Systems and Methods for Expression-Based Discrimination of Distinct Clinical Disease States in Prostate Cancer

Abstract

A system for expression-based discrimination of distinct clinical disease states in prostate cancer is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated with recurrent or non-recurrent prostate cancer. The Prostate Cancer Prognostic system provides for sets of "prostate cancer prognostic" target sequences and further provides for combinations of polynucleotide probes and primers derived there from. These combinations of polynucleotide probes can be provided in solution or as an array. The combination of probes and the arrays can be used for diagnosis. The invention further provides further methods of classifying prostate cancer tissue.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of Application No. PCT/CA2009/000694 filed May 28, 2009, now pending, which claims priority benefit of U.S. Provisional Application No. 61/056,827, filed May 28, 2008, the entire contents both of which are incorporated herein by reference.

FIELD OF THE INVENTION

[0002] This invention relates to the field of diagnostics and in particular to systems and methods for classifying prostate cancer into distinct clinical disease states.

BACKGROUND

[0003] Prostate cancer is the most common malignancy affecting U.S. men, with approximately 240,000 new cases diagnosed each year. The incidence of prostate cancer is increasing, in part due to increased surveillance efforts from the application of routine molecular testing such as prostate-specific antigen (PSA). For most men, prostate cancer is a slow-growing, organ-confined or localized malignancy that poses little risk of death. The most common treatments for prostate cancer in the U.S. are surgical procedures such as radical prostatectomy, where the entire prostate is removed from the patient. This procedure on its own is highly curative for most but not all men.

[0004] The vast majority of deaths from prostate cancer occur in patients with metastasis, believed to be present already at the time of diagnosis in the form of clinically undetectable micro-metastases. In these patients, it is clear that prostatectomy alone is not curative and additional therapies such as anti-androgen or radiation therapy are required to control the spread of disease and extend the life of the patient.

[0005] Most prostatectomy patients however face uncertainty with respect to their prognosis after surgery: whether or not the initial surgery will be curative several years from the initial treatment because the current methods for assessment of the clinical risk such as the various pathological (e.g., tumor stage), histological (e.g., Gleason's), clinical (e.g., Kattan nomogram) and molecular biomarkers (e.g., PSA) are not reliable predictors of prognosis, specifically disease progression. Routine PSA testing has certainly increased surveillance and early-detection rates of prostate cancer and this has resulted in an increased number of patients being treated but not significantly decreased the mortality rate.

[0006] Despite the controversies surrounding PSA testing as a screening tool, most physicians confidently rely on PSA testing to assess pre-treatment prognosis and to monitor disease progression after initial therapy. Successive increases in PSA levels above a defined threshold value or variations thereof (i.e. `Rising-PSA`), also known as biochemical recurrence has been shown to be correlated to disease progression after first-line therapy (e.g., prostatectomy, radiation and brachytherapy). However, less than a 1/3 of patients with `rising-PSA` will eventually be diagnosed with systemic or metastatic disease and several studies have shown that after long-term follow up, the majority will never show any symptoms of disease progression aside from increases in PSA measurement. The limitations of using the PSA biomarker and the absence of additional biomarkers for predicting disease recurrence have led to the development of statistical models combining several clinical and pathological features including PSA results. Several of these `nomograms` have been shown to improve the predictive power for disease recurrence in individual patients over any single independent variable. These models (see Citation #14) are used routinely in the clinic and are currently the best available tools for prediction of outcomes, although they do not provide high levels of accuracy for groups of patients with highly similar histological/pathological features or those at `intermediate` risk of disease recurrence after prostatectomy.

[0007] The use of quantitative molecular analyses has the potential to increase the sensitivity, specificity and/or overall accuracy of disease prognosis and provide a more objective basis for determination of risk stratification as compared to conventional clinical-pathological risk models (see Citation #13). The PSA test demonstrates the deficiencies of relying on the measurement of any single biomarker in clinically heterogeneous and complex prostate cancer genomes. Therefore, genomic-based approaches measuring combinations of biomarkers or a signature of disease recurrence are currently being investigated as better surrogates for predicting disease outcome (see Citations # 1-13). For prostate cancer patients these efforts are aimed at reducing the number of unnecessary surgeries for patients without progressive disease and avoid inadvertent under-treatment for higher risk patients. To date, genomic profiling efforts to identify DNA-based (e.g., copy-number alterations, methylation changes), RNA-based (e.g., gene or non-coding RNA expression) or protein-based (e.g., protein expression or modification) signatures, useful for disease prognosis have not however resulted in widespread clinical use.

[0008] There are several key reasons explaining why prior genomic profiling methods for prostate cancer have not yet been incorporated in the clinic. These include the small sample sizes typical of individual studies, coupled with variations due to differences in study protocols, clinical heterogeneity of patients and lack of external validation data, which combined have made identifying a robust and reproducible disease signature elusive. Specifically for gene or RNA expression based prognostic models; the mitigating technological limitations include the quality and quantity of RNA that can be isolated from routine clinical samples. Routine clinical samples of prostate cancer include needle-biopsies and surgical resections that have been fixed in formalin and embedded in paraffin wax (FFPE). FFPE-derived RNA is typically degraded and fragmented to between 100-300 bp in size and without poly-A tails making it of little use for traditional 3'-biased gene expression profiling, which requires larger microgram quantities of RNA with intact poly-A tails to prime cDNA synthesis.

[0009] Furthermore, as <2% of the genome encodes for protein, traditional gene expression profiling in fact captures only a small fraction of the transcriptome and variation in expression as most RNA molecules that are transcribed are not translated into protein but serve other functional roles and non-coding RNAs are the most abundant transcript species in the genome.

[0010] This background information is provided for the purpose of making known information believed by the applicant to be of possible relevance to the present invention. No admission is necessarily intended, nor should be construed, that any of the preceding information constitutes prior art against the present invention.

SUMMARY OF THE INVENTION

[0011] An object of the present invention is to provide systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer. In accordance with one aspect of the present invention, there is provided a system for expression-based assessment of risk of prostate cancer recurrence after prostatectomy, said system comprising one or more polynucleotides, each of said polynucleotides capable of specifically hybridizing to a RNA transcript of a gene selected from the group of genes set forth in Table 3 and/or 6.

[0012] In accordance with another aspect of the present invention, there is provided a nucleic acid array for expression-based assessment of prostate cancer recurrence risk, said array comprising at least ten probes immobilized on a solid support, each of said probes being between about 15 and about 500 nucleotides in length, each of said probes being derived from a sequence corresponding to, or complementary to, a transcript of a gene selected from the group of genes set forth in Table 3 and/or 6, or a portion of said transcript.

[0013] In accordance with another aspect of the present invention, there is provided a method for expression-based assessment of prostate cancer recurrence, said method comprising: (a) determining the expression level of one or more transcripts of one or more genes in a test sample obtained from said subject to provide an expression pattern profile, said one or more genes selected from the group of genes set forth in Table 3 and/or 6, and (c) comparing said expression pattern profile with a reference expression pattern profile.

[0014] In accordance with another aspect of the present invention, there is provided a kit for characterizing the expression of one or more nucleic acid sequences depicted in SEQ ID NOs: 1-2114 comprising one or more nucleic acids selected from (a) a nucleic acid depicted in any of SEQ ID NOs: 1-2114; (b) an RNA form of any of the nucleic acids depicted in SEQ ID NOs: 1-2114; (c) a peptide nucleic acid form of any of the nucleic acids depicted in SEQ ID NOs: 1-2114; (d) a nucleic acid comprising at least 20 consecutive bases of any of (a-c); (e) a nucleic acid comprising at least 25 consecutive bases having at least 90% sequence identity to any of (a-c); or (f) a complement to any of (a-e); and optionally instructions for correlating the expression level of said one or more nucleic acid sequences with the disease state of prostate cancer tissue.

[0015] In accordance with another aspect of the present invention, there is provided an array of probe nucleic acids certified for use in expression-based assessment of prostate cancer recurrence risk, wherein said array comprises at least two different probe nucleic acids that specifically hybridize to corresponding different target nucleic acids depicted in one of SEQ ID NOs: 1-2114, an RNA form thereof, or a complement to either thereof.

[0016] In accordance with another aspect of the present invention, there is provided a device for classifying a biological sample from a prostate cancer as recurrent or non-recurrent, the device comprising means for measuring the expression level of one or more transcripts of one or more genes selected from the group of genes set forth in Table 3 and/or 6; means for correlating the expression level with a classification of prostate cancer status; and means for outputting the prostate cancer status.

[0017] In accordance with another aspect of the present invention, there is provided a computer-readable medium comprising one or more digitally-encoded expression pattern profiles representative of the level of expression of one or more transcripts of one or more genes selected from the group of genes set forth in Table 3 and/or 6, each of said one or more expression pattern profiles being associated with a value wherein each of said values is correlated with the presence of recurrent or non-recurrent prostate cancer.

BRIEF DESCRIPTION OF THE DRAWINGS

[0018] These and other features of the invention will become more apparent in the following detailed description in which reference is made to the appended drawings.

[0019] FIG. 1. A) Principle components analysis (PCA) of 2,114 RNAs identified to be differentially expressed between tumors from patients with differing clinical outcome (see Table 2 for comparisons evaluated), PCA plot of 22 prostate cancer tumors shows tight clustering of samples by clinical outcome of patients (circles, NED; diamonds, PSA; squares, SYS). B) Two-way hierarchical clustering dendrogram and expression matrix of 526 target sequences (Table 4) RNAs filtered using linear regression (p<0.01) to identify RNAs that followed either SYS>PSA>NED or NED>PSA>SYS trend in differential expression. C) Two-way hierarchical clustering dendrogram and expression matrix of 148 target sequences (Table 5), a subset of the most differentially expressed transcripts between patients with clinically significant `recurrent` (i.e., `SYS`) and `non-recurrent` (i.e., `PSA` and `NED`) disease as filtered using a t-test (p<0.001). For B) and C), sample and RNAs were optimally ordered using Pearson's correlation distance metric with complete-linkage cluster distances and the expression of each RNA in each sample was normalized in the heatmap by the number of standard deviations above (blacker) and below (whiter) the median expression value (grey) across all samples.

[0020] FIG. 2. Histograms showing distribution patient's tumor expression levels of a `metagene` generated from a linear combination of the 526 RNAs for each clinical group. The histograms bin samples with similar metagene expression values and significantly separate three modes of patient metagene scores (ANOVA, p<0.000001) corresponding to the three clinical status groups evaluated.

[0021] FIG. 3. Scatter plots summarizing the mean (.+-.standard deviation) of metagene expression values for tumor samples from patients in the three clinical status groups (NED; PSA; SYS). Metagenes were generated from a linear combinations of 6 (.tangle-solidup.), 18 (.diamond-solid.) or 20 (.box-solid.) RNAs and demonstrate highly significant differential expression between clinical groups (ANOVA, p<0.000001).

[0022] FIG. 4. Box plots showing interquartile range and distribution of `POP` scores for each clinical group using an 18-target sequence metagene (Table 7) to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between NED and PSA (*) as well as between PSA and SYS (**) clinical groups (p<7.times.10.sup.-7 and p<1.times.10.sup.-6, respectively).

[0023] FIG. 5. Box plots showing interquartile range and distribution of `POP` scores for each clinical group using a 10-target sequence metagene (Table 9) to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between `recurrent` (i.e., `SYS`) and non-recurrent (i.e., `PSA` and `NED`) patient groups (**, p<4.times.10.sup.-10).

[0024] FIG. 6. Box plots showing interquartile range and distribution of `POP` scores for each clinical group using a 41-target sequence metagene (Table 10) to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between `recurrent` (i.e., `SYS`) and non-recurrent (i.e., `PSA` and `NED`) patient groups (**, p<2.times.10.sup.-11).

[0025] FIG. 7. Box plots showing interquartile range and distribution of `POP` scores for each clinical group using a 148-target sequence metagene to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between `recurrent` (i.e., `SYS`) and non-recurrent (i.e., `PSA` and `NED`) patient groups (**, p<9.times.10.sup.-12).

DETAILED DESCRIPTION OF THE INVENTION

[0026] The present invention provides a system and method for assessing prostate cancer recurrence risk by distinguishing clinically distinct disease states in men with prostate cancer at the time of initial diagnosis or surgery. The system and methods are based on the identification of gene transcripts following a retrospective analysis of tumor samples that are differentially expressed in prostate cancer in a manner dependent on prostate cancer aggressiveness as indicated by long-term post-prostatectomy clinical outcome. These gene transcripts can be considered as a library which can be used as a resource for the identification of sets of specific target sequences ("prostate cancer prognostic sets"), which may represent the entire library of gene transcripts or a subset of the library and the detection of which is indicative of prostate cancer recurrence risk. The invention further provides for probes capable of detecting these target sequences and primers that are capable of amplifying the target sequences.

[0027] In accordance with one embodiment of the invention, the system and method for assessing prostate cancer recurrence risk are prognostic for a post surgery clinical outcome selected from no evidence of disease (`NED`), biochemical relapse (two successive increases in prostate-specific antigen levels; (`PSA`) and systemic prostate cancer systemic metastases (`SYS`).

[0028] In accordance with one embodiment of the invention, the target sequences comprised by the prostate cancer prognostic set are sequences based on or derived from the gene transcripts from the library, or a subset thereof. Such sequences are occasionally referred to herein as "probe selection regions" or "PSRs." In another embodiment of the invention, the target sequences comprised by the prostate classification set are sequences based on the gene transcripts from the library, or a subset thereof, and include both coding and non-coding sequences.

[0029] In one embodiment, the systems and methods provide for the molecular analysis of the expression levels of one or more of the target sequences as set forth in SEQ ID NOs: 1-2114 (Table 4). Increased relative expression of one or more target sequences in a `NED` Group corresponding to the sequences as set forth in SEQ ID NOs: 1-913 is indicative of or predictive of a non-recurrent form of prostate cancer and can be correlated with an increased likelihood of a long-term NED prognosis or low risk of prostate cancer recurrence. Increased relative expression of one or more target sequences in a `SYS` Group corresponding to the sequences as set forth in SEQ ID NOs: 914-2114 is indicative of or predictive of an aggressive form of prostate cancer and can be correlated with an increased likelihood of a long-term SYS prognosis or high risk of prostate cancer recurrence. Optionally, intermediate relative levels of one or more target sequences in a `PSA` Group corresponding to target sequences set forth in Table 7 is indicative of or predictive of biochemical recurrence. Subsets and combinations of these target sequences or probes complementary thereto may be used as described herein.

[0030] Before the present invention is described in further detail, it is to be understood that this invention is not limited to the particular methodology, compositions, articles or machines described, as such methods, compositions, articles or machines can, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.

DEFINITIONS

[0031] Unless defined otherwise or the context clearly dictates otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In describing the present invention, the following terms will be employed, and are intended to be defined as indicated below.

[0032] The term "polynucleotide" as used herein refers to a polymer of greater than one nucleotide in length of ribonucleic acid (RNA), deoxyribonucleic acid (DNA), hybrid RNA/DNA, modified RNA or DNA, or RNA or DNA mimetics, including peptide nucleic acids (PNAs). The polynucleotides may be single- or double-stranded. The term includes polynucleotides composed of naturally-occurring nucleobases, sugars and covalent internucleoside (backbone) linkages as well as polynucleotides having non-naturally-occurring portions which function similarly. Such modified or substituted polynucleotides are well-known in the art and for the purposes of the present invention, are referred to as "analogues."

[0033] "Complementary" or "substantially complementary" refers to the ability to hybridize or base pair between nucleotides or nucleic acids, such as, for instance, between a sensor peptide nucleic acid or polynucleotide and a target polynucleotide. Complementary nucleotides are, generally, A and T (or A and U), or C and G. Two single-stranded polynucleotides or PNAs are said to be substantially complementary when the bases of one strand, optimally aligned and compared and with appropriate insertions or deletions, pair with at least about 80% of the bases of the other strand, usually at least about 90% to 95%, and more preferably from about 98 to 100%.

[0034] Alternatively, substantial complementarity exists when a polynucleotide will hybridize under selective hybridization conditions to its complement. Typically, selective hybridization will occur when there is at least about 65% complementarity over a stretch of at least 14 to 25 bases, for example at least about 75%, or at least about 90% complementarity. See, M. Kanehisa Nucleic Acids Res. 12:203 (1984).

[0035] "Preferential binding" or "preferential hybridization" refers to the increased propensity of one polynucleotide to bind to its complement in a sample as compared to a noncomplementary polymer in the sample.

[0036] Hybridization conditions will typically include salt concentrations of less than about 1M, more usually less than about 500 mM, for example less than about 200 mM. In the case of hybridization between a peptide nucleic acid and a polynucleotide, the hybridization can be done in solutions containing little or no salt. Hybridization temperatures can be as low as 5.degree. C., but are typically greater than 22.degree. C., and more typically greater than about 30.degree. C., for example in excess of about 37.degree. C. Longer fragments may require higher hybridization temperatures for specific hybridization as is known in the art. Other factors may affect the stringency of hybridization, including base composition and length of the complementary strands, presence of organic solvents and extent of base mismatching, and the combination of parameters used is more important than the absolute measure of any one alone. Other hybridization conditions which may be controlled include buffer type and concentration, solution pH, presence and concentration of blocking reagents to decrease background binding such as repeat sequences or blocking protein solutions, detergent type(s) and concentrations, molecules such as polymers which increase the relative concentration of the polynucleotides, metal ion(s) and their concentration(s), chelator(s) and their concentrations, and other conditions known in the art.

[0037] "Multiplexing" herein refers to an assay or other analytical method in which multiple analytes can be assayed simultaneously.

[0038] A "target sequence" as used herein (also occasionally referred to as a "PSR" or "probe selection region") refers to a region of the genome against which one or more probes can be designed. As used herein, a probe is any polynucleotide capable of selectively hybridizing to a target sequence or its complement, or to an RNA version of either. A probe may comprise ribonucleotides, deoxyribonucleotides, peptide nucleic acids, and combinations thereof. A probe may optionally comprise one or more labels. In some embodiments, a probe may be used to amplify one or both strands of a target sequence or an RNA form thereof, acting as a sole primer in an amplification reaction or as a member of a set of primers.

[0039] "Having" is an open ended phrase like "comprising" and "including," and includes circumstances where additional elements are included and circumstances where they are not.

[0040] "Optional" or "optionally" means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where the event or circumstance occurs and instances in which it does not.

[0041] As used herein `NED` describes a clinically distinct disease state in which patients show no evidence of disease (`NED`) at least 5 years after surgery, `PSA` describes a clinically distinct disease state in which patients show biochemical relapse only (two successive increases in prostate-specific antigen levels but no other symptoms of disease with at least 5 years follow up after surgery; `PSA`) and `SYS` describes a clinically distinct disease state in which patients develop biochemical relapse and present with systemic prostate cancer disease or metastases (`SYS`) within five years after the initial treatment with radical prostatectomy.

[0042] As used herein, the term "about" refers to approximately a +/-10% variation from a given value. It is to be understood that such a variation is always included in any given value provided herein, whether or not it is specifically referred to.

[0043] Use of the singular forms "a," "an," and "the" include plural references unless the context clearly dictates otherwise. Thus, for example, reference to "a polynucleotide" includes a plurality of polynucleotides, reference to "a target" includes a plurality of such targets, reference to "a normalization method" includes a plurality of such methods, and the like. Additionally, use of specific plural references, such as "two," "three," etc., read on larger numbers of the same subject, unless the context clearly dictates otherwise.

[0044] Terms such as "connected," "attached," "linked" and "conjugated" are used interchangeably herein and encompass direct as well as indirect connection, attachment, linkage or conjugation unless the context clearly dictates otherwise.

[0045] Where a range of values is recited, it is to be understood that each intervening integer value, and each fraction thereof, between the recited upper and lower limits of that range is also specifically disclosed, along with each subrange between such values. The upper and lower limits of any range can independently be included in or excluded from the range, and each range where either, neither or both limits are included is also encompassed within the invention. Where a value being discussed has inherent limits, for example where a component can be present at a concentration of from 0 to 100%, or where the pH of an aqueous solution can range from 1 to 14, those inherent limits are specifically disclosed. Where a value is explicitly recited, it is to be understood that values which are about the same quantity or amount as the recited value are also within the scope of the invention, as are ranges based thereon. Where a combination is disclosed, each subcombination of the elements of that combination is also specifically disclosed and is within the scope of the invention. Conversely, where different elements or groups of elements are disclosed, combinations thereof are also disclosed. Where any element of an invention is disclosed as having a plurality of alternatives, examples of that invention in which each alternative is excluded singly or in any combination with the other alternatives are also hereby disclosed; more than one element of an invention can have such exclusions, and all combinations of elements having such exclusions are hereby disclosed.

Prostate Cancer Prognostic System

[0046] The system of the present invention is based on the identification of a library of gene and RNA transcripts that are differentially expressed in prostate cancer in a manner dependent on prostate cancer aggressiveness as indicated by the post-prostatectomy clinical outcome of the patient. For example, relative over expression of one or more of the gene transcripts in a prostate cancer sample compared to a reference sample or expression profile or signature there from may be prognostic of a clinically distinct disease outcome post-prostatectomy selected from no evidence of disease (`NED`), biochemical relapse (`PSA`) and prostate cancer disease systemic recurrence or metastases (`SYS`). The reference sample can be, for example, from prostate cancer sample(s) of one or more references subject(s) with a known post-prostatectomy clinical outcomes. The reference expression profile or signature may optionally be normalized to one or more appropriate reference gene transcripts. Alternatively or in addition to, expression of one or more of the gene transcripts in a prostate cancer sample may be compared to an expression profile or signature from normal prostate tissue.

[0047] Expression profiles or signatures from prostate cancer samples may be normalized to one or more house keeping gene transcripts such that normalized over and/or under expression of one or more of the gene transcripts in a sample may be indicative of a clinically distinct disease state or prognosis.

Prostate Prognostic Library

[0048] The Prostate Prognostic Library in accordance with the present invention comprises one or more gene or RNA transcripts whose relative and/or normalized expression is indicative of prostate cancer recurrence and which may be prognostic for post-prostatectomy clinical outcome of a patient. Exemplary RNA transcripts that showed differential expression in prostate cancer samples from patients with clinically distinct disease outcomes after initial treatment with radical prostatectomy are shown in Table 3. In one embodiment of the invention, the library comprises one or more of the gene transcripts of the genes listed in Table 3.

[0049] In one embodiment, the library comprises at least one transcript from at least one gene selected from those listed in Table 3. In one embodiment, the library comprises at least one transcript from each of at least 5 genes selected from those listed in Table 3. In another embodiment, the library comprises at least one transcript from each of at least 10 genes selected from those listed in Table 3. In a further embodiment, the library comprises at least one transcript from each of at least 15 genes selected from those listed in Table 1. In other embodiments, the library comprises at least one transcript from each of at least 20, at least 25, at least 30, at least 35, at least 40, at least 45, at least 50, at least 55, at least 60 and at least 65 genes selected from those listed in Table 3. In a further embodiment, the library comprises at least one transcript from all of the genes listed in Table 3. In a further embodiment, the library comprises at all transcripts from all of the genes listed in Table 3.

[0050] In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of [NM.sub.--001004722]; [NM.sub.--001005522]; [NM.sub.--001013671]; [NM.sub.--001033517]; [NM.sub.--183049]; [NM.sub.--212559]; 5'-3' exoribonuclease 1; A kinase (PRKA) anchor protein (yotiao) 9; AarF domain containing kinase 4; Abhydrolase domain containing 3; Aconitase 1, soluble; Actinin, alpha 1; ADAM metallopeptidase domain 19 (meltrin beta); Adaptor-related protein complex 1, gamma 2 subunit; Adenosine deaminase, RNA-specific, B2 (RED2 homolog rat); Adenylate cyclase 3; ADP-ribosylation factor GTPase activating protein 3; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); ADP-ribosylation factor-like 4D; Adrenergic, beta, receptor kinase 2; AF4/FMR2 family, member 3; Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); Anaphase promoting complex subunit 1; Ankyrin 3, node of Ranvier (ankyrin G); Ankyrin repeat domain 15; Ankyrin repeat domain 28; Annexin A1; Annexin A2; Anterior pharynx defective 1 homolog B (C. elegans); Anthrax toxin receptor 1; Antizyme inhibitor 1; Arachidonate 12-lipoxygenase, 12R type; Arginine vasopressin receptor 1A; Arginine-glutamic acid dipeptide (RE) repeats; ARP3 actin-related protein 3 homolog (yeast); Arrestin 3, retinal (X-arrestin); Arrestin domain containing 1; Aryl hydrocarbon receptor interacting protein-like 1; Aryl hydrocarbon receptor nuclear translocator; Ataxin 1; ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein; ATPase, Class I, type 8B, member 1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATP-binding cassette, sub-family F (GCN20), member 1; Autism susceptibility candidate 2; Baculoviral IAP repeat-containing 6 (apollon); Basonuclin 2; Brain-specific angiogenesis inhibitor 3; Bromodomain containing 7; Bromodomain containing 8; Bromodomain PHD finger transcription factor; BTB (POZ) domain containing 16; BTB (POZ) domain containing 7; Calcium activated nucleotidase 1; Calcium binding protein P22; Calcium channel, voltage-dependent, beta 4 subunit; Calcium channel, voltage-dependent, L type, alpha 1C subunit; Calcium channel, voltage-dependent, L type, alpha 1D subunit; Calcyclin binding protein; Calmodulin 1 (phosphorylase kinase, delta); Calsyntenin 1; Carbonyl reductase 3; Cardiolipin synthase 1; Carnitine palmitoyltransferase 1A (liver); Casein kinase 1, delta; Casein kinase 1, gamma 1; Casein kinase 1, gamma 3; Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); CD109 molecule; CD99 molecule-like 2; CDK5 regulatory subunit associated protein 2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2; Cell adhesion molecule 1; Cell division cycle and apoptosis regulator 1; Centrosomal protein 70 kDa; Chloride channel 3; Chromodomain helicase DNA binding protein 2; Chromodomain helicase DNA binding protein 6; Chromodomain protein, Y-like 2; Chromosome 1 ORF 116; Chromosome 1 ORF 52; Chromosome 10 ORF 118; Chromosome 12 ORF 30; Chromosome 13 ORF 23; Chromosome 16 ORF 45; Chromosome 18 ORF 1; Chromosome 18 ORF 1; Chromosome 18 ORF 1; Chromosome 18 ORF 1; Chromosome 18 ORF 17; Chromosome 2 ORF 3; Chromosome 20 ORF 133; Chromosome 21 ORF 25; Chromosome 21 ORF 34; Chromosome 22 ORF 13; Chromosome 3 ORF 26; Chromosome 5 ORF 3; Chromosome 5 ORF 33; Chromosome 5 ORF 35; Chromosome 5 ORF 39; Chromosome 7 ORF 13; Chromosome 7 ORF 42; Chromosome 9 ORF 3; Chromosome 9 ORF 94; Chromosome Y ORF 15B; Chymase 1, mast cell; Citrate lyase beta like; Class II, major histocompatibility complex, transactivator; C-Maf-inducing protein; Coatomer protein complex, subunit alpha; Cofilin 2 (muscle); Coiled-coil domain containing 50; Coiled-coil domain containing 7; Coiled-coil-helix-coiled-coil-helix domain containing 4; Cold shock domain containing E1, RNA-binding; Collagen, type XII, alpha 1; Complement component 1, r subcomponent-like; Core-binding factor, runt domain, alpha subunit 2; translocated to, 2; CREB binding protein (Rubinstein-Taybi syndrome); CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; CUG triplet repeat, RNA binding protein 2; Cullin 3; Cut-like 2; Cyclin F; Cyclin Y; Cysteine-rich with EGF-like domains 1; Cytochrome P450, family 4, subfamily F, polypeptide 11; Cytoplasmic FMR1 interacting protein 2; DAZ interacting protein 1-like; DCP2 decapping enzyme homolog (S. cerevisiae); DEAD box polypeptide 47; DEAD box polypeptide 5; DEAD box polypeptide 52; DEAD box polypeptide 56; Death inducer-obliterator 1; Dedicator of cytokinesis 2; DEP domain containing 1B; DEP domain containing 2; DEP domain containing 6; Development and differentiation enhancing factor 1; Diacylglycerol lipase, alpha; Diaphanous homolog 2 (Drosophila); Dickkopf homolog 3; Dihydropyrimidine dehydrogenase; Dipeptidyl-peptidase 10; Discs, large homolog 2, chapsyn-110; Dishevelled, dsh homolog 2; DnaJ (Hsp40) homolog, subfamily C, member 6; Dpy-19-like 3; Dual specificity phosphatase 5; Ectodysplasin A receptor; Ectonucleoside triphosphate diphosphohydrolase 7; EGFR-coamplified and overexpressed protein; ELL associated factor 1; Emopamil binding protein (sterol isomerase); Enabled homolog; Ephrin-A5; ER lipid raft associated 1; Erythroblast membrane-associated protein (Scianna blood group); Erythrocyte membrane protein band 4.1 like 4A; Etoposide induced 2.4 mRNA; Eukaryotic translation initiation factor 4E family member 3; FAD1 flavin adenine dinucleotide synthetase homolog; Family with sequence similarity 110, member A; Family with sequence similarity 114, member A1; Family with sequence similarity 135, member A; Family with sequence similarity 40, member A; Family with sequence similarity 80, member B; F-box and leucine-rich repeat protein 11; F-box and leucine-rich repeat protein 7; F-box protein 2; Ferritin, heavy polypeptide 1; Fibronectin type III domain containing 3A; Fibronectin type III domain containing 3B; Fibulin 1; FLJ25476 protein; FLJ41603 protein; Forkhead box J3; Forkhead box J3; Forkhead box K1; Forkhead box P1; Frizzled homolog 3; Frizzled homolog 5; G protein-coupled receptor kinase interactor 2; GABA A receptor, delta; GATA binding protein 2; GDNF family receptor alpha 2; Gelsolin (amyloidosis, Finnish type); Genethonin 1; Glucose phosphate isomerase; Glucose-fructose oxidoreductase domain containing 1; Glucosidase, beta (bile acid) 2; Glutamate dehydrogenase 1; Glutaminase; Glutamyl aminopeptidase (aminopeptidase A); Glutathione reductase

Glycogen synthase kinase 3 beta; Grainyhead-like 2; Gremlin 1, cysteine knot superfamily, homolog; GTPase activating protein (SH3 domain) binding protein 1; Hairy/enhancer-of-split related with YRPW motif 2; Heparan sulfate 6-O-sulfotransferase 3; Hermansky-Pudlak syndrome 5; Heterogeneous nuclear ribonucleoprotein C(C1/C2) Hippocalcin-like 1; Histocompatibility (minor) 13; Histone cluster 1, H3d; Histone deacetylase 6; Homeobox A1; Homeobox and leucine zipper encoding; Host cell factor C1 (VP16-accessory protein); Hyaluronan binding protein 4; Hyperpolarization activated cyclic nucleotide-gated potassium channel 3; Hypothetical gene supported by AK128346; Hypothetical LOC51149; Hypothetical protein FLJ12949; Hypothetical protein FLJ20035; Hypothetical protein FLJ20309; Hypothetical protein FLJ38482; Hypothetical protein HSPC148; Hypothetical protein LOC130576; Hypothetical protein LOC285908; Hypothetical protein LOC643155; Iduronidase, alpha-L-IKAROS family zinc finger 1 (Ikaros); IlvB (bacterial acetolactate synthase)-like; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Inositol polyphosphate-4-phosphatase, type II; Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); Integrin, alpha 6; Integrin, alpha 9; Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); Integrin, beta-like 1 (with EGF-like repeat domains); Inter-alpha (globulin) inhibitor H3; Interleukin enhancer binding factor 3, 90 kDa; Intestine-specific homeobox Intraflagellar transport 172 homolog; Janus kinase 1; Jumonji domain containing 1B; Jumonji domain containing 2B; Jumonji domain containing 2C; Kalirin, RhoGEF kinase; Kallikrein-related peptidase 2; Karyopherin alpha 3 (importin alpha 4); Keratinocyte associated protein 2; KIAA0152; KIAA0241; KIAA0319-like; KIAA0495; KIAA0562; KIAA0564 protein; KIAA1217; KIAA1244; KIAA1244; La ribonucleoprotein domain family, member 1; Lamin A/C; LATS, large tumor suppressor, homolog 2; Leiomodin 3 (fetal); Leptin receptor overlapping transcript-like 1; Leucine rich repeat containing 16; Leucine-rich repeat kinase 1; Leucine-rich repeat-containing G protein-coupled receptor 4; LIM domain 7; Major histocompatibility complex, class II, DR beta 1; Malignant fibrous histiocytoma amplified sequence 1; Maltase-glucoamylase (alpha-glucosidase); Mannosidase, alpha, class 2A, member 1; Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; MBD2-interacting zinc finger; Melanin-concentrating hormone receptor 1; Methionyl-tRNA synthetase; Methyl CpG binding protein 2; Methyl-CpG binding domain protein 5; Microcephaly, primary autosomal recessive 1; Microseminoprotein, beta-; Microtubule-associated protein 1B; Microtubule-associated protein 2; Minichromosome maintenance complex component 3 associated protein; Mitochondrial ribosomal protein S15; Mohawk homeobox; Monooxygenase, DBH-like 1; MORN repeat containing 1; Muscle RAS oncogene homolog; Muscleblind-like; Myelin protein zero-like 1; Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; Myocyte enhancer factor 2B; Myosin IF; Myosin, heavy chain 3, skeletal muscle, embryonic; N-acetylgalactosaminidase, alpha-; N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits; Nascent polypeptide-associated complex alpha subunit; NECAP endocytosis associated 2; Necdin homolog; Neural precursor cell expressed, developmentally down-regulated 9; Neuregulin 1; Neuron navigator 1; Nibrin; Nicotinamide N-methyltransferase; NIMA (never in mitosis gene a)-related kinase 6; NLR family, CARD domain containing 5; NOL1/NOP2/Sun domain family, member 3; NOL1/NOP2/Sun domain family, member 3; NOL1/NOP2/Sun domain family, member 6; Nuclear receptor coactivator 2; Nuclear receptor coactivator 6; Nuclear receptor subfamily 2, group F, member 2; Nuclear receptor subfamily 3, group C, member 2; Nuclear receptor subfamily 4, group A, member 2; Nuclear transcription factor, X-box binding-like 1; Nucleolar and coiled-body phosphoprotein 1; Overexpressed in colon carcinoma-1; PAN3 polyA specific ribonuclease subunit homolog; PAP associated domain containing 1; Paraoxonase 2; Paraspeckle component 1; PCTAIRE protein kinase 2; Peptidase D; Pericentrin (kendrin); Peroxisomal biogenesis factor 19; PHD finger protein 8; Phosphatidic acid phosphatase type 2 domain containing 3; Phosphatidylinositol 4-kinase, catalytic, alpha polypeptide; Phosphatidylinositol glycan anchor biosynthesis, class O; Phosphatidylinositol transfer protein, beta; Phosphodiesterase 4D, cAMP-specific; Phosphoglucomutase 5; Phosphoglycerate mutase family member 5; Phosphoinositide-3-kinase, class 2, beta polypeptide; Phospholipase A2, group IVB (cytosolic); Phospholipase C, beta 1 (phosphoinositide-specific); Phospholipase C, gamma 2 (phosphatidylinositol-specific); Phosphorylase kinase, beta; Plasminogen activator, tissue; Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45 kDa; Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3; Pleckstrin homology domain containing, family A member 7; Pleckstrin homology domain containing, family G (with RhoGef domain) member 3; Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1; Poly (ADP-ribose) polymerase family, member 16; Poly (ADP-ribose) polymerase family, member 2; Poly(A) polymerase alpha; Poly(A)-specific ribonuclease (deadenylation nuclease); Polymerase (DNA directed) nu; Polymerase (DNA directed), gamma 2, accessory subunit; Polymerase (RNA) II (DNA directed) polypeptide L; Polymerase (RNA) III (DNA directed) polypeptide E; Polymerase I and transcript release factor; Potassium channel tetramerisation domain containing 1; Potassium channel tetramerisation domain containing 2; Potassium channel tetramerisation domain containing 7; Potassium channel, subfamily K, member 1; Presenilin 1; PRKR interacting protein 1; Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; ProSAPiP1 protein; Prostaglandin E synthase 3 (cytosolic); Protease, serine, 2 (trypsin 2); Protein kinase, Y-linked; Protein phosphatase 1, regulatory (inhibitor) subunit 9A; Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; Protein phosphatase 4, regulatory subunit 1-like; Protein tyrosine phosphatase, non-receptor type 18 (brain-derived); Protein tyrosine phosphatase, non-receptor type 3; Protein tyrosine phosphatase, receptor type, D; Protein-O-mannosyltransferase 1; Proteolipid protein 2 (colonic epithelium-enriched); Protocadherin 7; Protocadherin gamma subfamily A, 1; PRP6 pre-mRNA processing factor 6 homolog; Putative homeodomain transcription factor 1; RAB GTPase activating protein 1-like; RAB10; RAB30; Rabaptin, RAB GTPase binding effector protein 1; RAD51-like 1; RALBP1 associated Eps domain containing 2; Rap guanine nucleotide exchange factor (GEF) 1; Rapamycin-insensitive companion of mTOR; Ras and Rab interactor 2; Receptor accessory protein 3; Reelin; Replication factor C (activator 1) 3; Replication protein A3; Rho GTPase activating protein 18; Rho guanine nucleotide exchange factor (GEF) 10-like; Rhophilin, Rho GTPase binding protein 1; Ribonuclease H2, subunit B; Ribonuclease P 14 kDa subunit; Ring finger protein 10; Ring finger protein 144; Ring finger protein 44; RNA binding motif protein 16; Roundabout, axon guidance receptor, homolog 1; Roundabout, axon guidance receptor, homolog 2; RUN domain containing 2A; Scinderin; SEC23 interacting protein; Sec61 alpha 2 subunit; Septin 11; Serine/threonine kinase 32A; Serine/threonine kinase 32C; SGT1, suppressor of G2 allele of SKP1; SH3 and PX domains 2A; Signal peptide peptidase 3; Signal transducer and activator of transcription 1, 91 kDa; Single-stranded DNA binding protein 2; Small nuclear ribonucleoprotein polypeptide N; SNF8, ESCRT-II complex subunit, homolog; Sodium channel, voltage-gated, type III, alpha subunit; Solute carrier family 1 (neutral amino acid transporter), member 5; Solute carrier family 16, member 7 (monocarboxylic acid transporter 2); Solute carrier family 2 (facilitated glucose transporter), member 11; Solute carrier family 2 (facilitated glucose transporter), member 11; Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; Solute carrier family 30 (zinc transporter), member 6; Solute carrier family 39 (zinc transporter), member 10; Solute carrier family 43, member 1; Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; SON DNA binding protein; Sortilin-related VPS10 domain containing receptor 3; Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; Spectrin repeat containing, nuclear envelope 1; Sperm associated antigen 9; Splicing factor 3a, subunit 2, 66 kDa; Splicing factor 3b, subunit 1, 155 kDa; Staphylococcal nuclease and tudor domain containing 1; Staufen, RNA binding protein, homolog 1; Suppression of tumorigenicity 7; Suppressor of variegation 4-20 homolog 1; Synapsin III; Syntaxin 3; Syntaxin 5; Tachykinin receptor 1; TAO kinase 3; TBC1 domain family, member 16; TBC1 domain family, member 19; Testis specific, 10; Tetraspanin 6; Tetratricopeptide repeat domain 23; Thioredoxin-like 2; THUMP domain containing 3; TIMELESS interacting protein; TOX high mobility group box family member 4; Trafficking protein, kinesin binding 1; Transcription factor 7-like 1 (T-cell specific, HMG-box); Transcription factor 7-like 2 (T-cell specific, HMG-box); Translocase of inner mitochondrial membrane 13 homolog; Translocated promoter region (to activated MET oncogene); Translocation associated membrane protein 2; Transmembrane 9 superfamily member 2; Transmembrane emp24 protein transport domain containing 8; Transmembrane emp24-like trafficking protein 10; Transmembrane protein 134; Transmembrane protein 18; Transmembrane protein 18; Transmembrane protein 29; Triadin; Tribbles homolog 1; Trinucleotide repeat containing 6C; Tripartite motif-containing 36; Tripartite motif-containing 61; TRNA methyltransferase 11 homolog; TruB pseudouridine (psi) synthase homolog 2; Tubby like protein 4; Tuftelin 1; Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); Tumor necrosis factor receptor superfamily, member 25; Tumor necrosis factor, alpha-induced protein 8; Tyrosine kinase 2; Ubiquinol-cytochrome c reductase core protein I; Ubiquitin specific peptidase 47; Ubiquitin specific peptidase 5 (isopeptidase T); Ubiquitin specific peptidase 8; Ubiquitin-like 7 (bone marrow stromal cell-derived); UBX domain containing 6; UDP-glucose ceramide glucosyltransferase-like 2; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2); Unc-93 homolog B1; UTP6, small subunit (SSU) processome component, homolog; Vacuolar protein sorting 8 homolog; V-akt murine thymoma viral oncogene homolog 1; V-ets erythroblastosis virus E26 oncogene homolog; Viral DNA polymerase-transactivated protein 6; WD repeat domain 33; WD repeat domain 90; Wingless-type MMTV integration site family, member 2B; WW and C2 domain containing 1; Yip1 domain family, member 3; YTH domain family, member 3; Zinc finger and BTB domain containing 10; Zinc finger and BTB domain containing 20; Zinc finger and SCAN domain containing 18; Zinc finger homeodomain 4; Zinc finger protein 14 homolog; Zinc finger protein 335; Zinc finger protein 394; Zinc finger protein 407; Zinc finger protein 608; Zinc finger protein 667; Zinc finger protein 692; Zinc finger protein 718; Zinc finger protein 721; Zinc finger, CCHC domain containing 9; Zinc finger, matrin type 1; Zinc finger, MYND domain containing 11; Zinc finger, ZZ-type containing 3; Zinc fingers and homeoboxes 2; and Zwilch, kinetochore associated, homolog.

[0051] In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Tripartite motif-containing 61; Citrate lyase beta like; Ankyrin repeat domain 15; UDP-glucose ceramide glucosyltransferase-like 2; Hypothetical protein FLJ12949; Chromosome 22 open reading frame 13; Phosphatidylinositol glycan anchor biosynthesis, class O; Solute carrier family 43, member 1; Rabaptin, RAB GTPase binding effector protein 1; Zinc finger protein 14 homolog; Hypothetical gene supported by AK128346; Adenylate cyclase 3; Phosphatidylinositol transfer protein, beta; Zinc finger protein 667; Gremlin 1, cysteine knot superfamily, homolog; Ankyrin 3, node of Ranvier (ankyrin G) and Maltase-glucoamylase (alpha-glucosidase).

[0052] In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Ankyrin repeat domain 15; Hypothetical protein FLJ12949; Solute carrier family 43, member 1; Thioredoxin-like 2; Polymerase (RNA) II (DNA directed) polypeptide L; Syntaxin 5; Leucine rich repeat containing 16; Calcium channel, voltage-dependent, beta 4 subunit; [NM.sub.--001005522]; G protein-coupled receptor kinase interactor 2; Ankyrin 3, node of Ranvier (ankyrin G); Gremlin 1, cysteine knot superfamily, homolog; Zinc finger protein 667; Hypothetical gene supported by AK128346; Transmembrane 9 superfamily member 2; Potassium channel, subfamily K, member 1; Chromodomain helicase DNA binding protein 2; Microcephaly, primary autosomal recessive 1; Chromosome 21 open reading frame 34 and Dual specificity phosphatase 5.

[0053] In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Tripartite motif-containing 61; Citrate lyase beta like; Ankyrin repeat domain 15; Ankyrin 3, node of Ranvier (ankyrin G) and Maltase-glucoamylase (alpha-glucosidase).

[0054] In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Ankyrin repeat domain 15; Hypothetical protein FLJ12949; Solute carrier family 43, member 1; Thioredoxin-like 2; Polymerase (RNA) II (DNA directed) polypeptide L; Syntaxin 5; Leucine rich repeat containing 16; Calcium channel, voltage-dependent, beta 4 subunit; [NM.sub.--001005522]; G protein-coupled receptor kinase interactor 2; Ankyrin 3, node of Ranvier (ankyrin G); Gremlin 1, cysteine knot superfamily, homolog; Zinc finger protein 667; Hypothetical gene supported by AK128346; Transmembrane 9 superfamily member 2; Potassium channel, subfamily K, member 1; Chromodomain helicase DNA binding protein 2; Chromosome 9 open reading frame 94; Chromosome 21 open reading frame 34; and Dual specificity phosphatase 5.

[0055] In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Citrate lyase beta like; Phosphodiesterase 4D, cAMP-specific; Ectodysplasin A receptor; DEP domain containing 6; Basonuclin 2; Chromosome 2 open reading frame 3; FLJ25476 protein; Staphylococcal nuclease and tudor domain containing 1; Hermansky-Pudlak syndrome 5 and Chromosome 12 open reading frame 30.

[0056] In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Tripartite motif-containing 61; Citrate lyase beta like; Adaptor-related protein complex 1, gamma 2 subunit; Kallikrein-related peptidase 2; Phosphodiesterase 4D, cAMP-specific; Cytochrome P450, family 4, subfamily F, polypeptide 11; Ectodysplasin A receptor

Phospholipase C, beta 1; KIAA1244; Paraoxonase 2; Arachidonate 12-lipoxygenase, 12R type; Cut-like 2; Chemokine (C-X-C motif) ligand 12; Rho guanine nucleotide exchange factor (GEF) 5; Olfactory receptor, family 2, subfamily A, member 4; Chromosome 19 open reading frame 42; Hypothetical gene supported by AK128346; Phosphoglucomutase 5; Hyaluronan binding protein 4; NECAP endocytosis associated 2 Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4; Signal transducer and activator of transcription 1; Chromosome 2 open reading frame 3; FLJ25476 protein; Staphylococcal nuclease and tudor domain containing 1; Transmembrane protein 18; Hermansky-Pudlak syndrome 5; Chromosome 12 open reading frame 30; Splicing factor 3b, subunit 1; Cofilin 2; Heparan sulfate 6-O-sulfotransferase 3; Enabled homolog; Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; Inositol 1,4,5-triphosphate receptor, type 1; CAP-GLY domain containing linker protein; Transglutaminase 4; MOCO sulphurase C-terminal domain containing 2; 4-hydroxyphenylpyruvate dioxygenase-like; and R3H domain containing 1.

[0057] The invention also contemplates that alternative libraries may be designed that include transcripts of one or more of the genes in Table 3, together with additional gene transcripts that have previously been shown to be associated with prostate cancer systemic progression. As is known in the art, the publication and sequence databases can be mined using a variety of search strategies to identify appropriate additional candidates for inclusion in the library. For example, currently available scientific and medical publication databases such as Medline, Current Contents, OMIM (online Mendelian inheritance in man), various Biological and Chemical Abstracts, Journal indexes, and the like can be searched using term or key-word searches, or by author, title, or other relevant search parameters. Many such databases are publicly available, and strategies and procedures for identifying publications and their contents, for example, genes, other nucleotide sequences, descriptions, indications, expression pattern, etc, are well known to those skilled in the art. Numerous databases are available through the internet for free or by subscription, see, for example, the National Center Biotechnology Information (NCBI), Infotrieve, Thomson ISI, and Science Magazine (published by the AAAS) websites. Additional or alternative publication or citation databases are also available that provide identical or similar types of information, any of which can be employed in the context of the invention. These databases can be searched for publications describing altered gene expression between recurrent and non-recurrent prostate cancer. Additional potential candidate genes may be identified by searching the above described databases for differentially expressed proteins and by identifying the nucleotide sequence encoding the differentially expressed proteins. A list of genes whose altered expression is between patients with recurrent disease and non-recurrent prostate cancer is presented in Table 6.

Prostate Cancer Prognostic Sets

[0058] A Prostate Prognostic Set comprises one or more target sequences identified within the gene transcripts in the prostate prognostic library, or a subset of these gene transcripts. The target sequences may be within the coding and/or non-coding regions of the gene transcripts. The set can comprise one or a plurality of target sequences from each gene transcript in the library, or subset thereof. The relative and/or normalized level of these target sequences in a sample is indicative of the level of expression of the particular gene transcript and thus of prostate cancer recurrence risk. For example, the relative and/or normalized expression level of one or more of the target sequences may be indicative of an recurrent form of prostate cancer and therefore prognostic for prostate cancer systemic progression while the relative and/or normalized expression level of one or more other target sequences may be indicative of a non-recurrent form of prostate cancer and therefore prognostic for a NED clinical outcome.

[0059] Accordingly, one embodiment of the present invention provides for a library or catalog of candidate target sequences derived from the transcripts (both coding and non-coding regions) of at least one gene suitable for classifying prostate cancer recurrence risk. In a further embodiment, the present invention provides for a library or catalog of candidate target sequences derived from the non-coding regions of transcripts of at least one gene suitable for classifying prostate cancer recurrence risk. In still a further embodiment, the library or catalog of candidate target sequences comprises target sequences derived from the transcripts of one or more of the genes set forth in Table 3 and/or Table 6. The library or catalog in affect provides a resource list of transcripts from which target sequences appropriate for inclusion in a Prostate Cancer Prognostic set can be derived. In one embodiment, an individual Prostate Cancer Prognostic set may comprise target sequences derived from the transcripts of one or more genes exhibiting a positive correlation with recurrent prostate cancer. In one embodiment, an individual Prostate Cancer Prognostic Set may comprise target sequences derived from the transcripts of one or more genes exhibiting a negative correlation with recurrent prostate cancer. In one embodiment, an individual Prostate Cancer Prognostic Set may comprise target sequences derived from the transcripts of two or more genes, wherein at least one gene has a transcript that exhibits a positive correlation with recurrent prostate cancer and at least one gene has a transcript that exhibits negative correlation with recurrent prostate cancer.

[0060] In one embodiment, the Prostate Cancer Prognostic Set comprises target sequences derived from the transcripts of at least one gene. In one embodiment, the Prostate Cancer Prognostic Set comprises target sequences derived from the transcripts of at least 5 genes. In another embodiment, the Prostate Cancer Prognostic set comprises target sequences derived from the transcripts of at least 10 genes. In a further embodiment, the Prostate Cancer Prognostic set comprises target sequences derived from the transcripts of at least 15 genes. In other embodiments, the Prostate Cancer Prognostic set comprises target sequences derived from the transcripts of at least 20, at least 25, at least 30, at least 35, at least 40, at least 45, at least 50, at least 55, at least 60 and at least 65 genes.

[0061] Following the identification of candidate gene transcripts, appropriate target sequences can be identified by screening for target sequences that have been annotated to be associated with each specific gene locus from a number of annotation sources including GenBank, RefSeq, Ensembl, dbEST, GENSCAN, TWINSCAN, Exoniphy, Vega, microRNAs registry and others (see Affymetrix Exon Array design note).

[0062] As part of the target sequence selection process, target sequences can be further evaluated for potential cross-hybridization against other putative transcribed sequences in the design (but not the entire genome) to identify only those target sequences that are predicted to uniquely hybridize to a single target.

[0063] Optionally, the set of target sequences that are predicted to uniquely hybridize to a single target can be further filtered using a variety of criteria including, for example, sequence length, for their mean expression levels across a wide selection of human tissues, as being representive of transcripts expressed either as novel alternative (i.e., non-consensus) exons, alternative retained introns, novel exons 5' or 3' of the gene's transcriptional start site or representing transcripts expressed in a manner antisense to the gene, amongst others.

[0064] In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3' of Replication factor C (activator 1) 3, 38 kDa; 58,123 base pair 3' of Tripartite motif-containing 61; in intron #3 of Citrate lyase beta like; in intron #2 of Ankyrin repeat domain 15; in exon #1 of UDP-glucose ceramide glucosyltransferase-like 2; in exon of #19 of Hypothetical protein FLJ12949; in intron #4 of Chromosome 22 open reading frame 13; in exon #2 of phatidylinositol glycan anchor biosynthesis, class O; in exon #15 of Solute carrier family 43, member 1; in exon #1 of Rabaptin, RAB GTPase binding effector protein 1; in intron #38 of Maltase-glucoamylase (alpha-glucosidase); in intron #23 of Ankyrin 3, node of Ranvier (ankyrin G); 71,333 base pair 3' of Gremlin 1, cysteine knot superfamily, homolog; 1,561 base pair of 3' Zinc finger protein 667; in exon #4 of Phosphatidylinositol transfer protein, beta; in intron #18 of Adenylate cyclase 3; and in exon #2 of Hypothetical gene supported by AK128346.

[0065] In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3' of Replication factor C (activator 1) 3; in intron #2 of Ankyrin repeat domain 15; in exon #19 of Hypothetical protein FLJ12949; in exon #15 of Solute carrier family 43, member 1; 313,721 base pair 3' of Thioredoxin-like 2; in exon #2 of Polymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa; in intron #10 of Syntaxin 5; 141,389 base pair 5' of Leucine rich repeat containing 16; in intron #2 of Calcium channel, voltage-dependent, beta 4 subunit; 5,474 base pair 5' of [NM.sub.--001005522]; in intron #14 of G protein-coupled receptor kinase interactor 2; in intron #23 of Ankyrin 3, node of Ranvier (ankyrin G); 71,333 base pair 3' of Gremlin 1, cysteine knot superfamily, homolog; 1,561 base pair of 3' of Zinc finger protein 667; in exon #2 of Hypothetical gene supported by AK128346; in intron #11 of Transmembrane 9 superfamily member 2; in intron #1 of Potassium channel, subfamily K, member 1; in intron #2 of Chromodomain helicase DNA binding protein 2; 22,184 base pair 5' of Microcephaly, primary autosomal recessive 1; in intron #4 of Chromosome 21 open reading frame 34; and in intron #2 of Dual specificity phosphatase 5.

[0066] In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3' of Replication factor C (activator 1) 3, 38 kDa; 58,123 base pair 3' of Tripartite motif-containing 61; in intron #3 of Citrate lyase beta like; in intron #2 of Ankyrin repeat domain 15; in intron #38 of Maltase-glucoamylase (alpha-glucosidase); and in intron #23 of Ankyrin 3, node of Ranvier (ankyrin G).

[0067] In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3' of Replication factor C (activator 1) 3, 38 kDa; in intron #2 of Ankyrin repeat domain 15; in exon #19 of Hypothetical protein FLJ12949; in exon #15 of Solute carrier family 43, member 1; 313,721 base pair 3' of Thioredoxin-like 2; in exon #2 of Polymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa; in intron #10 of Syntaxin 5; 141,389 base pair 5' of Leucine rich repeat containing 16; in intron #2 of Calcium channel, voltage-dependent, beta 4 subunit; 5,474 base pair 5' of [NM.sub.--001005522]; in intron #14 of G protein-coupled receptor kinase interactor 2; in intron #2 of Ankyrin 3, node of Ranvier (ankyrin G); 71,333 base pair of 3' Gremlin 1, cysteine knot superfamily; 1,561 base pair 3' of Zinc finger protein 667; in exon #2 of Hypothetical gene supported by AK128346; in intron #11 of Transmembrane 9 superfamily member 2; in intron #1 of Potassium channel, subfamily K, member 1; in intron #2 of Chromodomain helicase DNA binding protein 2; in exon #8 of Chromosome 9 open reading frame 94; in intron #4 of Chromosome 21 open reading frame 34; and

in intron #2 of Dual specificity phosphatase 5.

[0068] In one embodiment, the Prostate Classification Set comprises target sequences derived from in intron #3 of Citrate lyase beta like; 210,560 base pair 5' of Phosphodiesterase 4D; 189,722 base pair 5' of Ectodysplasin A receptor; 3,510 base pair 3' of DEP domain containing 6; in exon #6 of Basonuclin 2; in intron #1 of Chromosome 2 open reading frame 3; in intron #1 of FLJ25476 protein; in intron #10 of Staphylococcal nuclease and tudor domain containing 1; in exon #22 of Hermansky-Pudlak syndrome 5; and in exon #24 of Chromosome 12 open reading frame 30.

[0069] In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3' of Replication factor C (activator 1) 3, 38 kDa; 58,123 base pair 3' of Tripartite motif-containing 61; in intron #3 of Citrate lyase beta like; in intron #1 of Adaptor-related protein complex 1, gamma 2 subunit; in intron #2 of Kallikrein-related peptidase 2; 210,560 base pair 5' of Phosphodiesterase 4D; 3,508 base pair 3' of Cytochrome P450, family 4, subfamily F, polypeptide 11; 189,722 base pair 5' of Ectodysplasin A receptor; in intron #2 of Phospholipase C, beta 1; in intron #10 of KIAA1244; in intron #2 of Paraoxonase 2; 11,235 base pair 3' of Arachidonate 12-lipoxygenase, 12R type; in exon #22 of Cut-like 2; 143,098 base pair 5' of Chemokine (C-X-C motif) ligand 12; in intron #6 of Rho guanine nucleotide exchange factor (GEF) 5; 15,057 base pair 5' of Olfactory receptor, family 2, subfamily A, member 4; 6,025 base pair 3' of Chromosome 19 open reading frame 42; in exon #2 of Hypothetical gene supported by AK128346; in exon #11 of Phosphoglucomutase 5; in exon #9 of Hyaluronan binding protein 4; in exon #8 of NECAP endocytosis associated 2; in intron #20 of Myeloid/lymphoid or mixed-lineage leukemia; 1,558 base pair 3' of Signal transducer and activator of transcription; in intron #1 of Chromosome 2 open reading frame 3; in intron #1 of FLJ25476 protein; in intron #10 of Staphylococcal nuclease and tudor domain containing 1; 84,468 base pair 3' of Transmembrane protein 18; in exon #22 of Hermansky-Pudlak syndrome 5; in exon #24 of Chromosome 12 open reading frame 30; 95,745 base pair of 3' Splicing factor 3b, subunit 1; in exon #4 of Cofilin 2; in intron #1 of Heparan sulfate 6-O-sulfotransferase 3; in intron #1 of Enabled homolog; in intron #2 of Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; in intron #8 of Solute carrier family 24, member 3; 32,382 base pair 3' of Inositol 1,4,5-triphosphate receptor, type 1; in intron #9 of CAP-GLY domain containing linker protein 1; in exon #14 of Transglutaminase 4; in intron #4 of MOCO sulphurase C-terminal domain containing 2; 21,555 base pair 5' of 4 hydroxyphenylpyruvate dioxygenase-like; and in exon #26 of R3H domain containing 1.

[0070] In one embodiment, the potential set of target sequences can be filtered for their expression levels using the multi-tissue expression data made publicly available by Affymetrix at (http://www.affymetrix.com/stipport/technical/sample_data/exon_array_data- .affx) such that probes with, for example, elevated expression across numerous tissues (non-specific) or no expression in prostate tissue can be excluded.

Validation of Target Sequences

[0071] Following in silico selection of target sequences, each target sequence suitable for use in the Prostate Cancer Prognostic Set may be validated to confirm differential relative or normalized expression in recurrent prostate cancer or non-recurrent prostate cancer. Validation methods are known in the art and include hybridization techniques such as microarray analysis or Northern blotting using appropriate controls, and may include one or more additional steps, such as reverse transcription, transcription, PCR, RT-PCR and the like. The validation of the target sequences using these methods is well within the abilities of a worker skilled in the art.

Minimal Expression Signature

[0072] In one embodiment, individual Prostate Cancer Prognostic Sets provide for at least a determination of a minimal expression signature, capable of distinguishing recurrent from non-recurrent forms of prostate cancer. Means for determining the appropriate number of target sequences necessary to obtain a minimal expression signature are known in the art and include the Nearest Shrunken Centroids (NSC) method.

[0073] In this method (see US 20070031873), a standardized centroid is computed for each class. This is the average gene expression for each gene in each class divided by the within-class standard deviation for that gene. Nearest centroid classification takes the gene expression profile of a new sample, and compares it to each of these class centroids. The class whose centroid that it is closest to, in squared distance, is the predicted class for that new sample. Nearest shrunken centroid classification "shrinks" each of the class centroids toward the overall centroid for all classes by an amount called the threshold. This shrinkage consists of moving the centroid towards zero by threshold, setting it equal to zero if it hits zero. For example if threshold was 2.0, a centroid of 3.2 would be shrunk to 1.2, a centroid of -3.4 would be shrunk to -1.4, and a centroid of 1.2 would be shrunk to zero. After shrinking the centroids, the new sample is classified by the usual nearest centroid rule, but using the shrunken class centroids. This shrinkage can make the classifier more accurate by reducing the effect of noisy genes and provides an automatic gene selection. In particular, if a gene is shrunk to zero for all classes, then it is eliminated from the prediction rule. Alternatively, it may be set to zero for all classes except one, and it can be learned that the high or low expression for that gene characterizes that class. The user decides on the value to use for threshold. Typically one examines a number of different choices. To guide in this choice, PAM does K-fold cross-validation for a range of threshold values. The samples are divided up at random into K roughly equally sized parts. For each part in turn, the classifier is built on the other K-1 parts then tested on the remaining part. This is done for a range of threshold values, and the cross-validated misclassification error rate is reported for each threshold value. Typically, the user would choose the threshold value giving the minimum cross-validated misclassification error rate.

[0074] Alternatively, minimal expression signatures can be established through the use of optimization algorithms such as the mean variance algorithm widely used in establishing stock portfolios. This method is described in detail in US patent publication number 20030194734. Essentially, the method calls for the establishment of a set of inputs (stocks in financial applications, expression as measured by intensity here) that will optimize the return (e.g., signal that is generated) one receives for using it while minimizing the variability of the return. In other words, the method calls for the establishment of a set of inputs (e.g., expression as measured by intensity) that will optimize the signal while minimizing variability. Many commercial software programs are available to conduct such operations. "Wagner Associates Mean-Variance Optimization Application," referred to as "Wagner Software" throughout this specification, is preferred. This software uses functions from the "Wagner Associates Mean-Variance Optimization Library" to determine an efficient frontier and optimal portfolios in the Markowitz sense is preferred. Use of this type of software requires that microarray data be transformed so that it can be treated as an input in the way stock return and risk measurements are used when the software is used for its intended financial analysis purposes.

[0075] The process of selecting a minimal expression signature can also include the application of heuristic rules. Preferably, such rules are formulated based on biology and an understanding of the technology used to produce clinical results. More preferably, they are applied to output from the optimization method. For example, the mean variance method of portfolio selection can be applied to microarray data for a number of genes differentially expressed in subjects with cancer. Output from the method would be an optimized set of genes that could include some genes that are expressed in peripheral blood as well as in diseased tissue.

[0076] Other heuristic rules can be applied that are not necessarily related to the biology in question. For example, one can apply a rule that only a prescribed percentage of the portfolio can be represented by a particular gene or group of genes. Commercially available software such as the Wagner Software readily accommodates these types of heuristics. This can be useful, for example, when factors other than accuracy and precision (e.g., anticipated licensing fees) have an impact on the desirability of including one or more genes.

[0077] In one embodiment, the Prostate Cancer Prognostic Set for obtaining a minimal expression signature comprises at least one, two, three, four, five, six, eight, 10, 15, 20, 25 or more of target sequences shown to have a positive correlation with non-recurrent prostate disease, for example those depicted in SEQ ID NOs:1-913 or a subset thereof. In another embodiment, the Prostate Cancer Prognostic Set for obtaining a minimal expression signature comprises at least one, two, three, four, five, six, eight, 10, 15, 20, 25 or more of those target sequences shown to have a positive correlation with recurrent prostate cancer, for example those depicted in of SEQ ID NOs: 914-2114, or a subset thereof. In yet another embodiment, the Prostate Cancer Prognostic Set for obtaining a minimal expression signature comprises at least one, two, three, four, five, six, eight, 10, 15, 20, 25 or more of target sequences shown to have a correlation with non-recurrent or recurrent prostate cancer, for example those depicted in SEQ ID NOs:1-2114 or a subset thereof.

[0078] In some embodiments, the Prostate Cancer Prognostic Set comprises target sequences for detecting expression products of SEQ IDs:1-2114. In some embodiments, the Prostate Cancer Prognostic Set comprises probes for detecting expression levels of sequences exhibiting positive and negative correlation with a disease status of interest are employed. For example, a combination target sequences useful in these methods were found to include those encoding RNAs corresponding to SEQ ID NOs: 1-913 (found at increased expression in prostate cancer samples from NED patients) and/or corresponding to SEQ ID NOs: 914-2114 (found at increased expression levels in prostate cancer samples from SYS patients), where intermediate levels of certain target sequences (Table 7) are observed in prostate cancer samples from PSA patients with biochemical recurrence, where the RNA expression levels are indicative of a disease state or outcome. Subgroups of these target sequences, as well as individual target sequences, have been found useful in such methods.

[0079] In some embodiments, an RNA signature corresponding to SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21 915-917, 920, 922, 928, 929, 931, 935 and 936 (the 21-RNA' signature) and/or SEQ ID NOs: 1-11, 914-920 (the `18-RNA` signature) and/or SEQ ID NOs: 1-4, 914,915) (the `6-RNA` signature) and/or SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935 and 936 (the `20-RNA` signature) and/or SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022 (the `10-RNA` signature) and/or SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402 and 1425 (the `41-RNA` signature) are formulated into a linear combination of their respective expression values for each patient generating a patient outcome predictor (`POP`) score and indicative of the disease status of the patient after prostatectomy.

[0080] Exemplary subsets and combinations of interest also include at least five, six, 10, 15, 18, 20, 23, 25, 27, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 100, 125, 150, 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 750, 1000, 1200, 1400, 1600, 1800, 2000, or all 2114 target sequences in Table 4; at least five, six, 10, 15, 18, 20, 23, 25, 27, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 100, 125, 150, 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, or all 526 target sequences in Table 7; SEQ ID NOs:1, 4, 915, 6, 916, 9, 917, 920, 922, 14, 15, 16, 928, 929, 18, 19, 931, 20, 21, 935, 936, or combinations thereof; SEQ ID NOs:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 914, 915, 916, 917, 918, 919, 920, or combinations thereof; SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935, 936 or combinations thereof; SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014, 1022 or combinations thereof; SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402, 1425 or combinations thereof; at least one, two, three, four, five or six of SEQ ID NOs:1, 4, 6, 9, 14, 15, 16, 18, 19, 20, and 21 and at least one, two, three, four, five or six of SEQ ID NOs:915, 916, 917, 920, 922, 928, 929, 931, 935, and 936; and at least one, two, three, four, five or six of SEQ ID NOs:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 at least one, two, three, four, five or six of at least one, two, three, four, five or six of SEQ ID NOs:914, 915, 916, 917, 918, 919, and 920 and at least one, two, three, four, five or six of SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935, 936; and at least one, two, three, four, five or six of SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014, 1022; and at least one, two, three, four, five or six of SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402, 1425.

[0081] Exemplary subsets of interest include those described herein, including in the examples. Exemplary combinations of interest include those utilizing one or more of the sequences listed in Tables 5, 7, 8, 9 or 10. Of particular interest are those combinations utilizing at least one sequence exhibiting positive correlation with the trait of interest, as well as those combinations utilizing at least one sequence exhibiting negative correlation with the trait of interest. Also of interest are those combinations utilizing at least two, at least three, at least four, at least five or at least six of those sequences exhibiting such a positive correlation, in combination with at least two, at least three, at least four, at least five, or at least six of those sequences exhibiting such a negative correlation. Exemplary combinations include those utilizing at least one, two, three, four, five or six of the target sequences depicted in Tables 5 and 6.

[0082] In some embodiments, increased relative expression of one or more of SEQ IDs:1-913, decreased relative expression of one or more of SEQ ID NOs:914-2114 or a combination of any thereof is indicative/predictive of the patient exhibiting no evidence of disease for at least seven years or more after surgery. In some embodiments, increased relative expression of SEQ IDs:914-2114, decreased relative expression of one or more of SEQ ID NOs:1-913 or a combination of any thereof is indicative/predictive of the patient exhibiting systemic prostate cancer. Increased or decreased expression of target sequences represented in these sequence listings, or of the target sequences described in the examples, may be utilized in the methods of the invention.

[0083] The Prostate Cancer Prognostic Set can optionally include one or more target sequences specifically derived from the transcripts of one or more housekeeping genes and/or one or more internal control target sequences and/or one or more negative control target sequences. In one embodiment, these target sequences can, for example, be used to normalize expression data. Housekeeping genes from which target sequences for inclusion in a Prostate Cancer Prognostic Set can be derived from are known in the art and include those genes in which are expressed at a constant level in normal and prostate cancer tissue.

[0084] The target sequences described herein may be used alone or in combination with each other or with other known or later identified disease markers.

Prostate Cancer Prognostic Probes/Primers

[0085] The system of the present invention provides for combinations of polynucleotide probes that are capable of detecting the target sequences of the Prostate Cancer Prognostic Sets. Individual polynucleotide probes comprise a nucleotide sequence derived from the nucleotide sequence of the target sequences or complementary sequences thereof. The nucleotide sequence of the polynucleotide probe is designed such that it corresponds to, or is complementary to the target sequences. The polynucleotide probe can specifically hybridize under either stringent or lowered stringency hybridization conditions to a region of the target sequences, to the complement thereof, or to a nucleic acid sequence (such as a cDNA) derived therefrom.

[0086] The selection of the polynucleotide probe sequences and determination of their uniqueness may be carried out in silico using techniques known in the art, for example, based on a BLASTN search of the polynucleotide sequence in question against gene sequence databases, such as the Human Genome Sequence, UniGene, dbEST or the non-redundant database at NCBI. In one embodiment of the invention, the polynucleotide probe is complementary to a region of a target mRNA derived from a target sequence in the Prostate Cancer Prognostic Set. Computer programs can also be employed to select probe sequences that will not cross hybridize or will not hybridize non-specifically.

[0087] One skilled in the art will understand that the nucleotide sequence of the polynucleotide probe need not be identical to its target sequence in order to specifically hybridize thereto. The polynucleotide probes of the present invention, therefore, comprise a nucleotide sequence that is at least about 75% identical to a region of the target gene or mRNA. In another embodiment, the nucleotide sequence of the polynucleotide probe is at least about 90% identical a region of the target gene or mRNA. In a further embodiment, the nucleotide sequence of the polynucleotide probe is at least about 95% identical to a region of the target gene or mRNA. Methods of determining sequence identity are known in the art and can be determined, for example, by using the BLASTN program of the University of Wisconsin Computer Group (GCG) software or provided on the NCBI website. The nucleotide sequence of the polynucleotide probes of the present invention may exhibit variability by differing (e.g. by nucleotide substitution, including transition or transversion) at one, two, three, four or more nucleotides from the sequence of the target gene.

[0088] Other criteria known in the art may be employed in the design of the polynucleotide probes of the present invention. For example, the probes can be designed to have <50% G content and/or between about 25% and about 70% G+C content. Strategies to optimize probe hybridization to the target nucleic acid sequence can also be included in the process of probe selection. Hybridization under particular pH, salt, and temperature conditions can be optimized by taking into account melting temperatures and by using empirical rules that correlate with desired hybridization behaviours. Computer models may be used for predicting the intensity and concentration-dependence of probe hybridization.

[0089] As is known in the art, in order to represent a unique sequence in the human genome, a probe should be at least 15 nucleotides in length. Accordingly, the polynucleotide probes of the present invention range in length from about 15 nucleotides to the full length of the target sequence or target mRNA. In one embodiment of the invention, the polynucleotide probes are at least about 15 nucleotides in length. In another embodiment, the polynucleotide probes are at least about 20 nucleotides in length. In a further embodiment, the polynucleotide probes are at least about 25 nucleotides in length. In another embodiment, the polynucleotide probes are between about 15 nucleotides and about 500 nucleotides in length. In other embodiments, the polynucleotide probes are between about 15 nucleotides and about 450 nucleotides, about 15 nucleotides and about 400 nucleotides, about 15 nucleotides and about 350 nucleotides, about 15 nucleotides and about 300 nucleotides in length.

[0090] The polynucleotide probes of a Prostate Cancer Prognostic Set can comprise RNA, DNA, RNA or DNA mimetics, or combinations thereof, and can be single-stranded or double-stranded. Thus the polynucleotide probes can be composed of naturally-occurring nucleobases, sugars and covalent internucleoside (backbone) linkages as well as polynucleotide probes having non-naturally-occurring portions which function similarly. Such modified or substituted polynucleotide probes may provide desirable properties such as, for example, enhanced affinity for a target gene and increased stability.

[0091] The system of the present invention further provides for primers and primer pairs capable of amplifying target sequences defined by the Prostate Cancer Prognostic Set, or fragments or subsequences or complements thereof. The nucleotide sequences of the Prostate Cancer Prognostic set may be provided in computer-readable media for in silico applications and as a basis for the design of appropriate primers for amplification of one or more target sequences of the Prostate Cancer Prognostic Set.

[0092] Primers based on the nucleotide sequences of target sequences can be designed for use in amplification of the target sequences. For use in amplification reactions such as PCR, a pair of primers will be used. The exact composition of the primer sequences is not critical to the invention, but for most applications the primers will hybridize to specific sequences of the Prostate Cancer Prognostic Set under stringent conditions, particularly under conditions of high stringency, as known in the art. The pairs of primers are usually chosen so as to generate an amplification product of at least about 50 nucleotides, more usually at least about 100 nucleotides. Algorithms for the selection of primer sequences are generally known, and are available in commercial software packages. These primers may be used in standard quantitative or qualitative PCR-based assays to assess transcript expression levels of RNAs defined by the Prostate Cancer Prognostic Set. Alternatively, these primers may be used in combination with probes, such as molecular beacons in amplifications using real-time PCR.

[0093] In one embodiment, the primers or primer pairs, when used in an amplification reaction, specifically amplify at least a portion of a nucleic acid depicted in one of SEQ ID NOs: 1-2114 (or subgroups thereof as set forth herein), an RNA form thereof, or a complement to either thereof.

[0094] As is known in the art, a nucleoside is a base-sugar combination and a nucleotide is a nucleoside that further includes a phosphate group covalently linked to the sugar portion of the nucleoside. In forming oligonucleotides, the phosphate groups covalently link adjacent nucleosides to one another to form a linear polymeric compound, with the normal linkage or backbone of RNA and DNA being a 3' to 5' phosphodiester linkage. Specific examples of polynucleotide probes or primers useful in this invention include oligonucleotides containing modified backbones or non-natural internucleoside linkages. As defined in this specification, oligonucleotides having modified backbones include both those that retain a phosphorus atom in the backbone and those that lack a phosphorus atom in the backbone. For the purposes of the present invention, and as sometimes referenced in the art, modified oligonucleotides that do not have a phosphorus atom in their internucleoside backbone can also be considered to be oligonucleotides.

[0095] Exemplary polynucleotide probes or primers having modified oligonucleotide backbones include, for example, those with one or more modified internucleotide linkages that are phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters, aminoalkylphosphotriesters, methyl and other alkyl phosphonates including 3'-alkylene phosphonates and chiral phosphonates, phosphinates, phosphoramidates including 3' amino phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkyl-phosphonates, thionoalkylphosphotriesters, and boranophosphates having normal 3'-5' linkages, 2'-5' linked analogs of these, and those having inverted polarity wherein the adjacent pairs of nucleoside units are linked 3'-5' to 5'-3' or 2'-5' to 5'-2'. Various salts, mixed salts and free acid forms are also included.

[0096] Exemplary modified oligonucleotide backbones that do not include a phosphorus atom are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatom and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages. Such backbones include morpholino linkages (formed in part from the sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulphone backbones; formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones; alkene containing backbones; sulphamate backbones; methyleneimino and methylenehydrazino backbones; sulphonate and sulfonamide backbones; amide backbones; and others having mixed N, O, S and CH.sub.2 component parts.

[0097] The present invention also contemplates oligonucleotide mimetics in which both the sugar and the internucleoside linkage of the nucleotide units are replaced with novel groups. The base units are maintained for hybridization with an appropriate nucleic acid target compound. An example of such an oligonucleotide mimetic, which has been shown to have excellent hybridization properties, is a peptide nucleic acid (PNA) [Nielsen et al., Science, 254:1497-1500 (1991)]. In PNA compounds, the sugar-backbone of an oligonucleotide is replaced with an amide containing backbone, in particular an aminoethylglycine backbone. The nucleobases are retained and are bound directly or indirectly to aza-nitrogen atoms of the amide portion of the backbone. The present invention also contemplates polynucleotide probes or primers comprising "locked nucleic acids" (LNAs), which are novel conformationally restricted oligonucleotide analogues containing a methylene bridge that connects the 2'-O of ribose with the 4'-C (see, Singh et al., Chem. Commun., 1998, 4:455-456). LNA and LNA analogues display very high duplex thermal stabilities with complementary DNA and RNA, stability towards 3'-exonuclease degradation, and good solubility properties. Synthesis of the LNA analogues of adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil, their oligomerization, and nucleic acid recognition properties have been described (see Koshkin et al., Tetrahedron, 1998, 54:3607-3630). Studies of mis-matched sequences show that LNA obey the Watson-Crick base pairing rules with generally improved selectivity compared to the corresponding unmodified reference strands.

[0098] LNAs form duplexes with complementary DNA or RNA or with complementary LNA, with high thermal affinities. The universality of LNA-mediated hybridization has been emphasized by the formation of exceedingly stable LNA:LNA duplexes (Koshkin et al., J. Am. Chem. Soc., 1998, 120:13252-13253). LNA:LNA hybridization was shown to be the most thermally stable nucleic acid type duplex system, and the RNA-mimicking character of LNA was established at the duplex level. Introduction of three LNA monomers (T or A) resulted in significantly increased melting points toward DNA complements.

[0099] Synthesis of 2'-amino-LNA (Singh et al., J. Org. Chem., 1998, 63, 10035-10039) and 2'-methylamino-LNA has been described and thermal stability of their duplexes with complementary RNA and DNA strands reported. Preparation of phosphorothioate-LNA and 2'-thio-LNA have also been described (Kumar et al., Bioorg. Med. Chem. Lett., 1998, 8:2219-2222).

[0100] Modified polynucleotide probes or primers may also contain one or more substituted sugar moieties. For example, oligonucleotides may comprise sugars with one of the following substituents at the 2' position: OH; F; O--, S--, or N-alkyl; O--, S--, or N-alkenyl; O--, S-- or N-alkynyl; or O-alkyl-O-alkyl, wherein the alkyl, alkenyl and alkynyl may be substituted or unsubstituted C.sub.1 to C.sub.10 alkyl or C.sub.2 to C.sub.10 alkenyl and alkynyl. Examples of such groups are: O[(CH.sub.2).sub.n O].sub.m CH.sub.3, O(CH.sub.2).sub.n OCH.sub.3, O(CH.sub.2).sub.n NH.sub.2, O(CH.sub.2).sub.n CH.sub.3, O(CH.sub.2).sub.n ONH.sub.2, and O(CH.sub.2).sub.n ON[(CH.sub.2).sub.n CH.sub.3)].sub.2, where n and m are from 1 to about 10. Alternatively, the oligonucleotides may comprise one of the following substituents at the 2' position: C.sub.1 to C.sub.10 lower alkyl, substituted lower alkyl, alkaryl, aralkyl, O-alkaryl or O-aralkyl, SH, SCH.sub.3, OCN, Cl, Br, CN, CF.sub.3, OCF.sub.3, SOCH.sub.3, SO.sub.2 CH.sub.3, ONO.sub.2, NO.sub.2, N.sub.3, NH.sub.2, heterocycloalkyl, heterocycloalkaryl, aminoalkylamino, polyalkylamino, substituted silyl, an RNA cleaving group, a reporter group, an intercalator, a group for improving the pharmacokinetic properties of an oligonucleotide, or a group for improving the pharmacodynamic properties of an oligonucleotide, and other substituents having similar properties. Specific examples include 2'-methoxyethoxy (2'-O--CH.sub.2 CH.sub.2 OCH.sub.3, also known as 2'-O-(2-methoxyethyl) or 2'-MOE) [Martin et al., Helv. Chim. Acta, 78:486-504 (1995)], 2'-dimethylaminooxyethoxy (O(CH.sub.2).sub.2 ON(CH.sub.3).sub.2 group, also known as 2'-DMAOE), 2'-methoxy (2'-O--CH.sub.3), 2'-aminopropoxy (2'-OCH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2) and 2'-fluoro (2'-F).

[0101] Similar modifications may also be made at other positions on the polynucleotide probes or primers, particularly the 3' position of the sugar on the 3' terminal nucleotide or in 2'-5' linked oligonucleotides and the 5' position of 5' terminal nucleotide. Polynucleotide probes or primers may also have sugar mimetics such as cyclobutyl moieties in place of the pentofuranosyl sugar.

[0102] Polynucleotide probes or primers may also include modifications or substitutions to the nucleobase. As used herein, "unmodified" or "natural" nucleobases include the purine bases adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U). Modified nucleobases include other synthetic and natural nucleobases such as 5-methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5-uracil (pseudouracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl and other 8-substituted adenines and guanines, 5-halo particularly 5-bromo, 5-trifluoromethyl and other 5-substituted uracils and cytosines, 7-methylguanine and 7-methyladenine, 8-azaguanine and 8-azaadenine, 7-deazaguanine and 7-deazaadenine and 3-deazaguanine and 3-deazaadenine. Further nucleobases include those disclosed in U.S. Pat. No. 3,687,808; The Concise Encyclopedia Of Polymer Science And Engineering, (1990) pp 858-859, Kroschwitz, J. I., ed. John Wiley & Sons; Englisch et al., Angewandte Chemie, Int. Ed., 30:613 (1991); and Sanghvi, Y. S., (1993) Antisense Research and Applications, pp 289-302, Crooke, S. T. and Lebleu, B., ed., CRC Press. Certain of these nucleobases are particularly useful for increasing the binding affinity of the polynucleotide probes of the invention. These include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6 and O-6 substituted purines, including 2-aminopropyladenine, 5-propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to increase nucleic acid duplex stability by 0.6-1.2.degree. C. [Sanghvi, Y. S., (1993) Antisense Research and Applications, pp 276-278, Crooke, S. T. and Lebleu, B., ed., CRC Press, Boca Raton].

[0103] One skilled in the art will recognize that it is not necessary for all positions in a given polynucleotide probe or primer to be uniformly modified. The present invention, therefore, contemplates the incorporation of more than one of the aforementioned modifications into a single polynucleotide probe or even at a single nucleoside within the probe or primer.

[0104] One skilled in the art will also appreciate that the nucleotide sequence of the entire length of the polynucleotide probe or primer does not need to be derived from the target sequence. Thus, for example, the polynucleotide probe may comprise nucleotide sequences at the 5' and/or 3' termini that are not derived from the target sequences. Nucleotide sequences which are not derived from the nucleotide sequence of the target sequence may provide additional functionality to the polynucleotide probe. For example, they may provide a restriction enzyme recognition sequence or a "tag" that facilitates detection, isolation, purification or immobilisation onto a solid support. Alternatively, the additional nucleotides may provide a self-complementary sequence that allows the primer/probe to adopt a hairpin configuration. Such configurations are necessary for certain probes, for example, molecular beacon and Scorpion probes, which can be used in solution hybridization techniques.

[0105] The polynucleotide probes or primers can incorporate moieties useful in detection, isolation, purification, or immobilisation, if desired. Such moieties are well-known in the art (see, for example, Ausubel et al., (1997 & updates) Current Protocols in Molecular Biology, Wiley & Sons, New York) and are chosen such that the ability of the probe to hybridize with its target sequence is not affected.

[0106] Examples of suitable moieties are detectable labels, such as radioisotopes, fluorophores, chemiluminophores, enzymes, colloidal particles, and fluorescent microparticles, as well as antigens, antibodies, haptens, avidin/streptavidin, biotin, haptens, enzyme cofactors/substrates, enzymes, and the like.

[0107] A label can optionally be attached to or incorporated into a probe or primer polynucleotide to allow detection and/or quantitation of a target polynucleotide representing the target sequence of interest. The target polynucleotide may be the expressed target sequence RNA itself, a cDNA copy thereof, or an amplification product derived therefrom, and may be the positive or negative strand, so long as it can be specifically detected in the assay being used. Similarly, an antibody may be labeled.

[0108] In certain multiplex formats, labels used for detecting different targets may be distinguishable. The label can be attached directly (e.g., via covalent linkage) or indirectly, e.g., via a bridging molecule or series of molecules (e.g., a molecule or complex that can bind to an assay component, or via members of a binding pair that can be incorporated into assay components, e.g. biotin-avidin or streptavidin). Many labels are commercially available in activated forms which can readily be used for such conjugation (for example through amine acylation), or labels may be attached through known or determinable conjugation schemes, many of which are known in the art.

[0109] Labels useful in the invention described herein include any substance which can be detected when bound to or incorporated into the biomolecule of interest. Any effective detection method can be used, including optical, spectroscopic, electrical, piezoelectrical, magnetic, Raman scattering, surface plasmon resonance, colorimetric, calorimetric, etc. A label is typically selected from a chromophore, a lumiphore, a fluorophore, one member of a quenching system, a chromogen, a hapten, an antigen, a magnetic particle, a material exhibiting nonlinear optics, a semiconductor nanocrystal, a metal nanoparticle, an enzyme, an antibody or binding portion or equivalent thereof, an aptamer, and one member of a binding pair, and combinations thereof. Quenching schemes may be used, wherein a quencher and a fluorophore as members of a quenching pair may be used on a probe, such that a change in optical parameters occurs upon binding to the target introduce or quench the signal from the fluorophore. One example of such a system is a molecular beacon. Suitable quencher/fluorophore systems are known in the art. The label may be bound through a variety of intermediate linkages. For example, a polynucleotide may comprise a biotin-binding species, and an optically detectable label may be conjugated to biotin and then bound to the labeled polynucleotide. Similarly, a polynucleotide sensor may comprise an immunological species such as an antibody or fragment, and a secondary antibody containing an optically detectable label may be added.

[0110] Chromophores useful in the methods described herein include any substance which can absorb energy and emit light. For multiplexed assays, a plurality of different signaling chromophores can be used with detectably different emission spectra. The chromophore can be a lumophore or a fluorophore. Typical fluorophores include fluorescent dyes, semiconductor nanocrystals, lanthanide chelates, polynucleotide-specific dyes and green fluorescent protein.

[0111] Coding schemes may optionally be used, comprising encoded particles and/or encoded tags associated with different polynucleotides of the invention. A variety of different coding schemes are known in the art, including fluorophores, including SCNCs, deposited metals, and RF tags.

[0112] Polynucleotides from the described target sequences may be employed as probes for detecting target sequences expression, for ligation amplification schemes, or may be used as primers for amplification schemes of all or a portion of a target sequences. When amplified, either strand produced by amplification may be provided in purified and/or isolated form.

[0113] In one embodiment, polynucleotides of the invention include a nucleic acid depicted in (a) any one of SEQ ID NOs: 1-2114, or a subgroup thereof as set forth herein; (b) an RNA form of any one of the nucleic acids depicted in SEQ ID NOs: 1-2114, or a subgroup thereof as set forth herein; (c) a peptide nucleic acid form of any of the nucleic acids depicted in SEQ ID NOs: 1-2114, or a subgroup thereof as set forth herein; (d) a nucleic acid comprising at least 20 consecutive bases of any of (a-c); (e) a nucleic acid comprising at least 25 bases having at least 90% sequenced identity to any of (a-c); and (f) a complement to any of (a-e).

[0114] Complements may take any polymeric form capable of base pairing to the species recited in (a)-(e), including nucleic acid such as RNA or DNA, or may be a neutral polymer such as a peptide nucleic acid. Polynucleotides of the invention can be selected from the subsets of the recited nucleic acids described herein, as well as their complements.

[0115] In some embodiments, polynucleotides of the invention comprise at least 20 consecutive bases as depicted in SEQ ID NOs:1-2114, or a complement thereto. The polynucleotides may comprise at least 21, 22, 23, 24, 25, 27, 30, 32, 35 or more consecutive bases as depicted in SEQ ID NOs:1-2114, as applicable.

[0116] In some embodiments, the nucleic acid in (a) can be selected from those in Table 3, and from SEQ ID NOs:1, 4, 915, 6, 916, 9, 917, 920, 922, 14, 15, 16, 928, 929, 18, 19, 931, 20, 21, 935, and 936; or from SEQ ID NOs:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 914, 915, 916, 917, 918, 919, and 920; or from SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935 and 936; or from SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022; or from SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402 and 1425.

[0117] The polynucleotides may be provided in a variety of formats, including as solids, in solution, or in an array. The polynucleotides may optionally comprise one or more labels, which may be chemically and/or enzymatically incorporated into the polynucleotide.

[0118] In one embodiment, solutions comprising polynucleotide and a solvent are also provided. In some embodiments, the solvent may be water or may be predominantly aqueous. In some embodiments, the solution may comprise at least two, three, four, five, six, seven, eight, nine, ten, twelve, fifteen, seventeen, twenty or more different polynucleotides, including primers and primer pairs, of the invention. Additional substances may be included in the solution, alone or in combination, including one or more labels, additional solvents, buffers, biomolecules, polynucleotides, and one or more enzymes useful for performing methods described herein, including polymerases and ligases. The solution may further comprise a primer or primer pair capable of amplifying a polynucleotide of the invention present in the solution.

[0119] In some embodiments, one or more polynucleotides provided herein can be provided on a substrate. The substrate can comprise a wide range of material, either biological, nonbiological, organic, inorganic, or a combination of any of these. For example, the substrate may be a polymerized Langmuir Blodgett film, functionalized glass, Si, Ge, GaAs, GaP, SiO.sub.2, SiN.sub.4, modified silicon, or any one of a wide variety of gels or polymers such as (poly)tetrafluoroethylene, (poly)vinylidenedifluoride, polystyrene, cross-linked polystyrene, polyacrylic, polylactic acid, polyglycolic acid, poly(lactide coglycolide), polyanhydrides, poly(methyl methacrylate), poly(ethylene-co-vinyl acetate), polysiloxanes, polymeric silica, latexes, dextran polymers, epoxies, polycarbonates, or combinations thereof. Conducting polymers and photoconductive materials can be used.

[0120] Substrates can be planar crystalline substrates such as silica based substrates (e.g. glass, quartz, or the like), or crystalline substrates used in, e.g., the semiconductor and microprocessor industries, such as silicon, gallium arsenide, indium doped GaN and the like, and includes semiconductor nanocrystals.

[0121] The substrate can take the form of an array, a photodiode, an optoelectronic sensor such as an optoelectronic semiconductor chip or optoelectronic thin-film semiconductor, or a biochip. The location(s) of probe(s) on the substrate can be addressable; this can be done in highly dense formats, and the location(s) can be microaddressable or nanoaddressable.

[0122] Silica aerogels can also be used as substrates, and can be prepared by methods known in the art. Aerogel substrates may be used as free standing substrates or as a surface coating for another substrate material.

[0123] The substrate can take any form and typically is a plate, slide, bead, pellet, disk, particle, microparticle, nanoparticle, strand, precipitate, optionally porous gel, sheets, tube, sphere, container, capillary, pad, slice, film, chip, multiwell plate or dish, optical fiber, etc. The substrate can be any form that is rigid or semi-rigid. The substrate may contain raised or depressed regions on which an assay component is located. The surface of the substrate can be etched using known techniques to provide for desired surface features, for example trenches, v-grooves, mesa structures, or the like.

[0124] Surfaces on the substrate can be composed of the same material as the substrate or can be made from a different material, and can be coupled to the substrate by chemical or physical means. Such coupled surfaces may be composed of any of a wide variety of materials, for example, polymers, plastics, resins, polysaccharides, silica or silica-based materials, carbon, metals, inorganic glasses, membranes, or any of the above-listed substrate materials. The surface can be optically transparent and can have surface Si--OH functionalities, such as those found on silica surfaces.

[0125] The substrate and/or its optional surface can be chosen to provide appropriate characteristics for the synthetic and/or detection methods used. The substrate and/or surface can be transparent to allow the exposure of the substrate by light applied from multiple directions. The substrate and/or surface may be provided with reflective "mirror" structures to increase the recovery of light.

[0126] The substrate and/or its surface is generally resistant to, or is treated to resist, the conditions to which it is to be exposed in use, and can be optionally treated to remove any resistant material after exposure to such conditions.

[0127] The substrate or a region thereof may be encoded so that the identity of the sensor located in the substrate or region being queried may be determined Any suitable coding scheme can be used, for example optical codes, RFID tags, magnetic codes, physical codes, fluorescent codes, and combinations of codes.

Preparation of Probes and Primers

[0128] The polynucleotide probes or primers of the present invention can be prepared by conventional techniques well-known to those skilled in the art. For example, the polynucleotide probes can be prepared using solid-phase synthesis using commercially available equipment. As is well-known in the art, modified oligonucleotides can also be readily prepared by similar methods. The polynucleotide probes can also be synthesized directly on a solid support according to methods standard in the art. This method of synthesizing polynucleotides is particularly useful when the polynucleotide probes are part of a nucleic acid array.

[0129] Polynucleotide probes or primers can be fabricated on or attached to the substrate by any suitable method, for example the methods described in U.S. Pat. No. 5,143,854, PCT Publ. No. WO 92/10092, U.S. patent application Ser. No. 07/624,120, filed Dec. 6, 1990 (now abandoned), Fodor et al., Science, 251: 767-777 (1991), and PCT Publ. No. WO 90/15070). Techniques for the synthesis of these arrays using mechanical synthesis strategies are described in, e.g., PCT Publication No. WO 93/09668 and U.S. Pat. No. 5,384,261. Still further techniques include bead based techniques such as those described in PCT Appl. No. PCT/US93/04145 and pin based methods such as those described in U.S. Pat. No. 5,288,514. Additional flow channel or spotting methods applicable to attachment of sensor polynucleotides to a substrate are described in U.S. patent application Ser. No. 07/980,523, filed Nov. 20, 1992, and U.S. Pat. No. 5,384,261.

[0130] Alternatively, the polynucleotide probes of the present invention can be prepared by enzymatic digestion of the naturally occurring target gene, or mRNA or cDNA derived therefrom, by methods known in the art.

Prostate Cancer Prognostic Methods

[0131] The present invention further provides methods for characterizing prostate cancer sample for recurrence risk. The methods use the Prostate Cancer Prognostic Sets, probes and primers described herein to provide expression signatures or profiles from a test sample derived from a subject having or suspected of having prostate cancer. In some embodiments, such methods involve contacting a test sample with Prostate Cancer Prognostic probes (either in solution or immobilized) under conditions that permit hybridization of the probe(s) to any target nucleic acid(s) present in the test sample and then detecting any probe:target duplexes formed as an indication of the presence of the target nucleic acid in the sample. Expression patterns thus determined are then compared to one or more reference profiles or signatures. Optionally, the expression pattern can be normalized. The methods use the Prostate Cancer Prognostic Sets, probes and primers described herein to provide expression signatures or profiles from a test sample derived from a subject to classify the prostate cancer as recurrent or non-recurrent.

[0132] In some embodiments, such methods involve the specific amplification of target sequences nucleic acid(s) present in the test sample using methods known in the art to generate an expression profile or signature which is then compared to a reference profile or signature.

[0133] In some embodiments, the invention further provides for prognosing patient outcome, predicting likelihood of recurrence after prostatectomy and/or for designating treatment modalities.

[0134] In one embodiment, the methods generate expression profiles or signatures detailing the expression of the 2114 target sequences having altered relative expression with different prostate cancer outcomes. In one embodiment, the methods generate expression profiles or signatures detailing the expression of the subsets of these target sequences having 526 or 18 target sequences as described in the examples.

