U.S. patent application number 13/134056 was filed with the patent office on 2011-12-15 for methods for identifying analgesic agents. Invention is credited to Yigal P. Goldberg, Marcia L. MacDonald, Mark E. Samuels, Robin Sherrington.
Application Number | 20110306654 13/134056 |
Document ID | / |
Family ID | 38479374 |
Filed Date | 2011-12-15 |
United States Patent Application | 20110306654 |
Kind Code | A1 |
MacDonald; Marcia L. ; et al. | December 15, 2011 |
The present invention relates to the discovery that mutations in SCN9A are causative of Congenital Indifference to Pain (CIP) in humans. The invention also relates to methods of utilizing the SCN9A gene and expression products thereof for the screening and identification of therapeutic agents, including small organic compounds, which are selective for SCN9A, and are useful in the treatment of pain and other disorders. The invention also relates to methods of using these compounds to treat or otherwise ameliorate such disorders.
Inventors: | MacDonald; Marcia L.; (Vancouver, CA) ; Samuels; Mark E.; (Vancouver, CA) ; Sherrington; Robin; (West Vancouver, CA) ; Goldberg; Yigal P.; (Vancouver, CA) |
Family ID: | 38479374 |
Appl. No.: | 13/134056 |
Filed: | May 27, 2011 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
12590935 | Nov 17, 2009 | |||
13134056 | ||||
10369909 | Feb 19, 2003 | 7659082 | ||
12590935 | ||||
60357964 | Feb 19, 2002 | |||
60429836 | Nov 26, 2002 | |||
Current U.S. Class: | 514/44A ; 536/24.5 |
Current CPC Class: | C12Q 1/68 20130101; G01N 33/6893 20130101; C12Q 1/6827 20130101; A61P 29/00 20180101; C12Q 1/6813 20130101; C12Q 1/6809 20130101; A61P 25/00 20180101; A61P 25/04 20180101; C12Q 1/6806 20130101; A61P 25/08 20180101; C07H 21/04 20130101; C12Q 1/6897 20130101 |
Class at Publication: | 514/44.A ; 536/24.5 |
International Class: | A61K 31/7088 20060101 A61K031/7088; C07H 21/02 20060101 C07H021/02; A61P 25/08 20060101 A61P025/08; A61P 25/04 20060101 A61P025/04; A61P 25/00 20060101 A61P025/00; C07H 21/04 20060101 C07H021/04; A61P 29/00 20060101 A61P029/00 |
Sequence CWU 1
1
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tccgtttcaa tgccacacct 360gctttatata tgctttctcc tttcagtcct
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caaagaatgt 2700gtctgcaaga tcaatgatga ctgtacgctc ccacggtggc
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ggagagtgga tagagaccat gtgggactgt 2820atggaggtcg ctggtcaagc
tatgtgcctt attgtttaca tgatggtcat ggtcattgga 2880aacctggtgg
tcctaaacct atttctggcc ttattattga gctcatttag ttcagacaat
2940cttacagcaa ttgaagaaga ccctgatgca aacaacctcc agattgcagt
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3540aaaatctggt ggaacatcag gaaaacctgc tacaagattg ttgaacacag
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gagagcttta 3900agacctctaa gagccttatc tagatttgaa ggaatgaggg
tcgttgtgaa tgcactcata 3960ggagcaattc cttccatcat gaatgtgcta
cttgtgtgtc ttatattctg gctgatattc 4020agcatcatgg gagtaaattt
gtttgctggc aagttctatg agtgtattaa caccacagat 4080gggtcacggt
ttcctgcaag tcaagttcca aatcgttccg aatgttttgc ccttatgaat
4140gttagtcaaa atgtgcgatg gaaaaacctg aaagtgaact ttgataatgt
cggacttggt 4200tacctatctc tgcttcaagt tgcaactttt aagggatgga
cgattattat gtatgcagca 4260gtggattctg ttaatgtaga caagcagccc
aaatatgaat atagcctcta catgtatatt 4320tattttgtcg tctttatcat
ctttgggtca ttcttcactt tgaacttgtt cattggtgtc 4380atcatagata
atttcaacca acagaaaaag aagcttggag gtcaagacat ctttatgaca
4440gaagaacaga agaaatacta taatgcaatg aaaaagctgg ggtccaagaa
gccacaaaag 4500ccaattcctc gaccagggaa caaaatccaa ggatgtatat
ttgacctagt gacaaatcaa 4560gcctttgata ttagtatcat ggttcttatc
tgtctcaaca tggtaaccat gatggtagaa 4620aaggagggtc aaagtcaaca
tatgactgaa gttttatatt ggataaatgt ggtttttata 4680atccttttca
ctggagaatg tgtgctaaaa ctgatctccc tcagacacta ctacttcact
4740gtaggatgga atatttttga ttttgtggtt gtgattatct ccattgtagg
tatgtttcta 4800gctgatttga ttgaaacgta ttttgtgtcc cctaccctgt
tccgagtgat ccgtcttgcc 4860aggattggcc gaatcctacg tctagtcaaa
ggagcaaagg ggatccgcac gctgctcttt 4920gctttgatga tgtcccttcc
tgcgttgttt aacatcggcc tcctgctctt cctggtcatg 4980ttcatctacg
ccatctttgg aatgtccaac tttgcctatg ttaaaaagga agatggaatt
5040aatgacatgt tcaattttga gacctttggc aacagtatga tttgcctgtt
ccaaattaca 5100acctctgctg gctgggatgg attgctagca cctattctta
acagtaagcc acccgactgt 5160gacccaaaaa aagttcatcc tggaagttca
gttgaaggag actgtggtaa cccatctgtt 5220ggaatattct actttgttag
ttatatcatc atatccttcc tggttgtggt gaacatgtac 5280attgcagtca
tactggagaa ttttagtgtt gccactgaag aaagtactga acctctgagt
5340gaggatgact ttgagatgtt ctatgaggtt tgggagaagt ttgatcccga
tgcgacccag 5400tttatagagt tctctaaact ctctgatttt gcagctgccc
tggatcctcc tcttctcata 5460gcaaaaccca acaaagtcca gctcattgcc
atggatctgc ccatggttag tggtgaccgg 5520atccattgtc ttgacatctt
atttgctttt acaaagcgtg ttttgggtga gagtggggag 5580atggattctc
ttcgttcaca gatggaagaa aggttcatgt ctgcaaatcc ttccaaagtg
5640tcctatgaac ccatcacaac cacactaaaa cggaaacaag aggatgtgtc
tgctactgtc 5700attcagcgtg cttatagacg ttaccgctta aggcaaaatg
tcaaaaatat atcaagtata 5760tacataaaag atggagacag agatgatgat
ttactcaata aaaaagatat ggcttttgat 5820aatgttaatg agaactcaag
tccagaaaaa acagatgcca cttcatccac cacctctcca 5880ccttcatatg
atagtgtaac aaagccagac aaagagaaat atgaacaaga cagaacagaa
5940aaggaagaca aagggaaaga cagcaaggaa agcaaaaaat agagcttcat
ttttgatata 6000ttgtttacag cctgtgaaag tgatttattt gtgttaataa
aactcttttg aggaagtcta 6060tgccaaaatc ctttttatca aaatattctc
gaaggcagtg cagtcactaa ctctgatttc 6120ctaagaaagg tgggcagcat
tagcagatgg ttatttttgc actgatgatt ctttaagaat 6180cgtaagagaa
ctctgtagga attattgatt atagcataca aaagtgattc agttttttgg
6240tttttaataa atcagaagac catgtagaaa acttttacat ctgccttgtc
atcttttcac 6300aggattgtaa ttagtcttgt ttcccatgta aataaacaac
acacgcatac agaaaaaaaa 6360aaaaaaa 636721977PRTHomo sapiens 2Met Ala
Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr1 5 10 15Lys
Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 20 25
30Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys
35 40 45Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr
Gly 50 55 60Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu
Asp Pro65 70 75 80Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn
Lys Gly Lys Thr 85 90 95Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr
Met Leu Ser Pro Phe 100 105 110Ser Pro Leu Arg Arg Ile Ser Ile Lys
Ile Leu Val His Ser Leu Phe 115 120 125Ser Met Leu Ile Met Cys Thr
Ile Leu Thr Asn Cys Ile Phe Met Thr 130 135 140Met Asn Asn Pro Pro
Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr145 150 155 160Gly Ile
Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 165 170
175Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp
180 185 190Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn
Leu Gly 195 200 205Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg
Ala Leu Lys Thr 210 215 220Ile Ser Val Ile Pro Gly Leu Lys Thr Ile
Val Gly Ala Leu Ile Gln225 230 235 240Ser Val Lys Lys Leu Ser Asp
Val Met Ile Leu Thr Val Phe Cys Leu 245 250 255Ser Val Phe Ala Leu
Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 260 265 270His Lys Cys
Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 275 280 285Ile
Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 290 295
300Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr
Asp305 310 315 320Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys
Ile Gly Arg Asn 325 330 335Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr
Phe Ser Trp Ala Phe Leu 340 345 350Ala Leu Phe Arg Leu Met Thr Gln
Asp Tyr Trp Glu Asn Leu Tyr Gln 355 360 365Gln Thr Leu Arg Ala Ala
Gly Lys Thr Tyr Met Ile Phe Phe Val Val 370 375 380Val Ile Phe Leu
Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val385 390 395 400Val
Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 405 410
415Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys
420 425 430Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu
Tyr Thr 435 440 445Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu
Ser Ser Ser Glu 450 455 460Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys
Glu Arg Arg Asn Arg Arg465 470 475 480Lys Lys Lys Asn Gln Lys Lys
Leu Ser Ser Gly Glu Glu Lys Gly Asp 485 490 495Ala Glu Lys Leu Ser
Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 500 505 510Ser Phe His
Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 515 520 525Leu
Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 530 535
540Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly
Arg545 550 555 560Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp
Asp Glu His Ser 565 570 575Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly
Ser Leu Phe Val Pro His 580 585 590Arg Pro Gln Glu Arg Arg Ser Ser
Asn Ile Ser Gln Ala Ser Arg Ser 595 600 605Pro Pro Met Leu Pro Val
Asn Gly Lys Met His Ser Ala Val Asp Cys 610 615 620Asn Gly Val Val
Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro625 630 635 640Asn
Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 645 650
655Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro
660 665 670Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr
Asn Thr 675 680 685Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro
Pro Trp Trp Tyr 690 695 700Arg Phe Ala His Lys Phe Leu Ile Trp Asn
Cys Ser Pro Tyr Trp Ile705 710 715 720Lys Phe Lys Lys Cys Ile Tyr
Phe Ile Val Met Asp Pro Phe Val Asp 725 730 735Leu Ala Ile Thr Ile
Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 740 745 750Glu His His
Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 755 760 765Asn
Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 770 775
780Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile
Phe785 790 795 800Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu
Phe Leu Ala Asp 805 810 815Val Glu Gly Leu Ser Val Leu Arg Ser Phe
Arg Leu Leu Arg Val Phe 820 825 830Lys Leu Ala Lys Ser Trp Pro Thr
Leu Asn Met Leu Ile Lys Ile Ile 835 840 845Gly Asn Ser Val Gly Ala
Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 850 855 860Ile Val Phe Ile
Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser865 870 875 880Tyr
Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 885 890
895Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val
900 905 910Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu
Val Ala 915 920 925Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val
Met Val Ile Gly 930 935 940Asn Leu Val Val Leu Asn Leu Phe Leu Ala
Leu Leu Leu Ser Ser Phe945 950 955 960Ser Ser Asp Asn Leu Thr Ala
Ile Glu Glu Asp Pro Asp Ala Asn Asn 965 970 975Leu Gln Ile Ala Val
Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 980 985 990Gln Thr Leu
Arg Glu Phe Ile Leu Lys Ala Phe Ser Lys Lys Pro Lys 995 1000
1005Ile Ser Arg Glu Ile Arg Gln Ala Glu Asp Leu Asn Thr Lys Lys
1010 1015 1020Glu Asn Tyr Ile Ser Asn His Thr Leu Ala Glu Met Ser
Lys Gly 1025 1030 1035His Asn Phe Leu Lys Glu Lys Asp Lys Ile Ser
Gly Phe Gly Ser 1040 1045 1050Ser Val Asp Lys His Leu Met Glu Asp
Ser Asp Gly Gln Ser Phe 1055 1060 1065Ile His Asn Pro Ser Leu Thr
Val Thr Val Pro Ile Ala Pro Gly 1070 1075 1080Glu Ser Asp Leu Glu
Asn Met Asn Ala Glu Glu Leu Ser Ser Asp 1085 1090 1095Ser Asp Ser
Glu Tyr Ser Lys Val Arg Leu Asn Arg Ser Ser Ser 1100 1105 1110Ser
Glu Cys Ser Thr Val Asp Asn Pro Leu Pro Gly Glu Gly Glu 1115 1120
1125Glu Ala Glu Ala Glu Pro Met Asn Ser Asp Glu Pro Glu Ala Cys
1130 1135 1140Phe Thr Asp Gly Cys Val Trp Arg Phe Ser Cys Cys Gln
Val Asn 1145 1150 1155Ile Glu Ser Gly Lys Gly Lys Ile Trp Trp Asn
Ile Arg Lys Thr 1160 1165 1170Cys Tyr Lys Ile Val Glu His Ser Trp
Phe Glu Ser Phe Ile Val 1175 1180 1185Leu Met Ile Leu Leu Ser Ser
Gly Ala Leu Ala Phe Glu Asp Ile 1190 1195 1200Tyr Ile Glu Arg Lys
Lys Thr Ile Lys Ile Ile Leu Glu Tyr Ala 1205 1210 1215Asp Lys Ile
Phe Thr Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys 1220 1225 1230Trp
Ile Ala Tyr Gly Tyr Lys Thr Tyr Phe Thr Asn Ala Trp Cys 1235 1240
1245Trp Leu Asp Phe Leu Ile Val Asp Val Ser Leu Val Thr Leu Val
1250 1255 1260Ala Asn Thr Leu Gly Tyr Ser Asp Leu Gly Pro Ile Lys
Ser Leu 1265 1270 1275Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg Ala
Leu Ser Arg Phe 1280 1285 1290Glu Gly Met Arg Val Val Val Asn Ala
Leu Ile Gly Ala Ile Pro 1295 1300 1305Ser Ile Met Asn Val Leu Leu
Val Cys Leu Ile Phe Trp Leu Ile 1310 1315 1320Phe Ser Ile Met Gly
Val Asn Leu Phe Ala Gly Lys Phe Tyr Glu 1325 1330 1335Cys Ile Asn
Thr Thr Asp Gly Ser Arg Phe Pro Ala Ser Gln Val 1340 1345 1350Pro
Asn Arg Ser Glu Cys Phe Ala Leu Met Asn Val Ser Gln Asn 1355 1360
1365Val Arg Trp Lys Asn Leu Lys Val Asn Phe Asp Asn Val Gly Leu
1370 1375 1380Gly Tyr Leu Ser Leu Leu Gln Val Ala Thr Phe Lys Gly
Trp Thr 1385 1390 1395Ile Ile Met Tyr Ala Ala Val Asp Ser Val Asn
Val Asp
Lys Gln 1400 1405 1410Pro Lys Tyr Glu Tyr Ser Leu Tyr Met Tyr Ile
Tyr Phe Val Val 1415 1420 1425Phe Ile Ile Phe Gly Ser Phe Phe Thr
Leu Asn Leu Phe Ile Gly 1430 1435 1440Val Ile Ile Asp Asn Phe Asn
Gln Gln Lys Lys Lys Leu Gly Gly 1445 1450 1455Gln Asp Ile Phe Met
Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala 1460 1465 1470Met Lys Lys
Leu Gly Ser Lys Lys Pro Gln Lys Pro Ile Pro Arg 1475 1480 1485Pro
Gly Asn Lys Ile Gln Gly Cys Ile Phe Asp Leu Val Thr Asn 1490 1495
1500Gln Ala Phe Asp Ile Ser Ile Met Val Leu Ile Cys Leu Asn Met
1505 1510 1515Val Thr Met Met Val Glu Lys Glu Gly Gln Ser Gln His
Met Thr 1520 1525 1530Glu Val Leu Tyr Trp Ile Asn Val Val Phe Ile
Ile Leu Phe Thr 1535 1540 1545Gly Glu Cys Val Leu Lys Leu Ile Ser
Leu Arg His Tyr Tyr Phe 1550 1555 1560Thr Val Gly Trp Asn Ile Phe
Asp Phe Val Val Val Ile Ile Ser 1565 1570 1575Ile Val Gly Met Phe
Leu Ala Asp Leu Ile Glu Thr Tyr Phe Val 1580 1585 1590Ser Pro Thr
Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg 1595 1600 1605Ile
Leu Arg Leu Val Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu 1610 1615
1620Phe Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu
1625 1630 1635Leu Leu Phe Leu Val Met Phe Ile Tyr Ala Ile Phe Gly
Met Ser 1640 1645 1650Asn Phe Ala Tyr Val Lys Lys Glu Asp Gly Ile
Asn Asp Met Phe 1655 1660 1665Asn Phe Glu Thr Phe Gly Asn Ser Met
Ile Cys Leu Phe Gln Ile 1670 1675 1680Thr Thr Ser Ala Gly Trp Asp
Gly Leu Leu Ala Pro Ile Leu Asn 1685 1690 1695Ser Lys Pro Pro Asp
Cys Asp Pro Lys Lys Val His Pro Gly Ser 1700 1705 1710Ser Val Glu
Gly Asp Cys Gly Asn Pro Ser Val Gly Ile Phe Tyr 1715 1720 1725Phe
Val Ser Tyr Ile Ile Ile Ser Phe Leu Val Val Val Asn Met 1730 1735
1740Tyr Ile Ala Val Ile Leu Glu Asn Phe Ser Val Ala Thr Glu Glu
1745 1750 1755Ser Thr Glu Pro Leu Ser Glu Asp Asp Phe Glu Met Phe
Tyr Glu 1760 1765 1770Val Trp Glu Lys Phe Asp Pro Asp Ala Thr Gln
Phe Ile Glu Phe 1775 1780 1785Ser Lys Leu Ser Asp Phe Ala Ala Ala
Leu Asp Pro Pro Leu Leu 1790 1795 1800Ile Ala Lys Pro Asn Lys Val
Gln Leu Ile Ala Met Asp Leu Pro 1805 1810 1815Met Val Ser Gly Asp
Arg Ile His Cys Leu Asp Ile Leu Phe Ala 1820 1825 1830Phe Thr Lys
Arg Val Leu Gly Glu Ser Gly Glu Met Asp Ser Leu 1835 1840 1845Arg
Ser Gln Met Glu Glu Arg Phe Met Ser Ala Asn Pro Ser Lys 1850 1855
1860Val Ser Tyr Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu
1865 1870 1875Asp Val Ser Ala Thr Val Ile Gln Arg Ala Tyr Arg Arg
Tyr Arg 1880 1885 1890Leu Arg Gln Asn Val Lys Asn Ile Ser Ser Ile
Tyr Ile Lys Asp 1895 1900 1905Gly Asp Arg Asp Asp Asp Leu Leu Asn
Lys Lys Asp Met Ala Phe 1910 1915 1920Asp Asn Val Asn Glu Asn Ser
Ser Pro Glu Lys Thr Asp Ala Thr 1925 1930 1935Ser Ser Thr Thr Ser
Pro Pro Ser Tyr Asp Ser Val Thr Lys Pro 1940 1945 1950Asp Lys Glu
Lys Tyr Glu Gln Asp Arg Thr Glu Lys Glu Asp Lys 1955 1960 1965Gly
Lys Asp Ser Lys Glu Ser Lys Lys 1970 197536367DNAHomo sapiens
3ctcttatgtg aggagctgaa gaggaattaa aatatacagg atgaaaagat ggcaatgttg
60cctcccccag gacctcagag ctttgtccat ttcacaaaac agtctcttgc cctcattgaa
120caacgcattg ctgaaagaaa atcaaaggaa cccaaagaag aaaagaaaga
tgatgatgaa 180gaagccccaa agccaagcag tgacttggaa gctggcaaac
aactgccctt catctatggg 240gacattcctc ccggcatggt gtcagagccc
ctggaggact tggaccccta ctatgcagac 300aaaaagactt tcatagtatt
gaacaaaggg aaaacaatct tccgtttcaa tgccacacct 360gctttatata
tgctttctcc tttcagtcct ctaagaagaa tatctattaa gattttagta
420cactccttat tcagcatgct catcatgtgc actattctga caaactgcat
atttatgacc 480atgaataacc cgccggactg gaccaaaaat gtcgagtaca
cttttactgg aatatatact 540tttgaatcac ttgtaaaaat ccttgcaaga
ggcttctgtg taggagaatt cacttttctt 600cgtgacccgt ggaactggct
ggattttgtc gtcattgttt ttgcatatgt gacagagttt 660gtggacctgg
gcaatgtctc agcattgaga acattcagag ttctccgagc attgaaaaca
720atttcagtca ttccaggcct gaagacaatt gtaggggctt tgatccagtc
agtgaagaag 780ctttctgatg tcatgatcct gactgtgttc tgtctgagtg
tgtttgcact aattggacta 840cagctgttca tgggaaacct gaagcataaa
tgttttcgaa attcacttga aaataatgaa 900acattagaaa gcataatgaa
taccctagag agtgaagaag actttagaaa atatttttat 960tacttggaag
gatccaaaga tgctctcctt tgtggtttca gcacagattc aggtcagtgt
1020ccagaggggt acacctgtgt gaaaattggc agaaaccctg attatggcta
cacgagcttt 1080gacactttca gctgggcctt cttagccttg tttaggctaa
tgacccaaga ttactgggaa 1140aacctttacc aacagacgct gcgtgccgct
ggcaaaacct acatgatctt ctttgtcgta 1200gtgattttcc tgggctcctt
ttatctaata aacttgatcc tggctgtggt tgccatggca 1260tatgaagaac
agaaccaggc aaacattgaa gaagctaaac agaaagaatt agagtttcaa
1320cagatgttag accgacttaa aaaagagcaa gaagaagctg aggcaattgc
agcggcagcg 1380gctgaatata caagtattag gagaagcaga attatgggcc
tctcagagag ttcttctgaa 1440acatccaaac tgagctctaa aagtgctaaa
gaaagaagaa acagaagaaa gaaaaagaat 1500caaaagaagc tctccagtgg
agaggaaaag ggagatgctg agaaattgtc gaaatcagaa 1560tcagaggaca
gcatcagaag aaaaagtttc caccttggtg tcgaagggca taggcgagca
1620catgaaaaga ggttgtctac ccccaatcag tcaccactca gcattcgtgg
ctccttgttt 1680tctgcaaggc gaagcagcag aacaagtctt tttagtttca
aaggcagagg aagagatata 1740ggatctgaga ctgaatttgc cgatgatgag
cacagcattt ttggagacaa tgagagcaga 1800aggggctcac tgtttgtgcc
ccacagaccc caggagcgac gcagcagtaa catcagccaa 1860gccagtaggt
ccccaccaat gctgccggtg aacgggaaaa tgcacagtgc tgtggactgc
1920aacggtgtgg tctccctggt tgatggacgc tcagccctca tgctccccaa
tggacagctt 1980ctgccagagg gcacgaccaa tcaaatacac aagaaaaggc
gttgtagttc ctatctcctt 2040tcagaggata tgctgaatga tcccaacctc
agacagagag caatgagtag agcaagcata 2100ttaacaaaca ctgtggaaga
acttgaagag tccagacaaa aatgtccacc ttggtggtac 2160agatttgcac
acaaattctt gatctggaat tgctctccat attggataaa attcaaaaag
2220tgtatctatt ttattgtaat ggatcctttt gtagatcttg caattaccat
ttgcatagtt 2280ttaaacacat tatttatggc tatggaacac cacccaatga
ctgaggaatt caaaaatgta 2340cttgctatag gaaatttggt ctttactgga
atctttgcag ctgaaatggt attaaaactg 2400attgccatgg atccatatga
gtatttccaa gtaggctgga atatttttga cagccttatt 2460gtgactttaa
gtttagtgga gctctttcta gcagatgtgg aaggattgtc agttctgcga
2520tcattcagac tgctccgagt cttcaagttg gcaaaatcct ggccaacatt
gaacatgctg 2580attaagatca ttggtaactc agtaggggct ctaggtaacc
tcaccttagt gttggccatc 2640atcgtcttca tttttgctgt ggtcggcatg
cagctctttg gtaagagcta caaagaatgt 2700gtctgcaaga tcaatgatga
ctgtacgctc ccacggtggc acatgaacga cttcttccac 2760tccttcctga
ttgtgttccg cgtgctgtgt ggagagtgga tagagaccat gtgggactgt
2820atggaggtcg ctggtcaagc tatgtgcctt attgtttaca tgatggtcat
ggtcattgga 2880aacctggtgg tcctaaacct atttctggcc ttattattga
gctcatttag ttcagacaat 2940cttacagcaa ttgaagaaga ccctgatgca
aacaacctcc agattgcagt gactagaatt 3000aaaaagggaa taaattatgt
gaaacaaacc ttacgtgaat ttattctaaa agcattttcc 3060aaaaagccaa
agatttccag ggagataaga caagcagaag atctgaatac taagaaggaa
3120aactatattt ctaaccatac acttgctgaa atgagcaaag gtcacaattt
cctcaaggaa 3180aaagataaaa tcagtggttt tggaagcagc gtggacaaac
acttgatgga agacagtgat 3240ggtcaatcat ttattcacaa tcccagcctc
acagtgacag tgccaattgc acctggggaa 3300tccgatttgg aaaatatgaa
tgctgaggaa cttagcagtg attcggatag tgaatacagc 3360aaagtgagat
taaaccggtc aagctcctca gagtgcagca cagttgataa ccctttgcct
3420ggagaaggag aagaagcaga ggctgaacct atgaattccg atgagccaga
ggcctgtttc 3480acagatggtt gtgtacggag gttctcatgc tgccaagtta
acatagagtc agggaaagga 3540aaaatctggt ggaacatcag gaaaacctgc
tacaagattg ttgaacacag ttggtttgaa 3600agcttcattg tcctcatgat
cctgctcagc agtggtgccc tggcttttga agatatttat 3660attgaaagga
aaaagaccat taagattatc ctggagtatg cagacaagat cttcacttac
3720atcttcattc tggaaatgct tctaaaatgg atagcatatg gttataaaac
atatttcacc 3780aatgcctggt gttggctgga tttcctaatt gttgatgttt
ctttggttac tttagtggca 3840aacactcttg gctactcaga tcttggcccc
attaaatccc ttcggacact gagagcttta 3900agacctctaa gagccttatc
tagatttgaa ggaatgaggg tcgttgtgaa tgcactcata 3960ggagcaattc
cttccatcat gaatgtgcta cttgtgtgtc ttatattctg gctgatattc
4020agcatcatgg gagtaaattt gtttgctggc aagttctatg agtgtattaa
caccacagat 4080gggtcacggt ttcctgcaag tcaagttcca aatcgttccg
aatgttttgc ccttatgaat 4140gttagtcaaa atgtgcgatg gaaaaacctg
aaagtgaact ttgataatgt cggacttggt 4200tacctatctc tgcttcaagt
tgcaactttt aagggatgga cgattattat gtatgcagca 4260gtggattctg
ttaatgtaga caagcagccc aaatatgaat atagcctcta catgtatatt
4320tattttgtcg tctttatcat ctttgggtca ttcttcactt tgaacttgtt
cattggtgtc 4380atcatagata atttcaacca acagaaaaag aagcttggag
gtcaagacat ctttatgaca 4440gaagaacaga agaaatacta taatgcaatg
aaaaagctgg ggtccaagaa gccacaaaag 4500ccaattcctc gaccagggaa
caaaatccaa ggatgtatat ttgacctagt gacaaatcaa 4560gcctttgata
ttagtatcat ggttcttatc tgtctcaaca tggtaaccat gatggtagaa
4620aaggagggtc aaagtcaaca tatgactgaa gttttatatt ggataaatgt
ggtttttata 4680atccttttca ctggagaatg tgtgctaaaa ctgatctccc
tcagacacta ctacttcact 4740gtaggatgga atatttttga ttttgtggtt
gtgattatct ccattgtagg tatgtttcta 4800gctgatttga ttgaaacgta
ttttgtgtcc cctaccctgt tccgagtgat ccgtcttgcc 4860aggattggcc
