U.S. patent application number 12/861911 was filed with the patent office on 2011-05-05 for taste potentiator compositions and edible confectionery and chewing gum products containing same.
Invention is credited to Navroz Boghani, Petros Gebreselassie, Carole Ann Hargreaves.
Application Number | 20110104329 12/861911 |
Document ID | / |
Family ID | 36950866 |
Filed Date | 2011-05-05 |
United States Patent
Application |
20110104329 |
Kind Code |
A1 |
Boghani; Navroz ; et
al. |
May 5, 2011 |
TASTE POTENTIATOR COMPOSITIONS AND EDIBLE CONFECTIONERY AND CHEWING
GUM PRODUCTS CONTAINING SAME
Abstract
The present invention relates to compositions and edible orally
delivered products, such as confectioneries and chewing gum, which
include taste potentiators to enhance the perception of active
substances contained therein. More specifically, some embodiments
provide potentiator compositions, which include at least one active
substance and at least one taste potentiator. The active substance
and/or taste potentiator may be encapsulated in some embodiments to
modify the release rate of the composition upon consumption.
Inventors: |
Boghani; Navroz; (Flanders,
NJ) ; Gebreselassie; Petros; (Piscataway, NJ)
; Hargreaves; Carole Ann; (Caversham, GB) |
Family ID: |
36950866 |
Appl. No.: |
12/861911 |
Filed: |
August 24, 2010 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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11439830 |
May 23, 2006 |
7851000 |
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12861911 |
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60683634 |
May 23, 2005 |
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60760437 |
Jan 20, 2006 |
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60789667 |
Apr 6, 2006 |
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Current U.S.
Class: |
426/3 ;
426/548 |
Current CPC
Class: |
A23V 2002/00 20130101;
A23G 9/32 20130101; A23L 27/204 20160801; A23L 27/30 20160801; A23G
4/20 20130101; A23P 10/30 20160801; A23L 27/82 20160801; A23G 4/205
20130101; A23L 27/20 20160801; A23G 4/18 20130101; A23G 4/06
20130101; A23L 2/60 20130101; A23L 27/88 20160801; A23V 2002/00
20130101; A23V 2002/00 20130101; A23V 2250/24 20130101; A23V
2200/16 20130101; A23V 2250/24 20130101; A23V 2250/606 20130101;
A23V 2250/02 20130101; A23V 2250/02 20130101; A23V 2250/628
20130101; A23V 2200/16 20130101 |
Class at
Publication: |
426/3 ;
426/548 |
International
Class: |
A23G 4/06 20060101
A23G004/06; A23G 3/36 20060101 A23G003/36 |
Claims
1. A chewing gum composition, comprising: a gum base; and an
encapsulated sweetener potentiator; wherein the sweetener
potentiator is selected from the group consisting of 3-aminobenzoic
acid, 4-aminobenzoic acid, and combinations thereof; and an
unencapsulated sweetener.
2. The chewing gum composition of claim 1, wherein the sweetener
potentiator is 3-aminobenzoic acid.
3. The chewing gum composition of claim 1, wherein the sweetener
potentiator is 4-aminobenzoic acid.
4. The chewing gum composition of claim 1, wherein the sweetener
potentiator is a combination of 3-aminobenzoic acid and
4-aminobenzoic acid.
5. The chewing gum composition of claim 1, wherein the
unencapsulated sweetener comprises a bulk sweetener.
6. The chewing gum composition of claim 1, wherein the
unencapsulated sweetener is selected from the group consisting of
sucrose, dextrose, maltose, dextrin, xylose, ribose, glucose,
lactose, mannose, galactose, fructose, invert sugar,
fructooligosaccharide syrups, partially hydrolyzed starch, corn
syrup solids, isomaltulose, and mixtures thereof.
7. The chewing gum composition of claim 1, wherein the
unencapsulated sweetener is selected from the group consisting of
sorbitol, xylitol, erythritol, mannitol, maltitol, hydrogenated
starch hydrolysate, and mixtures thereof.
8. The chewing gum composition of claim 1, wherein the
unencapsulated sweetener is selected from the group consisting of
dihydrochalcones, monellin, stevia, steviosides, rebaudioside A,
glycyrrhizin, dihydroflavenol, saccharin, sodium saccharin, calcium
saccharin, cyclamate salts, the sodium salt of
3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, the
ammonium salt of
3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, the
ammonium salt of
3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, the
potassium salt of
3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide,
L-aspartyl-L-phenylalanine methyl ester,
L-alpha-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamide
hydrate, L-aspartyl-L-phenylglycine methyl ester,
L-aspartyl-L-2,5-dihydrophenylglycine methyl ester,
L-aspartyl-2,5-dihydro-L-phenylalanine,
L-aspartyl-L-(1-cyclohexen)-alanine, chlorodeoxysugar derivatives,
thaumatococcus danielli, talin, monatin, and lo han guo.
9. The chewing gum composition of claim 1, wherein the
unencapsulated sweetener is selected from the group consisting of
Lo han guo, stevia, monatin, and combinations thereof.
10. The chewing gum composition of claim 1, wherein the
encapsulated sweetener potentiator comprises an encapsulant
selected from the group consisting of polyvinyl acetate,
polyethylene, crosslinked polyvinyl pyrrolidone,
polymethylmethacrylate, polylacticacid, polyhydroxyalkanoates,
ethylcellulose, polyvinyl acetatephthalate,
poly(methacrylicacid-co-methylmethacrylate), and combinations
thereof.
11. The chewing gum composition of claim 1, wherein the
encapsulated sweetener potentiator comprises an encapsulant
comprising polyvinyl acetate.
12. The chewing gum composition of claim 1, comprising about 0.01%
to about 10% by weight of the encapsulated sweetener potentiator,
based on the weight of the chewing gum composition.
13. A confectionery composition, comprising: an encapsulated
sweetener potentiator; wherein the sweetener potentiator is
selected from the group consisting of 3-aminobenzoic acid,
4-aminobenzoic acid, and combinations thereof; and an
unencapsulated sweetener.
14. The confectionery composition of claim 13, wherein the
sweetener potentiator is 3-aminobenzoic acid.
15. The confectionery composition of claim 13, wherein the
sweetener potentiator is 4-aminobenzoic acid.
16. The confectionery composition of claim 13, wherein the
sweetener potentiator is a combination of 3-aminobenzoic acid and
4-aminobenzoic acid.
17. The confectionery composition of claim 13, wherein the
unencapsulated sweetener comprises a bulk sweetener.
18. The confectionery composition of claim 13, wherein the
unencapsulated sweetener is selected from the group consisting of
sucrose, dextrose, maltose, dextrin, xylose, ribose, glucose,
lactose, mannose, galactose, fructose, invert sugar,
fructooligosaccharide syrups, partially hydrolyzed starch, corn
syrup solids, isomaltulose, and mixtures thereof.
19. The confectionery composition of claim 13, wherein the
unencapsulated sweetener is selected from the group consisting of
sorbitol, xylitol, erythritol, mannitol, maltitol, hydrogenated
starch hydrolysate, and mixtures thereof.
20. The confectionery composition of claim 13, wherein the
unencapsulated sweetener is selected from the group consisting of
dihydrochalcones, monellin, stevia, steviosides, rebaudioside A,
glycyrrhizin, dihydroflavenol, saccharin, sodium saccharin, calcium
saccharin, cyclamate salts, the sodium salt of
3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, the
ammonium salt of
3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, the
ammonium salt of
3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, the
potassium salt of
3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide,
L-aspartyl-L-phenylalanine methyl ester,
L-alpha-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamide
hydrate, L-aspartyl-L-phenylglycine methyl ester,
L-aspartyl-L-2,5-dihydrophenylglycine methyl ester,
L-aspartyl-2,5-dihydro-L-phenylalanine,
L-aspartyl-L-(1-cyclohexen)-alanine, chlorodeoxysugar derivatives,
thaumatococcus danielli, talin, monatin, and lo han guo.
21. The confectionery composition of claim 1, wherein the
encapsulated sweetener potentiator comprises an encapsulant
comprising polyvinyl acetate.
22. The confectionery composition of claim 13, wherein the
unencapsulated sweetener is selected from the group consisting of
Lo han guo, stevia, monatin, and combinations thereof.
23. The confectionery composition of claim 13, wherein the
encapsulated sweetener potentiator comprises an encapsulant
selected from the group consisting of polyvinyl acetate,
polyethylene, crosslinked polyvinyl pyrrolidone,
polymethylmethacrylate, polylacticacid, polyhydroxyalkanoates,
ethylcellulose, polyvinyl acetatephthalate,
poly(methacrylicacid-co-methylmethacrylate), and combinations
thereof.
24. The confectionery composition of claim 13, comprising about
0.01% to about 10% by weight of the encapsulated sweetener
potentiator, based on the weight of the confectionery composition.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation of U.S. patent
application Ser. No. 11/439,830, filed May 23, 2006, which claims
the benefit of U.S. Provisional Application No. 60/683,634, filed
May 23, 2005, U.S. Provisional Application No. 60/760,437, filed
Jan. 20, 2006 and U.S. Provisional Application No. 60/789,667,
filed Apr. 6, 2006, the contents of which are incorporated herein
by reference.
FIELD
[0002] The present invention includes oral compositions that
provide an enhanced perception of an active substance contained
therein. In particular, the compositions may include an active
substance, such as a flavor, and a taste potentiator. The taste
potentiator may increase the perception of the active substance
upon consumption. The compositions may be incorporated into various
types of edible orally delivered products, such as confectionery or
chewing gum products.
BACKGROUND
[0003] There are five primary categories of taste that are sensed
by humans: sour, salty, sweet, bitter and umami (savory or the
taste of glutamate). The taste of a substance is sensed by taste
receptor cells located in taste buds primarily on the surface of
the tongue and palate in the oral cavity. Each of the primary taste
qualities is sensed by a specific mechanism. It is believed that
sour and salty tastes are detected by the passage of ions, hydrogen
and sodium respectively, through the ion channels in taste bud
cells. This triggers a nerve impulse that is sensed in the brain as
sour or salty. In contrast, it is believed that sweet, bitter and
umami tastes are perceived by physical binding to receptors. In
general, sweet, bitter and umami sensing taste cells have G-protein
coupled receptors (GPCRs) on their surface. These receptors are
activated when they bind to tastants, which initiates a series of
signaling events that trigger a nerve impulse that is sensed in the
brain as sweet, bitter or savory.
[0004] Over the past several years, there have been a number of
advances in research on taste perception. New taste receptor
proteins have been identified in mammals, particularly two families
of G-protein coupled receptors (T2R5 and T1R5), which are believed
to be involved in taste perception. Such receptors are discussed in
more detail in International Publication Nos. WO 02/064631 and WO
03/001876. These publications disclose that co-expression of
certain T1R receptors results in savory or sweet taste receptors
that respond to savory or sweet taste stimuli, respectively.
[0005] Recent advances in the understanding of taste perception
have created interest in identifying new compounds for stimulating
these taste receptors. In particular, research efforts also have
been directed to methods of identifying compounds that may enhance
the primary taste perceptions, such as sweet or savory perceptions.
The development of substances that provide flavor enhancement is of
particular interest, and such substances are generally referred to
as taste or flavor enhancers, or potentiators. These substances
have been thought to contribute taste, aroma and feeling factors,
as well as potentiate and suppress other flavors. The activity of
taste or flavor enhancers is often referred to as synergistic
because they enhance or increase the perception of another
substance.
[0006] One category of taste potentiators of particular interest
are compounds that enhance sweetness. Although naturally occurring
carbohydrate sweeteners, such as sucrose, are the most widely used
sweeteners, they suffer from the disadvantages of high cost and
high caloric content. Artificial sweeteners have been designed that
overcome these problems but they are sometimes rejected by the
consumer for not having a sufficiently "sucrose-like" taste.
Artificial sweeteners have different sweetness profiles from that
of sucrose and often suffer from side effects such as delays in the
onset of sweetness perception and/or unpleasant aftertastes.
[0007] Compounds are known which, when combined with a sweetener,
modify the taste of the sweetener. Such compounds are usually
referred to as sweetness modifiers or potentiators. They may act to
enhance or inhibit the perception of the sweetness of the sweetener
or may affect the sweetness profile in some way. For example,
Canadian Patent No. 1208966 discloses a broad range of aromatic
compounds which are claimed as sweetness modifiers.
[0008] European Patent No. 0132444 and U.S. Pat. No. 4,627,987
describe 3-hydroxybenzoic acid (3-HB) as a sweetness potentiator
and exemplify its use with sucrose, aspartame and saccharin to
enhance sweetness when employed at pH 2.0 to 5.5.
[0009] 2,4-Dihydroxybenzoic acid (2,4-DHB) also is described as a
sweetness potentiator, but the literature is ambiguous as to its
effects. In U.S. Pat. No. 5,232,735 it is listed as a
"substantially tasteless sweetness inhibitor" whereas in Canadian
Patent No. 1208966 the addition of 0.2% 2,4-DHB to a 5% sucrose
solution is said to have resulted in an increase in sweetness.
International Publication No. WO99/15032 describes the use of
2,4-DHB with aspartame to increase sweetness synergistically and
provide a more "sucrose-like" taste and mouthfeel. The combination
is considered peculiar, in that the same effect is not observed
when 2,4-DHB is combined with the alternative artificial
sweeteners, alitame, Ace-K (acesulfame potassium), saccharin or
even a mixture of aspartame and Ace-K. U.S. Pat. No. 6,461,658
claims that 2,4-DHB improves the sweetness delivery profile of the
artificial sweetener sucralose by significantly reducing the length
of time during which sucralose sweetness is perceived. The same
effect is not observed for aspartame even though this might be
expected in light of International Publication No. WO99/15032.
FIGS. 1 and 2 and Tables 1 and 2 of U.S. Pat. No. 6,461,658 seem to
indicate that 2,4-DHB has a slightly inhibitory effect on the
sweetness intensity of both sucralose and aspartame although this
is not discussed in the text.
[0010] International Publication No. WO00/69282 describes the
modification of the taste and physicochemical properties of the
sweetener neotame by the addition of at least one taste modifying
hydrophobic acid additive. The taste modifying hydrophobic acid
additive is limited only in that it must positively affect at least
one taste characteristic imparted by neotame. These characteristics
appear to be related to the sweetness profile, specifically the
onset and linger period, but the examples do not describe how the
characteristics have been affected. 3-HB and 2,4-DHB are listed
among a very large number of such additives.
[0011] Additionally, there have been a number of recent
developments related to methods of identifying substances that
function as taste potentiators. Various assays have been developed
to identify target compounds that modulate the activity of taste
receptors, and thus, may become successful taste potentiators. For
example, International Publication Nos. WO 02/064631 and WO
03/001876, referred to above, disclose assays and high-throughput
screens that measure certain T1R receptor activity in the presence
of target compounds.
[0012] U.S. Pat. No. 6,955,887 to Adler et al. discloses methods
for identifying taste potentiators using newly identified mammalian
taste-cell-specific G-protein coupled receptors. More specifically,
U.S. Pat. No. 6,955,887 teaches methods for screening target
compounds that may be used to modulate the sweet taste
perception.
[0013] Various other methods for screening compounds that may be
used as taste potentiators are disclosed in the U.S. Patent
Publication Nos. 2005/0287517A1, 2005/0084932A1, 2005/0069944A1,
2005/0032158A1, 2004/0229239A1, 2004/0209286A1, 2004/0191805A1,
2004/0185469A1, 2004/0175793A1, 2004/0175792A1, 2004/0171042A1,
2004/0132075A1, 2004/0072254A1, 2003/0232407A1, 2003/0170608A1 and
2003/0054448A1.
[0014] Despite progress in developing methods for identifying new
taste potentiators, there is still a need for oral, particularly
confectionery, compositions that include such taste potentiators.
Further, there is a need for compositions that control the release
rate of the taste potentiator from the composition. In particular,
there is a need for chewing gums and other related confectioneries
that control the release profile of taste potentiators, as desired,
to manage the release profile of the chewing gum or confectionery
product. Moreover, it would be desirable to develop a sweetener
potentiator composition that allows the quantity of natural or
artificial sweetener in an orally delivered product to be reduced,
thereby reducing the cost of production and the calorie content of
the orally delivered product, but which avoids adverse effects on
flavor.
SUMMARY
[0015] In some embodiments there is a controlled-release
composition including at least one active substance and at least
one encapsulated taste potentiator.
[0016] In some embodiments there is a controlled-release
composition including an encapsulated mixture of at least one taste
potentiator and at least one active substance.
[0017] In some embodiments there is a controlled-release
composition including at least one encapsulated active substance
and at least one taste potentiator.
