U.S. patent application number 13/107947 was filed with the patent office on 2011-09-01 for method for producing tablet comprising natural allicin.
Invention is credited to Ying YAO.
Application Number | 20110212082 13/107947 |
Document ID | / |
Family ID | 40244342 |
Filed Date | 2011-09-01 |
United States Patent
Application |
20110212082 |
Kind Code |
A1 |
YAO; Ying |
September 1, 2011 |
METHOD FOR PRODUCING TABLET COMPRISING NATURAL ALLICIN
Abstract
A method for producing a tablet including mixing and uniformly
stirring starch, garlic powder, and natural allicin powder to yield
a mixture, adding natural sesamin, Ig Y or Ig G, and magnesium
stearate to the mixture, uniformly stiffing, and tabletting. The
allicin tablet has high allicin content and capability of
anti-bacteria and anti-inflammation, and can be administered based
on the body weight of an animal in need thereof but causes no side
effects.
Inventors: |
YAO; Ying; (Hangzhou,
CN) |
Family ID: |
40244342 |
Appl. No.: |
13/107947 |
Filed: |
May 15, 2011 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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12943034 |
Nov 10, 2010 |
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13107947 |
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PCT/CN2009/072602 |
Jul 2, 2009 |
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12943034 |
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Current U.S.
Class: |
424/130.1 |
Current CPC
Class: |
A61K 31/095 20130101;
A61K 39/395 20130101; A61P 31/12 20180101; A61K 45/06 20130101;
A61K 31/105 20130101; A61P 1/04 20180101; A61P 13/12 20180101; A61P
31/00 20180101; A61P 29/00 20180101; A61P 31/04 20180101; A61K
9/2059 20130101; A61K 36/88 20130101; A61K 36/8962 20130101; A61K
31/36 20130101; A61K 31/357 20130101; A61K 31/255 20130101; A61K
31/10 20130101; A61K 31/21 20130101; A61P 11/02 20180101; A61P
13/02 20180101; A61P 9/00 20180101; A61P 1/02 20180101; A61K 31/095
20130101; A61K 2300/00 20130101; A61K 31/10 20130101; A61K 2300/00
20130101; A61K 31/105 20130101; A61K 2300/00 20130101; A61K 31/21
20130101; A61K 2300/00 20130101; A61K 31/255 20130101; A61K 2300/00
20130101; A61K 31/357 20130101; A61K 2300/00 20130101; A61K 31/36
20130101; A61K 2300/00 20130101; A61K 36/88 20130101; A61K 2300/00
20130101; A61K 36/8962 20130101; A61K 2300/00 20130101; A61K 39/395
20130101; A61K 2300/00 20130101 |
Class at
Publication: |
424/130.1 |
International
Class: |
A61K 39/395 20060101
A61K039/395; A61P 31/04 20060101 A61P031/04; A61P 9/00 20060101
A61P009/00 |
Foreign Application Data
Date |
Code |
Application Number |
Jul 3, 2008 |
CN |
200810062759.7 |
Claims
1. A method for producing a tablet comprising 1,000 weight parts of
21-90% a natural allicin powder, 10-30 weight parts of 50-95%
sesamin, 10-30 weight parts of 50-95% IgY or IgG, and a release
agent, the allicin content of said tablet being 200-800 mg/g; the
method comprising mixing and uniformly stiffing said starch, said
garlic powder, and said natural allicin powder to yield a mixture,
adding said natural sesamin, Ig Y or Ig G, and said magnesium
stearate to said mixture, uniformly stiffing, and tabletting.
2. The method of claim 1, further comprising adding a cool or cold
food additive to said mixture.
3. The tablet of claim 2, wherein said cool or cold food additive
is an extract from mungbean sprout or lily.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a divisional of U.S. Ser. No. 12/943,034
filed on Nov. 10, 2010, now pending, which is a National Stage
Application of International Patent Application No.
PCT/CN2009/072602, with an international filing date of Jul. 2,
2009, which is based on Chinese Patent Application No.