gaatcctacg tctagtcaaa ggagcaaagg ggatccgcac gctgctcttt
4920gctttgatga tgtcccttcc tgcgttgttt aacatcggcc tcctgctctt
cctggtcatg 4980ttcatctacg ccatctttgg aatgtccaac tttgcctatg
ttaaaaagga agatggaatt 5040aatgacatgt tcaattttga gacctttggc
aacagtatga tttgcctgtt ccaaattaca 5100acctctgctg gctgggatgg
attgctagca cctattctta acagtaagcc acccgactgt 5160gacccaaaaa
aagttcatcc tggaagttca gttgaaggag actgtggtaa cccatctgtt
5220ggaatattct actttgttag ttatatcatc atatccttcc tggttgtggt
gaacatgtac 5280attgcagtca tactggagaa ttttagtgtt gccactgaag
aaagtactga acctctgagt 5340gaggatgact ttgagatgtt ctatgaggtt
tgggagaagt ttgatcccga tgcgacccag 5400tttatagagt tctctaaact
ctctgatttt gcagctgccc tggatcctcc tcttctcata 5460gcaaaaccca
acaaagtcca gctcattgcc atggatctgc ccatggttag tggtgaccgg
5520atccattgtc ttgacatctt atttgctttt acaaagcgtg ttttgggtga
gagtggggag 5580atggattctc ttcgttcaca gatggaagaa aggttcatgt
ctgcaaatcc ttccaaagtg 5640tcctatgaac ccatcacaac cacactaaaa
cggaaacaag aggatgtgtc tgctactgtc 5700attcagcgtg cttatagacg
ttaccgctta aggcaaaatg tcaaaaatat atcaagtata 5760tacataaaag
atggagacag agatgatgat ttactcaata aaaaagatat ggcttttgat
5820aatgttaatg agaactcaag tccagaaaaa acagatgcca cttcatccac
cacctctcca 5880ccttcatatg atagtgtaac aaagccagac aaagagaaat
atgaacaaga cagaacagaa 5940aaggaagaca aagggaaaga cagcaaggaa
agcaaaaaat agagcttcat ttttgatata 6000ttgtttacag cctgtgaaag
tgatttattt gtgttaataa aactcttttg aggaagtcta 6060tgccaaaatc
ctttttatca aaatattctc gaaggcagtg cagtcactaa ctctgatttc
6120ctaagaaagg tgggcagcat tagcagatgg ttatttttgc actgatgatt
ctttaagaat 6180cgtaagagaa ctctgtagga attattgatt atagcataca
aaagtgattc agttttttgg 6240tttttaataa atcagaagac catgtagaaa
acttttacat ctgccttgtc atcttttcac 6300aggattgtaa ttagtcttgt
ttcccatgta aataaacaac acacgcatac agaaaaaaaa 6360aaaaaaa
636741977PRTHomo sapiens 4Met Ala Met Leu Pro Pro Pro Gly Pro Gln
Ser Phe Val His Phe Thr1 5 10 15Lys Gln Ser Leu Ala Leu Ile Glu Gln
Arg Ile Ala Glu Arg Lys Ser 20 25 30Lys Glu Pro Lys Glu Glu Lys Lys
Asp Asp Asp Glu Glu Ala Pro Lys 35 40 45Pro Ser Ser Asp Leu Glu Ala
Gly Lys Gln Leu Pro Phe Ile Tyr Gly 50 55 60Asp Ile Pro Pro Gly Met
Val Ser Glu Pro Leu Glu Asp Leu Asp Pro65 70 75 80Tyr Tyr Ala Asp
Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 85 90 95Ile Phe Arg
Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 100 105 110Ser
Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 115 120
125Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr
130 135 140Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr
Phe Thr145 150 155 160Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile
Leu Ala Arg Gly Phe 165 170 175Cys Val Gly Glu Phe Thr Phe Leu Arg
Asp Pro Trp Asn Trp Leu Asp 180 185 190Phe Val Val Ile Val Phe Ala
Tyr Val Thr Glu Phe Val Asp Leu Gly 195 200 205Asn Val Ser Ala Leu
Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 210 215 220Ile Ser Val
Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln225 230 235
240Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu
245 250 255Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn
Leu Lys 260 265 270His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu
Thr Leu Glu Ser 275 280 285Ile Met Asn Thr Leu Glu Ser Glu Glu Asp
Phe Arg Lys Tyr Phe Tyr 290 295 300Tyr Leu Glu Gly Ser Lys Asp Ala
Leu Leu Cys Gly Phe Ser Thr Asp305 310 315 320Ser Gly Gln Cys Pro
Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 325 330 335Pro Asp Tyr
Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 340 345 350Ala
Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 355 360
365Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val
370 375 380Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu
Ala Val385 390 395 400Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala
Asn Ile Glu Glu Ala 405 410 415Lys Gln Lys Glu Leu Glu Phe Gln Gln
Met Leu Asp Arg Leu Lys Lys 420 425 430Glu Gln Glu Glu Ala Glu Ala
Ile Ala Ala Ala Ala Ala Glu Tyr Thr 435 440 445Ser Ile Arg Arg Ser
Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 450 455 460Thr Ser Lys
Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg465 470 475
480Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp
485 490 495Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg
Arg Lys 500 505 510Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala
His Glu Lys Arg 515 520 525Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser
Ile Arg Gly Ser Leu Phe 530 535 540Ser Ala Arg Arg Ser Ser Arg Thr
Ser Leu Phe Ser Phe Lys Gly Arg545 550 555 560Gly Arg Asp Ile Gly
Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 565 570 575Ile Phe Gly
Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 580 585 590Arg
Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 595 600
605Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys
610 615 620Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met
Leu Pro625 630 635 640Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn
Gln Ile His Lys Lys 645 650 655Arg Arg Cys Ser Ser Tyr Leu Leu Ser
Glu Asp Met Leu Asn Asp Pro 660 665 670Asn Leu Arg Gln Arg Ala Met
Ser Arg Ala Ser Ile Leu Thr Asn Thr 675 680 685Val Glu Glu Leu Glu
Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 690 695 700Arg Phe Ala
His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile705 710 715
720Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp
725 730 735Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met
Ala Met 740 745 750Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val
Leu Ala Ile Gly 755 760 765Asn Leu Val Phe Thr Gly Ile Phe Ala Ala
Glu Met Val Leu Lys Leu 770 775 780Ile Ala Met Asp Pro Tyr Glu Tyr
Phe Gln Val Gly Trp Asn Ile Phe785 790 795 800Asp Ser Leu Ile Val
Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 805 810 815Val Glu Gly
Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 820 825
830Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile
835 840 845Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu
Ala Ile 850 855 860Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu
Phe Gly Lys Ser865 870 875 880Tyr Lys Glu Cys Val Cys Lys Ile Asn
Asp Asp Cys Thr Leu Pro Arg 885 890 895Trp His Met Asn Asp Phe Phe
His Ser Phe Leu Ile Val Phe Arg Val 900 905 910Leu Cys Gly Glu Trp
Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 915 920 925Gly Gln Ala
Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 930 935 940Asn
Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe945 950
955 960Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn
Asn 965 970 975Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn
Tyr Val Lys 980 985 990Gln Thr Leu Arg Glu Phe Ile Leu Lys Ala Phe
Ser Lys Lys Pro Lys 995 1000 1005Ile Ser Arg Glu Ile Arg Gln Ala
Glu Asp Leu Asn Thr Lys Lys 1010 1015 1020Glu Asn Tyr Ile Ser Asn
His Thr Leu Ala Glu Met Ser Lys Gly 1025 1030 1035His Asn Phe Leu
Lys Glu Lys Asp Lys Ile Ser Gly Phe Gly Ser 1040 1045 1050Ser Val
Asp Lys His Leu Met Glu Asp Ser Asp Gly Gln Ser Phe 1055 1060
1065Ile His Asn Pro Ser Leu Thr Val Thr Val Pro Ile Ala Pro Gly
1070 1075 1080Glu Ser Asp Leu Glu Asn Met Asn Ala Glu Glu Leu Ser
Ser Asp 1085 1090 1095Ser Asp Ser Glu Tyr Ser Lys Val Arg Leu Asn
Arg Ser Ser Ser 1100 1105 1110Ser Glu Cys Ser Thr Val Asp Asn Pro
Leu Pro Gly Glu Gly Glu 1115 1120 1125Glu Ala Glu Ala Glu Pro Met
Asn Ser Asp Glu Pro Glu Ala Cys 1130 1135 1140Phe Thr Asp Gly Cys
Val Arg Arg Phe Ser Cys Cys Gln Val Asn 1145 1150 1155Ile Glu Ser
Gly Lys Gly Lys Ile Trp Trp Asn Ile Arg Lys Thr 1160 1165 1170Cys
Tyr Lys Ile Val Glu His Ser Trp Phe Glu Ser Phe Ile Val 1175 1180
1185Leu Met Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile
1190 1195 1200Tyr Ile Glu Arg Lys Lys Thr Ile Lys Ile Ile Leu Glu
Tyr Ala 1205 1210 1215Asp Lys Ile Phe Thr Tyr Ile Phe Ile Leu Glu
Met Leu Leu Lys 1220 1225 1230Trp Ile Ala Tyr Gly Tyr Lys Thr Tyr
Phe Thr Asn Ala Trp Cys 1235 1240 1245Trp Leu Asp Phe Leu Ile Val
Asp Val Ser Leu Val Thr Leu Val 1250 1255 1260Ala Asn Thr Leu Gly
Tyr Ser Asp Leu Gly Pro Ile Lys Ser Leu 1265 1270 1275Arg Thr Leu
Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser Arg Phe 1280 1285 1290Glu
Gly Met Arg Val Val Val Asn Ala Leu Ile Gly Ala Ile Pro 1295 1300
1305Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe Trp Leu Ile
1310 1315 1320Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe
Tyr Glu 1325 1330 1335Cys Ile Asn Thr Thr Asp Gly Ser Arg Phe Pro
Ala Ser Gln Val 1340 1345 1350Pro Asn Arg Ser Glu Cys Phe Ala Leu
Met Asn Val Ser Gln Asn 1355 1360 1365Val Arg Trp Lys Asn Leu Lys
Val Asn Phe Asp Asn Val Gly Leu 1370 1375 1380Gly Tyr Leu Ser Leu
Leu Gln Val Ala Thr Phe Lys Gly Trp Thr 1385 1390 1395Ile Ile Met
Tyr Ala Ala Val Asp Ser Val Asn Val Asp Lys Gln 1400 1405 1410Pro
Lys Tyr Glu Tyr Ser Leu Tyr Met Tyr Ile Tyr Phe Val Val 1415 1420
1425Phe Ile Ile Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly
1430 1435 1440Val Ile Ile Asp Asn Phe Asn Gln Gln Lys Lys Lys Leu
Gly Gly 1445 1450 1455Gln Asp Ile Phe Met Thr Glu Glu Gln Lys Lys
Tyr Tyr Asn Ala 1460 1465 1470Met Lys Lys Leu Gly Ser Lys Lys Pro
Gln Lys Pro Ile Pro Arg 1475 1480 1485Pro Gly Asn Lys Ile Gln Gly
Cys Ile Phe Asp Leu Val Thr Asn 1490 1495 1500Gln Ala Phe Asp Ile
Ser Ile Met Val Leu Ile Cys Leu Asn Met 1505 1510 1515Val Thr Met
Met Val Glu Lys Glu Gly Gln Ser Gln His Met Thr 1520 1525 1530Glu
Val Leu Tyr Trp Ile Asn Val Val Phe Ile Ile Leu Phe Thr 1535 1540
1545Gly Glu Cys Val Leu Lys Leu Ile Ser Leu Arg His Tyr Tyr Phe
1550 1555 1560Thr Val Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile
Ile Ser 1565 1570 1575Ile Val Gly Met Phe Leu Ala Asp Leu Ile Glu
Thr Tyr Phe Val 1580 1585 1590Ser Pro Thr Leu Phe Arg Val Ile Arg
Leu Ala Arg Ile Gly Arg 1595 1600 1605Ile Leu Arg Leu Val Lys Gly
Ala Lys Gly Ile Arg Thr Leu Leu 1610 1615 1620Phe Ala Leu Met Met
Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu 1625 1630 1635Leu Leu Phe
Leu Val Met Phe Ile Tyr Ala Ile Phe Gly Met Ser 1640 1645 1650Asn
Phe Ala Tyr Val Lys Lys Glu Asp Gly Ile Asn Asp Met Phe 1655 1660
1665Asn Phe Glu Thr Phe Gly Asn Ser Met Ile Cys Leu Phe Gln Ile
1670 1675 1680Thr Thr Ser Ala Gly Trp Asp Gly Leu Leu Ala Pro Ile
Leu Asn 1685 1690 1695Ser Lys Pro Pro Asp Cys Asp Pro Lys Lys Val
His Pro Gly Ser 1700 1705 1710Ser Val Glu Gly Asp Cys Gly Asn Pro
Ser Val Gly Ile Phe Tyr 1715 1720 1725Phe Val Ser Tyr Ile Ile Ile
Ser Phe Leu Val Val Val Asn Met 1730 1735 1740Tyr Ile Ala Val Ile
Leu Glu Asn Phe Ser Val Ala Thr Glu Glu 1745 1750 1755Ser Thr Glu
Pro Leu Ser Glu Asp Asp Phe Glu Met Phe Tyr Glu 1760 1765 1770Val
Trp Glu Lys Phe Asp Pro Asp Ala Thr Gln Phe Ile Glu Phe 1775 1780
1785Ser Lys Leu Ser Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu Leu
1790 1795 1800Ile Ala Lys Pro Asn Lys Val Gln Leu Ile Ala Met Asp
Leu Pro 1805 1810 1815Met Val Ser Gly Asp Arg Ile His Cys Leu Asp
Ile Leu Phe Ala 1820 1825 1830Phe Thr Lys Arg Val Leu Gly Glu Ser
Gly Glu Met Asp Ser Leu 1835 1840 1845Arg Ser Gln Met Glu Glu Arg
Phe Met Ser Ala Asn Pro Ser Lys 1850 1855 1860Val Ser Tyr Glu Pro
Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu 1865 1870 1875Asp Val Ser
Ala Thr Val Ile Gln Arg Ala Tyr Arg Arg Tyr Arg 1880 1885 1890Leu
Arg Gln Asn Val Lys Asn Ile Ser Ser Ile Tyr Ile Lys Asp 1895 1900
1905Gly Asp Arg Asp Asp Asp Leu Leu Asn Lys Lys Asp Met Ala Phe
1910 1915 1920Asp Asn Val Asn Glu Asn Ser Ser Pro Glu Lys Thr Asp
Ala Thr 1925 1930 1935Ser Ser Thr Thr Ser Pro Pro Ser Tyr Asp Ser
Val Thr Lys Pro 1940 1945 1950Asp Lys Glu Lys Tyr Glu Gln Asp Arg
Thr Glu Lys Glu Asp Lys 1955 1960 1965Gly Lys Asp Ser Lys Glu Ser
Lys Lys 1970 197556397DNAHomo sapiens 5ctcttatgtg aggagctgaa
gaggaattaa aatatacagg atgaaaagat ggcaatgttg 60cctcccccag gacctcagag
ctttgtccat ttcacaaaac agtctcttgc cctcattgaa 120caacgcattg
ctgaaagaaa atcaaaggaa cccaaagaag aaaagaaaga tgatgatgaa
180gaagccccaa agccaagcag tgacttggaa gctggcaaac aactgccctt
catctatggg 240gacattcctc ccggcatggt gtcagagccc ctggaggact
tggaccccta ctatgcagac 300aaaaagactt tcatagtatt gaacaaaggg
aaaacaatct tccgtttcaa tgccacacct 360gctttatata tgctttctcc
tttcagtcct ctaagaagaa tatctattaa gattttagta 420cactccttat
tcagcatgct catcatgtgc actattctga caaactgcat atttatgacc
480atgaataacc cgccggactg gaccaaaaat gtcgagtaca cttttactgg
aatatatact 540tttgaatcac ttgtaaaaat ccttgcaaga ggcttctgtg
taggagaatt cacttttctt 600cgtgacccgt ggaactggct ggattttgtc
gtcattgttt ttgcgtattt aacagaattt 660gtaaacctag gcaatgtttc
agctcttcga actttcagag tattgagagc tttgaaaact 720atttctgtaa
tcccaggcct gaagacaatt gtaggggctt tgatccagtc agtgaagaag
780ctttctgatg tcatgatcct gactgtgttc tgtctgagtg tgtttgcact
aattggacta 840cagctgttca tgggaaacct gaagcataaa tgttttcgaa
attcacttga aaataatgaa 900acattagaaa gcataatgaa taccctagag
agtgaagaag actttagaaa atatttttat 960tacttggaag gatccaaaga
tgctctcctt tgtggtttca gcacagattc aggtcagtgt 1020ccagaggggt
acacctgtgt gaaaattggc agaaaccctg attatggcta cacgagcttt
1080gacactttca gctgggcctt cttagccttg tttaggctaa tgacccaaga
ttactgggaa 1140aacctttacc aacagacgct gcgtgccgct ggcaaaacct
acatgatctt ctttgtcgta 1200gtgattttcc tgggctcctt ttatctaata
aacttgatcc tggctgtggt tgccatggca 1260tatgaagaac agaaccaggc
aaacattgaa gaagctaaac agaaagaatt agagtttcaa 1320cagatgttag
accgacttaa aaaagagcaa gaagaagctg aggcaattgc agcggcagcg
1380gctgaatata caagtattag gagaagcaga attatgggcc tctcagagag
ttcttctgaa 1440acatccaaac tgagctctaa aagtgctaaa gaaagaagaa
acagaagaaa gaaaaagaat 1500caaaagaagc tctccagtgg agaggaaaag
ggagatgctg agaaattgtc gaaatcagaa 1560tcagaggaca gcatcagaag
aaaaagtttc caccttggtg tcgaagggca taggcgagca 1620catgaaaaga
ggttgtctac ccccaatcag tcaccactca gcattcgtgg ctccttgttt
1680tctgcaaggc gaagcagcag aacaagtctt tttagtttca aaggcagagg
aagagatata 1740ggatctgaga ctgaatttgc cgatgatgag cacagcattt
ttggagacaa tgagagcaga 1800aggggctcac tgtttgtgcc ccacagaccc
caggagcgac gcagcagtaa catcagccaa 1860gccagtaggt ccccaccaat
gctgccggtg aacgggaaaa tgcacagtgc tgtggactgc 1920aacggtgtgg
tctccctggt tgatggacgc tcagccctca tgctccccaa tggacagctt
1980ctgccagagg tgataataga taaggcaact tctgatgaca gcggcacgac
caatcaaata 2040cacaagaaaa ggcgttgtag ttcctatctc ctttcagagg
atatgctgaa tgatcccaac 2100ctcagacaga gagcaatgag tagagcaagc
atattaacaa acactgtgga agaacttgaa 2160gagtccagac aaaaatgtcc
accttggtgg tacagatttg cacacaaatt cttgatctgg 2220aattgctctc
catattggat aaaattcaaa aagtgtatct attttattgt aatggatcct
2280tttgtagatc ttgcaattac catttgcata gttttaaaca cattatttat
ggctatggaa 2340caccacccaa tgactgagga attcaaaaat gtacttgcta
taggaaattt ggtctttact 2400ggaatctttg cagctgaaat ggtattaaaa
ctgattgcca tggatccata tgagtatttc 2460caagtaggct ggaatatttt
tgacagcctt attgtgactt taagtttagt ggagctcttt 2520ctagcagatg
tggaaggatt gtcagttctg cgatcattca gactgctccg agtcttcaag
2580ttggcaaaat cctggccaac attgaacatg ctgattaaga tcattggtaa
ctcagtaggg 2640gctctaggta acctcacctt agtgttggcc atcatcgtct
tcatttttgc tgtggtcggc 2700atgcagctct ttggtaagag ctacaaagaa
tgtgtctgca agatcaatga tgactgtacg 2760ctcccacggt ggcacatgaa
cgacttcttc cactccttcc tgattgtgtt ccgcgtgctg 2820tgtggagagt
ggatagagac catgtgggac tgtatggagg tcgctggtca agctatgtgc
2880cttattgttt acatgatggt catggtcatt ggaaacctgg tggtcctaaa
cctatttctg 2940gccttattat tgagctcatt tagttcagac aatcttacag
caattgaaga agaccctgat 3000gcaaacaacc tccagattgc agtgactaga
attaaaaagg gaataaatta tgtgaaacaa 3060accttacgtg aatttattct
aaaagcattt tccaaaaagc caaagatttc cagggagata 3120agacaagcag
aagatctgaa tactaagaag gaaaactata tttctaacca tacacttgct
3180gaaatgagca aaggtcacaa tttcctcaag gaaaaagata aaatcagtgg
ttttggaagc 3240agcgtggaca aacacttgat ggaagacagt gatggtcaat
catttattca caatcccagc 3300ctcacagtga cagtgccaat tgcacctggg
gaatccgatt tggaaaatat gaatgctgag 3360gaacttagca gtgattcgga
tagtgaatac agcaaagtga gattaaaccg gtcaagctcc 3420tcagagtgca
gcacagttga taaccctttg cctggagaag gagaagaagc agaggctgaa
3480cctatgaatt ccgatgagcc agaggcctgt ttcacagatg gttgtgtacg
gaggttctca 3540tgctgccaag ttaacataga gtcagggaaa ggaaaaatct
ggtggaacat caggaaaacc 3600tgctacaaga ttgttgaaca cagttggttt
gaaagcttca ttgtcctcat gatcctgctc 3660agcagtggtg ccctggcttt
tgaagatatt tatattgaaa ggaaaaagac cattaagatt 3720atcctggagt
atgcagacaa gatcttcact tacatcttca ttctggaaat gcttctaaaa
3780tggatagcat atggttataa aacatatttc accaatgcct ggtgttggct
ggatttccta 3840attgttgatg tttctttggt tactttagtg gcaaacactc
ttggctactc agatcttggc 3900cccattaaat cccttcggac actgagagct
ttaagacctc taagagcctt atctagattt 3960gaaggaatga gggtcgttgt
gaatgcactc ataggagcaa ttccttccat catgaatgtg 4020ctacttgtgt
gtcttatatt ctggctgata ttcagcatca tgggagtaaa tttgtttgct
4080ggcaagttct atgagtgtat taacaccaca gatgggtcac ggtttcctgc
aagtcaagtt 4140ccaaatcgtt ccgaatgttt tgcccttatg aatgttagtc
aaaatgtgcg atggaaaaac 4200ctgaaagtga actttgataa tgtcggactt
ggttacctat ctctgcttca agttgcaact 4260tttaagggat ggacgattat
tatgtatgca gcagtggatt ctgttaatgt agacaagcag 4320cccaaatatg
aatatagcct ctacatgtat atttattttg tcgtctttat catctttggg
4380tcattcttca ctttgaactt gttcattggt gtcatcatag ataatttcaa
ccaacagaaa 4440aagaagcttg gaggtcaaga catctttatg acagaagaac
agaagaaata ctataatgca 4500atgaaaaagc tggggtccaa gaagccacaa
aagccaattc ctcgaccagg gaacaaaatc 4560caaggatgta tatttgacct
agtgacaaat caagcctttg atattagtat catggttctt 4620atctgtctca
acatggtaac catgatggta gaaaaggagg gtcaaagtca acatatgact
4680gaagttttat attggataaa tgtggttttt ataatccttt tcactggaga
atgtgtgcta 4740aaactgatct ccctcagaca ctactacttc actgtaggat
ggaatatttt tgattttgtg 4800gttgtgatta tctccattgt aggtatgttt
ctagctgatt tgattgaaac gtattttgtg 4860tcccctaccc tgttccgagt
gatccgtctt gccaggattg gccgaatcct acgtctagtc 4920aaaggagcaa
aggggatccg cacgctgctc tttgctttga tgatgtccct tcctgcgttg
4980tttaacatcg gcctcctgct cttcctggtc atgttcatct acgccatctt
tggaatgtcc 5040aactttgcct atgttaaaaa ggaagatgga attaatgaca
tgttcaattt tgagaccttt 5100ggcaacagta tgatttgcct gttccaaatt
acaacctctg ctggctggga tggattgcta 5160gcacctattc ttaacagtaa
gccacccgac tgtgacccaa aaaaagttca tcctggaagt 5220tcagttgaag
gagactgtgg taacccatct gttggaatat tctactttgt tagttatatc
5280atcatatcct tcctggttgt ggtgaacatg tacattgcag tcatactgga
gaattttagt 5340gttgccactg aagaaagtac tgaacctctg agtgaggatg
actttgagat gttctatgag 5400gtttgggaga agtttgatcc cgatgcgacc
cagtttatag agttctctaa actctctgat 5460tttgcagctg ccctggatcc
tcctcttctc atagcaaaac ccaacaaagt ccagctcatt 5520gccatggatc
tgcccatggt tagtggtgac cggatccatt gtcttgacat cttatttgct
5580tttacaaagc gtgttttggg tgagagtggg gagatggatt ctcttcgttc
acagatggaa 5640gaaaggttca tgtctgcaaa tccttccaaa gtgtcctatg
aacccatcac aaccacacta 5700aaacggaaac aagaggatgt gtctgctact
gtcattcagc gtgcttatag acgttaccgc 5760ttaaggcaaa atgtcaaaaa
tatatcaagt atatacataa aagatggaga cagagatgat 5820gatttactca
ataaaaaaga tatggctttt gataatgtta atgagaactc aagtccagaa
5880aaaacagatg ccacttcatc caccacctct ccaccttcat atgatagtgt
aacaaagcca 5940gacaaagaga aatatgaaca agacagaaca gaaaaggaag
acaaagggaa agacagcaag 6000gaaagcaaaa aatagagctt catttttgat
atattgttta cagcctgtga aagtgattta 6060tttgtgttaa taaaactctt
ttgaggaagt ctatgccaaa atccttttta tcaaaatatt 6120ctcgaaggca
gtgcagtcac taactctgat ttcctaagaa aggtgggcag cattagcaga
6180tggttatttt tgcactgatg attctttaag aatcgtaaga gaactctgta
ggaattattg 6240attatagcat acaaaagtga ttcagttttt tggtttttaa
taaatcagaa gaccatgtag 6300aaaactttta catctgcctt gtcatctttt
cacaggattg taattagtct tgtttcccat 6360gtaaataaac aacacacgca
tacagaaaaa aaaaaaa 639761988PRTHomo sapiens 6Met Ala Met Leu Pro
Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr1 5 10 15Lys Gln Ser Leu
Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 20 25 30Lys Glu Pro
Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 35 40 45Pro Ser
Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 50 55 60Asp
Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro65 70 75
80Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr
85 90 95Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro
Phe 100 105 110Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His
Ser Leu Phe 115 120 125Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn
Cys Ile Phe Met Thr 130 135 140Met Asn Asn Pro Pro Asp Trp Thr Lys
Asn Val Glu Tyr Thr Phe Thr145 150 155 160Gly Ile Tyr Thr Phe Glu
Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 165 170 175Cys Val Gly Glu
Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 180 185 190Phe Val
Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 195 200
205Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr
210 215 220Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu
Ile Gln225 230 235 240Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu
Thr Val Phe Cys Leu
245 250 255Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn
Leu Lys 260 265 270His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu
Thr Leu Glu Ser 275 280 285Ile Met Asn Thr Leu Glu Ser Glu Glu Asp
Phe Arg Lys Tyr Phe Tyr 290 295 300Tyr Leu Glu Gly Ser Lys Asp Ala
Leu Leu Cys Gly Phe Ser Thr Asp305 310 315 320Ser Gly Gln Cys Pro
Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 325 330 335Pro Asp Tyr
Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 340 345 350Ala
Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 355 360
365Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val
370 375 380Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu
Ala Val385 390 395 400Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala
Asn Ile Glu Glu Ala 405 410 415Lys Gln Lys Glu Leu Glu Phe Gln Gln
Met Leu Asp Arg Leu Lys Lys 420 425 430Glu Gln Glu Glu Ala Glu Ala
