U.S. patent application number 13/180232 was filed with the patent office on 2011-11-24 for novel bag proteins and nucleic acid molecules encoding them. This patent application is currently assigned to Sanford-Burnham Medical Research Institute. Invention is credited to John C. Reed, Shinichi Takayama.
Application Number | 20110288002 13/180232 |
Document ID | / |
Family ID | 28677919 |
Filed Date | 2011-11-24 |
United States Patent Application | 20110288002 |
Kind Code | A1 |
Reed; John C. ; et al. | November 24, 2011 |
The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S. pombe (BAG-1A, BAG-1B) and the nucleic acid molecules that encode them.
Inventors: | Reed; John C.; (Rancho Santa Fe, CA) ; Takayama; Shinichi; (San Diego, CA) |
Assignee: | Sanford-Burnham Medical Research
Institute La Jolla CA |
Family ID: | 28677919 |
Appl. No.: | 13/180232 |
Filed: | July 11, 2011 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
12764058 | Apr 20, 2010 | 7982023 | ||
13180232 | ||||
11879274 | Jul 16, 2007 | 7723501 | ||
12764058 | ||||
10782627 | Feb 18, 2004 | 7615623 | ||
11879274 | ||||
09394142 | Sep 9, 1999 | 6696558 | ||
10782627 | ||||
60155212 | Sep 9, 1998 | |||
Current U.S. Class: | 514/1.1 ; 530/350; 536/23.5 |
Current CPC Class: | A61K 38/00 20130101; C07K 14/47 20130101; A61K 48/00 20130101 |
Class at Publication: | 514/1.1 ; 536/23.5; 530/350 |
International Class: | A61K 38/00 20060101 A61K038/00; C07K 14/00 20060101 C07K014/00; C07H 21/04 20060101 C07H021/04 |
Sequence CWU 1
1
2411291DNAHomo sapiensCDS(46)..(1080) 1acgccgcgct cagcttccat
cgctgggcgg tcaacaagtg cgggc ctg gct cag cgc 57 Leu Ala Gln Arg 1ggg
ggg gcg cgg aga ccg cga ggc gac cgg gag cgg ctg ggt tcc cgg 105Gly
Gly Ala Arg Arg Pro Arg Gly Asp Arg Glu Arg Leu Gly Ser Arg5 10 15
20ctg cgc gcc ctt cgg cca ggc cgg gag ccg cgc cag tcg gag ccc ccg
153Leu Arg Ala Leu Arg Pro Gly Arg Glu Pro Arg Gln Ser Glu Pro Pro
25 30 35gcc cag cgt ggt ccg cct ccc tct cgg cgt cca cct gcc cgg agt
act 201Ala Gln Arg Gly Pro Pro Pro Ser Arg Arg Pro Pro Ala Arg Ser
Thr 40 45 50gcc agc ggg cat gac cga ccc acc agg ggc gcc gcc gcc ggc
gct cgc 249Ala Ser Gly His Asp Arg Pro Thr Arg Gly Ala Ala Ala Gly
Ala Arg 55 60 65agg ccg cgg atg aag aag aaa acc cgg cgc cgc tcg acc
cgg agc gag 297Arg Pro Arg Met Lys Lys Lys Thr Arg Arg Arg Ser Thr
Arg Ser Glu 70 75 80gag ttg acc cgg agc gag gag ttg acc ctg agt gag
gaa gcg acc tgg 345Glu Leu Thr Arg Ser Glu Glu Leu Thr Leu Ser Glu
Glu Ala Thr Trp85 90 95 100agt gaa gag gcg acc cag agt gag gag gcg
acc cag ggc gaa gag atg 393Ser Glu Glu Ala Thr Gln Ser Glu Glu Ala
Thr Gln Gly Glu Glu Met 105 110 115aat cgg agc cag gag gtg acc cgg
gac gag gag tcg acc cgg agc gag 441Asn Arg Ser Gln Glu Val Thr Arg
Asp Glu Glu Ser Thr Arg Ser Glu 120 125 130gag gtg acc agg gag gaa
atg gcg gca gct ggg ctc acc gtg act gtc 489Glu Val Thr Arg Glu Glu
Met Ala Ala Ala Gly Leu Thr Val Thr Val 135 140 145acc cac agc aat
gag aag cac gac ctt cat gtt acc tcc cag cag ggc 537Thr His Ser Asn
Glu Lys His Asp Leu His Val Thr Ser Gln Gln Gly 150 155 160agc agt
gaa cca gtt gtc caa gac ctg gcc cag gtt gtt gaa gag gtc 585Ser Ser
Glu Pro Val Val Gln Asp Leu Ala Gln Val Val Glu Glu Val165 170 175
180ata ggg gtt cca cag tct ttt cag aaa ctc ata ttt aag gga aaa tct
633Ile Gly Val Pro Gln Ser Phe Gln Lys Leu Ile Phe Lys Gly Lys Ser
185 190 195ctg aag gaa atg gaa aca ccg ttg tca gca ctt gga ata caa
gat ggt 681Leu Lys Glu Met Glu Thr Pro Leu Ser Ala Leu Gly Ile Gln
Asp Gly 200 205 210tgc cgg gtc atg tta att ggg aaa aag aac agt cca
cag gaa gag gtt 729Cys Arg Val Met Leu Ile Gly Lys Lys Asn Ser Pro
Gln Glu Glu Val 215 220 225gaa cta aag aag ttg aaa cat ttg gag aag
tct gtg gag aag ata gct 777Glu Leu Lys Lys Leu Lys His Leu Glu Lys
Ser Val Glu Lys Ile Ala 230 235 240gac cag ctg gaa gag ttg aat aaa
gag ctt act gga atc cag cag ggt 825Asp Gln Leu Glu Glu Leu Asn Lys
Glu Leu Thr Gly Ile Gln Gln Gly245 250 255 260ttt ctg ccc aag gat
ttg caa gct gaa gct ctc tgc aaa ctt gat agg 873Phe Leu Pro Lys Asp
Leu Gln Ala Glu Ala Leu Cys Lys Leu Asp Arg 265 270 275aga gta aaa
gcc aca ata gag cag ttt atg aag atc ttg gag gag att 921Arg Val Lys
Ala Thr Ile Glu Gln Phe Met Lys Ile Leu Glu Glu Ile 280 285 290gac
aca ctg atc ctg cca gaa aat ttc aaa gac agt aga ttg aaa agg 969Asp
Thr Leu Ile Leu Pro Glu Asn Phe Lys Asp Ser Arg Leu Lys Arg 295 300
305aaa ggc ttg gta aaa aag gtt cag gca ttc cta gcc gag tgt gac aca
1017Lys Gly Leu Val Lys Lys Val Gln Ala Phe Leu Ala Glu Cys Asp Thr
310 315 320gtg gag cag aac atc tgc cag gag act gag cgg ctg cag tct
aca aac 1065Val Glu Gln Asn Ile Cys Gln Glu Thr Glu Arg Leu Gln Ser
Thr Asn325 330 335 340ttt gcc ctg gcc gag tgaggtgtag cagaaaaagg
ctgtgctgcc ctgaagaatg 1120Phe Ala Leu Ala Glu 345gcgccaccag
ctctgccgtc tctggatcgg aatttacctg atttcttcag ggctgctggg
1180ggcaactggc catttgccaa ttttcctact ctcacactgg ttctcaatga
aaaatagtgt 1240ctttgtgatt tgagtaaagc tcctattctg tttttcacaa
aaaaaaaaaa a 12912345PRTHomo sapiens 2Leu Ala Gln Arg Gly Gly Ala
Arg Arg Pro Arg Gly Asp Arg Glu Arg1 5 10 15Leu Gly Ser Arg Leu Arg
Ala Leu Arg Pro Gly Arg Glu Pro Arg Gln 20 25 30Ser Glu Pro Pro Ala
Gln Arg Gly Pro Pro Pro Ser Arg Arg Pro Pro 35 40 45Ala Arg Ser Thr
Ala Ser Gly His Asp Arg Pro Thr Arg Gly Ala Ala 50 55 60Ala Gly Ala
Arg Arg Pro Arg Met Lys Lys Lys Thr Arg Arg Arg Ser65 70 75 80Thr
Arg Ser Glu Glu Leu Thr Arg Ser Glu Glu Leu Thr Leu Ser Glu 85 90
95Glu Ala Thr Trp Ser Glu Glu Ala Thr Gln Ser Glu Glu Ala Thr Gln
100 105 110Gly Glu Glu Met Asn Arg Ser Gln Glu Val Thr Arg Asp Glu
Glu Ser 115 120 125Thr Arg Ser Glu Glu Val Thr Arg Glu Glu Met Ala
Ala Ala Gly Leu 130 135 140Thr Val Thr Val Thr His Ser Asn Glu Lys
His Asp Leu His Val Thr145 150 155 160Ser Gln Gln Gly Ser Ser Glu
Pro Val Val Gln Asp Leu Ala Gln Val 165 170 175Val Glu Glu Val Ile
Gly Val Pro Gln Ser Phe Gln Lys Leu Ile Phe 180 185 190Lys Gly Lys
Ser Leu Lys Glu Met Glu Thr Pro Leu Ser Ala Leu Gly 195 200 205Ile
Gln Asp Gly Cys Arg Val Met Leu Ile Gly Lys Lys Asn Ser Pro 210 215
220Gln Glu Glu Val Glu Leu Lys Lys Leu Lys His Leu Glu Lys Ser
Val225 230 235 240Glu Lys Ile Ala Asp Gln Leu Glu Glu Leu Asn Lys
Glu Leu Thr Gly 245 250 255Ile Gln Gln Gly Phe Leu Pro Lys Asp Leu
Gln Ala Glu Ala Leu Cys 260 265 270Lys Leu Asp Arg Arg Val Lys Ala
Thr Ile Glu Gln Phe Met Lys Ile 275 280 285Leu Glu Glu Ile Asp Thr
Leu Ile Leu Pro Glu Asn Phe Lys Asp Ser 290 295 300Arg Leu Lys Arg
Lys Gly Leu Val Lys Lys Val Gln Ala Phe Leu Ala305 310 315 320Glu
Cys Asp Thr Val Glu Gln Asn Ile Cys Gln Glu Thr Glu Arg Leu 325 330
335Gln Ser Thr Asn Phe Ala Leu Ala Glu 340 34531179DNAHomo
sapiensCDS(160)..(792) 3gcagccgcgg tgtcgcgaag tcctcccggg ttgcccccgc
ggcgtcagag ggagggcggg 60cgccgcgttg gtgacggcga ccctgcagcc caaggagcgc
tccactcgct gccgccggag 120ggccggtgac ctcttggcta ccccgcgtcg gaggcttag
atg gct cag gcg aag 174 Met Ala Gln Ala Lys 1 5atc aac gct aaa gcc
aac gag ggg cgc ttc tgc cgc tcc tcc tcc atg 222Ile Asn Ala Lys Ala
Asn Glu Gly Arg Phe Cys Arg Ser Ser Ser Met 10 15 20gct gac cgc tcc
agc cgc ctg ctg gag agc ctg gac cag ctg gag ctc 270Ala Asp Arg Ser
Ser Arg Leu Leu Glu Ser Leu Asp Gln Leu Glu Leu 25 30 35agg gtt gaa
gct ttg aga gaa gca gca act gct gtt gag caa gag aaa 318Arg Val Glu
Ala Leu Arg Glu Ala Ala Thr Ala Val Glu Gln Glu Lys 40 45 50gaa atc
ctt ctg gaa atg atc cac agt atc caa aat agc cag gac atg 366Glu Ile
Leu Leu Glu Met Ile His Ser Ile Gln Asn Ser Gln Asp Met 55 60 65agg
cag atc agt gac gga gaa aga gaa gaa tta aat ctg act gca aac 414Arg
Gln Ile Ser Asp Gly Glu Arg Glu Glu Leu Asn Leu Thr Ala Asn70 75 80
85cgt ttg atg gga aga act ctc acc gtt gaa gtg tca gta gaa aca att
462Arg Leu Met Gly Arg Thr Leu Thr Val Glu Val Ser Val Glu Thr Ile
90 95 100aga aac ccc cag cag caa gaa tcc cta aag cat gcc aca agg
att att 510Arg Asn Pro Gln Gln Gln Glu Ser Leu Lys His Ala Thr Arg
Ile Ile 105 110 115gat gag gtg gtc aat aag ttt ctg gat gat ttg gga
aat gcc aag agt 558Asp Glu Val Val Asn Lys Phe Leu Asp Asp Leu Gly
Asn Ala Lys Ser 120 125 130cat tta atg tcg ctc tac agt gca tgt tca
tct gag gtg cca cat ggg 606His Leu Met Ser Leu Tyr Ser Ala Cys Ser
Ser Glu Val Pro His Gly 135 140 145cca gtt gat cag aag ttt caa tcc
