U.S. patent application number 13/195490 was filed with the patent office on 2011-12-01 for extractable filler for inserting medicine into animal tissue.
This patent application is currently assigned to Crosstrees Medical, Inc.. Invention is credited to Kwan Ku Lin, Philip S. Yuan.
Application Number | 20110295231 13/195490 |
Document ID | / |
Family ID | 33448869 |
Filed Date | 2011-12-01 |
United States Patent
Application |
20110295231 |
Kind Code |
A1 |
Lin; Kwan Ku ; et
al. |
December 1, 2011 |
EXTRACTABLE FILLER FOR INSERTING MEDICINE INTO ANIMAL TISSUE
Abstract
An extractable device is used to insert a medicinal filling into
an animal tissue. The device comprises a filling member and a pasty
medicine. The filling member is made of a flexible and permeable
wall and is provided with a holding portion and an injection port
via which the pasty medicine is injected into the holding portion
after the filling member is inserted into the animal tissue. The
holding portion is provided with an opening which is releasably
lashed by one end of one or more threads so as to make the opening
leakproof. Upon completion of solidification of the pasty medicine
in the holding portion of the filling member, other end of the
thread is pulled to unlash the opening of the holding portion,
thereby enabling the filling member to be extracted from the animal
tissue so as to leave only the medicine in the animal tissue.
Inventors: |
Lin; Kwan Ku; (San Marino,
CA) ; Yuan; Philip S.; (Long Beach, CA) |
Assignee: |
Crosstrees Medical, Inc.
Boulder
CO
|
Family ID: |
33448869 |
Appl. No.: |
13/195490 |
Filed: |
August 1, 2011 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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11674085 |
Feb 12, 2007 |
8007500 |
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13195490 |
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10651988 |
Sep 2, 2003 |
7175627 |
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11674085 |
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Current U.S.
Class: |
604/506 ;
604/288.01; 604/288.04; 604/500 |
Current CPC
Class: |
A61M 37/00 20130101 |
Class at
Publication: |
604/506 ;
604/288.01; 604/500; 604/288.04 |
International
Class: |
A61M 5/00 20060101
A61M005/00 |
Foreign Application Data
Date |
Code |
Application Number |
May 21, 2003 |
TW |
92113774 |
Claims
1. An extractable device for inserting a solidifiable medicinal
filling into an animal tissue, comprising: a flexible, permeable
container having a proximal injection port for injection of the
filling into the container, and a releasably closable distal
opening for delivery of the filling into the animal tissue outside
of the container; and at least one releasable thread that
releasably closes the distal opening to contain the filling within
the container prior to solidification, and that reopens the distal
opening to enable the delivery of the filling into the animal
tissue outside of the container after solidification.
2. The device of claim 1, in which the thread is releasable upon
application of an external pulling force.
3. The device of claim 1, in which the thread is releasable upon
application of an external pushing force.
4. The device of claim 1, in which the container is sufficiently
flexible for removal from the animal tissue after solidification of
the filling within the container.
5. The device of claim 1, in which the container is shaped like a
bag.
6. The device of claim 1, in which the container is shaped like a
ball.
7. The device of claim 1, in which the container comprises a
tubular wall.
8. The device of claim 1, in which the container comprises a
holding portion integrally formed by a wall of the flexible and
permeable container.
9. The device of claim 1, in which the container comprises a
single-layered wall.
10. The device of claim 1, in which the container comprises a
multi-layered wall.
11. The device of claim 1, in which the container comprises inner
and outer layers.
12. The device of claim 1, further comprising means for injecting
the solidifiable medicinal filling into the device through the
injection port.
13. The device of claim 1, in which the permeable container is
formed of a plurality of threads.
14. The device of claim 1, in which the permeable container is
formed of a plurality of threads by weaving.
15. In combination, the device of claim 1 and an injection tool for
injecting the solidifiable medicinal filling into the device
through the injection port.
16. The combination of claim 13, in which the injection tool
comprises a guide tube connected to the injection port.
17. A method for implanting a solidified medicine into an animal
tissue, comprising: inserting into the animal tissue a flexible,
permeable container having a distal opening that is releasably
closable; at least partially filling the container with a
solidifiable medicinal filling; solidifying the medicinal filling
within the container; reopening the distal opening of the
container; and depositing the filling into the animal tissue
through the distal opening by extracting the container from the
animal tissue.
18. The method of claim 17, further comprising injecting the
filling into the container through an injection port on a proximal
end of the container.
