U.S. patent application number 13/165890 was filed with the patent office on 2011-10-13 for device for monitoring blood flow to brain.
This patent application is currently assigned to Orsan Medical Technologies Ltd.. Invention is credited to Shlomi BEN-ARI, Alon Rappaport, Aharon Shapira.
Application Number | 20110251503 13/165890 |
Document ID | / |
Family ID | 34972097 |
Filed Date | 2011-10-13 |
United States Patent
Application |
20110251503 |
Kind Code |
A1 |
BEN-ARI; Shlomi ; et
al. |
October 13, 2011 |
DEVICE FOR MONITORING BLOOD FLOW TO BRAIN
Abstract
A method of estimating blood flow in the brain, comprising: a)
causing currents to flow inside the head by producing electric
fields inside the head; b) measuring at least changes in the
electric fields and the currents; and c) estimating changes in the
blood volume of the head, using the measurements of the electric
fields and the currents.
Inventors: |
BEN-ARI; Shlomi; (Binyamina,
IL) ; Rappaport; Alon; (Tel-Aviv, IL) ;
Shapira; Aharon; (Jerusalem, IL) |
Assignee: |
Orsan Medical Technologies
Ltd.
Natania
IL
|
Family ID: |
34972097 |
Appl. No.: |
13/165890 |
Filed: |
June 22, 2011 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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10893570 |
Jul 15, 2004 |
7998080 |
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13165890 |
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PCT/IL03/00042 |
Jan 15, 2003 |
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10893570 |
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60348278 |
Jan 15, 2002 |
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Current U.S.
Class: |
600/504 |
Current CPC
Class: |
A61B 5/0265 20130101;
A61B 5/0535 20130101; A61B 5/0295 20130101; A61B 5/0261 20130101;
A61B 5/245 20210101; A61B 2562/164 20130101; A61B 5/6814 20130101;
A61B 5/6817 20130101 |
Class at
Publication: |
600/504 |
International
Class: |
A61B 5/026 20060101
A61B005/026 |
Claims
1. A method of estimating perfusion in the brain comprising: a)
causing currents to flow inside the head by producing an electric
field inside the head, using two current-carrying electrodes each
attached to the head close to a temporal artery, and applying two
different electric potentials to the current-carrying electrodes,
keeping the current constant; b) measuring relative changes in the
electric field at the constant current; c) estimating relative
changes in the blood volume of the head, using the measurements of
the relative changes in the electric field at the constant current;
and d) estimating perfusion in the brain, from the relative changes
in blood volume of the head.
2. An apparatus for estimating blood flow to the brain, comprising:
a) a power supply; b) an electric field source, comprising at least
two current-carrying electrodes, adapted for forming a good
electrical connection to the head, and connected to the power
supply, which uses the power supply to produce an electric field in
the head, at a safe amplitude and frequency, thereby producing a
current in the head; c) an electrical element which determines at
least changes in the electric field in the head, using two voltage
measuring electrodes adapted for forming a good electrical
connection to the head, and at least changes in the current in the
head, having sufficient precision to at least estimate changes in
the impedance of the head; and d) a monitor which displays at least
information telling a user when changes in the impedance of the
head show a significant change in blood flow rate; wherein at least
one of the electrodes is adapted by its size and shape to be placed
on a surface of the head near an opening of the skull, in such a
manner that it conforms to the curvature of the head.
3. An apparatus according to claim 2, wherein the electrical
element comprises: a) a controller in the power supply which
controls one of the output voltage and the output current of the
power supply, or a combination of the output voltage and output
current; and b) a meter which measures one of voltage across the
head, current through the head, or a combination of voltage across
the head and current through the head which is not controlled by
the controller.
4. An apparatus according to claim 3, wherein the controller in the
power supply controls the output current, and the meter is a
voltmeter, connected to the voltage-measuring electrodes.
5. An apparatus according to claim 4, wherein the current-carrying
electrodes comprise at least three current-carrying electrodes, and
at least two of the current-carrying electrodes are connected in
parallel to the same voltage.
6. An apparatus according to claim 2, and including at least one
electrode structure to which at least one current-carrying
electrode and at least one voltage-measuring electrode are
mechanically connected.
7. An apparatus according to claim 2, wherein the voltage-measuring
electrodes are adapted to be placed inside an opening in the
head.
8. An apparatus according to claim 7, wherein the voltage-measuring
electrodes are adapted to be placed inside the ears.
9. An apparatus according to claim 8, wherein the voltage-measuring
electrodes are conical and padded, thereby allowing them to be
pressed firmly enough into the ears to make good electrical
contact, without damaging the ear drums.
10. An apparatus according to claim 8, and including a probe
adapted for measuring blood flow photoplethysmographically in the
ears, which probe is combined with the voltage-measuring
electrodes.
11. An apparatus according to claim 2, wherein the opening is an
eye socket, and the electrode is shaped to fit over a closed
eyelid.
12. An apparatus according to claim 2, wherein the opening is the
foramen magnum, and the electrode is shaped to fit near the base of
the skull.
13. An apparatus according to claim 2, wherein the opening is an
ear, and the electrode is sized and shaped to be placed in the ear
canal.
14. An apparatus according to claim 2, wherein the opening is an
ear, and the electrode is sized and shaped to be placed behind the
ear.
15. An apparatus according to claim 2, wherein the at least two
current-carrying electrodes comprise at least three
current-carrying electrodes, and the power supply is capable of
simultaneously applying at least three different voltages to the
current-carrying electrodes, whereby a desired current distribution
is produced inside the head.
16. An apparatus according to claim 15, wherein the
current-carrying electrodes are adapted to be placed in locations
on the head such that the desired current distribution is
concentrated in a desired region of the brain.
17. An apparatus according to claim 2, and including a
photoplethysmographic blood-flow measuring probe, sized and shaped
to be placed in the ears.
18. An apparatus according to claim 17, where the probe is
sufficiently wide at its base that it cannot damage the eardrum
when inserted into the ears.
19. An apparatus according to claim 17, wherein the probe is
surrounded by a holding element which, when inserted into the ear,
holds the probe in a position and orientation to allow repeated
optical measurements of the same location.
20. An apparatus according to claim 2, which is portable enough for
use in the field by emergency medical technicians.
21. An apparatus according to claim 2, and including: a) a head
motion sensor; and b) a controller which uses data from the head
motion sensor to reduce motion artifacts in estimating the blood
flow.
22. An apparatus for estimating blood flow to the brain,
comprising: a) a power supply; b) an electric field source,
comprising at least two current-carrying electrodes, adapted for
forming a good electrical connection to the head, and connected to
the power supply, which uses the power supply to produce an
electric field in the head, at a safe amplitude and frequency,
thereby producing a current in the head; c) an electrical element
which determines at least changes in the electric field in the
head, using two voltage measuring electrodes adapted for forming a
good electrical connection to the head, and at least changes in the
current in the head, having sufficient precision to at least
estimate changes in the impedance of the head; and d) a monitor
which displays at least information telling a user when changes in
the impedance of the head show a significant change in blood flow
rate; wherein at least a portion of one current-carrying electrode
is adjacent on two opposite sides to two portions of a same
voltage-measuring electrode, or at least a portion of one
voltage-measuring electrode is adjacent on two opposite sides to
two portions of a same current-carrying electrode, or both.
23. An apparatus according to claim 22, wherein at least one of
said electrodes comprises an annular-shaped electrode that
surrounds the electrode or the portion of the electrode that said
annular-shaped electrode is adjacent to.
24. An apparatus according to claim 22, wherein at least portions
of the voltage-measuring electrode and the current-carrying
electrode form intertwined spirals.
25. A method of estimating changes in blood volume of the head,
comprising: a) causing currents to flow inside the head by
producing electric fields inside the head, by placing at least two
current-carrying electrodes on the head, and applying at least two
different electric potentials to the current-carrying electrodes;
b) measuring at least changes in the electric fields using at least
two voltage-measuring electrodes placed on the head, and at least
changes in the currents; and c) estimating changes in the blood
volume of the head, using the measurements of the electric fields
and the currents; wherein at least one of the electrodes is placed
on or near an opening in the skull, when causing the currents to
flow and when measuring at least the changes in electric fields and
currents.
