U.S. patent application number 12/827642 was filed with the patent office on 2011-03-31 for therapeutic binding molecules. This patent application is currently assigned to NOVARTIS AG. Invention is credited to Andreas ASZODI, Gregorio AVERSA, Jose M. CARBALLIDO HERRERA, Bruce M. HALL, Frank KOLBINGER, Jose W. SALDANHA.
Application Number | 20110076270 12/827642 |
Document ID | / |
Family ID | 34375850 |
Filed Date | 2011-03-31 |
United States Patent Application | 20110076270 |
Kind Code | A1 |
AVERSA; Gregorio ; et al. | March 31, 2011 |
A molecule comprising at least one antigen binding site, comprising in sequence the hypervariable regions CDR1, CDR2 and CDR3, said CDR1 having the amino acid sequence Asn-Tyr-Ile-Ile-His (NYIIH), said CDR2 having the amino acid sequence Tyr-Phe-Asn-Pro-Tyr-Asn-His-Gly-Thr-Lys-Tyr-Asn-Glu-Lys-Phe-Lys-Gly (YFNPYNHGTKYNEKFKG) and said CDR3 having the amino acid sequence Ser-Gly-Pro-Tyr-Ala-Trp-Phe-Asp-Thr (SGPYAWFDT); e.g. further comprising in sequence the hypervariable regions CDR1', CDR2' and CDR3', CDR1' having the amino acid sequence Arg-Ala-Ser-Gln-Asn-Ile-Gly-Thr-Ser-Ile-Gln (RASQNIGTSIQ), CDR2' having the amino acid sequence Ser-Ser-Ser-Glu-Ser-Ile-Ser (SSSESIS) and CDR3' having the amino acid sequence Gln-Gln-Ser-Asn-Thr-Trp-Pro-Phe-Thr (QQSNTWPFT), e.g. a chimeric or humanised antibody, useful as a pharmaceutical.
Inventors: | AVERSA; Gregorio; (Cambridge, MA) ; KOLBINGER; Frank; (Basel, CH) ; CARBALLIDO HERRERA; Jose M.; (Basel, CH) ; ASZODI; Andreas; (Basel, CH) ; SALDANHA; Jose W.; (Basel, CH) ; HALL; Bruce M.; (Basel, CH) |
Assignee: | NOVARTIS AG |
Family ID: | 34375850 |
Appl. No.: | 12/827642 |
Filed: | June 30, 2010 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
11297317 | Dec 8, 2005 | 7825222 | ||
12827642 | ||||
10666332 | Sep 18, 2003 | |||
11297317 | ||||
Current U.S. Class: | 424/133.1 ; 424/139.1; 530/387.3; 530/387.9 |
Current CPC Class: | C07K 2317/565 20130101; C07K 2317/92 20130101; C07K 2317/73 20130101; C07K 2317/75 20130101; C07K 2317/56 20130101; C07K 16/289 20130101; A61P 37/00 20180101; A61K 2039/505 20130101; C07K 2317/24 20130101; C07K 2317/41 20130101; A61P 37/02 20180101; C07K 2317/74 20130101 |
Class at Publication: | 424/133.1 ; 530/387.9; 530/387.3; 424/139.1 |
International Class: | A61K 39/395 20060101 A61K039/395; C07K 16/18 20060101 C07K016/18; A61P 37/02 20060101 A61P037/02 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 49 <210> SEQ ID NO 1 <211> LENGTH: 107 <212>
TYPE: PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric human-murine construct
<220> FEATURE: <223> OTHER INFORMATION: Part of the
amino acid sequence of chimeric light chain <400> SEQUENCE: 1
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 1 5
10 15 Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr
Ser 20 25 30 Ile Gln Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg
Leu Leu Ile 35 40 45 Arg Ser Ser Ser Glu Ser Ile Ser Gly Ile Pro
Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu
Ser Ile Asn Ser Val Glu Ser 65 70 75 80 Glu Asp Ile Ala Asp Tyr Tyr
Cys Gln Gln Ser Asn Thr Trp Pro Phe 85 90 95 Thr Phe Gly Ser Gly
Thr Lys Leu Glu Ile Lys 100 105 <210> SEQ ID NO 2 <211>
LENGTH: 118 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
human-murine construct <220> FEATURE: <223> OTHER
INFORMATION: Part of the amino acid sequence of chimeric heavy
chain <400> SEQUENCE: 2 Glu Val Gln Leu Gln Gln Ser Gly Pro
Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys
Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ile Ile His Trp Val
Lys Gln Glu Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe
Asn Pro Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys
Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 65 70
75 80 Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr
Cys 85 90 95 Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp Gly
Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> SEQ
ID NO 3 <211> LENGTH: 214 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: chimeric human-murine construct <220> FEATURE:
<223> OTHER INFORMATION: Amino acid sequence of chimeric
light chain <400> SEQUENCE: 3 Asp Ile Leu Leu Thr Gln Ser Pro
Ala Ile Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Val Ser Phe Ser
Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser 20 25 30 Ile Gln Trp Tyr
Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 35 40 45 Arg Ser
Ser Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 65
70 75 80 Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Thr Trp
Pro Phe 85 90 95 Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg
Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu
Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val
Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val
Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185
190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> SEQ ID NO 4
<211> LENGTH: 448 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
chimeric human-murine construct <220> FEATURE: <223>
OTHER INFORMATION: Amino acid sequence of chimeric heavy chain
<400> SEQUENCE: 4 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu
Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ile Ile His Trp Val Lys Gln
Glu Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe Asn Pro
Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Arg
Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 65 70 75 80 Met
Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 85 90
95 Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp Gly Gln Gly Thr
100 105 110 Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly
Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn
Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215
220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340
345 350 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445
<210> SEQ ID NO 5 <211> LENGTH: 321 <212> TYPE:
DNA <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric human-murine construct
<220> FEATURE: <223> OTHER INFORMATION: Nucleotide
sequence encoding a polypeptide of SEQ ID NO:1 <400>
SEQUENCE: 5 gacattctgc tgacccagtc tccagccatc ctgtctgtga gtccaggaga
aagagtcagt 60 ttctcctgca gggccagtca gaacattggc acaagcatac
agtggtatca acaaagaaca 120 aatggttctc caaggcttct cataaggtct
tcttctgagt ctatctctgg gatcccttcc 180 aggtttagtg gcagtggatc
agggacagat tttactctta gcatcaacag tgtggagtct 240 gaagatattg
cagattatta ctgtcaacaa agtaatacct ggccattcac gttcggctcg 300
gggaccaagc ttgaaatcaa a 321 <210> SEQ ID NO 6 <211>
LENGTH: 354 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
human-murine construct <220> FEATURE: <223> OTHER
INFORMATION: Nucleotide sequence encoding a polypeptide of SEQ ID
NO:2 <400> SEQUENCE: 6 gaggtgcagc tgcagcagtc aggacctgaa
ctggtaaagc ctggggcttc agtgaagatg 60 tcctgcaagg cctctggata
cacattcact aattatatta tccactgggt gaagcaggag 120 cctggtcagg
gccttgaatg gattggatat tttaatcctt acaatcatgg tactaagtac 180
aatgagaagt tcaaaggcag ggccacacta actgcagaca aatcctccaa cacagcctac
240 atggacctca gcagcctgac ctctgaggac tctgcgatct actactgtgc
aagatcagga 300 ccctatgcct ggtttgacac ctggggccaa gggaccacgg
tcaccgtctc ctca 354 <210> SEQ ID NO 7 <211> LENGTH: 107
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: chimeric human-murine
construct <220> FEATURE: <223> OTHER INFORMATION: Part
of amino acid sequence of humanised light chain designated humV2
(humV2 = VLm) <400> SEQUENCE: 7 Asp Ile Leu Leu Thr Gln Ser
Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe
Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser 20 25 30 Ile Gln Trp
Tyr Gln Gln Lys Thr Asn Gly Ala Pro Arg Leu Leu Ile 35 40 45 Arg
Ser Ser Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55
60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Thr Trp
Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100
105 <210> SEQ ID NO 8 <211> LENGTH: 107 <212>
TYPE: PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric human-murine construct
<220> FEATURE: <223> OTHER INFORMATION: Part of amino
acid sequence of humanised light chain designated humV1 (humV1 =
VLh) <400> SEQUENCE: 8 Asp Ile Leu Leu Thr Gln Ser Pro Ala
Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys
Arg Ala Ser Gln Asn Ile Gly Thr Ser 20 25 30 Ile Gln Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Arg Ser Ser
Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70
75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro
Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105
<210> SEQ ID NO 9 <211> LENGTH: 118 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric human-murine construct
<220> FEATURE: <223> OTHER INFORMATION: Part of amino
acid sequence of humanised heavychain designated VHE <400>
SEQUENCE: 9 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro
Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
Phe Thr Asn Tyr 20 25 30 Ile Ile His Trp Val Lys Gln Glu Pro Gly
Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe Asn Pro Tyr Asn His
Gly Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Arg Ala Thr Leu
Thr Ala Asn Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser
Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg
Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp Gly Gln Gly Thr 100 105 110
Thr Val Thr Val Ser Ser 115 <210> SEQ ID NO 10 <211>
LENGTH: 118 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
human-murine construct <220> FEATURE: <223> OTHER
INFORMATION: Part of amino acid sequence of humanised heavy chain
designated VHQ <400> SEQUENCE: 10 Gln Val Gln Leu Val Glu Ser
Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ile Ile His
Trp Val Lys Gln Glu Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly
Tyr Phe Asn Pro Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe 50 55
60 Lys Gly Arg Ala Thr Leu Thr Ala Asn Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp
Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210>
SEQ ID NO 11 <211> LENGTH: 354 <212> TYPE: DNA
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: chimeric human-murine construct <220>
FEATURE: <223> OTHER INFORMATION: Nucleotide sequence
encoding amino acid sequence SEQ ID NO:9 <400> SEQUENCE: 11
gaggtgcagc tggtggagtc aggagccgaa gtgaaaaagc ctggggcttc agtgaaggtg
60 tcctgcaagg cctctggata cacattcact aattatatta tccactgggt
gaagcaggag 120 cctggtcagg gccttgaatg gattggatat tttaatcctt
acaatcatgg tactaagtac 180 aatgagaagt tcaaaggcag ggccacacta
actgcaaaca aatccatcag cacagcctac 240 atggagctca gcagcctgcg
ctctgaggac actgcggtct actactgtgc aagatcagga 300 ccctatgcct
ggtttgacac ctggggccaa gggaccacgg tcaccgtctc ctca 354 <210>
SEQ ID NO 12 <211> LENGTH: 354 <212> TYPE: DNA
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: chimeric human-murine construct <220>
FEATURE: <223> OTHER INFORMATION: Nucleotide sequence
encoding amino acid sequence SEQ ID NO:10 <400> SEQUENCE: 12
caggtgcagc tggtggagtc aggagccgaa gtgaaaaagc ctggggcttc agtgaaggtg
60 tcctgcaagg cctctggata cacattcact aattatatta tccactgggt
gaagcaggag 120 cctggtcagg gccttgaatg gattggatat tttaatcctt
acaatcatgg tactaagtac 180 aatgagaagt tcaaaggcag ggccacacta
actgcaaaca aatccatcag cacagcctac 240 atggagctca gcagcctgcg
ctctgaggac actgcggtct actactgtgc aagatcagga 300 ccctatgcct
ggtttgacac ctggggccaa gggaccacgg tcaccgtctc ctca 354 <210>
SEQ ID NO 13 <211> LENGTH: 321 <212> TYPE: DNA
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: chimeric human-murine construct <220>
FEATURE: <223> OTHER INFORMATION: Nucleotide sequence
encoding amino acid sequence SEQ ID NO:7 <400> SEQUENCE: 13
gacattctgc tgacccagtc tccagccacc ctgtctctga gtccaggaga aagagccact
60 ttctcctgca gggccagtca gaacattggc acaagcatac agtggtatca
acaaaaaaca 120 aatggtgctc caaggcttct cataaggtct tcttctgagt
ctatctctgg gatcccttcc 180 aggtttagtg gcagtggatc agggacagat
tttactctta ccatcagcag tctggagcct 240 gaagattttg cagtgtatta
ctgtcaacaa agtaatacct ggccattcac gttcggccag 300 gggaccaagc
tggagatcaa a 321 <210> SEQ ID NO 14 <211> LENGTH: 321
<212> TYPE: DNA <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: chimeric human-murine
construct <220> FEATURE: <223> OTHER INFORMATION:
Nucleotide sequence encoding amino acid sequence SEQ ID NO:8
<400> SEQUENCE: 14 gacattctgc tgacccagtc tccagccacc
ctgtctctga gtccaggaga aagagccact 60 ctctcctgca gggccagtca
gaacattggc acaagcatac agtggtatca acaaaaacca 120 ggtcaggctc
caaggcttct cataaggtct tcttctgagt ctatctctgg gatcccttcc 180
aggtttagtg gcagtggatc agggacagat tttactctta ccatcagcag tctggagcct
240 gaagattttg cagtgtatta ctgtcaacaa agtaatacct ggccattcac
gttcggccag 300 gggaccaagc tggagatcaa a 321 <210> SEQ ID NO 15
<211> LENGTH: 8687 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic expression vector <220> FEATURE:
<223> OTHER INFORMATION: Nucleotide sequence of the
expression vector HCMV-G1 HuA6-VHQ (Complete DNA Sequence of a
humanised heavy chain expression vector comprising SEQ ID NO:12
(VHQ) from 3921-4274) <400> SEQUENCE: 15 agctttttgc
aaaagcctag gcctccaaaa aagcctcctc actacttctg gaatagctca 60
gaggccgagg cggcctcggc ctctgcataa ataaaaaaaa ttagtcagcc atggggcgga
120 gaatgggcgg aactgggcgg agttaggggc gggatgggcg gagttagggg
cgggactatg 180 gttgctgact aattgagatg catgctttgc atacttctgc
ctgctgggga gcctggttgc 240 tgactaattg agatgcatgc tttgcatact
tctgcctgct ggggagcctg gggactttcc 300 acaccctaac tgacacacat
tccacagctg cctcgcgcgt ttcggtgatg acggtgaaaa 360 cctctgacac
atgcagctcc cggagacggt cacagcttgt ctgtaagcgg atgccgggag 420
cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggcg cagccatgac
480 ccagtcacgt agcgatagcg gagtgtatac tggcttaact atgcggcatc
agagcagatt 540 gtactgagag tgcaccatat gcggtgtgaa ataccgcaca
gatgcgtaag gagaaaatac 600 cgcatcaggc gctcttccgc ttcctcgctc
actgactcgc tgcgctcggt cgttcggctg 660 cggcgagcgg tatcagctca
ctcaaaggcg gtaatacggt tatccacaga atcaggggat 720 aacgcaggaa
agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc 780
gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc
840 tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt
tccccctgga 900 agctccctcg tgcgctctcc tgttccgacc ctgccgctta
ccggatacct gtccgccttt 960 ctcccttcgg gaagcgtggc gctttctcat
agctcacgct gtaggtatct cagttcggtg 1020 taggtcgttc gctccaagct
gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc 1080 gccttatccg
gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg 1140
gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc
1200 ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat
ctgcgctctg 1260 ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt
gatccggcaa acaaaccacc 1320 gctggtagcg gtggtttttt tgtttgcaag
cagcagatta cgcgcagaaa aaaaggatct 1380 caagaagatc ctttgatctt
ttctacgggg tctgacgctc agtggaacga aaactcacgt 1440 taagggattt
tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa 1500
aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa
1560 tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc
catagttgcc 1620 tgactccccg tcgtgtagat aactacgata cgggagggct
taccatctgg ccccagtgct 1680 gcaatgatac cgcgagaccc acgctcaccg
gctccagatt tatcagcaat aaaccagcca 1740 gccggaaggg ccgagcgcag
aagtggtcct gcaactttat ccgcctccat ccagtctatt 1800 aattgttgcc
gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt 1860
gccattgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc
1920 ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa
agcggttagc 1980 tccttcggtc ctccgatcgt tgtcagaagt aagttggccg
cagtgttatc actcatggtt 2040 atggcagcac tgcataattc tcttactgtc
atgccatccg taagatgctt ttctgtgact 2100 ggtgagtact caaccaagtc
attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc 2160 ccggcgtcaa
cacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt 2220
ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg
2280 atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac
cagcgtttct 2340 gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg
gaataagggc gacacggaaa 2400 tgttgaatac tcatactctt cctttttcaa
tattattgaa gcatttatca gggttattgt 2460 ctcatgagcg gatacatatt
tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc 2520 acatttcccc
gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc 2580
tataaaaata ggcgtatcac gaggcccttt cgtcttcaag aattcagctt ggctgcagtg
2640 aataataaaa tgtgtgtttg tccgaaatac gcgttttgag atttctgtcg
ccgactaaat 2700 tcatgtcgcg cgatagtggt gtttatcgcc gatagagatg
gcgatattgg aaaaatcgat 2760 atttgaaaat atggcatatt gaaaatgtcg
ccgatgtgag tttctgtgta actgatatcg 2820 ccatttttcc aaaagtgatt
tttgggcata cgcgatatct ggcgatagcg cttatatcgt 2880 ttacggggga
tggcgataga cgactttggt gacttgggcg attctgtgtg tcgcaaatat 2940
cgcagtttcg atataggtga cagacgatat gaggctatat cgccgataga ggcgacatca
3000 agctggcaca tggccaatgc atatcgatct atacattgaa tcaatattgg
ccattagcca 3060 tattattcat tggttatata gcataaatca atattggcta
ttggccattg catacgttgt 3120 atccatatca taatatgtac atttatattg
gctcatgtcc aacattaccg ccatgttgac 3180 attgattatt gactagttat
taatagtaat caattacggg gtcattagtt catagcccat 3240 atatggagtt
ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg 3300
acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt
3360 tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca
gtacatcaag 3420 tgtatcatat gccaagtacg ccccctattg acgtcaatga
cggtaaatgg cccgcctggc 3480 attatgccca gtacatgacc ttatgggact
ttcctacttg gcagtacatc tacgtattag 3540 tcatcgctat taccatggtg
atgcggtttt ggcagtacat caatgggcgt ggatagcggt 3600 ttgactcacg
gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc 3660
accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg
3720 gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcgtttagtg
aaccgtcaga 3780 tcgcctggag acgccatcca cgctgttttg acctccatag
aagacaccgg gaccgatcca 3840 gcctccgcaa gcttgccgcc accatggact
ggacctggag ggtgttctgc ctgctggccg 3900 tggcccccgg cgcccacagc
caggtgcagc tggtggagtc aggagccgaa gtgaaaaagc 3960 ctggggcttc
agtgaaggtg tcctgcaagg cctctggata cacattcact aattatatta 4020
tccactgggt gaagcaggag cctggtcagg gccttgaatg gattggatat tttaatcctt
4080 acaatcatgg tactaagtac aatgagaagt tcaaaggcag ggccacacta
actgcaaaca 4140 aatccatcag cacagcctac atggagctca gcagcctgcg
ctctgaggac actgcggtct 4200 actactgtgc aagatcagga ccctatgcct
ggtttgacac ctggggccaa gggaccacgg 4260 tcaccgtctc ctcaggtgag
ttctagaagg atcccaagct agctttctgg ggcaggccag 4320 gcctgacctt
ggctttgggg cagggagggg gctaaggtga ggcaggtggc gccagccagg 4380
tgcacaccca atgcccatga gcccagacac tggacgctga acctcgcgga cagttaagaa
4440 cccaggggcc tctgcgccct gggcccagct ctgtcccaca ccgcggtcac
atggcaccac 4500 ctctcttgca gcctccacca agggcccatc ggtcttcccc
ctggcaccct cctccaagag 4560 cacctctggg ggcacagcgg ccctgggctg
cctggtcaag gactacttcc ccgaaccggt 4620 gacggtgtcg tggaactcag
gcgccctgac cagcggcgtg cacaccttcc cggctgtcct 4680 acagtcctca
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg 4740
cacccagacc tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa
4800 agttggtgag aggccagcac agggagggag ggtgtctgct ggaagccagg
ctcagcgctc 4860 ctgcctggac gcatcccggc tatgcagccc cagtccaggg
cagcaaggca ggccccgtct 4920 gcctcttcac ccggaggcct ctgcccgccc
cactcatgct cagggagagg gtcttctggc 4980 tttttcccca ggctctgggc
aggcacaggc taggtgcccc taacccaggc cctgcacaca 5040 aaggggcagg
tgctgggctc agacctgcca agagccatat ccgggaggac cctgcccctg 5100
acctaagccc accccaaagg ccaaactctc cactccctca gctcggacac cttctctcct
5160 cccagattcc agtaactccc aatcttctct ctgcagagcc caaatcttgt
gacaaaactc 5220 acacatgccc accgtgccca ggtaagccag cccaggcctc
gccctccagc tcaaggcggg 5280 acaggtgccc tagagtagcc tgcatccagg
gacaggcccc agccgggtgc tgacacgtcc 5340 acctccatct cttcctcagc
acctgaactc ctggggggac cgtcagtctt cctcttcccc 5400 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 5460
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
5520 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 5580 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 5640 aacaaagccc tcccagcccc catcgagaaa
accatctcca aagccaaagg tgggacccgt 5700 ggggtgcgag ggccacatgg
acagaggccg gctcggccca ccctctgccc tgagagtgac 5760 cgctgtacca
acctctgtcc ctacagggca gccccgagaa ccacaggtgt acaccctgcc 5820
cccatcccgg gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt
5880 ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga
acaactacaa 5940 gaccacgcct cccgtgctgg actccgacgg ctccttcttc
ctctacagca agctcaccgt 6000 ggacaagagc aggtggcagc aggggaacgt
cttctcatgc tccgtgatgc atgaggctct 6060 gcacaaccac tacacgcaga
agagcctctc cctgtctccg ggtaaatgag tgcgacggcc 6120 ggcaagcccc
cgctccccgg gctctcgcgg tcgcacgagg atgcttggca cgtaccccct 6180
gtacatactt cccgggcgcc cagcatggaa ataaagcacc cagcgctgcc ctgggcccct
6240 gcgagactgt gatggttctt tccacgggtc aggccgagtc tgaggcctga
gtggcatgag 6300 atctgatatc atcgatgaat tcgagctcgg tacccgggga
tcgatccaga catgataaga 6360 tacattgatg agtttggaca aaccacaact
agaatgcagt gaaaaaaatg ctttatttgt 6420 gaaatttgtg atgctattgc
tttatttgta accattataa gctgcaataa acaagttaac 6480 aacaacaatt
gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa 6540
agcaagtaaa acctctacaa atgtggtatg gctgattatg atctctagtc aaggcactat
6600 acatcaaata ttccttatta acccctttac aaattaaaaa gctaaaggta
cacaattttt 6660 gagcatagtt attaatagca gacactctat gcctgtgtgg
agtaagaaaa aacagtatgt 6720 tatgattata actgttatgc ctacttataa
aggttacaga atatttttcc ataattttct 6780 tgtatagcag tgcagctttt
tcctttgtgg tgtaaatagc aaagcaagca agagttctat 6840 tactaaacac
agcatgactc aaaaaactta gcaattctga aggaaagtcc ttggggtctt 6900
ctacctttct cttctttttt ggaggagtag aatgttgaga gtcagcagta gcctcatcat
6960 cactagatgg catttcttct gagcaaaaca ggttttcctc attaaaggca
ttccaccact 7020 gctcccattc atcagttcca taggttggaa tctaaaatac
acaaacaatt agaatcagta 7080 gtttaacaca ttatacactt aaaaatttta
tatttacctt agagctttaa atctctgtag 7140 gtagtttgtc caattatgtc
acaccacaga agtaaggttc cttcacaaag atccgggacc 7200 aaagcggcca
tcgtgcctcc ccactcctgc agttcggggg catggatgcg cggatagccg 7260
ctgctggttt cctggatgcc gacggatttg cactgccggt agaactccgc gaggtcgtcc
7320 agcctcaggc agcagctgaa ccaactcgcg aggggatcga gcccggggtg
ggcgaagaac 7380 tccagcatga gatccccgcg ctggaggatc atccagccgg
cgtcccggaa aacgattccg 7440 aagcccaacc tttcatagaa ggcggcggtg
gaatcgaaat ctcgtgatgg caggttgggc 7500 gtcgcttggt cggtcatttc
gaaccccaga gtcccgctca gaagaactcg tcaagaaggc 7560 gatagaaggc
gatgcgctgc gaatcgggag cggcgatacc gtaaagcacg aggaagcggt 7620
cagcccattc gccgccaagc tcttcagcaa tatcacgggt agccaacgct atgtcctgat
7680 agcggtccgc cacacccagc cggccacagt cgatgaatcc agaaaagcgg
ccattttcca 7740 ccatgatatt cggcaagcag gcatcgccat gggtcacgac
gagatcctcg ccgtcgggca 7800 tgcgcgcctt gagcctggcg aacagttcgg
ctggcgcgag cccctgatgc tcttcgtcca 7860 gatcatcctg atcgacaaga
ccggcttcca tccgagtacg tgctcgctcg atgcgatgtt 7920 tcgcttggtg
gtcgaatggg caggtagccg gatcaagcgt atgcagccgc cgcattgcat 7980
cagccatgat ggatactttc tcggcaggag caaggtgaga tgacaggaga tcctgccccg
8040 gcacttcgcc caatagcagc cagtcccttc ccgcttcagt gacaacgtcg
agcacagctg 8100 cgcaaggaac gcccgtcgtg gccagccacg atagccgcgc
tgcctcgtcc tgcagttcat 8160 tcagggcacc ggacaggtcg gtcttgacaa
aaagaaccgg gcgcccctgc gctgacagcc 8220 ggaacacggc ggcatcagag
cagccgattg tctgttgtgc ccagtcatag ccgaatagcc 8280 tctccaccca
agcggccgga gaacctgcgt gcaatccatc ttgttcaatc atgcgaaacg 8340
atcctcatcc tgtctcttga tcagatcttg atcccctgcg ccatcagatc cttggcggca
8400 agaaagccat ccagtttact ttgcagggct tcccaacctt accagagggc
gccccagctg 8460 gcaattccgg ttcgcttgct gtccataaaa ccgcccagtc
tagctatcgc catgtaagcc 8520 cactgcaagc tacctgcttt ctctttgcgc
ttgcgttttc ccttgtccag atagcccagt 8580 agctgacatt catccggggt
cagcaccgtt tctgcggact ggctttctac gtgttccgct 8640 tcctttagca
gcccttgcgc cctgagtgct tgcggcagcg tgaagct 8687 <210> SEQ ID NO
16 <211> LENGTH: 8687 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic expression vector <220> FEATURE:
<223> OTHER INFORMATION: Nucleotide sequence of the
expression vector HCMV-G1 HuA6-VHE (Complete DNA Sequence of a
humanised heavy chain expression vector comprising SEQ ID NO: 11
(VHE) from 3921-4274) <400> SEQUENCE: 16 agctttttgc
aaaagcctag gcctccaaaa aagcctcctc actacttctg gaatagctca 60
gaggccgagg cggcctcggc ctctgcataa ataaaaaaaa ttagtcagcc atggggcgga
120 gaatgggcgg aactgggcgg agttaggggc gggatgggcg gagttagggg
cgggactatg 180 gttgctgact aattgagatg catgctttgc atacttctgc
ctgctgggga gcctggttgc 240 tgactaattg agatgcatgc tttgcatact
tctgcctgct ggggagcctg gggactttcc 300 acaccctaac tgacacacat
tccacagctg cctcgcgcgt ttcggtgatg acggtgaaaa 360 cctctgacac
atgcagctcc cggagacggt cacagcttgt ctgtaagcgg atgccgggag 420
cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggcg cagccatgac
480 ccagtcacgt agcgatagcg gagtgtatac tggcttaact atgcggcatc
agagcagatt 540 gtactgagag tgcaccatat gcggtgtgaa ataccgcaca
gatgcgtaag gagaaaatac 600 cgcatcaggc gctcttccgc ttcctcgctc
actgactcgc tgcgctcggt cgttcggctg 660 cggcgagcgg tatcagctca
ctcaaaggcg gtaatacggt tatccacaga atcaggggat 720 aacgcaggaa
agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc 780
gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc
840 tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt
tccccctgga 900 agctccctcg tgcgctctcc tgttccgacc ctgccgctta
ccggatacct gtccgccttt 960 ctcccttcgg gaagcgtggc gctttctcat
agctcacgct gtaggtatct cagttcggtg 1020 taggtcgttc gctccaagct
gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc 1080 gccttatccg
gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg 1140
gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc
1200 ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat
ctgcgctctg 1260 ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt
gatccggcaa acaaaccacc 1320 gctggtagcg gtggtttttt tgtttgcaag
cagcagatta cgcgcagaaa aaaaggatct 1380 caagaagatc ctttgatctt
ttctacgggg tctgacgctc agtggaacga aaactcacgt 1440 taagggattt
tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa 1500
aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa
1560 tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc
catagttgcc 1620 tgactccccg tcgtgtagat aactacgata cgggagggct
taccatctgg ccccagtgct 1680 gcaatgatac cgcgagaccc acgctcaccg
gctccagatt tatcagcaat aaaccagcca 1740 gccggaaggg ccgagcgcag
aagtggtcct gcaactttat ccgcctccat ccagtctatt 1800 aattgttgcc
gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt 1860
gccattgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc
1920 ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa
agcggttagc 1980 tccttcggtc ctccgatcgt tgtcagaagt aagttggccg
cagtgttatc actcatggtt 2040 atggcagcac tgcataattc tcttactgtc
atgccatccg taagatgctt ttctgtgact 2100 ggtgagtact caaccaagtc
attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc 2160 ccggcgtcaa
cacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt 2220
ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg
2280 atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac
cagcgtttct 2340 gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg
gaataagggc gacacggaaa 2400 tgttgaatac tcatactctt cctttttcaa
tattattgaa gcatttatca gggttattgt 2460 ctcatgagcg gatacatatt
tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc 2520 acatttcccc
gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc 2580
tataaaaata ggcgtatcac gaggcccttt cgtcttcaag aattcagctt ggctgcagtg
2640 aataataaaa tgtgtgtttg tccgaaatac gcgttttgag atttctgtcg
ccgactaaat 2700 tcatgtcgcg cgatagtggt gtttatcgcc gatagagatg
gcgatattgg aaaaatcgat 2760 atttgaaaat atggcatatt gaaaatgtcg
ccgatgtgag tttctgtgta actgatatcg 2820 ccatttttcc aaaagtgatt
tttgggcata cgcgatatct ggcgatagcg cttatatcgt 2880 ttacggggga
tggcgataga cgactttggt gacttgggcg attctgtgtg tcgcaaatat 2940
cgcagtttcg atataggtga cagacgatat gaggctatat cgccgataga ggcgacatca
3000 agctggcaca tggccaatgc atatcgatct atacattgaa tcaatattgg
ccattagcca 3060 tattattcat tggttatata gcataaatca atattggcta
ttggccattg catacgttgt 3120 atccatatca taatatgtac atttatattg
gctcatgtcc aacattaccg ccatgttgac 3180 attgattatt gactagttat
taatagtaat caattacggg gtcattagtt catagcccat 3240 atatggagtt
ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg 3300
acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt
3360 tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca
gtacatcaag 3420 tgtatcatat gccaagtacg ccccctattg acgtcaatga
cggtaaatgg cccgcctggc 3480 attatgccca gtacatgacc ttatgggact
ttcctacttg gcagtacatc tacgtattag 3540 tcatcgctat taccatggtg
atgcggtttt ggcagtacat caatgggcgt ggatagcggt 3600 ttgactcacg
gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc 3660
accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg
3720 gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcgtttagtg
aaccgtcaga 3780 tcgcctggag acgccatcca cgctgttttg acctccatag
aagacaccgg gaccgatcca 3840 gcctccgcaa gcttgccgcc accatggact
ggacctggag ggtgttctgc ctgctggccg 3900 tggcccccgg cgcccacagc
gaggtgcagc tggtggagtc aggagccgaa gtgaaaaagc 3960 ctggggcttc
agtgaaggtg tcctgcaagg cctctggata cacattcact aattatatta 4020
tccactgggt gaagcaggag cctggtcagg gccttgaatg gattggatat tttaatcctt
4080 acaatcatgg tactaagtac aatgagaagt tcaaaggcag ggccacacta
actgcaaaca 4140 aatccatcag cacagcctac atggagctca gcagcctgcg
ctctgaggac actgcggtct 4200 actactgtgc aagatcagga ccctatgcct
ggtttgacac ctggggccaa gggaccacgg 4260 tcaccgtctc ctcaggtgag
ttctagaagg atcccaagct agctttctgg ggcaggccag 4320 gcctgacctt
ggctttgggg cagggagggg gctaaggtga ggcaggtggc gccagccagg 4380
tgcacaccca atgcccatga gcccagacac tggacgctga acctcgcgga cagttaagaa
4440 cccaggggcc tctgcgccct gggcccagct ctgtcccaca ccgcggtcac
atggcaccac 4500 ctctcttgca gcctccacca agggcccatc ggtcttcccc
ctggcaccct cctccaagag 4560 cacctctggg ggcacagcgg ccctgggctg
cctggtcaag gactacttcc ccgaaccggt 4620 gacggtgtcg tggaactcag
gcgccctgac cagcggcgtg cacaccttcc cggctgtcct 4680 acagtcctca
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg 4740
cacccagacc tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa
4800 agttggtgag aggccagcac agggagggag ggtgtctgct ggaagccagg
ctcagcgctc 4860 ctgcctggac gcatcccggc tatgcagccc cagtccaggg
cagcaaggca ggccccgtct 4920 gcctcttcac ccggaggcct ctgcccgccc
cactcatgct cagggagagg gtcttctggc 4980 tttttcccca ggctctgggc
aggcacaggc taggtgcccc taacccaggc cctgcacaca 5040 aaggggcagg
tgctgggctc agacctgcca agagccatat ccgggaggac cctgcccctg 5100
acctaagccc accccaaagg ccaaactctc cactccctca gctcggacac cttctctcct
5160 cccagattcc agtaactccc aatcttctct ctgcagagcc caaatcttgt
gacaaaactc 5220 acacatgccc accgtgccca ggtaagccag cccaggcctc
gccctccagc tcaaggcggg 5280 acaggtgccc tagagtagcc tgcatccagg
gacaggcccc agccgggtgc tgacacgtcc 5340 acctccatct cttcctcagc
acctgaactc ctggggggac cgtcagtctt cctcttcccc 5400 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 5460
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
5520 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 5580 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 5640 aacaaagccc tcccagcccc catcgagaaa
accatctcca aagccaaagg tgggacccgt 5700 ggggtgcgag ggccacatgg
acagaggccg gctcggccca ccctctgccc tgagagtgac 5760 cgctgtacca
acctctgtcc ctacagggca gccccgagaa ccacaggtgt acaccctgcc 5820
cccatcccgg gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt
5880 ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga
acaactacaa 5940 gaccacgcct cccgtgctgg actccgacgg ctccttcttc
ctctacagca agctcaccgt 6000 ggacaagagc aggtggcagc aggggaacgt
cttctcatgc tccgtgatgc atgaggctct 6060 gcacaaccac tacacgcaga
agagcctctc cctgtctccg ggtaaatgag tgcgacggcc 6120 ggcaagcccc
cgctccccgg gctctcgcgg tcgcacgagg atgcttggca cgtaccccct 6180
gtacatactt cccgggcgcc cagcatggaa ataaagcacc cagcgctgcc ctgggcccct
6240 gcgagactgt gatggttctt tccacgggtc aggccgagtc tgaggcctga
gtggcatgag 6300 atctgatatc atcgatgaat tcgagctcgg tacccgggga
tcgatccaga catgataaga 6360 tacattgatg agtttggaca aaccacaact
agaatgcagt gaaaaaaatg ctttatttgt 6420 gaaatttgtg atgctattgc
tttatttgta accattataa gctgcaataa acaagttaac 6480 aacaacaatt
gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa 6540
agcaagtaaa acctctacaa atgtggtatg gctgattatg atctctagtc aaggcactat
6600 acatcaaata ttccttatta acccctttac aaattaaaaa gctaaaggta
cacaattttt 6660 gagcatagtt attaatagca gacactctat gcctgtgtgg
agtaagaaaa aacagtatgt 6720 tatgattata actgttatgc ctacttataa
aggttacaga atatttttcc ataattttct 6780 tgtatagcag tgcagctttt
tcctttgtgg tgtaaatagc aaagcaagca agagttctat 6840 tactaaacac
agcatgactc aaaaaactta gcaattctga aggaaagtcc ttggggtctt 6900
ctacctttct cttctttttt ggaggagtag aatgttgaga gtcagcagta gcctcatcat
6960 cactagatgg catttcttct gagcaaaaca ggttttcctc attaaaggca
ttccaccact 7020 gctcccattc atcagttcca taggttggaa tctaaaatac
acaaacaatt agaatcagta 7080 gtttaacaca ttatacactt aaaaatttta
tatttacctt agagctttaa atctctgtag 7140 gtagtttgtc caattatgtc
acaccacaga agtaaggttc cttcacaaag atccgggacc 7200 aaagcggcca
tcgtgcctcc ccactcctgc agttcggggg catggatgcg cggatagccg 7260
ctgctggttt cctggatgcc gacggatttg cactgccggt agaactccgc gaggtcgtcc
7320 agcctcaggc agcagctgaa ccaactcgcg aggggatcga gcccggggtg
ggcgaagaac 7380 tccagcatga gatccccgcg ctggaggatc atccagccgg
cgtcccggaa aacgattccg 7440 aagcccaacc tttcatagaa ggcggcggtg
gaatcgaaat ctcgtgatgg caggttgggc 7500 gtcgcttggt cggtcatttc
gaaccccaga gtcccgctca gaagaactcg tcaagaaggc 7560 gatagaaggc
gatgcgctgc gaatcgggag cggcgatacc gtaaagcacg aggaagcggt 7620
cagcccattc gccgccaagc tcttcagcaa tatcacgggt agccaacgct atgtcctgat
7680 agcggtccgc cacacccagc cggccacagt cgatgaatcc agaaaagcgg
ccattttcca 7740 ccatgatatt cggcaagcag gcatcgccat gggtcacgac
gagatcctcg ccgtcgggca 7800 tgcgcgcctt gagcctggcg aacagttcgg
ctggcgcgag cccctgatgc tcttcgtcca 7860 gatcatcctg atcgacaaga
ccggcttcca tccgagtacg tgctcgctcg atgcgatgtt 7920 tcgcttggtg
gtcgaatggg caggtagccg gatcaagcgt atgcagccgc cgcattgcat 7980
cagccatgat ggatactttc tcggcaggag caaggtgaga tgacaggaga tcctgccccg
8040 gcacttcgcc caatagcagc cagtcccttc ccgcttcagt gacaacgtcg
agcacagctg 8100 cgcaaggaac gcccgtcgtg gccagccacg atagccgcgc
tgcctcgtcc tgcagttcat 8160 tcagggcacc ggacaggtcg gtcttgacaa
aaagaaccgg gcgcccctgc gctgacagcc 8220 ggaacacggc ggcatcagag
cagccgattg tctgttgtgc ccagtcatag ccgaatagcc 8280 tctccaccca
agcggccgga gaacctgcgt gcaatccatc ttgttcaatc atgcgaaacg 8340
atcctcatcc tgtctcttga tcagatcttg atcccctgcg ccatcagatc cttggcggca
8400 agaaagccat ccagtttact ttgcagggct tcccaacctt accagagggc
gccccagctg 8460 gcaattccgg ttcgcttgct gtccataaaa ccgcccagtc
tagctatcgc catgtaagcc 8520 cactgcaagc tacctgcttt ctctttgcgc
ttgcgttttc ccttgtccag atagcccagt 8580 agctgacatt catccggggt
cagcaccgtt tctgcggact ggctttctac gtgttccgct 8640 tcctttagca
gcccttgcgc cctgagtgct tgcggcagcg tgaagct 8687 <210> SEQ ID NO
17 <211> LENGTH: 9400 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic expression vector <220> FEATURE:
<223> OTHER INFORMATION: Nucleotide sequence of the
expression vector HCMV-K HuAb-VL1 hum V1 (Complete DNA Sequence of
a humanised light chain expression vector comprising SEQ ID NO: 14
(humV1=VLh) from 3964-4284 <400> SEQUENCE: 17 ctagcttttt
gcaaaagcct aggcctccaa aaaagcctcc tcactacttc tggaatagct 60
cagaggccga ggcggcctcg gcctctgcat aaataaaaaa aattagtcag ccatggggcg
120 gagaatgggc ggaactgggc ggagttaggg gcgggatggg cggagttagg
ggcgggacta 180 tggttgctga ctaattgaga tgcatgcttt gcatacttct
gcctgctggg gagcctggtt 240 gctgactaat tgagatgcat gctttgcata
cttctgcctg ctggggagcc tggggacttt 300 ccacacccta actgacacac
attccacagc tgcctcgcgc gtttcggtga tgacggtgaa 360 aacctctgac
acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg 420
agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg cgcagccatg
480 acccagtcac gtagcgatag cggagtgtat actggcttaa ctatgcggca
tcagagcaga 540 ttgtactgag agtgcaccat atgcggtgtg aaataccgca
cagatgcgta aggagaaaat 600 accgcatcag gcgctcttcc gcttcctcgc
tcactgactc gctgcgctcg gtcgttcggc 660 tgcggcgagc ggtatcagct