19. An extractable device for placing a solidifiable medicinal
filling into an animal tissue, comprising: a flexible, permeable
container, comprising a proximal inlet for receipt of the filling
and a releasably closable distal outlet for subsequent delivery of
solidified filling into the animal tissue; at least one releasable
thread to reduce leakage of the filling from the container.
20. A method for placing a solidified medicine into an animal
tissue, comprising: inserting into the animal tissue a flexible,
permeable container having a proximal inlet and a distal,
releasably leakproof outlet; providing the container with a
solidifiable medicinal filling through the proximal inlet;
solidifying the filling within the container; reopening the distal
outlet; delivering the solidified filling into the animal tissue
through the distal outlet opening; and removing the container from
the animal tissue.
Description
FIELD OF THE INVENTION
[0001] The present invention relates generally to an instrument
which is used in the restorative operation of animal tissue
disorder. More specifically this surgical instrument can be used to
insert a medical material into an animal tissue such that the
instrument can be separated from the medical material and drawn out
of the animal tissue so as to avert the possibility of tissue
rejection.
BACKGROUND OF THE INVENTION
[0002] The surgical treatment of animal tissue disorder can be
generally attained by one of three methods, which include the
hypodermic injection of medicine, the balloon-insertion of
medicine, and the filler-insertion of medicine. For example, the
U.S. Pat. Nos. 5,972,105; 6,066,154; and 6,248,110B1 disclose
respectively a method for treating bone tissue disorders, such as
osteoporosis and vertebral compression fractures. The method
involves the use of a balloon (made by the Kyphon Crop., U.S.A.) by
which the tissue is expanded to facilitate the inserting of the
medicine. This balloon method is defective in design in that the
medicine is apt to spread aimlessly in the tissue without boundary.
Without containment, the medicine is not as effective and there is
the possibility of injury to the surrounding tissues.
[0003] In order to prevent the drawbacks of the balloon method
described above, the filler-insertion method is used to implant the
medicine in animal tissue in such a way that the medicine is
contained in the filler, and that both the medicine and the filler
are implanted in the animal tissue. This filler-insertion method is
often carried out in danger of the tissue rejection of the
filler.
SUMMARY OF THE INVENTION
[0004] An extractable device for inserting a medicinal filling into
an animal tissue, said device comprising:
[0005] a filling member comprising a flexible and permeable wall
and provided with a holding portion, an injection port at one end
of the holding portion, and an opening at another end of the
holding portion;
[0006] one or more thread, each having one end for fastening
releasably said opening of said holding portion in such a manner
that said opening is leakproof; and
[0007] a pasty medicine to be injected into said holding portion
via said injection port of said filling member in the wake of a
process for inserting said filling member into the animal tissue
whereby said pasty medicine solidifies in said holding portion of
said filling member;
[0008] said opening of said holding portion being unfastened at the
time when other end of said threads is pulled by an external force,
thereby enabling said filling member to be extracted from the
animal tissue so as to leave only said medicine in the animal
tissue.
[0009] Preferably, wherein said flexible and permeable wall is of a
one-layered or multi-layered construction.
[0010] Preferably, said holding portion of said filling member is
integrally formed by said flexible and permeable wall into a body
in the form of sac, bag, or ball.
[0011] Preferably, said pasty medicine is a mixture of a liquid and
a medicinal powdered substance or medicinal granular substance.
[0012] Preferably, the device of the present invention further
comprises an injection tool for injecting said pasty medicine into
said holding portion via said injection port.
[0013] Preferably, said injection tool comprises a guide tube and a
syringe, wherein one end of said guide tube is connected to said
injection port of said filling member and another end of said guide
tube is connected to said syringe in which said pasty medicine is
held, so that said pasty medicine is able to be injected into said
holding portion of said filling member by said syringe via said
injection port and said guide tube.
[0014] Preferably, said flexible and permeable wall is a
double-layer tubular wall having one end of an inner layer thereof
being provided with said injection port of said holding portion,
and having another end thereof being a folded double-layer end with
said opening of said holding portion, wherein said medicine is
released from said filling member by pulling a free end of an outer
layer of the double-layer tubular wall to retreat the folded
double-layer end, after said opening of said holding portion being
unfastened.
[0015] Preferably, said one or more thread is between said inner
layer and said outer layer of said double-layer tubular wall.
