U.S. patent application number 12/440644 was filed with the patent office on 2011-06-02 for diagnosis of hereditary spastic paraplegias (hsp) by indentification of a mutation in the kiaa1840 gene or protein. Invention is credited to Hamid Azzedine, Alexis Brice, Paola Denora, Filippo Santorelli, Giovanni Stevanin.
Application Number | 20110129819 12/440644 |
Document ID | / |
Family ID | 37890642 |
Filed Date | 2011-06-02 |
United States Patent Application | 20110129819 |
Kind Code | A1 |
Azzedine; Hamid ; et al. | June 2, 2011 |
The invention relates to an ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein said mutation is indicative of. an hereditary spastic paraplegias (HSP).
Inventors: | Azzedine; Hamid; (Bagneux, FR) ; Brice; Alexis; (Paris, FR) ; Stevanin; Giovanni; (Sevran, FR) ; Santorelli; Filippo; (Naple, IT) ; Denora; Paola; (Rome, IT) |
Family ID: | 37890642 |
Appl. No.: | 12/440644 |
Filed: | September 11, 2007 |
PCT Filed: | September 11, 2007 |
PCT NO: | PCT/IB07/03535 |
371 Date: | January 4, 2010 |
Current U.S. Class: | 435/6.1 ; 435/7.1; 530/350; 530/388.2; 530/389.1; 536/24.31; 536/24.33 |
Current CPC Class: | C12Q 2600/158 20130101; C12Q 2600/172 20130101; C12Q 1/6883 20130101; C12Q 2600/156 20130101 |
Class at Publication: | 435/6.1 ; 536/24.31; 536/24.33; 530/350; 530/388.2; 530/389.1; 435/7.1 |
International Class: | C12Q 1/68 20060101 C12Q001/68; C07H 21/00 20060101 C07H021/00; C07K 14/47 20060101 C07K014/47; C07K 16/18 20060101 C07K016/18; G01N 33/68 20060101 G01N033/68 |
Date | Code | Application Number |
---|---|---|
Sep 11, 2006 | EP | 06291433.8 |
Sequence CWU 1
1
18817751DNAhomo sapiens 1atggctgcag aggaaggggt cgcgagtgct
gcttccgccg gcggtagctg gggcaccgcg 60gccatggggc gggttctacc gatgctgttg
gtgccagtcc ccgccgaggc gatggggcag 120ctcggctccc gggcgcagct
gcgcacacag ccggaggctc tggggagcct gacggctgcg 180ggcagcctcc
aagtgctttc tttgacgcct ggcagccggg gcgggggtcg ctgctgcctg
240gagggcccct tctggcactt tctatgggag gattctcgta acagcagcac
accaactgaa 300aagcccaaac tgctcgctct tggtgaaaat tatgaactgc
ttatctatga atttaatttg 360aaagatggaa gatgtgatgc aaccattttg
tatagctgta gtagggaggc attgcaaaag 420ctcattgacg atcaagatat
cagtatttcc ttattgtctt tgagaatcct gtcatttcac 480aataacacat
cattactgtt catcaacaaa tgtgtcatcc tacatattat atttcctgaa
540agagatgctg caattagagt actcaactgt ttcacacttc ccttgcctgc
acaggcagtg 600gacatgatta ttgacacgca gctctgcaga ggaattcttt
ttgttttgag tagtttaggc 660tggatctaca tttttgatgt tgtggatggt
acatatgtag ctcatgtgga tttagcactt 720cacaaagaag acatgtgtaa
tgagcagcaa caggagccag ccaagatttc ttcatttact 780tcactgaaag
tttctcaaga cctcgatgtt gcagtgattg tcagctcctc caactccgca
840gttgctctta acttaaattt gtatttcagg caacacccag gacacctact
gtgtgaaaga 900atactagaag atcttcctat tcaaggacct aagggcgtag
atgaagatga tcctgttaac 960tctgcctaca acatgaaact ggccaagttt
tccttccaaa ttgataggtc ttggaaagcc 1020cagctatcat cattgaatga
aacaataaag aactccaaac tggaggtttc ctgttgtgct 1080ccatggttcc
aggatatttt gcatttggag tcacctgaat ctggtaacca cagtacaagt
1140gtgcagagct gggccttcat tccacaggac ataatgcatg ggcaatataa
tgttctacag 1200aaagatcatg ccaagaccag tgatccagga agatcatgga
aaataatgca catcagtgaa 1260caagaggaac ccatagagct taaatgtgtg
tctgtgacag gattcactgc actgtttact 1320tgggaagtgg aaaggatggg
ctataccatt accctctggg atttggagac ccagggcatg 1380cagtgttttt
cccttggcac aaagtgtatt cctgtagaca gtagtggaga ccagcagctg
1440tgctttgttt tgacagagaa tggactctct ctgattttgt ttggtttgac
tcaagaagag 1500tttttaaaca gactcatgat ccatggaagt gccagcactg
tggacactct ttgtcatctc 1560aatggctggg gaaggtgctc aattcccata
catgcactag aggccgggat agaaaatcgt 1620cagctggaca cagtaaattt
ctttttgaag agcaaggaaa atctttttaa tccatcctca 1680aaatcttctg
tatctgatca gtttgatcac ttgtcatccc atttatattt aagaaatgtg
1740gaagagctga taccagcatt ggatttactt tgctcggcaa ttagagaaag
ttattctgaa 1800ccccaaagca aacacttttc agaacaattg cttaatctta
cactgtcttt ccttaacaac 1860caaataaagg agcttttcat tcacactgaa
gaactagatg aacatctgca aaaaggagtg 1920aacattttga ctagctacat
taatgaactt cgaaccttca tgataaagtt tccttggaag 1980ctaacagatg
ctatagatga atatgatgta catgaaaatg tccccaaagt aaaggagagc
2040aatatatgga agaaactcag ctttgaggaa gttattgcca gcgccatttt
aaacaacaaa 2100ataccagagg cacagacttt cttcaggatt gatagtcatt
ctgctcaaaa acttgaggag 2160cttattggca taggcctaaa tttggtcttt
gacaatttaa aaaagaacaa tataaaggaa 2220gcctctgaac ttttgaagaa
tatggggttt gatgtaaaag gccaattgct caagatctgc 2280ttctatacaa
ctaataaaaa tatacgtgac tttttggttg aaattttaaa agaaaaaaat
2340tatttttctg aaaaagagaa aagaactata gacttcgtgc atcaagttga
gaagctttat 2400ttgggacatt tccaagaaaa tatgcaaatc cagtcatttc
ccaggtactg gataaaggaa 2460caagattttt tcaagcacaa gtctgttttg
gactcattcc tgaaatatga ttgtaaagat 2520gaatttaaca aacaggacca
tagaattgtg ttaaattggg ctctgtggtg ggatcaacta 2580acacaagaat
ccatccttct ccccaggata agtccagaag aatacaaatc atattcccct
2640gaagccctct ggagatacct cacagctcgc catgattggt taaacattat
cttatggatt 2700ggagaatttc aaacccagca tagttatgct tcacttcagc
agaacaaatg gccccttctg 2760actgttgatg ttattaacca gaatacttcc
tgtaacaact acatgaggaa tgaaatttta 2820gataagctgg ccaggaatgg
ggtttttttg gcatctgaac tggaagactt tgaatgcttc 2880ctcctaagac
tgagccgtat tggaggtgta atacaggata ccctccctgt tcaaaactac
2940aagaccaaag aaggttggga tttccattct caattcattc tctattgttt
ggagcacagt 3000ctgcagcatc ttctttatgt ctaccttgac tgttacaaac
ttagtcctga aaattgtccc 3060tttttggaaa aaaaagagtt acatgaagca
cacccttggt ttgaattttt agttcagtgt 3120cgacaagttg ccagtaactt
aacagatccc aaactgatct tccaggctag ccttgcaaat 3180gctcagattt
tgattcccac caatcaggcc agtgtaagca gtatgctatt ggaaggacat
3240accctcctgg cccttgctac tacaatgtat tctcctgggg gtgtcagtca
ggttgttcag 3300aatgaagaaa atgaaaactg tttgaagaaa gtggatcccc
agctattgaa gatggcatta 3360actccttacc ccaagctaaa aactgctctc
ttcccacagt gcactcctcc tagtgtcctg 3420ccatctgata ttacaatcta
ccaccttatt cagtcattat caccctttga tcctagcaga 3480ttgtttggct
ggcagtctgc taacacacta gctataggag atgcatggag tcatctccca
3540catttctcta gccctgacct ggttaataaa tatgctatag tggaacgtct
gaattttgct 3600tattatttac ataatgggcg gccatcattt gcatttggta
cttttctggt ccaggaatta 3660atcaagagca agactcccaa gcagctgatc
cagcaagtag gcaatgaagc ctatgttata 3720gggctctcct ccttccacat
accttcaata ggagctgcat gtgtttgttt cttagaattg 3780cttggccttg
acagcctcaa gctcagagtt gatatgaaag tggccaatat aattttgagc
3840tacaagtgca gaaatgaaga tgctcagtac agctttatca gagagtctgt
agccgaaaaa 3900ctatctaaac tagctgatgg tgaaaagaca accacagaag
aattgcttgt tctcttagaa 3960gaaggtacat ggaacagcat tcagcaacag
gaaataaaga ggttatccag tgaatctagc 4020agccaatggg cattagtggt
gcagttctgc aggctacaca atatgaaact aagcatatct 4080taccttagag
aatgtgccaa agcaaatgat tggctgcagt tcattattca cagccaactc
4140cacaactacc acccagcaga ggtgaaatcc cttatccagt acttcagccc
agtcattcaa 4200gaccacttaa ggctggcttt tgagaacttg ccctcagtgc
ccacctccaa aatggacagc 4260gatcaagtct gcaataagtg cccccaggaa
cttcaaggaa gcaaacaaga gatgaccgat 4320ttatttgaaa ttctgctcca
atgctcagag gagccagact cctggcactg gcttctggtt 4380gaagcagtga
aacaacaggc ccctatcctc agtgttctgg cctcatgtct ccagggtgcc
4440agtgccattt cttgtctctg tgtttggatc atcacttctg tggaggacaa
tgttgcaact 4500gaagcaatgg gacacattca ggactcaaca gaggaccata
cctggaacct tgaggatctt 4560tcagtcatct ggagaacatt attaacaaga
caaaagagca aaactctcat cagaggtttc 4620cagcttttct ttaaggattc
cccgttacta ctggtgatgg agatgtatga actgtgtatg 4680ttcttcagga
attataaaga agctgaagct aaacttctgg agtttcagaa gagccttgaa
4740acgcttaaca cagcagccac aaaggtccac cctgtcatcc ctgccatgtg
gctggaggat 4800caggtgtgtt tccttttgaa gcttatgcta cagcagtgta
agacccagta tgagctgggg 4860aagcttttac agctctttgt tgaaagagag
catctcttct ctgatggtcc agatgtgaaa 4920aagctttgca tcctttgcca
gattttgaag gatacatcca tagccattaa tcatacaatt 4980attaccagct
acagcattga gaatcttcag catgaatgta gatctatttt ggaaagactg
5040cagacagatg gacaattcgc tttggccagg agggtagcag aattagctga
gttacctgtg 5100gacaacttgg ttattaaaga gataacacag gaaatgcaga
ccctaaaaca cattgaacag 5160tggtcactaa aacaagcaag aattgacttc
tggaaaaaat gccatgagaa ttttaagaaa 5220aattcaattt caagcaaagc
agcttcttcc tttttctcaa cccaggccca tgtggcatgt 5280gagcacccaa
ctggatggag cagcatggag gagcgccatc tgctgctcac cttggcaggg
5340cactggcttg cccaggagga cgtggtgccc ttggataagc tggaggagct
ggagaagcag 5400atctggctgt gccgcatcac ccagcacact cttggaagaa
atcaggagga aacagagccc 5460agattttctc gacagatctc aactagtggt
gaactttcct ttgatagttt agccagtgag 5520ttttccttct ccaagttggc
tgctctgaac acatcaaaat acttagaact taacagcctt 5580ccatccaaag
agacatgcga gaatagattg gattggaaag agcaggagtc actaaacttt
5640ttgattgggc gcctactgga tgatggctgt gtgcatgaag caagtagagt
atgccggtat 5700tttcattttt ataatccaga tgtcgccttg gtattgcact
gcagagcact ggcctcaggg 5760gaagctagta tggaggatct gcacccagag
atccatgctc tcctacaaag tgctgagctg 5820cttgaggaag aagcacccga
cattccccta aggagagtcc acagcacttc aagtctggat 5880agtcagaagt
ttgtgacagt gccctccagt aatgaagtgg taactaacct ggaagtgctg
5940acaagcaaat gcctccatgg gaagaactac tgtcgacagg tcctctgtct
gtatgatctt 6000gccaaggagt tgggctgttc ctacacagat gttgctgctc
aggatggtga agccatgctc 6060cggaaaatct tggcctctca gcagcctgac
cgatgcaaac gagcccaggc cttcatcagc 6120acacagggcc ttaagccaga
tactgtggct gaactcgtgg cagaagaggt gacacgggag 6180ctgcttactt
catcacaggg aacaggacat aagcagatgt tcaacccaac agaggaaagc
6240cagacatttc ttcagctgac cactctgtgt caagaccgca cattggtagg
catgaagttg 6300ttggataaga tttcctccgt tccccatggg gaactgtctt
gcaccacaga gctcctgatc 6360ctggcccatc attgcttcac cctgacgtgc
cacatggagg gcatcatccg agtcctacag 6420gccgcccaca tgctcacaga
taaccacctg gcccccagtg aggagtatgg gctggtggta 6480cggctcctca
ctggcattgg aaggtacaac gagatgacat acatatttga tttgctgcat
6540aaaaagcact actttgaagt gctaatgagg aagaagttgg atccgagtgg
taccctgaaa 6600acagccctgc tggactacat caaacgctgc cgtcctggag
acagtgaaaa gcacaatatg 6660attgccctgt gcttcagcat gtgccgggag
attggcgaga accacgaggc agctgcccgc 6720atccaactga aattgattga
gtctcagccc tgggaggaca gcctcaagga tgggcaccag 6780ctgaaacaac
tgctgctgaa ggccctgact ctgatgttgg atgcagcaga gagttatgcc
6840aaggactcct gtgtgcgaca ggcccagcac tgtcagcggc tcaccaagtt
gataactctg 6900cagattcact ttctgaacac tggccagaac acaatgctca
tcaacttggg ccgccacaag 6960ctgatggact gtattctggc cctacctcgg
ttctaccagg cttctattgt ggctgaggcc 7020tacgattttg ttccagattg
ggctgaaatt ttataccagc aagtgattct taaaggagac 7080tttaattact
tggaagaatt taagcagcaa aggttattaa agtccagtat atttgaagag
7140atttccaaaa aatataaaca acatcagcct actgacatgg tcatggaaaa
cctgaagaaa 7200ttactcacat attgtgaaga tgtttacctg tattacaagt
tggcatacga acacaagttt 7260tatgaaattg taaatgtgct tctgaaggac
cctcagacag gttgctgtct aaaggacatg 7320ctagcaggtt agatgatttc
ataggtgtct gttttcttgt actgttagca gattctgaca 7380gatgtgatga
gaagaagaat gcattggaga tctttgctaa agttgaacaa tcccggtact
7440gtaccatatc agtcctttgt gggtagtagg tagcaagtaa gaaacttttc
aggaggaaat 7500tcctatttaa aatagattga ttttagatga ttgttcatcc
acaccatttt atatagatac 7560tagtattaag atcaaaagct tcctcttcct
caggacagct tctactttag atgatccaat 7620aatgattaaa gaatacctgt
acctgcagat tccagtttca aagaaattta attattattt 7680acacagttaa
ggaacaggtg atacattttc atttgttaga aactgatctt tctgtaataa
7740aatagatttt c 775122443PRThomo sapiens 2Met Ala Ala Glu Glu Gly
Val Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala
Met Gly Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu
Ala Met Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro
Glu Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu
Ser Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75
80Glu Gly Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser
85 90 95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr
Glu 100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys
Asp Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln
Lys Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser
Leu Arg Ile Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu
Phe Ile Asn Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu
Arg Asp Ala Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro
Leu Pro Ala Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200
205Cys Arg Gly Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile
210 215 220Phe Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu
Ala Leu225 230 235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln
Glu Pro Ala Lys Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser
Gln Asp Leu Asp Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser
Ala Val Ala Leu Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro
Gly His Leu Leu Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile
Gln Gly Pro Lys Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315
320Ser Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg
325 330 335Ser Trp Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys
Asn Ser 340 345 350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln
Asp Ile Leu His 355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser
Thr Ser Val Gln Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met
His Gly Gln Tyr Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys
Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser
Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr
Gly Phe Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440
445Thr Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Phe Ser
450 455 460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln
Gln Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu
Ile Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu
Met Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His
Leu Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu
Glu Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe
Phe Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555
560Lys Ser Ser Val Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr
565 570 575Leu Arg Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu
Cys Ser 580 585 590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys
His Phe Ser Glu 595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu
Asn Asn Gln Ile Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu
Asp Glu His Leu Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser
Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp
Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn
Val Pro Lys Val Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680
685Glu Glu Val Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala
690 695 700Gln Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu
Glu Glu705 710 715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp
Asn Leu Lys Lys Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu
Lys Asn Met Gly Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile
Cys Phe Tyr Thr Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val
Glu Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys
Arg Thr Ile Asp Phe Val His Gln Val Glu Lys Leu Tyr785 790 795
800Leu Gly His Phe Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr
805 810 815Trp Ile Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu
Asp Ser 820 825 830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys
Gln Asp His Arg 835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp
Gln Leu Thr Gln Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro
Glu Glu Tyr Lys Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg
Tyr Leu Thr Ala Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp
Ile Gly Glu Phe Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905 910Gln
Gln Asn Lys Trp Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn 915 920
925Thr Ser Cys Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala
930 935 940Arg Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu
Cys Phe945 950 955 960Leu Leu Arg Leu Ser Arg Ile Gly Gly Val Ile
Gln Asp Thr Leu Pro 965 970 975Val Gln Asn Tyr Lys Thr Lys Glu Gly
Trp Asp Phe His Ser Gln Phe 980 985 990Ile Leu Tyr Cys Leu Glu His
Ser Leu Gln His Leu Leu Tyr Val Tyr 995 1000 1005Leu Asp Cys Tyr
Lys Leu Ser Pro Glu Asn Cys Pro Phe Leu Glu 1010 1015 1020Lys Lys
Glu Leu His Glu Ala His Pro Trp Phe Glu Phe Leu Val 1025 1030
1035Gln Cys Arg Gln Val Ala Ser Asn Leu Thr Asp Pro Lys Leu Ile
1040 1045 1050Phe Gln Ala Ser Leu Ala Asn Ala Gln Ile Leu Ile Pro
Thr Asn 1055 1060 1065Gln Ala Ser Val Ser Ser Met Leu Leu Glu Gly
His Thr Leu Leu 1070 1075 1080Ala Leu Ala Thr Thr Met Tyr Ser Pro
Gly Gly Val Ser Gln Val 1085 1090 1095Val Gln Asn Glu Glu Asn Glu
Asn Cys Leu Lys Lys Val Asp Pro 1100 1105 1110Gln Leu Leu Lys Met
Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr 1115 1120 1125Ala Leu Phe
Pro Gln Cys Thr Pro Pro Ser Val Leu Pro Ser Asp 1130 1135 1140Ile
Thr Ile Tyr His Leu Ile Gln Ser Leu Ser Pro Phe Asp Pro 1145 1150
1155Ser Arg Leu Phe Gly Trp Gln Ser Ala Asn Thr Leu Ala Ile Gly
1160 1165 1170Asp Ala Trp Ser His Leu Pro His Phe Ser Ser Pro Asp
Leu Val
1175 1180 1185Asn Lys Tyr Ala Ile Val Glu Arg Leu Asn Phe Ala Tyr
Tyr Leu 1190 1195 1200His Asn Gly Arg Pro Ser Phe Ala Phe Gly Thr
Phe Leu Val Gln 1205 1210 1215Glu Leu Ile Lys Ser Lys Thr Pro Lys
Gln Leu Ile Gln Gln Val 1220 1225 1230Gly Asn Glu Ala Tyr Val Ile
Gly Leu Ser Ser Phe His Ile Pro 1235 1240 1245Ser Ile Gly Ala Ala
Cys Val Cys Phe Leu Glu Leu Leu Gly Leu 1250 1255 1260Asp Ser Leu
Lys Leu Arg Val Asp Met Lys Val Ala Asn Ile Ile 1265 1270 1275Leu
Ser Tyr Lys Cys Arg Asn Glu Asp Ala Gln Tyr Ser Phe Ile 1280 1285
1290Arg Glu Ser Val Ala Glu Lys Leu Ser Lys Leu Ala Asp Gly Glu
1295 1300 1305Lys Thr Thr Thr Glu Glu Leu Leu Val Leu Leu Glu Glu
Gly Thr 1310 1315 1320Trp Asn Ser Ile Gln Gln Gln Glu Ile Lys Arg
Leu Ser Ser Glu 1325 1330 1335Ser Ser Ser Gln Trp Ala Leu Val Val
Gln Phe Cys Arg Leu His 1340 1345 1350Asn Met Lys Leu Ser Ile Ser
Tyr Leu Arg Glu Cys Ala Lys Ala 1355 1360 1365Asn Asp Trp Leu Gln
Phe Ile Ile His Ser Gln Leu His Asn Tyr 1370 1375 1380His Pro Ala
Glu Val Lys Ser Leu Ile Gln Tyr Phe Ser Pro Val 1385 1390 1395Ile
Gln Asp His Leu Arg Leu Ala Phe Glu Asn Leu Pro Ser Val 1400 1405
1410Pro Thr Ser Lys Met Asp Ser Asp Gln Val Cys Asn Lys Cys Pro
1415 1420 1425Gln Glu Leu Gln Gly Ser Lys Gln Glu Met Thr Asp Leu
Phe Glu 1430 1435 1440Ile Leu Leu Gln Cys Ser Glu Glu Pro Asp Ser
Trp His Trp Leu 1445 1450 1455Leu Val Glu Ala Val Lys Gln Gln Ala
Pro Ile Leu Ser Val Leu 1460 1465 1470Ala Ser Cys Leu Gln Gly Ala
Ser Ala Ile Ser Cys Leu Cys Val 1475 1480 1485Trp Ile Ile Thr Ser
Val Glu Asp Asn Val Ala Thr Glu Ala Met 1490 1495 1500Gly His Ile
Gln Asp Ser Thr Glu Asp His Thr Trp Asn Leu Glu 1505 1510 1515Asp
Leu Ser Val Ile Trp Arg Thr Leu Leu Thr Arg Gln Lys Ser 1520 1525
1530Lys Thr Leu Ile Arg Gly Phe Gln Leu Phe Phe Lys Asp Ser Pro
1535 1540 1545Leu Leu Leu Val Met Glu Met Tyr Glu Leu Cys Met Phe
Phe Arg 1550 1555 1560Asn Tyr Lys Glu Ala Glu Ala Lys Leu Leu Glu
Phe Gln Lys Ser 1565 1570 1575Leu Glu Thr Leu Asn Thr Ala Ala Thr
Lys Val His Pro Val Ile 1580 1585 1590Pro Ala Met Trp Leu Glu Asp
Gln Val Cys Phe Leu Leu Lys Leu 1595 1600 1605Met Leu Gln Gln Cys
Lys Thr Gln Tyr Glu Leu Gly Lys Leu Leu 1610 1615 1620Gln Leu Phe
Val Glu Arg Glu His Leu Phe Ser Asp Gly Pro Asp 1625 1630 1635Val
Lys Lys Leu Cys Ile Leu Cys Gln Ile Leu Lys Asp Thr Ser 1640 1645
1650Ile Ala Ile Asn His Thr Ile Ile Thr Ser Tyr Ser Ile Glu Asn
1655 1660 1665Leu Gln His Glu Cys Arg Ser Ile Leu Glu Arg Leu Gln
Thr Asp 1670 1675 1680Gly Gln Phe Ala Leu Ala Arg Arg Val Ala Glu
Leu Ala Glu Leu 1685 1690 1695Pro Val Asp Asn Leu Val Ile Lys Glu
Ile Thr Gln Glu Met Gln 1700 1705 1710Thr Leu Lys His Ile Glu Gln
Trp Ser Leu Lys Gln Ala Arg Ile 1715 1720 1725Asp Phe Trp Lys Lys
Cys His Glu Asn Phe Lys Lys Asn Ser Ile 1730 1735 1740Ser Ser Lys
Ala Ala Ser Ser Phe Phe Ser Thr Gln Ala His Val 1745 1750 1755Ala
Cys Glu His Pro Thr Gly Trp Ser Ser Met Glu Glu Arg His 1760 1765
1770Leu Leu Leu Thr Leu Ala Gly His Trp Leu Ala Gln Glu Asp Val
1775 1780 1785Val Pro Leu Asp Lys Leu Glu Glu Leu Glu Lys Gln Ile
Trp Leu 1790 1795 1800Cys Arg Ile Thr Gln His Thr Leu Gly Arg Asn
Gln Glu Glu Thr 1805 1810 1815Glu Pro Arg Phe Ser Arg Gln Ile Ser
Thr Ser Gly Glu Leu Ser 1820 1825 1830Phe Asp Ser Leu Ala Ser Glu
Phe Ser Phe Ser Lys Leu Ala Ala 1835 1840 1845Leu Asn Thr Ser Lys
Tyr Leu Glu Leu Asn Ser Leu Pro Ser Lys 1850 1855 1860Glu Thr Cys
Glu Asn Arg Leu Asp Trp Lys Glu Gln Glu Ser Leu 1865 1870 1875Asn
Phe Leu Ile Gly Arg Leu Leu Asp Asp Gly Cys Val His Glu 1880 1885
1890Ala Ser Arg Val Cys Arg Tyr Phe His Phe Tyr Asn Pro Asp Val
1895 1900 1905Ala Leu Val Leu His Cys Arg Ala Leu Ala Ser Gly Glu
Ala Ser 1910 1915 1920Met Glu Asp Leu His Pro Glu Ile His Ala Leu
Leu Gln Ser Ala 1925 1930 1935Glu Leu Leu Glu Glu Glu Ala Pro Asp
Ile Pro Leu Arg Arg Val 1940 1945 1950His Ser Thr Ser Ser Leu Asp
Ser Gln Lys Phe Val Thr Val Pro 1955 1960 1965Ser Ser Asn Glu Val
Val Thr Asn Leu Glu Val Leu Thr Ser Lys 1970 1975 1980Cys Leu His
Gly Lys Asn Tyr Cys Arg Gln Val Leu Cys Leu Tyr 1985 1990 1995Asp
Leu Ala Lys Glu Leu Gly Cys Ser Tyr Thr Asp Val Ala Ala 2000 2005
2010Gln Asp Gly Glu Ala Met Leu Arg Lys Ile Leu Ala Ser Gln Gln
2015 2020 2025Pro Asp Arg Cys Lys Arg Ala Gln Ala Phe Ile Ser Thr
Gln Gly 2030 2035 2040Leu Lys Pro Asp Thr Val Ala Glu Leu Val Ala
Glu Glu Val Thr 2045 2050 2055Arg Glu Leu Leu Thr Ser Ser Gln Gly
Thr Gly His Lys Gln Met 2060 2065 2070Phe Asn Pro Thr Glu Glu Ser
Gln Thr Phe Leu Gln Leu Thr Thr 2075 2080 2085Leu Cys Gln Asp Arg
Thr Leu Val Gly Met Lys Leu Leu Asp Lys 2090 2095 2100Ile Ser Ser
Val Pro His Gly Glu Leu Ser Cys Thr Thr Glu Leu 2105 2110 2115Leu
Ile Leu Ala His His Cys Phe Thr Leu Thr Cys His Met Glu 2120 2125
2130Gly Ile Ile Arg Val Leu Gln Ala Ala His Met Leu Thr Asp Asn
2135 2140 2145His Leu Ala Pro Ser Glu Glu Tyr Gly Leu Val Val Arg
Leu Leu 2150 2155 2160Thr Gly Ile Gly Arg Tyr Asn Glu Met Thr Tyr
Ile Phe Asp Leu 2165 2170 2175Leu His Lys Lys His Tyr Phe Glu Val
Leu Met Arg Lys Lys Leu 2180 2185 2190Asp Pro Ser Gly Thr Leu Lys
Thr Ala Leu Leu Asp Tyr Ile Lys 2195 2200 2205Arg Cys Arg Pro Gly
Asp Ser Glu Lys His Asn Met Ile Ala Leu 2210 2215 2220Cys Phe Ser
Met Cys Arg Glu Ile Gly Glu Asn His Glu Ala Ala 2225 2230 2235Ala
Arg Ile Gln Leu Lys Leu Ile Glu Ser Gln Pro Trp Glu Asp 2240 2245
2250Ser Leu Lys Asp Gly His Gln Leu Lys Gln Leu Leu Leu Lys Ala
2255 2260 2265Leu Thr Leu Met Leu Asp Ala Ala Glu Ser Tyr Ala Lys
Asp Ser 2270 2275 2280Cys Val Arg Gln Ala Gln His Cys Gln Arg Leu
Thr Lys Leu Ile 2285 2290 2295Thr Leu Gln Ile His Phe Leu Asn Thr
Gly Gln Asn Thr Met Leu 2300 2305 2310Ile Asn Leu Gly Arg His Lys
Leu Met Asp Cys Ile Leu Ala Leu 2315 2320 2325Pro Arg Phe Tyr Gln
Ala Ser Ile Val Ala Glu Ala Tyr Asp Phe 2330 2335 2340Val Pro Asp
Trp Ala Glu Ile Leu Tyr Gln Gln Val Ile Leu Lys 2345 2350 2355Gly
Asp Phe Asn Tyr Leu Glu Glu Phe Lys Gln Gln Arg Leu Leu 2360 2365
2370Lys Ser Ser Ile Phe Glu Glu Ile Ser Lys Lys Tyr Lys Gln His
2375 2380 2385Gln Pro Thr Asp Met Val Met Glu Asn Leu Lys Lys Leu
Leu Thr 2390 2395 2400Tyr Cys Glu Asp Val Tyr Leu Tyr Tyr Lys Leu
Ala Tyr Glu His 2405 2410 2415Lys Phe Tyr Glu Ile Val Asn Val Leu
Leu Lys Asp Pro Gln Thr 2420 2425 2430Gly Cys Cys Leu Lys Asp Met
Leu Ala Gly 2435 2440320DNAArtificialprimer 3ccacaggaaa cgaatggaat
20420DNAArtificialprimer 4ggttctgtga ggaaaccacg
20520DNAArtificialprimer 5cagggacatt gtaggccatc
20620DNAArtificialprimer 6ccagttgtaa aattgtgacc
20720DNAArtificialprimer 7tcccagctcc caaaactaaa
20820DNAArtificialprimer 8tcaatcaaca cttctaccac
20922DNAArtificialprimer 9caggttcttt cttgtggcat ca
221025DNAArtificialprimer 10cgaggatatt tttaacctct tatca
251124DNAArtificialprimer 11gttaggcata cttacaaaac tggc
241225DNAArtificialprimer 12cgaggatatt tttaacctct tatca
251320DNAArtificialprimer 13gaacatcttt gccctggttt
201420DNAArtificialprimer 14ctgtgacagg tgttaagtta
201520DNAArtificialprimer 15caggcactga ggcagaagta
201620DNAArtificialprimer 16atctaataca agacagtctc
201726DNAArtificialprimer 17aaaaatcaat tcctaaatca taatcc
261820DNAArtificialprimer 18tagtactgaa gtattgagta
201924DNAArtificialprimer 19tcttttaaag ccaaaaaggg taaa
242020DNAArtificialprimer 20ttaagtaatg ttcttgggca
202121DNAArtificialprimer 21cccaggacta atcatgaagg a
212220DNAArtificialprimer 22atccccaaac cgataaaacc
202321DNAArtificialprimer 23cggtgtgtct tccactagct c
212423DNAArtificialprimer 24gttacataaa tgtataatcc ctg
232520DNAArtificialprimer 25acccagccat tctcagtgtt
202623DNAArtificialprimer 26cattttaaga ctttatggat tac
232720DNAArtificialprimer 27cacagcgaga tcctgtctca
202821DNAArtificialprimer 28cctcactgta agatgatgcc c
212925DNAArtificialprimer 29cctttaaata ctacagtggt gcaga
253020DNAArtificialprimer 30tgtgggcatg atttggtcta
203122DNAArtificialprimer 31ccaactgttg agatggagaa aa
223220DNAArtificialprimer 32acctgctcaa ggacaaatgc
203320DNAArtificialprimer 33tttgaagtat cccagggtgg
203420DNAArtificialprimer 34ccaccattcc ccaaagataa
203520DNAArtificialprimer 35ttacctggat ttggctttgg
203620DNAArtificialprimer 36cctggcttct aaaagtggcc
203722DNAArtificialprimer 37tgcaatccag aaacttgaga ga
223821DNAArtificialprimer 38aagcacaaca tccaaatcct t
213920DNAArtificialprimer 39atgttggcag gaactccatc
204020DNAArtificialprimer 40ctcctttgga gcaacctctg
204120DNAArtificialprimer 41ttccaacagg aaagcacaca
204220DNAArtificialprimer 42caacaggaaa gcacacatgc
204320DNAArtificialprimer 43cagctacttg ggaggctgag
204420DNAArtificialprimer 44gtgtggctgt gacctcactc
204520DNAArtificialprimer 45gcattagaag gggcactgaa
204620DNAArtificialprimer 46aacatggctg ggatgtttct
204720DNAArtificialprimer 47ctcacaacgg tattcacccc
204820DNAArtificialprimer 48ttcctggttg gcctatgatg
204923DNAArtificialprimer 49aagggtttaa gataatttgg gga
235020DNAArtificialprimer 50aatgccaaac acacacctga
205122DNAArtificialprimer 51ggattcttga tactgctttg cc
225220DNAArtificialprimer 52ctcaaagcag aggcaaggag
205320DNAArtificialprimer 53ctgagcccca catttttgtt
205420DNAArtificialprimer 54caagtgctca atagccccat
205525DNAArtificialprimer 55gctaactgcc cttaatagag taaaa
255620DNAArtificialprimer 56aaagggtaca gcgtcagcat
205720DNAArtificialprimer 57cttgccccag attgcataat
205823DNAArtificialprimer 58tccaaaaagt acgtaaaatc cca
235922DNAArtificialprimer 59cagcaaaagg gtaatagcag tg
226020DNAArtificialprimer 60cccaaatgta gtaaatggcg
206123DNAArtificialprimer 61tttgaaagag cagaaagcta tgg
236221DNAArtificialprimer 62tgaaggggtt gtcacacttt t
216322DNAArtificialprimer 63ttgtggcaaa agaaaatttg tg
226420DNAArtificialprimer 64gagaatgcag gctcagttcc
206520DNAArtificialprimer 65atgtggaact gagcctgcat
206623DNAArtificialprimer 66cgacttgcat tttaaagaac ctg
236725DNAArtificialprimer 67ttgtttccag atcatgaaga atatg
256820DNAArtificialprimer 68tcagatagct gaccacagcc
206924DNAArtificialprimer 69tccctcttaa ggagaaaaac actg
247020DNAArtificialprimer 70accgggccga gatataaaat
207125DNAArtificialprimer 71gctagtttgt cttagaacca gaaca
257223DNAArtificialprimer 72ttttgggttg tctcactatc aca
237324DNAArtificialprimer 73aaggaacata gccagttctg tttt
247421DNAArtificialprimer 74tgcgaactat ttttcctttg g
217523DNAArtificialprimer 75tgcaacttct caggtacaca tct
237620DNAArtificialprimer 76aggctagagt gcagtggcat
207720DNAArtificialprimer 77agtcagctta agggaagcgg
207822DNAArtificialprimer 78gaagataacc attttctccc ca
227920DNAArtificialprimer 79ttgtgagtgt ttggggagaa
208021DNAArtificialprimer 80ggggatttag tgaaaacacc a
218124DNAArtificialprimer 81tttgttggag aatacactgt gctt
248225DNAArtificialprimer 82catgtctaca caacagaaag aatgc
258321DNAArtificialprimer 83aaaaggcacc atacagcttt g
218420DNAArtificialprimer 84ggaaacacat gctggaacct
208522DNAArtificialprimer 85cttctgtctg cttcttggtc tt
228622DNAArtificialprimer 86tatcatcatt atctgttgtt gg
228720DNAArtificialprimer 87ttaggtgatc ccactggctc
208820DNAArtificialprimer 88cccaggagtt caaggctgta
208920DNAArtificialprimer 89ctgaggaggg cttgtttttg
209025DNAArtificialprimer 90tctgtaactt gtttactccc agttg
259120DNAArtificialprimer 91gatcacacca ctgcattcca
209220DNAArtificialprimer 92ggcacctgta gtcccagcta
209320DNAArtificialprimer 93tgaggtggga ggatctcttg
209420DNAArtificialprimer 94gatgtgttca gagcagccaa
209520DNAArtificialprimer 95taagctggag gagctggaga
209620DNAArtificialprimer 96ttgttgtccc cttaacttgg
209720DNAArtificialprimer 97caataggcca agggtttcaa
209820DNAArtificialprimer 98tataactcct gctggagggc
209920DNAArtificialprimer 99ggtagcctgg aaattagccc
2010020DNAArtificialprimer 100tgaaccagaa tctgaagcca
2010120DNAArtificialprimer 101ttttgtcctt gggctctttc
2010220DNAArtificialprimer 102cctggttctg tcactagccc
2010320DNAArtificialprimer 103aattagccag ggtggtgaca
2010420DNAArtificialprimer 104cccacaaagg actgatatgg
2010520DNAArtificialprimer 105aaggaccctc agacaggttg
2010620DNAArtificialprimer 106tcctttaagg cagacaaggg
2010724DNAArtificialprimer 107accaggtcaa ctaaactgtt ctct
2410823DNAArtificialprimer 108tatgctgaaa gaccacctgt aga
2310920DNAArtificialprimer 109caggagcagt agtaacacaa
2011020DNAArtificialprimer 110aaagggtaca gcgtcagcat
2011121DNAArtificialprimer 111gcaggtaata agcctgcaga a
2111220DNAArtificialprimer 112cccccttcct agctgctatt
2011325DNAArtificialprimer 113tgttcaaaat agttccatta caaaa
2511422DNAArtificialprimer 114tttcttccaa ggttttcttc ca
2211521DNAArtificialprimer 115tttgcaaaag tgcttgattt t
2111620DNAArtificialprimer 116tgcaggctca gttccacata
2011720DNAArtificialprimer 117ggaatgatgc ctttttctcc
2011820DNAArtificialprimer 118tctcacactt gccttctgga
2011920DNAArtificialprimer 119aatcatcgcc tgagcaaaat
2012020DNAArtificialprimer 120ccagtgactg atccaaagca
2012121DNAArtificialprimer 121ccctcttaag gagaaaaaca c
2112220DNAArtificialprimer 122cagccttatc ctctgctctt
2012320DNAArtificialprimer 123tggaaaaggg gagcagacta
2012421DNAArtificialprimer 124tgcgaactat ttttcctttg g
2112520DNAArtificialprimer 125gaggaggcca caaatcacat
2012620DNAArtificialprimer 126gccttagacc tcgtcacacc
2012723DNAArtificialprimer 127tgctcaggtt ttgacttttt ctc
2312820DNAArtificialprimer 128tttcactgat ggcaagatgc
2012920DNAArtificialprimer 129accaccccca cctctaattc
2013020DNAArtificialprimer 130ctacacaaca gaaagaatgc
2013121DNAArtificialprimer 131ccagctgaaa ctgaaagttg g
2113220DNAArtificialprimer 132ctgggtactt acttcaggct
2013320DNAArtificialprimer 133cactgtgccc tgccttatta
2013420DNAArtificialprimer 134tgtgcctgag taaccgagtg
2013520DNAArtificialprimer 135tcccagattt ggaggttttg
2013624DNAArtificialprimer 136tgcattttaa tttcctaact accc
2413720DNAArtificialprimer 137gctgtagtgg cattttattg
2013820DNAArtificialprimer 138cctgggtgac agagcaagac
2013920DNAArtificialprimer 139agctgcagag ctccataagc
2014020DNAArtificialprimer 140taggcatcca gagcaggaac
2014120DNAArtificialprimer 141ggcatctgaa agcaaccact
2014220DNAArtificialprimer 142ccctccattt tcccaagagt
2014320DNAArtificialprimer 143ggggtgaata ccgttgtgag
2014420DNAArtificialprimer 144acctctgggt tccatgagtg
2014520DNAArtificialprimer 145agactgctcc tctgcactcc
2014621DNAArtificialprimer 146ccgggattgt tcaactttag c
2114720DNAArtificialprimer 147cagtatctta acctgtacat
2014821DNAArtificialprimer 148ccgggattgt tcaactttag c
2114940PRTHomo sapiensmisc_feature(40)..(40)Xaa can be any
naturally occurring amino acid 149Met Ala Ala Glu Glu Gly Val Ala
Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly
Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met
Gly Xaa 35 40150178PRTHomo sapiensmisc_feature(178)..(178)Xaa can
be any naturally occurring amino acid 150Met Ala Ala Glu Glu Gly
Val Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala
Met Gly Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu
Ala Met Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro
Glu Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu
Ser Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75
80Glu Gly Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser
85 90 95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr
Glu 100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys
Asp Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln
Lys Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser
Leu Arg Ile Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu
Phe Ile Asn Lys Cys Val Ile Leu His Ile 165 170 175Ser
Xaa151246PRTHomo sapiensmisc_feature(246)..(246)Xaa can be any
naturally occurring amino acid 151Met Ala Ala Glu Glu Gly Val Ala
Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly
Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met
Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala
Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu
Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly
Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr
Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Val Xaa 245152415PRTHomo
sapiensmisc_feature(415)..(415)Xaa can be any naturally occurring
amino acid 152Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala
Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met
Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser
Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr
Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg
Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe
Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro
Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr
Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu
Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135
140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe
His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val
Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg
Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val
Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe
Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val
Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His
Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250
255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val
260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn
Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg
Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp
Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu
Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln
Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu
Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu
Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375
380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu
Gln385 390 395 400Lys Ile Met Pro Arg Pro Val Ile Gln Glu Asp His
Gly Lys Xaa 405 410 415153412PRTHomo
sapiensmisc_feature(412)..(412)Xaa can be any naturally occurring
amino acid 153Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala
Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met
Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser
Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr
Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg
Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe
Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro
Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr
Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu
Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135
140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe
His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val
Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg
Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val
Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe
Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val
Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His
Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250
255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val
260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn
Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg
Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp
Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu
Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln
Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu
Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu
Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375
380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu
Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Xaa
405 410154556PRTHomo sapiensmisc_feature(556)..(556)Xaa can be any
naturally occurring amino acid 154Met Ala Ala Glu Glu Gly Val Ala
Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly
Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met
Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala
Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu
Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly
Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr
Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys
Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp
Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu
Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu
Leu
Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys
Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn
Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp
Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345
350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His
355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln
Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr
Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro
Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu
Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala
Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr
Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu
Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470
475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly
Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly
Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Ser Ser Gln Trp Leu Gly
Lys Val Leu Asn Ser 515 520 525His Thr Cys Thr Arg Gly Arg Asp Arg
Lys Ser Ser Ala Gly His Ser 530 535 540Lys Phe Leu Phe Glu Glu Gln
Gly Lys Ser Phe Xaa545 550 555155651PRTHomo
sapiensmisc_feature(651)..(651)Xaa can be any naturally occurring
amino acid 155Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala
Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met
Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser
Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr
Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg
Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe
Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro
Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr
Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu
Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135
140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe
His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val
Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg
Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val
Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe
Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val
Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His
Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250
255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val
260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn
Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg
Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp
Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu
Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln
Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu
Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu
Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375
380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu
Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser
Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu
Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr
Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp
Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys
Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470 475 480Cys
Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490
495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser
500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys
Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg
Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn
Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln
Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu
Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg
Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln
Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615
620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly
Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu Leu Xaa 645
650156733PRTHomo sapiensmisc_feature(733)..(733)Xaa can be any
naturally occurring amino acid 156Met Ala Ala Glu Glu Gly Val Ala
Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly
Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met
Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala
Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu
Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly
Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr
Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys
Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp
Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu
Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu
Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys
Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn
Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp
Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345
350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His
355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln
Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr
Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro
Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu
Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala
Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr
Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu
Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470
475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly
Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly
Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp
Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile
Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser
Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val
Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg
Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585
590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu
595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile
Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu
Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu
Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp
Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val
Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val
Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln
Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710
715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Xaa 725
730157953PRTHomo sapiensmisc_feature(953)..(953)Xaa can be any
naturally occurring amino acid 157Met Ala Ala Glu Glu Gly Val Ala
Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly
Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met
Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala
Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu
Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly
Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr
Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys
Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp
Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu
Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu
Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys
Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn
Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp
Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345
350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His
355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln
Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr
Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro
Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu
Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala
Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr
Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu
Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470
475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly
Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly
Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp
Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile
Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser
Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val
Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg
Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585
590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu
595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile
Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu
Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu
Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp
Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val
Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val
Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln
Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710
715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys
Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly
Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr
Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys
Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp
Phe
Val His Gln Val Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe Gln
Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile Lys
Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser 820 825 830Phe
Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg 835 840
845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser
850 855 860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr
Ser Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His
Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe Gln Thr
Gln His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp Pro Leu
Leu Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr Ser Cys Asn Asn
Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg Asn Gly
Gly Phe Phe Gly Ile Xaa945 950158953PRTHomo
sapiensmisc_feature(953)..(953)Xaa can be any naturally occurring
amino acid 158Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala
Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met
Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser
Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr
Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg
Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe
Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro
Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr
Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu
Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135
140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe
His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val
Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg
Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val
Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe
Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val
Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His
Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250
255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val
260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn
Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg
Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp
Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu
Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln
Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu
Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu
Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375
380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu
Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser
Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu
Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr
Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp
Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys
Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470 475 480Cys
Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490
495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser
500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys
Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg
Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn
Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln
Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu
Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg
Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln
Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615
620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly
Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu Leu Arg Thr
Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp Ala Ile Asp
Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val Lys Glu Ser
Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val Ile Ala Ser
Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln Thr Phe Phe
Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710 715 720Leu
Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730
735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val
740 745 750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys
Asn Ile 755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn
Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp Phe Val His
Gln Val Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn
Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln
Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys
Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile
Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855
860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser
Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp
Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln
His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp Pro Leu Leu
Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr Ser Cys Asn Asn Tyr
Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg Asn Gly Val
Phe Phe Gly Ile Xaa945 9501591992PRTHomo
sapiensmisc_feature(1992)..(1992)Xaa can be any naturally occurring
amino acid 159Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala
Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met
Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser
Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr
Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg
Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe
Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro
Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr
Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu
Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135
140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe
His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val
Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg
Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val
Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe
Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val
Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His
Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250
255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val
260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn
Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg
Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp
Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu
Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln
Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu
Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu
Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375
380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu
Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser
Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu
Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr
Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp
Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys
Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470 475 480Cys
Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490
495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser
500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys
Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg
Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn
Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln
Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu
Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg
Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln
Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615
620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly
Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu Leu Arg Thr
Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp Ala Ile Asp
Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val Lys Glu Ser
Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val Ile Ala Ser
Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln Thr Phe Phe
Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710 715 720Leu
Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730
735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val
740 745 750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys
Asn Ile 755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn
Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp Phe Val His
Gln Val Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn
Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln
Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys
Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile
Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855
860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser
Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp
Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln
His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp Pro Leu Leu
Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr Ser Cys Asn Asn Tyr
Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg Asn Gly Val
Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950 955 960Leu
Leu Arg Leu Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu Pro 965 970
975Val Gln Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His Ser Gln Phe
980 985 990Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His Leu Leu Tyr
Val Tyr 995 1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys
Pro Phe Leu Glu 1010 1015 1020Lys Lys Glu Leu His Glu Ala His Pro
Trp Phe Glu Phe Leu Val 1025 1030 1035Gln Cys Arg Gln Val Ala Ser
Asn Leu Thr Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu
Ala Asn Ala Gln Ile Leu Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser
Val Ser Ser Met Leu Leu Glu Gly His Thr Leu Leu 1070 1075 1080Ala
Leu Ala Thr Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val 1085 1090
1095Val Gln Asn Glu Glu Asn Glu Asn Cys Leu Lys Lys Val Asp Pro
1100 1105 1110Gln Leu Leu Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu
Lys Thr 1115 1120 1125Ala Leu Phe Pro Gln Cys Thr Pro Pro Ser Val
Leu Pro Ser Asp 1130 1135 1140Ile Thr Ile Tyr His Leu Ile Gln Ser
Leu Ser Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu Phe Gly Trp Gln
Ser Ala Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp Ala Trp Ser His
Leu Pro His Phe Ser Ser Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr
Ala Ile Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His
Asn Gly Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu Val Gln 1205 1210
1215Glu Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu Ile Gln Gln Val
1220 1225 1230Gly Asn Glu Ala Tyr Val Ile Gly Leu Ser Ser Phe His
Ile Pro 1235 1240 1245Ser Ile Gly Ala Ala Cys Val Cys Phe Leu Glu
Leu Leu Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu Arg Val Asp Met
Lys Val Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr Lys Cys Arg Asn
Glu Asp Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg Glu Ser Val Ala
Glu Lys Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300 1305Lys Thr Thr
Thr Glu Glu Leu Leu Val Leu Leu Glu Glu Gly Thr 1310 1315
1320Trp
Asn Ser Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser Ser Glu 1325 1330
1335Ser Ser Ser Gln Trp Ala Leu Val Val Gln Phe Cys Arg Leu His
1340 1345 1350Asn Met Lys Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala
Lys Ala 1355 1360 1365Asn Asp Trp Leu Gln Phe Ile Ile His Ser Gln
Leu His Asn Tyr 1370 1375 1380His Pro Ala Glu Val Lys Ser Leu Ile
Gln Tyr Phe Ser Pro Val 1385 1390 1395Ile Gln Asp His Leu Arg Leu
Ala Phe Glu Asn Leu Pro Ser Val 1400 1405 1410Pro Thr Ser Lys Met
Asp Ser Asp Gln Val Cys Asn Lys Cys Pro 1415 1420 1425Gln Glu Leu
Gln Gly Ser Lys Gln Glu Met Thr Asp Leu Phe Glu 1430 1435 1440Ile
Leu Leu Gln Cys Ser Glu Glu Pro Asp Ser Trp His Trp Leu 1445 1450
1455Leu Val Glu Ala Val Lys Gln Gln Ala Pro Ile Leu Ser Val Leu
1460 1465 1470Ala Ser Cys Leu Gln Gly Ala Ser Ala Ile Ser Cys Leu
Cys Val 1475 1480 1485Trp Ile Ile Thr Ser Val Glu Asp Asn Val Ala
Thr Glu Ala Met 1490 1495 1500Gly His Ile Gln Asp Ser Thr Glu Asp
His Thr Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser Val Ile Trp Arg
Thr Leu Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys Thr Leu Ile Arg
Gly Phe Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540 1545Leu Leu Leu
Val Met Glu Met Tyr Glu Leu Cys Met Phe Phe Arg 1550 1555 1560Asn
Tyr Lys Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln Lys Ser 1565 1570
1575Leu Glu Thr Leu Asn Thr Ala Ala Thr Lys Val His Pro Val Ile
1580 1585 1590Pro Ala Met Trp Leu Glu Asp Gln Val Cys Phe Leu Leu
Lys Leu 1595 1600 1605Met Leu Gln Gln Cys Lys Thr Gln Tyr Glu Leu
Gly Lys Leu Leu 1610 1615 1620Gln Leu Phe Val Glu Arg Glu His Leu
Phe Ser Asp Gly Pro Asp 1625 1630 1635Val Lys Lys Leu Cys Ile Leu
Cys Gln Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile Ala Ile Asn His
Thr Ile Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660 1665Leu Gln His
Glu Cys Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp 1670 1675 1680Gly
Gln Phe Ala Leu Ala Arg Arg Val Ala Glu Leu Ala Glu Leu 1685 1690
1695Pro Val Asp Asn Leu Val Ile Lys Glu Ile Thr Gln Glu Met Gln
1700 1705 1710Thr Leu Lys His Ile Glu Gln Trp Ser Leu Lys Gln Ala
Arg Ile 1715 1720 1725Asp Phe Trp Lys Lys Cys His Glu Asn Phe Lys
Lys Asn Ser Ile 1730 1735 1740Ser Ser Lys Ala Ala Ser Ser Phe Phe
Ser Thr Gln Ala His Val 1745 1750 1755Ala Cys Glu His Pro Thr Gly
Trp Ser Ser Met Glu Glu Arg His 1760 1765 1770Leu Leu Leu Thr Leu
Ala Gly His Trp Leu Ala Gln Glu Asp Val 1775 1780 1785Val Pro Leu
Asp Lys Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu 1790 1795 1800Cys
Arg Ile Thr Gln His Thr Leu Gly Arg Asn Gln Glu Glu Thr 1805 1810
1815Glu Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser Gly Glu Leu Ser
1820 1825 1830Phe Asp Ser Leu Ala Ser Glu Phe Ser Phe Ser Lys Leu
Ala Ala 1835 1840 1845Leu Asn Thr Ser Lys Tyr Leu Glu Leu Asn Ser
Leu Pro Ser Lys 1850 1855 1860Glu Thr Cys Glu Asn Arg Leu Asp Trp
Lys Glu Gln Glu Ser Leu 1865 1870 1875Asn Phe Leu Ile Gly Arg Leu
Leu Asp Asp Gly Cys Val His Glu 1880 1885 1890Ala Ser Arg Val Cys
Arg Tyr Phe His Phe Tyr Asn Pro Asp Val 1895 1900 1905Ala Leu Val
Leu His Cys Arg Ala Leu Ala Ser Gly Glu Ala Ser 1910 1915 1920Met
Glu Asp Leu His Pro Glu Ile His Ala Leu Leu Gln Ser Ala 1925 1930
1935Glu Leu Leu Glu Glu Glu Ala Pro Asp Ile Pro Leu Arg Arg Val
1940 1945 1950His Ser Thr Ser Ser Leu Asp Ser Gln Lys Phe Val Thr
Val Pro 1955 1960 1965Ser Ser Asn Glu Val Val Thr Asn Leu Glu Val
Leu Thr Ser Lys 1970 1975 1980Cys Leu His Gly Lys Asn Tyr Cys Xaa
1985 19901602034PRTHomo sapiensmisc_feature(2034)..(2034)Xaa can be
any naturally occurring amino acid 160Met Ala Ala Glu Glu Gly Val
Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met
Gly Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala
Met Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu
Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser
Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu
Gly Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90
95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu
100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp
Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys
Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu
Arg Ile Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe
Ile Asn Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg
Asp Ala Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu
Pro Ala Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys
Arg Gly Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215
220Phe Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala
Leu225 230 235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu
Pro Ala Lys Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln
Asp Leu Asp Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala
Val Ala Leu Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly
His Leu Leu Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln
Gly Pro Lys Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser
Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330
335Ser Trp Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser
340 345 350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile
Leu His 355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser
Val Gln Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly
Gln Tyr Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser
Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln
Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe
Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr
Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455
460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln
Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile
Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met
Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu
Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu
Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe
Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys
Ser Ser Val Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr 565 570
575Leu Arg Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser
580 585 590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe
Ser Glu 595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn
Gln Ile Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu Asp Glu
His Leu Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile
Asn Glu Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu
Thr Asp Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro
Lys Val Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu
Glu Val Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695
700Gln Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu
Glu705 710 715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn
Leu Lys Lys Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys
Asn Met Gly Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile Cys
Phe Tyr Thr Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val Glu
Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg
Thr Ile Asp Phe Val His Gln Val Glu Lys Leu Tyr785 790 795 800Leu
Gly His Phe Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810
815Trp Ile Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser
820 825 830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp
His Arg 835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu
Thr Gln Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu
Tyr Lys Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu
Thr Ala Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly
Glu Phe Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn
Lys Trp Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr
Ser Cys Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935
940Arg Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu Cys
Phe945 950 955 960Leu Leu Arg Leu Ser Arg Ile Gly Gly Val Ile Gln
Asp Thr Leu Pro 965 970 975Val Gln Asn Tyr Lys Thr Lys Glu Gly Trp
Asp Phe His Ser Gln Phe 980 985 990Ile Leu Tyr Cys Leu Glu His Ser
Leu Gln His Leu Leu Tyr Val Tyr 995 1000 1005Leu Asp Cys Tyr Lys
Leu Ser Pro Glu Asn Cys Pro Phe Leu Glu 1010 1015 1020Lys Lys Glu
Leu His Glu Ala His Pro Trp Phe Glu Phe Leu Val 1025 1030 1035Gln
Cys Arg Gln Val Ala Ser Asn Leu Thr Asp Pro Lys Leu Ile 1040 1045
1050Phe Gln Ala Ser Leu Ala Asn Ala Gln Ile Leu Ile Pro Thr Asn
1055 1060 1065Gln Ala Ser Val Ser Ser Met Leu Leu Glu Gly His Thr
Leu Leu 1070 1075 1080Ala Leu Ala Thr Thr Met Tyr Ser Pro Gly Gly
Val Ser Gln Val 1085 1090 1095Val Gln Asn Glu Glu Asn Glu Asn Cys
Leu Lys Lys Val Asp Pro 1100 1105 1110Gln Leu Leu Lys Met Ala Leu
Thr Pro Tyr Pro Lys Leu Lys Thr 1115 1120 1125Ala Leu Phe Pro Gln
Cys Thr Pro Pro Ser Val Leu Pro Ser Asp 1130 1135 1140Ile Thr Ile
Tyr His Leu Ile Gln Ser Leu Ser Pro Phe Asp Pro 1145 1150 1155Ser
Arg Leu Phe Gly Trp Gln Ser Ala Asn Thr Leu Ala Ile Gly 1160 1165
1170Asp Ala Trp Ser His Leu Pro His Phe Ser Ser Pro Asp Leu Val
1175 1180 1185Asn Lys Tyr Ala Ile Val Glu Arg Leu Asn Phe Ala Tyr
Tyr Leu 1190 1195 1200His Asn Gly Arg Pro Ser Phe Ala Phe Gly Thr
Phe Leu Val Gln 1205 1210 1215Glu Leu Ile Lys Ser Lys Thr Pro Lys
Gln Leu Ile Gln Gln Val 1220 1225 1230Gly Asn Glu Ala Tyr Val Ile
Gly Leu Ser Ser Phe His Ile Pro 1235 1240 1245Ser Ile Gly Ala Ala
Cys Val Cys Phe Leu Glu Leu Leu Gly Leu 1250 1255 1260Asp Ser Leu
Lys Leu Arg Val Asp Met Lys Val Ala Asn Ile Ile 1265 1270 1275Leu
Ser Tyr Lys Cys Arg Asn Glu Asp Ala Gln Tyr Ser Phe Ile 1280 1285
1290Arg Glu Ser Val Ala Glu Lys Leu Ser Lys Leu Ala Asp Gly Glu
1295 1300 1305Lys Thr Thr Thr Glu Glu Leu Leu Val Leu Leu Glu Glu
Gly Thr 1310 1315 1320Trp Asn Ser Ile Gln Gln Gln Glu Ile Lys Arg
Leu Ser Ser Glu 1325 1330 1335Ser Ser Ser Gln Trp Ala Leu Val Val
Gln Phe Cys Arg Leu His 1340 1345 1350Asn Met Lys Leu Ser Ile Ser
Tyr Leu Arg Glu Cys Ala Lys Ala 1355 1360 1365Asn Asp Trp Leu Gln
Phe Ile Ile His Ser Gln Leu His Asn Tyr 1370 1375 1380His Pro Ala
Glu Val Lys Ser Leu Ile Gln Tyr Phe Ser Pro Val 1385 1390 1395Ile
Gln Asp His Leu Arg Leu Ala Phe Glu Asn Leu Pro Ser Val 1400 1405
1410Pro Thr Ser Lys Met Asp Ser Asp Gln Val Cys Asn Lys Cys Pro
1415 1420 1425Gln Glu Leu Gln Gly Ser Lys Gln Glu Met Thr Asp Leu
Phe Glu 1430 1435 1440Ile Leu Leu Gln Cys Ser Glu Glu Pro Asp Ser
Trp His Trp Leu 1445 1450 1455Leu Val Glu Ala Val Lys Gln Gln Ala
Pro Ile Leu Ser Val Leu 1460 1465 1470Ala Ser Cys Leu Gln Gly Ala
Ser Ala Ile Ser Cys Leu Cys Val 1475 1480 1485Trp Ile Ile Thr Ser
Val Glu Asp Asn Val Ala Thr Glu Ala Met 1490 1495 1500Gly His Ile
Gln Asp Ser Thr Glu Asp His Thr Trp Asn Leu Glu 1505 1510 1515Asp
Leu Ser Val Ile Trp Arg Thr Leu Leu Thr Arg Gln Lys Ser 1520 1525
1530Lys Thr Leu Ile Arg Gly Phe Gln Leu Phe Phe Lys Asp Ser Pro
1535 1540 1545Leu Leu Leu Val Met Glu Met Tyr Glu Leu Cys Met Phe
Phe Arg 1550 1555 1560Asn Tyr Lys Glu Ala Glu Ala Lys Leu Leu Glu
Phe Gln Lys Ser 1565 1570 1575Leu Glu Thr Leu Asn Thr Ala Ala Thr
Lys Val His Pro Val Ile 1580 1585 1590Pro Ala Met Trp Leu Glu Asp
Gln Val Cys Phe Leu Leu Lys Leu 1595 1600 1605Met Leu Gln Gln Cys
Lys Thr Gln Tyr Glu Leu Gly Lys Leu Leu 1610 1615 1620Gln Leu Phe
Val Glu Arg Glu His Leu Phe Ser Asp Gly Pro Asp 1625 1630 1635Val
Lys Lys Leu Cys Ile Leu Cys Gln Ile Leu Lys Asp Thr Ser 1640 1645
1650Ile Ala Ile Asn His Thr Ile Ile Thr Ser Tyr Ser Ile Glu Asn
1655 1660 1665Leu Gln His Glu Cys Arg Ser Ile Leu Glu Arg Leu Gln
Thr Asp 1670 1675 1680Gly Gln Phe Ala Leu Ala Arg Arg Val Ala Glu
Leu Ala Glu Leu 1685 1690 1695Pro Val Asp Asn Leu Val Ile Lys Glu
Ile Thr Gln Glu Met Gln 1700 1705 1710Thr Leu Lys His Ile Glu Gln
Trp Ser Leu Lys Gln Ala Arg Ile 1715 1720 1725Asp Phe Trp Lys Lys
Cys His Glu Asn Phe Lys Lys Asn Ser Ile 1730 1735 1740Ser Ser Lys
Ala Ala Ser Ser Phe Phe Ser Thr Gln Ala His Val 1745 1750 1755Ala
Cys Glu His Pro Thr Gly Trp Ser Ser Met Glu Glu Arg His
1760 1765 1770Leu Leu Leu Thr Leu Ala Gly His Trp Leu Ala Gln Glu
Asp Val 1775 1780 1785Val Pro Leu Asp Lys Leu Glu Glu Leu Glu Lys
Gln Ile Trp Leu 1790 1795 1800Cys Arg Ile Thr Gln His Thr Leu Gly
Arg Asn Gln Glu Glu Thr 1805 1810 1815Glu Pro Arg Phe Ser Arg Gln
Ile Ser Thr Ser Gly Glu Leu Ser 1820 1825 1830Phe Asp Ser Leu Ala
Ser Glu Phe Ser Phe Ser Lys Leu Ala Ala 1835 1840 1845Leu Asn Thr
Ser Lys Tyr Leu Glu Leu Asn Ser Leu Pro Ser Lys 1850 1855 1860Glu
Thr Cys Glu Asn Arg Leu Asp Trp Lys Glu Gln Glu Ser Leu 1865 1870
1875Asn Phe Leu Ile Gly Arg Leu Leu Asp Asp Gly Cys Val His Glu
1880 1885 1890Ala Ser Arg Val Cys Arg Tyr Phe His Phe Tyr Asn Pro
Asp Val 1895 1900 1905Ala Leu Val Leu His Cys Arg Ala Leu Ala Ser
Gly Glu Ala Ser 1910 1915 1920Met Glu Asp Leu His Pro Glu Ile His
Ala Leu Leu Gln Ser Ala 1925 1930 1935Glu Leu Leu Glu Glu Glu Ala
Pro Asp Ile Pro Leu Arg Arg Val 1940 1945 1950His Ser Thr Ser Ser
Leu Asp Ser Gln Lys Phe Val Thr Val Pro 1955 1960 1965Ser Ser Asn
Glu Val Val Thr Asn Leu Glu Val Leu Thr Ser Lys 1970 1975 1980Cys
Leu His Gly Lys Asn Tyr Cys Arg Gln Val Leu Cys Leu Tyr 1985 1990
1995Asp Leu Ala Lys Glu Leu Gly Cys Ser Tyr Thr Asp Val Ala Ala
2000 2005 2010Gln Asp Gly Glu Ala Met Leu Arg Lys Ile Leu Ala Ser
Gln Gln 2015 2020 2025Pro Asp Arg Cys Lys Xaa 20301612172PRTHomo
sapiensmisc_feature(2172)..(2172)Xaa can be any naturally occurring
amino acid 161Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala
Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met
Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser
Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr
Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg
Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe
Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro
Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr
Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu
Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135
140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe
His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val
Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg
Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val
Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe
Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val
Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His
Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250
255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val
260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn
Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg
Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp
Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu
Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln
Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu
Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu
Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375
380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu
Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser
Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu
Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr
Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp
Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys
Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470 475 480Cys
Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490
495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser
500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys
Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg
Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn
Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln
Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu
Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg
Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln
Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615
620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly
Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu Leu Arg Thr
Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp Ala Ile Asp
Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val Lys Glu Ser
Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val Ile Ala Ser
Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln Thr Phe Phe
Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710 715 720Leu
Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730
735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val
740 745 750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys
Asn Ile 755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn
Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp Phe Val His
Gln Val Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn
Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln
Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys
Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile
Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855
860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser
Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp
Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln
His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp Pro Leu Leu
Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr Ser Cys Asn Asn Tyr
Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg Asn Gly Val
Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950 955 960Leu
Leu Arg Leu Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu Pro 965 970
975Val Gln Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His Ser Gln Phe
980 985 990Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His Leu Leu Tyr
Val Tyr 995 1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys
Pro Phe Leu Glu 1010 1015 1020Lys Lys Glu Leu His Glu Ala His Pro
Trp Phe Glu Phe Leu Val 1025 1030 1035Gln Cys Arg Gln Val Ala Ser
Asn Leu Thr Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu
Ala Asn Ala Gln Ile Leu Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser
Val Ser Ser Met Leu Leu Glu Gly His Thr Leu Leu 1070 1075 1080Ala
Leu Ala Thr Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val 1085 1090
1095Val Gln Asn Glu Glu Asn Glu Asn Cys Leu Lys Lys Val Asp Pro
1100 1105 1110Gln Leu Leu Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu
Lys Thr 1115 1120 1125Ala Leu Phe Pro Gln Cys Thr Pro Pro Ser Val
Leu Pro Ser Asp 1130 1135 1140Ile Thr Ile Tyr His Leu Ile Gln Ser
Leu Ser Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu Phe Gly Trp Gln
Ser Ala Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp Ala Trp Ser His
Leu Pro His Phe Ser Ser Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr
Ala Ile Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His
Asn Gly Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu Val Gln 1205 1210
1215Glu Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu Ile Gln Gln Val
1220 1225 1230Gly Asn Glu Ala Tyr Val Ile Gly Leu Ser Ser Phe His
Ile Pro 1235 1240 1245Ser Ile Gly Ala Ala Cys Val Cys Phe Leu Glu
Leu Leu Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu Arg Val Asp Met
Lys Val Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr Lys Cys Arg Asn
Glu Asp Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg Glu Ser Val Ala
Glu Lys Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300 1305Lys Thr Thr
Thr Glu Glu Leu Leu Val Leu Leu Glu Glu Gly Thr 1310 1315 1320Trp
Asn Ser Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser Ser Glu 1325 1330
1335Ser Ser Ser Gln Trp Ala Leu Val Val Gln Phe Cys Arg Leu His
1340 1345 1350Asn Met Lys Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala
Lys Ala 1355 1360 1365Asn Asp Trp Leu Gln Phe Ile Ile His Ser Gln
Leu His Asn Tyr 1370 1375 1380His Pro Ala Glu Val Lys Ser Leu Ile
Gln Tyr Phe Ser Pro Val 1385 1390 1395Ile Gln Asp His Leu Arg Leu
Ala Phe Glu Asn Leu Pro Ser Val 1400 1405 1410Pro Thr Ser Lys Met
Asp Ser Asp Gln Val Cys Asn Lys Cys Pro 1415 1420 1425Gln Glu Leu
Gln Gly Ser Lys Gln Glu Met Thr Asp Leu Phe Glu 1430 1435 1440Ile
Leu Leu Gln Cys Ser Glu Glu Pro Asp Ser Trp His Trp Leu 1445 1450
1455Leu Val Glu Ala Val Lys Gln Gln Ala Pro Ile Leu Ser Val Leu
1460 1465 1470Ala Ser Cys Leu Gln Gly Ala Ser Ala Ile Ser Cys Leu
Cys Val 1475 1480 1485Trp Ile Ile Thr Ser Val Glu Asp Asn Val Ala
Thr Glu Ala Met 1490 1495 1500Gly His Ile Gln Asp Ser Thr Glu Asp
His Thr Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser Val Ile Trp Arg
Thr Leu Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys Thr Leu Ile Arg
Gly Phe Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540 1545Leu Leu Leu
Val Met Glu Met Tyr Glu Leu Cys Met Phe Phe Arg 1550 1555 1560Asn
Tyr Lys Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln Lys Ser 1565 1570
1575Leu Glu Thr Leu Asn Thr Ala Ala Thr Lys Val His Pro Val Ile
1580 1585 1590Pro Ala Met Trp Leu Glu Asp Gln Val Cys Phe Leu Leu
Lys Leu 1595 1600 1605Met Leu Gln Gln Cys Lys Thr Gln Tyr Glu Leu
Gly Lys Leu Leu 1610 1615 1620Gln Leu Phe Val Glu Arg Glu His Leu
Phe Ser Asp Gly Pro Asp 1625 1630 1635Val Lys Lys Leu Cys Ile Leu
Cys Gln Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile Ala Ile Asn His
Thr Ile Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660 1665Leu Gln His
Glu Cys Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp 1670 1675 1680Gly
Gln Phe Ala Leu Ala Arg Arg Val Ala Glu Leu Ala Glu Leu 1685 1690
1695Pro Val Asp Asn Leu Val Ile Lys Glu Ile Thr Gln Glu Met Gln
1700 1705 1710Thr Leu Lys His Ile Glu Gln Trp Ser Leu Lys Gln Ala
Arg Ile 1715 1720 1725Asp Phe Trp Lys Lys Cys His Glu Asn Phe Lys
Lys Asn Ser Ile 1730 1735 1740Ser Ser Lys Ala Ala Ser Ser Phe Phe
Ser Thr Gln Ala His Val 1745 1750 1755Ala Cys Glu His Pro Thr Gly
Trp Ser Ser Met Glu Glu Arg His 1760 1765 1770Leu Leu Leu Thr Leu
Ala Gly His Trp Leu Ala Gln Glu Asp Val 1775 1780 1785Val Pro Leu
Asp Lys Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu 1790 1795 1800Cys
Arg Ile Thr Gln His Thr Leu Gly Arg Asn Gln Glu Glu Thr 1805 1810
1815Glu Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser Gly Glu Leu Ser
1820 1825 1830Phe Asp Ser Leu Ala Ser Glu Phe Ser Phe Ser Lys Leu
Ala Ala 1835 1840 1845Leu Asn Thr Ser Lys Tyr Leu Glu Leu Asn Ser
Leu Pro Ser Lys 1850 1855 1860Glu Thr Cys Glu Asn Arg Leu Asp Trp
Lys Glu Gln Glu Ser Leu 1865 1870 1875Asn Phe Leu Ile Gly Arg Leu
Leu Asp Asp Gly Cys Val His Glu 1880 1885 1890Ala Ser Arg Val Cys
Arg Tyr Phe His Phe Tyr Asn Pro Asp Val 1895 1900 1905Ala Leu Val
Leu His Cys Arg Ala Leu Ala Ser Gly Glu Ala Ser 1910 1915 1920Met
Glu Asp Leu His Pro Glu Ile His Ala Leu Leu Gln Ser Ala 1925 1930
1935Glu Leu Leu Glu Glu Glu Ala Pro Asp Ile Pro Leu Arg Arg Val
1940 1945 1950His Ser Thr Ser Ser Leu Asp Ser Gln Lys Phe Val Thr
Val Pro 1955 1960 1965Ser Ser Asn Glu Val Val Thr Asn Leu Glu Val
Leu Thr Ser Lys 1970 1975 1980Cys Leu His Gly Lys Asn Tyr Cys Arg
Gln Val Leu Cys Leu Tyr 1985 1990 1995Asp Leu Ala Lys Glu Leu Gly
Cys Ser Tyr Thr Asp Val Ala Ala 2000 2005 2010Gln Asp Gly Glu Ala
Met Leu Arg Lys Ile Leu Ala Ser Gln Gln 2015 2020 2025Pro Asp Arg
Cys Lys Arg Ala Gln Ala Phe Ile Ser Thr Gln Gly 2030 2035 2040Leu
Lys Pro Asp Thr Val Ala Glu Leu Val Ala Glu Glu Val Thr 2045 2050
2055Arg Glu Leu Leu Thr Ser Ser Gln Gly Thr Gly His Lys Gln Met
2060 2065 2070Phe Asn Pro Thr Glu Glu Ser Gln Thr Phe Leu Gln Leu
Thr Thr 2075 2080 2085Leu Cys Gln Asp Arg Thr Leu Val Gly Met Lys
Leu Leu Asp Lys 2090 2095 2100Ile Ser Ser Val Pro His Gly Glu Leu
Ser Cys Thr Thr Glu Leu 2105 2110 2115Leu Ile Leu Ala His His Cys
Phe Thr Leu Thr Cys His Met Glu 2120 2125 2130Gly Ile Ile Arg Val
Leu Gln Ala Ala His Met Leu Thr Asp Asn 2135 2140 2145His Leu Pro
Pro Val Arg Ser Met Gly Trp Trp Tyr Gly Ser Ser 2150 2155 2160Leu
Ala Leu Glu Gly Thr Thr Arg Xaa
2165 21701622260PRTHomo sapiensmisc_feature(2260)..(2260)Xaa can be
any naturally occurring amino acid 162Met Ala Ala Glu Glu Gly Val
Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met
Gly Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala
Met Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu
Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser
Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu
Gly Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90
95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu
100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp
Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys
Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu
Arg Ile Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe
Ile Asn Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg
Asp Ala Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu
Pro Ala Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys
Arg Gly Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215
220Phe Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala
Leu225 230 235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu
Pro Ala Lys Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln
Asp Leu Asp Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala
Val Ala Leu Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly
His Leu Leu Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln
Gly Pro Lys Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser
Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330
335Ser Trp Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser
340 345 350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile
Leu His 355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser
Val Gln Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly
Gln Tyr Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser
Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln
Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe
Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr
Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455
460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln
Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile
Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met
Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu
Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu
Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe
Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys
Ser Ser Val Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr 565 570
575Leu Arg Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser
580 585 590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe
Ser Glu 595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn
Gln Ile Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu Asp Glu
His Leu Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile
Asn Glu Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu
Thr Asp Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro
Lys Val Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu
Glu Val Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695
700Gln Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu
Glu705 710 715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn
Leu Lys Lys Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys
Asn Met Gly Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile Cys
Phe Tyr Thr Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val Glu
Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg
Thr Ile Asp Phe Val His Gln Val Glu Lys Leu Tyr785 790 795 800Leu
Gly His Phe Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810
815Trp Ile Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser
820 825 830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp
His Arg 835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu
Thr Gln Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu
Tyr Lys Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu
Thr Ala Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly
Glu Phe Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn
Lys Trp Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr
Ser Cys Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935
940Arg Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu Cys
Phe945 950 955 960Leu Leu Arg Leu Ser Arg Ile Gly Gly Val Ile Gln
Asp Thr Leu Pro 965 970 975Val Gln Asn Tyr Lys Thr Lys Glu Gly Trp
Asp Phe His Ser Gln Phe 980 985 990Ile Leu Tyr Cys Leu Glu His Ser
Leu Gln His Leu Leu Tyr Val Tyr 995 1000 1005Leu Asp Cys Tyr Lys
Leu Ser Pro Glu Asn Cys Pro Phe Leu Glu 1010 1015 1020Lys Lys Glu
Leu His Glu Ala His Pro Trp Phe Glu Phe Leu Val 1025 1030 1035Gln
Cys Arg Gln Val Ala Ser Asn Leu Thr Asp Pro Lys Leu Ile 1040 1045
1050Phe Gln Ala Ser Leu Ala Asn Ala Gln Ile Leu Ile Pro Thr Asn
1055 1060 1065Gln Ala Ser Val Ser Ser Met Leu Leu Glu Gly His Thr
Leu Leu 1070 1075 1080Ala Leu Ala Thr Thr Met Tyr Ser Pro Gly Gly
Val Ser Gln Val 1085 1090 1095Val Gln Asn Glu Glu Asn Glu Asn Cys
Leu Lys Lys Val Asp Pro 1100 1105 1110Gln Leu Leu Lys Met Ala Leu
Thr Pro Tyr Pro Lys Leu Lys Thr 1115 1120 1125Ala Leu Phe Pro Gln
Cys Thr Pro Pro Ser Val Leu Pro Ser Asp 1130 1135 1140Ile Thr Ile
Tyr His Leu Ile Gln Ser Leu Ser Pro Phe Asp Pro 1145 1150 1155Ser
Arg Leu Phe Gly Trp Gln Ser Ala Asn Thr Leu Ala Ile Gly 1160 1165
1170Asp Ala Trp Ser His Leu Pro His Phe Ser Ser Pro Asp Leu Val
1175 1180 1185Asn Lys Tyr Ala Ile Val Glu Arg Leu Asn Phe Ala Tyr
Tyr Leu 1190 1195 1200His Asn Gly Arg Pro Ser Phe Ala Phe Gly Thr
Phe Leu Val Gln 1205 1210 1215Glu Leu Ile Lys Ser Lys Thr Pro Lys
Gln Leu Ile Gln Gln Val 1220 1225 1230Gly Asn Glu Ala Tyr Val Ile
Gly Leu Ser Ser Phe His Ile Pro 1235 1240 1245Ser Ile Gly Ala Ala
Cys Val Cys Phe Leu Glu Leu Leu Gly Leu 1250 1255 1260Asp Ser Leu
Lys Leu Arg Val Asp Met Lys Val Ala Asn Ile Ile 1265 1270 1275Leu
Ser Tyr Lys Cys Arg Asn Glu Asp Ala Gln Tyr Ser Phe Ile 1280 1285
1290Arg Glu Ser Val Ala Glu Lys Leu Ser Lys Leu Ala Asp Gly Glu
1295 1300 1305Lys Thr Thr Thr Glu Glu Leu Leu Val Leu Leu Glu Glu
Gly Thr 1310 1315 1320Trp Asn Ser Ile Gln Gln Gln Glu Ile Lys Arg
Leu Ser Ser Glu 1325 1330 1335Ser Ser Ser Gln Trp Ala Leu Val Val
Gln Phe Cys Arg Leu His 1340 1345 1350Asn Met Lys Leu Ser Ile Ser
Tyr Leu Arg Glu Cys Ala Lys Ala 1355 1360 1365Asn Asp Trp Leu Gln
Phe Ile Ile His Ser Gln Leu His Asn Tyr 1370 1375 1380His Pro Ala
Glu Val Lys Ser Leu Ile Gln Tyr Phe Ser Pro Val 1385 1390 1395Ile
Gln Asp His Leu Arg Leu Ala Phe Glu Asn Leu Pro Ser Val 1400 1405
1410Pro Thr Ser Lys Met Asp Ser Asp Gln Val Cys Asn Lys Cys Pro
1415 1420 1425Gln Glu Leu Gln Gly Ser Lys Gln Glu Met Thr Asp Leu
Phe Glu 1430 1435 1440Ile Leu Leu Gln Cys Ser Glu Glu Pro Asp Ser
Trp His Trp Leu 1445 1450 1455Leu Val Glu Ala Val Lys Gln Gln Ala
Pro Ile Leu Ser Val Leu 1460 1465 1470Ala Ser Cys Leu Gln Gly Ala
Ser Ala Ile Ser Cys Leu Cys Val 1475 1480 1485Trp Ile Ile Thr Ser
Val Glu Asp Asn Val Ala Thr Glu Ala Met 1490 1495 1500Gly His Ile
Gln Asp Ser Thr Glu Asp His Thr Trp Asn Leu Glu 1505 1510 1515Asp
Leu Ser Val Ile Trp Arg Thr Leu Leu Thr Arg Gln Lys Ser 1520 1525
1530Lys Thr Leu Ile Arg Gly Phe Gln Leu Phe Phe Lys Asp Ser Pro
1535 1540 1545Leu Leu Leu Val Met Glu Met Tyr Glu Leu Cys Met Phe
Phe Arg 1550 1555 1560Asn Tyr Lys Glu Ala Glu Ala Lys Leu Leu Glu
Phe Gln Lys Ser 1565 1570 1575Leu Glu Thr Leu Asn Thr Ala Ala Thr
Lys Val His Pro Val Ile 1580 1585 1590Pro Ala Met Trp Leu Glu Asp
Gln Val Cys Phe Leu Leu Lys Leu 1595 1600 1605Met Leu Gln Gln Cys
Lys Thr Gln Tyr Glu Leu Gly Lys Leu Leu 1610 1615 1620Gln Leu Phe
Val Glu Arg Glu His Leu Phe Ser Asp Gly Pro Asp 1625 1630 1635Val
Lys Lys Leu Cys Ile Leu Cys Gln Ile Leu Lys Asp Thr Ser 1640 1645
1650Ile Ala Ile Asn His Thr Ile Ile Thr Ser Tyr Ser Ile Glu Asn
1655 1660 1665Leu Gln His Glu Cys Arg Ser Ile Leu Glu Arg Leu Gln
Thr Asp 1670 1675 1680Gly Gln Phe Ala Leu Ala Arg Arg Val Ala Glu
Leu Ala Glu Leu 1685 1690 1695Pro Val Asp Asn Leu Val Ile Lys Glu
Ile Thr Gln Glu Met Gln 1700 1705 1710Thr Leu Lys His Ile Glu Gln
Trp Ser Leu Lys Gln Ala Arg Ile 1715 1720 1725Asp Phe Trp Lys Lys
Cys His Glu Asn Phe Lys Lys Asn Ser Ile 1730 1735 1740Ser Ser Lys
Ala Ala Ser Ser Phe Phe Ser Thr Gln Ala His Val 1745 1750 1755Ala
Cys Glu His Pro Thr Gly Trp Ser Ser Met Glu Glu Arg His 1760 1765
1770Leu Leu Leu Thr Leu Ala Gly His Trp Leu Ala Gln Glu Asp Val
1775 1780 1785Val Pro Leu Asp Lys Leu Glu Glu Leu Glu Lys Gln Ile
Trp Leu 1790 1795 1800Cys Arg Ile Thr Gln His Thr Leu Gly Arg Asn
Gln Glu Glu Thr 1805 1810 1815Glu Pro Arg Phe Ser Arg Gln Ile Ser
Thr Ser Gly Glu Leu Ser 1820 1825 1830Phe Asp Ser Leu Ala Ser Glu
Phe Ser Phe Ser Lys Leu Ala Ala 1835 1840 1845Leu Asn Thr Ser Lys
Tyr Leu Glu Leu Asn Ser Leu Pro Ser Lys 1850 1855 1860Glu Thr Cys
Glu Asn Arg Leu Asp Trp Lys Glu Gln Glu Ser Leu 1865 1870 1875Asn
Phe Leu Ile Gly Arg Leu Leu Asp Asp Gly Cys Val His Glu 1880 1885
1890Ala Ser Arg Val Cys Arg Tyr Phe His Phe Tyr Asn Pro Asp Val
1895 1900 1905Ala Leu Val Leu His Cys Arg Ala Leu Ala Ser Gly Glu
Ala Ser 1910 1915 1920Met Glu Asp Leu His Pro Glu Ile His Ala Leu
Leu Gln Ser Ala 1925 1930 1935Glu Leu Leu Glu Glu Glu Ala Pro Asp
Ile Pro Leu Arg Arg Val 1940 1945 1950His Ser Thr Ser Ser Leu Asp
Ser Gln Lys Phe Val Thr Val Pro 1955 1960 1965Ser Ser Asn Glu Val
Val Thr Asn Leu Glu Val Leu Thr Ser Lys 1970 1975 1980Cys Leu His
Gly Lys Asn Tyr Cys Arg Gln Val Leu Cys Leu Tyr 1985 1990 1995Asp
Leu Ala Lys Glu Leu Gly Cys Ser Tyr Thr Asp Val Ala Ala 2000 2005
2010Gln Asp Gly Glu Ala Met Leu Arg Lys Ile Leu Ala Ser Gln Gln
2015 2020 2025Pro Asp Arg Cys Lys Arg Ala Gln Ala Phe Ile Ser Thr
Gln Gly 2030 2035 2040Leu Lys Pro Asp Thr Val Ala Glu Leu Val Ala
Glu Glu Val Thr 2045 2050 2055Arg Glu Leu Leu Thr Ser Ser Gln Gly
Thr Gly His Lys Gln Met 2060 2065 2070Phe Asn Pro Thr Glu Glu Ser
Gln Thr Phe Leu Gln Leu Thr Thr 2075 2080 2085Leu Cys Gln Asp Arg
Thr Leu Val Gly Met Lys Leu Leu Asp Lys 2090 2095 2100Ile Ser Ser
Val Pro His Gly Glu Leu Ser Cys Thr Thr Glu Leu 2105 2110 2115Leu
Ile Leu Ala His His Cys Phe Thr Leu Thr Cys His Met Glu 2120 2125
2130Gly Ile Ile Arg Val Leu Gln Ala Ala His Met Leu Thr Asp Asn
2135 2140 2145His Leu Ala Pro Ser Glu Glu Tyr Gly Leu Val Val Arg
Leu Leu 2150 2155 2160Thr Gly Ile Gly Arg Tyr Asn Glu Met Thr Tyr
Ile Phe Asp Leu 2165 2170 2175Leu His Lys Lys His Tyr Phe Glu Val
Leu Met Arg Lys Lys Leu 2180 2185 2190Asp Pro Ser Gly Thr Leu Lys
Thr Ala Leu Leu Asp Tyr Ile Lys 2195 2200 2205Arg Cys Arg Pro Gly
Asp Ser Glu Lys His Asn Met Ile Ala Leu 2210 2215 2220Cys Phe Ser
Met Cys Arg Glu Ile Gly Glu Asn His Glu Ala Ala 2225 2230 2235Ala
Arg Ile Gln Leu Lys Leu Ser Leu Ser Pro Gly Arg Thr Ala 2240 2245
2250Ser Arg Met Gly Thr Ser Xaa 2255 22601632338PRTHomo
sapiensmisc_feature(2338)..(2338)Xaa can be any naturally occurring
amino acid 163Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala
Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met
Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser
Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr
Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg
Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe
Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro
Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr
Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu
Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135
140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe
His145 150
155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val Ile Leu His
Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg Val Leu Asn
Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val Asp Met Ile
Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe Val Leu Ser
Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val Asp Gly Thr
Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His Lys Glu Asp
Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250 255Ser Ser
Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val 260 265
270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn Leu Tyr
275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg Ile Leu
Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp Glu Asp
Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu Ala Lys
Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln Leu Ser
Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu Val Ser
Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu Glu Ser
Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375 380Ala
Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu Gln385 390
395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile
Met 405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys
Val Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr Trp Glu Val
Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp Leu Glu Thr
Gln Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys Cys Ile Pro
Val Asp Ser Ser Gly Asp Gln Gln Leu465 470 475 480Cys Phe Val Leu
Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490 495Thr Gln
Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser 500 505
510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys Ser Ile
515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg Gln Leu
Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn Leu Phe
Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln Phe Asp
His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu Glu Leu
Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg Glu Ser
Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln Leu Leu
Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615 620Leu
Phe Ile His Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly Val625 630
635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile
Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp
Val His Glu 660 665 670Asn Val Pro Lys Val Lys Glu Ser Asn Ile Trp
Lys Lys Leu Ser Phe 675 680 685Glu Glu Val Ile Ala Ser Ala Ile Leu
Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln Thr Phe Phe Arg Ile Asp
Ser His Ser Ala Gln Lys Leu Glu Glu705 710 715 720Leu Ile Gly Ile
Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730 735Asn Ile
Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val 740 745
750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys Asn Ile
755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn Tyr Phe
Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp Phe Val His Gln Val
Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn Met Gln
Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln Asp Phe
Phe Lys His Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys Tyr Asp
Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile Val Leu
Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855 860Ile
Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser Pro865 870
875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp Trp Leu Asn
Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln His Ser Tyr
Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp Pro Leu Leu Thr Val Asp
Val Ile Asn Gln Asn 915 920 925Thr Ser Cys Asn Asn Tyr Met Arg Asn
Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg Asn Gly Val Phe Leu Ala
Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950 955 960Leu Leu Arg Leu
Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu Pro 965 970 975Val Gln
Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His Ser Gln Phe 980 985
990Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His Leu Leu Tyr Val Tyr
995 1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys Pro Phe
Leu Glu 1010 1015 1020Lys Lys Glu Leu His Glu Ala His Pro Trp Phe
Glu Phe Leu Val 1025 1030 1035Gln Cys Arg Gln Val Ala Ser Asn Leu
Thr Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu Ala Asn
Ala Gln Ile Leu Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser Val Ser
Ser Met Leu Leu Glu Gly His Thr Leu Leu 1070 1075 1080Ala Leu Ala
Thr Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val 1085 1090 1095Val
Gln Asn Glu Glu Asn Glu Asn Cys Leu Lys Lys Val Asp Pro 1100 1105
1110Gln Leu Leu Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr
1115 1120 1125Ala Leu Phe Pro Gln Cys Thr Pro Pro Ser Val Leu Pro
Ser Asp 1130 1135 1140Ile Thr Ile Tyr His Leu Ile Gln Ser Leu Ser
Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu Phe Gly Trp Gln Ser Ala
Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp Ala Trp Ser His Leu Pro
His Phe Ser Ser Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr Ala Ile
Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His Asn Gly
Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu Val Gln 1205 1210 1215Glu
Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu Ile Gln Gln Val 1220 1225
1230Gly Asn Glu Ala Tyr Val Ile Gly Leu Ser Ser Phe His Ile Pro
1235 1240 1245Ser Ile Gly Ala Ala Cys Val Cys Phe Leu Glu Leu Leu
Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu Arg Val Asp Met Lys Val
Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr Lys Cys Arg Asn Glu Asp
Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg Glu Ser Val Ala Glu Lys
Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300 1305Lys Thr Thr Thr Glu
Glu Leu Leu Val Leu Leu Glu Glu Gly Thr 1310 1315 1320Trp Asn Ser
Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser Ser Glu 1325 1330 1335Ser
Ser Ser Gln Trp Ala Leu Val Val Gln Phe Cys Arg Leu His 1340 1345
1350Asn Met Lys Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala Lys Ala
1355 1360 1365Asn Asp Trp Leu Gln Phe Ile Ile His Ser Gln Leu His
Asn Tyr 1370 1375 1380His Pro Ala Glu Val Lys Ser Leu Ile Gln Tyr
Phe Ser Pro Val 1385 1390 1395Ile Gln Asp His Leu Arg Leu Ala Phe
Glu Asn Leu Pro Ser Val 1400 1405 1410Pro Thr Ser Lys Met Asp Ser
Asp Gln Val Cys Asn Lys Cys Pro 1415 1420 1425Gln Glu Leu Gln Gly
Ser Lys Gln Glu Met Thr Asp Leu Phe Glu 1430 1435 1440Ile Leu Leu
Gln Cys Ser Glu Glu Pro Asp Ser Trp His Trp Leu 1445 1450 1455Leu
Val Glu Ala Val Lys Gln Gln Ala Pro Ile Leu Ser Val Leu 1460 1465
1470Ala Ser Cys Leu Gln Gly Ala Ser Ala Ile Ser Cys Leu Cys Val
1475 1480 1485Trp Ile Ile Thr Ser Val Glu Asp Asn Val Ala Thr Glu
Ala Met 1490 1495 1500Gly His Ile Gln Asp Ser Thr Glu Asp His Thr
Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser Val Ile Trp Arg Thr Leu
Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys Thr Leu Ile Arg Gly Phe
Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540 1545Leu Leu Leu Val Met
Glu Met Tyr Glu Leu Cys Met Phe Phe Arg 1550 1555 1560Asn Tyr Lys
Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln Lys Ser 1565 1570 1575Leu
Glu Thr Leu Asn Thr Ala Ala Thr Lys Val His Pro Val Ile 1580 1585
1590Pro Ala Met Trp Leu Glu Asp Gln Val Cys Phe Leu Leu Lys Leu
1595 1600 1605Met Leu Gln Gln Cys Lys Thr Gln Tyr Glu Leu Gly Lys
Leu Leu 1610 1615 1620Gln Leu Phe Val Glu Arg Glu His Leu Phe Ser
Asp Gly Pro Asp 1625 1630 1635Val Lys Lys Leu Cys Ile Leu Cys Gln
Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile Ala Ile Asn His Thr Ile
Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660 1665Leu Gln His Glu Cys
Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp 1670 1675 1680Gly Gln Phe
Ala Leu Ala Arg Arg Val Ala Glu Leu Ala Glu Leu 1685 1690 1695Pro
Val Asp Asn Leu Val Ile Lys Glu Ile Thr Gln Glu Met Gln 1700 1705
1710Thr Leu Lys His Ile Glu Gln Trp Ser Leu Lys Gln Ala Arg Ile
1715 1720 1725Asp Phe Trp Lys Lys Cys His Glu Asn Phe Lys Lys Asn
Ser Ile 1730 1735 1740Ser Ser Lys Ala Ala Ser Ser Phe Phe Ser Thr
Gln Ala His Val 1745 1750 1755Ala Cys Glu His Pro Thr Gly Trp Ser
Ser Met Glu Glu Arg His 1760 1765 1770Leu Leu Leu Thr Leu Ala Gly
His Trp Leu Ala Gln Glu Asp Val 1775 1780 1785Val Pro Leu Asp Lys
Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu 1790 1795 1800Cys Arg Ile
Thr Gln His Thr Leu Gly Arg Asn Gln Glu Glu Thr 1805 1810 1815Glu
Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser Gly Glu Leu Ser 1820 1825
1830Phe Asp Ser Leu Ala Ser Glu Phe Ser Phe Ser Lys Leu Ala Ala
1835 1840 1845Leu Asn Thr Ser Lys Tyr Leu Glu Leu Asn Ser Leu Pro
Ser Lys 1850 1855 1860Glu Thr Cys Glu Asn Arg Leu Asp Trp Lys Glu
Gln Glu Ser Leu 1865 1870 1875Asn Phe Leu Ile Gly Arg Leu Leu Asp
Asp Gly Cys Val His Glu 1880 1885 1890Ala Ser Arg Val Cys Arg Tyr
Phe His Phe Tyr Asn Pro Asp Val 1895 1900 1905Ala Leu Val Leu His
Cys Arg Ala Leu Ala Ser Gly Glu Ala Ser 1910 1915 1920Met Glu Asp
Leu His Pro Glu Ile His Ala Leu Leu Gln Ser Ala 1925 1930 1935Glu
Leu Leu Glu Glu Glu Ala Pro Asp Ile Pro Leu Arg Arg Val 1940 1945
1950His Ser Thr Ser Ser Leu Asp Ser Gln Lys Phe Val Thr Val Pro
1955 1960 1965Ser Ser Asn Glu Val Val Thr Asn Leu Glu Val Leu Thr
Ser Lys 1970 1975 1980Cys Leu His Gly Lys Asn Tyr Cys Arg Gln Val
Leu Cys Leu Tyr 1985 1990 1995Asp Leu Ala Lys Glu Leu Gly Cys Ser
Tyr Thr Asp Val Ala Ala 2000 2005 2010Gln Asp Gly Glu Ala Met Leu
Arg Lys Ile Leu Ala Ser Gln Gln 2015 2020 2025Pro Asp Arg Cys Lys
Arg Ala Gln Ala Phe Ile Ser Thr Gln Gly 2030 2035 2040Leu Lys Pro
Asp Thr Val Ala Glu Leu Val Ala Glu Glu Val Thr 2045 2050 2055Arg
Glu Leu Leu Thr Ser Ser Gln Gly Thr Gly His Lys Gln Met 2060 2065
2070Phe Asn Pro Thr Glu Glu Ser Gln Thr Phe Leu Gln Leu Thr Thr
2075 2080 2085Leu Cys Gln Asp Arg Thr Leu Val Gly Met Lys Leu Leu
Asp Lys 2090 2095 2100Ile Ser Ser Val Pro His Gly Glu Leu Ser Cys
Thr Thr Glu Leu 2105 2110 2115Leu Ile Leu Ala His His Cys Phe Thr
Leu Thr Cys His Met Glu 2120 2125 2130Gly Ile Ile Arg Val Leu Gln
Ala Ala His Met Leu Thr Asp Asn 2135 2140 2145His Leu Ala Pro Ser
Glu Glu Tyr Gly Leu Val Val Arg Leu Leu 2150 2155 2160Thr Gly Ile
Gly Arg Tyr Asn Glu Met Thr Tyr Ile Phe Asp Leu 2165 2170 2175Leu
His Lys Lys His Tyr Phe Glu Val Leu Met Arg Lys Lys Leu 2180 2185
2190Asp Pro Ser Gly Thr Leu Lys Thr Ala Leu Leu Asp Tyr Ile Lys
2195 2200 2205Arg Cys Arg Pro Gly Asp Ser Glu Lys His Asn Met Ile
Ala Leu 2210 2215 2220Cys Phe Ser Met Cys Arg Glu Ile Gly Glu Asn
His Glu Ala Ala 2225 2230 2235Ala Arg Ile Gln Leu Lys Leu Ile Glu
Ser Gln Pro Trp Glu Asp 2240 2245 2250Ser Leu Lys Asp Gly His Gln
Leu Lys Gln Leu Leu Leu Lys Ala 2255 2260 2265Leu Thr Leu Met Leu
Asp Ala Ala Glu Leu Cys Gln Gly Leu Leu 2270 2275 2280Cys Ala Thr
Gly Pro Ala Leu Ser Ala Ala His Gln Val Asp Asn 2285 2290 2295Ser
Ala Asp Ser Leu Ser Glu His Trp Pro Glu His Asn Ala His 2300 2305
2310Gln Leu Gly Pro Pro Gln Ala Asp Gly Leu Tyr Ser Gly Pro Thr
2315 2320 2325Ser Val Leu Pro Gly Phe Tyr Cys Gly Xaa 2330
23351642349PRTHomo sapiensmisc_feature(2349)..(2349)Xaa can be any
naturally occurring amino acid 164Met Ala Ala Glu Glu Gly Val Ala
Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly
Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met
Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala
Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu
Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly
Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr
Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys
Ile 245 250
255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val
260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn
Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg
Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp
Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu
Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln
Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu
Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu
Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375
380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu
Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser
Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu
Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr
Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp
Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys
Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470 475 480Cys
Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490
495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser
500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys
Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg
Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn
Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln
Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu
Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg
Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln
Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615
620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly
Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu Leu Arg Thr
Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp Ala Ile Asp
Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val Lys Glu Ser
Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val Ile Ala Ser
Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln Thr Phe Phe
Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710 715 720Leu
Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730
735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val
740 745 750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys
Asn Ile 755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn
Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp Phe Val His
Gln Val Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn
Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln
Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys
Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile
Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855
860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser
Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp
Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln
His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp Pro Leu Leu
Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr Ser Cys Asn Asn Tyr
Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg Asn Gly Val
Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950 955 960Leu
Leu Arg Leu Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu Pro 965 970
975Val Gln Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His Ser Gln Phe
980 985 990Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His Leu Leu Tyr
Val Tyr 995 1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys
Pro Phe Leu Glu 1010 1015 1020Lys Lys Glu Leu His Glu Ala His Pro
Trp Phe Glu Phe Leu Val 1025 1030 1035Gln Cys Arg Gln Val Ala Ser
Asn Leu Thr Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu
Ala Asn Ala Gln Ile Leu Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser
Val Ser Ser Met Leu Leu Glu Gly His Thr Leu Leu 1070 1075 1080Ala
Leu Ala Thr Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val 1085 1090
1095Val Gln Asn Glu Glu Asn Glu Asn Cys Leu Lys Lys Val Asp Pro
1100 1105 1110Gln Leu Leu Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu
Lys Thr 1115 1120 1125Ala Leu Phe Pro Gln Cys Thr Pro Pro Ser Val
Leu Pro Ser Asp 1130 1135 1140Ile Thr Ile Tyr His Leu Ile Gln Ser
Leu Ser Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu Phe Gly Trp Gln
Ser Ala Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp Ala Trp Ser His
Leu Pro His Phe Ser Ser Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr
Ala Ile Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His
Asn Gly Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu Val Gln 1205 1210
1215Glu Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu Ile Gln Gln Val
1220 1225 1230Gly Asn Glu Ala Tyr Val Ile Gly Leu Ser Ser Phe His
Ile Pro 1235 1240 1245Ser Ile Gly Ala Ala Cys Val Cys Phe Leu Glu
Leu Leu Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu Arg Val Asp Met
Lys Val Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr Lys Cys Arg Asn
Glu Asp Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg Glu Ser Val Ala
Glu Lys Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300 1305Lys Thr Thr
Thr Glu Glu Leu Leu Val Leu Leu Glu Glu Gly Thr 1310 1315 1320Trp
Asn Ser Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser Ser Glu 1325 1330
1335Ser Ser Ser Gln Trp Ala Leu Val Val Gln Phe Cys Arg Leu His
1340 1345 1350Asn Met Lys Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala
Lys Ala 1355 1360 1365Asn Asp Trp Leu Gln Phe Ile Ile His Ser Gln
Leu His Asn Tyr 1370 1375 1380His Pro Ala Glu Val Lys Ser Leu Ile
Gln Tyr Phe Ser Pro Val 1385 1390 1395Ile Gln Asp His Leu Arg Leu
Ala Phe Glu Asn Leu Pro Ser Val 1400 1405 1410Pro Thr Ser Lys Met
Asp Ser Asp Gln Val Cys Asn Lys Cys Pro 1415 1420 1425Gln Glu Leu
Gln Gly Ser Lys Gln Glu Met Thr Asp Leu Phe Glu 1430 1435 1440Ile
Leu Leu Gln Cys Ser Glu Glu Pro Asp Ser Trp His Trp Leu 1445 1450
1455Leu Val Glu Ala Val Lys Gln Gln Ala Pro Ile Leu Ser Val Leu
1460 1465 1470Ala Ser Cys Leu Gln Gly Ala Ser Ala Ile Ser Cys Leu
Cys Val 1475 1480 1485Trp Ile Ile Thr Ser Val Glu Asp Asn Val Ala
Thr Glu Ala Met 1490 1495 1500Gly His Ile Gln Asp Ser Thr Glu Asp
His Thr Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser Val Ile Trp Arg
Thr Leu Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys Thr Leu Ile Arg
Gly Phe Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540 1545Leu Leu Leu
Val Met Glu Met Tyr Glu Leu Cys Met Phe Phe Arg 1550 1555 1560Asn
Tyr Lys Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln Lys Ser 1565 1570
1575Leu Glu Thr Leu Asn Thr Ala Ala Thr Lys Val His Pro Val Ile
1580 1585 1590Pro Ala Met Trp Leu Glu Asp Gln Val Cys Phe Leu Leu
Lys Leu 1595 1600 1605Met Leu Gln Gln Cys Lys Thr Gln Tyr Glu Leu
Gly Lys Leu Leu 1610 1615 1620Gln Leu Phe Val Glu Arg Glu His Leu
Phe Ser Asp Gly Pro Asp 1625 1630 1635Val Lys Lys Leu Cys Ile Leu
Cys Gln Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile Ala Ile Asn His
Thr Ile Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660 1665Leu Gln His
Glu Cys Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp 1670 1675 1680Gly
Gln Phe Ala Leu Ala Arg Arg Val Ala Glu Leu Ala Glu Leu 1685 1690
1695Pro Val Asp Asn Leu Val Ile Lys Glu Ile Thr Gln Glu Met Gln
1700 1705 1710Thr Leu Lys His Ile Glu Gln Trp Ser Leu Lys Gln Ala
Arg Ile 1715 1720 1725Asp Phe Trp Lys Lys Cys His Glu Asn Phe Lys
Lys Asn Ser Ile 1730 1735 1740Ser Ser Lys Ala Ala Ser Ser Phe Phe
Ser Thr Gln Ala His Val 1745 1750 1755Ala Cys Glu His Pro Thr Gly
Trp Ser Ser Met Glu Glu Arg His 1760 1765 1770Leu Leu Leu Thr Leu
Ala Gly His Trp Leu Ala Gln Glu Asp Val 1775 1780 1785Val Pro Leu
Asp Lys Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu 1790 1795 1800Cys
Arg Ile Thr Gln His Thr Leu Gly Arg Asn Gln Glu Glu Thr 1805 1810
1815Glu Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser Gly Glu Leu Ser
1820 1825 1830Phe Asp Ser Leu Ala Ser Glu Phe Ser Phe Ser Lys Leu
Ala Ala 1835 1840 1845Leu Asn Thr Ser Lys Tyr Leu Glu Leu Asn Ser
Leu Pro Ser Lys 1850 1855 1860Glu Thr Cys Glu Asn Arg Leu Asp Trp
Lys Glu Gln Glu Ser Leu 1865 1870 1875Asn Phe Leu Ile Gly Arg Leu
Leu Asp Asp Gly Cys Val His Glu 1880 1885 1890Ala Ser Arg Val Cys
Arg Tyr Phe His Phe Tyr Asn Pro Asp Val 1895 1900 1905Ala Leu Val
Leu His Cys Arg Ala Leu Ala Ser Gly Glu Ala Ser 1910 1915 1920Met
Glu Asp Leu His Pro Glu Ile His Ala Leu Leu Gln Ser Ala 1925 1930
1935Glu Leu Leu Glu Glu Glu Ala Pro Asp Ile Pro Leu Arg Arg Val
1940 1945 1950His Ser Thr Ser Ser Leu Asp Ser Gln Lys Phe Val Thr
Val Pro 1955 1960 1965Ser Ser Asn Glu Val Val Thr Asn Leu Glu Val
Leu Thr Ser Lys 1970 1975 1980Cys Leu His Gly Lys Asn Tyr Cys Arg
Gln Val Leu Cys Leu Tyr 1985 1990 1995Asp Leu Ala Lys Glu Leu Gly
Cys Ser Tyr Thr Asp Val Ala Ala 2000 2005 2010Gln Asp Gly Glu Ala
Met Leu Arg Lys Ile Leu Ala Ser Gln Gln 2015 2020 2025Pro Asp Arg
Cys Lys Arg Ala Gln Ala Phe Ile Ser Thr Gln Gly 2030 2035 2040Leu
Lys Pro Asp Thr Val Ala Glu Leu Val Ala Glu Glu Val Thr 2045 2050
2055Arg Glu Leu Leu Thr Ser Ser Gln Gly Thr Gly His Lys Gln Met
2060 2065 2070Phe Asn Pro Thr Glu Glu Ser Gln Thr Phe Leu Gln Leu
Thr Thr 2075 2080 2085Leu Cys Gln Asp Arg Thr Leu Val Gly Met Lys
Leu Leu Asp Lys 2090 2095 2100Ile Ser Ser Val Pro His Gly Glu Leu
Ser Cys Thr Thr Glu Leu 2105 2110 2115Leu Ile Leu Ala His His Cys
Phe Thr Leu Thr Cys His Met Glu 2120 2125 2130Gly Ile Ile Arg Val
Leu Gln Ala Ala His Met Leu Thr Asp Asn 2135 2140 2145His Leu Ala
Pro Ser Glu Glu Tyr Gly Leu Val Val Arg Leu Leu 2150 2155 2160Thr
Gly Ile Gly Arg Tyr Asn Glu Met Thr Tyr Ile Phe Asp Leu 2165 2170
2175Leu His Lys Lys His Tyr Phe Glu Val Leu Met Arg Lys Lys Leu
2180 2185 2190Asp Pro Ser Gly Thr Leu Lys Thr Ala Leu Leu Asp Tyr
Ile Lys 2195 2200 2205Arg Cys Arg Pro Gly Asp Ser Glu Lys His Asn
Met Ile Ala Leu 2210 2215 2220Cys Phe Ser Met Cys Arg Glu Ile Gly
Glu Asn His Glu Ala Ala 2225 2230 2235Ala Arg Ile Gln Leu Lys Leu
Ile Glu Ser Gln Pro Trp Glu Asp 2240 2245 2250Ser Leu Lys Asp Gly
His Gln Leu Lys Gln Leu Leu Leu Lys Ala 2255 2260 2265Leu Thr Leu
Met Leu Asp Ala Ala Glu Ser Tyr Ala Lys Asp Ser 2270 2275 2280Cys
Val Arg Gln Ala Gln His Cys Gln Arg Leu Thr Lys Leu Ile 2285 2290
2295Thr Leu Gln Ile His Phe Leu Asn Thr Gly Gln Asn Thr Met Leu
2300 2305 2310Ile Asn Leu Gly Arg His Lys Leu Met Asp Cys Ile Leu
Ala Leu 2315 2320 2325Pro Arg Phe Tyr Gln Ala Ser Ile Val Ala Glu
Ala Tyr Asp Phe 2330 2335 2340Cys Ser Arg Leu Gly Xaa
23451652443PRThomo sapiens 165Met Ala Ala Glu Glu Gly Val Ala Ser
Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg
Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly
Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu
Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr
Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro
Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro
Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys
Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp
Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu
Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu
Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys
Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn
Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp
Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345
350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe
Gln Asp Ile Leu His 355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His
Ser Thr Ser Val Gln Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile
Met His Gly Gln Tyr Asn Val Leu Gln385 390 395 400Lys Asp His Ala
Lys Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile
Ser Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val 420 425
430Thr Gly Phe Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr
435 440 445Thr Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys
Ser Ser 450 455 460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly
Asp Gln Gln Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu
Ser Leu Ile Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn
Arg Leu Met Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp Thr Leu
Cys His Leu Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro Ile His
Ala Leu Glu Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535 540Val
Asn Phe Phe Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550
555 560Lys Ser Ser Val Ser Asp Gln Phe Asp His Leu Ser Ser His Leu
Tyr 565 570 575Leu Arg Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu
Leu Cys Ser 580 585 590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser
Lys His Phe Ser Glu 595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe
Leu Asn Asn Gln Ile Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu
Leu Asp Glu His Leu Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr
Ser Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro
Trp Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp Val His Glu 660 665
670Asn Val Pro Lys Val Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe
675 680 685Glu Glu Val Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro
Glu Ala 690 695 700Gln Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln
Lys Leu Glu Glu705 710 715 720Leu Ile Gly Ile Gly Leu Asn Leu Val
Phe Asp Asn Leu Lys Lys Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu
Leu Leu Lys Asn Met Gly Phe Asp Val 740 745 750Lys Gly Gln Leu Leu
Lys Ile Cys Phe Tyr Thr Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe
Leu Val Glu Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys
Glu Lys Arg Thr Ile Asp Phe Val His Gln Val Glu Lys Leu Tyr785 790
795 800Leu Gly His Phe Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg
Tyr 805 810 815Trp Ile Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val
Leu Asp Ser 820 825 830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn
Lys Gln Asp His Arg 835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp
Asp Gln Leu Thr Gln Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser
Pro Glu Glu Tyr Lys Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp
Arg Tyr Leu Thr Ala Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu
Trp Ile Gly Glu Phe Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905
910Gln Gln Asn Lys Trp Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn
915 920 925Thr Ser Cys Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys
Leu Ala 930 935 940Gly Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp
Phe Glu Cys Phe945 950 955 960Leu Leu Arg Leu Ser Arg Ile Gly Gly
Val Ile Gln Asp Thr Leu Pro 965 970 975Val Gln Asn Tyr Lys Thr Lys
Glu Gly Trp Asp Phe His Ser Gln Phe 980 985 990Ile Leu Tyr Cys Leu
Glu His Ser Leu Gln His Leu Leu Tyr Val Tyr 995 1000 1005Leu Asp
Cys Tyr Lys Leu Ser Pro Glu Asn Cys Pro Phe Leu Glu 1010 1015
1020Lys Lys Glu Leu His Glu Ala His Pro Trp Phe Glu Phe Leu Val
1025 1030 1035Gln Cys Arg Gln Val Ala Ser Asn Leu Thr Asp Pro Lys
Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu Ala Asn Ala Gln Ile Leu
Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser Val Ser Ser Met Leu Leu
Glu Gly His Thr Leu Leu 1070 1075 1080Ala Leu Ala Thr Thr Met Tyr
Ser Pro Gly Gly Val Ser Gln Val 1085 1090 1095Val Gln Asn Glu Glu
Asn Glu Asn Cys Leu Lys Lys Val Asp Pro 1100 1105 1110Gln Leu Leu
Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr 1115 1120 1125Ala
Leu Phe Pro Gln Cys Thr Pro Pro Ser Val Leu Pro Ser Asp 1130 1135
1140Ile Thr Ile Tyr His Leu Ile Gln Ser Leu Ser Pro Phe Asp Pro
1145 1150 1155Ser Arg Leu Phe Gly Trp Gln Ser Ala Asn Thr Leu Ala
Ile Gly 1160 1165 1170Asp Ala Trp Ser His Leu Pro His Phe Ser Ser
Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr Ala Ile Val Glu Arg Leu
Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His Asn Gly Arg Pro Ser Phe
Ala Phe Gly Thr Phe Leu Val Gln 1205 1210 1215Glu Leu Ile Lys Ser
Lys Thr Pro Lys Gln Leu Ile Gln Gln Val 1220 1225 1230Gly Asn Glu
Ala Tyr Val Ile Gly Leu Ser Ser Phe His Ile Pro 1235 1240 1245Ser
Ile Gly Ala Ala Cys Val Cys Phe Leu Glu Leu Leu Gly Leu 1250 1255
1260Asp Ser Leu Lys Leu Arg Val Asp Met Lys Val Ala Asn Ile Ile
1265 1270 1275Leu Ser Tyr Lys Cys Arg Asn Glu Asp Ala Gln Tyr Ser
Phe Ile 1280 1285 1290Arg Glu Ser Val Ala Glu Lys Leu Ser Lys Leu
Ala Asp Gly Glu 1295 1300 1305Lys Thr Thr Thr Glu Glu Leu Leu Val
Leu Leu Glu Glu Gly Thr 1310 1315 1320Trp Asn Ser Ile Gln Gln Gln
Glu Ile Lys Arg Leu Ser Ser Glu 1325 1330 1335Ser Ser Ser Gln Trp
Ala Leu Val Val Gln Phe Cys Arg Leu His 1340 1345 1350Asn Met Lys
Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala Lys Ala 1355 1360 1365Asn
Asp Trp Leu Gln Phe Ile Ile His Ser Gln Leu His Asn Tyr 1370 1375
1380His Pro Ala Glu Val Lys Ser Leu Ile Gln Tyr Phe Ser Pro Val
1385 1390 1395Ile Gln Asp His Leu Arg Leu Ala Phe Glu Asn Leu Pro
Ser Val 1400 1405 1410Pro Thr Ser Lys Met Asp Ser Asp Gln Val Cys
Asn Lys Cys Pro 1415 1420 1425Gln Glu Leu Gln Gly Ser Lys Gln Glu
Met Thr Asp Leu Phe Glu 1430 1435 1440Ile Leu Leu Gln Cys Ser Glu
Glu Pro Asp Ser Trp His Trp Leu 1445 1450 1455Leu Val Glu Ala Val
Lys Gln Gln Ala Pro Ile Leu Ser Val Leu 1460 1465 1470Ala Ser Cys
Leu Gln Gly Ala Ser Ala Ile Ser Cys Leu Cys Val 1475 1480 1485Trp
Ile Ile Thr Ser Val Glu Asp Asn Val Ala Thr Glu Ala Met 1490 1495
1500Gly His Ile Gln Asp Ser Thr Glu Asp His Thr Trp Asn Leu Glu
1505 1510 1515Asp Leu Ser Val Ile Trp Arg Thr Leu Leu Thr Arg Gln
Lys Ser 1520 1525 1530Lys Thr Leu Ile Arg Gly Phe Gln Leu Phe Phe
Lys Asp Ser Pro 1535 1540 1545Leu Leu Leu Val Met Glu Met Tyr Glu
Leu Cys Met Phe Phe Arg 1550 1555 1560Asn Tyr Lys Glu Ala Glu Ala
Lys Leu Leu Glu Phe Gln Lys Ser 1565 1570 1575Leu Glu Thr Leu Asn
Thr Ala Ala Thr Lys Val His Pro Val Ile 1580 1585 1590Pro Ala Met
Trp Leu Glu Asp Gln Val Cys Phe Leu Leu Lys Leu 1595 1600 1605Met
Leu Gln Gln Cys Lys Thr Gln Tyr Glu Leu Gly Lys Leu Leu 1610 1615
1620Gln Leu Phe Val Glu Arg Glu His Leu Phe Ser Asp Gly Pro Asp
1625 1630 1635Val Lys Lys Leu Cys Ile Leu Cys Gln Ile Leu Lys Asp
Thr Ser 1640 1645 1650Ile Ala Ile Asn His Thr Ile Ile Thr Ser Tyr
Ser Ile Glu Asn 1655 1660 1665Leu Gln His Glu Cys Arg Ser Ile Leu
Glu Arg Leu Gln Thr Asp 1670 1675 1680Gly Gln Phe Ala Leu Ala Arg
Arg Val Ala Glu Leu Ala Glu Leu 1685 1690 1695Pro Val Asp Asn Leu
Val Ile Lys Glu Ile Thr Gln Glu Met Gln 1700 1705 1710Thr Leu Lys
His Ile Glu Gln Trp Ser Leu Lys Gln Ala Arg Ile 1715 1720 1725Asp
Phe Trp Lys Lys Cys His Glu Asn Phe Lys Lys Asn Ser Ile 1730 1735
1740Ser Ser Lys Ala Ala Ser Ser Phe Phe Ser Thr Gln Ala His Val
1745 1750 1755Ala Cys Glu His Pro Thr Gly Trp Ser Ser Met Glu Glu
Arg His 1760 1765 1770Leu Leu Leu Thr Leu Ala Gly His Trp Leu Ala
Gln Glu Asp Val 1775 1780 1785Val Pro Leu Asp Lys Leu Glu Glu Leu
Glu Lys Gln Ile Trp Leu 1790 1795 1800Cys Arg Ile Thr Gln His Thr
Leu Gly Arg Asn Gln Glu Glu Thr 1805 1810 1815Glu Pro Arg Phe Ser
Arg Gln Ile Ser Thr Ser Gly Glu Leu Ser 1820 1825 1830Phe Asp Ser
Leu Ala Ser Glu Phe Ser Phe Ser Lys Leu Ala Ala 1835 1840 1845Leu
Asn Thr Ser Lys Tyr Leu Glu Leu Asn Ser Leu Pro Ser Lys 1850 1855
1860Glu Thr Cys Glu Asn Arg Leu Asp Trp Lys Glu Gln Glu Ser Leu
1865 1870 1875Asn Phe Leu Ile Gly Arg Leu Leu Asp Asp Gly Cys Val
His Glu 1880 1885 1890Ala Ser Arg Val Cys Arg Tyr Phe His Phe Tyr
Asn Pro Asp Val 1895 1900 1905Ala Leu Val Leu His Cys Arg Ala Leu
Ala Ser Gly Glu Ala Ser 1910 1915 1920Met Glu Asp Leu His Pro Glu
Ile His Ala Leu Leu Gln Ser Ala 1925 1930 1935Glu Leu Leu Glu Glu
Glu Ala Pro Asp Ile Pro Leu Arg Arg Val 1940 1945 1950His Ser Thr
Ser Ser Leu Asp Ser Gln Lys Phe Val Thr Val Pro 1955 1960 1965Ser
Ser Asn Glu Val Val Thr Asn Leu Glu Val Leu Thr Ser Lys 1970 1975
1980Cys Leu His Gly Lys Asn Tyr Cys Arg Gln Val Leu Cys Leu Tyr
1985 1990 1995Asp Leu Ala Lys Glu Leu Gly Cys Ser Tyr Thr Asp Val
Ala Ala 2000 2005 2010Gln Asp Gly Glu Ala Met Leu Arg Lys Ile Leu
Ala Ser Gln Gln 2015 2020 2025Pro Asp Arg Cys Lys Arg Ala Gln Ala
Phe Ile Ser Thr Gln Gly 2030 2035 2040Leu Lys Pro Asp Thr Val Ala
Glu Leu Val Ala Glu Glu Val Thr 2045 2050 2055Arg Glu Leu Leu Thr
Ser Ser Gln Gly Thr Gly His Lys Gln Met 2060 2065 2070Phe Asn Pro
Thr Glu Glu Ser Gln Thr Phe Leu Gln Leu Thr Thr 2075 2080 2085Leu
Cys Gln Asp Arg Thr Leu Val Gly Met Lys Leu Leu Asp Lys 2090 2095
2100Ile Ser Ser Val Pro His Gly Glu Leu Ser Cys Thr Thr Glu Leu
2105 2110 2115Leu Ile Leu Ala His His Cys Phe Thr Leu Thr Cys His
Met Glu 2120 2125 2130Gly Ile Ile Arg Val Leu Gln Ala Ala His Met
Leu Thr Asp Asn 2135 2140 2145His Leu Ala Pro Ser Glu Glu Tyr Gly
Leu Val Val Arg Leu Leu 2150 2155 2160Thr Gly Ile Gly Arg Tyr Asn
Glu Met Thr Tyr Ile Phe Asp Leu 2165 2170 2175Leu His Lys Lys His
Tyr Phe Glu Val Leu Met Arg Lys Lys Leu 2180 2185 2190Asp Pro Ser
Gly Thr Leu Lys Thr Ala Leu Leu Asp Tyr Ile Lys 2195 2200 2205Arg
Cys Arg Pro Gly Asp Ser Glu Lys His Asn Met Ile Ala Leu 2210 2215
2220Cys Phe Ser Met Cys Arg Glu Ile Gly Glu Asn His Glu Ala Ala
2225 2230 2235Ala Arg Ile Gln Leu Lys Leu Ile Glu Ser Gln Pro Trp
Glu Asp 2240 2245 2250Ser Leu Lys Asp Gly His Gln Leu Lys Gln Leu
Leu Leu Lys Ala 2255 2260 2265Leu Thr Leu Met Leu Asp Ala Ala Glu
Ser Tyr Ala Lys Asp Ser 2270 2275 2280Cys Val Arg Gln Ala Gln His
Cys Gln Arg Leu Thr Lys Leu Ile 2285 2290 2295Thr Leu Gln Ile His
Phe Leu Asn Thr Gly Gln Asn Thr Met Leu 2300 2305 2310Ile Asn Leu
Gly Arg His Lys Leu Met Asp Cys Ile Leu Ala Leu 2315 2320 2325Pro
Arg Phe Tyr Gln Ala Ser Ile Val Ala Glu Ala Tyr Asp Phe 2330 2335
2340Val Pro Asp Trp Ala Glu Ile Leu Tyr Gln Gln Val Ile Leu Lys
2345 2350 2355Gly Asp Phe Asn Tyr Leu Glu Glu Phe Lys Gln Gln Arg
Leu Leu 2360 2365 2370Lys Ser Ser Ile Phe Glu Glu Ile Ser Lys Lys
Tyr Lys Gln His 2375 2380 2385Gln Pro Thr Asp Met Val Met Glu Asn
Leu Lys Lys Leu Leu Thr 2390 2395 2400Tyr Cys Glu Asp Val Tyr Leu
Tyr Tyr Lys Leu Ala Tyr Glu His 2405 2410 2415Lys Phe Tyr Glu Ile
Val Asn Val Leu Leu Lys Asp Pro Gln Thr 2420 2425 2430Gly Cys Cys
Leu Lys Asp Met Leu Ala Gly 2435 2440166245PRThomo sapiens 166Met
Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10
15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met Leu Leu Val Pro
20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser Arg Ala Gln Leu
Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser
Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg
Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe Leu Trp Glu Asp
Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala
Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu
Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser
Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser
Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe His145 150 155 160Asn
Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val Ile Leu His Ile 165 170
175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg Val Leu Asn Cys Phe Thr
180 185 190Leu Pro Leu Pro Ala Gln Ala Val Asp Met Ile Ile Asp Thr
Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe Val Leu Ser Ser Leu Gly
Trp Ile Tyr Ile 210 215 220Phe Asp Val Val Asp Gly Thr Tyr Val Ala
Arg Gly Phe Ser Thr Ser225 230 235 240Gln Arg Arg His Val
245167427PRTHomo sapiens 167Met Ala Ala Glu Glu Gly Val Ala Ser Ala
Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val
Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln
Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly
Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro
Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe
Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr
Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu
Leu Ile Tyr Glu
Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu Tyr
Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135 140Gln
Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe His145 150
155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val Ile Leu His
Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg Val Leu Asn
Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val Asp Met Ile
Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe Val Leu Ser
Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val Asp Gly Thr
Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His Lys Glu Asp
Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250 255Ser Ser
Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val 260 265
270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn Leu Tyr
275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg Ile Leu
Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp Glu Asp
Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu Ala Lys
Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln Leu Ser
Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu Val Ser
Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu Glu Ser
Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375 380Ala
Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu Gln385 390
395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile
Met 405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu Leu 420
425168555PRTHomo sapiens 168Met Ala Ala Glu Glu Gly Val Ala Ser Ala
Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val
Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln
Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly
Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro
Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe
Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr
Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu
Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120
125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp
130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser
Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys
Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile
Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala
Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu
Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val
Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230 235
240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile
245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val
Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn
Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys
Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly
Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met
Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys
Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys
Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360
365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp
370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val
Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg
Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile
Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe
Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp
Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr
Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470 475
480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Asp Phe Val Trp Phe Asp
485 490 495Ser Arg Arg Val Phe Lys Gln Thr His Asp Pro Trp Lys Cys
Gln His 500 505 510Cys Gly His Ser Leu Ser Ser Gln Trp Leu Gly Lys
Val Leu Asn Ser 515 520 525His Thr Cys Thr Arg Gly Arg Asp Arg Lys
Ser Ser Ala Gly His Ser 530 535 540Lys Phe Leu Phe Glu Glu Gln Gly
Lys Ser Phe545 550 555169576PRTHomo sapiens 169Met Ala Ala Glu Glu
Gly Val Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala
Ala Met Gly Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala
Glu Ala Met Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln
Pro Glu Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val
Leu Ser Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75
80Glu Gly Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser
85 90 95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr
Glu 100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys
Asp Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln
Lys Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser
Leu Arg Ile Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu
Phe Ile Asn Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu
Arg Asp Ala Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro
Leu Pro Ala Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200
205Cys Arg Gly Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile
210 215 220Phe Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu
Ala Leu225 230 235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln
Glu Pro Ala Lys Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser
Gln Asp Leu Asp Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser
Ala Val Ala Leu Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro
Gly His Leu Leu Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile
Gln Gly Pro Lys Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315
320Ser Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg
325 330 335Ser Trp Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys
Asn Ser 340 345 350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln
Asp Ile Leu His 355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser
Thr Ser Val Gln Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met
His Gly Gln Tyr Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys
Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser
Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr
Gly Phe Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440
445Thr Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser
450 455 460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln
Gln Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu
Ile Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu
Met Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His
Leu Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu
Glu Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe
Phe Leu Lys Ser Lys Glu Asn Leu Leu Ile His Pro Gln545 550 555
560Asn Leu Leu Tyr Leu Ile Ser Leu Ile Thr Cys His Pro Ile Tyr Ile
565 570 575170559PRTHomo sapiens 170Met Ala Ala Glu Glu Gly Val Ala
Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly
Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met
Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala
Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu
Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly
Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr
Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys
Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp
Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu
Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu
Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys
Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn
Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp
Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345
350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His
355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln
Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr
Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro
Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu
Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala
Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr
Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu
Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470
475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly
Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly
Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp
Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile
Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser
Lys Glu Asn Leu Phe Asn Pro Ser545 550 555171576PRTHomo sapiens
171Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala Gly Gly Ser1
5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met Leu Leu Val
Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser Arg Ala Gln
Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr Ala Ala Gly
Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg Gly Gly Gly
Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe Leu Trp Glu
Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro Lys Leu Leu
Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr Glu Phe Asn
Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu Tyr Ser Cys
Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135 140Gln Asp Ile
Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe His145 150 155
160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val Ile Leu His Ile
165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg Val Leu Asn Cys
Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val Asp Met Ile Ile
Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe Val Leu Ser Ser
Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val Asp Gly Thr Tyr
Val Ala His Val Asp Leu Ala Leu225 230 235 240His Lys Glu Asp Met
Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250 255Ser Ser Phe
Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val 260 265 270Ile
Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn Leu Tyr 275 280
285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg Ile Leu Glu Asp
290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp Glu Asp Asp Pro
Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser
Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln Leu Ser Ser Leu
Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu Val Ser Cys Cys
Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu Glu Ser Pro Glu
Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375 380Ala Phe Ile
Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu Gln385 390 395
400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile Met
405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys Val
Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr Trp Glu Val Glu
Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp Leu Glu Thr Gln
Gly Met Gln Cys Ser Ser 450
455 460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln
Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile
Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met
Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu
Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu
Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe
Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys
Ser Ser Val Leu Ile Ser Leu Ile Thr Cys His Pro Ile Tyr Ile 565 570
5751722443PRTHomo sapiens 172Met Ala Ala Glu Glu Gly Val Ala Ser
Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg
Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly
Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu
Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr
Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro
Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro
Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys
Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp
Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu
Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu
Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys
Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn
Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp
Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345
350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His
355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln
Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr
Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro
Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu
Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala
Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr
Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu
Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470
475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly
Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly
Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp
Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile
Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser
Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val
Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg
Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585
590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu
595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile
Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu
Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu
Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp
Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val
Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val
Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln
Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710
715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys
Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly
Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr
Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys
Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp
Phe Val His Gln Val Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe
Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Met Tyr 805 810 815Trp Ile
Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser 820 825
830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg
835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln
Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys
Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala
Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe
Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp
Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr Ser Cys
Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg
Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950
955 960Leu Leu Arg Leu Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu
Pro 965 970 975Val Gln Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His
Ser Gln Phe 980 985 990Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His
Leu Leu Tyr Val Tyr 995 1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro
Glu Asn Cys Pro Phe Leu Glu 1010 1015 1020Lys Lys Glu Leu His Glu
Ala His Pro Trp Phe Glu Phe Leu Val 1025 1030 1035Gln Cys Arg Gln
Val Ala Ser Asn Leu Thr Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln
Ala Ser Leu Ala Asn Ala Gln Ile Leu Ile Pro Thr Asn 1055 1060
1065Gln Ala Ser Val Ser Ser Met Leu Leu Glu Gly His Thr Leu Leu
1070 1075 1080Ala Leu Ala Thr Thr Met Tyr Ser Pro Gly Gly Val Ser
Gln Val 1085 1090 1095Val Gln Asn Glu Glu Asn Glu Asn Cys Leu Lys
Lys Val Asp Pro 1100 1105 1110Gln Leu Leu Lys Met Ala Leu Thr Pro
Tyr Pro Lys Leu Lys Thr 1115 1120 1125Ala Leu Phe Pro Gln Cys Thr
Pro Pro Ser Val Leu Pro Ser Asp 1130 1135 1140Ile Thr Ile Tyr His
Leu Ile Gln Ser Leu Ser Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu
Phe Gly Trp Gln Ser Ala Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp
Ala Trp Ser His Leu Pro His Phe Ser Ser Pro Asp Leu Val 1175 1180
1185Asn Lys Tyr Ala Ile Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu
1190 1195 1200His Asn Gly Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu
Val Gln 1205 1210 1215Glu Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu
Ile Gln Gln Val 1220 1225 1230Gly Asn Glu Ala Tyr Val Ile Gly Leu
Ser Ser Phe His Ile Pro 1235 1240 1245Ser Ile Gly Ala Ala Cys Val
Cys Phe Leu Glu Leu Leu Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu
Arg Val Asp Met Lys Val Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr
Lys Cys Arg Asn Glu Asp Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg
Glu Ser Val Ala Glu Lys Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300
1305Lys Thr Thr Thr Glu Glu Leu Leu Val Leu Leu Glu Glu Gly Thr
1310 1315 1320Trp Asn Ser Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser
Ser Glu 1325 1330 1335Ser Ser Ser Gln Trp Ala Leu Val Val Gln Phe
Cys Arg Leu His 1340 1345 1350Asn Met Lys Leu Ser Ile Ser Tyr Leu
Arg Glu Cys Ala Lys Ala 1355 1360 1365Asn Asp Trp Leu Gln Phe Ile
Ile His Ser Gln Leu His Asn Tyr 1370 1375 1380His Pro Ala Glu Val
Lys Ser Leu Ile Gln Tyr Phe Ser Pro Val 1385 1390 1395Ile Gln Asp
His Leu Arg Leu Ala Phe Glu Asn Leu Pro Ser Val 1400 1405 1410Pro
Thr Ser Lys Met Asp Ser Asp Gln Val Cys Asn Lys Cys Pro 1415 1420
1425Gln Glu Leu Gln Gly Ser Lys Gln Glu Met Thr Asp Leu Phe Glu
1430 1435 1440Ile Leu Leu Gln Cys Ser Glu Glu Pro Asp Ser Trp His
Trp Leu 1445 1450 1455Leu Val Glu Ala Val Lys Gln Gln Ala Pro Ile
Leu Ser Val Leu 1460 1465 1470Ala Ser Cys Leu Gln Gly Ala Ser Ala
Ile Ser Cys Leu Cys Val 1475 1480 1485Trp Ile Ile Thr Ser Val Glu
Asp Asn Val Ala Thr Glu Ala Met 1490 1495 1500Gly His Ile Gln Asp
Ser Thr Glu Asp His Thr Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser
Val Ile Trp Arg Thr Leu Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys
Thr Leu Ile Arg Gly Phe Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540
1545Leu Leu Leu Val Met Glu Met Tyr Glu Leu Cys Met Phe Phe Arg
1550 1555 1560Asn Tyr Lys Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln
Lys Ser 1565 1570 1575Leu Glu Thr Leu Asn Thr Ala Ala Thr Lys Val
His Pro Val Ile 1580 1585 1590Pro Ala Met Trp Leu Glu Asp Gln Val
Cys Phe Leu Leu Lys Leu 1595 1600 1605Met Leu Gln Gln Cys Lys Thr
Gln Tyr Glu Leu Gly Lys Leu Leu 1610 1615 1620Gln Leu Phe Val Glu
Arg Glu His Leu Phe Ser Asp Gly Pro Asp 1625 1630 1635Val Lys Lys
Leu Cys Ile Leu Cys Gln Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile
Ala Ile Asn His Thr Ile Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660
1665Leu Gln His Glu Cys Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp
1670 1675 1680Gly Gln Phe Ala Leu Ala Arg Arg Val Ala Glu Leu Ala
Glu Leu 1685 1690 1695Pro Val Asp Asn Leu Val Ile Lys Glu Ile Thr
Gln Glu Met Gln 1700 1705 1710Thr Leu Lys His Ile Glu Gln Trp Ser
Leu Lys Gln Ala Arg Ile 1715 1720 1725Asp Phe Trp Lys Lys Cys His
Glu Asn Phe Lys Lys Asn Ser Ile 1730 1735 1740Ser Ser Lys Ala Ala
Ser Ser Phe Phe Ser Thr Gln Ala His Val 1745 1750 1755Ala Cys Glu
His Pro Thr Gly Trp Ser Ser Met Glu Glu Arg His 1760 1765 1770Leu
Leu Leu Thr Leu Ala Gly His Trp Leu Ala Gln Glu Asp Val 1775 1780
1785Val Pro Leu Asp Lys Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu
1790 1795 1800Cys Arg Ile Thr Gln His Thr Leu Gly Arg Asn Gln Glu
Glu Thr 1805 1810 1815Glu Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser
Gly Glu Leu Ser 1820 1825 1830Phe Asp Ser Leu Ala Ser Glu Phe Ser
Phe Ser Lys Leu Ala Ala 1835 1840 1845Leu Asn Thr Ser Lys Tyr Leu
Glu Leu Asn Ser Leu Pro Ser Lys 1850 1855 1860Glu Thr Cys Glu Asn
Arg Leu Asp Trp Lys Glu Gln Glu Ser Leu 1865 1870 1875Asn Phe Leu
Ile Gly Arg Leu Leu Asp Asp Gly Cys Val His Glu 1880 1885 1890Ala
Ser Arg Val Cys Arg Tyr Phe His Phe Tyr Asn Pro Asp Val 1895 1900
1905Ala Leu Val Leu His Cys Arg Ala Leu Ala Ser Gly Glu Ala Ser
1910 1915 1920Met Glu Asp Leu His Pro Glu Ile His Ala Leu Leu Gln
Ser Ala 1925 1930 1935Glu Leu Leu Glu Glu Glu Ala Pro Asp Ile Pro
Leu Arg Arg Val 1940 1945 1950His Ser Thr Ser Ser Leu Asp Ser Gln
Lys Phe Val Thr Val Pro 1955 1960 1965Ser Ser Asn Glu Val Val Thr
Asn Leu Glu Val Leu Thr Ser Lys 1970 1975 1980Cys Leu His Gly Lys
Asn Tyr Cys Arg Gln Val Leu Cys Leu Tyr 1985 1990 1995Asp Leu Ala
Lys Glu Leu Gly Cys Ser Tyr Thr Asp Val Ala Ala 2000 2005 2010Gln
Asp Gly Glu Ala Met Leu Arg Lys Ile Leu Ala Ser Gln Gln 2015 2020
2025Pro Asp Arg Cys Lys Arg Ala Gln Ala Phe Ile Ser Thr Gln Gly
2030 2035 2040Leu Lys Pro Asp Thr Val Ala Glu Leu Val Ala Glu Glu
Val Thr 2045 2050 2055Arg Glu Leu Leu Thr Ser Ser Gln Gly Thr Gly
His Lys Gln Met 2060 2065 2070Phe Asn Pro Thr Glu Glu Ser Gln Thr
Phe Leu Gln Leu Thr Thr 2075 2080 2085Leu Cys Gln Asp Arg Thr Leu
Val Gly Met Lys Leu Leu Asp Lys 2090 2095 2100Ile Ser Ser Val Pro
His Gly Glu Leu Ser Cys Thr Thr Glu Leu 2105 2110 2115Leu Ile Leu
Ala His His Cys Phe Thr Leu Thr Cys His Met Glu 2120 2125 2130Gly
Ile Ile Arg Val Leu Gln Ala Ala His Met Leu Thr Asp Asn 2135 2140
2145His Leu Ala Pro Ser Glu Glu Tyr Gly Leu Val Val Arg Leu Leu
2150 2155 2160Thr Gly Ile Gly Arg Tyr Asn Glu Met Thr Tyr Ile Phe
Asp Leu 2165 2170 2175Leu His Lys Lys His Tyr Phe Glu Val Leu Met
Arg Lys Lys Leu 2180 2185 2190Asp Pro Ser Gly Thr Leu Lys Thr Ala
Leu Leu Asp Tyr Ile Lys 2195 2200 2205Arg Cys Arg Pro Gly Asp Ser
Glu Lys His Asn Met Ile Ala Leu 2210 2215 2220Cys Phe Ser Met Cys
Arg Glu Ile Gly Glu Asn His Glu Ala Ala 2225 2230 2235Ala Arg Ile
Gln Leu Lys Leu Ile Glu Ser Gln Pro Trp Glu Asp 2240 2245 2250Ser
Leu Lys Asp Gly His Gln Leu Lys Gln Leu Leu Leu Lys Ala 2255 2260
2265Leu Thr Leu Met Leu Asp Ala Ala Glu Ser Tyr Ala Lys Asp Ser
2270 2275 2280Cys Val Arg Gln Ala Gln His Cys Gln Arg Leu Thr Lys
Leu Ile 2285 2290 2295Thr Leu Gln Ile His Phe Leu Asn Thr Gly Gln
Asn Thr Met Leu 2300 2305 2310Ile Asn Leu Gly Arg His Lys Leu Met
Asp Cys Ile Leu Ala Leu 2315 2320 2325Pro Arg Phe Tyr Gln Ala Ser
Ile Val
Ala Glu Ala Tyr Asp Phe 2330 2335 2340Val Pro Asp Trp Ala Glu Ile
Leu Tyr Gln Gln Val Ile Leu Lys 2345 2350 2355Gly Asp Phe Asn Tyr
Leu Glu Glu Phe Lys Gln Gln Arg Leu Leu 2360 2365 2370Lys Ser Ser
Ile Phe Glu Glu Ile Ser Lys Lys Tyr Lys Gln His 2375 2380 2385Gln
Pro Thr Asp Met Val Met Glu Asn Leu Lys Lys Leu Leu Thr 2390 2395
2400Tyr Cys Glu Asp Val Tyr Leu Tyr Tyr Lys Leu Ala Tyr Glu His
2405 2410 2415Lys Phe Tyr Glu Ile Val Asn Val Leu Leu Lys Asp Pro
Gln Thr 2420 2425 2430Gly Cys Cys Leu Lys Asp Met Leu Ala Gly 2435
2440173898PRTHomo sapiens 173Met Ala Ala Glu Glu Gly Val Ala Ser
Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg
Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly
Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu
Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr
Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro
Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro
Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys
Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp
Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu
Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu
Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys
Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn
Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp
Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345
350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His
355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln
Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr
Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro
Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu
Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala
Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr
Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu
Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470
475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly
Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly
Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp
Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile
Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser
Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val
Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg
Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585
590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu
595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile
Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu
Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu
Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp
Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val
Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val
Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln
Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710
715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys
Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly
Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr
Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys
Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp
Phe Val His Gln Val Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe
Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile
Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser 820 825
830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg
835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln
Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys
Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala
Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu174919PRTHomo sapiens
174Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala Gly Gly Ser1
5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met Leu Leu Val
Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser Arg Ala Gln
Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr Ala Ala Gly
Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg Gly Gly Gly
Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe Leu Trp Glu
Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro Lys Leu Leu
Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr Glu Phe Asn
Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu Tyr Ser Cys
Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135 140Gln Asp Ile
Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe His145 150 155
160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val Ile Leu His Ile
165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg Val Leu Asn Cys
Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val Asp Met Ile Ile
Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe Val Leu Ser Ser
Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val Asp Gly Thr Tyr
Val Ala His Val Asp Leu Ala Leu225 230 235 240His Lys Glu Asp Met
Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250 255Ser Ser Phe
Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val 260 265 270Ile
Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn Leu Tyr 275 280
285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg Ile Leu Glu Asp
290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp Glu Asp Asp Pro
Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser
Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln Leu Ser Ser Leu
Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu Val Ser Cys Cys
Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu Glu Ser Pro Glu
Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375 380Ala Phe Ile
Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu Gln385 390 395
400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile Met
405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys Val
Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr Trp Glu Val Glu
Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp Leu Glu Thr Gln
Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys Cys Ile Pro Val
Asp Ser Ser Gly Asp Gln Gln Leu465 470 475 480Cys Phe Val Leu Thr
Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490 495Thr Gln Glu
Glu Phe Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser 500 505 510Thr
Val Asp Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys Ser Ile 515 520
525Pro Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr
530 535 540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro
Ser Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln Phe Asp His Leu
Ser Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu Glu Leu Ile Pro
Ala Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg Glu Ser Tyr Ser
Glu Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln Leu Leu Asn Leu
Thr Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615 620Leu Phe Ile
His Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly Val625 630 635
640Asn Ile Leu Thr Ser Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile Lys
645 650 655Phe Pro Trp Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp Val
His Glu 660 665 670Asn Val Pro Lys Val Lys Glu Ser Asn Ile Trp Lys
Lys Leu Ser Phe 675 680 685Glu Glu Val Ile Ala Ser Ala Ile Leu Asn
Asn Lys Ile Pro Glu Ala 690 695 700Gln Thr Phe Phe Arg Ile Asp Ser
His Ser Ala Gln Lys Leu Glu Glu705 710 715 720Leu Ile Gly Ile Gly
Leu Asn Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730 735Asn Ile Lys
Glu Ala Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val 740 745 750Lys
Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys Asn Ile 755 760
765Arg Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu
770 775 780Lys Glu Lys Arg Thr Ile Asp Phe Val His Gln Val Glu Lys
Leu Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn Met Gln Ile Gln
Ser Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln Asp Phe Phe Lys
His Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys Tyr Asp Cys Lys
Asp Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile Val Leu Asn Trp
Ala Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855 860Ile Leu Leu
Pro Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser Pro865 870 875
880Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp Trp Leu Asn Ile
885 890 895Ile Leu Trp Ile Gly Glu Phe Gln Thr Ser Ile Val Met Leu
His Phe 900 905 910Ser Arg Thr Asn Gly Pro Phe 9151751028PRTHomo
sapiens 175Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala Gly
Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met Leu
Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser Arg
Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr Ala
Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg Gly
Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe Leu
Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro Lys
Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr Glu
Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu Tyr
Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135 140Gln
Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe His145 150
155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val Ile Leu His
Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg Val Leu Asn
Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val Asp Met Ile
Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe Val Leu Ser
Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val Asp Gly Thr
Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His Lys Glu Asp
Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250 255Ser Ser
Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val 260 265
270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn Leu Tyr
275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg Ile Leu
Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp Glu Asp
Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu Ala Lys
Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln Leu Ser
Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu Val Ser
Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu Glu Ser
Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375 380Ala
Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu Gln385 390
395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile
Met 405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys
Val Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr Trp Glu Val
Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp Leu Glu Thr
Gln Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys Cys Ile Pro
Val Asp Ser Ser Gly Asp Gln Gln Leu465 470 475 480Cys Phe Val Leu
Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490 495Thr Gln
Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser 500 505
510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys Ser Ile
515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg Gln Leu
Asp Thr 530
535 540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser
Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln Phe Asp His Leu Ser
Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu Glu Leu Ile Pro Ala
Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg Glu Ser Tyr Ser Glu
Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln Leu Leu Asn Leu Thr
Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615 620Leu Phe Ile His
Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly Val625 630 635 640Asn
Ile Leu Thr Ser Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile Lys 645 650
655Phe Pro Trp Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp Val His Glu
660 665 670Asn Val Pro Lys Val Lys Glu Ser Asn Ile Trp Lys Lys Leu
Ser Phe 675 680 685Glu Glu Val Ile Ala Ser Ala Ile Leu Asn Asn Lys
Ile Pro Glu Ala 690 695 700Gln Thr Phe Phe Arg Ile Asp Ser His Ser
Ala Gln Lys Leu Glu Glu705 710 715 720Leu Ile Gly Ile Gly Leu Asn
Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730 735Asn Ile Lys Glu Ala
Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val 740 745 750Lys Gly Gln
Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys Asn Ile 755 760 765Arg
Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu 770 775
780Lys Glu Lys Arg Thr Ile Asp Phe Val His Gln Val Glu Lys Leu
Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn Met Gln Ile Gln Ser
Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln Asp Phe Phe Lys His
Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys Tyr Asp Cys Lys Asp
Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile Val Leu Asn Trp Ala
Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855 860Ile Leu Leu Pro
Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser Pro865 870 875 880Glu
Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp Trp Leu Asn Ile 885 890
895Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln His Ser Tyr Ala Ser Leu
900 905 910Gln Gln Asn Lys Trp Pro Leu Leu Thr Val Asp Val Ile Asn
Gln Asn 915 920 925Thr Ser Cys Asn Asn Tyr Met Arg Asn Glu Ile Leu
Asp Lys Leu Ala 930 935 940Arg Asn Gly Val Phe Leu Ala Ser Glu Leu
Glu Asp Phe Glu Cys Phe945 950 955 960Leu Leu Arg Leu Ser Arg Ile
Gly Gly Val Ile Gln Asp Thr Leu Pro 965 970 975Val Gln Asn Tyr Lys
Thr Lys Glu Gly Trp Asp Phe His Ser Gln Phe 980 985 990Ile Leu Tyr
Cys Leu Glu His Ser Leu Gln His Leu Leu Tyr Val Tyr 995 1000
1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys Pro Phe Leu Glu
1010 1015 1020Lys Lys Arg Val Thr 10251761263PRTHomo sapiens 176Met
Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10
15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met Leu Leu Val Pro
20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser Arg Ala Gln Leu
Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser
Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg
Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe Leu Trp Glu Asp
Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala
Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu
Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser
Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser
Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe His145 150 155 160Asn
Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val Ile Leu His Ile 165 170
175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg Val Leu Asn Cys Phe Thr
180 185 190Leu Pro Leu Pro Ala Gln Ala Val Asp Met Ile Ile Asp Thr
Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe Val Leu Ser Ser Leu Gly
Trp Ile Tyr Ile 210 215 220Phe Asp Val Val Asp Gly Thr Tyr Val Ala
His Val Asp Leu Ala Leu225 230 235 240His Lys Glu Asp Met Cys Asn
Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250 255Ser Ser Phe Thr Ser
Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val 260 265 270Ile Val Ser
Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn Leu Tyr 275 280 285Phe
Arg Gln His Pro Gly His Leu Leu Cys Glu Arg Ile Leu Glu Asp 290 295
300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp Glu Asp Asp Pro Val
Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser Phe
Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln Leu Ser Ser Leu Asn
Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu Val Ser Cys Cys Ala
Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu Glu Ser Pro Glu Ser
Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375 380Ala Phe Ile Pro
Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu Gln385 390 395 400Lys
Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410
415His Ile Ser Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val
420 425 430Thr Gly Phe Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met
Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met
Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser
Ser Gly Asp Gln Gln Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn
Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe
Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp
Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro
Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535
540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser
Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln Phe Asp His Leu Ser
Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu Glu Leu Ile Pro Ala
Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg Glu Ser Tyr Ser Glu
Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln Leu Leu Asn Leu Thr
Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615 620Leu Phe Ile His
Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly Val625 630 635 640Asn
Ile Leu Thr Ser Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile Lys 645 650
655Phe Pro Trp Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp Val His Glu
660 665 670Asn Val Pro Lys Val Lys Glu Ser Asn Ile Trp Lys Lys Leu
Ser Phe 675 680 685Glu Glu Val Ile Ala Ser Ala Ile Leu Asn Asn Lys
Ile Pro Glu Ala 690 695 700Gln Thr Phe Phe Arg Ile Asp Ser His Ser
Ala Gln Lys Leu Glu Glu705 710 715 720Leu Ile Gly Ile Gly Leu Asn
Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730 735Asn Ile Lys Glu Ala
Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val 740 745 750Lys Gly Gln
Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys Asn Ile 755 760 765Arg
Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu 770 775
780Lys Glu Lys Arg Thr Ile Asp Phe Val His Gln Val Glu Lys Leu
Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn Met Gln Ile Gln Ser
Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln Asp Phe Phe Lys His
Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys Tyr Asp Cys Lys Asp
Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile Val Leu Asn Trp Ala
Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855 860Ile Leu Leu Pro
Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser Pro865 870 875 880Glu
Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp Trp Leu Asn Ile 885 890
895Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln His Ser Tyr Ala Ser Leu
900 905 910Gln Gln Asn Lys Trp Pro Leu Leu Thr Val Asp Val Ile Asn
Gln Asn 915 920 925Thr Ser Cys Asn Asn Tyr Met Arg Asn Glu Ile Leu
Asp Lys Leu Ala 930 935 940Arg Asn Gly Val Phe Leu Ala Ser Glu Leu
Glu Asp Phe Glu Cys Phe945 950 955 960Leu Leu Arg Leu Ser Arg Ile
Gly Gly Val Ile Gln Asp Thr Leu Pro 965 970 975Val Gln Asn Tyr Lys
Thr Lys Glu Gly Trp Asp Phe His Ser Gln Phe 980 985 990Ile Leu Tyr
Cys Leu Glu His Ser Leu Gln His Leu Leu Tyr Val Tyr 995 1000
1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys Pro Phe Leu Glu
1010 1015 1020Lys Lys Glu Leu His Glu Ala His Pro Trp Phe Glu Phe
Leu Val 1025 1030 1035Gln Cys Arg Gln Val Ala Ser Asn Leu Thr Asp
Pro Lys Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu Ala Asn Ala Gln
Ile Leu Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser Val Ser Ser Met
Leu Leu Glu Gly His Thr Leu Leu 1070 1075 1080Ala Leu Ala Thr Thr
Met Tyr Ser Pro Gly Gly Val Ser Gln Val 1085 1090 1095Val Gln Asn
Glu Glu Asn Glu Asn Cys Leu Lys Lys Val Asp Pro 1100 1105 1110Gln
Leu Leu Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr 1115 1120
1125Ala Leu Phe Pro Gln Cys Thr Pro Pro Ser Val Leu Pro Ser Asp
1130 1135 1140Ile Thr Ile Tyr His Leu Ile Gln Ser Leu Ser Pro Phe
Asp Pro 1145 1150 1155Ser Arg Leu Phe Gly Trp Gln Ser Ala Asn Thr
Leu Ala Ile Gly 1160 1165 1170Asp Ala Trp Ser His Leu Pro His Phe
Ser Ser Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr Ala Ile Val Glu
Arg Leu Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His Asn Gly Arg Pro
Ser Phe Ala Phe Gly Thr Phe Leu Val Gln 1205 1210 1215Glu Leu Ile
Lys Ser Lys Thr Pro Lys Gln Leu Ile Gln Gln Val 1220 1225 1230Gly
Asn Glu Ala Tyr Val Ile Gly Leu Ser Ser Phe His Ile Thr 1235 1240
1245Phe Asn Arg Ser Cys Met Cys Leu Phe Leu Arg Ile Ala Trp Pro
1250 1255 12601771441PRTHomo sapiens 177Met Ala Ala Glu Glu Gly Val
Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met
Gly Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala
Met Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu
Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser
Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu
Gly Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90
95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu
100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp
Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys
Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu
Arg Ile Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe
Ile Asn Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg
Asp Ala Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu
Pro Ala Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys
Arg Gly Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215
220Phe Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala
Leu225 230 235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu
Pro Ala Lys Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln
Asp Leu Asp Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala
Val Ala Leu Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly
His Leu Leu Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln
Gly Pro Lys Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser
Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330
335Ser Trp Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser
340 345 350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile
Leu His 355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser
Val Gln Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly
Gln Tyr Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser
Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln
Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe
Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr
Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455
460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln
Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile
Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met
Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu
Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu
Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe
Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys
Ser Ser Val Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr 565 570
575Leu Arg Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser
580 585 590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe
Ser Glu 595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn
Gln Ile Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu Asp Glu
His Leu Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile
Asn Glu Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu
Thr Asp Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro
Lys Val Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu
Glu Val Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695
700Gln Thr Phe Phe Arg Ile Asp Ser
His Ser Ala Gln Lys Leu Glu Glu705 710 715 720Leu Ile Gly Ile Gly
Leu Asn Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730 735Asn Ile Lys
Glu Ala Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val 740 745 750Lys
Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys Asn Ile 755 760
765Arg Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu
770 775 780Lys Glu Lys Arg Thr Ile Asp Phe Val His Gln Val Glu Lys
Leu Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn Met Gln Ile Gln
Ser Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln Asp Phe Phe Lys
His Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys Tyr Asp Cys Lys
Asp Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile Val Leu Asn Trp
Ala Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855 860Ile Leu Leu
Pro Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser Pro865 870 875
880Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp Trp Leu Asn Ile
885 890 895Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln His Ser Tyr Ala
Ser Leu 900 905 910Gln Gln Asn Lys Trp Pro Leu Leu Thr Val Asp Val
Ile Asn Gln Asn 915 920 925Thr Ser Cys Asn Asn Tyr Met Arg Asn Glu
Ile Leu Asp Lys Leu Ala 930 935 940Arg Asn Gly Val Phe Leu Ala Ser
Glu Leu Glu Asp Phe Glu Cys Phe945 950 955 960Leu Leu Arg Leu Ser
Arg Ile Gly Gly Val Ile Gln Asp Thr Leu Pro 965 970 975Val Gln Asn
Tyr Lys Thr Lys Glu Gly Trp Asp Phe His Ser Gln Phe 980 985 990Ile
Leu Tyr Cys Leu Glu His Ser Leu Gln His Leu Leu Tyr Val Tyr 995
1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys Pro Phe Leu
Glu 1010 1015 1020Lys Lys Glu Leu His Glu Ala His Pro Trp Phe Glu
Phe Leu Val 1025 1030 1035Gln Cys Arg Gln Val Ala Ser Asn Leu Thr
Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu Ala Asn Ala
Gln Ile Leu Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser Val Ser Ser
Met Leu Leu Glu Gly His Thr Leu Leu 1070 1075 1080Ala Leu Ala Thr
Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val 1085 1090 1095Val Gln
Asn Glu Glu Asn Glu Asn Cys Leu Lys Lys Val Asp Pro 1100 1105
1110Gln Leu Leu Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr
1115 1120 1125Ala Leu Phe Pro Gln Cys Thr Pro Pro Ser Val Leu Pro
Ser Asp 1130 1135 1140Ile Thr Ile Tyr His Leu Ile Gln Ser Leu Ser
Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu Phe Gly Trp Gln Ser Ala
Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp Ala Trp Ser His Leu Pro
His Phe Ser Ser Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr Ala Ile
Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His Asn Gly
Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu Val Gln 1205 1210 1215Glu
Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu Ile Gln Gln Val 1220 1225
1230Gly Asn Glu Ala Tyr Val Ile Gly Leu Ser Ser Phe His Ile Pro
1235 1240 1245Ser Ile Gly Ala Ala Cys Val Cys Phe Leu Glu Leu Leu
Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu Arg Val Asp Met Lys Val
Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr Lys Cys Arg Asn Glu Asp
Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg Glu Ser Val Ala Glu Lys
Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300 1305Lys Thr Thr Thr Glu
Glu Leu Leu Val Leu Leu Glu Glu Gly Thr 1310 1315 1320Trp Asn Ser
Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser Ser Glu 1325 1330 1335Ser
Ser Ser Gln Trp Ala Leu Val Val Gln Phe Cys Arg Leu His 1340 1345
1350Asn Met Lys Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala Lys Ala
1355 1360 1365Asn Asp Trp Leu Gln Phe Ile Ile His Ser Gln Leu His
