U.S. patent application number 13/199543 was filed with the patent office on 2011-12-29 for trehalose-containing topical drying composition and method of using same.
Invention is credited to Frank P. Marchese, Harold J. Mermelstein, Xinghua Pan.
Application Number | 20110318291 13/199543 |
Document ID | / |
Family ID | 41431540 |
Filed Date | 2011-12-29 |
United States Patent
Application |
20110318291 |
Kind Code |
A1 |
Marchese; Frank P. ; et
al. |
December 29, 2011 |
Trehalose-containing topical drying composition and method of using
same
Abstract
A topical drying composition is providing containing trehalose
as the effective moisture (sweat) removing ingredient. The
composition may be used in aqueous form or preferably as a cream
and in addition to trehalose it contains several ingredients such
as sorbitan monolaurate, polysorbitan, a moisturizer, a thickener,
a softener, an antibacterial agent and a pH adjusting component to
adjust the pH of the composition between about 5.5 to about 7.5.
Sterilized water is used as the carrier for the composition. The
topical composition can be applied to the area which is vulnerable
to sweating after vigorous exercise in order to moisturize sweating
on the skin.
Inventors: |
Marchese; Frank P.;
(Bronxville, NY) ; Pan; Xinghua; (Hamden, CT)
; Mermelstein; Harold J.; (Bronx, NY) |
Family ID: |
41431540 |
Appl. No.: |
13/199543 |
Filed: |
September 2, 2011 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
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12214863 |
Jun 24, 2008 |
|
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13199543 |
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Current U.S.
Class: |
424/65 |
Current CPC
Class: |
A61K 31/7016 20130101;
A61K 8/60 20130101; A61Q 15/00 20130101 |
Class at
Publication: |
424/65 |
International
Class: |
A61K 8/60 20060101
A61K008/60; A61Q 15/00 20060101 A61Q015/00 |
Claims
1. A topical drying composition comprising trehalose as the
effective skin drying ingredient, in an aqueous buffer
solution.
2. The composition of claim 1, comprising trehalose in an amount
effective for removal of sweat or moisture from skin.
3. The composition of claim 1, wherein the composition comprises a
buffer to control the pH of the composition.
4. The composition of claim 3, wherein the pH of the composition is
between about 5.5 and about 7.0.
5. A method of removing topical moisture produced on the skin of a
person resulting from perspiration comprising applying to a desired
area of the skin of the person a topical drying composition
comprising trehalose as the effective skin drying ingredient, in an
aqueous buffer solution.
6. The method of claim 5, wherein the composition comprises
trehalose in an amount effective for removal of sweat or moisture
from skin.
7. The method of claim 5, wherein the composition comprises a
buffer to control the pH of the composition.
8. The method of claim 7, wherein the pH of the composition is
between about 5.5 and about 7.0.
9. The method of claim 5, wherein the perspiration is due to
exercise.
10. The method of claim 5, wherein the perspiration is associated
with playing tennis.
11. The method of claim 5, wherein the perspiration is associated
with golfing.
12. The method of claim 5, wherein the perspiration is associated
with aerobics.
13. The method of claim 5, wherein the perspiration is associated
with strenuous sweat-producing activity.
14. The method of claim 5, wherein the topical drying composition
is applied to an area of skin of the person that is vulnerable to
sweating.
15. The method of claim 5, wherein the topical drying composition
is applied to the hands of the person.
16. A method of removing topical moisture produced on the hands of
a person resulting from perspiration comprising applying to the
hands of the person a topical drying composition comprising
trehalose as the effective skin drying ingredient.
17. The method of claim 16, wherein the topical drying composition
is in the form of an aqueous buffer solution.
18. The method of claim 16, wherein the topical drying composition
is in the form of a cream.
19. The method of claim 16, wherein the perspiration is due to
exercise.
20. The method of claim 16, wherein the perspiration is associated
with playing tennis, golfing, aerobics or other strenuous
sweat-producing activity.
Description
RELATED APPLICATIONS
[0001] This application is a continuation of co-pending application
Ser. No. 12/214,863 filed Jun. 24, 2008.
FIELD OF THE INVENTION
[0002] The present invention relates generally to topical drying
composition and is particularly related to topical drying
composition containing effective amount of trehalose as the drying
ingredient. In its more specific aspect, this invention relates to
a topical drying composition containing an effective amount of
trehalose which enhances drying the skin when it is topically
applied to the skin of persons, such as athletes, after
perspiration due to exercise, such as playing tennis, golf,
aerobics or after other strenuous sweat-producing activities.
BACKGROUND OF THE INVENTION
[0003] Trehalose is a known non-reducing disaccharide composed of
D.sub.+glucose units. It is a white, odorless, sweet-tasting powder
and, like maltose, is about 45% as sweet as sugar and has a very
low hydroscopicity (moisture attraction). Trehalose is found in
honey, bread, beer and seafood and there are several prior art
patents relating to various uses of trehalose. For example, U.S.