[0135] In some embodiments, increased relative expression of one or more of SEQ IDs:1-913, decreased relative expression of one or more of SEQ ID NOs:914-2114 or a combination of any thereof is indicative of a non-recurrent form of prostate cancer and may be predictive a NED clinical outcome after surgery. In some embodiments, increased relative expression of SEQ IDs:914-2114, decreased relative expression of one or more of SEQ ID NOs:1-913 or a combination of any thereof is indicative of a recurrent form of prostate cancer and may be predictive of a SYS clinical outcome after surgery. Increased or decreased expression of target sequences represented in these sequence listings, or of the target sequences described in the examples, may be utilized in the methods of the invention.

[0136] In one embodiment, intermediate levels of expression of one or more target sequences depicted in Table 7 indicate a probability of future biochemical recurrence.

[0137] In some embodiments, the methods detect combinations of expression levels of sequences exhibiting positive and negative correlation with a disease status. In one embodiment, the methods detect a minimal expression signature.

[0138] Any method of detecting and/or quantitating the expression of the encoded target sequences can in principle be used in the invention. Such methods can include Northern blotting, array or microarray hybridization, by enzymatic cleavage of specific structures (e.g., an Invader.RTM. assay, Third Wave Technologies, e.g. as described in U.S. Pat. Nos. 5,846,717, 6,090,543; 6,001,567; 5,985,557; and 5,994,069) and amplification methods, e.g. RT-PCR, including in a TaqMan.RTM. assay (PE Biosystems, Foster City, Calif., e.g. as described in U.S. Pat. Nos. 5,962,233 and 5,538,848), and may be quantitative or semi-quantitative, and may vary depending on the origin, amount and condition of the available biological sample. Combinations of these methods may also be used. For example, nucleic acids may be amplified, labeled and subjected to microarray analysis. Single-molecule sequencing (e.g., Illumina, Helicos, PacBio, ABI SOLID), in situ hybridization, bead-array technologies (e.g., Luminex xMAP, Illumina BeadChips), branched DNA technology (e.g., Panomics, Genisphere).

[0139] The expressed target sequences can be directly detected and/or quantitated, or may be copied and/or amplified to allow detection of amplified copies of the expressed target sequences or its complement. In some embodiments, degraded and/or fragmented RNA can be usefully analyzed for expression levels of target sequences, for example RNA having an RNA integrity number of less than 8.

[0140] In some embodiments, quantitative RT-PCR assays are used to measure the expression level of target sequences depicted in SEQ IDs: 1-2114. In other embodiments, a GeneChip or microarray can be used to measure the expression of one or more of the target sequences.

[0141] Molecular assays measure the relative expression levels of the target sequences, which can be normalized to the expression levels of one or more control sequences, for example array control sequences and/or one or more housekeeping genes, for example GAPDH. Increased (or decreased) relative expression of the target sequences as described herein, including any of SEQ ID NOs:1-2114, may thus be used alone or in any combination with each other in the methods described herein. In addition, negative control probes may be included.

Diagnostic Samples

[0142] Diagnostic samples for use with the systems and in the methods of the present invention comprise nucleic acids suitable for providing RNAs expression information. In principle, the biological sample from which the expressed RNA is obtained and analyzed for target sequence expression can be any material suspected of comprising prostate cancer tissue or cells. The diagnostic sample can be a biological sample used directly in a method of the invention. Alternatively, the diagnostic sample can be a sample prepared from a biological sample.

[0143] In one embodiments, the sample or portion of the sample comprising or suspected of comprising prostate cancer tissue or cells can be any source of biological material, including cells, tissue or fluid, including bodily fluids. Non-limiting examples of the source of the sample include an aspirate, a needle biopsy, a cytology pellet, a bulk tissue preparation or a section thereof obtained for example by surgery or autopsy, lymph fluid, blood, plasma, serum, tumors, and organs.

[0144] The samples may be archival samples, having a known and documented medical outcome, or may be samples from current patients whose ultimate medical outcome is not yet known.

[0145] In some embodiments, the sample may be dissected prior to molecular analysis. The sample may be prepared via macrodissection of a bulk tumor specimen or portion thereof, or may be treated via microdissection, for example via Laser Capture Microdissection (LCM).

[0146] The sample may initially be provided in a variety of states, as fresh tissue, fresh frozen tissue, fine needle aspirates, and may be fixed or unfixed. Frequently, medical laboratories routinely prepare medical samples in a fixed state, which facilitates tissue storage. A variety of fixatives can be used to fix tissue to stabilize the morphology of cells, and may be used alone or in combination with other agents. Exemplary fixatives include crosslinking agents, alcohols, acetone, Bouin's solution, Zenker solution, Hely solution, osmic acid solution and Carnoy solution.

[0147] Crosslinking fixatives can comprise any agent suitable for forming two or more covalent bonds, for example an aldehyde. Sources of aldehydes typically used for fixation include formaldehyde, paraformaldehyde, glutaraldehyde or formalin. Preferably, the crosslinking agent comprises formaldehyde, which may be included in its native form or in the form of paraformaldehyde or formalin. One of skill in the art would appreciate that for samples in which crosslinking fixatives have been used special preparatory steps may be necessary including for example heating steps and proteinase-k digestion; see methods

[0148] One or more alcohols may be used to fix tissue, alone or in combination with other fixatives. Exemplary alcohols used for fixation include methanol, ethanol and isopropanol.

[0149] Formalin fixation is frequently used in medical laboratories. Formalin comprises both an alcohol, typically methanol, and formaldehyde, both of which can act to fix a biological sample.

[0150] Whether fixed or unfixed, the biological sample may optionally be embedded in an embedding medium. Exemplary embedding media used in histology including paraffin, Tissue-Tek.RTM. V.I.P..TM., Paramat, Paramat Extra, Paraplast, Paraplast X-tra, Paraplast Plus, Peel Away Paraffin Embedding Wax, Polyester Wax, Carbowax Polyethylene Glycol, Polyfin.TM., Tissue Freezing Medium TFM.TM., Cryo-Gel.TM., and OCT Compound (Electron Microscopy Sciences, Hatfield, Pa.). Prior to molecular analysis, the embedding material may be removed via any suitable techniques, as known in the art. For example, where the sample is embedded in wax, the embedding material may be removed by extraction with organic solvent(s), for example xylenes. Kits are commercially available for removing embedding media from tissues. Samples or sections thereof may be subjected to further processing steps as needed, for example serial hydration or dehydration steps.

[0151] In some embodiments, the sample is a fixed, wax-embedded biological sample. Frequently, samples from medical laboratories are provided as fixed, wax-embedded samples, most commonly as formalin-fixed, paraffin embedded (FFPE) tissues.

[0152] Whatever the source of the biological sample, the target polynucleotide that is ultimately assayed can be prepared synthetically (in the case of control sequences), but typically is purified from the biological source and subjected to one or more preparative steps. The RNA may be purified to remove or diminish one or more undesired components from the biological sample or to concentrate it. Conversely, where the RNA is too concentrated for the particular assay, it may be diluted.

RNA Extraction

[0153] RNA can be extracted and purified from biological samples using any suitable technique. A number of techniques are known in the art, and several are commercially available (e.g., FormaPure.TM. nucleic acid extraction kit, Agencourt Biosciences, Beverly Mass., High Pure FFPE RNA Micro Kit.TM., Roche Applied Science, Indianapolis, Ind.). RNA can be extracted from frozen tissue sections using TRIzol (Invitrogen, Carlsbad, Calif.) and purified using RNeasy Protect kit (Qiagen, Valencia, Calif.). RNA can be further purified using DNAse I treatment (Ambion, Austin, Tex.) to eliminate any contaminating DNA. RNA concentrations can be made using a Nanodrop ND-1000 spectrophotometer (Nanodrop Technologies, Rockland, Del.). RNA integrity can be evaluated by running electropherograms, and RNA integrity number (RIN, a correlative measure that indicates intactness of mRNA) can be determined using the RNA 6000 PicoAssay for the Bioanalyzer 2100 (Agilent Technologies, Santa Clara, Calif.).

Reverse Transcription for QRT-PCR Analysis

[0154] Reverse transcription can be performed using the Omniscript kit (Qiagen, Valencia, Calif.), Superscript III kit (Invitrogen, Carlsbad, Calif.), for RT-PCR. Target-specific priming can be performed in order to increase the sensitivity of detection of target sequences and generate target-specific cDNA.

[0155] TaqMan.RTM. Gene Expression Analysis

[0156] TaqMan.RTM. RT-PCR can be performed using Applied Biosystems Prism (ABI) 7900 HT instruments in a 5 .mu.l volume with target sequence-specific cDNA equivalent to 1 ng total RNA. Primers and probes concentrations for TaqMan analysis are added to amplify fluorescent amplicons using PCR cycling conditions such as 95.degree. C. for 10 minutes for one cycle, 95.degree. C. for 20 seconds, and 60.degree. C. for 45 seconds for 40 cycles. A reference sample can be assayed to ensure reagent and process stability. Negative controls (i.e., no template) should be assayed to monitor any exogenous nucleic acid contamination.

Amplification and Hybridization

[0157] Following sample collection and nucleic acid extraction, the nucleic acid portion of the sample comprising RNA that is or can be used to prepare the target polynucleotide(s) of interest can be subjected to one or more preparative reactions. These preparative reactions can include in vitro transcription (IVT), labeling, fragmentation, amplification and other reactions. mRNA can first be treated with reverse transcriptase and a primer to create cDNA prior to detection, quantitation and/or amplification; this can be done in vitro with purified mRNA or in situ, e.g., in cells or tissues affixed to a slide.

[0158] By "amplification" is meant any process of producing at least one copy of a nucleic acid, in this case an expressed RNA, and in many cases produces multiple copies. An amplification product can be RNA or DNA, and may include a complementary strand to the expressed target sequence. DNA amplification products can be produced initially through reverse translation and then optionally from further amplification reactions. The amplification product may include all or a portion of a target sequence, and may optionally be labeled. A variety of amplification methods are suitable for use, including polymerase-based methods and ligation-based methods. Exemplary amplification techniques include the polymerase chain reaction method (PCR), the ligase chain reaction (LCR), ribozyme-based methods, self sustained sequence replication (3SR), nucleic acid sequence-based amplification (NASBA), the use of Q Beta replicase, reverse transcription, nick translation, and the like.

[0159] Asymmetric amplification reactions may be used to preferentially amplify one strand representing the target sequence that is used for detection as the target polynucleotide. In some cases, the presence and/or amount of the amplification product itself may be used to determine the expression level of a given target sequence. In other instances, the amplification product may be used to hybridize to an array or other substrate comprising sensor polynucleotides which are used to detect and/or quantitate target sequence expression.

[0160] The first cycle of amplification in polymerase-based methods typically forms a primer extension product complementary to the template strand. If the template is single-stranded RNA, a polymerase with reverse transcriptase activity is used in the first amplification to reverse transcribe the RNA to DNA, and additional amplification cycles can be performed to copy the primer extension products. The primers for a PCR must, of course, be designed to hybridize to regions in their corresponding template that will produce an amplifiable segment; thus, each primer must hybridize so that its 3' nucleotide is paired to a nucleotide in its complementary template strand that is located 3' from the 3' nucleotide of the primer used to replicate that complementary template strand in the PCR.

[0161] The target polynucleotide can be amplified by contacting one or more strands of the target polynucleotide with a primer and a polymerase having suitable activity to extend the primer and copy the target polynucleotide to produce a full-length complementary polynucleotide or a smaller portion thereof. Any enzyme having a polymerase activity that can copy the target polynucleotide can be used, including DNA polymerases, RNA polymerases, reverse transcriptases, enzymes having more than one type of polymerase or enzyme activity. The enzyme can be thermolabile or thermostable. Mixtures of enzymes can also be used. Exemplary enzymes include: DNA polymerases such as DNA Polymerase I ("Pol I"), the Klenow fragment of Pol I, T4, T7, Sequenase.RTM. T7, Sequenase.RTM. Version 2.0 T7, Tub, Taq, Tth, Pfx, Pfu, Tsp, Tfl, Tli and Pyrococcus sp GB-D DNA polymerases; RNA polymerases such as E. coli, SP6, T3 and T7 RNA polymerases; and reverse transcriptases such as AMV, M-MuLV, MMLV, RNAse H.sup.- MMLV (SuperScript.RTM.), SuperScript.RTM. II, ThermoScript.RTM., HIV-1, and RAV2 reverse transcriptases. All of these enzymes are commercially available. Exemplary polymerases with multiple specificities include RAV2 and Tli (exo-) polymerases. Exemplary thermostable polymerases include Tub, Taq, Tth, Pfx, Pfu, Tsp, Tfl, Tli and Pyrococcus sp. GB-D DNA polymerases.

[0162] Suitable reaction conditions are chosen to permit amplification of the target polynucleotide, including pH, buffer, ionic strength, presence and concentration of one or more salts, presence and concentration of reactants and cofactors such as nucleotides and magnesium and/or other metal ions (e.g., manganese), optional cosolvents, temperature, thermal cycling profile for amplification schemes comprising a polymerase chain reaction, and may depend in part on the polymerase being used as well as the nature of the sample. Cosolvents include formamide (typically at from about 2 to about 10%), glycerol (typically at from about 5 to about 10%), and DMSO (typically at from about 0.9 to about 10%). Techniques may be used in the amplification scheme in order to minimize the production of false positives or artifacts produced during amplification. These include "touchdown" PCR, hot-start techniques, use of nested primers, or designing PCR primers so that they form stem-loop structures in the event of primer-dimer formation and thus are not amplified. Techniques to accelerate PCR can be used, for example centrifugal PCR, which allows for greater convection within the sample, and comprising infrared heating steps for rapid heating and cooling of the sample. One or more cycles of amplification can be performed. An excess of one primer can be used to produce an excess of one primer extension product during PCR; preferably, the primer extension product produced in excess is the amplification product to be detected. A plurality of different primers may be used to amplify different target polynucleotides or different regions of a particular target polynucleotide within the sample.

[0163] An amplification reaction can be performed under conditions which allow an optionally labeled sensor polynucleotide to hybridize to the amplification product during at least part of an amplification cycle. When the assay is performed in this manner, real-time detection of this hybridization event can take place by monitoring for light emission or fluorescence during amplification, as known in the art.

[0164] Where the amplification product is to be used for hybridization to an array or microarray, a number of suitable commercially available amplification products are available. These include amplification kits available from NuGEN, Inc. (San Carlos, Calif.), including the WT-Ovation.TM. System, WT-Ovation.TM. System v2, WT-Ovation.TM. Pico System, WT-Ovation.TM. FFPE Exon Module, WT-Ovation.TM. FFPE Exon Module RiboAmp and RiboAmp.sup.Plus RNA Amplification Kits (MDS Analytical Technologies (formerly Arcturus) (Mountain View, Calif.), Genisphere, Inc. (Hatfield, Pa.), including the RampUp Plus.TM. and SenseAmp.TM. RNA Amplification kits, alone or in combination. Amplified nucleic acids may be subjected to one or more purification reactions after amplification and labeling, for example using magnetic beads (e.g., RNAClean magnetic beads, Agencourt Biosciences).

[0165] Multiple RNA biomarkers can be analyzed using real-time quantitative multiplex RT-PCR platforms and other multiplexing technologies such as GenomeLab GeXP Genetic Analysis System (Beckman Coulter, Foster City, Calif.), SmartCycler.RTM. 9600 or GeneXpert(R) Systems (Cepheid, Sunnyvale, Calif.), ABI 7900 HT Fast Real Time PCR system (Applied Biosystems, Foster City, Calif.), LightCycler.RTM. 480 System (Roche Molecular Systems, Pleasanton, Calif.), xMAP 100 System (Luminex, Austin, Tex.) Solexa Genome Analysis System (Illumina, Hayward, Calif.), OpenArray Real Time qPCR (BioTrove, Woburn, Mass.) and BeadXpress System (Illumina, Hayward, Calif.).

Prostate Classification Arrays

[0166] The present invention contemplates that a Prostate Cancer Prognostic Set or probes derived therefrom may be provided in an array format. In the context of the present invention, an "array" is a spatially or logically organized collection of polynucleotide probes. Any array comprising sensor probes specific for two or more of SEQ ID NOs: 1-2114 or a product derived therefrom can be used. Desirably, an array will be specific for 5, 10, 15, 20, 25, 30, 50, 75, 100, 150, 200, 250, 300, 350, 400, 450, 500, 600, 700, 1000, 1200, 1400, 1600, 1800, 2000 or more of SEQ ID NOs: 1-2114. Expression of these sequences may be detected alone or in combination with other transcripts. In some embodiments, an array is used which comprises a wide range of sensor probes for prostate-specific expression products, along with appropriate control sequences. An array of interest is the Human Exon 1.0 ST Array (HuEx 1.0 ST, Affymetrix, Inc., Santa Clara, Calif.).

[0167] Typically the polynucleotide probes are attached to a solid substrate and are ordered so that the location (on the substrate) and the identity of each are known. The polynucleotide probes can be attached to one of a variety of solid substrates capable of withstanding the reagents and conditions necessary for use of the array. Examples include, but are not limited to, polymers, such as (poly)tetrafluoroethylene, (poly)vinylidenedifluoride, polystyrene, polycarbonate, polypropylene and polystyrene; ceramic; silicon; silicon dioxide; modified silicon; (fused) silica, quartz or glass; functionalized glass; paper, such as filter paper; diazotized cellulose; nitrocellulose filter; nylon membrane; and polyacrylamide gel pad. Substrates that are transparent to light are useful for arrays that will be used in an assay that involves optical detection.

[0168] Examples of array formats include membrane or filter arrays (for example, nitrocellulose, nylon arrays), plate arrays (for example, multiwell, such as a 24-, 96-, 256-, 384-, 864- or 1536-well, microtitre plate arrays), pin arrays, and bead arrays (for example, in a liquid "slurry"). Arrays on substrates such as glass or ceramic slides are often referred to as chip arrays or "chips." Such arrays are well known in the art. In one embodiment of the present invention, the Prostate Cancer Prognosticarray is a chip.

Data Analysis

[0169] Array data can be managed and analyzed using techniques known in the art. The Genetrix suite of tools can be used for microarray analysis (Epicenter Software, Pasadena, Calif.). Probe set modeling and data pre-processing can be derived using the Robust Multi-Array (RMA) algorithm or variant GC-RMA, Probe Logarithmic Intensity Error (PLIER) algorithm or variant iterPLIER. Variance or intensity filters can be applied to pre-process data using the RMA algorithm, for example by removing target sequences with a standard deviation of <10 or a mean intensity of <100 intensity units of a normalized data range, respectively.

[0170] In some embodiments, one or more pattern recognition methods can be used in analyzing the expression level of target sequences. The pattern recognition method can comprise a linear combination of expression levels, or a nonlinear combination of expression levels. In some embodiments, expression measurements for RNA transcripts or combinations of RNA transcript levels are formulated into linear or non-linear models or algorithms (i.e., an `expression signature`) and converted into a likelihood score. This likelihood score indicates the probability that a biological sample is from a patient who will exhibit no evidence of disease, who will exhibit systemic cancer, or who will exhibit biochemical recurrence. The likelihood score can be used to distinguish these disease states. The models and/or algorithms can be provided in machine readable format, and may be used to correlate expression levels or an expression profile with a disease state, and/or to designate a treatment modality for a patient or class of patients.

[0171] Thus, results of the expression level analysis can be used to correlate increased expression of RNAs corresponding to SEQ ID NOs: 1-2114, or subgroups thereof as described herein, with prostate cancer outcome, and to designate a treatment modality.

[0172] Factors known in the art for diagnosing and/or suggesting, selecting, designating, recommending or otherwise determining a course of treatment for a patient or class of patients suspected of having prostate cancer can be employed in combination with measurements of the target sequence expression. These techniques include cytology, histology, ultrasound analysis, MRI results, CT scan results, and measurements of PSA levels.

[0173] Certified tests for classifying prostate disease status and/or designating treatment modalities are also provided. A certified test comprises a means for characterizing the expression levels of one or more of the target sequences of interest, and a certification from a government regulatory agency endorsing use of the test for classifying the prostate disease status of a biological sample.

[0174] In some embodiments, the certified test may comprise reagents for amplification reactions used to detect and/or quantitate expression of the target sequences to be characterized in the test. An array of probe nucleic acids can be used, with or without prior target amplification, for use in measuring target sequence expression.

[0175] The test is submitted to an agency having authority to certify the test for use in distinguishing prostate disease status and/or outcome. Results of detection of expression levels of the target sequences used in the test and correlation with disease status and/or outcome are submitted to the agency. A certification authorizing the diagnostic and/or prognostic use of the test is obtained.

[0176] Also provided are portfolios of expression levels comprising a plurality of normalized expression levels of the target sequences described herein, including SEQ ID NOs:1-2114. Such portfolios may be provided by performing the methods described herein to obtain expression levels from an individual patient or from a group of patients. The expression levels can be normalized by any method known in the art; exemplary normalization methods that can be used in various embodiments include Robust Multichip Average (RMA), probe logarithmic intensity error estimation (PLIER), non-linear fit (NLFIT) quantile-based and nonlinear normalization, and combinations thereof. Background correction can also be performed on the expression data; exemplary techniques useful for background correction include mode of intensities, normalized using median polish probe modeling and sketch-normalization.

[0177] In some embodiments, portfolios are established such that the combination of genes in the portfolio exhibit improved sensitivity and specificity relative to known methods. In considering a group of genes for inclusion in a portfolio, a small standard deviation in expression measurements correlates with greater specificity. Other measurements of variation such as correlation coefficients can also be used in this capacity. The invention also encompasses the above methods where the specificity is at least about 50% or at least about 60%. The invention also encompasses the above methods where the sensitivity is at least about 90%.

[0178] The gene expression profiles of each of the target sequences comprising the portfolio can fixed in a medium such as a computer readable medium. This can take a number of forms. For example, a table can be established into which the range of signals (e.g., intensity measurements) indicative of disease or outcome is input. Actual patient data can then be compared to the values in the table to determine the patient samples diagnosis or prognosis. In a more sophisticated embodiment, patterns of the expression signals (e.g., fluorescent intensity) are recorded digitally or graphically.

[0179] The expression profiles of the samples can be compared to a control portfolio. If the sample expression patterns are consistent with the expression pattern for a known disease or disease outcome, the expression patterns can be used to designate one or more treatment modalities. For patients with test scores consistent with systemic disease outcome after prostatectomy, additional treatment modalities such as adjuvant chemotherapy (e.g., docetaxel, mitoxantrone and prednisone), systemic radiation therapy (e.g., samarium or strontium) and/or anti-androgen therapy (e.g., surgical castration, finasteride, dutasteride) can be designated. Such patients would likely be treated immediately with anti-androgen therapy alone or in combination with radiation therapy in order to eliminate presumed micro-metastatic disease, which cannot be detected clinically but can be revealed by the target sequence expression signature. Such patients can also be more closely monitored for signs of disease progression. For patients with test scores consistent with PSA or NED, adjuvant therapy would not likely be recommended by their physicians in order to avoid treatment-related side effects such as metabolic syndrome (e.g., hypertension, diabetes and/or weight gain) or osteoporosis. Patients with samples consistent with NED could be designated for watchful waiting, or for no treatment. Patients with test scores that do not correlate with systemic disease but who have successive PSA increases could be designated for watchful waiting, increased monitoring, or lower dose or shorter duration anti-androgen therapy.

[0180] Target sequences can be grouped so that information obtained about the set of target sequences in the group can be used to make or assist in making a clinically relevant judgment such as a diagnosis, prognosis, or treatment choice.

[0181] A patient report is also provided comprising a representation of measured expression levels of a plurality of target sequences in a biological sample from the patient, wherein the representation comprises expression levels of target sequences corresponding to any one, two, three, four, five, six, eight, ten, twenty, thirty, fifty or more of the target sequences depicted in SEQ ID NOs: 1-2114, or of the subsets described herein, or of a combination thereof. In some embodiments, the representation of the measured expression level(s) may take the form of a linear or nonlinear combination of expression levels of the target sequences of interest. The patient report may be provided in a machine (e.g., a computer) readable format and/or in a hard (paper) copy. The report can also include standard measurements of expression levels of said plurality of target sequences from one or more sets of patients with known disease status and/or outcome. The report can be used to inform the patient and/or treating physician of the expression levels of the expressed target sequences, the likely medical diagnosis and/or implications, and optionally may recommend a treatment modality for the patient.

[0182] Also provided are representations of the gene expression profiles useful for treating, diagnosing, prognosticating, and otherwise assessing disease. In some embodiments, these profile representations are reduced to a medium that can be automatically read by a machine such as computer readable media (magnetic, optical, and the like). The articles can also include instructions for assessing the gene expression profiles in such media. For example, the articles may comprise a readable storage form having computer instructions for comparing gene expression profiles of the portfolios of genes described above. The articles may also have gene expression profiles digitally recorded therein so that they may be compared with gene expression data from patient samples. Alternatively, the profiles can be recorded in different representational format. A graphical recordation is one such format. Clustering algorithms can assist in the visualization of such data.

Kits

[0183] Kits for performing the desired method(s) are also provided, and comprise a container or housing for holding the components of the kit, one or more vessels containing one or more nucleic acid(s), and optionally one or more vessels containing one or more reagents. The reagents include those described in the composition of matter section above, and those reagents useful for performing the methods described, including amplification reagents, and may include one or more probes, primers or primer pairs, enzymes (including polymerases and ligases), intercalating dyes, labeled probes, and labels that can be incorporated into amplification products.

[0184] In some embodiments, the kit comprises primers or primer pairs specific for those subsets and combinations of target sequences described herein. At least two, three, four or five primers or pairs of primers suitable for selectively amplifying the same number of target sequence-specific polynucleotides can be provided in kit form. In some embodiments, the kit comprises from five to fifty primers or pairs of primers suitable for amplifying the same number of target sequence-representative polynucleotides of interest.

[0185] The primers or primer pairs of the kit, when used in an amplification reaction, specifically amplify at least a portion of a nucleic acid depicted in one of SEQ ID NOs: 1-2114 (or subgroups thereof as set forth herein), an RNA form thereof, or a complement to either thereof. The kit may include a plurality of such primers or primer pairs which can specifically amplify a corresponding plurality of different nucleic acids depicted in one of SEQ ID NOs: 1-2114 (or subgroups thereof as set forth herein), RNA forms thereof, or complements thereto. At least two, three, four or five primers or pairs of primers suitable for selectively amplifying the same number of target sequence-specific polynucleotides can be provided in kit form. In some embodiments, the kit comprises from five to fifty primers or pairs of primers suitable for amplifying the same number of target sequence-representative polynucleotides of interest.

[0186] The reagents may independently be in liquid or solid form. The reagents may be provided in mixtures. Control samples and/or nucleic acids may optionally be provided in the kit. Control samples may include tissue and/or nucleic acids obtained from or representative of prostate tumor samples from patients showing no evidence of disease, as well as tissue and/or nucleic acids obtained from or representative of prostate tumor samples from patients that develop systemic prostate cancer.

[0187] The nucleic acids may be provided in an array format, and thus an array or microarray may be included in the kit. The kit optionally may be certified by a government agency for use in prognosing the disease outcome of prostate cancer patients and/or for designating a treatment modality.

[0188] Instructions for using the kit to perform one or more methods of the invention can be provided with the container, and can be provided in any fixed medium. The instructions may be located inside or outside the container or housing, and/or may be printed on the interior or exterior of any surface thereof. A kit may be in multiplex form for concurrently detecting and/or quantitating one or more different target polynucleotides representing the expressed target sequences.

Devices

[0189] Devices useful for performing methods of the invention are also provided. The devices can comprise means for characterizing the expression level of a target sequence of the invention, for example components for performing one or more methods of nucleic acid extraction, amplification, and/or detection. Such components may include one or more of an amplification chamber (for example a thermal cycler), a plate reader, a spectrophotometer, capillary electrophoresis apparatus, a chip reader, and or robotic sample handling components. These components ultimately can obtain data that reflects the expression level of the target sequences used in the assay being employed.

[0190] The devices may include an excitation and/or a detection means. Any instrument that provides a wavelength that can excite a species of interest and is shorter than the emission wavelength(s) to be detected can be used for excitation. Commercially available devices can provide suitable excitation wavelengths as well as suitable detection components.

[0191] Exemplary excitation sources include a broadband UV light source such as a deuterium lamp with an appropriate filter, the output of a white light source such as a xenon lamp or a deuterium lamp after passing through a monochromator to extract out the desired wavelength(s), a continuous wave (cw) gas laser, a solid state diode laser, or any of the pulsed lasers. Emitted light can be detected through any suitable device or technique; many suitable approaches are known in the art. For example, a fluorimeter or spectrophotometer may be used to detect whether the test sample emits light of a wavelength characteristic of a label used in an assay.

[0192] The devices typically comprise a means for identifying a given sample, and of linking the results obtained to that sample. Such means can include manual labels, barcodes, and other indicators which can be linked to a sample vessel, and/or may optionally be included in the sample itself, for example where an encoded particle is added to the sample. The results may be linked to the sample, for example in a computer memory that contains a sample designation and a record of expression levels obtained from the sample. Linkage of the results to the sample can also include a linkage to a particular sample receptacle in the device, which is also linked to the sample identity.

[0193] The devices also comprise a means for correlating the expression levels of the target sequences being studied with a prognosis of disease outcome. Such means may comprise one or more of a variety of correlative techniques, including lookup tables, algorithms, multivariate models, and linear or nonlinear combinations of expression models or algorithms. The expression levels may be converted to one or more likelihood scores, reflecting a likelihood that the patient providing the sample will exhibit a particular disease outcome. The models and/or algorithms can be provided in machine readable format, and can optionally further designate a treatment modality for a patient or class of patients.

[0194] The device also comprises output means for outputting the disease status, prognosis and/or a treatment modality. Such output means can take any form which transmits the results to a patient and/or a healthcare provider, and may include a monitor, a printed format, or both. The device may use a computer system for performing one or more of the steps provided.

CITATIONS

Patents and Published Applications

[0195] 1. US 2003/0224399 A1 patent application Methods for determining the prognosis for patients with a prostate neoplastic condition 2003 Dec. 4 [0196] 2. US 2007/0048738 A1 patent application Methods and compositions for diagnosis, staging and prognosis of prostate cancer 2007 Mar. 1 [0197] 3. US 2007/0099197 A1 patent application Methods of prognosis of prostate cancer 2007 May 3 [0198] 4. US 2007/0259352 A1 patent application Prostate cancer-related nucleic acids 2007 Nov. 8 [0199] 5. US 2008/0009001 A1 patent application Method for Identification of Neoplastic Transformation with Particular Reference to Prostate Cancer 2008 Jan. 10

Publications

[0199] [0200] 1: Cooper C S, Campbell C, Jhavar S. Mechanisms of Disease: biomarkers and molecular targets from microarray gene expression studies in prostate cancer. Nat Clin Pract Urol. 2007 December; 4(12):677-87. Review. [0201] 2: Reddy G K, Balk S P. Clinical utility of microarray-derived genetic signatures in predicting outcomes in prostate cancer. Clin Genitourin Cancer. 2006 December; 5(3):187-9. Review. [0202] 3: Nelson P S. Predicting prostate cancer behavior using transcript profiles. J Urol. 2004 November; 172(5 Pt 2):S28-32; discussion S33. Review. [0203] 4: Bibikova M, Chudin E, Arsanjani A, Zhou L, Garcia E W, Modder J, Kostelec M, Barker D, Downs T, Fan J B, Wang-Rodriguez J. Expression signatures that correlated with Gleason score and relapse in prostate cancer. Genomics. 2007 June; 89(6):666-72. Epub 2007 Apr. 24. [0204] 5: Schlomm T, Erbersdobler A, Mirlacher M, Sauter G. Molecular staging of prostate cancer in the year 2007. World J Urol. 2007 March; 25(1):19-30. Epub 2007 Mar. 2. Review. [0205] 6: Mendiratta P, Febbo P G. Genomic signatures associated with the development, progression, and outcome of prostate cancer. Mol Diagn Ther. 2007; 11(6):345-54. [0206] 7: Reddy G K, Balk S P. Clinical utility of microarray-derived genetic signatures in predicting outcomes in prostate cancer. Clin Genitourin Cancer. 2006 December; 5(3):187-9. Review. [0207] 8: True L, Coleman I, Hawley S, Huang C Y, Gifford D, Coleman R, Beer T M, Gelmann E, Datta M, Mostaghel E, Knudsen B, Lange P, Vessella R, Lin D, Hood L, Nelson P S. A molecular correlate to the Gleason grading system for prostate adenocarcinoma. Proc Natl Acad Sci USA. 2006 Jul. 18; 103(29):10991-6. Epub 2006 Jul. 7. [0208] 9: Stephenson A J, Smith A, Kattan M W, Satagopan J, Reuter V E, Scardino P T, Gerald W L. Integration of gene expression profiling and clinical variables to predict prostate carcinoma recurrence after radical prostatectomy. Cancer. 2005 Jul. 15; 104(2):290-8. [0209] 10: Bueno R, Loughlin K R, Powell M H, Gordon G J. A diagnostic test for prostate cancer from gene expression profiling data. J Urol. 2004 February; 171(2 Pt 1):903-6. [0210] 11: Yu Y P, Landsittel D, Jing L, Nelson J, Ren B, Liu L, McDonald C, Thomas R, Dhir R, Finkelstein S, Michalopoulos G, Becich M, Luo J H. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol. 2004 Jul. 15; 22(14):2790-9. [0211] 12: Feroze-Merzoug F, Schober M S, Chen Y Q. Molecular profiling in prostate cancer. Cancer Metastasis Rev. 2001; 20(3-4):165-71. Review. [0212] 13: Nakagawa T, Kollmeyer T M, Morlan B W, Anderson S K, Bergstralh E J, Davis B J, Asmann Y W, Klee G G, Ballman K V, Jenkins R B. A tissue biomarker panel predicting systemic progression after PSA recurrence post-definitive prostate cancer therapy. PLoS ONE. 2008; 3(5):e2318. [0213] 14: Shariat S F, Karakiewicz P I, Roehrborn C G, Kattan M W. An updated catalog of prostate cancer predictive tools. Cancer 2008; 113(11): 3062-6.

EXAMPLES

[0214] To gain a better understanding of the invention described herein, the following examples are set forth. It will be understood that these examples are intended to describe illustrative embodiments of the invention and are not intended to limit the scope of the invention in any way. Efforts have been made to ensure accuracy with respect to numbers used (e.g., amounts, temperature, etc.) but some experimental error and deviation should be accounted for. Unless otherwise indicated, parts are parts by weight, temperature is degree centigrade and pressure is at or near atmospheric, and all materials are commercially available.

Example 1

Identification of Target Sequences Differentially Expressed in Prostate Disease States

[0215] Tissue Samples. Formalin-fixed paraffin embedded (FFPE) samples of human prostate adenocarcinoma prostatectomies were collected from patients at the Mayo Clinic Comprehensive Cancer Center according to an institutional review board-approved protocol and stored in the Department of Pathology for up to 20 years. For each patient sample four 4 micron sections were cut from formalin-fixed paraffin embedded blocks. Pathological review of FFPE tissue sections was used to guide macrodissection of tumor and surrounding normal tissue. Patients were classified into one of three clinical disease states; no evidence of disease (NED, n=10) for those patients with no biochemical or other clinical signs of disease progression (at least 10 years follow-up); prostate-specific antigen biochemical recurrence (PSA, n=10) for those patients with two successive increases in PSA measurements above an established cut-point of >4 ng/mL (`rising PSA`); and systemic disease (SYS, n=10) for those patients that had `rising PSA` and developed metastases or clinically detectable disease progression within five years after initial prostatectomy. Clinical disease was confirmed using bone or CT scans for prostate cancer metastases.

[0216] RNA Extraction. RNA was extracted and purified from FFPE tissue sections using a modified protocol for the commercially available High Pure FFPE RNA Micro nucleic acid extraction kit (Roche Applied Sciences, Indianapolis, Ind.). RNA concentrations were calculated using a Nanodrop ND-1000 spectrophotometer (Nanodrop Technologies, Rockland, Del.).

[0217] RNA Amplification and GeneChip Hybridization. Purified RNA was subjected to whole-transcriptome amplification using the WT-Ovation FFPE system including the WT-Ovation Exon and FL-Ovation Biotin V2 labeling modules, with the following modifications. Fifty (50) nanograms of RNA extracted from FFPE sections was used to generate amplified Ribo-SPIA product. For the WT-Ovation Exon sense-target strand conversion kit 4 ug of Ribo-SPIA product were used. All clean-up steps were performed with RNAClean magnetic beads (Agencourt Biosciences). Between 2.5 and 5 micrograms of WT-Ovation Exon product were used to fragment and label using the FL-Ovation Biotin V2 labeling module and labeled product was hybridized to Affymetrix Human Exon 1.0 ST GeneChips following manufacturer's recommendations (Affymetrix, Santa Clara, Calif.). Of the 30 samples processed, 22 had sufficient amplified material (i.e., >2.5 ug of WT-Ovation Exon product) for GeneChip hybridization.

[0218] Microarray Analysis. All data management and analysis was conducted using the Genetrix suite of tools for microarray analysis (Epicenter Software, Pasadena, Calif.). Probe set modeling and data pre-processing were derived using the Robust Multi-Array (RMA) algorithm. The mode of intensity values was used for background correction and RMA-sketch was used for normalization and probe modeling used a median polish routine. A variance filter was applied to data pre-processed using the RMA algorithm, by removing target sequences with a mean intensity of <10 intensity units of a normalized data range. Target sequences typically comprise four individual probes that interrogate the expression of RNA transcripts or portions thereof. Target sequence annotations and the sequences (RNAs) that they interrogate were downloaded from the Affymetrix website (www.netaffx.com). Supervised analysis of differentially expressed RNA transcripts was determined based on the fold change in the average expression (at least 2 fold change) and the associated t-test, with a p-value cut-off of p<0.001 between different prostate cancer patient disease states. Linear regression was also used to screen differentially expressed transcripts that displayed an expression pattern of NED>PSA>SYS or SYS>PSA>NED and genes were selected with a p-value cut-off of p<0.01 for two-way hierarchical clustering using Pearson's correlation distance metric with complete-linkage cluster distances.

[0219] Archived FFPE blocks of tumors were selected from 30 patients that had undergone a prostatectomy at the Mayo Clinic Comprehensive Cancer Center between the years 1987-1997, providing for at least 10 years follow-up on each patient. Twenty-two patient samples had RNA of sufficient quantity and quality for RNA amplification and subsequent GeneChip hybridization. Three clinical categories of patients were evaluated; patients alive with no evidence of disease (`NED`, n=6), patients with rising PSA or biochemical recurrence (defined as two successive increases in PSA measurements) (`PSA`, n=7) and patients with rising PSA and clinical evidence of systemic or recurrent disease (e.g., determined by bone scan, CT) (`SYS`, n=9) after prostatectomy. No statistically significant differences between these three clinical groups were apparent when considering pathological factors such as Gleason score or tumor stage (Table 1). As samples from older archived FFPE blocks are typically more degraded and fragmented than younger blocks, the distribution of block ages was similar in the three clinical groups so as not to skew or bias the results due to a block age effect. Fifty nanograms of RNA extracted from FFPE sections was amplified and hybridized to whole-transcriptome microarrays, interrogating >1.4 million probe target sequences measuring RNA levels for RefSeq, dbEST and predicted transcripts (collectively, `RNAs`).

[0220] Table 3 displays the number of target sequences identified in two-way comparisons between different clinical states using the appropriate t-tests and a p-value cut-off of p<0.001. At total of 2,114 target sequences (Table 3) were identified as differentially expressed in these comparisons and a principle components analysis demonstrates that these target sequences discriminate the distinct clinical states into three clusters (FIG. 1A).

[0221] A linear regression filter was next employed to statistically rank target sequences that followed a trend of either increased expression with poor prognosis patients (i.e., SYS>PSA>NED) or increased expression in good prognosis patients (NED>PSA>SYS, alternatively decreased expression in poor prognosis patients) (Table 4). FIG. 1B depicts a two-way hierarchical clustering dendrogram and expression matrix of top-ranked 526 target sequences and 22 tumor samples. Patients in the `PSA` clinical status category displayed intermediate expression levels for genes expressed at increased levels in SYS (n=313) and NED (n=213), respectively (Table 4). FIG. 1C depicts a two-way hierarchical clustering dendrogram and expression matrix of 148 target sequences and 22 tumor samples. These target sequences were a subset of the differentially expressed transcripts (Table 3) filtered using a t-test to query `recurrent` (i.e., `SYS`) and `non-recurrent` (i.e., `PSA` and `NED`) patient samples (Table 5).

[0222] The expression levels of these genes were summarized for each patient into a `metagene` using a simple linear combination by taking the expression level and multiplying it by a weighting factor for each target sequence in the metagene signature and combining these values into a single variable. Weighting factors were derived from the coefficients of the linear regression fit analysis (Table 4). FIG. 2 shows a histogram plot of the metagene expression values for the summarized 526 target sequences in each of the three clinical groups. This 526-metagene achieved maximal separation between clinical groups and low variance within each clinical group. Metagenes comprised of smaller subsets of 21, 18 and 6 target sequences were also generated (FIG. 3, Tables 7 and 8). The distinctions between clinical groups with respect to the metagene scores were preserved, although increased within-group variance was observed when using fewer target sequences (FIG. 3).

[0223] Next, Patient outcome predictor (`POP`) scores were generated from the metagene values for each patient. For the 18-target sequences metagene, this entailed scaling and normalizing the metagene scores within a range of 0 to 100, where a value of between 0-20 points indicates a patient with NED, 40-60 points a patient with PSA recurrence and 80-100 points a patient with SYS metastatic disease (FIG. 4). In contrast, Gleason scores for patients could not be used on their own to distinguish the clinical groups (Table 1).

[0224] Using the Nearest Shrunken Centroids (NSC) algorithm with leave-1-out cross-validation, smaller subsets of RNA transcripts were identified that distinguish `recurrent` (i.e., `SYS`) and `non-recurrent` (i.e., `PSA` and `NED`) disease (Tables 9 and 10). NSC algorithm identified 10- and 41-target sequence metagenes used to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. FIGS. 5 and 6 depict box plots showing interquartile range and distribution of `POP` scores for each clinical group. A 148-target sequence metagene (Table 5) was similarly used to derive `POP` scores depicted in FIG. 7. T-tests were used to evaluate the statistical significance of differences in POP scores between `recurrent` (i.e., `SYS`) and non-recurrent (i.e., `PSA` and `NED`) patient groups (indicated in the figures) and show that increasing the number of target sequences in the metagene combination increases the significance level of the differences in POP scores.

[0225] The data generated from such methods can be used to determine a prognosis for disease outcome, and/or to recommend or designate one or more treatment modalities for patients, to produce patient reports, and to prepare expression profiles.

TABLE-US-00001 TABLE 1 Clinical characteristics of different clinical status patient groups evaluated. Note Chi square tests for homogeneity reveal that the three clinical groups do not show significant differences in terms of patient composition based on known prognostic variables such as pathological TNM stage or Gleason score. Also, the block age of the samples was not different between clinical status groups; so that sample archive age effect is mitigated (i.e., older samples have more degraded, fragmented nucleic acids that could skew or bias results if not evenly distributed in clinical status patient groups). NED PSA Systemic X.sub.2 Tests for (n = 6) (n = 7) (n = 9) Homegeneity Pathological T2N0 2 3 3 p < 0.07 Stage T3aN0 1 4 1 T3bN0 0 0 3 TxN+ 3 0 2 Gleason Score 7 2 7 4 p < 0.06 8 3 0 2 9 1 0 3 Block Age 10-14 3 4 5 p < 0.9 Group (years) 13-15 1 1 2 16-20 2 2 2

TABLE-US-00002 TABLE 2 Comparison of differential expression between patient clinical status groups. Two-way comparisons for differential expression using the following statistical criteria: a) at least 2-fold mean difference in expression between comparison groups; b) expression levels >50 intensity units of a normalized data range (approximately the mean expression level across all transcripts in all samples) and c) significance cut-off of p < 0.001 determined using a t-test. Clinical Differentially Status Comparison Expressed RNAs* NED vs PSA 316 PSA vs NED 442 NED vs SYS 213 PSA vs SYS 194 SYS vs NED 269 SYS vs PSA 323 SYS vs NED & PSA 310 NED & PSA vs SYS 77 *Differential Expression is indicated by at least 2-fold change expression between mean of clinical status variable and comparison variable; also mean value >50 intensity units of a normalized data range and p < 0.001 calculated using a t-test

TABLE-US-00003 TABLE 3 Differentially expressed RNA transcripts identified from comparison tests described in Table 2. Sequence listings are annotated with the Affymetrix Human Exon 1.0 ST probe selection region ID, proximal annotated gene from RefSeq, and overlap with coding sequence (CDS). SEQ ID Gene No Affy. ID Symbol CDS RNA Sequence 1 3509278 -- NO ctggtccctctcctgatagagtttcaggtttgccctgatgatctagatgaagcaaagtgtggtgacacttcgc- tgaatgctctgtcagtgtgcctagaaatagag tctctatcagggccgtttgcttcctatcacactc 2 2750440 -- NO ggcatgatctaggctaactccctggc 3 3498665 -- NO tgggcaagagcttttgtatgtttccag 4 3159532 -- NO cccaacacggtgcagccgatttatttatttttccctcagcatttttaggtggattgactgggatgctttattc- aactcagggacgcaccacgaatatgttttttg 5 3521600 UGCGL2 YES tggcgccagcgaaagccacgaacgtg 6 3820597 -- NO gctgggcgcagcgttctgaggggatgtggggtctgggaggtgtctcgaggtgagagctccaagtcacgg 7 3955349 -- NO gtggcgcaatattgcaatacagctcactgctacagccccaggcttaagtgatcttcttgcctcagtctcccga- gtagctggaaccacaatctcataccaccac gccccacgcctggtaaatttttaaatgtttttgtaaagacagggtactgctgtgttgcccaggctggtct- ctaattcctagtctcaagcgatccttccgctttggcc tcccaaagcactgggattacaggtgtgagccactgtgcccagccctgctctaggttttcatttggatttg- ctgcctagtggaaggcacaggatggggcagtg ccttctgccagtgagggaggctccaggtagatgtcattgctgaactggagctcccctgg 8 3204523 PIGO YES tgcttcctcttctacgctggcattgccctcttcaccagtggcttcctgctcacccgtttggagctcaccaacc- atagcagctgccaagagcccccaggccctg ggtccctgccatgggggagccaagggaaacctggggcctgctggatggcttcccgattttcgcgggttgt- gttggtgctgatagatgctctgcgatttgactt cgcccagccccagcattcacacgtgcctagagagcctcctgtctccctacccttcctgggcaaactaagc- tccttgcagaggatcctggagattcagcccca ccatgcccggctctaccgatctcaggtt 9 3373899 SLC43A1 NO agccatggccgtagatttataaataccaagagaagttctatttttgtaaagactgcaaaaaggaggaaaaaaa- accttcaaaaacgccccctaagtcaacgct ccattgactgaagacagtccctatcctagaggggttgagccttcttcctccttgggttggaggagaccag- ggtgcctcttatctccttctagcggtctgcctcct ggtacctcttggggggatcggcaaacaggctacccctgaggtcccatgtgccatgagtgtgcacacatgc- atgtgtctgtgtatgtgtgaatgtgagagaga cacagccctcctttc 10 3707645 RABEP1 YES atggcgcagccgggcccggcttccc 11 3860354 LOC100127980 NO ttcagattcacgagggtaatccagatgaaggtatatcattgtacctggcccgcatcactcagtaactgtcacc- tttgatttattgatttacttgagatggagtttggt tctgtccccgaggccggagtgcaatggcgtgatctctgctcactacaacctctgcctcccaggttcagag- tgattctcctgcctcagcctctttagctgggatt acaggcacccaccaacatgcccagctaatttttgtatttttagtagagaggagctttcaccataatggcc- aggctggtcttgaacctcaaatgatctgcccacct tggcctcccaaagtgctaggattacaggctggagctacagagcccagcctgtcaccttgatttaaatgaa- tgcagctttcttggtgtcttgatgtttgtgaatttct gtggagtttgatactgctccttttgctgcttgtttttccagagtccccttatcacttgacgtgctgttat- a 12 2406772 MRPS15 NO tgtcgtgacagcctctctttggggccagcttctgcttttgcccccatctttgcagtacagggggtaaattaaa- caagaggatgcctgaatgaacgatatcctgg gttcttgagagacaagtgggagctgataattctgaaaattcattagtcaaagcatggagataaaggtggc- agcaggaaggggagaggcaaggagtagacc cgtgacagttttagaatcttatttgtgccaaaatactttactgcattggcttggacctctaatacaatgt- tgaattgttaaccatgatagcactgtatcctggtctaatt cctgaattgaatggctagtcttaccattaagaatgctatttgcggccaggc 13 3881324 HM13 YES ttatgaatttgacaccaaggacctggtgtgcctgggcctgagcagcatcgttggcgtctggtacctgctgag 14 3271321 -- NO aggagcaggtcgtcaagtccaccaggatggaatgctcagtaggagaaattgcgctgtggggccatttgaggcg- cctgtccatgcgggtccgtcctggccc ttctgaa 15 3316374 -- NO aggcattacgccagctcccggatgcctcagcctcgtgaattcggggtaggacgctcagggcccatggtcagca- cagcgggtgggtgggtttcagcgtggt cacttctccaggggtgcataattgagcagcttctcgatcaggtccacgtg 16 3333695 -- NO gttgaggagcttgatgctgcagtgagattgtgccactgcactccagcatgggtgacatagcaagactgcctca- gggggaaaaaaaaaaaaaaacaccaaa aaaaaaggtatatggaccctagttttggccaggctg 17 3930855 -- NO gtggctcactgtagcgtcagtctcc 18 2945934 CMAH NO ggacgattcgtttctatttgacccaagactgatgctgcgtggtgaaggagaggaactgcgttccaggcagagg- aagtccagatgcgcaagagcagagatg ggagggacagcacagtggcttctcagaattgaatatggtgttagacttctaaaagagctgtggtagaggg- agaaaactgtcaaaggaaatcagtaactgtta aaggaaaataccttaaacgtcctgttttcaggctgactaatgccttaggggagcaaatgagcaaca 19 2581405 -- NO ttggtatgtagggttcgtatgaatgaaacgtgactaccagggcagataatgaaaggctttcaatcccagagta- agagatatagggccaggc 20 2465840 -- NO atgtggcacaatttacgaaaaccaaagagaggctatgctgagtccctacaccaccaagaccgtgatgttctgc- ccactcgcctcctgatggcctgtggggat agaccagcttccagatttcacacagatgggctgtatggaggaggc 21 3431367 -- NO cgatctctcatggtgggctcaagtgatcctcccatctcagcctcccaagcacctgggactacaggtgcacatc- aacacacccggataatt 22 3458114 NACA NO gggccactgttcctcaagcatctaaagggcttccagcaaagaaaggccccacagctctgaaagaagtacttgt- tgccccagctccagaaagcacgccaat catcacagctcccactcggaaaggtccacagaccaaaaagagttctgctacttcacctcctatatgccca- gatccctcagctaagaatgg 23 3875254 -- NO ttctccctcagaccaagttaaactgtttttttcccaagagctaggaatcatatctgatcacactgggacttcc- cttcactgtcagtctaagagtttgcatttttgaggt ttaggaaaagggaaaaaaaaggaagaaagaaagaaattgtatctgagaacaaagaagctgccacatggtc- cctcggtatca 24 2515646 ITGA6 YES tgtgctcaccgatatgaaaaaaggcagcatgttaatacgaagcaggaatcccgagacatctttgggcggtgtt- atgtcctgagtcagaatctcaggattgaag acgatatggatg 25 3202904 -- NO tgagggcgttggaccacacacccttgaaaaaggcctcgccccgctcatctctgaagatcttcctccaacagtc- gacggtgcccgtgtacatgatgtcagctc ctttgcgccgggactgcatcatcgtccgccgccgcactgtgtcgaagggttag 26 2768304 NFXL1 YES ctgtccaccttgtgatcaaaactgtggacggactttag 27 3736631 -- NO aaagcggtcactggccatatgatgcggagatggttttatctgaggcctgagaaccaacagatgtgcctgcgcc- ctggcctgtgcagctgtgggcagatgtg tccccaggggcctgccctcactcgtgaccatgcaataccctgcaacataaacattttcttttccaaggat- ctgcaggggtggacatgatgctccaggcacag agtaggaagaaaagggggtgacctggggttcccagcaaacaggtccacctcatgctcactgcgtt 28 2787529 INPP4B YES tgtgccctggtatgtgaatgtacagccccggaaagtgtgagcggaaaagataacttacct 29 2980188 -- NO tttccccacaaattgctgatgtacc 30 3273235 -- NO caatattcactgtgaggtcaagctcctagaggtaaaaactcaaaactgtggcagccctcccccgtgactgggt- ccctctgaagtttctaactctcagagttgtc catactgggcatctagcgattcat 31 3402918 USP5 YES gaggaaaagatcaagtgcctggccacagagaaggtgaagtacacccagcgagttgactacatcatgcag 32 3529227 -- NO cgaagtgggtctccaaattccgcgcccaccccaccgcccgagaagcccactacgcatgcgtccgcaccccacc- ggcgccccttcctattgagcatgcgc gggagccccacctatttctctctaccgtttcctccccctacctggtaccccatccctagctcagccattg- cttttttttccacgaccctccgctgtttcttccgcga gcttcct 33 3839571 KLK2 NO ggagggaatggctgtgtcccacaggaataacagcgggatgcttcc 34 2697538 CEP70 NO gagactcgttgggtgatcatttcattgagatcaacctgaatgaccaggtgtaaagtgcaagagtaatatgcta- tgactga 35 2521076 -- NO ggatccatgccagacaacgcacattctgcagacactggttactccagtggctccttactggaaacatataata- tcagtgataagtgctgtgaagaaaataaaa caatgatgtgctggtatggatttttaacttttttatgtgatgaaccacagaatgatggttttaaatgtat- gaaatacatagaattgcaacagaaaccagttatgaaat aatgaagatattaaatatgacatctatattttagtaaagcattagtgaggactgtaaatgatctttaaag- aatttggcttaaatttaatctaaaattgctatcaggtatt tcacatcgctgtaatttttgcctgcattcgtaactgaagagataagtaaatgtcagaggttaagataaat- ctttttctttttttacctgtccatatttacaaacattctgc gttccgtacatagacgcctggataagaacccctgtgcaagaatgactttggtgctactttaaaaaaagtg- gttggggaagacctcataggaaatgacatcaat aatagattgcatgataacctatactagttcttactgttaccaatttaaattctaactgcttaaaagctaa- cacggtccttccctttttttgagcacctgatttgaagtac tttgagtaggcctcaagtgtcgtatgcaagta 36 2811029 -- NO ctgagttctgatttggagcagcctgtcgcaataccaaatcacctttgaataaacttatcctctcagcttttat- tgttcagaattgatttcgaggatagaaattccattt ccttgtcatatatacctgagccgttgcatcaaattgtcaga 37 2735920 -- NO gggtgtagcgcaccaagcatgagctgaa 38 3843767 ZNF135 NO aataacctagcatggggcggcactaaatggctgcaggaaagccgagtcttcttccacatccggcggctcccct- cggatgcgagcgctggcccagggtgt gtttacagaggtgagggcttcccgtggacccttctcgttgggagcgcttagcctcaggagcggattcagg- gcacaggcagaggacgtccacaaacacca caggaagccgccacccaggggcgtggaaaggcccaatgcctcgtctgggattcacggccggcaaagcggc- ccctccggaacgggacagcacagcg gctcacctctgcgcctctgggggtgcggggggagcctcgccctccacgctctctgggggaccgcccgccc- tagcccccgcctgggcttcgcgggtgga cggttgggggccccgggcgccccccagcgcgtagcttttctccttctcgtgggtcttctggtgctcggct- agggccaggctgaagtggaaggtcttccagc agccctgacaggcgtagcgcttccggccgccatggctgctgtggtgctccatcaggtgcgagagccacgc- gaaggcctccccgcactcgccgcaggca tagggcttcccgcgggacaagcccggctcgtcagccccagggccctgcccggcctccagccctgcgctgt- cgccggagctagagacgccctcgaggct ctgcccgtccccatcctcggggtgcggcctcttggttcccagtttcgccgtgcccctgtccggggcaggc- tgctggatgacggactgcctctgcgatccggt ggcagagtcggactccgcgtcctgggggtcctgcgggtccggggccttcccaggctgctcttcctcctcc- tcagtggtgcccgacgggggatcggcaag ggcgtccccagggggcgcctccgtaggcagctcaggcagcacccccgcgggggcggcctcctcgcaggcg- cacccagcgctctcctgccgcctccc gccttctggaacaaggtcagagccctagcgtgagcgccc 39 3895275 ProSAPiP1 NO tgggcactcggcattttgacacatgtcctgtcaaaaggccagagtccccagtgtcccctcccctccatctctc- ttccccatagaccccataaccccagaccaa agaggttctctaagcagctgtgaccaggttcctccctccccacctgccctcctagctccagcactgcccc- cgtggcagcccacttggacccccctaaaagg agggaataggaggagggcagggtgagtgggggcaatcctaggtggtgggggagtcatgctccctttctcg- gcacccccttgttggagatggaggcagca gacgtgcagtgccataaggtgccccagtccttctggaggcctgggctgctactgttggccaccctgtgtc- tagtgatgctctctgtgctcacctcctaggccat ggagcctgagggggcctgcaccaggtttgctgaaactgacagagcctgggctccagacctctctccctcc- tacagtgctctccctccctgggcagattggc aggacaagtgggagcagatggcctgcctttggctgagagggctacctgcccagcccctcccccaacaaga- tctcttggactcaggcctcagagcctggc ctggttgtgagtgtgtgtccctgtgtgtgtgttgcgggaggggaggactggggctggaagtccagcaccc- agggaagatctgtcctcctgttcttgggaagc gttgcctgacggcttctcggctctaccctcacccttctggccaggatcccgcagggcaacagccccatct- gcttggctgaccccacacccaggaccactgt ccggctctaacacagctattaagtgctacctgcctctcaggcactctcctcgcccagtttctgaggtcag- acgagtgtctgcgatgtcttcccgcactctattcc cccagcctctttctgctttcatgctcagcacatcatcttcctaggcagtctcttccccaaagtctcacct- tttcttccaatagaaaattccgcttgacctttggtgcac 40 4031098 CYorf15B NO tcacttaacatagtgccagggcatgcaattttgtttcttactctctggatgtgggatatgcgagtgtgtgtgt- gtgtgtgtgtgtgtgtgtattaagctttctgtttctg atgaaattttcatatgaaatttactggagataagattaaattagtggaaaaacaagataattttgctttc- tatgtagtggtcaccaagttaaagaattgtgccagtta ttaggcaagataggctttgagatttagggacagttaaattttacaccaacttagtgaacatgagacttct- acctagtgttacatttcatttttaaataagcaatttaaa aattggtaaatgatttgtttactttgattatattctggtataattttctgacaaaattatctgtgtcttg-

gtcagcattgttgctagaatatgtattcagattttgtctgtcca taattgagaacacagaaaaaatctaatttgactatacccatttacccccatggaaatgaaactatattct- atgaatgaaaaatgattttaataatgtggtgtattaca ttttcttcattcaagtaatgtaggccctgagtagagcatgttatgaatatttagttccttagtgttttct- cattcaagcctctcatattgaatgagtctagggtttggag agatgtttcacacagcatgtctcttcagtgcaagctgacagatatcagtgcacaattaaagaaacttaat- tgcacctttcaacttggagtataaattttgtatgtatc tatgtatatctatgtgtgtattttgtggtttaaggcttatttacataatatgtgacattttacctcagaa- attcagtgactgaatttcacagctgcttcccatgcatcttta ttatctatgtttctgaaaaactcaaatactaactaatctcttttcttcccttagctgttcctttcctgtg- gttttaaaaaagtgaccagaaactaggtctctattttcattg ctttgctgcatattcttttaacctgcttttatc 41 2927637 KIAA1244 YES gtcccacaggatttcgggaatcaag 42 3839575 KLK2 YES ttctgaagcatcaaagccttagaccagatgaagactccagccatgacctca 43 2566620 TSGA10 NO atccattgatggtttgatagtgggctgggaaggaaagctgtgttcctccacattaggcagcaaa 44 2959903 LOC728052 NO tcatttatttgacagtgcatgtctgcaatgccgtgctcatcaatgat 45 3100926 -- YES agtaacagctatccaccaatgtcaatccatac 46 3853655 -- NO gcaggcaatatctccgcacctttaat 47 3947544 -- NO ctgctggaacgacaccaactctttgcctcccatccttggttggatatgatttgaaatttggtaatgtgtctct- acttgaaacagatgcactgtttggatgttttcagg tcggtgatctacttgtccagtttgatcgctaccagaag 48 2466070 ZNF692 NO ggattagtccgctccactcactgtcagcattaagtgggggtgcccaagacggggtggatggggggcgccctcc- agacctctgaccacggcctcaccgcc actcgacccaactatgaagagcgcccccagctgcacgccaggacacgacctttccttcccctagaaacca- gtaaaggccgctgccctattcaagatgaaat gtgtggaccgcccccagcccagttgaaatttcccgtgaaagtctctcgccccttccccacagctccactt- cagtggactggagggcgcaggcctttgttctg actgcttctgtctgcctgcctcccacccgacgacactcacatggtagcgctgagcttcaacaccctgta 49 3065818 RELN YES ttcgataggtttgaggggaagctcagccctctgtggtacaagataacaggtgcccaggttggaactggctgtg- gaacacttaacgatggcaaatctctctact tcaatggccctg 50 3332183 STX3 NO ctgatttcactccagactggtgtggccacccttgtcttcagatgagaat 51 3681410 PARN YES ctgtcaataccagcaaatatgcagaaagctatcggatccaaacctatgctgaatatatggggagaaaacagga- agagaagcagatcaaaagaaagtggac tgaagatagctggaaggaggctgacagcaaacggttaaacccccagtgcataccctacaccctgcagaat- cactattaccg 52 3873342 -- NO gccacaggagggtttaaacacagcagtaatgagactttatttctgctgggaaaacattgccgttattgccc 53 2572055 -- NO gtgcctgagagaaaacggcctaatcgaaaacgtccgcggcatacatccattcttaaaacttgagtggctgctt- ttctgggtggaaaagagcggtatcagaca gggtgagcagtcggggaacggatgaacaaagacttgcaccgtggccctgatgcctttgttccgagttcta- ttcagttgtacttgtgcgttgttacaggacttta gaatgcagccctgccccccaacccccacctcccagggccgacctgtgctcctaggaaggcaaacctc 54 3434549 MLEC NO tggcacctcttgcatccaggcagtcttgtgagatgggggcacatagcactggggaaagcagaactccattctc- acctctattttgagcttcagtgctttatttca gtatgaggaaaaacaacaacaaactgaagtgcgctttccgtcctttcaaaggacaactgtcgggaaggga- gagccgagttgcgaggtaggaggggagca ctggcagggagagacattcttgactcctctcttccctggtgtgttgtgatccagggaatgaaaagaaatt- tgaccctggattggttctctccttggacttaagga atcttaccttttccttccacaaagttctcccaggcaaggaccagctgcccattctgagcccagggcagcc- tcttcaaccattattgg 55 4007482 -- NO tccaagcaggtcttcgtagtagagaacgaaccagccctcgatcaccaggtgaatgaacccacacactgcaaac- cagcacagggacagtcgccgccaagt ccccaatgggacaaccgcagcacgacctgacaacagccatgtggtcacgactaagacccctgtgacagag- aagaggccagccagtatatgccaggtgg ggcggtcattaggtacaaagttgtc 56 2751391 CLCN3 NO cccgagttagagcatggattcagttttagtcttaagggggaagtgagattggagatttttatttttaattttg- ggcagaagcaggttgactctagggatctccaga gcgagaggatttaacttcatgttgctcccgtgtttgaaggaggacaataaaagtcccaccgggcaaaatt- ttcgtaacctctgcggtagaaaacgtcaggtat cttttaaatcgcgatagttttcgctgtgtcaggctttcttcggtggagctccgagggtagctaggttcta- ggtttgaaacagatgcagaatccaaaggcagcgc aaaaaacagccaccgattttgctatgtctctga 57 2871645 -- NO ctctgtggggttcggttccactttgtagttcgggtttgtaatgtaaagaataatgggaaactggtctaattat- gagagttaagagagtagaggcctgtagttg 58 3629576 PARP16 NO ttagccataatagggcccggtacgatttgggagtgacatttctgtaaagaagaggaaaaatcatttttctata- atttgtaaagttgtgaaagagccactaccaca gtttttacattgattattggaacatttc 59 2545930 IFT172 YES tggtggctacaacattggcaccgtcagccatgagagccgtgtggattggctggaacttaatgagactggacac- aagctcctcttcag 60 2569734 -- NO ttcccttggctttggacatgtgagggaagtaggtatccgctgcctggggaaagtcaacaggacccctcctccc- cgtacctcttggtatacaaagctgagcgg tg 61 2832639 PCDHGA10 YES ttactttgaagtttgcggcatgatggtggaaagtgtaaatgctaaaacactgatgagtagaatttg 62 3113343 -- NO ggctgattgaccttgactggcctcatgtatgtgtctcaaagttggctggggctgtcggctgaaattccttagt- tctactccacatggcctttccccatggccagc ccaggctgagatctgagattgaagagggtgagaacagaaagtacaagatcttcttttgacttgaaagcta- gcccagaatcgagggaaataaaccccaccttt tgatggaaggagcttcaaagaatttgtagtcatttccaatccacgaagagtaggtacccactatttgttg- aataaagccctattgaaagctttttagctatccaga tgcaaattactggccaacctttgggtagaattataaaattctgcccaaaattctaccaaattactggtac- ttgtaaaattctaccaaataactggccaacttttggg tagaattgtaaaaattaagttgtaaataaagcctattgcctaacaggaacttcaaagtcagagaatccta- aaatgattgtgctacacagggccacatagagcac agctttgtctttttttttttgagatggagtctcgctctgtcccccaggctgaagtgcagtggcgcaatct- ttgctcaaggcaacttctacttcccaagttcaagcaat tcttctgtttgagcctcctgagtagtgggactgcaggcatgtgccactatgccccattatgtatttttag- tagagatgagatttcaccagattggccaggctggtc tcgaactcctgacctcaaatgatctgcctgcctcggcctcccaaagtgttgggattataggcatgagcca- ccatgcccgcccgcttcgtcttttcactggacta atgaagatacaggtgtggaatggtttcacagcatgcccaacctcatgaggcttgttgggtcagagcttgt- gccagatgccagtcttctgccttccagtcttata gttgttacgctatagccttctgcagtggatggtaacgtggccaaaataagcctttggttttggagtattc- gtaaaatg 63 3875673 -- NO gggaactaacgccttccagaacagaaatatgtggtccgatgagtattgaatgcaacttaaaatctagttggaa- tgtgatggataagaagagacccaaagtcat caacaagccttctcatgaactttcagtcattaaccttcctatatagtaaggacagaaatgatgatttaag- ccatcttaggcaaggcagtgctaacaatatgctttt gtaaagtcaccatccggtg 64 3959071 -- NO ttctctaattctaggcctgccgtttttctctgtgagtggacctgatctccttttgctttggctcccagagttc- cctattcgcttctccttgtcccctgagtcctgctctcc ctcctctggataaccccttccagcccttcacttctccctcctgttatttgctggaatggctaattggctg- acccccccacccagtccccatgggagaccccctcc agcaccagaagaggcagactaacattttctttggtagcagaatgtaaaattgtaaaatgtgaaagatagg- agagaaacatcattaactgttctgttatttattaac attttaatttatagaattatagacttaacagcaaaaattcaaacactgagggtcatcggtgaaaata 65 2864793 -- NO gcctattggcttcaagttgtttacgctttggtaggttttggcttgttccctcaaaggatcccttcttcatgtc- ctcccatgatgttgcaggcaagggtctcttgttatat gtggtactaactcgggcccacctggtcataatttc 66 2976430 -- NO gctcctacagtaacactcaatcaattcaccccactccagtgttcttcctgcaacatcactgatttagatggcc- cactctg 67 3862771 -- NO gggaatctattaatagtggaggaagtatttagtgggtggga 68 3192159 BAT2L NO tggatatatggcattgacccgcttgctttgatacgaaacaaaaaagcagacgactccttcatcccatctgctc- ctaccgtgactgtgga 69 3062031 -- NO gggtttgtcatgctacgctgtgccattcatgtgtttttttgctcatgctgttccttgtgcctggaaattctcc- ccctaattcccctgagcagtggatgcagtggatac cctccccagatcccccccaacttccctgagtgttggctaccaaaagctctgagtgcacccagggagctaa- gtcctcctgcccacaggcaataatggactga cacggggtagacttaaagaaataagaggcacatcaatcaattgaaatgtgtgggaccttacctggactct- gaatta 70 2505555 PTPN18 YES gagcagtacaggttcctgtaccacacggtggctcagatgttctgctccacactccagaatgc 71 2361309 -- NO gagccggacttccttgtcccaccag 72 3569829 -- NO gtactcgcctcctgcatggagcacgctcaggggtgg 73 2946327 -- NO ttactgttgctgtccgtaaactggaacctctgttcactcaag 74 2751432 -- NO ggaactcctcagaacttataatatgttgatattctttgattcccagatgaggggatgggtaataggatacatg- gttttccagacttgtttgaaaatgcaactattttt gggttgcagggaaggatatagtagaactcatgggaactggtgtttcttggaacatgctttggaaatgctg- ggttatgccctgttaactcttacatcattagttttta gcccaaaaggaaacagcaaataatgttttatatgagccacattttgcgttgattttcc 75 3907608 ZNF335 YES ggacgtctacggaagtggagcacctccaccaagagccaagaggaagagggaccagaggaggaggacgatgatg- acattgtagacgctggagccattg atgacctgga 76 2316543 -- NO atgagacctcagacaaagccaccagga 77 2453070 C1orf116 NO tgcgaccagtacagaccctgtcctggctgaacaagaagagacacatgctccacttgggagcctttgccaccac- gcaactcagggctcaagatgaatggga gggagagatttgagtccaagcatacatttatattcagtgttgtgccattgagttcccatgtggatcattc- tgaaggtgatctccacaagagggtgtgtgtgtgtgt gtttggtgtgtgtgtggagggggggccgctggatacatcactgaagctattgatataacacaatgagtca- ctgttcagaattttgctcttgttagatgttttcttac attgggtagagtccagcc 78 3119603 RHPN1 NO tccagctggcagcaagcaccgagcatgccctccccacccagaggacctccgggcaatgcctgtcccgcctcat- gctggaggctgcctcgggcacctgcc tgcccattaaagactggtcagacctgt 79 3908801 STAU1 YES cactgcagaaggaacgggcaccaacaagaaggtggccaagcgcaatgcagccgagaacatgctggagatcctt- ggtttcaaagtcccgcaggcgcag cccaccaaacccgcactcaagtcagagga 80 2525664 -- NO gaagctgttttaatggaggccgagagttggacaattttgtgttatggagaattctgggaagaaggaaagaccc- ggatgggactgtttattaaggcttatgactg gactggagata 81 2395926 CLSTN1 YES tacgggaaagaacatcaatataagctgaccgtcactgcctatgactgtgggaagaaaagagccacagaagatg- ttttggtgaagatcagcattaagcccac ctgca 82 2571145 ANAPC1 YES ctcaaaagtgtttattacatctgacctatgtgggcaaaagttcctgtgctttttagtagagtcccagctcca 83 2836006 -- NO ggatgtacactgatttggccctttaaatgacattataccaagaagttggtataagggagtaggagatgagaaa- actttttgaaaaatcatttggtgcatgctaag gtagcttgtaggacatgtggttttaaaaaattcatggattttgaagaaggatagggtggaagtaaaattt- agctgatagcatagggatcatttgtgatttatataga aaataattatatttttgagtgagaagcatcagacttaaatttttttcttctattttggttattaccaaaa- ggaacagagaaactctcagaattctttgaatcatagaatg ttagtgctggaaaggactaggaagtgacttgtacaaccccttcattttacaaaggatcagagagaattgg- ttagtagagtcccaaatctgcttttagaagtaata tggtgatcatcagtttagattcactgtaggaagggcagccctgttaaagtttgtcaggagaaaaagggaa- ggtatcactttttgtatgttcacccagttgcttctg tagttttcatacccctgttttctcaattttcttagaactgtctttaatggcccagctctaccagggcttg- ttgtctaaggacattaacttgtgctcccctcagggatgg gtttactactagctgtcagaaagctattgggtatcctaatgtgttaatagctgaaactcagctgtaattt- ctcctaaatacttcagcattttgcattctgtacattgtgg tgctttttccaccttgtattgttgtaactgtaagctcctagggggcagcaatttggtcttaggcgtgtac- cctgtttagtgcctggcaatgccatgtttatatcaagg tcttaatattacttttgagttatttctcccactcttcatggaagtgatgctccagccttgctaaaacact- gagggtcctcccgataagccaggcattgtgattccttg gcttcaagtgccttctgtcttccccgaaggtccactgagatctacaatcccccctt 84 2517773 -- NO tagcggagaatgacctacctacttgattaatgatgtctgcatgggcttactaagagggtgtggggaatggtgg- caggggtaactatcatcgagaatataggg caatgggtatattctaactttgcataactttgctagattatatatatctttactcacaataagcaaagtt-

gaacaacttaaaattgattccctgttttctgttttcactatc caactaggatgaactcttaagttcatacatatactttaaaatgggaacaaacatagcctgtcatgtcttt- atttaggctaagtgcatatgtatgtataagtaatgtgt atatccttcacttattaatagtgccttcatgaattcaaagacccttgtcacatggtgctcaggaaaaaaa- aagtgccaatattctttttttttttttctctaagaagtact agtttaggtaagtgaaattcaatagcatatcagtgctttaccttagtcactttttgtgttttgatcaccc- ttagtcatcactggagagaagagtttgaattcatttgtgg ttttgctttagtggcaaacctccttacagggatgagttgccctccattctccttgccatatttggttaat- ctaggccatgacctttgaggggaaaaggcacagatt gcaacttttctttcctgcttttgtgaatcaggccatgttcacgcagggtccttgaaggtgacttgagtga- ggaagctatataccgatgacttaccaatttttggtctt ataacattctctctctttttttttttttttttttgtagcatatggcttcctctactgtatgttggcattt- gccacttttggggatttgactcctgcaggtattttt ttttttttcttttgggggagtgtgacggcagtggatatagtcttagatgatgtttttaatagttcaagtc- cattagtgtcttactctagagaaaacg aaagactcactgtgtgagttttcttgccctctggttttcagaattctgtgtagtttctcaacat 85 3064957 -- NO aaatccacagccacatctttgaatg 86 3239181 KIAA1217 YES tcattctcaccgcagagtcaaaatggccgagcaccccctc 87 3629017 CSNK1G1 NO tcaccatctataaggtctcagagcagaggattattcatggtaataagtgggggtgtggtgcagccattccagt- aacaccca 88 3709453 -- NO ggtgggacttacaggtctcgctatagcaccagataaaatccatactacaccctatcattacctgggaatgagg- gtacaggagaaaacagtaaagcctcaaa aggaggaaattcgtaaagagtccttaaaaaccttaaatgatttccaaaaattattaggggacgttaattg- gataagacctactttaggaattcccacctaagcaa tgtctaaactgtttgctttgctgagatgggatccaaattcatgtagcaaaagaactctgatgcctgctgc- agctgaagagttacaaatgattgaggaaaaaattc aaagtgctcaagtccgtagaagagatcctagtgttccattacagctcttagtgttccctactctccattc- tcctataggagtgattgttcaaaatgttgacttagtta aattgtcctttttaacgcacagtacgactagaactttctcaatttatttagatcaaatagctattcttat- aggccaaatacaactgagaatagtcagactcattggca ccgatcgagataaaaatgtagttcctttaaacaaagcacaggttcgacaagcctttattaattcgtcaga- atggcagtcaaatctggctgattttgttggcagtat agatattcattaccctaaaactaaaatgtttcagttcctaaaaattgactacctaaattttacccaaaat- aactagttccattcctttggagggagccgtaactatctt ta 89 2732012 FAM47E YES ccttataagccaaagtgggtgaagatgaggtatggagcatggtatttgaaccccaagttgtggaaaaagcaaa- gagtagacgagcctctggttgaccctga ggtctcacata 90 2787588 -- NO ggttgctgcccttgagcattttgcc 91 3630110 -- YES atggagcacctgttcgtgtacctcc 92 3738711 -- NO gtagctaaacatatgcgtggggataaaaatcgggtggacaaggccagatacatgaagacatgctccactctca- tctgtgaa 93 3675240 -- NO cccggactgatgtgatttctttgacaattacaaaaaacaaaaaacaaacaaacaaaaaaacgcaaagcaatag- cagggaaaggacagtttgagaagacct gcaaggcctgccaggcggctcgcttgtgcagacacaaccgggacggctttgaggggacgtgcacacccaa- g 94 3458922 CTDSP2 YES gggacctgagaaagaccctcatcctgg 95 2694337 -- NO gaggaagacttgtgcgcccggcccacacgaaccatagagccgatctccggg 96 2990414 -- NO ccctccacacgtgttcagttaaagtgtgaggaataccctccccagacaaacatcacagatttccgaaatcaaa- cacgctccagcaagtgttctgcacacccc actg 97 3190328 -- NO cttctcagttgggtcaagtccattgacctttctgttacagcttgagttttgtgtcttacgtagaaaaggtgcc- cctgctctcactttctgcacagctatcaggtccag ctcatagcagttcttcta 98 3745435 MYH3 YES ctgagattgcaggatctggtggataaactgcaagtgaaagtcaagtcctacaagaggcaggcgga 99 3110076 LOC100134128 NO gtaaaagcgcggcaccgacaccagctgtgtgcagcagtggcggcggcggccgaaggagaaatagaacagcgca- ggcaaaagaagaaaggcgcgg gctgg 100 3471539 -- NO cacgggtccgctagctttaagtacaacaggatttccgtgttcaaaagactatactaagtgcttaatcaaatcc- cgtcacactaaagccaaatttagttctctagg aatcggagtctgcgtata 101 3918710 SON YES cagagcagcctgtagacgtaccatcggagattgcagattcatccatgacaagaccgcaggagttgccggagct- gcctaagaccacagcgttggagctgc aggagtcgtcggtggcctcagcgatggagttgccggggccacctgcgacctccatgccggagttgcaggg- gccccctgtgactccagtgctggagttac ctgggccctctgctaccccggtgccagagttgccagggcccctttctaccccagtgcctgagttgccagg- gccccctgcgacagcagtgcctgagttgcca gggccctctgtgacaccagtgccacagttgtcgcaggaattgccagggcttccagcaccatccatggggt- tggagccaccacaggaggtaccagagcca cctgtgatggcacaggagttgccagggctgcctttggtgacagcagcagtagagttgccagagcagcctg- cggtaacagtagcaatggagttgaccgaac aacctgtgacgacgacagagttggagcagcctgtggggatgacaacggtggaacatcctgggcatcctga- ggtgacaacggcaacagggttgctgggg cagcctgaggcaacgatggtgctggagttgccaggacagccagtggcaacgacagcgctggagttgccgg- ggcagccttcggtgactggggtgccag agttgccagggctgccttcggcaactagggcactggagttgtcggggcagcctgtggcaactggggcact- agagttgcctgggccgctcatggcagctg gggcactggagttctcggggcagtctggggcagctggagcactggagcttttggggcagcctctggcaac- aggggtgctggagttgccagggcagcct ggggcgccagagttgcctgggcagcctgtggcaactgtggcgctggagatctctgttcagtctgtggtga- caacatc 102 2792431 TMEM192 YES tccttggatatcacccagagtattgaagacgacccacttctggatgcccagcttctcccacaccactcattac- aagctcactttagaccccgattccatcctctt cctacagtcatcatagtgaatcttc 103 3828963 DPY19L3 YES gaagtggagcgagaaatctcattcagaacagagtgtggcctgtattactcctactacaagcagatgctgcagg- ctccaaccctcgtgcaa 104 3874927 CDS2 YES gttcattgtccccatatcttgtgtgatctgtaatgacatcatggcctatatgtttggctttttctttggtcgg- accccactcatc 105 3012468 AKAP9 YES ctggggtcagggaatttatcttacacacagtcagggatttgacatagcatcagaaggccgaggag 106 3541309 PLEKHH1 YES gatgtcatccggaaacctcaaggccaagtggatctgaactcccgctgccaaattgttcgaggggagggttcac- agacgtttcag 107 3543492 PSEN1 YES gcaagtgacaacagcctttgcggtccttagacagcttggcctggag 108 3878896 -- NO aacgtgctcagggagaatcagctggtttct 109 2669445 -- NO atggctaaaactccaatagacagcatgtagtgcttgggtgacagactttgggacaatcacagccactacaaag- tgaaaggggagaatccagaaagtacag agccagaaagggagagccccaaattctatgtaaaaactgcccaaatctttggctgaccactgaactatgc- atgcatggggcagacgctaagcaacctagct aaggataaaataactaagccgagaattgaggtagtgcctc 110 3953763 PI4KA YES gagcaacctggacataactgtcggctctcggcaacaagccacccaaggctggatcaacacataccccctgtcc- agcggcatgtccaccatct 111 3529048 -- NO gcccagtacctctccaagggttgtatatccggtgggggtggagggatcggcagaggtggtgtctcagcccttt- cgttcaaggagcgggttgatggtggtgg tgtaggaattgctgggtcttggaaactaggggcaccaggtactgcgttgtcccgaaaccactttagttgc- ccatgcttcaaggcatagcgtgtgtcaccaaac cactgaatgatctcaggccgaggtaaaccagtgatctgttctaacttttggtaatcctcacgccgtgccc- actggcactgtaaaaaaaaggatttaaggatagc cagctgctctttggttttgcgcttggtctttcgctggcgttgcatatctggggaaaggtactctgtgggg- ccaactctacctggtactga 112 3691111 -- NO ttgacgtggcttatcaacctttgtctcttacgtgctctttgttccggccatcgtcttgtttaacaaa 113 3845902 TIMM13 NO gggtccgcatgtacgtactgcctgcccggggcttaggagggtggcaccggtgctgggacacacgggactgtgt- cctcgccaccccccgccctgccccct gccagccagtgcagcttggatctcgggggtgtggggccctgtgccttcctgaagtgctggcagcccagtg- gcacctccttcaggcctttggggtattcccct agtgtgcccaagtcagcctcatattctgggcggacagcttgtctggacttcggagttgggggtggtcaga- caccacaggagctgtcacctcctgcggatgg gcaaataaatt 114 4009521 PHF8 YES gaccctgctttgaaatctcgacccaagaaaaagaagaattcagatgatgctccatggagtcc 115 3817782 -- NO catgcccggcccagtaattaggtttttttttaaaaagccccaaaccttaattttatttgcccctcatttcacg- gagctcccagcgtagtggggagaagctggccc agagaaccccacgtcctgcacagtgagggccagcccttggggaccccatgtcctgcacggcgggggccag- gccctggggccacgtgtgttcccccccc acccctattttctgccgcgtgctcgttctgctgcacgtggctgtcacttgaatgggaatttaaaaatata- acttaatgcacactgacttcccttgattggtgcaatta attatttgaaaagaaaaatatcacagtgttcttaaggactggcatttttccaagctgtgtcagttttgat- tgatgtctgacgccgtggctggcttctgaaagcctca ccagttctgatggcttattggcgacttcagtgtatccagcaatctctgctcatctttctgggggaatata- taatgatcagcaggcctgagaactcctacaaatca gagataagaaaacaaatggcccgatgaattcggcgtgaggggcttgagcagacgcgttacgaaggagctg- caggaacgaaagccatggttcagtgccc agcatcggtagaagtcagaggcagccagctgggagacaccgccagccccaggacggccacgtcagaacac- cgccaccagatgccagtgaggaggg cgcagctgcacgctgctcccagccggggtggatgcagggcggtgccatggccatggaaaaccgttcggca- ttttcttggaaacggaagcatgtaccctgt gccccagcgatgccactctgtgcatatttactcaggagaaatgaaaacatatgtctccagaaagattggt- acataagtgttcttagcagttttcttcacgagagc cccaaactggaaacagcccgcacgtccatcaacaggaggatagataaataaataaccatagatccacgcg- caaccgagtactgtttagaaatgaaaagga gcg 116 3948736 -- NO cgttgatcccacctccttgatctggtttctaagacctcatacaaactgggcccgttagtctttgctccctgat- actatctgataccatctggtctcac 117 3104724 ZBTB10 NO ctggtcggacggaaacgctccgccggctttattgtcgcttcgttatgtggcggagccgagcagtttagcgtgc- ctctcaccctcagcgcctgcgaagccggc 118 3364565 PLEKHA7 NO actggcctgtgctacttattaccgggcttgtaatagcggttcttgtctccatagcctgttgagtgttcccaga- tgtgactcacctttctgctgccctatcatgcag gcctactga 119 3540221 -- NO atgaggccggaaagatggcgaatttgcagggctgg 120 3458075 -- NO ccaaattttagttgtgaggaaacagacataccaagtattctttttagcaatgagcattagttctgtttttctt- aacagtgaggcaaactatgtatatttacattttgtag aatatttcctccaaaattggtttctgcatactttttgtttttgctatcactgtttgggcttagagtagta- tccttgaggctcgtctcatcttttttatttgttttgtttttttgttt gtttggttttgttctttgagactgctgcagtacaatggagcgatcccggc 121 3773290 -- NO caggctcatcattccttgttggatttcttcctggacttatttaaaagttgttatagctattatgaatgagctt- ttttaaaaattgtaattcctaactatattactggtgtag aagaaaactacagagctggtatccagctactttattgatttcttactgtttctattggcttttatttttc- attagtagaggttgagaatttcagtatttcattcccagatcc atatctcatttctttctcttgttttctttgcgttgctggagcctccaaaacagtctggggtaactgctat- gctagcaggcctcctcatc 122 2835195 FLJ41603 NO ttatcggtgtagcagagaggttcccaagactcttgactggtcctgggagtgggtgtgaccaagtcatagttct- ggaatgtgtgtaggcaaattcagaggctgtt ccagggaagaggggattttgatactgtgttaggtggggtgtgtgaggctgttggcagcaggtgaacagct- actgctgtgttctcaggactagggaacaaag gggtatgcaaatcatagaggaaactctgggaaggcggtgataaggcctggtgggtggggaggttagggaa- tggcttgctttcctgtttctggttagaaggg gagccagggggaacccccagtggtttcaggtggcccctgaggtcctggaggcagccgtggatgtgatgca- attggctgtgggaccttagatgtaggaca caacttcagtgttcccatccagaaagacctcactcacagggttgtgctgagaatgacgtggggctaagca- tgcagagctccctgtaaactgtgaagtgtgat acaaatgtaaatgacagcagtgatctcggggtggcccccggcatgctgccctcccccacgcccatgcctg- tggcagcaaaccttgttcatcagtatagcttt ctttcctgtaacccaggatctaccttggggggcttctcaatactgcattctatgtagccagcctctttaa- cttggtaagtgagccaccccattctagaacctggaa attggagcccctcaaaaacagttcctgttcaaggaggactgacctgctggggcaatgttgggtgcagtgc- agtccctgcttggggtggtcatgtctaggctgt tgctctgggcaaagataagagcaagattcacagaaatgggaaaatgtgaccaagtgtgatcttaacaact- gacaaagtttgtaaccaacccaagttagaatg tgtgtcaaacaggaggtagtttagatatgcttccaagaacatgtctgtgttataaccatagtgcctaagc- agtgagctctggtttttgaagggcttttaagaa 123 2988321 FOXK1 NO aggctctccgggcaaatcagaaggccacgagagagagaggagcggggagagtggtgaggaggattcgtctctg- actgatgaacctcgccgtgcctgtc tgtcacatccaagtctgtgccagctgctgggaggtcagactcctgccctgagaa 124 3632941 UBL7 NO

cccagcaagttgcagaggctactgcccttgggaggcactcatgaaggtgcctccatctctccatccccaatat- acctgatggtcaactctc 125 3855574 -- NO ggcagcaggggtcagattttcctcatggcctctccagcaggccagcccgggtttctcctggtggctgggagcc- aggagagcggctcccatgcagagtgct ggtttcacatttgtgggtggcccatccgttgaggccagtcacgtggccaggcccaggaccagatgggaga- ggaccgcacaagtgcagcgtgagctgtgg gaggtgtggctgaccacgcttagagagtgtggtgccaggaaagatctgatgtgtcaccattctatatctg- tgatgggcagacgcaggcaggtcaaagggg ccctggggacttaccgagcccctgcctattggccaggcactgtgattgtcctcggtgccatgtgccatgg- aagccctctcagaggtcgaggggaggcagg tggagacagagcctctgtaggcctttcaagctgtagccccagagcccagaggcagccgaattcatgtgtg- cagtcagagagcacttagtgggcactgtagt caatcagtgagcgcttactggacaccacaggcagcaagcatttactgagtacctctggcagttgatgcat- acttcctgagtacctgttcatagcaggcttagct ctggatgtggggtggtgaggaatcccacaggctgaggggtggcctgggagctttccagggggcctgaagc- aggaggggctgcctgagtgggtcagca gcccagcccagtgccctacgcagccctgcccacacccccaacccagcctctgtctccccagtcccatccc- ccacaccctggtccctcctactttgtgcctcg aggacactgccccgctgccctcctcacttcccagcgtctgctgtcccctccgctgctgctgcccggcagg- attgctctgtgtctcatccacgtttgtccctgca gagttcctcgcctctccctggaaccgccagcctcatgccgcatctcagaggctttttttttctctctttt- ttttttttttgagatggagtctcactctgtcacccaggct agagtgc 126 2648215 -- NO tttcgcagttgccaaaaatggtgccgtaaggctttcctggaattaagtagtcagaggtatttggttagcagat- gctttgtaaaacctaatatattcccactatatttc ctttaaaaatcaagggggggttaacacctttagattgtcatgttttattgagaaaaatccacttctctga- aactccctattactg 127 2714009 -- NO atctgaggccaaggataaattcatcaactgggtagccaccactatagaagaagccaaccacaatcaatgtcgg- ctatgcgtccagctgccagaggccgcc aggaatgagctaccttgaagaatcgtccgtgacaacatttctgaatggctatgtcactatcaatggggcc- acaacaacaacacttgcaatccaacctgaactt cctatgaccaaaccaagcaatctatttatgcccaagtcaagtgaaaggtgaactccaccttcaccatgca- tcaaaagccttggtatcctgcccaatatgcctgg aacggtatatattgggaacctgctgtgctggtggccggattccatatagctcc 128 3342827 -- NO gagcaggcagttggcaaaccggaaag 129 3494235 LMO7 YES ggaaagaagccgcaggatcagcttgttattgagaga 130 3816344 SF3A2 YES ggagctacctggcacatacgcaggggaagaagc 131 2340361 DNAJC6 NO cggcggcttcgcctcgcccggcgaagcttctctccggtggccgctccttcttttccctcctctttgcgtcatg- tcgggcacttaatttttt 132 3557286 HOMEZ YES agagcagctggctatccttaaatccttttttttacagtgccagtgggcacggcgtgaggattaccaaaagtta- gaacagatcactggtttacctcggcctgaga tcattcagtggtttggtgacacacgctatgccttgaagcatgggcaactaaagtggtttcgggacaacgc- agtacctg 133 3911399 -- NO attttcctgcattcacgatggcctcc 134 2612381 EAF1 YES cagcagtaaaatccaggcccgaatggaacagcagcccactcgtcctccacagacgtcacagccaccaccacct- ccaccacctatgccattcagagctcca acgaagcctccagttggacccaaaacttctcccttgaaagataacccctcacctgaacctcagttggatg- acatcaaa 135 3354739 -- NO tttgagaggttatttgtccatgggatgctcgtgttaaaacaaaaa 136 3434425 RNF10 YES taatcgcaaacgtgaactttcctaccccaaaaatgaaagttttaacaaccagtcccgtcgctccagttcacag- aaaagcaagacttttaacaagatgcctcctc aaaggggcggcggcagcagcaaactctttagctcttc 137 3734620 KCTD2 YES aggaagcggagttttacaacatcgcgtcccttgtgcggctggttaaggaaaggatacg 138 3802333 LOC728606 NO ttcagctacgttgtcccagcacttcactggttaaccttttatgtccaccatttgtggatttcacagctacttg- tcaatggtgaatattgatcatcatcattatctactga gctgctaccatatcccagctactccttgcatgttgttcattattttctcaacactcagcatatttgcaat- atgttatgtaatatcacagacaaggaaactgaacgca gaaatgttttatttcttgccaaacatcacatgaggatgaacaatgaaaccgatttgaaaccaggattgtc- tgattccaacatctctgggtctttttcactctgatatg 139 2896736 -- NO aggatctagctctcttgctcaagctggagtgcagtggtatgatcaaaactcactacagcctgcaactagtgat- cctcctgcctcagctatagctaaaactatag 140 3053930 -- NO ttggcacactaactccacttctagacatctatcctaagataataatcaacatataaaaatgcacatacaaata- ttgactataagaataaaaaaatttcagcatttaa gctgtacaggtgaatgtttaaattatggtacacccatttgtgttatttattttaaaaaatttttttgaag- tataactatgtagaaaactgtcctagcataatgttaagcat cgttcccaatgtgttt 141 3459700 -- NO ctaaggtgagacaggtctgtgaatccggggtctctgtcacttggggaaaaaaaacgggcagaaaagctctgaa- gtttgaaacacataaggaaaatctgcta tctgtacccccaccctcccaaaatatagttgacgcccccgcgtgatgaagagtttatgggggtggaggct- tggaggagatgtcactgcgcctgggagcttgt gtccgattccgggaggtggccgtgtccgagtgcgtggttgtacatttccgaaggtctcagtttctctcac- tttcagcccgcga 142 3223562 MEGF9 YES gtctgccagttgcgatgccctcacag 143 3888086 ARFGEF2 YES ggaaaggccttgacatggcaagacggtgtagtgtgacgtccatggagtccacagtgtcctcggggacccagac- aactgttcaggatgaccctgagcaattt gaggtcatcaa 144 3378887 TMEM134 YES ggattccagccgaacttccatccgcag 145 3280240 -- NO acctttccctgaggttggataggcactgctccccttctctgtgcccctggctcccacatctaatgactcctgg- cacttacgacactctcattcaaattttctagcc atgcaccttaagccc 146 3379391 -- NO ttttgtacatgcacttgcagtattgaggttaatca 147 2351210 FAM40A YES gcagcacccacctcaaaagccaaaacagactcaatcaacatcctagcggacgtcttgcctgaggagat 148 3758440 -- NO gtttcactatcgagagtcggactgcttttggatttacgtggctttgtgggatgcggtatgaagatcgttgcat- tcaagtttaccgcctctacttcactgcagaatct gactgccgtcagatctgtatgac 149 2617213 ITGA9 YES tattgggctggaaccatcaaagtgctgaaccttacggacaacacctatttaaaactgaacgacgaagtgatca- tgaacaggcggtacacc 150 3677835 CREBBP YES aaccagaggagttacgccaggccctcatgccaaccctagaagcactgtatcgacaggacccagagtcattacc- tttccggcagcctgtagatcc 151 2332491 -- NO atccactaagaggcgcaagttggctgcctttccagaatcctctgattttcgttgatccaaggggctggaactg- agcttcctttttcatgccaagtagggtccaaa caacagagaaacataaagctcttcctttctccccaacctcaccagcccttaccatggctggcttcccagt- gattcattcaaggcaaca 152 2932426 RBM16 YES tggggtccggccatctaatgtttccagtagttctgggattattgcagcccaaccaccaaatattctaaataac- tctggaatattgggaatacagccacccagtgt gtcaaatagttctggacttttgggagtgctacccccaaatatacctaacaattctggacttgtaggagta- cagccaccaaatgttccaaatactcctggacttct gggaacacagccaccagctggacctcaaaacttaccccctttaagtatccctaatcaaaggatgcccaca- atgccaatgttagacattcgtccgggactaat accacaggcacctgggccaagattccctttaatacagcctggaattccaccccaacggggaatcccaccc- ccatcggtacttgattcagctcttcatccacc accccgtggaccttttcctccaggagatatttttagtcaaccagaaagaccttttttagctcctggaaga- caaagcgtagacaatgttactaacccagaaaaaa ggataccacttgggaatgataacattcaacaggaaggagatagagattaccggtttcctcctatagaaac- cagggaaagcattagtagacctccccctgtgg atgttagagatgtggttgggcggcctatagatccaagagaaggtcctggacggcctccactagatggtag- ggatcattttggaagacctcctgtagatataa gagagaatcttgtgaggccaggtatagatcatcttggtcgaagagaccactttggctttaatccagagaa- gccctgggggcatagaggagattttgatgaga gagagcatcgggttctaccggtctatggtggtccaaaa 153 3273785 ADARB2 YES taaagtaagcatattgtcaaccttcctcgctcattcaagcacctgagtcctggcatcacaaacacggaggatg- acgacaccct 154 4015409 TSPAN6 YES tgagaaggctttgaagcagtataactctacaggagattatagaagccatgcagtagacaagatccaaaa 155 2428715 PHTF1 YES ggccacagcgttcagttgatgtggttgtatcctcggttttcctactgacactttcgattgctt 156 3261500 NOLC1 YES gtctgccaaggtcccagagcgaaagttacag 157 3144008 NBN YES cagacttttgactggcgttgagtacgttgttggaaggaaaaactgtgccattctgattgaaaatgatcagtcg- atcagccgaaatcatg 158 3527425 PARP2 YES atctgtgaaggccttgctgttaaagggcaaagctcctgtggacccagagtgtacagccaaggtg 159 3836942 -- NO taccaggagcccatggatggcgtgacccagcaggcagcacagaatgtacttgccaaggcgggcaaagagtaaa- cc 160 2746889 -- NO ggagtcaaacgtcagagcctgagacctttgatgaagggtcacatcgccagagctcagtgg 161 2853401 -- NO gctgagagctagctttgctttataattttgtacttactaaaaaattaaataacttataaatggaggaaaactt- ggatcagttgatagattttgggggagttagtgaaa tttcttgaggggattttcaatcgaatgcttttattttctgtggcagtaatgatctggttggtttatctca- taaataactgatgctgctgctttttgtgttctttgatgtctca ccttatgtttttactaagtaaggacagcaatggattggcactgatgc 162 3593678 USP8 YES tgtcctgcgcaatgagcctttggttttagagggaggctatgaaaactggctcctttgttatccc 163 2466363 -- NO tgataattggtgacgacaaggaaattaagacgattgctcaaagagatgca 164 2961018 -- NO gatcttccacacaaagatcaggtgaagaaatctatgcagctatacatgctaggacctgagtacaccatccctg- caa 165 3307825 -- NO ctgaggaatcttaaatctgggtataaacgtgaaatggttttattttttccttactgggtctccagtcatacag- tgtaaaacactcctaacctctgtactttcctctgca gtgcagtcctttaagaatcccttggtccgatgtaactttgccgccact 166 3375666 FTH1 NO gacccgcagggccagacgttcttcgccgagagtcgt 167 3510380 C13orf23 YES gcagctgccaccgtttctggaatgaacctgctgaatactgtccttcctgtgttcccagggcaggtctcctcag- ccgttcacacacctcagccatcaataccaaa cccaacagttatcagaaccccttcattgcccactgcacctgttacatccatccacagtacaaccaccact- cctgttccttccattttttctggcctagtgtcactgc caggtccttctgccactcctaccgcagccactcctaccccaggacctacaccacggtccactcttggttc- cagtgaagcatttgcttctacttctgcacctttca ctagcctccccttttccaccagctcttctgctgcttctaccagcaacccaaattctgcttcattgtcatc- agtttttgcagggctccctttgcccttaccaccaacat cccaaggcctatccaacccgactcctgtaattgctggtggctctactcccagcgttgccggtccacttgg- tgtgaacagtcctcttttgtctgcgttaaaaggttt tctgacatccaatgacaccaatttaatcaactcctctgctttatcctctgctgtcacaagtgggctggct- tca 168 4026959 HCFC1 YES caagccagccaacaagcggcccatgtcctc 169 2888352 RNF44 YES agagcagctcccgtcgtaccgctttaacccggacagccatcagtcggagcagacgct 170 3320634 USP47 YES gagaaattgagcgcaatacatgcaag 171 3752442 -- NO taggtgcatgacactgctcagtttgatgtgctaatctgattccagtaaagagaattgctgatttaatgttgag- gcccgatcttccacaggtcctaaatgtttcccaa aatacatggatagcatacgactgggtttttttaaaattatcccaggtcaagcatgagtatctc 172 3188731 NEK6 YES caggactgtgtcaaggagatcggcctcttgaag 173 3303115 -- NO ctggaccaaccactacttccgtgtttcaagttcatttttagcacatgaacatgatcactgttagccagtgaag- tagcttctgactagatcattgattagatctcaca aaaaaccaaaaatagtatatggaaaccaagatgagagcaaaagaaaacgttacctgagtaggcagctaaa- acatattttgacattatttttaagcagcattcat aaggttcacgga 174 3820685 ILF3 YES ggttctggcatttatgacccttgtgaaaaagaagccactgatgctattgggcatctagacagacagcaacggg- aagatatcacacaga 175 3882554 -- NO ataatgggatggcaaatagtctccccagcccagagttcaatatcctcctggttgctggctgagcttagactag- aattatgttgagtttccaggacacccatttta cgaatgttattttgaattgcctgttgtatgtgataata