ata gta att ggc tgt gct ctt gaa 654Pro Val Asp Gln Lys Phe Gln Ser
Ile Val Ile Gly Cys Ala Leu Glu150 155 160 165gat cag aag aaa att
aag aga aga tta gag act ctg ctt aga aat att 702Asp Gln Lys Lys Ile
Lys Arg Arg Leu Glu Thr Leu Leu Arg Asn Ile 170 175 180gaa aac tct
gac aag gcc atc aag cta tta gag cat tct aaa gga gct 750Glu Asn Ser
Asp Lys Ala Ile Lys Leu Leu Glu His Ser Lys Gly Ala 185 190 195ggt
tcc aaa act ctg caa caa aat gct gaa agc aga ttc aat 792Gly Ser Lys
Thr Leu Gln Gln Asn Ala Glu Ser Arg Phe Asn 200 205 210tagtcttcaa
acctaagagc atttacacaa tacacaaggt gtaaaaatga taaaatacta
852ttttaattga taactagttc tttgttaggt ataaccactt agttgacact
gatagttgtt 912tcagatgagg aaaatattcc atcaagtatc ttcagttttg
tgaataacaa aactagcaat 972attttaatta tctatctaga gattttttag
attgaattct tgtcttgtac taggatctag 1032catatttcac tattctgtgg
atgaatacat agtttgtggg gaaaacaaac gttcagctag 1092gggcaaaaag
catgactgct ttttcctgtc tggcatggaa tcacgcagtc accttgggca
1152tttagtttac tagaaattct ttactgg 11794211PRTHomo sapiens 4Met Ala
Gln Ala Lys Ile Asn Ala Lys Ala Asn Glu Gly Arg Phe Cys1 5 10 15Arg
Ser Ser Ser Met Ala Asp Arg Ser Ser Arg Leu Leu Glu Ser Leu 20 25
30Asp Gln Leu Glu Leu Arg Val Glu Ala Leu Arg Glu Ala Ala Thr Ala
35 40 45Val Glu Gln Glu Lys Glu Ile Leu Leu Glu Met Ile His Ser Ile
Gln 50 55 60Asn Ser Gln Asp Met Arg Gln Ile Ser Asp Gly Glu Arg Glu
Glu Leu65 70 75 80Asn Leu Thr Ala Asn Arg Leu Met Gly Arg Thr Leu
Thr Val Glu Val 85 90 95Ser Val Glu Thr Ile Arg Asn Pro Gln Gln Gln
Glu Ser Leu Lys His 100 105 110Ala Thr Arg Ile Ile Asp Glu Val Val
Asn Lys Phe Leu Asp Asp Leu 115 120 125Gly Asn Ala Lys Ser His Leu
Met Ser Leu Tyr Ser Ala Cys Ser Ser 130 135 140Glu Val Pro His Gly
Pro Val Asp Gln Lys Phe Gln Ser Ile Val Ile145 150 155 160Gly Cys
Ala Leu Glu Asp Gln Lys Lys Ile Lys Arg Arg Leu Glu Thr 165 170
175Leu Leu Arg Asn Ile Glu Asn Ser Asp Lys Ala Ile Lys Leu Leu Glu
180 185 190His Ser Lys Gly Ala Gly Ser Lys Thr Leu Gln Gln Asn Ala
Glu Ser 195 200 205Arg Phe Asn 21052528DNAHomo
sapiensCDS(1)..(2031)misc_feature(1)..(2528)n= a, c, t or g 5gcg
gag ctc cgc atc caa ccc cgg gcc gcg gcc aac ttc tct gga ctg 48Ala
Glu Leu Arg Ile Gln Pro Arg Ala Ala Ala Asn Phe Ser Gly Leu1 5 10
15gac cag aag ttt cta gcc ggc cag ttg cta cct ccc ttt atc tcc tcc
96Asp Gln Lys Phe Leu Ala Gly Gln Leu Leu Pro Pro Phe Ile Ser Ser
20 25 30ttc ccc tct ggc agc gag gag gct att tcc aga cac ttc cac ccc
tct 144Phe Pro Ser Gly Ser Glu Glu Ala Ile Ser Arg His Phe His Pro
Ser 35 40 45ctg gcc acg tca ccc ccg cct tta att cat aaa ggt gcc cgg
cgc cgg 192Leu Ala Thr Ser Pro Pro Pro Leu Ile His Lys Gly Ala Arg
Arg Arg 50 55 60ctt ccc gga cac gtc ggc ggc gga gag ggg ccc acg gcg
gcg gcc cgg 240Leu Pro Gly His Val Gly Gly Gly Glu Gly Pro Thr Ala
Ala Ala Arg65 70 75 80cca gag act cgg cgc ccg gag cca gcg ccc cgc
acc cgc gcc cca gcg 288Pro Glu Thr Arg Arg Pro Glu Pro Ala Pro Arg
Thr Arg Ala Pro Ala 85 90 95ggc aga ccc caa ccc agc atg agc gcc gcc
acc cac tcg ccc atg atg 336Gly Arg Pro Gln Pro Ser Met Ser Ala Ala
Thr His Ser Pro Met Met 100 105 110cag gtg gcg tcc ggc aac ggt gac
cgc gac cct ttg ccc ccc gga tgg 384Gln Val Ala Ser Gly Asn Gly Asp
Arg Asp Pro Leu Pro Pro Gly Trp 115 120 125gag atc aag atc gac ccg
cag acc ggc tgg ccc ttc ttc gtg gac cac 432Glu Ile Lys Ile Asp Pro
Gln Thr Gly Trp Pro Phe Phe Val Asp His 130 135 140aac agc cgc acc
act acg tgg aac gac ccg cgc gtg ccc tct gag ggc 480Asn Ser Arg Thr
Thr Thr Trp Asn Asp Pro Arg Val Pro Ser Glu Gly145 150 155 160ccc
aag gag act cca tcc tct gcc aat ggc cct tcc cgg gag ggc tct 528Pro
Lys Glu Thr Pro Ser Ser Ala Asn Gly Pro Ser Arg Glu Gly Ser 165 170
175agg ctg ccg cct gct agg gaa ggc cac cct gtg tac ccc cag ctc cga
576Arg Leu Pro Pro Ala Arg Glu Gly His Pro Val Tyr Pro Gln Leu Arg
180 185 190cca ggc tac att ccc att cct gtg ctc cat gaa ggc gct gag
aac cgg 624Pro Gly Tyr Ile Pro Ile Pro Val Leu His Glu Gly Ala Glu
Asn Arg 195 200 205cag gtg cac cct ttc cat gtc tat ccc cag cct ggg
atg cag cga ttc 672Gln Val His Pro Phe His Val Tyr Pro Gln Pro Gly
Met Gln Arg Phe 210 215 220cga act gag gcg gca gca gcg gct cct cag
agg tcc cag tca cct ctg 720Arg Thr Glu Ala Ala Ala Ala Ala Pro Gln
Arg Ser Gln Ser Pro Leu225 230 235 240cgg ggc atg cca gaa acc act
cag cca gat aaa cag tgt gga cag gtg 768Arg Gly Met Pro Glu Thr Thr
Gln Pro Asp Lys Gln Cys Gly Gln Val 245 250 255gca gcg gcg gcg gca
gcc cag ccc cca gcc tcc cac gga cct gag cgg 816Ala Ala Ala Ala Ala
Ala Gln Pro Pro Ala Ser His Gly Pro Glu Arg 260 265 270tcc cag tct
cca gct gcc tct gac tgc tca tcc tca tcc tcc tcg gcc 864Ser Gln Ser
Pro Ala Ala Ser Asp Cys Ser Ser Ser Ser Ser Ser Ala 275 280 285agc
ctg cct tcc tcc ggc agg agc agc ctg ggc agt cac cag ctc ccg 912Ser
Leu Pro Ser Ser Gly Arg Ser Ser Leu Gly Ser His Gln Leu Pro 290 295
300cgg ggg tac atc tcc att ccg gtg ata cac gag cag aac gtt acc cgg
960Arg Gly Tyr Ile Ser Ile Pro Val Ile His Glu Gln Asn Val Thr
Arg305 310 315 320cca gca gcc cag ccc tcc ttc cac aaa gcc cag aag
acg cac tac cca 1008Pro Ala Ala Gln Pro Ser Phe His Lys Ala Gln Lys
Thr His Tyr Pro 325 330 335gcg cag agg ggt gag tac cag acc cac cag
cct gtg tac cac aag atc 1056Ala Gln Arg Gly Glu Tyr Gln Thr His Gln
Pro Val Tyr His Lys Ile 340 345 350cag ggg gat gac tgg gag ccc cgg
ccc ctg cgg gcg gca tcc ccg ttc 1104Gln Gly Asp Asp Trp Glu Pro Arg
Pro Leu Arg Ala Ala Ser Pro Phe 355 360 365agg tca tct gtc cag ggt
gca tcg agc cgg gag ggc tca cca gcc agg 1152Arg Ser Ser Val Gln Gly
Ala Ser Ser Arg Glu Gly Ser Pro Ala Arg 370 375 380agc agc acg cca
ctc cac tcc ccc tcg ccc atc cgt gtg cac acc gtg 1200Ser Ser Thr Pro
Leu His Ser Pro Ser Pro Ile Arg Val His Thr Val385 390 395 400gtc
gac agg cct cag cag ccc atg acc cat cga gaa act gca cct gtt 1248Val
Asp Arg Pro Gln Gln Pro Met Thr His Arg Glu Thr Ala Pro Val 405 410
415tcc cag cct gaa aac aaa cca gaa agt aag cca ggc cca gtt gga cca
1296Ser Gln Pro Glu Asn Lys Pro Glu Ser Lys Pro Gly Pro Val Gly Pro
420 425 430gaa ctc cct cct gga cac atc cca att caa gtg atc cgc aaa
gag gtg 1344Glu Leu Pro Pro Gly His Ile Pro Ile Gln Val Ile Arg Lys
Glu Val 435 440 445gat tct aaa cct gtt tcc cag aag ccc cca cct ccc
tct gag aag gta 1392Asp Ser Lys Pro Val Ser Gln Lys Pro Pro Pro Pro
Ser Glu Lys Val 450 455 460gag gtg aaa gtt ccc cct gct cca gtt cct
tgt cct cct ccc agc cct 1440Glu Val Lys Val Pro Pro Ala Pro Val Pro
Cys Pro Pro Pro Ser Pro465 470 475 480ggc cct tct gct gtc ccc tct
tcc ccc aag agt gtg gct aca gaa gag 1488Gly Pro Ser Ala Val Pro Ser
Ser Pro Lys Ser Val Ala Thr Glu Glu 485 490 495agg gca gcc ccc agc
act gcc cct gca gaa gct aca cct cca aaa cca 1536Arg Ala Ala Pro Ser
Thr Ala Pro Ala Glu Ala Thr Pro Pro Lys Pro 500 505 510gga gaa gcc
gag gct ccc cca aaa cat cca gga gtg ctg aaa gtg gaa
1584Gly Glu Ala Glu Ala Pro Pro Lys His Pro Gly Val Leu Lys Val Glu
515 520 525gcc atc ctg gag aag gtg cag ggg ctg gag cag gct gta gac
aac ttt 1632Ala Ile Leu Glu Lys Val Gln Gly Leu Glu Gln Ala Val Asp
Asn Phe 530 535 540gaa ggc aag aag act gac aaa aag tac ctg atg atc
gaa gag tat ttg 1680Glu Gly Lys Lys Thr Asp Lys Lys Tyr Leu Met Ile
Glu Glu Tyr Leu545 550 555 560acc aaa gag ctg ctg gcc ctg gat tca
gtg gac ccc gag gga cga gcc 1728Thr Lys Glu Leu Leu Ala Leu Asp Ser
Val Asp Pro Glu Gly Arg Ala 565 570 575gat gtg cgt cag gcc agg aga
gac ggt gtc agg aag gtt cag acc atc 1776Asp Val Arg Gln Ala Arg Arg
Asp Gly Val Arg Lys Val Gln Thr Ile 580 585 590ttg gaa aaa ctt gaa
cag aaa gcc att gat gtc cca ggt caa gtc cag 1824Leu Glu Lys Leu Glu
Gln Lys Ala Ile Asp Val Pro Gly Gln Val Gln 595 600 605gtc tat gaa
ctc cag ccc agc aac ctt gaa gca gat cag cca ctg cag 1872Val Tyr Glu
Leu Gln Pro Ser Asn Leu Glu Ala Asp Gln Pro Leu Gln 610 615 620gca
atc atg gag atg ggt gcc gtg gca gca gac aag ggc aag aaa aat 1920Ala
Ile Met Glu Met Gly Ala Val Ala Ala Asp Lys Gly Lys Lys Asn625 630
635 640gct gga aat gca gaa gat ccc cac aca gaa acc cag cag cca gaa
gcc 1968Ala Gly Asn Ala Glu Asp Pro His Thr Glu Thr Gln Gln Pro Glu
Ala 645 650 655aca gca gca gcg act tca aac ccc agc agc atg aca gac
acc cct ggt 2016Thr Ala Ala Ala Thr Ser Asn Pro Ser Ser Met Thr Asp
Thr Pro Gly 660 665 670aac cca gca gca ccg tagcctctgc cctgtaaaag
