U.S. patent application number 13/003740 was filed with the patent office on 2011-07-28 for compositions and methods for inhibiting expression of gsk-3 genes.
Invention is credited to Gregory Hinkle, Dinah Sah, Dinah Wen-Yee Sah.
Application Number | 20110184046 13/003740 |
Document ID | / |
Family ID | 41320249 |
Filed Date | 2011-07-28 |
United States Patent
Application |
20110184046 |
Kind Code |
A1 |
Sah; Dinah Wen-Yee ; et
al. |
July 28, 2011 |
Compositions And Methods For Inhibiting Expression Of GSK-3
Genes
Abstract
The invention relates to a double-stranded ribonucleic acid
(dsRNA) targeting Glycogen Synthase Kinase-3 (GSK-3), and methods
of using the dsRNA to inhibit expression of GSK-3.
Inventors: |
Sah; Dinah Wen-Yee; (Boston,
MA) ; Sah; Dinah; (Boston, MA) ; Hinkle;
Gregory; (Plymouth, MA) |
Family ID: |
41320249 |
Appl. No.: |
13/003740 |
Filed: |
July 13, 2009 |
PCT Filed: |
July 13, 2009 |
PCT NO: |
PCT/US09/50432 |
371 Date: |
April 7, 2011 |
Current U.S.
Class: |
514/44A ;
435/320.1; 435/325; 435/375; 536/24.5 |
Current CPC
Class: |
A61P 25/24 20180101;
C12N 15/1137 20130101; C12N 2310/321 20130101; C12N 2320/30
20130101; A61P 3/00 20180101; A61P 7/00 20180101; A61P 33/02
20180101; A61P 35/00 20180101; A61P 25/00 20180101; C12N 15/113
20130101; C12N 2310/11 20130101; A61P 25/28 20180101; A61P 25/18
20180101; C12N 2310/14 20130101; A61P 21/00 20180101; A61P 3/10
20180101; A61P 25/16 20180101; C12Y 207/11026 20130101; A61P 29/00
20180101; C12N 2310/321 20130101; C12N 2310/3521 20130101 |
Class at
Publication: |
514/44.A ;
536/24.5; 435/320.1; 435/375; 435/325 |
International
Class: |
A61K 31/713 20060101
A61K031/713; C07H 21/02 20060101 C07H021/02; C12N 15/63 20060101
C12N015/63; C12N 5/071 20100101 C12N005/071; A61P 3/00 20060101
A61P003/00; A61P 3/10 20060101 A61P003/10; A61P 25/00 20060101
A61P025/00; A61P 25/28 20060101 A61P025/28; A61P 25/16 20060101
A61P025/16; A61P 25/18 20060101 A61P025/18; A61P 25/24 20060101
A61P025/24; A61P 35/00 20060101 A61P035/00; A61P 33/02 20060101
A61P033/02; A61P 29/00 20060101 A61P029/00; A61P 21/00 20060101
A61P021/00; A61P 7/00 20060101 A61P007/00; C12N 5/10 20060101
C12N005/10 |
Foreign Application Data
Date |
Code |
Application Number |
Jul 11, 2008 |
US |
61080153 |
Claims
1. A double-stranded ribonucleic acid (dsRNA), comprising a sense
strand and an antisense strand, the sense strand comprising a first
sequence and the antisense strand comprising a second sequence, the
second sequence comprising a region complementary to an mRNA
encoding a GSK-3, and wherein said region of complementarity is
less than 30 nucleotides in length.
2. (canceled)
3. The dsRNA of claim 1, the second sequence comprising a region
complementary to at least 15 nucleotides of the sense strand of
huGSKA-3 (SEQ ID NO:13075).
4. The dsRNA of claim 1, the second sequence comprising a region
complementary to the sense strand of huGSKA-3 (SEQ ID
NO:13075).
5. The dsRNA of claim 1, the antisense strand comprising at least
15 nucleotides of the antisense strand of huGSKA-3 (SEQ ID
NO:13083).
6. The dsRNA of claim 1, the antisense strand comprising the
antisense strand of huGSKA-3 (SEQ ID NO:13083).
7. The dsRNA of claim 1, the antisense strand consisting of the
antisense strand of huGSKA-3 (SEQ ID NO:13083).
8. The dsRNA of claim 1, the sense strand comprising at least 15
nucleotides of the sense strand of huGSKA-3 (SEQ ID NO:13075).
9. The dsRNA of claim 1, the sense strand comprising the sense
strand of huGSKA-3 (SEQ ID NO:13075).
10. The dsRNA of claim 1, the sense strand consisting of the sense
strand of huGSKA-3 (SEQ ID NO:13075).
11. The dsRNA of claim 1, the sense strand consisting of the sense
strand of huGSKA-3 (SEQ ID NO:13075) and the antisense strand
consisting of the antisense strand of huGSKA-3 (SEQ ID
NO:13083).
12. (canceled)
13. (canceled)
14. (canceled)
15. (canceled)
16. The dsRNA of claim 1, wherein said dsRNA comprises at least one
modified nucleotide.
17. The dsRNA of claim 16, wherein at least one of said modified
nucleotides is chosen from the group of: a 2'-O-methyl modified
nucleotide, a nucleotide comprising a 5'-phosphorothioate group,
and a terminal nucleotide linked to a cholesteryl derivative or
dodecanoic acid bisdecylamide group.
18. The dsRNA of claim 16, wherein said modified nucleotide is
chosen from the group of: a 2'-deoxy-2'-fluoro modified nucleotide,
a 2'-deoxy-modified nucleotide, a locked nucleotide, an abasic
nucleotide, 2'-amino-modified nucleotide, 2'-alkyl-modified
nucleotide, morpholino nucleotide, a phosphoramidate, and a
non-natural base comprising nucleotide.
19. The dsRNA of claim 16, comprising at least one 2'-O-methyl
modified nucleotide and at least one nucleotide comprising a
5'-phosphorothioate group,
20. The dsRNA of claim 1, wherein the region of complementary is at
least 15 nucleotides in length.
21. The dsRNA of claim 1, wherein the region of complementarity is
between 19 and 21 nucleotides in length.
22. The dsRNA of claim 1, wherein the region of complementarity is
19 nucleotides in length.
23. The dsRNA of claim 1, wherein administration of the dsRNA
inhibits expression of GSK3 by more than 40%.
24. The dsRNA of claim 1, wherein the dsRNA exhibits an 1050 of
less than or equal to 10 nM in suppressing GSK3.
25. The dsRNA of claim 1, wherein the dsRNA exhibits an 1050 of
less than or equal to 1.0 nM in suppressing GSK3.
26. A cell comprising the dsRNA of claim 1.
27. A vector comprising at least one strand of the dsRNA of claim
1.
28. A cell comprising the vector of claim 27.
29. A pharmaceutical composition for inhibiting expression of an
GSK-3 gene comprising the dsRNA of claim 1.
30. A method of inhibiting GSK-3 expression in a cell, the method
comprising: (a) introducing into the cell the dsRNA of claim 1; and
(b) maintaining the cell produced in step (a) for a time sufficient
to obtain degradation of the mRNA transcript of a GSK-3 gene,
thereby inhibiting expression of a GSK-3 gene in the cell.
31. A method of treating a disorder mediated by GSK-3 expression
comprising administering to a human in need of such treatment a
therapeutically effective amount of the dsRNA of claim 1.
32. (canceled)
Description
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of U.S. Provisional
Application No. 61/080,153, filed Jul. 11, 2008, which is hereby
incorporated in its entirety by reference.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
[0002] None.
FIELD OF THE INVENTION
[0003] The invention relates to a double-stranded ribonucleic acid
(dsRNA) targeting Glycogen Synthase Kinase-3 alpha and/or beta
(GSK-3 alpha and/or beta), and methods of using the dsRNA to
inhibit expression of GSK-3. alpha and/or beta.
BACKGROUND OF THE INVENTION
[0004] Glycogen synthase kinase-3 (GSK-3) is a multifunctional
serine/threonine kinase. It functions as a key regulator of
numerous signaling pathways. It phosphorylates and inactivates
glycogen synthase, a key enzyme in glycogen metabolism. It has also
been shown to be involved in the regulation of a diverse array of
cellular functions, including protein synthesis, cell
proliferation, cell differentiation, microtubule
assembly/disassembly, and apoptosis. Two isoforms of GSK-3 have
been reported in mammals: an approximately 51 kDa GSK-3 alpha form
and an approximately 47 kDa GSK-3 beta form. These two isoforms
exhibit about 98% homology in their kinase domains. Other regions
share less homology: they share only about 36% identity in the last
76 C-terminal amino acid residues.
[0005] Double-stranded RNA molecules (dsRNA) have been shown to
block gene expression in a highly conserved regulatory mechanism
known as RNA interference (RNAi). WO 99/32619 (Fire et al.)
disclosed the use of a dsRNA of at least 25 nucleotides in length
to inhibit the expression of genes in C. elegans. dsRNA has also
been shown to degrade target RNA in other organisms, including
plants (see, e.g., WO 99/53050, Waterhouse et al.; and WO 99/61631,
Heifetz et al.), Drosophila (see, e.g., Yang, D., et al., Curr.
Biol. (2000) 10:1191-1200), and mammals (see WO 00/44895, Limmer;
and DE 101 00 586.5, Kreutzer et al.).
SUMMARY OF THE INVENTION
[0006] The invention provides compositions containing
double-stranded ribonucleic acid (dsRNA) targeted to a GSK-3 gene
and methods for inhibiting the expression of a GSK-3 gene in a cell
or mammal. The composition can inhibit GSK-3 alpha and/or GSK-3
beta. A composition that inhibits both can do so, e.g., by
including a dsRNA that targets both GSK-3 alpha and GSK-3 beta, or
by including a first dsRNA that inhibits GSK-3 alpha and a second
dsRNA that inhibits GSK-3 beta. The composition can also include a
dsRNA which inhibits both and a second which inhibits only one of
the isoforms.
[0007] The invention also provides compositions and methods for
treating manic depression (bipolar disorder).
[0008] Other disorders, e.g., pathological conditions and diseases
caused by the expression of a GSK-3 gene, such as metabolic
disorders (e.g., Type I or Type II diabetes or metabolic syndrome)
and nervous system disorders, (e.g., CNS and nuerogenerative
disorders (e.g., Alzheimer's disease, Parkinson's disease,
Huntington's Disease, bipolar disorder, prion diseases (e.g.,
transmissible spongiform encephalopathies), stroke and
schizophrenia). Compositions and methods for treating pathological
conditions and diseases such as protozoan diseases (e.g.,
Plasmodium falciparum), cancer (e.g., colorectal cancer), and
circadian rhythm diseases (e.g., sleep disorders, jet lag, and
shift work), are also provided. The dsRNAs described herein can
also be used to regulate skeletal muscle growth, inflammatory
responses, platelet function, apoptosis, and cellular responses to
DNA damage.
[0009] In one embodiment the invention provides a double-stranded
ribonucleic acid (dsRNA), having a sense strand and an antisense
strand, the sense strand comprising a first sequence and the
antisense strand comprising a second sequence, the second sequence
comprising a region complementary to an mRNA encoding a GSK-3 gene,
and wherein said region of complementarity is less than 30
nucleotides in length. In some embodiments, the second sequence
includes a region complementary to the GSK-3 gene sequences
NM.sub.--019884, NM.sub.--00103166, :NM.sub.--002093, or
NM.sub.--019827. In other embodiments, the second sequence includes
a region complementary to at least 15 nucleotides of a target
sequence described herein, e.g., in Table 1 or Table 2 or Table 4
or Table 5 or Table 6 or Table 7. The second sequence can include a
region complementary to a target sequence described in Table 1 or
Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
[0010] The antisense strand of the dsRNA of the invention can
include at least 15 nucleotides of one of the antisense strand
sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or
Table 7. In one embodiment, the antisense strand includes one of
the antisense strand sequences in Table 1 or Table 2 or Table 4 or
Table 5 or Table 6 or Table 7. In another embodiment, the antisense
strand consists of one of the antisense strand sequences in Table 1
or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
[0011] The sense strand can include at least 15 nucleotides of one
of the sense strand sequences in Table 1 or Table 2 or Table 4 or
Table 5 or Table 6 or Table 7. For example, the sense strand can
include or can consist of one of the sense strand sequences in
Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
[0012] In some embodiments, the dsRNA of the invention consists of
one of the sense strand sequences in Table 1 or Table 2 or Table 4
or Table 5 or Table 6 or Table 7 and the antisense strand consists
of one of the antisense strand sequences in Table 1 or Table 2 or
Table 4 or Table 5 or Table 6 or Table 7. Further embodiments
include the duplexes disclosed herein, e.g., huGSKA-3, huGSKB-11,
AD-18821, AD-18825, AD-18826, AD-18838, AD-18843, or AD-18844.
[0013] The dsRNA of the invention can include at least one modified
nucleotide. Disclosed herein are exemplary modified sequences, but
one of skill can readily design duplexes with different set of
modifications using the sequences and teachings herein. The
modified nucleotides can be, e.g., a 2'-O-methyl modified
nucleotide, a nucleotide comprising a 5'-phosphorothioate group, or
a terminal nucleotide linked to a cholesteryl derivative or
dodecanoic acid bisdecylamide group. The modified nucleotide(s) can
be a 2'-deoxy-2'-fluoro modified nucleotide, a 2'-deoxy-modified
nucleotide, a locked nucleotide, an abasic nucleotide,
2'-amino-modified nucleotide, 2'-alkyl-modified nucleotide,
morpholino nucleotide, a phosphoramidate, and a non-natural base
comprising nucleotide. In one embodiment the dsRNA of the invention
includes at least one 2'-O-methyl modified nucleotide and at least
one nucleotide comprising a 5'-phosphorothioate group.
[0014] The region of complementarity of the dsRNA of the invention
is less than 30 nucleotides, e.g., at least 15 nucleotides in
length, or, e.g., between 19 and 21 nucleotides in length, or,
e.g., 19 nucleotides in length.
[0015] Disclosed and claimed herein are methods for inhibiting
expression of a GSK-3 gene. In one embodiment, administration of
the dsRNA inhibits expression of GSK3 by more than 40%. In another
embodiment the dsRNA exhibits an IC50 of less than or equal to 10
nM in suppressing GSK3. Alternatively, the dsRNA exhibits an IC50
of less than or equal to 1.0 nM in suppressing GSK3.
[0016] Also included in the invention are cells and vectors
comprising the dsRNA of the invention.
[0017] Further contemplated is a pharmaceutical composition for
inhibiting expression of an GSK-3 gene comprising a dsRNA of the
invention.
[0018] Methods of inhibiting GSK-3 expression in a cell are
included in the invention. The methods include (a) introducing into
the cell the dsRNA of the invention; and (b) maintaining the cell
produced in step (a) for a time sufficient to obtain degradation of
the mRNA transcript of a GSK-3 gene, thereby inhibiting expression
of a GSK-3 gene in the cell.
[0019] Also included is a method of treating a disorder mediated by
GSK-3 expression comprising administering to a human in need of
such treatment a therapeutically effective amount of a dsRNA of the
invention, including treatment of manic depression.
BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS
[0020] These and other features, aspects, and advantages of the
present invention will become better understood with regard to the
following description, and accompanying drawings, where:
[0021] FIG. 1 is a graph illustrating the results of GSK3.alpha.
mRNA suppression in HT22 cells 24 hours after 37.5 nM siRNA
transfection.
[0022] FIG. 2 is a graph illustrating the results of GSK3.beta.
mRNA suppression in HT22 cells 24 hours after 37.5 nM siRNA
transfection.
[0023] FIG. 3 is a graph illustrating the dose dependence of
GSK3.alpha. mRNA suppression after siRNA transfection of HT22
cells.
[0024] FIG. 4 is a graph illustrating the dose dependence of GSK3
.beta. mRNA suppression after siRNA transfection of HT22 cells.
[0025] FIG. 5 is a western blot illustrating protein levels after
siRNA transfection in HT22 cells.
[0026] FIG. 6 is a graph illustrating GSK3.beta. mRNA suppression
in mouse nucleus accumbens after 14 day infusion of AD-18844 into
the nucleus accumbens.
[0027] FIG. 7 is a graph illustrating GSK3.alpha. mRNA suppression
in mouse nucleus accumbens after 14 day infusion of AD-18826 into
the nucleus accumbens.
DETAILED DESCRIPTION OF THE INVENTION
[0028] The invention provides dsRNAs and methods of using the
dsRNAs for inhibiting the expression of a GSK-3 gene in a cell or a
mammal where the dsRNA targets a GSK-3 gene. The invention also
provides compositions and methods for treating pathological
conditions and diseases, such as a metabolic disease or a
cardiovascular disease, in a mammal caused by the expression of a
GSK-3 gene. dsRNA directs the sequence-specific degradation of mRNA
through a process known as RNA interference (RNAi).
[0029] The dsRNAs of the compositions featured herein include an
RNA strand (the antisense strand) having a region which is less
than 30 nucleotides in length, generally 19-24 nucleotides in
length, and is substantially complementary to at least part of an
mRNA transcript of a GSK-3 gene. The use of these dsRNAs enables
the targeted degradation of mRNAs of genes that are implicated in
replication and or maintenance of cancer cells in mammals. Very low
dosages of GSK-3 dsRNAs in particular can specifically and
efficiently mediate RNAi, resulting in significant inhibition of
expression of the GSK-3 gene. The methods and compositions of the
invention containing the GSK-3 dsRNA are useful for treating
pathological processes mediated by GSK-3 expression, e.g., manic
depression, or other disorders described herein.
[0030] The following detailed description discloses how to make and
use the compositions containing dsRNAs to inhibit the expression of
a GSK-3 gene, as well as compositions and methods for treating
diseases and disorders caused by the expression of these genes,
such as manic depression. The pharmaceutical compositions featured
in the invention include a dsRNA having an antisense strand
comprising a region of complementarity which is less than 30
nucleotides in length, generally 19-24 nucleotides in length, and
is substantially complementary to at least part of an RNA
transcript of a GSK-3 gene, together with a pharmaceutically
acceptable carrier. The compositions featured in the invention also
include a dsRNA having an antisense strand having a region of
complementarity which is less than 30 nucleotides in length,
generally 19-24 nucleotides in length, and is substantially
complementary to at least part of an RNA transcript of a GSK-3
gene.
[0031] Accordingly, certain aspects of the invention provide
pharmaceutical compositions containing the GSK-3 dsRNA and a
pharmaceutically acceptable carrier, methods of using the
compositions to inhibit expression of a GSK-3 gene, and methods of
using the pharmaceutical compositions to treat diseases caused by
expression of the GSK-3 gene.
I. DEFINITIONS
[0032] For convenience, the meaning of certain terms and phrases
used in the specification, examples, and appended claims, are
provided below. If there is an apparent discrepancy between the
usage of a term in other parts of this specification and its
definition provided in this section, the definition in this section
shall prevail.
[0033] "G," "C," "A" and "U" each generally stand for a nucleotide
that contains guanine, cytosine, adenine, and uracil as a base,
respectively. "T" and "dT" are used interchangeably herein and
refer to a deoxyribonucleotide wherein the nucleobase is thymine,
e.g., deoxyribothymine. However, it will be understood that the
term "ribonucleotide" or "nucleotide" or "deoxyribonucleotide" can
also refer to a modified nucleotide, as further detailed below, or
a surrogate replacement moiety. The skilled person is well aware
that guanine, cytosine, adenine, and uracil may be replaced by
other moieties without substantially altering the base pairing
properties of an oligonucleotide comprising a nucleotide bearing
such replacement moiety. For example, without limitation, a
nucleotide comprising inosine as its base may base pair with
nucleotides containing adenine, cytosine, or uracil. Hence,
nucleotides containing uracil, guanine, or adenine may be replaced
in the nucleotide sequences of the invention by a nucleotide
containing, for example, inosine. Sequences comprising such
replacement moieties are embodiments of the invention.
[0034] As used herein, "GSK-3" refers to Glycogen Synthase
Kinase-3, which is also known as DKFZp686D0638, GSK3, C86142,
GSK-3beta, 7330414F15Rik, and 8430431H08Rik. GSK-3 alpha sequence
can be found as NCBI GeneID:2931 (human) and 606496 (mouse) and
RefSeq ID number:NM.sub.--019884 (human) and NM.sub.--001031667
(mouse). GSK-3 beta sequence can be found as NCBI GeneID:2932
(human) and 56637 (mouse) and RefSeq ID number:NM.sub.--002093
(human) and NM.sub.--019827 (mouse). A dsRNA featured in the
invention can target a specific GSK-3 isoform, e.g. GSK-3 alpha or
GSK-3 beta, or a dsRNA of the invention can target both isoforms by
binding to a common region of the mRNA transcript. A dsRNA featured
in the invention can target a specific GSK-3 beta isoform, e.g.
GSK-3 beta 1 or GSK-3 beta 2, or a dsRNA of the invention can
target both isoforms by binding to a common region of the mRNA
transcript.
[0035] As used herein, "target sequence" refers to a contiguous
portion of the nucleotide sequence of an mRNA molecule formed
during the transcription of a GSK-3 gene, including mRNA that is a
product of RNA processing of a primary transcription product.
[0036] As used herein, the term "strand comprising a sequence"
refers to an oligonucleotide comprising a chain of nucleotides that
is described by the sequence referred to using the standard
nucleotide nomenclature.
[0037] As used herein, and unless otherwise indicated, the term
"complementary," when used to describe a first nucleotide sequence
in relation to a second nucleotide sequence, refers to the ability
of an oligonucleotide or polynucleotide comprising the first
nucleotide sequence to hybridize and form a duplex structure under
certain conditions with an oligonucleotide or polynucleotide
comprising the second nucleotide sequence, as will be understood by
the skilled person. Such conditions can, for example, be stringent
conditions, where stringent conditions may include: 400 mM NaCl, 40
mM PIPES pH 6.4, 1 mM EDTA, 50.degree. C. or 70.degree. C. for
12-16 hours followed by washing. Other conditions, such as
physiologically relevant conditions as may be encountered inside an
organism, can apply. The skilled person will be able to determine
the set of conditions most appropriate for a test of
complementarity of two sequences in accordance with the ultimate
application of the hybridized nucleotides.
[0038] This includes base-pairing of the oligonucleotide or
polynucleotide comprising the first nucleotide sequence to the
oligonucleotide or polynucleotide comprising the second nucleotide
sequence over the entire length of the first and second nucleotide
sequence. Such sequences can be referred to as "fully
complementary" with respect to each other herein. However, where a
first sequence is referred to as "substantially complementary" with
respect to a second sequence herein, the two sequences can be fully
complementary, or they may form one or more, but generally not more
than 4, 3 or 2 mismatched base pairs upon hybridization, while
retaining the ability to hybridize under the conditions most
relevant to their ultimate application. However, where two
oligonucleotides are designed to form, upon hybridization, one or
more single stranded overhangs, such overhangs shall not be
regarded as mismatches with regard to the determination of
complementarity. For example, a dsRNA comprising one
oligonucleotide 21 nucleotides in length and another
oligonucleotide 23 nucleotides in length, wherein the longer
oligonucleotide comprises a sequence of 21 nucleotides that is
fully complementary to the shorter oligonucleotide, may yet be
referred to as "fully complementary" for the purposes of the
invention.
[0039] "Complementary" sequences, as used herein, may also include,
or be formed entirely from, non-Watson-Crick base pairs and/or base
pairs formed from non-natural and modified nucleotides, in as far
as the above requirements with respect to their ability to
hybridize are fulfilled. Such non-Watson-Crick base pairs includes,
but not limited to, G:U Wobble or Hoogstein base pairing.
[0040] The terms "complementary", "fully complementary" and
"substantially complementary" herein may be used with respect to
the base matching between the sense strand and the antisense strand
of a dsRNA, or between the antisense strand of a dsRNA and a target
sequence, as will be understood from the context of their use.
[0041] As used herein, a polynucleotide which is "substantially
complementary to at least part of" a messenger RNA (mRNA) refers to
a polynucleotide which is substantially complementary to a
contiguous portion of the mRNA of interest (e.g., encoding a GSK-3)
including a 5' UTR, an open reading frame (ORF), or a 3' UTR. For
example, a polynucleotide is complementary to at least a part of a
GSK-3 mRNA if the sequence is substantially complementary to a
non-interrupted portion of an mRNA encoding a GSK-3.
[0042] The term "double-stranded RNA" or "dsRNA", as used herein,
refers to a complex of ribonucleic acid molecules, having a duplex
structure comprising two anti-parallel and substantially
complementary, as defined above, nucleic acid strands. In general,
the majority of nucleotides of each strand are ribonucleotides, but
as described in detail herein, each or both strands can also
include at least one non-ribonucleotide, e.g., a
deoxyribonucleotide and/or a modified nucleotide. In addition, as
used in this specification, "dsRNA" may include chemical
modifications to ribonucleotides, including substantial
modifications at multiple nucleotides and including all types of
modifications disclosed herein or known in the art. Any such
modifications, as used in an siRNA type molecule, are encompassed
by "dsRNA" for the purposes of this specification and claims. The
two strands forming the duplex structure may be different portions
of one larger RNA molecule, or they may be separate RNA molecules.
Where the two strands are part of one larger molecule, and
therefore are connected by an uninterrupted chain of nucleotides
between the 3'-end of one strand and the 5' end of the respective
other strand forming the duplex structure, the connecting RNA chain
is referred to as a "hairpin loop". Where the two strands are
connected covalently by means other than an uninterrupted chain of
nucleotides between the 3'-end of one strand and the 5' end of the
respective other strand forming the duplex structure, the
connecting structure is referred to as a "linker". The RNA strands
may have the same or a different number of nucleotides. The maximum
number of base pairs is the number of nucleotides in the shortest
strand of the dsRNA minus any overhangs that are present in the
duplex. In addition to the duplex structure, a dsRNA may comprise
one or more nucleotide overhangs.
[0043] As used herein, a "nucleotide overhang" refers to the
unpaired nucleotide or nucleotides that protrude from the duplex
structure of a dsRNA when a 3'-end of one strand of the dsRNA
extends beyond the 5'-end of the other strand, or vice versa.
"Blunt" or "blunt end" means that there are no unpaired nucleotides
at that end of the dsRNA, i.e., no nucleotide overhang. A "blunt
ended" dsRNA is a dsRNA that is double-stranded over its entire
length, i.e., no nucleotide overhang at either end of the
molecule.
[0044] The term "antisense strand" refers to the strand of a dsRNA
which includes a region that is substantially complementary to a
target sequence. As used herein, the term "region of
complementarity" refers to the region on the antisense strand that
is substantially complementary to a sequence, for example a target
sequence, as defined herein. Where the region of complementarity is
not fully complementary to the target sequence, the mismatches are
most tolerated in the terminal regions and, if present, are
generally in a terminal region or regions, e.g., within 6, 5, 4, 3,
or 2 nucleotides of the 5' and/or 3' terminus.
[0045] The term "sense strand," as used herein, refers to the
strand of a dsRNA that includes a region that is substantially
complementary to a region of the antisense strand.
[0046] "Introducing into a cell", when referring to a dsRNA, means
facilitating uptake or absorption into the cell, as is understood
by those skilled in the art. Absorption or uptake of dsRNA can
occur through unaided diffusive or active cellular processes, or by
auxiliary agents or devices. The meaning of this term is not
limited to cells in vitro; a dsRNA may also be "introduced into a
cell", wherein the cell is part of a living organism. In such
instance, introduction into the cell will include the delivery to
the organism. For example, for in vivo delivery, dsRNA can be
injected into a tissue site or administered systemically. In vitro
introduction into a cell includes methods known in the art such as
electroporation and lipofection.
[0047] The terms "silence" and "inhibit the expression of"
"down-regulate the expression of," "suppress the expression of" and
the like in as far as they refer to a GSK-3 gene, herein refer to
the at least partial suppression of the expression of a GSK-3 gene,
as manifested by a reduction of the amount of mRNA which may be
isolated from a first cell or group of cells in which a GSK-3 gene
is transcribed and which has or have been treated such that the
expression of a GSK-3 gene is inhibited, as compared to a second
cell or group of cells substantially identical to the first cell or
group of cells but which has or have not been so treated (control
cells). The degree of inhibition is usually expressed in terms
of
( mRNA in control cells ) - ( mRNA in treated cells ) ( mRNA in
control cells ) 100 % ##EQU00001##
[0048] Alternatively, the degree of inhibition may be given in
terms of a reduction of a parameter that is functionally linked to
GSK-3 gene transcription, e.g., the amount of protein encoded by a
GSK-3 gene which is secreted by a cell, or the number of cells
displaying a certain phenotype, e.g., apoptosis. In principle,
GSK-3 gene silencing may be determined in any cell expressing the
target, either constitutively or by genomic engineering, and by any
appropriate assay. However, when a reference is needed in order to
determine whether a given dsRNA inhibits the expression of the
GSK-3 gene by a certain degree and therefore is encompassed by the
instant invention, the assay provided in the Examples below shall
serve as such reference.
[0049] For example, in certain instances, expression of a GSK-3
gene is suppressed by at least about 5%, 10%, 15%, 20%, 25%, 30%,
35%, 40%, 45%, or 50% by administration of the double-stranded
oligonucleotide of the invention. In some embodiments, a GSK-3 gene
is suppressed by at least about 60%, 70%, or 80% by administration
of the double-stranded oligonucleotide of the invention. In some
embodiments, a GSK-3 gene is suppressed by at least about 85%, 90%,
or 95% by administration of the double-stranded oligonucleotide of
the invention.
[0050] As used herein in the context of GSK-3 expression, the terms
"treat", "treatment", and the like, refer to relief from or
alleviation of pathological processes mediated by GSK-3 expression.
In the context of the present invention insofar as it relates to
any of the other conditions recited herein below (other than
pathological processes mediated by GSK-3 expression), the terms
"treat", "treatment", and the like mean to relieve or alleviate at
least one symptom associated with such condition, or to slow or
reverse the progression of such condition, such as the slowing and
progression of manic depression.
[0051] As used herein, the phrases "therapeutically effective
amount" and "prophylactically effective amount" refer to an amount
that provides a therapeutic benefit in the treatment, prevention,
or management of pathological processes mediated by GSK-3
expression or an overt symptom of pathological processes mediated
by GSK-3 expression. The specific amount that is therapeutically
effective can be readily determined by ordinary medical
practitioner, and may vary depending on factors known in the art,
such as, e.g. the type of pathological processes mediated by GSK-3
expression, the patient's history and age, the stage of
pathological processes mediated by GSK-3 expression, and the
administration of other anti-pathological processes mediated by
GSK-3 expression agents.
[0052] As used herein, a "pharmaceutical composition" comprises a
pharmacologically effective amount of a dsRNA and a
pharmaceutically acceptable carrier. As used herein,
"pharmacologically effective amount," "therapeutically effective
amount" or simply "effective amount" refers to that amount of an
RNA effective to produce the intended pharmacological, therapeutic
or preventive result. For example, if a given clinical treatment is
considered effective when there is at least a 25% reduction in a
measurable parameter associated with a disease or disorder, a
therapeutically effective amount of a drug for the treatment of
that disease or disorder is the amount necessary to effect at least
a 25% reduction in that parameter.
[0053] The term "pharmaceutically acceptable carrier" refers to a
carrier for administration of a therapeutic agent. Such carriers
include, but are not limited to, saline, buffered saline, dextrose,
water, glycerol, ethanol, and combinations thereof. The term
specifically excludes cell culture medium. For drugs administered
orally, pharmaceutically acceptable carriers include, but are not
limited to pharmaceutically acceptable excipients such as inert
diluents, disintegrating agents, binding agents, lubricating
agents, sweetening agents, flavoring agents, coloring agents and
preservatives. Suitable inert diluents include sodium and calcium
carbonate, sodium and calcium phosphate, and lactose, while corn
starch and alginic acid are suitable disintegrating agents. Binding
agents may include starch and gelatin, while the lubricating agent,
if present, will generally be magnesium stearate, stearic acid or
talc. If desired, the tablets may be coated with a material such as
glyceryl monostearate or glyceryl distearate, to delay absorption
in the gastrointestinal tract.
[0054] As used herein, a "transformed cell" is a cell into which a
vector has been introduced from which a dsRNA molecule may be
expressed.
II. DOUBLE-STRANDED RIBONUCLEIC ACID (dsRNA)
[0055] As described in more detail herein, the invention provides
double-stranded ribonucleic acid (dsRNA) molecules for inhibiting
the expression of a GSK-3 gene in a cell or mammal, e.g., in a
human having manic depression, or another disorder described
herein, where the dsRNA includes an antisense strand having a
region of complementarity which is complementary to at least a part
of an mRNA formed in the expression of a GSK-3 gene, and where the
region of complementarity is less than 30 nucleotides in length,
and where said dsRNA, upon contact with a cell expressing a GSK-3
gene, inhibits the expression of a GSK-3 gene, e.g., by at least
30% as assayed by, for example, a PCR or branched DNA (bDNA) based
method. The dsRNA of the invention may further include one or more
single-stranded nucleotide overhangs.
[0056] The dsRNA can be synthesized by standard methods known in
the art as further discussed below, e.g., by use of an automated
DNA synthesizer, such as are commercially available from, for
example, Biosearch, Applied Biosystems, Inc.
[0057] The dsRNA includes two RNA strands that are sufficiently
complementary to hybridize to form a duplex structure. One strand
of the dsRNA (the antisense strand) includes a region of
complementarity that is substantially complementary, and generally
fully complementary, to a target sequence, derived from the
sequence of an mRNA formed during the expression of the GSK-3 gene,
the other strand (the sense strand) includes a region that is
complementary to the antisense strand, such that the two strands
hybridize and form a duplex structure when combined under suitable
conditions. Generally, the duplex structure is between 15 and 30,
or between 25 and 30, or between 18 and 25, or between 19 and 24,
or between 19 and 21, or 19, 20, or 21 base pairs in length. In one
embodiment the duplex is 19 base pairs in length. In another
embodiment the duplex is 21 base pairs in length. When two
different siRNAs are used in combination, the duplex lengths can be
identical or can differ.
[0058] Similarly, the region of complementarity to the target
sequence can be between 15 and 30, or between 25 and 30, or between
18 and 25, or between 19 and 24, or between 19 and 21, or 19, 20,
or 21 base pairs in length. In one embodiment the region of
complementarity is 19 nucleotides in length. In another embodiment
the region of complementarity is 21 nucleotides in length. When two
different siRNAs are used in combination, the region of
complementarity can be identical or can differ.
[0059] Each strand of the dsRNA of invention is generally between
15 and 30, or between 18 and 25, or 18, 19, 20, 21, 22, 23, 24, or
25 nucleotides in length. In other embodiments, each is strand is
25-30 nucleotides in length. Each strand of the duplex can be the
same length or of different lengths. When two different siRNAs are
used in combination, the lengths of each strand of each siRNA can
be identical or can differ.
[0060] The dsRNA of the invention can include one or more
single-stranded overhang(s) of one or more nucleotides. In one
embodiment, at least one end of the dsRNA has a single-stranded
nucleotide overhang of 1 to 4, generally 1 or 2 nucleotides. In
another embodiment, the antisense strand of the dsRNA has 1-10
nucleotides overhangs each at the 3' end and the 5' end over the
sense strand. In further embodiments, the sense strand of the dsRNA
has 1-10 nucleotides overhangs each at the 3' end and the 5' end
over the antisense strand.
[0061] A dsRNAs having at least one nucleotide overhang can have
unexpectedly superior inhibitory properties than the blunt-ended
counterpart. In some embodiments the presence of only one
nucleotide overhang strengthens the interference activity of the
dsRNA, without affecting its overall stability. A dsRNA having only
one overhang has proven particularly stable and effective in vivo,
as well as in a variety of cells, cell culture mediums, blood, and
serum. Generally, the single-stranded overhang is located at the
3'-terminal end of the antisense strand or, alternatively, at the
3'-terminal end of the sense strand. The dsRNA can also have a
blunt end, generally located at the 5'-end of the antisense strand.
Such dsRNAs can have improved stability and inhibitory activity,
thus allowing administration at low dosages, i.e., less than 5
mg/kg body weight of the recipient per day. Generally, the
antisense strand of the dsRNA has a nucleotide overhang at the
3'-end, and the 5'-end is blunt. In another embodiment, one or more
of the nucleotides in the overhang is replaced with a nucleoside
thiophosphate.
[0062] In one embodiment, the targeted GSK-3 gene is the human
GSK-3 gene. In another embodiment, the targeted GSK-3 gene is a
mouse gene. In some embodiments, the sense strand of the dsRNA
includes a sense sequence from Table 1 or Table 2 or Table 4 or
Table 5 or Table 6 or Table 7, and the antisense sequence includes
an antisense sequence of Table 1 or Table 2 or Table 4 or Table 5
or Table 6 or Table 7. Alternative antisense agents that target
elsewhere in the target sequence provided in Table 1 or Table 2 or
Table 4 or Table 5 or Table 6 or Table 7 can readily be determined
using the target sequence and the flanking GSK-3 sequence.
[0063] The skilled person is well aware that dsRNAs comprising a
duplex structure of between 20 and 23, but specifically 21, base
pairs have been hailed as particularly effective in inducing RNA
interference (Elbashir et al., EMBO 2001, 20:6877-6888). However,
others have found that shorter or longer dsRNAs can be effective as
well. In the embodiments described above, by virtue of the nature
of the oligonucleotide sequences provided in Table 1 or Table 2 or
Table 4 or Table 5 or Table 6 or Table 7, the dsRNAs of the
invention can include at least one strand of a length of minimally
21 nt. It can be reasonably expected that shorter dsRNAs having one
of the sequences of Table 1 or Table 2 or Table 4 or Table 5 or
Table 6 or Table 7 minus only a few nucleotides on one or both ends
may be similarly effective as compared to the dsRNAs described
above. Hence, dsRNAs having a partial sequence of at least 15, 16,
17, 18, 19, 20, or more contiguous nucleotides from one of the
sequences of Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or
Table 7, and differing in their ability to inhibit the expression
of a GSK-3 gene in an assay as described herein below by not more
than 5, 10, 15, 20, 25, or 30% inhibition from a dsRNA comprising
the full sequence, are contemplated by the invention. Further
dsRNAs that cleave within the target sequence provided in Table 1
or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 can readily
be made using the GSK-3 sequence and the target sequence
provided.
[0064] In addition, the siRNA agents provided in Table 1 or Table 2
or Table 4 or Table 5 or Table 6 or Table 7 identify a site in a
GSK-3 mRNA that is susceptible to siRNA based cleavage. As such the
present invention further features siRNA agents that target within
the sequence targeted by one of the agents of the present
invention. As used herein a second siRNA agent is said to target
within the sequence of a first siRNA agent if the second siRNA
agent cleaves the message anywhere within the mRNA that is
complementary to the antisense strand of the first siRNA agent.
Such a second agent will generally consist of at least 15
contiguous nucleotides from one of the sequences provided in Table
1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 coupled to
additional nucleotide sequences taken from the region contiguous to
the selected sequence in the GSK-3 gene. For example, the last 15
nucleotides of SEQ ID NO:1 combined with the next 6 nucleotides
from the target GSK-3 gene produces a single strand agent of 21
nucleotides that is based on one of the sequences provided in Table
1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
[0065] The dsRNA of the invention can contain one or more
mismatches to the target sequence. In a preferred embodiment, the
dsRNA of the invention contains no more than 3 mismatches. If the
antisense strand of the dsRNA contains mismatches to a target
sequence, it is preferable that the area of mismatch not be located
in the center of the region of complementarity. If the antisense
strand of the dsRNA contains mismatches to the target sequence, it
is preferable that the mismatch be restricted to 5 nucleotides from
either end, for example 5, 4, 3, 2, or 1 nucleotide from either the
5' or 3' end of the region of complementarity. For example, for a
23 nucleotide dsRNA strand which is complementary to a region of
the GSK-3 gene, the dsRNA generally does not contain any mismatch
within the central 13 nucleotides. The methods described within the
invention can be used to determine whether a dsRNA containing a
mismatch to a target sequence is effective in inhibiting the
expression of a GSK-3 gene. Consideration of the efficacy of dsRNAs
with mismatches in inhibiting expression of a GSK-3 gene is
important, especially if the particular region of complementarity
in a GSK-3 gene is known to have polymorphic sequence variation
within the population.
[0066] In some embodiments the sense and/or antisense sequences of
the dsRNA molecules featured herein can have the primary sequence
shown in the tables with or without the modifications shown in the
tables. In other embodiments the dsRNA molecule can differ by not
more than 1, 2 or 3 bases from that provided in the tables.
[0067] In one embodiment, at least one end of the dsRNA has a
single-stranded nucleotide overhang of 1 to 4, generally 1 or 2
nucleotides. dsRNAs having at least one nucleotide overhang have
superior inhibitory properties than their blunt-ended counterparts.
The presence of only one nucleotide overhang strengthens the
interference activity of the dsRNA, without affecting its overall
stability. dsRNA having only one overhang has proven particularly
stable and effective in vivo, as well as in a variety of cells,
cell culture mediums, blood, and serum. Generally, the
single-stranded overhang is located at the 3'-terminal end of the
antisense strand or, alternatively, at the 3'-terminal end of the
sense strand. The dsRNA may also have a blunt end, generally
located at the 5'-end of the antisense strand. Such dsRNAs have
improved stability and inhibitory activity, thus allowing
administration at low dosages, i.e., less than 5 mg/kg body weight
of the recipient per day. Generally, the antisense strand of the
dsRNA has a nucleotide overhang at the 3'-end, and the 5'-end is
blunt. In another embodiment, one or more of the nucleotides in the
overhang is replaced with a nucleoside thiophosphate.
[0068] Modifications
[0069] In yet another embodiment, the dsRNA is chemically modified
to enhance stability. The nucleic acids of the invention may be
synthesized and/or modified by methods well established in the art,
such as those described in "Current protocols in nucleic acid
chemistry", Beaucage, S. L. et al. (Edrs.), John Wiley & Sons,
Inc., New York, N.Y., USA, which is hereby incorporated herein by
reference. Specific examples of preferred dsRNA compounds useful in
this invention include dsRNAs containing modified backbones or no
natural internucleoside linkages. As defined in this specification,
dsRNAs having modified backbones include those that retain a
phosphorus atom in the backbone and those that do not have a
phosphorus atom in the backbone. For the purposes of this
specification, and as sometimes referenced in the art, modified
dsRNAs that do not have a phosphorus atom in their internucleoside
backbone can also be considered to be oligonucleosides.
[0070] Preferred modified dsRNA backbones include, for example,
phosphorothioates, chiral phosphorothioates, phosphorodithioates,
phosphotriesters, aminoalkylphosphotriesters, methyl and other
alkyl phosphonates including 3'-alkylene phosphonates and chiral
phosphonates, phosphinates, phosphoramidates including 3'-amino
phosphoramidate and aminoalkylphosphoramidates,
thionophosphoramidates, thionoalkylphosphonates,
thionoalkylphosphotriesters, and boranophosphates having normal
3'-5' linkages, 2'-5' linked analogs of these, and those) having
inverted polarity wherein the adjacent pairs of nucleoside units
are linked 3'-5' to 5'-3' or 2'-5' to 5'-2'. Various salts, mixed
salts and free acid forms are also included.
[0071] Representative U.S. patents that teach the preparation of
the above phosphorus-containing linkages include, but are not
limited to, U.S. Pat. Nos. 3,687,808; 4,469,863; 4,476,301;
5,023,243; 5,177,195; 5,188,897; 5,264,423; 5,276,019; 5,278,302;
5,286,717; 5,321,131; 5,399,676; 5,405,939; 5,453,496; 5,455,233;
5,466,677; 5,476,925; 5,519,126; 5,536,821; 5,541,316; 5,550,111;
5,563,253; 5,571,799; 5,587,361; and 5,625,050, each of which is
herein incorporated by reference
[0072] Preferred modified dsRNA backbones that do not include a
phosphorus atom therein have backbones that are formed by short
chain alkyl or cycloalkyl internucleoside linkages, mixed
heteroatoms and alkyl or cycloalkyl internucleoside linkages, or
one or more short chain heteroatomic or heterocyclic
internucleoside linkages. These include those having morpholino
linkages (formed in part from the sugar portion of a nucleoside);
siloxane backbones; sulfide, sulfoxide and sulfone backbones;
formacetyl and thioformacetyl backbones; methylene formacetyl and
thioformacetyl backbones; alkene containing backbones; sulfamate
backbones; methyleneimino and methylenehydrazino backbones;
sulfonate and sulfonamide backbones; amide backbones; and others
having mixed N, O, S and CH2 component parts.
[0073] Representative U.S. patents that teach the preparation of
the above oligonucleosides include, but are not limited to, U.S.
Pat. Nos. 5,034,506; 5,166,315; 5,185,444; 5,214,134; 5,216,141;
5,235,033; 5,64,562; 5,264,564; 5,405,938; 5,434,257; 5,466,677;
5,470,967; 5,489,677; 5,541,307; 5,561,225; 5,596,086; 5,602,240;
5,608,046; 5,610,289; 5,618,704; 5,623,070; 5,663,312; 5,633,360;
5,677,437; and, 5,677,439, each of which is herein incorporated by
reference.
[0074] In other preferred dsRNA mimetics, both the sugar and the
internucleoside linkage, i.e., the backbone, of the nucleotide
units are replaced with novel groups. The base units are maintained
for hybridization with an appropriate nucleic acid target compound.
One such oligomeric compound, an dsRNA mimetic that has been shown
to have excellent hybridization properties, is referred to as a
peptide nucleic acid (PNA). In PNA compounds, the sugar backbone of
an dsRNA is replaced with an amide containing backbone, in
particular an aminoethylglycine backbone. The nucleobases are
retained and are bound directly or indirectly to aza nitrogen atoms
of the amide portion of the backbone. Representative U.S. patents
that teach the preparation of PNA compounds include, but are not
limited to, U.S. Pat. Nos. 5,539,082; 5,714,331; and 5,719,262,
each of which is herein incorporated by reference. Further teaching
of PNA compounds can be found in Nielsen et al., Science, 1991,
254, 1497-1500.
[0075] Most preferred embodiments of the invention are dsRNAs with
phosphorothioate backbones and oligonucleosides with heteroatom
backbones, and in particular --CH.sub.2--NH--CH.sub.2--,
--CH.sub.2--N(CH.sub.3)--O--CH.sub.2--[known as a methylene
(methylimino) or MMI backbone],
--CH.sub.2--O--N(CH.sub.3)--CH.sub.2--,
--CH.sub.2--N(CH.sub.3)--N(CH.sub.3)--CH.sub.2-- and
--N(CH.sub.3)--CH.sub.2--CH.sub.2--[wherein the native
phosphodiester backbone is represented as --O--P--O--CH.sub.2--] of
the above-referenced U.S. Pat. No. 5,489,677, and the amide
backbones of the above-referenced U.S. Pat. No. 5,602,240. Also
preferred are dsRNAs having morpholino backbone structures of the
above-referenced U.S. Pat. No. 5,034,506.
[0076] Modified dsRNAs may also contain one or more substituted
sugar moieties. Preferred dsRNAs comprise one of the following at
the 2' position: OH; F; O-, S-, or N-alkyl; O-, S-, or N-alkenyl;
O-, S- or N-alkynyl; or O-alkyl-O-alkyl, wherein the alkyl, alkenyl
and alkynyl may be substituted or unsubstituted C.sub.1 to C.sub.10
alkyl or C.sub.2 to C.sub.10 alkenyl and alkynyl. Particularly
preferred are O[(CH.sub.2).sub.nO].sub.mCH.sub.3,
O(CH.sub.2).sub.nOCH.sub.3, O(CH.sub.2).sub.nNH.sub.2,
O(CH.sub.2).sub.nCH.sub.3, O(CH.sub.2).sub.nONH.sub.2, and
O(CH.sub.2).sub.nON[(CH.sub.2).sub.nCH.sub.3)].sub.2, where n and m
are from 1 to about 10. Other preferred dsRNAs comprise one of the
following at the 2' position: C.sub.1 to C.sub.10 lower alkyl,
substituted lower alkyl, alkaryl, aralkyl, O-alkaryl or O-aralkyl,
SH, SCH.sub.3, OCN, Cl, Br, CN, CF.sub.3, OCF.sub.3, SOCH.sub.3,
SO.sub.2CH.sub.3, ONO.sub.2, NO.sub.2, N.sub.3, NH.sub.2,
heterocycloalkyl, heterocycloalkaryl, aminoalkylamino,
polyalkylamino, substituted silyl, an RNA cleaving group, a
reporter group, an intercalator, a group for improving the
pharmacokinetic properties of an dsRNA, or a group for improving
the pharmacodynamic properties of an dsRNA, and other substituents
having similar properties. A preferred modification includes
2'-methoxyethoxy (2'-O--CH.sub.2CH.sub.2OCH.sub.3, also known as
2'-O-(2-methoxyethyl) or 2'-MOE) (Martin et al., Helv. Chim. Acta,
1995, 78, 486-504) i.e., an alkoxy-alkoxy group. A further
preferred modification includes 2'-dimethylaminooxyethoxy, i.e., a
O(CH.sub.2).sub.2ON(CH.sub.3).sub.2 group, also known as 2'-DMAOE,
as described in examples herein below, and
2'-dimethylaminoethoxyethoxy (also known in the art as
2'-O-dimethylaminoethoxyethyl or 2'-DMAEOE), i.e.,
2'--O--CH.sub.2--O--CH.sub.2--N(CH.sub.2).sub.2, also described in
examples herein below.
[0077] Other preferred modifications include 2'-methoxy
(2'-OCH.sub.3), 2'-aminopropoxy
(2'-OCH.sub.2CH.sub.2CH.sub.2NH.sub.2) and 2'-fluoro (2'-F).
Similar modifications may also be made at other positions on the
dsRNA, particularly the 3' position of the sugar on the 3' terminal
nucleotide or in 2'-5' linked dsRNAs and the 5' position of 5'
terminal nucleotide. DsRNAs may also have sugar mimetics such as
cyclobutyl moieties in place of the pentofuranosyl sugar.
Representative U.S. patents that teach the preparation of such
modified sugar structures include, but are not limited to, U.S.
Pat. Nos. 4,981,957; 5,118,800; 5,319,080; 5,359,044; 5,393,878;
5,446,137; 5,466,786; 5,514,785; 5,519,134; 5,567,811; 5,576,427;
5,591,722; 5,597,909; 5,610,300; 5,627,053; 5,639,873; 5,646,265;
5,658,873; 5,670,633; and 5,700,920, certain of which are commonly
owned with the instant application, and each of which is herein
incorporated by reference in its entirety.
[0078] DsRNAs may also include nucleobase (often referred to in the
art simply as "base") modifications or substitutions. As used
herein, "unmodified" or "natural" nucleobases include the purine
bases adenine (A) and guanine (G), and the pyrimidine bases thymine
(T), cytosine (C) and uracil (U). Modified nucleobases include
other synthetic and natural nucleobases such as 5-methylcytosine
(5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine,
2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and
guanine, 2-propyl and other alkyl derivatives of adenine and
guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine,
5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo
uracil, cytosine and thymine, 5-uracil (pseudouracil),
4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl
anal other 8-substituted adenines and guanines, 5-halo,
particularly 5-bromo, 5-trifluoromethyl and other 5-substituted
uracils and cytosines, 7-methylguanine and 7-methyladenine,
8-azaguanine and 8-azaadenine, 7-deazaguanine and 7-daazaadenine
and 3-deazaguanine and 3-deazaadenine. Further nucleobases include
those disclosed in U.S. Pat. No. 3,687,808, those disclosed in The
Concise Encyclopedia Of Polymer Science And Engineering, pages
858-859, Kroschwitz, J. L, ed. John Wiley & Sons, 1990, these
disclosed by Englisch et al., Angewandte Chemie, International
Edition, 1991, 30, 613, and those disclosed by Sanghvi, Y S.,
Chapter 15, DsRNA Research and Applications, pages 289-302, Crooke,
S. T. and Lebleu, B., Ed., CRC Press, 1993. Certain of these
nucleobases are particularly useful for increasing the binding
affinity of the oligomeric compounds of the invention. These
include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6
and O-6 substituted purines, including 2-aminopropyladenine,
5-propynyluracil and 5-propynylcytosine. 5-methylcytosine
substitutions have been shown to increase nucleic acid duplex
stability by 0.6-1.2.degree. C. (Sanghvi, Y. S., Crooke, S. T. and
Lebleu, B., Eds., DsRNA Research and Applications, CRC Press, Boca
Raton, 1993, pp. 276-278) and are presently preferred base
substitutions, even more particularly when combined with
2'-.beta.-methoxyethyl sugar modifications.
[0079] Representative U.S. patents that teach the preparation of
certain of the above noted modified nucleobases as well as other
modified nucleobases include, but are not limited to, the above
noted U.S. Pat. No. 3,687,808, as well as U.S. Pat. Nos. 4,845,205;
5,130,30; 5,134,066; 5,175,273; 5,367,066; 5,432,272; 5,457,187;
5,459,255; 5,484,908; 5,502,177; 5,525,711; 5,552,540; 5,587,469;
5,594,121, 5,596,091; 5,614,617; and 5,681,941, each of which is
herein incorporated by reference, and U.S. Pat. No. 5,750,692, also
herein incorporated by reference.
[0080] Conjugates
[0081] Another modification of the dsRNAs of the invention involves
chemically linking to the dsRNA one or more moieties or conjugates
which enhance the activity, cellular distribution or cellular
uptake of the dsRNA. Such moieties include but are not limited to
lipid moieties such as a cholesterol moiety (Letsinger et al.,
Proc. Natl. Acid. Sci. USA, 199, 86, 6553-6556), cholic acid
(Manoharan et al., Biorg. Med. Chem. Let., 1994 4 1053-1060), a
thioether, e.g., beryl-S-tritylthiol (Manoharan et al., Ann. N.Y.
Acad. Sci., 1992, 660, 306-309; Manoharan et al., Biorg. Med. Chem.
Let., 1993, 3, 2765-2770), a thiocholesterol (Oberhauser et al.,
Nucl. Acids Res., 1992, 20, 533-538), an aliphatic chain, e.g.,
dodecandiol or undecyl residues (Saison-Behmoaras et al., EMBO J,
1991, 10, 1111-1118; Kabanov et al., FEBS Lett., 1990, 259,
327-330; Svinarchuk et al., Biochimie, 1993, 75, 49-54), a
phospholipid, e.g., di-hexadecyl-rac-glycerol or triethyl-ammonium
1,2-di-O-hexadecyl-rac-glycero-3-Hphosphonate (Manoharan et al.,
Tetrahedron Lett., 1995, 36, 3651-3654; Shea et al., Nucl. Acids
Res., 1990, 18, 3777-3783), a polyamine or a polyethylene glycol
chain (Manoharan et al., Nucleosides & Nucleotides, 1995, 14,
969-973), or adamantane acetic acid (Manoharan et al., Tetrahedron
Lett., 1995, 36, 3651-3654), a palmityl moiety (Mishra et al.,
Biochim. Biophys. Acta, 1995, 1264, 229-237), or an octadecylamine
or hexylamino-carbonyloxycholesterol moiety (Crooke et al., J.
Pharmacol. Exp. Ther., 1996, 277, 923-937).
[0082] Representative U.S. patents that teach the preparation of
such dsRNA conjugates include, but are not limited to, U.S. Pat.
Nos. 4,828,979; 4,948,882; 5,218,105; 5,525,465; 5,541,313;
5,545,730; 5,552,538; 5,578,717, 5,580,731; 5,591,584; 5,109,124;
5,118,802; 5,138,045; 5,414,077; 5,486,603; 5,512,439; 5,578,718;
5,608,046; 4,587,044; 4,605,735; 4,667,025; 4,762,779; 4,789,737;
4,824,941; 4,835,263; 4,876,335; 4,904,582; 4,958,013; 5,082,830;
5,112,963; 5,214,136; 5,082,830; 5,112,963; 5,214,136; 5,245,022;
5,254,469; 5,258,506; 5,262,536; 5,272,250; 5,292,873; 5,317,098;
5,371,241, 5,391,723; 5,416,203, 5,451,463; 5,510,475; 5,512,667;
5,514,785; 5,565,552; 5,567,810; 5,574,142; 5,585,481; 5,587,371;
5,595,726; 5,597,696; 5,599,923; 5,599,928 and 5,688,941, each of
which is herein incorporated by reference.
[0083] It is not necessary for all positions in a given compound to
be uniformly modified, and in fact more than one of the
aforementioned modifications may be incorporated in a single
compound or even at a single nucleoside within an dsRNA. The
present invention also includes dsRNA compounds which are chimeric
compounds. "Chimeric" dsRNA compounds or "chimeras," in the context
of this invention, are dsRNA compounds, particularly dsRNAs, which
contain two or more chemically distinct regions, each made up of at
least one monomer unit, i.e., a nucleotide in the case of an dsRNA
compound. These dsRNAs typically contain at least one region
wherein the dsRNA is modified so as to confer upon the dsRNA
increased resistance to nuclease degradation, increased cellular
uptake, and/or increased binding affinity for the target nucleic
acid. An additional region of the dsRNA may serve as a substrate
for enzymes capable of cleaving RNA:DNA or RNA:RNA hybrids. By way
of example, RNase H is a cellular endonuclease which cleaves the
RNA strand of an RNA:DNAduplex. Activation of RNase H, therefore,
results in cleavage of the RNA target, thereby greatly enhancing
the efficiency of dsRNA inhibition of gene expression.
Consequently, comparable results can often be obtained with shorter
dsRNAs when chimeric dsRNAs are used, compared to phosphorothioate
deoxy dsRNAs hybridizing to the same target region. Cleavage of the
RNA target can be routinely detected by gel electrophoresis and, if
necessary, associated nucleic acid hybridization techniques known
in the art.
[0084] In certain instances, the dsRNA may be modified by a
non-ligand group. A number of non-ligand molecules have been
conjugated to dsRNAs in order to enhance the activity, cellular
distribution or cellular uptake of the dsRNA, and procedures for
performing such conjugations are available in the scientific
literature. Such non-ligand moieties have included lipid moieties,
such as cholesterol (Letsinger et al., Proc. Natl. Acad. Sci. USA,
1989, 86:6553), cholic acid (Manoharan et al., Bioorg. Med. Chem.
Lett., 1994, 4:1053), a thioether, e.g., hexyl-5-tritylthiol
(Manoharan et al., Ann. N.Y. Acad. Sci., 1992, 660:306; Manoharan
et al., Bioorg. Med. Chem. Let., 1993, 3:2765), a thiocholesterol
(Oberhauser et al., Nucl. Acids Res., 1992, 20:533), an aliphatic
chain, e.g., dodecandiol or undecyl residues (Saison-Behmoaras et
al., EMBO J., 1991, 10:111; Kabanov et al., FEBS Lett., 1990,
259:327; Svinarchuk et al., Biochimie, 1993, 75:49), a
phospholipid, e.g., di-hexadecyl-rac-glycerol or triethylammonium
1,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate (Manoharan et al.,
Tetrahedron Lett., 1995, 36:3651; Shea et al., Nucl. Acids Res.,
1990, 18:3777), a polyamine or a polyethylene glycol chain
(Manoharan et al., Nucleosides & Nucleotides, 1995, 14:969), or
adamantane acetic acid (Manoharan et al., Tetrahedron Lett., 1995,
36:3651), a palmityl moiety (Mishra et al., Biochim. Biophys. Acta,
1995, 1264:229), or an octadecylamine or
hexylamino-carbonyl-oxycholesterol moiety (Crooke et al., J.
Pharmacol. Exp. Ther., 1996, 277:923). Representative United States
patents that teach the preparation of such dsRNA conjugates have
been listed above. Typical conjugation protocols involve the
synthesis of dsRNAs bearing an aminolinker at one or more positions
of the sequence. The amino group is then reacted with the molecule
being conjugated using appropriate coupling or activating reagents.
The conjugation reaction may be performed either with the dsRNA
still bound to the solid support or following cleavage of the dsRNA
in solution phase. Purification of the dsRNA conjugate by HPLC
typically affords the pure conjugate.
[0085] Vector Encoded siRNA Agents
[0086] In another aspect of the invention, GSK-3 specific dsRNA
molecules that are expressed from transcription units inserted into
DNA or RNA vectors (see, e.g., Couture, A, et al., TIG. (1996),
12:5-10; Skillern, A., et al., International PCT Publication No. WO
00/22113, Conrad, International PCT Publication No. WO 00/22114,
and Conrad, U.S. Pat. No. 6,054,299). These transgenes can be
introduced as a linear construct, a circular plasmid, or a viral
vector, which can be incorporated and inherited as a transgene
integrated into the host genome. The transgene can also be
constructed to permit it to be inherited as an extrachromosomal
plasmid (Gassmann, et al., Proc. Natl. Acad. Sci. USA (1995)
92:1292).
[0087] The individual strands of a dsRNA can be transcribed by
promoters on two separate expression vectors and co-transfected
into a target cell. Alternatively each individual strand of the
dsRNA can be transcribed by promoters both of which are located on
the same expression plasmid. In a preferred embodiment, a dsRNA is
expressed as an inverted repeat joined by a linker polynucleotide
sequence such that the dsRNA has a stem and loop structure.
[0088] The recombinant dsRNA expression vectors are generally DNA
plasmids or viral vectors. dsRNA expressing viral vectors can be
constructed based on, but not limited to, adeno-associated virus
(for a review, see Muzyczka, et al., Curr. Topics Micro. Immunol.
(1992) 158:97-129)); adenovirus (see, for example, Berkner, et al.,
BioTechniques (1998) 6:616), Rosenfeld et al. (1991, Science
252:431-434), and Rosenfeld et al. (1992), Cell 68:143-155)); or
alphavirus as well as others known in the art. Retroviruses have
been used to introduce a variety of genes into many different cell
types, including epithelial cells, in vitro and/or in vivo (see,
e.g., Eglitis, et al., Science (1985) 230:1395-1398; Danos and
Mulligan, Proc. Natl. Acad. Sci. USA (1998) 85:6460-6464; Wilson et
al., 1988, Proc. Natl. Acad. Sci. USA 85:3014-3018; Armentano et
al., 1990, Proc. Natl. Acad. Sci. USA 87:61416145; Huber et al.,
1991, Proc. Natl. Acad. Sci. USA 88:8039-8043; Ferry et al., 1991,
Proc. Natl. Acad. Sci. USA 88:8377-8381; Chowdhury et al., 1991,
Science 254:1802-1805; van Beusechem. et al., 1992, Proc. Nad.
Acad. Sci. USA 89:7640-19; Kay et al., 1992, Human Gene Therapy
3:641-647; Dai et al., 1992, Proc. Natl. Acad. Sci. USA
89:10892-10895; Hwu et al., 1993, J. Immunol. 150:4104-4115; U.S.
Pat. No. 4,868,116; U.S. Pat. No. 4,980,286; PCT Application WO
89/07136; PCT Application WO 89/02468; PCT Application WO 89/05345;
and PCT Application WO 92/07573). Recombinant retroviral vectors
capable of transducing and expressing genes inserted into the
genome of a cell can be produced by transfecting the recombinant
retroviral genome into suitable packaging cell lines such as PA317
and Psi-CRIP (Comette et al., 1991, Human Gene Therapy 2:5-10; Cone
et al., 1984, Proc. Natl. Acad. Sci. USA 81:6349). Recombinant
adenoviral vectors can be used to infect a wide variety of cells
and tissues in susceptible hosts (e.g., rat, hamster, dog, and
chimpanzee) (Hsu et al., 1992, J. Infectious Disease, 166:769), and
also have the advantage of not requiring mitotically active cells
for infection.
[0089] Any viral vector capable of accepting the coding sequences
for the dsRNA molecule(s) to be expressed can be used, for example
vectors derived from adenovirus (AV); adeno-associated virus (AAV);
retroviruses (e.g., lentiviruses (LV), Rhabdoviruses, murine
leukemia virus); herpes virus, and the like. The tropism of viral
vectors can be modified by pseudotyping the vectors with envelope
proteins or other surface antigens from other viruses, or by
substituting different viral capsid proteins, as appropriate.
[0090] For example, lentiviral vectors of the invention can be
pseudotyped with surface proteins from vesicular stomatitis virus
(VSV), rabies, Ebola, Mokola, and the like. AAV vectors of the
invention can be made to target different cells by engineering the
vectors to express different capsid protein serotypes. For example,
an AAV vector expressing a serotype 2 capsid on a serotype 2 genome
is called AAV 2/2. This serotype 2 capsid gene in the AAV 2/2
vector can be replaced by a serotype 5 capsid gene to produce an
AAV 2/5 vector. Techniques for constructing AAV vectors which
express different capsid protein serotypes are within the skill in
the art; see, e.g., Rabinowitz J E et al. (2002), J Virol
76:791-801, the entire disclosure of which is herein incorporated
by reference.
[0091] Selection of recombinant viral vectors suitable for use in
the invention, methods for inserting nucleic acid sequences for
expressing the dsRNA into the vector, and methods of delivering the
viral vector to the cells of interest are within the skill in the
art. See, for example, Dornburg R (1995), Gene Therap. 2: 301-310;
Eglitis M A (1988), Biotechniques 6: 608-614; Miller A D (1990),
Hum Gene Therap. 1: 5-14; Anderson W F (1998), Nature 392: 25-30;
and Rubinson D A et al., Nat. Genet. 33: 401-406, the entire
disclosures of which are herein incorporated by reference.
[0092] Preferred viral vectors are those derived from AV and AAV.
In a particularly preferred embodiment, the dsRNA of the invention
is expressed as two separate, complementary single-stranded RNA
molecules from a recombinant AAV vector having, for example, either
the U6 or H1 RNA promoters, or the cytomegalovirus (CMV)
promoter.
[0093] A suitable AV vector for expressing the dsRNA of the
invention, a method for constructing the recombinant AV vector, and
a method for delivering the vector into target cells, are described
in Xia H et al. (2002), Nat. Biotech. 20: 1006-1010.
[0094] Suitable AAV vectors for expressing the dsRNA of the
invention, methods for constructing the recombinant AV vector, and
methods for delivering the vectors into target cells are described
in Samulski Ret al. (1987), J. Virol. 61: 3096-3101; Fisher K Jet
al. (1996), J. Virol, 70: 520-532; Samulski R et al. (1989), J.
Virol. 63: 3822-3826; U.S. Pat. No. 5,252,479; U.S. Pat. No.
5,139,941; International Patent Application No. WO 94/13788; and
International Patent Application No. WO 93/24641, the entire
disclosures of which are herein incorporated by reference.
[0095] The promoter driving dsRNA expression in either a DNA
plasmid or viral vector of the invention may be a eukaryotic RNA
polymerase I (e.g. ribosomal RNA promoter), RNA polymerase II (e.g.
CMV early promoter or actin promoter or Ul snRNA promoter) or
generally RNA polymerase III promoter (e.g. U6 snRNA or 7SK RNA
promoter) or a prokaryotic promoter, for example the T7 promoter,
provided the expression plasmid also encodes T7 RNA polymerase
required for transcription from a T7 promoter. The promoter can
also direct transgene expression to the pancreas (see, e.g., the
insulin regulatory sequence for pancreas (Bucchini et al., 1986,
Proc. Natl. Acad. Sci. USA 83:2511-2515)).
[0096] In addition, expression of the transgene can be precisely
regulated, for example, by using an inducible regulatory sequence
and expression systems such as a regulatory sequence that is
sensitive to certain physiological regulators, e.g., circulating
glucose levels, or hormones (Docherty et al., 1994, FASEB J.
8:20-24). Such inducible expression systems, suitable for the
control of transgene expression in cells or in mammals include
regulation by ecdysone, by estrogen, progesterone, tetracycline,
chemical inducers of dimerization, and
isopropyl-beta-D1-thiogalactopyranoside (EPTG). A person skilled in
the art would be able to choose the appropriate regulatory/promoter
sequence based on the intended use of the dsRNA transgene.
[0097] Generally, recombinant vectors capable of expressing dsRNA
molecules are delivered as described below, and persist in target
cells. Alternatively, viral vectors can be used that provide for
transient expression of dsRNA molecules. Such vectors can be
repeatedly administered as necessary. Once expressed, the dsRNAs
bind to target RNA and modulate its function or expression.
Delivery of dsRNA expressing vectors can be systemic, such as by
intravenous or intramuscular administration, by administration to
target cells ex-planted from the patient followed by reintroduction
into the patient, or by any other means that allows for
introduction into a desired target cell.
[0098] dsRNA expression DNA plasmids are typically transfected into
target cells as a complex with cationic lipid carriers (e.g.
Oligofectamine) or non-cationic lipid-based carriers (e.g.
Transit-TKO.TM.). Multiple lipid transfections for dsRNA-mediated
knockdowns targeting different regions of a single GSK-3 gene or
two GSK-3 genes over a period of a week or more are also
contemplated by the invention. Successful introduction of the
vectors of the invention into host cells can be monitored using
various known methods. For example, transient transfection. can be
signaled with a reporter, such as a fluorescent marker, such as
Green Fluorescent Protein (GFP). Stable transfection of ex vivo
cells can be ensured using markers that provide the transfected
cell with resistance to specific environmental factors (e.g.,
antibiotics and drugs), such as hygromycin B resistance.
[0099] The GSK-3 specific dsRNA molecules can also be inserted into
vectors and used as gene therapy vectors for human patients. Gene
therapy vectors can be delivered to a subject by, for example,
intravenous injection, local administration (see U.S. Pat. No.
5,328,470) or by stereotactic injection (see e.g., Chen et al.
(1994) Proc. Natl. Acad. Sci. USA 91:3054-3057). The pharmaceutical
preparation of the gene therapy vector can include the gene therapy
vector in an acceptable diluent, or can include a slow release
matrix in which the gene delivery vehicle is imbedded.
Alternatively, where the complete gene delivery vector can be
produced intact from recombinant cells, e.g., retroviral vectors,
the pharmaceutical preparation can include one or more cells which
produce the gene delivery system.
III. PHARMACEUTICAL COMPOSITIONS COMPRISING dsRNA
[0100] In one embodiment, the invention provides pharmaceutical
compositions comprising a dsRNA, as described herein, and a
pharmaceutically acceptable carrier. The pharmaceutical composition
comprising the dsRNA is useful for treating a disease or disorder
associated with the expression or activity of a GSK-3 gene, such as
pathological processes mediated by GSK-3 expression. Such
pharmaceutical compositions are formulated based on the mode of
delivery. One example is compositions that are formulated for
systemic administration via parenteral delivery.
[0101] The pharmaceutical compositions featured herein are
administered in dosages sufficient to inhibit expression of a GSK-3
gene. In general, a suitable dose of dsRNA will be in the range of
0.01 to 200.0 milligrams per kilogram body weight of the recipient
per day, generally in the range of 1 to 50 mg per kilogram body
weight per day. For example, the dsRNA can be administered at 0.01
mg/kg, 0.05 mg/kg, 0.5 mg/kg, 1 mg/kg, 1.5 mg/kg, 2 mg/kg, 3 mg/kg,
5.0 mg/kg, 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, or 50 mg/kg per
single dose.
[0102] The pharmaceutical composition may be administered once
daily or the dsRNA may be administered as two, three, or more
sub-doses at appropriate intervals throughout the day or even using
continuous infusion or delivery through a controlled release
formulation. In that case, the dsRNA contained in each sub-dose
must be correspondingly smaller in order to achieve the total daily
dosage. The dosage unit can also be compounded for delivery over
several days, e.g., using a conventional sustained release
formulation which provides sustained release of the dsRNA over a
several day period. Sustained release formulations are well known
in the art and are particularly useful for delivery of agents at a
particular site, such as could be used with the agents of the
present invention. In this embodiment, the dosage unit contains a
corresponding multiple of the daily dose.
[0103] The skilled artisan will appreciate that certain factors may
influence the dosage and timing required to effectively treat a
subject, including but not limited to the severity of the disease
or disorder, previous treatments, the general health and/or age of
the subject, and other diseases present. Moreover, treatment of a
subject with a therapeutically effective amount of a composition
can include a single treatment or a series of treatments. Estimates
of effective dosages and in vivo half-lives for the individual
dsRNAs encompassed by the invention can be made using conventional
methodologies or on the basis of in vivo testing using an
appropriate animal model, as described elsewhere herein.
[0104] Advances in mouse genetics have generated a number of mouse
models for the study of various human diseases, such as
pathological processes mediated by GSK-3 expression. Such models
are used for in vivo testing of dsRNA, as well as for determining a
therapeutically effective dose.
[0105] The data obtained from cell culture assays and animal
studies can be used in formulating a range of dosage for use in
humans. The dosage of compositions featured in the invention lies
generally within a range of circulating concentrations that include
the ED50 with little or no toxicity. The dosage may vary within
this range depending upon the dosage form employed and the route of
administration utilized. For any compound used in the methods
featured in the invention, the therapeutically effective dose can
be estimated initially from cell culture assays. A dose may be
formulated in animal models to achieve a circulating plasma
concentration range of the compound or, when appropriate, of the
polypeptide product of a target sequence (e.g., achieving a
decreased concentration of the polypeptide) that includes the IC50
(i.e., the concentration of the test compound which achieves a
half-maximal inhibition of symptoms) as determined in cell culture.
Such information can be used to more accurately determine useful
doses in humans. Levels in plasma may be measured, for example, by
high performance liquid chromatography.
[0106] The dsRNAs featured in the invention can be administered in
combination with other known agents effective in treatment of
pathological processes mediated by target gene expression. In any
event, the administering physician can adjust the amount and timing
of dsRNA administration on the basis of results observed using
standard measures of efficacy known in the art or described
herein.
[0107] Administration
[0108] The present invention also includes pharmaceutical
compositions and formulations which include the dsRNA compounds of
the invention. The pharmaceutical compositions of the present
invention may be administered in a number of ways depending upon
whether local or systemic treatment is desired and upon the area to
be treated. Administration may be topical, pulmonary, e.g., by
inhalation or insufflation of powders or aerosols, including by
nebulizer; intratracheal, intranasal, epidermal and transdermal),
oral or parenteral. Parenteral administration includes intravenous,
intraarterial, subcutaneous, intraperitoneal or intramuscular
injection or infusion; or intracranial, e.g., intrathecal or
intraventricular, administration. In one embodiment, the
pharmaceutical composition is administered intracranially, directly
into the nucleus accumbens.
[0109] Pharmaceutical compositions and formulations for topical
administration may include transdermal patches, ointments, lotions,
creams, gels, drops, suppositories, sprays, liquids and powders.
Conventional pharmaceutical carriers, aqueous, powder or oily
bases, thickeners and the like may be necessary or desirable.
Coated condoms, gloves and the like may also be useful. Preferred
topical formulations include those in which the dsRNAs of the
invention are in admixture with a topical delivery agent such as
lipids, liposomes, fatty acids, fatty acid esters, steroids,
chelating agents and surfactants. Preferred lipids and liposomes
include neutral (e.g. dioleoylphosphatidyl DOPE ethanolamine,
dimyristoylphosphatidyl choline DMPC, distearolyphosphatidyl
choline) negative (e.g. dimyristoylphosphatidyl glycerol DMPG) and
cationic (e.g. dioleoyltetramethylaminopropyl DOTAP and
dioleoylphosphatidyl ethanolamine DOTMA). DsRNAs of the invention
may be encapsulated within liposomes or may form complexes thereto,
in particular to cationic liposomes. Alternatively, dsRNAs may be
complexed to lipids, in particular to cationic lipids. Preferred
fatty acids and esters include but are not limited arachidonic
acid, oleic acid, eicosanoic acid, lauric acid, caprylic acid,
capric acid, myristic acid, palmitic acid, stearic acid, linoleic
acid, linolenic acid, dicaprate, tricaprate, monoolein, dilaurin,
glyceryl 1-monocaprate, 1-dodecylazacycloheptan-2-one, an
acylcarnitine, an acylcholine, or a C.sub.1-10 alkyl ester (e.g.
isopropylmyristate IPM), monoglyceride, diglyceride or
pharmaceutically acceptable salt thereof. Topical formulations are
described in detail in U.S. patent application Ser. No. 09/315,298
filed on May 20, 1999 which is incorporated herein by reference in
its entirety.
[0110] Compositions and formulations for oral administration
include powders or granules, microparticulates, nanoparticulates,
suspensions or solutions in water or non-aqueous media, capsules,
gel capsules, sachets, tablets or minitablets. Thickeners,
flavoring agents, diluents, emulsifiers, dispersing aids or binders
may be desirable. Preferred oral formulations are those in which
dsRNAs of the invention are administered in conjunction with one or
more penetration enhancers surfactants and chelators. Preferred
surfactants include fatty acids and/or esters or salts thereof,
bile acids and/or salts thereof. Preferred bile acids/salts include
chenodeoxycholic acid (CDCA) and ursodeoxychenodeoxycholic acid
(UDCA), cholic acid, dehydrocholic acid, deoxycholic acid,
glucholic acid, glycholic acid, glycodeoxycholic acid, taurocholic
acid, taurodeoxycholic acid, sodium tauro-24,25-dihydro-fusidate
and sodium glycodihydrofusidate. Preferred fatty acids include
arachidonic acid, undecanoic acid, oleic acid, lauric acid,
caprylic acid, capric acid, myristic acid, palmitic acid, stearic
acid, linoleic acid, linolenic acid, dicaprate, tricaprate,
monoolein, dilaurin, glyceryl 1-monocaprate,
1-dodecylazacycloheptan-2-one, an acylcarnitine, an acylcholine, or
a monoglyceride, a diglyceride or a pharmaceutically acceptable
salt thereof (e.g. sodium). Also preferred are combinations of
penetration enhancers, for example, fatty acids/salts in
combination with bile acids/salts. A particularly preferred
combination is the sodium salt of lauric acid, capric acid and
UDCA. Further penetration enhancers include
polyoxyethylene-9-lauryl ether, polyoxyethylene-20-cetyl ether.
DsRNAs of the invention may be delivered orally, in granular form
including sprayed dried particles, or complexed to form micro or
nanoparticles. DsRNA complexing agents include poly-amino acids;
polyimines; polyacrylates; polyalkylacrylates, polyoxethanes,
polyalkylcyanoacrylates; cationized gelatins, albumins, starches,
acrylates, polyethyleneglycols (PEG) and starches;
polyalkylcyanoacrylates; DEAE-derivatized polyimines, pollulans,
celluloses and starches. Particularly preferred complexing agents
include chitosan, N-trimethylchitosan, poly-L-lysine,
polyhistidine, polyornithine, polyspermines, protamine,
polyvinylpyridine, polythiodiethylaminomethylethylene P(TDAE),
polyaminostyrene (e.g. p-amino), poly(methylcyanoacrylate),
poly(ethylcyanoacrylate), poly(butylcyanoacrylate),
poly(isobutylcyanoacrylate), poly(isohexylcynaoacrylate),
DEAE-methacrylate, DEAE-hexylacrylate, DEAE-acrylamide,
DEAE-albumin and DEAE-dextran, polymethylacrylate,
polyhexylacrylate, poly(D,L-lactic acid),
poly(DL-lactic-co-glycolic acid (PLGA), alginate, and
polyethyleneglycol (PEG). Oral formulations for dsRNAs and their
preparation are described in detail in U.S. application. Ser. No.
08/886,829 (filed Jul. 1, 1997), Ser. No. 09/108,673 (filed Jul. 1,
1998), Ser. No. 09/256,515 (filed Feb. 23, 1999), Ser. No.
09/082,624 (filed May 21, 1998) and Ser. No. 09/315,298 (filed May
20, 1999), each of which is incorporated herein by reference in
their entirety.
[0111] Compositions and formulations for parenteral, intrathecal,
intraventricular or intrahepatic administration may include sterile
aqueous solutions which may also contain buffers, diluents and
other suitable additives such as, but not limited to, penetration
enhancers, carrier compounds and other pharmaceutically acceptable
carriers or excipients.
[0112] Pharmaceutical compositions of the present invention
include, but are not limited to, solutions, emulsions, and
liposome-containing formulations. These compositions may be
generated from a variety of components that include, but are not
limited to, preformed liquids, self-emulsifying solids and
self-emulsifying semisolids. Particularly preferred are
formulations that target the liver when treating hepatic disorders
such as hepatic carcinoma.
[0113] The pharmaceutical formulations of the present invention,
which may conveniently be presented in unit dosage form, may be
prepared according to conventional techniques well known in the
pharmaceutical industry. Such techniques include the step of
bringing into association the active ingredients with the
pharmaceutical carrier(s) or excipient(s). In general, the
formulations are prepared by uniformly and intimately bringing into
association the active ingredients with liquid carriers or finely
divided solid carriers or both, and then, if necessary, shaping the
product.
[0114] The compositions of the present invention may be formulated
into any of many possible dosage forms such as, but not limited to,
tablets, capsules, gel capsules, liquid syrups, soft gels,
suppositories, and enemas. The compositions of the present
invention may also be formulated as suspensions in aqueous,
non-aqueous or mixed media. Aqueous suspensions may further contain
substances which increase the viscosity of the suspension
including, for example, sodium carboxymethylcellulose, sorbitol
and/or dextran. The suspension may also contain stabilizers.
[0115] Emulsions
[0116] The compositions of the present invention may be prepared
and formulated as emulsions. Emulsions are typically heterogenous
systems of one liquid dispersed in another in the form of droplets
usually exceeding 0.1 .mu.m in diameter (Idson, in Pharmaceutical
Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel
Dekker, Inc., New York, N.Y., volume 1, p. 199; Rosoff, in
Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.),
1988, Marcel Dekker, Inc., New York, N.Y., Volume 1, p. 245; Block
in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker
(Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 2, p.
335; Higuchi et al., in Remington's Pharmaceutical Sciences, Mack
Publishing Co., Easton, Pa., 1985, p. 301). Emulsions are often
biphasic systems comprising two immiscible liquid phases intimately
mixed and dispersed with each other. In general, emulsions may be
of either the water-in-oil (w/o) or the oil-in-water (o/w) variety.
When an aqueous phase is finely divided into and dispersed as
minute droplets into a bulk oily phase, the resulting composition
is called a water-in-oil (w/o) emulsion. Alternatively, when an
oily phase is finely divided into and dispersed as minute droplets
into a bulk aqueous phase, the resulting composition is called an
oil-in-water (o/w) emulsion. Emulsions may contain additional
components in addition to the dispersed phases, and the active drug
which may be present as a solution in either the aqueous phase,
oily phase or itself as a separate phase. Pharmaceutical excipients
such as emulsifiers, stabilizers, dyes, and anti-oxidants may also
be present in emulsions as needed. Pharmaceutical emulsions may
also be multiple emulsions that are comprised of more than two
phases such as, for example, in the case of oil-in-water-in-oil
(o/w/o) and water-in-oil-in-water (w/o/w) emulsions. Such complex
formulations often provide certain advantages that simple binary
emulsions do not. Multiple emulsions in which individual oil
droplets of an o/w emulsion enclose small water droplets constitute
a w/o/w emulsion. Likewise a system of oil droplets enclosed in
globules of water stabilized in an oily continuous phase provides
an o/w/o emulsion.
[0117] Emulsions are characterized by little or no thermodynamic
stability. Often, the dispersed or discontinuous phase of the
emulsion is well dispersed into the external or continuous phase
and maintained in this form through the means of emulsifiers or the
viscosity of the formulation. Either of the phases of the emulsion
may be a semisolid or a solid, as is the case of emulsion-style
ointment bases and creams. Other means of stabilizing emulsions
entail the use of emulsifiers that may be incorporated into either
phase of the emulsion. Emulsifiers may broadly be classified into
four categories: synthetic surfactants, naturally occurring
emulsifiers, absorption bases, and finely dispersed solids (Idson,
in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker
(Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p.
199).
[0118] Synthetic surfactants, also known as surface active agents,
have found wide applicability in the formulation of emulsions and
have been reviewed in the literature (Rieger, in Pharmaceutical
Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel
Dekker, Inc., New York, N.Y., volume 1, p. 285; Idson, in
Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.),
Marcel Dekker, Inc., New York, N.Y., 1988, volume 1, p. 199).
Surfactants are typically amphiphilic and comprise a hydrophilic
and a hydrophobic portion. The ratio of the hydrophilic to the
hydrophobic nature of the surfactant has been termed the
hydrophile/lipophile balance (HLB) and is a valuable tool in
categorizing and selecting surfactants in the preparation of
formulations. Surfactants may be classified into different classes
based on the nature of the hydrophilic group: nonionic, anionic,
cationic and amphoteric (Rieger, in Pharmaceutical Dosage Forms,
Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New
York, N.Y., volume 1, p. 285).
[0119] Naturally occurring emulsifiers used in emulsion
formulations include lanolin, beeswax, phosphatides, lecithin and
acacia. Absorption bases possess hydrophilic properties such that
they can soak up water to form w/o emulsions yet retain their
semisolid consistencies, such as anhydrous lanolin and hydrophilic
petrolatum. Finely divided solids have also been used as good
emulsifiers especially in combination with surfactants and in
viscous preparations. These include polar inorganic solids, such as
heavy metal hydroxides, nonswelling clays such as bentonite,
attapulgite, hectorite, kaolin, montmorillonite, colloidal aluminum
silicate and colloidal magnesium aluminum silicate, pigments and
nonpolar solids such as carbon or glyceryl tristearate.
[0120] A large variety of non-emulsifying materials are also
included in emulsion formulations and contribute to the properties
of emulsions. These include fats, oils, waxes, fatty acids, fatty
alcohols, fatty esters, humectants, hydrophilic colloids,
preservatives and antioxidants (Block, in Pharmaceutical Dosage
Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker,
Inc., New York, N.Y., volume 1, p. 335; Idson, in Pharmaceutical
Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel
Dekker, Inc., New York, N.Y., volume 1, p. 199).
[0121] Hydrophilic colloids or hydrocolloids include naturally
occurring gums and synthetic polymers such as polysaccharides (for
example, acacia, agar, alginic acid, carrageenan, guar gum, karaya
gum, and tragacanth), cellulose derivatives (for example,
carboxymethylcellulose and carboxypropylcellulose), and synthetic
polymers (for example, carbomers, cellulose ethers, and
carboxyvinyl polymers). These disperse or swell in water to form
colloidal solutions that stabilize emulsions by forming strong
interfacial films around the dispersed-phase droplets and by
increasing the viscosity of the external phase.
[0122] Since emulsions often contain a number of ingredients such
as carbohydrates, proteins, sterols and phosphatides that may
readily support the growth of microbes, these formulations often
incorporate preservatives. Commonly used preservatives included in
emulsion formulations include methyl paraben, propyl paraben,
quaternary ammonium salts, benzalkonium chloride, esters of
p-hydroxybenzoic acid, and boric acid. Antioxidants are also
commonly added to emulsion formulations to prevent deterioration of
the formulation. Antioxidants used may be free radical scavengers
such as tocopherols, alkyl gallates, butylated hydroxyanisole,
butylated hydroxytoluene, or reducing agents such as ascorbic acid
and sodium metabisulfite, and antioxidant synergists such as citric
acid, tartaric acid, and lecithin.
[0123] The application of emulsion formulations via dermatological,
oral and parenteral routes and methods for their manufacture have
been reviewed in the literature (Idson, in Pharmaceutical Dosage
Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker,
Inc., New York, N.Y., volume 1, p. 199). Emulsion formulations for
oral delivery have been very widely used because of ease of
formulation, as well as efficacy from an absorption and
bioavailability standpoint (Rosoff, in Pharmaceutical Dosage Forms,
Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New
York, N.Y., volume 1, p. 245; Idson, in Pharmaceutical Dosage
Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker,
Inc., New York, N.Y., volume 1, p. 199). Mineral-oil base
laxatives, oil-soluble vitamins and high fat nutritive preparations
are among the materials that have commonly been administered orally
as o/w emulsions.
[0124] In one embodiment of the present invention, the compositions
of dsRNAs and nucleic acids are formulated as microemulsions. A
microemulsion may be defined as a system of water, oil and
amphiphile which is a single optically isotropic and
thermodynamically stable liquid solution (Rosoff, in Pharmaceutical
Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel
Dekker, Inc., New York, N.Y., volume 1, p. 245). Typically
microemulsions are systems that are prepared by first dispersing an
oil in an aqueous surfactant solution and then adding a sufficient
amount of a fourth component, generally an intermediate
chain-length alcohol to form a transparent system. Therefore,
microemulsions have also been described as thermodynamically
stable, isotropically clear dispersions of two immiscible liquids
that are stabilized by interfacial films of surface-active
molecules (Leung and Shah, in: Controlled Release of Drugs:
Polymers and Aggregate Systems, Rosoff, M., Ed., 1989, VCH
Publishers, New York, pages 185-215). Microemulsions commonly are
prepared via a combination of three to five components that include
oil, water, surfactant, cosurfactant and electrolyte. Whether the
microemulsion is of the water-in-oil (w/o) or an oil-in-water (o/w)
type is dependent on the properties of the oil and surfactant used
and on the structure and geometric packing of the polar heads and
hydrocarbon tails of the surfactant molecules (Schott, in
Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton,
Pa., 1985, p. 271).
[0125] The phenomenological approach utilizing phase diagrams has
been extensively studied and has yielded a comprehensive knowledge,
to one skilled in the art, of how to formulate microemulsions
(Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and
Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1,
p. 245; Block, in Pharmaceutical Dosage Forms, Lieberman, Rieger
and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y.,
volume 1, p. 335). Compared to conventional emulsions,
microemulsions offer the advantage of solubilizing water-insoluble
drugs in a formulation of thermodynamically stable droplets that
are formed spontaneously.
[0126] Surfactants used in the preparation of microemulsions
include, but are not limited to, ionic surfactants, non-ionic
surfactants, Brij 96, polyoxyethylene oleyl ethers, polyglycerol
fatty acid esters, tetraglycerol monolaurate (ML310), tetraglycerol
monooleate (MO310), hexaglycerol monooleate (PO.sub.310),
hexaglycerol pentaoleate (PO.sub.500), decaglycerol monocaprate
(MCA750), decaglycerol monooleate (MO750), decaglycerol sequioleate
(SO750), decaglycerol decaoleate (DA0750), alone or in combination
with cosurfactants. The cosurfactant, usually a short-chain alcohol
such as ethanol, 1-propanol, and 1-butanol, serves to increase the
interfacial fluidity by penetrating into the surfactant film and
consequently creating a disordered film because of the void space
generated among surfactant molecules. Microemulsions may, however,
be prepared without the use of cosurfactants and alcohol-free
self-emulsifying microemulsion systems are known in the art. The
aqueous phase may typically be, but is not limited to, water, an
aqueous solution of the drug, glycerol, PEG300, PEG400,
polyglycerols, propylene glycols, and derivatives of ethylene
glycol. The oil phase may include, but is not limited to, materials
such as Captex 300, Captex 355, Capmul MCM, fatty acid esters,
medium chain (C8-C12) mono, di, and tri-glycerides,
polyoxyethylated glyceryl fatty acid esters, fatty alcohols,
polyglycolized glycerides, saturated polyglycolized C8-C10
glycerides, vegetable oils and silicone oil.
[0127] Microemulsions are particularly of interest from the
standpoint of drug solubilization and the enhanced absorption of
drugs. Lipid based microemulsions (both o/w and w/o) have been
proposed to enhance the oral bioavailability of drugs, including
peptides (Constantinides et al., Pharmaceutical Research, 1994, 11,
1385-1390; Ritschel, Meth. Find. Exp. Clin. Pharmacol., 1993, 13,
205). Microemulsions afford advantages of improved drug
solubilization, protection of drug from enzymatic hydrolysis,
possible enhancement of drug absorption due to surfactant-induced
alterations in membrane fluidity and permeability, ease of
preparation, ease of oral administration over solid dosage forms,
improved clinical potency, and decreased toxicity (Constantinides
et al., Pharmaceutical Research, 1994, 11, 1385; Ho et al., J.
Pharm. Sci., 1996, 85, 138-143). Often microemulsions may form
spontaneously when their components are brought together at ambient
temperature. This may be particularly advantageous when formulating
thermolabile drugs, peptides or dsRNAs. Microemulsions have also
been effective in the transdermal delivery of active components in
both cosmetic and pharmaceutical applications. It is expected that
the microemulsion compositions and formulations of the present
invention will facilitate the increased systemic absorption of
dsRNAs and nucleic acids from the gastrointestinal tract, as well
as improve the local cellular uptake of dsRNAs and nucleic
acids.
[0128] Microemulsions of the present invention may also contain
additional components and additives such as sorbitan monostearate
(Grill 3), Labrasol, and penetration enhancers to improve the
properties of the formulation and to enhance the absorption of the
dsRNAs and nucleic acids of the present invention. Penetration
enhancers used in the microemulsions of the present invention may
be classified as belonging to one of five broad
categories--surfactants, fatty acids, bile salts, chelating agents,
and non-chelating non-surfactants (Lee et al., Critical Reviews in
Therapeutic Drug Carrier Systems, 1991, p. 92). Each of these
classes has been discussed above.
[0129] Liposomal Formulations
[0130] There are many organized surfactant structures besides
microemulsions that have been studied and used for the formulation
of drugs. These include monolayers, micelles, bilayers and
vesicles. Vesicles, such as liposomes, have attracted great
interest because of their specificity and the duration of action
they offer from the standpoint of drug delivery. As used in the
present invention, the term "liposome" means a vesicle composed of
amphiphilic lipids arranged in a spherical bilayer or bilayers.
[0131] Liposomes are unilamellar or multilamellar vesicles which
have a membrane formed from a lipophilic material and an aqueous
interior. The aqueous portion contains the composition to be
delivered. Cationic liposomes possess the advantage of being able
to fuse to the cell wall. Non-cationic liposomes, although not able
to fuse as efficiently with the cell wall, are taken up by
macrophages in vivo.
[0132] In order to cross intact mammalian skin, lipid vesicles must
pass through a series of fine pores, each with a diameter less than
50 nm, under the influence of a suitable transdermal gradient.
Therefore, it is desirable to use a liposome which is highly
deformable and able to pass through such fine pores.
[0133] Further advantages of liposomes include; liposomes obtained
from natural phospholipids are biocompatible and biodegradable;
liposomes can incorporate a wide range of water and lipid soluble
drugs; liposomes can protect encapsulated drugs in their internal
compartments from metabolism and degradation (Rosoff, in
Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.),
1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245).
Important considerations in the preparation of liposome
formulations are the lipid surface charge, vesicle size and the
aqueous volume of the liposomes.
[0134] Liposomes are useful for the transfer and delivery of active
ingredients to the site of action. Because the liposomal membrane
is structurally similar to biological membranes, when liposomes are
applied to a tissue, the liposomes start to merge with the cellular
membranes and as the merging of the liposome and cell progresses,
the liposomal contents are emptied into the cell where the active
agent may act.
[0135] Liposomal formulations have been the focus of extensive
investigation as the mode of delivery for many drugs. There is
growing evidence that for topical administration, liposomes present
several advantages over other formulations. Such advantages include
reduced side-effects related to high systemic absorption of the
administered drug, increased accumulation of the administered drug
at the desired target, and the ability to administer a wide variety
of drugs, both hydrophilic and hydrophobic, into the skin.
[0136] Several reports have detailed the ability of liposomes to
deliver agents including high-molecular weight DNA into the skin.
Compounds including analgesics, antibodies, hormones and
high-molecular weight DNAs have been administered to the skin. The
majority of applications resulted in the targeting of the upper
epidermis
[0137] Liposomes fall into two broad classes. Cationic liposomes
are positively charged liposomes which interact with the negatively
charged DNA molecules to form a stable complex. The positively
charged DNA/liposome complex binds to the negatively charged cell
surface and is internalized in an endosome. Due to the acidic pH
within the endosome, the liposomes are ruptured, releasing their
contents into the cell cytoplasm (Wang et al., Biochem. Biophys.
Res. Commun., 1987, 147, 980-985).
[0138] Liposomes which are pH-sensitive or negatively-charged,
entrap DNA rather than complex with it. Since both the DNA and the
lipid are similarly charged, repulsion rather than complex
formation occurs. Nevertheless, some DNA is entrapped within the
aqueous interior of these liposomes. pH-sensitive liposomes have
been used to deliver DNA encoding the thymidine kinase gene to cell
monolayers in culture. Expression of the exogenous gene was
detected in the target cells (Zhou et al., Journal of Controlled
Release, 1992, 19, 269-274).
[0139] One major type of liposomal composition includes
phospholipids other than naturally-derived phosphatidylcholine.
Neutral liposome compositions, for example, can be formed from
dimyristoyl phosphatidylcholine (DMPC) or dipalmitoyl
phosphatidylcholine (DPPC). Anionic liposome compositions generally
are formed from dimyristoyl phosphatidylglycerol, while anionic
fusogenic liposomes are formed primarily from dioleoyl
phosphatidylethanolamine (DOPE). Another type of liposomal
composition is formed from phosphatidylcholine (PC) such as, for
example, soybean PC, and egg PC. Another type is formed from
mixtures of phospholipid and/or phosphatidylcholine and/or
cholesterol.
[0140] Several studies have assessed the topical delivery of
liposomal drug formulations to the skin. Application of liposomes
containing interferon to guinea pig skin resulted in a reduction of
skin herpes sores while delivery of interferon via other means
(e.g., as a solution or as an emulsion) were ineffective (Weiner et
al., Journal of Drug Targeting, 1992, 2, 405-410). Further, an
additional study tested the efficacy of interferon administered as
part of a liposomal formulation to the administration of interferon
using an aqueous system, and concluded that the liposomal
formulation was superior to aqueous administration (du Plessis et
al., Antiviral Research, 1992, 18, 259-265).
[0141] Non-ionic liposomal systems have also been examined to
determine their utility in the delivery of drugs to the skin, in
particular systems comprising non-ionic surfactant and cholesterol.
Non-ionic liposomal formulations comprising Novasome.TM. I
(glyceryl dilaurate/cholesterol/po-lyoxyethylene-10-stearyl ether)
and Novasome.TM. II (glyceryl
distearate/cholesterol/polyoxyethylene-10-stearyl ether) were used
to deliver cyclosporin-A into the dermis of mouse skin. Results
indicated that such non-ionic liposomal systems were effective in
facilitating the deposition of cyclosporin-A into different layers
of the skin (Hu et al. S.T.P.Pharma. Sci., 1994, 4, 6, 466).
[0142] Liposomes also include "sterically stabilized" liposomes, a
term which, as used herein, refers to liposomes comprising one or
more specialized lipids that, when incorporated into liposomes,
result in enhanced circulation lifetimes relative to liposomes
lacking such specialized lipids. Examples of sterically stabilized
liposomes are those in which part of the vesicle-forming lipid
portion of the liposome (A) comprises one or more glycolipids, such
as monosialoganglioside G.sub.M1, or (B) is derivatized with one or
more hydrophilic polymers, such as a polyethylene glycol (PEG)
moiety. While not wishing to be bound by any particular theory, it
is thought in the art that, at least for sterically stabilized
liposomes containing gangliosides, sphingomyelin, or
PEG-derivatized lipids, the enhanced circulation half-life of these
sterically stabilized liposomes derives from a reduced uptake into
cells of the reticuloendothelial system (RES) (Allen et al., FEBS
Letters, 1987, 223, 42; Wu et al., Cancer Research, 1993, 53,
3765).
[0143] Various liposomes comprising one or more glycolipids are
known in the art. Papahadjopoulos et al. (Ann. N.Y. Acad. Sci.,
1987, 507, 64) reported the ability of monosialoganglioside
G.sub.M1, galactocerebroside sulfate and phosphatidylinositol to
improve blood half-lives of liposomes. These findings were
expounded upon by Gabizon et al. (Proc. Natl. Acad. Sci. U.S.A.,
1988, 85, 6949). U.S. Pat. No. 4,837,028 and WO 88/04924, both to
Allen et al., disclose liposomes comprising (1) sphingomyelin and
(2) the ganglioside G.sub.M1 or a galactocerebroside sulfate ester.
U.S. Pat. No. 5,543,152 (Webb et al.) discloses liposomes
comprising sphingomyelin. Liposomes comprising
1,2-sn-dimyristoylphosphat-idylcholine are disclosed in WO 97/13499
(Lim et al).
[0144] Many liposomes comprising lipids derivatized with one or
more hydrophilic polymers, and methods of preparation thereof, are
known in the art. Sunamoto et al. (Bull. Chem. Soc. Jpn., 1980, 53,
2778) described liposomes comprising a nonionic detergent,
2C.sub.1215G, that contains a PEG moiety. Illum et al. (FEBS Lett.,
1984, 167, 79) noted that hydrophilic coating of polystyrene
particles with polymeric glycols results in significantly enhanced
blood half-lives. Synthetic phospholipids modified by the
attachment of carboxylic groups of polyalkylene glycols (e.g., PEG)
are described by Sears (U.S. Pat. Nos. 4,426,330 and 4,534,899).
Klibanov et al. (FEBS Lett., 1990, 268, 235) described experiments
demonstrating that liposomes comprising phosphatidylethanolamine
(PE) derivatized with PEG or PEG stearate have significant
increases in blood circulation half-lives. Blume et al. (Biochimica
et Biophysica Acta, 1990, 1029, 91) extended such observations to
other PEG-derivatized phospholipids, e.g., DSPE-PEG, formed from
the combination of distearoylphosphatidylethanolamine (DSPE) and
PEG. Liposomes having covalently bound PEG moieties on their
external surface are described in European Patent No. EP 0 445 131
B1 and WO 90/04384 to Fisher. Liposome compositions containing 1-20
mole percent of PE derivatized with PEG, and methods of use
thereof, are described by Woodle et al. (U.S. Pat. Nos. 5,013,556
and 5,356,633) and Martin et al. (U.S. Pat. No. 5,213,804 and
European Patent No. EP 0 496 813 B1). Liposomes comprising a number
of other lipid-polymer conjugates are disclosed in WO 91/05545 and
U.S. Pat. No. 5,225,212 (both to Martin et al.) and in WO 94/20073
(Zalipsky et al.) Liposomes comprising PEG-modified ceramide lipids
are described in WO 96/10391 (Choi et al). U.S. Pat. No. 5,540,935
(Miyazaki et al.) and U.S. Pat. No. 5,556,948 (Tagawa et al.)
describe PEG-containing liposomes that can be further derivatized
with functional moieties on their surfaces.
[0145] A number of liposomes comprising nucleic acids are known in
the art. WO 96/40062 to Thierry et al. discloses methods for
encapsulating high molecular weight nucleic acids in liposomes.
U.S. Pat. No. 5,264,221 to Tagawa et al. discloses protein-bonded
liposomes and asserts that the contents of such liposomes may
include a dsRNA. U.S. Pat. No. 5,665,710 to Rahman et al. describes
certain methods of encapsulating oligodeoxynucleotides in
liposomes. WO 97/04787 to Love et al. discloses liposomes
comprising dsRNAs targeted to the raf gene.
[0146] Transfersomes are yet another type of liposomes, and are
highly deformable lipid aggregates which are attractive candidates
for drug delivery vehicles. Transfersomes may be described as lipid
droplets which are so highly deformable that they are easily able
to penetrate through pores which are smaller than the droplet.
Transfersomes are adaptable to the environment in which they are
used, e.g., they are self-optimizing (adaptive to the shape of
pores in the skin), self-repairing, frequently reach their targets
without fragmenting, and often self-loading. To make transfersomes
it is possible to add surface edge-activators, usually surfactants,
to a standard liposomal composition. Transfersomes have been used
to deliver serum albumin to the skin. The transfersome-mediated
delivery of serum albumin has been shown to be as effective as
subcutaneous injection of a solution containing serum albumin.
[0147] Surfactants find wide application in formulations such as
emulsions (including microemulsions) and liposomes. The most common
way of classifying and ranking the properties of the many different
types of surfactants, both natural and synthetic, is by the use of
the hydrophile/lipophile balance (HLB). The nature of the
hydrophilic group (also known as the "head") provides the most
useful means for categorizing the different surfactants used in
formulations (Rieger, in Pharmaceutical Dosage Forms, Marcel
Dekker, Inc., New York, N.Y., 1988, p. 285).
[0148] If the surfactant molecule is not ionized, it is classified
as a nonionic surfactant. Nonionic surfactants find wide
application in pharmaceutical and cosmetic products and are usable
over a wide range of pH values. In general their HLB values range
from 2 to about 18 depending on their structure. Nonionic
surfactants include nonionic esters such as ethylene glycol esters,
propylene glycol esters, glyceryl esters, polyglyceryl esters,
sorbitan esters, sucrose esters, and ethoxylated esters. Nonionic
alkanolamides and ethers such as fatty alcohol ethoxylates,
propoxylated alcohols, and ethoxylated/propoxylated block polymers
are also included in this class. The polyoxyethylene surfactants
are the most popular members of the nonionic surfactant class.
[0149] If the surfactant molecule carries a negative charge when it
is dissolved or dispersed in water, the surfactant is classified as
anionic. Anionic surfactants include carboxylates such as soaps,
acyl lactylates, acyl amides of amino acids, esters of sulfuric
acid such as alkyl sulfates and ethoxylated alkyl sulfates,
sulfonates such as alkyl benzene sulfonates, acyl isethionates,
acyl taurates and sulfosuccinates, and phosphates. The most
important members of the anionic surfactant class are the alkyl
sulfates and the soaps.
[0150] If the surfactant molecule carries a positive charge when it
is dissolved or dispersed in water, the surfactant is classified as
cationic. Cationic surfactants include quaternary ammonium salts
and ethoxylated amines. The quaternary ammonium salts are the most
used members of this class.
[0151] If the surfactant molecule has the ability to carry either a
positive or negative charge, the surfactant is classified as
amphoteric. Amphoteric surfactants include acrylic acid
derivatives, substituted alkylamides, N-alkylbetaines and
phosphatides.
[0152] The use of surfactants in drug products, formulations and in
emulsions has been reviewed (Rieger, in Pharmaceutical Dosage
Forms, Marcel Dekker, Inc., New York, N.Y., 1988, p. 285).
[0153] Nucleic Acid Lipid Particles
[0154] In one embodiment, a dsRNA featured in the invention is
fully encapsulated in the lipid formulation to form a SPLP, pSPLP,
SNALP, or other nucleic acid-lipid particle. As used herein, the
term "SNALP" refers to a stable nucleic acid-lipid particle,
including SPLP. As used herein, the term "SPLP" refers to a nucleic
acid-lipid particle comprising plasmid DNA encapsulated within a
lipid vesicle. SNALPs and SPLPs typically contain a cationic lipid,
a non-cationic lipid, and a lipid that prevents aggregation of the
particle (e.g., a PEG-lipid conjugate). SNALPs and SPLPs are
extremely useful for systemic applications, as they exhibit
extended circulation lifetimes following intravenous (i.v.)
injection and accumulate at distal sites (e.g., sites physically
separated from the administration site). SPLPs include "pSPLP,"
which include an encapsulated condensing agent-nucleic acid complex
as set forth in PCT Publication No. WO 00/03683. The particles of
the present invention typically have a mean diameter of about 50 nm
to about 150 nm, more typically about 60 nm to about 130 nm, more
typically about 70 nm to about 110 nm, most typically about 70 to
about 90 nm, and are substantially nontoxic. In addition, the
nucleic acids when present in the nucleic acid-lipid particles of
the present invention are resistant in aqueous solution to
degradation with a nuclease. Nucleic acid-lipid particles and their
method of preparation are disclosed in, e.g., U.S. Pat. Nos.
5,976,567; 5,981,501; 6,534,484; 6,586,410; 6,815,432; and PCT
Publication No. WO 96/40964.
[0155] In one embodiment, the lipid to drug ratio (mass/mass ratio)
(e.g., lipid to dsRNA ratio) will be in the range of from about 1:1
to about 50:1, from about 1:1 to about 25:1, from about 3:1 to
about 15:1, from about 4:1 to about 10:1, from about 5:1 to about
9:1, or about 6:1 to about 9:1.
[0156] The cationic lipid may be, for example,
N,N-dioleyl-N,N-dimethylammonium chloride (DODAC),
N,N-distearyl-N,N-dimethylammonium bromide (DDAB),
N-(1-(2,3-dioleoyloxy)propyl)-N,N,N-trimethylammonium chloride
(DOTAP), N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium
chloride (DOTMA), N,N-dimethyl-2,3-dioleyloxy)propylamine (DODMA),
1,2-DiLinoleyloxy-N,N-dimethylaminopropane (DLinDMA),
1,2-Dilinolenyloxy-N,N-dimethylaminopropane (DLenDMA),
1,2-Dilinoleylcarbamoyloxy-3-dimethylaminopropane (DLin-C-DAP),
1,2-Dilinoleyoxy-3-(dimethylamino)acetoxypropane (DLin-DAC),
1,2-Dilinoleyoxy-3-morpholinopropane (DLin-MA),
1,2-Dilinoleoyl-3-dimethylaminopropane (DLinDAP),
1,2-Dilinoleylthio-3-dimethylaminopropane (DLin-S-DMA),
1-Linoleoyl-2-linoleyloxy-3-dimethylaminopropane (DLin-2-DMAP),
1,2-Dilinoleyloxy-3-trimethylaminopropane chloride salt
(DLin-TMA.Cl), 1,2-Dilinoleoyl-3-trimethylaminopropane chloride
salt (DLin-TAP.Cl), 1,2-Dilinoleyloxy-3-(N-methylpiperazino)propane
(DLin-MPZ), or 3-(N,N-Dilinoleylamino)-1,2-propanediol (DLinAP),
3-(N,N-Dioleylamino)-1,2-propanedio (DOAP),
1,2-Dilinoleyloxo-3-(2-N,N-dimethylamino)ethoxypropane
(DLin-EG-DMA), 2,2-Dilinoleyl-4-dimethylaminomethyl-[1,3]-dioxolane
(DLin-K-DMA) or analogs thereof, or a mixture thereof. The cationic
lipid may comprise from about 20 mol % to about 50 mol % or about
40 mol % of the total lipid present in the particle.
[0157] In another embodiment, the compound
2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane can be used to
prepare lipid-siRNA nanoparticles. Synthesis of
2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane is described in
U.S. provisional patent application No. 61/107,998 filed on Oct.
23, 2008, which is herein incorporated by reference.
[0158] In one embodiment, the lipid-siRNA particle includes 40%
2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane: 10% DSPC: 40%
Cholesterol: 10% PEG-C-DOMG (mole percent) with a particle size of
63.0.+-.20 nm and a 0.027 siRNA/Lipid Ratio.
[0159] The non-cationic lipid may be an anionic lipid or a neutral
lipid including, but not limited to, distearoylphosphatidylcholine
(DSPC), dioleoylphosphatidylcholine (DOPC),
dipalmitoylphosphatidylcholine (DPPC), dioleoylphosphatidylglycerol
(DOPG), dipalmitoylphosphatidylglycerol (DPPG),
dioleoyl-phosphatidylethanolamine (DOPE),
palmitoyloleoylphosphatidylcholine (POPC),
palmitoyloleoyl-phosphatidylethanolamine (POPE),
dioleoyl-phosphatidylethanolamine
4-(N-maleimidomethyl)-cyclohexane-1-carboxylate (DOPE-mal),
dipalmitoyl phosphatidyl ethanolamine (DPPE),
dimyristoylphosphoethanolamine (DMPE),
distearoyl-phosphatidyl-ethanolamine (DSPE), 16-O-monomethyl PE,
16-O-dimethyl PE, 18-1-trans PE,
1-stearoyl-2-oleoyl-phosphatidyethanolamine (SOPE), cholesterol, or
a mixture thereof. The non-cationic lipid may be from about 5 mol %
to about 90 mol %, about 10 mol %, or about 58 mol % if cholesterol
is included, of the total lipid present in the particle.
[0160] The conjugated lipid that inhibits aggregation of particles
may be, for example, a polyethyleneglycol (PEG)-lipid including,
without limitation, a PEG-diacylglycerol (DAG), a
PEG-dialkyloxypropyl (DAA), a PEG-phospholipid, a PEG-ceramide
(Cer), or a mixture thereof. The PEG-DAA conjugate may be, for
example, a PEG-dilauryloxypropyl (Ci.sub.2), a
PEG-dimyristyloxypropyl (Ci.sub.4), a PEG-dipalmityloxypropyl
(Ci.sub.6), or a PEG-distearyloxypropyl (C].sub.8). The conjugated
lipid that prevents aggregation of particles may be from 0 mol % to
about 20 mol % or about 2 mol % of the total lipid present in the
particle.
[0161] In some embodiments, the nucleic acid-lipid particle further
includes cholesterol at, e.g., about 10 mol % to about 60 mol % or
about 48 mol % of the total lipid present in the particle.
[0162] LNP01
[0163] In one embodiment, the lipidoid ND98.4HCl (MW 1487) (Formula
I), Cholesterol (Sigma-Aldrich), and PEG-Ceramide C16 (Avanti Polar
Lipids) can be used to prepare lipid-siRNA nanoparticles (i.e.,
LNP01 particles). Stock solutions of each in ethanol can be
prepared as follows: ND98, 133 mg/ml; Cholesterol, 25 mg/ml,
PEG-Ceramide C16, 100 mg/ml. The ND98, Cholesterol, and
PEG-Ceramide C16 stock solutions can then be combined in a, e.g.,
42:48:10 molar ratio. The combined lipid solution can be mixed with
aqueous siRNA (e.g., in sodium acetate pH 5) such that the final
ethanol concentration is about 35-45% and the final sodium acetate
concentration is about 100-300 mM. Lipid-siRNA nanoparticles
typically form spontaneously upon mixing. Depending on the desired
particle size distribution, the resultant nanoparticle mixture can
be extruded through a polycarbonate membrane (e.g., 100 nm cut-off)
using, for example, a thermobarrel extruder, such as Lipex Extruder
(Northern Lipids, Inc). In some cases, the extrusion step can be
omitted. Ethanol removal and simultaneous buffer exchange can be
accomplished by, for example, dialysis or tangential flow
filtration. Buffer can be exchanged with, for example, phosphate
buffered saline (PBS) at about pH 7, e.g., about pH 6.9, about pH
7.0, about pH 7.1, about pH 7.2, about pH 7.3, or about pH 7.4.
##STR00001##
[0164] LNP01 formulations are described, e.g., in International
Application Publication No. WO 2008/042973, which is hereby
incorporated by reference.
[0165] As mentioned above, the lipid-dsRNA particle can comprise a
cationic lipid, a neutral lipid, a steroid, and optionally a lipid
that prevents aggregation of the particle. The relative percentages
of these constitutents can vary depending on the type of lipids
used. However, in general, the cationic lipid comprises from about
20 mol % to about 70 mol % or about 40 mol % to about 60 mol % of
the total lipid present in the particle; neutral lipids comprise
from about 5 mol % to about 90 mol %, about 10 mol %, or about 58
mol % if cholesterol is included, of the total lipid present in the
particle; the steroid (typically cholesterol) can comprise from
about 10 mol % to about 60 mol % or about 48 mol % of the total
lipid present in the particle; finally, the lipid that prevents
aggregation of the particle, typically a conjugated lipid (e.g., a
PEG-conjugated lipid) can comprise from 0 mol % to about 20 mol %
or about 2 mol % of the total lipid present in the particle.
[0166] In one embodiment, the lipid-dsRNA particle includes 40 mol
% 2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane, 10 mol %
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 40 mol %
Cholesterol, 10 mol % PEG-C-DOMG with a particle size of 63.0.+-.20
nm and a 0.027 dsRNA/Lipid Ratio.
[0167] In another embodiment, the lipid-dsRNA particle includes 40
mol % 1,2-dilinoleyloxy-N,N-dimethyl-3-aminopropane (DLinDMA), 10
mol % 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 2 mol %
3-N--[(qmethoxypoly(ethylene
glycol)2000)carbamoyl]-1,2-dimyristyloxy-propylamine (PEG-C-DMA),
and 48 mol % cholesterol.
[0168] In another embodiment, the lipid-dsRNA particle includes
57.1 mol % 1,2-Dilinolenyloxy-N,N-dimethylaminopropane (DLinDMA),
7.1 mol % DPPC, 34.4 mol % Cholesterol, 1.4 mol % PEG-cDMA.
[0169] In another embodiment, the lipid-dsRNA particle includes 48
mol % cholesterol, 20 mol % of the neutral lipid
1,2-distearoyl-sn-glycero-3-phosphocholine, 2 mol % of PEG-cDMA
(3-N-[(methoxy poly(ethylene
glycol)2000)carbamoyl]-1,2-dimyrestyloxypropylamine), and 30 mol %
of the cationic lipid DLinDMA
(1,2-dilinoleyloxy-3-(N,N-dimethyl)aminopropane).
[0170] In another embodiment, the lipid-dsRNA particle includes 48
mol % cholesterol, 20 mol % of the neutral lipid
1,2-distearoyl-sn-glycero-3-phosphocholine, 2 mol % of PEG-cDMA
(3-N-[(methoxy poly(ethylene
glycol)2000)carbamoyl]-1,2-dimyrestyloxypropylamine), and 30 mol %
of the cationic lipid
2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane.
[0171] Additional exemplary lipid-siRNA formulations are as
follows:
TABLE-US-00001 cationic lipid/non-cationic
lipid//choleseterol/PEG-lipid conjugate Cationic Lipid Lipid:siRNA
ratio Process LNP05 2,2-Dilinoleyl-4- XTC/DSPC/Cholesterol/PEG-DMG
Extrusion dimethylaminoethyl- 57.5/7.5/31.5/3.5
[1,3]-dioxolane(XTC) lipid:siRNA~6:1 LNP06 2,2-Dilinoleyl-4-
XTC/DSPC/Cholesterol/PEG-DMG Extrusion dimethylaminoethyl-
57.5/7.5/31.5/3.5 [1,3]-dioxolane(XTC) lipid:siRNA~11:1 LNP07
2,2-Dilinoleyl-4- XTC/DSPC/Cholesterol/PEG-DMG In-line
dimethylaminoethyl- 60/7.5/31/1.5, mixing [1,3]-dioxolane(XTC)
lipid:siRNA~6:1 LNP08 2,2-Dilinoleyl-4-
XTC/DSPC/Cholesterol/PEG-DMG In-line dimethylaminoethyl-
60/7.5/31/1.5, mixing [1,3]-dioxolane(XTC) lipid:siRNA~11:1 LNP09
2,2-Dilinoleyl-4- XTC/DSPC/Cholesterol/PEG-DMG In-line
dimethylaminoethyl- 50/10/38.5/1.5 mixing [1,3]-dioxolane(XTC)
Lipid:siRNA 10:1 SNALP 1,2-Dilinolenyloxy-
DLinDMA/DPPC/Cholesterol/PEG-cDMA N,N- (57.1/7.1/34.4/1.4)
dimethylaminopropane lipid:siRNA~7:1 (DLinDMA) SNALP-
2,2-Dilinoleyl-4- XTC/DPPC/Cholesterol/PEG-cDMA XTC
dimethylaminoethyl- 57.1/7.1/34.4/1.4 [1,3]-dioxolane(XTC)
lipid:siRNA~7:1
[0172] Characterization of Lipid Formulated dsRNAs
[0173] Formulations prepared by either the in-line mixing or
extrusion-free method can be characterized in similar manners. For
example, formulations are typically characterized by visual
inspection. They should be whitish translucent solutions free from
aggregates or sediment. Particle size and particle size
distribution of lipid-nanoparticles can be measured by light
scattering using, for example, a Malvern Zetasizer Nano ZS
(Malvern, USA). Particles should be about 20-300 nm, such as 40-100
nm in size. The particle size distribution should be unimodal. The
total siRNA concentration in the formulation, as well as the
entrapped fraction, is estimated using a dye exclusion assay. A
sample of the formulated siRNA can be incubated with an RNA-binding
dye, such as Ribogreen (Molecular Probes) in the presence or
absence of a formulation disrupting surfactant, e.g., 0.5%
Triton-X100. The total siRNA in the formulation can be determined
by the signal from the sample containing the surfactant, relative
to a standard curve. The entrapped fraction is determined by
subtracting the "free" siRNA content (as measured by the signal in
the absence of surfactant) from the total siRNA content. Percent
entrapped siRNA is typically >85%. For SNALP formulation, the
particle size is at least 30 nm, at least 40 nm, at least 50 nm, at
least 60 nm, at least 70 nm, at least 80 nm, at least 90 nm, at
least 100 nm, at least 110 nm, and at least 120 nm. The suitable
range is typically about at least 50 nm to about at least 110 nm,
about at least 60 nm to about at least 100 nm, or about at least 80
nm to about at least 90 nm.
[0174] Penetration Enhancers
[0175] In one embodiment, the present invention employs various
penetration enhancers to effect the efficient delivery of nucleic
acids, particularly dsRNAs, to the skin of animals. Most drugs are
present in solution in both ionized and nonionized forms. However,
usually only lipid soluble or lipophilic drugs readily cross cell
membranes. It has been discovered that even non-lipophilic drugs
may cross cell membranes if the membrane to be crossed is treated
with a penetration enhancer. In addition to aiding the diffusion of
non-lipophilic drugs across cell membranes, penetration enhancers
also enhance the permeability of lipophilic drugs.
[0176] Penetration enhancers may be classified as belonging to one
of five broad categories, i.e., surfactants, fatty acids, bile
salts, chelating agents, and non-chelating non-surfactants (Lee et
al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p.
92). Each of the above mentioned classes of penetration enhancers
are described below in greater detail.
[0177] Surfactants: In connection with the present invention,
surfactants (or "surface-active agents") are chemical entities
which, when dissolved in an aqueous solution, reduce the surface
tension of the solution or the interfacial tension between the
aqueous solution and another liquid, with the result that
absorption of dsRNAs through the mucosa is enhanced. In addition to
bile salts and fatty acids, these penetration enhancers include,
for example, sodium lauryl sulfate, polyoxyethylene-9-lauryl ether
and polyoxyethylene-20-cetyl ether) (Lee et al., Critical Reviews
in Therapeutic Drug Carrier Systems, 1991, p. 92); and
perfluorochemical emulsions, such as FC-43. Takahashi et al., J.
Pharm. Pharmacol., 1988, 40, 252).
[0178] Fatty acids: Various fatty acids and their derivatives which
act as penetration enhancers include, for example, oleic acid,
lauric acid, capric acid (n-decanoic acid), myristic acid, palmitic
acid, stearic acid, linoleic acid, linolenic acid, dicaprate,
tricaprate, monoolein (1-monooleoyl-rac-glycerol), dilaurin,
caprylic acid, arachidonic acid, glycerol 1-monocaprate,
1-dodecylazacycloheptan-2-one, acylcarnitines, acylcholines,
C.sub.1-10 alkyl esters thereof (e.g., methyl, isopropyl and
t-butyl), and mono- and di-glycerides thereof (i.e., oleate,
laurate, caprate, myristate, palmitate, stearate, linoleate, etc.)
(Lee et al., Critical Reviews in Therapeutic Drug Carryier Systems,
1991, p. 92; Muranishi, Critical Reviews in Therapeutic Drug
Carrier Systems, 1990, 7, 1-33; El Hariri et al., J. Pharm.
Pharmacol., 1992, 44, 651-654).
[0179] Bile salts: The physiological role of bile includes the
facilitation of dispersion and absorption of lipids and fat-soluble
vitamins (Brunton, Chapter 38 in: Goodman & Gilman's The
Pharmacological Basis of Therapeutics, 9th Ed., Hardman et al.
Eds., McGraw-Hill, New York, 1996, pp. 934-935). Various natural
bile salts, and their synthetic derivatives, act as penetration
enhancers. Thus the term "bile salts" includes any of the naturally
occurring components of bile as well as any of their synthetic
derivatives. The bile salts of the invention include, for example,
cholic acid (or its pharmaceutically acceptable sodium salt, sodium
cholate), dehydrocholic acid (sodium dehydrocholate), deoxycholic
acid (sodium deoxycholate), glucholic acid (sodium glucholate),
glycholic acid (sodium glycocholate), glycodeoxycholic acid (sodium
glycodeoxycholate), taurocholic acid (sodium taurocholate),
taurodeoxycholic acid (sodium taurodeoxycholate), chenodeoxycholic
acid (sodium chenodeoxycholate), ursodeoxycholic acid (UDCA),
sodium tauro-24,25-dihydro-fusidate (STDHF), sodium
glycodihydrofusidate and polyoxyethylene-9-lauryl ether (POE) (Lee
et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991,
page 92; Swinyard, Chapter 39 In: Remington's Pharmaceutical
Sciences, 18th Ed., Gennaro, ed., Mack Publishing Co., Easton, Pa.,
1990, pages 782-783; Muranishi, Critical Reviews in Therapeutic
Drug Carrier Systems, 1990, 7, 1-33; Yamamoto et al., J. Pharm.
Exp. Ther., 1992, 263, 25; Yamashita et al., J. Pharm. Sci., 1990,
79, 579-583).
[0180] Chelating Agents: Chelating agents, as used in connection
with the present invention, can be defined as compounds that remove
metallic ions from solution by forming complexes therewith, with
the result that absorption of dsRNAs through the mucosa is
enhanced. With regards to their use as penetration enhancers in the
present invention, chelating agents have the added advantage of
also serving as DNase inhibitors, as most characterized DNA
nucleases require a divalent metal ion for catalysis and are thus
inhibited by chelating agents (Jarrett, J. Chromatogr., 1993, 618,
315-339). Chelating agents of the invention include but are not
limited to disodium ethylenediaminetetraacetate (EDTA), citric
acid, salicylates (e.g., sodium salicylate, 5-methoxysalicylate and
homovanilate), N-acyl derivatives of collagen, laureth-9 and
N-amino acyl derivatives of beta-diketones (enamines) (Lee et al.,
Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page
92; Muranishi, Critical Reviews in Therapeutic Drug Carrier
Systems, 1990, 7, 1-33; Buur et al., J. Control Rel., 1990, 14,
43-51).
[0181] Non-chelating non-surfactants: As used herein, non-chelating
non-surfactant penetration enhancing compounds can be defined as
compounds that demonstrate insignificant activity as chelating
agents or as surfactants but that nonetheless enhance absorption of
dsRNAs through the alimentary mucosa (Muranishi, Critical Reviews
in Therapeutic Drug Carrier Systems, 1990, 7, 1-33). This class of
penetration enhancers include, for example, unsaturated cyclic
ureas, 1-alkyl- and 1-alkenylazacyclo-alkanone derivatives (Lee et
al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991,
page 92); and non-steroidal anti-inflammatory agents such as
diclofenac sodium, indomethacin and phenylbutazone (Yamashita et
al., J. Pharm. Pharmacol., 1987, 39, 621-626).
[0182] Agents that enhance uptake of dsRNAs at the cellular level
may also be added to the pharmaceutical and other compositions of
the present invention. For example, cationic lipids, such as
lipofectin (Junichi et al, U.S. Pat. No. 5,705,188), cationic
glycerol derivatives, and polycationic molecules, such as
polylysine (Lollo et al., PCT Application WO 97/30731), are also
known to enhance the cellular uptake of dsRNAs.
[0183] Other agents may be utilized to enhance the penetration of
the administered nucleic acids, including glycols such as ethylene
glycol and propylene glycol, pyrrols such as 2-pyrrol, azones, and
terpenes such as limonene and menthone.
[0184] Carriers
[0185] Certain compositions of the present invention also
incorporate carrier compounds in the formulation. As used herein,
"carrier compound" or "carrier" can refer to a nucleic acid, or
analog thereof, which is inert (i.e., does not possess biological
activity per se) but is recognized as a nucleic acid by in vivo
processes that reduce the bioavailability of a nucleic acid having
biological activity by, for example, degrading the biologically
active nucleic acid or promoting its removal from circulation. The
coadministration of a nucleic acid and a carrier compound,
typically with an excess of the latter substance, can result in a
substantial reduction of the amount of nucleic acid recovered in
the liver, kidney or other extracirculatory reservoirs, presumably
due to competition between the carrier compound and the nucleic
acid for a common receptor. For example, the recovery of a
partially phosphorothioate dsRNA in hepatic tissue can be reduced
when it is coadministered with polyinosinic acid, dextran sulfate,
polycytidic acid or 4-acetamido-4'
isothiocyano-stilbene-2,2'-disulfonic acid (Miyao et al., DsRNA
Res. Dev., 1995, 5, 115-121; Takakura et al., DsRNA & Nucl.
Acid Drug Dev., 1996, 6, 177-183.
[0186] Excipients
[0187] In contrast to a carrier compound, a "pharmaceutical
carrier" or "excipient" is a pharmaceutically acceptable solvent,
suspending agent or any other pharmacologically inert vehicle for
delivering one or more nucleic acids to an animal. The excipient
may be liquid or solid and is selected, with the planned manner of
administration in mind, so as to provide for the desired bulk,
consistency, etc., when combined with a nucleic acid and the other
components of a given pharmaceutical composition. Typical
pharmaceutical carriers include, but are not limited to, binding
agents (e.g., pregelatinized maize starch, polyvinylpyrrolidone or
hydroxypropyl methylcellulose, etc.); fillers (e.g., lactose and
other sugars, microcrystalline cellulose, pectin, gelatin, calcium
sulfate, ethyl cellulose, polyacrylates or calcium hydrogen
phosphate, etc.); lubricants (e.g., magnesium stearate, talc,
silica, colloidal silicon dioxide, stearic acid, metallic
stearates, hydrogenated vegetable oils, corn starch, polyethylene
glycols, sodium benzoate, sodium acetate, etc.); disintegrants
(e.g., starch, sodium starch glycolate, etc.); and wetting agents
(e.g., sodium lauryl sulphate, etc).
[0188] Pharmaceutically acceptable organic or inorganic excipient
suitable for non-parenteral administration which do not
deleteriously react with nucleic acids can also be used to
formulate the compositions of the present invention. Suitable
pharmaceutically acceptable carriers include, but are not limited
to, water, salt solutions, alcohols, polyethylene glycols, gelatin,
lactose, amylose, magnesium stearate, talc, silicic acid, viscous
paraffin, hydroxymethylcellulose, polyvinylpyrrolidone and the
like.
[0189] Formulations for topical administration of nucleic acids may
include sterile and non-sterile aqueous solutions, non-aqueous
solutions in common solvents such as alcohols, or solutions of the
nucleic acids in liquid or solid oil bases. The solutions may also
contain buffers, diluents and other suitable additives.
Pharmaceutically acceptable organic or inorganic excipients
suitable for non-parenteral administration which do not
deleteriously react with nucleic acids can be used.
[0190] Suitable pharmaceutically acceptable excipients include, but
are not limited to, water, salt solutions, alcohol, polyethylene
glycols, gelatin, lactose, amylose, magnesium stearate, talc,
silicic acid, viscous paraffin, hydroxymethylcellulose,
polyvinylpyrrolidone and the like.
[0191] Other Components
[0192] The compositions of the present invention may additionally
contain other adjunct components conventionally found in
pharmaceutical compositions, at their art-established usage levels.
Thus, for example, the compositions may contain additional,
compatible, pharmaceutically-active materials such as, for example,
antipruritics, astringents, local anesthetics or anti-inflammatory
agents, or may contain additional materials useful in physically
formulating various dosage forms of the compositions of the present
invention, such as dyes, flavoring agents, preservatives,
antioxidants, opacifiers, thickening agents and stabilizers.
However, such materials, when added, should not unduly interfere
with the biological activities of the components of the
compositions of the present invention. The formulations can be
sterilized and, if desired, mixed with auxiliary agents, e.g.,
lubricants, preservatives, stabilizers, wetting agents,
emulsifiers, salts for influencing osmotic pressure, buffers,
colorings, flavorings and/or aromatic substances and the like which
do not deleteriously interact with the nucleic acid(s) of the
formulation.
[0193] Aqueous suspensions may contain substances which increase
the viscosity of the suspension including, for example, sodium
carboxymethylcellulose, sorbitol and/or dextran. The suspension may
also contain stabilizers.
[0194] Certain embodiments of the invention provide pharmaceutical
compositions containing (a) one or more antisense compounds and (b)
one or more other chemotherapeutic agents which function by a
non-antisense mechanism. Examples of such chemotherapeutic agents
include but are not limited to daunorubicin, daunomycin,
dactinomycin, doxorubicin, epirubicin, idarubicin, esorubicin,
bleomycin, mafosfamide, ifosfamide, cytosine arabinoside,
bis-chloroethylnitrosurea, busulfan, mitomycin C, actinomycin D,
mithramycin, prednisone, hydroxyprogesterone, testosterone,
tamoxifen, dacarbazine, procarbazine, hexamethylmelamine,
pentamethylmelamine, mitoxantrone, amsacrine, chlorambucil,
methylcyclohexylnitrosurea, nitrogen mustards, melphalan,
cyclophosphamide, 6-mercaptopurine, 6-thioguanine, cytarabine,
5-azacytidine, hydroxyurea, deoxycoformycin,
4-hydroxyperoxycyclophosphor-amide, 5-fluorouracil (5-FU),
5-fluorodeoxyuridine (5-FUdR), methotrexate (MTX), colchicine,
taxol, vincristine, vinblastine, etoposide (VP-16), trimetrexate,
irinotecan, topotecan, gemcitabine, teniposide, cisplatin and
diethylstilbestrol (DES). See, generally, The Merck Manual of
Diagnosis and Therapy, 15th Ed. 1987, pp. 1206-1228, Berkow et al.,
eds., Rahway, N.J. When used with the compounds of the invention,
such chemotherapeutic agents may be used individually (e.g., 5-FU
and oligonucleotide), sequentially (e.g., 5-FU and oligonucleotide
for a period of time followed by MTX and oligonucleotide), or in
combination with one or more other such chemotherapeutic agents
(e.g., 5-FU, MTX and oligonucleotide, or 5-FU, radiotherapy and
oligonucleotide). Anti-inflammatory drugs, including but not
limited to nonsteroidal anti-inflammatory drugs and
corticosteroids, and antiviral drugs, including but not limited to
ribivirin, vidarabine, acyclovir and ganciclovir, may also be
combined in compositions of the invention. See, generally, The
Merck Manual of Diagnosis and Therapy, 15th Ed., Berkow et al.,
eds., 1987, Rahway, N.J., pages 2499-2506 and 46-49, respectively).