176 3054154 -- NO ctacacgctgccgaggaaaacgcaacagacatggcaggtgcctcacgacaagaaacacttacaaatagaatca- aaactgattcaagtcataca 177 2624472 CACNA1D YES atccgcgtaggctgccacaagctcatcaaccaccacatcttcaccaacctcatccttgtcttcatcatgctga- gcagcgctgccctggccgcagaggacccc atccgcagccactccttccggaacacg 178 3652530 POLR3E YES gactgctgtgtaagctatggtggcatgtggtaccttaaagggacagtacagtcttga 179 3980537 ARR3 YES actaccacggagaacccatctctgtcaatgt 180 2808239 -- NO cacaggtgaattgtctgggaagtcaggatgttgcacagaagctatgcaagtcatagattagaaaagcaagaat- ccacattcatgctttccagcatagatgag gagatactttttctccaccttcttagattcagtggctgggcagagagtgctgtgaattcatctgacaaca- ggcagattaacacgagaaaaggaatataagtttttt attttttatttttttatttttttgttttgagacagagtgtcactctgtctcccaggctggagtgcagtgg- ctcactgcaagctcccacctcccgggttcacaccattctc ctgcctcagcctcccaagtagctcagactacaggcgcccgccaccatgtccagctaattttttttatttt- ttagcagagacagggtttcacctcccaaagtgctg ggattacaggcattagccaccgcgcccagccaagttttttaatgtttaatctaatgtgcatggaggcatc- atagaaagaactgaatatccaaaagtgtggtgaa atttgagactttagataccatcttaatgatagtggcaggaggcagacaaatcctagggagacaagggtgg- gtccctggtgaaaccccaccttcaaaccaaa gacagatttaagcatgaaagccaagctacaagtctccagtaaatccatggaccggattaagaatctctc 181 2811059 -- NO ccatcagcttgtgactcatggcttagctggtctcaatggggaacaaaccagagagtctatggatcaacacaaa- gctataactgc 182 2858392 -- NO ggcccagcttcatggatatacaaactatacattcacatgggttccacacctagatgggctcttacatcatgta- gctggtcctacctgggagagagc 183 2779739 -- NO tctgttcacggagcttagttctacttcctga 184 3298972 -- NO gttaactataggtaggggacagagaaaggagcagagttaatgtatgctattgaagctgagttgctatcagtct- gaactagactttgaactcagcatg 185 2933580 TULP4 YES gaaactggccacgtgcgatgcggacggaggcatattcgtgtggattcagtacgagggcaggtggtctgtggag- ctggtcaacgaccgcg 186 3528128 TOX4 YES caactaggccaaaccagtacagctactatcc 187 3528025 -- NO cggcgctacgttaacttcgactatattaatgagcatcacgatcttcattttcatgatcccgtagtcctcgcgg- tcgtagaaaatgaaaggaaagcagccgttaa cacaggaagagcgaaaaaaggacattttccctggcgatcgtggc 188 3581134 AKT1 YES gatgatctctccacggtagcacttgaccttttcgacgcttaacctttccgctgtcgccccaggccctccctga- ctccctgtgggggtggccatccctgggccc ctccacgcctcctggccagacgctgccgctgccgctgcaccacggcgttttttta 189 3676391 -- NO tgggccatctcctcggtacaggtcagctgccgccggcggagctcctcatctgtctcct 190 2319003 -- NO ccaagagcccggaattttcattacaactttcaaagagagcaagaggaggagggaaaaagatttcacaaaagca- ttatcaaggccccaacccaggatgccc tgctgtacaaccaaaatttgtaagaggtcagcctttcagggagtcaaaaacccagcatgtgga 191 2858313 -- NO ctgcagagcaaaatatagaggcactaattttgttatatttgcagcccacatactgtaataccagatttgctcc- tgttgttct 192 3048750 -- NO cgggaaacttcggaagacagctgtgcctggctctgtggctgcatgcagtgcttcacttggccagcagaggtca- gctgtgccgagctgccccagccatgag aagagaagcctgcccttgctggcaggtggctatggccggcccagagccttcctgcccagctcctgcagcc- ctgctgcctgggatcaggctgggagatgg gccttcctgaccgccagccttcctctccccgagcacacgcacatgtagattcggggggaagctgcctgct- cttccttagaggagccggggcagctatctgc tggtccctttctgaacaactgttga 193 3360848 APBB1 YES tgaggaggggacgttgaccttccca 194 3387192 CWC15 NO gccaagagtggtaatggcgtctgtatgatcttcggagcctgctgcatcggacctcggc 195 3893880 -- NO actccgcagggctggcacttcctgagggagtgggggctcaggcttcagacggactttattaaaatgtgtagtt- tgtgtgaatcatttcagtcaaaagtttcagct atactcggccgttaagacaacttaatga 196 2393792 KIAA0562 NO ggaagggctgccatagttgccgcagt 197 2395248 RERE NO tcacagcagcgagcatccagggtttgcagggacgatgttacagactctgttttctgcctggcgtttcacttgt- gtctgctcctagcctgtgctctgccagcagc acagacatctgctccatcagacctcttccattttgcacagggagtgcaggaggtgaatgttcactttctg- ttctccagtgtcactgttctgtttccacgggatgga aagcgcatgggcctgtgtccattgtagatttccttctagatttctgtgtacacacacttgattgttctgg- atgaatgtcttttttaatactccgaaaatttcatcatcta agaaaatgattccatacaaataactcagcacacaagtgacccaggacatatgcctgccaaagggatgtgt- tagaaggctgccttctcatgcgcattgtcactt ggatcttgtggtgaggacggccccatctttcttgccacagattgaggccacttttgagcaagggagatcc- tggagttaagacaggtgttgggggcagcctgt attttaccctaggggcaggtctgcatggtgaccccacattgcactggtaaaccatttgagtcccactctt- catcctggaagtgggaactggagtcccacccac agtgcattcagaaagcatgctgtgtgggggctgcttctcaggaggccaggcccttctgagcggaaccgtc- ctggagagagcctgccctcgtttccaggctg cagccgtaacgcactttc 198 3403226 UNQ2963 NO ctcacccttgaggcccgggcacttc 199 3920956 -- NO cccaaatgtgagttgcatcaaattcggtaaatgtagagtatgtttgttttctctgtacacaatactgacgtca- gtgctagtgcctgcctaaactcagacaccagta gatccttttccaga 200 3970256 REPS2 YES tttgaaaagtactatcaatgaagccttaccaaaggacgtgtctgaggatcca 201 2724115 -- NO gcaggccttacttatttccacaggaccttataagctcatacactctattgcttattacgttactggaatctat- ctaagcagaaagaggctggcccaccttctgttat ctatgtttctatactctttggacttgcta 202 3351955 MIZF YES caaccacatgcgctttcgtcacagtgaggaccggccctttaaatgtgactg 203 3133234 PLAT NO ggaattctgcttcactcgcttaacatatacacaacacctgtaacatacaaggcaatgggctaggtgctccaga- ccgggaaaaggagggacaggaatgcttg gtctgatgggctaatatggcatttagagaagtaccaaggtacagtggagccggtcacaaaagggcagact- tgt 204 2723089 -- NO tttgtggctgttaataggaaggatgctggt 205 3102652 -- NO tgtggcaaactaccacggcagatgtttacctatgtaacaaaactgtacatcctgcatgtgtacccctgaactt- aaaaagttgaaaaaaaaaaaaaaagaaaca aataggctgggcatggtggctcaatgcctgtaatcccagcactttgggaggccaaggtgggaggattgct- tgaggtcaggagttcaagacctgatatagtg agacc 206 3392531 -- NO ttggacttgaatgactaggagaatgactactctaatgaacaaaaatgtaaatgttatatgtgggtttagtaag- ggaatgcaatgaacttggttttggatatgttaaa cttgagttatcactggaacattcaggtagaaatgtttagaaagcagtttgaaataagagtttagtagaaa- ggttgagagcagcgctgcagatacagatttgaaa gtcatctgcaaagagatgtgtcttagcgttctc 207 4015009 -- NO tggaggcggccctacacctggcaatggaggt 208 2596170 INO80D YES gatgagttgccggatgacattgccaatgagatcactgacattccacatgacttggaattgaaccaggaggact- tttcagatgtcctgccacggctacctgatg acttacaaga 209 3591676 -- NO aaaacctggaatgctgtaggacatgtacccactgaggcggatgcaaggagcgatggagaggaagga 210 3680412 -- NO tttaccccttctcggtgacatttgc 211 3906169 CHD6 NO ctgcttgacttactgggtgatattgggctacaactgagactcactttgctcctgtgtaaagtggggcaacagc- atctaccacggagggttgaagatttacgga gatcatgctaagacagtttgttccaaactcaaaggaaatcatttgcaaacaacagaaaaggtcagaaacc- gtatacctggccaagagagatcccttttacgct ttgtttaatgtttcatgttgtattttgggttttcccatttactggattctgagctccaaaacaggaatca- cattttatgttttcttattttaaaagcaataataataactagt acttattgagtgcctactgcttaccatgttcaaggctttacatgattatcttgtttgttcctcacaacca- ctctgaagatgggctttgttattcccattttataggtgag gaaaataaggctttaaagcattaaataatttccccaagattatccagctagtaagtgacaaagcaggaaa- ccaaaccaaggacctttttctctaggggctgaga 212 2803102 -- NO ctatatgtagctaccctgtggcctccccctaaggtaaccactttactttttagtagtgaagaatgtctaaaat- ataataaaggtatatctagaacacaaacctcca agcaggaacaacccattatctctcctttgcatgccctgtcaatggcttcaaggtcaaagctagctaagtc- tctgagtgtgtagggagctgacatcttggtgaaa agtccttcagtacatgctagatcatagctgacttgcactatccttccaaactttggaatatctctctggt- attggattggttacaatggaaacagaaagattctgat catacaaaataaagattttcatttgtgagctcaaccattggatctgtcatcttccattagtagaaaaaat- gaggaaatcaaatactttgttttgtttttaaccacgcag agaaggaagagagtagagtgtgggaaattgatatatctgccttactgccccagcccctccctctggagtg- tgcaagtggtcagaagtcagcaaattacttttc catcatatttggccccaaactaccctggtgagtgaggagaaagggaatcatttgataaggtttggaaaat- agcatctgtttttcttagtgtttctggatgaatttat caggcatccggtaatttgtactttctgttgaaaactataatagaataccgtgcatagacatgaaaccttt- tggtattagtcagaagctacatactgactgctgttgg agaagaccacatttacagtcaagggtagaatcatctgaaatagtttcccctggaaaaaaaaaaaacatgg- ccatatatgcctacatagatctcctctttgcttca tgaatttggaactaaacctgggtgtttagataattccagttctaggattttctcaccttgagtttattcc- ccttattcttactagttcagtttggccactgtacatatgga gcttactagaggcaaagcactctgtgaggggcaatggttataca 213 4025793 -- NO ttgtgtctgctccaagtgcgaaccctccatgcactgcagagaacaccagaaggagaggagcactacctgagct- tctccttccgggtctaaaggtggaacttg ctttgcagcacccagcatttcactgtactgattcctttttttggatcaccacctcctgcgtttagcagcc- catatgctgggctcactcagctatacactgcttg 214 2616236 FBXL2 YES aattttggaggctgcccgatgctcccatttgactgacgcaggttttacactttta 215 2959832 LOC100128757 NO tccggtgcttacctctaactgataaaactagctccaacccaccaccctccactgacttccttcgcactcagcc- cactcgcacccgggtgaataaacagccttt gttgctcacacttagcctgttcaagttgtctcttcaattagatgctcgcataacatttggtgccgaaagc- ccgggataggggaactcctccggcagacctctcct ctatcctcccggtacccacgttctcccatgcaagagacttccctcgccctcaggacctcagaccagctcc- gcgagcactccggcctctgtctatgga 216 3072195 -- NO ttagtgtcgtcaggagactccctccatcagaattactcaggctgattgttttgagtcctgggacccagttggt- atccagaatcttggcttgtttgcctaggaacc 217 3757471 ACLY YES gggtgtcaacgagctggcaaactatggggagtactcaggcgcccccagcgagcagcagacctatgactatgcc- aagactatcctctccctcatgacccga gagaagca 218 3986531 -- NO gagggaggaattacgtggtgaaggatgaagtgaacagcggtgcttggcatataagccagccctcaaacaag 219 2696767 MSL2 YES cttcctgtagctggtgcaaagactatgagcagtttgaggaaaacaagcagttaagcatcctagtgaactgcta- caaaaaactatgcgagtatataacacagac tacactggcacgggatataatagaagcagttgactgttcttctgatattttggctttgcttaatgatgga- tcattgttttgtgaggagacagaaaaaccctcagatt catcctttactttgtgtttgacacattcccctttaccttcaacctcagaacccacaactgatcctcaagc- tagtttatctccaatgtctgaaagcaccctcagcattg ctattggcagttctgttatcaatggtttgcctacttataatgggctttcaatagatagatttggtataaa- tattccttcacctgaacattcaaatacgattgacgtatgt aatactgttgacataaaaactgaggatctgtctgacagcctgccacccgtttgtgacacagtagccactg- acttatgttccacaggcattgatatctgcagtttc agtgaagatataaaacctggagactctctgttactgagtgttgaggaagtactccgcagcttagaaactg- tttcaaatacagaggtctgttgccctaatttgcag ccgaacttggaagccactgtatccaatggaccttttctgcagctttcttcccagtctcttagccataatg- tttttatgtccaccagtcctgcacttcatgggttatcat gtacagcagcaactccgaagatagcaaaattgaatagaaaacgatccagatcagagagtgacagtgagaa- agttcagccacttccaatttctaccattatcc gaggcccaacactgggggcatctgctcctgtgacagtgaaacgggagagcaaaatttctcttcaacctat- agcaactgttcccaatggaggcacaacacct aaaatcagcaaaactgtacttttatctactaaaagcatgaaaaagagtcatgaacatggatccaagaaat- ctca 220 3188391 -- NO caggggtacacccacatctattgtattagacaaatcacagagggattgcaacagaacacagatttttctcact- gttttttctctggttgatcgggatgcattatcc accagaaaacactgtagacgactcactcaccaggaaaagagcatatgccagttggaataaataaagggga- agagtaaggaagaggctgtagaattatttta taaattatcaagtcttatgagccaggtgc

221 3846196 -- NO tctggccaatgcatattacttaagggcaatgtcgtggccagctgtggtggtctgggctctccctctgtatcgc- ctggggaggctgctgaggtgactttttggaa gaaaacacgggatgagtgtatgatggtggctgtggagaccacccaaaatcccggggttgggggcaatagt- gaatgaatgggaccatctgcgtgggtccct acacgagatgcttg 222 3070747 -- NO gagctcattctgcgtttcttattgcttg 223 3821522 -- NO gtagataaccatttgtcgctgctttttctgttaagtgttcaccacttgtatcattggctggcaatacctggtt- tgtcatagttt 224 3875001 -- NO agctcctccccagaataccatgctc 225 3279450 C10orf97 YES ccaaagtttaattaatctcctgctgacgggacatgctgtttctaatgtatgggatggtgatagaga 226 3541293 PLEKHH1 YES tctttctctggcctggtctacaagaatgtcac 227 3547709 TTC8 YES cctggaacgtctttgaaactccctggaactaatcagacaggagggcctagcc 228 3875261 -- NO gccaaccttggtttgtgcagtttaaggaaaaaagccatctccataacatggaagtgcaagatgaagcagcagg- cactagtggggaagctgcagcaagttat acagaaaatctagctaatgatgagggtggctacactaaaaacagattttcaatggagacaaaacaccctt- ctattggaagaagatgccctctaaagctttcata ggtagagagaggtcagtgcatgggcttgaaagaacaggctgattctcttgctagaggccaatgaagccag- tgagttta 229 2584791 -- NO cactggaagaatataggttggctcagacagtccataggaaggctaaataaccacgctcaggaaatgggcctta- gagagtgggaagagaaaatgtatctaa acttatatctcagtaacagcttgataggacattgtcactagcagtgccaccactaggtcctca 230 3204563 KIAA1539 NO ttgccagcactctgaacccatgcgggctaatgacctgcccatcctg 231 3356165 APLP2 YES cgagactctggatgttaaggaaatgattttcaatgccgagagagttggaggcctcgaggaagagc 232 3650891 -- NO tacactccctcagggacagtcttgccatttcccgtttttcattcttataaacaatgccctggtgcaggggtca- gcaaacttttctataaggagtcagataatctttttt ttttttttgtattcccttttggcaatttgtttaattgagataaaattcacataacttaaaactcaccctt- ttggtgtatacgattcagtgctttttagtatattttcaagattgt gcaaccaacaccactatctaattccagaacatttttatcaccccaaaaaggagccctgtgccaattagct- atca 233 3829699 GPI YES actgaagcccttaagccatactcttcaggaggtccccgcgtctggtatgtctccaa 234 3971251 CNKSR2 YES cctcttatacctagaagtcccacaagcagcgttgccacgccttccagcaccatcagtacacccaccaaaagag- acagttctgccctccaggatc 235 2359255 -- NO agttgtggaggcatgtttataagcagatctgagttttgccacactggaatttatttat 236 2811000 -- NO ctgggtctaggaagccaggtactttgtgctgtttcaacaagagctcttctgctttaactagttt 237 3391986 -- NO gctggagaagttcgtctgggacaaagagctctggcctcatgcctgtgggtccagcagtcaaactgggacagac- tatgtgaaaagggacccac 238 3888361 -- NO agcagcctcccgcttagcggagagtgggatgagcacatgcgcggccgacagggaagagtgaatccagagcaga- agtcaagggcaagactcgtgggg gggggaagaaagggacagaagccagctcccagcaataaaggtcgggttattttgttcttttgtgacatgc- cctatatc 239 3897502 -- NO tctcctggggacttacatagctgtttggtttttcaacttgattgaagaaagttattcgggggatctgtccaat- tcacaccttctgttccctgatcaaatactttagggt caaacataaggttttattgatttttgctcaagcaaagaattaacatttttgataaggaactgtaatggca- attataaggtaatatggtgtatggtaatattatgctgcc agaggaaacatttgactatgattaaattcaagcccagtactgggtagctctagataattaaagataattt- tatccattcaagtcccctctgttaagctgcacattga ca 240 3235381 DHTKD1 YES acagtatattgtgagcatggtcataaagctgccaaaatcaaccccctcttcaccggacaagccctgctgg 241 3286657 -- NO tccagtgaggccacatcatgacttcccccatgaagacatcgaattcacggctgccttcacctttgtcctgtca- atgtctgatctttcctttcaattacagcacgag gctggggttcca 242 2714224 MYL5 YES tggaccagatgttccagttcgcctccatcgatgtggcgggcaacctggactacaaggcgctcagctacgtgat- cacccacggggaggaga 243 3331851 GLYATL1 YES tgaaagtagagcattcgagagcactcctcttggttacggaagatattctgaagctcaatgcctccagtaaaag- caagcttggaagctgg 244 3356559 -- NO gccatggttctcttgtggtcagctcttgttctaatccttagcgcccatttggaaaccagttatggggaaagca- caatgtaggactcttgggactctgcacctgac tggctggctttccaagatcactgagatggctcttcctccagcatagaaattgatggctggttatccagac- agcaacctcttttgcccatgtgcttggtgctctgtc atggcgggaaaagtaactatgcacagatcatgattatggtattagattgggtacacatgaaattgctagt- atgcacctattttgatgtatgaaaatatcattttcat gagattcatcctaatttatgctatgtatggggcctgattgccctaacagctcatc 245 3636325 -- NO atcagacaccgcctattcaccagctcatctataaaaccccctgcatttcaccgcagaactggaacctatt 246 2539613 -- NO tccattcttgcgcttaaaaactgtacctaactccctcccatagcagacagaataggataggcttcttccctac- ctggtgttcaagttctaccactgccctcctccc ttcccccatttacctctctagaattaccaggtatctatgcatacatgaattctctgcttccattagattt- acttgtcattccccaaatacaccatgcacttgcatattag caaagccaagtttgtctttcacaaatgcagaggttaaataagagttaaggatgaaggtaaaccaaacttt- atttatatactatattttaccaaatatgatttaaggat ctctaggcagtgttgtctta 247 2860647 -- NO gcaatgtggaccagaccatcgacaacccctatgccacctttgtcaagatgctaccggataaggattgcctcta- cgccctctatgac 248 3143676 MMP16 YES cccgatgcggtgtacctgaccagacaagaggtagctccaaattt 249 3492475 -- NO tgggctgaccacagactttaccacaaa 250 3698355 ZFHX3 NO gtccgagcctccgtactgggtgcaatgaaagc 251 3364564 -- NO attggcgtggttcttccccaggataccttatagagtctagtgaacttttcctgtttgtggaaacaatcaggct- gggtttaaatgaggacttgtctctatttggagcat ttgtgagcgtgtaaggaaatgagtgttt 252 3101645 ADHFE1 YES agggagcttttgatgcctatgttgctgtcggtggtggctctaccatggacacctgtaaggctgctaatctgta- tgcatccagccctcattctgatttcctagattat gtcagtgcccccattggcaagggaaagcctgtgtctgtgcctcttaagcctctgattg 253 3015159 ZKSCAN1 YES agttcatggacctgagatgctcgcaagggggatggtgcctctggatccagttcaggagtcctcgagctttgac- cttcatcacgaggccacccagtcccactt caaacattcgtctcgg 254 2686624 IMPG2 YES atacctttcaagctgcatggccctcagcagatgaatccatcaccagcagtattccaccacttgatttcagctc- tggtcc 255 2897644 -- NO atgttgggtcccaccttacatttagtttcatgtccccttagtttcctccaatctgtgacagtttcttaatttt- ttcttgtcttctgtgaccttgacacttctgaagaaaaca tttccttgatatttctgatgaaaatgattattatgtagaatgtccttcaacttgaattggtctttttctc- atgattagaatgaggttctgggtttttggcaagcagagaac agaagcgatactatatttttctcagtgcgtcatatcggggtcatgatgtcagtgtgtcttatactggtac- actaacccatgtctgctaggtttctttccaatacagtca 256 3909740 -- NO ggtggagcaagagccctgttggctgatgg 257 4049026 -- NO ggcacagaagggcaaattccgcacattctcatttgtggg 258 2321582 -- NO atggagccagaaaaacgcgtgcagcagctcatc 259 3304498 ARL3 YES ggcttgctctcaattttgcgcaagttgaaaagtgcaccagaccaggaggtgagaatacttctcctg 260 3533002 -- NO tactgaatgtgcttggttttggacag 261 3568039 PPP2R5E YES ctcttgctgccgctgcagatccagtcttcctcc 262 3764440 RNF43 NO tgcggaatttctcggcacctacctgtagtatggggcacttggtttggttgcagagtaagaaggtggaagaatg- agctgtacttggttaagcagttgaaacctttt ttgagcaggatctgtaaaagcataattgaatttgtttcacccccgtggattccagtgggcccgaca 263 3790080 NEDD4L YES ttgggaaagcagataaccctgaatgacatgga 264 2658005 -- NO gtattatcacatgactgccaggtgc 265 3029676 -- NO gtctgtgggtggatagatccattaatggataagtaaatgagcaatgcttcctgggttgaggttttggattact- gtggtcatgcactgcattggagatgaggtgga aaaaccatc 266 3390272 -- NO gagtgggcactaggaaacggattcaaagaggcgatgaataatctgagttttacaggtttaacaggaaggcata- acattgtaagcaaagaaagaaaagatatt ccagacaaagcatatgtgg 267 2642810 DNAJC13 YES ctggatggagtaagagcctctggtaatagagatgtttgtgtaaaaatgacaccaacccataaaggtcagcgat- gggggttactcagcatgcctgttgatgag gaagtagagagccttcacctcaggttcttagctacgcctccaa 268 2811129 -- NO gatgagatattaactgctgcactgg 269 3070222 AASS YES tgagaaaatggtggatcatagaggagtacgggtagtggcatttggaca 270 3907114 TOMM34 NO cctgcctgaccttacccagagaagccatgggccacctgctctgtgcccgctcctgaaaccca 271 2790942 -- NO atgttcccataagcaacagcctgtaaattgtcacatgtaagtcatctaataagtttagaacaatgaacaactc- attttctgaactgggacaaacaaggaagctaa attca 272 3043075 -- NO aatcagtgttgcctggtggatagcaaatcaagtttcaaggttacaga 273 2354095 WDR3 YES ccatggtgaaatggtgggaccttgatactcagcactgctttaaaacaatggttggccaccggactg 274 2713294 -- NO tggattgcgtaaaggtggggacctccagatcttccacgggaaaggtacgtttttcttgttgatattgtgaagt- gtgtatggggttgtactttggcaccttgtagtg agtcagtttccccccattggtgatcattgccaaatca 275 3220577 KIAA0368 YES agatgttgcatcaaagggccttgggttggtttatgaactaggcaatgaacaagatcaacaggaattggtttct- acacttgtggaaacacttatgactggcaaaa 276 3531076 SCFD1 YES tgttactcgtattttggacaatcttatggagatg 277 2505303 RAB6C NO gcaggaagaaaacttcgagttacaggtcaggaaaagc 278 2644040 PCCB YES gagatcatgcccaattatgccaagaacatcattgttggttttgcaagaatgaatgggaggactgttggaattg- ttggcaaccaacctaaggtggcctcag 279 2938530 -- NO gagaatgccggtggggccttcagcagcagcatcctaacagtgttgca 280 3625346 CCPG1 YES gaggccctactatgcaaaatgatggaaggaaagaaaagccagttcactttaaagaattcagaaaaaatacaaa- ttcaaagaaatgcagtcctgggcatgatt gtagagaaaattctcattctttcagaaaggcttgttctggtgtatttgattgtgctcaacaagagtccat- gagcctttttaacacagtggtgaatc 281 2971361 -- NO ctgcctagtattgtgctacagtaccagacaaaatcactttagggttttggggttttgtttttttaaacaaact- ggtatgtaatataaacttaggaaccaccaccac catctcgagtatcaatgtttcagaatggaggcatagttcagtgaaaaaaatgccggcattggttttagtt- ttgattcttgtttcaccagaaagcatggtggttggg ggagctgtcaaagtactccggatagactcagcgccattaaataagctcaggcatatacggccaggagcaa 282 3026661 TRIM24 YES aagtgtgagcgcctacttttatttct 283 3108906 -- NO ctgcatcgaaccagcgacctgggtgcctccccacccaagacggacctccacatcgggaa 284 3649134 MKL2 YES ccagcagccctttatcaataaggcctccaacagtgttcttcaatccagaaatgctccgcttccatccctgca 285 3729183 CLTC YES ttattgaagttggcacaccacctacagggaaccagccct

286 3900156 C20orf74 YES tcccaacaaaatcgtggcccaggtagcttgcgatgtccttcagttgctggtttcctactgggagaagcttcag- atgtttgaaacctctctgcctcggaaaatggc 287 3907653 NCOA5 NO tttcctctttggaactcttgtgttgtt 288 3102604 -- NO ttggtcttcacgcactgggtgtgtctgtaaatacagcgctgtccacggtgtctgtcctgcttccatcccaaat- tcaggctttagcttaaaacatctttagtttaatttt ttaaaaaattcttttctttcccccagataaaatcttaatcttttgcactagactgttagccagggaaa 289 3863282 -- NO gaagtgtttccagacatcccaattc 290 2920506 -- NO gcttcttcgtggtcttttccattat 291 2319069 -- NO ctgaagcagggtgcccgtttctacaccaaagagcggcaaaatgaagaa 292 2573693 CLASP1 YES gcttctgggcctgcagaacttactgaa 293 3022667 SND1 YES gtgcccgagtagagaaagtcgagtctcctgccaaaatacatgtcttctacattgactacggcaac 294 3570810 -- NO atgtgggtggagatgatctttgctttgagaacaggattcattatgtgggctggtcaggagtgggaacaagagc- aggaaggccacaggggattgagagtact tctgtccccaacacactcatcaaggacgtgcaatcgggggccaaggctcattatggtgattttca 295 3847162 -- NO tggccagctccctagtttgtgcttactatacctggccacgcctccctacctaaggccgctggcttaaccctag- gggcaggcagtgttagatcagacccagac cttctcatcccaccctcatcacatcggggagaggggactccaggggcgggaaggcaggcgtccctccatt- tggccagggtgggcggcgaggaggggg tcactctgcaggaacactgagctctgaacacctct 296 2535304 -- NO tcaacaacatgaatggcggcaacactaggagacatcc 297 2697615 -- NO tgcagtggtactattttagctcaatgcagccttagattcttggact 298 2931795 -- NO agatggcatgctgcacaagggattcatggttacagcgggcttgtgggactggggctctccaatacgtggttgg- gtttgtaaagaaatcaga 299 3011882 STEAP2 YES caggttattgaacttgcccgccagttgaatttcattcccattgacttgggatccttatcatcagccagagaga- ttgaaaatttacccctacgactctttactctctg gaga 300 3464921 -- NO cctgataataagaggaacgaggacagctcagaaagtacaagtcaagaagccctgagaggggagtgaattcagg- aaaccggacatttcaggtttgcctca gcattgcatgagtttgaggaacaagaaaagatgaggatggattgtgaatgatctcgaatgtgttttgaag- gtttttggaggtatttggattcaccctaaga 301 3541610 -- NO aggtcgatgggctcagaattcactgacaggttcagatccagccgagaagtggagcatgtatggtattagtggc- atttgaaggtcattagtggcataactattgt agtgtaaattcaagttttattggtatattgtgtatagccctgcaga 302 3872499 -- NO ttaggagccatcaacgagttcacgccggagaaagacctttcaagtgtggagaatgtgtgaaatctttcagtca- taagcgcagccttgttcaccatcagcgagt tcacagtggagaaagaccttatcagtgtggagaatgtgggaaatctttcagtcaaaagggcaacctcgtt- ctacaccagcgagttcacactggagcaagac cttatgagtgtggagaatgtgggaaatcatttagttcaaaaggacatcttaggaaccatcagcaaattca- cactggggacagactttatgagtgtggagagtgt gggaaatcttttagtcataaaggcaccctcattctacatcagcgagttcaccctagagaaagatcttatg- ggtgtggagaatgtgggaaatcttttagttcaatc gggcaccttaggagccatcagcgcgttcata 303 2470335 -- NO aaggcgttcgttatgtgggatatgctgttaccactgaacttgaagttatcaaagaagt 304 2887649 -- NO ggtaagtggattgacctctaaactccctagaagggctgtagctttgaaggtggacatttattgggctcgcacg- tgacacttattggggctaa 305 3522210 -- NO gtgagaacctacatgttgggtgcccacc 306 3674221 -- NO agtgagcgtttgagtgaaccagccacagtctctacgtgtcatccaaggagcccggcacagaccccgtgtcacc- cccatgtcacccgcagaccccgcgtca cccatagatacgcaca 307 2560167 -- NO gggacacagagcagttgaggatatctcttttctttcactctgttctgaaatctgcctcttcccaaaggtactc- catgacccctaagatactcactctg 308 3041159 -- NO ttaattcagcacaactcaccattcccactggaaacatactggcaattcacatcttccaaacaagg 309 3183335 FKTN YES gaggcactcaggccaaaacaggaaaaa 310 3204049 -- NO gggcgccatcggatggggcaaagagatccctgaaaacgtattgccgggggacggggacttgcaggacaagaaa- accgtgggagaat 311 3393003 KIAA0999 NO gttgattgtaaacccacagtatctagcagcgttgtgccaaattgcccttgtgtttctctccacccaaaatatc- acagctgctttcctcacatttggttcatccgtgtg ctgttctttt 312 3598130 -- NO gccaagtacaaagtgctgtcccatatattacctttatcatcatgacaagcacttgagatggtaattaacaact- ccactttaagtctgagaataatgaagcaactg acccaaggctccaaagacagtgaatggcagagatgagattcaaacccaggtctccctgactcgaaagccc- acgctttcccccaacaccatgttcttttccttc cctgtcagaaagggaaataccaaaaacaaatgagggtatgtatgagggtttggctggagccccagtcagc- caaagtctgattccaagtggactgcagggt ccgtgttatctcccttgggcacaatctcaaaagcccagaattcagctgccttgctaaccttccatcccag- tcttagtgagaagctaaactaacttctgggcctca attacagcagatta 313 3681604 LOC728138 NO tgccatagaccctcacgtgtttgttgcattaattggataattcaaaatataaagtattatccagtttcaggat- aatattaagatctaaaccaatgaatgctctatgaa aagttgtagattaactgatcccttaaaactaaaaacagcgtcttcataagcttctactgggggcagctac- cactttcttcatcacatttcttatcctcaatagctgtg ggcaatgccaaaatagc 314 2410882 ATPAF1 NO gttggcccttcacctagttgactcagccctcgatagtctagagcccaccccctcctcaggaactcaagagctc- agcatttataatgagcagttggtaatgagtt gccctatgtgcttgtcgcaagcagtcacagagatgagccctattacttgatattcaggaacaaaggtacc- tgaacattctgataattatctcagcatacttgagg tttccttttttaagtgttcgaggttataacaagagacagccaaggacctacaagacagttgacttgattt- tgcacagtgtaacagcgcagttgcattctggccact ttgaccttatagctcccaaatgatgagtttgtcatctttatgaactcatgacaggataataagcttgaag- acctgctgtagttagatatgggctttaatccttcccag gcaccagtcagctgaacaaaagcataagccaaacatcctgtttaaactgtagaataaccagatattccca- tcaggttaaagacttcatctagatgatgccccc cagagatgcctttagtgtaagtagctggcttggggtatcagcaaatttcaggtatagttagataaacagg- tacagggcctgcatactattaaaccatagtttgtg gcacccgcttttcta 315 2821250 CAST YES agggccagatgatgctatagacgccttgtcatctgacttcacctgtgggtcgcctacagctgctggaaag 316 3134070 PRKDC YES gattggagcaatgatgtaagagctgaactagcaaaaacccctgta 317 3888286 -- NO agctccagttacatgggcctgttaacatggcagctttgtctataagcaaacccaggagagaaagacatagcag- agatggatgtttgaagtctataccttccac cccctttaaagagaaagtaacaccactccttttctgtgtcccttggggacactacctccatgtctggtca- catggctggactttacagcagataagcatactgtg gcctgagaccatgattgtatgctttccttctgctgacctttacaatccctcaataaattgagctaacaca- gggaagcttttttaccaaataactgtgttgcatcatcc tccagtttgcctggtgtccttaatcaatggaaggggaataagcaaactgagttttcttacaccttttgag- tatagtgtttttgccatcatagatgtggctcctcataa ttctccaacttttatattaaaaaaccaaaacctcaaaaattgtagttcatgtcagtcagtgatgactcat- cttagaagtattttgtttttggatgtgtgaatgtgcatag ttcttaaagtccaacattcatgtaataagacatcttgcatataacaatgacccttacgtctaagatgtta- aatagatcctaagcctggtataactttattcaagtatcc ttatttgcccctaaaatgtctttaatacacattacttgggttatttcttgaatgaacatacaggtatccc- aatttctgatttttaagagaatggggtcttgctctgtcaccc aggctggagtgcagtggtgcagtcatggcttactgcatccatgatcctcctgcctcagcctcccaagtag- atgggactgaaagcacacactgccatccctgg ctaatgttttcatattttgtagagttgcagccttgctacgtgacccaggctggagtgtagtagctattca- caggcatgattgcttgaaactcatggcttcaaggga aactccca 318 3919790 -- NO gcagggagtgcagaaaccttggagaaagtgagagattttccagccaaagggaactttgtgtttccctggctgg- gactcttggggatctttttcaggttttctgca gtttttctgaattgagctttaaggcaactggatggattttgaact 319 3948965 -- NO cttagctgttccagcggcccatgtttaaaagaatgtgcttctttttccaagtatttctgccgcttgcatgcac- tgagcttctttggaaaggagcaccatgcaggca tattttccagacaggaccggatttgctcgttactcaga 320 2738676 -- NO ctgagacctgaagcacgagagccaagtgtgtaagcaagtcgatgggattgggaagaagtttaggctgctaaaa- aatttttacataaagcttgataagaggg gatattgcatgtgaaataaacagaaattcagtaaatatggtggaagtgcaggatttaggggatggaaaaa- aatactagtttcaaaaattgaggctagaagtga aggtaggggccagattatgaaaagccttgtaagcaatgctaagaaacaatagatgtcagaaggacatgcc- accatctaaaaagcagtcttgagaacaagta attggataaaggtgacctgactaggtatttgtttttttaagtaaattgtgttaattttgttaggtgtaaa- aatggcattagggtcatgttggggaaaaaagaatctctt tcttacagatgaaattacatggtctctgagactgcttccaaaaa 321 2929182 -- NO tgggtgtaaacattgatgatccttctaatactctgtcctcttaatttctctaagttctctttctagtgatctt- gtctcccagtgtggtgggtatattctggctagaccag gtcattgtttatggtggcagcccctctgtcatctgaatttaagcgtcccattttttcggtactagcatgg- ctcactgc 322 3004581 -- NO gcaaatgttttaatgggccctcctaccttacctgacataagataattcatactagaaagaatacctacaaatg- tgaagaatgtggcaaaagctttagtgtattctc aacctttactaatcataaagcaattaatactggagagaaatcttacaaatatgttgaatgtgacaatgtt- tttaactaggctgcaactcttgctg 323 3300811 C10orf4 YES tttggatttaggtggcgagtagaaaaa 324 3426258 -- NO atggagattaagcaggaacttcaagaaagccaagctcttcttggtagcacaccagagtctgaagg 325 3645807 -- NO agtggaatctctgaaactcaggtgtggcatcaacaaag 326 3976960 -- NO caaatcccgggtggcagccataatccccaaagatgacccccaccccaagattccaaagaagctagtggtggtg- gaagcaaaaggaatgcagcaaggtc agggtttcattgtccaagccggcctgacacctgccgccctgcccttgcccagtgcacaccctagaccctg- ggccggcctccatgcagctggaggccagaa gacagcaacccatatctttgcaccctcctccatgccccatggcctgcctgcccagaaagatgccaccttc- acagagccagtgctgtcgtctatatcattt 327 3981121 OGT NO ccgtcgccgccatttcaagaccgtactag 328 2391399 CPSF3L NO gtatgcaccggcttatgaacccaccaggctctgtccgagcggcattgaaatggccagagtgggacaggctggt- gccctcagagcgcttggagcggccag agactcgctggagctcccggggtgttgccgggcagggaggcaggggctggaggggagatgggccagctct- ggagggtgcctggttctgggtgtgggt cagggaagaagtgaaggttaaatcagcgagtgacaggtgaaattccatttctgacaaagattatgggttt- gtctgtgtctcactcgaatctctggg 329 2748879 GUCY1A3 YES tgcgaattggactgcactctggatcagtttttgctggcgtcgttggagttaaaatgccccgttactgtctttt- tggaaacaatgtcactctggctaacaaatttgag tcctgcagtgtaccacgaaaaatcaatg 330 3063716 -- NO gtgagtggttagagaacaatggcaaacaaagggcgaggcgtttaagcttctgtagagagg 331 3361874 TRIM66 NO tgggcttccgtgatcccgttttctagtttggggtaactgagtcttgaatgctttactagtccggcaatctttg- gacttaggcttctgccctttgagactcacatgact ttctggtttggggtctggtcatttccctttcaatttttgaatctccttctctgttcagttggcttggcaa- agtaccctctgttctcatg 332 2812780 -- NO tctggaatgaaacagcgtaatgagatgagccctga 333 3065419 -- NO ctacaaggatactcaggtcagaaaggcccaggagtacctacctcattcagcaacagtccagtcaaaatcttcc- tccccgacaatggcctatgaccagcctgt tctacacattcctctctgg 334 3077669 -- NO aagagcccttctcaatggcttaacccatagagccc 335 3652961 -- NO aagcggaggttggaggaagccgtgattgtacc 336 2895678 SIRT5 NO aaagcagccgtggagacaaccatctt 337 2978057 -- NO ctgtgttgtctcagtcaagcctagaactgaagctacctgacatcaagccaattgtccaggaccagcatttcca- gcacttccagttgtccatatctgcacttccag gagtaaacaggca

338 3595946 RNF111 YES caaggccacttcatcatcaagcttctgcctgcccgcattctcatggaaacccccctcctcagactcagcctcc- gcctcaagtggattatgttattcctcatcctgt acatgctttccattctcaaatatcttctcatgcaacatctcatcctgtggcacccccaccaccaactcac- ttagccagtacagctgcaccaatccctcagcatctt cctcctacacaccagccaatttcgcaccatattccagc 339 3628693 HERC1 YES tataggaaatcatcaggagccaagtgtgtttatcagctgcggggacacatcactcctgttcggactgttgcct- ttagttctgatgggttggccctg 340 3734777 MRPS7 NO gtgagctactgccacgctgaaaactacctgtgggttaaggatgtagttcctttgtaagggtgggcaggcctcg- taagaaagatgtagcagcatattcactatc cgttaatccttctttctttgaggctggaacttgctctctctgcccctatttccttgtaaagagggagcac- attgacttgggaatttcctccaggaaactcagggctg tttt 341 2806269 DNAJC21 YES acagagctggatgactatggccaatttggagaaagag 342 2849121 DNAH5 YES atgaatcccaaagcgattactgccccacagatgtttggtcggctggacgttgccacaaatgactggactgatg- ggatattttctacgctttggagga 343 3012989 -- NO tcttattcttggccacgggaccaaccctcacaggggcactctatgcagaagcttccttcctaaattggaactc- ccactttgaccactctccttt 344 3184655 -- NO ttgcaaggcccacaccacgtggctgagaagtcaactactacaagtttatcacctgcagcgtccaaggcttcct- gaaaagcagtctaacagcaaaagaaaag cttatattaaataaatagttaaatattaaaccttcaaaagaaagactcgacacaatgacacaaagcacat- tctggaggtcctc 345 2428776 RSBN1 NO gctgcccaagatgttggaacaccatgtgcaataaagggcttcgtcttggattttggccttattaccacaacca- g 346 2502833 DBI YES acggcccgggatgttggacttcacgggcaaggccaagt 347 2608589 -- YES ttccattgatgaattggataatgctgag 348 2781610 -- NO cttacaggagaaatcgaaacacagctgctac 349 2810989 -- NO ttagagtttatggaccttgctcttggtta 350 2489148 -- NO cctctgccttcgctcgcgccgctctccttcagtctccccagggcctgtttcatggatagggtccccttgcccg- cgtgaaagtctcattcctc 351 3239162 -- NO ccactggctaataagcaggtctttattgagtgcccaacactgagtttagtcacaggtgcttattctggataat- taatctcagtagattaaccttcttcagaatgacc atgtatatcagacttctcttatccccaattctgggtccttattaacctcttccagggctaagtatttacc- cttccataaatcggatgttttcttaagcattttttctcctgt catcactgaaactccagcctagttcttcacttgtatgcaattttcttgtaaccctgtctctcgttttggt- tttattgtccatatgcctattgagtgcttttccagttg 352 3573019 POMT2 YES ctgataggtcttgctggctacctgagtggatatgatggtacctttttgttccagaagcctggggataaatatg- agcatcacagctacatgggaatg 353 3937196 DGCR8 YES ttgtgcccccaaaaagaggcgaacagaggaaaaatatggcggagacagcgaccatccgtccgatggagagaca- agtgtgcagccgatgatgaccaaga 354 3154331 NDRG1 NO tgctgggcgtcaagcttgcataatgccgtactttgagggcggttgtcacaagtatcacaaaatgggtggctta- aagcaacagatatttattcccttttagttctgg aagctaaaagtccgaaatcaaggtgtgggcagggccgtgctccctctgaaggtgctaggggagaatgctg- cctgcctcttccagcttctggtggctgctgg ccacacttggttcaccttagctagtagacacatcactccagtctctgcctccatcctcactcagcactct- cccgattgtatctctgcgtctatgtccaaatttccttc ttcttttaataacatcagccgttagctttagggcccgctctaatccaatatgacctcatcttaacttgat- tttacctgcaaagaccctatttccaagtatagccacag tgataggtactggggttaggacttcagtatgtctattttggggacacaattcaaccacaacctacagcaa- agggtaggtggcctgactgaggtggggtggcc gatttgatggtagatccagaaacagaactcacttaggcctgattctggagacttccacagcgtcagtcta- atgtgctgagtgccccgcctggaggaaaaattc gggcatc 355 3697772 PHLPPL YES tcccagcgaatcagtaccgtggatctctcgtgttacagcctcgaggaggttcctgagcatctcttctatagtc- aagatattacctacctcaacttgcgacacaac ttcatgcagttagaaagacccggaggcctcgatacactctacaa 356 2611934 SLC6A6 YES gctatgacctcgctggggagctacaacaagt 357 3127807 -- NO caaggaagcgagtctccgtgacacgtggtacaatatcatgcagtacacacggaaccagaaccaagaagaaatg- gctggaaaagatgaaagaaaaaaaa agttgatatagtctcaaatgtagtgaaaaaacatcaacttatagattcaaaaagttcataaacccctcat- aaaaataaatgtaaagaaaaccctacctggacaca tcatagtcatcatacagagcaaattttgtgcattcacaggtaacaaagatatgaacgacagctgactcaa- aacaatggaggctcaggatgtgtgaaatggtga aagaaagctgttgactcactattcacactcattgagaatatcctttaaaaatagtaagtgaagacgttgt- ggcaggttgaactttcc 358 3909039 SPATA2 NO agggctacatcaaccgacctttcgggtttcacggtgaagaagtactaacgcattgatctcagaggcggaggcc- tgcacttgaccatgtaggtggcagagat cgtgggctggctgtgtccacgtgggagttcacttagcgactcagatatctcaaccaatggctgctttgtt- gtctgacaagggagaaggtggcacttccgttca gattcattttgctaatctctccactccctgttcagttggttctttttttggggttttgttttgttttgtt- ttgttgttttgttttttcctttaaagaggatttctgtctctgggacc ctcgctgcacctacccctcccattgcaaagccaacttggactgggaagggcccttcaggtcaccaaacat- ccacctggagcggcgagctagaggcctgtt ggcttgtgaaatgagccctcctgccacacggggcctctcccaaaggctcatcccttggccgcccccttcc- taaacacaaggatccccagctggactcccca ccccctggcttccccacctctccaggtgtcaaaggtgaaccgagtccagtattagctgaatgtcatttcg- tacaccacagctcagtcagcccatggccttcgt gaactttgctcc 359 2412620 NRD1 NO gtttctttgaggaacgcagcctgaa 360 3220615 KIAA0368 YES gaccctaaactactgtcaatggcatattcag 361 3521230 -- NO tgctgctgacatcacgggccctgggtt 362 2327492 SNHG3 NO gacaatctttggcagacttggagcaaaagattgaggtgcatttcatgcctcctt 363 3557645 AP1G2 YES tgtcaacattcttggtcgcttcctactcaacagtgacagga 364 3709227 -- NO tgccgtcctcagtgaatcacagcagcttcaaaggactcaactggcaagatttcccacag 365 4021348 ZDHHC9 NO gagagcaagtaagctgtcccttttaactgtttttctttggtctttagtcacccagttgcacactggcattttc- ttgctgcaagcttttttaaatttctgaactcaaggca gtggcagaagatgtcagtcacctctgataactgg 366 3030989 ZNF862 NO agggcttgaccctgcctagatcctccttaccaagaaagggctgaaaagagagggcatctggcatgctttttgc- cacttctgtttctaggttatgtacttcatgga atatctgggcattgcttagaaacctgtgtcataaattggctttgggcaagaggctttgagttggaagaaa- aggtggaaagaaagtgcttgggggcggagttc agggatttgacgggattgccagcgcttccaggccgtgtcatccaagaccagtgtggttgtgggcacatta- gcttggagacagtggcagcctcttgggacta acatcttt 367 3035657 -- NO agtccggtggcttagatgacaaatggaggtagaggacgcattctcgcctgttatttcgatttttttctctcct- caccctgaccgtcacgttctcaccttttccacctc aatccccagtcacactagcttcccaggattaaaatggtctct 368 3626930 -- NO tgctttcacttaaggcagggctgttgagtcggtgaggggatgagggcatctcaaaagaaggctggctttcagg- attgcacagagatgttcctgctcccagca gactggggtaaaatttcctgggaatgagggcatttctga 369 3091396 -- NO caagtgagagtgattttgttacatgggatacattgcatagtagtaaagtctgggcttgtagtgcaaccatcac- ccgaata 370 3323928 -- NO cagtgcatcccggaaaaaagagagcaaa 371 3326853 TRIM44 YES tggccaagaggaagtgtccggaccatgggcttgatttgagtacctattgccag 372 3402333 -- NO caaagtcctttgcaagtctcacccttaagcgcgtggggactgtgt 373 3796317 -- NO tcacgttgctggctaccctcatatgtgtgatgactgttagttgtacaattacatttaagaaagaggattacat- tgctagctggaatttcttctactattataaaaatag aactgttttaccaacaagtctcttctccgagtgggacttgatggtaactataactgggatagggcaaatc- aacgtcatgggtccacaggttttgctttaa 374 4020467 -- NO tcccaacaagttgaaccttgcgttacgataaaagcagatgtggcatccaatcctaccacccagcaaagagaaa- ccccaggcattcaactgcagc 375 3180404 -- NO catcgctgtgtgcatctaactcttgattcacggtctgaccgacgccttggtttctggagaactgccctcgttt- atggaagagtcactgtcatcaggagccatccc agggagaggctcagtgggaagtgtaaaggtggagcaagtaaaccggctccagaagagaaggcgaagaagg- actatttctgtttagatttgcttaaccgca ttttcactttcttgggaacccctgatggagttcaaggtcatagaagagaagaaatcagacactgctacag- gactcttgctcttggtt 376 3781848 -- NO gaggaagtgtctggtccggtccctagagcatggcaggtatgcactcaatgct 377 3868844 KLK11 YES tcaaggcattatctcctggggccaggatccgtgtgcgatcacccgaaagcctggtgtctacacga 378 2396267 -- NO tggggacggcaacaccgcgctgcaagtcgttatcattccg 379 2862752 GFM2 YES tggtggatgtagtaatgaaagaaaa 380 3869672 -- NO ggagttgcatccttgcttgactaaaatggaagccgtattgattttgaaatgaaaagcttcatgatgtagcatc- tggactttcactgtcc 381 3876038 PLCB4 NO taaggatttcaacacacgtaaggccatgtttctgatgttatag 382 3879228 -- NO ggggagggacatgacttcctgttacgggatgaggaagtagaggttcatggagga 383 2399914 -- NO ttagacttgaaagaacctcgttcacctgccacatgctatcctagggaattaatagcttcccatgtggacactc- actctatgt 384 3142073 -- NO ggggaacgaagcctgacaactcctaagtttctggcttctacaaccatttagtgaaggtttcattaatggcagg- caggagtacagttttagaaggtctggactgg agagacatttgggggaatcatccgtgagtatcgagagttaaagacatgccaggaatagtgtatacaatta- aaatagacaggggcttgggaaatgccagttcg cagatatatatttgtcataagtgaactaaagaaaaggtatatggttggatgagcttaaacccagcatg 385 3777286 ARHGAP28 NO cgcagttcatgacttgtaccagtgaaggtagcaaggtctgtgtgttggtgatgaatttgcaggggatcaggct- gaagaaacaagacttgggagagaggatgt gagacctttttatgacatgcatagagttggcacctcagcctttgcatggtagggagctagctgaaggcta- cctccatgacagatgtacactttgaaaagacag gccgggtgcggtggctcacgtctgtaatcccagcattttgggaggctgaggtgggcaaatcacttgaagt- caggagttagagatcagcctggccaacaca gtgaaacctggtctctactaaaaaaaataaaataattagccaggcatggtggcgcacacctgtaatccca- actattcgggaggctgaggcagaagaattgct tgaacacgggaggcggaagttgcagtgagctgagatggcaccaccgcactccagcctgggcgacagatca- agactccatctcaaaataaaggaagata cagctaatctatatttctttcaccagagatcaccaccactaacaattcatactggtcgtttttccctgaa- tgttttacctatgtaggaaaattttacatcccaatttttaa tttaacactatgaaaagcatttctttttataataaagacactctattagtatacttttgatggcttcaaa- actacttttgtatagatgcaaaattaaaatatcaaattgttt cttttgtttgtttgtttttttgttttttttttgagacagagtctcactctgtcgcccaggctaaagcaca- gtggcatgatctcggctcactgcaagcttttcctcccaggt taaagtgattctcatgccgcagcctcccgagaagctgggactacaggtgtgcaccaccacccccggctaa- ttttttgtatttttacaaaacacaaagagagac ggggtttcaccatgttgggcaggctggtctcaaactcctgacctcaggtgatccgcctgcctcagcctcc- caaagtgctggg 386 3851492 -- NO ttttttacggattcagtgatctggacgggcacatactaccat 387 2712928 -- NO gtgagtaaaccatggcgtgtttgttggccaaaagccgcaagtctttgaaaaggtgaatcatcacttttccatt- ta 388 3060349 -- NO ctctggaggcttcttgtcagtactagaaactaatacttggtgaatatccttttctgcttccattaccttgtat- gaaactggttccatttatacactgagattagaagca ttcataagtgatgcggcaccacaaacacagaagatcaaactactcacagtgtggagaaccatgtctttta- taagtgtgatgtgcctaaaaccatcatc 389 3504762 ZDHHC20 YES aaaccccaaaactgtccaggcatgg 390 3543824 -- NO agtcttttataagtgttggctatcattttttctcatctatttccttgcttctggttttgcacactttaccatc- cacactgccatcagagtgatcacacctctcttcagtagc tcccatcatctactgcataaagctgagactgttagctagactgttaggcacctttcccacacgatctggc- tctgccccacttcccagcctcagcccacatggct aaacaa

391 3781951 LAMA3 YES gatttgggcttaccacctactgaccacctccaggcctcatttggatttcagacctttcaacccagtggcatat- tattagatcatcagac 392 3216926 -- NO aacactgatctccacgagcacaatcatccaaacggagatgggaacccctgttctaactctctcagaggcctga- a 393 3448246 -- NO ctctttggtatattattgcagatgttgttatttcacagttaggtaaattagacataaaaaggtcaaacgactt- gaacgtgctaccataaaaggtcagtgataaagc cagaagtcatttctcagtgtccatcataagccacc 394 2693224 OSBPL11 YES ggagatggctgggtttatcataaaccactttggaaaataattccaacaacacaaccagcagagtga 395 2672926 SMARCC1 YES tatgttcatgcggatgctcctaccaataaaacactggctgggctggtggtgcagcttcttcagttccaggaag- atgcctttgggaagcatgtcaccaacccgg cctt 396 2914136 -- NO ccatccgttcttttagctgacttgaatgactctaatgcagtgggttgcaggtttggctacttacctatgtact- ctgtaaacatccagaggcccagggatattctga gccactgtgtgtgaatggagtttggccatctgtagatttccgcagtctctccaggtgatcgcactgtgca- gcctcattgctc 397 3210858 -- NO tttgctctgaaaggcagtttctgtataggttcctccgagtgaagatcagaatgttatcagacactggctgtag- ctcagatgaca 398 3853401 AKAP8L YES acttggaactctgggacaaatagag 399 3605225 -- NO tggacccatctcagcagtgctcaaaccaatgcccaaactctcctgcttaggacacttctccactggccaccct- gaggccaccacacctcactggccactcct cctctatcttctctgctggctcttcctcctctatggccacctaaaggatgggtgttacacactcaatcct 400 2377461 -- NO tggagttggccttgttaactattaaacacaaaagcatgtgatagttacctgagagatccatgcaggggagagt- ccaggggaaggtgactgatcactgcttcc cagggggaggcagaaaatgcttcctggaggagatgatgggtggattaaggaagatgagttgagcaggagt- tgtagctaccagccagggaggaagggta ttcagagcagaggaagcaaggtgagcaaaggcaccaagatgtgacactactggactgccaagcta 401 2934549 -- NO gtgtgctactggcttatggctgatacgtaagagaatctcatctatctctaaatgttctgccttaagccgcaca- aagga 402 3185031 -- NO tggcacatgtggattctataccttaattaaagccactcccttacatacacacatttaggtatcgccagactcg- cctgatgaggaataattattctttcctccatattt cttaactcctgtcttttccatgaaacggcttggcattaaactccttcccaga 403 3560964 -- NO gtaatgtggcggtcaaaaccggcgctggaaccacgggacatgtt 404 2732616 MRPL1 YES aacgtggagccatttaccagtgttcttagtttgccatacccatttgcttccgaaatcaataaagttgctgtat- ttacagag 405 3150536 -- NO gccactcattcatggttgttctatgttccatgaactctaatagcccaacttatacatggcactccaaggggat- gcttcagccagaaagtaaagggctgaaaaag tagaacaatacaaaagccctcgtgtggtgggaactgtggcctcactcttacttgtccttccattcaaaac- agtttggcacctttccatgacgaggatctctacag gtaggtta 406 3774169 -- NO atcgctgtaccattctggggcactggagatggcagctgagaagcagagaagctggagacctgaagcctccacc- cttggctgtggctgccgagagaggcc cctgcagagggagccccaggccacacccagacaccacagccagctcacagtgcggccagagggcacaggc- tgcttggggggtgagggtccccattc ctgccacctctcacagaccatgacccacagggctgggggcttcccctgggagaaagtccttccctcccca- tggcccagccctggggaaagaaagcagag actaactcagggactgcagtaggctgaggacaagggaggtgggcttggggtgaaggccccccctcactcg- cagagaagggacactaccggcagtaga ggacagggaggcaggacgacggcagttagagacgaggcgtttcaggtgaactgtatgtagtgttactccg- gacgtgagcatggcctgggtcagtcgaat gaaatgagctgggcctcgctgccctgtgccggcggcccctgtgcctgcggttgctgggccacggggggct- gctgctgggggggaccgccagagggtg ccatctgtgcaggaggaaagcaggcatggccctggtcctcccttccccagcccagggaggaaggcttttg- tcccagcagagccacagacccacaagtgc ttgtaatccatgtccacggactgcagctcatg 407 2987860 -- NO cccgtgtttcgtgtacaacatatgatacatgtgacagttgacaagagtgcctgagtctcagagcaggaagagt- tatcctgcctccacatgcattgaagggaat atatgtcacacgttactagccaggctcagaggagaacacatctcatttacaagttcaaatctgaaaggga- gaaatgtgctagtatttagtggatcttgaggaaa ctagggatgtgttacccatctgtgcaggaacattagatctagatggggctctcctagtcaaaacgctga 408 3829652 -- NO atgtgactttacaaccctcggtgtcctcctggctgctgggccccagcctcctgactgttcagctcacacacgt- gaacctaacacctgccttggtcccctgctcc atcttctagacaactcatgctgaggaccagcccacaggaggaggcctccgagttctctcttgacgtcttc- accttgaccattttttgccaccattttagtctgtcca ggc 409 3900228 C20orf74 YES gaccaaagcctgtgtacattactaccactcgagacaatgagaacatttacagtacaaagattccatatatggc- agctcgtgttgtttttattaagtggattgtaac cttctttttggaaaaaaagtatctaactgcaacacaaaacactaaaaatggagttgatgtattgcctaaa- atc 410 2858280 -- NO ataaaatacaaactctccaacaagaccttttggccatcaggaacgcagca 411 3088555 ATP6V1B2 YES aactgcccggttcttcaaatctgac 412 3850502 LOC147727 NO gactgtttgccaatggttgtatttagtaagatttgtagactctgtttttcttttgacacagctgcaaggccaa- cagctgtgcaaagccacaagttatgctaagtcag cagttatgctatagattacatgacctgtgactgtatcattaactgcttttgttttgcttctgtaagtttg- cctataaaaaccacactcagtctttgttcaatggtcagctt ttcagatacaaatccactgagccggtgtacatctaaataaa 413 3946288 TNRC6B YES tgtggacaagcgagcgatgaatctcggggattttaatgatatcatgaggaaggatcgatctgggttccgtcca- cctaattccaaagacatgggaaccacaga tagtgggcctta 414 3430162 POLR3B YES agtctggttgaatatttagatgtgaatgaagaaaatgattgtaacattgcactgtacgaacacacaattaata 415 3751732 -- NO gaatatgcatctttacaagcatccacag 416 2347259 -- NO tggctgcctgacattattgggtgct 417 2421262 -- NO ctccctgcttggcttgatgaccttt 418 3886689 PABPC1L NO gtatggtcttgggtttctgctgagaaatggcttgtaggtggggggttaaagttcctcacacctctcctgaacg- ggaggaagctgctgttcaccagtttccagtg ctcaatgcgggcaggtggggcatctgtgcgtttggtaaatacatgatgtt 419 3951993 -- NO ttgagcccagtggcgggactccacgacgtagacctctctccttctgcc 420 3966982 -- NO ttcctgctgaccaacctaattctggtttcatacagggcagccaggtgcccacctaaaagactgcacttctcaa- cttccagttgtttctatggataatggttggaag cagaaattgggttggggcttccagataatcccccctcacagggactgcttcaagagaaagggatgccctt- tggttctttctcctttccactgcctggaatgtgat gtctgacactgtggcagccatactggcataatgaggccaactctctgccatgctaagagtggcagagctg- ggaattgaaaagagcctgctagccttgggtt gcttccccttgatcggctcattacttggaa 421 2756515 MFSD7 NO tgagcgccttgtagtccaggttgcccgccacatcgatggaggcgaactggaacatctggtccacctgcgggcg- ggggcgaaagggctccttgcgggctc cgggagcgaattacaagc 422 3261869 -- NO tttttgtattctagtcgttcagccccctcccctcccatcttccagcgcttctgaacaactcctactgttctct- tcc 423 3391839 -- NO ccctatagattgtttgaggaccctattaaatattgtatagcctctaggaataagcctttccattgacttgctg- tgataaacagatcttttgtcagcgactcttaaaata caaaacagccttgggcagtagagtaccac 424 2437406 C1orf104 NO gcttccctgacctagacagtcctgactgatggtccaacctcaatcccacttatttttggctaggccttcctgg- gagtcataaaagagatgaatccattctagagg tgcacagcctgtctcttccctcacaaatgtcagtccccaagtcattctgatccaccttcctaatattttt- gccacctccaacttctttcaagatgaaaaggaaatgt agagaagcaaggtcagggtagacacttaatcccactgactgtctttaatccactcttctccctctcaacc- tggatgatctccacactcctatccatactcagata caggatatattgttcccctattatgtgctaagcactttcatatcccttgccttgcttaatctttacagtc- ctgtgaagtaggaattttatccccagctgaggaaagag actgagcgagaccgacttgctcaaggtcacacagtttttcaccaggggtagcagtgttcacg 425 2802671 -- NO tagagttagagtcagggccctggtccctggtgctctttcctggtcgcttctcatagccaggacgcttgcttac- attagttctcaaccccactgggaccaatcatttt tattgccaatctattttggggctctgttctcgtggcaataaatcattctttcagagctccctatttaacc- ttgtgagagcgtgtgtgtgtggtggaggtgcttacata aatgcagtatttttaacctgcctggcacgctttaggttggcgtta 426 3415835 ZNF740 NO aagtagggcacgctctcagagaccaggatagagagtcagggaacctgggaaagagtagtgccagttccgggta- ggctgctgcaccaggccctaccagc tcaggctataaacagtctgctttgccccaagtttttccgtccacccccaacagccttgtcatcacttagc- tactgatcacgcccatggcttgacattggagggt tacattagtggagtccgccacagcttcgaaccctctccccagatgccctttgcctctgctgtggccctgg- ggttttatcaactg 427 3764797 -- NO tgggactgtcaatcattggctctgcctctctgaccacagactaaatatatgaccagtctaacctgttaagcat- aacaatatggacactgggagagaagcctctt gaaatcctttgctgaacggatcatgtacaagctgccaagagttcatctc 428 2431813 -- NO tgatgcacagtttaggagcaggaaagccatgtcttggatccagga 429 2468734 -- NO tgcccaagtccttgaatcctacagaccttgctaatggctccgttcacgacacccaactggtcctgaactctta- ggattaacccgtttgcttatggctgaggaa 430 2512616 -- NO cctaactaggagagtgttttcaagggagagattgctatagcatcagcctcagggtaggagaatgagcttaacc- atgagatttaggtttgagcatgtttactata agtaaaaagcattttcctggagtctggcaaatattgtggaagatgtac 431 3242348 -- NO aagagaatgggcaaagggagcgggtaggatggcggccgcaccaccagccacggactgggagaggcccttctgt- gtttccagatgagaagagagctca aggaatcccaggaatagactccatggaaaagaatgaaaaaaatcagagaaaagccaaatatccaaaagag 432 3316358 CD151 YES tgggtgagttcaacgagaagaagacaacatgtggcaccgtttgcctcaagtacctgctgtttacctacaattg- ctgcttc 433 3473828 TAOK3 NO tcccactagcgatcagctgacattcctaactgaaggctgcaatgtgttgcttattcattttgtaccgtgggag- ctgcggggactagcagagagctaaacta 434 2453074 C1orf116 YES cccggaagctgccacctaatattgttctgaagagcagccgaagcagtttccac 435 3144603 C8orf83 NO caggaatgcaagcactgctacctaactaaagaccttggctttggaaacatcttaccccttggcagctctccag- agtttagacttggcagcatcaaagac 436 3035937 GNA12 NO agcactcctcccacgggcctgggaaggcaaatgtgttttctgaactgtgttgagaccgtgtgtgtgtgtgtgt- gtgtgtgtgtgtgtgtgtgtgtgttggggtgt cttgtgaagtcctgctaacctcttgtcagcagaatattcgagaaatgc 437 3854106 C19orf42 NO cttcaaagtggagtagtggcacagagaccatatggcctgcagaatggaaaatgtcacctgtttggcctcttac- cagaaaaatttgccaaccgctcaactagg gtgtgatggagaatcccaaggtgtcccttccctcccaaagccactcagggaatcatctgtacc 438 2604179 USP40 YES ttgcaatggggagtgacgttcaacctgggacagaaatggaaatcgtagtagaagaaacaatatctgt 439 2625696 PDE12 NO tagtgggacttttaagcatctctgaaataaaaaacttctttttacagacaagcattatagtttgagttacaga- caacagtgtgtatatatgtaatatatatatagtaaa atgaaatttaaatatgaagccaaactttttaaaattagaaactacaaatggttatactgattagtgtcta- gcctagagtggtaaccatgctttactaattcagttatg aaatacattatttataatgcattagctgtattagctgttgcttttttgatgttcaggataactatgttat- ctcatttctgcatttaattaatagctcgagtattaaaagccc actcccttcaagaaaagctttgattttccccagtcatgaaagcccttgtttcaaattctttaatctctga- acctagtatcataagaatttcctattttgataacatctgta ctttcatattctgctcactatcaaatgtattgttaacacttagtaagtttgaaaatgaaggggttttatc- tgcatttgacattgaaccttgaagtactttaagtactcca aggggaaaattaaagtggaagtttcttcggatcttgttta 440 2410545 POMGNT1 YES

catgtggatgcggatgcctgaacaacgccggggccgagagtgcatcatccctgacgtttcccgatcctaccac- tttggcatcgtcggcctcaacatgaatg 441 2545098 HADHA NO atgtgtgtgcagaattctaggcagcaccttagggagggactgggatgagagaaagtgggacctggtgggctca- accacacacacctgtctgtgcagatgc tttgcccaggcttctcaccacggtgtaccgggatatta 442 2749561 ETFDH YES atgctggtgccgctagccaagctgtcc 443 2849125 DNAH5 YES ttcttcggaccttgggagcagcaaaaagagccaatccaatggatacggagtccacgattgtcatgcgtgtact- acgggacatgaatctttcta 444 3022356 -- NO gaacacctgcccaatgtcagctatacttcagctctcatttgcactattcaaacttataaagttgaagagcaac- ctacgcctgttg 445 2474026 -- NO gtggtagcagttttccagatgtggatgcttcatgatctggtg 446 3160004 -- NO tgctttgttgagggtgtaaggggaa 447 3795785 -- NO aatgggaatgaaatacatgcctttttgtttttaggggtgctcagttataaatatgaaaggctgagaaaatgct- aattgtacagtaagatcaactggacttgttttaat aagacaataatttgaaattagtaaactattttatacaaatagtgctaaaactttggaaggtcctcaacct- cctgg 448 2990169 -- NO cttgggtatcacacaagcattactgacattgagttcatggaaaatacagaaaatatatacaaaattaatgcca- cagaacatgacaaatggctgtgaggggag gacttttgatcaattgcttgatcttaaacttactttagaagaggtggccagtgcctgccaattggctgcc- atgtggatacttcttatgcttgatcttaagtgcttttgt gtgtgacagctctacacaattccctagttaagagttacttctcaccaaccaaagg 449 3858632 -- NO gctgactgcagattcaaccttctgagctcacgaa 450 2481311 KLRAQ1 YES gctgagttgcaggggaagtaccagaagctg 451 3726479 RSAD1 YES tggccctggggctacgcaccgatgtggggatcactcaccag 452 3847164 -- NO ccatgcgaagtaccaagccctagttgttctccatccaggaggccgtgtggctcatcccttacccacagaccct- cactcaccaccttcgtccctaccatccaca gcacccgctggccctgaagtgattccttggtcctggacctggggttttgcattttgtctctgaggaggag- gtcgcatggagggggaggggatggggatgtg ggtgtatggacgggtggtgggtaggggcacgtctgatccactgtcacggcacctctggtgagttgtaatg- cgttcgtgactccaactgactggtcttcaccta acctgcttatttctctgccaacacctgggatgggggtttgtaaatccagcagggctca 453 2945519 GPLD1 YES cttcccatgaccacacacaggagtggggaaaccttacttgtacttcatcggttttcttccaaatcagcgacgg- gagtaacatttttattcctatcaccaaaccac ctgaaaaatggactcctaaacttcctcatatgacatcacattaggctaatcatgtaccctcaatatcatc- agggtaagtgtatttattctgttattattacatttgtagt gcaagagctggacactctagaatcttccatgcacactactttgggagg 454 2960606 -- NO ctaaggctggatctccgtttctttccacctgctccaactgtacccacagctgtgtctgactggctgccgtcat- tatgctccagtgtgtacatctctccactgacact ggtgctctt 455 3275073 -- NO gaggaggttgactcaggagaacttggg 456 3392454 -- NO gatgctgaattgaactgggatcttcttgtctgtcaagcccttgaacagctttccctttaagcaacaaagatga- caagtttttgctattttggattagtgagagtgtac gaaatggtttccctttccttccaggcaaaaataccaacagaatctggcttcggaatgaaagtgctaattt- catttggtgactttcagatttgaaatacgggcttga acaggcattgtgcattagtcagctgaggcagtggaggttatttttacgatgctaattattatttcctgac- agtgatttactttatgttgtctactgttttacgcccccaa actagccattgttttaggaacagaattggttgggttgtcatgctcttttcaaagacaaatcttactattt- tatgcatagaaatactttcctgtaataaagaagaaagct ttattgaagagaatcttgcatatgaaatgtaatctggataaatattcaaaactaataggtttatatttta- gtcttgatttttaaagtatatttttctgacatcctaaccacc ttgctttatgtgcattaaagttaaatctgttttactgggatgcggctgaat 457 3428624 MYBPC1 YES catttgagatgcagatcatcaaggccaaagataactttgcaggaaattacagatgcgaggtcacctataagga- taagtttgacagctg 458 3869530 -- NO ccattacagcagcaggatccagtgacccgggatgctcacatctctccctgacgtgggcggagtagccccttcc- tcccaaggtcactgtcctgtccaacccc gtgctcccctagcccgttgggaggtggacagtgagacatcttccca 459 3180781 -- NO tattgggagtcctgtcagaagctgcctgctacagggtctttagctttccttagattttcaaagaggtttgtga- tccaagaagaatagagttttgaatctagattttat actaaacgatcactttagattttcaggagtgtgtgcctagtttgtgattaagtta 460 3319155 PPFIBP2 YES ccacagtgctgctagtaatgaaacctaccaggaacgcttggcacgtctagaaggggataaggagtccctcata- ttgca 461 3428631 MYBPC1 YES cttgatcctgcatatcaggttgacaaaggaggcagagtgaggtttgttgtggagctggcagatccaaagttgg- aggtgaaatggtataaaaatggtcaagaa attcgacccagtaccaa 462 3435265 LRRC43 YES agccgaaagccgtgattccgatctacgaaggcgattaccaccctgagcccctgaccgtagaggtgcagatcca- gctgaaccagtgccgctcggcggagg aggctctgcgcatgttcgccgt 463 3697431 -- NO ggaaagcggggcagacaaagtatccaaaagt 464 3928125 -- NO gggcactcacccaagtaatgtccaaacaatatttttccatgtcccccctcccccagaacacacacaggcaaag- gcagagatgtttactgtgaggtcacatgg catgaagcaaatgcagccttatctgtttattattacaacagccagttagcattggcaaatgtgctttggt- tacaaacatggtttctgctaataatttcatgaagaag cttttaggatatgtgaccatttattcttagtataatcaatcattgaaggataaaaatcagagtataaaag- tttatactctggcaaatataaatacatgcacagaagttt ctgacagtttaaatttgagcatatttgaaatattaaaggcatgaaatttaaaaatacacatacgtgaaac- tatggtgaacatgttatgggtttgtcccatggtttaac tctgctcagcccacgattcttagctgggtcagtcaatagtctatttttatcattttctaccctgttgtac- agcatgatcatatc 465 2769166 -- NO gtggggtcagagaagatattaggaaa 466 3545551 C14orf178 NO tggcgcatatcagcagacggcggtcactactgtggctcatttaaatctgtgttcagctccgggcctctttttt- caggaatccttgtttcgggacacccagtggaca 467 3899443 -- NO gacttacctggagagcgcgagaactggtgtagcttacgtggagtgagaagagatggggaacatgtgaatgagg- tcagagcggttgcaggaaacggactg ctgctgtaggccattttaaagacttttgattttcctctgaactgccgagtattttcagcagaggagtaac- atgatctcacttatttttaacgggcttactctggctgc 468 3182036 -- NO aagattgaggagaagagtagtgacaa 469 3063084 -- NO gagctgggtacagagtgcttcatgctgagcctccgggcatgcttcgtgtacactccgcacactctccacacac- acacgttacatggcagcagtcc 470 3387617 MAML2 NO gaaagcctgtgtatcgccgtgactccgggcgcgagccagtgtcagcaaagcggctaacaacagacgagaaaga- gaaaggaaaatacaagctacttttttt ttccatctataaagcggagcaaatacaggagatagaaccagattgcttattgcgagtccagaccctcaga- tccactggccggggatggaatgtacaaaagt ggacagaaaagtggctggacatgactcggtgcaatttgctggaagtttgtaagtttgaccatcgtttgta- aattactctcggaagagtttgtctctcttgatactgt attagaatagagccgggggtgaggaatagaaacgtaagcgggaaagaaaaaaatgtgttgaaggatctct- ctcagtggctagcga 471 3566496 -- NO cctaagtcacgcctctggaactttggcaagttctatagaagagtcagcagcaggtgtgggtcaaggtcccaat- tcacttcctgcagctgtaccatcccttcctc gttctgcaaattttctcta 472 3088581 -- NO tgatctcatgatctcaaaacaaaggg 473 3120740 -- NO gagcttggtttttggtcagaagccaagaaaaaagatcggagaagaaaagaaggaatgacctcaacttgctctg- cacggaggacggggacggctcagaga taaatagc 474 3399570 NCAPD3 YES cctggacgccagtgagttactctcagacacgtttgaggtcctcagctcaaaggagatcaagcttttg 475 4010188 SPIN3 NO tgtatcaaagtaatgtgtccaccggtgtgagcaccagcaactcacttcttcctcagacatctctaaagctgga- aagattttgagggacaatatggtttccttcac cccacaccaatgttatgaatgagaccagcagaccaacagcaaacacctaga 476 2638236 -- NO tcagctctgcagccctacagttaccagctaaccttg 477 3683253 -- NO tgaatgaatatggtccctggggctaaaagtaagaaaggagaaaaaaataaagcaacccccaaatttgatgaga- accctatagtccctgactgattgtttcctg gccatcatcatcatcagcttcaactttgtcaacacacccttaatatgggtgtaccttgttttacagtttg- ccgagcactttcacacccattattggatatgacacaca acccggtgagagtgctctc 478 2502720 MARCO NO ttcacttctctgctcccgaggtgtcctcgggctcatatgtgggaaggcagaggatctctgaggagttccctgg- ggacaactgagcagcctctggagagggg ccattaataaagctcaacatca 479 3378495 -- NO aaaactgccctggaggatcggcacg 480 2642712 -- NO atcattttgctcaggccacggccact 481 2798891 -- NO catttcccagtgctgtatactcctatctcccagtgctgtttgctcccatttccca 482 3428610 MYBPC1 YES agagaaggaggccggaactacaccagcaaaag 483 3691119 -- NO ggtctcgcgcgccgtcttctcgagag 484 3821139 LOC126075 YES agaccattgtgatgattcccgactcccagaagctcctgcgatgtgaacttgagtcactcaa 485 2349300 -- NO gagaattgggaatcaagaatcagccctgtttccatcttagccacaccaacttatatctttatgattttcaaag- cttttgccatgtgattctgcccccacaaaggcat cggtatttccta 486 2638933 -- NO tgcggatctccaaagcctagggatttttccgtaaaagagagtgggccgttctggttacccttttattagaagg- gtattccaccacagagagccggaggttttcc agatgtgtgtaagagagcaggtgcgcaaggcaagcaaatgagcgcaaacagtattatggaaaacatttga- gaagttagctccatgaggactgtgggctcc acaagaggactcgactgggtagcctggtctgacacaggtacgtgaaagcagagtattgcttcaaagctgg- aaaccttccataggagcctcacactgttgga agatgtactgctgctggttaaggtcaacctggggtgcaatgctgctgtcttcatcttcggtcccgaagta- atgctcaataagatcaaaggccttttggtagatct cctg 487 2661085 -- NO ttcctcacaaactggccttccatttccagcagaggcaaatcaaattgccttttccgccctcatctctttg 488 3037551 -- YES ggcagtgaggagatcggtaacttgggagt 489 3215176 -- NO tggccgtctgtacagaacccacctgcaaccaccacaccctgagcccatgtggccgtctcacctctaagtcacc- caa 490 3410744 DNM1L YES gcattacaaggagccagtcaaattattgctgaaatccgggagactcatctttggtga 491 3439960 -- NO cagagcgccagcaagcggccacagaa 492 3461262 -- NO tcattttaactctgtgcagagtatcaaatccatccatt 493 2316284 -- NO atgccaacgccgacgtccctgcgggg 494 3882865 -- NO tcctagcagcacacatatgcagctctt 495 3685651 -- NO aggggagcttcgtgatcctgtgcaccaagtctccatgccccttgttgtacccagagcaccatgctccccgcca- gccccctgtccacccctgcttagttataca gccattgtccgttttgtgtagaacagtggctttcaagcttttgtcaccatgatccatattttaaattgca- accctgttccctatgatacct 496 2854135 -- NO ccgaggactgttgaattgtggaacatctggtggaaaatagcaagaggtgacagaaatgctaatggggcagtga- gatgtagacttcaggcagaattgttgtac ctgtcgagttggag 497 3314277 -- NO gtctaaggaaaacaacaggctgcgcgaaatcagccctcagggtaacactgaacctggcgctcttccggcacca- cacaggaggcgacgcccgggaaag aagactgagcggctcctgtctgaagacgtctccatcagtccagcca 498 3724236 NSF YES tgatggcgtggagcagctaaacaacatcct 499 3746906 NCOR1 YES cacaggtatgaaacacctagcgatgctattgaggtgataagtcctgccagctcacctgcgccaccccaggaga- aactgcagacctatcagccagaggttgt

taaggcaaatcaagcggaaa 500 3909730 ATP9A YES gaccacttcagattcgatcgtatgtgtacgcagaagagccaaatattgacattcacaacttc 501 3428460 UTP20 YES ttggttgtacagttggcacgagatctgcagatggatttctacccacactttccagagttttttttgactatca- cctcgatcctggagactcaggacacagagttgtt agaatgggctttcacctcgttatcatatc 502 2751975 GALNT7 YES gggattatttgccattgaacgagagttcttctttgaattgggtctctatgatccaggtctccagatttggggt- g 503 3894100 C20orf96 NO tcccagcacctggagccttggatcatttacttccaggaccggatctccattcagaccctgatctacagtctcc- ctgctccctctgcccttcctccctctttctttcc ctccctccctccctcccttcttccccccttcccttccctcctccttccttcctcctctccctccctccct- cctttctttcttcctgtggttttttcctctcttcttcccttcttt ctggttggtgctgctgggccaggtgggaatttctgatta 504 3908236 -- NO accttcagggtgctttcacaaatgagctactggagtatttttcgtatctttggttgatgaaaaggctcatctc- caaacttaatggttgtaccaaggtgttttcattcct tcaacaagtcactgagtgctttcttggaacacacagccttgcactgggggttatggggagggaggaagag- gctggacagggttactgcatactgccggaa ggagattctcatttggctgcagagtgtcgcaca 505 2407923 -- NO gaggtctcccgtcactgggcatccagctgggtgctacggccgtggctcctgccttctgcagccctgtcagggc- ccaaggccttcctcatcagcacttgctcc agcctactcactggagttgtgttctgggtgggtgtgtagaatactcgcactcctacttggggcatcaggg- agctctctagcaatttc 506 2571603 -- NO ttggaagctaacctgccacattgacttaactgagtgaccccagttccaaggcagggcctctacaatttccagt- ttatctattgtttcctgtgtaagagcagatact tactgtaagtccgtaagtgctactcgtaggtcaaacaaccttgatgatatcacacttcaattgtcttata- aatcccatctgaaccactcctaccctatggtatatga gccctgggtttgggtgctaatgcggggatccaccatctcatctcattgccgcctgagacacctacatggc- tt 507 3634205 -- NO agcagatgtcagcatccgggtcacctag 508 3746967 NCOR1 YES ccactgtataaccagccatcagataccaaggtgtaccatgagaacatcaagac 509 3675286 WDR24 NO ccgcctggtcttgtgcccgagacgggcggaggctggaacttgagacctcaataaaggaagtagag 510 3809651 FECH YES agctggcaccattcatcgccaaacgccgaacccccaagattcaagagcagtaccgcaggattggaggcggatc- ccccatcaagatatgg 511 2793478 AADAT YES catattgagcagaggaccaaaatcgatgatctccttggctggtggcttaccaaatcca 512 3139792 -- NO tgtgtcacttctgcattgcccagtattttgagttgggggaaaaatgaactcacctggccccacctcctgttcc- agtgtgaaatactgacacttgctgccagccca gcctcctcacataagcattagaaatatcagacagtccactaggttagagcacctcattcatgaggttctg- ttatttattcggctctcccactaaaatgcagggcat aaatttatgtgtctgctctaagactgcagctgtctgccccccctccaccctcctcctgcccttcctgtgt- cagtgttacattcgctccccccacttttggtctcaggt ctgtctcctttttgtttttatgggtgatttgcagtgattcagacagggcatccttgcatgttggcacttc- ctggaggttaccaggaggcagccatccttccttggctt ggccaggcatccccgactccaccccactttccccttggtggtggaaaggtgggttggaggtgtgtactgg- ggcacatagcccaggaatgttgctctgagaa gaggacatgtgcagtagacacaaaaatataaggaagcaattatgttcatcaagccgaaagttgcagattt- tgaggaaatgtgtttagataccactacataata aaagggaaaaccacttggcatttaaataacttacttcaagaggaaattatgatattttcagtctacaaat- agagtggtttttaagccaaccttgagtaggtacaag caaattataaacagtctgctcaaatgattttactatacttagactagaaaatggctcctcttctctctcc- ctctggtccctatgtcccagtgctgtccctcatatgtta caa 513 3296171 -- NO acatggctctggtcgaaatgtgactgaagctttgcat 514 3470058 PRDM4 YES cttatttagctgacagaccacctcc 515 2830812 -- NO tgggtaacagaacgcaactttgtctccaaaaaataaataaataaattgttacaatgaaagtggctctgtgtta- gccgggagtgg 516 3151504 -- NO cttagggaatctgtttcggtggctcagagaaggatctgttgccaatcagccgatgccaggtctccggtgct 517 2978822 -- NO ggcaggtccaggaactgggtctggagccttgaaagcagaag 518 3432174 -- NO gtgcgatggaaaaggtatccaaagtgatactccctttgactctgagcatcagttgcccgtgtttcagtcactt- caa 519 3922854 PDE9A YES gaccaactgcccctgtaagtacagttttttggataaccacaagaagttgactcctcgacgcgatgttcccact- taccc 520 3225896 -- NO ctggatctgccacctcttctttcggctgtggatggccctgggagacacgcctggcctcagatgccccttgacc- caactggaggaagggtggggggcccag cagaaaagcctgcagcctccctgggcaccgtttcaaagctgatgctgctctccctgctctgggtctcagc- tcctcccctcttctgcattgttgaccaacagcct gggtctgacgcggaagcagaagaattcc 521 3981141 OGT YES aatcacgcagtggtgcacggcaacctggcttgtgtatactatgagcaaggcctgatagatctggcaatagaca- cctacaggcgggctatcgaactaca 522 3040366 TWIST1 NO cctctgcattctgatagaagtctgaacagttgtttgtgttttttttttttttttttttgacgaagaatgtttt- tatttttatttttttcatgcatgcattctcaagaggtcgtgcc aatcagccactgaaaggaaaggcatcactatggactttctctattttaaaatggtaacaatcagaggaac- tataagaacacctttagaaataaaaatactggga tcaaactggcctgcaaaaccatagtcagttaattctttttttcatccttcctctgaggggaaaaacaaaa- aaaaacttaaaatacaaaaaacaacattctatttattt attgaggacccatggtaaaatgcaaatagatccggtgtctaaatgcattcata 523 3847114 PTPRS YES gagtaccagttctgttaccaggcggcactggag 524 3903914 -- YES aattccagagaagggtttgagtttggagttttatctgttgtaaaatggccctgcttttag 525 2545695 GTF3C2 YES attcattatattgacgctggttaccttggtttcaaggcctacttcactgctcc 526 2468742 -- NO ggaggttcgttcataacacaccctagaaaccatgaaaaacatggagagccaagtggagtgagtgacccgagtt- tacaaagcctgcaatgatcattcttttatt acctgacaggatttagggtaactagaaaaacaaatacaacttatcttaggcaatcacttctctatgatct- cagggaggctata 527 3332623 TMEM109 NO ctgtctggggttggctctcttaaccctttctctgctcccagcctgcctcaccagggaaggttggaggggcctc- cctctggcttctgcatctgcgccagcaaac atcactgccgttggtctctcatgacttaactggcttccctctgctgctgccttggcttcctcctaatgct- cgtgctctcctgtccttctgaagttgctccttggccaa atctccagct 528 3457669 -- NO ggctttatcggatagggacagacgaggtaaggaaggttgtttaatgagaggccttgcttgccagcctaagctt- ttaaatttgatgccagtggcaacaataaag tgta 529 3575429 EML5 YES gtggcagagatggttgtattcgtctttgggattta 530 3676065 -- NO atgggggacgaatgccggctggattcaag 531 3541353 PLEKHH1 NO gggccctgcccagataaaattgttggtcttgtctgtaattagtattccaaaggttcaggtggtgttgcatctc- cgtatcaatgttcagctagtaggtaaagggaca tatttggagggaactaactctggcctagctactattatgctcttcactttttcttttttattctctcaag- ccccagcatcatgcagtcctcagttgggtgcttacgtgct cttctcttccttgcagcagtcctcaaggcagggcagattcctctttaaggtgctcgcatgttacccctgg- gttctgctgacccaacattagctacaaagtgggac agtcccacagtgctccctcttccttgttgtggggaagaccgcaaaaagacctcttttgctttagtgactt- tgttcctactcaatacaggaagtgttgaccagcaaa aataataattacaaaggctaagttctgatttattgttcctgactcccgtgtgattaactggaaaccctg 532 2428388 -- NO tggagctctccaaattaagaatgggtagtgacaaactttgaacaggtaacaaacaataaattcaaagtatatt- taggattaaacagtcaatttctaaatgggagt ctatcatgtctcccctttgcaatactggccttcccaacaggaattctatacttgtccagtccaccataat- gggta 533 2883068 -- NO tttctatctcttcaccttacacacac 534 3686201 GTF3C1 YES agggctcgattccagcttctacggacacctcaagcgcaactggatctggaccagctacatcatcaaccaggcc- aaaa 535 2933137 -- NO atgagcaaggctggtatctggagttttgataaagt 536 3098268 -- NO agcctcagattctaccgaggcaggcgccccaaataccctccggacgctggcagcagttgcgtgcttcatctgt- cct 537 3804158 -- NO cagtgtgccattgtaatttattggtggagtgctatcattggtaacaatatcatataaatgtatttaacccctc- ctagcttttgaagtaagattcatgttagagctagaa tttgtctgggtgc 538 3570485 -- NO tggaggggcaggattacacactgaatcattggca 539 3666058 -- NO ctcttggcttcaagtgattgatcctcccacctcagcctcccaaaatgctggaattacagacgtgagccactgt- gcccagccagctcatcttcgaataataacag ttttacttcttccttcttaatttttatactttttcccccctttttcttgcttcattgtattgactaggat- ttctgatacattgttgattagaggtggtgatggaggacatccttg tctttttcccaaactcagggcaaaaaaggattcatagttgtgccattaagtaatttgctagggtttg 540 3692317 -- NO acaatgtggctgtgtttgatcccgcgacgtgtcacttggaatctcaatttattgccaatagacgacgttgtca- ggcactaattttctggtggcgctccatc 541 3749798 MGC33894 NO tcgggggtcacaagccaaagccacaccgctagaagggctcaggacccagcccagctcccgtcctcttggtggc- atcaagcttgtgtgatatgaggtcttat gtc 542 3965785 MAPK11 NO atggagctgatccagtaacctcggagacgggaccctgcccagagctgagttgggggtgtggctctgccctgga- aagggggtgacctcttgcctcgaggg gcccagggaagcctgggtgtcaagtgcctgcaccaggggtgcacaata 543 4051547 LOC100129722 NO tgaccttggcccagaatccaccagggcagggcctgtgaacagggccaacttggggccctcctccgccctctct- ggatgcctccccttcagcactgggcct gccaggcagacagatggacacgtgcttgaggaaacacgggttttatctgggcgaggggttcacgcctgtg- ctccggggcccctgcccaggttgtgccgg gttcagagttgactggctgccagtggaacagagtgtactttgctaatgaagcccttgtcattggacagat- aggctcctccaggtcctccctgccctgtaataaa cgttgccaccg 544 2849256 -- NO aagacaggctggtgctttcaaaatcagtattttattgtgaggtcaagcagaaatgtactagcagcacaaccac- agatgacacttgtttggcttaaaacaagaca caca 545 3166772 -- NO tttcttgtctcttgagtggcggatcatgcgacacctcccgaccacagcatttgggcgagatatagacatgcct- ctaaa 546 3886907 PIGT YES acaacgagacattagaggtgcacccacccccgaccactacatatcaggacgtcatcctaggcactcggaagac- ctatgccatctatgacttgcttgacaccg 547 2474079 -- NO agggcacagagagttcaacaaacactgaaacttaagtttgtcctggacatcttcagcatccgactttctggtg- gaaag 548 2661946 -- NO gccatcttcctatcctggtcctgat 549 2963039 -- NO ttggtctctatctgggcacagtctctttggtactgtgtgttaggactagatgtttttaacatgaatgaaaacg- tggactcaaaagaaacacttttcaggtgtctataa atcttcttattttcaagtttacttagtatttggtcctggggtgtctacatgtcactcagttttgaggaaa- aaatgagatgaccttagaaataacatagaaattaatgtg attgatgaatatccttagaaatttaatgagatttatacttggaatatggcaattacaatattttattgaa- aaatgaataggtcaccagcctggcc 550 2991676 TWIST1 NO tgaatgcatttagacaccggatctatttgcattttaccatgggtcctcaataaataaatagaatgttgttttt- tgtattttaagtttttttttgtttttcccctcagaggaag gatgaaaaaaagaattaactgactatggttttgcaggccagtttgatcccagtatttttatttctaaagg- tgttcttatagttcctctgattgttaccattttaaaatag agaaagtccatagtgatgcctttcctttcagtggctgattggcacgacctcttgaga 551 3535849 -- NO ctgaatgctacaacctcggagagagaataggggagtgttggtgtttgtggtgaatcggaaagcacgtgtttaa- agaggacaatcacattaattcagttccagc tatgagattacattgtcaaatcatctgatttttcaagagaaatcacaaatttgaatttcttaaaatgaga-