Ile Ala Ala Ala Ala Ala Glu Tyr Thr 435 440 445Ser Ile Arg Arg Ser
Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 450 455 460Thr Ser Lys
Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg465 470 475
480Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp
485 490 495Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg
Arg Lys 500 505 510Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala
His Glu Lys Arg 515 520 525Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser
Ile Arg Gly Ser Leu Phe 530 535 540Ser Ala Arg Arg Ser Ser Arg Thr
Ser Leu Phe Ser Phe Lys Gly Arg545 550 555 560Gly Arg Asp Ile Gly
Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 565 570 575Ile Phe Gly
Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 580 585 590Arg
Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 595 600
605Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys
610 615 620Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met
Leu Pro625 630 635 640Asn Gly Gln Leu Leu Pro Glu Val Ile Ile Asp
Lys Ala Thr Ser Asp 645 650 655Asp Ser Gly Thr Thr Asn Gln Ile His
Lys Lys Arg Arg Cys Ser Ser 660 665 670Tyr Leu Leu Ser Glu Asp Met
Leu Asn Asp Pro Asn Leu Arg Gln Arg 675 680 685Ala Met Ser Arg Ala
Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu 690 695 700Glu Ser Arg
Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys705 710 715
720Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys
725 730 735Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile
Thr Ile 740 745 750Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu
His His Pro Met 755 760 765Thr Glu Glu Phe Lys Asn Val Leu Ala Ile
Gly Asn Leu Val Phe Thr 770 775 780Gly Ile Phe Ala Ala Glu Met Val
Leu Lys Leu Ile Ala Met Asp Pro785 790 795 800Tyr Glu Tyr Phe Gln
Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val 805 810 815Thr Leu Ser
Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser 820 825 830Val
Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 835 840
845Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly
850 855 860Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe
Ile Phe865 870 875 880Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser
Tyr Lys Glu Cys Val 885 890 895Cys Lys Ile Asn Asp Asp Cys Thr Leu
Pro Arg Trp His Met Asn Asp 900 905 910Phe Phe His Ser Phe Leu Ile
Val Phe Arg Val Leu Cys Gly Glu Trp 915 920 925Ile Glu Thr Met Trp
Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys 930 935 940Leu Ile Val
Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu945 950 955
960Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu
965 970 975Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn Leu Gln Ile
Ala Val 980 985 990Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys Gln
Thr Leu Arg Glu 995 1000 1005Phe Ile Leu Lys Ala Phe Ser Lys Lys
Pro Lys Ile Ser Arg Glu 1010 1015 1020Ile Arg Gln Ala Glu Asp Leu
Asn Thr Lys Lys Glu Asn Tyr Ile 1025 1030 1035Ser Asn His Thr Leu
Ala Glu Met Ser Lys Gly His Asn Phe Leu 1040 1045 1050Lys Glu Lys
Asp Lys Ile Ser Gly Phe Gly Ser Ser Val Asp Lys 1055 1060 1065His
Leu Met Glu Asp Ser Asp Gly Gln Ser Phe Ile His Asn Pro 1070 1075
1080Ser Leu Thr Val Thr Val Pro Ile Ala Pro Gly Glu Ser Asp Leu
1085 1090 1095Glu Asn Met Asn Ala Glu Glu Leu Ser Ser Asp Ser Asp
Ser Glu 1100 1105 1110Tyr Ser Lys Val Arg Leu Asn Arg Ser Ser Ser
Ser Glu Cys Ser 1115 1120 1125Thr Val Asp Asn Pro Leu Pro Gly Glu
Gly Glu Glu Ala Glu Ala 1130 1135 1140Glu Pro Met Asn Ser Asp Glu
Pro Glu Ala Cys Phe Thr Asp Gly 1145 1150 1155Cys Val Arg Arg Phe
Ser Cys Cys Gln Val Asn Ile Glu Ser Gly 1160 1165 1170Lys Gly Lys
Ile Trp Trp Asn Ile Arg Lys Thr Cys Tyr Lys Ile 1175 1180 1185Val
Glu His Ser Trp Phe Glu Ser Phe Ile Val Leu Met Ile Leu 1190 1195
1200Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu Arg
1205 1210 1215Lys Lys Thr Ile Lys Ile Ile Leu Glu Tyr Ala Asp Lys
Ile Phe 1220 1225 1230Thr Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys
Trp Ile Ala Tyr 1235 1240 1245Gly Tyr Lys Thr Tyr Phe Thr Asn Ala
Trp Cys Trp Leu Asp Phe 1250 1255 1260Leu Ile Val Asp Val Ser Leu
Val Thr Leu Val Ala Asn Thr Leu 1265 1270 1275Gly Tyr Ser Asp Leu
Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg 1280 1285 1290Ala Leu Arg
Pro Leu Arg Ala Leu Ser Arg Phe Glu Gly Met Arg 1295 1300 1305Val
Val Val Asn Ala Leu Ile Gly Ala Ile Pro Ser Ile Met Asn 1310 1315
1320Val Leu Leu Val Cys Leu Ile Phe Trp Leu Ile Phe Ser Ile Met
1325 1330 1335Gly Val Asn Leu Phe Ala Gly Lys Phe Tyr Glu Cys Ile
Asn Thr 1340 1345 1350Thr Asp Gly Ser Arg Phe Pro Ala Ser Gln Val
Pro Asn Arg Ser 1355 1360 1365Glu Cys Phe Ala Leu Met Asn Val Ser
Gln Asn Val Arg Trp Lys 1370 1375 1380Asn Leu Lys Val Asn Phe Asp
Asn Val Gly Leu Gly Tyr Leu Ser 1385 1390 1395Leu Leu Gln Val Ala
Thr Phe Lys Gly Trp Thr Ile Ile Met Tyr 1400 1405 1410Ala Ala Val
Asp Ser Val Asn Val Asp Lys Gln Pro Lys Tyr Glu 1415 1420 1425Tyr
Ser Leu Tyr Met Tyr Ile Tyr Phe Val Val Phe Ile Ile Phe 1430 1435
1440Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp
1445 1450 1455Asn Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly Gln Asp
Ile Phe 1460 1465 1470Met Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala
Met Lys Lys Leu 1475 1480 1485Gly Ser Lys Lys Pro Gln Lys Pro Ile
Pro Arg Pro Gly Asn Lys 1490 1495 1500Ile Gln Gly Cys Ile Phe Asp
Leu Val Thr Asn Gln Ala Phe Asp 1505 1510 1515Ile Ser Ile Met Val
Leu Ile Cys Leu Asn Met Val Thr Met Met 1520 1525 1530Val Glu Lys
Glu Gly Gln Ser Gln His Met Thr Glu Val Leu Tyr 1535 1540 1545Trp
Ile Asn Val Val Phe Ile Ile Leu Phe Thr Gly Glu Cys Val 1550 1555
1560Leu Lys Leu Ile Ser Leu Arg His Tyr Tyr Phe Thr Val Gly Trp
1565 1570 1575Asn Ile Phe Asp Phe Val Val Val Ile Ile Ser Ile Val
Gly Met 1580 1585 1590Phe Leu Ala Asp Leu Ile Glu Thr Tyr Phe Val
Ser Pro Thr Leu 1595 1600 1605Phe Arg Val Ile Arg Leu Ala Arg Ile
Gly Arg Ile Leu Arg Leu 1610 1615 1620Val Lys Gly Ala Lys Gly Ile
Arg Thr Leu Leu Phe Ala Leu Met 1625 1630 1635Met Ser Leu Pro Ala
Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu 1640 1645 1650Val Met Phe
Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe Ala Tyr 1655 1660 1665Val
Lys Lys Glu Asp Gly Ile Asn Asp Met Phe Asn Phe Glu Thr 1670 1675
1680Phe Gly Asn Ser Met Ile Cys Leu Phe Gln Ile Thr Thr Ser Ala
1685 1690 1695Gly Trp Asp Gly Leu Leu Ala Pro Ile Leu Asn Ser Lys
Pro Pro 1700 1705 1710Asp Cys Asp Pro Lys Lys Val His Pro Gly Ser
Ser Val Glu Gly 1715 1720 1725Asp Cys Gly Asn Pro Ser Val Gly Ile
Phe Tyr Phe Val Ser Tyr 1730 1735 1740Ile Ile Ile Ser Phe Leu Val
Val Val Asn Met Tyr Ile Ala Val 1745 1750 1755Ile Leu Glu Asn Phe
Ser Val Ala Thr Glu Glu Ser Thr Glu Pro 1760 1765 1770Leu Ser Glu
Asp Asp Phe Glu Met Phe Tyr Glu Val Trp Glu Lys 1775 1780 1785Phe
Asp Pro Asp Ala Thr Gln Phe Ile Glu Phe Ser Lys Leu Ser 1790 1795
1800Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu Leu Ile Ala Lys Pro
1805 1810 1815Asn Lys Val Gln Leu Ile Ala Met Asp Leu Pro Met Val
Ser Gly 1820 1825 1830Asp Arg Ile His Cys Leu Asp Ile Leu Phe Ala
Phe Thr Lys Arg 1835 1840 1845Val Leu Gly Glu Ser Gly Glu Met Asp
Ser Leu Arg Ser Gln Met 1850 1855 1860Glu Glu Arg Phe Met Ser Ala
Asn Pro Ser Lys Val Ser Tyr Glu 1865 1870 1875Pro Ile Thr Thr Thr
Leu Lys Arg Lys Gln Glu Asp Val Ser Ala 1880 1885 1890Thr Val Ile
Gln Arg Ala Tyr Arg Arg Tyr Arg Leu Arg Gln Asn 1895 1900 1905Val
Lys Asn Ile Ser Ser Ile Tyr Ile Lys Asp Gly Asp Arg Asp 1910 1915
1920Asp Asp Leu Leu Asn Lys Lys Asp Met Ala Phe Asp Asn Val Asn
1925 1930 1935Glu Asn Ser Ser Pro Glu Lys Thr Asp Ala Thr Ser Ser
Thr Thr 1940 1945 1950Ser Pro Pro Ser Tyr Asp Ser Val Thr Lys Pro
Asp Lys Glu Lys 1955 1960 1965Tyr Glu Gln Asp Arg Thr Glu Lys Glu
Asp Lys Gly Lys Asp Ser 1970 1975 1980Lys Glu Ser Lys Lys
198576367DNAHomo sapiens 7ctcttatgtg aggagctgaa gaggaattaa
aatatacagg atgaaaagat ggcaatgttg 60cctcccccag gacctcagag ctttgtccat
ttcacaaaac agtctcttgc cctcattgaa 120caacgcattg ctgaaagaaa
atcaaaggaa cccaaagaag aaaagaaaga tgatgatgaa 180gaagccccaa
agccaagcag tgacttggaa gctggcaaac agctgccctt catctatggg
240gacattcctc ccggcatggt gtcagagccc ctggaggact tggaccccta
ctatgcagac 300aaaaagactt tcatagtatt gaacaaaggg aaaacaatct
tccgtttcaa tgccacacct 360gctttatata tgctttctcc tttcagtcct
ctaagaagaa tatctattaa gattttagta 420cactccttat tcagcatgct
catcatgtgc actattctga caaactgcat atttatgacc 480atgaataacc
caccggactg gaccaaaaat gtcgagtaca cttttactgg aatatatact
540tttgaatcac ttgtaaaaat ccttgcaaga ggcttctgtg taggagaatt
cacttttctt 600cgtgacccgt ggaactggct ggattttgtc gtcattgttt
ttgcgtattt aacagaattt 660gtaaacctag gcaatgtttc agctcttcga
actttcagag tattgagagc tttgaaaact 720atttctgtaa tcccaggcct
gaagacaatt gtaggggctt tgatccagtc agtgaagaag 780ctttctgatg
tcatgatcct gactgtgttc tgtctgagtg tgtttgcact aattggacta
840cagctgttca tgggaaacct gaagcataaa tgttttcgaa attcacttga
aaataatgaa 900acattagaaa gcataatgaa taccctagag agtgaagaag
actttagaaa atatttttat 960tacttggaag gatccaaaga tgctctcctt
tgtggtttca gcacagattc aggtcagtgt 1020ccagaggggt acacctgtgt
gaaaattggc agaaaccctg attatggcta cacgagcttt 1080gacactttca
gctgggcctt cttagccttg tttaggctaa tgacccaaga ttactgggaa
1140aacctttacc aacagacgct gcgtgctgct ggcaaaacct acatgatctt
ctttgtcgta 1200gtgattttcc tgggctcctt ttatctaata aacttgatcc
tggctgtggt tgccatggca 1260tatgaagaac agaaccaggc aaacattgaa
gaagctaaac agaaagaatt agaatttcaa 1320cagatgttag accgtcttaa
aaaagagcaa gaagaagctg aggcaattgc agcggcagcg 1380gctgaatata
caagtattag gagaagcaga attatgggcc tctcagagag ttcttctgaa
1440acatccaaac tgagctctaa aagtgctaaa gaaagaagaa acagaagaaa
gaaaaagaat 1500caaaagaagc tctccagtgg agaggaaaag ggagatgctg
agaaattgtc gaaatcagaa 1560tcagaggaca gcatcagaag aaaaagtttc
caccttggtg tcgaagggca taggcgagca 1620catgaaaaga ggttgtctac
ccccaatcag tcaccactca gcattcgtgg ctccttgttt 1680tctgcaaggc
gaagcagcag aacaagtctt tttagtttca aaggcagagg aagagatata
1740ggatctgaga ctgaatttgc cgatgatgag cacagcattt ttggagacaa
tgagagcaga 1800aggggctcac tgtttgtgcc ccacagaccc caggagcgac
gcagcagtaa catcagccaa 1860gccagtaggt ccccaccaat gctgccggtg
aacgggaaaa tgcacagtgc tgtggactgc 1920aacggtgtgg tctccctggt
tgatggacgc tcagccctca tgctccccaa tggacagctt 1980ctgccagagg
gcacgaccaa tcaaatacac aagaaaaggc gttgtagttc ctatctcctt
2040tcagaggata tgctgaatga tcccaacctc agacagagag caatgagtag
agcaagcata 2100ttaacaaaca ctgtggaaga acttgaagag tccagacaaa
aatgtccacc ttggtggtac 2160agatttgcac acaaattctt gatctggaat
tgctctccat attggataaa attcaaaaag 2220tgtatctatt ttattgtaat
ggatcctttt gtagatcttg caattaccat ttgcatagtt 2280ttaaacacat
tatttatggc tatggaacac cacccaatga ctgaggaatt caaaaatgta
2340cttgctatag gaaatttggt ctttactgga atctttgcag ctgaaatggt
attaaaactg 2400attgccatgg atccatatga gtatttccaa gtaggctgga
atatttttga cagccttatt 2460gtgactttaa gtttagtgga gctctttcta
gcagatgtgg aaggattgtc agttctgcga 2520tcattcagac tgctccgagt
cttcaagttg gcaaaatcct ggccaacatt gaacatgctg 2580attaagatca
ttggtaactc agtaggggct ctaggtaacc tcaccttagt gttggccatc
2640atcgtcttca tttttgctgt ggtcggcatg cagctctttg gtaagagcta
caaagaatgt 2700gtctgcaaga tcaatgatga ctgtacgctc ccacggtggc
acatgaacga cttcttccac 2760tccttcctga ttgtgttccg cgtgctgtgt
ggagagtgga tagagaccat gtgggactgt 2820atggaggtcg ctggtcaagc
tatgtgcctt attgtttaca tgatggtcat ggtcattgga 2880aacctggtgg
tcctaaacct atttctggcc ttattattga gctcatttag ttcagacaat
2940cttacagcaa ttgaagaaga ccctgatgca aacaacctcc agattgcagt
gactagaatt 3000aaaaagggaa taaattatgt gaaacaaacc ttacgtgaat
ttattctaaa agcattttcc 3060aaaaagccaa agatttccag ggagataaga
caagcagaag atctgaatac taagaaggaa 3120aactatattt ctaaccatac
acttgctgaa atgagcaaag gtcacaattt cctcaaggaa 3180aaagataaaa
tcagtggttt tggaagcagc gtggacaaac acttgatgga agacagtgat
3240ggtcaatcat ttattcacaa tcccagcctc acagtgacag tgccaattgc
acctggggaa 3300tccgatttgg aaaatatgaa tgctgaggaa cttagcagtg
attcggatag tgaatacagc 3360aaagtgagat taaaccggtc aagctcctca
gagtgcagca cagttgataa ccctttgcct 3420ggagaaggag aagaagcaga
ggctgaacct atgaattccg atgagccaga ggcctgtttc 3480acagatggtt
gtgtatggag gttctcatgc tgccaagtta acatagagtc agggaaagga
3540aaaatctggt ggaacatcag gaaaacctgc tacaagattg ttgaacacag
ttggtttgaa 3600agcttcattg tcctcatgat cctgctcagc agtggtgccc
tggcttttga agatatttat 3660attgaaagga aaaagaccat taagattatc
ctggagtatg cagacaagat cttcacttac 3720atcttcattc tggaaatgct
tctaaaatgg atagcatatg gttataaaac atatttcacc 3780aatgcctggt
gttggctgga tttcctaatt gttgatgttt ctttggttac tttagtggca
3840aacactcttg gctactcaga tcttggcccc attaaatccc ttcggacact
gagagcttta 3900agacctctaa gagccttatc tagatttgaa ggaatgaggg
tcgttgtgaa tgcactcata 3960ggagcaattc cttccatcat gaatgtgcta
cttgtgtgtc ttatattctg gctgatattc 4020agcatcatgg gagtaaattt
gtttgctggc aagttctatg agtgtattaa caccacagat 4080gggtcacggt
ttcctgcaag tcaagttcca aatcgttccg aatgttttgc ccttatgaat
4140gttagtcaaa atgtgcgatg gaaaaacctg aaagtgaact ttgataatgt
cggacttggt 4200tacctatctc tgcttcaagt tgcaactttt aagggatgga
cgattattat gtatgcagca 4260gtggattctg ttaatgtaga caagcagccc
aaatatgaat atagcctcta catgtatatt 4320tattttgtcg tctttatcat
ctttgggtca ttcttcactt
tgaacttgtt cattggtgtc 4380atcatagata atttcaacca acagaaaaag
aagcttggag gtcaagacat ctttatgaca 4440gaagaacaga agaaatacta
taatgcaatg aaaaagctgg ggtccaagaa gccacaaaag 4500ccaattcctc
gaccagggaa caaaatccaa ggatgtatat ttgacctagt gacaaatcaa
4560gcctttgata ttagtatcat ggttcttatc tgtctcaaca tggtaaccat
gatggtagaa 4620aaggagggtc aaagtcaaca tatgactgaa gttttatatt
ggataaatgt ggtttttata 4680atccttttca ctggagaatg tgtgctaaaa
ctgatctccc tcagacacta ctacttcact 4740gtaggatgga atatttttga
ttttgtggtt gtgattatct ccattgtagg tatgtttcta 4800gctgatttga
ttgaaacgta ttttgtgtcc cctaccctgt tccgagtgat ccgtcttgcc
4860aggattggcc gaatcctacg tctagtcaaa ggagcaaagg ggatccgcac
gctgctcttt 4920gctttgatga tgtcccttcc tgcgttgttt aacatcggcc
tcctgctctt cctggtcatg 4980ttcatctacg ccatctttgg aatgtccaac
tttgcctatg ttaaaaagga agatggaatt 5040aatgacatgt tcaattttga
gacctttggc aacagtatga tttgcctgtt ccaaattaca 5100acctctgctg
gctgagatgg attgctagca cctattctta acagtaagcc acccgactgt
5160gacccaaaaa aagttcatcc tggaagttca gttgaaggag actgtggtaa
cccatctgtt 5220ggaatattct actttgttag ttatatcatc atatccttcc
tggttgtggt gaacatgtac 5280attgcagtca tactggagaa ttttagtgtt
gccactgaag aaagtactga acctctgagt 5340gaggatgact ttgagatgtt
ctatgaggtt tgggagaagt ttgatcccga tgcgacccag 5400tttatagagt
tctctaaact ctctgatttt gcagctgccc tggatcctcc tcttctcata
5460gcaaaaccca acaaagtcca gctcattgcc atggatctgc ccatggttag
tggtgaccgg 5520atccattgtc ttgacatctt atttgctttt acaaagcgtg
ttttgggtga gagtggggag 5580atggattctc ttcgttcaca gatggaagaa
aggttcatgt ctgcaaatcc ttccaaagtg 5640tcctatgaac ccatcacaac
cacactaaaa cggaaacaag aggatgtgtc tgctactgtc 5700attcagcgtg
cttatagacg ttaccgctta aggcaaaatg tcaaaaatat atcaagtata
5760tacataaaag atggagacag agatgatgat ttactcaata aaaaagatat
ggcttttgat 5820aatgttaatg agaactcaag tccagaaaaa acagatgcca
cttcatccac cacctctcca 5880ccttcatatg atagtgtaac aaagccagac
aaagagaaat atgaacaaga cagaacagaa 5940aaggaagaca aagggaaaga
cagcaaggaa agcaaaaaat agagcttcat ttttgatata 6000ttgtttacag
cctgtgaaag tgatttattt gtgttaataa aactcttttg aggaagtcta
6060tgccaaaatc ctttttatca aaatattctc gaaggcagtg cagtcactaa
ctctgatttc 6120ctaagaaagg tgggcagcat tagcagatgg ttatttttgc
actgatgatt ctttaagaat 6180cgtaagagaa ctctgtagga attattgatt
atagcataca aaagtgattc agttttttgg 6240tttttaataa atcagaagac
catgtagaaa acttttacat ctgccttgtc atcttttcac 6300aggattgtaa
ttagtcttgt ttcccatgta aataaacaac acacgcatac agaaaaaaaa 6360aaaaaaa
636781688PRTHomo sapiens 8Met Ala Met Leu Pro Pro Pro Gly Pro Gln
Ser Phe Val His Phe Thr1 5 10 15Lys Gln Ser Leu Ala Leu Ile Glu Gln
Arg Ile Ala Glu Arg Lys Ser 20 25 30Lys Glu Pro Lys Glu Glu Lys Lys
Asp Asp Asp Glu Glu Ala Pro Lys 35 40 45Pro Ser Ser Asp Leu Glu Ala
Gly Lys Gln Leu Pro Phe Ile Tyr Gly 50 55 60Asp Ile Pro Pro Gly Met
Val Ser Glu Pro Leu Glu Asp Leu Asp Pro65 70 75 80Tyr Tyr Ala Asp
Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 85 90 95Ile Phe Arg
Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 100 105 110Ser
Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 115 120
125Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr
130 135 140Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr
Phe Thr145 150 155 160Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile
Leu Ala Arg Gly Phe 165 170 175Cys Val Gly Glu Phe Thr Phe Leu Arg
Asp Pro Trp Asn Trp Leu Asp 180 185 190Phe Val Val Ile Val Phe Ala
Tyr Leu Thr Glu Phe Val Asn Leu Gly 195 200 205Asn Val Ser Ala Leu
Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 210 215 220Ile Ser Val
Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln225 230 235
240Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu
245 250 255Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn
Leu Lys 260 265 270His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu
Thr Leu Glu Ser 275 280 285Ile Met Asn Thr Leu Glu Ser Glu Glu Asp
Phe Arg Lys Tyr Phe Tyr 290 295 300Tyr Leu Glu Gly Ser Lys Asp Ala
Leu Leu Cys Gly Phe Ser Thr Asp305 310 315 320Ser Gly Gln Cys Pro
Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 325 330 335Pro Asp Tyr
Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 340 345 350Ala
Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 355 360
365Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val
370 375 380Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu
Ala Val385 390 395 400Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala
Asn Ile Glu Glu Ala 405 410 415Lys Gln Lys Glu Leu Glu Phe Gln Gln
Met Leu Asp Arg Leu Lys Lys 420 425 430Glu Gln Glu Glu Ala Glu Ala
Ile Ala Ala Ala Ala Ala Glu Tyr Thr 435 440 445Ser Ile Arg Arg Ser
Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 450 455 460Thr Ser Lys
Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg465 470 475
480Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp
485 490 495Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg
Arg Lys 500 505 510Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala
His Glu Lys Arg 515 520 525Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser
Ile Arg Gly Ser Leu Phe 530 535 540Ser Ala Arg Arg Ser Ser Arg Thr
Ser Leu Phe Ser Phe Lys Gly Arg545 550 555 560Gly Arg Asp Ile Gly
Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 565 570 575Ile Phe Gly
Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 580 585 590Arg
Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 595 600
605Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys
610 615 620Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met
Leu Pro625 630 635 640Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn
Gln Ile His Lys Lys 645 650 655Arg Arg Cys Ser Ser Tyr Leu Leu Ser
Glu Asp Met Leu Asn Asp Pro 660 665 670Asn Leu Arg Gln Arg Ala Met
Ser Arg Ala Ser Ile Leu Thr Asn Thr 675 680 685Val Glu Glu Leu Glu
Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 690 695 700Arg Phe Ala
His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile705 710 715
720Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp
725 730 735Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met
Ala Met 740 745 750Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val
Leu Ala Ile Gly 755 760 765Asn Leu Val Phe Thr Gly Ile Phe Ala Ala
Glu Met Val Leu Lys Leu 770 775 780Ile Ala Met Asp Pro Tyr Glu Tyr
Phe Gln Val Gly Trp Asn Ile Phe785 790 795 800Asp Ser Leu Ile Val
Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 805 810 815Val Glu Gly
Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 820 825 830Lys
Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 835 840
845Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile
850 855 860Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly
Lys Ser865 870 875 880Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp
Cys Thr Leu Pro Arg 885 890 895Trp His Met Asn Asp Phe Phe His Ser
Phe Leu Ile Val Phe Arg Val 900 905 910Leu Cys Gly Glu Trp Ile Glu
Thr Met Trp Asp Cys Met Glu Val Ala 915 920 925Gly Gln Ala Met Cys
Leu Ile Val Tyr Met Met Val Met Val Ile Gly 930 935 940Asn Leu Val
Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe945 950 955
960Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn
965 970 975Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr
Val Lys 980 985 990Gln Thr Leu Arg Glu Phe Ile Leu Lys Ala Phe Ser
Lys Lys Pro Lys 995 1000 1005Ile Ser Arg Glu Ile Arg Gln Ala Glu
Asp Leu Asn Thr Lys Lys 1010 1015 1020Glu Asn Tyr Ile Ser Asn His
Thr Leu Ala Glu Met Ser Lys Gly 1025 1030 1035His Asn Phe Leu Lys
Glu Lys Asp Lys Ile Ser Gly Phe Gly Ser 1040 1045 1050Ser Val Asp
Lys His Leu Met Glu Asp Ser Asp Gly Gln Ser Phe 1055 1060 1065Ile
His Asn Pro Ser Leu Thr Val Thr Val Pro Ile Ala Pro Gly 1070 1075
1080Glu Ser Asp Leu Glu Asn Met Asn Ala Glu Glu Leu Ser Ser Asp
1085 1090 1095Ser Asp Ser Glu Tyr Ser Lys Val Arg Leu Asn Arg Ser
Ser Ser 1100 1105 1110Ser Glu Cys Ser Thr Val Asp Asn Pro Leu Pro
Gly Glu Gly Glu 1115 1120 1125Glu Ala Glu Ala Glu Pro Met Asn Ser
Asp Glu Pro Glu Ala Cys 1130 1135 1140Phe Thr Asp Gly Cys Val Trp
Arg Phe Ser Cys Cys Gln Val Asn 1145 1150 1155Ile Glu Ser Gly Lys
Gly Lys Ile Trp Trp Asn Ile Arg Lys Thr 1160 1165 1170Cys Tyr Lys
Ile Val Glu His Ser Trp Phe Glu Ser Phe Ile Val 1175 1180 1185Leu
Met Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile 1190 1195
1200Tyr Ile Glu Arg Lys Lys Thr Ile Lys Ile Ile Leu Glu Tyr Ala