[0016] According to another aspect of the present invention an
extractable device for inserting a medicinal filling into an animal
tissue, said device comprises:
[0017] a filling member comprising a flexible and permeable wall
which is formed of a plurality of threads by weaving, said filling
member provided with a holding portion and an injection port at one
end of the holding portion, said threads having a pull end
extending out of said filling member; and
[0018] a pasty medicine to be injected into said holding portion
via said injection port of said filling member in the wake of a
process for inserting said filling member into the animal tissue
whereby said pasty medicine solidifies in said holding portion of
said filling member;
[0019] said flexible and permeable wall of said filling member
being disintegrated at the time when the pull end of said threads
is pulled by an external force, thereby enabling said filling
member to be extracted from the animal tissue so as to leave only
said medicine in the animal tissue.
[0020] The present invention also discloses a method for implanting
a solidified medicine into an animal tissue comprising:
[0021] inserting a filling member in a hole of an animal tissue,
said filling member comprising a flexible and permeable wall and
provided with a holding portion, an injection port at one end of
the holding portion, and an opening at another end of the holding
portion, wherein one or more thread is provided and each having one
end fastening releasably said opening of said holding portion in
such a manner that said opening is leakproof;
[0022] injecting a pasty medicine into said holding portion via
said injection port of said filling member, whereby said pasty
medicine solidifies in said holding portion of said filling member;
and
[0023] unfastening said opening of said holding portion by pulling
other end of said threads, thereby enabling said filling member to
be extracted from the animal tissue so as to leave only said
solidified medicine in the animal tissue.
[0024] Preferably, the method further comprises fastening
detachably an injection tool with said filling member, so that said
pasty medicine is injected into said holding portion via said
injection tool. More preferably, said injection tool comprises a
guide tube and a syringe, wherein one end of said guide tube is
connected to said injection port of said filling member and another
end of said guide tube is connected to said syringe in which said
pasty medicine is held, wherein said pasty medicine is injected
into said holding portion of said filling member by said syringe
via said injection port and said guide tube.
[0025] The flexible wall of the filling member of the present
invention is made of a biocompatible or biosynthetic material, such
as rubber, elastic plastic, titanium, goat intestine, and the like.
The flexible wall is provided with a plurality of pores and is
therefore permeable. The flexible wall can be formed into an object
in the form of sac, bag, ball, cylinder or rectangular column
integrally or by joining separate pieces.
[0026] The filling member of the present invention may contain a
ray imaging material, such as a metal wire, by which the precise
position of the filling member can be easily located by a ray
imaging system, such as an X-ray machine.
[0027] The flexible wall of the filling member of the present
invention may be of a one-layered or multi-layered construction,
depending on the particle size and the viscosity of the medicine.
If the particle size of the medicine is relatively large, the
flexible wall is preferably of a two-layered construction. If the
viscosity of the medicine is relatively high, the flexible wall is
also preferably of a two-layered construction. On the other hand,
the flexible wall is preferably of a three-layered or four-layered
construction under the circumstances that he particle size of the
medicine is relatively small and that he viscosity of the medicine
is relatively lower.
[0028] The features and the advantages of the present invention
will be more readily understood upon a thoughtful deliberation of
the following detailed description of the preferred embodiments of
the present invention with reference to the accompanying
drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
[0029] FIG. 1 shows a sectional schematic view of the present
invention.
[0030] FIGS. 2a-2c are schematic views illustrating the lashing of
the opening of the holding portion of the filling member of the
present invention.
[0031] FIG. 3a shows a longitudinal sectional view of a one-layered
wall of the filling member of the present invention.
[0032] FIG. 3b shows a longitudinal sectional view of a
multi-layered wall of the filling member of the present
invention.
[0033] FIGS. 4a and 4b are sectional schematic view of the present
invention at work.
[0034] FIGS. 5a-5c are schematic views illustrating the unlashing
of the opening of the holding portion of the filling member of the
present invention upon completion of the injection of the medicine
into the holding portion of the filling member.
[0035] FIG. 6a shows a schematic view of the connection tube of the
implantation-injection apparatus of the present invention.
[0036] FIGS. 6b and 6c are sectional schematic views illustrating
the process in which the filling member of the present invention is
extracted from the animal tissue.
[0037] FIGS. 7a and 7b are schematic views illustrating that the
opening of the holding portion of the filling member of the present
invention is releasably lashed by a thread.
[0038] FIGS. 8a-8d are schematic views illustrating a process in
which the opening of the holding portion of the filling member of
the present invention is releasably lashed by two threads in
conjunction with sewing.