aatctactttttaaataatgacgggattttcaagtatgtta aaaatactgtaggctaataccgaataagctaagcaaaacttttgtggatcaaaccgaaaccatgggctat- tttcttctcctcctcttcctcctccttctcataggaa taaaacaactaaatataatcctgtctttataatttccatataccaagctttaattatatttaatacccat- caaagttagttaaaatgaactctgagtaatttataccttat ggaaaaattacggtgttctaagtctgaccaaatgtgtagaaagtacc 552 2488753 CCT7 YES agccagctatggtgcggatcaatgcgctgacagcagcctctgaggctgcgtgcctgatcgtgtctgtagatga- aaccatcaagaacccccgctcgactgtg gatgctcccacag 553 2575232 SAP130 YES gtgatgtccagttctaaagtaaccacagtcctgaggccgacctcacagctgccaaatgctgctactgctcagc- cagcagtacagcacatcattcaccaac 554 3076375 BRAF YES cacgccaagtcaatcatccacagagac 555 3187656 CEP110 YES aatttgcagcagatatcccagcagcagaaaggggaaatagagtggcagaagcagctccttgagagggataaac- gagaaatagaacgaatgactgctgag tcccgagctttacaatcgtgtgttga 556 3286398 ZNF32 YES actgaagcccaccacaaatatgaccactct 557 3840338 ZNF808 NO acagatgtcggccactttcgccatcctgttttttgt 558 4019888 -- NO ggaacagagtgtgccagaaccctcagggtgtttctcagctcttgtttacgggccaccag 559 3831504 -- NO tggtttgcgaatatgctcaagtctctggatgaattgtatgacagtgaaggggtatgtgattagactgttgtgg- ctttgaggttgatgtgtatgttttaaaggattatg attgagttggagatca 560 2540638 -- NO ctccttctatcccaatcggacagtgatatgaccctggggatgttccatgaatcatttgttcctctttggcccc- atctgattgtgtacttatctccttacacagtccttc tgaccttgaaatgatccagaaaagatgtaaaagagtaaattctatagtcagtttaaaaggcagcaggaaa- ggattgggaagcattttggacaaggggtctag gagacaggcccagctctgcacttttccgtgggacaaaggcctttgcattctctcctgta 561 3229612 UBAC1 YES acgaggatgagcgtgtggacgaggctgccctgcggcagctcacggagatgggctttccggagaacagagc 562 3839570 KLK2 YES ctcatccagtctcggattgtgggaggctgggagtgtgagaagcattcccaaccctggcaggtggctgtgtaca- gtcatggatgggcacactgtgggggtgt cctggtgcacccccagtgggtgctcacagctgcccattgcctaaagaa 563 2380069 KCTD3 YES ggcagcaagtgtttacgagcccatatttggattggactatcgaacgagtagctttaaatgcaaaggtggttgg- agggccacatggagacaaagacaaaatg gttgctgttgcctcagagagtagcatcatcttg 564 3428646 MYBPC1 YES tctgattgacaagacgaagttcaccatcacaggtctgccaac 565 2998434 RALA NO agtaactgtccgctagaagtctgtccaaatttaaaatgtgtgccatattctggttcttgaaaataagattcca- gagctctttgatcgcttttaataaactgcaagttc attttaaatgaagggccagcatatatacttgcaagataattttcagctgcaaggattcagcaccagttat- gtttgaatgaaccctccttttctctgagattctggtcc ctggaaatccctttctgctagtggtgagcatgtaagtgttaagtttttaatctgggagcagggcatagga- agaaaatgtcagtagtgctaatgcattttgcacta gaacgcttcgggaaaatattcatgcttgccatctgttcatttctaaatttatattcataaagttacagtt- tgatacaggaattattaggagtaattcttttctgtttctgtt tataatgaagaacactgtagctacattttcagaagttaacatcaagccatcaaacctgggtatagtgcag- aaaacgtggcacacactgaccacacattaggct gtgtcaccattgtgtggtgtacctgctggaagaattctagcatgctacttggggacataatttcagtggg- aaatatgccactgaccgattttttttttttcctctttgc agtggggctaggacagttgattcaacaaagtatttttttcttttttctcagtcctaatttgaacaggtca- aagatgtgttcaggcattccaggtaacaggtgtgtatg taaagttaaaaataggctttttaggaactcactctttagatatttacatccagcttctcatgttaaatat- ttgtccttaaagggtttgagatgtacatctttcatttcgtat ttctcataggctatgccatgtgcggaattcaagttacc 566 3544955 -- NO gctttctcctcttccgggtcttggactg 567 2981913 EZR NO cagctaagatgccatgtgcaggtggattccatgccgcagacatgaaat 568 3013230 CASD1 NO agactgtctgcacctgtattcattgtggaacttcctctttcattggaaactttcttactcaagaatgacggca- gtattgttttcttatatgtgcaatgaagtggaatga taaacagtatgcctttaatttatatgtgttcttgttctgatgttgtttcctgaaatgatttttcttccta- actgtggttttcgggtatgcaagcctaaatctttgtacactttg tctcacagaatagttctgaggctccatgacagggttttgtcattgttgatgttattgttgcttcgtttta- taaaaaagccaaaattttttttccaatccaaacgttcacct gtttcctttcctcaagctataccagtgtaataccagttaccctgtggatccatttaa 569 3739279 -- NO gtggcagtatctgtgacgatgggaagt 570 2409084 -- NO agattttttgccactgccttgaggatccctgattcctattgattttacctgcccttggacctgtccacctcta- tcttcacctccacctccctgatccggtctctaatca actctcacctggacaacagaaatggcagcccaaattgtctcccacat 571 2848243 -- NO tccacaggactagctggcagatctaacgttggggagagagacaaaggtggggtcacaggcagccccagcgtgt- tggcccaagttactggaagtttggag ttgccttgggaagtggaagcttgtgtctagcaccttagaccaccgggccatcctgccacacgcttggagt- tgctttgaactatgctggggaaggtgcaggcg gagctggctgggaaagtcagcatgggcatgtgaagtttgggtgtacatgacatcaggctggcagtggtgg- gtgagaaggagtctggggttcgggccaga gggtgggctggagatgtaggtttgttgggcatccgcacagatggagcctgggagtagctgagactccatg- gggagcacgaggatgagctgttgaaggca tgagctctggaccctggcattagaggtctaggaaattaggggcaaccagtaggacttgagaggggagcct- ggggaggaggaagtgccaggagtgagtt acactggcggcccagtgaaaccggggttcctggggggcgggatgtgtgtgtgtggcagggctgggttatc- ttatacctttcagaactatgtttaaagttttgta gatgtaattagaataggatgagttcatgccactttgaaacctataattgtatgaataattttgaattcat- tacgcagacatgacacatcacggcttctctttgcgtat gatatca 572 3775781 -- NO tgactgagctgtggaccgcaagcagtggcagccccttggctgctcgctattttgagtctggagagattgttca- cgaggagcacaggctgtttggcaacatca gagct 573 3990538 -- NO ctgggtagtctacgagaaatgtcaattattatctctactacaactacttacatatatctaatgggaaaagagt- ggggcttaggtgtcagagtggatgggagaca aaggagaagctacactaataaatacaacaagtggaaggtacctgtcccattcctaaaaggatttgtgggc- aatgctggcacttggtggccaggagaatcttc tgaccccactctccctcctcttcagtcctgaagaccccaagaacccagttaggatcccctggccagaggt- ctctgtgactgcctctggactcagcacgtgca gcagcttgggaggatttgagccagtctcaaaaacttttagccccagaatgagaccagtgaccccaagcag- gagggctgggatctggagggaagagagg gggtccaaggggaccctgtggctgaggccatggagaaccagtgccagggcccaagagacccatttttcca- gttatcagaggtgactgacatcttctgcca ctgccttgagttcagaaatttaaaaaagcttgcagcaagaaaatgccagtgtgcaactgggtgactaaag- acca 574 2411004 KIAA0494 NO ggactgacgcgttcccactttcttactctgcacctccccactctcttcccattcaagaacgagtttctcttcc- ctctccattggaaatcttgctccggaggtccgaa acacgtattttaagcgtgcccttcctcacctcctggagcacccttagaagtattgcctacttatccgggc- tgagaatccttcatttttgacctggcttttttttcgccc tttgggagataaaggtccctctccaccctctactaacactctgcacccaaggccttatcctttggggtca- ccag 575 2642748 -- NO acaggggcgcatttgcctcacaaggaacatttggcaatgtcgggagatattctgggttatacaagtgggagat- taggaatgctactggcatctagtgggcag aggccaggatactgtgaaacatcctataatgcacaggagagctccctacaacaaacaatt 576 2661956 -- NO atggacacccactttccatgcttag 577 3307945 -- NO aaaatccagtcccaactgcagatccctatgcactcccccaac 578 3789999 -- NO ctctcttcttgtggtaggtcccagaaacttctacttgggggtacatgaggcccagctgggattgggcacagaa- ggtcatggctctgcacctgaccctcacctt aggggtcaggagagagccaaggacacgagtgatgggttagggaggactcaggcaccatggaatactgtgg- ccatccttccatagaggagaggtacagg tg 579 3963093 EFCAB6 YES atggcgattataccagactggcttaggtcgcatcctcacacacgaaaatttacacattcaagaccccattctt- caccgtgtagagtatattca 580 3589632 EIF2AK4 YES cagagaagctgacgaggagagaagt 581 3816037 -- NO tttccatcacccagcaaacgccgtcccgcagcacccgggaagctgcggagtcgggctggggccgccgcgttgc- gcacatcggtccttg 582 3417925 LRP1 YES cggtgaattcctcttgccgagcacaagatgagtttgagtgtgccaatggcgagtgcatcaacttcagcctgac- ctgcgacggcgtcccccactgcaaggac aagtccgatgagaagccatc 583 3696235 RBM35B YES acccgctgatgactacaccagtctgatgcctgttggtgacccacctcgcactgtgttacaagcccccaagga 584 3462998 OSBPL8 YES aagaagcttatccaacgccaaccaaagatttgcatcagccatctcttagtccagcaagtcct 585 3962740 TTLL1 YES ctttgaatgctatggctacgacatcatcatcgacgacaagctgaagccctg 586 2681997 -- NO cccagagcgagacgactattccatggccctgagcagacaatttctcttttaaaaatggtggccctttaatgat- gttattatgaggtttttaaatgacatatcaaaa gttgtttatatcacaaaaacccaacagtcatttaattatactaatgaaggtctttatacgtgtcagattt- tttaaaaaagacttctaatggccatgagaaatggactg ttgctgctgcttgcatcacagcagtggtggcagcattctttgtagaggaagaacatattttataatgtat- aagggaatttgcatttcgcttttcacggcaaacctttc tgtgttttttgtaaatctaacaattgcaacaacatggaatatttagttgggagatgtttggagtaagtgt- tgaaagcaactatgtttgcttgcttttttttttttatggtta gagaacaactgtggcgactttcacagattgaactagtacagttcaaaggaaaatcatcgactttagcaca- tctgatagctatataggcatggcagaggtgtctt gaaaaaac 587 2743344 PHF17 YES ggtcctagaggaatttgagcagcgatgctacgacaatatgaatcatgccatagagactgaggaaggcctgggg- atcgaatatgatgaagatgttgtctgtga tgtctgccagtctcctgatggtgaggacggcaatga 588 2992873 -- NO ttcccaagcactgtacggggtattgggaaggtaagaacaaaaaagatgtagtccttgcccttacaggtctagt- tgaggaaagaaagggggattgttttccagt tgcactgaatatgaatcagaatgaggaagaaagtacttggaagcctctagctgactctggtaccattcca- cggggccatgatacctttcttagtc 589 3568027 -- NO acatattttatgctatgccctgggggtaaagggtgactaagacgtgtaaggcacttgcattctacaggccatt- gcttttcatgggtataggttttctctccccagtt agactgtaagccttgttt 590 3830188 FXYD3 NO ctggagacttcctatgtgtgcattggggtggggcttggggcaccatgagaaggttggcgtgccctggaggctg- acacagaggctggcactgagcctgctt gttgggaaaagcccacaggcctgttcccttgtggcttgggacatggcacaggcccgccctctgcctcctc- agccatgggaacctcatatgcaatttgggattt actagtagccaaaaggaatgaaagagagctctaaccagatggaacactggaacattccagtggaccctgg- accattccaggaaaactgggacataggatc gtcccgctatgatggaagtgttcagacagtttataatagtaagcccctgtgaccctctcacttaccccga- gacctcactttattacaagatctttccaaataccca aatgtccctgcaagcccgttaaata 591 4011203 OPHN1 NO tcccaggctcctatgcaagttttttttccccattatatcacacttatctagcaagggaccttgtggtttgtgg- ctttagtggccatcatttctgggggttggcttttac ccttttttcttgaatatttgccaccaagtgaaaaatgttaggacataaacccttgccaggtccctttcat- ttgctatctctattattggaaaggacctaaaaattggtgt aatggggcagaaatctgaggaatggacatttctaattcctgtttgttgaagggaagttgctggaaagagc- atcagtacttgtttctatgcagatgcctgggccg tagcttgtctgtagcgtctgtataattataatgttgcccagtgtgagggaaagagctttcctacttgcac- tcttctaccaaggccctgttagtgcactgattatagta ctgacagataaacctagataaagagatagagagtgagtacatgcacactcatgtgcaaacccactcagag- atgcatttggaacagtgctactgaaaggcag tagtcattttcaagactgaattccaaacatggtttattggtgagttaggaacatgtaaggccaagtacac- tgagagcctttttgaaagtaattgagtggaaacttg atgccattctaaatcaaggcatatccaggtggcccggttgaactcactccactgtacccagtctcaaagg- ccaggttgctaagaaaccaggagtaaaagagt caagtgaccatcatttcacctgctgcttgcccccaatagtagtctctgtgaggccttactgacctcacct- aggaagtgatttttgagcccttgtttcagggctgtg gcctccctgctctatcctgaataaagcagacaggtgtgcagattttggccatgaaagcatggctaatagg- gccacagtccctttaaagaaacatggtttgact ctggttttcttgggggaaaataccacaatcaccgatgcaaacattggaagattattgagagccctagaaa- gctgct 592 3349796 -- NO tgcagaaaaggtggataacccaactctggtggg 593 3040457 TWISTNB NO tgcctcagccattctagttttgttgtgtgttggaggacagtctaatgaagacaggataaatgtgattctgact- agtgggaaatttcagattactttttaatgattgga atgggctataagatattgtgctgaagagaaaacagttgttctgttcactgctttcattgagaaaatgtgg- aatgtctcttgactaattgacaaagtgtaatgaaatg acaagctggttgaagctggtaatcaatgcatggccatatttattcattttccacacacttgaccatctac- tttgtataacacattctgctaaggcccagggataca atggcaaacaagatagatgtagttccttcccttgtggcatgtcataagagaaacagatgtgcatatacac-

acaataaataagaaaattaataattgtattaagtg gtatgaaaaaaagggggaggattgttcactcactgttacctgtgttagtatctgcaaatgcatgaatggt- tgaactcccatgtcagcatttttgttgccatttattta gtaccagacatagtgctggtctcacagcttaatatttggtaatgaataaattctgctagtggtatatgtt- gatctgaacttacaatgatgggatatagaattggcag agtggcagatgttcacaattgtctacaagtagatgtgctagacaatggaaggatgcaggccaacctcttt- gattacaattgagattcatgtgactattgagccct ggaaatgtagcttgtcca 594 3895503 -- NO gtggcggaccgtagaagagcaagccca 595 3907654 NCOA5 NO ccaggcccagctagccaagtttggaatggcatttgtcatgtcagtagccaccacctttgttcattgtgaacct- accaaggctttccagcttcatacacattgacc agagctcaagctcctgcctgcaactcctgcctagagttgaagaaaagcaaactggccttggcaggcacag- tgtcatcataccctcaccccatatgtttgggg tctgcttgaggattcataaatcagccactctggattgttgaggaatggccatggcagccacagaaaaaag- aatttttctctctgagccaaggttgttttttgtttttt tctcttttcttttttgttttcatttcattggaagatctccaatggactgaacagctccagtcagcagcag- ttaccacaaactgtgaatctgggccccaccactcttcc ctgttaaccagttctgtcagcatccccctctccagcagcacttccatgaagttggttctgagactctggc- cgtgaacacccgtttcttcagtgatttgttttgggct tttggctcaaaaccccaggctcttgtttttgtctagactcttattctgtttcctgagcagcaggaggtag- ggaccactttgatgtcagacttctggtagctggacat gttctcgagatgggtggctgttcgcgacttttgtaccagagtgaaattgttagaaggagggtttctggct- gtggttctaaatggagccccaggaagctgccctc tccccagggtttgtgctcagtagagcc 596 3679982 -- NO aagagacacttttccctaagcaggaagttaataattaagttaaccaagaaatagaagtgcatgagtattgttt- ggaaatatggagaagggaagaagagtaga aacagctgaaaagattaaaagtgattgctttggcgaggt 597 2858366 -- NO agctacacaggaaataacaccaccaaaaataacacattcaaactcagagggcaatcttccctaa 598 3048215 MRPS24 YES accatgccgcagagcgaacggtggaggatgttttccttcgcaagttcatgtggggtaccttcccaggctgcct- ggctgaccagctggttttaaagcgccggg gtaaccagttggagatctgtgccgtggtcctgaggcagttgtctccacac 599 3168775 -- NO atctgtagccgtagtaaattttggaagggcaaatcaatatggcgggtagaggctagttggtgaagcttattaa- cacagattcttttccaggctaaagttgtcttca gtggttaacctttgtttctcctagtagagaggtgggcaggataccttttgtctttgcaaatctatgtctt- gatttaggcaagtggaaggcagagaggtttcttgcat ctgctccttcaaaactaccttcagta 600 3643388 -- NO ggaggtattactgagcgccacctggctg 601 2927513 TNFAIP3 YES gtgacggcaattgcctcatgcatgccacttctcagtacatgtggggcgttcaggacacagacttggtactgag- gaaggcgctgttcagcacgctcaaggaa acagacacacgcaactttaaattccgctggcaactggagtctctcaaatctc 602 3911005 -- NO atgcctgagggcatcgaccagaacgaaccagacacgagtccctgccctctggaagctcacgttccagcagagg- agagg 603 3942797 INPP5J YES ttcatcctgggctactatagtcacaaccacagcatcctcatcggcatcactgaaccctt 604 2802457 -- NO ggcctatggtaggattgtaggcataagtgctggatcaggagtcatccctcttctacctctgctgccttctgat- gtttcttttgccaaccagcacgccggaccagc ccttcttgttttctcttttggttctaggtcacaactctttctc 605 2874851 RAPGEF6 YES caacacctgagcgtctcataatgcatttaatagaagaacattccatcgtggatccaacttatatagaagattt- tctattaacttacag 606 3147604 AZIN1 YES gaaattggctttacgatgaacatgttagacattggtggaggattcacgggaactgaatttca 607 3822303 CCDC130 YES tgccatataacatctggtgcgatggctgcaagaaccacatcggcatgg 608 2767313 -- NO ctgtctttggattgatggctcagagaagatggcagcatagatctttaaagcagtttgagtggggaattcttgg- atcttggggtacttggccatgtggacaggatt ggctggagaaggagggtcaggtggcggtcctgctgccaaggtctgagggtaatactgctcctaag 609 3159245 -- NO tgtgtgtctcaaacttcaagaagtctctaggataacccaaaggcaacaagggagaccaaaacaaggacgctgg- agacattttagcctctgatactgacagct gcagcaaacagaaaacgcagcctaaccgcgggccagataaaaacctcaca 610 3403122 PTPN6 YES gaagcagcggtcagcagacaaggaga 611 3849599 -- NO tgggcacccgttatcctagttactcgggcggctgaggcaggacaattgcttacccagaggccg 612 3534950 KLHDC2 YES tgcctatgatcaccttgcatggacagcaatcctgtaaacatcacagagtggcatcatttgtataattatatgc- attgttgtagtttgcacctgttggttttaatgtgca tgtgaatggcctagagaacc 613 3631427 -- NO ccctgttttgatatcctggttgtgaaatgtcttatgttttctgctaatctatttgtgttaaagtaagcagggt- tggtttacagtaccgtggctcaaaagctagtgtagg cagctttcctctcctg 614 3779594 -- NO acgccaagagtccagtgcaacgatccctgccacacggtcagccgaccccacttggtgccacagggtccagcct- cggccactctgggctcaacctttccag cacgtctgggagcccaatgaggctatgggacagtgtgcatttccctcaaggcctccggaaagtcacctgc- cacccactgtgacctctgaggctgaaagga ctaaggactcctttccccatcatttcagctgggccagtggctggctaaaatcagcgcagcattcccattc- ttctgaaagccacagctgaaataatgcaccagct gaaaccacagtggacagactgagatggcctccctctgggcctctagttggcaactttctcacccgggggc- tcctctttctccttttcccgctccttgttccagtc cttaaggccttctggaagtgaggtgtcctcatccaagctgccagtgccttccacaaattcttcataggta- gatttttccgcaaatggtctggggcccaaaa 615 3931281 -- NO cccgaggagcttgtgatgtcaccagtgtgccctgcgggatctggggaacaggagaagtaggccagagaagtcg- ggttgaaaggtgtgtcgtttgcgtcct ggatctcccttaatttaaccccataacattccattttacagataaggagactgatgctcactaagacact- aatatgcccactcacacagcaagtcccaagtctct ccccaaaatgatttgagaattttgaggcacacaaaagggagaaaattgagtgcccgtgatccaacgactg- caactgtaggaaaccaggaaagtggagga gtggtagtacttctgaacccta 616 3110077 -- NO tgggaagaggattcggactcgtcacactgcagagcagcagagcgagaaaggatgagaagaggcagagaaggcg- acggcagaagaaaaaaggaaaa actgcggccgcgatcagagcctga 617 3419463 -- NO gcgccctcgccctgggaaactcactggagtggggacagatctcaggcgtttggcagtcac 618 3903370 -- NO attgtatttctattggacgctgctgctctaggttactgagttt 619 3609638 -- NO agaatcaggaaaattggtgcagggattggcacactgcagggagaatgcatgggctccatg 620 3227685 -- NO tcttgggtactcaccttcagccctagagcattctttagcactcacagtttctcttctcgtcgggttattcttt- atattaatcttttcctgtccaaattactctctatgtctcc tgatcagtccttgactggaagcatcaag 621 3349840 -- NO cataacctctagagtagaaagtttcagaaggaagagattccccaaactgtgtaattcccttgtaaatctcatt- cattcaatgggatttgagaaccaaccacttgtg caggtgcccgcatccgaagataacttgcccccaggagacagcagataagaagagggcagagacaaaggag- gtctttttgcgacttgcatc 622 3035683 FTSJ2 NO cccatgtgtgccttgacgggacttcatcttatagactgttaaactgtcacacacaaacaggctttccacccct- gctctgagagcaccacgcacagatttccagt tcttagtgtggctgtttaaagtagaaaatctgggggctgggtgaggccactcatgcctgtaaacccaggg- ctttagaaggctgaggctgggggattgcttga agtcaggagttcaagaccaacctgggcaacatagcaacaccccccatgtctacaaaaatgaaaaaccaaa- aagcaaaccaaaagaaaaatctgaaatttc catctggggattaacttctgtctttctggtgaacaatatagcaattcacgcattcttcaagcagcaaaag- ttcccggaacaattagggaagacgtatggtctgaa tttatccaggcagtgggtctgctttggtttttgctggaaatttatatcagtgtctgggctcccaagaaca- taaatgtaattgccaaagcaagcagtgatgtggtgt gtttattttcttttactcatctaggaacttgacgcagcttta 623 3439354 ZNF84 NO tcaagaaagagtcccgattgtgttccagtacctggttcttctggtct 624 2812078 -- NO ggcagtgctgtagggagcttcattaattatgatagtctcgctgtgtcaaatggattacaaatggaaccacctg- tggggagcctgcaaggttacggacagagg cta 625 3038635 -- NO gatatgaaaaagcacgcatgcaactaactactgttgatctgctttgcta 626 3088092 -- NO acaagagggcgggtacaaacgcacagcttccagggctgaaataca 627 3337338 ALDH3B1 YES atgaaggacgagcgtgtgcccaagaacc 628 3420557 -- NO gtaagttgcctgtcgctcctctgaatttt 629 3841267 CNOT3 YES atggcggacaagcgcaaactccaag 630 2929962 STXBP5 YES tcaaggagccttgcacagcatattcctggccctggtggcattgaaggcgtaaaaggggcagcatctggagttg- ttggtgaattagcacgagccaggctggc actagatgaaagagggcagaaacttggcgatctggaagaaagaactgcggccatgttatcaagtgcagag- tc 631 2387074 MTR YES gttgaggattatgcattgaggaagaacatatctgtggctgaggttgagaaatggcttggacccatt 632 3388958 -- NO gtaggtgccgaacaccgcgagtctccgcgcccgacccgacctcgtgttcgagtgtgtgcacgctggcgtttat- ggagagactagaagagccgcccacgtt aagagtctacgtgccctgcagg 633 3620562 -- NO cccaaactgaaacatcatacctatta 634 3870278 -- NO gtttgacttctgactaaaggtcttg 635 2833045 RNF14 YES tacctgcaagcggatgaggctaataaaag 636 3030300 CUL1 NO gattgctgcactggacgactttagaacatccctcaca 637 3767510 -- NO agatcgaggacagtgttgagacaccaccacctc 638 3039444 -- NO gttcaaacagtagtttactcctgcctcag 639 3067653 -- NO agtatgggagaggggtaatgctgagca 640 3139926 TRAM1 YES aattaacaggcgaatgcacttctccaaaacaaaacacagcaagtttaatgaatctggtcagcttagtgcgttc- tacctttttgcc 641 3203423 B4GALT1 YES atgtctatatctcgcccaaatgctgtggtcgggaggtgtcgcatgatccgccactcaagaga 642 3875984 -- NO tctttctctgggttcatttcctaactgtctaactttggg 643 2848542 -- NO atggtgtggcaagttgactgtatcgtgatgttagccgtcttgtggcagaga 644 3134299 -- NO agaccacagaaactgggcgggcagcagatgcagacacagccatcctatgcatttag 645 3538031 -- NO tgaccacgtgcgcaaattatttttcttttttagtagaatggtgcattttttgcctttgtatttgaaatttagc- taaattacaatagctatcagaactacaattgaccttagt aatttcaaaaccatagttataagggttttaagttgatttttaaaaatcttaagatatgatagggatttca- aaactatgtgtgtgtatctctgatagggaggggttggg gcacagactaataagtgtgccaaaaatctgtgaatccaaatgtgtaacaagtgttgtctgaataaatgtc- cacaaatccatgctattattg 646 4037525 -- NO tgtattagaatgtaatgaactttaatggaatgtactcgaatggattcgactggaatggaatgttctggaagtg- aatggactccaatggaatggattcaaaagga atggaatcgtacgga 647 2814589 BDP1 YES agcttctgacatctctggaggtttcagcaagaaaagattgtgtaggttccaaagagtctgctttggcaaaaat- agatgcggaattagaagaagttggaccatc aagaagggttggagaggaaactgtaggagataattcaccatcttc 648 2823139 -- NO tcccaacctggcagtgctgagtggg 649 3113389 COL14A1 YES ggacagaaccagctacaaccatagtgcctaccac 650 2853728 C5orf42 YES cagcagtgagagtcgtccagtccatggctcgtttcatggctgcctatttcaccaatcagcagctttgcatttt- gccccctca 651 3895815 RNF24 YES gctcggatttcccacattacaacttcaggatgcctaatattggattccagaatctgcctctcaacatatatat- tgtggtttttggtactgctatatttgtcttcatcctta gtttactcttctgttgctac 652 4013748 BRWD3 YES ttgttgatttagattcagacggtcctggtacttcat

653 3384440 -- NO ttgtccttgggcaaacgtggtatactttctcagtggtggttggaaggaaatttgttgccctgtcatttcgcaa- gtatggaaaaagacctaaaggagaatttagca gctgcagccgctgtttttattgcgtactttactagcgccaactctttaataatcgcttgttagttgttac- ccctgttttatgggtcaagagactcaatatatcagtactt tggtaaggccaggcagc 654 4026568 FAM58A NO aggccgggagtgtactgtgtgcagctgacccaaggcagccacatctgcgtttgtcctttgagaggactttgac- tacaatacaggcatgacatcaatgaaagg aaagtcatgaaatcgatgagactgaatccctacggatttcttaaaagccagatttgtagggagaatgaat- gtgca 655 2675946 WDR51A NO gccagggatttgtaccatgggacttgg 656 2941689 -- NO tctccaactgcagcgacctgtggctcttcagat 657 2330052 EIF2C4 YES gaaggcagtcatgtgtcaggacagagcaacggccgggatcctcaggccttggctaaggctgtgcaaatccacc- atgatacccagcacacgatgtattttg 658 2726487 OCIAD1 NO cgcagtgaggtctgacgtcatttcc 659 2902605 LY6G6D YES ccccagtgaccttgattcaccaacatccagcctgcgtcgcag 660 2732332 -- NO tcaaaagatttggagtctagagggcagaaattgaagaggttggtgctctgcacgtctgagtccgcccacagac- tgaataaat 661 2329455 -- NO ttcctggatcacaaagggctgtaggggttccagagatgctggagctctggtacaacaggagggccacaggc 662 2373856 PTPRC YES gtatttgtggcttaaactcttggcatt 663 2465069 SMYD3 YES aaaaagcttggccagaccacaagcgggaatgcaaatgccttaaaagctgcaaacccagatatcctccagactc- cgttcgacttcttggca 664 3046899 VPS41 YES tgatggcagctgaaattagccaaaa 665 3418387 GEFT YES ttgccgctttgcactgacctccagagggccagagggtgggatccagcgctatgtcctgcaggctgcagaccct- gctatcagtcaggcctggatcaagcatg tggctcagatcttggagagccaacgggacttcc 666 3568670 -- NO ttcttgcagtagtgcgtgagctctcactcttgctctggggagtctggattagtccttgagggaatggattagt- tcctgcaagggtaggctgttataaagccagga tgctctcaggctctcctctgtttgcatgggttggcttcc 667 2824307 -- NO aggcacaggctcaattagtttttcaaactctagccaaggcagtatttcatttgggaaatcatgcaacagaact- gctcaattcttaacttctcctgctgttaacattta cacttagactgccagcaacagttaacttaaattttggtctcaagggaacaaaaaaaaattgcattcagaa- tttaatatagtattttaaaactaattttagcctgtaag tcattatgagcaatagtaacttttgtacctcctcatcttgtctgataatatattctatatgctgtcaatc- tgattatatagtctatatgctagaagttgctgattttcattct gccaccaagaaaactgtacttttatttatgggaaaaggatttaaatactcctagatacttaaaatttttt- taatctaaaagttgattttctcccaagaacaattttgtttg ctttctacaaagttttaagtttaataaaatgccggtaatcaccactgttttcctccccaaaataaatgct- ctgatccatattatattagagtgatactgtcacttagtat tgatatctttaatattttttacatcatgagacattgttatgatcttacctgattgttatctcaaggtgag- ctaatcatctttatttgccttaaaaaatactgtactggctgg atatttaatcttgttagtttagttatacacttgttttagtcgagtttaattcaaaaggactcttaacagt- atggtgtaaaactcagattttctagtccagacaaattgctc tctataacgatttggcagatcaatggagacatccgttttaactttactgttctgtacttactatgtagtc- atgtgcagcttatcaacacaaagaatacggatgaggg catttaaatggactacaagtgactctgacttgtaaactagggaagcctcttgtgtttgaccttaaaggcc- agagaaaaactgaagatagattgacttaactattg ccaagcagattatgggttactttatacttcctttcattc 668 3204568 -- NO agccctcaggccctaccaaccttgactgtcctgtccc 669 3410647 -- NO cccaggagtactagttgagggccaggctgctgagaagcagttgaagtagccttgaagcaaggatgggagattg- ctgggtgagatcaaagatacgctggg atgggggtgagtgaaagtgtgagcaatgagtagaggcaagattgtagatgctgcatttggaggaatattt- ctgactgcataatcagaggtcagaatggctag agaaattaatacagaggtacaaggctagatttagaagagtaagctaagaacagactgcaatgggcttttg- aatg 670 2555029 -- NO catccacgtacacatatgagctgtacacatagatgttaatcaggttgcttttttcattttatttaaatattca- aaatattgtgtgattgtgatccattgagatcattgaag tagtattaatttagctgggaattagcagcttatgttgtgtgggcccagttcatcaatatgtgtgtcaaat- atccaccctcagatatcagcagcctttgacttgcagt caga 671 3238290 MLLT10 YES tagtaccttaattggcctcccttca 672 3490689 -- NO tatagaggaaacctatcagggcagggacagt 673 3571835 -- YES catccatggattgggcccactactcatagcagctcctgaggcaggtaaatggggcaaggactcacgccaaata- ccacacgcgtatgtcaaacacccaagg tcggattctggggcccctgccctcaggaggctgtcagactgttccccctaaacacacttctgaaggttgt- agggaccttgccctgctgtct 674 2318698 PER3 YES ggggcacccgttcattacttcgagaagcagctcacccttgcagttaaacttacttcaggaagagatgcccaga- ccctctgaatctccagatcagatgagaag gaacacgtgcccacaaactgagta 675 2330382 -- NO tggcccagctacatttgcaatgatgtgcacgtaaacactgttaagaggttaaagcttgtatacaatctgttac- tgtgaaataactaaattgggctttaaaaaaatct tagtatttattgatcttcattcacatatacagttgaaatttaaaataacagatggttattccaatgctgc- tgaaaccttttctaaaaaatacttgttttgttggttgaatgt gatgagaggcgcttctgggcagtctctcttctctcccacccgtctttcctcctccgagtaccccttctcc- agctttgtactagccatgtaaaacccaaggttttctt taaaacatcagaagagatctcgtcctccatgccccaaaaaagccaactcattggaggtgttaccc 676 3837059 GRLF1 NO ttgggtgttgaagtggaatcgtttcatcccagcc 677 2582942 -- NO tcaatcaggtcaaccacaggtcatatgaaaccatcttcccaactcccccacctccactggttctgaagagtgg- gtgtaaacaatgggttaaacaatccaggat gcagacagctgttaatcataactggctccaca 678 2876012 -- NO tgtctcatctaccaattcctgctattataagatcaacttctgcaaaaaccttatccacctcaagtatccttag- cagc 679 3372066 NUP160 YES ctttgccttaacttccacggatatctgggccctgtggcatgatgctgagaaccaaacagtagtgaaatacatc- aactttga 680 3781765 C18orf8 YES gagatgcctcataaatttgtgatagccgtgctgatggaatacattcgttctcttaaccagtttcagattgcag- tacag 681 3278980 DCLRE1C YES ctggatcacaggtgcataccgccatgcc 682 3435777 C12orf65 NO gttcaagtgcaatgacacacgcctataatcccagcaccttgggaggctaagacaggaagatcacctgagccca- ggagctcaagattgcagtgagctatga acaccactgcactccacctgtccacttgttcttgtgtgacagaacaagaccctgtctctaaaaaataaga- taaaaccataaagaaacacagtcagtactataca agaataatggctacttctagagggaaggagttgtcattgtgatgaggcacttggaggggttctggggtgc- ctgacaaagttctgtttcttcacctgggtggtag ttagaagggtgtccccgtatttcaaattgtacctttgtgagattgtatg 683 3524572 EFNB2 NO gctaggctgtctgcgaagaaggctaggagttcatagaagggagtggggc 684 3790001 -- NO cagaacaagtgcatctgctggcagccagcttaaggagttagcagccctcaattccaataacgaacgtgtaaat- cagaattc 685 3301881 TM9SF3 YES gaaggagatggataaagcagatgtttattggggcattccttatcccagctatggtgtgtggcactgccttctt- catcaatttcatagccatttattaccatgcttca agagccat 686 2745373 LOC100130178 NO tggcagattatgtggaccatcaacaaactaccaaaa 687 2774241 -- NO tgcacagacaattccctttactaggtgtcaccatagctaccatcttcatctccttcaaatgttgctttggcat- tgaggcttaccctcacttccttatttaaaattacaa ccagctgggcgtggtggttcacatctgtaatcccagcaattttggaggccaaggtgggcagatcccttga- gctcaggagttagagaccagcctgggcaaca tggcaaaaccccatctctataaaaaatacagaaaaaacttagctgggtaatggtggcacacacctgtagt- cccagctattcgggaggctgagacgggagaa tcgcttgagcccaggagatccaagctgcggtgagtc 688 2852754 AMACR YES tacgacttacaggacagcagatggggaattcatggctgttggagcaatagaaccccagttctacgagctgctg- atcaa 689 2390973 -- NO tttgccagtagcctcataatgagcgtgaggtagtatctcattgtagtgttaatttgcatttacctaacaattc- gtgatgtggagcatcttttcatgggcttgttggctg ctgtgtctcttctttggagaagtgtctgttgaagttgtttgacattttttaatcaagttgttggacaggt- tcccttgtttttaagtcagagtaggtgatgtttgtcttgaa ggttata 690 3457600 ANKRD52 YES accaagagaggcgaactccattgcatgctgctgcctacgtaggcgatgtccc 691 2853708 C5orf42 YES ccttattccagggatgctgacattccatttctaactagtttttctggaaagcttagagaacatgaacttaatt- ctttactttttgatgtacatacaacattaaaacgac atcagagcaaaactaaaagccagaatgtgtttagagctggttcttgctttgttgttgctcctgagtccta- tgaatcagaaaaatcatcctctttaaatgatgaatat ggcatgcatttagaaaaccagaaactttcatcatcagtactggttaatcaagggatca 692 3055843 -- NO cccagatggagacacccatagcagggcgccggatccaatctcttcctctcctccctcggccttcctctcccca- caaaccccagggtctagaaagtagaagg ttctcccctcttctctccttcctcataatgaactcgatgg 693 3139045 ARFGEF1 NO catggtttgcggaggttagatttactggaaatgtattcatactgtgaattgtgctctgatggttaaaagacaa- gattgtcaagcattccgtattaacagtggatgta gaaaattttttcagatggacaaaatgtatatggtacagatgtaaagttttctatgtaaaaaattctgtac- aactttctgtacaatattgattcccatctggca 694 3607791 WDR93 YES ctgcctatttgcaatgccaccggaagtcaagggccc 695 2666907 SLC4A7 YES accaagaaagaaatacgtggatgctga 696 3887309 -- NO ccagcagggggttcccatccttcct 697 2333654 DPH2 YES tggaagacgagggattgccatcgcctatgaggatgagg 698 3333566 LOC751071 NO gtctgcggacgctgtataccctcctccac 699 3278417 FRMD4A YES aagccagagaagctcgacaccgtcaagtgaaattggagccaccc 700 3986088 NRK NO tcgacacggagcacccttctagcttcttcgtctccaggactgacgctcaggctcctctctcgccttagcccaa- cttgctttcccgcctcgcaaactccgg 701 2558398 LOC100128333 NO tgcccaccagccaactagacagatgtggcctgcattgtccccctggaggcaaaggatgtgtgggtatttattt- atttaagatagtaagttatggccaggtgtgg tggctcacgcctgtaatcccagcactttgggaggccgaggcgggtggatcacctgaagccaggagtttga- gaccagcctggccaacatggtaaaccctgc ctccactaaaaaatacaaaaattagctgggcatggtggtgcatgcctgtaatcccagctactcgggaggc- tgaggcaggagaatcgcttgaacccaggag gcggaggttgcagtgagccaagatcgtgccactgcactccagcctgggcaacagagcaagactccatctc- taaaataaataaataaataaataaataaata aataagacaataaattatataagcagtgctgaatacagcttcatcatttaaaaatccaaacagtttggaa- atatatagacaagtatataaatgctcttcttgcaccc cttcccccatcctaaagcctaccatacaggtaggcactgttaattatttggtggaaatgtttacactttt- tgctttgcatttacacatgtgagtggcagggatagtat ctgagaaattaatttttttctctcctgaattttctctttttctgccctcacatttatggagctcattacc- tccagagcagcttttcaggttagaaaactgaatttatcttca ggcatctctggcttttgtgtgctgaaagcttaagcatttagggcaactccaggatttgctgagtggctca- tcaaaggatgaggattctcttgcacagactgaa 702 2830633 -- NO gcattgtgtatgctgaagccatcatcactctcgctcacaggaggttcattatccatttctgacaagtagcctt- ctccttgatcctcttccttaggc 703 2546259 -- NO tatacccacatcactaagctgggaggcacattt 704 3615631 TJP1 YES ttccgtgttgtggataccttgtacaatggaaaactgggctcttggcttgctattcgaattggtaaaaatcata- aggaggtagaacgaggcatc 705 3729022 GDPD1 YES gagctcccaccttaccttggcaaactggatgtctcatttcaaa 706 3729073 YPEL2 NO tgatggcctcttgtcaggagagcagtggcacgggggcgtgaggaagagggaaaggggaaactctaagggtcct- ggcgcggggaaggggtggaaggg tggaggtaggaacaaaattgcgccgctcctggagacctgataacttaggcttgaaataattgacttgtct- aaaagga 707 3043777 -- NO tgcactacatcgctggcaagaattgttcagaaaggctggcctgctaacgacttctggggagattttc

708 3080463 -- NO aaggcacctacacaacatcaggccacttgg 709 2969705 REV3L NO ttgctaataaatgtaggccggaggggatggcttagtggtctaagcatcagatttgaaatacctagagtccctg- gaactgcaggtttgaatgtcagcagagtca acccagc 710 2904894 MAPK14 YES attctggattttggactggctcggcacacagatgatgaaatgacaggctacgtggccactaggtggtacaggg- ctcc 711 3421016 -- NO atgcctccagtatcggatatgtgggcaggcacaa 712 3724753 NPEPPS YES tgggttttatcggacccagtacagctctgccatgctggaaagtttattaccaggcattcgtgacctttctctg- ccccctgtggatcgacttggattacagaatg 713 2600045 GLB1L YES tgttgtggagcgaaatatgagagacaaactatttttgacggggaaactggggtccaaactggatatcttggtg- gagaacatggggaggctcagctttgggtc taaca 714 2893581 -- NO tgcatttcagcttggagtgcgcagcatgaggcatttgtggttcagaaaagaggtcttcctttttcctcctcct- gttttcttttccttccttctccccaactccccaaag gcttactgcctttcttctcaggccacgtgtgtagataacctttgaggaaaagatggtttccgtgctggga- tatttggatattacctaaagggacaagatgagccc tttctttgccttgttttctttctctggcctcatcagagtgaattatatctgactgtgtgacagttaattg- taccatccatcccgtgtcctaagctgataagccc 715 3712473 MPRIP NO gtgtgtcccatccaagttgagcacgcgccttccccagcttgcagcagcacaccccaagcgctgcttttcacct- gtacctttgttttattattattattattattgctgt tgttgtcatcgttaactgtgggcatggaa 716 3026735 -- NO ccatgatgtgaaaggtcgggtgatatctgagagctgaaggaggttaagcggatccatgccaggctgacaaggg- gaacaggtgcctctgccctggactgg agcctacgcaaccatcttctgctttatctagctgctgtctgtctcctgtctctgcgtgagtgtgtg 717 3603221 IDH3A YES agtcgtgcagagtatcaagctcatcaccgagggggcgagcaagcgcattgctgagtttgcctttgagtatgcc- cggaacaaccaccggagcaacgtcacg gcggtgcacaaagccaa 718 3820895 CARM1 YES ccaggtggaccagaccggctccaagtccagtaacctcctggatctgaa 719 3183801 RAD23B YES agaatgagaatttggctgccaattt 720 3420741 CAND1 YES agaaaaaagtgtgaagacccgacagtgttgttttaa 721 2356132 TXNIP YES cctgctatatggatgtcattcctgaagatcaccgattggagagcccaaccactcctctgctagatgacatgga- tggctctcaagacagccctatctttatgtatg cccctgagttcaagttcatgccaccaccgacttatactg 722 2625835 SLMAP YES ctttcaaagagtggcggggactgcacttttattcatcaat 723 2996070 AVL9 YES gtctgtcacctcgagatcttgtccttcatttt 724 3175548 -- NO cctcaatgggaaccctggtgcagaa 725 3810034 -- NO tagctgttcaggaaagctgtgtggctggagcagagaatatactggaaatcagagaggtcaaaaacaatgagca- ggagatatcggaagaaatgttcctaacc acttcactcttc 726 2767097 -- NO agtatttcatgacaactctaagaaggacagcactcaggggcagaatccgcaaatatcacctatttccaattat- acttcacatgtgcatatgtgcacacacgacg gctgtc 727 2853747 -- YES ttattctggggaatgcctgaagttaacatttctagcaattcggtggcatgagaatg 728 3016374 -- NO cgcagtttgtcagcatcgatgtgggactgggagaggaaggatattgccagttatggttga 729 3845911 LMNB2 NO tttatggcctgggaaacaatttgcatttgtccccaaatacgcttagctgtgtgccgcttagaacgatgcgaaa- ccatccctctgtgtaagcccgtg 730 2642763 -- NO gtggcaggagtattttcaccaaagaaattaaatgctacaaatcctaccaccacaccactggtttgggctcata- gaaagtttgttaagagtctgtgacatgaggt ggcctctaatacagtgagttcaatatttgaacttctgtaaagaaaaggattagatttattcagtatgatc- ttaaagagggatgctaggggcagcaggtaaaaattt cagggagacagattttcgttcagtgttgggaaactcctgaggtaagaagtgcccattaggctgggtggcc- actcaccttagaagagagatactacagagaa ggctgaaacatggaagattgtaggggttgagtggctcattagtttggccaccaaatc 731 3642784 PDIA2 NO tgtcacccccgccatcactgctggacaggagccacccccttgggtaccagagggagctgtgcattgtgaataa- aga 732 3178621 SECISBP2 YES tgttaccgaggttttcaaacagtga 733 3681988 KIAA0430 YES cgatcggtgcagtgaatagcctccacagatacaaaattggcagcaaaaagatcctggtctcacttgccaccgg- ggctgccagcaaatcactctct 734 2973750 -- NO ggagcgtgggagttcatattttacactatgttggtacttaccatgcaaatgaacggccctgctgggaaaagaa- cctttatccagagaggggatccgaggaaa tagtaagagttgggttccgagaagctgtgctgcatcacgggagagctcggtgtta 735 3284084 EPC1 NO atggtgcggaacctgctgttttatctatttattgtgccgtgtttacagttttttgtacactgtaccttcattg- gttcctgtgctgtagtaaatgtgttaggtagctgtgga ctccttggtattttgtaaatggtataacataacttggttcccctctgggtccttgagttttctgtgtatc- atgtgaaaaaaaatggtgacatacatacagaattttaca aaaaaaaaaaaaaaaaaaaaggcatcagtttttttaaaaatggggaatgtactattaaatggggatcttc- ctggtctactatcattaggacaagtaacaagctaa aaatgaagtctcttgaatctttccatccccaacttgcccacaaagctgtgggtggtttctggtacttaaa- gcactaatattatgttgctgctctgcgaacagccca gtagtcccattt 736 3642301 -- NO ccacaggagacacgaggccgaggtggcgcagcacccaccctacacagcagtggccatgtgccaattacacgtg- ctgggaggag 737 3133236 PLAT YES tgtgtctgaacgatggccgcatgactttggtgggcatcatcagctggggcctgggctgtggacagaaggatgt- cccgggtgtgtacaccaaggttaccaac tacctagactggattcgtgacaacatg 738 2858415 -- NO gctggtaataatcgcgtttttggtaaaaacacctcatggaatttttttcctttctcataaaatagctgatact- gtaaaattgagatagcctctcaagtctggaacacc tttcaattcatcaaaaagggacaacctaatattccaaagaagactcaatccttttaacacacatacattt- tagggccagtcaagagaagtggcctgttctgtagg aaaacatttcttggcacattattattttaagtgattgcaggagaccacagagggagagaaaagagacaac- aacaacttctagcatgcctgggggatgacttgc tctttcatatttgtggaaccctatgtcaagagagaaaacatctaaaaataaaaacgcatttactcagatt- ctctagggcaaggtgcaa 739 3301253 -- NO cttgtggcattgtgctaaagcaaaaaggaatggaatttgcaatgagagagcctttcaagttcaggctcagcct- ttagctgtgtgaacttgaaccactcacaattt ttctgaatctcaatttcctcatctgtaaagtttatctaatatgttggtggtgaggtaatcatattattat- ctcaaataggagattgtatatgaaagggctttggaaagg caaatcccattatttgtttaaatcaattttttcccctaaaaaagatagctcataaaagaatgtgaactta- atctgtatgtgtaatttctttcaagtcctatctgatgttgct tgtgac 740 3068212 DOCK4 YES aatgcctgtagtgtccagtaccgacgaccctttggctgtgcagttcttagcatcgctgacctgctaacaggag- agacaa 741 3664307 -- NO ccagcaattctgaggcagggaccaatcaga 742 2357616 LOC388692 NO atgtggattgtctaactggaggttgggagtccagggtgcagaaggagaagcttggagtgcaggatttggtggt- atgtgtgtggcagtaggcactatgttctaa ttgccag 743 2824047 -- NO atgaccagagtcataggtggtgatgt 744 3348756 C11orf1 YES atttaagcgagagcctcactggttcccaggacatcaacctgaactggatcctccccgata 745 3561991 -- NO cttatttgatgggtggccaagatactgggtagggtggtgtgatttgctatactgagtagatcagtaaacaata- aagtataaatcttgctttgtagttggaaggtca gttaacaaatatttagtcaatatgatgctggagttggctaatgtatcccccaggtctaattaatgaaaat- aatcttgcattggtctttaggaaaatcatttttattctctt tctgaatacttaaccatagttgtttacatgttttactgtggaagtaatatcttttatgaatgttttagag- aaaacaattatggttcacttggaccattcagtaatttgtcc agcctggctagtttctagttatctga 746 3051857 -- NO agagaagaatcctccgacggcttcgttaccatcctgtctgaagcggattgcacgagccc 747 3459696 -- NO tgagcttcacatggggtcaaactggaaagtatctctttgctatgctcccatttaattaaattaggaaatctgc- ctaaaacttgaatcactcctcttttcagctggtgg ccaggcaggaatgctccctgaagagtactctttcaatagacttcagaatgtgttacctgaaaagtgctca- tgatgaatcaagacatcactgtgttttccatacttc tgaagtagagattgtccactaacagcttagggaaagcagagtacccgctcagctgctctttttctggtgt- ggtcagaccagctgggtcctctgaaacatgaat ccatagtgcttcctttgttatactatttctgactcagttttctctaaacggctgtaaaatttaactgcct- agctgtattttctttctgtggactttatgctctcatatttagg agaaagaataagagaacaccaacttacatctctgtagctctggatgattattaaggccctggtctaatgc- ttaaaggtaagcatctgttatctatattcaataaaa gaggaaaatgaaccccagagagaaatcaagttactttagaatcgcaggctgtcccatgaccctggtgacc- atcactgaatta 748 2614179 -- NO gtgaagccatcagtgtctacagcttcagctattgcccgtgtgcagatggtgcttaatctctcttgtgccttcc- agacctgcatt 749 3047613 -- NO attaggtgatggtagcggactagccgacggagggcaggcaggggagggggagaggactttacagaaaaggaat- tctcggtcgagctctgcctggagat gactggcttacacttactaaacccagcgggtca 750 3677890 CREBBP NO atcaacagccgccatcttgtcgcggacccgaccggggcttcgagcgcgatctactcggcc 751 3177929 DAPK1 YES tgacaattcaagatagtttgcagcatccctgg 752 3211613 TLE1 YES tcctggtcccagacagtctaagaggcacagataaacgcagaaatggacctgaattttccaatgacatcaagaa- aaggaaggtggatgataaggactccag ccacta 753 3452723 RAPGEF3 NO tgtgagaaggtgaagcccataaggcacagaaggagttcagtgagaccagtgacttcaggctcagtgtgggaga- ccaggggaaggatgggcatgcagg gggcgggggactaggctgtgggggaggcaggatgcatggaaggtagggaaggctgaggaggtggagccaa- agtcggaggtgggagaagggctgtg ggtccctgtgggaccctcatggggctcaggggctggaatgaaggaggtagatgagagggtctaaagctgg- aacatcatgagttgagcatgggatg 754 2845333 -- NO ggggctaacatggacggtcaggagctacgt 755 2852760 -- NO tgaatgcctgaatctcaaacttgtacttcatcatggactccagtcttcctttcacatccaatttcaatgatca- tcaatacagtcattttgctccttagcccactcggac tatttctctccatacctgctgcaactgccttgacactggtgtgacagccttttaaaaactggtgtttggg- gctggtatcactccagtggattc 756 2750640 -- NO caataagatagacggaaatataatatttaaggttagagaagaaggctgagtgtggtggctcactcctgtaatc- ccagcactttgggaggctgaggcaggaca atcacttgagctggggagtttgagaccactcagactcacttgagacca 757 2807722 -- NO ttcttatgcaaacaacaccatctgggctctggaacttcacaaaaggacactgttaagtcacac 758 3338718 -- NO tcatccatcaggctgtgtcagacgcacctgagccctc 759 3482760 -- NO tgaccccagacctagggttgctggtgga 760 3884900 -- NO tgcttcgattgctttcgagtcatgagttggtg 761 3038653 -- NO aaatgtgggcccgttaaagagcaagactctagaaaggaatctagccaaagaggacagcgttggtgggatgggg- ataa 762 3340340 RNF169 YES agtcagagctgtagtgacacagcccaggaaagagcgaagagcagagtcagagcagttccaggcaacaaagcca- ag 763 3441973 -- NO agtgctgtctacacgctgagtattaaatcctaaatgtgtatattagctgacaacctctcccttgaactctgca- ctcacataaccaacaatctaaacctctccctcc catatgctaccccatctcagtaaatggcaacttcattcttctagttgctcaagtcaaa 764 3629351 SPG21 NO acccggtgtgttcttgtatagtcagtggcatcagcacccgtcagccggccttttccttcaggttcgtcaggct-

caccg 765 2611420 -- NO gtgctggcaccatcgagccacaactcaggggcctcatc 766 3371610 -- NO acagttttgagacaggtggttcaggtg 767 3795789 -- NO gcctggctcttccttaccacccggattttgtttttgctttctgggtagagctctgatgttgccaaacagcctg- tgctcctcgtgaacaatctctccagactcaaaat agcgagcagccaaggggctgccactgcttgcggtccacag 768 3118031 -- NO aggaaataactttacatgtgctcctct 769 2976043 IL20RA NO tcctgtgcaaacaagtgagtcacccctttgatcccagccataaagtacctgggatgaaagaagttttttccag- tttgtcagtgtctgtgagaattacttatttctttt ctctattctcatagcacgtgtgtgattggttcatgcatgtaggtctcttaacaatgatggtgggcctctg- gagtccaggggctggccggttgttctatgcagaga 770 3330211 -- NO attactgaaagtggcgtgcactgaca 771 2397801 -- NO atgccagagactgtgatgttggaaa 772 2537317 TMEM18 YES aatacatcaatgaggcggctgcgat 773 2875953 -- NO caatagtgcaatatcacgaccaggatattaacattggtacagtcaaaatacggggcattaccatcaccacaag- gatatctcatattgcccttataaagccaccc cacttccctcctacctcacccctcctgaactcctggtaaccacaaattatccatttgtataagttggtaa- ttttgagaatcttacataaatggaataatacagtatgt aacttttgggattgactttttttcacttagcataattctctgaagattcacctaggttgttacatgtgtc- aatagtttgttcctttttaaattttaacttttattttttcgagagt aagtcttgcactccaggc 774 2882417 -- NO aggaaagcatgagaggtcagcagca 775 3095010 -- NO catgcagtacattggatatgatataatttatggtttcttgtttgcagctgtttgtatctttttaatcccaaac- cagacaaaattataaacattttatatacaatgttatctt ggaaaaagttagatgtaaataattcatcttaatctatatttgagaaatctgaggggtattaggaaactca- tgagtgaatgaacatatagattggatcaaaggagg agagtatgagagtagggagaccaggtaaaaaggtatcatagtcatc 776 3450794 KIF21A YES ggatgctcctttaaacagcccaggatcaga 777 3627349 -- NO tcttctggctcttccgtgacgcattacaacagcca 778 2360857 FDPS NO gggagcagctgatcaggtttctgac 779 3821204 PRKCSH NO gtgcggtggatactgacctttgctccggcct 780 3665595 FAM65A YES tggaggatgaggacgtgcagactcgagtggctgg 781 2852747 AMACR NO caggcccacggctcaagtgaatttgaatactgcatttacagtgtagagtaacacataacattgtatgcatgga- aacatggaggaacagtattacagtgtcctac cactctaatcaagaaaagaattacagactctgattctacagtgatgattgaattctaaaaatggttatca- ttagggcttttgatttataaaactttgggtacttatact aaattatggtagttattctgccttccagtttgcttgatatatttgttgatattaagattcttgacttata- ttttgaatgggttctagtgaaaaaggaatgatatattcttga agacatcgatatacatttatttacactcttgattctacaatgtagaaaatgaggaaatgccacaaattgt- atggtgataaaagtcacgtgaaacagagtgattggt tgcatccaggccttttgtcttggtgttcatgatctccctctaagcacattccaaactttagcaacagtta- tcacactagtaatttgcaaagaaaagtttcacctgtat tgaatcagaatgccttcaactgaaaaaaacatatccaaaataatgaggaaatgtgaggctcactacgtag- agtccagagggacagtcagttttagggagcc tgtatccagtaactcggggcctgtttc 782 3004680 -- YES tggatgagtgtaagggacaccaaggaggt 783 2722233 -- NO tgaaattcataaaggcatgtgtgcca 784 2805960 -- NO cccagggcattagagtgacctcacaagagtatctcagaatatttaaaaatttgaacacacaaacacaatgaaa- ctcaacatctgtcagacatcacgtgaacta ctagtgaggtagttcattctttcaacataagattgcactataatccttctgataatttcatatttttgtg- agactgggttttccaggccatctgataaaaaatcaagta ctatatggacaccaacatggagcagaaaatgagggcagcagtgtccaatctcattccaggtg 785 2952396 -- NO aggaatggaattaataggttgtggcaatatcaa 786 2612927 -- NO caacccaatctacagttgtgggcagtggct 787 2640231 -- NO tgcccggcctgcaataagtatttctaaataagatcacattctcagctacaagaatttaggatttcaacatctt- ttgaggaggactcaatttaacccataagaatact atgtgggccacacatggtgcttcacatctgttatcccagtatttcgggaagttgaagcaggaggatcatt- gctcagggcctatggggacaccgggtgcataa gaccaca 788 3371122 SYT13 NO agcaggaaatggaatatgcgggtcacactg 789 2972930 -- NO gctgtgacacaacagtgtggcgatgtcccacagacctgaaa 790 3529011 -- NO agcggctgcagcacgtagttggagaaggtgagggcgatgacagcctggttggtggggtagatcaccagcacag- caatcc 791 3670860 LOC100129617 NO gagccagccaccacgttagattttagagtctcctggagcacgtgaaaacaactgaaaaagggtaaccacacat- catttcacttgtgatgtagcttgcctgtctc cacaccatgcccctgaagaatagtatatcacctacagccccttccccagtcaggaatggaagtgcatgac- acatgtgctcctctaccccttccatgctcatgg cagacatcattaatcaattatagcactctttctgtagagccagagacagcatcacactctttcccctcct- gcattccaggccaccactaccaactgaaatcgtgt tagtaccataatgaatgctatgtaccattctctaccctaagcgattgcaaactgtaaatgaattgttgct- gatttctgagcccctcctagatttggggtaaattcattt cttgttttcagaacacaggggatagggacaccctgtgcagttctttctccaggacaaggagactccccac- tgggggatggggcggggtttctgccttaatttg ggcgctcatagtttcaaggaggagctctttctggctttggccagctagaaggaaaggtgccctgtttgtt- aactttaaaatcactacgggtgtagtgtatggagt gggctgtgccatgctggagttcagagcaaaggttcttcaggttttcttgcgaaggaccttaacttgtcaa- tggcagagccacacccccgggacatacttggc agaggaatgcctcttcaggcacataaacatttttgcatactccatgttagtcaataaaccgtttcataag- ggttctttgaggacatctgacttcaaagggaaaaa attcataattcagacaggctctcggggcttcaccatacaacgcctttcttgtatttggttagttttatgg- gcctggagtgttgaccatgtatta 792 3844568 SHC2 NO ttcctccgcatgagcctctggcatggtccttcctccagctggccccgggctgggcagagcctcctcctgccgg- ggcccctgcccaccccctcctttgcctgg agtgagggtgttcataccaaagacggaaccatttcgcctttaaagaaaatatatccagaagcagccgctg- cctcggagccctggcccttgggtccccctctc gcctggctggttcggtctaacgccccggagagtcagggctcccaggaccctggggaggaggcggattccg- ggcctggctgggcttcctcttcccacctg aggactgggtgcacagttgtctttgaggggggacgcttaaggtgctttggggttctcaggccaggataca- tgctggcgctgaagtgcaggcagccttgagg tcacctgggatctcggggtagccaggctgctccaagacagtggatatcgaggcagtcgtgaggcccctac- tccacctgggagcaggggaaggacgtggt tgcctggcctgggctgcgcccagcagcttccccccagtcctgccctcccagctgtcgacccagatgggat- gttc 793 2810517 GPBP1 NO cagcttacactgttttgcttgcagagtcatatctttttcgtacaatggaaatcctcaagtccactttgtgcgg- tctccctctccttcccccaaaaaacaacaacaac aaaacaaaaaccaaaaaggaaaatgtagcatgttggctaaaactggagcaaagtgcactaaaacaatttc- ctgaactcacctgttgtactattcaccttttaaa ccataaattgctctttagccatttgtagtgcagtaaatgttacaggaaaagacttggcacattttcttcc- aaattttaagaggtgattttcaaaagctttattggggta tgttgtcagaccagggttttcagagttgatggaaaagagtcttgtgagaaaacttattttgataaattat- tacacacgcagaaaaactgatcacactgactggat ctgtccacgacatggaaaa 794 2377968 -- NO gtaagacacgttcccagaggcaggac 795 3020324 -- NO tatgtaatgagcatgtgcatagtgtgtgtatgtgtttgtatgtgtttgtggggggtaatggtctc 796 3133424 -- NO cctgagctggcaggtggcatcccaggctcgtgccaggacccagcagggctggtttccatgggcctgaaaaggc- ccacatcagaattccagggcatagg cgaggattact 797 3225212 RPL35 YES cttcctctttccctcggagcgggcg 798 3731955 -- NO tggaaccctcaggtgttcgcaggtgt 799 4012443 -- NO ggagtaggggtcaactggattttgccagc 800 3145052 KIAA1429 YES ttgatgaccccagaaggagttggccttaccactgccttacgtgttctctgtaatgttgcatgcccaccacctc 801 3542308 -- NO gggacggtgcacatgtgcattcacatgtgttttatggatgctacagaggaatatcagaagagaggaagagggc- cccaaacagcccctttagctctgaaa 802 2385170 -- NO atggcaggccccaatgtggcgtgcattgag 803 2617336 CTDSPL NO ggtagaactgcccatgccacaaatatttatttggaaaagtagtcattaaatgaacccactgccttaaatgtct- tgaatgttgcagtcaagtgtctgtcatgtgttga tatccacacagaattaggccctaatgagagccttagaccctcaaccatgcccctttcgttggcatcacag- ggccttatttggaagagcgggcaaagaggat ggaaatcataaaatatttcatgggaatcgaacctagggatagtgctccacttctgacgatggagtgaaga- cacttggcagacttgagccagacacttcaccta gtagttcctgaaactgtgagcaccactgcactaagccagtgcggagctgttagggacgggcccagctcct- gcaccacggacacagaatgtctggagagg gccagcaggccctctgagggttctggaatctgtgcaccttatttgaccacactccaaaattctgttttta- ttttaacccttgaatctgctttatgtacataatcaaaat atctatatctatatctatatctatatctatatatttttaatcatctacatgtaaatgaagcaatagaatt- ctaacataaggccaagaaatgagacgaatgtttggggttt atgttttttaaggtaaatacgggtattgtttttaattattaccatgtattaaattgtgggctttgaaacc- taatgaaacctgttagccacttctctgtgccatatacttcc catgttaccaaaatacccccaactctttagccaaaagagaaccctgacctcctgagtttccatgctcctt- tctgtaccaggtttaaatgtagtcttctggagaagt atttttgacattgagctctgggacaggacaccttgggtttgtggactgcagcccactatgatgttattac- ttctctggccaggcctccagtggaagtgcacagg cactcccaatgttgttaatgctctgtcttccatttgttctggaatcctacgtgttggtctgtggttccat- gcat 804 2982034 RSPH3 YES catggggaagacacacatcagtctccagaacccgaggatgagcctggtggtcctggagcaatgacagagtcac- tggaggcctctgaattcctggagcag agcatgtcacagacacgggagctgcttttagatggaggctacctacaaagaacaaca 805 2335196 -- NO gtacaggaatccagctgtgtggagcag 806 3561721 -- NO tccagctatacacccgtaacccaacagcggctcaaccctgggcgccaactaccgctgcgtcctccgccgcttt- tcg 807 2819696 -- NO gataatagtagtatggatggcagtggcat 808 3408052 -- NO catgatggttgtcttcactctcctactcccaatgattcctagaaaagaaactttaaaacatgtttctacttcc- cattctgcagtttagtaaaatgatttggttaactctt aaaactttttgtggaataatgttctgtgaattcaagtatacaaggcaggaggatcacttcaggccaggag- ttccataccagcttgggcaacatagcaagaccc cgtctctacaaaaaacaaaaagagaaaaaaaatatataatacttgaggtagttgaattgccgtgatttat- tgtcaccaatatttttaaatcttatatttattataataat acacattacatttttataactgggttataacattgattattctcacttattctagatgtgacttatttaa- ataagtttagaattatatattaaatacaattatattaaaaacat ttttgcttttatgtaaaacactatttgccatgacattttttgtcacgtaattttgtttttctttgtgttt- gaatatgatcaaatacttcccaaaattaaacttacaaatgtatat caacatattataattcaaaagctgtttttatttgggaaataaataacaatgtgtaaagaccgggaatttg- ttctcctacctaagcctgatgattaaaagacagtgta actatgcaggtgttaaacattttctatattcttacagccatctctgttcatatatccatttttaactcca- cgcccctgtaagcctttgagtttgtgatccctggtgaaga cagtgacccacattgattttttttttttttaaggtttctctctcttttttgctttttctctcgaatatag- gacc 809 3628699 HERC1 YES attcagcctcattgggtatctgccctggcttggccagaagagggtccggctacagcctggtcaggagagtctc- cagaattgttgttggtgggacggatggat ggatctctgggactgattgaagttgttgatgtgtccaccatgcaccgtcgagaattggagcattgcta 810 3350729 -- NO tgcagacgtgcacattcccagtccgtgccccagccgtcctgggtccccttacaagcccgggtctgccacttca- cccttgtttttccccatcctccgggtccac atttcatatgcccctgccctcattcccttatgattccctagctgctggttccagagtcttctgggcttac- agtctcccggc 811 3380411 -- NO aaagcaaggaaggtattgaagacacaaagtcacatgtgatgggctcaggagccagtgtgaggaagggctgctc- atacagcacagtggaggat 812 2377588 -- NO cccatagagctcctaaccagatgcaacagtgactgcgtcaccattccccacttttcccaactacgcagtgaca- aacctaccagctttacc 813 3219836 -- NO tgggagccgtggatgaaattgtgctc 814 2737650 BANK1 YES catcatgaaagcaggaagacatacgggcagagtgcagatg 815 2843633 -- NO aggctcgccttctcaatagcgtgtatttggatgagatgagtttcactgtaaagagaaaaagatgttaaaacct- cattgtctaaggcccctcatctgagaagtctt gtctgaccctctagcccagcaggaccaaggtgtggtgcctggtcccagcctgtcctctgctcccctgggc- tgcagttggcccagttgcctgcctccattagat acggagttgctctggggctgagatgcccatctcaagtgcattctgtcggaagggttctctgctggaaggc-

ctttggttttagttgggattccatgagctttagcc caaaggtggcctcccatactagcatattt 816 3478420 -- NO ccactgtccacagaccatctggggccctggagggagcgggctgggccagggaggaacaactgggaaggggcag- ggaagaatcactgaacatcagtgt gaaggtggcctga 817 2749415 TMEM144 NO agcttttcaagacacttcctgcatctctgacctgttgcacctctgttatcaggcacctctgttatcaagc 818 2921363 -- NO tgacgcgggtcttacctgggctaaattcaaggtgctggcaggaatgcattcctttatggaggttttggggtag- ggggcaaatccatttccagtttatttagttgtt ggcagaattcagttctttgcagttaaaggatcaaagtctcctttccttgttgtctgttagctgagggtct- ttactagcttctgaaggctgccttcattccttggctcat gatccccttttcttcagagcctgcaatagtgggtgaagtccctctcccattttgaatcattcctgttaca- ctatcatccctctctctgacctacccttctgtcttccatt tccactgttaaatgtctatttgattactctgggcccactt 819 2703246 KPNA4 YES tagttttgaactgtgatgctctttcacac 820 3226615 WDR34 NO gctcgcagcctttcttcggagagtgg 821 3373866 SLC43A3 YES attactttaaggatctgtgtggaccagatgctgggccgattggcaatgccacagggca 822 2852746 AMACR NO ctggtagcaagttctggatcttatacccaacacacagcaa 823 3023100 -- NO ggctcctatccctacatttcaaatagcatttctctcacaattgattatgtattaaggcttgtcaacgaaaagg- aaacttttttctctcagaatttctagaacttttttcttt aaaaagttttttattctgtagccagaaaaatttaaagtttgtgctgggttgctttggttatagaactaat- gaagcttgagtaatagtttcagacattctcagggtttttc ttctgcagccagattttacacttctattatctcagctgtcttataaatgtattccctccatcacacaata- taattagaatgtattgatgaacagatgtaacttcatcact agagagacgttaaataaattatgtgttggtatcatgacttttatcaaatcatgaaggatgccatcacttt- tatgtgatagtccattggtatagtactaaagtttgtaag taaagaatgtcagatagataacaagataacttcattttcgagatctcataacctgggcc 824 3431525 ATP2A2 NO tggtaccatccagttaagcccgtgacaaaaatggaaatttctaaatagcccaagtctccagggcaattgggaa- cagctttgaacccactaagatggggtctg ctatgccaaaacatagatacagaattcacagtttgtcctgcattaggacattctcttcaactttgccact- gtagaaagtggaggtaggtcagcggatggtgcca cattaacagccgccttactgaagtgtagtcca 825 3695469 -- NO tttatcctgatggaaagagtccagtagagaggaagagattgatgatgtaggagagagga 826 3761535 HOXB13 NO ctgccaccgccactaacggagatggccctggtagagacctttgggggtctggaacctctggactccccatgct- ctaactcccacactctgctatcagaaact taaacttgaggattttctctgtttttcactcgcaataaattcaga 827 3823884 NWD1 YES actgcagagccggtattccatatcctgggagatgcctctgatccttggatgtgcatggccgtgctggcctccc- aggccacactgctgacagtgtccagggat ggtgtggtcagtctgtggagctcagctacgggaaaacttcaggggaagcaacatatgtccagcatcaaag- aagaaacacctacctgtgccgtctcagtcca gaagc 828 2475018 FOSL2 NO ctcagctctcacaggggtaatcatctcaagtggtatttgtagccaagtgggagctattttcttttttgtgcat- atagatatttcttaaatgaagctgctttcttgtctttt atttctaaaagcccccttataccccactttgtgcagcaaagatccccgtgcaggtcacagcctgatttgt- ggccaggctggacaaattcctgaggcacaactt ggcttcagttcagatttcaagctgtgttggtgttgggaccagcagaaggcaaacgtccagccaacacaca- ggactgtaagaggactctgagctacgtgccc tgtgaagacccccaggctttgtcataggaggtcgttcagcttccccaaagtcagaggtgatttgatttgg- ggaagactgaatattcacacctaagtcgtgagc atatcctgagttttacttccttatggcttgccctccaagttctctctctcatacacacacacacccttgc- tccagaatcaccagacacctccatggctccagctatg ggaacagctgcattggggctgcctttctgtttggcttaggaacttctgtgcttcttgtggctccactcgc- gaggcagctcggaggtgtggactccgattgggct gcaggcagctctgggacggcacagggcgggcgctctgatcagctcgtgtaaaacacaccgtcttcttggc- ctcctggccagtctttctgcgaatagtcctct ccctggccagttgaatgggggaagctgctggcacaggaaggagaggcgatcccggctgaggcttaggaaa- ttgctggagccggctccaagcagataatt cactggggaggttttcagagtcaaacatcattctgcctgtgttgggggccaggtgtgtcacacaagcatc- tcaaagtcaaaagccatctggggctgctgcttc tgtttctcaggctctggggaaaggaatctccctctcctctcacttgattccaagtgtggttgaattgtct- ggagcactgggactttttttc 829 2987324 -- NO gttggtgcccaacatatgcctgcca 830 3379421 SUV420H1 YES cgcctttccttcgaggagctcaaggcattt 831 3109159 -- NO cattcagcactctcacgggatggacagagcagtgttcatgcag 832 2480318 -- NO ctctgacgcacttgaggggttggctc 833 2841516 C5orf41 NO gcagggatctagacgtcaggccaactgagagctgacagggaagagagagctagctagtatagacatagacatg- agaatcagctcagctgctgtaggaga aagtcactgacagacagtagcatccaaggcatccagcgttatatgacccacgaaaacccccaaaattaaa- tatacacaataaaaggtcaaatgtttttcttga acaaaagtatatttatattgaaaacaatcaggtgaagagtagaccctaatcgccagtattt 834 3738805 FLJ35767 YES ggagcttcttacctgctcacactgg 835 2771466 -- NO aaaagagagcaatcctgcaagccaatcccgactctgaaaatcatcacta 836 3322962 -- NO tggtggtgatgcttatagtggagagcctctaccttgctgcagctc 837 3906050 -- NO tagatctccaaaatgacctctcacca 838 3119642 -- NO ccagagaaagccgctgacagggaggagaggccccagcccctattacaaacccagccatcaa 839 3125570 -- NO ccccaaaaccatctgcaacagccag 840 3933835 -- NO ctgatggaccttctggccgcttctatgtttcttctctgattg 841 2802644 -- NO gggatcacttgccacctgggatgtt 842 2854122 -- NO aagttctgtgttagatagtcaagtagggtgactgtagttagcatccatgtattatatatttcaaggtagctag- aagacttgaaatgttcccaacacagaaatgata atactcatgagataatggata 843 3147610 AZIN1 YES gcaagagttgggtgtacctccagaaaacattatttacataagtccttgcaagcaagtgtctcagataaagtat- gcagcaaaagttggagtgaatatcctgacat gtgacaatgaaattgaattgaagaaaattgcacgtaatcaccc 844 3398488 SNX19 YES gggtgaacaaatgccggctgagctggg 845 3629947 -- NO gaccagctctgatgggcaacccaaactcaagaagtgtaacttttctgcagaacccttcagaacttaaaagatc- actgatgtaaggtcactagctggcacctctt cttataattacaattaaatgggcaataacttacccttacataatgacaactactattaaagagaaatcat- ggcatttgagaacaatgacataagattaaatcaagg caccatggctaactattcagga 846 3677823 CREBBP YES ttttgtgtgcgacaactgcttgaagaaaactgg 847 3101370 -- NO taggtgccctgaaagttattgttgctttttttgttttttttttttcagtttgtgcgtgtcacttgaatcagaa- accaaacacatgtaaaaaaatatcatcctcaatgcccc ccattaactctctctccagaaggtgacaatgttagtgaactcaagactctcactgatgatggtattttac- aatgaaaacacaaggaaaccctttgaggtccaattt tcacatcatattctccaaatagtaaaatagcagctctacatgttgatgaaaagaaatttcaatttcttcc- tatttgtttttactcatatcaacattaatatgtatctggatt tattaatttccaaaaagaaaattttagttaccaaatatttcagaaatttaataaagcattacatatatgt- aattagcacttatctaccaaaaaaacatatgtgtatgtatt tatttatcttaccttcactgaagttcttttttctggctggacatgagaaacaggattaagtgatcaatgc- tggctttatttcttcataagcagtaatttgggtctttttcat tcaacacaacgcagcattttcataataaattcacaaaagacaatacaaagaaacacctactgaatagaac- tctgtcgagcaattcatgttttaaagttggactct ataccaaactggcattatggtattataggcatttgatttttgttttcttattttcagtttgtcagtttct- ttactaccattatttttttctagccggagataacgtataatca 848 2977512 -- NO gccaagattagcatatgtgagtggcaca 849 2329726 -- NO caagcacctcggtatagcattattactgaaaccacttaattcccagctttttgagttttttaaaaaaacccac- tgcactaagattcacaattcattgctacatacaaa ttaaagctagtaagaacacactaacgtcacaagtttctcattctaaagt 850 3626942 -- NO tgcatgctcacagtaacacgtatactaaaat 851 3823576 RAB8A NO gcccacggccaccagaatgcaattgagaaatcgtttattttagtaactgtctgatctttttcaactttggaga- tggaataagttaaaaatttgctatttttcctgtaac atctgctgaacgggcccacccacacgttgtatattcagagagagagagggagtcaaggtgtgaccgtcga- ccacagccagtgtcaggcctctgcctctgg gcctttgctttgtggcctcactgcaacacaaagctccaccaggaggctggttcacgtcccctaccacgga- agcgaggtcccagaaggccagcggtggttc caggagcaacagctcccaaaccctgagcaaggcaaccgatcgccaggaccaggaagcatcacccaggaga- tttggcgcccacttc 852 3837475 GLTSCR2 YES cggagcttcctacaatccatcctttgaagaccac 853 2802804 -- NO tcgagtactatgtcttttgtggcactgaaaccttataacactatgatagctctgcttccacagcagtgaaaac- cgaaagagccgggctgggcacctgcctcttt gaggtggaactcgggtcag 854 3410550 -- NO atatctcgtctaacccctaccattgtgcctggccctttgaaatgtgtttcttgctgacgtgcttgtttctcct 855 2808525 -- NO aaacagagtagcagttcagcccttatttgccttcaaaaaaagaaaagtacaaagtgttctctaattctggctt- ttagaaagttctaggaagttaaatgaacactttt ttttcactatgaattatatgagtgaattcatcagaacggctgcttctaagaaggattttggtggttttag- aaaggtaggtgtttattcctttgcctgggaagcctcac cagagatgttgactctacaacccatctcattcgttagtttttgtggacagcagttgcctcatcgggaatt- tttttttttcacttccttaccatgtttcccttcggatggat agactagcc 856 3484743 -- NO atttacactttaacaacttgctgggaatttaaacaacttgctgggaacatcctttgtgaggcactgtagcctt- tttttatttgaaactacttaaactccaagacaggc tcactaactctttttcaagtgcaacaacaaatgtgttagctgaaaatagctaatttaatgattatttgtg- acacagacacgattatgtgagccaagaga 857 3765643 INTS2 NO ccgaaggattttgcagtcctctgtcagtaacttccattgattaggcagacatattcaggtaaaccctaatcat- taaaaaaaaattatcaatgtagaaagtaattcc cttttttctctctgagatatacctcaatcacacacttccccacccccacttgaaacagacctcttcactt- gtgttttttttttttttttcctgaggtggagtcttcccctgtt gcccaggctggagtgcagtgggatgatcttggctcactgcaacttctgccacctgggttcaagggattct- cgtgcctcaacctcctgagtagctgggactgc aggcacgcgccacctgtatttttgtatttttagtaaagacgggggtttgccatgttgcccagactggttt- tgaactcctggcctcaggtgatctgcccaccttggc ctcccaaagtgctgggattacaggtgtgagccaccgcacctggccagaccgcttcacttgtaaaagaaat- taggctaataagaaggtgtagtttttgagaaat gaaatttaactttagccttttcactagtaaatagtcacatctcattttcttcctttgtaaaatggggtta- ctactggccctacctcatattctatgagaatgagtttgtag ctgtttcaaatcatgaagtgcatagtatcacatgtgatagaatatttataactttttattagatgcttaa- tgttcaattaagtaattttgatgtgaaaaataaaagtaata aaagtatcttaaaaatagcataagaattttcatatttttaaacaaggcagttttgtagtcccttaagatt- aaatacaactgctccttttttttttaaactgaggccttgcg atattttgtg 858 3810029 -- NO ctggtctcagctggactatcgctgaacagaggcgttggccgcacatccccttggaaggactctttgcttccac- attcggaacactgtcctgct 859 2658003 -- NO cttgaaatttgagcacatcccactgtattatttcactgtatggcaaaagtgaaggaggtaggcatgttctgtc- atccttaattaagctttgggctgcttattgaagta tcattttttctatagattggaacatggtttatatagcagactatcttgtccactgacattgcccagtact- gagttcc 860 2788748 -- NO atgtagtacatttatgggctgtgat 861 3242486 -- NO ctcagctacttaggcaggagaggca 862 3540024 MTHFD1 YES aggggagtggatcaaacctggggcaatagtcatcgactgtgg 863 3439941 -- NO tgttgggaagcagcaacaatcagccatacagctttcaag 864 3457676 CNPY2 YES ttgtggaggaatacgaggatgaactcattgaattcttttcccgagaggctgacaatgttaaag 865 3843592 -- NO gcctggccagttgtaactatttatcactgtctggactcataaacattttgagatgactttgggagtgcctggg- gagtttcattcagcctggtgcatatgggcagtg aaaaatatgctcatctgtgatagtagatgtggtttggttcacaaatccaggggctgggctttaaacggca- ttaggtggacagaggagggttgctacagctgag gtctcagctggtgcagcacaaaagtgaaatagggccatggctatctgaagccatatgtggttctgtgtgg- ctatggagtcattccaggagacgttcacaggat gatttgggattaccactgctattgtaaaccatggaaattctgtgttaatattggatgctatttgtatttg- tcaagcatagtctggatgcttatccacattttggtataag gccagaattgaaggcccaatatgatgtgtcactttgacatcttgtgaaagtgggacaaccttaaaaggtg- tgagtacaaatctcattcccactctgctctcttga ataatgtatcctagcctaacagcccgttttatcaaggtgataaggcagggttccaggttgttatattttg- tggtgggtttcaattccatccctaccagcagagttat

ggaaacaaaccattgcatattcccaagggaatcatgggccgttata 866 2518951 -- NO gcaaccctgcagtggtagtagtggtg 867 3187461 -- NO cctgggaatattggcgctagagaacagtgatataatttgaggtgtctacaaatgttgtctaaaaaacctctct- cctctcatcccatgtttcctctgactctactctta aaatctaggtatcactgggaagagtaacgcactaggcccacaggaccttagtattaatataaatgagctt- tagttttcaaatgtcatttttttctctataactggag aaattccattaataaaagaaccctaggggatagagggtagagggagcgagaggggagtaagggaggacac- ggacatacttaacactacctagggcacc taaccatcagaaatg 868 3730738 -- NO ggcagataaagtacccatactaaaaagatgtctttagcttggttgaaaaataattgtcagtcctaccactgtg- agttcaaagaacttaagaaaatacagaacttc aagcagagatatagaggattg 869 2898998 SLC17A4 YES gtgagaagagatacattgtgtgttc 870 3397924 RICS YES atctaaagagctggtctacctcgtgcagattgcttgtcag 871 2494772 -- NO taaatgactgtggactagtgcgcgttttttgttttcag 872 3322617 -- NO catgacccaccgtacatgcatgggcatgatctgattttttttttaattaaagttgtcacagttatcaaagtct- catta 873 3735156 -- NO taaaattgaaatgcaggttgggcac 874 2346360 -- NO gtattctctttcatgtggtcagtgtatga 875 3757401 -- NO caccagtttagcctttgagtgtgcagagctctgccctccctcccacccctcagccccaaatccaagatttcat- agccctaacacccacccaagcagcttccct cacacatgccctttgttttcttcctctcttctatggttccttagggaaaggagccttctttagggatgaa- aagctaactacagcccagtctggcctccagcagccc agggtcagctcagcctccactggaggcgagggaggagggcaaagggcatgggagaggtagggctgccctc- caggagccttccccttccctaggagcc agtcaggattggggaggaaggcagaggggtcctagggagctgtcacatagaggaaaaggggctgggagtg- gggatgacaagaagtacaaagaaaga gaaagtttggggagatggataacaagctcagctgtgtcagtgatgtggaggggaggtatggtgggggacc- agccatggccctatccaaccccaggctcc acaggccccaaattggctttgcaaatccaaacattttaaggaagtggtttagggatggaagagaaacacg- gtagaggtctgtgctgtggattttcatctaggg tggtgggaacaccagagatgtctcctctgccattgttttagttggctcctggacctcatcccagcagagg- gagggtgactgtcagcaggtcagtcccaccgc cactgtccccctcgcagtgggcctctgtgtctcaggcctggccaggctccctgcccctcagagctcctcg- tggacccgctcctcgtcctcatctgacttcagc ttgagctcgtcgactgtgatcttgccgtcctgg 876 2386080 -- NO gggcgcttttatgaggcatgagggaggcttgataggggctttgaaggcactgatggcaattggtgaagtagac- ttttatctaaagggggcagaga 877 3013608 -- NO tttgcctcttcgagcttggcagtgcgagccacaga 878 3460675 -- NO atgaacactcgcaggtggtcaggtg 879 2564601 MRPS5 NO cacagcttgggatgttaccttgccttttgt 880 2939374 SLC22A23 YES tgataatgcctggaaggtccatatcgctaagttctccttactggttggattaatctttggctacctaataact- ggatgcattg 881 3320209 -- NO ccaccatgattgtgcttgccgggag 882 3852627 LPHN1 YES gtgtaacaaccgcacccagtgcgtggtggtcgccggctcggatgcctttcctgacccctgtcctgggacctac- aagtacctggaggtgcagtacgactgtg tccc 883 3349758 -- NO aaacaggccatgtgactgaggagcaggtagcattcatattattcatatttcgagcttggtagatgtagaattt- tgcagtggaggccaggagaggatgtgagag ctgcaggacagaggcataggtttttggaggtggttgtggtgttccccgatggcaatcaacttcacggaga- gaagaggttattttctacttaggttgcctggagc cta 884 3427503 -- NO aggtccttcaggtgccattaatttttcttgttattcaacacatattattgagcctctgtaatgtcctaggctt- gttcaagatgttcagaataaagcagtggatagaac aggctttaaagccctgtactttattgcccaagtcaacgtccttagaatacaggtacctcacaactacctt- gaggcttttattatgttattttcttctgcattcaggaatt ccccagagccaataggatacaattttaaaatgtcaaaccatttttgatctcataccatttggcttcagtc- cttctttccaactgtatcattgtctatttctaaataggga tggtctacactgtaaggctgatttgctcattgcccccacaaaatttgtcttgcattttctctgttcattc- ctgcacctgaaataattttgccactgccttctcaaagcc ctcaaaccttcaatgtctgggtcaaagccgttggctcccaggaagcctgttttagaaattaaatccccaa- gttcttttatctgcattgattatttaacacctgacagt tgcaacaactaagatgatttgagcgagataatgctccacattttttaccgtgtctgtgtttgtaggtgtg- cccaactgacatactggctaagagttcagggtccca 885 3835463 -- NO gtcctggatcatcaacttggttacaacatggtgttaacatgtgggactgattgtgtttcttgttaatatttct- gtttctcccaaccacgctgaatatt 886 2809576 -- NO tcaaatctatggcttaccagagagaagaccagagcgcaatatctccgtggccttagtcctgact 887 3601075 -- NO atgggccaaagctggggcacaggaaa 888 3864620 C19orf61 YES gacttatgttttccgggcccagagcgctgaaatgaaggaacgagggggcaaccagaccagtggcatcgacttc- tttattaccca 889 3888182 CSE1L NO ggaagttctccttttgaacttgtcacgaattccatcttgtaaagg 890 3558243 RIPK3 YES cttcgggatcctaatgtgggcagtgct 891 3702633 -- NO tttactcctaagcaccagtgatgacctcgtcaagcagggtgggctgcagggagatgacagcgggtatgaaagg- gtgtga 892 3433106 -- NO tagctcaatgcaaccgacgtttctgagcccccagaatctgatccagatcccggacatataaaccacgccaaga- agacaggggctgtctctagcacattctct cgagggagtccggggccccttcccagacgcaactgcaaaaggaagggctaacgccatggcgggcccgtgg- tttattttatatccgacaaagtgcacggc agcctgaactggactggaatgaaaagacgtgtctgggacgggtctacggggacgcgctgcgggacctgtc- cggcttggcttccaagccgctaaccaacc gctggatgctctgcagttcgctggtggccgcctctttctccgcgcagagtttgggcgacaa 893 3544695 TTLL5 YES ggggcggggcgtctacctgatcaacaat 894 3219716 -- NO gtggcatctctgcttggaagtcctattcttagtctcagcttcagtacaccctcaagctatcttatttgcttct- aaaaatctcttctagtacttctgtttcagtctttgtata gttcctatctgttctttggatattaattatgtatagtcacgtatatatactgtgcagacttatttagagg- ctttttgtcatattttgcttaaacctgctactgtgcaatctta cattccagttctttcattagtatggtctttttttttcctttctcctctcttctacacttctattctactt- ttccttcttggtccctttgcgtagcatcttttgcctggccatctca gttttatcttttaagtcctttttctttgttcatcccctgcttcagtgagcttttgcttctctgaactttg- ataacaagtattactgaaccatttatttctgggtgtagaattca tccaaactgagcttttgagggaaccttattggttatctaattcattctcctggccagtacagctgtcatt- ctctgaaacatccatgacagtatctacttgaatgtttaa tggacatctcaaatgtaacgtcagagactgaattccagaccttcctccagttgtctgttcttctcatagt- c 895 3442242 ZNF384 NO aaggagaaggaataagacggcaggagg 896 3293761 -- NO accctccttaccttgtccttagatgcttaacatttttgtttggttttcttataaaaataacagatcttatgaa- ggtagaggtcagatgctgaatgagcgtctggcaaa agtgggatctgagcagctgatgcgggctgccagggccaagccaaggttgtccccaaggcctggccttgga- gggtcccccccgaccggccctgtccctg cccttgctccctgggaggggacggtggatgggtgctgctcacacccacaaggcttccctgtctagtcaca- gctctgtgatctccaggggggtctccatgatc acgtcgcgaa 897 3829701 GPI YES cccaggagaccatcacgaatgcagagacggcgaaggagtggtttctcc 898 3539958 SYNE2 YES agtgagaactacagaaggcgaggagg 899 3620286 EHD4 NO ccctatattattctatccgtcctccag 900 3621069 -- NO atgaatccacctaaaaggggcagaggca 901 2496816 -- NO ccacccatgggaagctgatgagttttgtgtattgaattcgaagagcagagaatgggggaaaaggagattcccc- cattgaaaacctagataatgagagaggc ggaaccaaaagcagactcagaacttcactgagaataatgggggtgtagtagtcaggtgagagagactgga- ctaccaaatcatcgttgctatccagtta 902 2644239 -- NO tgaagaccagtcgaaggagtgcagaccaggaaaagcgggacgttgatttggatggga 903 2832085 ZMAT2 YES tggactttcgccgaaagtgggacaaagatgaatatgagaaactcgccgagaagaggctca 904 3757844 STAT3 YES tgctgaaccctcagcaggagggcag 905 2943556 -- NO cctcatctgctcctactaccttgca 906 2459948 -- NO aaacttttctcgatacccttctgtgatgactt 907 3119958 GRINA YES ctttgtccgggagaatgtctggacctactatgtctcctatgctgtcttcttcatctctctcatcgtcctcagc- tgttgtggggacttccggcgaaagcac 908 2567115 -- NO cctgattagcatatcacagtgctctaggagtcctggaacgccttcctcttccatgtgcactgctgctgacatc- caggccattttggaacctgcaaatgtctcttccc 909 2893649 -- NO taagtcttagtaactccgtgctggatgtgcattttgcattcagcttctttatcataagggaggaacaaagact- ggggctcctgctgacatctgcagacacaaag ctgagtcggaatttgtggtcttagcttcggttcagcaccaagtgtatttataagtttgcagtcataggtt- ttgttgtccaaatcccaacaaagccctttcccacctcc accccaccccggaagttatatagggttccttgaagggacaaagcctctagaaaaagaaaagtcactgaaa- gttgtaatgtgaaaccagcaaagagaaaata catgtttggtttagttgtggtcacagtccatggtg 910 2346547 -- NO ccctgacagatctcggtctggggcacagga 911 2852745 AMACR NO ctggagcttccctggactcaacttcctaaaggcatgtgaggaaggggtagattccacaatctaatccgggtgc- catcagagtagagggagtagagaatgga tgttgggtaggccatcaataaggtccattctgcgcagtatctcaactgccgttcaacaatcgcaagagga- aggtggagcaggtttcttcatcttacagttgaga aaacagagactcagaagggcttcttagttcatgtttcccttagcgcctcagtgattttttcatggtggct- taggccaaaagaaatatctaaccattcaatttataaa taattaggtccccaacgaattaaatattatgtcctaccaacttattagctgcttgaaaaatataatacac- ataaataaaaaaatatatttttcatttctatttcattgtta atcacaactacttactaaggagatgtatgcacctattggacactgtgcaacttctcacctggaatgagat- tggacactgctgccctcattttctgctccatgttgg tgtccatatagtacttgattttttatcagatggcctggaaaacccagtctcacaaaaatatgaaattatc- agaaggattatagtgcaatcttatgttgaaagaatga actacctcactagtagttcacgtgatgtctgacagatgttgagtttcattgtgtttgtgtgttcaaattt- ttaaatattctgagatactcttgtgaggtcactctaatgc cctgggtgccttggcacagttttagaaataccagttgaaaatatttgctcaggaatatgcaactaggaag- gggcagaatcagaatttaagctttcatattctagc cttcagtcttgttcttcaaccatttttaggaactttcccataaggttatgttttccagcccaggcatgga- ggatcacttgaggccaagagttcgagaccagcctgg ggaacttggctggacctccgtttctacgaaata 912 3659213 -- NO acctccaaggttacagcactttctaagaatgtgcctatgtagcatgtctgtccccccactgcctccaccaaaa- ttctgagaacaaagacactgtagggattgaa cctgaagagtattcgctggaatggtatgctaaggtttctttcctgctgtacacctcctctgccccaacaa- ggtgctttaagttctgttttttaatttaggaaacctgtt ctgctattatagaaggccatgaaaagagaccagtgatttatctaatcataagcaaaaatagtagaaggct- attgtcttgtcacttaagttgaatgaatcccagtg attgtagttgcttcacgaaaaataaccaatttgttctacagaggtagtctgttcccagagattgaaaaaa- aaaaagatgtaggaaagtttaaataaataaaattgt ttaaattcacaatggagggccaattcacatggccctctgcattttgatgtaattctaacagttttactag- cagaatctaacaaattttgaaagtcagagcgtatgta tagatatatatacacatgcacacatttttttaatgatacgttatccacttaaaaaaaaaagtctcaagaa- tgtcataagaaactcccttaacctcaatgagcctcag gtttctaatccctaaa 913 3296517 POLR3A NO ctcatgtaacctgggaagagccataaaggggtaccccccaccccaactgccttcctggaagcatgcctgggaa- gtaagctgtaggcctgatccgagccag gaccactgggatccgtgcaaaggccaggggagggtagaattgaatcataggagtgaactccggcacctgt- tgtcttctgcgggtgacgcacactttaaatgg 914 3028090 -- NO cttggtcgtcacattctgcttttag 915 3291113 -- NO aagatctttgagttgtacttggtgtgtgctgtttttgtttgagatgcagtgaatgtgcaaatagcccagccgt- aaatagttacttaaaataatctcttggtactgggt agcagcagtagaaagttgatctgttta 916 3616816 -- NO gggccgaaactgctgccgtgcattagctctgtggaggggagtcataaattctggttgtcagcgttttccgtgg- ctttgtg 917 3842744 -- NO ctccatatattagctggggctgccataacaaaacatcatagactgggtggcttaaacaacaatttacttctca- cagttctgaagtctggaagtctgagaacagg