tcagactcgg aaccgatgtg 2071Asn Pro Ala Ala Pro 675tgctttaggg
attttagttg catgcatttc agagacttta ggtcagttgg ttttgattag
2131ctgcttggta tgcagtactt gggtgaggca aacactataa agggctaaaa
gggaaaatga 2191tgcttttctt caatattctt actcttgtac aattaangaa
gttgcttgtt gtttgagaag 2251tttaaccccg ttgcttgttc tgcagccctg
tcnacttggg cacccccacc acctgttagc 2311tgtggttgtg cactgtcttt
tgtagctctg gactggaggg gtagatgggg agtcaattac 2371ccatcacata
aatatgaaac atttatcaga aatgttgcca ttttaatgag atgattttct
2431tcatctcata attaaaatac ctgactttag agagagtaaa atgtgccagg
agccatagga 2491atatctgtat gttggatgac tttaatgcta catttth
25286677PRTHomo sapiens 6Ala Glu Leu Arg Ile Gln Pro Arg Ala Ala
Ala Asn Phe Ser Gly Leu1 5 10 15Asp Gln Lys Phe Leu Ala Gly Gln Leu
Leu Pro Pro Phe Ile Ser Ser 20 25 30Phe Pro Ser Gly Ser Glu Glu Ala
Ile Ser Arg His Phe His Pro Ser 35 40 45Leu Ala Thr Ser Pro Pro Pro
Leu Ile His Lys Gly Ala Arg Arg Arg 50 55 60Leu Pro Gly His Val Gly
Gly Gly Glu Gly Pro Thr Ala Ala Ala Arg65 70 75 80Pro Glu Thr Arg
Arg Pro Glu Pro Ala Pro Arg Thr Arg Ala Pro Ala 85 90 95Gly Arg Pro
Gln Pro Ser Met Ser Ala Ala Thr His Ser Pro Met Met 100 105 110Gln
Val Ala Ser Gly Asn Gly Asp Arg Asp Pro Leu Pro Pro Gly Trp 115 120
125Glu Ile Lys Ile Asp Pro Gln Thr Gly Trp Pro Phe Phe Val Asp His
130 135 140Asn Ser Arg Thr Thr Thr Trp Asn Asp Pro Arg Val Pro Ser
Glu Gly145 150 155 160Pro Lys Glu Thr Pro Ser Ser Ala Asn Gly Pro
Ser Arg Glu Gly Ser 165 170 175Arg Leu Pro Pro Ala Arg Glu Gly His
Pro Val Tyr Pro Gln Leu Arg 180 185 190Pro Gly Tyr Ile Pro Ile Pro
Val Leu His Glu Gly Ala Glu Asn Arg 195 200 205Gln Val His Pro Phe
His Val Tyr Pro Gln Pro Gly Met Gln Arg Phe 210 215 220Arg Thr Glu
Ala Ala Ala Ala Ala Pro Gln Arg Ser Gln Ser Pro Leu225 230 235
240Arg Gly Met Pro Glu Thr Thr Gln Pro Asp Lys Gln Cys Gly Gln Val
245 250 255Ala Ala Ala Ala Ala Ala Gln Pro Pro Ala Ser His Gly Pro
Glu Arg 260 265 270Ser Gln Ser Pro Ala Ala Ser Asp Cys Ser Ser Ser
Ser Ser Ser Ala 275 280 285Ser Leu Pro Ser Ser Gly Arg Ser Ser Leu
Gly Ser His Gln Leu Pro 290 295 300Arg Gly Tyr Ile Ser Ile Pro Val
Ile His Glu Gln Asn Val Thr Arg305 310 315 320Pro Ala Ala Gln Pro
Ser Phe His Lys Ala Gln Lys Thr His Tyr Pro 325 330 335Ala Gln Arg
Gly Glu Tyr Gln Thr His Gln Pro Val Tyr His Lys Ile 340 345 350Gln
Gly Asp Asp Trp Glu Pro Arg Pro Leu Arg Ala Ala Ser Pro Phe 355 360
365Arg Ser Ser Val Gln Gly Ala Ser Ser Arg Glu Gly Ser Pro Ala Arg
370 375 380Ser Ser Thr Pro Leu His Ser Pro Ser Pro Ile Arg Val His
Thr Val385 390 395 400Val Asp Arg Pro Gln Gln Pro Met Thr His Arg
Glu Thr Ala Pro Val 405 410 415Ser Gln Pro Glu Asn Lys Pro Glu Ser
Lys Pro Gly Pro Val Gly Pro 420 425 430Glu Leu Pro Pro Gly His Ile
Pro Ile Gln Val Ile Arg Lys Glu Val 435 440 445Asp Ser Lys Pro Val
Ser Gln Lys Pro Pro Pro Pro Ser Glu Lys Val 450 455 460Glu Val Lys
Val Pro Pro Ala Pro Val Pro Cys Pro Pro Pro Ser Pro465 470 475
480Gly Pro Ser Ala Val Pro Ser Ser Pro Lys Ser Val Ala Thr Glu Glu
485 490 495Arg Ala Ala Pro Ser Thr Ala Pro Ala Glu Ala Thr Pro Pro
Lys Pro 500 505 510Gly Glu Ala Glu Ala Pro Pro Lys His Pro Gly Val
Leu Lys Val Glu 515 520 525Ala Ile Leu Glu Lys Val Gln Gly Leu Glu
Gln Ala Val Asp Asn Phe 530 535 540Glu Gly Lys Lys Thr Asp Lys Lys
Tyr Leu Met Ile Glu Glu Tyr Leu545 550 555 560Thr Lys Glu Leu Leu
Ala Leu Asp Ser Val Asp Pro Glu Gly Arg Ala 565 570 575Asp Val Arg
Gln Ala Arg Arg Asp Gly Val Arg Lys Val Gln Thr Ile 580 585 590Leu
Glu Lys Leu Glu Gln Lys Ala Ile Asp Val Pro Gly Gln Val Gln 595 600
605Val Tyr Glu Leu Gln Pro Ser Asn Leu Glu Ala Asp Gln Pro Leu Gln
610 615 620Ala Ile Met Glu Met Gly Ala Val Ala Ala Asp Lys Gly Lys
Lys Asn625 630 635 640Ala Gly Asn Ala Glu Asp Pro His Thr Glu Thr
Gln Gln Pro Glu Ala 645 650 655Thr Ala Ala Ala Thr Ser Asn Pro Ser
Ser Met Thr Asp Thr Pro Gly 660 665 670Asn Pro Ala Ala Pro
67571010DNAHomo sapiensCDS(323)..(1009) 7acgatatcct gtaagaccaa
gaattgcaag gccagagttt gaattcttat acaaatggag 60cgtatggtcc aacatacccc
ccaggccctg gggcaaatac tgcctcatac tcaggggctt 120attatgcacc
tggttatact cagaccagtt actccacaga agttccaagt acttaccgtt
180catctggcaa cagcccaact ccagtctctc gttggatcta tccccagcag
gactgtcaag 240actgaagcac cccctcttaa ggggcaggtt ccaggatatc
cgccttcaca gaaccctgga 300atgaccctgc cccattatcc tt atg gag atg gta
atc gta gtg ttc cac aat 352 Met Glu Met Val Ile Val Val Phe His Asn
1 5 10cac ggc cga ctg tac gac cac aag aaa gat gcg tgg gct tct cct
ggt 400His Gly Arg Leu Tyr Asp His Lys Lys Asp Ala Trp Ala Ser Pro
Gly 15 20 25gct tat gga atg ggt ggc cgt tat ccc tgg cct tca tca gcg
ccc tca 448Ala Tyr Gly Met Gly Gly Arg Tyr Pro Trp Pro Ser Ser Ala
Pro Ser 30 35 40gca cca ccc ggc aat ctc tac atg act gaa agt act tca
cca tgg cct 496Ala Pro Pro Gly Asn Leu Tyr Met Thr Glu Ser Thr Ser
Pro Trp Pro 45 50 55agc agt ggc tct ccc cag tca ccc cct tca ccc cca
gtc cag cag ccc 544Ser Ser Gly Ser Pro Gln Ser Pro Pro Ser Pro Pro
Val Gln Gln Pro 60 65 70aag gat tct tca tac ccc tat agc caa tca gat
caa agc atg aac cgg 592Lys Asp Ser Ser Tyr Pro Tyr Ser Gln Ser Asp
Gln Ser Met Asn Arg75 80 85 90cac aac ttt cct tgc agt gtc cat cag
tac gaa tcc tcg ggg aca gtg 640His Asn Phe Pro Cys Ser Val His Gln
Tyr Glu Ser Ser Gly Thr Val 95 100 105aac aat gat gat tca gat ctt
ttg gat tcc caa gtc cag tat agt gct 688Asn Asn Asp Asp Ser Asp Leu
Leu Asp Ser Gln Val Gln Tyr Ser Ala 110 115 120gag cct cag ctg tat
ggt aat gcc acc agt gac cat ccc aac aat caa 736Glu Pro Gln Leu Tyr
Gly Asn Ala Thr Ser Asp His Pro Asn Asn Gln 125 130 135gat caa agt
agc agt ctt cct gaa gaa tgt gta cct tca gat gaa agt 784Asp Gln Ser
Ser Ser Leu Pro Glu Glu Cys Val Pro Ser Asp Glu Ser 140 145 150act
cct ccg agt att aaa aaa atc ata cat gtg ctg gag aag gtc cag 832Thr
Pro Pro Ser Ile Lys Lys Ile Ile His Val Leu Glu Lys Val Gln155 160
165 170tat ctt gaa caa gaa gta gaa gaa ttt gta gga aaa aag aca gac
aaa 880Tyr Leu Glu Gln Glu Val Glu Glu Phe Val Gly Lys Lys Thr Asp
Lys 175 180 185gca tac tgg ctt ctg gaa gaa atg cta acc aag gaa ctt
ttg gaa ctg 928Ala Tyr Trp Leu Leu Glu Glu Met Leu Thr Lys Glu Leu
Leu Glu Leu 190 195 200gat tca gtt gaa act ggg ggc cag gac tct gta
cgg cag gcc aga aaa 976Asp Ser Val Glu Thr Gly Gly Gln Asp Ser Val
Arg Gln Ala Arg Lys 205 210 215gag gct gtt tgt aag att cag gcc ata
ttg gaa a 1010Glu Ala Val Cys Lys Ile Gln Ala Ile Leu Glu 220
2258229PRTHomo sapiens 8Met Glu Met Val Ile Val Val Phe His Asn His
Gly Arg Leu Tyr Asp1 5 10 15His Lys Lys Asp Ala Trp Ala Ser Pro Gly
Ala Tyr Gly Met Gly Gly 20 25 30Arg Tyr Pro Trp Pro Ser Ser Ala Pro
Ser Ala Pro Pro Gly Asn Leu 35 40 45Tyr Met Thr Glu Ser Thr Ser Pro
Trp Pro Ser Ser Gly Ser Pro Gln 50 55 60Ser Pro Pro Ser Pro Pro Val
Gln Gln Pro Lys Asp Ser Ser Tyr Pro65 70 75 80Tyr Ser Gln Ser Asp
Gln Ser Met Asn Arg His Asn Phe Pro Cys Ser 85 90 95Val His Gln Tyr
Glu Ser Ser Gly Thr Val Asn Asn Asp Asp Ser Asp 100 105 110Leu Leu
Asp Ser Gln Val Gln Tyr Ser Ala Glu Pro Gln Leu Tyr Gly 115 120
125Asn Ala Thr Ser Asp His Pro Asn Asn Gln Asp Gln Ser Ser Ser Leu
130 135 140Pro Glu Glu Cys Val Pro Ser Asp Glu Ser Thr Pro Pro Ser
Ile Lys145 150 155 160Lys Ile Ile His Val Leu Glu Lys Val Gln Tyr
Leu Glu Gln Glu Val 165 170 175Glu Glu Phe Val Gly Lys Lys Thr Asp
Lys Ala Tyr Trp Leu Leu Glu 180 185 190Glu Met Leu Thr Lys Glu Leu
Leu Glu Leu Asp Ser Val Glu Thr Gly 195 200 205Gly Gln Asp Ser Val
Arg Gln Ala Arg Lys Glu Ala Val Cys Lys Ile 210 215 220Gln Ala Ile
Leu Glu2259689DNAHomo sapiensCDS(3)..(482)unsure(105)any amino acid
9ga gaa ata aaa aat gaa ctt ctc caa gca caa aac cct tct gaa ttg 47
Glu Ile Lys Asn Glu Leu Leu Gln Ala Gln Asn Pro Ser Glu Leu 1 5 10
15tac ctg agc tcc aaa aca gaa ttg cag ggt tta att gga cag ttg gat
95Tyr Leu Ser Ser Lys Thr Glu Leu Gln Gly Leu Ile Gly Gln Leu Asp
20 25 30gag gta agt ntt gaa aaa aac ccc tgc atc cgg gaa gcc agg aga
aga 143Glu Val Ser Xaa Glu Lys Asn Pro Cys Ile Arg Glu Ala Arg Arg
Arg 35 40 45gca gtg atc gag gtg caa act ctg atc aca tat att gac ttg
aag gag 191Ala Val Ile Glu Val Gln Thr Leu Ile Thr Tyr Ile Asp Leu
Lys Glu 50 55 60gcc ctt gag aaa aga aag ctg ttt gct tgt gag gag cac
cca tcc cat 239Ala Leu Glu Lys Arg Lys Leu Phe Ala Cys Glu Glu His