1205 1210 1215Asp Lys Ile Phe Thr Tyr Ile Phe Ile Leu Glu Met Leu
Leu Lys 1220 1225 1230Trp Ile Ala Tyr Gly Tyr Lys Thr Tyr Phe Thr
Asn Ala Trp Cys 1235 1240 1245Trp Leu Asp Phe Leu Ile Val Asp Val
Ser Leu Val Thr Leu Val 1250 1255 1260Ala Asn Thr Leu Gly Tyr Ser
Asp Leu Gly Pro Ile Lys Ser Leu 1265 1270 1275Arg Thr Leu Arg Ala
Leu Arg Pro Leu Arg Ala Leu Ser Arg Phe 1280 1285 1290Glu Gly Met
Arg Val Val Val Asn Ala Leu Ile Gly Ala Ile Pro 1295 1300 1305Ser
Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe Trp Leu Ile 1310 1315
1320Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe Tyr Glu
1325 1330 1335Cys Ile Asn Thr Thr Asp Gly Ser Arg Phe Pro Ala Ser
Gln Val 1340 1345 1350Pro Asn Arg Ser Glu Cys Phe Ala Leu Met Asn
Val Ser Gln Asn 1355 1360 1365Val Arg Trp Lys Asn Leu Lys Val Asn
Phe Asp Asn Val Gly Leu 1370 1375 1380Gly Tyr Leu Ser Leu Leu Gln
Val Ala Thr Phe Lys Gly Trp Thr 1385 1390 1395Ile Ile Met Tyr Ala
Ala Val Asp Ser Val Asn Val Asp Lys Gln 1400 1405 1410Pro Lys Tyr
Glu Tyr Ser Leu Tyr Met Tyr Ile Tyr Phe Val Val 1415 1420 1425Phe
Ile Ile Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly 1430 1435
1440Val Ile Ile Asp Asn Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly
1445 1450 1455Gln Asp Ile Phe Met Thr Glu Glu Gln Lys Lys Tyr Tyr
Asn Ala 1460 1465 1470Met Lys Lys Leu Gly Ser Lys Lys Pro Gln Lys
Pro Ile Pro Arg 1475 1480 1485Pro Gly Asn Lys Ile Gln Gly Cys Ile
Phe Asp Leu Val Thr Asn 1490 1495 1500Gln Ala Phe Asp Ile Ser Ile
Met Val Leu Ile Cys Leu Asn Met 1505 1510 1515Val Thr Met Met Val
Glu Lys Glu Gly Gln Ser Gln His Met Thr 1520 1525 1530Glu Val Leu
Tyr Trp Ile Asn Val Val Phe Ile Ile Leu Phe Thr 1535 1540 1545Gly
Glu Cys Val Leu Lys Leu Ile Ser Leu Arg His Tyr Tyr Phe 1550 1555
1560Thr Val Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile Ile Ser
1565 1570 1575Ile Val Gly Met Phe Leu Ala Asp Leu Ile Glu Thr Tyr
Phe Val 1580 1585 1590Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala
Arg Ile Gly Arg 1595 1600 1605Ile Leu Arg Leu Val Lys Gly Ala Lys
Gly Ile Arg Thr Leu Leu 1610 1615 1620Phe Ala Leu Met Met Ser Leu
Pro Ala Leu Phe Asn Ile Gly Leu 1625 1630 1635Leu Leu Phe Leu Val
Met Phe Ile Tyr Ala Ile Phe Gly Met Ser 1640 1645 1650Asn Phe Ala
Tyr Val Lys Lys Glu Asp Gly Ile Asn Asp Met Phe 1655 1660 1665Asn
Phe Glu Thr Phe Gly Asn Ser Met Ile Cys Leu Phe Gln Ile 1670 1675
1680Thr Thr Ser Ala Gly 168596367DNAHomo sapiens 9ctcttatgtg
aggagctgaa gaggaattaa aatatacagg atgaaaagat ggcaatgttg 60cctcccccag
gacctcagag ctttgtccat ttcacaaaac agtctcttgc cctcattgaa
120caacgcattg ctgaaagaaa atcaaaggaa cccaaagaag aaaagaaaga
tgatgatgaa 180gaagccccaa agccaagcag tgacttggaa gctggcaaac
agctgccctt catctatggg 240gacattcctc ccggcatggt gtcagagccc
ctggaggact tggaccccta ctatgcagac 300aaaaagactt tcatagtatt
gaacaaaggg aaaacaatct tccgtttcaa tgccacacct 360gctttatata
tgctttctcc tttcagtcct ctaagaagaa tatctattaa gattttagta
420cactccttat tcagcatgct catcatgtgc actattctga caaactgcat
atttatgacc 480atgaataacc caccggactg gaccaaaaat gtcgagtaca
cttttactgg aatatatact 540tttgaatcac ttgtaaaaat ccttgcaaga
ggcttctgtg taggagaatt cacttttctt 600cgtgacccgt ggaactggct
ggattttgtc gtcattgttt ttgcgtattt aacagaattt 660gtaaacctag
gcaatgtttc agctcttcga actttcagag tattgagagc tttgaaaact
720atttctgtaa tcccaggcct gaagacaatt gtaggggctt tgatccagtc
agtgaagaag 780ctttctgatg tcatgatcct gactgtgttc tgtctgagtg
tgtttgcact aattggacta 840cagctgttca tgggaaacct gaagcataaa
tgttttcgaa attcacttga aaataatgaa 900acattagaaa gcataatgaa
taccctagag agtgaagaag actttagaaa atatttttat 960tacttggaag
gatccaaaga tgctctcctt tgtggtttca gcacagattc aggtcagtgt
1020ccagaggggt aaacctgtgt gaaaattggc agaaaccctg attatggcta
cacgagcttt 1080gacactttca gctgggcctt cttagccttg tttaggctaa
tgacccaaga ttactgggaa 1140aacctttacc aacagacgct gcgtgctgct
ggcaaaacct acatgatctt ctttgtcgta 1200gtgattttcc tgggctcctt
ttatctaata aacttgatcc tggctgtggt tgccatggca 1260tatgaagaac
agaaccaggc aaacattgaa gaagctaaac agaaagaatt agaatttcaa
1320cagatgttag accgtcttaa aaaagagcaa gaagaagctg aggcaattgc
agcggcagcg 1380gctgaatata caagtattag gagaagcaga attatgggcc
tctcagagag ttcttctgaa 1440acatccaaac tgagctctaa aagtgctaaa
gaaagaagaa acagaagaaa gaaaaagaat 1500caaaagaagc tctccagtgg
agaggaaaag ggagatgctg agaaattgtc gaaatcagaa 1560tcagaggaca
gcatcagaag aaaaagtttc caccttggtg tcgaagggca taggcgagca
1620catgaaaaga ggttgtctac ccccaatcag tcaccactca gcattcgtgg
ctccttgttt 1680tctgcaaggc gaagcagcag aacaagtctt tttagtttca
aaggcagagg aagagatata 1740ggatctgaga ctgaatttgc cgatgatgag
cacagcattt ttggagacaa tgagagcaga 1800aggggctcac tgtttgtgcc
ccacagaccc caggagcgac gcagcagtaa catcagccaa 1860gccagtaggt
ccccaccaat gctgccggtg aacgggaaaa tgcacagtgc tgtggactgc
1920aacggtgtgg tctccctggt tgatggacgc tcagccctca tgctccccaa
tggacagctt 1980ctgccagagg gcacgaccaa tcaaatacac aagaaaaggc
gttgtagttc ctatctcctt 2040tcagaggata tgctgaatga tcccaacctc
agacagagag caatgagtag agcaagcata 2100ttaacaaaca ctgtggaaga
acttgaagag tccagacaaa aatgtccacc ttggtggtac 2160agatttgcac
acaaattctt gatctggaat tgctctccat attggataaa attcaaaaag
2220tgtatctatt ttattgtaat ggatcctttt gtagatcttg caattaccat
ttgcatagtt 2280ttaaacacat tatttatggc tatggaacac cacccaatga
ctgaggaatt caaaaatgta 2340cttgctatag gaaatttggt ctttactgga
atctttgcag ctgaaatggt attaaaactg 2400attgccatgg atccatatga
gtatttccaa gtaggctgga atatttttga cagccttatt 2460gtgactttaa
gtttagtgga gctctttcta gcagatgtgg aaggattgtc agttctgcga
2520tcattcagac tgctccgagt cttcaagttg gcaaaatcct ggccaacatt
gaacatgctg 2580attaagatca ttggtaactc agtaggggct ctaggtaacc
tcaccttagt gttggccatc 2640atcgtcttca tttttgctgt ggtcggcatg
cagctctttg gtaagagcta caaagaatgt 2700gtctgcaaga tcaatgatga
ctgtacgctc ccacggtggc acatgaacga cttcttccac 2760tccttcctga
ttgtgttccg cgtgctgtgt ggagagtgga tagagaccat gtgggactgt
2820atggaggtcg ctggtcaagc tatgtgcctt attgtttaca tgatggtcat
ggtcattgga 2880aacctggtgg tcctaaacct atttctggcc ttattattga
gctcatttag ttcagacaat 2940cttacagcaa ttgaagaaga ccctgatgca
aacaacctcc agattgcagt gactagaatt 3000aaaaagggaa taaattatgt
gaaacaaacc ttacgtgaat ttattctaaa agcattttcc 3060aaaaagccaa
agatttccag ggagataaga caagcagaag atctgaatac taagaaggaa
3120aactatattt ctaaccatac acttgctgaa atgagcaaag gtcacaattt
cctcaaggaa 3180aaagataaaa tcagtggttt tggaagcagc gtggacaaac
acttgatgga agacagtgat 3240ggtcaatcat ttattcacaa tcccagcctc
acagtgacag tgccaattgc acctggggaa 3300tccgatttgg aaaatatgaa
tgctgaggaa cttagcagtg attcggatag tgaatacagc 3360aaagtgagat
taaaccggtc aagctcctca gagtgcagca cagttgataa ccctttgcct
3420ggagaaggag aagaagcaga ggctgaacct atgaattccg atgagccaga
ggcctgtttc 3480acagatggtt gtgtatggag gttctcatgc tgccaagtta
acatagagtc agggaaagga 3540aaaatctggt ggaacatcag gaaaacctgc
tacaagattg ttgaacacag ttggtttgaa 3600agcttcattg tcctcatgat
cctgctcagc agtggtgccc tggcttttga agatatttat 3660attgaaagga
aaaagaccat taagattatc ctggagtatg cagacaagat cttcacttac
3720atcttcattc tggaaatgct tctaaaatgg atagcatatg gttataaaac
atatttcacc 3780aatgcctggt gttggctgga tttcctaatt gttgatgttt
ctttggttac tttagtggca 3840aacactcttg gctactcaga tcttggcccc
attaaatccc ttcggacact gagagcttta 3900agacctctaa gagccttatc
tagatttgaa ggaatgaggg tcgttgtgaa tgcactcata 3960ggagcaattc
cttccatcat gaatgtgcta cttgtgtgtc ttatattctg gctgatattc
4020agcatcatgg gagtaaattt gtttgctggc aagttctatg agtgtattaa
caccacagat 4080gggtcacggt ttcctgcaag tcaagttcca aatcgttccg
aatgttttgc ccttatgaat 4140gttagtcaaa atgtgcgatg gaaaaacctg
aaagtgaact ttgataatgt cggacttggt 4200tacctatctc tgcttcaagt
tgcaactttt aagggatgga cgattattat gtatgcagca 4260gtggattctg
ttaatgtaga caagcagccc aaatatgaat atagcctcta catgtatatt
4320tattttgtcg tctttatcat ctttgggtca ttcttcactt tgaacttgtt
cattggtgtc 4380atcatagata atttcaacca acagaaaaag aagcttggag
gtcaagacat ctttatgaca 4440gaagaacaga agaaatacta taatgcaatg
aaaaagctgg ggtccaagaa gccacaaaag 4500ccaattcctc gaccagggaa
caaaatccaa ggatgtatat ttgacctagt gacaaatcaa 4560gcctttgata
ttagtatcat ggttcttatc tgtctcaaca tggtaaccat gatggtagaa
4620aaggagggtc aaagtcaaca tatgactgaa gttttatatt ggataaatgt
ggtttttata 4680atccttttca ctggagaatg tgtgctaaaa ctgatctccc
tcagacacta ctacttcact 4740gtaggatgga atatttttga ttttgtggtt
gtgattatct ccattgtagg tatgtttcta 4800gctgatttga ttgaaacgta
ttttgtgtcc cctaccctgt tccgagtgat ccgtcttgcc 4860aggattggcc
gaatcctacg tctagtcaaa ggagcaaagg ggatccgcac gctgctcttt
4920gctttgatga tgtcccttcc tgcgttgttt aacatcggcc tcctgctctt
cctggtcatg 4980ttcatctacg ccatctttgg aatgtccaac tttgcctatg
ttaaaaagga agatggaatt 5040aatgacatgt tcaattttga gacctttggc
aacagtatga tttgcctgtt ccaaattaca 5100acctctgctg gctgggatgg
attgctagca cctattctta acagtaagcc acccgactgt 5160gacccaaaaa
aagttcatcc tggaagttca gttgaaggag actgtggtaa cccatctgtt
5220ggaatattct actttgttag ttatatcatc atatccttcc tggttgtggt
gaacatgtac 5280attgcagtca tactggagaa ttttagtgtt gccactgaag
aaagtactga acctctgagt 5340gaggatgact ttgagatgtt ctatgaggtt
tgggagaagt ttgatcccga tgcgacccag 5400tttatagagt tctctaaact
ctctgatttt gcagctgccc tggatcctcc tcttctcata 5460gcaaaaccca
acaaagtcca gctcattgcc atggatctgc ccatggttag tggtgaccgg
5520atccattgtc ttgacatctt atttgctttt acaaagcgtg ttttgggtga
gagtggggag 5580atggattctc ttcgttcaca gatggaagaa aggttcatgt
ctgcaaatcc ttccaaagtg 5640tcctatgaac ccatcacaac cacactaaaa
cggaaacaag aggatgtgtc tgctactgtc 5700attcagcgtg cttatagacg
ttaccgctta aggcaaaatg tcaaaaatat atcaagtata 5760tacataaaag
atggagacag agatgatgat ttactcaata aaaaagatat ggcttttgat
5820aatgttaatg agaactcaag tccagaaaaa acagatgcca cttcatccac
cacctctcca 5880ccttcatatg atagtgtaac aaagccagac aaagagaaat
atgaacaaga cagaacagaa 5940aaggaagaca aagggaaaga cagcaaggaa
agcaaaaaat agagcttcat ttttgatata 6000ttgtttacag cctgtgaaag
tgatttattt gtgttaataa aactcttttg aggaagtcta 6060tgccaaaatc
ctttttatca aaatattctc gaaggcagtg cagtcactaa ctctgatttc
6120ctaagaaagg tgggcagcat tagcagatgg ttatttttgc actgatgatt
ctttaagaat 6180cgtaagagaa ctctgtagga attattgatt atagcataca
aaagtgattc agttttttgg 6240tttttaataa atcagaagac catgtagaaa
acttttacat ctgccttgtc atcttttcac 6300aggattgtaa ttagtcttgt
ttcccatgta aataaacaac acacgcatac agaaaaaaaa 6360aaaaaaa
636710327PRTHomo sapiens 10Met Ala Met Leu Pro Pro Pro Gly Pro Gln
Ser Phe Val His Phe Thr1 5 10 15Lys Gln Ser Leu Ala Leu Ile Glu Gln
Arg Ile Ala Glu Arg Lys Ser 20 25 30Lys Glu Pro Lys Glu Glu Lys Lys
Asp Asp Asp Glu Glu Ala Pro Lys 35 40 45Pro Ser Ser Asp Leu Glu Ala
Gly Lys Gln Leu Pro Phe Ile Tyr Gly 50 55 60Asp Ile Pro Pro Gly Met
Val Ser Glu Pro Leu Glu Asp Leu Asp Pro65 70 75 80Tyr Tyr Ala Asp
Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 85 90 95Ile Phe Arg
Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 100 105 110Ser
Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 115 120
125Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr
130 135 140Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr
Phe Thr145 150 155 160Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile
Leu Ala Arg Gly Phe 165 170 175Cys Val Gly Glu Phe Thr Phe Leu Arg
Asp Pro Trp Asn Trp Leu Asp 180 185 190Phe Val Val Ile Val Phe Ala
Tyr Leu Thr Glu Phe Val Asn Leu Gly 195 200 205Asn Val Ser Ala Leu
Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 210 215 220Ile Ser Val
Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln225 230 235
240Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu
245 250 255Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn
Leu Lys 260 265 270His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu
Thr Leu Glu Ser 275 280 285Ile Met Asn Thr Leu Glu Ser Glu Glu Asp
Phe Arg Lys Tyr Phe Tyr 290 295 300Tyr Leu Glu Gly Ser Lys Asp Ala
Leu Leu Cys Gly Phe Ser Thr Asp305 310 315 320Ser Gly Gln Cys Pro
Glu Gly 325116367DNAHomo sapiens 11ctcttatgtg aggagctgaa gaggaattaa
aatatacagg atgaaaagat ggcaatgttg 60cctcccccag gacctcagag ctttgtccat
ttcacaaaac agtctcttgc cctcattgaa 120caacgcattg ctgaaagaaa
atcaaaggaa cccaaagaag aaaagaaaga tgatgatgaa 180gaagccccaa
agccaagcag tgacttggaa gctggcaaac aactgccctt catctatggg
240gacattcctc ccggcatggt gtcagagccc ctggaggact tggaccccta
ctatgcagac 300aaaaagactt tcatagtatt gaacaaaggg aaaacaatct
tccgtttcaa tgccacacct 360gctttatata tgctttctcc tttcagtcct
ctaagaagaa tatctattaa gattttagta 420cactccttat tcagcatgct
catcatgtgc actattctga caaactgcat atttatgacc 480atgaataacc
cgccggactg gaccaaaaat gtcgagtaca cttttactgg aatatatact
540tttgaatcac ttgtaaaaat ccttgcaaga ggcttctgtg taggagaatt
cacttttctt 600cgtgacccgt ggaactggct ggattttgtc gtcattgttt
ttgcgtattt aacagaattt 660gtaaacctag gcaatgtttc agctcttcga
actttcagag tattgagagc tttgaaaact 720atttctgtaa tcccaggcct
gaagacaatt gtaggggctt tgatccagtc agtgaagaag 780ctttctgatg
tcatgatcct gactgtgttc tgtctgagtg tgtttgcact aattggacta
840cagctgttca tgggaaacct gaagcataaa tgttttcgaa attcacttga
aaataatgaa 900acattagaaa gcataatgaa taccctagag agtgaagaag
actttagaaa atatttttat 960tacttggaag gatccaaaga tgctctcctt
tgtggtttca gcacagattc aggtcagtgt 1020ccagaggggt acacctgtgt
gaaaattggc agaaaccctg attatggcta cacgagcttt 1080gacactttca
gctgggcctt cttagccttg tttaggctaa tgacccaaga ttactgggaa
1140aacctttacc aacagacgct gcgtgccgct ggcaaaacct acatgatctt
ctttgtcgta 1200gtgattttcc tgggctcctt ttatctaata aacttgatcc
tggctgtggt tgccatggca 1260tatgaagaac agaaccaggc aaacattgaa
gaagctaaac agaaagaatt agagtttcaa 1320cagatgttag accgacttaa
aaaagagcaa gaagaagctg aggcaattgc agcggcagcg 1380gctgaatata
caagtattag gagaagcaga attatgggcc tctcagagag ttcttctgaa
1440acatccaaac tgagctctaa aagtgctaaa gaaagaagaa acagaagaaa
gaaaaagaat 1500caaaagaagc tctccagtgg agaggaaaag ggagatgctg
agaaattgtc gaaatcagaa 1560tcagaggaca gcatcagaag aaaaagtttc
caccttggtg tcgaagggca taggcgagca 1620catgaaaaga ggttgtctac
ccccaatcag tcaccactca gcattcgtgg ctccttgttt 1680tctgcaaggc
gaagcagcag aacaagtctt tttagtttca aaggcagagg aagagatata
1740ggatctgaga ctgaatttgc cgatgatgag cacagcattt ttggagacaa
tgagagcaga 1800aggggctcac tgtttgtgcc ccacagaccc caggagcgac
gcagcagtaa catcagccaa 1860gccagtaggt ccccaccaat gctgccggtg
aacgggaaaa tgcacagtgc tgtggactgc 1920aacggtgtgg tctccctggt
tgatggacgc tcagccctca tgctccccaa tggacagctt 1980ctgccagagg
gcacgaccaa tcaaatacac aagaaaaggc gttgtagttc ctatctcctt
2040tcagaggata tgctgaatga tcccaacctc agacagagag caatgagtag
agcaagcata 2100ttaacaaaca ctgtggaaga acttgaagag tccagacaaa
aatgtccacc ttggtggtac 2160agatttgcac acaaattctt gatctggaat
tgctctccat attggataaa attcaaaaag 2220tgtatctatt ttattgtaat
ggatcctttt gtagatcttg caattaccat ttgcatagtt 2280ttaaacacat
tatttatggc tatggaacac cacccaatga ctgaggaatt caaaaatgta
2340cttgctatag gaaatttggt ctttactgga atctttgcag ctgaaatggt
attaaaactg 2400attgccatgg atccatatga gtatttccaa gtaggctgga
atatttttga cagccttatt 2460gtgactttaa gtttagtgga gctctttcta
gcagatgtgg aaggattgtc agttctgcga 2520tcattcagac tgctctgagt
cttcaagttg gcaaaatcct ggccaacatt gaacatgctg 2580attaagatca
ttggtaactc agtaggggct ctaggtaacc tcaccttagt gttggccatc
2640atcgtcttca tttttgctgt ggtcggcatg cagctctttg gtaagagcta
caaagaatgt 2700gtctgcaaga tcaatgatga ctgtacgctc ccacggtggc
acatgaacga cttcttccac 2760tccttcctga ttgtgttccg cgtgctgtgt
ggagagtgga tagagaccat gtgggactgt 2820atggaggtcg ctggtcaagc
tatgtgcctt attgtttaca tgatggtcat ggtcattgga 2880aacctggtgg
tcctaaacct atttctggcc ttattattga gctcatttag ttcagacaat
2940cttacagcaa ttgaagaaga ccctgatgca aacaacctcc agattgcagt
gactagaatt 3000aaaaagggaa taaattatgt gaaacaaacc ttacgtgaat
ttattctaaa agcattttcc 3060aaaaagccaa agatttccag ggagataaga
caagcagaag atctgaatac taagaaggaa 3120aactatattt ctaaccatac
acttgctgaa atgagcaaag gtcacaattt cctcaaggaa 3180aaagataaaa
tcagtggttt tggaagcagc gtggacaaac acttgatgga agacagtgat
3240ggtcaatcat ttattcacaa tcccagcctc acagtgacag tgccaattgc
acctggggaa 3300tccgatttgg aaaatatgaa tgctgaggaa cttagcagtg
attcggatag tgaatacagc 3360aaagtgagat taaaccggtc aagctcctca
gagtgcagca cagttgataa ccctttgcct 3420ggagaaggag aagaagcaga
ggctgaacct atgaattccg atgagccaga ggcctgtttc 3480acagatggtt
gtgtacggag gttctcatgc tgccaagtta acatagagtc agggaaagga
3540aaaatctggt ggaacatcag gaaaacctgc tacaagattg ttgaacacag
ttggtttgaa 3600agcttcattg tcctcatgat cctgctcagc agtggtgccc
tggcttttga agatatttat 3660attgaaagga aaaagaccat taagattatc
ctggagtatg cagacaagat cttcacttac 3720atcttcattc tggaaatgct
tctaaaatgg atagcatatg gttataaaac atatttcacc 3780aatgcctggt
gttggctgga tttcctaatt gttgatgttt ctttggttac tttagtggca
3840aacactcttg gctactcaga tcttggcccc attaaatccc ttcggacact
gagagcttta 3900agacctctaa gagccttatc tagatttgaa ggaatgaggg
tcgttgtgaa tgcactcata 3960ggagcaattc cttccatcat gaatgtgcta
cttgtgtgtc ttatattctg gctgatattc 4020agcatcatgg gagtaaattt
gtttgctggc aagttctatg agtgtattaa caccacagat 4080gggtcacggt
ttcctgcaag tcaagttcca aatcgttccg aatgttttgc ccttatgaat
4140gttagtcaaa atgtgcgatg gaaaaacctg aaagtgaact ttgataatgt
cggacttggt 4200tacctatctc tgcttcaagt tgcaactttt aagggatgga
cgattattat gtatgcagca 4260gtggattctg ttaatgtaga caagcagccc
aaatatgaat atagcctcta catgtatatt 4320tattttgtcg tctttatcat
ctttgggtca ttcttcactt tgaacttgtt cattggtgtc 4380atcatagata
atttcaacca acagaaaaag aagcttggag gtcaagacat ctttatgaca
4440gaagaacaga agaaatacta taatgcaatg aaaaagctgg ggtccaagaa
gccacaaaag 4500ccaattcctc gaccagggaa caaaatccaa ggatgtatat
ttgacctagt gacaaatcaa 4560gcctttgata ttagtatcat ggttcttatc
tgtctcaaca tggtaaccat gatggtagaa 4620aaggagggtc aaagtcaaca
tatgactgaa gttttatatt ggataaatgt ggtttttata 4680atccttttca
ctggagaatg tgtgctaaaa ctgatctccc tcagacacta ctacttcact
4740gtaggatgga atatttttga ttttgtggtt gtgattatct ccattgtagg
tatgtttcta 4800gctgatttga ttgaaacgta ttttgtgtcc cctaccctgt
tccgagtgat ccgtcttgcc 4860aggattggcc gaatcctacg tctagtcaaa
ggagcaaagg ggatccgcac gctgctcttt 4920gctttgatga tgtcccttcc
tgcgttgttt aacatcggcc tcctgctctt cctggtcatg 4980ttcatctacg
ccatctttgg aatgtccaac tttgcctatg ttaaaaagga agatggaatt
5040aatgacatgt tcaattttga gacctttggc aacagtatga tttgcctgtt
ccaaattaca 5100acctctgctg gctgggatgg attgctagca cctattctta
acagtaagcc acccgactgt 5160gacccaaaaa aagttcatcc tggaagttca
gttgaaggag actgtggtaa cccatctgtt 5220ggaatattct actttgttag
ttatatcatc atatccttcc tggttgtggt gaacatgtac 5280attgcagtca
tactggagaa ttttagtgtt gccactgaag aaagtactga acctctgagt
5340gaggatgact ttgagatgtt ctatgaggtt tgggagaagt ttgatcccga
tgcgacccag 5400tttatagagt tctctaaact ctctgatttt gcagctgccc
tggatcctcc tcttctcata 5460gcaaaaccca acaaagtcca gctcattgcc
atggatctgc ccatggttag tggtgaccgg 5520atccattgtc ttgacatctt
atttgctttt acaaagcgtg ttttgggtga gagtggggag 5580atggattctc
ttcgttcaca gatggaagaa aggttcatgt ctgcaaatcc ttccaaagtg
5640tcctatgaac ccatcacaac cacactaaaa cggaaacaag aggatgtgtc
tgctactgtc 5700attcagcgtg cttatagacg ttaccgctta aggcaaaatg
tcaaaaatat atcaagtata 5760tacataaaag atggagacag agatgatgat
ttactcaata aaaaagatat ggcttttgat 5820aatgttaatg agaactcaag
tccagaaaaa acagatgcca cttcatccac cacctctcca 5880ccttcatatg
atagtgtaac aaagccagac aaagagaaat atgaacaaga cagaacagaa
5940aaggaagaca aagggaaaga cagcaaggaa agcaaaaaat agagcttcat
ttttgatata 6000ttgtttacag cctgtgaaag tgatttattt gtgttaataa
aactcttttg aggaagtcta 6060tgccaaaatc ctttttatca aaatattctc
gaaggcagtg cagtcactaa ctctgatttc 6120ctaagaaagg tgggcagcat
tagcagatgg ttatttttgc actgatgatt ctttaagaat 6180cgtaagagaa
ctctgtagga attattgatt atagcataca aaagtgattc agttttttgg
6240tttttaataa atcagaagac catgtagaaa acttttacat ctgccttgtc
atcttttcac 6300aggattgtaa ttagtcttgt ttcccatgta aataaacaac
acacgcatac agaaaaaaaa 6360aaaaaaa 636712829PRTHomo sapiens 12Met
Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr1 5 10
15Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser
20 25 30Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro
Lys 35 40 45Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile
Tyr Gly 50 55 60Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp
Leu Asp Pro65 70 75 80Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu
Asn Lys Gly Lys Thr 85 90 95Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu
Tyr Met Leu Ser Pro Phe 100 105 110Ser Pro Leu Arg Arg Ile Ser Ile
Lys Ile Leu Val His Ser Leu Phe 115 120 125Ser Met Leu Ile Met Cys
Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 130 135 140Met Asn Asn Pro
Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr145 150 155 160Gly
Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 165 170
175Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp
180 185 190Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn
Leu Gly 195 200 205Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg
Ala Leu Lys Thr 210 215 220Ile Ser Val Ile Pro Gly Leu Lys Thr Ile
Val Gly Ala Leu Ile Gln225 230 235 240Ser Val Lys Lys Leu Ser Asp
Val Met Ile Leu Thr Val Phe Cys Leu 245 250 255Ser Val Phe Ala Leu
Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 260 265 270His Lys Cys
Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 275 280 285Ile
Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 290 295
300Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr
Asp305 310 315 320Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys
Ile Gly Arg Asn 325 330 335Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr
Phe Ser Trp Ala Phe Leu 340 345 350Ala Leu Phe Arg Leu Met Thr Gln
Asp Tyr Trp Glu Asn Leu Tyr Gln 355 360 365Gln Thr Leu Arg Ala Ala
Gly Lys Thr Tyr Met Ile Phe Phe Val Val 370 375 380Val Ile Phe Leu
Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val385 390 395 400Val
Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 405 410
415Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys
420 425 430Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu
Tyr Thr 435 440 445Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu
Ser Ser Ser Glu 450