26. A method according to claim 25, wherein at least one electrode
placed on or near an opening of the skull is placed in an ear
canal, or behind an ear.
27. A method according to claim 25, wherein at least one electrode
placed on or near an opening of the skull is placed on a closed
eyelid.
28. A method according to claim 25, wherein at least one electrode
placed on or near an opening of the skull is placed near a foramen
magnum.
Description
RELATED APPLICATIONS
[0001] The present application is a continuation of U.S. patent
application Ser. No. 10/893,570 filed on Jul. 15, 2004, which is a
continuation-in-part of PCT Patent Application No. PCT/IL03/00042
having International filing date of Jan. 15, 2003, which claims the
benefit of priority of U.S. Provisional Patent Application No.
60/348,278 filed on Jan. 15, 2002. The contents of the above
applications are all incorporated herein by reference.
FIELD OF THE INVENTION
[0002] The field of the invention is medical instrumentation, for
example for measuring blood flow to the brain.
BACKGROUND OF INVENTION
[0003] There is a need to measure cerebral blood flow during
several medical events and procedures, because any disturbance to
the flow of blood to the brain may cause an injury to the function
of the brain cells, and even death of brain cells if the
disturbance is prolonged. Maintaining blood flow to the brain is
especially important because brain cells are more vulnerable to a
lack of oxygen than other cells, and because brain cells usually
cannot regenerate following an injury. A number of common
situations may cause a decrease in the general blood flow to the
brain, including arrhythmia, myocardial infarction, and traumatic
hemorrhagic shock. In such cases, data regarding the quantity of
blood flow in the brain, and the changes in flow rate, may be
vastly important in evaluating the risk of injury to the brain
tissue and the efficacy of treatment. The availability of such data
may enable the timely performance of various medical procedures to
increase the cerebral blood flow, and prevent permanent damage to
the brain.
[0004] Existing means for measuring cerebral blood flow are
complex, expensive, and in some cases invasive, which limits their
usefulness. Three non-portable methods that are presently used only
in research are: 1) injecting radioactive xenon into the cervical
carotid arteries and observing the radiation it emits as it spreads
throughout the brain; 2) positron emission tomography, also based
on the injection of radioactive material; and 3) magnetic resonance
angiography, performed using a room-sized, expensive, magnetic
resonance imaging system, and requiring several minutes to give
results. A fourth method, trans-cranial Doppler (TCD) uses
ultrasound and is not invasive, and gives immediate results.
However, TCD fails in about 15% of patients, due to the difficulty
of passing sound waves through the cranium, and it requires great
skill by professionals who have undergone prolonged training and
practice in performing the test and deciphering the results.
Another disadvantage of TCD is that it measures only regional blood
flow in the brain, and does not measure global blood flow.
[0005] Impedance measurements of the thorax are a known technique
for monitoring intracellular and extracellular fluid in the lungs,
in patients with congestive heart failure. This technique is
effective because the resistive impedance of the thorax at low
frequency depends on the volume of blood and other electrolytic
fluids, which have a relatively high electrical conductivity,
present outside cells. (The capacitive impedance of the thorax, on
the other hand, depends largely on the volume of fluid inside
cells.) A complicating effect in measuring the impedance of the
thorax is the changing volume of air in the lungs during the
breathing cycle, since air has a very high resistivity, and various
methods have been developed to compensate for this effect. See, for
example, U.S. Pat. Nos. 5,788,643, 5,749,369, and 5,746,214, the
disclosures of which are incorporated herein by reference.
[0006] In these impedance measurements, current is often passed
through the thorax with one set of electrodes, and a different set
of electrodes is used to make voltage measurements. This "four
wire" method essentially eliminates the voltage drop associated
with the current flowing through any impedance in series with the
thorax in the current-carrying circuit, for example due to poor
contact (possibly changing unpredictably) between the
current-carrying electrodes and the skin, or in the power supply
producing the current. Those voltage drops, which are not of
interest in measuring the impedance of the thorax, do not occur in
the separate voltage-measuring circuit because it has high
impedance and very little current flowing in it.
[0007] Photoplesthysmography is another technique used to monitor
blood flow and blood volume, using the reflectivity of red or
infrared light from the surface of the skin, for example the
finger, or the earlobe. See, for example, J. Webster, "Measurement
of Flow and Volume of Blood," in John G. Webster (ed.), Medical
Instrumentation: Application and Design (Wiley, 1997).
[0008] Magnetically inducing electrical fields in the body,
including the head, is used in some existing medical procedures,
principally for stimulation of the peripheral or central nervous
system. See, for example, PCT publication WO 96/16692, the
disclosure of which is incorporated herein by reference. Peripheral
nerve stimulation is also a well known unwanted side effect of the
time-varying magnetic fields used in magnetic resonance
imaging.
SUMMARY OF THE INVENTION
[0009] An aspect of some embodiments of the invention relates to
using impedance measurements of at least part of the head to
estimate blood flow to the brain. For some applications, it is not
necessary to measure the absolute impedance accurately, since the
blood flow is estimated, and/or the presence of significant blood
flow is ascertained, by observing changes in the impedance (due to
changes in blood volume) during a cardiac cycle. For some
applications, even the absolute blood flow rate need not be
measured accurately, but it is enough to detect changes in the
blood flow rate over time. Various methods are used to make the
impedance measurements more sensitive to the impedance of the
brain, and less sensitive to the much greater impedance of the
skull, as well as to reduce motion artifacts.
[0010] In some embodiments of the invention, the impedance of the
head is measured by passing current through the head and measuring
the associated voltage by electrodes. To reduce the errors in
measurement that are associated with the high relative impedance of
the skull, current is passed through the head using one or more
pairs of current-carrying electrodes, and a separate pair of
voltage-measuring electrodes, on a separate high impedance circuit,
is used to measure the voltage across the head. Optionally,
sensitivity to the skull impedance is further reduced by inserting
the voltage measuring electrodes into the ears. Alternatively or
additionally, the nose or other orifices, or thin bone areas in the
skull, are used. Examples of orifices are openings in the skull,
for example the eye sockets, or the foramen magnum. An example of a
thin bone area is the temple.
[0011] Optionally, electrodes of large area are used, or one or
more electrodes are spread out over a large area (for example, by
using an annular electrode) even if the total area of the
electrodes themselves is not so large, in order to focus the
current to go through the interior of the head, and not so much
through the scalp. Optionally, a large voltage sensing area, for
example a plurality of voltage-measuring electrodes spread out over
a large area and shorted together, or a single voltage-measuring
electrode with a long, winding shape or with many arms spread out
over a large area, is interspersed among a current-carrying
electrode or electrodes similarly spread out over a large area.
Optionally, when the distance between the different electrodes, or
the different arms of the electrodes, is comparable to or greater
than the thickness of the scalp and skull, or even just the
thickness of the scalp, then the voltage measured by
voltage-measuring electrode will tend to be relatively insensitive
to the voltage drop across the scalp and skull, and will be
relatively more sensitive to the voltage drop across the brain. For
example, the individual electrodes, or the arms of the electrodes,
are at least 1 mm wide, or at least 2 mm wide, or at least 5 mm
wide, or at least 1 cm wide, and the electrodes are separated by
similar distances. The total spread of the electrodes on each side
of the head, for example, is at least 1 cm, or at least 2 cm, or at
least 5 cm.
[0012] Optionally, the impedance of the head is measured over time.
The change in impedance over a pulse cycle, for example, is a
measure of the change in blood volume during a pulse cycle, and
hence the blood flow rate. Even if there are inaccuracies in the
blood flow rate measured in this way, the technique is adequate for
detecting a substantial drop in blood flow to the brain that occurs
during surgery, or in determining whether CPR is being performed
effectively.
[0013] In some embodiments of the invention inductive measurements
are used to estimate the impedance of the head, and hence the blood
volume and rate of blood flow to the brain. One or more coils with
alternating current flowing in them, adjacent to the head, are used
to produce a changing magnetic field inside the head, and hence to
induce an electric field, which drives eddy currents in the brain.