200810062759.7, filed Jul. 3, 2008. The contents of all of these
specifications are incorporated herein by reference.
BACKGROUND OF THE INVENTION
[0002] 1. Field of the Invention
[0003] The invention relates to a method for producing a tablet
comprising natural allicin.
[0004] 2. Description of the Related Art
[0005] Natural allicin is a mixture mainly composed of
diallyltrisulfide, diallyl disulfide, diallyl-thiosulfinate,
ajoene, and vinyldithiins. Generally, the allicin content refers to
the total amount of the above mentioned five active ingredients.
Natural allicin is extracted from garlic and plays a role something
like broad-spectrum antibiotics and a vascular cleaner orprotector.
Thus, it exhibits strong medicinal functions.
[0006] As a vascular protector, a daily intake of between 5 and 80
mg of allicin is enough for a grownup. However, if functioning as
broad-spectrum antibiotics to kill infectious viruses and bacteria,
the administered allicin must be large, for example, exceeding 200
mg per time per 10 kg of body weight. Conventional allicin tablets
contain a limited dose of allicin, for example, 20 mg or 25 mg of
allicin per piece, and the dosage is 2-3 times per day with 2-6
pieces per time. Many practices have proved the fact that the
prevention and treatment effect on worse diseases caused by viruses
or bacteria is poor when the intake amount does not exceed 120 mg
each time for people. Obviously, the dosage amount is not enough
for preventing and treating diseases. However, administering a
large amount of allicin one time is harmful to body. Experiments
showed that a large amount of allicin collapsed the heart of mice
or rabbits. If a human was administered with 700 mg or more of
natural allicin (i.e, 1,000 mg of a 70% concentrated natural
allicin extract) alone, the chest and abdomen swelled and made him
uncomfortable. The more allicin was ingested, the larger the
swelling that was observed. Thus, it is urgent to develop an
allicin tablet which can be administered largely within an
effective dosebut causes no harm to human body.
SUMMARY OF THE INVENTION
[0007] In view of the above-described problems, it is one objective
of the invention to provide a tablet that comprises high content of
allicin, can be administered according to the body weight of a
human in need thereof, involves no artificial chemicals, and
exhibits good effect on anti-bacteria, anti-inflammation, and
anti-virus.
[0008] To achieve the above objectives, in accordance with one
embodiment of the invention, there is provided a tablet comprising
1,000 weight parts of 21-90% natural allicin powder, 10-30 weight
parts of 50-95% sesamin, 10-30 weight parts of 50-95% IgY or IgG,
and a release agent, the allicin content of the tablet being
200-800 mg/g.
[0009] In accordance with another embodiment of the invention,
there is provided a tablet comprising 1,000 weight parts of 62-80%
natural allicin powder, 20-80 weight parts of 50-95% sesamin, 20-80
weight parts of 50-95% IgY or IgG, 38-460 weight parts of starch,
100-1500 weight parts of garlic powder, and a release agent, the
allicin content of the tablet being 200-600 mg/g.
[0010] In a class of this embodiment, the release agent is
magnesium stearate.
[0011] In a class of this embodiment, the tablet comprises 1,000
weight parts of 62-80% natural allicin powder, 20-80 weight parts
of 50-95% sesamin, 20-80 weight parts of 50-95% IgY or IgG, 340-460
weight parts of starch, 550-1500 weight parts of garlic powder, and
6 weight parts of magnesium stearate, and the allicin content of
the tablet is 200-400 mg/g.
[0012] In a class of this embodiment, the tablet comprises 1,000
weight parts of 62-80% natural allicin powder, 20-70 weight parts
of 50-95% sesamin, 20-70 weight parts of 50-95% IgY or IgG, 80-460
weight parts of starch, 460-550 weight parts of garlic powder, and
4 weight parts of magnesium stearate, and the allicin content of
the tablet is 300-500 mg/g.