Pro Ser His 65 70 75aaa gcc gtc tgg aac gtc ctt gga aac ttg tct gag
atc cag gga gaa 287Lys Ala Val Trp Asn Val Leu Gly Asn Leu Ser Glu
Ile Gln Gly Glu80 85 90 95gtt ctt tca ttt gat gga aat cga acc gat
aag aac tac atc cgg ctg 335Val Leu Ser Phe Asp Gly Asn Arg Thr Asp
Lys Asn Tyr Ile Arg Leu 100 105 110gaa gag ctg ctc acc aag cag ctg
cta gcc ctg gat gct gtt gat ccg 383Glu Glu Leu Leu Thr Lys Gln Leu
Leu Ala Leu Asp Ala Val Asp Pro 115 120 125cag gga gaa gag aag tgt
aag gct gcc agg aaa caa gct gtg agg ctt 431Gln Gly Glu Glu Lys Cys
Lys Ala Ala Arg Lys Gln Ala Val Arg Leu 130 135 140gcg cag aat att
ctc agc tat ctc gac ctg aaa tct gat gaa tgg gag 479Ala Gln Asn Ile
Leu Ser Tyr Leu Asp Leu Lys Ser Asp Glu Trp Glu 145 150 155tac
tgaaatacca gagatctcac ttttgatact gttttgcact tcatatgtgc
532Tyr160ttctatgtat agagagcttt cagttcattg atttatacgt gcatatttca
gtctcagtat 592ttatgattga agcaaattct attcagtatc tgctgctttt
gatgttgcaa gacaaatatc 652attacagcac gttaactttt ccattcggat caaaaaa
68910160PRTHomo sapiensunsure1..160Xaa=any amino acid 10Glu Ile Lys
Asn Glu Leu Leu Gln Ala Gln Asn Pro Ser Glu Leu Tyr1 5 10 15Leu Ser
Ser Lys Thr Glu Leu Gln Gly Leu Ile Gly Gln Leu Asp Glu 20 25 30Val
Ser Xaa Glu Lys Asn Pro Cys Ile Arg Glu Ala Arg Arg Arg Ala 35 40
45Val Ile Glu Val Gln Thr Leu Ile Thr Tyr Ile Asp Leu Lys Glu Ala
50 55 60Leu Glu Lys Arg Lys Leu Phe Ala Cys Glu Glu His Pro Ser His
Lys65 70 75 80Ala Val Trp Asn Val Leu Gly Asn Leu Ser Glu Ile Gln
Gly Glu Val 85 90 95Leu Ser Phe Asp Gly Asn Arg Thr Asp Lys Asn Tyr
Ile Arg Leu Glu 100 105 110Glu Leu Leu Thr Lys Gln Leu Leu Ala Leu
Asp Ala Val Asp Pro Gln 115 120 125Gly Glu Glu Lys Cys Lys Ala Ala
Arg Lys Gln Ala Val Arg Leu Ala 130 135 140Gln Asn Ile Leu Ser Tyr
Leu Asp Leu Lys Ser Asp Glu Trp Glu Tyr145 150 155
16011246DNACaenorhabditis elegans 11atgtctttcc gcctcttcgt
tgaaatattt cactttcttt tccagctttt tccccatctc 60gacctgcttt ggtttttcga
gaaaaccacg ttccaaatca gcgacatctc tcaaattgag 120atcataggct
ttttgaagat tgctcaaatt atgcttctca tattgcatga gcattttgaa
180gcccgcgtca tcaaccaaag cattttttcc acccatcaca atgattttat
cattttcttt 240aaaatt 24612210PRTCaenorhabditis elegans 12Met Lys
Val Asn Val Ser Cys Ser Ser Val Gln Thr Thr Ile Asp Ile1 5 10 15Leu
Glu Glu Asn Gln Gly Glu Asp Glu Ser Ile Leu Thr Leu Gly Gln 20 25
30Leu Arg Asp Arg Ile Ala Thr Asp Asn Asp Val Asp Val Glu Thr Met
35 40 45Lys Leu Leu His Arg Gly Lys Phe Leu Gln Gly Ala Asp Asp Val
Ser 50 55 60Leu Ser Thr Leu Asn Phe Lys Glu Asn Asp Lys Ile Ile Val
Met Gly65 70 75 80Gly Lys Asn Ala Leu Val Asp Asp Ala Gly Phe Lys
Met Leu Met Gln 85 90 95Tyr Glu Lys His Asn Leu Ser Asn Leu Gln Lys
Ala Tyr Asp Leu Asn 100 105 110Leu Arg Asp Val Ala Asp Leu Glu Arg
Gly Phe Leu Glu Lys Pro Lys 115 120 125Gln Val Glu Met Gly Lys Lys
Leu Glu Lys Lys Val Lys Tyr Phe Asn 130 135 140Glu Glu Ala Glu Arg
His Leu Glu Thr Leu Asp Gly Met Asn Ile Ile145 150 155 160Thr Glu
Thr Thr Pro Glu Asn Gln Ala Lys Arg Asn Arg Glu Lys Arg 165 170
175Lys Thr Leu Val Asn Gly Ile Gln Thr Leu Leu Asn Gln Asn Asp Ala
180 185 190Leu Leu Arg Arg Leu Gln Glu Tyr Gln Ser Val Leu Asn Gly
Asp Ile 195 200 205Pro Glu 210131377DNACaenorhabditis
elegansCDS(1)..(1377) 13atg cca gtc gtg aac ata cca atc aaa ata ctt
ggt cag aat caa tca 48Met Pro Val Val Asn Ile Pro Ile Lys Ile Leu
Gly Gln Asn Gln Ser1 5 10 15cat agt cga agt aac tcc tcg tct tct gtt
gac aac gat cga aat caa 96His Ser Arg Ser Asn Ser Ser Ser Ser Val
Asp
Asn Asp Arg Asn Gln 20 25 30cca cca cag cag cca cct caa ccg caa cca
caa cag caa tct cag caa 144Pro Pro Gln Gln Pro Pro Gln Pro Gln Pro
Gln Gln Gln Ser Gln Gln 35 40 45caa tac cag cag gct cca aac gtg aat
acc aat atg cat cat tcc aac 192Gln Tyr Gln Gln Ala Pro Asn Val Asn
Thr Asn Met His His Ser Asn 50 55 60gga ttc tca cct aac ttc cca tct
cgt agt cct att ccg gac ttt ccc 240Gly Phe Ser Pro Asn Phe Pro Ser
Arg Ser Pro Ile Pro Asp Phe Pro65 70 75 80agt ttt tca tct ggg ttc
cca aac gat tct gaa tgg tct tcg aat ttc 288Ser Phe Ser Ser Gly Phe
Pro Asn Asp Ser Glu Trp Ser Ser Asn Phe 85 90 95ccg tcg ttt cca aat
ttc cca agt gga ttc tca aat gga agt tct aat 336Pro Ser Phe Pro Asn
Phe Pro Ser Gly Phe Ser Asn Gly Ser Ser Asn 100 105 110ttc cct gat
ttt cca aga ttc gga aga gat gga gga cta tcg cca aac 384Phe Pro Asp
Phe Pro Arg Phe Gly Arg Asp Gly Gly Leu Ser Pro Asn 115 120 125cca
ccg atg caa gga tac agg aga agt cca aca cca aca tca act caa 432Pro
Pro Met Gln Gly Tyr Arg Arg Ser Pro Thr Pro Thr Ser Thr Gln 130 135
140tct cca act tct aca tta aga cgc aac tct cag cag aat caa gct cct
480Ser Pro Thr Ser Thr Leu Arg Arg Asn Ser Gln Gln Asn Gln Ala
Pro145 150 155 160cca caa tat tct cag caa caa cca caa caa gct caa
caa cgt cag aca 528Pro Gln Tyr Ser Gln Gln Gln Pro Gln Gln Ala Gln
Gln Arg Gln Thr 165 170 175act cct ccg tca aca aaa gct tca tct cga
cca cca tct cgt act cgt 576Thr Pro Pro Ser Thr Lys Ala Ser Ser Arg
Pro Pro Ser Arg Thr Arg 180 185 190gaa cca aag gaa cct gag gta ccc
gag aga cca gca gtt att cca ttg 624Glu Pro Lys Glu Pro Glu Val Pro
Glu Arg Pro Ala Val Ile Pro Leu 195 200 205cca tat gag aag aag gag
aaa cca ctg gag aag aaa ggt agt cgt gat 672Pro Tyr Glu Lys Lys Glu
Lys Pro Leu Glu Lys Lys Gly Ser Arg Asp 210 215 220tct gga aag ggt
gat gag aac ctt gaa gag aac att gcc aag atc acg 720Ser Gly Lys Gly
Asp Glu Asn Leu Glu Glu Asn Ile Ala Lys Ile Thr225 230 235 240atc
gga aag aat aat tgc gag tta tgt ccg gaa caa gaa acg gac ggc 768Ile
Gly Lys Asn Asn Cys Glu Leu Cys Pro Glu Gln Glu Thr Asp Gly 245 250
255gac cca tct cca cta acc tcc cca atc acc gaa gga aag cca aag aga
816Asp Pro Ser Pro Leu Thr Ser Pro Ile Thr Glu Gly Lys Pro Lys Arg
260 265 270gga aag aaa ctt caa cgt aat caa agt gtt gtt gat ttc aat
gcc aag 864Gly Lys Lys Leu Gln Arg Asn Gln Ser Val Val Asp Phe Asn
Ala Lys 275 280 285aca att gtt act ttg gat aaa att gaa tta caa gtt
gag cag ttg aga 912Thr Ile Val Thr Leu Asp Lys Ile Glu Leu Gln Val
Glu Gln Leu Arg 290 295 300aaa aaa gct gct gaa ctc gaa atg gaa aaa
gag caa att ctt cgt tct 960Lys Lys Ala Ala Glu Leu Glu Met Glu Lys
Glu Gln Ile Leu Arg Ser305 310 315 320cta gga gaa atc agt gtt cat
aac tgc atg ttc aaa ctg gaa gaa tgt 1008Leu Gly Glu Ile Ser Val His
Asn Cys Met Phe Lys Leu Glu Glu Cys 325 330 335gat cgt gaa gag att
gaa gca atc act gac cga ttg aca aaa aga aca 1056Asp Arg Glu Glu Ile
Glu Ala Ile Thr Asp Arg Leu Thr Lys Arg Thr 340 345 350aag aca gtt
caa gtt gtt gtc gaa act cca cga aat gaa gaa cag aaa 1104Lys Thr Val
Gln Val Val Val Glu Thr Pro Arg Asn Glu Glu Gln Lys 355 360 365aaa
gca ctg gaa gat gca act ttg atg atc gat gaa gtc gga gaa atg 1152Lys
Ala Leu Glu Asp Ala Thr Leu Met Ile Asp Glu Val Gly Glu Met 370 375
380atg cat tcg aat att gaa aag gct aag ctg tgc cta caa acc tac atg
1200Met His Ser Asn Ile Glu Lys Ala Lys Leu Cys Leu Gln Thr Tyr
Met385 390 395 400aac gcc tgt tcg tac gaa gaa act gct gga gcc acc
tgc caa aac ttc 1248Asn Ala Cys Ser Tyr Glu Glu Thr Ala Gly Ala Thr
Cys Gln Asn Phe 405 410 415ttg aag atc ata att cag tgc gct gct gat
gat cag aaa cgc atc aag 1296Leu Lys Ile Ile Ile Gln Cys Ala Ala Asp
Asp Gln Lys Arg Ile Lys 420 425 430cgt cgt ctg gaa aat ctg atg tct
caa att gag aat gct gag aga acg 1344Arg Arg Leu Glu Asn Leu Met Ser
Gln Ile Glu Asn Ala Glu Arg Thr 435 440 445aaa gca gat ttg atg gat
gat caa agc gaa tag 1377Lys Ala Asp Leu Met Asp Asp Gln Ser Glu 450
45514458PRTCaenorhabditis elegans 14Met Pro Val Val Asn Ile Pro Ile
Lys Ile Leu Gly Gln Asn Gln Ser1 5 10 15His Ser Arg Ser Asn Ser Ser
Ser Ser Val Asp Asn Asp Arg Asn Gln 20 25 30Pro Pro Gln Gln Pro Pro
Gln Pro Gln Pro Gln Gln Gln Ser Gln Gln 35 40 45Gln Tyr Gln Gln Ala
Pro Asn Val Asn Thr Asn Met His His Ser Asn 50 55 60Gly Phe Ser Pro
Asn Phe Pro Ser Arg Ser Pro Ile Pro Asp Phe Pro65 70 75 80Ser Phe
Ser Ser Gly Phe Pro Asn Asp Ser Glu Trp Ser Ser Asn Phe 85 90 95Pro
Ser Phe Pro Asn Phe Pro Ser Gly Phe Ser Asn Gly Ser Ser Asn 100 105
110Phe Pro Asp Phe Pro Arg Phe Gly Arg Asp Gly Gly Leu Ser Pro Asn
115 120 125Pro Pro Met Gln Gly Tyr Arg Arg Ser Pro Thr Pro Thr Ser
Thr Gln 130 135 140Ser Pro Thr Ser Thr Leu Arg Arg Asn Ser Gln Gln
Asn Gln Ala Pro145 150 155 160Pro Gln Tyr Ser Gln Gln Gln Pro Gln
Gln Ala Gln Gln Arg Gln Thr 165 170 175Thr Pro Pro Ser Thr Lys Ala