[0018] In some embodiments there is a controlled-release
composition including at least one active substance and at least
one taste potentiator.
[0019] In some embodiments, a controlled-release composition
includes at least one encapsulated active substance and at least
one encapsulated taste potentiator.
[0020] In some embodiments there is a controlled-release
composition including at least one intense sweetener and at least
one encapsulated sweetener potentiator.
[0021] In some embodiments there is a composition including at
least one active substance and at least one encapsulated taste
potentiator.
[0022] In some embodiments there is a composition including an
encapsulated mixture of at least one taste potentiator and at least
one active substance.
[0023] In some embodiments there is a composition including at
least one encapsulated active substance and at least one taste
potentiator.
[0024] In some embodiments there is a composition including at
least one active substance and at least one taste potentiator.
[0025] In some embodiments there is a composition including at
least one encapsulated active substance and at least one
encapsulated taste potentiator.
[0026] In some embodiments there is a composition including at
least one intense sweetener and at least one encapsulated sweetener
potentiator.
[0027] In some embodiments there is a composition that modulates
the activity of taste receptor cells in a mammal, which includes at
least one active substance and at least one encapsulated taste
potentiator, wherein the at least one encapsulated taste
potentiator acts in conjunction with the at least one active
substance to modulate the activity of the taste receptor cells upon
consumption of the composition, thereby enhancing the perception of
the at least one active substance.
[0028] Some embodiments provide a sweetener potentiator
composition, which includes a first amount of 3-hydroxybenzoic acid
and a second amount of 2,4-dihydroxybenzoic acid, wherein the first
amount is equal to the second amount.
[0029] In some embodiments, there is a sweetener potentiator
composition, including a first amount of 3-hydroxybenzoic acid and
a second amount of 2,4-dihydroxybenzoic acid, wherein the sweetener
potentiator composition contains sufficient amounts of the first
amount of 3-hydroxybenzoic acid and the second amount of
2,4-dihydroxybenzoic acid to create a sucrose equivalent value of
at least seven %.
[0030] In some embodiments, there is a sweetener potentiator
composition, which includes a first amount of 3-hydroxybenzoic acid
and a second amount of 2,4-dihydroxybenzoic acid, wherein the
sweetener potentiator composition contains sufficient amounts of
the first amount of 3-hydroxybenzoic acid and the second amount of
2,4-dihydroxybenzoic acid to create a sucrose equivalent value of
at least eight %.
[0031] Some embodiments provide a sweetener potentiator
composition, which includes a first amount of 3-hydroxybenzoic acid
and a second amount of 2,4-dihydroxybenzoic acid, wherein the
sweetener potentiator composition contains at least 200 ppm of the
first amount of 3-hydroxybenzoic acid and at least 200 ppm of the
second amount of 2,4-dihydroxybenzoic acid.
[0032] Some embodiments provide a sweetener potentiator
composition, including a first amount of 3-hydroxybenzoic acid and
a second amount of 2,4-dihydroxybenzoic acid, wherein the sweetener
potentiator composition contains at least 400 ppm of the first
amount of 3-hydroxybenzoic acid and at least 400 ppm of the second
amount of 2,4-dihydroxybenzoic acid.
[0033] Some embodiments provide a sweetener potentiator
composition, including a first amount of 3-hydroxybenzoic acid and
a second amount of 2,4-dihydroxybenzoic acid, wherein the sweetener
potentiator composition contains at least 500 ppm of the first
amount of 3-hydroxybenzoic acid and at least 500 ppm of the second
amount of 2,4-dihydroxybenzoic acid.
[0034] Some embodiments provide a sweetener potentiator
composition, which includes a first amount of 3-hydroxybenzoic acid
and a second amount of 2,4-dihydroxybenzoic acid, wherein the
sweetener potentiator composition contains a ratio by weight of the
first amount of 3-hydroxybenzoic acid to the second amount of
2,4-dihydroxybenzoic acid between 1:9 and 9:1.
[0035] In some embodiments, there is a sweetener potentiator
composition, which includes a first amount of 3-hydroxybenzoic acid
and a second amount of 2,4-dihydroxybenzoic acid, wherein the
sweetener potentiator composition is in a form of a blended
powder.
[0036] Some embodiments provide a sweetener potentiator
composition, including a first amount of 3-hydroxybenzoic acid, a
second amount of 2,4-dihydroxybenzoic acid and a third amount of
3,4-dihydroxybenzoic acid.
[0037] In some embodiments there is a chewing gum composition,
which includes:
[0038] (a) a gum base; and
[0039] (b) a composition including: [0040] (i) at least one active
substance; and [0041] (ii) at least one encapsulated taste
potentiator.
[0042] In some embodiments there is a chewing gum composition
including:
[0043] (a) a gum base;
[0044] (b) at least one bulk sweetener;
[0045] (c) a composition including: [0046] (i) at least one active
substance; and [0047] (ii) at least one encapsulated taste
potentiator; and
[0048] (d) optionally at least one flavor.
[0049] In some embodiments there is a chewing gum composition
including:
[0050] (a) a gum base; and
[0051] (b) a composition including: [0052] (i) at least one active
substance having a first solubility; and [0053] (ii) at least one
taste potentiator having a second solubility,
[0054] wherein the first and second solubilities provide a
controlled-release profile to the chewing gum composition selected
from simultaneous release, sequential release and partially
overlapping release.
[0055] In some embodiments there is a chewing gum composition
including:
[0056] (a) a gum base; and
[0057] (b) a composition comprising an encapsulated mixture of at
least one taste potentiator and at least one active substance.
[0058] In some embodiments there is a chewing gum composition
including:
[0059] (a) a gum base; and
[0060] (b) a composition including: [0061] (i) at least one
encapsulated active substance; and [0062] (ii) at least one taste
potentiator.
[0063] In some embodiments a chewing gum composition includes:
[0064] (a) a gum base; and
[0065] (b) a composition including: [0066] (i) at least one active
substance; and [0067] (ii) at least one taste potentiator.
[0068] In some embodiments there is a chewing gum composition
including:
[0069] (a) a gum base; and
[0070] (b) a composition including: [0071] (i) at least one
encapsulated active substance; and [0072] (ii) at least one
encapsulated taste potentiator.
[0073] In some embodiments there is a chewing gum composition
including:
[0074] (a) a gum base; and
[0075] (b) a composition including: [0076] (i) at least one intense
sweetener; and [0077] (ii) at least one encapsulated sweetener
potentiator.
[0078] Some embodiments provide a chewing gum composition
including:
[0079] (a) a gum base; and
[0080] (b) a sweetener potentiator composition further including:
[0081] (i) a first amount of 3-hydroxybenzoic acid, and [0082] (ii)
a second amount of 2,4-dihydroxybenzoic acid.
[0083] Some embodiments provide a chewing gum composition
including:
[0084] (a) a gum base;
[0085] (b) at least one bulk sweetener; and
[0086] (c) a sweetener potentiator composition further containing:
[0087] (i) a first amount of 3-hydroxybenzoic acid, and [0088] (ii)
a second amount of 2,4-dihydroxybenzoic acid.
[0089] In some embodiments, there is a confectionery composition
including a sweetener potentiator composition, the sweetener
potentiator composition including a first amount of
3-hydroxybenzoic acid and a second amount of 2,4-dihydroxybenzoic
acid, wherein the first amount is equal to the second amount.
[0090] In some embodiments, there is a confectionery composition
including a sweetener potentiator composition, the sweetener
potentiator composition including a first amount of
3-hydroxybenzoic acid and a second amount of 2,4-dihydroxybenzoic
acid.
[0091] Some embodiments provide a confectionery composition
including:
[0092] (a) a confectionery base; and
[0093] (b) a sweetener potentiator composition further containing:
[0094] (i) a first amount of 3-hydroxybenzoic acid, and [0095] (ii)
a second amount of 2,4-dihydroxybenzoic acid.
[0096] In some embodiments, there is a method of reducing the cost
of a sweetener system including the steps of:
[0097] (a) determining an amount of natural or artificial sweetener
in an orally delivered product that provides a desired sweetness
intensity;
[0098] (b) reducing the amount of natural or artificial sweetener;
and
[0099] (c) adding a quantity of a sweetener potentiator composition
including 3-hydroxybenzoic acid and 2,4-dihydroxybenzoic acid such
that the desired sweetness intensity is maintained.
[0100] Some embodiments provide a method of maintaining a desired
sweetness intensity in an orally delivered product including the
steps of:
[0101] (a) determining a desired sweetness intensity;
[0102] (b) adding a quantity of natural or artificial sweetener
that supplies a sweetness intensity less intense than the desired
sweetness intensity; and
[0103] (c) adding a quantity of a sweetener potentiator composition
including 3-hydroxybenzoic acid and 2,4-dihydroxybenzoic acid such
that the desired sweetness intensity is delivered.
[0104] Some embodiments provide a method of increasing the
sweetness intensity of an orally delivered product including the
steps of:
[0105] (a) adding a quantity of natural or artificial sweetener to
an orally delivered product;
[0106] (b) determining a sweetness intensity derived from the
quantity of the natural or artificial sweetener; and
[0107] (c) adding a quantity of a sweetener potentiator composition
including 3-hydroxybenzoic acid and 2,4-dihydroxybenzoic acid such
that the sweetness intensity is greater than the sweetness
intensity derived from the natural or artificial sweetener.
[0108] Some embodiments provide a method of reducing the amount of
natural or artificial sweeteners in an orally delivered product
including the steps of:
[0109] (a) determining an amount of natural or artificial sweetener
in an orally delivered product that provides a desired sweetness
intensity;
[0110] (b) reducing the amount of natural or artificial sweetener;
and
[0111] (c) adding a quantity of a sweetener potentiator composition
including 3-hydroxybenzoic acid and 2,4-dihydroxybenzoic acid such
that the desired sweetness intensity is maintained.
[0112] In some embodiments, a method of preparing a chewing gum
product includes the steps of:
[0113] (a) mixing at least one encapsulant and at least one taste
potentiator to form a dispersion of the components;
[0114] (b) forming a plurality of encapsulated taste potentiator
particles from the mixture;
[0115] (c) adding the encapsulated particles to a chewing gum
composition to enhance the perception of at least one active
substance contained therein, wherein the chewing gum composition
contains a gum base and at least one active substance; and
[0116] (d) forming individual pieces of chewing gum from the
chewing gum composition.
[0117] In some embodiments there is a method of preparing a taste
potentiator composition having controlled-release upon consumption,
which includes the steps of:
[0118] (a) providing at least one taste potentiator;
[0119] (b) mixing the at least one taste potentiator with at least
one encapsulant to form a composition having a dispersion of the
components; and
[0120] (c) forming a plurality of encapsulated taste potentiator
particles from the composition, thereby modifying the release rate
of the at least one taste potentiator upon consumption of the
composition.
[0121] In some embodiments there is a method of controlling the
release of a composition, which includes the steps of:
[0122] (a) providing at least one active substance having a first
solubility; and
[0123] (b) adding at least one taste potentiator having a second
solubility, wherein the first and second solubilities are selected
to impart a controlled-release profile to the composition selected
from simultaneous release, sequential release and partially
overlapping release.
BRIEF DESCRIPTION OF THE DRAWINGS
[0124] FIG. 1 is a graph of 3-hydroxybenzoic acid concentration
against perceived sweetness.
[0125] FIG. 2 is a graph of 2,4-dihydroxybenzoic acid concentration
against perceived sweetness.
[0126] FIG. 3 is a bar chart of sucrose reduction for solutions
containing 3-hydroxybenzoic acid and 2,4-dihydroxybenzoic acid in a
number of different ratios.
[0127] FIG. 4 is a bar chart of sucrose reduction for solutions
containing 3-hydroxybenzoic acid and 2,4-dihydroxybenzoic acid at a
number of different concentrations.
[0128] FIG. 5 is a bar chart of perceived sweetness for a number of
solutions containing substituted benzoic acids.
[0129] FIG. 6 is a bar chart of perceived sweetness for a number of
solutions containing substituted benzoic acids.
[0130] FIG. 7 is a bar chart of perceived sweetness for a number of
solutions containing 3-hydroxybenzoic acid, 2,4-dihydroxybenzoic
acid and 3,4-dihydroxybenzoic acid, in various combinations.
[0131] FIG. 8 is a graph of perceived sweetness for sucrose
solutions containing 2,4-dihydroxybenzoic acid, its potassium salt
or its sodium salt against sucrose concentration.
[0132] FIG. 9 is a bar chart of perceived sweetness for solutions
containing intense sweeteners.
[0133] FIG. 10 is a bar chart of perceived sweetness for solutions
containing bulk sweeteners.
DETAILED DESCRIPTION
[0134] As used herein the transitional term "comprising," (also
"comprises," etc.) which is synonymous with "including,"
"containing," or "characterized by," is inclusive or open-ended and
does not exclude additional, unrecited elements or method steps,
regardless of its use in the preamble or the body of a claim.
[0135] As used herein, the terms "bubble gum" and "chewing gum" are
used interchangeably and are both meant to include any gum
compositions.
[0136] As used herein, the term "confectionery base" includes any
ingredient or group of ingredients that represent form the bulk of
the confectionery composition and provide the confectionery
composition with its structural integrity and to which other
ingredients are added.
[0137] The term "flavor key" as used herein is a flavor component
containing flavoring agents such as flavored oils, and the like,
and is typically used to prepare a flavor essence.
[0138] The term "flavor essence" ("flavor blend", "flavor extract")
as used herein is a flavor component generally prepared from a
flavor key.
[0139] Embodiments described herein provide compositions for oral
delivery of an active substance. Numerous different active
substances may be employed, such as, for example, flavors. The
compositions also may include a taste potentiator. The taste
potentiator may act in a synergistic manner when used in
conjunction with the active substance to enhance the perception of
the active substance during consumption. Additionally, in some
embodiments, the taste potentiator may be encapsulated to provide a
controlled release profile, i.e., delayed or increased rate of
release upon consumption. The taste potentiator accordingly may
release over an extended period of time throughout the consumption
of the product into which the composition is incorporated, such as,
for example, chewing gum.
Potentiator Compositions
[0140] Embodiments described herein provide compositions that may
include at least one active substance and at least one taste
potentiator. The potentiator compositions may have
controlled-release properties. The taste potentiator(s) may work
synergistically with the active substance(s) to enhance the
perception of the active(s). For instance, in some embodiments, the
active substance may be a sweetener. Delivery of the sweetener in
combination with at least one taste potentiator may enhance the
sweet taste upon consumption of the composition. In particular, the
taste potentiator(s) may function synergistically with the
sweetener to enhance the sweet taste. The incorporation of the
potentiator(s), therefore, allows for reduced amounts of sweetener
without compromising the level of sweetness provided by the
composition. Due to the calories contained in many conventional
sweeteners, such as sugar, these results may be highly desirable.
Additionally, there may be significant cost savings associated with
the reduction in sweetener amounts used in the composition.
[0141] For purposes of some embodiments described herein, "taste
potentiator" refers to substances that may enhance the perception
of an active substance during consumption of the composition. For
purposes of some embodiments described herein, the term "enhance"
means to intensify, supplement, modify, modulate or potentiate.
Some taste potentiators may be referred to more specifically by
reference to the type of active they enhance. For example,
sweetener (or sweetness) potentiators enhance the perception of a
sweetener during consumption and flavor potentiators enhance the
perception of a flavor during consumption. These more specific
examples, however, are merely subsets of taste potentiators and are
encompassed by the general term "taste potentiator" as used
herein.
[0142] Taste potentiators may have a synergistic effect when used
in conjunction with an active, i.e., by enhancing the taste effects
of the active substance such that the total effect is greater than
the sum of the taste effects of the individual substances alone. In
addition, some taste potentiators do not introduce a characteristic
taste and/or aroma perception of their own.
[0143] In some embodiments, for instance, the taste potentiator(s)
may enhance the sour, sweet, bitter, salty or umami taste of a
composition. The taste potentiator(s) also may function to enhance
the effects of a variety of other active substances, as discussed
in more detail below.
[0144] Any of a variety of known substances that function as taste
potentiators may be employed in the compositions described herein.