455 460Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg
Arg465 470 475 480Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu
Glu Lys Gly Asp 485 490 495Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu
Asp Ser Ile Arg Arg Lys 500 505 510Ser Phe His Leu Gly Val Glu Gly
His Arg Arg Ala His Glu Lys Arg 515 520 525Leu Ser Thr Pro Asn Gln
Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 530 535 540Ser Ala Arg Arg
Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg545 550 555 560Gly
Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 565 570
575Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His
580 585 590Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser
Arg Ser 595 600 605Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser
Ala Val Asp Cys 610 615 620Asn Gly Val Val Ser Leu Val Asp Gly Arg
Ser Ala Leu Met Leu Pro625 630 635 640Asn Gly Gln Leu Leu Pro Glu
Gly Thr Thr Asn Gln Ile His Lys Lys 645 650 655Arg Arg Cys Ser Ser
Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 660 665 670Asn Leu Arg
Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 675 680 685Val
Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 690 695
700Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp
Ile705 710 715 720Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp
Pro Phe Val Asp 725 730 735Leu Ala Ile Thr Ile Cys Ile Val Leu Asn
Thr Leu Phe Met Ala Met 740 745 750Glu His His Pro Met Thr Glu Glu
Phe Lys Asn Val Leu Ala Ile Gly 755 760 765Asn Leu Val Phe Thr Gly
Ile Phe Ala Ala Glu Met Val Leu Lys Leu 770 775 780Ile Ala Met Asp
Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe785 790 795 800Asp
Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 805 810
815Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 820
825132521DNAHomo sapiens 13tcgtcattgt ttttgcgtaa gtactttcag
ctttttgaaa cggcaaattt atgaaaatct 60caggcagcac agtgttccaa taacagcaaa
cctctggggt ctgatttttc cagcatggaa 120tgtctgtatt taaaggaaaa
tggaagctat atgaaagcta gtcattgata ggcaaatact 180aaatttttca
aaaagactat ctcccactca gaggtatgtg acatcattga gattgatcat
240cttcctccat gctcagcact tggatggata gtctatgcag tgccaattag
gtttacactt 300tttccaagtt cttgtttaaa aatgaataaa acctataaga
agcacacaaa aaactcaggc 360ctttaaatac aagtacagtg ctctttatat
taccctgtat tattcaatta ttttatattt 420ttgtattaaa atataaaagt
atatatttgt aaaagagctg tcactgctta ctaagcctaa 480gattaatgca
ttgtatacac attatatata cactcagttt attttcaagg aaaatattac
540attacagtat aattttaatt tattcataat tgttactctt ttcccaaatg
tatttatcag 600aaaaatggat ttttacaatc tcatatctag atattctatt
ttccgttaat gactttgaat 660tatcaaagta atccaggttc actggagcca
cctagacaat acagaagggt cttaagattc 720ctaatatccg attccttcat
ccctgcctaa cctcttttcc atcaggctcc ctccttttga 780ggtcacatat
gatggggcag ttccatctgc tacctgctgc taagaaaaca ttgtgcaaag
840aagactgcct cttctcatag gtctcctttt tttcctattg gtacaattca
aatactacaa 900aattcacaat tttaaagtat acaattcagt gtttttcagt
atattgacaa acttgcgcaa 960catcaccact acctaattag agaagtttaa
caaccccaaa tagaaactct gtactcatta 1020gcagtcactt caatttcctt
ctctccctgg ccccttggaa accactcatc tatgttttat 1080ctctatggat
ttgtctattt ggattttttt atgaatggaa atatcaaaca gtatgcagcc
1140ttttgtgtct gacacttagc atactatttt caatgtttta taaaaaatta
aaagtctaaa 1200ttaccataat gttaagggtc caacaattga aacatttagt
tgtttacgca tttaagtgta 1260tgaatccaat ttaataatat ataatatctg
tattttgttt gcatcaaatg agtcaaatca 1320atgctaatta aattaagtta
gttatgatag caaaaaagac ttgcagaact atacatttaa 1380aatagaagcc
ccaaacgtag aaaatacctt gactaaaggc tcaggtaagt atcatagact
1440ctatctaaat tctgaataat tctgatttaa ttctacaggt atttaacaga
atttgtaaac 1500ctaggcaatg tttcagctct tcgaactttc agagtattga
gagctttgaa aactatttct 1560gtaatcccag gtaagaagta attggtgtga
agcattaggc cactcataac tccaactatt 1620tgggagttgt tctttgttcg
tttgtgtgtg tgtcgtcact gtgtgtataa actcccctat 1680tacagatatg
tgacagagtt tgtggacctg ggcaatgtct cagcattgag aacattcaga
1740gttctccgag cattgaaaac aatttcagtc attccaggtg agagtggggt
taaacaccag 1800ggctgacttt gatcttttga aagaaagaca taaaaaaaac
ctttctttat gcaattttaa 1860ttaaatttga tttcttctgt tttccacaat
cattatcaaa agtcaacctt tgagtttaat 1920caattgcatg ggtctttagg
atgaggatga ctacttggct cacatctcaa cttgaaatct 1980tccctcctgt
ctgagggttt gtttttccat ttgcttatac aggaaggaaa atttcaatcc
2040attttaattg attttaaaat acttaggaaa gagatcataa atatcagcat
ggggatattg 2100catgacattg ttttttattt tttctcagca aaccatttct
ttattgaaaa ttattacaag 2160gtgtcactat atgctgtaat ttgttttggt
gccatttata gagaagtggt ttgtttgaca 2220aacattagaa cttacaaaaa
ttatttttaa agtggtttga atagccaaat tgttcatttt 2280gacaacctag
gtattctttg agaatatgtt cctattttta accatttgct gtaatatata
2340aaaacaaagt atatataaaa tagcaaaccc agaaggcttt ttttgaatta
ggttacttaa 2400ggtcattgat ttgatataat gcatgacttt ctaggaaagc
ttgtgttttt tgtttcgatt 2460cagaggcttt atgtcattac aaacactttt
ttctcccatt ttcaggcctg aagacaattg 2520t 2521149963DNAHomo sapiens
14aaatattaaa acattgaaaa actttttttt accctttttg gtttatcatc ttccttctct
60ccttcaactt ccattttttt cattcagttt ttcccctcat tccaactctt ctttctttaa
120ttgaacataa tagagactcg gagttcaaaa tatgtgttgt ttctattgaa
ttgatagatt 180tttttttttt ttttgagaca gggtctctgt ctgtcatcca
agctggaccg cagtggtgtg 240atcatggctc actgcagact caacctcccc
aggctcaggt gatcctccca ccttagctac 300tctcaagcag ctgagactac
aggtgcacag ctccatgcct ggctaatttt tgtacttttc 360ctagagacag
ggtgtcactg tgttgcccat gctgttcttg aactcctgcc ctcaagtgat
420tcacccgcct tggcctccga aaatgttgga attacaggca cgagccactg
tgcctggtct 480attgaatgga atttatgttt atcctttcca attttaaaat
agttaacttt aaagttgtgt 540attttacatt cattgtcttc aaaccaaaca
aaatccaaaa acttttctac tttttgaatt 600gaattttttc tctccttttg
aataataaaa cctggtcatt gatgtatgtg tactcatctg 660atatttttga
tttaacaaaa tcaaatggag ggttcacgtt agtattttat gctttttaaa
720agtagacatg cttatgctct tccctaaaac ttttatttca gcattactta
gataagccct 780ggcatctgta tttttttagg ttacacagat gatttttttg
tataccctgg tcaatagcca 840cagtggagta tacctgcatt ctgatatata
cactcttgac aaccatagag acaaatgata 900cttagctgca tttttaacat
tacctaacat aagtgaaagg gattttaaaa cagtagtatt 960ttggaaaaca
gcagataata aaacattaat tttgtgttgt gggttattgg tattaagtat
1020catgtaatgc ccacatctca aagctcacta tggaagaatt ggtgtcagat
aataggaaga 1080ttgatattgt tgaaaaccat gcattcagca agccagccat
tggtagcacc caatgaagtg 1140ttcagtattc atctaagcag agaaagtaga
agacacaatc tttactgtaa ctttgagtgt 1200ttgcagtgtg tcagatggtc
ccttgaagaa gaaatattaa taaaaatgaa ttgcaaattg 1260tctccaattt
acctgaaaga gatcaaaata atgtatctaa atatatggtg tttgaaaggt
1320gtagagtcag tccatatttt tcaagcccag tgaaggtaac agaacagttt
ctacttaagc 1380agctgtttgt tggtttcttt ggctcaagag agaggtataa
tatcttcttt tattttacag 1440ctttttaatc ataataataa ctattataaa
attaacaaat gcacatggta actaattcaa 1500acaatttttg ctttatccct
ttaaagccat tatctaggga ataatcactt cccgcttttt 1560taaaaaaaag
tttttctgat attttccttt ttatctctaa ataatatgct tatgtctcat
1620ttttatttca tcaacttatg taatgttttc taactttcta atttgaaaat
gaggaattta 1680ttttatttat gtaaactttt ctctttctgc cccattctca
aattccaagc agttatgttt 1740tcatttctaa gtaattctat gggttggatt
tataccttta aatggaatat acctgaacct 1800ctatttcttg ttacttaaac
tttagccagg atgcactaac tgccttcaat gtaagataag 1860gggtcagctc
tccaactttt ccctcaccac taatccccct ctacctctca atttttgtaa
1920gctattccat tacttttaca ctgataatat ttaacacata tatgtgtata
tcttgtcttt 1980gtgtaaataa agttctataa ttgtacttac attttatata
tgctttggta attggcacat 2040ttgtgagatg attaactgat acaatttaac
aatattataa ttatgtatgt atttttcatt 2100ttaaaacaag taacatggtt
tgatctagag gaggaattta aacctctcat tcaaactctg 2160ctacttgaag
aacacatcaa actcaagtgg atcctctctg cttcaattct accagttgtt
2220caagttcatg cctcattttg aattgattcc tatttggaca atatggctat
ttacacgttc 2280taaagaaaca aattcccttt gcttttattc acactatttg
tgaaacatct tgtattctat 2340gtgttttaga agtacttttt tttttttgct
ctaccttaat ccaaagtaac ttaaaaaaaa 2400aagataaaaa ggagttaaat
tttgaatttt cttataccta gaaatatatt ttgtttgcca 2460tcacacttga
taataggttg tctgataata gaatttgatt caaaatattt tctctcatca
2520cactgaaagc attgattgtg ttctagtgtc aattatggct aaggaaattt
taatggcaat 2580ctaattttca ttctttttag ttagttatct tatttttgga
agattataaa atcttgtttc 2640tattgttaat gctctaaact ttcacaagaa
tggaactttt aaattgatct tcttttgtac 2700ttttagcttg atgactcttg
gtgaattttc tgccattact ttgtttatta tttcctatct 2760actatttgct
gctctcttga gactaatgtc gaacaacatg gattattctg tatcttctaa
2820gttttatttt gtactttttt aatttttaaa attctcctaa aatatataga
aaaatctaag 2880atatagaact ccatgcattt ttacatatac atattttccc
atgtaaccat cacatagatc 2940aaggtataga acgtttctag cacctgagaa
tgctcactgg tgccccattc tggtaaagtg 3000ccccttttgg gtaaagtaaa
aggtaactac aattatgact tctccttttc agcaagcatt 3060ctactgaaat
tttttgtttc acaaagcatg acctttaccc agaattgatg ttgttgtttt
3120tggtagccta tttttttttt ttaataaaag atactctgtc tcctcaaatt
tctctaggaa 3180tactaacttt aacttctcaa tatcccacaa tgtttgcttt
tttttttcta aagttaaaag 3240tttggtctgt tcatcttagt ctttcaattt
tatgtttggt agatcttcat taccaattta 3300ttcttgataa tctattaata
tttatggaag aaaggccagg ttggtgttgg ccaggtttgc 3360atctgtcttt
atacaggtct gtttcccaga caaatcctct cttgaaagag agggatgact
3420gaaaggtctg tgtatataca tgtatggtgt actgacaggc aggctacatt
ttaggatgta 3480tggatgagga gtagataagg gagtcacctt tccctcgact
ccaccctggt tctagctaaa 3540atggacatgg ataccctagg agtcctacct
taattaatgc agatattatc cttttggtga 3600tagcttggag ataaaccact
ctgctacata tttaacatag agagggaagt gggacaatgt 3660tttctgcaac
attattgaat aaataatcca tggattaatc aacttgtttt ctgatctaca
3720tcacatattt gccatagaaa tctgtgactt ctctgctaga aagaaattct
aacattctca 3780gatgagtgtt ctagactgta gcttctgctt tgatctcctc
actagggtaa tcttatgatt 3840tatgataact ttttttgtct tcctctggtt
tttagtgata ttatctaaca tttcgccact 3900gtacatcttt gtttttactg
caatggaaat ttgaaggcca gagagtgtga taaacacatg 3960ggataagacc
attttcatga actgggagct gacattgctt tgactggaaa gatgtgtgaa
4020gaaaaataga tgctagatag acaaatacat gatatgatat ttggacagac
atagatccat 4080agatggataa gcatagataa aacatatcta tatatatgtg
tgtgtctgca tacatagaaa 4140ataagaaaga gttcagaata aatatttcca
tattgatttt aactatagga aatcttagat 4200acaagaataa cacattcatt
ttttaatttt agtagttgcc taagtattct ctaatatgag 4260attaatggtg
agtgggtaag atagtaatga gaaaacaaaa gtactgcctt tatatgcaac
4320attgggattt cattctaaag aagatacaat catagtaatg ttaataaaag
tggaaatgta 4380gcaatatatt tttcaaaatt gtaaattaaa catgacaaga
ataaatattg attgatttca 4440ttgactatat aaaattaggt caaataattt
taaatgattt ttttcaaagt atattttctt 4500tcttctggat agaaaaacat
gacattttcg ttgtacaaat ttgaaaagta aagtataaag 4560acataaaaat
aatccataat ctcttaacta gggctaaact ttgttaaatg cattgtgtat
4620ttaaattaaa tatcatttta aaaattatta ttaatttaca tctatctgtg
tgtataacct 4680ggattccact tattatgcat tatattttta taattcattt
aattcattaa atagtctttg 4740aacgctctct ttcaaagctg ctcattattt
cattatacat tcattacttc atttagtgta 4800acccttactg ttaggatttt
ggattgatta taatttttca atattataaa aatattgtag 4860taaatatatt
tatacatgtt agaggacacc tgagattact gtctttgaat aaattcctag
4920aaggaaaatt atttggcaat ataaacgaat tcacgtgttt aaggcttttg
atagatatta 4980caaaattacc ctcaaaaagt ttgtacactt tatttattta
tttgagacgg agtctcgctc 5040tattgcccag gctggagtgc agtggcacga
tcttggctca ctgcaagctc cgcctcctgg 5100gttcacgcca ttctctgcct
cagcctcccg agcagctggg actataggcg cctgccaaca 5160tgcctggcta
atttttttgt acttttagta gagacagggt ttcacagtgt tcgccaggtt
5220ggtctcgatc tcctgacctc atgatctgcc tgcctgggcc tcccaaagtt
ctgggattat 5280aggcgtgagc caccgcaccc agacagtaca cattatttat
tactttcatc cagacaggca 5340acactgattt cccctataac ctctctaata
tcactattac ttttgttaaa atctttgcta 5400atgattaata ggccaaattt
ggttccccat gtttatttta atatttgttt ctttgattac 5460tagtgaggtt
tgacatggtt acaagtgttt attaaccatt tgtattttta gataattatg
5520ttttttacta aattttatga gatatattaa tatctttatt cattaaagga
aaagcacttc 5580atctgtcatt tgtattgtac tttttttatt ttgtggatgc
cttccacttt taaaaacctt 5640cattgttatg agattaaatc tagcattctt
tatctttttc gattttgcct ttggtgtaat 5700gctttacaag tcctctctac
tctcacatta aataagtatt cattttcact tttattagaa 5760tgtttgagct
ttatttttcc atttaaatat ttactccacc agaaatctca aatcttaaac
5820taaatgcctg actaatgaaa actcctgtgg cctgtttatc cagaagacta
agggaagagg 5880aaagaagttg tagtcacaca taggtcctgc cccatcattg
catcttcttt gtgtgtgttg 5940gtgaagtgtg aggctccatt tttacttatg
ttgccctctg taaccctgtc agcctatcat 6000cttgccaccc cactggcctg
gtacaataac ttccaagcaa actcagatgc caactaaagc 6060tgctcttctt
caaagctata aaattagtaa aatgaaagga agtttcacct ctccaaacta
6120gaggatgatg atgaaatctg atcaaggtct cttcaacttc catttcacag
atcatgatgt 6180taagcaggtg cttagtgtct tcctttaatt tagcttgatc
agggaaatat tgcccatgca 6240tggtaccact agcattgacc accctttgcc
tctgcttttt tcatatactt tagtcattct 6300ggagctgtgt tgagcatgtg
catgggggtt gggggagaca gagacagagg agaataggaa 6360tattggaaga
atcaaactgg taatggacat ctgagttcac aacatctttg tacctagatt
6420tctgtcaaat aattcttgaa agagatggta ccctccagtt gaatgtagaa
tctacaaaaa 6480caccagttat tcaagccaac ttttcttcaa gagccacagt
atgtctacac tgaaagtcta 6540gtgaggcaag ttatcccgtc ttctcacctt
tatgatttcc aaaagtgttg aggaatctcc 6600aaagcacaag tggcaactgc
tttgatttga ttcattgatt tgtttccttt ttactaaatc 6660tcttcctatt
ctgaggacaa ttttcacata ttttaggatt caaaattctt aatgcatatt
6720catagtagtt ttattaagat ataatttaca caccataaaa aatcaccatt
ttaaagtgta 6780tcactcagtg gtttttagta tgttcacaaa ggtatgcaac
aatcatcatt atgtagtttt 6840agaatatttt tatcacccca aaagaagccc
catactcttt aaccattaac cacataacca 6900tcaataatca cttcctatta
cacccagcct ctgacaaaaa atactctaca ttttgtttct 6960ggggatttgc
ctattctgga catttcataa gatggaatca tatcgtatgt ggccttttgg
7020ctctgtgttc tttcacgggg ttttcatcac atccatgttg taacatgtac
ctatacttca 7080tttgttttta ttgctaaata ctaattcagt gtttgaatat
cccacattcc tttatccatt 7140tattcattgg tgagtaatga ggttgtgttt
actttttggc tagtatgaat aatgctgctg 7200aacattcatg taaacgttct
tgtgtggaca tatgttttaa attcccttga gtctgtacca 7260agtagtggaa
ttgccgagtc ataacttact ctttaccttt cagaatcatc ctacttttga
7320atgtgtatat gaaatatccc ttatttttca ctacattctt taaaaacctt
tatcctaact 7380ttggtttcca tcaaaataca ggcatacttc attttatggg
gctttacttt attgcacttc 7440aagatactgc attctttaca agttgaaggt
ttgtggcaac cctgcattaa gcaagtctgt 7500cagcgtaatt ttttcaacag
catgtgctca cttcatgcat ctgtgtcaca ctttggcaat 7560tctcacaata
tttcaacttt gtaattgcca ttatttaatt attactgtat gtgttatggt
7620gatctatgat cagtgatctt tgttgttact gtggtaattg ttttggggtg
ctatgaacca 7680catccacata agacagcaaa caatcattaa atgtgacgtg
ttctgtttca gcatccctat 7740ctctctccct ttcctcaggc ttccctgttc
cctgacacac aacgatgtta aaattaggcc 7800aattagtaac ccattcccac
ccctaatgtt caagtaaagg aagaattgcg catttctcac 7860tttaaatcag
aagctagaaa tgattaagct tagtgaggaa ggcatgttga aagccaagat
7920aggccaaaat ctaggcctct tgcactaagt acttagccaa gttgtgaatg
caaaggaaac 7980attcttgaag gaaatcaaat gtgctactcc agtgaacaca
tgaatgataa gaaaacaaaa 8040cagccttatt gcaaatatag agaaagtttt
agtgatctag atagaagatc aaccagccac 8100aacatttcct taagccaaag
cctaatccac agcaaggcca taactccaat tgtatgaagg 8160ctgagaggtg
aagaagctgg aaaaaaaagg tttgaagctg gcagacggta ccccatgaga
8220ttgaaggaaa gaagtcactg ccataacata aaaatgcaag gtgaaacagc
aagtgccaat 8280ggagaagatg cagcaagtta ttcagaagat ctagctaaga
tcattgataa gagtggttac 8340attaaacaac agatttgcaa tgaaggtcta
acagccttct actagaagaa tatattatag 8400ctagaaagga gaagtcaatg
tctggcttca aagcttcaac gaacaggctg actctcttgt 8460taggggataa
tgcagctggt gactttaaat tgaagcaaat gctaatttat cgttcagaaa
8520atcttagaat tatattattt aattattcag aatattaata attatttact
attcagaaaa 8580ttacataata attatattat ttactattca gaaaattaca
taataattat attatttact 8640attcagaaaa ttaaataatt atattcttta
ctattcagaa aattaaataa taactatatt 8700atttaattat tcagaaaatt
aaataataat tatattattt aatcattcag aaaatctctt 8760aagaattata
ctaaatctac tctgcctgtg ctctataaat agaacaacaa agcctggatg
8820acagcacgtc tgtttacagc atggttcact aaatatttta ggcccagtgt
tgatacttat 8880agctcaggaa aaaaaaaaaa gatttctttc aaaatatcac
tgcctattga caatgtgcct 8940ggtcactcaa gagctctaac ggagaggtac
aagggcatta atgttatttt catgcctgct 9000aacgctatcc attctgtagc
ctatgggcca aagagtaatt tcaactttta agtcttattt 9060tttaataaat
acattttata agactatagc tgccatagat agtgattcct ctgatgggtc
9120tgggaaaagt aaattgaaaa tcttctggaa aggattcacc attctagatg
ttattagaac 9180attaatgatt tgtgggagga gggcaatata caaacattaa
taggaaattg gaatgagttg 9240attccaactc tcatggatga ctatgagagg
tttaagactt cagtgatgga aagaactgca 9300gatgtggtgg aaatagcaag
agaattagaa ttaagagatg gagcctaaaa ttgtgactga 9360attgctgcca
tctcgcggta acttgaatgg atgaggagtt gcttctgatt gataagcaaa
9420gaaagtggtt tcgtgagatg gaatcttctc ctggtcaaga tgttatgaac
attgttgaag 9480tgacagcaga ggatttagaa tattacataa gtttagttgg
taaaacagca tcaggctgga 9540gagtggtgct accaaaggca ttatcataaa
gacttttaaa agaggaaagt tgagttgaat 9600tgcaccaaag gtaaatatag
acgaaaagaa ggggaattta ggaaaattta ctcagaaaat 9660tgtcattttt
tactttaaag ctatgaagcg taaacttcaa atttctgagt ataaagatgg
9720ttagaaggca cgaaagataa gtcccgccca ttgcctgaca catagtaatc
ccttaacaag 9780ctgataattc tagaacatgt taccttttgt agttgaaact
aaaaatctgt ttatgttgtt 9840attattagtt tttaatgggc ctttcttggc
aggcaaatag ttaagtcttt atttctttgt 9900ttccatccag gcctcttatg
tgaggagctg aagaggaatt aaaatataca ggatgaaaag 9960atg
9963159298DNAMus musculus 15tacaggatga gaagatggcg atgttgcctc
cgccaggacc tcagagcttc gttcacttca 60caaaacagtc ccttgccctc attgaacaac
gcatttctga agaaaaagcc aagggacaca 120aagatgaaaa gaaagatgat
gaggaagaag
gtcccaagcc cagtagtgac ttggaagcag 180gtaaacagct acccttcatc
tacggagaca ttcccccggg aatggtgtca gagcccctgg 240aggacctgga
cccatactat gcagacaaaa aaacttttat agtattgaac aaagggaaag
300caatcttccg tttcaacgcc acccctgctt tgtacatgct gtctcccttc
agtcctctca 360gaagaatatc tattaagatt ttagtgcact ccttattcag
catgctaatc atgtgcacaa 420ttctgacaaa ctgcatattc atgaccatga
gcaaccctcc agattggacc aaaaacgtag 480agtacacttt tactgggata
tatacttttg aatcactcat aaaaatcctt gcaagaggct 540tttgcgtggg
cgaattcacc ttcctccgtg acccttggaa ctggctggac tttgttgtca
600ttgtttttgc gtatttaaca gaatttgtaa acctaggcaa tgtttcagct
cttcgaactt 660tcagagtctt gagagctttg aaaactattt ctgtaattcc
aggactaaaa accatcgtgg 720gggccctgat ccaatcagtg aagaagctct
ctgacgtcat gatcctcact gtgttctgtc 780tcagtgtgtt cgcactaatt
ggactacaac tgtttatggg caacttgaag cataaatgtt 840tccggaagga
ccttgagcag aatgaaacat tagaaagcat catgagtact gctgagagtg
900aagaagaatt gaaaagatat ttttattact tggagggatc caaagatgct
cttctttgcg 960gtttcagcac agattcaggg cagtgtcctg aagggtacga
gtgtgtgaca gctggcagaa 1020acccagatta tggctacaca agctttgaca
cgttcggctg ggccttcttg gccttgtttc 1080ggctaatgac tcaggactac
tgggagaacc tttatcaaca gacactgcgt gctgctggca 1140aaacctacat
gattttcttt gtcgtggtga tatttctggg atccttttac ctgataaact
1200tgatcctggc tgtggtagcc atggcgtacg aggaacagaa ccaggccaac
atcgaagaag 1260ctaaacagaa agagttagaa tttcagcaga tgttagaccg
actcaaaaaa gagcaggaag 1320aagccgaggc gatcgctgca gccgctgctg
agtacacgag tttagggcgg agcaggatta 1380tgggactctc tgagagctct
tcagaaacct ccaggctgag ctcaaagagt gccaaggaga 1440gaagaaaccg
aagaaagaaa aaaaaacaga agctgtccag tggcgaggaa aagggtgatg
1500atgagaagct gtccaagtca gggtcagagg aaagcatccg aaagaaaagc
ttccatctcg 1560gcgtggaagg gcaccaccgg gccagggaaa agaggctgtc
cacccccaac cagtcaccac 1620tcagcattcg tgggtccttg ttttctgcca
ggcgcagcag cagaacaagt ctcttcagtt 1680ttaaggggcg aggaagagat
ctgggatctg aaacggaatt tgctgatgat gagcatagca 1740tttttggaga
caacgagagc agaaggggtt cactatttgt accccataga ccccgggagc
1800ggcgcagcag taacatcagc caggccagta ggtccccacc agtgctgccg
gtgaacggga 1860agatgcacag tgcagtggac tgcaatggcg tggtgtcgct
tgttgatgga ccctcagccc 1920tcatgctccc caatggacag cttcttccag
aggtgataat agataaggca acttccgacg 1980acagcggcac aactaatcag
atgcgtaaaa aaaggctctc tagttcttac tttttgtctg 2040aggacatgct
gaatgaccca catctcaggc aaagggccat gagcagagca agcattctaa
2100ccaacacagt agaagaactt gaagaatcta gacaaaaatg tccaccatgg
tggtacagat 2160ttgctcacac atttttaatc tggaattgtt ctccatattg
gataaaattc aaaaagttca 2220tctattttat tgtaatggat ccttttgtag
atcttgcaat taccatttgc atagttttaa 2280acaccttgtt tatggctatg
gagcaccatc caatgacgga tgaattcaaa aatgtacttg 2340cagtcgggaa
cctggtcttc acagggatct tcgcagctga aatggtactg aagttaatag
2400ccatggatcc ctatgaatat ttccaagtag ggtggaatat ttttgacagc
ctgattgtga 2460cgttgagttt ggtggagctt ttcctagcag atgtggaagg
attatcagtc ctgcggtcct 2520ttagattgct gcgagtcttc aagttggcaa
aatcctggcc cacactgaat atgctcatta 2580agatcatcgg caactcggtg
ggcgcactgg gcaacctgac cctggtgctg gccatcatcg 2640tcttcatttt
tgccgtggtc ggcatgcagc tgtttggaaa gagctacaag gagtgtgttt
2700gcaagatcaa cgagaactgc aagctcccac gctggcacat gaacgacttc
ttccactcct 2760tcctgatcgt gttccgtgtg ctgtgtgggg agtggataga
gaccatgtgg gactgcatgg 2820aggttgcggg ccagaccatg tgccttattg
tttacatgat ggtcatggtg attgggaacc 2880ttgtggtcct gaacctgttt
ctggctttat tactgagttc ctttagttct gacaatctta 2940cagcaattga
agaagacacc gacgcaaaca acctccagat tgcagtggcc agaattaaaa
3000gagggatcaa ttatgtgaaa cagaccctgc gtgaattcat tctaaagtca
ttttccaaaa 3060agccaaaggg ctccaaggac acaaaacgaa cagcggatcc
caacaacaaa agagaaaact 3120atatctcaaa ccgtaccctt gcggagataa
gcaaagatca caatttcctc aaagaaaagg 3180ataagatcag tggttttagc
agcagtctag acaaaagctt tatggatgaa aacgattacc 3240agtcctttat
tcataatccc agcctcacag tgacagtgcc cattgcacct ggggagtctg
3300atttggagaa tatgaacaca gaagagctta gcagtgactc agatagtgac
tacagcaaag 3360agagacggaa ccgatcaagt tcttcagagt gcagcacagt
tgataaccct ctgccaggag 3420aagaggaggc agaagctgag cctatcaatg
cagatgagcc cgaagcctgt tttacagatg 3480gctgtgtgag gagatttcca
tgctgccaag ttaacataga ctccgggaaa gggaaagttt 3540ggtggaccat
ccggaagacc tgctacagga tagtggagca cagctggttt gaaagcttca
3600ttgttctcat gatcctgctc agcagtggag ctctggcttt tgaggatata
tatattgaaa 3660agaaaaagac cattaagatt atcctggagt atgctgacaa
gatattcacc tacatcttca 3720ttctggaaat gcttctaaaa tgggtggcat
acgggtataa aacatatttc actaatgcct 3780ggtgttggct ggacttctta
attgttgatg tgtctctagt tactttagta gccaacactc 3840ttggctactc
agaccttggc cccattaaat ctctacggac actgagggcc ctaagacccc
3900taagagcttt gtctagattt gaaggaatga gggtagtggt caacgcactc
ataggagcaa 3960tcccttccat catgaatgtg cttcttgtgt gccttatatt
ctggctaata tttagcatca 4020tgggagtcaa tctgtttgct ggcaagttct