tcgccagcatggttaggttctcgtagggttctcttcctgttc 918 3956320 PITPNB YES tcccgagggctccttggtgtttcatgaga 919 2473315 -- NO ctgggctgccaatctcttgccttgggggcagagcctcatctctctggctactggggttagctaccttgttgga- gctggcaaagccattggtgttgacatcggg ggtgactcctgaagccgccatatacgtgctgccaatggttttgatcttggtgatcacccggaacttggga- ttgtccaggagctgaggccaggattcaggaaa gaattgtcagcagtcaagggagaggaatgacccaacccagtgacagatgtacctgtttacaaggacccca- ctaaacccaagagacactttcctatcaaagtt gttacttagtctaccgcttatctgccacatgatcctgggagaacttc 920 2659117 -- NO tgcctacatgctccttctagctttgtttccctgatgttccttgccacctgctactcctctctgagctactttt- ccaggttccacagggagaggttcagctgtccgtgg tagacatgagggtagagaatgaggtggttgggttccacttacctttctatcatcttgcagtatggatgtc- tcttgactggtaccgtgta 921 2826873 -- NO gatatttatttgggtgcatgtttcct 922 3498544 -- NO tggcgtctgatcaggaagggactctgctgcggctgtggatctgacctgggtatcagatggtgatgctttgtaa- atagtgtgcctcataggggtctgttcttagtt aaaaggagcctgcttggtgattccttttg 923 2756844 SLC26A1 YES caggccatcgcctactcattgctggccgggctgcagcccatctacagcctctatacgtccttcttcgccaacc- tcatctacttcctcatgggcacctcacggca tgtctccgtgggcatcttcagc 924 3088854 -- NO atgtgccctacccagacagtgcctg 925 3173548 PGM5 NO cgggagatgcttcactgatgccttcttgctacctgtttgtgcctcttatgactttggaaaaacaaaagatatt- ttgcttttgggggatagagggtgggtgggaaaa gaaaaaaaatccatttggttttggttttgtcctattcctccaaatgcagcagggcctttagttgtctgtt- aaagctgcactataatttggtatctacattttatcacaca aaggaacctccccttttgacaacaactgggctaggcagctgttaatcacaacatttgtgcatcacttgtg- ccaagtgagaaaatgttctaaaatcacaagaga gaacagtgccagaatgaaactgaccctaagtcccaggtgcccctgggcaggcagaaggagacactcccag- catggaggagggtttatcttttcatcctag gtcaggtctacaatgggggaaggttttattatagaactcccaacagcccacctcactcctgccacccacc- cgatggccctgcctcccccatcccatccccaa catccctgtaccaccttctctcacatcttctaaagctttgtacaaatcacaatggtgcacttccaacaaa- atatatcaataggtgttttcctctcttattttgtaaatag tattattttagctattaagctggataccttctttcaaattcagccattcagttgtaaagttgggaagaag- tttcttgacaagactctgcaattaaatgcttaaaatttgg aggggatccttccttgattacatcaagtatgttggtacatgggtttatacaagttcctcttgagaaggca- aaaagaccaccatgtgtgagagctctttgacttgg ccaataggggcctatcttaatgcacttgtttggacacatttctgatcttatttgtaaaggctgcaaaagg- agaggatgaaatgctgtaaaagtaggaaatgaagt ggaagctggaagaaaatgtaattggtggtacagctatgggccagatggtggaggggagggtggggacccc- tgc 926 3200057 BNC2 YES tccctcccaaccagtcccatcattccaaccagtggtaccatagagcagcaccc 927 2974443 MOXD1 YES ggccatgagagtctggtgcaccacatcctgctctatcagtgcagcaacaactttaacgacagcgttctggagt- ccggccacgagtgctatcacc 928 2385905 -- NO tctaaaaggcgtggaaacatttataagaaataccaattatgcagtgttggtgtcagtgtggacttaactgccg- agactgacttattgccag 929 3639566 -- NO acaggttatttctatggacaggctcttgacagaaactctgaacatggatattactgtccccttcattcaaatg- aggctgaactgaggctcataagtatttaactctc acacctagttaacacagtaagatttgaaaccagatatatatgaatccacgaagtcttatctg 930 3200565 -- NO tggcatttcatgaggggaggcttatctgtgg 931 3083781 MCPH1 NO atgtagtggcctatgttgaagtgtggtcatccaatggaacagaaaattattcaaagacatttacaacacagct- tgtggatatgggggcaa 932 3829376 -- NO atggccgtcgtcaggagcattgtgga 933 2359017 -- NO gtaaccgggggatcttgcttgtcagtgcctggac 934 3180982 HABP4 NO ggggagacttttccagctgggccaagggagtcagactctaagaacaatagatgttgcttttcccgtgtcatgt- aaatttgttgcacttttttgggctgagctgtta gaggggcttctccagaggctcgagagcaggccatttcccaagaagatgaagaatggtgactgtgttttta- ttgaaggaatttcaaatgaagaataatgtttaaa atgtgtatatagagatagtatagactcctccgcggaagcatggagggaaaggaggttgtaaaatagactc- catggagactcttaggaagcagtagattcccg ggggctgtgcctttagcgttagaggaaacacatagagctggaactgttaatggaaagcagtcacagctga- gttttcggagaccaa 935 3915249 -- NO ccaagctgtagatcttcccaagatatttttcaggaacgaagcatgtaaacttacatgagtgaaagacagtggt- aaaaaaaaaaaaaaacagtctattttgggct ttggctcctacctaaatctagcttgtt 936 3263765 -- NO tgcagagtcctacagctggttcaaggcagcatcaggctcagaacccctttctctcagctctctgttgtgatta- tttcaggaccttgttctgttttccacatggcctc taatctagacacctgacctggtgggagtaacctttca 937 3303272 ERLIN1 YES ggagctcaaaaagtaccaggccattgcttctaacagtaagatctattttggcagcaacatccctaacatgttc- gtggactcctca 938 2683681 -- NO ggtgacccaggcacgatagctaagaaggcaaagtcgcttgttctattagctgtttaggcatctttgcagccat- ccttgatttggagtttttgatcttgatctaattct atccctcaaaaccagcccttacaatctcacgtgcccacctcttccatgacagtccttgggcctagaggga- gggtgattgtatagttttagcagcagggcatttg cagtgaaaaacagattgggcccagtgggatgccaaatgagagagggtcgcatct 939 2683865 ROBO1 YES tggtgtgtggcttcatacatttggggaccctatttccactccctcctcttggcatgagactgtatacaggatc- cacccgag 940 3781116 -- NO ggcagctgccctgtaatgttctaccagtacttcagactcaacatgcacgaagattaa 941 3050281 -- NO atgctgcccttcgatgaccatagtgaatgttccacagagtgtactacgagccacaaacaccagggagagaacc- ccagcatcagtggagtagaaacaaaaa ggtgttctgtgtttcgcacttgggtcctg 942 3903591 -- NO atcggcatagcctagatgggtcttctgtttcagggtctctcacaggaggtagtcaaggtgtcagccagggctg- gtgtctcatcttagcgcttggctggggaat aatctgtttccaaactaacttggttggtgacagaattctcttcttgaagggatgttgaattgaagggctt- ggtttctcactggctgatggctggaggttgctctgaa ttcctttccatgtagcttcttcaacatcacaaagctgagaaaggaatagcaagtctcctaggaagatgga- aatcacaattttttataatcatggagtggcatccta tcacattttccatagtccgttagttagaagcaaatcaccaggccagtccatactcaggagga 943 3115066 -- NO gtctaggggttacaggatcatcatctaagttctgcttctgcctggacttgctgcgtaatttgaatgagtggct- aaacctgactctttctcctcttg 944 2509773 MBD5 YES cactaacagaaggtttggaagcctacagccgtgtccggaaaaggaacaga 945 2322410 NECAP2 NO ttctctttggtggtttctaaagtgcct 946 2837342 CYFIP2 YES ttttgtgcggactgccattcctttcacccaagaaccacaacgagacaaacctgccaacgtccagccttattac- ctctatggatcc 947 2936910 -- NO ttaaaggtgtagagtaagaagaatcaataccgtgtgttggatattaagcaattggtaattaatcttgcttcct- ttatcttgacaagatgtgctttttcacttac 948 3958553 SYN3 YES atccttcaagccagacttcatcctggtccgccagcatgcctacagcatggccctgggggaagactaccgcagc- ctggtcatcggcctgcagtatggaggg ctgcctgctgtcaactctctctactccgtc 949 2901722 -- NO acagtaatggaagacgggagttgcagtgctcagtcatggaattcctccta 950 3092902 NRG1 YES ccaaatgagtttactggtgatcgctgccaaaactacgtaa 951 2437102 KRTCAP2 NO tgccacgtgctcagaaattcacagcagatgcaatctcatgtaaaaccctcatgtggtaaaacaaagatctatc- atggttgcccttaatcttttctcttttttttttttttt tttttttgagacaaggctttactctgtcgcctaggctggagtgcagggatgtgatcactgaagccttgac- ctggtctcaagcaatcttccctcctcagtcttacca gtagctgggactaccagtgagtgccaccacacccagctactgttttaagtttttgtagagatggggtttc- accacattgcccaggctggtctcgaactcctggg ctcaagtgatcctcctatttcagcctcccagagtgctggaattacaggtgtgagccactgtgcctggctg- ccctcatttctttgcccccctctaggacttgctttct ccgcatagcccttttgcaggcttcagagttctttccatccagtagccccgggacttctctctgttaggtt- ttg 952 2657991 CCDC50 YES tatgccgagattttgctgtcctggag 953 2520359 -- NO ctttgagcgatgaaaacagtttttatctttttagcaaagttgtagttaggatcttctgtctgtttttaggggt- ctccactggtattaaaggcctga 954 2592274 STAT1 NO gctgaggtttagctgtcagttctttttgccctttgggaattcggcatggtttcattttactgcactagccaag- agactttacttttaagaagtattaaaattctaaaatt ctattaatctctcattaatagtatttaatataaagattcttaaaattactgacgttatgaattggtttga- tgc 955 2681309 -- NO atcttctaagtgtccatgcagcttgaatcattgcacacagtcttctatgagttatgaaaataaataaaacccc- ctcttttccccattttatggttgtgaaactgacac agataacacaaaagggtagattagggaaagccatatcccctctgccacccacctccaatactgatccagc- tttcctggatcaggctagtagggcgttgaggc ttcttactagaa 956 2961267 COL12A1 YES ttggaatccatctcctagtccagtgactggctacaaagtcatcctcacaccaatgactgcaggaagccgacag- cacgctctgagtgtggggcctcagacaa ccacgctcagtgttcgcgacctctcagcagacacagaataccagatcagtgtttccgccatgaa 957 2854242 RICTOR NO ggctgcatcctattaccacaatggggtgtgctataactgctggtattagagagggaactttggccctttcacg- tttttcttaatgtttgtaacactacttcagaggtt tataacctcaaagcagaagaagagcctcaacaacccgggacttataagttatttttatgttactagactt- gcataaagattcttgttttccaactcttcattttgttgc aatgtgttattacaggatatatgaaccaattaaggtttttcactacagttcttgaataaaatttaaaaat- cattttttattttaattaaaaatatttcccatttatagaatgc atatatttgcaatggacttccactttcatcaactttccatctcatcgctttaaacaggaacttgaacaag- cactgttagtttagacctaaaggataggaaagcatta aataatactttggatctcctgaggaaaagataagtttgcttgcaatttacacattccatggggaaagaag- agccatatttccttaaaaaaaacattaataaagctt gttattgagaaaaattgtagtgaaaagccttaagtaccaaattttaaagcagcagtaacttaatttttat- atcagtgtttttgttttgcacaaactaaatgcagtggta ggtgggtttatgagtatattaattgcctttatccatttgtgaagttaagttgatgagggcaaggtttttg- tttgtttaatttgtatatgtctaaaggtatttggaacttttta caggaattaaacatatatgcaaatttgtatataaaaatagcatggccatcatttgaatgcttgtaaatga- aaggattatcttttttgagatctatatataaatagaaat agaaaatccagctggactgattaggattcttttttaattcatttgtgtataacatttttattacaattac- acatcagttttgacacagtcatagcaacattaatattttccc atgatgcagatcctttttgtaatgggcttgttctttga 958 2957263 -- NO tggggaggcacataacagttttttattctgggaagagccagttccccactcaacatattcaataggcacagag- accaggggaccacggaaagctccagtga cccccgacccccgccaactcttcctaacaacatttgactccttgccctcctccgttggaactgtgcttcc- tggaaggaaagtgattgaagaagaagagatgta gttctgtaaaaggcataaaaacagcttgtttttttaaaaaaataatatttttctgttatgatgcaaattt- tttcatgactcttctttctctcactctccacagtcatttcatc ggcaggtcctgccagctctgcctcccaaacacattgagactgtctgctgctttctgcctgcaccaccaac- cctagtctagtgacctttgaccaggggaga 959 3429874 OCC-1 NO aacagaagaatccgtaacagaagatgaca 960 3766915 -- NO ctcctccattgaagcagattgattaaaacagcttaggaaagggcaaacttggatcacgagcagtggatttttt- tcatatctgatagtgaatttaactttttcatttct ggcgaaattaaagagatctgtgaccaaaagtggtcaagcactggagtctga 961 2691040 -- NO cgcactggcattggaacataataaactaaaattaaaatgtttctttactgtgcctcaccattgcacaatcaaa- aaaaatttttttgcatacactgtggtgaaataatt tttaaaacttggacttgctactgtgaagactgatgtttaaagtttataactgtataaacattttctatgt- ccccccccacaccatggatttcttataacattggatatatt tttccttgctggactattctcttttggattga 962 2824389 DCP2 NO agtgcactgctttcttacaggaagacaactcagaacacacagccataatctgctttggtgtcagtcacatcac- agtggttatacatttgtcctgaatggtgattca ttcctttccatctaacttccttgtgacaaatagcatttactattgaaatagtcttaaaatagggaaaaga- gtgaaagttactcttatgcatgggagtgggcttaaag ggttgacttccaccagctgagtacaaacaagtgtaaagaaaaactatgataaagtatggaggtcttgaga- attgttcataatgaaatctttaatctgggttatca gagtaatgaaatcaccaataaaaacattccatttatcttggatcttctgtggttagcagaggagtatggt- ctagctatgttagcagcttgaaggcacaacgtaaa aggaatgagctttcacaaggtgcttacgttagctgggtagtattggtcaaaggtactctgaagagtgaat- gcagaaatcagttggctgtgtttgtaatcttgtcc cacatggaccctaacctttagtagacttcagtcttttagtccagtagaagacaatggccctgaatatgtg-

ttttctgctttttggtggaaggtttcctgcaggtggtt gggtggtttttgggttattggctactgttcgttcagtgccatttgaagacctgttgtttcttaatccttt- ttcttggtgtgactggccaggaaaaagtccattgagtcct ttttttctccctggtgtcttaccccttctgtagaataatccatattttaaaatttgtttcacatcattta- tagcaaacctgccacagacttgcaagcagtgattttatctttc cttcctgagaaggtgatctcacttttgatgtttgggtcacctgtggacacctgtgctcttttgagtctca- aggcttatagctttcacattggcttgggaacaacaga cttgtgtgtggttctagagtgaaatgggcagtgttctgctggtcctcagtctttgagag 963 4054485 GABRD NO ctctgcaggatcgggatcagagcgtgggaggaggtgggggtggacgtccatccggtgaacagtga 964 2871027 EPB41L4A YES cccggcctgatcagaatgtgacaagaagtcgaagcaagacttaccctaagcgaatagcacaaacacagccagc- tg 965 3468170 -- NO gctgagcccataacctgcgtcttctgctctagcctcttgtctgtctcattcctcctctgcatggattgtctct- atttggaaggtccgtggtttttatgtgtaaaatgaa agctgccgtgttccctttccaacaccaagtctagttctctagctcccattctatcagtgtcatacctccc- agcttaa 966 2739471 ENPEP YES gatactgcattcaaacgaaacatgtggccattctctgtgcggtggtggtgggtgtaggattaatagtgggact- tgccgtgggct 967 3725508 -- NO ccagtgctttgcactgtagctgctcaataa 968 3946498 MCHR1 YES ttcgcggtcgtgaagaagtccaagctgcactggtgcaacaacgtccccgacatcttcatcatcaacctctcgg- tagtagatctcctctttctcctgggcatgcc cttcatgatccaccagctcatgggcaatggggtgtggcactttggggagaccatgtgcaccctcatcacg- gccatggatgccaatagtcagttcaccagcac ctacatcctgaccgccatggccattgaccgctacctggccactgtccaccccatctcttccacgaagttc- cggaagccctctgtggccaccctggtgatctgc ctcctgtgggccctctccttcatcagcatcacccctgtgtggctgtatgccagactcatccccttcccag- gaggtgcagtgggctgcggcatacgcctgccc aacccagacactgacctctactggttcaccctgtaccagtttttcctggcctttgccctgccttttgtgg- tcatcacagccgcatacgtgaggatcctgcagcgc atgacgtcctcagtggcccccgcctcccagcgcagcatccggctgcggacaaagagggtgacccgcacag- ccatcgccatctgtctggtcttctttgtgtg ctgggcaccctactatgtgctacagctgacccagttgtccatcagccgcccgaccctcacctttgtctac- ttatacaatgcggccatcagcttgggctatgcca acagctgcctcaacccctttgtgtacatcgtgctctgtgagacgttccgcaaa 969 2818169 -- NO agacacagacgggtggacccaagcattgagggc 970 3092610 UBXN8 YES ttttgctttgtggccggattttgctactgcttgctcttctta 971 2560754 -- NO gcccgctatctgcatctgccttttggactccttgggggaaataaaacaatcgtgtacagttgggaggctcttc- gttttcaccatcagttgactccatcagt 972 3850324 -- NO gagttcagggagacgccagacaattgcagcagtttgtagagttatgtgggtcaggctaggattagttttgctg- caggaataagcaatccccccaaatcttaat caaggtttacctaaaatcggccgagcaca 973 3209807 -- NO cttctctgaaaagaccagcggccctatgactatc 974 2639722 KALRN NO ccttcttctctactgggtgcaattcgaggttgctgagcttctctccaaagtctaaaatggtggggcagtaggg- acctgtgagaggcccaatggcccaatgtact tcccccagatcccactcagaacagcaggtacgcccaggctcctgctgccctagaggtctgcaacatgagt- gaagaggttaattagagggacacacttatct ctgaagtttttctccaggctgaacatttctattatcagtggcccctaatctggaaaaacccatcattcta- atctagcttgtatccccacatcatgagaaagaggga agaagaagaagggatgatgtgtggtagagaagatgagggttaactttagcctttcccaaacactggcaac- aaccacttcctcaacaatttttctatttgcttcag cctactcagattttttcaggtttttctagctcctccataacctcactccctcccgaggtctctggttcaa- agaccaccctaccagcccctatttgcttcaggttatcc tgttgagggtgggtgggaagagtgagaagatataaatgaaaaactggccacatgttgataattgttgaaa- ctagatgatggtacgtggacattcattataccat tctccccacttctgtatttgtttgcaatttttcataataaaaaagttttaaaagtcctccagtttccaac- acactcaagagagagccccaaccccaaacacagagtt tcatggaaaccccacaccaaggcaagaggcagagatgatgattccatttcatatatacactcattttcta- actttttttaaaggcccactgctttattttcaatagat taaacctgatttctgagaggtcctgaagttgggcttatttccctggc 975 2972483 -- NO gtgatgactatgggccaggacaaca 976 2518314 ITGA4 YES gcagttggtgcttttcggtctgattctgctg 977 3680796 -- NO tgtctgcttcaacctcacacttctctcag 978 2329274 -- NO ctgtgggaaggactcttctaggttttggactctctaattcttctgctgaacccagtgactgtgtaaacatcca- gaggcccaccccacccaaagaatgtcagactg 979 3379673 CPT1A YES ttcaggcagcaagagccggcaacgccatccatgccatcctgctttacaggcgcaaactggaccggga 980 3549257 -- NO tgagtcctccattccaaactctcct 981 2360474 FLAD1 YES gacatctagggcctctgaactttctccggggcgcagcgtgacggctggcatcatcattgttggaga 982 2584988 SCN3A YES aaaataagatgcgggagtgtttccaaa 983 3630231 LCTL YES tcacatgcaaatggttacggagatcgtggtacccactgtctgctccctctgtgtcctcatcactgctgttcta- ctaatgctcctcctgagg 984 3801606 -- NO ctggtgccagggctcctctcactgccctacacttgcagggaggtggacttccctccc 985 2476381 -- NO agcatcacatattcaggggaccttgaaaagtttggtgtgcctgagcatagtgtagctggaaggtagtggtggg- agatgagcctggagaggaaatcagggg ctagaagataaacaggaatatatcacagagttacttaccttaaaagtaatgttgagccactgaaaggttt- tcagcagctctcatcaggtttgcattatagaaaga tggtcttcaggtgtagttgaatggttggaggggaagttggaacaagaccaaactaccatggaagagactt- tcatctgttttgtctcagcagatagagctgtatat gtcttctccctgtcctactgttttgggggactgagattttggtactcatcagcactcttgctctcatatt- atgga 986 2522188 LOC26010 NO ggtgctgacccaattcgctgccaaaagagtgtcaatcagaatatacaaatcccgtatggttgtgtcatcctct- cttaatcatttttactaattctaataatcagctct agcttgcttcataattttcatggctttgcttgatctgttgatgctttctctcatcaagactttgcagc 987 2673516 UQCRC1 YES atgccagtgtggtacgtgagatctgctccaagtacatctatgac 988 3659195 -- NO gaagaagcagtgcatctgggtggca 989 2652475 -- NO tctgtccctctgctagttagttctgtacagttatccccacagtcctcttcctaaagtagacattactttcttg- ttcaggtctagagttggttgccttcgcatgtagttaa agttctgtagcatggtgtataatatccataacactcaaccctgcttacctctcaagaggcacctttacct- gtcaccccacagtctatgtgttaaatttctgttcccta gataccttgggcctctttctaaatacacactttcatgtccattatttccccctgtctggaatactctaga- gcctttcattgacaattcacttgttctttttggtgcccctc ctcaatgtgacccttttagaaccttcatcacagaaatagttgttctgttttttcagcatctgtgattctt- tccctccctgtcatagaataaaatgtgtatttatagtcatc accaagaactcatattgcctcatggggattgtatctcagcatc 990 3198107 -- NO atgaagcagcacaggtacgaggtgcaag 991 2994022 -- NO gtagattcgatgggcccgaggctcag 992 3548367 -- NO tcctgttttctgcattagctgtttgcatgtatttagtaggttagaggtgggaactagagatcagagaattgtt- tatggcagcagagttagcagtaacttgagaggg catagctaagtcaaagacctact 993 2440185 COPA YES ccaaaaaggtacaggtgcccaactgtgatgagatcttctatgctggcacaggcaatctcctgcttcgagatgc- ggactctatcacactctttgacgtacagca gaagc 994 3480073 -- NO atggggcttatccttactcgcagtcacctaaaag 995 3513910 KPNA3 YES ggtccaattgagtgctgtccaggca 996 3978139 -- NO gaaggcctcggcaaaggactgtgct 997 2540091 -- NO cagctccagggtgaaatggtgctag 998 2896688 -- NO tcccgagggctgatcactggaaacagggcaacctctggtgacctggtttttcatcaccagccagggcagaaga- agtcaaagtgtgctcaagggctttgcac gctgctccctagaactgg 999 3022504 -- NO actgtcttggtgttggtcaggattaatataagggagtg 1000 3104044 -- NO atggcctgaaagctttaggtggtgcaacacagggtgaa 1001 3939535 SLC2A11 NO caatcaatggtgagcgtggtattccaggctaaaggtaattaactgacagaaaatcagtaacaacataattaca- ggctggttgtggcagctcatgactgtaatc ccagcactttgggaggccaaggtgggaggatcaattgaggccagagtttgaaaccagcctaggtaacata- gtgagaccccctatctctacaaaaaattttaa acattagctgggcatggtggtatgtgctaacagctctagctactcaggaggctgaggcagcaggatcact- tgagtccaagagttcaaggtagcagtaagct acaatcacaccactgcatgccagactgggtgacagagggagacttcatctctttaaaacataataataat- aattacagactcaggaaatgcagtgaaagaaa aatacaggttggccaggtgaggtggctgatgcctgtaatcccagcactttgggaggccaagatgggaaga- ttgctttgagaccagaagtttgagaccagcc tgggccacatagtaagatcctgtttctaccaaaaaaaaaaaaaaaaaaaattagctgggtgtggtggtac- atgcctgtggtcccagctactcaggaggctga aatgggaggatcacttgagcctgggaggtcgaggctgcagtgagtcctaattgagccactgcactccagc- ctggacaacagaaagagaccatgtttcaaa aaaaataaatacaggttgtagtgggtatgggtatgcataccaggaggcccgacctcgtctgagaggggag- tggtcagaaaagaattttctgaggaattgatg tttttaatcaactttattgaggtataatttatacataaccaactgcatccattttaagtatatatttggc- gagttttgagttctaagtatagttttggtgagtgtatacactt gggaaacaccaccgtgatcaagatggaacctttaccctaccccaaggcacccacatgcccatttgctatc- agtaacccaccccagtcccagacctggg 1002 2420794 -- NO tagatctccacatgataacctgttgaactttttgagtatctgttgatcaagaaaataaagtcaaaagctacaa- ttaattagtaatgtgctcaaaataaatttgtatttt ataaatcataacatcttttccatgttactctgtctatatggagttcttaataccacacatttgcttaggg- agatggaattagcaactagtctgtgctaccctgtatttttt ttttaaccatgtagttggattttttaaaatacaataaaagagttcacttttccaggtttgacaacatttt- tatgaattggaaattttctgtggctacagatactattaacat tttggaaaggtgtaaagaacattgttttaatgtaaggctcttctctaacctccctcccctctccaaattc- tccataatatgaagtaggaagatatgtatttttctgttg ccattaaaatgttctggccatcgtgggagtggggatggggagggcggggatgggaattagaacttactag- aataaaattccaaatagaggtttggggaaac ctacttgtgagtgctttttaacctcaaaataaggatttggggtgggtggagaaggtgatggggcagaaga- agttgtttttggaggagagaaagcagattgaaa ggaaaaggacagctgatagccacttaaataatgtcatcgttagagtgatacctattttttgtaaaaagaa- aacaatatgctccattcttacaaagcattgattgtat tttaatatatacaatgtaaatactatcatgcagtggtgtccaagggagagaatacagtcatgagttctta- gtttctgttattggttgggccaataaagccccttcat catccttcttttctgcttatcactagagacagaaactaaaaaccatggcttcaggctgctaaaagcctaa- aacaaaacagaacaacaacaacaaataaggcag gttggacaagcttgctgagtatttgggagcctttttc 1003 2444781 -- NO taatggggccaaaggggcaacacaaagcattgaaaacatcactggctcacaaaaacagtcaccttgttacctt- ctcagttgcatttgtttatttcacaaggcttc attcacacataaaaacaagatactaatccaattcaagttcataacgattataaaagtaaacatttgttgg- gacaatgtacaataaattgcactttttagacaagcat tacatttacatttatagagtgtactatacataatacatggaattacggaaacgtctaattggtcattg 1004 2537266 -- NO tgatacacacttcgaaccacagccagggtccaggcctgaacagatgtcagcatcttcagggagcttttgccag- gacgccgcccagccacatggccaccacg ttcattcaaacacggggcttcctgtcaaactacactaga 1005 3061935 -- NO aagaggtcacccttgccgtttgatggaatgcctattatttgatagctgctgataccacgataacacagagatt- ccctttcaattaaaagtgcctggacaccacag ccagacaacttctgtcccaccacatgtatactgaatttcagtcttcttacatctcatttcaaatatattt- tgaaatatatttccagtttatataaatagtataacacctaa caattcccatttatttgcaaatattattgtgaggatcgactgggacataaatg 1006 3893061 -- NO ttcctgtccagctaaagatgctgcctggccgtggcctccacgctctgtaaacatgacccacaccccccagggc- actccacggaagccttggagataaggg acacatcacttctatgctcacctgaagtgaccccattgttaaaggacacagctcaactcaatcagggcac- cagcagcgactccaagtcagggtgcaaactct ggaggctgctgtgtgaggggggcactagagatggtggtaaacagaaaggggggcttccttcaccagccag- gtgaccccaggcaagtcacaaggaacc gctctgatcca 1007 3996137 -- NO ccatggaatcctgttggagctggtctacagaa 1008 2424640 DPYD YES tgggagaattgttgctatgcagtttgttcggacagagcaagatgaaactggaaaatggaatgaagatgaagat- cagatggtccatctgaaagccgatgtggt catcagtgcctttggttcagttctgagtgatcctaaag 1009 2823618 -- NO ttcctgctactggttggttaatgaggcactgagctaggaaccctgtaagtgttcaagtgttaaaattgtgttg- ttgtacctttaaatataaggagaagaaattggg agagatcagattaaaatattaaatacttatatggtttagaaaagtgacagcataagggagatcaaccagg- tttaagggtaaatacttaggtgaccagaagatct acagtaaacttgaggacatatcccaccaagacccacaactcagctccagctgattgtttccacaatagga-

ctgaatgcctgc 1010 2491474 -- NO atctggcgtggagatcgttcaaaggtgggaaactacgggaggaaggtactcaggtgttgagtgcagccatggg- gccacttgaattagcatccaggcagcc cgcgcccctccccagagacaatcagcggtgtttca 1011 3780190 -- NO cccatgatgtctgtcgtgcagatgaatgtgtccacgcgtgctgggctagtacagaagatcg 1012 3443271 -- NO ccacagtatggtcattcagcgaaagaagtaccaagtatttctttctgttaatgagtcagaggtattaatatat- gtatgtgagtcccccatttaccctgcgcaagat aagttcttttaaatgcaattagaatatcctaagataaattacaaactcctcttatgtatccttttctctg- aggtgaaatgagacactgcacagatgagaggtactatt 1013 3249840 -- NO gcactgaacgctaatccctttttctatttccgcttctcacaggcacaggaacacaggcacaaatgcacaccac- aca 1014 3365366 HPS5 NO ggggctacttttgtcagtgtctgtacccttggcatcggcatctgtgactctttatccatgacctcagtgtttc- ttaaccaaagttgtactcagcatttcttaaccaaa gttgaattttgaaaagagtcagtccttgtttgctggaattagaatgttaatgtcctagtattattccgaa- ctacagtattaactgcttgttgctagtggattagacaga ttcttttcttactgtggcttccatgttgggagcagaagcttttcatcctggtcacatgaagacagatggt- attattgactggagagttgaattatttttatatcttgtctgg cacaatatggaaattactgaaataagacggtgtataatggaattaacacccaaaataagtagaacactga- agatttgaatttgatatttaagtaaaatgggactg ggtgcagtggctcaggcctgtaatcccaaccctttggaaggtaaagacgggaggatcacttgaggccagg- agttcaagaccagcctgggcaacatagtg agaatgcatctctacaaaaaataaaaaaaattagctaggcatagtacctgaggccaggaggtccaggccg- caatgagatgtgttt 1015 2883453 ADAM19 NO ctggctgtatggctgcatgtgacaagccacgtcccctcccacctctccccaaacccctgcatccctgtattca- cacgggtcactctgactca 1016 2924473 -- NO agcagggactcagcgtgaggcttgaagcaaacagtggaatctttagaagcctgctttgtgtgc 1017 3378661 -- NO ccctgggtgtaacgaggccattttgcaactacatccagccaggctgaaaacacttactttattccgagtccat- cagaattcttgaaaatcagaggatctctcaa gccaccccgctgaatatactctacattaaaatctgtcaccataggaaaatattagaaagataagtggtat- aattaaaaacgataaaaggaccataaaaaggat cctaagtaatacagtataaatggtgtttgttattctgtgtatatagttatgctgttagtcaataaaatat- atgcttagtaagaagcatctcttagaaaatatggagagc acattgagaagcaacgcttgaggggttttcca 1018 3754749 DDX52 YES aggctgggtgtcctgtaccagaatacataaaag 1019 3150460 -- NO gctgcccacgggactttgcaggagg 1020 2664515 -- NO ttctctttagacttaccagttaggctctaatttaggaaaaataaaacaaaaacttacatgggtttggagtaaa- attagctggagtaaaatccaaggctagatttcta ttgaa 1021 3123616 -- NO aggagggcccaatatccctgggtcg 1022 3432252 -- NO agtggtcaaacccagatgagggtcccgcttctggtttatatacaataa 1023 2593632 -- NO ggagcgggaaggagattgactgttagtttctta 1024 3054956 -- NO tgtgccagccacagtacgatgtacctcctccaatctatgtgtccaaatcagcgcatcctttaaggccctactc- agatggcacc 1025 3096135 -- NO gggacccagaagcaaccgttatgagcaacaaaaggaagacactggtttggatggacgggaagcggttgggtgg- gctggactgacggaggcccctttaga 1026 3541539 -- NO tgtgggctggccatctatatccatccatctatctattattccacccatccctccatccatccatccatttatt- taattaagttatttttaacggttggctctggagttgac attcatttattttaaaagaacagtgaatcatagctcttttcctcaagatgcttgcttttatttgcatggt- ggcatattgattaagtactcagaacactatttgacatatgg taagccctcaataaaagtttgttattattatgactgtacttctcccctctaatgtatagaggtaaacatt- ttggttcctattgtgacacgtgggttataatgagttagg gcctacttaagaagaaagtggaaagaaagcgggtaaaattgttgctcagatactagcatgtgggtgga 1027 3762591 -- YES ggggcggtggtcattaattctgctatcttagtatctctctctgttttgctgcttgtgcacttttctatttcta- ccggtgtgccagctct 1028 3305557 -- NO acctgccatcctcatagtcaccgggag 1029 2394713 TNFRSF25 NO tggcaaaagagcaatctggatccgccttagccagatacataagggtatttgccttcactttcagccagcattc- cccccagcgatcctagccagatattac 1030 2406204 -- NO ctgatatgtatctgttgggcaagtagttccatgaggagtttgtttttgttcagaatgatctttaggaaaaatg- gaaataccacggtgaagggaaagaagtcagaa tatgtacacaaagccta 1031 2722321 TBC1D19 YES tgtttttcccgggatacatctgtgttgagtcactttgcattcaacagtgcctcgccaccaaaatcatacataa 1032 3532235 -- NO atagtgttatatccgtgctgccatatcactaaaataggcttgccaaggcaggtgaggtgtatgaatgctcaag- cctcacagaactgcaatcaagtgccaactat aaataatactgaaaaaagttgaccatctgaccagtggataatactttcaaggcattcaattagcttatcc- tttgcagtattctaagctattcacattgacgatcacat acattgtagtgcttgctgcaagggaggcatataaccagttgttttggctaaaatatgacaggaaggcatt- ccttgggttctatataaaagtaacagtattcaaca gtctaatggcaatcactgataggctgcttaaa 1033 3053937 -- NO tgcacgctggaatcatggctcattgcagcctccaactcctaggctcaagggatccttccacctcagcctcccg- agtagctgggagtacaggtgttcgtcccc accatgtctggctaatttaaaaaaatgtctttgcaggatgggatcttgctatgtttcccaggctggtctc- aaactcctgggctcaagtgattttcccatcttggcct cccaaaatactgggattatacgtataagccaccacgtctggcctgagtcatctcttttgacccagaacaa- aaccagtccaggagtggctgtactccccagga gtgtacactggggaggcccacagctccggggtgcagtggggctcttgcaatttaatgactgattcatctt- caaaaaagcacaatctcagccaggcg 1034 3304915 -- NO tgggagactgacctaactgagcatcaactatgccaagcactgcgcaaggtgtcgaggctataggaacgtgcct- ttctaccctagagaagtttgcagtctgct gtgggtgatgagctatatagaagaatgtactattagatggagggaagtgagggagcaacatggttacctg- aggaagagcagtccaggccaagggcacag caagtgcaaaggccctggggtgacggtgtgtgctggctgctcatgatgcagtagggaggcctgtggctgg- gatgaagaatagtggagggtaaagtggaa agaggtgagagcagagatgtagctggcagtggggagggaatagggtgaagcagcaccatgtagggccttg- caggacattctaaggattttgactttcatc gagtgagatgaagattcactgaggggttctaagtagaggcagggacatgatctggcttcaatcatagaat- gatggggattgactaggcaggatgggttatga tgtgcaaggtcgcagggggctgctagccaggtgagataggatgtgggctctggcagcagtggagggggca- aggcactgcgggtgttggacagactctg atgattggatgtgggcctcaagggagagtttgtgtgggagctgggaaacaactgcatcaggttgcctggg- gtcccactcttaggccgacaacttg 1035 3545436 -- NO gcggtcactcagctatccaatgggatgacacacagcaaatcagctcttcactgcctcaacagacagtcactaa- aataatttctttaaaggtatataaatgttggc cagtgtaatcctctacaaaacacatttgcaaatataaaataatggaggtatgatgctgctcagagaatgg- gaatgctctggcagtccccaacatcctatcccac ttggggctttgctccgaggggaagagcaggtgcaggatatattgccctttgatgtgatgtagatgctact- agggacccactgggaagagtcccgttccttga gttatgctactgtagggatagacccttggtgtgaggaatctaacaatgagtcaaaggaaacatcacaaag- aaggtgacacctcagaggagacaaaggact ctgaaatcctggaatcacgggatatctctgattggttagggaattcctctgcactcaatctccagcaaat- gggcagattccctcacaacttagaatttttcatggg gagtgctggactgtaccccaaacatggagtaaggtggcatcatccatctctgaagggccatactcctcgc- aaagc 1036 2632506 NSUN3 YES tgaatatgatagtctgagattgaggtggctaaggcagacgttggaatctttcatcccacagcctttgataaat- gtaattaaagtgtctgaattggatggcaga 1037 3333132 -- NO cctgagttcctgggcactctttcctgagcttgcttggggctgatttgaattcag 1038 3459329 -- NO ctctggattttgccactcacacagttg 1039 3597530 APH1B YES gccagtgaaggtttgaagagtataaacccaggtgagacagcaccctctatgcgactgctggcctatg 1040 2757682 -- NO aacagtgcaagaaaggacgcatcactctcttctggtgccgatgtgctctcttgttaa 1041 2811303 -- NO tcacgtggctttgtgtaccaggcgtccagggagcaattaggagggcaatctgttaagtcttttgcctcagggc- agaaccattaggtgtgctgtgtatgtgcctc aaggggtgtaaataactaagctattcatgtactcatcagtttcctttcaaggcatctgtgaaacctttaa- tctgtggaagaatcagagaaagttgacctattgtatt attatcctccctcacctgaatattttga 1042 3611032 TTC23 NO gagtccttttgtcctgcggtccatataagagggtctggatctggagacactgtagaacaccaagcagctatca- tgaggctatggaagtgtcgctgagagcag gaaactaaggtctcccttgaatgagagaaagatgacctcattcttaggccctgctgtgatggaattagca- tgctcctgggatgtctcctagtgactgacctttgg tttggatgttctgagggatctaggcaaaagtgaacagttttagcactatttcacaaaactctctgtgact- atctgtatgcaaaaaatagatttaaaagtagtattttt aaaaataaaggcaagaaccttggtactgaccagaggatgggctccagtttctatttttaaatgtggccct- tgttatagcctggaaaagatttaaaaaaatagtttt gttttttttgtaaacacatactctacttttattaatatataggctgtctatactcttgactacacagcaa- tgtcttagttattaggaaccaaatattcagcttatggacta cccagggctggctttggcttgatttctcccttctgcttactttaagtcttgccatttgattgcttgtagt- aggctagggcaaatcaaggagaggagaaagattaaa gttgtgcccaaaatggccaaaataattttgagaaagaatgaggtggagaggtggaggaacttgctttact- gaatgccaaagacccttttatttttttaaataaagt aattaagacagcatgtttgtcacccggggtagacaaaaagaccagtggaacagggcagagagcccaagcc- ttgacagatgacagaaatggccttgcggg attggtgaggaagaggtgggctagtcaataaatgggtactgggaccgctggttttccaaatggaagaaaa- tggatcactaccccaaatcaaacacaaatatt aagctcaagaaagatttgaaggactaagtgtgaaatgcaaaacttggagcttttagatgaaaatactgga- aaatatata 1043 3977071 -- NO gtggctggaccatgcggaactggat 1044 3363301 DKK3 YES tgatggaggacacgcagcacaaattgcgcagcgcggtggaaga 1045 3644748 -- NO tgggccacgtggtgctctctgaagttagaa 1046 3799937 -- NO catgcagtccccaaggctatcggtcctcctcag 1047 3336773 FBXL11 YES gaggagcttgccaacagcgatcccaagttagccctcactggagttcctatagtacagtggccaa 1048 2822962 -- NO tgtgagaacagactcggcagtgacatccactccaaatgga 1049 3627325 -- NO ccagacctgagccacgtagctatcaaacac 1050 3780263 -- NO catctgaaattaatgggactaatgtaaggattgatattttcatatttgctcaattgcatcctgggttaagcac- attcaacag 1051 2656010 VPS8 YES atggcgctatctctgccctcagtatc 1052 3028587 -- NO tcacccaggattctcctgtacctgctcccaatctgtgttcctaaaagtgattctcactctgcttctcatctcc- tacttacatga 1053 2419066 ZZZ3 YES gttgcctttgagtgatggtccagaag 1054 3081481 -- NO atggccacctgtgttgacgtggaga 1055 3935290 -- NO atgatgaaagcgtggaggtaccagct 1056 3051677 ECOP NO ttgatgtgtgaacgctgacctgtcctgtgtgctaagagctatgcagcttagctgaggcgcctagattactaga- tgtgctgtatcacggggaatgaggtggggg tgcttattttttaatgaactaatcagagcctcttgagaaattgttactcattgaactggagcatcaagac- atctcatggaagtggatacggagtgatttggtgtcca tgcttttcactctgaggacatttaatcggagaacctcctggggaattttgtgggagacacttgggaacaa- aacagacaccctgggaatgcagttgcaagcac agatgctgccaccagtgtctctgaccaccctggtgtgactgctgactgccagcgtggtacctcccatgct- gcaggcctccatctaaatgagacaacaaagca caatgttcactgtttacaaccaagacaactgcgtgggtccaaacactcctcttcctccaggtcatttgtt- ttgcatttttaatgtactttattttttgtaatgaaaaagca cactaagctgcccctggaatcgggtgcagctgaataggcacccaaaagtccgtgactaaatttcgtttgt- ctttttgatagcaaattatgttaagagacagtgat ggctagggctcaacaattttgtattcccatgtttgtgtgagacagagtttgttttcccttgaacttggtt- agaattgtgctactgtgaacgctgatcctg 1057 2699603 -- NO aaagaaggatctgtcagccaagtcttttct 1058 2836754 -- NO agtgtggccgtttgcattactgctggaattttgaagactactacatattccgtcagtgtcaggattttgttct- tcagtgtggtacttttttttttttttttttaagatggagt ctcactctgtcgcctgggttggagtgcagtggtgtgatcttggctcactgcaacctccagctcccgggtt- caagcgattctcctgcctcagcctcctgagtagc tgggattacaggcatgcgccaccacacctggcttatttttgtatttttagtagagacggggtttcactat- gttggtcaggctgttcttgaactcctgacctcgtgat ccgcccacctcagcctcccaaagtgttgggattacaggcgtgagccaccgcacccggtagtgtggtacac- tcttaaaatcatagttcctgctgtctg

1059 3504560 -- NO gcatggccatggatcgggcaagttggttttact 1060 3924596 PCNT YES agacctgaaggcacaatcacaagaagagatcaggcgcttgtggtcccagcttgattctgccaggaccagtaga- caggaatt 1061 2408919 -- NO taggtgacggattgttaggtgcagtaaacc 1062 3219942 PTPN3 NO ggaccaggcttctaccattaattcacatgctttaaaaaaattaaaaattaaaaaaatgaaaaataaaaaaact- taaaagattttacctatattcctggaacatagtt atcttaccccagctttgtagttcctgtttaaggaaattccctctgaaggaaattttagctctcaagagtc- aaagaagatgtatagaggtggtatctgttagtttttgtt tgtttgttaaggatctaggcagagaggtcattacatttttctgaagttgaggtcacaggtggggtaccca- caagagaggtcattacatttctgaagttaggcatc ccaggcatctcttctaaagaactatcctgtattctaattgttaaataaatatcttcttcattgtgagcct- ccacaactgctgtttctgataaatttagatcattctttgca gaattttatatactggcaatctcaaaactaggctccttcaagattcctaggaagtctcccaagctcgggt- tgggttccactattctag 1063 3240958 DNM1P17 NO gtcaacaagaccttgctggacctcgtg 1064 2830809 -- NO gtgcagattgttaatccctagtgtgcagggatagggagggagaggaaatgtccacacagacgaggagaaggcc- tgtaaatgcaaatttcacactgttgatg gtttgtcctgttggttgaccagcattcccaagataaccaggtgag 1065 3020549 -- NO cctcatgcatgcttcgagatcattgtttgcttcatttccctaaaatctacagttcctttgaaagtagactctg- gcgttatcacctttccccggtctttttgcagtttcctg ttgacctctgagccattctccctcactcttgtttcactctgtttgcaacactacctcttcctgtatcctg- gcctctcatttctcacagatcatcatgctgttcttgaaac attttatttacttgattttagaaaactatactcttagtttccctaaaatctcataatctctttgcgggat- tttcctcatctttgtgacttccaaaatttgaagtgtcccctgg ccagtcctgggtggctacattcaatctc 1066 3282482 -- NO aaaagaagtcgtttattggtgcatgggacactctgggaggtagtatccatttggatgtcctgctgcggttgga- gacatggaacaaaa 1067 3192070 -- NO cctgtcggtggactgaatgggccaagtgttcagaagtccttgggaagaggatagtgtcctgaatcataatgtg- gtattttc 1068 2473609 -- NO aaagtgtcctattctcggggtggcagggaggggggcaggccacaaaggacatgagtgttaggaaaagaagaaa- gcacagggaattaaggcaggaagg gataggctaactactgttctgtgcaaatgcaattgggtttatgatcaggactgactgcccttacgtataa- agttgctaacccccaagacctgaagggaaaagtc ttttgaagctgccagttttttgatcattcaacaagaagacctgaacactgagaatcctttttctggattg- gttccatcaatactttgtccctgaaatcaggaaatacc ttgccattatgggacagccctttaaagttcttttgatgttggacagtgcccctggccacccagaacccca- tgagtttaacaccgaaaacattgaagtggtctact tgcccccgaacacagtctctaattcagcatctagatcaggggatcatgaggacctttaaggttaataaca- cacggtactctaacctcaatagaacatcatgaa aatctggaggaattacaccgctgaagatg 1069 2814779 -- NO actctgctgactgtaatggctctcacgcagttcctaatgggcactgtggaaccactcagcatagacaggcata- ggcagg 1070 3558342 -- NO gcccagtgaaggggtgacagaactagcc 1071 3611698 LRRK1 YES atctcctgccagatcacggagctcgacctttctgccaactgcctggcgaccctcccctcggttatcccctggg- gcctcatcaatctccggaagctgaacctct ccgacaaccacctgggggagctgcctggcgtgcagtcatcggacgaaatcatctgttcc 1072 3701429 -- NO tgccgcttttccctccacttgtgtaacagcatactcaggtttataccaactgggagacacgcaggcatctccc- ctcacaagcagctgtctactcaattctgtagtt atgtctgctaagtaatcagaatgcacaataggtttttagcatctgtatctcatcctcagagtagagagta- cctgttttacgagagaaaactgagaaaacggtctct cagggcctctggggcagccttcaattggacagcagtagaatttcggtccagttttcaaatcttttcttat- tgttggattgactatgccatcctgcaaaaggaaaat tactttaaattattatttcaaaaaaacaacacaacaggctggagtggaaacggaatgactgaaaacgagc- acattttgtgaaatacttttaattaagagtttttcca tctagtgtcagcagtaagagaaaaagagtatgagtagattaaacgaaatgtggtgagaatactaagcaag- actctaaaattctgcattcatttgaccattactg aattcctcttagtcaatttacattccagggagatgccccccttgtatgttcctaggctgtgaaatgctcc- a 1073 3933333 C2CD2 YES ttccgccggcggcatcaacagaaagacccaggcatgagtcagtcacacaatgaccttgtgttcctggagcagc- cagagggttcccggaggaaaggcatca 1074 3799749 -- NO ttggattccactaatcacccgatcacccc 1075 2487131 ANTXR1 YES gaaagctgcactccaggtcagcatgaacgatggcctctcttttatctccagttctgtcatcatcacca 1076 3187719 -- NO gggcaaacttcagcctcattagatagaggctggacttccggaagagctgggaagggggaccatagtttctggg- gaggggtggagaactcacatttaccta gctgctggccaggctattttcatacccacagaccgatttaattctcaactactgtactcatttagtagat- gagaagaatgagacattgaaaacatgcacagtgga ggtgggaatgaaagccagctctccaactctccagtcctctttcctgtcactgcatcaggctgcagggtga- aggggaggtctgggatacaaagagaacttag aggtggagcagttggattctgtgcagtgctaggagggaggagaggggttggagtaggtgggaagtaggcc- tccttcagtttggatagcacttcccttaacc caatgactctagtgggagggtggagggatggggatgggaagggagcctgggagtgaggaggaaaggcaaa- ctctgtcttcccccaggggagtcaatg aatagtacc 1077 3474744 -- NO ttagtgtacccttcggtgacaggtaagggctttctgaaacgcattgtctttttattatagccattctagtagt- aaggtgtgaagtggtatctcatagtggtttgggtt gtatttccctgatattgggatgttg 1078 2489696 -- NO atgcagttacaaaatcggattcagcatcagaacag 1079 3195395 ARRDC1 NO gtgagtcgacagccagggcttggca 1080 3497381 -- NO ggtggacagtgatggtttcaaaggggaaa 1081 3130174 GSR YES tcattgttggtgcaggttacattgctgtggagatggcagggatcctgtcagccctgggttctaagacatcact- gatgatacggcatgataa 1082 3180421 -- NO gagaggtggatctgtctggacttcaggctgtgagaacctcacagcacagataggatgtgagctttaccccttg- tgttcaggccgctcgcacggagtcagctt gcggaagcacgttcccaggcctgctctgcgtgtaatggtggaatt 1083 2384882 GALNT2 YES gaagtcggtgaagcacatggatttgtgccttactgtggtggaccgggcaccgggctctcttataaagctgcag- ggctgccgagaaaatg 1084 2601621 -- NO tctcctgcttcctagacgaaatctaagcaatattttatccacttctttttagtaaaagaaatacatattgcct- gttggggtcatgagctatgtagggaatgaaaaaat tttttaaaggagaattataaagagaaggaggatacaagagaaaggaaaacgaaagctggtgggaagttga- gccatgtttatctctagtggaatccttaccttg tgttt 1085 2624206 ITIH3 NO tggatggcccggattttatggcatctggaac 1086 2626149 RPP14 YES tcaagattgtggagttggactgaatgctgcacagttcaaacagctgcttatttcggctgtgaaggacct 1087 3466862 -- NO tgtcacttagtctactgccagtctactgtctgtgccaccatgggaaattgcatgagttcagacctgtgaaaaa- tcagaataaagataaaaacacattttttgaag gttacggaaattcttaagatcttggttttcttgaacttactactagtactactgatttagaaatggccta- cctcctatagtaggaaagggcaaagaaaacaatagtt aatagggaaggcttaaaggagcttgagggctgtcctggcaataatagaagagatccttgttttttaaagg- agagttaatgtacaaagattctgaaaagtctaga aacatgggtaaaatttttatgattgccgggcgcgg 1088 3400762 -- NO tcaatgaccagcgtagacagagctagtagcagcaatgagatgagtgactagagaggtagagagaaaaccagga- aagtgtggagtcatggaagctaagg aagatggtgttgggaatagaggtggtgaacagagtcccctgttcttgctgataggagaggtcaaatgaga- taaggacagaggcgtggcctttggattccga gatgtgttgatcaccggtgcacttggcaagcatgcca 1089 3511392 KIAA0564 YES aatcccgcttccctgtactttatgaatatgactgggaaaagtggcttctttgtggacttttttgatatcttcc- caagaacagccaatggcgtttggcacccttttgtg acagtggcaccgctgggaagtcctctcaaaggtcaagtggttctccatgagcagca 1090 3762555 -- NO tgcacatgtggtaagagcatccagcaggaaagaagagggcaagttgagtgtgcgtgggcatgaaggattcact- gtacgcatcccagccctgctcatctca gccgcatggactgggcacacatttaagcatggagggtggtggttttcaggctgttttctagagctgtaga- actcaaatgaaatgctctgagtctgtgaggggg ggaggagtcaataaagggtggctaagtgcatggagtttgaggtacccgctctgctgtaacc 1091 3853067 ILVBL YES gcttgctgctctcacgggagaacgaggatcaggtggtcaaggt 1092 4015570 -- NO ttcatggttgcctagtgctgcgaggagtggggaatggggaatgagtgcttaatgggtatgggtttcttggggt- gatgaaatgttccggcactaagttgtggtaa tgactgcatgactttgtactaaaactactaaattgtacactttaaatgggtgaattgtatggcatatgag- ttatt 1093 2458440 -- NO tgcacttttgcctccgaactctcgtgtttaatta 1094 3333734 SLC3A2 YES atgggttccaggttcgggacatagagaatctgaag 1095 3379257 -- NO ggccgtgcagcttcttgacaaattgcaaaggtgcccacgagtttccaagt 1096 3662461 NLRC5 YES ctcaacttgatcacgaggttcctgacaccgtccgagctcctttttgatct 1097 3670791 -- NO gtgcaggtctaatgggctccttccttc 1098 2689662 -- NO ctcatggcaacttcttccgcttcctagtttca 1099 2698749 XRN1 YES gctgggatcactatggaagcaactatgcattgggggca 1100 3940626 -- NO tgcaggctttacctatgaccgaacatgcatggaaatgccctctgatggactcaggcatgatacatacatcaaa- cagccttgcacggtggta 1101 2577438 -- NO gagagcatggctacaacagcaatatttctggaaaccagttatcgggggaattcacagg 1102 2885881 -- NO atggactcatcccagaacaatcctcaggcactccgaaatgcagatgccc 1103 3473848 TAOK3 YES atggctccagaggtgatcttagctatggatgaaggacagtatgatgggaaagttgatatttggtcacttggca- tcac 1104 3721713 -- NO agaacctggtcgtgtcttgagaacccagtccaaacagaatcaggcctctggactgggagcaacactcccttca- cccgcaaagattcaggaaaagcacccc aaggacaaggaaaccaatgaggtctgggctagctctgcagctttaggatactagctctagggaaggattt- tttcctttttaaacagcgtatcactctgttgccta ggatggagcacagaggcaccctcatagctcactgcagcctcaaactcctgggctctggcgatcctcccgc- ctcagcctcccaagtagctgagaccacagg cacgtgccaccatgctcctagggaaggagcttgagaagaaactgccaggagtgaaccagggctggctgct- ctgtgatgttctctccccacctcccctccag ctctcaacttggtggcagggccggcaccctgctctccctcctaactcccagcctgctgctgcccccttct- gggaccctaattttctggactttgagaaatgggc tgcccctgggggtgcctccaagagcccatttgagggatcgggtggggctgacctctctgtcttctttgga- tcatcgccttctcacactgtcctccctcttgattct gaaaaatggtcctgctgcccatggagaaccacagtaagatagatttctcatgcagctagtgaggggactt- c 1105 2924660 -- NO accatgtttttgcctccagtctgtc 1106 3242466 -- NO atggctatgggaatatcgggagttgaggaagaaaaaggctccagtggcactgaag 1107 3268238 BTBD16 YES agcagctcaccaccggctgcgagaagtggctggaaatgaacttggttcctctaggggggacgcagatccacct- ccacaaaatcccacaggacctgctcc acaaagtgctg 1108 3293847 SPOCK2 NO tgtggcatgcgctgacaaatgtgtccttgatccacactgctcctggcagagtgagtcacccaaaggccccttc- ggcctccttgtagctgttttctttccttttgttg ttggttttaaaatacattcacacacaaatacaaattgacaggtcaaaatcca 1109 2416565 JAK1 NO aatcttgctttttgtggcctggggattggctgtgtgatcagcattgaaatgggttgttgcagtttgaagtctg- gaaggggtatgtccctgggttctaattctttccct ctaggtttctgtactcagctcagagtctagaatggtagcttttaggattggaaaagaccaaagttaccta- attcaactctttcatttttttttcagtggaaaaactaat acccagaaaagggaagagagttaacccaaaaattacatctagtgaattgtctgattagctttacaattga- ggcattgtagagctctttgaggcattagtcttggtt gtctgagtgcctggctattaaaggctgtctttgcctgttccctctttctgttagctgcctggaagtgcag- ggttgcttcacttttagcaccttgactctgtacctgac atggtgcttcaacaggatattgc 1110 3198506 -- NO gtctacgcagctgccatagaggagggggattgtttgggagaccttcccgtggcagaatcaaagctcgtagttc- agctgcgggaatctggtgtacttaa 1111 3384336 RAB30 YES gggaagacgtgcctcgtccgaagattcactcag

1112 3649726 -- NO ttgtgcaacagaaaactcaacccaa 1113 2732288 -- NO aggtttagttgtgtggccgtaatcacatccaacaccaagtcggccaaccatatgtgagcttaatcccacagaa- ttcttatgttagacctccctcttcagataatag aggagattttttttaagtatacgtgcacagaggaagtgacttctttctgcgcactctgttgtcactggaa 1114 3291868 -- NO tacgaggaagtgaccagtgttcatctgaaacggatgccttgtttctcagaaatgtcattctctttatttcatc- ttcgtagttctgtgccttctctcagcaatttctgattt ctttatttactgccacacagatgacaaatgacatgcatgtccatgataccctttactcaattcacatgcg- atttccaaggctggctataattcccaaa 1115 3572359 -- NO gtggggggctgtaatctacaaaagccatcttcagtaccaggtttaattccatcattgtttttcgggttttagg- tctctggactattgtcctttaacaacaaca 1116 3613987 -- NO gcctgcctgttcatgccaaatatacatcctcacaatgcacagtacacaacatgggcacataggcacagaggct- atgccgg 1117 3768275 -- NO ggctttgaagggcaactgaccaacttttttatacataaaggatataaactacaactattttcccactctgtgt- agaatgtggaacggaaacagtgtgtggcacac tttaaatgatgctaaacttctacagtgtgtaaactggcttgttcaagaggccaaagtgcttctgttgaga- aacactgatgaccaatctcctctttgtggtcctgtga tactgtgaaatatatatttgatcttcctccctgtttcccagcatacaattcctaaaaccctcagaatctg- caaaataagatttttttttaatgctaatgattgactgatg gctggaggctcctagagagcctcaggattggggctgattctcagggctttc 1118 2367980 RABGAP1L YES gaccatcttctccaggtggactacctgaagaagatagtgttttatttaataaactgacctacttaggatgtat- gaaggtttcttccccacgtaatgaagtagaggc tttacgggcaatggcaaccatg 1119 3063344 ZNF394 YES gtgtgaagaatgcgagaagagcttc 1120 3147137 -- NO tttaggaaaaggctgctatactgtggacgaagtctcagatcagaa 1121 3737089 CCDC40 NO acgggacgctttctctgggatgcattgagtcagggaatagaagatggggtgaatgatgtttctgacccacaga- ccgttgggatgcttttgctgtcactttccca tcatgctgcatgaggcatgacagcagctgt 1122 2686311 FILIP1L YES tgccaagcatgcgatattcagagtctccccagaccggcagtcatcatggcagtttcagcgttcaaacagcaat- agctcaagtgtgataactactgaggataat aaaatccacattcacttaggaagtccttacatgcaagctgtagccagccctgtgagacctgccagccctt- cagcaccactgcaggataaccgaactcaagg cttaattaacggggcact 1123 3307401 -- NO gccactctgctcaaagttggcacgagttggaatgtaatcaccatctctgcactcaaggcatgcagaaatgaag- tctacctcagccctcaaagacctcacctg agaaaaagacaaggctccaaacagaaggcaaaacagaatgagcatagaaagagaccactttttcacatac- ctttacaaagcactgctcacccctccttaac ctcgcacagacagagcatggggcctcagtgtcactgccactgccaccctcccactgactagctgtactct- ctga 1124 3648042 CIITA NO ctctgaggacactaaccacgctggaccttgaactgggtacttgtggacacagctcttctccaggctgtatccc- atgagcctcagcatcctggcacccggccc ctgctggttcagggttggcccctgcccggctgcggaatgaaccacatcttgctctgctgacagacacagg- cccggctccaggctcctttagcgcccagttg ggtggatgcctggtggcagctgcggtccacccaggagccccgaggccttctctgaaggacattgcggaca- gccacggccaggccagagggagtgaca gaggcagccccattctgcctgcccaggcccctgccaccctggggagaaagtacttctttttttttatttt- tagacagagtctcactgttgcccaggctggcgtgc agtggtgcgatctgggttcactgcaacctccgcctcttgggttcaagcgattcttctgcttcagcctccc- gagtagctgggactacaggcacccaccatcatgt ctggctaatttttcatttttagtagagacagggttttgccatgttggccaggctggtctcaaactcttga- cctcaggtgatccacccacctcagcctcccaaagtg ctgggattacaagcgtgagccactgcaccgggccacagagaaagtacttctccaccctgctctccgacca- gacaccttgacagggcacaccgggcactc agaagacactgatgggcaacccccagcctgctaattccccagattgcaacaggctgggcttcagtggcag- ctgcttttgtctatgggactcaatgcactgac attgttggccaaagccaaagctaggcctggccagatgcaccagcccttagcagggaaacagctaatggga- cactaatggggcggtgagaggggaacag actggaagcacagcttcatttcctgtgtcttttttcactacattataaatgtctctttaatgtcacaggc- aggtccagggtttgagttcataccctgttaccattttggg 1125 2568862 -- NO tcttcttctagcagtgctcagtgggt 1126 3405549 DDX47 NO tggcgtgagcgagataaacctcctaacagtaggtttgtacaataaggccatagggcaccgatgcctgtttcca- taattgttgtaattttatgggctttgaagtgtt gctctagatacttactttctcctttcagggtagcgagaggctcccattagaatatttcatatgtacctgt- ctggtttgcaagctgttgagttgatttattcagccctag tggtaataatgactc 1127 3479324 ANKLE2 YES aactgaaggagcggatcagagagtattta 1128 3736140 -- NO tggatgtctactttgcacgctgcgattgggagagctgtcccgctgcatgcgttccctctgtaatttcctcaga- gctcacatacgtacctctctcacgagtgaact cagattttccattgttttgctttattctatcatttgctttgtggttttgctgtaaatattgaaatcttaa- tcatcatcgagaggcacagccaagctttccagctctccacc cccgtggcccatccaagtctgttcatctggtaacttctgttgtctgggacggcagcaagaagatgccggg- gcttgcctggagtcctggcagaggagtgcca ctcacttttgcctagggtccagttggggcttaaaaaatatttggagagaagagtaatgaggattttttgt- gtttcctagacattttatgcatctatttttgtaaaatcac cttcgctaactttcaccaagcactttgagcacagtggaacttcagaagcacaaccagcctaaccccagaa- tctcaggtggcacagctagaaattgagtccctt cctaggacactggccgtggccttcagggtgaccagtcagtgccaccgggttggcattggtgttacagaca- ggcctctgaagacaaaccgagcaccccag cggcccctcaaactaagcaaggatcttttttctgtctgcgctccctggggcaaggtcaaaggtggacccg- cccactgtgggtcaattcatcgaaaagatgg gacccgcacccccgccacaggctggcccccccccacccatggggaaggtggtgtgctgctggctctgacc- atactcttttggaaattgagaaggaaagca ttgagtgggacctaatccggagaagaaattaaagaccagaaaaagaaggaagctgggaatgaaactcaaa- atgcacttgaacctggaagcggcaaccct cagctctgcgcggccgagcctcagcaagagttcgttt 1129 3954953 -- NO catggtctaaccacagaggggaatactactcagcaatacaaaggagtctctcctaatacgtgcaacaacattc- atgaatcccaaaaactttatctggagccaa gccagacacaaatgtgtacatacagtacggaatgacttcagattctgaaaaaaggcaaatctgaccaatt- gaggcagaaagcaggtcagtggttccccagg tctgggactggggtgggttactgatagcaaatgggcatgtgggtgccttggggtagggtaaaggttccat- cttgatcacggtggtgtttcccaagtgtata 1130 2396759 FBXO2 NO tcgagggtagataggccttaacttagtccatagcgtcctcaccttccccaagccacacatcctcctcccatcc- cttgctccgatcccagcccctgagcaggga gagagaagttttgttggcataggtttgcttaggtagccggcttctagaatgtagatccgtgagggcgtga- gcttggactggacccactgctgattccctgcac ctagcacagtgcttgccacaaagtgggctctca 1131 2519281 ITGAV YES ggtgagcgggaccatctcatcactaagcgggatcttgccctcagtgaaggagatattcacacttt 1132 3640619 -- NO tctgttgtctcgcccttgctctgctcctacttcacccatcttctgagatccaagtcaaaatcatctgcacg 1133 3976861 HDAC6 YES acctaatcgtgggactgcaagggatg 1134 4048293 -- NO ggggtagaacaatcaagcttattcctaaggattttcttttgacaaataaatgggtggtagtgttgtttattga- gataggaaaaactatgggaggaaatgatttgaa gtgggtggtttgaaataaaagttttgtttaaatatgagatgattgattgacatttatgtggagaaatccg- aaggtcaatggcatttaagagactcatggtgaggcc agggcttcaggtatttatgttggcagcagcaatacgtgtagtgtgttaaattccagggcgtg 1135 2393657 KIAA0495 NO ccctgtttgtctgagccctttggagatttaggttgagtcatgagaaccggtcattggaacatacactttatta- tgttacaaaaacaaaaatccccactgaaacaca gctaaaaaaataacacattttcccaagattacattaccaaaaacagttgttatgtcattggagggcgtcc- attaatactgctcggagaagcacgatcttaca 1136 3389355 CASP1 NO aggtttttggaattatgtctgctga 1137 3584178 -- NO attgtagtttgaagagctgcccttgggaactcatgggacaggcatcaggcctggaatgggatggacaagtggg- gcctccaggagaaggagcattgcagg agatgctggagagtggggagcagtacgtgcagcagatagggga 1138 2365984 MPZL1 YES tcaccagttaagcaggctcctcggaagtccccctccgacactgagggtcttgtaaagagt 1139 2468456 -- NO aaagcaatcttaacagtgagggctatgaaaccgttgaaaattctcccaagggaagtgatggaaacctccttgc- ttgagtcatttcaaagtcgacaaaacaacg aaaaatacatggagggagggatcctgtagtgttggggagcagactcgatgatttcatagttcttttctgt- ctctgatttccatgttctgtgaaatagtattgcagct aagaaacatgaaatccttcactccgacagtatg 1140 2954656 YIPF3 YES acctgcttcggctactggctgggagtctcatccttcatttacttccttgcctacctgtgcaacgcccagatca- ccatgctg 1141 3499189 ITGBL1 YES agatggcatattgtgctcggggaagg 1142 3102170 PREX2 YES gaaggatattattacagagacaatgtttctgtggaagaatttcaagctcagataaatgcagcctcactggaaa- aggtcaaacagtacaaccagaagctc 1143 3151372 -- NO caggcactgtatcaggtgctgcgtacttctgctagctcatctcacctggtcatgccgctctga 1144 3153640 -- NO ttcttccttgatgcaggatctgaggttgaag 1145 3708351 -- NO tcacattctggggttagaaggggcccaatggatgggaattcttcatataaaagaggaaatgcc 1146 3793991 -- NO tgcaacaatgggagctttttaactagtctctgtaaggcgttgtcatcacatctg 1147 2840186 DOCK2 YES catgagttcatgagtgacaccaacctctcggagcatgcggccatccccctcaaggcgtctgtcctctctcaaa- tga 1148 2945913 CMAH NO ttgcctcccggagtgtgtaaccacatgagaaatagagggaaggttctgtccttaagaagttaaaagtgtgact- gggaaggtaaaacatacttattaagggtta actagcatcatgccattctgtgtgatggtgagtttgtgtgtgtgtgcacatgtgcgtgagtacacacata- tacatttaaaaaggtcttgaatataccaaaatattat gtctaggtgatgggtagcttgtatattttttctgtatccttgtctgtgtttgtcaaattttatagaaaca- ataacagtaacagctctctgaccttctaccctgtatgttct gcgtcctgtctaattcctcaagttccttcactgcctgtcactctgatgcttgctatatatcagcccatcc- tgctttttgtttcttagacccaaagtgtcaagtgcacac ctgccctgggtctttgtgtttgctgtttccatttcctggagtgcagctggccctgatttgcatgtgacca- gca 1149 3706405 PAFAH1B1 YES tcgtcactggcagcgtagatcaaaca 1150 3898481 -- NO atggcggcagagtatctggttctctt 1151 3962245 NAGA YES tgctcttgctgggacatgtggcccaggtgctgatgctggacaatgggctcctgcagacaccacccatgggctg- gctggcctgggaacgcttccgctgcaa cattaactgtgat 1152 2877309 BRD8 YES cacagagccatggtccatccgagagaagctatgttt 1153 2973720 -- NO gtttggtgtctggtacttagagctccctgaaactgtggtgttt 1154 3091762 FZD3 YES aatcatttgcctctcggccacattgtttacttttttaacttttttgattgatgtcacaagattccgttatcct- gaaaggcctatta 1155 3418179 -- NO ctgagctcatccagtaaaactctcaaaagatgaatagatgcccttttccttgaggagccttctgcctgatttc- tttgtcactgagtttgggtccctggttggagtgg caggaggaaggggtccaccacgtcttctgac 1156 2685385 -- NO tttggtgtctttctgaagggattcggcccggag 1157 2912792 -- NO ggatgaaatcgtgcacgtccctcttcgtccctctcaggacagaaattcttttgtccagcatatatctatgttg- catataccaccagccaattagtcacttagtagct ggtgttggttatgagatcaactgtcatagtatcacagtgcttgtttcaggtaacccttatgttatttaat- agtggcccaagagtgcaagagtactgttgctgacaat ttggattcacgagaagc 1158 3590727 JMJD7 YES tctggtatgacatggaatacgacctcaa /// JMJD7- PLA2G4B 1159 2363028 -- NO gaaacgccgtcctgcggaaacatccaccatccggacc 1160 2374733 -- NO tagagactggatcatagaaggagttgtttgccatgcttacccttaaaggctttctgagcagtcatcctgggat- ggacagggcagggagtggagagaccagc gagcaggtttttgttacggttcgagtgagggttgaacacaggcagtggtggtggagatgggttgcaggga- taatcttgagagagatttaggagacaagattc acaggttg 1161 2448301 TPR YES gagattcagcgattgcaggaggacact

1162 2596900 -- NO gaatggtgggaaatgtatgcttgactcaaaacagccag 1163 2713805 ZNF595 YES ctatatgttctcctttcagccaagacct 1164 3878694 -- NO ggggtgtctgcgtggggagaaatcagttgtcggcattttaaatctctggataatgag 1165 2434634 ARNT NO cggctgttgatacgattgtctgttatcgaacacattcagtgataaagctgggttactgctgcttttggtgctc- tcaccttatctggaagatctgcaaacattaccta aataggctggcaagataaacactttctggaacccgagacttggccataaagataatgctgcatttttctg- tcagaatcacatatgatgtgtgttctgtagaggtta tttctgcatggaaactcaacttcttggattagccgtcccagtgaaaatcctcattgttggagtgtaaacc- aaatacgaagccctcttgcaaagtagcctctttcat cccatactcaaaatacccagtttagcaagcaactgagatttaagtctctctggccctaagaggtttttcc- tctttgctccctccaatcttgagattgggttttgcttta gagtgcaagtatcataattccgtatgatagatggggcctggacacccatctcaacagggtcacttggtaa- ttaacaatagccatataaatgcggatacaggtt actaccctcaccctttaccttcctcaggtaacagtcgtagataccagcttttttttttttttttttaaat- tggctttggccagtagctaaagtgcaagactgaattaatg agaagatatattaaatgtagtcataggggactgaggagcaagggtggccttgaagaggccaaaggaatgt- ccatttgctgagtttcccttccttatgtctccag tctggtgccaggtagtggagtaaaaaaggagacagtttatttttttattctatgtgcacacttacagtat- acatatatatttatatcacaatttacgaaaccaaaaag ttgagtttccaatggaacccttgttttttaataatcgactttttaaatgtgatcaggactataatattgt- acagttattatagggcttttggggaaggggaggatagc gagaagatgctctgggggttttgtttttgcttttccttcagggttttatttttgactgttttg 1166 2502158 -- NO tgcactttcccagcgtttctgtctgc 1167 2511348 -- NO agacaacagtaaagaaataccagcaatttgaagccctgtccctgaatcctactcctgttgccttcatatcgag- agttccaagtgttggcctgcagttaagttctga 1168 2697262 DZIP1L YES ggaactgcatgaagagcacatggctga 1169 3829727 GPI NO gttctctgccaagtgctggccagaggcgcgtgtgttggtcctggtcccccgctttctcccccactgtcctgtc- cctcccctccccgtgcagctgctcag 1170 2566885 -- NO cctacgaggtccatggcagcgggtacttgaaggattta 1171 2644609 -- NO ggctttgaggatctctgtgccactttg 1172 2681773 FOXP1 NO tccttacgaggctagagattttctgacaacagtatgttagtttcatttggtccgtgaatggagatggcagcaa- atattctcagaccctcccagatctggctaaga catccccttatttaggaacgaccctcccctggcataccctactctccatcgcctgttggcaataaacgtg- ccttgtggatattccttaaaagccttcctgccatcc ctctagcagtcactgtaaagttcaaatctcaaagatgcttaggagccaagattctctctgctcgtgccca- gcagcccctgctgtgagctcactgccttccccag cacgacctcctaggctgctgccttcctttctgttggagtctggagtcaggctaactcctaaaaatctgca- gagaggtctctggagggaggacccaagcctgtt actacctaagccagaattttacacctagtttccttgaatagagaagtccaaccccagaggtgtgcacaca- cacccgccctgcaaatcagtgacggggagaa agcctgacttttcttgggttttgctagtgggggaaattgctcatttggaagggcaccagcaagctta 1173 2941811 -- NO gtgtcgcttttattctaactgctggaactatttgttgtacctctttctgaagatcagtttggggctaaattac- aagctccatcagcacaggggccatggctgcctcc tgactgctgtaggctgagcacttggtagagcatcagccc 1174 3037970 -- NO tcacctaaaaggacgaatccatctgcttctgtctctggtactgagggctttttagattccggaggctttctga- aga 1175 3235439 SEC61A2 NO acactttgacggatcgtttttgtcagatga 1176 3670576 -- NO ccaaggtcacacaatacgaggtggggtcagaatgcaaacccaggcagtgtgcctacctagcccagactcttaa- ccactaagatgtcactaaagaagca 1177 2682104 -- NO ggagatttggagtacttggagcatggag 1178 3809910 -- NO gggaccttgtccctctttgcatggagggatggtttctttaggtcctgggggatagcccaggccacttccactc- tgaagatctgtgttctttatcagtctttcaatct agtatatttgcatttaataggtgacaaatgggcctggaagctgtggtgggg atggagtgggaaaccagctctcagtctgacattgactcctggaggggagg gtcacctctgttcctgggcagcctttcagtggcgaaggccaccatcccccacagcgtgattgagaagcct- ggcacttctgcaatgagtactgtggagcctga cctttggctagtagcttggtctttattgacagggctgtc 1179 2428310 -- NO cccgggtctgtcataaccgcaaatttctataccactctgctgctttaagatatcaacaggcaaaagataacca- ctgtccaactcacataaaaataggacatcaa gttttgggggacttcatgtcctacctccagcttactaagcctgctatctctggagattccactactgcaa- acctagttaggcaatgggtaatagcattacccatta agccaaatgtggagtgaacaataataataatcactaggacttggagagtcactaaataaagatttgttga- gtaagtggaggaaggctgccttctaagctgtgt atcactttggccccaacctgcagtactccttcccactgtagccactgactcctgctcccagcttcaaagg- ctaggatcctctcataaagaattaccaaagccag agatccctacctgcctaatatatactgatgcctcatgtgggcccttga 1180 2429289 -- NO tgtggtttgattagtaactaccctggagtgtctcaacttt 1181 3246430 -- NO acccgatgttgacagtttctccctccctctctctctctgctgtttcctctatagagctaagtctggtttgcat- tgaaataagcatgcagtaatatgccttttgccttac caacttgtatttgcacacaggcagca 1182 3314235 -- NO gtgtcctaagcgggtgcatgtccag 1183 2332841 ERMAP YES tggagaagagcccggttgcattttg 1184 2452077 PIK3C2B YES catggtgatgcatattcggggcttg 1185 2592323 -- NO atagagggttcttgcagctgtccaaggtagaggcagtggaagcttgcgctcagtagaatcagtggaggtagga- agaggtggacagattcaggttatgcttt ggatgtgataccaatatagaaggatccttatgttgaaggattagatgcaggagtgagagcagaaagtcaa- ggatggctctacagcagctactagaacccctt gaaaaatggtaatgctgtacacggagctgggaaggcaaggagggggcaggggcaggagttttgtaggact- caataggtttgtggagagaaaaggaggc tgatgggaaaatcaagggctttgttttgagcaacatcaagatacctattaaatattcaaggcatcaaaca- gtaaatgagtcagagttgtactagtatcaagatttt tgatcattgttttattaatcctaatacaaaccttcctagttgtcagggttcagc 1186 2895598 -- NO atgttctcggaacaaggaaccagtaaagtacagacatctggccccaggattttgctggctccagggacgtcac- tataaacccactaacactaattgctttcac gtctgctcccatttcta 1187 3578431 -- NO catgcgaaagcaacagtctgatctccaggttatgaaaactataattaaaaagtcactacacagaaaaggtcca- agtttccagcttggcaaaacttgggtgcag ttacatgaaacgtttaataaactgaattgttttccccaatgtgtaaacaaaatgacaagactaaatctgt- gcctggtaatttcaatctaactctgaagctacacaaa acacacagacaccttgtacatttcacctgttagtatgaccatcttttttcttcggtggtggaaggaaggg- caaggtgactgtgtaaagcaaagatgtgggaagt agaaatattgtttactagacattataaagtcatggtgaaaagaaagcttcgattaatgcatagcctaagg- g 1188 3590373 -- NO tcttgtggttccttaacttgtggcagcataactccagtcttcacatgaagttcttcctgtgtgtgtatctgag- tcctaatataaggagactagtcatattggattggg gtccatcctgctctgttaatgacctcatcttagctgctgacatctgtaatgactctattaccaaataagg- tcacagtatgaggtagtaggggctaggacttttaac atacgaatattgggaggacacagttc 1189 3277334 -- NO tgcctgcttcacacaagtcgaactgcaactgggatcttggcttcttgtcaagtcagtagcatgcaagccagtt- taagtcaaaagaggacacactcctcttactt gattccccttgccatctattttctccctcaatcttagccacttggagaagaatttaataccttttttttt- tccagagtccaaaggctgtggatctaagtggggcattttg tgctcaagcgaatctgccatgcactacggtttcaactc 1190 2323027 -- NO gagcggtatcttgaaggtggctttaagtttgggaagttcgggaagagcagtaaaggcacgatactgggactga- gcccagtaggagt 1191 2360843 HCN3 NO tgtcagcagatgtcttgggtcctgagt 1192 2834307 STK32A YES gaataaacaaaagtgcgtggagcgcaatgaag 1193 2890310 C5orf45 YES aagaagaaaacgtgggacaccagcaggc 1194 2510000 -- NO gataatgaagccaacgcaaaaatccacgtctccaggctaa 1195 2575065 -- NO tctttccagctcatgtctcccggggggctgggctgtctcctgtcctgcagccgcagcacttgatctcagcagg- tggaatgcagagcagaggaatccgccag acattacagggatctatctgagtataaaacgggactgctctttccactaaattgcttttggagaataaag- ttaagtgaattaaaatttccccagtctcaattgctaat atggtaaatattcgcagttacaactctcattaacaaaatctcttaggagtcctcagtaatttgagactgt- aaagacgtcttgatactacaatgcctgagaacgagt tctctggatcttacctgcccctcttacatgaggaggcaccctgatgtctgggtggcttaccctttggcct- ctggcgggcattcagcatgagtgaa 1196 3336723 FBXL11 YES tttaatgtagagtatattcagcggggtggcttgagagatcctctgattttcaagaattctgatggactcggaa- taaa 1197 3660063 -- NO catgctctgacgctctatgccactgctgcacct 1198 4029263 -- NO taaaagactgaacaagaagggcacagtgttcacggagattgaagtgaacaagaaa 1199 2663789 CHCHD4 NO gatgaagatttggacccttccattcataatccctttctaagtgaagggagaggctggcttggctgttccttgt- tattccgaaagccctggtttggggcccatgttc acactggctctcagtctagtcaggtgca 1200 3743045 -- NO gccactctcgtgctgcttgagctgc 1201 2826559 -- NO agcaaagactctcgggaacaccctattacaggaaaatctctcatacctgacctctgcttaacccactcgtgag- attaaatgatagtcttcattctctctgtagaat ttgctgactgatgctcatgctacattgaatgacagtagactattctttagttttatcttgaacttttatt- ccccccagttactgtagacttaccaagaaacatttgtgttt gtacccaacacactgttatggcacttgatgttgtaatcacatagtttaatgaattattattcagtgaact- ctgaagataaaaaggcgtttgtatgagaaccaattgg ctactttgaaatcaagtgagtagccaaaatcaattatggttgaaatagatgagggttaaataattttaaa- tgattagggaaaaaaaaacaaaaaacacctaacg atctaaaaaaatctgcaataatattatttttcacgtttgtaaaatgtctttctgtgtttaagaaacagaa- actggaaatcacaggtgttgttttatgggggtagtttttg caagaaaaaggaaatagaactttcttcgatagacccacactgga 1202 2882611 FAM114A2 YES gtgagccagccaagaattctgagtctgttgaccaaggtgccaaaccagagagtaaatcagaacctgtagtttc- cactcggaa 1203 3044784 -- NO gacccacggcaattttgaatacttggaagagcagtctaagtaccctcacacaa 1204 4016017 ZMAT1 NO tgtaggtattcccatggtttcatccttgaccttactctacaaacacgatttctatttccctgatttcatttct- catctgtatgcttatgacctttctgtcaagtattagattc acatatccaaatggcagctactgcttcacctggatgcctcatagcca 1205 2872559 -- NO ttggtgatgctttatcgacctctgagaatccctttgtgatctgcagtgctactgtggttcacaaaatctgtgt- tcttgctctccctgatagcatctgacatttgtcatc aggggttggcaatc 1206 2810393 MAP3K1 YES tgctagtgcaactactgctccatcgatcccttcacatttgtctcctggtttacgagatgtggcttcgttgttt- agaacttc 1207 3309863 -- NO aagtgtagcggcaggcatcctggga 1208 3349873 NNMT NO gaatgctgttagcctgagactcaggaagacaacttctgcagggtcactccctggcttctggaggaaagagaag- gagggcagtgctccagtggtacagaag tg 1209 3849058 -- NO gtacatcattacccggcacagacaca 1210 2609601 -- NO cccctcaaatcttacagctgctcactc 1211 3489275 -- NO tctcttgattagtctaggtggtggtttagttctgttctgattttttatttgttttagagatggcatcttgcga- tgttgcctaagctggactcaaactcctgggctcaagt gatcctcccacgtcagcctcccaagtacctgggactgtaggtgtgcaccactgcacctggctgtctgctc- tgatctgcaccactgcacctggctgtctgctct gatctttattatttcttccactaattttggatttggtttgttcttgcttttgtagttcttgagatgtgca- ttgctagattgtttatt 1212 3490771 -- NO tctccgtattgcttagggtggtctcgaacttctgacctcaagcagtccttcggccttggcttcctgaagtgct- agagttacaggcgtgagccacagcacctggc ctacatattacatttaagtctgtgatgcttttagaatttttatgtcaagtgtgagatttaacttgaggtt- cctttttgtggggtggatagtatgttcgggtgttctggcac ctatcttttctcattgaattgatttgcacctttcttaaaaatcagttgagcgtatttgtgtgagtctatt- tctaagttccccactgtgttagattgagctgtatgtgatcta tatgtatgttcctctgtcagtcccactgtcttaagctgtagctgtttaagtctgaaattgggcagactca- ttcctcctacttta 1213 2353513 -- NO taatgtcatcatcagtgggcaagtctagaaccctaatatcctggtgctcaaaattagtgttatcaattcagtc- ttctccacattaaacaatttccaattcctttgagg cctggtgtgatggattctgtctttcaaatgctttttttctttcagtgactctatcgttcataaatgttaa- ataaaaccctcactctgttataaaaatatagactttaaaaat tttccaaagtaaacactccagagaaaggtaggcgggctgaataggctgctgttgtccttcttactgccca