Ser Ser Arg Pro Pro Ser Arg Thr Arg 180 185 190Glu Pro Lys Glu Pro
Glu Val Pro Glu Arg Pro Ala Val Ile Pro Leu 195 200 205Pro Tyr Glu
Lys Lys Glu Lys Pro Leu Glu Lys Lys Gly Ser Arg Asp 210 215 220Ser
Gly Lys Gly Asp Glu Asn Leu Glu Glu Asn Ile Ala Lys Ile Thr225 230
235 240Ile Gly Lys Asn Asn Cys Glu Leu Cys Pro Glu Gln Glu Thr Asp
Gly 245 250 255Asp Pro Ser Pro Leu Thr Ser Pro Ile Thr Glu Gly Lys
Pro Lys Arg 260 265 270Gly Lys Lys Leu Gln Arg Asn Gln Ser Val Val
Asp Phe Asn Ala Lys 275 280 285Thr Ile Val Thr Leu Asp Lys Ile Glu
Leu Gln Val Glu Gln Leu Arg 290 295 300Lys Lys Ala Ala Glu Leu Glu
Met Glu Lys Glu Gln Ile Leu Arg Ser305 310 315 320Leu Gly Glu Ile
Ser Val His Asn Cys Met Phe Lys Leu Glu Glu Cys 325 330 335Asp Arg
Glu Glu Ile Glu Ala Ile Thr Asp Arg Leu Thr Lys Arg Thr 340 345
350Lys Thr Val Gln Val Val Val Glu Thr Pro Arg Asn Glu Glu Gln Lys
355 360 365Lys Ala Leu Glu Asp Ala Thr Leu Met Ile Asp Glu Val Gly
Glu Met 370 375 380Met His Ser Asn Ile Glu Lys Ala Lys Leu Cys Leu
Gln Thr Tyr Met385 390 395 400Asn Ala Cys Ser Tyr Glu Glu Thr Ala
Gly Ala Thr Cys Gln Asn Phe 405 410 415Leu Lys Ile Ile Ile Gln Cys
Ala Ala Asp Asp Gln Lys Arg Ile Lys 420 425 430Arg Arg Leu Glu Asn
Leu Met Ser Gln Ile Glu Asn Ala Glu Arg Thr 435 440 445Lys Ala Asp
Leu Met Asp Asp Gln Ser Glu 450 45515588DNASchizosaccharomyces
pombeCDS(1)..(588) 15atg tca gaa aag act agc aca gtt aca ata cac
tat gga aat cag cga 48Met Ser Glu Lys Thr Ser Thr Val Thr Ile His
Tyr Gly Asn Gln Arg1 5 10 15ttt ccg gta gca gtc aat cta aat gag acg
tta agt gaa ctg att gat 96Phe Pro Val Ala Val Asn Leu Asn Glu Thr
Leu Ser Glu Leu Ile Asp 20 25 30gat tta ctt gaa acg act gag att tct
gag aag aaa gtc aag ctt ttt 144Asp Leu Leu Glu Thr Thr Glu Ile Ser
Glu Lys Lys Val Lys Leu Phe 35 40 45tac gct ggc aag cgt tta aaa gac
aaa aaa gcc tcg tta tca aaa ttg 192Tyr Ala Gly Lys Arg Leu Lys Asp
Lys Lys Ala Ser Leu Ser Lys Leu 50 55 60ggt tta aaa aat cat agt aaa
att cta tgt ata aga cca cat aag caa 240Gly Leu Lys Asn His Ser Lys
Ile Leu Cys Ile Arg Pro His Lys Gln65 70 75 80caa cga ggt tcc aag
gaa aaa gac acg gtt gag ccc gct ccg aaa gcg 288Gln Arg Gly Ser Lys
Glu Lys Asp Thr Val Glu Pro Ala Pro Lys Ala 85 90 95gaa gcg gag aat
cct gta ttt tcg cgt att tct gga gaa ata aaa gcc 336Glu Ala Glu Asn
Pro Val Phe Ser Arg Ile Ser Gly Glu Ile Lys Ala 100 105 110atc gat
cag tat gtt gac aaa gaa ctt tcc ccc atg tac gac aat tac 384Ile Asp
Gln Tyr Val Asp Lys Glu Leu Ser Pro Met Tyr Asp Asn Tyr 115 120
125gta aat aaa ccg tcg aac gat cca aag cag aaa aac aaa cag aaa cta
432Val Asn Lys Pro Ser Asn Asp Pro Lys Gln Lys Asn Lys Gln Lys Leu
130 135 140atg ata agt gaa cta ctt tta caa cag ctt tta aaa ttg gat
gga gtt 480Met Ile Ser Glu Leu Leu Leu Gln Gln Leu Leu Lys Leu Asp
Gly Val145 150 155 160gac gta ctg ggc agc gag aaa ttg cgt ttt gaa
cgg aag caa ctt gtt 528Asp Val Leu Gly Ser Glu Lys Leu Arg Phe Glu
Arg Lys Gln Leu Val 165 170 175tct aag atc caa aaa atg ttg gat cac
gtt gac caa aca agc caa gaa 576Ser Lys Ile Gln Lys Met Leu Asp His
Val Asp Gln Thr Ser Gln Glu 180 185 190gtg gcc gca tag 588Val Ala
Ala 19516195PRTSchizosaccharomyces pombe 16Met Ser Glu Lys Thr Ser
Thr Val Thr Ile His Tyr Gly Asn Gln Arg1 5 10 15Phe Pro Val Ala Val
Asn Leu Asn Glu Thr Leu Ser Glu Leu Ile Asp 20 25 30Asp Leu Leu Glu
Thr Thr Glu Ile Ser Glu Lys Lys Val Lys Leu Phe 35 40 45Tyr Ala Gly
Lys Arg Leu Lys Asp Lys Lys Ala Ser Leu Ser Lys Leu 50 55 60Gly Leu
Lys Asn His Ser Lys Ile Leu Cys Ile Arg Pro His Lys Gln65 70 75
80Gln Arg Gly Ser Lys Glu Lys Asp Thr Val Glu Pro Ala Pro Lys Ala
85 90 95Glu Ala Glu Asn Pro Val Phe Ser Arg Ile Ser Gly Glu Ile Lys
Ala 100 105 110Ile Asp Gln Tyr Val Asp Lys Glu Leu Ser Pro Met Tyr
Asp Asn Tyr 115 120 125Val Asn Lys Pro Ser Asn Asp Pro Lys Gln Lys
Asn Lys Gln Lys Leu 130 135 140Met Ile Ser Glu Leu Leu Leu Gln Gln
Leu Leu Lys Leu Asp Gly Val145 150 155 160Asp Val Leu Gly Ser Glu
Lys Leu Arg Phe Glu Arg Lys Gln Leu Val 165 170 175Ser Lys Ile Gln
Lys Met Leu Asp His Val Asp Gln Thr Ser Gln Glu 180 185 190Val Ala
Ala 19517621DNASchizosaccharomyces pombeCDS(1)..(621) 17atg tct ttt
ttt acc cag ttg tgt tct atg gat aaa aaa tat tgg atc 48Met Ser Phe
Phe Thr Gln Leu Cys Ser Met Asp Lys Lys Tyr Trp Ile1 5 10 15tct cta
gct gta ttg tca gtt act gtt ttg att agc gca tta ttg aaa 96Ser Leu
Ala Val Leu Ser Val Thr Val Leu Ile Ser Ala Leu Leu Lys 20 25 30aag
aga gct act gaa acc gaa gat att gtc gtt gtt cat tac gat ggc 144Lys
Arg Ala Thr Glu Thr Glu Asp Ile Val Val Val His Tyr Asp Gly 35 40
45gaa aag ttg aat ttt gtg ttg cga caa cca agg ctg aat atg gtt tct
192Glu Lys Leu Asn Phe Val Leu Arg Gln Pro Arg Leu Asn Met Val Ser
50 55 60tac act agt ttt ctt cgt cgc gtg tgc aac gca ttt tca gta atg
ccc 240Tyr Thr Ser Phe Leu Arg Arg Val Cys Asn Ala Phe Ser Val Met
Pro65 70 75 80gac aaa gcg tct ctc aag tta aac ggg gtg acc ctc aag
gat ggt tca 288Asp Lys Ala Ser Leu Lys Leu Asn Gly Val Thr Leu Lys
Asp Gly Ser 85 90 95ctt tcc gac caa aat gtg caa aat gga agt gaa tta
gag ctc gaa tta 336Leu Ser Asp Gln Asn Val Gln Asn Gly Ser Glu Leu
Glu Leu Glu Leu 100 105 110ccc aaa ctg agc ccg gca atg caa caa att
gaa gca tat ata gat gag 384Pro Lys Leu Ser Pro Ala Met Gln Gln Ile
Glu Ala Tyr Ile Asp Glu 115 120 125ctt caa cag gat ctc gtc cct aaa
att gaa gcc ttc tgc caa tcg tct 432Leu Gln Gln Asp Leu Val Pro Lys
Ile Glu Ala Phe Cys Gln Ser Ser 130 135 140ccc gct tcg gca caa gat
gtt caa gat ttg cat aca cgc ctt agt gaa 480Pro Ala Ser Ala Gln Asp
Val Gln Asp Leu His Thr Arg Leu Ser Glu145 150 155 160aca ttg ttg
gct agg atg ata aaa tta gat gct gtt aat gtt gaa gac 528Thr Leu Leu
Ala Arg Met Ile Lys Leu Asp Ala Val Asn Val Glu Asp 165 170 175gac
cca gaa gct cgt ctt aaa aga aaa gaa gct att cgt tta tct caa 576Asp
Pro Glu Ala Arg Leu Lys Arg Lys Glu Ala Ile Arg Leu Ser Gln 180 185
190caa tat ttg agt aaa cta gat tcc acc aag aat caa aac aaa tga
621Gln Tyr Leu Ser Lys Leu Asp Ser Thr Lys Asn Gln Asn Lys 195 200
20518206PRTSchizosaccharomyces pombe 18Met Ser Phe Phe Thr Gln Leu
Cys Ser Met Asp Lys Lys Tyr Trp Ile1 5 10 15Ser Leu Ala Val Leu Ser
Val Thr Val Leu Ile Ser Ala Leu Leu Lys 20 25 30Lys Arg Ala Thr Glu
Thr Glu Asp Ile Val Val Val His Tyr Asp Gly 35 40 45Glu Lys Leu Asn
Phe Val Leu Arg Gln Pro Arg Leu Asn Met Val Ser 50 55 60Tyr Thr Ser
Phe Leu Arg Arg Val Cys Asn Ala Phe Ser Val Met Pro65 70 75 80Asp
Lys Ala Ser Leu Lys Leu Asn Gly Val Thr Leu Lys Asp Gly Ser 85 90
95Leu Ser Asp Gln Asn Val Gln Asn Gly Ser Glu Leu Glu Leu Glu Leu
100 105 110Pro Lys Leu Ser Pro Ala Met Gln Gln Ile Glu Ala Tyr Ile
Asp Glu 115 120 125Leu Gln Gln Asp Leu Val Pro Lys Ile Glu Ala Phe
Cys Gln Ser Ser 130 135 140Pro Ala Ser Ala Gln Asp Val Gln Asp Leu
His Thr Arg Leu Ser Glu145 150 155 160Thr Leu Leu Ala Arg Met Ile
Lys Leu Asp Ala Val Asn Val Glu Asp 165 170 175Asp Pro Glu Ala Arg
Leu Lys Arg Lys Glu Ala Ile Arg Leu Ser Gln 180 185 190Gln Tyr Leu
Ser Lys Leu Asp Ser Thr Lys Asn Gln Asn Lys 195 200
205192534DNAHomo sapiensCDS(307)..(2034) 19gcggagctcc gcatccaacc
ccgggccgcg gccaacttct ctggactgga ccagaagttt 60ctagccggcc agttgctacc
tccctttatc tcctccttcc cctctggcag cgaggaggct 120atttccagac
acttccaccc ctctctggcc acgtcacccc cgcctttaat tcataaaggt
180gcccggcgcc ggcttcccgg acacgtcggc ggcggagagg ggcccacggc
ggcggcccgg 240ccagagactc ggcgcccgga gccagcgccc cgcacccgcg
ccccagcggg cagaccccaa 300cccagc atg agc gcc gcc acc cac tcg ccc atg
atg cag gtg gcg tcc 348 Met Ser Ala Ala Thr His Ser Pro Met Met Gln
Val Ala Ser 1 5 10ggc aac ggt gac cgc gac cct ttg ccc ccc gga tgg
gag atc aag atc 396Gly Asn Gly Asp Arg Asp Pro Leu Pro Pro Gly Trp
Glu Ile Lys Ile15 20 25 30gac ccg cag acc ggc tgg ccc ttc ttc gtg
gac cac aac agc cgc acc 444Asp Pro Gln Thr Gly Trp Pro Phe Phe Val
Asp His Asn Ser Arg Thr 35 40 45act acg tgg aac gac ccg cgc gtg ccc
tct gag ggc ccc aag gag act 492Thr Thr Trp Asn Asp Pro Arg Val Pro
Ser Glu Gly Pro Lys Glu Thr 50 55 60cca tcc tct gcc aat ggc cct tcc
cgg gag ggc tct agg ctg ccg cct 540Pro Ser Ser Ala Asn Gly Pro Ser
Arg Glu Gly Ser Arg Leu Pro Pro 65 70 75gct agg gaa ggc cac cct gtg
tac ccc cag ctc cga cca ggc tac att 588Ala Arg Glu Gly His Pro Val
Tyr Pro Gln Leu Arg Pro Gly Tyr Ile 80 85 90ccc att cct gtg ctc cat