atgagtgtgt taacaccaca gatggctcac 4080gattttctgt atctcaagtt
gcaaaccgtt ctgagtgttt tgccctgatg aatgttagtg 4140gaaatgtgcg
atggaaaaac ctgaaagtaa acttcgataa cgttggactt ggttacctgt
4200cgctgcttca agttgcaacg ttcaagggct ggatggatat tatgtatgca
gcagttgact 4260ctgttaatgt aaatgcacaa ccaatatatg aatacaacct
ctacatgtac atttattttg 4320tcatcttcat catctttggc tcattcttca
ctttgaactt gttcattggt gtcatcatcg 4380ataatttcaa ccaacagaag
aagaagcttg gaggtcaaga tatctttatg acagaagaac 4440agaagaaata
ctataatgca atgaagaagc tggggtccaa gaaaccacaa aaaccaattc
4500cgaggccagg gaacaaattc caaggatgca tatttgactt agtgacaaac
caagcttttg 4560atatcaccat catggttctt atctgcctca atatggtaac
catgatggta gaaaaagagg 4620ggcaaactga ctacatgagt tttgtgctat
actggatcaa cgtggtcttc atcatcctgt 4680tcactgggga gtgtgtgctg
aagctgatct ctctcaggca ttactacttc actgtgggat 4740ggaacatttt
tgattttgtg gtagtgatcc tctccattgt aggaatgttt ctcgctgaga
4800tgatagagaa gtatttcgtg tctcctaccc tgttccgagt cattcgcctg
gccaggattg 4860gacgaatcct acgcctgatc aaaggcgcca aggggatccg
cacgctgctc tttgctctga 4920tgatgtccct tcctgcgctg ttcaacatcg
gcctcctgct tttcctcgtc atgttcatct 4980acgccatctt tgggatgtcc
aactttgcct acgttaaaaa ggaagctgga attaatgaca 5040tgttcaactt
tgagaccttc ggcaacagca tgatctgcct gttccaaatc accacctctg
5100cgggctggga tggactgctg gcccccatcc tcaacagtgc acctcctgac
tgtgacccaa 5160aaaaggttca cccaggaagt tcagtggaag gggactgtgg
aaatccatct gtgggaattt 5220tctactttgt cagctacatc atcatatcct
tcctggttgt ggtgaacatg tacattgctg 5280tcatcctgga gaacttcagc
gttgccacag aagaaagtac tgagcccctg agtgaggacg 5340actttgagat
gttctacgaa gtctgggaga agttcgaccc tgacgccacc cagttcatag
5400agttctgcaa gctctctgac tttgcagcag ccctggatcc tcccctcctc
atcgcaaagc 5460caaacaaagt ccagctcatt gccatggacc tgcccatggt
gagtggagac cgcatccact 5520gcctggacat cttatttgct tttacaaagc
gggtcctggg cgagagcgga gagatggatt 5580cccttcgttc acagatggaa
gaaaggttta tgtcagccaa tccttctaaa gtgtcctatg 5640agcccatcac
aaccacactg aagcgaaaac aagaggatgt atctgcgact atcattcagc
5700gtgcttacag acggtaccgc cttaggcaaa acgtcaagaa tatatcaagt
atatatataa 5760aagatggaga cagagatgac gatttgccca ataaagaaga
tatagttttt gataatgtta 5820acgagaactc aagtccagaa aagacagatg
caacagcctc taccatctct ccaccttcct 5880atgacagtgt cacaaagcca
gatcaagaga aatatgaaac agacaaaacg gagaaggaag 5940acaaagagaa
agacgaaagc aggaaataga gcttcggttt tgatacactg tttacagcct
6000gcgaaggtga ctcactcgtg ttaataagac tcttttacgg aggtctatgc
caaactcttt 6060ttatcaaata ttctcaaagg cagcacagcc actagctctg
atccagtgaa acaagagaga 6120agcatttaca catggctact ttttgcgttg
gtcaatgatt ctttaagaat tgtgcatgta 6180actctacagg gaataatcat
tattgcaatc aagggtgact taatgatttt aaatatcaga 6240aaaccacata
gaacattttc tcttttgcct ccatttcttt ccctagattc taagtagatg
6300tgtacccatg tgaatataga aattcaggcg cacatgctca cagtcacaaa
cacaaacagg 6360attagctgtg atttggaatt cgatgtaaat atttcacctg
tgatttgcaa tgaaattcct 6420tgtaaaagaa atgcgaatta gtgatgaagg
ttttgtgaaa acatcttatc attagggagt 6480cagaatttct gtccataaag
aattcagttt atattttgag gtgctgaaac ttatcctaca 6540ttgcatcaaa
atcaatttat aggtatctgt aaaatgtcat gggactgaaa aacatatata
6600ggctacttgt ttaagaaatg gctttcattc atatagatag gcattcacct
tgatttatgg 6660acatctttgg cattttgtga tcacatgatt cttccacaaa
attgcttagc tggaacttca 6720ggcacacatc acagagaaca gctacccagt
cttatgcccc tctctgtttg tacaataatc 6780acagagcttg aaacattatt
tgaactataa atatcaggtt tctccacata gacatatgaa 6840tattgttaac
agaaaaaaat tttatttaca gcgttttatt tactaatatt tatccaatct
6900agtttgccca atgagacagc tcatgactca catctgaaag ccagttgcca
catttatctt 6960cttatgtaac tttggtttgt catactttat gtctaagcaa
attgaatgtc tcctttctaa 7020tgagatgtac cctgaaatgc agttaggtac
ttgatacttt agcgcttgtt tgagcagatg 7080actggagcac agtgtggact
gcatctctta aatacaatcc ttaatgtgtt tggcagcttc 7140tcaggttaca
aggaacaccc ggcttttagt gtctatctgt tcaccaggtg tttagtatga
7200atgaaacggc attcaaagag tgagtctcac tggcttgctt tattactgat
gccttcccta 7260tggagaatta atcctctgaa gccccattat gtccccctgt
aaataatgta gatgtcactt 7320ccttcttaat attctaatcc atactgtgaa
atcgattttg catttatcgg tcaaatagag 7380cattttgaga tagttggagt
taccctgcca aggattagaa atctacttca tgtttttaaa 7440gtacttgtta
aaaatgaacg accctggcac attctctcat aattttattc cagccatgtg
7500aaatctttct tctaaacact ttatccttgc ggaggaaaaa aaaaatgagc
tgatgagcca 7560tttaagcaca aaggggcttt atttagaaga ttccaagggg
gaactttgaa gtaaatatat 7620aaaacatact tcatcaattt gcctataaaa
ctaaaagagg aacacaggaa tattgataaa 7680ataagtcatt aaaacacatt
ctttatttct tgcccagttt aaaagaaaga actaaacatc 7740cctagagaga
ggaagagaca tagagagaga gtgactaata gaaagaggga gagaagaaac
7800aaggcaccaa ggacaaaaag agataattag acagaacttg tccaggtttt
cacactatgt 7860gctctgtcca gtaccgtaca caagaacctc tttccaaata
tttgtcctaa ggctctaaga 7920agttaagtac gaggctgaag gttgaataca
actgtcttta atcattaaca gtttggggag 7980ctacttttaa acgtctatgg
aagatgccaa gcagtggtaa gccagacaat acagagcact 8040gcatatctgt
caagcagctg aaatatgttt gggcaactta atggtgagcc acacaaaaca
8100tccatttgta acaattttaa tacattcaat taagaaacca ggatttttat
tattttgcac 8160ccataaaaat ataactatat tgttcatttt tattgataga
gtatgtgtga atcttattga 8220ttatctgtaa tttactatta atgtttttac
agtgactgtt ttttttgtgt gtgtaaactt 8280aatatatgtc agcaactggt
tcctcaacac aatttttttt agcattacaa aaaaatgaac 8340aggtataaag
gttctctttt ttctacatca tgttgaacat attttgttct gaattacata
8400gttttaaatg taatattaag ttttatattc atatatgttt aacatcaaaa
tcactactta 8460tgacattgtt atcaatttaa aaaatagtat ttgacactag
gatagcattt aattaaagct 8520aaaaagctta caccccattt catgttgatt
agtgtttgga ctaactctaa aatgtcatca 8580atggaagcta gtcactgaaa
ttattttatc tattgtcata gaatggtgac tacccaaaaa 8640atataagtta
gcattaaata gaagaaagcg tacgtgacca caaatccatg cacagggttg
8700tgtgaagaca ggagaacctc atttttctgt tttgtctctt tccactgtgt
aaaaagtcta 8760catctgtggg ctatttctaa attcaaattg tcacaatttg
caatcataaa tgtttagcat 8820actttgtaga attttgatag ttttgtaaaa
gagtgaaaaa caaatgcata tgtaaataaa 8880gcagcccata ctagcagatt
cctcaaatgt taatatgtaa ataaagcagc ccttactagc 8940agattcatca
aatgttaata tgtaaataaa gcagtcctta ttagcagatt tgtcatatgt
9000taaggggagt aatgataagg aggcaactaa atcaggatgg tcagtaactg
atctgggttt 9060agaactgtgt ttggagccat caatttttaa atatatgttc
tcactatgtt attagttgtc 9120tgaagaagca atcaagaatt gctcccagaa
aatgagtaag tagccatgaa tatatgaatg 9180ctgtttacag aacccataga
cctatgaatg ctcaaaatgt ttgggtttgt caaaaaatta 9240cattgtagtt
atacttgata cttaaaaact gttaatagag tctaaaataa aagtcgct
9298161984PRTMus musculus 16Met Ala Met Leu Pro Pro Pro Gly Pro Gln
Ser Phe Val His Phe Thr1 5 10 15Lys Gln Ser Leu Ala Leu Ile Glu Gln
Arg Ile Ser Glu Glu Lys Ala 20 25 30Lys Gly His Lys Asp Glu Lys Lys
Asp Asp Glu Glu Glu Gly Pro Lys 35 40 45Pro Ser Ser Asp Leu Glu Ala
Gly Lys Gln Leu Pro Phe Ile Tyr Gly 50 55 60Asp Ile Pro Pro Gly Met
Val Ser Glu Pro Leu Glu Asp Leu Asp Pro65 70 75 80Tyr Tyr Ala Asp
Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 85 90 95Ile Phe Arg
Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 100 105 110Ser
Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 115 120
125Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr
130 135 140Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr
Phe Thr145 150 155 160Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile
Leu Ala Arg Gly Phe 165 170 175Cys Val Gly Glu Phe Thr Phe Leu Arg
Asp Pro Trp Asn Trp Leu Asp 180 185 190Phe Val Val Ile Val Phe Ala
Tyr Leu Thr Glu Phe Val Asn Leu Gly 195 200 205Asn Val Ser Ala Leu
Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 210 215 220Ile Ser Val
Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln225 230 235
240Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu
245 250 255Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn
Leu Lys 260 265 270His Lys Cys Phe Arg Lys Asp Leu Glu Gln Asn Glu
Thr Leu Glu Ser 275 280 285Ile Met Ser Thr Ala Glu Ser Glu Glu Glu
Leu Lys Arg Tyr Phe Tyr 290 295 300Tyr Leu Glu Gly Ser Lys Asp Ala
Leu Leu Cys Gly Phe Ser Thr Asp305 310 315 320Ser Gly Gln Cys Pro
Glu Gly Tyr Glu Cys Val Thr Ala Gly Arg Asn 325 330 335Pro Asp Tyr
Gly Tyr Thr Ser Phe Asp Thr Phe Gly Trp Ala Phe Leu 340 345 350Ala
Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 355 360
365Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val
370 375 380Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu
Ala Val385 390 395 400Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala
Asn Ile Glu Glu Ala 405 410 415Lys Gln Lys Glu Leu Glu Phe Gln Gln
Met Leu Asp Arg Leu Lys Lys 420 425 430Glu Gln Glu Glu Ala Glu Ala
Ile Ala Ala Ala Ala Ala Glu Tyr Thr 435 440 445Ser Leu Gly Arg Ser
Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 450 455 460Thr Ser Arg
Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg465 470 475
480Lys Lys Lys Lys Gln Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Asp
485 490 495Glu Lys Leu Ser Lys Ser Gly Ser Glu Glu Ser Ile Arg Lys
Lys Ser 500 505 510Phe His Leu Gly Val Glu Gly His His Arg Ala Arg
Glu Lys Arg Leu 515 520 525Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile
Arg Gly Ser Leu Phe Ser 530 535 540Ala Arg Arg Ser Ser Arg Thr Ser
Leu Phe Ser Phe Lys Gly Arg Gly545 550 555 560Arg Asp Leu Gly Ser
Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 565 570 575Phe Gly Asp
Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 580 585 590Pro
Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 595 600
605Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn
610 615 620Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu
Pro Asn625 630 635 640Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys
Ala Thr Ser Asp Asp 645 650 655Ser Gly Thr Thr Asn Gln Met Arg Lys
Lys Arg Leu Ser Ser Ser Tyr 660 665 670Phe Leu Ser Glu Asp Met Leu
Asn Asp Pro His Leu Arg Gln Arg Ala 675 680 685Met Ser Arg Ala Ser
Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 690 695 700Ser Arg Gln
Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe705 710 715
720Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Phe Ile
725 730 735Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr
Ile Cys 740 745 750Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His
His Pro Met Thr 755 760 765Asp Glu Phe Lys Asn Val Leu Ala Val Gly
Asn Leu Val Phe Thr Gly 770 775 780Ile Phe Ala Ala Glu Met Val Leu
Lys Leu Ile Ala Met Asp Pro Tyr785 790 795 800Glu Tyr Phe Gln Val
Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 805 810 815Leu Ser Leu
Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 820 825 830Leu
Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 835 840
845Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala
850 855 860Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile
Phe Ala865 870 875 880Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr
Lys Glu Cys Val Cys 885 890 895Lys Ile Asn Glu Asn Cys Lys Leu Pro
Arg Trp His Met Asn Asp Phe 900 905 910Phe His Ser Phe Leu Ile Val
Phe Arg Val Leu Cys Gly Glu Trp Ile 915 920 925Glu Thr Met Trp Asp
Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 930 935 940Ile Val Tyr
Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn945 950 955
960Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu
Thr 965 970 975Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile
Ala Val Ala 980 985 990Arg Ile Lys Arg Gly Ile Asn Tyr Val Lys Gln
Thr Leu Arg Glu Phe 995 1000 1005Ile Leu Lys Ser Phe Ser Lys Lys
Pro Lys Gly Ser Lys Asp Thr 1010 1015 1020Lys Arg Thr Ala Asp Pro
Asn Asn Lys Arg Glu Asn Tyr Ile Ser 1025 1030 1035Asn Arg Thr Leu
Ala Glu Ile Ser Lys Asp His Asn Phe Leu Lys 1040 1045 1050Glu Lys
Asp Lys Ile Ser Gly Phe Ser Ser Ser Leu Asp Lys Ser 1055 1060
1065Phe Met Asp Glu Asn Asp Tyr Gln Ser Phe Ile His Asn Pro Ser
1070 1075 1080Leu Thr Val Thr Val Pro Ile Ala Pro Gly Glu Ser Asp
Leu Glu 1085 1090 1095Asn Met Asn Thr Glu Glu Leu Ser Ser Asp Ser
Asp Ser Asp Tyr 1100 1105 1110Ser Lys Glu Arg Arg Asn Arg Ser Ser
Ser Ser Glu Cys Ser Thr 1115 1120 1125Val Asp Asn Pro Leu Pro Gly
Glu Glu Glu Ala Glu Ala Glu Pro 1130 1135 1140Ile Asn Ala Asp Glu
Pro Glu Ala Cys Phe Thr Asp Gly Cys Val 1145 1150 1155Arg Arg Phe
Pro Cys Cys Gln Val Asn Ile Asp Ser Gly Lys Gly 1160 1165 1170Lys
Val Trp Trp Thr Ile Arg Lys Thr Cys Tyr Arg Ile Val Glu 1175 1180
1185His Ser Trp Phe Glu Ser Phe Ile Val Leu Met Ile Leu Leu Ser
1190 1195 1200Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu Lys
Lys Lys 1205 1210 1215Thr Ile Lys Ile Ile Leu Glu Tyr Ala Asp Lys
Ile Phe Thr Tyr 1220 1225 1230Ile Phe Ile Leu Glu Met Leu Leu Lys
Trp Val Ala Tyr Gly Tyr 1235 1240 1245Lys Thr Tyr Phe Thr Asn Ala
Trp Cys Trp Leu Asp Phe Leu Ile 1250 1255 1260Val Asp Val Ser Leu
Val Thr Leu Val Ala Asn Thr Leu Gly Tyr 1265 1270 1275Ser Asp Leu
Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu 1280 1285 1290Arg
Pro Leu Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val 1295 1300
1305Val Asn Ala Leu Ile Gly Ala Ile Pro Ser Ile Met Asn Val Leu
1310 1315 1320Leu Val Cys Leu Ile Phe Trp Leu Ile Phe Ser Ile Met
Gly Val 1325 1330 1335Asn Leu Phe Ala Gly Lys Phe Tyr Glu Cys Val
Asn Thr Thr Asp 1340 1345 1350Gly Ser Arg Phe Ser Val Ser Gln Val
Ala Asn Arg Ser Glu Cys 1355 1360 1365Phe Ala Leu Met Asn Val Ser
Gly Asn Val Arg Trp Lys Asn Leu 1370 1375 1380Lys Val Asn Phe Asp
Asn Val Gly Leu Gly Tyr Leu Ser Leu Leu 1385 1390 1395Gln Val Ala
Thr Phe Lys Gly Trp Met Asp Ile Met Tyr Ala Ala 1400 1405 1410Val
Asp Ser Val Asn Val Asn Ala Gln Pro Ile Tyr Glu Tyr Asn 1415 1420
1425Leu Tyr Met Tyr Ile Tyr Phe Val Ile Phe Ile Ile Phe Gly Ser
1430 1435 1440Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp
Asn Phe 1445 1450 1455Asn Gln Gln Lys Lys Lys Leu Gly Gly Gln Asp
Ile Phe Met Thr 1460 1465 1470Glu Glu Gln Lys Lys Tyr Tyr Asn Ala
Met Lys Lys Leu Gly Ser 1475 1480 1485Lys Lys Pro Gln Lys Pro Ile
Pro Arg Pro Gly Asn Lys Phe Gln 1490 1495 1500Gly Cys Ile Phe Asp
Leu Val Thr Asn Gln Ala Phe Asp Ile Thr 1505 1510 1515Ile Met Val
Leu Ile Cys Leu Asn Met Val Thr Met Met Val Glu 1520 1525 1530Lys
Glu Gly Gln Thr Asp Tyr Met Ser Phe Val Leu Tyr Trp Ile 1535 1540
1545Asn Val Val Phe Ile Ile Leu Phe Thr Gly Glu Cys Val Leu Lys
1550 1555 1560Leu Ile Ser Leu Arg His Tyr Tyr Phe Thr Val Gly Trp
Asn Ile 1565 1570 1575Phe Asp Phe Val Val Val Ile Leu Ser Ile Val
Gly Met Phe Leu 1580 1585 1590Ala Glu Met Ile Glu Lys Tyr Phe Val
Ser Pro Thr Leu Phe Arg 1595 1600 1605Val Ile Arg Leu Ala Arg Ile
Gly Arg Ile Leu Arg Leu Ile Lys 1610 1615 1620Gly Ala Lys Gly Ile
Arg Thr Leu Leu Phe Ala Leu Met Met Ser 1625 1630 1635Leu Pro Ala
Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu Val Met 1640 1645 1650Phe
Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe Ala Tyr Val Lys 1655 1660
1665Lys Glu Ala Gly Ile Asn Asp Met Phe Asn Phe Glu Thr Phe Gly
1670 1675 1680Asn Ser Met Ile Cys Leu Phe Gln Ile Thr Thr Ser Ala
Gly Trp 1685 1690 1695Asp Gly Leu Leu Ala Pro Ile Leu Asn Ser Ala
Pro Pro Asp Cys 1700 1705 1710Asp Pro Lys Lys Val His Pro Gly Ser
Ser Val Glu Gly Asp Cys 1715 1720 1725Gly Asn Pro Ser Val Gly Ile
Phe Tyr Phe Val Ser Tyr Ile Ile 1730 1735 1740Ile Ser Phe Leu Val
Val Val Asn Met Tyr Ile Ala Val Ile Leu 1745 1750 1755Glu Asn Phe
Ser Val Ala Thr Glu Glu Ser Thr Glu Pro Leu Ser 1760 1765 1770Glu
Asp Asp Phe Glu Met Phe Tyr Glu Val Trp Glu Lys Phe Asp 1775 1780
1785Pro Asp Ala Thr Gln Phe Ile Glu Phe Cys Lys Leu Ser Asp Phe
1790 1795 1800Ala Ala Ala Leu Asp Pro Pro Leu Leu Ile Ala Lys Pro
Asn Lys 1805 1810 1815Val Gln Leu Ile Ala Met Asp Leu Pro Met Val
Ser Gly Asp Arg 1820 1825 1830Ile His Cys Leu Asp Ile Leu Phe Ala
Phe Thr Lys Arg Val Leu 1835 1840 1845Gly Glu Ser Gly Glu Met Asp
Ser Leu Arg Ser Gln Met Glu Glu 1850 1855 1860Arg Phe Met Ser Ala
Asn Pro Ser Lys Val Ser Tyr Glu Pro Ile 1865 1870 1875Thr Thr Thr
Leu Lys Arg Lys Gln Glu Asp Val Ser Ala Thr Ile 1880 1885 1890Ile
Gln Arg Ala Tyr Arg Arg Tyr Arg Leu Arg Gln Asn Val Lys 1895 1900
1905Asn Ile Ser Ser Ile Tyr Ile Lys Asp Gly Asp Arg Asp Asp Asp
1910 1915 1920Leu Pro Asn Lys Glu Asp Ile Val Phe Asp Asn Val Asn
Glu Asn 1925 1930 1935Ser Ser Pro Glu Lys Thr Asp Ala Thr Ala Ser
Thr Ile Ser Pro 1940 1945 1950Pro Ser Tyr Asp Ser Val Thr Lys Pro
Asp Gln Glu Lys Tyr Glu 1955 1960 1965Thr Asp Lys Thr Glu Lys Glu
Asp Lys Glu Lys Asp Glu Ser Arg 1970 1975 1980Lys179265DNAMus
musculus 17tacaggatga gaagatggcg atgttgcctc cgccaggacc tcagagcttc
gttcacttca 60caaaacagtc ccttgccctc attgaacaac gcatttctga agaaaaagcc
aagggacaca 120aagatgaaaa gaaagatgat gaggaagaag gtcccaagcc
cagtagtgac ttggaagcag 180gtaaacagct acccttcatc tacggagaca
ttcccccggg aatggtgtca gagcccctgg 240aggacctgga cccatactat
gcagacaaaa aaacttttat agtattgaac aaagggaaag 300caatcttccg
tttcaacgcc acccctgctt tgtacatgct gtctcccttc agtcctctca
360gaagaatatc tattaagatt ttagtgcact ccttattcag catgctaatc
atgtgcacaa 420ttctgacaaa ctgcatattc atgaccatga gcaaccctcc
agattggacc aaaaacgtag 480agtacacttt tactgggata tatacttttg
aatcactcat aaaaatcctt gcaagaggct 540tttgcgtggg cgaattcacc
ttcctccgtg acccttggaa ctggctggac tttgttgtca 600ttgtttttgc
atatgtgaca gagtttgtgg acctgggcaa tgtctcagcg ttgagaacat
660tcagagttct ccgagcattg aaaacaatat cagtcattcc aggactaaaa
accatcgtgg 720gggccctgat ccaatcagtg aagaagctct ctgacgtcat
gatcctcact gtgttctgtc 780tcagtgtgtt cgcactaatt ggactacaac
tgtttatggg caacttgaag cataaatgtt 840tccggaagga ccttgagcag
aatgaaacat tagaaagcat catgagtact gctgagagtg 900aagaagaatt
gaaaagatat ttttattact tggagggatc caaagatgct cttctttgcg
960gtttcagcac agattcaggg cagtgtcctg aagggtacga gtgtgtgaca
gctggcagaa 1020acccagatta tggctacaca agctttgaca cgttcggctg
ggccttcttg gccttgtttc 1080ggctaatgac tcaggactac tgggagaacc
tttatcaaca gacactgcgt gctgctggca 1140aaacctacat gattttcttt
gtcgtggtga tatttctggg atccttttac ctgataaact 1200tgatcctggc
tgtggtagcc atggcgtacg aggaacagaa ccaggccaac atcgaagaag
1260ctaaacagaa agagttagaa tttcagcaga tgttagaccg actcaaaaaa
gagcaggaag 1320aagccgaggc gatcgctgca gccgctgctg agtacacgag
tttagggcgg agcaggatta 1380tgggactctc tgagagctct tcagaaacct
ccaggctgag ctcaaagagt gccaaggaga 1440gaagaaaccg aagaaagaaa
aaaaaacaga agctgtccag tggcgaggaa aagggtgatg 1500atgagaagct
gtccaagtca gggtcagagg aaagcatccg aaagaaaagc ttccatctcg
1560gcgtggaagg gcaccaccgg gccagggaaa agaggctgtc cacccccaac
cagtcaccac 1620tcagcattcg tgggtccttg ttttctgcca ggcgcagcag
cagaacaagt ctcttcagtt 1680ttaaggggcg aggaagagat ctgggatctg
aaacggaatt tgctgatgat gagcatagca 1740tttttggaga caacgagagc
agaaggggtt cactatttgt accccataga ccccgggagc 1800ggcgcagcag
taacatcagc caggccagta ggtccccacc agtgctgccg gtgaacggga
1860agatgcacag tgcagtggac tgcaatggcg tggtgtcgct tgttgatgga
ccctcagccc 1920tcatgctccc caatggacag cttcttccag agggcacaac
taatcagatg cgtaaaaaaa 1980ggctctctag ttcttacttt ttgtctgagg
acatgctgaa tgacccacat ctcaggcaaa 2040gggccatgag cagagcaagc
attctaacca acacagtaga agaacttgaa gaatctagac 2100aaaaatgtcc
accatggtgg tacagatttg ctcacacatt tttaatctgg aattgttctc
2160catattggat aaaattcaaa aagttcatct attttattgt aatggatcct
tttgtagatc 2220ttgcaattac catttgcata gttttaaaca ccttgtttat
ggctatggag caccatccaa 2280tgacggatga attcaaaaat gtacttgcag
tcgggaacct ggtcttcaca gggatcttcg 2340cagctgaaat ggtactgaag
ttaatagcca tggatcccta tgaatatttc caagtagggt 2400ggaatatttt
tgacagcctg attgtgacgt tgagtttggt ggagcttttc ctagcagatg
2460tggaaggatt atcagtcctg cggtccttta gattgctgcg agtcttcaag
ttggcaaaat 2520cctggcccac actgaatatg ctcattaaga tcatcggcaa
ctcggtgggc gcactgggca 2580acctgaccct ggtgctggcc atcatcgtct
tcatttttgc cgtggtcggc atgcagctgt 2640ttggaaagag ctacaaggag
tgtgtttgca agatcaacga gaactgcaag ctcccacgct 2700ggcacatgaa
cgacttcttc cactccttcc tgatcgtgtt ccgtgtgctg tgtggggagt
2760ggatagagac catgtgggac tgcatggagg ttgcgggcca gaccatgtgc
cttattgttt 2820acatgatggt catggtgatt gggaaccttg tggtcctgaa
cctgtttctg gctttattac 2880tgagttcctt tagttctgac aatcttacag
caattgaaga agacaccgac gcaaacaacc 2940tccagattgc agtggccaga
attaaaagag ggatcaatta tgtgaaacag accctgcgtg 3000aattcattct
aaagtcattt tccaaaaagc caaagggctc caaggacaca aaacgaacag
3060cggatcccaa caacaaaaga gaaaactata tctcaaaccg tacccttgcg
gagataagca 3120aagatcacaa tttcctcaaa gaaaaggata agatcagtgg
ttttagcagc agtctagaca 3180aaagctttat ggatgaaaac gattaccagt
cctttattca taatcccagc ctcacagtga 3240cagtgcccat tgcacctggg
gagtctgatt tggagaatat gaacacagaa gagcttagca 3300gtgactcaga
tagtgactac agcaaagaga gacggaaccg atcaagttct tcagagtgca
3360gcacagttga taaccctctg ccaggagaag aggaggcaga agctgagcct
atcaatgcag 3420atgagcccga agcctgtttt acagatggct gtgtgaggag
atttccatgc tgccaagtta 3480acatagactc cgggaaaggg aaagtttggt
ggaccatccg gaagacctgc tacaggatag 3540tggagcacag ctggtttgaa
agcttcattg ttctcatgat cctgctcagc agtggagctc 3600tggcttttga
ggatatatat attgaaaaga aaaagaccat taagattatc ctggagtatg
3660ctgacaagat attcacctac atcttcattc tggaaatgct tctaaaatgg
gtggcatacg 3720ggtataaaac atatttcact aatgcctggt gttggctgga
cttcttaatt gttgatgtgt 3780ctctagttac tttagtagcc aacactcttg
gctactcaga ccttggcccc attaaatctc 3840tacggacact gagggcccta
agacccctaa gagctttgtc tagatttgaa ggaatgaggg 3900tagtggtcaa
cgcactcata ggagcaatcc cttccatcat gaatgtgctt cttgtgtgcc
3960ttatattctg gctaatattt agcatcatgg gagtcaatct gtttgctggc
aagttctatg 4020agtgtgttaa caccacagat ggctcacgat tttctgtatc
tcaagttgca aaccgttctg 4080agtgttttgc cctgatgaat gttagtggaa
atgtgcgatg gaaaaacctg aaagtaaact 4140tcgataacgt tggacttggt
tacctgtcgc tgcttcaagt tgcaacgttc aagggctgga 4200tggatattat
gtatgcagca gttgactctg ttaatgtaaa tgcacaacca atatatgaat
4260acaacctcta catgtacatt tattttgtca tcttcatcat ctttggctca
ttcttcactt 4320tgaacttgtt cattggtgtc atcatcgata atttcaacca
acagaagaag aagcttggag 4380gtcaagatat ctttatgaca gaagaacaga
agaaatacta taatgcaatg aagaagctgg 4440ggtccaagaa accacaaaaa