[0013] In a class of this embodiment, the tablet comprises 1,000
weight parts of 62-80% natural allicin powder, 20-50 weight parts
of 50-95% sesamin, 20-50 weight parts of 50-95% IgY or IgG, 38-80
weight parts of starch, 200-460 weight parts of garlic powder, and
3 weight parts of magnesium stearate, and the allicin content of
the tablet is 400-600 mg/g.
[0014] In a class of this embodiment, the tablet comprises 1,000
weight parts of 62-80% natural allicin powder, 20-40 weight parts
of 50-95% sesamin, 20-40 weight parts of 50-95% IgY or IgG, 38
weight parts of starch, 100-190 weight parts of garlic powder, 2
weight parts of magnesium stearate, and 10-100 weight parts of a
cool or cold food additive, and the allicin content of the tablet
is 400-600 mg/g.
[0015] In a class of this embodiment, the cool or cold food
additive is corn, wheat, barley, buckwheat, coix Seed, millet, mung
bean, green bean sprouts, bitter melon, white fungus, seaweed,
lettuce, aloe vera, white radish, asparagus, celery, water bamboo,
coriander, white gourd, lily, towel gourd, spinach, amaranth, water
spinach, fern, dandelion, clover blossom, sugar beet, sweet potato,
konjak, water pack, eggplant, daylily, mushroom, cucumber,
watermelon, melon, banana, rape, water chestnuts, water chestnut
meat, lotus root, lotus seed, nelumbinis embryo, green tea,
chrysanthemum, honeysuckle, apple, pear, orange, persimmon,
hylocereusundatus fruit, star fruit, mangosteen, strawberries,
loquat, cherry tomato, medlar, grapefruit, kiwi fruit, soft-shelled
turtle, turtle, duck, frog, jellyfish, snail, crab, clam, mussel,
snakehead, snail, snake, or a mixture thereof, among which an
extract from mungbean sprout or lily is preferable. The extract
content is 40-95%.
[0016] In a class of this embodiment, the allicin content of the
natural allicin power is 65-75%.
[0017] The preparation method of the cool or cold food additive
comprises grinding a raw material, extracting with liquor,
filtering, removing residue and alcohol, and freeze-dryingto yield
a powder or powder block.
[0018] The 21-90% natural allicin powder was purchased from
Hangzhou Shenzhou Earth Ecology Culture Institute.
[0019] As far as traditional Chinese medicine is concerned, garlic
is hot-natured, so the natural allicin tablet is particularly
suitable for humans with a cool- or cold-natured body. For humans
with a hot-natured body, the above-mentioned cool or cold food
additive can be added to the tablet. If the tablet comprises no
cool or cold food additive, humans with a hot-natured body can eat
sufficient cool or cold food when administering the tablet.
[0020] A method for producing the allicin tablet comprises mixing
the materials, uniformly stirring, and tabletting.
[0021] Another method for producing the allicin tablet comprises
mixing and uniformly stirring starch, garlic powder, and natural
allicin powder, adding natural sesamin, Ig Y or Ig G, the release
agent, and the cool or cold food additive, uniformly stirring, and
tabletting.
[0022] The release agent ensures the molds to be easily released
and not sticky in the process of tabletting, the addition amount
thereof is not related to the allicin content.
[0023] The prepared allicin tablet is 1,000 mg/piece (1 g/piece),
with allicin content of 200-700 mg/piece. The tablet can be
administered according to body weight, i.e., one piece/10 kg body
weight, 2-3 times per day.
[0024] The allicin tablet has high content of allicin. Clinical
applications have shown that for a seriously-ill patient, natural
allicin can weaken the diseases but the administered dosage must be
large. Generally, the dosage is 200-700 mg/10 kg body weight. For
example, for a person with weight body of 50 kg, the oral dosage of
natural allicin should be 1,000-3,500 mg per time, and 2-3 times a
day. The allicin tablet can effectively kill inflammation, viruses,
and infectious bacteria, without side effects and drug resistance.
Thus, it is very safe and moderate.
