U.S. patent application number 12/757257 was filed with the patent office on 2010-12-16 for homeopathic complex.
Invention is credited to Daniel Farrington, Thomas Farrington.
Application Number | 20100316737 12/757257 |
Document ID | / |
Family ID | 40265986 |
Filed Date | 2010-12-16 |
United States Patent
Application |
20100316737 |
Kind Code |
A1 |
Farrington; Daniel ; et
al. |
December 16, 2010 |
HOMEOPATHIC COMPLEX
Abstract
The present invention is directed to a homeopathic complex for
use in the treatment of various diseases or disorders, including
use as an anti-infective agent and/or in the regeneration of
diseased or damaged tissue. Ideally, the anti-infective homeopathic
complex of the invention may comprise a homeopathic tincture or
dilutions thereof of Hepar sulphuris calcareum or other similar
profiled Calcarea or Sulphur salt or acid, Lachesis muta or other
remedy with a similar profile, Mercurius Solubilis or similar
mercury containing remedy and Silica or other silica containing
compounds.
Inventors: |
Farrington; Daniel; (New
York, NY) ; Farrington; Thomas; (Rosscarbery,
IE) |
Correspondence
Address: |
FROMMER LAWRENCE & HAUG
745 FIFTH AVENUE- 10TH FL.
NEW YORK
NY
10151
US
|
Family ID: |
40265986 |
Appl. No.: |
12/757257 |
Filed: |
April 9, 2010 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
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PCT/EP2008/008602 |
Oct 10, 2008 |
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12757257 |
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Current U.S.
Class: |
424/725 ;
556/400 |
Current CPC
Class: |
A61P 31/00 20180101;
A61K 36/185 20130101; A61K 35/02 20130101; A61K 35/58 20130101;
A61K 35/583 20130101; A61K 35/646 20130101; A61K 35/02 20130101;
A61K 35/646 20130101; A61K 41/0004 20130101; A61K 2300/00 20130101;
A61K 2300/00 20130101; A61K 2300/00 20130101; A61K 2300/00
20130101; A61K 2300/00 20130101; A61K 2300/00 20130101; A61K 33/04
20130101; A61K 2300/00 20130101; A61K 33/00 20130101; A61K 2300/00
20130101; A61K 36/185 20130101; A61K 35/58 20130101; A61K 33/28
20130101; A61K 33/28 20130101; A61K 33/06 20130101; A61K 33/00
20130101; A61K 33/04 20130101; A61K 33/06 20130101; A61K 45/06
20130101 |
Class at
Publication: |
424/725 ;
556/400 |
International
Class: |
A61K 36/00 20060101
A61K036/00; C07F 7/02 20060101 C07F007/02; A61P 31/00 20060101
A61P031/00 |
Foreign Application Data
Date |
Code |
Application Number |
Oct 10, 2007 |
IE |
2007/0737 |
Claims
1. An anti-infective homeopathic complex comprising a homeopathic
tincture or dilutions thereof of Hepar sulphuris calcareum or other
similar profiled Calcarea or Sulphur salt or acid, Lachesis muta or
other remedy with a similar profile, Mercurius Solubilis or similar
mercury containing remedy, and Silica or other silica containing
remedy.
2. A homeopathic complex according to claim 1 wherein Hepar
Sulphuris calcareum is replaced or supplemented with Calc Sulph or
Calc Sil
3. A homeopathic complex according to claim 1 wherein Lachesis muta
is replaced or supplemented with a snake or spider remedy with a
similar septic shock profile, preferably Crotalidae (Crotalus
Horridalus), Pyrogen and/or Tarantula Cubensis.
4. A homeopathic complex according to claim 1 wherein Mercurius
Solulbilis is replaced or supplemented with Phytolacca
decandra.
5. A homeopathic complex according to claim 1 in a potency range
from mother tincture to 100M, preferably from mother tincture to
50M.
6. A homeopathic complex according to claim 1 in LM potencies.
7. A homeopathic complex according to a claim 1 comprising a
homeopathic tincture or dilutions thereof of the Ranunculacea
family, preferably the Aconite or Aconitine, more preferably
Aconite napellus [Acon]; the Compositae family, preferably Arnica
montana [Arn]; Bellis perennis [Bell-p]; Calendula Offcinalis
[Calen]; Chamomilla Matricaria [Cham]; Millefolium achillea [Mill];
Carduus Marianus; and/or Echinacea, preferably Echinacea
angustifolia [Echi]; Echinacea purpurea [Echi-p]; the Solanacea
family, preferably Belladonna [Bell]; Arsenicum, preferably
Arsenicum iodatum [Ars-i] and/or Arsenicum Album; Bryonia alba
[Bry]; Hamamelis virginiana [Ham]; Hypericum Perforatum [Hyper];
Ledum palustre [Led]; Phytolacca decandra [Phyt]; the Anacardiacae
family preferably Rhus Toxicodendron [Rhus-T.]; the Rutaceae family
preferably Ruta Graveolans [Ruta]; Stellaria media [Stel]; and/or
Symphytum officinale [Symph].