Other non-antisense chemotherapeutic agents are also within the
scope of this invention. Two or more combined compounds may be used
together or sequentially.
[0195] Toxicity and therapeutic efficacy of such compounds can be
determined by standard pharmaceutical procedures in cell cultures
or experimental animals, e.g., for determining the LD50 (the dose
lethal to 50% of the population) and the ED50 (the dose
therapeutically effective in 50% of the population). The dose ratio
between toxic and therapeutic effects is the therapeutic index and
it can be expressed as the ratio LD50/ED50. Compounds which exhibit
high therapeutic indices are preferred.
[0196] The data obtained from cell culture assays and animal
studies can be used in formulation a range of dosage for use in
humans. The dosage of compositions of the invention lies generally
within a range of circulating concentrations that include the ED50
with little or no toxicity. The dosage may vary within this range
depending upon the dosage form employed and the route of
administration utilized. For any compound used in the method of the
invention, the therapeutically effective dose can be estimated
initially from cell culture assays. A dose may be formulated in
animal models to achieve a circulating plasma concentration range
of the compound or, when appropriate, of the polypeptide product of
a target sequence (e.g., achieving a decreased concentration of the
polypeptide) that includes the IC50 (i.e., the concentration of the
test compound which achieves a half-maximal inhibition of symptoms)
as determined in cell culture. Such information can be used to more
accurately determine useful doses in humans. Levels in plasma may
be measured, for example, by high performance liquid
chromatography.
[0197] In addition to their administration, as discussed above, the
dsRNAs featured in the invention can be administered in combination
with other known agents effective in treatment of pathological
processes mediated by GSK-3 expression. In any event, the
administering physician can adjust the amount and timing of dsRNA
administration on the basis of results observed using standard
measures of efficacy known in the art or described herein.
[0198] Methods for Treating Diseases Caused by Expression of a
GSK-3 Gene
[0199] The invention relates in particular to the use of a dsRNA
targeting GSK-3 and compositions containing at least one such
dsRNA, for the treatment of a GSK-3-mediated disorder or disease.
For example, a dsRNA targeting a GSK-3 gene can be useful for the
treatment of manic depression.
[0200] Other disorders which can be treated with the compounds,
compositions and methods described herein include a metabolic
disease, such as metabolic disorders (e.g., Type I or Type II
diabetes or metabolic syndrome) and nervous system disorders,
(e.g., CNS or nuerogenerative disorders (e.g., Alzheimer's disease,
Parkinson's disease, Huntington's Disease, prion diseases (e.g.,
transmissible spongiform encephalopathies), stroke and
schizophrenia). Compositions and methods for treating pathological
conditions and diseases such as protozoan diseases (e.g.,
Plasmodium falciparum), cancer (e.g., colorectal cancer), and
circadian rhythm diseases (e.g., sleep disorders, jet lag, and
shift work), and are also provided. The dsRNAs described here can
also be used to regulate skeletal muscle growth, inflammatory
responses, platelet function, apoptosis, and cellular responses to
DNA damage.
[0201] "Metabolic syndrome" is characterized by a group of
metabolic risk factors including: abdominal obesity (excessive fat
tissue in and around the abdomen), atherogenic dyslipidemia (blood
fat disorders (including high triglycerides, low HDL cholesterol
and high LDL cholesterol) that foster plaque build-up in artery
walls), elevated blood pressure, insulin resistance or glucose
intolerance (due to the body's inability to properly use insulin or
blood sugar), a prothrombotic state (e.g., high fibrinogen or
plasminogen activator inhibitor-1 in the blood), and a
proinflammatory state (e.g., elevated C-reactive protein in the
blood). People with metabolic syndrome are at increased risk of
coronary heart disease and other diseases related to plaque
buildups in artery walls (e.g., stroke and peripheral vascular
disease), and Type II diabetes. Other metabolic diseases suitable
for treatment with a dsRNA targeting GSK-3 include obesity and
insulin resistance.
[0202] A dsRNA targeting GSK-3 can be also be useful for the
treatment of cancer, such as a colorectal cancer.
[0203] A composition containing a dsRNA targeting GSK-3 may also be
used to treat other tumors and cancers, such as breast cancer, lung
cancer, head and neck cancer, brain cancer, abdominal cancer, colon
cancer, colorectal cancer, esophagus cancer, gastrointestinal
cancer, glioma, tongue cancer, neuroblastoma, osteosarcoma, ovarian
cancer, pancreatic cancer, prostate cancer, retinoblastoma, Wilm's
tumor, multiple myeloma and for the treatment of skin cancer, like
melanoma, for the treatment of lymphomas and blood cancer.
[0204] Owing to the inhibitory effects on GSK-3 expression, a
composition according to the invention or a pharmaceutical
composition prepared therefrom can enhance the quality of life.
[0205] The invention further relates to the use of a dsRNA or a
pharmaceutical composition thereof, e.g., for treating manic
depression or another disorder described herein, in combination
with other pharmaceuticals and/or other therapeutic methods, e.g.,
with known pharmaceuticals and/or known therapeutic methods, such
as, for example, those which are currently employed for treating
these disorders.
[0206] For example, in the treatment of manic depression, the
patient can also be treated with one or more other therapeutic
modalities, e.g., lithium salts, anticonvulsant mood stabilizers,
antipsychotics, and other adjunctive treatments described herein.
In an embodiment the patient is also treated with lithium salts.
Lithium salts have been used as a first-line treatment for bipolar
disorder. Common lithium salts are lithium carbonate and (probably
less commonly) lithium citrate. Lithium orotate is used as an
alternative treatment to lithium carbonate by some individuals with
bipolar disorder. In an embodiment the patient is also treated with
an anticonvulsant mood stabilizer. Anticonvulsant medications,
particularly valproate and carbamazepine, have been used as
alternatives or adjuncts to lithium in many cases. Valproate
(Depakote, Epival) was FDA approved for the treatment of acute
mania in 1995, and is now considered by some doctors to be the
first line of therapy for bipolar disorder. A similar medication,
valproic acid (Depakene) is also used. Anticonvulsants are also
used in combination with antipsychotics. Newer anticonvulsant
medications, including lamotrigine and oxcarbazepine, are also
effective as mood stabilizers in bipolar disorder. Lamotrigine is
particularly promising, as it alleviates bipolar depression and
prevents recurrence at higher rates. Zonisamide (trade name
Zonegran), another anticonvulsant, also may show promise in
treating bipolar depression. Topiramate maybe useful for some
patients. It appears to be useful in some treatment resistant cases
and for anxiety issues when clonazepam cannot be prescribed. Other
anticonvulsants effective in some cases and under study include
phenyloin, levetiracetam, pregabalin and valnoctamide. In an
embodiment the patient is also treated with an "atypical
antipsychotic drug." The newer atypical antipsychotic drugs such as
risperidone, quetiapine, and olanzapine are often used in acutely
manic patients. In light of recent evidence, olanzapine (Zyprexa)
has been FDA approved as an effective monotherapy for the
maintenance of bipolar disorder. Eli Lilly and Company also offers
Symbyax, a combination of olanzapine and fluoxetine. Ziprasidone
(Geodon) and aripriprazole (Abilify) also show promise. Other newer
treatments include Modafinil (Provigil) and Pramipexole (Mirapex),
which show promise in treating the cognitive deterioration related
to bipolar depression. In addition Riluzole, an ALS treatment, has
been shown to be effective treatment. The breast cancer medicine
tamoxifen has shown quick response to manic phases. In an
embodiment the patient is also treated with electroconvulsive
therapy. Electroconvulsive therapy (ECT) is sometimes used to treat
severe bipolar depression in cases where other treatments have
failed and is 60 to 70 percent effective. In an embodiment the
patient is also treated with psychotherapy. Other treatments
include omega-3 fatty acids, particularly as a supplement to other
medication. There are also reports that medical marijuana can help
control the mood swings in some forms of bipolar disorder.
[0207] In an embodiment a dsRNA described herein is administered to
a patient who has previously been treated with another therapeutic
or counseling modality but which has provided less than optimal
results.
[0208] In the example of a metabolic disorder, e.g., diabetes, the
patient can also be provided administration of a dsRNA targeting
GSK-3 can be accompanied by a exercise regimen or by dietary
restrictions. A dsRNA featured in the invention can also be
administered with a drug or combination of drugs for managing Type
II diabetes, e.g., a sulfonylurea, a biguanide, an
alpha-glucosidase inhibitor, a thiazolidinedione, a meglitinide, a
D-phenylalanine derivative, an amylin synthetic derivatives, an
incretin mimetic, or an insulin. Exemplary insulins include regular
insulins (Humulin.RTM., Novolin.RTM.), insulin lispro
(Humalog.RTM.), insulin aspart (Novolog.RTM.), insulin glulisine
(Apidra.RTM.), prompt insulin zinc (Semilente.RTM., slightly slower
acting), inhaled insulin (Exubera.RTM.), intermediate-acting
insulins, isophane insulin, neutral protamine Hagedorn (NPH),
insulin zinc (Lente.RTM.), extended insulin zinc insulin
(Ultralente.RTM.), insulin glargine (Lantus.RTM.), and insulin
detemir (Levemir.RTM.).
[0209] In the example of cancerthe patient can also be provided
with a chemotherapy agent, such as deoxycoformycin, cisplatin,
cyclophosphamide, 5-fluorouracil, adriamycin, daunorubicin,
tamoxifen aunorubicin, daunomycin, dactinomycin, doxorubicin,
epirubicin, idarubicin, esorubicin, bleomycin, mafosfamide,
ifosfamide, cytosine arabinoside, bis-chloroethylnitrosurea,
busulfan, mitomycin C, actinomycin D, mithramycin, prednisone,
hydroxyprogesterone, testosterone, tamoxifen, dacarbazine,
procarbazine, hexamethylmelamine, pentamethylmelamine,
mitoxantrone, amsacrine, chlorambucil, methylcyclohexylnitrosurea,
nitrogen mustards, melphalan, cyclophosphamide, 6-mercaptopurine,
6-thioguanine, cytarabine, 5-azacytidine, hydroxyurea,
deoxycoformycin, 4-hydroxyperoxycyclophosphoramide, 5-fluorouracil
(5-FU), 5-fluorodeoxyuridine (5-FUdR), methotrexate (MTX),
colchicine, taxol, vincristine, vinblastine, etoposide (VP-16),
trimetrexate, irinotecan, topotecan, gemcitabine, teniposide,
cisplatin and diethylstilbestrol (DES). See, generally, The Merck
Manual of Diagnosis and Therapy, 15th Ed. 1987, pp. 1206-1228,
Berkow et al., eds., Rahway, N.J. When used with the dsRNAs
featured in the invention, such chemotherapeutic agents may be used
individually (e.g., deoxycoformycin and dsRNA), sequentially (e.g.,
antiviral and dsRNA for a period of time, followed by
deoxycoformycin and dsRNA), or in combination with one or more
other such agents (e.g., deoxycoformycin, antiviral and dsRNA, or
deoxycoformycin, radiotherapy and dsRNA). Two or more combined
compounds may be used together or sequentially.
[0210] Generally, the dsRNAs described here can be used in
combination with other GSK-3 inhibitors. Examples of such
inhibitors described in Meijer et al., Trends in Pharmacological
Sciences, 25: 471 (September 2004), incorporated herein by
reference include pyrroloazepines, (e.g., hymenialdisine), flavones
(e.g., flavopiridol), benzazepinones (e.g., kenpaullone,
alsterpaulione, and azakenpaullone), bis-indole indirubin-3'-oximes
(e.g., indirubin-3'-oxime, 6-bromoindirubin-3'-oxime (BIO), and
6-bromoindirubin-3'-acetoxime), pyrrolopyrazines (e.g., aloisine A
and aloisine B), thiadiazolidinones (e.g., TDZD8),
pyridyloxadiazoles (e.g., Compound 12), pyrazolopyridines (e.g.,
pyrazolopyridine 18 and pyrazolopyridine 34), pyrazolopyridazines
(e.g., pyrazolopyridine 9), aminopyrimidines (e.g., CHIR98014 and
CHIR99021 (CT99021)), pyrazoloquinoxalines (Compound 1), oxindoles
(indolinones) (e.g., SU9516), thiazoles (e.g., ARA014418),
bisindolylmaleimides (e.g., staurosporine and Compound 5a),
azaindolylmaleimides (e.g., Compound 29 and Compound 46),
bisindolylmaleimides (e.g., GF109203x (bisindolylmaleimide I) and
Ro318220 (bisindolylmaleimide IX)), arylindolemaleimides (e.g.,
SB216763), anilinomaleimides (e.g., SB415286),
anilinoarylmaleimides (e.g., IS), phenylaminopyrimidines (e.g.,
CGP60474), triazoles (e.g., Compound 8b), pyrrolopyrimidines (e.g.,
TWS119), pyrazolopyrimidines (e.g., Compound 1A), chloromethyl
thienyl ketone (e.g., Compound 17), atoms in competition with
Mg.sup.2+ (e.g., lithium), atoms in competition with Mg.sup.2+ and
ATP (e.g., beryllium), and uncompetitive atoms (e.g., zinc).
Structures for some of the inhibitors can be found in FIG. 2 of
Meijer et al. and are shown below.
##STR00002## ##STR00003## ##STR00004## ##STR00005## ##STR00006##
##STR00007##
Methods for Inhibiting Expression of the GSK-3 Gene
[0211] In yet another aspect, the invention provides a method for
inhibiting the expression of an GSK-3 gene in a mammal. The method
includes administering a composition featured in the invention to
the mammal such that expression of the target GSK-3 gene is
silenced.
[0212] When the organism to be treated is a mammal such as a human,
the composition may be administered by any means known in the art
including, but not limited to oral or parenteral routes, including
intravenous, intramuscular, subcutaneous, transdermal, airway
(aerosol), nasal, rectal, and topical (including buccal and
sublingual) administration. In preferred embodiments, the
compositions are administered by intravenous infusion or
injection.
[0213] Unless otherwise defined, all technical and scientific terms
used herein have the same meaning as commonly understood by one of
ordinary skill in the art to which this invention belongs. Although
methods and materials similar or equivalent to those described
herein can be used in the practice or testing of the invention,
suitable methods and materials are described below. All
publications, patent applications, patents, and other references
mentioned herein are incorporated by reference in their entirety.
In case of conflict, the present specification, including
definitions, will control. In addition, the materials, methods, and
examples are illustrative only and not intended to be limiting.
EXAMPLE
Example 1
Design and Synthesis of siRNA Targeting GSK3
[0214] siRNA Design for Mouse Glycogen Synthase Kinase 3 Alpha
(GSK3.alpha.)
[0215] All possible perfect match sense 19 mer oligomers were
extracted from mouse GSKalpha sequence NM.sub.--001031667.1, the
sole NCBI reference sequence for the mouse GSK3.alpha. gene, and
identified as candidate target regions. The sequences are shown in
Table 1 below.
[0216] In order to rank candidate target sequences and their
corresponding siRNAs and select appropriate ones, their predicted
potential for interacting with irrelevant targets (off-target
potential) was taken as the primary ranking parameter. siRNAs with
low off-target potential were defined as preferable and assumed to
be more specific in vivo.
[0217] To identify potential off-target genes, 19 mer candidate
sequences as well as their 19 mer reverse complements were
subjected to a homology search against the entire NCBI mouse
reference mRNA sequence collection using the FASTA search algorithm
(Pearson, W R, Lipman, D J. Improved Tools for Biological Sequence
Comparison. PNAS (1988) 85: 2444-8.).
[0218] The following off-target properties for every 19 mer were
extracted for each oligo-mouse transcript alignment to calculate
the off-target score: [0219] 1. Number of mismatches in seed
region, defined as positions 2-9 of the oligomer [0220] 2. Number
of mismatches in cleavage site region, defined as positions 10 and
11
[0221] 3. Number of mismatches in non-seed region, non-cleavage
region, defined as positions 12-19 [0222] 4. Mismatches in position
1 were ignored
[0223] The off-target score for each oligo-transcript pair was
calculated for considering assumptions 1 to 3 as follows:
Off-target score=(number of seed mismatches*2.8)+(number of
cleavage site mismatches*1.2)+(number of non-seed mismatches*1)
[0224] The most relevant off-target gene for each siRNA
corresponding to the input 19 mer sequence was defined as the gene
with the lowest off-target score. The candidate oligomers were
ranked first by the lowest off-target score for the antisense
sequence, and secondarily by the lowest off-target score by its
sense counterpart. The top 11 oligo sense and antisense pairs from
the list were synthesized and their capacity for knockdown of the
mouse GSK3.alpha. transcript measured. The sequences are shown in
Table 4.
[0225] Sense and antisense oligomers complementary to the human
GSK3.alpha. gene (NM.sub.--002093) were designed by first aligning
the orthologous transcripts, and then identifying the human
counterpart region of the mouse candidate target regions. The
sequences are shown in Table 6.
[0226] siRNA Design for Mouse Glycogen Synthase Kinase 3 Beta
(GSK3.beta.)
[0227] All possible perfect match sense 19 mer oligomers were
extracted from NM.sub.--019827.4 the sole NCBI reference sequence
for the mouse Gsk3.beta. gene, and identified as candidate target
regions. The sequences are shown in Table 2.
[0228] In order to rank candidate target sequences and their
corresponding siRNAs and select appropriate ones, their predicted
potential for interacting with irrelevant targets (off-target
potential) was taken as the primary ranking parameter. siRNAs with
low off-target potential were defined as preferable and assumed to
be more specific in vivo.
[0229] To identify potential off-target genes, 19 mer candidate
sequences as well as their 19 mer reverse complements were
subjected to a homology search against the entire NCBI mouse
reference mRNA sequence collection using the FASTA search algorithm
(Pearson, W R, Lipman, D J. Improved Tools for Biological Sequence
Comparison. PNAS (1988) 85: 2444-8).
[0230] The following off-target properties for every 19 mer were
extracted for each oligo-mouse transcript alignment to calculate
the off-target score: [0231] 1. Number of mismatches in seed
region, defined as positions 2-9 of the oligomer [0232] 2. Number
of mismatches in cleavage site region, defined as positions 10 and
11 [0233] 3. Number of mismatches in non-seed region, non-cleavage
region, defined as positions 12-19 [0234] 4. Mismatches in position
1 were ignored
[0235] The off-target score for each oligo-transcript pair was
calculated for considering assumptions 1 to 3 as follows:
Off-target score=(number of seed mismatches*2.8)+(number of
cleavage site mismatches*1.2)+(number of non-seed mismatches*1)
[0236] The most relevant off-target gene for each siRNA
corresponding to the input 19 mer sequence was defined as the gene
with the lowest off-target score. The candidate oligomers were
ranked first by the lowest off-target score for the antisense
sequence, and secondarily by the lowest off-target score by its
sense counterpart. The top 11 oligo sense and antisense pairs from
the list were synthesized and their capacity for knockdown of the
mouse Gsk3 .beta. transcript measured. The sequences are shown in
Table 5.
[0237] Sense and antisense oligomers complementary to the human
GSK3.beta. gene (NM.sub.--019884.2) were designed by first aligning
the orthologous transcripts, and then identifying the human
counterpart region of the mouse candidate target regions. The
sequences are shown in Table 7.
[0238] Table 3 provides a description of the abbreviations used
herein.
TABLE-US-00002 TABLE 3 Abbreviations of nucleotide monomers used in
nucleic acid sequence representation. Abbreviation.sup.a
Nucleotide(s) A adenosine-5'-phosphate C cytidine-5'-phosphate G
guanosine-5'-phosphate T, dT 2'-deoxy-thymidine-5'-phosphate U
uridine-5'-phosphate N any nucleotide (G, A, C, or T) a
2'-O-methyladenosine-5'-phosphate c
2'-O-methylcytidine-5'-phosphate g
2'-O-methylguanosine-5'-phosphate u 2'-O-methyluridine-5'-phosphate
sT, sdT 2'-deoxy-thymidine-5'phosphate-phosphorothioate It will be
understood that these monomers, when present in an oligonucleotide,
are mutually linked by 5'-3'-phosphodiester bonds.
[0239] Source of Reagents
[0240] Where the source of a reagent is not specifically given
herein, such reagent may be obtained from any supplier of reagents
for molecular biology at a quality/purity standard for application
in molecular biology.
[0241] siRNA Synthesis
[0242] Single-stranded RNAs can be produced by solid phase
synthesis on a scale of 1 .mu.mole using an Expedite 8909
synthesizer (Applied Biosystems, Applera Deutschland GmbH,
Darmstadt, Germany) and controlled pore glass (CPG, 500 .ANG.,
Proligo Biochemie GmbH, Hamburg, Germany) as solid support. RNA and
RNA containing 2'-O-methyl nucleotides can be generated by solid
phase synthesis employing the corresponding phosphoramidites and
2'-O-methyl phosphoramidites, respectively (Proligo Biochemie GmbH,
Hamburg, Germany). These building blocks can be incorporated at
selected sites within the sequence of the oligoribonucleotide chain
using standard nucleoside phosphoramidite chemistry such as
described in Current protocols in nucleic acid chemistry, Beaucage,
S. L. et al. (Edrs.), John Wiley & Sons, Inc., New York, N.Y.,
USA. Phosphorothioate linkages can be introduced by replacement of
the iodine oxidizer solution with a solution of the Beaucage
reagent (Chruachem Ltd, Glasgow, UK) in acetonitrile (1%). Further
ancillary reagents can be obtained from Mallinckrodt Baker
(Griesheim, Germany).
[0243] Deprotection and purification of the crude
oligoribonucleotides by anion exchange HPLC can be carried out
according to established procedures. Yields and concentrations can
be determined by UV absorption of a solution of the respective RNA
at a wavelength of 260 nm using a spectral photometer (DU 640B,
Beckman Coulter GmbH, Unterschlei.beta.heim, Germany). Double
stranded RNA can be generated by mixing an equimolar solution of
complementary strands in annealing buffer (20 mM sodium phosphate,
pH 6.8; 100 mM sodium chloride), heated in a water bath at
85-90.degree. C. for 3 minutes and cooled to room temperature over
a period of 3-4 hours. The annealed RNA solution can be stored at
-20.degree. C. until use.
[0244] For the synthesis of 3'-cholesterol-conjugated siRNAs
(herein referred to as -Chol-3'), an appropriately modified solid
support can be used for RNA synthesis. The modified solid support
was prepared as follows:
Diethyl-2-azabutane-1,4-dicarboxylate AA
##STR00008##
[0246] A 4.7 M aqueous solution of sodium hydroxide (50 mL) can be
added into a stirred, ice-cooled solution of ethyl glycinate
hydrochloride (32.19 g, 0.23 mole) in water (50 mL). Then, ethyl
acrylate (23.1 g, 0.23 mole) can be added and the mixture can be
stirred at room temperature until completion of the reaction can be
ascertained by TLC. After 19 h the solution can be partitioned with
dichloromethane (3.times.100 mL). The organic layer can be dried
with anhydrous sodium sulfate, filtered and evaporated. The residue
can be distilled to afford AA (28.8 g, 61%).
3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonyl-amino)-hexanoyl-
]-amino}-propionic acid ethyl ester AB
##STR00009##
[0248] Fmoc-6-amino-hexanoic acid (9.12 g, 25.83 mmol) can be
dissolved in dichloromethane (50 mL) and cooled with ice.
Diisopropylcarbodiimde (3.25 g, 3.99 mL, 25.83 mmol) can be added
to the solution at 0.degree. C. It can then be followed by the
addition of Diethyl-azabutane-1,4-dicarboxylate (5 g, 24.6 mmol)
and dimethylamino pyridine (0.305 g, 2.5 mmol). The solution can be
brought to room temperature and stirred further for 6 h. Completion
of the reaction was ascertained by TLC. The reaction mixture can be
concentrated under vacuum and ethyl acetate can be added to
precipitate diisopropyl urea. The suspension can be filtered. The
filtrate can be washed with 5% aqueous hydrochloric acid, 5% sodium
bicarbonate and water. The combined organic layer can be dried over
sodium sulfate and concentrated to give the crude product which can
be purified by column chromatography (50% EtOAC/Hexanes) to yield
11.87 g (88%) of AB.
3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid
ethyl ester AC
##STR00010##
[0250]
3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-he-
xanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol)
can be dissolved in 20% piperidine in dimethylformamide at
0.degree. C. The solution can be stirred continuously for 1 h. The
reaction mixture can be concentrated under vacuum, water can be
added to the residue, and the product can be extracted with ethyl
acetate. The crude product can be purified by conversion into its
hydrochloride salt.
3-({6-[17-(1,5-D
imethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetrade-
cahydro-1H-cyclopenta[a]phenanthren-3-yloxycarbonylamino]-hexanoyl}ethoxyc-
arbonylmethyl-amino)-propionic acid ethyl ester AD
##STR00011##
[0252] The hydrochloride salt of
3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid
ethyl ester AC (4.7 g, 14.8 mmol) can be taken up in
dichloromethane. The suspension was cooled to 0.degree. C. on ice.
To the suspension diisopropylethylamine (3.87 g, 5.2 mL, 30 mmol)
can be added. To the resulting solution cholesteryl chloroformate
(6.675 g, 14.8 mmol) can be added. The reaction mixture can be
stirred overnight. The reaction mixture can be diluted with
dichloromethane and washed with 10% hydrochloric acid. The product
can be purified by flash chromatography (10.3 g, 92%).
1-{6-[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-
,16,17-tetradecahydro-1H-cyclopenta[a]
phenanthren-3-yloxycarbonylamino]-hexanoyl}-4-oxo-pyrrolidine-3-carboxyli-
c acid ethyl ester AE
##STR00012##
[0254] Potassium t-butoxide (1.1 g, 9.8 mmol) can be slurried in 30
mL of dry toluene. The mixture can be cooled to 0.degree. C. on ice
and 5 g (6.6 mmol) of diester AD can be added slowly with stirring
within 20 mins. The temperature can be kept below 5.degree. C.
during the addition. The stirring can be continued for 30 mins at
0.degree. C. and 1 mL of glacial acetic acid can be added,
immediately followed by 4 g of NaH.sub.2PO.sub.4.H.sub.2O in 40 mL
of water. The resultant mixture can be extracted twice with 100 mL
of dichloromethane each and the combined organic extracts can be
washed twice with 10 mL of phosphate buffer each, dried, and
evaporated to dryness. The residue can be dissolved in 60 mL of
toluene, cooled to 0.degree. C. and extracted with three 50 mL
portions of cold pH 9.5 carbonate buffer. The aqueous extracts can
be adjusted to pH 3 with phosphoric acid, and extracted with five
40 mL portions of chloroform which can be combined, dried and
evaporated to dryness. The residue can be purified by column
chromatography using 25% ethylacetate/hexane to afford 1.9 g of
b-ketoester (39%).
[6-(3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-yl)-6-oxo-hexyl]-carbamic
acid
17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,1-
7-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester AF
##STR00013##
[0256] Methanol (2 mL) can be added dropwise over a period of 1 h
to a refluxing mixture of b-ketoester AE (1.5 g, 2.2 mmol) and
sodium borohydride (0.226 g, 6 mmol) in tetrahydrofuran (10 mL).
Stirring can be continued at reflux temperature for 1 h. After
cooling to room temperature, 1 N HCl (12.5 mL) can be added, the
mixture was extracted with ethylacetate (3.times.40 mL). The
combined ethylacetate layer can be dried over anhydrous sodium
sulfate and concentrated under vacuum to yield the product which
can be purified by column chromatography (10% MeOH/CHCl.sub.3)
(89%).
(6-{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-pyrrolidin-1-
-yl}-6-oxo-hexyl)-carbamic acid
17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,1-
7-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester AG
##STR00014##
[0258] Diol AF (1.25 gm 1.994 mmol) can be dried by evaporating
with pyridine (2.times.5 mL) in vacuo. Anhydrous pyridine (10 mL)
and 4,4'-dimethoxytritylchloride (0.724 g, 2.13 mmol) can be added
with stirring. The reaction can be carried out at room temperature
overnight. The reaction can be quenched by the addition of
methanol. The reaction mixture can be concentrated under vacuum and
to the residue dichloromethane (50 mL) was added. The organic layer
can be washed with 1M aqueous sodium bicarbonate. The organic layer
can be dried over anhydrous sodium sulfate, filtered and
concentrated. The residual pyridine can be removed by evaporating
with toluene. The crude product can be purified by column
chromatography (2% MeOH/Chloroform, Rf=0.5 in 5% MeOH/CHCl.sub.3)
(1.75 g, 95%).
Succinic acid
mono-(4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-{6-[17-(1,5-dimet-
hyl-hexyl)-10,13-dimethyl
2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H
cyclopenta[a]phenanthren-3-yloxycarbonylamino]-hexanoyl}-pyrrolidin-3-yl)
ester AH
##STR00015##
[0260] Compound AG (1.0 g, 1.05 mmol) can be mixed with succinic
anhydride (0.150 g, 1.5 mmol) and DMAP (0.073 g, 0.6 mmol) and
dried in a vacuum at 40.degree. C. overnight. The mixture can be
dissolved in anhydrous dichloroethane (3 mL), triethylamine (0.318
g, 0.440 mL, 3.15 mmol) can be added and the solution can be
stirred at room temperature under argon atmosphere for 16 h. It can
then be diluted with dichloromethane (40 mL) and washed with ice
cold aqueous citric acid (5 wt %, 30 mL) and water (2.times.20 mL).
The organic phase can be dried over anhydrous sodium sulfate and
concentrated to dryness. The residue can be used as such for the
next step.
Cholesterol Derivatised CPG AI
##STR00016##
[0262] Succinate AH (0.254 g, 0.242 mmol) can be dissolved in a
mixture of dichloromethane/acetonitrile (3:2, 3 mL). To that
solution DMAP (0.0296 g, 0.242 mmol) in acetonitrile (1.25 mL),
2,2'-Dithio-bis(5-nitropyridine) (0.075 g, 0.242 mmol) in
acetonitrile/dichloroethane (3:1, 1.25 mL) can be added
successively. To the resulting solution triphenylphosphine (0.064
g, 0.242 mmol) in acetonitrile (0.6 ml) was added. The reaction
mixture can turn bright orange in color. The solution can be
agitated briefly using a wrist-action shaker (5 mins). Long chain
alkyl amine-CPG (LCAA-CPG) (1.5 g, 61 mM) can be added. The
suspension can be agitated for 2 h. The CPG was filtered through a
sintered funnel and washed with acetonitrile, dichloromethane and
ether successively. Unreacted amino groups can be masked using
acetic anhydride/pyridine. The achieved loading of the CPG can be
measured by taking UV measurement (37 mM/g).
[0263] The synthesis of siRNAs bearing a 5'-12-dodecanoic acid
bisdecylamide group (herein referred to as "5'-C32-") or a
5'-cholesteryl derivative group (herein referred to as "5'-Chol-")
can be performed as described in WO 2004/065601, except that, for
the cholesteryl derivative, the oxidation step can be performed
using the Beaucage reagent in order to introduce a phosphorothioate
linkage at the 5'-end of the nucleic acid oligomer.
Example 2
In Vitro Screen of GSK3.alpha. and GSK3.beta. siRNAs Against
Endogenous GSK3.alpha. and GSK3.beta. mRNA Expression in Mouse HT22
Cells
[0264] Mouse HT22 cells were a gift from Dr. Marcy MacDonald and
cultured in Dulbecco's modified Eagle's medium supplied with 10%
fetal bovine serum and differentiated in modified serum-free medium
(Dulbecco's modified Eagle's medium, N2 supplement, 50 ng/ml nerve
growth factor-.beta., 100 .mu.M phorbol 12,13-dibutyrate, 100 .mu.M
dibutyryl cAMP) for 24-48 h before treatment. All treatments were
performed in differentiation medium with reduced nerve growth
factor-.beta. content (5 ng/ml) at 37.degree. C. in a humidified
incubator with 5% CO.sub.2.
[0265] Cells were transfected with the modified siRNA targeting
mouse GSK3.alpha. or GSK3.beta. described in Table 4 and Table 5.
For transfection with siRNA, HT22 cells were seeded at a density of
1.0.times.10.sup.5 cells/well in 6-well tissue culture plates and
transfected directly. Transfection of siRNA (37.5 nM for single
dose screen) was carried out with Lipofectamine-2000 (Invitrogen,
Carlsbad, Calif.) as described by the manufacturer. For
dose-response curves, siRNA concentrations ranged from 10 nM to 0.1
nM in 10-fold dilutions.
[0266] 24 hours after transfection, HT22 cells were lysed and cDNA
was generated for GSK3.alpha. or GSK3.beta. and GAPDH mRNA
quantitation. GSK3.alpha. or GSK3.beta. mRNA levels were normalized
to GAPDH mRNA levels. For each siRNA, 2 individual data points were
collected. An siRNA duplex unrelated to the GSK3.alpha. or
GSK3.beta. gene was used as a control. The activity of a given
GSK3.alpha.- or GSK313-specific siRNA duplex was expressed as the
fraction of the GSK3.alpha. or GSK3.beta. mRNA level in treated
cells relative to the GSK3.alpha. or GSK3.beta. mRNA level in cells
treated with the control siRNA duplex.
[0267] Duplex identifier used in the Figures and in Examples 2-5
refer to the modified version of the duplex, e.g., AD-18821 as used
in the Figures and Examples 2-5 refers to the modified version of
AD-18821, e.g., AD-18821-b1.
[0268] FIG. 1 and FIG. 2 provide the results from the in vitro HT22
screen where the siRNAs were tested at a single dose of 37.5 nM.
The fraction of GSK3.alpha. and GSK3.beta. mRNA remaining in
treated cells compared to controls, .+-.standard deviation, is
shown. A number of GSK3.alpha. siRNAs (AD-18821, AD-18825 or
AD-18832) at 37.5 nM were effective at reducing GSK3.alpha. mRNA
levels by more than 40%, without affecting GSK3.beta. mRNA levels,
in HT22 cells. A number of GSK3.beta. siRNAs (AD-18833, AD-18834,
AD-18836, AD-18837, AD-18838, AD-18841, AD-18842, AD-18843 or
AD-18844) at 37.5 nM were effective at reducing GSK3 .beta. mRNA
levels by more than 40%, without affecting GSK3.alpha. mRNA levels,
in HT22 cells.
[0269] FIG. 3 and FIG. 4 show the dose-dependence of selected
siRNAs on mRNA reduction in HT22 cells. Several siRNAs targeting
GSK3.alpha. (AD-18821, AD-18825 or AD-18826) exhibited IC50 values
of less than or equal to 1-10 nM in suppressing GSK3.alpha. mRNA
after transfection into HT22 cells (FIG. 3). Several siRNAs
targeting GSK3.beta. (AD-18838 or AD-18843) exhibited IC50 values
of less than 1 nM in suppressing GSK3.beta. mRNA (FIG. 4).
Example 3
GSK3.beta. dsRNAs reduce endogenous GSK3.beta. protein in HT22
cells
[0270] HT22 cells were cultured and transfected as previously
described with 75 nM of 11 siRNAs against GSK3.beta. (AD-18833,
AD-18834, AD-18835, AD-18836, AD-18837, AD-18838, AD-18839,
AD-18841, AD-18842, AD-18843 or AD-18844); one control unrelated
siRNA (AD-1955) or Lipofectamine-2000 alone (Control). 48 hours
post-transfection, the cells were harvested and lysed. Proteins in
the lysates were separated on a denaturing polyacrylamide gel.
GSK3.beta. and .beta.-actin were detected by standard western blot
protocols using antibodies that bind to the proteins. For
GSK3.beta. detection, the membrane was probed with a monoclonal
GSK3.beta. antibody produced in rabbit (Cell Signaling, Danvers,
Mass.) followed by a secondary antibody donkey anti-rabbit IgG
horseradish peroxidase (GE Healthcare, Piscataway, N.J.).
.beta.-actin was detected by mouse anti-actin antibody (Sigma, St.
Louis, Mo.) followed by a Sheep anti-mouse IgG horseradish
peroxidase secondary antibody (GE Healthcare, Piscataway,
N.J.).
[0271] FIG. 5 provides the results. AD-18838, AD-18843 and
AD-18844, all at 75 nM, decreased the level of GSK3.beta. protein
relative to the control protein .beta.-actin, whereas the control
unrelated siRNA had no effect on the level of GSK3.beta. protein.
These results demonstrate that dsRNAs targeting GSK3.beta.
effectively reduce not only GSK3.beta. mRNA levels, but also
GSK3.beta. protein levels.
Example 4
In Vivo Down-Modulation of Endogenous GSK3.alpha. or GSK3.beta.
mRNA Levels by CNS Administration of GSK3.alpha. or GSK3.beta.
dsRNAs in Mice
[0272] To assess the biological activity of GSK3 dsRNAs in vivo,
dsRNAs targeting GSK3.alpha.(AD-18821, AD-18825, and AD-18826) or
GSK3.beta. (AD-18838, AD-18843, and AD-18844) were evaluated.
[0273] In mice, 1.26 mg AD-18821, AD-18825, AD-18826, AD-18838,
AD-18843, AD-18844, or phosphate-buffered saline (PBS, vehicle
control) was administered by continuous infusion into the nucleus
accumbens over 14 days. Ten week old male C57BL6 mice (Charles
River Laboratory) received stereotaxic implantations of 30-gauge
infusion cannulae (Plastics One, Roanok, Va.) such that unilateral
infusions were targeted to the nucleus accumbens (anteroposterior
+1.1 mm, mediolateral +1.3 mm, relative to bregma; dorsoventral 4.5
mm, relative to skull surface). Mini-osmotic pumps (model 1002)
were primed overnight according to the manufacturer's
specifications, implanted subcutaneously, and connected via
catheters, to deliver (6 mice per treatment group) PBS, 1.1 mM (15
mg/mL) of GSK3.alpha. siRNAs (AD-18821, AD-18825, or AD-18826) or
1.1 mM (15 mg/mL) of GSK3.beta. siRNAs (AD-18838, AD-18843, or
AD-18844) at 0.25 .mu.L/hr over 14 days. At the end of the 14 day
infusion period, animals were sacrificed, brains were removed, and
1.2 mm punches from the ipsilateral nucleus accumbens encompassing
the infusion site, from 1 mm thick coronal brain slabs, were flash
frozen and stored at -80.degree. C. Individual brain punches from
each mouse were quantified for GSK3.alpha. and GSK3.beta. mRNA.
Each brain punch was run in triplicate for RT-qPCR. Approximately
60 ng of total RNA in a 20 .mu.l total reaction volume was used for
RT-qPCR. GSK3.alpha. and GSK3.beta. primers were custom designed
and obtained from IDT (Integrated DNA Technologies, Inc.,
Coralville, Iowa). RT-qPCR was run with SBYR. GAPDH was used as the
internal control for normalization. Relative expression of
GSK3.alpha. and GSK3.beta. mRNA was quantified by 2.sup..DELTA.Ct
(where .DELTA.Ct=Ct.sub.gene-Ct.sub.GAPDH).
[0274] The GSK3.beta. siRNAs, AD-18844, AD-18838 or AD-18843,
showed 53% (ANOVA; p=0.012) (FIG. 6), 28% or 25% GSK3.beta. mRNA
reduction in the ipsilateral nucleus accumbens, respectively,
compared to PBS control. The GSK3.beta. siRNA, AD-18844, had no
effect on GSK3.alpha.mRNA levels. The GSK3.alpha. siRNAs, AD-18826,
AD-18825 or AD-18821, showed 51% (p=0.052; Tukey Post-hoc ANOVA)
(FIG. 7), 42% (t-test; p=0.004) or 15% GSK3.alpha. mRNA reduction
in the ipsilateral nucleus accumbens, respectively, compared to PBS
control. The GSK3.alpha. siRNA, AD-18826, had no effect on
GSK3.beta. mRNA levels.
[0275] These results demonstrate that infusion into the nucleus
accumbens of AD-18844 and AD-18826 are efficacious in vivo in
specifically down-modulating GSK3.beta. and GSK3.alpha. mRNA
levels, respectively, in the nucleus accumbens.
Example 5
Inhibition of GSK-3 Expression in Human Cells
[0276] A set of siRNA targeting human GSK3.alpha. and GSK3.beta.
(Table 6 and Table 7) are evaluated for inhibition of GSK-3
expression in human cell lines. Human cell lines expressing
endogenouseGSK3 are transfected with at least one of the duplexes
in Table 6 or Table 7, e.g., huGSKA-3 (orthologous to AD-18826-b1)
and/or huGSKB-11 (orthologous to AD-18826-b1).
[0277] The human duplexes can be modified in a similar manner to
the mouse duplexes. The transfected cells are assayed for effects
on mRNA and protein levels using techniques described herein and
known to one of skill in the art.
Example 6
Inhibition of GSK-3 Expression in Humans
[0278] A human subject is treated with a pharmaceutical composition
comprising a pharmaceutical formulation of an siRNA targeting a
human GSK-3 gene.
[0279] A subject in need of treatment is selected or identified.
The subject can be in need of treatment for manic depression, a
metabolic disease, a nervous system disorders, or cancer.
[0280] At time zero, a suitable first dose of the composition is
subcutaneously administered to the subject. The composition is
formulated as described herein. After a period of time, the
subject's condition is evaluated, e.g., by measurement episodes of
mania, episodes of depression, and the like. This measurement can
be accompanied by a measurement of GSK-3 expression in said
subject, and/or the products of the successful siRNA-targeting of
GSK-3. Other relevant criteria can also be measured. The number and
strength of doses are adjusted according to the subject's
needs.
[0281] After treatment, the subject's condition is compared to the
condition existing prior to the treatment, or relative to the
condition of a similarly afflicted but untreated subject.
TABLE-US-00003 TABLE 1 Sequences of duplexes targeting Mouse
GSK3-alpha Sequences of possible duplexes targeting mouse
GSK3-alpha. Target sequence location identifies target sequence in
mouse GSK3-alpha mRNA NM_001031667.1. Unmodified sense strand is
identical to target sequence. Unmodified a antisense strand is
complementary to target sequence. Target SEQ SEQ sequence ID
Unmodified sequence ID Modified sequence location NO: 5' to 3' NO:
5' to 3' Strand 670-689 1 AACUGCAGAUUAUGCGUAA 2
AAcuGcAGAuuAuGcGuAAdTsdT sense 670-689 3 UUACGCAUAAUCUGCAGUU 4
UuACGcAuAAUCUGcAGUUdTsdT antis 1074-1093 5 ACAGAUUACACCUCGUCCA 6
AcAGAuuAcAccucGuccAdTsdT sense 1074-1093 7 UGGACGAGGUGUAAUCUGU 8
UGGACGAGGUGuAAUCUGUdTsdT antis 330-349 9 GGCGGCGGGAAAGCGUCAG 10
GGcGGcGGGAAAGcGucAGdTsdT sense 330-349 11 CUGACGCUUUCCCGCCGCC 12
CUGACGCUUUCCCGCCGCCdTsdT antis 239-258 13 GGCGCGGACCAGCUCGUUC 14
GGcGcGGAccAGcucGuucdTsdT sense 239-258 15 GAACGAGCUGGUCCGCGCC 16
GAACGAGCUGGUCCGCGCCdTsdT antis 1340-1359 17 CCUACUGGAGUACACGCCA 18
ccuAcuGGAGuAcAcGccAdTsdT sense 1340-1359 19 UGGCGUGUACUCCAGUAGG 20
UGGCGUGuACUCcAGuAGGdTsdT antis 1342-1361 21 UACUGGAGUACACGCCAUC 22
uAcuGGAGuAcAcGccAucdTsdT sense 1342-1361 23 GAUGGCGUGUACUCCAGUA 24
GAUGGCGUGuACUCcAGuAdTsdT antis 1073-1092 25 CACAGAUUACACCUCGUCC 26
cAcAGAuuAcAccucGuccdTsdT sense 1073-1092 27 GGACGAGGUGUAAUCUGUG 28
GGACGAGGUGuAAUCUGUGdTsdT antis 1236-1255 29 CCUAACUAUACGGAGUUCA 30
ccuAAcuAuAcGGAGuucAdTsdT sense 1236-1255 31 UGAACUCCGUAUAGUUAGG 32
UGAACUCCGuAuAGUuAGGdTsdT antis 435-454 33 GCGGGCACUAGCUUCCCGC 34
GcGGGcAcuAGcuucccGcdTsdT sense 435-454 35 GCGGGAAGCUAGUGCCCGC 36
GCGGGAAGCuAGUGCCCGCdTsdT antis 1231-1250 37 UGAACCCUAACUAUACGGA 38
uGAAcccuAAcuAuAcGGAdTsdT sense 1231-1250 39 UCCGUAUAGUUAGGGUUCA 40
UCCGuAuAGUuAGGGUUcAdTsdT antis 1234-1253 41 ACCCUAACUAUACGGAGUU 42
AcccuAAcuAuAcGGAGuudTsdT sense 1234-1253 43 AACUCCGUAUAGUUAGGGU 44
AACUCCGuAuAGUuAGGGUdTsdT antis 1235-1254 45 CCCUAACUAUACGGAGUUC 46
cccuAAcuAuAcGGAGuucdTsdT sense 1235-1254 47 GAACUCCGUAUAGUUAGGG 48
GAACUCCGuAuAGUuAGGGdTsdT antis 1233-1252 49 AACCCUAACUAUACGGAGU 50
AAcccuAAcuAuAcGGAGudTsdT sense 1233-1252 51 ACUCCGUAUAGUUAGGGUU 52
ACUCCGuAuAGUuAGGGUUdTsdT antis 2027-2046 53 GCCCCCUGGGUGUAAAUAG 54
GcccccuGGGuGuAAAuAGdTsdT sense 2027-2046 55 CUAUUUACACCCAGGGGGC 56
CuAUUuAcACCcAGGGGGCdTsdT antis 5-24 57 UGACAACGAAGCCGACGGC 58
uGAcAAcGAAGccGAcGGcdTsdT sense 5-24 59 GCCGUCGGCUUCGUUGUCA 60
GCCGUCGGCUUCGUUGUcAdTsdT antis 1071-1090 61 GCCACAGAUUACACCUCGU 62
GccAcAGAuuAcAccucGudTsdT sense 1071-1090 63 ACGAGGUGUAAUCUGUGGC 64
ACGAGGUGuAAUCUGUGGCdTsdT antis 2000-2019 65 AGCCCAUCUCUCGUCUUCC 66
AGcccAucucucGucuuccdTsdT sense 2000-2019 67 GGAAGACGAGAGAUGGGCU 68
GGAAGACGAGAGAUGGGCUdTsdT antis 4-23 69 GUGACAACGAAGCCGACGG 70
GuGAcAAcGAAGccGAcGGdTsdT sense 4-23 71 CCGUCGGCUUCGUUGUCAC 72
CCGUCGGCUUCGUUGUcACdTsdT antis 1085-1104 73 CUCGUCCAUCGAUGUGUGG 74
cucGuccAucGAuGuGuGGdTsdT sense 1085-1104 75 CCACACAUCGAUGGACGAG 76
CcAcAcAUCGAUGGACGAGdTsdT antis 2070-2089 77 AAACGUCAAUUCACACCAU 78
AAAcGucAAuucAcAccAudTsdT sense 2070-2089 79 AUGGUGUGAAUUGACGUUU 80
AUGGUGUGAAUUGACGUUUdTsdT antis 2072-2091 81 ACGUCAAUUCACACCAUUC 82
AcGucAAuucAcAccAuucdTsdT sense 2072-2091 83 GAAUGGUGUGAAUUGACGU 84
GAAUGGUGUGAAUUGACGUdTsdT antis 251-270 85 CUCGUUCGCGGAGCCAGGA 86
cucGuucGcGGAGccAGGAdTsdT sense 251-270 87 UCCUGGCUCCGCGAACGAG 88
UCCUGGCUCCGCGAACGAGdTsdT antis 241-260 89 CGCGGACCAGCUCGUUCGC 90
cGcGGAccAGcucGuucGcdTsdT sense 241-260 91 GCGAACGAGCUGGUCCGCG 92
GCGAACGAGCUGGUCCGCGdTsdT antis 581-600 93 CGGAGUAGUAUACCAGGCA 94
cGGAGuAGuAuAccAGGcAdTsdT sense 581-600 95 UGCCUGGUAUACUACUCCG 96
UGCCUGGuAuACuACUCCGdTsdT antis 1076-1095 97 AGAUUACACCUCGUCCAUC 98
AGAuuAcAccucGuccAucdTsdT sense 1076-1095 99 GAUGGACGAGGUGUAAUCU 100
GAUGGACGAGGUGuAAUCUdTsdT antis 2069-2088 101 AAAACGUCAAUUCACACCA
102 AAAAcGucAAuucAcAccAdTsdT sense 2069-2088 103
UGGUGUGAAUUGACGUUUU 104 UGGUGUGAAUUGACGUUUUdTsdT antis 6-25 105
GACAACGAAGCCGACGGCA 106 GAcAAcGAAGccGAcGGcAdTsdT sense 6-25 107
UGCCGUCGGCUUCGUUGUC 108 UGCCGUCGGCUUCGUUGUCdTsdT antis 16-35 109
CCGACGGCAGAGGGACUUC 110 ccGAcGGcAGAGGGAcuucdTsdT sense 16-35 111
GAAGUCCCUCUGCCGUCGG 112 GAAGUCCCUCUGCCGUCGGdTsdT antis 243-262 113
CGGACCAGCUCGUUCGCGG 114 cGGAccAGcucGuucGcGGdTsdT sense 243-262 115
CCGCGAACGAGCUGGUCCG 116 CCGCGAACGAGCUGGUCCGdTsdT antis 244-263 117
GGACCAGCUCGUUCGCGGA 118 GGAccAGcucGuucGcGGAdTsdT sense 244-263 119
UCCGCGAACGAGCUGGUCC 120 UCCGCGAACGAGCUGGUCCdTsdT antis 328-347 121
CUGGCGGCGGGAAAGCGUC 122 cuGGcGGcGGGAAAGcGucdTsdT sense 328-347 123
GACGCUUUCCCGCCGCCAG 124 GACGCUUUCCCGCCGCcAGdTsdT antis 331-350 125
GCGGCGGGAAAGCGUCAGU 126 GcGGcGGGAAAGcGucAGudTsdT sense 331-350 127
ACUGACGCUUUCCCGCCGC 128 ACUGACGCUUUCCCGCCGCdTsdT antis 340-359 129
AAGCGUCAGUCGGGGCUAU 130 AAGcGucAGucGGGGcuAudTsdT sense 340-359 131
AUAGCCCCGACUGACGCUU 132 AuAGCCCCGACUGACGCUUdTsdT antis 432-451 133
GGCGCGGGCACUAGCUUCC 134 GGcGcGGGcAcuAGcuuccdTsdT sense 432-451 135
GGAAGCUAGUGCCCGCGCC 136 GGAAGCuAGUGCCCGCGCCdTsdT antis 655-674 137
GGUUCAAGAACCGAGAACU 138 GGuucAAGAAccGAGAAcudTsdT sense 655-674 139
AGUUCUCGGUUCUUGAACC 140 AGUUCUCGGUUCUUGAACCdTsdT antis 1024-1043
141 CCUACAUCUGCUCUCGGUA 142 ccuAcAucuGcucucGGuAdTsdT sense
1024-1043 143 UACCGAGAGCAGAUGUAGG 144 uACCGAGAGcAGAUGuAGGdTsdT
antis 1075-1094 145 CAGAUUACACCUCGUCCAU 146
cAGAuuAcAccucGuccAudTsdT sense 1075-1094 147 AUGGACGAGGUGUAAUCUG
148 AUGGACGAGGUGuAAUCUGdTsdT antis 1089-1108 149
UCCAUCGAUGUGUGGUCGG 150 uccAucGAuGuGuGGucGGdTsdT sense 1089-1108
151 CCGACCACACAUCGAUGGA 152 CCGACcAcAcAUCGAUGGAdTsdT antis
1090-1109 153 CCAUCGAUGUGUGGUCGGC 154 ccAucGAuGuGuGGucGGcdTsdT
sense 1090-1109 155 GCCGACCACACAUCGAUGG 156
GCCGACcAcAcAUCGAUGGdTsdT antis 1092-1111 157 AUCGAUGUGUGGUCGGCUG
158 AucGAuGuGuGGucGGcuGdTsdT sense 1092-1111 159
CAGCCGACCACACAUCGAU 160 cAGCCGACcAcAcAUCGAUdTsdT antis 1093-1112
161 UCGAUGUGUGGUCGGCUGG 162 ucGAuGuGuGGucGGcuGGdTsdT sense
1093-1112 163 CCAGCCGACCACACAUCGA 164 CcAGCCGACcAcAcAUCGAdTsdT
antis 1230-1249 165 AUGAACCCUAACUAUACGG 166
AuGAAcccuAAcuAuAcGGdTsdT sense 1230-1249 167 CCGUAUAGUUAGGGUUCAU
168 CCGuAuAGUuAGGGUUcAUdTsdT antis 1348-1367 169
AGUACACGCCAUCCUCAAG 170 AGuAcAcGccAuccucAAGdTsdT sense 1348-1367
171 CUUGAGGAUGGCGUGUACU 172 CUUGAGGAUGGCGUGuACUdTsdT antis
1401-1420 173 UUCGAUGAACUGCGGAGAC 174 uucGAuGAAcuGcGGAGAcdTsdT
sense 1401-1420 175 GUCUCCGCAGUUCAUCGAA 176
GUCUCCGcAGUUcAUCGAAdTsdT antis 1402-1421 177 UCGAUGAACUGCGGAGACU
178 ucGAuGAAcuGcGGAGAcudTsdT sense 1402-1421 179
AGUCUCCGCAGUUCAUCGA 180 AGUCUCCGcAGUUcAUCGAdTsdT antis 1489-1508
181 UCCAACCAUCUCUCAAUGC 182 uccAAccAucucucAAuGcdTsdT sense
1489-1508 183 GCAUUGAGAGAUGGUUGGA 184 GcAUUGAGAGAUGGUUGGAdTsdT
antis 1999-2018 185 CAGCCCAUCUCUCGUCUUC 186
cAGcccAucucucGucuucdTsdT sense 1999-2018 187 GAAGACGAGAGAUGGGCUG
188 GAAGACGAGAGAUGGGCUGdTsdT antis 2028-2047 189
CCCCCUGGGUGUAAAUAGA 190 cccccuGGGuGuAAAuAGAdTsdT sense 2028-2047
191 UCUAUUUACACCCAGGGGG 192 UCuAUUuAcACCcAGGGGGdTsdT antis
2068-2087 193 GAAAACGUCAAUUCACACC 194 GAAAAcGucAAuucAcAccdTsdT
sense 2068-2087 195 GGUGUGAAUUGACGUUUUC 196
GGUGUGAAUUGACGUUUUCdTsdT antis 2080-2099 197 UCACACCAUUCAACUUGCC
198 ucAcAccAuucAAcuuGccdTsdT sense 2080-2099 199
GGCAAGUUGAAUGGUGUGA 200 GGcAAGUUGAAUGGUGUGAdTsdT antis 2083-2102
201 CACCAUUCAACUUGCCCCC 202 cAccAuucAAcuuGcccccdTsdT sense
2083-2102 203 GGGGGCAAGUUGAAUGGUG 204 GGGGGcAAGUUGAAUGGUGdTsdT
antis 2084-2103 205 ACCAUUCAACUUGCCCCCC 206
AccAuucAAcuuGccccccdTsdT sense 2084-2103 207 GGGGGGCAAGUUGAAUGGU
208 GGGGGGcAAGUUGAAUGGUdTsdT antis 2086-2105 209
CAUUCAACUUGCCCCCCCC 210 cAuucAAcuuGccccccccdTsdT sense 2086-2105
211 GGGGGGGGCAAGUUGAAUG 212 GGGGGGGGcAAGUUGAAUGdTsdT antis
2244-2263 213 UUGGCAUGAAACCCUUAAA 214 uuGGcAuGAAAcccuuAAAdTsdT
sense 2244-2263 215 UUUAAGGGUUUCAUGCCAA 216
UUuAAGGGUUUcAUGCcAAdTsdT antis 71-90 217 AGCCGGAGCCCGAACGGCG 218
AGccGGAGcccGAAcGGcGdTsdT sense 71-90 219 CGCCGUUCGGGCUCCGGCU 220
CGCCGUUCGGGCUCCGGCUdTsdT antis 177-196 221 CCUGCGCUCGGCGCCAUGA 222
ccuGcGcucGGcGccAuGAdTsdT sense 177-196 223 UCAUGGCGCCGAGCGCAGG 224
UcAUGGCGCCGAGCGcAGGdTsdT antis 836-855 225 CACCCCUAUCAUCUACAUC 226
cAccccuAucAucuAcAucdTsdT sense 836-855 227 GAUGUAGAUGAUAGGGGUG 228
GAUGuAGAUGAuAGGGGUGdTsdT antis 929-948 229 GCCCCAGAAUUUGCUUGUG 230
GccccAGAAuuuGcuuGuGdTsdT sense 929-948 231 CACAAGCAAAUUCUGGGGC 232
cAcAAGcAAAUUCUGGGGCdTsdT antis 1001-1020 233 GGUUCGGGGGGAGCCCAAU
234 GGuucGGGGGGAGcccAAudTsdT sense 1001-1020 235
AUUGGGCUCCCCCCGAACC 236 AUUGGGCUCCCCCCGAACCdTsdT antis 1091-1110
237 CAUCGAUGUGUGGUCGGCU 238 cAucGAuGuGuGGucGGcudTsdT sense
1091-1110 239 AGCCGACCACACAUCGAUG 240 AGCCGACcAcAcAUCGAUGdTsdT
antis 1328-1347 241 ACUCUGCUCUAGCCUACUG 242
AcucuGcucuAGccuAcuGdTsdT sense 1328-1347 243 CAGUAGGCUAGAGCAGAGU
244 cAGuAGGCuAGAGcAGAGUdTsdT antis 1338-1357 245
AGCCUACUGGAGUACACGC 246 AGccuAcuGGAGuAcAcGcdTsdT sense 1338-1357
247 GCGUGUACUCCAGUAGGCU 248 GCGUGuACUCcAGuAGGCUdTsdT antis
1339-1358 249 GCCUACUGGAGUACACGCC 250 GccuAcuGGAGuAcAcGccdTsdT
sense 1339-1358 251 GGCGUGUACUCCAGUAGGC 252
GGCGUGuACUCcAGuAGGCdTsdT antis 2059-2078 253 UUUCUUAAAGAAAACGUCA
254 uuucuuAAAGAAAAcGucAdTsdT sense 2059-2078 255
UGACGUUUUCUUUAAGAAA 256 UGACGUUUUCUUuAAGAAAdTsdT antis 2067-2086
257 AGAAAACGUCAAUUCACAC 258 AGAAAAcGucAAuucAcAcdTsdT sense
2067-2086 259 GUGUGAAUUGACGUUUUCU 260 GUGUGAAUUGACGUUUUCUdTsdT
antis 2076-2095 261 CAAUUCACACCAUUCAACU 262
cAAuucAcAccAuucAAcudTsdT sense 2076-2095 263 AGUUGAAUGGUGUGAAUUG
264 AGUUGAAUGGUGUGAAUUGdTsdT antis 2089-2108 265
UCAACUUGCCCCCCCCAGC 266 ucAAcuuGccccccccAGcdTsdT sense 2089-2108
267 GCUGGGGGGGGCAAGUUGA 268 GCUGGGGGGGGcAAGUUGAdTsdT antis
2231-2250 269 GUUCAAUAAAUUAUUGGCA 270 GuucAAuAAAuuAuuGGcAdTsdT
sense 2231-2250 271 UGCCAAUAAUUUAUUGAAC 272
UGCcAAuAAUUuAUUGAACdTsdT antis 207-226 273 CCUUCGGGAGGCGGCCCUG 274
ccuucGGGAGGcGGcccuGdTsdT sense 207-226 275 CAGGGCCGCCUCCCGAAGG 276
cAGGGCCGCCUCCCGAAGGdTsdT antis 240-259 277 GCGCGGACCAGCUCGUUCG 278
GcGcGGAccAGcucGuucGdTsdT sense 240-259 279 CGAACGAGCUGGUCCGCGC 280
CGAACGAGCUGGUCCGCGCdTsdT antis 242-261 281 GCGGACCAGCUCGUUCGCG 282
GcGGAccAGcucGuucGcGdTsdT sense 242-261 283 CGCGAACGAGCUGGUCCGC 284
CGCGAACGAGCUGGUCCGCdTsdT antis 249-268 285 AGCUCGUUCGCGGAGCCAG 286
AGcucGuucGcGGAGccAGdTsdT sense 249-268 287 CUGGCUCCGCGAACGAGCU 288
CUGGCUCCGCGAACGAGCUdTsdT antis 252-271 289 UCGUUCGCGGAGCCAGGAG 290
ucGuucGcGGAGccAGGAGdTsdT sense 252-271 291 CUCCUGGCUCCGCGAACGA 292
CUCCUGGCUCCGCGAACGAdTsdT antis 324-343 293 GGCACUGGCGGCGGGAAAG 294
GGcAcuGGcGGcGGGAAAGdTsdT sense 324-343 295 CUUUCCCGCCGCCAGUGCC 296
CUUUCCCGCCGCcAGUGCCdTsdT antis 329-348 297 UGGCGGCGGGAAAGCGUCA 298
uGGcGGcGGGAAAGcGucAdTsdT sense 329-348 299 UGACGCUUUCCCGCCGCCA 300
UGACGCUUUCCCGCCGCcAdTsdT antis 427-446 301 GCCCCGGCGCGGGCACUAG 302
GccccGGcGcGGGcAcuAGdTsdT sense 427-446 303 CUAGUGCCCGCGCCGGGGC 304
CuAGUGCCCGCGCCGGGGCdTsdT antis 428-447 305 CCCCGGCGCGGGCACUAGC 306
ccccGGcGcGGGcAcuAGcdTsdT sense 428-447 307 GCUAGUGCCCGCGCCGGGG 308
GCuAGUGCCCGCGCCGGGGdTsdT antis 429-448 309 CCCGGCGCGGGCACUAGCU 310
cccGGcGcGGGcAcuAGcudTsdT sense 429-448 311 AGCUAGUGCCCGCGCCGGG 312
AGCuAGUGCCCGCGCCGGGdTsdT antis 430-449 313 CCGGCGCGGGCACUAGCUU 314
ccGGcGcGGGcAcuAGcuudTsdT sense 430-449 315 AAGCUAGUGCCCGCGCCGG 316
AAGCuAGUGCCCGCGCCGGdTsdT antis 438-457 317 GGCACUAGCUUCCCGCCGC 318
GGcAcuAGcuucccGccGcdTsdT sense 438-457 319 GCGGCGGGAAGCUAGUGCC 320
GCGGCGGGAAGCuAGUGCCdTsdT antis 583-602 321 GAGUAGUAUACCAGGCACG 322
GAGuAGuAuAccAGGcAcGdTsdT sense 583-602 323 CGUGCCUGGUAUACUACUC 324
CGUGCCUGGuAuACuACUCdTsdT antis 654-673 325 AGGUUCAAGAACCGAGAAC 326
AGGuucAAGAAccGAGAAcdTsdT sense 654-673 327 GUUCUCGGUUCUUGAACCU 328
GUUCUCGGUUCUUGAACCUdTsdT antis 667-686 329 GAGAACUGCAGAUUAUGCG 330
GAGAAcuGcAGAuuAuGcGdTsdT sense 667-686 331 CGCAUAAUCUGCAGUUCUC 332
CGcAuAAUCUGcAGUUCUCdTsdT antis 928-947 333 AGCCCCAGAAUUUGCUUGU 334
AGccccAGAAuuuGcuuGudTsdT sense 928-947 335 ACAAGCAAAUUCUGGGGCU 336
AcAAGcAAAUUCUGGGGCUdTsdT antis 994-1013 337 AGCAGCUGGUUCGGGGGGA 338
AGcAGcuGGuucGGGGGGAdTsdT sense 994-1013 339 UCCCCCCGAACCAGCUGCU 340
UCCCCCCGAACcAGCUGCUdTsdT antis 1005-1024 341 CGGGGGGAGCCCAAUGUGU
342 cGGGGGGAGcccAAuGuGudTsdT sense 1005-1024 343
ACACAUUGGGCUCCCCCCG 344 AcAcAUUGGGCUCCCCCCGdTsdT antis 1008-1027
345 GGGGAGCCCAAUGUGUCCU 346 GGGGAGcccAAuGuGuccudTsdT sense
1008-1027 347 AGGACACAUUGGGCUCCCC 348 AGGAcAcAUUGGGCUCCCCdTsdT
antis 1124-1143 349 UGAGCUACUUCUCGGCCAG 350
uGAGcuAcuucucGGccAGdTsdT sense 1124-1143 351 CUGGCCGAGAAGUAGCUCA
352 CUGGCCGAGAAGuAGCUcAdTsdT antis 1303-1322 353
CAAAGACACCACCUGAGGC 354 cAAAGAcAccAccuGAGGcdTsdT sense 1303-1322
355 GCCUCAGGUGGUGUCUUUG 356 GCCUcAGGUGGUGUCUUUGdTsdT antis
1311-1330 357 CCACCUGAGGCCAUUGCAC 358 ccAccuGAGGccAuuGcAcdTsdT
sense 1311-1330 359 GUGCAAUGGCCUCAGGUGG 360
GUGcAAUGGCCUcAGGUGGdTsdT antis 1444-1463 361 GCCCGCUUCCCCCCCUGUU
362 GcccGcuucccccccuGuudTsdT sense 1444-1463 363
AACAGGGGGGGAAGCGGGC 364 AAcAGGGGGGGAAGCGGGCdTsdT antis 1488-1507
365 AUCCAACCAUCUCUCAAUG 366 AuccAAccAucucucAAuGdTsdT sense
1488-1507 367 CAUUGAGAGAUGGUUGGAU 368 cAUUGAGAGAUGGUUGGAUdTsdT
antis 1851-1870 369 AUUUUAACUGUUUGUAGGG 370
AuuuuAAcuGuuuGuAGGGdTsdT sense 1851-1870 371 CCCUACAAACAGUUAAAAU
372 CCCuAcAAAcAGUuAAAAUdTsdT antis 1852-1871 373
UUUUAACUGUUUGUAGGGG 374 uuuuAAcuGuuuGuAGGGGdTsdT sense 1852-1871
375 CCCCUACAAACAGUUAAAA 376 CCCCuAcAAAcAGUuAAAAdTsdT antis
1935-1954 377 CUCCCCCAGGCUACCACUC 378 cucccccAGGcuAccAcucdTsdT
sense 1935-1954 379 GAGUGGUAGCCUGGGGGAG 380
GAGUGGuAGCCUGGGGGAGdTsdT antis 1975-1994 381 GGUCCCUUGUAAAUAGAAC
382 GGucccuuGuAAAuAGAAcdTsdT sense 1975-1994 383
GUUCUAUUUACAAGGGACC 384 GUUCuAUUuAcAAGGGACCdTsdT antis 2029-2048
385 CCCCUGGGUGUAAAUAGAU 386 ccccuGGGuGuAAAuAGAudTsdT sense
2029-2048 387 AUCUAUUUACACCCAGGGG 388 AUCuAUUuAcACCcAGGGGdTsdT
antis 2033-2052 389 UGGGUGUAAAUAGAUUGUU 390
uGGGuGuAAAuAGAuuGuudTsdT sense 2033-2052 391 AACAAUCUAUUUACACCCA
392 AAcAAUCuAUUuAcACCcAdTsdT antis 2062-2081 393
CUUAAAGAAAACGUCAAUU 394 cuuAAAGAAAAcGucAAuudTsdT sense 2062-2081
395 AAUUGACGUUUUCUUUAAG 396 AAUUGACGUUUUCUUuAAGdTsdT antis
2063-2082 397 UUAAAGAAAACGUCAAUUC 398 uuAAAGAAAAcGucAAuucdTsdT
sense 2063-2082 399 GAAUUGACGUUUUCUUUAA 400
GAAUUGACGUUUUCUUuAAdTsdT antis 2078-2097 401 AUUCACACCAUUCAACUUG
402 AuucAcAccAuucAAcuuGdTsdT sense 2078-2097 403
CAAGUUGAAUGGUGUGAAU 404 cAAGUUGAAUGGUGUGAAUdTsdT antis 2082-2101
405 ACACCAUUCAACUUGCCCC 406 AcAccAuucAAcuuGccccdTsdT sense
2082-2101 407 GGGGCAAGUUGAAUGGUGU 408 GGGGcAAGUUGAAUGGUGUdTsdT
antis 2181-2200 409 UCCCUGGUGUCUUAGUUUC 410
ucccuGGuGucuuAGuuucdTsdT sense 2181-2200 411 GAAACUAAGACACCAGGGA
412 GAAACuAAGAcACcAGGGAdTsdT antis 2197-2216 413
UUCCACAGUAAGGUUUGCC 414 uuccAcAGuAAGGuuuGccdTsdT sense 2197-2216
415 GGCAAACCUUACUGUGGAA 416 GGcAAACCUuACUGUGGAAdTsdT antis
2209-2228 417 GUUUGCCUGUGUACAGACC 418 GuuuGccuGuGuAcAGAccdTsdT
sense 2209-2228 419 GGUCUGUACACAGGCAAAC 420
GGUCUGuAcAcAGGcAAACdTsdT antis 2232-2251 421 UUCAAUAAAUUAUUGGCAU
422 uucAAuAAAuuAuuGGcAudTsdT sense 2232-2251 423
AUGCCAAUAAUUUAUUGAA 424 AUGCcAAuAAUUuAUUGAAdTsdT antis 2235-2254
425 AAUAAAUUAUUGGCAUGAA 426 AAuAAAuuAuuGGcAuGAAdTsdT sense
2235-2254 427 UUCAUGCCAAUAAUUUAUU 428 UUcAUGCcAAuAAUUuAUUdTsdT
antis 2243-2262 429 AUUGGCAUGAAACCCUUAA 430
AuuGGcAuGAAAcccuuAAdTsdT sense 2243-2262 431 UUAAGGGUUUCAUGCCAAU
432 UuAAGGGUUUcAUGCcAAUdTsdT antis 336-355 433 GGGAAAGCGUCAGUCGGGG
434 GGGAAAGcGucAGucGGGGdTsdT sense 336-355 435 CCCCGACUGACGCUUUCCC
436 CCCCGACUGACGCUUUCCCdTsdT antis 894-913 437 AUCCACUCCCAAGGUGUGU
438 AuccAcucccAAGGuGuGudTsdT sense 894-913 439 ACACACCUUGGGAGUGGAU
440 AcAcACCUUGGGAGUGGAUdTsdT antis 1070-1089 441
AGCCACAGAUUACACCUCG 442 AGccAcAGAuuAcAccucGdTsdT sense 1070-1089
443 CGAGGUGUAAUCUGUGGCU 444 CGAGGUGuAAUCUGUGGCUdTsdT antis
1346-1365 445 GGAGUACACGCCAUCCUCA 446 GGAGuAcAcGccAuccucAdTsdT
sense 1346-1365 447 UGAGGAUGGCGUGUACUCC 448
UGAGGAUGGCGUGuACUCCdTsdT antis 1976-1995 449 GUCCCUUGUAAAUAGAACC
450 GucccuuGuAAAuAGAAccdTsdT sense 1976-1995 451
GGUUCUAUUUACAAGGGAC 452 GGUUCuAUUuAcAAGGGACdTsdT antis 1977-1996
453 UCCCUUGUAAAUAGAACCA 454 ucccuuGuAAAuAGAAccAdTsdT sense
1977-1996 455 UGGUUCUAUUUACAAGGGA 456 UGGUUCuAUUuAcAAGGGAdTsdT
antis 2194-2213 457 AGUUUCCACAGUAAGGUUU 458
AGuuuccAcAGuAAGGuuudTsdT sense 2194-2213 459 AAACCUUACUGUGGAAACU
460 AAACCUuACUGUGGAAACUdTsdT antis 1229-1248 461
GAUGAACCCUAACUAUACG 462 GAuGAAcccuAAcuAuAcGdTsdT sense 1229-1248
463 CGUAUAGUUAGGGUUCAUC 464 CGuAuAGUuAGGGUUcAUCdTsdT antis 341-360
465 AGCGUCAGUCGGGGCUAUG 466 AGcGucAGucGGGGcuAuGdTsdT sense 341-360
467 CAUAGCCCCGACUGACGCU 468 cAuAGCCCCGACUGACGCUdTsdT antis 574-593
469 GCUCAUUCGGAGUAGUAUA 470 GcucAuucGGAGuAGuAuAdTsdT sense 574-593
471 UAUACUACUCCGAAUGAGC 472 uAuACuACUCCGAAUGAGCdTsdT antis 578-597
473 AUUCGGAGUAGUAUACCAG 474 AuucGGAGuAGuAuAccAGdTsdT sense 578-597
475 CUGGUAUACUACUCCGAAU 476 CUGGuAuACuACUCCGAAUdTsdT antis 672-691
477 CUGCAGAUUAUGCGUAAGC 478 cuGcAGAuuAuGcGuAAGcdTsdT sense 672-691
479 GCUUACGCAUAAUCUGCAG 480 GCUuACGcAuAAUCUGcAGdTsdT antis 673-692
481 UGCAGAUUAUGCGUAAGCU 482 uGcAGAuuAuGcGuAAGcudTsdT sense 673-692
483 AGCUUACGCAUAAUCUGCA 484 AGCUuACGcAuAAUCUGcAdTsdT antis 674-693
485 GCAGAUUAUGCGUAAGCUG 486 GcAGAuuAuGcGuAAGcuGdTsdT sense 674-693
487 CAGCUUACGCAUAAUCUGC 488 cAGCUuACGcAuAAUCUGCdTsdT antis
1433-1452 489 CCCCAACGACCGCCCGCUU 490 ccccAAcGAccGcccGcuudTsdT
sense
1433-1452 491 AAGCGGGCGGUCGUUGGGG 492 AAGCGGGCGGUCGUUGGGGdTsdT
antis 1434-1453 493 CCCAACGACCGCCCGCUUC 494
cccAAcGAccGcccGcuucdTsdT sense 1434-1453 495 GAAGCGGGCGGUCGUUGGG
496 GAAGCGGGCGGUCGUUGGGdTsdT antis 1640-1659 497
UGCUACCCUCGCUAGCUCU 498 uGcuAcccucGcuAGcucudTsdT sense 1640-1659
499 AGAGCUAGCGAGGGUAGCA 500 AGAGCuAGCGAGGGuAGcAdTsdT antis 458-477
501 GGGAGUGAAGCUGGGCCGU 502 GGGAGuGAAGcuGGGccGudTsdT sense 458-477
503 ACGGCCCAGCUUCACUCCC 504 ACGGCCcAGCUUcACUCCCdTsdT antis 459-478
505 GGAGUGAAGCUGGGCCGUG 506 GGAGuGAAGcuGGGccGuGdTsdT sense 459-478
507 CACGGCCCAGCUUCACUCC 508 cACGGCCcAGCUUcACUCCdTsdT antis 573-592
509 GGCUCAUUCGGAGUAGUAU 510 GGcucAuucGGAGuAGuAudTsdT sense 573-592
511 AUACUACUCCGAAUGAGCC 512 AuACuACUCCGAAUGAGCCdTsdT antis 575-594
513 CUCAUUCGGAGUAGUAUAC 514 cucAuucGGAGuAGuAuAcdTsdT sense 575-594
515 GUAUACUACUCCGAAUGAG 516 GuAuACuACUCCGAAUGAGdTsdT antis 576-595
517 UCAUUCGGAGUAGUAUACC 518 ucAuucGGAGuAGuAuAccdTsdT sense 576-595
519 GGUAUACUACUCCGAAUGA 520 GGuAuACuACUCCGAAUGAdTsdT antis 577-596
521 CAUUCGGAGUAGUAUACCA 522 cAuucGGAGuAGuAuAccAdTsdT sense 577-596
523 UGGUAUACUACUCCGAAUG 524 UGGuAuACuACUCCGAAUGdTsdT antis 579-598
525 UUCGGAGUAGUAUACCAGG 526 uucGGAGuAGuAuAccAGGdTsdT sense 579-598
527 CCUGGUAUACUACUCCGAA 528 CCUGGuAuACuACUCCGAAdTsdT antis 671-690
529 ACUGCAGAUUAUGCGUAAG 530 AcuGcAGAuuAuGcGuAAGdTsdT sense 671-690
531 CUUACGCAUAAUCUGCAGU 532 CUuACGcAuAAUCUGcAGUdTsdT antis 786-805
533 CCCGAGACGGUGUACCGAG 534 cccGAGAcGGuGuAccGAGdTsdT sense 786-805
535 CUCGGUACACCGUCUCGGG 536 CUCGGuAcACCGUCUCGGGdTsdT antis 787-806
537 CCGAGACGGUGUACCGAGU 538 ccGAGAcGGuGuAccGAGudTsdT sense 787-806
539 ACUCGGUACACCGUCUCGG 540 ACUCGGuAcACCGUCUCGGdTsdT antis 789-808
541 GAGACGGUGUACCGAGUGG 542 GAGAcGGuGuAccGAGuGGdTsdT sense 789-808
543 CCACUCGGUACACCGUCUC 544 CcACUCGGuAcACCGUCUCdTsdT antis
1065-1084 545 UUUGGAGCCACAGAUUACA 546 uuuGGAGccAcAGAuuAcAdTsdT
sense 1065-1084 547 UGUAAUCUGUGGCUCCAAA 548
UGuAAUCUGUGGCUCcAAAdTsdT antis 1226-1245 549 AGAGAUGAACCCUAACUAU
550 AGAGAuGAAcccuAAcuAudTsdT sense 1226-1245 551
AUAGUUAGGGUUCAUCUCU 552 AuAGUuAGGGUUcAUCUCUdTsdT antis 1228-1247
553 AGAUGAACCCUAACUAUAC 554 AGAuGAAcccuAAcuAuAcdTsdT sense
1228-1247 555 GUAUAGUUAGGGUUCAUCU 556 GuAuAGUuAGGGUUcAUCUdTsdT
antis 1636-1655 557 CAACUGCUACCCUCGCUAG 558
cAAcuGcuAcccucGcuAGdTsdT sense 1636-1655 559 CUAGCGAGGGUAGCAGUUG
560 CuAGCGAGGGuAGcAGUUGdTsdT antis 1639-1658 561
CUGCUACCCUCGCUAGCUC 562 cuGcuAcccucGcuAGcucdTsdT sense 1639-1658
563 GAGCUAGCGAGGGUAGCAG 564 GAGCuAGCGAGGGuAGcAGdTsdT antis
2036-2055 565 GUGUAAAUAGAUUGUUAUA 566 GuGuAAAuAGAuuGuuAuAdTsdT
sense 2036-2055 567 UAUAACAAUCUAUUUACAC 568
uAuAAcAAUCuAUUuAcACdTsdT antis 426-445 569 GGCCCCGGCGCGGGCACUA 570
GGccccGGcGcGGGcAcuAdTsdT sense 426-445 571 UAGUGCCCGCGCCGGGGCC 572
uAGUGCCCGCGCCGGGGCCdTsdT antis 883-902 573 GCUUGGCCUACAUCCACUC 574
GcuuGGccuAcAuccAcucdTsdT sense 883-902 575 GAGUGGAUGUAGGCCAAGC 576
GAGUGGAUGuAGGCcAAGCdTsdT antis 1227-1246 577 GAGAUGAACCCUAACUAUA
578 GAGAuGAAcccuAAcuAuAdTsdT sense 1227-1246 579
UAUAGUUAGGGUUCAUCUC 580 uAuAGUuAGGGUUcAUCUCdTsdT antis 1369-1388
581 UCUCCCCACUCGAGGCUUG 582 ucuccccAcucGAGGcuuGdTsdT sense
1369-1388 583 CAAGCCUCGAGUGGGGAGA 584 cAAGCCUCGAGUGGGGAGAdTsdT
antis 1393-1412 585 ACAGCUUCUUCGAUGAACU 586
AcAGcuucuucGAuGAAcudTsdT sense 1393-1412 587 AGUUCAUCGAAGAAGCUGU
588 AGUUcAUCGAAGAAGCUGUdTsdT antis 1431-1450 589
CUCCCCAACGACCGCCCGC 590 cuccccAAcGAccGcccGcdTsdT sense 1431-1450
591 GCGGGCGGUCGUUGGGGAG 592 GCGGGCGGUCGUUGGGGAGdTsdT antis
1436-1455 593 CAACGACCGCCCGCUUCCC 594 cAAcGAccGcccGcuucccdTsdT
sense 1436-1455 595 GGGAAGCGGGCGGUCGUUG 596
GGGAAGCGGGCGGUCGUUGdTsdT antis 1437-1456 597 AACGACCGCCCGCUUCCCC
598 AAcGAccGcccGcuuccccdTsdT sense 1437-1456 599
GGGGAAGCGGGCGGUCGUU 600 GGGGAAGCGGGCGGUCGUUdTsdT antis 2176-2195
601 GAGAGUCCCUGGUGUCUUA 602 GAGAGucccuGGuGucuuAdTsdT sense
2176-2195 603 UAAGACACCAGGGACUCUC 604 uAAGAcACcAGGGACUCUCdTsdT
antis 599-618 605 ACGGCUGGCAGAGACGAGG 606 AcGGcuGGcAGAGAcGAGGdTsdT
sense 599-618 607 CCUCGUCUCUGCCAGCCGU 608 CCUCGUCUCUGCcAGCCGUdTsdT
antis 706-725 609 UUGUGAGGCUGCGGUACUU 610 uuGuGAGGcuGcGGuAcuudTsdT
sense 706-725 611 AAGUACCGCAGCCUCACAA 612 AAGuACCGcAGCCUcAcAAdTsdT
antis 707-726 613 UGUGAGGCUGCGGUACUUU 614 uGuGAGGcuGcGGuAcuuudTsdT
sense 707-726 615 AAAGUACCGCAGCCUCACA 616 AAAGuACCGcAGCCUcAcAdTsdT
antis 791-810 617 GACGGUGUACCGAGUGGCC 618 GAcGGuGuAccGAGuGGccdTsdT
sense 791-810 619 GGCCACUCGGUACACCGUC 620 GGCcACUCGGuAcACCGUCdTsdT
antis 899-918 621 CUCCCAAGGUGUGUGUCAC 622 cucccAAGGuGuGuGucAcdTsdT
sense 899-918 623 GUGACACACACCUUGGGAG 624 GUGAcAcAcACCUUGGGAGdTsdT
antis 989-1008 625 UGCAAAGCAGCUGGUUCGG 626 uGcAAAGcAGcuGGuucGGdTsdT
sense 989-1008 627 CCGAACCAGCUGCUUUGCA 628 CCGAACcAGCUGCUUUGcAdTsdT
antis 1064-1083 629 CUUUGGAGCCACAGAUUAC 630
cuuuGGAGccAcAGAuuAcdTsdT sense 1064-1083 631 GUAAUCUGUGGCUCCAAAG
632 GuAAUCUGUGGCUCcAAAGdTsdT antis 1066-1085 633
UUGGAGCCACAGAUUACAC 634 uuGGAGccAcAGAuuAcAcdTsdT sense 1066-1085
635 GUGUAAUCUGUGGCUCCAA 636 GUGuAAUCUGUGGCUCcAAdTsdT antis
1125-1144 637 GAGCUACUUCUCGGCCAGC 638 GAGcuAcuucucGGccAGcdTsdT
sense 1125-1144 639 GCUGGCCGAGAAGUAGCUC 640
GCUGGCCGAGAAGuAGCUCdTsdT antis 1225-1244 641 GAGAGAUGAACCCUAACUA
642 GAGAGAuGAAcccuAAcuAdTsdT sense 1225-1244 643
UAGUUAGGGUUCAUCUCUC 644 uAGUuAGGGUUcAUCUCUCdTsdT antis 1265-1284
645 GAUCAAAGCUCACCCUUGG 646 GAucAAAGcucAcccuuGGdTsdT sense
1265-1284 647 CCAAGGGUGAGCUUUGAUC 648 CcAAGGGUGAGCUUUGAUCdTsdT
antis 1269-1288 649 AAAGCUCACCCUUGGACAA 650
AAAGcucAcccuuGGAcAAdTsdT sense 1269-1288 651 UUGUCCAAGGGUGAGCUUU
652 UUGUCcAAGGGUGAGCUUUdTsdT antis 1365-1384 653
AGGCUCUCCCCACUCGAGG 654 AGGcucuccccAcucGAGGdTsdT sense 1365-1384
655 CCUCGAGUGGGGAGAGCCU 656 CCUCGAGUGGGGAGAGCCUdTsdT antis
1481-1500 657 ACUGUCCAUCCAACCAUCU 658 AcuGuccAuccAAccAucudTsdT
sense 1481-1500 659 AGAUGGUUGGAUGGACAGU 660
AGAUGGUUGGAUGGAcAGUdTsdT antis 1637-1656 661 AACUGCUACCCUCGCUAGC
662 AAcuGcuAcccucGcuAGcdTsdT sense 1637-1656 663
GCUAGCGAGGGUAGCAGUU 664 GCuAGCGAGGGuAGcAGUUdTsdT antis 1979-1998
665 CCUUGUAAAUAGAACCAGC 666 ccuuGuAAAuAGAAccAGcdTsdT sense
1979-1998 667 GCUGGUUCUAUUUACAAGG 668 GCUGGUUCuAUUuAcAAGGdTsdT
antis 2196-2215 669 UUUCCACAGUAAGGUUUGC 670
uuuccAcAGuAAGGuuuGcdTsdT sense 2196-2215 671 GCAAACCUUACUGUGGAAA
672 GcAAACCUuACUGUGGAAAdTsdT antis 1978-1997 673
CCCUUGUAAAUAGAACCAG 674 cccuuGuAAAuAGAAccAGdTsdT sense 1978-1997
675 CUGGUUCUAUUUACAAGGG 676 CUGGUUCuAUUuAcAAGGGdTsdT antis 651-670
677 AAAAGGUUCAAGAACCGAG 678 AAAAGGuucAAGAAccGAGdTsdT sense 651-670
679 CUCGGUUCUUGAACCUUUU 680 CUCGGUUCUUGAACCUUUUdTsdT antis 702-721
681 AAUAUUGUGAGGCUGCGGU 682 AAuAuuGuGAGGcuGcGGudTsdT sense 702-721
683 ACCGCAGCCUCACAAUAUU 684 ACCGcAGCCUcAcAAuAUUdTsdT antis
1363-1382 685 CAAGGCUCUCCCCACUCGA 686 cAAGGcucuccccAcucGAdTsdT
sense 1363-1382 687 UCGAGUGGGGAGAGCCUUG 688
UCGAGUGGGGAGAGCCUUGdTsdT antis 701-720 689 CAAUAUUGUGAGGCUGCGG 690
cAAuAuuGuGAGGcuGcGGdTsdT sense 701-720 691 CCGCAGCCUCACAAUAUUG 692
CCGcAGCCUcAcAAuAUUGdTsdT antis 1237-1256 693 CUAACUAUACGGAGUUCAA
694 cuAAcuAuAcGGAGuucAAdTsdT sense 1237-1256 695
UUGAACUCCGUAUAGUUAG 696 UUGAACUCCGuAuAGUuAGdTsdT antis 2064-2083
697 UAAAGAAAACGUCAAUUCA 698 uAAAGAAAAcGucAAuucAdTsdT sense
2064-2083 699 UGAAUUGACGUUUUCUUUA 700 UGAAUUGACGUUUUCUUuAdTsdT
antis 828-847 701 AAGCUGAUCACCCCUAUCA 702 AAGcuGAucAccccuAucAdTsdT
sense 828-847 703 UGAUAGGGGUGAUCAGCUU 704 UGAuAGGGGUGAUcAGCUUdTsdT
antis 930-949 705 CCCCAGAAUUUGCUUGUGG 706 ccccAGAAuuuGcuuGuGGdTsdT
sense 930-949 707 CCACAAGCAAAUUCUGGGG 708 CcAcAAGcAAAUUCUGGGGdTsdT
antis 995-1014 709 GCAGCUGGUUCGGGGGGAG 710 GcAGcuGGuucGGGGGGAGdTsdT
sense 995-1014 711 CUCCCCCCGAACCAGCUGC 712 CUCCCCCCGAACcAGCUGCdTsdT
antis 1478-1497 713 UGAACUGUCCAUCCAACCA 714
uGAAcuGuccAuccAAccAdTsdT sense 1478-1497 715 UGGUUGGAUGGACAGUUCA
716 UGGUUGGAUGGAcAGUUcAdTsdT antis 1604-1623 717
GACUGGCCAAGAUUGGCAG 718 GAcuGGccAAGAuuGGcAGdTsdT sense 1604-1623
719 CUGCCAAUCUUGGCCAGUC 720 CUGCcAAUCUUGGCcAGUCdTsdT antis
1808-1827 721 CUCCCUCAGCAGCCUAACC 722 cucccucAGcAGccuAAccdTsdT
sense 1808-1827 723 GGUUAGGCUGCUGAGGGAG 724
GGUuAGGCUGCUGAGGGAGdTsdT antis 2177-2196 725 AGAGUCCCUGGUGUCUUAG
726 AGAGucccuGGuGucuuAGdTsdT sense 2177-2196 727
CUAAGACACCAGGGACUCU 728 CuAAGAcACcAGGGACUCUdTsdT antis 82-101 729
GAACGGCGCGGCCUGGAAG 730 GAAcGGcGcGGccuGGAAGdTsdT sense 82-101 731
CUUCCAGGCCGCGCCGUUC 732 CUUCcAGGCCGCGCCGUUCdTsdT antis 1077-1096
733 GAUUACACCUCGUCCAUCG 734 GAuuAcAccucGuccAucGdTsdT sense
1077-1096 735 CGAUGGACGAGGUGUAAUC 736 CGAUGGACGAGGUGuAAUCdTsdT
antis 1238-1257 737 UAACUAUACGGAGUUCAAG 738
uAAcuAuAcGGAGuucAAGdTsdT sense 1238-1257 739 CUUGAACUCCGUAUAGUUA
740 CUUGAACUCCGuAuAGUuAdTsdT antis
248-267 741 CAGCUCGUUCGCGGAGCCA 742 cAGcucGuucGcGGAGccAdTsdT sense
248-267 743 UGGCUCCGCGAACGAGCUG 744 UGGCUCCGCGAACGAGCUGdTsdT antis
250-269 745 GCUCGUUCGCGGAGCCAGG 746 GcucGuucGcGGAGccAGGdTsdT sense
250-269 747 CCUGGCUCCGCGAACGAGC 748 CCUGGCUCCGCGAACGAGCdTsdT antis
327-346 749 ACUGGCGGCGGGAAAGCGU 750 AcuGGcGGcGGGAAAGcGudTsdT sense
327-346 751 ACGCUUUCCCGCCGCCAGU 752 ACGCUUUCCCGCCGCcAGUdTsdT antis
332-351 753 CGGCGGGAAAGCGUCAGUC 754 cGGcGGGAAAGcGucAGucdTsdT sense
332-351 755 GACUGACGCUUUCCCGCCG 756 GACUGACGCUUUCCCGCCGdTsdT antis
376-395 757 CCUCGAGCUCCGGGGGUGG 758 ccucGAGcuccGGGGGuGGdTsdT sense
376-395 759 CCACCCCCGGAGCUCGAGG 760 CcACCCCCGGAGCUCGAGGdTsdT antis
468-487 761 CUGGGCCGUGACAGCGGGA 762 cuGGGccGuGAcAGcGGGAdTsdT sense
468-487 763 UCCCGCUGUCACGGCCCAG 764 UCCCGCUGUcACGGCCcAGdTsdT antis
584-603 765 AGUAGUAUACCAGGCACGG 766 AGuAGuAuAccAGGcAcGGdTsdT sense
584-603 767 CCGUGCCUGGUAUACUACU 768 CCGUGCCUGGuAuACuACUdTsdT antis
785-804 769 GCCCGAGACGGUGUACCGA 770 GcccGAGAcGGuGuAccGAdTsdT sense
785-804 771 UCGGUACACCGUCUCGGGC 772 UCGGuAcACCGUCUCGGGCdTsdT antis
1010-1029 773 GGAGCCCAAUGUGUCCUAC 774 GGAGcccAAuGuGuccuAcdTsdT
sense 1010-1029 775 GUAGGACACAUUGGGCUCC 776
GuAGGAcAcAUUGGGCUCCdTsdT antis 1011-1030 777 GAGCCCAAUGUGUCCUACA
778 GAGcccAAuGuGuccuAcAdTsdT sense 1011-1030 779
UGUAGGACACAUUGGGCUC 780 UGuAGGAcAcAUUGGGCUCdTsdT antis 1021-1040
781 UGUCCUACAUCUGCUCUCG 782 uGuccuAcAucuGcucucGdTsdT sense
1021-1040 783 CGAGAGCAGAUGUAGGACA 784 CGAGAGcAGAUGuAGGAcAdTsdT
antis 1022-1041 785 GUCCUACAUCUGCUCUCGG 786
GuccuAcAucuGcucucGGdTsdT sense 1022-1041 787 CCGAGAGCAGAUGUAGGAC
788 CCGAGAGcAGAUGuAGGACdTsdT antis 1023-1042 789
UCCUACAUCUGCUCUCGGU 790 uccuAcAucuGcucucGGudTsdT sense 1023-1042
791 ACCGAGAGCAGAUGUAGGA 792 ACCGAGAGcAGAUGuAGGAdTsdT antis
1072-1091 793 CCACAGAUUACACCUCGUC 794 ccAcAGAuuAcAccucGucdTsdT
sense 1072-1091 795 GACGAGGUGUAAUCUGUGG 796
GACGAGGUGuAAUCUGUGGdTsdT antis 1127-1146 797 GCUACUUCUCGGCCAGCCC
798 GcuAcuucucGGccAGcccdTsdT sense 1127-1146 799
GGGCUGGCCGAGAAGUAGC 800 GGGCUGGCCGAGAAGuAGCdTsdT antis 1408-1427
801 AACUGCGGAGACUCGGAGC 802 AAcuGcGGAGAcucGGAGcdTsdT sense
1408-1427 803 GCUCCGAGUCUCCGCAGUU 804 GCUCCGAGUCUCCGcAGUUdTsdT
antis 1432-1451 805 UCCCCAACGACCGCCCGCU 806
uccccAAcGAccGcccGcudTsdT sense 1432-1451 807 AGCGGGCGGUCGUUGGGGA
808 AGCGGGCGGUCGUUGGGGAdTsdT antis 1982-2001 809
UGUAAAUAGAACCAGCCCA 810 uGuAAAuAGAAccAGcccAdTsdT sense 1982-2001
811 UGGGCUGGUUCUAUUUACA 812 UGGGCUGGUUCuAUUuAcAdTsdT antis
2030-2049 813 CCCUGGGUGUAAAUAGAUU 814 cccuGGGuGuAAAuAGAuudTsdT
sense 2030-2049 815 AAUCUAUUUACACCCAGGG 816
AAUCuAUUuAcACCcAGGGdTsdT antis 2073-2092 817 CGUCAAUUCACACCAUUCA
818 cGucAAuucAcAccAuucAdTsdT sense 2073-2092 819
UGAAUGGUGUGAAUUGACG 820 UGAAUGGUGUGAAUUGACGdTsdT antis 2218-2237
821 UGUACAGACCUCUGUUCAA 822 uGuAcAGAccucuGuucAAdTsdT sense
2218-2237 823 UUGAACAGAGGUCUGUACA 824 UUGAAcAGAGGUCUGuAcAdTsdT
antis 2229-2248 825 CUGUUCAAUAAAUUAUUGG 826
cuGuucAAuAAAuuAuuGGdTsdT sense 2229-2248 827 CCAAUAAUUUAUUGAACAG
828 CcAAuAAUUuAUUGAAcAGdTsdT antis 7-26 829 ACAACGAAGCCGACGGCAG 830
AcAAcGAAGccGAcGGcAGdTsdT sense 7-26 831 CUGCCGUCGGCUUCGUUGU 832
CUGCCGUCGGCUUCGUUGUdTsdT antis 8-27 833 CAACGAAGCCGACGGCAGA 834
cAAcGAAGccGAcGGcAGAdTsdT sense 8-27 835 UCUGCCGUCGGCUUCGUUG 836
UCUGCCGUCGGCUUCGUUGdTsdT antis 76-95 837 GAGCCCGAACGGCGCGGCC 838
GAGcccGAAcGGcGcGGccdTsdT sense 76-95 839 GGCCGCGCCGUUCGGGCUC 840
GGCCGCGCCGUUCGGGCUCdTsdT antis 176-195 841 GCCUGCGCUCGGCGCCAUG 842
GccuGcGcucGGcGccAuGdTsdT sense 176-195 843 CAUGGCGCCGAGCGCAGGC 844
cAUGGCGCCGAGCGcAGGCdTsdT antis 434-453 845 CGCGGGCACUAGCUUCCCG 846
cGcGGGcAcuAGcuucccGdTsdT sense 434-453 847 CGGGAAGCUAGUGCCCGCG 848
CGGGAAGCuAGUGCCCGCGdTsdT antis 472-491 849 GCCGUGACAGCGGGAAGGU 850
GccGuGAcAGcGGGAAGGudTsdT sense 472-491 851 ACCUUCCCGCUGUCACGGC 852
ACCUUCCCGCUGUcACGGCdTsdT antis 537-556 853 GAAGUGGCUUACACUGACA 854
GAAGuGGcuuAcAcuGAcAdTsdT sense 537-556 855 UGUCAGUGUAAGCCACUUC 856
UGUcAGUGuAAGCcACUUCdTsdT antis 656-675 857 GUUCAAGAACCGAGAACUG 858
GuucAAGAAccGAGAAcuGdTsdT sense 656-675 859 CAGUUCUCGGUUCUUGAAC 860
cAGUUCUCGGUUCUUGAACdTsdT antis 657-676 861 UUCAAGAACCGAGAACUGC 862
uucAAGAAccGAGAAcuGcdTsdT sense 657-676 863 GCAGUUCUCGGUUCUUGAA 864
GcAGUUCUCGGUUCUUGAAdTsdT antis 784-803 865 UGCCCGAGACGGUGUACCG 866
uGcccGAGAcGGuGuAccGdTsdT sense 784-803 867 CGGUACACCGUCUCGGGCA 868