The magnitude of these eddy currents depends on the impedance of
the brain, and hence on the blood volume of the brain. The eddy
currents in the brain are measured by the changing magnetic field,
and hence voltage, which they induce in the driving coils, or in
one or more separate measuring coils, which are place around the
head, approximately parallel to the driving coils.
[0014] Optionally, instead of or in addition to using the driving
coils or measuring coils to measure the eddy currents in the brain,
voltage-measuring electrodes on the skin are used to measure the
induced electric field. Alternatively or additionally, magnetic
field sensors, for example Hall sensors, flux gate magnetometers,
or SQUIDS, are used to measure the magnetic field. Both the induced
electric field and the magnetic field depend on the impedance of
the brain, because the eddy currents in the brain affect the
magnetic field.
[0015] An aspect of some embodiments of the invention concerns the
use of photoplethysmography to estimate the rate of blood flow to
the brain, either alone or in conjunction with impedance
measurements. Optionally, photoplethysmography is performed inside
the ear, which makes it more sensitive to the important internal
blood flow in the head, as opposed to measurements in the earlobe
which depend on peripheral blood flow. A probe for
photoplethysmography inside the ear is optionally combined with a
voltage-measuring probe used inside the ear for impedance
measurements.
[0016] There is thus provided, in accordance with an embodiment of
the invention, a method of estimating blood flow in the brain,
comprising: [0017] a) causing currents to flow inside the head by
producing electric fields inside the head; [0018] b) measuring at
least changes in the electric fields and the currents; and [0019]
c) estimating changes in the blood volume of the head, using the
measurements of the electric fields and the currents.
[0020] In an embodiment of the invention, using the measurements of
electric fields and the currents comprises calculating the
impedance of the head at least two different times.
[0021] In an embodiment of the invention, producing electric fields
inside the head comprises placing at least two current-carrying
electrodes on the head and applying at least two different voltages
to the current-carrying electrodes.
[0022] Optionally, there is more than one current-carrying
electrode at the same voltage.
[0023] Optionally, the current-carrying electrodes are sufficiently
large in area so that a significant amount of the current flows
through the interior of the skull, and not through the scalp.
[0024] Alternatively or additionally, the electrodes are spread out
enough in area so that a significant amount of the current flows
through the interior of the skull, and not through the scalp.
[0025] In an embodiment of the invention, measuring the electric
fields comprises placing at least two voltage-measuring electrodes
on the head, on a separate circuit from the current-carrying
electrodes, and measuring the voltage difference between the
voltage-carrying electrodes.
[0026] Optionally, placing the voltage-measuring electrodes on the
head comprises placing them inside the ears.
[0027] Optionally, placing the current-carrying electrodes on the
head comprises placing at least three current-carrying electrodes
on the head, and applying different voltages to the
current-carrying electrodes comprises applying at least three
different voltages to the current-carrying electrodes so that a
desired current distribution is produced in the head.
[0028] Optionally, the desired current distribution is concentrated
in a desired region of the brain, and estimating the blood flow in
the brain comprises estimating the blood flow in the desired region
of the brain.
[0029] In an embodiment of the invention, producing electric fields
inside the head comprises:
[0030] a) placing at least one induction coil adjacent to the head;
and
[0031] b) running time-varying current through said at least one
induction coils; thereby inducing the electric fields inside the
head, whereby causing currents to flow inside the head comprises
causing eddy currents to flow inside the head.
[0032] Optionally, the frequency distribution of the time-varying
current running through the at least one induction coils is such
that the eddy currents flowing in the head do not reduce the
magnetic field at any point in the head by more than a factor of
3.
[0033] In an embodiment of the invention, measuring the currents
inside the head comprises measuring the magnetic field produced by
the eddy currents.
[0034] Optionally, measuring the magnetic field produced by the
eddy currents comprises: [0035] a) placing two voltage-measuring
electrodes on the head; [0036] b) measuring the induced electric
field by measuring the voltage difference between the
voltage-measuring electrodes; and [0037] c) subtracting the part of
the electric field induced by the magnetic field produced by the
currents running in the at least one induction coils, thereby
finding the part of the electric field induced by the magnetic
field produced by the eddy currents.
[0038] In an embodiment of the invention, the method also comprises
using photoplethysmography on tissue inside the head.
[0039] Optionally, the tissue is inside the ear.
[0040] Alternatively or additionally, the tissue is inside the
nose.
[0041] In an embodiment of the invention, the method is used to
monitor the blood flow in a patient's brain during surgery.
[0042] Alternatively, the method is used to monitor the blood flow
in a patient's brain during CPR, to verify that the CPR is being
performed effectively.
[0043] Alternatively, the method is used to monitor the blood flow
in the brain of a patient with a medical condition likely to lead
to loss of blood flow to the brain.
[0044] There is thus also provided, in accordance with an
embodiment of the invention, an apparatus for estimating blood flow
to the brain, comprising: [0045] a) a power supply; [0046] b) an
electric field source which uses the power supply to produce an
electric field in the head, at a safe amplitude and frequency,
thereby producing a current in the head; [0047] c) an electrical
element which determines at least changes in the electric field in
the head and at least changes in the current in the head, having
sufficient precision to at least estimate changes in the impedance
of the head; and [0048] d) a monitor which displays at least
information telling a user when changes in the impedance of the
head show a significant change in blood flow rate.
[0049] In an embodiment of the invention, the electric field source
comprises at least two current-carrying electrodes, adapted for
forming a good electrical connection to the head, and connected to
the power supply, and the electrical element comprises: [0050] a) a
controller in the power supply which controls one of the output
voltage and the output current of the power supply, or a
combination of the output voltage and output current; and [0051] b)
a meter which measures one of voltage across the head, current
through the head, or a combination of voltage across the head and
current through the head which is not controlled by the
controller.
[0052] Optionally, the controller in the power supply controls the
output current, and the meter is a voltmeter, and there are two
voltage-measuring electrodes, connected to the voltmeter, which
voltage-measuring electrodes are adapted for forming a good
electrical connection to the head.
[0053] Optionally, the current-carrying electrodes comprise at
least three current-carrying electrodes, and at least two of the
current-carrying electrodes are connected in parallel to the same
voltage.
[0054] Optionally, the current-carrying electrodes are collectively
sufficiently large in area so that a significant amount of the
current flows through the interior of the skull, and not through
the scalp.
[0055] Alternatively or additionally, the current-carrying
electrodes are collectively sufficiently spread out in area so that
a significant amount of the current flows through the interior of
the skull, and not through the scalp.
[0056] In an embodiment of the invention, the voltage-measuring
electrodes are adapted to be placed inside an opening in the
head.
[0057] Optionally, the voltage-measuring electrodes are adapted to
be placed inside the ears.
[0058] Optionally, the voltage-measuring electrodes are conical and
padded, thereby allowing them to be pressed firmly enough into the
ears to make good electrical contact, without damaging the ear
drums.
[0059] Optionally, there is also a probe adapted for measuring
blood flow photoplethysmographically in the ears, which probe is
combined with the voltage-measuring electrodes.
[0060] In an embodiment of the invention, the at least two
current-carrying electrodes comprise at least three
current-carrying electrodes, and the power supply is capable of
simultaneously applying at least three different voltages to the
current-carrying electrodes, whereby a desired current distribution
is produced inside the head.
[0061] Optionally, the current-carrying electrodes are adapted to
be placed in locations on the head such that the desired current
distribution is concentrated in a desired region of the brain.
[0062] In an embodiment of the invention: [0063] a) the power
supply produces a time-varying power supply current; [0064] b) the
means for producing an electric field in the head comprises at
least one induction coil, connected to the power supply, which
induces an electric field in the head by producing a time-varying
magnetic field in the head, the current in the head thereby being
an eddy current; [0065] c) the means for determining at least
changes in the electric field in the head comprises a controller in
the power supply, which determines the rate of change of the power
supply current, and thereby determines the rate of change of the
magnetic field in the head, and the induced electric field in the
head; and [0066] d) the means for determining at least changes in
the current in the head comprises a sensor which senses the
magnetic field produced by the current in the head.