1214 2610157 CRELD1 YES catctgtgtgaaggagcagatccca 1215 3092298 LEPROTL1 YES tggggagcttgtgcacttgttctcacaggaaacacagtcatctttgcaactatactaggctttttcttggtct- ttggaagcaatgacgacttcagctggcagcagt 1216 3241630 CCDC7 YES taaagaaaatcgaccagaagcagtgaaaagttg 1217 3489976 -- NO ctctgaggtttaggcctcgatattcaggagagtggtgtaggaggaagatgaaccactgggttttagacacatg- gaggcttagttcagggctttgggcctccc ggttagtttgtttagtcttgttgatctaggaggagatcacaccagatga 1218 3671050 PLCG2 NO ggagaacgtgccctattcacactctgggaagacgctaatctgtgacatctttctttctcaagcctgccatcaa- ggacatttcttaagacccaactggcatgagttg gggtaatttcc 1219 2476149 -- NO gtcagttagacagagtccacaagggagtcg 1220 2670672 -- NO gaactcacggtcttcagccttcctgc 1221 2792848 -- NO tggccatggtgaaacagtgcctcta 1222 3168127 -- NO ttccaatcagcagtatcatggattaaat 1223 3227785 -- NO gggcagtttgactatgtcgcatccagcttcccatgccgtccatccctaggagtctgtctcaccatacaagggc- gcagacaggccagcttgagggtgttcatc aacgcagcattgtttgaagagcagaagttagaatctattcattcgggggcctgactgcataaatacactg- tggttgccgtccagca 1224 3367153 -- NO cttgtatgaccctttgtctcggttgactagttgtttgctctaagaatatttcatgttttgctgtttctttcag- tttgtaggtgctaagctattgaaaggtttagagactaat ctaggtctttctaaattatggctgcttgcagttttattcctggagaaatggtttaacagcacttctttga- gttggcactcttctgcctgtctcagctctaactttcccgc ctccttttcagtagtccctctttcaccctccactccccaagcctgaaatggaaagaacttgctttgttac- tgatgataatatttaagctctaaaattttaacagtgttt cagttgcaaataaatggaaattgtgtattctgtttaatgtgtttcagaaaatccctgctatttttttttt- ctttaaatacaagaaaacaggcgtgtaatgcctcattgaa aa 1225 3483227 -- NO tttagtcaagtaggttgagagcaccagggatcattttttcttcacaaccttttagctcagtgatacccagagc- aatgtgcctactcagtggagaagatagtatttgtgt gaataaatttactgttctgtgtgttacatgtctagttaggagtggtcctctaattctgta 1226 3766878 POLG2 YES aaaatgtggttccttgtgttctctctgtaaatggggacctagaccgaggcatgctggcctacctctatgattc- taccagctg 1227 2555150 -- NO tgggcgtgaataaggaagcaaaactcaattataataacattactattgttcaaacttcacatggcacttgcaa- ccggaggctactttgtctgcctgtctccatact catgctgtcttatgctcatgttcttca 1228 2601747 DOCK10 YES gataccacttcccactcgtcttccaaggggggtggaggagcgggaggaactggtgttttcaagtccggctggc- tctacaaggggaattttaacagcaccgt gaaca 1229 2664745 -- NO ttatccaccgcacatgaaagagagctcagcgccaactgccagtccactgaagggtgtcgcagtgatatttgtt- tga 1230 2698409 -- NO atgtgctactaacaggtcaggagcccagatcaaagagctggtttgggaggtggataatgaaggttgtgaagtc- tgtgctccctctgagaagcctgaggaaa atgcaggtggctccctcaatcaacagacatccaaaatgg 1231 2704917 PHC3 YES atcagcagattcctcttcattcaccaccttccaaagtttcccatcatcagctgatattacaacag 1232 2823922 CAMK4 YES aaatgggattgtccatcgtgatctcaaaccagagaatc 1233 3717013 -- NO ggtctatatgtctgtacttatgctggtaccac 1234 3498270 -- NO atgtccagcgcaaggacactgtccagccttctcttcctgcacatcagctgcctcccgtcagtcctgctgaacg- gggatccttcccagatttc 1235 3737381 -- NO cttcaaagggtgtccagatgctatgaagcattgggttcgacttggggtccacgtggtttgtgcctcagggtcc- aaaaccacctgcattctaccggtggcgtct gcagaagacgaatggcttgaaggagctggcactccgccggctagatgatccaaaccatttcatttctttg- tcgtgtggaaaaggccctctgtgatgcacttct gttctctgga 1236 2512319 LOC643072 NO ctgtagctttgagtttgcaccgttccttgtcccaggaaaaagttaagaaacttaaaatgttttgttttgcttt- aaagaagacaggacagaaaacgggatttaaaa cttagtttttaaaaaaacaaaagctacagagtagggagcataggtcaaccatctccacctaaattttttt- tgttcctaaactcagaattctacaacccaactaaatt aatatgccaagattttgcggatgttaaaactcaaaaaaagcagtatgcaagacggtcccggggtaaaatt- ctactgcctttccacggacaagtta 1237 3596425 -- NO agtcctcgctgtagcatggggtaaagccaggatatgacttcacatagtttaactccagaacttacactgtcat- cttgttttgtttttctgttctcttgtgtgtcaaaa gaattcctccttagttgttctcatatggggcaaccattaaattaggcagtgtaaaaaacaagttatgcag- aataaagtagcaagagcaatctactctgaaattag tgttttccctcactttagcacctttagctgacccagcttcctaccgcccagactttttacaaaatctctc- tctggagttgcctcctgatctggattaggagtcacata 1238 3809494 -- NO ctgtgtttaacacggctgtgctacttcaggctcccatctcgctgagggtgcccatgtcagccaatgacctt 1239 2442446 -- NO gtcttttgcagtaggtcagggctaagaggactaatccctcaagagtgaagaaaaaaactattgatggtggctt- gaaagagtcaactgctgtagcttttcttgga gatgatcacaaaatggggagcagaaaacaggttgaaattacagaagattaattagtaagaaaagatgggt- taaagatgtaaattagaggcaaagttaagaa gaatttggtttcttcattatactcagaaaggtaaggatggaaaagttgatggagcaagattgtgaagtat- cttatatgcaagactaagaagtttggactagattct gaagacttaggagaaccagtgaagaaatcttaatagaggaatcggattagatcttagggtcagaacaatt- attagcaagcagggtaggtgaagttcctgttg acccactttg 1240 3281111 -- NO agcatctgtcgctggtgagaccctcaggaagcttcactcatgaggaaggcagtagggagctggcatggcttgg- cgagaggcaaggaaggagagggga aggctcttttccataagcagttctccctatggcaccaagccatttatgagggacccacccccatgaccca- gtcacctcccaccgagcaccacctccaacattg gggatcacattgcaacatgaggtttagaggggacaaatattcaaactgtatcactgggagatggggctac- cggaagtcaagccattcc 1241 3770080 -- NO ctgtactaagtgctgatgtgccagcgctatg 1242 3821078 -- NO acagatgtgatcaaaaggcctaatatatgtgtaattggagtcccaggagtgaagagtgaaaatgaggcagaaa- aaaattcaagtgagaatggctaagaattt ccccaaactgatgaaaggcatccacccacaaatcccaattttgtacttccaaccactgttataccacccc- cctcaacaatgcctataaatgtttgttgaaaatga gtgaatgaatgtactccaatcattttctcacttggatgttccctactttttgc 1243 2531265 SP140 YES ataatagcaaagccgacggccaggtggtctccagtgaaaagaaggcgaacgtgaatctgaaagacctt 1244 2719554 CC2D2A YES actggtggctcgatatgtgtccttgattcccttcttgcctgacactgtctcatttggtggtatctgt 1245 3342924 -- NO tgaggtccacaaatcagtcaagttgaataaagaggaaattctaaggaaaatattaaaaattacagaaagagga- agctggggacactgagcataaactttgat gacatcaattttaccgtgtgcctatccactattcctccacttagtttctcagatcttgccagcaacctta- gggcttgcatcctccatttc 1246 3811421 -- NO gtacgtgtgagtgcgctgtataaagtctggaaccacaattag 1247 2448106 -- NO ttgtgtgattgcaatgctgaatttgtc 1248 2661177 -- NO ccttgttcccacatcggcacattatc 1249 2748212 -- NO aggcattttttgtccacacacttgctttggggatttttattaggtagacggtaattagaggtgtcagtcatat- gaaagtaaatcactagtctttcgtattactgttttct cagtggtccttatcagttttttttgttgctctgtaatcattcatatggtaagacttaacttttagtcatg- taaatttgtttagggacaatttaaactattttgtcaaattagtc gttttattccaagttgtacgtcttatgcatttatttagtatagtgaaagccttatatacacatttaatat- aattagtctctggatatttggattattttttagtagtactttttta gagtgtgggttttttcttttcttttctgtttttgagacagtgtctggttctgtcacccaggctggagttc- ggtagcccagtctt 1250 3081649 -- NO cacctttgtgcatgtatatacttcaagttgtatgaatttctttatgcaaagagcctttaaaatataaactgtg- atttttgtttctaattttttactttggattgacagggcct tttttcaagtgttggaatttccttttagatttcttatcagagtttatcttgattttactgaaattcattt- agctatatgaaattcctttagccatagtcttgattcagatcccc ccacctgagtctttccaggaccttgtgccatctgttattgccattgttgtattcacttacagcctcttct- ccatgagtacaagcccaccatcatgctc 1251 3415065 -- NO gagccattcctttggcaactcttgctgtcagccatcttccaaagagctttg 1252 3436225 -- NO tgtctaccatgttgggcagcacagatctaaagcatttagaaccatggctagagctatgtgtttactatcattg- cttcaatatggagagtcatccaaacaggtttca tttgctcccagataaactgtcatgggacctgccgtggccagtgctcaccttgtactgctggaataattta- acaatttttttcaactgccatcatcatcatgccatttt atgtcttcgtagcatttatcactatctaaaggtaggtcgctta 1253 2546677 -- NO ctcccaaactcttgaggacatgtggggaactacagctgg 1254 2723423 -- NO aaggtagtgtgcaaagcgaaaagagggcacagaccaaaatcatgcaaaa 1255 3291647 -- NO gtgggttacatgttcctgcctggca 1256 3449366 IPO8 YES ggacctcaaccggatcatccaggcgctgaagggcaccatcgacccgaagttgcggattgcagccgagaacgag- ctcaaccag 1257 2935290 -- NO gttttacaacacccaaagcaacagaaa 1258 3296065 KCNMA1 YES gttatggtgatctgttctgcaaagctctgaaaacatataatatgctttgttttggaatttaccggctgagaga- tgctcac 1259 3414403 SMARCD1 YES tacggtgtactgtcctactgatgctggattacca 1260 3611215 -- NO ctagtctagggatagtggtagaagtacgtaatgtagatg 1261 2997513 -- NO cctttgctctctcatatgcatccggcacagcagc 1262 3180413 -- NO ttcaagggcataggcgtcggaattgtgatttcgtgcgtgttt 1263 3732510 -- NO gaaccactttgttgaccttctgctgcaa 1264 2572597 CCDC93 NO ctggacggtgtctatcaaaagtgcaaatgcataagctctttgaactagcaatgctactcctaagaattgtacc- tgtgtacaaggtacttgtgtacaagagtttttgt tgaaacattgtaatagcaaaaagttggagagtgccaccaatacaggggaatggttaaatacattatggcc- agcttaaacaatggaatagtttgtagaaatttaa aacaatggatcctgtgtgtgtgtactaccatagaatgggccccaagatgcatgattaagtgaggaaaaaa- gcccatggtatcctaatgtttggaatggagaaa gtgtgtagatgtatgtgtgtgcatatgttttcacacagacgtatacacgtgtatatcatatgtccacctg- catatgcctaggatgtctctgggaggatatctagca gcccggcagcctgaattgcctctgggaa 1265 3216409 -- NO aggttctgaagtcccaggcaaatgtaatagggggtaggcagaggacttacttagagagatggtggtgaaagtc- tcaaactgcagatttctagaacaaacag gttacttgtaagaagcagacagagatacttagatcagtaaaatacttctgtaacactagaagtgagaaga- catgagaacgttatctagaaactatcaagagga aatgactgcagaccaaaaatcctacgc 1266 3294290 -- NO tccacagctcgatttggccaatttcgagttgaaaggatggtactggacccaggcctcataagtagcttgtcat- caagatctctagtagccaaatcagaaaccc acaatgaagtaaagatcagtatgtcaaggaagacaagactaacggggtaaaaagccttagactagaaact- acatttagggggaaataaagcaaaaataaa aacctttcaataagtaacactagtttccagatggtactctagctcaggcatgagaatctgttcttaaaag- tgggacattatttcaatcataaacataatttactaga atggacatttggcaaagcaagtccattatccacctgccatcacagtcacttttttagtcaccagtgaagg- caagcctgaaggacacctactccaaagtgcttcc caaaaatttgccacaggggctgattcctactctgtttgaggcattcttttgtgctgaaagattgtcacca- gaaagacaactgaaagacaaatattgctgcttggg agcagttgtggcaccagtgtggctcccactgtagcaattaaag 1267 3446505 -- NO gtcttgtagcactcaaacctttgtctttcccacaagactgaaaactccatgacacaggaatatttcttatcct- gtgaacctttgtgtcataccacctatagtagtgttt agtataaaataaattaattgtttggaaatctatcctaaaaaaaaaaacctagattcagtaaaagctctgt- ggccaaggatgtttgtgttacagtgaacaccttcga gcacttcagg 1268 3616936 -- NO ctcatagcatggtggtctcgcagtagttagccttcttacatagttactggcttt 1269 3628351 MGC15885 NO cctccgttacccgtcagcccagcatccggctttgcttccataa

1270 2745112 -- NO gcaaaattggtctggtatctgtctaaattggtcaatacaagtgttattctggaatcatgtaaaaatcacttac- tttcataactgtttagaaccccaaatgttttcccttt gaaggggaacatctgtggaatatgattttgaatagaggacttctatgaaatatatttcaaatcttaaaaa- tatttttaatacttcctaaagtggtataggatttaccct cgctgactatgccttccatttaagaacagtcttgcatttgtggcttttca 1271 2824232 APC YES tgtccctccgttcttatggaagccgggaaggatctgtatcaagccgttctggagagtgcagtcctgttcctat- gggttc 1272 3101817 SGK3 YES agttctggtttcagtgggaagaagtg 1273 3129414 -- NO cctagctgtctgtcaggtagaatgagggtgaaggagatctaggatgcttcaggcattgcgcttgaacttaaaa- aacaggatcagcaggccctgacttcataa ggcccataaatacaaatgactagctccctttctcaaggtcattgaaaatatacagtagtttcagacatca- catgggtttgggcaaagggggcagatttccaagc taggtcacttaatggtatc 1274 3576514 -- YES gtggccgggaggcaaaacttctctatgagtggaaacgtttgaagaatacatcacccattacgattttgctaat- cttaggtttcagacaccacagacacattgatt ctatttggaaagatagccatcaatcagccagc 1275 3650814 COQ7 YES ataaagaaatttcgggatgaagagcttgagcaccatgacataggcctcgaccatgatgcagaattg 1276 3723777 -- NO gccaaagagcatgtagagcaaactaggctctattcagcatttccatttcttaatgtatctatttgatttcaat- aaaatttcatcattttgaagatctctcccattagctt gggaaactacagaaacatgcacataactactgagaaggtatcaagtgttcctacactagtttaaaaaaat- cattcaacacccacataaattctgatatgcacta ggctgaacagctgttaaccactgagaagctgggcactgcatcctctccctgggtcaaaactctatatgct 1277 2550931 -- NO atgcacatgggacagtctaagatggtagtggtgg 1278 2681842 -- NO accaagtgacattttgcattcagcctt 1279 2868846 -- NO gctctagtgccacaggaagctgcct 1280 2880139 PPP2R2B NO agccaagggagaacccaagacagagaa 1281 3309073 -- NO attgaatgattgtttagaggcagtgtga 1282 3636536 HDGFRP3 YES gcaattcagcaacagagctcttcagaa 1283 2347802 RWDD3 NO gggatacattcaggtctcagttgttgaggctgttgagcagcaatccaggtatgaaaatgggaaagatttgact- gcttctctcatgcaggggaataaagcaaag gc 1284 3202177 PLAA YES tcctgcacttgacattcttcggttgtcaattaaacaccccagtgtgaatgagaacttctgcaatgaaaaggaa- ggggctcagttcagcagtcatcttatcaatctt ctgaaccctaaaggaaagccagcaaaccagctgcttgctctcaggactttttgcaattgttttgttggcc- aggcaggacaaaaactcatgatgtcccagaggg aatcactgatgtcccatgcaatagaactga 1285 3945822 -- NO aaggaagcgagagacttggcagtcctgtaggctttaatggaatcagcaatggacgctcg 1286 2682207 -- NO ggggctttaattcttaatcgctgtgaggattgttatccgtgggatgtgagctgtcttagtggtattcaatcaa- gtgtccacttagccatgactggaagtaattgctc ccaagtgggcc 1287 3263773 DUSP5 NO agccattacgggagcacagcatgtgctgactactgtacttccagacccctgccctcttgggactgcccagtcc- ttgcacctcagagttcgccttttcatttcaa gcataaggcaataaatacctgcagcaacgtgggagaaagaagttgctggaccaggagaaaaggcagttat- gaagccaattcattttgaaggaagcacaat ttccaccttattttttgaactttggcagtttcaatgtctgtctctgttgcttcggggcataagctgatca- ccgtctagttgggaaagtaaccctacagggtttgtagg gacatgatcagcatcctgatttgaaccctgaaatgttgtgtagacaccctcttgggtccaatgaggtagt- tggttgaagtagcaagatgttggcttttctggatttt ttttgccatgggttcttcactgaccttggactttggcatgattcttagtcatacttgaacttgtctcatt- ccacctcttctcagagcaactcttcctttgggaaaagagt tcttcagatcatagaccaaaaaagtcataccttcgaggtggtagcagtagattccaggaggagaagggta- cttgctaggtatcctgggtcagtggcggtgca aactggtttcctcagctgcctgtccttctgtgtgcttatgtctcttgtgacaattgttttcctccctgcc- cctggaggttgtcttcaagctgtggacttctgggatttgc agattttgcaacgtggtactact 1288 3497166 -- NO cgccagcataccagctcatgtttcagaatttctgtcacaaaaaggaacacaatattttaagttgactactgtg- ggaaagctatgatcattcaataacctacctttct gatagctctttctcagataatataagctataaaccaaaatagtcagccttcacctgatttacagtgccct- ttgaaacttcctaagttttctagcccagtaaatgctga gctaccagttctacttccaagctagagaacctgtttactaaagttagaagtctagtgacttcctctgtca- gactgtcccagaatgctctccctacccccaacaact gtgtaagaaccgtcattagccatctccaaattgccaaagtgctcagtcccttcg 1289 3618874 -- NO gtaacatgcatctgtgtgggaacct 1290 3202840 -- NO tttcactgctactgcgaactggtcctgaaggtgcagatctcttagaaggaggactcccacttcttggtggtgg- tcctctttttactggatgtggtcccctggaag aactcatgttaaaattcatggaatatccaccgtcatccatgtgtcctccccgtgagggaggtccccttgt- tcctccacttcctcctcttccacctctaagacctctt ggagggcctctacttcttggaggtggaggcggtccacgtctaccactttcaaatgatggtttgttggctt- gttccacctcgatggcttttccatctaatgactttcc attcatgtctctggctgcatccttagcatctgctgggctttcaaaggtgacaaaagcaaatcctcctgat- ttgttggtttcatggtctttcaccaagagtacttccac tattcgtccatatttgccaaatactgcttcaagagctttctcatttgtttccgtgttaagcccaccagtg- aacggctttcctgggcaatctgc 1291 3755656 -- NO cattaggggaccctgcctgaatctttgccaacctgcaaggaaactc 1292 2469949 -- NO tgccagtgacatccagggttattcgtatacctcatgctttagattcgcttctggttcatggtgccagccctta- gaaactctgggttcctacctgaagccggtcttat caaaacgccacccctggttccagtttgatcagggtaaccttgtgaattagcaagcagcagtccccagtgt- gtgctgacatggaggttggagagaaaatagat atgtcccatgcctggtttccagccaatactgatgtcgcgggttagtccagcaggctgaggctgaggcctg- tgacaaagtccctgcatggaggtcttcctgcgt cagagcctagccctgttcaata 1293 2830605 -- NO gagctttctaatgggggtgggaaga 1294 3235906 -- NO ttggggttgatacccatcatcgctcttagactcggggttgatactcgtcatcgctgttacactcagggccgat- acctgtcatca 1295 3616555 -- NO aggcagacatcaaccctctaagacatttttttcctatcctctgggaatattactttttggacaatcttggtcc- attggtaagctcatgggaatttgtcagagtttttttg tttcttttggctcatgtttagcatcgattggcagagtgtttggagtcatcc 1296 3369121 ELF5 YES caggaattttggagcgggttgaccg 1297 3908978 -- NO tcccatcagcaacatccgtcataccctgacgccc 1298 2338495 -- NO aagagcaggggacctatgatgcagaaagtcctttgctggagctcacaggtcgaatttcagggaagctgcccaa- gggcttgaacatccctgctttcaggttcc ag 1299 2452931 -- NO ccacatagtacggtgtataacaaggagtggtcaaagagttgtggctggtggtttccttggcaaagccaaagtc- agtgagtttcaggatggcgttgggcctttt ggaggtgtataagagattctc 1300 3448040 -- NO tgttaagccttcctgagatcacaccaaatgtccttgatgggaattgtaaacaacccttacttctggtttctaa- tgatattccaggaaaggagcctaactagagtca 1301 2823916 CAMK4 YES gattgtggaaaagggatattacagtgagcgaga 1302 3799998 -- NO gggcatcaagaatttggacatactggtgtctggtatcgaggttcttcagctactcaatgcacgtgatgatggt- gatgatcatgatggtaacaacagac 1303 2978095 SHPRH YES tcatgaatattggatggctctgaggaatcgtgtgtctgctgttgatgaacttgcaatggctacagaacgacta- agagtgcgtgatcctagggagccaaagcct aatccgcctgttcttcatatc 1304 3475634 -- NO gacacctcaggtgacatgctttatagttggcctgagccttgacccagtggttcaacctgagtttggtcttggt- accattcaggtgtttgtgagctgagactgatg agtaggaacaggtgttttatatctcgtcttttgtcaaaagtaaagactcattcctttggtaacccaacca- aatcaggatcag 1305 3683092 SMG1 YES gtattctgagcacacccaactacag 1306 4022048 RAP2C NO cgccaagtctctgggctattttttatttttgcaaatgtgctttctaatagccattgccaccatgttgtttacc- taatcagcatatttttgtctgaatacttgaacattttaa cagtaacgcaggtgtagaatcagaaaggaaacttatgcagagtaatattttggttcagttttaacatcgt- gacaatgagggctttttctagcaatgatttttaaatt gtgtaagtttgacagtattttattgttgggtttttatttgattttagttgtgtgcttttcatttgcagaa- gttagtaactgcagctcacctactgcaccaaagttctcgattt taggagcccagctttagtcatttgaacatgcttctaaataaaataaaacaaaaccaaaactatacttttg- atctataataagagctcaataactttgtcaaggaaa gctctaatatatgcagtgatggtttatgaaagggtgtggcaattttaaatttatattgtgtgtgatgttc- aaataaagtggtatctacattcatgtgatttatgggtca gcatgaccattaattactgagtagaaattgactaaactttgatttcctttttttaaatcgtgttgcattt- gattcctgagcaaattccctcaaagtgaactcttgttctta aattttgaattttatggtgagattgtaaagatagaggcaattgaaacattgttccttatttatgaactgc- ttgaagtgaatacttaatttaagtttgcactttaatacca aacttaaaaccaaacactcatttaaaagtaggttaagtgatcatggatcattgttattagctttgtggct- ttgtgaaattctaaaggaatcaaataattcatcatgatt taaattttctagagattttgatttttttataatgtttctttcctgtagattgtgttcttgtttctctctc- tctctctctctctctctctct ctctctctctctctctctctctctctcaaaattacagtgttcattgtcattgacc 1307 3153356 -- NO ttttctgaggaatagggctcaatggtgggcttagaatattgagtacaccatgctgtaaacagatatgctgtca- tctaggctttgttgtaccatttagagagcacag gca 1308 3529618 PSME1 YES gtggatgtgtttcgtgaagacctctgt 1309 3830025 -- NO aattcattcgcctccggtacttgcaagcctcgctcagtcttaagcaagaggggatggattcgcccgcagcact- gagaatccaggggcaggcgggatggcg ttcaggcgctgttgctagaaatctctgtctttactctgttttgaaggcagcatggcagggtgaacacaag- cacagactgaaggcagcttgccgcggttcacat cctggtcacaccacttcctgaccatgtcacgtgggcaaatta 1310 3866580 KPTN NO agggatgatcccattccaccctgtccactctggatgagaattggccacctgatggttatttatacgtccagaa- gaac 1311 2620390 TGM4 NO gccacctgctgacgacccttgagaagctgccatatcttcaggccatgggttcaccagccctgaaggcacctgt- caactggagtgctctctcagcactgggat gggcctgatagaagtgcattctcctcctattgcctccattctcctctctctatccctgaaatccaggaag- tccctctcctggtgctccaagcagtttgaagcccaa tctgcaaggacatttctcaagggcca 1312 2693884 -- NO cagtctgagttcctgcacccttcag 1313 2724817 -- NO gatgatgctggacaaactgcaaatcctgaacttagagactgttgcagcaataaccattttgactgtgataata- tcattctgctcaagttg 1314 3718581 SLFN5 YES ccagtgacccggaaaaccttcatgaaaaacaactttgaacacatccagcacattatcattgatgacgctcaga- atttc 1315 2645299 -- NO ctggcagcctgctcaacactttaaattttatcagtttagtacctgctgatgcgtctaaaactgttggtcccat- tctagttttatacttacatatgtagtattaaaagcac ttaagagaaatgtagaatatataatctttataaaagtattaaaggaattatttaaattgaatttgtatcc- catttatcttgcttgctaaatagatttaattggagcatcca tttgtataacgtctggctatttctacaatgttaaaacagtgggttgaggaagtaaaatttgagttactca- gttactgacatagaaaagaaccctgtgagaccaaat tcagctttggaaacaatttagtgtaattattttgcatatgtagatacacctttgaaagccaagaaaggtt- tatgattggatctgtactatattaatttaaaaacaaatta ttcttaagtatattgtagcatttctgttcctgtaagtactttactcatcttaaatgtactgatcattagc- cacctttataaaaagaatgtgcctgacccactagtatttga tagaaatattaaaacagttaagatccttaaacatttctgcatataattttttattgagtaaatgtaactt- aacgtaagtagttctatgaagtctgtgtaaattaaaaccc tgttttgtgtagatgaagcaatctttataagtttctgtcatcaagactgtattttgtgtgctatttttcc- atagctaggaaggtggcaagtaaaacatatgcactatcct agaaacatactgttccaggtagatcttaatttactacctggaatgagccatcttaggtgaccacca 1316 2927067 -- NO aatctgtagttgtaatgtagccttctacctaaataaaagagatcctaacataatggttctcattacttaagcc- tcattatgatcaagctcttcccaaataatctgacc aa 1317 2434911 -- NO ctgagacgatgattagtagaactgagaagtgcccattggttttggtgagatagaggtcagacattaccttagc- actttttggg 1318 2916250 C6orf162 YES ggctcagaggggtgcgcacaacaaccttat 1319 3152957 -- NO

tctggcaaaacccaggtgcggtaaccctgcagcagcttccactcactcctgcaatgcctgaca 1320 3190622 SPTAN1 YES gaagcttttgagacagacttcaccgtccacaaggatcgcgtgaatgatgtctgcaccaatggacaagacctca 1321 3508990 -- NO ggatttctatgccacactacccgtaactttgaaaaataactttaggctgcagttttcagcaaacaggacagtc- cttagctgccacatagctcaacataaagtgca caaaaaacttcacggtgggacagtgaatcataaattcccaaactgacgtgtgtctacagaacagatg 1322 3567717 -- NO ttttccatagcttggttctcaggggttatagatgcaagaagttcctggaaagagctctaaaccagaaaataac- agtctgctggtcaaactcaaaactgtcttggt tgatatatgagctggctgtctttactgttacctcctgtcatgatcattttgctaattttctgctataact- agaggggaatgtc 1323 3780094 -- NO tgcgttagaagacctgccgacaggccggataaggccaatgagagagggaacggagaagaggggcacctgggtt- cacaggccttaagaaagaatttagt tacttatttaacaaattaaacaatgtgtgtcacgcatgtaggtctgggaaatgcattattaaaaacacac- agtgcagaggtgcagcaccagcatacgggtgga tt 1324 3799938 -- NO ggacaccctcaaccagtaacacacactctccttcttcaatgacgtttgtgttcctagaatccattttcctcag- tcag 1325 3932154 -- NO tcttgccatacccaagtagggaatcacttccaggaaaacaagtcctcaagcactcaatgactttgtaaaccca- tgactgaaacaagactcatctgaggcagta ggactggtgggattctactgacttcttagtatcacatggcaccatcacaaatgcattgttagagcagcaa- catccagagttcttaagcttgtaccctaaca 1326 2534308 -- NO cctcacagtgacacgcgatgttttcaaaagtccatctttccacaggatgtttacagcacccagcgggtaggca- gtgctatttattaaccctgttgtactgatgaa caaaccagccggctcagggcagggggtgagcttgatcaagatcacagacaggaagtgacagcggggtctc- agcccaggccatgcctgacacccacac tcttctctggtgggggcgcttccacctttgtccctggaagcccagcctgacagcttctgcagtgcctctg- gcagccgcccacaaacccagccaggcaaaat cccagggtgccagacaccaggagaaatttccaggggaatttggccatttggctgtctcttcacttccctg- aaaagccaaacagagaatggatttcttatcaca ctgtagcaaggcaatcaactggaaaagagacaggaggagaagtgtgaggaccaacagtcacagggaccca- ggaatcgtgttagccaca 1327 3696944 -- NO gctcccaaggcccaatcagatacagctctccaaacctgccagtgctggtgaacgcgctgctgggagcact 1328 3712853 -- NO ggccgtgaaggaagaatgcggtgtt 1329 3916807 -- NO ttcaccaggatacgactgttggaccagctgctggagatggacctgctacccctcagcagcctccccaccacaa- gacaagtgatctcaatgtccccaaacct gtgggaccctgttctacacacctcatttttgttccggcgtttcatcctccttgtgtgattgtactgattt- tcatgagacacaagttacttctttacatccatattcccaa agcagggttacatggtaggaaagaaaggaagttggaggtactaagctcattgtgtctcctc 1330 2381295 -- NO aggaagtaactagagccggcatttgggggtgttgcggacgattcttacgaatccagacaatttgctcttttaa- acgcggccttgcggttgtctaacagtgaga atagatgactaactgaatttgtcagactccctgccttctgtcataataacgacgcagaattgccaccgtt- atgtgtc 1331 2608169 -- NO gtatggggagaacgaggatgtgata 1332 2363544 -- NO ccacaagaagggctagagaaatacagagatatttgaagagtgtgaggaagagtattaacacaccagttttctt- gatcaatag 1333 2407863 -- NO acatccttcttttcggccttgaatcctttcttgctttgcaaggaacaattttcttcctactataaactacagc- actaaggtatggaccttagaaattatatagtctaatt ctctgctgacacacaaatcccttcaacaacaaagaatcataagttcacattgaaaggtctctccaaatct- cccataaatctacaatattcttgatgtttaaaattta ggataatagagaattcactaattcataagacaaagtaccaatgtaataattctataaaatgtcataatct- gctttccttgtaacttctgcctattgactc 1334 2920969 FIG4 YES aggatcctcgggcttatttcgagcggtttcagcttttggtg 1335 2949119 LTB YES tgcgtggtgcgagtgcgtgaatattgggggcccggacgccca 1336 3241194 -- NO cattgggccttccatcatcagaaagctcctcatgccacatcttgacacattattcccgtcctcctg 1337 3447084 -- NO aggatgtgagactgccgtggatatcagggaagggagacttataagaaggagaaatttggtcaactgtgtcaaa- tgcttcagcgatcaggatgagtaatgag gaacggccatttgatttgatttgatcattcagatatctttaaagacctttaagagggcagtttcagt 1338 3626136 -- NO acgaccatgcgcactgagaaacaggcaccaggatgtcgagaacggcaatgtatttgctcacaaaaagctctac- ttcacacaccacctgtgcatgagcgtgc cacatcaaaatga 1339 3800039 -- NO cataatcaggtcctctgcaagtgggagtccaactgtgacgcagcccccccacgttcaaagcatcccttcagct- tccggcaatctcctctccagg 1340 3887175 -- NO gccctggttgcaactctgctggtct 1341 4011861 -- NO atgaggggaacggtagctgacaatagcagaggagggttttgcagggtctttaggagtaaaggatgagacagta- agtaatgagagattacccaagagggtt tggtgatggaaggaagccacaggcacagagaacacagaatcactttatttcatatgggacaactgggaga 1342 2320367 FBXO44 NO ggtacaatggcatggcttctgtctaaggtacagaggggttggcatttcaggaaccaggccatcacagaaacag- gttcatgggcagacccctcagtgagctg caggtatctcacctggcagccgtccagtactgctggcttcctctggaggcccagccacaggctggggttg- gggtgtgtggacatctctgggcagctcttga gtccaccttgtgccagatcagcagtgccaccc 1343 2680360 -- NO gagctgggtcagttgctccattatgtactttggtttgcag 1344 2866718 ARRDC3 YES actcgctacctcattcgaaggccgacatggcagtgtgcgctattgggtgaaagccgaattgcacaggccttg 1345 3251759 -- NO gacaaccttcaatgcactggtactttgtaccctgacctctactgtgatgaacactcaacttgggcaagga 1346 3742688 NUP88 YES tgtgttgagttggagcttgctttgaa 1347 3772092 LOC100131096 NO tggctgtgcctctcgatgatgattaagatttcaatatttacagcaaaaccacaaagcaaatgatagaataaag- caaaacaatggaaaatctgagttcactcgtg agagaggtacgtatgtgagctctgaggaaattacagagggaacgcatgcagcgggacagctctcccaatc- gcagcgtgcaaagtagacatcca 1348 2596545 -- NO gacagcagagctatctatcagttcctctgaacttgttctgaatgagcttttcttactgttcagtattcactct- cctattactgttttgcttcctcatagaattccagatta gtgggcccctggaagttcagctggtagatgagaaaactgagcccattgaagttaaagtcacccagctagt- cagggttgatcttcccaactcagagtcccctg cttacttaaacttttatatccaacaggtttacttcccctggaaacttatttggtattttttattttccat- ctccatgccctcgataggtttc 1349 2928626 -- NO cagccgccaaagacgcctgagagcggcaggggagtgtgttgccttaggacaatagcaaactgggacgtggtag- agtctgtaaattccaagcactggg 1350 4035053 -- NO catggtatcatgtgcctgtaatgtc 1351 2487210 ANTXR1 YES cagggtcaagaacaaccagccagcc 1352 2891955 -- NO ggcccttgacaaatgcctgaaatct 1353 3061185 ERVWE1 NO ctcttcaaacaacaaccaggaggaa 1354 3104349 -- NO atggacaagttaggccctccacttcgaacgggaagacttgtgcaaaggttgtatgacagtgatacaaaatcag- acagtgcc 1355 3915245 -- NO aattgggttcttgaggtggattggaggagaacagcctctggatgtctgctgggcagtgacgatgtgtctggag- gctttgacattggattcattaggcattgcta atgtacacaaaaaatgtagcaaaaatgatgcctgtttctgggtgagaacatctg 1356 3961553 -- NO ctcccaggtttacaggtcttgactcagtacttcatcagcaataggttgtggtcacaggaaatggaagctgcct- caggacctgtagcaacttgcctgcatgctg ggttatgttatcttttgagtggtgcccaatacgaggtgtctaggggaaagtcttaagtggttggagccca- tgaca 1357 2523501 NBEAL1 YES tctcacagtggaattcgtccctttctt 1358 3601127 -- NO gtgtgtttgtgcaagcatgttaagcatttctctgtcttgtgttcatt 1359 3892321 -- NO tgcaggggtgtccagacggcctggtgcaggatccctttgatgtggagga 1360 3087823 -- YES ggaggatgttcggactatagattcagctgtgggatctggttctgtagctgagagcacatcgctaaacatagat- gtgcagtctgaggcttca 1361 3337295 -- NO aaggctacaactgtgctcttagaggcaaaagaagaaaatgagactgccaggcatgaataatgagaaatctttg- atggaattagccatgcagaacagata 1362 3528558 TRA @ NO tctttggtcccggaaccagattgtccgtgctgccct 1363 3536444 -- NO cttttctctgtagttggcggaatcagctcagttacattttttactaagttacccacattctgacactccttga- cagttttaagatcttcttctaacacacttgaatagaat ggatactggaatctattttgacagctgttgaaaatctattctgttgttacaggaggttaaggaggttatt- tgtaacactgggattatttaatgaaccttttgaaaagg tgtgcagactgttcaggcaaatagtattttttagaatttaaatgattttggttttcacagttaaattatc- aaatgtaatgcttttaagaattatacacctagtaatatttttc attaattttctccaccagtgtagtaatagtacattacaatgttctcaattaccggtgccttctaaaatgc- aggtgtagagtctttaaatacagctagtctattgccag ctgtcccatagataaccttctttaaaagtgacctttgagcaatttcataaagaataaatatttctagttt- tttgttgctgaactgctaaaagatggttctatacatgt aacaggtggctttagttgggttgctt 1364 3823557 RAB8A YES atggcgaagacctacgattacctgttcaagctgctg 1365 2707806 -- NO cagacccttgtggtcgagttgtttactttggtaattaagtacctgactctgctggacgctcttcgcgtttcag- aagcgctgtttggcattgtacagtctgagcgtga gttgaattcc 1366 2849541 -- NO gttcttcataaatcctccactcacaagcttgcagcctttcctatcacagtcatatccaatctcaattcccctg- cccagtataatgggactcga 1367 3795889 -- NO acgctgaccagtgaccgaggacacagttgtgtgttaggctccatcacctgctgtactttgagttgggaaattt- tcatcatcttagaaactgggtcattttatcaga gtctagagtcagatatagaaaaagtttgtggctatttctccaatttatatgactaaggtcgggtatcttt- ttcaaagtgtctaattgaaattgaaaaggcagcaattt aaagttgctattgcaagggcagaaaatggtcttaagaaagccagctttcaaattgaataaacatgactgc- gttcactttttgagc 1368 3895772 -- NO gaaacaaactgacaatactcgtgaaatcaacacccagatgaggtagaccagcactcca 1369 2920915 -- NO ccaactcacaccatagcagcgctcatt 1370 2971825 MAN1A1 YES ctggaggcagcagtattctggcagaatttggaaccctgcatttggagtttatgcacttgagccacttatcagg- aaaccc 1371 2990655 -- NO ggtttcttgataactgctccacttagagaaatgagctgtgatctgtgtagattttggaaaatgggtagctggg- gggatcatctttaaacaatctttttcatgctcatca cgaaatgcttttacaataggtttattttgactttgtgtttagaatttttttttttttttgctttttgcta- tagactctttaaaaaagttgttgttctggatattattgatagatgga acaaaattcatgtccttgcttgaatcttttagcgagctattcagagattctatatccccatttactcatg- gttttttcaaggtgaatgaaacaacataccctgct 1372 3198975 MPDZ NO tgcactggtcctgacaatttttatgctgtgttcagccgggtcttcaaaactgtaggggggaaataacacttaa- gtttctttttctcatctagaaatgctttccttactg acaacctaacatcatttttcttttcttcttgcattttgtgaacttaaagagaaggaatatttgtgtaggt- gaatctcgatttttatttgtggagatatctaatgttttgtagtc acatgggcaagaattattacatgctaagctggttagtataaagaaagataattctaaagctaaccaaaga- aaatggcttcagtaaattaggatgaaaaatgaaa atataaaataaagaagaaaatctcggggagtttaaaaaaaatgcctcaatttggcaatctacctcctctc- cccaccccaaactaaaaaaagaaaaaaaggtttt ctaatgaaaatctttaaaaaatactgtcagtattttaaaattttcaacagtattataaaaacattgcatc- tccccacctctaatatgcatatatatttttcctgctaaaatt ggtttctacaattgagtaaatggcaaatacatgaagcaatgtccctaaattttataaagaaattatattt- aatgcacatttcaattttcattcttattttgaccttttgta aaatattttcatgttgctataagtaaatgatgatgccaccccatgttgactatggtttttctagaaagca- actatgctgctaaccatagaggaacatagaagggtt ccagaatctttagtgctggttttaacaaccgatgcaacattaaaaatgtgttagtgtgctgtgcaattgg- ttttcaattcatattaatcttaatgacagagaacaatg tgttactaattattttggttgtatgccattagtaaattgatagaaaaattaaggggattaacataacttc- atttcattgacttatattaacatcttataatacaatagttta agactaagggaaacagatggagctgtttattgagacaactggtga 1373 3652974 -- NO ctgacatggtgtgtcacaaagagctcc

1374 3680296 LOC388210 NO gtagaccctacaccattcctcagcc 1375 2530462 COL4A3 YES ttccctgggttaatgggtgaagatggc 1376 2550272 -- NO caggggcaagagctagttagaaaactgagctcgccctgtctctaatgtctggtgagctgctctcctctctcta- caatatatcacgggtagtttcatgtcaacaaac 1377 3118585 -- NO gaatatgttgttaagtgggcagcat 1378 3403090 C12orf57 YES taagtttgctcgcttggtcaagtcctacgaagcccaggatcctgagatcgccagcctgtcaggcaagctgaag- gcgctgtttc 1379 2524930 -- NO tgtgaacttgggttgtgtcgtagaaaatgtgagtgtcagagag 1380 3125787 CNOT7 YES ggttacgactttggctacttaatcaaaatcctaaccaactct 1381 3171102 -- NO ccaaggactggcaggacgtcagtgatgctggg 1382 3250113 KIAA1279 YES cctgagcatataggggaagatgttcttcgccctgccatgttagctaagtttcgagttgcccgtctctatggca- aaatcattactgcagatcccaagaaagagct ggaaaatttggcaacatcattggaacattacaaatttattgttgattactgtgaaaagcatcctgaggcc- g 1383 3747008 -- NO ggtgactggaccacgcaggtagtttctcatgaatgatttagcactgtccccctactgctgtctcgtgatagag- ttctcatgagatttggttgcataaaaagtgtgt agcacctcccctctcttttcctcttgctctagccctgtgaagatacctgctctggctttgccttttgcca- tgagtaaaagctccctgagacctccccagtcatac ttcctgtacagcccatggaaccatgagccaattaaaccttttttctttataagttacccagtctcaggca- tttctttatagcagtgtgagattgaaccgatacagac aacaataacaaaaagtagataaatatgaaggccagagaaatggcaacttcttcacgaagggaagctgctt- atcctcaagcaagtcagttgaggactatcctg tgagctattttccgtgccttgttttccactcatacagggaagtatgccctggtgtctcacagttgcttca- gttcttctttactgggaccctaaatataataacacact gaaccactcaacttctcagaccttcaatatccctggggctttttctcaaatggacacagcatagctttca- gaaagctgaataatgtagacaaaagaagtctccct caccctttgattatggaaaaccaaagatttattcagtgccaaggataagaaaggaaggacttgatcaaca- accactgttaagattttgacccattcactacttca cgtgaactcccagggaaatggaaaatgaaagaaggtctccgcggtagagggataacaatg 1384 2406715 -- NO acagagccctgattccacatacatgagctcccatgtgtggctggggctctgctgggtcctgggggcaggagga- ggatggagaggcaggccctaccatgg aggaggttgtgatctaggggcaggctcctaaccagttaacatgtgcacagtttggcaagtctctcacaga- agtctatagcatgtgggggaacccagtggaa gaagtgatcgagctctaggatgaggaggagactggggagaacttcagagagcccttagaacttgaactgg- gactgggcac 1385 2808962 ISL1 NO cctccttggctgaaagagtcctttcaggaaggtggagctgcattggtttgatatgtttaaagttgactttaac- aaggggttaattgaaatcctgggtctcttggcct gtcctgtagctggtttattttttactttgccccctccccactttttttgagatccatcctttatcaagaa- gtctgaagcgactataaaggttttgaattcagatttaaaa accaacttataaagcattgcaacaaggttacctctattttgccacaagcgtctcgggattgtgtttgact- tgtgtctgtccaagaacttttccc 1386 2849483 -- NO cctgttggtgtgtcgataatggcaaggtctgcagtgacccagcagtggctgaggtggggctggggctgagaac- ctgatccctgagaggccatttattgtaa gaacaggcaacatggcagggaagtgaccaggaactaggacaggcagtaagtgggagagaatgacggcaag- cctggagctgtcccagaggtgactga cggatgctgtacaaggtggaa 1387 2868168 ERAP1 YES atttgccctacagatggtgtaaaagggatggatggctttgctctagaagtcaacattcatcttcatcct 1388 3082899 ARHGEF10 YES atggagttcgagtgaatttgaaagttacgaagagcagagtgactcggagtgcaagaatgggattcccaggtcc- ttcctgcgcagcaaccacaaaa 1389 3505964 CENPJ YES gctgagaacgcatctttagctaaacttcgcattgaacgag 1390 3522535 DOCK9 YES caaagctaattgagccactcgactatgaaaatgtcatcgtccagaagaagactcagatcctgaacgactgttt- acgggagatgctgctcttcccttacgatga cttt 1391 3404455 -- NO cactagacagcaattcagagcctccaaaataaagaatattcataaaagtaacaatagaggtaaatataaaacc- cagaattactacatgtgtcatatagtttataa cttctcctatttatagctttctatatttatatttatctataacttcataggcaaatgaataaaaattata- aatatgatagtggtcatataatgtataaagatgcaatctgtg acagtcttatgaagcagggatgaagacatataggatcaaaatgtttgcatagttattgaagctatgttga- tattatgaaattatattgttacaagtttaagatgctaa ttataattctcaaggtaaccactaataaaattaccaaaattatgcagaaaaggaaaaaagaaaaacaata- cactataaaaaaccaattaaatacaaaaaaagtc agtaacagacaacttgagaaacaaagacatataagatatagagaaaacaaatgattaaatggcaaaagta- aatcttgttttagtaatcacattaaatagaaaag gatgaagccatcctattaaagggctgagactgacaagttggctaaaaactaaaataaattaaaaagaaaa- acaagactcatctacatgctgtctataagagac ttgccttagatataaggacacaaagaagttgaaagtaaaaggactgaaaaagatattccatacaaacagt- agtaaccaagatagtgccgagtggctatattttt gtcaaacaaaataaactaaagtaaaatttacaagagaaaaagaagggcattatgcattgacaaaaatttt- gacatagccaaataattatgttataaaatatatgt acttaataatacagcctcaaaatatatgaagcaataattgctataatttaagggagaaaagaacagttct- atgaaaagttagagaatgaaatattccactttcaac atgagattaaacaactagacataagatcaataaggaaatagaaaatttgaacaacactataaaccaatta- tcc 1392 3309338 -- NO ttccagctcatcggcgttgaggtgcac 1393 2475878 -- NO gctgctgagtctcaaaacagccaaa 1394 3032635 -- NO gaggctcctcttcctatggatttgcttcaaggaggtcagggc 1395 3475556 VPS33A YES attacattgaggattgtatcgcccaaaagcactcgttgatcaaggtgttaagactagtttgcctccaatccgt- gtgtaatagtgggctcaaac 1396 2930679 -- NO gatcaacattcttaatgacataagagaagggagttgcaggtggatctaagggaaaactgttccagtagtaaag- gagcagcaaatccgatagccctaaggga 1397 3489376 CDADC1 YES ggatcataaaacaggagttggggcag 1398 3933755 -- NO gtttgcatttgaccatgtcgtgggcaggaga 1399 2430088 -- NO tcattcttaaggctaaggtggcaagataa 1400 3420474 -- NO atggaagcatgttggcgtcatcagcagagacagggaaattgggaaggagaggagagcataattagtgtgcaga- aacttggaaatgctgacattggactcc tggcaga 1401 3956302 PITPNB YES gactgtccccagatgtgtgcctataagctggtgaccatcaaattcaagtggtggggactgcaaagcaaagtag- aa 1402 2334264 hCG_1820661 NO ctgctcgctgagatagacacatacctgattgcctcctttggagaggcttgtcagaaacaaaataatgcaacca- tttgtctctcagctacctgcgacctggaagc cccctccccacttcgagttgtccccgcctttctggacggaaccaacgtacttcttacatatatcgattga- tgtctcatgtctccttaaaatgtatgaaaacaaactg tgccctgaccaccttgggcacatgtcgccaggactccctgaggctgtgtcacgggcacgcatcttcaacc- ttggca 1403 2358760 SCNM1 NO cagcctggtgccctattaataagactgtcaaaaagaggtctttgcccttcatgttgtctgcctgcttctccac- taccactcaaagtcctttcccccttcaaatcaca taaggactgcaggtaggcactagggggacctggccacatctggaaacagggctgtggctaagttccctgt- gaaagtagaagagtcaaaaggcattggca gggttatggggaacaccaagggagggaacacccccacctcctcctagtaacctgaacctccctgcctgct- gatccccagagtataaataatcccctggtga actggcagtaacccttgggggttagcgccaagattctcaccccaaagcccaaggaaggaggcaggcaaaa- tggatagaagggcttttatttacaggaaag gaggacagatgaggatttaagtgtccagtgctcccagcgctagttggtaaagggaaatgcagtgttatct- cttcttttgctggcgacctgtaa 1404 4005886 CASK YES tcatcacaaagcacccagaccggtttgcgt 1405 2440191 -- NO ctcctcacccgcatcataactcctcttcaag 1406 2561968 SUCLG1 NO aactgtggaatggatcacgtagacatgtaacccagcagcagtttgcttctgttgtccactgattaatcagcct- atgtgcctgacactggtcttgca 1407 3216427 -- NO atgttgagaaagcatatgcatgtgacagggcggatttgttagaagc 1408 3235909 -- NO gttagactcggggttgatatctgtcatcgctgt 1409 3469137 -- NO agcaacagaaagctcgtggtgttcctctgcctcaaaggccaaacgtctgtgggttttttgtcttggctgccga- ccgcagcacgtcacactgtttgaaatttgca gctgcgatcatttatcttcaggggacaggggt 1410 2343471 -- NO gacagattgaaagaggtggtgaagc 1411 2464386 -- NO ggtacacacattaggagactgcagttttggtgagaggtgatggaagctcgagactagtgaggaaaagggaggt- gtcaacatgagccctagattcttggagt ccagaacttgaaga 1412 2672266 ALS2CL NO gtgtgagcatgcacaggttagggtgggctg 1413 3730349 -- NO tgggcctttcaaattgagtctaagtttaaaagatataaagaggtgtgggggaagggcattcctggcagaggga- agagcatatgcaaaggtgtggaggccta gaactacactgcagctttaaggggtggtgagtgatggccgggcaccgtggctcacacctataatcccagc- actttgggaggccaaggcaggaggattgct tgagctcagtagttcaagaccagcctgggcaacatagcgagaccctgtctctgcaaaatatttttaaaaa- attagctgagtgtggtgatgcacgcctgtctact aggga 1414 3755723 MED1 YES ggctcctccatagcagagaaatcttatcagaatagtcccagctcagacgatggtatccgaccacttccagaat- acagc 1415 3861643 -- NO ctggcaagcagacgggtttggaatagacattggaagaagcttttagggcatcctagacagcgttgcgatgctt- ggggcaggggcaggaaaaagccactg atggactttcagggcagagctgtaatcgagttgatgtttcagatttagtcgaagggtgtgagagggctga- gacggagaaagtggtgtggcagaagaggttg ctggtggccatgggtcggggtgcagattatgagagaactc 1416 3542787 PCNX YES tttgatcctatgtgggagcgactgaaaatagaatgagcttggttaagcacctctcctttgcc 1417 2468417 RNF144A NO tgccaccaaaggcatggctgtgggc 1418 2520238 NAB1 NO gggaggaacatttaagctgatggaagtggaagtggaagttgctgtacattggcagcaaggcctccgagttagc- ttttgaatgcagttaactggtttctcttaac tgtggaattcattgaaaagtcagactccgagtggtcgttccaggatatctt 1419 3129693 -- NO cagcctgtgtgtactcatttccttctcttgagtaccactaatttgatagttcacgtatcctctactaagaggt- agagtgagacagcttagggacatcagaagtact actttcggttcttccacatggaaacatgaggaacgaggaataagtattctttccctaacacttacagtgc- acttaagacaaagttttttttttttttggactgaatata cgtcgatggacacaggcccagatatggagaaagggcaggtttcctctaggcaagatttgcacggggaacc- tga 1420 3845840 -- NO cctggatccctgaagactgctctgagatcgatcagccagagagaaacagagagaaagctggctcagccctgaa- ggctttgagcaaaagtttcagaagga gctggaaggagacaacagcccgttctccctgagctgtggccgggagggcccaggccagcaccacgatgta- cagatggcccagggggctcgacatgag tgagggctgaagttcgtgcaaccccaaccgccacccctgaattgggcagaaccaatttttttcttagcac- ctgtctgactctgcttaccatgacaaccccaag ggccccccagaattgatatccaagtgcctttagcctatcaaagacaggagggggtgcattctcggccagg- ttagggttcacagagcatccgtatatta 1421 2621185 NBEAL2 YES ggctgtagacctggaccatgtgacagatgagcgggaacggaaggctctggagggcattatcagcaactttggg- cagactccctgtcagct 1422 2871234 -- NO tttgctgccatccatagtcttttcctaagtatcacaaaaggatatgcctgccaatctcttaaaaaatgacaat- gcagacttgtgctcaaaatgaagctacagattta gaacctcagattcaatgaactaaaaggagaatatattaaatgttaaatttgacctcagaaattccactat- actaaggatgttgcctaagacctctcaaagactga ggaccagcagaacactgcccatttcactctagaaccacacacaagtctgttgttcccaagccaatgtgaa- agctataagccttgagactcaaaagagcaca ggtgtccacaggtgacccaaacatcaaa 1423 2904825 C6orf127 YES ccaggggctcactttctccaacaaaa 1424 3133366 -- NO gtgtcagtacagccgcgtggcagagctga 1425 2577848 -- NO ggcttgcatcagcacacattgtacagccttgcaaattacacagaaattgaaaagaaggttccttgttcataag- tgcaatgaatctttgatgtccagtgatccgct gcaaacaatgaaaacaaactgtaaagcacttaagaagtttccagcactcatcaaatgcatttccttaggt- gacaaaaaatccacaaggagaatgcaaataagt ggcatttagttattagagagatacttgaaaaaaaaaaagtggaagtattttcctgcttagaatgatttct- gttcccctttgaatgtaagtggtttaagaggcattaag aacataatttattttatacttaatgttcacactacctaaatgaataaggaaagggccctacaaggaagag- ttatgtattttttggtaattgtttctgagtttagagattc aggggaagagtaatcctctatttgtgggctcttcttagcatccctaacccccaaggagatagtacatggt-

tttgacttggttatttcactcctgcattctttttcccc caaattttaagttgggtcacattgtgctggctgcaaaa 1426 3332349 -- NO ggggatgtctgcaatgtcagcactgattgcagcaccaaactcaaagacaataccactcatgccactgccaaca- tacccctggcttcctcaacaactttagaat tattatattgccctaagtgcatctagaata 1427 2416733 -- NO ggaaaagtacatgccagaagtcagctgtgcagtaacctatgagagagctactcctgtttcaccccagatcatc- acctcgattccaaag 1428 2437457 ASH1L YES aagcaccagttgagattcccagtccttctgaaaccccagctaaaccttctgaacctgaaagtaccttgcagcc- tgtgctttctctcatcccaaggga 1429 2704212 -- NO gagattgatgtggttgtcagctaaacctgctctttcagtagtggaaatt 1430 3888795 -- NO gttgtttgccttgacagtgcggctgcgcttcggcctgctcgggttaccagggaacaaggc 1431 2556326 -- NO ttgcctcagctgactttaccaaaaattccctttcccttccctgctttaagtcatttcatgtaggttagtcttc- atttattcttttgcctctctacagtagttattgctttgtgc tgtacatttgggttaaaggagttgtatatgtgtatggtgacagcataatgcctctgaagcccaggaccta- gctacttcttagctcctaacgtaatttcatccatg 1432 2878702 -- NO gtcagagtgtataaggtgaaatgccgttctgtttttggag 1433 3328538 -- NO gccatccggatgtcagctctgtggacattgactgctggttttcctggggcctcggttttcctctctggcctgg- catggactgcctcttgccttggagttgctggg atggtggggtgtgtgtgtgagtgagagtgtgttgttggggggcagtgccctggagaggacttcatagcct 1434 3496801 -- NO aggactgtgtggcggactatgcagcatagt 1435 3668198 -- NO tccacagggcagaaactattgcagagttcac 1436 3764547 4-Sep YES agcagtatttccgagacgagagtggcctgaaccgaaagaacatccaagacaacagggtgcactgctgcctgta- cttca 1437 2544277 ITSN2 YES ggagtgctagcaagtctggagcatcaaataaa 1438 2581567 -- NO agcagtttggcagccacatggattga 1439 2612556 -- NO gcctgggggaatccgtgaacgccta 1440 2894809 SYCP2L YES ggtgtattcatttccgtgtattgctgcttt 1441 3956007 -- NO gacagtcttcagaaaagggcagctgg 1442 2407214 GNL2 YES gaaacacacgtgtgattaagcagtcatcattacaaaaatttcaagaggaaatggatacagttatgaaggatcc- atacaaagttgtcatgaagcaaagcaagtt accaatgtctcttctccatgatcgaatccggcctcat 1443 2948537 KIAA1949 NO tctttctcacatcctagagacggtctttaatacgcattaaccctgtgctgccacatctggctcctgccctcat- tgcctccaatccggactcttcctctcacatca 1444 3991159 -- NO acaggtggactgcagggtcgtcttacaaaatgacaag 1445 2444356 -- NO tagaccctgacattcagctccaataatggatgtcccagtatgccctgaatccaaacaaatgcctgactgcaat- aa 1446 2480997 MSH2 YES agacaggttggagttgggtatgtggattccatacag 1447 2671526 -- NO atgttccttccaaatctcacattgaaatgtaatcttctatgttggaggtgggcctgttgggaggtgactggat- cgtgggggtagatttctcatgaatggcttatcgt catcctcttggttctgtccttgtgatagtgagttctcgtgagatcatgttgtttaaaagtgtgtggtatc- cctctgccttgctcttg 1448 2673140 -- NO aagaccacattgagccacctatctccatctgtgcttatgtactctgcttccttcttgttaggatgaacaatgg- gcgaaccttccaagttcctatttaaagttacccc aatctgtgcagaagatcctgtctcctcccacctactcaaggcattactctggca 1449 3394422 THY1 YES catgaaggtcctctacttatccgccttcactagcaaggacgagggcacctacacg 1450 2485881 -- NO ggggtgacattcagattcaatcggtctacggatgagaaa 1451 2572007 -- NO aggcttctttgacaatcgtttctgatctttagctgagtctagatggtaaaagtgaactagtgaaagggaagaa- tgagttttgttttggatggcatctcattattttttat tttctttttatttatatatttgtttttcttatttttttttctttttgattttaatacctccaccctactt- acagatattttttattttcttgacaactctgataaatg atggattggaggatcagacttgttgacatcactgatgaggcttgtcttgttgcttgtcttctctggctaa- cattccttagtaaaaatatttct atatttttttctttattttatttggtcattatttcattttgagcttttttcatttattactagataagcg- agttttgagtgtcaaatttgcacttaatttgttttt ggtactgtcataaggactgtagcatacacagcatactacaactgtaactttttacgaaaatatacatttt- ttgaagatgacttcagaaa ctgagggagagagacccacttgagactaggcagcaaacagtgaagaagaaatgagcaacatggtgtgcag- gagca aagtttcctactgtatatctctactctaagtgtacaatgccta 1452 2804366 -- NO gatacttcatctagtaattcctgcccaggttttgaaacctcatgctggaccctcctgtgcaaggctgccctgc- tcattctgctctcatctgatcctctcactgggcc agtc 1453 2369480 FAM20B NO tcggcaattgctcattctagggagggcatcatagttggtcagtcttaattcccatgccaaaggacaaacaggt- gtgacatttggatagatgaatactgggattg gctctggagcatgtgttttgagttgaaccttgcagtcctttctctacgcccgtggattttgtggaaaca 1454 2556336 -- NO agtcctgtctagtggtcagtcctaacagtgtggttaaaggggagctaaatttcaactttcaggggtcagctga- gacaaccacctagattttccaagttagttcca atttcaagtacaataatcctttgacaacatagaaaagaattatagttagcaaaattgcaattgtcacagt- caaggtcttgttggtaatagagggttggggaaaaa gttaaaacagcattaaatgaatatatttttaacataacaaaagttcccagaagacatccacttcaaattc- aagccatattcatcaatgttaaaaaccttactcttctc cctgatagtgtgaggaaaa 1455 2589618 TTN YES cctatccctgtaaagcctgtcccagaag 1456 3405368 -- NO ctggggcataaaaaagcaagtgttctcactgagggatgaatagtctactagcaactgtaagacagttgcacga- ataatgatgatacaaagaggtatccgatg aatataatgtagcaggataaacaaaatggcagtggaaaacaggagtaaaaccaaagggaaggattctgag- aagactatttataatgggaactaaaattgtca gctgaagctcagatggcggtagaggcattccagatggagtatagaaaatgaatgaagaccaaggacagga- cagaaatatctggggtgcactcactaggt gagtgtgtccagacattgaaagaggatgagcagaggaagagaacaggagaggtaagaactaaaaaggtgg- tattaggtcctggaaggtcttaaatatcaa gctaaagagttttactgccaagctacagaactttatcaaatgccatactgagaagactgatcgatttatt- aaagcaaactcctaaaggatctcttcttggaaaca attcattagtggttagtgtggaatctcagtgtggcacggaataaagtaaagtacatgggtaacggcccca- gaaaaaccagagcacagcccagcgcattacc actcatcgcctgggtgatcttg 1457 3447472 -- NO ttttaaggagggttgcagaaagtga 1458 2331932 -- NO tgccggtgcagttccttggtatactga 1459 2413973 USP24 YES tacgtcgatggagttcagcacaagcacgagaatttgggaatcttcacaatacagtggcgttacttgttttgc 1460 2972147 -- NO aagtcaggagggttcagtgaccaga 1461 3568132 -- NO ttaggtatttcgagtttgaagtgtctataagtcatctggagctgtccaggagatggttctatacatgaagatc- aggaccagtttcttgtcatca 1462 3593984 -- NO ccaggtggtctagcgctcctaacaaacaccttatgattatccttcattcaacagaggaggagactgcaggcat- gcttcagtcagtggtaagaacaggaagaa aaacccaaatcagcaacattttcttccttaatttggtataaacgtccttttcattatttcaagttactaa- tttgctaatctcaaatgttttctgaatcaggtttgctaaatg ctgtaaagaatagctatccttcatacaatactaggttttattttttttagtatgtcagcataataaggta- catgcgcattcattccaccaacctgtttagataatactca gcttgggtcatattcaaattctacacagagattctctgttttcaatacaactgcttagaaagcagaattg- cctagtgatgactgta 1463 3878647 -- NO gcagcccatcccgaagtgcttattacattagaacatttagtgcttttaaagatggtgtgtgtgtgtgtgtgtg- tgtgtgtgcgtgcgtgtgtgtgtgtgtgagaga gagagaaagcatatctaaatgttggtaccaaatcataccccattggaaagattcaattttctgaaattcc- acctaagaatttttgtatgtatatatgaaggcaattgt gaaattatagagaattagcaaagtttatttagaatttgaggggtttggagtgcagttttacagattttct- gactctcttttctttaatgtccatgcagagactaacata attgacttttagatctttatccagagagtcaatccaattcaattcaaaaatgtttattgccagtccactc- tgaaca 1464 3271123 -- NO gtgagtccctgggtcagtgagcaca 1465 3291284 TMEM26 NO gaaagtggcttatttgaggttgttggtgctgttggtattattgccatagttgttatttaattgcttgattaaa- ctcagtcaaatatccttccta 1466 3859781 DMKN NO caaggagccaccagattggatgggagcccccacactccctccttaaaacaccaccctctcatcactaatctca- gccttgcccttgaaataaaccttagctgcc 1467 2326309 -- NO ccttcacggatttggttggggtcagagaga 1468 3091040 BNIP3L NO agtgcattgtgctctttccaagttcagcagcagttctatcagtggtgccactgaaactgggtatatttatgat- ttctttcagcgttaaaaagaaacatagtgttgcc ctttttcttaaagcatcagtgaaattatggaaaattacttaaaacgtgaatacatcatcacagtagaatt- tattatgagagcatgtagtatgtatctgtagccctaac acatgggatgaacgttttactgctac 1469 3823592 HSH2D NO ggggtgcttcatgtcatagcttctcagaaagcagcagtaactgaggctgtggatctgagaacgggagctgcta- gccaagcaatgagtgaagcttttgtccgt agtggcatgttttatctgaggccagcctttgtactcctgtgtta 1470 3551323 CCNK YES ctacaccacaagtgccgcaagtacagcagtcacagccgtctcaaagctccgaaccatcccagccc 1471 3602745 RCN2 YES atggatttgttagtttggaagaatt 1472 2332284 -- NO cccggcgcgtatcgtaggcagtgtaccgtggccgtgccgtcagagtgtgcgtgtgcgtgtgtgccgtgtcgag- gctgtgtag 1473 2689891 -- NO ctagaactatattagctgctcagtgagttgggcaattggatatttttggttttatgatttcagattttataga- ccagtggaatacaggccttgtgcatatgaagatca ggtgacaagtttgc 1474 2952713 -- NO tgtttgttgtttggttatgatcttgctt 1475 3181289 TMOD1 NO cggtggagtccatgcctttgaactggatgtgttctattgatgacctgtgctctgcaggggaaaccagaaggca- aaatgctggcagcatgaaacccttttgtgg ttcagttctttatgcactaaggttttaggttgactagtggttgtagttgaaaattttataaaataccgtt- aatgtgaagtttttctttagtcacagaagttgaatctggtt attatttaaaaactagaagcccccaaaccagcagatcttactgaagatgatgttccagcagcagcgactt- agccccaggagcccagtttcaatggccttgctg tgtggtgtttcaagtgcatttaaaatgtgtgacacagaaacggcacactcttc 1476 3412443 -- NO acctttgacatctctagcacacggagcaattctagatggttgataaaagagcataaatcaatcgacacaaata- tccccttaaaccttgtctttcatgtccagtatt 1477 3886313 TOX2 YES atgagtgacggaaacccagagctcctgtcaaccagccag 1478 3976557 RBM3 NO atgggacgtttgtagaacctgagtatttttctttttaccagttttttagtttgagctcttaggtttattggag- ctagcaataattggttctggcaagtttggccagactg acttcaaaaaattaatgtgtatccagggacattttaaaaacctgtacacagtgtttattgtggttaggaa- gcaatttcccaatgtacctataagaaatgtgcatcaa gccagcctgaccaacatggtgaaaccccatctgtactaaacataaaaaaattagcctggcatggtggtgt- acgcctgtaatcccagtgacttgggaggctga ggcaggagaatcgcttgaacccgggaggcggaggttgcagtgagctaagatcgcgccactgtactccagc- ctgggcaacagcgagactccatctcaaa aaaaaaggaaatgtgtatcaagaacatgattatccagcggtattttctaattcagatcatcaaactgatt- atatagaagagttggctttaaaatgtttgcaaatgtc tttttttttttaatactggaagaaaaaatattctgttgtgtctcatacagtgcttaggatgtctttc 1479 2635686 PVRL3 NO ttccatagctgtagctggagcggtaattggagctgttcttgcccttttcatcattgctatctttgtgactgtg- ctgctgactcctcgaaaaaaaagaccatcctatct tgacaaagt 1480 2680971 -- NO agttggcttacaacctgtgctgtattga 1481 2715956 HTT YES ttgagttgtacagccgctggatcctgccgtccagctcagccaggaggaccccggccatcctgatcagtgaggt- gg 1482 2452913 -- NO ctgtgcacaggactcctcaaatattttccgtt

1483 2667796 -- NO caagagaaggtgagcatataacaggtaaataacagaagctctgattttttttttctttttatagtttgggact- attcatccagcaagagaaggacgcttaaaagta gatt 1484 3602153 C15orf39 NO aagggattctgatgagccgatgggccctggaggcagcccattaaagcatctgg 1485 3752031 CRLF3 YES taccaaaaaggcctcgcacattcagttggacag 1486 3765307 APPBP2 YES ggaaactgaacagaggctgcttcaagaagctcatgatttgcacctgtcttcactccaactagctaaaaaagct- tttggggaatttaatgtacagactgcaaaac actatggaaaccttggaagactt 1487 3956644 -- NO gtacatgcaaacgggatgggagcag 1488 2345202 -- NO tgatgcccgcgttgtcttttcagactctgttttttgcctttagcatgccttgtaatttttttttttttttttg- ataagctggatgtgacataaggggtaaaaagaactgaga taaacaggcctttagtgtggcctagaggcctatctggctaggagttaggctgtgtttactgtttgatgta- gctttggtgtcagagattaaaatttcctctcgtgtaa ctgcttttgtctcctttgttgtctttgggtttccctaataactccttcataagtaggttccgaggcttgt- agttatttaagctgtaagtccctgttattacacaggagcc ctattgatgtggtgtgtgtgtgtgtaaaagtgttctataatcttatgattagctcttagtgagcctgtgt- ctttggactgtgaccttcatgagtgctttttagc 1489 2655521 ABCF3 YES aaaggagagtcggttggaatcatctggcaagaacaa 1490 2920283 -- NO gcaggacatacgctaaaaccggagcaatacagagaagattagcatggccctcacccaaagatgacacgc 1491 3102056 -- NO agattacaaactcacatttaatgttataaatgcagaaaaaggccaaaaacacaaaaagagtggcaacgaggga- cag 1492 3161310 -- NO tgaagaccttcacgctttctctgtaagttttcattcaaaacatctttcaatttcttttttttctttttcttct- tttttgccctcattttagttagtttgagtttcttgtggctctgta gtgactgctctaatagaatatcccttacaactttgtggcagttaatttctggatgatcactgtgacttcc- atttacatgtatttgg 1493 3289083 -- NO acaggtaaattaggacggcactgcgggtactctgtgttccgcctgctcaagttctagacttctggtgtccata- gcaacccagcaga 1494 3304760 -- NO cggggaggaaagacagctctaccag 1495 3895434 C20orf194 YES tctttcctgggcacttatctaacag 1496 3406522 -- NO tggttttgtggataggggaaatctagtagatattaaatatttttatctgcaaaaagcatttggtaaggttctc- aatgggagattaatgactaaaataaagaatgagg cattaggagataaatttgcttatgagcaagagacagatactaacagtagaaggaaatactttttagattg- gaaaggagtgacatatagcacaagccaggaatc agttttgggaccta 1497 2692051 -- NO gtatcggattaagctcaaaacgggaggaggaaacaaggatgactggagtcaaggaa 1498 2835105 LOC728264 NO ggcaggggttgggacaagtgctaagtatgcaagactcaagggaagagct 1499 3935012 -- NO cttctccaggccagatttaaccacataaacacatcaaatcccagct 1500 4038282 -- NO tggctgggtgagttctaaaaatgcccaagacctccaagactaggtgagatctgaagtaatgaaatgcctccat- tcactaaaggcctgaaattgtcctgactgc ctcag 1501 2856770 -- NO atgttcaaccagatgatgggccatgattgt 1502 3579731 -- NO cccatgtgtatgctttgagccgttccttagttgagtaggtgattgaccataccagcagcactggtgccaatta- agcggtctgcttggttcacacagcctttcattc ctgttctagcatggctctgtcttaaatctgcatgcatgtatttattccttaatatattacctctcttcct- ttcttcctttttacatttcttcccattttttattgtttctctctctct cactctctcactcattctctcttgcactttgtcttcggagctcattgccatggagtggcttggctgtacg- catcaaaaagccacccgcaaacgtccatccttggc cgtgcggttccacgtctcactcattacttccttcctgcattcatagcatccttccttcctgcttgctctc- tttttattaggcatttattcctctattagtggagtcaggtg cccttatgacaagtcctagc 1503 3636549 -- NO ctactgaaagcatgtcctgtgaatgttacttgtcagtgacaaaataggtacagaaattgaaataagagtttag- aaatttttagagccgtttgatggagtagctttgt gaatctaataattgaggcttacattttgtatgtctttatttttctcataatttatttttattttataaac- atgtctgtttgcaactcattagaactttaaaaaaaaaaactagt cattcactctaggtagagtagaagtactgactatgaaggatctttaaaggtcaatagtggtcctaatacg- taaaataatttgctcatatggtgtatttaaactattg gcaactatgtaaaagggggaatgggttgaccttcatgttacaaatattaatttctcctgcataaaagtac- cctcattg 1504 3653150 -- NO tttcatgagatctacacctgggctgggcacgcctgttggttttttactgacaacgcataatttttcgaggagt- ggtaatcagaggcaaccgttctagtgacagtg attcaggcgtaaacacttggctttggcccagaggttgcactgtgtgagaccacaggtgaacactagaatg- tttacactcttccggagtctgtaggtggatgcca 1505 4011856 IL2RG NO cagggtcctgtagccctaagtggtactaactttccttcattcaacccacctgcgtctcatactcacctcaccc- cactgtggctgatttggaattttgtgcccccat gtaagcaccccttcatttggcattccccacttgagaattacccttttgccccgaacatgtttttcttctc- cctcagtctggcccttccttttcgcaggattcttcctcc ctccctctttccctcccttcctctttccatctaccctccgattgttcctgaaccgatgagaaataaagtt 1506 2351151 -- NO aaatagctgggtctcagtgtctcttt 1507 2577491 -- NO gttctccctagttttctctacaacagtggaaaacaaagcagtgctctctatgccaggacagtacatttggacg- gcgacaccttgtttgcagaatcct 1508 2693258 -- NO atctacattttcacactgacaccca 1509 3156385 -- NO agtcacacccttggggatctcattgtgtttcatgacttaattatgctgctgactctcagattgttatcttagt- ttttcagacttctttcttgaactccagacccgtggcc actatgttctcgccatgtggaatctgatgtctcataagcatttcagacttaatatactcaaaaggaactg- atattcacgccaagcctgcttctctccccttctccact cactaaatggcactactttccttctggctgg 1510 3175668 VPS13A YES cttggaggtattatagcagaagtgaatttggccgagcattctacagttattacatttttagattatcatgatg- gagcagctacattcctcttaataaatcacacaaa gaatgaacttgttc 1511 2389740 -- NO atgagtgattcattctgccctgtggacacttgggaacagaaggcgactcttgagctgggttttccaggcttat- taggcgctcagtgggttaacagaatgagctg gtccaggaagagatcagcctgtgaaagccgtggctgggatattattggagat 1512 3224499 -- NO atctcttaggtcatatgtcatcgcattacctttaaaaattgtatggtctaaatgtaaaatagttatttttcaa- catttgttttaatacccttgtaactgctttttactcaaga cagacatttcacttacactaagtgtgtgtgtgtgtgtgtgtgtgtgtagaaacttaggatataacacgta- tgtaaattacacacacatacctgtttaaatgtaagaa ttcagtgataggaacagttcatctaagaagattttaatgacagggcactcttttggccaaagcagtggaa- tttcctaagcagcaaggttggtaatagtgctggta ggatctgtatgtgtaagctgttacacaagctgaggatcaaagtgccaatttctcaaggagaaaaacttct- ccgagaaatgaaagtctctgatctgtgttgtatgc cctaa 1513 2807754 C7 NO gggccagaacacactctacaaaatgactaggataacagaaagaacgtgatctcctgattagagagggtggttt- tcctcaatggaaccaaatataaagagga cttgaacaaaaatgacagatacaaactatttctatcctgagtagtaatctcacacttcatcctatagagt- caaccaccacagataggaattccttattctttttttaat ttttttaagacagagtctcactttgttgcccaggctggagcgcagtggggtgatctcatctccctgcaac- ctccgcctcctgggttcaagcgattcttgtgcctc agcttcccaagcagctgggattacaggtgcccgccaccacgcccagctaatttttgcatttttagtagag- atggggtttcaccatgttggccacgctcgtctcc aactcctgacctcaggtaatccgcctgccttggcctcccaaagtgctgggattacagacatgaaccacca- cgcctggctggaatacttactcttgtcgggag attgaaccactaaaatgttagagcagaattcattatgctgtggtcacaggggtgtcttgtctgagaacaa- atacaattcagtcttctctttggggttttagtatgtgt caaacataggactggaagtttgcccctgttcttttttcttttgaaagaacatcagttcatgcctgaggca- tgagtgactgtgcatttgagaatagttttccctattct gtggatacagtcccagagttttcagggagtacacaggtagattagtttgaagcattgaccttttatttat- tccttatttctctttcatcaaaacaaaacagcagctgt gggaggagaaatgagagggcttaaatgaaatttaaaataagctatattatacaaatactatctctgtatt- gttctgaccctggtaa 1514 3929304 C21orf59 NO tccacacagtgagagtccagggctcagggctgctcaagaccaaggcttcccttgatgcttcacttcgggtgat- cagacatgggggacctgtttatctttagta gccggcaaaggcaatcgtaaaacatttgttgtaacttcaggattgtcactctaagaacacc 1515 3947636 TSPO YES gtacggctcctacctggtctggaaa 1516 2748234 -- NO cgaggtttatgttgtgttaggctcatgagaaggcaagaaattttattatttaaatgttttctccagtaatgta- ttggattcaagccattgagatttggggagtgtttca gtgacttatttgggcaaaacagaatatttgaaattggcattgtctcagaatctggc 1517 3630746 ITGA11 NO gactgtaaatacgaacccaatctgcacactccaggcctctagttccagaaggatccaagacaaaacagatctg- aattctgcccttttctctcacccatcccacc cctccattggctcccaagtcacacccactcccttccccatagataggcccctggggctcccgaagaatga- acccaagagcaagggcttgatggtgacagct gcaagccagggatgaagaaagactctgagatgtggagactgatggccaggcaagtgggaccaggatactg- gacgctgtcctgagatgagaggtagccg ggctctgcacccacgtgcattcacattgaccgcaactc 1518 3004500 -- NO ctcatgcttcaaaggcatattctcaagaaacaggtgtaatttgtgcagataatcacacctgggaagggatcac- agagaaggagaaaaagaaagaaatggct tattctgaggtgaatgtgtc 1519 3552925 DYNC1H1 YES tgccaccttgatgacgcagtgcaaagagggggcacagaaggaaggcctgatgctggactcgcacgaggagctc- tacaagtggttcactagccaggttat ccgcaacctccacgtcgtgttcaccatgaacccgtcctcggagggactcaaggaccgggcagctacatca- cc 1520 3649810 -- NO cagcaagaggtgcaggttgagtatttggaggtggtatatttggccagactttagccgcatcgattatgctatt- tcttgctggctgttttaaattttttttaaaaagga ggaggtgtcagatacatcatttca 1521 2782685 -- NO aaaactagggctgtccaggcttaca 1522 3166121 -- NO caaaagcctgctgctgggtagatag 1523 2524769 -- NO agtgtagtgcagcattgcctctggaactggcctgattcttgcctcataaaattcttgtgaccaataaatgaaa- ttctacacatttttatgtgtctaaaatcccaagac tagtatctgacacatggttagctctcaatatattttagctactgctattatcattattggtagtactatt- aaacattttgaaacagaaaatcacttggggctggtcacg gtggcacacgcctgtaatcctagcatgtggagaggccgaggcaggtggatcactggagctcaggagttca- agaccagcctgaccaaatggtaaaatcctg tctctaccaaaaaaatacaaaacttagatgggcgtgatggcatgcccctgtagtcccagctactcaacag- ggtggggtaaa 1524 3101675 ADHFE1 NO ttaactgaaagaattaccgctggccattgtagtgctgagagcaagagctgatctagctagggctttgtctttt- catctttgcgcataacttacctgttaccagtata ggtgggatatacatttatcttgcaggaaattccccaaagctcagagtccagttccttccataaaacaggc- tggacaaatgaccactatgttagacccccaggc tcgacttcaggggtcagtgttcctgtcccaaaccccacacagaatactctgcctctgtttcatgtagcaa- atga 1525 3633418 SIN3A YES cacctctcacttgcgtatgaagacaaacaaatactggaagatgctgctgctctgattatccaccatgtgaaga- ggcagacaggcattcagaaggaggacaa atataagataaaacaaatcatgcatcattttattccagatttgctctttgcccaaagaggtgatctctca- gatgtggaggaagaggaagaagaagagatggatg tagatgaagccacaggggcagttaagaagcacaatggtgttgggggcagtccccctaagtccaagttact- gtttagtaacacagcagctcaaaaattaaga ggaatggatgaagtatacaacctcttctatgtcaacaacaactggtatatttttatgcgactgcaccaga- ttctctgcctgaggctgctacggatttgttcccaag ccgaacggcaaattgaagaagaaaaccgagagagagaatgggaacgggaagtgctgggcataaagcgaga- caagagtgacagccctgccattcagct acgtctcaaaga 1526 3904327 -- NO ttccaaaggtcgctaaagatactgttactactattgagatattattggctacttcacgtttacatagtaaatg- tttgcagcatataacattacagactcataaaccca taattaacttataagtgttaatggacaactgtgctttgatttttgcctttagtgataagaaaacaaagta- gtgaaatgggtcactcctcaaagcatggaacattttaa ctttgcctagtaaggaaaaacaaaacaaaatatagcaattacatgtggaaccgtaacctgcaaaagtaac- acaaatattgtctcaaaaggtacaaataggttgt acctggaccttaagcagcatg 1527 2652509 FNDC3B YES gcaccaattgacaacggttcaaaaatcaccaactaccttttagagtgg 1528 2441680 -- NO aggcaagagccctttcgtgcaagtaagcaattttgctgcctcccattttttttttttttttcaatctgtttgg- gactttgagggctggggtgggaaggtagtggaatg gaatagataaacagccagtcaagagctgtggggaggttgacagaattggggtgcaggtacatgtaggata- cacagaagctttgtgtctgtggaggctgtat

gagtctgtgggtgagcagcatgtctaagtgggtggaaa 1529 2694895 -- NO atgccttggagacgagcccagaaggag 1530 3048170 C7orf44 NO tcctatcatagctggcaccgtgttcatgcctgtggtattccctgtatccctattcctgggaagcagcccagga- gggggattcccttggcctctccagggtcagg tcacctttcccttcattagtgtgatgggaccttcagaagagaagcactttctgcggccaaactg 1531 3085948 -- YES gaggccggtagtgctgaatggacatggggctggatgaaaagacttccgcctgcctctctcagccccggaatcg- ccatgagctgctatt 1532 3300246 CPEB3 NO ggcctttccttggtgtgacacttgaactagtcgattttttgaaggctataacctaacctcgactatttgttgt- tatgtgca 1533 3822344 MGC3207 NO ttggagacaccatgttagtcgtggctggtctccaactcctgacctcgggtgatccgcgccccgcggcct 1534 2345520 -- NO aagcctgtttgagagcaggactgat 1535 2549493 -- NO gctccggccgagagaagccaccattcctttc 1536 2788417 ZNF827 YES gaagagttactggaagcggcacatggtgattcacacaggtttaaaaagtcatcagtgtccgctctgtccattc- cggtgtgctcgcaaggacaatctc 1537 2544515 ADCY3 YES actatgtgaccttcatggtgggggag 1538 3329911 NDUFS3 YES ccactgtcagaccacggaatgatgtggcccacaagcagctctcagcttttggagagtatgtggctgaaatctt- gcccaa 1539 3467685 -- NO cagggagctgcatgtccaactgttctcaggggagaaagtttggccttctctaggaacagacggagagaaggca- agggatcctaagggagatggtgcaag ggcttttggggagtttggggtttatccaaaatgtagtagagaagagggttcttgaagagttttcagcagg- gatgggacatgtgggatttgtgtaaagcaggga gcaaactatggctcaagggcctgctttggctcactgcctgtttttggaaacaaagttttattggatcaca- gacacaccattagttttcttaggagctacaaaggc 1540 2535364 -- NO atcaaggaagtcgagtaaaacacttct 1541 2979944 SYNE1 YES gcagcaaataggtgaaagattgaatgaatgggcagtcttcagtgaaaagaacaaggaactctgtgagtggttg- actcaaa 1542 3210881 -- NO atggctctacagcaccggattttgcatcagaatccttcgagtttcttatcttcaccatctgtagcatttagat- tgaaaaggcttacctgggttttctttttttgtgtttt atgatctcaagctattgggagtagaccaattcgtgtggctcaatatgagagttaaagttacgtcagaagg- taatgaaagctgattttgcccttttattaactatagt attttaatcctggtatgtaaaattattactcatttgtgcctaatgcagataatgggaagcagctcactgt- ggtaaagtaggggcattaagcacaggtgcaac 1543 3984493 -- NO ccagggaaatatgggaactgtgagaggcagcaggcaagttatgggcagaggcagatacaatgagttcatgtgg- gaaattt 1544 3294206 -- NO ttttttctgcactcccattgcttta 1545 2389550 -- NO atgtattggtggacagcatctaggaagaga 1546 2593736 -- NO gctgtaacactttactatgtctatgcaaatacacatttaaacaatataggaagatttcaataaccaaactaac- tgtacaaaaaataaacaaattaactttattacatt gctacttcaacttcagtccttacattgatttgttttttaaaaaataccagtttgaaacacattactgaaa- gtgagtgtacacaataaatagaaaatagggatgcata gtgctggagacattcaaccaacttatcttcatctgttgcctactgttg 1547 3315642 ATHL1 YES gaatgcagacgggtcaggcgctgtgaacttcct 1548 2638195 -- NO gtcaacgaggggaatccactctgcc 1549 3973655 -- NO cagtttggcaaagagcatgccactgttcctgctgtctatcaaag 1550 2409486 -- NO tctgaaatccgacatcccagtgtccattctggggcacagcttcccctcctttcaagtctctctcttcctccct- ctccacaacacagaggcctttagctccccagc ccttactgttcagtgcgtccacccctccttgtctagaccctgaagtatattacatcagctactctcttgt- gagctcctccagtactctgccccttgtccttctattgcc ctagtctagg 1551 2635963 PHLDB2 YES cctgcctgtccggaaggaagactttgatttgcggagccatgtagagactgctggccacaatattgacacctgt- taccatgtatcaatcacagagaagacctgc cgaggattcctcatcaaaatgggtgggaaaattaaaacgtggaaaaaacgttggtttgtttttgatcgga- acaagcgaacattctc 1552 3730508 TANC2 YES tccacaatgttgctgccttgctctgccgctcacctcagctgacagcctatcgggagcagcttctcgggaacct- cacctgcagagcatgctgagccttcgttc ctgtgttca 1553 2512118 -- NO ggcatatgtttggtatctctggtccttagttcctgaacaattctgggctaatgctgtagtca 1554 3181032 -- NO tgcttctaacaaatccgccctgtcacatgcatatgctttctcaacattcactgtcaaaaatgccctaccagga- cacaacatagtgacaataacacattcaatttaa ggataatggttgagagggaaccagctaagaacttacaata 1555 2401404 ASAP3 NO aggcctctggatggcagaaggaaag 1556 2496802 MAP4K4 YES tgatctttggtcttgtggcattacagccattgagatggca 1557 3048180 -- NO tcagatttactttcccggagtagtcacaggactgggcagtga 1558 3436406 -- NO ctctgtgccttatcaggagagggtgactctgtgccgactttacaaggctatgggaaggacac 1559 3840203 LOC400713 YES gctgtcgtagagtggcaatcatcagtggc 1560 2633650 NIT2 YES ctggctgaaatacgccagcaaatccccgtttttagacagaagcgatcagacctctatg 1561 2835873 -- NO tgatcaaatagtgccgtctgcctggagtacagcatgggggaagaggtttggctgtgttttgatgtagtcactg- cccatagtgttgtagttgcttcattttgatgtgt catacagctaaagatgctccctttaggtcatttttgttgccgctgcctctgcggcttgttactactgtt 1562 2849540 -- NO agaagacaagaggaagccgttctgctggcatttcgtcgggatgaagacaacacagcca 1563 2986834 -- NO ctggccgtgtttcctgtgagttttgagg 1564 3222790 -- NO tgctgttctgcttctcccattcttgcatagagtaatggagttagtgaaaatgggctttcttttacaacacaaa- gtgttgctcttctttctcctagggagaaagtagta agctctgtgggtgtaggaggaggaaaatagcaggagcttagccaaggagggtgctgcagcacatgtgggt- cttcatagtccggaagggtgagtgacac 1565 3317133 -- NO ccaaaaggactgtcgtggcagagcagccatggccaagtggactcagggttcattttcggaacccctttaagct- tatagaaagtccccatcatcacccagctc ggccccggggcaccgagtccgtctggtgtggggcgtcctttcgacagagcctcctccacaaacccagact- ctggcttccaccagggccccggacacctg cttcctcagggcagacagagaggggtgacacactgcaccctgtggctgggaaaaggggcctgggactgtg- cccgtctgggacggagcagagccacca tcccatgcaggcactatcaccgcaggcaaa 1566 3600340 -- NO agggccactcaaccatgcgctctgggaggagtgggctgagatggggctgcttggtcagccctgactgtgtttt- gatctttgggcgtcacc 1567 3929187 -- NO ctggccaccagggaacagttacgtaaattatttgatgtgtctttttaacaagatattaggaagtgctcggcat- tgttaggattttttttggccacgtggaaaaacac acatgatataaagcaaaggaaaataaggcagtctgcaaatggatctgcttagaactgccattacgtaa 1568 3989061 -- NO cttgctctgtcataccttgtggaaatgtaaaagatcaatgacagctagcctttcacacaattatttatgcctc- ggccctctaattgacacagttacccctagcact catcgttgtgatcacctgcagccaagacgctgattttctgctcctatagcctggcaaccttgtggtacat- gggactacgtccttta 1569 2735839 MGC48628 NO tatacatatgtctgcctctaataaa 1570 3660480 -- NO tgagaccgcaattccagcacgcattggcaggacct 1571 2655657 -- NO tgggaggaggacgtctttgggattccttctcttcatgagctgc 1572 2848543 -- NO agcataaagaaagttggcctgggttttcgtgactcggcagggtccactcagtttaaaatgc 1573 3397172 -- NO ctgccgtgggcccattgaccagagcgacctgctgtctgatgcc 1574 3790842 -- NO atgtggcgaatgggtagaagaatgt 1575 2824108 -- NO ttttctgattcactaccactgctggtgttacagcgtgaacgtgacctgaagacaa 1576 3361136 -- NO agaagcaggtataagccaaatgttgagagttagagaatgccagcctgcagttgtcatcacccaggcttagtac- c 1577 3971846 -- NO atgttcactcaggctccttggtgtg 1578 3294447 ANXA7 YES gtgagttttccggatatgtagaaagtgg 1579 3850170 S1PR2 NO gttgcactatttggggcacagaataatcaccaaaagtgagaaaaacgagtttgggtggctggggaggactttg- ggactcttgatgcaaggcgcaacttgag aaaattctgggtgtgatatttgcacagacaccctcctttcaaaaacagccaccccccaagctattctcag- ctccacacctgcagccccagctaaggtaccag gtctcctgagcaaggcagagagaagccttgagccttctctgtgtcttctttcaagaaccccgctgtgtct- tctttcaagattttttttttgagacagtttcaagattttt gttttgtttttgagatggagtctcactgtgtcacccaggctgaggtggcagtggttcaatctccgttcac- tgccacctccacctcccgggttcaagcgattctcct gcttcagcctctcgagtagctgggactacaggcacctgccaccatgtctggctaatttttgtatttttag- tagagacagggtttcactacgttggccaggctggt ctcaaactcctgacctcaagtgatccgcccgcctcggcctccccaattgctgggattacaggcgtgagcc- actgtgcccggccttcttctttcaagttatatag aatggagcatgggggtggcagtggctagggacatttcctggggacactctcccctaaccccccagaagga- cttcacaaaaacctgtggataatggaaggg atgttacggtacaaacgtatatttatgtgtgtgtgtgtgtatgtgtgtgcgcgcgcgcgtgtgcacatag- gcgtgatgtctgtgaccctc 1580 3918219 -- NO tgcggattcgtctgctccacgcagggtgctctgacgtactctgtgtggcctggagctcagaaacctgtgctgg- actcagtg 1581 2370552 -- NO gttggggtgaactgaacctgtccattt 1582 3476124 -- NO gagcgggatcgaggcgtttttaataattcgagttgggaagacccggatggttcatcaaaatgatggtgttgag- cacccgggaggcagacattgggtatttgtt cacaattttgcacctgtaagaaaatgttcctttataactttcaaggattgccgtgagcgtctttggggcc- ttttcattcatgtacaagtttcattcattactattcaactt ggtagacttggtgaaaaatgtaaaagcattctgtatttggatcagtcttgggaactaaatttgtcgtgaa- ttggggcctgtcacagattgcctccagtgtgcatcc tccacgcagaccctccttgctcagtctccctctggcgcccatggggaagccgtgctgtggttggcagtgc- ggccatctgggctgccgcaacgtggcaggg caccgtccagcaagactgccccttagtgcagggctaagcaaggaaaagaagaagcccaaaaaggcgggtt- ctttttgatacttgtaattcaggcgtcctcc agagtg 1583 3929424 C21orf66 NO ctgttgctgattttggtgacacatctctgttgatatcagtaaatatcaattgataagtaaaaaaatatgcaag- tcttaacttggatgtatttcatcttgcatgtgctcac ctccctcccctctcacccagtcgtttgggttgtttgcctccccttactgtcatatcttcatagtgtggaa- ctaaaacgtagaaatgagggaagtatagtggacag atgtttcccccaccccttcttttacctaggcaagagattaggggagtcttttttgattaaagagagtagg- tccaaaataaagaccctgaaacactaaaatctggg gatccccaacaaaagaactggctcagtacctagtgatccgacggagacacctctgttagacagctcctgc- ccacacacacagcttccagtcttgctatctat atgaacaggcagttaacgatgatcataaggaccaacctgagcagcagaaccaaagggactgaggaaacag- acagtgctggtacaagtatgcaagttttct gtaaacagattactttcaaacagttgggagccccagggagataatagaaggtatcctactcaacaggagt- atatagaatgctgtagaagaggaatattgtaa gaacaagaactatctcttgaaaactaaaaatatgataactgaaatataaatttaaataggattggaagct- aaagctaggaaattaccctagaatgttttagagaa atggaaaatacgaagaccaaaaaaataaaataaaactatgctgtgaaagagaaagattagcatttgagaa- ggcggaagttggtcctgctcagatgcggtttt cagatgcc 1584 2418445 -- NO aggtttcaacccaactggacctgcttg 1585 2977983 EPM2A YES aattctaccaaatatctggctgggtag 1586 3074397 CNOT4 YES ttcatccaatcacagtgcacggtccccttttgaaggggcagtaacagagtcacagtcgttattctcagacaat- tttcgccatcccaaccctatcccaagtgggc ttcctcctttccccagctccccacagacatccagtgactggcctacagcaccagaa 1587 3320669 USP47 NO cggtggagcctcatgatctcttatcttttgaggctgaggcaggtcacatgcaacaaattgtgaccctgctccc- cacaagtcatgcaaaggttttgaagagctttt accgtggggcagatgaacttgtgtcaaccatgcacaccctgtgagaaccaagtacctgtgtttctaaggc- gggcactcaaggtgaggggtgcattctggcc