CGGuAcACCGUCUCGGGcAdTsdT antis 1404-1423 869 GAUGAACUGCGGAGACUCG
870 GAuGAAcuGcGGAGAcucGdTsdT sense 1404-1423 871
CGAGUCUCCGCAGUUCAUC 872 CGAGUCUCCGcAGUUcAUCdTsdT antis 1405-1424
873 AUGAACUGCGGAGACUCGG 874 AuGAAcuGcGGAGAcucGGdTsdT sense
1405-1424 875 CCGAGUCUCCGCAGUUCAU 876 CCGAGUCUCCGcAGUUcAUdTsdT
antis 1445-1464 877 CCCGCUUCCCCCCCUGUUC 878
cccGcuucccccccuGuucdTsdT sense 1445-1464 879 GAACAGGGGGGGAAGCGGG
880 GAAcAGGGGGGGAAGCGGGdTsdT antis 1446-1465 881
CCGCUUCCCCCCCUGUUCA 882 ccGcuucccccccuGuucAdTsdT sense 1446-1465
883 UGAACAGGGGGGGAAGCGG 884 UGAAcAGGGGGGGAAGCGGdTsdT antis
1470-1489 885 AGUCCUGGUGAACUGUCCA 886 AGuccuGGuGAAcuGuccAdTsdT
sense 1470-1489 887 UGGACAGUUCACCAGGACU 888
UGGAcAGUUcACcAGGACUdTsdT antis 1897-1916 889 GGGGGUGUGAGGACCUUCU
890 GGGGGuGuGAGGAccuucudTsdT sense 1897-1916 891
AGAAGGUCCUCACACCCCC 892 AGAAGGUCCUcAcACCCCCdTsdT antis 1937-1956
893 CCCCCAGGCUACCACUCCU 894 cccccAGGcuAccAcuccudTsdT sense
1937-1956 895 AGGAGUGGUAGCCUGGGGG 896 AGGAGUGGuAGCCUGGGGGdTsdT
antis 1981-2000 897 UUGUAAAUAGAACCAGCCC 898
uuGuAAAuAGAAccAGcccdTsdT sense 1981-2000 899 GGGCUGGUUCUAUUUACAA
900 GGGCUGGUUCuAUUuAcAAdTsdT antis 1985-2004 901
AAAUAGAACCAGCCCAGCC 902 AAAuAGAAccAGcccAGccdTsdT sense 1985-2004
903 GGCUGGGCUGGUUCUAUUU 904 GGCUGGGCUGGUUCuAUUUdTsdT antis
2061-2080 905 UCUUAAAGAAAACGUCAAU 906 ucuuAAAGAAAAcGucAAudTsdT
sense 2061-2080 907 AUUGACGUUUUCUUUAAGA 908
AUUGACGUUUUCUUuAAGAdTsdT antis 2065-2084 909 AAAGAAAACGUCAAUUCAC
910 AAAGAAAAcGucAAuucAcdTsdT sense 2065-2084 911
GUGAAUUGACGUUUUCUUU 912 GUGAAUUGACGUUUUCUUUdTsdT antis 1-20 913
GUGGUGACAACGAAGCCGA 914 GuGGuGAcAAcGAAGccGAdTsdT sense 1-20 915
UCGGCUUCGUUGUCACCAC 916 UCGGCUUCGUUGUcACcACdTsdT antis 11-30 917
CGAAGCCGACGGCAGAGGG 918 cGAAGccGAcGGcAGAGGGdTsdT sense 11-30 919
CCCUCUGCCGUCGGCUUCG 920 CCCUCUGCCGUCGGCUUCGdTsdT antis 70-89 921
GAGCCGGAGCCCGAACGGC 922 GAGccGGAGcccGAAcGGcdTsdT sense 70-89 923
GCCGUUCGGGCUCCGGCUC 924 GCCGUUCGGGCUCCGGCUCdTsdT antis 73-92 925
CCGGAGCCCGAACGGCGCG 926 ccGGAGcccGAAcGGcGcGdTsdT sense 73-92 927
CGCGCCGUUCGGGCUCCGG 928 CGCGCCGUUCGGGCUCCGGdTsdT antis 150-169 929
CAGGCAGCCCGAGCCCCGC 930 cAGGcAGcccGAGccccGcdTsdT sense 150-169 931
GCGGGGCUCGGGCUGCCUG 932 GCGGGGCUCGGGCUGCCUGdTsdT antis 178-197 933
CUGCGCUCGGCGCCAUGAG 934 cuGcGcucGGcGccAuGAGdTsdT sense 178-197 935
CUCAUGGCGCCGAGCGCAG 936 CUcAUGGCGCCGAGCGcAGdTsdT antis 180-199 937
GCGCUCGGCGCCAUGAGCG 938 GcGcucGGcGccAuGAGcGdTsdT sense 180-199 939
CGCUCAUGGCGCCGAGCGC 940 CGCUcAUGGCGCCGAGCGCdTsdT antis 196-215 941
GCGGCGGCGGGCCUUCGGG 942 GcGGcGGcGGGccuucGGGdTsdT sense 196-215 943
CCCGAAGGCCCGCCGCCGC 944 CCCGAAGGCCCGCCGCCGCdTsdT antis 202-221 945
GCGGGCCUUCGGGAGGCGG 946 GcGGGccuucGGGAGGcGGdTsdT sense 202-221 947
CCGCCUCCCGAAGGCCCGC 948 CCGCCUCCCGAAGGCCCGCdTsdT antis 223-242 949
CUGGGGGCUCGGGCCGGGC 950 cuGGGGGcucGGGccGGGcdTsdT sense 223-242 951
GCCCGGCCCGAGCCCCCAG 952 GCCCGGCCCGAGCCCCcAGdTsdT antis 238-257 953
GGGCGCGGACCAGCUCGUU 954 GGGcGcGGAccAGcucGuudTsdT sense 238-257 955
AACGAGCUGGUCCGCGCCC 956 AACGAGCUGGUCCGCGCCCdTsdT antis 317-336 957
CCCAGGAGGCACUGGCGGC 958 cccAGGAGGcAcuGGcGGcdTsdT sense 317-336 959
GCCGCCAGUGCCUCCUGGG 960 GCCGCcAGUGCCUCCUGGGdTsdT antis 337-356 961
GGAAAGCGUCAGUCGGGGC 962 GGAAAGcGucAGucGGGGcdTsdT sense 337-356 963
GCCCCGACUGACGCUUUCC 964 GCCCCGACUGACGCUUUCCdTsdT antis 436-455 965
CGGGCACUAGCUUCCCGCC 966 cGGGcAcuAGcuucccGccdTsdT sense 436-455 967
GGCGGGAAGCUAGUGCCCG 968 GGCGGGAAGCuAGUGCCCGdTsdT antis 449-468 969
CCCGCCGCCGGGAGUGAAG 970 cccGccGccGGGAGuGAAGdTsdT sense 449-468 971
CUUCACUCCCGGCGGCGGG 972 CUUcACUCCCGGCGGCGGGdTsdT antis 464-483 973
GAAGCUGGGCCGUGACAGC 974 GAAGcuGGGccGuGAcAGcdTsdT sense 464-483 975
GCUGUCACGGCCCAGCUUC 976 GCUGUcACGGCCcAGCUUCdTsdT antis 534-553 977
CAAGAAGUGGCUUACACUG 978 cAAGAAGuGGcuuAcAcuGdTsdT sense 534-553 979
CAGUGUAAGCCACUUCUUG 980 cAGUGuAAGCcACUUCUUGdTsdT antis 535-554 981
AAGAAGUGGCUUACACUGA 982 AAGAAGuGGcuuAcAcuGAdTsdT sense 535-554 983
UCAGUGUAAGCCACUUCUU 984 UcAGUGuAAGCcACUUCUUdTsdT antis 536-555 985
AGAAGUGGCUUACACUGAC 986 AGAAGuGGcuuAcAcuGAcdTsdT sense 536-555 987
GUCAGUGUAAGCCACUUCU 988 GUcAGUGuAAGCcACUUCUdTsdT antis 821-840 989
CAAGGCCAAGCUGAUCACC 990 cAAGGccAAGcuGAucAccdTsdT sense 821-840 991
GGUGAUCAGCUUGGCCUUG 992 GGUGAUcAGCUUGGCCUUGdTsdT antis
826-845 993 CCAAGCUGAUCACCCCUAU 994 ccAAGcuGAucAccccuAudTsdT sense
826-845 995 AUAGGGGUGAUCAGCUUGG 996 AuAGGGGUGAUcAGCUUGGdTsdT antis
897-916 997 CACUCCCAAGGUGUGUGUC 998 cAcucccAAGGuGuGuGucdTsdT sense
897-916 999 GACACACACCUUGGGAGUG 1000 GAcAcAcACCUUGGGAGUGdTsdT antis
898-917 1001 ACUCCCAAGGUGUGUGUCA 1002 AcucccAAGGuGuGuGucAdTsdT
sense 898-917 1003 UGACACACACCUUGGGAGU 1004
UGAcAcAcACCUUGGGAGUdTsdT antis 990-1009 1005 GCAAAGCAGCUGGUUCGGG
1006 GcAAAGcAGcuGGuucGGGdTsdT sense 990-1009 1007
CCCGAACCAGCUGCUUUGC 1008 CCCGAACcAGCUGCUUUGCdTsdT antis 992-1011
1009 AAAGCAGCUGGUUCGGGGG 1010 AAAGcAGcuGGuucGGGGGdTsdT sense
992-1011 1011 CCCCCGAACCAGCUGCUUU 1012 CCCCCGAACcAGCUGCUUUdTsdT
antis 996-1015 1013 CAGCUGGUUCGGGGGGAGC 1014
cAGcuGGuucGGGGGGAGcdTsdT sense 996-1015 1015 GCUCCCCCCGAACCAGCUG
1016 GCUCCCCCCGAACcAGCUGdTsdT antis 1007-1026 1017
GGGGGAGCCCAAUGUGUCC 1018 GGGGGAGcccAAuGuGuccdTsdT sense 1007-1026
1019 GGACACAUUGGGCUCCCCC 1020 GGAcAcAUUGGGCUCCCCCdTsdT antis
1013-1032 1021 GCCCAAUGUGUCCUACAUC 1022 GcccAAuGuGuccuAcAucdTsdT
sense 1013-1032 1023 GAUGUAGGACACAUUGGGC 1024
GAUGuAGGAcAcAUUGGGCdTsdT antis 1030-1049 1025 UCUGCUCUCGGUACUACCG
1026 ucuGcucucGGuAcuAccGdTsdT sense 1030-1049 1027
CGGUAGUACCGAGAGCAGA 1028 CGGuAGuACCGAGAGcAGAdTsdT antis 1104-1123
1029 UCGGCUGGCUGUGUACUUG 1030 ucGGcuGGcuGuGuAcuuGdTsdT sense
1104-1123 1031 CAAGUACACAGCCAGCCGA 1032 cAAGuAcAcAGCcAGCCGAdTsdT
antis 1109-1128 1033 UGGCUGUGUACUUGCUGAG 1034
uGGcuGuGuAcuuGcuGAGdTsdT sense 1109-1128 1035 CUCAGCAAGUACACAGCCA
1036 CUcAGcAAGuAcAcAGCcAdTsdT antis 1120-1139 1037
UUGCUGAGCUACUUCUCGG 1038 uuGcuGAGcuAcuucucGGdTsdT sense 1120-1139
1039 CCGAGAAGUAGCUCAGCAA 1040 CCGAGAAGuAGCUcAGcAAdTsdT antis
1122-1141 1041 GCUGAGCUACUUCUCGGCC 1042 GcuGAGcuAcuucucGGccdTsdT
sense 1122-1141 1043 GGCCGAGAAGUAGCUCAGC 1044
GGCCGAGAAGuAGCUcAGCdTsdT antis 1266-1285 1045 AUCAAAGCUCACCCUUGGA
1046 AucAAAGcucAcccuuGGAdTsdT sense 1266-1285 1047
UCCAAGGGUGAGCUUUGAU 1048 UCcAAGGGUGAGCUUUGAUdTsdT antis 1329-1348
1049 CUCUGCUCUAGCCUACUGG 1050 cucuGcucuAGccuAcuGGdTsdT sense
1329-1348 1051 CCAGUAGGCUAGAGCAGAG 1052 CcAGuAGGCuAGAGcAGAGdTsdT
antis 1343-1362 1053 ACUGGAGUACACGCCAUCC 1054
AcuGGAGuAcAcGccAuccdTsdT sense 1343-1362 1055 GGAUGGCGUGUACUCCAGU
1056 GGAUGGCGUGuACUCcAGUdTsdT antis 1364-1383 1057
AAGGCUCUCCCCACUCGAG 1058 AAGGcucuccccAcucGAGdTsdT sense 1364-1383
1059 CUCGAGUGGGGAGAGCCUU 1060 CUCGAGUGGGGAGAGCCUUdTsdT antis
1411-1430 1061 UGCGGAGACUCGGAGCCCA 1062 uGcGGAGAcucGGAGcccAdTsdT
sense 1411-1430 1063 UGGGCUCCGAGUCUCCGCA 1064
UGGGCUCCGAGUCUCCGcAdTsdT antis 1570-1589 1065 ACAACCCAUCCUCACAAGC
1066 AcAAcccAuccucAcAAGcdTsdT sense 1570-1589 1067
GCUUGUGAGGAUGGGUUGU 1068 GCUUGUGAGGAUGGGUUGUdTsdT antis 1589-1608
1069 UUUAACUGAAGCUCAGACU 1070 uuuAAcuGAAGcucAGAcudTsdT sense
1589-1608 1071 AGUCUGAGCUUCAGUUAAA 1072 AGUCUGAGCUUcAGUuAAAdTsdT
antis 1609-1628 1073 GCCAAGAUUGGCAGCCAUC 1074
GccAAGAuuGGcAGccAucdTsdT sense 1609-1628 1075 GAUGGCUGCCAAUCUUGGC
1076 GAUGGCUGCcAAUCUUGGCdTsdT antis 1613-1632 1077
AGAUUGGCAGCCAUCUGAU 1078 AGAuuGGcAGccAucuGAudTsdT sense 1613-1632
1079 AUCAGAUGGCUGCCAAUCU 1080 AUcAGAUGGCUGCcAAUCUdTsdT antis
1615-1634 1081 AUUGGCAGCCAUCUGAUGC 1082 AuuGGcAGccAucuGAuGcdTsdT
sense 1615-1634 1083 GCAUCAGAUGGCUGCCAAU 1084
GcAUcAGAUGGCUGCcAAUdTsdT antis 1809-1828 1085 UCCCUCAGCAGCCUAACCU
1086 ucccucAGcAGccuAAccudTsdT sense 1809-1828 1087
AGGUUAGGCUGCUGAGGGA 1088 AGGUuAGGCUGCUGAGGGAdTsdT antis 1844-1863
1089 AAAGAGGAUUUUAACUGUU 1090 AAAGAGGAuuuuAAcuGuudTsdT sense
1844-1863 1091 AACAGUUAAAAUCCUCUUU 1092 AAcAGUuAAAAUCCUCUUUdTsdT
antis 1847-1866 1093 GAGGAUUUUAACUGUUUGU 1094
GAGGAuuuuAAcuGuuuGudTsdT sense 1847-1866 1095 ACAAACAGUUAAAAUCCUC
1096 AcAAAcAGUuAAAAUCCUCdTsdT antis 1853-1872 1097
UUUAACUGUUUGUAGGGGA 1098 uuuAAcuGuuuGuAGGGGAdTsdT sense 1853-1872
1099 UCCCCUACAAACAGUUAAA 1100 UCCCCuAcAAAcAGUuAAAdTsdT antis
1857-1876 1101 ACUGUUUGUAGGGGAGGGG 1102 AcuGuuuGuAGGGGAGGGGdTsdT
sense 1857-1876 1103 CCCCUCCCCUACAAACAGU 1104
CCCCUCCCCuAcAAAcAGUdTsdT antis 1896-1915 1105 UGGGGGUGUGAGGACCUUC
1106 uGGGGGuGuGAGGAccuucdTsdT sense 1896-1915 1107
GAAGGUCCUCACACCCCCA 1108 GAAGGUCCUcAcACCCCcAdTsdT antis 1936-1955
1109 UCCCCCAGGCUACCACUCC 1110 ucccccAGGcuAccAcuccdTsdT sense
1936-1955 1111 GGAGUGGUAGCCUGGGGGA 1112 GGAGUGGuAGCCUGGGGGAdTsdT
antis 1967-1986 1113 CUCUCCCAGGUCCCUUGUA 1114
cucucccAGGucccuuGuAdTsdT sense 1967-1986 1115 UACAAGGGACCUGGGAGAG
1116 uAcAAGGGACCUGGGAGAGdTsdT antis 1997-2016 1117
CCCAGCCCAUCUCUCGUCU 1118 cccAGcccAucucucGucudTsdT sense 1997-2016
1119 AGACGAGAGAUGGGCUGGG 1120 AGACGAGAGAUGGGCUGGGdTsdT antis
2001-2020 1121 GCCCAUCUCUCGUCUUCCC 1122 GcccAucucucGucuucccdTsdT
sense 2001-2020 1123 GGGAAGACGAGAGAUGGGC 1124
GGGAAGACGAGAGAUGGGCdTsdT antis 2074-2093 1125 GUCAAUUCACACCAUUCAA
1126 GucAAuucAcAccAuucAAdTsdT sense 2074-2093 1127
UUGAAUGGUGUGAAUUGAC 1128 UUGAAUGGUGUGAAUUGACdTsdT antis 2093-2112
1129 CUUGCCCCCCCCAGCUGUA 1130 cuuGccccccccAGcuGuAdTsdT sense
2093-2112 1131 UACAGCUGGGGGGGGCAAG 1132 uAcAGCUGGGGGGGGcAAGdTsdT
antis 2164-2183 1133 GAGGGGAGUAGAGAGAGUC 1134
GAGGGGAGuAGAGAGAGucdTsdT sense 2164-2183 1135 GACUCUCUCUACUCCCCUC
1136 GACUCUCUCuACUCCCCUCdTsdT antis 2168-2187 1137
GGAGUAGAGAGAGUCCCUG 1138 GGAGuAGAGAGAGucccuGdTsdT sense 2168-2187
1139 CAGGGACUCUCUCUACUCC 1140 cAGGGACUCUCUCuACUCCdTsdT antis
2185-2204 1141 UGGUGUCUUAGUUUCCACA 1142 uGGuGucuuAGuuuccAcAdTsdT
sense 2185-2204 1143 UGUGGAAACUAAGACACCA 1144
UGUGGAAACuAAGAcACcAdTsdT antis 2191-2210 1145 CUUAGUUUCCACAGUAAGG
1146 cuuAGuuuccAcAGuAAGGdTsdT sense 2191-2210 1147
CCUUACUGUGGAAACUAAG 1148 CCUuACUGUGGAAACuAAGdTsdT antis 2202-2221
1149 CAGUAAGGUUUGCCUGUGU 1150 cAGuAAGGuuuGccuGuGudTsdT sense
2202-2221 1151 ACACAGGCAAACCUUACUG 1152 AcAcAGGcAAACCUuACUGdTsdT
antis 2242-2261 1153 UAUUGGCAUGAAACCCUUA 1154
uAuuGGcAuGAAAcccuuAdTsdT sense 2242-2261 1155 UAAGGGUUUCAUGCCAAUA
1156 uAAGGGUUUcAUGCcAAuAdTsdT antis 388-407 1157
GGGGUGGCCCCAGCGGCAG 1158 GGGGuGGccccAGcGGcAGdTsdT sense 388-407
1159 CUGCCGCUGGGGCCACCCC 1160 CUGCCGCUGGGGCcACCCCdTsdT antis
425-444 1161 UGGCCCCGGCGCGGGCACU 1162 uGGccccGGcGcGGGcAcudTsdT
sense 425-444 1163 AGUGCCCGCGCCGGGGCCA 1164
AGUGCCCGCGCCGGGGCcAdTsdT antis 2163-2182 1165 GGAGGGGAGUAGAGAGAGU
1166 GGAGGGGAGuAGAGAGAGudTsdT sense 2163-2182 1167
ACUCUCUCUACUCCCCUCC 1168 ACUCUCUCuACUCCCCUCCdTsdT antis 3-22 1169
GGUGACAACGAAGCCGACG 1170 GGuGAcAAcGAAGccGAcGdTsdT sense 3-22 1171
CGUCGGCUUCGUUGUCACC 1172 CGUCGGCUUCGUUGUcACCdTsdT antis 12-31 1173
GAAGCCGACGGCAGAGGGA 1174 GAAGccGAcGGcAGAGGGAdTsdT sense 12-31 1175
UCCCUCUGCCGUCGGCUUC 1176 UCCCUCUGCCGUCGGCUUCdTsdT antis 72-91 1177
GCCGGAGCCCGAACGGCGC 1178 GccGGAGcccGAAcGGcGcdTsdT sense 72-91 1179
GCGCCGUUCGGGCUCCGGC 1180 GCGCCGUUCGGGCUCCGGCdTsdT antis 90-109 1181
CGGCCUGGAAGAGGCCGGA 1182 cGGccuGGAAGAGGccGGAdTsdT sense 90-109 1183
UCCGGCCUCUUCCAGGCCG 1184 UCCGGCCUCUUCcAGGCCGdTsdT antis 316-335
1185 GCCCAGGAGGCACUGGCGG 1186 GcccAGGAGGcAcuGGcGGdTsdT sense
316-335 1187 CCGCCAGUGCCUCCUGGGC 1188 CCGCcAGUGCCUCCUGGGCdTsdT
antis 335-354 1189 CGGGAAAGCGUCAGUCGGG 1190
cGGGAAAGcGucAGucGGGdTsdT sense 335-354 1191 CCCGACUGACGCUUUCCCG
1192 CCCGACUGACGCUUUCCCGdTsdT antis 466-485 1193
AGCUGGGCCGUGACAGCGG 1194 AGcuGGGccGuGAcAGcGGdTsdT sense 466-485
1195 CCGCUGUCACGGCCCAGCU 1196 CCGCUGUcACGGCCcAGCUdTsdT antis
489-508 1197 GUGACCACAGUGGUAGCCA 1198 GuGAccAcAGuGGuAGccAdTsdT
sense 489-508 1199 UGGCUACCACUGUGGUCAC 1200
UGGCuACcACUGUGGUcACdTsdT antis 708-727 1201 GUGAGGCUGCGGUACUUUU
1202 GuGAGGcuGcGGuAcuuuudTsdT sense 708-727 1203
AAAAGUACCGCAGCCUCAC 1204 AAAAGuACCGcAGCCUcACdTsdT antis 1098-1117
1205 GUGUGGUCGGCUGGCUGUG 1206 GuGuGGucGGcuGGcuGuGdTsdT sense
1098-1117 1207 CACAGCCAGCCGACCACAC 1208 cAcAGCcAGCCGACcAcACdTsdT
antis 1117-1136 1209 UACUUGCUGAGCUACUUCU 1210
uAcuuGcuGAGcuAcuucudTsdT sense 1117-1136 1211 AGAAGUAGCUCAGCAAGUA
1212 AGAAGuAGCUcAGcAAGuAdTsdT antis 1305-1324 1213
AAGACACCACCUGAGGCCA 1214 AAGAcAccAccuGAGGccAdTsdT sense 1305-1324
1215 UGGCCUCAGGUGGUGUCUU 1216 UGGCCUcAGGUGGUGUCUUdTsdT antis
1341-1360 1217 CUACUGGAGUACACGCCAU 1218 cuAcuGGAGuAcAcGccAudTsdT
sense 1341-1360 1219 AUGGCGUGUACUCCAGUAG 1220
AUGGCGUGuACUCcAGuAGdTsdT antis 1345-1364 1221 UGGAGUACACGCCAUCCUC
1222 uGGAGuAcAcGccAuccucdTsdT sense 1345-1364 1223
GAGGAUGGCGUGUACUCCA 1224 GAGGAUGGCGUGuACUCcAdTsdT antis 1811-1830
1225 CCUCAGCAGCCUAACCUCU 1226 ccucAGcAGccuAAccucudTsdT sense
1811-1830 1227 AGAGGUUAGGCUGCUGAGG 1228 AGAGGUuAGGCUGCUGAGGdTsdT
antis 1850-1869 1229 GAUUUUAACUGUUUGUAGG 1230
GAuuuuAAcuGuuuGuAGGdTsdT sense 1850-1869 1231 CCUACAAACAGUUAAAAUC
1232 CCuAcAAAcAGUuAAAAUCdTsdT antis 1969-1988 1233
CUCCCAGGUCCCUUGUAAA 1234 cucccAGGucccuuGuAAAdTsdT sense 1969-1988
1235 UUUACAAGGGACCUGGGAG 1236 UUuAcAAGGGACCUGGGAGdTsdT antis
2162-2181 1237 AGGAGGGGAGUAGAGAGAG 1238 AGGAGGGGAGuAGAGAGAGdTsdT
sense 2162-2181 1239 CUCUCUCUACUCCCCUCCU 1240
CUCUCUCuACUCCCCUCCUdTsdT antis 2195-2214 1241 GUUUCCACAGUAAGGUUUG
1242 GuuuccAcAGuAAGGuuuGdTsdT sense
2195-2214 1243 CAAACCUUACUGUGGAAAC 1244 cAAACCUuACUGUGGAAACdTsdT
antis 1239-1258 1245 AACUAUACGGAGUUCAAGU 1246
AAcuAuAcGGAGuucAAGudTsdT sense 1239-1258 1247 ACUUGAACUCCGUAUAGUU
1248 ACUUGAACUCCGuAuAGUUdTsdT antis 1240-1259 1249
ACUAUACGGAGUUCAAGUU 1250 AcuAuAcGGAGuucAAGuudTsdT sense 1240-1259
1251 AACUUGAACUCCGUAUAGU 1252 AACUUGAACUCCGuAuAGUdTsdT antis 80-99
1253 CCGAACGGCGCGGCCUGGA 1254 ccGAAcGGcGcGGccuGGAdTsdT sense 80-99
1255 UCCAGGCCGCGCCGUUCGG 1256 UCcAGGCCGCGCCGUUCGGdTsdT antis
745-764 1257 AGAAGGACGAGCUGUAUUU 1258 AGAAGGAcGAGcuGuAuuudTsdT
sense 745-764 1259 AAAUACAGCUCGUCCUUCU 1260
AAAuAcAGCUCGUCCUUCUdTsdT antis 1078-1097 1261 AUUACACCUCGUCCAUCGA
1262 AuuAcAccucGuccAucGAdTsdT sense 1078-1097 1263
UCGAUGGACGAGGUGUAAU 1264 UCGAUGGACGAGGUGuAAUdTsdT antis 2071-2090
1265 AACGUCAAUUCACACCAUU 1266 AAcGucAAuucAcAccAuudTsdT sense
2071-2090 1267 AAUGGUGUGAAUUGACGUU 1268 AAUGGUGUGAAUUGACGUUdTsdT
antis 15-34 1269 GCCGACGGCAGAGGGACUU 1270 GccGAcGGcAGAGGGAcuudTsdT
sense 15-34 1271 AAGUCCCUCUGCCGUCGGC 1272 AAGUCCCUCUGCCGUCGGCdTsdT
antis 77-96 1273 AGCCCGAACGGCGCGGCCU 1274 AGcccGAAcGGcGcGGccudTsdT
sense 77-96 1275 AGGCCGCGCCGUUCGGGCU 1276 AGGCCGCGCCGUUCGGGCUdTsdT
antis 182-201 1277 GCUCGGCGCCAUGAGCGGC 1278
GcucGGcGccAuGAGcGGcdTsdT sense 182-201 1279 GCCGCUCAUGGCGCCGAGC
1280 GCCGCUcAUGGCGCCGAGCdTsdT antis 659-678 1281
CAAGAACCGAGAACUGCAG 1282 cAAGAAccGAGAAcuGcAGdTsdT sense 659-678
1283 CUGCAGUUCUCGGUUCUUG 1284 CUGcAGUUCUCGGUUCUUGdTsdT antis
788-807 1285 CGAGACGGUGUACCGAGUG 1286 cGAGAcGGuGuAccGAGuGdTsdT
sense 788-807 1287 CACUCGGUACACCGUCUCG 1288
cACUCGGuAcACCGUCUCGdTsdT antis 1002-1021 1289 GUUCGGGGGGAGCCCAAUG
1290 GuucGGGGGGAGcccAAuGdTsdT sense 1002-1021 1291
CAUUGGGCUCCCCCCGAAC 1292 cAUUGGGCUCCCCCCGAACdTsdT antis 1333-1352
1293 GCUCUAGCCUACUGGAGUA 1294 GcucuAGccuAcuGGAGuAdTsdT sense
1333-1352 1295 UACUCCAGUAGGCUAGAGC 1296 uACUCcAGuAGGCuAGAGCdTsdT
antis 1435-1454 1297 CCAACGACCGCCCGCUUCC 1298
ccAAcGAccGcccGcuuccdTsdT sense 1435-1454 1299 GGAAGCGGGCGGUCGUUGG
1300 GGAAGCGGGCGGUCGUUGGdTsdT antis 2246-2265 1301
GGCAUGAAACCCUUAAAAA 1302 GGcAuGAAAcccuuAAAAAdTsdT sense 2246-2265
1303 UUUUUAAGGGUUUCAUGCC 1304 UUUUuAAGGGUUUcAUGCCdTsdT antis 14-33
1305 AGCCGACGGCAGAGGGACU 1306 AGccGAcGGcAGAGGGAcudTsdT sense 14-33
1307 AGUCCCUCUGCCGUCGGCU 1308 AGUCCCUCUGCCGUCGGCUdTsdT antis 17-36
1309 CGACGGCAGAGGGACUUCA 1310 cGAcGGcAGAGGGAcuucAdTsdT sense 17-36
1311 UGAAGUCCCUCUGCCGUCG 1312 UGAAGUCCCUCUGCCGUCGdTsdT antis 18-37
1313 GACGGCAGAGGGACUUCAU 1314 GAcGGcAGAGGGAcuucAudTsdT sense 18-37
1315 AUGAAGUCCCUCUGCCGUC 1316 AUGAAGUCCCUCUGCCGUCdTsdT antis 78-97
1317 GCCCGAACGGCGCGGCCUG 1318 GcccGAAcGGcGcGGccuGdTsdT sense 78-97
1319 CAGGCCGCGCCGUUCGGGC 1320 cAGGCCGCGCCGUUCGGGCdTsdT antis 81-100
1321 CGAACGGCGCGGCCUGGAA 1322 cGAAcGGcGcGGccuGGAAdTsdT sense 81-100
1323 UUCCAGGCCGCGCCGUUCG 1324 UUCcAGGCCGCGCCGUUCGdTsdT antis 83-102
1325 AACGGCGCGGCCUGGAAGA 1326 AAcGGcGcGGccuGGAAGAdTsdT sense 83-102
1327 UCUUCCAGGCCGCGCCGUU 1328 UCUUCcAGGCCGCGCCGUUdTsdT antis 87-106
1329 GCGCGGCCUGGAAGAGGCC 1330 GcGcGGccuGGAAGAGGccdTsdT sense 87-106
1331 GGCCUCUUCCAGGCCGCGC 1332 GGCCUCUUCcAGGCCGCGCdTsdT antis
181-200 1333 CGCUCGGCGCCAUGAGCGG 1334 cGcucGGcGccAuGAGcGGdTsdT
sense 181-200 1335 CCGCUCAUGGCGCCGAGCG 1336
CCGCUcAUGGCGCCGAGCGdTsdT antis 183-202 1337 CUCGGCGCCAUGAGCGGCG
1338 cucGGcGccAuGAGcGGcGdTsdT sense 183-202 1339
CGCCGCUCAUGGCGCCGAG 1340 CGCCGCUcAUGGCGCCGAGdTsdT antis 189-208
1341 GCCAUGAGCGGCGGCGGGC 1342 GccAuGAGcGGcGGcGGGcdTsdT sense
189-208 1343 GCCCGCCGCCGCUCAUGGC 1344 GCCCGCCGCCGCUcAUGGCdTsdT
antis 191-210 1345 CAUGAGCGGCGGCGGGCCU 1346
cAuGAGcGGcGGcGGGccudTsdT sense 191-210 1347 AGGCCCGCCGCCGCUCAUG
1348 AGGCCCGCCGCCGCUcAUGdTsdT antis 254-273 1349
GUUCGCGGAGCCAGGAGGC 1350 GuucGcGGAGccAGGAGGcdTsdT sense 254-273
1351 GCCUCCUGGCUCCGCGAAC 1352 GCCUCCUGGCUCCGCGAACdTsdT antis
255-274 1353 UUCGCGGAGCCAGGAGGCG 1354 uucGcGGAGccAGGAGGcGdTsdT
sense 255-274 1355 CGCCUCCUGGCUCCGCGAA 1356
CGCCUCCUGGCUCCGCGAAdTsdT antis 431-450 1357 CGGCGCGGGCACUAGCUUC
1358 cGGcGcGGGcAcuAGcuucdTsdT sense 431-450 1359
GAAGCUAGUGCCCGCGCCG 1360 GAAGCuAGUGCCCGCGCCGdTsdT antis 433-452
1361 GCGCGGGCACUAGCUUCCC 1362 GcGcGGGcAcuAGcuucccdTsdT sense
433-452 1363 GGGAAGCUAGUGCCCGCGC 1364 GGGAAGCuAGUGCCCGCGCdTsdT
antis 441-460 1365 ACUAGCUUCCCGCCGCCGG 1366
AcuAGcuucccGccGccGGdTsdT sense 441-460 1367 CCGGCGGCGGGAAGCUAGU
1368 CCGGCGGCGGGAAGCuAGUdTsdT antis 442-461 1369
CUAGCUUCCCGCCGCCGGG 1370 cuAGcuucccGccGccGGGdTsdT sense 442-461
1371 CCCGGCGGCGGGAAGCUAG 1372 CCCGGCGGCGGGAAGCuAGdTsdT antis
446-465 1373 CUUCCCGCCGCCGGGAGUG 1374 cuucccGccGccGGGAGuGdTsdT
sense 446-465 1375 CACUCCCGGCGGCGGGAAG 1376
cACUCCCGGCGGCGGGAAGdTsdT antis 473-492 1377 CCGUGACAGCGGGAAGGUG
1378 ccGuGAcAGcGGGAAGGuGdTsdT sense 473-492 1379
CACCUUCCCGCUGUCACGG 1380 cACCUUCCCGCUGUcACGGdTsdT antis 532-551
1381 CCCAAGAAGUGGCUUACAC 1382 cccAAGAAGuGGcuuAcAcdTsdT sense
532-551 1383 GUGUAAGCCACUUCUUGGG 1384 GUGuAAGCcACUUCUUGGGdTsdT
antis 580-599 1385 UCGGAGUAGUAUACCAGGC 1386
ucGGAGuAGuAuAccAGGcdTsdT sense 580-599 1387 GCCUGGUAUACUACUCCGA
1388 GCCUGGuAuACuACUCCGAdTsdT antis 589-608 1389
UAUACCAGGCACGGCUGGC 1390 uAuAccAGGcAcGGcuGGcdTsdT sense 589-608
1391 GCCAGCCGUGCCUGGUAUA 1392 GCcAGCCGUGCCUGGuAuAdTsdT antis
598-617 1393 CACGGCUGGCAGAGACGAG 1394 cAcGGcuGGcAGAGAcGAGdTsdT
sense 598-617 1395 CUCGUCUCUGCCAGCCGUG 1396
CUCGUCUCUGCcAGCCGUGdTsdT antis 837-856 1397 ACCCCUAUCAUCUACAUCA
1398 AccccuAucAucuAcAucAdTsdT sense 837-856 1399
UGAUGUAGAUGAUAGGGGU 1400 UGAUGuAGAUGAuAGGGGUdTsdT antis 838-857
1401 CCCCUAUCAUCUACAUCAA 1402 ccccuAucAucuAcAucAAdTsdT sense
838-857 1403 UUGAUGUAGAUGAUAGGGG 1404 UUGAUGuAGAUGAuAGGGGdTsdT
antis 839-858 1405 CCCUAUCAUCUACAUCAAG 1406
cccuAucAucuAcAucAAGdTsdT sense 839-858 1407 CUUGAUGUAGAUGAUAGGG
1408 CUUGAUGuAGAUGAuAGGGdTsdT antis 922-941 1409
ACAUCAAGCCCCAGAAUUU 1410 AcAucAAGccccAGAAuuudTsdT sense 922-941
1411 AAAUUCUGGGGCUUGAUGU 1412 AAAUUCUGGGGCUUGAUGUdTsdT antis
923-942 1413 CAUCAAGCCCCAGAAUUUG 1414 cAucAAGccccAGAAuuuGdTsdT
sense 923-942 1415 CAAAUUCUGGGGCUUGAUG 1416
cAAAUUCUGGGGCUUGAUGdTsdT antis 1012-1031 1417 AGCCCAAUGUGUCCUACAU
1418 AGcccAAuGuGuccuAcAudTsdT sense 1012-1031 1419
AUGUAGGACACAUUGGGCU 1420 AUGuAGGAcAcAUUGGGCUdTsdT antis 1014-1033
1421 CCCAAUGUGUCCUACAUCU 1422 cccAAuGuGuccuAcAucudTsdT sense
1014-1033 1423 AGAUGUAGGACACAUUGGG 1424 AGAUGuAGGAcAcAUUGGGdTsdT
antis 1046-1065 1425 CCGUGCUCCAGAACUCAUC 1426
ccGuGcuccAGAAcucAucdTsdT sense 1046-1065 1427 GAUGAGUUCUGGAGCACGG
1428 GAUGAGUUCUGGAGcACGGdTsdT antis 1056-1075 1429
GAACUCAUCUUUGGAGCCA 1430 GAAcucAucuuuGGAGccAdTsdT sense 1056-1075
1431 UGGCUCCAAAGAUGAGUUC 1432 UGGCUCcAAAGAUGAGUUCdTsdT antis
1088-1107 1433 GUCCAUCGAUGUGUGGUCG 1434 GuccAucGAuGuGuGGucGdTsdT
sense 1088-1107 1435 CGACCACACAUCGAUGGAC 1436
CGACcAcAcAUCGAUGGACdTsdT antis 1123-1142 1437 CUGAGCUACUUCUCGGCCA
1438 cuGAGcuAcuucucGGccAdTsdT sense 1123-1142 1439
UGGCCGAGAAGUAGCUCAG 1440 UGGCCGAGAAGuAGCUcAGdTsdT antis 1232-1251
1441 GAACCCUAACUAUACGGAG 1442 GAAcccuAAcuAuAcGGAGdTsdT sense
1232-1251 1443 CUCCGUAUAGUUAGGGUUC 1444 CUCCGuAuAGUuAGGGUUCdTsdT
antis 1287-1306 1445 AAGGUGUUCAAAUCUUCAA 1446
AAGGuGuucAAAucuucAAdTsdT sense 1287-1306 1447 UUGAAGAUUUGAACACCUU
1448 UUGAAGAUUUGAAcACCUUdTsdT antis 1319-1338 1449
GGCCAUUGCACUCUGCUCU 1450 GGccAuuGcAcucuGcucudTsdT sense 1319-1338
1451 AGAGCAGAGUGCAAUGGCC 1452 AGAGcAGAGUGcAAUGGCCdTsdT antis
1349-1368 1453 GUACACGCCAUCCUCAAGG 1454 GuAcAcGccAuccucAAGGdTsdT
sense 1349-1368 1455 CCUUGAGGAUGGCGUGUAC 1456
CCUUGAGGAUGGCGUGuACdTsdT antis 1409-1428 1457 ACUGCGGAGACUCGGAGCC
1458 AcuGcGGAGAcucGGAGccdTsdT sense 1409-1428 1459
GGCUCCGAGUCUCCGCAGU 1460 GGCUCCGAGUCUCCGcAGUdTsdT antis 1410-1429
1461 CUGCGGAGACUCGGAGCCC 1462 cuGcGGAGAcucGGAGcccdTsdT sense
1410-1429 1463 GGGCUCCGAGUCUCCGCAG 1464 GGGCUCCGAGUCUCCGcAGdTsdT
antis 1448-1467 1465 GCUUCCCCCCCUGUUCAAC 1466
GcuucccccccuGuucAAcdTsdT sense 1448-1467 1467 GUUGAACAGGGGGGGAAGC
1468 GUUGAAcAGGGGGGGAAGCdTsdT antis 1449-1468 1469
CUUCCCCCCCUGUUCAACU 1470 cuucccccccuGuucAAcudTsdT sense 1449-1468
1471 AGUUGAACAGGGGGGGAAG 1472 AGUUGAAcAGGGGGGGAAGdTsdT antis
1450-1469 1473 UUCCCCCCCUGUUCAACUU 1474 uucccccccuGuucAAcuudTsdT
sense 1450-1469 1475 AAGUUGAACAGGGGGGGAA 1476
AAGUUGAAcAGGGGGGGAAdTsdT antis 1567-1586 1477 CCUACAACCCAUCCUCACA
1478 ccuAcAAcccAuccucAcAdTsdT sense 1567-1586 1479
UGUGAGGAUGGGUUGUAGG 1480 UGUGAGGAUGGGUUGuAGGdTsdT antis 1583-1602
1481 ACAAGCUUUAACUGAAGCU 1482 AcAAGcuuuAAcuGAAGcudTsdT sense
1583-1602 1483 AGCUUCAGUUAAAGCUUGU 1484 AGCUUcAGUuAAAGCUUGUdTsdT
antis 1596-1615 1485 GAAGCUCAGACUGGCCAAG 1486
GAAGcucAGAcuGGccAAGdTsdT sense 1596-1615 1487 CUUGGCCAGUCUGAGCUUC
1488 CUUGGCcAGUCUGAGCUUCdTsdT antis 1608-1627 1489
GGCCAAGAUUGGCAGCCAU 1490 GGccAAGAuuGGcAGccAudTsdT sense 1608-1627
1491 AUGGCUGCCAAUCUUGGCC 1492 AUGGCUGCcAAUCUUGGCCdTsdT antis
1638-1657 1493 ACUGCUACCCUCGCUAGCU 1494 AcuGcuAcccucGcuAGcudTsdT
sense
1638-1657 1495 AGCUAGCGAGGGUAGCAGU 1496 AGCuAGCGAGGGuAGcAGUdTsdT
antis 1854-1873 1497 UUAACUGUUUGUAGGGGAG 1498
uuAAcuGuuuGuAGGGGAGdTsdT sense 1854-1873 1499 CUCCCCUACAAACAGUUAA
1500 CUCCCCuAcAAAcAGUuAAdTsdT antis 1980-1999 1501
CUUGUAAAUAGAACCAGCC 1502 cuuGuAAAuAGAAccAGccdTsdT sense 1980-1999
1503 GGCUGGUUCUAUUUACAAG 1504 GGCUGGUUCuAUUuAcAAGdTsdT antis
2034-2053 1505 GGGUGUAAAUAGAUUGUUA 1506 GGGuGuAAAuAGAuuGuuAdTsdT
sense 2034-2053 1507 UAACAAUCUAUUUACACCC 1508
uAAcAAUCuAUUuAcACCCdTsdT antis 2037-2056 1509 UGUAAAUAGAUUGUUAUAA
1510 uGuAAAuAGAuuGuuAuAAdTsdT sense 2037-2056 1511
UUAUAACAAUCUAUUUACA 1512 UuAuAAcAAUCuAUUuAcAdTsdT antis 2087-2106
1513 AUUCAACUUGCCCCCCCCA 1514 AuucAAcuuGccccccccAdTsdT sense
2087-2106 1515 UGGGGGGGGCAAGUUGAAU 1516 UGGGGGGGGcAAGUUGAAUdTsdT
antis 2088-2107 1517 UUCAACUUGCCCCCCCCAG 1518
uucAAcuuGccccccccAGdTsdT sense 2088-2107 1519 CUGGGGGGGGCAAGUUGAA
1520 CUGGGGGGGGcAAGUUGAAdTsdT antis 2171-2190 1521
GUAGAGAGAGUCCCUGGUG 1522 GuAGAGAGAGucccuGGuGdTsdT sense 2171-2190
1523 CACCAGGGACUCUCUCUAC 1524 cACcAGGGACUCUCUCuACdTsdT antis
2212-2231 1525 UGCCUGUGUACAGACCUCU 1526 uGccuGuGuAcAGAccucudTsdT
sense 2212-2231 1527 AGAGGUCUGUACACAGGCA 1528
AGAGGUCUGuAcAcAGGcAdTsdT antis 2221-2240 1529 ACAGACCUCUGUUCAAUAA
1530 AcAGAccucuGuucAAuAAdTsdT sense 2221-2240 1531
UUAUUGAACAGAGGUCUGU 1532 UuAUUGAAcAGAGGUCUGUdTsdT antis 190-209
1533 CCAUGAGCGGCGGCGGGCC 1534 ccAuGAGcGGcGGcGGGccdTsdT sense
190-209 1535 GGCCCGCCGCCGCUCAUGG 1536 GGCCCGCCGCCGCUcAUGGdTsdT
antis 377-396 1537 CUCGAGCUCCGGGGGUGGC 1538
cucGAGcuccGGGGGuGGcdTsdT sense 377-396 1539 GCCACCCCCGGAGCUCGAG
1540 GCcACCCCCGGAGCUCGAGdTsdT antis 469-488 1541
UGGGCCGUGACAGCGGGAA 1542 uGGGccGuGAcAGcGGGAAdTsdT sense 469-488
1543 UUCCCGCUGUCACGGCCCA 1544 UUCCCGCUGUcACGGCCcAdTsdT antis
590-609 1545 AUACCAGGCACGGCUGGCA 1546 AuAccAGGcAcGGcuGGcAdTsdT
sense 590-609 1547 UGCCAGCCGUGCCUGGUAU 1548
UGCcAGCCGUGCCUGGuAUdTsdT antis 658-677 1549 UCAAGAACCGAGAACUGCA
1550 ucAAGAAccGAGAAcuGcAdTsdT sense 658-677 1551
UGCAGUUCUCGGUUCUUGA 1552 UGcAGUUCUCGGUUCUUGAdTsdT antis 998-1017
1553 GCUGGUUCGGGGGGAGCCC 1554 GcuGGuucGGGGGGAGcccdTsdT sense
998-1017 1555 GGGCUCCCCCCGAACCAGC 1556 GGGCUCCCCCCGAACcAGCdTsdT
antis 999-1018 1557 CUGGUUCGGGGGGAGCCCA 1558
cuGGuucGGGGGGAGcccAdTsdT sense 999-1018 1559 UGGGCUCCCCCCGAACCAG
1560 UGGGCUCCCCCCGAACcAGdTsdT antis 1025-1044 1561
CUACAUCUGCUCUCGGUAC 1562 cuAcAucuGcucucGGuAcdTsdT sense 1025-1044
1563 GUACCGAGAGCAGAUGUAG 1564 GuACCGAGAGcAGAUGuAGdTsdT antis
1327-1346 1565 CACUCUGCUCUAGCCUACU 1566 cAcucuGcucuAGccuAcudTsdT
sense 1327-1346 1567 AGUAGGCUAGAGCAGAGUG 1568
AGuAGGCuAGAGcAGAGUGdTsdT antis 1417-1436 1569 GACUCGGAGCCCAGCUCCC
1570 GAcucGGAGcccAGcucccdTsdT sense 1417-1436 1571
GGGAGCUGGGCUCCGAGUC 1572 GGGAGCUGGGCUCCGAGUCdTsdT antis 1594-1613
1573 CUGAAGCUCAGACUGGCCA 1574 cuGAAGcucAGAcuGGccAdTsdT sense
1594-1613 1575 UGGCCAGUCUGAGCUUCAG 1576 UGGCcAGUCUGAGCUUcAGdTsdT
antis 2213-2232 1577 GCCUGUGUACAGACCUCUG 1578
GccuGuGuAcAGAccucuGdTsdT sense 2213-2232 1579 CAGAGGUCUGUACACAGGC
1580 cAGAGGUCUGuAcAcAGGCdTsdT antis 1451-1470 1581
UCCCCCCCUGUUCAACUUC 1582 ucccccccuGuucAAcuucdTsdT sense 1451-1470
1583 GAAGUUGAACAGGGGGGGA 1584 GAAGUUGAAcAGGGGGGGAdTsdT antis
1563-1582 1585 ACUUCCUACAACCCAUCCU 1586 AcuuccuAcAAcccAuccudTsdT
sense 1563-1582 1587 AGGAUGGGUUGUAGGAAGU 1588
AGGAUGGGUUGuAGGAAGUdTsdT antis 1607-1626 1589 UGGCCAAGAUUGGCAGCCA
1590 uGGccAAGAuuGGcAGccAdTsdT sense 1607-1626 1591
UGGCUGCCAAUCUUGGCCA 1592 UGGCUGCcAAUCUUGGCcAdTsdT antis 1939-1958
1593 CCCAGGCUACCACUCCUUC 1594 cccAGGcuAccAcuccuucdTsdT sense
1939-1958 1595 GAAGGAGUGGUAGCCUGGG 1596 GAAGGAGUGGuAGCCUGGGdTsdT
antis 74-93 1597 CGGAGCCCGAACGGCGCGG 1598 cGGAGcccGAAcGGcGcGGdTsdT
sense 74-93 1599 CCGCGCCGUUCGGGCUCCG 1600 CCGCGCCGUUCGGGCUCCGdTsdT
antis 75-94 1601 GGAGCCCGAACGGCGCGGC 1602 GGAGcccGAAcGGcGcGGcdTsdT
sense 75-94 1603 GCCGCGCCGUUCGGGCUCC 1604 GCCGCGCCGUUCGGGCUCCdTsdT
antis 85-104 1605 CGGCGCGGCCUGGAAGAGG 1606 cGGcGcGGccuGGAAGAGGdTsdT
sense 85-104 1607 CCUCUUCCAGGCCGCGCCG 1608 CCUCUUCcAGGCCGCGCCGdTsdT
antis 86-105 1609 GGCGCGGCCUGGAAGAGGC 1610 GGcGcGGccuGGAAGAGGcdTsdT
sense 86-105 1611 GCCUCUUCCAGGCCGCGCC 1612 GCCUCUUCcAGGCCGCGCCdTsdT
antis 203-222 1613 CGGGCCUUCGGGAGGCGGC 1614
cGGGccuucGGGAGGcGGcdTsdT sense 203-222 1615 GCCGCCUCCCGAAGGCCCG
1616 GCCGCCUCCCGAAGGCCCGdTsdT antis 206-225 1617
GCCUUCGGGAGGCGGCCCU 1618 GccuucGGGAGGcGGcccudTsdT sense 206-225
1619 AGGGCCGCCUCCCGAAGGC 1620 AGGGCCGCCUCCCGAAGGCdTsdT antis
208-227 1621 CUUCGGGAGGCGGCCCUGG 1622 cuucGGGAGGcGGcccuGGdTsdT
sense 208-227 1623 CCAGGGCCGCCUCCCGAAG 1624
CcAGGGCCGCCUCCCGAAGdTsdT antis 245-264 1625 GACCAGCUCGUUCGCGGAG
1626 GAccAGcucGuucGcGGAGdTsdT sense 245-264 1627
CUCCGCGAACGAGCUGGUC 1628 CUCCGCGAACGAGCUGGUCdTsdT antis 448-467
1629 UCCCGCCGCCGGGAGUGAA 1630 ucccGccGccGGGAGuGAAdTsdT sense
448-467 1631 UUCACUCCCGGCGGCGGGA 1632 UUcACUCCCGGCGGCGGGAdTsdT
antis 452-471 1633 GCCGCCGGGAGUGAAGCUG 1634
GccGccGGGAGuGAAGcuGdTsdT sense 452-471 1635 CAGCUUCACUCCCGGCGGC
1636 cAGCUUcACUCCCGGCGGCdTsdT antis 453-472 1637
CCGCCGGGAGUGAAGCUGG 1638 ccGccGGGAGuGAAGcuGGdTsdT sense 453-472
1639 CCAGCUUCACUCCCGGCGG 1640 CcAGCUUcACUCCCGGCGGdTsdT antis
470-489 1641 GGGCCGUGACAGCGGGAAG 1642 GGGccGuGAcAGcGGGAAGdTsdT
sense 470-489 1643 CUUCCCGCUGUCACGGCCC 1644
CUUCCCGCUGUcACGGCCCdTsdT antis 588-607 1645 GUAUACCAGGCACGGCUGG
1646 GuAuAccAGGcAcGGcuGGdTsdT sense 588-607 1647
CCAGCCGUGCCUGGUAUAC 1648 CcAGCCGUGCCUGGuAuACdTsdT antis 609-628
1649 GAGACGAGGGAACUGGUGG 1650 GAGAcGAGGGAAcuGGuGGdTsdT sense
609-628 1651 CCACCAGUUCCCUCGUCUC 1652 CcACcAGUUCCCUCGUCUCdTsdT
antis 611-630 1653 GACGAGGGAACUGGUGGCC 1654
GAcGAGGGAAcuGGuGGccdTsdT sense 611-630 1655 GGCCACCAGUUCCCUCGUC
1656 GGCcACcAGUUCCCUCGUCdTsdT antis 649-668 1657
ACAAAAGGUUCAAGAACCG 1658 AcAAAAGGuucAAGAAccGdTsdT sense 649-668
1659 CGGUUCUUGAACCUUUUGU 1660 CGGUUCUUGAACCUUUUGUdTsdT antis
652-671 1661 AAAGGUUCAAGAACCGAGA 1662 AAAGGuucAAGAAccGAGAdTsdT
sense 652-671 1663 UCUCGGUUCUUGAACCUUU 1664
UCUCGGUUCUUGAACCUUUdTsdT antis 653-672 1665 AAGGUUCAAGAACCGAGAA
1666 AAGGuucAAGAAccGAGAAdTsdT sense 653-672 1667
UUCUCGGUUCUUGAACCUU 1668 UUCUCGGUUCUUGAACCUUdTsdT antis 742-761
1669 AGAAGAAGGACGAGCUGUA 1670 AGAAGAAGGAcGAGcuGuAdTsdT sense
742-761 1671 UACAGCUCGUCCUUCUUCU 1672 uAcAGCUCGUCCUUCUUCUdTsdT
antis 744-763 1673 AAGAAGGACGAGCUGUAUU 1674
AAGAAGGAcGAGcuGuAuudTsdT sense 744-763 1675 AAUACAGCUCGUCCUUCUU
1676 AAuAcAGCUCGUCCUUCUUdTsdT antis 790-809 1677
AGACGGUGUACCGAGUGGC 1678 AGAcGGuGuAccGAGuGGcdTsdT sense 790-809
1679 GCCACUCGGUACACCGUCU 1680 GCcACUCGGuAcACCGUCUdTsdT antis
840-859 1681 CCUAUCAUCUACAUCAAGG 1682 ccuAucAucuAcAucAAGGdTsdT
sense 840-859 1683 CCUUGAUGUAGAUGAUAGG 1684
CCUUGAUGuAGAUGAuAGGdTsdT antis 882-901 1685 AGCUUGGCCUACAUCCACU
1686 AGcuuGGccuAcAuccAcudTsdT sense 882-901 1687
AGUGGAUGUAGGCCAAGCU 1688 AGUGGAUGuAGGCcAAGCUdTsdT antis 912-931
1689 UGUCACCGUGACAUCAAGC 1690 uGucAccGuGAcAucAAGcdTsdT sense
912-931 1691 GCUUGAUGUCACGGUGACA 1692 GCUUGAUGUcACGGUGAcAdTsdT
antis 947-966 1693 GGACCCUGACACUGCUGUC 1694
GGAcccuGAcAcuGcuGucdTsdT sense 947-966 1695 GACAGCAGUGUCAGGGUCC
1696 GAcAGcAGUGUcAGGGUCCdTsdT antis 1009-1028 1697
GGGAGCCCAAUGUGUCCUA 1698 GGGAGcccAAuGuGuccuAdTsdT sense 1009-1028
1699 UAGGACACAUUGGGCUCCC 1700 uAGGAcAcAUUGGGCUCCCdTsdT antis
1017-1036 1701 AAUGUGUCCUACAUCUGCU 1702 AAuGuGuccuAcAucuGcudTsdT
sense 1017-1036 1703 AGCAGAUGUAGGACACAUU 1704
AGcAGAUGuAGGAcAcAUUdTsdT antis 1113-1132 1705 UGUGUACUUGCUGAGCUAC
1706 uGuGuAcuuGcuGAGcuAcdTsdT sense 1113-1132 1707
GUAGCUCAGCAAGUACACA 1708 GuAGCUcAGcAAGuAcAcAdTsdT antis 1121-1140
1709 UGCUGAGCUACUUCUCGGC 1710 uGcuGAGcuAcuucucGGcdTsdT sense
1121-1140 1711 GCCGAGAAGUAGCUCAGCA 1712 GCCGAGAAGuAGCUcAGcAdTsdT
antis 1268-1287 1713 CAAAGCUCACCCUUGGACA 1714
cAAAGcucAcccuuGGAcAdTsdT sense 1268-1287 1715 UGUCCAAGGGUGAGCUUUG
1716 UGUCcAAGGGUGAGCUUUGdTsdT antis 1290-1309 1717
GUGUUCAAAUCUUCAAAGA 1718 GuGuucAAAucuucAAAGAdTsdT sense 1290-1309
1719 UCUUUGAAGAUUUGAACAC 1720 UCUUUGAAGAUUUGAAcACdTsdT antis
1308-1327 1721 ACACCACCUGAGGCCAUUG 1722 AcAccAccuGAGGccAuuGdTsdT
sense 1308-1327 1723 CAAUGGCCUCAGGUGGUGU 1724
cAAUGGCCUcAGGUGGUGUdTsdT antis 1312-1331 1725 CACCUGAGGCCAUUGCACU
1726 cAccuGAGGccAuuGcAcudTsdT sense 1312-1331 1727
AGUGCAAUGGCCUCAGGUG 1728 AGUGcAAUGGCCUcAGGUGdTsdT antis 1326-1345
1729 GCACUCUGCUCUAGCCUAC 1730 GcAcucuGcucuAGccuAcdTsdT sense
1326-1345 1731 GUAGGCUAGAGCAGAGUGC 1732 GuAGGCuAGAGcAGAGUGCdTsdT
antis 1332-1351 1733 UGCUCUAGCCUACUGGAGU 1734
uGcucuAGccuAcuGGAGudTsdT sense 1332-1351 1735 ACUCCAGUAGGCUAGAGCA
1736 ACUCcAGuAGGCuAGAGcAdTsdT antis 1406-1425 1737
UGAACUGCGGAGACUCGGA 1738 uGAAcuGcGGAGAcucGGAdTsdT sense 1406-1425
1739 UCCGAGUCUCCGCAGUUCA 1740 UCCGAGUCUCCGcAGUUcAdTsdT antis
1407-1426 1741 GAACUGCGGAGACUCGGAG 1742 GAAcuGcGGAGAcucGGAGdTsdT
sense 1407-1426 1743 CUCCGAGUCUCCGCAGUUC 1744
CUCCGAGUCUCCGcAGUUCdTsdT antis
1415-1434 1745 GAGACUCGGAGCCCAGCUC 1746 GAGAcucGGAGcccAGcucdTsdT
sense 1415-1434 1747 GAGCUGGGCUCCGAGUCUC 1748
GAGCUGGGCUCCGAGUCUCdTsdT antis 1464-1483 1749 AACUUCAGUCCUGGUGAAC
1750 AAcuucAGuccuGGuGAAcdTsdT sense 1464-1483 1751
GUUCACCAGGACUGAAGUU 1752 GUUcACcAGGACUGAAGUUdTsdT antis 1465-1484
1753 ACUUCAGUCCUGGUGAACU 1754 AcuucAGuccuGGuGAAcudTsdT sense
1465-1484 1755 AGUUCACCAGGACUGAAGU 1756 AGUUcACcAGGACUGAAGUdTsdT
antis 1479-1498 1757 GAACUGUCCAUCCAACCAU 1758
GAAcuGuccAuccAAccAudTsdT sense 1479-1498 1759 AUGGUUGGAUGGACAGUUC
1760 AUGGUUGGAUGGAcAGUUCdTsdT antis 1566-1585 1761
UCCUACAACCCAUCCUCAC 1762 uccuAcAAcccAuccucAcdTsdT sense 1566-1585
1763 GUGAGGAUGGGUUGUAGGA 1764 GUGAGGAUGGGUUGuAGGAdTsdT antis
1571-1590 1765 CAACCCAUCCUCACAAGCU 1766 cAAcccAuccucAcAAGcudTsdT
sense 1571-1590 1767 AGCUUGUGAGGAUGGGUUG 1768
AGCUUGUGAGGAUGGGUUGdTsdT antis 1584-1603 1769 CAAGCUUUAACUGAAGCUC
1770 cAAGcuuuAAcuGAAGcucdTsdT sense 1584-1603 1771
GAGCUUCAGUUAAAGCUUG 1772 GAGCUUcAGUuAAAGCUUGdTsdT antis 1802-1821
1773 CUAGGCCUCCCUCAGCAGC 1774 cuAGGccucccucAGcAGcdTsdT sense
1802-1821 1775 GCUGCUGAGGGAGGCCUAG 1776 GCUGCUGAGGGAGGCCuAGdTsdT
antis 1938-1957 1777 CCCCAGGCUACCACUCCUU 1778
ccccAGGcuAccAcuccuudTsdT sense 1938-1957 1779 AAGGAGUGGUAGCCUGGGG
1780 AAGGAGUGGuAGCCUGGGGdTsdT antis 1986-2005 1781
AAUAGAACCAGCCCAGCCC 1782 AAuAGAAccAGcccAGcccdTsdT sense 1986-2005
1783 GGGCUGGGCUGGUUCUAUU 1784 GGGCUGGGCUGGUUCuAUUdTsdT antis
1987-2006 1785 AUAGAACCAGCCCAGCCCA 1786 AuAGAAccAGcccAGcccAdTsdT
sense 1987-2006 1787 UGGGCUGGGCUGGUUCUAU 1788
UGGGCUGGGCUGGUUCuAUdTsdT antis 2032-2051 1789 CUGGGUGUAAAUAGAUUGU
1790 cuGGGuGuAAAuAGAuuGudTsdT sense 2032-2051 1791
ACAAUCUAUUUACACCCAG 1792 AcAAUCuAUUuAcACCcAGdTsdT antis 2085-2104
1793 CCAUUCAACUUGCCCCCCC 1794 ccAuucAAcuuGcccccccdTsdT sense
2085-2104 1795 GGGGGGGCAAGUUGAAUGG 1796 GGGGGGGcAAGUUGAAUGGdTsdT
antis 2090-2109 1797 CAACUUGCCCCCCCCAGCU 1798
cAAcuuGccccccccAGcudTsdT sense 2090-2109 1799 AGCUGGGGGGGGCAAGUUG
1800 AGCUGGGGGGGGcAAGUUGdTsdT antis 2094-2113 1801
UUGCCCCCCCCAGCUGUAC 1802 uuGccccccccAGcuGuAcdTsdT sense 2094-2113
1803 GUACAGCUGGGGGGGGCAA 1804 GuAcAGCUGGGGGGGGcAAdTsdT antis
2101-2120 1805 CCCCAGCUGUACCCCUUCU 1806 ccccAGcuGuAccccuucudTsdT
sense 2101-2120 1807 AGAAGGGGUACAGCUGGGG 1808
AGAAGGGGuAcAGCUGGGGdTsdT antis 2104-2123 1809 CAGCUGUACCCCUUCUUGU
1810 cAGcuGuAccccuucuuGudTsdT sense 2104-2123 1811
ACAAGAAGGGGUACAGCUG 1812 AcAAGAAGGGGuAcAGCUGdTsdT antis 2105-2124
1813 AGCUGUACCCCUUCUUGUC 1814 AGcuGuAccccuucuuGucdTsdT sense
2105-2124 1815 GACAAGAAGGGGUACAGCU 1816 GAcAAGAAGGGGuAcAGCUdTsdT
antis 2155-2174 1817 UCCUGGAAGGAGGGGAGUA 1818
uccuGGAAGGAGGGGAGuAdTsdT sense 2155-2174 1819 UACUCCCCUCCUUCCAGGA
1820 uACUCCCCUCCUUCcAGGAdTsdT antis 2167-2186 1821
GGGAGUAGAGAGAGUCCCU 1822 GGGAGuAGAGAGAGucccudTsdT sense 2167-2186
1823 AGGGACUCUCUCUACUCCC 1824 AGGGACUCUCUCuACUCCCdTsdT antis
2174-2193 1825 GAGAGAGUCCCUGGUGUCU 1826 GAGAGAGucccuGGuGucudTsdT
sense 2174-2193 1827 AGACACCAGGGACUCUCUC 1828
AGAcACcAGGGACUCUCUCdTsdT antis 2216-2235 1829 UGUGUACAGACCUCUGUUC
1830 uGuGuAcAGAccucuGuucdTsdT sense 2216-2235 1831
GAACAGAGGUCUGUACACA 1832 GAAcAGAGGUCUGuAcAcAdTsdT antis 2217-2236
1833 GUGUACAGACCUCUGUUCA 1834 GuGuAcAGAccucuGuucAdTsdT sense
2217-2236 1835 UGAACAGAGGUCUGUACAC 1836 UGAAcAGAGGUCUGuAcACdTsdT
antis 2236-2255 1837 AUAAAUUAUUGGCAUGAAA 1838
AuAAAuuAuuGGcAuGAAAdTsdT sense 2236-2255 1839 UUUCAUGCCAAUAAUUUAU
1840 UUUcAUGCcAAuAAUUuAUdTsdT antis 2237-2256 1841
UAAAUUAUUGGCAUGAAAC 1842 uAAAuuAuuGGcAuGAAAcdTsdT sense 2237-2256
1843 GUUUCAUGCCAAUAAUUUA 1844 GUUUcAUGCcAAuAAUUuAdTsdT antis
2245-2264 1845 UGGCAUGAAACCCUUAAAA 1846 uGGcAuGAAAcccuuAAAAdTsdT
sense 2245-2264 1847 UUUUAAGGGUUUCAUGCCA 1848
UUUuAAGGGUUUcAUGCcAdTsdT antis 13-32 1849 AAGCCGACGGCAGAGGGAC 1850
AAGccGAcGGcAGAGGGAcdTsdT sense 13-32 1851 GUCCCUCUGCCGUCGGCUU 1852
GUCCCUCUGCCGUCGGCUUdTsdT antis 21-40 1853 GGCAGAGGGACUUCAUCUC 1854
GGcAGAGGGAcuucAucucdTsdT sense 21-40 1855 GAGAUGAAGUCCCUCUGCC 1856
GAGAUGAAGUCCCUCUGCCdTsdT antis 22-41 1857 GCAGAGGGACUUCAUCUCC 1858
GcAGAGGGAcuucAucuccdTsdT sense 22-41 1859 GGAGAUGAAGUCCCUCUGC 1860
GGAGAUGAAGUCCCUCUGCdTsdT antis 23-42 1861 CAGAGGGACUUCAUCUCCC 1862
cAGAGGGAcuucAucucccdTsdT sense 23-42 1863 GGGAGAUGAAGUCCCUCUG 1864
GGGAGAUGAAGUCCCUCUGdTsdT antis 25-44 1865 GAGGGACUUCAUCUCCCGG 1866
GAGGGAcuucAucucccGGdTsdT sense 25-44 1867 CCGGGAGAUGAAGUCCCUC 1868
CCGGGAGAUGAAGUCCCUCdTsdT antis 30-49 1869 ACUUCAUCUCCCGGCGUGC 1870
AcuucAucucccGGcGuGcdTsdT sense 30-49 1871 GCACGCCGGGAGAUGAAGU 1872
GcACGCCGGGAGAUGAAGUdTsdT antis 31-50 1873 CUUCAUCUCCCGGCGUGCC 1874
cuucAucucccGGcGuGccdTsdT sense 31-50 1875 GGCACGCCGGGAGAUGAAG 1876
GGcACGCCGGGAGAUGAAGdTsdT antis 32-51 1877 UUCAUCUCCCGGCGUGCCC 1878
uucAucucccGGcGuGcccdTsdT sense 32-51 1879 GGGCACGCCGGGAGAUGAA 1880
GGGcACGCCGGGAGAUGAAdTsdT antis 36-55 1881 UCUCCCGGCGUGCCCCGCG 1882
ucucccGGcGuGccccGcGdTsdT sense 36-55 1883 CGCGGGGCACGCCGGGAGA 1884
CGCGGGGcACGCCGGGAGAdTsdT antis 41-60 1885 CGGCGUGCCCCGCGGCGGG 1886
cGGcGuGccccGcGGcGGGdTsdT sense 41-60 1887 CCCGCCGCGGGGCACGCCG 1888
CCCGCCGCGGGGcACGCCGdTsdT antis 44-63 1889 CGUGCCCCGCGGCGGGCGC 1890
cGuGccccGcGGcGGGcGcdTsdT sense 44-63 1891 GCGCCCGCCGCGGGGCACG 1892
GCGCCCGCCGCGGGGcACGdTsdT antis 45-64 1893 GUGCCCCGCGGCGGGCGCU 1894
GuGccccGcGGcGGGcGcudTsdT sense 45-64 1895 AGCGCCCGCCGCGGGGCAC 1896
AGCGCCCGCCGCGGGGcACdTsdT antis 52-71 1897 GCGGCGGGCGCUGGGCCGG 1898
GcGGcGGGcGcuGGGccGGdTsdT sense 52-71 1899 CCGGCCCAGCGCCCGCCGC 1900
CCGGCCcAGCGCCCGCCGCdTsdT antis 58-77 1901 GGCGCUGGGCCGGAGCCGG 1902
GGcGcuGGGccGGAGccGGdTsdT sense 58-77 1903 CCGGCUCCGGCCCAGCGCC 1904
CCGGCUCCGGCCcAGCGCCdTsdT antis 84-103 1905 ACGGCGCGGCCUGGAAGAG 1906
AcGGcGcGGccuGGAAGAGdTsdT sense 84-103 1907 CUCUUCCAGGCCGCGCCGU 1908
CUCUUCcAGGCCGCGCCGUdTsdT antis 88-107 1909 CGCGGCCUGGAAGAGGCCG 1910
cGcGGccuGGAAGAGGccGdTsdT sense 88-107 1911 CGGCCUCUUCCAGGCCGCG 1912
CGGCCUCUUCcAGGCCGCGdTsdT antis 94-113 1913 CUGGAAGAGGCCGGAGCCC 1914
cuGGAAGAGGccGGAGcccdTsdT sense 94-113 1915 GGGCUCCGGCCUCUUCCAG 1916
GGGCUCCGGCCUCUUCcAGdTsdT antis 98-117 1917 AAGAGGCCGGAGCCCAGGG 1918
AAGAGGccGGAGcccAGGGdTsdT sense 98-117 1919 CCCUGGGCUCCGGCCUCUU 1920
CCCUGGGCUCCGGCCUCUUdTsdT antis 100-119 1921 GAGGCCGGAGCCCAGGGGA
1922 GAGGccGGAGcccAGGGGAdTsdT sense 100-119 1923
UCCCCUGGGCUCCGGCCUC 1924 UCCCCUGGGCUCCGGCCUCdTsdT antis 144-163
1925 GCAGCCCAGGCAGCCCGAG 1926 GcAGcccAGGcAGcccGAGdTsdT sense
144-163 1927 CUCGGGCUGCCUGGGCUGC 1928 CUCGGGCUGCCUGGGCUGCdTsdT
antis 145-164 1929 CAGCCCAGGCAGCCCGAGC 1930
cAGcccAGGcAGcccGAGcdTsdT sense 145-164 1931 GCUCGGGCUGCCUGGGCUG
1932 GCUCGGGCUGCCUGGGCUGdTsdT antis 148-167 1933
CCCAGGCAGCCCGAGCCCC 1934 cccAGGcAGcccGAGccccdTsdT sense 148-167
1935 GGGGCUCGGGCUGCCUGGG 1936 GGGGCUCGGGCUGCCUGGGdTsdT antis
149-168 1937 CCAGGCAGCCCGAGCCCCG 1938 ccAGGcAGcccGAGccccGdTsdT
sense 149-168 1939 CGGGGCUCGGGCUGCCUGG 1940
CGGGGCUCGGGCUGCCUGGdTsdT antis 157-176 1941 CCCGAGCCCCGCGGCCUGG
1942 cccGAGccccGcGGccuGGdTsdT sense 157-176 1943
CCAGGCCGCGGGGCUCGGG 1944 CcAGGCCGCGGGGCUCGGGdTsdT antis 168-187
1945 CGGCCUGGGCCUGCGCUCG 1946 cGGccuGGGccuGcGcucGdTsdT sense
168-187 1947 CGAGCGCAGGCCCAGGCCG 1948 CGAGCGcAGGCCcAGGCCGdTsdT
antis 169-188 1949 GGCCUGGGCCUGCGCUCGG 1950
GGccuGGGccuGcGcucGGdTsdT sense 169-188 1951 CCGAGCGCAGGCCCAGGCC
1952 CCGAGCGcAGGCCcAGGCCdTsdT antis 175-194 1953
GGCCUGCGCUCGGCGCCAU 1954 GGccuGcGcucGGcGccAudTsdT sense 175-194
1955 AUGGCGCCGAGCGCAGGCC 1956 AUGGCGCCGAGCGcAGGCCdTsdT antis
179-198 1957 UGCGCUCGGCGCCAUGAGC 1958 uGcGcucGGcGccAuGAGcdTsdT
sense 179-198 1959 GCUCAUGGCGCCGAGCGCA 1960
GCUcAUGGCGCCGAGCGcAdTsdT antis 192-211 1961 AUGAGCGGCGGCGGGCCUU
1962 AuGAGcGGcGGcGGGccuudTsdT sense 192-211 1963
AAGGCCCGCCGCCGCUCAU 1964 AAGGCCCGCCGCCGCUcAUdTsdT antis 193-212
1965 UGAGCGGCGGCGGGCCUUC 1966 uGAGcGGcGGcGGGccuucdTsdT sense
193-212 1967 GAAGGCCCGCCGCCGCUCA 1968 GAAGGCCCGCCGCCGCUcAdTsdT
antis 194-213 1969 GAGCGGCGGCGGGCCUUCG 1970
GAGcGGcGGcGGGccuucGdTsdT sense 194-213 1971 CGAAGGCCCGCCGCCGCUC
1972 CGAAGGCCCGCCGCCGCUCdTsdT antis 195-214 1973
AGCGGCGGCGGGCCUUCGG 1974 AGcGGcGGcGGGccuucGGdTsdT sense 195-214
1975 CCGAAGGCCCGCCGCCGCU 1976 CCGAAGGCCCGCCGCCGCUdTsdT antis
197-216 1977 CGGCGGCGGGCCUUCGGGA 1978 cGGcGGcGGGccuucGGGAdTsdT
sense 197-216 1979 UCCCGAAGGCCCGCCGCCG 1980
UCCCGAAGGCCCGCCGCCGdTsdT antis 200-219 1981 CGGCGGGCCUUCGGGAGGC
1982 cGGcGGGccuucGGGAGGcdTsdT sense 200-219 1983
GCCUCCCGAAGGCCCGCCG 1984 GCCUCCCGAAGGCCCGCCGdTsdT antis 246-265
1985 ACCAGCUCGUUCGCGGAGC 1986 AccAGcucGuucGcGGAGcdTsdT sense
246-265 1987 GCUCCGCGAACGAGCUGGU 1988 GCUCCGCGAACGAGCUGGUdTsdT
antis 253-272 1989 CGUUCGCGGAGCCAGGAGG 1990
cGuucGcGGAGccAGGAGGdTsdT sense 253-272 1991 CCUCCUGGCUCCGCGAACG
1992 CCUCCUGGCUCCGCGAACGdTsdT antis 257-276 1993
CGCGGAGCCAGGAGGCGGA 1994 cGcGGAGccAGGAGGcGGAdTsdT sense 257-276
1995 UCCGCCUCCUGGCUCCGCG 1996 UCCGCCUCCUGGCUCCGCGdTsdT antis
258-277 1997 GCGGAGCCAGGAGGCGGAG 1998 GcGGAGccAGGAGGcGGAGdTsdT
sense 258-277 1999 CUCCGCCUCCUGGCUCCGC 2000
CUCCGCCUCCUGGCUCCGCdTsdT antis 297-316 2001 CCCGGGGGCUCGGCCUCUG
2002 cccGGGGGcucGGccucuGdTsdT sense 297-316 2003
CAGAGGCCGAGCCCCCGGG 2004 cAGAGGCCGAGCCCCCGGGdTsdT antis 298-317
2005 CCGGGGGCUCGGCCUCUGG 2006 ccGGGGGcucGGccucuGGdTsdT sense
298-317 2007 CCAGAGGCCGAGCCCCCGG 2008 CcAGAGGCCGAGCCCCCGGdTsdT
antis 321-340 2009 GGAGGCACUGGCGGCGGGA 2010
GGAGGcAcuGGcGGcGGGAdTsdT sense 321-340 2011 UCCCGCCGCCAGUGCCUCC
2012 UCCCGCCGCcAGUGCCUCCdTsdT antis 323-342 2013
AGGCACUGGCGGCGGGAAA 2014 AGGcAcuGGcGGcGGGAAAdTsdT sense 323-342
2015 UUUCCCGCCGCCAGUGCCU 2016 UUUCCCGCCGCcAGUGCCUdTsdT antis
325-344 2017 GCACUGGCGGCGGGAAAGC 2018 GcAcuGGcGGcGGGAAAGcdTsdT
sense 325-344 2019 GCUUUCCCGCCGCCAGUGC 2020
GCUUUCCCGCCGCcAGUGCdTsdT antis 326-345 2021 CACUGGCGGCGGGAAAGCG
2022 cAcuGGcGGcGGGAAAGcGdTsdT sense 326-345 2023
CGCUUUCCCGCCGCCAGUG 2024 CGCUUUCCCGCCGCcAGUGdTsdT antis 338-357
2025 GAAAGCGUCAGUCGGGGCU 2026 GAAAGcGucAGucGGGGcudTsdT sense
338-357 2027 AGCCCCGACUGACGCUUUC 2028 AGCCCCGACUGACGCUUUCdTsdT
antis 370-389 2029 UGGGAGCCUCGAGCUCCGG 2030
uGGGAGccucGAGcuccGGdTsdT sense 370-389 2031 CCGGAGCUCGAGGCUCCCA
2032 CCGGAGCUCGAGGCUCCcAdTsdT antis 371-390 2033
GGGAGCCUCGAGCUCCGGG 2034 GGGAGccucGAGcuccGGGdTsdT sense 371-390
2035 CCCGGAGCUCGAGGCUCCC 2036 CCCGGAGCUCGAGGCUCCCdTsdT antis
372-391 2037 GGAGCCUCGAGCUCCGGGG 2038 GGAGccucGAGcuccGGGGdTsdT
sense 372-391 2039 CCCCGGAGCUCGAGGCUCC 2040
CCCCGGAGCUCGAGGCUCCdTsdT antis 373-392 2041 GAGCCUCGAGCUCCGGGGG
2042 GAGccucGAGcuccGGGGGdTsdT sense 373-392 2043
CCCCCGGAGCUCGAGGCUC 2044 CCCCCGGAGCUCGAGGCUCdTsdT antis 375-394
2045 GCCUCGAGCUCCGGGGGUG 2046 GccucGAGcuccGGGGGuGdTsdT sense
375-394 2047 CACCCCCGGAGCUCGAGGC 2048 cACCCCCGGAGCUCGAGGCdTsdT
antis 380-399 2049 GAGCUCCGGGGGUGGCCCC 2050
GAGcuccGGGGGuGGccccdTsdT sense 380-399 2051 GGGGCCACCCCCGGAGCUC
2052 GGGGCcACCCCCGGAGCUCdTsdT antis 385-404 2053
CCGGGGGUGGCCCCAGCGG 2054 ccGGGGGuGGccccAGcGGdTsdT sense 385-404
2055 CCGCUGGGGCCACCCCCGG 2056 CCGCUGGGGCcACCCCCGGdTsdT antis
389-408 2057 GGGUGGCCCCAGCGGCAGC 2058 GGGuGGccccAGcGGcAGcdTsdT
sense 389-408 2059 GCUGCCGCUGGGGCCACCC 2060
GCUGCCGCUGGGGCcACCCdTsdT antis 439-458 2061 GCACUAGCUUCCCGCCGCC
2062 GcAcuAGcuucccGccGccdTsdT sense 439-458 2063
GGCGGCGGGAAGCUAGUGC 2064 GGCGGCGGGAAGCuAGUGCdTsdT antis 440-459
2065 CACUAGCUUCCCGCCGCCG 2066 cAcuAGcuucccGccGccGdTsdT sense
440-459 2067 CGGCGGCGGGAAGCUAGUG 2068 CGGCGGCGGGAAGCuAGUGdTsdT
antis 445-464 2069 GCUUCCCGCCGCCGGGAGU 2070
GcuucccGccGccGGGAGudTsdT sense 445-464 2071 ACUCCCGGCGGCGGGAAGC
2072 ACUCCCGGCGGCGGGAAGCdTsdT antis 447-466 2073
UUCCCGCCGCCGGGAGUGA 2074 uucccGccGccGGGAGuGAdTsdT sense 447-466
2075 UCACUCCCGGCGGCGGGAA 2076 UcACUCCCGGCGGCGGGAAdTsdT antis
463-482 2077 UGAAGCUGGGCCGUGACAG 2078 uGAAGcuGGGccGuGAcAGdTsdT
sense 463-482 2079 CUGUCACGGCCCAGCUUCA 2080
CUGUcACGGCCcAGCUUcAdTsdT antis 471-490 2081 GGCCGUGACAGCGGGAAGG
2082 GGccGuGAcAGcGGGAAGGdTsdT sense 471-490 2083
CCUUCCCGCUGUCACGGCC 2084 CCUUCCCGCUGUcACGGCCdTsdT antis 474-493
2085 CGUGACAGCGGGAAGGUGA 2086 cGuGAcAGcGGGAAGGuGAdTsdT sense
474-493 2087 UCACCUUCCCGCUGUCACG 2088 UcACCUUCCCGCUGUcACGdTsdT
antis 492-511 2089 ACCACAGUGGUAGCCACUG 2090
AccAcAGuGGuAGccAcuGdTsdT sense 492-511 2091 CAGUGGCUACCACUGUGGU
2092 cAGUGGCuACcACUGUGGUdTsdT antis 495-514 2093
ACAGUGGUAGCCACUGUAG 2094 AcAGuGGuAGccAcuGuAGdTsdT sense 495-514
2095 CUACAGUGGCUACCACUGU 2096 CuAcAGUGGCuACcACUGUdTsdT antis
496-515 2097 CAGUGGUAGCCACUGUAGG 2098 cAGuGGuAGccAcuGuAGGdTsdT
sense 496-515 2099 CCUACAGUGGCUACCACUG 2100
CCuAcAGUGGCuACcACUGdTsdT antis 506-525 2101 CACUGUAGGCCAAGGCCCA
2102 cAcuGuAGGccAAGGcccAdTsdT sense 506-525 2103
UGGGCCUUGGCCUACAGUG 2104 UGGGCCUUGGCCuAcAGUGdTsdT antis 507-526
2105 ACUGUAGGCCAAGGCCCAG 2106 AcuGuAGGccAAGGcccAGdTsdT sense
507-526 2107 CUGGGCCUUGGCCUACAGU 2108 CUGGGCCUUGGCCuAcAGUdTsdT
antis 509-528 2109 UGUAGGCCAAGGCCCAGAG 2110
uGuAGGccAAGGcccAGAGdTsdT sense 509-528 2111 CUCUGGGCCUUGGCCUACA
2112 CUCUGGGCCUUGGCCuAcAdTsdT antis 510-529 2113
GUAGGCCAAGGCCCAGAGC 2114 GuAGGccAAGGcccAGAGcdTsdT sense 510-529
2115 GCUCUGGGCCUUGGCCUAC 2116 GCUCUGGGCCUUGGCCuACdTsdT antis
582-601 2117 GGAGUAGUAUACCAGGCAC 2118 GGAGuAGuAuAccAGGcAcdTsdT
sense 582-601 2119 GUGCCUGGUAUACUACUCC 2120
GUGCCUGGuAuACuACUCCdTsdT antis 585-604 2121 GUAGUAUACCAGGCACGGC
2122 GuAGuAuAccAGGcAcGGcdTsdT sense 585-604 2123
GCCGUGCCUGGUAUACUAC 2124 GCCGUGCCUGGuAuACuACdTsdT antis 595-614
2125 AGGCACGGCUGGCAGAGAC 2126 AGGcAcGGcuGGcAGAGAcdTsdT sense
595-614 2127 GUCUCUGCCAGCCGUGCCU 2128 GUCUCUGCcAGCCGUGCCUdTsdT
antis 596-615 2129 GGCACGGCUGGCAGAGACG 2130
GGcAcGGcuGGcAGAGAcGdTsdT sense 596-615 2131 CGUCUCUGCCAGCCGUGCC
2132 CGUCUCUGCcAGCCGUGCCdTsdT antis 597-616 2133
GCACGGCUGGCAGAGACGA 2134 GcAcGGcuGGcAGAGAcGAdTsdT sense 597-616
2135 UCGUCUCUGCCAGCCGUGC 2136 UCGUCUCUGCcAGCCGUGCdTsdT antis
610-629 2137 AGACGAGGGAACUGGUGGC 2138 AGAcGAGGGAAcuGGuGGcdTsdT
sense 610-629 2139 GCCACCAGUUCCCUCGUCU 2140
GCcACcAGUUCCCUCGUCUdTsdT antis 612-631 2141 ACGAGGGAACUGGUGGCCA
2142 AcGAGGGAAcuGGuGGccAdTsdT sense 612-631 2143
UGGCCACCAGUUCCCUCGU 2144 UGGCcACcAGUUCCCUCGUdTsdT antis 614-633
2145 GAGGGAACUGGUGGCCAUC 2146 GAGGGAAcuGGuGGccAucdTsdT sense
614-633 2147 GAUGGCCACCAGUUCCCUC 2148 GAUGGCcACcAGUUCCCUCdTsdT
antis 646-665 2149 AGGACAAAAGGUUCAAGAA 2150
AGGAcAAAAGGuucAAGAAdTsdT sense 646-665 2151 UUCUUGAACCUUUUGUCCU
2152 UUCUUGAACCUUUUGUCCUdTsdT antis 661-680 2153
AGAACCGAGAACUGCAGAU 2154 AGAAccGAGAAcuGcAGAudTsdT sense 661-680
2155 AUCUGCAGUUCUCGGUUCU 2156 AUCUGcAGUUCUCGGUUCUdTsdT antis
668-687 2157 AGAACUGCAGAUUAUGCGU 2158 AGAAcuGcAGAuuAuGcGudTsdT
sense 668-687 2159 ACGCAUAAUCUGCAGUUCU 2160
ACGcAuAAUCUGcAGUUCUdTsdT antis 669-688 2161 GAACUGCAGAUUAUGCGUA
2162 GAAcuGcAGAuuAuGcGuAdTsdT sense 669-688 2163
UACGCAUAAUCUGCAGUUC 2164 uACGcAuAAUCUGcAGUUCdTsdT antis 703-722
2165 AUAUUGUGAGGCUGCGGUA 2166 AuAuuGuGAGGcuGcGGuAdTsdT sense
703-722 2167 UACCGCAGCCUCACAAUAU 2168 uACCGcAGCCUcAcAAuAUdTsdT
antis 704-723 2169 UAUUGUGAGGCUGCGGUAC 2170
uAuuGuGAGGcuGcGGuAcdTsdT sense 704-723 2171 GUACCGCAGCCUCACAAUA
2172 GuACCGcAGCCUcAcAAuAdTsdT antis 705-724 2173
AUUGUGAGGCUGCGGUACU 2174 AuuGuGAGGcuGcGGuAcudTsdT sense 705-724
2175 AGUACCGCAGCCUCACAAU 2176 AGuACCGcAGCCUcAcAAUdTsdT antis
738-757 2177 GGGGAGAAGAAGGACGAGC 2178 GGGGAGAAGAAGGAcGAGcdTsdT
sense 738-757 2179 GCUCGUCCUUCUUCUCCCC 2180
GCUCGUCCUUCUUCUCCCCdTsdT antis 824-843 2181 GGCCAAGCUGAUCACCCCU
2182 GGccAAGcuGAucAccccudTsdT sense 824-843 2183
AGGGGUGAUCAGCUUGGCC 2184 AGGGGUGAUcAGCUUGGCCdTsdT antis 827-846
2185 CAAGCUGAUCACCCCUAUC 2186 cAAGcuGAucAccccuAucdTsdT sense
827-846 2187 GAUAGGGGUGAUCAGCUUG 2188 GAuAGGGGUGAUcAGCUUGdTsdT
antis 879-898 2189 CGGAGCUUGGCCUACAUCC 2190
cGGAGcuuGGccuAcAuccdTsdT sense 879-898 2191 GGAUGUAGGCCAAGCUCCG
2192 GGAUGuAGGCcAAGCUCCGdTsdT antis 880-899 2193
GGAGCUUGGCCUACAUCCA 2194 GGAGcuuGGccuAcAuccAdTsdT sense 880-899
2195 UGGAUGUAGGCCAAGCUCC 2196 UGGAUGuAGGCcAAGCUCCdTsdT antis
881-900 2197 GAGCUUGGCCUACAUCCAC 2198 GAGcuuGGccuAcAuccAcdTsdT
sense 881-900 2199 GUGGAUGUAGGCCAAGCUC 2200
GUGGAUGuAGGCcAAGCUCdTsdT antis 884-903 2201 CUUGGCCUACAUCCACUCC
2202 cuuGGccuAcAuccAcuccdTsdT sense 884-903 2203
GGAGUGGAUGUAGGCCAAG 2204 GGAGUGGAUGuAGGCcAAGdTsdT antis 886-905
2205 UGGCCUACAUCCACUCCCA 2206 uGGccuAcAuccAcucccAdTsdT sense
886-905 2207 UGGGAGUGGAUGUAGGCCA 2208 UGGGAGUGGAUGuAGGCcAdTsdT
antis 896-915 2209 CCACUCCCAAGGUGUGUGU 2210
ccAcucccAAGGuGuGuGudTsdT sense 896-915 2211 ACACACACCUUGGGAGUGG
2212 AcAcAcACCUUGGGAGUGGdTsdT antis 916-935 2213
ACCGUGACAUCAAGCCCCA 2214 AccGuGAcAucAAGccccAdTsdT sense 916-935
2215 UGGGGCUUGAUGUCACGGU 2216 UGGGGCUUGAUGUcACGGUdTsdT antis
917-936 2217 CCGUGACAUCAAGCCCCAG 2218 ccGuGAcAucAAGccccAGdTsdT
sense 917-936 2219 CUGGGGCUUGAUGUCACGG 2220
CUGGGGCUUGAUGUcACGGdTsdT antis 931-950 2221 CCCAGAAUUUGCUUGUGGA
2222 cccAGAAuuuGcuuGuGGAdTsdT sense 931-950 2223
UCCACAAGCAAAUUCUGGG 2224 UCcAcAAGcAAAUUCUGGGdTsdT antis 933-952
2225 CAGAAUUUGCUUGUGGACC 2226 cAGAAuuuGcuuGuGGAccdTsdT sense
933-952 2227 GGUCCACAAGCAAAUUCUG 2228 GGUCcAcAAGcAAAUUCUGdTsdT
antis 991-1010 2229 CAAAGCAGCUGGUUCGGGG 2230
cAAAGcAGcuGGuucGGGGdTsdT sense 991-1010 2231 CCCCGAACCAGCUGCUUUG
2232 CCCCGAACcAGCUGCUUUGdTsdT antis 993-1012 2233
AAGCAGCUGGUUCGGGGGG 2234 AAGcAGcuGGuucGGGGGGdTsdT sense 993-1012
2235 CCCCCCGAACCAGCUGCUU 2236 CCCCCCGAACcAGCUGCUUdTsdT antis
1000-1019 2237 UGGUUCGGGGGGAGCCCAA 2238 uGGuucGGGGGGAGcccAAdTsdT
sense 1000-1019 2239 UUGGGCUCCCCCCGAACCA 2240
UUGGGCUCCCCCCGAACcAdTsdT antis 1003-1022 2241 UUCGGGGGGAGCCCAAUGU
2242 uucGGGGGGAGcccAAuGudTsdT sense 1003-1022 2243
ACAUUGGGCUCCCCCCGAA 2244 AcAUUGGGCUCCCCCCGAAdTsdT antis 1004-1023
2245 UCGGGGGGAGCCCAAUGUG 2246 ucGGGGGGAGcccAAuGuGdTsdT sense
1004-1023 2247 CACAUUGGGCUCCCCCCGA 2248 cAcAUUGGGCUCCCCCCGAdTsdT
antis 1006-1025 2249 GGGGGGAGCCCAAUGUGUC 2250
GGGGGGAGcccAAuGuGucdTsdT sense 1006-1025 2251 GACACAUUGGGCUCCCCCC
2252 GAcAcAUUGGGCUCCCCCCdTsdT antis 1015-1034 2253
CCAAUGUGUCCUACAUCUG 2254 ccAAuGuGuccuAcAucuGdTsdT sense 1015-1034
2255 CAGAUGUAGGACACAUUGG 2256 cAGAUGuAGGAcAcAUUGGdTsdT antis
1016-1035 2257 CAAUGUGUCCUACAUCUGC 2258 cAAuGuGuccuAcAucuGcdTsdT
sense 1016-1035 2259 GCAGAUGUAGGACACAUUG 2260
GcAGAUGuAGGAcAcAUUGdTsdT antis 1031-1050 2261 CUGCUCUCGGUACUACCGU
2262 cuGcucucGGuAcuAccGudTsdT sense 1031-1050 2263
ACGGUAGUACCGAGAGCAG 2264 ACGGuAGuACCGAGAGcAGdTsdT antis 1045-1064
2265 ACCGUGCUCCAGAACUCAU 2266 AccGuGcuccAGAAcucAudTsdT sense
1045-1064 2267 AUGAGUUCUGGAGCACGGU 2268 AUGAGUUCUGGAGcACGGUdTsdT
antis 1047-1066 2269 CGUGCUCCAGAACUCAUCU 2270
cGuGcuccAGAAcucAucudTsdT sense 1047-1066 2271 AGAUGAGUUCUGGAGCACG
2272 AGAUGAGUUCUGGAGcACGdTsdT antis 1051-1070 2273
CUCCAGAACUCAUCUUUGG 2274 cuccAGAAcucAucuuuGGdTsdT sense 1051-1070
2275 CCAAAGAUGAGUUCUGGAG 2276 CcAAAGAUGAGUUCUGGAGdTsdT antis
1055-1074 2277 AGAACUCAUCUUUGGAGCC 2278 AGAAcucAucuuuGGAGccdTsdT
sense 1055-1074 2279 GGCUCCAAAGAUGAGUUCU 2280
GGCUCcAAAGAUGAGUUCUdTsdT antis 1058-1077 2281 ACUCAUCUUUGGAGCCACA
2282 AcucAucuuuGGAGccAcAdTsdT sense 1058-1077 2283
UGUGGCUCCAAAGAUGAGU 2284 UGUGGCUCcAAAGAUGAGUdTsdT antis 1061-1080
2285 CAUCUUUGGAGCCACAGAU 2286 cAucuuuGGAGccAcAGAudTsdT sense
1061-1080 2287 AUCUGUGGCUCCAAAGAUG 2288 AUCUGUGGCUCcAAAGAUGdTsdT
antis 1062-1081 2289 AUCUUUGGAGCCACAGAUU 2290
AucuuuGGAGccAcAGAuudTsdT sense 1062-1081 2291 AAUCUGUGGCUCCAAAGAU
2292 AAUCUGUGGCUCcAAAGAUdTsdT antis 1086-1105 2293
UCGUCCAUCGAUGUGUGGU 2294 ucGuccAucGAuGuGuGGudTsdT sense 1086-1105
2295 ACCACACAUCGAUGGACGA 2296 ACcAcAcAUCGAUGGACGAdTsdT antis
1099-1118 2297 UGUGGUCGGCUGGCUGUGU 2298 uGuGGucGGcuGGcuGuGudTsdT
sense 1099-1118 2299 ACACAGCCAGCCGACCACA 2300
AcAcAGCcAGCCGACcAcAdTsdT antis 1100-1119 2301 GUGGUCGGCUGGCUGUGUA
2302 GuGGucGGcuGGcuGuGuAdTsdT sense 1100-1119 2303
UACACAGCCAGCCGACCAC 2304 uAcAcAGCcAGCCGACcACdTsdT antis 1101-1120
2305 UGGUCGGCUGGCUGUGUAC 2306 uGGucGGcuGGcuGuGuAcdTsdT sense
1101-1120 2307 GUACACAGCCAGCCGACCA 2308 GuAcAcAGCcAGCCGACcAdTsdT
antis 1112-1131 2309 CUGUGUACUUGCUGAGCUA 2310
cuGuGuAcuuGcuGAGcuAdTsdT sense 1112-1131 2311 UAGCUCAGCAAGUACACAG
2312 uAGCUcAGcAAGuAcAcAGdTsdT antis 1114-1133 2313
GUGUACUUGCUGAGCUACU 2314 GuGuAcuuGcuGAGcuAcudTsdT sense 1114-1133
2315 AGUAGCUCAGCAAGUACAC 2316 AGuAGCUcAGcAAGuAcACdTsdT antis
1115-1134 2317 UGUACUUGCUGAGCUACUU 2318 uGuAcuuGcuGAGcuAcuudTsdT
sense 1115-1134 2319 AAGUAGCUCAGCAAGUACA 2320
AAGuAGCUcAGcAAGuAcAdTsdT antis 1119-1138 2321 CUUGCUGAGCUACUUCUCG
2322 cuuGcuGAGcuAcuucucGdTsdT sense 1119-1138 2323
CGAGAAGUAGCUCAGCAAG 2324 CGAGAAGuAGCUcAGcAAGdTsdT antis 1126-1145
2325 AGCUACUUCUCGGCCAGCC 2326 AGcuAcuucucGGccAGccdTsdT sense
1126-1145 2327 GGCUGGCCGAGAAGUAGCU 2328 GGCUGGCCGAGAAGuAGCUdTsdT
antis 1139-1158 2329 CCAGCCCAUCUUCCCUGGG 2330
ccAGcccAucuucccuGGGdTsdT sense 1139-1158 2331 CCCAGGGAAGAUGGGCUGG
2332 CCcAGGGAAGAUGGGCUGGdTsdT antis 1146-1165 2333
AUCUUCCCUGGGGACAGUG 2334 AucuucccuGGGGAcAGuGdTsdT sense 1146-1165
2335 CACUGUCCCCAGGGAAGAU 2336 cACUGUCCCcAGGGAAGAUdTsdT antis
1224-1243 2337 CGAGAGAUGAACCCUAACU 2338 cGAGAGAuGAAcccuAAcudTsdT
sense 1224-1243 2339 AGUUAGGGUUCAUCUCUCG 2340
AGUuAGGGUUcAUCUCUCGdTsdT antis 1263-1282 2341 CAGAUCAAAGCUCACCCUU
2342 cAGAucAAAGcucAcccuudTsdT sense 1263-1282 2343
AAGGGUGAGCUUUGAUCUG 2344 AAGGGUGAGCUUUGAUCUGdTsdT antis 1264-1283
2345 AGAUCAAAGCUCACCCUUG 2346 AGAucAAAGcucAcccuuGdTsdT sense
1264-1283 2347 CAAGGGUGAGCUUUGAUCU 2348 cAAGGGUGAGCUUUGAUCUdTsdT
antis 1267-1286 2349 UCAAAGCUCACCCUUGGAC 2350
ucAAAGcucAcccuuGGAcdTsdT sense 1267-1286 2351 GUCCAAGGGUGAGCUUUGA
2352 GUCcAAGGGUGAGCUUUGAdTsdT antis 1285-1304 2353
CAAAGGUGUUCAAAUCUUC 2354 cAAAGGuGuucAAAucuucdTsdT sense 1285-1304
2355 GAAGAUUUGAACACCUUUG 2356 GAAGAUUUGAAcACCUUUGdTsdT antis
1286-1305 2357 AAAGGUGUUCAAAUCUUCA 2358 AAAGGuGuucAAAucuucAdTsdT
sense 1286-1305 2359 UGAAGAUUUGAACACCUUU 2360
UGAAGAUUUGAAcACCUUUdTsdT antis 1295-1314 2361 CAAAUCUUCAAAGACACCA
2362 cAAAucuucAAAGAcAccAdTsdT sense 1295-1314 2363
UGGUGUCUUUGAAGAUUUG 2364 UGGUGUCUUUGAAGAUUUGdTsdT antis 1304-1323
2365 AAAGACACCACCUGAGGCC 2366 AAAGAcAccAccuGAGGccdTsdT sense
1304-1323 2367 GGCCUCAGGUGGUGUCUUU 2368 GGCCUcAGGUGGUGUCUUUdTsdT
antis 1306-1325 2369 AGACACCACCUGAGGCCAU 2370
AGAcAccAccuGAGGccAudTsdT sense 1306-1325 2371 AUGGCCUCAGGUGGUGUCU
2372 AUGGCCUcAGGUGGUGUCUdTsdT antis 1307-1326 2373
GACACCACCUGAGGCCAUU 2374 GAcAccAccuGAGGccAuudTsdT sense 1307-1326
2375 AAUGGCCUCAGGUGGUGUC 2376 AAUGGCCUcAGGUGGUGUCdTsdT antis
1310-1329 2377 ACCACCUGAGGCCAUUGCA 2378 AccAccuGAGGccAuuGcAdTsdT
sense 1310-1329 2379 UGCAAUGGCCUCAGGUGGU 2380
UGcAAUGGCCUcAGGUGGUdTsdT antis 1313-1332 2381 ACCUGAGGCCAUUGCACUC
2382 AccuGAGGccAuuGcAcucdTsdT sense 1313-1332 2383
GAGUGCAAUGGCCUCAGGU 2384 GAGUGcAAUGGCCUcAGGUdTsdT antis 1315-1334
2385 CUGAGGCCAUUGCACUCUG 2386 cuGAGGccAuuGcAcucuGdTsdT sense
1315-1334 2387 CAGAGUGCAAUGGCCUCAG 2388 cAGAGUGcAAUGGCCUcAGdTsdT
antis 1322-1341 2389 CAUUGCACUCUGCUCUAGC 2390
cAuuGcAcucuGcucuAGcdTsdT sense 1322-1341 2391 GCUAGAGCAGAGUGCAAUG
2392 GCuAGAGcAGAGUGcAAUGdTsdT antis 1330-1349 2393
UCUGCUCUAGCCUACUGGA 2394 ucuGcucuAGccuAcuGGAdTsdT sense 1330-1349
2395 UCCAGUAGGCUAGAGCAGA 2396 UCcAGuAGGCuAGAGcAGAdTsdT antis
1344-1363 2397 CUGGAGUACACGCCAUCCU 2398 cuGGAGuAcAcGccAuccudTsdT
sense 1344-1363 2399 AGGAUGGCGUGUACUCCAG 2400
AGGAUGGCGUGuACUCcAGdTsdT antis 1347-1366 2401 GAGUACACGCCAUCCUCAA
2402 GAGuAcAcGccAuccucAAdTsdT sense 1347-1366 2403
UUGAGGAUGGCGUGUACUC 2404 UUGAGGAUGGCGUGuACUCdTsdT antis 1350-1369
2405 UACACGCCAUCCUCAAGGC 2406 uAcAcGccAuccucAAGGcdTsdT sense
1350-1369 2407 GCCUUGAGGAUGGCGUGUA 2408 GCCUUGAGGAUGGCGUGuAdTsdT
antis 1366-1385 2409 GGCUCUCCCCACUCGAGGC 2410
GGcucuccccAcucGAGGcdTsdT sense 1366-1385 2411 GCCUCGAGUGGGGAGAGCC
2412 GCCUCGAGUGGGGAGAGCCdTsdT antis 1367-1386 2413
GCUCUCCCCACUCGAGGCU 2414 GcucuccccAcucGAGGcudTsdT sense 1367-1386
2415 AGCCUCGAGUGGGGAGAGC 2416 AGCCUCGAGUGGGGAGAGCdTsdT antis
1368-1387 2417 CUCUCCCCACUCGAGGCUU 2418 cucuccccAcucGAGGcuudTsdT
sense 1368-1387 2419 AAGCCUCGAGUGGGGAGAG 2420
AAGCCUCGAGUGGGGAGAGdTsdT antis 1403-1422 2421 CGAUGAACUGCGGAGACUC
2422 cGAuGAAcuGcGGAGAcucdTsdT sense 1403-1422 2423
GAGUCUCCGCAGUUCAUCG 2424 GAGUCUCCGcAGUUcAUCGdTsdT antis 1412-1431
2425 GCGGAGACUCGGAGCCCAG 2426 GcGGAGAcucGGAGcccAGdTsdT sense
1412-1431 2427 CUGGGCUCCGAGUCUCCGC 2428 CUGGGCUCCGAGUCUCCGCdTsdT
antis 1413-1432 2429 CGGAGACUCGGAGCCCAGC 2430
cGGAGAcucGGAGcccAGcdTsdT sense 1413-1432 2431 GCUGGGCUCCGAGUCUCCG
2432 GCUGGGCUCCGAGUCUCCGdTsdT antis 1414-1433 2433
GGAGACUCGGAGCCCAGCU 2434 GGAGAcucGGAGcccAGcudTsdT sense 1414-1433
2435 AGCUGGGCUCCGAGUCUCC 2436 AGCUGGGCUCCGAGUCUCCdTsdT antis
1416-1435 2437 AGACUCGGAGCCCAGCUCC 2438 AGAcucGGAGcccAGcuccdTsdT
sense 1416-1435 2439 GGAGCUGGGCUCCGAGUCU 2440
GGAGCUGGGCUCCGAGUCUdTsdT antis 1418-1437 2441 ACUCGGAGCCCAGCUCCCC
2442 AcucGGAGcccAGcuccccdTsdT sense 1418-1437 2443
GGGGAGCUGGGCUCCGAGU 2444 GGGGAGCUGGGCUCCGAGUdTsdT antis 1420-1439
2445 UCGGAGCCCAGCUCCCCAA 2446 ucGGAGcccAGcuccccAAdTsdT sense
1420-1439 2447 UUGGGGAGCUGGGCUCCGA 2448 UUGGGGAGCUGGGCUCCGAdTsdT
antis 1438-1457 2449 ACGACCGCCCGCUUCCCCC 2450
AcGAccGcccGcuucccccdTsdT sense 1438-1457 2451 GGGGGAAGCGGGCGGUCGU
2452 GGGGGAAGCGGGCGGUCGUdTsdT antis 1447-1466 2453
CGCUUCCCCCCCUGUUCAA 2454 cGcuucccccccuGuucAAdTsdT sense 1447-1466
2455 UUGAACAGGGGGGGAAGCG 2456 UUGAAcAGGGGGGGAAGCGdTsdT antis
1471-1490 2457 GUCCUGGUGAACUGUCCAU 2458 GuccuGGuGAAcuGuccAudTsdT
sense 1471-1490 2459 AUGGACAGUUCACCAGGAC 2460
AUGGAcAGUUcACcAGGACdTsdT antis 1476-1495 2461 GGUGAACUGUCCAUCCAAC
2462 GGuGAAcuGuccAuccAAcdTsdT sense 1476-1495 2463
GUUGGAUGGACAGUUCACC 2464 GUUGGAUGGAcAGUUcACCdTsdT antis 1477-1496
2465 GUGAACUGUCCAUCCAACC 2466 GuGAAcuGuccAuccAAccdTsdT sense
1477-1496 2467 GGUUGGAUGGACAGUUCAC 2468 GGUUGGAUGGAcAGUUcACdTsdT
antis 1486-1505 2469 CCAUCCAACCAUCUCUCAA 2470
ccAuccAAccAucucucAAdTsdT sense 1486-1505 2471 UUGAGAGAUGGUUGGAUGG
2472 UUGAGAGAUGGUUGGAUGGdTsdT antis 1487-1506 2473
CAUCCAACCAUCUCUCAAU 2474 cAuccAAccAucucucAAudTsdT sense 1487-1506
2475 AUUGAGAGAUGGUUGGAUG 2476 AUUGAGAGAUGGUUGGAUGdTsdT antis
1491-1510 2477 CAACCAUCUCUCAAUGCCA 2478 cAAccAucucucAAuGccAdTsdT
sense 1491-1510 2479 UGGCAUUGAGAGAUGGUUG 2480
UGGcAUUGAGAGAUGGUUGdTsdT antis 1492-1511 2481 AACCAUCUCUCAAUGCCAU
2482 AAccAucucucAAuGccAudTsdT sense 1492-1511 2483
AUGGCAUUGAGAGAUGGUU 2484 AUGGcAUUGAGAGAUGGUUdTsdT antis 1493-1512
2485 ACCAUCUCUCAAUGCCAUU 2486 AccAucucucAAuGccAuudTsdT sense
1493-1512 2487 AAUGGCAUUGAGAGAUGGU 2488 AAUGGcAUUGAGAGAUGGUdTsdT
antis 1551-1570 2489 UCUCCCCUCACCACUUCCU 2490
ucuccccucAccAcuuccudTsdT sense 1551-1570 2491 AGGAAGUGGUGAGGGGAGA
2492 AGGAAGUGGUGAGGGGAGAdTsdT antis 1553-1572 2493
UCCCCUCACCACUUCCUAC 2494 uccccucAccAcuuccuAcdTsdT sense 1553-1572
2495 GUAGGAAGUGGUGAGGGGA 2496 GuAGGAAGUGGUGAGGGGAdTsdT antis
1556-1575 2497 CCUCACCACUUCCUACAAC 2498 ccucAccAcuuccuAcAAcdTsdT
sense
1556-1575 2499 GUUGUAGGAAGUGGUGAGG 2500 GUUGuAGGAAGUGGUGAGGdTsdT
antis 1560-1579 2501 ACCACUUCCUACAACCCAU 2502
AccAcuuccuAcAAcccAudTsdT sense 1560-1579 2503 AUGGGUUGUAGGAAGUGGU
2504 AUGGGUUGuAGGAAGUGGUdTsdT antis 1561-1580 2505
CCACUUCCUACAACCCAUC 2506 ccAcuuccuAcAAcccAucdTsdT sense 1561-1580
2507 GAUGGGUUGUAGGAAGUGG 2508 GAUGGGUUGuAGGAAGUGGdTsdT antis
1562-1581 2509 CACUUCCUACAACCCAUCC 2510 cAcuuccuAcAAcccAuccdTsdT
sense 1562-1581 2511 GGAUGGGUUGUAGGAAGUG 2512
GGAUGGGUUGuAGGAAGUGdTsdT antis 1564-1583 2513 CUUCCUACAACCCAUCCUC
2514 cuuccuAcAAcccAuccucdTsdT sense 1564-1583 2515
GAGGAUGGGUUGUAGGAAG 2516 GAGGAUGGGUUGuAGGAAGdTsdT antis 1565-1584
2517 UUCCUACAACCCAUCCUCA 2518 uuccuAcAAcccAuccucAdTsdT sense
1565-1584 2519 UGAGGAUGGGUUGUAGGAA 2520 UGAGGAUGGGUUGuAGGAAdTsdT
antis 1568-1587 2521 CUACAACCCAUCCUCACAA 2522
cuAcAAcccAuccucAcAAdTsdT sense 1568-1587 2523 UUGUGAGGAUGGGUUGUAG
2524 UUGUGAGGAUGGGUUGuAGdTsdT antis 1569-1588 2525
UACAACCCAUCCUCACAAG 2526 uAcAAcccAuccucAcAAGdTsdT sense 1569-1588
2527 CUUGUGAGGAUGGGUUGUA 2528 CUUGUGAGGAUGGGUUGuAdTsdT antis
1572-1591 2529 AACCCAUCCUCACAAGCUU 2530 AAcccAuccucAcAAGcuudTsdT
sense 1572-1591 2531 AAGCUUGUGAGGAUGGGUU 2532
AAGCUUGUGAGGAUGGGUUdTsdT antis 1573-1592 2533 ACCCAUCCUCACAAGCUUU
2534 AcccAuccucAcAAGcuuudTsdT sense 1573-1592 2535
AAAGCUUGUGAGGAUGGGU 2536 AAAGCUUGUGAGGAUGGGUdTsdT antis 1590-1609
2537 UUAACUGAAGCUCAGACUG 2538 uuAAcuGAAGcucAGAcuGdTsdT sense
1590-1609 2539 CAGUCUGAGCUUCAGUUAA 2540 cAGUCUGAGCUUcAGUuAAdTsdT
antis 1591-1610 2541 UAACUGAAGCUCAGACUGG 2542
uAAcuGAAGcucAGAcuGGdTsdT sense 1591-1610 2543 CCAGUCUGAGCUUCAGUUA
2544 CcAGUCUGAGCUUcAGUuAdTsdT antis 1592-1611 2545
AACUGAAGCUCAGACUGGC 2546 AAcuGAAGcucAGAcuGGcdTsdT sense 1592-1611
2547 GCCAGUCUGAGCUUCAGUU 2548 GCcAGUCUGAGCUUcAGUUdTsdT antis
1593-1612 2549 ACUGAAGCUCAGACUGGCC 2550 AcuGAAGcucAGAcuGGccdTsdT
sense 1593-1612 2551 GGCCAGUCUGAGCUUCAGU 2552
GGCcAGUCUGAGCUUcAGUdTsdT antis 1595-1614 2553 UGAAGCUCAGACUGGCCAA
2554 uGAAGcucAGAcuGGccAAdTsdT sense 1595-1614 2555
UUGGCCAGUCUGAGCUUCA 2556 UUGGCcAGUCUGAGCUUcAdTsdT antis 1601-1620
2557 UCAGACUGGCCAAGAUUGG 2558 ucAGAcuGGccAAGAuuGGdTsdT sense
1601-1620 2559 CCAAUCUUGGCCAGUCUGA 2560 CcAAUCUUGGCcAGUCUGAdTsdT
antis 1606-1625 2561 CUGGCCAAGAUUGGCAGCC 2562
cuGGccAAGAuuGGcAGccdTsdT sense 1606-1625 2563 GGCUGCCAAUCUUGGCCAG
2564 GGCUGCcAAUCUUGGCcAGdTsdT antis 1610-1629 2565
CCAAGAUUGGCAGCCAUCU 2566 ccAAGAuuGGcAGccAucudTsdT sense 1610-1629
2567 AGAUGGCUGCCAAUCUUGG 2568 AGAUGGCUGCcAAUCUUGGdTsdT antis
1614-1633 2569 GAUUGGCAGCCAUCUGAUG 2570 GAuuGGcAGccAucuGAuGdTsdT
sense 1614-1633 2571 CAUCAGAUGGCUGCCAAUC 2572
cAUcAGAUGGCUGCcAAUCdTsdT antis 1650-1669 2573 GCUAGCUCUUCCUGAGGGC
2574 GcuAGcucuuccuGAGGGcdTsdT sense 1650-1669 2575
GCCCUCAGGAAGAGCUAGC 2576 GCCCUcAGGAAGAGCuAGCdTsdT antis 1654-1673
2577 GCUCUUCCUGAGGGCCCCA 2578 GcucuuccuGAGGGccccAdTsdT sense
1654-1673 2579 UGGGGCCCUCAGGAAGAGC 2580 UGGGGCCCUcAGGAAGAGCdTsdT
antis 1657-1676 2581 CUUCCUGAGGGCCCCACCG 2582
cuuccuGAGGGccccAccGdTsdT sense 1657-1676 2583 CGGUGGGGCCCUCAGGAAG
2584 CGGUGGGGCCCUcAGGAAGdTsdT antis 1799-1818 2585
CAUCUAGGCCUCCCUCAGC 2586 cAucuAGGccucccucAGcdTsdT sense 1799-1818
2587 GCUGAGGGAGGCCUAGAUG 2588 GCUGAGGGAGGCCuAGAUGdTsdT antis
1801-1820 2589 UCUAGGCCUCCCUCAGCAG 2590 ucuAGGccucccucAGcAGdTsdT
sense 1801-1820 2591 CUGCUGAGGGAGGCCUAGA 2592
CUGCUGAGGGAGGCCuAGAdTsdT antis 1839-1858 2593 UUUUUAAAGAGGAUUUUAA
2594 uuuuuAAAGAGGAuuuuAAdTsdT sense 1839-1858 2595
UUAAAAUCCUCUUUAAAAA 2596 UuAAAAUCCUCUUuAAAAAdTsdT antis 1840-1859
2597 UUUUAAAGAGGAUUUUAAC 2598 uuuuAAAGAGGAuuuuAAcdTsdT sense
1840-1859 2599 GUUAAAAUCCUCUUUAAAA 2600 GUuAAAAUCCUCUUuAAAAdTsdT
antis 1841-1860 2601 UUUAAAGAGGAUUUUAACU 2602
uuuAAAGAGGAuuuuAAcudTsdT sense 1841-1860 2603 AGUUAAAAUCCUCUUUAAA
2604 AGUuAAAAUCCUCUUuAAAdTsdT antis 1842-1861 2605
UUAAAGAGGAUUUUAACUG 2606 uuAAAGAGGAuuuuAAcuGdTsdT sense 1842-1861
2607 CAGUUAAAAUCCUCUUUAA 2608 cAGUuAAAAUCCUCUUuAAdTsdT antis
1843-1862 2609 UAAAGAGGAUUUUAACUGU 2610 uAAAGAGGAuuuuAAcuGudTsdT
sense 1843-1862 2611 ACAGUUAAAAUCCUCUUUA 2612
AcAGUuAAAAUCCUCUUuAdTsdT antis 1845-1864 2613 AAGAGGAUUUUAACUGUUU
2614 AAGAGGAuuuuAAcuGuuudTsdT sense 1845-1864 2615
AAACAGUUAAAAUCCUCUU 2616 AAAcAGUuAAAAUCCUCUUdTsdT antis 1849-1868
2617 GGAUUUUAACUGUUUGUAG 2618 GGAuuuuAAcuGuuuGuAGdTsdT sense
1849-1868 2619 CUACAAACAGUUAAAAUCC 2620 CuAcAAAcAGUuAAAAUCCdTsdT
antis 1858-1877 2621 CUGUUUGUAGGGGAGGGGA 2622
cuGuuuGuAGGGGAGGGGAdTsdT sense 1858-1877 2623 UCCCCUCCCCUACAAACAG
2624 UCCCCUCCCCuAcAAAcAGdTsdT antis 1859-1878 2625
UGUUUGUAGGGGAGGGGAG 2626 uGuuuGuAGGGGAGGGGAGdTsdT sense 1859-1878
2627 CUCCCCUCCCCUACAAACA 2628 CUCCCCUCCCCuAcAAAcAdTsdT antis
1862-1881 2629 UUGUAGGGGAGGGGAGAAA 2630 uuGuAGGGGAGGGGAGAAAdTsdT
sense 1862-1881 2631 UUUCUCCCCUCCCCUACAA 2632
UUUCUCCCCUCCCCuAcAAdTsdT antis 1863-1882 2633 UGUAGGGGAGGGGAGAAAA
2634 uGuAGGGGAGGGGAGAAAAdTsdT sense 1863-1882 2635
UUUUCUCCCCUCCCCUACA 2636 UUUUCUCCCCUCCCCuAcAdTsdT antis 1874-1893
2637 GGAGAAAAGGAAGGACGGG 2638 GGAGAAAAGGAAGGAcGGGdTsdT sense
1874-1893 2639 CCCGUCCUUCCUUUUCUCC 2640 CCCGUCCUUCCUUUUCUCCdTsdT
antis 1875-1894 2641 GAGAAAAGGAAGGACGGGG 2642
GAGAAAAGGAAGGAcGGGGdTsdT sense 1875-1894 2643 CCCCGUCCUUCCUUUUCUC
2644 CCCCGUCCUUCCUUUUCUCdTsdT antis 1876-1895 2645
AGAAAAGGAAGGACGGGGU 2646 AGAAAAGGAAGGAcGGGGudTsdT sense 1876-1895
2647 ACCCCGUCCUUCCUUUUCU 2648 ACCCCGUCCUUCCUUUUCUdTsdT antis
1878-1897 2649 AAAAGGAAGGACGGGGUUU 2650 AAAAGGAAGGAcGGGGuuudTsdT
sense 1878-1897 2651 AAACCCCGUCCUUCCUUUU 2652
AAACCCCGUCCUUCCUUUUdTsdT antis 1898-1917 2653 GGGGUGUGAGGACCUUCUA
2654 GGGGuGuGAGGAccuucuAdTsdT sense 1898-1917 2655
UAGAAGGUCCUCACACCCC 2656 uAGAAGGUCCUcAcACCCCdTsdT antis 1899-1918
2657 GGGUGUGAGGACCUUCUAC 2658 GGGuGuGAGGAccuucuAcdTsdT sense
1899-1918 2659 GUAGAAGGUCCUCACACCC 2660 GuAGAAGGUCCUcAcACCCdTsdT
antis 1900-1919 2661 GGUGUGAGGACCUUCUACC 2662
GGuGuGAGGAccuucuAccdTsdT sense 1900-1919 2663 GGUAGAAGGUCCUCACACC
2664 GGuAGAAGGUCCUcAcACCdTsdT antis 1902-1921 2665
UGUGAGGACCUUCUACCCC 2666 uGuGAGGAccuucuAccccdTsdT sense 1902-1921
2667 GGGGUAGAAGGUCCUCACA 2668 GGGGuAGAAGGUCCUcAcAdTsdT antis
1903-1922 2669 GUGAGGACCUUCUACCCCC 2670 GuGAGGAccuucuAcccccdTsdT
sense 1903-1922 2671 GGGGGUAGAAGGUCCUCAC 2672
GGGGGuAGAAGGUCCUcACdTsdT antis 1959-1978 2673 CUCCCCCCCUCUCCCAGGU
2674 cucccccccucucccAGGudTsdT sense 1959-1978 2675
ACCUGGGAGAGGGGGGGAG 2676 ACCUGGGAGAGGGGGGGAGdTsdT antis 1964-1983
2677 CCCCUCUCCCAGGUCCCUU 2678 ccccucucccAGGucccuudTsdT sense
1964-1983 2679 AAGGGACCUGGGAGAGGGG 2680 AAGGGACCUGGGAGAGGGGdTsdT
antis 1970-1989 2681 UCCCAGGUCCCUUGUAAAU 2682
ucccAGGucccuuGuAAAudTsdT sense 1970-1989 2683 AUUUACAAGGGACCUGGGA
2684 AUUuAcAAGGGACCUGGGAdTsdT antis 1974-1993 2685
AGGUCCCUUGUAAAUAGAA 2686 AGGucccuuGuAAAuAGAAdTsdT sense 1974-1993
2687 UUCUAUUUACAAGGGACCU 2688 UUCuAUUuAcAAGGGACCUdTsdT antis
1983-2002 2689 GUAAAUAGAACCAGCCCAG 2690 GuAAAuAGAAccAGcccAGdTsdT
sense 1983-2002 2691 CUGGGCUGGUUCUAUUUAC 2692
CUGGGCUGGUUCuAUUuACdTsdT antis 1984-2003 2693 UAAAUAGAACCAGCCCAGC
2694 uAAAuAGAAccAGcccAGcdTsdT sense 1984-2003 2695
GCUGGGCUGGUUCUAUUUA 2696 GCUGGGCUGGUUCuAUUuAdTsdT antis 1994-2013
2697 CAGCCCAGCCCAUCUCUCG 2698 cAGcccAGcccAucucucGdTsdT sense
1994-2013 2699 CGAGAGAUGGGCUGGGCUG 2700 CGAGAGAUGGGCUGGGCUGdTsdT
antis 1995-2014 2701 AGCCCAGCCCAUCUCUCGU 2702
AGcccAGcccAucucucGudTsdT sense 1995-2014 2703 ACGAGAGAUGGGCUGGGCU
2704 ACGAGAGAUGGGCUGGGCUdTsdT antis 1996-2015 2705
GCCCAGCCCAUCUCUCGUC 2706 GcccAGcccAucucucGucdTsdT sense 1996-2015
2707 GACGAGAGAUGGGCUGGGC 2708 GACGAGAGAUGGGCUGGGCdTsdT antis
1998-2017 2709 CCAGCCCAUCUCUCGUCUU 2710 ccAGcccAucucucGucuudTsdT
sense 1998-2017 2711 AAGACGAGAGAUGGGCUGG 2712
AAGACGAGAGAUGGGCUGGdTsdT antis 2016-2035 2713 UCCCUUCCCUGGCCCCCUG
2714 ucccuucccuGGcccccuGdTsdT sense 2016-2035 2715
CAGGGGGCCAGGGAAGGGA 2716 cAGGGGGCcAGGGAAGGGAdTsdT antis 2022-2041
2717 CCCUGGCCCCCUGGGUGUA 2718 cccuGGcccccuGGGuGuAdTsdT sense
2022-2041 2719 UACACCCAGGGGGCCAGGG 2720 uAcACCcAGGGGGCcAGGGdTsdT
antis 2025-2044 2721 UGGCCCCCUGGGUGUAAAU 2722
uGGcccccuGGGuGuAAAudTsdT sense 2025-2044 2723 AUUUACACCCAGGGGGCCA
2724 AUUuAcACCcAGGGGGCcAdTsdT antis 2026-2045 2725
GGCCCCCUGGGUGUAAAUA 2726 GGcccccuGGGuGuAAAuAdTsdT sense 2026-2045
2727 UAUUUACACCCAGGGGGCC 2728 uAUUuAcACCcAGGGGGCCdTsdT antis
2035-2054 2729 GGUGUAAAUAGAUUGUUAU 2730 GGuGuAAAuAGAuuGuuAudTsdT
sense 2035-2054 2731 AUAACAAUCUAUUUACACC 2732
AuAAcAAUCuAUUuAcACCdTsdT antis 2041-2060 2733 AAUAGAUUGUUAUAAUUUU
2734 AAuAGAuuGuuAuAAuuuudTsdT sense 2041-2060 2735
AAAAUUAUAACAAUCUAUU 2736 AAAAUuAuAAcAAUCuAUUdTsdT antis 2047-2066
2737 UUGUUAUAAUUUUUUCUUA 2738 uuGuuAuAAuuuuuucuuAdTsdT sense
2047-2066 2739 UAAGAAAAAAUUAUAACAA 2740 uAAGAAAAAAUuAuAAcAAdTsdT
antis 2057-2076 2741 UUUUUCUUAAAGAAAACGU 2742
uuuuucuuAAAGAAAAcGudTsdT sense 2057-2076 2743 ACGUUUUCUUUAAGAAAAA
2744 ACGUUUUCUUuAAGAAAAAdTsdT antis 2058-2077 2745
UUUUCUUAAAGAAAACGUC 2746 uuuucuuAAAGAAAAcGucdTsdT sense 2058-2077
2747 GACGUUUUCUUUAAGAAAA 2748 GACGUUUUCUUuAAGAAAAdTsdT antis
2060-2079 2749 UUCUUAAAGAAAACGUCAA 2750 uucuuAAAGAAAAcGucAAdTsdT
sense 2060-2079 2751 UUGACGUUUUCUUUAAGAA 2752
UUGACGUUUUCUUuAAGAAdTsdT antis 2066-2085 2753 AAGAAAACGUCAAUUCACA
2754 AAGAAAAcGucAAuucAcAdTsdT sense 2066-2085 2755
UGUGAAUUGACGUUUUCUU 2756 UGUGAAUUGACGUUUUCUUdTsdT antis 2075-2094
2757 UCAAUUCACACCAUUCAAC 2758 ucAAuucAcAccAuucAAcdTsdT sense
2075-2094 2759 GUUGAAUGGUGUGAAUUGA 2760 GUUGAAUGGUGUGAAUUGAdTsdT
antis 2077-2096 2761 AAUUCACACCAUUCAACUU 2762
AAuucAcAccAuucAAcuudTsdT sense 2077-2096 2763 AAGUUGAAUGGUGUGAAUU
2764 AAGUUGAAUGGUGUGAAUUdTsdT antis 2079-2098 2765
UUCACACCAUUCAACUUGC 2766 uucAcAccAuucAAcuuGcdTsdT sense 2079-2098
2767 GCAAGUUGAAUGGUGUGAA 2768 GcAAGUUGAAUGGUGUGAAdTsdT antis
2081-2100 2769 CACACCAUUCAACUUGCCC 2770 cAcAccAuucAAcuuGcccdTsdT
sense 2081-2100 2771 GGGCAAGUUGAAUGGUGUG 2772
GGGcAAGUUGAAUGGUGUGdTsdT antis 2091-2110 2773 AACUUGCCCCCCCCAGCUG
2774 AAcuuGccccccccAGcuGdTsdT sense 2091-2110 2775
CAGCUGGGGGGGGCAAGUU 2776 cAGCUGGGGGGGGcAAGUUdTsdT antis 2092-2111
2777 ACUUGCCCCCCCCAGCUGU 2778 AcuuGccccccccAGcuGudTsdT sense
2092-2111 2779 ACAGCUGGGGGGGGCAAGU 2780 AcAGCUGGGGGGGGcAAGUdTsdT
antis 2096-2115 2781 GCCCCCCCCAGCUGUACCC 2782
GccccccccAGcuGuAcccdTsdT sense 2096-2115 2783 GGGUACAGCUGGGGGGGGC
2784 GGGuAcAGCUGGGGGGGGCdTsdT antis 2097-2116 2785
CCCCCCCCAGCUGUACCCC 2786 ccccccccAGcuGuAccccdTsdT sense 2097-2116
2787 GGGGUACAGCUGGGGGGGG 2788 GGGGuAcAGCUGGGGGGGGdTsdT antis
2098-2117 2789 CCCCCCCAGCUGUACCCCU 2790 cccccccAGcuGuAccccudTsdT
sense 2098-2117 2791 AGGGGUACAGCUGGGGGGG 2792
AGGGGuAcAGCUGGGGGGGdTsdT antis 2099-2118 2793 CCCCCCAGCUGUACCCCUU
2794 ccccccAGcuGuAccccuudTsdT sense 2099-2118 2795
AAGGGGUACAGCUGGGGGG 2796 AAGGGGuAcAGCUGGGGGGdTsdT antis 2100-2119
2797 CCCCCAGCUGUACCCCUUC 2798 cccccAGcuGuAccccuucdTsdT sense
2100-2119 2799 GAAGGGGUACAGCUGGGGG 2800 GAAGGGGuAcAGCUGGGGGdTsdT
antis 2107-2126 2801 CUGUACCCCUUCUUGUCCU 2802
cuGuAccccuucuuGuccudTsdT sense 2107-2126 2803 AGGACAAGAAGGGGUACAG
2804 AGGAcAAGAAGGGGuAcAGdTsdT antis 2108-2127 2805
UGUACCCCUUCUUGUCCUC 2806 uGuAccccuucuuGuccucdTsdT sense 2108-2127
2807 GAGGACAAGAAGGGGUACA 2808 GAGGAcAAGAAGGGGuAcAdTsdT antis
2123-2142 2809 CCUCUGCUCCCAAGGCUUC 2810 ccucuGcucccAAGGcuucdTsdT
sense 2123-2142 2811 GAAGCCUUGGGAGCAGAGG 2812
GAAGCCUUGGGAGcAGAGGdTsdT antis 2124-2143 2813 CUCUGCUCCCAAGGCUUCC
2814 cucuGcucccAAGGcuuccdTsdT sense 2124-2143 2815
GGAAGCCUUGGGAGCAGAG 2816 GGAAGCCUUGGGAGcAGAGdTsdT antis 2151-2170
2817 CCCAUCCUGGAAGGAGGGG 2818 cccAuccuGGAAGGAGGGGdTsdT sense
2151-2170 2819 CCCCUCCUUCCAGGAUGGG 2820 CCCCUCCUUCcAGGAUGGGdTsdT
antis 2157-2176 2821 CUGGAAGGAGGGGAGUAGA 2822
cuGGAAGGAGGGGAGuAGAdTsdT sense 2157-2176 2823 UCUACUCCCCUCCUUCCAG
2824 UCuACUCCCCUCCUUCcAGdTsdT antis 2158-2177 2825
UGGAAGGAGGGGAGUAGAG 2826 uGGAAGGAGGGGAGuAGAGdTsdT sense 2158-2177
2827 CUCUACUCCCCUCCUUCCA 2828 CUCuACUCCCCUCCUUCcAdTsdT antis
2159-2178 2829 GGAAGGAGGGGAGUAGAGA 2830 GGAAGGAGGGGAGuAGAGAdTsdT
sense 2159-2178 2831 UCUCUACUCCCCUCCUUCC 2832
UCUCuACUCCCCUCCUUCCdTsdT antis 2160-2179 2833 GAAGGAGGGGAGUAGAGAG
2834 GAAGGAGGGGAGuAGAGAGdTsdT sense 2160-2179 2835
CUCUCUACUCCCCUCCUUC 2836 CUCUCuACUCCCCUCCUUCdTsdT antis 2165-2184
2837 AGGGGAGUAGAGAGAGUCC 2838 AGGGGAGuAGAGAGAGuccdTsdT sense
2165-2184 2839 GGACUCUCUCUACUCCCCU 2840 GGACUCUCUCuACUCCCCUdTsdT
antis 2166-2185 2841 GGGGAGUAGAGAGAGUCCC 2842
GGGGAGuAGAGAGAGucccdTsdT sense 2166-2185 2843 GGGACUCUCUCUACUCCCC
2844 GGGACUCUCUCuACUCCCCdTsdT antis 2169-2188 2845
GAGUAGAGAGAGUCCCUGG 2846 GAGuAGAGAGAGucccuGGdTsdT sense 2169-2188
2847 CCAGGGACUCUCUCUACUC 2848 CcAGGGACUCUCUCuACUCdTsdT antis
2173-2192 2849 AGAGAGAGUCCCUGGUGUC 2850 AGAGAGAGucccuGGuGucdTsdT
sense 2173-2192 2851 GACACCAGGGACUCUCUCU 2852
GAcACcAGGGACUCUCUCUdTsdT antis 2178-2197 2853 GAGUCCCUGGUGUCUUAGU
2854 GAGucccuGGuGucuuAGudTsdT sense 2178-2197 2855
ACUAAGACACCAGGGACUC 2856 ACuAAGAcACcAGGGACUCdTsdT antis 2179-2198
2857 AGUCCCUGGUGUCUUAGUU 2858 AGucccuGGuGucuuAGuudTsdT sense
2179-2198 2859 AACUAAGACACCAGGGACU 2860 AACuAAGAcACcAGGGACUdTsdT
antis 2182-2201 2861 CCCUGGUGUCUUAGUUUCC 2862
cccuGGuGucuuAGuuuccdTsdT sense 2182-2201 2863 GGAAACUAAGACACCAGGG
2864 GGAAACuAAGAcACcAGGGdTsdT antis 2183-2202 2865
CCUGGUGUCUUAGUUUCCA 2866 ccuGGuGucuuAGuuuccAdTsdT sense 2183-2202
2867 UGGAAACUAAGACACCAGG 2868 UGGAAACuAAGAcACcAGGdTsdT antis
2188-2207 2869 UGUCUUAGUUUCCACAGUA 2870 uGucuuAGuuuccAcAGuAdTsdT
sense 2188-2207 2871 UACUGUGGAAACUAAGACA 2872
uACUGUGGAAACuAAGAcAdTsdT antis 2198-2217 2873 UCCACAGUAAGGUUUGCCU
2874 uccAcAGuAAGGuuuGccudTsdT sense 2198-2217 2875
AGGCAAACCUUACUGUGGA 2876 AGGcAAACCUuACUGUGGAdTsdT antis 2199-2218
2877 CCACAGUAAGGUUUGCCUG 2878 ccAcAGuAAGGuuuGccuGdTsdT sense
2199-2218 2879 CAGGCAAACCUUACUGUGG 2880 cAGGcAAACCUuACUGUGGdTsdT
antis 2200-2219 2881 CACAGUAAGGUUUGCCUGU 2882
cAcAGuAAGGuuuGccuGudTsdT sense 2200-2219 2883 ACAGGCAAACCUUACUGUG
2884 AcAGGcAAACCUuACUGUGdTsdT antis 2201-2220 2885
ACAGUAAGGUUUGCCUGUG 2886 AcAGuAAGGuuuGccuGuGdTsdT sense 2201-2220
2887 CACAGGCAAACCUUACUGU 2888 cAcAGGcAAACCUuACUGUdTsdT antis
2203-2222 2889 AGUAAGGUUUGCCUGUGUA 2890 AGuAAGGuuuGccuGuGuAdTsdT
sense 2203-2222 2891 UACACAGGCAAACCUUACU 2892
uAcAcAGGcAAACCUuACUdTsdT antis 2204-2223 2893 GUAAGGUUUGCCUGUGUAC
2894 GuAAGGuuuGccuGuGuAcdTsdT sense 2204-2223 2895
GUACACAGGCAAACCUUAC 2896 GuAcAcAGGcAAACCUuACdTsdT antis 2205-2224
2897 UAAGGUUUGCCUGUGUACA 2898 uAAGGuuuGccuGuGuAcAdTsdT sense
2205-2224 2899 UGUACACAGGCAAACCUUA 2900 UGuAcAcAGGcAAACCUuAdTsdT