For instance, suitable taste potentiators include water-soluble
taste potentiators, such as, but not limited to, neohesperidin
dihydrochalcone, chlorogenic acid, alapyridaine, cynarin,
miraculin, glupyridaine, pyridinium-betain compounds, glutamates,
such as monosodium glutamate and monopotassium glutamate, neotame,
thaumatin, tagatose, trehalose, salts, such as sodium chloride,
monoammonium glycyrrhizinate, vanilla extract (in ethyl alcohol),
water-soluble sugar acids, potassium chloride, sodium acid sulfate,
water-soluble hydrolyzed vegetable proteins, water-soluble
hydrolyzed animal proteins, water-soluble yeast extracts, adenosine
monophosphate (AMP), glutathione, water-soluble nucleotides, such
as inosine monophosphate, disodium inosinate, xanthosine
monophosphate, guanylate monophosphate, alapyridaine
(N-(1-carboxyethyl)-6-(hydroxymethyl)pyridinium-3-ol inner salt,
sugar beet extract (alcoholic extract), sugarcane leaf essence
(alcoholic extract), curculin, strogin, mabinlin, gymnemic acid,
2-hydroxybenzoic acid (2-HB), 3-hydroxybenzoic acid (3-HB),
4-hydroxybenzoic acid (4-HB), 2,3-dihydroxybenzoic acid (2,3-DHB),
2,4-dihydroxybenzoic acid (2,4-DHB), 2,5-dihydroxybenzoic acid
(2,5-DHB), 2,6-dihydroxybenzoic acid (2,6-DHB),
3,4-dihydroxybenzoic acid (3,4-DHB), 3,5-dihydroxybenzoic acid
(3,5-DHB), 2,3,4-trihydroxybenzoic acid (2,3,4-THB),
2,4,6-trihydroxybenzoic acid (2,4,6-THB), 3,4,5-trihydroxybenzoic
acid (3,4,5-THB), 4-hydroxyphenylacetic acid, 2-hydroxyisocaproic
acid, 3-hydroxycinnamic acid, 3-aminobenzoic acid, 4-aminobenzoic
acid and combinations thereof.
[0145] Other suitable taste potentiators are substantially or
completely insoluble in water, such as, but not limited to, citrus
aurantium, vanilla oleoresin, water insoluble sugar acids, water
insoluble hydrolyzed vegetable proteins, water insoluble hydrolyzed
animal proteins, water insoluble yeast extracts, insoluble
nucleotides, sugarcane leaf essence and combinations thereof.
[0146] Some other suitable taste potentiators include substances
that are slightly soluble in water, such as, but not limited to,
maltol, ethyl maltol, vanillin, slightly water-soluble sugar acids,
slightly water-soluble hydrolyzed vegetable proteins, slightly
water-soluble hydrolyzed animal proteins, slightly water-soluble
yeast extracts, slightly water-soluble nucleotides and combinations
thereof.
[0147] Additional suitable taste potentiators include, but are not
limited to, licorice glycyrrhizinates, compounds that respond to
G-protein coupled receptors (T2R5 and T1R5), G-protein coupled
receptors (T2R5 and T1R5) and taste potentiator compositions that
impart kokumi, as disclosed in U.S. Pat. No. 5,679,397 to Kuroda et
al., which is incorporated in its entirety herein by reference.
"Kokumi" refers to materials that impart "mouthfulness" and "good
body". Kokumi imparting compositions may be water-soluble, slightly
water-soluble or insoluble in water.
[0148] As mentioned above, sweetener potentiators, which are a type
of taste potentiator, enhance the taste of sweetness. Exemplary
sweetener potentiators include, but are not limited to,
monoammonium glycyrrhizinate, licorice glycyrrhizinates, citrus
aurantium, alapyridaine, alapyridaine
(N-(1-carboxyethyl)-6-(hydroxymethyl)pyridinium-3-ol) inner salt,
miraculin, curculin, strogin, mabinlin, gymnemic acid, cynarin,
glupyridaine, pyridinium-betain compounds, sugar beet extract,
neotame, thaumatin, neohesperidin dihydrochalcone, tagatose,
trehalose, maltol, ethyl maltol, vanilla extract, vanilla
oleoresin, vanillin, sugar beet extract (alcoholic extract),
sugarcane leaf essence (alcoholic extract), compounds that respond
to G-protein coupled receptors (T2R5 and T1R5), 2-hydroxybenzoic
acid (2-HB), 3-hydroxybenzoic acid (3-HB), 4-hydroxybenzoic acid
(4-HB), 2,3-dihydroxybenzoic acid (2,3-DHB), 2,4-dihydroxybenzoic
acid (2,4-DHB), 2,5-dihydroxybenzoic acid (2,5-DHB),
2,6-dihydroxybenzoic acid (2,6-DHB), 3,4-dihydroxybenzoic acid
(3,4-DHB), 3,5-dihydroxybenzoic acid (3,5-DHB),
2,3,4-trihydroxybenzoic acid (2,3,4-THB), 2,4,6-trihydroxybenzoic
acid (2,4,6-THB), 3,4,5-trihydroxybenzoic acid (3,4,5-THB),
4-hydroxyphenylacetic acid, 2-hydroxyisocaproic acid,
3-hydroxycinnamic acid, 3-aminobenzoic acid, 4-aminobenzoic acid
and combinations thereof.
[0149] Additional taste potentiators for the enhancement of salt
taste include acidic peptides, such as those disclosed in U.S. Pat.
No. 6,974,597, herein incorporated by reference. Acidic peptides
include peptides having a larger number of acidic amino acids, such
as aspartic acid and glutamic acid, than basic amino acids, such as
lysine, arginine and histidine. The acidic peptides are obtained by
peptide synthesis or by subjecting proteins to hydrolysis using
endopeptidase, and if necessary, to deamidation. Suitable proteins
for use in the production of the acidic peptides or the peptides
obtained by subjecting a protein to hydrolysis and deamidation
include plant proteins, (e.g. wheat gluten, corn protein (e.g.,
zein and gluten meal), soybean protein isolate), animal proteins
(e.g., milk proteins such as milk casein and milk whey protein,
muscle proteins such as meat protein and fish meat protein, egg
white protein and collagen), and microbial proteins (e.g.,
microbial cell protein and polypeptides produced by
microorganisms).
[0150] The sensation of warming or cooling effects may also be
prolonged with the use of a hydrophobic sweetener as described in
U.S. Patent Publication No. 2003/0072842 A1, which is incorporated
in its entirety herein by reference. For example, such hydrophobic
sweeteners include those of the formulae I-XI as set forth
below:
##STR00001##
wherein X, Y and Z are selected from the group consisting of
CH.sub.2, O and S;
##STR00002##
wherein X and Y are selected from the group consisting of S and
O;
##STR00003##
wherein X is S or O; Y is O or CH.sub.2; Z is CH.sub.2, SO.sub.2 or
S; R is OCH.sub.3, OH or H; R.sup.1 is SH or OH and R.sup.2 is H or
OH;
##STR00004##
wherein X is C or S; R is OH or H and R.sup.1 is OCH.sub.3 or
OH;
##STR00005##
wherein R, R.sup.2 and R.sup.3 are OH or H and R.sup.1 is H or
COOH;
##STR00006##
wherein X is O or CH.sub.2 and R is COOH or H;
##STR00007##
wherein R is CH.sub.3CH.sub.2, OH, N(CH.sub.3).sub.2 or Cl;
##STR00008##
[0151] Perillartine may also be added as described in U.S. Pat. No.
6,159,509 also incorporated in its entirety herein by
reference.
[0152] Any of the above-listed taste potentiators may be used alone
or in combination.
[0153] Some embodiments, for instance, may include two or more
taste potentiators that act synergistically with one another. For
instance, in some embodiments, a sweetener potentiator composition
may be provided, which includes two or more sweetener potentiators
that act synergistically with one another. The sweetener
potentiator composition may enhance the sweetness of products into
which it is incorporated by reducing the amount of sucrose needed
to provide a sweetness intensity equivalent to sucrose. The
sweetness enhancing effect of the combination of sweetener
potentiators may be greater than the effect of either compound used
individually.
[0154] More specifically, according to some embodiments, there is
provided a sweetener potentiator composition comprising
3-hydroxybenzoic acid (3-HB) and 2,4-dihydroxybenzoic acid
(2,4-DHB) or comestible salts thereof.
[0155] Comestible salts include acid (i.e. carboxylate) salts
and/or hydroxylate salts, especially sodium, potassium, calcium,
magnesium, and ammonium salts and the like. Desirably, in some
embodiments, the sweetener potentiator composition employs 3-HB
and/or 2,4-DHB in the form of the acid, the sodium salt or the
potassium salt.
[0156] Although 3-HB and 2,4-DHB have been studied individually,
they have not been used in combination. The inventors have
discovered that a surprisingly large sweetness enhancing effect is
observed when both compounds are employed in combination with a
sweetener. This effect is greater than would be predicted by the
use of either compound individually.
[0157] In particular, in some embodiments, sufficient amounts of
3-HB and 2,4-DHB are employed in the sweetener potentiator
compositions to create a sucrose equivalent value of at least about
seven %, more specifically, at least about eight %.
[0158] In general, 3-HB and 2,4-DHB may be used in amounts of about
200 ppm, 400 ppm or 500 ppm. 3-HB and 2,4-DHB may be incorporated
into sweetener potentiator compositions in equal or different
amounts.
[0159] In some embodiments, the sweetener potentiator composition
contains 3-HB and 2,4-DHB in a ratio by weight of from 1:9 to 9:1,
more specifically from 2:8 to 8:2, even more specifically from 4:6
to 6:4 and most specifically 1:1.
[0160] The sweetener potentiator composition may contain a further
sweetener potentiator. For instance, 3,4-dihydroxybenzoic acid
(3,4-DHB) or its comestible salt may be employed.
[0161] In some embodiments, the sweetener potentiator composition
may be provided as a pre-blended powder or liquid, which may be
added to another composition, whereas in other embodiments, the
individual components of the sweetener potentiator composition may
be added to another composition as individual ingredients.
[0162] In some embodiments, it may be desirable to control the
release rate of the taste potentiator(s) from the compositions, as
well as the overall release profile of the compositions themselves.
Different release rates may be desired depending on the type of
final product in which the composition is being incorporated and
the consumption time thereof. For instance, chewing gum products
may have different chew profiles, ranging anywhere from about 15 to
about 120 minutes. Depending upon the chewing gum selected,
different release rates will be desired. Other confectionery
formats, such as hard candy, including nougats, caramels, frappes
and taffies, also may have different release rates.
[0163] In some embodiments, the release rate may be based on the
solubility of the taste potentiator(s) in water. Selection of a
specific solubility may be used to control the release profile of
the taste potentiator(s), as well as the overall composition. More
specifically, taste potentiators have varying solubilities in
water. Although some of these components are water-soluble, i.e.,
capable of being substantially or completely dissolvable in water,
others exhibit poor or no solubility in water. In some embodiments,
for instance, it may be desirable to select one or more taste
potentiators that have low water-solubility in combination with an
active known to exhibit poor solubility in water. The highly
insoluble taste potentiator thereby may last throughout consumption
of the composition as the active substance also slowly releases
therefrom. Alternatively, a relatively highly water-soluble
potentiator may be paired with a relatively highly water-soluble
active substance. In both of these instances, the taste potentiator
and active substance may be selected based on solubilities such
that their release profiles are similar or overlap.
[0164] In other embodiments, for example, it may be desirable to
select several taste potentiators that have different solubilities
in water such that the potentiators may release sequentially from
the composition. Another example may include multiple sequentially
releasing taste potentiators with multiple active substances also
having different solubilities in water. Numerous other combinations
of taste potentiators having different solubilities also may be
used to provide different release profiles for the compositions. In
view thereof, the solubility of the taste potentiator(s), as well
as the combination thereof with the active(s), may be used to
control and tailor the release profile of the overall
composition.
[0165] For purposes of some embodiments described herein,
therefore, the term "controlled-release" means that the duration or
manner of release is managed or modified to some degree to provide
a desired release profile. More specifically, for example,
controlled-release includes at least the following release
profiles: delayed onset of release; pulsed release; gradual
release; high initial release; sustained release; sequential
release; and combinations thereof.
[0166] Taste potentiators and active substances having different
solubilities and/or release profiles may be combined in numerous
different embodiments to provide compositions having many different
overall release profiles. For example, one or more taste
potentiators having any of the following release profiles may be
combined in any manner with one or more active substances having
any of the following release profiles: delayed onset of release
("DOR"); pulsed release ("PR"); gradual release ("GR"); high
initial release ("HIR"); and sustained release ("SUR"). Moreover,
other techniques of imparting these, as well as other
controlled-release profiles to taste potentiators and/or active
substances may be employed. For instance, encapsulation techniques,
which are discussed in more detail below, may be used.
Additionally, taste potentiator(s) and active substance(s) that are
not encapsulated (sometimes referred to as "free" components) may
be combined with other forms of the components, such as
encapsulated forms, to tailor the release profile of the
potentiator compositions. A sampling of hypothetical combinations
is provided in Table 1 below, wherein P.sub.1-P.sub.3 represent
different taste potentiators and A.sub.1-A.sub.3 represent
different active substances. P.sub.1-P.sub.3 and A.sub.1-A.sub.3
may be used in their free and/or encapsulated forms.
TABLE-US-00001 TABLE 1 Hypothetical Combinations P.sub.1 P.sub.2
P.sub.3 A.sub.1 A.sub.2 A.sub.3 1 GR HIR GR HIR 2 GR HIR GR HIR 3
PR SUR GR PR SUR GR 4 PR SUR PR SUR 5 HI PR HI PR 6 DOR HIR DOR HIR
7 DOR HIR DOR HIR 8 DOR PR DOR 9 SUR HIR PR 10 SUR HIR PR
[0167] Controlled-release properties also may be imparted to the
compositions described herein in other manners, such as, for
example, by encapsulation techniques, as mentioned above.
Encapsulation may be used to impart any of the various release
profiles discussed above. In some embodiments, the taste
potentiator(s) and/or active substance(s) may be encapsulated to
control the rate of release of the potentiator and/or active from
the composition. For example, in some embodiments, 3-HB and/or
2,4-DHB may be used in their encapsulated forms.
[0168] For instance, some embodiments may include at least one
encapsulated taste potentiator and at least one unencapsulated
active, i.e., in its free form. Other embodiments may include at
least one unencapsulated taste potentiator and at least one
encapsulated active substance. Further, in some embodiments, both
the taste potentiator(s) and active substance(s) may be
encapsulated. In such embodiments, the taste potentiator(s) and
active substance(s) may be encapsulated together or separately. In
embodiments in which the taste potentiator(s) and active
substance(s) are encapsulated separately, the material used to
encapsulate the components may be the same or different.
Furthermore, in any of these embodiments, more than one material
may be used to encapsulate the taste potentiator(s) or the active
substance(s).
[0169] In any of the embodiments mentioned above, the encapsulated
form of the taste potentiator(s) or active substance(s) may be used
in combination with an amount of the same component in its free,
i.e., unencapsulated, form. By using both the free component and
the encapsulated component, the enhanced perception of the active
may be provided over a longer period of time and/or perception of
the active by a consumer may be improved. For instance, some
embodiments may include a taste potentiator that is encapsulated in
combination with an amount of the same taste potentiator in its
unencapsulated form. Alternatively, the unencapsulated taste
potentiator could be a different taste potentiator from the
potentiator that is encapsulated. Thereby, a mixture of two
different taste potentiators may be included in some embodiments,
one of which is encapsulated and the other in its free form. These
variations also may be employed with respect to the active
substance(s).
[0170] Encapsulation may be effected by dispersion of the
components, spray drying, spray coating, fluidized bed drying,
absorption, adsorption, coacervation, complexation, or any other
standard technique. In general, the taste potentiator(s) and/or
active substances(s) may be encapsulated by an encapsulant. For
purposes of some embodiments described herein, the term
"encapsulant" refers to a material that can fully or partially coat
or enrobe another substance. Encapsulation is also meant to include
adsorption of a substance onto another substance and the formation
of agglomerates or conglomerates between two substances.
[0171] Any material conventionally used as an encapsulant in edible
products may be employed. In some embodiments, for instance, it may
be desirable to use an encapsulant that delays the release of the
taste potentiator(s), such as, for example, a hydrophobic
encapsulant. In contrast, in other embodiments, it may be desirable
to increase the rate of release by using an encapsulant such as,
for example, a hydrophilic material. Moreover, more than one
encapsulant may be used. For example, a taste potentiator or an
active substance may be encapsulated by a mixture of two or more
encapsulants to tailor the rate of release.
[0172] It is believed that taste potentiators can act in
conjunction with active substances to enhance their activity. In
some embodiments, therefore, it may be desirable to control the
release of the potentiator(s) such that it substantially coincides
with that of the active substance(s) included in the composition.
As discussed above, some taste potentiators have rapid release
rates, whereas other taste potentiators have slower release rates.
Meanwhile, some active substances have rapid release rates, whereas
others have slower release rates. In some embodiments, the material
used to encapsulate the taste potentiator(s) may be selected to
delay or increase the release rate of the potentiator(s) based on
the release profiles of both the potentiator(s) and active
substance(s) selected for use together in the composition.