gaa ggc gct gag aac cgg cag gtg cac cct 636Pro Ile Pro Val Leu His
Glu Gly Ala Glu Asn Arg Gln Val His Pro95 100 105 110ttc cat gtc
tat ccc
cag cct ggg atg cag cga ttc cga act gag gcg 684Phe His Val Tyr Pro
Gln Pro Gly Met Gln Arg Phe Arg Thr Glu Ala 115 120 125gca gca gcg
gct cct cag agg tcc cag tca cct ctg cgg ggc atg cca 732Ala Ala Ala
Ala Pro Gln Arg Ser Gln Ser Pro Leu Arg Gly Met Pro 130 135 140gaa
acc act cag cca gat aaa cag tgt gga cag gtg gca gcg gcg gcg 780Glu
Thr Thr Gln Pro Asp Lys Gln Cys Gly Gln Val Ala Ala Ala Ala 145 150
155gca gcc cag ccc cca gcc tcc cac gga cct gag cgg tcc cag tct cca
828Ala Ala Gln Pro Pro Ala Ser His Gly Pro Glu Arg Ser Gln Ser Pro
160 165 170gct gcc tct gac tgc tca tcc tca tcc tcc tcg gcc agc ctg
cct tcc 876Ala Ala Ser Asp Cys Ser Ser Ser Ser Ser Ser Ala Ser Leu
Pro Ser175 180 185 190tcc ggc agg agc agc ctg ggc agt cac cag ctc
ccg cgg ggg tac atc 924Ser Gly Arg Ser Ser Leu Gly Ser His Gln Leu
Pro Arg Gly Tyr Ile 195 200 205tcc att ccg gtg ata cac gag cag aac
gtt acc cgg cca gca gcc cag 972Ser Ile Pro Val Ile His Glu Gln Asn
Val Thr Arg Pro Ala Ala Gln 210 215 220ccc tcc ttc cac aaa gcc cag
aag acg cac tac cca gcg cag agg ggt 1020Pro Ser Phe His Lys Ala Gln
Lys Thr His Tyr Pro Ala Gln Arg Gly 225 230 235gag tac cag acc cac
cag cct gtg tac cac aag atc cag ggg gat gac 1068Glu Tyr Gln Thr His
Gln Pro Val Tyr His Lys Ile Gln Gly Asp Asp 240 245 250tgg gag ccc
cgg ccc ctg cgg gcg gca tcc ccg ttc agg tca tct gtc 1116Trp Glu Pro
Arg Pro Leu Arg Ala Ala Ser Pro Phe Arg Ser Ser Val255 260 265
270cag ggt gca tcg agc cgg gag ggc tca cca gcc agg agc agc acg cca
1164Gln Gly Ala Ser Ser Arg Glu Gly Ser Pro Ala Arg Ser Ser Thr Pro
275 280 285ctc cac tcc ccc tcg ccc atc cgt gtg cac acc gtg gtc gac
agg cct 1212Leu His Ser Pro Ser Pro Ile Arg Val His Thr Val Val Asp
Arg Pro 290 295 300cag cag ccc atg acc cat cga gaa act gca cct gtt
tcc cag cct gaa 1260Gln Gln Pro Met Thr His Arg Glu Thr Ala Pro Val
Ser Gln Pro Glu 305 310 315aac aaa cca gaa agt aag cca ggc cca gtt
gga cca gaa ctc cct cct 1308Asn Lys Pro Glu Ser Lys Pro Gly Pro Val
Gly Pro Glu Leu Pro Pro 320 325 330gga cac atc cca att caa gtg atc
cgc aaa gag gtg gat tct aaa cct 1356Gly His Ile Pro Ile Gln Val Ile
Arg Lys Glu Val Asp Ser Lys Pro335 340 345 350gtt tcc cag aag ccc
cca cct ccc tct gag aag gta gag gtg aaa gtt 1404Val Ser Gln Lys Pro
Pro Pro Pro Ser Glu Lys Val Glu Val Lys Val 355 360 365ccc cct gct
cca gtt cct tgt cct cct ccc agc cct ggc cct tct gct 1452Pro Pro Ala
Pro Val Pro Cys Pro Pro Pro Ser Pro Gly Pro Ser Ala 370 375 380gtc
ccc tct tcc ccc aag agt gtg gct aca gaa gag agg gca gcc ccc 1500Val
Pro Ser Ser Pro Lys Ser Val Ala Thr Glu Glu Arg Ala Ala Pro 385 390
395agc act gcc cct gca gaa gct aca cct cca aaa cca gga gaa gcc gag
1548Ser Thr Ala Pro Ala Glu Ala Thr Pro Pro Lys Pro Gly Glu Ala Glu
400 405 410gct ccc cca aaa cat cca gga gtg ctg aaa gtg gaa gcc atc
ctg gag 1596Ala Pro Pro Lys His Pro Gly Val Leu Lys Val Glu Ala Ile
Leu Glu415 420 425 430aag gtg cag ggg ctg gag cag gct gta gac aac
ttt gaa ggc aag aag 1644Lys Val Gln Gly Leu Glu Gln Ala Val Asp Asn
Phe Glu Gly Lys Lys 435 440 445act gac aaa aag tac ctg atg atc gaa
gag tat ttg acc aaa gag ctg 1692Thr Asp Lys Lys Tyr Leu Met Ile Glu
Glu Tyr Leu Thr Lys Glu Leu 450 455 460ctg gcc ctg gat tca gtg gac
ccc gag gga cga gcc gat gtg cgt cag 1740Leu Ala Leu Asp Ser Val Asp
Pro Glu Gly Arg Ala Asp Val Arg Gln 465 470 475gcc agg aga gac ggt
gtc agg aag gtt cag acc atc ttg gaa aaa ctt 1788Ala Arg Arg Asp Gly
Val Arg Lys Val Gln Thr Ile Leu Glu Lys Leu 480 485 490gaa cag aaa
gcc att gat gtc cca ggt caa gtc cag gtc tat gaa ctc 1836Glu Gln Lys
Ala Ile Asp Val Pro Gly Gln Val Gln Val Tyr Glu Leu495 500 505
510cag ccc agc aac ctt gaa gca gat cag cca ctg cag gca atc atg gag
1884Gln Pro Ser Asn Leu Glu Ala Asp Gln Pro Leu Gln Ala Ile Met Glu
515 520 525atg ggt gcc gtg gca gca gac aag ggc aag aaa aat gct gga
aat gca 1932Met Gly Ala Val Ala Ala Asp Lys Gly Lys Lys Asn Ala Gly
Asn Ala 530 535 540gaa gat ccc cac aca gaa acc cag cag cca gaa gcc
aca gca gca gcg 1980Glu Asp Pro His Thr Glu Thr Gln Gln Pro Glu Ala
Thr Ala Ala Ala 545 550 555act tca aac ccc agc agc atg aca gac acc
cct ggt aac cca gca gca 2028Thr Ser Asn Pro Ser Ser Met Thr Asp Thr
Pro Gly Asn Pro Ala Ala 560 565 570ccg tag cctctgccct gtaaaaatca
gactcggaac cgatgtgtgc tttagggaat 2084Pro575tttaagttgc atgcatttca
gagactttaa gtcagttggt ttttattagc tgcttggtat 2144gcagtaactt
gggtggaggc aaaacactaa taaaagggct aaaaaggaaa atgatgcttt
2204tcttctatat tcttactctg tacaaataaa gaagttgctt gttgtttgag
aagtttaacc 2264ccgttgcttg ttctgcagcc ctgtctactt gggcaccccc
accacctgtt agctgtggtt 2324gtgcactgtc ttttgtagct ctggactgga
ggggtagatg gggagtcaat tacccatcac 2384ataaatatga aacatttatc
agaaatgttg ccattttaat gagatgattt tcttcatctc 2444ataattaaaa
tacctgactt tagagagagt aaaatgtgcc aggagccata ggaatatctg
2504tatgttggat gactttaatg ctacattttc 253420575PRTHomo sapiens 20Met
Ser Ala Ala Thr His Ser Pro Met Met Gln Val Ala Ser Gly Asn1 5 10
15Gly Asp Arg Asp Pro Leu Pro Pro Gly Trp Glu Ile Lys Ile Asp Pro
20 25 30Gln Thr Gly Trp Pro Phe Phe Val Asp His Asn Ser Arg Thr Thr
Thr 35 40 45Trp Asn Asp Pro Arg Val Pro Ser Glu Gly Pro Lys Glu Thr
Pro Ser 50 55 60Ser Ala Asn Gly Pro Ser Arg Glu Gly Ser Arg Leu Pro
Pro Ala Arg65 70 75 80Glu Gly His Pro Val Tyr Pro Gln Leu Arg Pro
Gly Tyr Ile Pro Ile 85 90 95Pro Val Leu His Glu Gly Ala Glu Asn Arg
Gln Val His Pro Phe His 100 105 110Val Tyr Pro Gln Pro Gly Met Gln
Arg Phe Arg Thr Glu Ala Ala Ala 115 120 125Ala Ala Pro Gln Arg Ser
Gln Ser Pro Leu Arg Gly Met Pro Glu Thr 130 135 140Thr Gln Pro Asp
Lys Gln Cys Gly Gln Val Ala Ala Ala Ala Ala Ala145 150 155 160Gln
Pro Pro Ala Ser His Gly Pro Glu Arg Ser Gln Ser Pro Ala Ala 165 170
175Ser Asp Cys Ser Ser Ser Ser Ser Ser Ala Ser Leu Pro Ser Ser Gly
180 185 190Arg Ser Ser Leu Gly Ser His Gln Leu Pro Arg Gly Tyr Ile
Ser Ile 195 200 205Pro Val Ile His Glu Gln Asn Val Thr Arg Pro Ala
Ala Gln Pro Ser 210 215 220Phe His Lys Ala Gln Lys Thr His Tyr Pro
Ala Gln Arg Gly Glu Tyr225 230 235 240Gln Thr His Gln Pro Val Tyr
His Lys Ile Gln Gly Asp Asp Trp Glu 245 250 255Pro Arg Pro Leu Arg
Ala Ala Ser Pro Phe Arg Ser Ser Val Gln Gly 260 265 270Ala Ser Ser
Arg Glu Gly Ser Pro Ala Arg Ser Ser Thr Pro Leu His 275 280 285Ser
Pro Ser Pro Ile Arg Val His Thr Val Val Asp Arg Pro Gln Gln 290 295
300Pro Met Thr His Arg Glu Thr Ala Pro Val Ser Gln Pro Glu Asn
Lys305 310 315 320Pro Glu Ser Lys Pro Gly Pro Val Gly Pro Glu Leu
Pro Pro Gly His 325 330 335Ile Pro Ile Gln Val Ile Arg Lys Glu Val
Asp Ser Lys Pro Val Ser 340 345 350Gln Lys Pro Pro Pro Pro Ser Glu
Lys Val Glu Val Lys Val Pro Pro 355 360 365Ala Pro Val Pro Cys Pro
Pro Pro Ser Pro Gly Pro Ser Ala Val Pro 370 375 380Ser Ser Pro Lys
Ser Val Ala Thr Glu Glu Arg Ala Ala Pro Ser Thr385 390 395 400Ala
Pro Ala Glu Ala Thr Pro Pro Lys Pro Gly Glu Ala Glu Ala Pro 405 410
415Pro Lys His Pro Gly Val Leu Lys Val Glu Ala Ile Leu Glu Lys Val
420 425 430Gln Gly Leu Glu Gln Ala Val Asp Asn Phe Glu Gly Lys Lys
Thr Asp 435 440 445Lys Lys Tyr Leu Met Ile Glu Glu Tyr Leu Thr Lys
Glu Leu Leu Ala 450 455 460Leu Asp Ser Val Asp Pro Glu Gly Arg Ala
Asp Val Arg Gln Ala Arg465 470 475 480Arg Asp Gly Val Arg Lys Val
Gln Thr Ile Leu Glu Lys Leu Glu Gln 485 490 495Lys Ala Ile Asp Val
Pro Gly Gln Val Gln Val Tyr Glu Leu Gln Pro 500 505 510Ser Asn Leu
Glu Ala Asp Gln Pro Leu Gln Ala Ile Met Glu Met Gly 515 520 525Ala
Val Ala Ala Asp Lys Gly Lys Lys Asn Ala Gly Asn Ala Glu Asp 530 535
540Pro His Thr Glu Thr Gln Gln Pro Glu Ala Thr Ala Ala Ala Thr
Ser545 550 555 560Asn Pro Ser Ser Met Thr Asp Thr Pro Gly Asn Pro
Ala Ala Pro 565 570 575211966DNAHomo sapiensCDS(43)..(1416)
21cggtgggagc ggggcgggaa gcgcttcagg gcagcggatc cc atg tcg gcc ctg 54
Met Ser Ala Leu 1agg cgc tcg ggc tac ggc ccc agt gac ggt ccg tcc
tac ggc cgc tac 102Arg Arg Ser Gly Tyr Gly Pro Ser Asp Gly Pro Ser
Tyr Gly Arg Tyr5 10 15 20tac ggg cct ggg ggt gga gat gtg ccg gta
cac cca cct cca ccc tta 150Tyr Gly Pro Gly Gly Gly Asp Val Pro Val
His Pro Pro Pro Pro Leu 25 30 35tat cct ctt cgc cct gaa cct ccc cag
cct ccc att tcc tgg cgg gtg 198Tyr Pro Leu Arg Pro Glu Pro Pro Gln