cactcaaagg cggtaatacg gttatccaca gaatcagggg 720 ataacgcagg
aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg 780
ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac
840 gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg
tttccccctg 900 gaagctccct cgtgcgctct cctgttccga ccctgccgct
taccggatac ctgtccgcct 960 ttctcccttc gggaagcgtg gcgctttctc
atagctcacg ctgtaggtat ctcagttcgg 1020 tgtaggtcgt tcgctccaag
ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct 1080 gcgccttatc
cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac 1140
tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt
1200 tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt
atctgcgctc 1260 tgctgaagcc agttaccttc ggaaaaagag ttggtagctc
ttgatccggc aaacaaacca 1320 ccgctggtag cggtggtttt tttgtttgca
agcagcagat tacgcgcaga aaaaaaggat 1380 ctcaagaaga tcctttgatc
ttttctacgg ggtctgacgc tcagtggaac gaaaactcac 1440 gttaagggat
tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt 1500
aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc
1560 aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca
tccatagttg 1620 cctgactccc cgtcgtgtag ataactacga tacgggaggg
cttaccatct ggccccagtg 1680 ctgcaatgat accgcgagac ccacgctcac
cggctccaga tttatcagca ataaaccagc 1740 cagccggaag ggccgagcgc
agaagtggtc ctgcaacttt atccgcctcc atccagtcta 1800 ttaattgttg
ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg 1860
ttgccattgc tgcaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct
1920 ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa
aaagcggtta 1980 gctccttcgg tcctccgatc gttgtcagaa gtaagttggc
cgcagtgtta tcactcatgg 2040 ttatggcagc actgcataat tctcttactg
tcatgccatc cgtaagatgc ttttctgtga 2100 ctggtgagta ctcaaccaag
tcattctgag aatagtgtat gcggcgaccg agttgctctt 2160 gcccggcgtc
aacacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca 2220
ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt
2280 cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc
accagcgttt 2340 ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa
gggaataagg gcgacacgga 2400 aatgttgaat actcatactc ttcctttttc
aatattattg aagcatttat cagggttatt 2460 gtctcatgag cggatacata
tttgaatgta tttagaaaaa taaacaaata ggggttccgc 2520 gcacatttcc
ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa 2580
cctataaaaa taggcgtatc acgaggccct ttcgtcttca agaattcagc ttggctgcag
2640 tgaataataa aatgtgtgtt tgtccgaaat acgcgttttg agatttctgt
cgccgactaa 2700 attcatgtcg cgcgatagtg gtgtttatcg ccgatagaga
tggcgatatt ggaaaaatcg 2760 atatttgaaa atatggcata ttgaaaatgt
cgccgatgtg agtttctgtg taactgatat 2820 cgccattttt ccaaaagtga
tttttgggca tacgcgatat ctggcgatag cgcttatatc 2880 gtttacgggg
gatggcgata gacgactttg gtgacttggg cgattctgtg tgtcgcaaat 2940
atcgcagttt cgatataggt gacagacgat atgaggctat atcgccgata gaggcgacat
3000 caagctggca catggccaat gcatatcgat ctatacattg aatcaatatt
ggccattagc 3060 catattattc attggttata tagcataaat caatattggc
tattggccat tgcatacgtt 3120 gtatccatat cataatatgt acatttatat
tggctcatgt ccaacattac cgccatgttg 3180 acattgatta ttgactagtt
attaatagta atcaattacg gggtcattag ttcatagccc 3240 atatatggag
ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 3300
cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac
3360 tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg
cagtacatca 3420 agtgtatcat atgccaagta cgccccctat tgacgtcaat
gacggtaaat ggcccgcctg 3480 gcattatgcc cagtacatga ccttatggga
ctttcctact tggcagtaca tctacgtatt 3540 agtcatcgct attaccatgg
tgatgcggtt ttggcagtac atcaatgggc gtggatagcg 3600 gtttgactca
cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg 3660
gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat
3720 gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctcgtttag
tgaaccgtca 3780 gatcgcctgg agacgccatc cacgctgttt tgacctccat
agaagacacc gggaccgatc 3840 cagcctccgc aagcttgata tcgaattcct
gcagcccggg ggatccgccc gcttgccgcc 3900 accatggaga cccccgccca
gctgctgttc ctgctgctgc tgtggctgcc cgacaccacc 3960 ggcgacattc
tgctgaccca gtctccagcc accctgtctc tgagtccagg agaaagagcc 4020
actctctcct gcagggccag tcagaacatt ggcacaagca tacagtggta tcaacaaaaa
4080 ccaggtcagg ctccaaggct tctcataagg tcttcttctg agtctatctc
tgggatccct 4140 tccaggttta gtggcagtgg atcagggaca gattttactc
ttaccatcag cagtctggag 4200 cctgaagatt ttgcagtgta ttactgtcaa
caaagtaata cctggccatt cacgttcggc 4260 caggggacca agctggagat
caaacgtgag tattctagaa agatcctaga attctaaact 4320 ctgagggggt
cggatgacgt ggccattctt tgcctaaagc attgagttta ctgcaaggtc 4380
agaaaagcat gcaaagccct cagaatggct gcaaagagct ccaacaaaac aatttagaac
4440 tttattaagg aataggggga agctaggaag aaactcaaaa catcaagatt
ttaaatacgc 4500 ttcttggtct ccttgctata attatctggg ataagcatgc
tgttttctgt ctgtccctaa 4560 catgccctgt gattatccgc aaacaacaca
cccaagggca gaactttgtt acttaaacac 4620 catcctgttt gcttctttcc
tcaggaactg tggctgcacc atctgtcttc atcttcccgc 4680 catctgatga
gcagttgaaa tctggaactg cctctgttgt gtgcctgctg aataacttct 4740
atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg ggtaactccc
4800 aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc
agcaccctga 4860 cgctgagcaa agcagactac gagaaacaca aagtctacgc
ctgcgaagtc acccatcagg 4920 gcctgagctc gcccgtcaca aagagcttca
acaggggaga gtgttagagg gagaagtgcc 4980 cccacctgct cctcagttcc
agcctgaccc cctcccatcc tttggcctct gacccttttt 5040 ccacagggga
cctaccccta ttgcggtcct ccagctcatc tttcacctca cccccctcct 5100
cctccttggc tttaattatg ctaatgttgg aggagaatga ataaataaag tgaatctttg
5160 cacctgtggt ttctctcttt cctcatttaa taattattat ctgttgttta
ccaactactc 5220 aatttctctt ataagggact aaatatgtag tcatcctaag
gcgcataacc atttataaaa 5280 atcatccttc attctatttt accctatcat
cctctgcaag acagtcctcc ctcaaaccca 5340 caagccttct gtcctcacag
tcccctgggc catggtagga gagacttgct tccttgtttt 5400 cccctcctca
gcaagccctc atagtccttt ttaagggtga caggtcttac agtcatatat 5460
cctttgattc aattccctga gaatcaacca aagcaaattt ttcaaaagaa gaaacctgct
5520 ataaagagaa tcattcattg caacatgata taaaataaca acacaataaa
agcaattaaa 5580 taaacaaaca atagggaaat gtttaagttc atcatggtac
ttagacttaa tggaatgtca 5640 tgccttattt acatttttaa acaggtactg
agggactcct gtctgccaag ggccgtattg 5700 agtactttcc acaacctaat
ttaatccaca ctatactgtg agattaaaaa cattcattaa 5760 aatgttgcaa
aggttctata aagctgagag acaaatatat tctataactc agcaatccca 5820
cttctagatg actgagtgtc cccacccacc aaaaaactat gcaagaatgt tcaaagcagc
5880 tttatttaca aaagccaaaa attggaaata gcccgattgt ccaacaatag
aatgagttat 5940 taaactgtgg tatgtttata cattagaata cccaatgagg
agaattaaca agctacaact 6000 atacctactc acacagatga atctcataaa
aataatgtta cataagagaa actcaatgca 6060 aaagatatgt tctgtatgtt
ttcatccata taaagttcaa aaccaggtaa aaataaagtt 6120 agaaatttgg
atggaaatta ctcttagctg ggggtgggcg agttagtgcc tgggagaaga 6180
caagaagggg cttctggggt cttggtaatg ttctgttcct cgtgtggggt tgtgcagtta
6240 tgatctgtgc actgttctgt atacacatta tgcttcaaaa taacttcaca
taaagaacat 6300 cttataccca gttaatagat agaagaggaa taagtaatag
gtcaagacca cgcagctggt 6360 aagtgggggg gcctgggatc aaatagctac
ctgcctaatc ctgccctctt gagccctgaa 6420 tgagtctgcc ttccagggct
caaggtgctc aacaaaacaa caggcctgct attttcctgg 6480 catctgtgcc
ctgtttggct agctaggagc acacatacat agaaattaaa tgaaacagac 6540
cttcagcaag gggacagagg acagaattaa ccttgcccag acactggaaa cccatgtatg
6600 aacactcaca tgtttgggaa gggggaaggg cacatgtaaa tgaggactct
tcctcattct 6660 atggggcact ctggccctgc ccctctcagc tactcatcca
tccaacacac ctttctaagt 6720 acctctctct gcctacactc tgaaggggtt
caggagtaac taacacagca tcccttccct 6780 caaatgactg acaatccctt
tgtcctgctt tgtttttctt tccagtcagt actgggaaag 6840 tggggaagga
cagtcatgga gaaactacat aaggaagcac cttgcccttc tgcctcttga 6900
gaatgttgat gagtatcaaa tctttcaaac tttggaggtt tgagtagggg tgagactcag
6960 taatgtccct tccaatgaca tgaacttgct cactcatccc tgggggccaa
attgaacaat 7020 caaaggcagg cataatccag ctatgaattc taggatcgat
ccagacatga taagatacat 7080 tgatgagttt ggacaaacca caactagaat
gcagtgaaaa aaatgcttta tttgtgaaat 7140 ttgtgatgct attgctttat
ttgtaaccat tataagctgc aataaacaag ttaacaacaa 7200 caattgcatt
cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa 7260
gtaaaacctc tacaaatgtg gtatggctga ttatgatctc tagtcaaggc actatacatc
7320 aaatattcct tattaacccc tttacaaatt aaaaagctaa aggtacacaa
tttttgagca 7380 tagttattaa tagcagacac tctatgcctg tgtggagtaa
gaaaaaacag tatgttatga 7440 ttataactgt tatgcctact tataaaggtt
acagaatatt tttccataat tttcttgtat 7500 agcagtgcag ctttttcctt
tgtggtgtaa atagcaaagc aagcaagagt tctattacta 7560 aacacagcat
gactcaaaaa acttagcaat tctgaaggaa agtccttggg gtcttctacc 7620
tttctcttct tttttggagg agtagaatgt tgagagtcag cagtagcctc atcatcacta
7680 gatggcattt cttctgagca aaacaggttt tcctcattaa aggcattcca
ccactgctcc 7740 cattcatcag ttccataggt tggaatctaa aatacacaaa
caattagaat cagtagttta 7800 acacattata cacttaaaaa ttttatattt
accttagagc tttaaatctc tgtaggtagt 7860 ttgtccaatt atgtcacacc
acagaagtaa ggttccttca caaagatccg ggaccaaagc 7920 ggccatcgtg
cctccccact cctgcagttc gggggcatgg atgcgcggat agccgctgct 7980
ggtttcctgg atgccgacgg atttgcactg ccggtagaac tccgcgaggt cgtccagcct
8040 caggcagcag ctgaaccaac tcgcgagggg atcgagcccg gggtgggcga
agaactccag 8100 catgagatcc ccgcgctgga ggatcatcca gccggcgtcc
cggaaaacga ttccgaagcc 8160 caacctttca tagaaggcgg cggtggaatc
gaaatctcgt gatggcaggt tgggcgtcgc 8220 ttggtcggtc atttcgaacc
ccagagtccc gctcagaaga actcgtcaag aaggcgatag 8280 aaggcgatgc
gctgcgaatc gggagcggcg ataccgtaaa gcacgaggaa gcggtcagcc 8340
cattcgccgc caagctcttc agcaatatca cgggtagcca acgctatgtc ctgatagcgg
8400 tccgccacac ccagccggcc acagtcgatg aatccagaaa agcggccatt
ttccaccatg 8460 atattcggca agcaggcatc gccatgggtc acgacgagat
cctcgccgtc gggcatgcgc 8520 gccttgagcc tggcgaacag ttcggctggc
gcgagcccct gatgctcttc gtccagatca 8580 tcctgatcga caagaccggc
ttccatccga gtacgtgctc gctcgatgcg atgtttcgct 8640 tggtggtcga
atgggcaggt agccggatca agcgtatgca gccgccgcat tgcatcagcc 8700
atgatggata ctttctcggc aggagcaagg tgagatgaca ggagatcctg ccccggcact
8760 tcgcccaata gcagccagtc ccttcccgct tcagtgacaa cgtcgagcac
agctgcgcaa 8820 ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct
cgtcctgcag ttcattcagg 8880 gcaccggaca ggtcggtctt gacaaaaaga
accgggcgcc cctgcgctga cagccggaac 8940 acggcggcat cagagcagcc
gattgtctgt tgtgcccagt catagccgaa tagcctctcc 9000 acccaagcgg
ccggagaacc tgcgtgcaat ccatcttgtt caatcatgcg aaacgatcct 9060
catcctgtct cttgatcaga tcttgatccc ctgcgccatc agatccttgg cggcaagaaa
9120 gccatccagt ttactttgca gggcttccca accttaccag agggcgcccc
agctggcaat 9180 tccggttcgc ttgctgtcca taaaaccgcc cagtctagct
atcgccatgt aagcccactg 9240 caagctacct gctttctctt tgcgcttgcg
ttttcccttg tccagatagc ccagtagctg 9300 acattcatcc ggggtcagca
ccgtttctgc ggactggctt tctacgtgtt ccgcttcctt 9360 tagcagccct
tgcgccctga gtgcttgcgg cagcgtgaag 9400 <210> SEQ ID NO 18
<211> LENGTH: 9362 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic expression vector <220> FEATURE:
<223> OTHER INFORMATION: Nucleotide sequence of the
expression vector HCMV-K HuAb-VL1 hum V2 (Complete DNA Sequence of
a humanised light chain expression vector comprising SEQ ID NO: 13
(humV2=VLm) from 3926-4246) <400> SEQUENCE: 18 ctagcttttt
gcaaaagcct aggcctccaa aaaagcctcc tcactacttc tggaatagct 60
cagaggccga ggcggcctcg gcctctgcat aaataaaaaa aattagtcag ccatggggcg
120 gagaatgggc ggaactgggc ggagttaggg gcgggatggg cggagttagg
ggcgggacta 180 tggttgctga ctaattgaga tgcatgcttt gcatacttct
gcctgctggg gagcctggtt 240 gctgactaat tgagatgcat gctttgcata
cttctgcctg ctggggagcc tggggacttt 300 ccacacccta actgacacac
attccacagc tgcctcgcgc gtttcggtga tgacggtgaa 360 aacctctgac
acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg 420
agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg cgcagccatg
480 acccagtcac gtagcgatag cggagtgtat actggcttaa ctatgcggca
tcagagcaga 540 ttgtactgag agtgcaccat atgcggtgtg aaataccgca
cagatgcgta aggagaaaat 600 accgcatcag gcgctcttcc gcttcctcgc
tcactgactc gctgcgctcg gtcgttcggc 660 tgcggcgagc ggtatcagct
cactcaaagg cggtaatacg gttatccaca gaatcagggg 720 ataacgcagg
aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg 780
ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac
840 gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg
tttccccctg 900 gaagctccct cgtgcgctct cctgttccga ccctgccgct
taccggatac ctgtccgcct 960 ttctcccttc gggaagcgtg gcgctttctc
atagctcacg ctgtaggtat ctcagttcgg 1020 tgtaggtcgt tcgctccaag
ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct 1080 gcgccttatc
cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac 1140
tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt
1200 tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt
atctgcgctc 1260 tgctgaagcc agttaccttc ggaaaaagag ttggtagctc
ttgatccggc aaacaaacca 1320 ccgctggtag cggtggtttt tttgtttgca
agcagcagat tacgcgcaga aaaaaaggat 1380 ctcaagaaga tcctttgatc
ttttctacgg ggtctgacgc tcagtggaac gaaaactcac 1440 gttaagggat
tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt 1500
aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc
1560 aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca
tccatagttg 1620 cctgactccc cgtcgtgtag ataactacga tacgggaggg
cttaccatct ggccccagtg 1680 ctgcaatgat accgcgagac ccacgctcac
cggctccaga tttatcagca ataaaccagc 1740 cagccggaag ggccgagcgc
agaagtggtc ctgcaacttt atccgcctcc atccagtcta 1800 ttaattgttg
ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg 1860
ttgccattgc tgcaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct
1920 ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa
aaagcggtta 1980 gctccttcgg tcctccgatc gttgtcagaa gtaagttggc
cgcagtgtta tcactcatgg 2040 ttatggcagc actgcataat tctcttactg
tcatgccatc cgtaagatgc ttttctgtga 2100 ctggtgagta ctcaaccaag
tcattctgag aatagtgtat gcggcgaccg agttgctctt 2160 gcccggcgtc
aacacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca 2220
ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt
2280 cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc
accagcgttt 2340 ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa
gggaataagg gcgacacgga 2400 aatgttgaat actcatactc ttcctttttc
aatattattg aagcatttat cagggttatt 2460 gtctcatgag cggatacata
tttgaatgta tttagaaaaa taaacaaata ggggttccgc 2520 gcacatttcc
ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa 2580
cctataaaaa taggcgtatc acgaggccct ttcgtcttca agaattcagc ttggctgcag
2640 tgaataataa aatgtgtgtt tgtccgaaat acgcgttttg agatttctgt
cgccgactaa 2700 attcatgtcg cgcgatagtg gtgtttatcg ccgatagaga
tggcgatatt ggaaaaatcg 2760 atatttgaaa atatggcata ttgaaaatgt
cgccgatgtg agtttctgtg taactgatat 2820 cgccattttt ccaaaagtga
tttttgggca tacgcgatat ctggcgatag cgcttatatc 2880 gtttacgggg
gatggcgata gacgactttg gtgacttggg cgattctgtg tgtcgcaaat 2940
atcgcagttt cgatataggt gacagacgat atgaggctat atcgccgata gaggcgacat
3000 caagctggca catggccaat gcatatcgat ctatacattg aatcaatatt
ggccattagc 3060 catattattc attggttata tagcataaat caatattggc
tattggccat tgcatacgtt 3120 gtatccatat cataatatgt acatttatat
tggctcatgt ccaacattac cgccatgttg 3180 acattgatta ttgactagtt
attaatagta atcaattacg gggtcattag ttcatagccc 3240 atatatggag
ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 3300
cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac
3360 tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg
cagtacatca 3420 agtgtatcat atgccaagta cgccccctat tgacgtcaat
gacggtaaat ggcccgcctg 3480 gcattatgcc cagtacatga ccttatggga
ctttcctact tggcagtaca tctacgtatt 3540 agtcatcgct attaccatgg
tgatgcggtt ttggcagtac atcaatgggc gtggatagcg 3600 gtttgactca
cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg 3660
gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat
3720 gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctcgtttag
tgaaccgtca 3780 gatcgcctgg agacgccatc cacgctgttt tgacctccat
agaagacacc gggaccgatc 3840 cagcctccgc aagcttgccg ccaccatgga
gacccccgcc cagctgctgt tcctgctgct 3900 gctgtggctg cccgacacca
ccggcgacat tctgctgacc cagtctccag ccaccctgtc 3960 tctgagtcca
ggagaaagag ccactttctc ctgcagggcc agtcagaaca ttggcacaag 4020
catacagtgg tatcaacaaa aaacaaatgg tgctccaagg cttctcataa ggtcttcttc
4080 tgagtctatc tctgggatcc cttccaggtt tagtggcagt ggatcaggga
cagattttac 4140 tcttaccatc agcagtctgg agcctgaaga ttttgcagtg
tattactgtc aacaaagtaa 4200 tacctggcca ttcacgttcg gccaggggac
caagctggag atcaaacgtg agtattctag 4260 aaagatccta gaattctaaa
ctctgagggg gtcggatgac gtggccattc tttgcctaaa 4320 gcattgagtt
tactgcaagg tcagaaaagc atgcaaagcc ctcagaatgg ctgcaaagag 4380
ctccaacaaa acaatttaga actttattaa ggaatagggg gaagctagga agaaactcaa
4440 aacatcaaga ttttaaatac gcttcttggt ctccttgcta taattatctg
ggataagcat 4500 gctgttttct gtctgtccct aacatgccct gtgattatcc
gcaaacaaca cacccaaggg 4560 cagaactttg ttacttaaac accatcctgt
ttgcttcttt cctcaggaac tgtggctgca 4620 ccatctgtct tcatcttccc
gccatctgat gagcagttga aatctggaac tgcctctgtt 4680 gtgtgcctgc
tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac 4740
gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc
4800 tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca
caaagtctac 4860 gcctgcgaag tcacccatca gggcctgagc tcgcccgtca
caaagagctt caacagggga 4920 gagtgttaga gggagaagtg cccccacctg
ctcctcagtt ccagcctgac cccctcccat 4980 cctttggcct ctgacccttt
ttccacaggg gacctacccc tattgcggtc ctccagctca 5040 tctttcacct
cacccccctc ctcctccttg gctttaatta tgctaatgtt ggaggagaat 5100
gaataaataa agtgaatctt tgcacctgtg gtttctctct ttcctcattt aataattatt
5160 atctgttgtt taccaactac tcaatttctc ttataaggga ctaaatatgt
agtcatccta 5220 aggcgcataa ccatttataa aaatcatcct tcattctatt
ttaccctatc atcctctgca 5280 agacagtcct ccctcaaacc cacaagcctt
ctgtcctcac agtcccctgg gccatggtag 5340 gagagacttg cttccttgtt
ttcccctcct cagcaagccc tcatagtcct ttttaagggt 5400 gacaggtctt
acagtcatat atcctttgat tcaattccct gagaatcaac caaagcaaat 5460
ttttcaaaag aagaaacctg ctataaagag aatcattcat tgcaacatga tataaaataa
5520 caacacaata aaagcaatta aataaacaaa caatagggaa atgtttaagt
tcatcatggt 5580 acttagactt aatggaatgt catgccttat ttacattttt
aaacaggtac tgagggactc 5640 ctgtctgcca agggccgtat tgagtacttt
ccacaaccta atttaatcca cactatactg 5700 tgagattaaa aacattcatt
aaaatgttgc aaaggttcta taaagctgag agacaaatat 5760 attctataac
tcagcaatcc cacttctaga tgactgagtg tccccaccca ccaaaaaact 5820
atgcaagaat gttcaaagca gctttattta caaaagccaa aaattggaaa tagcccgatt
5880 gtccaacaat agaatgagtt attaaactgt ggtatgttta tacattagaa
tacccaatga 5940 ggagaattaa caagctacaa ctatacctac tcacacagat
gaatctcata aaaataatgt 6000 tacataagag aaactcaatg caaaagatat
gttctgtatg ttttcatcca tataaagttc 6060 aaaaccaggt aaaaataaag
ttagaaattt ggatggaaat tactcttagc tgggggtggg 6120 cgagttagtg
cctgggagaa gacaagaagg ggcttctggg gtcttggtaa tgttctgttc 6180
ctcgtgtggg gttgtgcagt tatgatctgt gcactgttct gtatacacat tatgcttcaa
6240 aataacttca cataaagaac atcttatacc cagttaatag atagaagagg
aataagtaat 6300 aggtcaagac cacgcagctg gtaagtgggg gggcctggga
tcaaatagct acctgcctaa 6360 tcctgccctc ttgagccctg aatgagtctg
ccttccaggg ctcaaggtgc tcaacaaaac 6420 aacaggcctg ctattttcct
ggcatctgtg ccctgtttgg ctagctagga gcacacatac 6480 atagaaatta
aatgaaacag accttcagca aggggacaga ggacagaatt aaccttgccc 6540
agacactgga aacccatgta tgaacactca catgtttggg aagggggaag ggcacatgta
6600 aatgaggact cttcctcatt ctatggggca ctctggccct gcccctctca
gctactcatc 6660 catccaacac acctttctaa gtacctctct ctgcctacac
tctgaagggg ttcaggagta 6720 actaacacag catcccttcc ctcaaatgac
tgacaatccc tttgtcctgc tttgtttttc 6780 tttccagtca gtactgggaa
agtggggaag gacagtcatg gagaaactac ataaggaagc 6840 accttgccct
tctgcctctt gagaatgttg atgagtatca aatctttcaa actttggagg 6900
tttgagtagg ggtgagactc agtaatgtcc cttccaatga catgaacttg ctcactcatc
6960 cctgggggcc aaattgaaca atcaaaggca ggcataatcc agctatgaat
tctaggatcg 7020 atccagacat gataagatac attgatgagt ttggacaaac
cacaactaga atgcagtgaa 7080 aaaaatgctt tatttgtgaa atttgtgatg
ctattgcttt atttgtaacc attataagct 7140 gcaataaaca agttaacaac
aacaattgca ttcattttat gtttcaggtt cagggggagg 7200 tgtgggaggt
tttttaaagc aagtaaaacc tctacaaatg tggtatggct gattatgatc 7260
tctagtcaag gcactataca tcaaatattc cttattaacc cctttacaaa ttaaaaagct
7320 aaaggtacac aatttttgag catagttatt aatagcagac actctatgcc
tgtgtggagt 7380 aagaaaaaac agtatgttat gattataact gttatgccta
cttataaagg ttacagaata 7440 tttttccata attttcttgt atagcagtgc
agctttttcc tttgtggtgt aaatagcaaa 7500 gcaagcaaga gttctattac
taaacacagc atgactcaaa aaacttagca attctgaagg 7560 aaagtccttg
gggtcttcta cctttctctt cttttttgga ggagtagaat gttgagagtc 7620
agcagtagcc tcatcatcac tagatggcat ttcttctgag caaaacaggt tttcctcatt
7680 aaaggcattc caccactgct cccattcatc agttccatag gttggaatct
aaaatacaca 7740 aacaattaga atcagtagtt taacacatta tacacttaaa
aattttatat ttaccttaga 7800 gctttaaatc tctgtaggta gtttgtccaa
ttatgtcaca ccacagaagt aaggttcctt 7860 cacaaagatc cgggaccaaa
gcggccatcg tgcctcccca ctcctgcagt tcgggggcat 7920 ggatgcgcgg
atagccgctg ctggtttcct ggatgccgac ggatttgcac tgccggtaga 7980
actccgcgag gtcgtccagc ctcaggcagc agctgaacca actcgcgagg ggatcgagcc
8040 cggggtgggc gaagaactcc agcatgagat ccccgcgctg gaggatcatc
cagccggcgt 8100 cccggaaaac gattccgaag cccaaccttt catagaaggc
ggcggtggaa tcgaaatctc 8160 gtgatggcag gttgggcgtc gcttggtcgg
tcatttcgaa ccccagagtc ccgctcagaa 8220 gaactcgtca agaaggcgat
agaaggcgat gcgctgcgaa tcgggagcgg cgataccgta 8280 aagcacgagg
aagcggtcag cccattcgcc gccaagctct tcagcaatat cacgggtagc 8340
caacgctatg tcctgatagc ggtccgccac acccagccgg ccacagtcga tgaatccaga
8400 aaagcggcca ttttccacca tgatattcgg caagcaggca tcgccatggg
tcacgacgag 8460 atcctcgccg tcgggcatgc gcgccttgag cctggcgaac
agttcggctg gcgcgagccc 8520 ctgatgctct tcgtccagat catcctgatc
gacaagaccg gcttccatcc gagtacgtgc 8580 tcgctcgatg cgatgtttcg
cttggtggtc gaatgggcag gtagccggat caagcgtatg 8640 cagccgccgc
attgcatcag ccatgatgga tactttctcg gcaggagcaa ggtgagatga 8700
caggagatcc tgccccggca cttcgcccaa tagcagccag tcccttcccg cttcagtgac
8760 aacgtcgagc acagctgcgc aaggaacgcc cgtcgtggcc agccacgata
gccgcgctgc 8820 ctcgtcctgc agttcattca gggcaccgga caggtcggtc
ttgacaaaaa gaaccgggcg 8880 cccctgcgct gacagccgga acacggcggc
atcagagcag ccgattgtct gttgtgccca 8940 gtcatagccg aatagcctct
ccacccaagc ggccggagaa cctgcgtgca atccatcttg 9000 ttcaatcatg
cgaaacgatc ctcatcctgt ctcttgatca gatcttgatc ccctgcgcca 9060
tcagatcctt ggcggcaaga aagccatcca gtttactttg cagggcttcc caaccttacc
9120 agagggcgcc ccagctggca attccggttc gcttgctgtc cataaaaccg
cccagtctag 9180 ctatcgccat gtaagcccac tgcaagctac ctgctttctc
tttgcgcttg cgttttccct 9240 tgtccagata gcccagtagc tgacattcat
ccggggtcag caccgtttct gcggactggc 9300 tttctacgtg ttccgcttcc
tttagcagcc cttgcgccct gagtgcttgc ggcagcgtga 9360 ag 9362
<210> SEQ ID NO 19 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric murine-human construct
<220> FEATURE: <223> OTHER INFORMATION: hypervariable
regions CDR1' in a CD45RO/RB binding molecule of SEQ ID NO:1
<400> SEQUENCE: 19 Arg Ala Ser Gln Asn Ile Gly Thr Ser Ile
Gln 1 5 10 <210> SEQ ID NO 20 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: chimeric murine-human
construct <220> FEATURE: <223> OTHER INFORMATION:
hypervariable region CDR2' in a CD45RO/RB binding molecule of SEQ
ID NO:1 <400> SEQUENCE: 20 Ser Ser Ser Glu Ser Ile Ser 1 5
<210> SEQ ID NO 21 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric murine-human construct
<220> FEATURE: <223> OTHER INFORMATION: hypervariable
region CDR3' in a CD45RO/RB binding molecule of SEQ ID NO:1
<400> SEQUENCE: 21 Gln Gln Ser Asn Thr Trp Pro Phe Thr 1 5
<210> SEQ ID NO 22 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric murine-human construct
<220> FEATURE: <223> OTHER INFORMATION: hypervariable
region CDR1 in a CD45RO/RB binding molecule of SEQ ID NO:2
<400> SEQUENCE: 22 Asn Tyr Ile Ile His 1 5 <210> SEQ ID
NO 23 <211> LENGTH: 17 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: chimeric murine-human construct <220> FEATURE:
<223> OTHER INFORMATION: hypervariable region CDR2 in a
CD45RO/RB binding molecule of SEQ ID NO:2 <400> SEQUENCE: 23
Tyr Phe Asn Pro Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe Lys 1 5
10 15 Gly <210> SEQ ID NO 24 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: chimeric murine-human
construct <220> FEATURE: <223> OTHER INFORMATION:
hypervariable region CDR3 in a CD45RO/RB binding molecule of SEQ ID
NO:2 <400> SEQUENCE: 24 Ser Gly Pro Tyr Ala Trp Phe Asp Thr 1
5 <210> SEQ ID NO 25 <211> LENGTH: 33 <212> TYPE:
DNA <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric murine-human construct
<220> FEATURE: <223> OTHER INFORMATION: polynucleotide
sequence encoding the amino acid sequence of CDR1 <400>
SEQUENCE: 25 ggccagtcag aacattggca caagcataca gtg 33 <210>
SEQ ID NO 26 <211> LENGTH: 21 <212> TYPE: DNA
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: chimeric murine-human construct <220>
FEATURE: <223> OTHER INFORMATION: polynucleotide sequence
encoding the amino acid sequence of CDR2 <400> SEQUENCE: 26
ttcttctgag tctatctctg g 21 <210> SEQ ID NO 27 <211>
LENGTH: 27 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
murine-human construct <220> FEATURE: <223> OTHER
INFORMATION: polynucleotide sequence encoding the amino acid
sequence of CDR3 <400> SEQUENCE: 27 acaaagtaat acctggccat
tcacgtt 27 <210> SEQ ID NO 28 <211> LENGTH: 15
<212> TYPE: DNA <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: chimeric murine-human
construct <220> FEATURE: <223> OTHER INFORMATION:
polynucleotide sequence encoding the amino acid sequence of CDR1'
<400> SEQUENCE: 28 ttatattatc cactg 15 <210> SEQ ID NO
29 <211> LENGTH: 51 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: chimeric murine-human construct <220> FEATURE:
<223> OTHER INFORMATION: polynucleotide sequence encoding the
amino acid sequence of CDR2' <400> SEQUENCE: 29 ttttaatcct
tacaatcatg gtactaagta caatgagaag ttcaaaggca g 51 <210> SEQ ID
NO 30 <211> LENGTH: 27 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: chimeric murine-human construct <220> FEATURE:
<223> OTHER INFORMATION: polynucleotide sequence encoding the
amino acid sequence of CDR3' <400> SEQUENCE: 30 aggaccctat
gcctggtttg acacctg 27 <210> SEQ ID NO 31 <211> LENGTH:
118 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
murine-human construct <220> FEATURE: <223> OTHER
INFORMATION: Part of amino acid sequence of humanised heavy chain
designated VHE-N73D <400> SEQUENCE: 31 Glu Val Gln Leu Val
Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ile
Ile His Trp Val Lys Gln Glu Pro Gly Gln Gly Leu Glu Trp Ile 35 40
45 Gly Tyr Phe Asn Pro Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60 Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ile Ser Thr
Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp
Thr Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115
<210> SEQ ID NO 32 <211> LENGTH: 118 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric murine-human construct
<220> FEATURE: <223> OTHER INFORMATION: Part of amino
acid sequence of humanised heavy chain designated VHQ-N73D
<400> SEQUENCE: 32 Gln Val Gln Leu Val Glu Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ile Ile His Trp Val Lys
Gln Glu Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe Asn
Pro Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Gly
Arg Ala Thr Leu Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp Gly Gln Gly
Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> SEQ ID NO
33 <211> LENGTH: 321 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: chimeric murine-human construct <220> FEATURE:
<223> OTHER INFORMATION: Nucleotide sequence encoding amino
acid sequence SEQ ID NO: 8 <400> SEQUENCE: 33 gacattctgc
tgacccagtc tccagccacc ctgtctctga gtccaggaga aagagccact 60
ctctcctgca gggccagtca gaacattggc acaagcatac agtggtatca acaaaaacca
120 ggtcaggctc caaggcttct cataaggtct tcttctgagt ctatctctgg
gatcccttcc 180 aggtttagtg gcagtggatc agggacagat tttactctta
ccatcagcag tctggagcct 240 gaagattttg cagtgtatta ctgtcaacaa
agtaatacct ggccattcac gttcggccag 300 gggaccaagc ttgaaatcaa a 321
<210> SEQ ID NO 34 <211> LENGTH: 354 <212> TYPE:
DNA <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric murine-human construct
<220> FEATURE: <223> OTHER INFORMATION: Nucleotide
sequence encoding amino acid sequence SEQ ID NO: 31 <400>
SEQUENCE: 34 gaggtgcagc tggtggagtc aggagccgaa gtgaaaaagc ctggggcttc
agtgaaggtg 60 tcctgcaagg cctctggata cacattcact aattatatta
tccactgggt gaagcaggag 120 cctggtcagg gccttgaatg gattggatat
tttaatcctt acaatcatgg tactaagtac 180 aatgagaagt tcaaaggcag
ggccacacta actgcagaca aatccatcag cacagcctac 240 atggagctca
gcagcctgcg ctctgaggac actgcggtct actactgtgc aagatcagga 300
ccctatgcct ggtttgacac ctggggccaa gggaccacgg tcaccgtctc ctca 354
<210> SEQ ID NO 35 <211> LENGTH: 354 <212> TYPE:
DNA <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric murine-human construct
<220> FEATURE: <223> OTHER INFORMATION: Nucleotide
sequence encoding amino acid sequence SEQ ID NO: 32 <400>
SEQUENCE: 35 caggtgcagc tggtggagtc aggagccgaa gtgaaaaagc ctggggcttc
agtgaaggtg 60 tcctgcaagg cctctggata cacattcact aattatatta
tccactgggt gaagcaggag 120 cctggtcagg gccttgaatg gattggatat
tttaatcctt acaatcatgg tactaagtac 180 aatgagaagt tcaaaggcag
ggccacacta actgcagaca aatccatcag cacagcctac 240 atggagctca
gcagcctgcg ctctgaggac actgcggtct actactgtgc aagatcagga 300
ccctatgcct ggtttgacac ctggggccaa gggaccacgg tcaccgtctc ctca 354
<210> SEQ ID NO 36 <211> LENGTH: 8096 <212> TYPE:
DNA <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: synthetic expression vector
<220> FEATURE: <223> OTHER INFORMATION: Nucleotide
sequence of expression vector LCVL1Sp20 <400> SEQUENCE: 36
ctagagtcct agagaggtct ggtggagcct gcaaaagtcc agctttcaaa ggaacacaga
60 agtatgtgta tggaatatta gaagatgttg cttttactct taagttggtt
cctaggaaaa 120 atagttaaat actgtgactt taaaatgtga gagggttttc
aagtactcat ttttttaaat 180 gtccaaaatt tttgtcaatc aatttgaggt
cttgtttgtg tagaactgac attacttaaa 240 gtttaaccga ggaatgggag
tgaggctctc tcatacccta ttcagaactg acttttaaca 300 ataataaatt
aagtttaaaa tatttttaaa tgaattgagc aatgttgagt tggagtcaag 360
atggccgatc agaaccagaa cacctgcagc agctggcagg aagcaggtca tgtggcaagg
420 ctatttgggg aagggaaaat aaaaccacta ggtaaacttg tagctgtggt
ttgaagaagt 480 ggttttgaaa cactctgtcc agccccacca aaccgaaagt
ccaggctgag caaaacacca 540 cctgggtaat ttgcatttct aaaataagtt
gaggattcag ccgaaactgg agaggtcctc 600 ttttaactta ttgagttcaa
ccttttaatt ttagcttgag tagttctagt ttccccaaac 660 ttaagtttat
cgacttctaa aatgtattta gaactcattt tcaaaattag gttatgtaag 720
aaattgaagg actttagtgt ctttaatttc taatatattt agaaaacttc ttaaaattac
780 tctattattc ttccctctga ttattggtct ccattcaatt cttttccaat
acccgaagca 840 tttacagtga ctttgttcat gatctttttt agttgtttgt
tttgccttac tattaagact 900 ttgacattct ggtcaaaacg gcttcacaaa
tctttttcaa gaccactttc tgagtattca 960 ttttaggaga aatacttttt
ttttaaatga atgcaattat ctaggacctg caggcatgct 1020 gttttctgtc
tgtccctaac atgccctgtg attatccgca aacaacacac ccaagggcag 1080
aactttgtta cttaaacacc atcctgtttg cttctttcct caggaactgt ggctgcacca
1140 tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc
ctctgttgtg 1200 tgcctgctga ataacttcta tcccagagag gccaaagtac
agtggaaggt ggataacgcc 1260 ctccaatcgg gtaactccca ggagagtgtc
acagagcagg acagcaagga cagcacctac 1320 agcctcagca gcaccctgac
gctgagcaaa gcagactacg agaaacacaa agtctacgcc 1380 tgcgaagtca
cccatcaggg cctgagctcg cccgtcacaa agagcttcaa caggggagag 1440
tgttagaggg agaagtgccc ccacctgctc ctcagttcca gcctgacccc ctcccatcct
1500 ttggcctctg accctttttc cacaggggac ctacccctat tgcggtcctc
cagctcatct 1560 ttcacctcac ccccctcctc ctccttggct ttaattatgc
taatgttgga ggagaatgaa 1620 taaataaagt gaatctttgc acctgtggtt
tctctctttc ctcatttaat aattattatc 1680 tgttgtttta ccaactactc
aatttctctt ataagggact aaatatgtag tcatcctaag 1740 gcgggatatc
gagatctgaa gctgatccag acatgataag atacattgat gagtttggac 1800
aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt gatgctattg
1860 ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat
tgcattcatt 1920 ttatgtttca ggttcagggg gaggtgtggg aggtttttta
aagcaagtaa aacctctaca 1980 aatgtggtat ggctgattat gatctctagt
caaggcacta tacatcaaat attccttatt 2040 aaccccttta caaattaaaa
agctaaaggt acacaatttt tgagcatagt tattaatagc 2100 agacactcta
tgcctgtgtg gagtaagaaa aaacagtatg ttatgattat aactgttatg 2160
cctacttata aaggttacag aatatttttc cataattttc ttgtatagca gtgcagcttt
2220 ttcctttgtg gtgtaaatag caaagcaagc aagagttcta ttactaaaca
cagcatgact 2280 caaaaaactt agcaattctg aaggaaagtc cttggggtct
tctacctttc tcttcttttt 2340 tggaggagta gaatgttgag agtcagcagt
agcctcatca tcactagatg gcatttcttc 2400 tgagcaaaac aggttttcct
cattaaaggc attccaccac tgctcccatt catcagttcc 2460 ataggttgga
atctaaaata cacaaacaat tagaatcagt agtttaacac attatacact 2520
taaaaatttt atatttacct tagagcttta aatctctgta ggtagtttgt ccaattatgt
2580 cacaccacag aagtaaggtt ccttcacaaa gatccggacc aaagcggcca
tcgtgcctcc 2640 ccactcctgc agttcggggg catggatgcg cggatagccg
ctgctggttt cctggatgcc 2700 gacggatttg cactgccggt agaactccgc
gaggtcgtcc agcctcaggc agcagctgaa 2760 ccaactcgcg aggggatcga
gcatccccca tggtcttata aaaatgcata gctttaggag 2820 gggagcagag
aacttgaaag catcttcctg ttagtctttc ttctcgtaga cttcaaactt 2880
atacttgatg cctttttcct cctggacctc agagaggacg cctgggtatt ctgggagaag
2940 tttatatttc cccaaatcaa tttctgggaa aaacgtgtca ctttcaaatt
cctgcatgat 3000 ccttgtcaca aagagtctga ggtggcctgg ttgattcatg
gcttcctggt aaacagaact 3060 gcctccgact atccaaacca tgtctacttt
acttgccaat tccggttgtt caataagtct 3120 taaggcatca tccaaacttt
tggcaagaaa atgagctcct cgtggtggtt ctttgagttc 3180 tctactgaga
actatattaa ttctgtcctt taaaggtcga ttcttctcag gaatggagaa 3240
ccaggttttc ctacccataa tcaccagatt ctgtttacct tccactgaag aggttgtggt
3300 cattctttgg aagtacttga actcgttcct gagcggaggc cagggtcggt
ctccgttctt 3360 gccaatcccc atattttggg acacggcgac gatgcagttc
aatggtcgaa ccatgatggc 3420 agcggggata aaatcctacc agccttcacg
ctaggattgc cgtcaagttt gggggtaccg 3480 agctcgaatt agctttttgc
aaaagcctag gcctccaaaa aagcctcctc actacttctg 3540 gaatagctca
gagggccgag gcggcctcgg cctctgcata aataaaaaaa attagtcagc 3600
catggggcgg agaatgggcg gaactgggcg gagttagggg cgggatgggc ggagttaggg
3660 gcgggactat ggttgctgac taattgagat gcatgctttg catacttctg
cctgctgggg 3720 agcctgggga ctttccacac ctggttgctg actaattgag
atgcatgctt tgcatacttc 3780 tgcctgctgg ggagcctggg gactttccac
accctaactg acacacattc cacagctgcc 3840 tcgcgcgttt cggtgatgac
ggtgaaaacc tctgacacat gcagctcccg gagacggtca 3900 cagcttgtct
gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg 3960
ttggcgggtg tcggggcgca gccatgaccc agtcacgtag cgatagcgga gtgtatactg
4020 gcttaactat gcggcatcag agcagattgt actgagagtg caccatatgc
ggccgcatat 4080 gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac
cgcatcaggc gctcttccgc 4140 ttcctcgctc actgactcgc tgcgctcggt
cgttcggctg cggcgagcgg tatcagctca 4200 ctcaaaggcg gtaatacggt
tatccacaga atcaggggat aacgcaggaa agaacatgtg 4260 agcaaaaggc
cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca 4320
taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa
4380 cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg
tgcgctctcc 4440 tgttccgacc ctgccgctta ccggatacct gtccgccttt
ctcccttcgg gaagcgtggc 4500 gctttctcat agctcacgct gtaggtatct
cagttcggtg taggtcgttc gctccaagct 4560 gggctgtgtg cacgaacccc
ccgttcagcc cgaccgctgc gccttatccg gtaactatcg 4620 tcttgagtcc
aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag 4680
gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta
4740 cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag
ttaccttcgg 4800 aaaaagagtt ggtagctctt gatccggcaa acaaaccacc
gctggtagcg gtggtttttt 4860 tgtttgcaag cagcagatta cgcgcagaaa
aaaaggatct caagaagatc ctttgatctt 4920 ttctacgggg tctgacgctc
agtggaacga aaactcacgt taagggattt tggtcatgag 4980 attatcaaaa
aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat 5040
ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc
5100 tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg
tcgtgtagat 5160 aactacgata cgggagggct taccatctgg ccccagtgct
gcaatgatac cgcgagaccc 5220 acgctcaccg gctccagatt tatcagcaat
aaaccagcca gccggaaggg ccgagcgcag 5280 aagtggtcct gcaactttat
ccgcctccat ccagtctatt aattgttgcc gggaagctag 5340 agtaagtagt