Pat. No. 4,839,164 discloses cosmetic compositions containing
trehalose which increase the penetration of certain therapeutically
beneficial ingredients into the skin thereby enhancing the
therapeutic effects of those ingredients on the skin. The trehalose
is used in a pharmaceutically acceptable carrier and several
trehalose-containing formulations are disclosed in said patent,
such as shampoo formulations, hair-conditioning formulations, skin
care gel formulations, lotions, and skin care creams.
[0004] U.S. Pat. No. 5,543,513 discloses the use of anhydrous
trehalose as a desiccant for dehydrating various products such as
dehydrated food as well as dehydrated pharmaceuticals. High-quality
food products having reduced moisture content can be prepared by
incorporating anhydrous trehalose into food products having
relatively high moisture content thereby converting the anhydrous
trehalose into hydrous crystalline trehalose.
[0005] U.S. Pat. No. 6,555,526 discloses an ophthalmic
pharmaceutical composition comprising trehalose as the effective
ingredient. As disclosed in said patent, there are three types of
optical isomers of trehalose, i.e., .varies.,.varies.-trehalose,
.varies.,.beta.-trehalose and .beta.,.beta.-trehalose. All isomers
exert therapeutic and/or prophylactic effect on signs of Sjorgen
syndrome.
[0006] U.S. Pat. No. 6,723,170 discloses a crystalline trehalose
dihydrate with low hydroscopicity. Variety of uses are disclosed
for the crystalline trehalose dihydrate, including its use as a
sweetener, taste-improving agent, in feeds and pet foods for
animals, in soaps, skin creams, body shampoos, hair creams,
moisture-controlling agent and a host of other uses disclosed in
said patent.
[0007] Notwithstanding a variety of uses of trehalose disclosed in
the prior art patents, none, so far is known, recognize the
efficacy of trehalose for use in a topical drying composition.
[0008] Therefore, it is an object of the present invention to use
trehalose in a topical drying composition.
[0009] It is a further object of the present invention to provide a
topical drying composition containing trehalose as the effective
ingredient for sweat removal.
[0010] It is also an object of this invention to provide a topical
drying composition containing effective amount of trehalose and a
suitable carrier:
[0011] It is another object of this invention to provide a method
of drying the skin by the topical application of
trehalose-containing composition in which trehalose is the
effective skin drying ingredient.
[0012] The foregoing and other objects and features of the present
invention will be more clearly understood from the ensuing
description and illustrative examples.
SUMMARY OF THE INVENTION
[0013] This invention provides a topical drying composition
containing an effective amount of trehalose, in hydrous and/or
anhydrous form, in an acceptable carrier such as sterilized water.
The composition further includes sorbitan monolaurate, polysorbitan
and a pH adjuster in an amount to adjust the pH of the composition
between about 5.5 to about 7.5. The pH adjusting ingredient may be
sodium chloride, potassium chloride, sodium hydrogen phosphate and
borax, or a mixtures thereof.
[0014] The composition of this invention may be prepared in cream
form and thus may include a thickener such as carbomer Ultrex 10,
EDTA softener, moisturizer such as dimethicone 200, cocoa butter to
impart smoothness to the cream, and antibacterial agent such as
sodium benzoate and potassium benzoate.
[0015] The composition; whether in aqueous solution form or as a
cream, is applied to the skin in the areas which are vulnerable to
perspiration after vigorous exercise. When tested by several
volunteers, they responded with virtually no perspiration after
several hours of vigorous exercise in a gym on a bicycle or
treadmill, or even after several miles of jogging when normally the
subjects experienced perspiration in the past when they did not
apply the composition.
DETAILED DESCRIPTION OF THE INVENTION
[0016] The topical drying compositions of this invention are
provided as aqueous solutions or preferably as creams with
desirable consistency. The trehalose ingredient in these
compositions may be the hydrous form, anhydrous form or mixture of
the hydrous and anhydrous trehalose, and the composition may
include a "buffer" as hereinafter described in order to control the
pH at a desired level. An antibacterial agent may also be included
in or due to impart antibacterial property to the composition.
[0017] The following illustrative examples describe the preparation
of various trehalose-containing compositions containing various
other necessary and/or desired ingredients in addition to the
essential ingredients. All parts are expressed by weight and weight
percent.
Example 1
[0018] 204 grams of distilled water was charged to a reaction
vessel equipped with a stirrer, at room temperature and ambient
pressure. Thereafter, 2.5 grams of a thickener, (Ultrex 10),
polyacrylic acid thickener available from B.F. Goodrich, Co. was
added slowly and mixed with the water in the vessel, followed by
addition of 1.5 grams of ethylene dramine tetra acetic acid (EDTA),
with continuous agitation resulting in mixture A. The clear mixture
was then heated to 45.degree. C.