[0067] Optionally, the power supply is capable of operating over at
least part of the range between 10 kHz and 100 kHz.
[0068] Alternatively or additionally, the power supply is capable
of operating over at least part of the range between 100 kHz and 1
MHz.
[0069] Alternatively or additionally, the power supply is capable
of operating over at least part of the range between 1 MHz and 10
MHz.
[0070] Alternatively or additionally, the power supply is capable
of operating over at least part of the range between 10 MHz and 100
MHz.
[0071] In an embodiment of the invention, the sensor comprises at
least one of the at least one induction coils.
[0072] Alternatively or additionally, the sensor comprises a
separate sensing coil which measures the voltage induced by changes
in magnetic flux passing through it.
[0073] Alternatively or additionally, the sensor comprises a
solid-state magnetic field sensor.
[0074] Alternatively or additionally, the sensor comprises
voltage-measuring electrodes which measure an electric field
induced by the time-varying magnetic field produced by the at least
one induction coil.
[0075] In an embodiment of the invention, there is also a
photoplethysmographic blood-flow measuring probe, sized and shaped
to be placed in the ears.
[0076] Optionally, the probe is sufficiently wide at its base that
it cannot damage the eardrum when inserted into the ears.
[0077] Optionally, the probe is surrounded by a holding element
which, when inserted into the ear, holds the probe in a position
and orientation to allow repeated optical measurements of the same
location.
[0078] In an embodiment of the invention, the apparatus is portable
enough for use in the field by emergency medical technicians.
[0079] In an embodiment of the invention, there is also: [0080] a)
a head motion sensor; and [0081] b) a controller which uses data
from the head motion sensor to reduce motion artifacts in
estimating the blood flow.
BRIEF DESCRIPTION OF THE DRAWINGS
[0082] Exemplary embodiments of the invention are described in the
following sections with reference to the drawings. The drawings are
generally not to scale and the same or similar reference numbers
are used for the same or related features on different
drawings.
[0083] FIG. 1A is a schematic cross-sectional view of a head with
electrodes, according to an exemplary embodiment of the
invention;
[0084] FIGS. 1B, 1C, and 1D are drawings of the surface of an
electrode structure, which surface is to be placed facing the skin,
according to three other exemplary embodiments of the
invention;
[0085] FIG. 2A is a schematic plot of typical impedance data
according to the same or a different exemplary embodiment of the
invention than those shown in FIGS. 1A-1D;
[0086] FIG. 2B is a schematic cross-sectional view showing an
electrode and an optical probe inserted into an ear;
[0087] FIGS. 3A, 3B, and 3C are schematic perspective views of a
head with induction coils according to three other exemplary
embodiments of the invention;
[0088] FIG. 4 is a schematic view of the head showing the brain and
induction coils, according to the same embodiment of the invention
as FIG. 3B; and
[0089] FIGS. 5A, 5B, and 6 are perspective views of a head with
electrodes, and a monitor, according to three different exemplary
embodiments of the invention.
DETAILED DESCRIPTION OF EXEMPLARY EMBODIMENTS
[0090] FIG. 1 shows a cross-section of a head 100 seen from the
top, including a skull 102 with two openings 104 associated with
the ears, and an interior region 106 which includes the brain. It
is desired to measure changes in the electrical impedance of
interior region 106, without having the measurements dominated by
the much greater impedance of the skull. Two positive
current-carrying electrodes 108 are shown in contact with the skin
on the right side of the head, one in front of the ear and one
behind the ear. Similarly, two negative current-carrying electrodes
are shown in contact with the skin on the left side of the head.
This may be varied, for example there is only one electrode on each
side, or there are more than two electrodes on each side, or the
electrodes are above or below the ears, or on the ears, and the
number of positive electrodes need not equal the number of negative
electrodes. Having a large area of the cranium, for example 2% or
5% or 10% or more of the surface of the head, covered by
electrodes, keeps a significant amount of the current flowing
through the interior of the head, and reduces the amount of current
that bypasses the interior of the head by flowing through the
scalp. This is facilitated by having more than one electrode on
each side, or by having large electrodes, which conform or can be
made to conform to the curvature of the head. Optionally, instead
of having one large electrode on each side of the head, or several
small electrodes at the same voltage on each side covering a large
total area, there is, on at least one side of the head, an annular
electrode with a wide diameter, even if it has a thin annulus with
a small total area. Optionally, there is also an electrode, not
necessarily large, in the center of the annular electrode, with the
same voltage, and optionally the annulus has one or more breaks in
it. Alternatively or additionally, there are a plurality of
electrodes spread out over a large area, with the same voltage,
even if the total area of the electrodes themselves is small. The
current will tend to be focused to go through the interior of the
head, rather than through the scalp, as if the whole area inside
the annular electrode, or the whole area covered by the spread out
distribution of electrodes, were one large electrode. All of these
options can be used on either one or both sides of the head.
[0091] Optionally, the electrode configuration causes at least 90%
of the current to go through the interior of the head.
Alternatively, at least 50% of the current goes through the
interior of the head, or at least 20%, or at least 10%, or at least
1%. Having a significant amount of current going through the
interior of the head means having enough current going through the
interior of the head so that the impedance measurements are
sufficiently dependent on blood volume that they can be used to
measure the blood flow.
[0092] Optionally, electrodes 108 and 110 are kept in good
electrical contact with the skin by a conductive gel, such as those
used in ECG measurements.
[0093] A constant current is driven from electrodes 108 to
electrodes 110 by power supply 112. Alternatively power supply 112
produces a constant voltage, or some combination of constant
voltage and constant current, but the current is measured.
Optionally, different electrodes, even on the same side of the
head, have different voltages applied to them by the power supply,
in order to produce a desired distribution of current flowing
through the head. For example, current could be concentrated in one
region of the brain, to measure blood flow in that region, or
current could be distributed uniformly to measure global blood
flow. Optionally, the current density is more than twice as great
in one region of the brain than it is in other regions.
Alternatively, the current density is 50% greater, or 20% greater,
or 10% greater, in one region of the brain than in other regions.
The current distribution in the brain produced by different shapes,
sizes, locations and voltages of electrodes are optionally
evaluated using finite element analysis software, or any other
numerical or analytic method known to the art.
[0094] Although the foregoing description, and the arrow shown in
power supply 112, suggest that DC current is applied to the head,
in practice, for safety reasons, AC current is generally applied,
optionally at frequencies between 20 and 100 kHz, and the
"positive" and "negative" electrodes 108 and 110 in FIG. 1 really
represent two different phases of the AC voltage applied by the
power supply, 180 degrees apart. Optionally, there are three or
more electrodes to which three or more different phases of AC
voltage are applied. For safety reasons, and to avoid nerve
stimulation, the current is optionally limited, for example to 0.5
milliamperes or 1 milliampere, depending to some extent on the area
and location of the electrodes. This is a potential advantage of
using a constant current rather than a constant voltage power
supply. Optionally, the current is not too much lower than this,
for example not less than 0.1 milliampere, since the impedance
measurement may be less accurate at lower current. Optionally, the
current is applied at frequencies between 20 and 40 kHz, which is
high enough to run the maximum current safely, but is still low
enough so that the current is largely confined to the blood and
other extracellular fluid, and is excluded from the interiors of
cells by the high resistance cell membranes. This makes the
measured impedance maximally sensitive to blood volume.
[0095] Optionally, the current is run between 70 and 100 kHz,
instead of or in addition to 20 to 40 kHz. In the higher frequency
range, the cell membranes may already begin to short out due to
their finite capacitance, and a significant amount of the current
may flow inside the cells, as well as in the blood and
extracellular fluid. Although the impedance may be somewhat less
sensitive to changes in blood volume in the higher frequency range,
the spatial distribution of current may be different than at lower
frequency, due to the inhomogeneous distribution of blood and
extracellular fluid throughout the brain. Obtaining impedance data
at high frequency, especially if it supplements data obtained at
lower frequency, may provide additional data about the distribution
of blood flow in the brain, or the distribution of pooled blood
from a cerebral hemorrhage, for example. Optionally, the current is
also run at intermediate frequencies, 40 to 70 kHz, to provide
additional data on blood distribution, or is only run at
intermediate frequencies.