[0173] More specifically, in some embodiments, the active
substance(s) contained in the composition may have a slower release
profile than the taste potentiator(s) selected for use in the same
composition. It may be desirable, therefore, to delay the release
of the taste potentiator(s) from the composition such that it
releases substantially in conjunction with the active(s). The
corresponding release profile may increase the effectiveness of the
taste potentiator(s) in enhancing the perception of the active(s)
throughout consumption.
[0174] Suitable encapsulants for use in delayed release embodiments
include, but are not limited to, polyvinyl acetate, polyethylene,
crosslinked polyvinyl pyrrolidone, polymethylmethacrylate,
polylactidacid, polyhydroxyalkanoates, ethylcellulose, polyvinyl
acetatephthalate, methacrylicacid-co-methylmethacrylate and
combinations thereof.
[0175] In some embodiments, as mentioned above, the taste
potentiator(s) may be water-soluble. For example, the following
taste potentiators are water-soluble: neohesperidin
dihydrochalcone, chlorogenic acid, alapyridaine, cynarin,
miraculin, glupyridaine, pyridinium-betain compounds, glutamates,
such as monosodium glutamate and monopotassium glutamate, neotame,
thaumatin, tagatose, trehalose, salts, such as sodium chloride,
monoammonium glycyrrhizinate, vanilla extract (in ethyl alcohol),
water-soluble sugar acids, potassium chloride, sodium acid sulfate,
water-soluble hydrolyzed vegetable proteins, water-soluble
hydrolyzed animal proteins, water-soluble yeast extracts, adenosine
monophosphate (AMP), glutathione, water-soluble nucleotides, such
as inosine monophosphate, disodium inosinate, xanthosine
monophosphate, guanylate monophosphate, alapyridaine
(N-(1-carboxyethyl)-6-(hydroxymethyl)pyridinium-3-ol inner salt,
sugar beet extract (alcoholic extract), sugarcane leaf essence
(alcoholic extract), curculin, strogin, mabinlin, gymnemic acid,
2-hydroxybenzoic acid (2-HB), 3-hydroxybenzoic acid (3-HB),
4-hydroxybenzoic acid (4-HB), 2,3-dihydroxybenzoic acid (2,3-DHB),
2,4-dihydroxybenzoic acid (2,4-DHB), 2,5-dihydroxybenzoic acid
(2,5-DHB), 2,6-dihydroxybenzoic acid (2,6-DHB),
3,4-dihydroxybenzoic acid (3,4-DHB), 3,5-dihydroxybenzoic acid
(3,5-DHB), 2,3,4-trihydroxybenzoic acid (2,3,4-THB),
2,4,6-trihydroxybenzoic acid (2,4,6-THB), 3,4,5-trihydroxybenzoic
acid (3,4,5-THB), 4-hydroxyphenylacetic acid, 2-hydroxyisocaproic
acid, 3-hydroxycinnamic acid, 3-aminobenzoic acid, 4-aminobenzoic
acid and combinations thereof. Due to their water-solubility, such
taste potentiators may tend to release rapidly from the
compositions into which they are incorporated. As such, in some
embodiments, water-soluble taste potentiators may be encapsulated
by an encapsulant that delays the release of the potentiator(s), as
provided above.
[0176] In other embodiments, it may be desirable to increase the
release of the taste potentiator(s) from the composition. For
instance, the taste potentiator(s) included in the composition may
have a slower release rate than the active substance(s) selected
for use in combination therewith. This difference in release rates
may reduce the effectiveness of the taste potentiator(s).
Accordingly, such taste potentiators may be encapsulated with an
encapsulant that increases the rate of the potentiator's release.
Thereby, the release of the potentiator(s) and the active(s) may
substantially coincide during consumption.
[0177] Suitable encapsulants for use in increased release
embodiments include, but are not limited to, cyclodextrins, sugar
alcohols, starch, gum arabic, polyvinylalcohol, polyacrylic acid,
gelatin, guar gum, fructose and combinations thereof.
[0178] In some embodiments, as mentioned above, the taste
potentiator(s) may be substantially or completely insoluble in
water. For example, the following taste potentiators are
substantially or completely water-insoluble: citrus aurantium,
vanilla oleoresin, water insoluble sugar acids, water insoluble
hydrolyzed vegetable proteins, water insoluble hydrolyzed animal
proteins, water insoluble yeast extracts, insoluble nucleotides,
sugarcane leaf essence and combinations thereof. Due to their poor
solubility in water, such taste potentiators may tend to release
slowly from the compositions. As such, in some embodiments,
substantially or completely water-insoluble taste potentiators may
be encapsulated by an encapsulant that increases the release of the
potentiator(s), as provided above.
[0179] In accordance with the above, the encapsulated taste
potentiator may include a taste potentiator and an encapsulant. The
encapsulant may be selected based upon the desired release profile
of the taste potentiator. In some embodiments, the taste
potentiator(s) may be present in amounts of about 0.01% to about
10% by weight of the composition, more specifically about 0.1% to
about 2% by weight of the composition.
[0180] In some embodiments, the encapsulant may be present in
amounts of about 1% to about 95% by weight of the composition, more
specifically about 5% to about 30% by weight of the
composition.
[0181] In some embodiments, the encapsulated substance, i.e.
encapsulated taste potentiator(s) or active(s), may have a high
tensile strength, such as at least about 6,500 psi. More
specifically, the tensile strength may be about 6,500 psi to about
200,000 psi. Such tensile strengths may be suitable for controlling
the release of the taste potentiator(s) and/or active substance(s)
in a consistent manner over an extended period of time. Tensile
strengths of encapsulated substances are described in more detail
in U.S. Patent Publication No. 2005/0112236 A1, the contents of
which are incorporated by reference herein.
[0182] In some embodiments, the active substance(s) included in the
potentiator compositions may be present in amounts of about 1% to
about 95% by weight of the composition, more specifically about 5%
to about 30% by weight of the composition.
[0183] The active substance(s) may be any component for which the
perception is enhanced in some manner by the presence of one or
more taste potentiators. Suitable active substances include, but
are not limited to, compounds that provide flavor, sweetness,
tartness, umami, kokumi, savory, saltiness, cooling, warmth or
tingling. Other suitable actives include oral care agents,
nutraceutical actives and pharmaceutical actives. Combinations of
active substances also may be employed.
[0184] Compounds that provide flavor (flavorings or flavor agents),
which may be used include those flavors known to the skilled
artisan, such as natural and artificial flavors. These flavorings
may be chosen from synthetic flavor oils and flavoring aromatics
and/or oils, oleoresins and extracts derived from plants, leaves,
flowers, fruits, and so forth, and combinations thereof.
Nonlimiting representative flavor oils include spearmint oil,
cinnamon oil, oil of wintergreen (methyl salicylate), peppermint
oil, Japanese mint oil, clove oil, bay oil, anise oil, eucalyptus
oil, thyme oil, cedar leaf oil, oil of nutmeg, allspice, oil of
sage, mace, oil of bitter almonds, and cassia oil. Also useful
flavorings are artificial, natural and synthetic fruit flavors such
as vanilla, and citrus oils including lemon, orange, lime,
grapefruit, yazu, sudachi, and fruit essences including apple,
pear, peach, grape, blueberry, strawberry, raspberry, cherry, plum,
pineapple, watermelon, apricot, banana, melon, apricot, ume,
cherry, raspberry, blackberry, tropical fruit, mango, mangosteen,
pomegranate, papaya and so forth. Other potential flavors include a
milk flavor, a butter flavor, a cheese flavor, a cream flavor, and
a yogurt flavor; a vanilla flavor; tea or coffee flavors, such as a
green tea flavor, a oolong tea flavor, a tea flavor, a cocoa
flavor, a chocolate flavor, and a coffee flavor; mint flavors, such
as a peppermint flavor, a spearmint flavor, and a Japanese mint
flavor; spicy flavors, such as an asafetida flavor, an ajowan
flavor, an anise flavor, an angelica flavor, a fennel flavor, an
allspice flavor, a cinnamon flavor, a chamomile flavor, a mustard
flavor, a cardamom flavor, a caraway flavor, a cumin flavor, a
clove flavor, a pepper flavor, a coriander flavor, a sassafras
flavor, a savory flavor, a Zanthoxyli Fructus flavor, a perilla
flavor, a juniper berry flavor, a ginger flavor, a star anise
flavor, a horseradish flavor, a thyme flavor, a tarragon flavor, a
dill flavor, a capsicum flavor, a nutmeg flavor, a basil flavor, a
marjoram flavor, a rosemary flavor, a bayleaf flavor, and a wasabi
(Japanese horseradish) flavor; alcoholic flavors, such as a wine
flavor, a whisky flavor, a brandy flavor, a rum flavor, a gin
flavor, and a liqueur flavor; floral flavors; and vegetable
flavors, such as an onion flavor, a garlic flavor, a cabbage
flavor, a carrot flavor, a celery flavor, mushroom flavor, and a
tomato flavor. These flavoring agents may be used in liquid or
solid form and may be used individually or in admixture. Commonly
used flavors include mints such as peppermint, menthol, spearmint,
artificial vanilla, cinnamon derivatives, and various fruit
flavors, whether employed individually or in admixture. Flavors may
also provide breath freshening properties, particularly the mint
flavors when used in combination with cooling agents.
[0185] Other useful flavorings include aldehydes and esters such as
cinnamyl acetate, cinnamaldehyde, citral diethylacetal,
dihydrocarvyl acetate, eugenyl formate, p-methylamisol, and so
forth may be used. Generally any flavoring or food additive such as
those described in Chemicals Used in Food Processing, publication
1274, pages 63-258, by the National Academy of Sciences, may be
used. This publication is incorporated herein by reference.
[0186] Further examples of aldehyde flavorings include but are not
limited to acetaldehyde (apple), benzaldehyde (cherry, almond),
anisic aldehyde (licorice, anise), cinnamic aldehyde (cinnamon),
citral, i.e., alpha-citral (lemon, lime), neral, i.e., beta-citral
(lemon, lime), decanal (orange, lemon), ethyl vanillin (vanilla,
cream), heliotrope, i.e., piperonal (vanilla, cream), vanillin
(vanilla, cream), alpha-amyl cinnamaldehyde (spicy fruity flavors),
butyraldehyde (butter, cheese), valeraldehyde (butter, cheese),
citronellal (modifies, many types), decanal (citrus fruits),
aldehyde C-8 (citrus fruits), aldehyde C-9 (citrus fruits),
aldehyde C-12 (citrus fruits), 2-ethyl butyraldehyde (berry
fruits), hexenal, i.e., trans-2 (berry fruits), tolyl aldehyde
(cherry, almond), veratraldehyde (vanilla),
2,6-dimethyl-5-heptenal, i.e., melonal (melon), 2,6-dimethyloctanal
(green fruit), and 2-dodecenal (citrus, mandarin), cherry, grape,
strawberry shortcake, and mixtures thereof.
[0187] In some embodiments, the flavor agent may be employed in
either liquid form and/or dried form. When employed in the latter
form, suitable drying means such as spray drying the oil may be
used. Alternatively, the flavor agent may be absorbed onto water
soluble materials, such as cellulose, starch, sugar, maltodextrin,
gum arabic and so forth or may be encapsulated. The actual
techniques for preparing such dried forms are well-known.
[0188] In some embodiments, the flavor agents may be used in many
distinct physical forms well-known in the art to provide an initial
burst of flavor and/or a prolonged sensation of flavor. Without
being limited thereto, such physical forms include free forms, such
as spray dried, powdered, beaded forms, encapsulated forms, and
mixtures thereof.
[0189] Compounds that provide sweetness (sweeteners or sweetening
agents) may include bulk sweeteners such as sugars, sugarless bulk
sweeteners, or the like, or mixtures thereof.
[0190] Suitable sugar sweeteners generally include
mono-saccharides, di-saccharides and poly-saccharides such as but
not limited to, sucrose (sugar), dextrose, maltose, dextrin,
xylose, ribose, glucose, lactose, mannose, galactose, fructose
(levulose), invert sugar, fructo oligo saccharide syrups, partially
hydrolyzed starch, corn syrup solids, isomaltulose and mixtures
thereof.
[0191] Suitable sugarless bulk sweeteners include sugar alcohols
(or polyols) such as, but not limited to, sorbitol, xylitol,
mannitol, galactitol, maltitol, hydrogenated isomaltulose
(ISOMALT), lactitol, erythritol, hydrogenated starch hydrolysate,
stevia and mixtures thereof.
[0192] Suitable hydrogenated starch hydrolysates include those
disclosed in U.S. Pat. No. 4,279,931 and various hydrogenated
glucose syrups and/or powders which contain sorbitol, maltitol,
hydrogenated disaccharides, hydrogenated higher polysaccharides, or
mixtures thereof. Hydrogenated starch hydrolysates are primarily
prepared by the controlled catalytic hydrogenation of corn syrups.
The resulting hydrogenated starch hydrolysates are mixtures of
monomeric, dimeric, and polymeric saccharides. The ratios of these
different saccharides give different hydrogenated starch hydro
lysates different properties. Mixtures of hydrogenated starch
hydrolysates, such as LYCASIN.RTM., a commercially available
product manufactured by Roquette Freres of France, and HYSTAR.RTM.,
a commercially available product manufactured by SPI Polyols, Inc.
of New Castle, Del., are also useful.
[0193] In some embodiments, high-intensity sweeteners may be used.
Without being limited to particular sweeteners, representative
categories and examples include:
[0194] (a) water-soluble sweetening agents such as
dihydrochalcones, monellin, stevia, steviosides, rebaudioside A,
glycyrrhizin, dihydroflavenol, and sugar alcohols such as sorbitol,
mannitol, maltitol, xylitol, erythritol and L-aminodicarboxylic
acid aminoalkenoic acid ester amides, such as those disclosed in
U.S. Pat. No. 4,619,834, which disclosure is incorporated herein by
reference, and mixtures thereof;
[0195] (b) water-soluble artificial sweeteners such as soluble
saccharin salts, i.e., sodium or calcium saccharin salts, cyclamate
salts, the sodium, ammonium or calcium salt of
3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, the
potassium salt of
3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide
(Acesulfame-K), the free acid form of saccharin, and mixtures
thereof;
[0196] (c) dipeptide based sweeteners, such as L-aspartic acid
derived sweeteners, such as L-aspartyl-L-phenylalanine methyl ester
(Aspartame) and materials described in U.S. Pat. No. 3,492,131,
L-alphaaspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamide
hydrate (Alitame),
N--[N-(3,3-dimethylbutyl)-L-aspartyl]-L-phenylalanine 1-methyl
ester (Neotame), methyl esters of L-aspartyl-L-phenylglycerine and
L-aspartyl-L-2,5-dihydrophenyl-glycine,
L-aspartyl-2,5-dihydro-L-phenylalanine;
L-aspartyl-L-(1-cyclohexen)-alanine, and mixtures thereof;
[0197] (d) water-soluble sweeteners derived from naturally
occurring water-soluble sweeteners, such as chlorinated derivatives
of ordinary sugar (sucrose), e.g., chlorodeoxysugar derivatives
such as derivatives of chlorodeoxysucrose or
chlorodeoxygalactosucrose, known, for example, under the product
designation of Sucralose; examples of chlorodeoxysucrose and
chlorodeoxygalactosucrose derivatives include but are not limited
to: 1-chloro-1'-deoxysucrose;
4-chloro-4-deoxy-alpha-D-galactopyranosyl-alpha-D-fructofuranoside,
or 4-chloro-4-deoxygalactosucrose;
4-chloro-4-deoxy-alpha-D-galactopyranosyl-1-chloro-1-deoxy-beta-D-fructo--
furanoside, or 4,1'-dichloro-4,1'-dideoxygalactosucrose;
1',6'-dichloro1,6'-dideoxysucrose;
4-chloro-4-deoxy-alpha-D-galactopyranosyl-1,6-dichloro-1,6-dideoxy-beta-D-
-fructofuranoside, or
4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose;
4,6-dichloro-4,6-dideoxy-alpha-D-galactopyranosyl-6-chloro-6-deoxy-beta-D-
-fructofuranoside, or
4,6,6'-trichloro-4,6,6'-trideoxygalactosucrose;
6,1',6'-trichloro-6,1',6'-trideoxysucrose;
4,6-dichloro-4,6-dideoxy-alpha-D-galacto-pyranosyl-1,6-dichloro-1,6-dideo-
xy-beta-D-fructofuranoside, or
4,6,1',6'-tetrachloro-4,6,1',6'-tetradeoxygalacto-sucrose; and
4,6,1',6'-tetradeoxy-sucrose, and mixtures thereof;
[0198] (e) protein based sweeteners such as thaumatococcus danielli
(Thaumatin I and II) and talin;
[0199] (f) the sweetener monatin
(2-hydroxy-2-(indol-3-ylmethyl)-4-aminoglutaric acid) and its
derivatives; and
[0200] (g) the sweetener Lo han guo (sometimes also referred to as
"Lo han kuo").