aaagaaacaaaagctgtggtttcaggaccatgccgtgtgtagctgatctgtacgggacgtgtatgtaagg- aagagcaatcatgatagataagaacagtgtgt gaagcagccttcacactagagtgtttggtcatctcttataatgtaagggaaggtactttaaaattctggg- aagatgcgatgaactcatgtcccagtcagaaaata atccaatgaaataagcattggttgccaggccacagttaggaattgta 1588 3562057 -- NO gagcaaaaatattgtcaggtttcttgctgtggttctggatgttcagtagcaggctcatttg 1589 3924690 DIP2A YES gggcctcgtggagcattcgtactttgagcgtccacaggtggcttctgtgaga 1590 3029146 -- NO agtcaactcggggagtcaaattaggaaaggcttcgaaggatgggcaggacgtaagaatccagagaggagaggg- atgtttggagaacagaaagtggaag gttcctgtaggaaaatgatagagctatacttggagaggcaagcggggc 1591 2480430 -- NO tcttcactgaaggtgccagcctatgggtggactcgtgatctagacctaaagggttagtgtgagttcctagagg- aaaagaaagccatgaggcagattgtggaa ggctttgaaggccaggtggagggccttgaactttattccatagacaatggggagctattga 1592 2923442 -- NO ctgggaagaacttcaggctgttgttcagggcatggatatcaccactgtcca 1593 3393487 FXYD6 YES cctctggaacctgaggcggctgcttgaacctttggatgcaaatgtcgatgcttaa 1594 3879288 -- NO gctttcaagaatacggccatgtctgcattgttggcttacacgcagacacacgctcgggtttttcatttggcag- ggtg 1595 2889490 AGXT2L2 NO catctcatccaaatacacgctattgagaaggcgagcctgacctccctcttacagataaagtcagctttcagag- gctcagggtgggggggcctgcccgaggc cataatgctacccaccccctcctcctaaccactggtctgttggaataaccca 1596 2915334 DOPEY1 YES agattggttgagagtctccgtttgccacaggtgccaactctccattctcaagtgttcctgtttttcagagtgt- tacttttaagaatgtctccccaacatcttacctcac tctggcctaccatgattacagaactt 1597 3186622 -- NO ctcatattaggatgtggacctgtccaaatcttcagggagtcctccctccccaggccaggcaatttctccagca- ccaaggtaaccactgttttgttctctattgcta tggattggttttgcttatttgtaaatttatttgtagacttggtccctatcactacgaattggttttgctt- atttgtaaacttcatataattagaaatcatgaggcattttcat aagtgtgttttcaacttctataaagagaaacacaatgtaccttcttttttgtgtcctaaaccttcttttt- ctcagtccccttccctgtacatgcacttttcaaagtgatta gaggtacagagaactcttcctctaatctaataaacaaaatgatacaaactcaataataggtggaaatgcc- cctcaggttcaatgctagagagaaactgcagg gaatggtggggactatggcaaactatggaaa 1598 3720992 -- NO catttctatggttattcgtggaatgactctttgaccacgcggagaaggcaaaacttcagccatttgtgttttt- ttccccttggccttcccccctttcccaggaagtcc gacttgttca 1599 3916840 -- NO tggcaatttcaacagttcgtcactgcacgctgcctcttaaagg 1600 3959370 -- NO catgggcttctcagatccaggtgatgccca 1601 2571999 SLC35F5 YES tggtttcactcagcgcaggcgaatggctcttgggattgttattatctgcttgttgatgtgatatgggttgctt- cctctgaacttacttcg 1602 3757901 -- NO tatttccttattacatgttccagacaggagtgctagccca 1603 4002896 -- NO ctttcatggagcaccgctgctcacgacctgttacagtctagaaaaatggaaaaactgaaaatgggtatctatg- ccacctaa 1604 4013965 -- NO aaaatctactgtggagggagtgcaaa 1605 2327098 -- NO atacttgagagtaaatgaactgctcttgttactttactatgtcaattacaaagcttaaaattcacacaagcca- cacgacatatttaagaatgcatgtgagggcca ggtgc 1606 2381607 -- NO gacatcagagtggaacttgggcgatgctgccaacatga 1607 2995272 C7orf41 NO cactcccgcttcagtggggtttctatggagttgtcttggtagcctttgccattttgaatttagagtccatttt- gtggctgactattctcttaagtttatgttggagaatta acattcgctgactcgaatgtagagaactctgaatgtattaaggataggttttgagtcctcacaggtgacc- ttactgagggaaagcatggcagagaagaaatgc agtctgcactttttatgtactttttaagtgtccgtaagtgaaaggttttgcttataaagcatgaatttta- atatctagtcattaaactgcacaagtgcaaatacaaggg caggaaaggataatcacttagctttggactaagagggtaagagaggcccagaagcctttaagtgttttgc- cattactgagttacctgggtatgtagcgactgg ttc 1608 3261789 SUFU YES gctccaacctgagtggtgtcagtgccaagtgtgcctgggatgacctgagccggccccccgaggatgacgagga- cagccggagcatctgcatcggcaca cagcc 1609 3934119 SIK1 NO tgtgcgcgtgcattgattactatccatttctttagtcaacgctctccacttcctgatttctgctttaaggaaa- actgtgaactttctgcttcatgtatcagttttaaagca gcccaggcaaagatcatctacagattctaggaattctctcccctgaaatcaaaacctggaagactttttt- ttcttattttagttgagaagtttcataaactgctcaag gattagttttccaggactctgcggaggaacggcaggaagaacctcagagagggcagaggtgacttcaaag- tgctggggactccgtcctgagggtcacttg gccctgagcccctgcgtgcccttgcggaagcccagaagcttcttcctgctgcacctcccgtttccgctgc- tgctgacgtttatgcatttcatgatggggtccaa caagaacacctgacttgggtgaagttgtgcaatattggaggctgactgtagggctgggcagctgggagac- aggctcatggctcatggctcatggctcagg gcggtgcctgccctgggccgggacccccctccccaccccccacctaggctttttgggttttgttcaagga- aggtaaagtgagaggtttaggtcagtgttttta agtttttgttttttttttaaagcaaatcctgtatatgtatctacatgggagacaggtagacactacttat- ttgttacattttgtactatacgtttgtgttccaggtttcagct tccctcgctcctgttgttaagaagcgtccctgtcagcacaggtgtgcattgaggaaggggccccagggcc- ttcgctccctcagcactggggtggaggcgg caggaaggggcggcccttacctggcaggtctgggcgcacctttagcaggtggactccgtggggctccacc- agccagaagcctctggaaggcaacgaag gcaatgctgctccctgagtccagtccccgcccccaaacccagcccaggtgccttcagctacttcggcttc- ttaaaccctgcagtgtt 1610 2748304 -- NO actcaaggtctgtccatgctggtgacttagagtagtgggatttaaaccagaggatgcacacttggaggcactt- gaagatgtttcaagggacatgcaggcattg aatatttaaaggaaattaattgccgattcttagatcttgagtgttaatcagttctaacactgaccgtcct- gagaaaatgcctatggcccaggtgacctgctggtttt cctttcacaccttctctttcatgattaccattctttaaagggaagacatacctttcacctaccccttatc- agagtgccaagtagggggataattaaaatactgctgg ggctgctgggaaagtgagtgactcta 1611 2358329 TARS2 YES ctccagcacccatgtcctgggggcagcagctgaacaattcctaggtgctgttctctgca 1612 2636804 -- NO tcttatcacaacactgcggcgggaaaatcaggaaatgggttcacctttcagcagtcaccacagtaaacttcat- tgagaacatacatgcccagatatctcttctg tgcacatgtatatgttaacagctagccattcagccaacaggta 1613 2907584 KLHDC3 NO cagggaagtcactaatgggagagtgggaggtatttgaaaagggggtttcgtgggtagtttttgtcctactttc- atctctcttttgatcccgacag 1614 3185561 -- NO gcgagtcgactcacctacctcttttcaagccggcctagccccttcccggaacctcggctcccccccaacgaaa- ctactgctaagccaactggactacacttcc 1615 3752751 -- NO atgggttcaagacctgtttatgtgcgagaacaacaggctttggtgctggtgactcaccaagatgggaaataca- ggaaaagaagcagggatgtggtagcag agtgt 1616 2366872 -- NO ttcccatccctgctctagcagcctg 1617 2389086 -- NO tgagagaggtttctattgttcactttagaaaaatgtaggtcaatgtaatgggtgatatctgttcttaattatt- ctaagaattaaatcctgtatgttatcagtcacctatta tatggcacaccctcagggg 1618 2523976 -- NO aggcaaggggtaaagtccaggatgaggc 1619 3394423 THY1 YES gcagttcacccatccagtacgagttcagcctgacccgtgagacaaagaagcacgtgctctttggcactgtggg- ggtgcctgagcacacataccgctcccg aaccaacttcaccagcaaataca 1620 3510096 POSTN YES agggagaaacggtgcgattcacatattccgcgagatcatcaagccagcagagaaatccctccatgaaaagtt 1621 2974447 -- NO atggattacgggcttttatgtgggcagcaacttgtgcctcag 1622 3000375 -- NO gtcacttttgtggcctcttggctgtaccttccctgggacaggacacggtcctttct 1623 3498077 -- NO gcagttatgtatacacagggcaatcatcagaccataatcattactgttcgaggccagaacagagacgactagc- tctctgtgtgcctttcccaagtctcaccgtg atggactgtcctctc 1624 3670758 -- NO gtcttcagagctagccggctgtgtcttctccccgtttctttcactggtgaataacctttcgtttgaaccagcc- ttgattgttctctccatgttccactgtggctcccca tggacactgctaggtggaatctctgagaaaacaggcacttcgcagtcggcgcatctttctctgccagctt- agggattgccgtcaaggtggaggaagggtatt ttggccatgttcggagtcgttgttttta 1625 3418194 -- NO cagttagctgtagagatgtgatttagcaaagttggttataaagtgggtttttgtaaattgatttccttattac- tgttctttgtagaattgaagatgtattctctcccagcaa aatagttcacctgcagatcattgaaaagtttggctgaagaaaggggttattttggtgtgggggtaggagg- cttctgtgggctgggcatggtggcttacatttgt aatcccagcactttgggaggctgaggcaggaggatcacttgaggccgggagttcaagacttgcctgacca- acataatgaatctcccatctctacaaaaaga atcagccaggcgtggtggcgcacacctgtagtcccagccactcaggatgctgaggcgggatggtctcttg- aacttgggagattgaggctgcagtggagca gtactcgtaccc 1626 3687863 ZNF764 YES gaggtggcgaaatgtcagacacaaacggac 1627 2438168 -- NO gggaatatagagaggctgctgagag 1628 3059966 KIAA1324L YES ggctctctgtaccaacaatataacagactttacagtaaaagaaatagtggcagggtcagatgattacacaaat- ttggtaggggcatttgtatgccagtcaacaa ttattccttctgaaagtaagggtttccgagcagccttatcatcacaatc 1629 3281916 -- NO aaaaagtaaggtggatatgtgcagtggct 1630 2838994 -- NO gtagaaaggggaatgtgtactgctagaggttacgggctttga 1631 2724513 UBE2K NO gtgtaccaagactagcaagagtttgcttcaggattttgttgaataattaagataatattttgagtgtgtcagg- gccattcaaattgttggtgttgcatcacagctac cttaactgatttttaacatggatcctctgtgcctgtgaatttacttgcatgcttgtacttgacttcttag- gatgggtagctgaaaagaccaccattttaagcatttgaga attcttaaatatgaaatttattcagaattgaagatggtgacctattcagagcctttttgtccttgtcaac- agactgggacagtgtctgattcccccttcacccccccc acccccgccttgccacacacagctaatattctaatggtaaatttctctgtatcaggtggggaaatgtgct- gaaggacagtatgtatcccttgcttcatttttaggtc gtaggtttggaatgtcttgtcccagttcttcaaacactcttaaattttttcttaagtaatgtaaaaatgg- aactgccaattttatttctcttgcaaaaatagtaaatacttg atgttacattattcccaggtttaatgaaagaacccaacttagtttttcagtgaatttgacacctattttt- tagtgatgaaatttttctttgagaactggcaaggatgcag tcagctgtttgcagtttttagcctga 1632 2415597 -- NO ccctgttaatcttgtggtcaccatacactcttgggttagctgtcaaattagggtttctccaccctgcttttgt- ataatgaagtttctaatcctaaatgcaggatgccc cattctgagcctgtttgtatttaacagaaaatagggattttcgtcccatttttatcttaccaattcactc- cccaactgtgccagaatgcccagaggtaatagcctttt ggaaggagctttcccatgctacattccagcagggtaaaacaatctgaaaatgttcttgccccttttatca- ctgagttctccatatcccaggctattttataaataga atttttccctacagaaaatatgtaaagccattgcgaagagaaaacttttctacacatagaaaacatgata- atttctcattagttttggaacaatacaggtctactcta agttgtttcttattctggagtacaaaatttgcattttataatgtaaattgggacactgtatactagcttt- ctc 1633 2818227 -- NO cactatgtcaactgggtgtctttgctaagtttggcatcaatatggtgacctctcgggagcaggggaccactag- gttacataaggaggggtgaactggcccag attggaaatggagcaggtcaaaactcccatgctaaccagtagtgagatggagcct 1634 3412324 IRAK4 NO atatacacctatctcaaccatttttttaactgatttttttcctaaatattcttctttacctttaacaaggcat- aggctgttgcaggacagtggttattaaagcatgggttg aacttccaaaatata 1635 3598210 ANKDD1A YES gtcggggccatatggctgtgctgcagcgacttgtggacatcgggctggacct 1636 3728164 -- NO cttgctaacgctcgccagagaaatattccgtggaggtgttaaaacaagactagtggaaagaaatggtaactta- aaaagaaagaaaatccatggcagtgaag aacagatttcatattagtactgtcataatattctctaatgtatcatataaataaaaatctgtttagacca- gaattttaataagtcaccaaaggaaggttttgaatccta

cagtttatgtatccccctttgcgatgtaaatgttcacatctcaagtgaagtagagtggggagacgcttcg- gagactagaggctgttaattagtgaggtatattttg atcagggcaagaagactggttcattctatatcttcgtatttctctggatgattatttcattttgtaaaat- atgtaagagttcccccccagccccttatctttttaaaaatt aaaatggtcatgctcttctaaaaagatgacttaatttgaaggctttggagacatgaggatgatggggatc- catcactccctgttctttgctccctttggactggag tgttggctgtctggaagagttttgcttgagctcgtgggttattttcttctatgtggaggaaccaagagac- tctttagcatctttcagcaagagcgaggtctgggtg tactcaccatctgtcttaattatccttgtgtataagaaaacattcccatcttttcccaattgccatttcc- ttccttaacttttagaggccagaacctcatctgttgatgca gggagatctcacttctttaacctatttctagttgccttcagtcacagcggggtggccaggggcgagtcac- ttaagcctccccaaggctcagtttcctcctttgta aaagagggagaattatagtactcactgcctgcagttagttgtttggaggataaatgcaaaattcttcact- gggagtctggcataaaacagcactccgcaaatgt ctgttgatcttattattatagaattattatttttattattattatttttaagacggagcctcact 1637 2779706 -- NO acctggtaaagtgagaagagtgatcaggagaagataatttgcatagtatatatagatttctattccatttata- taaaacccttgaatggtaccttagtagaaacaat ataaaataaagctaatatgggttagatgataatgtggttaagtggatttttttttcctgtctgaacaaaa- gaactgacaatttaatcaatagacccctgtcagtctgg agagatgcttctagtggtcagcacggcactctggtctttgtg 1638 3394582 -- NO aacagctcaacatgtgtcgggatgtccagggaa 1639 2429120 TRIM33 YES catattttgaaagcacggtgtgatcctgtccctgctgctaatggagcaatacgtttccattgtgatcccacct- t 1640 3428756 -- NO cagctaaggtaaatctgcttggtccaaacaaaacaaaacaaaacaaaacaccagactgcaacaataacaggaa- aagatcctcttcagtgatttatgttgttct cttactttcataactagtttgaatgcaaggctggtaaagggatacacagagaatcattattttaaataac- aaaagccattcaaaactctctctacctgtcaaggat gttttatgctcccattcttatttgtttggcagtaaacataccttgcccacagtcgccagcatcaaaccca- caggacaagacattgcatgcttggtcacagaactta tcagcgagccaggaattcgcacatc 1641 3595186 -- NO ttgtttaggcaaagcacgttatggctttttcttgcctagtttaggtctgtgcttaatgactactggaatagca- gcaaacataacatcctgataacatttgggaggaa aagccatatttgaaaattggtgaaatgcaataatctttaaaccaggaatcatcagtttgctaataaaagg- tatatggctccaagttacgtattttgtcagggtcctc tggcattttcactagtcattttgctagtgtgtacaatgattcctatcttgctgtaaaacttggtgatttt- tttatattgttgaactaggtgacatgaatattgagtcagatc acataatcttagagtaacacataagtgattatgtagcgttgtgggtggaaacaattctggataaaaagtg- catgacagttcagaactactgtgcaggcagcctg tctgaaatcaggtttaaaaattggccctgtctccagctgactcgttttgtc 1642 3959259 -- NO ctcaagcacagtcatgattggttttgtattttcttctccaggctacataataattttttgacctggttttctt- gatgccttataattctgaatgctggacttgtctctttatta cctgccagttagc 1643 2604457 -- NO acagcaggaatctgtcagtgtccctga 1644 2843218 PRR7 NO ggcgcgcgcacgacttgagacctgccacgggcagcccccggccgcgggtccccgagtgacgctggcggcacct- gagagtgtggcgcgggcccggg gccacgcagcggagcccagtgtccagtgaagcgtctgaggacccgccgcc 1645 3039818 -- NO gctgacctattgctgaggactatgagaaaaaagttattacagaatgagtcatatggaaaacacttgcaaac 1646 3483658 -- NO gcagacaatccccatcagcttaaggttcccgtcaccagggtttcccttcatcgaaactttgccacagtca 1647 3605805 SCAND2 NO tgtagtattcactactccagacctttttcaagttgaattttttttctttttccctatgtctgttcttacgtat- tttttttaaacttttatttcagtagtgtttggggaacaagtag tgtttggttgcatggaaaagttcttcagtggtgtttctgagttttggtgcacccatcacccaagggtagt- cttttttatccatcaagtctgtacccaatgtgt 1648 3659197 -- NO agagagcctagcctgaatatgccacagccgcacagagtttctcct 1649 3775146 -- NO cagttaagtgcagctcggtgagtcccggcagttccttcccggcactggctcgtccctgggttctcaaggttcc- atgcggccacagcgtccgtccacctgtcc acgcgagccacatgctgaaatggaggtggataaaattcatcaggcagctgctgtaacacggaaatgtgca- gatgccagagtagcttcgtc 1650 2534837 -- NO tgtgcacgcatgcagcactgcgataacggggcagggggagttaggtgattgcttaaagcacaagtgtgtaggg- aagaaacaaaggcaggaggggccat taaggagcctgtagagtgtttgggtcgggggctcacatttgtacagagtgagctga 1651 2705269 -- NO aaagctacaagcatggccgcctgtggtatcgaggtgttgcaaacaatatctgtgttgcgcttcctgttttaac- ctacctcgttttgtttgtttttgtttcactgttcatc acagcagtgttatctccaggagacatatagagagctcaaccggcaatctcaggtgcatttaacattttta- aaacgaaacagtagttgaccaatttttcttcttaa aaaattggaagtggggggaatccaatgacaaaaactaatgtggcttgtttctggagaaaataattactgt- aaatggaacaacaacaacaaaaaaaactacga tcttactgactttgcctaaatacacaagcagctgatgtactattaatgagaacgaaatacacattaggaa- aatggagccatttcaatctagtggtttgggcaaga tggggaagagaaggggaaacattctagtttctggattacattattatgcccctcctgaaaaggtggttgt- catttgcatttatttaaagcaggtaatatgcaggaa tgtaactgaggattatcttcaggcaatcagcaagatatcctcctcatggtccctttagctctcaaaagca- atgaaatcctcctgttctcatttttactgctgtggttgt gctgctgaacaatactatcttctcaaattccatgccacaaattcagcaataactttttggattgaattta- acaactactgtaattggatgctgatgtggacaaaatat attgatttcgatttcactcccgaatgtgattgccaccagctc 1652 3479382 GOLGA3 YES tcagcaaacagcccgtgggaaaccaag 1653 2320890 -- NO gtttcatgagacagcgatctgcctaaccattcactcctcctagaagcaaaagctaccgtgatcattgaggcac- agccggtcttcatatatcctcaaaggaggg ggattagcttccacatcccttctctattcctggaggtgccagtagtgggagagtcatggcagaagttacc- agaggcaagtggggcagaggcaagtagggta tatgtttggatcagtggatcagtgtcctttattgtgcagaaaaagctaaaattacagattcttctgaagg- gatacatagcagccgtttcaccaatgtccctcagtc catttgtccaggtccaga 1654 2824597 -- NO tgtaggtgctgctttaatgcttggactgatgttattgttgtgggagtggattagttattgtgagcatgggttg- gttataaaagcaaggtcaaggctggg 1655 3916352 -- NO taatgggcctgagtgtcaccaagag 1656 2900984 HLA-F YES ggaatgaatggctgcgacatggggcc 1657 3003162 GBAS NO ccctatgccgatgttgtcctggattaccttttttgtcctgtcttatcacttcgtctcctgtctcgggtttctg- gctgtctgttcctatttctatttgatgttgtgctctcactt cacacccagcatgtagaatcaccttgctcttccaacttccctgtctgtgccactcaccttgttttactca- gcccgttccttagttctctgtggtgaatctgtcaccta agctgtgcattcttcatcggacatgtattttggttctcttgtttccttctccatctctctctccaagcct- ctcgagccccattcccaagtagcttttttttctgactaccttt ctgggctccaagctatacctgtgtctccttcctgccctgcaatacattaccccaaagtttgtcagattga- tctgcttgagttctgttttcttttttcatcacgttttttcttt tctctgaaactttcagcagctccctgtttgcagaacataaagacttaactcctgcctggtttttaggggt- cccaataatgggattctgcccaacccatccagttct gggtacaagtactgcctgccttacaatctccattcaggtaaggccagggctcctaagagcaggtttgggg- tccccagcaaagaggagtggctacaaatcca tgcgtgactttgtgttggtgaaaaacctgggccccgttgccaggcccctttctggaccccacctgaatca- tgtgtactgggcttcctcctgggcactgcctcca atgcagggttgtctattcctgctcatgtcatgcgacgaaaaggaaatgttggacatacatttccctagca- gaatccctctttccctgtcctcgattttcattgatcc catgttatttctgaacattcatgagtcacgcatcagatacatttaatatcagatcctaatttaaaaagta- aatgctactcttccaaaagtacacatgatgtggtcact atactgggtcataaagatgtatgggttttcagttagttagacttagaccgt 1658 3743421 -- NO ggaacaggagaagccccaattttcagaagagaggggagttgattgagaagtgtaagattgttacttgagaata- atcttgagggtatgaaggtagggtaagg gagaatggtgataaactc 1659 2949593 DOM3Z YES ctggcggcccagtcaccgtgtctgtacaccaagatgcaccttacgccttcctgccc 1660 3824798 MAST3 YES acggcagaagatggtccctcgcgtctctcccatcttccggctatggaaccaacacac 1661 3933890 -- NO tctccgtaaccctataacagtccgata 1662 3340811 -- NO catttatttatgatcaaccagagagactaaacagtggactcatgggtttggactctattgcaattcaa 1663 3888249 DDX27 YES gatgaagaactcaccaacacaagcaagaaggccct 1664 3932432 -- NO atagggaatgtgctttgagctgttt 1665 3941419 -- NO caggaaaagagttggcctggacctgca 1666 3976987 CCDC120 NO gttgactgcgtgtccattgttgttatagttggttgaatctgtcccattaattctccttcc 1667 2892314 -- NO acatggccagtactgtttcaggggaatattgggtggcgctgg 1668 3379157 -- NO gggccagagaactttacaatgattatgaagatcaaagggcattagaatcaagctataaagagccactgtttga- tgttgggatgtgaggatgctgcaggtggat gtctgcacgttgatggtgagaacatggtcaccctggccctgctgggtctttgctaaagagactgtgctct- gttcttggggccgttttcatcacctgatta 1669 3830022 -- NO aggacggtcggcgtgcagagttcctggagtgctggggggcctgagatggttgtatgacgtctggaggattcag- gagggtgtatggggtctcaaggacac 1670 3904149 CPNE1 YES ccttggttcagctgtccatttcctgtgaccatctcattgacaaggacatcggctccaagtctgacccactctg- cgtccattttcaggatgtggg 1671 2408020 -- NO tgaaccatccattgcctaaaactccagcaaccctaaaaggacccaatcaaccagaagaaaaaatactaatacc- tcatatcatacagcaacctaacatttcaaa gtgctttcacatgtgttagttcatgcacacctgacaacagtttaactgagggagccagggc 1672 2437930 MEX3A NO ccctgggtccagtagaatgtataaaagttgtaaggaaaagataaatagaggagggaagtggctgagtccaccc- tgagttgcccaatcttcagataccaggg ttggatcaggttgctagtttaagattgggagcttccagtctgctggggttgattctgagaatccttggat- ttttaaattgtaggacaaagaaatgaggggttcattt cccagggtcttggaaaggatgcacactgatcatctcaataagacaggggctgggttgggggcagcagagg- aggccaagcacattcacctgcacccctag tacctgggcagcccatactccaatgtggta 1673 3264854 -- NO ctccacctctttttgtgcgagggcggcctc 1674 2701275 -- NO acttgctggaaaaagtacatgctctcc 1675 3017578 -- NO tatctctgatggagctagtgaacattaagccctcaatatttgtttaatcagtgctatcaaagtggtttaaatg- gatgtagtctccaggggtctctg 1676 3625878 -- NO ctacttcagtgagtgggactttagcctgagca 1677 2438152 -- NO cagctccctgagatagatgtaaatcctaagcattgtgggtgttttggtttgatgggactggattgaaagattt- acagacttaaattgtaaaggaaggtaatttaga gagaggaaggaaataaacattatgttggtttggttataaccactggcttgtctccactgacatggcctgg- gggtgagtggtgtatttgcaaagctcctttcaggt ctgcattaatctctggcattagttggctgtgaccgattagcctcccagttaaagtatgtagtcagttctt- agtgatggtaaatgggttactgaggccttcttattaca tccaattatgaggtgactatataatttatcttgcaaactgttgagtgtgttctaaacagtatgctgtggg- ggcgctatcactaattatgctgga 1678 2786550 -- NO gtacccaggaggtttggcatcactcaagaccctcagaatgcttcctctgctttaaatgcttggagtggctctc- tgtccaaactgtattaccccatccaaactaaat cacctctcactatgtggatgaagcaaacaacagatcttttgtttcgaaatgatttcatgttaactatatt- ccaggatattaagatcttacttaaggaaactgctttgc agtgccagggatctaagctatata 1679 3122495 ANGPT2 YES cagggacagccggcaaaataagcag 1680 3252241 -- NO cttctccgcaccacatcgcccttactctaaaattgaccacataattggaagtaaaacactcctcagcacaagc- aaaataata 1681 2806568 -- NO agagcactcaattcgactatccgtccagctttcacagaatttacttctgagcccacaagactcaaattgtata- aggatagagtctgtttcattcatcaacatatcc agcacctgacatagttttacatggcacagagtgggtgttcaataaatatttgtcaatgattgaacagaaa- ttttcagcaccaaatgaaagaaacacatgactttg aacaacggcacgagaataccaactgtttgattatgcaacgacaggatcttttggc 1682 3385452 -- NO agttcctaaatgggaacactgccttatgga 1683 3968192 -- NO gatcaacgcttaattcaaaaccaggctgtagaagaagaagaagaagagctaagaaggttcttagtgctgatgg- ggagaagagaaggttctggagctgtgc catccccgggtggaaagagggaatgtgttctttcttcccttgacacttctgtgcagatgaatcaggcagg- aatcaagagcggttg 1684 2397794 -- NO cttctgatcaccaagccacatgtgatgactcctgggcccttcttcctgggacaactgcaccagcttctaatca- gctcgcccatctcagcctgacccctctctgc agcctgaagtccagactctctagcctggcaccatagtcctttccttctctctgacctaatcattaaccat- aaccc

1685 2412877 ZCCHC11 YES cgatgtgacattggggatgcttccaggggaagtttatcttcatatg 1686 2904959 MAPK13 YES gtgggctgtatcatggcagagatgct 1687 3367083 -- NO acagactgacagaggtgcatggtggag 1688 2762520 -- NO tttaccatcgtttcattccatccatcc 1689 3463535 -- NO tgcctgtagctccatacctgtataatcaacagctattaaatatctgctaagcaaactaaactaagcattttca- aaagtaaacttgtgaaacctgatggatttcagta gttgacatcagcatctacttttgctgaagtcagtagcctggacattatttatgacacttatttttttttc- ccatcttgcccttatccattcattcaccaagccttgttgagt ttatcactgagtatctcattgccatcacaccaatctaggacaccatcatctcttacataggtgattacaa- tagcctccacactggcctccctgtctccgtttagctc atctcccaatatattttataaaaatgatactgttactttctctgctttaatggcttaccattacctttaa- atggagtctgaatcagtggtctccaaaggggggtgatat ataagataatctgctagggtgcaggaggaaaatattggaacttttattcatatttacctttttatttgaa- aaacactaaggcattaatatttaaaagctactactgtgt aatagttatttagtcattccttctttgctctatgtgtcagatggtcatttggtactaaaggtgtcctgag- ggaagcatgctttgttcactttctgcatgttgcacaatac tataatttgaatgtccatctatgcggatttatgagttatctagtttaactattacaaaatatgtaagtct- gggattagggaatttgtggagaaaatcaagtgtttaact gcaaataagatcacattgttgttcagctggtaagatatacaaaatcaaatctgttctcatgaattaagaa- aaattacgctgattttgaggttttaagtgaaacttttta aaaaattctcatttttttgtaaggcatccctttctgctttgatagccattaaaaatcaaatattcaaact- gatgttagaactagatctttgaatctctgtatcacacggt gttaagatcttcagaaataatgaagcatattcaatatttta 1690 3533262 -- NO tgggggagggaggatactactgagcaa 1691 3651809 -- NO caaagatgagaggtgcgaagttgtccaagtccaacagctcaactgaactttcctaagtggaattgtta 1692 3719905 MLLT6 NO ggttttgcatctcatttacttctccattggttcaggataaag 1693 3744442 -- NO ctgagcgtgccatctcccagtggcc 1694 3994048 -- NO gcaagcagcttgtcagacgtgcatgtggtttgga 1695 2566874 -- NO ttccctccaaagtggaagtgagctggagagatctctgggtctgaaagtcacctgctatgttggaggagggtca- ggctttttgaggactactctggtcaaggtc tgcagacttgatccctcctttaacccaaatcttattattatggctacacatgtgccacacattatagctc- cagatactcacgcaaggttc 1696 3788902 -- NO agtttcttttggcaggtggtccagaa 1697 2684832 VGLL3 NO aacacaaccatttacgatctcagtcagcagatttactctactcaaggaaaaaaagaaacaatcttattggaag- cagatgttgacactgtgtcagttattgaagac ggaaggagttcacttgagccattgcagttacaaaggggtattgatggcagt 1698 2808743 -- NO ggccaactgtcaagatgttttgaaggccaatctggaagtatatgttaaaataaagatgtgcataatttctaac- tgagcaactctactttgtggtatttatcctagag aaacattcacaattatgcccagagagatatatgtagggtatcccttgctacatggtttataacaaaaaaa- tatattagccaactagggtccattagg 1699 3311746 -- NO tttcctcagtgcattcttggtggtgagattgattggtgagcatcgtataacccactctgggagcatagcctat- ttgtatttgtgtatgtctatactttgtgaggtttag cccacttc 1700 2398939 -- NO atgaaatggtttggaaaggagcctt 1701 2948399 -- NO agagggcgatcaggtctcattaggccccagggtgtctgaggggtgatctctgccagtggcggtgggcaaggca- gaagaggcgtctgctgcagtggaag gatcatgacagcctgagttaaattccacctcttctcagctgtgaggtcttgagtaagtgattttgctact- ctgagtcttagttactttg 1702 2974531 -- NO tctcattttgattctggcagtgggcccaaatgctaagtgtcttgcccaaagtagaaatttccagttgctactt- ccatggtgtgccgcacaggcaatggctgagtt ctt 1703 3385006 CREBZF NO tctggatgattagcacatggataaaggagatttctggaatataaaatggattgtttttgaaatttctaggttt- ggctctatttactgtaatggttgaaaacaatttagt atttgggtgacccttttgtttttcttctaaatgtgcctctggtaaaatacagaactagactaaagatgta- gctttttaatatttgtcttttgatggtggcaggagttcata cattaattgaactaacacatcatattttgacctactatttctatcatattgacttactgtttctgcactt- ctttgaccagacttatc 1704 3777967 -- NO gcgagtgactccgtttctttggacctgcggttgagctggcagcagaatggaggggtccgagaaacgggtgagt- gtgaatcccttgcagaaatgctctctgg gggtctgcccttgaatgttaggcggcatgacaagtcaaatgcagtccaccagggtc 1705 2446212 TOR1AIP2 YES atggccgacagtggacttagggaacctcaagagg 1706 2527475 -- NO ccatttgagatgttctccgaggtgg 1707 3110892 -- NO ttggtttcaaatggacagcagcaaa 1708 3229044 BRD3 NO gatgtttctggtaatcatggacccttctcc 1709 3518549 MYCBP2 YES caggaccaggttctcggttgtcatctcctaagccaaagactctcccagccaataggtctagcccatcgggtgc- tagttctccacgctcctcctcaccacatgat aaaaatctacctcaaaaaagtactgctcctgttaagacaaagcttgatcctcctcgggaacgttctaaat- cagactcttacacacttgatccagataccctccgc aagaagaaaatgcccctcacagaacctttgagaggacggtcaacgtcaccaaaaccaaaatcagtaccaa- aggattctacagattcccctggatctgaaaa tagagctccctctccccatgtggtacaggaaaacctccacagtgaggtggtcgaagtctgcacctcaagt- a 1710 3701324 -- NO caaattacaattcaggttctgtttgaggtgctcctgagaagaggaaaagagtcagaaacctacacaaagatgt- atagaagattaggtcctgagag 1711 2941831 -- NO ttgcgtttacatgacttgagtggcctgtcagtcccgctagtaaagtctcctcatccatccactctgtttaaac- aatcaaactctgaaacctgtgtctcctggaccat cctataatccctaaaataggctgttatgcttttcacctctgccctactctgttagcactaccaacttatt- gacctctttcaatcaaatcgttatctaaaggatacctgt aactcagataggttgcctactgggcctgtttagtttta 1712 3403963 -- NO ttttttctgcactatggcttgggccc 1713 2337265 C1orf175 YES gaaaggcaacaacaagcagtcacagggg 1714 2774211 -- NO catcaggagtgtggattctgccattagtacccaacagatcaatgcccagtgtttc 1715 3626362 ALDH1A2 YES gcttcagaaaggggacgtctgttggataagcttgcagacttggtggaacgggacagggc 1716 3760869 -- NO gagcgtctctccttcaaatacctggatttttttttttttgtacactggttcatagatcggcacttgactttga- acctggcaccaaaaggcacaatatctgataccctgt acaagagctattagagatgctgccatatggatgggcaaaactgagccaatcccacttaggaatggaaggc- ttggacatggaagggaggatataaacgagg agttggagaaaaacgcaagcccagtttttgctagagtggaaatgaaagtgggaatgagggtcttgttttt- agtcctctaaggaccaggaagcaattttaaaact tccttggtttttctgaaagcagcatattcaaaatgccagcaaaaactcctaacaactgcaaaaccaaaag- aggatcaaagctcaccaacatcccttcttattgct gaaaggctctaaaattcaggatgccctgttcccttgtaaaagggaaaataattaagtctgatttatggta- atcataccacatcacacttctaaaaaaatattcaag tgtgtgaccaggggacgtttgacaccatt 1717 2772067 -- NO cctcaaagtgtctaggaggcggtttgatatgcagactaaagtgaga 1718 3350159 -- NO tttacatcatggtgtgtgacaaaacaattgcttccccctcctccctgcccttccccacccctgacttctaaga- taacta 1719 3946034 -- NO aggtctgcccatcccaaacctgggt 1720 2699092 -- NO gcttcaaacattggcccttcacgtacaacaaactctatcattcgatgtatcagggcgagcaaattcctacaac- aacaacacagttaaagaaaatggattcaga cctaccactatataaaactacacttgacctaagttactataattgtgcagaaaatgattattctgctgac- taacaccgaatttaataccaaaaaagtaacctggag catatgttaatgccttgtgcattaagagggtgtggggcagtgggagtagggaagtgggaggggatggaaa- ggtgagggagggtaggaaaccacaataca gcctcatagtaatatttaattttctaaatgtcacttattttccaaaagtaaaacattaaattataaatca- caactaattagaaagctgcaaatattgatatataaaatca gtaacttagagcctgcatgttattacagccatcta 1721 3027187 -- NO gttcacggcagctcccaacaggtctgaggtaagacgccgctattatcctcgtttgctgggagaagactcgggc- ttagagcctctgattacacagctgcactct aaccatttcctaata 1722 3496668 -- NO tctcatgtacctcgtagtatacctactatatacccagaaaaattaaaaattaaaaactaaagaaagaaataat- tgcaaaatgtaataatgtctttgaggggaaaat aaaaacttcagtgaaatactctaagaggggtttgatgcagagctgggggatgtgggaaagtagagatagg- aaagttgaggagggagggatgggttacagt ttgccaaggacagaattacttgagagggtgggagcaggacacacatgtcagggcctctggaacaggaaga- ggttggtttatggcagaaattgaaagaatg ctctcatacacagctcactttcctccttgctttttgtctgcatagcattattcaatatgtagcataatat- aagttgaaatcatatatcacctttgtggtcttctcccacca gaaatcaggcattatgaaggcagaagggcagaggtatttgtcgtgtgtgtgtgtgtgtgtgtgtgtgtgt- gtgtgtgtgtgtgtgtttgacttttgtatttttgctgc cgtattcctggtacctggaatagcacttggcagacaaatgtatgcaaagttattcaaatccagtgggacc- agaccacagtg 1723 3718614 -- NO cagtggggatgtagaatgtgtccaaa 1724 3759098 -- NO ggggcagcacaggtactctgattttggggccacgagggccaaatccgcgcctgcacgtag 1725 2721510 -- NO tattcctggactatagccgctgatctcattgatgcccttcttc 1726 2938424 -- NO ctcaagagtgaacccggaaaggctcctaaggaggtccctgcctcagtccaggcaaggctgtggcctagacgag- gtggcg 1727 3606484 AKAP13 NO tgctgctgcccgcatgggatgcgcaggggaggcgtggggatccgcaggagggtggttgggatacaccggatac- ctctgctctcattgcttgtttgcaaatg ctctatggacatttgtgtgctaaatccta 1728 3750237 -- NO ttcacccacatacaaaatagtgcgcgttttggctacttcagcctcttcccttctctagaaataactcctcctt- gtacttagtaaaggcacacattcacttcaagagt agg 1729 3320010 -- NO caggaggcccgaccaaaagcagatcaaataggagtgacagagttcagagctgcctgggacaaagttttaaatt- ttattttcactgcaacccataggaagata aacattttatatcatgacccagcacacaca 1730 3907649 -- NO aggaatgggccgcatggactacctgggggtccccaaggccccagctcctctcctttccgcgccttctcccaac- ctttattgcagcgtctcctccggcgagac gaggccgggcttagaaaaagggcagcgaagacccaggggccaaactggcactgaggagctctggtctctg- cgcggcggggcgccctctccgaatcag ccccaacaggcgtggcctccgggcttcaggcagcggggtaaggggccaggacacgggcacagggtctgta- tgtaaacggtgacagcggc 1731 2546923 -- NO ggctgtgtcacgtggacagtgtcacatctgcgggtggggataacaaggcacctgagtgcgtgaaggagga 1732 2788764 -- NO ccatgggaacagtcttgcagtgatggacggtttccatcccccatcactgacgcgggaataactgtgctgt 1733 2886332 -- NO cttttggcaaaaatgcgggccatggggtgtcaaag 1734 3307785 -- NO aacttcaaactgtgctcatgtgggcacagaagcatcgtgcagggctgcactgtcaccagccccagcagccaca- gggcagtttgtcaccagctccctgaga atcaactccagtgtgatggaggtgaccc 1735 2339825 -- NO tctttaagcgagaagtagatgtggggaggggttgttgcatttttaaagattcctgtattaggccgggtgc 1736 2922550 -- NO gtgaactttgtacttacgtgtgcttttgtggtagcaagtatcatctttctgtttccttttagcatttttggtg- tactggtcta 1737 3319874 IPO7 YES tagcgcacagtttgacatgtcaacaag 1738 3571362 -- NO tgggtactcgagcactgaagcattctcatcacttcccatgaagacactaatcccattaaactaggcattcctc- tttccctgaggttcgttgatagttgtatcttttgt catttcccatagtgggaaaactaaggtccgtggagggggatgtgaatccataatttctcttcaacaaaca- ggcagcagagccattgtggaatttctagcctaa gccataagatttgtggtttgtcctgatgtaagtgcattcactg 1739 2562256 -- NO acaggcgggtatggtaatagcaatctcaggagggctcttctgttgctgtgtagaaaatgaaccaagtagcata- gaatcgtgaccagctttccacacctggctg gagcactcctggggccttcagtagggacagttac 1740 2599272 -- NO ggaagttactgcttcccctggtgtctgttcttctggcttcagcttcgctggggatggattc

1741 3019543 -- NO gtggccttttaggaactgtagagtaacttaatataagagacattatttggtgggcagaattaagatcttggga- gccattgctggtgcaatcctcacttgggaaaa tttaacaaaatatagttagaccttttccaggtctcacccattccatt 1742 3316144 TMEM80 NO gagggccacattcggagcctccgtccactccagttttatcagcttttgccttttgcacggagtgctaaacaaa- ttctagctctgtgtttttttcccattcccagattt actatcagttctccttaaaaagtatctaagctgttacagtagctttcccttcacttgattctattgtgtg- ttttctatgtttggaataattacacccaaatatctagatattt tctcttcaccgcattttgtaaata 1743 3808909 TCF4 YES gtctatgctccatcagcaagcactgccgactacaatagggactcgccaggctatccttcctccaaaccagcaa- ccagcactttccctagctcc 1744 2360953 -- NO acattctatcagagagtacatgatatcaccatgccttatcattggtgaagttaaccttgaacttggttaaggt- gctgtctgccaggcctcttcactgtaaagttact gcttttccctcttcatactctgttcttt 1745 2458084 WDR26 NO cagctgttctaggatcttgtcatttttactgaaagtctcgtgcacatgtgaagtgccctctgagtttaaggtt- tggttaatactggtatatttttataagattgaaattgt gtccccatctttaacttaaacattttcattatcagggtcaatgtgctagaactgaattgtaacattttta- ggcacagatggaaaaaaatgttattggctccttgaaaa tgtgtgtgtgtggcgaggggaatagatccacaaaagcatgtatgtacttacaaaccaagctgtagagatc- aagaaaagaacttaagtgttgatctcaagatttc taaattgtcaagatttacatggcattgtggtggaactagttaac 1746 2775432 -- NO tggagaccagataatggatgctggcaagatctgggaatcaaagccatggaaagggtgccattggtcag 1747 3577885 DICER1 YES tagataatatgttaatggggtcaggagcttttg 1748 2413468 TMEM48 YES gctggaggatagttgcaagtattgtttggtcagtgctatttctacccatctgcaccacagtatttataatttt- cagcaggattgatttgtttcatcctatacagtggct 1749 2478883 -- NO tgaacagacctcaatgtcagacaagccaggggagcctgc 1750 2783808 -- NO atatttttaatggtgtcagccaggcaaa 1751 2406967 -- NO ctcctgtgactcagagccctcggctt 1752 2436718 UBE2Q1 NO tgctgtatttggatctcacgctgcctctgtggttccctccctcatttttcctggacgtgatagctctgcctat- tgcaggacaatgatggctattctaaacgctaagg aaaaaaaacaaacacagaactgtttcaagtactcaagactgacttacagaccaaccaaccaccttgctgg- aacccttgctagcaggcattcttataaaagaaa ctttcgagcctccttatattgctggaaactcagctgtgctccagactagagcctccttacctatgctatg- ga 1753 2663594 -- NO ggcatcttatttcacgcaccacaggcccttgttcttcccagatgtcagcaggctttctccaataaatgcttct- tcatttgctgttgcccttggaatcatcccagaga ttttaaacggctgtgtgtatgtttcatggggaagtctgtggcctccttacactgtcctgcagaactggca- cctccggctgtttt 1754 2854791 -- NO tttagaattgactgaggagcggccgggtgcggaggctcacatctgtaatcccacacgccttgggaggctctga- ggcgggtagatcacctgaggtcaggag tttgagaccagcctggccaacatggcgaaaccccgtctccactaaaaatacaaaaattagccaggtgcag- tggcacacacctgtaatcccagctactccga aggctgaggcaggaggatcacctgagcccaggaagttgagactgcagtgagctgagattgcaccactgca- ctccagcctcagtgacagcgagactgtct caaaaaaagaaaaaagtgactgaggaggaagaggccaggtggcaaatggaacagaatcaccaaagggtga- acaggactaaggcaatgtagtgtatgg ctcagctacgtcagagtggaaaaggtgttattagagcagaaactatggtccctgcgtcacagggaagcaa- cctacagagaagcagcagctccccaagag aggagagataagaagccagaagcctcagagtgaacaattgtccta 1755 3350791 SIDT2 NO tcagagtttggtgtattagaggaactgccagttgttcatactggctaggcagggccttacatttgaggggaga- agggtgagagattgagctgggtggagga ggacatgaaggcctttgggtgccat 1756 3447872 KRAS NO catcttcagtgccagtcttgggcaaaattgtgcaagaggtgaagtttatatttgaatatccattctcgtttta- ggactcttcttccatattagtgtcatcttgcctccct accttccacatgccccatgacttgatgcagttttaatacttgtaattcccctaaccataagatttactgc- tgctgtggatatctccatgaagttttcccactgagtca catcaga 1757 3709501 -- NO gtccagtgcctcataacatggtctcaagctcttaacaaatggagcccaggattcaaaaatctgaactctaata- atggcttgtcattctggtttcttacccttgagg aacctgtgaggtgttaaccaacctgtaagctgcattccagcactggcaaacctggcctctcaaatatcca- gccaattctaagtttggtgccagga 1758 3606344 -- NO gaaaaaattgtcagttgcagggatacatttctcactaatgaagaaacatggaaaatatctgtgtaaggggatc- acgctgtttcttaagttcagattattggaaga gggtggtgatgtaggtgtgtactcttcctgaggttg 1759 3884906 FAM83D YES ttctgtctggccaagtggttgaacactttgatctggagttccgaatcctgtatgcccagtccaagcccatcag- ccccaaactcctgtctcacttccagagcagc aacaagtttgatcacctcaccaaccgaaaaccacagtccaaggagctcaccctgggcaacctgctgcgga- tgcggctggctaggctgtcaagtactccc 1760 3919041 SLC5A3 NO ttggaaacagaaacgaggcttattgctattgcagaaatcccaaactggcaaaggccagtatatatggtattcc- ataatataaccagcttttgaaatttatgtgttt ggattagtgccttctggttaccagtattgactctgctagtttgcacctttccgttctta 1761 2847683 -- NO ctgggaggctttcagatgcagcatccaccaaggaatacaccgactaacacacatgacagcctgaactagcaac- ctgcatcaacacccctgcagaaaagca gtgcatttcaactgctcatttaataagtatttgaattcataattacaaaacatcttctgtaattaaacca- ccatatgcatttaaaatattttggggacaaagagtagca aagaattatattggatattgactaaaaacacttatgaatatcaataatttgctcctcctcccttttcatc- atagactctttacaatgatactgaccttggggttg 1762 3776975 -- NO tttgcaacccaacctgctggaagtgcaaagttcagaccagcagcaagaactcttgccccatgcttctgctgac- at 1763 3543413 RBM25 YES atctcgaaccagtggagcgcactcgtaacctggatcccagaaggtcgcgaaggcagtaccgtttcctcagcgg- c 1764 3653407 -- NO ttgagtgtggtagtgtccgtctgtagtcccagcaactcaggaggttggggcaggaggatcacttgagcccagg- agttcaaggctgcagtgagctataattgc accattgcactcaagctcaggcaacagagtgagaccttgtctcaaaaaaaaaaaaaaaaatttaaacaag- cgacagtaatatttcattagaaatgtgatgaat gctatgaaggtgtagaggatgtctttagaatatataactgggagggagaccttttgagttaaggcaggtg- ctggtcaggaaagtcctgaggaagttacatttg gattga 1765 3670580 -- NO gtgaaagactaaacagacgacttcaaaactctcatccaacatccaagagttctgccatttccaagattcagca- atcctc 1766 3767260 -- NO taccagttagtacaaagatcacagccaatatagaacctaaaagtattcacaatgaaaatgacaatgtagttgt- cgttttgagctgcatggtacttaaatctg 1767 2456432 -- NO cacctgctccgagggtcagggctaagtggtttgagcaagtggcaagctcacaggtccagttggctgagggcct- gacccatgacgatccattt 1768 2750681 -- NO tatgacactgaatacgggaaagtgatgggagtgaggctggttaaaatttttcacccacgcagtctccctgtgt- t 1769 3071991 LOC653852 NO cacgtggtcactgacactcccatggc 1770 3436046 ATP6V0A2 YES actcggatccgcaccaacaaattcaccgagggatttca 1771 2383133 -- NO tcagccctgtgaagatgtcattccattatcttctgtcttctattgtttctgtggagatggtagctctcagaca- aattgttggttgctcgtttgtacatactccccactcc catcctgccctgggtactctaacattttttcactttgtgtttagtttcagcagttttaagataacgtgcc- taggtcgggc 1772 2434773 FAM63A NO actttccagccgcagagtagtgcag 1773 3338526 PPFIA1 YES gtttggagcaatgatcgagtgattcgctggatcctgtcaattggccttaaagaatatgcaaacaatcttatag- agagtggtgttcacggagcacttctggcctta gatgaaaccttcgacttcagtgcactggcactgctgttacagatcccgacgcagaa 1774 3671856 KLHL36 YES caggcagacgcgagtgtctcggccatacaagatcagcgaatcatca 1775 3060641 -- NO ctcccatggctggataaaccaaatctgatacatccacatttaaggttgttttccaagttggtttccataaaag- gcctttaacaataataggcttttaacaacaaaaa ggtatccctcccatcacaatgagagcttgatgagggctcaaaagtgacttcaaaaactgtaaataattat- tttccttggacggctttaaaaacagctactgatag caaatcagaaacactaaagaaaaaagacaataaggaaacagctgtttgtctagtgaatccataataaata- ccaatttgaggctatagattacaaagccaaaat attcttataggaaagttaatgtttatatttacaatcccatggactaaaaaaactgtctaatatcttaaag- actg agtctacctttatttaacattgtttatacacaaaga cccaagggatggtagaattcttgatccttctggacaaaagcatagtgagaggggactgaaattaacaaaa- agggaaaattaacattaatctcaaaattctacc catcgttgtcttaaaatgatcaagactcagctacatctgagaaaaaggaaaaggatcagaagtgaaagaa- atcagaagccagtaattaaaaaaatcataacc ttgtgtgctttctactgacggcatttaaa 1776 3379623 MTL5 NO ctgtgcctaggctgttgacaacttttgctgagttggacagaataagactgtgggccatgctgcttgcttcact- ctctgggtgtgatggatcggtgagggtgcag ttgctatgattgtaattggtcatctcatcatggctgttaacatttctggaccaaacaaaaatgacttcag- ctacttccagattctgctgatacattacacaggatgat ctaaaaggctacagttctgaagatactcatctttcttgtaatctgggggcatctggtcaatagtattgcc- tctgtgctgtattgtgtctagaacattcaaggacattt gatacttctcatactttaattgcgtgctctcccagttgcagcaccctctgaggcttctatgtgttgcagc- cgatgggcatttgcacagagcagcagtcatgacag cgttttcagggcagctatttctccttttcccccttttcctctcccccggcttcccattctcctcctcctc- cttcctcttctcgtcccctcctcctcctctttgttctcctcc ccctgctcttcttcctctctccttttcctccttctgtgtctatactagattattttcaatcagtcacatg- tttttctttattttgaatgttacaaaatatttctctattgtaaacg gtgtgccaggaaaaacatgagatgtgtatttgtattttttatgcacataattacttaatccaatgcctct- ccacttaattgggcctgatga 1777 3547548 -- NO ccagtgttgggtgcaaatatacctaggata 1778 2779848 -- NO atgagaagggtattggatacgattaggttagaagctcctagctcctcagtgaagtggtacataagggctctct- ctgc 1779 2869655 -- NO ttctttttctaccctcactgtcctct 1780 2964686 -- NO tctgagcacacctgtccagagagctc 1781 4004181 DMD YES ccttcagaaccggaggcaacagttgaatgaaatgttaaaggattcaacacaatggctggaagctaaggaagaa- gctgagcaggtcttaggacaggccag agccaagcttgagtcatggaaggagggtccctatacagtagatgcaatc 1782 2432028 PDE4DIP YES atgtctaatggatatcgcactctgtcccag 1783 2443375 F5 YES tactcaagatcaagaagataacggcaattataacacagggctgcaagtctctgtcctctgaaatgtatgtaaa- gagctataccatccactacagtgagcaggg agtggaatggaaaccatacaggctgaaatcctc 1784 2736714 -- NO ttccagagtttgcagggacagttagagtcaatatgaattctcagaataagcactgccagatagtccggaagcc- ctttacaaggaaagtgacatttttgctgtgtt ttgaatagtgaacaagaatgtgcaggaagagaatgaaaggatatcactagcagaagaaatgcctctttgt- aaaaccatagaaaataactctgagttgccatat aggacatatgagaatttcagtgttactgaaacaaaagcttttggaaaaggtatggtgattaaattgggta- tacaatctgaaaggtaaattgaggacaacttgtgt gccagtttgca 1785 2969491 -- NO ttgtagctgttagaagggatagttctacaaggtatccaaatttcctaagtatatttctttaaattttcctttt- attgaattttctgtttactggcattagtctcatatcagttt tggctacctttagctgcttttgttgaattctatttaataaaggcactgcaagtataaaattattaaaaat- agacaagcacaatcctttctctgctaaacaagcttatga aaaacctggtgatacccaaagagctacaaaggaaactctcacacttg 1786 3417650 RBMS2 NO ctgcacttgtggaacatcacatggcaaaaacaggagttttttcgctagactttttttttctttttaaccttat- taaaaatgagattggtcctaa 1787 2586174 -- NO ctttgcttataatgttctgtagtgctgatggactgcctgattgtaga 1788 3777613 -- NO aatgctgcaggcatcagtgggagag 1789 3888166 CSE1L YES tgacatcccgtcttcctatatggccttatttcctcatctccttcagccagtgctttgggaaagaacaggaaat- attcctgctctagtgaggcttcttcaagcattctt agaacgcggttcaaacacaatagcaagtg 1790 2332174 CTPS YES tgaattctcaagaaacgtgctgggatggcaag 1791 2684865 VGLL3 NO

agaaccaactacagtcacctctgctacctcagcatgggctggagcctttcatggaacagtagacatagtgccc- agcgtgggattcgatacag 1792 2756426 -- NO aggcaatggcgattttaggctctccaggtgattacaatatgcaaccatgctcccaaatgtctgctgtaaacca- acatctttcggaggaccagttgaaaataatat ttctcaaattaatgtgaaaagtgtttgctgttgagttgcggcctttcagtcccgcctttgttctctactc- accactgttgagttgtggcctttcagtcccgcctgtgtt ctctactcacctctactgcttgttttgctcctgattcaaaccagttccacacatactaagcccactgtgc- taggtggcctgaccgtggtgaatattattgtggagg aaggactttgctgtaagaaattgcattccccaaaactgaaaccatgatatttactcaactgaggtaaaaa- atgaaagactaagggggactcccaagggtcag ggcaagaataaataccttggaatattaatacccatctcatgatgcctgagtgtaaatgctcc 1793 3309131 C10orf46 NO ggaaatgctaatttgagcttcattcataggggaacctactatatattgcatccctgctggttggaaattatct- tcatctctggactgcattgtttagaaaaatgttaat ggcttacaattctgagaactttattgtgtggctctg 1794 3435688 ARL6IP4 YES ctgacggatgagcagaagtcccgaatccaggccat 1795 3544550 LOC731223 YES tggaaagctttgaagacggcggttctggg 1796 3737293 KIAA1618 YES tgaaggcattgtctgcatttccaagaagcacctagataaatacattccttacaagtacgtcatttataatggg- gaatcttttgagtatgagttcatttacaagcacc agcagaagaagggcgagtacgtcaacc 1797 2769855 -- NO ttagtttgggtctgatctttgtttc 1798 2914869 -- NO cttccttgtggaagttggcttgatg 1799 2754682 -- NO acagagcccgagcttttgtcctgcaggctcaagcttctagattcgtcttctcgttaatgcggggacggac 1800 2353146 -- NO ttccagcaggcaccgaaaaagccctgtgagcttctctctgagcggtggagaactgcacatgtatggatgttgc- tgcttcc 1801 2685210 -- NO atatttgagtgtcttattggacttggaacttccaccagtatctccagaattattgtctgtctgcag 1802 2774664 -- NO agttttggttccgacaagctgcaccattccaactgcc 1803 2517907 -- NO tacacaaattgaacgcggtagggtgggggaggaagtagggagataaagcctatgctgctgattcctcaattat- aggagcagtctctaaaagccctcgtcaat ctagtgatgtgt 1804 3156168 -- NO gtgcaagctgtgtagtggatcattgagtgt 1805 3359979 NUP98 YES ggactctttggaaccacaaataccacctctaatccttttggcagcacatctggctccctctttgggccaagta- gttttacagctgctcctactgggactactatta 1806 3701355 -- NO tcaataaaagttgtattgagatgtgattcacatactgtacaatttatccctttaaaatatgcaattcggtagt- ttttagtgcattcacagagttgtgcagccattatcgt aatcagtt 1807 2329396 HMGB4 YES gtcagctagaaaccggtgcagagggaaaag 1808 3290788 CCDC6 NO tccatgctcaagagccattgtaagagattaaggggtttctaggtttttggtgattttttgtttgtttttttct- ttgttttttttgggtttttttttcttctttaattttttgattaaaa catacacacagctgttagcataaagtcgtggggggcattttctggaatgctcagcagttctgattaactg- ccaagcccaggttgcctctcatgaggcaactga aaaaatcctgtgtcttgatagcatgggtgc 1809 3449856 -- NO ctttgactccattgtctgctttggct 1810 3573894 DIO2 YES aggggaaccagagcgcacaagggaa 1811 3670649 -- NO ccacgttgtcaagcacagaactataaaaacaatggattcagtgggtgaaggtaggagaaggggttcaagagat- tcagacttacagtaggaaagttatttttcc aatctcagtaagttttttagggttatgaagattgagcactgacgacgctgaaataccacagtgcaaatgc- ttccgtagattccctgggctctgcactcaccagat ccatttctatgataaagcacagagctcctcaaacagaacagtcgagttgcaggctcagcagcctccttgt- cagtgtcctgctcaactcagc 1812 3851066 -- NO tgcagtgcctggatcataactctggatcatcactgaaacct 1813 3912092 SYCP2 YES tccttgggagacctggcaaaatgaat 1814 2626159 RPP14 NO tctacttttaatcaggcgtggcagc 1815 3448099 BHLHE41 NO caccagctgtaaaagatcctatgcgaaagacactggctcttttttttaatcccccaaataaattttgccccct- tttaggccatgttccattatctcttaaaattggaa cctaattcgagaggaagtaagaagggtctgttctgtggctgagctaggtgaaccccggggtaggggaaag- atgttaacacctttgacgtctttggagttgac atggaacagcaggtagttgttatgtagagctagttctcaaagctgccctgcctgttttaggaggcgttcc- acaaacagattgaggctcttttagaattgaatttac tcttcagtattttctaatgttcagctttctaaaaggcatatatttttcaaagaagtgaggatgcagtttc- tcacgttgcaacctattctgaagtggtttaaatggtatct cttagtaacttgcactcgttaaagaaacacggagctgggccatcgtcagaactaagtcagggaaggagat- ggatgagaaggccagaatcattcctagtaca tttgctaacactttattgagaaattgaccatgaattaatggactcatcttaatttcttctaagtccatat- atagatagatatctatctgtacagatttctatttatccatag ataggtatctatacatacacatctcaagtgcatctattcccactctcattaatccatcatgttcctaaat- ttttgtaatcttactgtaaaaaaaagtgcactgaacttca aaacaaaacaaaaaacaacaacaacaaaaaacaagtccaaactgatatatcctatattctgttaaaattc- aaaagtgaacgaaagcatttaactggccagtttt gattgcaaatgctgtaaagatatagaatgaagtcctgtgaggccttcctatctccaagtctatgtatttt- ctggagaccaaaccagataccagataatcacaaag aaagcttttttaataaggcttaaaccaagaccttgtctagatatttttagtttgttgccaaggtag 1816 3872452 ZNF552 YES agcacgagagactgctccctacagaagaaccttctgtgtggtgtgaatgtgggaaatcctctagcaaatatga- cagc ttcagtaatcatcaaggagttcacac tagagaaaaaccttatacgtgtgggatatgtgggaaattatttaacagtaagtcccacctccttgtacac- cagagaattcacactggagagaagccatatgagt gtgaggtttgtcagaaattttttaggcacaagtaccacctcattgcacaccagagagttcacactggaga- aaggccatatgaatgcagtgattgtgggaagtc atttacccacagctctacattccgtgttcataagagagttcacactggtcagaagccttatgagtgcagt- gaatgtgggaaatcttttgccgaaagctccagtct cactaaacacaggagagttcacactggagaaaagccttacgggtgcagtgaatgtgaaaaaaaatttagg- caaatctcttcacttcgtcatc 1817 2489627 POLE4 NO gtgttctgcataagtggcttcctga 1818 2934111 -- NO tcaagattatatatggcagatgaggataa 1819 3181290 TMOD1 NO gtaatggcccagcttagagacttcagctactgatctcatcacttattagacaaattgctgctgaccttacgcc- tgtatattaagcctccgcaggatgccggacaa tggtgaagaaactccagatatcaaggaattgggaaatcctggccaaaccaccccaagatgattacactga- aatgtagtattagtactgctgccagatctcttttt aacatcatgtgcgtctcttgggatccagcaaaagtgttaagccacaatgcccttgtgccttttaatatac- cacagtgccagttaaactaatatttttgtttgttgcttt tgggagttattttcattagtgatttcagcaaatctcatgataaaggacaaggtcaagaactccagagcac- tgagcagagaggctggtgatgaaaaggtgaag gcctgcgcactgaactgtaa 1820 3487237 AKAP11 YES aatgttccctgtgccaagttcacaagtg 1821 4009127 JARID1C YES tgagtgtccccccacagtagtggtgaaggaggagttaggtggggatgtgaaggtggagtcaacatcgcctaag- accttcctggagagcaaggaggagct gagtcacagcccagaaccctgcaccaagatgaccatgaggctacgga 1822 2750647 -- NO tgagtacagcccactgattgacattcaagacccattggaaaaatcaggagacacaagagtgggaagagtgcag- attggagcagctatccaaaaataca 1823 2916198 ZNF292 YES gggctggacttgctacctgtatagaactgtgtgtaaaggctcttcgcttggagtctacagaaaatactgaagt- gaaaatatctatttgcaagaccatttcatgttt gttgcctgatgatctggaagttaaacgtgcttgtcaactgagtgaatttcttattgagcctacagtagat- gcgtattatgctgtggaaatgttgtataatcagccag accagaaatatgatgaagagaatcttccaataccaaattctttacgctgtgagctgttacttgtattgaa- aactcaatggccctttgatccagaaactgggattg gaaaaccttgaaacgacaatgtcttgcattaatgggagaagaagcatccattgtgtcttcaatagatgaa- ctaaatgacagtgaagtatatgaaaaagtggta gactaccaagaagagagtaaagaaacttctatgaatgggctttctggtggagttggtgctaattctggcc- ttcttaaagacattggtgatgaaaagcagaaga agagagagataaaacagttaagagagaggggatttatatctgctcggtttaggaattggcaagcctacat- gcagtattgtgtgttgtgtgacaaagaattcctt ggtcacagaatagtacgacatgctcagaaacattacaaagatggaatttatagttgccccatatgtgcaa- agaactttaattctaaagaaacttttgtccctcatg tcacactgcatgttaaacaatctagtaaagagagactagcagctatgaaaccattaagaagattgggaag- gcctccaaagatcacaactaccaatgaaaatc agaagactaatactgtggctaaacaggagcagcgacctataaaaaagaatagtctctattcaacagattt- tatagtgtttaatgacaatgatggttcagatgatg agaatgatgacaaagataaatcctatgagccagaagtgattccagtccagaaaccagtacctgttaatga- atttaattgccc 1824 2984592 SFT2D1 YES tggcttccgggcggcataaagctttttgcagtgttttataccctcggcaatcttgctgcgttagccag 1825 3123564 -- NO cagttcattccgtttccacctggcagctgctccctctgacacccaaggactcgcagggagtggccgttggacc- tgcagacc 1826 3165879 TEK NO gtagcagccagtcccgtttcatttagtcatgtgaccactctgtcttgtgtttccacagcctgcaagtcagtcc- aggatgctaacatctaaaaatagacttaaatct cattgcttacaagcctaagaatctttagagaagtatacataagtttaggataaaataatgggattttctt- ttcttttctctggtaatattgacttgtatattttaagaaat aacagaaagcctgggtgacatttgggagacatgtgacatttatatattgaattaatatccctacatgtat- tgcacattgtaaaaagttttagttttgatgagttgtga gtttaccttgtatactgtaggcacactttgcactgatatatcatg 1827 3887555 -- NO tccattccaggattggtgctgaagcacatgtgtcctgaagttcaggacgtcagggtaattgacacagaagaaa 1828 2356740 -- NO tataatctagaaacattcttcagcgttttttttctttcattacatgaagagtcaagaccagtggttttgtgga- atgcatgataatctgggttcttaaaaatcatttcttctt gattagatttcccattgtcttgaattgactcagtcagcctttcctcaccgctactccaggttcactaatg 1829 2665536 C3orf48 YES gagaatggataggcttttaggtcttggaagaaaagaagtgtccagggttcaatggagtggctgctct 1830 2833553 -- NO ttttggggatgacattgtggaaagtttaccctca 1831 3242698 -- NO tgtaatacctcatcatagatatttggggtgcccttca 1832 3911222 PMEPA1 NO gaagttctagccactcgagctcatgcatgtgaaacgtgtgctttacgaaggtggcagctgacagacgtgggct- ctgcatgccgccagcctagtagaaagttc tcgttcattggcaacagcagaacctgcctctccgtgaagtcgtcagcctaaaatttgtttctctcttgaa- gaggattctttgaaaaggtcctgcagagaaatcag tacaggttatcccgaaaggta 1833 2676501 -- NO attgaagaaccgctgctggagaact 1834 2839345 -- NO gcagccttattcagcaacgctggggatgacaacatg 1835 3239038 -- NO gaataagcagaaacggctgggcgtg 1836 3475695 ZCCHC8 YES cctcggaatgctgctcgaataagtgaaaagagaaaagagtatatggatgcctgtggagaagcaaacaatcaga- atttccagcagcgataccacgcagaag aagta 1837 3563672 -- NO gttctgaggcccagcaactctgaga 1838 2333149 CDC20 YES acctgaaccttgtggattggagttctgggaatgtactggccgtggcactggacaacagtgtgtacctgtggag- tgcaagctctggtgacatcctgcagctttt gcaaatggagcagcctggggaatatatatcctctgtggcctg 1839 3740914 -- NO ctggtgaggagccgcaactgggcatctcc 1840 3949524 -- NO ataaaacatctttgacgtgggagctgcagtactg 1841 2598329 FN1 YES cattgtctccaccaacaaacttgcatctggag 1842 2354732 -- NO gggtgtcatggaatcttaggagccctgcattccaattgcccaggctt 1843 2534399 -- NO cagaatgatggagtttgcatggcacagt 1844 2677654 C3orf63 NO cagtacctgcgcaatccttgatttaatgaaattaaattttttatttcaaaagataggcttctgtttatcaaag- gcgttgaacaatttgatttttaaattagattttgcaaa atggaagtataatgggaatatatttttgaggtggtcttagtagtaattaccatttgttgaacacattaat- gctatactagacagatacagtggagatagctttcaaa cccgtatctattcctaactactgcctctaatactaattactaacttgttactaatgctaacttttaaaaa- tgtttttgaaaattgcaatttctacaaataaatgtcatagtg caaataaatgtcaggatttagagaaggagcctaaactgaatttgtgttatttcagtaaaagttatggagt- tatgggtctagacgtgttaataagttagacagaact ttggcactttagaacaaatgcatgagtggtatttcagttcctaagttacataaaaagtgtgaaagaacac- tgtgaggtcccagcaacgccagactatattaagg taagtagaaagtgtttttatagggcttcaatacccaggtggtgacagagcagaagaaccggttttttttt- ttttttttttactactaagcttttacaaaagaagtatctg ttttattgtatagaacaagtacagcattttactacatagtatacaagtttttaatgagcatttaaaaaaa- taagtaaatctaggctatttgaaaaatacagttgagcca

gtgagcacattttataatttggaagacacaaatcaaatgtgaaggatttgattttctacatttaaaatga- agaaccaaaactctcttcttgattttcagctaaaggca ggagactactttccaactccttttgcttctggagaaggccctgaaatcacattgatatatgtttgttagt- aaaatgtgcacacctgacttgcaatgttgtgttaaact agaattatattcacttggaaaacatatcgcttaggataaaattttgtca 1845 2495347 -- NO agaaagtcttaatgggagagtgcccatggtatat 1846 3436411 -- NO caccatccttgaggggtcgagccaggactggaacctcagtccggccactacaacttcataaataccatcgccc- tgagatgctgaaatcccaggggccccc caccctcagaccaggtgccggtattg 1847 3630941 -- NO tccctggtatgtacacgcattcctgtgttttgtgaaaaaccgacaccatgctcctccctcactacatgtaaaa- cacttttattcattaaaaagaaaactgactggct tggacctacaaattagtttcattatttgttaatgtttgaaagccattaaaagatgaatattaaggtttct- ttatactcaatacttgtagttttgtttgggggaatgagag gatgcccttggtacctttgtgaggcctctccactgagggtcaatcatgacttctgttttaaaccagccca- tcccatcttctccagctgctctccttatgtcttgcttct ctcccctccaaccttctcagcataaggactcaatcctaggctcctaccccagacgggtgccttccaacgt- tcctggtgc 1848 3886257 -- NO cacttgggttggaaactctggcttctttccccccatggcctgtttggctcacaggtgccaccagcctcacctt- gatccactgtcacttgtgcttactcggtgttag ctgctttgcctcctttcagtccctcgaaccctgagctcttctcagagctcctagtgctcctctgtcggcc- tgcagtgcactcccgcttgtgcctattgtgta 1849 4004292 -- NO aggatgaattctcaccaaccatatattattttccgataacagtgtttggtagtgagggggatctattgctagg- taaaatacgatggattcaaggagcttactgtttg atgatagggcaagatgtgttcatggatactagattgaga 1850 2960481 -- NO ttggagccagtcaggcttttgtttagacattttaactttttcttgctttccttgcaaactcctcagccttcag- actggttggaaagtaaatgtacaatcttacataaattt tcaggtaatagcatttcagctttttccccaagattttttgcttgggaggagacagattagactggattcg- gagtcttgattttgcaaaggtaacaaaagacatgttt ttttataagacttttcatcataagtttattttattcaacagaagcaaaatctaatataatggaaaaaata- aagatctgtgataaatctgatctgtgtggataaacacaa ttagaaagacttaaagattaagtattgaaacaaactaccaaaatattttaatactgatttgtaaaaattt- cagtacatttttctcttgcttaattctactgggtcctgttt 1851 2977359 -- NO tagtcattggtgaagcaggattccaa 1852 3199214 -- NO tcaggcttctgttgcaagccaatgtagggaacca 1853 2743060 -- NO ttcctgagttcaagatatagttaagtttaaataataggacttgtgtatgaattggatggtgtgggagggaaat- caaaagttctgggccgggcgcagtggctcac gcctgtaatcccagcactttgggagtctgaggcgggcagatcacaaggtcaggagattgagaccatcctg- gctaacacgctgaaaccccatctctactaaa gatacaacaaaatccgggcgtgg 1854 2811122 -- NO aggagttctccacatactctgcccaccctgatagcaactgaggtaggccagaaacactcatgcactggttacc- tcctgagccatccacagaaagggtca 1855 3560070 -- NO gtgtgatcaaaaaagtggtcagtgtgaa 1856 2597541 -- NO acattgaaattcaagatgcaggcagagaaagaggacatagaccagat 1857 3747622 -- NO gcgcgtgctcaacttggatgggacacacctagtctttcttcaagtccctggattcaaagagcttcaaccgttc- ttgcaccgtcaggc 1858 2332216 -- NO ttgattcatcctatccgtgagcgtgg 1859 3029849 -- NO gctggcaccccagaagaagctagctcagcatgtgcgggtc 1860 3090304 ADAMDEC1 YES atacattgatctctatttggtgctgga 1861 3441298 -- NO actatctgaaaatgggcaggtggtgca 1862 3584491 -- NO tgcgatctccgctcaaaaagatacttttgaatccttttcaaaagtaatttgtgtttcattttttaattagtat- gataagcacttcaagaccctttacaattctggctagat ttggttgccatatttaatagcattttataaataatggagaaaagggaaacattatgcatgcttgattacg- gtcatgagctgcattaacaattccgttcaacaacaga ctgcatatgtcagagcagtcccttaagattacaaa 1863 2775809 SEC31A YES gtaaactttgaggatgattctcgtggaaaataccttgaacttctaggataca 1864 3380586 SHANK2 YES tttcgatacaagaagcgggtgtataaacaagccagtctcgatgagaaacagttggccaagctccacacgaag 1865 3410510 -- NO tgtgtcccgcagctcaatcagacttctggatgccatcaaggaggtctgcatgacctaaggatcattgttcttt- gaaaggaaaacaagttcattaatcttactggc tgccagggttaggatgcaaagttaatcaattattagtgactaccgtctaccgaatgactacgtgcaagca- gtcatgcatggaggaagaaaaggacaaagag aaaggaaaataagtaaaaaacaaacgtttaatgattttgataatataggctcagttacatcaccacaaac- a 1866 3266758 -- NO gttctggaactcttcacacctgtgacctgcat 1867 3878506 SEC23B YES gaaactggagcacccatcctaactgatgatgt 1868 3189392 -- NO tgcaagattcttggatcctcgtccggtacattttggctgcattttatgtgacgtttgtgagggggttagaaat- actttaaaatttcagggaacttgaataacaatga aagatgtgcagctagtccaaacagatggacttcagtagcaattccaggggcgtttc 1869 3737624 KIAA1330 YES ctccctgcagaagcgtcccgacggccacatcgtgagtgtgag 1870 2587558 SP3 NO tagccgctctcgaaaacctacgctgccacggccgctcattgtctctccccttccacccgggggcaaacaggaa- gcgcgccgcctggcagaccgacggac aggcgcctggaccaatgagcacagccgacaaagagcacggcggcgaatga 1871 2636399 BOC YES gccctacgtggtgtcgggctacagcggtcgcgtgtacgagaggcccgtggcaggtccttatatcaccttcacg- gatgcggtcaatgagaccaccatcatgc tcaagtgg 1872 3383004 RSF1 YES aactgccagtcatagtgaagctagaaaaacctttgccagaaaatgaagaaaaaaagattatcaaagaagaaag- tgattccttcaaggaaaatgtcaaaccca ttaaagttgaggtgaaggaatgtagagcagatcctaaagataccaaaagtagcatggagaagccagtggc- acaggagcctgaaaggatcgaatttggtgg caatattaaatcttctcacgaaattactgagaaatctactgaagaaactgagaaacttaaaaatgaccag- caggccaagataccactaaaaaaacgagaaatt aaactgagtgatgattttgacagtccagtcaagggacctttgtgtaaatcagttactccaacaaaagagt- tttgaaagatgaaataaaacaagaggaagaga cttgtaaaaggatctctacaatcactgctttgggtcatgaagggaaa 1873 3959450 -- NO tgtttttatcacagggccgtcgttgaagcatgtatgactatgtgtgtgaaaatgttctgcaaaccaaaaaggg- ctcaggtgctataatt 1874 3984482 SRPX2 YES gatgagatgccacgcactaccattcatcactagtggcacttacacctgcacaaatggagtgcttcttgactct- cgctgtgacta 1875 2333884 -- NO ttgtagagtatgaacactcctttactttcagcaacgtcggcatctccaaataa 1876 3392870 -- NO atgcatgagggcacgcctcctactttc 1877 2395894 CLSTN1 NO gccgcgcggtttcccttcgcagatgtgtat 1878 2701311 -- NO attgagcctgcccatcatgcattgcaacaggaaggtggatttgaaaagggaaaagaattaaaacatcccatca- cacgtgtaat 1879 2976681 -- NO cagatacgggtgtgtacttgaatcaaggagaggcagtagagcagccttatgttttgttccccaaagagtgaga- tgtgtacccaattcttgcacatagtgaaga agctgttctcttttttgttgtttgtcacatctgattattcatggagaaagttgcagcttggggctagtaa- aatttttttttaacaccgttctcatattatttgctctcttctttt aataaaggacagataggccttgatgtggctgtaa 1880 3398768 -- NO gcaactttcagtggaggcgctgagagcaaattgcagcagagatgcgctcagggtgcagtaacaaggaaggacc- cgctctccgtgtcagtggcctgcagg ggaagtgagaaccgggctcatgctgggctcctctactttgcagggtttaaggccg 1881 2376766 SRGAP2 YES actacagcatgaaggaattttccgggtgtcaggatccca 1882 2648351 -- NO ggagcagcttcaatcaaaaggcggggctt 1883 2855376 FLJ32255 NO ccttttctgggggatcctaggcagaagcgatggcaggacaa 1884 3715585 -- NO aatcaccatgacaggcagagtgtgggca 1885 2432021 -- NO agtttagttctcttacgtgtggctagccaat 1886 2527209 RPL37A NO tttttataatgtgtctaggctgggt 1887 3753258 -- NO ttgagctgcccaagccacctagagg 1888 2607727 -- NO gctgtgcgaatggactcagctgcccgaactcacagaatatcagtaacagcaccgaaacttcaca 1889 2970557 HDAC2 YES gctgtcaattttccaatgagagatggtatagatgatgagtcatatgggcagatatttaagcct 1890 3233715 LOC399715 NO ccttctgcaaatggggatgagtcctc 1891 2555212 PUS10 YES catgctgcatggttgctggtaaaaca 1892 2601671 DOCK10 YES tatcctggtggagcagctatacatgtgtgtggagtttctctggaagtctgagcgatatgaactcattgctgat- gtcaacaagcccatcattgctgtctttgag 1893 3630677 CALML4 NO tgggcctgaaaacttggagcaattaattttttttaaaaagtgttcttttcacttgggagagatggcaaacaca- gtggcaagacaacattacccaactatagaaga gaggctaactagcaacaataatagatgatttcagccatggtatgagtagatcttta 1894 2677724 ARHGEF3 NO ggcgccatcagccacttttagaagccatcagccagtgtgttgggaaaagaggtttgtcaagtgttggcctatg- ggaaggtggtcaatgaatgttttga 1895 2898386 -- NO tggaggcatttaatggcgatgtgcaggtgcaag 1896 3412766 ARID2 NO catccacctcgaaagctgggcattaacgatattgaaggacagcgggtacttcagattgcagtgattttgagaa- atctttcctttgaggagggcaatgttaagct cttggcagctaatcgtacctgtc 1897 3975856 -- NO tggaatgtacctggaatagggaagtggacagtgagggc 1898 2466297 -- NO ccaggtcgcacatcagctgcaggcacagccagttcatgggtagacagccacatcctgccccaggaggagggca- gccagcatgggcgatgcaagctcc cctcgtctggaaccagcacaacctcaggcactcgagccttggcccctcacaagcaacgtcctcaatgggt- ggcgttcgttcat 1899 3240817 -- NO tccatcgattgactgcgaggggctagggttcacagcaagcagaacgtcctgggtttctcttcaataccacctc- ctcctctcctgttcagatgctgagaaacatc tggcgcagtagagatgctgcctctgacatttctatgacaaaacgcgtgcctgtgctagggtttgcacagg- cacaagttatcacaacctcgggatggggctg 1900 3454311 LASS5 YES catcacttggtcaccattgggcttatctccttctcctacatcaacaatatggttcgagtgggaactctgatca- tgtgtctaca 1901 2437092 DPM3 NO gggagtgggtctcaaatatagagggggtagcaaggtggaaggggcccttccaccttttgtgggcactcaagtt- cggacctctgggatcggcgattccc 1902 2683293 -- NO catctgtgcttgacgcagaggcctccggggtcgcgagcttcggaggtggaggtgccccgtcttcgggttccca- cgccgccctggcgacctggggctcca gccccaccgcggactccggtgggacgtgggtggcgcaagcacaccttgcccctgtgactcagcttgaggg- ggcccaagctgtcccactgagcacgcgc ccagcaggccgtcgcgctgcgggtcctggtcctcctgtcatttactggggtgcggaggcctccgaggagt- ctgagggtgggacagtcccacttccggag gagctagggcagggaacacaaagtcccgagtgccggggca 1903 3701415 -- NO ccataaaattcgcatggtgaaatgcacgtaacataaaatttaccatcttaaccatttaaatgcacagttcagt- ggtatcagatacattaata 1904 2590322 -- NO ctagaattaagatatgctgatgagttgcttctgcagttcat 1905 2973489 -- NO tttggcgtttgctacagaatggtgaatttatgtatttctcttccactttgacatggacattgcctcattcttc- agtagtgtgcatattcaccttaatttattcaaaagctat tttacctttttcaataacaccacatcaattaccttaacttattcacttacatcagtcttccc 1906 3020769 -- NO ggatgcaggactgagtcatgccact 1907 2807755 -- NO gagtagatgtaactaagaggtttgagaaaggaatttcagcagagttattgaaggagaagtcaaggagaggaga- aggagaggagcagtgaatgttgtcgtg aagaggtgttgtcttgaaatactg

1908 2918704 PRDM13 YES ctctggagtggatagggttaatccgggcagccagaaactcccag 1909 3024096 -- NO taacaatatgtgcaggcaggaccgaaaa 1910 3270274 -- NO gggcgctttcccactgttctagacgtaggagagaaagcacttctcagatggtgagcttttatcttccaatctt- gtcaaccgaggagacctggaagttccctttca acctggaatgtgagccctgcttgctgggcacgagataaggaccaaggattgacccaggacaatttcagag- agcacaggggtggcatatcctcatgtcagg gcgtggagctaatattcaga 1911 3356025 -- NO atggcccagaatgggttgtcagtgctccag 1912 3913713 YTHDF1 NO ggaccgttgagctcactaccacctggagtttgagttgaagcatgaaaatggtgcccatgcctgacgctccagc- gcctggatctgcacgtgcccttgtagagg atccttaccgtcctagagagcagacgctactgaaaactacttgctccaaaagaccctctgagttaacgat- cagctgtatcattagacttgtatttagagcgtgtc acttcctctgaactgtta 1913 3506761 -- NO tgtagtgttgctgtatcttccatcgtacagtggaatggcatcttacagaaggggtttcggtcctatggttagc- ttaatgttgaagtcagggaaagtcaaaatcacc attggaactcccttcaactgtctataaaatacactatgcacagtaccttggtttacgtatatttgcataa- atacatactttgtatagtcacatgttgtatgacaacttac tgagttgttcgatgaacaactctatgtgctaataataattttgatgtattaaaatgggaaagcatttgct- taactgagtggagaggcacaggttgctgagtcagac gtatctcctgttgcacacgtaccttcaggatgg 1914 3888725 PTPN1 YES gcagatcgacaagtccgggagctggg 1915 3357756 -- NO tctgtccagagtgcaaggccgaaccagaggacacacatgatcatttctattttagaaacacgcctggggcaga- gaggacagcaggtgaaagagactgag agagaacagtcagaggctagtactggccaagacaggagagtgagggagcaaccgtaatgaggatggatga- ataatttgagagagatttaggggtaacga accagactcactc 1916 2371244 -- NO atgagctcaccttgcctgcaactgtctct 1917 2660674 -- NO tgcccatttttctacggcttgttgatttcttgggagttccttgtaagctttatagtctctgtaattaatgagt- tccaaacatttttcctagtttgtcttttgtcttttgtttttgg tgtggtgtgtcaaacagaactgtttttttgttgttgttcttacatagtttaatttttaatgcttctgtat- tctaaatcatagccaaaaatgacgttcccatgcaaaggaat gtctcatgttttctttggatacttgctgtggtttcattacttttccgtggaaagctctgatccttgtgca- gttgatcctgatataa 1918 3199144 -- NO tagaatgtttgtatattgctgcctggc 1919 2411720 -- NO agatccaattagagccagggtcagg 1920 2682075 -- NO tgataatagggacgttgtcagacccttaactaagccacacactgctgggagcctccggaataactttaatgta- gttgtagggaagggagtcgaggcaggga tgaggatccctgcttgactgctctctttcctgacgaggaagaaaaggacagtgatcaagcacagggtctc- aaaggaggtctta 1921 2709855 -- NO ggacagcattacggtggacagtgaa 1922 3016026 MUC3B NO ctgcaaaacgggtacagcattcctgtatgatagctcacgccgtcgttgtgaaaaccacatagacttggtcaat- tctcggtcctactctgccctcccgtctcagc /// cctcgtgttgccattgc MUC3A 1923 3550736 LOC730217 NO accactacttcatgcagggcagtgtgcc 1924 3059100 -- NO ggaagctaccaaggagactattaaagaaattcaggatggtgaagacagcttaaagggaaacagttctgcaaat- agaggcgatgggagatataggaaaga gggactatgtgtaggtcttgttgcgtcgctgaag 1925 3379723 MRPL21 YES tggttggggcagacaacttcacgctgcttggcaagccact 1926 3432355 -- NO cgtcgtggatggatcagttttgctcgatagagggacatgtttttctgtggcaacaggagggcaaaaggagaag- gtggccacagatgccggtagatgagctg agagtgattgtattccctatcctctcggaagcttgaggcaaggccatcaacagacaatcagagggaataa- gaagagatagaatatatgaagaaagggaga aaagatgaaatcgtaattgtgtagcagggcaagaagtccagaaatttctgtgctgtgccaagttcccagt- tgaggcggtga 1927 3511352 -- NO ctgacggtttaagatgctgcattttaagtaatgctgagttgtatttttatttcagtcattcatttctacttat- tttgagcacccattatatgttaggttccatgctaggcac tgtaaagataaagatgagaaagactcagcccttacctaaaggagtatagagcctagttggggagacagga- ggcagatagttacagcatggagagcaaatt ctctgagggaggaatgaagtgagataagagcacagaagaaagacccggggatcagagcagacttcctgga- ggaggcaatcattgacttg 1928 2627501 -- NO tcctgcttgtgaacagattcctatttccgtgaggaggtgacctcgaagaagagcagcttctattctgctggga- ggtgtactgccttctggtatcaggcttctgca tcccgggaaagctcgggataacctgaggcacc 1929 3608077 -- NO agaccacaatgagggacatggcaagttcct 1930 2393810 -- NO ttgaggaaaattgctctgtccctat 1931 2506539 -- NO tccatttaaatgagagggtggagctgtccttgcaaaccaatgatgcagctgatgccatgcagtggatcttcct- tccccctaaa 1932 3068053 -- NO tttcccagagctctaccttgttgtcagcactccctgcaatag 1933 3762439 -- NO ctaagagagttactgaccctaactcccctaaaacctaactatcaaaagcctaccactgactggaagccttaca- ataacactaacagttgg 1934 3896232 -- NO tcagtctgcgatgaaggtgaacccatcttataaagcagagcttacttacattctgcaggattttggtgtggat- gcatagaaggcttacctggttagtaagcctcc attcctccgacctacagaaggcaacccttctgcagctccaagcagggatttctagaaaagaccaggtgta- caaaacatctaagctgtgcctcccaccacag gtggggaagtcccctgatttggtcagacacagatgaatgtctgtgtctgactgagcccagaaacagttca- attgatgggggctggaaccaccaagaaaaca ctcctgacctgggcaacactgtcttccagattat 1935 3916144 C21orf74 NO tgtgtgtacctgagataagatgatgtcttgtccaatgctggtttccaccttgtgccctgagctgttgggagag- gctcctgcgacctgtgac 1936 2389578 -- NO ggcttacgcagcagatgcacgttcagcattgagaacccggtccgacaggaaagacacaccatttttccgccag- aaactccagtgttcaaaatacaaactgc caacttttcaggcaataatcatgagcttccattagaaaaagccatcagctcaccagacgacgaaatatgc- tctcgggattaagaactttctcatcctccctgag ccctttcctttcaggggaagtgcaagtttg 1937 3290995 ANK3 YES agcgggctaacaccactgcatgtagctgcacattacgataatcagaaagtggcccttctgcttttggaccaag- gagcctcacctcacgcagccgcaaa 1938 3403153 EMG1 NO tgtcacatcctttgaccctggtctgagctgactgctggaagatgatctttctgcactgagactgtggagtttg- gggaagccaaggctgtacatttgctatttgttta tcctatgaatactgttcttgcaaacctggttgttttggggttcctaaagtatccagtggtgtaaaactgt- ttgttccccgggacttcagggacagataggaggtta cagagtttgcagtttggttccatgctttgaaggcaggctttagctcccagattcccatgtgctaaaggag- agaaccctgatgatggagaagaactgtgaaaga gagcagtcaggaatgctagtggtgaaaaactgaacaaacagaagtgattttatctaatacagttccaagg- tagaaaaagtggagcaggcagggccttgcac ccctctccacccccccatggggggggtggtggtagcggcacatacacaatc 1939 3439875 -- NO acctggctttggttattgatgagaagagtaattaatagaacattccctttgctgtgataccctacccaaaata- gctcggttgttggttcactttcttcagatacctcc ttgtctcatggaccgcctacttact 1940 3568358 -- NO tcatgggtttccaaatatgggatgcaatttcaagttcttaacaccaaatataaccctacttgttttagtttcc- tggcattcatcctatcatccccagtttactgcacctc aggttatcaaggatgtgggagggattctacaagggtatgttcccccagagctttttggtaccctgcaatc- ccagaagttgttgatgctaggatgtctggagagc actggccatttattactga 1941 3701322 CDYL2 YES tgacgtgaatcacgctacactggcggagaacgggctc 1942 2975832 -- NO gccatgatcgtagcactatactctagcc 1943 3072788 -- NO gtctaattcagaacccggtgggctctccatgcattattggcagcacttttatccaggggcacagacagggaat- agggttactggaaacagggagtgtagctc aaggaattgttctctctctggagtggataagttgtttgacctactgactcatttcataggaattaggaaa- acaacctagtgtggtttttattgttagtcctggaggat tccaaaatctgtgtgcctgcaaataagatgagctggggaaagggagcaccagcatttggtgtttctactt- gcctcttttcctgatggaatccaatcctctgcttc 1944 3380982 -- NO gctgtttcagtccacaccttgttcacagtaagatattcaattcaattcagcaaacatttgttgagtgcttgct- gctctgtgcctgaccagaagaaatgaagccaag atacaaataatagaaccctgtcatgagcacagaaagacctgctgagtttctattgattgtggtaaaccag- cctgcatccagttccaagtaacagctgcccactt agtgaatactctctcatgtttcaacactcagttctagtgtagcctcttctataaagcctttcttttccag- ataaaattggttaatgtgtcctgtgttaggctgattgatttt gatgatccctattcatggtctcccctgtatccatctctttttgcctataacattgtagtcccatctcact- ctgatgctgggaccagacatgtgacttgttttagccaat gagatgtcgataaacatgaagcaaacagaagctttaaaggaggcctgccctcttgctctttgccagtgcc- atgagaacatggctgatcagctggagggttat gagatgtgtaggtgagagacatgcaaaagagccagagataccagctgaagccatcctagactagcccaca- gtcagcctacccccagtcaagatcaggag agtcacccaacccacagatgactgccgacacatgagtaagcc 1945 3902033 -- NO attccacgcgtcaaattgtgggcagtga 1946 3952107 -- NO acaggcacaggggagtcaagcttag 1947 2678585 -- NO agcacccagtctctgttctcagagg 1948 3463862 PPFIA2 YES tctcaggggatcacgagtggaatagaactcaacagattggagtactaagcagccacccttttgaaagtgacac- tgaaatgtctgatattgatgatgatgacag agaaacaatttttagctcaatggatcttctctccaagtggtcattccgatgcccagacgcta 1949 3727958 -- NO caccatcttctcggatggatggcaaag 1950 3974043 -- NO agcaagccagtgcagtccttggtcacagtcactcacag 1951 3982214 -- NO ccaaaaccaatgtgtctaaggtgcggcatcttg 1952 2685843 -- NO gcggtggtccaatcatagttcactat 1953 2686522 ABI3BP NO ccagacatgccaccaactaaatccg 1954 4014220 POF1B NO cttcctctgtagctgccagacctgc 1955 2838069 TTC1 YES aatggccatcaatgactgcagcaaag 1956 3701416 -- NO cgcatctggcctataccagtgtatgttttctttaggaaaaaataaggcagaaaccagaaaactaacacttcac- ataaatgtaggtgcagaatattggtacgatat tggataacttaaattgctgaactgtatgaaacttaatttttctaaggcaaaaattgatatcattggaagg- atcttggagtcagtggcaggcaaacaaaatttaaac ttggctgcattttcttttttcgtttcaaatgaatacttaactaggtgcaatggctttatttgtggtcttc 1957 3756107 -- NO tgaattcacagtgttgtatcccatgtagggaaaaataagactaattttccccccacactctaacacactgtaa- ttttgcacttggaactttgctaatctactgtccaa cctccttctcaacaaagtcaaatcaaaggagaattaacctagaagaggggacaataaaataagaggtcct- cagggagagggagaaccaaggaaatagaa tctacttaaatctggccagatagcacctcgtggatt 1958 2382147 CAPN2 YES atgacaggctgcccaccaaggacggggagctgctctttgtgcattcagccgaagggagcgagttct 1959 2590022 ZNF385B NO agagaaacacatcactagattgacgagggcttttagagactgctcctataattgaggaatcagcagcataggc- tttatctccctacttc 1960 3831701 -- NO gtattggcgactgcctgtgcatacac 1961 2792492 -- NO ctgactgtgaattagagtttgcgctattggaaggtggaacccactgtgctcattgtata 1962 3289301 -- NO gcatttactagtgctgtgtgcctcgttgcttttctgggtagtgtttggtgatgggcatagtgtggagtggtgg- tagagtacacagtgtgattctgtctggtaagga agctgtatgttgatgttcactgatgtgaataggttcatacagtcccttaggcatttggctggaggataaa- gaacagccattgaccagcagagtactttttttgaag tttatgcaagacagcgtgctaggtactactgccagcttga 1963 3686344 XPO6 YES gtcctttctccagcccgacatccacctttttaaacaaaatctcttctacttggagactctcaacaccaagcag- a 1964 2596800 -- NO tgactaaaattttgggtctgggctgttatatcactttgtgttaagttatttgtagtagctaatgtgctaactt- atatatgtgttctttctgattttttggattttaccttttgatttt ggcataacttatctatatttttgtttacattattttaaaaatatcagtaactgtaataatataaaattga-