[0096] In an exemplary embodiment, voltage-measuring electrodes 114
are inserted into the ears through openings 104, reaching locations
that are relatively well connected electrically with the interior
of the skull, and measure the voltage across the interior of the
head associated with the current flowing between current-carrying
electrodes 108 and 110. Optionally, electrodes 114 are conical
Ag/AgCl electrodes padded with a sponge soaked in a conductive gel.
The conical shape prevents the electrodes from pressing against and
possibly damaging the ear drums, when they are pushed with some
force into the ear canals in order to make good electrical contact.
Alternatively, electrodes 114 are shaped like the ear canal,
similar to hearing aids, or are soft enough so that they conform to
the shape of the ear canal, but making the electrodes relatively
rigid has the potential advantage that they may stay in contact
with the skin better. Optionally, the ear canal between electrodes
114 and the ear drum is completely or partially filled with a
conductive gel, or another conducting fluid-like material.
Optionally, there are also voltage-measuring electrodes placed just
behind the ear, which are shorted to the voltage-measuring
electrodes placed in the ear canal, to provide a greater total
electrode area, and to spread out the electrode area more.
Electrodes 114 are attached to a high impedance recording device
116, so very little current flows through electrodes 114. This
means that the voltage measured by recording device 116 depends
mostly on the voltage drop across the interior of the head produced
by power supply 112, and does not depend very much on the impedance
of the skull, or on the impedance associated with the contact
between electrodes 114 and the head, or between electrodes 108 or
110 and the head. If the voltage were instead measured between
electrodes 108 and 110, then the voltage might be dominated by the
skull, or by the contact between the electrodes and the skin.
Alternatively, electrodes 114 are not placed inside the ears, but
on the surface of the head. Even in this case, depending on the
dimensions and placement of electrodes 108, 110 and 114, and on the
thickness of the skull, the voltage measured by recording device
116 is not sensitive to the voltage drop across the skull, or at
least is less sensitive to the voltage drop across the skull than
if the voltage were measured between electrodes 108 and 110, and
the voltage measured by recording device 116 is sufficiently
sensitive to the impedance of the interior of the head that changes
in blood volume can be detected. In particular, if the diameter of
the current-carrying electrodes, and the distance from the
current-carrying electrodes to the voltage-measuring electrodes, is
at least a few times greater than the thickness of the skull, then
the potential of the voltage-measuring electrodes will tend to be
substantially closer to the potential of the brain surface than to
the potential of the current-carrying electrodes, on that side of
the head. In some embodiments, electrodes 114 are placed on the
temples, where the skull is thinner than at most other parts of the
head, in order to make the voltage measured by recording device 116
less dependent on the skull impedance, and more sensitive to the
impedance of the interior of the head. In other exemplary
embodiments, voltage-measuring electrodes 114, or current-carrying
electrodes 108 and 110, or both, are placed on the temples, or over
the eye sockets, for example over the eyelids when the eyes are
closed, or at the base of the skull near the foramen magnum, or
over any combination of these locations.
[0097] In an exemplary embodiment of the invention, as shown in
FIG. 1B, the current-carrying electrode and voltage-measuring
electrode on one side of the head are part of a single electrode
structure 117, for example in the shape of a flat disk. In one
example, an annular current-carrying electrode 118 surrounds a
central voltage-measuring electrode 120, separated from it by an
annular insulating region. FIG. 1B shows the face of electrode
structure 117 which is in contact with the skin. The relatively
broad spread of the current-carrying electrode allows more current
to go through the high impedance of the skull into the low
resistance of the brain, while less current travels through the low
impedance vascularized layer of the scalp, where it might bypass
the skull and brain. To the extent that the diameter of the
current-carrying electrode is comparable to the thickness of the
scalp and skull, or at least comparable to the thickness of the
scalp, the voltage-measuring electrode will tend to be relatively
insensitive to the large voltage drop across the high resistance
epidermis and skull, and relatively more sensitive to the voltage
drop across the brain. For example, electrode structure 117 is 1 cm
in diameter, or 2 cm in diameter, or 5 cm in diameter. The
voltage-measuring and current-carrying electrodes have proportional
dimensions similar to those shown in FIG. 1B, or alternatively have
different dimensions. In an exemplary embodiment of the invention,
the other side of the disk has separate contact points, connected
respectively to the current-carrying and voltage-measuring
electrodes, suitable for attaching electrical leads, which are
connected in turn to power supply 112 and recording device 116.
Alternatively, integral lead wires are provided. Optionally,
electrode structures like that shown in FIG. 1B are used on both
sides of the head.
[0098] In an alternative embodiment, instead of electrode structure
117, electrode structure 122, shown in FIG. 1C, is used. There is
an annular current-carrying electrode 118, and a central
voltage-measuring electrode 120, as in electrode structure 117, but
there is a second voltage-measuring electrode 124, outside
current-carrying electrode 118, and optionally electrically shorted
to central voltage-measuring electrode 120. Electrode structure 122
is, for example, 1 cm in diameter, or 2 cm, or 5 cm, or has a
smaller or larger diameter. The relative proportions of the
electrodes need not be the same as the exemplary proportions shown
in FIG. 1C. The broader spread of the voltage-measuring electrode,
compared to electrode structure 117, may make the voltage
measurement even less sensitive to the voltage drop across the
epidermis and skull. Furthermore, the broad spread of the
voltage-measuring electrode, which is at a constant potential, may
tend to reduce radial electric fields and radial currents in the
scalp, and cause a greater portion of the current to flow through
the interior of the head, similar to the effect of a broadly spread
out current-carrying electrode.
[0099] In an alternative embodiment, an electrode structure 126,
shown in FIG. 1D, is used. This structure has a spiral shaped
current-carrying electrode 128 intertwined with a spiral shaped
voltage-measuring electrode 130. Depending on the details of the
geometry, electrode structure 126 potentially provides a greater
surface area for the current-carrying electrode than electrode
structures 117 or 122, thereby providing a more focused pattern of
current flow through the interior of the head, and making better
use of the available surface area. The greater surface area for
voltage-measuring electrode 130 may provide similar benefits. As
long as the widths of the different arms of the electrodes, and the
spacing between them, are at least comparable to the thickness of
the scalp and/or the skull, the voltage-measuring electrodes will
tend to be relatively insensitive to the voltage drop in the scalp
and/or the skull, as well as to any voltage drop between the
current-carrying electrodes and the skin, due to poor contact, and
will be relatively more sensitive to the voltage drop across the
brain. For example, adjacent turns of the spirals in FIG. 1D are
spaced 1 mm apart, or 2 mm, or 5 mm, and electrode structure 126
has a diameter of 1 cm, or 2 cm, or 5 cm. Electrode structures with
a variety of geometric configurations, which meet these criteria,
may provide benefits similar to those provided by one or more of
electrode structures 117, 122, and 126.
[0100] Optionally, any combination of electrode structures 117, 122
and 126 is used, as well as separate current-carrying and
voltage-measuring electrodes as shown, for example, in FIG. 1A.
Optionally, more than two electrode structures are placed on the
head, but, optionally, only two of them are used at a time to
produce current and measure voltage. These two electrode
structures, or separate sets of electrodes, need not be placed
symmetrically on opposite sides of the head, but, for example, one
could be placed over an eye socket, and one near an ear. Placing
the electrode structures in different locations may give
information about the impedance in different regions of the head.
When electrodes are placed over an eye socket, the eye is
preferably closed, for example because the patient is unconscious,
and the electrodes are placed over the eyelid.
[0101] Optionally, electrode structures such as those shown in
FIGS. 1B, 1C, and 1D, or separate electrodes such as those shown in
FIG. 1A, are placed over or near openings or thin areas of the
skull, for example the ears, the eye sockets, the temples, and the
foramen magnum. Optionally, the electrode structures or separate
electrodes are not rigid flat disks, but are flexible enough to be
molded to fit the shape of the head in those regions, or are
relatively rigid but are molded to fit the shape of the head in
those regions, optionally with some flexibility to allow them to be
adjusted to slightly different head shapes in different
individuals, with conductive gel used to fill in any small gaps.