ccaattccga ggccagggaa caaattccaa ggatgcatat 4500ttgacttagt
gacaaaccaa gcttttgata tcaccatcat ggttcttatc tgcctcaata
4560tggtaaccat gatggtagaa aaagaggggc aaactgacta catgagtttt
gtgctatact 4620ggatcaacgt ggtcttcatc atcctgttca ctggggagtg
tgtgctgaag ctgatctctc 4680tcaggcatta ctacttcact gtgggatgga
acatttttga ttttgtggta gtgatcctct 4740ccattgtagg aatgtttctc
gctgagatga tagagaagta tttcgtgtct cctaccctgt 4800tccgagtcat
tcgcctggcc aggattggac gaatcctacg cctgatcaaa ggcgccaagg
4860ggatccgcac gctgctcttt gctctgatga tgtcccttcc tgcgctgttc
aacatcggcc 4920tcctgctttt cctcgtcatg ttcatctacg ccatctttgg
gatgtccaac tttgcctacg 4980ttaaaaagga agctggaatt aatgacatgt
tcaactttga gaccttcggc aacagcatga 5040tctgcctgtt ccaaatcacc
acctctgcgg gctgggatgg actgctggcc cccatcctca 5100acagtgcacc
tcctgactgt gacccaaaaa aggttcaccc aggaagttca gtggaagggg
5160actgtggaaa tccatctgtg ggaattttct actttgtcag ctacatcatc
atatccttcc 5220tggttgtggt gaacatgtac attgctgtca tcctggagaa
cttcagcgtt gccacagaag 5280aaagtactga gcccctgagt gaggacgact
ttgagatgtt ctacgaagtc tgggagaagt 5340tcgaccctga cgccacccag
ttcatagagt tctgcaagct ctctgacttt gcagcagccc 5400tggatcctcc
cctcctcatc gcaaagccaa acaaagtcca gctcattgcc atggacctgc
5460ccatggtgag tggagaccgc atccactgcc tggacatctt atttgctttt
acaaagcggg 5520tcctgggcga gagcggagag atggattccc ttcgttcaca
gatggaagaa aggtttatgt 5580cagccaatcc ttctaaagtg tcctatgagc
ccatcacaac cacactgaag cgaaaacaag 5640aggatgtatc tgcgactatc
attcagcgtg cttacagacg gtaccgcctt aggcaaaacg 5700tcaagaatat
atcaagtata tatataaaag atggagacag agatgacgat ttgcccaata
5760aagaagatat agtttttgat aatgttaacg agaactcaag tccagaaaag
acagatgcaa 5820cagcctctac catctctcca ccttcctatg acagtgtcac
aaagccagat caagagaaat 5880atgaaacaga caaaacggag aaggaagaca
aagagaaaga cgaaagcagg aaatagagct 5940tcggttttga tacactgttt
acagcctgcg aaggtgactc actcgtgtta ataagactct 6000tttacggagg
tctatgccaa actcttttta tcaaatattc tcaaaggcag cacagccact
6060agctctgatc cagtgaaaca agagagaagc atttacacat ggctactttt
tgcgttggtc 6120aatgattctt taagaattgt gcatgtaact ctacagggaa
taatcattat tgcaatcaag 6180ggtgacttaa tgattttaaa tatcagaaaa
ccacatagaa cattttctct tttgcctcca 6240tttctttccc tagattctaa
gtagatgtgt acccatgtga atatagaaat tcaggcgcac 6300atgctcacag
tcacaaacac aaacaggatt agctgtgatt tggaattcga tgtaaatatt
6360tcacctgtga tttgcaatga aattccttgt aaaagaaatg cgaattagtg
atgaaggttt 6420tgtgaaaaca tcttatcatt agggagtcag aatttctgtc
cataaagaat tcagtttata 6480ttttgaggtg ctgaaactta tcctacattg
catcaaaatc aatttatagg tatctgtaaa 6540atgtcatggg actgaaaaac
atatataggc tacttgttta agaaatggct ttcattcata 6600tagataggca
ttcaccttga tttatggaca tctttggcat tttgtgatca catgattctt
6660ccacaaaatt gcttagctgg aacttcaggc acacatcaca gagaacagct
acccagtctt 6720atgcccctct ctgtttgtac aataatcaca gagcttgaaa
cattatttga actataaata 6780tcaggtttct ccacatagac atatgaatat
tgttaacaga aaaaaatttt atttacagcg 6840ttttatttac taatatttat
ccaatctagt ttgcccaatg agacagctca tgactcacat 6900ctgaaagcca
gttgccacat ttatcttctt atgtaacttt ggtttgtcat actttatgtc
6960taagcaaatt gaatgtctcc tttctaatga gatgtaccct gaaatgcagt
taggtacttg 7020atactttagc gcttgtttga gcagatgact ggagcacagt
gtggactgca tctcttaaat 7080acaatcctta atgtgtttgg cagcttctca
ggttacaagg aacacccggc ttttagtgtc 7140tatctgttca ccaggtgttt
agtatgaatg aaacggcatt caaagagtga gtctcactgg 7200cttgctttat
tactgatgcc ttccctatgg agaattaatc ctctgaagcc ccattatgtc
7260cccctgtaaa taatgtagat gtcacttcct tcttaatatt ctaatccata
ctgtgaaatc 7320gattttgcat ttatcggtca aatagagcat tttgagatag
ttggagttac cctgccaagg 7380attagaaatc tacttcatgt ttttaaagta
cttgttaaaa atgaacgacc ctggcacatt 7440ctctcataat tttattccag
ccatgtgaaa tctttcttct aaacacttta tccttgcgga 7500ggaaaaaaaa
aatgagctga tgagccattt aagcacaaag gggctttatt tagaagattc
7560caagggggaa ctttgaagta aatatataaa acatacttca tcaatttgcc
tataaaacta 7620aaagaggaac acaggaatat tgataaaata agtcattaaa
acacattctt tatttcttgc 7680ccagtttaaa agaaagaact aaacatccct
agagagagga agagacatag agagagagtg 7740actaatagaa agagggagag
aagaaacaag gcaccaagga caaaaagaga taattagaca 7800gaacttgtcc
aggttttcac actatgtgct ctgtccagta ccgtacacaa gaacctcttt
7860ccaaatattt gtcctaaggc tctaagaagt taagtacgag gctgaaggtt
gaatacaact 7920gtctttaatc attaacagtt tggggagcta cttttaaacg
tctatggaag atgccaagca 7980gtggtaagcc agacaataca gagcactgca
tatctgtcaa gcagctgaaa tatgtttggg 8040caacttaatg gtgagccaca
caaaacatcc atttgtaaca attttaatac attcaattaa 8100gaaaccagga
tttttattat tttgcaccca taaaaatata actatattgt tcatttttat
8160tgatagagta tgtgtgaatc ttattgatta tctgtaattt actattaatg
tttttacagt 8220gactgttttt tttgtgtgtg taaacttaat atatgtcagc
aactggttcc tcaacacaat 8280tttttttagc attacaaaaa aatgaacagg
tataaaggtt ctcttttttc tacatcatgt 8340tgaacatatt ttgttctgaa
ttacatagtt ttaaatgtaa tattaagttt tatattcata 8400tatgtttaac
atcaaaatca ctacttatga cattgttatc aatttaaaaa atagtatttg
8460acactaggat agcatttaat taaagctaaa aagcttacac cccatttcat
gttgattagt 8520gtttggacta actctaaaat gtcatcaatg gaagctagtc
actgaaatta ttttatctat 8580tgtcatagaa tggtgactac ccaaaaaata
taagttagca ttaaatagaa gaaagcgtac 8640gtgaccacaa atccatgcac
agggttgtgt gaagacagga gaacctcatt tttctgtttt 8700gtctctttcc
actgtgtaaa aagtctacat ctgtgggcta tttctaaatt caaattgtca
8760caatttgcaa
tcataaatgt ttagcatact ttgtagaatt ttgatagttt tgtaaaagag
8820tgaaaaacaa atgcatatgt aaataaagca gcccatacta gcagattcct
caaatgttaa 8880tatgtaaata aagcagccct tactagcaga ttcatcaaat
gttaatatgt aaataaagca 8940gtccttatta gcagatttgt catatgttaa
ggggagtaat gataaggagg caactaaatc 9000aggatggtca gtaactgatc
tgggtttaga actgtgtttg gagccatcaa tttttaaata 9060tatgttctca
ctatgttatt agttgtctga agaagcaatc aagaattgct cccagaaaat
9120gagtaagtag ccatgaatat atgaatgctg tttacagaac ccatagacct
atgaatgctc 9180aaaatgtttg ggtttgtcaa aaaattacat tgtagttata
cttgatactt aaaaactgtt 9240aatagagtct aaaataaaag tcgct
9265181973PRTMus musculus 18Met Ala Met Leu Pro Pro Pro Gly Pro Gln
Ser Phe Val His Phe Thr1 5 10 15Lys Gln Ser Leu Ala Leu Ile Glu Gln
Arg Ile Ser Glu Glu Lys Ala 20 25 30Lys Gly His Lys Asp Glu Lys Lys
Asp Asp Glu Glu Glu Gly Pro Lys 35 40 45Pro Ser Ser Asp Leu Glu Ala
Gly Lys Gln Leu Pro Phe Ile Tyr Gly 50 55 60Asp Ile Pro Pro Gly Met
Val Ser Glu Pro Leu Glu Asp Leu Asp Pro65 70 75 80Tyr Tyr Ala Asp
Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 85 90 95Ile Phe Arg
Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 100 105 110Ser
Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 115 120
125Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr
130 135 140Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr
Phe Thr145 150 155 160Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile
Leu Ala Arg Gly Phe 165 170 175Cys Val Gly Glu Phe Thr Phe Leu Arg
Asp Pro Trp Asn Trp Leu Asp 180 185 190Phe Val Val Ile Val Phe Ala
Tyr Val Thr Glu Phe Val Asp Leu Gly 195 200 205Asn Val Ser Ala Leu
Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 210 215 220Ile Ser Val
Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln225 230 235
240Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu
245 250 255Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn
Leu Lys 260 265 270His Lys Cys Phe Arg Lys Asp Leu Glu Gln Asn Glu
Thr Leu Glu Ser 275 280 285Ile Met Ser Thr Ala Glu Ser Glu Glu Glu
Leu Lys Arg Tyr Phe Tyr 290 295 300Tyr Leu Glu Gly Ser Lys Asp Ala
Leu Leu Cys Gly Phe Ser Thr Asp305 310 315 320Ser Gly Gln Cys Pro
Glu Gly Tyr Glu Cys Val Thr Ala Gly Arg Asn 325 330 335Pro Asp Tyr
Gly Tyr Thr Ser Phe Asp Thr Phe Gly Trp Ala Phe Leu 340 345 350Ala
Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 355 360
365Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val
370 375 380Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu
Ala Val385 390 395 400Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala
Asn Ile Glu Glu Ala 405 410 415Lys Gln Lys Glu Leu Glu Phe Gln Gln
Met Leu Asp Arg Leu Lys Lys 420 425 430Glu Gln Glu Glu Ala Glu Ala
Ile Ala Ala Ala Ala Ala Glu Tyr Thr 435 440 445Ser Leu Gly Arg Ser
Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 450 455 460Thr Ser Arg
Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg465 470 475
480Lys Lys Lys Lys Gln Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Asp
485 490 495Glu Lys Leu Ser Lys Ser Gly Ser Glu Glu Ser Ile Arg Lys
Lys Ser 500 505 510Phe His Leu Gly Val Glu Gly His His Arg Ala Arg
Glu Lys Arg Leu 515 520 525Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile
Arg Gly Ser Leu Phe Ser 530 535 540Ala Arg Arg Ser Ser Arg Thr Ser
Leu Phe Ser Phe Lys Gly Arg Gly545 550 555 560Arg Asp Leu Gly Ser
Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 565 570 575Phe Gly Asp
Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 580 585 590Pro
Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 595 600
605Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn
610 615 620Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu
Pro Asn625 630 635 640Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln
Met Arg Lys Lys Arg 645 650 655Leu Ser Ser Ser Tyr Phe Leu Ser Glu
Asp Met Leu Asn Asp Pro His 660 665 670Leu Arg Gln Arg Ala Met Ser
Arg Ala Ser Ile Leu Thr Asn Thr Val 675 680 685Glu Glu Leu Glu Glu
Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg 690 695 700Phe Ala His
Thr Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys705 710 715
720Phe Lys Lys Phe Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu
725 730 735Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala
Met Glu 740 745 750His His Pro Met Thr Asp Glu Phe Lys Asn Val Leu
Ala Val Gly Asn 755 760 765Leu Val Phe Thr Gly Ile Phe Ala Ala Glu
Met Val Leu Lys Leu Ile 770 775 780Ala Met Asp Pro Tyr Glu Tyr Phe
Gln Val Gly Trp Asn Ile Phe Asp785 790 795 800Ser Leu Ile Val Thr
Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val 805 810 815Glu Gly Leu
Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys 820 825 830Leu
Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly 835 840
845Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile
850 855 860Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys
Ser Tyr865 870 875 880Lys Glu Cys Val Cys Lys Ile Asn Glu Asn Cys
Lys Leu Pro Arg Trp 885 890 895His Met Asn Asp Phe Phe His Ser Phe
Leu Ile Val Phe Arg Val Leu 900 905 910Cys Gly Glu Trp Ile Glu Thr
Met Trp Asp Cys Met Glu Val Ala Gly 915 920 925Gln Thr Met Cys Leu
Ile Val Tyr Met Met Val Met Val Ile Gly Asn 930 935 940Leu Val Val
Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser945 950 955
960Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu
965 970 975Gln Ile Ala Val Ala Arg Ile Lys Arg Gly Ile Asn Tyr Val
Lys Gln 980 985 990Thr Leu Arg Glu Phe Ile Leu Lys Ser Phe Ser Lys
Lys Pro Lys Gly 995 1000 1005Ser Lys Asp Thr Lys Arg Thr Ala Asp
Pro Asn Asn Lys Arg Glu 1010 1015 1020Asn Tyr Ile Ser Asn Arg Thr
Leu Ala Glu Ile Ser Lys Asp His 1025 1030 1035Asn Phe Leu Lys Glu
Lys Asp Lys Ile Ser Gly Phe Ser Ser Ser 1040 1045 1050Leu Asp Lys
Ser Phe Met Asp Glu Asn Asp Tyr Gln Ser Phe Ile 1055 1060 1065His
Asn Pro Ser Leu Thr Val Thr Val Pro Ile Ala Pro Gly Glu 1070 1075
1080Ser Asp Leu Glu Asn Met Asn Thr Glu Glu Leu Ser Ser Asp Ser
1085 1090 1095Asp Ser Asp Tyr Ser Lys Glu Arg Arg Asn Arg Ser Ser
Ser Ser 1100 1105 1110Glu Cys Ser Thr Val Asp Asn Pro Leu Pro Gly
Glu Glu Glu Ala 1115 1120 1125Glu Ala Glu Pro Ile Asn Ala Asp Glu
Pro Glu Ala Cys Phe Thr 1130 1135 1140Asp Gly Cys Val Arg Arg Phe
Pro Cys Cys Gln Val Asn Ile Asp 1145 1150 1155Ser Gly Lys Gly Lys
Val Trp Trp Thr Ile Arg Lys Thr Cys Tyr 1160 1165 1170Arg Ile Val
Glu His Ser Trp Phe Glu Ser Phe Ile Val Leu Met 1175 1180 1185Ile
Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile 1190 1195
1200Glu Lys Lys Lys Thr Ile Lys Ile Ile Leu Glu Tyr Ala Asp Lys
1205 1210 1215Ile Phe Thr Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys
Trp Val 1220 1225 1230Ala Tyr Gly Tyr Lys Thr Tyr Phe Thr Asn Ala
Trp Cys Trp Leu 1235 1240 1245Asp Phe Leu Ile Val Asp Val Ser Leu
Val Thr Leu Val Ala Asn 1250 1255 1260Thr Leu Gly Tyr Ser Asp Leu
Gly Pro Ile Lys Ser Leu Arg Thr 1265 1270 1275Leu Arg Ala Leu Arg
Pro Leu Arg Ala Leu Ser Arg Phe Glu Gly 1280 1285 1290Met Arg Val
Val Val Asn Ala Leu Ile Gly Ala Ile Pro Ser Ile 1295 1300 1305Met
Asn Val Leu Leu Val Cys Leu Ile Phe Trp Leu Ile Phe Ser 1310 1315
1320Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe Tyr Glu Cys Val
1325 1330 1335Asn Thr Thr Asp Gly Ser Arg Phe Ser Val Ser Gln Val
Ala Asn 1340 1345 1350Arg Ser Glu Cys Phe Ala Leu Met Asn Val Ser
Gly Asn Val Arg 1355 1360 1365Trp Lys Asn Leu Lys Val Asn Phe Asp
Asn Val Gly Leu Gly Tyr 1370 1375 1380Leu Ser Leu Leu Gln Val Ala
Thr Phe Lys Gly Trp Met Asp Ile 1385 1390 1395Met Tyr Ala Ala Val
Asp Ser Val Asn Val Asn Ala Gln Pro Ile 1400 1405 1410Tyr Glu Tyr
Asn Leu Tyr Met Tyr Ile Tyr Phe Val Ile Phe Ile 1415 1420 1425Ile
Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile 1430 1435
1440Ile Asp Asn Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly Gln Asp
1445 1450 1455Ile Phe Met Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala
Met Lys 1460 1465 1470Lys Leu Gly Ser Lys Lys Pro Gln Lys Pro Ile
Pro Arg Pro Gly 1475 1480 1485Asn Lys Phe Gln Gly Cys Ile Phe Asp
Leu Val Thr Asn Gln Ala 1490 1495 1500Phe Asp Ile Thr Ile Met Val
Leu Ile Cys Leu Asn Met Val Thr 1505 1510 1515Met Met Val Glu Lys
Glu Gly Gln Thr Asp Tyr Met Ser Phe Val 1520 1525 1530Leu Tyr Trp
Ile Asn Val Val Phe Ile Ile Leu Phe Thr Gly Glu 1535 1540 1545Cys
Val Leu Lys Leu Ile Ser Leu Arg His Tyr Tyr Phe Thr Val 1550 1555
1560Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile Leu Ser Ile Val
1565 1570 1575Gly Met Phe Leu Ala Glu Met Ile Glu Lys Tyr Phe Val
Ser Pro 1580 1585 1590Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile
Gly Arg Ile Leu 1595 1600 1605Arg Leu Ile Lys Gly Ala Lys Gly Ile
Arg Thr Leu Leu Phe Ala 1610 1615 1620Leu Met Met Ser Leu Pro Ala
Leu Phe Asn Ile Gly Leu Leu Leu 1625 1630 1635Phe Leu Val Met Phe
Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe 1640 1645 1650Ala Tyr Val
Lys Lys Glu Ala Gly Ile Asn Asp Met Phe Asn Phe 1655 1660 1665Glu
Thr Phe Gly Asn Ser Met Ile Cys Leu Phe Gln Ile Thr Thr 1670 1675
1680Ser Ala Gly Trp Asp Gly Leu Leu Ala Pro Ile Leu Asn Ser Ala
1685 1690 1695Pro Pro Asp Cys Asp Pro Lys Lys Val His Pro Gly Ser
Ser Val 1700 1705 1710Glu Gly Asp Cys Gly Asn Pro Ser Val Gly Ile
Phe Tyr Phe Val 1715 1720 1725Ser Tyr Ile Ile Ile Ser Phe Leu Val
Val Val Asn Met Tyr Ile 1730 1735 1740Ala Val Ile Leu Glu Asn Phe
Ser Val Ala Thr Glu Glu Ser Thr 1745 1750 1755Glu Pro Leu Ser Glu
Asp Asp Phe Glu Met Phe Tyr Glu Val Trp 1760 1765 1770Glu Lys Phe
Asp Pro Asp Ala Thr Gln Phe Ile Glu Phe Cys Lys 1775 1780 1785Leu
Ser Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu Leu Ile Ala 1790 1795
1800Lys Pro Asn Lys Val Gln Leu Ile Ala Met Asp Leu Pro Met Val
1805 1810 1815Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu Phe Ala
Phe Thr 1820 1825 1830Lys Arg Val Leu Gly Glu Ser Gly Glu Met Asp
Ser Leu Arg Ser 1835 1840 1845Gln Met Glu Glu Arg Phe Met Ser Ala
Asn Pro Ser Lys Val Ser 1850 1855 1860Tyr Glu Pro Ile Thr Thr Thr
Leu Lys Arg Lys Gln Glu Asp Val 1865 1870 1875Ser Ala Thr Ile Ile
Gln Arg Ala Tyr Arg Arg Tyr Arg Leu Arg 1880 1885 1890Gln Asn Val
Lys Asn Ile Ser Ser Ile Tyr Ile Lys Asp Gly Asp 1895 1900 1905Arg
Asp Asp Asp Leu Pro Asn Lys Glu Asp Ile Val Phe Asp Asn 1910 1915
1920Val Asn Glu Asn Ser Ser Pro Glu Lys Thr Asp Ala Thr Ala Ser
1925 1930 1935Thr Ile Ser Pro Pro Ser Tyr Asp Ser Val Thr Lys Pro
Asp Gln 1940 1945 1950Glu Lys Tyr Glu Thr Asp Lys Thr Glu Lys Glu
Asp Lys Glu Lys 1955 1960 1965Asp Glu Ser Arg Lys 1970199265DNAMus
musculus 19tacaggatga gaagatggcg atgttgcctc cgccaggacc tcagagcttc
gttcacttca 60caaaacagtc ccttgccctc attgaacaac gcatttctga agaaaaagcc
aagggacaca 120aagatgaaaa gaaagatgat gaggaagaag gtcccaagcc
cagtagtgac ttggaagcag 180gtaaacagct acccttcatc tacggagaca
ttcccccggg aatggtgtca gagcccctgg 240aggacctgga cccatactat
gcagacaaaa aaacttttat agtattgaac aaagggaaag 300caatcttccg
tttcaacgcc acccctgctt tgtacatgct gtctcccttc agtcctctca
360gaagaatatc tattaagatt ttagtgcact ccttattcag catgctaatc
atgtgcacaa 420ttctgacaaa ctgcatattc atgaccatga gcaaccctcc
agattggacc aaaaacgtag 480agtacacttt tactgggata tatacttttg
aatcactcat aaaaatcctt gcaagaggct 540tttgcgtggg cgaattcacc
ttcctccgtg acccttggaa ctggctggac tttgttgtca 600ttgtttttgc
gtatttaaca gaatttgtaa acctaggcaa tgtttcagct cttcgaactt
660tcagagtctt gagagctttg aaaactattt ctgtaattcc aggactaaaa
accatcgtgg 720gggccctgat ccaatcagtg aagaagctct ctgacgtcat
gatcctcact gtgttctgtc 780tcagtgtgtt cgcactaatt ggactacaac
tgtttatggg caacttgaag cataaatgtt 840tccggaagga ccttgagcag
aatgaaacat tagaaagcat catgagtact gctgagagtg 900aagaagaatt
gaaaagatat ttttattact tggagggatc caaagatgct cttctttgcg
960gtttcagcac agattcaggg cagtgtcctg aagggtacga gtgtgtgaca
gctggcagaa 1020acccagatta tggctacaca agctttgaca cgttcggctg
ggccttcttg gccttgtttc 1080ggctaatgac tcaggactac tgggagaacc
tttatcaaca gacactgcgt gctgctggca 1140aaacctacat gattttcttt
gtcgtggtga tatttctggg atccttttac ctgataaact 1200tgatcctggc
tgtggtagcc atggcgtacg aggaacagaa ccaggccaac atcgaagaag
1260ctaaacagaa agagttagaa tttcagcaga tgttagaccg actcaaaaaa
gagcaggaag 1320aagccgaggc gatcgctgca gccgctgctg agtacacgag
tttagggcgg agcaggatta 1380tgggactctc tgagagctct tcagaaacct
ccaggctgag ctcaaagagt gccaaggaga 1440gaagaaaccg aagaaagaaa
aaaaaacaga agctgtccag tggcgaggaa aagggtgatg 1500atgagaagct
gtccaagtca gggtcagagg aaagcatccg aaagaaaagc ttccatctcg
1560gcgtggaagg gcaccaccgg gccagggaaa agaggctgtc cacccccaac
cagtcaccac 1620tcagcattcg tgggtccttg ttttctgcca ggcgcagcag
cagaacaagt ctcttcagtt 1680ttaaggggcg aggaagagat ctgggatctg
aaacggaatt tgctgatgat gagcatagca 1740tttttggaga caacgagagc
agaaggggtt cactatttgt accccataga ccccgggagc 1800ggcgcagcag
taacatcagc caggccagta ggtccccacc agtgctgccg gtgaacggga
1860agatgcacag tgcagtggac tgcaatggcg tggtgtcgct tgttgatgga
ccctcagccc 1920tcatgctccc caatggacag cttcttccag agggcacaac
taatcagatg cgtaaaaaaa 1980ggctctctag ttcttacttt ttgtctgagg
acatgctgaa tgacccacat ctcaggcaaa 2040gggccatgag cagagcaagc
attctaacca acacagtaga agaacttgaa gaatctagac 2100aaaaatgtcc
accatggtgg tacagatttg ctcacacatt tttaatctgg aattgttctc
2160catattggat aaaattcaaa aagttcatct attttattgt aatggatcct
tttgtagatc 2220ttgcaattac catttgcata gttttaaaca ccttgtttat
ggctatggag caccatccaa 2280tgacggatga attcaaaaat gtacttgcag
tcgggaacct ggtcttcaca gggatcttcg 2340cagctgaaat ggtactgaag
ttaatagcca tggatcccta tgaatatttc
caagtagggt 2400ggaatatttt tgacagcctg attgtgacgt tgagtttggt
ggagcttttc ctagcagatg 2460tggaaggatt atcagtcctg cggtccttta
gattgctgcg agtcttcaag ttggcaaaat 2520cctggcccac actgaatatg
ctcattaaga tcatcggcaa ctcggtgggc gcactgggca 2580acctgaccct
ggtgctggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctgt
2640ttggaaagag ctacaaggag tgtgtttgca agatcaacga gaactgcaag
ctcccacgct 2700ggcacatgaa cgacttcttc cactccttcc tgatcgtgtt
ccgtgtgctg tgtggggagt 2760ggatagagac catgtgggac tgcatggagg
ttgcgggcca gaccatgtgc cttattgttt 2820acatgatggt catggtgatt
gggaaccttg tggtcctgaa cctgtttctg gctttattac 2880tgagttcctt
tagttctgac aatcttacag caattgaaga agacaccgac gcaaacaacc
2940tccagattgc agtggccaga attaaaagag ggatcaatta tgtgaaacag
accctgcgtg 3000aattcattct aaagtcattt tccaaaaagc caaagggctc
caaggacaca aaacgaacag 3060cggatcccaa caacaaaaga gaaaactata
tctcaaaccg tacccttgcg gagataagca 3120aagatcacaa tttcctcaaa
gaaaaggata agatcagtgg ttttagcagc agtctagaca 3180aaagctttat
ggatgaaaac gattaccagt cctttattca taatcccagc ctcacagtga
3240cagtgcccat tgcacctggg gagtctgatt tggagaatat gaacacagaa
gagcttagca 3300gtgactcaga tagtgactac agcaaagaga gacggaaccg
atcaagttct tcagagtgca 3360gcacagttga taaccctctg ccaggagaag
aggaggcaga agctgagcct atcaatgcag 3420atgagcccga agcctgtttt
acagatggct gtgtgaggag atttccatgc tgccaagtta 3480acatagactc
cgggaaaggg aaagtttggt ggaccatccg gaagacctgc tacaggatag
3540tggagcacag ctggtttgaa agcttcattg ttctcatgat cctgctcagc
agtggagctc 3600tggcttttga ggatatatat attgaaaaga aaaagaccat
taagattatc ctggagtatg 3660ctgacaagat attcacctac atcttcattc
tggaaatgct tctaaaatgg gtggcatacg 3720ggtataaaac atatttcact
aatgcctggt gttggctgga cttcttaatt gttgatgtgt 3780ctctagttac
tttagtagcc aacactcttg gctactcaga ccttggcccc attaaatctc
3840tacggacact gagggcccta agacccctaa gagctttgtc tagatttgaa
ggaatgaggg 3900tagtggtcaa cgcactcata ggagcaatcc cttccatcat
gaatgtgctt cttgtgtgcc 3960ttatattctg gctaatattt agcatcatgg
gagtcaatct gtttgctggc aagttctatg 4020agtgtgttaa caccacagat
ggctcacgat tttctgtatc tcaagttgca aaccgttctg 4080agtgttttgc
cctgatgaat gttagtggaa atgtgcgatg gaaaaacctg aaagtaaact
4140tcgataacgt tggacttggt tacctgtcgc tgcttcaagt tgcaacgttc
aagggctgga 4200tggatattat gtatgcagca gttgactctg ttaatgtaaa
tgcacaacca atatatgaat 4260acaacctcta catgtacatt tattttgtca
tcttcatcat ctttggctca ttcttcactt 4320tgaacttgtt cattggtgtc
atcatcgata atttcaacca acagaagaag aagcttggag 4380gtcaagatat
ctttatgaca gaagaacaga agaaatacta taatgcaatg aagaagctgg
4440ggtccaagaa accacaaaaa ccaattccga ggccagggaa caaattccaa
ggatgcatat 4500ttgacttagt gacaaaccaa gcttttgata tcaccatcat
ggttcttatc tgcctcaata 4560tggtaaccat gatggtagaa aaagaggggc
aaactgacta catgagtttt gtgctatact 4620ggatcaacgt ggtcttcatc
atcctgttca ctggggagtg tgtgctgaag ctgatctctc 4680tcaggcatta
ctacttcact gtgggatgga acatttttga ttttgtggta gtgatcctct
4740ccattgtagg aatgtttctc gctgagatga tagagaagta tttcgtgtct
cctaccctgt 4800tccgagtcat tcgcctggcc aggattggac gaatcctacg
cctgatcaaa ggcgccaagg 4860ggatccgcac gctgctcttt gctctgatga