tcgccagtta atagtttgcg caacgttgtt gccattgctg caggcatcgt 5400
ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg
5460 agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc
ctccgatcgt 5520 tgtcagaagt aagttggccg cagtgttatc actcatggtt
atggcagcac tgcataattc 5580 tcttactgtc atgccatccg taagatgctt
ttctgtgact ggtgagtact caaccaagtc 5640 attctgagaa tagtgtatgc
ggcgaccgag ttgctcttgc ccggcgtcaa cacgggataa 5700 taccgcgcca
catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg 5760
aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc
5820 caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa
aaacaggaag 5880 gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa
tgttgaatac tcatactctt 5940 cctttttcaa tattattgaa gcatttatca
gggttattgt ctcatgagcg gatacatatt 6000 tgaatgtatt tagaaaaata
aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc 6060 acctgacgtc
taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac 6120
gaggcccttt cgtcttcaag aattcagctg ctcgaggaag agctcaaacc catgctactc
6180 tctggcttga tggaagcaac gctttcatag ctgagctgtc ataaataata
aagagatttt 6240 tttattaata ttgaaaagat gggttattta tgtaagactc
tgtcttcatt ttaaaaacca 6300 caccttccag tagtattctg ttactgttct
ggcaatcact gtgatcaaga agctacacgg 6360 tgagttgtgc ttctcagtcc
taagggatac atctacaaga ggctcccata ctcgaagctc 6420 aggaaacatt
gtagaaaagg aggcaaaaga ctgacagagc cagaggacca agaaatttgt 6480
tgtgaggttg tgtctcctac taacaatata agcaatatct ataaattgtt gatatcatgg
6540 ctactaaaat gtgagttgaa cgaggaggac acaaatgaac atgacaatca
gaatgaggcc 6600 tctcacctgc aaaaaacact atagagaagc agataaagct
gtcagcagaa gaggcgcacc 6660 tccttataga agaagcctac caggtttgat
atatcagcct tgaaaaccta catagtattt 6720 acattatatc gagtctatga
gacatattta gtaatgcata tgtatgtgtg tgtgtgcatg 6780 tatgtgtgta
aatacatatg ttcatagaaa aatgtgtaaa aagagatcat gaatttaaga 6840
gagaactggg acaatttttt tcagggagtt gtaatcagga aagttaaggg aaaaatgttg
6900 taattaaaat tcaggctcag aaacaaacaa aggaaaagaa aaaaaaacaa
caacaacaac 6960 aaaaaaacaa aacaaaggag aagctgtatg gccacaatag
catctacagc taactgtgaa 7020 aggataatgg aacaagttat gtactgccta
gagcagtatg atgcctaaat catctcgaca 7080 tggaggaaaa tagaacaaag
acactctaca tagactatga tagaaatcaa aataaggtgt 7140 aagacataga
acattagttt tgtttgttgt tcaaagagac tcacattccc acaaaaaaat 7200
ctgtgggatt ttacaggtct gcaataagct gctgacctga tgatttctgc agctgtgcct
7260 accctttgct gatttgcatg tacccaaagc atagcttact gacatgagga
tttcttcata 7320 gtcaggtcac accctttgct ggagtcagaa tcacactgat
cacacacagt catgagtgtg 7380 ctcactcagg tcctggcgtt gctgctgctg
tggcttacag gtaatgaaga cagcactaga 7440 attttattga gcttcctgta
cactgtgctg cttgtctctg tgaaaattct cttgtgaatt 7500 aatcatgtgg
ggatctgttt tcaatttttc aattgtaggt acgcgttgtg acattctgct 7560
gacccagtct ccagccaccc tgtctctgag tccaggagaa agagccactc tctcctgcag
7620 ggccagtcag aacattggca caagcataca gtggtatcaa caaaaaccag
gtcaggctcc 7680 aaggcttctc ataaggtctt cttctgagtc tatctctggg
atcccttcca ggtttagtgg 7740 cagtggatca gggacagatt ttactcttac
catcagcagt ctggagcctg aagattttgc 7800 agtgtattac tgtcaacaaa
gtaatacctg gccattcacg ttcggccagg ggaccaagct 7860 tgaaatcaaa
cgtaagtaga atccaaagtc tctttcttcc gttgtctatg tctgtggctt 7920
ctatgtctaa aaatgatgta taaaatctta ctctgaaacc agattctggc actctccaag
7980 gcaaagatac agagtaactc cgtaagcaaa gctgggaata ggctagacat
gttctctgga 8040 gaatgaatgc cagtgtaata attaacacaa gtgatagttt
cagaaatgct ctagtt 8096 <210> SEQ ID NO 37 <211> LENGTH:
11563 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: synthetic
expression vector <220> FEATURE: <223> OTHER
INFORMATION: Nucleotide sequence of the expression vector
HCVHEN73DSp20 <400> SEQUENCE: 37 ctagagaggt ctggtggagc
ctgcaaaagt ccagctttca aaggaacaca gaagtatgtg 60 tatggaatat
tagaagatgt tgcttttact cttaagttgg ttcctaggaa aaatagttaa 120
atactgtgac tttaaaatgt gagagggttt tcaagtactc atttttttaa atgtccaaaa
180 tttttgtcaa tcaatttgag gtcttgtttg tgtagaactg acattactta
aagtttaacc 240 gaggaatggg agtgaggctc tctcataccc tattcagaac
tgacttttaa caataataaa 300 ttaagtttaa aatattttta aatgaattga
gcaatgttga gttggagtca agatggccga 360 tcagaaccag aacacctgca
gcagctggca ggaagcaggt catgtggcaa ggctatttgg 420 ggaagggaaa
ataaaaccac taggtaaact tgtagctgtg gtttgaagaa gtggttttga 480
aacactctgt ccagccccac caaaccgaaa gtccaggctg agcaaaacac cacctgggta
540 atttgcattt ctaaaataag ttgaggattc agccgaaact ggagaggtcc
tcttttaact 600 tattgagttc aaccttttaa ttttagcttg agtagttcta
gtttccccaa acttaagttt 660 atcgacttct aaaatgtatt taagctttct
ggggcaggcc aggcctgacc ttggctttgg 720 ggcagggagg gggctaaggt
gaggcaggtg gcgccagcca ggtgcacacc caatgcccat 780 gagcccagac
actggacgct gaacctcgcg gacagttaag aacccagggg cctctgcgcc 840
ctgggcccag ctctgtccca caccgcggtc acatggcacc acctctcttg cagcctccac
900 caagggccca tcggtcttcc ccctggcacc ctcctccaag agcacctctg
ggggcacagc 960 ggccctgggc tgcctggtca aggactactt ccccgaaccg
gtgacggtgt cgtggaactc 1020 aggcgccctg accagcggcg tgcacacctt
cccggctgtc ctacagtcct caggactcta 1080 ctccctcagc agcgtggtga
ccgtgccctc cagcagcttg ggcacccaga cctacatctg 1140 caacgtgaat
cacaagccca gcaacaccaa ggtggacaag agagttggtg agaggccagc 1200
acagggaggg agggtgtctg ctggaagcca ggctcagcgc tcctgcctgg acgcatcccg
1260 gctatgcagt cccagtccag ggcagcaagg caggccccgt ctgcctcttc
acccggaggc 1320 ctctgcccgc cccactcatg ctcagggaga gggtcttctg
gctttttccc caggctctgg 1380 gcaggcacag gctaggtgcc cctaacccag
gccctgcaca caaaggggca ggtgctgggc 1440 tcagacctgc caagagccat
atccgggagg accctgcccc tgacctaagc ccaccccaaa 1500 ggccaaactc
tccactccct cagctcggac accttctctc ctcccagatt ccagtaactc 1560
ccaatcttct ctctgcagag cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc
1620 caggtaagcc agcccaggcc tcgccctcca gctcaaggcg ggacaggtgc
cctagagtag 1680 cctgcatcca gggacaggcc ccagccgggt gctgacacgt
ccacctccat ctcttcctca 1740 gcacctgaac tcctgggggg accgtcagtc
ttcctcttcc ccccaaaacc caaggacacc 1800 ctcatgatct cccggacccc
tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 1860 cctgaggtca
agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag 1920
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac
1980 caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc
cctcccagcc 2040 cccatcgaga aaaccatctc caaagccaaa ggtgggaccc
gtggggtgcg agggccacat 2100 ggacagaggc cggctcggcc caccctctgc
cctgagagtg accgctgtac caacctctgt 2160 ccctacaggg cagccccgag
aaccacaggt gtacaccctg cccccatccc gggaggagat 2220 gaccaagaac
caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc 2280
cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct
2340 ggactccgac ggctccttct tcctctatag caagctcacc gtggacaaga
gcaggtggca 2400 gcaggggaac gtcttctcat gctccgtgat gcatgaggct
ctgcacaacc actacacgca 2460 gaagagcctc tccctgtccc cgggtaaatg
agtgcgacgg ccggcaagcc cccgctcccc 2520 gggctctcgc ggtcgcacga
ggatgcttgg cacgtacccc gtctacatac ttcccaggca 2580 cccagcatgg
aaataaagca cccaccactg ccctgggccc ctgcgagact gtgatggttc 2640
tttccacggg tcaggccgag tctgaggcct gagtggcatg agggaggcag agcgggtccc
2700 actgtcccca cactggccca ggctgtgcag gtgtgcctgg gccgcctagg
gtggggctca 2760 gccaggggct gccctcggca gggtggggga tttgccagcg
tggccctccc tccagcagca 2820 gctgccctgg gctgggccac gagaagccct
aggagcccct ggggacagac acacagcccc 2880 tgcctctgta ggagactgtc
ctgtcctgtg agcgccctgt cctccgaccc cgatgcccac 2940 tcgggggcat
gcctagtcca tgcgcgtagg gacaggccct ccctcaccca tctaccccca 3000
cggcactaac ccctggcagc cctgcccagc ctcgcacccg catggggaca caaccgactc
3060 cggggacatg cactctcggg ccctgtggag ggactggtgc agatgcccac
acacacactc 3120 agcccagacc cgttcaacaa accccgcact gaggttggtc
gagcgggagt gcggccagag 3180 cctgcctcgg ccgtcaggga ggactcccgg
gctcactcga aggaggtgcc accatttcag 3240 ctttggtagc ttttcttctt
cttttaaatt ttctaaagct cattaattgt ctttgatgtt 3300 tcttttgtga
tgacaataaa atatcctttt taagtcttgt acttcgtgat gggagccgcc 3360
ttcctgtgtc cacgcgcctc ctgcccccgg tgggaagcac ggtcaggagg aggctggtcc
3420 agctgcacct cgggggctcc ctgcactcgc cccccgcctc ctgcagccac
acgcattgcc 3480 cgagcgaccc tccctggccc ctgtcactac atggacccct
ggggcttctc ctcttttcta 3540 catggatgca gtttctcctc ctgctgggca
cggtgctgcc tgccctggtc actctgcggg 3600 ggacagggcc tccagggaaa
gctgggtcga ggctgggagc tggctcaggc tggccaggca 3660 gagccacagg
gagggccttc cagaaccaac catggtccga agcgagaggt gggtgtcaga 3720
tccagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa
3780 aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca
ttataagctg 3840 caataaacaa gttaacaaca acaattgcat tcattttatg
tttcaggttc agggggaggt 3900 gtgggaggtt ttttaaagca agtaaaacct
ctacaaatgt ggtatggctg attatgatct 3960 ctagtcaagg cactatacat
caaatattcc ttattaaccc ctttacaaat taaaaagcta 4020 aaggtacaca
atttttgagc atagttatta atagcagaca ctctatgcct gtgtggagta 4080
agaaaaaaca gtatgttatg attataactg ttatgcctac ttataaaggt tacagaatat
4140 ttttccataa ttttcttgta tagcagtgca gctttttcct ttgtggtgta
aatagcaaag 4200 caagcaagag ttctattact aaacacagca tgactcaaaa
aacttagcaa ttctgaagga 4260 aagtccttgg ggtcttctac ctttctcttc
ttttttggag gagtagaatg ttgagagtca 4320 gcagtagcct catcatcact
agatggcatt tcttctgagc aaaacaggtt ttcctcatta 4380 aaggcattcc
accactgctc ccattcatca gttccatagg ttggaatcta aaatacacaa 4440
acaattagaa tcagtagttt aacacattat acacttaaaa attttatatt taccttagag
4500 ctttaaatct ctgtaggtag tttgtccaat tatgtcacac cacagaagta
aggttccttc 4560 acaaagatcc ggaccaaagc ggccatcgtg cctccccact
cctgcagttc gggggcatgg 4620 atgcgcggat agccgctgct ggtttcctgg
atgccgacgg atttgcactg ccggtagaac 4680 tccgcgaggt cgtccagcct
caggcagcag ctgaaccaac tcgcgagggg atcgagcccg 4740 gggtgggcga
agaactccag catgagatcc ccgcgctgga ggatcatcca gccggcgtcc 4800
cggaaaacga ttccgaagcc caacctttca tagaaggcgg cggtggaatc gaaatctcgt
4860 gatggcaggt tgggcgtcgc ttggtcggtc atttcgaacc ccagagtccc
gctcagaaga 4920 actcgtcaag aaggcgatag aaggcgatgc gctgcgaatc
gggagcggcg ataccgtaaa 4980 gcacgaggaa gcggtcagcc cattcgccgc
caagctcttc agcaatatca cgggtagcca 5040 acgctatgtc ctgatagcgg
tccgccacac ccagccggcc acagtcgatg aatccagaaa 5100 agcggccatt
ttccaccatg atattcggca agcaggcatc gccatgggtc acgacgagat 5160
cctcgccgtc gggcatgcgc gccttgagcc tggcgaacag ttcggctggc gcgagcccct
5220 gatgctcttc gtccagatca tcctgatcga caagaccggc ttccatccga
gtacgtgctc 5280 gctcgatgcg atgtttcgct tggtggtcga atgggcaggt
agccggatca agcgtatgca 5340 gccgccgcat tgcatcagcc atgatggata
ctttctcggc aggagcaagg tgagatgaca 5400 ggagatcctg ccccggcact
tcgcccaata gcagccagtc ccttcccgct tcagtgacaa 5460 cgtcgagcac
agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct 5520
cgtcctgcag ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc
5580 cctgcgctga cagccggaac acggcggcat cagagcagcc gattgtctgt
tgtgcccagt 5640 catagccgaa tagcctctcc acccaagcgg ccggagaacc
tgcgtgcaat ccatcttgtt 5700 caatcatgcg aaacgatcct catcctgtct
cttgatcaga tcttgatccc ctgcgccatc 5760 agatccttgg cggcaagaaa
gccatccagt ttactttgca gggcttccca accttaccag 5820 agggcgcccc
agctggcaat tccggttcgc ttgctgtcca taaaaccgcc cagtctagct 5880
atcgccatgt aagcccactg caagctacct gctttctctt tgcgcttgcg ttttcccttg
5940 tccagatagc ccagtagctg acattcatcc ggggtcagca ccgtttctgc
ggactggctt 6000 tctacgtgtt ccgcttcctt tagcagccct tgcgccctga
gtgcttgcgg cagcgtgaag 6060 ctttttgcaa aagcctaggc ctccaaaaaa
gcctcctcac tacttctgga atagctcaga 6120 ggccgaggcg gcctcggcct
ctgcataaat aaaaaaaatt agtcagccat ggggcggaga 6180 atgggcggaa
ctgggcggag ttaggggcgg gatgggcgga gttaggggcg ggactatggt 6240
tgctgactaa ttgagatgca tgctttgcat acttctgcct gctggggagc ctggggactt
6300 tccacacctg gttgctgact aattgagatg catgctttgc atacttctgc
ctgctgggga 6360 gcctggggac tttccacacc ctaactgaca cacattccac
agctgcctcg cgcgtttcgg 6420 tgatgacggt gaaaacctct gacacatgca
gctcccggag acggtcacag cttgtctgta 6480 agcggatgcc gggagcagac
aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg 6540 gggcgcagcc
atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg 6600
gcatcagagc agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc
6660 gtaaggagaa aataccgcat caggcgctct tccgcttcct cgctcactga
ctcgctgcgc 6720 tcggtcgttc ggctgcggcg agcggtatca gctcactcaa
aggcggtaat acggttatcc 6780 acagaatcag gggataacgc aggaaagaac
atgtgagcaa aaggccagca aaaggccagg 6840 aaccgtaaaa aggccgcgtt
gctggcgttt ttccataggc tccgcccccc tgacgagcat 6900 cacaaaaatc
gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag 6960
gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga
7020 tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc
acgctgtagg 7080 tatctcagtt cggtgtaggt cgttcgctcc aagctgggct
gtgtgcacga accccccgtt 7140 cagcccgacc gctgcgcctt atccggtaac
tatcgtcttg agtccaaccc ggtaagacac 7200 gacttatcgc cactggcagc
agccactggt aacaggatta gcagagcgag gtatgtaggc 7260 ggtgctacag
agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt 7320
ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc
7380 ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca
gattacgcgc 7440 agaaaaaaag gatctcaaga agatcctttg atcttttcta
cggggtctga cgctcagtgg 7500 aacgaaaact cacgttaagg gattttggtc
atgagattat caaaaaggat cttcacctag 7560 atccttttaa attaaaaatg
aagttttaaa tcaatctaaa gtatatatga gtaaacttgg 7620 tctgacagtt
accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt 7680
tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca
7740 tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc
agatttatca 7800 gcaataaacc agccagccgg aagggccgag cgcagaagtg
gtcctgcaac tttatccgcc 7860 tccatccagt ctattaattg ttgccgggaa
gctagagtaa gtagttcgcc agttaatagt 7920 ttgcgcaacg ttgttgccat
tgctgcaggc atcgtggtgt cacgctcgtc gtttggtatg 7980 gcttcattca
gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc 8040
aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg
8100 ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc
atccgtaaga 8160 tgcttttctg tgactggtga gtactcaacc aagtcattct
gagaatagtg tatgcggcga 8220 ccgagttgct cttgcccggc gtcaacacgg
gataataccg cgccacatag cagaacttta 8280 aaagtgctca tcattggaaa
acgttcttcg gggcgaaaac tctcaaggat cttaccgctg 8340 ttgagatcca
gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact 8400
ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata
8460 agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta
ttgaagcatt 8520 tatcagggtt attgtctcat gagcggatac atatttgaat
gtatttagaa aaataaacaa 8580 ataggggttc cgcgcacatt tccccgaaaa
gtgccacctg acgtctaaga aaccattatt 8640 atcatgacat taacctataa
aaataggcgt atcacgaggc cctttcgtct tcaagaattc 8700 gagctcggta
cccatcagcc aaaaagcatg cctgccacac aacatcaatt tctggaaaac 8760
gctacactta attatttcta gtagaacagc tctttggttt gccaaaaaga atcacctata
8820 gtggcatcta agcacaaaaa ggagaaaaaa atcacaaaga aatgattgag
aggcataata 8880 aaaattatca aaaaattatg agttttacga tttcatcttt
ttccaagttg aaatcatagg 8940 gtggctttaa cacagtgaca aggaatgtgc
atgctgccat tatggtgctc tgcctaaaat 9000 ggttggagcc ttgtcatgct
acagagaaac tgtcatacag cagggggtgc caaatttcca 9060 tattttttta
tatcattgag caggtgcaca gaagaccaga aagcactttc tatcaggctg 9120
gccttcctct tcctttccag tatgaagcaa aaactgccaa tgaaactagc aattgttaaa
9180 ttcctttttc aaacagtatt tgtgctatca gaacatagtg cattcaaaag
tctagcctga 9240 gagaacaacc cagttttatt cattcctcct actacctctc
tcattcccac tgtttgtgtt 9300 ctccctccca ttttaattgt ctatctagtc
caaactaagc acacgatcca gtccacatta 9360 aacaacatgt tttcacttta
agtcaaatac aagacacctt taatatcagc ccttgttcat 9420 aatcgtgctt
ctagtgactt aatgtacatg tcacactgta ctgttgggtt ttgtgtctca 9480
tcatgaacaa tgttgtgaag gtattaagtg gagagtaagc agaattagat tcctctaatg
9540 atgcacaccc acactaagag cagaaataat attaaaaata gaaaaaaaag
ttttacatga 9600 gatttcaaat acccaggtat gagctgcagt ttcttcaagt
taaagcatcg aggttgtcag 9660 ttacactatt acaggaaaca tatgcagagt
ttttatttta gtatattagt tttcacatat 9720 gtggaattac tattaaacta
ttctttcttt tcaaatgctt accattgtaa atgagtttgt 9780 gactttgtgt
aggtgagtgc acatgactct ggatgcctaa gaggactgaa gaagttggag 9840
ttataggtag ttttattcta cttgactgtt cagtgctaaa aatacaactg aggtccttta
9900 aactgctgtt catgaacttc ttaattgata tatctcatga gatctctaaa
ctatttttat 9960 tatgacacgt ttcaccattt tcactgtaac gatttttatg
ttttatatta atgtaactat 10020 atgacacttc ccaaaatccc catattcaca
attgaactgt ttcaaagttt taccttgact 10080 tatgggaaat gaaaacccac
attttataat tttaaaatga aatgtttatt ttatatttct 10140 gcaaatttca
caaggaaaga ttagtcactg gtgtgtgaga gcagaggagc ataagagttc 10200
aggaatagaa tccattatga ttctggaggc aaggaagaac tgatgccaag gtttcagtat
10260 aagagcagta tccactggaa aggataaagt cactacatct gagcacagag
caggacatct 10320 acataatgag tggtcactaa tgggccactg ttacactgtt
atatgtataa ggctcaagaa 10380 tgagcactga ggctgtaagg tgtatgggtg
aggacatcag gatgtaaacc cagctcaggt 10440 agaggactca gaggacagca
cagtcagcat gaactaataa acatcagata agataaggca 10500 caagctcagc
tatatagggt aagggatctt tgtaaatctg attgtgcatc cagtctagtt 10560
caatgtgact taggaagccc agtcatatgc aaatctagag aagactttag agtagaaatc
10620 tgaggctcac ctcacatacc agcaagcgag tgaccagtta gtcttaaggc
accacttctt 10680 agacatcatg gcttgggtgt ggaccttgcc attcctgatg
gcagctgccc aaagtaagac 10740 atcagaaaaa agagttccaa ggggaattga
agcagttcca tgaatactca ccttcctgtg 10800 ttcttttcac aggtgtccag
gcagaggtgc agctggtgga gtcaggagcc gaagtgaaaa 10860 agcctggggc
ttcagtgaag gtgtcctgca aggcctctgg atacacattc actaattata 10920
ttatccactg ggtgaagcag gagcctggtc agggccttga atggattgga tattttaatc
10980 cttacaatca tggtactaag tacaatgaga agttcaaagg cagggccaca
ctaactgcag 11040 acaaatccat cagcacagcc tacatggagc tcagcagcct
gcgctctgag gacactgcgg 11100 tctactactg tgcaagatca ggaccctatg
cctggtttga cacctggggc caagggacca 11160 cggtcaccgt ctcctcaggt
aagaatggcc actctagggc ctttgttttc tgctgctgcc 11220 tgtgggattt
catgagcatt gcaaagttgt cctcgggaca tgttccgagg ggacctgggc 11280
ggactggcca ggaggggacg ggcactgggg tgccttgagg atctgggagc ctctgtggat
11340 tttccgatgc ctttggaaaa tgggactgag gttgggtgcg tctgagacag
taactcagcc 11400 tgggggcttg gtgaagatcg ccgcacagca gcgagtccgt
gaaatatctt atttagactt 11460 gtgaggtgcg ctgtgtgtca atttacatct
taaatccttt attggctgga aagagaattg 11520 ttggagtggg tgaatccagc
caggagggac gcggggggat cca 11563 <210> SEQ ID NO 38
<211> LENGTH: 11563 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic expression vector <220> FEATURE:
<223> OTHER INFORMATION: Nucleotide sequence of the
expression vector HCVHQN73DSp20 <400> SEQUENCE: 38 ctagagaggt
ctggtggagc ctgcaaaagt ccagctttca aaggaacaca gaagtatgtg 60
tatggaatat tagaagatgt tgcttttact cttaagttgg ttcctaggaa aaatagttaa
120 atactgtgac tttaaaatgt gagagggttt tcaagtactc atttttttaa
atgtccaaaa 180 tttttgtcaa tcaatttgag gtcttgtttg tgtagaactg
acattactta aagtttaacc 240 gaggaatggg agtgaggctc tctcataccc
tattcagaac tgacttttaa caataataaa 300 ttaagtttaa aatattttta
aatgaattga gcaatgttga gttggagtca agatggccga 360 tcagaaccag
aacacctgca gcagctggca ggaagcaggt catgtggcaa ggctatttgg 420
ggaagggaaa ataaaaccac taggtaaact tgtagctgtg gtttgaagaa gtggttttga
480 aacactctgt ccagccccac caaaccgaaa gtccaggctg agcaaaacac
cacctgggta 540 atttgcattt ctaaaataag ttgaggattc agccgaaact
ggagaggtcc tcttttaact 600 tattgagttc aaccttttaa ttttagcttg
agtagttcta gtttccccaa acttaagttt 660 atcgacttct aaaatgtatt
taagctttct ggggcaggcc aggcctgacc ttggctttgg 720 ggcagggagg
gggctaaggt gaggcaggtg gcgccagcca ggtgcacacc caatgcccat 780
gagcccagac actggacgct gaacctcgcg gacagttaag aacccagggg cctctgcgcc
840 ctgggcccag ctctgtccca caccgcggtc acatggcacc acctctcttg
cagcctccac 900 caagggccca tcggtcttcc ccctggcacc ctcctccaag
agcacctctg ggggcacagc 960 ggccctgggc tgcctggtca aggactactt
ccccgaaccg gtgacggtgt cgtggaactc 1020 aggcgccctg accagcggcg
tgcacacctt cccggctgtc ctacagtcct caggactcta 1080 ctccctcagc
agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg 1140
caacgtgaat cacaagccca gcaacaccaa ggtggacaag agagttggtg agaggccagc
1200 acagggaggg agggtgtctg ctggaagcca ggctcagcgc tcctgcctgg
acgcatcccg 1260 gctatgcagt cccagtccag ggcagcaagg caggccccgt
ctgcctcttc acccggaggc 1320 ctctgcccgc cccactcatg ctcagggaga
gggtcttctg gctttttccc caggctctgg 1380 gcaggcacag gctaggtgcc
cctaacccag gccctgcaca caaaggggca ggtgctgggc 1440 tcagacctgc
caagagccat atccgggagg accctgcccc tgacctaagc ccaccccaaa 1500
ggccaaactc tccactccct cagctcggac accttctctc ctcccagatt ccagtaactc
1560 ccaatcttct ctctgcagag cccaaatctt gtgacaaaac tcacacatgc
ccaccgtgcc 1620 caggtaagcc agcccaggcc tcgccctcca gctcaaggcg
ggacaggtgc cctagagtag 1680 cctgcatcca gggacaggcc ccagccgggt
gctgacacgt ccacctccat ctcttcctca 1740 gcacctgaac tcctgggggg
accgtcagtc ttcctcttcc ccccaaaacc caaggacacc 1800 ctcatgatct
cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 1860
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag
1920 ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac
cgtcctgcac 1980 caggactggc tgaatggcaa ggagtacaag tgcaaggtct
ccaacaaagc cctcccagcc 2040 cccatcgaga aaaccatctc caaagccaaa
ggtgggaccc gtggggtgcg agggccacat 2100 ggacagaggc cggctcggcc
caccctctgc cctgagagtg accgctgtac caacctctgt 2160 ccctacaggg
cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat 2220
gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc
2280 cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc
ctcccgtgct 2340 ggactccgac ggctccttct tcctctatag caagctcacc
gtggacaaga gcaggtggca 2400 gcaggggaac gtcttctcat gctccgtgat
gcatgaggct ctgcacaacc actacacgca 2460 gaagagcctc tccctgtccc
cgggtaaatg agtgcgacgg ccggcaagcc cccgctcccc 2520 gggctctcgc
ggtcgcacga ggatgcttgg cacgtacccc gtctacatac ttcccaggca 2580
cccagcatgg aaataaagca cccaccactg ccctgggccc ctgcgagact gtgatggttc
2640 tttccacggg tcaggccgag tctgaggcct gagtggcatg agggaggcag
agcgggtccc 2700 actgtcccca cactggccca ggctgtgcag gtgtgcctgg
gccgcctagg gtggggctca 2760 gccaggggct gccctcggca gggtggggga
tttgccagcg tggccctccc tccagcagca 2820 gctgccctgg gctgggccac
gagaagccct aggagcccct ggggacagac acacagcccc 2880 tgcctctgta
ggagactgtc ctgtcctgtg agcgccctgt cctccgaccc cgatgcccac 2940
tcgggggcat gcctagtcca tgcgcgtagg gacaggccct ccctcaccca tctaccccca
3000 cggcactaac ccctggcagc cctgcccagc ctcgcacccg catggggaca
caaccgactc 3060 cggggacatg cactctcggg ccctgtggag ggactggtgc
agatgcccac acacacactc 3120 agcccagacc cgttcaacaa accccgcact
gaggttggtc gagcgggagt gcggccagag 3180 cctgcctcgg ccgtcaggga
ggactcccgg gctcactcga aggaggtgcc accatttcag 3240 ctttggtagc
ttttcttctt cttttaaatt ttctaaagct cattaattgt ctttgatgtt 3300
tcttttgtga tgacaataaa atatcctttt taagtcttgt acttcgtgat gggagccgcc
3360 ttcctgtgtc cacgcgcctc ctgcccccgg tgggaagcac ggtcaggagg
aggctggtcc 3420 agctgcacct cgggggctcc ctgcactcgc cccccgcctc
ctgcagccac acgcattgcc 3480 cgagcgaccc tccctggccc ctgtcactac
atggacccct ggggcttctc ctcttttcta 3540 catggatgca gtttctcctc
ctgctgggca cggtgctgcc tgccctggtc actctgcggg 3600 ggacagggcc
tccagggaaa gctgggtcga ggctgggagc tggctcaggc tggccaggca 3660
gagccacagg gagggccttc cagaaccaac catggtccga agcgagaggt gggtgtcaga
3720 tccagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa
tgcagtgaaa 3780 aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta
tttgtaacca ttataagctg 3840 caataaacaa gttaacaaca acaattgcat
tcattttatg tttcaggttc agggggaggt 3900 gtgggaggtt ttttaaagca
agtaaaacct ctacaaatgt ggtatggctg attatgatct 3960 ctagtcaagg
cactatacat caaatattcc ttattaaccc ctttacaaat taaaaagcta 4020
aaggtacaca atttttgagc atagttatta atagcagaca ctctatgcct gtgtggagta
4080 agaaaaaaca gtatgttatg attataactg ttatgcctac ttataaaggt
tacagaatat 4140 ttttccataa ttttcttgta tagcagtgca gctttttcct
ttgtggtgta aatagcaaag 4200 caagcaagag ttctattact aaacacagca
tgactcaaaa aacttagcaa ttctgaagga 4260 aagtccttgg ggtcttctac
ctttctcttc ttttttggag gagtagaatg ttgagagtca 4320 gcagtagcct
catcatcact agatggcatt tcttctgagc aaaacaggtt ttcctcatta 4380
aaggcattcc accactgctc ccattcatca gttccatagg ttggaatcta aaatacacaa
4440 acaattagaa tcagtagttt aacacattat acacttaaaa attttatatt
taccttagag 4500 ctttaaatct ctgtaggtag tttgtccaat tatgtcacac
cacagaagta aggttccttc 4560 acaaagatcc ggaccaaagc ggccatcgtg
cctccccact cctgcagttc gggggcatgg 4620 atgcgcggat agccgctgct
ggtttcctgg atgccgacgg atttgcactg ccggtagaac 4680 tccgcgaggt
cgtccagcct caggcagcag ctgaaccaac tcgcgagggg atcgagcccg 4740
gggtgggcga agaactccag catgagatcc ccgcgctgga ggatcatcca gccggcgtcc
4800 cggaaaacga ttccgaagcc caacctttca tagaaggcgg cggtggaatc
gaaatctcgt 4860 gatggcaggt tgggcgtcgc ttggtcggtc atttcgaacc
ccagagtccc gctcagaaga 4920 actcgtcaag aaggcgatag aaggcgatgc
gctgcgaatc gggagcggcg ataccgtaaa 4980 gcacgaggaa gcggtcagcc
cattcgccgc caagctcttc agcaatatca cgggtagcca 5040 acgctatgtc
ctgatagcgg tccgccacac ccagccggcc acagtcgatg aatccagaaa 5100
agcggccatt ttccaccatg atattcggca agcaggcatc gccatgggtc acgacgagat
5160 cctcgccgtc gggcatgcgc gccttgagcc tggcgaacag ttcggctggc
gcgagcccct 5220 gatgctcttc gtccagatca tcctgatcga caagaccggc
ttccatccga gtacgtgctc 5280 gctcgatgcg atgtttcgct tggtggtcga
atgggcaggt agccggatca agcgtatgca 5340 gccgccgcat tgcatcagcc
atgatggata ctttctcggc aggagcaagg tgagatgaca 5400 ggagatcctg
ccccggcact tcgcccaata gcagccagtc ccttcccgct tcagtgacaa 5460
cgtcgagcac agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct
5520 cgtcctgcag ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga
accgggcgcc 5580 cctgcgctga cagccggaac acggcggcat cagagcagcc
gattgtctgt tgtgcccagt 5640 catagccgaa tagcctctcc acccaagcgg
ccggagaacc tgcgtgcaat ccatcttgtt 5700 caatcatgcg aaacgatcct
catcctgtct cttgatcaga tcttgatccc ctgcgccatc 5760 agatccttgg
cggcaagaaa gccatccagt ttactttgca gggcttccca accttaccag 5820
agggcgcccc agctggcaat tccggttcgc ttgctgtcca taaaaccgcc cagtctagct
5880 atcgccatgt aagcccactg caagctacct gctttctctt tgcgcttgcg
ttttcccttg 5940 tccagatagc ccagtagctg acattcatcc ggggtcagca
ccgtttctgc ggactggctt 6000 tctacgtgtt ccgcttcctt tagcagccct
tgcgccctga gtgcttgcgg cagcgtgaag 6060 ctttttgcaa aagcctaggc
ctccaaaaaa gcctcctcac tacttctgga atagctcaga 6120 ggccgaggcg
gcctcggcct ctgcataaat aaaaaaaatt agtcagccat ggggcggaga 6180
atgggcggaa ctgggcggag ttaggggcgg gatgggcgga gttaggggcg ggactatggt
6240 tgctgactaa ttgagatgca tgctttgcat acttctgcct gctggggagc
ctggggactt 6300 tccacacctg gttgctgact aattgagatg catgctttgc
atacttctgc ctgctgggga 6360 gcctggggac tttccacacc ctaactgaca
cacattccac agctgcctcg cgcgtttcgg 6420 tgatgacggt gaaaacctct
gacacatgca gctcccggag acggtcacag cttgtctgta 6480 agcggatgcc
gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg 6540
gggcgcagcc atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg
6600 gcatcagagc agattgtact gagagtgcac catatgcggt gtgaaatacc
gcacagatgc 6660 gtaaggagaa aataccgcat caggcgctct tccgcttcct
cgctcactga ctcgctgcgc 6720 tcggtcgttc ggctgcggcg agcggtatca
gctcactcaa aggcggtaat acggttatcc 6780 acagaatcag gggataacgc
aggaaagaac atgtgagcaa aaggccagca aaaggccagg 6840 aaccgtaaaa
aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat 6900
cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag
6960 gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc
gcttaccgga 7020 tacctgtccg cctttctccc ttcgggaagc gtggcgcttt
ctcatagctc acgctgtagg 7080 tatctcagtt cggtgtaggt cgttcgctcc
aagctgggct gtgtgcacga accccccgtt 7140 cagcccgacc gctgcgcctt
atccggtaac tatcgtcttg agtccaaccc ggtaagacac 7200 gacttatcgc
cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc 7260
ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt
7320 ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag
ctcttgatcc 7380 ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt
gcaagcagca gattacgcgc 7440 agaaaaaaag gatctcaaga agatcctttg
atcttttcta cggggtctga cgctcagtgg 7500 aacgaaaact cacgttaagg
gattttggtc atgagattat caaaaaggat cttcacctag 7560 atccttttaa
attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg 7620
tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt
7680 tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga
gggcttacca 7740 tctggcccca gtgctgcaat gataccgcga gacccacgct
caccggctcc agatttatca 7800 gcaataaacc agccagccgg aagggccgag
cgcagaagtg gtcctgcaac tttatccgcc 7860 tccatccagt ctattaattg
ttgccgggaa gctagagtaa gtagttcgcc agttaatagt 7920 ttgcgcaacg
ttgttgccat tgctgcaggc atcgtggtgt cacgctcgtc gtttggtatg 7980
gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc
8040 aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt
ggccgcagtg 8100 ttatcactca tggttatggc agcactgcat aattctctta
ctgtcatgcc atccgtaaga 8160 tgcttttctg tgactggtga gtactcaacc
aagtcattct gagaatagtg tatgcggcga 8220 ccgagttgct cttgcccggc
gtcaacacgg gataataccg cgccacatag cagaacttta 8280 aaagtgctca
tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg 8340
ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact
8400 ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa
aaagggaata 8460 agggcgacac ggaaatgttg aatactcata ctcttccttt
ttcaatatta ttgaagcatt 8520 tatcagggtt attgtctcat gagcggatac
atatttgaat gtatttagaa aaataaacaa 8580 ataggggttc cgcgcacatt
tccccgaaaa gtgccacctg acgtctaaga aaccattatt 8640 atcatgacat
taacctataa aaataggcgt atcacgaggc cctttcgtct tcaagaattc 8700
gagctcggta cccatcagcc aaaaagcatg cctgccacac aacatcaatt tctggaaaac
8760 gctacactta attatttcta gtagaacagc tctttggttt gccaaaaaga
atcacctata 8820 gtggcatcta agcacaaaaa ggagaaaaaa atcacaaaga
aatgattgag aggcataata 8880 aaaattatca aaaaattatg agttttacga
tttcatcttt ttccaagttg aaatcatagg 8940 gtggctttaa cacagtgaca
aggaatgtgc atgctgccat tatggtgctc tgcctaaaat 9000 ggttggagcc
ttgtcatgct acagagaaac tgtcatacag cagggggtgc caaatttcca 9060
tattttttta tatcattgag caggtgcaca gaagaccaga aagcactttc tatcaggctg
9120 gccttcctct tcctttccag tatgaagcaa aaactgccaa tgaaactagc
aattgttaaa 9180 ttcctttttc aaacagtatt tgtgctatca gaacatagtg
cattcaaaag tctagcctga 9240 gagaacaacc cagttttatt cattcctcct
actacctctc tcattcccac tgtttgtgtt 9300 ctccctccca ttttaattgt
ctatctagtc caaactaagc acacgatcca gtccacatta 9360 aacaacatgt
tttcacttta agtcaaatac aagacacctt taatatcagc ccttgttcat 9420
aatcgtgctt ctagtgactt aatgtacatg tcacactgta ctgttgggtt ttgtgtctca
9480 tcatgaacaa tgttgtgaag gtattaagtg gagagtaagc agaattagat
tcctctaatg 9540 atgcacaccc acactaagag cagaaataat attaaaaata
gaaaaaaaag ttttacatga 9600 gatttcaaat acccaggtat gagctgcagt
ttcttcaagt taaagcatcg aggttgtcag 9660 ttacactatt acaggaaaca
tatgcagagt ttttatttta gtatattagt tttcacatat 9720 gtggaattac
tattaaacta ttctttcttt tcaaatgctt accattgtaa atgagtttgt 9780
gactttgtgt aggtgagtgc acatgactct ggatgcctaa gaggactgaa gaagttggag
9840 ttataggtag ttttattcta cttgactgtt cagtgctaaa aatacaactg
aggtccttta 9900 aactgctgtt catgaacttc ttaattgata tatctcatga
gatctctaaa ctatttttat 9960 tatgacacgt ttcaccattt tcactgtaac
gatttttatg ttttatatta atgtaactat 10020 atgacacttc ccaaaatccc
catattcaca attgaactgt ttcaaagttt taccttgact 10080 tatgggaaat
gaaaacccac attttataat tttaaaatga aatgtttatt ttatatttct 10140
gcaaatttca caaggaaaga ttagtcactg gtgtgtgaga gcagaggagc ataagagttc
10200 aggaatagaa tccattatga ttctggaggc aaggaagaac tgatgccaag
gtttcagtat 10260 aagagcagta tccactggaa aggataaagt cactacatct
gagcacagag caggacatct 10320 acataatgag tggtcactaa tgggccactg
ttacactgtt atatgtataa ggctcaagaa 10380 tgagcactga ggctgtaagg
tgtatgggtg aggacatcag gatgtaaacc cagctcaggt 10440 agaggactca
gaggacagca cagtcagcat gaactaataa acatcagata agataaggca 10500
caagctcagc tatatagggt aagggatctt tgtaaatctg attgtgcatc cagtctagtt
10560 caatgtgact taggaagccc agtcatatgc aaatctagag aagactttag
agtagaaatc 10620 tgaggctcac ctcacatacc agcaagcgag tgaccagtta
gtcttaaggc accacttctt 10680 agacatcatg gcttgggtgt ggaccttgcc
attcctgatg gcagctgccc aaagtaagac 10740 atcagaaaaa agagttccaa
ggggaattga agcagttcca tgaatactca ccttcctgtg 10800 ttcttttcac
aggtgtccag gcacaggtgc agctggtgga gtcaggagcc gaagtgaaaa 10860
agcctggggc ttcagtgaag gtgtcctgca aggcctctgg atacacattc actaattata
10920 ttatccactg ggtgaagcag gagcctggtc agggccttga atggattgga
tattttaatc 10980 cttacaatca tggtactaag tacaatgaga agttcaaagg
cagggccaca ctaactgcag 11040 acaaatccat cagcacagcc tacatggagc
tcagcagcct gcgctctgag gacactgcgg 11100 tctactactg tgcaagatca
ggaccctatg cctggtttga cacctggggc caagggacca 11160 cggtcaccgt
ctcctcaggt aagaatggcc actctagggc ctttgttttc tgctgctgcc 11220
tgtgggattt catgagcatt gcaaagttgt cctcgggaca tgttccgagg ggacctgggc
11280 ggactggcca ggaggggacg ggcactgggg tgccttgagg atctgggagc
ctctgtggat 11340 tttccgatgc ctttggaaaa tgggactgag gttgggtgcg
tctgagacag taactcagcc 11400 tgggggcttg gtgaagatcg ccgcacagca
gcgagtccgt gaaatatctt atttagactt 11460 gtgaggtgcg ctgtgtgtca
atttacatct taaatccttt attggctgga aagagaattg 11520 ttggagtggg
tgaatccagc caggagggac gcggggggat cca 11563 <210> SEQ ID NO 39
<211> LENGTH: 8096 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic expression vector <220> FEATURE:
<223> OTHER INFORMATION: Nucleotide sequence of expression
vector LCVL2Sp20 <400> SEQUENCE: 39 ctagagtcct agagaggtct
ggtggagcct gcaaaagtcc agctttcaaa ggaacacaga 60 agtatgtgta
tggaatatta gaagatgttg cttttactct taagttggtt cctaggaaaa 120
atagttaaat actgtgactt taaaatgtga gagggttttc aagtactcat ttttttaaat
180 gtccaaaatt tttgtcaatc aatttgaggt cttgtttgtg tagaactgac
attacttaaa 240 gtttaaccga ggaatgggag tgaggctctc tcatacccta
ttcagaactg acttttaaca 300 ataataaatt aagtttaaaa tatttttaaa
tgaattgagc aatgttgagt tggagtcaag 360 atggccgatc agaaccagaa
cacctgcagc agctggcagg aagcaggtca tgtggcaagg 420 ctatttgggg
aagggaaaat aaaaccacta ggtaaacttg tagctgtggt ttgaagaagt 480
ggttttgaaa cactctgtcc agccccacca aaccgaaagt ccaggctgag caaaacacca
540 cctgggtaat ttgcatttct aaaataagtt gaggattcag ccgaaactgg
agaggtcctc 600 ttttaactta ttgagttcaa ccttttaatt ttagcttgag
tagttctagt ttccccaaac 660 ttaagtttat cgacttctaa aatgtattta
gaactcattt tcaaaattag gttatgtaag 720 aaattgaagg actttagtgt
ctttaatttc taatatattt agaaaacttc ttaaaattac 780 tctattattc
ttccctctga ttattggtct ccattcaatt cttttccaat acccgaagca 840
tttacagtga ctttgttcat gatctttttt agttgtttgt tttgccttac tattaagact
900 ttgacattct ggtcaaaacg gcttcacaaa tctttttcaa gaccactttc
tgagtattca 960 ttttaggaga aatacttttt ttttaaatga atgcaattat
ctaggacctg caggcatgct 1020 gttttctgtc tgtccctaac atgccctgtg
attatccgca aacaacacac ccaagggcag 1080 aactttgtta cttaaacacc
atcctgtttg cttctttcct caggaactgt ggctgcacca 1140 tctgtcttca
tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg 1200
tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc
1260 ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga
cagcacctac 1320 agcctcagca gcaccctgac gctgagcaaa gcagactacg
agaaacacaa agtctacgcc 1380 tgcgaagtca cccatcaggg cctgagctcg
cccgtcacaa agagcttcaa caggggagag 1440 tgttagaggg agaagtgccc
ccacctgctc ctcagttcca gcctgacccc ctcccatcct 1500 ttggcctctg
accctttttc cacaggggac ctacccctat tgcggtcctc cagctcatct 1560
ttcacctcac ccccctcctc ctccttggct ttaattatgc taatgttgga ggagaatgaa
1620 taaataaagt gaatctttgc acctgtggtt tctctctttc ctcatttaat
aattattatc 1680 tgttgtttta ccaactactc aatttctctt ataagggact
aaatatgtag tcatcctaag 1740 gcgggatatc gagatctgaa gctgatccag
acatgataag atacattgat gagtttggac 1800 aaaccacaac tagaatgcag
tgaaaaaaat gctttatttg tgaaatttgt gatgctattg 1860 ctttatttgt
aaccattata agctgcaata aacaagttaa caacaacaat tgcattcatt 1920
ttatgtttca ggttcagggg gaggtgtggg aggtttttta aagcaagtaa aacctctaca
1980 aatgtggtat ggctgattat gatctctagt caaggcacta tacatcaaat
attccttatt 2040 aaccccttta caaattaaaa agctaaaggt acacaatttt
tgagcatagt tattaatagc 2100 agacactcta tgcctgtgtg gagtaagaaa
aaacagtatg ttatgattat aactgttatg 2160 cctacttata aaggttacag
aatatttttc cataattttc ttgtatagca gtgcagcttt 2220 ttcctttgtg
gtgtaaatag caaagcaagc aagagttcta ttactaaaca cagcatgact 2280
caaaaaactt agcaattctg aaggaaagtc cttggggtct tctacctttc tcttcttttt
2340 tggaggagta gaatgttgag agtcagcagt agcctcatca tcactagatg
gcatttcttc 2400 tgagcaaaac aggttttcct cattaaaggc attccaccac
tgctcccatt catcagttcc 2460 ataggttgga atctaaaata cacaaacaat
tagaatcagt agtttaacac attatacact 2520 taaaaatttt atatttacct
tagagcttta aatctctgta ggtagtttgt ccaattatgt 2580 cacaccacag
aagtaaggtt ccttcacaaa gatccggacc aaagcggcca tcgtgcctcc 2640
ccactcctgc agttcggggg catggatgcg cggatagccg ctgctggttt cctggatgcc
2700 gacggatttg cactgccggt agaactccgc gaggtcgtcc agcctcaggc
agcagctgaa 2760 ccaactcgcg aggggatcga gcatccccca tggtcttata
aaaatgcata gctttaggag 2820 gggagcagag aacttgaaag catcttcctg
ttagtctttc ttctcgtaga cttcaaactt 2880 atacttgatg cctttttcct
cctggacctc agagaggacg cctgggtatt ctgggagaag 2940 tttatatttc
cccaaatcaa tttctgggaa aaacgtgtca ctttcaaatt cctgcatgat 3000