8. A homeopathic complex according to claim 1 comprising a
homeopathic tincture or dilutions thereof of Aconite napellus
[Acon] Arnica montana [Arn]; Arsenicum iodatum [Ars-i]; Belladonna
[Bell]; Bellis perennis [Bell-p]; Bryonia alba [Bry]; Calenula
Offcinalis [Calen]; Echinacea angustifolia [Echi]; Echinacea
purpurea [Echi-p]; Hamamelis virginiana [Ham]; Hypericum Perforatum
[Hyper]; Ledum palustre [Led]; Millefolium achillea [Mill];
Phytolacca decandra [Phyt]; Rhus Toxicodendron [Rhus-T.]; Ruta
Graveolans [Ruta]; and Symphytum officinale [Symph].
9. A homeopathic complex according to claim 7 further comprising
optional Core B ingredients Thuja Occidentalis [Thuj], Chamomilla
Matricaria [Cham], Stellaria media [Stel] and/or Sulphur
[Sulph].
10. A homeopathic complex according to claim 7 further comprising
optional Core B ingredient Graphites naturalis.
11. A homeopathic complex according to claim 7 further comprising
Apis mellifica [Apis], Urtica urens [Urt-u], and Unbelliferae
preferably Conium maculatum and/or Gunpowder.
12. A homeopathic complex according to claim 1 further comprising a
homeopathic tincture or dilutions thereof of The Arsenicums,
preferably Arsenicum album [Ars]; The Barytas and Cabonicums,
preferably Baryta carbonica [Bar-c] and/or Kali Carbonicum; Carbo
vegetabilis [Carb-v]; The Calcareas, preferably Calcarea carbonica
[Calc]; Calcarea fluorica [Calc-f] and/or Calcarea phosphorica
[Calc-p]; Gelsemium sempervirens [Gels]; Iodium purum [Iod]; The
Kalis, preferably Kali iodatum [Kali-i] and/or Kali Carbonicum
Lacs, preferably Lac caninum [Lac-c]; Lac vaccinum and/or Lac
Vaccinum (cow); Lycopodium clavatum[Lyc]; The Natrums and
Muriatricums, preferably Natrum Mur Nux vomica [Nux-v]; Phosphorus,
preferably Phosphorus [Phos] and/or Ferrum Phos; the Ranunculacea
family, preferably Pulsatilla nigricans [Puls] and/or Staphysagria
[Staph]; Sabal serrulata [Sabal]; Sepia succus [Sep]; and/or
Zincums preferably Zincum metallicum [Zinc]. Baptisia tinctoria;
Pyrogen; Astragalus membranaceus; Bufo rana; and/or
Ipecacuanha.
13. A homeopathic complex according to claim 12 further comprising
Cantharis, Causticum, Crategus, Ferrum Phos and/or
Laurocerasus.
14. A homeopathic complex according to claim 1 further comprising a
homeopathic tincture or dilutions thereof of Adrenalin [Adren];
Aesculus hippocastanum [Aesc]; Alfalfa; Aurums; The Antimoniums,
preferably Antimonium Tart Berberis Vulgaris; Cactus Grandiflora;
Caladium seguinum [Calad]; Cantharis vesicatoria [Canth]; Carduus
Marianus; Cocculus indicus [Cocc]; Chelidonium; China officinalis;
Chionanthus virginica; Drosera rotundifolia; Equisetum hyemale;
Euphrasia: Galium Aprine; Grindelia; Histaminium (Histamine)
[Hist]; Hydrastis canadensis [Hydr]; Lappa Articum; Lavender
[Lav-v.]; Lobelia inflata; Mezereum [Mez]; Nitric acid [Nit-ac];
Paeonia Officinalis [Paeon]; Prednisolone [Predni.]; Ranunculus
bulbosus [Ran-b]; Rumex crispus [Rumx]; Solidago virgaurea;
Strophantus hispidus; Taraxacum officinale; Triticum Repens; The
Stannums preferably Stannum Met; Thiosinaminum [Thiosin]; Uva Ursi;
Veratrum Album; Cuprum met; and/or Sol [Sol].