tgtcccttcc tgcgctgttc aacatcggcc 4920tcctgctttt cctcgtcatg
ttcatctacg ccatctttgg gatgtccaac tttgcctacg 4980ttaaaaagga
agctggaatt aatgacatgt tcaactttga gaccttcggc aacagcatga
5040tctgcctgtt ccaaatcacc acctctgcgg gctgggatgg actgctggcc
cccatcctca 5100acagtgcacc tcctgactgt gacccaaaaa aggttcaccc
aggaagttca gtggaagggg 5160actgtggaaa tccatctgtg ggaattttct
actttgtcag ctacatcatc atatccttcc 5220tggttgtggt gaacatgtac
attgctgtca tcctggagaa cttcagcgtt gccacagaag 5280aaagtactga
gcccctgagt gaggacgact ttgagatgtt ctacgaagtc tgggagaagt
5340tcgaccctga cgccacccag ttcatagagt tctgcaagct ctctgacttt
gcagcagccc 5400tggatcctcc cctcctcatc gcaaagccaa acaaagtcca
gctcattgcc atggacctgc 5460ccatggtgag tggagaccgc atccactgcc
tggacatctt atttgctttt acaaagcggg 5520tcctgggcga gagcggagag
atggattccc ttcgttcaca gatggaagaa aggtttatgt 5580cagccaatcc
ttctaaagtg tcctatgagc ccatcacaac cacactgaag cgaaaacaag
5640aggatgtatc tgcgactatc attcagcgtg cttacagacg gtaccgcctt
aggcaaaacg 5700tcaagaatat atcaagtata tatataaaag atggagacag
agatgacgat ttgcccaata 5760aagaagatat agtttttgat aatgttaacg
agaactcaag tccagaaaag acagatgcaa 5820cagcctctac catctctcca
ccttcctatg acagtgtcac aaagccagat caagagaaat 5880atgaaacaga
caaaacggag aaggaagaca aagagaaaga cgaaagcagg aaatagagct
5940tcggttttga tacactgttt acagcctgcg aaggtgactc actcgtgtta
ataagactct 6000tttacggagg tctatgccaa actcttttta tcaaatattc
tcaaaggcag cacagccact 6060agctctgatc cagtgaaaca agagagaagc
atttacacat ggctactttt tgcgttggtc 6120aatgattctt taagaattgt
gcatgtaact ctacagggaa taatcattat tgcaatcaag 6180ggtgacttaa
tgattttaaa tatcagaaaa ccacatagaa cattttctct tttgcctcca
6240tttctttccc tagattctaa gtagatgtgt acccatgtga atatagaaat
tcaggcgcac 6300atgctcacag tcacaaacac aaacaggatt agctgtgatt
tggaattcga tgtaaatatt 6360tcacctgtga tttgcaatga aattccttgt
aaaagaaatg cgaattagtg atgaaggttt 6420tgtgaaaaca tcttatcatt
agggagtcag aatttctgtc cataaagaat tcagtttata 6480ttttgaggtg
ctgaaactta tcctacattg catcaaaatc aatttatagg tatctgtaaa
6540atgtcatggg actgaaaaac atatataggc tacttgttta agaaatggct
ttcattcata 6600tagataggca ttcaccttga tttatggaca tctttggcat
tttgtgatca catgattctt 6660ccacaaaatt gcttagctgg aacttcaggc
acacatcaca gagaacagct acccagtctt 6720atgcccctct ctgtttgtac
aataatcaca gagcttgaaa cattatttga actataaata 6780tcaggtttct
ccacatagac atatgaatat tgttaacaga aaaaaatttt atttacagcg
6840ttttatttac taatatttat ccaatctagt ttgcccaatg agacagctca
tgactcacat 6900ctgaaagcca gttgccacat ttatcttctt atgtaacttt
ggtttgtcat actttatgtc 6960taagcaaatt gaatgtctcc tttctaatga
gatgtaccct gaaatgcagt taggtacttg 7020atactttagc gcttgtttga
gcagatgact ggagcacagt gtggactgca tctcttaaat 7080acaatcctta
atgtgtttgg cagcttctca ggttacaagg aacacccggc ttttagtgtc
7140tatctgttca ccaggtgttt agtatgaatg aaacggcatt caaagagtga
gtctcactgg 7200cttgctttat tactgatgcc ttccctatgg agaattaatc
ctctgaagcc ccattatgtc 7260cccctgtaaa taatgtagat gtcacttcct
tcttaatatt ctaatccata ctgtgaaatc 7320gattttgcat ttatcggtca
aatagagcat tttgagatag ttggagttac cctgccaagg 7380attagaaatc
tacttcatgt ttttaaagta cttgttaaaa atgaacgacc ctggcacatt
7440ctctcataat tttattccag ccatgtgaaa tctttcttct aaacacttta
tccttgcgga 7500ggaaaaaaaa aatgagctga tgagccattt aagcacaaag
gggctttatt tagaagattc 7560caagggggaa ctttgaagta aatatataaa
acatacttca tcaatttgcc tataaaacta 7620aaagaggaac acaggaatat
tgataaaata agtcattaaa acacattctt tatttcttgc 7680ccagtttaaa
agaaagaact aaacatccct agagagagga agagacatag agagagagtg
7740actaatagaa agagggagag aagaaacaag gcaccaagga caaaaagaga
taattagaca 7800gaacttgtcc aggttttcac actatgtgct ctgtccagta
ccgtacacaa gaacctcttt 7860ccaaatattt gtcctaaggc tctaagaagt
taagtacgag gctgaaggtt gaatacaact 7920gtctttaatc attaacagtt
tggggagcta cttttaaacg tctatggaag atgccaagca 7980gtggtaagcc
agacaataca gagcactgca tatctgtcaa gcagctgaaa tatgtttggg
8040caacttaatg gtgagccaca caaaacatcc atttgtaaca attttaatac
attcaattaa 8100gaaaccagga tttttattat tttgcaccca taaaaatata
actatattgt tcatttttat 8160tgatagagta tgtgtgaatc ttattgatta
tctgtaattt actattaatg tttttacagt 8220gactgttttt tttgtgtgtg
taaacttaat atatgtcagc aactggttcc tcaacacaat 8280tttttttagc
attacaaaaa aatgaacagg tataaaggtt ctcttttttc tacatcatgt
8340tgaacatatt ttgttctgaa ttacatagtt ttaaatgtaa tattaagttt
tatattcata 8400tatgtttaac atcaaaatca ctacttatga cattgttatc
aatttaaaaa atagtatttg 8460acactaggat agcatttaat taaagctaaa
aagcttacac cccatttcat gttgattagt 8520gtttggacta actctaaaat
gtcatcaatg gaagctagtc actgaaatta ttttatctat 8580tgtcatagaa
tggtgactac ccaaaaaata taagttagca ttaaatagaa gaaagcgtac
8640gtgaccacaa atccatgcac agggttgtgt gaagacagga gaacctcatt
tttctgtttt 8700gtctctttcc actgtgtaaa aagtctacat ctgtgggcta
tttctaaatt caaattgtca 8760caatttgcaa tcataaatgt ttagcatact
ttgtagaatt ttgatagttt tgtaaaagag 8820tgaaaaacaa atgcatatgt
aaataaagca gcccatacta gcagattcct caaatgttaa 8880tatgtaaata
aagcagccct tactagcaga ttcatcaaat gttaatatgt aaataaagca
8940gtccttatta gcagatttgt catatgttaa ggggagtaat gataaggagg
caactaaatc 9000aggatggtca gtaactgatc tgggtttaga actgtgtttg
gagccatcaa tttttaaata 9060tatgttctca ctatgttatt agttgtctga
agaagcaatc aagaattgct cccagaaaat 9120gagtaagtag ccatgaatat
atgaatgctg tttacagaac ccatagacct atgaatgctc 9180aaaatgtttg
ggtttgtcaa aaaattacat tgtagttata cttgatactt aaaaactgtt
9240aatagagtct aaaataaaag tcgct 9265201973PRTMus musculus 20Met Ala
Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr1 5 10 15Lys
Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ser Glu Glu Lys Ala 20 25
30Lys Gly His Lys Asp Glu Lys Lys Asp Asp Glu Glu Glu Gly Pro Lys
35 40 45Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr
Gly 50 55 60Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu
Asp Pro65 70 75 80Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn
Lys Gly Lys Ala 85 90 95Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr
Met Leu Ser Pro Phe 100 105 110Ser Pro Leu Arg Arg Ile Ser Ile Lys
Ile Leu Val His Ser Leu Phe 115 120 125Ser Met Leu Ile Met Cys Thr
Ile Leu Thr Asn Cys Ile Phe Met Thr 130 135 140Met Ser Asn Pro Pro
Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr145 150 155 160Gly Ile
Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg Gly Phe 165 170
175Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp
180 185 190Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn
Leu Gly 195 200 205Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg
Ala Leu Lys Thr 210 215 220Ile Ser Val Ile Pro Gly Leu Lys Thr Ile
Val Gly Ala Leu Ile Gln225 230 235 240Ser Val Lys Lys Leu Ser Asp
Val Met Ile Leu Thr Val Phe Cys Leu 245 250 255Ser Val Phe Ala Leu
Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 260 265 270His Lys Cys
Phe Arg Lys Asp Leu Glu Gln Asn Glu Thr Leu Glu Ser 275 280 285Ile
Met Ser Thr Ala Glu Ser Glu Glu Glu Leu Lys Arg Tyr Phe Tyr 290 295
300Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr
Asp305 310 315 320Ser Gly Gln Cys Pro Glu Gly Tyr Glu Cys Val Thr
Ala Gly Arg Asn 325 330 335Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr
Phe Gly Trp Ala Phe Leu 340 345 350Ala Leu Phe Arg Leu Met Thr Gln
Asp Tyr Trp Glu Asn Leu Tyr Gln 355 360 365Gln Thr Leu Arg Ala Ala
Gly Lys Thr Tyr Met Ile Phe Phe Val Val 370 375 380Val Ile Phe Leu
Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val385 390 395 400Val
Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 405 410
415Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys
420 425 430Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu
Tyr Thr 435 440 445Ser Leu Gly Arg Ser Arg Ile Met Gly Leu Ser Glu
Ser Ser Ser Glu 450 455 460Thr Ser Arg Leu Ser Ser Lys Ser Ala Lys
Glu Arg Arg Asn Arg Arg465 470 475 480Lys Lys Lys Lys Gln Lys Leu
Ser Ser Gly Glu Glu Lys Gly Asp Asp 485 490 495Glu Lys Leu Ser Lys
Ser Gly Ser Glu Glu Ser Ile Arg Lys Lys Ser 500 505 510Phe His Leu
Gly Val Glu Gly His His Arg Ala Arg Glu Lys Arg Leu 515 520 525Ser
Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 530 535
540Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg
Gly545 550 555 560Arg Asp Leu Gly Ser Glu Thr Glu Phe Ala Asp Asp
Glu His Ser Ile 565 570 575Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser
Leu Phe Val Pro His Arg 580 585 590Pro Arg Glu Arg Arg Ser Ser Asn
Ile Ser Gln Ala Ser Arg Ser Pro 595 600 605Pro Val Leu Pro Val Asn
Gly Lys Met His Ser Ala Val Asp Cys Asn 610 615 620Gly Val Val Ser
Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn625 630 635 640Gly
Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Met Arg Lys Lys Arg 645 650
655Leu Ser Ser Ser Tyr Phe Leu Ser Glu Asp Met Leu Asn Asp Pro His
660 665 670Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn
Thr Val 675 680 685Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro
Trp Trp Tyr Arg 690 695 700Phe Ala His Thr Phe Leu Ile Trp Asn Cys
Ser Pro Tyr Trp Ile Lys705 710 715 720Phe Lys Lys Phe Ile Tyr Phe
Ile Val Met Asp Pro Phe Val Asp Leu 725 730 735Ala Ile Thr Ile Cys
Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu 740 745 750His His Pro
Met Thr Asp Glu Phe Lys Asn Val Leu Ala Val Gly Asn 755 760 765Leu
Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile 770 775
780Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe
Asp785 790 795 800Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe
Leu Ala Asp Val 805 810 815Glu Gly Leu Ser Val Leu Arg Ser Phe Arg
Leu Leu Arg Val Phe Lys 820 825 830Leu Ala Lys Ser Trp Pro Thr Leu
Asn Met Leu Ile Lys Ile Ile Gly 835 840 845Asn Ser Val Gly Ala Leu
Gly Asn Leu Thr Leu Val Leu Ala Ile Ile 850 855 860Val Phe Ile Phe
Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr865 870 875 880Lys
Glu Cys Val Cys Lys Ile Asn Glu Asn Cys Lys Leu Pro Arg Trp 885 890
895His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu
900 905 910Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val
Ala Gly 915 920 925Gln Thr Met Cys Leu Ile Val Tyr Met Met Val Met
Val Ile Gly Asn 930 935 940Leu Val Val Leu Asn Leu Phe Leu Ala Leu
Leu Leu Ser Ser Phe Ser945 950 955 960Ser Asp Asn Leu Thr Ala Ile
Glu Glu Asp Thr Asp Ala Asn Asn Leu 965 970 975Gln Ile Ala Val Ala
Arg Ile Lys Arg Gly Ile Asn Tyr Val Lys Gln 980 985 990Thr Leu Arg
Glu Phe Ile Leu Lys Ser Phe Ser Lys Lys Pro Lys Gly 995 1000
1005Ser Lys Asp Thr Lys Arg Thr Ala Asp Pro Asn Asn Lys Arg Glu
1010 1015 1020Asn Tyr Ile Ser Asn Arg Thr Leu Ala Glu Ile Ser Lys
Asp His 1025 1030 1035Asn Phe Leu Lys Glu Lys Asp Lys Ile Ser Gly
Phe Ser Ser Ser 1040 1045 1050Leu Asp Lys Ser Phe Met Asp Glu Asn
Asp Tyr Gln Ser Phe Ile 1055 1060 1065His Asn Pro Ser Leu Thr Val
Thr Val Pro Ile Ala Pro Gly Glu 1070 1075 1080Ser Asp Leu Glu Asn
Met Asn Thr Glu Glu Leu Ser Ser Asp Ser 1085 1090 1095Asp Ser Asp
Tyr Ser Lys Glu Arg Arg Asn Arg Ser Ser Ser Ser 1100 1105 1110Glu
Cys Ser Thr Val Asp Asn Pro Leu Pro Gly Glu Glu Glu Ala 1115 1120
1125Glu Ala Glu Pro Ile Asn Ala Asp Glu Pro Glu Ala Cys Phe Thr
1130 1135 1140Asp Gly Cys Val Arg Arg Phe Pro Cys Cys Gln Val Asn
Ile Asp 1145 1150 1155Ser Gly Lys Gly Lys Val Trp Trp Thr Ile Arg
Lys Thr Cys Tyr 1160 1165 1170Arg Ile Val Glu His Ser Trp Phe Glu
Ser Phe Ile Val Leu Met 1175 1180 1185Ile Leu Leu Ser Ser Gly Ala
Leu Ala Phe Glu Asp Ile Tyr Ile 1190 1195 1200Glu Lys Lys Lys Thr
Ile Lys Ile Ile Leu Glu Tyr Ala Asp Lys 1205 1210 1215Ile Phe Thr
Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val 1220 1225 1230Ala
Tyr Gly Tyr Lys Thr Tyr Phe Thr Asn Ala Trp Cys Trp Leu 1235 1240
1245Asp Phe Leu Ile Val Asp Val Ser Leu Val Thr Leu Val Ala Asn
1250 1255 1260Thr Leu Gly Tyr Ser Asp Leu Gly Pro Ile Lys Ser Leu
Arg Thr 1265 1270 1275Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser
Arg Phe Glu Gly 1280 1285 1290Met Arg Val Val Val Asn Ala Leu Ile
Gly Ala Ile Pro Ser Ile 1295 1300 1305Met Asn Val Leu Leu Val Cys
Leu Ile Phe Trp Leu Ile Phe Ser 1310 1315 1320Ile Met Gly Val Asn
Leu Phe Ala Gly Lys Phe Tyr Glu
Cys Val 1325 1330 1335Asn Thr Thr Asp Gly Ser Arg Phe Ser Val Ser
Gln Val Ala Asn 1340 1345 1350Arg Ser Glu Cys Phe Ala Leu Met Asn
Val Ser Gly Asn Val Arg 1355 1360 1365Trp Lys Asn Leu Lys Val Asn
Phe Asp Asn Val Gly Leu Gly Tyr 1370 1375 1380Leu Ser Leu Leu Gln
Val Ala Thr Phe Lys Gly Trp Met Asp Ile 1385 1390 1395Met Tyr Ala
Ala Val Asp Ser Val Asn Val Asn Ala Gln Pro Ile 1400 1405 1410Tyr
Glu Tyr Asn Leu Tyr Met Tyr Ile Tyr Phe Val Ile Phe Ile 1415 1420
1425Ile Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile
1430 1435 1440Ile Asp Asn Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly
Gln Asp 1445 1450 1455Ile Phe Met Thr Glu Glu Gln Lys Lys Tyr Tyr
Asn Ala Met Lys 1460 1465 1470Lys Leu Gly Ser Lys Lys Pro Gln Lys
Pro Ile Pro Arg Pro Gly 1475 1480 1485Asn Lys Phe Gln Gly Cys Ile
Phe Asp Leu Val Thr Asn Gln Ala 1490 1495 1500Phe Asp Ile Thr Ile
Met Val Leu Ile Cys Leu Asn Met Val Thr 1505 1510 1515Met Met Val
Glu Lys Glu Gly Gln Thr Asp Tyr Met Ser Phe Val 1520 1525 1530Leu
Tyr Trp Ile Asn Val Val Phe Ile Ile Leu Phe Thr Gly Glu 1535 1540
1545Cys Val Leu Lys Leu Ile Ser Leu Arg His Tyr Tyr Phe Thr Val
1550 1555 1560Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile Leu Ser
Ile Val 1565 1570 1575Gly Met Phe Leu Ala Glu Met Ile Glu Lys Tyr
Phe Val Ser Pro 1580 1585 1590Thr Leu Phe Arg Val Ile Arg Leu Ala
Arg Ile Gly Arg Ile Leu 1595 1600 1605Arg Leu Ile Lys Gly Ala Lys
Gly Ile Arg Thr Leu Leu Phe Ala 1610 1615 1620Leu Met Met Ser Leu
Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu 1625 1630 1635Phe Leu Val
Met Phe Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe 1640 1645 1650Ala
Tyr Val Lys Lys Glu Ala Gly Ile Asn Asp Met Phe Asn Phe 1655 1660
1665Glu Thr Phe Gly Asn Ser Met Ile Cys Leu Phe Gln Ile Thr Thr
1670 1675 1680Ser Ala Gly Trp Asp Gly Leu Leu Ala Pro Ile Leu Asn
Ser Ala 1685 1690 1695Pro Pro Asp Cys Asp Pro Lys Lys Val His Pro
Gly Ser Ser Val 1700 1705 1710Glu Gly Asp Cys Gly Asn Pro Ser Val
Gly Ile Phe Tyr Phe Val 1715 1720 1725Ser Tyr Ile Ile Ile Ser Phe
Leu Val Val Val Asn Met Tyr Ile 1730 1735 1740Ala Val Ile Leu Glu
Asn Phe Ser Val Ala Thr Glu Glu Ser Thr 1745 1750 1755Glu Pro Leu
Ser Glu Asp Asp Phe Glu Met Phe Tyr Glu Val Trp 1760 1765 1770Glu
Lys Phe Asp Pro Asp Ala Thr Gln Phe Ile Glu Phe Cys Lys 1775 1780
1785Leu Ser Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu Leu Ile Ala
1790 1795 1800Lys Pro Asn Lys Val Gln Leu Ile Ala Met Asp Leu Pro
Met Val 1805 1810 1815Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu
Phe Ala Phe Thr 1820 1825 1830Lys Arg Val Leu Gly Glu Ser Gly Glu
Met Asp Ser Leu Arg Ser 1835 1840 1845Gln Met Glu Glu Arg Phe Met
Ser Ala Asn Pro Ser Lys Val Ser 1850 1855 1860Tyr Glu Pro Ile Thr
Thr Thr Leu Lys Arg Lys Gln Glu Asp Val 1865 1870 1875Ser Ala Thr
Ile Ile Gln Arg Ala Tyr Arg Arg Tyr Arg Leu Arg 1880 1885 1890Gln
Asn Val Lys Asn Ile Ser Ser Ile Tyr Ile Lys Asp Gly Asp 1895 1900
1905Arg Asp Asp Asp Leu Pro Asn Lys Glu Asp Ile Val Phe Asp Asn
1910 1915 1920Val Asn Glu Asn Ser Ser Pro Glu Lys Thr Asp Ala Thr
Ala Ser 1925 1930 1935Thr Ile Ser Pro Pro Ser Tyr Asp Ser Val Thr
Lys Pro Asp Gln 1940 1945 1950Glu Lys Tyr Glu Thr Asp Lys Thr Glu
Lys Glu Asp Lys Glu Lys 1955 1960 1965Asp Glu Ser Arg Lys
19702160DNAHomo sapiens 21ttccaaatta caacctctgc tggctgggat
ggattgctag cacctattct taacagtaag 602220PRTHomo sapiens 22Phe Gln
Ile Thr Thr Ser Ala Gly Trp Asp Gly Leu Leu Ala Pro Ile1 5 10 15Leu
Asn Ser Lys 202360DNAHomo sapiens 23ttccaaatta caacctctgc
tggctgagat ggattgctag cacctattct taacagtaag 60248PRTHomo sapiens
24Phe Gln Ile Thr Thr Ser Ala Gly1 52560DNAHomo sapiens
25tcaggtcagt gtccagaggg gtacacctgt gtgaaaattg gcagaaaccc tgattatggc
602620PRTHomo sapiens 26Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val
Lys Ile Gly Arg Asn1 5 10 15Pro Asp Tyr Gly 202760DNAHomo sapiens
27tcaggtcagt gtccagaggg gtaaacctgt gtgaaaattg gcagaaaccc tgattatggc
60287PRTHomo sapiens 28Ser Gly Gln Cys Pro Glu Gly1 52960DNAHomo
sapiens 29tcagttctgc gatcattcag actgctccga gtcttcaagt tggcaaaatc
ctggccaaca 603020PRTHomo sapiens 30Ser Val Leu Arg Ser Phe Arg Leu
Leu Arg Val Phe Lys Leu Ala Lys1 5 10 15Ser Trp Pro Thr
203160DNAHomo sapiens 31tcagttctgc gatcattcag actgctctga gtcttcaagt
tggcaaaatc ctggccaaca 60329PRTHomo sapiens 32Ser Val Leu Arg Ser
Phe Arg Leu Leu1 53392DNAHomo sapiens 33atatgtgaca gagtttgtgg
acctgggcaa tgtctcagca ttgagaacat tcagagttct 60ccgagcattg aaaacaattt
cagtcattcc ag 923431PRTHomo sapiens 34Tyr Val Thr Glu Phe Val Asp
Leu Gly Asn Val Ser Ala Leu Arg Thr1 5 10 15Phe Arg Val Leu Arg Ala
Leu Lys Thr Ile Ser Val Ile Pro Gly 20 25 303592DNAHomo sapiens
35gtatttaaca gaatttgtaa acctaggcaa tgtttcagct cttcgaactt tcagagtatt
60gagagctttg aaaactattt ctgtaatccc ag 923692DNALepus americanus
36atatgtgacg gagtttgtgg acctgggcaa tgtctcagcg ttgagaacat tcagagttct
60ccgagctttg aaaacaattt cagtcattcc ag 923792DNALepus americanus
37gtatttaaca gaatttgtaa acctaggcaa tgtttcagct cttcgaactt tcagagtctt
60gagagctttg aaaactattt ctgtaatccc ag 923892DNAHomo sapiens
38atatgtgaca gagtttgtgg acctgggcaa tgtctcagcg ttgagaacat tcagagttct
60ccgagcattg aaaacaattt cagtcattcc ag 923992DNAHomo sapiens
39gtatgtaaca gaatttgtaa acctaggcaa tgtttcagct cttcgaactt tcagagtctt
60gagagctttg aaaactattt ctgtaattcc ag 924092DNARattus norvegicus
40atatgtgaca gagtttgtgg acctgggcaa tgtctcagcg ctgagaacgt tcagagttct
60ccgagcattg aaaacaatat cagtcattcc ag 924192DNARattus norvegicus
41gtatgtaaca gaatttgtaa acctaggcaa tgtttcagct cttcgaactt tcagagtctt
60gagagctttg aaaactattt ctgtaattcc ag 924292DNAHomo sapiens
42atatgtgaca gagtttgtgg acctgggcaa tgtctcagcg ttgagaacat tcagagttct
60ccgagcactg aaaacaattt cagtcattcc ag 924392DNAHomo sapiens
43gtatgtaaca gaatttgtaa gcctaggcaa tgtttcagcc cttcgaactt tcagagtctt
60gagagctctg aaaactattt ctgtaattcc ag 924492DNARattus norvegicus
44atatgtgaca gagtttgtgg acctgggcaa tgtctcagcg ctgagaacgt tcagagttct
60ccgagcattg aaaacaatat cagtcattcc ag 924592DNARattus norvegicus
45gtatgtaaca gaatttgtaa gcctaggcaa tgtttcagcc cttcgaactt tcagagtctt
60gcgagctctg aaaactattt ctgtaattcc ag 924624DNAHomo sapiens
46aaaagtgatt gattcagttt tttg 244720DNAHomo sapiens 47aaaagtgatt
cagttttttg 204821DNAHomo sapiens 48cagaggggta cacctgtgtg a
214921DNAHomo sapiens 49cagaggggta aacctgtgtg a 215021DNAHomo
sapiens 50cttttagctc cgagtcttca a 215121DNAHomo sapiens
51cttttagctc tgagtcttca a 215222DNAHomo sapiens 52ctgctggctg
ggatggattt gc 225322DNAHomo sapiens 53ctgctggctg agatggattt gc
225421DNAHomo sapiens 54ctggcaaaca actgcccttc a 215521DNAHomo
sapiens 55ctggcaaaca gctgcccttc a 215621DNAHomo sapiens
56tgaataaccc gccggactgg a 215721DNAHomo sapiens 57tgaataaccc
accggactgg a 215821DNAHomo sapiens 58cgctgcgtgc cgctggcaaa a
215921DNAHomo sapiens 59cgctgcgtgc tgctggcaaa a 216021DNAHomo
sapiens 60aagaattaga gtttcaacag a 216121DNAHomo sapiens
61aagaattaga atttcaacag a 216221DNAHomo sapiens 62tgttagaccg
acttaaaaaa g 216321DNAHomo sapiens 63tgttagaccg tcttaaaaaa g
216419DNAHomo sapiens 64gttgtgtacg gaggttctc 196519DNAHomo sapiens
65gttgtgtatg gaggttctc 196621DNAHomo sapiens 66cgtattttgt
gtcccctacc c 216721DNAHomo sapiens 67cgtattttgt ttcccctacc c
216822DNAHomo sapiens 68tttgcacctt tgaagactct gg 226922DNAHomo
sapiens 69tttgcacctt gaaagactct gg 227021DNAHomo sapiens
70atttttttct aaggaaaagt t 217121DNAHomo sapiens 71atttttttct
taggaaaagt t 217221DNAHomo sapiens 72atattcttag ttatttcaag t
217321DNAHomo sapiens 73atattcttag ctatttcaag t 217421DNAHomo
sapiens 74ctttttgaaa tggcaaattt a 217521DNAHomo sapiens
75ctttttgaaa cggcaaattt a 217621DNAHomo sapiens 76tcagaaaaat
tgatttttac a 217721DNAHomo sapiens 77tcagaaaaat ggatttttac a
217821DNAHomo sapiens 78ggatgcatat tgcctgggac c 217921DNAHomo
sapiens 79ggatgcatat cgcctgggac c 218021DNAHomo sapiens
80tttgaatggc atatgtacct g 218121DNAHomo sapiens 81tttgaatggc
gtatgtacct g 218221DNAHomo sapiens 82ggcatatgta tctggtgtat g
218321DNAHomo sapiens 83ggcatatgta cctggtgtat g 218421DNAHomo
sapiens 84gcggtatatg cttggccttc t 218521DNAHomo sapiens
85gcggtatatg tttggccttc t 218621DNAHomo sapiens 86cccataatca
cctcactgca t 218721DNAHomo sapiens 87cccataatca tctcactgca t
218821DNAHomo sapiens 88tttgtgaagc ttggggattg a 218921DNAHomo
sapiens 89tttgtgaagc ctggggattg a 219022DNAHomo sapiens
90attttttttt tagggcacga cc 229123DNAHomo sapiens 91attttttttt
ttagggcacg acc 239221DNAHomo sapiens 92atgttctctg tttttttctc c
219321DNAHomo sapiens 93atgttctctg cttttttctc c 219421DNAHomo
sapiens 94tagtgagttt tagaattgac t 219521DNAHomo sapiens
95tagtgagttt cagaattgac t 219621DNAHomo sapiens 96tgttattttt
ataggtttct t 219721DNAHomo sapiens 97tgttattttt gtaggtttct t
219822DNAHomo sapiens 98cgaaggatat aagttattct tt 229920DNAHomo
sapiens 99cgaaggatat gttattcttt 2010021DNAHomo sapiens
100tttaaatagt ctattaatta t 2110121DNAHomo sapiens 101tttaaatagt
atattaatta t 2110220DNAHomo sapiens 102tttaaaaaaa tctttacatt
2010321DNAHomo sapiens 103tttaaaaaaa atctttacat t 2110421DNAHomo
sapiens 104ataattaact aggactaaga t 2110521DNAHomo sapiens
105ataattaact gggactaaga t 2110621DNAHomo sapiens 106ttcatgatta
attttattag a 2110721DNAHomo sapiens 107ttcatgatta gttttattag a
2110820DNAHomo sapiens 108ttttttgttt ctttaccttg 2010924DNAHomo
sapiens 109ttttttgttt gtttctttac cttg 2411021DNAHomo sapiens
110aatatttatt attcagattt t 2111121DNAHomo sapiens 111aatatttatt
tttcagattt t 2111251DNAHomo sapiens 112ctgccagagg tgataataga
taaggcaact tctgatgaca gcgtaaggac g 5111314PRTHomo sapiens 113Leu
Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp Ser1 5 10
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