[0025] Conventional Chinese medicine pays good attention to the
compatibility of different active ingredients. Pure allicin
extracted from garlicis separated from other components therein.
Thus, when administering to human body alone, people fall into an
unbalanced and uncoordinated state. The purer in concentration or
higherin quantity of the allicin, the worse the balance and the
coordination. However, after mixed with a garlic powder, the
allicin seems to recombine with other components of the garlic.
High content of allicin together with other trace elements and
nutritious components protects human body harmoniously and
effectively.
[0026] Single allicin can prevent and weaken diseases caused by
nearly all the bacteria or virus, but a few of cases showed some of
bacteria or virus cannot be rooted up if intaking allicin singly.
The addition of a little sesamin can reach the effect and the
treatment effect comes much sooner. If a little IgG or IgY is
added, the effect is much better. The allicin, sesamin, and IgG or
IgY are compatible with each other and can be administered largely
within an effective dose but cause no side effects to human body.
The ingredients that are admixed with allicin and the proportions
thereof are critical to ensuring optimal health benefits without
side effects. The invention of the allicin tablet frees people from
the over-dependence on chemical antibiotics as soon as
possible.
BRIEF DESCRIPTION OF THE DRAWINGS
[0027] The invention is described herein below with reference to
accompanying drawings, in which FIGS. 1-4 show HPLC (High
performance liquid chromatography) traces of an allicin powder
according to one embodiment of the invention.
DETAILED DESCRIPTION OF THE EMBODIMENTS
[0028] To further illustrate the invention, experiments detailing
an allicin tablet, a preparation method, and the use thereof are
described below. It should be noted that the following examples are
intended to describe and not to limit the invention.
[0029] The 30-90% natural allicin powder used in following examples
is produced and sold by Hangzhou Shenzhou Earth Ecology Culture
Institute with a concentration of 30-90%. A sample is examined by
Zhejiang University and Zhejiang Food Quality Supervision and
Inspection Station. The examination results are listed in Tables
1-3.
TABLE-US-00001 TABLE 1 Sensory evaluation of the natural allicin
powder produced by Hangzhou Shenzhou Earth Ecology Culture
Institute Items Results Appearance Light yellow solid powder Smell
A little garlic smell, no odour Flavor A little garlic taste, no
odour Degree of fineness 80 mesh
[0030] Due to different garlic origin or production time, the
natural allicin powder is milk white, light yellow, or brown.
TABLE-US-00002 TABLE 2 Sanitary evaluation of the natural allicin
powder produced by Hangzhou Shenzhou Earth Ecology Culture
Institute Items Unit Standard value Measured value Results Negative
% .ltoreq.9 0 Satisfied deviation of net content Impurity % / 0.05
Satisfied Moisture % <9 3.26 Satisfied Ash % .ltoreq.6 2.66
Satisfied Heavy metal mg/kg .ltoreq.5.0 1.03 Satisfied (Hg + Pb)
CFU cfu/g <30000 <10 Satisfied E. coli MPN/100 g <90
<30 Satisfied Mould cfu/g <25 <10 Satisfied Yeast cfu/g
<25 <10 Satisfied Pathogen / Prohibited Not found
Satisfied
TABLE-US-00003 TABLE 3 Content measurement of
diallyltrisulfide(C.sub.6H.sub.10S.sub.3) of the natural allicin
powder produced by Hangzhou Shenzhou Earth Ecology Culture
Institute Sample Allicin content Allicin content Item dissolution
rate in sample solution in sample solid Content of allicin 66%
66.5371% 43.91%
[0031] The measurement result of diallyltrisulfide is shown in
FIGS. 1-4 in which the peak value represents the content of
C.sub.6H.sub.10 S.sub.3.
Example 1
[0032] 500 g of 65-70% natural allicin powder, 230 g of starch, and
230 of a garlic powder were mixed and stirred to yield a uniform
mixture. To the uniform mixture, 20 g of 65% natural sesamin, 20 g
of 80% IgG, and 2 g of magnesium stearate were added, stirred
uniformly, and tabletted. The resultant mixture was 1,002 g in
weight and tabletted into 1,002 pieces. Each piece was 1 g, with
allicin content exceeding 300 mg, generally between 324 and 350
mg.