ccttgtcaca aagagtctga ggtggcctgg ttgattcatg gcttcctggt aaacagaact
3060 gcctccgact atccaaacca tgtctacttt acttgccaat tccggttgtt
caataagtct 3120 taaggcatca tccaaacttt tggcaagaaa atgagctcct
cgtggtggtt ctttgagttc 3180 tctactgaga actatattaa ttctgtcctt
taaaggtcga ttcttctcag gaatggagaa 3240 ccaggttttc ctacccataa
tcaccagatt ctgtttacct tccactgaag aggttgtggt 3300 cattctttgg
aagtacttga actcgttcct gagcggaggc cagggtcggt ctccgttctt 3360
gccaatcccc atattttggg acacggcgac gatgcagttc aatggtcgaa ccatgatggc
3420 agcggggata aaatcctacc agccttcacg ctaggattgc cgtcaagttt
gggggtaccg 3480 agctcgaatt agctttttgc aaaagcctag gcctccaaaa
aagcctcctc actacttctg 3540 gaatagctca gagggccgag gcggcctcgg
cctctgcata aataaaaaaa attagtcagc 3600 catggggcgg agaatgggcg
gaactgggcg gagttagggg cgggatgggc ggagttaggg 3660 gcgggactat
ggttgctgac taattgagat gcatgctttg catacttctg cctgctgggg 3720
agcctgggga ctttccacac ctggttgctg actaattgag atgcatgctt tgcatacttc
3780 tgcctgctgg ggagcctggg gactttccac accctaactg acacacattc
cacagctgcc 3840 tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat
gcagctcccg gagacggtca 3900 cagcttgtct gtaagcggat gccgggagca
gacaagcccg tcagggcgcg tcagcgggtg 3960 ttggcgggtg tcggggcgca
gccatgaccc agtcacgtag cgatagcgga gtgtatactg 4020 gcttaactat
gcggcatcag agcagattgt actgagagtg caccatatgc ggccgcatat 4080
gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc gctcttccgc
4140 ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg
tatcagctca 4200 ctcaaaggcg gtaatacggt tatccacaga atcaggggat
aacgcaggaa agaacatgtg 4260 agcaaaaggc cagcaaaagg ccaggaaccg
taaaaaggcc gcgttgctgg cgtttttcca 4320 taggctccgc ccccctgacg
agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa 4380 cccgacagga
ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc 4440
tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc
4500 gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc
gctccaagct 4560 gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc
gccttatccg gtaactatcg 4620 tcttgagtcc aacccggtaa gacacgactt
atcgccactg gcagcagcca ctggtaacag 4680 gattagcaga gcgaggtatg
taggcggtgc tacagagttc ttgaagtggt ggcctaacta 4740 cggctacact
agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg 4800
aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt
4860 tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc
ctttgatctt 4920 ttctacgggg tctgacgctc agtggaacga aaactcacgt
taagggattt tggtcatgag 4980 attatcaaaa aggatcttca cctagatcct
tttaaattaa aaatgaagtt ttaaatcaat 5040 ctaaagtata tatgagtaaa
cttggtctga cagttaccaa tgcttaatca gtgaggcacc 5100 tatctcagcg
atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat 5160
aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc
5220 acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg
ccgagcgcag 5280 aagtggtcct gcaactttat ccgcctccat ccagtctatt
aattgttgcc gggaagctag 5340 agtaagtagt tcgccagtta atagtttgcg
caacgttgtt gccattgctg caggcatcgt 5400 ggtgtcacgc tcgtcgtttg
gtatggcttc attcagctcc ggttcccaac gatcaaggcg 5460 agttacatga
tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt 5520
tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc
5580 tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact
caaccaagtc 5640 attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc
ccggcgtcaa cacgggataa 5700 taccgcgcca catagcagaa ctttaaaagt
gctcatcatt ggaaaacgtt cttcggggcg 5760 aaaactctca aggatcttac
cgctgttgag atccagttcg atgtaaccca ctcgtgcacc 5820 caactgatct
tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag 5880
gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt
5940 cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg
gatacatatt 6000 tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc
acatttcccc gaaaagtgcc 6060 acctgacgtc taagaaacca ttattatcat
gacattaacc tataaaaata ggcgtatcac 6120 gaggcccttt cgtcttcaag
aattcagctg ctcgaggaag agctcaaacc catgctactc 6180 tctggcttga
tggaagcaac gctttcatag ctgagctgtc ataaataata aagagatttt 6240
tttattaata ttgaaaagat gggttattta tgtaagactc tgtcttcatt ttaaaaacca
6300 caccttccag tagtattctg ttactgttct ggcaatcact gtgatcaaga
agctacacgg 6360 tgagttgtgc ttctcagtcc taagggatac atctacaaga
ggctcccata ctcgaagctc 6420 aggaaacatt gtagaaaagg aggcaaaaga
ctgacagagc cagaggacca agaaatttgt 6480 tgtgaggttg tgtctcctac
taacaatata agcaatatct ataaattgtt gatatcatgg 6540 ctactaaaat
gtgagttgaa cgaggaggac acaaatgaac atgacaatca gaatgaggcc 6600
tctcacctgc aaaaaacact atagagaagc agataaagct gtcagcagaa gaggcgcacc
6660 tccttataga agaagcctac caggtttgat atatcagcct tgaaaaccta
catagtattt 6720 acattatatc gagtctatga gacatattta gtaatgcata
tgtatgtgtg tgtgtgcatg 6780 tatgtgtgta aatacatatg ttcatagaaa
aatgtgtaaa aagagatcat gaatttaaga 6840 gagaactggg acaatttttt
tcagggagtt gtaatcagga aagttaaggg aaaaatgttg 6900 taattaaaat
tcaggctcag aaacaaacaa aggaaaagaa aaaaaaacaa caacaacaac 6960
aaaaaaacaa aacaaaggag aagctgtatg gccacaatag catctacagc taactgtgaa
7020 aggataatgg aacaagttat gtactgccta gagcagtatg atgcctaaat
catctcgaca 7080 tggaggaaaa tagaacaaag acactctaca tagactatga
tagaaatcaa aataaggtgt 7140 aagacataga acattagttt tgtttgttgt
tcaaagagac tcacattccc acaaaaaaat 7200 ctgtgggatt ttacaggtct
gcaataagct gctgacctga tgatttctgc agctgtgcct 7260 accctttgct
gatttgcatg tacccaaagc atagcttact gacatgagga tttcttcata 7320
gtcaggtcac accctttgct ggagtcagaa tcacactgat cacacacagt catgagtgtg
7380 ctcactcagg tcctggcgtt gctgctgctg tggcttacag gtaatgaaga
cagcactaga 7440 attttattga gcttcctgta cactgtgctg cttgtctctg
tgaaaattct cttgtgaatt 7500 aatcatgtgg ggatctgttt tcaatttttc
aattgtaggt acgcgttgtg acattctgct 7560 gacccagtct ccagccaccc
tgtctctgag tccaggagaa agagccactt tctcctgcag 7620 ggccagtcag
aacattggca caagcataca gtggtatcaa caaaaaacaa atggtgctcc 7680
aaggcttctc ataaggtctt cttctgagtc tatctctggg atcccttcca ggtttagtgg
7740 cagtggatca gggacagatt ttactcttac catcagcagt ctggagcctg
aagattttgc 7800 agtgtattac tgtcaacaaa gtaatacctg gccattcacg
ttcggccagg ggaccaagct 7860 tgaaatcaaa cgtaagtaga atccaaagtc
tctttcttcc gttgtctatg tctgtggctt 7920 ctatgtctaa aaatgatgta
taaaatctta ctctgaaacc agattctggc actctccaag 7980 gcaaagatac
agagtaactc cgtaagcaaa gctgggaata ggctagacat gttctctgga 8040
gaatgaatgc cagtgtaata attaacacaa gtgatagttt cagaaatgct ctagtt 8096
<210> SEQ ID NO 40 <211> LENGTH: 11563 <212>
TYPE: DNA <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: synthetic expression vector
<220> FEATURE: <223> OTHER INFORMATION: Nucleotide
sequence of expression vector HCVHESp20 <400> SEQUENCE: 40
ctagagaggt ctggtggagc ctgcaaaagt ccagctttca aaggaacaca gaagtatgtg
60 tatggaatat tagaagatgt tgcttttact cttaagttgg ttcctaggaa
aaatagttaa 120 atactgtgac tttaaaatgt gagagggttt tcaagtactc
atttttttaa atgtccaaaa 180 tttttgtcaa tcaatttgag gtcttgtttg
tgtagaactg acattactta aagtttaacc 240 gaggaatggg agtgaggctc
tctcataccc tattcagaac tgacttttaa caataataaa 300 ttaagtttaa
aatattttta aatgaattga gcaatgttga gttggagtca agatggccga 360
tcagaaccag aacacctgca gcagctggca ggaagcaggt catgtggcaa ggctatttgg
420 ggaagggaaa ataaaaccac taggtaaact tgtagctgtg gtttgaagaa
gtggttttga 480 aacactctgt ccagccccac caaaccgaaa gtccaggctg
agcaaaacac cacctgggta 540 atttgcattt ctaaaataag ttgaggattc
agccgaaact ggagaggtcc tcttttaact 600 tattgagttc aaccttttaa
ttttagcttg agtagttcta gtttccccaa acttaagttt 660 atcgacttct
aaaatgtatt taagctttct ggggcaggcc aggcctgacc ttggctttgg 720
ggcagggagg gggctaaggt gaggcaggtg gcgccagcca ggtgcacacc caatgcccat
780 gagcccagac actggacgct gaacctcgcg gacagttaag aacccagggg
cctctgcgcc 840 ctgggcccag ctctgtccca caccgcggtc acatggcacc
acctctcttg cagcctccac 900 caagggccca tcggtcttcc ccctggcacc
ctcctccaag agcacctctg ggggcacagc 960 ggccctgggc tgcctggtca
aggactactt ccccgaaccg gtgacggtgt cgtggaactc 1020 aggcgccctg
accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta 1080
ctccctcagc agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg
1140 caacgtgaat cacaagccca gcaacaccaa ggtggacaag agagttggtg
agaggccagc 1200 acagggaggg agggtgtctg ctggaagcca ggctcagcgc
tcctgcctgg acgcatcccg 1260 gctatgcagt cccagtccag ggcagcaagg
caggccccgt ctgcctcttc acccggaggc 1320 ctctgcccgc cccactcatg
ctcagggaga gggtcttctg gctttttccc caggctctgg 1380 gcaggcacag
gctaggtgcc cctaacccag gccctgcaca caaaggggca ggtgctgggc 1440
tcagacctgc caagagccat atccgggagg accctgcccc tgacctaagc ccaccccaaa
1500 ggccaaactc tccactccct cagctcggac accttctctc ctcccagatt
ccagtaactc 1560 ccaatcttct ctctgcagag cccaaatctt gtgacaaaac
tcacacatgc ccaccgtgcc 1620 caggtaagcc agcccaggcc tcgccctcca
gctcaaggcg ggacaggtgc cctagagtag 1680 cctgcatcca gggacaggcc
ccagccgggt gctgacacgt ccacctccat ctcttcctca 1740 gcacctgaac
tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc 1800
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac
1860 cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc
caagacaaag 1920 ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca
gcgtcctcac cgtcctgcac 1980 caggactggc tgaatggcaa ggagtacaag
tgcaaggtct ccaacaaagc cctcccagcc 2040 cccatcgaga aaaccatctc
caaagccaaa ggtgggaccc gtggggtgcg agggccacat 2100 ggacagaggc
cggctcggcc caccctctgc cctgagagtg accgctgtac caacctctgt 2160
ccctacaggg cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat
2220 gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctatccca
gcgacatcgc 2280 cgtggagtgg gagagcaatg ggcagccgga gaacaactac
aagaccacgc ctcccgtgct 2340 ggactccgac ggctccttct tcctctatag
caagctcacc gtggacaaga gcaggtggca 2400 gcaggggaac gtcttctcat
gctccgtgat gcatgaggct ctgcacaacc actacacgca 2460 gaagagcctc
tccctgtccc cgggtaaatg agtgcgacgg ccggcaagcc cccgctcccc 2520
gggctctcgc ggtcgcacga ggatgcttgg cacgtacccc gtctacatac ttcccaggca
2580 cccagcatgg aaataaagca cccaccactg ccctgggccc ctgcgagact
gtgatggttc 2640 tttccacggg tcaggccgag tctgaggcct gagtggcatg
agggaggcag agcgggtccc 2700 actgtcccca cactggccca ggctgtgcag
gtgtgcctgg gccgcctagg gtggggctca 2760 gccaggggct gccctcggca
gggtggggga tttgccagcg tggccctccc tccagcagca 2820 gctgccctgg
gctgggccac gagaagccct aggagcccct ggggacagac acacagcccc 2880
tgcctctgta ggagactgtc ctgtcctgtg agcgccctgt cctccgaccc cgatgcccac
2940 tcgggggcat gcctagtcca tgcgcgtagg gacaggccct ccctcaccca
tctaccccca 3000 cggcactaac ccctggcagc cctgcccagc ctcgcacccg
catggggaca caaccgactc 3060 cggggacatg cactctcggg ccctgtggag
ggactggtgc agatgcccac acacacactc 3120 agcccagacc cgttcaacaa
accccgcact gaggttggtc gagcgggagt gcggccagag 3180 cctgcctcgg
ccgtcaggga ggactcccgg gctcactcga aggaggtgcc accatttcag 3240
ctttggtagc ttttcttctt cttttaaatt ttctaaagct cattaattgt ctttgatgtt
3300 tcttttgtga tgacaataaa atatcctttt taagtcttgt acttcgtgat
gggagccgcc 3360 ttcctgtgtc cacgcgcctc ctgcccccgg tgggaagcac
ggtcaggagg aggctggtcc 3420 agctgcacct cgggggctcc ctgcactcgc
cccccgcctc ctgcagccac acgcattgcc 3480 cgagcgaccc tccctggccc
ctgtcactac atggacccct ggggcttctc ctcttttcta 3540 catggatgca
gtttctcctc ctgctgggca cggtgctgcc tgccctggtc actctgcggg 3600
ggacagggcc tccagggaaa gctgggtcga ggctgggagc tggctcaggc tggccaggca
3660 gagccacagg gagggccttc cagaaccaac catggtccga agcgagaggt
gggtgtcaga 3720 tccagacatg ataagataca ttgatgagtt tggacaaacc
acaactagaa tgcagtgaaa 3780 aaaatgcttt atttgtgaaa tttgtgatgc
tattgcttta tttgtaacca ttataagctg 3840 caataaacaa gttaacaaca
acaattgcat tcattttatg tttcaggttc agggggaggt 3900 gtgggaggtt
ttttaaagca agtaaaacct ctacaaatgt ggtatggctg attatgatct 3960
ctagtcaagg cactatacat caaatattcc ttattaaccc ctttacaaat taaaaagcta
4020 aaggtacaca atttttgagc atagttatta atagcagaca ctctatgcct
gtgtggagta 4080 agaaaaaaca gtatgttatg attataactg ttatgcctac
ttataaaggt tacagaatat 4140 ttttccataa ttttcttgta tagcagtgca
gctttttcct ttgtggtgta aatagcaaag 4200 caagcaagag ttctattact
aaacacagca tgactcaaaa aacttagcaa ttctgaagga 4260 aagtccttgg
ggtcttctac ctttctcttc ttttttggag gagtagaatg ttgagagtca 4320
gcagtagcct catcatcact agatggcatt tcttctgagc aaaacaggtt ttcctcatta
4380 aaggcattcc accactgctc ccattcatca gttccatagg ttggaatcta
aaatacacaa 4440 acaattagaa tcagtagttt aacacattat acacttaaaa
attttatatt taccttagag 4500 ctttaaatct ctgtaggtag tttgtccaat
tatgtcacac cacagaagta aggttccttc 4560 acaaagatcc ggaccaaagc
ggccatcgtg cctccccact cctgcagttc gggggcatgg 4620 atgcgcggat
agccgctgct ggtttcctgg atgccgacgg atttgcactg ccggtagaac 4680
tccgcgaggt cgtccagcct caggcagcag ctgaaccaac tcgcgagggg atcgagcccg
4740 gggtgggcga agaactccag catgagatcc ccgcgctgga ggatcatcca
gccggcgtcc 4800 cggaaaacga ttccgaagcc caacctttca tagaaggcgg
cggtggaatc gaaatctcgt 4860 gatggcaggt tgggcgtcgc ttggtcggtc
atttcgaacc ccagagtccc gctcagaaga 4920 actcgtcaag aaggcgatag
aaggcgatgc gctgcgaatc gggagcggcg ataccgtaaa 4980 gcacgaggaa
gcggtcagcc cattcgccgc caagctcttc agcaatatca cgggtagcca 5040
acgctatgtc ctgatagcgg tccgccacac ccagccggcc acagtcgatg aatccagaaa
5100 agcggccatt ttccaccatg atattcggca agcaggcatc gccatgggtc
acgacgagat 5160 cctcgccgtc gggcatgcgc gccttgagcc tggcgaacag
ttcggctggc gcgagcccct 5220 gatgctcttc gtccagatca tcctgatcga
caagaccggc ttccatccga gtacgtgctc 5280 gctcgatgcg atgtttcgct
tggtggtcga atgggcaggt agccggatca agcgtatgca 5340 gccgccgcat
tgcatcagcc atgatggata ctttctcggc aggagcaagg tgagatgaca 5400
ggagatcctg ccccggcact tcgcccaata gcagccagtc ccttcccgct tcagtgacaa
5460 cgtcgagcac agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc
cgcgctgcct 5520 cgtcctgcag ttcattcagg gcaccggaca ggtcggtctt
gacaaaaaga accgggcgcc 5580 cctgcgctga cagccggaac acggcggcat
cagagcagcc gattgtctgt tgtgcccagt 5640 catagccgaa tagcctctcc
acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt 5700 caatcatgcg
aaacgatcct catcctgtct cttgatcaga tcttgatccc ctgcgccatc 5760
agatccttgg cggcaagaaa gccatccagt ttactttgca gggcttccca accttaccag
5820 agggcgcccc agctggcaat tccggttcgc ttgctgtcca taaaaccgcc
cagtctagct 5880 atcgccatgt aagcccactg caagctacct gctttctctt
tgcgcttgcg ttttcccttg 5940 tccagatagc ccagtagctg acattcatcc
ggggtcagca ccgtttctgc ggactggctt 6000 tctacgtgtt ccgcttcctt
tagcagccct tgcgccctga gtgcttgcgg cagcgtgaag 6060 ctttttgcaa
aagcctaggc ctccaaaaaa gcctcctcac tacttctgga atagctcaga 6120
ggccgaggcg gcctcggcct ctgcataaat aaaaaaaatt agtcagccat ggggcggaga
6180 atgggcggaa ctgggcggag ttaggggcgg gatgggcgga gttaggggcg
ggactatggt 6240 tgctgactaa ttgagatgca tgctttgcat acttctgcct
gctggggagc ctggggactt 6300 tccacacctg gttgctgact aattgagatg
catgctttgc atacttctgc ctgctgggga 6360 gcctggggac tttccacacc
ctaactgaca cacattccac agctgcctcg cgcgtttcgg 6420 tgatgacggt
gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta 6480
agcggatgcc gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg
6540 gggcgcagcc atgacccagt cacgtagcga tagcggagtg tatactggct
taactatgcg 6600 gcatcagagc agattgtact gagagtgcac catatgcggt
gtgaaatacc gcacagatgc 6660 gtaaggagaa aataccgcat caggcgctct
tccgcttcct cgctcactga ctcgctgcgc 6720 tcggtcgttc ggctgcggcg
agcggtatca gctcactcaa aggcggtaat acggttatcc 6780 acagaatcag
gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg 6840
aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat
6900 cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata
aagataccag 6960 gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc
cgaccctgcc gcttaccgga 7020 tacctgtccg cctttctccc ttcgggaagc
gtggcgcttt ctcatagctc acgctgtagg 7080 tatctcagtt cggtgtaggt
cgttcgctcc aagctgggct gtgtgcacga accccccgtt 7140 cagcccgacc
gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac 7200
gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc
7260 ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag
gacagtattt 7320 ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa
gagttggtag ctcttgatcc 7380 ggcaaacaaa ccaccgctgg tagcggtggt
ttttttgttt gcaagcagca gattacgcgc 7440 agaaaaaaag gatctcaaga
agatcctttg atcttttcta cggggtctga cgctcagtgg 7500 aacgaaaact
cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag 7560
atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg
7620 tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg
tctatttcgt 7680 tcatccatag ttgcctgact ccccgtcgtg tagataacta
cgatacggga gggcttacca 7740 tctggcccca gtgctgcaat gataccgcga
gacccacgct caccggctcc agatttatca 7800 gcaataaacc agccagccgg
aagggccgag cgcagaagtg gtcctgcaac tttatccgcc 7860 tccatccagt
ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt 7920
ttgcgcaacg ttgttgccat tgctgcaggc atcgtggtgt cacgctcgtc gtttggtatg
7980 gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc
catgttgtgc 8040 aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca
gaagtaagtt ggccgcagtg 8100 ttatcactca tggttatggc agcactgcat
aattctctta ctgtcatgcc atccgtaaga 8160 tgcttttctg tgactggtga
gtactcaacc aagtcattct gagaatagtg tatgcggcga 8220 ccgagttgct
cttgcccggc gtcaacacgg gataataccg cgccacatag cagaacttta 8280
aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg
8340 ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc
atcttttact 8400 ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa
atgccgcaaa aaagggaata 8460 agggcgacac ggaaatgttg aatactcata
ctcttccttt ttcaatatta ttgaagcatt 8520 tatcagggtt attgtctcat
gagcggatac atatttgaat gtatttagaa aaataaacaa 8580 ataggggttc
cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt 8640
atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct tcaagaattc
8700 gagctcggta cccatcagcc aaaaagcatg cctgccacac aacatcaatt
tctggaaaac 8760 gctacactta attatttcta gtagaacagc tctttggttt
gccaaaaaga atcacctata 8820 gtggcatcta agcacaaaaa ggagaaaaaa
atcacaaaga aatgattgag aggcataata 8880 aaaattatca aaaaattatg
agttttacga tttcatcttt ttccaagttg aaatcatagg 8940 gtggctttaa
cacagtgaca aggaatgtgc atgctgccat tatggtgctc tgcctaaaat 9000
ggttggagcc ttgtcatgct acagagaaac tgtcatacag cagggggtgc caaatttcca
9060 tattttttta tatcattgag caggtgcaca gaagaccaga aagcactttc
tatcaggctg 9120 gccttcctct tcctttccag tatgaagcaa aaactgccaa
tgaaactagc aattgttaaa 9180 ttcctttttc aaacagtatt tgtgctatca
gaacatagtg cattcaaaag tctagcctga 9240 gagaacaacc cagttttatt
cattcctcct actacctctc tcattcccac tgtttgtgtt 9300 ctccctccca
ttttaattgt ctatctagtc caaactaagc acacgatcca gtccacatta 9360
aacaacatgt tttcacttta agtcaaatac aagacacctt taatatcagc ccttgttcat
9420 aatcgtgctt ctagtgactt aatgtacatg tcacactgta ctgttgggtt
ttgtgtctca 9480 tcatgaacaa tgttgtgaag gtattaagtg gagagtaagc
agaattagat tcctctaatg 9540 atgcacaccc acactaagag cagaaataat
attaaaaata gaaaaaaaag ttttacatga 9600 gatttcaaat acccaggtat
gagctgcagt ttcttcaagt taaagcatcg aggttgtcag 9660 ttacactatt
acaggaaaca tatgcagagt ttttatttta gtatattagt tttcacatat 9720
gtggaattac tattaaacta ttctttcttt tcaaatgctt accattgtaa atgagtttgt
9780 gactttgtgt aggtgagtgc acatgactct ggatgcctaa gaggactgaa
gaagttggag 9840 ttataggtag ttttattcta cttgactgtt cagtgctaaa
aatacaactg aggtccttta 9900 aactgctgtt catgaacttc ttaattgata
tatctcatga gatctctaaa ctatttttat 9960 tatgacacgt ttcaccattt
tcactgtaac gatttttatg ttttatatta atgtaactat 10020 atgacacttc
ccaaaatccc catattcaca attgaactgt ttcaaagttt taccttgact 10080
tatgggaaat gaaaacccac attttataat tttaaaatga aatgtttatt ttatatttct
10140 gcaaatttca caaggaaaga ttagtcactg gtgtgtgaga gcagaggagc
ataagagttc 10200 aggaatagaa tccattatga ttctggaggc aaggaagaac
tgatgccaag gtttcagtat 10260 aagagcagta tccactggaa aggataaagt
cactacatct gagcacagag caggacatct 10320 acataatgag tggtcactaa
tgggccactg ttacactgtt atatgtataa ggctcaagaa 10380 tgagcactga
ggctgtaagg tgtatgggtg aggacatcag gatgtaaacc cagctcaggt 10440
agaggactca gaggacagca cagtcagcat gaactaataa acatcagata agataaggca
10500 caagctcagc tatatagggt aagggatctt tgtaaatctg attgtgcatc
cagtctagtt 10560 caatgtgact taggaagccc agtcatatgc aaatctagag
aagactttag agtagaaatc 10620 tgaggctcac ctcacatacc agcaagcgag
tgaccagtta gtcttaaggc accacttctt 10680 agacatcatg gcttgggtgt
ggaccttgcc attcctgatg gcagctgccc aaagtaagac 10740 atcagaaaaa
agagttccaa ggggaattga agcagttcca tgaatactca ccttcctgtg 10800
ttcttttcac aggtgtccag gcagaggtgc agctggtgga gtcaggagcc gaagtgaaaa
10860 agcctggggc ttcagtgaag gtgtcctgca aggcctctgg atacacattc
actaattata 10920 ttatccactg ggtgaagcag gagcctggtc agggccttga
atggattgga tattttaatc 10980 cttacaatca tggtactaag tacaatgaga
agttcaaagg cagggccaca ctaactgcaa 11040 acaaatccat cagcacagcc
tacatggagc tcagcagcct gcgctctgag gacactgcgg 11100 tctactactg
tgcaagatca ggaccctatg cctggtttga cacctggggc caagggacca 11160
cggtcaccgt ctcctcaggt aagaatggcc actctagggc ctttgttttc tgctgctgcc
11220 tgtgggattt catgagcatt gcaaagttgt cctcgggaca tgttccgagg
ggacctgggc 11280 ggactggcca ggaggggacg ggcactgggg tgccttgagg
atctgggagc ctctgtggat 11340 tttccgatgc ctttggaaaa tgggactgag
gttgggtgcg tctgagacag taactcagcc 11400 tgggggcttg gtgaagatcg
ccgcacagca gcgagtccgt gaaatatctt atttagactt 11460 gtgaggtgcg
ctgtgtgtca atttacatct taaatccttt attggctgga aagagaattg 11520
ttggagtggg tgaatccagc caggagggac gcggggggat cca 11563 <210>
SEQ ID NO 41 <211> LENGTH: 11563 <212> TYPE: DNA
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: synthetic expression vector <220> FEATURE:
<223> OTHER INFORMATION: Nucleotide sequence of expression
vector HCVHQSp20 <400> SEQUENCE: 41 ctagagaggt ctggtggagc
ctgcaaaagt ccagctttca aaggaacaca gaagtatgtg 60 tatggaatat
tagaagatgt tgcttttact cttaagttgg ttcctaggaa aaatagttaa 120
atactgtgac tttaaaatgt gagagggttt tcaagtactc atttttttaa atgtccaaaa
180 tttttgtcaa tcaatttgag gtcttgtttg tgtagaactg acattactta
aagtttaacc 240 gaggaatggg agtgaggctc tctcataccc tattcagaac
tgacttttaa caataataaa 300 ttaagtttaa aatattttta aatgaattga
gcaatgttga gttggagtca agatggccga 360 tcagaaccag aacacctgca
gcagctggca ggaagcaggt catgtggcaa ggctatttgg 420 ggaagggaaa
ataaaaccac taggtaaact tgtagctgtg gtttgaagaa gtggttttga 480
aacactctgt ccagccccac caaaccgaaa gtccaggctg agcaaaacac cacctgggta
540 atttgcattt ctaaaataag ttgaggattc agccgaaact ggagaggtcc
tcttttaact 600 tattgagttc aaccttttaa ttttagcttg agtagttcta
gtttccccaa acttaagttt 660 atcgacttct aaaatgtatt taagctttct
ggggcaggcc aggcctgacc ttggctttgg 720 ggcagggagg gggctaaggt
gaggcaggtg gcgccagcca ggtgcacacc caatgcccat 780 gagcccagac
actggacgct gaacctcgcg gacagttaag aacccagggg cctctgcgcc 840
ctgggcccag ctctgtccca caccgcggtc acatggcacc acctctcttg cagcctccac
900 caagggccca tcggtcttcc ccctggcacc ctcctccaag agcacctctg
ggggcacagc 960 ggccctgggc tgcctggtca aggactactt ccccgaaccg
gtgacggtgt cgtggaactc 1020 aggcgccctg accagcggcg tgcacacctt
cccggctgtc ctacagtcct caggactcta 1080 ctccctcagc agcgtggtga
ccgtgccctc cagcagcttg ggcacccaga cctacatctg 1140 caacgtgaat
cacaagccca gcaacaccaa ggtggacaag agagttggtg agaggccagc 1200
acagggaggg agggtgtctg ctggaagcca ggctcagcgc tcctgcctgg acgcatcccg
1260 gctatgcagt cccagtccag ggcagcaagg caggccccgt ctgcctcttc
acccggaggc 1320 ctctgcccgc cccactcatg ctcagggaga gggtcttctg
gctttttccc caggctctgg 1380 gcaggcacag gctaggtgcc cctaacccag
gccctgcaca caaaggggca ggtgctgggc 1440 tcagacctgc caagagccat
atccgggagg accctgcccc tgacctaagc ccaccccaaa 1500 ggccaaactc
tccactccct cagctcggac accttctctc ctcccagatt ccagtaactc 1560
ccaatcttct ctctgcagag cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc
1620 caggtaagcc agcccaggcc tcgccctcca gctcaaggcg ggacaggtgc
cctagagtag 1680 cctgcatcca gggacaggcc ccagccgggt gctgacacgt
ccacctccat ctcttcctca 1740 gcacctgaac tcctgggggg accgtcagtc
ttcctcttcc ccccaaaacc caaggacacc 1800 ctcatgatct cccggacccc
tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 1860 cctgaggtca
agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag 1920
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac
1980 caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc
cctcccagcc 2040 cccatcgaga aaaccatctc caaagccaaa ggtgggaccc
gtggggtgcg agggccacat 2100 ggacagaggc cggctcggcc caccctctgc
cctgagagtg accgctgtac caacctctgt 2160 ccctacaggg cagccccgag
aaccacaggt gtacaccctg cccccatccc gggaggagat 2220 gaccaagaac
caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc 2280
cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct
2340 ggactccgac ggctccttct tcctctatag caagctcacc gtggacaaga
gcaggtggca 2400 gcaggggaac gtcttctcat gctccgtgat gcatgaggct
ctgcacaacc actacacgca 2460 gaagagcctc tccctgtccc cgggtaaatg
agtgcgacgg ccggcaagcc cccgctcccc 2520 gggctctcgc ggtcgcacga
ggatgcttgg cacgtacccc gtctacatac ttcccaggca 2580 cccagcatgg
aaataaagca cccaccactg ccctgggccc ctgcgagact gtgatggttc 2640
tttccacggg tcaggccgag tctgaggcct gagtggcatg agggaggcag agcgggtccc
2700 actgtcccca cactggccca ggctgtgcag gtgtgcctgg gccgcctagg
gtggggctca 2760 gccaggggct gccctcggca gggtggggga tttgccagcg
tggccctccc tccagcagca 2820 gctgccctgg gctgggccac gagaagccct
aggagcccct ggggacagac acacagcccc 2880 tgcctctgta ggagactgtc
ctgtcctgtg agcgccctgt cctccgaccc cgatgcccac 2940 tcgggggcat
gcctagtcca tgcgcgtagg gacaggccct ccctcaccca tctaccccca 3000
cggcactaac ccctggcagc cctgcccagc ctcgcacccg catggggaca caaccgactc
3060 cggggacatg cactctcggg ccctgtggag ggactggtgc agatgcccac
acacacactc 3120 agcccagacc cgttcaacaa accccgcact gaggttggtc
gagcgggagt gcggccagag 3180 cctgcctcgg ccgtcaggga ggactcccgg
gctcactcga aggaggtgcc accatttcag 3240 ctttggtagc ttttcttctt
cttttaaatt ttctaaagct cattaattgt ctttgatgtt 3300 tcttttgtga
tgacaataaa atatcctttt taagtcttgt acttcgtgat gggagccgcc 3360
ttcctgtgtc cacgcgcctc ctgcccccgg tgggaagcac ggtcaggagg aggctggtcc
3420 agctgcacct cgggggctcc ctgcactcgc cccccgcctc ctgcagccac
acgcattgcc 3480 cgagcgaccc tccctggccc ctgtcactac atggacccct
ggggcttctc ctcttttcta 3540 catggatgca gtttctcctc ctgctgggca
cggtgctgcc tgccctggtc actctgcggg 3600 ggacagggcc tccagggaaa
gctgggtcga ggctgggagc tggctcaggc tggccaggca 3660 gagccacagg
gagggccttc cagaaccaac catggtccga agcgagaggt gggtgtcaga 3720
tccagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa
3780 aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca
ttataagctg 3840 caataaacaa gttaacaaca acaattgcat tcattttatg
tttcaggttc agggggaggt 3900 gtgggaggtt ttttaaagca agtaaaacct
ctacaaatgt ggtatggctg attatgatct 3960 ctagtcaagg cactatacat
caaatattcc ttattaaccc ctttacaaat taaaaagcta 4020 aaggtacaca
atttttgagc atagttatta atagcagaca ctctatgcct gtgtggagta 4080
agaaaaaaca gtatgttatg attataactg ttatgcctac ttataaaggt tacagaatat
4140 ttttccataa ttttcttgta tagcagtgca gctttttcct ttgtggtgta
aatagcaaag 4200 caagcaagag ttctattact aaacacagca tgactcaaaa
aacttagcaa ttctgaagga 4260 aagtccttgg ggtcttctac ctttctcttc
ttttttggag gagtagaatg ttgagagtca 4320 gcagtagcct catcatcact
agatggcatt tcttctgagc aaaacaggtt ttcctcatta 4380 aaggcattcc
accactgctc ccattcatca gttccatagg ttggaatcta aaatacacaa 4440
acaattagaa tcagtagttt aacacattat acacttaaaa attttatatt taccttagag
4500 ctttaaatct ctgtaggtag tttgtccaat tatgtcacac cacagaagta
aggttccttc 4560 acaaagatcc ggaccaaagc ggccatcgtg cctccccact
cctgcagttc gggggcatgg 4620 atgcgcggat agccgctgct ggtttcctgg
atgccgacgg atttgcactg ccggtagaac 4680 tccgcgaggt cgtccagcct
caggcagcag ctgaaccaac tcgcgagggg atcgagcccg 4740 gggtgggcga
agaactccag catgagatcc ccgcgctgga ggatcatcca gccggcgtcc 4800
cggaaaacga ttccgaagcc caacctttca tagaaggcgg cggtggaatc gaaatctcgt
4860 gatggcaggt tgggcgtcgc ttggtcggtc atttcgaacc ccagagtccc
gctcagaaga 4920 actcgtcaag aaggcgatag aaggcgatgc gctgcgaatc
gggagcggcg ataccgtaaa 4980 gcacgaggaa gcggtcagcc cattcgccgc
caagctcttc agcaatatca cgggtagcca 5040 acgctatgtc ctgatagcgg
tccgccacac ccagccggcc acagtcgatg aatccagaaa 5100 agcggccatt
ttccaccatg atattcggca agcaggcatc gccatgggtc acgacgagat 5160
cctcgccgtc gggcatgcgc gccttgagcc tggcgaacag ttcggctggc gcgagcccct
5220 gatgctcttc gtccagatca tcctgatcga caagaccggc ttccatccga
gtacgtgctc 5280 gctcgatgcg atgtttcgct tggtggtcga atgggcaggt
agccggatca agcgtatgca 5340 gccgccgcat tgcatcagcc atgatggata
ctttctcggc aggagcaagg tgagatgaca 5400 ggagatcctg ccccggcact
tcgcccaata gcagccagtc ccttcccgct tcagtgacaa 5460 cgtcgagcac
agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct 5520
cgtcctgcag ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc
5580 cctgcgctga cagccggaac acggcggcat cagagcagcc gattgtctgt
tgtgcccagt 5640 catagccgaa tagcctctcc acccaagcgg ccggagaacc
tgcgtgcaat ccatcttgtt 5700 caatcatgcg aaacgatcct catcctgtct
cttgatcaga tcttgatccc ctgcgccatc 5760 agatccttgg cggcaagaaa
gccatccagt ttactttgca gggcttccca accttaccag 5820 agggcgcccc
agctggcaat tccggttcgc ttgctgtcca taaaaccgcc cagtctagct 5880
atcgccatgt aagcccactg caagctacct gctttctctt tgcgcttgcg ttttcccttg
5940 tccagatagc ccagtagctg acattcatcc ggggtcagca ccgtttctgc
ggactggctt 6000 tctacgtgtt ccgcttcctt tagcagccct tgcgccctga
gtgcttgcgg cagcgtgaag 6060 ctttttgcaa aagcctaggc ctccaaaaaa
gcctcctcac tacttctgga atagctcaga 6120 ggccgaggcg gcctcggcct
ctgcataaat aaaaaaaatt agtcagccat ggggcggaga 6180 atgggcggaa
ctgggcggag ttaggggcgg gatgggcgga gttaggggcg ggactatggt 6240
tgctgactaa ttgagatgca tgctttgcat acttctgcct gctggggagc ctggggactt
6300 tccacacctg gttgctgact aattgagatg catgctttgc atacttctgc
ctgctgggga 6360 gcctggggac tttccacacc ctaactgaca cacattccac
agctgcctcg cgcgtttcgg 6420 tgatgacggt gaaaacctct gacacatgca
gctcccggag acggtcacag cttgtctgta 6480 agcggatgcc gggagcagac
aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg 6540 gggcgcagcc
atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg 6600
gcatcagagc agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc
6660 gtaaggagaa aataccgcat caggcgctct tccgcttcct cgctcactga
ctcgctgcgc 6720 tcggtcgttc ggctgcggcg agcggtatca gctcactcaa
aggcggtaat acggttatcc 6780 acagaatcag gggataacgc aggaaagaac
atgtgagcaa aaggccagca aaaggccagg 6840 aaccgtaaaa aggccgcgtt
gctggcgttt ttccataggc tccgcccccc tgacgagcat 6900 cacaaaaatc
gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag 6960
gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga
7020 tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc
acgctgtagg 7080 tatctcagtt cggtgtaggt cgttcgctcc aagctgggct
gtgtgcacga accccccgtt 7140 cagcccgacc gctgcgcctt atccggtaac
tatcgtcttg agtccaaccc ggtaagacac 7200 gacttatcgc cactggcagc
agccactggt aacaggatta gcagagcgag gtatgtaggc 7260 ggtgctacag
agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt 7320
ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc
7380 ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca
gattacgcgc 7440 agaaaaaaag gatctcaaga agatcctttg atcttttcta
cggggtctga cgctcagtgg 7500 aacgaaaact cacgttaagg gattttggtc
atgagattat caaaaaggat cttcacctag 7560 atccttttaa attaaaaatg
aagttttaaa tcaatctaaa gtatatatga gtaaacttgg 7620 tctgacagtt
accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt 7680
tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca
7740 tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc
agatttatca 7800 gcaataaacc agccagccgg aagggccgag cgcagaagtg
gtcctgcaac tttatccgcc 7860 tccatccagt ctattaattg ttgccgggaa
gctagagtaa gtagttcgcc agttaatagt 7920 ttgcgcaacg ttgttgccat
tgctgcaggc atcgtggtgt cacgctcgtc gtttggtatg 7980 gcttcattca
gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc 8040
aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg
8100 ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc
atccgtaaga 8160 tgcttttctg tgactggtga gtactcaacc aagtcattct
gagaatagtg tatgcggcga 8220 ccgagttgct cttgcccggc gtcaacacgg
gataataccg cgccacatag cagaacttta 8280 aaagtgctca tcattggaaa
acgttcttcg gggcgaaaac tctcaaggat cttaccgctg 8340 ttgagatcca
gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact 8400
ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata
8460 agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta
ttgaagcatt 8520 tatcagggtt attgtctcat gagcggatac atatttgaat
gtatttagaa aaataaacaa 8580 ataggggttc cgcgcacatt tccccgaaaa
gtgccacctg acgtctaaga aaccattatt 8640 atcatgacat taacctataa
aaataggcgt atcacgaggc cctttcgtct tcaagaattc 8700 gagctcggta
cccatcagcc aaaaagcatg cctgccacac aacatcaatt tctggaaaac 8760
gctacactta attatttcta gtagaacagc tctttggttt gccaaaaaga atcacctata
8820 gtggcatcta agcacaaaaa ggagaaaaaa atcacaaaga aatgattgag
aggcataata 8880 aaaattatca aaaaattatg agttttacga tttcatcttt
ttccaagttg aaatcatagg 8940 gtggctttaa cacagtgaca aggaatgtgc
atgctgccat tatggtgctc tgcctaaaat 9000 ggttggagcc ttgtcatgct
acagagaaac tgtcatacag cagggggtgc caaatttcca 9060 tattttttta
tatcattgag caggtgcaca gaagaccaga aagcactttc tatcaggctg 9120
gccttcctct tcctttccag tatgaagcaa aaactgccaa tgaaactagc aattgttaaa
9180 ttcctttttc aaacagtatt tgtgctatca gaacatagtg cattcaaaag
tctagcctga 9240 gagaacaacc cagttttatt cattcctcct actacctctc
tcattcccac tgtttgtgtt 9300 ctccctccca ttttaattgt ctatctagtc
caaactaagc acacgatcca gtccacatta 9360 aacaacatgt tttcacttta
agtcaaatac aagacacctt taatatcagc ccttgttcat 9420 aatcgtgctt
ctagtgactt aatgtacatg tcacactgta ctgttgggtt ttgtgtctca 9480
tcatgaacaa tgttgtgaag gtattaagtg gagagtaagc agaattagat tcctctaatg
9540 atgcacaccc acactaagag cagaaataat attaaaaata gaaaaaaaag
ttttacatga 9600 gatttcaaat acccaggtat gagctgcagt ttcttcaagt
taaagcatcg aggttgtcag 9660 ttacactatt acaggaaaca tatgcagagt
ttttatttta gtatattagt tttcacatat 9720 gtggaattac tattaaacta
ttctttcttt tcaaatgctt accattgtaa atgagtttgt 9780 gactttgtgt
aggtgagtgc acatgactct ggatgcctaa gaggactgaa gaagttggag 9840
ttataggtag ttttattcta cttgactgtt cagtgctaaa aatacaactg aggtccttta
9900 aactgctgtt catgaacttc ttaattgata tatctcatga gatctctaaa
ctatttttat 9960 tatgacacgt ttcaccattt tcactgtaac gatttttatg
ttttatatta atgtaactat 10020 atgacacttc ccaaaatccc catattcaca
attgaactgt ttcaaagttt taccttgact 10080 tatgggaaat gaaaacccac
attttataat tttaaaatga aatgtttatt ttatatttct 10140 gcaaatttca
caaggaaaga ttagtcactg gtgtgtgaga gcagaggagc ataagagttc 10200
aggaatagaa tccattatga ttctggaggc aaggaagaac tgatgccaag gtttcagtat
10260 aagagcagta tccactggaa aggataaagt cactacatct gagcacagag
caggacatct 10320 acataatgag tggtcactaa tgggccactg ttacactgtt
atatgtataa ggctcaagaa 10380 tgagcactga ggctgtaagg tgtatgggtg
aggacatcag gatgtaaacc cagctcaggt 10440 agaggactca gaggacagca
cagtcagcat gaactaataa acatcagata agataaggca 10500 caagctcagc
tatatagggt aagggatctt tgtaaatctg attgtgcatc cagtctagtt 10560
caatgtgact taggaagccc agtcatatgc aaatctagag aagactttag agtagaaatc
10620 tgaggctcac ctcacatacc agcaagcgag tgaccagtta gtcttaaggc
accacttctt 10680 agacatcatg gcttgggtgt ggaccttgcc attcctgatg
gcagctgccc aaagtaagac 10740 atcagaaaaa agagttccaa ggggaattga
agcagttcca tgaatactca ccttcctgtg 10800 ttcttttcac aggtgtccag
gcacaggtgc agctggtgga gtcaggagcc gaagtgaaaa 10860 agcctggggc
ttcagtgaag gtgtcctgca aggcctctgg atacacattc actaattata 10920
ttatccactg ggtgaagcag gagcctggtc agggccttga atggattgga tattttaatc
10980 cttacaatca tggtactaag tacaatgaga agttcaaagg cagggccaca
ctaactgcaa 11040 acaaatccat cagcacagcc tacatggagc tcagcagcct
gcgctctgag gacactgcgg 11100 tctactactg tgcaagatca ggaccctatg
cctggtttga cacctggggc caagggacca 11160 cggtcaccgt ctcctcaggt
aagaatggcc actctagggc ctttgttttc tgctgctgcc 11220 tgtgggattt
catgagcatt gcaaagttgt cctcgggaca tgttccgagg ggacctgggc 11280
ggactggcca ggaggggacg ggcactgggg tgccttgagg atctgggagc ctctgtggat
11340 tttccgatgc ctttggaaaa tgggactgag gttgggtgcg tctgagacag
taactcagcc 11400 tgggggcttg gtgaagatcg ccgcacagca gcgagtccgt
gaaatatctt atttagactt 11460 gtgaggtgcg ctgtgtgtca atttacatct
taaatccttt attggctgga aagagaattg 11520 ttggagtggg tgaatccagc
caggagggac gcggggggat cca 11563 <210> SEQ ID NO 42
<211> LENGTH: 33 <212> TYPE: DNA <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
synthetic primer construct <220> FEATURE: <223> OTHER
INFORMATION: HuCD45LC-Mlu Primer <400> SEQUENCE: 42
aaaacgcgtt gtgacattct gctgacccag tct 33 <210> SEQ ID NO 43
<211> LENGTH: 31 <212> TYPE: DNA <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
synthetic primer construct <220> FEATURE: <223> OTHER
INFORMATION: HuCD45LC-Hind Primer <400> SEQUENCE: 43
aaaaaagctt ggtcccctgg ccgaacgtga a 31 <210> SEQ ID NO 44
<211> LENGTH: 27 <212> TYPE: DNA <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
synthetic primer construct <220> FEATURE: <223> OTHER
INFORMATION: HuCD45HCEup Primer <400> SEQUENCE: 44 caggcagagg
tgcagctggt ggagtca 27 <210> SEQ ID NO 45 <211> LENGTH:
27 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: synthetic
primer construct <220> FEATURE: <223> OTHER