antis 2210-2229 2901 UUUGCCUGUGUACAGACCU 2902
uuuGccuGuGuAcAGAccudTsdT sense 2210-2229 2903 AGGUCUGUACACAGGCAAA
2904 AGGUCUGuAcAcAGGcAAAdTsdT antis 2211-2230 2905
UUGCCUGUGUACAGACCUC 2906 uuGccuGuGuAcAGAccucdTsdT sense 2211-2230
2907 GAGGUCUGUACACAGGCAA 2908 GAGGUCUGuAcAcAGGcAAdTsdT antis
2214-2233 2909 CCUGUGUACAGACCUCUGU 2910 ccuGuGuAcAGAccucuGudTsdT
sense 2214-2233 2911 ACAGAGGUCUGUACACAGG 2912
AcAGAGGUCUGuAcAcAGGdTsdT antis 2215-2234 2913 CUGUGUACAGACCUCUGUU
2914 cuGuGuAcAGAccucuGuudTsdT sense 2215-2234 2915
AACAGAGGUCUGUACACAG 2916 AAcAGAGGUCUGuAcAcAGdTsdT antis 2220-2239
2917 UACAGACCUCUGUUCAAUA 2918 uAcAGAccucuGuucAAuAdTsdT sense
2220-2239 2919 UAUUGAACAGAGGUCUGUA 2920 uAUUGAAcAGAGGUCUGuAdTsdT
antis 2224-2243 2921 GACCUCUGUUCAAUAAAUU 2922
GAccucuGuucAAuAAAuudTsdT sense 2224-2243 2923 AAUUUAUUGAACAGAGGUC
2924 AAUUuAUUGAAcAGAGGUCdTsdT antis 2234-2253 2925
CAAUAAAUUAUUGGCAUGA 2926 cAAuAAAuuAuuGGcAuGAdTsdT sense 2234-2253
2927 UCAUGCCAAUAAUUUAUUG 2928 UcAUGCcAAuAAUUuAUUGdTsdT antis 51-70
2929 CGCGGCGGGCGCUGGGCCG 2930 cGcGGcGGGcGcuGGGccGdTsdT sense 51-70
2931 CGGCCCAGCGCCCGCCGCG 2932 CGGCCcAGCGCCCGCCGCGdTsdT antis
173-192 2933 UGGGCCUGCGCUCGGCGCC 2934 uGGGccuGcGcucGGcGccdTsdT
sense 173-192 2935 GGCGCCGAGCGCAGGCCCA 2936
GGCGCCGAGCGcAGGCCcAdTsdT antis 205-224 2937 GGCCUUCGGGAGGCGGCCC
2938 GGccuucGGGAGGcGGcccdTsdT sense 205-224 2939
GGGCCGCCUCCCGAAGGCC 2940 GGGCCGCCUCCCGAAGGCCdTsdT antis 221-240
2941 CCCUGGGGGCUCGGGCCGG 2942 cccuGGGGGcucGGGccGGdTsdT sense
221-240 2943 CCGGCCCGAGCCCCCAGGG 2944 CCGGCCCGAGCCCCcAGGGdTsdT
antis 224-243 2945 UGGGGGCUCGGGCCGGGCG 2946
uGGGGGcucGGGccGGGcGdTsdT sense 224-243 2947 CGCCCGGCCCGAGCCCCCA
2948 CGCCCGGCCCGAGCCCCcAdTsdT antis 387-406 2949
GGGGGUGGCCCCAGCGGCA 2950 GGGGGuGGccccAGcGGcAdTsdT sense 387-406
2951 UGCCGCUGGGGCCACCCCC 2952 UGCCGCUGGGGCcACCCCCdTsdT antis
392-411 2953 UGGCCCCAGCGGCAGCGGC 2954 uGGccccAGcGGcAGcGGcdTsdT
sense 392-411 2955 GCCGCUGCCGCUGGGGCCA 2956
GCCGCUGCCGCUGGGGCcAdTsdT antis 465-484 2957 AAGCUGGGCCGUGACAGCG
2958 AAGcuGGGccGuGAcAGcGdTsdT sense 465-484 2959
CGCUGUCACGGCCCAGCUU 2960 CGCUGUcACGGCCcAGCUUdTsdT antis 505-524
2961 CCACUGUAGGCCAAGGCCC 2962 ccAcuGuAGGccAAGGcccdTsdT sense
505-524 2963 GGGCCUUGGCCUACAGUGG 2964 GGGCCUUGGCCuAcAGUGGdTsdT
antis 587-606 2965 AGUAUACCAGGCACGGCUG 2966
AGuAuAccAGGcAcGGcuGdTsdT sense 587-606 2967 CAGCCGUGCCUGGUAUACU
2968 cAGCCGUGCCUGGuAuACUdTsdT antis 601-620 2969
GGCUGGCAGAGACGAGGGA 2970 GGcuGGcAGAGAcGAGGGAdTsdT sense 601-620
2971 UCCCUCGUCUCUGCCAGCC 2972 UCCCUCGUCUCUGCcAGCCdTsdT antis
743-762 2973 GAAGAAGGACGAGCUGUAU 2974 GAAGAAGGAcGAGcuGuAudTsdT
sense 743-762 2975 AUACAGCUCGUCCUUCUUC 2976
AuAcAGCUCGUCCUUCUUCdTsdT antis 927-946 2977 AAGCCCCAGAAUUUGCUUG
2978 AAGccccAGAAuuuGcuuGdTsdT sense 927-946 2979
CAAGCAAAUUCUGGGGCUU 2980 cAAGcAAAUUCUGGGGCUUdTsdT antis 932-951
2981 CCAGAAUUUGCUUGUGGAC 2982 ccAGAAuuuGcuuGuGGAcdTsdT sense
932-951 2983 GUCCACAAGCAAAUUCUGG 2984 GUCcAcAAGcAAAUUCUGGdTsdT
antis 1054-1073 2985 CAGAACUCAUCUUUGGAGC 2986
cAGAAcucAucuuuGGAGcdTsdT sense 1054-1073 2987 GCUCCAAAGAUGAGUUCUG
2988 GCUCcAAAGAUGAGUUCUGdTsdT antis 1060-1079 2989
UCAUCUUUGGAGCCACAGA 2990 ucAucuuuGGAGccAcAGAdTsdT sense 1060-1079
2991 UCUGUGGCUCCAAAGAUGA 2992 UCUGUGGCUCcAAAGAUGAdTsdT antis
1068-1087 2993 GGAGCCACAGAUUACACCU 2994 GGAGccAcAGAuuAcAccudTsdT
sense 1068-1087 2995 AGGUGUAAUCUGUGGCUCC 2996
AGGUGuAAUCUGUGGCUCCdTsdT antis 1094-1113 2997 CGAUGUGUGGUCGGCUGGC
2998 cGAuGuGuGGucGGcuGGcdTsdT sense 1094-1113 2999
GCCAGCCGACCACACAUCG 3000 GCcAGCCGACcAcAcAUCGdTsdT antis
1107-1126 3001 GCUGGCUGUGUACUUGCUG 3002 GcuGGcuGuGuAcuuGcuGdTsdT
sense 1107-1126 3003 CAGCAAGUACACAGCCAGC 3004
cAGcAAGuAcAcAGCcAGCdTsdT antis 1108-1127 3005 CUGGCUGUGUACUUGCUGA
3006 cuGGcuGuGuAcuuGcuGAdTsdT sense 1108-1127 3007
UCAGCAAGUACACAGCCAG 3008 UcAGcAAGuAcAcAGCcAGdTsdT antis 1138-1157
3009 GCCAGCCCAUCUUCCCUGG 3010 GccAGcccAucuucccuGGdTsdT sense
1138-1157 3011 CCAGGGAAGAUGGGCUGGC 3012 CcAGGGAAGAUGGGCUGGCdTsdT
antis 1149-1168 3013 UUCCCUGGGGACAGUGGGG 3014
uucccuGGGGAcAGuGGGGdTsdT sense 1149-1168 3015 CCCCACUGUCCCCAGGGAA
3016 CCCcACUGUCCCcAGGGAAdTsdT antis 1474-1493 3017
CUGGUGAACUGUCCAUCCA 3018 cuGGuGAAcuGuccAuccAdTsdT sense 1474-1493
3019 UGGAUGGACAGUUCACCAG 3020 UGGAUGGAcAGUUcACcAGdTsdT antis
1480-1499 3021 AACUGUCCAUCCAACCAUC 3022 AAcuGuccAuccAAccAucdTsdT
sense 1480-1499 3023 GAUGGUUGGAUGGACAGUU 3024
GAUGGUUGGAUGGAcAGUUdTsdT antis 1555-1574 3025 CCCUCACCACUUCCUACAA
3026 cccucAccAcuuccuAcAAdTsdT sense 1555-1574 3027
UUGUAGGAAGUGGUGAGGG 3028 UUGuAGGAAGUGGUGAGGGdTsdT antis 1848-1867
3029 AGGAUUUUAACUGUUUGUA 3030 AGGAuuuuAAcuGuuuGuAdTsdT sense
1848-1867 3031 UACAAACAGUUAAAAUCCU 3032 uAcAAAcAGUuAAAAUCCUdTsdT
antis 2031-2050 3033 CCUGGGUGUAAAUAGAUUG 3034
ccuGGGuGuAAAuAGAuuGdTsdT sense 2031-2050 3035 CAAUCUAUUUACACCCAGG
3036 cAAUCuAUUuAcACCcAGGdTsdT antis 2042-2061 3037
AUAGAUUGUUAUAAUUUUU 3038 AuAGAuuGuuAuAAuuuuudTsdT sense 2042-2061
3039 AAAAAUUAUAACAAUCUAU 3040 AAAAAUuAuAAcAAUCuAUdTsdT antis
2127-2146 3041 UGCUCCCAAGGCUUCCUCC 3042 uGcucccAAGGcuuccuccdTsdT
sense 2127-2146 3043 GGAGGAAGCCUUGGGAGCA 3044
GGAGGAAGCCUUGGGAGcAdTsdT antis 2230-2249 3045 UGUUCAAUAAAUUAUUGGC
3046 uGuucAAuAAAuuAuuGGcdTsdT sense 2230-2249 3047
GCCAAUAAUUUAUUGAACA 3048 GCcAAuAAUUuAUUGAAcAdTsdT antis 48-67 3049
CCCCGCGGCGGGCGCUGGG 3050 ccccGcGGcGGGcGcuGGGdTsdT sense 48-67 3051
CCCAGCGCCCGCCGCGGGG 3052 CCcAGCGCCCGCCGCGGGGdTsdT antis 50-69 3053
CCGCGGCGGGCGCUGGGCC 3054 ccGcGGcGGGcGcuGGGccdTsdT sense 50-69 3055
GGCCCAGCGCCCGCCGCGG 3056 GGCCcAGCGCCCGCCGCGGdTsdT antis 56-75 3057
CGGGCGCUGGGCCGGAGCC 3058 cGGGcGcuGGGccGGAGccdTsdT sense 56-75 3059
GGCUCCGGCCCAGCGCCCG 3060 GGCUCCGGCCcAGCGCCCGdTsdT antis 89-108 3061
GCGGCCUGGAAGAGGCCGG 3062 GcGGccuGGAAGAGGccGGdTsdT sense 89-108 3063
CCGGCCUCUUCCAGGCCGC 3064 CCGGCCUCUUCcAGGCCGCdTsdT antis 91-110 3065
GGCCUGGAAGAGGCCGGAG 3066 GGccuGGAAGAGGccGGAGdTsdT sense 91-110 3067
CUCCGGCCUCUUCCAGGCC 3068 CUCCGGCCUCUUCcAGGCCdTsdT antis 95-114 3069
UGGAAGAGGCCGGAGCCCA 3070 uGGAAGAGGccGGAGcccAdTsdT sense 95-114 3071
UGGGCUCCGGCCUCUUCCA 3072 UGGGCUCCGGCCUCUUCcAdTsdT antis 96-115 3073
GGAAGAGGCCGGAGCCCAG 3074 GGAAGAGGccGGAGcccAGdTsdT sense 96-115 3075
CUGGGCUCCGGCCUCUUCC 3076 CUGGGCUCCGGCCUCUUCCdTsdT antis 103-122
3077 GCCGGAGCCCAGGGGAGGC 3078 GccGGAGcccAGGGGAGGcdTsdT sense
103-122 3079 GCCUCCCCUGGGCUCCGGC 3080 GCCUCCCCUGGGCUCCGGCdTsdT
antis 104-123 3081 CCGGAGCCCAGGGGAGGCG 3082
ccGGAGcccAGGGGAGGcGdTsdT sense 104-123 3083 CGCCUCCCCUGGGCUCCGG
3084 CGCCUCCCCUGGGCUCCGGdTsdT antis 105-124 3085
CGGAGCCCAGGGGAGGCGG 3086 cGGAGcccAGGGGAGGcGGdTsdT sense 105-124
3087 CCGCCUCCCCUGGGCUCCG 3088 CCGCCUCCCCUGGGCUCCGdTsdT antis
134-153 3089 AGCGGCGGGGGCAGCCCAG 3090 AGcGGcGGGGGcAGcccAGdTsdT
sense 134-153 3091 CUGGGCUGCCCCCGCCGCU 3092
CUGGGCUGCCCCCGCCGCUdTsdT antis 147-166 3093 GCCCAGGCAGCCCGAGCCC
3094 GcccAGGcAGcccGAGcccdTsdT sense 147-166 3095
GGGCUCGGGCUGCCUGGGC 3096 GGGCUCGGGCUGCCUGGGCdTsdT antis 158-177
3097 CCGAGCCCCGCGGCCUGGG 3098 ccGAGccccGcGGccuGGGdTsdT sense
158-177 3099 CCCAGGCCGCGGGGCUCGG 3100 CCcAGGCCGCGGGGCUCGGdTsdT
antis 167-186 3101 GCGGCCUGGGCCUGCGCUC 3102
GcGGccuGGGccuGcGcucdTsdT sense 167-186 3103 GAGCGCAGGCCCAGGCCGC
3104 GAGCGcAGGCCcAGGCCGCdTsdT antis 172-191 3105
CUGGGCCUGCGCUCGGCGC 3106 cuGGGccuGcGcucGGcGcdTsdT sense 172-191
3107 GCGCCGAGCGCAGGCCCAG 3108 GCGCCGAGCGcAGGCCcAGdTsdT antis
204-223 3109 GGGCCUUCGGGAGGCGGCC 3110 GGGccuucGGGAGGcGGccdTsdT
sense 204-223 3111 GGCCGCCUCCCGAAGGCCC 3112
GGCCGCCUCCCGAAGGCCCdTsdT antis 209-228 3113 UUCGGGAGGCGGCCCUGGG
3114 uucGGGAGGcGGcccuGGGdTsdT sense 209-228 3115
CCCAGGGCCGCCUCCCGAA 3116 CCcAGGGCCGCCUCCCGAAdTsdT antis 231-250
3117 UCGGGCCGGGCGCGGACCA 3118 ucGGGccGGGcGcGGAccAdTsdT sense
231-250 3119 UGGUCCGCGCCCGGCCCGA 3120 UGGUCCGCGCCCGGCCCGAdTsdT
antis 256-275 3121 UCGCGGAGCCAGGAGGCGG 3122
ucGcGGAGccAGGAGGcGGdTsdT sense 256-275 3123 CCGCCUCCUGGCUCCGCGA
3124 CCGCCUCCUGGCUCCGCGAdTsdT antis 294-313 3125
GGCCCCGGGGGCUCGGCCU 3126 GGccccGGGGGcucGGccudTsdT sense 294-313
3127 AGGCCGAGCCCCCGGGGCC 3128 AGGCCGAGCCCCCGGGGCCdTsdT antis
295-314 3129 GCCCCGGGGGCUCGGCCUC 3130 GccccGGGGGcucGGccucdTsdT
sense 295-314 3131 GAGGCCGAGCCCCCGGGGC 3132
GAGGCCGAGCCCCCGGGGCdTsdT antis 318-337 3133 CCAGGAGGCACUGGCGGCG
3134 ccAGGAGGcAcuGGcGGcGdTsdT sense 318-337 3135
CGCCGCCAGUGCCUCCUGG 3136 CGCCGCcAGUGCCUCCUGGdTsdT antis 369-388
3137 GUGGGAGCCUCGAGCUCCG 3138 GuGGGAGccucGAGcuccGdTsdT sense
369-388 3139 CGGAGCUCGAGGCUCCCAC 3140 CGGAGCUCGAGGCUCCcACdTsdT
antis 386-405 3141 CGGGGGUGGCCCCAGCGGC 3142
cGGGGGuGGccccAGcGGcdTsdT sense 386-405 3143 GCCGCUGGGGCCACCCCCG
3144 GCCGCUGGGGCcACCCCCGdTsdT antis 390-409 3145
GGUGGCCCCAGCGGCAGCG 3146 GGuGGccccAGcGGcAGcGdTsdT sense 390-409
3147 CGCUGCCGCUGGGGCCACC 3148 CGCUGCCGCUGGGGCcACCdTsdT antis
391-410 3149 GUGGCCCCAGCGGCAGCGG 3150 GuGGccccAGcGGcAGcGGdTsdT
sense 391-410 3151 CCGCUGCCGCUGGGGCCAC 3152
CCGCUGCCGCUGGGGCcACdTsdT antis 460-479 3153 GAGUGAAGCUGGGCCGUGA
3154 GAGuGAAGcuGGGccGuGAdTsdT sense 460-479 3155
UCACGGCCCAGCUUCACUC 3156 UcACGGCCcAGCUUcACUCdTsdT antis 491-510
3157 GACCACAGUGGUAGCCACU 3158 GAccAcAGuGGuAGccAcudTsdT sense
491-510 3159 AGUGGCUACCACUGUGGUC 3160 AGUGGCuACcACUGUGGUCdTsdT
antis 494-513 3161 CACAGUGGUAGCCACUGUA 3162
cAcAGuGGuAGccAcuGuAdTsdT sense 494-513 3163 UACAGUGGCUACCACUGUG
3164 uAcAGUGGCuACcACUGUGdTsdT antis 504-523 3165
GCCACUGUAGGCCAAGGCC 3166 GccAcuGuAGGccAAGGccdTsdT sense 504-523
3167 GGCCUUGGCCUACAGUGGC 3168 GGCCUUGGCCuAcAGUGGCdTsdT antis
593-612 3169 CCAGGCACGGCUGGCAGAG 3170 ccAGGcAcGGcuGGcAGAGdTsdT
sense 593-612 3171 CUCUGCCAGCCGUGCCUGG 3172
CUCUGCcAGCCGUGCCUGGdTsdT antis 600-619 3173 CGGCUGGCAGAGACGAGGG
3174 cGGcuGGcAGAGAcGAGGGdTsdT sense 600-619 3175
CCCUCGUCUCUGCCAGCCG 3176 CCCUCGUCUCUGCcAGCCGdTsdT antis 613-632
3177 CGAGGGAACUGGUGGCCAU 3178 cGAGGGAAcuGGuGGccAudTsdT sense
613-632 3179 AUGGCCACCAGUUCCCUCG 3180 AUGGCcACcAGUUCCCUCGdTsdT
antis 650-669 3181 CAAAAGGUUCAAGAACCGA 3182
cAAAAGGuucAAGAAccGAdTsdT sense 650-669 3183 UCGGUUCUUGAACCUUUUG
3184 UCGGUUCUUGAACCUUUUGdTsdT antis 841-860 3185
CUAUCAUCUACAUCAAGGU 3186 cuAucAucuAcAucAAGGudTsdT sense 841-860
3187 ACCUUGAUGUAGAUGAUAG 3188 ACCUUGAUGuAGAUGAuAGdTsdT antis
842-861 3189 UAUCAUCUACAUCAAGGUG 3190 uAucAucuAcAucAAGGuGdTsdT
sense 842-861 3191 CACCUUGAUGUAGAUGAUA 3192
cACCUUGAUGuAGAUGAuAdTsdT antis 895-914 3193 UCCACUCCCAAGGUGUGUG
3194 uccAcucccAAGGuGuGuGdTsdT sense 895-914 3195
CACACACCUUGGGAGUGGA 3196 cAcAcACCUUGGGAGUGGAdTsdT antis 900-919
3197 UCCCAAGGUGUGUGUCACC 3198 ucccAAGGuGuGuGucAccdTsdT sense
900-919 3199 GGUGACACACACCUUGGGA 3200 GGUGAcAcAcACCUUGGGAdTsdT
antis 901-920 3201 CCCAAGGUGUGUGUCACCG 3202
cccAAGGuGuGuGucAccGdTsdT sense 901-920 3203 CGGUGACACACACCUUGGG
3204 CGGUGAcAcAcACCUUGGGdTsdT antis 924-943 3205
AUCAAGCCCCAGAAUUUGC 3206 AucAAGccccAGAAuuuGcdTsdT sense 924-943
3207 GCAAAUUCUGGGGCUUGAU 3208 GcAAAUUCUGGGGCUUGAUdTsdT antis
925-944 3209 UCAAGCCCCAGAAUUUGCU 3210 ucAAGccccAGAAuuuGcudTsdT
sense 925-944 3211 AGCAAAUUCUGGGGCUUGA 3212
AGcAAAUUCUGGGGCUUGAdTsdT antis 926-945 3213 CAAGCCCCAGAAUUUGCUU
3214 cAAGccccAGAAuuuGcuudTsdT sense 926-945 3215
AAGCAAAUUCUGGGGCUUG 3216 AAGcAAAUUCUGGGGCUUGdTsdT antis 953-972
3217 UGACACUGCUGUCCUCAAG 3218 uGAcAcuGcuGuccucAAGdTsdT sense
953-972 3219 CUUGAGGACAGCAGUGUCA 3220 CUUGAGGAcAGcAGUGUcAdTsdT
antis 1053-1072 3221 CCAGAACUCAUCUUUGGAG 3222
ccAGAAcucAucuuuGGAGdTsdT sense 1053-1072 3223 CUCCAAAGAUGAGUUCUGG
3224 CUCcAAAGAUGAGUUCUGGdTsdT antis 1057-1076 3225
AACUCAUCUUUGGAGCCAC 3226 AAcucAucuuuGGAGccAcdTsdT sense 1057-1076
3227 GUGGCUCCAAAGAUGAGUU 3228 GUGGCUCcAAAGAUGAGUUdTsdT antis
1063-1082 3229 UCUUUGGAGCCACAGAUUA 3230 ucuuuGGAGccAcAGAuuAdTsdT
sense 1063-1082 3231 UAAUCUGUGGCUCCAAAGA 3232
uAAUCUGUGGCUCcAAAGAdTsdT antis 1069-1088 3233 GAGCCACAGAUUACACCUC
3234 GAGccAcAGAuuAcAccucdTsdT sense 1069-1088 3235
GAGGUGUAAUCUGUGGCUC 3236 GAGGUGuAAUCUGUGGCUCdTsdT antis 1106-1125
3237 GGCUGGCUGUGUACUUGCU 3238 GGcuGGcuGuGuAcuuGcudTsdT sense
1106-1125 3239 AGCAAGUACACAGCCAGCC 3240 AGcAAGuAcAcAGCcAGCCdTsdT
antis 1118-1137 3241 ACUUGCUGAGCUACUUCUC 3242
AcuuGcuGAGcuAcuucucdTsdT sense 1118-1137 3243 GAGAAGUAGCUCAGCAAGU
3244 GAGAAGuAGCUcAGcAAGUdTsdT antis 1135-1154 3245
UCGGCCAGCCCAUCUUCCC 3246 ucGGccAGcccAucuucccdTsdT sense 1135-1154
3247 GGGAAGAUGGGCUGGCCGA 3248 GGGAAGAUGGGCUGGCCGAdTsdT antis
1137-1156 3249 GGCCAGCCCAUCUUCCCUG 3250 GGccAGcccAucuucccuGdTsdT
sense
1137-1156 3251 CAGGGAAGAUGGGCUGGCC 3252 cAGGGAAGAUGGGCUGGCCdTsdT
antis 1140-1159 3253 CAGCCCAUCUUCCCUGGGG 3254
cAGcccAucuucccuGGGGdTsdT sense 1140-1159 3255 CCCCAGGGAAGAUGGGCUG
3256 CCCcAGGGAAGAUGGGCUGdTsdT antis 1145-1164 3257
CAUCUUCCCUGGGGACAGU 3258 cAucuucccuGGGGAcAGudTsdT sense 1145-1164
3259 ACUGUCCCCAGGGAAGAUG 3260 ACUGUCCCcAGGGAAGAUGdTsdT antis
1150-1169 3261 UCCCUGGGGACAGUGGGGU 3262 ucccuGGGGAcAGuGGGGudTsdT
sense 1150-1169 3263 ACCCCACUGUCCCCAGGGA 3264
ACCCcACUGUCCCcAGGGAdTsdT antis 1270-1289 3265 AAGCUCACCCUUGGACAAA
3266 AAGcucAcccuuGGAcAAAdTsdT sense 1270-1289 3267
UUUGUCCAAGGGUGAGCUU 3268 UUUGUCcAAGGGUGAGCUUdTsdT antis 1296-1315
3269 AAAUCUUCAAAGACACCAC 3270 AAAucuucAAAGAcAccAcdTsdT sense
1296-1315 3271 GUGGUGUCUUUGAAGAUUU 3272 GUGGUGUCUUUGAAGAUUUdTsdT
antis 1297-1316 3273 AAUCUUCAAAGACACCACC 3274
AAucuucAAAGAcAccAccdTsdT sense 1297-1316 3275 GGUGGUGUCUUUGAAGAUU
3276 GGUGGUGUCUUUGAAGAUUdTsdT antis 1302-1321 3277
UCAAAGACACCACCUGAGG 3278 ucAAAGAcAccAccuGAGGdTsdT sense 1302-1321
3279 CCUCAGGUGGUGUCUUUGA 3280 CCUcAGGUGGUGUCUUUGAdTsdT antis
1309-1328 3281 CACCACCUGAGGCCAUUGC 3282 cAccAccuGAGGccAuuGcdTsdT
sense 1309-1328 3283 GCAAUGGCCUCAGGUGGUG 3284
GcAAUGGCCUcAGGUGGUGdTsdT antis 1331-1350 3285 CUGCUCUAGCCUACUGGAG
3286 cuGcucuAGccuAcuGGAGdTsdT sense 1331-1350 3287
CUCCAGUAGGCUAGAGCAG 3288 CUCcAGuAGGCuAGAGcAGdTsdT antis 1422-1441
3289 GGAGCCCAGCUCCCCAACG 3290 GGAGcccAGcuccccAAcGdTsdT sense
1422-1441 3291 CGUUGGGGAGCUGGGCUCC 3292 CGUUGGGGAGCUGGGCUCCdTsdT
antis 1441-1460 3293 ACCGCCCGCUUCCCCCCCU 3294
AccGcccGcuucccccccudTsdT sense 1441-1460 3295 AGGGGGGGAAGCGGGCGGU
3296 AGGGGGGGAAGCGGGCGGUdTsdT antis 1475-1494 3297
UGGUGAACUGUCCAUCCAA 3298 uGGuGAAcuGuccAuccAAdTsdT sense 1475-1494
3299 UUGGAUGGACAGUUCACCA 3300 UUGGAUGGAcAGUUcACcAdTsdT antis
1490-1509 3301 CCAACCAUCUCUCAAUGCC 3302 ccAAccAucucucAAuGccdTsdT
sense 1490-1509 3303 GGCAUUGAGAGAUGGUUGG 3304
GGcAUUGAGAGAUGGUUGGdTsdT antis 1543-1562 3305 GCCCUGCUUCUCCCCUCAC
3306 GcccuGcuucuccccucAcdTsdT sense 1543-1562 3307
GUGAGGGGAGAAGCAGGGC 3308 GUGAGGGGAGAAGcAGGGCdTsdT antis 1544-1563
3309 CCCUGCUUCUCCCCUCACC 3310 cccuGcuucuccccucAccdTsdT sense
1544-1563 3311 GGUGAGGGGAGAAGCAGGG 3312 GGUGAGGGGAGAAGcAGGGdTsdT
antis 1545-1564 3313 CCUGCUUCUCCCCUCACCA 3314
ccuGcuucuccccucAccAdTsdT sense 1545-1564 3315 UGGUGAGGGGAGAAGCAGG
3316 UGGUGAGGGGAGAAGcAGGdTsdT antis 1546-1565 3317
CUGCUUCUCCCCUCACCAC 3318 cuGcuucuccccucAccAcdTsdT sense 1546-1565
3319 GUGGUGAGGGGAGAAGCAG 3320 GUGGUGAGGGGAGAAGcAGdTsdT antis
1550-1569 3321 UUCUCCCCUCACCACUUCC 3322 uucuccccucAccAcuuccdTsdT
sense 1550-1569 3323 GGAAGUGGUGAGGGGAGAA 3324
GGAAGUGGUGAGGGGAGAAdTsdT antis 1559-1578 3325 CACCACUUCCUACAACCCA
3326 cAccAcuuccuAcAAcccAdTsdT sense 1559-1578 3327
UGGGUUGUAGGAAGUGGUG 3328 UGGGUUGuAGGAAGUGGUGdTsdT antis 1574-1593
3329 CCCAUCCUCACAAGCUUUA 3330 cccAuccucAcAAGcuuuAdTsdT sense
1574-1593 3331 UAAAGCUUGUGAGGAUGGG 3332 uAAAGCUUGUGAGGAUGGGdTsdT
antis 1585-1604 3333 AAGCUUUAACUGAAGCUCA 3334
AAGcuuuAAcuGAAGcucAdTsdT sense 1585-1604 3335 UGAGCUUCAGUUAAAGCUU
3336 UGAGCUUcAGUuAAAGCUUdTsdT antis 1598-1617 3337
AGCUCAGACUGGCCAAGAU 3338 AGcucAGAcuGGccAAGAudTsdT sense 1598-1617
3339 AUCUUGGCCAGUCUGAGCU 3340 AUCUUGGCcAGUCUGAGCUdTsdT antis
1599-1618 3341 GCUCAGACUGGCCAAGAUU 3342 GcucAGAcuGGccAAGAuudTsdT
sense 1599-1618 3343 AAUCUUGGCCAGUCUGAGC 3344
AAUCUUGGCcAGUCUGAGCdTsdT antis 1605-1624 3345 ACUGGCCAAGAUUGGCAGC
3346 AcuGGccAAGAuuGGcAGcdTsdT sense 1605-1624 3347
GCUGCCAAUCUUGGCCAGU 3348 GCUGCcAAUCUUGGCcAGUdTsdT antis 1611-1630
3349 CAAGAUUGGCAGCCAUCUG 3350 cAAGAuuGGcAGccAucuGdTsdT sense
1611-1630 3351 CAGAUGGCUGCCAAUCUUG 3352 cAGAUGGCUGCcAAUCUUGdTsdT
antis 1612-1631 3353 AAGAUUGGCAGCCAUCUGA 3354
AAGAuuGGcAGccAucuGAdTsdT sense 1612-1631 3355 UCAGAUGGCUGCCAAUCUU
3356 UcAGAUGGCUGCcAAUCUUdTsdT antis 1651-1670 3357
CUAGCUCUUCCUGAGGGCC 3358 cuAGcucuuccuGAGGGccdTsdT sense 1651-1670
3359 GGCCCUCAGGAAGAGCUAG 3360 GGCCCUcAGGAAGAGCuAGdTsdT antis
1655-1674 3361 CUCUUCCUGAGGGCCCCAC 3362 cucuuccuGAGGGccccAcdTsdT
sense 1655-1674 3363 GUGGGGCCCUCAGGAAGAG 3364
GUGGGGCCCUcAGGAAGAGdTsdT antis 1656-1675 3365 UCUUCCUGAGGGCCCCACC
3366 ucuuccuGAGGGccccAccdTsdT sense 1656-1675 3367
GGUGGGGCCCUCAGGAAGA 3368 GGUGGGGCCCUcAGGAAGAdTsdT antis 1803-1822
3369 UAGGCCUCCCUCAGCAGCC 3370 uAGGccucccucAGcAGccdTsdT sense
1803-1822 3371 GGCUGCUGAGGGAGGCCUA 3372 GGCUGCUGAGGGAGGCCuAdTsdT
antis 1804-1823 3373 AGGCCUCCCUCAGCAGCCU 3374
AGGccucccucAGcAGccudTsdT sense 1804-1823 3375 AGGCUGCUGAGGGAGGCCU
3376 AGGCUGCUGAGGGAGGCCUdTsdT antis 1805-1824 3377
GGCCUCCCUCAGCAGCCUA 3378 GGccucccucAGcAGccuAdTsdT sense 1805-1824
3379 UAGGCUGCUGAGGGAGGCC 3380 uAGGCUGCUGAGGGAGGCCdTsdT antis
1806-1825 3381 GCCUCCCUCAGCAGCCUAA 3382 GccucccucAGcAGccuAAdTsdT
sense 1806-1825 3383 UUAGGCUGCUGAGGGAGGC 3384
UuAGGCUGCUGAGGGAGGCdTsdT antis 1810-1829 3385 CCCUCAGCAGCCUAACCUC
3386 cccucAGcAGccuAAccucdTsdT sense 1810-1829 3387
GAGGUUAGGCUGCUGAGGG 3388 GAGGUuAGGCUGCUGAGGGdTsdT antis 1846-1865
3389 AGAGGAUUUUAACUGUUUG 3390 AGAGGAuuuuAAcuGuuuGdTsdT sense
1846-1865 3391 CAAACAGUUAAAAUCCUCU 3392 cAAAcAGUuAAAAUCCUCUdTsdT
antis 1871-1890 3393 AGGGGAGAAAAGGAAGGAC 3394
AGGGGAGAAAAGGAAGGAcdTsdT sense 1871-1890 3395 GUCCUUCCUUUUCUCCCCU
3396 GUCCUUCCUUUUCUCCCCUdTsdT antis 1873-1892 3397
GGGAGAAAAGGAAGGACGG 3398 GGGAGAAAAGGAAGGAcGGdTsdT sense 1873-1892
3399 CCGUCCUUCCUUUUCUCCC 3400 CCGUCCUUCCUUUUCUCCCdTsdT antis
1877-1896 3401 GAAAAGGAAGGACGGGGUU 3402 GAAAAGGAAGGAcGGGGuudTsdT
sense 1877-1896 3403 AACCCCGUCCUUCCUUUUC 3404
AACCCCGUCCUUCCUUUUCdTsdT antis 1933-1952 3405 CCCUCCCCCAGGCUACCAC
3406 cccucccccAGGcuAccAcdTsdT sense 1933-1952 3407
GUGGUAGCCUGGGGGAGGG 3408 GUGGuAGCCUGGGGGAGGGdTsdT antis 1934-1953
3409 CCUCCCCCAGGCUACCACU 3410 ccucccccAGGcuAccAcudTsdT sense
1934-1953 3411 AGUGGUAGCCUGGGGGAGG 3412 AGUGGuAGCCUGGGGGAGGdTsdT
antis 1940-1959 3413 CCAGGCUACCACUCCUUCC 3414
ccAGGcuAccAcuccuuccdTsdT sense 1940-1959 3415 GGAAGGAGUGGUAGCCUGG
3416 GGAAGGAGUGGuAGCCUGGdTsdT antis 1941-1960 3417
CAGGCUACCACUCCUUCCC 3418 cAGGcuAccAcuccuucccdTsdT sense 1941-1960
3419 GGGAAGGAGUGGUAGCCUG 3420 GGGAAGGAGUGGuAGCCUGdTsdT antis
1945-1964 3421 CUACCACUCCUUCCCUCCC 3422 cuAccAcuccuucccucccdTsdT
sense 1945-1964 3423 GGGAGGGAAGGAGUGGUAG 3424
GGGAGGGAAGGAGUGGuAGdTsdT antis 1946-1965 3425 UACCACUCCUUCCCUCCCC
3426 uAccAcuccuucccuccccdTsdT sense 1946-1965 3427
GGGGAGGGAAGGAGUGGUA 3428 GGGGAGGGAAGGAGUGGuAdTsdT antis 1953-1972
3429 CCUUCCCUCCCCCCCUCUC 3430 ccuucccucccccccucucdTsdT sense
1953-1972 3431 GAGAGGGGGGGAGGGAAGG 3432 GAGAGGGGGGGAGGGAAGGdTsdT
antis 2023-2042 3433 CCUGGCCCCCUGGGUGUAA 3434
ccuGGcccccuGGGuGuAAdTsdT sense 2023-2042 3435 UUACACCCAGGGGGCCAGG
3436 UuAcACCcAGGGGGCcAGGdTsdT antis 2024-2043 3437
CUGGCCCCCUGGGUGUAAA 3438 cuGGcccccuGGGuGuAAAdTsdT sense 2024-2043
3439 UUUACACCCAGGGGGCCAG 3440 UUuAcACCcAGGGGGCcAGdTsdT antis
2040-2059 3441 AAAUAGAUUGUUAUAAUUU 3442 AAAuAGAuuGuuAuAAuuudTsdT
sense 2040-2059 3443 AAAUUAUAACAAUCUAUUU 3444
AAAUuAuAAcAAUCuAUUUdTsdT antis 2043-2062 3445 UAGAUUGUUAUAAUUUUUU
3446 uAGAuuGuuAuAAuuuuuudTsdT sense 2043-2062 3447
AAAAAAUUAUAACAAUCUA 3448 AAAAAAUuAuAAcAAUCuAdTsdT antis 2044-2063
3449 AGAUUGUUAUAAUUUUUUC 3450 AGAuuGuuAuAAuuuuuucdTsdT sense
2044-2063 3451 GAAAAAAUUAUAACAAUCU 3452 GAAAAAAUuAuAAcAAUCUdTsdT
antis 2045-2064 3453 GAUUGUUAUAAUUUUUUCU 3454
GAuuGuuAuAAuuuuuucudTsdT sense 2045-2064 3455 AGAAAAAAUUAUAACAAUC
3456 AGAAAAAAUuAuAAcAAUCdTsdT antis 2046-2065 3457
AUUGUUAUAAUUUUUUCUU 3458 AuuGuuAuAAuuuuuucuudTsdT sense 2046-2065
3459 AAGAAAAAAUUAUAACAAU 3460 AAGAAAAAAUuAuAAcAAUdTsdT antis
2049-2068 3461 GUUAUAAUUUUUUCUUAAA 3462 GuuAuAAuuuuuucuuAAAdTsdT
sense 2049-2068 3463 UUUAAGAAAAAAUUAUAAC 3464
UUuAAGAAAAAAUuAuAACdTsdT antis 2117-2136 3465 UCUUGUCCUCUGCUCCCAA
3466 ucuuGuccucuGcucccAAdTsdT sense 2117-2136 3467
UUGGGAGCAGAGGACAAGA 3468 UUGGGAGcAGAGGAcAAGAdTsdT antis 2118-2137
3469 CUUGUCCUCUGCUCCCAAG 3470 cuuGuccucuGcucccAAGdTsdT sense
2118-2137 3471 CUUGGGAGCAGAGGACAAG 3472 CUUGGGAGcAGAGGAcAAGdTsdT
antis 2129-2148 3473 CUCCCAAGGCUUCCUCCCU 3474
cucccAAGGcuuccucccudTsdT sense 2129-2148 3475 AGGGAGGAAGCCUUGGGAG
3476 AGGGAGGAAGCCUUGGGAGdTsdT antis 2130-2149 3477
UCCCAAGGCUUCCUCCCUC 3478 ucccAAGGcuuccucccucdTsdT sense 2130-2149
3479 GAGGGAGGAAGCCUUGGGA 3480 GAGGGAGGAAGCCUUGGGAdTsdT antis
2133-2152 3481 CAAGGCUUCCUCCCUCUCC 3482 cAAGGcuuccucccucuccdTsdT
sense 2133-2152 3483 GGAGAGGGAGGAAGCCUUG 3484
GGAGAGGGAGGAAGCCUUGdTsdT antis 2134-2153 3485 AAGGCUUCCUCCCUCUCCC
3486 AAGGcuuccucccucucccdTsdT sense 2134-2153 3487
GGGAGAGGGAGGAAGCCUU 3488 GGGAGAGGGAGGAAGCCUUdTsdT antis 2146-2165
3489 CUCUCCCCAUCCUGGAAGG 3490 cucuccccAuccuGGAAGGdTsdT sense
2146-2165 3491 CCUUCCAGGAUGGGGAGAG 3492 CCUUCcAGGAUGGGGAGAGdTsdT
antis 2150-2169 3493 CCCCAUCCUGGAAGGAGGG 3494
ccccAuccuGGAAGGAGGGdTsdT sense 2150-2169 3495 CCCUCCUUCCAGGAUGGGG
3496 CCCUCCUUCcAGGAUGGGGdTsdT antis 2152-2171 3497
CCAUCCUGGAAGGAGGGGA 3498 ccAuccuGGAAGGAGGGGAdTsdT sense 2152-2171
3499 UCCCCUCCUUCCAGGAUGG 3500 UCCCCUCCUUCcAGGAUGGdTsdT antis
2156-2175 3501 CCUGGAAGGAGGGGAGUAG 3502 ccuGGAAGGAGGGGAGuAGdTsdT
sense
2156-2175 3503 CUACUCCCCUCCUUCCAGG 3504 CuACUCCCCUCCUUCcAGGdTsdT
antis 2161-2180 3505 AAGGAGGGGAGUAGAGAGA 3506
AAGGAGGGGAGuAGAGAGAdTsdT sense 2161-2180 3507 UCUCUCUACUCCCCUCCUU
3508 UCUCUCuACUCCCCUCCUUdTsdT antis 2208-2227 3509
GGUUUGCCUGUGUACAGAC 3510 GGuuuGccuGuGuAcAGAcdTsdT sense 2208-2227
3511 GUCUGUACACAGGCAAACC 3512 GUCUGuAcAcAGGcAAACCdTsdT antis
2219-2238 3513 GUACAGACCUCUGUUCAAU 3514 GuAcAGAccucuGuucAAudTsdT
sense 2219-2238 3515 AUUGAACAGAGGUCUGUAC 3516
AUUGAAcAGAGGUCUGuACdTsdT antis 2233-2252 3517 UCAAUAAAUUAUUGGCAUG
3518 ucAAuAAAuuAuuGGcAuGdTsdT sense 2233-2252 3519
CAUGCCAAUAAUUUAUUGA 3520 cAUGCcAAuAAUUuAUUGAdTsdT antis 2-21 3521
UGGUGACAACGAAGCCGAC 3522 uGGuGAcAAcGAAGccGAcdTsdT sense 2-21 3523
GUCGGCUUCGUUGUCACCA 3524 GUCGGCUUCGUUGUcACcAdTsdT antis 138-157
3525 GCGGGGGCAGCCCAGGCAG 3526 GcGGGGGcAGcccAGGcAGdTsdT sense
138-157 3527 CUGCCUGGGCUGCCCCCGC 3528 CUGCCUGGGCUGCCCCCGCdTsdT
antis 381-400 3529 AGCUCCGGGGGUGGCCCCA 3530
AGcuccGGGGGuGGccccAdTsdT sense 381-400 3531 UGGGGCCACCCCCGGAGCU
3532 UGGGGCcACCCCCGGAGCUdTsdT antis 592-611 3533
ACCAGGCACGGCUGGCAGA 3534 AccAGGcAcGGcuGGcAGAdTsdT sense 592-611
3535 UCUGCCAGCCGUGCCUGGU 3536 UCUGCcAGCCGUGCCUGGUdTsdT antis
615-634 3537 AGGGAACUGGUGGCCAUCA 3538 AGGGAAcuGGuGGccAucAdTsdT
sense 615-634 3539 UGAUGGCCACCAGUUCCCU 3540
UGAUGGCcACcAGUUCCCUdTsdT antis 1026-1045 3541 UACAUCUGCUCUCGGUACU
3542 uAcAucuGcucucGGuAcudTsdT sense 1026-1045 3543
AGUACCGAGAGCAGAUGUA 3544 AGuACCGAGAGcAGAUGuAdTsdT antis 1027-1046
3545 ACAUCUGCUCUCGGUACUA 3546 AcAucuGcucucGGuAcuAdTsdT sense
1027-1046 3547 UAGUACCGAGAGCAGAUGU 3548 uAGuACCGAGAGcAGAUGUdTsdT
antis 1105-1124 3549 CGGCUGGCUGUGUACUUGC 3550
cGGcuGGcuGuGuAcuuGcdTsdT sense 1105-1124 3551 GCAAGUACACAGCCAGCCG
3552 GcAAGuAcAcAGCcAGCCGdTsdT antis 1362-1381 3553
UCAAGGCUCUCCCCACUCG 3554 ucAAGGcucuccccAcucGdTsdT sense 1362-1381
3555 CGAGUGGGGAGAGCCUUGA 3556 CGAGUGGGGAGAGCCUUGAdTsdT antis
1440-1459 3557 GACCGCCCGCUUCCCCCCC 3558 GAccGcccGcuucccccccdTsdT
sense 1440-1459 3559 GGGGGGGAAGCGGGCGGUC 3560
GGGGGGGAAGCGGGCGGUCdTsdT antis 2017-2036 3561 CCCUUCCCUGGCCCCCUGG
3562 cccuucccuGGcccccuGGdTsdT sense 2017-2036 3563
CCAGGGGGCCAGGGAAGGG 3564 CcAGGGGGCcAGGGAAGGGdTsdT antis 2018-2037
3565 CCUUCCCUGGCCCCCUGGG 3566 ccuucccuGGcccccuGGGdTsdT sense
2018-2037 3567 CCCAGGGGGCCAGGGAAGG 3568 CCcAGGGGGCcAGGGAAGGdTsdT
antis 2019-2038 3569 CUUCCCUGGCCCCCUGGGU 3570
cuucccuGGcccccuGGGudTsdT sense 2019-2038 3571 ACCCAGGGGGCCAGGGAAG
3572 ACCcAGGGGGCcAGGGAAGdTsdT antis 2148-2167 3573
CUCCCCAUCCUGGAAGGAG 3574 cuccccAuccuGGAAGGAGdTsdT sense 2148-2167
3575 CUCCUUCCAGGAUGGGGAG 3576 CUCCUUCcAGGAUGGGGAGdTsdT antis
2149-2168 3577 UCCCCAUCCUGGAAGGAGG 3578 uccccAuccuGGAAGGAGGdTsdT
sense 2149-2168 3579 CCUCCUUCCAGGAUGGGGA 3580
CCUCCUUCcAGGAUGGGGAdTsdT antis 1335-1354 3581 UCUAGCCUACUGGAGUACA
3582 ucuAGccuAcuGGAGuAcAdTsdT sense 1335-1354 3583
UGUACUCCAGUAGGCUAGA 3584 UGuACUCcAGuAGGCuAGAdTsdT antis 342-361
3585 GCGUCAGUCGGGGCUAUGG 3586 GcGucAGucGGGGcuAuGGdTsdT sense
342-361 3587 CCAUAGCCCCGACUGACGC 3588 CcAuAGCCCCGACUGACGCdTsdT
antis 675-694 3589 CAGAUUAUGCGUAAGCUGG 3590
cAGAuuAuGcGuAAGcuGGdTsdT sense 675-694 3591 CCAGCUUACGCAUAAUCUG
3592 CcAGCUuACGcAuAAUCUGdTsdT antis 1080-1099 3593
UACACCUCGUCCAUCGAUG 3594 uAcAccucGuccAucGAuGdTsdT sense 1080-1099
3595 CAUCGAUGGACGAGGUGUA 3596 cAUCGAUGGACGAGGUGuAdTsdT antis
333-352 3597 GGCGGGAAAGCGUCAGUCG 3598 GGcGGGAAAGcGucAGucGdTsdT
sense 333-352 3599 CGACUGACGCUUUCCCGCC 3600
CGACUGACGCUUUCCCGCCdTsdT antis 475-494 3601 GUGACAGCGGGAAGGUGAC
3602 GuGAcAGcGGGAAGGuGAcdTsdT sense 475-494 3603
GUCACCUUCCCGCUGUCAC 3604 GUcACCUUCCCGCUGUcACdTsdT antis 533-552
3605 CCAAGAAGUGGCUUACACU 3606 ccAAGAAGuGGcuuAcAcudTsdT sense
533-552 3607 AGUGUAAGCCACUUCUUGG 3608 AGUGuAAGCcACUUCUUGGdTsdT
antis 746-765 3609 GAAGGACGAGCUGUAUUUG 3610
GAAGGAcGAGcuGuAuuuGdTsdT sense 746-765 3611 CAAAUACAGCUCGUCCUUC
3612 cAAAuAcAGCUCGUCCUUCdTsdT antis 747-766 3613
AAGGACGAGCUGUAUUUGA 3614 AAGGAcGAGcuGuAuuuGAdTsdT sense 747-766
3615 UCAAAUACAGCUCGUCCUU 3616 UcAAAuAcAGCUCGUCCUUdTsdT antis
830-849 3617 GCUGAUCACCCCUAUCAUC 3618 GcuGAucAccccuAucAucdTsdT
sense 830-849 3619 GAUGAUAGGGGUGAUCAGC 3620
GAUGAuAGGGGUGAUcAGCdTsdT antis 1334-1353 3621 CUCUAGCCUACUGGAGUAC
3622 cucuAGccuAcuGGAGuAcdTsdT sense 1334-1353 3623
GUACUCCAGUAGGCUAGAG 3624 GuACUCcAGuAGGCuAGAGdTsdT antis 497-516
3625 AGUGGUAGCCACUGUAGGC 3626 AGuGGuAGccAcuGuAGGcdTsdT sense
497-516 3627 GCCUACAGUGGCUACCACU 3628 GCCuAcAGUGGCuACcACUdTsdT
antis 1641-1660 3629 GCUACCCUCGCUAGCUCUU 3630
GcuAcccucGcuAGcucuudTsdT sense 1641-1660 3631 AAGAGCUAGCGAGGGUAGC
3632 AAGAGCuAGCGAGGGuAGCdTsdT antis 1642-1661 3633
CUACCCUCGCUAGCUCUUC 3634 cuAcccucGcuAGcucuucdTsdT sense 1642-1661
3635 GAAGAGCUAGCGAGGGUAG 3636 GAAGAGCuAGCGAGGGuAGdTsdT antis
676-695 3637 AGAUUAUGCGUAAGCUGGA 3638 AGAuuAuGcGuAAGcuGGAdTsdT
sense 676-695 3639 UCCAGCUUACGCAUAAUCU 3640
UCcAGCUuACGcAuAAUCUdTsdT antis 1128-1147 3641 CUACUUCUCGGCCAGCCCA
3642 cuAcuucucGGccAGcccAdTsdT sense 1128-1147 3643
UGGGCUGGCCGAGAAGUAG 3644 UGGGCUGGCCGAGAAGuAGdTsdT antis 40-59 3645
CCGGCGUGCCCCGCGGCGG 3646 ccGGcGuGccccGcGGcGGdTsdT sense 40-59 3647
CCGCCGCGGGGCACGCCGG 3648 CCGCCGCGGGGcACGCCGGdTsdT antis 199-218
3649 GCGGCGGGCCUUCGGGAGG 3650 GcGGcGGGccuucGGGAGGdTsdT sense
199-218 3651 CCUCCCGAAGGCCCGCCGC 3652 CCUCCCGAAGGCCCGCCGCdTsdT
antis 222-241 3653 CCUGGGGGCUCGGGCCGGG 3654
ccuGGGGGcucGGGccGGGdTsdT sense 222-241 3655 CCCGGCCCGAGCCCCCAGG
3656 CCCGGCCCGAGCCCCcAGGdTsdT antis 343-362 3657
CGUCAGUCGGGGCUAUGGG 3658 cGucAGucGGGGcuAuGGGdTsdT sense 343-362
3659 CCCAUAGCCCCGACUGACG 3660 CCcAuAGCCCCGACUGACGdTsdT antis
437-456 3661 GGGCACUAGCUUCCCGCCG 3662 GGGcAcuAGcuucccGccGdTsdT
sense 437-456 3663 CGGCGGGAAGCUAGUGCCC 3664
CGGCGGGAAGCuAGUGCCCdTsdT antis 538-557 3665 AAGUGGCUUACACUGACAU
3666 AAGuGGcuuAcAcuGAcAudTsdT sense 538-557 3667
AUGUCAGUGUAAGCCACUU 3668 AUGUcAGUGuAAGCcACUUdTsdT antis 663-682
3669 AACCGAGAACUGCAGAUUA 3670 AAccGAGAAcuGcAGAuuAdTsdT sense
663-682 3671 UAAUCUGCAGUUCUCGGUU 3672 uAAUCUGcAGUUCUCGGUUdTsdT
antis 887-906 3673 GGCCUACAUCCACUCCCAA 3674
GGccuAcAuccAcucccAAdTsdT sense 687-906 3675 UUGGGAGUGGAUGUAGGCC
3676 UUGGGAGUGGAUGuAGGCCdTsdT antis 997-1016 3677
AGCUGGUUCGGGGGGAGCC 3678 AGcuGGuucGGGGGGAGccdTsdT sense 997-1016
3679 GGCUCCCCCCGAACCAGCU 3680 GGCUCCCCCCGAACcAGCUdTsdT antis
1079-1098 3681 UUACACCUCGUCCAUCGAU 3682 uuAcAccucGuccAucGAudTsdT
sense 1079-1098 3683 AUCGAUGGACGAGGUGUAA 3684
AUCGAUGGACGAGGUGuAAdTsdT antis 1323-1342 3685 AUUGCACUCUGCUCUAGCC
3686 AuuGcAcucuGcucuAGccdTsdT sense 1323-1342 3687
GGCUAGAGCAGAGUGCAAU 3688 GGCuAGAGcAGAGUGcAAUdTsdT antis 1370-1389
3689 CUCCCCACUCGAGGCUUGU 3690 cuccccAcucGAGGcuuGudTsdT sense
1370-1389 3691 ACAAGCCUCGAGUGGGGAG 3692 AcAAGCCUCGAGUGGGGAGdTsdT
antis 1494-1513 3693 CCAUCUCUCAAUGCCAUUC 3694
ccAucucucAAuGccAuucdTsdT sense 1494-1513 3695 GAAUGGCAUUGAGAGAUGG
3696 GAAUGGcAUUGAGAGAUGGdTsdT antis 57-76 3697 GGGCGCUGGGCCGGAGCCG
3698 GGGcGcuGGGccGGAGccGdTsdT sense 57-76 3699 CGGCUCCGGCCCAGCGCCC
3700 CGGCUCCGGCCcAGCGCCCdTsdT antis 137-156 3701
GGCGGGGGCAGCCCAGGCA 3702 GGcGGGGGcAGcccAGGcAdTsdT sense 137-156
3703 UGCCUGGGCUGCCCCCGCC 3704 UGCCUGGGCUGCCCCCGCCdTsdT antis
141-160 3705 GGGGCAGCCCAGGCAGCCC 3706 GGGGcAGcccAGGcAGcccdTsdT
sense 141-160 3707 GGGCUGCCUGGGCUGCCCC 3708
GGGCUGCCUGGGCUGCCCCdTsdT antis 198-217 3709 GGCGGCGGGCCUUCGGGAG
3710 GGcGGcGGGccuucGGGAGdTsdT sense 198-217 3711
CUCCCGAAGGCCCGCCGCC 3712 CUCCCGAAGGCCCGCCGCCdTsdT antis 319-338
3713 CAGGAGGCACUGGCGGCGG 3714 cAGGAGGcAcuGGcGGcGGdTsdT sense
319-338 3715 CCGCCGCCAGUGCCUCCUG 3710 CCGCCGCcAGUGCCUCCUGdTsdT
antis 417-436 3717 GGCAGCGGUGGCCCCGGCG 3718
GGcAGcGGuGGccccGGcGdTsdT sense 417-436 3719 CGCCGGGGCCACCGCUGCC
3720 CGCCGGGGCcACCGCUGCCdTsdT antis 490-509 3721
UGACCACAGUGGUAGCCAC 3722 uGAccAcAGuGGuAGccAcdTsdT sense 490-509
3723 GUGGCUACCACUGUGGUCA 3724 GUGGCuACcACUGUGGUcAdTsdT antis
503-522 3725 AGCCACUGUAGGCCAAGGC 3726 AGccAcuGuAGGccAAGGcdTsdT
sense 503-522 3727 GCCUUGGCCUACAGUGGCU 3728
GCCUUGGCCuAcAGUGGCUdTsdT antis 539-558 3729 AGUGGCUUACACUGACAUC
3730 AGuGGcuuAcAcuGAcAucdTsdT sense 539-558 3731
GAUGUCAGUGUAAGCCACU 3732 GAUGUcAGUGuAAGCcACUdTsdT antis 602-621
3733 GCUGGCAGAGACGAGGGAA 3734 GcuGGcAGAGAcGAGGGAAdTsdT sense
602-621 3735 UUCCCUCGUCUCUGCCAGC 3736 UUCCCUCGUCUCUGCcAGCdTsdT
antis 793-812 3737 CGGUGUACCGAGUGGCCCG 3738
cGGuGuAccGAGuGGcccGdTsdT sense 793-812 3739 CGGGCCACUCGGUACACCG
3740 CGGGCcACUCGGuAcACCGdTsdT antis 825-844 3741
GCCAAGCUGAUCACCCCUA 3742 GccAAGcuGAucAccccuAdTsdT sense 825-844
3743 UAGGGGUGAUCAGCUUGGC 3744 uAGGGGUGAUcAGCUUGGCdTsdT antis
829-848 3745 AGCUGAUCACCCCUAUCAU 3746 AGcuGAucAccccuAucAudTsdT
sense 829-848 3747 AUGAUAGGGGUGAUCAGCU 3748
AUGAuAGGGGUGAUcAGCUdTsdT antis 843-862 3749 AUCAUCUACAUCAAGGUGU
3750 AucAucuAcAucAAGGuGudTsdT sense 843-862 3751
ACACCUUGAUGUAGAUGAU 3752 AcACCUUGAUGuAGAUGAUdTsdT antis
844-863 3753 UCAUCUACAUCAAGGUGUA 3754 ucAucuAcAucAAGGuGuAdTsdT
sense 844-863 3755 UACACCUUGAUGUAGAUGA 3756
uAcACCUUGAUGuAGAUGAdTsdT antis 888-907 3757 GCCUACAUCCACUCCCAAG
3758 GccuAcAuccAcucccAAGdTsdT sense 888-907 3759
CUUGGGAGUGGAUGUAGGC 3760 CUUGGGAGUGGAUGuAGGCdTsdT antis 902-921
3761 CCAAGGUGUGUGUCACCGU 3762 ccAAGGuGuGuGucAccGudTsdT sense
902-921 3763 ACGGUGACACACACCUUGG 3764 ACGGUGAcAcAcACCUUGGdTsdT
antis 1067-1086 3765 UGGAGCCACAGAUUACACC 3766
uGGAGccAcAGAuuAcAccdTsdT sense 1067-1086 3767 GGUGUAAUCUGUGGCUCCA
3768 GGUGuAAUCUGUGGCUCcAdTsdT antis 1095-1114 3769
GAUGUGUGGUCGGCUGGCU 3770 GAuGuGuGGucGGcuGGcudTsdT sense 1095-1114
3771 AGCCAGCCGACCACACAUC 3772 AGCcAGCCGACcAcAcAUCdTsdT antis
1154-1173 3773 UGGGGACAGUGGGGUGGAC 3774 uGGGGAcAGuGGGGuGGAcdTsdT
sense 1154-1173 3775 GUCCACCCCACUGUCCCCA 3776
GUCcACCCcACUGUCCCcAdTsdT antis 1271-1290 3777 AGCUCACCCUUGGACAAAG
3778 AGcucAcccuuGGAcAAAGdTsdT sense 1271-1290 3779
CUUUGUCCAAGGGUGAGCU 3780 CUUUGUCcAAGGGUGAGCUdTsdT antis 1272-1291
3781 GCUCACCCUUGGACAAAGG 3782 GcucAcccuuGGAcAAAGGdTsdT sense
1272-1291 3783 CCUUUGUCCAAGGGUGAGC 3784 CCUUUGUCcAAGGGUGAGCdTsdT
antis 1289-1308 3785 GGUGUUCAAAUCUUCAAAG 3786
GGuGuucAAAucuucAAAGdTsdT sense 1289-1308 3787 CUUUGAAGAUUUGAACACC
3788 CUUUGAAGAUUUGAAcACCdTsdT antis 1324-1343 3789
UUGCACUCUGCUCUAGCCU 3790 uuGcAcucuGcucuAGccudTsdT sense 1324-1343
3791 AGGCUAGAGCAGAGUGCAA 3792 AGGCuAGAGcAGAGUGcAAdTsdT antis
1351-1370 3793 ACACGCCAUCCUCAAGGCU 3794 AcAcGccAuccucAAGGcudTsdT
sense 1351-1370 3795 AGCCUUGAGGAUGGCGUGU 3796
AGCCUUGAGGAUGGCGUGUdTsdT antis 1371-1390 3797 UCCCCACUCGAGGCUUGUG
3798 uccccAcucGAGGcuuGuGdTsdT sense 1371-1390 3799
CACAAGCCUCGAGUGGGGA 3800 cAcAAGCCUCGAGUGGGGAdTsdT antis 1392-1411
3801 CACAGCUUCUUCGAUGAAC 3802 cAcAGcuucuucGAuGAAcdTsdT sense
1392-1411 3803 GUUCAUCGAAGAAGCUGUG 3804 GUUcAUCGAAGAAGCUGUGdTsdT
antis 1395-1414 3805 AGCUUCUUCGAUGAACUGC 3806
AGcuucuucGAuGAAcuGcdTsdT sense 1395-1414 3807 GCAGUUCAUCGAAGAAGCU
3808 GcAGUUcAUCGAAGAAGCUdTsdT antis 1439-1458 3809
CGACCGCCCGCUUCCCCCC 3810 cGAccGcccGcuuccccccdTsdT sense 1439-1458
3811 GGGGGGAAGCGGGCGGUCG 3812 GGGGGGAAGCGGGCGGUCGdTsdT antis
1442-1461 3813 CCGCCCGCUUCCCCCCCUG 3814 ccGcccGcuucccccccuGdTsdT
sense 1442-1461 3815 CAGGGGGGGAAGCGGGCGG 3816
cAGGGGGGGAAGCGGGCGGdTsdT antis 1467-1486 3817 UUCAGUCCUGGUGAACUGU
3818 uucAGuccuGGuGAAcuGudTsdT sense 1467-1486 3819
ACAGUUCACCAGGACUGAA 3820 AcAGUUcACcAGGACUGAAdTsdT antis 1468-1487
3821 UCAGUCCUGGUGAACUGUC 3822 ucAGuccuGGuGAAcuGucdTsdT sense
1468-1487 3823 GACAGUUCACCAGGACUGA 3824 GAcAGUUcACcAGGACUGAdTsdT
antis 1482-1501 3825 CUGUCCAUCCAACCAUCUC 3826
cuGuccAuccAAccAucucdTsdT sense 1482-1501 3827 GAGAUGGUUGGAUGGACAG
3828 GAGAUGGUUGGAUGGAcAGdTsdT antis 1483-1502 3829
UGUCCAUCCAACCAUCUCU 3830 uGuccAuccAAccAucucudTsdT sense 1483-1502
3831 AGAGAUGGUUGGAUGGACA 3832 AGAGAUGGUUGGAUGGAcAdTsdT antis
1495-1514 3833 CAUCUCUCAAUGCCAUUCU 3834 cAucucucAAuGccAuucudTsdT
sense 1495-1514 3835 AGAAUGGCAUUGAGAGAUG 3836
AGAAUGGcAUUGAGAGAUGdTsdT antis 1554-1573 3837 CCCCUCACCACUUCCUACA
3838 ccccucAccAcuuccuAcAdTsdT sense 1554-1573 3839
UGUAGGAAGUGGUGAGGGG 3840 UGuAGGAAGUGGUGAGGGGdTsdT antis 1597-1616
3841 AAGCUCAGACUGGCCAAGA 3842 AAGcucAGAcuGGccAAGAdTsdT sense
1597-1616 3843 UCUUGGCCAGUCUGAGCUU 3844 UCUUGGCcAGUCUGAGCUUdTsdT
antis 1659-1678 3845 UCCUGAGGGCCCCACCGAC 3846
uccuGAGGGccccAccGAcdTsdT sense 1659-1678 3847 GUCGGUGGGGCCCUCAGGA
3848 GUCGGUGGGGCCCUcAGGAdTsdT antis 1814-1833 3849
CAGCAGCCUAACCUCUGUG 3850 cAGcAGccuAAccucuGuGdTsdT sense 1814-1833
3851 CACAGAGGUUAGGCUGCUG 3852 cAcAGAGGUuAGGCUGCUGdTsdT antis
1815-1834 3853 AGCAGCCUAACCUCUGUGG 3854 AGcAGccuAAccucuGuGGdTsdT
sense 1815-1834 3855 CCACAGAGGUUAGGCUGCU 3856
CcAcAGAGGUuAGGCUGCUdTsdT antis 1904-1923 3857 UGAGGACCUUCUACCCCCU
3858 uGAGGAccuucuAcccccudTsdT sense 1904-1923 3859
AGGGGGUAGAAGGUCCUCA 3860 AGGGGGuAGAAGGUCCUcAdTsdT antis 1905-1924
3861 GAGGACCUUCUACCCCCUU 3862 GAGGAccuucuAcccccuudTsdT sense
1905-1924 3863 AAGGGGGUAGAAGGUCCUC 3864 AAGGGGGuAGAAGGUCCUCdTsdT
antis 2012-2031 3865 GUCUUCCCUUCCCUGGCCC 3866
GucuucccuucccuGGcccdTsdT sense 2012-2031 3867 GGGCCAGGGAAGGGAAGAC
3868 GGGCcAGGGAAGGGAAGACdTsdT antis 2095-2114 3869
UGCCCCCCCCAGCUGUACC 3870 uGccccccccAGcuGuAccdTsdT sense 2095-2114
3871 GGUACAGCUGGGGGGGGCA 3872 GGuAcAGCUGGGGGGGGcAdTsdT antis
2102-2121 3873 CCCAGCUGUACCCCUUCUU 3874 cccAGcuGuAccccuucuudTsdT
sense 2102-2121 3875 AAGAAGGGGUACAGCUGGG 3876
AAGAAGGGGuAcAGCUGGGdTsdT antis 2184-2203 3877 CUGGUGUCUUAGUUUCCAC
3878 cuGGuGucuuAGuuuccAcdTsdT sense 2184-2203 3879
GUGGAAACUAAGACACCAG 3880 GUGGAAACuAAGAcACcAGdTsdT antis 2192-2211
3881 UUAGUUUCCACAGUAAGGU 3882 uuAGuuuccAcAGuAAGGudTsdT sense
2192-2211 3883 ACCUUACUGUGGAAACUAA 3884 ACCUuACUGUGGAAACuAAdTsdT
antis 2227-2246 3885 CUCUGUUCAAUAAAUUAUU 3886
cucuGuucAAuAAAuuAuudTsdT sense 2227-2246 3887 AAUAAUUUAUUGAACAGAG
3888 AAuAAUUuAUUGAAcAGAGdTsdT antis 151-170 3889
AGGCAGCCCGAGCCCCGCG 3890 AGGcAGcccGAGccccGcGdTsdT sense 151-170
3891 CGCGGGGCUCGGGCUGCCU 3892 CGCGGGGCUCGGGCUGCCUdTsdT antis
404-423 3893 CAGCGGCGGAGGAGGCAGC 3894 cAGcGGcGGAGGAGGcAGcdTsdT
sense 404-423 3895 GCUGCCUCCUCCGCCGCUG 3896
GCUGCCUCCUCCGCCGCUGdTsdT antis 530-549 3897 UUCCCAAGAAGUGGCUUAC
3898 uucccAAGAAGuGGcuuAcdTsdT sense 530-549 3899
GUAAGCCACUUCUUGGGAA 3900 GuAAGCcACUUCUUGGGAAdTsdT antis 954-973
3901 GACACUGCUGUCCUCAAGC 3902 GAcAcuGcuGuccucAAGcdTsdT sense
954-973 3903 GCUUGAGGACAGCAGUGUC 3904 GCUUGAGGAcAGcAGUGUCdTsdT
antis 1394-1413 3905 CAGCUUCUUCGAUGAACUG 3906
cAGcuucuucGAuGAAcuGdTsdT sense 1394-1413 3907 CAGUUCAUCGAAGAAGCUG
3908 cAGUUcAUCGAAGAAGCUGdTsdT antis 2002-2021 3909
CCCAUCUCUCGUCUUCCCU 3910 cccAucucucGucuucccudTsdT sense 2002-2021
3911 AGGGAAGACGAGAGAUGGG 3912 AGGGAAGACGAGAGAUGGGdTsdT antis
2003-2022 3913 CCAUCUCUCGUCUUCCCUU 3914 ccAucucucGucuucccuudTsdT
sense 2003-2022 3915 AAGGGAAGACGAGAGAUGG 3916
AAGGGAAGACGAGAGAUGGdTsdT antis 2121-2140 3917 GUCCUCUGCUCCCAAGGCU
3918 GuccucuGcucccAAGGcudTsdT sense 2121-2140 3919
AGCCUUGGGAGCAGAGGAC 3920 AGCCUUGGGAGcAGAGGACdTsdT antis 24-43 3921
AGAGGGACUUCAUCUCCCG 3922 AGAGGGAcuucAucucccGdTsdT sense 24-43 3923
CGGGAGAUGAAGUCCCUCU 3924 CGGGAGAUGAAGUCCCUCUdTsdT antis 49-68 3925
CCCGCGGCGGGCGCUGGGC 3926 cccGcGGcGGGcGcuGGGcdTsdT sense 49-68 3927
GCCCAGCGCCCGCCGCGGG 3928 GCCcAGCGCCCGCCGCGGGdTsdT antis 107-126
3929 GAGCCCAGGGGAGGCGGCG 3930 GAGcccAGGGGAGGcGGcGdTsdT sense
107-126 3931 CGCCGCCUCCCCUGGGCUC 3932 CGCCGCCUCCCCUGGGCUCdTsdT
antis 126-145 3933 GCAGAGGCAGCGGCGGGGG 3934
GcAGAGGcAGcGGcGGGGGdTsdT sense 126-145 3935 CCCCCGCCGCUGCCUCUGC
3936 CCCCCGCCGCUGCCUCUGCdTsdT antis 153-172 3937
GCAGCCCGAGCCCCGCGGC 3938 GcAGcccGAGccccGcGGcdTsdT sense 153-172
3939 GCCGCGGGGCUCGGGCUGC 3940 GCCGCGGGGCUCGGGCUGCdTsdT antis
259-278 3941 CGGAGCCAGGAGGCGGAGG 3942 cGGAGccAGGAGGcGGAGGdTsdT
sense 259-278 3943 CCUCCGCCUCCUGGCUCCG 3944
CCUCCGCCUCCUGGCUCCGdTsdT antis 261-280 3945 GAGCCAGGAGGCGGAGGCG
3946 GAGccAGGAGGcGGAGGcGdTsdT sense 261-280 3947
CGCCUCCGCCUCCUGGCUC 3948 CGCCUCCGCCUCCUGGCUCdTsdT antis 512-531
3949 AGGCCAAGGCCCAGAGCGU 3950 AGGccAAGGcccAGAGcGudTsdT sense
512-531 3951 ACGCUCUGGGCCUUGGCCU 3952 ACGCUCUGGGCCUUGGCCUdTsdT
antis 660-679 3953 AAGAACCGAGAACUGCAGA 3954
AAGAAccGAGAAcuGcAGAdTsdT sense 660-679 3955 UCUGCAGUUCUCGGUUCUU
3956 UCUGcAGUUCUCGGUUCUUdTsdT antis 709-728 3957
UGAGGCUGCGGUACUUUUU 3958 uGAGGcuGcGGuAcuuuuudTsdT sense 709-728
3959 AAAAAGUACCGCAGCCUCA 3960 AAAAAGuACCGcAGCCUcAdTsdT antis
710-729 3961 GAGGCUGCGGUACUUUUUC 3962 GAGGcuGcGGuAcuuuuucdTsdT
sense 710-729 3963 GAAAAAGUACCGCAGCCUC 3964
GAAAAAGuACCGcAGCCUCdTsdT antis 792-811 3965 ACGGUGUACCGAGUGGCCC
3966 AcGGuGuAccGAGuGGcccdTsdT sense 792-811 3967
GGGCCACUCGGUACACCGU 3968 GGGCcACUCGGuAcACCGUdTsdT antis 903-922
3969 CAAGGUGUGUGUCACCGUG 3970 cAAGGuGuGuGucAccGuGdTsdT sense
903-922 3971 CACGGUGACACACACCUUG 3972 cACGGUGAcAcAcACCUUGdTsdT
antis 1110-1129 3973 GGCUGUGUACUUGCUGAGC 3974
GGcuGuGuAcuuGcuGAGcdTsdT sense 1110-1129 3975 GCUCAGCAAGUACACAGCC
3976 GCUcAGcAAGuAcAcAGCCdTsdT antis 1129-1148 3977
UACUUCUCGGCCAGCCCAU 3978 uAcuucucGGccAGcccAudTsdT sense 1129-1148
3979 AUGGGCUGGCCGAGAAGUA 3980 AUGGGCUGGCCGAGAAGuAdTsdT antis
1142-1161 3981 GCCCAUCUUCCCUGGGGAC 3982 GcccAucuucccuGGGGAcdTsdT
sense 1142-1161 3983 GUCCCCAGGGAAGAUGGGC 3984
GUCCCcAGGGAAGAUGGGCdTsdT antis 1153-1172 3985 CUGGGGACAGUGGGGUGGA
3986 cuGGGGAcAGuGGGGuGGAdTsdT sense 1153-1172 3987
UCCACCCCACUGUCCCCAG 3988 UCcACCCcACUGUCCCcAGdTsdT antis 1472-1491
3989 UCCUGGUGAACUGUCCAUC 3990 uccuGGuGAAcuGuccAucdTsdT sense
1472-1491 3991 GAUGGACAGUUCACCAGGA 3992 GAUGGAcAGUUcACcAGGAdTsdT
antis 1473-1492 3993 CCUGGUGAACUGUCCAUCC 3994
ccuGGuGAAcuGuccAuccdTsdT sense 1473-1492 3995 GGAUGGACAGUUCACCAGG
3996 GGAUGGAcAGUUcACcAGGdTsdT antis 1652-1671 3997
UAGCUCUUCCUGAGGGCCC 3998 uAGcucuuccuGAGGGcccdTsdT sense 1652-1671
3999 GGGCCCUCAGGAAGAGCUA 4000 GGGCCCUcAGGAAGAGCuAdTsdT antis
1653-1672 4001 AGCUCUUCCUGAGGGCCCC 4002 AGcucuuccuGAGGGccccdTsdT
sense 1653-1672 4003 GGGGCCCUCAGGAAGAGCU 4004
GGGGCCCUcAGGAAGAGCUdTsdT antis
1812-1831 4005 CUCAGCAGCCUAACCUCUG 4006 cucAGcAGccuAAccucuGdTsdT
sense 1812-1831 4007 CAGAGGUUAGGCUGCUGAG 4008
cAGAGGUuAGGCUGCUGAGdTsdT antis 1952-1971 4009 UCCUUCCCUCCCCCCCUCU
4010 uccuucccucccccccucudTsdT sense 1952-1971 4011
AGAGGGGGGGAGGGAAGGA 4012 AGAGGGGGGGAGGGAAGGAdTsdT antis 1968-1987
4013 UCUCCCAGGUCCCUUGUAA 4014 ucucccAGGucccuuGuAAdTsdT sense
1968-1987 4015 UUACAAGGGACCUGGGAGA 4016 UuAcAAGGGACCUGGGAGAdTsdT
antis 2051-2070 4017 UAUAAUUUUUUCUUAAAGA 4018
uAuAAuuuuuucuuAAAGAdTsdT sense 2051-2070 4019 UCUUUAAGAAAAAAUUAUA
4020 UCUUuAAGAAAAAAUuAuAdTsdT antis 2056-2075 4021
UUUUUUCUUAAAGAAAACG 4022 uuuuuucuuAAAGAAAAcGdTsdT sense 2056-2075
4023 CGUUUUCUUUAAGAAAAAA 4024 CGUUUUCUUuAAGAAAAAAdTsdT antis
2128-2147 4025 GCUCCCAAGGCUUCCUCCC 4026 GcucccAAGGcuuccucccdTsdT
sense 2128-2147 4027 GGGAGGAAGCCUUGGGAGC 4028
GGGAGGAAGCCUUGGGAGCdTsdT antis 2135-2154 4029 AGGCUUCCUCCCUCUCCCC
4030 AGGcuuccucccucuccccdTsdT sense 2135-2154 4031
GGGGAGAGGGAGGAAGCCU 4032 GGGGAGAGGGAGGAAGCCUdTsdT antis 2136-2155
4033 GGCUUCCUCCCUCUCCCCA 4034 GGcuuccucccucuccccAdTsdT sense
2136-2155 4035 UGGGGAGAGGGAGGAAGCC 4036 UGGGGAGAGGGAGGAAGCCdTsdT
antis 2147-2166 4037 UCUCCCCAUCCUGGAAGGA 4038
ucuccccAuccuGGAAGGAdTsdT sense 2147-2166 4039 UCCUUCCAGGAUGGGGAGA
4040 UCCUUCcAGGAUGGGGAGAdTsdT antis 511-530 4041
UAGGCCAAGGCCCAGAGCG 4042 uAGGccAAGGcccAGAGcGdTsdT sense 511-530
4043 CGCUCUGGGCCUUGGCCUA 4044 CGCUCUGGGCCUUGGCCuAdTsdT antis
677-696 4045 GAUUAUGCGUAAGCUGGAC 4046 GAuuAuGcGuAAGcuGGAcdTsdT
sense 677-696 4047 GUCCAGCUUACGCAUAAUC 4048
GUCcAGCUuACGcAuAAUCdTsdT antis 682-701 4049 UGCGUAAGCUGGACCACUG
4050 uGcGuAAGcuGGAccAcuGdTsdT sense 682-701 4051
CAGUGGUCCAGCUUACGCA 4052 cAGUGGUCcAGCUuACGcAdTsdT antis 796-815
4053 UGUACCGAGUGGCCCGCCA 4054 uGuAccGAGuGGcccGccAdTsdT sense
796-815 4055 UGGCGGGCCACUCGGUACA 4056 UGGCGGGCcACUCGGuAcAdTsdT
antis 750-769 4057 GACGAGCUGUAUUUGAAUC 4058
GAcGAGcuGuAuuuGAAucdTsdT sense 750-769 4059 GAUUCAAAUACAGCUCGUC
4060 GAUUcAAAuAcAGCUCGUCdTsdT antis 1646-1665 4061
CCUCGCUAGCUCUUCCUGA 4062 ccucGcuAGcucuuccuGAdTsdT sense 1646-1665
4063 UCAGGAAGAGCUAGCGAGG 4064 UcAGGAAGAGCuAGCGAGGdTsdT antis
664-683 4065 ACCGAGAACUGCAGAUUAU 4066 AccGAGAAcuGcAGAuuAudTsdT
sense 664-683 4067 AUAAUCUGCAGUUCUCGGU 4068
AuAAUCUGcAGUUCUCGGUdTsdT antis 751-770 4069 ACGAGCUGUAUUUGAAUCU
4070 AcGAGcuGuAuuuGAAucudTsdT sense 751-770 4071
AGAUUCAAAUACAGCUCGU 4072 AGAUUcAAAuAcAGCUCGUdTsdT antis 835-854
4073 UCACCCCUAUCAUCUACAU 4074 ucAccccuAucAucuAcAudTsdT sense
835-854 4075 AUGUAGAUGAUAGGGGUGA 4076 AUGuAGAUGAuAGGGGUGAdTsdT
antis 1399-1418 4077 UCUUCGAUGAACUGCGGAG 4078
ucuucGAuGAAcuGcGGAGdTsdT sense 1399-1418 4079 CUCCGCAGUUCAUCGAAGA
4080 CUCCGcAGUUcAUCGAAGAdTsdT antis 2175-2194 4081
AGAGAGUCCCUGGUGUCUU 4082 AGAGAGucccuGGuGucuudTsdT sense 2175-2194
4083 AAGACACCAGGGACUCUCU 4084 AAGAcACcAGGGACUCUCUdTsdT antis 19-38
4085 ACGGCAGAGGGACUUCAUC 4086 AcGGcAGAGGGAcuucAucdTsdT sense 19-38
4087 GAUGAAGUCCCUCUGCCGU 4088 GAUGAAGUCCCUCUGCCGUdTsdT antis 79-98
4089 CCCGAACGGCGCGGCCUGG 4090 cccGAAcGGcGcGGccuGGdTsdT sense 79-98
4091 CCAGGCCGCGCCGUUCGGG 4092 CcAGGCCGCGCCGUUCGGGdTsdT antis
186-205 4093 GGCGCCAUGAGCGGCGGCG 4094 GGcGccAuGAGcGGcGGcGdTsdT
sense 186-205 4095 CGCCGCCGCUCAUGGCGCC 4096
CGCCGCCGCUcAUGGCGCCdTsdT antis 187-206 4097 GCGCCAUGAGCGGCGGCGG
4098 GcGccAuGAGcGGcGGcGGdTsdT sense 187-206 4099
CCGCCGCCGCUCAUGGCGC 4100 CCGCCGCCGCUcAUGGCGCdTsdT antis 334-353
4101 GCGGGAAAGCGUCAGUCGG 4102 GcGGGAAAGcGucAGucGGdTsdT sense
334-353 4103 CCGACUGACGCUUUCCCGC 4104 CCGACUGACGCUUUCCCGCdTsdT
antis 349-368 4105 UCGGGGCUAUGGGUGGGGG 4106
ucGGGGcuAuGGGuGGGGGdTsdT sense 349-368 4107 CCCCCACCCAUAGCCCCGA
4108 CCCCcACCcAuAGCCCCGAdTsdT antis 451-470 4109
CGCCGCCGGGAGUGAAGCU 4110 cGccGccGGGAGuGAAGcudTsdT sense 451-470
4111 AGCUUCACUCCCGGCGGCG 4112 AGCUUcACUCCCGGCGGCGdTsdT antis
476-495 4113 UGACAGCGGGAAGGUGACC 4114 uGAcAGcGGGAAGGuGAccdTsdT
sense 476-495 4115 GGUCACCUUCCCGCUGUCA 4116
GGUcACCUUCCCGCUGUcAdTsdT antis 480-499 4117 AGCGGGAAGGUGACCACAG
4118 AGcGGGAAGGuGAccAcAGdTsdT sense 480-499 4119
CUGUGGUCACCUUCCCGCU 4120 CUGUGGUcACCUUCCCGCUdTsdT antis 481-500
4121 GCGGGAAGGUGACCACAGU 4122 GcGGGAAGGuGAccAcAGudTsdT sense
481-500 4123 ACUGUGGUCACCUUCCCGC 4124 ACUGUGGUcACCUUCCCGCdTsdT
antis 516-535 4125 CAAGGCCCAGAGCGUUCCC 4126
cAAGGcccAGAGcGuucccdTsdT sense 516-535 4127 GGGAACGCUCUGGGCCUUG
4128 GGGAACGCUCUGGGCCUUGdTsdT antis 586-605 4129
UAGUAUACCAGGCACGGCU 4130 uAGuAuAccAGGcAcGGcudTsdT sense 586-605
4131 AGCCGUGCCUGGUAUACUA 4132 AGCCGUGCCUGGuAuACuAdTsdT antis
608-627 4133 AGAGACGAGGGAACUGGUG 4134 AGAGAcGAGGGAAcuGGuGdTsdT
sense 608-627 4135 CACCAGUUCCCUCGUCUCU 4136
cACcAGUUCCCUCGUCUCUdTsdT antis 662-681 4137 GAACCGAGAACUGCAGAUU
4138 GAAccGAGAAcuGcAGAuudTsdT sense 662-681 4139
AAUCUGCAGUUCUCGGUUC 4140 AAUCUGcAGUUCUCGGUUCdTsdT antis 678-697
4141 AUUAUGCGUAAGCUGGACC 4142 AuuAuGcGuAAGcuGGAccdTsdT sense
678-697 4143 GGUCCAGCUUACGCAUAAU 4144 GGUCcAGCUuACGcAuAAUdTsdT
antis 679-698 4145 UUAUGCGUAAGCUGGACCA 4146
uuAuGcGuAAGcuGGAccAdTsdT sense 679-698 4147 UGGUCCAGCUUACGCAUAA
4148 UGGUCcAGCUuACGcAuAAdTsdT antis 680-699 4149
UAUGCGUAAGCUGGACCAC 4150 uAuGcGuAAGcuGGAccAcdTsdT sense 680-699
4151 GUGGUCCAGCUUACGCAUA 4152 GUGGUCcAGCUuACGcAuAdTsdT antis
683-702 4153 GCGUAAGCUGGACCACUGC 4154 GcGuAAGcuGGAccAcuGcdTsdT
sense 683-702 4155 GCAGUGGUCCAGCUUACGC 4156
GcAGUGGUCcAGCUuACGCdTsdT antis 714-733 4157 CUGCGGUACUUUUUCUACU
4158 cuGcGGuAcuuuuucuAcudTsdT sense 714-733 4159
AGUAGAAAAAGUACCGCAG 4160 AGuAGAAAAAGuACCGcAGdTsdT antis 715-734
4161 UGCGGUACUUUUUCUACUC 4162 uGcGGuAcuuuuucuAcucdTsdT sense
715-734 4163 GAGUAGAAAAAGUACCGCA 4164 GAGuAGAAAAAGuACCGcAdTsdT
antis 754-773 4165 AGCUGUAUUUGAAUCUGGU 4166
AGcuGuAuuuGAAucuGGudTsdT sense 754-773 4167 ACCAGAUUCAAAUACAGCU
4168 ACcAGAUUcAAAuAcAGCUdTsdT antis 795-814 4169
GUGUACCGAGUGGCCCGCC 4170 GuGuAccGAGuGGcccGccdTsdT sense 795-814
4171 GGCGGGCCACUCGGUACAC 4172 GGCGGGCcACUCGGuAcACdTsdT antis
797-816 4173 GUACCGAGUGGCCCGCCAC 4174 GuAccGAGuGGcccGccAcdTsdT
sense 797-816 4175 GUGGCGGGCCACUCGGUAC 4176
GUGGCGGGCcACUCGGuACdTsdT antis 799-818 4177 ACCGAGUGGCCCGCCACUU
4178 AccGAGuGGcccGccAcuudTsdT sense 799-818 4179
AAGUGGCGGGCCACUCGGU 4180 AAGUGGCGGGCcACUCGGUdTsdT antis 800-819
4181 CCGAGUGGCCCGCCACUUC 4182 ccGAGuGGcccGccAcuucdTsdT sense
800-819 4183 GAAGUGGCGGGCCACUCGG 4184 GAAGUGGCGGGCcACUCGGdTsdT
antis 834-853 4185 AUCACCCCUAUCAUCUACA 4186
AucAccccuAucAucuAcAdTsdT sense 834-853 4187 UGUAGAUGAUAGGGGUGAU
4188 UGuAGAUGAuAGGGGUGAUdTsdT antis 845-864 4189
CAUCUACAUCAAGGUGUAC 4190 cAucuAcAucAAGGuGuAcdTsdT sense 845-864
4191 GUACACCUUGAUGUAGAUG 4192 GuAcACCUUGAUGuAGAUGdTsdT antis
850-869 4193 ACAUCAAGGUGUACAUGUA 4194 AcAucAAGGuGuAcAuGuAdTsdT
sense 850-869 4195 UACAUGUACACCUUGAUGU 4196
uAcAUGuAcACCUUGAUGUdTsdT antis 885-904 4197 UUGGCCUACAUCCACUCCC
4198 uuGGccuAcAuccAcucccdTsdT sense 885-904 4199
GGGAGUGGAUGUAGGCCAA 4200 GGGAGUGGAUGuAGGCcAAdTsdT antis 890-909
4201 CUACAUCCACUCCCAAGGU 4202 cuAcAuccAcucccAAGGudTsdT sense
890-909 4203 ACCUUGGGAGUGGAUGUAG 4204 ACCUUGGGAGUGGAUGuAGdTsdT
antis 921-940 4205 GACAUCAAGCCCCAGAAUU 4206
GAcAucAAGccccAGAAuudTsdT sense 921-940 4207 AAUUCUGGGGCUUGAUGUC
4208 AAUUCUGGGGCUUGAUGUCdTsdT antis 934-953 4209
AGAAUUUGCUUGUGGACCC 4210 AGAAuuuGcuuGuGGAcccdTsdT sense 934-953
4211 GGGUCCACAAGCAAAUUCU 4212 GGGUCcAcAAGcAAAUUCUdTsdT antis
1032-1051 4213 UGCUCUCGGUACUACCGUG 4214 uGcucucGGuAcuAccGuGdTsdT
sense 1032-1051 4215 CACGGUAGUACCGAGAGCA 4216
cACGGuAGuACCGAGAGcAdTsdT antis 1033-1052 4217 GCUCUCGGUACUACCGUGC
4218 GcucucGGuAcuAccGuGcdTsdT sense 1033-1052 4219
GCACGGUAGUACCGAGAGC 4220 GcACGGuAGuACCGAGAGCdTsdT antis 1081-1100
4221 ACACCUCGUCCAUCGAUGU 4222 AcAccucGuccAucGAuGudTsdT sense
1081-1100 4223 ACAUCGAUGGACGAGGUGU 4224 AcAUCGAUGGACGAGGUGUdTsdT
antis 1082-1101 4225 CACCUCGUCCAUCGAUGUG 4226
cAccucGuccAucGAuGuGdTsdT sense 1082-1101 4227 CACAUCGAUGGACGAGGUG
4228 cAcAUCGAUGGACGAGGUGdTsdT antis 1083-1102 4229
ACCUCGUCCAUCGAUGUGU 4230 AccucGuccAucGAuGuGudTsdT sense 1083-1102
4231 ACACAUCGAUGGACGAGGU 4232 AcAcAUCGAUGGACGAGGUdTsdT antis
1241-1260 4233 CUAUACGGAGUUCAAGUUC 4234 cuAuAcGGAGuucAAGuucdTsdT
sense 1241-1260 4235 GAACUUGAACUCCGUAUAG 4236
GAACUUGAACUCCGuAuAGdTsdT antis 1242-1261 4237 UAUACGGAGUUCAAGUUCC
4238 uAuAcGGAGuucAAGuuccdTsdT sense 1242-1261 4239
GGAACUUGAACUCCGUAUA 4240 GGAACUUGAACUCCGuAuAdTsdT antis 1243-1262
4241 AUACGGAGUUCAAGUUCCC 4242 AuAcGGAGuucAAGuucccdTsdT sense
1243-1262 4243 GGGAACUUGAACUCCGUAU 4244 GGGAACUUGAACUCCGuAUdTsdT
antis 1396-1415 4245 GCUUCUUCGAUGAACUGCG 4246
GcuucuucGAuGAAcuGcGdTsdT sense 1396-1415 4247 CGCAGUUCAUCGAAGAAGC
4248 CGcAGUUcAUCGAAGAAGCdTsdT antis 1397-1416 4249
CUUCUUCGAUGAACUGCGG 4250 cuucuucGAuGAAcuGcGGdTsdT sense 1397-1416
4251 CCGCAGUUCAUCGAAGAAG 4252 CCGcAGUUcAUCGAAGAAGdTsdT antis
1398-1417 4253 UUCUUCGAUGAACUGCGGA 4254 uucuucGAuGAAcuGcGGAdTsdT
sense
1398-1417 4255 UCCGCAGUUCAUCGAAGAA 4256 UCCGcAGUUcAUCGAAGAAdTsdT
antis 1400-1419 4257 CUUCGAUGAACUGCGGAGA 4258
cuucGAuGAAcuGcGGAGAdTsdT sense 1400-1419 4259 UCUCCGCAGUUCAUCGAAG
4260 UCUCCGcAGUUcAUCGAAGdTsdT antis 1452-1471 4261
CCCCCCCUGUUCAACUUCA 4262 cccccccuGuucAAcuucAdTsdT sense 1452-1471
4263 UGAAGUUGAACAGGGGGGG 4264 UGAAGUUGAAcAGGGGGGGdTsdT antis
1576-1595 4265 CAUCCUCACAAGCUUUAAC 4266 cAuccucAcAAGcuuuAAcdTsdT
sense 1576-1595 4267 GUUAAAGCUUGUGAGGAUG 4268
GUuAAAGCUUGUGAGGAUGdTsdT antis 1634-1653 4269 CACAACUGCUACCCUCGCU
4270 cAcAAcuGcuAcccucGcudTsdT sense 1634-1653 4271
AGCGAGGGUAGCAGUUGUG 4272 AGCGAGGGuAGcAGUUGUGdTsdT antis 1635-1654
4273 ACAACUGCUACCCUCGCUA 4274 AcAAcuGcuAcccucGcuAdTsdT sense
1635-1654 4275 UAGCGAGGGUAGCAGUUGU 4276 uAGCGAGGGuAGcAGUUGUdTsdT
antis 1643-1662 4277 UACCCUCGCUAGCUCUUCC 4278
uAcccucGcuAGcucuuccdTsdT sense 1643-1662 4279 GGAAGAGCUAGCGAGGGUA
4280 GGAAGAGCuAGCGAGGGuAdTsdT antis 1645-1664 4281
CCCUCGCUAGCUCUUCCUG 4282 cccucGcuAGcucuuccuGdTsdT sense 1645-1664
4283 CAGGAAGAGCUAGCGAGGG 4284 cAGGAAGAGCuAGCGAGGGdTsdT antis
1660-1679 4285 CCUGAGGGCCCCACCGACU 4286 ccuGAGGGccccAccGAcudTsdT
sense 1660-1679 4287 AGUCGGUGGGGCCCUCAGG 4288
AGUCGGUGGGGCCCUcAGGdTsdT antis 1664-1683 4289 AGGGCCCCACCGACUACCC
4290 AGGGccccAccGAcuAcccdTsdT sense 1664-1683 4291
GGGUAGUCGGUGGGGCCCU 4292 GGGuAGUCGGUGGGGCCCUdTsdT antis 1665-1684
4293 GGGCCCCACCGACUACCCC 4294 GGGccccAccGAcuAccccdTsdT sense
1665-1684 4295 GGGGUAGUCGGUGGGGCCC 4296 GGGGuAGUCGGUGGGGCCCdTsdT
antis 1816-1835 4297 GCAGCCUAACCUCUGUGGU 4298
GcAGccuAAccucuGuGGudTsdT sense 1816-1835 4299 ACCACAGAGGUUAGGCUGC
4300 ACcAcAGAGGUuAGGCUGCdTsdT antis 1817-1836 4301
CAGCCUAACCUCUGUGGUG 4302 cAGccuAAccucuGuGGuGdTsdT sense 1817-1836
4303 CACCACAGAGGUUAGGCUG 4304 cACcAcAGAGGUuAGGCUGdTsdT antis
1973-1992 4305 CAGGUCCCUUGUAAAUAGA 4306 cAGGucccuuGuAAAuAGAdTsdT
sense 1973-1992 4307 UCUAUUUACAAGGGACCUG 4308
UCuAUUuAcAAGGGACCUGdTsdT antis 2206-2225 4309 AAGGUUUGCCUGUGUACAG
4310 AAGGuuuGccuGuGuAcAGdTsdT sense 2206-2225 4311
CUGUACACAGGCAAACCUU 4312 CUGuAcAcAGGcAAACCUUdTsdT antis 2207-2226
4313 AGGUUUGCCUGUGUACAGA 4314 AGGuuuGccuGuGuAcAGAdTsdT sense
2207-2226 4315 UCUGUACACAGGCAAACCU 4316 UCUGuAcAcAGGcAAACCUdTsdT
antis 2222-2241 4317 CAGACCUCUGUUCAAUAAA 4318
cAGAccucuGuucAAuAAAdTsdT sense 2222-2241 4319 UUUAUUGAACAGAGGUCUG
4320 UUuAUUGAAcAGAGGUCUGdTsdT antis 542-561 4321
GGCUUACACUGACAUCAAA 4322 GGcuuAcAcuGAcAucAAAdTsdT sense 542-561
4323 UUUGAUGUCAGUGUAAGCC 4324 UUUGAUGUcAGUGuAAGCCdTsdT antis
681-700 4325 AUGCGUAAGCUGGACCACU 4326 AuGcGuAAGcuGGAccAcudTsdT
sense 681-700 4327 AGUGGUCCAGCUUACGCAU 4328
AGUGGUCcAGCUuACGcAUdTsdT antis 748-767 4329 AGGACGAGCUGUAUUUGAA
4330 AGGAcGAGcuGuAuuuGAAdTsdT sense 748-767 4331
UUCAAAUACAGCUCGUCCU 4332 UUcAAAuAcAGCUCGUCCUdTsdT antis 749-768
4333 GGACGAGCUGUAUUUGAAU 4334 GGAcGAGcuGuAuuuGAAudTsdT sense
749-768 4335 AUUCAAAUACAGCUCGUCC 4336 AUUcAAAuAcAGCUCGUCCdTsdT
antis 1352-1371 4337 CACGCCAUCCUCAAGGCUC 4338
cAcGccAuccucAAGGcucdTsdT sense 1352-1371 4339 GAGCCUUGAGGAUGGCGUG
4340 GAGCCUUGAGGAUGGCGUGdTsdT antis 1944-1963 4341
GCUACCACUCCUUCCCUCC 4342 GcuAccAcuccuucccuccdTsdT sense 1944-1963
4343 GGAGGGAAGGAGUGGUAGC 4344 GGAGGGAAGGAGUGGuAGCdTsdT antis
2004-2023 4345 CAUCUCUCGUCUUCCCUUC 4346 cAucucucGucuucccuucdTsdT
sense 2004-2023 4347 GAAGGGAAGACGAGAGAUG 4348
GAAGGGAAGACGAGAGAUGdTsdT antis 348-367 4349 GUCGGGGCUAUGGGUGGGG
4350 GucGGGGcuAuGGGuGGGGdTsdT sense 348-367 4351
CCCCACCCAUAGCCCCGAC 4352 CCCcACCcAuAGCCCCGACdTsdT antis 39-58 4353
CCCGGCGUGCCCCGCGGCG 4354 cccGGcGuGccccGcGGcGdTsdT sense 39-58 4355
CGCCGCGGGGCACGCCGGG 4356 CGCCGCGGGGcACGCCGGGdTsdT antis 184-203
4357 UCGGCGCCAUGAGCGGCGG 4358 ucGGcGccAuGAGcGGcGGdTsdT sense
184-203 4359 CCGCCGCUCAUGGCGCCGA 4360 CCGCCGCUcAUGGCGCCGAdTsdT
antis 344-363 4361 GUCAGUCGGGGCUAUGGGU 4362
GucAGucGGGGcuAuGGGudTsdT sense 344-363 4363 ACCCAUAGCCCCGACUGAC
4364 ACCcAuAGCCCCGACUGACdTsdT antis 347-366 4365
AGUCGGGGCUAUGGGUGGG 4366 AGucGGGGcuAuGGGuGGGdTsdT sense 347-366
4367 CCCACCCAUAGCCCCGACU 4368 CCcACCcAuAGCCCCGACUdTsdT antis
454-473 4369 CGCCGGGAGUGAAGCUGGG 4370 cGccGGGAGuGAAGcuGGGdTsdT
sense 454-473 4371 CCCAGCUUCACUCCCGGCG 4372
CCcAGCUUcACUCCCGGCGdTsdT antis 456-475 4373 CCGGGAGUGAAGCUGGGCC
4374 ccGGGAGuGAAGcuGGGccdTsdT sense 456-475 4375
GGCCCAGCUUCACUCCCGG 4376 GGCCcAGCUUcACUCCCGGdTsdT antis 477-496
4377 GACAGCGGGAAGGUGACCA 4378 GAcAGcGGGAAGGuGAccAdTsdT sense
477-496 4379 UGGUCACCUUCCCGCUGUC 4380 UGGUcACCUUCCCGCUGUCdTsdT
antis 479-498 4381 CAGCGGGAAGGUGACCACA 4382
cAGcGGGAAGGuGAccAcAdTsdT sense 479-498 4383 UGUGGUCACCUUCCCGCUG
4384 UGUGGUcACCUUCCCGCUGdTsdT antis 517-536 4385
AAGGCCCAGAGCGUUCCCA 4386 AAGGcccAGAGcGuucccAdTsdT sense 517-536
4387 UGGGAACGCUCUGGGCCUU 4388 UGGGAACGCUCUGGGCCUUdTsdT antis
518-537 4389 AGGCCCAGAGCGUUCCCAA 4390 AGGcccAGAGcGuucccAAdTsdT
sense 518-537 4391 UUGGGAACGCUCUGGGCCU 4392
UUGGGAACGCUCUGGGCCUdTsdT antis 519-538 4393 GGCCCAGAGCGUUCCCAAG
4394 GGcccAGAGcGuucccAAGdTsdT sense 519-538 4395
CUUGGGAACGCUCUGGGCC 4396 CUUGGGAACGCUCUGGGCCdTsdT antis 544-563
4397 CUUACACUGACAUCAAAGU 4398 cuuAcAcuGAcAucAAAGudTsdT sense
544-563 4399 ACUUUGAUGUCAGUGUAAG 4400 ACUUUGAUGUcAGUGuAAGdTsdT
antis 545-564 4401 UUACACUGACAUCAAAGUG 4402
uuAcAcuGAcAucAAAGuGdTsdT sense 545-564 4403 CACUUUGAUGUCAGUGUAA
4404 cACUUUGAUGUcAGUGuAAdTsdT antis 603-622 4405
CUGGCAGAGACGAGGGAAC 4406 cuGGcAGAGAcGAGGGAAcdTsdT sense 603-622
4407 GUUCCCUCGUCUCUGCCAG 4408 GUUCCCUCGUCUCUGCcAGdTsdT antis
604-623 4409 UGGCAGAGACGAGGGAACU 4410 uGGcAGAGAcGAGGGAAcudTsdT
sense 604-623 4411 AGUUCCCUCGUCUCUGCCA 4412
AGUUCCCUCGUCUCUGCcAdTsdT antis 741-760 4413 GAGAAGAAGGACGAGCUGU
4414 GAGAAGAAGGAcGAGcuGudTsdT sense 741-760 4415
ACAGCUCGUCCUUCUUCUC 4416 AcAGCUCGUCCUUCUUCUCdTsdT antis 752-771
4417 CGAGCUGUAUUUGAAUCUG 4418 cGAGcuGuAuuuGAAucuGdTsdT sense
752-771 4419 CAGAUUCAAAUACAGCUCG 4420 cAGAUUcAAAuAcAGCUCGdTsdT
antis 753-772 4421 GAGCUGUAUUUGAAUCUGG 4422
GAGcuGuAuuuGAAucuGGdTsdT sense 753-772 4423 CCAGAUUCAAAUACAGCUC
4424 CcAGAUUcAAAuAcAGCUCdTsdT antis 831-850 4425
CUGAUCACCCCUAUCAUCU 4426 cuGAucAccccuAucAucudTsdT sense 831-850
4427 AGAUGAUAGGGGUGAUCAG 4428 AGAUGAuAGGGGUGAUcAGdTsdT antis
832-851 4429 UGAUCACCCCUAUCAUCUA 4430 uGAucAccccuAucAucuAdTsdT
sense 832-851 4431 UAGAUGAUAGGGGUGAUCA 4432
uAGAUGAuAGGGGUGAUcAdTsdT antis 833-852 4433 GAUCACCCCUAUCAUCUAC
4434 GAucAccccuAucAucuAcdTsdT sense 833-852 4435
GUAGAUGAUAGGGGUGAUC 4436 GuAGAUGAuAGGGGUGAUCdTsdT antis 913-932
4437 GUCACCGUGACAUCAAGCC 4438 GucAccGuGAcAucAAGccdTsdT sense
913-932 4439 GGCUUGAUGUCACGGUGAC 4440 GGCUUGAUGUcACGGUGACdTsdT
antis 918-937 4441 CGUGACAUCAAGCCCCAGA 4442
cGuGAcAucAAGccccAGAdTsdT sense 918-937 4443 UCUGGGGCUUGAUGUCACG
4444 UCUGGGGCUUGAUGUcACGdTsdT antis 920-939 4445
UGACAUCAAGCCCCAGAAU 4446 uGAcAucAAGccccAGAAudTsdT sense 920-939
4447 AUUCUGGGGCUUGAUGUCA 4448 AUUCUGGGGCUUGAUGUcAdTsdT antis
1018-1037 4449 AUGUGUCCUACAUCUGCUC 4450 AuGuGuccuAcAucuGcucdTsdT
sense 1018-1037 4451 GAGCAGAUGUAGGACACAU 4452
GAGcAGAUGuAGGAcAcAUdTsdT antis 1019-1038 4453 UGUGUCCUACAUCUGCUCU
4454 uGuGuccuAcAucuGcucudTsdT sense 1019-1038 4455
AGAGCAGAUGUAGGACACA 4456 AGAGcAGAUGuAGGAcAcAdTsdT antis 1097-1116
4457 UGUGUGGUCGGCUGGCUGU 4458 uGuGuGGucGGcuGGcuGudTsdT sense
1097-1116 4459 ACAGCCAGCCGACCACACA 4460 AcAGCcAGCCGACcAcAcAdTsdT
antis 1102-1121 4461 GGUCGGCUGGCUGUGUACU 4462
GGucGGcuGGcuGuGuAcudTsdT sense 1102-1121 4463 AGUACACAGCCAGCCGACC
4464 AGuAcAcAGCcAGCCGACCdTsdT antis 1155-1174 4465
GGGGACAGUGGGGUGGACC 4466 GGGGAcAGuGGGGuGGAccdTsdT sense 1155-1174
4467 GGUCCACCCCACUGUCCCC 4468 GGUCcACCCcACUGUCCCCdTsdT antis
1245-1264 4469 ACGGAGUUCAAGUUCCCCC 4470 AcGGAGuucAAGuucccccdTsdT
sense 1245-1264 4471 GGGGGAACUUGAACUCCGU 4472
GGGGGAACUUGAACUCCGUdTsdT antis 1274-1293 4473 UCACCCUUGGACAAAGGUG
4474 ucAcccuuGGAcAAAGGuGdTsdT sense 1274-1293 4475
CACCUUUGUCCAAGGGUGA 4476 cACCUUUGUCcAAGGGUGAdTsdT antis 1276-1295
4477 ACCCUUGGACAAAGGUGUU 4478 AcccuuGGAcAAAGGuGuudTsdT sense
1276-1295 4479 AACACCUUUGUCCAAGGGU 4480 AAcACCUUUGUCcAAGGGUdTsdT
antis 1316-1335 4481 UGAGGCCAUUGCACUCUGC 4482
uGAGGccAuuGcAcucuGcdTsdT sense 1316-1335 4483 GCAGAGUGCAAUGGCCUCA
4484 GcAGAGUGcAAUGGCCUcAdTsdT antis 1318-1337 4485
AGGCCAUUGCACUCUGCUC 4486 AGGccAuuGcAcucuGcucdTsdT sense 1318-1337
4487 GAGCAGAGUGCAAUGGCCU 4488 GAGcAGAGUGcAAUGGCCUdTsdT antis
1321-1340 4489 CCAUUGCACUCUGCUCUAG 4490 ccAuuGcAcucuGcucuAGdTsdT
sense 1321-1340 4491 CUAGAGCAGAGUGCAAUGG 4492
CuAGAGcAGAGUGcAAUGGdTsdT antis 1325-1344 4493 UGCACUCUGCUCUAGCCUA
4494 uGcAcucuGcucuAGccuAdTsdT sense 1325-1344 4495
UAGGCUAGAGCAGAGUGCA 4496 uAGGCuAGAGcAGAGUGcAdTsdT antis 1337-1356
4497 UAGCCUACUGGAGUACACG 4498 uAGccuAcuGGAGuAcAcGdTsdT sense
1337-1356 4499 CGUGUACUCCAGUAGGCUA 4500 CGUGuACUCcAGuAGGCuAdTsdT
antis 1375-1394 4501 CACUCGAGGCUUGUGCCCA 4502
cAcucGAGGcuuGuGcccAdTsdT sense 1375-1394 4503 UGGGCACAAGCCUCGAGUG
4504 UGGGcAcAAGCCUCGAGUGdTsdT antis 1443-1462 4505
CGCCCGCUUCCCCCCCUGU 4506 cGcccGcuucccccccuGudTsdT sense
1443-1462 4507 ACAGGGGGGGAAGCGGGCG 4508 AcAGGGGGGGAAGCGGGCGdTsdT
antis 1466-1485 4509 CUUCAGUCCUGGUGAACUG 4510
cuucAGuccuGGuGAAcuGdTsdT sense 1466-1485 4511 CAGUUCACCAGGACUGAAG
4512 cAGUUcACcAGGACUGAAGdTsdT antis 1581-1600 4513
UCACAAGCUUUAACUGAAG 4514 ucAcAAGcuuuAAcuGAAGdTsdT sense 1581-1600
4515 CUUCAGUUAAAGCUUGUGA 4516 CUUcAGUuAAAGCUUGUGAdTsdT antis
1602-1621 4517 CAGACUGGCCAAGAUUGGC 4518 cAGAcuGGccAAGAuuGGcdTsdT
sense 1602-1621 4519 GCCAAUCUUGGCCAGUCUG 4520
GCcAAUCUUGGCcAGUCUGdTsdT antis 1603-1622 4521 AGACUGGCCAAGAUUGGCA
4522 AGAcuGGccAAGAuuGGcAdTsdT sense 1603-1622 4523
UGCCAAUCUUGGCCAGUCU 4524 UGCcAAUCUUGGCcAGUCUdTsdT antis 1644-1663
4525 ACCCUCGCUAGCUCUUCCU 4526 AcccucGcuAGcucuuccudTsdT sense
1644-1663 4527 AGGAAGAGCUAGCGAGGGU 4528 AGGAAGAGCuAGCGAGGGUdTsdT
antis 1666-1685 4529 GGCCCCACCGACUACCCCU 4530
GGccccAccGAcuAccccudTsdT sense 1666-1685 4531 AGGGGUAGUCGGUGGGGCC
4532 AGGGGuAGUCGGUGGGGCCdTsdT antis 1820-1839 4533
CCUAACCUCUGUGGUGGGC 4534 ccuAAccucuGuGGuGGGcdTsdT sense 1820-1839
4535 GCCCACCACAGAGGUUAGG 4536 GCCcACcAcAGAGGUuAGGdTsdT antis
1821-1840 4537 CUAACCUCUGUGGUGGGCU 4538 cuAAccucuGuGGuGGGcudTsdT
sense 1821-1840 4539 AGCCCACCACAGAGGUUAG 4540
AGCCcACcAcAGAGGUuAGdTsdT antis 1855-1874 4541 UAACUGUUUGUAGGGGAGG
4542 uAAcuGuuuGuAGGGGAGGdTsdT sense 1855-1874 4543
CCUCCCCUACAAACAGUUA 4544 CCUCCCCuAcAAAcAGUuAdTsdT antis 1861-1880
4545 UUUGUAGGGGAGGGGAGAA 4546 uuuGuAGGGGAGGGGAGAAdTsdT sense
1861-1880 4547 UUCUCCCCUCCCCUACAAA 4548 UUCUCCCCUCCCCuAcAAAdTsdT
antis 1912-1931 4549 UUCUACCCCCUUGGUCCCC 4550
uucuAcccccuuGGuccccdTsdT sense 1912-1931 4551 GGGGACCAAGGGGGUAGAA
4552 GGGGACcAAGGGGGuAGAAdTsdT antis 1960-1979 4553
UCCCCCCCUCUCCCAGGUC 4554 ucccccccucucccAGGucdTsdT sense 1960-1979
4555 GACCUGGGAGAGGGGGGGA 4556 GACCUGGGAGAGGGGGGGAdTsdT antis
2009-2028 4557 CUCGUCUUCCCUUCCCUGG 4558 cucGucuucccuucccuGGdTsdT
sense 2009-2028 4559 CCAGGGAAGGGAAGACGAG 4560
CcAGGGAAGGGAAGACGAGdTsdT antis 2010-2029 4561 UCGUCUUCCCUUCCCUGGC
4562 ucGucuucccuucccuGGcdTsdT sense 2010-2029 4563
GCCAGGGAAGGGAAGACGA 4564 GCcAGGGAAGGGAAGACGAdTsdT antis 2011-2030
4565 CGUCUUCCCUUCCCUGGCC 4566 cGucuucccuucccuGGccdTsdT sense
2011-2030 4567 GGCCAGGGAAGGGAAGACG 4568 GGCcAGGGAAGGGAAGACGdTsdT
antis 2223-2242 4569 AGACCUCUGUUCAAUAAAU 4570
AGAccucuGuucAAuAAAudTsdT sense 2223-2242 4571 AUUUAUUGAACAGAGGUCU
4572 AUUuAUUGAAcAGAGGUCUdTsdT antis 2226-2245 4573
CCUCUGUUCAAUAAAUUAU 4574 ccucuGuucAAuAAAuuAudTsdT sense 2226-2245
4575 AUAAUUUAUUGAACAGAGG 4576 AuAAUUuAUUGAAcAGAGGdTsdT antis
2228-2247 4577 UCUGUUCAAUAAAUUAUUG 4578 ucuGuucAAuAAAuuAuuGdTsdT
sense 2228-2247 4579 CAAUAAUUUAUUGAACAGA 4580
cAAuAAUUuAUUGAAcAGAdTsdT antis 9-28 4581 AACGAAGCCGACGGCAGAG 4582
AAcGAAGccGAcGGcAGAGdTsdT sense 9-28 4583 CUCUGCCGUCGGCUUCGUU 4584
CUCUGCCGUCGGCUUCGUUdTsdT antis 10-29 4585 ACGAAGCCGACGGCAGAGG 4586
AcGAAGccGAcGGcAGAGGdTsdT sense 10-29 4587 CCUCUGCCGUCGGCUUCGU 4588
CCUCUGCCGUCGGCUUCGUdTsdT antis 20-39 4589 CGGCAGAGGGACUUCAUCU 4590
cGGcAGAGGGAcuucAucudTsdT sense 20-39 4591 AGAUGAAGUCCCUCUGCCG 4592
AGAUGAAGUCCCUCUGCCGdTsdT antis 26-45 4593 AGGGACUUCAUCUCCCGGC 4594
AGGGAcuucAucucccGGcdTsdT sense 26-45 4595 GCCGGGAGAUGAAGUCCCU 4596
GCCGGGAGAUGAAGUCCCUdTsdT antis 27-46 4597 GGGACUUCAUCUCCCGGCG 4598
GGGAcuucAucucccGGcGdTsdT sense 27-46 4599 CGCCGGGAGAUGAAGUCCC 4600
CGCCGGGAGAUGAAGUCCCdTsdT antis 28-47 4601 GGACUUCAUCUCCCGGCGU 4602
GGAcuucAucucccGGcGudTsdT sense 28-47 4603 ACGCCGGGAGAUGAAGUCC 4604
ACGCCGGGAGAUGAAGUCCdTsdT antis 29-48 4605 GACUUCAUCUCCCGGCGUG 4606
GAcuucAucucccGGcGuGdTsdT sense 29-48 4607 CACGCCGGGAGAUGAAGUC 4608
cACGCCGGGAGAUGAAGUCdTsdT antis 37-56 4609 CUCCCGGCGUGCCCCGCGG 4610
cucccGGcGuGccccGcGGdTsdT sense 37-56 4611 CCGCGGGGCACGCCGGGAG 4612
CCGCGGGGcACGCCGGGAGdTsdT antis 38-57 4613 UCCCGGCGUGCCCCGCGGC 4614
ucccGGcGuGccccGcGGcdTsdT sense 38-57 4615 GCCGCGGGGCACGCCGGGA 4616
GCCGCGGGGcACGCCGGGAdTsdT antis 42-61 4617 GGCGUGCCCCGCGGCGGGC 4618
GGcGuGccccGcGGcGGGcdTsdT sense 42-61 4619 GCCCGCCGCGGGGCACGCC 4620
GCCCGCCGCGGGGcACGCCdTsdT antis 43-62 4621 GCGUGCCCCGCGGCGGGCG 4622
GcGuGccccGcGGcGGGcGdTsdT sense 43-62 4623 CGCCCGCCGCGGGGCACGC 4624
CGCCCGCCGCGGGGcACGCdTsdT antis 59-78 4625 GCGCUGGGCCGGAGCCGGA 4626
GcGcuGGGccGGAGccGGAdTsdT sense 59-78 4627 UCCGGCUCCGGCCCAGCGC 4628
UCCGGCUCCGGCCcAGCGCdTsdT antis 60-79 4629 CGCUGGGCCGGAGCCGGAG 4630
cGcuGGGccGGAGccGGAGdTsdT sense 60-79 4631 CUCCGGCUCCGGCCCAGCG 4632
CUCCGGCUCCGGCCcAGCGdTsdT antis 99-118 4633 AGAGGCCGGAGCCCAGGGG 4634
AGAGGccGGAGcccAGGGGdTsdT sense 99-118 4635 CCCCUGGGCUCCGGCCUCU 4636
CCCCUGGGCUCCGGCCUCUdTsdT antis 108-127 4637 AGCCCAGGGGAGGCGGCGG
4638 AGcccAGGGGAGGcGGcGGdTsdT sense 108-127 4639
CCGCCGCCUCCCCUGGGCU 4640 CCGCCGCCUCCCCUGGGCUdTsdT antis 109-128
4641 GCCCAGGGGAGGCGGCGGC 4642 GcccAGGGGAGGcGGcGGcdTsdT sense
109-128 4643 GCCGCCGCCUCCCCUGGGC 4644 GCCGCCGCCUCCCCUGGGCdTsdT
antis 133-152 4645 CAGCGGCGGGGGCAGCCCA 4646
cAGcGGcGGGGGcAGcccAdTsdT sense 133-152 4647 UGGGCUGCCCCCGCCGCUG
4648 UGGGCUGCCCCCGCCGCUGdTsdT antis 135-154 4649
GCGGCGGGGGCAGCCCAGG 4650 GcGGcGGGGGcAGcccAGGdTsdT sense 135-154
4651 CCUGGGCUGCCCCCGCCGC 4652 CCUGGGCUGCCCCCGCCGCdTsdT antis
136-155 4653 CGGCGGGGGCAGCCCAGGC 4654 cGGcGGGGGcAGcccAGGcdTsdT
sense 136-155 4655 GCCUGGGCUGCCCCCGCCG 4656
GCCUGGGCUGCCCCCGCCGdTsdT antis 140-159 4657 GGGGGCAGCCCAGGCAGCC
4658 GGGGGcAGcccAGGcAGccdTsdT sense 140-159 4659
GGCUGCCUGGGCUGCCCCC 4660 GGCUGCCUGGGCUGCCCCCdTsdT antis 165-184
4661 CCGCGGCCUGGGCCUGCGC 4662 ccGcGGccuGGGccuGcGcdTsdT sense
165-184 4663 GCGCAGGCCCAGGCCGCGG 4664 GCGcAGGCCcAGGCCGCGGdTsdT
antis 170-189 4665 GCCUGGGCCUGCGCUCGGC 4666
GccuGGGccuGcGcucGGcdTsdT sense 170-189 4667 GCCGAGCGCAGGCCCAGGC
4668 GCCGAGCGcAGGCCcAGGCdTsdT antis 171-190 4669
CCUGGGCCUGCGCUCGGCG 4670 ccuGGGccuGcGcucGGcGdTsdT sense 171-190
4671 CGCCGAGCGCAGGCCCAGG 4672 CGCCGAGCGcAGGCCcAGGdTsdT antis
185-204 4673 CGGCGCCAUGAGCGGCGGC 4674 cGGcGccAuGAGcGGcGGcdTsdT
sense 185-204 4675 GCCGCCGCUCAUGGCGCCG 4676
GCCGCCGCUcAUGGCGCCGdTsdT antis 201-220 4677 GGCGGGCCUUCGGGAGGCG
4678 GGcGGGccuucGGGAGGcGdTsdT sense 201-220 4679
CGCCUCCCGAAGGCCCGCC 4680 CGCCUCCCGAAGGCCCGCCdTsdT antis 214-233
4681 GAGGCGGCCCUGGGGGCUC 4682 GAGGcGGcccuGGGGGcucdTsdT sense
214-233 4683 GAGCCCCCAGGGCCGCCUC 4684 GAGCCCCcAGGGCCGCCUCdTsdT
antis 215-234 4685 AGGCGGCCCUGGGGGCUCG 4686
AGGcGGcccuGGGGGcucGdTsdT sense 215-234 4687 CGAGCCCCCAGGGCCGCCU
4688 CGAGCCCCcAGGGCCGCCUdTsdT antis 216-235 4689
GGCGGCCCUGGGGGCUCGG 4690 GGcGGcccuGGGGGcucGGdTsdT sense 216-235
4691 CCGAGCCCCCAGGGCCGCC 4692 CCGAGCCCCcAGGGCCGCCdTsdT antis
227-246 4693 GGGCUCGGGCCGGGCGCGG 4694 GGGcucGGGccGGGcGcGGdTsdT
sense 227-246 4695 CCGCGCCCGGCCCGAGCCC 4696
CCGCGCCCGGCCCGAGCCCdTsdT antis 229-248 4697 GCUCGGGCCGGGCGCGGAC
4698 GcucGGGccGGGcGcGGAcdTsdT sense 229-248 4699
GUCCGCGCCCGGCCCGAGC 4700 GUCCGCGCCCGGCCCGAGCdTsdT antis 230-249
4701 CUCGGGCCGGGCGCGGACC 4702 cucGGGccGGGcGcGGAccdTsdT sense
230-249 4703 GGUCCGCGCCCGGCCCGAG 4704 GGUCCGCGCCCGGCCCGAGdTsdT
antis 290-309 4705 CGGCGGCCCCGGGGGCUCG 4706
cGGcGGccccGGGGGcucGdTsdT sense 290-309 4707 CGAGCCCCCGGGGCCGCCG
4708 CGAGCCCCCGGGGCCGCCGdTsdT antis 292-311 4709
GCGGCCCCGGGGGCUCGGC 4710 GcGGccccGGGGGcucGGcdTsdT sense 292-311
4711 GCCGAGCCCCCGGGGCCGC 4712 GCCGAGCCCCCGGGGCCGCdTsdT antis
293-312 4713 CGGCCCCGGGGGCUCGGCC 4714 cGGccccGGGGGcucGGccdTsdT
sense 293-312 4715 GGCCGAGCCCCCGGGGCCG 4716
GGCCGAGCCCCCGGGGCCGdTsdT antis 299-318 4717 CGGGGGCUCGGCCUCUGGC
4718 cGGGGGcucGGccucuGGcdTsdT sense 299-318 4719
GCCAGAGGCCGAGCCCCCG 4720 GCcAGAGGCCGAGCCCCCGdTsdT antis 300-319
4721 GGGGGCUCGGCCUCUGGCC 4722 GGGGGcucGGccucuGGccdTsdT sense
300-319 4723 GGCCAGAGGCCGAGCCCCC 4724 GGCcAGAGGCCGAGCCCCCdTsdT
antis 302-321 4725 GGGCUCGGCCUCUGGCCCA 4726
GGGcucGGccucuGGcccAdTsdT sense 302-321 4727 UGGGCCAGAGGCCGAGCCC
4728 UGGGCcAGAGGCCGAGCCCdTsdT antis 304-323 4729
GCUCGGCCUCUGGCCCAGG 4730 GcucGGccucuGGcccAGGdTsdT sense 304-323
4731 CCUGGGCCAGAGGCCGAGC 4732 CCUGGGCcAGAGGCCGAGCdTsdT antis
305-324 4733 CUCGGCCUCUGGCCCAGGA 4734 cucGGccucuGGcccAGGAdTsdT
sense 305-324 4735 UCCUGGGCCAGAGGCCGAG 4736
UCCUGGGCcAGAGGCCGAGdTsdT antis 306-325 4737 UCGGCCUCUGGCCCAGGAG
4738 ucGGccucuGGcccAGGAGdTsdT sense 306-325 4739
CUCCUGGGCCAGAGGCCGA 4740 CUCCUGGGCcAGAGGCCGAdTsdT antis 307-326
4741 CGGCCUCUGGCCCAGGAGG 4742 cGGccucuGGcccAGGAGGdTsdT sense
307-326 4743 CCUCCUGGGCCAGAGGCCG 4744 CCUCCUGGGCcAGAGGCCGdTsdT
antis 322-341 4745 GAGGCACUGGCGGCGGGAA 4746
GAGGcAcuGGcGGcGGGAAdTsdT sense 322-341 4747 UUCCCGCCGCCAGUGCCUC
4748 UUCCCGCCGCcAGUGCCUCdTsdT antis 339-358 4749
AAAGCGUCAGUCGGGGCUA 4750 AAAGcGucAGucGGGGcuAdTsdT sense 339-358
4751 UAGCCCCGACUGACGCUUU 4752 uAGCCCCGACUGACGCUUUdTsdT antis
345-364 4753 UCAGUCGGGGCUAUGGGUG 4754 ucAGucGGGGcuAuGGGuGdTsdT
sense 345-364 4755 CACCCAUAGCCCCGACUGA 4756
cACCcAuAGCCCCGACUGAdTsdT antis
346-365 4757 CAGUCGGGGCUAUGGGUGG 4758 cAGucGGGGcuAuGGGuGGdTsdT
sense 346-365 4759 CCACCCAUAGCCCCGACUG 4760
CcACCcAuAGCCCCGACUGdTsdT antis 350-369 4761 CGGGGCUAUGGGUGGGGGC
4762 cGGGGcuAuGGGuGGGGGcdTsdT sense 350-369 4763
GCCCCCACCCAUAGCCCCG 4764 GCCCCcACCcAuAGCCCCGdTsdT antis 374-393
4765 AGCCUCGAGCUCCGGGGGU 4766 AGccucGAGcuccGGGGGudTsdT sense
374-393 4767 ACCCCCGGAGCUCGAGGCU 4768 ACCCCCGGAGCUCGAGGCUdTsdT
antis 378-397 4769 UCGAGCUCCGGGGGUGGCC 4770
ucGAGcuccGGGGGuGGccdTsdT sense 378-397 4771 GGCCACCCCCGGAGCUCGA
4772 GGCcACCCCCGGAGCUCGAdTsdT antis 379-398 4773
CGAGCUCCGGGGGUGGCCC 4774 cGAGcuccGGGGGuGGcccdTsdT sense 379-398
4775 GGGCCACCCCCGGAGCUCG 4776 GGGCcACCCCCGGAGCUCGdTsdT antis
384-403 4777 UCCGGGGGUGGCCCCAGCG 4778 uccGGGGGuGGccccAGcGdTsdT
sense 384-403 4779 CGCUGGGGCCACCCCCGGA 4780
CGCUGGGGCcACCCCCGGAdTsdT antis 394-413 4781 GCCCCAGCGGCAGCGGCGG
4782 GccccAGcGGcAGcGGcGGdTsdT sense 394-413 4783
CCGCCGCUGCCGCUGGGGC 4784 CCGCCGCUGCCGCUGGGGCdTsdT antis 418-437
4785 GCAGCGGUGGCCCCGGCGC 4786 GcAGcGGuGGccccGGcGcdTsdT sense
418-437 4787 GCGCCGGGGCCACCGCUGC 4788 GCGCCGGGGCcACCGCUGCdTsdT
antis 419-438 4789 CAGCGGUGGCCCCGGCGCG 4790
cAGcGGuGGccccGGcGcGdTsdT sense 419-438 4791 CGCGCCGGGGCCACCGCUG
4792 CGCGCCGGGGCcACCGCUGdTsdT antis 421-440 4793
GCGGUGGCCCCGGCGCGGG 4794 GcGGuGGccccGGcGcGGGdTsdT sense 421-440
4795 CCCGCGCCGGGGCCACCGC 4796 CCCGCGCCGGGGCcACCGCdTsdT antis
422-441 4797 CGGUGGCCCCGGCGCGGGC 4798 cGGuGGccccGGcGcGGGcdTsdT
sense 422-441 4799 GCCCGCGCCGGGGCCACCG 4800
GCCCGCGCCGGGGCcACCGdTsdT antis 423-442 4801 GGUGGCCCCGGCGCGGGCA
4802 GGuGGccccGGcGcGGGcAdTsdT sense 423-442 4803
UGCCCGCGCCGGGGCCACC 4804 UGCCCGCGCCGGGGCcACCdTsdT antis 424-443
4805 GUGGCCCCGGCGCGGGCAC 4806 GuGGccccGGcGcGGGcAcdTsdT sense
424-443 4807 GUGCCCGCGCCGGGGCCAC 4808 GUGCCCGCGCCGGGGCcACdTsdT
antis 443-462 4809 UAGCUUCCCGCCGCCGGGA 4810
uAGcuucccGccGccGGGAdTsdT sense 443-462 4811 UCCCGGCGGCGGGAAGCUA
4812 UCCCGGCGGCGGGAAGCuAdTsdT antis 450-469 4813
CCGCCGCCGGGAGUGAAGC 4814 ccGccGccGGGAGuGAAGcdTsdT sense 450-469
4815 GCUUCACUCCCGGCGGCGG 4816 GCUUcACUCCCGGCGGCGGdTsdT antis
455-474 4817 GCCGGGAGUGAAGCUGGGC 4818 GccGGGAGuGAAGcuGGGcdTsdT
sense 455-474 4819 GCCCAGCUUCACUCCCGGC 4820
GCCcAGCUUcACUCCCGGCdTsdT antis 457-476 4821 CGGGAGUGAAGCUGGGCCG
4822 cGGGAGuGAAGcuGGGccGdTsdT sense 457-476 4823
CGGCCCAGCUUCACUCCCG 4824 CGGCCcAGCUUcACUCCCGdTsdT antis 462-481
4825 GUGAAGCUGGGCCGUGACA 4826 GuGAAGcuGGGccGuGAcAdTsdT sense
462-481 4827 UGUCACGGCCCAGCUUCAC 4828 UGUcACGGCCcAGCUUcACdTsdT
antis 467-486 4829 GCUGGGCCGUGACAGCGGG 4830
GcuGGGccGuGAcAGcGGGdTsdT sense 467-486 4831 CCCGCUGUCACGGCCCAGC
4832 CCCGCUGUcACGGCCcAGCdTsdT antis 478-497 4833
ACAGCGGGAAGGUGACCAC 4834 AcAGcGGGAAGGuGAccAcdTsdT sense 478-497
4835 GUGGUCACCUUCCCGCUGU 4836 GUGGUcACCUUCCCGCUGUdTsdT antis
482-501 4837 CGGGAAGGUGACCACAGUG 4838 cGGGAAGGuGAccAcAGuGdTsdT
sense 482-501 4839 CACUGUGGUCACCUUCCCG 4840
cACUGUGGUcACCUUCCCGdTsdT antis 498-517 4841 GUGGUAGCCACUGUAGGCC
4842 GuGGuAGccAcuGuAGGccdTsdT sense 498-517 4843
GGCCUACAGUGGCUACCAC 4844 GGCCuAcAGUGGCuACcACdTsdT antis 499-518
4845 UGGUAGCCACUGUAGGCCA 4846 uGGuAGccAcuGuAGGccAdTsdT sense
499-518 4847 UGGCCUACAGUGGCUACCA 4848 UGGCCuAcAGUGGCuACcAdTsdT
antis 500-519 4849 GGUAGCCACUGUAGGCCAA 4850
GGuAGccAcuGuAGGccAAdTsdT sense 500-519 4851 UUGGCCUACAGUGGCUACC
4852 UUGGCCuAcAGUGGCuACCdTsdT antis 501-520 4853
GUAGCCACUGUAGGCCAAG 4854 GuAGccAcuGuAGGccAAGdTsdT sense 501-520
4855 CUUGGCCUACAGUGGCUAC 4856 CUUGGCCuAcAGUGGCuACdTsdT antis
508-527 4857 CUGUAGGCCAAGGCCCAGA 4858 cuGuAGGccAAGGcccAGAdTsdT
sense 508-527 4859 UCUGGGCCUUGGCCUACAG 4860
UCUGGGCCUUGGCCuAcAGdTsdT antis 514-533 4861 GCCAAGGCCCAGAGCGUUC
4862 GccAAGGcccAGAGcGuucdTsdT sense 514-533 4863
GAACGCUCUGGGCCUUGGC 4864 GAACGCUCUGGGCCUUGGCdTsdT antis 515-534
4865 CCAAGGCCCAGAGCGUUCC 4866 ccAAGGcccAGAGcGuuccdTsdT sense
515-534 4867 GGAACGCUCUGGGCCUUGG 4868 GGAACGCUCUGGGCCUUGGdTsdT
antis 540-559 4869 GUGGCUUACACUGACAUCA 4870
GuGGcuuAcAcuGAcAucAdTsdT sense 540-559 4871 UGAUGUCAGUGUAAGCCAC
4872 UGAUGUcAGUGuAAGCcACdTsdT antis 541-560 4873
UGGCUUACACUGACAUCAA 4874 uGGcuuAcAcuGAcAucAAdTsdT sense 541-560
4875 UUGAUGUCAGUGUAAGCCA 4876 UUGAUGUcAGUGuAAGCcAdTsdT antis
543-562 4877 GCUUACACUGACAUCAAAG 4878 GcuuAcAcuGAcAucAAAGdTsdT
sense 543-562 4879 CUUUGAUGUCAGUGUAAGC 4880
CUUUGAUGUcAGUGuAAGCdTsdT antis 546-565 4881 UACACUGACAUCAAAGUGA
4882 uAcAcuGAcAucAAAGuGAdTsdT sense 546-565 4883
UCACUUUGAUGUCAGUGUA 4884 UcACUUUGAUGUcAGUGuAdTsdT antis 594-613
4885 CAGGCACGGCUGGCAGAGA 4886 cAGGcAcGGcuGGcAGAGAdTsdT sense
594-613 4887 UCUCUGCCAGCCGUGCCUG 4888 UCUCUGCcAGCCGUGCCUGdTsdT
antis 605-624 4889 GGCAGAGACGAGGGAACUG 4890
GGcAGAGAcGAGGGAAcuGdTsdT sense 605-624 4891 CAGUUCCCUCGUCUCUGCC
4892 cAGUUCCCUCGUCUCUGCCdTsdT antis 607-626 4893
CAGAGACGAGGGAACUGGU 4894 cAGAGAcGAGGGAAcuGGudTsdT sense 607-626
4895 ACCAGUUCCCUCGUCUCUG 4896 ACcAGUUCCCUCGUCUCUGdTsdT antis
617-636 4897 GGAACUGGUGGCCAUCAAG 4898 GGAAcuGGuGGccAucAAGdTsdT
sense 617-636 4899 CUUGAUGGCCACCAGUUCC 4900
CUUGAUGGCcACcAGUUCCdTsdT antis 618-637 4901 GAACUGGUGGCCAUCAAGA
4902 GAAcuGGuGGccAucAAGAdTsdT sense 618-637 4903
UCUUGAUGGCCACCAGUUC 4904 UCUUGAUGGCcACcAGUUCdTsdT antis 619-638
4905 AACUGGUGGCCAUCAAGAA 4906 AAcuGGuGGccAucAAGAAdTsdT sense
619-638 4907 UUCUUGAUGGCCACCAGUU 4908 UUCUUGAUGGCcACcAGUUdTsdT
antis 624-643 4909 GUGGCCAUCAAGAAGGUUC 4910
GuGGccAucAAGAAGGuucdTsdT sense 624-643 4911 GAACCUUCUUGAUGGCCAC
4912 GAACCUUCUUGAUGGCcACdTsdT antis 625-644 4913
UGGCCAUCAAGAAGGUUCU 4914 uGGccAucAAGAAGGuucudTsdT sense 625-644
4915 AGAACCUUCUUGAUGGCCA 4916 AGAACCUUCUUGAUGGCcAdTsdT antis
647-666 4917 GGACAAAAGGUUCAAGAAC 4918 GGAcAAAAGGuucAAGAAcdTsdT
sense 647-666 4919 GUUCUUGAACCUUUUGUCC 4920
GUUCUUGAACCUUUUGUCCdTsdT antis 648-667 4921 GACAAAAGGUUCAAGAACC
4922 GAcAAAAGGuucAAGAAccdTsdT sense 648-667 4923
GGUUCUUGAACCUUUUGUC 4924 GGUUCUUGAACCUUUUGUCdTsdT antis 666-685
4925 CGAGAACUGCAGAUUAUGC 4926 cGAGAAcuGcAGAuuAuGcdTsdT sense
666-685 4927 GCAUAAUCUGCAGUUCUCG 4928 GcAuAAUCUGcAGUUCUCGdTsdT
antis 713-732 4929 GCUGCGGUACUUUUUCUAC 4930
GcuGcGGuAcuuuuucuAcdTsdT sense 713-732 4931 GUAGAAAAAGUACCGCAGC
4932 GuAGAAAAAGuACCGcAGCdTsdT antis 717-736 4933
CGGUACUUUUUCUACUCCA 4934 cGGuAcuuuuucuAcuccAdTsdT sense 717-736
4935 UGGAGUAGAAAAAGUACCG 4936 UGGAGuAGAAAAAGuACCGdTsdT antis