[0039] FIG. 9a shows a schematic view of the flexible wall of the
present invention being made of two threads which are releasably
interlaced.
[0040] FIG. 9b is a schematic view to show that the two threads of
the flexible wall, as shown in FIG. 9a, are unfastened.
[0041] FIG. 10a is a schematic view illustrating a process in which
a double-layer wall of the holding portion of the filling member of
the present invention is formed.
[0042] FIG. 10b illustrating a process in which the double-layer
wall of the holding portion of the filling member of the present
invention is retreated from the solidified medicine.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0043] As shown in FIG. 1, an extractable filler 10 embodied in the
present invention comprises a filling member 20, a pasty medicine
30, a connection tube 40, and two threads 50 and 51. The filling
member 20 is formed of a flexible wall 21 and is provided with a
holding portion 22 and an injection port 23. The flexible wall 21
may be made of rubber with perforated holes or woven fabric with
meshed pores. The pasty medicine 30 is injected into the holding
portion 22 via the connection tube 40 and the injection port 23.
The dotted line 3-3 shows a direction in which a section of the
filling member 20 is taken.
[0044] As shown in FIG. 2a, the holding portion 22 of the filling
member 20 is provided with an opening 24 opposite to the injection
port 23 of the filling member 20. The opening 24 is lashed by two
threads 50 and 51. The first thread 50 has a first end 501 and a
second end 502, while the second thread 51 has a first end 511 and
a second end 512. The two threads 50 and 51 are in fact fastened
releasably to the flexible wall 21 near the opening 24. The way by
which they are fastened together is not shown in the drawing.
[0045] The opening 24 of the holding portion 22 of the filling
member 20 is securely tied up to prevent the medicine 30 from
leaking out of the holding portion 22 by means of the two threads
50 and 51 which are releasably entangled in such a manner that the
first end 511 of the second thread 51 is wound around the first
thread 50. Upon completion of the winding process, the flexible
wall 21 surrounding the opening 24 is located in a position between
the two threads 50 and 51, as indicated by a dotted line 4-4 in
FIG. 2b. Thereafter, both ends 501 and 502 of the first thread 50,
and the first end 511 of the second thread 51 are respectively
pulled rightward and leftwards at the same time, as illustrated in
FIG. 2c. As a result, the opening 24 of the filling member 20 is
leakproof.
[0046] The flexible wall 21 of the filling member 20 is of a
one-layered construction, as shown in FIG. 3a, or of a
multi-layered construction, as shown in FIG. 3b. The flexible wall
21 is provided with a plurality of pores 211 permeable to fluids.
If the flexible wall 21 is of a multi-layered construction, the
flexible walls 21 are laminated in such a way that the pores 211
are not corresponding in location to slow down the passage of the
fluids.
[0047] As shown in FIGS. 4a and 4b, the filling member 20 is first
inserted into a blind hole 71 of an animal tissue 70. The pasty
medicine 30 is then injected into the holding portion 22 of the
filling member 20 by a syringe 60 in conjunction with the
connection tube 40. The filling member 20 is thus inflated by the
medicine 30, as shown in FIG. 4b. The connection tube 40 has one
end 41 which is connected with the filling member 20, and another
end 42 which is connected to one end 611 of a barrel 61 of the
syringe 60. A plunger 62 is slidably inserted into another end 612
of the barrel 61 in which the pasty medicine 30 is contained.
[0048] The pasty medicine 30 is a mixture of a liquid and one or
more kinds of animal tissue drugs in the form of powder, granule,
or colloid. The pasty medicine 30 is capable of solidification.
[0049] Upon completion of the solidification of the pasty medicine
30 in the blind hole 71 of the animal tissue 70, the filling member
20 must be extracted from the blind hole 71 of the animal tissue
70, so as to leave only the medicine 30 in the blind hole 71 of the
animal tissue 70 to prevent the rejection of the filling member 20
by the animal tissue 70. The extraction of the filling member 20
from the blind hole 71 of the animal tissue 70 involves a first
step in which the second end 512 of the second thread 51 is pulled
upward as indicated by an arrow in FIG. 5a. As a result, the two
threads 50 and 51 become loosened, as shown in FIG. 5b. Thereafter,
the first end 501 of the first thread 50 and the second end 512 of
the second thread 51 are respectively pulled in a direction away
from the opening 24 of the filling member 20, as illustrated in
FIG. 5c. The opening 24 is thus unfastened completely.