[0201] The intense sweetening agents may be used in many distinct
physical forms well-known in the art to provide an initial burst of
sweetness and/or a prolonged sensation of sweetness. Without being
limited thereto, such physical forms include free forms, such as
spray dried, powdered, beaded forms, encapsulated forms, and
mixtures thereof.
[0202] Compounds that provide tartness may include acidulants, such
as acetic acid, adipic acid, ascorbic acid, butyric acid, citric
acid, formic acid, fumaric acid, glyconic acid, lactic acid,
phosphoric acid, malic acid, oxalic acid, succinic acid, tartaric
acid and mixtures thereof.
[0203] Compounds that provide umami or savory flavor may include
monosodium glutamate (MSG), glutamic acid, glutamates, aspartate,
free amino acids, IMP (disodium 5'-inosine monophosphate) and GMP
(disodium 5'-guanosine monophosphate), compounds that stimulate
T1R1 and T1R3 receptors, mushroom flavor, fermented fish flavor,
and muscle flavors, such as beef, chicken, pork, ostrich, venison
and buffalo.
[0204] Substances that impart kokumi may include a mixture selected
from: (1) gelatin and tropomyosin and/or tropomyosin peptides; (2)
gelatin and paramyosin; and (3) troponin and tropomyosin and/or
tropomyosin peptides, as disclosed in U.S. Pat. No. 5,679,397 to
Kuroda et al., referred to above.
[0205] Compounds that provide saltiness may include conventional
salts, such as sodium chloride, calcium chloride, potassium
chloride, 1-lysine and combinations thereof.
[0206] Compounds that provide a cooling sensation may include
physiological cooling agents. A variety of well known cooling
agents may be employed. For example, among the useful cooling
agents are included xylitol, erythritol, dextrose, sorbitol,
menthane, menthone, ketals, menthone ketals, menthone glycerol
ketals, substituted p-menthanes, acyclic carboxamides, mono menthyl
glutarate, substituted cyclohexanamides, substituted cyclohexane
carboxamides, substituted ureas and sulfonamides, substituted
menthanols, hydroxymethyl and hydroxymethyl derivatives of
p-menthane, 2-mercapto-cyclo-decanone, hydroxycarboxylic acids with
2-6 carbon atoms, cyclohexanamides, menthyl acetate, menthyl
salicylate, N,2,3-trimethyl-2-isopropyl butanamide (WS-23),
N-ethyl-p-menthane-3-carboxamide (WS-3), isopulegol,
3-(1-menthoxy)propane-1,2-diol,
3-(1-menthoxy)-2-methylpropane-1,2-diol, p-menthane-2,3-diol,
p-menthane-3,8-diol,
6-isopropyl-9-methyl-1,4-dioxaspiro[4,5]decane-2-methanol, menthyl
succinate and its alkaline earth metal salts,
trimethylcyclohexanol,
N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, Japanese mint
oil, peppermint oil, 3-(1-menthoxy)ethan-1-ol,
3-(1-menthoxy)propan-1-ol, 3-(1-menthoxy)butan-1-ol,
1-menthylacetic acid N-ethylamide, 1-menthyl-4-hydroxypentanoate,
1-menthyl-3-hydroxybutyrate,
N,2,3-trimethyl-2-(1-methylethyl)-butanamide, n-ethyl-t-2-c-6
nonadienamide, N,N-dimethyl menthyl succinamide, substituted
p-menthanes, substituted p-menthane-carboxamides,
2-isopropanyl-5-methylcyclohexanol (from Hisamitsu Pharmaceuticals,
hereinafter "isopregol"); menthone glycerol ketals (FEMA 3807,
tradename FRESCOLAT.RTM. type MGA); 3-1-menthoxypropane-1,2-diol
(from Takasago, FEMA 3784); and menthyl lactate; (from Haarman
& Reimer, FEMA 3748, tradename FRESCOLAT.RTM. type ML), WS-30,
WS-14, Eucalyptus extract (p-Mehtha-3,8-Diol), Menthol (its natural
or synthetic derivatives), Menthol PG carbonate, Menthol EG
carbonate, Menthol glyceryl ether,
N-tertbutyl-p-menthane-3-carboxamide, P-menthane-3-carboxylic acid
glycerol ester, Methyl-2-isopryl-bicyclo (2.2.1),
Heptane-2-carboxamide; and Menthol methyl ether, and menthyl
pyrrolidone carboxylate among others. These and other suitable
cooling agents are further described in the following U.S. patents,
all of which are incorporated in their entirety by reference
hereto: U.S. Pat. Nos. 4,230,688; 4,032,661; 4,459,425; 4,136,163;
5,266,592; 6,627,233.
[0207] Compounds that provide warmth (warming agents) may be
selected from a wide variety of compounds known to provide the
sensory signal of warming to the individual user. These compounds
offer the perceived sensation of warmth, particularly in the oral
cavity, and often enhance the perception of flavors, sweeteners and
other organoleptic components. Useful warming agents include those
having at least one allyl vinyl component, which may bind to oral
receptors. Examples of suitable warming agents include, but are not
limited to: vanillyl alcohol n-butylether (TK-1000, supplied by
Takasago Perfumery Company Ltd., Tokyo, Japan); vanillyl alcohol
n-propylether; vanillyl alcohol isopropylether; vanillyl alcohol
isobutylether; vanillyl alcohol n-aminoether; vanillyl alcohol
isoamylether; vanillyl alcohol n-hexylether; vanillyl alcohol
methylether; vanillyl alcohol ethylether; gingerol; shogaol;
paradol; zingerone; capsaicin; dihydrocapsaicin;
nordihydrocapsaicin; homocapsaicin; homodihydrocapsaicin; ethanol;
isopropyl alcohol; iso-amylalcohol; benzyl alcohol; glycerine;
chloroform; eugenol; cinnamon oil; cinnamic aldehyde; phosphate
derivatives thereof; and combinations thereof.
[0208] Compounds that provide a tingling sensation also are known
and referred to as "tingling agents." Tingling agents may be
employed to provide a tingling, stinging or numbing sensation to
the user. Tingling agents include, but are not limited to: Jambu
Oleoresin or para cress (Spilanthes sp.), in which the active
ingredient is Spilanthol; Japanese pepper extract (Zanthoxylum
peperitum), including the ingredients known as Saanshool-I,
Saanshool-II and Sanshoamide; black pepper extract (piper nigrum),
including the active ingredients chavicine and piperine; Echinacea
extract; Northern Prickly Ash extract; and red pepper oleoresin. In
some embodiments, alkylamides extracted from materials such as
jambu or sanshool may be included. Additionally, in some
embodiments, a sensation is created due to effervescence. Such
effervescence is created by combining an alkaline material with an
acidic material, either or both of which may be encapsulated. In
some embodiments, an alkaline material may include alkali metal
carbonates, alkali metal bicarbonates, alkaline earth metal
carbonates, alkaline earth metal bicarbonates and mixtures thereof.
In some embodiments, an acidic material may include acetic acid,
adipic acid, ascorbic acid, butyric acid, citric acid, formic acid,
fumaric acid, glyconic acid, lactic acid, phosphoric acid, malic
acid, oxalic acid, succinic acid, tartaric acid and combinations
thereof. Examples of "tingling" type sensates can be found in U.S.
Pat. No. 6,780,443, the entire contents of which are incorporated
herein by reference for all purposes. Tingling agents are described
in U.S. Pat. No. 6,780,443 to Nakatsu et al., U.S. Pat. No.
5,407,665 to McLaughlin et al., U.S. Pat. No. 6,159,509 to Johnson
et al. and U.S. Pat. No. 5,545,424 to Nakatsu et al., each of which
is incorporated by reference herein in its entirety.
[0209] Oral care agents that may be used include those actives
known to the skilled artisan, such as, but not limited to,
surfactants, breath freshening agents, anti-microbial agents,
antibacterial agents, anti-calculus agents, anti-plaque agents,
oral malodor control agents, fluoride compounds, quaternary
ammonium compounds, remineralization agents and combinations
thereof.
[0210] Suitable surfactants include, but are not limited to, salts
of fatty acids selected from the group consisting of
C.sub.8-C.sub.24, palmitoleic acid, oleic acid, eleosteric acid,
butyric acid, caproic acid, caprylic acid, capric acid, lauric
acid, myristic acid, palmitic acid, stearic acid, ricinoleic acid,
arachidic acid, behenic acid, lignoceric acid, cerotic acid,
sulfated butyl oleate, medium and long chain fatty acid esters,
sodium oleate, salts of fumaric acid, potassium glomate, organic
acid esters of mono- and diglycerides, stearyl monoglyceridyl
citrate, succistearin, dioctyl sodium sulfosuccinate, glycerol
tristearate, lecithin, hydroxylated lecithin, sodium lauryl
sulfate, acetylated monoglycerides, succinylated monoglycerides,
monoglyceride citrate, ethoxylated mono- and diglycerides, sorbitan
monostearate, calcium stearyl-2-lactylate, sodium stearyl
lactylate, lactylated fatty acid esters of glycerol and propylene
glycerol, glycerol-lactoesters of C.sub.8-C.sub.24 fatty acids,
polyglycerol esters of C.sub.8-C.sub.24 fatty acids, propylene
glycol alginate, sucrose C.sub.8-C.sub.24 fatty acid esters,
diacetyl tartaric and citric acid esters of mono- and diglycerides,
triacetin, sarcosinate surfactants, isethionate surfactants,
tautate surfactants, pluronics, polyethylene oxide condensates of
alkyl phenols, products derived from the condensation of ethylene
oxide with the reaction product of propylene oxide and ethylene
diamine, ethylene oxide condensates of aliphatic alcohols, long
chain tertiary amine oxides, long chain tertiary phosphine oxides,
long chain dialkyl sulfoxides, and combinations thereof.
[0211] Suitable antibacterial agents include, but are not limited
to, chlorhexidine, alexidine, quaternary ammonium salts,
benzethonium chloride, cetyl pyridinium chloride,
2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan) and
combinations thereof.
[0212] Suitable fluoride compounds include, but are not limited to,
sodium fluoride, sodium monofluorophosphate, stannous fluoride and
combinations thereof.
[0213] Suitable anti-calculus agents include, but are not limited
to, pyrophosphates, triphosphates, polyphosphates,
polyphosphonates, dialkali metal pyrophosphate salt, tetra alkali
polyphosphate salt, tetrasodium pyrophosphate, tetrapotassium
pyrophosphate, sodium tripolyphosphate and combinations
thereof.
[0214] Suitable anti-microbial agents include, but are not limited
to, cetylpyridinium chloride, zinc compounds, copper compounds and
combinations thereof.
[0215] Suitable remineralization agents include, but are not
limited to casein phosphopeptide-amorphous calcium phosphate,
casein phosphoprotein-calcium phosphate complex, casein
phosphopeptide-stabilized calcium phosphate, and combinations
thereof.
[0216] Other oral care actives known to those skilled in the art
are considered well within the scope of the present invention.
[0217] Pharmaceutical actives include drugs or medicaments, breath
fresheners, vitamins and other dietary supplements, minerals,
caffeine, nicotine, fruit juices, and the like, and mixtures
thereof. Examples of useful drugs include ace-inhibitors,
antianginal drugs, anti-arrhythmias, anti-asthmatics,
anti-cholesterolemics, analgesics, anesthetics, anti-convulsants,
anti-depressants, anti-diabetic agents, anti-diarrhea preparations,
antidotes, anti-histamines, anti-hypertensive drugs,
anti-inflammatory agents, anti-lipid agents, anti-manics,
anti-nauseants, anti-stroke agents, anti-thyroid preparations,
anti-tumor drugs, anti-viral agents, acne drugs, alkaloids, amino
acid preparations, anti-tussives, anti-uricemic drugs, anti-viral
drugs, anabolic preparations, systemic and non-systemic
anti-infective agents, anti-neoplastics, anti-parkinsonian agents,
anti-rheumatic agents, appetite stimulants, biological response
modifiers, blood modifiers, bone metabolism regulators,
cardiovascular agents, central nervous system stimulates,
cholinesterase inhibitors, contraceptives, decongestants, dietary
supplements, dopamine receptor agonists, endometriosis management
agents, enzymes, erectile dysfunction therapies such as sildenafil
citrate, which is currently marketed as Viagra.RTM., fertility
agents, gastrointestinal agents, homeopathic remedies, hormones,
hypercalcemia and hypocalcemia management agents, immunomodulators,
immunosuppressives, migraine preparations, motion sickness
treatments, muscle relaxants, obesity management agents,
osteoporosis preparations, oxytocics, parasympatholytics,
parasympathomimetics, prostaglandins, psychotherapeutic agents,
respiratory agents, sedatives, smoking cessation aids such as
bromocryptine or nicotine, sympatholytics, tremor preparations,
urinary tract agents, vasodilators, laxatives, antacids, ion
exchange resins, anti-pyretics, appetite suppressants,
expectorants, anti-anxiety agents, anti-ulcer agents,
anti-inflammatory substances, coronary dilators, cerebral dilators,
peripheral vasodilators, psycho-tropics, stimulants,
anti-hypertensive drugs, vasoconstrictors, migraine treatments,
antibiotics, tranquilizers, anti-psychotics, anti-tumor drugs,
anti-coagulants, anti-thrombotic drugs, hypnotics, anti-emetics,
anti-nauseants, anti-convulsants, neuromuscular drugs, hyper- and
hypo-glycemic agents, thyroid and anti-thyroid preparations,
diuretics, anti-spasmodics, terine relaxants, anti-obesity drugs,
erythropoietic drugs, anti-asthmatics, cough suppressants,
mucolytics, DNA and genetic modifying drugs, and combinations
thereof.
[0218] In some embodiments, a mixture of at least one active
substance and at least one taste potentiator is encapsulated,
rather than encapsulating the taste potentiator or the active
substance alone. Similar to above, the encapsulant may be selected
to delay or increase the rate of release of the mixture of
components. Any of the encapsulants described above may be
employed.
[0219] For example, in some embodiments, the active substance(s)
may be at least one intense sweetener. The intense sweetener(s) may
be mixed with at least one taste potentiator, which is selected to
increase the sweet taste of the intense sweetener(s). This mixture
of components may then be encapsulated. Examples of suitable
intense sweeteners include, but are not limited to, neotame,
aspartame, Acesulfame-K, sucralose, saccharin and combinations
thereof.
[0220] In embodiments including an encapsulated mixture of
active(s) and potentiator(s), the active substance(s) may be
present in amounts of about 1% to about 95% by weight of the
composition, more specifically about 5% to about 30% by weight. The
taste potentiator(s) may be present in amounts of about 0.01% to
about 12% by weight of the composition, more specifically about
0.1% to about 5% by weight. The encapsulant may be present in
amounts of about 1% to about 95% by weight of the composition, more
specifically about 10% to about 60% by weight.
[0221] As mentioned above, some embodiments may include a mixture
of at least one encapsulated taste potentiator and at least one
taste potentiator in its free form. The encapsulated and
unencapsulated taste potentiators may be the same or different. The
encapsulated taste potentiator(s) may be encapsulated by any of the
materials described above. The mixture of encapsulated and
unencapsulated taste potentiators may be combined with one or more
active substances to provide a potentiator composition.
[0222] Some other embodiments provide compositions that modulate
the activity of taste receptor cells in a mammal. Such compositions
may include at least one active substance and at least one taste
potentiator, as described above. These components may be
encapsulated or unencapsulated, also as described above. The taste
potentiator(s) may modulate the activity of taste receptor cells
upon consumption of the composition. More specifically, taste is
perceived through sensory cells located in the taste buds.
Different signaling mechanisms sense the primary tastes of salty,
sour, sweet, bitter and umami. Eventually a nerve impulse is
triggered in the brain that is sensed as one of these primary
tastes.
[0223] Taste potentiators function by modulating the activity of
taste receptor cells at some point in this taste signaling pathway.
For instance, in some cases, taste potentiators may bind to taste
receptors, such as, for example, sweet taste receptors, which
thereby enhances the perception of the sweet taste. In other
embodiments, for example, taste potentiators may block taste
receptors, such as, for example bitter receptors, which suppresses
the perception of a bitter taste and thereby enhances the
perception of a sweet taste. Taste potentiator(s), therefore,
modulate the activity of taste receptor cells in mammals, which
thereby enhances the perception of a given taste. This activity may
enhance the perception of an active substance contained in the
composition when consumed in conjunction with a taste
potentiator.