739-758 4937 GGGAGAAGAAGGACGAGCU 4938 GGGAGAAGAAGGAcGAGcudTsdT
sense 739-758 4939 AGCUCGUCCUUCUUCUCCC 4940
AGCUCGUCCUUCUUCUCCCdTsdT antis 740-759 4941 GGAGAAGAAGGACGAGCUG
4942 GGAGAAGAAGGAcGAGcuGdTsdT sense 740-759 4943
CAGCUCGUCCUUCUUCUCC 4944 cAGCUCGUCCUUCUUCUCCdTsdT antis 794-813
4945 GGUGUACCGAGUGGCCCGC 4946 GGuGuAccGAGuGGcccGcdTsdT sense
794-813 4947 GCGGGCCACUCGGUACACC 4948 GCGGGCcACUCGGuAcACCdTsdT
antis 798-817 4949 UACCGAGUGGCCCGCCACU 4950
uAccGAGuGGcccGccAcudTsdT sense 798-817 4951 AGUGGCGGGCCACUCGGUA
4952 AGUGGCGGGCcACUCGGuAdTsdT antis 822-841 4953
AAGGCCAAGCUGAUCACCC 4954 AAGGccAAGcuGAucAcccdTsdT sense 822-841
4955 GGGUGAUCAGCUUGGCCUU 4956 GGGUGAUcAGCUUGGCCUUdTsdT antis
823-842 4957 AGGCCAAGCUGAUCACCCC 4958 AGGccAAGcuGAucAccccdTsdT
sense 823-842 4959 GGGGUGAUCAGCUUGGCCU 4960
GGGGUGAUcAGCUUGGCCUdTsdT antis 846-865 4961 AUCUACAUCAAGGUGUACA
4962 AucuAcAucAAGGuGuAcAdTsdT sense 846-865 4963
UGUACACCUUGAUGUAGAU 4964 UGuAcACCUUGAUGuAGAUdTsdT antis 847-866
4965 UCUACAUCAAGGUGUACAU 4966 ucuAcAucAAGGuGuAcAudTsdT sense
847-866 4967 AUGUACACCUUGAUGUAGA 4968 AUGuAcACCUUGAUGuAGAdTsdT
antis 848-867 4969 CUACAUCAAGGUGUACAUG 4970
cuAcAucAAGGuGuAcAuGdTsdT sense 848-867 4971 CAUGUACACCUUGAUGUAG
4972 cAUGuAcACCUUGAUGuAGdTsdT antis 849-868 4973
UACAUCAAGGUGUACAUGU 4974 uAcAucAAGGuGuAcAuGudTsdT sense 849-868
4975 ACAUGUACACCUUGAUGUA 4976 AcAUGuAcACCUUGAUGuAdTsdT antis
889-908 4977 CCUACAUCCACUCCCAAGG 4978 ccuAcAuccAcucccAAGGdTsdT
sense 889-908 4979 CCUUGGGAGUGGAUGUAGG 4980
CCUUGGGAGUGGAUGuAGGdTsdT antis 892-911 4981 ACAUCCACUCCCAAGGUGU
4982 AcAuccAcucccAAGGuGudTsdT sense 892-911 4983
ACACCUUGGGAGUGGAUGU 4984 AcACCUUGGGAGUGGAUGUdTsdT antis 893-912
4985 CAUCCACUCCCAAGGUGUG 4986 cAuccAcucccAAGGuGuGdTsdT sense
893-912 4987 CACACCUUGGGAGUGGAUG 4988 cAcACCUUGGGAGUGGAUGdTsdT
antis 904-923 4989 AAGGUGUGUGUCACCGUGA 4990
AAGGuGuGuGucAccGuGAdTsdT sense 904-923 4991 UCACGGUGACACACACCUU
4992 UcACGGUGAcAcAcACCUUdTsdT antis 905-924 4993
AGGUGUGUGUCACCGUGAC 4994 AGGuGuGuGucAccGuGAcdTsdT sense 905-924
4995 GUCACGGUGACACACACCU 4996 GUcACGGUGAcAcAcACCUdTsdT antis
906-925 4997 GGUGUGUGUCACCGUGACA 4998 GGuGuGuGucAccGuGAcAdTsdT
sense 906-925 4999 UGUCACGGUGACACACACC 5000
UGUcACGGUGAcAcAcACCdTsdT antis 907-926 5001 GUGUGUGUCACCGUGACAU
5002 GuGuGuGucAccGuGAcAudTsdT sense 907-926 5003
AUGUCACGGUGACACACAC 5004 AUGUcACGGUGAcAcAcACdTsdT antis 908-927
5005 UGUGUGUCACCGUGACAUC 5006 uGuGuGucAccGuGAcAucdTsdT sense
908-927 5007 GAUGUCACGGUGACACACA 5008 GAUGUcACGGUGAcAcAcAdTsdT
antis
909-928 5009 GUGUGUCACCGUGACAUCA 5010 GuGuGucAccGuGAcAucAdTsdT
sense 909-928 5011 UGAUGUCACGGUGACACAC 5012
UGAUGUcACGGUGAcAcACdTsdT antis 910-929 5013 UGUGUCACCGUGACAUCAA
5014 uGuGucAccGuGAcAucAAdTsdT sense 910-929 5015
UUGAUGUCACGGUGACACA 5016 UUGAUGUcACGGUGAcAcAdTsdT antis 919-938
5017 GUGACAUCAAGCCCCAGAA 5018 GuGAcAucAAGccccAGAAdTsdT sense
919-938 5019 UUCUGGGGCUUGAUGUCAC 5020 UUCUGGGGCUUGAUGUcACdTsdT
antis 946-965 5021 UGGACCCUGACACUGCUGU 5022
uGGAcccuGAcAcuGcuGudTsdT sense 946-965 5023 ACAGCAGUGUCAGGGUCCA
5024 AcAGcAGUGUcAGGGUCcAdTsdT antis 950-969 5025
CCCUGACACUGCUGUCCUC 5026 cccuGAcAcuGcuGuccucdTsdT sense 950-969
5027 GAGGACAGCAGUGUCAGGG 5028 GAGGAcAGcAGUGUcAGGGdTsdT antis
957-976 5029 ACUGCUGUCCUCAAGCUCU 5030 AcuGcuGuccucAAGcucudTsdT
sense 957-976 5031 AGAGCUUGAGGACAGCAGU 5032
AGAGCUUGAGGAcAGcAGUdTsdT antis 961-980 5033 CUGUCCUCAAGCUCUGCGA
5034 cuGuccucAAGcucuGcGAdTsdT sense 961-980 5035
UCGCAGAGCUUGAGGACAG 5036 UCGcAGAGCUUGAGGAcAGdTsdT antis 962-981
5037 UGUCCUCAAGCUCUGCGAU 5038 uGuccucAAGcucuGcGAudTsdT sense
962-981 5039 AUCGCAGAGCUUGAGGACA 5040 AUCGcAGAGCUUGAGGAcAdTsdT
antis 1020-1039 5041 GUGUCCUACAUCUGCUCUC 5042
GuGuccuAcAucuGcucucdTsdT sense 1020-1039 5043 GAGAGCAGAUGUAGGACAC
5044 GAGAGcAGAUGuAGGAcACdTsdT antis 1029-1048 5045
AUCUGCUCUCGGUACUACC 5046 AucuGcucucGGuAcuAccdTsdT sense 1029-1048
5047 GGUAGUACCGAGAGCAGAU 5048 GGuAGuACCGAGAGcAGAUdTsdT antis
1048-1067 5049 GUGCUCCAGAACUCAUCUU 5050 GuGcuccAGAAcucAucuudTsdT
sense 1048-1067 5051 AAGAUGAGUUCUGGAGCAC 5052
AAGAUGAGUUCUGGAGcACdTsdT antis 1049-1068 5053 UGCUCCAGAACUCAUCUUU
5054 uGcuccAGAAcucAucuuudTsdT sense 1049-1068 5055
AAAGAUGAGUUCUGGAGCA 5056 AAAGAUGAGUUCUGGAGcAdTsdT antis 1050-1069
5057 GCUCCAGAACUCAUCUUUG 5058 GcuccAGAAcucAucuuuGdTsdT sense
1050-1069 5059 CAAAGAUGAGUUCUGGAGC 5060 cAAAGAUGAGUUCUGGAGCdTsdT
antis 1059-1078 5061 CUCAUCUUUGGAGCCACAG 5062
cucAucuuuGGAGccAcAGdTsdT sense 1059-1078 5063 CUGUGGCUCCAAAGAUGAG
5064 CUGUGGCUCcAAAGAUGAGdTsdT antis 1087-1106 5065
CGUCCAUCGAUGUGUGGUC 5066 cGuccAucGAuGuGuGGucdTsdT sense 1087-1106
5067 GACCACACAUCGAUGGACG 5068 GACcAcAcAUCGAUGGACGdTsdT antis
1096-1115 5069 AUGUGUGGUCGGCUGGCUG 5070 AuGuGuGGucGGcuGGcuGdTsdT
sense 1096-1115 5071 CAGCCAGCCGACCACACAU 5072
cAGCcAGCCGACcAcAcAUdTsdT antis 1130-1149 5073 ACUUCUCGGCCAGCCCAUC
5074 AcuucucGGccAGcccAucdTsdT sense 1130-1149 5075
GAUGGGCUGGCCGAGAAGU 5076 GAUGGGCUGGCCGAGAAGUdTsdT antis 1134-1153
5077 CUCGGCCAGCCCAUCUUCC 5078 cucGGccAGcccAucuuccdTsdT sense
1134-1153 5079 GGAAGAUGGGCUGGCCGAG 5080 GGAAGAUGGGCUGGCCGAGdTsdT
antis 1141-1160 5081 AGCCCAUCUUCCCUGGGGA 5082
AGcccAucuucccuGGGGAdTsdT sense 1141-1160 5083 UCCCCAGGGAAGAUGGGCU
5084 UCCCcAGGGAAGAUGGGCUdTsdT antis 1144-1163 5085
CCAUCUUCCCUGGGGACAG 5086 ccAucuucccuGGGGAcAGdTsdT sense 1144-1163
5087 CUGUCCCCAGGGAAGAUGG 5088 CUGUCCCcAGGGAAGAUGGdTsdT antis
1151-1170 5089 CCCUGGGGACAGUGGGGUG 5090 cccuGGGGAcAGuGGGGuGdTsdT
sense 1151-1170 5091 CACCCCACUGUCCCCAGGG 5092
cACCCcACUGUCCCcAGGGdTsdT antis 1156-1175 5093 GGGACAGUGGGGUGGACCA
5094 GGGAcAGuGGGGuGGAccAdTsdT sense 1156-1175 5095
UGGUCCACCCCACUGUCCC 5096 UGGUCcACCCcACUGUCCCdTsdT antis 1157-1176
5097 GGACAGUGGGGUGGACCAG 5098 GGAcAGuGGGGuGGAccAGdTsdT sense
1157-1176 5099 CUGGUCCACCCCACUGUCC 5100 CUGGUCcACCCcACUGUCCdTsdT
antis 1158-1177 5101 GACAGUGGGGUGGACCAGC 5102
GAcAGuGGGGuGGAccAGcdTsdT sense 1158-1177 5103 GCUGGUCCACCCCACUGUC
5104 GCUGGUCcACCCcACUGUCdTsdT antis 1159-1178 5105
ACAGUGGGGUGGACCAGCU 5106 AcAGuGGGGuGGAccAGcudTsdT sense 1159-1178
5107 AGCUGGUCCACCCCACUGU 5108 AGCUGGUCcACCCcACUGUdTsdT antis
1160-1179 5109 CAGUGGGGUGGACCAGCUU 5110 cAGuGGGGuGGAccAGcuudTsdT
sense 1160-1179 5111 AAGCUGGUCCACCCCACUG 5112
AAGCUGGUCcACCCcACUGdTsdT antis 1244-1263 5113 UACGGAGUUCAAGUUCCCC
5114 uAcGGAGuucAAGuuccccdTsdT sense 1244-1263 5115
GGGGAACUUGAACUCCGUA 5116 GGGGAACUUGAACUCCGuAdTsdT antis 1246-1265
5117 CGGAGUUCAAGUUCCCCCA 5118 cGGAGuucAAGuucccccAdTsdT sense
1246-1265 5119 UGGGGGAACUUGAACUCCG 5120 UGGGGGAACUUGAACUCCGdTsdT
antis 1273-1292 5121 CUCACCCUUGGACAAAGGU 5122
cucAcccuuGGAcAAAGGudTsdT sense 1273-1292 5123 ACCUUUGUCCAAGGGUGAG
5124 ACCUUUGUCcAAGGGUGAGdTsdT antis 1275-1294 5125
CACCCUUGGACAAAGGUGU 5126 cAcccuuGGAcAAAGGuGudTsdT sense 1275-1294
5127 ACACCUUUGUCCAAGGGUG 5128 AcACCUUUGUCcAAGGGUGdTsdT antis
1278-1297 5129 CCUUGGACAAAGGUGUUCA 5130 ccuuGGAcAAAGGuGuucAdTsdT
sense 1278-1297 5131 UGAACACCUUUGUCCAAGG 5132
UGAAcACCUUUGUCcAAGGdTsdT antis 1279-1298 5133 CUUGGACAAAGGUGUUCAA
5134 cuuGGAcAAAGGuGuucAAdTsdT sense 1279-1298 5135
UUGAACACCUUUGUCCAAG 5136 UUGAAcACCUUUGUCcAAGdTsdT antis 1288-1307
5137 AGGUGUUCAAAUCUUCAAA 5138 AGGuGuucAAAucuucAAAdTsdT sense
1288-1307 5139 UUUGAAGAUUUGAACACCU 5140 UUUGAAGAUUUGAAcACCUdTsdT
antis 1291-1310 5141 UGUUCAAAUCUUCAAAGAC 5142
uGuucAAAucuucAAAGAcdTsdT sense 1291-1310 5143 GUCUUUGAAGAUUUGAACA
5144 GUCUUUGAAGAUUUGAAcAdTsdT antis 1292-1311 5145
GUUCAAAUCUUCAAAGACA 5146 GuucAAAucuucAAAGAcAdTsdT sense 1292-1311
5147 UGUCUUUGAAGAUUUGAAC 5148 UGUCUUUGAAGAUUUGAACdTsdT antis
1293-1312 5149 UUCAAAUCUUCAAAGACAC 5150 uucAAAucuucAAAGAcAcdTsdT
sense 1293-1312 5151 GUGUCUUUGAAGAUUUGAA 5152
GUGUCUUUGAAGAUUUGAAdTsdT antis 1294-1313 5153 UCAAAUCUUCAAAGACACC
5154 ucAAAucuucAAAGAcAccdTsdT sense 1294-1313 5155
GGUGUCUUUGAAGAUUUGA 5156 GGUGUCUUUGAAGAUUUGAdTsdT antis 1314-1333
5157 CCUGAGGCCAUUGCACUCU 5158 ccuGAGGccAuuGcAcucudTsdT sense
1314-1333 5159 AGAGUGCAAUGGCCUCAGG 5160 AGAGUGcAAUGGCCUcAGGdTsdT
antis 1320-1339 5161 GCCAUUGCACUCUGCUCUA 5162
GccAuuGcAcucuGcucuAdTsdT sense 1320-1339 5163 UAGAGCAGAGUGCAAUGGC
5164 uAGAGcAGAGUGcAAUGGCdTsdT antis 1336-1355 5165
CUAGCCUACUGGAGUACAC 5166 cuAGccuAcuGGAGuAcAcdTsdT sense 1336-1355
5167 GUGUACUCCAGUAGGCUAG 5168 GUGuACUCcAGuAGGCuAGdTsdT antis
1353-1372 5169 ACGCCAUCCUCAAGGCUCU 5170 AcGccAuccucAAGGcucudTsdT
sense 1353-1372 5171 AGAGCCUUGAGGAUGGCGU 5172
AGAGCCUUGAGGAUGGCGUdTsdT antis 1355-1374 5173 GCCAUCCUCAAGGCUCUCC
5174 GccAuccucAAGGcucuccdTsdT sense 1355-1374 5175
GGAGAGCCUUGAGGAUGGC 5176 GGAGAGCCUUGAGGAUGGCdTsdT antis 1359-1378
5177 UCCUCAAGGCUCUCCCCAC 5178 uccucAAGGcucuccccAcdTsdT sense
1359-1378 5179 GUGGGGAGAGCCUUGAGGA 5180 GUGGGGAGAGCCUUGAGGAdTsdT
antis 1372-1391 5181 CCCCACUCGAGGCUUGUGC 5182
ccccAcucGAGGcuuGuGcdTsdT sense 1372-1391 5183 GCACAAGCCUCGAGUGGGG
5184 GcAcAAGCCUCGAGUGGGGdTsdT antis 1373-1392 5185
CCCACUCGAGGCUUGUGCC 5186 cccAcucGAGGcuuGuGccdTsdT sense 1373-1392
5187 GGCACAAGCCUCGAGUGGG 5188 GGcAcAAGCCUCGAGUGGGdTsdT antis
1374-1393 5189 CCACUCGAGGCUUGUGCCC 5190 ccAcucGAGGcuuGuGcccdTsdT
sense 1374-1393 5191 GGGCACAAGCCUCGAGUGG 5192
GGGcAcAAGCCUCGAGUGGdTsdT antis 1376-1395 5193 ACUCGAGGCUUGUGCCCAC
5194 AcucGAGGcuuGuGcccAcdTsdT sense 1376-1395 5195
GUGGGCACAAGCCUCGAGU 5196 GUGGGcAcAAGCCUCGAGUdTsdT antis 1377-1396
5197 CUCGAGGCUUGUGCCCACA 5198 cucGAGGcuuGuGcccAcAdTsdT sense
1377-1396 5199 UGUGGGCACAAGCCUCGAG 5200 UGUGGGcAcAAGCCUCGAGdTsdT
antis 1378-1397 5201 UCGAGGCUUGUGCCCACAG 5202
ucGAGGcuuGuGcccAcAGdTsdT sense 1378-1397 5203 CUGUGGGCACAAGCCUCGA
5204 CUGUGGGcAcAAGCCUCGAdTsdT antis 1389-1408 5205
GCCCACAGCUUCUUCGAUG 5206 GcccAcAGcuucuucGAuGdTsdT sense 1389-1408
5207 CAUCGAAGAAGCUGUGGGC 5208 cAUCGAAGAAGCUGUGGGCdTsdT antis
1391-1410 5209 CCACAGCUUCUUCGAUGAA 5210 ccAcAGcuucuucGAuGAAdTsdT
sense 1391-1410 5211 UUCAUCGAAGAAGCUGUGG 5212
UUcAUCGAAGAAGCUGUGGdTsdT antis 1423-1442 5213 GAGCCCAGCUCCCCAACGA
5214 GAGcccAGcuccccAAcGAdTsdT sense 1423-1442 5215
UCGUUGGGGAGCUGGGCUC 5216 UCGUUGGGGAGCUGGGCUCdTsdT antis 1469-1488
5217 CAGUCCUGGUGAACUGUCC 5218 cAGuccuGGuGAAcuGuccdTsdT sense
1469-1488 5219 GGACAGUUCACCAGGACUG 5220 GGAcAGUUcACcAGGACUGdTsdT
antis 1484-1503 5221 GUCCAUCCAACCAUCUCUC 5222
GuccAuccAAccAucucucdTsdT sense 1484-1503 5223 GAGAGAUGGUUGGAUGGAC
5224 GAGAGAUGGUUGGAUGGACdTsdT antis 1496-1515 5225
AUCUCUCAAUGCCAUUCUC 5226 AucucucAAuGccAuucucdTsdT sense 1496-1515
5227 GAGAAUGGCAUUGAGAGAU 5228 GAGAAUGGcAUUGAGAGAUdTsdT antis
1498-1517 5229 CUCUCAAUGCCAUUCUCAU 5230 cucucAAuGccAuucucAudTsdT
sense 1498-1517 5231 AUGAGAAUGGCAUUGAGAG 5232
AUGAGAAUGGcAUUGAGAGdTsdT antis 1499-1518 5233 UCUCAAUGCCAUUCUCAUC
5234 ucucAAuGccAuucucAucdTsdT sense 1499-1518 5235
GAUGAGAAUGGCAUUGAGA 5236 GAUGAGAAUGGcAUUGAGAdTsdT antis 1502-1521
5237 CAAUGCCAUUCUCAUCCCU 5238 cAAuGccAuucucAucccudTsdT sense
1502-1521 5239 AGGGAUGAGAAUGGCAUUG 5240 AGGGAUGAGAAUGGcAUUGdTsdT
antis 1541-1560 5241 AGGCCCUGCUUCUCCCCUC 5242
AGGcccuGcuucuccccucdTsdT sense 1541-1560 5243 GAGGGGAGAAGCAGGGCCU
5244 GAGGGGAGAAGcAGGGCCUdTsdT antis 1542-1561 5245
GGCCCUGCUUCUCCCCUCA 5246 GGcccuGcuucuccccucAdTsdT sense 1542-1561
5247 UGAGGGGAGAAGCAGGGCC 5248 UGAGGGGAGAAGcAGGGCCdTsdT antis
1548-1567 5249 GCUUCUCCCCUCACCACUU 5250 GcuucuccccucAccAcuudTsdT
sense 1548-1567 5251 AAGUGGUGAGGGGAGAAGC 5252
AAGUGGUGAGGGGAGAAGCdTsdT antis 1549-1568 5253 CUUCUCCCCUCACCACUUC
5254 cuucuccccucAccAcuucdTsdT sense 1549-1568 5255
GAAGUGGUGAGGGGAGAAG 5256 GAAGUGGUGAGGGGAGAAGdTsdT antis 1552-1571
5257 CUCCCCUCACCACUUCCUA 5258 cuccccucAccAcuuccuAdTsdT sense
1552-1571 5259 UAGGAAGUGGUGAGGGGAG 5260 uAGGAAGUGGUGAGGGGAGdTsdT
antis 1557-1576 5261 CUCACCACUUCCUACAACC 5262
cucAccAcuuccuAcAAccdTsdT sense 1557-1576 5263 GGUUGUAGGAAGUGGUGAG
5264 GGUUGuAGGAAGUGGUGAGdTsdT antis 1575-1594 5265
CCAUCCUCACAAGCUUUAA 5266 ccAuccucAcAAGcuuuAAdTsdT sense 1575-1594
5267 UUAAAGCUUGUGAGGAUGG 5268 UuAAAGCUUGUGAGGAUGGdTsdT antis
1600-1619 5269 CUCAGACUGGCCAAGAUUG 5270 cucAGAcuGGccAAGAuuGdTsdT
sense 1600-1619 5271 CAAUCUUGGCCAGUCUGAG 5272
cAAUCUUGGCcAGUCUGAGdTsdT antis 1616-1635 5273 UUGGCAGCCAUCUGAUGCC
5274 uuGGcAGccAucuGAuGccdTsdT sense 1616-1635 5275
GGCAUCAGAUGGCUGCCAA 5276 GGcAUcAGAUGGCUGCcAAdTsdT antis 1617-1636
5277 UGGCAGCCAUCUGAUGCCA 5278 uGGcAGccAucuGAuGccAdTsdT sense
1617-1636 5279 UGGCAUCAGAUGGCUGCCA 5280 UGGcAUcAGAUGGCUGCcAdTsdT
antis 1618-1637 5281 GGCAGCCAUCUGAUGCCAC 5282
GGcAGccAucuGAuGccAcdTsdT sense 1618-1637 5283 GUGGCAUCAGAUGGCUGCC
5284 GUGGcAUcAGAUGGCUGCCdTsdT antis 1619-1638 5285
GCAGCCAUCUGAUGCCACA 5286 GcAGccAucuGAuGccAcAdTsdT sense 1619-1638
5287 UGUGGCAUCAGAUGGCUGC 5288 UGUGGcAUcAGAUGGCUGCdTsdT antis
1622-1641 5289 GCCAUCUGAUGCCACAACU 5290 GccAucuGAuGccAcAAcudTsdT
sense 1622-1641 5291 AGUUGUGGCAUCAGAUGGC 5292
AGUUGUGGcAUcAGAUGGCdTsdT antis 1647-1666 5293 CUCGCUAGCUCUUCCUGAG
5294 cucGcuAGcucuuccuGAGdTsdT sense 1647-1666 5295
CUCAGGAAGAGCUAGCGAG 5296 CUcAGGAAGAGCuAGCGAGdTsdT antis 1648-1667
5297 UCGCUAGCUCUUCCUGAGG 5298 ucGcuAGcucuuccuGAGGdTsdT sense
1648-1667 5299 CCUCAGGAAGAGCUAGCGA 5300 CCUcAGGAAGAGCuAGCGAdTsdT
antis 1649-1668 5301 CGCUAGCUCUUCCUGAGGG 5302
cGcuAGcucuuccuGAGGGdTsdT sense 1649-1668 5303 CCCUCAGGAAGAGCUAGCG
5304 CCCUcAGGAAGAGCuAGCGdTsdT antis 1658-1677 5305
UUCCUGAGGGCCCCACCGA 5306 uuccuGAGGGccccAccGAdTsdT sense 1658-1677
5307 UCGGUGGGGCCCUCAGGAA 5308 UCGGUGGGGCCCUcAGGAAdTsdT antis
1661-1680 5309 CUGAGGGCCCCACCGACUA 5310 cuGAGGGccccAccGAcuAdTsdT
sense 1661-1680 5311 UAGUCGGUGGGGCCCUCAG 5312
uAGUCGGUGGGGCCCUcAGdTsdT antis 1662-1681 5313 UGAGGGCCCCACCGACUAC
5314 uGAGGGccccAccGAcuAcdTsdT sense 1662-1681 5315
GUAGUCGGUGGGGCCCUCA 5316 GuAGUCGGUGGGGCCCUcAdTsdT antis 1663-1682
5317 GAGGGCCCCACCGACUACC 5318 GAGGGccccAccGAcuAccdTsdT sense
1663-1682 5319 GGUAGUCGGUGGGGCCCUC 5320 GGuAGUCGGUGGGGCCCUCdTsdT
antis 1800-1819 5321 AUCUAGGCCUCCCUCAGCA 5322
AucuAGGccucccucAGcAdTsdT sense 1800-1819 5323 UGCUGAGGGAGGCCUAGAU
5324 UGCUGAGGGAGGCCuAGAUdTsdT antis 1807-1826 5325
CCUCCCUCAGCAGCCUAAC 5326 ccucccucAGcAGccuAAcdTsdT sense 1807-1826
5327 GUUAGGCUGCUGAGGGAGG 5328 GUuAGGCUGCUGAGGGAGGdTsdT antis
1819-1838 5329 GCCUAACCUCUGUGGUGGG 5330 GccuAAccucuGuGGuGGGdTsdT
sense 1819-1838 5331 CCCACCACAGAGGUUAGGC 5332
CCcACcAcAGAGGUuAGGCdTsdT antis 1856-1875 5333 AACUGUUUGUAGGGGAGGG
5334 AAcuGuuuGuAGGGGAGGGdTsdT sense 1856-1875 5335
CCCUCCCCUACAAACAGUU 5336 CCCUCCCCuAcAAAcAGUUdTsdT antis 1860-1879
5337 GUUUGUAGGGGAGGGGAGA 5338 GuuuGuAGGGGAGGGGAGAdTsdT sense
1860-1879 5339 UCUCCCCUCCCCUACAAAC 5340 UCUCCCCUCCCCuAcAAACdTsdT
antis 1864-1883 5341 GUAGGGGAGGGGAGAAAAG 5342
GuAGGGGAGGGGAGAAAAGdTsdT sense 1864-1883 5343 CUUUUCUCCCCUCCCCUAC
5344 CUUUUCUCCCCUCCCCuACdTsdT antis 1879-1898 5345
AAAGGAAGGACGGGGUUUG 5346 AAAGGAAGGAcGGGGuuuGdTsdT sense 1879-1898
5347 CAAACCCCGUCCUUCCUUU 5348 cAAACCCCGUCCUUCCUUUdTsdT antis
1880-1899 5349 AAGGAAGGACGGGGUUUGG 5350 AAGGAAGGAcGGGGuuuGGdTsdT
sense 1880-1899 5351 CCAAACCCCGUCCUUCCUU 5352
CcAAACCCCGUCCUUCCUUdTsdT antis 1881-1900 5353 AGGAAGGACGGGGUUUGGG
5354 AGGAAGGAcGGGGuuuGGGdTsdT sense 1881-1900 5355
CCCAAACCCCGUCCUUCCU 5356 CCcAAACCCCGUCCUUCCUdTsdT antis 1906-1925
5357 AGGACCUUCUACCCCCUUG 5358 AGGAccuucuAcccccuuGdTsdT sense
1906-1925 5359 CAAGGGGGUAGAAGGUCCU 5360 cAAGGGGGuAGAAGGUCCUdTsdT
antis 1907-1926 5361 GGACCUUCUACCCCCUUGG 5362
GGAccuucuAcccccuuGGdTsdT sense 1907-1926 5363 CCAAGGGGGUAGAAGGUCC
5364 CcAAGGGGGuAGAAGGUCCdTsdT antis 1908-1927 5365
GACCUUCUACCCCCUUGGU 5366 GAccuucuAcccccuuGGudTsdT sense 1908-1927
5367 ACCAAGGGGGUAGAAGGUC 5368 ACcAAGGGGGuAGAAGGUCdTsdT antis
1909-1928 5369 ACCUUCUACCCCCUUGGUC 5370 AccuucuAcccccuuGGucdTsdT
sense 1909-1928 5371 GACCAAGGGGGUAGAAGGU 5372
GACcAAGGGGGuAGAAGGUdTsdT antis 1910-1929 5373 CCUUCUACCCCCUUGGUCC
5374 ccuucuAcccccuuGGuccdTsdT sense 1910-1929 5375
GGACCAAGGGGGUAGAAGG 5376 GGACcAAGGGGGuAGAAGGdTsdT antis 1911-1930
5377 CUUCUACCCCCUUGGUCCC 5378 cuucuAcccccuuGGucccdTsdT sense
1911-1930 5379 GGGACCAAGGGGGUAGAAG 5380 GGGACcAAGGGGGuAGAAGdTsdT
antis 1932-1951 5381 CCCCUCCCCCAGGCUACCA 5382
ccccucccccAGGcuAccAdTsdT sense 1932-1951 5383 UGGUAGCCUGGGGGAGGGG
5384 UGGuAGCCUGGGGGAGGGGdTsdT antis 1942-1961 5385
AGGCUACCACUCCUUCCCU 5386 AGGcuAccAcuccuucccudTsdT sense 1942-1961
5387 AGGGAAGGAGUGGUAGCCU 5388 AGGGAAGGAGUGGuAGCCUdTsdT antis
1943-1962 5389 GGCUACCACUCCUUCCCUC 5390 GGcuAccAcuccuucccucdTsdT
sense 1943-1962 5391 GAGGGAAGGAGUGGUAGCC 5392
GAGGGAAGGAGUGGuAGCCdTsdT antis 1958-1977 5393 CCUCCCCCCCUCUCCCAGG
5394 ccucccccccucucccAGGdTsdT sense 1958-1977 5395
CCUGGGAGAGGGGGGGAGG 5396 CCUGGGAGAGGGGGGGAGGdTsdT antis 1961-1980
5397 CCCCCCCUCUCCCAGGUCC 5398 cccccccucucccAGGuccdTsdT sense
1961-1980 5399 GGACCUGGGAGAGGGGGGG 5400 GGACCUGGGAGAGGGGGGGdTsdT
antis 1966-1985 5401 CCUCUCCCAGGUCCCUUGU 5402
ccucucccAGGucccuuGudTsdT sense 1966-1985 5403 ACAAGGGACCUGGGAGAGG
5404 AcAAGGGACCUGGGAGAGGdTsdT antis 1972-1991 5405
CCAGGUCCCUUGUAAAUAG 5406 ccAGGucccuuGuAAAuAGdTsdT sense 1972-1991
5407 CUAUUUACAAGGGACCUGG 5408 CuAUUuAcAAGGGACCUGGdTsdT antis
1989-2008 5409 AGAACCAGCCCAGCCCAUC 5410 AGAAccAGcccAGcccAucdTsdT
sense 1989-2008 5411 GAUGGGCUGGGCUGGUUCU 5412
GAUGGGCUGGGCUGGUUCUdTsdT antis 1990-2009 5413 GAACCAGCCCAGCCCAUCU
5414 GAAccAGcccAGcccAucudTsdT sense 1990-2009 5415
AGAUGGGCUGGGCUGGUUC 5416 AGAUGGGCUGGGCUGGUUCdTsdT antis 1991-2010
5417 AACCAGCCCAGCCCAUCUC 5418 AAccAGcccAGcccAucucdTsdT sense
1991-2010 5419 GAGAUGGGCUGGGCUGGUU 5420 GAGAUGGGCUGGGCUGGUUdTsdT
antis 1992-2011 5421 ACCAGCCCAGCCCAUCUCU 5422
AccAGcccAGcccAucucudTsdT sense 1992-2011 5423 AGAGAUGGGCUGGGCUGGU
5424 AGAGAUGGGCUGGGCUGGUdTsdT antis 1993-2012 5425
CCAGCCCAGCCCAUCUCUC 5426 ccAGcccAGcccAucucucdTsdT sense 1993-2012
5427 GAGAGAUGGGCUGGGCUGG 5428 GAGAGAUGGGCUGGGCUGGdTsdT antis
2007-2026 5429 CUCUCGUCUUCCCUUCCCU 5430 cucucGucuucccuucccudTsdT
sense 2007-2026 5431 AGGGAAGGGAAGACGAGAG 5432
AGGGAAGGGAAGACGAGAGdTsdT antis 2008-2027 5433 UCUCGUCUUCCCUUCCCUG
5434 ucucGucuucccuucccuGdTsdT sense 2008-2027 5435
CAGGGAAGGGAAGACGAGA 5436 cAGGGAAGGGAAGACGAGAdTsdT antis 2013-2032
5437 UCUUCCCUUCCCUGGCCCC 5438 ucuucccuucccuGGccccdTsdT sense
2013-2032 5439 GGGGCCAGGGAAGGGAAGA 5440 GGGGCcAGGGAAGGGAAGAdTsdT
antis 2074-2033 5441 CUUCCCUUCCCUGGCCCCC 5442
cuucccuucccuGGcccccdTsdT sense 2074-2033 5443 GGGGGCCAGGGAAGGGAAG
5444 GGGGGCcAGGGAAGGGAAGdTsdT antis 2021-2040 5445
UCCCUGGCCCCCUGGGUGU 5446 ucccuGGcccccuGGGuGudTsdT sense 2021-2040
5447 ACACCCAGGGGGCCAGGGA 5448 AcACCcAGGGGGCcAGGGAdTsdT antis
2038-2057 5449 GUAAAUAGAUUGUUAUAAU 5450 GuAAAuAGAuuGuuAuAAudTsdT
sense 2038-2057 5451 AUUAUAACAAUCUAUUUAC 5452
AUuAuAAcAAUCuAUUuACdTsdT antis 2048-2067 5453 UGUUAUAAUUUUUUCUUAA
5454 uGuuAuAAuuuuuucuuAAdTsdT sense 2048-2067 5455
UUAAGAAAAAAUUAUAACA 5456 UuAAGAAAAAAUuAuAAcAdTsdT antis 2106-2125
5457 GCUGUACCCCUUCUUGUCC 5458 GcuGuAccccuucuuGuccdTsdT sense
2106-2125 5459 GGACAAGAAGGGGUACAGC 5460 GGAcAAGAAGGGGuAcAGCdTsdT
antis 2109-2128 5461 GUACCCCUUCUUGUCCUCU 5462
GuAccccuucuuGuccucudTsdT sense 2109-2128 5463 AGAGGACAAGAAGGGGUAC
5464 AGAGGAcAAGAAGGGGuACdTsdT antis 2120-2139 5465
UGUCCUCUGCUCCCAAGGC 5466 uGuccucuGcucccAAGGcdTsdT sense 2120-2139
5467 GCCUUGGGAGCAGAGGACA 5468 GCCUUGGGAGcAGAGGAcAdTsdT antis
2170-2189 5469 AGUAGAGAGAGUCCCUGGU 5470 AGuAGAGAGAGucccuGGudTsdT
sense 2170-2189 5471 ACCAGGGACUCUCUCUACU 5472
ACcAGGGACUCUCUCuACUdTsdT antis 2180-2199 5473 GUCCCUGGUGUCUUAGUUU
5474 GucccuGGuGucuuAGuuudTsdT sense 2180-2199 5475
AAACUAAGACACCAGGGAC 5476 AAACuAAGAcACcAGGGACdTsdT antis 2187-2206
5477 GUGUCUUAGUUUCCACAGU 5478 GuGucuuAGuuuccAcAGudTsdT sense
2187-2206 5479 ACUGUGGAAACUAAGACAC 5480 ACUGUGGAAACuAAGAcACdTsdT
antis 2189-2208 5481 GUCUUAGUUUCCACAGUAA 5482
GucuuAGuuuccAcAGuAAdTsdT sense 2189-2208 5483 UUACUGUGGAAACUAAGAC
5484 UuACUGUGGAAACuAAGACdTsdT antis 2190-2209 5485
UCUUAGUUUCCACAGUAAG 5486 ucuuAGuuuccAcAGuAAGdTsdT sense 2190-2209
5487 CUUACUGUGGAAACUAAGA 5488 CUuACUGUGGAAACuAAGAdTsdT antis
2225-2244 5489 ACCUCUGUUCAAUAAAUUA 5490 AccucuGuucAAuAAAuuAdTsdT
sense 2225-2244 5491 UAAUUUAUUGAACAGAGGU 5492
uAAUUuAUUGAAcAGAGGUdTsdT antis 2238-2257 5493 AAAUUAUUGGCAUGAAACC
5494 AAAuuAuuGGcAuGAAAccdTsdT sense 2238-2257 5495
GGUUUCAUGCCAAUAAUUU 5496 GGUUUcAUGCcAAuAAUUUdTsdT antis 2239-2258
5497 AAUUAUUGGCAUGAAACCC 5498 AAuuAuuGGcAuGAAAcccdTsdT sense
2239-2258 5499 GGGUUUCAUGCCAAUAAUU 5500 GGGUUUcAUGCcAAuAAUUdTsdT
antis 2241-2260 5501 UUAUUGGCAUGAAACCCUU 5502
uuAuuGGcAuGAAAcccuudTsdT sense 2241-2260 5503 AAGGGUUUCAUGCCAAUAA
5504 AAGGGUUUcAUGCcAAuAAdTsdT antis 34-53 5505 CAUCUCCCGGCGUGCCCCG
5506 cAucucccGGcGuGccccGdTsdT sense 34-53 5507 CGGGGCACGCCGGGAGAUG
5508 CGGGGcACGCCGGGAGAUGdTsdT antis 35-54 5509 AUCUCCCGGCGUGCCCCGC
5510 AucucccGGcGuGccccGcdTsdT sense
35-54 5511 GCGGGGCACGCCGGGAGAU 5512 GCGGGGcACGCCGGGAGAUdTsdT antis
97-116 5513 GAAGAGGCCGGAGCCCAGG 5514 GAAGAGGccGGAGcccAGGdTsdT sense
97-116 5515 CCUGGGCUCCGGCCUCUUC 5516 CCUGGGCUCCGGCCUCUUCdTsdT antis
163-182 5517 CCCCGCGGCCUGGGCCUGC 5518 ccccGcGGccuGGGccuGcdTsdT
sense 163-182 5519 GCAGGCCCAGGCCGCGGGG 5520
GcAGGCCcAGGCCGCGGGGdTsdT antis 164-183 5521 CCCGCGGCCUGGGCCUGCG
5522 cccGcGGccuGGGccuGcGdTsdT sense 164-183 5523
CGCAGGCCCAGGCCGCGGG 5524 CGcAGGCCcAGGCCGCGGGdTsdT antis 228-247
5525 GGCUCGGGCCGGGCGCGGA 5526 GGcucGGGccGGGcGcGGAdTsdT sense
228-247 5527 UCCGCGCCCGGCCCGAGCC 5528 UCCGCGCCCGGCCCGAGCCdTsdT
antis 235-254 5529 GCCGGGCGCGGACCAGCUC 5530
GccGGGcGcGGAccAGcucdTsdT sense 235-254 5531 GAGCUGGUCCGCGCCCGGC
5532 GAGCUGGUCCGCGCCCGGCdTsdT antis 247-266 5533
CCAGCUCGUUCGCGGAGCC 5534 ccAGcucGuucGcGGAGccdTsdT sense 247-266
5535 GGCUCCGCGAACGAGCUGG 5536 GGCUCCGCGAACGAGCUGGdTsdT antis
262-281 5537 AGCCAGGAGGCGGAGGCGG 5538 AGccAGGAGGcGGAGGcGGdTsdT
sense 262-281 5539 CCGCCUCCGCCUCCUGGCU 5540
CCGCCUCCGCCUCCUGGCUdTsdT antis 301-320 5541 GGGGCUCGGCCUCUGGCCC
5542 GGGGcucGGccucuGGcccdTsdT sense 301-320 5543
GGGCCAGAGGCCGAGCCCC 5544 GGGCcAGAGGCCGAGCCCCdTsdT antis 393-412
5545 GGCCCCAGCGGCAGCGGCG 5546 GGccccAGcGGcAGcGGcGdTsdT sense
393-412 5547 CGCCGCUGCCGCUGGGGCC 5548 CGCCGCUGCCGCUGGGGCCdTsdT
antis 403-422 5549 GCAGCGGCGGAGGAGGCAG 5550
GcAGcGGcGGAGGAGGcAGdTsdT sense 403-422 5551 CUGCCUCCUCCGCCGCUGC
5552 CUGCCUCCUCCGCCGCUGCdTsdT antis 420-439 5553
AGCGGUGGCCCCGGCGCGG 5554 AGcGGuGGccccGGcGcGGdTsdT sense 420-439
5555 CCGCGCCGGGGCCACCGCU 5556 CCGCGCCGGGGCcACCGCUdTsdT antis
502-521 5557 UAGCCACUGUAGGCCAAGG 5558 uAGccAcuGuAGGccAAGGdTsdT
sense 502-521 5559 CCUUGGCCUACAGUGGCUA 5560
CCUUGGCCuAcAGUGGCuAdTsdT antis 531-550 5561 UCCCAAGAAGUGGCUUACA
5562 ucccAAGAAGuGGcuuAcAdTsdT sense 531-550 5563
UGUAAGCCACUUCUUGGGA 5564 UGuAAGCcACUUCUUGGGAdTsdT antis 665-684
5565 CCGAGAACUGCAGAUUAUG 5566 ccGAGAAcuGcAGAuuAuGdTsdT sense
665-684 5567 CAUAAUCUGCAGUUCUCGG 5568 cAuAAUCUGcAGUUCUCGGdTsdT
antis 1148-1167 5569 CUUCCCUGGGGACAGUGGG 5570
cuucccuGGGGAcAGuGGGdTsdT sense 1148-1167 5571 CCCACUGUCCCCAGGGAAG
5572 CCcACUGUCCCcAGGGAAGdTsdT antis 1356-1375 5573
CCAUCCUCAAGGCUCUCCC 5574 ccAuccucAAGGcucucccdTsdT sense 1356-1375
5575 GGGAGAGCCUUGAGGAUGG 5576 GGGAGAGCCUUGAGGAUGGdTsdT antis
1358-1377 5577 AUCCUCAAGGCUCUCCCCA 5578 AuccucAAGGcucuccccAdTsdT
sense 1358-1377 5579 UGGGGAGAGCCUUGAGGAU 5580
UGGGGAGAGCCUUGAGGAUdTsdT antis 1485-1504 5581 UCCAUCCAACCAUCUCUCA
5582 uccAuccAAccAucucucAdTsdT sense 1485-1504 5583
UGAGAGAUGGUUGGAUGGA 5584 UGAGAGAUGGUUGGAUGGAdTsdT antis 1620-1639
5585 CAGCCAUCUGAUGCCACAA 5586 cAGccAucuGAuGccAcAAdTsdT sense
1620-1639 5587 UUGUGGCAUCAGAUGGCUG 5588 UUGUGGcAUcAGAUGGCUGdTsdT
antis 1813-1832 5589 UCAGCAGCCUAACCUCUGU 5590
ucAGcAGccuAAccucuGudTsdT sense 1813-1832 5591 ACAGAGGUUAGGCUGCUGA
5592 AcAGAGGUuAGGCUGCUGAdTsdT antis 1954-1973 5593
CUUCCCUCCCCCCCUCUCC 5594 cuucccucccccccucuccdTsdT sense 1954-1973
5595 GGAGAGGGGGGGAGGGAAG 5596 GGAGAGGGGGGGAGGGAAGdTsdT antis
1957-1976 5597 CCCUCCCCCCCUCUCCCAG 5598 cccucccccccucucccAGdTsdT
sense 1957-1976 5599 CUGGGAGAGGGGGGGAGGG 5600
CUGGGAGAGGGGGGGAGGGdTsdT antis 2103-2122 5601 CCAGCUGUACCCCUUCUUG
5602 ccAGcuGuAccccuucuuGdTsdT sense 2103-2122 5603
CAAGAAGGGGUACAGCUGG 5604 cAAGAAGGGGuAcAGCUGGdTsdT antis 2119-2138
5605 UUGUCCUCUGCUCCCAAGG 5606 uuGuccucuGcucccAAGGdTsdT sense
2119-2138 5607 CCUUGGGAGCAGAGGACAA 5608 CCUUGGGAGcAGAGGAcAAdTsdT
antis 2122-2141 5609 UCCUCUGCUCCCAAGGCUU 5610
uccucuGcucccAAGGcuudTsdT sense 2122-2141 5611 AAGCCUUGGGAGCAGAGGA
5612 AAGCCUUGGGAGcAGAGGAdTsdT antis 2125-2144 5613
UCUGCUCCCAAGGCUUCCU 5614 ucuGcucccAAGGcuuccudTsdT sense 2125-2144
5615 AGGAAGCCUUGGGAGCAGA 5616 AGGAAGCCUUGGGAGcAGAdTsdT antis
2154-2173 5617 AUCCUGGAAGGAGGGGAGU 5618 AuccuGGAAGGAGGGGAGudTsdT
sense 2154-2173 5619 ACUCCCCUCCUUCCAGGAU 5620
ACUCCCCUCCUUCcAGGAUdTsdT antis 33-52 5621 UCAUCUCCCGGCGUGCCCC 5622
ucAucucccGGcGuGccccdTsdT sense 33-52 5623 GGGGCACGCCGGGAGAUGA 5624
GGGGcACGCCGGGAGAUGAdTsdT antis 46-65 5625 UGCCCCGCGGCGGGCGCUG 5626
uGccccGcGGcGGGcGcuGdTsdT sense 46-65 5627 CAGCGCCCGCCGCGGGGCA 5628
cAGCGCCCGCCGCGGGGcAdTsdT antis 47-66 5629 GCCCCGCGGCGGGCGCUGG 5630
GccccGcGGcGGGcGcuGGdTsdT sense 47-66 5631 CCAGCGCCCGCCGCGGGGC 5632
CcAGCGCCCGCCGCGGGGCdTsdT antis 53-72 5633 CGGCGGGCGCUGGGCCGGA 5634
cGGcGGGcGcuGGGccGGAdTsdT sense 53-72 5635 UCCGGCCCAGCGCCCGCCG 5636
UCCGGCCcAGCGCCCGCCGdTsdT antis 54-73 5637 GGCGGGCGCUGGGCCGGAG 5638
GGcGGGcGcuGGGccGGAGdTsdT sense 54-73 5639 CUCCGGCCCAGCGCCCGCC 5640
CUCCGGCCcAGCGCCCGCCdTsdT antis 55-74 5641 GCGGGCGCUGGGCCGGAGC 5642
GcGGGcGcuGGGccGGAGcdTsdT sense 55-74 5643 GCUCCGGCCCAGCGCCCGC 5644
GCUCCGGCCcAGCGCCCGCdTsdT antis 61-80 5645 GCUGGGCCGGAGCCGGAGC 5646
GcuGGGccGGAGccGGAGcdTsdT sense 61-80 5647 GCUCCGGCUCCGGCCCAGC 5648
GCUCCGGCUCCGGCCcAGCdTsdT antis 64-83 5649 GGGCCGGAGCCGGAGCCCG 5650
GGGccGGAGccGGAGcccGdTsdT sense 64-83 5651 CGGGCUCCGGCUCCGGCCC 5652
CGGGCUCCGGCUCCGGCCCdTsdT antis 67-86 5653 CCGGAGCCGGAGCCCGAAC 5654
ccGGAGccGGAGcccGAAcdTsdT sense 67-86 5655 GUUCGGGCUCCGGCUCCGG 5656
GUUCGGGCUCCGGCUCCGGdTsdT antis 92-111 5657 GCCUGGAAGAGGCCGGAGC 5658
GccuGGAAGAGGccGGAGcdTsdT sense 92-111 5659 GCUCCGGCCUCUUCCAGGC 5660
GCUCCGGCCUCUUCcAGGCdTsdT antis 93-112 5661 CCUGGAAGAGGCCGGAGCC 5662
ccuGGAAGAGGccGGAGccdTsdT sense 93-112 5663 GGCUCCGGCCUCUUCCAGG 5664
GGCUCCGGCCUCUUCcAGGdTsdT antis 101-120 5665 AGGCCGGAGCCCAGGGGAG
5666 AGGccGGAGcccAGGGGAGdTsdT sense 101-120 5667
CUCCCCUGGGCUCCGGCCU 5668 CUCCCCUGGGCUCCGGCCUdTsdT antis 102-121
5669 GGCCGGAGCCCAGGGGAGG 5670 GGccGGAGcccAGGGGAGGdTsdT sense
102-121 5671 CCUCCCCUGGGCUCCGGCC 5672 CCUCCCCUGGGCUCCGGCCdTsdT
antis 106-125 5673 GGAGCCCAGGGGAGGCGGC 5674
GGAGcccAGGGGAGGcGGcdTsdT sense 106-125 5675 GCCGCCUCCCCUGGGCUCC
5676 GCCGCCUCCCCUGGGCUCCdTsdT antis 110-129 5677
CCCAGGGGAGGCGGCGGCA 5678 cccAGGGGAGGcGGcGGcAdTsdT sense 110-129
5679 UGCCGCCGCCUCCCCUGGG 5680 UGCCGCCGCCUCCCCUGGGdTsdT antis
111-130 5681 CCAGGGGAGGCGGCGGCAG 5682 ccAGGGGAGGcGGcGGcAGdTsdT
sense 111-130 5683 CUGCCGCCGCCUCCCCUGG 5684
CUGCCGCCGCCUCCCCUGGdTsdT antis 122-141 5685 GGCGGCAGAGGCAGCGGCG
5686 GGcGGcAGAGGcAGcGGcGdTsdT sense 122-141 5687
CGCCGCUGCCUCUGCCGCC 5688 CGCCGCUGCCUCUGCCGCCdTsdT antis 123-142
5689 GCGGCAGAGGCAGCGGCGG 5690 GcGGcAGAGGcAGcGGcGGdTsdT sense
123-142 5691 CCGCCGCUGCCUCUGCCGC 5692 CCGCCGCUGCCUCUGCCGCdTsdT
antis 124-143 5693 CGGCAGAGGCAGCGGCGGG 5694
cGGcAGAGGcAGcGGcGGGdTsdT sense 124-143 5695 CCCGCCGCUGCCUCUGCCG
5696 CCCGCCGCUGCCUCUGCCGdTsdT antis 125-144 5697
GGCAGAGGCAGCGGCGGGG 5698 GGcAGAGGcAGcGGcGGGGdTsdT sense 125-144
5699 CCCCGCCGCUGCCUCUGCC 5700 CCCCGCCGCUGCCUCUGCCdTsdT antis
132-151 5701 GCAGCGGCGGGGGCAGCCC 5702 GcAGcGGcGGGGGcAGcccdTsdT
sense 132-151 5703 GGGCUGCCCCCGCCGCUGC 5704
GGGCUGCCCCCGCCGCUGCdTsdT antis 139-158 5705 CGGGGGCAGCCCAGGCAGC
5706 cGGGGGcAGcccAGGcAGcdTsdT sense 139-158 5707
GCUGCCUGGGCUGCCCCCG 5708 GCUGCCUGGGCUGCCCCCGdTsdT antis 143-162
5709 GGCAGCCCAGGCAGCCCGA 5710 GGcAGcccAGGcAGcccGAdTsdT sense
143-162 5711 UCGGGCUGCCUGGGCUGCC 5712 UCGGGCUGCCUGGGCUGCCdTsdT
antis 146-165 5713 AGCCCAGGCAGCCCGAGCC 5714
AGcccAGGcAGcccGAGccdTsdT sense 146-165 5715 GGCUCGGGCUGCCUGGGCU
5716 GGCUCGGGCUGCCUGGGCUdTsdT antis 152-171 5717
GGCAGCCCGAGCCCCGCGG 5718 GGcAGcccGAGccccGcGGdTsdT sense 152-171
5719 CCGCGGGGCUCGGGCUGCC 5720 CCGCGGGGCUCGGGCUGCCdTsdT antis
154-173 5721 CAGCCCGAGCCCCGCGGCC 5722 cAGcccGAGccccGcGGccdTsdT
sense 154-173 5723 GGCCGCGGGGCUCGGGCUG 5724
GGCCGCGGGGCUCGGGCUGdTsdT antis 155-174 5725 AGCCCGAGCCCCGCGGCCU
5726 AGcccGAGccccGcGGccudTsdT sense 155-174 5727
AGGCCGCGGGGCUCGGGCU 5728 AGGCCGCGGGGCUCGGGCUdTsdT antis 156-175
5729 GCCCGAGCCCCGCGGCCUG 5730 GcccGAGccccGcGGccuGdTsdT sense
156-175 5731 CAGGCCGCGGGGCUCGGGC 5732 cAGGCCGCGGGGCUCGGGCdTsdT
antis 159-178 5733 CGAGCCCCGCGGCCUGGGC 5734
cGAGccccGcGGccuGGGcdTsdT sense 159-178 5735 GCCCAGGCCGCGGGGCUCG
5736 GCCcAGGCCGCGGGGCUCGdTsdT antis 160-179 5737
GAGCCCCGCGGCCUGGGCC 5738 GAGccccGcGGccuGGGccdTsdT sense 160-179
5739 GGCCCAGGCCGCGGGGCUC 5740 GGCCcAGGCCGCGGGGCUCdTsdT antis
161-180 5741 AGCCCCGCGGCCUGGGCCU 5742 AGccccGcGGccuGGGccudTsdT
sense 161-180 5743 AGGCCCAGGCCGCGGGGCU 5744
AGGCCcAGGCCGCGGGGCUdTsdT antis 162-181 5745 GCCCCGCGGCCUGGGCCUG
5746 GccccGcGGccuGGGccuGdTsdT sense 162-181 5747
CAGGCCCAGGCCGCGGGGC 5748 cAGGCCcAGGCCGCGGGGCdTsdT antis 174-193
5749 GGGCCUGCGCUCGGCGCCA 5750 GGGccuGcGcucGGcGccAdTsdT sense
174-193 5751 UGGCGCCGAGCGCAGGCCC 5752 UGGCGCCGAGCGcAGGCCCdTsdT
antis 210-229 5753 UCGGGAGGCGGCCCUGGGG 5754
ucGGGAGGcGGcccuGGGGdTsdT sense 210-229 5755 CCCCAGGGCCGCCUCCCGA
5756 CCCcAGGGCCGCCUCCCGAdTsdT antis 211-230 5757
CGGGAGGCGGCCCUGGGGG 5758 cGGGAGGcGGcccuGGGGGdTsdT sense 211-230
5759 CCCCCAGGGCCGCCUCCCG 5760 CCCCcAGGGCCGCCUCCCGdTsdT antis
212-231 5761 GGGAGGCGGCCCUGGGGGC 5762 GGGAGGcGGcccuGGGGGcdTsdT
sense 212-231 5763 GCCCCCAGGGCCGCCUCCC 5764
GCCCCcAGGGCCGCCUCCCdTsdT antis 217-236 5765 GCGGCCCUGGGGGCUCGGG
5766 GcGGcccuGGGGGcucGGGdTsdT sense 217-236 5767
CCCGAGCCCCCAGGGCCGC 5768 CCCGAGCCCCcAGGGCCGCdTsdT antis 218-237
5769 CGGCCCUGGGGGCUCGGGC 5770 cGGcccuGGGGGcucGGGcdTsdT sense
218-237 5771 GCCCGAGCCCCCAGGGCCG 5772 GCCCGAGCCCCcAGGGCCGdTsdT
antis 225-244 5773 GGGGGCUCGGGCCGGGCGC 5774
GGGGGcucGGGccGGGcGcdTsdT sense 225-244 5775 GCGCCCGGCCCGAGCCCCC
5776 GCGCCCGGCCCGAGCCCCCdTsdT antis 226-245 5777
GGGGCUCGGGCCGGGCGCG 5778 GGGGcucGGGccGGGcGcGdTsdT sense 226-245
5779 CGCGCCCGGCCCGAGCCCC 5780 CGCGCCCGGCCCGAGCCCCdTsdT antis
232-251 5781 CGGGCCGGGCGCGGACCAG 5782 cGGGccGGGcGcGGAccAGdTsdT
sense 232-251 5783 CUGGUCCGCGCCCGGCCCG 5784
CUGGUCCGCGCCCGGCCCGdTsdT antis 260-279 5785 GGAGCCAGGAGGCGGAGGC
5786 GGAGccAGGAGGcGGAGGcdTsdT sense 260-279 5787
GCCUCCGCCUCCUGGCUCC 5788 GCCUCCGCCUCCUGGCUCCdTsdT antis 263-282
5789 GCCAGGAGGCGGAGGCGGA 5790 GccAGGAGGcGGAGGcGGAdTsdT sense
263-282 5791 UCCGCCUCCGCCUCCUGGC 5792 UCCGCCUCCGCCUCCUGGCdTsdT
antis 264-283 5793 CCAGGAGGCGGAGGCGGAG 5794
ccAGGAGGcGGAGGcGGAGdTsdT sense 264-283 5795 CUCCGCCUCCGCCUCCUGG
5796 CUCCGCCUCCGCCUCCUGGdTsdT antis 270-289 5797
GGCGGAGGCGGAGGUGGUG 5798 GGcGGAGGcGGAGGuGGuGdTsdT sense 270-289
5799 CACCACCUCCGCCUCCGCC 5800 cACcACCUCCGCCUCCGCCdTsdT antis
280-299 5801 GAGGUGGUGGCGGCGGCCC 5802 GAGGuGGuGGcGGcGGcccdTsdT
sense 280-299 5803 GGGCCGCCGCCACCACCUC 5804
GGGCCGCCGCcACcACCUCdTsdT antis 281-300 5805 AGGUGGUGGCGGCGGCCCC
5806 AGGuGGuGGcGGcGGccccdTsdT sense 281-300 5807
GGGGCCGCCGCCACCACCU 5808 GGGGCCGCCGCcACcACCUdTsdT antis 282-301
5809 GGUGGUGGCGGCGGCCCCG 5810 GGuGGuGGcGGcGGccccGdTsdT sense
282-301 5811 CGGGGCCGCCGCCACCACC 5812 CGGGGCCGCCGCcACcACCdTsdT
antis 283-302 5813 GUGGUGGCGGCGGCCCCGG 5814
GuGGuGGcGGcGGccccGGdTsdT sense 283-302 5815 CCGGGGCCGCCGCCACCAC
5816 CCGGGGCCGCCGCcACcACdTsdT antis 289-308 5817
GCGGCGGCCCCGGGGGCUC 5818 GcGGcGGccccGGGGGcucdTsdT sense 289-308
5819 GAGCCCCCGGGGCCGCCGC 5820 GAGCCCCCGGGGCCGCCGCdTsdT antis
291-310 5821 GGCGGCCCCGGGGGCUCGG 5822 GGcGGccccGGGGGcucGGdTsdT
sense 291-310 5823 CCGAGCCCCCGGGGCCGCC 5824
CCGAGCCCCCGGGGCCGCCdTsdT antis 296-315 5825 CCCCGGGGGCUCGGCCUCU
5826 ccccGGGGGcucGGccucudTsdT sense 296-315 5827
AGAGGCCGAGCCCCCGGGG 5828 AGAGGCCGAGCCCCCGGGGdTsdT antis 303-322
5829 GGCUCGGCCUCUGGCCCAG 5830 GGcucGGccucuGGcccAGdTsdT sense
303-322 5831 CUGGGCCAGAGGCCGAGCC 5832 CUGGGCcAGAGGCCGAGCCdTsdT
antis 320-339 5833 AGGAGGCACUGGCGGCGGG 5834
AGGAGGcAcuGGcGGcGGGdTsdT sense 320-339 5835 CCCGCCGCCAGUGCCUCCU
5836 CCCGCCGCcAGUGCCUCCUdTsdT antis 382-401 5837
GCUCCGGGGGUGGCCCCAG 5838 GcuccGGGGGuGGccccAGdTsdT sense 382-401
5839 CUGGGGCCACCCCCGGAGC 5840 CUGGGGCcACCCCCGGAGCdTsdT antis
383-402 5841 CUCCGGGGGUGGCCCCAGC 5842 cuccGGGGGuGGccccAGcdTsdT
sense 383-402 5843 GCUGGGGCCACCCCCGGAG 5844
GCUGGGGCcACCCCCGGAGdTsdT antis 395-414 5845 CCCCAGCGGCAGCGGCGGA
5846 ccccAGcGGcAGcGGcGGAdTsdT sense 395-414 5847
UCCGCCGCUGCCGCUGGGG 5848 UCCGCCGCUGCCGCUGGGGdTsdT antis 396-415
5849 CCCAGCGGCAGCGGCGGAG 5850 cccAGcGGcAGcGGcGGAGdTsdT sense
396-415 5851 CUCCGCCGCUGCCGCUGGG 5852 CUCCGCCGCUGCCGCUGGGdTsdT
antis 397-416 5853 CCAGCGGCAGCGGCGGAGG 5854
ccAGcGGcAGcGGcGGAGGdTsdT sense 397-416 5855 CCUCCGCCGCUGCCGCUGG
5856 CCUCCGCCGCUGCCGCUGGdTsdT antis 398-417 5857
CAGCGGCAGCGGCGGAGGA 5858 cAGcGGcAGcGGcGGAGGAdTsdT sense 398-417
5859 UCCUCCGCCGCUGCCGCUG 5860 UCCUCCGCCGCUGCCGCUGdTsdT antis
400-419 5861 GCGGCAGCGGCGGAGGAGG 5862 GcGGcAGcGGcGGAGGAGGdTsdT
sense 400-419 5863 CCUCCUCCGCCGCUGCCGC 5864
CCUCCUCCGCCGCUGCCGCdTsdT antis 405-424 5865 AGCGGCGGAGGAGGCAGCG
5866 AGcGGcGGAGGAGGcAGcGdTsdT sense 405-424 5867
CGCUGCCUCCUCCGCCGCU 5868 CGCUGCCUCCUCCGCCGCUdTsdT antis 406-425
5869 GCGGCGGAGGAGGCAGCGG 5870 GcGGcGGAGGAGGcAGcGGdTsdT sense
406-425 5871 CCGCUGCCUCCUCCGCCGC 5872 CCGCUGCCUCCUCCGCCGCdTsdT
antis 407-426 5873 CGGCGGAGGAGGCAGCGGU 5874
cGGcGGAGGAGGcAGcGGudTsdT sense 407-426 5875 ACCGCUGCCUCCUCCGCCG
5876 ACCGCUGCCUCCUCCGCCGdTsdT antis 408-427 5877
GGCGGAGGAGGCAGCGGUG 5878 GGcGGAGGAGGcAGcGGuGdTsdT sense 408-427
5879 CACCGCUGCCUCCUCCGCC 5880 cACCGCUGCCUCCUCCGCCdTsdT antis
444-463 5881 AGCUUCCCGCCGCCGGGAG 5882 AGcuucccGccGccGGGAGdTsdT
sense 444-463 5883 CUCCCGGCGGCGGGAAGCU 5884
CUCCCGGCGGCGGGAAGCUdTsdT antis 461-480 5885 AGUGAAGCUGGGCCGUGAC
5886 AGuGAAGcuGGGccGuGAcdTsdT sense 461-480 5887
GUCACGGCCCAGCUUCACU 5888 GUcACGGCCcAGCUUcACUdTsdT antis 493-512
5889 CCACAGUGGUAGCCACUGU 5890 ccAcAGuGGuAGccAcuGudTsdT sense
493-512 5891 ACAGUGGCUACCACUGUGG 5892 AcAGUGGCuACcACUGUGGdTsdT
antis 513-532 5893 GGCCAAGGCCCAGAGCGUU 5894
GGccAAGGcccAGAGcGuudTsdT sense 513-532 5895 AACGCUCUGGGCCUUGGCC
5896 AACGCUCUGGGCCUUGGCCdTsdT antis 606-625 5897
GCAGAGACGAGGGAACUGG 5898 GcAGAGAcGAGGGAAcuGGdTsdT sense 606-625
5899 CCAGUUCCCUCGUCUCUGC 5900 CcAGUUCCCUCGUCUCUGCdTsdT antis
616-635 5901 GGGAACUGGUGGCCAUCAA 5902 GGGAAcuGGuGGccAucAAdTsdT
sense 616-635 5903 UUGAUGGCCACCAGUUCCC 5904
UUGAUGGCcACcAGUUCCCdTsdT antis 620-639 5905 ACUGGUGGCCAUCAAGAAG
5906 AcuGGuGGccAucAAGAAGdTsdT sense 620-639 5907
CUUCUUGAUGGCCACCAGU 5908 CUUCUUGAUGGCcACcAGUdTsdT antis 621-640
5909 CUGGUGGCCAUCAAGAAGG 5910 cuGGuGGccAucAAGAAGGdTsdT sense
621-640 5911 CCUUCUUGAUGGCCACCAG 5912 CCUUCUUGAUGGCcACcAGdTsdT
antis 711-730 5913 AGGCUGCGGUACUUUUUCU 5914
AGGcuGcGGuAcuuuuucudTsdT sense 711-730 5915 AGAAAAAGUACCGCAGCCU
5916 AGAAAAAGuACCGcAGCCUdTsdT antis 712-731 5917
GGCUGCGGUACUUUUUCUA 5918 GGcuGcGGuAcuuuuucuAdTsdT sense 712-731
5919 UAGAAAAAGUACCGCAGCC 5920 uAGAAAAAGuACCGcAGCCdTsdT antis
716-735 5921 GCGGUACUUUUUCUACUCC 5922 GcGGuAcuuuuucuAcuccdTsdT
sense 716-735 5923 GGAGUAGAAAAAGUACCGC 5924
GGAGuAGAAAAAGuACCGCdTsdT antis 851-870 5925 CAUCAAGGUGUACAUGUAC
5926 cAucAAGGuGuAcAuGuAcdTsdT sense 851-870 5927
GUACAUGUACACCUUGAUG 5928 GuAcAUGuAcACCUUGAUGdTsdT antis 891-910
5929 UACAUCCACUCCCAAGGUG 5930 uAcAuccAcucccAAGGuGdTsdT sense
891-910 5931 CACCUUGGGAGUGGAUGUA 5932 cACCUUGGGAGUGGAUGuAdTsdT
antis 948-967 5933 GACCCUGACACUGCUGUCC 5934
GAcccuGAcAcuGcuGuccdTsdT sense 948-967 5935 GGACAGCAGUGUCAGGGUC
5936 GGAcAGcAGUGUcAGGGUCdTsdT antis 951-970 5937
CCUGACACUGCUGUCCUCA 5938 ccuGAcAcuGcuGuccucAdTsdT sense 951-970
5939 UGAGGACAGCAGUGUCAGG 5940 UGAGGAcAGcAGUGUcAGGdTsdT antis
955-974 5941 ACACUGCUGUCCUCAAGCU 5942 AcAcuGcuGuccucAAGcudTsdT
sense 955-974 5943 AGCUUGAGGACAGCAGUGU 5944
AGCUUGAGGAcAGcAGUGUdTsdT antis 956-975 5945 CACUGCUGUCCUCAAGCUC
5946 cAcuGcuGuccucAAGcucdTsdT sense 956-975 5947
GAGCUUGAGGACAGCAGUG 5948 GAGCUUGAGGAcAGcAGUGdTsdT antis 958-977
5949 CUGCUGUCCUCAAGCUCUG 5950 cuGcuGuccucAAGcucuGdTsdT sense
958-977 5951 CAGAGCUUGAGGACAGCAG 5952 cAGAGCUUGAGGAcAGcAGdTsdT
antis 959-978 5953 UGCUGUCCUCAAGCUCUGC 5954
uGcuGuccucAAGcucuGcdTsdT sense 959-978 5955 GCAGAGCUUGAGGACAGCA
5956 GcAGAGCUUGAGGAcAGcAdTsdT antis 1028-1047 5957
CAUCUGCUCUCGGUACUAC 5958 cAucuGcucucGGuAcuAcdTsdT sense 1028-1047
5959 GUAGUACCGAGAGCAGAUG 5960 GuAGuACCGAGAGcAGAUGdTsdT antis
1052-1071 5961 UCCAGAACUCAUCUUUGGA 5962 uccAGAAcucAucuuuGGAdTsdT
sense 1052-1071 5963 UCCAAAGAUGAGUUCUGGA 5964
UCcAAAGAUGAGUUCUGGAdTsdT antis 1084-1103 5965 CCUCGUCCAUCGAUGUGUG
5966 ccucGuccAucGAuGuGuGdTsdT sense 1084-1103 5967
CACACAUCGAUGGACGAGG 5968 cAcAcAUCGAUGGACGAGGdTsdT antis 1103-1122
5969 GUCGGCUGGCUGUGUACUU 5970 GucGGcuGGcuGuGuAcuudTsdT sense
1103-1122 5971 AAGUACACAGCCAGCCGAC 5972 AAGuAcAcAGCcAGCCGACdTsdT
antis 1111-1130 5973 GCUGUGUACUUGCUGAGCU 5974
GcuGuGuAcuuGcuGAGcudTsdT sense 1111-1130 5975 AGCUCAGCAAGUACACAGC
5976 AGCUcAGcAAGuAcAcAGCdTsdT antis 1116-1135 5977
GUACUUGCUGAGCUACUUC 5978 GuAcuuGcuGAGcuAcuucdTsdT sense 1116-1135
5979 GAAGUAGCUCAGCAAGUAC 5980 GAAGuAGCUcAGcAAGuACdTsdT antis
1132-1151 5981 UUCUCGGCCAGCCCAUCUU 5982 uucucGGccAGcccAucuudTsdT
sense 1132-1151 5983 AAGAUGGGCUGGCCGAGAA 5984
AAGAUGGGCUGGCCGAGAAdTsdT antis 1133-1152 5985 UCUCGGCCAGCCCAUCUUC
5986 ucucGGccAGcccAucuucdTsdT sense 1133-1152 5987
GAAGAUGGGCUGGCCGAGA 5988 GAAGAUGGGCUGGCCGAGAdTsdT antis 1136-1155
5989 CGGCCAGCCCAUCUUCCCU 5990 cGGccAGcccAucuucccudTsdT sense
1136-1155 5991 AGGGAAGAUGGGCUGGCCG 5992 AGGGAAGAUGGGCUGGCCGdTsdT
antis 1143-1162 5993 CCCAUCUUCCCUGGGGACA 5994
cccAucuucccuGGGGAcAdTsdT sense 1143-1162 5995 UGUCCCCAGGGAAGAUGGG
5996 UGUCCCcAGGGAAGAUGGGdTsdT antis 1147-1166 5997
UCUUCCCUGGGGACAGUGG 5998 ucuucccuGGGGAcAGuGGdTsdT sense 1147-1166
5999 CCACUGUCCCCAGGGAAGA 6000 CcACUGUCCCcAGGGAAGAdTsdT antis
1152-1171 6001 CCUGGGGACAGUGGGGUGG 6002 ccuGGGGAcAGuGGGGuGGdTsdT
sense 1152-1171 6003 CCACCCCACUGUCCCCAGG 6004
CcACCCcACUGUCCCcAGGdTsdT antis 1161-1180 6005 AGUGGGGUGGACCAGCUUG
6006 AGuGGGGuGGAccAGcuuGdTsdT sense 1161-1180 6007
CAAGCUGGUCCACCCCACU 6008 cAAGCUGGUCcACCCcACUdTsdT antis 1277-1296
6009 CCCUUGGACAAAGGUGUUC 6010 cccuuGGAcAAAGGuGuucdTsdT sense
1277-1296 6011 GAACACCUUUGUCCAAGGG 6012 GAAcACCUUUGUCcAAGGGdTsdT
antis
1298-1317 6013 AUCUUCAAAGACACCACCU 6014 AucuucAAAGAcAccAccudTsdT
sense 1298-1317 6015 AGGUGGUGUCUUUGAAGAU 6016
AGGUGGUGUCUUUGAAGAUdTsdT antis 1300-1319 6017 CUUCAAAGACACCACCUGA
6018 cuucAAAGAcAccAccuGAdTsdT sense 1300-1319 6019
UCAGGUGGUGUCUUUGAAG 6020 UcAGGUGGUGUCUUUGAAGdTsdT antis 1301-1320
6021 UUCAAAGACACCACCUGAG 6022 uucAAAGAcAccAccuGAGdTsdT sense
1301-1320 6023 CUCAGGUGGUGUCUUUGAA 6024 CUcAGGUGGUGUCUUUGAAdTsdT
antis 1357-1376 6025 CAUCCUCAAGGCUCUCCCC 6026
cAuccucAAGGcucuccccdTsdT sense 1357-1376 6027 GGGGAGAGCCUUGAGGAUG
6028 GGGGAGAGCCUUGAGGAUGdTsdT antis 1390-1409 6029
CCCACAGCUUCUUCGAUGA 6030 cccAcAGcuucuucGAuGAdTsdT sense 1390-1409
6031 UCAUCGAAGAAGCUGUGGG 6032 UcAUCGAAGAAGCUGUGGGdTsdT antis
1419-1438 6033 CUCGGAGCCCAGCUCCCCA 6034 cucGGAGcccAGcuccccAdTsdT
sense 1419-1438 6035 UGGGGAGCUGGGCUCCGAG 6036
UGGGGAGCUGGGCUCCGAGdTsdT antis 1421-1440 6037 CGGAGCCCAGCUCCCCAAC
6038 cGGAGcccAGcuccccAAcdTsdT sense 1421-1440 6039
GUUGGGGAGCUGGGCUCCG 6040 GUUGGGGAGCUGGGCUCCGdTsdT antis 1497-1516
6041 UCUCUCAAUGCCAUUCUCA 6042 ucucucAAuGccAuucucAdTsdT sense
1497-1516 6043 UGAGAAUGGCAUUGAGAGA 6044 UGAGAAUGGcAUUGAGAGAdTsdT
antis 1500-1519 6045 CUCAAUGCCAUUCUCAUCC 6046
cucAAuGccAuucucAuccdTsdT sense 1500-1519 6047 GGAUGAGAAUGGCAUUGAG
6048 GGAUGAGAAUGGcAUUGAGdTsdT antis 1501-1520 6049
UCAAUGCCAUUCUCAUCCC 6050 ucAAuGccAuucucAucccdTsdT sense 1501-1520
6051 GGGAUGAGAAUGGCAUUGA 6052 GGGAUGAGAAUGGcAUUGAdTsdT antis
1540-1559 6053 CAGGCCCUGCUUCUCCCCU 6054 cAGGcccuGcuucuccccudTsdT
sense 1540-1559 6055 AGGGGAGAAGCAGGGCCUG 6056
AGGGGAGAAGcAGGGCCUGdTsdT antis 1547-1566 6057 UGCUUCUCCCCUCACCACU
6058 uGcuucuccccucAccAcudTsdT sense 1547-1566 6059
AGUGGUGAGGGGAGAAGCA 6060 AGUGGUGAGGGGAGAAGcAdTsdT antis 1586-1605
6061 AGCUUUAACUGAAGCUCAG 6062 AGcuuuAAcuGAAGcucAGdTsdT sense
1586-1605 6063 CUGAGCUUCAGUUAAAGCU 6064 CUGAGCUUcAGUuAAAGCUdTsdT
antis 1621-1640 6065 AGCCAUCUGAUGCCACAAC 6066
AGccAucuGAuGccAcAAcdTsdT sense 1621-1640 6067 GUUGUGGCAUCAGAUGGCU
6068 GUUGUGGcAUcAGAUGGCUdTsdT antis 1818-1837 6069
AGCCUAACCUCUGUGGUGG 6070 AGccuAAccucuGuGGuGGdTsdT sense 1818-1837
6071 CCACCACAGAGGUUAGGCU 6072 CcACcAcAGAGGUuAGGCUdTsdT antis
1865-1884 6073 UAGGGGAGGGGAGAAAAGG 6074 uAGGGGAGGGGAGAAAAGGdTsdT
sense 1865-1884 6075 CCUUUUCUCCCCUCCCCUA 6076
CCUUUUCUCCCCUCCCCuAdTsdT antis 1866-1885 6077 AGGGGAGGGGAGAAAAGGA
6078 AGGGGAGGGGAGAAAAGGAdTsdT sense 1866-1885 6079
UCCUUUUCUCCCCUCCCCU 6080 UCCUUUUCUCCCCUCCCCUdTsdT antis 1867-1886
6081 GGGGAGGGGAGAAAAGGAA 6082 GGGGAGGGGAGAAAAGGAAdTsdT sense
1867-1886 6083 UUCCUUUUCUCCCCUCCCC 6084 UUCCUUUUCUCCCCUCCCCdTsdT
antis 1868-1887 6085 GGGAGGGGAGAAAAGGAAG 6086
GGGAGGGGAGAAAAGGAAGdTsdT sense 1868-1887 6087 CUUCCUUUUCUCCCCUCCC
6088 CUUCCUUUUCUCCCCUCCCdTsdT antis 1872-1891 6089
GGGGAGAAAAGGAAGGACG 6090 GGGGAGAAAAGGAAGGAcGdTsdT sense 1872-1891
6091 CGUCCUUCCUUUUCUCCCC 6092 CGUCCUUCCUUUUCUCCCCdTsdT antis
1901-1920 6093 GUGUGAGGACCUUCUACCC 6094 GuGuGAGGAccuucuAcccdTsdT
sense 1901-1920 6095 GGGUAGAAGGUCCUCACAC 6096
GGGuAGAAGGUCCUcAcACdTsdT antis 1929-1948 6097 CCUCCCCUCCCCCAGGCUA
6098 ccuccccucccccAGGcuAdTsdT sense 1929-1948 6099
UAGCCUGGGGGAGGGGAGG 6100 uAGCCUGGGGGAGGGGAGGdTsdT antis 1930-1949
6101 CUCCCCUCCCCCAGGCUAC 6102 cuccccucccccAGGcuAcdTsdT sense
1930-1949 6103 GUAGCCUGGGGGAGGGGAG 6104 GuAGCCUGGGGGAGGGGAGdTsdT
antis 1947-1966 6105 ACCACUCCUUCCCUCCCCC 6106
AccAcuccuucccucccccdTsdT sense 1947-1966 6107 GGGGGAGGGAAGGAGUGGU
6108 GGGGGAGGGAAGGAGUGGUdTsdT antis 1948-1967 6109
CCACUCCUUCCCUCCCCCC 6110 ccAcuccuucccuccccccdTsdT sense 1948-1967
6111 GGGGGGAGGGAAGGAGUGG 6112 GGGGGGAGGGAAGGAGUGGdTsdT antis
1949-1968 6113 CACUCCUUCCCUCCCCCCC 6114 cAcuccuucccucccccccdTsdT
sense 1949-1968 6115 GGGGGGGAGGGAAGGAGUG 6116
GGGGGGGAGGGAAGGAGUGdTsdT antis 1950-1969 6117 ACUCCUUCCCUCCCCCCCU
6118 AcuccuucccucccccccudTsdT sense 1950-1969 6119
AGGGGGGGAGGGAAGGAGU 6120 AGGGGGGGAGGGAAGGAGUdTsdT antis 1951-1970
6121 CUCCUUCCCUCCCCCCCUC 6122 cuccuucccucccccccucdTsdT sense
1951-1970 6123 GAGGGGGGGAGGGAAGGAG 6124 GAGGGGGGGAGGGAAGGAGdTsdT
antis 1955-1974 6125 UUCCCUCCCCCCCUCUCCC 6126
uucccucccccccucucccdTsdT sense 1955-1974 6127 GGGAGAGGGGGGGAGGGAA
6128 GGGAGAGGGGGGGAGGGAAdTsdT antis 1956-1975 6129
UCCCUCCCCCCCUCUCCCA 6130 ucccucccccccucucccAdTsdT sense 1956-1975
6131 UGGGAGAGGGGGGGAGGGA 6132 UGGGAGAGGGGGGGAGGGAdTsdT antis
1965-1984 6133 CCCUCUCCCAGGUCCCUUG 6134 cccucucccAGGucccuuGdTsdT
sense 1965-1984 6135 CAAGGGACCUGGGAGAGGG 6136
cAAGGGACCUGGGAGAGGGdTsdT antis 1971-1990 6137 CCCAGGUCCCUUGUAAAUA
6138 cccAGGucccuuGuAAAuAdTsdT sense 1971-1990 6139
UAUUUACAAGGGACCUGGG 6140 uAUUuAcAAGGGACCUGGGdTsdT antis 1988-2007
6141 UAGAACCAGCCCAGCCCAU 6142 uAGAAccAGcccAGcccAudTsdT sense
1988-2007 6143 AUGGGCUGGGCUGGUUCUA 6144 AUGGGCUGGGCUGGUUCuAdTsdT
antis 2005-2024 6145 AUCUCUCGUCUUCCCUUCC 6146
AucucucGucuucccuuccdTsdT sense 2005-2024 6147 GGAAGGGAAGACGAGAGAU
6148 GGAAGGGAAGACGAGAGAUdTsdT antis 2006-2025 6149
UCUCUCGUCUUCCCUUCCC 6150 ucucucGucuucccuucccdTsdT sense 2006-2025
6151 GGGAAGGGAAGACGAGAGA 6152 GGGAAGGGAAGACGAGAGAdTsdT antis
2020-2039 6153 UUCCCUGGCCCCCUGGGUG 6154 uucccuGGcccccuGGGuGdTsdT
sense 2020-2039 6155 CACCCAGGGGGCCAGGGAA 6156
cACCcAGGGGGCcAGGGAAdTsdT antis 2039-2058 6157 UAAAUAGAUUGUUAUAAUU
6158 uAAAuAGAuuGuuAuAAuudTsdT sense 2039-2058 6159
AAUUAUAACAAUCUAUUUA 6160 AAUuAuAAcAAUCuAUUuAdTsdT antis 2050-2069
6161 UUAUAAUUUUUUCUUAAAG 6162 uuAuAAuuuuuucuuAAAGdTsdT sense
2050-2069 6163 CUUUAAGAAAAAAUUAUAA 6164 CUUuAAGAAAAAAUuAuAAdTsdT
antis 2052-2071 6165 AUAAUUUUUUCUUAAAGAA 6166
AuAAuuuuuucuuAAAGAAdTsdT sense 2052-2071 6167 UUCUUUAAGAAAAAAUUAU
6168 UUCUUuAAGAAAAAAUuAUdTsdT antis 2053-2072 6169
UAAUUUUUUCUUAAAGAAA 6170 uAAuuuuuucuuAAAGAAAdTsdT sense 2053-2072
6171 UUUCUUUAAGAAAAAAUUA 6172 UUUCUUuAAGAAAAAAUuAdTsdT antis
2054-2073 6173 AAUUUUUUCUUAAAGAAAA 6174 AAuuuuuucuuAAAGAAAAdTsdT
sense 2054-2073 6175 UUUUCUUUAAGAAAAAAUU 6176
UUUUCUUuAAGAAAAAAUUdTsdT antis 2110-2129 6177 UACCCCUUCUUGUCCUCUG
6178 uAccccuucuuGuccucuGdTsdT sense 2110-2129 6179
CAGAGGACAAGAAGGGGUA 6180 cAGAGGAcAAGAAGGGGuAdTsdT antis 2112-2131
6181 CCCCUUCUUGUCCUCUGCU 6182 ccccuucuuGuccucuGcudTsdT sense
2112-2131 6183 AGCAGAGGACAAGAAGGGG 6184 AGcAGAGGAcAAGAAGGGGdTsdT
antis 2113-2132 6185 CCCUUCUUGUCCUCUGCUC 6186
cccuucuuGuccucuGcucdTsdT sense 2113-2132 6187 GAGCAGAGGACAAGAAGGG
6188 GAGcAGAGGAcAAGAAGGGdTsdT antis 2114-2133 6189
CCUUCUUGUCCUCUGCUCC 6190 ccuucuuGuccucuGcuccdTsdT sense 2114-2133
6191 GGAGCAGAGGACAAGAAGG 6192 GGAGcAGAGGAcAAGAAGGdTsdT antis
2115-2134 6193 CUUCUUGUCCUCUGCUCCC 6194 cuucuuGuccucuGcucccdTsdT
sense 2115-2134 6195 GGGAGCAGAGGACAAGAAG 6196
GGGAGcAGAGGAcAAGAAGdTsdT antis 2126-2145 6197 CUGCUCCCAAGGCUUCCUC
6198 cuGcucccAAGGcuuccucdTsdT sense 2126-2145 6199
GAGGAAGCCUUGGGAGCAG 6200 GAGGAAGCCUUGGGAGcAGdTsdT antis 2131-2150
6201 CCCAAGGCUUCCUCCCUCU 6202 cccAAGGcuuccucccucudTsdT sense
2131-2150 6203 AGAGGGAGGAAGCCUUGGG 6204 AGAGGGAGGAAGCCUUGGGdTsdT
antis 2137-2156 6205 GCUUCCUCCCUCUCCCCAU 6206
GcuuccucccucuccccAudTsdT sense 2137-2156 6207 AUGGGGAGAGGGAGGAAGC
6208 AUGGGGAGAGGGAGGAAGCdTsdT antis 2138-2157 6209
CUUCCUCCCUCUCCCCAUC 6210 cuuccucccucuccccAucdTsdT sense 2138-2157
6211 GAUGGGGAGAGGGAGGAAG 6212 GAUGGGGAGAGGGAGGAAGdTsdT antis
2140-2159 6213 UCCUCCCUCUCCCCAUCCU 6214 uccucccucuccccAuccudTsdT
sense 2140-2159 6215 AGGAUGGGGAGAGGGAGGA 6216
AGGAUGGGGAGAGGGAGGAdTsdT antis 2141-2160 6217 CCUCCCUCUCCCCAUCCUG
6218 ccucccucuccccAuccuGdTsdT sense 2141-2160 6219
CAGGAUGGGGAGAGGGAGG 6220 cAGGAUGGGGAGAGGGAGGdTsdT antis 2145-2164
6221 CCUCUCCCCAUCCUGGAAG 6222 ccucuccccAuccuGGAAGdTsdT sense
2145-2164 6223 CUUCCAGGAUGGGGAGAGG 6224 CUUCcAGGAUGGGGAGAGGdTsdT
antis 2153-2172 6225 CAUCCUGGAAGGAGGGGAG 6226
cAuccuGGAAGGAGGGGAGdTsdT sense 2153-2172 6227 CUCCCCUCCUUCCAGGAUG
6228 CUCCCCUCCUUCcAGGAUGdTsdT antis 2172-2191 6229
UAGAGAGAGUCCCUGGUGU 6230 uAGAGAGAGucccuGGuGudTsdT sense 2172-2191
6231 ACACCAGGGACUCUCUCUA 6232 AcACcAGGGACUCUCUCuAdTsdT antis
2186-2205 6233 GGUGUCUUAGUUUCCACAG 6234 GGuGucuuAGuuuccAcAGdTsdT
sense 2186-2205 6235 CUGUGGAAACUAAGACACC 6236
CUGUGGAAACuAAGAcACCdTsdT antis 2193-2212 6237 UAGUUUCCACAGUAAGGUU
6238 uAGuuuccAcAGuAAGGuudTsdT sense 2193-2212 6239
AACCUUACUGUGGAAACUA 6240 AACCUuACUGUGGAAACuAdTsdT antis 2240-2259
6241 AUUAUUGGCAUGAAACCCU 6242 AuuAuuGGcAuGAAAcccudTsdT sense
2240-2259 6243 AGGGUUUCAUGCCAAUAAU 6244 AGGGUUUcAUGCcAAuAAUdTsdT
antis 62-81 6245 CUGGGCCGGAGCCGGAGCC 6246 cuGGGccGGAGccGGAGccdTsdT
sense 62-81 6247 GGCUCCGGCUCCGGCCCAG 6248 GGCUCCGGCUCCGGCCcAGdTsdT
antis 120-139 6249 GCGGCGGCAGAGGCAGCGG 6250
GcGGcGGcAGAGGcAGcGGdTsdT sense 120-139 6251 CCGCUGCCUCUGCCGCCGC
6252 CCGCUGCCUCUGCCGCCGCdTsdT antis 121-140 6253
CGGCGGCAGAGGCAGCGGC 6254 cGGcGGcAGAGGcAGcGGcdTsdT sense 121-140
6255 GCCGCUGCCUCUGCCGCCG 6256 GCCGCUGCCUCUGCCGCCGdTsdT antis
127-146 6257 CAGAGGCAGCGGCGGGGGC 6258 cAGAGGcAGcGGcGGGGGcdTsdT
sense 127-146 6259 GCCCCCGCCGCUGCCUCUG 6260
GCCCCCGCCGCUGCCUCUGdTsdT antis 142-161 6261 GGGCAGCCCAGGCAGCCCG
6262 GGGcAGcccAGGcAGcccGdTsdT sense
142-161 6263 CGGGCUGCCUGGGCUGCCC 6264 CGGGCUGCCUGGGCUGCCCdTsdT
antis 267-286 6265 GGAGGCGGAGGCGGAGGUG 6266
GGAGGcGGAGGcGGAGGuGdTsdT sense 267-286 6267 CACCUCCGCCUCCGCCUCC
6268 cACCUCCGCCUCCGCCUCCdTsdT antis 268-287 6269
GAGGCGGAGGCGGAGGUGG 6270 GAGGcGGAGGcGGAGGuGGdTsdT sense 268-287
6271 CCACCUCCGCCUCCGCCUC 6272 CcACCUCCGCCUCCGCCUCdTsdT antis
271-290 6273 GCGGAGGCGGAGGUGGUGG 6274 GcGGAGGcGGAGGuGGuGGdTsdT
sense 271-290 6275 CCACCACCUCCGCCUCCGC 6276
CcACcACCUCCGCCUCCGCdTsdT antis 284-303 6277 UGGUGGCGGCGGCCCCGGG
6278 uGGuGGcGGcGGccccGGGdTsdT sense 284-303 6279
CCCGGGGCCGCCGCCACCA 6280 CCCGGGGCCGCCGCcACcAdTsdT antis 591-610
6281 UACCAGGCACGGCUGGCAG 6282 uAccAGGcAcGGcuGGcAGdTsdT sense
591-610 6283 CUGCCAGCCGUGCCUGGUA 6284 CUGCcAGCCGUGCCUGGuAdTsdT
antis 1131-1150 6285 CUUCUCGGCCAGCCCAUCU 6286
cuucucGGccAGcccAucudTsdT sense 1131-1150 6287 AGAUGGGCUGGCCGAGAAG
6288 AGAUGGGCUGGCCGAGAAGdTsdT antis 1299-1318 6289
UCUUCAAAGACACCACCUG 6290 ucuucAAAGAcAccAccuGdTsdT sense 1299-1318
6291 CAGGUGGUGUCUUUGAAGA 6292 cAGGUGGUGUCUUUGAAGAdTsdT antis
1558-1577 6293 UCACCACUUCCUACAACCC 6294 ucAccAcuuccuAcAAcccdTsdT
sense 1558-1577 6295 GGGUUGUAGGAAGUGGUGA 6296
GGGUUGuAGGAAGUGGUGAdTsdT antis 1927-1946 6297 CCCCUCCCCUCCCCCAGGC
6298 ccccuccccucccccAGGcdTsdT sense 1927-1946 6299
GCCUGGGGGAGGGGAGGGG 6300 GCCUGGGGGAGGGGAGGGGdTsdT antis 1928-1947
6301 CCCUCCCCUCCCCCAGGCU 6302 cccuccccucccccAGGcudTsdT sense
1928-1947 6303 AGCCUGGGGGAGGGGAGGG 6304 AGCCUGGGGGAGGGGAGGGdTsdT
antis 2111-2130 6305 ACCCCUUCUUGUCCUCUGC 6306
AccccuucuuGuccucuGcdTsdT sense 2111-2130 6307 GCAGAGGACAAGAAGGGGU
6308 GcAGAGGAcAAGAAGGGGUdTsdT antis 2142-2161 6309
CUCCCUCUCCCCAUCCUGG 6310 cucccucuccccAuccuGGdTsdT sense 2142-2161
6311 CCAGGAUGGGGAGAGGGAG 6312 CcAGGAUGGGGAGAGGGAGdTsdT antis
2144-2163 6313 CCCUCUCCCCAUCCUGGAA 6314 cccucuccccAuccuGGAAdTsdT
sense 2144-2163 6315 UUCCAGGAUGGGGAGAGGG 6316
UUCcAGGAUGGGGAGAGGGdTsdT antis 1671-1690 6317 CACCGACUACCCCUCCACG
6318 cAccGAcuAccccuccAcGdTsdT sense 1671-1690 6319
CGUGGAGGGGUAGUCGGUG 6320 CGUGGAGGGGuAGUCGGUGdTsdT antis 1673-1692
6321 CCGACUACCCCUCCACGUC 6322 ccGAcuAccccuccAcGucdTsdT sense
1673-1692 6323 GACGUGGAGGGGUAGUCGG 6324 GACGUGGAGGGGuAGUCGGdTsdT
antis 1036-1055 6325 CUCGGUACUACCGUGCUCC 6326
cucGGuAcuAccGuGcuccdTsdT sense 1036-1055 6327 GGAGCACGGUAGUACCGAG
6328 GGAGcACGGuAGuACCGAGdTsdT antis 1035-1054 6329
UCUCGGUACUACCGUGCUC 6330 ucucGGuAcuAccGuGcucdTsdT sense 1035-1054
6331 GAGCACGGUAGUACCGAGA 6332 GAGcACGGuAGuACCGAGAdTsdT antis
1042-1061 6333 ACUACCGUGCUCCAGAACU 6334 AcuAccGuGcuccAGAAcudTsdT
sense 1042-1061 6335 AGUUCUGGAGCACGGUAGU 6336
AGUUCUGGAGcACGGuAGUdTsdT antis 1674-1693 6337 CGACUACCCCUCCACGUCC
6338 cGAcuAccccuccAcGuccdTsdT sense 1674-1693 6339
GGACGUGGAGGGGUAGUCG 6340 GGACGUGGAGGGGuAGUCGdTsdT antis 1787-1806
6341 AACUACCCCCAGCAUCUAG 6342 AAcuAcccccAGcAucuAGdTsdT sense
1787-1806 6343 CUAGAUGCUGGGGGUAGUU 6344 CuAGAUGCUGGGGGuAGUUdTsdT
antis 1034-1053 6345 CUCUCGGUACUACCGUGCU 6346
cucucGGuAcuAccGuGcudTsdT sense 1034-1053 6347 AGCACGGUAGUACCGAGAG
6348 AGcACGGuAGuACCGAGAGdTsdT antis 1202-1221 6349
AACGCCAACCAGGGAACAA 6350 AAcGccAAccAGGGAAcAAdTsdT sense 1202-1221
6351 UUGUUCCCUGGUUGGCGUU 6352 UUGUUCCCUGGUUGGCGUUdTsdT antis
776-795 6353 GGAGUAUGUGCCCGAGACG 6354 GGAGuAuGuGcccGAGAcGdTsdT
sense 776-795 6355 CGUCUCGGGCACAUACUCC 6356
CGUCUCGGGcAcAuACUCCdTsdT antis 779-798 6357 GUAUGUGCCCGAGACGGUG
6358 GuAuGuGcccGAGAcGGuGdTsdT sense 779-798 6359
CACCGUCUCGGGCACAUAC 6360 cACCGUCUCGGGcAcAuACdTsdT antis 780-799
6361 UAUGUGCCCGAGACGGUGU 6362 uAuGuGcccGAGAcGGuGudTsdT sense
780-799 6363 ACACCGUCUCGGGCACAUA 6364 AcACCGUCUCGGGcAcAuAdTsdT
antis 973-992 6365 UCUGCGAUUUUGGCAGUGC 6366
ucuGcGAuuuuGGcAGuGcdTsdT sense 973-992 6367 GCACUGCCAAAAUCGCAGA
6368 GcACUGCcAAAAUCGcAGAdTsdT antis 1038-1057 6369
CGGUACUACCGUGCUCCAG 6370 cGGuAcuAccGuGcuccAGdTsdT sense 1038-1057
6371 CUGGAGCACGGUAGUACCG 6372 CUGGAGcACGGuAGuACCGdTsdT antis
1041-1060 6373 UACUACCGUGCUCCAGAAC 6374 uAcuAccGuGcuccAGAAcdTsdT
sense 1041-1060 6375 GUUCUGGAGCACGGUAGUA 6376
GUUCUGGAGcACGGuAGuAdTsdT antis 1043-1062 6377 CUACCGUGCUCCAGAACUC
6378 cuAccGuGcuccAGAAcucdTsdT sense 1043-1062 6379
GAGUUCUGGAGCACGGUAG 6380 GAGUUCUGGAGcACGGuAGdTsdT antis 1189-1208
6381 UCAAGGUACUAGGAACGCC 6382 ucAAGGuAcuAGGAAcGccdTsdT sense
1189-1208 6383 GGCGUUCCUAGUACCUUGA 6384 GGCGUUCCuAGuACCUUGAdTsdT
antis 1190-1209 6385 CAAGGUACUAGGAACGCCA 6386
cAAGGuAcuAGGAAcGccAdTsdT sense 1190-1209 6387 UGGCGUUCCUAGUACCUUG
6388 UGGCGUUCCuAGuACCUUGdTsdT antis 1191-1210 6389
AAGGUACUAGGAACGCCAA 6390 AAGGuAcuAGGAAcGccAAdTsdT sense 1191-1210
6391 UUGGCGUUCCUAGUACCUU 6392 UUGGCGUUCCuAGuACCUUdTsdT antis
1192-1211 6393 AGGUACUAGGAACGCCAAC 6394 AGGuAcuAGGAAcGccAAcdTsdT
sense 1192-1211 6395 GUUGGCGUUCCUAGUACCU 6396
GUUGGCGUUCCuAGuACCUdTsdT antis 1197-1216 6397 CUAGGAACGCCAACCAGGG
6398 cuAGGAAcGccAAccAGGGdTsdT sense 1197-1216 6399
CCCUGGUUGGCGUUCCUAG 6400 CCCUGGUUGGCGUUCCuAGdTsdT antis 1203-1222
6401 ACGCCAACCAGGGAACAAA 6402 AcGccAAccAGGGAAcAAAdTsdT sense
1203-1222 6403 UUUGUUCCCUGGUUGGCGU 6404 UUUGUUCCCUGGUUGGCGUdTsdT
antis 1670-1689 6405 CCACCGACUACCCCUCCAC 6406
ccAccGAcuAccccuccAcdTsdT sense 1670-1689 6407 GUGGAGGGGUAGUCGGUGG
6408 GUGGAGGGGuAGUCGGUGGdTsdT antis 1672-1691 6409
ACCGACUACCCCUCCACGU 6410 AccGAcuAccccuccAcGudTsdT sense 1672-1691
6411 ACGUGGAGGGGUAGUCGGU 6412 ACGUGGAGGGGuAGUCGGUdTsdT antis
1780-1799 6413 GUAAAUGAACUACCCCCAG 6414 GuAAAuGAAcuAcccccAGdTsdT
sense 1780-1799 6415 CUGGGGGUAGUUCAUUUAC 6416
CUGGGGGuAGUUcAUUuACdTsdT antis 1786-1805 6417 GAACUACCCCCAGCAUCUA
6418 GAAcuAcccccAGcAucuAdTsdT sense 1786-1805 6419
UAGAUGCUGGGGGUAGUUC 6420 uAGAUGCUGGGGGuAGUUCdTsdT antis 352-371
6421 GGGCUAUGGGUGGGGGCGU 6422 GGGcuAuGGGuGGGGGcGudTsdT sense
352-371 6423 ACGCCCCCACCCAUAGCCC 6424 ACGCCCCcACCcAuAGCCCdTsdT
antis 354-373 6425 GCUAUGGGUGGGGGCGUGG 6426
GcuAuGGGuGGGGGcGuGGdTsdT sense 354-373 6427 CCACGCCCCCACCCAUAGC
6428 CcACGCCCCcACCcAuAGCdTsdT antis 521-540 6429
CCCAGAGCGUUCCCAAGAA 6430 cccAGAGcGuucccAAGAAdTsdT sense 521-540
6431 UUCUUGGGAACGCUCUGGG 6432 UUCUUGGGAACGCUCUGGGdTsdT antis
523-542 6433 CAGAGCGUUCCCAAGAAGU 6434 cAGAGcGuucccAAGAAGudTsdT
sense 523-542 6435 ACUUCUUGGGAACGCUCUG 6436
ACUUCUUGGGAACGCUCUGdTsdT antis 524-543 6437 AGAGCGUUCCCAAGAAGUG
6438 AGAGcGuucccAAGAAGuGdTsdT sense 524-543 6439
CACUUCUUGGGAACGCUCU 6440 cACUUCUUGGGAACGCUCUdTsdT antis 527-546
6441 GCGUUCCCAAGAAGUGGCU 6442 GcGuucccAAGAAGuGGcudTsdT sense
527-546 6443 AGCCACUUCUUGGGAACGC 6444 AGCcACUUCUUGGGAACGCdTsdT
antis 550-569 6445 CUGACAUCAAAGUGAUUGG 6446
cuGAcAucAAAGuGAuuGGdTsdT sense 550-569 6447 CCAAUCACUUUGAUGUCAG
6448 CcAAUcACUUUGAUGUcAGdTsdT antis 568-587 6449
GUAAUGGCUCAUUCGGAGU 6450 GuAAuGGcucAuucGGAGudTsdT sense 568-587
6451 ACUCCGAAUGAGCCAUUAC 6452 ACUCCGAAUGAGCcAUuACdTsdT antis
569-588 6453 UAAUGGCUCAUUCGGAGUA 6454 uAAuGGcucAuucGGAGuAdTsdT
sense 569-588 6455 UACUCCGAAUGAGCCAUUA 6456
uACUCCGAAUGAGCcAUuAdTsdT antis 570-589 6457 AAUGGCUCAUUCGGAGUAG
6458 AAuGGcucAuucGGAGuAGdTsdT sense 570-589 6459
CUACUCCGAAUGAGCCAUU 6460 CuACUCCGAAUGAGCcAUUdTsdT antis 572-591
6461 UGGCUCAUUCGGAGUAGUA 6462 uGGcucAuucGGAGuAGuAdTsdT sense
572-591 6463 UACUACUCCGAAUGAGCCA 6464 uACuACUCCGAAUGAGCcAdTsdT
antis 626-645 6465 GGCCAUCAAGAAGGUUCUU 6466
GGccAucAAGAAGGuucuudTsdT sense 626-645 6467 AAGAACCUUCUUGAUGGCC
6468 AAGAACCUUCUUGAUGGCCdTsdT antis 688-707 6469
AGCUGGACCACUGCAAUAU 6470 AGcuGGAccAcuGcAAuAudTsdT sense 688-707
6471 AUAUUGCAGUGGUCCAGCU 6472 AuAUUGcAGUGGUCcAGCUdTsdT antis
693-712 6473 GACCACUGCAAUAUUGUGA 6474 GAccAcuGcAAuAuuGuGAdTsdT
sense 693-712 6475 UCACAAUAUUGCAGUGGUC 6476
UcAcAAuAUUGcAGUGGUCdTsdT antis 697-716 6477 ACUGCAAUAUUGUGAGGCU
6478 AcuGcAAuAuuGuGAGGcudTsdT sense 697-716 6479
AGCCUCACAAUAUUGCAGU 6480 AGCCUcAcAAuAUUGcAGUdTsdT antis 724-743
6481 UUUUCUACUCCAGUGGGGA 6482 uuuucuAcuccAGuGGGGAdTsdT sense
724-743 6483 UCCCCACUGGAGUAGAAAA 6484 UCCCcACUGGAGuAGAAAAdTsdT
antis 725-744 6485 UUUCUACUCCAGUGGGGAG 6486
uuucuAcuccAGuGGGGAGdTsdT sense 725-744 6487 CUCCCCACUGGAGUAGAAA
6488 CUCCCcACUGGAGuAGAAAdTsdT antis 726-745 6489
UUCUACUCCAGUGGGGAGA 6490 uucuAcuccAGuGGGGAGAdTsdT sense 726-745
6491 UCUCCCCACUGGAGUAGAA 6492 UCUCCCcACUGGAGuAGAAdTsdT antis
727-746 6493 UCUACUCCAGUGGGGAGAA 6494 ucuAcuccAGuGGGGAGAAdTsdT
sense 727-746 6495 UUCUCCCCACUGGAGUAGA 6496
UUCUCCCcACUGGAGuAGAdTsdT antis 757-776 6497 UGUAUUUGAAUCUGGUGCU
6498 uGuAuuuGAAucuGGuGcudTsdT sense 757-776 6499
AGCACCAGAUUCAAAUACA 6500 AGcACcAGAUUcAAAuAcAdTsdT antis 759-778
6501 UAUUUGAAUCUGGUGCUGG 6502 uAuuuGAAucuGGuGcuGGdTsdT sense
759-778 6503 CCAGCACCAGAUUCAAAUA 6504 CcAGcACcAGAUUcAAAuAdTsdT
antis 760-779 6505 AUUUGAAUCUGGUGCUGGA 6506
AuuuGAAucuGGuGcuGGAdTsdT sense 760-779 6507 UCCAGCACCAGAUUCAAAU
6508 UCcAGcACcAGAUUcAAAUdTsdT antis 762-781 6509
UUGAAUCUGGUGCUGGAGU 6510 uuGAAucuGGuGcuGGAGudTsdT sense 762-781
6511 ACUCCAGCACCAGAUUCAA 6512 ACUCcAGcACcAGAUUcAAdTsdT antis
763-782 6513 UGAAUCUGGUGCUGGAGUA 6514 uGAAucuGGuGcuGGAGuAdTsdT
sense
763-782 6515 UACUCCAGCACCAGAUUCA 6516 uACUCcAGcACcAGAUUcAdTsdT
antis 775-794 6517 UGGAGUAUGUGCCCGAGAC 6518
uGGAGuAuGuGcccGAGAcdTsdT sense 775-794 6519 GUCUCGGGCACAUACUCCA
6520 GUCUCGGGcAcAuACUCcAdTsdT antis 778-797 6521
AGUAUGUGCCCGAGACGGU 6522 AGuAuGuGcccGAGAcGGudTsdT sense 778-797
6523 ACCGUCUCGGGCACAUACU 6524 ACCGUCUCGGGcAcAuACUdTsdT antis
854-873 6525 CAAGGUGUACAUGUACCAG 6526 cAAGGuGuAcAuGuAccAGdTsdT
sense 854-873 6527 CUGGUACAUGUACACCUUG 6528
CUGGuAcAUGuAcACCUUGdTsdT antis 855-874 6529 AAGGUGUACAUGUACCAGC
6530 AAGGuGuAcAuGuAccAGcdTsdT sense 855-874 6531
GCUGGUACAUGUACACCUU 6532 GCUGGuAcAUGuAcACCUUdTsdT antis 856-875
6533 AGGUGUACAUGUACCAGCU 6534 AGGuGuAcAuGuAccAGcudTsdT sense
856-875 6535 AGCUGGUACAUGUACACCU 6536 AGCUGGuAcAUGuAcACCUdTsdT
antis 857-876 6537 GGUGUACAUGUACCAGCUC 6538
GGuGuAcAuGuAccAGcucdTsdT sense 857-876 6539 GAGCUGGUACAUGUACACC
6540 GAGCUGGuAcAUGuAcACCdTsdT antis 915-934 6541
CACCGUGACAUCAAGCCCC 6542 cAccGuGAcAucAAGccccdTsdT sense 915-934
6543 GGGGCUUGAUGUCACGGUG 6544 GGGGCUUGAUGUcACGGUGdTsdT antis
938-957 6545 UUUGCUUGUGGACCCUGAC 6546 uuuGcuuGuGGAcccuGAcdTsdT
sense 938-957 6547 GUCAGGGUCCACAAGCAAA 6548
GUcAGGGUCcAcAAGcAAAdTsdT antis 945-964 6549 GUGGACCCUGACACUGCUG
6550 GuGGAcccuGAcAcuGcuGdTsdT sense 945-964 6551
CAGCAGUGUCAGGGUCCAC 6552 cAGcAGUGUcAGGGUCcACdTsdT antis 971-990
6553 GCUCUGCGAUUUUGGCAGU 6554 GcucuGcGAuuuuGGcAGudTsdT sense
971-990 6555 ACUGCCAAAAUCGCAGAGC 6556 ACUGCcAAAAUCGcAGAGCdTsdT
antis 972-991 6557 CUCUGCGAUUUUGGCAGUG 6558
cucuGcGAuuuuGGcAGuGdTsdT sense 972-991 6559 CACUGCCAAAAUCGCAGAG
6560 cACUGCcAAAAUCGcAGAGdTsdT antis 975-994 6561
UGCGAUUUUGGCAGUGCAA 6562 uGcGAuuuuGGcAGuGcAAdTsdT sense 975-994
6563 UUGCACUGCCAAAAUCGCA 6564 UUGcACUGCcAAAAUCGcAdTsdT antis
979-998 6565 AUUUUGGCAGUGCAAAGCA 6566 AuuuuGGcAGuGcAAAGcAdTsdT
sense 979-998 6567 UGCUUUGCACUGCCAAAAU 6568
UGCUUUGcACUGCcAAAAUdTsdT antis 1037-1056 6569 UCGGUACUACCGUGCUCCA
6570 ucGGuAcuAccGuGcuccAdTsdT sense 1037-1056 6571
UGGAGCACGGUAGUACCGA 6572 UGGAGcACGGuAGuACCGAdTsdT antis 1040-1059
6573 GUACUACCGUGCUCCAGAA 6574 GuAcuAccGuGcuccAGAAdTsdT sense
1040-1059 6575 UUCUGGAGCACGGUAGUAC 6576 UUCUGGAGcACGGuAGuACdTsdT
antis 1169-1188 6577 GGACCAGCUUGUGGAGAUC 6578
GGAccAGcuuGuGGAGAucdTsdT sense 1169-1188 6579 GAUCUCCACAAGCUGGUCC
6580 GAUCUCcAcAAGCUGGUCCdTsdT antis 1174-1193 6581
AGCUUGUGGAGAUCAUCAA 6582 AGcuuGuGGAGAucAucAAdTsdT sense 1174-1193
6583 UUGAUGAUCUCCACAAGCU 6584 UUGAUGAUCUCcAcAAGCUdTsdT antis
1178-1197 6585 UGUGGAGAUCAUCAAGGUA 6586 uGuGGAGAucAucAAGGuAdTsdT
sense 1178-1197 6587 UACCUUGAUGAUCUCCACA 6588
uACCUUGAUGAUCUCcAcAdTsdT antis 1183-1202 6589 AGAUCAUCAAGGUACUAGG
6590 AGAucAucAAGGuAcuAGGdTsdT sense 1183-1202 6591
CCUAGUACCUUGAUGAUCU 6592 CCuAGuACCUUGAUGAUCUdTsdT antis 1193-1212
6593 GGUACUAGGAACGCCAACC 6594 GGuAcuAGGAAcGccAAccdTsdT sense
1193-1212 6595 GGUUGGCGUUCCUAGUACC 6596 GGUUGGCGUUCCuAGuACCdTsdT
antis 1194-1213 6597 GUACUAGGAACGCCAACCA 6598
GuAcuAGGAAcGccAAccAdTsdT sense 1194-1213 6599 UGGUUGGCGUUCCUAGUAC
6600 UGGUUGGCGUUCCuAGuACdTsdT antis 1195-1214 6601
UACUAGGAACGCCAACCAG 6602 uAcuAGGAAcGccAAccAGdTsdT sense 1195-1214
6603 CUGGUUGGCGUUCCUAGUA 6604 CUGGUUGGCGUUCCuAGuAdTsdT antis
1198-1217 6605 UAGGAACGCCAACCAGGGA 6606 uAGGAAcGccAAccAGGGAdTsdT
sense 1198-1217 6607 UCCCUGGUUGGCGUUCCUA 6608
UCCCUGGUUGGCGUUCCuAdTsdT antis 1199-1218 6609 AGGAACGCCAACCAGGGAA
6610 AGGAAcGccAAccAGGGAAdTsdT sense 1199-1218 6611
UUCCCUGGUUGGCGUUCCU 6612 UUCCCUGGUUGGCGUUCCUdTsdT antis 1200-1219
6613 GGAACGCCAACCAGGGAAC 6614 GGAAcGccAAccAGGGAAcdTsdT sense
1200-1219 6615 GUUCCCUGGUUGGCGUUCC 6616 GUUCCCUGGUUGGCGUUCCdTsdT
antis 1201-1220 6617 GAACGCCAACCAGGGAACA 6618
GAAcGccAAccAGGGAAcAdTsdT sense 1201-1220 6619 UGUUCCCUGGUUGGCGUUC
6620 UGUUCCCUGGUUGGCGUUCdTsdT antis 1206-1225 6621
CCAACCAGGGAACAAAUCC 6622 ccAAccAGGGAAcAAAuccdTsdT sense 1206-1225
6623 GGAUUUGUUCCCUGGUUGG 6624 GGAUUUGUUCCCUGGUUGGdTsdT antis
1208-1227 6625 AACCAGGGAACAAAUCCGA 6626 AAccAGGGAAcAAAuccGAdTsdT
sense 1208-1227 6627 UCGGAUUUGUUCCCUGGUU 6628
UCGGAUUUGUUCCCUGGUUdTsdT antis 1218-1237 6629 CAAAUCCGAGAGAUGAACC
6630 cAAAuccGAGAGAuGAAccdTsdT sense 1218-1237 6631
GGUUCAUCUCUCGGAUUUG 6632 GGUUcAUCUCUCGGAUUUGdTsdT antis 1220-1239
6633 AAUCCGAGAGAUGAACCCU 6634 AAuccGAGAGAuGAAcccudTsdT sense
1220-1239 6635 AGGGUUCAUCUCUCGGAUU 6636 AGGGUUcAUCUCUCGGAUUdTsdT
antis 1221-1240 6637 AUCCGAGAGAUGAACCCUA 6638
AuccGAGAGAuGAAcccuAdTsdT sense 1221-1240 6639 UAGGGUUCAUCUCUCGGAU
6640 uAGGGUUcAUCUCUCGGAUdTsdT antis 1453-1472 6641
CCCCCCUGUUCAACUUCAG 6642 ccccccuGuucAAcuucAGdTsdT sense 1453-1472
6643 CUGAAGUUGAACAGGGGGG 6644 CUGAAGUUGAAcAGGGGGGdTsdT antis
1675-1694 6645 GACUACCCCUCCACGUCCA 6646 GAcuAccccuccAcGuccAdTsdT
sense 1675-1694 6647 UGGACGUGGAGGGGUAGUC 6648
UGGACGUGGAGGGGuAGUCdTsdT antis 1676-1695 6649 ACUACCCCUCCACGUCCAU
6650 AcuAccccuccAcGuccAudTsdT sense 1676-1695 6651
AUGGACGUGGAGGGGUAGU 6652 AUGGACGUGGAGGGGuAGUdTsdT antis 1677-1696
6653 CUACCCCUCCACGUCCAUC 6654 cuAccccuccAcGuccAucdTsdT sense
1677-1696 6655 GAUGGACGUGGAGGGGUAG 6656 GAUGGACGUGGAGGGGuAGdTsdT
antis 1703-1722 6657 GCCCAAGUGGCGCUGGGAA 6658
GcccAAGuGGcGcuGGGAAdTsdT sense 1703-1722 6659 UUCCCAGCGCCACUUGGGC
6660 UUCCcAGCGCcACUUGGGCdTsdT antis 1706-1725 6661
CAAGUGGCGCUGGGAAGGG 6662 cAAGuGGcGcuGGGAAGGGdTsdT sense 1706-1725
6663 CCCUUCCCAGCGCCACUUG 6664 CCCUUCCcAGCGCcACUUGdTsdT antis
1752-1771 6665 GGCUGGGCCCCUAGACUAG 6666 GGcuGGGccccuAGAcuAGdTsdT
sense 1752-1771 6667 CUAGUCUAGGGGCCCAGCC 6668
CuAGUCuAGGGGCCcAGCCdTsdT antis 1755-1774 6669 UGGGCCCCUAGACUAGAGG
6670 uGGGccccuAGAcuAGAGGdTsdT sense 1755-1774 6671
CCUCUAGUCUAGGGGCCCA 6672 CCUCuAGUCuAGGGGCCcAdTsdT antis 1758-1777
6673 GCCCCUAGACUAGAGGGCA 6674 GccccuAGAcuAGAGGGcAdTsdT sense
1758-1777 6675 UGCCCUCUAGUCUAGGGGC 6676 UGCCCUCuAGUCuAGGGGCdTsdT
antis 1761-1780 6677 CCUAGACUAGAGGGCAGAG 6678
ccuAGAcuAGAGGGcAGAGdTsdT sense 1761-1780 6679 CUCUGCCCUCUAGUCUAGG
6680 CUCUGCCCUCuAGUCuAGGdTsdT antis 1765-1784 6681
GACUAGAGGGCAGAGGUAA 6682 GAcuAGAGGGcAGAGGuAAdTsdT sense 1765-1784
6683 UUACCUCUGCCCUCUAGUC 6684 UuACCUCUGCCCUCuAGUCdTsdT antis
1777-1796 6685 GAGGUAAAUGAACUACCCC 6686 GAGGuAAAuGAAcuAccccdTsdT
sense 1777-1796 6687 GGGGUAGUUCAUUUACCUC 6688
GGGGuAGUUcAUUuACCUCdTsdT antis 1778-1797 6689 AGGUAAAUGAACUACCCCC
6690 AGGuAAAuGAAcuAcccccdTsdT sense 1778-1797 6691
GGGGGUAGUUCAUUUACCU 6692 GGGGGuAGUUcAUUuACCUdTsdT antis 1779-1798
6693 GGUAAAUGAACUACCCCCA 6694 GGuAAAuGAAcuAcccccAdTsdT sense
1779-1798 6695 UGGGGGUAGUUCAUUUACC 6696 UGGGGGuAGUUcAUUuACCdTsdT
antis 1781-1800 6697 UAAAUGAACUACCCCCAGC 6698
uAAAuGAAcuAcccccAGcdTsdT sense 1781-1800 6699 GCUGGGGGUAGUUCAUUUA
6700 GCUGGGGGuAGUUcAUUuAdTsdT antis 1792-1811 6701
CCCCCAGCAUCUAGGCCUC 6702 cccccAGcAucuAGGccucdTsdT sense 1792-1811
6703 GAGGCCUAGAUGCUGGGGG 6704 GAGGCCuAGAUGCUGGGGGdTsdT antis
1796-1815 6705 CAGCAUCUAGGCCUCCCUC 6706 cAGcAucuAGGccucccucdTsdT
sense 1796-1815 6707 GAGGGAGGCCUAGAUGCUG 6708
GAGGGAGGCCuAGAUGCUGdTsdT antis 1885-1904 6709 AGGACGGGGUUUGGGGGUG
6710 AGGAcGGGGuuuGGGGGuGdTsdT sense 1885-1904 6711
CACCCCCAAACCCCGUCCU 6712 cACCCCcAAACCCCGUCCUdTsdT antis 522-541
6713 CCAGAGCGUUCCCAAGAAG 6714 ccAGAGcGuucccAAGAAGdTsdT sense
522-541 6715 CUUCUUGGGAACGCUCUGG 6716 CUUCUUGGGAACGCUCUGGdTsdT
antis 526-545 6717 AGCGUUCCCAAGAAGUGGC 6718
AGcGuucccAAGAAGuGGcdTsdT sense 526-545 6719 GCCACUUCUUGGGAACGCU
6720 GCcACUUCUUGGGAACGCUdTsdT antis 700-719 6721
GCAAUAUUGUGAGGCUGCG 6722 GcAAuAuuGuGAGGcuGcGdTsdT sense 700-719
6723 CGCAGCCUCACAAUAUUGC 6724 CGcAGCCUcAcAAuAUUGCdTsdT antis
873-892 6725 CUCUUCCGGAGCUUGGCCU 6726 cucuuccGGAGcuuGGccudTsdT
sense 873-892 6727 AGGCCAAGCUCCGGAAGAG 6728
AGGCcAAGCUCCGGAAGAGdTsdT antis 1256-1275 6729 GUUCCCCCAGAUCAAAGCU
6730 GuucccccAGAucAAAGcudTsdT sense 1256-1275 6731
AGCUUUGAUCUGGGGGAAC 6732 AGCUUUGAUCUGGGGGAACdTsdT antis 1317-1336
6733 GAGGCCAUUGCACUCUGCU 6734 GAGGccAuuGcAcucuGcudTsdT sense
1317-1336 6735 AGCAGAGUGCAAUGGCCUC 6736 AGcAGAGUGcAAUGGCCUCdTsdT
antis 1512-1531 6737 CUCAUCCCUCCUCACUUGA 6738
cucAucccuccucAcuuGAdTsdT sense 1512-1531 6739 UCAAGUGAGGAGGGAUGAG
6740 UcAAGUGAGGAGGGAUGAGdTsdT antis 1764-1783 6741
AGACUAGAGGGCAGAGGUA 6742 AGAcuAGAGGGcAGAGGuAdTsdT sense 1764-1783
6743 UACCUCUGCCCUCUAGUCU 6744 uACCUCUGCCCUCuAGUCUdTsdT antis
236-255 6745 CCGGGCGCGGACCAGCUCG 6746 ccGGGcGcGGAccAGcucGdTsdT
sense 236-255 6747 CGAGCUGGUCCGCGCCCGG 6748
CGAGCUGGUCCGCGCCCGGdTsdT antis 914-933 6749 UCACCGUGACAUCAAGCCC
6750 ucAccGuGAcAucAAGcccdTsdT sense 914-933 6751
GGGCUUGAUGUCACGGUGA 6752 GGGCUUGAUGUcACGGUGAdTsdT antis 234-253
6753 GGCCGGGCGCGGACCAGCU 6754 GGccGGGcGcGGAccAGcudTsdT sense
234-253 6755 AGCUGGUCCGCGCCCGGCC 6756 AGCUGGUCCGCGCCCGGCCdTsdT
antis 520-539 6757 GCCCAGAGCGUUCCCAAGA 6758
GcccAGAGcGuucccAAGAdTsdT sense 520-539 6759 UCUUGGGAACGCUCUGGGC
6760 UCUUGGGAACGCUCUGGGCdTsdT antis 525-544 6761
GAGCGUUCCCAAGAAGUGG 6762 GAGcGuucccAAGAAGuGGdTsdT sense 525-544
6763 CCACUUCUUGGGAACGCUC 6764 CcACUUCUUGGGAACGCUCdTsdT antis
549-568 6765 ACUGACAUCAAAGUGAUUG 6766 AcuGAcAucAAAGuGAuuGdTsdT
sense 549-568 6767 CAAUCACUUUGAUGUCAGU 6768
cAAUcACUUUGAUGUcAGUdTsdT antis 555-574 6769 AUCAAAGUGAUUGGUAAUG
6770 AucAAAGuGAuuGGuAAuGdTsdT sense 555-574 6771
CAUUACCAAUCACUUUGAU 6772 cAUuACcAAUcACUUUGAUdTsdT antis 558-577
6773 AAAGUGAUUGGUAAUGGCU 6774 AAAGuGAuuGGuAAuGGcudTsdT sense
558-577 6775 AGCCAUUACCAAUCACUUU 6776 AGCcAUuACcAAUcACUUUdTsdT
antis 567-586 6777 GGUAAUGGCUCAUUCGGAG 6778
GGuAAuGGcucAuucGGAGdTsdT sense 567-586 6779 CUCCGAAUGAGCCAUUACC
6780 CUCCGAAUGAGCcAUuACCdTsdT antis 571-590 6781
AUGGCUCAUUCGGAGUAGU 6782 AuGGcucAuucGGAGuAGudTsdT sense 571-590
6783 ACUACUCCGAAUGAGCCAU 6784 ACuACUCCGAAUGAGCcAUdTsdT antis
685-704 6785 GUAAGCUGGACCACUGCAA 6786 GuAAGcuGGAccAcuGcAAdTsdT
sense 685-704 6787 UUGCAGUGGUCCAGCUUAC 6788
UUGcAGUGGUCcAGCUuACdTsdT antis 764-783 6789 GAAUCUGGUGCUGGAGUAU
6790 GAAucuGGuGcuGGAGuAudTsdT sense 764-783 6791
AUACUCCAGCACCAGAUUC 6792 AuACUCcAGcACcAGAUUCdTsdT antis 777-796
6793 GAGUAUGUGCCCGAGACGG 6794 GAGuAuGuGcccGAGAcGGdTsdT sense
777-796 6795 CCGUCUCGGGCACAUACUC 6796 CCGUCUCGGGcAcAuACUCdTsdT
antis 783-802 6797 GUGCCCGAGACGGUGUACC 6798
GuGcccGAGAcGGuGuAccdTsdT sense 783-802 6799 GGUACACCGUCUCGGGCAC
6800 GGuAcACCGUCUCGGGcACdTsdT antis 802-821 6801
GAGUGGCCCGCCACUUCAC 6802 GAGuGGcccGccAcuucAcdTsdT sense 802-821
6803 GUGAAGUGGCGGGCCACUC 6804 GUGAAGUGGCGGGCcACUCdTsdT antis
818-837 6805 CACCAAGGCCAAGCUGAUC 6806 cAccAAGGccAAGcuGAucdTsdT
sense 818-837 6807 GAUCAGCUUGGCCUUGGUG 6808
GAUcAGCUUGGCCUUGGUGdTsdT antis 852-871 6809 AUCAAGGUGUACAUGUACC
6810 AucAAGGuGuAcAuGuAccdTsdT sense 852-871 6811
GGUACAUGUACACCUUGAU 6812 GGuAcAUGuAcACCUUGAUdTsdT antis 853-872
6813 UCAAGGUGUACAUGUACCA 6814 ucAAGGuGuAcAuGuAccAdTsdT sense
853-872 6815 UGGUACAUGUACACCUUGA 6816 UGGuAcAUGuAcACCUUGAdTsdT
antis 937-956 6817 AUUUGCUUGUGGACCCUGA 6818
AuuuGcuuGuGGAcccuGAdTsdT sense 937-956 6819 UCAGGGUCCACAAGCAAAU
6820 UcAGGGUCcAcAAGcAAAUdTsdT antis 942-961 6821
CUUGUGGACCCUGACACUG 6822 cuuGuGGAcccuGAcAcuGdTsdT sense 942-961
6823 CAGUGUCAGGGUCCACAAG 6824 cAGUGUcAGGGUCcAcAAGdTsdT antis
967-986 6825 UCAAGCUCUGCGAUUUUGG 6826 ucAAGcucuGcGAuuuuGGdTsdT
sense 967-986 6827 CCAAAAUCGCAGAGCUUGA 6828
CcAAAAUCGcAGAGCUUGAdTsdT antis 968-987 6829 CAAGCUCUGCGAUUUUGGC
6830 cAAGcucuGcGAuuuuGGcdTsdT sense 968-987 6831
GCCAAAAUCGCAGAGCUUG 6832 GCcAAAAUCGcAGAGCUUGdTsdT antis 976-995
6833 GCGAUUUUGGCAGUGCAAA 6834 GcGAuuuuGGcAGuGcAAAdTsdT sense
976-995 6835 UUUGCACUGCCAAAAUCGC 6836 UUUGcACUGCcAAAAUCGCdTsdT
antis 984-1003 6837 GGCAGUGCAAAGCAGCUGG 6838
GGcAGuGcAAAGcAGcuGGdTsdT sense 984-1003 6839 CCAGCUGCUUUGCACUGCC
6840 CcAGCUGCUUUGcACUGCCdTsdT antis 1039-1058 6841
GGUACUACCGUGCUCCAGA 6842 GGuAcuAccGuGcuccAGAdTsdT sense 1039-1058
6843 UCUGGAGCACGGUAGUACC 6844 UCUGGAGcACGGuAGuACCdTsdT antis
1044-1063 6845 UACCGUGCUCCAGAACUCA 6846 uAccGuGcuccAGAAcucAdTsdT
sense 1044-1063 6847 UGAGUUCUGGAGCACGGUA 6848
UGAGUUCUGGAGcACGGuAdTsdT antis 1185-1204 6849 AUCAUCAAGGUACUAGGAA
6850 AucAucAAGGuAcuAGGAAdTsdT sense 1185-1204 6851
UUCCUAGUACCUUGAUGAU 6852 UUCCuAGuACCUUGAUGAUdTsdT antis 1188-1207
6853 AUCAAGGUACUAGGAACGC 6854 AucAAGGuAcuAGGAAcGcdTsdT sense
1188-1207 6855 GCGUUCCUAGUACCUUGAU 6856 GCGUUCCuAGuACCUUGAUdTsdT
antis 1196-1215 6857 ACUAGGAACGCCAACCAGG 6858
AcuAGGAAcGccAAccAGGdTsdT sense 1196-1215 6859 CCUGGUUGGCGUUCCUAGU
6860 CCUGGUUGGCGUUCCuAGUdTsdT antis 1204-1223 6861
CGCCAACCAGGGAACAAAU 6862 cGccAAccAGGGAAcAAAudTsdT sense 1204-1223
6863 AUUUGUUCCCUGGUUGGCG 6864 AUUUGUUCCCUGGUUGGCGdTsdT antis
1213-1232 6865 GGGAACAAAUCCGAGAGAU 6866 GGGAAcAAAuccGAGAGAudTsdT
sense 1213-1232 6867 AUCUCUCGGAUUUGUUCCC 6868
AUCUCUCGGAUUUGUUCCCdTsdT antis 1215-1234 6869 GAACAAAUCCGAGAGAUGA
6870 GAAcAAAuccGAGAGAuGAdTsdT sense 1215-1234 6871
UCAUCUCUCGGAUUUGUUC 6872 UcAUCUCUCGGAUUUGUUCdTsdT antis 1216-1235
6873 AACAAAUCCGAGAGAUGAA 6874 AAcAAAuccGAGAGAuGAAdTsdT sense
1216-1235 6875 UUCAUCUCUCGGAUUUGUU 6876 UUcAUCUCUCGGAUUUGUUdTsdT
antis 1217-1236 6877 ACAAAUCCGAGAGAUGAAC 6878
AcAAAuccGAGAGAuGAAcdTsdT sense 1217-1236 6879 GUUCAUCUCUCGGAUUUGU
6880 GUUcAUCUCUCGGAUUUGUdTsdT antis 1429-1448 6881
AGCUCCCCAACGACCGCCC 6882 AGcuccccAAcGAccGcccdTsdT sense 1429-1448
6883 GGGCGGUCGUUGGGGAGCU 6884 GGGCGGUCGUUGGGGAGCUdTsdT antis
1430-1449 6885 GCUCCCCAACGACCGCCCG 6886 GcuccccAAcGAccGcccGdTsdT
sense 1430-1449 6887 CGGGCGGUCGUUGGGGAGC 6888
CGGGCGGUCGUUGGGGAGCdTsdT antis 1580-1599 6889 CUCACAAGCUUUAACUGAA
6890 cucAcAAGcuuuAAcuGAAdTsdT sense 1580-1599 6891
UUCAGUUAAAGCUUGUGAG 6892 UUcAGUuAAAGCUUGUGAGdTsdT antis 1667-1686
6893 GCCCCACCGACUACCCCUC 6894 GccccAccGAcuAccccucdTsdT sense
1667-1686 6895 GAGGGGUAGUCGGUGGGGC 6896 GAGGGGuAGUCGGUGGGGCdTsdT
antis 1669-1688 6897 CCCACCGACUACCCCUCCA 6898
cccAccGAcuAccccuccAdTsdT sense 1669-1688 6899 UGGAGGGGUAGUCGGUGGG
6900 UGGAGGGGuAGUCGGUGGGdTsdT antis 1682-1701 6901
CCUCCACGUCCAUCUGGGA 6902 ccuccAcGuccAucuGGGAdTsdT sense 1682-1701
6903 UCCCAGAUGGACGUGGAGG 6904 UCCcAGAUGGACGUGGAGGdTsdT antis
1685-1704 6905 CCACGUCCAUCUGGGAAGG 6906 ccAcGuccAucuGGGAAGGdTsdT
sense 1685-1704 6907 CCUUCCCAGAUGGACGUGG 6908
CCUUCCcAGAUGGACGUGGdTsdT antis 1704-1723 6909 CCCAAGUGGCGCUGGGAAG
6910 cccAAGuGGcGcuGGGAAGdTsdT sense 1704-1723 6911
CUUCCCAGCGCCACUUGGG 6912 CUUCCcAGCGCcACUUGGGdTsdT antis 1705-1724
6913 CCAAGUGGCGCUGGGAAGG 6914 ccAAGuGGcGcuGGGAAGGdTsdT sense
1705-1724 6915 CCUUCCCAGCGCCACUUGG 6916 CCUUCCcAGCGCcACUUGGdTsdT
antis 1730-1749 6917 CAGCCCAUCAAGCUCCUGC 6918
cAGcccAucAAGcuccuGcdTsdT sense 1730-1749 6919 GCAGGAGCUUGAUGGGCUG
6920 GcAGGAGCUUGAUGGGCUGdTsdT antis 1753-1772 6921
GCUGGGCCCCUAGACUAGA 6922 GcuGGGccccuAGAcuAGAdTsdT sense 1753-1772
6923 UCUAGUCUAGGGGCCCAGC 6924 UCuAGUCuAGGGGCCcAGCdTsdT antis
1759-1778 6925 CCCCUAGACUAGAGGGCAG 6926 ccccuAGAcuAGAGGGcAGdTsdT
sense 1759-1778 6927 CUGCCCUCUAGUCUAGGGG 6928
CUGCCCUCuAGUCuAGGGGdTsdT antis 1760-1779 6929 CCCUAGACUAGAGGGCAGA
6930 cccuAGAcuAGAGGGcAGAdTsdT sense 1760-1779 6931
UCUGCCCUCUAGUCUAGGG 6932 UCUGCCCUCuAGUCuAGGGdTsdT antis 1763-1782
6933 UAGACUAGAGGGCAGAGGU 6934 uAGAcuAGAGGGcAGAGGudTsdT sense
1763-1782 6935 ACCUCUGCCCUCUAGUCUA 6936 ACCUCUGCCCUCuAGUCuAdTsdT
antis 1773-1792 6937 GGCAGAGGUAAAUGAACUA 6938
GGcAGAGGuAAAuGAAcuAdTsdT sense 1773-1792 6939 UAGUUCAUUUACCUCUGCC
6940 uAGUUcAUUuACCUCUGCCdTsdT antis 1774-1793 6941
GCAGAGGUAAAUGAACUAC 6942 GcAGAGGuAAAuGAAcuAcdTsdT sense 1774-1793
6943 GUAGUUCAUUUACCUCUGC 6944 GuAGUUcAUUuACCUCUGCdTsdT antis
1782-1801 6945 AAAUGAACUACCCCCAGCA 6946 AAAuGAAcuAcccccAGcAdTsdT
sense 1782-1801 6947 UGCUGGGGGUAGUUCAUUU 6948
UGCUGGGGGuAGUUcAUUUdTsdT antis 1784-1803 6949 AUGAACUACCCCCAGCAUC
6950 AuGAAcuAcccccAGcAucdTsdT sense 1784-1803 6951
GAUGCUGGGGGUAGUUCAU 6952 GAUGCUGGGGGuAGUUcAUdTsdT antis 1785-1804
6953 UGAACUACCCCCAGCAUCU 6954 uGAAcuAcccccAGcAucudTsdT sense
1785-1804 6955 AGAUGCUGGGGGUAGUUCA 6956 AGAUGCUGGGGGuAGUUcAdTsdT
antis 1790-1809 6957 UACCCCCAGCAUCUAGGCC 6958
uAcccccAGcAucuAGGccdTsdT sense 1790-1809 6959 GGCCUAGAUGCUGGGGGUA
6960 GGCCuAGAUGCUGGGGGuAdTsdT antis 1794-1813 6961
CCCAGCAUCUAGGCCUCCC 6962 cccAGcAucuAGGccucccdTsdT sense 1794-1813