INFORMATION: HuCD45HCQup Primer <400> SEQUENCE: 45 caggcacagg
tgcagctggt ggagtca 27 <210> SEQ ID NO 46 <211> LENGTH:
29 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: synthetic
primer construct <220> FEATURE: <223> OTHER
INFORMATION: HuCD45HClo Primer <400> SEQUENCE: 46 aaatccttct
agaactcacc tgaggagac 29 <210> SEQ ID NO 47 <211>
LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: recombinant
protein <220> FEATURE: <223> OTHER INFORMATION: Leader
Sequence <400> SEQUENCE: 47 Met Asp Trp Thr Trp Arg Val Phe
Cys Leu Leu Ala Val Val Ala Pro 1 5 10 15 Gly Ala His Ser 20
<210> SEQ ID NO 48 <211> LENGTH: 19 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: recombinant protein <220>
FEATURE: <223> OTHER INFORMATION: Leader Sequence <400>
SEQUENCE: 48 Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala
Ala Gln Ser 1 5 10 15 Val Gln Ala <210> SEQ ID NO 49
<211> LENGTH: 35 <212> TYPE: DNA <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
synthetic primer construct <220> FEATURE: <223> OTHER
INFORMATION: aCD45H-N73D Primer <400> SEQUENCE: 49 gccacactaa
ctgcagacaa atccatcagc acagc 35
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 49 <210>
SEQ ID NO 1 <211> LENGTH: 107 <212> TYPE: PRT
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: chimeric human-murine construct <220>
FEATURE: <223> OTHER INFORMATION: Part of the amino acid
sequence of chimeric light chain <400> SEQUENCE: 1 Asp Ile
Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 1 5 10 15
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser 20
25 30 Ile Gln Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu
Ile 35 40 45 Arg Ser Ser Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg
Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile
Asn Ser Val Glu Ser 65 70 75 80 Glu Asp Ile Ala Asp Tyr Tyr Cys Gln
Gln Ser Asn Thr Trp Pro Phe 85 90 95 Thr Phe Gly Ser Gly Thr Lys
Leu Glu Ile Lys 100 105 <210> SEQ ID NO 2 <211> LENGTH:
118 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
human-murine construct <220> FEATURE: <223> OTHER
INFORMATION: Part of the amino acid sequence of chimeric heavy
chain <400> SEQUENCE: 2 Glu Val Gln Leu Gln Gln Ser Gly Pro
Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys
Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ile Ile His Trp Val
Lys Gln Glu Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe
Asn Pro Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys
Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 65 70
75 80 Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr
Cys 85 90 95 Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp Gly
Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> SEQ
ID NO 3 <211> LENGTH: 214 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: chimeric human-murine construct <220> FEATURE:
<223> OTHER INFORMATION: Amino acid sequence of chimeric
light chain <400> SEQUENCE: 3 Asp Ile Leu Leu Thr Gln Ser Pro
Ala Ile Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Val Ser Phe Ser
Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser 20 25 30 Ile Gln Trp Tyr
Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 35 40 45 Arg Ser
Ser Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 65
70 75 80 Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Thr Trp
Pro Phe 85 90 95 Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg
Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu
Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val
Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val
Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185
190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> SEQ ID NO 4
<211> LENGTH: 448 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
chimeric human-murine construct <220> FEATURE: <223>
OTHER INFORMATION: Amino acid sequence of chimeric heavy chain
<400> SEQUENCE: 4 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu
Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ile Ile His Trp Val Lys Gln
Glu Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe Asn Pro
Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Arg
Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 65 70 75 80 Met
Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 85 90
95 Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp Gly Gln Gly Thr
100 105 110 Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly
Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn
Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215
220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340
345 350 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445
<210> SEQ ID NO 5 <211> LENGTH: 321 <212> TYPE:
DNA <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric human-murine construct
<220> FEATURE: <223> OTHER INFORMATION: Nucleotide
sequence encoding a polypeptide of SEQ ID NO:1 <400>
SEQUENCE: 5 gacattctgc tgacccagtc tccagccatc ctgtctgtga gtccaggaga
aagagtcagt 60 ttctcctgca gggccagtca gaacattggc acaagcatac
agtggtatca acaaagaaca 120 aatggttctc caaggcttct cataaggtct
tcttctgagt ctatctctgg gatcccttcc 180 aggtttagtg gcagtggatc
agggacagat tttactctta gcatcaacag tgtggagtct 240 gaagatattg
cagattatta ctgtcaacaa agtaatacct ggccattcac gttcggctcg 300
gggaccaagc ttgaaatcaa a 321 <210> SEQ ID NO 6 <211>
LENGTH: 354 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
human-murine construct <220> FEATURE: <223> OTHER
INFORMATION: Nucleotide sequence encoding a polypeptide of SEQ ID
NO:2 <400> SEQUENCE: 6 gaggtgcagc tgcagcagtc aggacctgaa
ctggtaaagc ctggggcttc agtgaagatg 60 tcctgcaagg cctctggata
cacattcact aattatatta tccactgggt gaagcaggag 120 cctggtcagg
gccttgaatg gattggatat tttaatcctt acaatcatgg tactaagtac 180
aatgagaagt tcaaaggcag ggccacacta actgcagaca aatcctccaa cacagcctac
240 atggacctca gcagcctgac ctctgaggac tctgcgatct actactgtgc
aagatcagga 300 ccctatgcct ggtttgacac ctggggccaa gggaccacgg
tcaccgtctc ctca 354 <210> SEQ ID NO 7 <211> LENGTH: 107
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: chimeric human-murine
construct <220> FEATURE: <223> OTHER INFORMATION: Part
of amino acid sequence of humanised light chain designated humV2
(humV2 = VLm) <400> SEQUENCE: 7 Asp Ile Leu Leu Thr Gln Ser
Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe
Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser 20 25 30 Ile Gln Trp
Tyr Gln Gln Lys Thr Asn Gly Ala Pro Arg Leu Leu Ile 35 40 45 Arg
Ser Ser Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55
60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Thr Trp
Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100
105 <210> SEQ ID NO 8 <211> LENGTH: 107 <212>
TYPE: PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric human-murine construct
<220> FEATURE: <223> OTHER INFORMATION: Part of amino
acid sequence of humanised light chain designated humV1 (humV1 =
VLh) <400> SEQUENCE: 8 Asp Ile Leu Leu Thr Gln Ser Pro Ala
Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys
Arg Ala Ser Gln Asn Ile Gly Thr Ser 20 25 30 Ile Gln Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Arg Ser Ser
Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70
75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro
Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105
<210> SEQ ID NO 9 <211> LENGTH: 118 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric human-murine construct
<220> FEATURE: <223> OTHER INFORMATION: Part of amino
acid sequence of humanised heavychain designated VHE <400>
SEQUENCE: 9 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro
Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
Phe Thr Asn Tyr 20 25 30 Ile Ile His Trp Val Lys Gln Glu Pro Gly
Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe Asn Pro Tyr Asn His
Gly Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Arg Ala Thr Leu
Thr Ala Asn Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser
Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg
Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp Gly Gln Gly Thr 100 105 110
Thr Val Thr Val Ser Ser 115 <210> SEQ ID NO 10 <211>
LENGTH: 118 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
human-murine construct <220> FEATURE: <223> OTHER
INFORMATION: Part of amino acid sequence of humanised heavy chain
designated VHQ <400> SEQUENCE: 10 Gln Val Gln Leu Val Glu Ser
Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ile Ile His
Trp Val Lys Gln Glu Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly
Tyr Phe Asn Pro Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe 50 55
60 Lys Gly Arg Ala Thr Leu Thr Ala Asn Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp
Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210>
SEQ ID NO 11 <211> LENGTH: 354 <212> TYPE: DNA
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: chimeric human-murine construct <220>
FEATURE: <223> OTHER INFORMATION: Nucleotide sequence
encoding amino acid sequence SEQ ID NO:9 <400> SEQUENCE: 11
gaggtgcagc tggtggagtc aggagccgaa gtgaaaaagc ctggggcttc agtgaaggtg
60 tcctgcaagg cctctggata cacattcact aattatatta tccactgggt
gaagcaggag 120 cctggtcagg gccttgaatg gattggatat tttaatcctt
acaatcatgg tactaagtac 180 aatgagaagt tcaaaggcag ggccacacta
actgcaaaca aatccatcag cacagcctac 240 atggagctca gcagcctgcg
ctctgaggac actgcggtct actactgtgc aagatcagga 300 ccctatgcct
ggtttgacac ctggggccaa gggaccacgg tcaccgtctc ctca 354 <210>
SEQ ID NO 12 <211> LENGTH: 354 <212> TYPE: DNA
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: chimeric human-murine construct <220>
FEATURE: <223> OTHER INFORMATION: Nucleotide sequence
encoding amino acid sequence SEQ ID NO:10 <400> SEQUENCE: 12
caggtgcagc tggtggagtc aggagccgaa gtgaaaaagc ctggggcttc agtgaaggtg
60 tcctgcaagg cctctggata cacattcact aattatatta tccactgggt
gaagcaggag 120 cctggtcagg gccttgaatg gattggatat tttaatcctt
acaatcatgg tactaagtac 180 aatgagaagt tcaaaggcag ggccacacta
actgcaaaca aatccatcag cacagcctac 240 atggagctca gcagcctgcg
ctctgaggac actgcggtct actactgtgc aagatcagga 300 ccctatgcct
ggtttgacac ctggggccaa gggaccacgg tcaccgtctc ctca 354 <210>
SEQ ID NO 13 <211> LENGTH: 321 <212> TYPE: DNA
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: chimeric human-murine construct <220>
FEATURE: <223> OTHER INFORMATION: Nucleotide sequence
encoding amino acid sequence SEQ ID NO:7 <400> SEQUENCE: 13
gacattctgc tgacccagtc tccagccacc ctgtctctga gtccaggaga aagagccact
60 ttctcctgca gggccagtca gaacattggc acaagcatac agtggtatca
acaaaaaaca 120 aatggtgctc caaggcttct cataaggtct tcttctgagt
ctatctctgg gatcccttcc 180 aggtttagtg gcagtggatc agggacagat
tttactctta ccatcagcag tctggagcct 240 gaagattttg cagtgtatta
ctgtcaacaa agtaatacct ggccattcac gttcggccag 300 gggaccaagc
tggagatcaa a 321 <210> SEQ ID NO 14 <211> LENGTH: 321
<212> TYPE: DNA <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: chimeric human-murine
construct
<220> FEATURE: <223> OTHER INFORMATION: Nucleotide
sequence encoding amino acid sequence SEQ ID NO:8 <400>
SEQUENCE: 14 gacattctgc tgacccagtc tccagccacc ctgtctctga gtccaggaga
aagagccact 60 ctctcctgca gggccagtca gaacattggc acaagcatac
agtggtatca acaaaaacca 120 ggtcaggctc caaggcttct cataaggtct
tcttctgagt ctatctctgg gatcccttcc 180 aggtttagtg gcagtggatc
agggacagat tttactctta ccatcagcag tctggagcct 240 gaagattttg
cagtgtatta ctgtcaacaa agtaatacct ggccattcac gttcggccag 300
gggaccaagc tggagatcaa a 321 <210> SEQ ID NO 15 <211>
LENGTH: 8687 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: synthetic
expression vector <220> FEATURE: <223> OTHER
INFORMATION: Nucleotide sequence of the expression vector HCMV-G1
HuA6-VHQ (Complete DNA Sequence of a humanised heavy chain
expression vector comprising SEQ ID NO:12 (VHQ) from 3921-4274)
<400> SEQUENCE: 15 agctttttgc aaaagcctag gcctccaaaa
aagcctcctc actacttctg gaatagctca 60 gaggccgagg cggcctcggc
ctctgcataa ataaaaaaaa ttagtcagcc atggggcgga 120 gaatgggcgg
aactgggcgg agttaggggc gggatgggcg gagttagggg cgggactatg 180
gttgctgact aattgagatg catgctttgc atacttctgc ctgctgggga gcctggttgc
240 tgactaattg agatgcatgc tttgcatact tctgcctgct ggggagcctg
gggactttcc 300 acaccctaac tgacacacat tccacagctg cctcgcgcgt
ttcggtgatg acggtgaaaa 360 cctctgacac atgcagctcc cggagacggt
cacagcttgt ctgtaagcgg atgccgggag 420 cagacaagcc cgtcagggcg
cgtcagcggg tgttggcggg tgtcggggcg cagccatgac 480 ccagtcacgt
agcgatagcg gagtgtatac tggcttaact atgcggcatc agagcagatt 540
gtactgagag tgcaccatat gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac
600 cgcatcaggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt
cgttcggctg 660 cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt
tatccacaga atcaggggat 720 aacgcaggaa agaacatgtg agcaaaaggc
cagcaaaagg ccaggaaccg taaaaaggcc 780 gcgttgctgg cgtttttcca
taggctccgc ccccctgacg agcatcacaa aaatcgacgc 840 tcaagtcaga
ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga 900
agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt
960 ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct
cagttcggtg 1020 taggtcgttc gctccaagct gggctgtgtg cacgaacccc
ccgttcagcc cgaccgctgc 1080 gccttatccg gtaactatcg tcttgagtcc
aacccggtaa gacacgactt atcgccactg 1140 gcagcagcca ctggtaacag
gattagcaga gcgaggtatg taggcggtgc tacagagttc 1200 ttgaagtggt
ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg 1260
ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc
1320 gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa
aaaaggatct 1380 caagaagatc ctttgatctt ttctacgggg tctgacgctc
agtggaacga aaactcacgt 1440 taagggattt tggtcatgag attatcaaaa
aggatcttca cctagatcct tttaaattaa 1500 aaatgaagtt ttaaatcaat
ctaaagtata tatgagtaaa cttggtctga cagttaccaa 1560 tgcttaatca
gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc 1620
tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct
1680 gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat
aaaccagcca 1740 gccggaaggg ccgagcgcag aagtggtcct gcaactttat
ccgcctccat ccagtctatt 1800 aattgttgcc gggaagctag agtaagtagt
tcgccagtta atagtttgcg caacgttgtt 1860 gccattgctg caggcatcgt
ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc 1920 ggttcccaac
gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc 1980
tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt
2040 atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt
ttctgtgact 2100 ggtgagtact caaccaagtc attctgagaa tagtgtatgc
ggcgaccgag ttgctcttgc 2160 ccggcgtcaa cacgggataa taccgcgcca
catagcagaa ctttaaaagt gctcatcatt 2220 ggaaaacgtt cttcggggcg
aaaactctca aggatcttac cgctgttgag atccagttcg 2280 atgtaaccca
ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct 2340
gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa
2400 tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca
gggttattgt 2460 ctcatgagcg gatacatatt tgaatgtatt tagaaaaata
aacaaatagg ggttccgcgc 2520 acatttcccc gaaaagtgcc acctgacgtc
taagaaacca ttattatcat gacattaacc 2580 tataaaaata ggcgtatcac
gaggcccttt cgtcttcaag aattcagctt ggctgcagtg 2640 aataataaaa
tgtgtgtttg tccgaaatac gcgttttgag atttctgtcg ccgactaaat 2700
tcatgtcgcg cgatagtggt gtttatcgcc gatagagatg gcgatattgg aaaaatcgat
2760 atttgaaaat atggcatatt gaaaatgtcg ccgatgtgag tttctgtgta
actgatatcg 2820 ccatttttcc aaaagtgatt tttgggcata cgcgatatct
ggcgatagcg cttatatcgt 2880 ttacggggga tggcgataga cgactttggt
gacttgggcg attctgtgtg tcgcaaatat 2940 cgcagtttcg atataggtga
cagacgatat gaggctatat cgccgataga ggcgacatca 3000 agctggcaca
tggccaatgc atatcgatct atacattgaa tcaatattgg ccattagcca 3060
tattattcat tggttatata gcataaatca atattggcta ttggccattg catacgttgt
3120 atccatatca taatatgtac atttatattg gctcatgtcc aacattaccg
ccatgttgac 3180 attgattatt gactagttat taatagtaat caattacggg
gtcattagtt catagcccat 3240 atatggagtt ccgcgttaca taacttacgg
taaatggccc gcctggctga ccgcccaacg 3300 acccccgccc attgacgtca
ataatgacgt atgttcccat agtaacgcca atagggactt 3360 tccattgacg
tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag 3420
tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc
3480 attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc
tacgtattag 3540 tcatcgctat taccatggtg atgcggtttt ggcagtacat
caatgggcgt ggatagcggt 3600 ttgactcacg gggatttcca agtctccacc
ccattgacgt caatgggagt ttgttttggc 3660 accaaaatca acgggacttt
ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg 3720 gcggtaggcg
tgtacggtgg gaggtctata taagcagagc tcgtttagtg aaccgtcaga 3780
tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg gaccgatcca
3840 gcctccgcaa gcttgccgcc accatggact ggacctggag ggtgttctgc
ctgctggccg 3900 tggcccccgg cgcccacagc caggtgcagc tggtggagtc
aggagccgaa gtgaaaaagc 3960 ctggggcttc agtgaaggtg tcctgcaagg
cctctggata cacattcact aattatatta 4020 tccactgggt gaagcaggag
cctggtcagg gccttgaatg gattggatat tttaatcctt 4080 acaatcatgg
tactaagtac aatgagaagt tcaaaggcag ggccacacta actgcaaaca 4140
aatccatcag cacagcctac atggagctca gcagcctgcg ctctgaggac actgcggtct
4200 actactgtgc aagatcagga ccctatgcct ggtttgacac ctggggccaa
gggaccacgg 4260 tcaccgtctc ctcaggtgag ttctagaagg atcccaagct
agctttctgg ggcaggccag 4320 gcctgacctt ggctttgggg cagggagggg
gctaaggtga ggcaggtggc gccagccagg 4380 tgcacaccca atgcccatga
gcccagacac tggacgctga acctcgcgga cagttaagaa 4440 cccaggggcc
tctgcgccct gggcccagct ctgtcccaca ccgcggtcac atggcaccac 4500
ctctcttgca gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag
4560 cacctctggg ggcacagcgg ccctgggctg cctggtcaag gactacttcc
ccgaaccggt 4620 gacggtgtcg tggaactcag gcgccctgac cagcggcgtg
cacaccttcc cggctgtcct 4680 acagtcctca ggactctact ccctcagcag
cgtggtgacc gtgccctcca gcagcttggg 4740 cacccagacc tacatctgca
acgtgaatca caagcccagc aacaccaagg tggacaagaa 4800 agttggtgag
aggccagcac agggagggag ggtgtctgct ggaagccagg ctcagcgctc 4860
ctgcctggac gcatcccggc tatgcagccc cagtccaggg cagcaaggca ggccccgtct
4920 gcctcttcac ccggaggcct ctgcccgccc cactcatgct cagggagagg
gtcttctggc 4980 tttttcccca ggctctgggc aggcacaggc taggtgcccc
taacccaggc cctgcacaca 5040 aaggggcagg tgctgggctc agacctgcca
agagccatat ccgggaggac cctgcccctg 5100 acctaagccc accccaaagg
ccaaactctc cactccctca gctcggacac cttctctcct 5160 cccagattcc
agtaactccc aatcttctct ctgcagagcc caaatcttgt gacaaaactc 5220
acacatgccc accgtgccca ggtaagccag cccaggcctc gccctccagc tcaaggcggg
5280 acaggtgccc tagagtagcc tgcatccagg gacaggcccc agccgggtgc
tgacacgtcc 5340 acctccatct cttcctcagc acctgaactc ctggggggac
cgtcagtctt cctcttcccc 5400 ccaaaaccca aggacaccct catgatctcc
cggacccctg aggtcacatg cgtggtggtg 5460 gacgtgagcc acgaagaccc
tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 5520 cataatgcca
agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 5580
gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc
5640 aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg
tgggacccgt 5700 ggggtgcgag ggccacatgg acagaggccg gctcggccca
ccctctgccc tgagagtgac 5760 cgctgtacca acctctgtcc ctacagggca
gccccgagaa ccacaggtgt acaccctgcc 5820 cccatcccgg gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt 5880 ctatcccagc
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa 5940
gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
6000 ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct 6060 gcacaaccac tacacgcaga agagcctctc cctgtctccg
ggtaaatgag tgcgacggcc 6120 ggcaagcccc cgctccccgg gctctcgcgg
tcgcacgagg atgcttggca cgtaccccct 6180 gtacatactt cccgggcgcc
cagcatggaa ataaagcacc cagcgctgcc ctgggcccct 6240 gcgagactgt
gatggttctt tccacgggtc aggccgagtc tgaggcctga gtggcatgag 6300
atctgatatc atcgatgaat tcgagctcgg tacccgggga tcgatccaga catgataaga
6360 tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg
ctttatttgt 6420 gaaatttgtg atgctattgc tttatttgta accattataa
gctgcaataa acaagttaac 6480 aacaacaatt gcattcattt tatgtttcag
gttcaggggg aggtgtggga ggttttttaa 6540
agcaagtaaa acctctacaa atgtggtatg gctgattatg atctctagtc aaggcactat
6600 acatcaaata ttccttatta acccctttac aaattaaaaa gctaaaggta
cacaattttt 6660 gagcatagtt attaatagca gacactctat gcctgtgtgg
agtaagaaaa aacagtatgt 6720 tatgattata actgttatgc ctacttataa
aggttacaga atatttttcc ataattttct 6780 tgtatagcag tgcagctttt
tcctttgtgg tgtaaatagc aaagcaagca agagttctat 6840 tactaaacac
agcatgactc aaaaaactta gcaattctga aggaaagtcc ttggggtctt 6900
ctacctttct cttctttttt ggaggagtag aatgttgaga gtcagcagta gcctcatcat
6960 cactagatgg catttcttct gagcaaaaca ggttttcctc attaaaggca
ttccaccact 7020 gctcccattc atcagttcca taggttggaa tctaaaatac
acaaacaatt agaatcagta 7080 gtttaacaca ttatacactt aaaaatttta
tatttacctt agagctttaa atctctgtag 7140 gtagtttgtc caattatgtc
acaccacaga agtaaggttc cttcacaaag atccgggacc 7200 aaagcggcca
tcgtgcctcc ccactcctgc agttcggggg catggatgcg cggatagccg 7260
ctgctggttt cctggatgcc gacggatttg cactgccggt agaactccgc gaggtcgtcc
7320 agcctcaggc agcagctgaa ccaactcgcg aggggatcga gcccggggtg
ggcgaagaac 7380 tccagcatga gatccccgcg ctggaggatc atccagccgg
cgtcccggaa aacgattccg 7440 aagcccaacc tttcatagaa ggcggcggtg
gaatcgaaat ctcgtgatgg caggttgggc 7500 gtcgcttggt cggtcatttc
gaaccccaga gtcccgctca gaagaactcg tcaagaaggc 7560 gatagaaggc
gatgcgctgc gaatcgggag cggcgatacc gtaaagcacg aggaagcggt 7620
cagcccattc gccgccaagc tcttcagcaa tatcacgggt agccaacgct atgtcctgat
7680 agcggtccgc cacacccagc cggccacagt cgatgaatcc agaaaagcgg
ccattttcca 7740 ccatgatatt cggcaagcag gcatcgccat gggtcacgac
gagatcctcg ccgtcgggca 7800 tgcgcgcctt gagcctggcg aacagttcgg
ctggcgcgag cccctgatgc tcttcgtcca 7860 gatcatcctg atcgacaaga
ccggcttcca tccgagtacg tgctcgctcg atgcgatgtt 7920 tcgcttggtg
gtcgaatggg caggtagccg gatcaagcgt atgcagccgc cgcattgcat 7980
cagccatgat ggatactttc tcggcaggag caaggtgaga tgacaggaga tcctgccccg
8040 gcacttcgcc caatagcagc cagtcccttc ccgcttcagt gacaacgtcg
agcacagctg 8100 cgcaaggaac gcccgtcgtg gccagccacg atagccgcgc
tgcctcgtcc tgcagttcat 8160 tcagggcacc ggacaggtcg gtcttgacaa
aaagaaccgg gcgcccctgc gctgacagcc 8220 ggaacacggc ggcatcagag
cagccgattg tctgttgtgc ccagtcatag ccgaatagcc 8280 tctccaccca
agcggccgga gaacctgcgt gcaatccatc ttgttcaatc atgcgaaacg 8340
atcctcatcc tgtctcttga tcagatcttg atcccctgcg ccatcagatc cttggcggca
8400 agaaagccat ccagtttact ttgcagggct tcccaacctt accagagggc
gccccagctg 8460 gcaattccgg ttcgcttgct gtccataaaa ccgcccagtc
tagctatcgc catgtaagcc 8520 cactgcaagc tacctgcttt ctctttgcgc
ttgcgttttc ccttgtccag atagcccagt 8580 agctgacatt catccggggt
cagcaccgtt tctgcggact ggctttctac gtgttccgct 8640 tcctttagca
gcccttgcgc cctgagtgct tgcggcagcg tgaagct 8687 <210> SEQ ID NO
16 <211> LENGTH: 8687 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic expression vector <220> FEATURE:
<223> OTHER INFORMATION: Nucleotide sequence of the
expression vector HCMV-G1 HuA6-VHE (Complete DNA Sequence of a
humanised heavy chain expression vector comprising SEQ ID NO: 11
(VHE) from 3921-4274) <400> SEQUENCE: 16 agctttttgc
aaaagcctag gcctccaaaa aagcctcctc actacttctg gaatagctca 60
gaggccgagg cggcctcggc ctctgcataa ataaaaaaaa ttagtcagcc atggggcgga
120 gaatgggcgg aactgggcgg agttaggggc gggatgggcg gagttagggg
cgggactatg 180 gttgctgact aattgagatg catgctttgc atacttctgc
ctgctgggga gcctggttgc 240 tgactaattg agatgcatgc tttgcatact
tctgcctgct ggggagcctg gggactttcc 300 acaccctaac tgacacacat
tccacagctg cctcgcgcgt ttcggtgatg acggtgaaaa 360 cctctgacac
atgcagctcc cggagacggt cacagcttgt ctgtaagcgg atgccgggag 420
cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggcg cagccatgac
480 ccagtcacgt agcgatagcg gagtgtatac tggcttaact atgcggcatc
agagcagatt 540 gtactgagag tgcaccatat gcggtgtgaa ataccgcaca
gatgcgtaag gagaaaatac 600 cgcatcaggc gctcttccgc ttcctcgctc
actgactcgc tgcgctcggt cgttcggctg 660 cggcgagcgg tatcagctca
ctcaaaggcg gtaatacggt tatccacaga atcaggggat 720 aacgcaggaa
agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc 780
gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc
840 tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt
tccccctgga 900 agctccctcg tgcgctctcc tgttccgacc ctgccgctta
ccggatacct gtccgccttt 960 ctcccttcgg gaagcgtggc gctttctcat
agctcacgct gtaggtatct cagttcggtg 1020 taggtcgttc gctccaagct
gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc 1080 gccttatccg
gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg 1140
gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc
1200 ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat
ctgcgctctg 1260 ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt
gatccggcaa acaaaccacc 1320 gctggtagcg gtggtttttt tgtttgcaag
cagcagatta cgcgcagaaa aaaaggatct 1380 caagaagatc ctttgatctt
ttctacgggg tctgacgctc agtggaacga aaactcacgt 1440 taagggattt
tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa 1500
aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa
1560 tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc
catagttgcc 1620 tgactccccg tcgtgtagat aactacgata cgggagggct
taccatctgg ccccagtgct 1680 gcaatgatac cgcgagaccc acgctcaccg
gctccagatt tatcagcaat aaaccagcca 1740 gccggaaggg ccgagcgcag
aagtggtcct gcaactttat ccgcctccat ccagtctatt 1800 aattgttgcc
gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt 1860
gccattgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc
1920 ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa
agcggttagc 1980 tccttcggtc ctccgatcgt tgtcagaagt aagttggccg
cagtgttatc actcatggtt 2040 atggcagcac tgcataattc tcttactgtc
atgccatccg taagatgctt ttctgtgact 2100 ggtgagtact caaccaagtc
attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc 2160 ccggcgtcaa
cacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt 2220
ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg
2280 atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac
cagcgtttct 2340 gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg
gaataagggc gacacggaaa 2400 tgttgaatac tcatactctt cctttttcaa
tattattgaa gcatttatca gggttattgt 2460 ctcatgagcg gatacatatt
tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc 2520 acatttcccc
gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc 2580
tataaaaata ggcgtatcac gaggcccttt cgtcttcaag aattcagctt ggctgcagtg
2640 aataataaaa tgtgtgtttg tccgaaatac gcgttttgag atttctgtcg
ccgactaaat 2700 tcatgtcgcg cgatagtggt gtttatcgcc gatagagatg
gcgatattgg aaaaatcgat 2760 atttgaaaat atggcatatt gaaaatgtcg
ccgatgtgag tttctgtgta actgatatcg 2820 ccatttttcc aaaagtgatt
tttgggcata cgcgatatct ggcgatagcg cttatatcgt 2880 ttacggggga
tggcgataga cgactttggt gacttgggcg attctgtgtg tcgcaaatat 2940
cgcagtttcg atataggtga cagacgatat gaggctatat cgccgataga ggcgacatca
3000 agctggcaca tggccaatgc atatcgatct atacattgaa tcaatattgg
ccattagcca 3060 tattattcat tggttatata gcataaatca atattggcta
ttggccattg catacgttgt 3120 atccatatca taatatgtac atttatattg
gctcatgtcc aacattaccg ccatgttgac 3180 attgattatt gactagttat
taatagtaat caattacggg gtcattagtt catagcccat 3240 atatggagtt
ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg 3300
acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt
3360 tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca
gtacatcaag 3420 tgtatcatat gccaagtacg ccccctattg acgtcaatga
cggtaaatgg cccgcctggc 3480 attatgccca gtacatgacc ttatgggact
ttcctacttg gcagtacatc tacgtattag 3540 tcatcgctat taccatggtg
atgcggtttt ggcagtacat caatgggcgt ggatagcggt 3600 ttgactcacg
gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc 3660
accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg
3720 gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcgtttagtg
aaccgtcaga 3780 tcgcctggag acgccatcca cgctgttttg acctccatag
aagacaccgg gaccgatcca 3840 gcctccgcaa gcttgccgcc accatggact
ggacctggag ggtgttctgc ctgctggccg 3900 tggcccccgg cgcccacagc
gaggtgcagc tggtggagtc aggagccgaa gtgaaaaagc 3960 ctggggcttc
agtgaaggtg tcctgcaagg cctctggata cacattcact aattatatta 4020
tccactgggt gaagcaggag cctggtcagg gccttgaatg gattggatat tttaatcctt
4080 acaatcatgg tactaagtac aatgagaagt tcaaaggcag ggccacacta
actgcaaaca 4140 aatccatcag cacagcctac atggagctca gcagcctgcg
ctctgaggac actgcggtct 4200 actactgtgc aagatcagga ccctatgcct
ggtttgacac ctggggccaa gggaccacgg 4260 tcaccgtctc ctcaggtgag
ttctagaagg atcccaagct agctttctgg ggcaggccag 4320 gcctgacctt
ggctttgggg cagggagggg gctaaggtga ggcaggtggc gccagccagg 4380
tgcacaccca atgcccatga gcccagacac tggacgctga acctcgcgga cagttaagaa
4440 cccaggggcc tctgcgccct gggcccagct ctgtcccaca ccgcggtcac
atggcaccac 4500 ctctcttgca gcctccacca agggcccatc ggtcttcccc
ctggcaccct cctccaagag 4560 cacctctggg ggcacagcgg ccctgggctg
cctggtcaag gactacttcc ccgaaccggt 4620 gacggtgtcg tggaactcag
gcgccctgac cagcggcgtg cacaccttcc cggctgtcct 4680 acagtcctca
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg 4740
cacccagacc tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa
4800 agttggtgag aggccagcac agggagggag ggtgtctgct ggaagccagg
ctcagcgctc 4860
ctgcctggac gcatcccggc tatgcagccc cagtccaggg cagcaaggca ggccccgtct
4920 gcctcttcac ccggaggcct ctgcccgccc cactcatgct cagggagagg
gtcttctggc 4980 tttttcccca ggctctgggc aggcacaggc taggtgcccc
taacccaggc cctgcacaca 5040 aaggggcagg tgctgggctc agacctgcca
agagccatat ccgggaggac cctgcccctg 5100 acctaagccc accccaaagg
ccaaactctc cactccctca gctcggacac cttctctcct 5160 cccagattcc
agtaactccc aatcttctct ctgcagagcc caaatcttgt gacaaaactc 5220
acacatgccc accgtgccca ggtaagccag cccaggcctc gccctccagc tcaaggcggg
5280 acaggtgccc tagagtagcc tgcatccagg gacaggcccc agccgggtgc
tgacacgtcc 5340 acctccatct cttcctcagc acctgaactc ctggggggac
cgtcagtctt cctcttcccc 5400 ccaaaaccca aggacaccct catgatctcc
cggacccctg aggtcacatg cgtggtggtg 5460 gacgtgagcc acgaagaccc
tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 5520 cataatgcca
agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 5580
gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc
5640 aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg
tgggacccgt 5700 ggggtgcgag ggccacatgg acagaggccg gctcggccca
ccctctgccc tgagagtgac 5760 cgctgtacca acctctgtcc ctacagggca
gccccgagaa ccacaggtgt acaccctgcc 5820 cccatcccgg gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt 5880 ctatcccagc
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa 5940
gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
6000 ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct 6060 gcacaaccac tacacgcaga agagcctctc cctgtctccg
ggtaaatgag tgcgacggcc 6120 ggcaagcccc cgctccccgg gctctcgcgg
tcgcacgagg atgcttggca cgtaccccct 6180 gtacatactt cccgggcgcc
cagcatggaa ataaagcacc cagcgctgcc ctgggcccct 6240 gcgagactgt
gatggttctt tccacgggtc aggccgagtc tgaggcctga gtggcatgag 6300
atctgatatc atcgatgaat tcgagctcgg tacccgggga tcgatccaga catgataaga
6360 tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg
ctttatttgt 6420 gaaatttgtg atgctattgc tttatttgta accattataa
gctgcaataa acaagttaac 6480 aacaacaatt gcattcattt tatgtttcag
gttcaggggg aggtgtggga ggttttttaa 6540 agcaagtaaa acctctacaa
atgtggtatg gctgattatg atctctagtc aaggcactat 6600 acatcaaata
ttccttatta acccctttac aaattaaaaa gctaaaggta cacaattttt 6660
gagcatagtt attaatagca gacactctat gcctgtgtgg agtaagaaaa aacagtatgt
6720 tatgattata actgttatgc ctacttataa aggttacaga atatttttcc
ataattttct 6780 tgtatagcag tgcagctttt tcctttgtgg tgtaaatagc
aaagcaagca agagttctat 6840 tactaaacac agcatgactc aaaaaactta
gcaattctga aggaaagtcc ttggggtctt 6900 ctacctttct cttctttttt
ggaggagtag aatgttgaga gtcagcagta gcctcatcat 6960 cactagatgg
catttcttct gagcaaaaca ggttttcctc attaaaggca ttccaccact 7020
gctcccattc atcagttcca taggttggaa tctaaaatac acaaacaatt agaatcagta
7080 gtttaacaca ttatacactt aaaaatttta tatttacctt agagctttaa
atctctgtag 7140 gtagtttgtc caattatgtc acaccacaga agtaaggttc
cttcacaaag atccgggacc 7200 aaagcggcca tcgtgcctcc ccactcctgc
agttcggggg catggatgcg cggatagccg 7260 ctgctggttt cctggatgcc
gacggatttg cactgccggt agaactccgc gaggtcgtcc 7320 agcctcaggc
agcagctgaa ccaactcgcg aggggatcga gcccggggtg ggcgaagaac 7380
tccagcatga gatccccgcg ctggaggatc atccagccgg cgtcccggaa aacgattccg
7440 aagcccaacc tttcatagaa ggcggcggtg gaatcgaaat ctcgtgatgg
caggttgggc 7500 gtcgcttggt cggtcatttc gaaccccaga gtcccgctca
gaagaactcg tcaagaaggc 7560 gatagaaggc gatgcgctgc gaatcgggag
cggcgatacc gtaaagcacg aggaagcggt 7620 cagcccattc gccgccaagc
tcttcagcaa tatcacgggt agccaacgct atgtcctgat 7680 agcggtccgc
cacacccagc cggccacagt cgatgaatcc agaaaagcgg ccattttcca 7740
ccatgatatt cggcaagcag gcatcgccat gggtcacgac gagatcctcg ccgtcgggca
7800 tgcgcgcctt gagcctggcg aacagttcgg ctggcgcgag cccctgatgc
tcttcgtcca 7860 gatcatcctg atcgacaaga ccggcttcca tccgagtacg
tgctcgctcg atgcgatgtt 7920 tcgcttggtg gtcgaatggg caggtagccg
gatcaagcgt atgcagccgc cgcattgcat 7980 cagccatgat ggatactttc
tcggcaggag caaggtgaga tgacaggaga tcctgccccg 8040 gcacttcgcc
caatagcagc cagtcccttc ccgcttcagt gacaacgtcg agcacagctg 8100
cgcaaggaac gcccgtcgtg gccagccacg atagccgcgc tgcctcgtcc tgcagttcat
8160 tcagggcacc ggacaggtcg gtcttgacaa aaagaaccgg gcgcccctgc
gctgacagcc 8220 ggaacacggc ggcatcagag cagccgattg tctgttgtgc
ccagtcatag ccgaatagcc 8280 tctccaccca agcggccgga gaacctgcgt
gcaatccatc ttgttcaatc atgcgaaacg 8340 atcctcatcc tgtctcttga
tcagatcttg atcccctgcg ccatcagatc cttggcggca 8400 agaaagccat
ccagtttact ttgcagggct tcccaacctt accagagggc gccccagctg 8460
gcaattccgg ttcgcttgct gtccataaaa ccgcccagtc tagctatcgc catgtaagcc
8520 cactgcaagc tacctgcttt ctctttgcgc ttgcgttttc ccttgtccag
atagcccagt 8580 agctgacatt catccggggt cagcaccgtt tctgcggact
ggctttctac gtgttccgct 8640 tcctttagca gcccttgcgc cctgagtgct
tgcggcagcg tgaagct 8687 <210> SEQ ID NO 17 <211>
LENGTH: 9400 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: synthetic
expression vector <220> FEATURE: <223> OTHER
INFORMATION: Nucleotide sequence of the expression vector HCMV-K
HuAb-VL1 hum V1 (Complete DNA Sequence of a humanised light chain
expression vector comprising SEQ ID NO: 14 (humV1=VLh) from
3964-4284 <400> SEQUENCE: 17 ctagcttttt gcaaaagcct aggcctccaa
aaaagcctcc tcactacttc tggaatagct 60 cagaggccga ggcggcctcg
gcctctgcat aaataaaaaa aattagtcag ccatggggcg 120 gagaatgggc
ggaactgggc ggagttaggg gcgggatggg cggagttagg ggcgggacta 180
tggttgctga ctaattgaga tgcatgcttt gcatacttct gcctgctggg gagcctggtt
240 gctgactaat tgagatgcat gctttgcata cttctgcctg ctggggagcc
tggggacttt 300 ccacacccta actgacacac attccacagc tgcctcgcgc
gtttcggtga tgacggtgaa 360 aacctctgac acatgcagct cccggagacg
gtcacagctt gtctgtaagc ggatgccggg 420 agcagacaag cccgtcaggg
cgcgtcagcg ggtgttggcg ggtgtcgggg cgcagccatg 480 acccagtcac
gtagcgatag cggagtgtat actggcttaa ctatgcggca tcagagcaga 540
ttgtactgag agtgcaccat atgcggtgtg aaataccgca cagatgcgta aggagaaaat
600 accgcatcag gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg
gtcgttcggc 660 tgcggcgagc ggtatcagct cactcaaagg cggtaatacg
gttatccaca gaatcagggg 720 ataacgcagg aaagaacatg tgagcaaaag
gccagcaaaa ggccaggaac cgtaaaaagg 780 ccgcgttgct ggcgtttttc
cataggctcc gcccccctga cgagcatcac aaaaatcgac 840 gctcaagtca
gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg 900
gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct
960 ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat
ctcagttcgg 1020 tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc
ccccgttcag cccgaccgct 1080 gcgccttatc cggtaactat cgtcttgagt
ccaacccggt aagacacgac ttatcgccac 1140 tggcagcagc cactggtaac
aggattagca gagcgaggta tgtaggcggt gctacagagt 1200 tcttgaagtg
gtggcctaac tacggctaca ctagaaggac agtatttggt atctgcgctc 1260
tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca
1320 ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga
aaaaaaggat 1380 ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc
tcagtggaac gaaaactcac 1440 gttaagggat tttggtcatg agattatcaa
aaaggatctt cacctagatc cttttaaatt 1500 aaaaatgaag ttttaaatca
atctaaagta tatatgagta aacttggtct gacagttacc 1560 aatgcttaat
cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg 1620
cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg
1680 ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca
ataaaccagc 1740 cagccggaag ggccgagcgc agaagtggtc ctgcaacttt
atccgcctcc atccagtcta 1800 ttaattgttg ccgggaagct agagtaagta
gttcgccagt taatagtttg cgcaacgttg 1860 ttgccattgc tgcaggcatc
gtggtgtcac gctcgtcgtt tggtatggct tcattcagct 1920 ccggttccca
acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta 1980
gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg
2040 ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc
ttttctgtga 2100 ctggtgagta ctcaaccaag tcattctgag aatagtgtat
gcggcgaccg agttgctctt 2160 gcccggcgtc aacacgggat aataccgcgc
cacatagcag aactttaaaa gtgctcatca 2220 ttggaaaacg ttcttcgggg
cgaaaactct caaggatctt accgctgttg agatccagtt 2280 cgatgtaacc
cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt 2340
ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga
2400 aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat
cagggttatt 2460 gtctcatgag cggatacata tttgaatgta tttagaaaaa
taaacaaata ggggttccgc 2520 gcacatttcc ccgaaaagtg ccacctgacg
tctaagaaac cattattatc atgacattaa 2580 cctataaaaa taggcgtatc
acgaggccct ttcgtcttca agaattcagc ttggctgcag 2640 tgaataataa
aatgtgtgtt tgtccgaaat acgcgttttg agatttctgt cgccgactaa 2700
attcatgtcg cgcgatagtg gtgtttatcg ccgatagaga tggcgatatt ggaaaaatcg
2760 atatttgaaa atatggcata ttgaaaatgt cgccgatgtg agtttctgtg
taactgatat 2820 cgccattttt ccaaaagtga tttttgggca tacgcgatat
ctggcgatag cgcttatatc 2880 gtttacgggg gatggcgata gacgactttg
gtgacttggg cgattctgtg tgtcgcaaat 2940 atcgcagttt cgatataggt
gacagacgat atgaggctat atcgccgata gaggcgacat 3000 caagctggca
catggccaat gcatatcgat ctatacattg aatcaatatt ggccattagc 3060
catattattc attggttata tagcataaat caatattggc tattggccat tgcatacgtt
3120 gtatccatat cataatatgt acatttatat tggctcatgt ccaacattac
cgccatgttg 3180 acattgatta ttgactagtt attaatagta atcaattacg
gggtcattag ttcatagccc 3240
atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa
3300 cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc
caatagggac 3360 tttccattga cgtcaatggg tggagtattt acggtaaact
gcccacttgg cagtacatca 3420 agtgtatcat atgccaagta cgccccctat
tgacgtcaat gacggtaaat ggcccgcctg 3480 gcattatgcc cagtacatga
ccttatggga ctttcctact tggcagtaca tctacgtatt 3540 agtcatcgct
attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg 3600
gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg
3660 gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat
tgacgcaaat 3720 gggcggtagg cgtgtacggt gggaggtcta tataagcaga
gctcgtttag tgaaccgtca 3780 gatcgcctgg agacgccatc cacgctgttt
tgacctccat agaagacacc gggaccgatc 3840 cagcctccgc aagcttgata
tcgaattcct gcagcccggg ggatccgccc gcttgccgcc 3900 accatggaga
cccccgccca gctgctgttc ctgctgctgc tgtggctgcc cgacaccacc 3960
ggcgacattc tgctgaccca gtctccagcc accctgtctc tgagtccagg agaaagagcc
4020 actctctcct gcagggccag tcagaacatt ggcacaagca tacagtggta
tcaacaaaaa 4080 ccaggtcagg ctccaaggct tctcataagg tcttcttctg
agtctatctc tgggatccct 4140 tccaggttta gtggcagtgg atcagggaca
gattttactc ttaccatcag cagtctggag 4200 cctgaagatt ttgcagtgta
ttactgtcaa caaagtaata cctggccatt cacgttcggc 4260 caggggacca
agctggagat caaacgtgag tattctagaa agatcctaga attctaaact 4320
ctgagggggt cggatgacgt ggccattctt tgcctaaagc attgagttta ctgcaaggtc
4380 agaaaagcat gcaaagccct cagaatggct gcaaagagct ccaacaaaac
aatttagaac 4440 tttattaagg aataggggga agctaggaag aaactcaaaa
catcaagatt ttaaatacgc 4500 ttcttggtct ccttgctata attatctggg
ataagcatgc tgttttctgt ctgtccctaa 4560 catgccctgt gattatccgc
aaacaacaca cccaagggca gaactttgtt acttaaacac 4620 catcctgttt
gcttctttcc tcaggaactg tggctgcacc atctgtcttc atcttcccgc 4680
catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg aataacttct
4740 atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg
ggtaactccc 4800 aggagagtgt cacagagcag gacagcaagg acagcaccta
cagcctcagc agcaccctga 4860 cgctgagcaa agcagactac gagaaacaca
aagtctacgc ctgcgaagtc acccatcagg 4920 gcctgagctc gcccgtcaca
aagagcttca acaggggaga gtgttagagg gagaagtgcc 4980 cccacctgct
cctcagttcc agcctgaccc cctcccatcc tttggcctct gacccttttt 5040
ccacagggga cctaccccta ttgcggtcct ccagctcatc tttcacctca cccccctcct
5100 cctccttggc tttaattatg ctaatgttgg aggagaatga ataaataaag
tgaatctttg 5160 cacctgtggt ttctctcttt cctcatttaa taattattat
ctgttgttta ccaactactc 5220 aatttctctt ataagggact aaatatgtag
tcatcctaag gcgcataacc atttataaaa 5280 atcatccttc attctatttt
accctatcat cctctgcaag acagtcctcc ctcaaaccca 5340 caagccttct
gtcctcacag tcccctgggc catggtagga gagacttgct tccttgtttt 5400
cccctcctca gcaagccctc atagtccttt ttaagggtga caggtcttac agtcatatat
5460 cctttgattc aattccctga gaatcaacca aagcaaattt ttcaaaagaa
gaaacctgct 5520 ataaagagaa tcattcattg caacatgata taaaataaca
acacaataaa agcaattaaa 5580 taaacaaaca atagggaaat gtttaagttc
atcatggtac ttagacttaa tggaatgtca 5640 tgccttattt acatttttaa
acaggtactg agggactcct gtctgccaag ggccgtattg 5700 agtactttcc
acaacctaat ttaatccaca ctatactgtg agattaaaaa cattcattaa 5760
aatgttgcaa aggttctata aagctgagag acaaatatat tctataactc agcaatccca
5820 cttctagatg actgagtgtc cccacccacc aaaaaactat gcaagaatgt
tcaaagcagc 5880 tttatttaca aaagccaaaa attggaaata gcccgattgt
ccaacaatag aatgagttat 5940 taaactgtgg tatgtttata cattagaata
cccaatgagg agaattaaca agctacaact 6000 atacctactc acacagatga
atctcataaa aataatgtta cataagagaa actcaatgca 6060 aaagatatgt
tctgtatgtt ttcatccata taaagttcaa aaccaggtaa aaataaagtt 6120
agaaatttgg atggaaatta ctcttagctg ggggtgggcg agttagtgcc tgggagaaga
6180 caagaagggg cttctggggt cttggtaatg ttctgttcct cgtgtggggt
tgtgcagtta 6240 tgatctgtgc actgttctgt atacacatta tgcttcaaaa
taacttcaca taaagaacat 6300 cttataccca gttaatagat agaagaggaa
taagtaatag gtcaagacca cgcagctggt 6360 aagtgggggg gcctgggatc
aaatagctac ctgcctaatc ctgccctctt gagccctgaa 6420 tgagtctgcc
ttccagggct caaggtgctc aacaaaacaa caggcctgct attttcctgg 6480
catctgtgcc ctgtttggct agctaggagc acacatacat agaaattaaa tgaaacagac
6540 cttcagcaag gggacagagg acagaattaa ccttgcccag acactggaaa
cccatgtatg 6600 aacactcaca tgtttgggaa gggggaaggg cacatgtaaa
tgaggactct tcctcattct 6660 atggggcact ctggccctgc ccctctcagc
tactcatcca tccaacacac ctttctaagt 6720 acctctctct gcctacactc
tgaaggggtt caggagtaac taacacagca tcccttccct 6780 caaatgactg
acaatccctt tgtcctgctt tgtttttctt tccagtcagt actgggaaag 6840
tggggaagga cagtcatgga gaaactacat aaggaagcac cttgcccttc tgcctcttga
6900 gaatgttgat gagtatcaaa tctttcaaac tttggaggtt tgagtagggg
tgagactcag 6960 taatgtccct tccaatgaca tgaacttgct cactcatccc
tgggggccaa attgaacaat 7020 caaaggcagg cataatccag ctatgaattc
taggatcgat ccagacatga taagatacat 7080 tgatgagttt ggacaaacca
caactagaat gcagtgaaaa aaatgcttta tttgtgaaat 7140 ttgtgatgct
attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa 7200
caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa
7260 gtaaaacctc tacaaatgtg gtatggctga ttatgatctc tagtcaaggc
actatacatc 7320 aaatattcct tattaacccc tttacaaatt aaaaagctaa
aggtacacaa tttttgagca 7380 tagttattaa tagcagacac tctatgcctg
tgtggagtaa gaaaaaacag tatgttatga 7440 ttataactgt tatgcctact
tataaaggtt acagaatatt tttccataat tttcttgtat 7500 agcagtgcag
ctttttcctt tgtggtgtaa atagcaaagc aagcaagagt tctattacta 7560
aacacagcat gactcaaaaa acttagcaat tctgaaggaa agtccttggg gtcttctacc
7620 tttctcttct tttttggagg agtagaatgt tgagagtcag cagtagcctc
atcatcacta 7680 gatggcattt cttctgagca aaacaggttt tcctcattaa
aggcattcca ccactgctcc 7740 cattcatcag ttccataggt tggaatctaa
aatacacaaa caattagaat cagtagttta 7800 acacattata cacttaaaaa
ttttatattt accttagagc tttaaatctc tgtaggtagt 7860 ttgtccaatt
atgtcacacc acagaagtaa ggttccttca caaagatccg ggaccaaagc 7920
ggccatcgtg cctccccact cctgcagttc gggggcatgg atgcgcggat agccgctgct
7980 ggtttcctgg atgccgacgg atttgcactg ccggtagaac tccgcgaggt
cgtccagcct 8040 caggcagcag ctgaaccaac tcgcgagggg atcgagcccg
gggtgggcga agaactccag 8100 catgagatcc ccgcgctgga ggatcatcca
gccggcgtcc cggaaaacga ttccgaagcc 8160 caacctttca tagaaggcgg
cggtggaatc gaaatctcgt gatggcaggt tgggcgtcgc 8220 ttggtcggtc
atttcgaacc ccagagtccc gctcagaaga actcgtcaag aaggcgatag 8280
aaggcgatgc gctgcgaatc gggagcggcg ataccgtaaa gcacgaggaa gcggtcagcc
8340 cattcgccgc caagctcttc agcaatatca cgggtagcca acgctatgtc
ctgatagcgg 8400 tccgccacac ccagccggcc acagtcgatg aatccagaaa
agcggccatt ttccaccatg 8460 atattcggca agcaggcatc gccatgggtc
acgacgagat cctcgccgtc gggcatgcgc 8520 gccttgagcc tggcgaacag
ttcggctggc gcgagcccct gatgctcttc gtccagatca 8580 tcctgatcga
caagaccggc ttccatccga gtacgtgctc gctcgatgcg atgtttcgct 8640
tggtggtcga atgggcaggt agccggatca agcgtatgca gccgccgcat tgcatcagcc
8700 atgatggata ctttctcggc aggagcaagg tgagatgaca ggagatcctg
ccccggcact 8760 tcgcccaata gcagccagtc ccttcccgct tcagtgacaa
cgtcgagcac agctgcgcaa 8820 ggaacgcccg tcgtggccag ccacgatagc
cgcgctgcct cgtcctgcag ttcattcagg 8880 gcaccggaca ggtcggtctt
gacaaaaaga accgggcgcc cctgcgctga cagccggaac 8940 acggcggcat
cagagcagcc gattgtctgt tgtgcccagt catagccgaa tagcctctcc 9000
acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt caatcatgcg aaacgatcct
9060 catcctgtct cttgatcaga tcttgatccc ctgcgccatc agatccttgg
cggcaagaaa 9120 gccatccagt ttactttgca gggcttccca accttaccag
agggcgcccc agctggcaat 9180 tccggttcgc ttgctgtcca taaaaccgcc
cagtctagct atcgccatgt aagcccactg 9240 caagctacct gctttctctt
tgcgcttgcg ttttcccttg tccagatagc ccagtagctg 9300 acattcatcc
ggggtcagca ccgtttctgc ggactggctt tctacgtgtt ccgcttcctt 9360
tagcagccct tgcgccctga gtgcttgcgg cagcgtgaag 9400 <210> SEQ ID
NO 18 <211> LENGTH: 9362 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic expression vector <220> FEATURE:
<223> OTHER INFORMATION: Nucleotide sequence of the
expression vector HCMV-K HuAb-VL1 hum V2 (Complete DNA Sequence of
a humanised light chain expression vector comprising SEQ ID NO: 13
(humV2=VLm) from 3926-4246) <400> SEQUENCE: 18 ctagcttttt
gcaaaagcct aggcctccaa aaaagcctcc tcactacttc tggaatagct 60
cagaggccga ggcggcctcg gcctctgcat aaataaaaaa aattagtcag ccatggggcg
120 gagaatgggc ggaactgggc ggagttaggg gcgggatggg cggagttagg
ggcgggacta 180 tggttgctga ctaattgaga tgcatgcttt gcatacttct
gcctgctggg gagcctggtt 240 gctgactaat tgagatgcat gctttgcata
cttctgcctg ctggggagcc tggggacttt 300 ccacacccta actgacacac
attccacagc tgcctcgcgc gtttcggtga tgacggtgaa 360 aacctctgac
acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg 420
agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg cgcagccatg
480 acccagtcac gtagcgatag cggagtgtat actggcttaa ctatgcggca
tcagagcaga 540 ttgtactgag agtgcaccat atgcggtgtg aaataccgca
cagatgcgta aggagaaaat 600 accgcatcag gcgctcttcc gcttcctcgc
tcactgactc gctgcgctcg gtcgttcggc 660 tgcggcgagc ggtatcagct
cactcaaagg cggtaatacg gttatccaca gaatcagggg 720 ataacgcagg
aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg 780
ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac
840
gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg
900 gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac
ctgtccgcct 960 ttctcccttc gggaagcgtg gcgctttctc atagctcacg
ctgtaggtat ctcagttcgg 1020 tgtaggtcgt tcgctccaag ctgggctgtg
tgcacgaacc ccccgttcag cccgaccgct 1080 gcgccttatc cggtaactat
cgtcttgagt ccaacccggt aagacacgac ttatcgccac 1140 tggcagcagc
cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt 1200
tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt atctgcgctc
1260 tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc
aaacaaacca 1320 ccgctggtag cggtggtttt tttgtttgca agcagcagat
tacgcgcaga aaaaaaggat 1380 ctcaagaaga tcctttgatc ttttctacgg
ggtctgacgc tcagtggaac gaaaactcac 1440 gttaagggat tttggtcatg
agattatcaa aaaggatctt cacctagatc cttttaaatt 1500 aaaaatgaag
ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc 1560
aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg
1620 cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct
ggccccagtg 1680 ctgcaatgat accgcgagac ccacgctcac cggctccaga
tttatcagca ataaaccagc 1740 cagccggaag ggccgagcgc agaagtggtc
ctgcaacttt atccgcctcc atccagtcta 1800 ttaattgttg ccgggaagct
agagtaagta gttcgccagt taatagtttg cgcaacgttg 1860 ttgccattgc
tgcaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct 1920
ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta
1980 gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta
tcactcatgg 2040 ttatggcagc actgcataat tctcttactg tcatgccatc
cgtaagatgc ttttctgtga 2100 ctggtgagta ctcaaccaag tcattctgag
aatagtgtat gcggcgaccg agttgctctt 2160 gcccggcgtc aacacgggat
aataccgcgc cacatagcag aactttaaaa gtgctcatca 2220 ttggaaaacg
ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt 2280
cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt
2340 ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg
gcgacacgga 2400 aatgttgaat actcatactc ttcctttttc aatattattg
aagcatttat cagggttatt 2460 gtctcatgag cggatacata tttgaatgta
tttagaaaaa taaacaaata ggggttccgc 2520 gcacatttcc ccgaaaagtg
ccacctgacg tctaagaaac cattattatc atgacattaa 2580 cctataaaaa
taggcgtatc acgaggccct ttcgtcttca agaattcagc ttggctgcag 2640
tgaataataa aatgtgtgtt tgtccgaaat acgcgttttg agatttctgt cgccgactaa
2700 attcatgtcg cgcgatagtg gtgtttatcg ccgatagaga tggcgatatt
ggaaaaatcg 2760 atatttgaaa atatggcata ttgaaaatgt cgccgatgtg
agtttctgtg taactgatat 2820 cgccattttt ccaaaagtga tttttgggca
tacgcgatat ctggcgatag cgcttatatc 2880 gtttacgggg gatggcgata
gacgactttg gtgacttggg cgattctgtg tgtcgcaaat 2940 atcgcagttt
cgatataggt gacagacgat atgaggctat atcgccgata gaggcgacat 3000
caagctggca catggccaat gcatatcgat ctatacattg aatcaatatt ggccattagc
3060 catattattc attggttata tagcataaat caatattggc tattggccat
tgcatacgtt 3120 gtatccatat cataatatgt acatttatat tggctcatgt
ccaacattac cgccatgttg 3180 acattgatta ttgactagtt attaatagta
atcaattacg gggtcattag ttcatagccc 3240 atatatggag ttccgcgtta
cataacttac ggtaaatggc ccgcctggct gaccgcccaa 3300 cgacccccgc
ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac 3360
tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca
3420 agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat
ggcccgcctg 3480 gcattatgcc cagtacatga ccttatggga ctttcctact
tggcagtaca tctacgtatt 3540 agtcatcgct attaccatgg tgatgcggtt
ttggcagtac atcaatgggc gtggatagcg 3600 gtttgactca cggggatttc
caagtctcca ccccattgac gtcaatggga gtttgttttg 3660 gcaccaaaat
caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat 3720
gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca
3780 gatcgcctgg agacgccatc cacgctgttt tgacctccat agaagacacc
gggaccgatc 3840 cagcctccgc aagcttgccg ccaccatgga gacccccgcc
cagctgctgt tcctgctgct 3900 gctgtggctg cccgacacca ccggcgacat
tctgctgacc cagtctccag ccaccctgtc 3960 tctgagtcca ggagaaagag
ccactttctc ctgcagggcc agtcagaaca ttggcacaag 4020 catacagtgg
tatcaacaaa aaacaaatgg tgctccaagg cttctcataa ggtcttcttc 4080
tgagtctatc tctgggatcc cttccaggtt tagtggcagt ggatcaggga cagattttac
4140 tcttaccatc agcagtctgg agcctgaaga ttttgcagtg tattactgtc
aacaaagtaa 4200 tacctggcca ttcacgttcg gccaggggac caagctggag
atcaaacgtg agtattctag 4260 aaagatccta gaattctaaa ctctgagggg
gtcggatgac gtggccattc tttgcctaaa 4320 gcattgagtt tactgcaagg
tcagaaaagc atgcaaagcc ctcagaatgg ctgcaaagag 4380 ctccaacaaa
acaatttaga actttattaa ggaatagggg gaagctagga agaaactcaa 4440
aacatcaaga ttttaaatac gcttcttggt ctccttgcta taattatctg ggataagcat
4500 gctgttttct gtctgtccct aacatgccct gtgattatcc gcaaacaaca
cacccaaggg 4560 cagaactttg ttacttaaac accatcctgt ttgcttcttt
cctcaggaac tgtggctgca 4620 ccatctgtct tcatcttccc gccatctgat
gagcagttga aatctggaac tgcctctgtt 4680 gtgtgcctgc tgaataactt
ctatcccaga gaggccaaag tacagtggaa ggtggataac 4740 gccctccaat
cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc 4800
tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaagtctac
4860 gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt
caacagggga 4920 gagtgttaga gggagaagtg cccccacctg ctcctcagtt
ccagcctgac cccctcccat 4980 cctttggcct ctgacccttt ttccacaggg
gacctacccc tattgcggtc ctccagctca 5040 tctttcacct cacccccctc
ctcctccttg gctttaatta tgctaatgtt ggaggagaat 5100 gaataaataa
agtgaatctt tgcacctgtg gtttctctct ttcctcattt aataattatt 5160
atctgttgtt taccaactac tcaatttctc ttataaggga ctaaatatgt agtcatccta
5220 aggcgcataa ccatttataa aaatcatcct tcattctatt ttaccctatc
atcctctgca 5280 agacagtcct ccctcaaacc cacaagcctt ctgtcctcac
agtcccctgg gccatggtag 5340 gagagacttg cttccttgtt ttcccctcct
cagcaagccc tcatagtcct ttttaagggt 5400 gacaggtctt acagtcatat
atcctttgat tcaattccct gagaatcaac caaagcaaat 5460 ttttcaaaag
aagaaacctg ctataaagag aatcattcat tgcaacatga tataaaataa 5520
caacacaata aaagcaatta aataaacaaa caatagggaa atgtttaagt tcatcatggt
5580 acttagactt aatggaatgt catgccttat ttacattttt aaacaggtac
tgagggactc 5640 ctgtctgcca agggccgtat tgagtacttt ccacaaccta
atttaatcca cactatactg 5700 tgagattaaa aacattcatt aaaatgttgc
aaaggttcta taaagctgag agacaaatat 5760 attctataac tcagcaatcc
cacttctaga tgactgagtg tccccaccca ccaaaaaact 5820 atgcaagaat
gttcaaagca gctttattta caaaagccaa aaattggaaa tagcccgatt 5880
gtccaacaat agaatgagtt attaaactgt ggtatgttta tacattagaa tacccaatga
5940 ggagaattaa caagctacaa ctatacctac tcacacagat gaatctcata
aaaataatgt 6000 tacataagag aaactcaatg caaaagatat gttctgtatg
ttttcatcca tataaagttc 6060 aaaaccaggt aaaaataaag ttagaaattt
ggatggaaat tactcttagc tgggggtggg 6120 cgagttagtg cctgggagaa
gacaagaagg ggcttctggg gtcttggtaa tgttctgttc 6180 ctcgtgtggg
gttgtgcagt tatgatctgt gcactgttct gtatacacat tatgcttcaa 6240
aataacttca cataaagaac atcttatacc cagttaatag atagaagagg aataagtaat
6300 aggtcaagac cacgcagctg gtaagtgggg gggcctggga tcaaatagct
acctgcctaa 6360 tcctgccctc ttgagccctg aatgagtctg ccttccaggg
ctcaaggtgc tcaacaaaac 6420 aacaggcctg ctattttcct ggcatctgtg
ccctgtttgg ctagctagga gcacacatac 6480 atagaaatta aatgaaacag
accttcagca aggggacaga ggacagaatt aaccttgccc 6540 agacactgga
aacccatgta tgaacactca catgtttggg aagggggaag ggcacatgta 6600
aatgaggact cttcctcatt ctatggggca ctctggccct gcccctctca gctactcatc
6660 catccaacac acctttctaa gtacctctct ctgcctacac tctgaagggg
ttcaggagta 6720 actaacacag catcccttcc ctcaaatgac tgacaatccc
tttgtcctgc tttgtttttc 6780 tttccagtca gtactgggaa agtggggaag
gacagtcatg gagaaactac ataaggaagc 6840 accttgccct tctgcctctt
gagaatgttg atgagtatca aatctttcaa actttggagg 6900 tttgagtagg
ggtgagactc agtaatgtcc cttccaatga catgaacttg ctcactcatc 6960
cctgggggcc aaattgaaca atcaaaggca ggcataatcc agctatgaat tctaggatcg
7020 atccagacat gataagatac attgatgagt ttggacaaac cacaactaga
atgcagtgaa 7080 aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt
atttgtaacc attataagct 7140 gcaataaaca agttaacaac aacaattgca
ttcattttat gtttcaggtt cagggggagg 7200 tgtgggaggt tttttaaagc
aagtaaaacc tctacaaatg tggtatggct gattatgatc 7260 tctagtcaag
gcactataca tcaaatattc cttattaacc cctttacaaa ttaaaaagct 7320
aaaggtacac aatttttgag catagttatt aatagcagac actctatgcc tgtgtggagt
7380 aagaaaaaac agtatgttat gattataact gttatgccta cttataaagg
ttacagaata 7440 tttttccata attttcttgt atagcagtgc agctttttcc
tttgtggtgt aaatagcaaa 7500 gcaagcaaga gttctattac taaacacagc
atgactcaaa aaacttagca attctgaagg 7560 aaagtccttg gggtcttcta
cctttctctt cttttttgga ggagtagaat gttgagagtc 7620 agcagtagcc
tcatcatcac tagatggcat ttcttctgag caaaacaggt tttcctcatt 7680
aaaggcattc caccactgct cccattcatc agttccatag gttggaatct aaaatacaca
7740 aacaattaga atcagtagtt taacacatta tacacttaaa aattttatat
ttaccttaga 7800 gctttaaatc tctgtaggta gtttgtccaa ttatgtcaca
ccacagaagt aaggttcctt 7860 cacaaagatc cgggaccaaa gcggccatcg
tgcctcccca ctcctgcagt tcgggggcat 7920 ggatgcgcgg atagccgctg
ctggtttcct ggatgccgac ggatttgcac tgccggtaga 7980 actccgcgag
gtcgtccagc ctcaggcagc agctgaacca actcgcgagg ggatcgagcc 8040
cggggtgggc gaagaactcc agcatgagat ccccgcgctg gaggatcatc cagccggcgt
8100 cccggaaaac gattccgaag cccaaccttt catagaaggc ggcggtggaa
tcgaaatctc 8160 gtgatggcag gttgggcgtc gcttggtcgg tcatttcgaa
ccccagagtc ccgctcagaa 8220 gaactcgtca agaaggcgat agaaggcgat
gcgctgcgaa tcgggagcgg cgataccgta 8280 aagcacgagg aagcggtcag
cccattcgcc gccaagctct tcagcaatat cacgggtagc 8340 caacgctatg
tcctgatagc ggtccgccac acccagccgg ccacagtcga tgaatccaga 8400
aaagcggcca ttttccacca tgatattcgg caagcaggca tcgccatggg tcacgacgag
8460 atcctcgccg tcgggcatgc gcgccttgag cctggcgaac agttcggctg
gcgcgagccc 8520 ctgatgctct tcgtccagat catcctgatc gacaagaccg
gcttccatcc gagtacgtgc 8580 tcgctcgatg cgatgtttcg cttggtggtc
gaatgggcag gtagccggat caagcgtatg 8640 cagccgccgc attgcatcag
ccatgatgga tactttctcg gcaggagcaa ggtgagatga 8700 caggagatcc
tgccccggca cttcgcccaa tagcagccag tcccttcccg cttcagtgac 8760
aacgtcgagc acagctgcgc aaggaacgcc cgtcgtggcc agccacgata gccgcgctgc
8820 ctcgtcctgc agttcattca gggcaccgga caggtcggtc ttgacaaaaa
gaaccgggcg 8880 cccctgcgct gacagccgga acacggcggc atcagagcag
ccgattgtct gttgtgccca 8940 gtcatagccg aatagcctct ccacccaagc
ggccggagaa cctgcgtgca atccatcttg 9000 ttcaatcatg cgaaacgatc
ctcatcctgt ctcttgatca gatcttgatc ccctgcgcca 9060 tcagatcctt
ggcggcaaga aagccatcca gtttactttg cagggcttcc caaccttacc 9120
agagggcgcc ccagctggca attccggttc gcttgctgtc cataaaaccg cccagtctag
9180 ctatcgccat gtaagcccac tgcaagctac ctgctttctc tttgcgcttg
cgttttccct 9240 tgtccagata gcccagtagc tgacattcat ccggggtcag
caccgtttct gcggactggc 9300 tttctacgtg ttccgcttcc tttagcagcc
cttgcgccct gagtgcttgc ggcagcgtga 9360 ag 9362 <210> SEQ ID NO
19 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: chimeric murine-human construct <220> FEATURE:
<223> OTHER INFORMATION: hypervariable regions CDR1' in a
CD45RO/RB binding molecule of SEQ ID NO:1 <400> SEQUENCE: 19
Arg Ala Ser Gln Asn Ile Gly Thr Ser Ile Gln 1 5 10 <210> SEQ
ID NO 20 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: chimeric murine-human construct <220> FEATURE:
<223> OTHER INFORMATION: hypervariable region CDR2' in a
CD45RO/RB binding molecule of SEQ ID NO:1 <400> SEQUENCE: 20
Ser Ser Ser Glu Ser Ile Ser 1 5 <210> SEQ ID NO 21
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
chimeric murine-human construct <220> FEATURE: <223>
OTHER INFORMATION: hypervariable region CDR3' in a CD45RO/RB
binding molecule of SEQ ID NO:1 <400> SEQUENCE: 21 Gln Gln
Ser Asn Thr Trp Pro Phe Thr 1 5 <210> SEQ ID NO 22
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
chimeric murine-human construct <220> FEATURE: <223>
OTHER INFORMATION: hypervariable region CDR1 in a CD45RO/RB binding
molecule of SEQ ID NO:2 <400> SEQUENCE: 22 Asn Tyr Ile Ile
His 1 5 <210> SEQ ID NO 23 <211> LENGTH: 17 <212>
TYPE: PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric murine-human construct
<220> FEATURE: <223> OTHER INFORMATION: hypervariable
region CDR2 in a CD45RO/RB binding molecule of SEQ ID NO:2
<400> SEQUENCE: 23 Tyr Phe Asn Pro Tyr Asn His Gly Thr Lys
Tyr Asn Glu Lys Phe Lys 1 5 10 15 Gly <210> SEQ ID NO 24
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
chimeric murine-human construct <220> FEATURE: <223>
OTHER INFORMATION: hypervariable region CDR3 in a CD45RO/RB binding
molecule of SEQ ID NO:2 <400> SEQUENCE: 24 Ser Gly Pro Tyr
Ala Trp Phe Asp Thr 1 5 <210> SEQ ID NO 25 <211>
LENGTH: 33 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
murine-human construct <220> FEATURE: <223> OTHER
INFORMATION: polynucleotide sequence encoding the amino acid
sequence of CDR1 <400> SEQUENCE: 25 ggccagtcag aacattggca
caagcataca gtg 33 <210> SEQ ID NO 26 <211> LENGTH: 21
<212> TYPE: DNA <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: chimeric murine-human
construct <220> FEATURE: <223> OTHER INFORMATION:
polynucleotide sequence encoding the amino acid sequence of CDR2
<400> SEQUENCE: 26 ttcttctgag tctatctctg g 21 <210> SEQ
ID NO 27 <211> LENGTH: 27 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: chimeric murine-human construct <220> FEATURE:
<223> OTHER INFORMATION: polynucleotide sequence encoding the
amino acid sequence of CDR3 <400> SEQUENCE: 27 acaaagtaat
acctggccat tcacgtt 27 <210> SEQ ID NO 28 <211> LENGTH:
15 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
murine-human construct <220> FEATURE: <223> OTHER
INFORMATION: polynucleotide sequence encoding the amino acid
sequence of CDR1' <400> SEQUENCE: 28 ttatattatc cactg 15
<210> SEQ ID NO 29 <211> LENGTH: 51 <212> TYPE:
DNA <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric murine-human construct
<220> FEATURE: <223> OTHER INFORMATION: polynucleotide
sequence encoding the amino acid sequence of CDR2' <400>
SEQUENCE: 29 ttttaatcct tacaatcatg gtactaagta caatgagaag ttcaaaggca
g 51 <210> SEQ ID NO 30 <211> LENGTH: 27 <212>
TYPE: DNA <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: chimeric murine-human construct
<220> FEATURE: <223> OTHER INFORMATION: polynucleotide
sequence encoding the amino acid sequence of CDR3' <400>
SEQUENCE: 30 aggaccctat gcctggtttg acacctg 27 <210> SEQ ID NO
31 <211> LENGTH: 118 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: chimeric murine-human construct <220> FEATURE:
<223> OTHER INFORMATION: Part of amino acid sequence of
humanised heavy chain designated VHE-N73D <400> SEQUENCE: 31
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5
10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn
Tyr 20 25 30 Ile Ile His Trp Val Lys Gln Glu Pro Gly Gln Gly Leu
Glu Trp Ile 35 40 45 Gly Tyr Phe Asn Pro Tyr Asn His Gly Thr Lys
Tyr Asn Glu Lys Phe 50 55 60
Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65
70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp
Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210>
SEQ ID NO 32 <211> LENGTH: 118 <212> TYPE: PRT
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: chimeric murine-human construct <220>
FEATURE: <223> OTHER INFORMATION: Part of amino acid sequence
of humanised heavy chain designated VHQ-N73D <400> SEQUENCE:
32 Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Asn Tyr 20 25 30 Ile Ile His Trp Val Lys Gln Glu Pro Gly Gln Gly
Leu Glu Trp Ile 35 40 45 Gly Tyr Phe Asn Pro Tyr Asn His Gly Thr
Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Arg Ala Thr Leu Thr Ala
Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu
Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Gly
Pro Tyr Ala Trp Phe Asp Thr Trp Gly Gln Gly Thr 100 105 110 Thr Val
Thr Val Ser Ser 115 <210> SEQ ID NO 33 <211> LENGTH:
321 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
murine-human construct <220> FEATURE: <223> OTHER
INFORMATION: Nucleotide sequence encoding amino acid sequence SEQ
ID NO: 8 <400> SEQUENCE: 33 gacattctgc tgacccagtc tccagccacc
ctgtctctga gtccaggaga aagagccact 60 ctctcctgca gggccagtca
gaacattggc acaagcatac agtggtatca acaaaaacca 120 ggtcaggctc
caaggcttct cataaggtct tcttctgagt ctatctctgg gatcccttcc 180
aggtttagtg gcagtggatc agggacagat tttactctta ccatcagcag tctggagcct
240 gaagattttg cagtgtatta ctgtcaacaa agtaatacct ggccattcac
gttcggccag 300 gggaccaagc ttgaaatcaa a 321 <210> SEQ ID NO 34
<211> LENGTH: 354 <212> TYPE: DNA <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
chimeric murine-human construct <220> FEATURE: <223>
OTHER INFORMATION: Nucleotide sequence encoding amino acid sequence
SEQ ID NO: 31 <400> SEQUENCE: 34 gaggtgcagc tggtggagtc
aggagccgaa gtgaaaaagc ctggggcttc agtgaaggtg 60 tcctgcaagg
cctctggata cacattcact aattatatta tccactgggt gaagcaggag 120
cctggtcagg gccttgaatg gattggatat tttaatcctt acaatcatgg tactaagtac
180 aatgagaagt tcaaaggcag ggccacacta actgcagaca aatccatcag
cacagcctac 240 atggagctca gcagcctgcg ctctgaggac actgcggtct
actactgtgc aagatcagga 300 ccctatgcct ggtttgacac ctggggccaa
gggaccacgg tcaccgtctc ctca 354 <210> SEQ ID NO 35 <211>
LENGTH: 354 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: chimeric
murine-human construct <220> FEATURE: <223> OTHER
INFORMATION: Nucleotide sequence encoding amino acid sequence SEQ
ID NO: 32 <400> SEQUENCE: 35 caggtgcagc tggtggagtc aggagccgaa
gtgaaaaagc ctggggcttc agtgaaggtg 60 tcctgcaagg cctctggata
cacattcact aattatatta tccactgggt gaagcaggag 120 cctggtcagg
gccttgaatg gattggatat tttaatcctt acaatcatgg tactaagtac 180
aatgagaagt tcaaaggcag ggccacacta actgcagaca aatccatcag cacagcctac
240 atggagctca gcagcctgcg ctctgaggac actgcggtct actactgtgc
aagatcagga 300 ccctatgcct ggtttgacac ctggggccaa gggaccacgg
tcaccgtctc ctca 354 <210> SEQ ID NO 36 <211> LENGTH:
8096 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: synthetic
expression vector <220> FEATURE: <223> OTHER
INFORMATION: Nucleotide sequence of expression vector LCVL1Sp20
<400> SEQUENCE: 36 ctagagtcct agagaggtct ggtggagcct
gcaaaagtcc agctttcaaa ggaacacaga 60 agtatgtgta tggaatatta
gaagatgttg cttttactct taagttggtt cctaggaaaa 120 atagttaaat
actgtgactt taaaatgtga gagggttttc aagtactcat ttttttaaat 180
gtccaaaatt tttgtcaatc aatttgaggt cttgtttgtg tagaactgac attacttaaa
240 gtttaaccga ggaatgggag tgaggctctc tcatacccta ttcagaactg
acttttaaca 300 ataataaatt aagtttaaaa tatttttaaa tgaattgagc
aatgttgagt tggagtcaag 360 atggccgatc agaaccagaa cacctgcagc
agctggcagg aagcaggtca tgtggcaagg 420 ctatttgggg aagggaaaat
aaaaccacta ggtaaacttg tagctgtggt ttgaagaagt 480 ggttttgaaa
cactctgtcc agccccacca aaccgaaagt ccaggctgag caaaacacca 540
cctgggtaat ttgcatttct aaaataagtt gaggattcag ccgaaactgg agaggtcctc
600 ttttaactta ttgagttcaa ccttttaatt ttagcttgag tagttctagt
ttccccaaac 660 ttaagtttat cgacttctaa aatgtattta gaactcattt
tcaaaattag gttatgtaag 720 aaattgaagg actttagtgt ctttaatttc
taatatattt agaaaacttc ttaaaattac 780 tctattattc ttccctctga
ttattggtct ccattcaatt cttttccaat acccgaagca 840 tttacagtga
ctttgttcat gatctttttt agttgtttgt tttgccttac tattaagact 900
ttgacattct ggtcaaaacg gcttcacaaa tctttttcaa gaccactttc tgagtattca
960 ttttaggaga aatacttttt ttttaaatga atgcaattat ctaggacctg
caggcatgct 1020 gttttctgtc tgtccctaac atgccctgtg attatccgca
aacaacacac ccaagggcag 1080 aactttgtta cttaaacacc atcctgtttg
cttctttcct caggaactgt ggctgcacca 1140 tctgtcttca tcttcccgcc
atctgatgag cagttgaaat ctggaactgc ctctgttgtg 1200 tgcctgctga
ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc 1260
ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac
1320 agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa
agtctacgcc 1380 tgcgaagtca cccatcaggg cctgagctcg cccgtcacaa
agagcttcaa caggggagag 1440 tgttagaggg agaagtgccc ccacctgctc
ctcagttcca gcctgacccc ctcccatcct 1500 ttggcctctg accctttttc
cacaggggac ctacccctat tgcggtcctc cagctcatct 1560 ttcacctcac
ccccctcctc ctccttggct ttaattatgc taatgttgga ggagaatgaa 1620
taaataaagt gaatctttgc acctgtggtt tctctctttc ctcatttaat aattattatc
1680 tgttgtttta ccaactactc aatttctctt ataagggact aaatatgtag
tcatcctaag 1740 gcgggatatc gagatctgaa gctgatccag acatgataag
atacattgat gagtttggac 1800 aaaccacaac tagaatgcag tgaaaaaaat
gctttatttg tgaaatttgt gatgctattg 1860 ctttatttgt aaccattata
agctgcaata aacaagttaa caacaacaat tgcattcatt 1920 ttatgtttca
ggttcagggg gaggtgtggg aggtttttta aagcaagtaa aacctctaca 1980
aatgtggtat ggctgattat gatctctagt caaggcacta tacatcaaat attccttatt
2040 aaccccttta caaattaaaa agctaaaggt acacaatttt tgagcatagt
tattaatagc 2100 agacactcta tgcctgtgtg gagtaagaaa aaacagtatg
ttatgattat aactgttatg 2160 cctacttata aaggttacag aatatttttc
cataattttc ttgtatagca gtgcagcttt 2220 ttcctttgtg gtgtaaatag
caaagcaagc aagagttcta ttactaaaca cagcatgact 2280 caaaaaactt
agcaattctg aaggaaagtc cttggggtct tctacctttc tcttcttttt 2340
tggaggagta gaatgttgag agtcagcagt agcctcatca tcactagatg gcatttcttc
2400 tgagcaaaac aggttttcct cattaaaggc attccaccac tgctcccatt
catcagttcc 2460 ataggttgga atctaaaata cacaaacaat tagaatcagt
agtttaacac attatacact 2520 taaaaatttt atatttacct tagagcttta
aatctctgta ggtagtttgt ccaattatgt 2580 cacaccacag aagtaaggtt
ccttcacaaa gatccggacc aaagcggcca tcgtgcctcc 2640 ccactcctgc
agttcggggg catggatgcg cggatagccg ctgctggttt cctggatgcc 2700
gacggatttg cactgccggt agaactccgc gaggtcgtcc agcctcaggc agcagctgaa
2760 ccaactcgcg aggggatcga gcatccccca tggtcttata aaaatgcata
gctttaggag 2820 gggagcagag aacttgaaag catcttcctg ttagtctttc
ttctcgtaga cttcaaactt 2880 atacttgatg cctttttcct cctggacctc
agagaggacg cctgggtatt ctgggagaag 2940 tttatatttc cccaaatcaa
tttctgggaa aaacgtgtca ctttcaaatt cctgcatgat 3000 ccttgtcaca
aagagtctga ggtggcctgg ttgattcatg gcttcctggt aaacagaact 3060
gcctccgact atccaaacca tgtctacttt acttgccaat tccggttgtt caataagtct
3120 taaggcatca tccaaacttt tggcaagaaa atgagctcct cgtggtggtt
ctttgagttc 3180 tctactgaga actatattaa ttctgtcctt taaaggtcga
ttcttctcag gaatggagaa 3240 ccaggttttc ctacccataa tcaccagatt
ctgtttacct tccactgaag aggttgtggt 3300 cattctttgg aagtacttga
actcgttcct gagcggaggc cagggtcggt ctccgttctt 3360 gccaatcccc
atattttggg acacggcgac gatgcagttc aatggtcgaa ccatgatggc 3420
agcggggata aaatcctacc agccttcacg ctaggattgc cgtcaagttt gggggtaccg
3480
agctcgaatt agctttttgc aaaagcctag gcctccaaaa aagcctcctc actacttctg
3540 gaatagctca gagggccgag gcggcctcgg cctctgcata aataaaaaaa
attagtcagc 3600 catggggcgg agaatgggcg gaactgggcg gagttagggg
cgggatgggc ggagttaggg 3660 gcgggactat ggttgctgac taattgagat
gcatgctttg catacttctg cctgctgggg 3720 agcctgggga ctttccacac
ctggttgctg actaattgag atgcatgctt tgcatacttc 3780 tgcctgctgg
ggagcctggg gactttccac accctaactg acacacattc cacagctgcc 3840
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca
3900 cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg
tcagcgggtg 3960 ttggcgggtg tcggggcgca gccatgaccc agtcacgtag
cgatagcgga gtgtatactg 4020 gcttaactat gcggcatcag agcagattgt
actgagagtg caccatatgc ggccgcatat 4080 gcggtgtgaa ataccgcaca
gatgcgtaag gagaaaatac cgcatcaggc gctcttccgc 4140 ttcctcgctc
actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca 4200
ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg
4260 agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg
cgtttttcca 4320 taggctccgc ccccctgacg agcatcacaa aaatcgacgc
tcaagtcaga ggtggcgaaa 4380 cccgacagga ctataaagat accaggcgtt
tccccctgga agctccctcg tgcgctctcc 4440 tgttccgacc ctgccgctta
ccggatacct gtccgccttt ctcccttcgg gaagcgtggc 4500 gctttctcat
agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct 4560
gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg
4620 tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca
ctggtaacag 4680 gattagcaga gcgaggtatg taggcggtgc tacagagttc
ttgaagtggt ggcctaacta 4740 cggctacact agaaggacag tatttggtat
ctgcgctctg ctgaagccag ttaccttcgg 4800 aaaaagagtt ggtagctctt
gatccggcaa acaaaccacc gctggtagcg gtggtttttt 4860 tgtttgcaag
cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt 4920
ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag
4980 attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt
ttaaatcaat 5040 ctaaagtata tatgagtaaa cttggtctga cagttaccaa
tgcttaatca gtgaggcacc 5100 tatctcagcg atctgtctat ttcgttcatc
catagttgcc tgactccccg tcgtgtagat 5160 aactacgata cgggagggct
taccatctgg ccccagtgct gcaatgatac cgcgagaccc 5220 acgctcaccg
gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag 5280
aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag
5340 agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgctg
caggcatcgt 5400 ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc
ggttcccaac gatcaaggcg 5460 agttacatga tcccccatgt tgtgcaaaaa
agcggttagc tccttcggtc ctccgatcgt 5520 tgtcagaagt aagttggccg
cagtgttatc actcatggtt atggcagcac tgcataattc 5580 tcttactgtc
atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc 5640
attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa cacgggataa
5700 taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt
cttcggggcg 5760 aaaactctca aggatcttac cgctgttgag atccagttcg
atgtaaccca ctcgtgcacc 5820 caactgatct tcagcatctt ttactttcac
cagcgtttct gggtgagcaa aaacaggaag 5880 gcaaaatgcc gcaaaaaagg
gaataagggc gacacggaaa tgttgaatac tcatactctt 5940 cctttttcaa
tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt 6000
tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc
6060 acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata
ggcgtatcac 6120 gaggcccttt cgtcttcaag aattcagctg ctcgaggaag
agctcaaacc catgctactc 6180 tctggcttga tggaagcaac gctttcatag
ctgagctgtc ataaataata aagagatttt 6240 tttattaata ttgaaaagat