The stiffness of the electrode structure, and the manner in which
it is attached to the skin, optionally depends on where it is
attached. For example, a softer electrode structure, exerting less
pressure, may be used over the closed eyelids, than is used over
the temples, to avoid discomfort or damage to the eyes. Optionally,
the conductive gel does not cover the entire face of the electrode
structure, but is applied only on and near the electrodes
themselves, or only on and near the current-carrying electrodes, so
that a current-carrying electrode is not shorted to an adjacent
voltage-measuring electrode.
[0102] Optionally, the electrodes come in different sizes and/or
shapes for use on different people, for example adults and
children. Optionally, different people may use the same size and
shape of electrode, but different parts of the electrode make good
contact with the skin in different people.
[0103] Dividing the voltage measured by recording device 116 by the
current produced by power supply 112 gives a measure of the
electrical impedance of interior region 106, which is related to
the blood volume in the brain. Optionally, the voltage produced by
power supply 112 is used in addition to, or instead of, the voltage
measured by recording device 116 in calculating the impedance,
possibly as a check on the reasonableness of the voltage measured
by recording device 116. But often, the voltage produced by power
supply 112 is influenced more by the skull impedance, and less by
the impedance of the interior of the head, than the voltage
measured by recording device 116. If AC current is used, then of
course the current and voltage are each expressed by a complex
number, representing the amplitude and phase. At very high
frequencies, for example above about 100 kHz, the capacitance of
the cell membranes will start to look like a short circuit, and
current will flow almost as easily through the cells as it flows
through the blood and other fluid surrounding the cells. At these
high frequencies, the impedance of the head will be less sensitive
to blood volume than it is at lower frequencies, because it will
depend on the total volume of the brain, including the cells, not
just on the volume of the blood and the extracellular fluid.
Optionally, for this reason, frequencies below about 100 kHz are
used to measure the impedance of the head. Optionally, measurements
of the relative phase of the voltage measured by recording device
116 or by power supply 112, and the current produced by power
supply 112, particularly at higher frequencies such as 100 kHz, are
used to measure the impedance of the head. Such phase measurements
are potentially useful at frequencies comparable to 100 kHz, where
the impedance of the head has a substantially capacitive component
due the cell membranes, especially if the capacitive part of the
impedance is insensitive to blood volume, or has a different
dependence on blood volume than the resistive impedance of the
head. Even if the measured impedance is affected to a large degree
by undesired effects such as the skull impedance, or the
capacitance of the cell membranes, the measured impedance is still
useful for measuring blood volume if it depends significantly on
blood volume as well.
[0104] Optionally, the impedance is never actually calculated, but
the blood volume is determined directly from the voltage data,
particularly if the current produced by power supply 112 is always
the same. Alternatively, feedback to the power supply is used to
keep the voltage measured by recording device 116 constant (i.e.
constant amplitude and phase), and the current produced by power
supply 112 is used directly to determine the blood volume. Variants
on these methods, for example, keeping some linear combination of
voltage and current the same, will be apparent to those skilled in
the art.
[0105] FIG. 2A shows a plot 200 of resistive impedance vs. time,
measured as described in FIG. 1, over a period of time covering
several pulse cycles. The vertical axis 202 represents impedance,
or resistance, and the horizontal axis 204 represents time. The
average resistance R over time has a value given by level 206 on
the vertical axis, and the variation in resistance .DELTA.R,
associated with the pulse cycle, is shown by interval 208. The
resistance decreases during the systolic phase of the pulse, when
the blood volume V of the brain is higher, and increases during the
diastolic phase when the blood volume V is lower. The relative
change in blood volume over a pulse period .DELTA.V/V is comparable
to .DELTA.R/R. If desired, the exact relation between .DELTA.V/V
and .DELTA.R/R can be calibrated for a given configuration of
electrodes by comparing measured values of .DELTA.R/R with
measurements of blood flow performed by other means known to the
art. The blood flow to the brain is found by multiplying .DELTA.V/V
by the total brain blood volume V (estimated, for example, from a
known average value for humans) and the pulse rate.
[0106] Even if a calibration is not done, or even if the
calibration is not accurate if applied to a different patient from
the calibrated patient, the estimated values of blood flow obtained
by this technique are still adequate for some applications of
interest, such as determining whether CPR is working at all, or
detecting a sudden decrease in blood flow to the brain during
surgery. If CPR is not being administered properly, or if blood
flow to the brain is reduced by a stroke or another sudden event
suffered during surgery, then the blood flow to the brain may be
essentially zero, or much lower than normal, and this may be
detected even if the technique does not measure absolute values of
blood flow very accurately.
[0107] FIG. 2B shows a closeup view of voltage-measuring electrode
114 inserted into ear canal 104. Electrode 114 is connected to
recording device 116, which analyzes the voltage data and displays
information about the head impedance and the blood flow. Electrode
114 is surrounded by a sponge 218, soaked in an electrically
conducting gel. Electrode 114 is conical in shape, and too wide at
the base to reach the ear drum when it is inserted into the ear.
Optionally, there is a system for doing optical measurements of
blood flow in the ear, combined with electrode 114. A light source
220, for example a red or infrared laser or laser diode, sends
light through optical fiber 222. Light ray 224 reflects off a
surface 226 inside the ear, for example the ear drum, or another
surface whose color is affected by blood flow and/or oxygenation of
the blood. Sponge 218 holds optical fiber 222 firmly enough in
place so that if the measurements are repeated, light ray 224
always reflects from substantially the same place, so any changes
in reflectivity are due to changes in blood flow or oxygenation,
rather than due to fiber 222 changing its position or orientation.
The reflected light goes into another optical fiber 228, which
carries it to an analyzer 230. Fiber 228 is also held firmly in
place by sponge 218. Analyzer 230 uses information about the
reflectivity of surface 226 to measure or estimate blood flow rate,
and/or the degree of oxygenation of the blood, and optionally
displays the information. Analyzer 230 and light source 220 are
optionally based on any existing system of photoplethysmography,
known to those skilled in the art. Optionally, a fiber optic cable,
comprising a plurality of optical fibers, is used instead of
optical fiber 222 and/or optical fiber 228. Optionally, fibers 222
and 228 are bundled together with the wire connecting electrode 114
to recording device 116. Optionally, analyzer 230 is packaged
together with recording device 116. Optionally, data from analyzer
230 is combined with data from recording device 116, and a single
estimate of blood flow is displayed, based on the combined data.
Optionally, a probe comprising fibers 222 and 228, and sponge 218
or a similar element to hold the probe in place, is used for
optical measurements in the ears, even if voltage-measuring
electrodes 114 are not placed in the ears.
[0108] A different method of inducing currents in the brain and
measuring voltages is illustrated in FIGS. 3A, 3B, and 3C, which
show coils placed around the head in different orientations, to
induce currents in the brain. Other magnetic induction methods may
be used as well, including different coil configurations, or the
use of rotating or oscillating permanent magnets or electromagnets
to produce time-varying magnetic fields in the head. Measuring the
induced currents, by measuring their effects on the induced
magnetic and electric fields, gives information about the impedance
of the brain, and hence the blood volume of the brain. In FIG. 3A,
coils 302, one on each side of the head, have AC current flowing in
them, driven by power supply 304, and generate an AC magnetic field
inside the head. The changing magnetic flux induces electric fields
in the head which are parallel to the currents in coils 302, but in
the opposite direction. The AC magnetic field optionally is large
enough so that the induced electric fields are large enough to
produce measurable effects, as discussed below, but small enough
not to produce peripheral or central nerve stimulation. Optionally,
the threshold for nerve stimulation is increased by using trains of
short pulses, or other methods known to the art, so that higher AC
magnetic fields can be used. The induced electric fields cause eddy
currents to flow in the brain, of an amplitude which depends on the
impedance of the brain. The eddy currents in turn generate their
own magnetic field and an associated induced electric field,
reducing the magnetic flux inside the brain. Coils 306 measure a
voltage associated with the AC magnetic flux produced by coils 302,
and this voltage is recorded by recording device 308. The reduction
in magnetic flux caused by the eddy currents flowing in the brain
can be detected by recording device 308, since the induced voltage
will be lower, i.e. the mutual inductance between coils 302 and
coils 306 will be reduced. The eddy currents will also give the
mutual inductance an imaginary (dissipative) part, which may be
easier to detect than the reduction in the real part of the mutual
inductance. An estimate of the absolute impedance of the brain may
be made by observing how the mutual inductance of coils 302 and 306
changes with the frequency of the AC current. Even without making
such an absolute estimate of the impedance of the brain, changes in
impedance of the brain over time, during the pulse cycle, may be
detected by observing the changes in mutual inductance during the
pulse cycle.
