U.S. patent application number 13/211832 was filed with the patent office on 2012-02-16 for use of apoptosis inhibiting compounds in degenerative neurological disorders. This patent application is currently assigned to NEUROLOGIX, INC.. Invention is credited to Michael Kaplitt, Serguei Moussatov.
Application Number | 20120039991 13/211832 |
Document ID | / |
Family ID | 36228268 |
Filed Date | 2012-02-16 |
United States Patent Application | 20120039991 |
Kind Code | A1 |
Kaplitt; Michael ; et al. | February 16, 2012 |
The invention provides methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain associated with a neurodegenerative diseases that is characterized by an excess buildup of buildup of intracellular protein aggregates. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding an inhibitor of apoptosis protein (IAP) to cells in the region.
Inventors: | Kaplitt; Michael; (New York, NY) ; Moussatov; Serguei; (New York, NY) |
Assignee: | NEUROLOGIX, INC. Fort Lee NJ |
Family ID: | 36228268 |
Appl. No.: | 13/211832 |
Filed: | August 17, 2011 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
11255637 | Oct 21, 2005 | 8017385 | ||
13211832 | ||||
60621307 | Oct 22, 2004 | |||
60686588 | Jun 2, 2005 | |||
Current U.S. Class: | 424/450 ; 514/17.7; 514/17.8; 514/44R |
Current CPC Class: | C12N 15/86 20130101; C12N 9/93 20130101; C12N 2830/48 20130101; C12N 2750/14111 20130101; C07K 14/4747 20130101; C07K 2319/02 20130101; C12N 2750/14143 20130101; C12N 2800/107 20130101; A61K 48/00 20130101; A61P 25/00 20180101; C12N 2830/15 20130101; A61P 25/16 20180101; A61P 25/28 20180101 |
Class at Publication: | 424/450 ; 514/44.R; 514/17.7; 514/17.8 |
International Class: | A61K 9/127 20060101 A61K009/127; A61P 25/16 20060101 A61P025/16; A61P 25/00 20060101 A61P025/00; A61P 25/28 20060101 A61P025/28; A61K 31/7088 20060101 A61K031/7088; A61K 38/16 20060101 A61K038/16 |
Sequence CWU 1
1
651497PRTHomo sapiens 1Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr
Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu
Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro
Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly
Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp
Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys
Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn
Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln
Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120
125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly
130 135 140Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro
Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln
Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala
Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln
Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys
Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro Asn Cys
Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230 235
240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu
245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe
Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu
Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val
Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys Pro
Ser Glu Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro
Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile
Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val
Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360
365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe
370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln
Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val
Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu
Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu
Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys Ile Cys
Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460Cys Gly His
Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys465 470 475
480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met
485 490 495Ser294PRTHomo sapiens 2Pro Arg Asn Pro Ser Met Ala Asp
Tyr Glu Ala Arg Ile Phe Thr Phe1 5 10 15Gly Thr Trp Ile Tyr Ser Val
Asn Lys Glu Gln Leu Ala Arg Ala Gly 20 25 30Phe Tyr Ala Leu Gly Glu
Gly Asp Lys Val Lys Cys Phe His Cys Gly 35 40 45Gly Gly Leu Thr Asp
Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 50 55 60Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln65 70 75 80Glu Tyr
Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu 85
903497PRTArtificial Sequencesynthetic construct 3Met Thr Phe Asn
Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys
Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala
Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg
Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55
60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65
70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly
Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile
Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg
Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp
Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr
Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala
Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu
Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly
Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200
205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe
210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg
Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro
Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr
Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val
Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly
Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu
Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315
320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln
325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu
Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg
Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu
Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile
Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys
Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys
Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys
Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440
445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro
450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val
Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys
Gln Lys Ile Phe Met 485 490 495Ser4497PRTArtificial
SequenceSynthetic construct 4Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys
Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys
Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460Cys
Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys465 470
475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe
Met 485 490 495Ser5497PRTArtificial SequenceSynthetic construct
5Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5
10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys
Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr
Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val
Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly
Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys
Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser
Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn
Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser
Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val
Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155
160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr
165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr
Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly
Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser
Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly
Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser
Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn
Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly
Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280
285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly
290 295 300Gly Gly Leu Thr Asp Ala Lys Pro Ser Glu Asp Pro Trp Glu
Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu
Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr
His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr
Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn
Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys
Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395
400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn
405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser
Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu
Gln Glu Glu Lys 435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile
Ala Ile Val Phe Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys
Gln Cys Ala Glu Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr
Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490
495Ser6497PRTArtificial SequenceSynthetic construct 6Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Trp Lys Pro Ser Ser Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr
Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375
380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile
Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala
Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser
Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln
Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys Ile Cys Met
Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460Cys Gly His Leu
Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys465 470 475 480Cys
Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490
495Ser7497PRTArtificial SequenceSynthetic construct 7Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe
Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu
Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr
Phe Lys Gln Lys Ile Phe Met 485 490 495Ser8449PRTArtificial
SequenceSynthetic construct 8Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys
Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440
445Leu9497PRTArtificial SequenceSynthetic construct 9Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe
Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu
Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr
Phe Lys Gln Lys Ile Phe Met 485 490 495Ser10497PRTArtificial
SequenceSynthetic construct 10Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Ala Lys
Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys
Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460Cys
Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys465 470
475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe
Met 485 490 495Ser11497PRTArtificial SequenceSynthetic construct
11Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1
5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys
Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr
Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val
Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly
Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys
Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser
Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn
Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser
Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val
Ala Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155
160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr
165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr
Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly
Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser
Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly
Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser
Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn
Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly
Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280
285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly
290 295 300Gly Gly Leu Thr Asp Trp Lys Pro Ser Ser Asp Pro Trp Glu
Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu
Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr
His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr
Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn
Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370
375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile
Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala
Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser
Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln
Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys Ile Cys Met
Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460Cys Gly His Leu
Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys465 470 475 480Cys
Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490
495Ser12497PRTArtificial SequenceSynthetic construct 12Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe
Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu
Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr
Phe Lys Gln Lys Ile Phe Met 485 490 495Ser13449PRTArtificial
SequenceSynthetic construct 13Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys
Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440
445Leu14497PRTArtificial SequenceSynthetic construct 14Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Ala Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe
Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu
Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr
Phe Lys Gln Lys Ile Phe Met 485 490 495Ser15497PRTArtificial
SequenceSynthetic construct 15Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys
Pro Ser Ser Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys
Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460Cys
Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys465 470
475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe
Met 485 490 495Ser16497PRTArtificial SequenceSynthetic construct
16Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1
5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys
Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr
Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val
Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly
Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys
Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser
Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn
Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser
Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val
Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155
160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr
165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr
Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly
Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser
Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly
Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser
Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn
Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly
Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280
285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly
290 295 300Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu
Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu
Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr
His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr
Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn
Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys
Asp Ile Lys Lys Ile Met Glu
Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu
Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser
Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile
Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu
Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455
460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp
Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln
Lys Ile Phe Met 485 490 495Ser17449PRTArtificial SequenceSynthetic
construct 17Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro
Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg
Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala
Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp
Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln
Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro
Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr
Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val
Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg
Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln
Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150
155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp
Tyr 165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu
Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys
Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp
Ser Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu
Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val
Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg
Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265
270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His
Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro
Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr
Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile His
Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu
Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe
Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser
Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390
395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val
Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr
Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg
Leu Gln Glu Glu Lys 435 440 445Leu 18497PRTArtificial
SequenceSynthetic construct 18Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Ala Lys
Pro Ser Ser Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys
Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460Cys
Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys465 470
475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe
Met 485 490 495Ser19497PRTArtificial SequenceSynthetic construct
19Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1
5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys
Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr
Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val
Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly
Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys
Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser
Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn
Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser
Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val
Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155
160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr
165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr
Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly
Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser
Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly
Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser
Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn
Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly
Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280
285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly
290 295 300Gly Gly Leu Thr Asp Ala Lys Pro Ser Glu Asp Pro Trp Glu
Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu
Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr
His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr
Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn
Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys
Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395
400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn
405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser
Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu
Gln Glu Glu Lys 435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile
Ala Ile Val Phe Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys
Gln Cys Ala Glu Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr
Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490
495Ser20449PRTArtificial SequenceSynthetic construct 20Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Ala Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu21497PRTArtificial SequenceSynthetic construct 21Met
Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10
15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr
20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu
Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg
Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp
Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg
Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr
Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr
Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu
Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp
Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr
Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170
175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr
180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys
Leu Lys 195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His
Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn
Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp
Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser
Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp
Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe
Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295
300Gly Gly Leu Thr Asp Trp Lys Pro Ser Ser Asp Pro Trp Glu Gln
His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu
Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His
Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro
Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro
Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp
Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly
Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410
415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln
420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu
Glu Lys 435 440
445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro
450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val
Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys
Gln Lys Ile Phe Met 485 490 495Ser22449PRTArtificial
SequenceSynthetic construct 22Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys
Pro Ser Ser Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu
23449PRTArtificial SequenceSynthetic construct 23Met Thr Phe Asn
Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys
Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala
Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg
Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55
60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65
70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly
Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile
Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg
Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp
Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp Ile Ser Asp Thr
Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala
Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu
Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly
Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200
205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe
210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg
Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro
Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr
Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val
Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly
Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu
Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315
320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln
325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu Glu
Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg
Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu
Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile
Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys
Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys
Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys
Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440
445Leu 24497PRTArtificial SequenceSynthetic construct 24Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Ala Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe
Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu
Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr
Phe Lys Gln Lys Ile Phe Met 485 490 495Ser25497PRTArtificial
SequenceSynthetic construct 25Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys
Pro Ser Ser Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys
Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460Cys
Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys465 470
475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe
Met 485 490 495Ser26497PRTArtificial SequenceSynthetic construct
26Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1
5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys
Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr
Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val
Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly
Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys
Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser
Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn
Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser
Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val
Ala Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155
160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr
165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr
Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly
Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser
Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly
Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser
Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn
Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly
Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280
285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly
290 295 300Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu
Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu
Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr
His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr
Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn
Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys
Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395
400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn
405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser
Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu
Gln Glu Glu Lys 435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile
Ala Ile Val Phe Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys
Gln Cys Ala Glu Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr
Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490
495Ser27449PRTArtificial SequenceSynthetic construct 27Met Thr Phe
Asn
Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys
Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala
Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg
Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55
60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65
70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly
Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile
Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg
Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp
Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr
Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala
Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu
Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly
Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200
205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg His Phe
210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg
Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro
Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr
Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val
Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly
Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu
Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315
320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln
325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu
Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg
Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu
Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile
Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys
Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys
Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys
Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440
445Leu 28497PRTArtificial SequenceSynthetic construct 28Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe
Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu
Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr
Phe Lys Gln Lys Ile Phe Met 485 490 495Ser29497PRTArtificial
SequenceSynthetic construct 29Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Ala Lys
Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys
Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460Cys
Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys465 470
475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe
Met 485 490 495Ser30449PRTArtificial SequenceSynthetic construct
30Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1
5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys
Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr
Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val
Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly
Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys
Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser
Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn
Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser
Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val
Ala Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155
160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr
165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr
Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly
Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser
Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly
Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser
Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn
Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly
Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280
285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly
290 295 300Gly Gly Leu Thr Asp Ala Lys Pro Ser Glu Asp Pro Trp Glu
Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu
Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr
His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr
Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn
Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys
Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395
400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn
405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser
Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu
Gln Glu Glu Lys 435 440 445Leu31497PRTArtificial SequenceSynthetic
construct 31Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro
Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg
Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala
Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp
Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln
Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro
Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr
Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val
Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg
Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln
Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150
155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp
Tyr 165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu
Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys
Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp
Ser Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu
Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val
Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg
Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265
270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His
Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys Pro Ser Ser Asp Pro
Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr
Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala
Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu
Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe
Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser
Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390
395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val
Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr
Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg
Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn
Ile Ala Ile Val Phe Val Pro 450 455 460Cys Gly His Leu Val Thr Cys
Lys Gln Cys Ala Glu Ala Val Asp Lys465 470 475 480Cys Pro Met Cys
Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490
495Ser32449PRTArtificial SequenceSynthetic construct 32Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55
60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65
70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly
Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile
Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg
Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp
Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr
Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala
Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu
Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly
Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200
205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe
210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg
Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro
Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr
Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val
Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly
Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu
Thr Asp Trp Lys Pro Ser Ser Asp Pro Trp Glu Gln His305 310 315
320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln
325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu
Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg
Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu
Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile
Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys
Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys
Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys
Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440
445Leu33449PRTArtificial SequenceSynthetic construct 33Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu 34497PRTArtificial SequenceSynthetic construct 34Met
Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10
15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr
20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu
Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg
Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp
Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg
Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr
Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr
Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu
Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp
Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr
Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170
175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr
180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys
Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser Glu His
Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn
Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp
Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser
Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp
Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe
Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295
300Gly Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro Trp Glu Gln
His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu
Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His
Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro
Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro
Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp
Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly
Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410
415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln
420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu
Glu Lys 435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile
Val Phe Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys
Ala Glu Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val
Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490
495Ser35497PRTArtificial SequenceSynthetic construct 35Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Ala Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe
Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu
Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr
Phe Lys Gln Lys Ile Phe Met 485 490 495Ser36449PRTArtificial
SequenceSynthetic construct 36Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Ala Lys
Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu
37449PRTArtificial SequenceSynthetic construct 37Met Thr Phe Asn
Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys
Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala
Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg
Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55
60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65
70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly
Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile
Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg
Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp
Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp Ile Ser Asp Thr
Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala
Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr
165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr
Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly
Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser
Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly
Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser
Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn
Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly
Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280
285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly
290 295 300Gly Gly Leu Thr Asp Trp Lys Pro Ser Ser Asp Pro Trp Glu
Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu
Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr
His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr
Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn
Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys
Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395
400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn
405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser
Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu
Gln Glu Glu Lys 435 440 445Leu 38449PRTArtificial SequenceSynthetic
construct 38Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro
Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg
Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala
Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp
Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln
Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro
Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr
Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val
Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg
Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln
Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150
155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp
Tyr 165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu
Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys
Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp
Ser Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu
Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val
Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg
Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265
270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His
Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro
Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr
Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala
Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu
Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe
Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser
Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390
395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val
Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr
Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg
Leu Gln Glu Glu Lys 435 440 445Leu 39497PRTArtificial
SequenceSynthetic construct 39Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys
Pro Ser Ser Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys
Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460Cys
Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys465 470
475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe
Met 485 490 495Ser40497PRTArtificial SequenceSynthetic construct
40Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1
5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys
Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr
Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val
Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly
Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys
Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser
Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn
Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser
Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val
Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155
160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr
165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr
Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly
Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser
Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly
Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser
Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn
Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly
Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280
285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly
290 295 300Gly Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro Trp Glu
Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu
Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr
His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr
Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn
Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys
Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395
400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn
405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser
Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu
Gln Glu Glu Lys 435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile
Ala Ile Val Phe Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys
Gln Cys Ala Glu Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr
Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490
495Ser41449PRTArtificial SequenceSynthetic construct 41Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu42449PRTArtificial SequenceSynthetic construct 42Met
Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10
15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr
20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu
Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg
Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp
Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg
Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr
Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr
Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu
Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp
Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr
Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170
175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr
180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys
Leu Lys 195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His
Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn
Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp
Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser
Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp
Ile Tyr Ser Val Asn Lys Glu Gln Leu
Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val
Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Ala Lys Pro
Ser Glu Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro
Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile
Asn Asn Ile Ala Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val
Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360
365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe
370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln
Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val
Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu
Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu
Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu
43449PRTArtificial SequenceSynthetic construct 43Met Thr Phe Asn
Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys
Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala
Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg
Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55
60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65
70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly
Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile
Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg
Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp
Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp Ile Ser Asp Thr
Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala
Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu
Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly
Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200
205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe
210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg
Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro
Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr
Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val
Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly
Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu
Thr Asp Trp Lys Pro Ser Ser Asp Pro Trp Glu Gln His305 310 315
320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln
325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu Glu
Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg
Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu
Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile
Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys
Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys
Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys
Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440
445Leu 44497PRTArtificial SequenceSynthetic construct 44Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe
Val Pro 450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu
Ala Val Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr
Phe Lys Gln Lys Ile Phe Met 485 490 495Ser45497PRTArtificial
SequenceSynthetic construct 45Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Ala Lys
Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys
Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460Cys
Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys465 470
475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe
Met 485 490 495Ser46449PRTArtificial SequenceSynthetic construct
46Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1
5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys
Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr
Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val
Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly
Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys
Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser
Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn
Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser
Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val
Ala Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155
160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr
165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr
Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly
Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser
Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly
Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser
Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn
Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly
Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280
285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly
290 295 300Gly Gly Leu Thr Asp Ala Lys Pro Ser Glu Asp Pro Trp Glu
Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu
Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr
His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr
Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn
Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys
Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395
400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn
405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser
Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu
Gln Glu Glu Lys 435 440 445Leu 47497PRTArtificial SequenceSynthetic
construct 47Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro
Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg
Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala
Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp
Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln
Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro
Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr
Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val
Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg
Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln
Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150
155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp
Tyr 165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu
Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys
Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp
Ser Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu
Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val
Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg
Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265
270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His
Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys Pro Ser Ser Asp Pro
Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr
Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala
Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu
Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe
Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser
Phe Lys Asp Ile Lys Lys Ile Met Glu
Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu
Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser
Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile
Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu
Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455
460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp
Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln
Lys Ile Phe Met 485 490 495Ser48449PRTArtificial SequenceSynthetic
construct 48Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro
Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg
Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala
Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp
Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln
Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro
Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr
Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val
Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg
Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln
Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150
155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp
Tyr 165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu
Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys
Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp
Ser Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu
Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val
Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg
Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265
270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His
Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys Pro Ser Ser Asp Pro
Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr
Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile His
Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu
Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe
Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser
Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390
395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val
Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr
Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg
Leu Gln Glu Glu Lys 435 440 445Leu 49449PRTArtificial
SequenceSynthetic construct 49Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys
Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu
50497PRTArtificial SequenceSynthetic construct 50Met Thr Phe Asn
Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys
Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala
Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg
Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55
60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65
70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly
Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile
Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg
Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp
Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr
Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala
Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu
Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly
Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200
205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe
210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg
Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro
Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr
Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val
Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly
Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu
Thr Asp Ala Lys Pro Ser Ser Asp Pro Trp Glu Gln His305 310 315
320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln
325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu Glu
Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg
Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu
Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile
Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys
Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys
Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys
Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440
445Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro
450 455 460Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val
Asp Lys465 470 475 480Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys
Gln Lys Ile Phe Met 485 490 495Ser51449PRTArtificial
SequenceSynthetic construct 51Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Ala Lys
Pro Ser Ser Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met
Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys
Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val
Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys Asp Ser Met Pro
Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445Leu
52449PRTArtificial SequenceSynthetic construct 52Met Thr Phe Asn
Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys
Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala
Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg
Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55
60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65
70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly
Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile
Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg
Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp
Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr
Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala
Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu
Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly
Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200
205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe
210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg
Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro
Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr
Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val
Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly
Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu
Thr Asp Ala Lys Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315
320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln
325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu Glu
Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg
Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln Glu
Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys Ile
Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr Lys
Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln Lys
Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430Lys
Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440
445Leu 53449PRTArtificial SequenceSynthetic construct 53Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala
35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys
Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser
Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe
Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn
Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu
Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr
His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala Ile
Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys
Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170
175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr
180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys
Leu Lys 195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His
Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn
Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp
Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser
Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp
Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe
Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295
300Gly Gly Leu Thr Asp Trp Lys Pro Ser Ser Asp Pro Trp Glu Gln
His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu
Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His
Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro
Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro
Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp
Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly
Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410
415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln
420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu
Glu Lys 435 440 445Leu 54497PRTArtificial SequenceSynthetic
construct 54Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro
Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg
Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala
Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp
Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln
Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro
Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr
Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val
Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg
Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln
Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150
155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp
Tyr 165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu
Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys
Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp
Ser Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu
Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val
Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg
Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265
270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His
Cys Gly 290 295 300Gly Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro
Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr
Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala
Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu
Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe
Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser
Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390
395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val
Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr
Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg
Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn
Ile Ala Ile Val Phe Val Pro 450 455 460Cys Gly His Leu Val Thr Cys
Lys Gln Cys Ala Glu Ala Val Asp Lys465 470 475 480Cys Pro Met Cys
Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490
495Ser55449PRTArtificial SequenceSynthetic construct 55Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu 56449PRTArtificial SequenceSynthetic construct 56Met
Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10
15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr
20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu
Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg
Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp
Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg
Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr
Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr
Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu
Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp
Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr
Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170
175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr
180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys
Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser Glu His
Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn
Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp
Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser
Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp
Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe
Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295
300Gly Gly Leu Thr Asp Ala Lys Pro Ser Glu Asp Pro Trp Glu Gln
His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu
Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His
Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro
Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro
Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp
Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly
Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410
415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln
420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu
Glu Lys 435 440 445Leu 57449PRTArtificial SequenceSynthetic
construct 57Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro
Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg
Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala
Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp
Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln
Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro
Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr
Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val
Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg
Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln
Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150
155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp
Tyr 165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu
Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys
Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp
Ser Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu
Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val
Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg
Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265
270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His
Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys Pro Ser Ser Asp Pro
Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr
Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala
Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu
Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe
Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser
Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390
395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val
Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr
Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg
Leu Gln Glu Glu Lys 435 440 445Leu 58449PRTArtificial
SequenceSynthetic construct 58Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys
Leu Lys 195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His
Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn
Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp
Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser
Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp
Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe
Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295
300Gly Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro Trp Glu Gln
His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu
Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His
Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro
Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro
Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp
Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly
Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410
415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln
420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu
Glu Lys 435 440 445Leu 59497PRTArtificial SequenceSynthetic
construct 59Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro
Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg
Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala
Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp
Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln
Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro
Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr
Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val
Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg
Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln
Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150
155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp
Tyr 165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu
Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys
Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp
Ser Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu
Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val
Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg
Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265
270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His
Cys Gly 290 295 300Gly Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro
Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr
Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala
Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu
Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe
Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser
Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390
395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val
Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr
Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg
Leu Gln Glu Glu Lys 435 440 445Leu Cys Lys Ile Cys Met Asp Arg Asn
Ile Ala Ile Val Phe Val Pro 450 455 460Cys Gly His Leu Val Thr Cys
Lys Gln Cys Ala Glu Ala Val Asp Lys465 470 475 480Cys Pro Met Cys
Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490
495Ser60449PRTArtificial SequenceSynthetic construct 60Met Thr Phe
Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn
Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe
Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40
45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala
Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile
Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser
Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly
Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu Thr His
Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Asp Ile Ser
Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr Cys Glu
Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala
His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185
190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg
His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn
Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp Arg Asn
Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser Met Ala
Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr
Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala
Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300Gly
Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro Trp Glu Gln His305 310
315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly
Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu
Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu 61449PRTArtificial SequenceSynthetic construct 61Met
Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10
15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr
20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu
Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg
Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp
Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg
Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr
Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr
Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu
Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala
Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr
Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170
175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr
180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys
Leu Lys 195 200 205Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His
Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn
Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp
Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser
Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp
Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe
Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295
300Gly Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro Trp Glu Gln
His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu
Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala Leu Thr His
Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro
Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro
Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp
Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly
Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410
415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln
420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu
Glu Lys 435 440 445Leu 62449PRTArtificial SequenceSynthetic
construct 62Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro
Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg
Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala
Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp
Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln
Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro
Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr
Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val
Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg
Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln
Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150
155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp
Tyr 165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu
Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys
Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp
Ser Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu
Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val
Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg
Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265
270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His
Cys Gly 290 295 300Gly Gly Leu Thr Asp Trp Lys Pro Ser Ser Asp Pro
Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr
Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala
Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu
Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe
Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser
Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390
395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val
Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr
Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg
Leu Gln Glu Glu Lys 435 440 445Leu 63449PRTArtificial
SequenceSynthetic construct 63Met Thr Phe Asn Ser Phe Glu Gly Ser
Lys Thr Cys Val Pro Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly
Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr
Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala
Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His
Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu
Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105
110Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
115 120 125Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg
Thr Gly 130 135 140Gln Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg
Asn Pro Ala Met145 150 155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser
Phe Gln Asn Trp Pro Asp Tyr 165 170 175Ala His Leu Thr Pro Arg Glu
Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln
Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu
Pro Cys Ser Arg Ala Trp Ser Glu His Arg Arg His Phe 210 215 220Pro
Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230
235 240Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn
Leu 245 250 255Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile
Phe Thr Phe 260 265 270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln
Leu Ala Arg Ala Gly 275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys
Val Lys Cys Phe His Cys Gly 290 295 300Gly Gly Leu Thr Asp Ala Lys
Pro Ser Glu Asp Pro Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr
Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr
Ile Asn Asn Ile Ala Leu Thr His Ser Leu Glu Glu Cys Leu 340 345
350Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr
Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro Met Val Gln
Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp Ile Lys Lys
Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly Ser Asn Tyr
Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415Ala Gln
Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425
430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
435 440 445Leu 64449PRTArtificial SequenceSynthetic construct 64Met
Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp1 5 10
15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr
20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu
Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg
Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp
Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg
Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr
Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val Glu Asn Tyr
Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg Pro Ser Glu
Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln Val Val Ala
Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150 155 160Tyr
Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170
175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr
180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys
Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp Ser Glu His
Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu Gly Arg Asn
Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val Ser Ser Asp
Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg Asn Pro Ser
Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265 270Gly Thr Trp
Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285Phe
Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295
300Gly Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro Trp Glu Gln
His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu
Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile His Leu Thr His
Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu Lys Thr Pro
Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe Gln Asn Pro
Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser Phe Lys Asp
Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390 395 400Gly
Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 405 410
415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr Ser Leu Gln
420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu
Glu Lys 435 440 445Leu 65449PRTArtificial SequenceSynthetic
construct 65Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro
Ala Asp1 5 10 15Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg
Leu Lys Thr 20 25 30Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala
Ser Thr Leu Ala 35 40 45Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp
Thr Val Arg Cys Phe 50 55 60Ser Cys His Ala Ala Val Asp Arg Trp Gln
Tyr Gly Asp Ser Ala Val65 70 75 80Gly Arg His Arg Lys Val Ser Pro
Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95Tyr Leu Glu Asn Ser Ala Thr
Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110Gly Gln Tyr Lys Val
Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125Leu Asp Arg
Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140Gln
Val Val Ala Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met145 150
155 160Tyr Cys Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp
Tyr 165 170 175Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu
Tyr Tyr Thr 180 185 190Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys
Gly Gly Lys Leu Lys 195 200 205Asn Trp Glu Pro Cys Ser Arg Ala Trp
Ser Glu His Arg Arg His Phe 210 215 220Pro Asn Cys Phe Phe Val Leu
Gly Arg Asn Leu Asn Ile Arg Ser Glu225 230 235 240Ser Asp Ala Val
Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255Pro Arg
Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265
270Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
275 280 285Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His
Cys Gly 290 295 300Gly Gly Leu Thr Asp Ala Lys Pro Ser Ser Asp Pro
Trp Glu Gln His305 310 315 320Ala Lys Trp Tyr Pro Gly Cys Lys Tyr
Leu Leu Glu Gln Lys Gly Gln 325 330 335Glu Tyr Ile Asn Asn Ile Ala
Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350Val Arg Thr Thr Glu
Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365Thr Ile Phe
Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380Ser
Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser385 390
395 400Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val
Asn 405 410 415Ala Gln Lys Asp Ser Met Pro Asp Glu Ser Ser Gln Thr
Ser Leu Gln 420 425 430Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg
Leu Gln Glu Glu Lys 435 440 445Leu
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