Edible Orally Delivered Products
[0224] In some embodiments, the potentiator compositions may reside
in an orally delivered product including at least one active
substance and at least one taste potentiator.
[0225] The orally delivered product may be a foodstuff,
pharmaceutical or personal care product. Preferred foodstuffs
include confectionery, especially chocolates, hard boilings and
other sugar-based candies, jellies, soft candies, edible films,
lozenges, pressed tablets, cereal bars, chewing gum, and the like.
Pharmaceuticals may be delivered in the form of a tablet, capsule,
solution, tincture, linctus or syrup. Confectionery and solid
pharmaceutical delivery forms optionally can be coated. Exemplary
personal products include toothpaste, mouth spray, and mouth
wash.
[0226] In some embodiments, the orally delivered product may be a
frozen or refrigerated/perishable product. Such frozen or
refrigerated foodstuffs may include, but are not limited to, frozen
desserts, frozen confections, yogurts, puddings, frozen baked goods
and whipped toppings.
[0227] In still other embodiments, sweetened orally delivered
products may include jams, jellies, peanut butter, baked goods,
syrups, toppings, and sweet and salty snacks, such as sweetened
roasted nuts, kettle corn, barbeque potato snacks, and the
like.
[0228] In some embodiments, the orally delivered product may
include a confectionery base or gum base and any of the potentiator
compositions described herein. In some embodiments, some or all of
the active and/or the taste potentiator may be employed in a free
form (e.g., unencapsulated). Alternatively, the product may include
some or all of the active and/or the taste potentiator in an
encapsulated form. As a further alternative, the product may
include some of the active and/or the taste potentiator in a free
form and some of the active and/or the taste potentiator in an
encapsulated form. In some embodiments, the product may include two
or more potentiator compositions.
[0229] In some embodiments, the potentiator composition used in the
orally delivered product may be a sweetener potentiator composition
including 3-HB and/or 2,4-DHB. As mentioned above, 3-HB and 2,4-DHB
act synergistically with one another to enhance the sweetness of
orally delivered products into which the potentiators are
incorporated.
[0230] For beverages and confectionery products, the concentration
of 3-HB, as calculated in the form of the free acid, generally may
be up to 1500 ppm in the orally delivered product, more
specifically in the range from 100 to 1500 ppm, even more
specifically in the range from 200 to 1000 ppm, yet more
specifically in the range from 300 to 800 ppm and most specifically
in the range from 400 to 600 ppm.
[0231] For beverages and confectionery products, the concentration
of 2,4-DHB, as calculated in the form of the free acid, generally
may be up to 1500 ppm in the product, more specifically in the
range from 100 to 1500 ppm, even more specifically in the range
from 200 to 1000 ppm, yet more specifically in the range from 300
to 800 ppm and most specifically in the range from 400 to 600
ppm.
[0232] In general, the combined concentration of 3-HB and 2,4-DHB
may be no more than 1500 ppm in beverages and confectioneries.
[0233] For chewing gums, the concentration of 3-HB and/or 2,4-DHB,
as calculated in the form of the free acid, generally may be up to
5000 ppm in the product, more specifically in the range from 100 to
5000 ppm, even more specifically in the range from 1000 to 5000
ppm, yet more specifically in the range from 2000 to 5000 ppm and
most specifically in the range from 3000 to 5000 ppm.
[0234] Of course, the required concentrations will depend upon the
nature of the orally delivered product to be sweetened, the level
of sweetness required, the nature of the sweetener(s) in the
product and the degree of enhancement required.
Confectionery Compositions
[0235] When the orally delivery product is a confectionery
composition, the product may be a comestible selected from forms
such as, but not limited to, hard candy, soft candy, center-fill
candy, cotton candy, pressed tablets, edible film, lozenges, and
the like.
[0236] Confectionery compositions may include a confectionery base
and any of the potentiator compositions described above, which may
include at least one active substance and at least one taste
potentiator. The confectionery compositions also may include a
variety of optional additives, as provided in more detail below.
Upon consumption, the composition containing the active(s) and the
taste potentiator(s) releases from the confection and provides an
enhanced perception of the active(s) contained therein.
[0237] For example, in some embodiments, the active substance may
be at least one sweetener, such as, a sugar sweetener, sugarless
bulk sweetener, intense sweetener or any combination thereof. In
general, the active substance(s) may be present in amounts of about
0.0001% to about 75% by weight of the confectionery composition. In
some embodiments, which include actives other than intense
sweeteners, the active substance(s) may be present in amounts of
about 25% to about 75% by weight of the confectionery composition.
The taste potentiator(s) may be present in amounts of about 0.01%
to about 10% by weight of the confectionery composition.
[0238] Some embodiments are directed to a comestible in the form of
a lozenge or candy, also commonly referred to as confectioneries.
Such confectionery compositions may include a confectionery base
including bulk sweeteners such as sugars and sugarless bulk
sweeteners, or the like, or mixtures thereof. Bulk sweeteners
generally are present in amounts of about 0.05% to about 99% by
weight of the composition.
[0239] A variety of traditional ingredients also may be included in
the confectioneries in effective amounts such as coloring agents,
antioxidants, preservatives, sweeteners, and the like. Coloring
agents may be used in amounts effective to produce the desired
color. The coloring agents may include pigments which may be
incorporated in amounts up to about 6%, by weight of the
composition. For example, titanium dioxide may be incorporated in
amounts up to about 2%, and preferably less than about 1%, by
weight of the composition. The colorants may also include natural
food colors and dyes suitable for food, drug and cosmetic
applications. These colorants are known as F.D. & C. dyes and
lakes. The materials acceptable for the foregoing uses are
preferably water-soluble. Illustrative nonlimiting examples include
the indigoid dye known as F.D. & C. Blue No. 2, which is the
disodium salt of 5,5-indigotindisulfonic acid. Similarly, the dye
known as F.D. & C. Green No. 1 comprises a triphenylmethane dye
and is the monosodium salt of 4-[4-(N-ethyl-p-sulfoniumbenzylamino)
diphenylmethylene]-[1-(N-ethyl-N-p-sulfoniumbenzyl)-delta-2,5-cyclohexadi-
eneimine]. A full recitation of all F.D. & C. colorants and
their corresponding chemical structures may be found in the
Kirk-Othmer Encyclopedia of Chemical Technology, 3rd Edition, in
volume 5 at pages 857-884, which text is incorporated herein by
reference.
[0240] Lubricants also may be added in some embodiments to improve
the smoothness of the comestible, such as, for example hard candy
embodiments. Smoothness also is a characteristic that leads to an
increased perception of hydration upon consumption. Suitable
lubricants include, but are not limited to, fats, oils, aloe vera,
pectin and combinations thereof.
[0241] Similarly, in some embodiments, the comestible may have
smooth edges. In such embodiments, the comestible may have any
shape, such as square, circular or diamond-shaped, however, the
edges are rounded to provide a smooth comestible. Another manner of
lending smoothness to the comestibles is to deposit the comestible
composition into moulds during the manufacturing process.
Accordingly, in some embodiments, the comestible is deposited, as
described in more detail below.
[0242] In some embodiments, the confectionery composition may
further include a sweetener selected from Lo han guo, stevia,
monatin and combinations thereof.
[0243] Other conventional additives known to one having ordinary
skill in the art also may be used in the confectionery
compositions.
[0244] In some embodiments, confectionery compositions may be
produced by batch processes. Such confections may be prepared using
conventional apparatus such as fire cookers, cooking extruders,
and/or vacuum cookers. In some embodiments, the bulk sweetener
(sugar or sugar free) and a solvent (e.g., water), are combined in
a mixing vessel to form a slurry. The slurry is heated to about
70.degree. C. to 120.degree. C. to dissolve any sweetener crystals
or particles and to form an aqueous solution. Once dissolved, heat
and vacuum are applied to cook the batch and boil off water until a
residual moisture of less than about 4% is achieved. The batch
changes from a crystalline to an amorphous, or glassy, phase. The
potentiator composition then may be admixed in the batch by
mechanical mixing operations, along with any other optional
additives, such as coloring agents, flavorants, and the like. The
batch is then cooled to about 50.degree. C. to 10.degree. C. to
attain a semi-solid or plastic-like consistency.
[0245] The optimum mixing required to uniformly mix the actives,
potentiators, and other additives during manufacturing of hard
confectionery is determined by the time needed to obtain a uniform
distribution of the materials. Normally, mixing times of from four
to ten minutes have been found to be acceptable. Once the candy
mass has been properly tempered, it may be cut into workable
regions or formed into desired shapes having the correct weight and
dimensions. A variety of forming techniques may be utilized
depending upon the shape and size of the final product desired.
Once the desired shapes are formed, cool air is applied to allow
the comestibles to set uniformly, after which they are wrapped and
packaged.
[0246] Alternatively, various continuous cooking processes
utilizing thin film evaporators and injection ports for
incorporation of ingredients including the potentiator compositions
are known in the art and may be used as well.
[0247] The apparatus useful in accordance with some embodiments
comprise cooking and mixing apparatus well known in the
confectionery manufacturing arts, and selection of specific
apparatus will be apparent to one skilled in the art.
[0248] Additionally, in some embodiments, various confectionery
configurations with multiple regions may be employed. These
configurations may include, but are not limited to, liquid
center-fill, powder center-fill, hard coated, soft coated,
laminated, layered and enrobed. In some embodiments, the
potentiator composition may be included in one region or in
multiple regions of the product.
Soft Confectionery Compositions
[0249] In some embodiments, the orally delivered product may be in
the form of various soft confectionery formats. Soft confectionery
formats may include, but are not limited to, nougat, caramel,
taffy, gummies and jellies.
[0250] Soft confectionery compositions may include a confectionery
base and any of the potentiator compositions described above, which
may include at least one active substance and at least one taste
potentiator. The soft confectionery compositions also may include a
variety of optional additives, such as any of the additives set
forth above in the section describing confectionery compositions.
Upon consumption, the composition containing the active(s) and the
taste potentiator(s) releases from the soft confection and provides
an enhanced perception of the active(s) contained therein.
[0251] For example, in some embodiments, the active substance may
be at least one sweetener, such as, a sugar sweetener, sugarless
bulk sweetener, intense sweetener or any combination thereof. In
general, the active substance(s) may be present in amounts of about
0.0001% to about 75% by weight of the soft confectionery
composition. In some embodiments, which include actives other than
intense sweeteners, the active substance(s) may be present in
amounts of about 25% to about 75% by weight of the soft
confectionery composition. The taste potentiator(s) may be present
in amounts of about 0.01% to about 10% by weight of the soft
confectionery composition.
[0252] Some soft confectionery compositions include nougat
compositions, which may include two principal components, a
high-boiled candy and a frappe. By way of example, egg albumen or
substitute thereof is combined with water and whisked to form a
light foam. Sugar and glucose are added to water and boiled
typically at temperatures of from about 130.degree. C. to
140.degree. C. and the resulting boiled product is poured into a
mixing machine and beaten until creamy. The beaten albumen and
flavoring agent are combined with the creamy product and the
combination is thereafter thoroughly mixed.
[0253] In some embodiments, a caramel composition may include sugar
(or sugar substitute), corn syrup (or polyol syrup), partially
hydrogenated fat, milk solids, water, butter, flavors, emulsifiers,
and salt. To prepare the caramel, the sugar/sugar substitute, corn
syrup/polyol syrup, and water may be mixed together and dissolved
over heat. Then, the milk solids may be mixed in to the mass to
form a homogeneous mixture. Next, the minor ingredients may be
mixed in with low heat. The heat then may be increased to boiling.
Once sufficient water is removed and color/flavor developed, the
mass may be cooled somewhat and temperature sensitive ingredients
(including some potentiators) may be mixed in prior to discharging
and forming/shaping/wrapping the finished product.
[0254] In some embodiments, a taffy composition may include sugar
(or sugar substitute), corn syrup (or polyol syrup), partially
hydrogenated fat, water, flavors, emulsifiers, and salt. The
process for preparing taffy can be similar to that for caramel and,
optionally, the final taffy mass may be pulled to develop its
desired texture.
[0255] In some embodiments, a gummi composition may include sugar
(or sugar substitute), corn syrup (or polyol syrup), gelatin (or
suitable hydrocolloid), flavor, color, and optionally acid. The
gummi may be prepared by hydrating the gelatin or suitable
hydrocolloid, heating the sugar/corn syrup (sugar substitute/polyol
syrup) and combining the two components with heat. Once the
combined mixture reaches its final temperature or suitable sugar
solids level, components such as flavor, color, and the like may be
incorporated into the mixture and then poured into molds prior to
cooling, wrapping, and finishing. Various surface treatments such
as applications of wax or fat can be applied to decrease
sticking.
[0256] In some embodiments, a jelly composition may include a
starch-based jelly or a pectin-based jelly. As with gummies, jelly
products may be produced by hydrating the hydrocolloid and
combining the hydrated mixture with a cooked syrup component. The
mixture then may be cooked to a final moisture content and minor
components may be incorporated. As with gummies, jelly candies may
be poured into molds such as starch molds. As with gummies, surface
treatments, such as fats or waxes, may be applied. Additionally,
jelly candies may have dry surface treatments, such as applications
of sanding sugar, acid, non-pareils, and the like.
[0257] Additionally, in some embodiments, various soft
confectionery configurations with multiple regions may be employed.
These configurations may include, but are not limited to, liquid
center-fill, powder center-fill, hard coated, soft coated,
laminated, layered and enrobed. In some embodiments, the
potentiator composition may be included in one region or in
multiple regions of the product.
Chewing Gum Compositions
[0258] Some embodiments provide chewing gum compositions for
delivery of the potentiator compositions described above. Such
chewing gum compositions may include a gum base and any of the
potentiator compositions described above, which may include at
least one active substance and at least one taste potentiator. The
chewing gum compositions also may include a variety of optional
additives, as provided in more detail below. Upon consumption, the
composition containing the active(s) and the taste potentiator(s)
releases from the chewing gum and provides an enhanced perception
of the active(s) contained therein.
[0259] As described in detail above, in some embodiments, the
potentiator composition generally includes at least one active
substance and at least one taste potentiator. In some embodiments,
the taste potentiator(s) and/or active(s) may be encapsulated, as
described above, or a mixture of the active(s) and taste
potentiator(s) may be encapsulated. These components may be
selected from any of those described above. For example, in some
embodiments, the active substance may be at least one sweetener,
such as, a sugar sweetener, sugarless bulk sweetener, intense
sweetener or any combination thereof. In general, the active
substance(s) may be present in amounts of about 0.0001% to about
75% by weight of the chewing gum composition. In some embodiments,
which include actives other than intense sweeteners, the active
substance(s) may be present in amounts of about 25% to about 75% by
weight of the chewing gum composition. The taste potentiator(s) may
be present in amounts of about 0.01% to about 10% by weight of the
chewing gum composition.
[0260] In some embodiments, the chewing gum composition may include
multiple taste potentiators. The taste potentiators may be
encapsulated or unencapsulated and may be the same or different. In
some embodiments, the multiple taste potentiators may be different.
Some chewing gum compositions, for instance, may include one or
more taste potentiators that are encapsulated in combination with
one or more different taste potentiators that are unencapsulated.
In some embodiments, two different encapsulated taste potentiators
may be used in a chewing gum composition. Alternatively, in some
other embodiments, the chewing gum composition may include a
combination of the same taste potentiator in its encapsulated and
free forms.
[0261] The chewing gum composition also may include a gum base. The
gum base may include any component known in the chewing gum art.
Such components may be water soluble, water-insoluble or a
combination thereof. For example, the gum base may include
elastomers, bulking agents, waxes, elastomer solvents, emulsifiers,
plasticizers, fillers and mixtures thereof.
[0262] The elastomers (rubbers) employed in the gum base will vary
greatly depending upon various factors such as the type of gum base
desired, the consistency of gum composition desired and the other
components used in the composition to make the final chewing gum
product. The elastomer may be any water-insoluble polymer known in
the art, and includes those gum polymers utilized for chewing gums
and bubble gums. Illustrative examples of suitable polymers in gum
bases include both natural and synthetic elastomers. For example,
those polymers which are suitable in gum base compositions include,
without limitation, natural substances (of vegetable origin) such
as chicle, natural rubber, crown gum, nispero, rosidinha, jelutong,
perillo, niger gutta, tunu, balata, guttapercha, lechi capsi,
sorva, gutta kay, and the like, and mixtures thereof. Examples of
synthetic elastomers include, without limitation, styrene-butadiene
copolymers (SBR), polyisobutylene, isobutylene-isoprene copolymers,
polyethylene, polyvinyl acetate and the like, and mixtures
thereof.