6963 GGGAGGCCUAGAUGCUGGG 6964 GGGAGGCCuAGAUGCUGGGdTsdT antis
1795-1814 6965 CCAGCAUCUAGGCCUCCCU 6966 ccAGcAucuAGGccucccudTsdT
sense 1795-1814 6967 AGGGAGGCCUAGAUGCUGG 6968
AGGGAGGCCuAGAUGCUGGdTsdT antis 1882-1901 6969 GGAAGGACGGGGUUUGGGG
6970 GGAAGGAcGGGGuuuGGGGdTsdT sense 1882-1901 6971
CCCCAAACCCCGUCCUUCC 6972 CCCcAAACCCCGUCCUUCCdTsdT antis 1883-1902
6973 GAAGGACGGGGUUUGGGGG 6974 GAAGGAcGGGGuuuGGGGGdTsdT sense
1883-1902 6975 CCCCCAAACCCCGUCCUUC 6976 CCCCcAAACCCCGUCCUUCdTsdT
antis 1913-1932 6977 UCUACCCCCUUGGUCCCCU 6978
ucuAcccccuuGGuccccudTsdT sense 1913-1932 6979 AGGGGACCAAGGGGGUAGA
6980 AGGGGACcAAGGGGGuAGAdTsdT antis 68-87 6981 CGGAGCCGGAGCCCGAACG
6982 cGGAGccGGAGcccGAAcGdTsdT sense 68-87 6983 CGUUCGGGCUCCGGCUCCG
6984 CGUUCGGGCUCCGGCUCCGdTsdT antis 117-136 6985
GAGGCGGCGGCAGAGGCAG 6986 GAGGcGGcGGcAGAGGcAGdTsdT sense 117-136
6987 CUGCCUCUGCCGCCGCCUC 6988 CUGCCUCUGCCGCCGCCUCdTsdT antis
188-207 6989 CGCCAUGAGCGGCGGCGGG 6990 cGccAuGAGcGGcGGcGGGdTsdT
sense 188-207 6991 CCCGCCGCCGCUCAUGGCG 6992
CCCGCCGCCGCUcAUGGCGdTsdT antis 219-238 6993 GGCCCUGGGGGCUCGGGCC
6994 GGcccuGGGGGcucGGGccdTsdT sense 219-238 6995
GGCCCGAGCCCCCAGGGCC 6996 GGCCCGAGCCCCcAGGGCCdTsdT antis 220-239
6997 GCCCUGGGGGCUCGGGCCG 6998 GcccuGGGGGcucGGGccGdTsdT sense
220-239 6999 CGGCCCGAGCCCCCAGGGC 7000 CGGCCCGAGCCCCcAGGGCdTsdT
antis 233-252 7001 GGGCCGGGCGCGGACCAGC 7002
GGGccGGGcGcGGAccAGcdTsdT sense 233-252 7003 GCUGGUCCGCGCCCGGCCC
7004 GCUGGUCCGCGCCCGGCCCdTsdT antis 237-256 7005
CGGGCGCGGACCAGCUCGU 7006 cGGGcGcGGAccAGcucGudTsdT sense 237-256
7007 ACGAGCUGGUCCGCGCCCG 7008 ACGAGCUGGUCCGCGCCCGdTsdT antis
308-327 7009 GGCCUCUGGCCCAGGAGGC 7010 GGccucuGGcccAGGAGGcdTsdT
sense 308-327 7011 GCCUCCUGGGCCAGAGGCC 7012
GCCUCCUGGGCcAGAGGCCdTsdT antis 311-330 7013 CUCUGGCCCAGGAGGCACU
7014 cucuGGcccAGGAGGcAcudTsdT sense 311-330 7015
AGUGCCUCCUGGGCCAGAG 7016 AGUGCCUCCUGGGCcAGAGdTsdT antis
351-370 7017 GGGGCUAUGGGUGGGGGCG 7018 GGGGcuAuGGGuGGGGGcGdTsdT
sense 351-370 7019 CGCCCCCACCCAUAGCCCC 7020
CGCCCCcACCcAuAGCCCCdTsdT antis 353-372 7021 GGCUAUGGGUGGGGGCGUG
7022 GGcuAuGGGuGGGGGcGuGdTsdT sense 353-372 7023
CACGCCCCCACCCAUAGCC 7024 cACGCCCCcACCcAuAGCCdTsdT antis 355-374
7025 CUAUGGGUGGGGGCGUGGG 7026 cuAuGGGuGGGGGcGuGGGdTsdT sense
355-374 7027 CCCACGCCCCCACCCAUAG 7028 CCcACGCCCCcACCcAuAGdTsdT
antis 357-376 7029 AUGGGUGGGGGCGUGGGAG 7030
AuGGGuGGGGGcGuGGGAGdTsdT sense 357-376 7031 CUCCCACGCCCCCACCCAU
7032 CUCCcACGCCCCcACCcAUdTsdT antis 361-380 7033
GUGGGGGCGUGGGAGCCUC 7034 GuGGGGGcGuGGGAGccucdTsdT sense 361-380
7035 GAGGCUCCCACGCCCCCAC 7036 GAGGCUCCcACGCCCCcACdTsdT antis
363-382 7037 GGGGGCGUGGGAGCCUCGA 7038 GGGGGcGuGGGAGccucGAdTsdT
sense 363-382 7039 UCGAGGCUCCCACGCCCCC 7040
UCGAGGCUCCcACGCCCCCdTsdT antis 364-383 7041 GGGGCGUGGGAGCCUCGAG
7042 GGGGcGuGGGAGccucGAGdTsdT sense 364-383 7043
CUCGAGGCUCCCACGCCCC 7044 CUCGAGGCUCCcACGCCCCdTsdT antis 365-384
7045 GGGCGUGGGAGCCUCGAGC 7046 GGGcGuGGGAGccucGAGcdTsdT sense
365-384 7047 GCUCGAGGCUCCCACGCCC 7048 GCUCGAGGCUCCcACGCCCdTsdT
antis 366-385 7049 GGCGUGGGAGCCUCGAGCU 7050
GGcGuGGGAGccucGAGcudTsdT sense 366-385 7051 AGCUCGAGGCUCCCACGCC
7052 AGCUCGAGGCUCCcACGCCdTsdT antis 368-387 7053
CGUGGGAGCCUCGAGCUCC 7054 cGuGGGAGccucGAGcuccdTsdT sense 368-387
7055 GGAGCUCGAGGCUCCCACG 7056 GGAGCUCGAGGCUCCcACGdTsdT antis
485-504 7057 GAAGGUGACCACAGUGGUA 7058 GAAGGuGAccAcAGuGGuAdTsdT
sense 485-504 7059 UACCACUGUGGUCACCUUC 7060
uACcACUGUGGUcACCUUCdTsdT antis 487-506 7061 AGGUGACCACAGUGGUAGC
7062 AGGuGAccAcAGuGGuAGcdTsdT sense 487-506 7063
GCUACCACUGUGGUCACCU 7064 GCuACcACUGUGGUcACCUdTsdT antis 488-507
7065 GGUGACCACAGUGGUAGCC 7066 GGuGAccAcAGuGGuAGccdTsdT sense
488-507 7067 GGCUACCACUGUGGUCACC 7068 GGCuACcACUGUGGUcACCdTsdT
antis 547-566 7069 ACACUGACAUCAAAGUGAU 7070
AcAcuGAcAucAAAGuGAudTsdT sense 547-566 7071 AUCACUUUGAUGUCAGUGU
7072 AUcACUUUGAUGUcAGUGUdTsdT antis 548-567 7073
CACUGACAUCAAAGUGAUU 7074 cAcuGAcAucAAAGuGAuudTsdT sense 548-567
7075 AAUCACUUUGAUGUCAGUG 7076 AAUcACUUUGAUGUcAGUGdTsdT antis
551-570 7077 UGACAUCAAAGUGAUUGGU 7078 uGAcAucAAAGuGAuuGGudTsdT
sense 551-570 7079 ACCAAUCACUUUGAUGUCA 7080
ACcAAUcACUUUGAUGUcAdTsdT antis 552-571 7081 GACAUCAAAGUGAUUGGUA
7082 GAcAucAAAGuGAuuGGuAdTsdT sense 552-571 7083
UACCAAUCACUUUGAUGUC 7084 uACcAAUcACUUUGAUGUCdTsdT antis 553-572
7085 ACAUCAAAGUGAUUGGUAA 7086 AcAucAAAGuGAuuGGuAAdTsdT sense
553-572 7087 UUACCAAUCACUUUGAUGU 7088 UuACcAAUcACUUUGAUGUdTsdT
antis 554-573 7089 CAUCAAAGUGAUUGGUAAU 7090
cAucAAAGuGAuuGGuAAudTsdT sense 554-573 7091 AUUACCAAUCACUUUGAUG
7092 AUuACcAAUcACUUUGAUGdTsdT antis 556-575 7093
UCAAAGUGAUUGGUAAUGG 7094 ucAAAGuGAuuGGuAAuGGdTsdT sense 556-575
7095 CCAUUACCAAUCACUUUGA 7096 CcAUuACcAAUcACUUUGAdTsdT antis
557-576 7097 CAAAGUGAUUGGUAAUGGC 7098 cAAAGuGAuuGGuAAuGGcdTsdT
sense 557-576 7099 GCCAUUACCAAUCACUUUG 7100
GCcAUuACcAAUcACUUUGdTsdT antis 562-581 7101 UGAUUGGUAAUGGCUCAUU
7102 uGAuuGGuAAuGGcucAuudTsdT sense 562-581 7103
AAUGAGCCAUUACCAAUCA 7104 AAUGAGCcAUuACcAAUcAdTsdT antis 563-582
7105 GAUUGGUAAUGGCUCAUUC 7106 GAuuGGuAAuGGcucAuucdTsdT sense
563-582 7107 GAAUGAGCCAUUACCAAUC 7108 GAAUGAGCcAUuACcAAUCdTsdT
antis 564-583 7109 AUUGGUAAUGGCUCAUUCG 7110
AuuGGuAAuGGcucAuucGdTsdT sense 564-583 7111 CGAAUGAGCCAUUACCAAU
7112 CGAAUGAGCcAUuACcAAUdTsdT antis 565-584 7113
UUGGUAAUGGCUCAUUCGG 7114 uuGGuAAuGGcucAuucGGdTsdT sense 565-584
7115 CCGAAUGAGCCAUUACCAA 7116 CCGAAUGAGCcAUuACcAAdTsdT antis
566-585 7117 UGGUAAUGGCUCAUUCGGA 7118 uGGuAAuGGcucAuucGGAdTsdT
sense 566-585 7119 UCCGAAUGAGCCAUUACCA 7120
UCCGAAUGAGCcAUuACcAdTsdT antis 627-646 7121 GCCAUCAAGAAGGUUCUUC
7122 GccAucAAGAAGGuucuucdTsdT sense 627-646 7123
GAAGAACCUUCUUGAUGGC 7124 GAAGAACCUUCUUGAUGGCdTsdT antis 631-650
7125 UCAAGAAGGUUCUUCAGGA 7126 ucAAGAAGGuucuucAGGAdTsdT sense
631-650 7127 UCCUGAAGAACCUUCUUGA 7128 UCCUGAAGAACCUUCUUGAdTsdT
antis 632-651 7129 CAAGAAGGUUCUUCAGGAC 7130
cAAGAAGGuucuucAGGAcdTsdT sense 632-651 7131 GUCCUGAAGAACCUUCUUG
7132 GUCCUGAAGAACCUUCUUGdTsdT antis 634-653 7133
AGAAGGUUCUUCAGGACAA 7134 AGAAGGuucuucAGGAcAAdTsdT sense 634-653
7135 UUGUCCUGAAGAACCUUCU 7136 UUGUCCUGAAGAACCUUCUdTsdT antis
635-654 7137 GAAGGUUCUUCAGGACAAA 7138 GAAGGuucuucAGGAcAAAdTsdT
sense 635-654 7139 UUUGUCCUGAAGAACCUUC 7140
UUUGUCCUGAAGAACCUUCdTsdT antis 638-657 7141 GGUUCUUCAGGACAAAAGG
7142 GGuucuucAGGAcAAAAGGdTsdT sense 638-657 7143
CCUUUUGUCCUGAAGAACC 7144 CCUUUUGUCCUGAAGAACCdTsdT antis 639-658
7145 GUUCUUCAGGACAAAAGGU 7146 GuucuucAGGAcAAAAGGudTsdT sense
639-658 7147 ACCUUUUGUCCUGAAGAAC 7148 ACCUUUUGUCCUGAAGAACdTsdT
antis 640-659 7149 UUCUUCAGGACAAAAGGUU 7150
uucuucAGGAcAAAAGGuudTsdT sense 640-659 7151 AACCUUUUGUCCUGAAGAA
7152 AACCUUUUGUCCUGAAGAAdTsdT antis 641-660 7153
UCUUCAGGACAAAAGGUUC 7154 ucuucAGGAcAAAAGGuucdTsdT sense 641-660
7155 GAACCUUUUGUCCUGAAGA 7156 GAACCUUUUGUCCUGAAGAdTsdT antis
642-661 7157 CUUCAGGACAAAAGGUUCA 7158 cuucAGGAcAAAAGGuucAdTsdT
sense 642-661 7159 UGAACCUUUUGUCCUGAAG 7160
UGAACCUUUUGUCCUGAAGdTsdT antis 643-662 7161 UUCAGGACAAAAGGUUCAA
7162 uucAGGAcAAAAGGuucAAdTsdT sense 643-662 7163
UUGAACCUUUUGUCCUGAA 7164 UUGAACCUUUUGUCCUGAAdTsdT antis 644-663
7165 UCAGGACAAAAGGUUCAAG 7166 ucAGGAcAAAAGGuucAAGdTsdT sense
644-663 7167 CUUGAACCUUUUGUCCUGA 7168 CUUGAACCUUUUGUCCUGAdTsdT
antis 645-664 7169 CAGGACAAAAGGUUCAAGA 7170
cAGGAcAAAAGGuucAAGAdTsdT sense 645-664 7171 UCUUGAACCUUUUGUCCUG
7172 UCUUGAACCUUUUGUCCUGdTsdT antis 686-705 7173
UAAGCUGGACCACUGCAAU 7174 uAAGcuGGAccAcuGcAAudTsdT sense 686-705
7175 AUUGCAGUGGUCCAGCUUA 7176 AUUGcAGUGGUCcAGCUuAdTsdT antis
687-706 7177 AAGCUGGACCACUGCAAUA 7178 AAGcuGGAccAcuGcAAuAdTsdT
sense 687-706 7179 UAUUGCAGUGGUCCAGCUU 7180
uAUUGcAGUGGUCcAGCUUdTsdT antis 689-708 7181 GCUGGACCACUGCAAUAUU
7182 GcuGGAccAcuGcAAuAuudTsdT sense 689-708 7183
AAUAUUGCAGUGGUCCAGC 7184 AAuAUUGcAGUGGUCcAGCdTsdT antis 690-709
7185 CUGGACCACUGCAAUAUUG 7186 cuGGAccAcuGcAAuAuuGdTsdT sense
690-709 7187 CAAUAUUGCAGUGGUCCAG 7188 cAAuAUUGcAGUGGUCcAGdTsdT
antis 691-710 7189 UGGACCACUGCAAUAUUGU 7190
uGGAccAcuGcAAuAuuGudTsdT sense 691-710 7191 ACAAUAUUGCAGUGGUCCA
7192 AcAAuAUUGcAGUGGUCcAdTsdT antis 692-711 7193
GGACCACUGCAAUAUUGUG 7194 GGAccAcuGcAAuAuuGuGdTsdT sense 692-711
7195 CACAAUAUUGCAGUGGUCC 7196 cAcAAuAUUGcAGUGGUCCdTsdT antis
694-713 7197 ACCACUGCAAUAUUGUGAG 7198 AccAcuGcAAuAuuGuGAGdTsdT
sense 694-713 7199 CUCACAAUAUUGCAGUGGU 7200
CUcAcAAuAUUGcAGUGGUdTsdT antis 696-715 7201 CACUGCAAUAUUGUGAGGC
7202 cAcuGcAAuAuuGuGAGGcdTsdT sense 696-715 7203
GCCUCACAAUAUUGCAGUG 7204 GCCUcAcAAuAUUGcAGUGdTsdT antis 698-717
7205 CUGCAAUAUUGUGAGGCUG 7206 cuGcAAuAuuGuGAGGcuGdTsdT sense
698-717 7207 CAGCCUCACAAUAUUGCAG 7208 cAGCCUcAcAAuAUUGcAGdTsdT
antis 699-718 7209 UGCAAUAUUGUGAGGCUGC 7210
uGcAAuAuuGuGAGGcuGcdTsdT sense 699-718 7211 GCAGCCUCACAAUAUUGCA
7212 GcAGCCUcAcAAuAUUGcAdTsdT antis 718-737 7213
GGUACUUUUUCUACUCCAG 7214 GGuAcuuuuucuAcuccAGdTsdT sense 718-737
7215 CUGGAGUAGAAAAAGUACC 7216 CUGGAGuAGAAAAAGuACCdTsdT antis
720-739 7217 UACUUUUUCUACUCCAGUG 7218 uAcuuuuucuAcuccAGuGdTsdT
sense 720-739 7219 CACUGGAGUAGAAAAAGUA 7220
cACUGGAGuAGAAAAAGuAdTsdT antis 721-740 7221 ACUUUUUCUACUCCAGUGG
7222 AcuuuuucuAcuccAGuGGdTsdT sense 721-740 7223
CCACUGGAGUAGAAAAAGU 7224 CcACUGGAGuAGAAAAAGUdTsdT antis 723-742
7225 UUUUUCUACUCCAGUGGGG 7226 uuuuucuAcuccAGuGGGGdTsdT sense
723-742 7227 CCCCACUGGAGUAGAAAAA 7228 CCCcACUGGAGuAGAAAAAdTsdT
antis 729-748 7229 UACUCCAGUGGGGAGAAGA 7230
uAcuccAGuGGGGAGAAGAdTsdT sense 729-748 7231 UCUUCUCCCCACUGGAGUA
7232 UCUUCUCCCcACUGGAGuAdTsdT antis 730-749 7233
ACUCCAGUGGGGAGAAGAA 7234 AcuccAGuGGGGAGAAGAAdTsdT sense 730-749
7235 UUCUUCUCCCCACUGGAGU 7236 UUCUUCUCCCcACUGGAGUdTsdT antis
736-755 7237 GUGGGGAGAAGAAGGACGA 7238 GuGGGGAGAAGAAGGAcGAdTsdT
sense 736-755 7239 UCGUCCUUCUUCUCCCCAC 7240
UCGUCCUUCUUCUCCCcACdTsdT antis 737-756 7241 UGGGGAGAAGAAGGACGAG
7242 uGGGGAGAAGAAGGAcGAGdTsdT sense 737-756 7243
CUCGUCCUUCUUCUCCCCA 7244 CUCGUCCUUCUUCUCCCcAdTsdT antis 755-774
7245 GCUGUAUUUGAAUCUGGUG 7246 GcuGuAuuuGAAucuGGuGdTsdT sense
755-774 7247 CACCAGAUUCAAAUACAGC 7248 cACcAGAUUcAAAuAcAGCdTsdT
antis 756-775 7249 CUGUAUUUGAAUCUGGUGC 7250
cuGuAuuuGAAucuGGuGcdTsdT sense 756-775 7251 GCACCAGAUUCAAAUACAG
7252 GcACcAGAUUcAAAuAcAGdTsdT antis 758-777 7253
GUAUUUGAAUCUGGUGCUG 7254 GuAuuuGAAucuGGuGcuGdTsdT sense 758-777
7255 CAGCACCAGAUUCAAAUAC 7256 cAGcACcAGAUUcAAAuACdTsdT antis
761-780 7257 UUUGAAUCUGGUGCUGGAG 7258 uuuGAAucuGGuGcuGGAGdTsdT
sense 761-780 7259 CUCCAGCACCAGAUUCAAA 7260
CUCcAGcACcAGAUUcAAAdTsdT antis 765-784 7261 AAUCUGGUGCUGGAGUAUG
7262 AAucuGGuGcuGGAGuAuGdTsdT sense 765-784 7263
CAUACUCCAGCACCAGAUU 7264 cAuACUCcAGcACcAGAUUdTsdT antis 769-788
7265 UGGUGCUGGAGUAUGUGCC 7266 uGGuGcuGGAGuAuGuGccdTsdT sense
769-788 7267 GGCACAUACUCCAGCACCA 7268 GGcAcAuACUCcAGcACcAdTsdT
antis 770-789 7269 GGUGCUGGAGUAUGUGCCC 7270
GGuGcuGGAGuAuGuGcccdTsdT sense 770-789 7271 GGGCACAUACUCCAGCACC
7272 GGGcAcAuACUCcAGcACCdTsdT antis 771-790 7273
GUGCUGGAGUAUGUGCCCG 7274 GuGcuGGAGuAuGuGcccGdTsdT sense 771-790
7275 CGGGCACAUACUCCAGCAC 7276 CGGGcAcAuACUCcAGcACdTsdT antis
772-791 7277 UGCUGGAGUAUGUGCCCGA 7278 uGcuGGAGuAuGuGcccGAdTsdT
sense 772-791 7279 UCGGGCACAUACUCCAGCA 7280
UCGGGcAcAuACUCcAGcAdTsdT antis 773-792 7281 GCUGGAGUAUGUGCCCGAG
7282 GcuGGAGuAuGuGcccGAGdTsdT sense 773-792 7283
CUCGGGCACAUACUCCAGC 7284 CUCGGGcAcAuACUCcAGCdTsdT antis 774-793
7285 CUGGAGUAUGUGCCCGAGA 7286 cuGGAGuAuGuGcccGAGAdTsdT sense
774-793 7287 UCUCGGGCACAUACUCCAG 7288 UCUCGGGcAcAuACUCcAGdTsdT
antis 781-800 7289 AUGUGCCCGAGACGGUGUA 7290
AuGuGcccGAGAcGGuGuAdTsdT sense 781-800 7291 UACACCGUCUCGGGCACAU
7292 uAcACCGUCUCGGGcAcAUdTsdT antis 782-801 7293
UGUGCCCGAGACGGUGUAC 7294 uGuGcccGAGAcGGuGuAcdTsdT sense 782-801
7295 GUACACCGUCUCGGGCACA 7296 GuAcACCGUCUCGGGcAcAdTsdT antis
803-822 7297 AGUGGCCCGCCACUUCACC 7298 AGuGGcccGccAcuucAccdTsdT
sense 803-822 7299 GGUGAAGUGGCGGGCCACU 7300
GGUGAAGUGGCGGGCcACUdTsdT antis 804-823 7301 GUGGCCCGCCACUUCACCA
7302 GuGGcccGccAcuucAccAdTsdT sense 804-823 7303
UGGUGAAGUGGCGGGCCAC 7304 UGGUGAAGUGGCGGGCcACdTsdT antis 805-824
7305 UGGCCCGCCACUUCACCAA 7306 uGGcccGccAcuucAccAAdTsdT sense
805-824 7307 UUGGUGAAGUGGCGGGCCA 7308 UUGGUGAAGUGGCGGGCcAdTsdT
antis 806-825 7309 GGCCCGCCACUUCACCAAG 7310
GGcccGccAcuucAccAAGdTsdT sense 806-825 7311 CUUGGUGAAGUGGCGGGCC
7312 CUUGGUGAAGUGGCGGGCCdTsdT antis 807-826 7313
GCCCGCCACUUCACCAAGG 7314 GcccGccAcuucAccAAGGdTsdT sense 807-826
7315 CCUUGGUGAAGUGGCGGGC 7316 CCUUGGUGAAGUGGCGGGCdTsdT antis
808-827 7317 CCCGCCACUUCACCAAGGC 7318 cccGccAcuucAccAAGGcdTsdT
sense 808-827 7319 GCCUUGGUGAAGUGGCGGG 7320
GCCUUGGUGAAGUGGCGGGdTsdT antis 809-828 7321 CCGCCACUUCACCAAGGCC
7322 ccGccAcuucAccAAGGccdTsdT sense 809-828 7323
GGCCUUGGUGAAGUGGCGG 7324 GGCCUUGGUGAAGUGGCGGdTsdT antis 810-829
7325 CGCCACUUCACCAAGGCCA 7326 cGccAcuucAccAAGGccAdTsdT sense
810-829 7327 UGGCCUUGGUGAAGUGGCG 7328 UGGCCUUGGUGAAGUGGCGdTsdT
antis 811-830 7329 GCCACUUCACCAAGGCCAA 7330
GccAcuucAccAAGGccAAdTsdT sense 811-830 7331 UUGGCCUUGGUGAAGUGGC
7332 UUGGCCUUGGUGAAGUGGCdTsdT antis 813-832 7333
CACUUCACCAAGGCCAAGC 7334 cAcuucAccAAGGccAAGcdTsdT sense 813-832
7335 GCUUGGCCUUGGUGAAGUG 7336 GCUUGGCCUUGGUGAAGUGdTsdT antis
815-834 7337 CUUCACCAAGGCCAAGCUG 7338 cuucAccAAGGccAAGcuGdTsdT
sense 815-834 7339 CAGCUUGGCCUUGGUGAAG 7340
cAGCUUGGCCUUGGUGAAGdTsdT antis 817-836 7341 UCACCAAGGCCAAGCUGAU
7342 ucAccAAGGccAAGcuGAudTsdT sense 817-836 7343
AUCAGCUUGGCCUUGGUGA 7344 AUcAGCUUGGCCUUGGUGAdTsdT antis 858-877
7345 GUGUACAUGUACCAGCUCU 7346 GuGuAcAuGuAccAGcucudTsdT sense
858-877 7347 AGAGCUGGUACAUGUACAC 7348 AGAGCUGGuAcAUGuAcACdTsdT
antis 860-879 7349 GUACAUGUACCAGCUCUUC 7350
GuAcAuGuAccAGcucuucdTsdT sense 860-879 7351 GAAGAGCUGGUACAUGUAC
7352 GAAGAGCUGGuAcAUGuACdTsdT antis 861-880 7353
UACAUGUACCAGCUCUUCC 7354 uAcAuGuAccAGcucuuccdTsdT sense 861-880
7355 GGAAGAGCUGGUACAUGUA 7356 GGAAGAGCUGGuAcAUGuAdTsdT antis
862-881 7357 ACAUGUACCAGCUCUUCCG 7358 AcAuGuAccAGcucuuccGdTsdT
sense 862-881 7359 CGGAAGAGCUGGUACAUGU 7360
CGGAAGAGCUGGuAcAUGUdTsdT antis 863-882 7361 CAUGUACCAGCUCUUCCGG
7362 cAuGuAccAGcucuuccGGdTsdT sense 863-882 7363
CCGGAAGAGCUGGUACAUG 7364 CCGGAAGAGCUGGuAcAUGdTsdT antis 865-884
7365 UGUACCAGCUCUUCCGGAG 7366 uGuAccAGcucuuccGGAGdTsdT sense
865-884 7367 CUCCGGAAGAGCUGGUACA 7368 CUCCGGAAGAGCUGGuAcAdTsdT
antis 866-885 7369 GUACCAGCUCUUCCGGAGC 7370
GuAccAGcucuuccGGAGcdTsdT sense 866-885 7371 GCUCCGGAAGAGCUGGUAC
7372 GCUCCGGAAGAGCUGGuACdTsdT antis 867-886 7373
UACCAGCUCUUCCGGAGCU 7374 uAccAGcucuuccGGAGcudTsdT sense 867-886
7375 AGCUCCGGAAGAGCUGGUA 7376 AGCUCCGGAAGAGCUGGuAdTsdT antis
868-887 7377 ACCAGCUCUUCCGGAGCUU 7378 AccAGcucuuccGGAGcuudTsdT
sense 868-887 7379 AAGCUCCGGAAGAGCUGGU 7380
AAGCUCCGGAAGAGCUGGUdTsdT antis 869-888 7381 CCAGCUCUUCCGGAGCUUG
7382 ccAGcucuuccGGAGcuuGdTsdT sense 869-888 7383
CAAGCUCCGGAAGAGCUGG 7384 cAAGCUCCGGAAGAGCUGGdTsdT antis 870-889
7385 CAGCUCUUCCGGAGCUUGG 7386 cAGcucuuccGGAGcuuGGdTsdT sense
870-889 7387 CCAAGCUCCGGAAGAGCUG 7388 CcAAGCUCCGGAAGAGCUGdTsdT
antis 871-890 7389 AGCUCUUCCGGAGCUUGGC 7390
AGcucuuccGGAGcuuGGcdTsdT sense 871-890 7391 GCCAAGCUCCGGAAGAGCU
7392 GCcAAGCUCCGGAAGAGCUdTsdT antis 872-891 7393
GCUCUUCCGGAGCUUGGCC 7394 GcucuuccGGAGcuuGGccdTsdT sense 872-891
7395 GGCCAAGCUCCGGAAGAGC 7396 GGCcAAGCUCCGGAAGAGCdTsdT antis
874-893 7397 UCUUCCGGAGCUUGGCCUA 7398 ucuuccGGAGcuuGGccuAdTsdT
sense 874-893 7399 UAGGCCAAGCUCCGGAAGA 7400
uAGGCcAAGCUCCGGAAGAdTsdT antis 876-895 7401 UUCCGGAGCUUGGCCUACA
7402 uuccGGAGcuuGGccuAcAdTsdT sense 876-895 7403
UGUAGGCCAAGCUCCGGAA 7404 UGuAGGCcAAGCUCCGGAAdTsdT antis 877-896
7405 UCCGGAGCUUGGCCUACAU 7406 uccGGAGcuuGGccuAcAudTsdT sense
877-896 7407 AUGUAGGCCAAGCUCCGGA 7408 AUGuAGGCcAAGCUCCGGAdTsdT
antis 878-897 7409 CCGGAGCUUGGCCUACAUC 7410
ccGGAGcuuGGccuAcAucdTsdT sense 878-897 7411 GAUGUAGGCCAAGCUCCGG
7412 GAUGuAGGCcAAGCUCCGGdTsdT antis 911-930 7413
GUGUCACCGUGACAUCAAG 7414 GuGucAccGuGAcAucAAGdTsdT sense 911-930
7415 CUUGAUGUCACGGUGACAC 7416 CUUGAUGUcACGGUGAcACdTsdT antis
935-954 7417 GAAUUUGCUUGUGGACCCU 7418 GAAuuuGcuuGuGGAcccudTsdT
sense 935-954 7419 AGGGUCCACAAGCAAAUUC 7420
AGGGUCcAcAAGcAAAUUCdTsdT antis 939-958 7421 UUGCUUGUGGACCCUGACA
7422 uuGcuuGuGGAcccuGAcAdTsdT sense 939-958 7423
UGUCAGGGUCCACAAGCAA 7424 UGUcAGGGUCcAcAAGcAAdTsdT antis 940-959
7425 UGCUUGUGGACCCUGACAC 7426 uGcuuGuGGAcccuGAcAcdTsdT sense
940-959 7427 GUGUCAGGGUCCACAAGCA 7428 GUGUcAGGGUCcAcAAGcAdTsdT
antis 941-960 7429 GCUUGUGGACCCUGACACU 7430
GcuuGuGGAcccuGAcAcudTsdT sense 941-960 7431 AGUGUCAGGGUCCACAAGC
7432 AGUGUcAGGGUCcAcAAGCdTsdT antis 943-962 7433
UUGUGGACCCUGACACUGC 7434 uuGuGGAcccuGAcAcuGcdTsdT sense 943-962
7435 GCAGUGUCAGGGUCCACAA 7436 GcAGUGUcAGGGUCcAcAAdTsdT antis
949-968 7437 ACCCUGACACUGCUGUCCU 7438 AcccuGAcAcuGcuGuccudTsdT
sense 949-968 7439 AGGACAGCAGUGUCAGGGU 7440
AGGAcAGcAGUGUcAGGGUdTsdT antis 952-971 7441 CUGACACUGCUGUCCUCAA
7442 cuGAcAcuGcuGuccucAAdTsdT sense 952-971 7443
UUGAGGACAGCAGUGUCAG 7444 UUGAGGAcAGcAGUGUcAGdTsdT antis 970-989
7445 AGCUCUGCGAUUUUGGCAG 7446 AGcucuGcGAuuuuGGcAGdTsdT sense
970-989 7447 CUGCCAAAAUCGCAGAGCU 7448 CUGCcAAAAUCGcAGAGCUdTsdT
antis 974-993 7449 CUGCGAUUUUGGCAGUGCA 7450
cuGcGAuuuuGGcAGuGcAdTsdT sense 974-993 7451 UGCACUGCCAAAAUCGCAG
7452 UGcACUGCcAAAAUCGcAGdTsdT antis 977-996 7453
CGAUUUUGGCAGUGCAAAG 7454 cGAuuuuGGcAGuGcAAAGdTsdT sense 977-996
7455 CUUUGCACUGCCAAAAUCG 7456 CUUUGcACUGCcAAAAUCGdTsdT antis
978-997 7457 GAUUUUGGCAGUGCAAAGC 7458 GAuuuuGGcAGuGcAAAGcdTsdT
sense 978-997 7459 GCUUUGCACUGCCAAAAUC 7460
GCUUUGcACUGCcAAAAUCdTsdT antis 986-1005 7461 CAGUGCAAAGCAGCUGGUU
7462 cAGuGcAAAGcAGcuGGuudTsdT sense 986-1005 7463
AACCAGCUGCUUUGCACUG 7464 AACcAGCUGCUUUGcACUGdTsdT antis 987-1006
7465 AGUGCAAAGCAGCUGGUUC 7466 AGuGcAAAGcAGcuGGuucdTsdT sense
987-1006 7467 GAACCAGCUGCUUUGCACU 7468 GAACcAGCUGCUUUGcACUdTsdT
antis 988-1007 7469 GUGCAAAGCAGCUGGUUCG 7470
GuGcAAAGcAGcuGGuucGdTsdT sense 988-1007 7471 CGAACCAGCUGCUUUGCAC
7472 CGAACcAGCUGCUUUGcACdTsdT antis 1162-1181 7473
GUGGGGUGGACCAGCUUGU 7474 GuGGGGuGGAccAGcuuGudTsdT sense 1162-1181
7475 ACAAGCUGGUCCACCCCAC 7476 AcAAGCUGGUCcACCCcACdTsdT antis
1163-1182 7477 UGGGGUGGACCAGCUUGUG 7478 uGGGGuGGAccAGcuuGuGdTsdT
sense 1163-1182 7479 CACAAGCUGGUCCACCCCA 7480
cAcAAGCUGGUCcACCCcAdTsdT antis 1164-1183 7481 GGGGUGGACCAGCUUGUGG
7482 GGGGuGGAccAGcuuGuGGdTsdT sense 1164-1183 7483
CCACAAGCUGGUCCACCCC 7484 CcAcAAGCUGGUCcACCCCdTsdT antis 1165-1184
7485 GGGUGGACCAGCUUGUGGA 7486 GGGuGGAccAGcuuGuGGAdTsdT sense
1165-1184 7487 UCCACAAGCUGGUCCACCC 7488 UCcAcAAGCUGGUCcACCCdTsdT
antis 1168-1187 7489 UGGACCAGCUUGUGGAGAU 7490
uGGAccAGcuuGuGGAGAudTsdT sense 1168-1187 7491 AUCUCCACAAGCUGGUCCA
7492 AUCUCcAcAAGCUGGUCcAdTsdT antis 1172-1191 7493
CCAGCUUGUGGAGAUCAUC 7494 ccAGcuuGuGGAGAucAucdTsdT sense 1172-1191
7495 GAUGAUCUCCACAAGCUGG 7496 GAUGAUCUCcAcAAGCUGGdTsdT antis
1173-1192 7497 CAGCUUGUGGAGAUCAUCA 7498 cAGcuuGuGGAGAucAucAdTsdT
sense 1173-1192 7499 UGAUGAUCUCCACAAGCUG 7500
UGAUGAUCUCcAcAAGCUGdTsdT antis 1175-1194 7501 GCUUGUGGAGAUCAUCAAG
7502 GcuuGuGGAGAucAucAAGdTsdT sense 1175-1194 7503
CUUGAUGAUCUCCACAAGC 7504 CUUGAUGAUCUCcAcAAGCdTsdT antis 1176-1195
7505 CUUGUGGAGAUCAUCAAGG 7506 cuuGuGGAGAucAucAAGGdTsdT sense
1176-1195 7507 CCUUGAUGAUCUCCACAAG 7508 CCUUGAUGAUCUCcAcAAGdTsdT
antis 1177-1196 7509 UUGUGGAGAUCAUCAAGGU 7510
uuGuGGAGAucAucAAGGudTsdT sense 1177-1196 7511 ACCUUGAUGAUCUCCACAA
7512 ACCUUGAUGAUCUCcAcAAdTsdT antis 1179-1198 7513
GUGGAGAUCAUCAAGGUAC 7514 GuGGAGAucAucAAGGuAcdTsdT sense 1179-1198
7515 GUACCUUGAUGAUCUCCAC 7516 GuACCUUGAUGAUCUCcACdTsdT antis
1180-1199 7517 UGGAGAUCAUCAAGGUACU 7518 uGGAGAucAucAAGGuAcudTsdT
sense
1180-1199 7519 AGUACCUUGAUGAUCUCCA 7520 AGuACCUUGAUGAUCUCcAdTsdT
antis 1181-1200 7521 GGAGAUCAUCAAGGUACUA 7522
GGAGAucAucAAGGuAcuAdTsdT sense 1181-1200 7523 UAGUACCUUGAUGAUCUCC
7524 uAGuACCUUGAUGAUCUCCdTsdT antis 1182-1201 7525
GAGAUCAUCAAGGUACUAG 7526 GAGAucAucAAGGuAcuAGdTsdT sense 1182-1201
7527 CUAGUACCUUGAUGAUCUC 7528 CuAGuACCUUGAUGAUCUCdTsdT antis
1184-1203 7529 GAUCAUCAAGGUACUAGGA 7530 GAucAucAAGGuAcuAGGAdTsdT
sense 1184-1203 7531 UCCUAGUACCUUGAUGAUC 7532
UCCuAGuACCUUGAUGAUCdTsdT antis 1186-1205 7533 UCAUCAAGGUACUAGGAAC
7534 ucAucAAGGuAcuAGGAAcdTsdT sense 1186-1205 7535
GUUCCUAGUACCUUGAUGA 7536 GUUCCuAGuACCUUGAUGAdTsdT antis 1187-1206
7537 CAUCAAGGUACUAGGAACG 7538 cAucAAGGuAcuAGGAAcGdTsdT sense
1187-1206 7539 CGUUCCUAGUACCUUGAUG 7540 CGUUCCuAGuACCUUGAUGdTsdT
antis 1205-1224 7541 GCCAACCAGGGAACAAAUC 7542
GccAAccAGGGAAcAAAucdTsdT sense 1205-1224 7543 GAUUUGUUCCCUGGUUGGC
7544 GAUUUGUUCCCUGGUUGGCdTsdT antis 1207-1226 7545
CAACCAGGGAACAAAUCCG 7546 cAAccAGGGAAcAAAuccGdTsdT sense 1207-1226
7547 CGGAUUUGUUCCCUGGUUG 7548 CGGAUUUGUUCCCUGGUUGdTsdT antis
1209-1228 7549 ACCAGGGAACAAAUCCGAG 7550 AccAGGGAAcAAAuccGAGdTsdT
sense 1209-1228 7551 CUCGGAUUUGUUCCCUGGU 7552
CUCGGAUUUGUUCCCUGGUdTsdT antis 1212-1231 7553 AGGGAACAAAUCCGAGAGA
7554 AGGGAAcAAAuccGAGAGAdTsdT sense 1212-1231 7555
UCUCUCGGAUUUGUUCCCU 7556 UCUCUCGGAUUUGUUCCCUdTsdT antis 1214-1233
7557 GGAACAAAUCCGAGAGAUG 7558 GGAAcAAAuccGAGAGAuGdTsdT sense
1214-1233 7559 CAUCUCUCGGAUUUGUUCC 7560 cAUCUCUCGGAUUUGUUCCdTsdT
antis 1219-1238 7561 AAAUCCGAGAGAUGAACCC 7562
AAAuccGAGAGAuGAAcccdTsdT sense 1219-1238 7563 GGGUUCAUCUCUCGGAUUU
7564 GGGUUcAUCUCUCGGAUUUdTsdT antis 1222-1241 7565
UCCGAGAGAUGAACCCUAA 7566 uccGAGAGAuGAAcccuAAdTsdT sense 1222-1241
7567 UUAGGGUUCAUCUCUCGGA 7568 UuAGGGUUcAUCUCUCGGAdTsdT antis
1223-1242 7569 CCGAGAGAUGAACCCUAAC 7570 ccGAGAGAuGAAcccuAAcdTsdT
sense 1223-1242 7571 GUUAGGGUUCAUCUCUCGG 7572
GUuAGGGUUcAUCUCUCGGdTsdT antis 1247-1266 7573 GGAGUUCAAGUUCCCCCAG
7574 GGAGuucAAGuucccccAGdTsdT sense 1247-1266 7575
CUGGGGGAACUUGAACUCC 7576 CUGGGGGAACUUGAACUCCdTsdT antis 1248-1267
7577 GAGUUCAAGUUCCCCCAGA 7578 GAGuucAAGuucccccAGAdTsdT sense
1248-1267 7579 UCUGGGGGAACUUGAACUC 7580 UCUGGGGGAACUUGAACUCdTsdT
antis 1249-1268 7581 AGUUCAAGUUCCCCCAGAU 7582
AGuucAAGuucccccAGAudTsdT sense 1249-1268 7583 AUCUGGGGGAACUUGAACU
7584 AUCUGGGGGAACUUGAACUdTsdT antis 1250-1269 7585
GUUCAAGUUCCCCCAGAUC 7586 GuucAAGuucccccAGAucdTsdT sense 1250-1269
7587 GAUCUGGGGGAACUUGAAC 7588 GAUCUGGGGGAACUUGAACdTsdT antis
1251-1270 7589 UUCAAGUUCCCCCAGAUCA 7590 uucAAGuucccccAGAucAdTsdT
sense 1251-1270 7591 UGAUCUGGGGGAACUUGAA 7592
UGAUCUGGGGGAACUUGAAdTsdT antis 1252-1271 7593 UCAAGUUCCCCCAGAUCAA
7594 ucAAGuucccccAGAucAAdTsdT sense 1252-1271 7595
UUGAUCUGGGGGAACUUGA 7596 UUGAUCUGGGGGAACUUGAdTsdT antis 1253-1272
7597 CAAGUUCCCCCAGAUCAAA 7598 cAAGuucccccAGAucAAAdTsdT sense
1253-1272 7599 UUUGAUCUGGGGGAACUUG 7600 UUUGAUCUGGGGGAACUUGdTsdT
antis 1255-1274 7601 AGUUCCCCCAGAUCAAAGC 7602
AGuucccccAGAucAAAGcdTsdT sense 1255-1274 7603 GCUUUGAUCUGGGGGAACU
7604 GCUUUGAUCUGGGGGAACUdTsdT antis 1257-1276 7605
UUCCCCCAGAUCAAAGCUC 7606 uucccccAGAucAAAGcucdTsdT sense 1257-1276
7607 GAGCUUUGAUCUGGGGGAA 7608 GAGCUUUGAUCUGGGGGAAdTsdT antis
1258-1277 7609 UCCCCCAGAUCAAAGCUCA 7610 ucccccAGAucAAAGcucAdTsdT
sense 1258-1277 7611 UGAGCUUUGAUCUGGGGGA 7612
UGAGCUUUGAUCUGGGGGAdTsdT antis 1261-1280 7613 CCCAGAUCAAAGCUCACCC
7614 cccAGAucAAAGcucAcccdTsdT sense 1261-1280 7615
GGGUGAGCUUUGAUCUGGG 7616 GGGUGAGCUUUGAUCUGGGdTsdT antis 1262-1281
7617 CCAGAUCAAAGCUCACCCU 7618 ccAGAucAAAGcucAcccudTsdT sense
1262-1281 7619 AGGGUGAGCUUUGAUCUGG 7620 AGGGUGAGCUUUGAUCUGGdTsdT
antis 1280-1299 7621 UUGGACAAAGGUGUUCAAA 7622
uuGGAcAAAGGuGuucAAAdTsdT sense 1280-1299 7623 UUUGAACACCUUUGUCCAA
7624 UUUGAAcACCUUUGUCcAAdTsdT antis 1282-1301 7625
GGACAAAGGUGUUCAAAUC 7626 GGAcAAAGGuGuucAAAucdTsdT sense 1282-1301
7627 GAUUUGAACACCUUUGUCC 7628 GAUUUGAAcACCUUUGUCCdTsdT antis
1283-1302 7629 GACAAAGGUGUUCAAAUCU 7630 GAcAAAGGuGuucAAAucudTsdT
sense 1283-1302 7631 AGAUUUGAACACCUUUGUC 7632
AGAUUUGAAcACCUUUGUCdTsdT antis 1284-1303 7633 ACAAAGGUGUUCAAAUCUU
7634 AcAAAGGuGuucAAAucuudTsdT sense 1284-1303 7635
AAGAUUUGAACACCUUUGU 7636 AAGAUUUGAAcACCUUUGUdTsdT antis 1354-1373
7637 CGCCAUCCUCAAGGCUCUC 7638 cGccAuccucAAGGcucucdTsdT sense
1354-1373 7639 GAGAGCCUUGAGGAUGGCG 7640 GAGAGCCUUGAGGAUGGCGdTsdT
antis 1361-1380 7641 CUCAAGGCUCUCCCCACUC 7642
cucAAGGcucuccccAcucdTsdT sense 1361-1380 7643 GAGUGGGGAGAGCCUUGAG
7644 GAGUGGGGAGAGCCUUGAGdTsdT antis 1379-1398 7645
CGAGGCUUGUGCCCACAGC 7646 cGAGGcuuGuGcccAcAGcdTsdT sense 1379-1398
7647 GCUGUGGGCACAAGCCUCG 7648 GCUGUGGGcAcAAGCCUCGdTsdT antis
1380-1399 7649 GAGGCUUGUGCCCACAGCU 7650 GAGGcuuGuGcccAcAGcudTsdT
sense 1380-1399 7651 AGCUGUGGGCACAAGCCUC 7652
AGCUGUGGGcAcAAGCCUCdTsdT antis 1382-1401 7653 GGCUUGUGCCCACAGCUUC
7654 GGcuuGuGcccAcAGcuucdTsdT sense 1382-1401 7655
GAAGCUGUGGGCACAAGCC 7656 GAAGCUGUGGGcAcAAGCCdTsdT antis 1383-1402
7657 GCUUGUGCCCACAGCUUCU 7658 GcuuGuGcccAcAGcuucudTsdT sense
1383-1402 7659 AGAAGCUGUGGGCACAAGC 7660 AGAAGCUGUGGGcAcAAGCdTsdT
antis 1384-1403 7661 CUUGUGCCCACAGCUUCUU 7662
cuuGuGcccAcAGcuucuudTsdT sense 1384-1403 7663 AAGAAGCUGUGGGCACAAG
7664 AAGAAGCUGUGGGcAcAAGdTsdT antis 1386-1405 7665
UGUGCCCACAGCUUCUUCG 7666 uGuGcccAcAGcuucuucGdTsdT sense 1386-1405
7667 CGAAGAAGCUGUGGGCACA 7668 CGAAGAAGCUGUGGGcAcAdTsdT antis
1424-1443 7669 AGCCCAGCUCCCCAACGAC 7670 AGcccAGcuccccAAcGAcdTsdT
sense 1424-1443 7671 GUCGUUGGGGAGCUGGGCU 7672
GUCGUUGGGGAGCUGGGCUdTsdT antis 1425-1444 7673 GCCCAGCUCCCCAACGACC
7674 GcccAGcuccccAAcGAccdTsdT sense 1425-1444 7675
GGUCGUUGGGGAGCUGGGC 7676 GGUCGUUGGGGAGCUGGGCdTsdT antis 1426-1445
7677 CCCAGCUCCCCAACGACCG 7678 cccAGcuccccAAcGAccGdTsdT sense
1426-1445 7679 CGGUCGUUGGGGAGCUGGG 7680 CGGUCGUUGGGGAGCUGGGdTsdT
antis 1427-1446 7681 CCAGCUCCCCAACGACCGC 7682
ccAGcuccccAAcGAccGcdTsdT sense 1427-1446 7683 GCGGUCGUUGGGGAGCUGG
7684 GCGGUCGUUGGGGAGCUGGdTsdT antis 1428-1447 7685
CAGCUCCCCAACGACCGCC 7686 cAGcuccccAAcGAccGccdTsdT sense 1428-1447
7687 GGCGGUCGUUGGGGAGCUG 7688 GGCGGUCGUUGGGGAGCUGdTsdT antis
1454-1473 7689 CCCCCUGUUCAACUUCAGU 7690 cccccuGuucAAcuucAGudTsdT
sense 1454-1473 7691 ACUGAAGUUGAACAGGGGG 7692
ACUGAAGUUGAAcAGGGGGdTsdT antis 1459-1478 7693 UGUUCAACUUCAGUCCUGG
7694 uGuucAAcuucAGuccuGGdTsdT sense 1459-1478 7695
CCAGGACUGAAGUUGAACA 7696 CcAGGACUGAAGUUGAAcAdTsdT antis 1460-1479
7697 GUUCAACUUCAGUCCUGGU 7698 GuucAAcuucAGuccuGGudTsdT sense
1460-1479 7699 ACCAGGACUGAAGUUGAAC 7700 ACcAGGACUGAAGUUGAACdTsdT
antis 1461-1480 7701 UUCAACUUCAGUCCUGGUG 7702
uucAAcuucAGuccuGGuGdTsdT sense 1461-1480 7703 CACCAGGACUGAAGUUGAA
7704 cACcAGGACUGAAGUUGAAdTsdT antis 1462-1481 7705
UCAACUUCAGUCCUGGUGA 7706 ucAAcuucAGuccuGGuGAdTsdT sense 1462-1481
7707 UCACCAGGACUGAAGUUGA 7708 UcACcAGGACUGAAGUUGAdTsdT antis
1463-1482 7709 CAACUUCAGUCCUGGUGAA 7710 cAAcuucAGuccuGGuGAAdTsdT
sense 1463-1482 7711 UUCACCAGGACUGAAGUUG 7712
UUcACcAGGACUGAAGUUGdTsdT antis 1503-1522 7713 AAUGCCAUUCUCAUCCCUC
7714 AAuGccAuucucAucccucdTsdT sense 1503-1522 7715
GAGGGAUGAGAAUGGCAUU 7716 GAGGGAUGAGAAUGGcAUUdTsdT antis 1504-1523
7717 AUGCCAUUCUCAUCCCUCC 7718 AuGccAuucucAucccuccdTsdT sense
1504-1523 7719 GGAGGGAUGAGAAUGGCAU 7720 GGAGGGAUGAGAAUGGcAUdTsdT
antis 1505-1524 7721 UGCCAUUCUCAUCCCUCCU 7722
uGccAuucucAucccuccudTsdT sense 1505-1524 7723 AGGAGGGAUGAGAAUGGCA
7724 AGGAGGGAUGAGAAUGGcAdTsdT antis 1506-1525 7725
GCCAUUCUCAUCCCUCCUC 7726 GccAuucucAucccuccucdTsdT sense 1506-1525
7727 GAGGAGGGAUGAGAAUGGC 7728 GAGGAGGGAUGAGAAUGGCdTsdT antis
1507-1526 7729 CCAUUCUCAUCCCUCCUCA 7730 ccAuucucAucccuccucAdTsdT
sense 1507-1526 7731 UGAGGAGGGAUGAGAAUGG 7732
UGAGGAGGGAUGAGAAUGGdTsdT antis 1508-1527 7733 CAUUCUCAUCCCUCCUCAC
7734 cAuucucAucccuccucAcdTsdT sense 1508-1527 7735
GUGAGGAGGGAUGAGAAUG 7736 GUGAGGAGGGAUGAGAAUGdTsdT antis 1509-1528
7737 AUUCUCAUCCCUCCUCACU 7738 AuucucAucccuccucAcudTsdT sense
1509-1528 7739 AGUGAGGAGGGAUGAGAAU 7740 AGUGAGGAGGGAUGAGAAUdTsdT
antis 1510-1529 7741 UUCUCAUCCCUCCUCACUU 7742
uucucAucccuccucAcuudTsdT sense 1510-1529 7743 AAGUGAGGAGGGAUGAGAA
7744 AAGUGAGGAGGGAUGAGAAdTsdT antis 1511-1530 7745
UCUCAUCCCUCCUCACUUG 7746 ucucAucccuccucAcuuGdTsdT sense 1511-1530
7747 CAAGUGAGGAGGGAUGAGA 7748 cAAGUGAGGAGGGAUGAGAdTsdT antis
1515-1534 7749 AUCCCUCCUCACUUGAGGU 7750 AucccuccucAcuuGAGGudTsdT
sense 1515-1534 7751 ACCUCAAGUGAGGAGGGAU 7752
ACCUcAAGUGAGGAGGGAUdTsdT antis 1516-1535 7753 UCCCUCCUCACUUGAGGUC
7754 ucccuccucAcuuGAGGucdTsdT sense 1516-1535 7755
GACCUCAAGUGAGGAGGGA 7756 GACCUcAAGUGAGGAGGGAdTsdT antis 1520-1539
7757 UCCUCACUUGAGGUCCCCA 7758 uccucAcuuGAGGuccccAdTsdT sense
1520-1539 7759 UGGGGACCUCAAGUGAGGA 7760 UGGGGACCUcAAGUGAGGAdTsdT
antis 1522-1541 7761 CUCACUUGAGGUCCCCAGC 7762
cucAcuuGAGGuccccAGcdTsdT sense 1522-1541 7763 GCUGGGGACCUCAAGUGAG
7764 GCUGGGGACCUcAAGUGAGdTsdT antis 1523-1542 7765
UCACUUGAGGUCCCCAGCA 7766 ucAcuuGAGGuccccAGcAdTsdT sense 1523-1542
7767 UGCUGGGGACCUCAAGUGA 7768 UGCUGGGGACCUcAAGUGAdTsdT antis
1524-1543 7769 CACUUGAGGUCCCCAGCAG 7770 cAcuuGAGGuccccAGcAGdTsdT
sense 1524-1543 7771 CUGCUGGGGACCUCAAGUG 7772
CUGCUGGGGACCUcAAGUGdTsdT antis 1528-1547 7773 UGAGGUCCCCAGCAGGCCC
7774 uGAGGuccccAGcAGGcccdTsdT sense 1528-1547 7775
GGGCCUGCUGGGGACCUCA 7776 GGGCCUGCUGGGGACCUcAdTsdT antis 1529-1548
7777 GAGGUCCCCAGCAGGCCCU 7778 GAGGuccccAGcAGGcccudTsdT sense
1529-1548 7779 AGGGCCUGCUGGGGACCUC 7780 AGGGCCUGCUGGGGACCUCdTsdT
antis 1539-1558 7781 GCAGGCCCUGCUUCUCCCC 7782
GcAGGcccuGcuucuccccdTsdT sense 1539-1558 7783 GGGGAGAAGCAGGGCCUGC
7784 GGGGAGAAGcAGGGCCUGCdTsdT antis 1577-1596 7785
AUCCUCACAAGCUUUAACU 7786 AuccucAcAAGcuuuAAcudTsdT sense 1577-1596
7787 AGUUAAAGCUUGUGAGGAU 7788 AGUuAAAGCUUGUGAGGAUdTsdT antis
1578-1597 7789 UCCUCACAAGCUUUAACUG 7790 uccucAcAAGcuuuAAcuGdTsdT
sense 1578-1597 7791 CAGUUAAAGCUUGUGAGGA 7792
cAGUuAAAGCUUGUGAGGAdTsdT antis 1579-1598 7793 CCUCACAAGCUUUAACUGA
7794 ccucAcAAGcuuuAAcuGAdTsdT sense 1579-1598 7795
UCAGUUAAAGCUUGUGAGG 7796 UcAGUuAAAGCUUGUGAGGdTsdT antis 1582-1601
7797 CACAAGCUUUAACUGAAGC 7798 cAcAAGcuuuAAcuGAAGcdTsdT sense
1582-1601 7799 GCUUCAGUUAAAGCUUGUG 7800 GCUUcAGUuAAAGCUUGUGdTsdT
antis 1587-1606 7801 GCUUUAACUGAAGCUCAGA 7802
GcuuuAAcuGAAGcucAGAdTsdT sense 1587-1606 7803 UCUGAGCUUCAGUUAAAGC
7804 UCUGAGCUUcAGUuAAAGCdTsdT antis 1623-1642 7805
CCAUCUGAUGCCACAACUG 7806 ccAucuGAuGccAcAAcuGdTsdT sense 1623-1642
7807 CAGUUGUGGCAUCAGAUGG 7808 cAGUUGUGGcAUcAGAUGGdTsdT antis
1624-1643 7809 CAUCUGAUGCCACAACUGC 7810 cAucuGAuGccAcAAcuGcdTsdT
sense 1624-1643 7811 GCAGUUGUGGCAUCAGAUG 7812
GcAGUUGUGGcAUcAGAUGdTsdT antis 1625-1644 7813 AUCUGAUGCCACAACUGCU
7814 AucuGAuGccAcAAcuGcudTsdT sense 1625-1644 7815
AGCAGUUGUGGCAUCAGAU 7816 AGcAGUUGUGGcAUcAGAUdTsdT antis 1630-1649
7817 AUGCCACAACUGCUACCCU 7818 AuGccAcAAcuGcuAcccudTsdT sense
1630-1649 7819 AGGGUAGCAGUUGUGGCAU 7820 AGGGuAGcAGUUGUGGcAUdTsdT
antis 1631-1650 7821 UGCCACAACUGCUACCCUC 7822
uGccAcAAcuGcuAcccucdTsdT sense 1631-1650 7823 GAGGGUAGCAGUUGUGGCA
7824 GAGGGuAGcAGUUGUGGcAdTsdT antis 1632-1651 7825
GCCACAACUGCUACCCUCG 7826 GccAcAAcuGcuAcccucGdTsdT sense 1632-1651
7827 CGAGGGUAGCAGUUGUGGC 7828 CGAGGGuAGcAGUUGUGGCdTsdT antis
1633-1652 7829 CCACAACUGCUACCCUCGC 7830 ccAcAAcuGcuAcccucGcdTsdT
sense 1633-1652 7831 GCGAGGGUAGCAGUUGUGG 7832
GCGAGGGuAGcAGUUGUGGdTsdT antis 1668-1687 7833 CCCCACCGACUACCCCUCC
7834 ccccAccGAcuAccccuccdTsdT sense 1668-1687 7835
GGAGGGGUAGUCGGUGGGG 7836 GGAGGGGuAGUCGGUGGGGdTsdT antis 1678-1697
7837 UACCCCUCCACGUCCAUCU 7838 uAccccuccAcGuccAucudTsdT sense
1678-1697 7839 AGAUGGACGUGGAGGGGUA 7840 AGAUGGACGUGGAGGGGuAdTsdT
antis 1681-1700 7841 CCCUCCACGUCCAUCUGGG 7842
cccuccAcGuccAucuGGGdTsdT sense 1681-1700 7843 CCCAGAUGGACGUGGAGGG
7844 CCcAGAUGGACGUGGAGGGdTsdT antis 1683-1702 7845
CUCCACGUCCAUCUGGGAA 7846 cuccAcGuccAucuGGGAAdTsdT sense 1683-1702
7847 UUCCCAGAUGGACGUGGAG 7848 UUCCcAGAUGGACGUGGAGdTsdT antis
1690-1709 7849 UCCAUCUGGGAAGGCCCAA 7850 uccAucuGGGAAGGcccAAdTsdT
sense 1690-1709 7851 UUGGGCCUUCCCAGAUGGA 7852
UUGGGCCUUCCcAGAUGGAdTsdT antis 1691-1710 7853 CCAUCUGGGAAGGCCCAAG
7854 ccAucuGGGAAGGcccAAGdTsdT sense 1691-1710 7855
CUUGGGCCUUCCCAGAUGG 7856 CUUGGGCCUUCCcAGAUGGdTsdT antis 1692-1711
7857 CAUCUGGGAAGGCCCAAGU 7858 cAucuGGGAAGGcccAAGudTsdT sense
1692-1711 7859 ACUUGGGCCUUCCCAGAUG 7860 ACUUGGGCCUUCCcAGAUGdTsdT
antis 1693-1712 7861 AUCUGGGAAGGCCCAAGUG 7862
AucuGGGAAGGcccAAGuGdTsdT sense 1693-1712 7863 CACUUGGGCCUUCCCAGAU
7864 cACUUGGGCCUUCCcAGAUdTsdT antis 1696-1715 7865
UGGGAAGGCCCAAGUGGCG 7866 uGGGAAGGcccAAGuGGcGdTsdT sense 1696-1715
7867 CGCCACUUGGGCCUUCCCA 7868 CGCcACUUGGGCCUUCCcAdTsdT antis
1697-1716 7869 GGGAAGGCCCAAGUGGCGC 7870 GGGAAGGcccAAGuGGcGcdTsdT
sense 1697-1716 7871 GCGCCACUUGGGCCUUCCC 7872
GCGCcACUUGGGCCUUCCCdTsdT antis 1698-1717 7873 GGAAGGCCCAAGUGGCGCU
7874 GGAAGGcccAAGuGGcGcudTsdT sense 1698-1717 7875
AGCGCCACUUGGGCCUUCC 7876 AGCGCcACUUGGGCCUUCCdTsdT antis 1699-1718
7877 GAAGGCCCAAGUGGCGCUG 7878 GAAGGcccAAGuGGcGcuGdTsdT sense
1699-1718 7879 CAGCGCCACUUGGGCCUUC 7880 cAGCGCcACUUGGGCCUUCdTsdT
antis 1700-1719 7881 AAGGCCCAAGUGGCGCUGG 7882
AAGGcccAAGuGGcGcuGGdTsdT sense 1700-1719 7883 CCAGCGCCACUUGGGCCUU
7884 CcAGCGCcACUUGGGCCUUdTsdT antis 1701-1720 7885
AGGCCCAAGUGGCGCUGGG 7886 AGGcccAAGuGGcGcuGGGdTsdT sense 1701-1720
7887 CCCAGCGCCACUUGGGCCU 7888 CCcAGCGCcACUUGGGCCUdTsdT antis
1702-1721 7889 GGCCCAAGUGGCGCUGGGA 7890 GGcccAAGuGGcGcuGGGAdTsdT
sense 1702-1721 7891 UCCCAGCGCCACUUGGGCC 7892
UCCcAGCGCcACUUGGGCCdTsdT antis 1707-1726 7893 AAGUGGCGCUGGGAAGGGG
7894 AAGuGGcGcuGGGAAGGGGdTsdT sense 1707-1726 7895
CCCCUUCCCAGCGCCACUU 7896 CCCCUUCCcAGCGCcACUUdTsdT antis 1708-1727
7897 AGUGGCGCUGGGAAGGGGG 7898 AGuGGcGcuGGGAAGGGGGdTsdT sense
1708-1727 7899 CCCCCUUCCCAGCGCCACU 7900 CCCCCUUCCcAGCGCcACUdTsdT
antis 1712-1731 7901 GCGCUGGGAAGGGGGCCAC 7902
GcGcuGGGAAGGGGGccAcdTsdT sense 1712-1731 7903 GUGGCCCCCUUCCCAGCGC
7904 GUGGCCCCCUUCCcAGCGCdTsdT antis 1713-1732 7905
CGCUGGGAAGGGGGCCACA 7906 cGcuGGGAAGGGGGccAcAdTsdT sense 1713-1732
7907 UGUGGCCCCCUUCCCAGCG 7908 UGUGGCCCCCUUCCcAGCGdTsdT antis
1715-1734 7909 CUGGGAAGGGGGCCACAGC 7910 cuGGGAAGGGGGccAcAGcdTsdT
sense 1715-1734 7911 GCUGUGGCCCCCUUCCCAG 7912
GCUGUGGCCCCCUUCCcAGdTsdT antis 1716-1735 7913 UGGGAAGGGGGCCACAGCC
7914 uGGGAAGGGGGccAcAGccdTsdT sense 1716-1735 7915
GGCUGUGGCCCCCUUCCCA 7916 GGCUGUGGCCCCCUUCCcAdTsdT antis 1717-1736
7917 GGGAAGGGGGCCACAGCCC 7918 GGGAAGGGGGccAcAGcccdTsdT sense
1717-1736 7919 GGGCUGUGGCCCCCUUCCC 7920 GGGCUGUGGCCCCCUUCCCdTsdT
antis 1718-1737 7921 GGAAGGGGGCCACAGCCCA 7922
GGAAGGGGGccAcAGcccAdTsdT sense 1718-1737 7923 UGGGCUGUGGCCCCCUUCC
7924 UGGGCUGUGGCCCCCUUCCdTsdT antis 1719-1738 7925
GAAGGGGGCCACAGCCCAU 7926 GAAGGGGGccAcAGcccAudTsdT sense 1719-1738
7927 AUGGGCUGUGGCCCCCUUC 7928 AUGGGCUGUGGCCCCCUUCdTsdT antis
1720-1739 7929 AAGGGGGCCACAGCCCAUC 7930 AAGGGGGccAcAGcccAucdTsdT
sense 1720-1739 7931 GAUGGGCUGUGGCCCCCUU 7932
GAUGGGCUGUGGCCCCCUUdTsdT antis 1721-1740 7933 AGGGGGCCACAGCCCAUCA
7934 AGGGGGccAcAGcccAucAdTsdT sense 1721-1740 7935
UGAUGGGCUGUGGCCCCCU 7936 UGAUGGGCUGUGGCCCCCUdTsdT antis 1724-1743
7937 GGGCCACAGCCCAUCAAGC 7938 GGGccAcAGcccAucAAGcdTsdT sense
1724-1743 7939 GCUUGAUGGGCUGUGGCCC 7940 GCUUGAUGGGCUGUGGCCCdTsdT
antis 1725-1744 7941 GGCCACAGCCCAUCAAGCU 7942
GGccAcAGcccAucAAGcudTsdT sense 1725-1744 7943 AGCUUGAUGGGCUGUGGCC
7944 AGCUUGAUGGGCUGUGGCCdTsdT antis 1727-1746 7945
CCACAGCCCAUCAAGCUCC 7946 ccAcAGcccAucAAGcuccdTsdT sense 1727-1746
7947 GGAGCUUGAUGGGCUGUGG 7948 GGAGCUUGAUGGGCUGUGGdTsdT antis
1728-1747 7949 CACAGCCCAUCAAGCUCCU 7950 cAcAGcccAucAAGcuccudTsdT
sense 1728-1747 7951 AGGAGCUUGAUGGGCUGUG 7952
AGGAGCUUGAUGGGCUGUGdTsdT antis 1729-1748 7953 ACAGCCCAUCAAGCUCCUG
7954 AcAGcccAucAAGcuccuGdTsdT sense 1729-1748 7955
CAGGAGCUUGAUGGGCUGU 7956 cAGGAGCUUGAUGGGCUGUdTsdT antis 1733-1752
7957 CCCAUCAAGCUCCUGCCCU 7958 cccAucAAGcuccuGcccudTsdT sense
1733-1752 7959 AGGGCAGGAGCUUGAUGGG 7960 AGGGcAGGAGCUUGAUGGGdTsdT
antis 1734-1753 7961 CCAUCAAGCUCCUGCCCUG 7962
ccAucAAGcuccuGcccuGdTsdT sense 1734-1753 7963 CAGGGCAGGAGCUUGAUGG
7964 cAGGGcAGGAGCUUGAUGGdTsdT antis 1735-1754 7965
CAUCAAGCUCCUGCCCUGG 7966 cAucAAGcuccuGcccuGGdTsdT sense 1735-1754
7967 CCAGGGCAGGAGCUUGAUG 7968 CcAGGGcAGGAGCUUGAUGdTsdT antis
1736-1755 7969 AUCAAGCUCCUGCCCUGGC 7970 AucAAGcuccuGcccuGGcdTsdT
sense 1736-1755 7971 GCCAGGGCAGGAGCUUGAU 7972
GCcAGGGcAGGAGCUUGAUdTsdT antis 1738-1757 7973 CAAGCUCCUGCCCUGGCUG
7974 cAAGcuccuGcccuGGcuGdTsdT sense 1738-1757 7975
CAGCCAGGGCAGGAGCUUG 7976 cAGCcAGGGcAGGAGCUUGdTsdT antis 1739-1758
7977 AAGCUCCUGCCCUGGCUGG 7978 AAGcuccuGcccuGGcuGGdTsdT sense
1739-1758 7979 CCAGCCAGGGCAGGAGCUU 7980 CcAGCcAGGGcAGGAGCUUdTsdT
antis 1742-1761 7981 CUCCUGCCCUGGCUGGGCC 7982
cuccuGcccuGGcuGGGccdTsdT sense 1742-1761 7983 GGCCCAGCCAGGGCAGGAG
7984 GGCCcAGCcAGGGcAGGAGdTsdT antis 1745-1764 7985
CUGCCCUGGCUGGGCCCCU 7986 cuGcccuGGcuGGGccccudTsdT sense 1745-1764
7987 AGGGGCCCAGCCAGGGCAG 7988 AGGGGCCcAGCcAGGGcAGdTsdT antis
1747-1766 7989 GCCCUGGCUGGGCCCCUAG 7990 GcccuGGcuGGGccccuAGdTsdT
sense 1747-1766 7991 CUAGGGGCCCAGCCAGGGC 7992
CuAGGGGCCcAGCcAGGGCdTsdT antis 1749-1768 7993 CCUGGCUGGGCCCCUAGAC
7994 ccuGGcuGGGccccuAGAcdTsdT sense 1749-1768 7995
GUCUAGGGGCCCAGCCAGG 7996 GUCuAGGGGCCcAGCcAGGdTsdT antis 1750-1769
7997 CUGGCUGGGCCCCUAGACU 7998 cuGGcuGGGccccuAGAcudTsdT sense
1750-1769 7999 AGUCUAGGGGCCCAGCCAG 8000 AGUCuAGGGGCCcAGCcAGdTsdT
antis 1751-1770 8001 UGGCUGGGCCCCUAGACUA 8002
uGGcuGGGccccuAGAcuAdTsdT sense 1751-1770 8003 UAGUCUAGGGGCCCAGCCA
8004 uAGUCuAGGGGCCcAGCcAdTsdT antis 1754-1773 8005
CUGGGCCCCUAGACUAGAG 8006 cuGGGccccuAGAcuAGAGdTsdT sense 1754-1773
8007 CUCUAGUCUAGGGGCCCAG 8008 CUCuAGUCuAGGGGCCcAGdTsdT antis
1756-1775 8009 GGGCCCCUAGACUAGAGGG 8010 GGGccccuAGAcuAGAGGGdTsdT
sense 1756-1775 8011 CCCUCUAGUCUAGGGGCCC 8012
CCCUCuAGUCuAGGGGCCCdTsdT antis 1757-1776 8013 GGCCCCUAGACUAGAGGGC
8014 GGccccuAGAcuAGAGGGcdTsdT sense 1757-1776 8015
GCCCUCUAGUCUAGGGGCC 8016 GCCCUCuAGUCuAGGGGCCdTsdT antis 1762-1781
8017 CUAGACUAGAGGGCAGAGG 8018 cuAGAcuAGAGGGcAGAGGdTsdT sense
1762-1781 8019 CCUCUGCCCUCUAGUCUAG 8020 CCUCUGCCCUCuAGUCuAGdTsdT
antis
1766-1785 8021 ACUAGAGGGCAGAGGUAAA 8022 AcuAGAGGGcAGAGGuAAAdTsdT
sense 1766-1785 8023 UUUACCUCUGCCCUCUAGU 8024
UUuACCUCUGCCCUCuAGUdTsdT antis 1768-1787 8025 UAGAGGGCAGAGGUAAAUG
8026 uAGAGGGcAGAGGuAAAuGdTsdT sense 1768-1787 8027
CAUUUACCUCUGCCCUCUA 8028 cAUUuACCUCUGCCCUCuAdTsdT antis 1771-1790
8029 AGGGCAGAGGUAAAUGAAC 8030 AGGGcAGAGGuAAAuGAAcdTsdT sense
1771-1790 8031 GUUCAUUUACCUCUGCCCU 8032 GUUcAUUuACCUCUGCCCUdTsdT
antis 1776-1795 8033 AGAGGUAAAUGAACUACCC 8034
AGAGGuAAAuGAAcuAcccdTsdT sense 1776-1795 8035 GGGUAGUUCAUUUACCUCU
8036 GGGuAGUUcAUUuACCUCUdTsdT antis 1783-1802 8037
AAUGAACUACCCCCAGCAU 8038 AAuGAAcuAcccccAGcAudTsdT sense 1783-1802
8039 AUGCUGGGGGUAGUUCAUU 8040 AUGCUGGGGGuAGUUcAUUdTsdT antis
1788-1807 8041 ACUACCCCCAGCAUCUAGG 8042 AcuAcccccAGcAucuAGGdTsdT
sense 1788-1807 8043 CCUAGAUGCUGGGGGUAGU 8044
CCuAGAUGCUGGGGGuAGUdTsdT antis 1789-1808 8045 CUACCCCCAGCAUCUAGGC
8046 cuAcccccAGcAucuAGGcdTsdT sense 1789-1808 8047
GCCUAGAUGCUGGGGGUAG 8048 GCCuAGAUGCUGGGGGuAGdTsdT antis 1791-1810
8049 ACCCCCAGCAUCUAGGCCU 8050 AcccccAGcAucuAGGccudTsdT sense
1791-1810 8051 AGGCCUAGAUGCUGGGGGU 8052 AGGCCuAGAUGCUGGGGGUdTsdT
antis 1793-1812 8053 CCCCAGCAUCUAGGCCUCC 8054
ccccAGcAucuAGGccuccdTsdT sense 1793-1812 8055 GGAGGCCUAGAUGCUGGGG
8056 GGAGGCCuAGAUGCUGGGGdTsdT antis 1797-1816 8057
AGCAUCUAGGCCUCCCUCA 8058 AGcAucuAGGccucccucAdTsdT sense 1797-1816
8059 UGAGGGAGGCCUAGAUGCU 8060 UGAGGGAGGCCuAGAUGCUdTsdT antis
1822-1841 8061 UAACCUCUGUGGUGGGCUU 8062 uAAccucuGuGGuGGGcuudTsdT
sense 1822-1841 8063 AAGCCCACCACAGAGGUUA 8064
AAGCCcACcAcAGAGGUuAdTsdT antis 1823-1842 8065 AACCUCUGUGGUGGGCUUU
8066 AAccucuGuGGuGGGcuuudTsdT sense 1823-1842 8067
AAAGCCCACCACAGAGGUU 8068 AAAGCCcACcAcAGAGGUUdTsdT antis 1826-1845
8069 CUCUGUGGUGGGCUUUUUA 8070 cucuGuGGuGGGcuuuuuAdTsdT sense
1826-1845 8071 UAAAAAGCCCACCACAGAG 8072 uAAAAAGCCcACcAcAGAGdTsdT
antis 1827-1846 8073 UCUGUGGUGGGCUUUUUAA 8074
ucuGuGGuGGGcuuuuuAAdTsdT sense 1827-1846 8075 UUAAAAAGCCCACCACAGA
8076 UuAAAAAGCCcACcAcAGAdTsdT antis 1828-1847 8077
CUGUGGUGGGCUUUUUAAA 8078 cuGuGGuGGGcuuuuuAAAdTsdT sense 1828-1847
8079 UUUAAAAAGCCCACCACAG 8080 UUuAAAAAGCCcACcAcAGdTsdT antis
1829-1848 8081 UGUGGUGGGCUUUUUAAAG 8082 uGuGGuGGGcuuuuuAAAGdTsdT
sense 1829-1848 8083 CUUUAAAAAGCCCACCACA 8084
CUUuAAAAAGCCcACcAcAdTsdT antis 1830-1849 8085 GUGGUGGGCUUUUUAAAGA
8086 GuGGuGGGcuuuuuAAAGAdTsdT sense 1830-1849 8087
UCUUUAAAAAGCCCACCAC 8088 UCUUuAAAAAGCCcACcACdTsdT antis 1832-1851
8089 GGUGGGCUUUUUAAAGAGG 8090 GGuGGGcuuuuuAAAGAGGdTsdT sense
1832-1851 8091 CCUCUUUAAAAAGCCCACC 8092 CCUCUUuAAAAAGCCcACCdTsdT
antis 1835-1854 8093 GGGCUUUUUAAAGAGGAUU 8094
GGGcuuuuuAAAGAGGAuudTsdT sense 1835-1854 8095 AAUCCUCUUUAAAAAGCCC
8096 AAUCCUCUUuAAAAAGCCCdTsdT antis 1836-1855 8097
GGCUUUUUAAAGAGGAUUU 8098 GGcuuuuuAAAGAGGAuuudTsdT sense 1836-1855
8099 AAAUCCUCUUUAAAAAGCC 8100 AAAUCCUCUUuAAAAAGCCdTsdT antis
1884-1903 8101 AAGGACGGGGUUUGGGGGU 8102 AAGGAcGGGGuuuGGGGGudTsdT
sense 1884-1903 8103 ACCCCCAAACCCCGUCCUU 8104
ACCCCcAAACCCCGUCCUUdTsdT antis 1886-1905 8105 GGACGGGGUUUGGGGGUGU
8106 GGAcGGGGuuuGGGGGuGudTsdT sense 1886-1905 8107
ACACCCCCAAACCCCGUCC 8108 AcACCCCcAAACCCCGUCCdTsdT antis 1889-1908
8109 CGGGGUUUGGGGGUGUGAG 8110 cGGGGuuuGGGGGuGuGAGdTsdT sense
1889-1908 8111 CUCACACCCCCAAACCCCG 8112 CUcAcACCCCcAAACCCCGdTsdT
antis 1890-1909 8113 GGGGUUUGGGGGUGUGAGG 8114
GGGGuuuGGGGGuGuGAGGdTsdT sense 1890-1909 8115 CCUCACACCCCCAAACCCC
8116 CCUcAcACCCCcAAACCCCdTsdT antis 1891-1910 8117
GGGUUUGGGGGUGUGAGGA 8118 GGGuuuGGGGGuGuGAGGAdTsdT sense 1891-1910
8119 UCCUCACACCCCCAAACCC 8120 UCCUcAcACCCCcAAACCCdTsdT antis
1892-1911 8121 GGUUUGGGGGUGUGAGGAC 8122 GGuuuGGGGGuGuGAGGAcdTsdT
sense 1892-1911 8123 GUCCUCACACCCCCAAACC 8124
GUCCUcAcACCCCcAAACCdTsdT antis 1893-1912 8125 GUUUGGGGGUGUGAGGACC
8126 GuuuGGGGGuGuGAGGAccdTsdT sense 1893-1912 8127
GGUCCUCACACCCCCAAAC 8128 GGUCCUcAcACCCCcAAACdTsdT antis 1894-1913
8129 UUUGGGGGUGUGAGGACCU 8130 uuuGGGGGuGuGAGGAccudTsdT sense
1894-1913 8131 AGGUCCUCACACCCCCAAA 8132 AGGUCCUcAcACCCCcAAAdTsdT
antis 1895-1914 8133 UUGGGGGUGUGAGGACCUU 8134
uuGGGGGuGuGAGGAccuudTsdT sense 1895-1914 8135 AAGGUCCUCACACCCCCAA
8136 AAGGUCCUcAcACCCCcAAdTsdT antis 1914-1933 8137
CUACCCCCUUGGUCCCCUC 8138 cuAcccccuuGGuccccucdTsdT sense 1914-1933
8139 GAGGGGACCAAGGGGGUAG 8140 GAGGGGACcAAGGGGGuAGdTsdT antis
1915-1934 8141 UACCCCCUUGGUCCCCUCC 8142 uAcccccuuGGuccccuccdTsdT
sense 1915-1934 8143 GGAGGGGACCAAGGGGGUA 8144
GGAGGGGACcAAGGGGGuAdTsdT antis 1916-1935 8145 ACCCCCUUGGUCCCCUCCC
8146 AcccccuuGGuccccucccdTsdT sense 1916-1935 8147
GGGAGGGGACCAAGGGGGU 8148 GGGAGGGGACcAAGGGGGUdTsdT antis 1917-1936
8149 CCCCCUUGGUCCCCUCCCC 8150 cccccuuGGuccccuccccdTsdT sense
1917-1936 8151 GGGGAGGGGACCAAGGGGG 8152 GGGGAGGGGACcAAGGGGGdTsdT
antis 1918-1937 8153 CCCCUUGGUCCCCUCCCCU 8154
ccccuuGGuccccuccccudTsdT sense 1918-1937 8155 AGGGGAGGGGACCAAGGGG
8156 AGGGGAGGGGACcAAGGGGdTsdT antis 1919-1938 8157
CCCUUGGUCCCCUCCCCUC 8158 cccuuGGuccccuccccucdTsdT sense 1919-1938
8159 GAGGGGAGGGGACCAAGGG 8160 GAGGGGAGGGGACcAAGGGdTsdT antis
1920-1939 8161 CCUUGGUCCCCUCCCCUCC 8162 ccuuGGuccccuccccuccdTsdT
sense 1920-1939 8163 GGAGGGGAGGGGACCAAGG 8164
GGAGGGGAGGGGACcAAGGdTsdT antis 1921-1940 8165 CUUGGUCCCCUCCCCUCCC
8166 cuuGGuccccuccccucccdTsdT sense 1921-1940 8167
GGGAGGGGAGGGGACCAAG 8168 GGGAGGGGAGGGGACcAAGdTsdT antis 1922-1941
8169 UUGGUCCCCUCCCCUCCCC 8170 uuGGuccccuccccuccccdTsdT sense
1922-1941 8171 GGGGAGGGGAGGGGACCAA 8172 GGGGAGGGGAGGGGACcAAdTsdT
antis 2116-2135 8173 UUCUUGUCCUCUGCUCCCA 8174
uucuuGuccucuGcucccAdTsdT sense 2116-2135 8175 UGGGAGCAGAGGACAAGAA
8176 UGGGAGcAGAGGAcAAGAAdTsdT antis 213-232 8177
GGAGGCGGCCCUGGGGGCU 8178 GGAGGcGGcccuGGGGGcudTsdT sense 213-232
8179 AGCCCCCAGGGCCGCCUCC 8180 AGCCCCcAGGGCCGCCUCCdTsdT antis
358-377 8181 UGGGUGGGGGCGUGGGAGC 8182 uGGGuGGGGGcGuGGGAGcdTsdT
sense 358-377 8183 GCUCCCACGCCCCCACCCA 8184
GCUCCcACGCCCCcACCcAdTsdT antis 528-547 8185 CGUUCCCAAGAAGUGGCUU
8186 cGuucccAAGAAGuGGcuudTsdT sense 528-547 8187
AAGCCACUUCUUGGGAACG 8188 AAGCcACUUCUUGGGAACGdTsdT antis 559-578
8189 AAGUGAUUGGUAAUGGCUC 8190 AAGuGAuuGGuAAuGGcucdTsdT sense
559-578 8191 GAGCCAUUACCAAUCACUU 8192 GAGCcAUuACcAAUcACUUdTsdT
antis 623-642 8193 GGUGGCCAUCAAGAAGGUU 8194
GGuGGccAucAAGAAGGuudTsdT sense 623-642 8195 AACCUUCUUGAUGGCCACC
8196 AACCUUCUUGAUGGCcACCdTsdT antis 630-649 8197
AUCAAGAAGGUUCUUCAGG 8198 AucAAGAAGGuucuucAGGdTsdT sense 630-649
8199 CCUGAAGAACCUUCUUGAU 8200 CCUGAAGAACCUUCUUGAUdTsdT antis
633-652 8201 AAGAAGGUUCUUCAGGACA 8202 AAGAAGGuucuucAGGAcAdTsdT
sense 633-652 8203 UGUCCUGAAGAACCUUCUU 8204
UGUCCUGAAGAACCUUCUUdTsdT antis 801-820 8205 CGAGUGGCCCGCCACUUCA
8206 cGAGuGGcccGccAcuucAdTsdT sense 801-820 8207
UGAAGUGGCGGGCCACUCG 8208 UGAAGUGGCGGGCcACUCGdTsdT antis 859-878
8209 UGUACAUGUACCAGCUCUU 8210 uGuAcAuGuAccAGcucuudTsdT sense
859-878 8211 AAGAGCUGGUACAUGUACA 8212 AAGAGCUGGuAcAUGuAcAdTsdT
antis 936-955 8213 AAUUUGCUUGUGGACCCUG 8214
AAuuuGcuuGuGGAcccuGdTsdT sense 936-955 8215 CAGGGUCCACAAGCAAAUU
8216 cAGGGUCcAcAAGcAAAUUdTsdT antis 944-963 8217
UGUGGACCCUGACACUGCU 8218 uGuGGAcccuGAcAcuGcudTsdT sense 944-963
8219 AGCAGUGUCAGGGUCCACA 8220 AGcAGUGUcAGGGUCcAcAdTsdT antis
960-979 8221 GCUGUCCUCAAGCUCUGCG 8222 GcuGuccucAAGcucuGcGdTsdT
sense 960-979 8223 CGCAGAGCUUGAGGACAGC 8224
CGcAGAGCUUGAGGAcAGCdTsdT antis 966-985 8225 CUCAAGCUCUGCGAUUUUG
8226 cucAAGcucuGcGAuuuuGdTsdT sense 966-985 8227
CAAAAUCGCAGAGCUUGAG 8228 cAAAAUCGcAGAGCUUGAGdTsdT antis 982-1001
8229 UUGGCAGUGCAAAGCAGCU 8230 uuGGcAGuGcAAAGcAGcudTsdT sense
982-1001 8231 AGCUGCUUUGCACUGCCAA 8232 AGCUGCUUUGcACUGCcAAdTsdT
antis 983-1002 8233 UGGCAGUGCAAAGCAGCUG 8234
uGGcAGuGcAAAGcAGcuGdTsdT sense 983-1002 8235 CAGCUGCUUUGCACUGCCA
8236 cAGCUGCUUUGcACUGCcAdTsdT antis 1170-1189 8237
GACCAGCUUGUGGAGAUCA 8238 GAccAGcuuGuGGAGAucAdTsdT sense 1170-1189
8239 UGAUCUCCACAAGCUGGUC 8240 UGAUCUCcAcAAGCUGGUCdTsdT antis
1210-1229 8241 CCAGGGAACAAAUCCGAGA 8242 ccAGGGAAcAAAuccGAGAdTsdT
sense 1210-1229 8243 UCUCGGAUUUGUUCCCUGG 8244
UCUCGGAUUUGUUCCCUGGdTsdT antis 1521-1540 8245 CCUCACUUGAGGUCCCCAG
8246 ccucAcuuGAGGuccccAGdTsdT sense 1521-1540 8247
CUGGGGACCUCAAGUGAGG 8248 CUGGGGACCUcAAGUGAGGdTsdT antis 1533-1552
8249 UCCCCAGCAGGCCCUGCUU 8250 uccccAGcAGGcccuGcuudTsdT sense
1533-1552 8251 AAGCAGGGCCUGCUGGGGA 8252 AAGcAGGGCCUGCUGGGGAdTsdT
antis 1534-1553 8253 CCCCAGCAGGCCCUGCUUC 8254
ccccAGcAGGcccuGcuucdTsdT sense 1534-1553 8255 GAAGCAGGGCCUGCUGGGG
8256 GAAGcAGGGCCUGCUGGGGdTsdT antis 1679-1698 8257
ACCCCUCCACGUCCAUCUG 8258 AccccuccAcGuccAucuGdTsdT sense 1679-1698
8259 CAGAUGGACGUGGAGGGGU 8260 cAGAUGGACGUGGAGGGGUdTsdT antis
1680-1699 8261 CCCCUCCACGUCCAUCUGG 8262 ccccuccAcGuccAucuGGdTsdT
sense 1680-1699 8263 CCAGAUGGACGUGGAGGGG 8264
CcAGAUGGACGUGGAGGGGdTsdT antis 1684-1703 8265 UCCACGUCCAUCUGGGAAG
8266 uccAcGuccAucuGGGAAGdTsdT sense 1684-1703 8267
CUUCCCAGAUGGACGUGGA 8268 CUUCCcAGAUGGACGUGGAdTsdT antis 1710-1729
8269 UGGCGCUGGGAAGGGGGCC 8270 uGGcGcuGGGAAGGGGGccdTsdT sense
1710-1729 8271 GGCCCCCUUCCCAGCGCCA 8272 GGCCCCCUUCCcAGCGCcAdTsdT
antis 1711-1730 8273 GGCGCUGGGAAGGGGGCCA 8274
GGcGcuGGGAAGGGGGccAdTsdT sense 1711-1730 8275 UGGCCCCCUUCCCAGCGCC
8276 UGGCCCCCUUCCcAGCGCCdTsdT antis 1726-1745 8277
GCCACAGCCCAUCAAGCUC 8278 GccAcAGcccAucAAGcucdTsdT sense 1726-1745
8279 GAGCUUGAUGGGCUGUGGC 8280 GAGCUUGAUGGGCUGUGGCdTsdT antis
1731-1750 8281 AGCCCAUCAAGCUCCUGCC 8282 AGcccAucAAGcuccuGccdTsdT
sense 1731-1750 8283 GGCAGGAGCUUGAUGGGCU 8284
GGcAGGAGCUUGAUGGGCUdTsdT antis 1740-1759 8285 AGCUCCUGCCCUGGCUGGG
8286 AGcuccuGcccuGGcuGGGdTsdT sense 1740-1759 8287
CCCAGCCAGGGCAGGAGCU 8288 CCcAGCcAGGGcAGGAGCUdTsdT antis 1741-1760
8289 GCUCCUGCCCUGGCUGGGC 8290 GcuccuGcccuGGcuGGGcdTsdT sense
1741-1760 8291 GCCCAGCCAGGGCAGGAGC 8292 GCCcAGCcAGGGcAGGAGCdTsdT
antis 1767-1786 8293 CUAGAGGGCAGAGGUAAAU 8294
cuAGAGGGcAGAGGuAAAudTsdT sense 1767-1786 8295 AUUUACCUCUGCCCUCUAG
8296 AUUuACCUCUGCCCUCuAGdTsdT antis 1772-1791 8297
GGGCAGAGGUAAAUGAACU 8298 GGGcAGAGGuAAAuGAAcudTsdT sense 1772-1791
8299 AGUUCAUUUACCUCUGCCC 8300 AGUUcAUUuACCUCUGCCCdTsdT antis
1775-1794 8301 CAGAGGUAAAUGAACUACC 8302 cAGAGGuAAAuGAAcuAccdTsdT
sense 1775-1794 8303 GGUAGUUCAUUUACCUCUG 8304
GGuAGUUcAUUuACCUCUGdTsdT antis 1824-1843 8305 ACCUCUGUGGUGGGCUUUU
8306 AccucuGuGGuGGGcuuuudTsdT sense 1824-1843 8307
AAAAGCCCACCACAGAGGU 8308 AAAAGCCcACcAcAGAGGUdTsdT antis 1834-1853
8309 UGGGCUUUUUAAAGAGGAU 8310 uGGGcuuuuuAAAGAGGAudTsdT sense
1834-1853 8311 AUCCUCUUUAAAAAGCCCA 8312 AUCCUCUUuAAAAAGCCcAdTsdT
antis 2015-2034 8313 UUCCCUUCCCUGGCCCCCU 8314
uucccuucccuGGcccccudTsdT sense 2015-2034 8315 AGGGGGCCAGGGAAGGGAA
8316 AGGGGGCcAGGGAAGGGAAdTsdT antis 69-88 8317 GGAGCCGGAGCCCGAACGG
8318 GGAGccGGAGcccGAAcGGdTsdT sense 69-88 8319 CCGUUCGGGCUCCGGCUCC
8320 CCGUUCGGGCUCCGGCUCCdTsdT antis 112-131 8321
CAGGGGAGGCGGCGGCAGA 8322 cAGGGGAGGcGGcGGcAGAdTsdT sense 112-131
8323 UCUGCCGCCGCCUCCCCUG 8324 UCUGCCGCCGCCUCCCCUGdTsdT antis
113-132 8325 AGGGGAGGCGGCGGCAGAG 8326 AGGGGAGGcGGcGGcAGAGdTsdT
sense 113-132 8327 CUCUGCCGCCGCCUCCCCU 8328
CUCUGCCGCCGCCUCCCCUdTsdT antis 114-133 8329 GGGGAGGCGGCGGCAGAGG
8330 GGGGAGGcGGcGGcAGAGGdTsdT sense 114-133 8331
CCUCUGCCGCCGCCUCCCC 8332 CCUCUGCCGCCGCCUCCCCdTsdT antis 116-135
8333 GGAGGCGGCGGCAGAGGCA 8334 GGAGGcGGcGGcAGAGGcAdTsdT sense
116-135 8335 UGCCUCUGCCGCCGCCUCC 8336 UGCCUCUGCCGCCGCCUCCdTsdT
antis 130-149 8337 AGGCAGCGGCGGGGGCAGC 8338
AGGcAGcGGcGGGGGcAGcdTsdT sense 130-149 8339 GCUGCCCCCGCCGCUGCCU
8340 GCUGCCCCCGCCGCUGCCUdTsdT antis 131-150 8341
GGCAGCGGCGGGGGCAGCC 8342 GGcAGcGGcGGGGGcAGccdTsdT sense 131-150
8343 GGCUGCCCCCGCCGCUGCC 8344 GGCUGCCCCCGCCGCUGCCdTsdT antis
166-185 8345 CGCGGCCUGGGCCUGCGCU 8346 cGcGGccuGGGccuGcGcudTsdT
sense 166-185 8347 AGCGCAGGCCCAGGCCGCG 8348
AGCGcAGGCCcAGGCCGCGdTsdT antis 272-291 8349 CGGAGGCGGAGGUGGUGGC
8350 cGGAGGcGGAGGuGGuGGcdTsdT sense 272-291 8351
GCCACCACCUCCGCCUCCG 8352 GCcACcACCUCCGCCUCCGdTsdT antis 273-292
8353 GGAGGCGGAGGUGGUGGCG 8354 GGAGGcGGAGGuGGuGGcGdTsdT sense
273-292 8355 CGCCACCACCUCCGCCUCC 8356 CGCcACcACCUCCGCCUCCdTsdT
antis 274-293 8357 GAGGCGGAGGUGGUGGCGG 8358
GAGGcGGAGGuGGuGGcGGdTsdT sense 274-293 8359 CCGCCACCACCUCCGCCUC
8360 CCGCcACcACCUCCGCCUCdTsdT antis 276-295 8361
GGCGGAGGUGGUGGCGGCG 8362 GGcGGAGGuGGuGGcGGcGdTsdT sense 276-295
8363 CGCCGCCACCACCUCCGCC 8364 CGCCGCcACcACCUCCGCCdTsdT antis
277-296 8365 GCGGAGGUGGUGGCGGCGG 8366 GcGGAGGuGGuGGcGGcGGdTsdT
sense 277-296 8367 CCGCCGCCACCACCUCCGC 8368
CCGCCGCcACcACCUCCGCdTsdT antis 285-304 8369 GGUGGCGGCGGCCCCGGGG
8370 GGuGGcGGcGGccccGGGGdTsdT sense 285-304 8371
CCCCGGGGCCGCCGCCACC 8372 CCCCGGGGCCGCCGCcACCdTsdT antis 286-305
8373 GUGGCGGCGGCCCCGGGGG 8374 GuGGcGGcGGccccGGGGGdTsdT sense
286-305 8375 CCCCCGGGGCCGCCGCCAC 8376 CCCCCGGGGCCGCCGCcACdTsdT
antis 287-306 8377 UGGCGGCGGCCCCGGGGGC 8378
uGGcGGcGGccccGGGGGcdTsdT sense 287-306 8379 GCCCCCGGGGCCGCCGCCA
8380 GCCCCCGGGGCCGCCGCcAdTsdT antis 288-307 8381
GGCGGCGGCCCCGGGGGCU 8382 GGcGGcGGccccGGGGGcudTsdT sense 288-307
8383 AGCCCCCGGGGCCGCCGCC 8384 AGCCCCCGGGGCCGCCGCCdTsdT antis
309-328 8385 GCCUCUGGCCCAGGAGGCA 8386 GccucuGGcccAGGAGGcAdTsdT
sense 309-328 8387 UGCCUCCUGGGCCAGAGGC 8388
UGCCUCCUGGGCcAGAGGCdTsdT antis 310-329 8389 CCUCUGGCCCAGGAGGCAC
8390 ccucuGGcccAGGAGGcAcdTsdT sense 310-329 8391
GUGCCUCCUGGGCCAGAGG 8392 GUGCCUCCUGGGCcAGAGGdTsdT antis 312-331
8393 UCUGGCCCAGGAGGCACUG 8394 ucuGGcccAGGAGGcAcuGdTsdT sense
312-331 8395 CAGUGCCUCCUGGGCCAGA 8396 cAGUGCCUCCUGGGCcAGAdTsdT
antis 313-332 8397 CUGGCCCAGGAGGCACUGG 8398
cuGGcccAGGAGGcAcuGGdTsdT sense 313-332 8399 CCAGUGCCUCCUGGGCCAG
8400 CcAGUGCCUCCUGGGCcAGdTsdT antis 315-334 8401
GGCCCAGGAGGCACUGGCG 8402 GGcccAGGAGGcAcuGGcGdTsdT sense 315-334
8403 CGCCAGUGCCUCCUGGGCC 8404 CGCcAGUGCCUCCUGGGCCdTsdT antis
356-375 8405 UAUGGGUGGGGGCGUGGGA 8406 uAuGGGuGGGGGcGuGGGAdTsdT
sense 356-375 8407 UCCCACGCCCCCACCCAUA 8408
UCCcACGCCCCcACCcAuAdTsdT antis 359-378 8409 GGGUGGGGGCGUGGGAGCC
8410 GGGuGGGGGcGuGGGAGccdTsdT sense 359-378 8411
GGCUCCCACGCCCCCACCC 8412 GGCUCCcACGCCCCcACCCdTsdT antis 360-379
8413 GGUGGGGGCGUGGGAGCCU 8414 GGuGGGGGcGuGGGAGccudTsdT sense
360-379 8415 AGGCUCCCACGCCCCCACC 8416 AGGCUCCcACGCCCCcACCdTsdT
antis 362-381 8417 UGGGGGCGUGGGAGCCUCG 8418
uGGGGGcGuGGGAGccucGdTsdT sense 362-381 8419 CGAGGCUCCCACGCCCCCA
8420 CGAGGCUCCcACGCCCCcAdTsdT antis 367-386 8421
GCGUGGGAGCCUCGAGCUC 8422 GcGuGGGAGccucGAGcucdTsdT sense 367-386
8423 GAGCUCGAGGCUCCCACGC 8424 GAGCUCGAGGCUCCcACGCdTsdT antis
401-420 8425 CGGCAGCGGCGGAGGAGGC 8426 cGGcAGcGGcGGAGGAGGcdTsdT
sense 401-420 8427 GCCUCCUCCGCCGCUGCCG 8428
GCCUCCUCCGCCGCUGCCGdTsdT antis 402-421 8429 GGCAGCGGCGGAGGAGGCA
8430 GGcAGcGGcGGAGGAGGcAdTsdT sense 402-421 8431
UGCCUCCUCCGCCGCUGCC 8432 UGCCUCCUCCGCCGCUGCCdTsdT antis 409-428
8433 GCGGAGGAGGCAGCGGUGG 8434 GcGGAGGAGGcAGcGGuGGdTsdT sense
409-428 8435 CCACCGCUGCCUCCUCCGC 8436 CcACCGCUGCCUCCUCCGCdTsdT
antis 410-429 8437 CGGAGGAGGCAGCGGUGGC 8438
cGGAGGAGGcAGcGGuGGcdTsdT sense 410-429 8439 GCCACCGCUGCCUCCUCCG
8440 GCcACCGCUGCCUCCUCCGdTsdT antis 415-434 8441
GAGGCAGCGGUGGCCCCGG 8442 GAGGcAGcGGuGGccccGGdTsdT sense 415-434
8443 CCGGGGCCACCGCUGCCUC 8444 CCGGGGCcACCGCUGCCUCdTsdT antis
416-435 8445 AGGCAGCGGUGGCCCCGGC 8446 AGGcAGcGGuGGccccGGcdTsdT
sense 416-435 8447 GCCGGGGCCACCGCUGCCU 8448
GCCGGGGCcACCGCUGCCUdTsdT antis 483-502 8449 GGGAAGGUGACCACAGUGG
8450 GGGAAGGuGAccAcAGuGGdTsdT sense 483-502 8451
CCACUGUGGUCACCUUCCC 8452 CcACUGUGGUcACCUUCCCdTsdT antis 484-503
8453 GGAAGGUGACCACAGUGGU 8454 GGAAGGuGAccAcAGuGGudTsdT sense
484-503 8455 ACCACUGUGGUCACCUUCC 8456 ACcACUGUGGUcACCUUCCdTsdT
antis 486-505 8457 AAGGUGACCACAGUGGUAG 8458
AAGGuGAccAcAGuGGuAGdTsdT sense 486-505 8459 CUACCACUGUGGUCACCUU
8460 CuACcACUGUGGUcACCUUdTsdT antis 529-548 8461
GUUCCCAAGAAGUGGCUUA 8462 GuucccAAGAAGuGGcuuAdTsdT sense 529-548
8463 UAAGCCACUUCUUGGGAAC 8464 uAAGCcACUUCUUGGGAACdTsdT antis
560-579 8465 AGUGAUUGGUAAUGGCUCA 8466 AGuGAuuGGuAAuGGcucAdTsdT
sense 560-579 8467 UGAGCCAUUACCAAUCACU 8468
UGAGCcAUuACcAAUcACUdTsdT antis 561-580 8469 GUGAUUGGUAAUGGCUCAU
8470 GuGAuuGGuAAuGGcucAudTsdT sense 561-580 8471
AUGAGCCAUUACCAAUCAC 8472 AUGAGCcAUuACcAAUcACdTsdT antis 622-641
8473 UGGUGGCCAUCAAGAAGGU 8474 uGGuGGccAucAAGAAGGudTsdT sense
622-641 8475 ACCUUCUUGAUGGCCACCA 8476 ACCUUCUUGAUGGCcACcAdTsdT
antis 628-647 8477 CCAUCAAGAAGGUUCUUCA 8478
ccAucAAGAAGGuucuucAdTsdT sense 628-647 8479 UGAAGAACCUUCUUGAUGG
8480 UGAAGAACCUUCUUGAUGGdTsdT antis 629-648 8481
CAUCAAGAAGGUUCUUCAG 8482 cAucAAGAAGGuucuucAGdTsdT sense 629-648
8483 CUGAAGAACCUUCUUGAUG 8484 CUGAAGAACCUUCUUGAUGdTsdT antis
637-656 8485 AGGUUCUUCAGGACAAAAG 8486 AGGuucuucAGGAcAAAAGdTsdT
sense 637-656 8487 CUUUUGUCCUGAAGAACCU 8488
CUUUUGUCCUGAAGAACCUdTsdT antis 684-703 8489 CGUAAGCUGGACCACUGCA
8490 cGuAAGcuGGAccAcuGcAdTsdT sense 684-703 8491
UGCAGUGGUCCAGCUUACG 8492 UGcAGUGGUCcAGCUuACGdTsdT antis 695-714
8493 CCACUGCAAUAUUGUGAGG 8494 ccAcuGcAAuAuuGuGAGGdTsdT sense
695-714 8495 CCUCACAAUAUUGCAGUGG 8496 CCUcAcAAuAUUGcAGUGGdTsdT
antis 719-738 8497 GUACUUUUUCUACUCCAGU 8498
GuAcuuuuucuAcuccAGudTsdT sense 719-738 8499 ACUGGAGUAGAAAAAGUAC
8500 ACUGGAGuAGAAAAAGuACdTsdT antis 722-741 8501
CUUUUUCUACUCCAGUGGG 8502 cuuuuucuAcuccAGuGGGdTsdT sense 722-741
8503 CCCACUGGAGUAGAAAAAG 8504 CCcACUGGAGuAGAAAAAGdTsdT antis
728-747 8505 CUACUCCAGUGGGGAGAAG 8506 cuAcuccAGuGGGGAGAAGdTsdT
sense 728-747 8507 CUUCUCCCCACUGGAGUAG 8508
CUUCUCCCcACUGGAGuAGdTsdT antis 732-751 8509 UCCAGUGGGGAGAAGAAGG
8510 uccAGuGGGGAGAAGAAGGdTsdT sense 732-751 8511
CCUUCUUCUCCCCACUGGA 8512 CCUUCUUCUCCCcACUGGAdTsdT antis 734-753
8513 CAGUGGGGAGAAGAAGGAC 8514 cAGuGGGGAGAAGAAGGAcdTsdT sense
734-753 8515 GUCCUUCUUCUCCCCACUG 8516 GUCCUUCUUCUCCCcACUGdTsdT
antis 735-754 8517 AGUGGGGAGAAGAAGGACG 8518
AGuGGGGAGAAGAAGGAcGdTsdT sense 735-754 8519 CGUCCUUCUUCUCCCCACU
8520 CGUCCUUCUUCUCCCcACUdTsdT antis 766-785 8521
AUCUGGUGCUGGAGUAUGU 8522 AucuGGuGcuGGAGuAuGudTsdT sense
766-785 8523 ACAUACUCCAGCACCAGAU 8524 AcAuACUCcAGcACcAGAUdTsdT
antis 767-786 8525 UCUGGUGCUGGAGUAUGUG 8526
ucuGGuGcuGGAGuAuGuGdTsdT sense 767-786 8527 CACAUACUCCAGCACCAGA
8528 cAcAuACUCcAGcACcAGAdTsdT antis 768-787 8529
CUGGUGCUGGAGUAUGUGC 8530 cuGGuGcuGGAGuAuGuGcdTsdT sense 768-787
8531 GCACAUACUCCAGCACCAG 8532 GcAcAuACUCcAGcACcAGdTsdT antis
812-831 8533 CCACUUCACCAAGGCCAAG 8534 ccAcuucAccAAGGccAAGdTsdT
sense 812-831 8535 CUUGGCCUUGGUGAAGUGG 8536
CUUGGCCUUGGUGAAGUGGdTsdT antis 814-833 8537 ACUUCACCAAGGCCAAGCU
8538 AcuucAccAAGGccAAGcudTsdT sense 814-833 8539
AGCUUGGCCUUGGUGAAGU 8540 AGCUUGGCCUUGGUGAAGUdTsdT antis 816-835
8541 UUCACCAAGGCCAAGCUGA 8542 uucAccAAGGccAAGcuGAdTsdT sense
816-835 8543 UCAGCUUGGCCUUGGUGAA 8544 UcAGCUUGGCCUUGGUGAAdTsdT
antis 819-838 8545 ACCAAGGCCAAGCUGAUCA 8546
AccAAGGccAAGcuGAucAdTsdT sense 819-838 8547 UGAUCAGCUUGGCCUUGGU
8548 UGAUcAGCUUGGCCUUGGUdTsdT antis 820-839 8549
CCAAGGCCAAGCUGAUCAC 8550 ccAAGGccAAGcuGAucAcdTsdT sense 820-839
8551 GUGAUCAGCUUGGCCUUGG 8552 GUGAUcAGCUUGGCCUUGGdTsdT antis
864-883 8553 AUGUACCAGCUCUUCCGGA 8554 AuGuAccAGcucuuccGGAdTsdT
sense 864-883 8555 UCCGGAAGAGCUGGUACAU 8556
UCCGGAAGAGCUGGuAcAUdTsdT antis 875-894 8557 CUUCCGGAGCUUGGCCUAC
8558 cuuccGGAGcuuGGccuAcdTsdT sense 875-894 8559
GUAGGCCAAGCUCCGGAAG 8560 GuAGGCcAAGCUCCGGAAGdTsdT antis 964-983
8561 UCCUCAAGCUCUGCGAUUU 8562 uccucAAGcucuGcGAuuudTsdT sense
964-983 8563 AAAUCGCAGAGCUUGAGGA 8564 AAAUCGcAGAGCUUGAGGAdTsdT
antis 965-984 8565 CCUCAAGCUCUGCGAUUUU 8566
ccucAAGcucuGcGAuuuudTsdT sense 965-984 8567 AAAAUCGCAGAGCUUGAGG
8568 AAAAUCGcAGAGCUUGAGGdTsdT antis 969-988 8569
AAGCUCUGCGAUUUUGGCA 8570 AAGcucuGcGAuuuuGGcAdTsdT sense 969-988
8571 UGCCAAAAUCGCAGAGCUU 8572 UGCcAAAAUCGcAGAGCUUdTsdT antis
980-999 8573 UUUUGGCAGUGCAAAGCAG 8574 uuuuGGcAGuGcAAAGcAGdTsdT
sense 980-999 8575 CUGCUUUGCACUGCCAAAA 8576
CUGCUUUGcACUGCcAAAAdTsdT antis 981-1000 8577 UUUGGCAGUGCAAAGCAGC
8578 uuuGGcAGuGcAAAGcAGcdTsdT sense 981-1000 8579
GCUGCUUUGCACUGCCAAA 8580 GCUGCUUUGcACUGCcAAAdTsdT antis 985-1004
8581 GCAGUGCAAAGCAGCUGGU 8582 GcAGuGcAAAGcAGcuGGudTsdT sense
985-1004 8583 ACCAGCUGCUUUGCACUGC 8584 ACcAGCUGCUUUGcACUGCdTsdT
antis 1166-1185 8585 GGUGGACCAGCUUGUGGAG 8586
GGuGGAccAGcuuGuGGAGdTsdT sense 1166-1185 8587 CUCCACAAGCUGGUCCACC
8588 CUCcAcAAGCUGGUCcACCdTsdT antis 1167-1186 8589
GUGGACCAGCUUGUGGAGA 8590 GuGGAccAGcuuGuGGAGAdTsdT sense 1167-1186
8591 UCUCCACAAGCUGGUCCAC 8592 UCUCcAcAAGCUGGUCcACdTsdT antis
1171-1190 8593 ACCAGCUUGUGGAGAUCAU 8594 AccAGcuuGuGGAGAucAudTsdT
sense 1171-1190 8595 AUGAUCUCCACAAGCUGGU 8596
AUGAUCUCcAcAAGCUGGUdTsdT antis 1211-1230 8597 CAGGGAACAAAUCCGAGAG
8598 cAGGGAAcAAAuccGAGAGdTsdT sense 1211-1230 8599
CUCUCGGAUUUGUUCCCUG 8600 CUCUCGGAUUUGUUCCCUGdTsdT antis 1254-1273
8601 AAGUUCCCCCAGAUCAAAG 8602 AAGuucccccAGAucAAAGdTsdT sense
1254-1273 8603 CUUUGAUCUGGGGGAACUU 8604 CUUUGAUCUGGGGGAACUUdTsdT
antis 1259-1278 8605 CCCCCAGAUCAAAGCUCAC 8606
cccccAGAucAAAGcucAcdTsdT sense 1259-1278 8607 GUGAGCUUUGAUCUGGGGG
8608 GUGAGCUUUGAUCUGGGGGdTsdT antis 1260-1279 8609
CCCCAGAUCAAAGCUCACC 8610 ccccAGAucAAAGcucAccdTsdT sense 1260-1279
8611 GGUGAGCUUUGAUCUGGGG 8612 GGUGAGCUUUGAUCUGGGGdTsdT antis
1281-1300 8613 UGGACAAAGGUGUUCAAAU 8614 uGGAcAAAGGuGuucAAAudTsdT
sense 1281-1300 8615 AUUUGAACACCUUUGUCCA 8616
AUUUGAAcACCUUUGUCcAdTsdT antis 1360-1379 8617 CCUCAAGGCUCUCCCCACU
8618 ccucAAGGcucuccccAcudTsdT sense 1360-1379 8619
AGUGGGGAGAGCCUUGAGG 8620 AGUGGGGAGAGCCUUGAGGdTsdT antis 1381-1400
8621 AGGCUUGUGCCCACAGCUU 8622 AGGcuuGuGcccAcAGcuudTsdT sense
1381-1400 8623 AAGCUGUGGGCACAAGCCU 8624 AAGCUGUGGGcAcAAGCCUdTsdT
antis 1385-1404 8625 UUGUGCCCACAGCUUCUUC 8626
uuGuGcccAcAGcuucuucdTsdT sense 1385-1404 8627 GAAGAAGCUGUGGGCACAA
8628 GAAGAAGCUGUGGGcAcAAdTsdT antis 1387-1406 8629
GUGCCCACAGCUUCUUCGA 8630 GuGcccAcAGcuucuucGAdTsdT sense 1387-1406
8631 UCGAAGAAGCUGUGGGCAC 8632 UCGAAGAAGCUGUGGGcACdTsdT antis
1388-1407 8633 UGCCCACAGCUUCUUCGAU 8634 uGcccAcAGcuucuucGAudTsdT
sense 1388-1407 8635 AUCGAAGAAGCUGUGGGCA 8636
AUCGAAGAAGCUGUGGGcAdTsdT antis 1455-1474 8637 CCCCUGUUCAACUUCAGUC
8638 ccccuGuucAAcuucAGucdTsdT sense 1455-1474 8639
GACUGAAGUUGAACAGGGG 8640 GACUGAAGUUGAAcAGGGGdTsdT antis 1456-1475
8641 CCCUGUUCAACUUCAGUCC 8642 cccuGuucAAcuucAGuccdTsdT sense
1456-1475 8643 GGACUGAAGUUGAACAGGG 8644 GGACUGAAGUUGAAcAGGGdTsdT
antis 1457-1476 8645 CCUGUUCAACUUCAGUCCU 8646
ccuGuucAAcuucAGuccudTsdT sense 1457-1476 8647 AGGACUGAAGUUGAACAGG
8648 AGGACUGAAGUUGAAcAGGdTsdT antis 1458-1477 8649
CUGUUCAACUUCAGUCCUG 8650 cuGuucAAcuucAGuccuGdTsdT sense 1458-1477
8651 CAGGACUGAAGUUGAACAG 8652 cAGGACUGAAGUUGAAcAGdTsdT antis
1513-1532 8653 UCAUCCCUCCUCACUUGAG 8654 ucAucccuccucAcuuGAGdTsdT
sense 1513-1532 8655 CUCAAGUGAGGAGGGAUGA 8656
CUcAAGUGAGGAGGGAUGAdTsdT antis 1514-1533 8657 CAUCCCUCCUCACUUGAGG
8658 cAucccuccucAcuuGAGGdTsdT sense 1514-1533 8659
CCUCAAGUGAGGAGGGAUG 8660 CCUcAAGUGAGGAGGGAUGdTsdT antis 1517-1536
8661 CCCUCCUCACUUGAGGUCC 8662 cccuccucAcuuGAGGuccdTsdT sense
1517-1536 8663 GGACCUCAAGUGAGGAGGG 8664 GGACCUcAAGUGAGGAGGGdTsdT
antis 1518-1537 8665 CCUCCUCACUUGAGGUCCC 8666
ccuccucAcuuGAGGucccdTsdT sense 1518-1537 8667 GGGACCUCAAGUGAGGAGG
8668 GGGACCUcAAGUGAGGAGGdTsdT antis 1519-1538 8669
CUCCUCACUUGAGGUCCCC 8670 cuccucAcuuGAGGuccccdTsdT sense 1519-1538
8671 GGGGACCUCAAGUGAGGAG 8672 GGGGACCUcAAGUGAGGAGdTsdT antis
1525-1544 8673 ACUUGAGGUCCCCAGCAGG 8674 AcuuGAGGuccccAGcAGGdTsdT
sense 1525-1544 8675 CCUGCUGGGGACCUCAAGU 8676
CCUGCUGGGGACCUcAAGUdTsdT antis 1526-1545 8677 CUUGAGGUCCCCAGCAGGC
8678 cuuGAGGuccccAGcAGGcdTsdT sense 1526-1545 8679
GCCUGCUGGGGACCUCAAG 8680 GCCUGCUGGGGACCUcAAGdTsdT antis 1527-1546
8681 UUGAGGUCCCCAGCAGGCC 8682 uuGAGGuccccAGcAGGccdTsdT sense
1527-1546 8683 GGCCUGCUGGGGACCUCAA 8684 GGCCUGCUGGGGACCUcAAdTsdT
antis 1530-1549 8685 AGGUCCCCAGCAGGCCCUG 8686
AGGuccccAGcAGGcccuGdTsdT sense 1530-1549 8687 CAGGGCCUGCUGGGGACCU
8688 cAGGGCCUGCUGGGGACCUdTsdT antis 1531-1550 8689
GGUCCCCAGCAGGCCCUGC 8690 GGuccccAGcAGGcccuGcdTsdT sense 1531-1550
8691 GCAGGGCCUGCUGGGGACC 8692 GcAGGGCCUGCUGGGGACCdTsdT antis
1532-1551 8693 GUCCCCAGCAGGCCCUGCU 8694 GuccccAGcAGGcccuGcudTsdT
sense 1532-1551 8695 AGCAGGGCCUGCUGGGGAC 8696
AGcAGGGCCUGCUGGGGACdTsdT antis 1538-1557 8697 AGCAGGCCCUGCUUCUCCC
8698 AGcAGGcccuGcuucucccdTsdT sense 1538-1557 8699
GGGAGAAGCAGGGCCUGCU 8700 GGGAGAAGcAGGGCCUGCUdTsdT antis 1588-1607
8701 CUUUAACUGAAGCUCAGAC 8702 cuuuAAcuGAAGcucAGAcdTsdT sense
1588-1607 8703 GUCUGAGCUUCAGUUAAAG 8704 GUCUGAGCUUcAGUuAAAGdTsdT
antis 1626-1645 8705 UCUGAUGCCACAACUGCUA 8706
ucuGAuGccAcAAcuGcuAdTsdT sense 1626-1645 8707 UAGCAGUUGUGGCAUCAGA
8708 uAGcAGUUGUGGcAUcAGAdTsdT antis 1627-1646 8709
CUGAUGCCACAACUGCUAC 8710 cuGAuGccAcAAcuGcuAcdTsdT sense 1627-1646
8711 GUAGCAGUUGUGGCAUCAG 8712 GuAGcAGUUGUGGcAUcAGdTsdT antis
1628-1647 8713 UGAUGCCACAACUGCUACC 8714 uGAuGccAcAAcuGcuAccdTsdT
sense 1628-1647 8715 GGUAGCAGUUGUGGCAUCA 8716
GGuAGcAGUUGUGGcAUcAdTsdT antis 1629-1648 8717 GAUGCCACAACUGCUACCC
8718 GAuGccAcAAcuGcuAcccdTsdT sense 1629-1648 8719
GGGUAGCAGUUGUGGCAUC 8720 GGGuAGcAGUUGUGGcAUCdTsdT antis 1686-1705
8721 CACGUCCAUCUGGGAAGGC 8722 cAcGuccAucuGGGAAGGcdTsdT sense
1686-1705 8723 GCCUUCCCAGAUGGACGUG 8724 GCCUUCCcAGAUGGACGUGdTsdT
antis 1687-1706 8725 ACGUCCAUCUGGGAAGGCC 8726
AcGuccAucuGGGAAGGccdTsdT sense 1687-1706 8727 GGCCUUCCCAGAUGGACGU
8728 GGCCUUCCcAGAUGGACGUdTsdT antis 1688-1707 8729
CGUCCAUCUGGGAAGGCCC 8730 cGuccAucuGGGAAGGcccdTsdT sense 1688-1707
8731 GGGCCUUCCCAGAUGGACG 8732 GGGCCUUCCcAGAUGGACGdTsdT antis
1689-1708 8733 GUCCAUCUGGGAAGGCCCA 8734 GuccAucuGGGAAGGcccAdTsdT
sense 1689-1708 8735 UGGGCCUUCCCAGAUGGAC 8736
UGGGCCUUCCcAGAUGGACdTsdT antis 1694-1713 8737 UCUGGGAAGGCCCAAGUGG
8738 ucuGGGAAGGcccAAGuGGdTsdT sense 1694-1713 8739
CCACUUGGGCCUUCCCAGA 8740 CcACUUGGGCCUUCCcAGAdTsdT antis 1695-1714
8741 CUGGGAAGGCCCAAGUGGC 8742 cuGGGAAGGcccAAGuGGcdTsdT sense
1695-1714 8743 GCCACUUGGGCCUUCCCAG 8744 GCcACUUGGGCCUUCCcAGdTsdT
antis 1709-1728 8745 GUGGCGCUGGGAAGGGGGC 8746
GuGGcGcuGGGAAGGGGGcdTsdT sense 1709-1728 8747 GCCCCCUUCCCAGCGCCAC
8748 GCCCCCUUCCcAGCGCcACdTsdT antis 1714-1733 8749
GCUGGGAAGGGGGCCACAG 8750 GcuGGGAAGGGGGccAcAGdTsdT sense 1714-1733
8751 CUGUGGCCCCCUUCCCAGC 8752 CUGUGGCCCCCUUCCcAGCdTsdT antis
1722-1741 8753 GGGGGCCACAGCCCAUCAA 8754 GGGGGccAcAGcccAucAAdTsdT
sense 1722-1741 8755 UUGAUGGGCUGUGGCCCCC 8756
UUGAUGGGCUGUGGCCCCCdTsdT antis 1723-1742 8757 GGGGCCACAGCCCAUCAAG
8758 GGGGccAcAGcccAucAAGdTsdT sense 1723-1742 8759
CUUGAUGGGCUGUGGCCCC 8760 CUUGAUGGGCUGUGGCCCCdTsdT antis 1732-1751
8761 GCCCAUCAAGCUCCUGCCC 8762 GcccAucAAGcuccuGcccdTsdT sense
1732-1751 8763 GGGCAGGAGCUUGAUGGGC 8764 GGGcAGGAGCUUGAUGGGCdTsdT
antis 1737-1756 8765 UCAAGCUCCUGCCCUGGCU 8766
ucAAGcuccuGcccuGGcudTsdT sense 1737-1756 8767 AGCCAGGGCAGGAGCUUGA
8768 AGCcAGGGcAGGAGCUUGAdTsdT antis 1743-1762 8769
UCCUGCCCUGGCUGGGCCC 8770 uccuGcccuGGcuGGGcccdTsdT sense 1743-1762
8771 GGGCCCAGCCAGGGCAGGA 8772 GGGCCcAGCcAGGGcAGGAdTsdT antis
1744-1763 8773 CCUGCCCUGGCUGGGCCCC 8774 ccuGcccuGGcuGGGccccdTsdT
sense 1744-1763 8775 GGGGCCCAGCCAGGGCAGG 8776
GGGGCCcAGCcAGGGcAGGdTsdT antis 1746-1765 8777 UGCCCUGGCUGGGCCCCUA
8778 uGcccuGGcuGGGccccuAdTsdT sense 1746-1765 8779
UAGGGGCCCAGCCAGGGCA 8780 uAGGGGCCcAGCcAGGGcAdTsdT antis 1748-1767
8781 CCCUGGCUGGGCCCCUAGA 8782 cccuGGcuGGGccccuAGAdTsdT sense
1748-1767 8783 UCUAGGGGCCCAGCCAGGG 8784 UCuAGGGGCCcAGCcAGGGdTsdT
antis 1769-1788 8785 AGAGGGCAGAGGUAAAUGA 8786
AGAGGGcAGAGGuAAAuGAdTsdT sense 1769-1788 8787 UCAUUUACCUCUGCCCUCU
8788 UcAUUuACCUCUGCCCUCUdTsdT antis 1770-1789 8789
GAGGGCAGAGGUAAAUGAA 8790 GAGGGcAGAGGuAAAuGAAdTsdT sense 1770-1789
8791 UUCAUUUACCUCUGCCCUC 8792 UUcAUUuACCUCUGCCCUCdTsdT antis
1798-1817 8793 GCAUCUAGGCCUCCCUCAG 8794 GcAucuAGGccucccucAGdTsdT
sense 1798-1817 8795 CUGAGGGAGGCCUAGAUGC 8796
CUGAGGGAGGCCuAGAUGCdTsdT antis 1825-1844 8797 CCUCUGUGGUGGGCUUUUU
8798 ccucuGuGGuGGGcuuuuudTsdT sense 1825-1844 8799
AAAAAGCCCACCACAGAGG 8800 AAAAAGCCcACcAcAGAGGdTsdT antis 1831-1850
8801 UGGUGGGCUUUUUAAAGAG 8802 uGGuGGGcuuuuuAAAGAGdTsdT sense
1831-1850 8803 CUCUUUAAAAAGCCCACCA 8804 CUCUUuAAAAAGCCcACcAdTsdT
antis 1833-1852 8805 GUGGGCUUUUUAAAGAGGA 8806
GuGGGcuuuuuAAAGAGGAdTsdT sense 1833-1852 8807 UCCUCUUUAAAAAGCCCAC
8808 UCCUCUUuAAAAAGCCcACdTsdT antis 1837-1856 8809
GCUUUUUAAAGAGGAUUUU 8810 GcuuuuuAAAGAGGAuuuudTsdT sense 1837-1856
8811 AAAAUCCUCUUUAAAAAGC 8812 AAAAUCCUCUUuAAAAAGCdTsdT antis
1838-1857 8813 CUUUUUAAAGAGGAUUUUA 8814 cuuuuuAAAGAGGAuuuuAdTsdT
sense 1838-1857 8815 UAAAAUCCUCUUUAAAAAG 8816
uAAAAUCCUCUUuAAAAAGdTsdT antis 1869-1888 8817 GGAGGGGAGAAAAGGAAGG
8818 GGAGGGGAGAAAAGGAAGGdTsdT sense 1869-1888 8819
CCUUCCUUUUCUCCCCUCC 8820 CCUUCCUUUUCUCCCCUCCdTsdT antis 1870-1889
8821 GAGGGGAGAAAAGGAAGGA 8822 GAGGGGAGAAAAGGAAGGAdTsdT sense
1870-1889 8823 UCCUUCCUUUUCUCCCCUC 8824 UCCUUCCUUUUCUCCCCUCdTsdT
antis 1888-1907 8825 ACGGGGUUUGGGGGUGUGA 8826
AcGGGGuuuGGGGGuGuGAdTsdT sense 1888-1907 8827 UCACACCCCCAAACCCCGU
8828 UcAcACCCCcAAACCCCGUdTsdT antis 1923-1942 8829
UGGUCCCCUCCCCUCCCCC 8830 uGGuccccuccccucccccdTsdT sense 1923-1942
8831 GGGGGAGGGGAGGGGACCA 8832 GGGGGAGGGGAGGGGACcAdTsdT antis
1924-1943 8833 GGUCCCCUCCCCUCCCCCA 8834 GGuccccuccccucccccAdTsdT
sense 1924-1943 8835 UGGGGGAGGGGAGGGGACC 8836
UGGGGGAGGGGAGGGGACCdTsdT antis 1931-1950 8837 UCCCCUCCCCCAGGCUACC
8838 uccccucccccAGGcuAccdTsdT sense 1931-1950 8839
GGUAGCCUGGGGGAGGGGA 8840 GGuAGCCUGGGGGAGGGGAdTsdT antis 1962-1981
8841 CCCCCCUCUCCCAGGUCCC 8842 ccccccucucccAGGucccdTsdT sense
1962-1981 8843 GGGACCUGGGAGAGGGGGG 8844 GGGACCUGGGAGAGGGGGGdTsdT
antis 1963-1982 8845 CCCCCUCUCCCAGGUCCCU 8846
cccccucucccAGGucccudTsdT sense 1963-1982 8847 AGGGACCUGGGAGAGGGGG
8848 AGGGACCUGGGAGAGGGGGdTsdT antis 2132-2151 8849
CCAAGGCUUCCUCCCUCUC 8850 ccAAGGcuuccucccucucdTsdT sense 2132-2151
8851 GAGAGGGAGGAAGCCUUGG 8852 GAGAGGGAGGAAGCCUUGGdTsdT antis
2139-2158 8853 UUCCUCCCUCUCCCCAUCC 8854 uuccucccucuccccAuccdTsdT
sense 2139-2158 8855 GGAUGGGGAGAGGGAGGAA 8856
GGAUGGGGAGAGGGAGGAAdTsdT antis 63-82 8857 UGGGCCGGAGCCGGAGCCC 8858
uGGGccGGAGccGGAGcccdTsdT sense 63-82 8859 GGGCUCCGGCUCCGGCCCA 8860
GGGCUCCGGCUCCGGCCcAdTsdT antis 65-84 8861 GGCCGGAGCCGGAGCCCGA 8862
GGccGGAGccGGAGcccGAdTsdT sense 65-84 8863 UCGGGCUCCGGCUCCGGCC 8864
UCGGGCUCCGGCUCCGGCCdTsdT antis 66-85 8865 GCCGGAGCCGGAGCCCGAA 8866
GccGGAGccGGAGcccGAAdTsdT sense 66-85 8867 UUCGGGCUCCGGCUCCGGC 8868
UUCGGGCUCCGGCUCCGGCdTsdT antis 115-134 8869 GGGAGGCGGCGGCAGAGGC
8870 GGGAGGcGGcGGcAGAGGcdTsdT sense 115-134 8871
GCCUCUGCCGCCGCCUCCC 8872 GCCUCUGCCGCCGCCUCCCdTsdT antis 118-137
8873 AGGCGGCGGCAGAGGCAGC 8874 AGGcGGcGGcAGAGGcAGcdTsdT sense
118-137 8875 GCUGCCUCUGCCGCCGCCU 8876 GCUGCCUCUGCCGCCGCCUdTsdT
antis 119-138 8877 GGCGGCGGCAGAGGCAGCG 8878
GGcGGcGGcAGAGGcAGcGdTsdT sense 119-138 8879 CGCUGCCUCUGCCGCCGCC
8880 CGCUGCCUCUGCCGCCGCCdTsdT antis 128-147 8881
AGAGGCAGCGGCGGGGGCA 8882 AGAGGcAGcGGcGGGGGcAdTsdT sense 128-147
8883 UGCCCCCGCCGCUGCCUCU 8884 UGCCCCCGCCGCUGCCUCUdTsdT antis
129-148 8885 GAGGCAGCGGCGGGGGCAG 8886 GAGGcAGcGGcGGGGGcAGdTsdT
sense 129-148 8887 CUGCCCCCGCCGCUGCCUC 8888
CUGCCCCCGCCGCUGCCUCdTsdT antis 265-284 8889 CAGGAGGCGGAGGCGGAGG
8890 cAGGAGGcGGAGGcGGAGGdTsdT sense 265-284 8891
CCUCCGCCUCCGCCUCCUG 8892 CCUCCGCCUCCGCCUCCUGdTsdT antis 266-285
8893 AGGAGGCGGAGGCGGAGGU 8894 AGGAGGcGGAGGcGGAGGudTsdT sense
266-285 8895 ACCUCCGCCUCCGCCUCCU 8896 ACCUCCGCCUCCGCCUCCUdTsdT
antis 269-288 8897 AGGCGGAGGCGGAGGUGGU 8898
AGGcGGAGGcGGAGGuGGudTsdT sense 269-288 8899 ACCACCUCCGCCUCCGCCU
8900 ACcACCUCCGCCUCCGCCUdTsdT antis 275-294 8901
AGGCGGAGGUGGUGGCGGC 8902 AGGcGGAGGuGGuGGcGGcdTsdT sense 275-294
8903 GCCGCCACCACCUCCGCCU 8904 GCCGCcACcACCUCCGCCUdTsdT antis
278-297 8905 CGGAGGUGGUGGCGGCGGC 8906 cGGAGGuGGuGGcGGcGGcdTsdT
sense 278-297 8907 GCCGCCGCCACCACCUCCG 8908
GCCGCCGCcACcACCUCCGdTsdT antis 279-298 8909 GGAGGUGGUGGCGGCGGCC
8910 GGAGGuGGuGGcGGcGGccdTsdT sense 279-298 8911
GGCCGCCGCCACCACCUCC 8912 GGCCGCCGCcACcACCUCCdTsdT antis 314-333
8913 UGGCCCAGGAGGCACUGGC 8914 uGGcccAGGAGGcAcuGGcdTsdT sense
314-333 8915 GCCAGUGCCUCCUGGGCCA 8916 GCcAGUGCCUCCUGGGCcAdTsdT
antis 399-418 8917 AGCGGCAGCGGCGGAGGAG 8918
AGcGGcAGcGGcGGAGGAGdTsdT sense 399-418 8919 CUCCUCCGCCGCUGCCGCU
8920 CUCCUCCGCCGCUGCCGCUdTsdT antis 411-430 8921
GGAGGAGGCAGCGGUGGCC 8922 GGAGGAGGcAGcGGuGGccdTsdT sense 411-430
8923 GGCCACCGCUGCCUCCUCC 8924 GGCcACCGCUGCCUCCUCCdTsdT antis
412-431 8925 GAGGAGGCAGCGGUGGCCC 8926 GAGGAGGcAGcGGuGGcccdTsdT
sense 412-431 8927 GGGCCACCGCUGCCUCCUC 8928
GGGCcACCGCUGCCUCCUCdTsdT antis 413-432 8929 AGGAGGCAGCGGUGGCCCC
8930 AGGAGGcAGcGGuGGccccdTsdT sense 413-432 8931
GGGGCCACCGCUGCCUCCU 8932 GGGGCcACCGCUGCCUCCUdTsdT antis 414-433
8933 GGAGGCAGCGGUGGCCCCG 8934 GGAGGcAGcGGuGGccccGdTsdT sense
414-433 8935 CGGGGCCACCGCUGCCUCC 8936 CGGGGCcACCGCUGCCUCCdTsdT
antis 636-655 8937 AAGGUUCUUCAGGACAAAA 8938
AAGGuucuucAGGAcAAAAdTsdT sense 636-655 8939 UUUUGUCCUGAAGAACCUU
8940 UUUUGUCCUGAAGAACCUUdTsdT antis 731-750 8941
CUCCAGUGGGGAGAAGAAG 8942 cuccAGuGGGGAGAAGAAGdTsdT sense 731-750
8943 CUUCUUCUCCCCACUGGAG 8944 CUUCUUCUCCCcACUGGAGdTsdT antis
733-752 8945 CCAGUGGGGAGAAGAAGGA 8946 ccAGuGGGGAGAAGAAGGAdTsdT
sense 733-752 8947 UCCUUCUUCUCCCCACUGG 8948
UCCUUCUUCUCCCcACUGGdTsdT antis 963-982 8949 GUCCUCAAGCUCUGCGAUU
8950 GuccucAAGcucuGcGAuudTsdT sense 963-982 8951
AAUCGCAGAGCUUGAGGAC 8952 AAUCGcAGAGCUUGAGGACdTsdT antis 1535-1554
8953 CCCAGCAGGCCCUGCUUCU 8954 cccAGcAGGcccuGcuucudTsdT sense
1535-1554 8955 AGAAGCAGGGCCUGCUGGG 8956 AGAAGcAGGGCCUGCUGGGdTsdT
antis 1536-1555 8957 CCAGCAGGCCCUGCUUCUC 8958
ccAGcAGGcccuGcuucucdTsdT sense 1536-1555 8959 GAGAAGCAGGGCCUGCUGG
8960 GAGAAGcAGGGCCUGCUGGdTsdT antis 1537-1556 8961
CAGCAGGCCCUGCUUCUCC 8962 cAGcAGGcccuGcuucuccdTsdT sense 1537-1556
8963 GGAGAAGCAGGGCCUGCUG 8964 GGAGAAGcAGGGCCUGCUGdTsdT antis
1887-1906 8965 GACGGGGUUUGGGGGUGUG 8966 GAcGGGGuuuGGGGGuGuGdTsdT
sense 1887-1906 8967 CACACCCCCAAACCCCGUC 8968
cAcACCCCcAAACCCCGUCdTsdT antis 1925-1944 8969 GUCCCCUCCCCUCCCCCAG
8970 GuccccuccccucccccAGdTsdT sense 1925-1944 8971
CUGGGGGAGGGGAGGGGAC 8972 CUGGGGGAGGGGAGGGGACdTsdT antis 1926-1945
8973 UCCCCUCCCCUCCCCCAGG 8974 uccccuccccucccccAGGdTsdT sense
1926-1945 8975 CCUGGGGGAGGGGAGGGGA 8976 CCUGGGGGAGGGGAGGGGAdTsdT
antis 2055-2074 8977 AUUUUUUCUUAAAGAAAAC 8978
AuuuuuucuuAAAGAAAAcdTsdT sense 2055-2074 8979 GUUUUCUUUAAGAAAAAAU
8980 GUUUUCUUuAAGAAAAAAUdTsdT antis 2143-2162 8981
UCCCUCUCCCCAUCCUGGA 8982 ucccucuccccAuccuGGAdTsdT sense 2143-2162
8983 UCCAGGAUGGGGAGAGGGA 8984 UCcAGGAUGGGGAGAGGGAdTsdT antis
TABLE-US-00004 TABLE 2 Sequences of duplexes targeting Mouse
GSK3-beta Sequences of duplexes targeting mouse GSK3-beta. Target
sequence location identifies target sequence in mouse GSK3-beta
mRNA NM_019827.6. Sense strand is identical to target sequence.