Pro Pro Ile Ser Trp Arg Val 40 45 50cgc ggg ggc ggc ccg gcg gag acc
acc tgg ctg gga gaa ggc gga gga 246Arg Gly Gly Gly Pro Ala Glu Thr
Thr Trp Leu Gly Glu Gly Gly Gly 55 60 65ggc gat ggc tac tat ccc tcg
gga ggc gcc tgg cca gag cct ggt cga 294Gly Asp Gly Tyr Tyr Pro Ser
Gly Gly Ala Trp Pro Glu Pro Gly Arg 70 75 80gcc gga gga agc cac cag
gag cag cca cca tat cct agc tac aat tct 342Ala Gly Gly Ser His Gln
Glu Gln Pro Pro Tyr Pro Ser Tyr Asn Ser85 90 95 100aac tat tgg aat
tct act gcg aga tct agg gct cct tac cca agt aca 390Asn Tyr Trp Asn
Ser Thr Ala Arg Ser Arg Ala Pro Tyr Pro Ser Thr 105 110 115tat cct
gta aga cca gaa ttg caa ggc cag agt ttg aat tct tat aca 438Tyr Pro
Val Arg Pro Glu Leu Gln Gly Gln Ser Leu Asn Ser Tyr Thr 120 125
130aat gga gcg tat ggt cca aca tac ccc cca ggc cct ggg gca aat act
486Asn Gly Ala Tyr Gly Pro Thr Tyr Pro Pro Gly Pro Gly Ala Asn Thr
135 140 145gcc tca tac tca ggg gct tat tat gca cct ggt tat act cag
acc agt 534Ala Ser Tyr Ser Gly Ala Tyr Tyr Ala Pro Gly Tyr Thr Gln
Thr Ser 150 155 160tac tcc aca gaa gtt cca agt act tac cgt tca tct
ggc aac agc cca 582Tyr Ser Thr Glu Val Pro Ser Thr Tyr Arg Ser Ser
Gly Asn Ser Pro165 170 175 180act cca gtc tct cgt tgg atc tat ccc
cag cag gac tgt cag act gaa 630Thr Pro Val Ser Arg Trp Ile Tyr Pro
Gln Gln Asp Cys Gln Thr Glu 185 190 195gca ccc cct ctt agg ggg cag
gtt cca gga tat ccg cct tca cag aac 678Ala Pro Pro Leu Arg Gly Gln
Val Pro Gly Tyr Pro Pro Ser Gln Asn 200 205 210cct gga atg acc ctg
ccc cat tat cct tat gga gat ggt aat cgt agt 726Pro Gly Met Thr Leu
Pro His Tyr Pro Tyr Gly Asp Gly Asn Arg Ser 215 220 225gtt cca caa
tca gga ccg act gta cga cca caa gaa gat gcg tgg gct 774Val Pro Gln
Ser Gly Pro Thr Val Arg Pro Gln Glu Asp Ala Trp Ala 230 235 240tct
cct ggt gct tat gga atg ggt ggc cgt tat ccc tgg cct tca tca 822Ser
Pro Gly Ala Tyr Gly Met Gly Gly Arg Tyr Pro Trp Pro Ser Ser245 250
255 260gcg ccc tca gca cca ccc ggc aat ctc tac atg act gaa agt act
tca 870Ala Pro Ser Ala Pro Pro Gly Asn Leu Tyr Met Thr Glu Ser Thr
Ser 265 270 275cca tgg cct agc agt ggc tct ccc cag tca ccc cct tca
ccc cca gtc 918Pro Trp Pro Ser Ser Gly Ser Pro Gln Ser Pro Pro Ser
Pro Pro Val 280 285 290cag cag ccc aag gat tct tca tac ccc tat agc
caa tca gat caa agc 966Gln Gln Pro Lys Asp Ser Ser Tyr Pro Tyr Ser
Gln Ser Asp Gln Ser 295 300 305atg aac cgg cac aac ttt cct tgc agt
gtc cat cag tac gaa tcc tcg 1014Met Asn Arg His Asn Phe Pro Cys Ser
Val His Gln Tyr Glu Ser Ser 310 315 320ggg aca gtg atc aat gaa gat
tca gat ctt ttg gat tcc caa gtc cag 1062Gly Thr Val Ile Asn Glu Asp
Ser Asp Leu Leu Asp Ser Gln Val Gln325 330 335 340tat agt gct gag
cct cag ctg tat ggt aat gcc acc agt gac cat ccc 1110Tyr Ser Ala Glu
Pro Gln Leu Tyr Gly Asn Ala Thr Ser Asp His Pro 345 350 355aac aat
caa gat caa agt agc agt ctt cct gaa gaa tgt gta cct tca 1158Asn Asn
Gln Asp Gln Ser Ser Ser Leu Pro Glu Glu Cys Val Pro Ser 360 365
370gat gaa agt act cct ccg agt att aaa aaa atc ata cat gtg ctg gag
1206Asp Glu Ser Thr Pro Pro Ser Ile Lys Lys Ile Ile His Val Leu Glu
375 380 385aag gtc cag tat ctt gaa caa gaa gta gaa gaa ttt gta gga
aaa aag 1254Lys Val Gln Tyr Leu Glu Gln Glu Val Glu Glu Phe Val Gly
Lys Lys 390 395 400aca gac aaa gca tac tgg ctt ctg gaa gaa atg cta
acc aag gaa ctt 1302Thr Asp Lys Ala Tyr Trp Leu Leu Glu Glu Met Leu
Thr Lys Glu Leu405 410 415 420ttg gaa ctg gat tca gtt gaa act ggg
ggc cag gac tct gta cgg cag 1350Leu Glu Leu Asp Ser Val Glu Thr Gly
Gly Gln Asp Ser Val Arg Gln 425 430 435gcc aga aaa gag gct gtt tgt
aag att cag gcc ata ctg gaa aaa tta 1398Ala Arg Lys Glu Ala Val Cys
Lys Ile Gln Ala Ile Leu Glu Lys Leu 440 445 450gaa aaa aaa gga tta
tga aaggatttag aacaaagtgg aagcctgtta 1446Glu Lys Lys Gly Leu
455ctaacttgac caaagaacac ttgattaggt taattaccct ctttttgaaa
tgcctgttga 1506tgacaagaag caatacattc cagcttttcc tttgatttta
tacttgaaaa actggcaaag 1566gaatggaaga atattttagt catgaagttg
ttttcagttt tcagacgaat gaatgtaata 1626ggaaactatg gagttaccaa
tattgccaag tagactcact ccttaaaaaa tttatggata 1686tctacaagct
gcttattacc agcaggaggg aaacacactt cacacaacag gcttatcaga
1746aacctaccag atgaaactgg atataatttg agacaaacag gatgtgtttt
tttaaacatc 1806tggatatctt gtcacatttt tgtacattgt gactgctttc
aacatatact tcatgtgtaa 1866ttatagctta gactttagcc ttcttggact
tctgttttgt tttgttattt gcagtttaca 1926aatatagtat tattctctaa
aaaaaaaaaa aaaaaaaaaa 196622457PRTHomo sapiens 22Met Ser Ala Leu
Arg Arg Ser Gly Tyr Gly Pro Ser Asp Gly Pro Ser1 5 10 15Tyr Gly Arg
Tyr Tyr Gly Pro Gly Gly Gly Asp Val Pro Val His Pro 20 25 30Pro Pro
Pro Leu Tyr Pro Leu Arg Pro Glu Pro Pro Gln Pro Pro Ile 35 40 45Ser
Trp Arg Val Arg Gly Gly Gly Pro Ala Glu Thr Thr Trp Leu Gly 50 55
60Glu Gly Gly Gly Gly Asp Gly Tyr Tyr Pro Ser Gly Gly Ala Trp Pro65
70 75 80Glu Pro Gly Arg Ala Gly Gly Ser His Gln Glu Gln Pro Pro Tyr
Pro 85 90 95Ser Tyr Asn Ser Asn Tyr Trp Asn Ser Thr Ala Arg Ser Arg
Ala Pro 100 105 110Tyr Pro Ser Thr Tyr Pro Val Arg Pro Glu Leu Gln
Gly Gln Ser Leu 115 120 125Asn Ser Tyr Thr Asn Gly Ala Tyr Gly Pro
Thr Tyr Pro Pro Gly Pro 130 135 140Gly Ala Asn Thr Ala Ser Tyr Ser
Gly Ala Tyr Tyr Ala Pro Gly Tyr145 150 155 160Thr Gln Thr Ser Tyr
Ser Thr Glu Val Pro Ser Thr Tyr Arg Ser Ser 165 170 175Gly Asn Ser
Pro Thr Pro Val Ser Arg Trp Ile Tyr Pro Gln Gln Asp 180 185 190Cys
Gln Thr Glu Ala Pro Pro Leu Arg Gly Gln Val Pro Gly Tyr Pro 195 200
205Pro Ser Gln Asn
Pro Gly Met Thr Leu Pro His Tyr Pro Tyr Gly Asp 210 215 220Gly Asn
Arg Ser Val Pro Gln Ser Gly Pro Thr Val Arg Pro Gln Glu225 230 235
240Asp Ala Trp Ala Ser Pro Gly Ala Tyr Gly Met Gly Gly Arg Tyr Pro
245 250 255Trp Pro Ser Ser Ala Pro Ser Ala Pro Pro Gly Asn Leu Tyr
Met Thr 260 265 270Glu Ser Thr Ser Pro Trp Pro Ser Ser Gly Ser Pro
Gln Ser Pro Pro 275 280 285Ser Pro Pro Val Gln Gln Pro Lys Asp Ser
Ser Tyr Pro Tyr Ser Gln 290 295 300Ser Asp Gln Ser Met Asn Arg His
Asn Phe Pro Cys Ser Val His Gln305 310 315 320Tyr Glu Ser Ser Gly
Thr Val Ile Asn Glu Asp Ser Asp Leu Leu Asp 325 330 335Ser Gln Val
Gln Tyr Ser Ala Glu Pro Gln Leu Tyr Gly Asn Ala Thr 340 345 350Ser
Asp His Pro Asn Asn Gln Asp Gln Ser Ser Ser Leu Pro Glu Glu 355 360
365Cys Val Pro Ser Asp Glu Ser Thr Pro Pro Ser Ile Lys Lys Ile Ile
370 375 380His Val Leu Glu Lys Val Gln Tyr Leu Glu Gln Glu Val Glu
Glu Phe385 390 395 400Val Gly Lys Lys Thr Asp Lys Ala Tyr Trp Leu
Leu Glu Glu Met Leu 405 410 415Thr Lys Glu Leu Leu Glu Leu Asp Ser
Val Glu Thr Gly Gly Gln Asp 420 425 430Ser Val Arg Gln Ala Arg Lys
Glu Ala Val Cys Lys Ile Gln Ala Ile 435 440 445Leu Glu Lys Leu Glu
Lys Lys Gly Leu 450 455234308DNAHomo
sapiensCDS(247)..(1590)misc_feature(1)..(4308)n=a,c,t or g
23cccccccccc cccccccccc ccngaagacg cccggagcgg ctgctgcagc cagtagcggc
60cccttcaccg gctgccccgc tcagacctag tcgggagggg tgcgaggcat gcagctgggg
120gcccagctcc ggtgccgcac cccgtaaagg gctgatcttc cacctcgcca
cctcagccac 180gggacgccaa gaccgcatcc aattcagact tcttttggtg
cttgtgaaac tgaacacaac 240aaaagt atg gat atg gga aac caa cat cct tct
att agt agg ctt cag 288 Met Asp Met Gly Asn Gln His Pro Ser Ile Ser
Arg Leu Gln 1 5 10gaa atc caa aag gaa gta aaa agt gta gaa cag caa
gtt atc ggc ttc 336Glu Ile Gln Lys Glu Val Lys Ser Val Glu Gln Gln
Val Ile Gly Phe15 20 25 30agt ggt ctg tca gat gac aag aat tac aag
aaa ctg gag agg att cta 384Ser Gly Leu Ser Asp Asp Lys Asn Tyr Lys
Lys Leu Glu Arg Ile Leu 35 40 45aca aaa cag ctt ttt gaa ata gac tct
gta gat act gaa gga aaa gga 432Thr Lys Gln Leu Phe Glu Ile Asp Ser
Val Asp Thr Glu Gly Lys Gly 50 55 60gat att cag caa gct agg aag cgg
gca gca cag gag aca gaa cgt ctt 480Asp Ile Gln Gln Ala Arg Lys Arg
Ala Ala Gln Glu Thr Glu Arg Leu 65 70 75ctc aaa gag ttg gag cag aat
gca aac cac cca cac cgg att gaa ata 528Leu Lys Glu Leu Glu Gln Asn
Ala Asn His Pro His Arg Ile Glu Ile 80 85 90cag aac att ttt gag gaa
gcc cag tcc ctc gtg aga gag aaa att gtg 576Gln Asn Ile Phe Glu Glu
Ala Gln Ser Leu Val Arg Glu Lys Ile Val95 100 105 110cca ttt tat
aat gga ggc aac tgc gta act gat gag ttt gaa gaa ggc 624Pro Phe Tyr
Asn Gly Gly Asn Cys Val Thr Asp Glu Phe Glu Glu Gly 115 120 125atc
caa gat atc att ctg agg ctg aca cat gtt aaa act gga gga aaa 672Ile
Gln Asp Ile Ile Leu Arg Leu Thr His Val Lys Thr Gly Gly Lys 130 135