[0109] Optionally, the electric fields induced by coils 302 are
measured by electrodes placed on or in the head, similar to the
voltage-measuring electrodes shown in FIGS. 1A and 2B. The
electrodes are shaped and sized, for example, to be placed in the
ears or in the nose, or to be placed on the temples or elsewhere on
the head, with electrically conducting gel. The induced electric
field depends on the impedance of the brain, because it is modified
by the eddy currents which depend on the impedance of the
brain.
[0110] Here are some considerations used in choosing the frequency
of the AC current in coils 302. For a brain resistivity of 2
ohm-meters, typical of body tissue, the magnetic field produced by
the eddy currents, which depends on the impedance of the brain,
will be comparable to the magnetic field produced by the induction
coils when the skin depth of the brain is comparable to its radius,
about 10 cm. This occurs at a frequency of about 50 MHz. At
frequencies well above 100 kHz, however, the impedance of the cell
membranes may be effectively shorted out, so that current flows
freely inside as well as outside the cells, so the resistivity of
the brain is somewhat lower, and eddy currents become important at
about 30 MHz. The impedance of the brain at such high frequencies
is less sensitive to blood volume than it is below 100 kHz, due to
the conduction pathway going inside the cells, but the impedance is
still somewhat sensitive to blood volume, since the total volume of
fluid in the brain, inside and outside cells, still increases when
the blood volume increases. Optionally, frequencies of about 10
MHz, or a few tens of MHz, or even about 100 MHz, are used, since
the blood volume may have the greatest effect on eddy currents in
this frequency range. At frequencies well above 30 MHz, eddy
currents may largely exclude magnetic flux from the interior of the
brain, and the mutual inductance of the coils may be less sensitive
to blood volume. Optionally, the frequencies used are low enough so
that the eddy currents do not reduce the magnetic field at any
point inside the head by more than a factor of 1.5. Alternatively,
the eddy currents do not reduce the magnetic field by more than a
factor of 3, or by more than a factor of 6. At frequencies well
below 30 MHz, the small change in the real part of the mutual
inductance might be difficult to detect, but the change in the
dissipative part, which is proportional to frequency well below 30
MHz, might be relatively easy to detect, even below 100 kHz, if it
is the dominant dissipative term. Optionally, frequencies between a
few tens of kHz, about 100 kHz, or a few hundred kHz are used,
since they are easier to work with than frequencies of a few tens
of MHz, and may still provide sufficient sensitivity to blood
volume. Alternatively, frequencies of a few hundred kHz, about 1
MHz, or a few MHz are used, since they may provide the best
trade-off between sensitivity and ease of use.
[0111] Eddy currents at different frequencies may have different
spatial distributions in the brain, both because of skin effects
(differing mostly at frequencies above 1 MHz), and because of the
finite capacitance of cell membranes (differing mostly at
frequencies below 1 MHz). Eddy currents may also have a different
distribution in the brain than currents produced by electrodes
placed on the head. Different distributions of current may provide
different data about the distribution of blood in the head, for
example in a patient with a cerebral hemorrhage where blood can
pool locally at one or more locations. Optionally, eddy currents
are induced at more than one frequency, or both coils and
electrodes are used to induce currents in the brain, in order to
obtain more data about the distribution of blood in the brain.
[0112] Optionally, the currents in induction coils 302 are of a
magnitude small enough not to cause peripheral or central nerve
stimulation, or to cause deleterious health effects or discomfort
from heating of the brain or other body tissues. The maximum safe
currents, which depend on the frequency and duration of the
currents, are well known to those skilled in the art, in the field
of magnetic resonance imaging for example. Optionally, the currents
used are only a few times less than the maximum safe currents, or
even only a few percent less than the maximum safe currents, and
not many times less, in order not to sacrifice precision of the
measurements.
[0113] Optionally, instead of using separate coils 306 to detect
the induced voltage, coils 302 are used to detect the induced
voltage, i.e. the self-inductance of coils 302 is used, instead of
the mutual inductance between coils 302 and 306. However, a
possible advantage of using mutual inductance rather than
self-inductance is that the voltage in coils 306 will not be
sensitive to the resistance of coils 302, or the resistance of
coils 306 if recording device 308 has a high impedance. In
particular, the dissipative part of the mutual inductance may be
the dominant dissipative term in the voltage measured the recording
device 308, making it easy to measure. On the other hand, if
self-inductance of coils 302 were used, the dissipative part of the
inductance would likely be small compared to the resistance of the
coils, and difficult to measure.
[0114] Alternatively or additionally, the magnetic fields produced
by the coil currents and by the eddy currents in the brain are
measured by magnetic sensors such as Hall sensors, flux gate
magnetometers, or SQUIDs. Such magnetic sensors will give more
local magnetic field measurements than large coils encircling the
head, and may give data that is weighted toward local changes in
blood flow, possibly complementing the more global data from large
coils. Global data is also optionally obtained by averaging the
results from several local magnetic sensors.
[0115] FIG. 3A shows two coils 302 on the sides of the head, and
two coils 306, near the midplane of the head, but going around
opposite sides of the neck. However, the coils need not be arranged
symmetrically as shown. Optionally, there is only one coil 302, or
only one coil 306. Optionally, coils 302 are close to the midplane
of the head, and coils 306 are located on the sides of the head. An
optimal configuration of coils can optionally be found by using
magnetic finite element methods, or other numerical or analytic
methods known to the art.
[0116] FIGS. 3B and 3C show coils 302 and 306 oriented in other
directions with respect to the head. In addition to obtaining
adequate mutual inductance between the coils, and adequate
dependence of the mutual inductance on the impedance of the brain,
another consideration in choosing the coil orientation is the
ability to keep the coils positioned rigidly with respect to the
head. Changes in position of the coils will affect their mutual
inductance and self-inductance, and may appear as spurious changes
in calculated brain impedance.
[0117] FIG. 4 shows coils 402 arranged in front and back of a head,
as in FIG. 3B, and a coil 406 going around the head from to top to
under the chin, to measure the flux induced by coils 402. The brain
410 is shown inside the head. When currents 412 in coils 402 are
flowing in one direction, induced eddy currents 414 flow in the
brain in the opposite direction, but the two currents are less than
180 out of phase. (Similar induced eddy currents in the brain would
also be seen with the coil configurations shown in FIG. 3A or 3C,
but the currents would be flowing in different directions,
generally opposite to the currents flowing in the coils.) Currents
414 reduce the magnetic flux inside the brain, and reduce the total
flux passing through coils 402 and 406. Currents 414 also change
the phase of the flux passing through coils 402 and 406, relative
to the phase of current 412 in coils 402. This change in amplitude
and phase of the flux is detected by coil 406 as a change in the
amplitude and phase of the voltage of coil 406, relative to the
amplitude and phase of current 412. Thus the amplitude and phase of
the voltage in coil 406 provides information about the impedance of
brain 410.
[0118] Optionally, a C-shaped element of high magnetic
permeability, not shown in the drawings, extends between the two
coils 302 in any of FIG. 3A, 3B, or 3C, in order to increase the
magnetic field induced in the brain, for a given current in coils
302. This would reduce the size and cost of the required power
supply, and reduce the ohmic heating of the coils, to produce a
given magnetic field and induced electric field in the brain. Such
a C-shaped element could, however, have the potential disadvantage
of introducing an additional source of dissipation, due to eddy
currents and hysteresis in the magnetic material, that might make
it more difficult to detect the eddy currents introduced in the
brain by coils 302, and many high permeability alloys have lower
permeability at high frequencies, especially above 1 MHz.