[0050] As shown in FIG. 6a, the connection tube 40 is provided in
one end 41 with a pointed projection 411 inside the tube. As the
connection tube 40 is slightly twisted, the solidified medicine 30
is severed by the pointed projection 411 of the connection tube 40.
The filling member 20 can be drawn out of the blind hole 71 of the
animal tissue 70 by the connection tube 40, as illustrated in FIG.
6b and FIG. 6c. As a result, only the medicine 30 is left in the
blind hole 71 of the animal tissue.
[0051] The opening 24 of the filling member 20 may be fastened by
only one thread 50, as illustrated in FIGS. 7a and 7b. The thread
50 has a first end 501 and a second end 502. With the thread 50, a
knot is formed to lash the opening 24 of the filling member 20 in
such a manner that the flexible wall 21 of the opening 24 is
surrounded by a loop as indicated by a line 5-5 in FIG. 7a. With
the second end 502 of the thread 50 remaining in the stationary
state, the first end 501 is pulled to fasten the opening 24. The
opening 24 is unfastened by pulling the second end 502 of the
thread 20, thereby resulting in separation of the filling member 20
from the thread 50.
[0052] The thread 50 can be also used to form a different knot, as
shown in FIG. 7b. The flexible wall 21 of the opening 24 of the
filling member 20 is surrounded by a loop as indicated by a line
6-6 in FIG. 7b. As the first end 501 of the thread 50 is pulled in
a direction away from the filling member 20, the opening 24 of the
filling member 20 is lashed to become leakproof. The opening 24 of
the filling member 20 is unlashed to enable the filling member 20
to separate from the thread 50 by pulling the second end 502 of the
thread 50.
[0053] The opening 24 of the filling member 20 can be releasably
fastened by sewing in conjunction with two threads 50 and 51, as
illustrated in FIGS. 8a-8d. With the first thread 50, a plurality
of loops are formed. These loops are joined with the flexible wall
21 of the opening 24 by sewing. The second thread 51 is put through
the loops of the first thread 50. As the second thread 51 is pulled
out of the loops of the first thread 50, the first thread 50
becomes separated from the flexible wall 21 of the opening 24 of
the filling member 20, as illustrated in FIGS. 8b-8d. As a result,
the opening 24 is unfastened. Such a fastening as described above
is similar to that which is commonly used to fasten the opening of
a cement or flour bag.
[0054] As shown in FIGS. 9a and 9b, the flexible wall 21 of the
filling member 20 is in fact a flexible fabric which is made of two
threads 50 and 51 by weaving or knitting. The filling member 20 has
a saclike form. The filling member 20 can be broken up in its
entirety by pulling an exposed end of the thread 50, as shown in
FIG. 9b. It must be noted here that the flexible fabric is provided
with a plurality of meshes.
[0055] A further embodiment of the present invention is shown in
FIG. 10a, and FIG. 10b, which is similar to the embodiment shown in
FIGS. 1 to 2c, except that a filling member 80 is formed of a
double-layer wall 81 and the first thread 51 and second thread 52
are located between an inner layer 812 and an outer layer 811 of
the double-layer wall 81. As shown in FIG. 10a, a flexible and
permeable tubular wall is tied at an intermediate point thereof by
the threads 50 and 51 at the beginning. The lower portion 811 of
the tubular wall (will become an outer layer) is then rolled up, so
that it is inside out and covering up the threads 50 and 51 and the
upper portion 812 of the tubular wall (will become an inner layer).
The rolled-up end of said double-layer wall 81 is provided with an
opening 82 of the holding portion 22, which is lashed by the two
threads 50 and 51. The opening 82 is unfastened by pulling the
threads 50 and 51 the same way as shown in FIGS. 4a to 4c. As shown
in FIG. 10b, the rolled-up double-layer end is retreated from the
solidified medicine 30 by pulling a free end of the outer layer 811
of the double-layer wall 81, while one end of the inner layer 812
is connected to the connection tube 40 as an injection port of said
holding portion 22 of the said filling member 80, whereby said
solidified medicine 30 is released from said filling member 80. A
working tube 43 is used to accommodate the connection tube 40, the
threads 50 and 51 and the free end of the outer layer 811 of the
double-layer wall 81 of the filling member 80.
[0056] The embodiments of the present invention described above are
to be regarded in all respects as being illustrative and
nonrestrictive. Accordingly, the present invention may be embodied
in other specific forms without deviating from the spirit thereof.
The present invention is therefore to be limited only the scopes of
the following claims.
* * * * *