140atc tcc ttg cgg aaa gca agg tat cac act tta acc aaa atc tgt gcg
720Ile Ser Leu Arg Lys Ala Arg Tyr His Thr Leu Thr Lys Ile Cys Ala
145 150 155gtg caa gag ata atc gaa gac tgc atg aaa aag cag cct tcc
ctg ccg 768Val Gln Glu Ile Ile Glu Asp Cys Met Lys Lys Gln Pro Ser
Leu Pro 160 165 170ctt tcc gag gat gca cat cct tcc gtt gcc aaa atc
aac ttc gtg atg 816Leu Ser Glu Asp Ala His Pro Ser Val Ala Lys Ile
Asn Phe Val Met175 180 185 190tgt gag gtg aac aag gcc cga ggg gtc
ctg att gca ctt ctg atg ggt 864Cys Glu Val Asn Lys Ala Arg Gly Val
Leu Ile Ala Leu Leu Met Gly 195 200 205gtg aac aac aat gag acc tgc
agg cac tta tcc tgt gtg ctc tcg ggg 912Val Asn Asn Asn Glu Thr Cys
Arg His Leu Ser Cys Val Leu Ser Gly 210 215 220ctg atc gct gac ctg
gat gct cta gat gtg tgc ggc cgg aca gaa atc 960Leu Ile Ala Asp Leu
Asp Ala Leu Asp Val Cys Gly Arg Thr Glu Ile 225 230 235aga aat tat
cgg agg gag gta gta gaa gat atc aac aaa tta ttg aaa 1008Arg Asn Tyr
Arg Arg Glu Val Val Glu Asp Ile Asn Lys Leu Leu Lys 240 245 250tat
ctg gat ttg gaa gag gaa gca gac aca act aaa gca ttt gac ctg 1056Tyr
Leu Asp Leu Glu Glu Glu Ala Asp Thr Thr Lys Ala Phe Asp Leu255 260
265 270aga cag aat cat tcc att tta aaa ata gaa aag gtc ctc aag aga
atg 1104Arg Gln Asn His Ser Ile Leu Lys Ile Glu Lys Val Leu Lys Arg
Met 275 280 285aga gaa ata aaa aat gaa ctt ctc caa gca caa aac cct
tct gaa ttg 1152Arg Glu Ile Lys Asn Glu Leu Leu Gln Ala Gln Asn Pro
Ser Glu Leu 290 295 300tac ctg agc tcc aaa aca gaa ttg cag ggt tta
att gga cag ttg gat 1200Tyr Leu Ser Ser Lys Thr Glu Leu Gln Gly Leu
Ile Gly Gln Leu Asp 305 310 315gag gta agt ctt gaa aaa aac ccc tgc
atc cgg gaa gcc agg aga aga 1248Glu Val Ser Leu Glu Lys Asn Pro Cys
Ile Arg Glu Ala Arg Arg Arg 320 325 330gca gtg atc gag gtg caa act
ctg atc aca tat att gac ttg aag gag 1296Ala Val Ile Glu Val Gln Thr
Leu Ile Thr Tyr Ile Asp Leu Lys Glu335 340 345 350gcc ctt gag aaa
aga aag ctg ttt gct tgt gag gag cac cca tcc cat 1344Ala Leu Glu Lys
Arg Lys Leu Phe Ala Cys Glu Glu His Pro Ser His 355 360 365aaa gcc
gtc tgg aac gtc ctt gga aac ttg tct gag atc cag gga gaa 1392Lys Ala
Val Trp Asn Val Leu Gly Asn Leu Ser Glu Ile Gln Gly Glu 370 375
380gtt ctt tca ttt gat gga aat cga acc gat aag aac tac atc cgg ctg
1440Val Leu Ser Phe Asp Gly Asn Arg Thr Asp Lys Asn Tyr Ile Arg Leu
385 390 395gaa gag ctg ctc acc aag cag ctg cta gcc ctg gat gct gtt
gat ccg 1488Glu Glu Leu Leu Thr Lys Gln Leu Leu Ala Leu Asp Ala Val
Asp Pro 400 405 410cag gga gaa gag aag tgt aag gct gcc agg aaa caa
gct gtg agg ctt 1536Gln Gly Glu Glu Lys Cys Lys Ala Ala Arg Lys Gln
Ala Val Arg Leu415 420 425 430gcg cag aat att ctc agc tat ctc gac
ctg aaa tct gat gaa tgg gag 1584Ala Gln Asn Ile Leu Ser Tyr Leu Asp
Leu Lys Ser Asp Glu Trp Glu 435 440 445tac tga aataccagag
atctcacttt tgatactgtt ttgcacttca tatgtgcttc 1640Tyrtatgtataga
gagctttcag ttcattgatt tatacgtgca tatttcagtc tcagtattta
1700tgattgaagc aaattctatt cagtatctgc tgcttttgat gttgcaagac
aaatatcatt 1760acagcacgtt aacttttcca ttcggatcat tatctgtatg
atgtggtgtg gtttgtttgg 1820tttgtccttt tttttgcgtt tttaatcaga
aaacaaaata gaggcagctt ttgtagattt 1880taaatgggtt gtgcaagcat
taaaatgcag gtctttcaga atctagaact aggcataacc 1940ttacataata
ctaggaaaat tatgagaaag gggaaatttt tggttaaata agagtaaggt
2000tcaaacacaa gcagtacatg ttctgtttca ttatgctcga tagaaggctt
ttttttcact 2060tataaggcct gattggtcct acccagctta acggggtggg
gtttttttgt ttgttcagac 2120agtctgttct tttgtaaaca tttttagttg
gaaaaacagc atctgcattt tccccatcct 2180ctacgtttta gagaggaatc
ttgtttttgt gtgcaacata agaaaattat gaaaactaat 2240agccaaaaaa
cctttgagat tgcattaaag agaagggata aaggaccagc aataatacct
2300tgtaagttgc ttttgtttgt aaaatctgag cttatagttt tccttagtga
gtaaattcat 2360aaggatggga acatttaaat taagttaatg ggcctttaaa
aaaaaaaaag gaaacactca 2420tacctgtagt tggaggatga atactggaga
cgggttacca atgtcaggtt atactaaaac 2480taaatcagaa agtctgaatg
tagcacataa tggttctctt ctgttgtcca aggctgtaaa 2540atggacagcc
ttgtcacacc tccccggtgc tgttttacaa cgtgagggta gacgctgtca
2600gtaacccaga gggaccaggc cttcctaggt tttctaggca gtcagctgtt
aaccactcac 2660ttagtaaatg tcataactac acctgctcca ggaccaatca
gtgaaacctg ctcggaatta 2720aaggcttcct ctgggtgcct gctgaacaac
tgagctcatg tcatgggcat gtggtggttt 2780ctctgttgcc tgaaagagcc
attaaagtca gtcgtgcgtg aagcatctct cttctaaagg 2840atgtgtattt
ccataaatgc tttctgagga tccggtacaa aatgatttcc caaagttctg
2900aagtgccttg agaacatgtg ggtccgagtg ttataacaga ctcctccccc
gggtcacctt 2960ttgcctggtc atcctgttag agtacatctt tggaaatcca
gggtaatatt ctctttcaga 3020gatgctcatt gtgtaactct gtgtagggag
atagtcactt taaacagctc aaagtagcta 3080gctaaaggag tagccttaaa
tacctaaaag atgacagaag catagccctt aacaaatctt 3140cagcttgtct
ctcagtattt cccaatcatg aaaatccctt gctatgtctt tcctactaga
3200aatgttctag aatcgctgga cggtggggtc agagggcagt cggtatttag
gccgtgagct 3260tcccatacta ctgcaggtcc aactcctggc aaccgcgggc
tcaaggcagg tcattggaat 3320ccacgttttg gccacagtag ttgtaggatt
gcttttctgt atcataattt tagaatgctc 3380ttaaaatctt gaggaagagt
ttttattttt tatttatttt tgagatggag tctctgttgc 3440ccaggctgca
gtgcagtggt gccatctcag ctcactgcaa cctccacctc ccaggttcaa
3500gcgattctcc tgcctcagcc acctgagtag ctgggagtac aggcatgtgg
caccatgcct 3560ggctaatttt tgtattttta atagagttga gatttcacca
tgatggtcag gctggtctcg 3620aactcctgac ctcgtgatcc gcccgcctcg
gccccccaaa gtgctgggat taacgggtgt 3680gagccacggc gcccagccca
ggaagagttt ttaaattaga gctctgttta attataccac 3740tgggaaatca
tggttacgct tcaggcatat tcttccccag agtactactt acattttaaa
3800tttcattttg taaagttaaa tgtcagcatt ccctttaaaa gtgtccattg
ttctttgaaa 3860gtagacgttt cagtcattct tttcaaacaa gtgtttgtgt
accttttgcc aagctgtggg 3920catcgtgtgt gagtacaggg tgctcagctc
ttccaccgtc attttgaatt gttcacatgg 3980gtaattggtc atggaaatga
tcagattgac cttgattgac tgtcaggcat ggctttgttt 4040ctagtttcaa
tctgttctcg ttccttgtac cggattattc tactcctgca atgaaccctg
4100ttgacaccgg atttagctct tgtcggcctt cgtggggagc tgtttgtgtt
aatatgagct 4160actgcatgta attcttaaac tgggcttgtc acattgtatt
gtatttttgt gatctgtaat 4220gaaaagaatc tgtactgcaa gtaaaaccta
ctccccaaaa atgtgtggct ttgggtctgc 4280attaaacgct gtagtccatg ttcatgcc
430824447PRTHomo sapiens 24Met Asp Met Gly Asn Gln His Pro Ser Ile
Ser Arg Leu Gln Glu Ile1 5 10 15Gln Lys Glu Val Lys Ser Val Glu Gln
Gln Val Ile Gly Phe Ser Gly 20 25 30Leu Ser Asp Asp Lys Asn Tyr Lys
Lys Leu Glu Arg Ile Leu Thr Lys 35 40 45Gln Leu Phe Glu Ile Asp Ser
Val Asp Thr Glu Gly Lys Gly Asp Ile 50 55 60Gln Gln Ala Arg Lys Arg
Ala Ala Gln Glu Thr Glu Arg Leu Leu Lys65 70 75 80Glu Leu Glu Gln
Asn Ala Asn His Pro His Arg Ile Glu Ile Gln Asn 85 90 95Ile Phe Glu
Glu Ala Gln Ser Leu Val Arg Glu Lys Ile Val Pro Phe 100 105 110Tyr
Asn Gly Gly Asn Cys Val Thr Asp Glu Phe Glu Glu Gly Ile Gln 115 120
125Asp Ile Ile Leu Arg Leu Thr His Val Lys Thr Gly Gly Lys Ile Ser
130 135 140Leu Arg Lys Ala Arg Tyr His Thr Leu Thr Lys Ile Cys Ala
Val Gln145 150 155 160Glu Ile Ile Glu Asp Cys Met Lys Lys Gln Pro
Ser Leu Pro Leu Ser 165 170 175Glu Asp Ala His Pro Ser Val Ala Lys
Ile Asn Phe Val Met Cys Glu 180 185 190Val Asn Lys Ala Arg Gly Val
Leu Ile Ala Leu Leu Met Gly Val Asn 195 200 205Asn Asn Glu Thr Cys
Arg His Leu Ser Cys Val Leu Ser Gly Leu Ile 210 215 220Ala Asp Leu
Asp Ala Leu Asp Val Cys Gly Arg Thr Glu Ile Arg Asn225 230 235
240Tyr Arg Arg Glu Val Val Glu Asp Ile Asn Lys Leu Leu Lys Tyr Leu
245 250 255Asp Leu Glu Glu Glu Ala Asp Thr Thr Lys Ala Phe Asp Leu
Arg Gln 260 265 270Asn His Ser Ile Leu Lys Ile Glu Lys Val Leu Lys
Arg Met Arg Glu 275 280 285Ile Lys Asn Glu Leu Leu Gln Ala Gln Asn
Pro Ser Glu Leu Tyr Leu 290 295 300Ser Ser Lys Thr Glu Leu Gln Gly
Leu Ile Gly Gln Leu Asp Glu Val305 310 315 320Ser Leu Glu Lys Asn
Pro Cys Ile Arg Glu Ala Arg Arg Arg Ala Val 325 330 335Ile Glu Val
Gln Thr Leu Ile Thr Tyr Ile Asp Leu Lys Glu Ala Leu 340 345 350Glu
Lys Arg Lys Leu Phe Ala Cys Glu Glu His Pro Ser His Lys Ala 355 360
365Val Trp Asn Val Leu Gly Asn Leu Ser Glu Ile Gln Gly Glu Val Leu
370 375 380Ser Phe Asp Gly Asn Arg Thr Asp Lys Asn Tyr Ile Arg Leu
Glu Glu385 390 395 400Leu Leu Thr Lys Gln Leu Leu Ala Leu Asp Ala
Val Asp Pro Gln Gly 405 410 415Glu Glu Lys Cys Lys Ala Ala Arg Lys
Gln Ala Val Arg Leu Ala Gln 420 425 430Asn Ile Leu Ser Tyr Leu Asp
Leu Lys Ser Asp Glu Trp Glu Tyr 435 440 445
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