Antisense strand is complementary to target sequence. Target SEQ
SEQ sequence ID Unmodified sequence ID Modified sequence location
NO: 5' to 3' NO: 5' to 3' Strand 1842-1861 8985 ACUGUAACAUAGUCCGACU
10985 AcuGuAAcAuAGuccGAcudTsdT sense 1842-1861 8986
AGUCGGACUAUGUUACAGU 10986 AGUCGGACuAUGUuAcAGUdTsdT antis 1843-1862
8987 CUGUAACAUAGUCCGACUG 10987 cuGuAAcAuAGuccGAcuGdTsdT sense
1843-1862 8988 CAGUCGGACUAUGUUACAG 10988 cAGUCGGACuAUGUuAcAGdTsdT
antis 1952-1971 8989 GCCAGACACUAUAGUCGAG 10989
GccAGAcAcuAuAGucGAGdTsdT sense 1952-1971 8990 CUCGACUAUAGUGUCUGGC
10990 CUCGACuAuAGUGUCUGGCdTsdT antis 1847-1866 8991
AACAUAGUCCGACUGCGGU 10991 AAcAuAGuccGAcuGcGGudTsdT sense 1847-1866
8992 ACCGCAGUCGGACUAUGUU 10992 ACCGcAGUCGGACuAUGUUdTsdT antis
1838-1857 8993 GACCACUGUAACAUAGUCC 10993 GAccAcuGuAAcAuAGuccdTsdT
sense 1838-1857 8994 GGACUAUGUUACAGUGGUC 10994
GGACuAUGUuAcAGUGGUCdTsdT antis 1846-1865 8995 UAACAUAGUCCGACUGCGG
10995 uAAcAuAGuccGAcuGcGGdTsdT sense 1846-1865 8996
CCGCAGUCGGACUAUGUUA 10996 CCGcAGUCGGACuAUGUuAdTsdT antis 1849-1868
8997 CAUAGUCCGACUGCGGUAU 10997 cAuAGuccGAcuGcGGuAudTsdT sense
1849-1868 8998 AUACCGCAGUCGGACUAUG 10998 AuACCGcAGUCGGACuAUGdTsdT
antis 1955-1974 8999 AGACACUAUAGUCGAGCCA 10999
AGAcAcuAuAGucGAGccAdTsdT sense 1955-1974 9000 UGGCUCGACUAUAGUGUCU
11000 UGGCUCGACuAuAGUGUCUdTsdT antis 1957-1976 9001
ACACUAUAGUCGAGCCAAG 11001 AcAcuAuAGucGAGccAAGdTsdT sense 1957-1976
9002 CUUGGCUCGACUAUAGUGU 11002 CUUGGCUCGACuAuAGUGUdTsdT antis
2169-2188 9003 CAUAUAUCUGUUCUCGGUA 11003 cAuAuAucuGuucucGGuAdTsdT
sense 2169-2188 9004 UACCGAGAACAGAUAUAUG 11004
uACCGAGAAcAGAuAuAUGdTsdT antis 1788-1807 9005 UACAGGACAAGCGAUUUAA
11005 uAcAGGAcAAGcGAuuuAAdTsdT sense 1788-1807 9006
UUAAAUCGCUUGUCCUGUA 11006 UuAAAUCGCUUGUCCUGuAdTsdT antis 1862-1881
9007 CGGUAUUUCUUCUACUCGA 11007 cGGuAuuucuucuAcucGAdTsdT sense
1862-1881 9008 UCGAGUAGAAGAAAUACCG 11008 UCGAGuAGAAGAAAuACCGdTsdT
antis 2021-2040 9009 UUCAGAAGUCUAGCCUAUA 11009
uucAGAAGucuAGccuAuAdTsdT sense 2021-2040 9010 UAUAGGCUAGACUUCUGAA
11010 uAuAGGCuAGACUUCUGAAdTsdT antis 1863-1882 9011
GGUAUUUCUUCUACUCGAG 11011 GGuAuuucuucuAcucGAGdTsdT sense 1863-1882
9012 CUCGAGUAGAAGAAAUACC 11012 CUCGAGuAGAAGAAAuACCdTsdT antis
2496-2515 9013 CACCUACCGCCCGGCUAAC 11013 cAccuAccGcccGGcuAAcdTsdT
sense 2496-2515 9014 GUUAGCCGGGCGGUAGGUG 11014
GUuAGCCGGGCGGuAGGUGdTsdT antis 1796-1815 9015 AAGCGAUUUAAGAACCGAG
11015 AAGcGAuuuAAGAAccGAGdTsdT sense 1796-1815 9016
CUCGGUUCUUAAAUCGCUU 11016 CUCGGUUCUuAAAUCGCUUdTsdT antis 1844-1863
9017 UGUAACAUAGUCCGACUGC 11017 uGuAAcAuAGuccGAcuGcdTsdT sense
1844-1863 9018 GCAGUCGGACUAUGUUACA 11018 GcAGUCGGACuAUGUuAcAdTsdT
antis 2221-2240 9019 UGAUUACACGUCCAGUAUA 11019
uGAuuAcAcGuccAGuAuAdTsdT sense 2221-2240 9020 UAUACUGGACGUGUAAUCA
11020 uAuACUGGACGUGuAAUcAdTsdT antis 2228-2247 9021
ACGUCCAGUAUAGAUGUAU 11021 AcGuccAGuAuAGAuGuAudTsdT sense 2228-2247
9022 AUACAUCUAUACUGGACGU 11022 AuAcAUCuAuACUGGACGUdTsdT antis
1697-1716 9023 GACACGAAAGUGAUUGGAA 11023 GAcAcGAAAGuGAuuGGAAdTsdT
sense 1697-1716 9024 UUCCAAUCACUUUCGUGUC 11024
UUCcAAUcACUUUCGUGUCdTsdT antis 1845-1864 9025 GUAACAUAGUCCGACUGCG
11025 GuAAcAuAGuccGAcuGcGdTsdT sense 1845-1864 9026
CGCAGUCGGACUAUGUUAC 11026 CGcAGUCGGACuAUGUuACdTsdT antis 1851-1870
9027 UAGUCCGACUGCGGUAUUU 11027 uAGuccGAcuGcGGuAuuudTsdT sense
1851-1870 9028 AAAUACCGCAGUCGGACUA 11028 AAAuACCGcAGUCGGACuAdTsdT
antis 1871-1890 9029 UUCUACUCGAGUGGUGAGA 11029
uucuAcucGAGuGGuGAGAdTsdT sense 1871-1890 9030 UCUCACCACUCGAGUAGAA
11030 UCUcACcACUCGAGuAGAAdTsdT antis 2022-2041 9031
UCAGAAGUCUAGCCUAUAU 11031 ucAGAAGucuAGccuAuAudTsdT sense 2022-2041
9032 AUAUAGGCUAGACUUCUGA 11032 AuAuAGGCuAGACUUCUGAdTsdT antis
2024-2043 9033 AGAAGUCUAGCCUAUAUCC 11033 AGAAGucuAGccuAuAuccdTsdT
sense 2024-2043 9034 GGAUAUAGGCUAGACUUCU 11034
GGAuAuAGGCuAGACUUCUdTsdT antis 2220-2239 9035 CUGAUUACACGUCCAGUAU
11035 cuGAuuAcAcGuccAGuAudTsdT sense 2220-2239 9036
AUACUGGACGUGUAAUCAG 11036 AuACUGGACGUGuAAUcAGdTsdT antis 1789-1808
9037 ACAGGACAAGCGAUUUAAG 11037 AcAGGAcAAGcGAuuuAAGdTsdT sense
1789-1808 9038 CUUAAAUCGCUUGUCCUGU 11038 CUuAAAUCGCUUGUCCUGUdTsdT
antis 1922-1941 9039 GACUAUGUUCCGGAGACAG 11039
GAcuAuGuuccGGAGAcAGdTsdT sense 1922-1941 9040 CUGUCUCCGGAACAUAGUC
11040 CUGUCUCCGGAAcAuAGUCdTsdT antis 2020-2039 9041
GUUCAGAAGUCUAGCCUAU 11041 GuucAGAAGucuAGccuAudTsdT sense 2020-2039
9042 AUAGGCUAGACUUCUGAAC 11042 AuAGGCuAGACUUCUGAACdTsdT antis
2492-2511 9043 UACACACCUACCGCCCGGC 11043 uAcAcAccuAccGcccGGcdTsdT
sense 2492-2511 9044 GCCGGGCGGUAGGUGUGUA 11044
GCCGGGCGGuAGGUGUGuAdTsdT antis 1678-1697 9045 ACAGGAAGUCAGUUAUACA
11045 AcAGGAAGucAGuuAuAcAdTsdT sense 1678-1697 9046
UGUAUAACUGACUUCCUGU 11046 UGuAuAACUGACUUCCUGUdTsdT antis 1840-1859
9047 CCACUGUAACAUAGUCCGA 11047 ccAcuGuAAcAuAGuccGAdTsdT sense
1840-1859 9048 UCGGACUAUGUUACAGUGG 11048 UCGGACuAUGUuAcAGUGGdTsdT
antis 2487-2506 9049 UGGAGUACACACCUACCGC 11049
uGGAGuAcAcAccuAccGcdTsdT sense 2487-2506 9050 GCGGUAGGUGUGUACUCCA
11050 GCGGuAGGUGUGuACUCcAdTsdT antis 1924-1943 9051
CUAUGUUCCGGAGACAGUG 11051 cuAuGuuccGGAGAcAGuGdTsdT sense 1924-1943
9052 CACUGUCUCCGGAACAUAG 11052 cACUGUCUCCGGAAcAuAGdTsdT antis
2176-2195 9053 CUGUUCUCGGUACUACAGG 11053 cuGuucucGGuAcuAcAGGdTsdT
sense 2176-2195 9054 CCUGUAGUACCGAGAACAG 11054
CCUGuAGuACCGAGAAcAGdTsdT antis 2177-2196 9055 UGUUCUCGGUACUACAGGG
11055 uGuucucGGuAcuAcAGGGdTsdT sense 2177-2196 9056
CCCUGUAGUACCGAGAACA 11056 CCCUGuAGuACCGAGAAcAdTsdT antis 2502-2521
9057 CCGCCCGGCUAACACCACU 11057 ccGcccGGcuAAcAccAcudTsdT sense
2502-2521 9058 AGUGGUGUUAGCCGGGCGG 11058 AGUGGUGUuAGCCGGGCGGdTsdT
antis 2499-2518 9059 CUACCGCCCGGCUAACACC 11059
cuAccGcccGGcuAAcAccdTsdT sense 2499-2518 9060 GGUGUUAGCCGGGCGGUAG
11060 GGUGUuAGCCGGGCGGuAGdTsdT antis 2223-2242 9061
AUUACACGUCCAGUAUAGA 11061 AuuAcAcGuccAGuAuAGAdTsdT sense 2223-2242
9062 UCUAUACUGGACGUGUAAU 11062 UCuAuACUGGACGUGuAAUdTsdT antis
1873-1892 9063 CUACUCGAGUGGUGAGAAG 11063 cuAcucGAGuGGuGAGAAGdTsdT
sense 1873-1892 9064 CUUCUCACCACUCGAGUAG 11064
CUUCUcACcACUCGAGuAGdTsdT antis 1918-1937 9065 GCUGGACUAUGUUCCGGAG
11065 GcuGGAcuAuGuuccGGAGdTsdT sense 1918-1937 9066
CUCCGGAACAUAGUCCAGC 11066 CUCCGGAAcAuAGUCcAGCdTsdT antis 1919-1938
9067 CUGGACUAUGUUCCGGAGA 11067 cuGGAcuAuGuuccGGAGAdTsdT sense
1919-1938 9068 UCUCCGGAACAUAGUCCAG 11068 UCUCCGGAAcAuAGUCcAGdTsdT
antis 1950-1969 9069 UCGCCAGACACUAUAGUCG 11069
ucGccAGAcAcuAuAGucGdTsdT sense 1950-1969 9070 CGACUAUAGUGUCUGGCGA
11070 CGACuAuAGUGUCUGGCGAdTsdT antis 1958-1977 9071
CACUAUAGUCGAGCCAAGC 11071 cAcuAuAGucGAGccAAGcdTsdT sense 1958-1977
9072 GCUUGGCUCGACUAUAGUG 11072 GCUUGGCUCGACuAuAGUGdTsdT antis
2222-2241 9073 GAUUACACGUCCAGUAUAG 11073 GAuuAcAcGuccAGuAuAGdTsdT
sense 2222-2241 9074 CUAUACUGGACGUGUAAUC 11074
CuAuACUGGACGUGuAAUCdTsdT antis 2224-2243 9075 UUACACGUCCAGUAUAGAU
11075 uuAcAcGuccAGuAuAGAudTsdT sense 2224-2243 9076
AUCUAUACUGGACGUGUAA 11076 AUCuAuACUGGACGUGuAAdTsdT antis 2440-2459
9077 CCGGCCCCGAACUCCACCA 11077 ccGGccccGAAcuccAccAdTsdT sense
2440-2459 9078 UGGUGGAGUUCGGGGCCGG 11078 UGGUGGAGUUCGGGGCCGGdTsdT
antis 2493-2512 9079 ACACACCUACCGCCCGGCU 11079
AcAcAccuAccGcccGGcudTsdT sense 2493-2512 9080 AGCCGGGCGGUAGGUGUGU
11080 AGCCGGGCGGuAGGUGUGUdTsdT antis 2494-2513 9081
CACACCUACCGCCCGGCUA 11081 cAcAccuAccGcccGGcuAdTsdT sense 2494-2513
9082 UAGCCGGGCGGUAGGUGUG 11082 uAGCCGGGCGGuAGGUGUGdTsdT antis
2497-2516 9083 ACCUACCGCCCGGCUAACA 11083 AccuAccGcccGGcuAAcAdTsdT
sense 2497-2516 9084 UGUUAGCCGGGCGGUAGGU 11084
UGUuAGCCGGGCGGuAGGUdTsdT antis 2498-2517 9085 CCUACCGCCCGGCUAACAC
11085 ccuAccGcccGGcuAAcAcdTsdT sense 2498-2517 9086
GUGUUAGCCGGGCGGUAGG 11086 GUGUuAGCCGGGCGGuAGGdTsdT antis 1525-1544
9087 CAUGUCGGGGCGACCGAGA 11087 cAuGucGGGGcGAccGAGAdTsdT sense
1525-1544 9088 UCUCGGUCGCCCCGACAUG 11088 UCUCGGUCGCCCCGAcAUGdTsdT
antis 1528-1547 9089 GUCGGGGCGACCGAGAACC 11089
GucGGGGcGAccGAGAAccdTsdT sense 1528-1547 9090 GGUUCUCGGUCGCCCCGAC
11090 GGUUCUCGGUCGCCCCGACdTsdT antis 1533-1552 9091
GGCGACCGAGAACCACCUC 11091 GGcGAccGAGAAccAccucdTsdT sense 1533-1552
9092 GAGGUGGUUCUCGGUCGCC 11092 GAGGUGGUUCUCGGUCGCCdTsdT antis
1793-1812 9093 GACAAGCGAUUUAAGAACC 11093 GAcAAGcGAuuuAAGAAccdTsdT
sense 1793-1812 9094 GGUUCUUAAAUCGCUUGUC 11094
GGUUCUuAAAUCGCUUGUCdTsdT antis 1797-1816 9095 AGCGAUUUAAGAACCGAGA
11095 AGcGAuuuAAGAAccGAGAdTsdT sense 1797-1816 9096
UCUCGGUUCUUAAAUCGCU 11096 UCUCGGUUCUuAAAUCGCUdTsdT antis 1798-1817
9097 GCGAUUUAAGAACCGAGAG 11097 GcGAuuuAAGAAccGAGAGdTsdT sense
1798-1817 9098 CUCUCGGUUCUUAAAUCGC 11098 CUCUCGGUUCUuAAAUCGCdTsdT
antis 1799-1818 9099 CGAUUUAAGAACCGAGAGC 11099
cGAuuuAAGAAccGAGAGcdTsdT sense 1799-1818 9100 GCUCUCGGUUCUUAAAUCG
11100 GCUCUCGGUUCUuAAAUCGdTsdT antis 1832-1851 9101
AAGCUAGACCACUGUAACA 11101 AAGcuAGAccAcuGuAAcAdTsdT sense 1832-1851
9102 UGUUACAGUGGUCUAGCUU 11102 UGUuAcAGUGGUCuAGCUUdTsdT antis
1836-1855 9103 UAGACCACUGUAACAUAGU 11103 uAGAccAcuGuAAcAuAGudTsdT
sense 1836-1855 9104 ACUAUGUUACAGUGGUCUA 11104
ACuAUGUuAcAGUGGUCuAdTsdT antis
1850-1869 9105 AUAGUCCGACUGCGGUAUU 11105 AuAGuccGAcuGcGGuAuudTsdT
sense 1850-1869 9106 AAUACCGCAGUCGGACUAU 11106
AAuACCGcAGUCGGACuAUdTsdT antis 1852-1871 9107 AGUCCGACUGCGGUAUUUC
11107 AGuccGAcuGcGGuAuuucdTsdT sense 1852-1871 9108
GAAAUACCGCAGUCGGACU 11108 GAAAuACCGcAGUCGGACUdTsdT antis 1853-1872
9109 GUCCGACUGCGGUAUUUCU 11109 GuccGAcuGcGGuAuuucudTsdT sense
1853-1872 9110 AGAAAUACCGCAGUCGGAC 11110 AGAAAuACCGcAGUCGGACdTsdT
antis 1855-1874 9111 CCGACUGCGGUAUUUCUUC 11111
ccGAcuGcGGuAuuucuucdTsdT sense 1855-1874 9112 GAAGAAAUACCGCAGUCGG
11112 GAAGAAAuACCGcAGUCGGdTsdT antis 1870-1889 9113
CUUCUACUCGAGUGGUGAG 11113 cuucuAcucGAGuGGuGAGdTsdT sense 1870-1889
9114 CUCACCACUCGAGUAGAAG 11114 CUcACcACUCGAGuAGAAGdTsdT antis
1895-1914 9115 GAUGAGGUCUACCUUAACC 11115 GAuGAGGucuAccuuAAccdTsdT
sense 1895-1914 9116 GGUUAAGGUAGACCUCAUC 11116
GGUuAAGGuAGACCUcAUCdTsdT antis 1916-1935 9117 GUGCUGGACUAUGUUCCGG
11117 GuGcuGGAcuAuGuuccGGdTsdT sense 1916-1935 9118
CCGGAACAUAGUCCAGCAC 11118 CCGGAAcAuAGUCcAGcACdTsdT antis 1927-1946
9119 UGUUCCGGAGACAGUGUAC 11119 uGuuccGGAGAcAGuGuAcdTsdT sense
1927-1946 9120 GUACACUGUCUCCGGAACA 11120 GuAcACUGUCUCCGGAAcAdTsdT
antis 1953-1972 9121 CCAGACACUAUAGUCGAGC 11121
ccAGAcAcuAuAGucGAGcdTsdT sense 1953-1972 9122 GCUCGACUAUAGUGUCUGG
11122 GCUCGACuAuAGUGUCUGGdTsdT antis 1959-1978 9123
ACUAUAGUCGAGCCAAGCA 11123 AcuAuAGucGAGccAAGcAdTsdT sense 1959-1978
9124 UGCUUGGCUCGACUAUAGU 11124 UGCUUGGCUCGACuAuAGUdTsdT antis
1960-1979 9125 CUAUAGUCGAGCCAAGCAG 11125 cuAuAGucGAGccAAGcAGdTsdT
sense 1960-1979 9126 CUGCUUGGCUCGACUAUAG 11126
CUGCUUGGCUCGACuAuAGdTsdT antis 2023-2042 9127 CAGAAGUCUAGCCUAUAUC
11127 cAGAAGucuAGccuAuAucdTsdT sense 2023-2042 9128
GAUAUAGGCUAGACUUCUG 11128 GAuAuAGGCuAGACUUCUGdTsdT antis 2089-2108
9129 GUUGGAUCCUGAUACAGCU 11129 GuuGGAuccuGAuAcAGcudTsdT sense
2089-2108 9130 AGCUGUAUCAGGAUCCAAC 11130 AGCUGuAUcAGGAUCcAACdTsdT
antis 2179-2198 9131 UUCUCGGUACUACAGGGCA 11131
uucucGGuAcuAcAGGGcAdTsdT sense 2179-2198 9132 UGCCCUGUAGUACCGAGAA
11132 UGCCCUGuAGuACCGAGAAdTsdT antis 2188-2207 9133
CUACAGGGCACCAGAGUUG 11133 cuAcAGGGcAccAGAGuuGdTsdT sense 2188-2207
9134 CAACUCUGGUGCCCUGUAG 11134 cAACUCUGGUGCCCUGuAGdTsdT antis
2218-2237 9135 CACUGAUUACACGUCCAGU 11135 cAcuGAuuAcAcGuccAGudTsdT
sense 2218-2237 9136 ACUGGACGUGUAAUCAGUG 11136
ACUGGACGUGuAAUcAGUGdTsdT antis 2219-2238 9137 ACUGAUUACACGUCCAGUA
11137 AcuGAuuAcAcGuccAGuAdTsdT sense 2219-2238 9138
UACUGGACGUGUAAUCAGU 11138 uACUGGACGUGuAAUcAGUdTsdT antis 2226-2245
9139 ACACGUCCAGUAUAGAUGU 11139 AcAcGuccAGuAuAGAuGudTsdT sense
2226-2245 9140 ACAUCUAUACUGGACGUGU 11140 AcAUCuAuACUGGACGUGUdTsdT
antis 2227-2246 9141 CACGUCCAGUAUAGAUGUA 11141
cAcGuccAGuAuAGAuGuAdTsdT sense 2227-2246 9142 UACAUCUAUACUGGACGUG
11142 uAcAUCuAuACUGGACGUGdTsdT antis 2276-2295 9143
UUGCUAGGACAACCAAUAU 11143 uuGcuAGGAcAAccAAuAudTsdT sense 2276-2295
9144 AUAUUGGUUGUCCUAGCAA 11144 AuAUUGGUUGUCCuAGcAAdTsdT antis
2277-2296 9145 UGCUAGGACAACCAAUAUU 11145 uGcuAGGAcAAccAAuAuudTsdT
sense 2277-2296 9146 AAUAUUGGUUGUCCUAGCA 11146
AAuAUUGGUUGUCCuAGcAdTsdT antis 2279-2298 9147 CUAGGACAACCAAUAUUUC
11147 cuAGGAcAAccAAuAuuucdTsdT sense 2279-2298 9148
GAAAUAUUGGUUGUCCUAG 11148 GAAAuAUUGGUUGUCCuAGdTsdT antis 2306-2325
9149 AGUGGUGUGGAUCAGUUGG 11149 AGuGGuGuGGAucAGuuGGdTsdT sense
2306-2325 9150 CCAACUGAUCCACACCACU 11150 CcAACUGAUCcAcACcACUdTsdT
antis 2488-2507 9151 GGAGUACACACCUACCGCC 11151
GGAGuAcAcAccuAccGccdTsdT sense 2488-2507 9152 GGCGGUAGGUGUGUACUCC
11152 GGCGGuAGGUGUGuACUCCdTsdT antis 2491-2510 9153
GUACACACCUACCGCCCGG 11153 GuAcAcAccuAccGcccGGdTsdT sense 2491-2510
9154 CCGGGCGGUAGGUGUGUAC 11154 CCGGGCGGuAGGUGUGuACdTsdT antis
2501-2520 9155 ACCGCCCGGCUAACACCAC 11155 AccGcccGGcuAAcAccAcdTsdT
sense 2501-2520 9156 GUGGUGUUAGCCGGGCGGU 11156
GUGGUGUuAGCCGGGCGGUdTsdT antis 2506-2525 9157 CCGGCUAACACCACUGGAA
11157 ccGGcuAAcAccAcuGGAAdTsdT sense 2506-2525 9158
UUCCAGUGGUGUUAGCCGG 11158 UUCcAGUGGUGUuAGCCGGdTsdT antis 1695-1714
9159 CAGACACGAAAGUGAUUGG 11159 cAGAcAcGAAAGuGAuuGGdTsdT sense
1695-1714 9160 CCAAUCACUUUCGUGUCUG 11160 CcAAUcACUUUCGUGUCUGdTsdT
antis 1720-1739 9161 AUCAUUUGGUGUGGUAUAU 11161
AucAuuuGGuGuGGuAuAudTsdT sense 1720-1739 9162 AUAUACCACACCAAAUGAU
11162 AuAuACcAcACcAAAUGAUdTsdT antis 1722-1741 9163
CAUUUGGUGUGGUAUAUCA 11163 cAuuuGGuGuGGuAuAucAdTsdT sense 1722-1741
9164 UGAUAUACCACACCAAAUG 11164 UGAuAuACcAcACcAAAUGdTsdT antis
1833-1852 9165 AGCUAGACCACUGUAACAU 11165 AGcuAGAccAcuGuAAcAudTsdT
sense 1833-1852 9166 AUGUUACAGUGGUCUAGCU 11166
AUGUuAcAGUGGUCuAGCUdTsdT antis 1848-1867 9167 ACAUAGUCCGACUGCGGUA
11167 AcAuAGuccGAcuGcGGuAdTsdT sense 1848-1867 9168
UACCGCAGUCGGACUAUGU 11168 uACCGcAGUCGGACuAUGUdTsdT antis 1872-1891
9169 UCUACUCGAGUGGUGAGAA 11169 ucuAcucGAGuGGuGAGAAdTsdT sense
1872-1891 9170 UUCUCACCACUCGAGUAGA 11170 UUCUcACcACUCGAGuAGAdTsdT
antis 1998-2017 9171 UCAAGUUGUAUAUGUAUCA 11171
ucAAGuuGuAuAuGuAucAdTsdT sense 1998-2017 9172 UGAUACAUAUACAACUUGA
11172 UGAuAcAuAuAcAACUUGAdTsdT antis 2011-2030 9173
GUAUCAGCUGUUCAGAAGU 11173 GuAucAGcuGuucAGAAGudTsdT sense 2011-2030
9174 ACUUCUGAACAGCUGAUAC 11174 ACUUCUGAAcAGCUGAuACdTsdT antis
2054-2073 9175 AUCUGCCAUCGAGACAUUA 11175 AucuGccAucGAGAcAuuAdTsdT
sense 2054-2073 9176 UAAUGUCUCGAUGGCAGAU 11176
uAAUGUCUCGAUGGcAGAUdTsdT antis 2153-2172 9177 GGAGAGCCCAAUGUUUCAU
11177 GGAGAGcccAAuGuuucAudTsdT sense 2153-2172 9178
AUGAAACAUUGGGCUCUCC 11178 AUGAAAcAUUGGGCUCUCCdTsdT antis 2168-2187
9179 UCAUAUAUCUGUUCUCGGU 11179 ucAuAuAucuGuucucGGudTsdT sense
2168-2187 9180 ACCGAGAACAGAUAUAUGA 11180 ACCGAGAAcAGAuAuAUGAdTsdT
antis 2181-2200 9181 CUCGGUACUACAGGGCACC 11181
cucGGuAcuAcAGGGcAccdTsdT sense 2181-2200 9182 GGUGCCCUGUAGUACCGAG
11182 GGUGCCCUGuAGuACCGAGdTsdT antis 2305-2324 9183
CAGUGGUGUGGAUCAGUUG 11183 cAGuGGuGuGGAucAGuuGdTsdT sense 2305-2324
9184 CAACUGAUCCACACCACUG 11184 cAACUGAUCcAcACcACUGdTsdT antis
2354-2373 9185 ACAAGGGAGCAAAUUAGAG 11185 AcAAGGGAGcAAAuuAGAGdTsdT
sense 2354-2373 9186 CUCUAAUUUGCUCCCUUGU 11186
CUCuAAUUUGCUCCCUUGUdTsdT antis 2427-2446 9187 GGACAAAGGUCUUCCGGCC
11187 GGAcAAAGGucuuccGGccdTsdT sense 2427-2446 9188
GGCCGGAAGACCUUUGUCC 11188 GGCCGGAAGACCUUUGUCCdTsdT antis 1529-1548
9189 UCGGGGCGACCGAGAACCA 11189 ucGGGGcGAccGAGAAccAdTsdT sense
1529-1548 9190 UGGUUCUCGGUCGCCCCGA 11190 UGGUUCUCGGUCGCCCCGAdTsdT
antis 1532-1551 9191 GGGCGACCGAGAACCACCU 11191
GGGcGAccGAGAAccAccudTsdT sense 1532-1551 9192 AGGUGGUUCUCGGUCGCCC
11192 AGGUGGUUCUCGGUCGCCCdTsdT antis 1541-1560 9193
AGAACCACCUCCUUUGCGG 11193 AGAAccAccuccuuuGcGGdTsdT sense 1541-1560
9194 CCGCAAAGGAGGUGGUUCU 11194 CCGcAAAGGAGGUGGUUCUdTsdT antis
1591-1610 9195 UUUUGGUAGCAUGAAAGUU 11195 uuuuGGuAGcAuGAAAGuudTsdT
sense 1591-1610 9196 AACUUUCAUGCUACCAAAA 11196
AACUUUcAUGCuACcAAAAdTsdT antis 1677-1696 9197 CACAGGAAGUCAGUUAUAC
11197 cAcAGGAAGucAGuuAuAcdTsdT sense 1677-1696 9198
GUAUAACUGACUUCCUGUG 11198 GuAuAACUGACUUCCUGUGdTsdT antis 1679-1698
9199 CAGGAAGUCAGUUAUACAG 11199 cAGGAAGucAGuuAuAcAGdTsdT sense
1679-1698 9200 CUGUAUAACUGACUUCCUG 11200 CUGuAuAACUGACUUCCUGdTsdT
antis 1680-1699 9201 AGGAAGUCAGUUAUACAGA 11201
AGGAAGucAGuuAuAcAGAdTsdT sense 1680-1699 9202 UCUGUAUAACUGACUUCCU
11202 UCUGuAuAACUGACUUCCUdTsdT antis 1681-1700 9203
GGAAGUCAGUUAUACAGAC 11203 GGAAGucAGuuAuAcAGAcdTsdT sense 1681-1700
9204 GUCUGUAUAACUGACUUCC 11204 GUCUGuAuAACUGACUUCCdTsdT antis
1705-1724 9205 AGUGAUUGGAAAUGGAUCA 11205 AGuGAuuGGAAAuGGAucAdTsdT
sense 1705-1724 9206 UGAUCCAUUUCCAAUCACU 11206
UGAUCcAUUUCcAAUcACUdTsdT antis 1706-1725 9207 GUGAUUGGAAAUGGAUCAU
11207 GuGAuuGGAAAuGGAucAudTsdT sense 1706-1725 9208
AUGAUCCAUUUCCAAUCAC 11208 AUGAUCcAUUUCcAAUcACdTsdT antis 1708-1727
9209 GAUUGGAAAUGGAUCAUUU 11209 GAuuGGAAAuGGAucAuuudTsdT sense
1708-1727 9210 AAAUGAUCCAUUUCCAAUC 11210 AAAUGAUCcAUUUCcAAUCdTsdT
antis 1724-1743 9211 UUUGGUGUGGUAUAUCAAG 11211
uuuGGuGuGGuAuAucAAGdTsdT sense 1724-1743 9212 CUUGAUAUACCACACCAAA
11212 CUUGAuAuACcAcACcAAAdTsdT antis 1725-1744 9213
UUGGUGUGGUAUAUCAAGC 11213 uuGGuGuGGuAuAucAAGcdTsdT sense 1725-1744
9214 GCUUGAUAUACCACACCAA 11214 GCUUGAuAuACcAcACcAAdTsdT antis
1727-1746 9215 GGUGUGGUAUAUCAAGCCA 11215 GGuGuGGuAuAucAAGccAdTsdT
sense 1727-1746 9216 UGGCUUGAUAUACCACACC 11216
UGGCUUGAuAuACcAcACCdTsdT antis 1739-1758 9217 CAAGCCAAACUUUGUGAUU
11217 cAAGccAAAcuuuGuGAuudTsdT sense 1739-1758 9218
AAUCACAAAGUUUGGCUUG 11218 AAUcAcAAAGUUUGGCUUGdTsdT antis 1785-1804
9219 UUCUACAGGACAAGCGAUU 11219 uucuAcAGGAcAAGcGAuudTsdT sense
1785-1804 9220 AAUCGCUUGUCCUGUAGAA 11220 AAUCGCUUGUCCUGuAGAAdTsdT
antis 1828-1847 9221 GAGAAAGCUAGACCACUGU 11221
GAGAAAGcuAGAccAcuGudTsdT sense 1828-1847 9222 ACAGUGGUCUAGCUUUCUC
11222 AcAGUGGUCuAGCUUUCUCdTsdT antis 1829-1848 9223
AGAAAGCUAGACCACUGUA 11223 AGAAAGcuAGAccAcuGuAdTsdT sense 1829-1848
9224 UACAGUGGUCUAGCUUUCU 11224 uAcAGUGGUCuAGCUUUCUdTsdT antis
1837-1856 9225 AGACCACUGUAACAUAGUC 11225 AGAccAcuGuAAcAuAGucdTsdT
sense 1837-1856 9226 GACUAUGUUACAGUGGUCU 11226
GACuAUGUuAcAGUGGUCUdTsdT antis 1839-1858 9227 ACCACUGUAACAUAGUCCG
11227 AccAcuGuAAcAuAGuccGdTsdT sense 1839-1858 9228
CGGACUAUGUUACAGUGGU 11228 CGGACuAUGUuAcAGUGGUdTsdT antis 1841-1860
9229 CACUGUAACAUAGUCCGAC 11229 cAcuGuAAcAuAGuccGAcdTsdT sense
1841-1860 9230 GUCGGACUAUGUUACAGUG 11230 GUCGGACuAUGUuAcAGUGdTsdT
antis 1864-1883 9231 GUAUUUCUUCUACUCGAGU 11231
GuAuuucuucuAcucGAGudTsdT sense 1864-1883 9232 ACUCGAGUAGAAGAAAUAC
11232 ACUCGAGuAGAAGAAAuACdTsdT antis 1865-1884 9233
UAUUUCUUCUACUCGAGUG 11233 uAuuucuucuAcucGAGuGdTsdT sense 1865-1884
9234 CACUCGAGUAGAAGAAAUA 11234 cACUCGAGuAGAAGAAAuAdTsdT antis
1867-1886 9235 UUUCUUCUACUCGAGUGGU 11235 uuucuucuAcucGAGuGGudTsdT
sense 1867-1886 9236 ACCACUCGAGUAGAAGAAA 11236
ACcACUCGAGuAGAAGAAAdTsdT antis 1874-1893 9237 UACUCGAGUGGUGAGAAGA
11237 uAcucGAGuGGuGAGAAGAdTsdT sense 1874-1893 9238
UCUUCUCACCACUCGAGUA 11238 UCUUCUcACcACUCGAGuAdTsdT antis 1894-1913
9239 AGAUGAGGUCUACCUUAAC 11239 AGAuGAGGucuAccuuAAcdTsdT sense
1894-1913 9240 GUUAAGGUAGACCUCAUCU 11240 GUuAAGGuAGACCUcAUCUdTsdT
antis 1921-1940 9241 GGACUAUGUUCCGGAGACA 11241
GGAcuAuGuuccGGAGAcAdTsdT sense 1921-1940 9242 UGUCUCCGGAACAUAGUCC
11242 UGUCUCCGGAAcAuAGUCCdTsdT antis 1954-1973 9243
CAGACACUAUAGUCGAGCC 11243 cAGAcAcuAuAGucGAGccdTsdT sense 1954-1973
9244 GGCUCGACUAUAGUGUCUG 11244 GGCUCGACuAuAGUGUCUGdTsdT antis
2006-2025 9245 UAUAUGUAUCAGCUGUUCA 11245 uAuAuGuAucAGcuGuucAdTsdT
sense 2006-2025 9246 UGAACAGCUGAUACAUAUA 11246
UGAAcAGCUGAuAcAuAuAdTsdT antis 2017-2036 9247 GCUGUUCAGAAGUCUAGCC
11247 GcuGuucAGAAGucuAGccdTsdT sense 2017-2036 9248
GGCUAGACUUCUGAACAGC 11248 GGCuAGACUUCUGAAcAGCdTsdT antis 2019-2038
9249 UGUUCAGAAGUCUAGCCUA 11249 uGuucAGAAGucuAGccuAdTsdT sense
2019-2038 9250 UAGGCUAGACUUCUGAACA 11250 uAGGCuAGACUUCUGAAcAdTsdT
antis 2026-2045 9251 AAGUCUAGCCUAUAUCCAU 11251
AAGucuAGccuAuAuccAudTsdT sense 2026-2045 9252 AUGGAUAUAGGCUAGACUU
11252 AUGGAuAuAGGCuAGACUUdTsdT antis 2052-2071 9253
GAAUCUGCCAUCGAGACAU 11253 GAAucuGccAucGAGAcAudTsdT sense 2052-2071
9254 AUGUCUCGAUGGCAGAUUC 11254 AUGUCUCGAUGGcAGAUUCdTsdT antis
2072-2091 9255 AAACCACAGAACCUCUUGU 11255 AAAccAcAGAAccucuuGudTsdT
sense 2072-2091 9256 ACAAGAGGUUCUGUGGUUU 11256
AcAAGAGGUUCUGUGGUUUdTsdT antis 2082-2101 9257 ACCUCUUGUUGGAUCCUGA
11257 AccucuuGuuGGAuccuGAdTsdT sense 2082-2101 9258
UCAGGAUCCAACAAGAGGU 11258 UcAGGAUCcAAcAAGAGGUdTsdT antis 2088-2107
9259 UGUUGGAUCCUGAUACAGC 11259 uGuuGGAuccuGAuAcAGcdTsdT sense
2088-2107 9260 GCUGUAUCAGGAUCCAACA 11260 GCUGuAUcAGGAUCcAAcAdTsdT
antis 2096-2115 9261 CCUGAUACAGCUGUAUUAA 11261
ccuGAuAcAGcuGuAuuAAdTsdT sense 2096-2115 9262 UUAAUACAGCUGUAUCAGG
11262 UuAAuAcAGCUGuAUcAGGdTsdT antis 2167-2186 9263
UUCAUAUAUCUGUUCUCGG 11263 uucAuAuAucuGuucucGGdTsdT sense 2167-2186
9264 CCGAGAACAGAUAUAUGAA 11264 CCGAGAAcAGAuAuAUGAAdTsdT antis
2192-2211 9265 AGGGCACCAGAGUUGAUCU 11265 AGGGcAccAGAGuuGAucudTsdT
sense 2192-2211 9266 AGAUCAACUCUGGUGCCCU 11266
AGAUcAACUCUGGUGCCCUdTsdT antis 2213-2232 9267 GGAGCCACUGAUUACACGU
11267 GGAGccAcuGAuuAcAcGudTsdT sense 2213-2232 9268
ACGUGUAAUCAGUGGCUCC 11268 ACGUGuAAUcAGUGGCUCCdTsdT antis 2214-2233
9269 GAGCCACUGAUUACACGUC 11269 GAGccAcuGAuuAcAcGucdTsdT sense
2214-2233 9270 GACGUGUAAUCAGUGGCUC 11270 GACGUGuAAUcAGUGGCUCdTsdT
antis 2225-2244 9271 UACACGUCCAGUAUAGAUG 11271
uAcAcGuccAGuAuAGAuGdTsdT sense 2225-2244 9272 CAUCUAUACUGGACGUGUA
11272 cAUCuAuACUGGACGUGuAdTsdT antis 2229-2248 9273
CGUCCAGUAUAGAUGUAUG 11273 cGuccAGuAuAGAuGuAuGdTsdT sense 2229-2248
9274 CAUACAUCUAUACUGGACG 11274 cAuAcAUCuAuACUGGACGdTsdT antis
2230-2249 9275 GUCCAGUAUAGAUGUAUGG 11275 GuccAGuAuAGAuGuAuGGdTsdT
sense 2230-2249 9276 CCAUACAUCUAUACUGGAC 11276
CcAuAcAUCuAuACUGGACdTsdT antis 2233-2252 9277 CAGUAUAGAUGUAUGGUCU
11277 cAGuAuAGAuGuAuGGucudTsdT sense 2233-2252 9278
AGACCAUACAUCUAUACUG 11278 AGACcAuAcAUCuAuACUGdTsdT antis 2236-2255
9279 UAUAGAUGUAUGGUCUGCA 11279 uAuAGAuGuAuGGucuGcAdTsdT sense
2236-2255 9280 UGCAGACCAUACAUCUAUA 11280 UGcAGACcAuAcAUCuAuAdTsdT
antis 2239-2258 9281 AGAUGUAUGGUCUGCAGGC 11281
AGAuGuAuGGucuGcAGGcdTsdT sense 2239-2258 9282 GCCUGCAGACCAUACAUCU
11282 GCCUGcAGACcAuAcAUCUdTsdT antis 2268-2287 9283
CUGAAUUGUUGCUAGGACA 11283 cuGAAuuGuuGcuAGGAcAdTsdT sense 2268-2287
9284 UGUCCUAGCAACAAUUCAG 11284 UGUCCuAGcAAcAAUUcAGdTsdT antis
2278-2297 9285 GCUAGGACAACCAAUAUUU 11285 GcuAGGAcAAccAAuAuuudTsdT
sense 2278-2297 9286 AAAUAUUGGUUGUCCUAGC 11286
AAAuAUUGGUUGUCCuAGCdTsdT antis 2286-2305 9287 AACCAAUAUUUCCUGGGGA
11287 AAccAAuAuuuccuGGGGAdTsdT sense 2286-2305 9288
UCCCCAGGAAAUAUUGGUU 11288 UCCCcAGGAAAuAUUGGUUdTsdT antis 2339-2358
9289 GUCCUAGGAACACCAACAA 11289 GuccuAGGAAcAccAAcAAdTsdT sense
2339-2358 9290 UUGUUGGUGUUCCUAGGAC 11290 UUGUUGGUGUUCCuAGGACdTsdT
antis 2340-2359 9291 UCCUAGGAACACCAACAAG 11291
uccuAGGAAcAccAAcAAGdTsdT sense 2340-2359 9292 CUUGUUGGUGUUCCUAGGA
11292 CUUGUUGGUGUUCCuAGGAdTsdT antis 2342-2361 9293
CUAGGAACACCAACAAGGG 11293 cuAGGAAcAccAAcAAGGGdTsdT sense 2342-2361
9294 CCCUUGUUGGUGUUCCUAG 11294 CCCUUGUUGGUGUUCCuAGdTsdT antis
2344-2363 9295 AGGAACACCAACAAGGGAG 11295 AGGAAcAccAAcAAGGGAGdTsdT
sense 2344-2363 9296 CUCCCUUGUUGGUGUUCCU 11296
CUCCCUUGUUGGUGUUCCUdTsdT antis 2355-2374 9297 CAAGGGAGCAAAUUAGAGA
11297 cAAGGGAGcAAAuuAGAGAdTsdT sense 2355-2374 9298
UCUCUAAUUUGCUCCCUUG 11298 UCUCuAAUUUGCUCCCUUGdTsdT antis 2397-2416
9299 UCAAAUUCCCUCAAAUCAA 11299 ucAAAuucccucAAAucAAdTsdT sense
2397-2416 9300 UUGAUUUGAGGGAAUUUGA 11300 UUGAUUUGAGGGAAUUUGAdTsdT
antis 2434-2453 9301 GGUCUUCCGGCCCCGAACU 11301
GGucuuccGGccccGAAcudTsdT sense 2434-2453 9302 AGUUCGGGGCCGGAAGACC
11302 AGUUCGGGGCCGGAAGACCdTsdT antis 2435-2454 9303
GUCUUCCGGCCCCGAACUC 11303 GucuuccGGccccGAAcucdTsdT sense 2435-2454
9304 GAGUUCGGGGCCGGAAGAC 11304 GAGUUCGGGGCCGGAAGACdTsdT antis
2437-2456 9305 CUUCCGGCCCCGAACUCCA 11305 cuuccGGccccGAAcuccAdTsdT
sense 2437-2456 9306 UGGAGUUCGGGGCCGGAAG 11306
UGGAGUUCGGGGCCGGAAGdTsdT antis 2453-2472 9307 CCACCAGAGGCAAUUGCAC
11307 ccAccAGAGGcAAuuGcAcdTsdT sense 2453-2472 9308
GUGCAAUUGCCUCUGGUGG 11308 GUGcAAUUGCCUCUGGUGGdTsdT antis 2467-2486
9309 UGCACUGUGCAGCCGUCUG 11309 uGcAcuGuGcAGccGucuGdTsdT sense
2467-2486 9310 CAGACGGCUGCACAGUGCA 11310 cAGACGGCUGcAcAGUGcAdTsdT
antis 2486-2505 9311 CUGGAGUACACACCUACCG 11311
cuGGAGuAcAcAccuAccGdTsdT sense 2486-2505 9312 CGGUAGGUGUGUACUCCAG
11312 CGGuAGGUGUGuACUCcAGdTsdT antis 2490-2509 9313
AGUACACACCUACCGCCCG 11313 AGuAcAcAccuAccGcccGdTsdT sense 2490-2509
9314 CGGGCGGUAGGUGUGUACU 11314 CGGGCGGuAGGUGUGuACUdTsdT antis
2505-2524 9315 CCCGGCUAACACCACUGGA 11315 cccGGcuAAcAccAcuGGAdTsdT
sense 2505-2524 9316 UCCAGUGGUGUUAGCCGGG 11316
UCcAGUGGUGUuAGCCGGGdTsdT antis 2508-2527 9317 GGCUAACACCACUGGAAGC
11317 GGcuAAcAccAcuGGAAGcdTsdT sense 2508-2527 9318
GCUUCCAGUGGUGUUAGCC 11318 GCUUCcAGUGGUGUuAGCCdTsdT antis 1938-1957
9319 CAGUGUACAGAGUCGCCAG 11319 cAGuGuAcAGAGucGccAGdTsdT sense
1938-1957 9320 CUGGCGACUCUGUACACUG 11320 CUGGCGACUCUGuAcACUGdTsdT
antis 1985-2004 9321 CCUGUGAUCUAUGUCAAGU 11321
ccuGuGAucuAuGucAAGudTsdT sense 1985-2004 9322 ACUUGACAUAGAUCACAGG
11322 ACUUGAcAuAGAUcAcAGGdTsdT antis 2164-2183 9323
UGUUUCAUAUAUCUGUUCU 11323 uGuuucAuAuAucuGuucudTsdT sense 2164-2183
9324 AGAACAGAUAUAUGAAACA 11324 AGAAcAGAuAuAUGAAAcAdTsdT antis
2263-2282 9325 GUUGGCUGAAUUGUUGCUA 11325 GuuGGcuGAAuuGuuGcuAdTsdT
sense 2263-2282 9326 UAGCAACAAUUCAGCCAAC 11326
uAGcAAcAAUUcAGCcAACdTsdT antis 2367-2386 9327 UUAGAGAAAUGAACCCAAA
11327 uuAGAGAAAuGAAcccAAAdTsdT sense 2367-2386 9328
UUUGGGUUCAUUUCUCUAA 11328 UUUGGGUUcAUUUCUCuAAdTsdT antis 2395-2414
9329 AUUCAAAUUCCCUCAAAUC 11329 AuucAAAuucccucAAAucdTsdT sense
2395-2414 9330 GAUUUGAGGGAAUUUGAAU 11330 GAUUUGAGGGAAUUUGAAUdTsdT
antis 1624-1643 9331 UGGCAGCAAGGUAACCACA 11331
uGGcAGcAAGGuAAccAcAdTsdT sense 1624-1643 9332 UGUGGUUACCUUGCUGCCA
11332 UGUGGUuACCUUGCUGCcAdTsdT antis 1686-1705 9333
UCAGUUAUACAGACACGAA 11333 ucAGuuAuAcAGAcAcGAAdTsdT sense 1686-1705
9334 UUCGUGUCUGUAUAACUGA 11334 UUCGUGUCUGuAuAACUGAdTsdT antis
1979-1998 9335 ACACUCCCUGUGAUCUAUG 11335 AcAcucccuGuGAucuAuGdTsdT
sense 1979-1998 9336 CAUAGAUCACAGGGAGUGU 11336
cAuAGAUcAcAGGGAGUGUdTsdT antis 2080-2099 9337 GAACCUCUUGUUGGAUCCU
11337 GAAccucuuGuuGGAuccudTsdT sense 2080-2099 9338
AGGAUCCAACAAGAGGUUC 11338 AGGAUCcAAcAAGAGGUUCdTsdT antis 2091-2110
9339 UGGAUCCUGAUACAGCUGU 11339 uGGAuccuGAuAcAGcuGudTsdT sense
2091-2110 9340 ACAGCUGUAUCAGGAUCCA 11340 AcAGCUGuAUcAGGAUCcAdTsdT
antis 2162-2181 9341 AAUGUUUCAUAUAUCUGUU 11341
AAuGuuucAuAuAucuGuudTsdT sense 2162-2181 9342 AACAGAUAUAUGAAACAUU
11342 AAcAGAuAuAUGAAAcAUUdTsdT antis 2175-2194 9343
UCUGUUCUCGGUACUACAG 11343 ucuGuucucGGuAcuAcAGdTsdT sense 2175-2194
9344 CUGUAGUACCGAGAACAGA 11344 CUGuAGuACCGAGAAcAGAdTsdT antis
2267-2286 9345 GCUGAAUUGUUGCUAGGAC 11345 GcuGAAuuGuuGcuAGGAcdTsdT
sense 2267-2286 9346 GUCCUAGCAACAAUUCAGC 11346
GUCCuAGcAAcAAUUcAGCdTsdT antis 2309-2328 9347 GGUGUGGAUCAGUUGGUGG
11347 GGuGuGGAucAGuuGGuGGdTsdT sense 2309-2328 9348
CCACCAACUGAUCCACACC 11348 CcACcAACUGAUCcAcACCdTsdT antis 2451-2470
9349 CUCCACCAGAGGCAAUUGC 11349 cuccAccAGAGGcAAuuGcdTsdT sense
2451-2470 9350 GCAAUUGCCUCUGGUGGAG 11350 GcAAUUGCCUCUGGUGGAGdTsdT
antis 1546-1565 9351 CACCUCCUUUGCGGAGAGC 11351
cAccuccuuuGcGGAGAGcdTsdT sense 1546-1565 9352 GCUCUCCGCAAAGGAGGUG
11352 GCUCUCCGcAAAGGAGGUGdTsdT antis 1936-1955 9353
GACAGUGUACAGAGUCGCC 11353 GAcAGuGuAcAGAGucGccdTsdT sense 1936-1955
9354 GGCGACUCUGUACACUGUC 11354 GGCGACUCUGuAcACUGUCdTsdT antis
1592-1611 9355 UUUGGUAGCAUGAAAGUUA 11355 uuuGGuAGcAuGAAAGuuAdTsdT
sense
1592-1611 9356 UAACUUUCAUGCUACCAAA 11356 uAACUUUcAUGCuACcAAAdTsdT
antis 1620-1639 9357 AAGAUGGCAGCAAGGUAAC 11357
AAGAuGGcAGcAAGGuAAcdTsdT sense 1620-1639 9358 GUUACCUUGCUGCCAUCUU
11358 GUuACCUUGCUGCcAUCUUdTsdT antis 1675-1694 9359
GCCACAGGAAGUCAGUUAU 11359 GccAcAGGAAGucAGuuAudTsdT sense 1675-1694
9360 AUAACUGACUUCCUGUGGC 11360 AuAACUGACUUCCUGUGGCdTsdT antis
1723-1742 9361 AUUUGGUGUGGUAUAUCAA 11361 AuuuGGuGuGGuAuAucAAdTsdT
sense 1723-1742 9362 UUGAUAUACCACACCAAAU 11362
UUGAuAuACcAcACcAAAUdTsdT antis 1738-1757 9363 UCAAGCCAAACUUUGUGAU
11363 ucAAGccAAAcuuuGuGAudTsdT sense 1738-1757 9364
AUCACAAAGUUUGGCUUGA 11364 AUcAcAAAGUUUGGCUUGAdTsdT antis 1758-1777
9365 CUGGAGAACUGGUUGCCAU 11365 cuGGAGAAcuGGuuGccAudTsdT sense
1758-1777 9366 AUGGCAACCAGUUCUCCAG 11366 AUGGcAACcAGUUCUCcAGdTsdT
antis 2027-2046 9367 AGUCUAGCCUAUAUCCAUU 11367
AGucuAGccuAuAuccAuudTsdT sense 2027-2046 9368 AAUGGAUAUAGGCUAGACU
11368 AAUGGAuAuAGGCuAGACUdTsdT antis 2083-2102 9369
CCUCUUGUUGGAUCCUGAU 11369 ccucuuGuuGGAuccuGAudTsdT sense 2083-2102
9370 AUCAGGAUCCAACAAGAGG 11370 AUcAGGAUCcAAcAAGAGGdTsdT antis
2097-2116 9371 CUGAUACAGCUGUAUUAAA 11371 cuGAuAcAGcuGuAuuAAAdTsdT
sense 2097-2116 9372 UUUAAUACAGCUGUAUCAG 11372
UUuAAuAcAGCUGuAUcAGdTsdT antis 2104-2123 9373 AGCUGUAUUAAAACUCUGU
11373 AGcuGuAuuAAAAcucuGudTsdT sense 2104-2123 9374
ACAGAGUUUUAAUACAGCU 11374 AcAGAGUUUuAAuAcAGCUdTsdT antis 2208-2227
9375 UCUUUGGAGCCACUGAUUA 11375 ucuuuGGAGccAcuGAuuAdTsdT sense
2208-2227 9376 UAAUCAGUGGCUCCAAAGA 11376 uAAUcAGUGGCUCcAAAGAdTsdT
antis 2210-2229 9377 UUUGGAGCCACUGAUUACA 11377
uuuGGAGccAcuGAuuAcAdTsdT sense 2210-2229 9378 UGUAAUCAGUGGCUCCAAA
11378 UGuAAUcAGUGGCUCcAAAdTsdT antis 2304-2323 9379
ACAGUGGUGUGGAUCAGUU 11379 AcAGuGGuGuGGAucAGuudTsdT sense 2304-2323
9380 AACUGAUCCACACCACUGU 11380 AACUGAUCcAcACcACUGUdTsdT antis
2328-2347 9381 AAAUAAUAAAGGUCCUAGG 11381 AAAuAAuAAAGGuccuAGGdTsdT
sense 2328-2347 9382 CCUAGGACCUUUAUUAUUU 11382
CCuAGGACCUUuAUuAUUUdTsdT antis 2390-2409 9383 ACAGAAUUCAAAUUCCCUC
11383 AcAGAAuucAAAuucccucdTsdT sense 2390-2409 9384
GAGGGAAUUUGAAUUCUGU 11384 GAGGGAAUUUGAAUUCUGUdTsdT antis 2018-2037
9385 CUGUUCAGAAGUCUAGCCU 11385 cuGuucAGAAGucuAGccudTsdT sense
2018-2037 9386 AGGCUAGACUUCUGAACAG 11386 AGGCuAGACUUCUGAAcAGdTsdT
antis 2338-2357 9387 GGUCCUAGGAACACCAACA 11387
GGuccuAGGAAcAccAAcAdTsdT sense 2338-2357 9388 UGUUGGUGUUCCUAGGACC
11388 UGUUGGUGUUCCuAGGACCdTsdT antis 2351-2370 9389
CCAACAAGGGAGCAAAUUA 11389 ccAAcAAGGGAGcAAAuuAdTsdT sense 2351-2370
9390 UAAUUUGCUCCCUUGUUGG 11390 uAAUUUGCUCCCUUGUUGGdTsdT antis
2433-2452 9391 AGGUCUUCCGGCCCCGAAC 11391 AGGucuuccGGccccGAAcdTsdT
sense 2433-2452 9392 GUUCGGGGCCGGAAGACCU 11392
GUUCGGGGCCGGAAGACCUdTsdT antis 2180-2199 9393 UCUCGGUACUACAGGGCAC
11393 ucucGGuAcuAcAGGGcAcdTsdT sense 2180-2199 9394
GUGCCCUGUAGUACCGAGA 11394 GUGCCCUGuAGuACCGAGAdTsdT antis 1644-1663
9395 UAGUGGCAACUCCUGGCCA 11395 uAGuGGcAAcuccuGGccAdTsdT sense
1644-1663 9396 UGGCCAGGAGUUGCCACUA 11396 UGGCcAGGAGUUGCcACuAdTsdT
antis 1827-1846 9397 UGAGAAAGCUAGACCACUG 11397
uGAGAAAGcuAGAccAcuGdTsdT sense 1827-1846 9398 CAGUGGUCUAGCUUUCUCA
11398 cAGUGGUCuAGCUUUCUcAdTsdT antis 2098-2117 9399
UGAUACAGCUGUAUUAAAA 11399 uGAuAcAGcuGuAuuAAAAdTsdT sense 2098-2117
9400 UUUUAAUACAGCUGUAUCA 11400 UUUuAAuAcAGCUGuAUcAdTsdT antis
2254-2273 9401 AGGCUGUGUGUUGGCUGAA 11401 AGGcuGuGuGuuGGcuGAAdTsdT
sense 2254-2273 9402 UUCAGCCAACACACAGCCU 11402
UUcAGCcAAcAcAcAGCCUdTsdT antis 1674-1693 9403 GGCCACAGGAAGUCAGUUA
11403 GGccAcAGGAAGucAGuuAdTsdT sense 1674-1693 9404
UAACUGACUUCCUGUGGCC 11404 uAACUGACUUCCUGUGGCCdTsdT antis 2495-2514
9405 ACACCUACCGCCCGGCUAA 11405 AcAccuAccGcccGGcuAAdTsdT sense
2495-2514 9406 UUAGCCGGGCGGUAGGUGU 11406 UuAGCCGGGCGGuAGGUGUdTsdT
antis 1794-1813 9407 ACAAGCGAUUUAAGAACCG 11407
AcAAGcGAuuuAAGAAccGdTsdT sense 1794-1813 9408 CGGUUCUUAAAUCGCUUGU
11408 CGGUUCUuAAAUCGCUUGUdTsdT antis 1861-1880 9409
GCGGUAUUUCUUCUACUCG 11409 GcGGuAuuucuucuAcucGdTsdT sense 1861-1880
9410 CGAGUAGAAGAAAUACCGC 11410 CGAGuAGAAGAAAuACCGCdTsdT antis
1989-2008 9411 UGAUCUAUGUCAAGUUGUA 11411 uGAucuAuGucAAGuuGuAdTsdT
sense 1989-2008 9412 UACAACUUGACAUAGAUCA 11412
uAcAACUUGAcAuAGAUcAdTsdT antis 2025-2044 9413 GAAGUCUAGCCUAUAUCCA
11413 GAAGucuAGccuAuAuccAdTsdT sense 2025-2044 9414
UGGAUAUAGGCUAGACUUC 11414 UGGAuAuAGGCuAGACUUCdTsdT antis 2028-2047
9415 GUCUAGCCUAUAUCCAUUC 11415 GucuAGccuAuAuccAuucdTsdT sense
2028-2047 9416 GAAUGGAUAUAGGCUAGAC 11416 GAAUGGAuAuAGGCuAGACdTsdT
antis 2029-2048 9417 UCUAGCCUAUAUCCAUUCC 11417
ucuAGccuAuAuccAuuccdTsdT sense 2029-2048 9418 GGAAUGGAUAUAGGCUAGA
11418 GGAAUGGAuAuAGGCuAGAdTsdT antis 2275-2294 9419
GUUGCUAGGACAACCAAUA 11419 GuuGcuAGGAcAAccAAuAdTsdT sense 2275-2294
9420 UAUUGGUUGUCCUAGCAAC 11420 uAUUGGUUGUCCuAGcAACdTsdT antis
1593-1612 9421 UUGGUAGCAUGAAAGUUAG 11421 uuGGuAGcAuGAAAGuuAGdTsdT
sense 1593-1612 9422 CUAACUUUCAUGCUACCAA 11422
CuAACUUUcAUGCuACcAAdTsdT antis 1690-1709 9423 UUAUACAGACACGAAAGUG
11423 uuAuAcAGAcAcGAAAGuGdTsdT sense 1690-1709 9424
CACUUUCGUGUCUGUAUAA 11424 cACUUUCGUGUCUGuAuAAdTsdT antis 1795-1814
9425 CAAGCGAUUUAAGAACCGA 11425 cAAGcGAuuuAAGAAccGAdTsdT sense
1795-1814 9426 UCGGUUCUUAAAUCGCUUG 11426 UCGGUUCUuAAAUCGCUUGdTsdT
antis 1822-1841 9427 GAUCAUGAGAAAGCUAGAC 11427
GAucAuGAGAAAGcuAGAcdTsdT sense 1822-1841 9428 GUCUAGCUUUCUCAUGAUC
11428 GUCuAGCUUUCUcAUGAUCdTsdT antis 1901-1920 9429
GUCUACCUUAACCUGGUGC 11429 GucuAccuuAAccuGGuGcdTsdT sense 1901-1920
9430 GCACCAGGUUAAGGUAGAC 11430 GcACcAGGUuAAGGuAGACdTsdT antis
1926-1945 9431 AUGUUCCGGAGACAGUGUA 11431 AuGuuccGGAGAcAGuGuAdTsdT
sense 1926-1945 9432 UACACUGUCUCCGGAACAU 11432
uAcACUGUCUCCGGAAcAUdTsdT antis 1947-1966 9433 GAGUCGCCAGACACUAUAG
11433 GAGucGccAGAcAcuAuAGdTsdT sense 1947-1966 9434
CUAUAGUGUCUGGCGACUC 11434 CuAuAGUGUCUGGCGACUCdTsdT antis 1949-1968
9435 GUCGCCAGACACUAUAGUC 11435 GucGccAGAcAcuAuAGucdTsdT sense
1949-1968 9436 GACUAUAGUGUCUGGCGAC 11436 GACuAuAGUGUCUGGCGACdTsdT
antis 1956-1975 9437 GACACUAUAGUCGAGCCAA 11437
GAcAcuAuAGucGAGccAAdTsdT sense 1956-1975 9438 UUGGCUCGACUAUAGUGUC
11438 UUGGCUCGACuAuAGUGUCdTsdT antis 1977-1996 9439
AGACACUCCCUGUGAUCUA 11439 AGAcAcucccuGuGAucuAdTsdT sense 1977-1996
9440 UAGAUCACAGGGAGUGUCU 11440 uAGAUcAcAGGGAGUGUCUdTsdT antis
1990-2009 9441 GAUCUAUGUCAAGUUGUAU 11441 GAucuAuGucAAGuuGuAudTsdT
sense 1990-2009 9442 AUACAACUUGACAUAGAUC 11442
AuAcAACUUGAcAuAGAUCdTsdT antis 2008-2027 9443 UAUGUAUCAGCUGUUCAGA
11443 uAuGuAucAGcuGuucAGAdTsdT sense 2008-2027 9444
UCUGAACAGCUGAUACAUA 11444 UCUGAAcAGCUGAuAcAuAdTsdT antis 2047-2066
9445 CUUUGGAAUCUGCCAUCGA 11445 cuuuGGAAucuGccAucGAdTsdT sense
2047-2066 9446 UCGAUGGCAGAUUCCAAAG 11446 UCGAUGGcAGAUUCcAAAGdTsdT
antis 2187-2206 9447 ACUACAGGGCACCAGAGUU 11447
AcuAcAGGGcAccAGAGuudTsdT sense 2187-2206 9448 AACUCUGGUGCCCUGUAGU
11448 AACUCUGGUGCCCUGuAGUdTsdT antis 2307-2326 9449
GUGGUGUGGAUCAGUUGGU 11449 GuGGuGuGGAucAGuuGGudTsdT sense 2307-2326
9450 ACCAACUGAUCCACACCAC 11450 ACcAACUGAUCcAcACcACdTsdT antis
2357-2376 9451 AGGGAGCAAAUUAGAGAAA 11451 AGGGAGcAAAuuAGAGAAAdTsdT
sense 2357-2376 9452 UUUCUCUAAUUUGCUCCCU 11452
UUUCUCuAAUUUGCUCCCUdTsdT antis 2405-2424 9453 CCUCAAAUCAAGGCACAUC
11453 ccucAAAucAAGGcAcAucdTsdT sense 2405-2424 9454
GAUGUGCCUUGAUUUGAGG 11454 GAUGUGCCUUGAUUUGAGGdTsdT antis 2483-2502
9455 CUGCUGGAGUACACACCUA 11455 cuGcuGGAGuAcAcAccuAdTsdT sense
2483-2502 9456 UAGGUGUGUACUCCAGCAG 11456 uAGGUGUGuACUCcAGcAGdTsdT
antis 1629-1648 9457 GCAAGGUAACCACAGUAGU 11457
GcAAGGuAAccAcAGuAGudTsdT sense 1629-1648 9458 ACUACUGUGGUUACCUUGC
11458 ACuACUGUGGUuACCUUGCdTsdT antis 1972-1991 9459
CAAGCAGACACUCCCUGUG 11459 cAAGcAGAcAcucccuGuGdTsdT sense 1972-1991
9460 CACAGGGAGUGUCUGCUUG 11460 cAcAGGGAGUGUCUGCUUGdTsdT antis
1622-1641 9461 GAUGGCAGCAAGGUAACCA 11461 GAuGGcAGcAAGGuAAccAdTsdT
sense 1622-1641 9462 UGGUUACCUUGCUGCCAUC 11462
UGGUuACCUUGCUGCcAUCdTsdT antis 1635-1654 9463 UAACCACAGUAGUGGCAAC
11463 uAAccAcAGuAGuGGcAAcdTsdT sense 1635-1654 9464
GUUGCCACUACUGUGGUUA 11464 GUUGCcACuACUGUGGUuAdTsdT antis 1790-1809
9465 CAGGACAAGCGAUUUAAGA 11465 cAGGAcAAGcGAuuuAAGAdTsdT sense
1790-1809 9466 UCUUAAAUCGCUUGUCCUG 11466 UCUuAAAUCGCUUGUCCUGdTsdT
antis 1818-1837 9467 UCCAGAUCAUGAGAAAGCU 11467
uccAGAucAuGAGAAAGcudTsdT sense 1818-1837 9468 AGCUUUCUCAUGAUCUGGA
11468 AGCUUUCUcAUGAUCUGGAdTsdT antis 1854-1873 9469
UCCGACUGCGGUAUUUCUU 11469 uccGAcuGcGGuAuuucuudTsdT sense 1854-1873
9470 AAGAAAUACCGCAGUCGGA 11470 AAGAAAuACCGcAGUCGGAdTsdT antis
1942-1961 9471 GUACAGAGUCGCCAGACAC 11471 GuAcAGAGucGccAGAcAcdTsdT
sense 1942-1961 9472 GUGUCUGGCGACUCUGUAC 11472
GUGUCUGGCGACUCUGuACdTsdT antis 1988-2007 9473 GUGAUCUAUGUCAAGUUGU
11473 GuGAucuAuGucAAGuuGudTsdT sense 1988-2007 9474
ACAACUUGACAUAGAUCAC 11474 AcAACUUGAcAuAGAUcACdTsdT antis 2055-2074
9475 UCUGCCAUCGAGACAUUAA 11475 ucuGccAucGAGAcAuuAAdTsdT sense
2055-2074 9476 UUAAUGUCUCGAUGGCAGA 11476 UuAAUGUCUCGAUGGcAGAdTsdT
antis 2217-2236 9477 CCACUGAUUACACGUCCAG 11477
ccAcuGAuuAcAcGuccAGdTsdT sense 2217-2236 9478 CUGGACGUGUAAUCAGUGG
11478 CUGGACGUGuAAUcAGUGGdTsdT antis 2235-2254 9479
GUAUAGAUGUAUGGUCUGC 11479 GuAuAGAuGuAuGGucuGcdTsdT sense 2235-2254
9480 GCAGACCAUACAUCUAUAC 11480 GcAGACcAuAcAUCuAuACdTsdT antis
2258-2277 9481 UGUGUGUUGGCUGAAUUGU 11481 uGuGuGuuGGcuGAAuuGudTsdT
sense 2258-2277 9482 ACAAUUCAGCCAACACACA 11482
AcAAUUcAGCcAAcAcAcAdTsdT antis 2269-2288 9483 UGAAUUGUUGCUAGGACAA
11483 uGAAuuGuuGcuAGGAcAAdTsdT sense 2269-2288 9484
UUGUCCUAGCAACAAUUCA 11484 UUGUCCuAGcAAcAAUUcAdTsdT antis 2404-2423
9485 CCCUCAAAUCAAGGCACAU 11485 cccucAAAucAAGGcAcAudTsdT sense
2404-2423 9486 AUGUGCCUUGAUUUGAGGG 11486 AUGUGCCUUGAUUUGAGGGdTsdT
antis 2423-2442 9487 CCUUGGACAAAGGUCUUCC 11487
ccuuGGAcAAAGGucuuccdTsdT sense 2423-2442 9488 GGAAGACCUUUGUCCAAGG
11488 GGAAGACCUUUGUCcAAGGdTsdT antis 2455-2474 9489
ACCAGAGGCAAUUGCACUG 11489 AccAGAGGcAAuuGcAcuGdTsdT sense 2455-2474
9490 CAGUGCAAUUGCCUCUGGU 11490 cAGUGcAAUUGCCUCUGGUdTsdT antis
1586-1605 9491 UCAGCUUUUGGUAGCAUGA 11491 ucAGcuuuuGGuAGcAuGAdTsdT
sense 1586-1605 9492 UCAUGCUACCAAAAGCUGA 11492
UcAUGCuACcAAAAGCUGAdTsdT antis 1601-1620 9493 AUGAAAGUUAGCAGAGAUA
11493 AuGAAAGuuAGcAGAGAuAdTsdT sense 1601-1620 9494
UAUCUCUGCUAACUUUCAU 11494 uAUCUCUGCuAACUUUcAUdTsdT antis 1621-1640
9495 AGAUGGCAGCAAGGUAACC 11495 AGAuGGcAGcAAGGuAAccdTsdT sense
1621-1640 9496 GGUUACCUUGCUGCCAUCU 11496 GGUuACCUUGCUGCcAUCUdTsdT
antis 1626-1645 9497 GCAGCAAGGUAACCACAGU 11497
GcAGcAAGGuAAccAcAGudTsdT sense 1626-1645 9498 ACUGUGGUUACCUUGCUGC
11498 ACUGUGGUuACCUUGCUGCdTsdT antis 1658-1677 9499
GGCCAGGGUCCUGACAGGC 11499 GGccAGGGuccuGAcAGGcdTsdT sense 1658-1677
9500 GCCUGUCAGGACCCUGGCC 11500 GCCUGUcAGGACCCUGGCCdTsdT antis
1683-1702 9501 AAGUCAGUUAUACAGACAC 11501 AAGucAGuuAuAcAGAcAcdTsdT
sense 1683-1702 9502 GUGUCUGUAUAACUGACUU 11502
GUGUCUGuAuAACUGACUUdTsdT antis 1709-1728 9503 AUUGGAAAUGGAUCAUUUG
11503 AuuGGAAAuGGAucAuuuGdTsdT sense 1709-1728 9504
CAAAUGAUCCAUUUCCAAU 11504 cAAAUGAUCcAUUUCcAAUdTsdT antis 1710-1729
9505 UUGGAAAUGGAUCAUUUGG 11505 uuGGAAAuGGAucAuuuGGdTsdT sense
1710-1729 9506 CCAAAUGAUCCAUUUCCAA 11506 CcAAAUGAUCcAUUUCcAAdTsdT
antis 1726-1745 9507 UGGUGUGGUAUAUCAAGCC 11507
uGGuGuGGuAuAucAAGccdTsdT sense 1726-1745 9508 GGCUUGAUAUACCACACCA
11508 GGCUUGAuAuACcAcACcAdTsdT antis 1740-1759 9509
AAGCCAAACUUUGUGAUUC 11509 AAGccAAAcuuuGuGAuucdTsdT sense 1740-1759
9510 GAAUCACAAAGUUUGGCUU 11510 GAAUcAcAAAGUUUGGCUUdTsdT antis
1754-1773 9511 GAUUCUGGAGAACUGGUUG 11511 GAuucuGGAGAAcuGGuuGdTsdT
sense 1754-1773 9512 CAACCAGUUCUCCAGAAUC 11512
cAACcAGUUCUCcAGAAUCdTsdT antis 1755-1774 9513 AUUCUGGAGAACUGGUUGC
11513 AuucuGGAGAAcuGGuuGcdTsdT sense 1755-1774 9514
GCAACCAGUUCUCCAGAAU 11514 GcAACcAGUUCUCcAGAAUdTsdT antis 1757-1776
9515 UCUGGAGAACUGGUUGCCA 11515 ucuGGAGAAcuGGuuGccAdTsdT sense
1757-1776 9516 UGGCAACCAGUUCUCCAGA 11516 UGGcAACcAGUUCUCcAGAdTsdT
antis 1786-1805 9517 UCUACAGGACAAGCGAUUU 11517
ucuAcAGGAcAAGcGAuuudTsdT sense 1786-1805 9518 AAAUCGCUUGUCCUGUAGA
11518 AAAUCGCUUGUCCUGuAGAdTsdT antis 1834-1853 9519
GCUAGACCACUGUAACAUA 11519 GcuAGAccAcuGuAAcAuAdTsdT sense 1834-1853
9520 UAUGUUACAGUGGUCUAGC 11520 uAUGUuAcAGUGGUCuAGCdTsdT antis
1886-1905 9521 GAGAAGAAAGAUGAGGUCU 11521 GAGAAGAAAGAuGAGGucudTsdT
sense 1886-1905 9522 AGACCUCAUCUUUCUUCUC 11522
AGACCUcAUCUUUCUUCUCdTsdT antis 1887-1906 9523 AGAAGAAAGAUGAGGUCUA
11523 AGAAGAAAGAuGAGGucuAdTsdT sense 1887-1906 9524
UAGACCUCAUCUUUCUUCU 11524 uAGACCUcAUCUUUCUUCUdTsdT antis 1892-1911
9525 AAAGAUGAGGUCUACCUUA 11525 AAAGAuGAGGucuAccuuAdTsdT sense
1892-1911 9526 UAAGGUAGACCUCAUCUUU 11526 uAAGGuAGACCUcAUCUUUdTsdT
antis 1893-1912 9527 AAGAUGAGGUCUACCUUAA 11527
AAGAuGAGGucuAccuuAAdTsdT sense 1893-1912 9528 UUAAGGUAGACCUCAUCUU
11528 UuAAGGuAGACCUcAUCUUdTsdT antis 1925-1944 9529
UAUGUUCCGGAGACAGUGU 11529 uAuGuuccGGAGAcAGuGudTsdT sense 1925-1944
9530 ACACUGUCUCCGGAACAUA 11530 AcACUGUCUCCGGAAcAuAdTsdT antis
1937-1956 9531 ACAGUGUACAGAGUCGCCA 11531 AcAGuGuAcAGAGucGccAdTsdT
sense 1937-1956 9532 UGGCGACUCUGUACACUGU 11532
UGGCGACUCUGuAcACUGUdTsdT antis 1978-1997 9533 GACACUCCCUGUGAUCUAU
11533 GAcAcucccuGuGAucuAudTsdT sense 1978-1997 9534
AUAGAUCACAGGGAGUGUC 11534 AuAGAUcAcAGGGAGUGUCdTsdT antis 1980-1999
9535 CACUCCCUGUGAUCUAUGU 11535 cAcucccuGuGAucuAuGudTsdT sense
1980-1999 9536 ACAUAGAUCACAGGGAGUG 11536 AcAuAGAUcAcAGGGAGUGdTsdT
antis 2005-2024 9537 GUAUAUGUAUCAGCUGUUC 11537
GuAuAuGuAucAGcuGuucdTsdT sense 2005-2024 9538 GAACAGCUGAUACAUAUAC
11538 GAAcAGCUGAuAcAuAuACdTsdT antis 2074-2093 9539
ACCACAGAACCUCUUGUUG 11539 AccAcAGAAccucuuGuuGdTsdT sense 2074-2093
9540 CAACAAGAGGUUCUGUGGU 11540 cAAcAAGAGGUUCUGUGGUdTsdT antis
2081-2100 9541 AACCUCUUGUUGGAUCCUG 11541 AAccucuuGuuGGAuccuGdTsdT
sense 2081-2100 9542 CAGGAUCCAACAAGAGGUU 11542
cAGGAUCcAAcAAGAGGUUdTsdT antis 2094-2113 9543 AUCCUGAUACAGCUGUAUU
11543 AuccuGAuAcAGcuGuAuudTsdT sense 2094-2113 9544
AAUACAGCUGUAUCAGGAU 11544 AAuAcAGCUGuAUcAGGAUdTsdT antis 2101-2120
9545 UACAGCUGUAUUAAAACUC 11545 uAcAGcuGuAuuAAAAcucdTsdT sense
2101-2120 9546 GAGUUUUAAUACAGCUGUA 11546 GAGUUUuAAuAcAGCUGuAdTsdT
antis 2138-2157 9547 AAGCAGCUGGUCCGAGGAG 11547
AAGcAGcuGGuccGAGGAGdTsdT sense 2138-2157 9548 CUCCUCGGACCAGCUGCUU
11548 CUCCUCGGACcAGCUGCUUdTsdT antis 2161-2180 9549
CAAUGUUUCAUAUAUCUGU 11549 cAAuGuuucAuAuAucuGudTsdT sense 2161-2180
9550 ACAGAUAUAUGAAACAUUG 11550 AcAGAuAuAUGAAAcAUUGdTsdT antis
2171-2190 9551 UAUAUCUGUUCUCGGUACU 11551 uAuAucuGuucucGGuAcudTsdT
sense 2171-2190 9552 AGUACCGAGAACAGAUAUA 11552
AGuACCGAGAAcAGAuAuAdTsdT antis 2178-2197 9553 GUUCUCGGUACUACAGGGC
11553 GuucucGGuAcuAcAGGGcdTsdT sense 2178-2197 9554
GCCCUGUAGUACCGAGAAC 11554 GCCCUGuAGuACCGAGAACdTsdT antis 2193-2212
9555 GGGCACCAGAGUUGAUCUU 11555 GGGcAccAGAGuuGAucuudTsdT sense
2193-2212 9556 AAGAUCAACUCUGGUGCCC 11556 AAGAUcAACUCUGGUGCCCdTsdT
antis 2197-2216 9557 ACCAGAGUUGAUCUUUGGA 11557
AccAGAGuuGAucuuuGGAdTsdT sense 2197-2216 9558 UCCAAAGAUCAACUCUGGU
11558 UCcAAAGAUcAACUCUGGUdTsdT antis 2209-2228 9559
CUUUGGAGCCACUGAUUAC 11559 cuuuGGAGccAcuGAuuAcdTsdT sense 2209-2228
9560 GUAAUCAGUGGCUCCAAAG 11560 GuAAUcAGUGGCUCcAAAGdTsdT antis
2215-2234 9561 AGCCACUGAUUACACGUCC 11561 AGccAcuGAuuAcAcGuccdTsdT
sense 2215-2234 9562 GGACGUGUAAUCAGUGGCU 11562
GGACGUGuAAUcAGUGGCUdTsdT antis 2231-2250 9563 UCCAGUAUAGAUGUAUGGU
11563 uccAGuAuAGAuGuAuGGudTsdT sense 2231-2250 9564
ACCAUACAUCUAUACUGGA 11564 ACcAuAcAUCuAuACUGGAdTsdT antis 2308-2327
9565 UGGUGUGGAUCAGUUGGUG 11565 uGGuGuGGAucAGuuGGuGdTsdT sense
2308-2327 9566 CACCAACUGAUCCACACCA 11566 cACcAACUGAUCcAcACcAdTsdT
antis 2334-2353 9567 UAAAGGUCCUAGGAACACC 11567
uAAAGGuccuAGGAAcAccdTsdT sense 2334-2353 9568 GGUGUUCCUAGGACCUUUA
11568 GGUGUUCCuAGGACCUUuAdTsdT antis 2336-2355 9569
AAGGUCCUAGGAACACCAA 11569 AAGGuccuAGGAAcAccAAdTsdT sense 2336-2355
9570 UUGGUGUUCCUAGGACCUU 11570 UUGGUGUUCCuAGGACCUUdTsdT antis
2337-2356 9571 AGGUCCUAGGAACACCAAC 11571 AGGuccuAGGAAcAccAAcdTsdT
sense 2337-2356 9572 GUUGGUGUUCCUAGGACCU 11572
GUUGGUGUUCCuAGGACCUdTsdT antis 2343-2362 9573 UAGGAACACCAACAAGGGA
11573 uAGGAAcAccAAcAAGGGAdTsdT sense 2343-2362 9574
UCCCUUGUUGGUGUUCCUA 11574 UCCCUUGUUGGUGUUCCuAdTsdT antis 2352-2371
9575 CAACAAGGGAGCAAAUUAG 11575 cAAcAAGGGAGcAAAuuAGdTsdT sense
2352-2371 9576 CUAAUUUGCUCCCUUGUUG 11576 CuAAUUUGCUCCCUUGUUGdTsdT
antis 2370-2389 9577 GAGAAAUGAACCCAAAUUA 11577
GAGAAAuGAAcccAAAuuAdTsdT sense 2370-2389 9578 UAAUUUGGGUUCAUUUCUC
11578 uAAUUUGGGUUcAUUUCUCdTsdT antis 2385-2404 9579
AUUAUACAGAAUUCAAAUU 11579 AuuAuAcAGAAuucAAAuudTsdT sense 2385-2404
9580 AAUUUGAAUUCUGUAUAAU 11580 AAUUUGAAUUCUGuAuAAUdTsdT antis
2392-2411 9581 AGAAUUCAAAUUCCCUCAA 11581 AGAAuucAAAuucccucAAdTsdT
sense 2392-2411 9582 UUGAGGGAAUUUGAAUUCU 11582
UUGAGGGAAUUUGAAUUCUdTsdT antis 2393-2412 9583 GAAUUCAAAUUCCCUCAAA
11583 GAAuucAAAuucccucAAAdTsdT sense 2393-2412 9584
UUUGAGGGAAUUUGAAUUC 11584 UUUGAGGGAAUUUGAAUUCdTsdT antis 2403-2422
9585 UCCCUCAAAUCAAGGCACA 11585 ucccucAAAucAAGGcAcAdTsdT sense
2403-2422 9586 UGUGCCUUGAUUUGAGGGA 11586 UGUGCCUUGAUUUGAGGGAdTsdT
antis 2421-2440 9587 AUCCUUGGACAAAGGUCUU 11587
AuccuuGGAcAAAGGucuudTsdT sense 2421-2440 9588 AAGACCUUUGUCCAAGGAU
11588 AAGACCUUUGUCcAAGGAUdTsdT antis 2424-2443 9589
CUUGGACAAAGGUCUUCCG 11589 cuuGGAcAAAGGucuuccGdTsdT sense 2424-2443
9590 CGGAAGACCUUUGUCCAAG 11590 CGGAAGACCUUUGUCcAAGdTsdT antis
2454-2473 9591 CACCAGAGGCAAUUGCACU 11591 cAccAGAGGcAAuuGcAcudTsdT
sense 2454-2473 9592 AGUGCAAUUGCCUCUGGUG 11592
AGUGcAAUUGCCUCUGGUGdTsdT antis 2468-2487 9593 GCACUGUGCAGCCGUCUGC
11593 GcAcuGuGcAGccGucuGcdTsdT sense 2468-2487 9594
GCAGACGGCUGCACAGUGC 11594 GcAGACGGCUGcAcAGUGCdTsdT antis 2469-2488
9595 CACUGUGCAGCCGUCUGCU 11595 cAcuGuGcAGccGucuGcudTsdT sense
2469-2488 9596 AGCAGACGGCUGCACAGUG 11596 AGcAGACGGCUGcAcAGUGdTsdT
antis 2516-2535 9597 CCACUGGAAGCUUGUGCAC 11597
ccAcuGGAAGcuuGuGcAcdTsdT sense 2516-2535 9598 GUGCACAAGCUUCCAGUGG
11598 GUGcAcAAGCUUCcAGUGGdTsdT antis 1559-1578 9599
GAGAGCUGCAAGCCAGUGC 11599 GAGAGcuGcAAGccAGuGcdTsdT sense 1559-1578
9600 GCACUGGCUUGCAGCUCUC 11600 GcACUGGCUUGcAGCUCUCdTsdT antis
1676-1695 9601 CCACAGGAAGUCAGUUAUA 11601 ccAcAGGAAGucAGuuAuAdTsdT
sense 1676-1695 9602 UAUAACUGACUUCCUGUGG 11602
uAuAACUGACUUCCUGUGGdTsdT antis 1896-1915 9603 AUGAGGUCUACCUUAACCU
11603 AuGAGGucuAccuuAAccudTsdT sense 1896-1915 9604
AGGUUAAGGUAGACCUCAU 11604 AGGUuAAGGuAGACCUcAUdTsdT antis 2262-2281
9605 UGUUGGCUGAAUUGUUGCU 11605 uGuuGGcuGAAuuGuuGcudTsdT sense
2262-2281 9606 AGCAACAAUUCAGCCAACA 11606 AGcAAcAAUUcAGCcAAcAdTsdT
antis
2270-2289 9607 GAAUUGUUGCUAGGACAAC 11607 GAAuuGuuGcuAGGAcAAcdTsdT
sense 2270-2289 9608 GUUGUCCUAGCAACAAUUC 11608
GUUGUCCuAGcAAcAAUUCdTsdT antis 1576-1595 9609 GCAGCAGCCUUCAGCUUUU
11609 GcAGcAGccuucAGcuuuudTsdT sense 1576-1595 9610
AAAAGCUGAAGGCUGCUGC 11610 AAAAGCUGAAGGCUGCUGCdTsdT antis 1577-1596
9611 CAGCAGCCUUCAGCUUUUG 11611 cAGcAGccuucAGcuuuuGdTsdT sense
1577-1596 9612 CAAAAGCUGAAGGCUGCUG 11612 cAAAAGCUGAAGGCUGCUGdTsdT
antis 1623-1642 9613 AUGGCAGCAAGGUAACCAC 11613
AuGGcAGcAAGGuAAccAcdTsdT sense 1623-1642 9614 GUGGUUACCUUGCUGCCAU
11614 GUGGUuACCUUGCUGCcAUdTsdT antis 1645-1664 9615
AGUGGCAACUCCUGGCCAG 11615 AGuGGcAAcuccuGGccAGdTsdT sense 1645-1664
9616 CUGGCCAGGAGUUGCCACU 11616 CUGGCcAGGAGUUGCcACUdTsdT antis
1742-1761 9617 GCCAAACUUUGUGAUUCUG 11617 GccAAAcuuuGuGAuucuGdTsdT
sense 1742-1761 9618 CAGAAUCACAAAGUUUGGC 11618
cAGAAUcAcAAAGUUUGGCdTsdT antis 1778-1797 9619 AAGAAAGUUCUACAGGACA
11619 AAGAAAGuucuAcAGGAcAdTsdT sense 1778-1797 9620
UGUCCUGUAGAACUUUCUU 11620 UGUCCUGuAGAACUUUCUUdTsdT antis 1920-1939
9621 UGGACUAUGUUCCGGAGAC 11621 uGGAcuAuGuuccGGAGAcdTsdT sense
1920-1939 9622 GUCUCCGGAACAUAGUCCA 11622 GUCUCCGGAAcAuAGUCcAdTsdT
antis 1973-1992 9623 AAGCAGACACUCCCUGUGA 11623
AAGcAGAcAcucccuGuGAdTsdT sense 1973-1992 9624 UCACAGGGAGUGUCUGCUU
11624 UcAcAGGGAGUGUCUGCUUdTsdT antis 1984-2003 9625
CCCUGUGAUCUAUGUCAAG 11625 cccuGuGAucuAuGucAAGdTsdT sense 1984-2003
9626 CUUGACAUAGAUCACAGGG 11626 CUUGAcAuAGAUcAcAGGGdTsdT antis
2085-2104 9627 UCUUGUUGGAUCCUGAUAC 11627 ucuuGuuGGAuccuGAuAcdTsdT
sense 2085-2104 9628 GUAUCAGGAUCCAACAAGA 11628
GuAUcAGGAUCcAAcAAGAdTsdT antis 2090-2109 9629 UUGGAUCCUGAUACAGCUG
11629 uuGGAuccuGAuAcAGcuGdTsdT sense 2090-2109 9630
CAGCUGUAUCAGGAUCCAA 11630 cAGCUGuAUcAGGAUCcAAdTsdT antis 2170-2189
9631 AUAUAUCUGUUCUCGGUAC 11631 AuAuAucuGuucucGGuAcdTsdT sense
2170-2189 9632 GUACCGAGAACAGAUAUAU 11632 GuACCGAGAAcAGAuAuAUdTsdT
antis 2200-2219 9633 AGAGUUGAUCUUUGGAGCC 11633
AGAGuuGAucuuuGGAGccdTsdT sense 2200-2219 9634 GGCUCCAAAGAUCAACUCU
11634 GGCUCcAAAGAUcAACUCUdTsdT antis 2253-2272 9635
CAGGCUGUGUGUUGGCUGA 11635 cAGGcuGuGuGuuGGcuGAdTsdT sense 2253-2272
9636 UCAGCCAACACACAGCCUG 11636 UcAGCcAAcAcAcAGCCUGdTsdT antis
2264-2283 9637 UUGGCUGAAUUGUUGCUAG 11637 uuGGcuGAAuuGuuGcuAGdTsdT
sense 2264-2283 9638 CUAGCAACAAUUCAGCCAA 11638
CuAGcAAcAAUUcAGCcAAdTsdT antis 2285-2304 9639 CAACCAAUAUUUCCUGGGG
11639 cAAccAAuAuuuccuGGGGdTsdT sense 2285-2304 9640
CCCCAGGAAAUAUUGGUUG 11640 CCCcAGGAAAuAUUGGUUGdTsdT antis 2315-2334
9641 GAUCAGUUGGUGGAAAUAA 11641 GAucAGuuGGuGGAAAuAAdTsdT sense
2315-2334 9642 UUAUUUCCACCAACUGAUC 11642 UuAUUUCcACcAACUGAUCdTsdT
antis 2452-2471 9643 UCCACCAGAGGCAAUUGCA 11643
uccAccAGAGGcAAuuGcAdTsdT sense 2452-2471 9644 UGCAAUUGCCUCUGGUGGA
11644 UGcAAUUGCCUCUGGUGGAdTsdT antis 2503-2522 9645
CGCCCGGCUAACACCACUG 11645 cGcccGGcuAAcAccAcuGdTsdT sense 2503-2522
9646 CAGUGGUGUUAGCCGGGCG 11646 cAGUGGUGUuAGCCGGGCGdTsdT antis
2504-2523 9647 GCCCGGCUAACACCACUGG 11647 GcccGGcuAAcAccAcuGGdTsdT
sense 2504-2523 9648 CCAGUGGUGUUAGCCGGGC 11648
CcAGUGGUGUuAGCCGGGCdTsdT antis 1961-1980 9649 UAUAGUCGAGCCAAGCAGA
11649 uAuAGucGAGccAAGcAGAdTsdT sense 1961-1980 9650
UCUGCUUGGCUCGACUAUA 11650 UCUGCUUGGCUCGACuAuAdTsdT antis 1699-1718
9651 CACGAAAGUGAUUGGAAAU 11651 cAcGAAAGuGAuuGGAAAudTsdT sense
1699-1718 9652 AUUUCCAAUCACUUUCGUG 11652 AUUUCcAAUcACUUUCGUGdTsdT
antis 1791-1810 9653 AGGACAAGCGAUUUAAGAA 11653
AGGAcAAGcGAuuuAAGAAdTsdT sense 1791-1810 9654 UUCUUAAAUCGCUUGUCCU
11654 UUCUuAAAUCGCUUGUCCUdTsdT antis 1534-1553 9655
GCGACCGAGAACCACCUCC 11655 GcGAccGAGAAccAccuccdTsdT sense 1534-1553
9656 GGAGGUGGUUCUCGGUCGC 11656 GGAGGUGGUUCUCGGUCGCdTsdT antis
1899-1918 9657 AGGUCUACCUUAACCUGGU 11657 AGGucuAccuuAAccuGGudTsdT
sense 1899-1918 9658 ACCAGGUUAAGGUAGACCU 11658
ACcAGGUuAAGGuAGACCUdTsdT antis 1931-1950 9659 CCGGAGACAGUGUACAGAG
11659 ccGGAGAcAGuGuAcAGAGdTsdT sense 1931-1950 9660
CUCUGUACACUGUCUCCGG 11660 CUCUGuAcACUGUCUCCGGdTsdT antis 1964-1983
9661 AGUCGAGCCAAGCAGACAC 11661 AGucGAGccAAGcAGAcAcdTsdT sense
1964-1983 9662 GUGUCUGCUUGGCUCGACU 11662 GUGUCUGCUUGGCUCGACUdTsdT
antis 2056-2075 9663 CUGCCAUCGAGACAUUAAA 11663
cuGccAucGAGAcAuuAAAdTsdT sense 2056-2075 9664 UUUAAUGUCUCGAUGGCAG
11664 UUuAAUGUCUCGAUGGcAGdTsdT antis 2155-2174 9665
AGAGCCCAAUGUUUCAUAU 11665 AGAGcccAAuGuuucAuAudTsdT sense 2155-2174
9666 AUAUGAAACAUUGGGCUCU 11666 AuAUGAAAcAUUGGGCUCUdTsdT antis
2182-2201 9667 UCGGUACUACAGGGCACCA 11667 ucGGuAcuAcAGGGcAccAdTsdT
sense 2182-2201 9668 UGGUGCCCUGUAGUACCGA 11668
UGGUGCCCUGuAGuACCGAdTsdT antis 2329-2348 9669 AAUAAUAAAGGUCCUAGGA
11669 AAuAAuAAAGGuccuAGGAdTsdT sense 2329-2348 9670
UCCUAGGACCUUUAUUAUU 11670 UCCuAGGACCUUuAUuAUUdTsdT antis 2360-2379
9671 GAGCAAAUUAGAGAAAUGA 11671 GAGcAAAuuAGAGAAAuGAdTsdT sense
2360-2379 9672 UCAUUUCUCUAAUUUGCUC 11672 UcAUUUCUCuAAUUUGCUCdTsdT
antis 2500-2519 9673 UACCGCCCGGCUAACACCA 11673
uAccGcccGGcuAAcAccAdTsdT sense 2500-2519 9674 UGGUGUUAGCCGGGCGGUA
11674 UGGUGUuAGCCGGGCGGuAdTsdT antis 1526-1545 9675
AUGUCGGGGCGACCGAGAA 11675 AuGucGGGGcGAccGAGAAdTsdT sense 1526-1545
9676 UUCUCGGUCGCCCCGACAU 11676 UUCUCGGUCGCCCCGAcAUdTsdT antis
1535-1554 9677 CGACCGAGAACCACCUCCU 11677 cGAccGAGAAccAccuccudTsdT
sense 1535-1554 9678 AGGAGGUGGUUCUCGGUCG 11678
AGGAGGUGGUUCUCGGUCGdTsdT antis 1553-1572 9679 UUUGCGGAGAGCUGCAAGC
11679 uuuGcGGAGAGcuGcAAGcdTsdT sense 1553-1572 9680
GCUUGCAGCUCUCCGCAAA 11680 GCUUGcAGCUCUCCGcAAAdTsdT antis 1628-1647
9681 AGCAAGGUAACCACAGUAG 11681 AGcAAGGuAAccAcAGuAGdTsdT sense
1628-1647 9682 CUACUGUGGUUACCUUGCU 11682 CuACUGUGGUuACCUUGCUdTsdT
antis 1633-1652 9683 GGUAACCACAGUAGUGGCA 11683
GGuAAccAcAGuAGuGGcAdTsdT sense 1633-1652 9684 UGCCACUACUGUGGUUACC
11684 UGCcACuACUGUGGUuACCdTsdT antis 1682-1701 9685
GAAGUCAGUUAUACAGACA 11685 GAAGucAGuuAuAcAGAcAdTsdT sense 1682-1701
9686 UGUCUGUAUAACUGACUUC 11686 UGUCUGuAuAACUGACUUCdTsdT antis
1684-1703 9687 AGUCAGUUAUACAGACACG 11687 AGucAGuuAuAcAGAcAcGdTsdT
sense 1684-1703 9688 CGUGUCUGUAUAACUGACU 11688
CGUGUCUGuAuAACUGACUdTsdT antis 1698-1717 9689 ACACGAAAGUGAUUGGAAA
11689 AcAcGAAAGuGAuuGGAAAdTsdT sense 1698-1717 9690
UUUCCAAUCACUUUCGUGU 11690 UUUCcAAUcACUUUCGUGUdTsdT antis 1700-1719
9691 ACGAAAGUGAUUGGAAAUG 11691 AcGAAAGuGAuuGGAAAuGdTsdT sense
1700-1719 9692 CAUUUCCAAUCACUUUCGU 11692 cAUUUCcAAUcACUUUCGUdTsdT
antis 1703-1722 9693 AAAGUGAUUGGAAAUGGAU 11693
AAAGuGAuuGGAAAuGGAudTsdT sense 1703-1722 9694 AUCCAUUUCCAAUCACUUU
11694 AUCcAUUUCcAAUcACUUUdTsdT antis 1735-1754 9695
AUAUCAAGCCAAACUUUGU 11695 AuAucAAGccAAAcuuuGudTsdT sense 1735-1754
9696 ACAAAGUUUGGCUUGAUAU 11696 AcAAAGUUUGGCUUGAuAUdTsdT antis
1741-1760 9697 AGCCAAACUUUGUGAUUCU 11697 AGccAAAcuuuGuGAuucudTsdT
sense 1741-1760 9698 AGAAUCACAAAGUUUGGCU 11698
AGAAUcAcAAAGUUUGGCUdTsdT antis 1773-1792 9699 CCAUCAAGAAAGUUCUACA
11699 ccAucAAGAAAGuucuAcAdTsdT sense 1773-1792 9700
UGUAGAACUUUCUUGAUGG 11700 UGuAGAACUUUCUUGAUGGdTsdT antis 1774-1793
9701 CAUCAAGAAAGUUCUACAG 11701 cAucAAGAAAGuucuAcAGdTsdT sense
1774-1793 9702 CUGUAGAACUUUCUUGAUG 11702 CUGuAGAACUUUCUUGAUGdTsdT
antis 1784-1803 9703 GUUCUACAGGACAAGCGAU 11703
GuucuAcAGGAcAAGcGAudTsdT sense 1784-1803 9704 AUCGCUUGUCCUGUAGAAC
11704 AUCGCUUGUCCUGuAGAACdTsdT antis 1823-1842 9705
AUCAUGAGAAAGCUAGACC 11705 AucAuGAGAAAGcuAGAccdTsdT sense 1823-1842
9706 GGUCUAGCUUUCUCAUGAU 11706 GGUCuAGCUUUCUcAUGAUdTsdT antis
1868-1887 9707 UUCUUCUACUCGAGUGGUG 11707 uucuucuAcucGAGuGGuGdTsdT
sense 1868-1887 9708 CACCACUCGAGUAGAAGAA 11708
cACcACUCGAGuAGAAGAAdTsdT antis 1876-1895 9709 CUCGAGUGGUGAGAAGAAA
11709 cucGAGuGGuGAGAAGAAAdTsdT sense 1876-1895 9710
UUUCUUCUCACCACUCGAG 11710 UUUCUUCUcACcACUCGAGdTsdT antis 1907-1926
9711 CUUAACCUGGUGCUGGACU 11711 cuuAAccuGGuGcuGGAcudTsdT sense
1907-1926 9712 AGUCCAGCACCAGGUUAAG 11712 AGUCcAGcACcAGGUuAAGdTsdT
antis 1910-1929 9713 AACCUGGUGCUGGACUAUG 11713
AAccuGGuGcuGGAcuAuGdTsdT sense 1910-1929 9714 CAUAGUCCAGCACCAGGUU
11714 cAuAGUCcAGcACcAGGUUdTsdT antis 1930-1949 9715
UCCGGAGACAGUGUACAGA 11715 uccGGAGAcAGuGuAcAGAdTsdT sense 1930-1949
9716 UCUGUACACUGUCUCCGGA 11716 UCUGuAcACUGUCUCCGGAdTsdT antis
1939-1958 9717 AGUGUACAGAGUCGCCAGA 11717 AGuGuAcAGAGucGccAGAdTsdT
sense 1939-1958 9718 UCUGGCGACUCUGUACACU 11718
UCUGGCGACUCUGuAcACUdTsdT antis 1940-1959 9719 GUGUACAGAGUCGCCAGAC
11719 GuGuAcAGAGucGccAGAcdTsdT sense 1940-1959 9720
GUCUGGCGACUCUGUACAC 11720 GUCUGGCGACUCUGuAcACdTsdT antis 1943-1962
9721 UACAGAGUCGCCAGACACU 11721 uAcAGAGucGccAGAcAcudTsdT sense
1943-1962 9722 AGUGUCUGGCGACUCUGUA 11722 AGUGUCUGGCGACUCUGuAdTsdT
antis 1946-1965 9723 AGAGUCGCCAGACACUAUA 11723
AGAGucGccAGAcAcuAuAdTsdT sense 1946-1965 9724 UAUAGUGUCUGGCGACUCU
11724 uAuAGUGUCUGGCGACUCUdTsdT antis 1948-1967 9725
AGUCGCCAGACACUAUAGU 11725 AGucGccAGAcAcuAuAGudTsdT sense 1948-1967
9726 ACUAUAGUGUCUGGCGACU 11726 ACuAuAGUGUCUGGCGACUdTsdT antis
1963-1982 9727 UAGUCGAGCCAAGCAGACA 11727 uAGucGAGccAAGcAGAcAdTsdT
sense 1963-1982 9728 UGUCUGCUUGGCUCGACUA 11728
UGUCUGCUUGGCUCGACuAdTsdT antis 1987-2006 9729 UGUGAUCUAUGUCAAGUUG
11729 uGuGAucuAuGucAAGuuGdTsdT sense 1987-2006 9730
CAACUUGACAUAGAUCACA 11730 cAACUUGAcAuAGAUcAcAdTsdT antis 1991-2010
9731 AUCUAUGUCAAGUUGUAUA 11731 AucuAuGucAAGuuGuAuAdTsdT sense
1991-2010 9732 UAUACAACUUGACAUAGAU 11732 uAuAcAACUUGAcAuAGAUdTsdT
antis 1992-2011 9733 UCUAUGUCAAGUUGUAUAU 11733
ucuAuGucAAGuuGuAuAudTsdT sense 1992-2011 9734 AUAUACAACUUGACAUAGA
11734 AuAuAcAACUUGAcAuAGAdTsdT antis 2000-2019 9735
AAGUUGUAUAUGUAUCAGC 11735 AAGuuGuAuAuGuAucAGcdTsdT sense 2000-2019
9736 GCUGAUACAUAUACAACUU 11736 GCUGAuAcAuAuAcAACUUdTsdT antis
2001-2020 9737 AGUUGUAUAUGUAUCAGCU 11737 AGuuGuAuAuGuAucAGcudTsdT
sense 2001-2020 9738 AGCUGAUACAUAUACAACU 11738
AGCUGAuAcAuAuAcAACUdTsdT antis 2004-2023 9739 UGUAUAUGUAUCAGCUGUU
11739 uGuAuAuGuAucAGcuGuudTsdT sense 2004-2023 9740
AACAGCUGAUACAUAUACA 11740 AAcAGCUGAuAcAuAuAcAdTsdT antis 2007-2026
9741 AUAUGUAUCAGCUGUUCAG 11741 AuAuGuAucAGcuGuucAGdTsdT sense
2007-2026 9742 CUGAACAGCUGAUACAUAU 11742 CUGAAcAGCUGAuAcAuAUdTsdT
antis 2048-2067 9743 UUUGGAAUCUGCCAUCGAG 11743
uuuGGAAucuGccAucGAGdTsdT sense 2048-2067 9744 CUCGAUGGCAGAUUCCAAA
11744 CUCGAUGGcAGAUUCcAAAdTsdT antis 2100-2119 9745
AUACAGCUGUAUUAAAACU 11745 AuAcAGcuGuAuuAAAAcudTsdT sense 2100-2119
9746 AGUUUUAAUACAGCUGUAU 11746 AGUUUuAAuAcAGCUGuAUdTsdT antis
2107-2126 9747 UGUAUUAAAACUCUGUGAC 11747 uGuAuuAAAAcucuGuGAcdTsdT
sense 2107-2126 9748 GUCACAGAGUUUUAAUACA 11748
GUcAcAGAGUUUuAAuAcAdTsdT antis 2151-2170 9749 GAGGAGAGCCCAAUGUUUC
11749 GAGGAGAGcccAAuGuuucdTsdT sense 2151-2170 9750
GAAACAUUGGGCUCUCCUC 11750 GAAAcAUUGGGCUCUCCUCdTsdT antis 2158-2177
9751 GCCCAAUGUUUCAUAUAUC 11751 GcccAAuGuuucAuAuAucdTsdT sense
2158-2177 9752 GAUAUAUGAAACAUUGGGC 11752 GAuAuAUGAAAcAUUGGGCdTsdT
antis 2166-2185 9753 UUUCAUAUAUCUGUUCUCG 11753
uuucAuAuAucuGuucucGdTsdT sense 2166-2185 9754 CGAGAACAGAUAUAUGAAA
11754 CGAGAAcAGAuAuAUGAAAdTsdT antis 2172-2191 9755
AUAUCUGUUCUCGGUACUA 11755 AuAucuGuucucGGuAcuAdTsdT sense 2172-2191
9756 UAGUACCGAGAACAGAUAU 11756 uAGuACCGAGAAcAGAuAUdTsdT antis
2183-2202 9757 CGGUACUACAGGGCACCAG 11757 cGGuAcuAcAGGGcAccAGdTsdT
sense 2183-2202 9758 CUGGUGCCCUGUAGUACCG 11758
CUGGUGCCCUGuAGuACCGdTsdT antis 2232-2251 9759 CCAGUAUAGAUGUAUGGUC
11759 ccAGuAuAGAuGuAuGGucdTsdT sense 2232-2251 9760
GACCAUACAUCUAUACUGG 11760 GACcAuAcAUCuAuACUGGdTsdT antis 2273-2292
9761 UUGUUGCUAGGACAACCAA 11761 uuGuuGcuAGGAcAAccAAdTsdT sense
2273-2292 9762 UUGGUUGUCCUAGCAACAA 11762 UUGGUUGUCCuAGcAAcAAdTsdT
antis 2274-2293 9763 UGUUGCUAGGACAACCAAU 11763
uGuuGcuAGGAcAAccAAudTsdT sense 2274-2293 9764 AUUGGUUGUCCUAGCAACA
11764 AUUGGUUGUCCuAGcAAcAdTsdT antis 2318-2337 9765
CAGUUGGUGGAAAUAAUAA 11765 cAGuuGGuGGAAAuAAuAAdTsdT sense 2318-2337
9766 UUAUUAUUUCCACCAACUG 11766 UuAUuAUUUCcACcAACUGdTsdT antis
2361-2380 9767 AGCAAAUUAGAGAAAUGAA 11767 AGcAAAuuAGAGAAAuGAAdTsdT
sense 2361-2380 9768 UUCAUUUCUCUAAUUUGCU 11768
UUcAUUUCUCuAAUUUGCUdTsdT antis 2380-2399 9769 CCCAAAUUAUACAGAAUUC
11769 cccAAAuuAuAcAGAAuucdTsdT sense 2380-2399 9770
GAAUUCUGUAUAAUUUGGG 11770 GAAUUCUGuAuAAUUUGGGdTsdT antis 2400-2419
9771 AAUUCCCUCAAAUCAAGGC 11771 AAuucccucAAAucAAGGcdTsdT sense
2400-2419 9772 GCCUUGAUUUGAGGGAAUU 11772 GCCUUGAUUUGAGGGAAUUdTsdT
antis 2409-2428 9773 AAAUCAAGGCACAUCCUUG 11773
AAAucAAGGcAcAuccuuGdTsdT sense 2409-2428 9774 CAAGGAUGUGCCUUGAUUU
11774 cAAGGAUGUGCCUUGAUUUdTsdT antis 2445-2464 9775
CCCGAACUCCACCAGAGGC 11775 cccGAAcuccAccAGAGGcdTsdT sense 2445-2464
9776 GCCUCUGGUGGAGUUCGGG 11776 GCCUCUGGUGGAGUUCGGGdTsdT antis
2479-2498 9777 CCGUCUGCUGGAGUACACA 11777 ccGucuGcuGGAGuAcAcAdTsdT
sense 2479-2498 9778 UGUGUACUCCAGCAGACGG 11778
UGUGuACUCcAGcAGACGGdTsdT antis 2489-2508 9779 GAGUACACACCUACCGCCC
11779 GAGuAcAcAccuAccGcccdTsdT sense 2489-2508 9780
GGGCGGUAGGUGUGUACUC 11780 GGGCGGuAGGUGUGuACUCdTsdT antis 1819-1838
9781 CCAGAUCAUGAGAAAGCUA 11781 ccAGAucAuGAGAAAGcuAdTsdT sense
1819-1838 9782 UAGCUUUCUCAUGAUCUGG 11782 uAGCUUUCUcAUGAUCUGGdTsdT
antis 2030-2049 9783 CUAGCCUAUAUCCAUUCCU 11783
cuAGccuAuAuccAuuccudTsdT sense 2030-2049 9784 AGGAAUGGAUAUAGGCUAG
11784 AGGAAUGGAuAuAGGCuAGdTsdT antis 2154-2173 9785
GAGAGCCCAAUGUUUCAUA 11785 GAGAGcccAAuGuuucAuAdTsdT sense 2154-2173
9786 UAUGAAACAUUGGGCUCUC 11786 uAUGAAAcAUUGGGCUCUCdTsdT antis
2184-2203 9787 GGUACUACAGGGCACCAGA 11787 GGuAcuAcAGGGcAccAGAdTsdT
sense 2184-2203 9788 UCUGGUGCCCUGUAGUACC 11788
UCUGGUGCCCUGuAGuACCdTsdT antis 2190-2209 9789 ACAGGGCACCAGAGUUGAU
11789 AcAGGGcAccAGAGuuGAudTsdT sense 2190-2209 9790
AUCAACUCUGGUGCCCUGU 11790 AUcAACUCUGGUGCCCUGUdTsdT antis 2314-2333
9791 GGAUCAGUUGGUGGAAAUA 11791 GGAucAGuuGGuGGAAAuAdTsdT sense
2314-2333 9792 UAUUUCCACCAACUGAUCC 11792 uAUUUCcACcAACUGAUCCdTsdT
antis 2428-2447 9793 GACAAAGGUCUUCCGGCCC 11793
GAcAAAGGucuuccGGcccdTsdT sense 2428-2447 9794 GGGCCGGAAGACCUUUGUC
11794 GGGCCGGAAGACCUUUGUCdTsdT antis 1913-1932 9795
CUGGUGCUGGACUAUGUUC 11795 cuGGuGcuGGAcuAuGuucdTsdT sense 1913-1932
9796 GAACAUAGUCCAGCACCAG 11796 GAAcAuAGUCcAGcACcAGdTsdT antis
1530-1549 9797 CGGGGCGACCGAGAACCAC 11797 cGGGGcGAccGAGAAccAcdTsdT
sense 1530-1549 9798 GUGGUUCUCGGUCGCCCCG 11798
GUGGUUCUCGGUCGCCCCGdTsdT antis 1549-1568 9799 CUCCUUUGCGGAGAGCUGC
11799 cuccuuuGcGGAGAGcuGcdTsdT sense 1549-1568 9800
GCAGCUCUCCGCAAAGGAG 11800 GcAGCUCUCCGcAAAGGAGdTsdT antis 1550-1569
9801 UCCUUUGCGGAGAGCUGCA 11801 uccuuuGcGGAGAGcuGcAdTsdT sense
1550-1569 9802 UGCAGCUCUCCGCAAAGGA 11802 UGcAGCUCUCCGcAAAGGAdTsdT
antis 1610-1629 9803 AGCAGAGAUAAAGAUGGCA 11803
AGcAGAGAuAAAGAuGGcAdTsdT sense 1610-1629 9804 UGCCAUCUUUAUCUCUGCU
11804 UGCcAUCUUuAUCUCUGCUdTsdT antis 1642-1661 9805
AGUAGUGGCAACUCCUGGC 11805 AGuAGuGGcAAcuccuGGcdTsdT sense 1642-1661
9806 GCCAGGAGUUGCCACUACU 11806 GCcAGGAGUUGCcACuACUdTsdT antis
1643-1662 9807 GUAGUGGCAACUCCUGGCC 11807 GuAGuGGcAAcuccuGGccdTsdT
sense 1643-1662 9808 GGCCAGGAGUUGCCACUAC 11808
GGCcAGGAGUUGCcACuACdTsdT antis 1696-1715 9809 AGACACGAAAGUGAUUGGA
11809 AGAcAcGAAAGuGAuuGGAdTsdT sense 1696-1715 9810
UCCAAUCACUUUCGUGUCU 11810 UCcAAUcACUUUCGUGUCUdTsdT antis 1704-1723
9811 AAGUGAUUGGAAAUGGAUC 11811 AAGuGAuuGGAAAuGGAucdTsdT sense
1704-1723 9812 GAUCCAUUUCCAAUCACUU 11812 GAUCcAUUUCcAAUcACUUdTsdT
antis 1719-1738 9813 GAUCAUUUGGUGUGGUAUA 11813
GAucAuuuGGuGuGGuAuAdTsdT sense 1719-1738 9814 UAUACCACACCAAAUGAUC
11814 uAuACcAcACcAAAUGAUCdTsdT antis 1728-1747 9815
GUGUGGUAUAUCAAGCCAA 11815 GuGuGGuAuAucAAGccAAdTsdT sense 1728-1747
9816 UUGGCUUGAUAUACCACAC 11816 UUGGCUUGAuAuACcAcACdTsdT antis
1731-1750 9817 UGGUAUAUCAAGCCAAACU 11817 uGGuAuAucAAGccAAAcudTsdT
sense 1731-1750 9818 AGUUUGGCUUGAUAUACCA 11818
AGUUUGGCUUGAuAuACcAdTsdT antis 1732-1751 9819 GGUAUAUCAAGCCAAACUU
11819 GGuAuAucAAGccAAAcuudTsdT sense 1732-1751 9820
AAGUUUGGCUUGAUAUACC 11820 AAGUUUGGCUUGAuAuACCdTsdT antis 1733-1752
9821 GUAUAUCAAGCCAAACUUU 11821 GuAuAucAAGccAAAcuuudTsdT sense
1733-1752 9822 AAAGUUUGGCUUGAUAUAC 11822 AAAGUUUGGCUUGAuAuACdTsdT
antis 1768-1787 9823 GGUUGCCAUCAAGAAAGUU 11823
GGuuGccAucAAGAAAGuudTsdT sense 1768-1787 9824 AACUUUCUUGAUGGCAACC
11824 AACUUUCUUGAUGGcAACCdTsdT antis 1800-1819 9825
GAUUUAAGAACCGAGAGCU 11825 GAuuuAAGAAccGAGAGcudTsdT sense 1800-1819
9826 AGCUCUCGGUUCUUAAAUC 11826 AGCUCUCGGUUCUuAAAUCdTsdT antis
1802-1821 9827 UUUAAGAACCGAGAGCUCC 11827 uuuAAGAAccGAGAGcuccdTsdT
sense 1802-1821 9828 GGAGCUCUCGGUUCUUAAA 11828
GGAGCUCUCGGUUCUuAAAdTsdT antis 1821-1840 9829 AGAUCAUGAGAAAGCUAGA
11829 AGAucAuGAGAAAGcuAGAdTsdT sense 1821-1840 9830
UCUAGCUUUCUCAUGAUCU 11830 UCuAGCUUUCUcAUGAUCUdTsdT antis 1830-1849
9831 GAAAGCUAGACCACUGUAA 11831 GAAAGcuAGAccAcuGuAAdTsdT sense
1830-1849 9832 UUACAGUGGUCUAGCUUUC 11832 UuAcAGUGGUCuAGCUUUCdTsdT
antis 1831-1850 9833 AAAGCUAGACCACUGUAAC 11833
AAAGcuAGAccAcuGuAAcdTsdT sense 1831-1850 9834 GUUACAGUGGUCUAGCUUU
11834 GUuAcAGUGGUCuAGCUUUdTsdT antis 1856-1875 9835
CGACUGCGGUAUUUCUUCU 11835 cGAcuGcGGuAuuucuucudTsdT sense 1856-1875
9836 AGAAGAAAUACCGCAGUCG 11836 AGAAGAAAuACCGcAGUCGdTsdT antis
1857-1876 9837 GACUGCGGUAUUUCUUCUA 11837 GAcuGcGGuAuuucuucuAdTsdT
sense 1857-1876 9838 UAGAAGAAAUACCGCAGUC 11838
uAGAAGAAAuACCGcAGUCdTsdT antis 1875-1894 9839 ACUCGAGUGGUGAGAAGAA
11839 AcucGAGuGGuGAGAAGAAdTsdT sense 1875-1894 9840
UUCUUCUCACCACUCGAGU 11840 UUCUUCUcACcACUCGAGUdTsdT antis 1877-1896
9841 UCGAGUGGUGAGAAGAAAG 11841 ucGAGuGGuGAGAAGAAAGdTsdT sense
1877-1896 9842 CUUUCUUCUCACCACUCGA 11842 CUUUCUUCUcACcACUCGAdTsdT
antis 1897-1916 9843 UGAGGUCUACCUUAACCUG 11843
uGAGGucuAccuuAAccuGdTsdT sense 1897-1916 9844 CAGGUUAAGGUAGACCUCA
11844 cAGGUuAAGGuAGACCUcAdTsdT antis 1908-1927 9845
UUAACCUGGUGCUGGACUA 11845 uuAAccuGGuGcuGGAcuAdTsdT sense 1908-1927
9846 UAGUCCAGCACCAGGUUAA 11846 uAGUCcAGcACcAGGUuAAdTsdT antis
1923-1942 9847 ACUAUGUUCCGGAGACAGU 11847 AcuAuGuuccGGAGAcAGudTsdT
sense 1923-1942 9848 ACUGUCUCCGGAACAUAGU 11848
ACUGUCUCCGGAAcAuAGUdTsdT antis 1928-1947 9849 GUUCCGGAGACAGUGUACA
11849 GuuccGGAGAcAGuGuAcAdTsdT sense 1928-1947 9850
UGUACACUGUCUCCGGAAC 11850 UGuAcACUGUCUCCGGAACdTsdT antis 1934-1953
9851 GAGACAGUGUACAGAGUCG 11851 GAGAcAGuGuAcAGAGucGdTsdT sense
1934-1953 9852 CGACUCUGUACACUGUCUC 11852 CGACUCUGuAcACUGUCUCdTsdT
antis 1951-1970 9853 CGCCAGACACUAUAGUCGA 11853
cGccAGAcAcuAuAGucGAdTsdT sense 1951-1970 9854 UCGACUAUAGUGUCUGGCG
11854 UCGACuAuAGUGUCUGGCGdTsdT antis 1981-2000 9855
ACUCCCUGUGAUCUAUGUC 11855 AcucccuGuGAucuAuGucdTsdT sense 1981-2000
9856 GACAUAGAUCACAGGGAGU 11856 GAcAuAGAUcAcAGGGAGUdTsdT antis
1983-2002 9857 UCCCUGUGAUCUAUGUCAA 11857 ucccuGuGAucuAuGucAAdTsdT
sense
1983-2002 9858 UUGACAUAGAUCACAGGGA 11858 UUGAcAuAGAUcAcAGGGAdTsdT
antis 1994-2013 9859 UAUGUCAAGUUGUAUAUGU 11859
uAuGucAAGuuGuAuAuGudTsdT sense 1994-2013 9860 ACAUAUACAACUUGACAUA
11860 AcAuAuAcAACUUGAcAuAdTsdT antis 2003-2022 9861
UUGUAUAUGUAUCAGCUGU 11861 uuGuAuAuGuAucAGcuGudTsdT sense 2003-2022
9862 ACAGCUGAUACAUAUACAA 11862 AcAGCUGAuAcAuAuAcAAdTsdT antis
2067-2086 9863 ACAUUAAACCACAGAACCU 11863 AcAuuAAAccAcAGAAccudTsdT
sense 2067-2086 9864 AGGUUCUGUGGUUUAAUGU 11864
AGGUUCUGUGGUUuAAUGUdTsdT antis 2077-2096 9865 ACAGAACCUCUUGUUGGAU
11865 AcAGAAccucuuGuuGGAudTsdT sense 2077-2096 9866
AUCCAACAAGAGGUUCUGU 11866 AUCcAAcAAGAGGUUCUGUdTsdT antis 2079-2098
9867 AGAACCUCUUGUUGGAUCC 11867 AGAAccucuuGuuGGAuccdTsdT sense
2079-2098 9868 GGAUCCAACAAGAGGUUCU 11868 GGAUCcAAcAAGAGGUUCUdTsdT
antis 2087-2106 9869 UUGUUGGAUCCUGAUACAG 11869
uuGuuGGAuccuGAuAcAGdTsdT sense 2087-2106 9870 CUGUAUCAGGAUCCAACAA
11870 CUGuAUcAGGAUCcAAcAAdTsdT antis 2093-2112 9871
GAUCCUGAUACAGCUGUAU 11871 GAuccuGAuAcAGcuGuAudTsdT sense 2093-2112
9872 AUACAGCUGUAUCAGGAUC 11872 AuAcAGCUGuAUcAGGAUCdTsdT antis
2099-2118 9873 GAUACAGCUGUAUUAAAAC 11873 GAuAcAGcuGuAuuAAAAcdTsdT
sense 2099-2118 9874 GUUUUAAUACAGCUGUAUC 11874
GUUUuAAuAcAGCUGuAUCdTsdT antis 2135-2154 9875 GCAAAGCAGCUGGUCCGAG
11875 GcAAAGcAGcuGGuccGAGdTsdT sense 2135-2154 9876
CUCGGACCAGCUGCUUUGC 11876 CUCGGACcAGCUGCUUUGCdTsdT antis 2150-2169
9877 CGAGGAGAGCCCAAUGUUU 11877 cGAGGAGAGcccAAuGuuudTsdT sense
2150-2169 9878 AAACAUUGGGCUCUCCUCG 11878 AAAcAUUGGGCUCUCCUCGdTsdT
antis 2157-2176 9879 AGCCCAAUGUUUCAUAUAU 11879
AGcccAAuGuuucAuAuAudTsdT sense 2157-2176 9880 AUAUAUGAAACAUUGGGCU
11880 AuAuAUGAAAcAUUGGGCUdTsdT antis 2198-2217 9881
CCAGAGUUGAUCUUUGGAG 11881 ccAGAGuuGAucuuuGGAGdTsdT sense 2198-2217
9882 CUCCAAAGAUCAACUCUGG 11882 CUCcAAAGAUcAACUCUGGdTsdT antis
2199-2218 9883 CAGAGUUGAUCUUUGGAGC 11883 cAGAGuuGAucuuuGGAGcdTsdT
sense 2199-2218 9884 GCUCCAAAGAUCAACUCUG 11884
GCUCcAAAGAUcAACUCUGdTsdT antis 2216-2235 9885 GCCACUGAUUACACGUCCA
11885 GccAcuGAuuAcAcGuccAdTsdT sense 2216-2235 9886
UGGACGUGUAAUCAGUGGC 11886 UGGACGUGuAAUcAGUGGCdTsdT antis 2237-2256
9887 AUAGAUGUAUGGUCUGCAG 11887 AuAGAuGuAuGGucuGcAGdTsdT sense
2237-2256 9888 CUGCAGACCAUACAUCUAU 11888 CUGcAGACcAuAcAUCuAUdTsdT
antis 2243-2262 9889 GUAUGGUCUGCAGGCUGUG 11889
GuAuGGucuGcAGGcuGuGdTsdT sense 2243-2262 9890 CACAGCCUGCAGACCAUAC
11890 cAcAGCCUGcAGACcAuACdTsdT antis 2272-2291 9891
AUUGUUGCUAGGACAACCA 11891 AuuGuuGcuAGGAcAAccAdTsdT sense 2272-2291
9892 UGGUUGUCCUAGCAACAAU 11892 UGGUUGUCCuAGcAAcAAUdTsdT antis
2283-2302 9893 GACAACCAAUAUUUCCUGG 11893 GAcAAccAAuAuuuccuGGdTsdT
sense 2283-2302 9894 CCAGGAAAUAUUGGUUGUC 11894
CcAGGAAAuAUUGGUUGUCdTsdT antis 2291-2310 9895 AUAUUUCCUGGGGACAGUG
11895 AuAuuuccuGGGGAcAGuGdTsdT sense 2291-2310 9896
CACUGUCCCCAGGAAAUAU 11896 cACUGUCCCcAGGAAAuAUdTsdT antis 2311-2330
9897 UGUGGAUCAGUUGGUGGAA 11897 uGuGGAucAGuuGGuGGAAdTsdT sense
2311-2330 9898 UUCCACCAACUGAUCCACA 11898 UUCcACcAACUGAUCcAcAdTsdT
antis 2353-2372 9899 AACAAGGGAGCAAAUUAGA 11899
AAcAAGGGAGcAAAuuAGAdTsdT sense 2353-2372 9900 UCUAAUUUGCUCCCUUGUU
11900 UCuAAUUUGCUCCCUUGUUdTsdT antis 2359-2378 9901
GGAGCAAAUUAGAGAAAUG 11901 GGAGcAAAuuAGAGAAAuGdTsdT sense 2359-2378
9902 CAUUUCUCUAAUUUGCUCC 11902 cAUUUCUCuAAUUUGCUCCdTsdT antis
2379-2398 9903 ACCCAAAUUAUACAGAAUU 11903 AcccAAAuuAuAcAGAAuudTsdT
sense 2379-2398 9904 AAUUCUGUAUAAUUUGGGU 11904
AAUUCUGuAuAAUUUGGGUdTsdT antis 2408-2427 9905 CAAAUCAAGGCACAUCCUU
11905 cAAAucAAGGcAcAuccuudTsdT sense 2408-2427 9906
AAGGAUGUGCCUUGAUUUG 11906 AAGGAUGUGCCUUGAUUUGdTsdT antis 2412-2431
9907 UCAAGGCACAUCCUUGGAC 11907 ucAAGGcAcAuccuuGGAcdTsdT sense
2412-2431 9908 GUCCAAGGAUGUGCCUUGA 11908 GUCcAAGGAUGUGCCUUGAdTsdT
antis 2438-2457 9909 UUCCGGCCCCGAACUCCAC 11909
uuccGGccccGAAcuccAcdTsdT sense 2438-2457 9910 GUGGAGUUCGGGGCCGGAA
11910 GUGGAGUUCGGGGCCGGAAdTsdT antis 2476-2495 9911
CAGCCGUCUGCUGGAGUAC 11911 cAGccGucuGcuGGAGuAcdTsdT sense 2476-2495
9912 GUACUCCAGCAGACGGCUG 11912 GuACUCcAGcAGACGGCUGdTsdT antis
2477-2496 9913 AGCCGUCUGCUGGAGUACA 11913 AGccGucuGcuGGAGuAcAdTsdT
sense 2477-2496 9914 UGUACUCCAGCAGACGGCU 11914
UGuACUCcAGcAGACGGCUdTsdT antis 2478-2497 9915 GCCGUCUGCUGGAGUACAC
11915 GccGucuGcuGGAGuAcAcdTsdT sense 2478-2497 9916
GUGUACUCCAGCAGACGGC 11916 GUGuACUCcAGcAGACGGCdTsdT antis 2484-2503
9917 UGCUGGAGUACACACCUAC 11917 uGcuGGAGuAcAcAccuAcdTsdT sense
2484-2503 9918 GUAGGUGUGUACUCCAGCA 11918 GuAGGUGUGuACUCcAGcAdTsdT
antis 1527-1546 9919 UGUCGGGGCGACCGAGAAC 11919
uGucGGGGcGAccGAGAAcdTsdT sense 1527-1546 9920 GUUCUCGGUCGCCCCGACA
11920 GUUCUCGGUCGCCCCGAcAdTsdT antis 1531-1550 9921
GGGGCGACCGAGAACCACC 11921 GGGGcGAccGAGAAccAccdTsdT sense 1531-1550
9922 GGUGGUUCUCGGUCGCCCC 11922 GGUGGUUCUCGGUCGCCCCdTsdT antis
1536-1555 9923 GACCGAGAACCACCUCCUU 11923 GAccGAGAAccAccuccuudTsdT
sense 1536-1555 9924 AAGGAGGUGGUUCUCGGUC 11924
AAGGAGGUGGUUCUCGGUCdTsdT antis 1542-1561 9925 GAACCACCUCCUUUGCGGA
11925 GAAccAccuccuuuGcGGAdTsdT sense 1542-1561 9926
UCCGCAAAGGAGGUGGUUC 11926 UCCGcAAAGGAGGUGGUUCdTsdT antis 1552-1571
9927 CUUUGCGGAGAGCUGCAAG 11927 cuuuGcGGAGAGcuGcAAGdTsdT sense
1552-1571 9928 CUUGCAGCUCUCCGCAAAG 11928 CUUGcAGCUCUCCGcAAAGdTsdT
antis 1556-1575 9929 GCGGAGAGCUGCAAGCCAG 11929
GcGGAGAGcuGcAAGccAGdTsdT sense 1556-1575 9930 CUGGCUUGCAGCUCUCCGC
11930 CUGGCUUGcAGCUCUCCGCdTsdT antis 1564-1583 9931
CUGCAAGCCAGUGCAGCAG 11931 cuGcAAGccAGuGcAGcAGdTsdT sense 1564-1583
9932 CUGCUGCACUGGCUUGCAG 11932 CUGCUGcACUGGCUUGcAGdTsdT antis
1572-1591 9933 CAGUGCAGCAGCCUUCAGC 11933 cAGuGcAGcAGccuucAGcdTsdT
sense 1572-1591 9934 GCUGAAGGCUGCUGCACUG 11934
GCUGAAGGCUGCUGcACUGdTsdT antis 1578-1597 9935 AGCAGCCUUCAGCUUUUGG
11935 AGcAGccuucAGcuuuuGGdTsdT sense 1578-1597 9936
CCAAAAGCUGAAGGCUGCU 11936 CcAAAAGCUGAAGGCUGCUdTsdT antis 1579-1598
9937 GCAGCCUUCAGCUUUUGGU 11937 GcAGccuucAGcuuuuGGudTsdT sense
1579-1598 9938 ACCAAAAGCUGAAGGCUGC 11938 ACcAAAAGCUGAAGGCUGCdTsdT
antis 1581-1600 9939 AGCCUUCAGCUUUUGGUAG 11939
AGccuucAGcuuuuGGuAGdTsdT sense 1581-1600 9940 CUACCAAAAGCUGAAGGCU
11940 CuACcAAAAGCUGAAGGCUdTsdT antis 1582-1601 9941
GCCUUCAGCUUUUGGUAGC 11941 GccuucAGcuuuuGGuAGcdTsdT sense 1582-1601
9942 GCUACCAAAAGCUGAAGGC 11942 GCuACcAAAAGCUGAAGGCdTsdT antis
1585-1604 9943 UUCAGCUUUUGGUAGCAUG 11943 uucAGcuuuuGGuAGcAuGdTsdT
sense 1585-1604 9944 CAUGCUACCAAAAGCUGAA 11944
cAUGCuACcAAAAGCUGAAdTsdT antis 1587-1606 9945 CAGCUUUUGGUAGCAUGAA
11945 cAGcuuuuGGuAGcAuGAAdTsdT sense 1587-1606 9946
UUCAUGCUACCAAAAGCUG 11946 UUcAUGCuACcAAAAGCUGdTsdT antis 1588-1607
9947 AGCUUUUGGUAGCAUGAAA 11947 AGcuuuuGGuAGcAuGAAAdTsdT sense
1588-1607 9948 UUUCAUGCUACCAAAAGCU 11948 UUUcAUGCuACcAAAAGCUdTsdT
antis 1598-1617 9949 AGCAUGAAAGUUAGCAGAG 11949
AGcAuGAAAGuuAGcAGAGdTsdT sense 1598-1617 9950 CUCUGCUAACUUUCAUGCU
11950 CUCUGCuAACUUUcAUGCUdTsdT antis 1602-1621 9951
UGAAAGUUAGCAGAGAUAA 11951 uGAAAGuuAGcAGAGAuAAdTsdT sense 1602-1621
9952 UUAUCUCUGCUAACUUUCA 11952 UuAUCUCUGCuAACUUUcAdTsdT antis
1618-1637 9953 UAAAGAUGGCAGCAAGGUA 11953 uAAAGAuGGcAGcAAGGuAdTsdT
sense 1618-1637 9954 UACCUUGCUGCCAUCUUUA 11954
uACCUUGCUGCcAUCUUuAdTsdT antis 1619-1638 9955 AAAGAUGGCAGCAAGGUAA
11955 AAAGAuGGcAGcAAGGuAAdTsdT sense 1619-1638 9956
UUACCUUGCUGCCAUCUUU 11956 UuACCUUGCUGCcAUCUUUdTsdT antis 1625-1644
9957 GGCAGCAAGGUAACCACAG 11957 GGcAGcAAGGuAAccAcAGdTsdT sense
1625-1644 9958 CUGUGGUUACCUUGCUGCC 11958 CUGUGGUuACCUUGCUGCCdTsdT
antis 1627-1646 9959 CAGCAAGGUAACCACAGUA 11959
cAGcAAGGuAAccAcAGuAdTsdT sense 1627-1646 9960 UACUGUGGUUACCUUGCUG
11960 uACUGUGGUuACCUUGCUGdTsdT antis 1636-1655 9961
AACCACAGUAGUGGCAACU 11961 AAccAcAGuAGuGGcAAcudTsdT sense 1636-1655
9962 AGUUGCCACUACUGUGGUU 11962 AGUUGCcACuACUGUGGUUdTsdT antis
1637-1656 9963 ACCACAGUAGUGGCAACUC 11963 AccAcAGuAGuGGcAAcucdTsdT
sense 1637-1656 9964 GAGUUGCCACUACUGUGGU 11964
GAGUUGCcACuACUGUGGUdTsdT antis 1646-1665 9965 GUGGCAACUCCUGGCCAGG
11965 GuGGcAAcuccuGGccAGGdTsdT sense 1646-1665 9966
CCUGGCCAGGAGUUGCCAC 11966 CCUGGCcAGGAGUUGCcACdTsdT antis 1648-1667
9967 GGCAACUCCUGGCCAGGGU 11967 GGcAAcuccuGGccAGGGudTsdT sense
1648-1667 9968 ACCCUGGCCAGGAGUUGCC 11968 ACCCUGGCcAGGAGUUGCCdTsdT
antis 1649-1668 9969 GCAACUCCUGGCCAGGGUC 11969
GcAAcuccuGGccAGGGucdTsdT sense 1649-1668 9970 GACCCUGGCCAGGAGUUGC
11970 GACCCUGGCcAGGAGUUGCdTsdT antis 1651-1670 9971
AACUCCUGGCCAGGGUCCU 11971 AAcuccuGGccAGGGuccudTsdT sense 1651-1670
9972 AGGACCCUGGCCAGGAGUU 11972 AGGACCCUGGCcAGGAGUUdTsdT antis
1666-1685 9973 UCCUGACAGGCCACAGGAA 11973 uccuGAcAGGccAcAGGAAdTsdT
sense 1666-1685 9974 UUCCUGUGGCCUGUCAGGA 11974
UUCCUGUGGCCUGUcAGGAdTsdT antis 1667-1686 9975 CCUGACAGGCCACAGGAAG
11975 ccuGAcAGGccAcAGGAAGdTsdT sense 1667-1686 9976
CUUCCUGUGGCCUGUCAGG 11976 CUUCCUGUGGCCUGUcAGGdTsdT antis 1669-1688
9977 UGACAGGCCACAGGAAGUC 11977 uGAcAGGccAcAGGAAGucdTsdT sense
1669-1688 9978 GACUUCCUGUGGCCUGUCA 11978 GACUUCCUGUGGCCUGUcAdTsdT
antis 1670-1689 9979 GACAGGCCACAGGAAGUCA 11979
GAcAGGccAcAGGAAGucAdTsdT sense 1670-1689 9980 UGACUUCCUGUGGCCUGUC
11980 UGACUUCCUGUGGCCUGUCdTsdT antis 1685-1704 9981
GUCAGUUAUACAGACACGA 11981 GucAGuuAuAcAGAcAcGAdTsdT sense 1685-1704
9982 UCGUGUCUGUAUAACUGAC 11982 UCGUGUCUGuAuAACUGACdTsdT antis
1687-1706 9983 CAGUUAUACAGACACGAAA 11983 cAGuuAuAcAGAcAcGAAAdTsdT
sense 1687-1706 9984 UUUCGUGUCUGUAUAACUG 11984
UUUCGUGUCUGuAuAACUGdTsdT antis 1689-1708 9985 GUUAUACAGACACGAAAGU
11985 GuuAuAcAGAcAcGAAAGudTsdT sense 1689-1708 9986
ACUUUCGUGUCUGUAUAAC 11986 ACUUUCGUGUCUGuAuAACdTsdT antis 1691-1710
9987 UAUACAGACACGAAAGUGA 11987 uAuAcAGAcAcGAAAGuGAdTsdT sense
1691-1710 9988 UCACUUUCGUGUCUGUAUA 11988 UcACUUUCGUGUCUGuAuAdTsdT
antis 1693-1712 9989 UACAGACACGAAAGUGAUU 11989
uAcAGAcAcGAAAGuGAuudTsdT sense 1693-1712 9990 AAUCACUUUCGUGUCUGUA
11990 AAUcACUUUCGUGUCUGuAdTsdT antis 1701-1720 9991
CGAAAGUGAUUGGAAAUGG 11991 cGAAAGuGAuuGGAAAuGGdTsdT sense 1701-1720
9992 CCAUUUCCAAUCACUUUCG 11992 CcAUUUCcAAUcACUUUCGdTsdT antis
1707-1726 9993 UGAUUGGAAAUGGAUCAUU 11993 uGAuuGGAAAuGGAucAuudTsdT
sense 1707-1726 9994 AAUGAUCCAUUUCCAAUCA 11994
AAUGAUCcAUUUCcAAUcAdTsdT antis 1717-1736 9995 UGGAUCAUUUGGUGUGGUA
11995 uGGAucAuuuGGuGuGGuAdTsdT sense 1717-1736 9996
UACCACACCAAAUGAUCCA 11996 uACcAcACcAAAUGAUCcAdTsdT antis 1721-1740
9997 UCAUUUGGUGUGGUAUAUC 11997 ucAuuuGGuGuGGuAuAucdTsdT sense
1721-1740 9998 GAUAUACCACACCAAAUGA 11998 GAuAuACcAcACcAAAUGAdTsdT
antis 1729-1748 9999 UGUGGUAUAUCAAGCCAAA 11999
uGuGGuAuAucAAGccAAAdTsdT sense 1729-1748 10000 UUUGGCUUGAUAUACCACA
12000 UUUGGCUUGAuAuACcAcAdTsdT antis 1734-1753 10001
UAUAUCAAGCCAAACUUUG 12001 uAuAucAAGccAAAcuuuGdTsdT sense 1734-1753
10002 CAAAGUUUGGCUUGAUAUA 12002 cAAAGUUUGGCUUGAuAuAdTsdT antis
1736-1755 10003 UAUCAAGCCAAACUUUGUG 12003 uAucAAGccAAAcuuuGuGdTsdT
sense 1736-1755 10004 CACAAAGUUUGGCUUGAUA 12004
cAcAAAGUUUGGCUUGAuAdTsdT antis 1737-1756 10005 AUCAAGCCAAACUUUGUGA
12005 AucAAGccAAAcuuuGuGAdTsdT sense 1737-1756 10006
UCACAAAGUUUGGCUUGAU 12006 UcAcAAAGUUUGGCUUGAUdTsdT antis 1749-1768
10007 UUUGUGAUUCUGGAGAACU 12007 uuuGuGAuucuGGAGAAcudTsdT sense
1749-1768 10008 AGUUCUCCAGAAUCACAAA 12008 AGUUCUCcAGAAUcAcAAAdTsdT
antis 1759-1778 10009 UGGAGAACUGGUUGCCAUC 12009
uGGAGAAcuGGuuGccAucdTsdT sense 1759-1778 10010 GAUGGCAACCAGUUCUCCA
12010 GAUGGcAACcAGUUCUCcAdTsdT antis 1760-1779 10011
GGAGAACUGGUUGCCAUCA 12011 GGAGAAcuGGuuGccAucAdTsdT sense 1760-1779
10012 UGAUGGCAACCAGUUCUCC 12012 UGAUGGcAACcAGUUCUCCdTsdT antis
1767-1786 10013 UGGUUGCCAUCAAGAAAGU 12013 uGGuuGccAucAAGAAAGudTsdT
sense 1767-1786 10014 ACUUUCUUGAUGGCAACCA 12014
ACUUUCUUGAUGGcAACcAdTsdT antis 1769-1788 10015 GUUGCCAUCAAGAAAGUUC
12015 GuuGccAucAAGAAAGuucdTsdT sense 1769-1788 10016
GAACUUUCUUGAUGGCAAC 12016 GAACUUUCUUGAUGGcAACdTsdT antis 1770-1789
10017 UUGCCAUCAAGAAAGUUCU 12017 uuGccAucAAGAAAGuucudTsdT sense
1770-1789 10018 AGAACUUUCUUGAUGGCAA 12018 AGAACUUUCUUGAUGGcAAdTsdT
antis 1775-1794 10019 AUCAAGAAAGUUCUACAGG 12019
AucAAGAAAGuucuAcAGGdTsdT sense 1775-1794 10020 CCUGUAGAACUUUCUUGAU
12020 CCUGuAGAACUUUCUUGAUdTsdT antis 1783-1802 10021
AGUUCUACAGGACAAGCGA 12021 AGuucuAcAGGAcAAGcGAdTsdT sense 1783-1802
10022 UCGCUUGUCCUGUAGAACU 12022 UCGCUUGUCCUGuAGAACUdTsdT antis
1787-1806 10023 CUACAGGACAAGCGAUUUA 12023 cuAcAGGAcAAGcGAuuuAdTsdT
sense 1787-1806 10024 UAAAUCGCUUGUCCUGUAG 12024
uAAAUCGCUUGUCCUGuAGdTsdT antis 1806-1825 10025 AGAACCGAGAGCUCCAGAU
12025 AGAAccGAGAGcuccAGAudTsdT sense 1806-1825 10026
AUCUGGAGCUCUCGGUUCU 12026 AUCUGGAGCUCUCGGUUCUdTsdT antis 1810-1829
10027 CCGAGAGCUCCAGAUCAUG 12027 ccGAGAGcuccAGAucAuGdTsdT sense
1810-1829 10028 CAUGAUCUGGAGCUCUCGG 12028 cAUGAUCUGGAGCUCUCGGdTsdT
antis 1815-1834 10029 AGCUCCAGAUCAUGAGAAA 12029
AGcuccAGAucAuGAGAAAdTsdT sense 1815-1834 10030 UUUCUCAUGAUCUGGAGCU
12030 UUUCUcAUGAUCUGGAGCUdTsdT antis 1816-1835 10031
GCUCCAGAUCAUGAGAAAG 12031 GcuccAGAucAuGAGAAAGdTsdT sense 1816-1835
10032 CUUUCUCAUGAUCUGGAGC 12032 CUUUCUcAUGAUCUGGAGCdTsdT antis
1817-1836 10033 CUCCAGAUCAUGAGAAAGC 12033 cuccAGAucAuGAGAAAGcdTsdT
sense 1817-1836 10034 GCUUUCUCAUGAUCUGGAG 12034
GCUUUCUcAUGAUCUGGAGdTsdT antis 1820-1839 10035 CAGAUCAUGAGAAAGCUAG
12035 cAGAucAuGAGAAAGcuAGdTsdT sense 1820-1839 10036
CUAGCUUUCUCAUGAUCUG 12036 CuAGCUUUCUcAUGAUCUGdTsdT antis 1824-1843
10037 UCAUGAGAAAGCUAGACCA 12037 ucAuGAGAAAGcuAGAccAdTsdT sense
1824-1843 10038 UGGUCUAGCUUUCUCAUGA 12038 UGGUCuAGCUUUCUcAUGAdTsdT
antis 1825-1844 10039 CAUGAGAAAGCUAGACCAC 12039
cAuGAGAAAGcuAGAccAcdTsdT sense 1825-1844 10040 GUGGUCUAGCUUUCUCAUG
12040 GUGGUCuAGCUUUCUcAUGdTsdT antis 1826-1845 10041
AUGAGAAAGCUAGACCACU 12041 AuGAGAAAGcuAGAccAcudTsdT sense 1826-1845
10042 AGUGGUCUAGCUUUCUCAU 12042 AGUGGUCuAGCUUUCUcAUdTsdT antis
1858-1877 10043 ACUGCGGUAUUUCUUCUAC 12043 AcuGcGGuAuuucuucuAcdTsdT