agttgtattgagttgacaatacctctagtttttaaggtcatctgt cacataatttaagtgcaccagttcctaatgtataaag 1965 2614940 -- NO ctgctccattggagacttcctgagggcaacagacaaactatttgatagctgaat 1966 3988991 NDUFA1 YES tcattttgggtatcactggagtctgatggaaagagataggcgcatctctggagttgatcgttactatgtgtca- aag 1967 3068834 -- NO tcatataatagacagtgcggttgcaccttgtgttcatgtactgatagctgttaagggtgcagtgatgaaccaa- cagagctc 1968 3116499 -- NO gcctctctgttctcatgggctacatg 1969 3227229 FNBP1 YES ccaacctgaacgaaatgaatgattacgcagggcagcatgaagttatctccgagaacatggcatcacagatcat- tgtggacttggcacgctatgttcaggaa 1970 3777767 -- NO tgtgtttggggtgattagagcttcttgcaagcttagaagtaggaagctaatg 1971 3950135 -- NO cactggcacaggacgaccctgaagg 1972 3425446 -- NO gcatgtcttgctactacttcatagatgtcataagacccgtttatggattagagttggtgtagaaagccattgc- cttgagttgaaaaatgaatactgtaaaagctca atacaaatcctccaaagcacatgcactt 1973 2359042 -- NO ccaagttctcatcttcagcatcgcagtttcgttctccacc 1974 2437704 GON4L NO ttccattctattactcttaggtttgtatctcatggaattcactttaacctctgcctcgtgttatttgctttag- ctgtacattatgctctta 1975 2778373 -- NO cccaaaacatagatccgaacaccagctttgccc 1976 2954503 -- NO atttcctacactgttgatggtggcaatgacaaaatcaattgcagtg 1977 2441001 -- NO ctggagaaatggctatgggtgactg 1978 3162378 -- NO gaattagttcctcagcccagtgtaagactggattaaaaatcgtgcatggatgtgcaggg 1979 3199012 MPDZ YES cacccagtcagtcagagtcagagccagagaaggctccattgtgcag 1980 3449682 -- NO aagggtgtggcacattgctggtgttttcagggaagaaagcagaacgtctgtgggcaagcagtgg 1981 3687337 -- NO ggagatccttgtgtagcggcagaaagtttagcaacactgtctcctgcattagtgtggagggtaggaaatatac- ctaaggaacggatggtctagctaaggagc tttccagacagaatgttgaaggtgccacctggcttcttgctgcttatagtaaaactgaagaggagagagt- aagttaaagaaaaaaaacacttaaatgaaaaag agcctgaaattgttgggtttgaaaattcccagcctttccagataacaagtgatgttaaaattaacaaatg- gcttccgtgcaaagattaaatacaaggcattaaata cagggaaatgtggtctaaaggtcaagctgaggatgtgatgaaaaagtcctttgttaagacctcagaaata- ccaacaagatgcctcagaggggacttccagtc gaatgaaataataatcacgcttctgagaaggttaaaggtgttgtctttcagcgtctcagcacaagcccaa- agtagagaagggcttaccttgcagagattttc 1982 2333554 ST3GAL3 YES cctacccttggcagtgtggcagtga 1983 2570354 -- NO gtgttacttccaccatggtgccacacacttaatatccattcc 1984 2873144 -- NO ggggcttctctatgcccggaaactgcctcatcaactgaaacaaatcctgaatcatcaaagggccaaacccact- gccacctttagacggagcaggagagtta ccctggctctgtcactgccactaagtcta 1985 3409485 -- NO tgaataggcagctagtacatgaacctggcattaggggtttggggctggcatacttaaacatgtggctagatgt- gatcaccttcagagtaaatgtaaatagtatc atccctccttatctgtatc 1986 3476542 -- NO gtgtgttccaggcgatggcaggaggga 1987 3620299 -- NO atgacagtttttctctaggctaataactcaatgagcagaaaggaaagtcctcccttttaaatgtatatgaatg- tatatgtagttcacacttacactctgacacagat ctcattgtgtccaatgatgtgtgtgtgtgtgtgtgtgtgtgtgtctccaagactgagacacatgtactaa- agagtgatactggccacatctactctgggcttggag ggtaacttcagcaa 1988 3626913 -- NO tgcaacctcgacctgcttggcttaagcaa 1989 2699759 -- NO ccatcatgagctgaccaacaatttctaaattcctactcagaaacacagcaaggggaatgcagtcaagcacaaa- gggcttaaatgaccagataaggctgggc tggatgaataaagaggaatatcctatgaatgtgactgtgtagttttagagtatcccgattcaactgttat- atttgacttgtggccttgtagacagtgtgtta 1990 2737582 -- NO tagccaagtgcagagggtgtctccgggtgtgtgcgtggcccacaagagggcaagaagagagaaggcggggata- ggagggaagagggtgggggtga gaggcagccctgagagggcggaggaaggaagaggctgggagctcggcgcccgcggcgcagctgccgtcgc- tgccgcagctgtccagggaggatcg ccaaaacggcgacgaataaacaacttaccttgcggagaagagctacgactgcgatgc 1991 2964449 MDN1 YES cccgatggaatatgcaggctctggacatgattagaaatttgatggactttgacccacaaacggaccagcctga 1992 3695220 DYNC1LI2 YES ggagctgccttgatttacacatcag 1993 2939888 LYRM4 YES taaagaatatctcctccaggtgtggt 1994 3632627 -- NO atggagatctacactgacaccctcagtcctagaggcagagaagaggttcagatctggcctg 1995 3695228 DYNC1LI2 YES cacgcgctgcaacgtgtggattctggatggagacttgtaccacaaaggcctgctgaaatttgcagtttctgct- gaatccttgccagagaccctcgtcatttttgt tgcag 1996 3854016 -- NO tagatctcgtcgctggtatgcttggttccgctcctcgtttcttagttgcttattctacccgttattcactgat- gtta 1997 3980369 FAM155B NO tccatcacagacagcagagccgggcagctttcttatgccattttctacactgtgcttcatgagtaggactttc- ttgcactagttcctatgactgagtctccaaact ggtttcctagtagtcccccatcccttcctcccttacccagctatgattcagttgtctctgccctccctct- taccctgcctctgtgtttcggtgagagtc 1998 3799919 -- NO tgtattacacagagactaccgcacaaaacacggacccaatgccaggcaagcacgcgcccagcctgaacctcca- agaactgtctt 1999 3032425 -- NO cacacctgtaagctgaggtgaaggagtt 2000 2475245 PPP1CB YES aaagaaagctaaataccagtatggtggactgaattctggacgtcctgtcactccacctcgaacagctaatccg- ccgaagaaaa 2001 3487169 DGKH YES tctggggataccgaaagtgggtcatgtgaagcgaattctccag 2002 3955155 -- NO aatgacatcccttttgagctgtggatggtg 2003 2827160 PHAX YES cacggcaactgcatgtgcaccagtatcacattatcgagctgttgaaagtgtggattcaagtgaagaaagtttt- tctgattcagatgatgatagctgtctttggaa acgcaaacgacagaaatgttttaaccctcctcccaaaccagagccttttcagtttggccagagcagtcag- aaaccacctgttgctggaggaaagaagattaa caacatatggggtgctgtgctgcaggaacagaatcaagatgcagtggccactgaacttggtatcttggga- atggagggcactattgacagaagcagacaat ccgagacctacaatta 2004 3186892 -- NO atagataacgtttgtgtggcactccccaagactcaggcattgtgataactaacactttccatgaataatgtca- tagaattctcacaaacatcctgtgagatagac actattattttcaaccccatgtacatatgagaatactgagagttggagagactgagtaacatgccctaga- tgactcagctagcaaggaatgaaaagcacattct aactccacccacatatatagttccaggatcccatctctctacctcacattaattagttctataccagctt- tatgtttcctactagaatgtgcatgttttaaaggctgag ctttc 2005 3195536 -- NO tggccttctggacagtaggtaggcatgtgatcactgttgtcactaaacctgggaaatgattcctgggtcaggg- ttcattaattgc 2006 3238305 -- NO gtattgaaattcctcgagccgctgcttttctcactccataattctggccagaatttggtacttaaaatatttt- gtctaaaatattacaatagctacttaagtcatctccc tgactccactctgttgtctttcagggcgtcgtccacactgtagccaaagtgatcttataaaaacataatt- ctaatcatggcactcttctgcttaaaaatgttttaatg gctttccgttaggttaaaatttaaaagtcctttgtagcctgtgaga 2007 3744218 VAMP2 NO acttgctggaaaacggggatgcttgcccctctccaggactattgagcccagagagagctgtcctctcattggg- tgaactgattgaggaagggtctattgtcttt ttaaatggcacaattttaagggtttgagggtacagtcccttaacctgccacgggagggggcccccaaact- ttcttccccccacacttctggttttctgtgtggag ggggagcagggatatctaagctgtggtgtgaaagggtaggagagatgctggaggtgggggtgctgtgttt- tagaccccccatattatcccagtgtcccctg cccccctcttcccccaccccatgcccccaattctgtggcgcatccagattgtgaaaatgta 2008 3810033 -- NO gtgaatatatctaggtccagcagggtctcagaagcagatgccaacctgaggggaatatttaccagatga 2009 3943786 -- NO cagcagctgctatccatcgtcatcaccagtgtcatcatcgccatccccatcatcaccaccaacaccgccaccc- ccccagcgacacactagctgtggacaca tcctttacgcccttgaacctgagtttctacagctatgaagcaagtcccatggaatttacagaccaaacgc- taagtgtagggctccctgggagctggtcttatgg agcacactggca 2010 2321472 -- NO cagtccatgaggtccacttgtctaaatatgtcacttgaagtgcaaggtaccaattgctcagtggctcaaaatg- attttctggttctgttgtcatttcaagagcttctc ttgagggttgagagagtctgttttcctaagaatctggttctctccatcagtctctgtttccaccttatct- tcctgggaaggtgtgctttctttgaggtgagatgtgaa gcctgcccacgtgcagttttatgtcgaattccaagtcagatcttaacttggtactcccggagcctgttgg- aagtctta 2011 2361272 -- NO gtgcaacatcactttgacttgattattcttgggtctgttttatttcccgcttttattttgcttttgaaatctt- tttccttggtggatttgtacgtgtcttcactagatgcctca aattaagtctgaccacaatcctactctactt 2012 2447714 -- NO tgccaacttctcttcaccacacaatctgcagaagc 2013 3175671 VPS13A YES tatgatgatgcctatagatttgggggaaaagacaatatatttagtttcattctttgaaggtttacaacgcatt- attttattcactgaagatccaagggtatttaaagta acatatgaaagtgagaaagcagagttagcagagcaagaaattgcagtggcattacaagatgttggaattt- ctcttgtcaacaattacacgaagcaagaagta gcctatata 2014 3517776 -- NO tataaggacttcacagatagctgccgtggatgctg 2015 3626941 -- NO taatttcacaatgggtgtgggaggttggtgagtagatggactagattcaaaagtagatacctcgctctcacct- atagcctagcagttt 2016 2467805 TTC15 NO ctccaacacactacgtcagaaggacccgg 2017 3701421 -- NO ttgctttgtcttgtgatcgcagctcacggcagccttggactcgtgggcacgag 2018 3717066 NF1 YES cagaaagtgctgcaattgcctgtgtca 2019 2476534 -- NO agatggtacaaaggtcgtgatagggctg 2020 2750682 -- NO ccaagattaggccactgccctgtaac 2021 2412205 -- NO gggttaagctgggaaccatgtctcctggggcaaaattttaattcttctagccacttgttatgtgatctcaagc- aaggtacatacgtctctgggtctttttttctttatct aaaatatgaagagattaagtgttttcttaattttctttcagctctgatattatgtgattctgtgattaaa- tgacctggatgttgataatacatgcc 2022 3019902 -- NO ctttggagttttcgcccagatcagaattttattgccttttgccgtagactgctgcaagatttccagagcaaag- agaaggtatagtgttccttaatgtgagttatgaa gatcaaaatacagcaaagagaagatttcagagatttaaaagtgataatttttactgaaatttggaaatat- gtctccatattttaactttattttataaaaaagaattact ctgttttttgaaatggccaagcattaagtaatatatgaccgtgaatttcttgagggtgggaaatgtgact- ggattttatatttcgattgtatcacatgcagcctc 2023 3750928 KIAA0100 YES acactatgtggcattgtgctttggagaagtgcgtatcagaacggacctacagaaagtttctgacctgtctgcc- ccattc 2024 2511032 -- NO atgactgagtcttatagcggtgttgggcatagca 2025 2568632 -- NO atcctttgtcccgattgggtcccagatacacaaaa 2026 3039827 -- NO gagtccttcctggatagcagcaccaaag 2027 2437284 C1orf2 YES cagctgccaccggttggagggctgg 2028 3076362 -- NO

gcatacaagtctgcccagtcccaggaagaaagaggagagaccctgaattctgaccttttgatggtcaggcatg- atggaaagaaactgctgctacagcttgg gagatttgctatggaaagtctgccagtcaactttgcccttctaaccaccagatcaatttgtggctgatca- tctgatggggcagtttcaatcaccaagcatcgttct ctttcctgttctggaattttgttttggagctctttcccctagtgaccaccagttagtttctgagggatgg- aacaaaaatgcagcttgccctttctatgtggtgcgtgtt caggccttgacagattttatcaaaaggaaactattttatttaaatggaggctgagtggtgagtagatgtg- tcttggtatggaggaaaagggcatgctgcatcttc ttcctgacctccggggtctctggccttttgtttccttgctcactgaggggtctgtctaaccaagcaggct- a 2029 3527927 FLJ10357 NO tgagtcagcatccccaatttctaccacatccagcactcctaccatcttgcatgtaccttccttcctgtccccg- gctacttgggagtcagcttcttccctctcccaac tcatctccctcttct 2030 3889598 -- NO caggtcttagcggtcatcaggatgaaggcggtgggaagtggagcaacagagatccaaatatggaaagagcacg- tgctgataccagaggcactggaaata atagcaatatccgaaagtctgctcaccctgcgtcattccttcagacagtagtcgggctctattc 2031 3735624 MFSD11 NO ttaaaatctgcaatactggccaatattcttttatcaaacaggagaccgcagctttaaagggggaaaatgcaga- cgttggataaaaacagcaagaaatagtcat tttcattaataggtctcaaacagtttacgaaacagccattattatc 2032 2739508 -- NO ggcatgtgtgggtaattagttctcactatggttagactcctgaagtgagtggtccaagttgttagcgtgcttc- tgctctgtgaggccaggccagtatcctgtctg 2033 3819517 RAB11B YES gacatcgccaagcacctgacctatgagaacgtggagcgctggctgaaggagctgcgggaccacgcagacagca- acatc 2034 3330082 PTPRJ NO ggggtcagctatgcagcccatcacgtgtgtttttcatctgggatgaaaaagcctggttctcttttgaaatgct- tgattgtacttattgagctaaacaagtcttggtg actgttgttgatttgcctcaaaagttttaagtcctgggttttcagactactgtgta 2035 3378442 SPTBN2 NO ggccacattctcctaatagcatgaaacagtcagctcactttctgcctcctcctcttacacttccctgctgtcc- actgcggccaactcagcacagtgtccttgaag ctgattgagggtc 2036 2473789 -- NO gcgcgggctttcgagcacatacaaacctgattacaaaagtcagatttctttatttcgtcttgggcacgtcatt- ttaaccccgctcagcctctcttttgtgtatgaaa ctgaaagtaatagcttctgctgtgcaaaatgattagaggaatttgtgaagcgcttggcaacatactagga- ccc 2037 3115627 -- NO ttgagatttatgtgtgtgccagacacacacacacacacatatgtacacaagcaatttttgtgtgtgtggctca- agccaggcagagaaagacaaatactaaatg atctcactcatatgtgaaatctaaaaaagttgatctcaaagaagtagaaaggagcctggtggttatcaga- gtctggggagggggttggggagatattggcca aaggatatacaatttcagttaggtaggaggaataagttcaagaagtcgattttgactatagttaataatg- tgttgtattcatgaacaaggctaagagagtggatgt aaagtgttcttaccacaaaaaggataactacatgaggtaatgcacatgttaattagctagatttagtaat- tccataatgtatccactg 2038 2745189 -- NO tccatttctttttactgcgtccgtccctgacaatacctgctgtttactcagcccttaacgttg 2039 3450260 -- NO aaagtgatacatttgtgagggaggagg 2040 2656876 -- NO cagaccttatctcatagggtgattatgagcattagatgaaatcgtgggtgaaaggctcagtacagtgccaggt- atacaagaagcattcagttaagtaatagct gttattgttataactgaggttttcacaagccgcacact 2041 2952697 -- NO gctagtttcaaagactgcgaccctgttttgaattggcttgtttatgttgcgacggtggctggaagccaggcca- acccagggtcagctttcccaaatcagtcgcc aaggcccacgagaacagtagtttcagaactcccagaaataggttcaaagatgcctgtcctgtaccagtcc- tgcccagcctcgtttttccttaccaccctgactg cagtcttaactcctgcaaactaatttgatcgctctaagtttaaccgcgcccagaatttcacttttgcttg- cttggcctttgctgtgggtcacaacagcccttcttgc 2042 3579549 WARS YES cctggcctctgtaagcctgtgtatgttatcaatactgtttcttcctgtgagttccattatttctatctcttat- gggcaaagcattgtgggtaattggtgctggctaacat tgcatggtcggatagagaagtccagctgtgagtctctccccaaagcagccccacagtggagcctttggct- ggaagtccatgggccaccctgttcttgtccat ggaggactccgagggttccaagtatactcttaagacccactctgtttaaaaatatatattctatgtatgc- gtatatggaattgaaatgtcattattgtaacctagaa agtgctttgaaatattgatgtggggaggtttattgagcacaagatgtatttcagcccatgccccctccca- aaaagaaattgataagtaaaagcttcgttatacatt tgactaagaaatcacccagctttaaagctgcttttaacaatgaagattgaacagagttcagcaattttga- ttaaattaagacttgggggtgaaactttccagtttac tgaactccagaccatgcatgtagtccactccagaaatcatgctcgcttcccttggcacaccagtgttctc- ctgccaaatgaccctagaccctctgtcctgcaga gtcagggtggcttttcccctgactgtgtccgatgccaaggagtcctggcctccgcagatgcttcattttg- acccttggctgcagtggaagtcagcacagagca gtgccctggctgtgtccctggacgggtggacttagctagggagaaagtcgaggcagcagccctcgaggcc- ctcacagatgtctaggcaggcctca 2043 3703035 -- NO cgatggacactgatgcccacacaggtg 2044 2444562 RC3H1 NO tccagatggatcgttggcctaaattttcacacttctccctgttcatcctttttcctcttccctgcttcctggg- aataaaaggaacttttttaaaaaaattaattagtcc acaggtctcattatctttctttatgattaatctatgactttttggtacaagaacaatggaaaaagtgaat- taaggtaatgaacaaaacctttcacccacttaaacattt tccagttttgagattcctcttcgtgtttgtggtgtcttccccttgttaccccttctgccctttttctctg- actatggtaatttggtctttaggctcatatcagtctccccga gacattctgcagtcattatcacctttttgggtggattttattttgttttattttgttttttttaaaaaaa- taactttttaacattggtgcatatttgcttgggatagagcttgtg taatttaccaatcgtattgattgtaagtgattgtgccctgcagaggtatatttaacaagacaaaaataat- cttggttaataaaggagcccatgagatttgagtcag gttgtaagtgaaatcacttacacttttggatagaatttatactcctgctcttataaatcagtggtagact- taccattttttaaagttttcttgcatttttttgtttttttattgc cacagctccctattctttcttgcctgcctccacccccctgttcaggaaaaaaaaaaattgagccttaaag- tgacagctgattttttaattgctgaattttgtgaaattt tactttttccaagtgtttccaactttaaaaagagaagtgaagacaaataggttggaatggtgaagacaaa- tggattggaatttcacaggctgtgaataattcctta ggatctggcaaaccgtgaagtcttatttgaagaccttatctcctgagagttcttttggagtaggaaaaag- aaccctatttgaaatagaccgtttttctcttgtttttaa tctgtttaatatttctgatttttaagcagcttt 2045 3816284 DOT1L YES ccaggtcgtgctccaggttgctgctgccaccaactgcaaacatcactatggcgtcgagaaagcagacatcccg- gccaagtatgcgga 2046 3231694 -- NO atccaccaagcagtgcgtccaggtg 2047 3760111 -- NO gaatgaacgcagagagtgtcagtgctgaca 2048 3960937 -- NO caggcacaccgccttgaggtgggcagtgccc 2049 2519659 COL3A1 NO gaaagattcattggcatgccacaggggattctcctcc 2050 3380965 -- NO tctaacccttgagacactgccaacatccctcctagtacaagacttttcttggtgcttgctgtttttagaggag- ttttggcccttcagtgtttgtaaagctctcggatc ctcagaaaaaaattctttagtgattaattttgaaattggagctgtttgattattttgattaagaagctga- ttttcggcctggcacg 2051 3690096 DNAJA2 YES agatgggaatgatttgcacatgacatataaaataggacttgttgaagctctatgtggatttcagttcacattt- aagcaccttgatggacgtcagattgtggtgaaa taccc 2052 3777917 -- YES aggatcctgccgaaaggtgctcagtggcct 2053 3811929 -- NO atgtatcattctccatacacctgtgcctt 2054 2436400 -- NO ccagccacgcgtccagcaggtcagggatt 2055 3868616 SHANK1 YES tacatcattaaggagaagacagtcttgctgcagaagaaggacagtgaggggtttgg 2056 2833315 -- NO atcttttgattgctagcccagctgctttccttgttatcactttgtggagcaggctggacattgacaatgagtt- ctgagactgagtggaatgggagacccctccca gctggtggtcgagctgcctagagcatggtccatctgtttgggactagggttgagctcc 2057 2886091 -- NO tgacgaatttcgtctttcttccctacggtggagtcagtgttaaacatacaacaaggagttctggggcacaggc 2058 3146585 RNF19A YES atgtccacgatgtgctgcttatataataaagatgaatgatgggagctgcaatcacatgacatgtgc 2059 3271059 -- NO gtgagatacttgacatggggacctttac 2060 3589673 -- NO ttcaagaagttctggggacagaggg 2061 3971336 MBTPS2 YES tccttggaaaaacgctgatgcagactttggcacaaatgatggctgactctccctcttcttattcttcctcctc- ttcttcctcttcctcctcttcttcctcttcctcttcttc atcttcttcctcttcctcgcttcacaatgaacaggtgttacaagttgtg 2062 3304025 -- NO gtatgtgataagtatttggatttgagagtagacctttcatagtgaggcttatcaggttgaggggaggtgatga- ctggaaatatatttatttattttaaatcccactttg gctttagtaaaatctgaatatgtgtgcatttctagtttcttacaccaaatgtaggttccgtaagttcatg- caagtacagtgggtc 2063 3350758 PAFAH1B2 YES agacaaagagcctgatgtactgttcgtgggagactccatggtgcagttaatgcagcaat 2064 3921733 -- NO cagtgtcgctacaggggatctctcaggctcacaacgggccactcctctagggaagttctggtctcatcatgat- ccttgtttggtctcactccccatgtccttctct gtccctcctccaactgccatttatttatttaactgaaaaagtaccaatcacccacataggcatga 2065 2361637 -- NO acaggagccaatgcccaatcatagc 2066 2625412 -- NO accacctgggtattgaagccctataaaaacactttctacttaccttaatatagtctggcgttgctgggacctc- acagtgttctttcacactttttatgtaacttagga actgaaataccactcatgcatttgttctaaag 2067 2737704 -- NO gattgctatggaagtactgagtccctgaaggagagacaaggtgcaggaagccccaatcgccaggccatcgatg- aaattgtggagggcatcgcagagcgt tatcatccaggcaatcgtccctatt 2068 2795252 -- NO gttcggatgatttcacgggagcagc 2069 3203541 AQP7 YES gctgtgacctttgctaactgtgcgctgggccgcg 2070 3510917 -- NO aagaccagggtaatcatagaactgccaagcagaaagaaatgtagaatgtagcagtggtgtggagacccgtggc- tgacaggtggtggtcttcatataggct gagggacaggctagatgcatgtcaagtggc 2071 3670551 -- NO gagctccagggatatctcttctgcacattcttccagagcagtgcatctctcttctggttgtttgtacaccctt- cttttactctccttattatcctctcccatgttcattca gtacatacttagtgagtgttcaccagatgcttagcacctggggtatac 2072 3729159 DHX40 NO gcctatggcaggattctttcttgaattaatattaatccttaaattgatttttctgggattatacaaattcctt- tttatataaaagtatattgtttaaaacagtagctatagc cattaaccaaaggacagatgatatatatatatatgatatatatatatatataagttcttttttagctgta- cctacgtacttatatcagcaccatgtatgtaggtgtgata gtactttcaaacagcgcctccacctggcctactctgttatttccacctgtttgggtagggccatttaact- tccattatgccaaacttgggatgggattttcgaagca gacaacactatttcatcgtgtttcaaattggaaccttgaggctagttagtatcacact 2073 2969482 CDC2L6 YES tgtatttgccggctgccagattccataccccaaacgagaattccttaatgaagat 2074 3040116 SNX13 YES tggcaaccttattttactacacgcattgtagatgactttggcacacacttacgagtattcagaaaggctcaac- a 2075 3819122 LOC100129391 YES gaggtggctagaaaacggcaagaac 2076 2359763 -- NO acctgcgtcacaccctggctagtgacccagtcagacgtgctggggaccctggctgaccacctgtaccaggggc- aaggaaggaaggagaggggagcatt gtgaagcagggcaggatgactcttgaaggtggagacaggccctggacagctctgggacccttaatggtgg- cagc 2077 2969302 WASF1 YES ggtttgatagaaaatcgccctcagtcaccagctacaggcagaacacctgtgtttgt 2078 2330410 C1orf113 NO gaagctggtcccacggaaagtggtatctcgggaatcag 2079 3265461 FAM160B1 NO tctaggtggggaactgactgataacccttggcagcaatcaaagtgccagtggctcctcgatgtttacattttt- ttctattttgttcagtcttttgttttaaatgattcta aagagattaaagaaaacagagttttaaatgtcctatttacatgttaaaggatttggggaaattgggtatg- tatgtgaatgggtgtacatgtaggaacctgtagttc agcaaagctgcgctgggcacagcatgcttgtacttgattgacaaaatcgtgtttgccagtccactttcta- tttttcctttaagtgatgctgatcactcaaataatgct tttaagctattgtttgtttttatttgacatgttaagccgcagcactttcttcttcatctttccatttact- gatatttgggggaacaggctatcaaaggttccggcttgaag ggaactgtcactac

2080 3735093 LOC643008 NO gccaccgacttcgtgcaggagatgcgc 2081 2402500 PAFAH2 YES ggcaacattgacatgagccgtgtggctgtgatgggacattcatttggaggggccacagctatt 2082 3552152 MEG3 YES tcttcaacccactgcttcctgactcgctctactccgtggaagcacgctcaca 2083 2736402 -- NO attataaggtatgatatggcttcccaattgtcaaagaattaaaatgctcattaggagaggagtgactgcttct- ccctttagtagaaaaacaattcaaactcaggtt accaattacaatacacaaactaaaacagttatgttgagccgggaaaccgtcttcttgtaggctatcttct- agcaccaaataatgcccacatgatttctggctgaa ggcca 2084 2751960 -- NO gcttccttcgtgaattctaaccgtaccgttactgtgtttgaggatcactggcagccgagctctgagtggggaa- ctgagataagaaaggtgttgtcatgataaca cctggacagctgcatcccacagactatgggagtgccaggaaactggctacctcacagcagagtagagaaa- atggaaataaacacaaatataagcttttcag tgagctgtgggtcagagaaggccacaagtggtctggcagatcatggtgcagctctttgtttcatgagcta- cgtgcagcagtagtttttatgagctctttttgtag ctttccagccctaggattcagccatggtaa 2085 3024231 -- NO tgcccagaaacgaccattttggacaatctcatccagttttacgcttgttttattcagaaagagaatcacctat- cctcttcacatc 2086 2928814 -- NO taaggaaattgggttgtcaccactggctttgagtaattcgttttgtctatgcaagctgtcttcatacgaaaaa- ggttttcatactatatccagtccc 2087 3166955 NFX1 YES gttgaagtcgaaacatcccactggacat 2088 3829651 KIAA0355 YES cctgactgtggtgcaagtccatttccagtttttgactcatgcgttacagaaggtccagccggtggctcactct- tgctttgctgaggtcatcgtgcc 2089 3709186 JMJD3 YES gtcaggcagctgtaagcggcgacagaag 2090 2947628 -- NO ctgttgacttcagagtcgagtgtgag 2091 3820638 SLC44A2 NO cccagtgatggccacgtcttgtttctagaatcccttcctttgcacaagccatattctgaactcttaattcctt- cccttaacttcaatccctatgtctcctgtcctacctc atggttttcctggccccacacctgatgctcagagcccactgtgaacccctggtgcctcttttggactcgg- ttc 2092 3823661 AP1M1 NO cagcctcagactttttcccactgagggtccagagagcggggccacgtgtcacccacgtctgcgcttggtcacc- cgtcctccccaccctgtgtgtgtttatgtc atagttacattaa 2093 4038647 -- NO aggtctccgctttcctggaaatccagaccc 2094 2543897 -- NO agctctgggtgagacttgtcttccgggggctg 2095 2353902 -- NO ctctgattaggtcttgtgcccattgttgaaccaaatgctgtgcttaggaggatgggacatgttctttttgttt- tgcttagttagggcctggctctggagccaggaga ggggaggaggaaatgttgctggatgtaagttagcactgatactaattattctaacaatgattaatagtta- gaatggctgggtgcagtggcacatagtcccagct ccgcaggaggttgagatgggaggatcgcctggggccaggagtccaaggctatggggcaccatgatcatga 2096 3190953 PPP2R4 YES cactttgtggatgagaaggccgtgaatgagaaccacaaggact 2097 3922999 PKNOX1 YES gcgcccggccgagaatgacatcttaa 2098 3701615 -- NO atggacagcttcaaagggcagtttgggggtttctgtttattttcctgtatgttctggtcacctcaatcatcta- accagaagaactggcccaaaattaggcacaag aaaaaaggaaaaagtctagccctgccacataactcctggaactggttgcagaaactgaac 2099 2528729 -- NO gggaagacacgaagggagggcgctg 2100 3188305 -- NO ggatagcttctattgtggacgtggaatcc 2101 3578798 -- NO agatctactcctggatgcgggtacaggacagcatccccagactgtttgtaaagtctcatgtgatacatggagg- gcaggcct 2102 3810041 -- NO agcagaagcaaacgggggtgtctcaggagggggccccgtttccttcttgtaaagctgctcccacccacagcca- cactccattcagtcaggtttatgtgctgtt cttccttgtcccttatgaggtagaaccatcaccttgcgtgcaaagcagctta 2103 2520084 MGC13057 NO ggtgtctgtcggtctttgcttgtcagctgt 2104 2615285 -- NO gtgtttgtgctcaatgtaagagcaaggaaggtgcgggaagatgagggggatgaggcgcaggagtacagggctg- ttattca 2105 2676383 NEK4 YES tggtagagtggtttgtacagatcgccatggctttgcag 2106 3337536 -- NO aggcttcttgcacaggcagaaggggct 2107 3670582 -- NO tacgtgcccaagaatcaatccaatccaactgataacattttctctgaagatagctgcctcttcaaatactggt- acagagattcaagaagctgtaccacagacca tcagtt 2108 2359853 -- NO cccatttttcattaggtccaggtgtatccaaatgttgcca 2109 3349998 -- NO tgatgtggccccgattgcagaattgagttggaggctgaagcatgtgagctctgatccttgcc 2110 3431977 -- NO cttccctctggaagactaacatgtactgctgaagtcttgttcagtgtccttctagccccagactttgcagcct- accaacatggactgagacagggaaagcgtg ggcaagtgagttccatactctaattttcctacagaagcatcctaagtggtgtgtgggttctcagatcaag- tcacaaacacattcacagcccatgatatcgtacaa cactactttttagttcaaattaattatgagtaacaacagactatctgccaaaatagggagctgca 2111 2482372 ACYP2 YES agctaggaaaataggagtggttggctg 2112 2619332 SS18L2 YES cattgcagatgccagtccaaccagcac 2113 3810037 -- NO cccgtggctctaaaagtattatccgaaatcaaccagtcacccctttcaccttctctcagtttaaaaatggatc- cagtgcatacccaatag 2114 2944959 -- NO gtaggaatcaaacatagcgccatctatctgctttttatattatcctacactattttaaaaactgctcaacagt- cttatacagaaatctttaaaagatagacaggataa catgctatattaaccccaccattgaaataatccaacaccatcacgattccgattaagagaagaaaaaaat- cttttttttttctttttttttctttttttctttttttttttccga aaccactcgccctccactgactgcccctgtaccacatcaaacagtctcctctcctccacgcctccggggt- ctgggaagtctcacctcactgatttc

TABLE-US-00004 TABLE 4 Differentially expressed RNA transcripts used to plot hierarchical clustering and expression matrix (`heat map`) in FIG. 1B. The 526 RNA transcripts represent a subset of the differentially expressed transcripts (Table 3) between patients in the three clinical status groups (i.e., `SYS`, `PSA` and `NED`) disease using linear regression and a p-value cut-off of p < 0.01. Weighting factors were from the regression coeffecient values; positive and negative values indicated transcripts correlated to increased expression in `SYS` and `NED` disease, respectively with intermediate expression values in the `PSA` disease group. Weighting factors were used to derive 526-metagene values in FIG. 2. SEQ ID No Weights 1 -6.08 2 -5.71 3 -5.68 4 -5.39 5 -5.26 6 -4.84 7 -4.7 8 -4.68 9 -4.66 10 -4.55 11 -4.53 12 -4.47 13 -4.4 14 -4.37 15 -4.32 16 -4.27 17 -4.23 18 -4.2 19 -4.18 20 -4.1 21 -4.09 22 -4.06 23 -4.03 24 -4.02 25 -4.01 26 -4 27 -3.96 28 -3.95 29 -3.95 30 -3.95 31 -3.95 32 -3.92 33 -3.91 34 -3.88 35 -3.86 36 -3.85 37 -3.8 38 -3.8 39 -3.79 40 -3.74 41 -3.73 42 -3.73 43 -3.71 44 -3.7 45 -3.7 46 -3.7 47 -3.68 48 -3.67 49 -3.66 50 -3.66 51 -3.65 52 -3.65 53 -3.64 54 -3.64 55 -3.63 56 -3.62 57 -3.6 58 -3.6 59 -3.59 60 -3.58 61 -3.58 62 -3.58 63 -3.58 64 -3.58 65 -3.57 66 -3.57 67 -3.57 68 -3.55 69 -3.52 70 -3.51 71 -3.5 72 -3.5 73 -3.49 74 -3.48 75 -3.48 76 -3.47 77 -3.47 78 -3.47 79 -3.47 80 -3.46 81 -3.45 82 -3.45 83 -3.44 84 -3.43 85 -3.43 86 -3.43 87 -3.43 88 -3.42 89 -3.41 90 -3.41 91 -3.4 92 -3.4 93 -3.39 94 -3.38 95 -3.36 96 -3.36 97 -3.36 98 -3.36 99 -3.35 100 -3.35 101 -3.35 102 -3.34 103 -3.34 104 -3.34 105 -3.33 106 -3.33 107 -3.32 108 -3.32 109 -3.31 110 -3.31 111 -3.3 112 -3.3 113 -3.3 114 -3.3 115 -3.27 116 -3.27 117 -3.26 118 -3.26 119 -3.26 120 -3.25 121 -3.25 122 -3.24 123 -3.24 124 -3.23 125 -3.23 126 -3.22 127 -3.22 128 -3.22 129 -3.22 130 -3.22 131 -3.21 132 -3.21 133 -3.21 134 -3.2 135 -3.19 136 -3.19 137 -3.19 138 -3.19 139 -3.18 140 -3.17 141 -3.17 142 -3.16 143 -3.16 144 -3.15 145 -3.14 146 -3.14 147 -3.13 148 -3.13 149 -3.12 150 -3.12 151 -3.11 152 -3.11 153 -3.11 154 -3.11 155 -3.1 156 -3.1 157 -3.09 158 -3.09 159 -3.09 160 -3.08 161 -3.08 162 -3.08 163 -3.07 164 -3.07 165 -3.07 166 -3.07 167 -3.07 168 -3.07 169 -3.06 170 -3.06 171 -3.06 172 -3.05 173 -3.05 174 -3.05 175 -3.05 176 -3.04 177 -3.03 178 -3.03 179 -3.03 180 -3.02 181 -3.02 182 -3.02 183 -3.01 184 -3.01 185 -3 186 -3 187 -2.96 188 -2.96 189 -2.96 190 -2.95 191 -2.95 192 -2.95 193 -2.94 194 -2.94 195 -2.94 196 -2.93 197 -2.92 198 -2.92 199 -2.92 200 -2.92 201 -2.91 202 -2.91 203 -2.9 204 -2.89 205 -2.89 206 -2.88 207 -2.88 208 -2.87 209 -2.87 210 -2.87 211 -2.86 212 -2.85 213 -2.85 914 5.32 915 5.27 916 4.82 917 4.64 918 4.59 919 4.54 920 4.49 921 4.45 922 4.43 923 4.38 924 4.38 925 4.36 926 4.36 927 4.33 928 4.27 929 4.27 930 4.18 931 4.17 932 4.13 933 4.12

934 4.08 935 4.08 936 4.07 937 4.07 938 4.04 939 4.03 940 4.03 941 4.02 942 4.02 943 4.01 944 3.97 945 3.95 946 3.95 947 3.95 948 3.95 949 3.92 950 3.92 951 3.9 952 3.89 953 3.88 954 3.84 955 3.84 956 3.83 957 3.8 958 3.8 959 3.8 960 3.79 961 3.77 962 3.76 963 3.75 964 3.74 965 3.72 966 3.71 967 3.71 968 3.71 969 3.7 970 3.7 971 3.69 972 3.69 973 3.68 974 3.67 975 3.66 976 3.65 977 3.64 978 3.63 979 3.62 980 3.62 981 3.61 982 3.61 983 3.6 984 3.6 985 3.59 986 3.59 987 3.58 988 3.58 989 3.57 990 3.57 991 3.56 992 3.56 993 3.55 994 3.55 995 3.55 996 3.55 997 3.54 998 3.54 999 3.54 1000 3.54 1001 3.54 1002 3.53 1003 3.53 1004 3.53 1005 3.53 1006 3.53 1007 3.53 1008 3.52 1009 3.52 1010 3.51 1011 3.51 1012 3.5 1013 3.49 1014 3.49 1015 3.48 1016 3.48 1017 3.48 1018 3.48 1019 3.47 1020 3.46 1021 3.45 1022 3.45 1023 3.44 1024 3.44 1025 3.44 1026 3.43 1027 3.43 1028 3.42 1029 3.41 1030 3.41 1031 3.41 1032 3.41 1033 3.4 1034 3.4 1035 3.4 1036 3.39 1037 3.39 1038 3.39 1039 3.39 1040 3.38 1041 3.38 1042 3.38 1043 3.38 1044 3.37 1045 3.37 1046 3.37 1047 3.36 1048 3.35 1049 3.35 1050 3.35 1051 3.34 1052 3.34 1053 3.33 1054 3.33 1055 3.33 1056 3.32 1057 3.31 1058 3.31 1059 3.31 1060 3.31 1061 3.3 1062 3.3 1063 3.3 1064 3.29 1065 3.29 1066 3.29 1067 3.28 1068 3.27 1069 3.27 1070 3.27 1071 3.27 1072 3.26 1073 3.26 1074 3.25 1075 3.24 1076 3.24 1077 3.24 1078 3.22 1079 3.22 1080 3.22 1081 3.21 1082 3.21 1083 3.2 1084 3.2 1085 3.2 1086 3.2 1087 3.2 1088 3.19 1089 3.19 1090 3.19 1091 3.19 1092 3.19 1093 3.18 1094 3.18 1095 3.18 1096 3.18 1097 3.18 1098 3.17 1099 3.17 1100 3.17 1101 3.16 1102 3.16 1103 3.16 1104 3.16 1105 3.15 1106 3.15 1107 3.15 1108 3.15 1109 3.14 1110 3.14 1111 3.14 1112 3.14 1113 3.13 1114 3.13 1115 3.12 1116 3.12 1117 3.12 1118 3.11 1119 3.11 1120 3.11 1121 3.11 1122 3.1 1123 3.1 1124 3.1 1125 3.09 1126 3.09 1127 3.09 1128 3.09 1129 3.09 1130 3.08 1131 3.08 1132 3.08 1133 3.08 1134 3.08 1135 3.07 1136 3.07 1137 3.07 1138 3.06 1139 3.06 1140 3.06 1141 3.06 1142 3.05 1143 3.05 1144 3.05 1145 3.05 1146 3.05 1147 3.04 1148 3.04 1149 3.04 1150 3.04 1151 3.04 1152 3.03 1153 3.03 1154 3.03 1155 3.03 1156 3.02 1157 3.02 1158 3.02 1159 3.01 1160 3.01 1161 3.01 1162 3.01 1163 3.01 1164 3.01 1165 3 1166 3 1167 3 1168 3 1169 3 1170 2.99 1171 2.99 1172 2.99 1173 2.99 1174 2.99 1175 2.99 1176 2.99 1177 2.98 1178 2.98 1179 2.97 1180 2.97 1181 2.97 1182 2.97 1183 2.96 1184 2.96

1185 2.96 1186 2.96 1187 2.96 1188 2.96 1189 2.95 1190 2.94 1191 2.94 1192 2.94 1193 2.94 1194 2.93 1195 2.93 1196 2.93 1197 2.93 1198 2.93 1199 2.92 1200 2.92 1201 2.91 1202 2.91 1203 2.91 1204 2.91 1205 2.9 1206 2.89 1207 2.89 1208 2.89 1209 2.89 1210 2.88 1211 2.88 1212 2.88 1213 2.87 1214 2.86 1215 2.86 1216 2.86 1217 2.86 1218 2.86 1219 2.85 1220 2.85 1221 2.85 1222 2.85 1223 2.85 1224 2.85 1225 2.85 1226 2.85

TABLE-US-00005 TABLE 5 Differentially expressed RNA transcripts used to plot hierarchical clustering and expression matrix (`heat map`) in FIG. 1C. The 148 RNA transcripts represent a subset of the most differentially expressed transcripts between patients with clinically significant `recurrent` (i.e., `SYS`) and `non-recurrent` (i.e., `PSA` and `NED`) disease. Weighting factors were from the test statistic values; positive and negative values indicated transcripts correlated to increased expression in recurrent and non-recurrent disease, respectively. Weighting factors were used to derive 148-metagene values, which were converted by scaling and normalizing into `POP` scores depicted in FIG. 7. SEQ ID No Weights 1 -4.1 2 -4.21 3 -5.48 4 -3.04 6 -3.73 8 -3.88 14 -3.78 20 -3.14 32 -3.87 33 -3.75 36 -4.93 42 -3.46 45 -3.1 46 -4.14 60 -5.72 63 -4.79 65 -3.82 66 -4.02 67 -3.37 69 -3.25 79 -3.1 86 -3.57 88 -4.54 96 -3.68 100 -3.63 104 -2.93 115 -3.29 129 -3.91 130 -3.32 181 -3.27 182 -3.37 187 -3.56 189 -3.44 194 -2.09 217 -4 225 -4.01 241 -4.16 265 -3.86 280 -4.02 293 -3.36 295 -3.57 334 -3.36 355 -3.44 387 -3.73 400 -3.17 437 -4.02 445 -3.14 460 -3.36 468 -3 536 -3.65 592 -2.7 596 -2.79 684 -2.75 915 3.78 920 4.36 923 3.23 925 3.04 926 4.61 927 3.79 933 3.24 934 3.65 935 3.64 939 4.2 941 4.14 944 3.72 945 4.03 947 4.44 949 3.77 954 4.34 960 3.54 968 3.84 970 3.5 971 4.68 974 3.63 978 5.27 986 2.59 999 4.74 1004 4.5 1005 3.62 1014 4.86 1022 6.29 1023 4.08 1031 3.75 1032 3.49 1039 3.44 1045 3.41 1052 3.28 1060 4.48 1062 4.1 1080 3.97 1093 4.02 1095 3.77 1101 3.55 1108 3.39 1117 3.97 1123 4.03 1124 3.45 1126 3.25 1132 3.51 1146 3.78 1147 3.37 1153 3.71 1164 3.54 1167 3.6 1194 3.2 1208 3.35 1218 3.56 1219 2.96 1233 3.44 1234 3.86 1248 3.56 1261 3.19 1291 2.99 1299 3.74 1300 3.33 1304 3.14 1311 3.66 1314 3.95 1318 3.9 1320 3.45 1324 3.31 1330 3.02 1335 4.35 1341 3.7 1344 2.93 1346 3.51 1357 3.82 1367 3.35 1369 3.75 1372 3.07 1375 3.17 1383 3.67 1390 3.49 1395 3.19 1402 3.45 1416 3.29 1425 3.73 1443 2.97 1453 3.01 1469 3.02 1474 3.52 1489 3.66 1503 3.19 1527 3.25 1551 3.41 1598 3.26 1624 2.91 1689 2.82

TABLE-US-00006 TABLE 6 Genes identified in a literature search as being correlated to clinical outcome or prognosis in prostate cancer patients. Indicated are the gene name and HNGC gene symbol. Gene Name Symbol Aminoadipate-semialdehyde dehydrogenase AASDH ATP-binding cassette, sub-family A (ABC1), member 5 ABCA5 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ABCB1 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 ABCC5 ATP-binding cassette, sub-family G (WHITE), member 2 ABCG2 V-abl Abelson murine leukemia viral oncogene homolog 1 ABL1 Acetyl-Coenzyme A carboxylase alpha ACACA Acyl-Coenzyme A oxidase 1, palmitoyl ACOX1 Acid phosphatase 2, lysosomal ACP2 Acid phosphatase, prostate ACPP Actin, gamma 2, smooth muscle, enteric ACTG2 Aspartoacylase (aminocyclase) 3 ACY3 AF4/FMR2 family, member 3 AFF3 AF4/FMR2 family, member 4 AFF4 Aryl hydrocarbon receptor AHR Absent in melanoma 2 AIM2 V-akt murine thymoma viral oncogene homolog 2 AKT2 Aminolevulinate, delta-, synthase 1 ALAS1 Activated leukocyte cell adhesion molecule ALCAM Aldehyde dehydrogenase 1 family, member A2 ALDH1A2 Anaplastic lymphoma kinase (Ki-1) ALK Arachidonate 12-lipoxygenase ALOX12 Arachidonate 15-lipoxygenase, type B ALOX15B Alpha-methylacyl-CoA racemase AMACR Alanyl (membrane) aminopeptidase (aminopeptidase N, ANPEP aminopeptidase M, microsomal aminopeptidase, CD13, p150) Anthrax toxin receptor 2 ANTXR2 Annexin A2 ANXA2 APEX nuclease (multifunctional DNA repair enzyme) 1 APEX1 Androgen receptor (dihydrotestosterone receptor; testicular AR feminization; spinal and bulbar muscular atrophy; Kennedy disease) V-raf murine sarcoma 3611 viral oncogene homolog ARAF Amphiregulin (schwannoma-derived growth factor) AREG AT rich interactive domain 4A (RBP1-like) ARID4A Armadillo repeat containing 5 ARMC5 Aryl hydrocarbon receptor nuclear translocator ARNT N-acylsphingosine amidohydrolase (acid ceramidase)-like ASAHL ATPase family, AAA domain containing 2 ATAD2 Activating transcription factor 1 ATF1 Ataxia telangiectasia mutated ATM Atrophin 1 ATN1 ATP synthase, H+ transporting, mitochondrial F1 complex, ATP5D delta subunit ATP synthase, H+ transporting, mitochondrial F0 complex, ATP5J subunit F6 Aurora kinase A AURKA Aurora kinase B AURKB AXL receptor tyrosine kinase AXL Beta-2-microglobulin B2M BCL2-antagonist of cell death BAD BAI1-associated protein 2-like 2 BAIAP2L2 BCL2-antagonist/killer 1 BAK1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal BAP1 hydrolase) BRCA1 associated RING domain 1 BARD1 B-cell CLL/lymphoma 2 BCL2 BCL2-like 1 BCL2L1 B-cell CLL/lymphoma 3 BCL3 Breakpoint cluster region BCR BCS1-like (yeast) BCS1L Biglycan BGN Baculoviral IAP repeat-containing 2 BIRC2 Baculoviral IAP repeat-containing 3 BIRC3 Baculoviral IAP repeat-containing 5 (survivin) BIRC5 Baculoviral IAP repeat-containing 7 (livin) BIRC7 Bloom syndrome BLM BMI1 polycomb ring finger oncogene BMI1 Bone morphogenetic protein 4 BMP4 BolA homolog 2 (E. coli) BOLA2 V-raf murine sarcoma viral oncogene homolog B1 BRAF Breast cancer 1, early onset BRCA1 Breast cancer 2, early onset BRCA2 BTB (POZ) domain containing 14B BTBD14B Bruton agammaglobulinemia tyrosine kinase BTK BUB1 budding uninhibited by benzimidazoles 1 homolog BUB1 (yeast) Chromosome 15 open reading frame 33 C15orf33 Chromosome 17 open reading frame 56 C17orf56 Chromosome 17 open reading frame 57 C17orf57 Chromosome 1 open reading frame 115 C1orf115 Chromosome 1 open reading frame 77 C1orf77 Chromosome 2 open reading frame 33 C2orf33 Chromosome 2 open reading frame 37 C2orf37 Chromosome 3 open reading frame 14 C3orf14 Chromosome 8 open reading frame 32 C8orf32 Chromosome 8 open reading frame 53 C8orf53 Chromosome 8 open reading frame 76 C8orf76 Calcium channel, voltage-dependent, beta 4 subunit CACNB4 Calmodulin binding transcription activator 1 CAMTA1 Caspase 2, apoptosis-related cysteine peptidase (neural CASP2 precursor cell expressed, developmentally down-regulated 2) Caspase 3, apoptosis-related cysteine peptidase CASP3 Caspase 8, apoptosis-related cysteine peptidase CASP8 Caveolin 1, caveolae protein, 22 kDa CAV1 Cas-Br-M (murine) ecotropic retroviral transforming CBL sequence Cholecystokinin CCK Cyclin A2 CCNA2 Cyclin B1 CCNB1 Cyclin C CCNC Cyclin D1 CCND1 Cyclin E1 CCNE1 Cyclin H CCNH CD34 molecule CD34 CD38 molecule CD38 CD40 molecule, TNF receptor superfamily member 5 CD40 CD44 molecule (Indian blood group) CD44 CD59 molecule, complement regulatory protein CD59 CD69 molecule CD69 CD9 molecule CD9 Cell division cycle 2, G1 to S and G2 to M CDC2 Cell division cycle 25 homolog A (S. pombe) CDC25A Cell division cycle 25 homolog B (S. pombe) CDC25B Cell division cycle 25 homolog C (S. pombe) CDC25C CDC42 effector protein (Rho GTPase binding) 5 CDC42EP5 Cadherin 1, type 1, E-cadherin (epithelial) CDH1 Cadherin 11, type 2, OB-cadherin (osteoblast) CDH11 Cadherin 13, H-cadherin (heart) CDH13 Cyclin-dependent kinase 10 CDK10 Cyclin-dependent kinase 2 CDK2 Cyclin-dependent kinase 4 CDK4 Cyclin-dependent kinase 6 CDK6 Cyclin-dependent kinase 7 CDK7 Cyclin-dependent kinase 9 CDK9 Cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A Cyclin-dependent kinase inhibitor 1B (p27, Kip1) CDKN1B CDKN2A interacting protein N-terminal like CDKN2AIPNL Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) CDKN2C Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual CDKN3 specificity phosphatase) CCAAT/enhancer binding protein (C/EBP), alpha CEBPA Centrosomal protein 135 kDa CEP135 Centrosomal protein 70 kDa CEP70 Chromatin assembly factor 1, subunit A (p150) CHAF1A CHK1 checkpoint homolog (S. pombe) CHEK1 Chromogranin A (parathyroid secretory protein 1) CHGA Chromatin accessibility complex 1 CHRAC1 Ceroid-lipofuscinosis, neuronal 5 CLN5 Clusterin CLU Calponin 1, basic, smooth muscle CNN1 Cannabinoid receptor 1 (brain) CNR1 Collagen, type XVIII, alpha 1 COL18A1 Collagen, type I, alpha 1 COL1A1 Collagen, type IV, alpha 3 (Goodpasture antigen) COL4A3 COMM domain containing 5 COMMD5 Catechol-O-methyltransferase COMT Coatomer protein complex, subunit beta 2 (beta prime) COPB2 COP9 constitutive photomorphogenic homolog subunit 5 COPS5 (Arabidopsis) Cytoplasmic polyadenylation element binding protein 3 CPEB3 Cysteine-rich secretory protein 3 CRISP3 V-crk sarcoma virus CT10 oncogene homolog (avian) CRK V-crk sarcoma virus CT10 oncogene homolog (avian)-like CRKL Colony stimulating factor 1 receptor, formerly McDonough CSF1R feline sarcoma viral (v-fms) oncogene homolog Colony stimulating factor 2 (granulocyte-macrophage) CSF2 Colony stimulating factor 3 receptor (granulocyte) CSF3R C-src tyrosine kinase CSK Cystatin B (stefin B) CSTB Connective tissue growth factor CTGF Collagen triple helix repeat containing 1 CTHRC1 Catenin (cadherin-associated protein), alpha 1, 102 kDa CTNNA1 Catenin (cadherin-associated protein), beta 1, 88 kDa CTNNB1 Cathepsin B CTSB Cathepsin L1 CTSL1 Cortactin CTTN Cullin 2 CUL2 Chemokine (C--X--C motif) ligand 14 CXCL14 Chemokine (C--X--C motif) ligand 9 CXCL9 Chromosome X open reading frame 41 CXorf41 Cytochrome b5 type A (microsomal) CYB5A Cytoplasmic FMR1 interacting protein 1 CYFIP1 Cytochrome P450, family 27, subfamily A, polypeptide 1 CYP27A1 Cytochrome P450, family 2, subfamily C, polypeptide 9 CYP2C9 Cytochrome P450, family 3, subfamily A, polypeptide 5 CYP3A5 Disabled homolog 2, mitogen-responsive phosphoprotein DAB2 (Drosophila) Death associated protein 3 DAP3 Death-associated protein kinase 1 DAPK1 Deleted in colorectal carcinoma DCC Dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl- DCI Coenzyme A isomerase) Decorin DCN Dynactin 2 (p50) DCTN2 Damage-specific DNA binding protein 2, 48 kDa DDB2 Dopa decarboxylase (aromatic L-amino acid decarboxylase) DDC Development and differentiation enhancing factor 1 DDEF1 DNA-damage-inducible transcript 3 DDIT3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 DDX6 2,4-dienoyl CoA reductase 2, peroxisomal DECR2 DEK oncogene (DNA binding) DEK DENN/MADD domain containing 3 DENND3 DEP domain containing 1B DEPDC1B DEP domain containing 6 DEPDC6 Diacylglycerol kinase, alpha 80 kDa DGKA DEAH (Asp-Glu-Ala-His) box polypeptide 9 DHX9 Deiodinase, iodothyronine, type II DIO2 DIRAS family, GTP-binding RAS-like 3 DIRAS3 Dyskeratosis congenita 1, dyskerin DKC1 DKEZP564O0823 protein DKEZP564O0823 Discs, large homolog 3 (neuroendocrine-dlg, Drosophila) DLG3 Discs, large (Drosophila) homolog-associated protein 1 DLGAP1 Deleted in malignant brain tumors 1 DMBT1 Dedicator of cytokinesis 5 DOCK5 Desmoplakin DSP E2F transcription factor 1 E2F1 E2F transcription factor 2 E2F2 E2F transcription factor 3 E2F3 E2F transcription factor 4, p107/p130-binding E2F4 Endothelial differentiation, lysophosphatidic acid G-protein- EDG7 coupled receptor, 7 Endothelin receptor type B EDNRB Eukaryotic translation elongation factor 1 alpha 1 EEF1A1 Embryonal Fyn-associated substrate EFS Epidermal growth factor (beta-urogastrone) EGF Epidermal growth factor receptor (erythroblastic leukemia EGFR viral (v-erb-b) oncogene homolog, avian) Early growth response 2 (Krox-20 homolog, Drosophila) EGR2 Early growth response 3 EGR3 Euchromatic histone-lysine N-methyltransferase 1 EHMT1 Euchromatic histone-lysine N-methyltransferase 2 EHMT2 Eukaryotic translation initiation factor 2-alpha kinase 2 EIF2AK2 Eukaryotic translation initiation factor 3, subunit H EIF3H ELK1, member of ETS oncogene family ELK1 ELK3, ETS-domain protein (SRF accessory protein 2) ELK3 Elongation factor RNA polymerase II ELL Elongation factor RNA polymerase II-like 3 ELL3 Epithelial membrane protein 2 EMP2 Ectonucleotide pyrophosphatase/phosphodiesterase 2 ENPP2 (autotaxin) Enhancer of yellow 2 homolog (Drosophila) ENY2 EPH receptor A1 EPHA1 EPH receptor B4 EPHB4 Epsin 1 EPN1 Erythropoietin EPO Epidermal growth factor receptor pathway substrate 15 EPS15 Epidermal growth factor receptor pathway substrate 8 EPS8 V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, ERBB2

neuro/glioblastoma derived oncogene homolog (avian) V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 ERBB3 (avian) V-erb-a erythroblastic leukemia viral oncogene homolog 4 ERBB4 (avian) Excision repair cross-complementing rodent repair ERCC1 deficiency, complementation group 1 (includes overlapping antisense sequence) Excision repair cross-complementing rodent repair ERCC2 deficiency, complementation group 2 (xeroderma pigmentosum D) Excision repair cross-complementing rodent repair ERCC3 deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) Excision repair cross-complementing rodent repair ERCC4 deficiency, complementation group 4 Excision repair cross-complementing rodent repair ERCC5 deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome)) Excision repair cross-complementing rodent repair ERCC6 deficiency, complementation group 6 V-ets erythroblastosis virus E26 oncogene homolog (avian) ERG Endoplasmic reticulum to nucleus signaling 2 ERN2 Estrogen receptor 1 ESR1 Estrogen receptor 2 (ER beta) ESR2 V-ets erythroblastosis virus E26 oncogene homolog 1 ETS1 (avian) V-ets erythroblastosis virus E26 oncogene homolog 2 ETS2 (avian) Ets variant gene 1 ETV1 Ets variant gene 4 (E1A enhancer binding protein, E1AF) ETV4 Ets variant gene 6 (TEL oncogene) ETV6 Even-skipped homeobox 1 EVX1 Exocyst complex component 2 EXOC2 Exostoses (multiple) 1 EXT1 Exostoses (multiple) 2 EXT2 Enhancer of zeste homolog 2 (Drosophila) EZH2 Ezrin EZR Coagulation factor II (thrombin) receptor F2R Coagulation factor V (proaccelerin, labile factor) F5 Family with sequence similarity 114, member A1 FAM114A1 Family with sequence similarity 13, member C1 FAM13C1 Family with sequence similarity 49, member B FAM49B Family with sequence similarity 84, member B FAM84B Family with sequence similarity 8, member A1 FAM8A1 Fanconi anemia, complementation group A FANCA Fanconi anemia, complementation group G FANCG Fas (TNF receptor superfamily, member 6) FAS Fas ligand (TNF superfamily, member 6) FASLG Fatty acid synthase FASN Fibulin 1 FBLN1 F-box protein 32 FBXO32 F-box and WD repeat domain containing 11 FBXW11 Farnesyl diphosphate synthase (farnesyl pyrophosphate FDPS synthetase, dimethylallyltranstransferase, geranyltranstransferase) Fer (fps/fes related) tyrosine kinase (phosphoprotein FER NCP94) Feline sarcoma oncogene FES FEV (ETS oncogene family) FEV Fibroblast growth factor 12 FGF12 Fibroblast growth factor 3 (murine mammary tumor virus FGF3 integration site (v-int-2) oncogene homolog) Fibroblast growth factor 5 FGF5 Fibroblast growth factor 8 (androgen-induced) FGF8 Fibroblast growth factor 9 (glia-activating factor) FGF9 Fibroblast growth factor receptor 1 (fms-related tyrosine FGFR1 kinase 2, Pfeiffer syndrome) Fibroblast growth factor receptor 2 (bacteria-expressed FGFR2 kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) Fibroblast growth factor receptor 4 FGFR4 Fragile histidine triad gene FHIT Folliculin FLCN Friend leukemia virus integration 1 FLI1 Hypothetical protein FLJ90709 FLJ90709 Fms-related tyrosine kinase 1 (vascular endothelial growth FLT1 factor/vascular permeability factor receptor) Fms-related tyrosine kinase 4 FLT4 Flavin containing monooxygenase 5 FMO5 Fibromodulin FMOD Folate hydrolase (prostate-specific membrane antigen) 1 FOLH1 Folate receptor 1 (adult) FOLR1 V-fos FBJ murine osteosarcoma viral oncogene homolog FOS FK506 binding protein 12-rapamycin associated protein 1 FRAP1 Frizzled-related protein FRZB FYN oncogene related to SRC, FGR, YES FYN Frizzled homolog 7 (Drosophila) FZD7 Gamma-aminobutyric acid (GABA) A receptor, gamma 2 GABRG2 Growth arrest and DNA-damage-inducible, alpha GADD45A G protein beta subunit-like GBL Gastrulation brain homeobox 2 GBX2 Ganglioside-induced differentiation-associated protein 1 GDAP1 Growth differentiation factor 15 GDF15 Glioma-associated oncogene homolog 1 (zinc finger protein) GLI1 Glutaredoxin 2 GLRX2 GPI anchored molecule like protein GML Geminin, DNA replication inhibitor GMNN Guanine nucleotide binding protein (G protein), alpha 15 GNA15 GNAS complex locus GNAS Guanine nucleotide binding protein (G protein), beta GNB1 polypeptide 1 Glucosamine (UDP-N-acetyl)-2-epimerase/N- GNE acetylmannosamine kinase N-acetylglucosamine-1-phosphate transferase, alpha and GNPTAB beta subunits Golgi membrane protein 1 GOLM1 Golgi-localized protein GOLSYN G protein-coupled receptor 137B GPR137B Growth factor receptor-bound protein 2 GRB2 Growth factor receptor-bound protein 7 GRB7 Gremlin 2, cysteine knot superfamily, homolog (Xenopus GREM2 laevis) Gastrin-releasing peptide receptor GRPR Glycogen synthase kinase 3 alpha GSK3A Glutathione S-transferase pi GSTP1 Glucuronidase, beta GUSB H1 histone family, member X H1FX Heparin-binding EGF-like growth factor HBEGF HCCA2 protein HCCA2 Host cell factor C1 (VP16-accessory protein) HCFC1 Hemopoietic cell kinase HCK Histone deacetylase 1 HDAC1 Histone deacetylase 7A HDAC7A Hepatoma-derived growth factor (high-mobility group HDGF protein 1-like) HECT, C2 and WW domain containing E3 ubiquitin protein HECW2 ligase 2 Hypoxia-inducible factor 1, alpha subunit (basic helix-loop- HIF1A helix transcription factor) Hydroxymethylbilane synthase HMBS 3-hydroxy-3-methylglutaryl-Coenzyme A reductase HMGCR Hyaluronan-mediated motility receptor (RHAMM) HMMR Hook homolog 1 (Drosophila) HOOK1 Homeobox A9 HOXA9 Homeobox C4 HOXC4 Hepsin (transmembrane protease, serine 1) HPN Hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan HPRT1 syndrome) V-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS Hydroxysteroid (17-beta) dehydrogenase 4 HSD17B4 Hydroxysteroid (17-beta) dehydrogenase 6 homolog HSD17B6 (mouse) Heat shock transcription factor 4 HSF4 Heat shock 27 kDa protein 1 HSPB1 Intercellular adhesion molecule 1 (CD54), human rhinovirus ICAM1 receptor Immediate early response 3 IER3 Interferon, gamma IFNG Interferon gamma receptor 1 IFNGR1 Insulin-like growth factor 1 (somatomedin C) IGF1 Insulin-like growth factor 1 receptor IGF1R Insulin-like growth factor 2 receptor IGF2R Insulin-like growth factor binding protein 1 IGFBP1 Insulin-like growth factor binding protein 2, 36 kDa IGFBP2 Insulin-like growth factor binding protein 3 IGFBP3 Insulin-like growth factor binding protein 6 IGFBP6 IKAROS family zinc finger 1 (Ikaros) IKZF1 Interleukin 11 IL11 Interleukin 12A (natural killer cell stimulatory factor 1, IL12A cytotoxic lymphocyte maturation factor 1, p35) Interleukin 12B (natural killer cell stimulatory factor 2, IL12B cytotoxic lymphocyte maturation factor 2, p40) Interleukin 13 IL13 Interleukin 1, beta IL1B Interleukin 2 IL2 Interleukin 3 (colony-stimulating factor, multiple) IL3 Interleukin 4 IL4 Interleukin 6 (interferon, beta 2) IL6 Interleukin 6 receptor IL6R Interleukin 8 IL8 Integrin-linked kinase ILK Inner membrane protein, mitochondrial (mitofilin) IMMT Inhibin, alpha INHA Inhibin, beta A INHBA Interferon regulatory factor 1 IRF1 Insulin receptor substrate 2 IRS2 ISL LIM homeobox 1 ISL1 Integrin, alpha V (vitronectin receptor, alpha polypeptide, ITGAV antigen CD51) Integrin, beta 1 (fibronectin receptor, beta polypeptide, ITGB1 antigen CD29 includes MDF2, MSK12) Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) ITGB3 Integrin, beta 4 ITGB4 Inositol 1,4,5-trisphosphate 3-kinase A ITPKA Inositol 1,4,5-triphosphate receptor, type 1 ITPR1 Isovaleryl Coenzyme A dehydrogenase IVD Janus kinase 2 (a protein tyrosine kinase) JAK2 Jumonji, AT rich interactive domain 1A JARID1A Jumonji domain containing 2B JMJD2B Jun oncogene JUN Jun B proto-oncogene JUNB Jun D proto-oncogene JUND Potassium channel regulator KCNRG Kinase insert domain receptor (a type III receptor tyrosine KDR kinase) KH domain containing, RNA binding, signal transduction KHDRBS3 associated 3 KIAA0196 KIAA0196 KIAA0922 KIAA0922 KIAA1324 KIAA1324 Kinesin family member C2 KIFC2 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene KIT homolog Kruppel-like factor 6 KLF6 Ketch domain containing 4 KLHDC4 Kallikrein-related peptidase 2 KLK2 Kallikrein-related peptidase 3 KLK3 Kallikrein-related peptidase 4 KLK4 Karyopherin (importin) beta 1 KPNB1 Keratin 15 KRT15 Keratin 5 (epidermolysis bullosa simplex, Dowling- KRT5 Meara/Kobner/Weber-Cockayne types) L1 cell adhesion molecule L1CAM Lymphocyte-specific protein tyrosine kinase LCK Lipocalin 2 LCN2 Leprecan-like 1 LEPREL1 Leucine-rich repeat-containing G protein-coupled receptor 4 LGR4 Ligase I, DNA, ATP-dependent LIG1 Ligase III, DNA, ATP-dependent LIG3 LIM domain only 1 (rhombotin 1) LMO1 LIM domain only 2 (rhombotin-like 1) LMO2 Poly (ADP-ribose) polymerase family, member 1 LOC649459 Lactotransferrin LOC728320 Hypothetical protein BC008326 LOC89944 Lysyl oxidase LOX Leucine rich repeat containing 2 LRRC2 Limbic system-associated membrane protein LSAMP Latent transforming growth factor beta binding protein 2 LTBP2 Mal, T-cell differentiation protein-like MALL Mucosa associated lymphoid tissue lymphoma translocation MALT1 gene 1 Monoamine oxidase B MAOB Mitogen-activated protein kinase kinase 6 MAP2K6 Mitogen-activated protein kinase kinase kinase 8 MAP3K8 Mitogen-activated protein kinase 1 MAPK1 Mitogen-activated protein kinase 10 MAPK10 Mitogen-activated protein kinase 14 MAPK14 MARCKS-like 1 MARCKSL1 MARVEL domain containing 3 MARVELD3 MAS1 oncogene MAS1 Megakaryocyte-associated tyrosine kinase MATK Methyl-CpG binding domain protein 2 MBD2 Melanoma cell adhesion molecule MCAM Mutated in colorectal cancers MCC MCF.2 cell line derived transforming sequence MCF2 Myeloid cell leukemia sequence 1 (BCL2-related) MCL1 Minichromosome maintenance complex component 7 MCM7 Microcephalin 1 MCPH1

Mdm4, transformed 3T3 cell double minute 4, p53 binding MDM4 protein (mouse) Mediator complex subunit 30 MED30 Myocyte enhancer factor 2C MEF2C Meis homeobox 2 MEIS2 Multiple endocrine neoplasia I MEN1 Met proto-oncogene (hepatocyte growth factor receptor) MET Methyltransferase 10 domain containing METT10D Hypothetical protein MGC15523 MGC15523 Antigen identified by monoclonal antibody Ki-67 MKI67 Myeloid leukemia factor 1 MLF1 Myeloid leukemia factor 2 MLF2 MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) MLH1 Myeloid/lymphoid or mixed-lineage leukemia (trithorax MLLT3 homolog, Drosophila); translocated to, 3 Myeloid/lymphoid or mixed-lineage leukemia (trithorax MLLT4 homolog, Drosophila); translocated to, 4 Myeloid/lymphoid or mixed-lineage leukemia (trithorax MLLT6 homolog, Drosophila); translocated to, 6 Matrix metallopeptidase 1 (interstitial collagenase) MMP1 Matrix metallopeptidase 10 (stromelysin 2) MMP10 Matrix metallopeptidase 14 (membrane-inserted) MMP14 Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, MMP2 72 kDa type IV collagenase) Matrix metallopeptidase 3 (stromelysin 1, progelatinase) MMP3 Matrix metallopeptidase 7 (matrilysin, uterine) MMP7 Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, MMP9 92 kDa type IV collagenase) V-mos Moloney murine sarcoma viral oncogene homolog MOS Membrane protein, palmitoylated 7 (MAGUK p55 MPP7 subfamily member 7) Mitochondrial ribosomal protein L13 MRPL13 MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) MSH2 MutS homolog 3 (E. coli) MSH3 MutS homolog 6 (E. coli) MSH6 Microseminoprotein, beta- MSMB Macrophage scavenger receptor 1 MSR1 Macrophage stimulating 1 receptor (c-met-related tyrosine MST1R kinase) Metastasis associated 1 MTA1 5,10-methylenetetrahydrofolate reductase (NADPH) MTHFR Myotrophin MTPN 5-methyltetrahydrofolate-homocysteine methyltransferase MTR Metastasis suppressor 1 MTSS1 Mucin 1, cell surface associated MUC1 MAX dimerization protein 1 MXD1 MAX interactor 1 MXI1 V-myb myeloblastosis viral oncogene homolog (avian) MYB V-myb myeloblastosis viral oncogene homolog (avian)-like 2 MYBL2 Myosin binding protein C, slow type MYBPC1 V-myc myelocytomatosis viral oncogene homolog (avian) MYC V-myc myelocytomatosis viral related oncogene, MYCN neuroblastoma derived (avian) Myosin, heavy chain 11, smooth muscle MYH11 Myosin, light chain 9, regulatory MYL9 Myosin, light chain kinase MYLK N-acetyltransferase 2 (arylamine N-acetyltransferase) NAT2 Neuroblastoma, suppression of tumorigenicity 1 NBL1 Nibrin NBN Non-SMC condensin II complex, subunit D3 NCAPD3 N-myc downstream regulated gene 1 NDRG1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, NDUFB9 22 kDa Neurofilament, heavy polypeptide 200 kDa NEFH Neogenin homolog 1 (chicken) NEO1 Neuropilin (NRP) and tolloid (TLL)-like 2 NETO2 Neurofibromin 1 (neurofibromatosis, von Recklinghausen NF1 disease, Watson disease) Nuclear factor of kappa light polypeptide gene enhancer in NFKB1 B-cells 1 (p105) Nuclear factor of kappa light polypeptide gene enhancer in NFKB2 B-cells 2 (p49/p100) Nuclear factor of kappa light polypeptide gene enhancer in NFKBIA B-cells inhibitor, alpha Nitric oxide synthase 3 (endothelial cell) NOS3 Notch homolog 1, translocation-associated (Drosophila) NOTCH1 Notch homolog 2 (Drosophila) NOTCH2 Notch homolog 4 (Drosophila) NOTCH4 Nephroblastoma overexpressed gene NOV NADPH oxidase 4 NOX4 Aminopeptidase-like 1 NPEPL1 NAD(P)H dehydrogenase, quinone 1 NQO1 Nuclear receptor subfamily 4, group A, member 1 NR4A1 Neuroblastoma RAS viral (v-ras) oncogene homolog NRAS Neuropilin 1 NRP1 Neurotrophic tyrosine kinase, receptor, type 1 NTRK1 Neurotrophic tyrosine kinase, receptor, type 2 NTRK2 Neurotrophic tyrosine kinase, receptor, type 3 NTRK3 Nuclear mitotic apparatus protein 1 NUMA1 Nucleoporin 98 kDa NUP98 Ornithine decarboxylase antizyme 2 OAZ2 Oxysterol binding protein-like 9 OSBPL9 P antigen family, member 4 (prostate associated) PAGE4 PAP associated domain containing 1 PAPD1 Par-3 partitioning defective 3 homolog (C. elegans) PARD3 PAS domain containing serine/threonine kinase PASK Pre-B-cell leukemia homeobox 1 PBX1 Proliferating cell nuclear antigen PCNA PCTAIRE protein kinase 1 PCTK1 Platelet-derived growth factor alpha polypeptide PDGFA Platelet-derived growth factor receptor, alpha polypeptide PDGFRA Platelet-derived growth factor receptor, beta polypeptide PDGFRB Protein disulfide isomerase family A, member 5 PDIA5 PDZ and LIM domain 5 PDLIM5 Phosphatidylethanolamine-binding protein 4 PEBP4 Phosphatidylethanolamine N-methyltransferase PEMT Placental growth factor, vascular endothelial growth factor- PGF related protein Phosphoglycerate kinase 1 PGK1 Progesterone receptor PGR Phosphatase and actin regulator 2 PHACTR2 PHD finger protein 20-like 1 PHF20L1 PHD finger protein 8 PHF8 Phytanoyl-CoA 2-hydroxylase interacting protein-like PHYHIPL Protein inhibitor of activated STAT, 2 PIAS2 Phosphoinositide-3-kinase, catalytic, alpha polypeptide PIK3CA Phosphoinositide-3-kinase, catalytic, delta polypeptide PIK3CD Polycystic kidney and hepatic disease 1 (autosomal PKHD1L1 recessive)-like 1 Phospholipase A2, group IIA (platelets, synovial fluid) PLA2G2A Phospholipase A2, group VII (platelet-activating factor PLA2G7 acetylhydrolase, plasma) Pleiomorphic adenoma gene 1 PLAG1 Plasminogen activator, tissue PLAT Plasminogen activator, urokinase receptor PLAUR Plasminogen PLG Plexin domain containing 1 PLXDC1 Promyelocytic leukemia PML PMS1 postmeiotic segregation increased 1 (S. cerevisiae) PMS1 Polymerase (RNA) I polypeptide C, 30 kDa POLR1C Periostin, osteoblast specific factor POSTN POU class 2 homeobox 1 POU2F1 Peroxisome proliferator-activated receptor delta PPARD Peroxisome proliferator-activated receptor gamma PPARG Protein phosphatase 2 (formerly 2A), regulatory subunit A, PPP2R1B beta isoform Papillary renal cell carcinoma (translocation-associated) PRCC Peroxisomal proliferator-activated receptor A interacting PRIC285 complex 285 Protein kinase, cAMP-dependent, regulatory, type I, alpha PRKAR1A (tissue specific extinguisher 1) Protease, serine, 8 PRSS8 Prostate stem cell antigen PSCA Proteasome (prosome, macropain) 26S subunit, non- PSMD1 ATPase, 1 Patched homolog 1 (Drosophila) PTCH1 Patched homolog 2 (Drosophila) PTCH2 Prostaglandin E receptor 3 (subtype EP3) PTGER3 Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H PTGS1 synthase and cyclooxygenase) Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H PTGS2 synthase and cyclooxygenase) Parathyroid hormone-like hormone PTHLH PTK2 protein tyrosine kinase 2 PTK2 PTK7 protein tyrosine kinase 7 PTK7 Pleiotrophin (heparin binding growth factor 8, neurite PTN growth-promoting factor 1) Protein tyrosine phosphatase type IVA, member 3 PTP4A3 Protein tyrosine phosphatase-like (proline instead of PTPLB catalytic arginine), member b Protein tyrosine phosphatase, receptor type, F PTPRF Protein tyrosine phosphatase, receptor type, G PTPRG Protein tyrosine phosphatase, receptor type, H PTPRH Protein tyrosine phosphatase, receptor type, N polypeptide 2 PTPRN2 Poly-U binding splicing factor 60 KDa PUF60 Purine-rich element binding protein A PURA Paxillin PXN Pyrroline-5-carboxylate reductase 1 PYCR1 Pyrroline-5-carboxylate reductase-like PYCRL Glutaminyl-tRNA synthetase QARS RAB32, member RAS oncogene family RAB32 RAB8A, member RAS oncogene family RAB8A Rabaptin, RAB GTPase binding effector protein 2 RABEP2 RAD21 homolog (S. pombe) RAD21 RAD23 homolog A (S. cerevisiae) RAD23A RAD50 homolog (S. cerevisiae) RAD50 RAD54 homolog B (S. cerevisiae) RAD54B V-raf-1 murine leukemia viral oncogene homolog 1 RAF1 V-ral simian leukemia viral oncogene homolog B (ras RALB related; GTP binding protein) RAP1, GTP-GDP dissociation stimulator 1 RAP1GDS1 RAP2A, member of RAS oncogene family RAP2A Retinoic acid receptor, alpha RARA RAS p21 protein activator (GTPase activating protein) 1 RASA1 Retinoblastoma 1 (including osteosarcoma) RB1 Retinoblastoma binding protein 6 RBBP6 Retinoblastoma-like 2 (p130) RBL2 Retinol dehydrogenase 11 (all-trans/9-cis/11-cis) RDH11 RecQ protein-like (DNA helicase Q1-like) RECQL RecQ protein-like 4 RECQL4 V-rel reticuloendotheliosis viral oncogene homolog (avian) REL V-rel reticuloendotheliosis viral oncogene homolog A, RELA nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) Ret proto-oncogene RET Ras homolog gene family, member A RHOA Ras homolog gene family, member H RHOH Receptor (TNFRSF)-interacting serine-threonine kinase 1 RIPK1 Relaxin 1 RLN1 Ring finger protein 139 RNF139 Ring finger protein 185 RNF185 V-ros UR2 sarcoma virus oncogene homolog 1 (avian) ROS1 Replication protein A1, 70 kDa RPA1 Ras-related GTP binding C RRAGC Related RAS viral (r-ras) oncogene homolog RRAS Rhabdoid tumor deletion region gene 1 RTDR1 S100 calcium binding protein A4 S100A4 Sterile alpha motif domain containing 12 SAMD12 Stearoyl-CoA desaturase 5 SCD5 Sodium channel and clathrin linker 1 SCLT1 Sodium channel, nonvoltage-gated 1 alpha SCNN1A Scribbled homolog (Drosophila) SCRIB Syndecan 2 SDC2 Succinate dehydrogenase complex, subunit B, iron sulfur SDHB (Ip) Succinate dehydrogenase complex, subunit C, integral SDHC membrane protein, 15 kDa SEC14-like 1 (S. cerevisiae) SEC14L1 Sema domain, immunoglobulin domain (Ig), short basic SEMA3F domain, secreted, (semaphorin) 3F Serpin peptidase inhibitor, clade B (ovalbumin), member 5 SERPINB5 Serpin peptidase inhibitor, clade I (neuroserpin), member 1 SERPINI1 Splicing factor 1 SF1 Secreted frizzled-related protein 4 SFRP4 SH3-domain binding protein 2 SH3BP2 SH3 domain containing ring finger 2 SH3RF2 Sonic hedgehog homolog (Drosophila) SHH Seven in absentia homolog 1 (Drosophila) SIAH1 V-ski sarcoma viral oncogene homolog (avian) SKI SKI-like oncogene SKIL Solute carrier family 14 (urea transporter), member 1 (Kidd SLC14A1 blood group) Solute carrier family 20 (phosphate transporter), member 1 SLC20A1 Solute carrier family 22 (extraneuronal monoamine SLC22A3 transporter), member 3 Solute carrier family 25, member 42 SLC25A42 Solute carrier family 44, member 1 SLC44A1 Solute carrier family 45, member 3 SLC45A3 SMAD family member 4 SMAD4 SWI/SNF related, matrix associated, actin dependent SMARCB1 regulator of chromatin, subfamily b, member 1 SWI/SNF related, matrix associated, actin dependent SMARCC1 regulator of chromatin, subfamily c, member 1 Sphingomyelin phosphodiesterase, acid-like 3B SMPDL3B Small nuclear ribonucleoprotein polypeptide E SNRPE Syntrophin, beta 1 (dystrophin-associated protein A1, SNTB1 59 kDa, basic component 1) Syntrophin, beta 2 (dystrophin-associated protein A1, SNTB2 59 kDa, basic component 2) Syntrophin, gamma 1 SNTG1 Suppressor of cytokine signaling 7 SOCS7

Superoxide dismutase 1, soluble (amyotrophic lateral SOD1 sclerosis 1 (adult)) Secreted protein, acidic, cysteine-rich (osteonectin) SPARC SAM pointed domain containing ets transcription factor SPDEF Spleen focus forming virus (SFFV) proviral integration SPI1 oncogene spi1 Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, SPP1 early T-lymphocyte activation 1) Squalene epoxidase SQLE Sulfide quinone reductase-like (yeast) SQRDL V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene SRC homolog (avian) Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 SRD5A2 alpha-steroid delta 4-dehydrogenase alpha 2) ST3 beta-galactoside alpha-2,3-sialyltransferase 1 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ST3GAL5 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 ST6GAL1 Suppression of tumorigenicity 7 ST7 Signal transducer and activator of transcription 1, 91 kDa STAT1 Signal transducer and activator of transcription 3 (acute- STAT3 phase response factor) Signal transducer and activator of transcription 5B STAT5B Six transmembrane epithelial antigen of the prostate 2 STEAP2 Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing STIP1 protein) Serine/threonine kinase 11 STK11 Spleen tyrosine kinase SYK Synapsin I SYN1 Synapsin III SYN3 Tumor-associated calcium signal transducer 1 TACSTD1 TATA box binding protein (TBP)-associated factor, RNA TAF1C polymerase I, C, 110 kDa TAF2 RNA polymerase II, TATA box binding protein TAF2 (TBP)-associated factor, 150 kDa T-cell acute lymphocytic leukemia 1 TAL1 Tax1 (human T-cell leukemia virus type I) binding protein 1 TAX1BP1 TATA box binding protein TBP Transcription factor 7-like 2 (T-cell specific, HMG-box) TCF7L2 TEK tyrosine kinase, endothelial (venous malformations, TEK multiple cutaneous and mucosal) Telomerase reverse transcriptase TERT Transcription factor AP-2 gamma (activating enhancer TFAP2C binding protein 2 gamma) Transcription factor Dp-1 TFDP1 Transcription factor binding to IGHM enhancer 3 TFE3 Trefoil factor 1 TFF1 TRK-fused gene TFG Transferrin receptor (p90, CD71) TFRC Transforming growth factor, alpha TGFA Transforming growth factor, beta 1 TGFB1 Transforming growth factor, beta 2 TGFB2 Transforming growth factor, beta 3 TGFB3 Transforming growth factor, beta-induced, 68 kDa TGFBI Transforming growth factor, beta receptor I (activin A TGFBR1 receptor type II-like kinase, 53 kDa) Transforming growth factor, beta receptor II (70/80 kDa) TGFBR2 Transforming growth factor, beta receptor III TGFBR3 Transglutaminase 2 (C polypeptide, protein-glutamine- TGM2 gamma-glutamyltransferase) Thrombospondin 1 THBS1 Thrombospondin 2 THBS2 Thrombopoietin (myeloproliferative leukemia virus THPO oncogene ligand, megakaryocyte growth and development factor) T-cell lymphoma invasion and metastasis 1 TIAM1 TIMP metallopeptidase inhibitor 2 TIMP2 Thymidine kinase 1, soluble TK1 Transmembrane protein with EGF-like and two follistatin- TMEFF2 like domains 2 Transmembrane protein 134 TMEM134 Transmembrane protein 45B TMEM45B Transmembrane protein 65 TMEM65 Transmembrane protein 71 TMEM71 Transmembrane protease, serine 2 TMPRSS2 Tumor necrosis factor receptor superfamily, member 10a TNFRSF10A Tumor necrosis factor receptor superfamily, member 10b TNFRSF10B Tumor necrosis factor receptor superfamily, member 11a, TNFRSF11A NFKB activator Tumor necrosis factor receptor superfamily, member 11b TNFRSF11B (osteoprotegerin) Tumor necrosis factor receptor superfamily, member 1A TNFRSF1A Tumor necrosis factor (ligand) superfamily, member 10 TNFSF10 Tumor necrosis factor (ligand) superfamily, member 8 TNFSF8 Topoisomerase (DNA) I TOP1 Topoisomerase (DNA) II alpha 170 kDa TOP2A Tumor protein p53 (Li-Fraumeni syndrome) TP53 Tumor protein p53 inducible protein 11 TP53I11 Tumor protein p73 TP73 Translocated promoter region (to activated MET oncogene) TPR TPX2, microtubule-associated, homolog (Xenopus laevis) TPX2 Tripartite motif-containing 38 TRIM38 TRNA methyltransferase 12 homolog (S. cerevisiae) TRMT12 Transient receptor potential cation channel, subfamily M, TRPM8 member 8 Trichorhinophalangeal syndrome I TRPS1 Tuberous sclerosis 1 TSC1 Tuberous sclerosis 2 TSC2 Tetraspanin 13 TSPAN13 Tetraspanin 14 TSPAN14 Tissue specific transplantation antigen P35B TSTA3 Tetratricopeptide repeat domain 29 TTC29 Thymidylate synthetase TYMS TYRO3 protein tyrosine kinase TYRO3 Ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, UBE2J2 yeast) UBX domain containing 3 UBXD3 Vesicle-associated membrane protein 2 (synaptobrevin 2) VAMP2 Vav 1 guanine nucleotide exchange factor VAV1 Vav 2 guanine nucleotide exchange factor VAV2 Versican VCAN Vascular endothelial growth factor A VEGFA Vestigial like 3 (Drosophila) VGLL3 Wiskott-Aldrich syndrome (eczema-thrombocytopenia) WAS WD repeat domain 67 WDR67 WEE1 homolog (S. pombe) WEE1 WNT1 inducible signaling pathway protein 1 WISP1 Wingless-type MMTV integration site family, member 10B WNT10B Wingless-type MMTV integration site family member 2 WNT2 Wingless-type MMTV integration site family, member 2B WNT2B Wingless-type MMTV integration site family, member 5A WNT5A Wingless-type MMTV integration site family, member 8B WNT8B Werner syndrome WRN Wilms tumor 1 WT1 Xanthine dehydrogenase XDH Xeroderma pigmentosum, complementation group A XPA Xeroderma pigmentosum, complementation group C XPC X-ray repair complementing defective repair in Chinese XRCC1 hamster cells 1 X-ray repair complementing defective repair in Chinese XRCC4 hamster cells 4 X-ray repair complementing defective repair in Chinese XRCC5 hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80 kDa) X-ray repair complementing defective repair in Chinese XRCC6 hamster cells 6 (Ku autoantigen, 70 kDa) V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 YES1 Yip1 domain family, member 1 YIPF1 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase YWHAB activation protein, beta polypeptide Zinc finger protein 36, C3H type, homolog (mouse) ZFP36 Zinc finger protein 313 ZNF313 Zinc finger protein 34 ZNF34 Zinc finger protein 511 ZNF511 Zinc finger protein 7 ZNF7

TABLE-US-00007 TABLE 7 RNA transcripts used to derive metagene values for 18-RNA metagene depicted in FIG. 3. The 6-RNA metagene is a subset of the sequences listed in Table 7, also depicted in FIG. 3. 18-RNA metagene scores were scaled and normalized to generate `POP` scores depicted in FIG. 4. Weighting factors were from the linear regression coefficient values; positive and negative values indicated transcripts correlated to increased expression in `SYS` and `NED` disease, respectively with intermediate expression values in the `PSA` disease group. SEQ ID No Weights 1 -6.08 2 -5.71 3 -5.68 4 -5.39 5 -5.26 6 -4.84 7 -4.7 8 -4.68 9 -4.66 10 -4.55 11 -4.53 914 5.32 915 5.27 916 4.82 917 4.64 918 4.59 919 4.54 920 4.49

TABLE-US-00008 TABLE 8 RNA transcripts used to derive metagene values for 20-RNA metagene depicted in FIG. 3. Weighting factors were from the linear regression coefficient values; positive and negative values indicated transcripts correlated to increased expression in `SYS` and `NED` disease, respectively with intermediate expression values in the `PSA` disease group. SEQ ID No Weights 1 -6.08 4 -5.39 6 -4.84 9 -4.66 14 -4.37 15 -4.32 16 -4.27 18 -4.2 19 -4.18 20 -4.1 21 -4.09 915 5.27 916 4.82 917 4.64 920 4.49 922 4.43 928 4.27 929 4.27 931 4.17 935 4.08 936 4.07

TABLE-US-00009 TABLE 9 RNA transcripts used to derive 10-RNA metagene values, which were converted by scaling and normalizing into `POP` scores depicted in FIG. 5. RNA transcripts were identified using Nearest Shrunken Centroids algorithm with leave-1-out cross-validation to distinguish `recurren` (i.e., `SYS`) and `non-recurrent` (i.e., `PSA` and `NED`) disease from Table 3 RNA transcripts. Weighting factors were from the test statistic values; positive and negative values indicated transcripts correlated to increased expression in `recurrent` and `non-recurrent` disease, respectively. Seq ID Weights 3 -5.48 36 -4.93 60 -5.72 63 -4.79 926 4.61 971 4.68 978 5.27 999 4.74 1014 4.86 1022 6.29

TABLE-US-00010 TABLE 10 RNA transcripts used to derive 41-RNA metagene values, which were converted by scaling and normalizing into `POP` scores depicted in FIG. 6. RNA transcripts were identified using Nearest Shrunken Centroids algorithm with leave-1-out cross-validation to distinguish `recurrent` (i.e., `SYS`) and `non-recurrent` (i.e., `PSA` and `NED`) disease from Table 3 RNA transcripts. Weighting factors were from the test statistic values; positive and negative values indicated transcripts correlated to increased expression in `recurrent` and `non-recurrent` disease, respectively. Seq ID Weights 1 -4.1 2 -4.21 3 -5.48 32 -3.87 33 -3.75 36 -4.93 46 -4.14 60 -5.72 63 -4.79 66 -4.02 69 -3.25 88 -4.54 100 -3.63 241 -4.16 265 -3.86 334 -3.36 437 -4.02 920 4.36 925 3.04 934 3.65 945 4.03 947 4.44 954 4.34 971 4.68 978 5.27 999 4.74 1004 4.5 1014 4.86 1022 6.29 1023 4.08 1032 3.49 1080 3.97 1093 4.02 1101 3.55 1164 3.54 1248 3.56 1304 3.14 1311 3.66 1330 3.02 1402 3.45 1425 3.73

[0226] Although the invention has been described with reference to certain specific embodiments, various modifications thereof will be apparent to those skilled in the art without departing from the spirit and scope of the invention. All such modifications as would be apparent to one skilled in the art are intended to be included within the scope of the following claims.

Sequence CWU 0 SQTB SEQUENCE LISTING The patent application contains a lengthy "Sequence Listing" section. A copy of the "Sequence Listing" is available in electronic form from the USPTO web site (http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20110136683A1). An electronic copy of the "Sequence Listing" will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

0 SQTB SEQUENCE LISTING The patent application contains a lengthy "Sequence Listing" section. A copy of the "Sequence Listing" is available in electronic form from the USPTO web site (http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20110136683A1). An electronic copy of the "Sequence Listing" will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

Claims

1. A system for expression-based assessment of prostate cancer recurrence risk, said system comprising one or more polynucleotides, each of said polynucleotides capable of specifically hybridizing to a RNA transcript of a gene selected from the group of genes set forth in Table 3 and/or Table 6.

2. The system of claim 1, wherein said one or more polynucleotides comprise one or more polynucleotide probes for the detection of the respective transcript.

3. The system of claim 1, wherein said one or more polynucleotides comprise one or more primer pairs, each of said primer pairs capable of amplifying a portion of a sequence corresponding to the respective transcript.

4. The system of any one of claims 1, 2 and 3, wherein said transcript comprises a sequence corresponding to one or more of the sequences set forth in SEQ ID NOs: 1-2114.

5. The system of any one of claims 1, 2 and 3, wherein said transcript comprises a sequence corresponding to one or more of the sequences set forth in a SEQ ID NOs: 914-2114.

6. The system according to any one of claims 1 to 5, wherein said system comprises at least 5 polynucleotides.

7. The system according to any one of claims 1 to 5, wherein said system comprises at least 10 polynucleotides.

8. The system according to any one of claims 1 to 5, wherein said system comprises at least 100 polynucleotides.

9. The system of claim 1, wherein each of said one or more polynucleotides comprises a sequence corresponding to, or complementary to, one or more of the sequences set forth in Table 4 or a fragment thereof.

10. The system of claim 1, wherein each of said one or more polynucleotides comprises a sequence corresponding to one or more nucleic acid molecules selected from the group consisting of: (a) a nucleic acid depicted in any one of SEQ ID NOs: 1-2114; (b) an RNA form of any one of the nucleic acids depicted in SEQ ID NOs: 1-2114; (c) a peptide nucleic acid form of any one of the nucleic acids depicted in SEQ ID NOs: 1-2114; (d) a nucleic acid comprising at least 20 consecutive bases of any of (a-c); (e) a nucleic acid comprising at least 25 consecutive bases having at least 90% sequence identity to any of (a-c); and (f) a complement to any of (a-e).

11. The system of claim 1, wherein said transcript comprises one or more of the sequences as set forth in SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21 915-917, 920, 922, 928, 929, 931, 935 and 936.

12. The system of claim 1, wherein said transcript comprises one or more of the sequences as set forth in SEQ ID NOs: 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022.

13. The system of claim 1, wherein said transcript comprises one or more of the sequences as set forth in SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402, 1425.

14. Use of the system according to any one of claims 1, 2 and 4 to 11 for the preparation of a nucleic acid array

15. A nucleic acid array for expression-based assessment of prostate cancer recurrence risk, said array comprising at least ten probes immobilized on a solid support, each of said probes being between about 15 and about 500 nucleotides in length, each of said probes being derived from a sequence corresponding to, or complementary to, a transcript of a gene selected from the group of genes set forth in Table 3, or a portion of said transcript.

16. The nucleic acid array according to claim 15, wherein each of said probes comprises a sequence as set forth in any one of SEQ ID NOs: 1-2114 or complement thereof.

17. A method for expression-based assessment of prostate cancer recurrence risk, said method comprising: (a) determining the expression level of one or more transcripts of one or more genes in a test sample obtained from said subject to provide an expression pattern profile, said one or more genes selected from the group of genes set forth in Table 3, and (c) comparing said expression pattern profile with a reference expression pattern profile.

18. The method of claim 17, wherein an increased relative level of expression of one or more transcripts, a decreased relative level of expression of one or more transcripts, or a combination thereof is used to classify a prostate cancer as recurrent.

19. The method of claim 17, wherein an increased relative level of expression of one or more transcripts, a decreased relative level of expression of one or more transcripts, or a combination thereof is used to classify a prostate cancer as non-recurrent.

20. The method of claim 17; wherein said transcripts comprise a sequence as set forth in any one of SEQ ID NOs: 1-2114 or complement thereof.

21. The method of claim 17, wherein said one or more transcripts comprise one or more sequences as set forth in any one of SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21 915-917, 920, 922, 928, 929, 931, 935 and 936.

22. The method of claim 17, wherein said transcript comprises one or more of the sequences as set forth in SEQ ID NOs: 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022.

23. The method of claim 17, wherein said transcript comprises one or more of the sequences as set forth in SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402, 1425.

24. The method of claim 17, wherein the expression level of the one or more target sequences is determined by a method selected from the group consisting of RT-PCR, Northern blotting, ligase chain reaction, array hybridization, and a combination thereof.

25. The method of any one of claims 17 to 24, further comprising measuring the expression level of at least one control nucleic acid in the sample.

26. The method of any one of claims 17 to 25, wherein the sample is a fine needle aspirate biopsy [FNAB], cytology smear, cytology pellet, or a bulk tissue preparation.

27. The method of any one of claims 17 to 26, wherein the sample is fresh-frozen or fixed.

28. The method of any one of claims 17 to 27, wherein measuring the expression level utilizes a pattern recognition method.

29. The method of claim 28, wherein the pattern recognition method comprises a linear combination of expression levels of the target sequences.

30. The method of claim 28 or 29, wherein the pattern recognition method comprises a nonlinear combination of expression levels of the target sequences.

31. A kit for characterizing the expression of one or more nucleic acid sequences depicted in SEQ ID NOs: 1-2114 comprising one or more nucleic acids selected from: (a) a nucleic acid depicted in any of SEQ ID NOs: 1-2114; (b) an RNA form of any of the nucleic acids depicted in SEQ ID NOs: 1-2114; (c) a peptide nucleic acid form of any of the nucleic acids depicted in SEQ ID NOs: 1-2114; (d) a nucleic acid comprising at least 20 consecutive bases of any of (a-c); (e) a nucleic acid comprising at least 25 consecutive bases having at least 90% sequence identity to any of (a-c); or (f) a complement to any of (a-e); and optionally instructions for correlating the expression level of said one or more nucleic acid sequences with the disease state of prostate cancer tissue.

32. The kit of claim 31, wherein said one or more nucleic acids comprises one or more sequences as set forth in any one of SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21 915-917, 920, 922, 928, 929, 931, 935 and 936.

33. The kit of claim 31, wherein said one or more nucleic acids comprises one or more of the sequences as set forth in SEQ ID NOs: 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022.

34. The kit of claim 31, wherein said one or more nucleic acids comprises one or more of the sequences as set forth in SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402, 1425.

35. The kit of any one of claims 31 to 34, wherein said one or more nucleic acids comprises labeled nucleic acids.

36. The kit of any one of claims 31 to 35, wherein the kit comprises one or more primers or primer pairs that specifically amplify at least a portion of said nucleic acids.

37. The kit of any of claims 31 to 36, wherein the kit further comprises one or more control samples comprising expressed RNA, an amplification product produced therefrom or a surrogate therefore, said control one or more control samples selected from: a sample from non-recurrent prostate cancer; and a sample from recurrent prostate cancer.

38. An array of probe nucleic acids certified for use in expression-based assessment of prostate cancer recurrence risk, wherein said array comprises at least two different probe nucleic acids that specifically hybridize to corresponding different target nucleic acids depicted in one of SEQ ID NOs: 1-2114, an RNA form thereof, or a complement to either thereof.

39. The array of claim 38, further comprising one or more probe nucleic acids that specifically hybridize to house keeping genes.

40. A device for classifying a biological sample from a prostate cancer as recurrent or non-recurrent, the device comprising: means for measuring the expression level of one or more transcripts of one or more genes selected from the group of genes set forth in Table 3 and/or 6; means for correlating the expression level with a classification of prostate cancer status; and means for outputting the prostate cancer status.

41. The device of claim 40, wherein the machine utilizes an algorithm to characterize said expression level.

42. A computer-readable medium comprising one or more digitally-encoded expression pattern profiles representative of the level of expression of one or more transcripts of one or more genes selected from the group of genes set forth in Table 3 and/or 6, each of said one or more expression pattern profiles being associated with a value wherein each of said values is correlated with the presence of recurrent or non-recurrent prostate cancer.