[0019] A separate mixture (Mixture B) was prepared containing 40
grams sorbitan monolaurate (Arlacel 20 available from Ruger
Chemical Co., Inc.) 85 grams of polysorbate (Tween 20 available
from Ruger Chemical Co., Inc.) 23 grams of cocoa butter, 10 grams
of dimethicone 200 (polydimethylsiloxane) available from Dow
Corning, a moisturizer having a viscosity of 700 cps, 3 grams of 1%
of sodium benzoate and 1.5 grams of 1% potassium sorbate
(antibacterial agent), and the resulting mixture was heated to
60.degree. C. with constant stirring. Mixture B was then slowly
added to the vessel containing mixture A resulting in the formation
of homogeneous cream. The resulting cream was allowed to cool to
35.degree. C., followed by the addition of aqueous solution of 40
grams of hydrous trehalose in 100 grams of sterilized water and
mixed for 2 hours. The following table lists the ingredients of the
resulting cream.
TABLE-US-00001 TABLE 1 Ingredient Parts by Wt. Wt. % Sterilized
water 204.0 68.74 Carbopol Ultrex 10 .sup.(1) 2.5 0.06 EDTA
tetrasodium 1.5 0.04 Sorbitan monolaurate 40 10.3 Cocoa butter 23.0
5.1 Polysorbitan (Tween 20) 8.5 2.18 Dimethicone 200 10.0 2.57
Sodium benzoate 1% 3.0 0.77 Potassium sorbate 1% 1.5 0.04 Hydrous
Trehalose 40.0 10.2 TOTAL 334 100.0 .sup.(1) carboxy
polymethylene
The pH of the resulting cream was adjusted to 6.5 with 5% solutions
of sodium hydroxide.
Clinical Test on Formula No. 1
[0020] Six male volunteers ages 24, 35, 37, 42, 43 and 50 applied
the cream preparation in Example 1 to the axilla of one arm only.
After exercising in a gym on a bicycle and a treadmill for (4)
hours, they all reported that the axilla to which the cream was
applied was completely dry but the axilla of the other arm to which
the cream was not applied was wet with moisture.
Example 2
[0021] Following a similar procedure as in Example 1, another cream
formulation was prepared having the ingredients listed in the
following table
TABLE-US-00002 TABLE 2 Ingredient Parts by Wt. Wt. % Sterilized
water 203.9 64.9 Carbopol Ultrex 10 2.5 0.7 EDTA 1.5 0.5 Sorbitan
monolaurate (Arlacel 20) 27.7 8.8 Cocoa butter 23.1 7.3 Polysorbate
20 (Tween 20) 8.3 2.6 Dimethicone 200 10.0 3.2 Hyamine 0.1 0
Hydrous Trehalose 38.0 12 TOTAL 315.10 100
The pH of the resulting cream was adjusted to 6.4 with 10% sodium
hydroxide solution
Clinical Test on Formula No. 2
[0022] Three female volunteers ages 49, 53 and 59 applied the cream
formulation obtained in Example 2 to both of their armpits. After
exercising vigorously on a treadmill for 2 hours, they reported
minimal wetness compared to their normal experience when they did
not use the cream.
Example 3
[0023] The formulations in the following table was made by the same
general procedure heretofore described and was tested for its
efficacy.
TABLE-US-00003 TABLE 3 Ingredient Parts by Wt. Wt. % Sterilized
water 203.9 69.69 Carbomer thickener (Ultra 10) 2.5 .85 Tetra
Sodium EDTA 1.5 .51 Sorbitan monolaurate 27.7 9.46 Shea butter 23.1
7.89 Polysorbate 20 (Tween 20) 8.3 2.83 Dimethicone 200 10.0 3.41
Hyamine 0.7 .24 Hydrous Trehalose 15.0 5.12 TOTAL 292.7 100
The pH of the resulting cream was adjusted to 6.4 with 5% sodium
hydroxide solution
Clinical Test on Formula No. 3
[0024] Six male volunteers ages 24, 35, 37, 42, 43 and 50 applied
the cream to the axilla of one arm only. After exercising
vigorously in a gym using a bicycle and treadmill for (4) hours
they reported very little sweating in the armpit to which they
applied the cream but the other arm sweated as normal.
[0025] The same 6 volunteers applied the cream formulation of
Example 3 but without including trehalose. All reported significant
sweating of the arm.
Example 4
[0026] In this example the formulation did not contain the
dimethicone moisturizer but contained larger amount of
trehalose.