sense 1858-1877 10044 GUAGAAGAAAUACCGCAGU 12044
GuAGAAGAAAuACCGcAGUdTsdT antis 1866-1885 10045 AUUUCUUCUACUCGAGUGG
12045 AuuucuucuAcucGAGuGGdTsdT sense 1866-1885 10046
CCACUCGAGUAGAAGAAAU 12046 CcACUCGAGuAGAAGAAAUdTsdT antis 1869-1888
10047 UCUUCUACUCGAGUGGUGA 12047 ucuucuAcucGAGuGGuGAdTsdT sense
1869-1888 10048 UCACCACUCGAGUAGAAGA 12048 UcACcACUCGAGuAGAAGAdTsdT
antis 1878-1897 10049 CGAGUGGUGAGAAGAAAGA 12049
cGAGuGGuGAGAAGAAAGAdTsdT sense 1878-1897 10050 UCUUUCUUCUCACCACUCG
12050 UCUUUCUUCUcACcACUCGdTsdT antis 1890-1909 10051
AGAAAGAUGAGGUCUACCU 12051 AGAAAGAuGAGGucuAccudTsdT sense 1890-1909
10052 AGGUAGACCUCAUCUUUCU 12052 AGGuAGACCUcAUCUUUCUdTsdT antis
1891-1910 10053 GAAAGAUGAGGUCUACCUU 12053 GAAAGAuGAGGucuAccuudTsdT
sense 1891-1910 10054 AAGGUAGACCUCAUCUUUC 12054
AAGGuAGACCUcAUCUUUCdTsdT antis 1898-1917 10055 GAGGUCUACCUUAACCUGG
12055 GAGGucuAccuuAAccuGGdTsdT sense 1898-1917 10056
CCAGGUUAAGGUAGACCUC 12056 CcAGGUuAAGGuAGACCUCdTsdT antis 1903-1922
10057 CUACCUUAACCUGGUGCUG 12057 cuAccuuAAccuGGuGcuGdTsdT sense
1903-1922 10058 CAGCACCAGGUUAAGGUAG 12058 cAGcACcAGGUuAAGGuAGdTsdT
antis 1911-1930 10059 ACCUGGUGCUGGACUAUGU 12059
AccuGGuGcuGGAcuAuGudTsdT sense 1911-1930 10060 ACAUAGUCCAGCACCAGGU
12060 AcAuAGUCcAGcACcAGGUdTsdT antis 1912-1931 10061
CCUGGUGCUGGACUAUGUU 12061 ccuGGuGcuGGAcuAuGuudTsdT sense 1912-1931
10062 AACAUAGUCCAGCACCAGG 12062 AAcAuAGUCcAGcACcAGGdTsdT antis
1915-1934 10063 GGUGCUGGACUAUGUUCCG 12063 GGuGcuGGAcuAuGuuccGdTsdT
sense 1915-1934 10064 CGGAACAUAGUCCAGCACC 12064
CGGAAcAuAGUCcAGcACCdTsdT antis 1929-1948 10065 UUCCGGAGACAGUGUACAG
12065 uuccGGAGAcAGuGuAcAGdTsdT sense 1929-1948 10066
CUGUACACUGUCUCCGGAA 12066 CUGuAcACUGUCUCCGGAAdTsdT antis 1933-1952
10067 GGAGACAGUGUACAGAGUC 12067 GGAGAcAGuGuAcAGAGucdTsdT sense
1933-1952 10068 GACUCUGUACACUGUCUCC 12068 GACUCUGuAcACUGUCUCCdTsdT
antis 1935-1954 10069 AGACAGUGUACAGAGUCGC 12069
AGAcAGuGuAcAGAGucGcdTsdT sense 1935-1954 10070 GCGACUCUGUACACUGUCU
12070 GCGACUCUGuAcACUGUCUdTsdT antis 1941-1960 10071
UGUACAGAGUCGCCAGACA 12071 uGuAcAGAGucGccAGAcAdTsdT sense 1941-1960
10072 UGUCUGGCGACUCUGUACA 12072 UGUCUGGCGACUCUGuAcAdTsdT antis
1944-1963 10073 ACAGAGUCGCCAGACACUA 12073 AcAGAGucGccAGAcAcuAdTsdT
sense 1944-1963 10074 UAGUGUCUGGCGACUCUGU 12074
uAGUGUCUGGCGACUCUGUdTsdT antis 1945-1964 10075 CAGAGUCGCCAGACACUAU
12075 cAGAGucGccAGAcAcuAudTsdT sense 1945-1964 10076
AUAGUGUCUGGCGACUCUG 12076 AuAGUGUCUGGCGACUCUGdTsdT antis 1965-1984
10077 GUCGAGCCAAGCAGACACU 12077 GucGAGccAAGcAGAcAcudTsdT sense
1965-1984 10078 AGUGUCUGCUUGGCUCGAC 12078 AGUGUCUGCUUGGCUCGACdTsdT
antis 1966-1985 10079 UCGAGCCAAGCAGACACUC 12079
ucGAGccAAGcAGAcAcucdTsdT sense 1966-1985 10080 GAGUGUCUGCUUGGCUCGA
12080 GAGUGUCUGCUUGGCUCGAdTsdT antis 1967-1986 10081
CGAGCCAAGCAGACACUCC 12081 cGAGccAAGcAGAcAcuccdTsdT sense 1967-1986
10082 GGAGUGUCUGCUUGGCUCG 12082 GGAGUGUCUGCUUGGCUCGdTsdT antis
1970-1989 10083 GCCAAGCAGACACUCCCUG 12083 GccAAGcAGAcAcucccuGdTsdT
sense 1970-1989 10084 CAGGGAGUGUCUGCUUGGC 12084
cAGGGAGUGUCUGCUUGGCdTsdT antis 1971-1990 10085 CCAAGCAGACACUCCCUGU
12085 ccAAGcAGAcAcucccuGudTsdT sense 1971-1990 10086
ACAGGGAGUGUCUGCUUGG 12086 AcAGGGAGUGUCUGCUUGGdTsdT antis 1974-1993
10087 AGCAGACACUCCCUGUGAU 12087 AGcAGAcAcucccuGuGAudTsdT sense
1974-1993 10088 AUCACAGGGAGUGUCUGCU 12088 AUcAcAGGGAGUGUCUGCUdTsdT
antis 1975-1994 10089 GCAGACACUCCCUGUGAUC 12089
GcAGAcAcucccuGuGAucdTsdT sense 1975-1994 10090 GAUCACAGGGAGUGUCUGC
12090 GAUcAcAGGGAGUGUCUGCdTsdT antis 1986-2005 10091
CUGUGAUCUAUGUCAAGUU 12091 cuGuGAucuAuGucAAGuudTsdT sense 1986-2005
10092 AACUUGACAUAGAUCACAG 12092 AACUUGAcAuAGAUcAcAGdTsdT antis
1993-2012 10093 CUAUGUCAAGUUGUAUAUG 12093 cuAuGucAAGuuGuAuAuGdTsdT
sense 1993-2012 10094 CAUAUACAACUUGACAUAG 12094
cAuAuAcAACUUGAcAuAGdTsdT antis 1995-2014 10095 AUGUCAAGUUGUAUAUGUA
12095 AuGucAAGuuGuAuAuGuAdTsdT sense 1995-2014 10096
UACAUAUACAACUUGACAU 12096 uAcAuAuAcAACUUGAcAUdTsdT antis 1996-2015
10097 UGUCAAGUUGUAUAUGUAU 12097 uGucAAGuuGuAuAuGuAudTsdT sense
1996-2015 10098 AUACAUAUACAACUUGACA 12098 AuAcAuAuAcAACUUGAcAdTsdT
antis 1999-2018 10099 CAAGUUGUAUAUGUAUCAG 12099
cAAGuuGuAuAuGuAucAGdTsdT sense 1999-2018 10100 CUGAUACAUAUACAACUUG
12100 CUGAuAcAuAuAcAACUUGdTsdT antis 2009-2028 10101
AUGUAUCAGCUGUUCAGAA 12101 AuGuAucAGcuGuucAGAAdTsdT sense 2009-2028
10102 UUCUGAACAGCUGAUACAU 12102 UUCUGAAcAGCUGAuAcAUdTsdT antis
2010-2029 10103 UGUAUCAGCUGUUCAGAAG 12103 uGuAucAGcuGuucAGAAGdTsdT
sense 2010-2029 10104 CUUCUGAACAGCUGAUACA 12104
CUUCUGAAcAGCUGAuAcAdTsdT antis 2016-2035 10105 AGCUGUUCAGAAGUCUAGC
12105 AGcuGuucAGAAGucuAGcdTsdT sense 2016-2035 10106
GCUAGACUUCUGAACAGCU 12106 GCuAGACUUCUGAAcAGCUdTsdT antis 2035-2054
10107 CUAUAUCCAUUCCUUUGGA 12107 cuAuAuccAuuccuuuGGAdTsdT sense
2035-2054 10108 UCCAAAGGAAUGGAUAUAG 12108 UCcAAAGGAAUGGAuAuAGdTsdT
antis
2036-2055 10109 UAUAUCCAUUCCUUUGGAA 12109 uAuAuccAuuccuuuGGAAdTsdT
sense 2036-2055 10110 UUCCAAAGGAAUGGAUAUA 12110
UUCcAAAGGAAUGGAuAuAdTsdT antis 2046-2065 10111 CCUUUGGAAUCUGCCAUCG
12111 ccuuuGGAAucuGccAucGdTsdT sense 2046-2065 10112
CGAUGGCAGAUUCCAAAGG 12112 CGAUGGcAGAUUCcAAAGGdTsdT antis 2049-2068
10113 UUGGAAUCUGCCAUCGAGA 12113 uuGGAAucuGccAucGAGAdTsdT sense
2049-2068 10114 UCUCGAUGGCAGAUUCCAA 12114 UCUCGAUGGcAGAUUCcAAdTsdT
antis 2051-2070 10115 GGAAUCUGCCAUCGAGACA 12115
GGAAucuGccAucGAGAcAdTsdT sense 2051-2070 10116 UGUCUCGAUGGCAGAUUCC
12116 UGUCUCGAUGGcAGAUUCCdTsdT antis 2068-2087 10117
CAUUAAACCACAGAACCUC 12117 cAuuAAAccAcAGAAccucdTsdT sense 2068-2087
10118 GAGGUUCUGUGGUUUAAUG 12118 GAGGUUCUGUGGUUuAAUGdTsdT antis
2070-2089 10119 UUAAACCACAGAACCUCUU 12119 uuAAAccAcAGAAccucuudTsdT
sense 2070-2089 10120 AAGAGGUUCUGUGGUUUAA 12120
AAGAGGUUCUGUGGUUuAAdTsdT antis 2071-2090 10121 UAAACCACAGAACCUCUUG
12121 uAAAccAcAGAAccucuuGdTsdT sense 2071-2090 10122
CAAGAGGUUCUGUGGUUUA 12122 cAAGAGGUUCUGUGGUUuAdTsdT antis 2073-2092
10123 AACCACAGAACCUCUUGUU 12123 AAccAcAGAAccucuuGuudTsdT sense
2073-2092 10124 AACAAGAGGUUCUGUGGUU 12124 AAcAAGAGGUUCUGUGGUUdTsdT
antis 2075-2094 10125 CCACAGAACCUCUUGUUGG 12125
ccAcAGAAccucuuGuuGGdTsdT sense 2075-2094 10126 CCAACAAGAGGUUCUGUGG
12126 CcAAcAAGAGGUUCUGUGGdTsdT antis 2076-2095 10127
CACAGAACCUCUUGUUGGA 12127 cAcAGAAccucuuGuuGGAdTsdT sense 2076-2095
10128 UCCAACAAGAGGUUCUGUG 12128 UCcAAcAAGAGGUUCUGUGdTsdT antis
2078-2097 10129 CAGAACCUCUUGUUGGAUC 12129 cAGAAccucuuGuuGGAucdTsdT
sense 2078-2097 10130 GAUCCAACAAGAGGUUCUG 12130
GAUCcAAcAAGAGGUUCUGdTsdT antis 2084-2103 10131 CUCUUGUUGGAUCCUGAUA
12131 cucuuGuuGGAuccuGAuAdTsdT sense 2084-2103 10132
UAUCAGGAUCCAACAAGAG 12132 uAUcAGGAUCcAAcAAGAGdTsdT antis 2086-2105
10133 CUUGUUGGAUCCUGAUACA 12133 cuuGuuGGAuccuGAuAcAdTsdT sense
2086-2105 10134 UGUAUCAGGAUCCAACAAG 12134 UGuAUcAGGAUCcAAcAAGdTsdT
antis 2095-2114 10135 UCCUGAUACAGCUGUAUUA 12135
uccuGAuAcAGcuGuAuuAdTsdT sense 2095-2114 10136 UAAUACAGCUGUAUCAGGA
12136 uAAuAcAGCUGuAUcAGGAdTsdT antis 2102-2121 10137
ACAGCUGUAUUAAAACUCU 12137 AcAGcuGuAuuAAAAcucudTsdT sense 2102-2121
10138 AGAGUUUUAAUACAGCUGU 12138 AGAGUUUuAAuAcAGCUGUdTsdT antis
2103-2122 10139 CAGCUGUAUUAAAACUCUG 12139 cAGcuGuAuuAAAAcucuGdTsdT
sense 2103-2122 10140 CAGAGUUUUAAUACAGCUG 12140
cAGAGUUUuAAuAcAGCUGdTsdT antis 2105-2124 10141 GCUGUAUUAAAACUCUGUG
12141 GcuGuAuuAAAAcucuGuGdTsdT sense 2105-2124 10142
CACAGAGUUUUAAUACAGC 12142 cAcAGAGUUUuAAuAcAGCdTsdT antis 2106-2125
10143 CUGUAUUAAAACUCUGUGA 12143 cuGuAuuAAAAcucuGuGAdTsdT sense
2106-2125 10144 UCACAGAGUUUUAAUACAG 12144 UcAcAGAGUUUuAAuAcAGdTsdT
antis 2108-2127 10145 GUAUUAAAACUCUGUGACU 12145
GuAuuAAAAcucuGuGAcudTsdT sense 2108-2127 10146 AGUCACAGAGUUUUAAUAC
12146 AGUcAcAGAGUUUuAAuACdTsdT antis 2115-2134 10147
AACUCUGUGACUUUGGAAG 12147 AAcucuGuGAcuuuGGAAGdTsdT sense 2115-2134
10148 CUUCCAAAGUCACAGAGUU 12148 CUUCcAAAGUcAcAGAGUUdTsdT antis
2120-2139 10149 UGUGACUUUGGAAGUGCAA 12149 uGuGAcuuuGGAAGuGcAAdTsdT
sense 2120-2139 10150 UUGCACUUCCAAAGUCACA 12150
UUGcACUUCcAAAGUcAcAdTsdT antis 2124-2143 10151 ACUUUGGAAGUGCAAAGCA
12151 AcuuuGGAAGuGcAAAGcAdTsdT sense 2124-2143 10152
UGCUUUGCACUUCCAAAGU 12152 UGCUUUGcACUUCcAAAGUdTsdT antis 2132-2151
10153 AGUGCAAAGCAGCUGGUCC 12153 AGuGcAAAGcAGcuGGuccdTsdT sense
2132-2151 10154 GGACCAGCUGCUUUGCACU 12154 GGACcAGCUGCUUUGcACUdTsdT
antis 2134-2153 10155 UGCAAAGCAGCUGGUCCGA 12155
uGcAAAGcAGcuGGuccGAdTsdT sense 2134-2153 10156 UCGGACCAGCUGCUUUGCA
12156 UCGGACcAGCUGCUUUGcAdTsdT antis 2136-2155 10157
CAAAGCAGCUGGUCCGAGG 12157 cAAAGcAGcuGGuccGAGGdTsdT sense 2136-2155
10158 CCUCGGACCAGCUGCUUUG 12158 CCUCGGACcAGCUGCUUUGdTsdT antis
2139-2158 10159 AGCAGCUGGUCCGAGGAGA 12159 AGcAGcuGGuccGAGGAGAdTsdT
sense 2139-2158 10160 UCUCCUCGGACCAGCUGCU 12160
UCUCCUCGGACcAGCUGCUdTsdT antis 2140-2159 10161 GCAGCUGGUCCGAGGAGAG
12161 GcAGcuGGuccGAGGAGAGdTsdT sense 2140-2159 10162
CUCUCCUCGGACCAGCUGC 12162 CUCUCCUCGGACcAGCUGCdTsdT antis 2141-2160
10163 CAGCUGGUCCGAGGAGAGC 12163 cAGcuGGuccGAGGAGAGcdTsdT sense
2141-2160 10164 GCUCUCCUCGGACCAGCUG 12164 GCUCUCCUCGGACcAGCUGdTsdT
antis 2142-2161 10165 AGCUGGUCCGAGGAGAGCC 12165
AGcuGGuccGAGGAGAGccdTsdT sense 2142-2161 10166 GGCUCUCCUCGGACCAGCU
12166 GGCUCUCCUCGGACcAGCUdTsdT antis 2146-2165 10167
GGUCCGAGGAGAGCCCAAU 12167 GGuccGAGGAGAGcccAAudTsdT sense 2146-2165
10168 AUUGGGCUCUCCUCGGACC 12168 AUUGGGCUCUCCUCGGACCdTsdT antis
2147-2166 10169 GUCCGAGGAGAGCCCAAUG 12169 GuccGAGGAGAGcccAAuGdTsdT
sense 2147-2166 10170 CAUUGGGCUCUCCUCGGAC 12170
cAUUGGGCUCUCCUCGGACdTsdT antis 2160-2179 10171 CCAAUGUUUCAUAUAUCUG
12171 ccAAuGuuucAuAuAucuGdTsdT sense 2160-2179 10172
CAGAUAUAUGAAACAUUGG 12172 cAGAuAuAUGAAAcAUUGGdTsdT antis 2189-2208
10173 UACAGGGCACCAGAGUUGA 12173 uAcAGGGcAccAGAGuuGAdTsdT sense
2189-2208 10174 UCAACUCUGGUGCCCUGUA 12174 UcAACUCUGGUGCCCUGuAdTsdT
antis 2191-2210 10175 CAGGGCACCAGAGUUGAUC 12175
cAGGGcAccAGAGuuGAucdTsdT sense 2191-2210 10176 GAUCAACUCUGGUGCCCUG
12176 GAUcAACUCUGGUGCCCUGdTsdT antis 2194-2213 10177
GGCACCAGAGUUGAUCUUU 12177 GGcAccAGAGuuGAucuuudTsdT sense 2194-2213
10178 AAAGAUCAACUCUGGUGCC 12178 AAAGAUcAACUCUGGUGCCdTsdT antis
2195-2214 10179 GCACCAGAGUUGAUCUUUG 12179 GcAccAGAGuuGAucuuuGdTsdT
sense 2195-2214 10180 CAAAGAUCAACUCUGGUGC 12180
cAAAGAUcAACUCUGGUGCdTsdT antis 2196-2215 10181 CACCAGAGUUGAUCUUUGG
12181 cAccAGAGuuGAucuuuGGdTsdT sense 2196-2215 10182
CCAAAGAUCAACUCUGGUG 12182 CcAAAGAUcAACUCUGGUGdTsdT antis 2201-2220
10183 GAGUUGAUCUUUGGAGCCA 12183 GAGuuGAucuuuGGAGccAdTsdT sense
2201-2220 10184 UGGCUCCAAAGAUCAACUC 12184 UGGCUCcAAAGAUcAACUCdTsdT
antis 2211-2230 10185 UUGGAGCCACUGAUUACAC 12185
uuGGAGccAcuGAuuAcAcdTsdT sense 2211-2230 10186 GUGUAAUCAGUGGCUCCAA
12186 GUGuAAUcAGUGGCUCcAAdTsdT antis 2234-2253 10187
AGUAUAGAUGUAUGGUCUG 12187 AGuAuAGAuGuAuGGucuGdTsdT sense 2234-2253
10188 CAGACCAUACAUCUAUACU 12188 cAGACcAuAcAUCuAuACUdTsdT antis
2238-2257 10189 UAGAUGUAUGGUCUGCAGG 12189 uAGAuGuAuGGucuGcAGGdTsdT
sense 2238-2257 10190 CCUGCAGACCAUACAUCUA 12190
CCUGcAGACcAuAcAUCuAdTsdT antis 2240-2259 10191 GAUGUAUGGUCUGCAGGCU
12191 GAuGuAuGGucuGcAGGcudTsdT sense 2240-2259 10192
AGCCUGCAGACCAUACAUC 12192 AGCCUGcAGACcAuAcAUCdTsdT antis 2241-2260
10193 AUGUAUGGUCUGCAGGCUG 12193 AuGuAuGGucuGcAGGcuGdTsdT sense
2241-2260 10194 CAGCCUGCAGACCAUACAU 12194 cAGCCUGcAGACcAuAcAUdTsdT
antis 2242-2261 10195 UGUAUGGUCUGCAGGCUGU 12195
uGuAuGGucuGcAGGcuGudTsdT sense 2242-2261 10196 ACAGCCUGCAGACCAUACA
12196 AcAGCCUGcAGACcAuAcAdTsdT antis 2249-2268 10197
UCUGCAGGCUGUGUGUUGG 12197 ucuGcAGGcuGuGuGuuGGdTsdT sense 2249-2268
10198 CCAACACACAGCCUGCAGA 12198 CcAAcAcAcAGCCUGcAGAdTsdT antis
2255-2274 10199 GGCUGUGUGUUGGCUGAAU 12199 GGcuGuGuGuuGGcuGAAudTsdT
sense 2255-2274 10200 AUUCAGCCAACACACAGCC 12200
AUUcAGCcAAcAcAcAGCCdTsdT antis 2256-2275 10201 GCUGUGUGUUGGCUGAAUU
12201 GcuGuGuGuuGGcuGAAuudTsdT sense 2256-2275 10202
AAUUCAGCCAACACACAGC 12202 AAUUcAGCcAAcAcAcAGCdTsdT antis 2257-2276
10203 CUGUGUGUUGGCUGAAUUG 12203 cuGuGuGuuGGcuGAAuuGdTsdT sense
2257-2276 10204 CAAUUCAGCCAACACACAG 12204 cAAUUcAGCcAAcAcAcAGdTsdT
antis 2259-2278 10205 GUGUGUUGGCUGAAUUGUU 12205
GuGuGuuGGcuGAAuuGuudTsdT sense 2259-2278 10206 AACAAUUCAGCCAACACAC
12206 AAcAAUUcAGCcAAcAcACdTsdT antis 2260-2279 10207
UGUGUUGGCUGAAUUGUUG 12207 uGuGuuGGcuGAAuuGuuGdTsdT sense 2260-2279
10208 CAACAAUUCAGCCAACACA 12208 cAAcAAUUcAGCcAAcAcAdTsdT antis
2271-2290 10209 AAUUGUUGCUAGGACAACC 12209 AAuuGuuGcuAGGAcAAccdTsdT
sense 2271-2290 10210 GGUUGUCCUAGCAACAAUU 12210
GGUUGUCCuAGcAAcAAUUdTsdT antis 2280-2299 10211 UAGGACAACCAAUAUUUCC
12211 uAGGAcAAccAAuAuuuccdTsdT sense 2280-2299 10212
GGAAAUAUUGGUUGUCCUA 12212 GGAAAuAUUGGUUGUCCuAdTsdT antis 2284-2303
10213 ACAACCAAUAUUUCCUGGG 12213 AcAAccAAuAuuuccuGGGdTsdT sense
2284-2303 10214 CCCAGGAAAUAUUGGUUGU 12214 CCcAGGAAAuAUUGGUUGUdTsdT
antis 2287-2306 10215 ACCAAUAUUUCCUGGGGAC 12215
AccAAuAuuuccuGGGGAcdTsdT sense 2287-2306 10216 GUCCCCAGGAAAUAUUGGU
12216 GUCCCcAGGAAAuAUUGGUdTsdT antis 2288-2307 10217
CCAAUAUUUCCUGGGGACA 12217 ccAAuAuuuccuGGGGAcAdTsdT sense 2288-2307
10218 UGUCCCCAGGAAAUAUUGG 12218 UGUCCCcAGGAAAuAUUGGdTsdT antis
2289-2308 10219 CAAUAUUUCCUGGGGACAG 12219 cAAuAuuuccuGGGGAcAGdTsdT
sense 2289-2308 10220 CUGUCCCCAGGAAAUAUUG 12220
CUGUCCCcAGGAAAuAUUGdTsdT antis 2290-2309 10221 AAUAUUUCCUGGGGACAGU
12221 AAuAuuuccuGGGGAcAGudTsdT sense 2290-2309 10222
ACUGUCCCCAGGAAAUAUU 12222 ACUGUCCCcAGGAAAuAUUdTsdT antis 2292-2311
10223 UAUUUCCUGGGGACAGUGG 12223 uAuuuccuGGGGAcAGuGGdTsdT sense
2292-2311 10224 CCACUGUCCCCAGGAAAUA 12224 CcACUGUCCCcAGGAAAuAdTsdT
antis 2299-2318 10225 UGGGGACAGUGGUGUGGAU 12225
uGGGGAcAGuGGuGuGGAudTsdT sense 2299-2318 10226 AUCCACACCACUGUCCCCA
12226 AUCcAcACcACUGUCCCcAdTsdT antis 2303-2322 10227
GACAGUGGUGUGGAUCAGU 12227 GAcAGuGGuGuGGAucAGudTsdT sense 2303-2322
10228 ACUGAUCCACACCACUGUC 12228 ACUGAUCcAcACcACUGUCdTsdT antis
2310-2329 10229 GUGUGGAUCAGUUGGUGGA 12229 GuGuGGAucAGuuGGuGGAdTsdT
sense 2310-2329 10230 UCCACCAACUGAUCCACAC 12230
UCcACcAACUGAUCcAcACdTsdT antis 2316-2335 10231 AUCAGUUGGUGGAAAUAAU
12231 AucAGuuGGuGGAAAuAAudTsdT sense 2316-2335 10232
AUUAUUUCCACCAACUGAU 12232 AUuAUUUCcACcAACUGAUdTsdT antis 2324-2343
10233 GUGGAAAUAAUAAAGGUCC 12233 GuGGAAAuAAuAAAGGuccdTsdT sense
2324-2343 10234 GGACCUUUAUUAUUUCCAC 12234 GGACCUUuAUuAUUUCcACdTsdT
antis 2327-2346 10235 GAAAUAAUAAAGGUCCUAG 12235
GAAAuAAuAAAGGuccuAGdTsdT sense 2327-2346 10236 CUAGGACCUUUAUUAUUUC
12236 CuAGGACCUUuAUuAUUUCdTsdT antis 2333-2352 10237
AUAAAGGUCCUAGGAACAC 12237 AuAAAGGuccuAGGAAcAcdTsdT sense 2333-2352
10238 GUGUUCCUAGGACCUUUAU 12238 GUGUUCCuAGGACCUUuAUdTsdT antis
2335-2354 10239 AAAGGUCCUAGGAACACCA 12239 AAAGGuccuAGGAAcAccAdTsdT
sense 2335-2354 10240 UGGUGUUCCUAGGACCUUU 12240
UGGUGUUCCuAGGACCUUUdTsdT antis 2341-2360 10241 CCUAGGAACACCAACAAGG
12241 ccuAGGAAcAccAAcAAGGdTsdT sense 2341-2360 10242
CCUUGUUGGUGUUCCUAGG 12242 CCUUGUUGGUGUUCCuAGGdTsdT antis 2345-2364
10243 GGAACACCAACAAGGGAGC 12243 GGAAcAccAAcAAGGGAGcdTsdT sense
2345-2364 10244 GCUCCCUUGUUGGUGUUCC 12244 GCUCCCUUGUUGGUGUUCCdTsdT
antis 2356-2375 10245 AAGGGAGCAAAUUAGAGAA 12245
AAGGGAGcAAAuuAGAGAAdTsdT sense 2356-2375 10246 UUCUCUAAUUUGCUCCCUU
12246 UUCUCuAAUUUGCUCCCUUdTsdT antis 2358-2377 10247
GGGAGCAAAUUAGAGAAAU 12247 GGGAGcAAAuuAGAGAAAudTsdT sense 2358-2377
10248 AUUUCUCUAAUUUGCUCCC 12248 AUUUCUCuAAUUUGCUCCCdTsdT antis
2364-2383 10249 AAAUUAGAGAAAUGAACCC 12249 AAAuuAGAGAAAuGAAcccdTsdT
sense 2364-2383 10250 GGGUUCAUUUCUCUAAUUU 12250
GGGUUcAUUUCUCuAAUUUdTsdT antis 2365-2384 10251 AAUUAGAGAAAUGAACCCA
12251 AAuuAGAGAAAuGAAcccAdTsdT sense 2365-2384 10252
UGGGUUCAUUUCUCUAAUU 12252 UGGGUUcAUUUCUCuAAUUdTsdT antis 2368-2387
10253 UAGAGAAAUGAACCCAAAU 12253 uAGAGAAAuGAAcccAAAudTsdT sense
2368-2387 10254 AUUUGGGUUCAUUUCUCUA 12254 AUUUGGGUUcAUUUCUCuAdTsdT
antis 2369-2388 10255 AGAGAAAUGAACCCAAAUU 12255
AGAGAAAuGAAcccAAAuudTsdT sense 2369-2388 10256 AAUUUGGGUUCAUUUCUCU
12256 AAUUUGGGUUcAUUUCUCUdTsdT antis 2371-2390 10257
AGAAAUGAACCCAAAUUAU 12257 AGAAAuGAAcccAAAuuAudTsdT sense 2371-2390
10258 AUAAUUUGGGUUCAUUUCU 12258 AuAAUUUGGGUUcAUUUCUdTsdT antis
2372-2391 10259 GAAAUGAACCCAAAUUAUA 12259 GAAAuGAAcccAAAuuAuAdTsdT
sense 2372-2391 10260 UAUAAUUUGGGUUCAUUUC 12260
uAuAAUUUGGGUUcAUUUCdTsdT antis 2374-2393 10261 AAUGAACCCAAAUUAUACA
12261 AAuGAAcccAAAuuAuAcAdTsdT sense 2374-2393 10262
UGUAUAAUUUGGGUUCAUU 12262 UGuAuAAUUUGGGUUcAUUdTsdT antis 2375-2394
10263 AUGAACCCAAAUUAUACAG 12263 AuGAAcccAAAuuAuAcAGdTsdT sense
2375-2394 10264 CUGUAUAAUUUGGGUUCAU 12264 CUGuAuAAUUUGGGUUcAUdTsdT
antis 2381-2400 10265 CCAAAUUAUACAGAAUUCA 12265
ccAAAuuAuAcAGAAuucAdTsdT sense 2381-2400 10266 UGAAUUCUGUAUAAUUUGG
12266 UGAAUUCUGuAuAAUUUGGdTsdT antis 2386-2405 10267
UUAUACAGAAUUCAAAUUC 12267 uuAuAcAGAAuucAAAuucdTsdT sense 2386-2405
10268 GAAUUUGAAUUCUGUAUAA 12268 GAAUUUGAAUUCUGuAuAAdTsdT antis
2387-2406 10269 UAUACAGAAUUCAAAUUCC 12269 uAuAcAGAAuucAAAuuccdTsdT
sense 2387-2406 10270 GGAAUUUGAAUUCUGUAUA 12270
GGAAUUUGAAUUCUGuAuAdTsdT antis 2388-2407 10271 AUACAGAAUUCAAAUUCCC
12271 AuAcAGAAuucAAAuucccdTsdT sense 2388-2407 10272
GGGAAUUUGAAUUCUGUAU 12272 GGGAAUUUGAAUUCUGuAUdTsdT antis 2396-2415
10273 UUCAAAUUCCCUCAAAUCA 12273 uucAAAuucccucAAAucAdTsdT sense
2396-2415 10274 UGAUUUGAGGGAAUUUGAA 12274 UGAUUUGAGGGAAUUUGAAdTsdT
antis 2398-2417 10275 CAAAUUCCCUCAAAUCAAG 12275
cAAAuucccucAAAucAAGdTsdT sense 2398-2417 10276 CUUGAUUUGAGGGAAUUUG
12276 CUUGAUUUGAGGGAAUUUGdTsdT antis 2399-2418 10277
AAAUUCCCUCAAAUCAAGG 12277 AAAuucccucAAAucAAGGdTsdT sense 2399-2418
10278 CCUUGAUUUGAGGGAAUUU 12278 CCUUGAUUUGAGGGAAUUUdTsdT antis
2406-2425 10279 CUCAAAUCAAGGCACAUCC 12279 cucAAAucAAGGcAcAuccdTsdT
sense 2406-2425 10280 GGAUGUGCCUUGAUUUGAG 12280
GGAUGUGCCUUGAUUUGAGdTsdT antis 2407-2426 10281 UCAAAUCAAGGCACAUCCU
12281 ucAAAucAAGGcAcAuccudTsdT sense 2407-2426 10282
AGGAUGUGCCUUGAUUUGA 12282 AGGAUGUGCCUUGAUUUGAdTsdT antis 2410-2429
10283 AAUCAAGGCACAUCCUUGG 12283 AAucAAGGcAcAuccuuGGdTsdT sense
2410-2429 10284 CCAAGGAUGUGCCUUGAUU 12284 CcAAGGAUGUGCCUUGAUUdTsdT
antis 2411-2430 10285 AUCAAGGCACAUCCUUGGA 12285
AucAAGGcAcAuccuuGGAdTsdT sense 2411-2430 10286 UCCAAGGAUGUGCCUUGAU
12286 UCcAAGGAUGUGCCUUGAUdTsdT antis 2413-2432 10287
CAAGGCACAUCCUUGGACA 12287 cAAGGcAcAuccuuGGAcAdTsdT sense 2413-2432
10288 UGUCCAAGGAUGUGCCUUG 12288 UGUCcAAGGAUGUGCCUUGdTsdT antis
2415-2434 10289 AGGCACAUCCUUGGACAAA 12289 AGGcAcAuccuuGGAcAAAdTsdT
sense 2415-2434 10290 UUUGUCCAAGGAUGUGCCU 12290
UUUGUCcAAGGAUGUGCCUdTsdT antis 2416-2435 10291 GGCACAUCCUUGGACAAAG
12291 GGcAcAuccuuGGAcAAAGdTsdT sense 2416-2435 10292
CUUUGUCCAAGGAUGUGCC 12292 CUUUGUCcAAGGAUGUGCCdTsdT antis 2417-2436
10293 GCACAUCCUUGGACAAAGG 12293 GcAcAuccuuGGAcAAAGGdTsdT sense
2417-2436 10294 CCUUUGUCCAAGGAUGUGC 12294 CCUUUGUCcAAGGAUGUGCdTsdT
antis 2418-2437 10295 CACAUCCUUGGACAAAGGU 12295
cAcAuccuuGGAcAAAGGudTsdT sense 2418-2437 10296 ACCUUUGUCCAAGGAUGUG
12296 ACCUUUGUCcAAGGAUGUGdTsdT antis 2420-2439 10297
CAUCCUUGGACAAAGGUCU 12297 cAuccuuGGAcAAAGGucudTsdT sense 2420-2439
10298 AGACCUUUGUCCAAGGAUG 12298 AGACCUUUGUCcAAGGAUGdTsdT antis
2422-2441 10299 UCCUUGGACAAAGGUCUUC 12299 uccuuGGAcAAAGGucuucdTsdT
sense 2422-2441 10300 GAAGACCUUUGUCCAAGGA 12300
GAAGACCUUUGUCcAAGGAdTsdT antis 2426-2445 10301 UGGACAAAGGUCUUCCGGC
12301 uGGAcAAAGGucuuccGGcdTsdT sense 2426-2445 10302
GCCGGAAGACCUUUGUCCA 12302 GCCGGAAGACCUUUGUCcAdTsdT antis 2430-2449
10303 CAAAGGUCUUCCGGCCCCG 12303 cAAAGGucuuccGGccccGdTsdT sense
2430-2449 10304 CGGGGCCGGAAGACCUUUG 12304 CGGGGCCGGAAGACCUUUGdTsdT
antis 2439-2458 10305 UCCGGCCCCGAACUCCACC 12305
uccGGccccGAAcuccAccdTsdT sense 2439-2458 10306 GGUGGAGUUCGGGGCCGGA
12306 GGUGGAGUUCGGGGCCGGAdTsdT antis 2443-2462 10307
GCCCCGAACUCCACCAGAG 12307 GccccGAAcuccAccAGAGdTsdT sense 2443-2462
10308 CUCUGGUGGAGUUCGGGGC 12308 CUCUGGUGGAGUUCGGGGCdTsdT antis
2444-2463 10309 CCCCGAACUCCACCAGAGG 12309 ccccGAAcuccAccAGAGGdTsdT
sense 2444-2463 10310 CCUCUGGUGGAGUUCGGGG 12310
CCUCUGGUGGAGUUCGGGGdTsdT antis 2446-2465 10311 CCGAACUCCACCAGAGGCA
12311 ccGAAcuccAccAGAGGcAdTsdT sense 2446-2465 10312
UGCCUCUGGUGGAGUUCGG 12312 UGCCUCUGGUGGAGUUCGGdTsdT antis 2447-2466
10313 CGAACUCCACCAGAGGCAA 12313 cGAAcuccAccAGAGGcAAdTsdT sense
2447-2466 10314 UUGCCUCUGGUGGAGUUCG 12314 UUGCCUCUGGUGGAGUUCGdTsdT
antis 2448-2467 10315 GAACUCCACCAGAGGCAAU 12315
GAAcuccAccAGAGGcAAudTsdT sense 2448-2467 10316 AUUGCCUCUGGUGGAGUUC
12316 AUUGCCUCUGGUGGAGUUCdTsdT antis 2458-2477 10317
AGAGGCAAUUGCACUGUGC 12317 AGAGGcAAuuGcAcuGuGcdTsdT sense 2458-2477
10318 GCACAGUGCAAUUGCCUCU 12318 GcAcAGUGcAAUUGCCUCUdTsdT antis
2459-2478 10319 GAGGCAAUUGCACUGUGCA 12319 GAGGcAAuuGcAcuGuGcAdTsdT
sense 2459-2478 10320 UGCACAGUGCAAUUGCCUC 12320
UGcAcAGUGcAAUUGCCUCdTsdT antis 2461-2480 10321 GGCAAUUGCACUGUGCAGC
12321 GGcAAuuGcAcuGuGcAGcdTsdT sense 2461-2480 10322
GCUGCACAGUGCAAUUGCC 12322 GCUGcAcAGUGcAAUUGCCdTsdT antis 2462-2481
10323 GCAAUUGCACUGUGCAGCC 12323 GcAAuuGcAcuGuGcAGccdTsdT sense
2462-2481 10324 GGCUGCACAGUGCAAUUGC 12324 GGCUGcAcAGUGcAAUUGCdTsdT
antis 2464-2483 10325 AAUUGCACUGUGCAGCCGU 12325
AAuuGcAcuGuGcAGccGudTsdT sense 2464-2483 10326 ACGGCUGCACAGUGCAAUU
12326 ACGGCUGcAcAGUGcAAUUdTsdT antis 2465-2484 10327
AUUGCACUGUGCAGCCGUC 12327 AuuGcAcuGuGcAGccGucdTsdT sense 2465-2484
10328 GACGGCUGCACAGUGCAAU 12328 GACGGCUGcAcAGUGcAAUdTsdT antis
2471-2490 10329 CUGUGCAGCCGUCUGCUGG 12329 cuGuGcAGccGucuGcuGGdTsdT
sense 2471-2490 10330 CCAGCAGACGGCUGCACAG 12330
CcAGcAGACGGCUGcAcAGdTsdT antis 2485-2504 10331 GCUGGAGUACACACCUACC
12331 GcuGGAGuAcAcAccuAccdTsdT sense 2485-2504 10332
GGUAGGUGUGUACUCCAGC 12332 GGuAGGUGUGuACUCcAGCdTsdT antis 2507-2526
10333 CGGCUAACACCACUGGAAG 12333 cGGcuAAcAccAcuGGAAGdTsdT sense
2507-2526 10334 CUUCCAGUGGUGUUAGCCG 12334 CUUCcAGUGGUGUuAGCCGdTsdT
antis 2509-2528 10335 GCUAACACCACUGGAAGCU 12335
GcuAAcAccAcuGGAAGcudTsdT sense 2509-2528 10336 AGCUUCCAGUGGUGUUAGC
12336 AGCUUCcAGUGGUGUuAGCdTsdT antis 2510-2529 10337
CUAACACCACUGGAAGCUU 12337 cuAAcAccAcuGGAAGcuudTsdT sense 2510-2529
10338 AAGCUUCCAGUGGUGUUAG 12338 AAGCUUCcAGUGGUGUuAGdTsdT antis
2512-2531 10339 AACACCACUGGAAGCUUGU 12339 AAcAccAcuGGAAGcuuGudTsdT
sense 2512-2531 10340 ACAAGCUUCCAGUGGUGUU 12340
AcAAGCUUCcAGUGGUGUUdTsdT antis 2513-2532 10341 ACACCACUGGAAGCUUGUG
12341 AcAccAcuGGAAGcuuGuGdTsdT sense 2513-2532 10342
CACAAGCUUCCAGUGGUGU 12342 cAcAAGCUUCcAGUGGUGUdTsdT antis 2514-2533
10343 CACCACUGGAAGCUUGUGC 12343 cAccAcuGGAAGcuuGuGcdTsdT sense
2514-2533 10344 GCACAAGCUUCCAGUGGUG 12344 GcAcAAGCUUCcAGUGGUGdTsdT
antis 2515-2534 10345 ACCACUGGAAGCUUGUGCA 12345
AccAcuGGAAGcuuGuGcAdTsdT sense 2515-2534 10346 UGCACAAGCUUCCAGUGGU
12346 UGcAcAAGCUUCcAGUGGUdTsdT antis 2517-2536 10347
CACUGGAAGCUUGUGCACA 12347 cAcuGGAAGcuuGuGcAcAdTsdT sense 2517-2536
10348 UGUGCACAAGCUUCCAGUG 12348 UGUGcAcAAGCUUCcAGUGdTsdT antis
2519-2538 10349 CUGGAAGCUUGUGCACAUU 12349 cuGGAAGcuuGuGcAcAuudTsdT
sense 2519-2538 10350 AAUGUGCACAAGCUUCCAG 12350
AAUGUGcAcAAGCUUCcAGdTsdT antis 2520-2539 10351 UGGAAGCUUGUGCACAUUC
12351 uGGAAGcuuGuGcAcAuucdTsdT sense 2520-2539 10352
GAAUGUGCACAAGCUUCCA 12352 GAAUGUGcAcAAGCUUCcAdTsdT antis 2521-2540
10353 GGAAGCUUGUGCACAUUCA 12353 GGAAGcuuGuGcAcAuucAdTsdT sense
2521-2540 10354 UGAAUGUGCACAAGCUUCC 12354 UGAAUGUGcAcAAGCUUCCdTsdT
antis 2522-2541 10355 GAAGCUUGUGCACAUUCAU 12355
GAAGcuuGuGcAcAuucAudTsdT sense 2522-2541 10356 AUGAAUGUGCACAAGCUUC
12356 AUGAAUGUGcAcAAGCUUCdTsdT antis 2524-2543 10357
AGCUUGUGCACAUUCAUUU 12357 AGcuuGuGcAcAuucAuuudTsdT sense 2524-2543
10358 AAAUGAAUGUGCACAAGCU 12358 AAAUGAAUGUGcAcAAGCUdTsdT antis
1560-1579 10359 AGAGCUGCAAGCCAGUGCA 12359 AGAGcuGcAAGccAGuGcAdTsdT
sense
1560-1579 10360 UGCACUGGCUUGCAGCUCU 12360 UGcACUGGCUUGcAGCUCUdTsdT
antis 1561-1580 10361 GAGCUGCAAGCCAGUGCAG 12361
GAGcuGcAAGccAGuGcAGdTsdT sense 1561-1580 10362 CUGCACUGGCUUGCAGCUC
12362 CUGcACUGGCUUGcAGCUCdTsdT antis 1575-1594 10363
UGCAGCAGCCUUCAGCUUU 12363 uGcAGcAGccuucAGcuuudTsdT sense 1575-1594
10364 AAAGCUGAAGGCUGCUGCA 12364 AAAGCUGAAGGCUGCUGcAdTsdT antis
1611-1630 10365 GCAGAGAUAAAGAUGGCAG 12365 GcAGAGAuAAAGAuGGcAGdTsdT
sense 1611-1630 10366 CUGCCAUCUUUAUCUCUGC 12366
CUGCcAUCUUuAUCUCUGCdTsdT antis 1661-1680 10367 CAGGGUCCUGACAGGCCAC
12367 cAGGGuccuGAcAGGccAcdTsdT sense 1661-1680 10368
GUGGCCUGUCAGGACCCUG 12368 GUGGCCUGUcAGGACCCUGdTsdT antis 1779-1798
10369 AGAAAGUUCUACAGGACAA 12369 AGAAAGuucuAcAGGAcAAdTsdT sense
1779-1798 10370 UUGUCCUGUAGAACUUUCU 12370 UUGUCCUGuAGAACUUUCUdTsdT
antis 1917-1936 10371 UGCUGGACUAUGUUCCGGA 12371
uGcuGGAcuAuGuuccGGAdTsdT sense 1917-1936 10372 UCCGGAACAUAGUCCAGCA
12372 UCCGGAAcAuAGUCcAGcAdTsdT antis 2012-2031 10373
UAUCAGCUGUUCAGAAGUC 12373 uAucAGcuGuucAGAAGucdTsdT sense 2012-2031
10374 GACUUCUGAACAGCUGAUA 12374 GACUUCUGAAcAGCUGAuAdTsdT antis
2042-2061 10375 CAUUCCUUUGGAAUCUGCC 12375 cAuuccuuuGGAAucuGccdTsdT
sense 2042-2061 10376 GGCAGAUUCCAAAGGAAUG 12376
GGcAGAUUCcAAAGGAAUGdTsdT antis 2053-2072 10377 AAUCUGCCAUCGAGACAUU
12377 AAucuGccAucGAGAcAuudTsdT sense 2053-2072 10378
AAUGUCUCGAUGGCAGAUU 12378 AAUGUCUCGAUGGcAGAUUdTsdT antis 2066-2085
10379 GACAUUAAACCACAGAACC 12379 GAcAuuAAAccAcAGAAccdTsdT sense
2066-2085 10380 GGUUCUGUGGUUUAAUGUC 12380 GGUUCUGUGGUUuAAUGUCdTsdT
antis 2149-2168 10381 CCGAGGAGAGCCCAAUGUU 12381
ccGAGGAGAGcccAAuGuudTsdT sense 2149-2168 10382 AACAUUGGGCUCUCCUCGG
12382 AAcAUUGGGCUCUCCUCGGdTsdT antis 2248-2267 10383
GUCUGCAGGCUGUGUGUUG 12383 GucuGcAGGcuGuGuGuuGdTsdT sense 2248-2267
10384 CAACACACAGCCUGCAGAC 12384 cAAcAcAcAGCCUGcAGACdTsdT antis
2302-2321 10385 GGACAGUGGUGUGGAUCAG 12385 GGAcAGuGGuGuGGAucAGdTsdT
sense 2302-2321 10386 CUGAUCCACACCACUGUCC 12386
CUGAUCcAcACcACUGUCCdTsdT antis 2330-2349 10387 AUAAUAAAGGUCCUAGGAA
12387 AuAAuAAAGGuccuAGGAAdTsdT sense 2330-2349 10388
UUCCUAGGACCUUUAUUAU 12388 UUCCuAGGACCUUuAUuAUdTsdT antis 2362-2381
10389 GCAAAUUAGAGAAAUGAAC 12389 GcAAAuuAGAGAAAuGAAcdTsdT sense
2362-2381 10390 GUUCAUUUCUCUAAUUUGC 12390 GUUcAUUUCUCuAAUUUGCdTsdT
antis 2366-2385 10391 AUUAGAGAAAUGAACCCAA 12391
AuuAGAGAAAuGAAcccAAdTsdT sense 2366-2385 10392 UUGGGUUCAUUUCUCUAAU
12392 UUGGGUUcAUUUCUCuAAUdTsdT antis 2378-2397 10393
AACCCAAAUUAUACAGAAU 12393 AAcccAAAuuAuAcAGAAudTsdT sense 2378-2397
10394 AUUCUGUAUAAUUUGGGUU 12394 AUUCUGuAuAAUUUGGGUUdTsdT antis
2432-2451 10395 AAGGUCUUCCGGCCCCGAA 12395 AAGGucuuccGGccccGAAdTsdT
sense 2432-2451 10396 UUCGGGGCCGGAAGACCUU 12396
UUCGGGGCCGGAAGACCUUdTsdT antis 2441-2460 10397 CGGCCCCGAACUCCACCAG
12397 cGGccccGAAcuccAccAGdTsdT sense 2441-2460 10398
CUGGUGGAGUUCGGGGCCG 12398 CUGGUGGAGUUCGGGGCCGdTsdT antis 2456-2475
10399 CCAGAGGCAAUUGCACUGU 12399 ccAGAGGcAAuuGcAcuGudTsdT sense
2456-2475 10400 ACAGUGCAAUUGCCUCUGG 12400 AcAGUGcAAUUGCCUCUGGdTsdT
antis 2472-2491 10401 UGUGCAGCCGUCUGCUGGA 12401
uGuGcAGccGucuGcuGGAdTsdT sense 2472-2491 10402 UCCAGCAGACGGCUGCACA
12402 UCcAGcAGACGGCUGcAcAdTsdT antis 1538-1557 10403
CCGAGAACCACCUCCUUUG 12403 ccGAGAAccAccuccuuuGdTsdT sense 1538-1557
10404 CAAAGGAGGUGGUUCUCGG 12404 cAAAGGAGGUGGUUCUCGGdTsdT antis
1539-1558 10405 CGAGAACCACCUCCUUUGC 12405 cGAGAAccAccuccuuuGcdTsdT
sense 1539-1558 10406 GCAAAGGAGGUGGUUCUCG 12406
GcAAAGGAGGUGGUUCUCGdTsdT antis 1547-1566 10407 ACCUCCUUUGCGGAGAGCU
12407 AccuccuuuGcGGAGAGcudTsdT sense 1547-1566 10408
AGCUCUCCGCAAAGGAGGU 12408 AGCUCUCCGcAAAGGAGGUdTsdT antis 1551-1570
10409 CCUUUGCGGAGAGCUGCAA 12409 ccuuuGcGGAGAGcuGcAAdTsdT sense
1551-1570 10410 UUGCAGCUCUCCGCAAAGG 12410 UUGcAGCUCUCCGcAAAGGdTsdT
antis 1558-1577 10411 GGAGAGCUGCAAGCCAGUG 12411
GGAGAGcuGcAAGccAGuGdTsdT sense 1558-1577 10412 CACUGGCUUGCAGCUCUCC
12412 cACUGGCUUGcAGCUCUCCdTsdT antis 1573-1592 10413
AGUGCAGCAGCCUUCAGCU 12413 AGuGcAGcAGccuucAGcudTsdT sense 1573-1592
10414 AGCUGAAGGCUGCUGCACU 12414 AGCUGAAGGCUGCUGcACUdTsdT antis
1574-1593 10415 GUGCAGCAGCCUUCAGCUU 12415 GuGcAGcAGccuucAGcuudTsdT
sense 1574-1593 10416 AAGCUGAAGGCUGCUGCAC 12416
AAGCUGAAGGCUGCUGcACdTsdT antis 1584-1603 10417 CUUCAGCUUUUGGUAGCAU
12417 cuucAGcuuuuGGuAGcAudTsdT sense 1584-1603 10418
AUGCUACCAAAAGCUGAAG 12418 AUGCuACcAAAAGCUGAAGdTsdT antis 1594-1613
10419 UGGUAGCAUGAAAGUUAGC 12419 uGGuAGcAuGAAAGuuAGcdTsdT sense
1594-1613 10420 GCUAACUUUCAUGCUACCA 12420 GCuAACUUUcAUGCuACcAdTsdT
antis 1599-1618 10421 GCAUGAAAGUUAGCAGAGA 12421
GcAuGAAAGuuAGcAGAGAdTsdT sense 1599-1618 10422 UCUCUGCUAACUUUCAUGC
12422 UCUCUGCuAACUUUcAUGCdTsdT antis 1600-1619 10423
CAUGAAAGUUAGCAGAGAU 12423 cAuGAAAGuuAGcAGAGAudTsdT sense 1600-1619
10424 AUCUCUGCUAACUUUCAUG 12424 AUCUCUGCuAACUUUcAUGdTsdT antis
1613-1632 10425 AGAGAUAAAGAUGGCAGCA 12425 AGAGAuAAAGAuGGcAGcAdTsdT
sense 1613-1632 10426 UGCUGCCAUCUUUAUCUCU 12426
UGCUGCcAUCUUuAUCUCUdTsdT antis 1614-1633 10427 GAGAUAAAGAUGGCAGCAA
12427 GAGAuAAAGAuGGcAGcAAdTsdT sense 1614-1633 10428
UUGCUGCCAUCUUUAUCUC 12428 UUGCUGCcAUCUUuAUCUCdTsdT antis 1630-1649
10429 CAAGGUAACCACAGUAGUG 12429 cAAGGuAAccAcAGuAGuGdTsdT sense
1630-1649 10430 CACUACUGUGGUUACCUUG 12430 cACuACUGUGGUuACCUUGdTsdT
antis 1650-1669 10431 CAACUCCUGGCCAGGGUCC 12431
cAAcuccuGGccAGGGuccdTsdT sense 1650-1669 10432 GGACCCUGGCCAGGAGUUG
12432 GGACCCUGGCcAGGAGUUGdTsdT antis 1652-1671 10433
ACUCCUGGCCAGGGUCCUG 12433 AcuccuGGccAGGGuccuGdTsdT sense 1652-1671
10434 CAGGACCCUGGCCAGGAGU 12434 cAGGACCCUGGCcAGGAGUdTsdT antis
1653-1672 10435 CUCCUGGCCAGGGUCCUGA 12435 cuccuGGccAGGGuccuGAdTsdT
sense 1653-1672 10436 UCAGGACCCUGGCCAGGAG 12436
UcAGGACCCUGGCcAGGAGdTsdT antis 1654-1673 10437 UCCUGGCCAGGGUCCUGAC
12437 uccuGGccAGGGuccuGAcdTsdT sense 1654-1673 10438
GUCAGGACCCUGGCCAGGA 12438 GUcAGGACCCUGGCcAGGAdTsdT antis 1665-1684
10439 GUCCUGACAGGCCACAGGA 12439 GuccuGAcAGGccAcAGGAdTsdT sense
1665-1684 10440 UCCUGUGGCCUGUCAGGAC 12440 UCCUGUGGCCUGUcAGGACdTsdT
antis 1673-1692 10441 AGGCCACAGGAAGUCAGUU 12441
AGGccAcAGGAAGucAGuudTsdT sense 1673-1692 10442 AACUGACUUCCUGUGGCCU
12442 AACUGACUUCCUGUGGCCUdTsdT antis 1688-1707 10443
AGUUAUACAGACACGAAAG 12443 AGuuAuAcAGAcAcGAAAGdTsdT sense 1688-1707
10444 CUUUCGUGUCUGUAUAACU 12444 CUUUCGUGUCUGuAuAACUdTsdT antis
1743-1762 10445 CCAAACUUUGUGAUUCUGG 12445 ccAAAcuuuGuGAuucuGGdTsdT
sense 1743-1762 10446 CCAGAAUCACAAAGUUUGG 12446
CcAGAAUcAcAAAGUUUGGdTsdT antis 1744-1763 10447 CAAACUUUGUGAUUCUGGA
12447 cAAAcuuuGuGAuucuGGAdTsdT sense 1744-1763 10448
UCCAGAAUCACAAAGUUUG 12448 UCcAGAAUcAcAAAGUUUGdTsdT antis 1745-1764
10449 AAACUUUGUGAUUCUGGAG 12449 AAAcuuuGuGAuucuGGAGdTsdT sense
1745-1764 10450 CUCCAGAAUCACAAAGUUU 12450 CUCcAGAAUcAcAAAGUUUdTsdT
antis 1746-1765 10451 AACUUUGUGAUUCUGGAGA 12451
AAcuuuGuGAuucuGGAGAdTsdT sense 1746-1765 10452 UCUCCAGAAUCACAAAGUU
12452 UCUCcAGAAUcAcAAAGUUdTsdT antis 1780-1799 10453
GAAAGUUCUACAGGACAAG 12453 GAAAGuucuAcAGGAcAAGdTsdT sense 1780-1799
10454 CUUGUCCUGUAGAACUUUC 12454 CUUGUCCUGuAGAACUUUCdTsdT antis
1781-1800 10455 AAAGUUCUACAGGACAAGC 12455 AAAGuucuAcAGGAcAAGcdTsdT
sense 1781-1800 10456 GCUUGUCCUGUAGAACUUU 12456
GCUUGUCCUGuAGAACUUUdTsdT antis 1782-1801 10457 AAGUUCUACAGGACAAGCG
12457 AAGuucuAcAGGAcAAGcGdTsdT sense 1782-1801 10458
CGCUUGUCCUGUAGAACUU 12458 CGCUUGUCCUGuAGAACUUdTsdT antis 1809-1828
10459 ACCGAGAGCUCCAGAUCAU 12459 AccGAGAGcuccAGAucAudTsdT sense
1809-1828 10460 AUGAUCUGGAGCUCUCGGU 12460 AUGAUCUGGAGCUCUCGGUdTsdT
antis 1880-1899 10461 AGUGGUGAGAAGAAAGAUG 12461
AGuGGuGAGAAGAAAGAuGdTsdT sense 1880-1899 10462 CAUCUUUCUUCUCACCACU
12462 cAUCUUUCUUCUcACcACUdTsdT antis 1885-1904 10463
UGAGAAGAAAGAUGAGGUC 12463 uGAGAAGAAAGAuGAGGucdTsdT sense 1885-1904
10464 GACCUCAUCUUUCUUCUCA 12464 GACCUcAUCUUUCUUCUcAdTsdT antis
1889-1908 10465 AAGAAAGAUGAGGUCUACC 12465 AAGAAAGAuGAGGucuAccdTsdT
sense 1889-1908 10466 GGUAGACCUCAUCUUUCUU 12466
GGuAGACCUcAUCUUUCUUdTsdT antis 2043-2062 10467 AUUCCUUUGGAAUCUGCCA
12467 AuuccuuuGGAAucuGccAdTsdT sense 2043-2062 10468
UGGCAGAUUCCAAAGGAAU 12468 UGGcAGAUUCcAAAGGAAUdTsdT antis 2050-2069
10469 UGGAAUCUGCCAUCGAGAC 12469 uGGAAucuGccAucGAGAcdTsdT sense
2050-2069 10470 GUCUCGAUGGCAGAUUCCA 12470 GUCUCGAUGGcAGAUUCcAdTsdT
antis 2092-2111 10471 GGAUCCUGAUACAGCUGUA 12471
GGAuccuGAuAcAGcuGuAdTsdT sense 2092-2111 10472 UACAGCUGUAUCAGGAUCC
12472 uAcAGCUGuAUcAGGAUCCdTsdT antis 2116-2135 10473
ACUCUGUGACUUUGGAAGU 12473 AcucuGuGAcuuuGGAAGudTsdT sense 2116-2135
10474 ACUUCCAAAGUCACAGAGU 12474 ACUUCcAAAGUcAcAGAGUdTsdT antis
2143-2162 10475 GCUGGUCCGAGGAGAGCCC 12475 GcuGGuccGAGGAGAGcccdTsdT
sense 2143-2162 10476 GGGCUCUCCUCGGACCAGC 12476
GGGCUCUCCUCGGACcAGCdTsdT antis 2159-2178 10477 CCCAAUGUUUCAUAUAUCU
12477 cccAAuGuuucAuAuAucudTsdT sense 2159-2178 10478
AGAUAUAUGAAACAUUGGG 12478 AGAuAuAUGAAAcAUUGGGdTsdT antis 2163-2182
10479 AUGUUUCAUAUAUCUGUUC 12479 AuGuuucAuAuAucuGuucdTsdT sense
2163-2182 10480 GAACAGAUAUAUGAAACAU 12480 GAAcAGAuAuAUGAAAcAUdTsdT
antis 2207-2226 10481 AUCUUUGGAGCCACUGAUU 12481
AucuuuGGAGccAcuGAuudTsdT sense 2207-2226 10482 AAUCAGUGGCUCCAAAGAU
12482 AAUcAGUGGCUCcAAAGAUdTsdT antis 2247-2266 10483
GGUCUGCAGGCUGUGUGUU 12483 GGucuGcAGGcuGuGuGuudTsdT sense 2247-2266
10484 AACACACAGCCUGCAGACC 12484 AAcAcAcAGCCUGcAGACCdTsdT antis
2251-2270 10485 UGCAGGCUGUGUGUUGGCU 12485 uGcAGGcuGuGuGuuGGcudTsdT
sense 2251-2270 10486 AGCCAACACACAGCCUGCA 12486
AGCcAAcAcAcAGCCUGcAdTsdT antis 2261-2280 10487 GUGUUGGCUGAAUUGUUGC
12487 GuGuuGGcuGAAuuGuuGcdTsdT sense 2261-2280 10488
GCAACAAUUCAGCCAACAC 12488 GcAAcAAUUcAGCcAAcACdTsdT antis 2298-2317
10489 CUGGGGACAGUGGUGUGGA 12489 cuGGGGAcAGuGGuGuGGAdTsdT sense
2298-2317 10490 UCCACACCACUGUCCCCAG 12490 UCcAcACcACUGUCCCcAGdTsdT
antis 2300-2319 10491 GGGGACAGUGGUGUGGAUC 12491
GGGGAcAGuGGuGuGGAucdTsdT sense 2300-2319 10492 GAUCCACACCACUGUCCCC
12492 GAUCcAcACcACUGUCCCCdTsdT antis 2301-2320 10493
GGGACAGUGGUGUGGAUCA 12493 GGGAcAGuGGuGuGGAucAdTsdT sense 2301-2320
10494 UGAUCCACACCACUGUCCC 12494 UGAUCcAcACcACUGUCCCdTsdT antis
2319-2338 10495 AGUUGGUGGAAAUAAUAAA 12495 AGuuGGuGGAAAuAAuAAAdTsdT
sense 2319-2338 10496 UUUAUUAUUUCCACCAACU 12496
UUuAUuAUUUCcACcAACUdTsdT antis 2323-2342 10497 GGUGGAAAUAAUAAAGGUC
12497 GGuGGAAAuAAuAAAGGucdTsdT sense 2323-2342 10498
GACCUUUAUUAUUUCCACC 12498 GACCUUuAUuAUUUCcACCdTsdT antis 2325-2344
10499 UGGAAAUAAUAAAGGUCCU 12499 uGGAAAuAAuAAAGGuccudTsdT sense
2325-2344 10500 AGGACCUUUAUUAUUUCCA 12500 AGGACCUUuAUuAUUUCcAdTsdT
antis 2363-2382 10501 CAAAUUAGAGAAAUGAACC 12501
cAAAuuAGAGAAAuGAAccdTsdT sense 2363-2382 10502 GGUUCAUUUCUCUAAUUUG
12502 GGUUcAUUUCUCuAAUUUGdTsdT antis 2376-2395 10503
UGAACCCAAAUUAUACAGA 12503 uGAAcccAAAuuAuAcAGAdTsdT sense 2376-2395
10504 UCUGUAUAAUUUGGGUUCA 12504 UCUGuAuAAUUUGGGUUcAdTsdT antis
2377-2396 10505 GAACCCAAAUUAUACAGAA 12505 GAAcccAAAuuAuAcAGAAdTsdT
sense 2377-2396 10506 UUCUGUAUAAUUUGGGUUC 12506
UUCUGuAuAAUUUGGGUUCdTsdT antis 2383-2402 10507 AAAUUAUACAGAAUUCAAA
12507 AAAuuAuAcAGAAuucAAAdTsdT sense 2383-2402 10508
UUUGAAUUCUGUAUAAUUU 12508 UUUGAAUUCUGuAuAAUUUdTsdT antis 2391-2410
10509 CAGAAUUCAAAUUCCCUCA 12509 cAGAAuucAAAuucccucAdTsdT sense
2391-2410 10510 UGAGGGAAUUUGAAUUCUG 12510 UGAGGGAAUUUGAAUUCUGdTsdT
antis 2394-2413 10511 AAUUCAAAUUCCCUCAAAU 12511
AAuucAAAuucccucAAAudTsdT sense 2394-2413 10512 AUUUGAGGGAAUUUGAAUU
12512 AUUUGAGGGAAUUUGAAUUdTsdT antis 2436-2455 10513
UCUUCCGGCCCCGAACUCC 12513 ucuuccGGccccGAAcuccdTsdT sense 2436-2455
10514 GGAGUUCGGGGCCGGAAGA 12514 GGAGUUCGGGGCCGGAAGAdTsdT antis
2442-2461 10515 GGCCCCGAACUCCACCAGA 12515 GGccccGAAcuccAccAGAdTsdT
sense 2442-2461 10516 UCUGGUGGAGUUCGGGGCC 12516
UCUGGUGGAGUUCGGGGCCdTsdT antis 2449-2468 10517 AACUCCACCAGAGGCAAUU
12517 AAcuccAccAGAGGcAAuudTsdT sense 2449-2468 10518
AAUUGCCUCUGGUGGAGUU 12518 AAUUGCCUCUGGUGGAGUUdTsdT antis 2450-2469
10519 ACUCCACCAGAGGCAAUUG 12519 AcuccAccAGAGGcAAuuGdTsdT sense
2450-2469 10520 CAAUUGCCUCUGGUGGAGU 12520 cAAUUGCCUCUGGUGGAGUdTsdT
antis 2457-2476 10521 CAGAGGCAAUUGCACUGUG 12521
cAGAGGcAAuuGcAcuGuGdTsdT sense 2457-2476 10522 CACAGUGCAAUUGCCUCUG
12522 cAcAGUGcAAUUGCCUCUGdTsdT antis 2470-2489 10523
ACUGUGCAGCCGUCUGCUG 12523 AcuGuGcAGccGucuGcuGdTsdT sense 2470-2489
10524 CAGCAGACGGCUGCACAGU 12524 cAGcAGACGGCUGcAcAGUdTsdT antis
2473-2492 10525 GUGCAGCCGUCUGCUGGAG 12525 GuGcAGccGucuGcuGGAGdTsdT
sense 2473-2492 10526 CUCCAGCAGACGGCUGCAC 12526
CUCcAGcAGACGGCUGcACdTsdT antis 2475-2494 10527 GCAGCCGUCUGCUGGAGUA
12527 GcAGccGucuGcuGGAGuAdTsdT sense 2475-2494 10528
UACUCCAGCAGACGGCUGC 12528 uACUCcAGcAGACGGCUGCdTsdT antis 1612-1631
10529 CAGAGAUAAAGAUGGCAGC 12529 cAGAGAuAAAGAuGGcAGcdTsdT sense
1612-1631 10530 GCUGCCAUCUUUAUCUCUG 12530 GCUGCcAUCUUuAUCUCUGdTsdT
antis 1804-1823 10531 UAAGAACCGAGAGCUCCAG 12531
uAAGAAccGAGAGcuccAGdTsdT sense 1804-1823 10532 CUGGAGCUCUCGGUUCUUA
12532 CUGGAGCUCUCGGUUCUuAdTsdT antis 1805-1824 10533
AAGAACCGAGAGCUCCAGA 12533 AAGAAccGAGAGcuccAGAdTsdT sense 1805-1824
10534 UCUGGAGCUCUCGGUUCUU 12534 UCUGGAGCUCUCGGUUCUUdTsdT antis
1888-1907 10535 GAAGAAAGAUGAGGUCUAC 12535 GAAGAAAGAuGAGGucuAcdTsdT
sense 1888-1907 10536 GUAGACCUCAUCUUUCUUC 12536
GuAGACCUcAUCUUUCUUCdTsdT antis 2165-2184 10537 GUUUCAUAUAUCUGUUCUC
12537 GuuucAuAuAucuGuucucdTsdT sense 2165-2184 10538
GAGAACAGAUAUAUGAAAC 12538 GAGAAcAGAuAuAUGAAACdTsdT antis 2332-2351
10539 AAUAAAGGUCCUAGGAACA 12539 AAuAAAGGuccuAGGAAcAdTsdT sense
2332-2351 10540 UGUUCCUAGGACCUUUAUU 12540 UGUUCCuAGGACCUUuAUUdTsdT
antis 2518-2537 10541 ACUGGAAGCUUGUGCACAU 12541
AcuGGAAGcuuGuGcAcAudTsdT sense 2518-2537 10542 AUGUGCACAAGCUUCCAGU
12542 AUGUGcAcAAGCUUCcAGUdTsdT antis 1565-1584 10543
UGCAAGCCAGUGCAGCAGC 12543 uGcAAGccAGuGcAGcAGcdTsdT sense 1565-1584
10544 GCUGCUGCACUGGCUUGCA 12544 GCUGCUGcACUGGCUUGcAdTsdT antis
1569-1588 10545 AGCCAGUGCAGCAGCCUUC 12545 AGccAGuGcAGcAGccuucdTsdT
sense 1569-1588 10546 GAAGGCUGCUGCACUGGCU 12546
GAAGGCUGCUGcACUGGCUdTsdT antis 1631-1650 10547 AAGGUAACCACAGUAGUGG
12547 AAGGuAAccAcAGuAGuGGdTsdT sense 1631-1650 10548
CCACUACUGUGGUUACCUU 12548 CcACuACUGUGGUuACCUUdTsdT antis 1659-1678
10549 GCCAGGGUCCUGACAGGCC 12549 GccAGGGuccuGAcAGGccdTsdT sense
1659-1678 10550 GGCCUGUCAGGACCCUGGC 12550 GGCCUGUcAGGACCCUGGCdTsdT
antis 1711-1730 10551 UGGAAAUGGAUCAUUUGGU 12551
uGGAAAuGGAucAuuuGGudTsdT sense 1711-1730 10552 ACCAAAUGAUCCAUUUCCA
12552 ACcAAAUGAUCcAUUUCcAdTsdT antis 1756-1775 10553
UUCUGGAGAACUGGUUGCC 12553 uucuGGAGAAcuGGuuGccdTsdT sense 1756-1775
10554 GGCAACCAGUUCUCCAGAA 12554 GGcAACcAGUUCUCcAGAAdTsdT antis
1761-1780 10555 GAGAACUGGUUGCCAUCAA 12555 GAGAAcuGGuuGccAucAAdTsdT
sense 1761-1780 10556 UUGAUGGCAACCAGUUCUC 12556
UUGAUGGcAACcAGUUCUCdTsdT antis 1762-1781 10557 AGAACUGGUUGCCAUCAAG
12557 AGAAcuGGuuGccAucAAGdTsdT sense 1762-1781 10558
CUUGAUGGCAACCAGUUCU 12558 CUUGAUGGcAACcAGUUCUdTsdT antis 1997-2016
10559 GUCAAGUUGUAUAUGUAUC 12559 GucAAGuuGuAuAuGuAucdTsdT sense
1997-2016 10560 GAUACAUAUACAACUUGAC 12560 GAuAcAuAuAcAACUUGACdTsdT
antis 2040-2059 10561 UCCAUUCCUUUGGAAUCUG 12561
uccAuuccuuuGGAAucuGdTsdT sense 2040-2059 10562 CAGAUUCCAAAGGAAUGGA
12562 cAGAUUCcAAAGGAAUGGAdTsdT antis 2133-2152 10563
GUGCAAAGCAGCUGGUCCG 12563 GuGcAAAGcAGcuGGuccGdTsdT sense 2133-2152
10564 CGGACCAGCUGCUUUGCAC 12564 CGGACcAGCUGCUUUGcACdTsdT antis
2186-2205 10565 UACUACAGGGCACCAGAGU 12565 uAcuAcAGGGcAccAGAGudTsdT
sense 2186-2205 10566 ACUCUGGUGCCCUGUAGUA 12566
ACUCUGGUGCCCUGuAGuAdTsdT antis 2250-2269 10567 CUGCAGGCUGUGUGUUGGC
12567 cuGcAGGcuGuGuGuuGGcdTsdT sense 2250-2269 10568
GCCAACACACAGCCUGCAG 12568 GCcAAcAcAcAGCCUGcAGdTsdT antis 2466-2485
10569 UUGCACUGUGCAGCCGUCU 12569 uuGcAcuGuGcAGccGucudTsdT sense
2466-2485 10570 AGACGGCUGCACAGUGCAA 12570 AGACGGCUGcAcAGUGcAAdTsdT
antis 2523-2542 10571 AAGCUUGUGCACAUUCAUU 12571
AAGcuuGuGcAcAuucAuudTsdT sense 2523-2542 10572 AAUGAAUGUGCACAAGCUU
12572 AAUGAAUGUGcAcAAGCUUdTsdT antis 1548-1567 10573
CCUCCUUUGCGGAGAGCUG 12573 ccuccuuuGcGGAGAGcuGdTsdT sense 1548-1567
10574 CAGCUCUCCGCAAAGGAGG 12574 cAGCUCUCCGcAAAGGAGGdTsdT antis
1566-1585 10575 GCAAGCCAGUGCAGCAGCC 12575 GcAAGccAGuGcAGcAGccdTsdT
sense 1566-1585 10576 GGCUGCUGCACUGGCUUGC 12576
GGCUGCUGcACUGGCUUGCdTsdT antis 1656-1675 10577 CUGGCCAGGGUCCUGACAG
12577 cuGGccAGGGuccuGAcAGdTsdT sense 1656-1675 10578
CUGUCAGGACCCUGGCCAG 12578 CUGUcAGGACCCUGGCcAGdTsdT antis 1763-1782
10579 GAACUGGUUGCCAUCAAGA 12579 GAAcuGGuuGccAucAAGAdTsdT sense
1763-1782 10580 UCUUGAUGGCAACCAGUUC 12580 UCUUGAUGGcAACcAGUUCdTsdT
antis 2185-2204 10581 GUACUACAGGGCACCAGAG 12581
GuAcuAcAGGGcAccAGAGdTsdT sense 2185-2204 10582 CUCUGGUGCCCUGUAGUAC
12582 CUCUGGUGCCCUGuAGuACdTsdT antis 2212-2231 10583
UGGAGCCACUGAUUACACG 12583 uGGAGccAcuGAuuAcAcGdTsdT sense 2212-2231
10584 CGUGUAAUCAGUGGCUCCA 12584 CGUGuAAUcAGUGGCUCcAdTsdT antis
2265-2284 10585 UGGCUGAAUUGUUGCUAGG 12585 uGGcuGAAuuGuuGcuAGGdTsdT
sense 2265-2284 10586 CCUAGCAACAAUUCAGCCA 12586
CCuAGcAAcAAUUcAGCcAdTsdT antis 2326-2345 10587 GGAAAUAAUAAAGGUCCUA
12587 GGAAAuAAuAAAGGuccuAdTsdT sense 2326-2345 10588
UAGGACCUUUAUUAUUUCC 12588 uAGGACCUUuAUuAUUUCCdTsdT antis 2425-2444
10589 UUGGACAAAGGUCUUCCGG 12589 uuGGAcAAAGGucuuccGGdTsdT sense
2425-2444 10590 CCGGAAGACCUUUGUCCAA 12590 CCGGAAGACCUUUGUCcAAdTsdT
antis 1962-1981 10591 AUAGUCGAGCCAAGCAGAC 12591
AuAGucGAGccAAGcAGAcdTsdT sense 1962-1981 10592 GUCUGCUUGGCUCGACUAU
12592 GUCUGCUUGGCUCGACuAUdTsdT antis 1803-1822 10593
UUAAGAACCGAGAGCUCCA 12593 uuAAGAAccGAGAGcuccAdTsdT sense 1803-1822
10594 UGGAGCUCUCGGUUCUUAA 12594 UGGAGCUCUCGGUUCUuAAdTsdT antis
1808-1827 10595 AACCGAGAGCUCCAGAUCA 12595 AAccGAGAGcuccAGAucAdTsdT
sense 1808-1827 10596 UGAUCUGGAGCUCUCGGUU 12596
UGAUCUGGAGCUCUCGGUUdTsdT antis 1603-1622 10597 GAAAGUUAGCAGAGAUAAA
12597 GAAAGuuAGcAGAGAuAAAdTsdT sense 1603-1622 10598
UUUAUCUCUGCUAACUUUC 12598 UUuAUCUCUGCuAACUUUCdTsdT antis 1640-1659
10599 ACAGUAGUGGCAACUCCUG 12599 AcAGuAGuGGcAAcuccuGdTsdT sense
1640-1659 10600 CAGGAGUUGCCACUACUGU 12600 cAGGAGUUGCcACuACUGUdTsdT
antis 1718-1737 10601 GGAUCAUUUGGUGUGGUAU 12601
GGAucAuuuGGuGuGGuAudTsdT sense 1718-1737 10602 AUACCACACCAAAUGAUCC
12602 AuACcAcACcAAAUGAUCCdTsdT antis 1807-1826 10603
GAACCGAGAGCUCCAGAUC 12603 GAAccGAGAGcuccAGAucdTsdT sense 1807-1826
10604 GAUCUGGAGCUCUCGGUUC 12604 GAUCUGGAGCUCUCGGUUCdTsdT antis
1904-1923 10605 UACCUUAACCUGGUGCUGG 12605 uAccuuAAccuGGuGcuGGdTsdT
sense 1904-1923 10606 CCAGCACCAGGUUAAGGUA 12606
CcAGcACcAGGUuAAGGuAdTsdT antis 1905-1924 10607 ACCUUAACCUGGUGCUGGA
12607 AccuuAAccuGGuGcuGGAdTsdT sense 1905-1924 10608
UCCAGCACCAGGUUAAGGU 12608 UCcAGcACcAGGUuAAGGUdTsdT antis 1906-1925
10609 CCUUAACCUGGUGCUGGAC 12609 ccuuAAccuGGuGcuGGAcdTsdT sense
1906-1925 10610 GUCCAGCACCAGGUUAAGG 12610 GUCcAGcACcAGGUuAAGGdTsdT
antis
2015-2034 10611 CAGCUGUUCAGAAGUCUAG 12611 cAGcuGuucAGAAGucuAGdTsdT
sense 2015-2034 10612 CUAGACUUCUGAACAGCUG 12612
CuAGACUUCUGAAcAGCUGdTsdT antis 2057-2076 10613 UGCCAUCGAGACAUUAAAC
12613 uGccAucGAGAcAuuAAAcdTsdT sense 2057-2076 10614
GUUUAAUGUCUCGAUGGCA 12614 GUUuAAUGUCUCGAUGGcAdTsdT antis 2109-2128
10615 UAUUAAAACUCUGUGACUU 12615 uAuuAAAAcucuGuGAcuudTsdT sense
2109-2128 10616 AAGUCACAGAGUUUUAAUA 12616 AAGUcAcAGAGUUUuAAuAdTsdT
antis 2126-2145 10617 UUUGGAAGUGCAAAGCAGC 12617
uuuGGAAGuGcAAAGcAGcdTsdT sense 2126-2145 10618 GCUGCUUUGCACUUCCAAA
12618 GCUGCUUUGcACUUCcAAAdTsdT antis 2129-2148 10619
GGAAGUGCAAAGCAGCUGG 12619 GGAAGuGcAAAGcAGcuGGdTsdT sense 2129-2148
10620 CCAGCUGCUUUGCACUUCC 12620 CcAGCUGCUUUGcACUUCCdTsdT antis
2312-2331 10621 GUGGAUCAGUUGGUGGAAA 12621 GuGGAucAGuuGGuGGAAAdTsdT
sense 2312-2331 10622 UUUCCACCAACUGAUCCAC 12622
UUUCcACcAACUGAUCcACdTsdT antis 2313-2332 10623 UGGAUCAGUUGGUGGAAAU
12623 uGGAucAGuuGGuGGAAAudTsdT sense 2313-2332 10624
AUUUCCACCAACUGAUCCA 12624 AUUUCcACcAACUGAUCcAdTsdT antis 2347-2366
10625 AACACCAACAAGGGAGCAA 12625 AAcAccAAcAAGGGAGcAAdTsdT sense
2347-2366 10626 UUGCUCCCUUGUUGGUGUU 12626 UUGCUCCCUUGUUGGUGUUdTsdT
antis 2373-2392 10627 AAAUGAACCCAAAUUAUAC 12627
AAAuGAAcccAAAuuAuAcdTsdT sense 2373-2392 10628 GUAUAAUUUGGGUUCAUUU
12628 GuAuAAUUUGGGUUcAUUUdTsdT antis 2431-2450 10629
AAAGGUCUUCCGGCCCCGA 12629 AAAGGucuuccGGccccGAdTsdT sense 2431-2450
10630 UCGGGGCCGGAAGACCUUU 12630 UCGGGGCCGGAAGACCUUUdTsdT antis
1632-1651 10631 AGGUAACCACAGUAGUGGC 12631 AGGuAAccAcAGuAGuGGcdTsdT
sense 1632-1651 10632 GCCACUACUGUGGUUACCU 12632
GCcACuACUGUGGUuACCUdTsdT antis 2031-2050 10633 UAGCCUAUAUCCAUUCCUU
12633 uAGccuAuAuccAuuccuudTsdT sense 2031-2050 10634
AAGGAAUGGAUAUAGGCUA 12634 AAGGAAUGGAuAuAGGCuAdTsdT antis 1604-1623
10635 AAAGUUAGCAGAGAUAAAG 12635 AAAGuuAGcAGAGAuAAAGdTsdT sense
1604-1623 10636 CUUUAUCUCUGCUAACUUU 12636 CUUuAUCUCUGCuAACUUUdTsdT
antis 1605-1624 10637 AAGUUAGCAGAGAUAAAGA 12637
AAGuuAGcAGAGAuAAAGAdTsdT sense 1605-1624 10638 UCUUUAUCUCUGCUAACUU
12638 UCUUuAUCUCUGCuAACUUdTsdT antis 1634-1653 10639
GUAACCACAGUAGUGGCAA 12639 GuAAccAcAGuAGuGGcAAdTsdT sense 1634-1653
10640 UUGCCACUACUGUGGUUAC 12640 UUGCcACuACUGUGGUuACdTsdT antis
1662-1681 10641 AGGGUCCUGACAGGCCACA 12641 AGGGuccuGAcAGGccAcAdTsdT
sense 1662-1681 10642 UGUGGCCUGUCAGGACCCU 12642
UGUGGCCUGUcAGGACCCUdTsdT antis 1663-1682 10643 GGGUCCUGACAGGCCACAG
12643 GGGuccuGAcAGGccAcAGdTsdT sense 1663-1682 10644
CUGUGGCCUGUCAGGACCC 12644 CUGUGGCCUGUcAGGACCCdTsdT antis 1702-1721
10645 GAAAGUGAUUGGAAAUGGA 12645 GAAAGuGAuuGGAAAuGGAdTsdT sense
1702-1721 10646 UCCAUUUCCAAUCACUUUC 12646 UCcAUUUCcAAUcACUUUCdTsdT
antis 1772-1791 10647 GCCAUCAAGAAAGUUCUAC 12647
GccAucAAGAAAGuucuAcdTsdT sense 1772-1791 10648 GUAGAACUUUCUUGAUGGC
12648 GuAGAACUUUCUUGAUGGCdTsdT antis 1776-1795 10649
UCAAGAAAGUUCUACAGGA 12649 ucAAGAAAGuucuAcAGGAdTsdT sense 1776-1795
10650 UCCUGUAGAACUUUCUUGA 12650 UCCUGuAGAACUUUCUUGAdTsdT antis
1792-1811 10651 GGACAAGCGAUUUAAGAAC 12651 GGAcAAGcGAuuuAAGAAcdTsdT
sense 1792-1811 10652 GUUCUUAAAUCGCUUGUCC 12652
GUUCUuAAAUCGCUUGUCCdTsdT antis 1801-1820 10653 AUUUAAGAACCGAGAGCUC
12653 AuuuAAGAAccGAGAGcucdTsdT sense 1801-1820 10654
GAGCUCUCGGUUCUUAAAU 12654 GAGCUCUCGGUUCUuAAAUdTsdT antis 1813-1832
10655 AGAGCUCCAGAUCAUGAGA 12655 AGAGcuccAGAucAuGAGAdTsdT sense
1813-1832 10656 UCUCAUGAUCUGGAGCUCU 12656 UCUcAUGAUCUGGAGCUCUdTsdT
antis 1859-1878 10657 CUGCGGUAUUUCUUCUACU 12657
cuGcGGuAuuucuucuAcudTsdT sense 1859-1878 10658 AGUAGAAGAAAUACCGCAG
12658 AGuAGAAGAAAuACCGcAGdTsdT antis 1860-1879 10659
UGCGGUAUUUCUUCUACUC 12659 uGcGGuAuuucuucuAcucdTsdT sense 1860-1879
10660 GAGUAGAAGAAAUACCGCA 12660 GAGuAGAAGAAAuACCGcAdTsdT antis
1900-1919 10661 GGUCUACCUUAACCUGGUG 12661 GGucuAccuuAAccuGGuGdTsdT
sense 1900-1919 10662 CACCAGGUUAAGGUAGACC 12662
cACcAGGUuAAGGuAGACCdTsdT antis 1909-1928 10663 UAACCUGGUGCUGGACUAU
12663 uAAccuGGuGcuGGAcuAudTsdT sense 1909-1928 10664
AUAGUCCAGCACCAGGUUA 12664 AuAGUCcAGcACcAGGUuAdTsdT antis 1982-2001
10665 CUCCCUGUGAUCUAUGUCA 12665 cucccuGuGAucuAuGucAdTsdT sense
1982-2001 10666 UGACAUAGAUCACAGGGAG 12666 UGAcAuAGAUcAcAGGGAGdTsdT
antis 2125-2144 10667 CUUUGGAAGUGCAAAGCAG 12667
cuuuGGAAGuGcAAAGcAGdTsdT sense 2125-2144 10668 CUGCUUUGCACUUCCAAAG
12668 CUGCUUUGcACUUCcAAAGdTsdT antis 2137-2156 10669
AAAGCAGCUGGUCCGAGGA 12669 AAAGcAGcuGGuccGAGGAdTsdT sense 2137-2156
10670 UCCUCGGACCAGCUGCUUU 12670 UCCUCGGACcAGCUGCUUUdTsdT antis
2156-2175 10671 GAGCCCAAUGUUUCAUAUA 12671 GAGcccAAuGuuucAuAuAdTsdT
sense 2156-2175 10672 UAUAUGAAACAUUGGGCUC 12672
uAuAUGAAAcAUUGGGCUCdTsdT antis 2174-2193 10673 AUCUGUUCUCGGUACUACA
12673 AucuGuucucGGuAcuAcAdTsdT sense 2174-2193 10674
UGUAGUACCGAGAACAGAU 12674 UGuAGuACCGAGAAcAGAUdTsdT antis 2281-2300
10675 AGGACAACCAAUAUUUCCU 12675 AGGAcAAccAAuAuuuccudTsdT sense
2281-2300 10676 AGGAAAUAUUGGUUGUCCU 12676 AGGAAAuAUUGGUUGUCCUdTsdT
antis 2282-2301 10677 GGACAACCAAUAUUUCCUG 12677
GGAcAAccAAuAuuuccuGdTsdT sense 2282-2301 10678 CAGGAAAUAUUGGUUGUCC
12678 cAGGAAAuAUUGGUUGUCCdTsdT antis 2317-2336 10679
UCAGUUGGUGGAAAUAAUA 12679 ucAGuuGGuGGAAAuAAuAdTsdT sense 2317-2336
10680 UAUUAUUUCCACCAACUGA 12680 uAUuAUUUCcACcAACUGAdTsdT antis
2346-2365 10681 GAACACCAACAAGGGAGCA 12681 GAAcAccAAcAAGGGAGcAdTsdT
sense 2346-2365 10682 UGCUCCCUUGUUGGUGUUC 12682
UGCUCCCUUGUUGGUGUUCdTsdT antis 2401-2420 10683 AUUCCCUCAAAUCAAGGCA
12683 AuucccucAAAucAAGGcAdTsdT sense 2401-2420 10684
UGCCUUGAUUUGAGGGAAU 12684 UGCCUUGAUUUGAGGGAAUdTsdT antis 2402-2421
10685 UUCCCUCAAAUCAAGGCAC 12685 uucccucAAAucAAGGcAcdTsdT sense
2402-2421 10686 GUGCCUUGAUUUGAGGGAA 12686 GUGCCUUGAUUUGAGGGAAdTsdT
antis 2463-2482 10687 CAAUUGCACUGUGCAGCCG 12687
cAAuuGcAcuGuGcAGccGdTsdT sense 2463-2482 10688 CGGCUGCACAGUGCAAUUG
12688 CGGCUGcAcAGUGcAAUUGdTsdT antis 1537-1556 10689
ACCGAGAACCACCUCCUUU 12689 AccGAGAAccAccuccuuudTsdT sense 1537-1556
10690 AAAGGAGGUGGUUCUCGGU 12690 AAAGGAGGUGGUUCUCGGUdTsdT antis
1554-1573 10691 UUGCGGAGAGCUGCAAGCC 12691 uuGcGGAGAGcuGcAAGccdTsdT
sense 1554-1573 10692 GGCUUGCAGCUCUCCGCAA 12692
GGCUUGcAGCUCUCCGcAAdTsdT antis 1555-1574 10693 UGCGGAGAGCUGCAAGCCA
12693 uGcGGAGAGcuGcAAGccAdTsdT sense 1555-1574 10694
UGGCUUGCAGCUCUCCGCA 12694 UGGCUUGcAGCUCUCCGcAdTsdT antis 1562-1581
10695 AGCUGCAAGCCAGUGCAGC 12695 AGcuGcAAGccAGuGcAGcdTsdT sense
1562-1581 10696 GCUGCACUGGCUUGCAGCU 12696 GCUGcACUGGCUUGcAGCUdTsdT
antis 1563-1582 10697 GCUGCAAGCCAGUGCAGCA 12697
GcuGcAAGccAGuGcAGcAdTsdT sense 1563-1582 10698 UGCUGCACUGGCUUGCAGC
12698 UGCUGcACUGGCUUGcAGCdTsdT antis 1570-1589 10699
GCCAGUGCAGCAGCCUUCA 12699 GccAGuGcAGcAGccuucAdTsdT sense 1570-1589
10700 UGAAGGCUGCUGCACUGGC 12700 UGAAGGCUGCUGcACUGGCdTsdT antis
1571-1590 10701 CCAGUGCAGCAGCCUUCAG 12701 ccAGuGcAGcAGccuucAGdTsdT
sense 1571-1590 10702 CUGAAGGCUGCUGCACUGG 12702
CUGAAGGCUGCUGcACUGGdTsdT antis 1589-1608 10703 GCUUUUGGUAGCAUGAAAG
12703 GcuuuuGGuAGcAuGAAAGdTsdT sense 1589-1608 10704
CUUUCAUGCUACCAAAAGC 12704 CUUUcAUGCuACcAAAAGCdTsdT antis 1595-1614
10705 GGUAGCAUGAAAGUUAGCA 12705 GGuAGcAuGAAAGuuAGcAdTsdT sense
1595-1614 10706 UGCUAACUUUCAUGCUACC 12706 UGCuAACUUUcAUGCuACCdTsdT
antis 1596-1615 10707 GUAGCAUGAAAGUUAGCAG 12707
GuAGcAuGAAAGuuAGcAGdTsdT sense 1596-1615 10708 CUGCUAACUUUCAUGCUAC
12708 CUGCuAACUUUcAUGCuACdTsdT antis 1597-1616 10709
UAGCAUGAAAGUUAGCAGA 12709 uAGcAuGAAAGuuAGcAGAdTsdT sense 1597-1616
10710 UCUGCUAACUUUCAUGCUA 12710 UCUGCuAACUUUcAUGCuAdTsdT antis
1606-1625 10711 AGUUAGCAGAGAUAAAGAU 12711 AGuuAGcAGAGAuAAAGAudTsdT
sense 1606-1625 10712 AUCUUUAUCUCUGCUAACU 12712
AUCUUuAUCUCUGCuAACUdTsdT antis 1607-1626 10713 GUUAGCAGAGAUAAAGAUG
12713 GuuAGcAGAGAuAAAGAuGdTsdT sense 1607-1626 10714
CAUCUUUAUCUCUGCUAAC 12714 cAUCUUuAUCUCUGCuAACdTsdT antis 1608-1627
10715 UUAGCAGAGAUAAAGAUGG 12715 uuAGcAGAGAuAAAGAuGGdTsdT sense
1608-1627 10716 CCAUCUUUAUCUCUGCUAA 12716 CcAUCUUuAUCUCUGCuAAdTsdT
antis 1616-1635 10717 GAUAAAGAUGGCAGCAAGG 12717
GAuAAAGAuGGcAGcAAGGdTsdT sense 1616-1635 10718 CCUUGCUGCCAUCUUUAUC
12718 CCUUGCUGCcAUCUUuAUCdTsdT antis 1617-1636 10719
AUAAAGAUGGCAGCAAGGU 12719 AuAAAGAuGGcAGcAAGGudTsdT sense 1617-1636
10720 ACCUUGCUGCCAUCUUUAU 12720 ACCUUGCUGCcAUCUUuAUdTsdT antis
1638-1657 10721 CCACAGUAGUGGCAACUCC 12721 ccAcAGuAGuGGcAAcuccdTsdT
sense 1638-1657 10722 GGAGUUGCCACUACUGUGG 12722
GGAGUUGCcACuACUGUGGdTsdT antis 1647-1666 10723 UGGCAACUCCUGGCCAGGG
12723 uGGcAAcuccuGGccAGGGdTsdT sense 1647-1666 10724
CCCUGGCCAGGAGUUGCCA 12724 CCCUGGCcAGGAGUUGCcAdTsdT antis 1657-1676
10725 UGGCCAGGGUCCUGACAGG 12725 uGGccAGGGuccuGAcAGGdTsdT sense
1657-1676 10726 CCUGUCAGGACCCUGGCCA 12726 CCUGUcAGGACCCUGGCcAdTsdT
antis 1660-1679 10727 CCAGGGUCCUGACAGGCCA 12727
ccAGGGuccuGAcAGGccAdTsdT sense 1660-1679 10728 UGGCCUGUCAGGACCCUGG
12728 UGGCCUGUcAGGACCCUGGdTsdT antis 1664-1683 10729
GGUCCUGACAGGCCACAGG 12729 GGuccuGAcAGGccAcAGGdTsdT sense 1664-1683
10730 CCUGUGGCCUGUCAGGACC 12730 CCUGUGGCCUGUcAGGACCdTsdT antis
1668-1687 10731 CUGACAGGCCACAGGAAGU 12731 cuGAcAGGccAcAGGAAGudTsdT
sense 1668-1687 10732 ACUUCCUGUGGCCUGUCAG 12732
ACUUCCUGUGGCCUGUcAGdTsdT antis 1692-1711 10733 AUACAGACACGAAAGUGAU
12733 AuAcAGAcAcGAAAGuGAudTsdT sense 1692-1711 10734
AUCACUUUCGUGUCUGUAU 12734 AUcACUUUCGUGUCUGuAUdTsdT antis 1694-1713
10735 ACAGACACGAAAGUGAUUG 12735 AcAGAcAcGAAAGuGAuuGdTsdT sense
1694-1713 10736 CAAUCACUUUCGUGUCUGU 12736 cAAUcACUUUCGUGUCUGUdTsdT
antis 1716-1735 10737 AUGGAUCAUUUGGUGUGGU 12737
AuGGAucAuuuGGuGuGGudTsdT sense 1716-1735 10738 ACCACACCAAAUGAUCCAU
12738 ACcAcACcAAAUGAUCcAUdTsdT antis 1730-1749 10739
GUGGUAUAUCAAGCCAAAC 12739 GuGGuAuAucAAGccAAAcdTsdT sense 1730-1749
10740 GUUUGGCUUGAUAUACCAC 12740 GUUUGGCUUGAuAuACcACdTsdT antis
1764-1783 10741 AACUGGUUGCCAUCAAGAA 12741 AAcuGGuuGccAucAAGAAdTsdT
sense 1764-1783 10742 UUCUUGAUGGCAACCAGUU 12742
UUCUUGAUGGcAACcAGUUdTsdT antis 1765-1784 10743 ACUGGUUGCCAUCAAGAAA
12743 AcuGGuuGccAucAAGAAAdTsdT sense 1765-1784 10744
UUUCUUGAUGGCAACCAGU 12744 UUUCUUGAUGGcAACcAGUdTsdT antis 1766-1785
10745 CUGGUUGCCAUCAAGAAAG 12745 cuGGuuGccAucAAGAAAGdTsdT sense
1766-1785 10746 CUUUCUUGAUGGCAACCAG 12746 CUUUCUUGAUGGcAACcAGdTsdT
antis 1771-1790 10747 UGCCAUCAAGAAAGUUCUA 12747
uGccAucAAGAAAGuucuAdTsdT sense 1771-1790 10748 UAGAACUUUCUUGAUGGCA
12748 uAGAACUUUCUUGAUGGcAdTsdT antis 1777-1796 10749
CAAGAAAGUUCUACAGGAC 12749 cAAGAAAGuucuAcAGGAcdTsdT sense 1777-1796
10750 GUCCUGUAGAACUUUCUUG 12750 GUCCUGuAGAACUUUCUUGdTsdT antis
1811-1830 10751 CGAGAGCUCCAGAUCAUGA 12751 cGAGAGcuccAGAucAuGAdTsdT
sense 1811-1830 10752 UCAUGAUCUGGAGCUCUCG 12752
UcAUGAUCUGGAGCUCUCGdTsdT antis 1814-1833 10753 GAGCUCCAGAUCAUGAGAA
12753 GAGcuccAGAucAuGAGAAdTsdT sense 1814-1833 10754
UUCUCAUGAUCUGGAGCUC 12754 UUCUcAUGAUCUGGAGCUCdTsdT antis 1835-1854
10755 CUAGACCACUGUAACAUAG 12755 cuAGAccAcuGuAAcAuAGdTsdT sense
1835-1854 10756 CUAUGUUACAGUGGUCUAG 12756 CuAUGUuAcAGUGGUCuAGdTsdT
antis 1881-1900 10757 GUGGUGAGAAGAAAGAUGA 12757
GuGGuGAGAAGAAAGAuGAdTsdT sense 1881-1900 10758 UCAUCUUUCUUCUCACCAC
12758 UcAUCUUUCUUCUcACcACdTsdT antis 1882-1901 10759
UGGUGAGAAGAAAGAUGAG 12759 uGGuGAGAAGAAAGAuGAGdTsdT sense 1882-1901
10760 CUCAUCUUUCUUCUCACCA 12760 CUcAUCUUUCUUCUcACcAdTsdT antis
1902-1921 10761 UCUACCUUAACCUGGUGCU 12761 ucuAccuuAAccuGGuGcudTsdT
sense 1902-1921 10762 AGCACCAGGUUAAGGUAGA 12762
AGcACcAGGUuAAGGuAGAdTsdT antis 1914-1933 10763 UGGUGCUGGACUAUGUUCC
12763 uGGuGcuGGAcuAuGuuccdTsdT sense 1914-1933 10764
GGAACAUAGUCCAGCACCA 12764 GGAAcAuAGUCcAGcACcAdTsdT antis 1932-1951
10765 CGGAGACAGUGUACAGAGU 12765 cGGAGAcAGuGuAcAGAGudTsdT sense
1932-1951 10766 ACUCUGUACACUGUCUCCG 12766 ACUCUGuAcACUGUCUCCGdTsdT
antis 1968-1987 10767 GAGCCAAGCAGACACUCCC 12767
GAGccAAGcAGAcAcucccdTsdT sense 1968-1987 10768 GGGAGUGUCUGCUUGGCUC
12768 GGGAGUGUCUGCUUGGCUCdTsdT antis 1969-1988 10769
AGCCAAGCAGACACUCCCU 12769 AGccAAGcAGAcAcucccudTsdT sense 1969-1988
10770 AGGGAGUGUCUGCUUGGCU 12770 AGGGAGUGUCUGCUUGGCUdTsdT antis
1976-1995 10771 CAGACACUCCCUGUGAUCU 12771 cAGAcAcucccuGuGAucudTsdT
sense 1976-1995 10772 AGAUCACAGGGAGUGUCUG 12772
AGAUcAcAGGGAGUGUCUGdTsdT antis 2002-2021 10773 GUUGUAUAUGUAUCAGCUG
12773 GuuGuAuAuGuAucAGcuGdTsdT sense 2002-2021 10774
CAGCUGAUACAUAUACAAC 12774 cAGCUGAuAcAuAuAcAACdTsdT antis 2013-2032
10775 AUCAGCUGUUCAGAAGUCU 12775 AucAGcuGuucAGAAGucudTsdT sense
2013-2032 10776 AGACUUCUGAACAGCUGAU 12776 AGACUUCUGAAcAGCUGAUdTsdT
antis 2014-2033 10777 UCAGCUGUUCAGAAGUCUA 12777
ucAGcuGuucAGAAGucuAdTsdT sense 2014-2033 10778 UAGACUUCUGAACAGCUGA
12778 uAGACUUCUGAAcAGCUGAdTsdT antis 2032-2051 10779
AGCCUAUAUCCAUUCCUUU 12779 AGccuAuAuccAuuccuuudTsdT sense 2032-2051
10780 AAAGGAAUGGAUAUAGGCU 12780 AAAGGAAUGGAuAuAGGCUdTsdT antis
2033-2052 10781 GCCUAUAUCCAUUCCUUUG 12781 GccuAuAuccAuuccuuuGdTsdT
sense 2033-2052 10782 CAAAGGAAUGGAUAUAGGC 12782
cAAAGGAAUGGAuAuAGGCdTsdT antis 2034-2053 10783 CCUAUAUCCAUUCCUUUGG
12783 ccuAuAuccAuuccuuuGGdTsdT sense 2034-2053 10784
CCAAAGGAAUGGAUAUAGG 12784 CcAAAGGAAUGGAuAuAGGdTsdT antis 2037-2056
10785 AUAUCCAUUCCUUUGGAAU 12785 AuAuccAuuccuuuGGAAudTsdT sense
2037-2056 10786 AUUCCAAAGGAAUGGAUAU 12786 AUUCcAAAGGAAUGGAuAUdTsdT
antis 2038-2057 10787 UAUCCAUUCCUUUGGAAUC 12787
uAuccAuuccuuuGGAAucdTsdT sense 2038-2057 10788 GAUUCCAAAGGAAUGGAUA
12788 GAUUCcAAAGGAAUGGAuAdTsdT antis 2041-2060 10789
CCAUUCCUUUGGAAUCUGC 12789 ccAuuccuuuGGAAucuGcdTsdT sense 2041-2060
10790 GCAGAUUCCAAAGGAAUGG 12790 GcAGAUUCcAAAGGAAUGGdTsdT antis
2045-2064 10791 UCCUUUGGAAUCUGCCAUC 12791 uccuuuGGAAucuGccAucdTsdT
sense 2045-2064 10792 GAUGGCAGAUUCCAAAGGA 12792
GAUGGcAGAUUCcAAAGGAdTsdT antis 2069-2088 10793 AUUAAACCACAGAACCUCU
12793 AuuAAAccAcAGAAccucudTsdT sense 2069-2088 10794
AGAGGUUCUGUGGUUUAAU 12794 AGAGGUUCUGUGGUUuAAUdTsdT antis 2110-2129
10795 AUUAAAACUCUGUGACUUU 12795 AuuAAAAcucuGuGAcuuudTsdT sense
2110-2129 10796 AAAGUCACAGAGUUUUAAU 12796 AAAGUcAcAGAGUUUuAAUdTsdT
antis 2111-2130 10797 UUAAAACUCUGUGACUUUG 12797
uuAAAAcucuGuGAcuuuGdTsdT sense 2111-2130 10798 CAAAGUCACAGAGUUUUAA
12798 cAAAGUcAcAGAGUUUuAAdTsdT antis 2114-2133 10799
AAACUCUGUGACUUUGGAA 12799 AAAcucuGuGAcuuuGGAAdTsdT sense 2114-2133
10800 UUCCAAAGUCACAGAGUUU 12800 UUCcAAAGUcAcAGAGUUUdTsdT antis
2121-2140 10801 GUGACUUUGGAAGUGCAAA 12801 GuGAcuuuGGAAGuGcAAAdTsdT
sense 2121-2140 10802 UUUGCACUUCCAAAGUCAC 12802
UUUGcACUUCcAAAGUcACdTsdT antis 2122-2141 10803 UGACUUUGGAAGUGCAAAG
12803 uGAcuuuGGAAGuGcAAAGdTsdT sense 2122-2141 10804
CUUUGCACUUCCAAAGUCA 12804 CUUUGcACUUCcAAAGUcAdTsdT antis 2127-2146
10805 UUGGAAGUGCAAAGCAGCU 12805 uuGGAAGuGcAAAGcAGcudTsdT sense
2127-2146 10806 AGCUGCUUUGCACUUCCAA 12806 AGCUGCUUUGcACUUCcAAdTsdT
antis 2128-2147 10807 UGGAAGUGCAAAGCAGCUG 12807
uGGAAGuGcAAAGcAGcuGdTsdT sense 2128-2147 10808 CAGCUGCUUUGCACUUCCA
12808 cAGCUGCUUUGcACUUCcAdTsdT antis 2130-2149 10809
GAAGUGCAAAGCAGCUGGU 12809 GAAGuGcAAAGcAGcuGGudTsdT sense 2130-2149
10810 ACCAGCUGCUUUGCACUUC 12810 ACcAGCUGCUUUGcACUUCdTsdT antis
2144-2163 10811 CUGGUCCGAGGAGAGCCCA 12811 cuGGuccGAGGAGAGcccAdTsdT
sense 2144-2163 10812 UGGGCUCUCCUCGGACCAG 12812
UGGGCUCUCCUCGGACcAGdTsdT antis 2145-2164 10813 UGGUCCGAGGAGAGCCCAA
12813 uGGuccGAGGAGAGcccAAdTsdT sense 2145-2164 10814
UUGGGCUCUCCUCGGACCA 12814 UUGGGCUCUCCUCGGACcAdTsdT antis 2152-2171
10815 AGGAGAGCCCAAUGUUUCA 12815 AGGAGAGcccAAuGuuucAdTsdT sense
2152-2171 10816 UGAAACAUUGGGCUCUCCU 12816 UGAAAcAUUGGGCUCUCCUdTsdT
antis 2173-2192 10817 UAUCUGUUCUCGGUACUAC 12817
uAucuGuucucGGuAcuAcdTsdT sense 2173-2192 10818 GUAGUACCGAGAACAGAUA
12818 GuAGuACCGAGAAcAGAuAdTsdT antis 2244-2263 10819
UAUGGUCUGCAGGCUGUGU 12819 uAuGGucuGcAGGcuGuGudTsdT sense 2244-2263
10820 ACACAGCCUGCAGACCAUA 12820 AcAcAGCCUGcAGACcAuAdTsdT antis
2293-2312 10821 AUUUCCUGGGGACAGUGGU 12821 AuuuccuGGGGAcAGuGGudTsdT
sense 2293-2312 10822 ACCACUGUCCCCAGGAAAU 12822
ACcACUGUCCCcAGGAAAUdTsdT antis 2296-2315 10823 UCCUGGGGACAGUGGUGUG
12823 uccuGGGGAcAGuGGuGuGdTsdT sense 2296-2315 10824
CACACCACUGUCCCCAGGA 12824 cAcACcACUGUCCCcAGGAdTsdT antis 2297-2316
10825 CCUGGGGACAGUGGUGUGG 12825 ccuGGGGAcAGuGGuGuGGdTsdT sense
2297-2316 10826 CCACACCACUGUCCCCAGG 12826 CcAcACcACUGUCCCcAGGdTsdT
antis 2320-2339 10827 GUUGGUGGAAAUAAUAAAG 12827
GuuGGuGGAAAuAAuAAAGdTsdT sense 2320-2339 10828 CUUUAUUAUUUCCACCAAC
12828 CUUuAUuAUUUCcACcAACdTsdT antis 2321-2340 10829
UUGGUGGAAAUAAUAAAGG 12829 uuGGuGGAAAuAAuAAAGGdTsdT sense 2321-2340
10830 CCUUUAUUAUUUCCACCAA 12830 CCUUuAUuAUUUCcACcAAdTsdT antis
2322-2341 10831 UGGUGGAAAUAAUAAAGGU 12831 uGGuGGAAAuAAuAAAGGudTsdT
sense 2322-2341 10832 ACCUUUAUUAUUUCCACCA 12832
ACCUUuAUuAUUUCcACcAdTsdT antis 2348-2367 10833 ACACCAACAAGGGAGCAAA
12833 AcAccAAcAAGGGAGcAAAdTsdT sense 2348-2367 10834
UUUGCUCCCUUGUUGGUGU 12834 UUUGCUCCCUUGUUGGUGUdTsdT antis 2349-2368
10835 CACCAACAAGGGAGCAAAU 12835 cAccAAcAAGGGAGcAAAudTsdT sense
2349-2368 10836 AUUUGCUCCCUUGUUGGUG 12836 AUUUGCUCCCUUGUUGGUGdTsdT
antis 2389-2408 10837 UACAGAAUUCAAAUUCCCU 12837
uAcAGAAuucAAAuucccudTsdT sense 2389-2408 10838 AGGGAAUUUGAAUUCUGUA
12838 AGGGAAUUUGAAUUCUGuAdTsdT antis 2414-2433 10839
AAGGCACAUCCUUGGACAA 12839 AAGGcAcAuccuuGGAcAAdTsdT sense 2414-2433
10840 UUGUCCAAGGAUGUGCCUU 12840 UUGUCcAAGGAUGUGCCUUdTsdT antis
2419-2438 10841 ACAUCCUUGGACAAAGGUC 12841 AcAuccuuGGAcAAAGGucdTsdT
sense 2419-2438 10842 GACCUUUGUCCAAGGAUGU 12842
GACCUUUGUCcAAGGAUGUdTsdT antis 2429-2448 10843 ACAAAGGUCUUCCGGCCCC
12843 AcAAAGGucuuccGGccccdTsdT sense 2429-2448 10844
GGGGCCGGAAGACCUUUGU 12844 GGGGCCGGAAGACCUUUGUdTsdT antis 2460-2479
10845 AGGCAAUUGCACUGUGCAG 12845 AGGcAAuuGcAcuGuGcAGdTsdT sense
2460-2479 10846 CUGCACAGUGCAAUUGCCU 12846 CUGcAcAGUGcAAUUGCCUdTsdT
antis 2474-2493 10847 UGCAGCCGUCUGCUGGAGU 12847
uGcAGccGucuGcuGGAGudTsdT sense 2474-2493 10848 ACUCCAGCAGACGGCUGCA
12848 ACUCcAGcAGACGGCUGcAdTsdT antis 2480-2499 10849
CGUCUGCUGGAGUACACAC 12849 cGucuGcuGGAGuAcAcAcdTsdT sense 2480-2499
10850 GUGUGUACUCCAGCAGACG 12850 GUGUGuACUCcAGcAGACGdTsdT antis
2481-2500 10851 GUCUGCUGGAGUACACACC 12851 GucuGcuGGAGuAcAcAccdTsdT
sense 2481-2500 10852 GGUGUGUACUCCAGCAGAC 12852
GGUGUGuACUCcAGcAGACdTsdT antis 2511-2530 10853 UAACACCACUGGAAGCUUG
12853 uAAcAccAcuGGAAGcuuGdTsdT sense 2511-2530 10854
CAAGCUUCCAGUGGUGUUA 12854 cAAGCUUCcAGUGGUGUuAdTsdT antis 1540-1559
10855 GAGAACCACCUCCUUUGCG 12855 GAGAAccAccuccuuuGcGdTsdT sense
1540-1559 10856 CGCAAAGGAGGUGGUUCUC 12856 CGcAAAGGAGGUGGUUCUCdTsdT
antis 1883-1902 10857 GGUGAGAAGAAAGAUGAGG 12857
GGuGAGAAGAAAGAuGAGGdTsdT sense 1883-1902 10858 CCUCAUCUUUCUUCUCACC
12858 CCUcAUCUUUCUUCUcACCdTsdT antis 2044-2063 10859
UUCCUUUGGAAUCUGCCAU 12859 uuccuuuGGAAucuGccAudTsdT sense 2044-2063
10860 AUGGCAGAUUCCAAAGGAA 12860 AUGGcAGAUUCcAAAGGAAdTsdT antis
2205-2224 10861 UGAUCUUUGGAGCCACUGA 12861 uGAucuuuGGAGccAcuGAdTsdT
sense
2205-2224 10862 UCAGUGGCUCCAAAGAUCA 12862 UcAGUGGCUCcAAAGAUcAdTsdT
antis 2331-2350 10863 UAAUAAAGGUCCUAGGAAC 12863
uAAuAAAGGuccuAGGAAcdTsdT sense 2331-2350 10864 GUUCCUAGGACCUUUAUUA
12864 GUUCCuAGGACCUUuAUuAdTsdT antis 2384-2403 10865
AAUUAUACAGAAUUCAAAU 12865 AAuuAuAcAGAAuucAAAudTsdT sense 2384-2403
10866 AUUUGAAUUCUGUAUAAUU 12866 AUUUGAAUUCUGuAuAAUUdTsdT antis
1557-1576 10867 CGGAGAGCUGCAAGCCAGU 12867 cGGAGAGcuGcAAGccAGudTsdT
sense 1557-1576 10868 ACUGGCUUGCAGCUCUCCG 12868
ACUGGCUUGcAGCUCUCCGdTsdT antis 1567-1586 10869 CAAGCCAGUGCAGCAGCCU
12869 cAAGccAGuGcAGcAGccudTsdT sense 1567-1586 10870
AGGCUGCUGCACUGGCUUG 12870 AGGCUGCUGcACUGGCUUGdTsdT antis 1568-1587
10871 AAGCCAGUGCAGCAGCCUU 12871 AAGccAGuGcAGcAGccuudTsdT sense
1568-1587 10872 AAGGCUGCUGCACUGGCUU 12872 AAGGCUGCUGcACUGGCUUdTsdT
antis 1580-1599 10873 CAGCCUUCAGCUUUUGGUA 12873
cAGccuucAGcuuuuGGuAdTsdT sense 1580-1599 10874 UACCAAAAGCUGAAGGCUG
12874 uACcAAAAGCUGAAGGCUGdTsdT antis 1583-1602 10875
CCUUCAGCUUUUGGUAGCA 12875 ccuucAGcuuuuGGuAGcAdTsdT sense 1583-1602
10876 UGCUACCAAAAGCUGAAGG 12876 UGCuACcAAAAGCUGAAGGdTsdT antis
1590-1609 10877 CUUUUGGUAGCAUGAAAGU 12877 cuuuuGGuAGcAuGAAAGudTsdT
sense 1590-1609 10878 ACUUUCAUGCUACCAAAAG 12878
ACUUUcAUGCuACcAAAAGdTsdT antis 1609-1628 10879 UAGCAGAGAUAAAGAUGGC
12879 uAGcAGAGAuAAAGAuGGcdTsdT sense 1609-1628 10880
GCCAUCUUUAUCUCUGCUA 12880 GCcAUCUUuAUCUCUGCuAdTsdT antis 1615-1634
10881 AGAUAAAGAUGGCAGCAAG 12881 AGAuAAAGAuGGcAGcAAGdTsdT sense
1615-1634 10882 CUUGCUGCCAUCUUUAUCU 12882 CUUGCUGCcAUCUUuAUCUdTsdT
antis 1655-1674 10883 CCUGGCCAGGGUCCUGACA 12883
ccuGGccAGGGuccuGAcAdTsdT sense 1655-1674 10884 UGUCAGGACCCUGGCCAGG
12884 UGUcAGGACCCUGGCcAGGdTsdT antis 1671-1690 10885
ACAGGCCACAGGAAGUCAG 12885 AcAGGccAcAGGAAGucAGdTsdT sense 1671-1690
10886 CUGACUUCCUGUGGCCUGU 12886 CUGACUUCCUGUGGCCUGUdTsdT antis
1672-1691 10887 CAGGCCACAGGAAGUCAGU 12887 cAGGccAcAGGAAGucAGudTsdT
sense 1672-1691 10888 ACUGACUUCCUGUGGCCUG 12888
ACUGACUUCCUGUGGCCUGdTsdT antis 1747-1766 10889 ACUUUGUGAUUCUGGAGAA
12889 AcuuuGuGAuucuGGAGAAdTsdT sense 1747-1766 10890
UUCUCCAGAAUCACAAAGU 12890 UUCUCcAGAAUcAcAAAGUdTsdT antis 1748-1767
10891 CUUUGUGAUUCUGGAGAAC 12891 cuuuGuGAuucuGGAGAAcdTsdT sense
1748-1767 10892 GUUCUCCAGAAUCACAAAG 12892 GUUCUCcAGAAUcAcAAAGdTsdT
antis 1750-1769 10893 UUGUGAUUCUGGAGAACUG 12893
uuGuGAuucuGGAGAAcuGdTsdT sense 1750-1769 10894 CAGUUCUCCAGAAUCACAA
12894 cAGUUCUCcAGAAUcAcAAdTsdT antis 1751-1770 10895
UGUGAUUCUGGAGAACUGG 12895 uGuGAuucuGGAGAAcuGGdTsdT sense 1751-1770
10896 CCAGUUCUCCAGAAUCACA 12896 CcAGUUCUCcAGAAUcAcAdTsdT antis
1752-1771 10897 GUGAUUCUGGAGAACUGGU 12897 GuGAuucuGGAGAAcuGGudTsdT
sense 1752-1771 10898 ACCAGUUCUCCAGAAUCAC 12898
ACcAGUUCUCcAGAAUcACdTsdT antis 1753-1772 10899 UGAUUCUGGAGAACUGGUU
12899 uGAuucuGGAGAAcuGGuudTsdT sense 1753-1772 10900
AACCAGUUCUCCAGAAUCA 12900 AACcAGUUCUCcAGAAUcAdTsdT antis 2117-2136
10901 CUCUGUGACUUUGGAAGUG 12901 cucuGuGAcuuuGGAAGuGdTsdT sense
2117-2136 10902 CACUUCCAAAGUCACAGAG 12902 cACUUCcAAAGUcAcAGAGdTsdT
antis 2118-2137 10903 UCUGUGACUUUGGAAGUGC 12903
ucuGuGAcuuuGGAAGuGcdTsdT sense 2118-2137 10904 GCACUUCCAAAGUCACAGA
12904 GcACUUCcAAAGUcAcAGAdTsdT antis 2148-2167 10905
UCCGAGGAGAGCCCAAUGU 12905 uccGAGGAGAGcccAAuGudTsdT sense 2148-2167
10906 ACAUUGGGCUCUCCUCGGA 12906 AcAUUGGGCUCUCCUCGGAdTsdT antis
2202-2221 10907 AGUUGAUCUUUGGAGCCAC 12907 AGuuGAucuuuGGAGccAcdTsdT
sense 2202-2221 10908 GUGGCUCCAAAGAUCAACU 12908
GUGGCUCcAAAGAUcAACUdTsdT antis 2203-2222 10909 GUUGAUCUUUGGAGCCACU
12909 GuuGAucuuuGGAGccAcudTsdT sense 2203-2222 10910
AGUGGCUCCAAAGAUCAAC 12910 AGUGGCUCcAAAGAUcAACdTsdT antis 2204-2223
10911 UUGAUCUUUGGAGCCACUG 12911 uuGAucuuuGGAGccAcuGdTsdT sense
2204-2223 10912 CAGUGGCUCCAAAGAUCAA 12912 cAGUGGCUCcAAAGAUcAAdTsdT
antis 2206-2225 10913 GAUCUUUGGAGCCACUGAU 12913
GAucuuuGGAGccAcuGAudTsdT sense 2206-2225 10914 AUCAGUGGCUCCAAAGAUC
12914 AUcAGUGGCUCcAAAGAUCdTsdT antis 2245-2264 10915
AUGGUCUGCAGGCUGUGUG 12915 AuGGucuGcAGGcuGuGuGdTsdT sense 2245-2264
10916 CACACAGCCUGCAGACCAU 12916 cAcAcAGCCUGcAGACcAUdTsdT antis
2252-2271 10917 GCAGGCUGUGUGUUGGCUG 12917 GcAGGcuGuGuGuuGGcuGdTsdT
sense 2252-2271 10918 CAGCCAACACACAGCCUGC 12918
cAGCcAAcAcAcAGCCUGCdTsdT antis 2266-2285 10919 GGCUGAAUUGUUGCUAGGA
12919 GGcuGAAuuGuuGcuAGGAdTsdT sense 2266-2285 10920
UCCUAGCAACAAUUCAGCC 12920 UCCuAGcAAcAAUUcAGCCdTsdT antis 2294-2313
10921 UUUCCUGGGGACAGUGGUG 12921 uuuccuGGGGAcAGuGGuGdTsdT sense
2294-2313 10922 CACCACUGUCCCCAGGAAA 12922 cACcACUGUCCCcAGGAAAdTsdT
antis 2295-2314 10923 UUCCUGGGGACAGUGGUGU 12923
uuccuGGGGAcAGuGGuGudTsdT sense 2295-2314 10924 ACACCACUGUCCCCAGGAA
12924 AcACcACUGUCCCcAGGAAdTsdT antis 2350-2369 10925
ACCAACAAGGGAGCAAAUU 12925 AccAAcAAGGGAGcAAAuudTsdT sense 2350-2369
10926 AAUUUGCUCCCUUGUUGGU 12926 AAUUUGCUCCCUUGUUGGUdTsdT antis
2382-2401 10927 CAAAUUAUACAGAAUUCAA 12927 cAAAuuAuAcAGAAuucAAdTsdT
sense 2382-2401 10928 UUGAAUUCUGUAUAAUUUG 12928
UUGAAUUCUGuAuAAUUUGdTsdT antis 1543-1562 10929 AACCACCUCCUUUGCGGAG
12929 AAccAccuccuuuGcGGAGdTsdT sense 1543-1562 10930
CUCCGCAAAGGAGGUGGUU 12930 CUCCGcAAAGGAGGUGGUUdTsdT antis 1544-1563
10931 ACCACCUCCUUUGCGGAGA 12931 AccAccuccuuuGcGGAGAdTsdT sense
1544-1563 10932 UCUCCGCAAAGGAGGUGGU 12932 UCUCCGcAAAGGAGGUGGUdTsdT
antis 1545-1564 10933 CCACCUCCUUUGCGGAGAG 12933
ccAccuccuuuGcGGAGAGdTsdT sense 1545-1564 10934 CUCUCCGCAAAGGAGGUGG
12934 CUCUCCGcAAAGGAGGUGGdTsdT antis 1712-1731 10935
GGAAAUGGAUCAUUUGGUG 12935 GGAAAuGGAucAuuuGGuGdTsdT sense 1712-1731
10936 CACCAAAUGAUCCAUUUCC 12936 cACcAAAUGAUCcAUUUCCdTsdT antis
1879-1898 10937 GAGUGGUGAGAAGAAAGAU 12937 GAGuGGuGAGAAGAAAGAudTsdT
sense 1879-1898 10938 AUCUUUCUUCUCACCACUC 12938
AUCUUUCUUCUcACcACUCdTsdT antis 2060-2079 10939 CAUCGAGACAUUAAACCAC
12939 cAucGAGAcAuuAAAccAcdTsdT sense 2060-2079 10940
GUGGUUUAAUGUCUCGAUG 12940 GUGGUUuAAUGUCUCGAUGdTsdT antis 2062-2081
10941 UCGAGACAUUAAACCACAG 12941 ucGAGAcAuuAAAccAcAGdTsdT sense
2062-2081 10942 CUGUGGUUUAAUGUCUCGA 12942 CUGUGGUUuAAUGUCUCGAdTsdT
antis 2061-2080 10943 AUCGAGACAUUAAACCACA 12943
AucGAGAcAuuAAAccAcAdTsdT sense 2061-2080 10944 UGUGGUUUAAUGUCUCGAU
12944 UGUGGUUuAAUGUCUCGAUdTsdT antis 2058-2077 10945
GCCAUCGAGACAUUAAACC 12945 GccAucGAGAcAuuAAAccdTsdT sense 2058-2077
10946 GGUUUAAUGUCUCGAUGGC 12946 GGUUuAAUGUCUCGAUGGCdTsdT antis
2059-2078 10947 CCAUCGAGACAUUAAACCA 12947 ccAucGAGAcAuuAAAccAdTsdT
sense 2059-2078 10948 UGGUUUAAUGUCUCGAUGG 12948
UGGUUuAAUGUCUCGAUGGdTsdT antis 1639-1658 10949 CACAGUAGUGGCAACUCCU
12949 cAcAGuAGuGGcAAcuccudTsdT sense 1639-1658 10950
AGGAGUUGCCACUACUGUG 12950 AGGAGUUGCcACuACUGUGdTsdT antis 2064-2083
10951 GAGACAUUAAACCACAGAA 12951 GAGAcAuuAAAccAcAGAAdTsdT sense
2064-2083 10952 UUCUGUGGUUUAAUGUCUC 12952 UUCUGUGGUUuAAUGUCUCdTsdT
antis 1641-1660 10953 CAGUAGUGGCAACUCCUGG 12953
cAGuAGuGGcAAcuccuGGdTsdT sense 1641-1660 10954 CCAGGAGUUGCCACUACUG
12954 CcAGGAGUUGCcACuACUGdTsdT antis 1812-1831 10955
GAGAGCUCCAGAUCAUGAG 12955 GAGAGcuccAGAucAuGAGdTsdT sense 1812-1831
10956 CUCAUGAUCUGGAGCUCUC 12956 CUcAUGAUCUGGAGCUCUCdTsdT antis
2063-2082 10957 CGAGACAUUAAACCACAGA 12957 cGAGAcAuuAAAccAcAGAdTsdT
sense 2063-2082 10958 UCUGUGGUUUAAUGUCUCG 12958
UCUGUGGUUuAAUGUCUCGdTsdT antis 2065-2084 10959 AGACAUUAAACCACAGAAC
12959 AGAcAuuAAAccAcAGAAcdTsdT sense 2065-2084 10960
GUUCUGUGGUUUAAUGUCU 12960 GUUCUGUGGUUuAAUGUCUdTsdT antis 2112-2131
10961 UAAAACUCUGUGACUUUGG 12961 uAAAAcucuGuGAcuuuGGdTsdT sense
2112-2131 10962 CCAAAGUCACAGAGUUUUA 12962 CcAAAGUcAcAGAGUUUuAdTsdT
antis 2119-2138 10963 CUGUGACUUUGGAAGUGCA 12963
cuGuGAcuuuGGAAGuGcAdTsdT sense 2119-2138 10964 UGCACUUCCAAAGUCACAG
12964 UGcACUUCcAAAGUcAcAGdTsdT antis 2123-2142 10965
GACUUUGGAAGUGCAAAGC 12965 GAcuuuGGAAGuGcAAAGcdTsdT sense 2123-2142
10966 GCUUUGCACUUCCAAAGUC 12966 GCUUUGcACUUCcAAAGUCdTsdT antis
2131-2150 10967 AAGUGCAAAGCAGCUGGUC 12967 AAGuGcAAAGcAGcuGGucdTsdT
sense 2131-2150 10968 GACCAGCUGCUUUGCACUU 12968
GACcAGCUGCUUUGcACUUdTsdT antis 1715-1734 10969 AAUGGAUCAUUUGGUGUGG
12969 AAuGGAucAuuuGGuGuGGdTsdT sense 1715-1734 10970
CCACACCAAAUGAUCCAUU 12970 CcAcACcAAAUGAUCcAUUdTsdT antis 2482-2501
10971 UCUGCUGGAGUACACACCU 12971 ucuGcuGGAGuAcAcAccudTsdT sense
2482-2501 10972 AGGUGUGUACUCCAGCAGA 12972 AGGUGUGuACUCcAGcAGAdTsdT
antis 1714-1733 10973 AAAUGGAUCAUUUGGUGUG 12973
AAAuGGAucAuuuGGuGuGdTsdT sense 1714-1733 10974 CACACCAAAUGAUCCAUUU
12974 cAcACcAAAUGAUCcAUUUdTsdT antis 1884-1903 10975
GUGAGAAGAAAGAUGAGGU 12975 GuGAGAAGAAAGAuGAGGudTsdT sense 1884-1903
10976 ACCUCAUCUUUCUUCUCAC 12976 ACCUcAUCUUUCUUCUcACdTsdT antis
2039-2058 10977 AUCCAUUCCUUUGGAAUCU 12977 AuccAuuccuuuGGAAucudTsdT
sense 2039-2058 10978 AGAUUCCAAAGGAAUGGAU 12978
AGAUUCcAAAGGAAUGGAUdTsdT antis 2113-2132 10979 AAAACUCUGUGACUUUGGA
12979 AAAAcucuGuGAcuuuGGAdTsdT sense 2113-2132 10980
UCCAAAGUCACAGAGUUUU 12980 UCcAAAGUcAcAGAGUUUUdTsdT antis 2246-2265
10981 UGGUCUGCAGGCUGUGUGU 12981 uGGucuGcAGGcuGuGuGudTsdT sense
2246-2265 10982 ACACACAGCCUGCAGACCA 12982 AcAcAcAGCCUGcAGACcAdTsdT
antis 1713-1732 10983 GAAAUGGAUCAUUUGGUGU 12983
GAAAuGGAucAuuuGGuGudTsdT sense 1713-1732 10984 ACACCAAAUGAUCCAUUUC
12984 AcACcAAAUGAUCcAUUUCdTsdT antis
TABLE-US-00005 TABLE 4 Sequences of duplexes targeting Mouse
GSK3-alpha Target sequence start identifies first nucleotide in
target sequence in mouse GSK3-alpha mRNA NM_001031667.1. Unmodified
sense strand is identical to target sequence. Unmodified antisense
strand is complementary to target sequence. Target sequence SEQ ID
unmodified sense strand SEQ unmodified antisense strand Duplex
start NO: 5' to 3' ID NO: 5' to 3' AD-18821 670 12985
AACUGCAGAUUAUGCGUAA 12996 UUACGCAUAAUCUGCAGUU AD-18823 330 12986
GGCGGCGGGAAAGCGUCAG 12997 CUGACGCUUUCCCGCCGCC AD-18824 239 12987
GGCGCGGACCAGCUCGUUC 12998 GAACGAGCUGGUCCGCGCC AD-18825 1340 12988
CCUACUGGAGUACACGCCA 12999 UGGCGUGUACUCCAGUAGG AD-18826 1342 12989
UACUGGAGUACACGCCAUC 13000 GAUGGCGUGUACUCCAGUA AD-18827 1073 12990
CACAGAUUACACCUCGUCC 13001 GGACGAGGUGUAAUCUGUG AD-18828 1236 12991
CCUAACUAUACGGAGUUCA 13002 UGAACUCCGUAUAGUUAGG AD-18829 435 12992
GCGGGCACUAGCUUCCCGC 13003 GCGGGAAGCUAGUGCCCGC AD-18830 1231 12993
UGAACCCUAACUAUACGGA 13004 UCCGUAUAGUUAGGGUUCA AD-18831 1234 12994
ACCCUAACUAUACGGAGUU 13005 AACUCCGUAUAGUUAGGGU AD-18832 1235 12995
CCCUAACUAUACGGAGUUC 13006 GAACUCCGUAUAGUUAGGG Target SEQ sequence
ID modified sense strand SEQ ID modified antisense strand Duplex
start NO: 5' to 3' NO: 5' to 3' AD-18821-b1 670 13007
AAcuGcAGAuuAuGcGuAAdTsdT 13018 UuACGcAuAAUCUGcAGUUdTsdT AD-18823-b1
330 13008 GGcGGcGGGAAAGcGucAGdTsdT 13019 CUGACGCUUUCCCGCCGCCdTsdT
AD-18824-b1 239 13009 GGcGcGGAccAGcucGuucdTsdT 13020
GAACGAGCUGGUCCGCGCCdTsdT AD-18825-b1 1340 13010
ccuAcuGGAGuAcAcGccAdTsdT 13021 UGGCGUGuACUCcAGuAGGdTsdT AD-18826-b1
1342 13011 uAcuGGAGuAcAcGccAucdTsdT 13022 GAUGGCGUGuACUCcAGuAdTsdT
AD-18827-b1 1073 13012 cAcAGAuuAcAccucGuccdTsdT 13023
GGACGAGGUGuAAUCUGUGdTsdT AD-18828-b1 1236 13013
ccuAAcuAuAcGGAGuucAdTsdT 13024 UGAACUCCGuAuAGUuAGGdTsdT AD-18829-b1
435 13014 GcGGGcAcuAGcuucccGcdTsdT 13025 GCGGGAAGCuAGUGCCCGCdTsdT
AD-18830-b1 1231 13015 uGAAcccuAAcuAuAcGGAdTsdT 13026
UCCGuAuAGUuAGGGUUcAdTsdT AD-18831-b1 1234 13016
AcccuAAcuAuAcGGAGuudTsdT 13027 AACUCCGuAuAGUuAGGGUdTsdT AD-18832-b1
1235 13017 cccuAAcuAuAcGGAGuucdTsdT 13028
GAACUCCGuAuAGUuAGGGdTsdT
TABLE-US-00006 TABLE 5 Sequences of duplexes targeting Mouse
GSK3-beta Target sequence start identifies first nucleotide in
target sequence in mouse GSK3-beta mRNA NM_019827.6. Unmodified
sense strand is identical to target sequence. Unmodified antisense
strand is complementary to target sequence. Target SEQ sequence ID
unmodified sense strand SEQ ID unmodified antisense strand Duplex
start NO: 5' to 3' NO: 5' to 3' AD-18833 1842 13029
ACUGUAACAUAGUCCGACU 13040 AGUCGGACUAUGUUACAGU AD-18834 1843 13030
CUGUAACAUAGUCCGACUG 13041 CAGUCGGACUAUGUUACAG AD-18835 1952 13031
GCCAGACACUAUAGUCGAG 13042 CUCGACUAUAGUGUCUGGC AD-18836 1847 13032
AACAUAGUCCGACUGCGGU 13043 ACCGCAGUCGGACUAUGUU AD-18837 1838 13033
GACCACUGUAACAUAGUCC 13044 GGACUAUGUUACAGUGGUC AD-18838 1846 13034
UAACAUAGUCCGACUGCGG 13045 CCGCAGUCGGACUAUGUUA AD-18839 1849 13035
CAUAGUCCGACUGCGGUAU 13046 AUACCGCAGUCGGACUAUG AD-18841 1957 13036
ACACUAUAGUCGAGCCAAG 13047 CUUGGCUCGACUAUAGUGU AD-18842 2169 13037
CAUAUAUCUGUUCUCGGUA 13048 UACCGAGAACAGAUAUAUG AD-18843 1788 13038
UACAGGACAAGCGAUUUAA 13049 UUAAAUCGCUUGUCCUGUA AD-18844 1862 13039
ACUGUAACAUAGUCCGACU 13050 UCGAGUAGAAGAAAUACCG Target SEQ sequence
ID modified sense strand SEQ modified antisense strand Duplex start
NO: 5' to 3' ID NO: 5' to 3' AD-18833-b1 1842 13051
AcuGuAAcAuAGuccGAcudTsdT 13062 AGUCGGACuAUGUuAcAGUdTsdT AD-18834-b1
1843 13052 cuGuAAcAuAGuccGAcuGdTsdT 13063 cAGUCGGACuAUGUuAcAGdTsdT
AD-18835-b1 1952 13053 GccAGAcAcuAuAGucGAGdTsdT 13064
CUCGACuAuAGUGUCUGGCdTsdT AD-18836-b1 1847 13054
AAcAuAGuccGAcuGcGGudTsdT 13065 ACCGcAGUCGGACuAUGUUdTsdT AD-18837-b1
1838 13055 GAccAcuGuAAcAuAGuccdTsdT 13066 GGACuAUGUuAcAGUGGUCdTsdT
AD-18838-b1 1846 13056 uAAcAuAGuccGAcuGcGGdTsdT 13067
CCGcAGUCGGACuAUGUuAdTsdT AD-18839-b1 1849 13057
cAuAGuccGAcuGcGGuAudTsdT 13068 AuACCGcAGUCGGACuAUGdTsdT AD-18841-b1
1957 13058 AcAcuAuAGucGAGccAAGdTsdT 13069 CUUGGCUCGACuAuAGUGUdTsdT
AD-18842-b1 2169 13059 cAuAuAucuGuucucGGuAdTsdT 13070
uACCGAGAAcAGAuAuAUGdTsdT AD-18843-b1 1788 13060
uAcAGGAcAAGcGAuuuAAdTsdT 13071 UuAAAUCGCUUGUCCUGuAdTsdT AD-18844-b1
1862 13061 cGGuAuuucuucuAcucGAdTsdT 13072
UCGAGuAGAAGAAAuACCGdTsdT
TABLE-US-00007 TABLE 6 Sequences of duplexes targeting Human
GSK3-alpha Target sequence start identifies first nucleotide in
target sequence in human GSK3-alpha mRNA NM_002093. Unmodified
sense strand is identical to target sequence. Unmodified antisense
strand is complementary to target sequence. Target sequence SEQ ID
unmodified sense strand SEQ ID unmodified antisense strand Duplex
start NO: 5' to 3' NO: 5' to 3' huGSKA-1 1273 13073
AGCUCCAGAUCAUGAGAAA 13081 UUUCUCAUGAUCUGGAGCU huGSKA-2 1979 13074
UCUGCUGGAGUAUACACCA 13082 UGGUGUAUACUCCAGCAGA huGSKA-3 1981 13075
UGCUGGAGUAUACACCAAC 13083 GUUGGUGUAUACUCCAGCA huGSKA-4 1676 13076
CACUGAUUAUACCUCUAGU 13084 ACUAGAGGUAUAAUCAGUG huGSKA-5 1839 13077
CCAAACUACACAGAAUUUA 13085 UAAAUUCUGUGUAGUUUGG huGSKA-6 1834 13078
UGAACCCAAACUACACAGA 13086 UCUGUGUAGUUUGGGUUCA huGSKA-7 1837 13079
ACCCAAACUACACAGAAUU 13087 AAUUCUGUGUAGUUUGGGU huGSKA-8 1838 13080
CCCAAACUACACAGAAUUU 13088 AAAUUCUGUGUAGUUUGGG Human GSK alpha
duplexes correspond to the mouse GSK alpha duplexes as follows:
Mouse duplex Human duplex AD-18821 huGSKA-1 AD-18825 huGSKA-2
AD-18826 huGSKA-3 AD-18827 huGSKA-4 AD-18828 huGSKA-5 AD-18830
huGSKA-6 AD-18831 huGSKA-7 AD-18832 huGSKA-8
TABLE-US-00008 TABLE 7 Sequences of duplexes targeting Human
GSK3-beta Target sequence start identifies first nucleotide in
target sequence in human GSK3-beta mRNA NM_019884. Unmodified sense
strand is identical to target sequence. Unmodified antisense strand
is complementary to target sequence. Target sequence SEQ unmodified
sense strand SEQ unmodified antisense strand Duplex start ID NO: 5'
to 3' ID NO: 5' to 3' huGSKB-1 625 13088 ACUGCAAUAUUGUGAGGCU 13099
AGCCUCACAAUAUUGCAGU huGSKB-2 626 13089 CUGCAAUAUUGUGAGGCUG 13100
CAGCCUCACAAUAUUGCAG huGSKB-3 735 13090 GCCCGCCACUUCACCAAGG 13101
CCUUGGUGAAGUGGCGGGC huGSKB-4 630 13091 AAUAUUGUGAGGCUGAGAU 13102
AUCUCAGCCUCACAAUAUU huGSKB-5 621 13092 GACCACUGCAAUAUUGUGA 13103
UCACAAUAUUGCAGUGGUC huGSKB-6 629 13093 CAAUAUUGUGAGGCUGAGA 13104
UCUCAGCCUCACAAUAUUG huGSKB-7 632 13094 UAUUGUGAGGCUGAGAUAC 13105
GUAUCUCAGCCUCACAAUA huGSKB-8 740 13095 CCACUUCACCAAGGCCAAG 13106
CUUGGCCUUGGUGAAGUGG huGSKB-9 952 13096 CCUACAUCUGUUCUCGCUA 13107
UAGCGAGAACAGAUGUAGG huGSKB-10 571 13097 UCCAGGACAAGAGGUUCAA 13108
UUGAACCUCUUGUCCUGGA huGSKB-11 645 13098 AGAUACUUUUUCUACUCCA 13109
UGGAGUAGAAAAAGUAUCU Human GSK beta duplexes correspond to the mouse
GSK beta duplexes as follows: Mouse Duplex Human Duplex AD-18833
huGSKB-1 AD-18834 huGSKB-2 AD-18835 huGSKB-3 AD-18836 huGSKB-4
AD-18837 huGSKB-5 AD-18838 huGSKB-6 AD-18839 huGSKB-7 AD-18841
huGSKB-8 AD-18842 huGSKB-9 AD-18843 huGSKB-10 AD-18844 huGSKB-11
Sequence CWU 0 SQTB SEQUENCE LISTING The patent application
contains a lengthy "Sequence Listing" section. A copy of the
"Sequence Listing" is available in electronic form from the USPTO
web site
(http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20110184046A1).
An electronic copy of the "Sequence Listing" will also be available
from the USPTO upon request and payment of the fee set forth in 37
CFR 1.19(b)(3).
0 SQTB SEQUENCE LISTING The patent application contains a lengthy
"Sequence Listing" section. A copy of the "Sequence Listing" is
available in electronic form from the USPTO web site
(http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20110184046A1).
An electronic copy of the "Sequence Listing" will also be available
from the USPTO upon request and payment of the fee set forth in 37
CFR 1.19(b)(3).
* * * * *
References