Asn Tyr 1370 1375 1380His Pro Ala Glu Val Lys Ser Leu Ile Gln Tyr
Phe Ser Pro Val 1385 1390 1395Ile Gln Asp His Leu Arg Leu Ala Phe
Glu Asn Leu Pro Ser Val 1400 1405 1410Pro Thr Ser Lys Met Asp Ser
Asp Gln Val Cys Asn Lys Cys Pro 1415 1420 1425Gln Glu Leu Gln Gly
Ser Lys Arg Asp Asp Arg Phe Ile 1430 1435 14401781823PRTHomo
sapiens 178Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala Gly
Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met Leu
Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser Arg
Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr Ala
Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg Gly
Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe Leu
Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro Lys
Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr Glu
Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu Tyr
Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135 140Gln
Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe His145 150
155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val Ile Leu His
Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg Val Leu Asn
Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val Asp Met Ile
Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe Val Leu Ser
Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val Asp Gly Thr
Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His Lys Glu Asp
Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250 255Ser Ser
Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val 260 265
270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn Leu Tyr
275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg Ile Leu
Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp Glu Asp
Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu Ala Lys
Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln Leu Ser
Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu Val Ser
Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu Glu Ser
Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375 380Ala
Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu Gln385 390
395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile
Met 405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys
Val Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr Trp Glu Val
Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp Leu Glu Thr
Gln Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys Cys Ile Pro
Val Asp Ser Ser Gly Asp Gln Gln Leu465 470 475 480Cys Phe Val Leu
Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490 495Thr Gln
Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser 500 505
510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys Ser Ile
515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg Gln Leu
Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn Leu Phe
Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln Phe Asp
His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu Glu Leu
Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg Glu Ser
Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln Leu Leu
Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615 620Leu
Phe Ile His Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly Val625 630
635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile
Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp
Val His Glu 660 665 670Asn Val Pro Lys Val Lys Glu Ser Asn Ile Trp
Lys Lys Leu Ser Phe 675 680 685Glu Glu Val Ile Ala Ser Ala Ile Leu
Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln Thr Phe Phe Arg Ile Asp
Ser His Ser Ala Gln Lys Leu Glu Glu705 710 715 720Leu Ile Gly Ile
Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730 735Asn Ile
Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val 740 745
750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys Asn Ile
755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn Tyr Phe
Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp Phe Val His Gln Val
Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn Met Gln
Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln Asp Phe
Phe Lys His Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys Tyr Asp
Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile Val Leu
Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855 860Ile
Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser Pro865 870
875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp Trp Leu Asn
Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln His Ser Tyr
Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp Pro Leu Leu Thr Val Asp
Val Ile Asn Gln Asn 915 920 925Thr Ser Cys Asn Asn Tyr Met Arg Asn
Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg Asn Gly Val Phe Leu Ala
Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950 955 960Leu Leu Arg Leu
Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu Pro 965 970 975Val Gln
Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His Ser Gln Phe 980 985
990Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His Leu Leu Tyr Val Tyr
995 1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys Pro Phe
Leu Glu 1010 1015 1020Lys Lys Glu Leu His Glu Ala His Pro Trp Phe
Glu Phe Leu Val 1025 1030 1035Gln Cys Arg Gln Val Ala Ser Asn Leu
Thr Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu Ala Asn
Ala Gln Ile Leu Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser Val Ser
Ser Met Leu Leu Glu Gly His Thr Leu Leu 1070 1075 1080Ala Leu Ala
Thr Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val 1085 1090 1095Val
Gln Asn Glu Glu Asn Glu Asn Cys Leu Lys Lys Val Asp Pro 1100 1105
1110Gln Leu Leu Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr
1115 1120 1125Ala Leu Phe Pro Gln Cys Thr Pro Pro Ser Val Leu Pro
Ser Asp 1130 1135 1140Ile Thr Ile Tyr His Leu Ile Gln Ser Leu Ser
Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu Phe Gly Trp Gln Ser Ala
Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp Ala Trp Ser His Leu Pro
His Phe Ser Ser Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr Ala Ile
Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His Asn Gly
Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu Val Gln 1205 1210 1215Glu
Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu Ile Gln Gln Val 1220 1225
1230Gly Asn Glu Ala Tyr Val Ile Gly Leu Ser Ser Phe His Ile Pro
1235 1240 1245Ser Ile Gly Ala Ala Cys Val Cys Phe Leu Glu Leu Leu
Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu Arg Val Asp Met Lys Val
Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr Lys Cys Arg Asn Glu Asp
Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg Glu Ser Val Ala Glu Lys
Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300 1305Lys Thr Thr Thr Glu
Glu Leu Leu Val Leu Leu Glu Glu Gly Thr 1310 1315 1320Trp Asn Ser
Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser Ser Glu 1325 1330 1335Ser
Ser Ser Gln Trp Ala Leu Val Val Gln Phe Cys Arg Leu His 1340 1345
1350Asn Met Lys Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala Lys Ala
1355 1360 1365Asn Asp Trp Leu Gln Phe Ile Ile His Ser Gln Leu His
Asn Tyr 1370 1375 1380His Pro Ala Glu Val Lys Ser Leu Ile Gln Tyr
Phe Ser Pro Val 1385 1390 1395Ile Gln Asp His Leu Arg Leu Ala Phe
Glu Asn Leu Pro Ser Val 1400 1405 1410Pro Thr Ser Lys Met Asp Ser
Asp Gln Val Cys Asn Lys Cys Pro 1415 1420 1425Gln Glu Leu Gln Gly
Ser Lys Gln Glu Met Thr Asp Leu Phe Glu 1430 1435 1440Ile Leu Leu
Gln Cys Ser Glu Glu Pro Asp Ser Trp His Trp Leu 1445 1450 1455Leu
Val Glu Ala Val Lys Gln Gln Ala Pro Ile Leu Ser Val Leu 1460 1465
1470Ala Ser Cys Leu Gln Gly Ala Ser Ala Ile Ser Cys Leu Cys Val
1475 1480 1485Trp Ile Ile Thr Ser Val Glu Asp Asn Val Ala Thr Glu
Ala Met 1490 1495 1500Gly His Ile Gln Asp Ser Thr Glu Asp His Thr
Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser Val Ile Trp Arg Thr Leu
Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys Thr Leu Ile Arg Gly Phe
Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540 1545Leu Leu Leu Val Met
Glu Met Tyr Glu Leu Cys Met Phe Phe Arg 1550 1555 1560Asn Tyr Lys
Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln Lys Ser 1565 1570 1575Leu
Glu Thr Leu Asn Thr Ala Ala Thr Lys Val His Pro Val Ile 1580 1585
1590Pro Ala Met Trp Leu Glu Asp Gln Val Cys Phe Leu Leu Lys Leu
1595 1600 1605Met Leu Gln Gln Cys Lys Thr Gln Tyr Glu Leu Gly Lys
Leu Leu 1610 1615 1620Gln Leu Phe Val Glu Arg Glu His Leu Phe Ser
Asp Gly Pro Asp 1625 1630 1635Val Lys Lys Leu Cys Ile Leu Cys Gln
Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile Ala Ile Asn His Thr Ile
Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660 1665Leu Gln His Glu Cys
Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp 1670 1675 1680Gly Gln Phe
Ala Leu Ala Arg Arg Val Ala Glu Leu Ala Glu Leu 1685 1690 1695Pro
Val Asp Asn Leu Val Ile Lys Glu Ile Thr Gln Glu Met Gln 1700 1705
1710Thr Leu Lys His Ile
Glu Gln Trp Ser Leu Lys Gln Ala Arg Ile 1715 1720 1725Asp Phe Trp
Lys Lys Cys His Glu Asn Phe Lys Lys Asn Ser Ile 1730 1735 1740Ser
Ser Lys Ala Ala Ser Ser Phe Phe Ser Thr Gln Ala His Val 1745 1750
1755Ala Cys Glu His Pro Thr Gly Trp Ser Ser Met Glu Glu Arg His
1760 1765 1770Leu Leu Leu Thr Leu Ala Gly His Trp Leu Ala Gln Glu
Asp Val 1775 1780 1785Val Pro Leu Asp Lys Leu Glu Glu Leu Glu Lys
Gln Ile Trp Leu 1790 1795 1800Cys Arg Ile Thr Gln His Thr Leu Gly
Arg Asn Gln Glu Glu Thr 1805 1810 1815Glu Pro Arg Phe Ser
18201791856PRTHomo sapiens 179Met Ala Ala Glu Glu Gly Val Ala Ser
Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg
Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly
Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu
Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr
Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro
Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro
Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys
Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp
Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu
Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu
Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys
Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn
Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp
Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345
350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His
355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln
Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr
Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro
Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu
Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala
Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr
Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu
Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470
475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly
Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly
Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp
Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile
Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser
Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val
Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg
Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585
590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu
595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile
Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu
Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu
Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp
Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val
Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val
Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln
Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710
715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys
Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly
Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr
Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys
Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp
Phe Val His Gln Val Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe
Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile
Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser 820 825
830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg
835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln
Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys
Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala
Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe
Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp
Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr Ser Cys
Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg
Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950
955 960Leu Leu Arg Leu Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu
Pro 965 970 975Val Gln Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His
Ser Gln Phe 980 985 990Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His
Leu Leu Tyr Val Tyr 995 1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro
Glu Asn Cys Pro Phe Leu Glu 1010 1015 1020Lys Lys Glu Leu His Glu
Ala His Pro Trp Phe Glu Phe Leu Val1025 1030 1035Gln Cys Arg Gln
Val Ala Ser Asn Leu Thr Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln
Ala Ser Leu Ala Asn Ala Gln Ile Leu Ile Pro Thr Asn 1055 1060
1065Gln Ala Ser Val Ser Ser Met Leu Leu Glu Gly His Thr Leu Leu
1070 1075 1080Ala Leu Ala Thr Thr Met Tyr Ser Pro Gly Gly Val Ser
Gln Val 1085 1090 1095Val Gln Asn Glu Glu Asn Glu Asn Cys Leu Lys
Lys Val Asp Pro 1100 1105 1110Gln Leu Leu Lys Met Ala Leu Thr Pro
Tyr Pro Lys Leu Lys Thr 1115 1120 1125Ala Leu Phe Pro Gln Cys Thr
Pro Pro Ser Val Leu Pro Ser Asp 1130 1135 1140Ile Thr Ile Tyr His
Leu Ile Gln Ser Leu Ser Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu
Phe Gly Trp Gln Ser Ala Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp
Ala Trp Ser His Leu Pro His Phe Ser Ser Pro Asp Leu Val 1175 1180
1185Asn Lys Tyr Ala Ile Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu
1190 1195 1200His Asn Gly Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu
Val Gln 1205 1210 1215Glu Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu
Ile Gln Gln Val 1220 1225 1230Gly Asn Glu Ala Tyr Val Ile Gly Leu
Ser Ser Phe His Ile Pro 1235 1240 1245Ser Ile Gly Ala Ala Cys Val
Cys Phe Leu Glu Leu Leu Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu
Arg Val Asp Met Lys Val Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr
Lys Cys Arg Asn Glu Asp Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg
Glu Ser Val Ala Glu Lys Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300
1305Lys Thr Thr Thr Glu Glu Leu Leu Val Leu Leu Glu Glu Gly Thr
1310 1315 1320Trp Asn Ser Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser
Ser Glu 1325 1330 1335Ser Ser Ser Gln Trp Ala Leu Val Val Gln Phe
Cys Arg Leu His 1340 1345 1350Asn Met Lys Leu Ser Ile Ser Tyr Leu
Arg Glu Cys Ala Lys Ala 1355 1360 1365Asn Asp Trp Leu Gln Phe Ile
Ile His Ser Gln Leu His Asn Tyr 1370 1375 1380His Pro Ala Glu Val
Lys Ser Leu Ile Gln Tyr Phe Ser Pro Val 1385 1390 1395Ile Gln Asp
His Leu Arg Leu Ala Phe Glu Asn Leu Pro Ser Val 1400 1405 1410Pro
Thr Ser Lys Met Asp Ser Asp Gln Val Cys Asn Lys Cys Pro 1415 1420
1425Gln Glu Leu Gln Gly Ser Lys Gln Glu Met Thr Asp Leu Phe Glu
1430 1435 1440Ile Leu Leu Gln Cys Ser Glu Glu Pro Asp Ser Trp His
Trp Leu 1445 1450 1455Leu Val Glu Ala Val Lys Gln Gln Ala Pro Ile
Leu Ser Val Leu 1460 1465 1470Ala Ser Cys Leu Gln Gly Ala Ser Ala
Ile Ser Cys Leu Cys Val 1475 1480 1485Trp Ile Ile Thr Ser Val Glu
Asp Asn Val Ala Thr Glu Ala Met 1490 1495 1500Gly His Ile Gln Asp
Ser Thr Glu Asp His Thr Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser
Val Ile Trp Arg Thr Leu Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys
Thr Leu Ile Arg Gly Phe Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540
1545Leu Leu Leu Val Met Glu Met Tyr Glu Leu Cys Met Phe Phe Arg
1550 1555 1560Asn Tyr Lys Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln
Lys Ser 1565 1570 1575Leu Glu Thr Leu Asn Thr Ala Ala Thr Lys Val
His Pro Val Ile 1580 1585 1590Pro Ala Met Trp Leu Glu Asp Gln Val
Cys Phe Leu Leu Lys Leu 1595 1600 1605Met Leu Gln Gln Cys Lys Thr
Gln Tyr Glu Leu Gly Lys Leu Leu 1610 1615 1620Gln Leu Phe Val Glu
Arg Glu His Leu Phe Ser Asp Gly Pro Asp 1625 1630 1635Val Lys Lys
Leu Cys Ile Leu Cys Gln Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile
Ala Ile Asn His Thr Ile Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660
1665Leu Gln His Glu Cys Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp
1670 1675 1680Gly Gln Phe Ala Leu Ala Arg Arg Val Ala Glu Leu Ala
Glu Leu 1685 1690 1695Pro Val Asp Asn Leu Val Ile Lys Glu Ile Thr
Gln Glu Met Gln 1700 1705 1710Thr Leu Lys His Ile Glu Gln Trp Ser
Leu Lys Gln Ala Arg Ile 1715 1720 1725Asp Phe Trp Lys Lys Cys His
Glu Asn Phe Lys Lys Asn Ser Ile 1730 1735 1740Ser Ser Lys Ala Ala
Ser Ser Phe Phe Ser Thr Gln Ala His Val 1745 1750 1755Ala Cys Glu
His Pro Thr Gly Trp Ser Ser Met Glu Glu Arg His 1760 1765 1770Leu
Leu Leu Thr Leu Ala Gly His Trp Leu Ala Gln Glu Asp Val 1775 1780
1785Val Pro Leu Asp Lys Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu
1790 1795 1800Cys Arg Ile Thr Gln His Thr Leu Gly Arg Asn Gln Glu
Glu Thr 1805 1810 1815Glu Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser
Gly Glu Leu Ser 1820 1825 1830Phe Asp Ser Leu Ala Ser Glu Phe Ser
Phe Ser Val Gly Cys Ser 1835 1840 1845Glu His Ile Lys Ile Leu Arg
Thr 1850 18551801949PRTHomo sapiens 180Met Ala Ala Glu Glu Gly Val
Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met
Gly Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala
Met Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu
Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser
Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu
Gly Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90
95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu
100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp
Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys
Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu
Arg Ile Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe
Ile Asn Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg
Asp Ala Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu
Pro Ala Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys
Arg Gly Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215
220Phe Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala
Leu225 230 235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu
Pro Ala Lys Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln
Asp Leu Asp Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala
Val Ala Leu Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly
His Leu Leu Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln
Gly Pro Lys Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser
Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330
335Ser Trp Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser
340 345 350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile
Leu His 355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser
Val Gln Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly
Gln Tyr Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser
Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln
Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe
Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr
Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455
460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln
Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile
Leu Phe Gly
Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly
Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp
Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile
Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser
Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val
Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg
Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585
590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu
595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile
Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu
Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu
Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp
Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val
Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val
Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln
Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710
715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys
Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly
Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr
Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys
Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp
Phe Val His Gln Val Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe
Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile
Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser 820 825
830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg
835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln
Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys
Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala
Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe
Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp
Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr Ser Cys
Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg
Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950
955 960Leu Leu Arg Leu Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu
Pro 965 970 975Val Gln Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His
Ser Gln Phe 980 985 990Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His
Leu Leu Tyr Val Tyr 995 1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro
Glu Asn Cys Pro Phe Leu Glu 1010 1015 1020Lys Lys Glu Leu His Glu
Ala His Pro Trp Phe Glu Phe Leu Val 1025 1030 1035Gln Cys Arg Gln
Val Ala Ser Asn Leu Thr Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln
Ala Ser Leu Ala Asn Ala Gln Ile Leu Ile Pro Thr Asn 1055 1060
1065Gln Ala Ser Val Ser Ser Met Leu Leu Glu Gly His Thr Leu Leu
1070 1075 1080Ala Leu Ala Thr Thr Met Tyr Ser Pro Gly Gly Val Ser
Gln Val 1085 1090 1095Val Gln Asn Glu Glu Asn Glu Asn Cys Leu Lys
Lys Val Asp Pro 1100 1105 1110Gln Leu Leu Lys Met Ala Leu Thr Pro
Tyr Pro Lys Leu Lys Thr 1115 1120 1125Ala Leu Phe Pro Gln Cys Thr
Pro Pro Ser Val Leu Pro Ser Asp 1130 1135 1140Ile Thr Ile Tyr His
Leu Ile Gln Ser Leu Ser Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu
Phe Gly Trp Gln Ser Ala Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp
Ala Trp Ser His Leu Pro His Phe Ser Ser Pro Asp Leu Val 1175 1180
1185Asn Lys Tyr Ala Ile Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu
1190 1195 1200His Asn Gly Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu
Val Gln 1205 1210 1215Glu Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu
Ile Gln Gln Val 1220 1225 1230Gly Asn Glu Ala Tyr Val Ile Gly Leu
Ser Ser Phe His Ile Pro 1235 1240 1245Ser Ile Gly Ala Ala Cys Val
Cys Phe Leu Glu Leu Leu Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu
Arg Val Asp Met Lys Val Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr
Lys Cys Arg Asn Glu Asp Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg
Glu Ser Val Ala Glu Lys Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300
1305Lys Thr Thr Thr Glu Glu Leu Leu Val Leu Leu Glu Glu Gly Thr
1310 1315 1320Trp Asn Ser Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser
Ser Glu 1325 1330 1335Ser Ser Ser Gln Trp Ala Leu Val Val Gln Phe
Cys Arg Leu His 1340 1345 1350Asn Met Lys Leu Ser Ile Ser Tyr Leu
Arg Glu Cys Ala Lys Ala 1355 1360 1365Asn Asp Trp Leu Gln Phe Ile
Ile His Ser Gln Leu His Asn Tyr 1370 1375 1380His Pro Ala Glu Val
Lys Ser Leu Ile Gln Tyr Phe Ser Pro Val 1385 1390 1395Ile Gln Asp
His Leu Arg Leu Ala Phe Glu Asn Leu Pro Ser Val 1400 1405 1410Pro
Thr Ser Lys Met Asp Ser Asp Gln Val Cys Asn Lys Cys Pro 1415 1420
1425Gln Glu Leu Gln Gly Ser Lys Gln Glu Met Thr Asp Leu Phe Glu
1430 1435 1440Ile Leu Leu Gln Cys Ser Glu Glu Pro Asp Ser Trp His
Trp Leu 1445 1450 1455Leu Val Glu Ala Val Lys Gln Gln Ala Pro Ile
Leu Ser Val Leu 1460 1465 1470Ala Ser Cys Leu Gln Gly Ala Ser Ala
Ile Ser Cys Leu Cys Val 1475 1480 1485Trp Ile Ile Thr Ser Val Glu
Asp Asn Val Ala Thr Glu Ala Met 1490 1495 1500Gly His Ile Gln Asp
Ser Thr Glu Asp His Thr Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser
Val Ile Trp Arg Thr Leu Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys
Thr Leu Ile Arg Gly Phe Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540
1545Leu Leu Leu Val Met Glu Met Tyr Glu Leu Cys Met Phe Phe Arg
1550 1555 1560Asn Tyr Lys Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln
Lys Ser 1565 1570 1575Leu Glu Thr Leu Asn Thr Ala Ala Thr Lys Val
His Pro Val Ile 1580 1585 1590Pro Ala Met Trp Leu Glu Asp Gln Val
Cys Phe Leu Leu Lys Leu 1595 1600 1605Met Leu Gln Gln Cys Lys Thr
Gln Tyr Glu Leu Gly Lys Leu Leu 1610 1615 1620Gln Leu Phe Val Glu
Arg Glu His Leu Phe Ser Asp Gly Pro Asp 1625 1630 1635Val Lys Lys
Leu Cys Ile Leu Cys Gln Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile
Ala Ile Asn His Thr Ile Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660
1665Leu Gln His Glu Cys Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp
1670 1675 1680Gly Gln Phe Ala Leu Ala Arg Arg Val Ala Glu Leu Ala
Glu Leu 1685 1690 1695Pro Val Asp Asn Leu Val Ile Lys Glu Ile Thr
Gln Glu Met Gln 1700 1705 1710Thr Leu Lys His Ile Glu Gln Trp Ser
Leu Lys Gln Ala Arg Ile 1715 1720 1725Asp Phe Trp Lys Lys Cys His
Glu Asn Phe Lys Lys Asn Ser Ile 1730 1735 1740Ser Ser Lys Ala Ala
Ser Ser Phe Phe Ser Thr Gln Ala His Val 1745 1750 1755Ala Cys Glu
His Pro Thr Gly Trp Ser Ser Met Glu Glu Arg His 1760 1765 1770Leu
Leu Leu Thr Leu Ala Gly His Trp Leu Ala Gln Glu Asp Val 1775 1780
1785Val Pro Leu Asp Lys Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu
1790 1795 1800Cys Arg Ile Thr Gln His Thr Leu Gly Arg Asn Gln Glu
Glu Thr 1805 1810 1815Glu Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser
Gly Glu Leu Ser 1820 1825 1830Phe Asp Ser Leu Ala Ser Glu Phe Ser
Phe Ser Lys Leu Ala Ala 1835 1840 1845Leu Asn Thr Ser Lys Tyr Leu
Glu Leu Asn Ser Leu Pro Ser Lys 1850 1855 1860Glu Thr Cys Glu Asn
Arg Leu Asp Trp Lys Glu Gln Glu Ser Leu 1865 1870 1875Asn Phe Leu
Ile Gly Arg Leu Leu Asp Asp Gly Cys Val His Glu 1880 1885 1890Ala
Ser Arg Val Cys Arg Tyr Phe His Phe Tyr Asn Pro Asp Val 1895 1900
1905Ala Leu Val Leu His Cys Arg Ala Leu Ala Ser Gly Glu Ala Arg
1910 1915 1920Trp Arg Ile Cys Thr Gln Arg Ser Met Leu Ser Tyr Lys
Val Leu 1925 1930 1935Ser Cys Leu Arg Lys Lys His Pro Thr Phe Pro
1940 19451811956PRTHomo sapiens 181Met Ala Ala Glu Glu Gly Val Ala
Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly
Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met
Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala
Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu
Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly
Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr
Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys
Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp
Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu
Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu
Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys
Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn
Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp
Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345
350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His
355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln
Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr
Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro
Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu
Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala
Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr
Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu
Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470
475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly
Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly
Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp
Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile
Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser
Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val
Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg
Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585
590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu
595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile
Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu
Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu
Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp
Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val
Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val
Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln
Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710
715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys
Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly
Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr
Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys
Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp
Phe Val His Gln Val Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe
Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile
Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser 820 825
830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg
835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln
Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys
Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala
Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe
Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp
Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr Ser Cys
Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg
Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950
955 960Leu Leu Arg Leu Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu
Pro 965 970 975Val Gln Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His
Ser Gln Phe 980 985 990Ile
Leu Tyr Cys Leu Glu His Ser Leu Gln His Leu Leu Tyr Val Tyr 995
1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys Pro Phe Leu
Glu 1010 1015 1020Lys Lys Glu Leu His Glu Ala His Pro Trp Phe Glu
Phe Leu Val 1025 1030 1035Gln Cys Arg Gln Val Ala Ser Asn Leu Thr
Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu Ala Asn Ala
Gln Ile Leu Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser Val Ser Ser
Met Leu Leu Glu Gly His Thr Leu Leu 1070 1075 1080Ala Leu Ala Thr
Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val 1085 1090 1095Val Gln
Asn Glu Glu Asn Glu Asn Cys Leu Lys Lys Val Asp Pro 1100 1105
1110Gln Leu Leu Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr
1115 1120 1125Ala Leu Phe Pro Gln Cys Thr Pro Pro Ser Val Leu Pro
Ser Asp 1130 1135 1140Ile Thr Ile Tyr His Leu Ile Gln Ser Leu Ser
Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu Phe Gly Trp Gln Ser Ala
Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp Ala Trp Ser His Leu Pro
His Phe Ser Ser Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr Ala Ile
Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His Asn Gly
Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu Val Gln 1205 1210 1215Glu
Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu Ile Gln Gln Val 1220 1225
1230Gly Asn Glu Ala Tyr Val Ile Gly Leu Ser Ser Phe His Ile Pro
1235 1240 1245Ser Ile Gly Ala Ala Cys Val Cys Phe Leu Glu Leu Leu
Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu Arg Val Asp Met Lys Val
Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr Lys Cys Arg Asn Glu Asp
Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg Glu Ser Val Ala Glu Lys
Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300 1305Lys Thr Thr Thr Glu
Glu Leu Leu Val Leu Leu Glu Glu Gly Thr 1310 1315 1320Trp Asn Ser
Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser Ser Glu 1325 1330 1335Ser
Ser Ser Gln Trp Ala Leu Val Val Gln Phe Cys Arg Leu His 1340 1345
1350Asn Met Lys Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala Lys Ala
1355 1360 1365Asn Asp Trp Leu Gln Phe Ile Ile His Ser Gln Leu His
Asn Tyr 1370 1375 1380His Pro Ala Glu Val Lys Ser Leu Ile Gln Tyr
Phe Ser Pro Val 1385 1390 1395Ile Gln Asp His Leu Arg Leu Ala Phe
Glu Asn Leu Pro Ser Val 1400 1405 1410Pro Thr Ser Lys Met Asp Ser
Asp Gln Val Cys Asn Lys Cys Pro 1415 1420 1425Gln Glu Leu Gln Gly
Ser Lys Gln Glu Met Thr Asp Leu Phe Glu 1430 1435 1440Ile Leu Leu
Gln Cys Ser Glu Glu Pro Asp Ser Trp His Trp Leu 1445 1450 1455Leu
Val Glu Ala Val Lys Gln Gln Ala Pro Ile Leu Ser Val Leu 1460 1465
1470Ala Ser Cys Leu Gln Gly Ala Ser Ala Ile Ser Cys Leu Cys Val
1475 1480 1485Trp Ile Ile Thr Ser Val Glu Asp Asn Val Ala Thr Glu
Ala Met 1490 1495 1500Gly His Ile Gln Asp Ser Thr Glu Asp His Thr
Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser Val Ile Trp Arg Thr Leu
Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys Thr Leu Ile Arg Gly Phe
Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540 1545Leu Leu Leu Val Met
Glu Met Tyr Glu Leu Cys Met Phe Phe Arg 1550 1555 1560Asn Tyr Lys
Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln Lys Ser 1565 1570 1575Leu
Glu Thr Leu Asn Thr Ala Ala Thr Lys Val His Pro Val Ile 1580 1585
1590Pro Ala Met Trp Leu Glu Asp Gln Val Cys Phe Leu Leu Lys Leu
1595 1600 1605Met Leu Gln Gln Cys Lys Thr Gln Tyr Glu Leu Gly Lys
Leu Leu 1610 1615 1620Gln Leu Phe Val Glu Arg Glu His Leu Phe Ser
Asp Gly Pro Asp 1625 1630 1635Val Lys Lys Leu Cys Ile Leu Cys Gln
Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile Ala Ile Asn His Thr Ile
Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660 1665Leu Gln His Glu Cys
Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp 1670 1675 1680Gly Gln Phe
Ala Leu Ala Arg Arg Val Ala Glu Leu Ala Glu Leu 1685 1690 1695Pro
Val Asp Asn Leu Val Ile Lys Glu Ile Thr Gln Glu Met Gln 1700 1705
1710Thr Leu Lys His Ile Glu Gln Trp Ser Leu Lys Gln Ala Arg Ile
1715 1720 1725Asp Phe Trp Lys Lys Cys His Glu Asn Phe Lys Lys Asn
Ser Ile 1730 1735 1740Ser Ser Lys Ala Ala Ser Ser Phe Phe Ser Thr
Gln Ala His Val 1745 1750 1755Ala Cys Glu His Pro Thr Gly Trp Ser
Ser Met Glu Glu Arg His 1760 1765 1770Leu Leu Leu Thr Leu Ala Gly
His Trp Leu Ala Gln Glu Asp Val 1775 1780 1785Val Pro Leu Asp Lys
Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu 1790 1795 1800Cys Arg Ile
Thr Gln His Thr Leu Gly Arg Asn Gln Glu Glu Thr 1805 1810 1815Glu
Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser Gly Glu Leu Ser 1820 1825
1830Phe Asp Ser Leu Ala Ser Glu Phe Ser Phe Ser Lys Leu Ala Ala
1835 1840 1845Leu Asn Thr Ser Lys Tyr Leu Glu Leu Asn Ser Leu Pro
Ser Lys 1850 1855 1860Glu Thr Cys Glu Asn Arg Leu Asp Trp Lys Glu
Gln Glu Ser Leu 1865 1870 1875Asn Phe Leu Ile Gly Arg Leu Leu Asp
Asp Gly Cys Val His Glu 1880 1885 1890Ala Ser Arg Val Cys Arg Tyr
Phe His Phe Tyr Asn Pro Asp Val 1895 1900 1905Ala Leu Val Leu His
Cys Arg Ala Leu Ala Ser Gly Glu Ala Ser 1910 1915 1920Met Glu Asp
Leu His Pro Glu Ile His Ala Leu Leu Gln Ser Ala 1925 1930 1935Glu
Leu Leu Glu Glu Glu Ala Pro Asp Ile Pro Leu Arg Arg Val 1940 1945
1950His Ser Thr 19551821999PRTHomo sapiens 182Met Ala Ala Glu Glu
Gly Val Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala
Ala Met Gly Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala
Glu Ala Met Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln
Pro Glu Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val
Leu Ser Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75
80Glu Gly Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser
85 90 95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr
Glu 100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys
Asp Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln
Lys Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser
Leu Arg Ile Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu
Phe Ile Asn Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu
Arg Asp Ala Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro
Leu Pro Ala Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200
205Cys Arg Gly Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile
210 215 220Phe Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu
Ala Leu225 230 235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln
Glu Pro Ala Lys Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser
Gln Asp Leu Asp Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser
Ala Val Ala Leu Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro
Gly His Leu Leu Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile
Gln Gly Pro Lys Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315
320Ser Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg
325 330 335Ser Trp Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys
Asn Ser 340 345 350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln
Asp Ile Leu His 355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser
Thr Ser Val Gln Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met
His Gly Gln Tyr Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys
Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser
Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr
Gly Phe Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440
445Thr Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser
450 455 460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln
Gln Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu
Ile Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu
Met Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His
Leu Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu
Glu Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe
Phe Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555
560Lys Ser Ser Val Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr
565 570 575Leu Arg Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu
Cys Ser 580 585 590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys
His Phe Ser Glu 595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu
Asn Asn Gln Ile Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu
Asp Glu His Leu Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser
Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp
Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn
Val Pro Lys Val Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680
685Glu Glu Val Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala
690 695 700Gln Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu
Glu Glu705 710 715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp
Asn Leu Lys Lys Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu
Lys Asn Met Gly Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile
Cys Phe Tyr Thr Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val
Glu Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys
Arg Thr Ile Asp Phe Val His Gln Val Glu Lys Leu Tyr785 790 795
800Leu Gly His Phe Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr
805 810 815Trp Ile Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu
Asp Ser 820 825 830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys
Gln Asp His Arg 835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp
Gln Leu Thr Gln Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro
Glu Glu Tyr Lys Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg
Tyr Leu Thr Ala Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp
Ile Gly Glu Phe Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905 910Gln
Gln Asn Lys Trp Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn 915 920
925Thr Ser Cys Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala
930 935 940Arg Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu
Cys Phe945 950 955 960Leu Leu Arg Leu Ser Arg Ile Gly Gly Val Ile
Gln Asp Thr Leu Pro 965 970 975Val Gln Asn Tyr Lys Thr Lys Glu Gly
Trp Asp Phe His Ser Gln Phe 980 985 990Ile Leu Tyr Cys Leu Glu His
Ser Leu Gln His Leu Leu Tyr Val Tyr 995 1000 1005Leu Asp Cys Tyr
Lys Leu Ser Pro Glu Asn Cys Pro Phe Leu Glu 1010 1015 1020Lys Lys
Glu Leu His Glu Ala His Pro Trp Phe Glu Phe Leu Val 1025 1030
1035Gln Cys Arg Gln Val Ala Ser Asn Leu Thr Asp Pro Lys Leu Ile
1040 1045 1050Phe Gln Ala Ser Leu Ala Asn Ala Gln Ile Leu Ile Pro
Thr Asn 1055 1060 1065Gln Ala Ser Val Ser Ser Met Leu Leu Glu Gly
His Thr Leu Leu 1070 1075 1080Ala Leu Ala Thr Thr Met Tyr Ser Pro
Gly Gly Val Ser Gln Val 1085 1090 1095Val Gln Asn Glu Glu Asn Glu
Asn Cys Leu Lys Lys Val Asp Pro 1100 1105 1110Gln Leu Leu Lys Met
Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr 1115 1120 1125Ala Leu Phe
Pro Gln Cys Thr Pro Pro Ser Val Leu Pro Ser Asp 1130 1135 1140Ile
Thr Ile Tyr His Leu Ile Gln Ser Leu Ser Pro Phe Asp Pro 1145 1150
1155Ser Arg Leu Phe Gly Trp Gln Ser Ala Asn Thr Leu Ala Ile Gly
1160 1165 1170Asp Ala Trp Ser His Leu Pro His Phe Ser Ser Pro Asp
Leu Val 1175 1180 1185Asn Lys Tyr Ala Ile Val Glu Arg Leu Asn Phe
Ala Tyr Tyr Leu 1190 1195 1200His Asn Gly Arg Pro Ser Phe Ala Phe
Gly Thr Phe Leu Val Gln 1205 1210 1215Glu Leu Ile Lys Ser Lys Thr
Pro Lys Gln Leu Ile Gln Gln Val 1220 1225 1230Gly Asn Glu Ala Tyr
Val Ile Gly Leu Ser Ser Phe His Ile Pro 1235 1240 1245Ser Ile Gly
Ala Ala Cys Val Cys Phe Leu Glu Leu Leu Gly Leu 1250 1255 1260Asp
Ser Leu Lys Leu Arg Val Asp Met Lys Val Ala Asn Ile Ile 1265 1270
1275Leu Ser Tyr Lys Cys Arg Asn Glu Asp Ala Gln Tyr Ser Phe Ile
1280 1285 1290Arg Glu Ser Val Ala Glu Lys Leu Ser Lys Leu Ala Asp
Gly Glu 1295 1300 1305Lys Thr Thr Thr Glu Glu Leu Leu Val Leu Leu
Glu Glu Gly Thr 1310 1315 1320Trp Asn Ser Ile Gln Gln Gln Glu Ile
Lys Arg Leu Ser Ser Glu 1325 1330 1335Ser Ser Ser Gln Trp Ala Leu
Val Val Gln Phe Cys Arg Leu His 1340 1345 1350Asn Met Lys Leu Ser
Ile Ser Tyr Leu Arg Glu Cys Ala Lys Ala 1355 1360 1365Asn Asp Trp
Leu Gln Phe Ile Ile His Ser Gln Leu His Asn Tyr 1370 1375 1380His
Pro Ala Glu Val Lys Ser Leu Ile Gln Tyr Phe Ser Pro Val 1385 1390
1395Ile Gln Asp His Leu Arg Leu Ala Phe Glu Asn Leu Pro Ser Val
1400 1405 1410Pro Thr Ser Lys Met Asp Ser Asp Gln Val Cys Asn Lys
Cys Pro 1415 1420 1425Gln Glu Leu Gln Gly Ser Lys Gln Glu Met Thr
Asp Leu Phe Glu 1430 1435 1440Ile Leu Leu Gln Cys Ser Glu Glu Pro
Asp Ser Trp His Trp Leu 1445 1450 1455Leu Val Glu Ala Val Lys Gln
Gln Ala Pro Ile Leu Ser Val Leu 1460 1465 1470Ala Ser Cys Leu Gln
Gly Ala Ser Ala Ile Ser Cys Leu Cys Val 1475 1480
1485Trp Ile Ile Thr Ser Val Glu Asp Asn Val Ala Thr Glu Ala Met
1490 1495 1500Gly His Ile Gln Asp Ser Thr Glu Asp His Thr Trp Asn
Leu Glu 1505 1510 1515Asp Leu Ser Val Ile Trp Arg Thr Leu Leu Thr
Arg Gln Lys Ser 1520 1525 1530Lys Thr Leu Ile Arg Gly Phe Gln Leu
Phe Phe Lys Asp Ser Pro 1535 1540 1545Leu Leu Leu Val Met Glu Met
Tyr Glu Leu Cys Met Phe Phe Arg 1550 1555 1560Asn Tyr Lys Glu Ala
Glu Ala Lys Leu Leu Glu Phe Gln Lys Ser 1565 1570 1575Leu Glu Thr
Leu Asn Thr Ala Ala Thr Lys Val His Pro Val Ile 1580 1585 1590Pro
Ala Met Trp Leu Glu Asp Gln Val Cys Phe Leu Leu Lys Leu 1595 1600
1605Met Leu Gln Gln Cys Lys Thr Gln Tyr Glu Leu Gly Lys Leu Leu
1610 1615 1620Gln Leu Phe Val Glu Arg Glu His Leu Phe Ser Asp Gly
Pro Asp 1625 1630 1635Val Lys Lys Leu Cys Ile Leu Cys Gln Ile Leu
Lys Asp Thr Ser 1640 1645 1650Ile Ala Ile Asn His Thr Ile Ile Thr
Ser Tyr Ser Ile Glu Asn 1655 1660 1665Leu Gln His Glu Cys Arg Ser
Ile Leu Glu Arg Leu Gln Thr Asp 1670 1675 1680Gly Gln Phe Ala Leu
Ala Arg Arg Val Ala Glu Leu Ala Glu Leu 1685 1690 1695Pro Val Asp
Asn Leu Val Ile Lys Glu Ile Thr Gln Glu Met Gln 1700 1705 1710Thr
Leu Lys His Ile Glu Gln Trp Ser Leu Lys Gln Ala Arg Ile 1715 1720
1725Asp Phe Trp Lys Lys Cys His Glu Asn Phe Lys Lys Asn Ser Ile
1730 1735 1740Ser Ser Lys Ala Ala Ser Ser Phe Phe Ser Thr Gln Ala
His Val 1745 1750 1755Ala Cys Glu His Pro Thr Gly Trp Ser Ser Met
Glu Glu Arg His 1760 1765 1770Leu Leu Leu Thr Leu Ala Gly His Trp
Leu Ala Gln Glu Asp Val 1775 1780 1785Val Pro Leu Asp Lys Leu Glu
Glu Leu Glu Lys Gln Ile Trp Leu 1790 1795 1800Cys Arg Ile Thr Gln
His Thr Leu Gly Arg Asn Gln Glu Glu Thr 1805 1810 1815Glu Pro Arg
Phe Ser Arg Gln Ile Ser Thr Ser Gly Glu Leu Ser 1820 1825 1830Phe
Asp Ser Leu Ala Ser Glu Phe Ser Phe Ser Lys Leu Ala Ala 1835 1840
1845Leu Asn Thr Ser Lys Tyr Leu Glu Leu Asn Ser Leu Pro Ser Lys
1850 1855 1860Glu Thr Cys Glu Asn Arg Leu Asp Trp Lys Glu Gln Glu
Ser Leu 1865 1870 1875Asn Phe Leu Ile Gly Arg Leu Leu Asp Asp Gly
Cys Val His Glu 1880 1885 1890Ala Ser Arg Val Cys Arg Tyr Phe His
Phe Tyr Asn Pro Asp Val 1895 1900 1905Ala Leu Val Leu His Cys Arg
Ala Leu Ala Ser Gly Glu Ala Ser 1910 1915 1920Met Glu Asp Leu His
Pro Glu Ile His Ala Leu Leu Gln Ser Ala 1925 1930 1935Glu Leu Leu
Glu Glu Glu Ala Pro Asp Ile Pro Leu Arg Arg Val 1940 1945 1950His
Ser Thr Ser Ser Leu Asp Ser Gln Lys Phe Val Thr Val Pro 1955 1960
1965Ser Ser Asn Glu Val Val Thr Asn Leu Glu Val Leu Thr Ser Lys
1970 1975 1980Cys Leu His Gly Lys Asn Tyr Cys Arg Gln Val Leu Ser
Leu Ser 1985 1990 1995Val1831998PRTHomo sapiens 183Met Ala Ala Glu
Glu Gly Val Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr
Ala Ala Met Gly Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro
Ala Glu Ala Met Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr
Gln Pro Glu Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55
60Val Leu Ser Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65
70 75 80Glu Gly Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser
Ser 85 90 95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn
Tyr Glu 100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg
Cys Asp Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu
Gln Lys Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu
Ser Leu Arg Ile Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu
Leu Phe Ile Asn Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro
Glu Arg Asp Ala Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu
Pro Leu Pro Ala Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200
205Cys Arg Gly Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile
210 215 220Phe Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu
Ala Leu225 230 235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln
Glu Pro Ala Lys Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser
Gln Asp Leu Asp Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser
Ala Val Ala Leu Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro
Gly His Leu Leu Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile
Gln Gly Pro Lys Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315
320Ser Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg
325 330 335Ser Trp Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys
Asn Ser 340 345 350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln
Asp Ile Leu His 355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser
Thr Ser Val Gln Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met
His Gly Gln Tyr Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys
Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser
Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr
Gly Phe Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440
445Thr Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser
450 455 460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln
Gln Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu
Ile Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu
Met Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His
Leu Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu
Glu Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe
Phe Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555
560Lys Ser Ser Val Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr
565 570 575Leu Arg Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu
Cys Ser 580 585 590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys
His Phe Ser Glu 595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu
Asn Asn Gln Ile Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu
Asp Glu His Leu Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser
Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp
Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn
Val Pro Lys Val Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680
685Glu Glu Val Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala
690 695 700Gln Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu
Glu Glu705 710 715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp
Asn Leu Lys Lys Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu
Lys Asn Met Gly Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile
Cys Phe Tyr Thr Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val
Glu Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys
Arg Thr Ile Asp Phe Val His Gln Val Glu Lys Leu Tyr785 790 795
800Leu Gly His Phe Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr
805 810 815Trp Ile Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu
Asp Ser 820 825 830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys
Gln Asp His Arg 835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp
Gln Leu Thr Gln Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro
Glu Glu Tyr Lys Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg
Tyr Leu Thr Ala Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp
Ile Gly Glu Phe Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905 910Gln
Gln Asn Lys Trp Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn 915 920
925Thr Ser Cys Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala
930 935 940Arg Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu
Cys Phe945 950 955 960Leu Leu Arg Leu Ser Arg Ile Gly Gly Val Ile
Gln Asp Thr Leu Pro 965 970 975Val Gln Asn Tyr Lys Thr Lys Glu Gly
Trp Asp Phe His Ser Gln Phe 980 985 990Ile Leu Tyr Cys Leu Glu His
Ser Leu Gln His Leu Leu Tyr Val Tyr 995 1000 1005Leu Asp Cys Tyr
Lys Leu Ser Pro Glu Asn Cys Pro Phe Leu Glu 1010 1015 1020Lys Lys
Glu Leu His Glu Ala His Pro Trp Phe Glu Phe Leu Val 1025 1030
1035Gln Cys Arg Gln Val Ala Ser Asn Leu Thr Asp Pro Lys Leu Ile
1040 1045 1050Phe Gln Ala Ser Leu Ala Asn Ala Gln Ile Leu Ile Pro
Thr Asn 1055 1060 1065Gln Ala Ser Val Ser Ser Met Leu Leu Glu Gly
His Thr Leu Leu 1070 1075 1080Ala Leu Ala Thr Thr Met Tyr Ser Pro
Gly Gly Val Ser Gln Val 1085 1090 1095Val Gln Asn Glu Glu Asn Glu
Asn Cys Leu Lys Lys Val Asp Pro 1100 1105 1110Gln Leu Leu Lys Met
Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr 1115 1120 1125Ala Leu Phe
Pro Gln Cys Thr Pro Pro Ser Val Leu Pro Ser Asp 1130 1135 1140Ile
Thr Ile Tyr His Leu Ile Gln Ser Leu Ser Pro Phe Asp Pro 1145 1150
1155Ser Arg Leu Phe Gly Trp Gln Ser Ala Asn Thr Leu Ala Ile Gly
1160 1165 1170Asp Ala Trp Ser His Leu Pro His Phe Ser Ser Pro Asp
Leu Val 1175 1180 1185Asn Lys Tyr Ala Ile Val Glu Arg Leu Asn Phe
Ala Tyr Tyr Leu 1190 1195 1200His Asn Gly Arg Pro Ser Phe Ala Phe
Gly Thr Phe Leu Val Gln 1205 1210 1215Glu Leu Ile Lys Ser Lys Thr
Pro Lys Gln Leu Ile Gln Gln Val 1220 1225 1230Gly Asn Glu Ala Tyr
Val Ile Gly Leu Ser Ser Phe His Ile Pro 1235 1240 1245Ser Ile Gly
Ala Ala Cys Val Cys Phe Leu Glu Leu Leu Gly Leu 1250 1255 1260Asp
Ser Leu Lys Leu Arg Val Asp Met Lys Val Ala Asn Ile Ile 1265 1270
1275Leu Ser Tyr Lys Cys Arg Asn Glu Asp Ala Gln Tyr Ser Phe Ile
1280 1285 1290Arg Glu Ser Val Ala Glu Lys Leu Ser Lys Leu Ala Asp
Gly Glu 1295 1300 1305Lys Thr Thr Thr Glu Glu Leu Leu Val Leu Leu
Glu Glu Gly Thr 1310 1315 1320Trp Asn Ser Ile Gln Gln Gln Glu Ile
Lys Arg Leu Ser Ser Glu 1325 1330 1335Ser Ser Ser Gln Trp Ala Leu
Val Val Gln Phe Cys Arg Leu His 1340 1345 1350Asn Met Lys Leu Ser
Ile Ser Tyr Leu Arg Glu Cys Ala Lys Ala 1355 1360 1365Asn Asp Trp
Leu Gln Phe Ile Ile His Ser Gln Leu His Asn Tyr 1370 1375 1380His
Pro Ala Glu Val Lys Ser Leu Ile Gln Tyr Phe Ser Pro Val 1385 1390
1395Ile Gln Asp His Leu Arg Leu Ala Phe Glu Asn Leu Pro Ser Val
1400 1405 1410Pro Thr Ser Lys Met Asp Ser Asp Gln Val Cys Asn Lys
Cys Pro 1415 1420 1425Gln Glu Leu Gln Gly Ser Lys Gln Glu Met Thr
Asp Leu Phe Glu 1430 1435 1440Ile Leu Leu Gln Cys Ser Glu Glu Pro
Asp Ser Trp His Trp Leu 1445 1450 1455Leu Val Glu Ala Val Lys Gln
Gln Ala Pro Ile Leu Ser Val Leu 1460 1465 1470Ala Ser Cys Leu Gln
Gly Ala Ser Ala Ile Ser Cys Leu Cys Val 1475 1480 1485Trp Ile Ile
Thr Ser Val Glu Asp Asn Val Ala Thr Glu Ala Met 1490 1495 1500Gly
His Ile Gln Asp Ser Thr Glu Asp His Thr Trp Asn Leu Glu 1505 1510
1515Asp Leu Ser Val Ile Trp Arg Thr Leu Leu Thr Arg Gln Lys Ser
1520 1525 1530Lys Thr Leu Ile Arg Gly Phe Gln Leu Phe Phe Lys Asp
Ser Pro 1535 1540 1545Leu Leu Leu Val Met Glu Met Tyr Glu Leu Cys
Met Phe Phe Arg 1550 1555 1560Asn Tyr Lys Glu Ala Glu Ala Lys Leu
Leu Glu Phe Gln Lys Ser 1565 1570 1575Leu Glu Thr Leu Asn Thr Ala
Ala Thr Lys Val His Pro Val Ile 1580 1585 1590Pro Ala Met Trp Leu
Glu Asp Gln Val Cys Phe Leu Leu Lys Leu 1595 1600 1605Met Leu Gln
Gln Cys Lys Thr Gln Tyr Glu Leu Gly Lys Leu Leu 1610 1615 1620Gln
Leu Phe Val Glu Arg Glu His Leu Phe Ser Asp Gly Pro Asp 1625 1630
1635Val Lys Lys Leu Cys Ile Leu Cys Gln Ile Leu Lys Asp Thr Ser
1640 1645 1650Ile Ala Ile Asn His Thr Ile Ile Thr Ser Tyr Ser Ile
Glu Asn 1655 1660 1665Leu Gln His Glu Cys Arg Ser Ile Leu Glu Arg
Leu Gln Thr Asp 1670 1675 1680Gly Gln Phe Ala Leu Ala Arg Arg Val
Ala Glu Leu Ala Glu Leu 1685 1690 1695Pro Val Asp Asn Leu Val Ile
Lys Glu Ile Thr Gln Glu Met Gln 1700 1705 1710Thr Leu Lys His Ile
Glu Gln Trp Ser Leu Lys Gln Ala Arg Ile 1715 1720 1725Asp Phe Trp
Lys Lys Cys His Glu Asn Phe Lys Lys Asn Ser Ile 1730 1735 1740Ser
Ser Lys Ala Ala Ser Ser Phe Phe Ser Thr Gln Ala His Val 1745 1750
1755Ala Cys Glu His Pro Thr Gly Trp Ser Ser Met Glu Glu Arg His
1760 1765 1770Leu Leu Leu Thr Leu Ala Gly His Trp Leu Ala Gln Glu
Asp Val 1775 1780 1785Val Pro Leu Asp Lys Leu Glu Glu Leu Glu Lys
Gln Ile Trp Leu 1790 1795 1800Cys Arg Ile Thr Gln His Thr Leu Gly
Arg Asn Gln Glu Glu Thr 1805 1810 1815Glu Pro Arg Phe Ser Arg Gln
Ile Ser Thr Ser Gly Glu Leu Ser 1820 1825 1830Phe Asp Ser Leu Ala
Ser Glu Phe Ser Phe Ser Lys Leu Ala Ala 1835 1840 1845Leu Asn Thr
Ser Lys Tyr Leu Glu Leu Asn Ser Leu Pro Ser Lys 1850 1855 1860Glu
Thr Cys Glu Asn Arg Leu Asp Trp Lys Glu Gln Glu Ser Leu 1865 1870
1875Asn Phe Leu Ile Gly Arg Leu Leu Asp Asp Gly Cys Val His Glu
1880 1885 1890Ala Ser Arg Val Cys Arg Tyr Phe His Phe Tyr Asn Pro
Asp Val 1895 1900 1905Ala Leu Val Leu His Cys Arg Ala Leu Ala Ser
Gly Glu Ala Ser 1910 1915 1920Met Glu Asp Leu His Pro Glu Ile His
Ala Leu Leu Gln Ser Ala
1925 1930 1935Glu Leu Leu Glu Glu Glu Ala Pro Asp Ile Pro Leu Arg
Arg Val 1940 1945 1950His Ser Thr Ser Ser Leu Asp Ser Gln Lys Phe
Val Thr Val Pro 1955 1960 1965Ser Ser Asn Glu Val Val Thr Asn Leu
Glu Val Leu Thr Ser Lys 1970 1975 1980Cys Leu His Gly Lys Asn Tyr
Cys Arg Gln Val Leu Leu Ser Val 1985 1990 19951842055PRTHomo
sapiens 184Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala Gly
Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met Leu
Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser Arg
Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr Ala
Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg Gly
Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe Leu
Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro Lys
Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr Glu
Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu Tyr
Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135 140Gln
Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe His145 150
155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val Ile Leu His
Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg Val Leu Asn
Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val Asp Met Ile
Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe Val Leu Ser
Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val Asp Gly Thr
Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His Lys Glu Asp
Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250 255Ser Ser
Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val 260 265
270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn Leu Tyr
275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg Ile Leu
Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp Glu Asp
Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu Ala Lys
Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln Leu Ser
Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu Val Ser
Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu Glu Ser
Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375 380Ala
Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu Gln385 390
395 400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile
Met 405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys
Val Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr Trp Glu Val
Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp Leu Glu Thr
Gln Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys Cys Ile Pro
Val Asp Ser Ser Gly Asp Gln Gln Leu465 470 475 480Cys Phe Val Leu
Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490 495Thr Gln
Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser 500 505
510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys Ser Ile
515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg Gln Leu
Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn Leu Phe
Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln Phe Asp
His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu Glu Leu
Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg Glu Ser
Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln Leu Leu
Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615 620Leu
Phe Ile His Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly Val625 630
635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile
Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp
Val His Glu 660 665 670Asn Val Pro Lys Val Lys Glu Ser Asn Ile Trp
Lys Lys Leu Ser Phe 675 680 685Glu Glu Val Ile Ala Ser Ala Ile Leu
Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln Thr Phe Phe Arg Ile Asp
Ser His Ser Ala Gln Lys Leu Glu Glu705 710 715 720Leu Ile Gly Ile
Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730 735Asn Ile
Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val 740 745
750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys Asn Ile
755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn Tyr Phe
Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp Phe Val His Gln Val
Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn Met Gln
Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln Asp Phe
Phe Lys His Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys Tyr Asp
Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile Val Leu
Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855 860Ile
Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser Pro865 870
875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp Trp Leu Asn
Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln His Ser Tyr
Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp Pro Leu Leu Thr Val Asp
Val Ile Asn Gln Asn 915 920 925Thr Ser Cys Asn Asn Tyr Met Arg Asn
Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg Asn Gly Val Phe Leu Ala
Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950 955 960Leu Leu Arg Leu
Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu Pro 965 970 975Val Gln
Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His Ser Gln Phe 980 985
990Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His Leu Leu Tyr Val Tyr
995 1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys Pro Phe
Leu Glu 1010 1015 1020Lys Lys Glu Leu His Glu Ala His Pro Trp Phe
Glu Phe Leu Val 1025 1030 1035Gln Cys Arg Gln Val Ala Ser Asn Leu
Thr Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu Ala Asn
Ala Gln Ile Leu Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser Val Ser
Ser Met Leu Leu Glu Gly His Thr Leu Leu 1070 1075 1080Ala Leu Ala
Thr Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val 1085 1090 1095Val
Gln Asn Glu Glu Asn Glu Asn Cys Leu Lys Lys Val Asp Pro 1100 1105
1110Gln Leu Leu Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr
1115 1120 1125Ala Leu Phe Pro Gln Cys Thr Pro Pro Ser Val Leu Pro
Ser Asp 1130 1135 1140Ile Thr Ile Tyr His Leu Ile Gln Ser Leu Ser
Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu Phe Gly Trp Gln Ser Ala
Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp Ala Trp Ser His Leu Pro
His Phe Ser Ser Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr Ala Ile
Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His Asn Gly
Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu Val Gln 1205 1210 1215Glu
Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu Ile Gln Gln Val 1220 1225
1230Gly Asn Glu Ala Tyr Val Ile Gly Leu Ser Ser Phe His Ile Pro
1235 1240 1245Ser Ile Gly Ala Ala Cys Val Cys Phe Leu Glu Leu Leu
Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu Arg Val Asp Met Lys Val
Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr Lys Cys Arg Asn Glu Asp
Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg Glu Ser Val Ala Glu Lys
Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300 1305Lys Thr Thr Thr Glu
Glu Leu Leu Val Leu Leu Glu Glu Gly Thr 1310 1315 1320Trp Asn Ser
Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser Ser Glu 1325 1330 1335Ser
Ser Ser Gln Trp Ala Leu Val Val Gln Phe Cys Arg Leu His 1340 1345
1350Asn Met Lys Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala Lys Ala
1355 1360 1365Asn Asp Trp Leu Gln Phe Ile Ile His Ser Gln Leu His
Asn Tyr 1370 1375 1380His Pro Ala Glu Val Lys Ser Leu Ile Gln Tyr
Phe Ser Pro Val 1385 1390 1395Ile Gln Asp His Leu Arg Leu Ala Phe
Glu Asn Leu Pro Ser Val 1400 1405 1410Pro Thr Ser Lys Met Asp Ser
Asp Gln Val Cys Asn Lys Cys Pro 1415 1420 1425Gln Glu Leu Gln Gly
Ser Lys Gln Glu Met Thr Asp Leu Phe Glu 1430 1435 1440Ile Leu Leu
Gln Cys Ser Glu Glu Pro Asp Ser Trp His Trp Leu 1445 1450 1455Leu
Val Glu Ala Val Lys Gln Gln Ala Pro Ile Leu Ser Val Leu 1460 1465
1470Ala Ser Cys Leu Gln Gly Ala Ser Ala Ile Ser Cys Leu Cys Val
1475 1480 1485Trp Ile Ile Thr Ser Val Glu Asp Asn Val Ala Thr Glu
Ala Met 1490 1495 1500Gly His Ile Gln Asp Ser Thr Glu Asp His Thr
Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser Val Ile Trp Arg Thr Leu
Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys Thr Leu Ile Arg Gly Phe
Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540 1545Leu Leu Leu Val Met
Glu Met Tyr Glu Leu Cys Met Phe Phe Arg 1550 1555 1560Asn Tyr Lys
Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln Lys Ser 1565 1570 1575Leu
Glu Thr Leu Asn Thr Ala Ala Thr Lys Val His Pro Val Ile 1580 1585
1590Pro Ala Met Trp Leu Glu Asp Gln Val Cys Phe Leu Leu Lys Leu
1595 1600 1605Met Leu Gln Gln Cys Lys Thr Gln Tyr Glu Leu Gly Lys
Leu Leu 1610 1615 1620Gln Leu Phe Val Glu Arg Glu His Leu Phe Ser
Asp Gly Pro Asp 1625 1630 1635Val Lys Lys Leu Cys Ile Leu Cys Gln
Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile Ala Ile Asn His Thr Ile
Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660 1665Leu Gln His Glu Cys
Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp 1670 1675 1680Gly Gln Phe
Ala Leu Ala Arg Arg Val Ala Glu Leu Ala Glu Leu 1685 1690 1695Pro
Val Asp Asn Leu Val Ile Lys Glu Ile Thr Gln Glu Met Gln 1700 1705
1710Thr Leu Lys His Ile Glu Gln Trp Ser Leu Lys Gln Ala Arg Ile
1715 1720 1725Asp Phe Trp Lys Lys Cys His Glu Asn Phe Lys Lys Asn
Ser Ile 1730 1735 1740Ser Ser Lys Ala Ala Ser Ser Phe Phe Ser Thr
Gln Ala His Val 1745 1750 1755Ala Cys Glu His Pro Thr Gly Trp Ser
Ser Met Glu Glu Arg His 1760 1765 1770Leu Leu Leu Thr Leu Ala Gly
His Trp Leu Ala Gln Glu Asp Val 1775 1780 1785Val Pro Leu Asp Lys
Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu 1790 1795 1800Cys Arg Ile
Thr Gln His Thr Leu Gly Arg Asn Gln Glu Glu Thr 1805 1810 1815Glu
Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser Gly Glu Leu Ser 1820 1825
1830Phe Asp Ser Leu Ala Ser Glu Phe Ser Phe Ser Lys Leu Ala Ala
1835 1840 1845Leu Asn Thr Ser Lys Tyr Leu Glu Leu Asn Ser Leu Pro
Ser Lys 1850 1855 1860Glu Thr Cys Glu Asn Arg Leu Asp Trp Lys Glu
Gln Glu Ser Leu 1865 1870 1875Asn Phe Leu Ile Gly Arg Leu Leu Asp
Asp Gly Cys Val His Glu 1880 1885 1890Ala Ser Arg Val Cys Arg Tyr
Phe His Phe Tyr Asn Pro Asp Val 1895 1900 1905Ala Leu Val Leu His
Cys Arg Ala Leu Ala Ser Gly Glu Ala Ser 1910 1915 1920Met Glu Asp
Leu His Pro Glu Ile His Ala Leu Leu Gln Ser Ala 1925 1930 1935Glu
Leu Leu Glu Glu Glu Ala Pro Asp Ile Pro Leu Arg Arg Val 1940 1945
1950His Ser Thr Ser Ser Leu Asp Ser Gln Lys Phe Val Thr Val Pro
1955 1960 1965Ser Ser Asn Glu Val Val Thr Asn Leu Glu Val Leu Thr
Ser Lys 1970 1975 1980Cys Leu His Gly Lys Asn Tyr Cys Arg Gln Val
Leu Cys Met Ile 1985 1990 1995Leu Pro Arg Ser Trp Ala Val Pro Thr
Gln Met Leu Leu Leu Arg 2000 2005 2010Met Val Lys Pro Cys Ser Gly
Lys Ser Trp Pro Leu Ser Ser Leu 2015 2020 2025Thr Asp Ala Asn Glu
Pro Arg Pro Ser Ser Ala His Arg Ala Leu 2030 2035 2040Ser Gln Ile
Leu Trp Leu Asn Ser Trp Gln Lys Arg 2045 2050 20551852030PRTHomo
sapiens 185Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala Gly
Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met Leu
Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser Arg
Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr Ala
Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg Gly
Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe Leu
Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro Lys
Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr Glu
Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu Tyr
Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135 140Gln
Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe His145 150
155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val Ile Leu His
Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg Val Leu Asn
Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val Asp Met Ile
Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe Val Leu Ser
Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val Asp Gly Thr
Tyr Val Ala His Val Asp Leu Ala Leu225 230 235 240His Lys Glu Asp
Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250 255Ser Ser
Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val 260 265
270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn Leu Tyr
275 280 285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg Ile Leu
Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp Glu Asp
Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu Ala Lys
Phe Ser Phe Gln Ile Asp
Arg 325 330 335Ser Trp Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile
Lys Asn Ser 340 345 350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe
Gln Asp Ile Leu His 355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His
Ser Thr Ser Val Gln Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile
Met His Gly Gln Tyr Asn Val Leu Gln385 390 395 400Lys Asp His Ala
Lys Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile
Ser Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val 420 425
430Thr Gly Phe Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr
435 440 445Thr Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys
Ser Ser 450 455 460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly
Asp Gln Gln Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu
Ser Leu Ile Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn
Arg Leu Met Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp Thr Leu
Cys His Leu Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro Ile His
Ala Leu Glu Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535 540Val
Asn Phe Phe Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550
555 560Lys Ser Ser Val Ser Asp Gln Phe Asp His Leu Ser Ser His Leu
Tyr 565 570 575Leu Arg Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu
Leu Cys Ser 580 585 590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser
Lys His Phe Ser Glu 595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe
Leu Asn Asn Gln Ile Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu
Leu Asp Glu His Leu Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr
Ser Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro
Trp Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp Val His Glu 660 665
670Asn Val Pro Lys Val Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe
675 680 685Glu Glu Val Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro
Glu Ala 690 695 700Gln Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln
Lys Leu Glu Glu705 710 715 720Leu Ile Gly Ile Gly Leu Asn Leu Val
Phe Asp Asn Leu Lys Lys Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu
Leu Leu Lys Asn Met Gly Phe Asp Val 740 745 750Lys Gly Gln Leu Leu
Lys Ile Cys Phe Tyr Thr Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe
Leu Val Glu Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys
Glu Lys Arg Thr Ile Asp Phe Val His Gln Val Glu Lys Leu Tyr785 790
795 800Leu Gly His Phe Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg
Tyr 805 810 815Trp Ile Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val
Leu Asp Ser 820 825 830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn
Lys Gln Asp His Arg 835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp
Asp Gln Leu Thr Gln Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser
Pro Glu Glu Tyr Lys Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp
Arg Tyr Leu Thr Ala Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu
Trp Ile Gly Glu Phe Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905
910Gln Gln Asn Lys Trp Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn
915 920 925Thr Ser Cys Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys
Leu Ala 930 935 940Arg Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp
Phe Glu Cys Phe945 950 955 960Leu Leu Arg Leu Ser Arg Ile Gly Gly
Val Ile Gln Asp Thr Leu Pro 965 970 975Val Gln Asn Tyr Lys Thr Lys
Glu Gly Trp Asp Phe His Ser Gln Phe 980 985 990Ile Leu Tyr Cys Leu
Glu His Ser Leu Gln His Leu Leu Tyr Val Tyr 995 1000 1005Leu Asp
Cys Tyr Lys Leu Ser Pro Glu Asn Cys Pro Phe Leu Glu 1010 1015
1020Lys Lys Glu Leu His Glu Ala His Pro Trp Phe Glu Phe Leu Val
1025 1030 1035Gln Cys Arg Gln Val Ala Ser Asn Leu Thr Asp Pro Lys
Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu Ala Asn Ala Gln Ile Leu
Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser Val Ser Ser Met Leu Leu
Glu Gly His Thr Leu Leu 1070 1075 1080Ala Leu Ala Thr Thr Met Tyr
Ser Pro Gly Gly Val Ser Gln Val 1085 1090 1095Val Gln Asn Glu Glu
Asn Glu Asn Cys Leu Lys Lys Val Asp Pro 1100 1105 1110Gln Leu Leu
Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr 1115 1120 1125Ala
Leu Phe Pro Gln Cys Thr Pro Pro Ser Val Leu Pro Ser Asp 1130 1135
1140Ile Thr Ile Tyr His Leu Ile Gln Ser Leu Ser Pro Phe Asp Pro
1145 1150 1155Ser Arg Leu Phe Gly Trp Gln Ser Ala Asn Thr Leu Ala
Ile Gly 1160 1165 1170Asp Ala Trp Ser His Leu Pro His Phe Ser Ser
Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr Ala Ile Val Glu Arg Leu
Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His Asn Gly Arg Pro Ser Phe
Ala Phe Gly Thr Phe Leu Val Gln 1205 1210 1215Glu Leu Ile Lys Ser
Lys Thr Pro Lys Gln Leu Ile Gln Gln Val 1220 1225 1230Gly Asn Glu
Ala Tyr Val Ile Gly Leu Ser Ser Phe His Ile Pro 1235 1240 1245Ser
Ile Gly Ala Ala Cys Val Cys Phe Leu Glu Leu Leu Gly Leu 1250 1255
1260Asp Ser Leu Lys Leu Arg Val Asp Met Lys Val Ala Asn Ile Ile
1265 1270 1275Leu Ser Tyr Lys Cys Arg Asn Glu Asp Ala Gln Tyr Ser
Phe Ile 1280 1285 1290Arg Glu Ser Val Ala Glu Lys Leu Ser Lys Leu
Ala Asp Gly Glu 1295 1300 1305Lys Thr Thr Thr Glu Glu Leu Leu Val
Leu Leu Glu Glu Gly Thr 1310 1315 1320Trp Asn Ser Ile Gln Gln Gln
Glu Ile Lys Arg Leu Ser Ser Glu 1325 1330 1335Ser Ser Ser Gln Trp
Ala Leu Val Val Gln Phe Cys Arg Leu His 1340 1345 1350Asn Met Lys
Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala Lys Ala 1355 1360 1365Asn
Asp Trp Leu Gln Phe Ile Ile His Ser Gln Leu His Asn Tyr 1370 1375
1380His Pro Ala Glu Val Lys Ser Leu Ile Gln Tyr Phe Ser Pro Val
1385 1390 1395Ile Gln Asp His Leu Arg Leu Ala Phe Glu Asn Leu Pro
Ser Val 1400 1405 1410Pro Thr Ser Lys Met Asp Ser Asp Gln Val Cys
Asn Lys Cys Pro 1415 1420 1425Gln Glu Leu Gln Gly Ser Lys Gln Glu
Met Thr Asp Leu Phe Glu 1430 1435 1440Ile Leu Leu Gln Cys Ser Glu
Glu Pro Asp Ser Trp His Trp Leu 1445 1450 1455Leu Val Glu Ala Val
Lys Gln Gln Ala Pro Ile Leu Ser Val Leu 1460 1465 1470Ala Ser Cys
Leu Gln Gly Ala Ser Ala Ile Ser Cys Leu Cys Val 1475 1480 1485Trp
Ile Ile Thr Ser Val Glu Asp Asn Val Ala Thr Glu Ala Met 1490 1495
1500Gly His Ile Gln Asp Ser Thr Glu Asp His Thr Trp Asn Leu Glu
1505 1510 1515Asp Leu Ser Val Ile Trp Arg Thr Leu Leu Thr Arg Gln
Lys Ser 1520 1525 1530Lys Thr Leu Ile Arg Gly Phe Gln Leu Phe Phe
Lys Asp Ser Pro 1535 1540 1545Leu Leu Leu Val Met Glu Met Tyr Glu
Leu Cys Met Phe Phe Arg 1550 1555 1560Asn Tyr Lys Glu Ala Glu Ala
Lys Leu Leu Glu Phe Gln Lys Ser 1565 1570 1575Leu Glu Thr Leu Asn
Thr Ala Ala Thr Lys Val His Pro Val Ile 1580 1585 1590Pro Ala Met
Trp Leu Glu Asp Gln Val Cys Phe Leu Leu Lys Leu 1595 1600 1605Met
Leu Gln Gln Cys Lys Thr Gln Tyr Glu Leu Gly Lys Leu Leu 1610 1615
1620Gln Leu Phe Val Glu Arg Glu His Leu Phe Ser Asp Gly Pro Asp
1625 1630 1635Val Lys Lys Leu Cys Ile Leu Cys Gln Ile Leu Lys Asp
Thr Ser 1640 1645 1650Ile Ala Ile Asn His Thr Ile Ile Thr Ser Tyr
Ser Ile Glu Asn 1655 1660 1665Leu Gln His Glu Cys Arg Ser Ile Leu
Glu Arg Leu Gln Thr Asp 1670 1675 1680Gly Gln Phe Ala Leu Ala Arg
Arg Val Ala Glu Leu Ala Glu Leu 1685 1690 1695Pro Val Asp Asn Leu
Val Ile Lys Glu Ile Thr Gln Glu Met Gln 1700 1705 1710Thr Leu Lys
His Ile Glu Gln Trp Ser Leu Lys Gln Ala Arg Ile 1715 1720 1725Asp
Phe Trp Lys Lys Cys His Glu Asn Phe Lys Lys Asn Ser Ile 1730 1735
1740Ser Ser Lys Ala Ala Ser Ser Phe Phe Ser Thr Gln Ala His Val
1745 1750 1755Ala Cys Glu His Pro Thr Gly Trp Ser Ser Met Glu Glu
Arg His 1760 1765 1770Leu Leu Leu Thr Leu Ala Gly His Trp Leu Ala
Gln Glu Asp Val 1775 1780 1785Val Pro Leu Asp Lys Leu Glu Glu Leu
Glu Lys Gln Ile Trp Leu 1790 1795 1800Cys Arg Ile Thr Gln His Thr
Leu Gly Arg Asn Gln Glu Glu Thr 1805 1810 1815Glu Pro Arg Phe Ser
Arg Gln Ile Ser Thr Ser Gly Glu Leu Ser 1820 1825 1830Phe Asp Ser
Leu Ala Ser Glu Phe Ser Phe Ser Lys Leu Ala Ala 1835 1840 1845Leu
Asn Thr Ser Lys Tyr Leu Glu Leu Asn Ser Leu Pro Ser Lys 1850 1855
1860Glu Thr Cys Glu Asn Arg Leu Asp Trp Lys Glu Gln Glu Ser Leu
1865 1870 1875Asn Phe Leu Ile Gly Arg Leu Leu Asp Asp Gly Cys Val
His Glu 1880 1885 1890Ala Ser Arg Val Cys Arg Tyr Phe His Phe Tyr
Asn Pro Asp Val 1895 1900 1905Ala Leu Val Leu His Cys Arg Ala Leu
Ala Ser Gly Glu Ala Ser 1910 1915 1920Met Glu Asp Leu His Pro Glu
Ile His Ala Leu Leu Gln Ser Ala 1925 1930 1935Glu Leu Leu Glu Glu
Glu Ala Pro Asp Ile Pro Leu Arg Arg Val 1940 1945 1950His Ser Thr
Ser Ser Leu Asp Ser Gln Lys Phe Val Thr Val Pro 1955 1960 1965Ser
Ser Asn Glu Val Val Thr Asn Leu Glu Val Leu Thr Ser Lys 1970 1975
1980Cys Leu His Gly Lys Asn Tyr Cys Arg Gln Val Leu Cys Leu Tyr
1985 1990 1995Asp Leu Ala Lys Glu Leu Gly Cys Ser Tyr Thr Asp Val
Ala Ala 2000 2005 2010Gln Asp Gly Glu Ala Met Leu Arg Lys Ile Leu
Ala Ser Gln Gln 2015 2020 2025Pro Asp 20301862259PRTHomo sapiens
186Met Ala Ala Glu Glu Gly Val Ala Ser Ala Ala Ser Ala Gly Gly Ser1
5 10 15Trp Gly Thr Ala Ala Met Gly Arg Val Leu Pro Met Leu Leu Val
Pro 20 25 30Val Pro Ala Glu Ala Met Gly Gln Leu Gly Ser Arg Ala Gln
Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu Gly Ser Leu Thr Ala Ala Gly
Ser Leu Gln 50 55 60Val Leu Ser Leu Thr Pro Gly Ser Arg Gly Gly Gly
Arg Cys Cys Leu65 70 75 80Glu Gly Pro Phe Trp His Phe Leu Trp Glu
Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro Thr Glu Lys Pro Lys Leu Leu
Ala Leu Gly Glu Asn Tyr Glu 100 105 110Leu Leu Ile Tyr Glu Phe Asn
Leu Lys Asp Gly Arg Cys Asp Ala Thr 115 120 125Ile Leu Tyr Ser Cys
Ser Arg Glu Ala Leu Gln Lys Leu Ile Asp Asp 130 135 140Gln Asp Ile
Ser Ile Ser Leu Leu Ser Leu Arg Ile Leu Ser Phe His145 150 155
160Asn Asn Thr Ser Leu Leu Phe Ile Asn Lys Cys Val Ile Leu His Ile
165 170 175Ile Phe Pro Glu Arg Asp Ala Ala Ile Arg Val Leu Asn Cys
Phe Thr 180 185 190Leu Pro Leu Pro Ala Gln Ala Val Asp Met Ile Ile
Asp Thr Gln Leu 195 200 205Cys Arg Gly Ile Leu Phe Val Leu Ser Ser
Leu Gly Trp Ile Tyr Ile 210 215 220Phe Asp Val Val Asp Gly Thr Tyr
Val Ala His Val Asp Leu Ala Leu225 230 235 240His Lys Glu Asp Met
Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys Ile 245 250 255Ser Ser Phe
Thr Ser Leu Lys Val Ser Gln Asp Leu Asp Val Ala Val 260 265 270Ile
Val Ser Ser Ser Asn Ser Ala Val Ala Leu Asn Leu Asn Leu Tyr 275 280
285Phe Arg Gln His Pro Gly His Leu Leu Cys Glu Arg Ile Leu Glu Asp
290 295 300Leu Pro Ile Gln Gly Pro Lys Gly Val Asp Glu Asp Asp Pro
Val Asn305 310 315 320Ser Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser
Phe Gln Ile Asp Arg 325 330 335Ser Trp Lys Ala Gln Leu Ser Ser Leu
Asn Glu Thr Ile Lys Asn Ser 340 345 350Lys Leu Glu Val Ser Cys Cys
Ala Pro Trp Phe Gln Asp Ile Leu His 355 360 365Leu Glu Ser Pro Glu
Ser Gly Asn His Ser Thr Ser Val Gln Ser Trp 370 375 380Ala Phe Ile
Pro Gln Asp Ile Met His Gly Gln Tyr Asn Val Leu Gln385 390 395
400Lys Asp His Ala Lys Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile Met
405 410 415His Ile Ser Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys Val
Ser Val 420 425 430Thr Gly Phe Thr Ala Leu Phe Thr Trp Glu Val Glu
Arg Met Gly Tyr 435 440 445Thr Ile Thr Leu Trp Asp Leu Glu Thr Gln
Gly Met Gln Cys Ser Ser 450 455 460Leu Gly Thr Lys Cys Ile Pro Val
Asp Ser Ser Gly Asp Gln Gln Leu465 470 475 480Cys Phe Val Leu Thr
Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly Leu 485 490 495Thr Gln Glu
Glu Phe Leu Asn Arg Leu Met Ile His Gly Ser Ala Ser 500 505 510Thr
Val Asp Thr Leu Cys His Leu Asn Gly Trp Gly Arg Cys Ser Ile 515 520
525Pro Ile His Ala Leu Glu Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr
530 535 540Val Asn Phe Phe Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro
Ser Ser545 550 555 560Lys Ser Ser Val Ser Asp Gln Phe Asp His Leu
Ser Ser His Leu Tyr 565 570 575Leu Arg Asn Val Glu Glu Leu Ile Pro
Ala Leu Asp Leu Leu Cys Ser 580 585 590Ala Ile Arg Glu Ser Tyr Ser
Glu Pro Gln Ser Lys His Phe Ser Glu 595 600 605Gln Leu Leu Asn Leu
Thr Leu Ser Phe Leu Asn Asn Gln Ile Lys Glu 610 615 620Leu Phe Ile
His Thr Glu Glu Leu Asp Glu His Leu Gln Lys Gly Val625 630 635
640Asn Ile Leu Thr Ser Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile Lys
645 650 655Phe Pro Trp Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp Val
His Glu 660 665 670Asn Val Pro Lys Val Lys Glu Ser Asn Ile Trp Lys
Lys Leu Ser Phe 675 680 685Glu Glu Val Ile Ala Ser Ala Ile Leu Asn
Asn Lys Ile Pro Glu Ala 690 695 700Gln Thr Phe Phe Arg Ile Asp Ser
His Ser Ala Gln Lys Leu Glu Glu705 710 715 720Leu Ile Gly Ile Gly
Leu Asn Leu Val Phe Asp Asn Leu Lys Lys Asn 725 730 735Asn Ile Lys
Glu Ala Ser Glu Leu Leu Lys Asn Met Gly Phe Asp Val 740 745
750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr Thr Asn Lys Asn Ile
755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys Glu Lys Asn Tyr Phe
Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp Phe Val His Gln Val
Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe Gln Glu Asn Met Gln
Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile Lys Glu Gln Asp Phe
Phe Lys His Lys Ser Val Leu Asp Ser 820 825 830Phe Leu Lys Tyr Asp
Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg 835 840 845Ile Val Leu
Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln Glu Ser 850 855 860Ile
Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys Ser Tyr Ser Pro865 870
875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp Trp Leu Asn
Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln His Ser Tyr
Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp Pro Leu Leu Thr Val Asp
Val Ile Asn Gln Asn 915 920 925Thr Ser Cys Asn Asn Tyr Met Arg Asn
Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg Asn Gly Val Phe Leu Ala
Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950 955 960Leu Leu Arg Leu
Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu Pro 965 970 975Val Gln
Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His Ser Gln Phe 980 985
990Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His Leu Leu Tyr Val Tyr
995 1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys Pro Phe
Leu Glu 1010 1015 1020Lys Lys Glu Leu His Glu Ala His Pro Trp Phe
Glu Phe Leu Val 1025 1030 1035Gln Cys Arg Gln Val Ala Ser Asn Leu
Thr Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln Ala Ser Leu Ala Asn
Ala Gln Ile Leu Ile Pro Thr Asn 1055 1060 1065Gln Ala Ser Val Ser
Ser Met Leu Leu Glu Gly His Thr Leu Leu 1070 1075 1080Ala Leu Ala
Thr Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val 1085 1090 1095Val
Gln Asn Glu Glu Asn Glu Asn Cys Leu Lys Lys Val Asp Pro 1100 1105
1110Gln Leu Leu Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr
1115 1120 1125Ala Leu Phe Pro Gln Cys Thr Pro Pro Ser Val Leu Pro
Ser Asp 1130 1135 1140Ile Thr Ile Tyr His Leu Ile Gln Ser Leu Ser
Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu Phe Gly Trp Gln Ser Ala
Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp Ala Trp Ser His Leu Pro
His Phe Ser Ser Pro Asp Leu Val 1175 1180 1185Asn Lys Tyr Ala Ile
Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu 1190 1195 1200His Asn Gly
Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu Val Gln 1205 1210 1215Glu
Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu Ile Gln Gln Val 1220 1225
1230Gly Asn Glu Ala Tyr Val Ile Gly Leu Ser Ser Phe His Ile Pro
1235 1240 1245Ser Ile Gly Ala Ala Cys Val Cys Phe Leu Glu Leu Leu
Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu Arg Val Asp Met Lys Val
Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr Lys Cys Arg Asn Glu Asp
Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg Glu Ser Val Ala Glu Lys
Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300 1305Lys Thr Thr Thr Glu
Glu Leu Leu Val Leu Leu Glu Glu Gly Thr 1310 1315 1320Trp Asn Ser
Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser Ser Glu 1325 1330 1335Ser
Ser Ser Gln Trp Ala Leu Val Val Gln Phe Cys Arg Leu His 1340 1345
1350Asn Met Lys Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala Lys Ala
1355 1360 1365Asn Asp Trp Leu Gln Phe Ile Ile His Ser Gln Leu His
Asn Tyr 1370 1375 1380His Pro Ala Glu Val Lys Ser Leu Ile Gln Tyr
Phe Ser Pro Val 1385 1390 1395Ile Gln Asp His Leu Arg Leu Ala Phe
Glu Asn Leu Pro Ser Val 1400 1405 1410Pro Thr Ser Lys Met Asp Ser
Asp Gln Val Cys Asn Lys Cys Pro 1415 1420 1425Gln Glu Leu Gln Gly
Ser Lys Gln Glu Met Thr Asp Leu Phe Glu 1430 1435 1440Ile Leu Leu
Gln Cys Ser Glu Glu Pro Asp Ser Trp His Trp Leu 1445 1450 1455Leu
Val Glu Ala Val Lys Gln Gln Ala Pro Ile Leu Ser Val Leu 1460 1465
1470Ala Ser Cys Leu Gln Gly Ala Ser Ala Ile Ser Cys Leu Cys Val
1475 1480 1485Trp Ile Ile Thr Ser Val Glu Asp Asn Val Ala Thr Glu
Ala Met 1490 1495 1500Gly His Ile Gln Asp Ser Thr Glu Asp His Thr
Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser Val Ile Trp Arg Thr Leu
Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys Thr Leu Ile Arg Gly Phe
Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540 1545Leu Leu Leu Val Met
Glu Met Tyr Glu Leu Cys Met Phe Phe Arg 1550 1555 1560Asn Tyr Lys
Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln Lys Ser 1565 1570 1575Leu
Glu Thr Leu Asn Thr Ala Ala Thr Lys Val His Pro Val Ile 1580 1585
1590Pro Ala Met Trp Leu Glu Asp Gln Val Cys Phe Leu Leu Lys Leu
1595 1600 1605Met Leu Gln Gln Cys Lys Thr Gln Tyr Glu Leu Gly Lys
Leu Leu 1610 1615 1620Gln Leu Phe Val Glu Arg Glu His Leu Phe Ser
Asp Gly Pro Asp 1625 1630 1635Val Lys Lys Leu Cys Ile Leu Cys Gln
Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile Ala Ile Asn His Thr Ile
Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660 1665Leu Gln His Glu Cys
Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp 1670 1675 1680Gly Gln Phe
Ala Leu Ala Arg Arg Val Ala Glu Leu Ala Glu Leu 1685 1690 1695Pro
Val Asp Asn Leu Val Ile Lys Glu Ile Thr Gln Glu Met Gln 1700 1705
1710Thr Leu Lys His Ile Glu Gln Trp Ser Leu Lys Gln Ala Arg Ile
1715 1720 1725Asp Phe Trp Lys Lys Cys His Glu Asn Phe Lys Lys Asn
Ser Ile 1730 1735 1740Ser Ser Lys Ala Ala Ser Ser Phe Phe Ser Thr
Gln Ala His Val 1745 1750 1755Ala Cys Glu His Pro Thr Gly Trp Ser
Ser Met Glu Glu Arg His 1760 1765 1770Leu Leu Leu Thr Leu Ala Gly
His Trp Leu Ala Gln Glu Asp Val 1775 1780 1785Val Pro Leu Asp Lys
Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu 1790 1795 1800Cys Arg Ile
Thr Gln His Thr Leu Gly Arg Asn Gln Glu Glu Thr 1805 1810 1815Glu
Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser Gly Glu Leu Ser 1820 1825
1830Phe Asp Ser Leu Ala Ser Glu Phe Ser Phe Ser Lys Leu Ala Ala
1835 1840 1845Leu Asn Thr Ser Lys Tyr Leu Glu Leu Asn Ser Leu Pro
Ser Lys 1850 1855 1860Glu Thr Cys Glu Asn Arg Leu Asp Trp Lys Glu
Gln Glu Ser Leu 1865 1870 1875Asn Phe Leu Ile Gly Arg Leu Leu Asp
Asp Gly Cys Val His Glu 1880 1885 1890Ala Ser Arg Val Cys Arg Tyr
Phe His Phe Tyr Asn Pro Asp Val 1895 1900 1905Ala Leu Val Leu His
Cys Arg Ala Leu Ala Ser Gly Glu Ala Ser 1910 1915 1920Met Glu Asp
Leu His Pro Glu Ile His Ala Leu Leu Gln Ser Ala 1925 1930 1935Glu
Leu Leu Glu Glu Glu Ala Pro Asp Ile Pro Leu Arg Arg Val 1940 1945
1950His Ser Thr Ser Ser Leu Asp Ser Gln Lys Phe Val Thr Val Pro
1955 1960 1965Ser Ser Asn Glu Val Val Thr Asn Leu Glu Val Leu Thr
Ser Lys 1970 1975 1980Cys Leu His Gly Lys Asn Tyr Cys Arg Gln Val
Leu Cys Leu Tyr 1985 1990 1995Asp Leu Ala Lys Glu Leu Gly Cys Ser
Tyr Thr Asp Val Ala Ala 2000 2005 2010Gln Asp Gly Glu Ala Met Leu
Arg Lys Ile Leu Ala Ser Gln Gln 2015 2020 2025Pro Asp Arg Cys Lys
Arg Ala Gln Ala Phe Ile Ser Thr Gln Gly 2030 2035 2040Leu Lys Pro
Asp Thr Val Ala Glu Leu Val Ala Glu Glu Val Thr 2045 2050 2055Arg
Glu Leu Leu Thr Ser Ser Gln Gly Thr Gly His Lys Gln Met 2060 2065
2070Phe Asn Pro Thr Glu Glu Ser Gln Thr Phe Leu Gln Leu Thr Thr
2075 2080 2085Leu Cys Gln Asp Arg Thr Leu Val Gly Met Lys Leu Leu
Asp Lys 2090 2095 2100Ile Ser Ser Val Pro His Gly Glu Leu Ser Cys
Thr Thr Glu Leu 2105 2110 2115Leu Ile Leu Ala His His Cys Phe Thr
Leu Thr Cys His Met Glu 2120 2125 2130Gly Ile Ile Arg Val Leu Gln
Ala Ala His Met Leu Thr Asp Asn 2135 2140 2145His Leu Ala Pro Ser
Glu Glu Tyr Gly Leu Val Val Arg Leu Leu 2150 2155 2160Thr Gly Ile
Gly Arg Tyr Asn Glu Met Thr Tyr Ile Phe Asp Leu 2165 2170 2175Leu
His Lys Lys His Tyr Phe Glu Val Leu Met Arg Lys Lys Leu 2180 2185
2190Asp Pro Ser Gly Thr Leu Lys Thr Ala Leu Leu Asp Tyr Ile Lys
2195 2200 2205Arg Cys Arg Pro Gly Asp Ser Glu Lys His Asn Met Ile
Ala Leu 2210 2215 2220Cys Phe Ser Met Cys Arg Glu Ile Gly Glu Asn
His Glu Ala Ala 2225 2230 2235Ala Arg Ile Gln Leu Lys Leu Ile Leu
Ser Pro Gly Arg Thr Ala 2240 2245 2250Ser Arg Met Gly Thr Ser
22551872285PRTHomo sapiens 187Met Ala Ala Glu Glu Gly Val Ala Ser
Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala Met Gly Arg
Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu Ala Met Gly
Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro Glu Ala Leu
Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu Ser Leu Thr
Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75 80Glu Gly Pro
Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser 85 90 95Thr Pro
Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr Glu 100 105
110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys Asp Ala Thr
115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln Lys Leu Ile
Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser Leu Arg Ile
Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu Phe Ile Asn
Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu Arg Asp Ala
Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro Leu Pro Ala
Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200 205Cys Arg Gly
Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile 210 215 220Phe
Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu Ala Leu225 230
235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln Glu Pro Ala Lys
Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser Gln Asp Leu Asp
Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser Ala Val Ala Leu
Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro Gly His Leu Leu
Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile Gln Gly Pro Lys
Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315 320Ser Ala Tyr Asn
Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg 325 330 335Ser Trp
Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys Asn Ser 340 345
350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln Asp Ile Leu His
355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser Thr Ser Val Gln
Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met His Gly Gln Tyr
Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys Thr Ser Asp Pro
Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser Glu Gln Glu Glu
Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr Gly Phe Thr Ala
Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440 445Thr Ile Thr
Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser 450 455 460Leu
Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln Gln Leu465 470
475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu Ile Leu Phe Gly
Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu Met Ile His Gly
Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His Leu Asn Gly Trp
Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu Glu Ala Gly Ile
Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe Phe Leu Lys Ser
Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555 560Lys Ser Ser Val
Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr 565 570 575Leu Arg
Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu Cys Ser 580 585
590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys His Phe Ser Glu
595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu Asn Asn Gln Ile
Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu Asp Glu His Leu
Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser Tyr Ile Asn Glu
Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp Lys Leu Thr Asp
Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn Val Pro Lys Val
Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680 685Glu Glu Val
Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala 690 695 700Gln
Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu Glu Glu705 710
715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp Asn Leu Lys Lys
Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu Lys Asn Met Gly
Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile Cys Phe Tyr Thr
Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val Glu Ile Leu Lys
Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys Arg Thr Ile Asp
Phe Val His Gln Val Glu Lys Leu Tyr785 790 795 800Leu Gly His Phe
Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr 805 810 815Trp Ile
Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu Asp Ser 820 825
830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys Gln Asp His Arg
835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu Thr Gln
Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys
Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg Tyr Leu Thr Ala
Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp Ile Gly Glu Phe
Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905 910Gln Gln Asn Lys Trp
Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn 915 920 925Thr Ser Cys
Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala 930 935 940Arg
Asn Gly
Val Phe Leu Ala Ser Glu Leu Glu Asp Phe Glu Cys Phe945 950 955
960Leu Leu Arg Leu Ser Arg Ile Gly Gly Val Ile Gln Asp Thr Leu Pro
965 970 975Val Gln Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe His Ser
Gln Phe 980 985 990Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His Leu
Leu Tyr Val Tyr 995 1000 1005Leu Asp Cys Tyr Lys Leu Ser Pro Glu
Asn Cys Pro Phe Leu Glu 1010 1015 1020Lys Lys Glu Leu His Glu Ala
His Pro Trp Phe Glu Phe Leu Val 1025 1030 1035Gln Cys Arg Gln Val
Ala Ser Asn Leu Thr Asp Pro Lys Leu Ile 1040 1045 1050Phe Gln Ala
Ser Leu Ala Asn Ala Gln Ile Leu Ile Pro Thr Asn 1055 1060 1065Gln
Ala Ser Val Ser Ser Met Leu Leu Glu Gly His Thr Leu Leu 1070 1075
1080Ala Leu Ala Thr Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val
1085 1090 1095Val Gln Asn Glu Glu Asn Glu Asn Cys Leu Lys Lys Val
Asp Pro 1100 1105 1110Gln Leu Leu Lys Met Ala Leu Thr Pro Tyr Pro
Lys Leu Lys Thr 1115 1120 1125Ala Leu Phe Pro Gln Cys Thr Pro Pro
Ser Val Leu Pro Ser Asp 1130 1135 1140Ile Thr Ile Tyr His Leu Ile
Gln Ser Leu Ser Pro Phe Asp Pro 1145 1150 1155Ser Arg Leu Phe Gly
Trp Gln Ser Ala Asn Thr Leu Ala Ile Gly 1160 1165 1170Asp Ala Trp
Ser His Leu Pro His Phe Ser Ser Pro Asp Leu Val 1175 1180 1185Asn
Lys Tyr Ala Ile Val Glu Arg Leu Asn Phe Ala Tyr Tyr Leu 1190 1195
1200His Asn Gly Arg Pro Ser Phe Ala Phe Gly Thr Phe Leu Val Gln
1205 1210 1215Glu Leu Ile Lys Ser Lys Thr Pro Lys Gln Leu Ile Gln
Gln Val 1220 1225 1230Gly Asn Glu Ala Tyr Val Ile Gly Leu Ser Ser
Phe His Ile Pro 1235 1240 1245Ser Ile Gly Ala Ala Cys Val Cys Phe
Leu Glu Leu Leu Gly Leu 1250 1255 1260Asp Ser Leu Lys Leu Arg Val
Asp Met Lys Val Ala Asn Ile Ile 1265 1270 1275Leu Ser Tyr Lys Cys
Arg Asn Glu Asp Ala Gln Tyr Ser Phe Ile 1280 1285 1290Arg Glu Ser
Val Ala Glu Lys Leu Ser Lys Leu Ala Asp Gly Glu 1295 1300 1305Lys
Thr Thr Thr Glu Glu Leu Leu Val Leu Leu Glu Glu Gly Thr 1310 1315
1320Trp Asn Ser Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser Ser Glu
1325 1330 1335Ser Ser Ser Gln Trp Ala Leu Val Val Gln Phe Cys Arg
Leu His 1340 1345 1350Asn Met Lys Leu Ser Ile Ser Tyr Leu Arg Glu
Cys Ala Lys Ala 1355 1360 1365Asn Asp Trp Leu Gln Phe Ile Ile His
Ser Gln Leu His Asn Tyr 1370 1375 1380His Pro Ala Glu Val Lys Ser
Leu Ile Gln Tyr Phe Ser Pro Val 1385 1390 1395Ile Gln Asp His Leu
Arg Leu Ala Phe Glu Asn Leu Pro Ser Val 1400 1405 1410Pro Thr Ser
Lys Met Asp Ser Asp Gln Val Cys Asn Lys Cys Pro 1415 1420 1425Gln
Glu Leu Gln Gly Ser Lys Gln Glu Met Thr Asp Leu Phe Glu 1430 1435
1440Ile Leu Leu Gln Cys Ser Glu Glu Pro Asp Ser Trp His Trp Leu
1445 1450 1455Leu Val Glu Ala Val Lys Gln Gln Ala Pro Ile Leu Ser
Val Leu 1460 1465 1470Ala Ser Cys Leu Gln Gly Ala Ser Ala Ile Ser
Cys Leu Cys Val 1475 1480 1485Trp Ile Ile Thr Ser Val Glu Asp Asn
Val Ala Thr Glu Ala Met 1490 1495 1500Gly His Ile Gln Asp Ser Thr
Glu Asp His Thr Trp Asn Leu Glu 1505 1510 1515Asp Leu Ser Val Ile
Trp Arg Thr Leu Leu Thr Arg Gln Lys Ser 1520 1525 1530Lys Thr Leu
Ile Arg Gly Phe Gln Leu Phe Phe Lys Asp Ser Pro 1535 1540 1545Leu
Leu Leu Val Met Glu Met Tyr Glu Leu Cys Met Phe Phe Arg 1550 1555
1560Asn Tyr Lys Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln Lys Ser
1565 1570 1575Leu Glu Thr Leu Asn Thr Ala Ala Thr Lys Val His Pro
Val Ile 1580 1585 1590Pro Ala Met Trp Leu Glu Asp Gln Val Cys Phe
Leu Leu Lys Leu 1595 1600 1605Met Leu Gln Gln Cys Lys Thr Gln Tyr
Glu Leu Gly Lys Leu Leu 1610 1615 1620Gln Leu Phe Val Glu Arg Glu
His Leu Phe Ser Asp Gly Pro Asp 1625 1630 1635Val Lys Lys Leu Cys
Ile Leu Cys Gln Ile Leu Lys Asp Thr Ser 1640 1645 1650Ile Ala Ile
Asn His Thr Ile Ile Thr Ser Tyr Ser Ile Glu Asn 1655 1660 1665Leu
Gln His Glu Cys Arg Ser Ile Leu Glu Arg Leu Gln Thr Asp 1670 1675
1680Gly Gln Phe Ala Leu Ala Arg Arg Val Ala Glu Leu Ala Glu Leu
1685 1690 1695Pro Val Asp Asn Leu Val Ile Lys Glu Ile Thr Gln Glu
Met Gln 1700 1705 1710Thr Leu Lys His Ile Glu Gln Trp Ser Leu Lys
Gln Ala Arg Ile 1715 1720 1725Asp Phe Trp Lys Lys Cys His Glu Asn
Phe Lys Lys Asn Ser Ile 1730 1735 1740Ser Ser Lys Ala Ala Ser Ser
Phe Phe Ser Thr Gln Ala His Val 1745 1750 1755Ala Cys Glu His Pro
Thr Gly Trp Ser Ser Met Glu Glu Arg His 1760 1765 1770Leu Leu Leu
Thr Leu Ala Gly His Trp Leu Ala Gln Glu Asp Val 1775 1780 1785Val
Pro Leu Asp Lys Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu 1790 1795
1800Cys Arg Ile Thr Gln His Thr Leu Gly Arg Asn Gln Glu Glu Thr
1805 1810 1815Glu Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser Gly Glu
Leu Ser 1820 1825 1830Phe Asp Ser Leu Ala Ser Glu Phe Ser Phe Ser
Lys Leu Ala Ala 1835 1840 1845Leu Asn Thr Ser Lys Tyr Leu Glu Leu
Asn Ser Leu Pro Ser Lys 1850 1855 1860Glu Thr Cys Glu Asn Arg Leu
Asp Trp Lys Glu Gln Glu Ser Leu 1865 1870 1875Asn Phe Leu Ile Gly
Arg Leu Leu Asp Asp Gly Cys Val His Glu 1880 1885 1890Ala Ser Arg
Val Cys Arg Tyr Phe His Phe Tyr Asn Pro Asp Val 1895 1900 1905Ala
Leu Val Leu His Cys Arg Ala Leu Ala Ser Gly Glu Ala Ser 1910 1915
1920Met Glu Asp Leu His Pro Glu Ile His Ala Leu Leu Gln Ser Ala
1925 1930 1935Glu Leu Leu Glu Glu Glu Ala Pro Asp Ile Pro Leu Arg
Arg Val 1940 1945 1950His Ser Thr Ser Ser Leu Asp Ser Gln Lys Phe
Val Thr Val Pro 1955 1960 1965Ser Ser Asn Glu Val Val Thr Asn Leu
Glu Val Leu Thr Ser Lys 1970 1975 1980Cys Leu His Gly Lys Asn Tyr
Cys Arg Gln Val Leu Cys Leu Tyr 1985 1990 1995Asp Leu Ala Lys Glu
Leu Gly Cys Ser Tyr Thr Asp Val Ala Ala 2000 2005 2010Gln Asp Gly
Glu Ala Met Leu Arg Lys Ile Leu Ala Ser Gln Gln 2015 2020 2025Pro
Asp Arg Cys Lys Arg Ala Gln Ala Phe Ile Ser Thr Gln Gly 2030 2035
2040Leu Lys Pro Asp Thr Val Ala Glu Leu Val Ala Glu Glu Val Thr
2045 2050 2055Arg Glu Leu Leu Thr Ser Ser Gln Gly Thr Gly His Lys
Gln Met 2060 2065 2070Phe Asn Pro Thr Glu Glu Ser Gln Thr Phe Leu
Gln Leu Thr Thr 2075 2080 2085Leu Cys Gln Asp Arg Thr Leu Val Gly
Met Lys Leu Leu Asp Lys 2090 2095 2100Ile Ser Ser Val Pro His Gly
Glu Leu Ser Cys Thr Thr Glu Leu 2105 2110 2115Leu Ile Leu Ala His
His Cys Phe Thr Leu Thr Cys His Met Glu 2120 2125 2130Gly Ile Ile
Arg Val Leu Gln Ala Ala His Met Leu Thr Asp Asn 2135 2140 2145His
Leu Ala Pro Ser Glu Glu Tyr Gly Leu Val Val Arg Leu Leu 2150 2155
2160Thr Gly Ile Gly Arg Tyr Asn Glu Met Thr Tyr Ile Phe Asp Leu
2165 2170 2175Leu His Lys Lys His Tyr Phe Glu Val Leu Met Arg Lys
Lys Leu 2180 2185 2190Asp Pro Ser Gly Thr Leu Lys Thr Ala Leu Leu
Asp Tyr Ile Lys 2195 2200 2205Arg Cys Arg Pro Gly Asp Ser Glu Lys
His Asn Met Ile Ala Leu 2210 2215 2220Cys Phe Ser Met Cys Arg Glu
Ile Gly Glu Asn His Glu Ala Ala 2225 2230 2235Ala Arg Ile Gln Leu
Lys Leu Ile Glu Ser Gln Pro Trp Glu Asp 2240 2245 2250Ser Leu Lys
Asp Gly His Gln Leu Lys Gln Leu Leu Leu Lys Ala 2255 2260 2265Leu
Thr Leu Met Leu Asp Ala Ala Glu Ser Tyr Ala Lys Asp Ser 2270 2275
2280Cys Val 2285188949PRTHomo sapiens 188Met Ala Ala Glu Glu Gly
Val Ala Ser Ala Ala Ser Ala Gly Gly Ser1 5 10 15Trp Gly Thr Ala Ala
Met Gly Arg Val Leu Pro Met Leu Leu Val Pro 20 25 30Val Pro Ala Glu
Ala Met Gly Gln Leu Gly Ser Arg Ala Gln Leu Arg 35 40 45Thr Gln Pro
Glu Ala Leu Gly Ser Leu Thr Ala Ala Gly Ser Leu Gln 50 55 60Val Leu
Ser Leu Thr Pro Gly Ser Arg Gly Gly Gly Arg Cys Cys Leu65 70 75
80Glu Gly Pro Phe Trp His Phe Leu Trp Glu Asp Ser Arg Asn Ser Ser
85 90 95Thr Pro Thr Glu Lys Pro Lys Leu Leu Ala Leu Gly Glu Asn Tyr
Glu 100 105 110Leu Leu Ile Tyr Glu Phe Asn Leu Lys Asp Gly Arg Cys
Asp Ala Thr 115 120 125Ile Leu Tyr Ser Cys Ser Arg Glu Ala Leu Gln
Lys Leu Ile Asp Asp 130 135 140Gln Asp Ile Ser Ile Ser Leu Leu Ser
Leu Arg Ile Leu Ser Phe His145 150 155 160Asn Asn Thr Ser Leu Leu
Phe Ile Asn Lys Cys Val Ile Leu His Ile 165 170 175Ile Phe Pro Glu
Arg Asp Ala Ala Ile Arg Val Leu Asn Cys Phe Thr 180 185 190Leu Pro
Leu Pro Ala Gln Ala Val Asp Met Ile Ile Asp Thr Gln Leu 195 200
205Cys Arg Gly Ile Leu Phe Val Leu Ser Ser Leu Gly Trp Ile Tyr Ile
210 215 220Phe Asp Val Val Asp Gly Thr Tyr Val Ala His Val Asp Leu
Ala Leu225 230 235 240His Lys Glu Asp Met Cys Asn Glu Gln Gln Gln
Glu Pro Ala Lys Ile 245 250 255Ser Ser Phe Thr Ser Leu Lys Val Ser
Gln Asp Leu Asp Val Ala Val 260 265 270Ile Val Ser Ser Ser Asn Ser
Ala Val Ala Leu Asn Leu Asn Leu Tyr 275 280 285Phe Arg Gln His Pro
Gly His Leu Leu Cys Glu Arg Ile Leu Glu Asp 290 295 300Leu Pro Ile
Gln Gly Pro Lys Gly Val Asp Glu Asp Asp Pro Val Asn305 310 315
320Ser Ala Tyr Asn Met Lys Leu Ala Lys Phe Ser Phe Gln Ile Asp Arg
325 330 335Ser Trp Lys Ala Gln Leu Ser Ser Leu Asn Glu Thr Ile Lys
Asn Ser 340 345 350Lys Leu Glu Val Ser Cys Cys Ala Pro Trp Phe Gln
Asp Ile Leu His 355 360 365Leu Glu Ser Pro Glu Ser Gly Asn His Ser
Thr Ser Val Gln Ser Trp 370 375 380Ala Phe Ile Pro Gln Asp Ile Met
His Gly Gln Tyr Asn Val Leu Gln385 390 395 400Lys Asp His Ala Lys
Thr Ser Asp Pro Gly Arg Ser Trp Lys Ile Met 405 410 415His Ile Ser
Glu Gln Glu Glu Pro Ile Glu Leu Lys Cys Val Ser Val 420 425 430Thr
Gly Phe Thr Ala Leu Phe Thr Trp Glu Val Glu Arg Met Gly Tyr 435 440
445Thr Ile Thr Leu Trp Asp Leu Glu Thr Gln Gly Met Gln Cys Ser Ser
450 455 460Leu Gly Thr Lys Cys Ile Pro Val Asp Ser Ser Gly Asp Gln
Gln Leu465 470 475 480Cys Phe Val Leu Thr Glu Asn Gly Leu Ser Leu
Ile Leu Phe Gly Leu 485 490 495Thr Gln Glu Glu Phe Leu Asn Arg Leu
Met Ile His Gly Ser Ala Ser 500 505 510Thr Val Asp Thr Leu Cys His
Leu Asn Gly Trp Gly Arg Cys Ser Ile 515 520 525Pro Ile His Ala Leu
Glu Ala Gly Ile Glu Asn Arg Gln Leu Asp Thr 530 535 540Val Asn Phe
Phe Leu Lys Ser Lys Glu Asn Leu Phe Asn Pro Ser Ser545 550 555
560Lys Ser Ser Val Ser Asp Gln Phe Asp His Leu Ser Ser His Leu Tyr
565 570 575Leu Arg Asn Val Glu Glu Leu Ile Pro Ala Leu Asp Leu Leu
Cys Ser 580 585 590Ala Ile Arg Glu Ser Tyr Ser Glu Pro Gln Ser Lys
His Phe Ser Glu 595 600 605Gln Leu Leu Asn Leu Thr Leu Ser Phe Leu
Asn Asn Gln Ile Lys Glu 610 615 620Leu Phe Ile His Thr Glu Glu Leu
Asp Glu His Leu Gln Lys Gly Val625 630 635 640Asn Ile Leu Thr Ser
Tyr Ile Asn Glu Leu Arg Thr Phe Met Ile Lys 645 650 655Phe Pro Trp
Lys Leu Thr Asp Ala Ile Asp Glu Tyr Asp Val His Glu 660 665 670Asn
Val Pro Lys Val Lys Glu Ser Asn Ile Trp Lys Lys Leu Ser Phe 675 680
685Glu Glu Val Ile Ala Ser Ala Ile Leu Asn Asn Lys Ile Pro Glu Ala
690 695 700Gln Thr Phe Phe Arg Ile Asp Ser His Ser Ala Gln Lys Leu
Glu Glu705 710 715 720Leu Ile Gly Ile Gly Leu Asn Leu Val Phe Asp
Asn Leu Lys Lys Asn 725 730 735Asn Ile Lys Glu Ala Ser Glu Leu Leu
Lys Asn Met Gly Phe Asp Val 740 745 750Lys Gly Gln Leu Leu Lys Ile
Cys Phe Tyr Thr Thr Asn Lys Asn Ile 755 760 765Arg Asp Phe Leu Val
Glu Ile Leu Lys Glu Lys Asn Tyr Phe Ser Glu 770 775 780Lys Glu Lys
Arg Thr Ile Asp Phe Val His Gln Val Glu Lys Leu Tyr785 790 795
800Leu Gly His Phe Gln Glu Asn Met Gln Ile Gln Ser Phe Pro Arg Tyr
805 810 815Trp Ile Lys Glu Gln Asp Phe Phe Lys His Lys Ser Val Leu
Asp Ser 820 825 830Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys
Gln Asp His Arg 835 840 845Ile Val Leu Asn Trp Ala Leu Trp Trp Asp
Gln Leu Thr Gln Glu Ser 850 855 860Ile Leu Leu Pro Arg Ile Ser Pro
Glu Glu Tyr Lys Ser Tyr Ser Pro865 870 875 880Glu Ala Leu Trp Arg
Tyr Leu Thr Ala Arg His Asp Trp Leu Asn Ile 885 890 895Ile Leu Trp
Ile Gly Glu Phe Gln Thr Gln His Ser Tyr Ala Ser Leu 900 905 910Gln
Gln Asn Lys Trp Pro Leu Leu Thr Val Asp Val Ile Asn Gln Asn 915 920
925Thr Ser Cys Asn Asn Tyr Met Arg Asn Glu Ile Leu Asp Lys Leu Ala
930 935 940Gly Tyr Tyr Asn Cys945
uspto.report is an independent third-party trademark research tool that is not affiliated, endorsed, or sponsored by the United States Patent and Trademark Office (USPTO) or any other governmental organization. The information provided by uspto.report is based on publicly available data at the time of writing and is intended for informational purposes only.
While we strive to provide accurate and up-to-date information, we do not guarantee the accuracy, completeness, reliability, or suitability of the information displayed on this site. The use of this site is at your own risk. Any reliance you place on such information is therefore strictly at your own risk.
All official trademark data, including owner information, should be verified by visiting the official USPTO website at www.uspto.gov. This site is not intended to replace professional legal advice and should not be used as a substitute for consulting with a legal professional who is knowledgeable about trademark law.