Example 2
[0033] 1,000 g of 65-70% natural allicin powder, 20 g of 65%
natural sesamin, 20 g of 80% IgY, and 2 g of magnesium stearate
were mixed, stirred uniformly, and tabletted. The resultant mixture
was 1,042 g in weight and tabletted into 1,042 pieces. Each piece
was 1 g, with allicin content exceeding 600 mg, generally between
634 and 685 mg.
Example 3
[0034] 1,000 g of 65-70% natural allicin powder, 350 g of starch,
and 1,500 of a garlic powder were mixed and stirred to yield a
uniform mixture. To the uniform mixture, 60 g of 70% natural
sesamin, 60 g of 80% IgY, and 6 g of magnesium stearate were added,
stirred uniformly, and tabletted. The resultant mixture was 2,976 g
in weight and tabletted into 2,976 pieces. Each piece was 1 g, with
allicin content exceeding 200 mg, generally between 218 and 235
mg.
Example 4
[0035] 1,000 g of 65-70% natural allicin powder, 450 g of starch,
and 550 of a garlic powder were mixed and stirred to yield a
uniform mixture. To the uniform mixture, 40 g of 70% natural
sesamin, 40 g of 80% IgY, and 4 g of magnesium stearate were added,
stirred uniformly, and tabletted. The resultant mixture was 2,084 g
in weight and tabletted into 2,084 pieces. Each piece was 1 g, with
allicin content exceeding 300 mg, generally between 312 and 336
mg.
Example 5
[0036] 1,000 g of 65-70% natural allicin powder, 50 g of starch,
and 450 of a garlic powder were mixed and stirred to yield a
uniform mixture. To the uniform mixture, 30 g of 70% natural
sesamin, 30 g of 80% IgY, and 3 g of magnesium stearate were added,
stirred uniformly, and tabletted. The resultant mixture was 1,563 g
in weight and tabletted into 1,563 pieces. Each piece was 1 g, with
allicin content exceeding 400 mg, generally between 416 and 448
mg.
Example 6
[0037] 1,000 g of 65-70% natural allicin powder, 38 g of starch,
and 160 of a garlic powder were mixed and stirred to yield a
uniform mixture. To the uniform mixture, 20 g of 70% natural
sesamin, 20 g of 80% IgY, 40 g of a 70% cool food additive, and 2 g
of magnesium stearate were added, stirred uniformly, and tabletted.
The resultant mixture was 1,280 g in weight and tabletted into
1,280 pieces. Each piece was 1 g, with allicin content exceeding
500 mg, generally between 508 and 547 mg.
Example 7
[0038] 18 white rabbits (all were 1 kg in body weight) suffering
from bacillary dysentery were divided into three groups (Group A,
B, and C) randomly. The rabbits were treated separately. The
treatment method and the results are shown in Table 4.
TABLE-US-00004 TABLE 4 Group Treatment Results A 100 mg of an
allicin tablet Diarrhea disappeared on the with allicin content of
treatment day. After between 30 and 70 mg was administration on the
next day, administered, a piece one all the six rabbits recovered
time, three times per day. completely. B 100 mg of an allicin
tablet Diarrhea weakened on the with allicin content less than
treatment day. On the next day, 30 mg was administered, a diarrhea
disappeared. On the 3.sup.rd piece one time, three times day, all
the six rabbits recovered per day. completely. C No allicin was
administered. All the six rabbits died.
Example 8
[0039] Eight German shepherd puppies suffered from plague, two of
which were treated with injections and medicine without allicin,
finally died. The rest six were at their last gasp and could not
stand up. The allicin tablet of the invention was administered to
the six puppies, three times a day. On the first administration
day, the puppies stood up, walked around, and took food. On the
3.sup.rd day, the puppies recovered completely, with good appetite
and walked smoothly. In the process of treating the six puppies, no
injections and medicine involved.