[0263] The amount of elastomer employed in the gum base may vary
depending upon various factors such as the type of gum base used,
the consistency of the gum composition desired and the other
components used in the composition to make the final chewing gum
product. In general, the elastomer will be present in the gum base
in an amount from about 10% to about 60% by weight, desirably from
about 35% to about 40% by weight.
[0264] In some embodiments, the gum base may include wax. It
softens the polymeric elastomer mixture and improves the elasticity
of the gum base. When present, the waxes employed will have a
melting point below about 60.degree. C., and preferably between
about 45.degree. C. and about 55.degree. C. The low melting wax may
be a paraffin wax. The wax may be present in the gum base in an
amount from about 6% to about 10%, and preferably from about 7% to
about 9.5%, by weight of the gum base.
[0265] In addition to the low melting point waxes, waxes having a
higher melting point may be used in the gum base in amounts up to
about 5%, by weight of the gum base. Such high melting waxes
include beeswax, vegetable wax, candelilla wax, carnuba wax, most
petroleum waxes, and the like, and mixtures thereof.
[0266] In addition to the components set out above, the gum base
may include a variety of other ingredients, such as components
selected from elastomer solvents, emulsifiers, plasticizers,
fillers, and mixtures thereof.
[0267] The gum base may contain elastomer solvents to aid in
softening the elastomer component. Such elastomer solvents may
include those elastomer solvents known in the art, for example,
terpinene resins such as polymers of alpha-pinene or beta-pinene,
methyl, glycerol and pentaerythritol esters of rosins and modified
rosins and gums such as hydrogenated, dimerized and polymerized
rosins, and mixtures thereof. Examples of elastomer solvents
suitable for use herein may include the pentaerythritol ester of
partially hydrogenated wood and gum rosin, the pentaerythritol
ester of wood and gum rosin, the glycerol ester of wood rosin, the
glycerol ester of partially dimerized wood and gum rosin, the
glycerol ester of polymerized wood and gum rosin, the glycerol
ester of tall oil rosin, the glycerol ester of wood and gum rosin
and the partially hydrogenated wood and gum rosin and the partially
hydrogenated methyl ester of wood and rosin, and the like, and
mixtures thereof. The elastomer solvent may be employed in the gum
base in amounts from about 2% to about 15%, and preferably from
about 7% to about 11%, by weight of the gum base.
[0268] The gum base may also include emulsifiers which aid in
dispersing the immiscible components into a single stable system.
The emulsifiers useful in this invention include glyceryl
monostearate, lecithin, fatty acid monoglycerides, diglycerides,
propylene glycol monostearate, and the like, and mixtures thereof.
The emulsifier may be employed in amounts from about 2% to about
15%, and more specifically, from about 7% to about 11%, by weight
of the gum base.
[0269] The gum base may also include plasticizers or softeners to
provide a variety of desirable textures and consistency properties.
Because of the low molecular weight of these ingredients, the
plasticizers and softeners are able to penetrate the fundamental
structure of the gum base making it plastic and less viscous.
Useful plasticizers and softeners include lanolin, palmitic acid,
oleic acid, stearic acid, sodium stearate, potassium stearate,
glyceryl triacetate, glyceryl lecithin, glyceryl monostearate,
propylene glycol monostearate, acetylated monoglyceride, glycerine,
and the like, and mixtures thereof. Waxes, for example, natural and
synthetic waxes, hydrogenated vegetable oils, petroleum waxes such
as polyurethane waxes, polyethylene waxes, paraffin waxes,
microcrystalline waxes, fatty waxes, sorbitan monostearate, tallow,
propylene glycol, mixtures thereof, and the like, may also be
incorporated into the gum base. The plasticizers and softeners are
generally employed in the gum base in amounts up to about 20% by
weight of the gum base, and more specifically in amounts from about
9% to about 17%, by weight of the gum base.
[0270] Plasticizers also include hydrogenated vegetable oils, such
as soybean oil and cottonseed oils, which may be employed alone or
in combination. These plasticizers provide the gum base with good
texture and soft chew characteristics. These plasticizers and
softeners are generally employed in amounts from about 5% to about
14%, and more specifically in amounts from about 5% to about 13.5%,
by weight of the gum base.
[0271] Anhydrous glycerin may also be employed as a softening
agent, such as the commercially available United States
Pharmacopeia (USP) grade. Glycerin is a syrupy liquid with a sweet
warm taste and has a sweetness of about 60% of that of cane sugar.
Because glycerin is hygroscopic, the anhydrous glycerin may be
maintained under anhydrous conditions throughout the preparation of
the chewing gum composition.
[0272] In some embodiments, the gum base may also include effective
amounts of bulking agents such as mineral adjuvants which may serve
as fillers and textural agents. Useful mineral adjuvants include
calcium carbonate, magnesium carbonate, alumina, aluminum
hydroxide, aluminum silicate, talc, tricalcium phosphate, dicalcium
phosphate, calcium sulfate and the like, and mixtures thereof.
These fillers or adjuvants may be used in the gum base compositions
in various amounts. Preferably the amount of filler, when used,
will be present in an amount from about 15% to about 40%, and
desirably from about 20% to about 30%, by weight of the gum
base.
[0273] A variety of traditional ingredients may be optionally
included in the gum base in effective amounts such as flavor agents
and coloring agents, antioxidants, preservatives, and the like. For
example, titanium dioxide and other dyes suitable for food, drug
and cosmetic applications, known as F. D. & C. dyes, may be
utilized. An anti-oxidant such as butylated hydroxytoluene (BHT),
butylated hydroxyanisole (BHA), propyl gallate, vitamin E and
mixtures thereof, may also be included. Other conventional chewing
gum additives known to one having ordinary skill in the chewing gum
art may also be used in the gum base.
[0274] The chewing gum compositions may include amounts of
conventional additives selected from the group consisting of
sweetening agents, plasticizers, softeners, emulsifiers, waxes,
fillers, bulking agents (carriers, extenders, bulk sweeteners),
mineral adjuvants, flavor agents and coloring agents, antioxidants,
acidulants, thickeners, medicaments, oral care actives, such as
remineralization agents, antimicrobials and tooth whitening agents,
as described in assignee's co-pending U.S. patent application Ser.
No. 10/901,511, filed on Jul. 29, 2004 and entitled "Tooth
Whitening Compositions and Delivery Systems Therefor," which is
incorporated herein by reference in its entirety, and the like, and
mixtures thereof. Some of these additives may serve more than one
purpose. For example, in sugarless gum compositions, a sweetener,
such as maltitol or other sugar alcohol, may also function as a
bulking agent.
[0275] Bulk sweeteners include sugars, sugarless bulk sweeteners,
or the like, or mixtures thereof. Bulk sweeteners generally are
present in amounts of about 5% to about 99% by weight of the
chewing gum composition. Suitable sugar sweeteners and sugarless
bulk sweeteners, as well as intense sweeteners are provided above
in the description of the potentiator compositions.
[0276] In general, an effective amount of intense sweetener may be
utilized to provide the level of sweetness desired, and this amount
may vary with the sweetener selected. The intense sweetener may be
present in amounts from about 0.001% to about 3%, by weight of the
chewing gum composition, depending upon the sweetener or
combination of sweeteners used. The exact range of amounts for each
type of sweetener may be selected by those skilled in the art.
[0277] In some embodiments, the chewing gum composition may include
a sweetener selected from Lo han guo, stevia, monatin and
combinations thereof.
[0278] Any of the flavor agents discussed above as being suitable
for use in the potentiator compositions also may be used in the
chewing gum compositions. In chewing gum compositions, flavor
agents generally may be present in amounts from about 0.02% to
about 5%, and more specifically from about 0.1% to about 4%, and
even more specifically, from about 0.8% to about 3%, by weight of
the composition.
[0279] Coloring agents may be used in amounts effective to produce
the desired color. The coloring agents may include pigments which
may be incorporated in amounts up to about 6%, by weight of the
composition. For example, titanium dioxide may be incorporated in
amounts up to about 2%, and preferably less than about 1%, by
weight of the composition. The colorants may also include natural
food colors and dyes suitable for food, drug and cosmetic
applications. Suitable coloring agents are set forth above in the
description of confectionery compositions.
[0280] The plasticizers, softening agents, mineral adjuvants, waxes
and antioxidants discussed above, as being suitable for use in the
gum base, may also be used in the chewing gum composition. Examples
of other conventional additives which may be used include
emulsifiers, such as lecithin and glyceryl monostearate,
thickeners, used alone or in combination with other softeners, such
as methyl cellulose, alginates, carrageenan, xanthan gum, gelatin,
carob, tragacanth, locust bean, and carboxy methyl cellulose,
acidulants such as malic acid, adipic acid, citric acid, tartaric
acid, fumaric acid, and mixtures thereof, and fillers, such as
those discussed above under the category of mineral adjuvants.
[0281] Other conventional gum additives known to one having
ordinary skill in the chewing gum art also may be used in the
chewing gum compositions.
[0282] In some embodiments, the potentiator composition included in
the chewing gum composition may include at least one active
substance having a first solubility and at least one taste
potentiator having a second solubility. The first and second
solubilities may be substantially similar or different and may be
selected to provide a controlled-release profile to the chewing gum
composition. In particular, the selected solubilities may provide
one of the following release profiles: simultaneous release,
sequential release or partially overlapping release.
[0283] Some embodiments extend to methods of preparing a chewing
gum product. The products may be prepared using standard techniques
and equipment known to those skilled in the art. The apparatus
useful in accordance with the embodiments described herein includes
mixing and heating apparatus well known in the chewing gum
manufacturing arts, and therefore the selection of the specific
apparatus will be apparent to the artisan. For general chewing gum
preparation processes see U.S. Pat. Nos. 4,271,197 to Hopkins et
al, 4,352,822 to Cherukuri et al and 4,497,832 to Cherukuri et al,
each of which is incorporated herein by reference in its
entirety.
[0284] More specifically, in accordance with some embodiments, at
least one encapsulant and at least one taste potentiator may be
mixed to form a dispersion of the components. In particular, the
encapsulant(s) may be melted at elevated temperatures in a high
shear mixer. The potentiator(s) may be added to the molten
encapsulant and mixed under high shear to completely disperse the
components. The components may be mixed at elevated temperatures of
about 50-150.degree. C. The resulting mixture of components may be
cooled. A plurality of encapsulated taste potentiator particles
subsequently may be formed from the mixture. The particles may be
formed to an appropriate size as desired, generally from an average
particle size range of about 50 .mu.m to about 800 .mu.m. This may
be accomplished by any suitable means such as chopping,
pulverizing, milling or grinding the particles.
[0285] Alternatively, the encapsulated particles may be prepared by
spray drying methods. More specifically, the encapsulant(s) may be
dissolved in water. In some embodiments, this solution may be
prepared in an agitated vessel. The taste potentiator(s) then may
be dispersed in the solution. The solution, or suspension, may be
spray dried using a spray dryer fitted with an air atomized nozzle
at elevated temperatures to form the encapsulated particles.
[0286] In other embodiments, the encapsulated particles may be
prepared by any suitable spray coating method as known in the art.
One suitable process is the Wurster process. This process provides
a method for encapsulating individual particulate materials. First,
the particles to be encapsulated are suspended in a fluidizing air
stream, which provides a generally cyclic flow in front of a spray
nozzle. The spray nozzle sprays an atomized flow of the coating
solution, which may include the encapsulant(s) and a suitable
solvent. The atomized coating solution collides with the particles
as they are carried away from the nozzle to provide a particle
coating with the coating solution. The temperature of the
fluidizing air stream, which also serves to suspend the particles
to be coated, may be adjusted to evaporate the solvent shortly
after the coating solution contacts the particles. This serves to
solidify the coating on the particles, resulting in the desired
encapsulated particle.
[0287] In some embodiments, at least one active substance may be
combined in the first step of the process along with the
encapsulant(s) and the taste potentiator(s) to form a dispersion of
all the components. The active substance(s) thereby may be
encapsulated with the taste potentiator(s) to form an encapsulated
mixture of the components.
[0288] Once the encapsulated particles are obtained, they may be
added to a chewing gum composition. Such encapsulated particles
also may be added to confectionery compositions to prepare any of
the confectionery products described above. The chewing gum
composition may be prepared using standard techniques and
equipment, as described above. The encapsulated particles may be
added to the chewing gum composition to enhance the perception of
at least one active substance contained therein, which may be any
of the actives described above. Once the encapsulated particles are
mixed into the chewing gum composition, individual chewing gum
pieces may be formed using standard techniques known in the chewing
gum art. For instance, chewing gum pieces may be prepared in the
form of a slab, pellet, stick, center-fill gum, deposited,
compressed chewing gum or any other suitable format.
[0289] For instance, center-fill chewing gum embodiments may
include a center-fill region, which may be a liquid or powder or
other solid, and a gum region. Some embodiments also may include an
outer gum coating or shell, which typically provides a crunchiness
to the piece when initially chewed. The outer coating or shell may
at least partially surround the gum region. The potentiator
compositions described above may be incorporated into any of the
regions of the center-fill chewing gum, i.e., the center-fill
region, gum region and/or outer coating of the gum. Alternatively,
the taste potentiator(s) may be incorporated into one region while
the active substance(s) is incorporated into a different region of
the center-fill gum. Upon consumption, the taste-potentiator(s) and
active(s) may release from the different regions and combine as the
gum is chewed. Center-fill chewing gums and methods of preparing
same are more fully described in assignee's co-pending U.S. patent
application Ser. No. 10/925,822, filed on Aug. 24, 2004 and
assignee's co-pending U.S. patent application Ser. No. 11/210,954,
filed on Aug. 24, 2005, both entitled "Liquid-Filled Chewing Gum
Composition," the contents both of which are incorporated herein by
reference.
[0290] Some other chewing gum embodiments may be in a compressed
gum format, such as, for example, a pressed tablet gum. Such
embodiments may include a particulate chewing gum base, which may
include a compressible gum base composition and a tableting powder,
and any of the potentiator compositions described above. In such
embodiments, the potentiator composition may be in a powdered form.
Compressed chewing gums are more fully described in assignee's
co-pending U.S. Provisional Application No. 60/734,680, filed on
Nov. 8, 2005, and entitled "Compressible Gum System," the contents
of which are incorporated herein by reference.
[0291] In some embodiments, the chewing gum may have a coating
thereon. Such coated chewing gums are typically referred to as
pellet gums. The outer coating may be hard or crunchy. Any suitable
coating materials known to those skilled in the art may be
employed. Typically, the outer coating may include sorbitol,
maltitol, xylitol, isomalt, erythritol and other crystallizable
polyols; sucrose may also be used. Furthermore the coating may
include several opaque layers, such that the chewing gum
composition is not visible through the coating itself, which can
optionally be covered with a further one or more transparent layers
for aesthetic, textural and protective purposes. The outer coating
may also contain small amounts of water and gum arabic. The coating
can be further coated with wax. The coating may be applied in a
conventional manner by successive applications of a coating
solution, with drying in between each coat. As the coating dries it
usually becomes opaque and is usually white, though other colorants
may be added. A polyol coating can be further coated with wax. The
coating can further include colored flakes or speckles. If the
composition includes a coating, it is possible that one or more
oral care actives can be dispersed throughout the coating. This is
especially preferred if one or more oral care actives is
incompatible in a single phase composition with another of the
actives. Flavors may also be added to yield unique product
characteristics.
[0292] Other materials may be added to the coating to achieve
desired properties. These materials may include without
limitations, cellulosics such as carboxymethyl cellulose, gelatin,
xanthan gum and gum arabic.
[0293] The coating composition may be applied by any method known
in the art including the method described above. The coating
composition may be present in an amount from about 2% to about 60%,
more specifically from about 25% to about 45% by weight of the
total chewing gum piece.
[0294] Similarly, some embodiments extend to methods of preparing a
taste potentiator composition having controlled-release upon
consumption. In accordance therewith, at least one taste
potentiator may first be provided. The taste potentiator(s) may be
mixed with an encapsulant to form a composition having a dispersion
of the components. Once the components are fully dispersed, a
plurality of encapsulated taste potentiator particles may be formed
from the composition, as described above. As a consequence of the
encapsulation, the release rate of the potentiator(s) will be
modified. The material for use as the encapsulant may be selected
to provide either a delayed or increased release rate of the
potentiator(s) upon consumption of the composition.