TABLE-US-00004 TABLE 4 Ingredient Parts by Wt. Wt. % Sterilized
water 204.0 64.95 Carbopol Ultrex 10 2.5 0.80 Tetra Sodium EDTA 1.5
0.50 Sorbitan monolaurate 28.0 8.90 Cocoa butter 23.0 7.30
Polysorbate 20 (Tween 20) 8.5 2.70 Sodium Benzoate 1% 3.0 0.95
Potassium Sorbate 1% 1.5 0.50 Hydrous Trehalose 42.0 13.40 TOTAL
314 100
The pH of the resulting cream was adjusted to 6.4 with 5% sodium
hydroxide solution
Clinical Test on Formula No. 4
[0027] Six male volunteers ages 21, 22, 27, 29, 30 and 34 applied
the cream to the axilla of both arms. After exercising vigorously
in a gym using a bicycle and a treadmill for 3.5 hours, all
volunteers reported negligible wetness in their armpits.
Example 5
Part A
[0028] 300 grams of distilled water was combined with 2.5 grams of
carbopol 934 and allowed to form a clear solution. Then 1.5 grams
of EDTA was added and the mixture was stirred until it dissolved.
This mixture was then heated to 55.degree. degrees centigrade with
stirring.
Part B
[0029] In a separate vessel 23 grams of cocoa butter was combined
with 28 grams of sorbitan monolaurate, 8.5 grams polysorbate 20,
and 10 grams of dimethicone. Then 0.4 grams of sodium chloride,
0.15 grams of potassium chloride, 0.15 of sodium hydrogen phosphate
and 0.1 of borax were added, and the entire mixture was then heated
to 60.degree. degrees centigrade.
Part C
[0030] Part B was then added slowly to Part A with vigorous
stirring forming Part C, a white cream.
Part D
[0031] 68.5 grams of trehalose, 3 grams of 1% sodium benzoate and
1.5 potassium sorbate were added to Part C and the mixed well for
several hours to form a cream having a pH of 7.0
[0032] Table 5 below lists the ingredients and the composition.
TABLE-US-00005 TABLE 5 Ingredient Parts by Wt. Wt. % Distilled
water 300.00 67.11 Carbopol 934 2.5 .56 Tetrasodium EDTA 1.5 .33
Cocoa Butter 23.0 5.14 Sorbitan monolaurate 28.0 6.26 Polysorbate
20 8.5 1.90 Dimethicone 200 10.0 2.23 Sodium Benzoate 1% 3.0 .67
Potassium Sorbate 1% 1.5 .33 Trehalose Anhydrous 68.5 15.30 Sodium
Chloride 0.4 0.09 Potassium Chloride 0.15 .03 Sodium hydrogen
phosphate 0.15 0.03 Borax 0.1 .02 TOTAL 447.3 100.00
The pH of the resulting cream was adjusted to 6.4 with 5% sodium
hydroxide solution
Clinical Test on Formula No. 5
[0033] The test was conducted on two male volunteers ages 55 and
67. Each volunteer applied the cream to his face, forehead and one
armpit and entered a sauna. After 1/2 hour they emerged from the
sauna and were examined. Their face and neck showed signs of
complete dryness and their armpits were completely dry. Their back
and legs were damp with perspiration.
[0034] The test was also conducted on three basketball players ages
18, 21 and 23 on an outside court at 82.degree. F. Each covered his
hands and forehead (without band) and armpits with the cream. After
playing for 1/2 hour, their hands and forehead were free of
moisture. After 2.5 hours their hands and forehead was still free
of moisture.
[0035] The test was also conducted on golfers ages 45, 56, 60 and,
64 on a very warm day 90.degree. F. Each covered both hands with
the cream. After eight holes of play their hands were dray and they
all claimed that the grip on the club improved with better control
and they did not even need to wear a glove.
[0036] The method of use of the composition simply involves
applying by hand a generous amount to the skin in the area
vulnerable to sweating, and spreading the composition to cover that
area. When using the composition in aqueous solution form, it may
be applied similarly, or from a container with an applicator or a
spray nozzle.
[0037] While the aforementioned compositions have been described
with certain degree of specificity, it is obvious to those skilled
in the art of formulating such compositions that several changes or
modification may be made which are nevertheless suggested from the
foregoing detailed description.
[0038] Optionally, other ingredients may be included in the cream
formulation described in the foregoing examples. For example, the
addition of a bovine collagen (1% aqueous solution of alphahydroxy
proline help restore the elasticity in the skin along with 1%
aqueous solution of elastin. Also, while the hydrous trehalose is
used as the effective ingredient, anhydrous trehalose may be used
instead, or in combination with hydrous trehalose. Also aqueous
buffer solutions of trehalose, hydrous and/or anhydrous have been,
found effective topical drying compositions.
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