Example 9
[0040] The following are clinical cases about the treatment effect
of the natural allicin tablet on patients.
[0041] 1. The natural allicin tablet was administered to nine
patients catching a cold. After an hour, cold symptoms were
alleviated. After three times' administration, the patients
recovered completely.
[0042] 2. A nephritis patient had high content ofurine protein.
After 15 days' administration of the natural allicin tablet, the
urine protein content decreased greatly and fell into the normal
range.
[0043] 3. A patient almost recovered from leukemia after hospital
treatment. However, the disease relapsed soon and worsened. He had
a fever everyday and severe oral ulcer. The natural allicin tablet
was administered to the patient. Three days later, his body
temperature was back to normal and the oral ulcer disappeared.
[0044] 4. A lymphoma patient experiencing chemotherapy had severe
oral ulcer and could not eat. Nothing but the natural allicin
tablet was administered to the patient. Four days later, the oral
ulcer disappeared.
[0045] 5. A nasopharyngeal carcinoma patient experiencing
chemotherapyhad severe oral ulcer. Chinese medicine and
anti-inflammatory drugs were tried but had no effect. The natural
allicin tablet was administered to the patient. Four days later,
the oral ulcer disappeared.
[0046] 6. A liver and intestinal cancer patient was administered
with eight bottles of the allicin tablet of the invention and
twelve bottles of common allicin tablet. The disease weakened with
passing day and the liver ache almost disappeared.
[0047] 7. A patient whose liver ached sometimes for several days
was administered with the allicin tablet of the invention. Two days
later, the ache disappeared.
[0048] 8. A patient had yellow and smellyleucorrhea. Many
anti-inflammatory and anti-bacterial drugs were tried but had no
effect. The natural allicin tablet was administered to the patient.
Several days later, the inflammation disappeared.
[0049] 9. Two patients suffering from stomach disease was
administered with the allicin tablet of the invention. Several days
later, the disease was allievated.
[0050] 10. A diarrhea patient was administered with the allicin
tablet of the invention. Several times later, the diarrhea
disappeared.
[0051] 11. Seven patients suffering from toothache which resulted
in headache was administered with the allicin tablet of the
invention. Several times later, the aches disappeared.
[0052] 12. Two patients suffering from urinary tract infection were
administered with the allicin tablet of the invention. Three times
later, the disease disappeared.
[0053] 13. Two patients having nasal obstruction were administered
with the allicin tablet of the invention. Three times later, the
disease disappeared.
[0054] 14. A patient suffering from prostatitis was administered
with the allicin tablet of the invention. One week later, the
disease weakened.
[0055] 15. A patient suffering from an inflamed and aching tonsil
with fever was administered with the allicin tablet of the
invention. Half an hour later, the disease weakened. Four hours
later, the allicin tablet was administered again. Soon, the fever
and inflammation disappeared.
[0056] 16. A patient suffering from high fever was administered
with the allicin tablet of the invention thrice within 15 hrs.
Gradually, the fever disappeared.
[0057] 17. Two girls suffered from high fever, oral and hand ulcer.
They cried all the time and had no appetite. The allicin tablet of
the invention was administered. After an hour, the girls calmed
down and had appetite. In the following two days, some medicine and
the tablet were administered and all the symptoms disappeared
soon.
[0058] These clinical cases show that the allicin tablet has
capability of anti-bacteria and anti-inflammation. However, in use,
the dosage should be large. In contrast to the allicin tablets in
the prior art, the tablet has the characteristic of the highest
allicin content per piece, the largest dosage administered safely
and no side effects.
[0059] While particular embodiments of the invention have been
shown and described, it will be obvious to those skilled in the art
that changes and modifications may be made without departing from
the invention in its broader aspects, and therefore, the aim in the
appended claims is to cover all such changes and modifications as
fall within the true spirit and scope of the invention.
* * * * *