Optionally the C-shaped element is laminated, to reduce eddy
currents and increase the effective permeability at a given
frequency. Optionally, the C-shaped element is made of vanadium
permendur, or a similar alloy with low magnetic anisotropy, because
its permeability may not fall off as much at high frequencies as is
the case with other high permeability materials.
[0119] FIGS. 5A and 5B illustrate portable embodiments of the
invention that are potentially suitable for use in the field, in
contrast to non-portable embodiments of the invention that are
suitable for use in a hospital setting during surgery, for example.
Assemblies 502 contain both current-carrying and voltage-measuring
electrodes, either placed on the temples, as in FIG. 5A, or on the
ears, and with the voltage-measuring electrodes optionally inserted
into the ears, as in FIG. 5B. Optionally, assembly 502 on each side
of the head covers the ears, resembling earmuffs, with
current-carrying electrodes outside the ears and voltage-measuring
electrodes inside the ears. Optionally, there is more than one
current-carrying electrode on each side. Optionally, some of the
electrodes are placed on the temples or elsewhere on the head, and
some of them are placed on or in the ears.
[0120] Alternatively or additionally, assemblies 502 contain coils
which induce eddy currents in the brain, and coils or other
magnetic sensors which detect the eddy currents. Optionally, if
assemblies 502 contain coils, they are substantially bigger than
shown in FIGS. 5A and 5B, in order to produce a magnetic field that
is more uniform in the brain, rather than concentrated near the
assemblies, and in order to reduce the ohmic power generated by the
coils when producing a given magnetic field. Alternatively, the
coils are small, and are inserted into the ears, particularly for
making local measurements of impedance near the ears.
[0121] Monitor 504 optionally displays the blood volume or blood
flow rate as a function of time, determined from the impedance
measurements. Alternatively or additionally, monitor 504 has
warning lights, for example a green light which lights up when the
blood flow rate to the brain is satisfactory, and a red light which
lights up, and/or a buzzer which sounds, when the blood flow rate
is too low, or changes suddenly. Optionally, monitor 504 has five
or fewer warning lights, to minimize the information that an
emergency medical technician has to sift through, when looking at
the monitor.
[0122] Optionally, a power supply is packaged together with monitor
504. Alternatively, there is a separate power supply, not shown in
FIGS. 5A and 5B.
[0123] FIG. 6 shows a similar embodiment of the invention, but with
monitor 504 mounted on the patient's forehead. Alternatively, there
are two monitors, one mounted on the patient's forehead which, for
example, has only a few warning lights, and one not mounted on the
patient which displays more information.
[0124] Optionally, any of recording device 116 in FIGS. 1A and 2B,
power supply 112 in FIG. 1A, analyzer 230 in FIG. 2B, power supply
304 in FIGS. 3A, 3B, and 3C, recording device 308 in FIGS. 3A, 3B
and 3C, and monitor 504 in FIGS. 5A, 5B and 6, comprise a
controller, which controls the currents sent to the
current-carrying electrodes or coils, and analyzes the data.
Optionally, the controller includes any of a CPU, power
electronics, an AC/DC converter, and non-volatile memory to store
software and data. Optionally, different elements of the controller
are located in different places, for example the power supply and
the recording device, and/or the controller or parts of the
controller are packaged separately.
[0125] These portable versions could be used, for example, during
the administration of CPR by emergency medical technicians, to
monitor whether the CPR is being administered effectively. Studies
(for example, S. Braunfels, K. Meinhard, B. Zieher, K. P. Koetter,
W. H. Maleck, and G. A. Petroianu, "A randomized, controlled trial
of the efficacy of closed chest compressions in ambulances,"
Prehosp. Emerg. Care 1997 July-September; 1(3):128-31) have shown
that, in the absence of feedback, CPR is often administered
ineffectively.
[0126] In any of the above mentioned embodiments of the invention,
motion of the head relative to the electrodes, coils, or sensors
can produce a spurious change in measured blood volume, and hence a
spurious calculated blood flow. Various methods are optionally used
to reduce such motion artifacts. For example, the effect of any
motion that is not correlated with the pulse cycle is optionally
reduced by averaging over time. Such averaging will not eliminate
motion artifacts in the calculated blood flow due to motion that is
correlated with the pulse, such as motion associated with the
administration of CPR. Motion artifacts are also optionally reduced
by keeping the head immobilized, and keeping the electrodes, coils,
and sensors rigidly in place against the head. Optionally, motion
artifacts are compensated for by using an accelerometer to detect
motion of the head, and modeling the motion artifacts, or by only
using data taken when the head is not moving too much. Additionally
or alternatively, a pulse detected in the neck is used to
distinguish motion artifacts from the real effects of blood flow in
the brain, even if the pulse in the neck is not usable for
measuring blood flow directly.
[0127] Potential applications of these techniques for measuring
blood flow in the brain may best be served by adapting the device
to each application. For example:
[0128] 1) For emergency medical situations such as arrhythmia,
myocardial infarction, cardiac arrest, or traumatic hemorrhagic
shock, the device is optionally made portable, with a
self-contained power supply, perhaps battery operated, and/or has a
monitor with only limited information displayed.
[0129] 2) For follow-up of traumatic brain injury patients, the
device optionally is portable enough and rugged enough for home
use, using a battery or AC power from a wall outlet, and/or has a
monitor that is simple enough to be used by the patient or a family
member with little training, and optionally also displays
additional information that could be used, for example, by a
visiting nurse.
[0130] 3) For monitoring blood flow to the brain prior to and
during surgical procedures, especially carotid endarectomy, the
device need not be portable or could be moved around on a cart, and
optionally displays data that would be of interest to the surgeon
or other medical personnel in the operating room, so that changes
can be made in the surgical procedure in real time, in response to
a decrease in blood flow, for example.
[0131] 4) For monitoring patients suffering from diseases such as
stroke, syncope, and sickle cell anemia, where disturbances in
cerebral blood flow often occur, the device optionally measures
local blood flow in different regions of the brain, and optionally
comes in different versions, one for hospital use, for example in
an intensive care unit, and one for long term monitoring at
home.
[0132] 5) For cardiopulmonary resuscitation (CPR), to verify that
it is working effectively, the device optionally integrates the
blood flow in the brain after every few chest compressions, for
example every time the lungs are expanded, and prominently displays
the result on a large dial or array of lights, so the person
administering CPR can immediately see whether the chest
compressions are too weak or too strong, or too slow or too fast,
or whether the heart has started beating on its own. A portable
version of the device is optionally used by emergency medical
technicians in the field or in an ambulance. A less portable
version, on a cart for example, is optionally used in a hospital
emergency room.
[0133] For these applications, accurate measurements of blood flow
to the brain are not necessarily needed, but it is important to
detect large changes in blood flow, or the presence or absence of
blood flow. The potential for low cost of the system, and the fact
that it can be used by someone with relatively little training, is
important for these applications, especially for CPR. Other
potential advantages of this technique over existing methods of
measuring blood flow in the brain, for example TCD, include the
fact that it measures blood flow continuously in real time, the
fact that it operates automatically without the need for an
operator whose sole function is to run the equipment, the fact that
it measures global rather than local blood flow, and the small size
and portability of the equipment in some embodiments of the
invention.
[0134] As used herein, "two portions of a same electrode" includes
the case of two separate electrodes that are electrically shorted
together.
[0135] The invention has been described in the context of the best
mode for carrying it out. It should be understood that not all
features shown in the drawings or described in the associated text
may be present in an actual device, in accordance with some
embodiments of the invention. Furthermore, variations on the method
and apparatus shown, which will be readily apparent to and may be
readily accomplished by persons skilled in the art, are included
within the scope of the invention, which is limited only by the
claims. Also, features of one embodiment may be provided in
conjunction with features of a different embodiment of the
invention. The words "comprise", "include" and their conjugates as
used herein mean "include but are not necessarily limited to".
* * * * *