15. An anti-infective homeopathic complex comprising a homeopathic
tincture and dilutions thereof comprising one or more of the
following ingredients: Hepar Sulph; Lachesis; Merc; Sil; Aconite
napellus; Arnica montana; Arsenicum iodatum; Belladonna; Bellis
perennis; Bryonia alba; Calenula Offcinalis; Chamomilla Matricaria;
Echinacea angustifolia; Echinacea purpurea; Graphites naturalis;
Hamamelis virginiana; Hypericum Perforatum; Ledum palustre;
Millefolium achillea; Phytolacca decandra; Rhus Toxicodendron; Ruta
Graveolans; Stellaria media; Sulphur; Symphytum officinale; Thuja
Occidentalis, Aconitum Napellus; Arnica Montana; Arsenicum Iod;
Belladonna; Bellis Perenis; Bryonia Alba; Calenula Offcinalis;
Chamomilla Matricaria; Conium maculatum; Echinacia augustofolia;
Echinacia Purpurea; Graphites Gunpowder; Hamamellis Virginia; Hepar
Sulphuris; Hypericum Perforatum; Lachesis; Ledum; Millefolium;
Mercurius Solubilis; Phytolacca decandra; Ruta Graveolans; Rhus
Toxicodendron; Silica [Sil]; Stellaria Media; Sulphur; Symphytum;
Thuja Occidentalis; and Urtica Urens.
16. An anti-infective homeopathic complex according to claim 15
wherein the homeopathic ingredients are provided in a potency range
from Mother tincture to 18.times..
17. An anti-infective homeopathic complex according to claim 15 in
a form suitable for topical administration.
18. An anti-infective homeopathic complex comprising a homeopathic
tincture and dilutions thereof of the following ingredients:
Aconite; Apis; Arnica Montana; Arsencium Iod; Belladonna; Bellis
Perennis; Bryonia; Calendula; Cantharis; Carbo Veg; Causticum;
Conium; Crategus; Echinacea Augustifolia; Echinacea Purpura; Ferrum
Phos; Gelsemium; Hammamellis; Hepar Sulph; Hypericum; Lachesis;
Laurocerasus; Ledum; Merc Sol; Millefolium; Nux Vomica; Phosphorus;
Phytolacca; Rhus Tox; Ruta Gray; Silica; Sulphur; Staphysagria;
Symphytum; Urtica; Chamomilla matrica; and Stellaria.
19. An anti-infective homeopathic complex according to claim 18
wherein the homeopathic ingredients are provided in a potency range
from 30 C and greater, preferably 200 C and greater and LM
potencies.
20. An anti-infective homeopathic complex according claim 18 in a
form suitable for internal administration.
Description
INCORPORATION BY REFERENCE
[0001] This application is a continuation-in-part application of
international patent application Serial No. PCT/EP2008/008602 filed
10 Oct. 2008, which published as PCT Publication No. WO 2009/047005
on 16 Apr. 2009, which claims benefit of Irish patent application
Serial No. 2007/0737 filed 10 Oct. 2007.
[0002] The foregoing applications, and all documents cited therein
or during their prosecution ("appln cited documents") and all
documents cited or referenced in the appln cited documents, and all
documents cited or referenced herein ("herein cited documents"),
and all documents cited or referenced in herein cited documents,
together with any manufacturer's instructions, descriptions,
product specifications, and product sheets for any products
mentioned herein or in any document incorporated by reference
herein, are hereby incorporated herein by reference, and may be
employed in the practice of the invention.
FIELD OF THE INVENTION
[0003] The present invention is directed to a homeopathic complex
for use in the treatment of various diseases or disorders,
particularly for use as an anti-infective agent and/or in the
regeneration of diseased or damaged tissue.
BACKGROUND OF THE INVENTION
[0004] Homeopathy is a form of alternative medicine and traditional
homeopathy has been practiced for nearly two hundred years all over
the world. Homeopathic medicine has its underpinnings in what is
referred to as the Law of Similars or the similia principle. The
fundamental principle of homeopathy states that substances may be
used to treat disorders whose manifestations are similar to those
which they themselves produce in a healthy subject (Churchill
Livingstone's International Dictionary of Homeopathy Edited by
Jeremy Swayne (2000) page 193, 1st Edition).
[0005] Homeopathic tinctures differ to herbal tinctures in their
method of production, base ingredients used and their dilution.