[0295] The features and advantages of the present invention are
more fully shown by the following examples which are provided for
purposes of illustration, and are not to be construed as limiting
the invention in any way.
EXAMPLES
Example 1
TABLE-US-00002 [0296] TABLE 2 Encapsulated Water-Soluble Taste
Potentiator Component Weight % Polyvinyl acetate (encapsulant)
65.00 Hydrogenated Oil 3.75 Glycerol Monostearate 1.25
Neohesperidindihydrochalcone 30.00
[0297] A potentiator composition is prepared according to the
formulation in Table 2 above.
[0298] The polyvinyl acetate is melted at a temperature of about
90.degree. C. in a high shear mixer. A single or twin screw
extruder, a sigma mixer or a Banbury mixer may be used. The
hydrogenated oil and glycerol monostearate are added to the molten
polyvinyl acetate. Neohesperidindihydrochalcone (NHDC), which is a
water-soluble taste potentiator, is added to the resulting mixture
and mixed under high shear to completely disperse the components.
The resulting filled polymer melt is cooled and ground to a
particle size of less than 420 microns. The encapsulated particles
provide a slow releasing NHDC. The particles are stored in air
tight containers with low humidity below 35.degree. C. until they
are incorporated into consumable products, such as chewing gum.
Example 2
TABLE-US-00003 [0299] TABLE 3 Encapsulated Mixture of Taste
Potentiator and Sweetener Component Weight % Polyvinyl acetate
(encapsulant) 65.00 Hydrogenated Oil 3.75 Glycerol Monostearate
1.25 Aspartame 26.00 Neohesperidindihydrochalcone 4.00
[0300] A potentiator composition is prepared according to the
formulation in Table 3 above.
[0301] The polyvinyl acetate is melted at a temperature of about
90.degree. C. in a high shear mixer. A single or twin screw
extruder, a sigma mixer or a Banbury mixer may be used. The
hydrogenated oil and glycerol monostearate are added to the molten
polyvinyl acetate. NHDC, which is a water-soluble taste
potentiator, and aspartame are added to the resulting mixture and
mixed under high shear to completely disperse the components. The
resulting filled polymer melt is cooled and ground to a particle
size of less than 420 microns. The encapsulated particles provide a
delayed and combined release mixture of NHDC and aspartame. The
particles are stored in air tight containers with low humidity
below 35.degree. C. until they are incorporated into consumable
products, such as chewing gum.
Example 3
TABLE-US-00004 [0302] TABLE 4 Encapsulated Low Water-Soluble Taste
Potentiator Component Weight % Maltitol (encapsulant) 90.00
Sweetener Potentiator 9.00 Glycerol Monostearate 1.00
[0303] A potentiator composition is prepared according to the
formulation in Table 4 above.
[0304] The maltitol is melted at a temperature of about 140.degree.
C. in a high shear mixer. A single or twin screw extruder, a sigma
mixer or a Banbury mixer may be used. The glycerol monostearate is
added to the molten maltitol. The sweetener potentiator, which
exhibits low solubility in water, is added to the resulting mixture
and mixed under high shear to completely disperse the components.
The resulting melt is cooled and ground to a particle size of less
than 590 microns. The encapsulation provides an increased release
rate of the sweetener potentiator upon consumption. The
encapsulated particles are stored in air tight containers with low
humidity below 35.degree. C. until they are incorporated into
consumable products, such as chewing gum.
Example 4
TABLE-US-00005 [0305] TABLE 5 Encapsulated Low Water-Soluble Taste
Potentiator Component Weight % Water 60.00 Maltitol (encapsulant)
34.00 Acetylated monoglyceride 3.00 Sweetener Potentiator 3.00
[0306] A potentiator composition is prepared according to the
formulation in Table 5 above.
[0307] The maltitol and acetylated monoglyceride are dissolved in
water at a temperature of about 70.degree. C. in an agitated
vessel. The sweetener potentiator, which exhibits low solubility in
water, is dispersed in the resulting solution. The solution, or
suspension, is spray dried using a spray dryer fitted with an air
atomized nozzle (stationary or rotary) at about 105.degree. C. to
form encapsulated particles. The encapsulation provides an
increased release rate of the substantially water-insoluble
sweetener potentiator upon consumption. The encapsulated particles
are stored in air tight containers with low humidity below
35.degree. C. until they are incorporated into consumable products,
such as chewing gum.
Example 5
TABLE-US-00006 [0308] TABLE 6 Encapsulated Low Water-Soluble Taste
Potentiator Component Weight % Beta-cyclodextrin (encapsulant)
25.00 Sweetener Potentiator 5.00 Water 50 Ethanol 20.00
[0309] A potentiator composition is prepared according to the
formulation in Table 6 above.
[0310] The beta-cyclodextrin is dissolved in water at a temperature
of about 60.degree. C. The sweetener potentiator, which exhibits
low solubility in water, is dissolved completely in the ethanol and
the resulting solution is added to the beta-cyclodextrin solution
and stirred for about three hours. The resulting solution of
beta-cyclodextrin complex is spray dried using a spray dryer fitted
with an air atomized nozzle (stationary or rotary) at about
60.degree. C. to form encapsulated particles. The encapsulation
provides an increased release rate of the substantially
water-insoluble sweetener potentiator upon consumption. The
encapsulated particles are stored in air tight containers with low
humidity below 35.degree. C. until they are incorporated into
consumable products, such as chewing gum.
Example 6
TABLE-US-00007 [0311] TABLE 7 Chewing Gum Containing Encapsulated
Taste Potentiator Component Weight % Gum base 39.00 Sorbitol 45.58
Mannitol 9.00 Flavor 3.67 Glycerin 1.50 Lecithin 0.20 High
intensity sweeteners.sup.1 1.00 Encapsulated NHDC.sup.2 0.05
.sup.1Aspartame, Acesulfame-K and/or sucralose .sup.2From Example
1
[0312] A chewing gum composition is prepared according to the
formulation in Table 7 above.
[0313] The gum base is melted in a mixer. The remaining components
listed in Table 7 are added to the molten gum base. The melted gum
base and added components are mixed to completely disperse the
components. The resulting chewing gum composition is allowed to
cool. The cooled chewing gum composition is sized and conditioned
for about a week, formed into individual chewing gum pieces
employing conventional techniques and packaged.
Example 7
Sucrose Equivalent Value (SEV)
[0314] One method of measuring the perceived sweetness of a
solution is to match it with a stock sucrose solution of known
concentration. In the present experiments, the compound of interest
is added at a predetermined concentration to a pH 3.2 buffered
solution containing 5% sucrose. A number of expert panel members
then taste the solution and compare it to a battery of stock
sucrose solutions ranging from 3% to 15% at increments of 1%. Each
panel member decides which sucrose solution is equisweet with the
solution containing the compound of interest. The mean value is
then reported as the SEV. Results are reported to 1 decimal
place.
Dose Response Curve for 3-Hydroxybenzoic Acid
[0315] In accordance with this methodology, 3-HB was added to a pH
3.2 buffered solution containing 5% sucrose to produce solutions
containing from 0 to 1000 ppm 3-HB in 100 ppm increments. The SEV
for each solution was plotted on a graph to produce a dose response
curve (FIG. 1), from which it can be seen that 3-HB enhances the
sweetness of the sucrose solution within this range. From FIG. 1 it
is apparent that as the dosage of 3-HB increases so does the
sweetness of the resultant solution. However the effect is
non-linear with each incremental addition having a diminishing
effect. The maximum sweetness attainable would appear to be about
7.9% SEV (based on a 5% sucrose solution).
Example 8
Dose Response Curve for 2,4-Dihydroxybenzoic Acid
[0316] The same methodology as described in Example 7 was repeated
with 2,4-DHB in place of 3-HB, to produce the dose response curve
for 2,4-DHB (FIG. 2). From FIG. 2 it can be seen that 2,4-DHB also
enhances the sweetness of the sucrose solution but there is little
difference between the 400 ppm solution (SEV 6.5%) and the 1000 ppm
solution (SEV 6.7%). The maximum attainable sweetness would appear
to be about 6.7% SEV (based on a 5% sucrose solution).
Example 9
Sucrose Reduction Method
[0317] An alternative method of measuring perceived sweetness is to
determine how much sucrose can be replaced through the use of the
compound of interest without any perceived loss of sweetness. In
the present experiments the control was a pH 3.2 buffered solution
containing 10% sucrose. The compound of interest is added at a
predetermined concentration to a number of sucrose solutions
containing from 5% to 10% sucrose at increments of 0.5%. Each panel
member tastes each of the solutions, compares it to the control
sample and decides which solutions are equisweet. For example, if
the 8% sucrose solution containing the compound of interest is
equisweet with the control, then the sucrose reduction achieved by
the compound of interest is 20%.
Effect of Relative Concentration on Sucrose Reduction for 3-HB,
2,4-DHB mixtures
[0318] A series of sucrose solutions were prepared containing 3-HB
and 2,4-DHB at a combined concentration of 1000 ppm. Each solution
was evaluated using the sucrose reduction method described above to
determine how much sucrose could be replaced without noticeable
loss of sweetness. The results are shown in FIG. 3.
[0319] As shown in FIG. 3, the greatest reduction is observed when
equal quantities of 3-HB and 2,4-DHB are employed. This ratio
results in the very significant sucrose reduction of 45%. This
figure is highly surprising considering that the use of 1000 ppm of
3-HB or 2,4-DHB individually results in a reduction of just 25% and
15% respectively. The other ratios 3-HB:2,4-DHB (8:2, 6:4, 4:6 and
2:8) are also very effective; each combination results in a sucrose
reduction of at least 35%.
Example 10
Effect of Concentration on Sucrose Reduction for 1:1 3-HB:2,4-DHB
Mixtures
[0320] A series of sucrose solutions were prepared containing equal
quantities of 3-HB and 2,4-DHB, at a combined concentration of 200,
400, 600, 800 and 1000 ppm. Each solution was evaluated using the
sucrose reduction method described in Example 9 above to determine
how much sucrose could be replaced without noticeable loss of
sweetness. The results are shown in FIG. 4.
[0321] Increasing the total quantity of 3-HB and 2,4-DHB while
retaining a 1:1 ratio increases the sweetness enhancing effect. As
shown above 500 ppm 3-HB+500 ppm 2,4-DHB results in 45% of the
sucrose being replaced without loss of sweetness. However, the
combination of 3-HB and 2,4-DHB is effective even at very low
concentration. The use of just 200 ppm of each of 3-HB and 2,4-DHB
allows the sucrose content to be reduced by 22%.
Example 11
Sucrose Equivalent Values for Various Benzoic Acid Derivatives and
Combinations Thereof
[0322] 500 ppm of a sweetener potentiator was added to a pH 3.2
buffered solution containing 5% sucrose and the SEV of the
resultant solution determined. The results are shown in Table
8.
TABLE-US-00008 TABLE 8 Sweetness potentiator SEV (%)
2-hydroxybenzoic acid (2-HB) 5.6 3-hydroxybenzoic acid (3-HB) 6.9
4-hydroxybenzoic acid (4-HB) 5.2 2,3-dihydroxybenzoic acid
(2,3-DHB) 6.3 2,4-dihydroxybenzoic acid (2,4-DHB) 6.5
2,5-dihydroxybenzoic acid (2,5-DHB) 5.3 2,6-dihydroxybenzoic acid
(2,6-DHB) 5.3 3,4-dihydroxybenzoic acid (3,4-DHB) 6.4
3,5-dihydroxybenzoic acid (3,5-DHB) 5.3 2,3,4-trihydroxybenzoic
acid (2,3,4-THB) 5.4 2,4,6-trihydroxybenzoic acid (2,4,6-THB) 5.4
3,4,5-tryhydroxybenzoic acid (3,4,5-THB) 5.1
[0323] 500 ppm of the sweetener potentiator then was added to a 5%
sucrose solution containing 500 ppm 3-HB to produce a series of
solutions. The SEV for each solution was determined and the results
are shown in FIG. 5. As shown in FIG. 5, the composition of one
embodiment (hatched) is considerably more effective than any other
combination with an SEV of 8.7%. The use of 500 ppm of 3-HB alone
results in an SEV of 6.9% whereas in all cases but two (2,4-DHB and
3,4-DHB) the addition of a second sweetener potentiator results in
a little change or even a decrease in SEV. This is highly
surprising considering that all of the potentiators are shown to
have SEVs greater than 5%.
[0324] The methodology was repeated to produce a series of
solutions containing 500 ppm 2,4-DHB and 500 ppm of a second
sweetener potentiator. The SEV for each solution was determined and
the results are shown in FIG. 6.
[0325] Again the combination (hatched) of 3-HB and 2,4-DHB results
in by far the greatest sweetness enhancement. It might be expected
that 2-HB or 4-HB could be used in place of 3-HB but these
combinations result in solutions with SEVs of just 6.3% and 6.2%
respectively. The use of 500 ppm 2,4-DHB alone results in a
solution with an SEV of 6.5%. The addition of a second sweetener
potentiator appears to inhibit its effect in most cases and only
the addition of 3-HB has a significant positive effect.
[0326] 500 ppm of 3-HB, 500 ppm of 2,4-DHB and 500 ppm of
3,4-dihydroxybenzoic acid
[0327] (3,4-DHB) were added to a pH 3.2 buffered solution
containing 5% sucrose and the SEV determined. The results are shown
in FIG. 7 together with other combinations of 3-HB, 2,4-DHB and
3,4-DHB for comparison. The solution containing the combination of
3-HB and 2,4-DHB (hatched) has a much higher SEV (8.7%) than the
combination of either 3,4-DHB and 3-HB (7.6%) or the combination of
3,4-DHB and 2,4-DHB (6.8%). The three-way combination of the
embodiment (hatched) is better still with an SEV of 9.8%.
Example 12
Comparison of Different Forms of 2,4-DHB
[0328] pH 3.2 buffered solutions were prepared containing 0%, 3%,
5%, 7% and 9% sucrose. 500 ppm of 2,4-DHB acid, 500 ppm of the
sodium salt of 2,4-DHB and 500 ppm of the potassium salt of 2,4-DHB
were added individually to each of the sucrose solutions. The SEV
for each of the solutions was then determined. The results are
shown in FIG. 8.
[0329] As shown in FIG. 8, the addition of 2,4-DHB enhances the
sweetness of the sucrose solution in every case regardless of the
original sucrose solution or whether the acid, sodium salt or
potassium salt is employed. The results for the acid, sodium salt
and potassium salt are almost identical indicating that the
sweetener potentiator composition may be prepared from the acids
and/or from their comestible salts.
Example 13
Sweetness Enhancing Effect of 3-HB and 2,4-DHB on Non-Sucrose
Sweeteners
[0330] Solutions were prepared at a pH of 3.2 containing a
sufficient quantity of a non-sucrose sweetener so that the
resulting solution had an SEV of about 5%. The SEV of each
sweetener solution was then evaluated after the addition 500 ppm of
3-HB, the addition of 500 ppm of 2,4-DHB and the addition of both
500 ppm 3-HB and 2,4-DHB. The results are shown in FIGS. 9 and
10.
[0331] FIG. 9 shows the results of various intense sweeteners with
3-HB, 2,4-DHB and combinations thereof. As shown in FIG. 9, the
combination of 3-HB and 2,4-DHB with aspartame has a significant
effect on SEV, which is greater than the use of either 3-HB or
2,4-DHB separately. Similarly, the combination of 3-HB and 2,4-DHB
enhances the perceived sweetness of the acesulfame-K,
aspartame/acesulfame-K, sucralose, sucralose/acesulfame-K,
saccharin and neotame solutions. With respect to the saccharin
solution, however, 3-HB enhances the sweetness to a greater degree
alone than in combination with 2,4-DHB.
[0332] FIG. 10 shows the results of various bulk sweeteners with
3-HB, 2,4-DHB and combinations thereof. As seen in FIG. 10, the
combination of 3-HB and 2,4-DHB increases the SEV of the resultant
solution when used with sucrose, fructose, tagatose, maltitol or
glucose to a greater extent than either 3-HB or 2,4-DHB
separately.
Example 14
Sucrose Equivalent Values for Aminobenzoic Acid Derivatives
[0333] 500 ppm of 3-aminobenzoic acid and 500 ppm of 4-aminobenzoic
acid were individually added to separate pH 3.2 buffered solutions
containing 5% sucrose and the SEVs of the resultant solutions were
determined. The SEV of 3-aminobenzoic acid was about 7%, i.e.,
increased the sweetness intensity of 5% sucrose to about 7%. The
SEV of 4-aminobenzoic acid was about 5.5-6%, i.e., increased the
sweetness intensity of 5% sucrose to about 5.5-6%.
* * * * *