gggttattta tgtaagactc tgtcttcatt ttaaaaacca 6300 caccttccag
tagtattctg ttactgttct ggcaatcact gtgatcaaga agctacacgg 6360
tgagttgtgc ttctcagtcc taagggatac atctacaaga ggctcccata ctcgaagctc
6420 aggaaacatt gtagaaaagg aggcaaaaga ctgacagagc cagaggacca
agaaatttgt 6480 tgtgaggttg tgtctcctac taacaatata agcaatatct
ataaattgtt gatatcatgg 6540 ctactaaaat gtgagttgaa cgaggaggac
acaaatgaac atgacaatca gaatgaggcc 6600 tctcacctgc aaaaaacact
atagagaagc agataaagct gtcagcagaa gaggcgcacc 6660 tccttataga
agaagcctac caggtttgat atatcagcct tgaaaaccta catagtattt 6720
acattatatc gagtctatga gacatattta gtaatgcata tgtatgtgtg tgtgtgcatg
6780 tatgtgtgta aatacatatg ttcatagaaa aatgtgtaaa aagagatcat
gaatttaaga 6840 gagaactggg acaatttttt tcagggagtt gtaatcagga
aagttaaggg aaaaatgttg 6900 taattaaaat tcaggctcag aaacaaacaa
aggaaaagaa aaaaaaacaa caacaacaac 6960 aaaaaaacaa aacaaaggag
aagctgtatg gccacaatag catctacagc taactgtgaa 7020 aggataatgg
aacaagttat gtactgccta gagcagtatg atgcctaaat catctcgaca 7080
tggaggaaaa tagaacaaag acactctaca tagactatga tagaaatcaa aataaggtgt
7140 aagacataga acattagttt tgtttgttgt tcaaagagac tcacattccc
acaaaaaaat 7200 ctgtgggatt ttacaggtct gcaataagct gctgacctga
tgatttctgc agctgtgcct 7260 accctttgct gatttgcatg tacccaaagc
atagcttact gacatgagga tttcttcata 7320 gtcaggtcac accctttgct
ggagtcagaa tcacactgat cacacacagt catgagtgtg 7380 ctcactcagg
tcctggcgtt gctgctgctg tggcttacag gtaatgaaga cagcactaga 7440
attttattga gcttcctgta cactgtgctg cttgtctctg tgaaaattct cttgtgaatt
7500 aatcatgtgg ggatctgttt tcaatttttc aattgtaggt acgcgttgtg
acattctgct 7560 gacccagtct ccagccaccc tgtctctgag tccaggagaa
agagccactc tctcctgcag 7620 ggccagtcag aacattggca caagcataca
gtggtatcaa caaaaaccag gtcaggctcc 7680 aaggcttctc ataaggtctt
cttctgagtc tatctctggg atcccttcca ggtttagtgg 7740 cagtggatca
gggacagatt ttactcttac catcagcagt ctggagcctg aagattttgc 7800
agtgtattac tgtcaacaaa gtaatacctg gccattcacg ttcggccagg ggaccaagct
7860 tgaaatcaaa cgtaagtaga atccaaagtc tctttcttcc gttgtctatg
tctgtggctt 7920 ctatgtctaa aaatgatgta taaaatctta ctctgaaacc
agattctggc actctccaag 7980 gcaaagatac agagtaactc cgtaagcaaa
gctgggaata ggctagacat gttctctgga 8040 gaatgaatgc cagtgtaata
attaacacaa gtgatagttt cagaaatgct ctagtt 8096 <210> SEQ ID NO
37 <211> LENGTH: 11563 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic expression vector <220> FEATURE:
<223> OTHER INFORMATION: Nucleotide sequence of the
expression vector HCVHEN73DSp20 <400> SEQUENCE: 37 ctagagaggt
ctggtggagc ctgcaaaagt ccagctttca aaggaacaca gaagtatgtg 60
tatggaatat tagaagatgt tgcttttact cttaagttgg ttcctaggaa aaatagttaa
120 atactgtgac tttaaaatgt gagagggttt tcaagtactc atttttttaa
atgtccaaaa 180 tttttgtcaa tcaatttgag gtcttgtttg tgtagaactg
acattactta aagtttaacc 240 gaggaatggg agtgaggctc tctcataccc
tattcagaac tgacttttaa caataataaa 300 ttaagtttaa aatattttta
aatgaattga gcaatgttga gttggagtca agatggccga 360 tcagaaccag
aacacctgca gcagctggca ggaagcaggt catgtggcaa ggctatttgg 420
ggaagggaaa ataaaaccac taggtaaact tgtagctgtg gtttgaagaa gtggttttga
480 aacactctgt ccagccccac caaaccgaaa gtccaggctg agcaaaacac
cacctgggta 540 atttgcattt ctaaaataag ttgaggattc agccgaaact
ggagaggtcc tcttttaact 600 tattgagttc aaccttttaa ttttagcttg
agtagttcta gtttccccaa acttaagttt 660 atcgacttct aaaatgtatt
taagctttct ggggcaggcc aggcctgacc ttggctttgg 720 ggcagggagg
gggctaaggt gaggcaggtg gcgccagcca ggtgcacacc caatgcccat 780
gagcccagac actggacgct gaacctcgcg gacagttaag aacccagggg cctctgcgcc
840 ctgggcccag ctctgtccca caccgcggtc acatggcacc acctctcttg
cagcctccac 900 caagggccca tcggtcttcc ccctggcacc ctcctccaag
agcacctctg ggggcacagc 960 ggccctgggc tgcctggtca aggactactt
ccccgaaccg gtgacggtgt cgtggaactc 1020 aggcgccctg accagcggcg
tgcacacctt cccggctgtc ctacagtcct caggactcta 1080 ctccctcagc
agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg 1140
caacgtgaat cacaagccca gcaacaccaa ggtggacaag agagttggtg agaggccagc
1200 acagggaggg agggtgtctg ctggaagcca ggctcagcgc tcctgcctgg
acgcatcccg 1260 gctatgcagt cccagtccag ggcagcaagg caggccccgt
ctgcctcttc acccggaggc 1320 ctctgcccgc cccactcatg ctcagggaga
gggtcttctg gctttttccc caggctctgg 1380 gcaggcacag gctaggtgcc
cctaacccag gccctgcaca caaaggggca ggtgctgggc 1440 tcagacctgc
caagagccat atccgggagg accctgcccc tgacctaagc ccaccccaaa 1500
ggccaaactc tccactccct cagctcggac accttctctc ctcccagatt ccagtaactc
1560 ccaatcttct ctctgcagag cccaaatctt gtgacaaaac tcacacatgc
ccaccgtgcc 1620 caggtaagcc agcccaggcc tcgccctcca gctcaaggcg
ggacaggtgc cctagagtag 1680 cctgcatcca gggacaggcc ccagccgggt
gctgacacgt ccacctccat ctcttcctca 1740 gcacctgaac tcctgggggg
accgtcagtc ttcctcttcc ccccaaaacc caaggacacc 1800 ctcatgatct
cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 1860
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag
1920 ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac
cgtcctgcac 1980 caggactggc tgaatggcaa ggagtacaag tgcaaggtct
ccaacaaagc cctcccagcc 2040 cccatcgaga aaaccatctc caaagccaaa
ggtgggaccc gtggggtgcg agggccacat 2100 ggacagaggc cggctcggcc
caccctctgc cctgagagtg accgctgtac caacctctgt 2160 ccctacaggg
cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat 2220
gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc
2280 cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc
ctcccgtgct 2340 ggactccgac ggctccttct tcctctatag caagctcacc
gtggacaaga gcaggtggca 2400 gcaggggaac gtcttctcat gctccgtgat
gcatgaggct ctgcacaacc actacacgca 2460 gaagagcctc tccctgtccc
cgggtaaatg agtgcgacgg ccggcaagcc cccgctcccc 2520
gggctctcgc ggtcgcacga ggatgcttgg cacgtacccc gtctacatac ttcccaggca
2580 cccagcatgg aaataaagca cccaccactg ccctgggccc ctgcgagact
gtgatggttc 2640 tttccacggg tcaggccgag tctgaggcct gagtggcatg
agggaggcag agcgggtccc 2700 actgtcccca cactggccca ggctgtgcag
gtgtgcctgg gccgcctagg gtggggctca 2760 gccaggggct gccctcggca
gggtggggga tttgccagcg tggccctccc tccagcagca 2820 gctgccctgg
gctgggccac gagaagccct aggagcccct ggggacagac acacagcccc 2880
tgcctctgta ggagactgtc ctgtcctgtg agcgccctgt cctccgaccc cgatgcccac
2940 tcgggggcat gcctagtcca tgcgcgtagg gacaggccct ccctcaccca
tctaccccca 3000 cggcactaac ccctggcagc cctgcccagc ctcgcacccg
catggggaca caaccgactc 3060 cggggacatg cactctcggg ccctgtggag
ggactggtgc agatgcccac acacacactc 3120 agcccagacc cgttcaacaa
accccgcact gaggttggtc gagcgggagt gcggccagag 3180 cctgcctcgg
ccgtcaggga ggactcccgg gctcactcga aggaggtgcc accatttcag 3240
ctttggtagc ttttcttctt cttttaaatt ttctaaagct cattaattgt ctttgatgtt
3300 tcttttgtga tgacaataaa atatcctttt taagtcttgt acttcgtgat
gggagccgcc 3360 ttcctgtgtc cacgcgcctc ctgcccccgg tgggaagcac
ggtcaggagg aggctggtcc 3420 agctgcacct cgggggctcc ctgcactcgc
cccccgcctc ctgcagccac acgcattgcc 3480 cgagcgaccc tccctggccc
ctgtcactac atggacccct ggggcttctc ctcttttcta 3540 catggatgca
gtttctcctc ctgctgggca cggtgctgcc tgccctggtc actctgcggg 3600
ggacagggcc tccagggaaa gctgggtcga ggctgggagc tggctcaggc tggccaggca
3660 gagccacagg gagggccttc cagaaccaac catggtccga agcgagaggt
gggtgtcaga 3720 tccagacatg ataagataca ttgatgagtt tggacaaacc
acaactagaa tgcagtgaaa 3780 aaaatgcttt atttgtgaaa tttgtgatgc
tattgcttta tttgtaacca ttataagctg 3840 caataaacaa gttaacaaca
acaattgcat tcattttatg tttcaggttc agggggaggt 3900 gtgggaggtt
ttttaaagca agtaaaacct ctacaaatgt ggtatggctg attatgatct 3960
ctagtcaagg cactatacat caaatattcc ttattaaccc ctttacaaat taaaaagcta
4020 aaggtacaca atttttgagc atagttatta atagcagaca ctctatgcct
gtgtggagta 4080 agaaaaaaca gtatgttatg attataactg ttatgcctac
ttataaaggt tacagaatat 4140 ttttccataa ttttcttgta tagcagtgca
gctttttcct ttgtggtgta aatagcaaag 4200 caagcaagag ttctattact
aaacacagca tgactcaaaa aacttagcaa ttctgaagga 4260 aagtccttgg
ggtcttctac ctttctcttc ttttttggag gagtagaatg ttgagagtca 4320
gcagtagcct catcatcact agatggcatt tcttctgagc aaaacaggtt ttcctcatta
4380 aaggcattcc accactgctc ccattcatca gttccatagg ttggaatcta
aaatacacaa 4440 acaattagaa tcagtagttt aacacattat acacttaaaa
attttatatt taccttagag 4500 ctttaaatct ctgtaggtag tttgtccaat
tatgtcacac cacagaagta aggttccttc 4560 acaaagatcc ggaccaaagc
ggccatcgtg cctccccact cctgcagttc gggggcatgg 4620 atgcgcggat
agccgctgct ggtttcctgg atgccgacgg atttgcactg ccggtagaac 4680
tccgcgaggt cgtccagcct caggcagcag ctgaaccaac tcgcgagggg atcgagcccg
4740 gggtgggcga agaactccag catgagatcc ccgcgctgga ggatcatcca
gccggcgtcc 4800 cggaaaacga ttccgaagcc caacctttca tagaaggcgg
cggtggaatc gaaatctcgt 4860 gatggcaggt tgggcgtcgc ttggtcggtc
atttcgaacc ccagagtccc gctcagaaga 4920 actcgtcaag aaggcgatag
aaggcgatgc gctgcgaatc gggagcggcg ataccgtaaa 4980 gcacgaggaa
gcggtcagcc cattcgccgc caagctcttc agcaatatca cgggtagcca 5040
acgctatgtc ctgatagcgg tccgccacac ccagccggcc acagtcgatg aatccagaaa
5100 agcggccatt ttccaccatg atattcggca agcaggcatc gccatgggtc
acgacgagat 5160 cctcgccgtc gggcatgcgc gccttgagcc tggcgaacag
ttcggctggc gcgagcccct 5220 gatgctcttc gtccagatca tcctgatcga
caagaccggc ttccatccga gtacgtgctc 5280 gctcgatgcg atgtttcgct
tggtggtcga atgggcaggt agccggatca agcgtatgca 5340 gccgccgcat
tgcatcagcc atgatggata ctttctcggc aggagcaagg tgagatgaca 5400
ggagatcctg ccccggcact tcgcccaata gcagccagtc ccttcccgct tcagtgacaa
5460 cgtcgagcac agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc
cgcgctgcct 5520 cgtcctgcag ttcattcagg gcaccggaca ggtcggtctt
gacaaaaaga accgggcgcc 5580 cctgcgctga cagccggaac acggcggcat
cagagcagcc gattgtctgt tgtgcccagt 5640 catagccgaa tagcctctcc
acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt 5700 caatcatgcg
aaacgatcct catcctgtct cttgatcaga tcttgatccc ctgcgccatc 5760
agatccttgg cggcaagaaa gccatccagt ttactttgca gggcttccca accttaccag
5820 agggcgcccc agctggcaat tccggttcgc ttgctgtcca taaaaccgcc
cagtctagct 5880 atcgccatgt aagcccactg caagctacct gctttctctt
tgcgcttgcg ttttcccttg 5940 tccagatagc ccagtagctg acattcatcc
ggggtcagca ccgtttctgc ggactggctt 6000 tctacgtgtt ccgcttcctt
tagcagccct tgcgccctga gtgcttgcgg cagcgtgaag 6060 ctttttgcaa
aagcctaggc ctccaaaaaa gcctcctcac tacttctgga atagctcaga 6120
ggccgaggcg gcctcggcct ctgcataaat aaaaaaaatt agtcagccat ggggcggaga
6180 atgggcggaa ctgggcggag ttaggggcgg gatgggcgga gttaggggcg
ggactatggt 6240 tgctgactaa ttgagatgca tgctttgcat acttctgcct
gctggggagc ctggggactt 6300 tccacacctg gttgctgact aattgagatg
catgctttgc atacttctgc ctgctgggga 6360 gcctggggac tttccacacc
ctaactgaca cacattccac agctgcctcg cgcgtttcgg 6420 tgatgacggt
gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta 6480
agcggatgcc gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg
6540 gggcgcagcc atgacccagt cacgtagcga tagcggagtg tatactggct
taactatgcg 6600 gcatcagagc agattgtact gagagtgcac catatgcggt
gtgaaatacc gcacagatgc 6660 gtaaggagaa aataccgcat caggcgctct
tccgcttcct cgctcactga ctcgctgcgc 6720 tcggtcgttc ggctgcggcg
agcggtatca gctcactcaa aggcggtaat acggttatcc 6780 acagaatcag
gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg 6840
aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat
6900 cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata
aagataccag 6960 gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc
cgaccctgcc gcttaccgga 7020 tacctgtccg cctttctccc ttcgggaagc
gtggcgcttt ctcatagctc acgctgtagg 7080 tatctcagtt cggtgtaggt
cgttcgctcc aagctgggct gtgtgcacga accccccgtt 7140 cagcccgacc
gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac 7200
gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc
7260 ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag
gacagtattt 7320 ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa
gagttggtag ctcttgatcc 7380 ggcaaacaaa ccaccgctgg tagcggtggt
ttttttgttt gcaagcagca gattacgcgc 7440 agaaaaaaag gatctcaaga
agatcctttg atcttttcta cggggtctga cgctcagtgg 7500 aacgaaaact
cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag 7560
atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg
7620 tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg
tctatttcgt 7680 tcatccatag ttgcctgact ccccgtcgtg tagataacta
cgatacggga gggcttacca 7740 tctggcccca gtgctgcaat gataccgcga
gacccacgct caccggctcc agatttatca 7800 gcaataaacc agccagccgg
aagggccgag cgcagaagtg gtcctgcaac tttatccgcc 7860 tccatccagt
ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt 7920
ttgcgcaacg ttgttgccat tgctgcaggc atcgtggtgt cacgctcgtc gtttggtatg
7980 gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc
catgttgtgc 8040 aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca
gaagtaagtt ggccgcagtg 8100 ttatcactca tggttatggc agcactgcat
aattctctta ctgtcatgcc atccgtaaga 8160 tgcttttctg tgactggtga
gtactcaacc aagtcattct gagaatagtg tatgcggcga 8220 ccgagttgct
cttgcccggc gtcaacacgg gataataccg cgccacatag cagaacttta 8280
aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg
8340 ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc
atcttttact 8400 ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa
atgccgcaaa aaagggaata 8460 agggcgacac ggaaatgttg aatactcata
ctcttccttt ttcaatatta ttgaagcatt 8520 tatcagggtt attgtctcat
gagcggatac atatttgaat gtatttagaa aaataaacaa 8580 ataggggttc
cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt 8640
atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct tcaagaattc
8700 gagctcggta cccatcagcc aaaaagcatg cctgccacac aacatcaatt
tctggaaaac 8760 gctacactta attatttcta gtagaacagc tctttggttt
gccaaaaaga atcacctata 8820 gtggcatcta agcacaaaaa ggagaaaaaa
atcacaaaga aatgattgag aggcataata 8880 aaaattatca aaaaattatg
agttttacga tttcatcttt ttccaagttg aaatcatagg 8940 gtggctttaa
cacagtgaca aggaatgtgc atgctgccat tatggtgctc tgcctaaaat 9000
ggttggagcc ttgtcatgct acagagaaac tgtcatacag cagggggtgc caaatttcca
9060 tattttttta tatcattgag caggtgcaca gaagaccaga aagcactttc
tatcaggctg 9120 gccttcctct tcctttccag tatgaagcaa aaactgccaa
tgaaactagc aattgttaaa 9180 ttcctttttc aaacagtatt tgtgctatca
gaacatagtg cattcaaaag tctagcctga 9240 gagaacaacc cagttttatt
cattcctcct actacctctc tcattcccac tgtttgtgtt 9300 ctccctccca
ttttaattgt ctatctagtc caaactaagc acacgatcca gtccacatta 9360
aacaacatgt tttcacttta agtcaaatac aagacacctt taatatcagc ccttgttcat
9420 aatcgtgctt ctagtgactt aatgtacatg tcacactgta ctgttgggtt
ttgtgtctca 9480 tcatgaacaa tgttgtgaag gtattaagtg gagagtaagc
agaattagat tcctctaatg 9540 atgcacaccc acactaagag cagaaataat
attaaaaata gaaaaaaaag ttttacatga 9600 gatttcaaat acccaggtat
gagctgcagt ttcttcaagt taaagcatcg aggttgtcag 9660 ttacactatt
acaggaaaca tatgcagagt ttttatttta gtatattagt tttcacatat 9720
gtggaattac tattaaacta ttctttcttt tcaaatgctt accattgtaa atgagtttgt
9780 gactttgtgt aggtgagtgc acatgactct ggatgcctaa gaggactgaa
gaagttggag 9840 ttataggtag ttttattcta cttgactgtt cagtgctaaa
aatacaactg aggtccttta 9900 aactgctgtt catgaacttc ttaattgata
tatctcatga gatctctaaa ctatttttat 9960 tatgacacgt ttcaccattt
tcactgtaac gatttttatg ttttatatta atgtaactat 10020
atgacacttc ccaaaatccc catattcaca attgaactgt ttcaaagttt taccttgact
10080 tatgggaaat gaaaacccac attttataat tttaaaatga aatgtttatt
ttatatttct 10140 gcaaatttca caaggaaaga ttagtcactg gtgtgtgaga
gcagaggagc ataagagttc 10200 aggaatagaa tccattatga ttctggaggc
aaggaagaac tgatgccaag gtttcagtat 10260 aagagcagta tccactggaa
aggataaagt cactacatct gagcacagag caggacatct 10320 acataatgag
tggtcactaa tgggccactg ttacactgtt atatgtataa ggctcaagaa 10380
tgagcactga ggctgtaagg tgtatgggtg aggacatcag gatgtaaacc cagctcaggt
10440 agaggactca gaggacagca cagtcagcat gaactaataa acatcagata
agataaggca 10500 caagctcagc tatatagggt aagggatctt tgtaaatctg
attgtgcatc cagtctagtt 10560 caatgtgact taggaagccc agtcatatgc
aaatctagag aagactttag agtagaaatc 10620 tgaggctcac ctcacatacc
agcaagcgag tgaccagtta gtcttaaggc accacttctt 10680 agacatcatg
gcttgggtgt ggaccttgcc attcctgatg gcagctgccc aaagtaagac 10740
atcagaaaaa agagttccaa ggggaattga agcagttcca tgaatactca ccttcctgtg
10800 ttcttttcac aggtgtccag gcagaggtgc agctggtgga gtcaggagcc
gaagtgaaaa 10860 agcctggggc ttcagtgaag gtgtcctgca aggcctctgg
atacacattc actaattata 10920 ttatccactg ggtgaagcag gagcctggtc
agggccttga atggattgga tattttaatc 10980 cttacaatca tggtactaag
tacaatgaga agttcaaagg cagggccaca ctaactgcag 11040 acaaatccat
cagcacagcc tacatggagc tcagcagcct gcgctctgag gacactgcgg 11100
tctactactg tgcaagatca ggaccctatg cctggtttga cacctggggc caagggacca
11160 cggtcaccgt ctcctcaggt aagaatggcc actctagggc ctttgttttc
tgctgctgcc 11220 tgtgggattt catgagcatt gcaaagttgt cctcgggaca
tgttccgagg ggacctgggc 11280 ggactggcca ggaggggacg ggcactgggg
tgccttgagg atctgggagc ctctgtggat 11340 tttccgatgc ctttggaaaa
tgggactgag gttgggtgcg tctgagacag taactcagcc 11400 tgggggcttg
gtgaagatcg ccgcacagca gcgagtccgt gaaatatctt atttagactt 11460
gtgaggtgcg ctgtgtgtca atttacatct taaatccttt attggctgga aagagaattg
11520 ttggagtggg tgaatccagc caggagggac gcggggggat cca 11563
<210> SEQ ID NO 38 <211> LENGTH: 11563 <212>
TYPE: DNA <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: synthetic expression vector
<220> FEATURE: <223> OTHER INFORMATION: Nucleotide
sequence of the expression vector HCVHQN73DSp20 <400>
SEQUENCE: 38 ctagagaggt ctggtggagc ctgcaaaagt ccagctttca aaggaacaca
gaagtatgtg 60 tatggaatat tagaagatgt tgcttttact cttaagttgg
ttcctaggaa aaatagttaa 120 atactgtgac tttaaaatgt gagagggttt
tcaagtactc atttttttaa atgtccaaaa 180 tttttgtcaa tcaatttgag
gtcttgtttg tgtagaactg acattactta aagtttaacc 240 gaggaatggg
agtgaggctc tctcataccc tattcagaac tgacttttaa caataataaa 300
ttaagtttaa aatattttta aatgaattga gcaatgttga gttggagtca agatggccga
360 tcagaaccag aacacctgca gcagctggca ggaagcaggt catgtggcaa
ggctatttgg 420 ggaagggaaa ataaaaccac taggtaaact tgtagctgtg
gtttgaagaa gtggttttga 480 aacactctgt ccagccccac caaaccgaaa
gtccaggctg agcaaaacac cacctgggta 540 atttgcattt ctaaaataag
ttgaggattc agccgaaact ggagaggtcc tcttttaact 600 tattgagttc
aaccttttaa ttttagcttg agtagttcta gtttccccaa acttaagttt 660
atcgacttct aaaatgtatt taagctttct ggggcaggcc aggcctgacc ttggctttgg
720 ggcagggagg gggctaaggt gaggcaggtg gcgccagcca ggtgcacacc
caatgcccat 780 gagcccagac actggacgct gaacctcgcg gacagttaag
aacccagggg cctctgcgcc 840 ctgggcccag ctctgtccca caccgcggtc
acatggcacc acctctcttg cagcctccac 900 caagggccca tcggtcttcc
ccctggcacc ctcctccaag agcacctctg ggggcacagc 960 ggccctgggc
tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc 1020
aggcgccctg accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta
1080 ctccctcagc agcgtggtga ccgtgccctc cagcagcttg ggcacccaga
cctacatctg 1140 caacgtgaat cacaagccca gcaacaccaa ggtggacaag
agagttggtg agaggccagc 1200 acagggaggg agggtgtctg ctggaagcca
ggctcagcgc tcctgcctgg acgcatcccg 1260 gctatgcagt cccagtccag
ggcagcaagg caggccccgt ctgcctcttc acccggaggc 1320 ctctgcccgc
cccactcatg ctcagggaga gggtcttctg gctttttccc caggctctgg 1380
gcaggcacag gctaggtgcc cctaacccag gccctgcaca caaaggggca ggtgctgggc
1440 tcagacctgc caagagccat atccgggagg accctgcccc tgacctaagc
ccaccccaaa 1500 ggccaaactc tccactccct cagctcggac accttctctc
ctcccagatt ccagtaactc 1560 ccaatcttct ctctgcagag cccaaatctt
gtgacaaaac tcacacatgc ccaccgtgcc 1620 caggtaagcc agcccaggcc
tcgccctcca gctcaaggcg ggacaggtgc cctagagtag 1680 cctgcatcca
gggacaggcc ccagccgggt gctgacacgt ccacctccat ctcttcctca 1740
gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc
1800 ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag
ccacgaagac 1860 cctgaggtca agttcaactg gtacgtggac ggcgtggagg
tgcataatgc caagacaaag 1920 ccgcgggagg agcagtacaa cagcacgtac
cgtgtggtca gcgtcctcac cgtcctgcac 1980 caggactggc tgaatggcaa
ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc 2040 cccatcgaga
aaaccatctc caaagccaaa ggtgggaccc gtggggtgcg agggccacat 2100
ggacagaggc cggctcggcc caccctctgc cctgagagtg accgctgtac caacctctgt
2160 ccctacaggg cagccccgag aaccacaggt gtacaccctg cccccatccc
gggaggagat 2220 gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc
ttctatccca gcgacatcgc 2280 cgtggagtgg gagagcaatg ggcagccgga
gaacaactac aagaccacgc ctcccgtgct 2340 ggactccgac ggctccttct
tcctctatag caagctcacc gtggacaaga gcaggtggca 2400 gcaggggaac
gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca 2460
gaagagcctc tccctgtccc cgggtaaatg agtgcgacgg ccggcaagcc cccgctcccc
2520 gggctctcgc ggtcgcacga ggatgcttgg cacgtacccc gtctacatac
ttcccaggca 2580 cccagcatgg aaataaagca cccaccactg ccctgggccc
ctgcgagact gtgatggttc 2640 tttccacggg tcaggccgag tctgaggcct
gagtggcatg agggaggcag agcgggtccc 2700 actgtcccca cactggccca
ggctgtgcag gtgtgcctgg gccgcctagg gtggggctca 2760 gccaggggct
gccctcggca gggtggggga tttgccagcg tggccctccc tccagcagca 2820
gctgccctgg gctgggccac gagaagccct aggagcccct ggggacagac acacagcccc
2880 tgcctctgta ggagactgtc ctgtcctgtg agcgccctgt cctccgaccc
cgatgcccac 2940 tcgggggcat gcctagtcca tgcgcgtagg gacaggccct
ccctcaccca tctaccccca 3000 cggcactaac ccctggcagc cctgcccagc
ctcgcacccg catggggaca caaccgactc 3060 cggggacatg cactctcggg
ccctgtggag ggactggtgc agatgcccac acacacactc 3120 agcccagacc
cgttcaacaa accccgcact gaggttggtc gagcgggagt gcggccagag 3180
cctgcctcgg ccgtcaggga ggactcccgg gctcactcga aggaggtgcc accatttcag
3240 ctttggtagc ttttcttctt cttttaaatt ttctaaagct cattaattgt
ctttgatgtt 3300 tcttttgtga tgacaataaa atatcctttt taagtcttgt
acttcgtgat gggagccgcc 3360 ttcctgtgtc cacgcgcctc ctgcccccgg
tgggaagcac ggtcaggagg aggctggtcc 3420 agctgcacct cgggggctcc
ctgcactcgc cccccgcctc ctgcagccac acgcattgcc 3480 cgagcgaccc
tccctggccc ctgtcactac atggacccct ggggcttctc ctcttttcta 3540
catggatgca gtttctcctc ctgctgggca cggtgctgcc tgccctggtc actctgcggg
3600 ggacagggcc tccagggaaa gctgggtcga ggctgggagc tggctcaggc
tggccaggca 3660 gagccacagg gagggccttc cagaaccaac catggtccga
agcgagaggt gggtgtcaga 3720 tccagacatg ataagataca ttgatgagtt
tggacaaacc acaactagaa tgcagtgaaa 3780 aaaatgcttt atttgtgaaa
tttgtgatgc tattgcttta tttgtaacca ttataagctg 3840 caataaacaa
gttaacaaca acaattgcat tcattttatg tttcaggttc agggggaggt 3900
gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtatggctg attatgatct
3960 ctagtcaagg cactatacat caaatattcc ttattaaccc ctttacaaat
taaaaagcta 4020 aaggtacaca atttttgagc atagttatta atagcagaca
ctctatgcct gtgtggagta 4080 agaaaaaaca gtatgttatg attataactg
ttatgcctac ttataaaggt tacagaatat 4140 ttttccataa ttttcttgta
tagcagtgca gctttttcct ttgtggtgta aatagcaaag 4200 caagcaagag
ttctattact aaacacagca tgactcaaaa aacttagcaa ttctgaagga 4260
aagtccttgg ggtcttctac ctttctcttc ttttttggag gagtagaatg ttgagagtca
4320 gcagtagcct catcatcact agatggcatt tcttctgagc aaaacaggtt
ttcctcatta 4380 aaggcattcc accactgctc ccattcatca gttccatagg
ttggaatcta aaatacacaa 4440 acaattagaa tcagtagttt aacacattat
acacttaaaa attttatatt taccttagag 4500 ctttaaatct ctgtaggtag
tttgtccaat tatgtcacac cacagaagta aggttccttc 4560 acaaagatcc
ggaccaaagc ggccatcgtg cctccccact cctgcagttc gggggcatgg 4620
atgcgcggat agccgctgct ggtttcctgg atgccgacgg atttgcactg ccggtagaac
4680 tccgcgaggt cgtccagcct caggcagcag ctgaaccaac tcgcgagggg
atcgagcccg 4740 gggtgggcga agaactccag catgagatcc ccgcgctgga
ggatcatcca gccggcgtcc 4800 cggaaaacga ttccgaagcc caacctttca
tagaaggcgg cggtggaatc gaaatctcgt 4860 gatggcaggt tgggcgtcgc
ttggtcggtc atttcgaacc ccagagtccc gctcagaaga 4920 actcgtcaag
aaggcgatag aaggcgatgc gctgcgaatc gggagcggcg ataccgtaaa 4980
gcacgaggaa gcggtcagcc cattcgccgc caagctcttc agcaatatca cgggtagcca
5040 acgctatgtc ctgatagcgg tccgccacac ccagccggcc acagtcgatg
aatccagaaa 5100 agcggccatt ttccaccatg atattcggca agcaggcatc
gccatgggtc acgacgagat 5160 cctcgccgtc gggcatgcgc gccttgagcc
tggcgaacag ttcggctggc gcgagcccct 5220 gatgctcttc gtccagatca
tcctgatcga caagaccggc ttccatccga gtacgtgctc 5280 gctcgatgcg
atgtttcgct tggtggtcga atgggcaggt agccggatca agcgtatgca 5340
gccgccgcat tgcatcagcc atgatggata ctttctcggc aggagcaagg tgagatgaca
5400 ggagatcctg ccccggcact tcgcccaata gcagccagtc ccttcccgct
tcagtgacaa 5460 cgtcgagcac agctgcgcaa ggaacgcccg tcgtggccag
ccacgatagc cgcgctgcct 5520 cgtcctgcag ttcattcagg gcaccggaca
ggtcggtctt gacaaaaaga accgggcgcc 5580
cctgcgctga cagccggaac acggcggcat cagagcagcc gattgtctgt tgtgcccagt
5640 catagccgaa tagcctctcc acccaagcgg ccggagaacc tgcgtgcaat
ccatcttgtt 5700 caatcatgcg aaacgatcct catcctgtct cttgatcaga
tcttgatccc ctgcgccatc 5760 agatccttgg cggcaagaaa gccatccagt
ttactttgca gggcttccca accttaccag 5820 agggcgcccc agctggcaat
tccggttcgc ttgctgtcca taaaaccgcc cagtctagct 5880 atcgccatgt
aagcccactg caagctacct gctttctctt tgcgcttgcg ttttcccttg 5940
tccagatagc ccagtagctg acattcatcc ggggtcagca ccgtttctgc ggactggctt
6000 tctacgtgtt ccgcttcctt tagcagccct tgcgccctga gtgcttgcgg
cagcgtgaag 6060 ctttttgcaa aagcctaggc ctccaaaaaa gcctcctcac
tacttctgga atagctcaga 6120 ggccgaggcg gcctcggcct ctgcataaat
aaaaaaaatt agtcagccat ggggcggaga 6180 atgggcggaa ctgggcggag
ttaggggcgg gatgggcgga gttaggggcg ggactatggt 6240 tgctgactaa
ttgagatgca tgctttgcat acttctgcct gctggggagc ctggggactt 6300
tccacacctg gttgctgact aattgagatg catgctttgc atacttctgc ctgctgggga
6360 gcctggggac tttccacacc ctaactgaca cacattccac agctgcctcg
cgcgtttcgg 6420 tgatgacggt gaaaacctct gacacatgca gctcccggag
acggtcacag cttgtctgta 6480 agcggatgcc gggagcagac aagcccgtca
gggcgcgtca gcgggtgttg gcgggtgtcg 6540 gggcgcagcc atgacccagt
cacgtagcga tagcggagtg tatactggct taactatgcg 6600 gcatcagagc
agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc 6660
gtaaggagaa aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc
6720 tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat
acggttatcc 6780 acagaatcag gggataacgc aggaaagaac atgtgagcaa
aaggccagca aaaggccagg 6840 aaccgtaaaa aggccgcgtt gctggcgttt
ttccataggc tccgcccccc tgacgagcat 6900 cacaaaaatc gacgctcaag
tcagaggtgg cgaaacccga caggactata aagataccag 6960 gcgtttcccc
ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga 7020
tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg
7080 tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga
accccccgtt 7140 cagcccgacc gctgcgcctt atccggtaac tatcgtcttg
agtccaaccc ggtaagacac 7200 gacttatcgc cactggcagc agccactggt
aacaggatta gcagagcgag gtatgtaggc 7260 ggtgctacag agttcttgaa
gtggtggcct aactacggct acactagaag gacagtattt 7320 ggtatctgcg
ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc 7380
ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc
7440 agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga
cgctcagtgg 7500 aacgaaaact cacgttaagg gattttggtc atgagattat
caaaaaggat cttcacctag 7560 atccttttaa attaaaaatg aagttttaaa
tcaatctaaa gtatatatga gtaaacttgg 7620 tctgacagtt accaatgctt
aatcagtgag gcacctatct cagcgatctg tctatttcgt 7680 tcatccatag
ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca 7740
tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca
7800 gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac
tttatccgcc 7860 tccatccagt ctattaattg ttgccgggaa gctagagtaa
gtagttcgcc agttaatagt 7920 ttgcgcaacg ttgttgccat tgctgcaggc
atcgtggtgt cacgctcgtc gtttggtatg 7980 gcttcattca gctccggttc
ccaacgatca aggcgagtta catgatcccc catgttgtgc 8040 aaaaaagcgg
ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg 8100
ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga
8160 tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg
tatgcggcga 8220 ccgagttgct cttgcccggc gtcaacacgg gataataccg
cgccacatag cagaacttta 8280 aaagtgctca tcattggaaa acgttcttcg
gggcgaaaac tctcaaggat cttaccgctg 8340 ttgagatcca gttcgatgta
acccactcgt gcacccaact gatcttcagc atcttttact 8400 ttcaccagcg
tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata 8460
agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt
8520 tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa
aaataaacaa 8580 ataggggttc cgcgcacatt tccccgaaaa gtgccacctg
acgtctaaga aaccattatt 8640 atcatgacat taacctataa aaataggcgt
atcacgaggc cctttcgtct tcaagaattc 8700 gagctcggta cccatcagcc
aaaaagcatg cctgccacac aacatcaatt tctggaaaac 8760 gctacactta
attatttcta gtagaacagc tctttggttt gccaaaaaga atcacctata 8820
gtggcatcta agcacaaaaa ggagaaaaaa atcacaaaga aatgattgag aggcataata
8880 aaaattatca aaaaattatg agttttacga tttcatcttt ttccaagttg
aaatcatagg 8940 gtggctttaa cacagtgaca aggaatgtgc atgctgccat
tatggtgctc tgcctaaaat 9000 ggttggagcc ttgtcatgct acagagaaac
tgtcatacag cagggggtgc caaatttcca 9060 tattttttta tatcattgag
caggtgcaca gaagaccaga aagcactttc tatcaggctg 9120 gccttcctct
tcctttccag tatgaagcaa aaactgccaa tgaaactagc aattgttaaa 9180
ttcctttttc aaacagtatt tgtgctatca gaacatagtg cattcaaaag tctagcctga
9240 gagaacaacc cagttttatt cattcctcct actacctctc tcattcccac
tgtttgtgtt 9300 ctccctccca ttttaattgt ctatctagtc caaactaagc
acacgatcca gtccacatta 9360 aacaacatgt tttcacttta agtcaaatac
aagacacctt taatatcagc ccttgttcat 9420 aatcgtgctt ctagtgactt
aatgtacatg tcacactgta ctgttgggtt ttgtgtctca 9480 tcatgaacaa
tgttgtgaag gtattaagtg gagagtaagc agaattagat tcctctaatg 9540
atgcacaccc acactaagag cagaaataat attaaaaata gaaaaaaaag ttttacatga
9600 gatttcaaat acccaggtat gagctgcagt ttcttcaagt taaagcatcg
aggttgtcag 9660 ttacactatt acaggaaaca tatgcagagt ttttatttta
gtatattagt tttcacatat 9720 gtggaattac tattaaacta ttctttcttt
tcaaatgctt accattgtaa atgagtttgt 9780 gactttgtgt aggtgagtgc
acatgactct ggatgcctaa gaggactgaa gaagttggag 9840 ttataggtag
ttttattcta cttgactgtt cagtgctaaa aatacaactg aggtccttta 9900
aactgctgtt catgaacttc ttaattgata tatctcatga gatctctaaa ctatttttat
9960 tatgacacgt ttcaccattt tcactgtaac gatttttatg ttttatatta
atgtaactat 10020 atgacacttc ccaaaatccc catattcaca attgaactgt
ttcaaagttt taccttgact 10080 tatgggaaat gaaaacccac attttataat
tttaaaatga aatgtttatt ttatatttct 10140 gcaaatttca caaggaaaga
ttagtcactg gtgtgtgaga gcagaggagc ataagagttc 10200 aggaatagaa
tccattatga ttctggaggc aaggaagaac tgatgccaag gtttcagtat 10260
aagagcagta tccactggaa aggataaagt cactacatct gagcacagag caggacatct
10320 acataatgag tggtcactaa tgggccactg ttacactgtt atatgtataa
ggctcaagaa 10380 tgagcactga ggctgtaagg tgtatgggtg aggacatcag
gatgtaaacc cagctcaggt 10440 agaggactca gaggacagca cagtcagcat
gaactaataa acatcagata agataaggca 10500 caagctcagc tatatagggt
aagggatctt tgtaaatctg attgtgcatc cagtctagtt 10560 caatgtgact
taggaagccc agtcatatgc aaatctagag aagactttag agtagaaatc 10620
tgaggctcac ctcacatacc agcaagcgag tgaccagtta gtcttaaggc accacttctt
10680 agacatcatg gcttgggtgt ggaccttgcc attcctgatg gcagctgccc
aaagtaagac 10740 atcagaaaaa agagttccaa ggggaattga agcagttcca
tgaatactca ccttcctgtg 10800 ttcttttcac aggtgtccag gcacaggtgc
agctggtgga gtcaggagcc gaagtgaaaa 10860 agcctggggc ttcagtgaag
gtgtcctgca aggcctctgg atacacattc actaattata 10920 ttatccactg
ggtgaagcag gagcctggtc agggccttga atggattgga tattttaatc 10980
cttacaatca tggtactaag tacaatgaga agttcaaagg cagggccaca ctaactgcag
11040 acaaatccat cagcacagcc tacatggagc tcagcagcct gcgctctgag
gacactgcgg 11100 tctactactg tgcaagatca ggaccctatg cctggtttga
cacctggggc caagggacca 11160 cggtcaccgt ctcctcaggt aagaatggcc
actctagggc ctttgttttc tgctgctgcc 11220 tgtgggattt catgagcatt
gcaaagttgt cctcgggaca tgttccgagg ggacctgggc 11280 ggactggcca
ggaggggacg ggcactgggg tgccttgagg atctgggagc ctctgtggat 11340
tttccgatgc ctttggaaaa tgggactgag gttgggtgcg tctgagacag taactcagcc
11400 tgggggcttg gtgaagatcg ccgcacagca gcgagtccgt gaaatatctt
atttagactt 11460 gtgaggtgcg ctgtgtgtca atttacatct taaatccttt
attggctgga aagagaattg 11520 ttggagtggg tgaatccagc caggagggac
gcggggggat cca 11563 <210> SEQ ID NO 39 <211> LENGTH:
8096 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: synthetic
expression vector <220> FEATURE: <223> OTHER
INFORMATION: Nucleotide sequence of expression vector LCVL2Sp20
<400> SEQUENCE: 39 ctagagtcct agagaggtct ggtggagcct
gcaaaagtcc agctttcaaa ggaacacaga 60 agtatgtgta tggaatatta
gaagatgttg cttttactct taagttggtt cctaggaaaa 120 atagttaaat
actgtgactt taaaatgtga gagggttttc aagtactcat ttttttaaat 180
gtccaaaatt tttgtcaatc aatttgaggt cttgtttgtg tagaactgac attacttaaa
240 gtttaaccga ggaatgggag tgaggctctc tcatacccta ttcagaactg
acttttaaca 300 ataataaatt aagtttaaaa tatttttaaa tgaattgagc
aatgttgagt tggagtcaag 360 atggccgatc agaaccagaa cacctgcagc
agctggcagg aagcaggtca tgtggcaagg 420 ctatttgggg aagggaaaat
aaaaccacta ggtaaacttg tagctgtggt ttgaagaagt 480 ggttttgaaa
cactctgtcc agccccacca aaccgaaagt ccaggctgag caaaacacca 540
cctgggtaat ttgcatttct aaaataagtt gaggattcag ccgaaactgg agaggtcctc
600 ttttaactta ttgagttcaa ccttttaatt ttagcttgag tagttctagt
ttccccaaac 660 ttaagtttat cgacttctaa aatgtattta gaactcattt
tcaaaattag gttatgtaag 720 aaattgaagg actttagtgt ctttaatttc
taatatattt agaaaacttc ttaaaattac 780 tctattattc ttccctctga
ttattggtct ccattcaatt cttttccaat acccgaagca 840 tttacagtga
ctttgttcat gatctttttt agttgtttgt tttgccttac tattaagact 900
ttgacattct ggtcaaaacg gcttcacaaa tctttttcaa gaccactttc tgagtattca
960 ttttaggaga aatacttttt ttttaaatga atgcaattat ctaggacctg
caggcatgct 1020 gttttctgtc tgtccctaac atgccctgtg attatccgca
aacaacacac ccaagggcag 1080 aactttgtta cttaaacacc atcctgtttg
cttctttcct caggaactgt ggctgcacca 1140
tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg
1200 tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt
ggataacgcc 1260 ctccaatcgg gtaactccca ggagagtgtc acagagcagg
acagcaagga cagcacctac 1320 agcctcagca gcaccctgac gctgagcaaa
gcagactacg agaaacacaa agtctacgcc 1380 tgcgaagtca cccatcaggg
cctgagctcg cccgtcacaa agagcttcaa caggggagag 1440 tgttagaggg
agaagtgccc ccacctgctc ctcagttcca gcctgacccc ctcccatcct 1500
ttggcctctg accctttttc cacaggggac ctacccctat tgcggtcctc cagctcatct
1560 ttcacctcac ccccctcctc ctccttggct ttaattatgc taatgttgga
ggagaatgaa 1620 taaataaagt gaatctttgc acctgtggtt tctctctttc
ctcatttaat aattattatc 1680 tgttgtttta ccaactactc aatttctctt
ataagggact aaatatgtag tcatcctaag 1740 gcgggatatc gagatctgaa
gctgatccag acatgataag atacattgat gagtttggac 1800 aaaccacaac
tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt gatgctattg 1860
ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat tgcattcatt
1920 ttatgtttca ggttcagggg gaggtgtggg aggtttttta aagcaagtaa
aacctctaca 1980 aatgtggtat ggctgattat gatctctagt caaggcacta
tacatcaaat attccttatt 2040 aaccccttta caaattaaaa agctaaaggt
acacaatttt tgagcatagt tattaatagc 2100 agacactcta tgcctgtgtg
gagtaagaaa aaacagtatg ttatgattat aactgttatg 2160 cctacttata
aaggttacag aatatttttc cataattttc ttgtatagca gtgcagcttt 2220
ttcctttgtg gtgtaaatag caaagcaagc aagagttcta ttactaaaca cagcatgact
2280 caaaaaactt agcaattctg aaggaaagtc cttggggtct tctacctttc
tcttcttttt 2340 tggaggagta gaatgttgag agtcagcagt agcctcatca
tcactagatg gcatttcttc 2400 tgagcaaaac aggttttcct cattaaaggc
attccaccac tgctcccatt catcagttcc 2460 ataggttgga atctaaaata
cacaaacaat tagaatcagt agtttaacac attatacact 2520 taaaaatttt
atatttacct tagagcttta aatctctgta ggtagtttgt ccaattatgt 2580
cacaccacag aagtaaggtt ccttcacaaa gatccggacc aaagcggcca tcgtgcctcc
2640 ccactcctgc agttcggggg catggatgcg cggatagccg ctgctggttt
cctggatgcc 2700 gacggatttg cactgccggt agaactccgc gaggtcgtcc
agcctcaggc agcagctgaa 2760 ccaactcgcg aggggatcga gcatccccca
tggtcttata aaaatgcata gctttaggag 2820 gggagcagag aacttgaaag
catcttcctg ttagtctttc ttctcgtaga cttcaaactt 2880 atacttgatg
cctttttcct cctggacctc agagaggacg cctgggtatt ctgggagaag 2940
tttatatttc cccaaatcaa tttctgggaa aaacgtgtca ctttcaaatt cctgcatgat
3000 ccttgtcaca aagagtctga ggtggcctgg ttgattcatg gcttcctggt
aaacagaact 3060 gcctccgact atccaaacca tgtctacttt acttgccaat
tccggttgtt caataagtct 3120 taaggcatca tccaaacttt tggcaagaaa
atgagctcct cgtggtggtt ctttgagttc 3180 tctactgaga actatattaa
ttctgtcctt taaaggtcga ttcttctcag gaatggagaa 3240 ccaggttttc
ctacccataa tcaccagatt ctgtttacct tccactgaag aggttgtggt 3300
cattctttgg aagtacttga actcgttcct gagcggaggc cagggtcggt ctccgttctt
3360 gccaatcccc atattttggg acacggcgac gatgcagttc aatggtcgaa
ccatgatggc 3420 agcggggata aaatcctacc agccttcacg ctaggattgc
cgtcaagttt gggggtaccg 3480 agctcgaatt agctttttgc aaaagcctag
gcctccaaaa aagcctcctc actacttctg 3540 gaatagctca gagggccgag
gcggcctcgg cctctgcata aataaaaaaa attagtcagc 3600 catggggcgg
agaatgggcg gaactgggcg gagttagggg cgggatgggc ggagttaggg 3660
gcgggactat ggttgctgac taattgagat gcatgctttg catacttctg cctgctgggg
3720 agcctgggga ctttccacac ctggttgctg actaattgag atgcatgctt
tgcatacttc 3780 tgcctgctgg ggagcctggg gactttccac accctaactg
acacacattc cacagctgcc 3840 tcgcgcgttt cggtgatgac ggtgaaaacc
tctgacacat gcagctcccg gagacggtca 3900 cagcttgtct gtaagcggat
gccgggagca gacaagcccg tcagggcgcg tcagcgggtg 3960 ttggcgggtg
tcggggcgca gccatgaccc agtcacgtag cgatagcgga gtgtatactg 4020
gcttaactat gcggcatcag agcagattgt actgagagtg caccatatgc ggccgcatat
4080 gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc
gctcttccgc 4140 ttcctcgctc actgactcgc tgcgctcggt cgttcggctg
cggcgagcgg tatcagctca 4200 ctcaaaggcg gtaatacggt tatccacaga
atcaggggat aacgcaggaa agaacatgtg 4260 agcaaaaggc cagcaaaagg
ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca 4320 taggctccgc
ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa 4380
cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc
4440 tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg
gaagcgtggc 4500 gctttctcat agctcacgct gtaggtatct cagttcggtg
taggtcgttc gctccaagct 4560 gggctgtgtg cacgaacccc ccgttcagcc
cgaccgctgc gccttatccg gtaactatcg 4620 tcttgagtcc aacccggtaa
gacacgactt atcgccactg gcagcagcca ctggtaacag 4680 gattagcaga
gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta 4740
cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg
4800 aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg
gtggtttttt 4860 tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct
caagaagatc ctttgatctt 4920 ttctacgggg tctgacgctc agtggaacga
aaactcacgt taagggattt tggtcatgag 4980 attatcaaaa aggatcttca
cctagatcct tttaaattaa aaatgaagtt ttaaatcaat 5040 ctaaagtata
tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc 5100
tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat
5160 aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac
cgcgagaccc 5220 acgctcaccg gctccagatt tatcagcaat aaaccagcca
gccggaaggg ccgagcgcag 5280 aagtggtcct gcaactttat ccgcctccat
ccagtctatt aattgttgcc gggaagctag 5340 agtaagtagt tcgccagtta
atagtttgcg caacgttgtt gccattgctg caggcatcgt 5400 ggtgtcacgc
tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg 5460
agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt
5520 tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac
tgcataattc 5580 tcttactgtc atgccatccg taagatgctt ttctgtgact
ggtgagtact caaccaagtc 5640 attctgagaa tagtgtatgc ggcgaccgag
ttgctcttgc ccggcgtcaa cacgggataa 5700 taccgcgcca catagcagaa
ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg 5760 aaaactctca
aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc 5820
caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag
5880 gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac
tcatactctt 5940 cctttttcaa tattattgaa gcatttatca gggttattgt
ctcatgagcg gatacatatt 6000 tgaatgtatt tagaaaaata aacaaatagg
ggttccgcgc acatttcccc gaaaagtgcc 6060 acctgacgtc taagaaacca
ttattatcat gacattaacc tataaaaata ggcgtatcac 6120 gaggcccttt
cgtcttcaag aattcagctg ctcgaggaag agctcaaacc catgctactc 6180
tctggcttga tggaagcaac gctttcatag ctgagctgtc ataaataata aagagatttt
6240 tttattaata ttgaaaagat gggttattta tgtaagactc tgtcttcatt
ttaaaaacca 6300 caccttccag tagtattctg ttactgttct ggcaatcact
gtgatcaaga agctacacgg 6360 tgagttgtgc ttctcagtcc taagggatac
atctacaaga ggctcccata ctcgaagctc 6420 aggaaacatt gtagaaaagg
aggcaaaaga ctgacagagc cagaggacca agaaatttgt 6480 tgtgaggttg
tgtctcctac taacaatata agcaatatct ataaattgtt gatatcatgg 6540
ctactaaaat gtgagttgaa cgaggaggac acaaatgaac atgacaatca gaatgaggcc
6600 tctcacctgc aaaaaacact atagagaagc agataaagct gtcagcagaa
gaggcgcacc 6660 tccttataga agaagcctac caggtttgat atatcagcct
tgaaaaccta catagtattt 6720 acattatatc gagtctatga gacatattta
gtaatgcata tgtatgtgtg tgtgtgcatg 6780 tatgtgtgta aatacatatg
ttcatagaaa aatgtgtaaa aagagatcat gaatttaaga 6840 gagaactggg
acaatttttt tcagggagtt gtaatcagga aagttaaggg aaaaatgttg 6900
taattaaaat tcaggctcag aaacaaacaa aggaaaagaa aaaaaaacaa caacaacaac
6960 aaaaaaacaa aacaaaggag aagctgtatg gccacaatag catctacagc
taactgtgaa 7020 aggataatgg aacaagttat gtactgccta gagcagtatg
atgcctaaat catctcgaca 7080 tggaggaaaa tagaacaaag acactctaca
tagactatga tagaaatcaa aataaggtgt 7140 aagacataga acattagttt
tgtttgttgt tcaaagagac tcacattccc acaaaaaaat 7200 ctgtgggatt
ttacaggtct gcaataagct gctgacctga tgatttctgc agctgtgcct 7260
accctttgct gatttgcatg tacccaaagc atagcttact gacatgagga tttcttcata
7320 gtcaggtcac accctttgct ggagtcagaa tcacactgat cacacacagt
catgagtgtg 7380 ctcactcagg tcctggcgtt gctgctgctg tggcttacag
gtaatgaaga cagcactaga 7440 attttattga gcttcctgta cactgtgctg
cttgtctctg tgaaaattct cttgtgaatt 7500 aatcatgtgg ggatctgttt
tcaatttttc aattgtaggt acgcgttgtg acattctgct 7560 gacccagtct
ccagccaccc tgtctctgag tccaggagaa agagccactt tctcctgcag 7620
ggccagtcag aacattggca caagcataca gtggtatcaa caaaaaacaa atggtgctcc
7680 aaggcttctc ataaggtctt cttctgagtc tatctctggg atcccttcca
ggtttagtgg 7740 cagtggatca gggacagatt ttactcttac catcagcagt
ctggagcctg aagattttgc 7800 agtgtattac tgtcaacaaa gtaatacctg
gccattcacg ttcggccagg ggaccaagct 7860 tgaaatcaaa cgtaagtaga
atccaaagtc tctttcttcc gttgtctatg tctgtggctt 7920 ctatgtctaa
aaatgatgta taaaatctta ctctgaaacc agattctggc actctccaag 7980
gcaaagatac agagtaactc cgtaagcaaa gctgggaata ggctagacat gttctctgga
8040 gaatgaatgc cagtgtaata attaacacaa gtgatagttt cagaaatgct ctagtt
8096 <210> SEQ ID NO 40 <211> LENGTH: 11563 <212>
TYPE: DNA <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: synthetic expression vector
<220> FEATURE: <223> OTHER INFORMATION: Nucleotide
sequence of expression vector HCVHESp20 <400> SEQUENCE: 40
ctagagaggt ctggtggagc ctgcaaaagt ccagctttca aaggaacaca gaagtatgtg
60 tatggaatat tagaagatgt tgcttttact cttaagttgg ttcctaggaa
aaatagttaa 120 atactgtgac tttaaaatgt gagagggttt tcaagtactc
atttttttaa atgtccaaaa 180
tttttgtcaa tcaatttgag gtcttgtttg tgtagaactg acattactta aagtttaacc
240 gaggaatggg agtgaggctc tctcataccc tattcagaac tgacttttaa
caataataaa 300 ttaagtttaa aatattttta aatgaattga gcaatgttga
gttggagtca agatggccga 360 tcagaaccag aacacctgca gcagctggca
ggaagcaggt catgtggcaa ggctatttgg 420 ggaagggaaa ataaaaccac
taggtaaact tgtagctgtg gtttgaagaa gtggttttga 480 aacactctgt
ccagccccac caaaccgaaa gtccaggctg agcaaaacac cacctgggta 540
atttgcattt ctaaaataag ttgaggattc agccgaaact ggagaggtcc tcttttaact
600 tattgagttc aaccttttaa ttttagcttg agtagttcta gtttccccaa
acttaagttt 660 atcgacttct aaaatgtatt taagctttct ggggcaggcc
aggcctgacc ttggctttgg 720 ggcagggagg gggctaaggt gaggcaggtg
gcgccagcca ggtgcacacc caatgcccat 780 gagcccagac actggacgct
gaacctcgcg gacagttaag aacccagggg cctctgcgcc 840 ctgggcccag
ctctgtccca caccgcggtc acatggcacc acctctcttg cagcctccac 900
caagggccca tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc
960 ggccctgggc tgcctggtca aggactactt ccccgaaccg gtgacggtgt
cgtggaactc 1020 aggcgccctg accagcggcg tgcacacctt cccggctgtc
ctacagtcct caggactcta 1080 ctccctcagc agcgtggtga ccgtgccctc
cagcagcttg ggcacccaga cctacatctg 1140 caacgtgaat cacaagccca
gcaacaccaa ggtggacaag agagttggtg agaggccagc 1200 acagggaggg
agggtgtctg ctggaagcca ggctcagcgc tcctgcctgg acgcatcccg 1260
gctatgcagt cccagtccag ggcagcaagg caggccccgt ctgcctcttc acccggaggc
1320 ctctgcccgc cccactcatg ctcagggaga gggtcttctg gctttttccc
caggctctgg 1380 gcaggcacag gctaggtgcc cctaacccag gccctgcaca
caaaggggca ggtgctgggc 1440 tcagacctgc caagagccat atccgggagg
accctgcccc tgacctaagc ccaccccaaa 1500 ggccaaactc tccactccct
cagctcggac accttctctc ctcccagatt ccagtaactc 1560 ccaatcttct
ctctgcagag cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc 1620
caggtaagcc agcccaggcc tcgccctcca gctcaaggcg ggacaggtgc cctagagtag
1680 cctgcatcca gggacaggcc ccagccgggt gctgacacgt ccacctccat
ctcttcctca 1740 gcacctgaac tcctgggggg accgtcagtc ttcctcttcc
ccccaaaacc caaggacacc 1800 ctcatgatct cccggacccc tgaggtcaca
tgcgtggtgg tggacgtgag ccacgaagac 1860 cctgaggtca agttcaactg
gtacgtggac ggcgtggagg tgcataatgc caagacaaag 1920 ccgcgggagg
agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac 1980
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc
2040 cccatcgaga aaaccatctc caaagccaaa ggtgggaccc gtggggtgcg
agggccacat 2100 ggacagaggc cggctcggcc caccctctgc cctgagagtg
accgctgtac caacctctgt 2160 ccctacaggg cagccccgag aaccacaggt
gtacaccctg cccccatccc gggaggagat 2220 gaccaagaac caggtcagcc
tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc 2280 cgtggagtgg
gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct 2340
ggactccgac ggctccttct tcctctatag caagctcacc gtggacaaga gcaggtggca
2400 gcaggggaac gtcttctcat gctccgtgat gcatgaggct ctgcacaacc
actacacgca 2460 gaagagcctc tccctgtccc cgggtaaatg agtgcgacgg
ccggcaagcc cccgctcccc 2520 gggctctcgc ggtcgcacga ggatgcttgg
cacgtacccc gtctacatac ttcccaggca 2580 cccagcatgg aaataaagca
cccaccactg ccctgggccc ctgcgagact gtgatggttc 2640 tttccacggg
tcaggccgag tctgaggcct gagtggcatg agggaggcag agcgggtccc 2700
actgtcccca cactggccca ggctgtgcag gtgtgcctgg gccgcctagg gtggggctca
2760 gccaggggct gccctcggca gggtggggga tttgccagcg tggccctccc
tccagcagca 2820 gctgccctgg gctgggccac gagaagccct aggagcccct
ggggacagac acacagcccc 2880 tgcctctgta ggagactgtc ctgtcctgtg
agcgccctgt cctccgaccc cgatgcccac 2940 tcgggggcat gcctagtcca
tgcgcgtagg gacaggccct ccctcaccca tctaccccca 3000 cggcactaac
ccctggcagc cctgcccagc ctcgcacccg catggggaca caaccgactc 3060
cggggacatg cactctcggg ccctgtggag ggactggtgc agatgcccac acacacactc
3120 agcccagacc cgttcaacaa accccgcact gaggttggtc gagcgggagt
gcggccagag 3180 cctgcctcgg ccgtcaggga ggactcccgg gctcactcga
aggaggtgcc accatttcag 3240 ctttggtagc ttttcttctt cttttaaatt
ttctaaagct cattaattgt ctttgatgtt 3300 tcttttgtga tgacaataaa
atatcctttt taagtcttgt acttcgtgat gggagccgcc 3360 ttcctgtgtc
cacgcgcctc ctgcccccgg tgggaagcac ggtcaggagg aggctggtcc 3420
agctgcacct cgggggctcc ctgcactcgc cccccgcctc ctgcagccac acgcattgcc
3480 cgagcgaccc tccctggccc ctgtcactac atggacccct ggggcttctc
ctcttttcta 3540 catggatgca gtttctcctc ctgctgggca cggtgctgcc
tgccctggtc actctgcggg 3600 ggacagggcc tccagggaaa gctgggtcga
ggctgggagc tggctcaggc tggccaggca 3660 gagccacagg gagggccttc
cagaaccaac catggtccga agcgagaggt gggtgtcaga 3720 tccagacatg
ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa 3780
aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg
3840 caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc
agggggaggt 3900 gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt
ggtatggctg attatgatct 3960 ctagtcaagg cactatacat caaatattcc
ttattaaccc ctttacaaat taaaaagcta 4020 aaggtacaca atttttgagc
atagttatta atagcagaca ctctatgcct gtgtggagta 4080 agaaaaaaca
gtatgttatg attataactg ttatgcctac ttataaaggt tacagaatat 4140
ttttccataa ttttcttgta tagcagtgca gctttttcct ttgtggtgta aatagcaaag
4200 caagcaagag ttctattact aaacacagca tgactcaaaa aacttagcaa
ttctgaagga 4260 aagtccttgg ggtcttctac ctttctcttc ttttttggag
gagtagaatg ttgagagtca 4320 gcagtagcct catcatcact agatggcatt
tcttctgagc aaaacaggtt ttcctcatta 4380 aaggcattcc accactgctc
ccattcatca gttccatagg ttggaatcta aaatacacaa 4440 acaattagaa
tcagtagttt aacacattat acacttaaaa attttatatt taccttagag 4500
ctttaaatct ctgtaggtag tttgtccaat tatgtcacac cacagaagta aggttccttc
4560 acaaagatcc ggaccaaagc ggccatcgtg cctccccact cctgcagttc
gggggcatgg 4620 atgcgcggat agccgctgct ggtttcctgg atgccgacgg
atttgcactg ccggtagaac 4680 tccgcgaggt cgtccagcct caggcagcag
ctgaaccaac tcgcgagggg atcgagcccg 4740 gggtgggcga agaactccag
catgagatcc ccgcgctgga ggatcatcca gccggcgtcc 4800 cggaaaacga
ttccgaagcc caacctttca tagaaggcgg cggtggaatc gaaatctcgt 4860
gatggcaggt tgggcgtcgc ttggtcggtc atttcgaacc ccagagtccc gctcagaaga
4920 actcgtcaag aaggcgatag aaggcgatgc gctgcgaatc gggagcggcg
ataccgtaaa 4980 gcacgaggaa gcggtcagcc cattcgccgc caagctcttc
agcaatatca cgggtagcca 5040 acgctatgtc ctgatagcgg tccgccacac
ccagccggcc acagtcgatg aatccagaaa 5100 agcggccatt ttccaccatg
atattcggca agcaggcatc gccatgggtc acgacgagat 5160 cctcgccgtc
gggcatgcgc gccttgagcc tggcgaacag ttcggctggc gcgagcccct 5220
gatgctcttc gtccagatca tcctgatcga caagaccggc ttccatccga gtacgtgctc
5280 gctcgatgcg atgtttcgct tggtggtcga atgggcaggt agccggatca
agcgtatgca 5340 gccgccgcat tgcatcagcc atgatggata ctttctcggc
aggagcaagg tgagatgaca 5400 ggagatcctg ccccggcact tcgcccaata
gcagccagtc ccttcccgct tcagtgacaa 5460 cgtcgagcac agctgcgcaa
ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct 5520 cgtcctgcag
ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc 5580
cctgcgctga cagccggaac acggcggcat cagagcagcc gattgtctgt tgtgcccagt
5640 catagccgaa tagcctctcc acccaagcgg ccggagaacc tgcgtgcaat
ccatcttgtt 5700 caatcatgcg aaacgatcct catcctgtct cttgatcaga
tcttgatccc ctgcgccatc 5760 agatccttgg cggcaagaaa gccatccagt
ttactttgca gggcttccca accttaccag 5820 agggcgcccc agctggcaat
tccggttcgc ttgctgtcca taaaaccgcc cagtctagct 5880 atcgccatgt
aagcccactg caagctacct gctttctctt tgcgcttgcg ttttcccttg 5940
tccagatagc ccagtagctg acattcatcc ggggtcagca ccgtttctgc ggactggctt
6000 tctacgtgtt ccgcttcctt tagcagccct tgcgccctga gtgcttgcgg
cagcgtgaag 6060 ctttttgcaa aagcctaggc ctccaaaaaa gcctcctcac
tacttctgga atagctcaga 6120 ggccgaggcg gcctcggcct ctgcataaat
aaaaaaaatt agtcagccat ggggcggaga 6180 atgggcggaa ctgggcggag
ttaggggcgg gatgggcgga gttaggggcg ggactatggt 6240 tgctgactaa
ttgagatgca tgctttgcat acttctgcct gctggggagc ctggggactt 6300
tccacacctg gttgctgact aattgagatg catgctttgc atacttctgc ctgctgggga
6360 gcctggggac tttccacacc ctaactgaca cacattccac agctgcctcg
cgcgtttcgg 6420 tgatgacggt gaaaacctct gacacatgca gctcccggag
acggtcacag cttgtctgta 6480 agcggatgcc gggagcagac aagcccgtca
gggcgcgtca gcgggtgttg gcgggtgtcg 6540 gggcgcagcc atgacccagt
cacgtagcga tagcggagtg tatactggct taactatgcg 6600 gcatcagagc
agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc 6660
gtaaggagaa aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc
6720 tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat
acggttatcc 6780 acagaatcag gggataacgc aggaaagaac atgtgagcaa
aaggccagca aaaggccagg 6840 aaccgtaaaa aggccgcgtt gctggcgttt
ttccataggc tccgcccccc tgacgagcat 6900 cacaaaaatc gacgctcaag
tcagaggtgg cgaaacccga caggactata aagataccag 6960 gcgtttcccc
ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga 7020
tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg
7080 tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga
accccccgtt 7140 cagcccgacc gctgcgcctt atccggtaac tatcgtcttg
agtccaaccc ggtaagacac 7200 gacttatcgc cactggcagc agccactggt
aacaggatta gcagagcgag gtatgtaggc 7260 ggtgctacag agttcttgaa
gtggtggcct aactacggct acactagaag gacagtattt 7320 ggtatctgcg
ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc 7380
ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc
7440 agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga
cgctcagtgg 7500 aacgaaaact cacgttaagg gattttggtc atgagattat
caaaaaggat cttcacctag 7560 atccttttaa attaaaaatg aagttttaaa
tcaatctaaa gtatatatga gtaaacttgg 7620 tctgacagtt accaatgctt
aatcagtgag gcacctatct cagcgatctg tctatttcgt 7680 tcatccatag
ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca 7740
tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca
7800 gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac
tttatccgcc 7860 tccatccagt ctattaattg ttgccgggaa gctagagtaa
gtagttcgcc agttaatagt 7920 ttgcgcaacg ttgttgccat tgctgcaggc
atcgtggtgt cacgctcgtc gtttggtatg 7980 gcttcattca gctccggttc
ccaacgatca aggcgagtta catgatcccc catgttgtgc 8040 aaaaaagcgg
ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg 8100
ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga
8160 tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg
tatgcggcga 8220 ccgagttgct cttgcccggc gtcaacacgg gataataccg
cgccacatag cagaacttta 8280 aaagtgctca tcattggaaa acgttcttcg
gggcgaaaac tctcaaggat cttaccgctg 8340 ttgagatcca gttcgatgta
acccactcgt gcacccaact gatcttcagc atcttttact 8400 ttcaccagcg
tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata 8460
agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt
8520 tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa
aaataaacaa 8580 ataggggttc cgcgcacatt tccccgaaaa gtgccacctg
acgtctaaga aaccattatt 8640 atcatgacat taacctataa aaataggcgt
atcacgaggc cctttcgtct tcaagaattc 8700 gagctcggta cccatcagcc
aaaaagcatg cctgccacac aacatcaatt tctggaaaac 8760 gctacactta
attatttcta gtagaacagc tctttggttt gccaaaaaga atcacctata 8820
gtggcatcta agcacaaaaa ggagaaaaaa atcacaaaga aatgattgag aggcataata
8880 aaaattatca aaaaattatg agttttacga tttcatcttt ttccaagttg
aaatcatagg 8940 gtggctttaa cacagtgaca aggaatgtgc atgctgccat
tatggtgctc tgcctaaaat 9000 ggttggagcc ttgtcatgct acagagaaac
tgtcatacag cagggggtgc caaatttcca 9060 tattttttta tatcattgag
caggtgcaca gaagaccaga aagcactttc tatcaggctg 9120 gccttcctct
tcctttccag tatgaagcaa aaactgccaa tgaaactagc aattgttaaa 9180
ttcctttttc aaacagtatt tgtgctatca gaacatagtg cattcaaaag tctagcctga
9240 gagaacaacc cagttttatt cattcctcct actacctctc tcattcccac
tgtttgtgtt 9300 ctccctccca ttttaattgt ctatctagtc caaactaagc
acacgatcca gtccacatta 9360 aacaacatgt tttcacttta agtcaaatac
aagacacctt taatatcagc ccttgttcat 9420 aatcgtgctt ctagtgactt
aatgtacatg tcacactgta ctgttgggtt ttgtgtctca 9480 tcatgaacaa
tgttgtgaag gtattaagtg gagagtaagc agaattagat tcctctaatg 9540
atgcacaccc acactaagag cagaaataat attaaaaata gaaaaaaaag ttttacatga
9600 gatttcaaat acccaggtat gagctgcagt ttcttcaagt taaagcatcg
aggttgtcag 9660 ttacactatt acaggaaaca tatgcagagt ttttatttta
gtatattagt tttcacatat 9720 gtggaattac tattaaacta ttctttcttt
tcaaatgctt accattgtaa atgagtttgt 9780 gactttgtgt aggtgagtgc
acatgactct ggatgcctaa gaggactgaa gaagttggag 9840 ttataggtag
ttttattcta cttgactgtt cagtgctaaa aatacaactg aggtccttta 9900
aactgctgtt catgaacttc ttaattgata tatctcatga gatctctaaa ctatttttat
9960 tatgacacgt ttcaccattt tcactgtaac gatttttatg ttttatatta
atgtaactat 10020 atgacacttc ccaaaatccc catattcaca attgaactgt
ttcaaagttt taccttgact 10080 tatgggaaat gaaaacccac attttataat
tttaaaatga aatgtttatt ttatatttct 10140 gcaaatttca caaggaaaga
ttagtcactg gtgtgtgaga gcagaggagc ataagagttc 10200 aggaatagaa
tccattatga ttctggaggc aaggaagaac tgatgccaag gtttcagtat 10260
aagagcagta tccactggaa aggataaagt cactacatct gagcacagag caggacatct
10320 acataatgag tggtcactaa tgggccactg ttacactgtt atatgtataa
ggctcaagaa 10380 tgagcactga ggctgtaagg tgtatgggtg aggacatcag
gatgtaaacc cagctcaggt 10440 agaggactca gaggacagca cagtcagcat
gaactaataa acatcagata agataaggca 10500 caagctcagc tatatagggt
aagggatctt tgtaaatctg attgtgcatc cagtctagtt 10560 caatgtgact
taggaagccc agtcatatgc aaatctagag aagactttag agtagaaatc 10620
tgaggctcac ctcacatacc agcaagcgag tgaccagtta gtcttaaggc accacttctt
10680 agacatcatg gcttgggtgt ggaccttgcc attcctgatg gcagctgccc
aaagtaagac 10740 atcagaaaaa agagttccaa ggggaattga agcagttcca
tgaatactca ccttcctgtg 10800 ttcttttcac aggtgtccag gcagaggtgc
agctggtgga gtcaggagcc gaagtgaaaa 10860 agcctggggc ttcagtgaag
gtgtcctgca aggcctctgg atacacattc actaattata 10920 ttatccactg
ggtgaagcag gagcctggtc agggccttga atggattgga tattttaatc 10980
cttacaatca tggtactaag tacaatgaga agttcaaagg cagggccaca ctaactgcaa
11040 acaaatccat cagcacagcc tacatggagc tcagcagcct gcgctctgag
gacactgcgg 11100 tctactactg tgcaagatca ggaccctatg cctggtttga
cacctggggc caagggacca 11160 cggtcaccgt ctcctcaggt aagaatggcc
actctagggc ctttgttttc tgctgctgcc 11220 tgtgggattt catgagcatt
gcaaagttgt cctcgggaca tgttccgagg ggacctgggc 11280 ggactggcca
ggaggggacg ggcactgggg tgccttgagg atctgggagc ctctgtggat 11340
tttccgatgc ctttggaaaa tgggactgag gttgggtgcg tctgagacag taactcagcc
11400 tgggggcttg gtgaagatcg ccgcacagca gcgagtccgt gaaatatctt
atttagactt 11460 gtgaggtgcg ctgtgtgtca atttacatct taaatccttt
attggctgga aagagaattg 11520 ttggagtggg tgaatccagc caggagggac
gcggggggat cca 11563 <210> SEQ ID NO 41 <211> LENGTH:
11563 <212> TYPE: DNA <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: synthetic
expression vector <220> FEATURE: <223> OTHER
INFORMATION: Nucleotide sequence of expression vector HCVHQSp20
<400> SEQUENCE: 41 ctagagaggt ctggtggagc ctgcaaaagt
ccagctttca aaggaacaca gaagtatgtg 60 tatggaatat tagaagatgt
tgcttttact cttaagttgg ttcctaggaa aaatagttaa 120 atactgtgac
tttaaaatgt gagagggttt tcaagtactc atttttttaa atgtccaaaa 180
tttttgtcaa tcaatttgag gtcttgtttg tgtagaactg acattactta aagtttaacc
240 gaggaatggg agtgaggctc tctcataccc tattcagaac tgacttttaa
caataataaa 300 ttaagtttaa aatattttta aatgaattga gcaatgttga
gttggagtca agatggccga 360 tcagaaccag aacacctgca gcagctggca
ggaagcaggt catgtggcaa ggctatttgg 420 ggaagggaaa ataaaaccac
taggtaaact tgtagctgtg gtttgaagaa gtggttttga 480 aacactctgt
ccagccccac caaaccgaaa gtccaggctg agcaaaacac cacctgggta 540
atttgcattt ctaaaataag ttgaggattc agccgaaact ggagaggtcc tcttttaact
600 tattgagttc aaccttttaa ttttagcttg agtagttcta gtttccccaa
acttaagttt 660 atcgacttct aaaatgtatt taagctttct ggggcaggcc
aggcctgacc ttggctttgg 720 ggcagggagg gggctaaggt gaggcaggtg
gcgccagcca ggtgcacacc caatgcccat 780 gagcccagac actggacgct
gaacctcgcg gacagttaag aacccagggg cctctgcgcc 840 ctgggcccag
ctctgtccca caccgcggtc acatggcacc acctctcttg cagcctccac 900
caagggccca tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc
960 ggccctgggc tgcctggtca aggactactt ccccgaaccg gtgacggtgt
cgtggaactc 1020 aggcgccctg accagcggcg tgcacacctt cccggctgtc
ctacagtcct caggactcta 1080 ctccctcagc agcgtggtga ccgtgccctc
cagcagcttg ggcacccaga cctacatctg 1140 caacgtgaat cacaagccca
gcaacaccaa ggtggacaag agagttggtg agaggccagc 1200 acagggaggg
agggtgtctg ctggaagcca ggctcagcgc tcctgcctgg acgcatcccg 1260
gctatgcagt cccagtccag ggcagcaagg caggccccgt ctgcctcttc acccggaggc
1320 ctctgcccgc cccactcatg ctcagggaga gggtcttctg gctttttccc
caggctctgg 1380 gcaggcacag gctaggtgcc cctaacccag gccctgcaca
caaaggggca ggtgctgggc 1440 tcagacctgc caagagccat atccgggagg
accctgcccc tgacctaagc ccaccccaaa 1500 ggccaaactc tccactccct
cagctcggac accttctctc ctcccagatt ccagtaactc 1560 ccaatcttct
ctctgcagag cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc 1620
caggtaagcc agcccaggcc tcgccctcca gctcaaggcg ggacaggtgc cctagagtag
1680 cctgcatcca gggacaggcc ccagccgggt gctgacacgt ccacctccat
ctcttcctca 1740 gcacctgaac tcctgggggg accgtcagtc ttcctcttcc
ccccaaaacc caaggacacc 1800 ctcatgatct cccggacccc tgaggtcaca
tgcgtggtgg tggacgtgag ccacgaagac 1860 cctgaggtca agttcaactg
gtacgtggac ggcgtggagg tgcataatgc caagacaaag 1920 ccgcgggagg
agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac 1980
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc
2040 cccatcgaga aaaccatctc caaagccaaa ggtgggaccc gtggggtgcg
agggccacat 2100 ggacagaggc cggctcggcc caccctctgc cctgagagtg
accgctgtac caacctctgt 2160 ccctacaggg cagccccgag aaccacaggt
gtacaccctg cccccatccc gggaggagat 2220 gaccaagaac caggtcagcc
tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc 2280 cgtggagtgg
gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct 2340
ggactccgac ggctccttct tcctctatag caagctcacc gtggacaaga gcaggtggca
2400 gcaggggaac gtcttctcat gctccgtgat gcatgaggct ctgcacaacc
actacacgca 2460 gaagagcctc tccctgtccc cgggtaaatg agtgcgacgg
ccggcaagcc cccgctcccc 2520 gggctctcgc ggtcgcacga ggatgcttgg
cacgtacccc gtctacatac ttcccaggca 2580 cccagcatgg aaataaagca
cccaccactg ccctgggccc ctgcgagact gtgatggttc 2640 tttccacggg
tcaggccgag tctgaggcct gagtggcatg agggaggcag agcgggtccc 2700
actgtcccca cactggccca ggctgtgcag gtgtgcctgg gccgcctagg gtggggctca
2760 gccaggggct gccctcggca gggtggggga tttgccagcg tggccctccc
tccagcagca 2820 gctgccctgg gctgggccac gagaagccct aggagcccct
ggggacagac acacagcccc 2880 tgcctctgta ggagactgtc ctgtcctgtg
agcgccctgt cctccgaccc cgatgcccac 2940 tcgggggcat gcctagtcca
tgcgcgtagg gacaggccct ccctcaccca tctaccccca 3000 cggcactaac
ccctggcagc cctgcccagc ctcgcacccg catggggaca caaccgactc 3060
cggggacatg cactctcggg ccctgtggag ggactggtgc agatgcccac acacacactc
3120 agcccagacc cgttcaacaa accccgcact gaggttggtc gagcgggagt
gcggccagag 3180 cctgcctcgg ccgtcaggga ggactcccgg gctcactcga
aggaggtgcc accatttcag 3240 ctttggtagc ttttcttctt cttttaaatt
ttctaaagct cattaattgt ctttgatgtt 3300
tcttttgtga tgacaataaa atatcctttt taagtcttgt acttcgtgat gggagccgcc
3360 ttcctgtgtc cacgcgcctc ctgcccccgg tgggaagcac ggtcaggagg
aggctggtcc 3420 agctgcacct cgggggctcc ctgcactcgc cccccgcctc
ctgcagccac acgcattgcc 3480 cgagcgaccc tccctggccc ctgtcactac
atggacccct ggggcttctc ctcttttcta 3540 catggatgca gtttctcctc
ctgctgggca cggtgctgcc tgccctggtc actctgcggg 3600 ggacagggcc
tccagggaaa gctgggtcga ggctgggagc tggctcaggc tggccaggca 3660
gagccacagg gagggccttc cagaaccaac catggtccga agcgagaggt gggtgtcaga
3720 tccagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa
tgcagtgaaa 3780 aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta
tttgtaacca ttataagctg 3840 caataaacaa gttaacaaca acaattgcat
tcattttatg tttcaggttc agggggaggt 3900 gtgggaggtt ttttaaagca
agtaaaacct ctacaaatgt ggtatggctg attatgatct 3960 ctagtcaagg
cactatacat caaatattcc ttattaaccc ctttacaaat taaaaagcta 4020
aaggtacaca atttttgagc atagttatta atagcagaca ctctatgcct gtgtggagta
4080 agaaaaaaca gtatgttatg attataactg ttatgcctac ttataaaggt
tacagaatat 4140 ttttccataa ttttcttgta tagcagtgca gctttttcct
ttgtggtgta aatagcaaag 4200 caagcaagag ttctattact aaacacagca
tgactcaaaa aacttagcaa ttctgaagga 4260 aagtccttgg ggtcttctac
ctttctcttc ttttttggag gagtagaatg ttgagagtca 4320 gcagtagcct
catcatcact agatggcatt tcttctgagc aaaacaggtt ttcctcatta 4380
aaggcattcc accactgctc ccattcatca gttccatagg ttggaatcta aaatacacaa
4440 acaattagaa tcagtagttt aacacattat acacttaaaa attttatatt
taccttagag 4500 ctttaaatct ctgtaggtag tttgtccaat tatgtcacac
cacagaagta aggttccttc 4560 acaaagatcc ggaccaaagc ggccatcgtg
cctccccact cctgcagttc gggggcatgg 4620 atgcgcggat agccgctgct
ggtttcctgg atgccgacgg atttgcactg ccggtagaac 4680 tccgcgaggt
cgtccagcct caggcagcag ctgaaccaac tcgcgagggg atcgagcccg 4740
gggtgggcga agaactccag catgagatcc ccgcgctgga ggatcatcca gccggcgtcc
4800 cggaaaacga ttccgaagcc caacctttca tagaaggcgg cggtggaatc
gaaatctcgt 4860 gatggcaggt tgggcgtcgc ttggtcggtc atttcgaacc
ccagagtccc gctcagaaga 4920 actcgtcaag aaggcgatag aaggcgatgc
gctgcgaatc gggagcggcg ataccgtaaa 4980 gcacgaggaa gcggtcagcc
cattcgccgc caagctcttc agcaatatca cgggtagcca 5040 acgctatgtc
ctgatagcgg tccgccacac ccagccggcc acagtcgatg aatccagaaa 5100
agcggccatt ttccaccatg atattcggca agcaggcatc gccatgggtc acgacgagat
5160 cctcgccgtc gggcatgcgc gccttgagcc tggcgaacag ttcggctggc
gcgagcccct 5220 gatgctcttc gtccagatca tcctgatcga caagaccggc
ttccatccga gtacgtgctc 5280 gctcgatgcg atgtttcgct tggtggtcga
atgggcaggt agccggatca agcgtatgca 5340 gccgccgcat tgcatcagcc
atgatggata ctttctcggc aggagcaagg tgagatgaca 5400 ggagatcctg
ccccggcact tcgcccaata gcagccagtc ccttcccgct tcagtgacaa 5460
cgtcgagcac agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct
5520 cgtcctgcag ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga
accgggcgcc 5580 cctgcgctga cagccggaac acggcggcat cagagcagcc
gattgtctgt tgtgcccagt 5640 catagccgaa tagcctctcc acccaagcgg
ccggagaacc tgcgtgcaat ccatcttgtt 5700 caatcatgcg aaacgatcct
catcctgtct cttgatcaga tcttgatccc ctgcgccatc 5760 agatccttgg
cggcaagaaa gccatccagt ttactttgca gggcttccca accttaccag 5820
agggcgcccc agctggcaat tccggttcgc ttgctgtcca taaaaccgcc cagtctagct
5880 atcgccatgt aagcccactg caagctacct gctttctctt tgcgcttgcg
ttttcccttg 5940 tccagatagc ccagtagctg acattcatcc ggggtcagca
ccgtttctgc ggactggctt 6000 tctacgtgtt ccgcttcctt tagcagccct
tgcgccctga gtgcttgcgg cagcgtgaag 6060 ctttttgcaa aagcctaggc
ctccaaaaaa gcctcctcac tacttctgga atagctcaga 6120 ggccgaggcg
gcctcggcct ctgcataaat aaaaaaaatt agtcagccat ggggcggaga 6180
atgggcggaa ctgggcggag ttaggggcgg gatgggcgga gttaggggcg ggactatggt
6240 tgctgactaa ttgagatgca tgctttgcat acttctgcct gctggggagc
ctggggactt 6300 tccacacctg gttgctgact aattgagatg catgctttgc
atacttctgc ctgctgggga 6360 gcctggggac tttccacacc ctaactgaca
cacattccac agctgcctcg cgcgtttcgg 6420 tgatgacggt gaaaacctct
gacacatgca gctcccggag acggtcacag cttgtctgta 6480 agcggatgcc
gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg 6540
gggcgcagcc atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg
6600 gcatcagagc agattgtact gagagtgcac catatgcggt gtgaaatacc
gcacagatgc 6660 gtaaggagaa aataccgcat caggcgctct tccgcttcct
cgctcactga ctcgctgcgc 6720 tcggtcgttc ggctgcggcg agcggtatca
gctcactcaa aggcggtaat acggttatcc 6780 acagaatcag gggataacgc
aggaaagaac atgtgagcaa aaggccagca aaaggccagg 6840 aaccgtaaaa
aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat 6900
cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag
6960 gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc
gcttaccgga 7020 tacctgtccg cctttctccc ttcgggaagc gtggcgcttt
ctcatagctc acgctgtagg 7080 tatctcagtt cggtgtaggt cgttcgctcc
aagctgggct gtgtgcacga accccccgtt 7140 cagcccgacc gctgcgcctt
atccggtaac tatcgtcttg agtccaaccc ggtaagacac 7200 gacttatcgc
cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc 7260
ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt
7320 ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag
ctcttgatcc 7380 ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt
gcaagcagca gattacgcgc 7440 agaaaaaaag gatctcaaga agatcctttg
atcttttcta cggggtctga cgctcagtgg 7500 aacgaaaact cacgttaagg
gattttggtc atgagattat caaaaaggat cttcacctag 7560 atccttttaa
attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg 7620
tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt
7680 tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga
gggcttacca 7740 tctggcccca gtgctgcaat gataccgcga gacccacgct
caccggctcc agatttatca 7800 gcaataaacc agccagccgg aagggccgag
cgcagaagtg gtcctgcaac tttatccgcc 7860 tccatccagt ctattaattg
ttgccgggaa gctagagtaa gtagttcgcc agttaatagt 7920 ttgcgcaacg
ttgttgccat tgctgcaggc atcgtggtgt cacgctcgtc gtttggtatg 7980
gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc
8040 aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt
ggccgcagtg 8100 ttatcactca tggttatggc agcactgcat aattctctta
ctgtcatgcc atccgtaaga 8160 tgcttttctg tgactggtga gtactcaacc
aagtcattct gagaatagtg tatgcggcga 8220 ccgagttgct cttgcccggc
gtcaacacgg gataataccg cgccacatag cagaacttta 8280 aaagtgctca
tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg 8340
ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact
8400 ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa
aaagggaata 8460 agggcgacac ggaaatgttg aatactcata ctcttccttt
ttcaatatta ttgaagcatt 8520 tatcagggtt attgtctcat gagcggatac
atatttgaat gtatttagaa aaataaacaa 8580 ataggggttc cgcgcacatt
tccccgaaaa gtgccacctg acgtctaaga aaccattatt 8640 atcatgacat
taacctataa aaataggcgt atcacgaggc cctttcgtct tcaagaattc 8700
gagctcggta cccatcagcc aaaaagcatg cctgccacac aacatcaatt tctggaaaac
8760 gctacactta attatttcta gtagaacagc tctttggttt gccaaaaaga
atcacctata 8820 gtggcatcta agcacaaaaa ggagaaaaaa atcacaaaga
aatgattgag aggcataata 8880 aaaattatca aaaaattatg agttttacga
tttcatcttt ttccaagttg aaatcatagg 8940 gtggctttaa cacagtgaca
aggaatgtgc atgctgccat tatggtgctc tgcctaaaat 9000 ggttggagcc
ttgtcatgct acagagaaac tgtcatacag cagggggtgc caaatttcca 9060
tattttttta tatcattgag caggtgcaca gaagaccaga aagcactttc tatcaggctg
9120 gccttcctct tcctttccag tatgaagcaa aaactgccaa tgaaactagc
aattgttaaa 9180 ttcctttttc aaacagtatt tgtgctatca gaacatagtg
cattcaaaag tctagcctga 9240 gagaacaacc cagttttatt cattcctcct
actacctctc tcattcccac tgtttgtgtt 9300 ctccctccca ttttaattgt
ctatctagtc caaactaagc acacgatcca gtccacatta 9360 aacaacatgt
tttcacttta agtcaaatac aagacacctt taatatcagc ccttgttcat 9420
aatcgtgctt ctagtgactt aatgtacatg tcacactgta ctgttgggtt ttgtgtctca
9480 tcatgaacaa tgttgtgaag gtattaagtg gagagtaagc agaattagat
tcctctaatg 9540 atgcacaccc acactaagag cagaaataat attaaaaata
gaaaaaaaag ttttacatga 9600 gatttcaaat acccaggtat gagctgcagt
ttcttcaagt taaagcatcg aggttgtcag 9660 ttacactatt acaggaaaca
tatgcagagt ttttatttta gtatattagt tttcacatat 9720 gtggaattac
tattaaacta ttctttcttt tcaaatgctt accattgtaa atgagtttgt 9780
gactttgtgt aggtgagtgc acatgactct ggatgcctaa gaggactgaa gaagttggag
9840 ttataggtag ttttattcta cttgactgtt cagtgctaaa aatacaactg
aggtccttta 9900 aactgctgtt catgaacttc ttaattgata tatctcatga
gatctctaaa ctatttttat 9960 tatgacacgt ttcaccattt tcactgtaac
gatttttatg ttttatatta atgtaactat 10020 atgacacttc ccaaaatccc
catattcaca attgaactgt ttcaaagttt taccttgact 10080 tatgggaaat
gaaaacccac attttataat tttaaaatga aatgtttatt ttatatttct 10140
gcaaatttca caaggaaaga ttagtcactg gtgtgtgaga gcagaggagc ataagagttc
10200 aggaatagaa tccattatga ttctggaggc aaggaagaac tgatgccaag
gtttcagtat 10260 aagagcagta tccactggaa aggataaagt cactacatct
gagcacagag caggacatct 10320 acataatgag tggtcactaa tgggccactg
ttacactgtt atatgtataa ggctcaagaa 10380 tgagcactga ggctgtaagg
tgtatgggtg aggacatcag gatgtaaacc cagctcaggt 10440 agaggactca
gaggacagca cagtcagcat gaactaataa acatcagata agataaggca 10500
caagctcagc tatatagggt aagggatctt tgtaaatctg attgtgcatc cagtctagtt
10560 caatgtgact taggaagccc agtcatatgc aaatctagag aagactttag
agtagaaatc 10620 tgaggctcac ctcacatacc agcaagcgag tgaccagtta
gtcttaaggc accacttctt 10680 agacatcatg gcttgggtgt ggaccttgcc
attcctgatg gcagctgccc aaagtaagac 10740 atcagaaaaa agagttccaa
ggggaattga agcagttcca tgaatactca ccttcctgtg 10800
ttcttttcac aggtgtccag gcacaggtgc agctggtgga gtcaggagcc gaagtgaaaa
10860 agcctggggc ttcagtgaag gtgtcctgca aggcctctgg atacacattc
actaattata 10920 ttatccactg ggtgaagcag gagcctggtc agggccttga
atggattgga tattttaatc 10980 cttacaatca tggtactaag tacaatgaga
agttcaaagg cagggccaca ctaactgcaa 11040 acaaatccat cagcacagcc
tacatggagc tcagcagcct gcgctctgag gacactgcgg 11100 tctactactg
tgcaagatca ggaccctatg cctggtttga cacctggggc caagggacca 11160
cggtcaccgt ctcctcaggt aagaatggcc actctagggc ctttgttttc tgctgctgcc
11220 tgtgggattt catgagcatt gcaaagttgt cctcgggaca tgttccgagg
ggacctgggc 11280 ggactggcca ggaggggacg ggcactgggg tgccttgagg
atctgggagc ctctgtggat 11340 tttccgatgc ctttggaaaa tgggactgag
gttgggtgcg tctgagacag taactcagcc 11400 tgggggcttg gtgaagatcg
ccgcacagca gcgagtccgt gaaatatctt atttagactt 11460 gtgaggtgcg
ctgtgtgtca atttacatct taaatccttt attggctgga aagagaattg 11520
ttggagtggg tgaatccagc caggagggac gcggggggat cca 11563 <210>
SEQ ID NO 42 <211> LENGTH: 33 <212> TYPE: DNA
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: synthetic primer construct <220> FEATURE:
<223> OTHER INFORMATION: HuCD45LC-Mlu Primer <400>
SEQUENCE: 42 aaaacgcgtt gtgacattct gctgacccag tct 33 <210>
SEQ ID NO 43 <211> LENGTH: 31 <212> TYPE: DNA
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: synthetic primer construct <220> FEATURE:
<223> OTHER INFORMATION: HuCD45LC-Hind Primer <400>
SEQUENCE: 43 aaaaaagctt ggtcccctgg ccgaacgtga a 31 <210> SEQ
ID NO 44 <211> LENGTH: 27 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic primer construct <220> FEATURE:
<223> OTHER INFORMATION: HuCD45HCEup Primer <400>
SEQUENCE: 44 caggcagagg tgcagctggt ggagtca 27 <210> SEQ ID NO
45 <211> LENGTH: 27 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic primer construct <220> FEATURE:
<223> OTHER INFORMATION: HuCD45HCQup Primer <400>
SEQUENCE: 45 caggcacagg tgcagctggt ggagtca 27 <210> SEQ ID NO
46 <211> LENGTH: 29 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic primer construct <220> FEATURE:
<223> OTHER INFORMATION: HuCD45HClo Primer <400>
SEQUENCE: 46 aaatccttct agaactcacc tgaggagac 29 <210> SEQ ID
NO 47 <211> LENGTH: 20 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: recombinant protein <220> FEATURE: <223>
OTHER INFORMATION: Leader Sequence <400> SEQUENCE: 47 Met Asp
Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Val Ala Pro 1 5 10 15
Gly Ala His Ser 20 <210> SEQ ID NO 48 <211> LENGTH: 19
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: recombinant protein
<220> FEATURE: <223> OTHER INFORMATION: Leader Sequence
<400> SEQUENCE: 48 Met Ala Trp Val Trp Thr Leu Pro Phe Leu
Met Ala Ala Ala Gln Ser 1 5 10 15 Val Gln Ala <210> SEQ ID NO
49 <211> LENGTH: 35 <212> TYPE: DNA <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: synthetic primer construct <220> FEATURE:
<223> OTHER INFORMATION: aCD45H-N73D Primer <400>
SEQUENCE: 49 gccacactaa ctgcagacaa atccatcagc acagc 35
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