[0006] Homeopathic tinctures are derived from many materials,
whereas herbal tinctures are derived from plant materials only.
Homeopathic mother tinctures are made following monographs laid
down in the HAB (GHP--German Homeopathic Pharmacopeia), EP European
Pharmacopeia, French Homeopathic Pharmacopeia BHP British
Homeopathic Pharmacopeia HPUS Homeopathic Pharmacopeia of the
United States. While plants are the base ingredients for
approximately 65% of homeopathic tinctures, the remainder are made
from many mineral, animal or imponderable substances. Thus, the
production of a homeopathic tincture involves the use of base
ingredients from x-ray to diamond to Pulsatilla (the Wind
flower).
[0007] A homeopathic mother tincture, comprising base ingredients
such as for example fresh plants, is generally prepared by
extracting the ingredients in a suitable solvent, followed by the
steps of comminution, maceration and squeezing according to
accepted homeopathic Pharmacopoeia. Suitable solvents include
alcohol, water, water-alcohol mixtures, glycerine or isotonic
sodium chloride solutions. Other techniques include tituration
(grinding) with lactose to form a powdered dilution. On the
contrary herbal tinctures are prepared in a different manner
generally involving the use of a solvent to extract the base
ingredient without the maceration or grinding steps.
[0008] In homeopathy, a base preparation or mother tincture of a
homeopathic remedy is made by liquid extraction (via maceration) of
a herbal, mineral, animal or imponderable substance by dissolving
the herbal, mineral, animal or imponderable in a solvent. In use,
the mother tincture or 1.times. potency (1.times.10.sup.-1
dilution) may be used as is, for example in diseases where the
patient can benefit from the active principles within the tincture.
This assumes that the base tincture is not of a toxic nature.
Optionally, the mother tincture may be further diluted.
Essentially, a series of dilutions are prepared from the base
preparation or mother tincture. This step is called potentization
and involves a series of dilutions. Between each series the diluted
substance is succussed (shaken in a vigorous manner). The process
of dilution and succussion leads to a gradual loss of chemical
toxicity while gradually increasing the homeopathic potency. The
more dilute remedies being of greater potency.
[0009] Thus, homeopathic tinctures require a further dilution step
in the production of the mother homeopathic tincture. This means
that a homeopathic mother tincture is a 1.times. or 1 in 10
dilution of the base ingredient. Additionally, it is important to
note that it is not possible to reconstitute a herbal mother
tincture from a homeopathic mother tincture. Thus, what makes a
tincture truly homeopathic is the additional dilution process to
where the final mother tincture represents a dilution of 1:10 of
the base ingredient.
[0010] Thus, homeopathic tinctures differ to herbal remedies in
that a further dilution is required in the production of
homeopathic tinctures so that the base material is 10% of the final
mother tincture. As expanded on above a homeopathic mother tincture
from fresh plants is prepared by extracting the ingredients in a
suitable solvent, such as a alcohol, water-alcohol mixtures, water,
glycerine or isotonic sodium chloride solution are used as a
vehicle (solvent) followed by the steps of comminution, maceration
and squeezing. Other techniques include tituration (grinding) with
lactose to form a powdered dilution. On the other hand, herbal
remedies are less dilute than homeopathic remedies and are prepared
in a different manner merely involving the use of a solvent to
extract the ingredient.
[0011] Homeopathic preparations as defined above must follow the
monograph as laid down in the various homeopathic pharmacopoeias,
for example the German Homeopathic Pharmacopeia (G.H.P. or H.A.B.),
European Pharmacopeia (E.P.), French Homeopathic Pharmacopeia,
British Homeopathic Pharmacopeia (B.H.P.) or the Homeopathic
Pharmacopeia of the United States (H.P.U.S.).
[0012] The dilution and succussion level of homeopathic drugs are
denoted as "x", "X" or "d" for the decimal scale or centesimal "c",
"C" scale or LM (Q) as 1:50,000 dilutions. This is expanded in the
table below.
TABLE-US-00001 Decimal Centesimal POTENCY DILUTION CONCENTRATION
POTENCY DILUTION CONCENTRATION 1x or D1 1:10 10.sup.-1 6c
1:10.sup.12 1 .times. 10.sup.-12 2x or D2 1:100 10.sup.-2 7c
1:10.sup.14 1 .times. 10.sup.-14 3x or D3 1:1000 10.sup.-3 11c
1:10.sup.23 1 .times. 10.sup.-23 4x or D4 1:10000 10.sup.-4 12c
1:10.sup.24 1 .times. 10.sup.-24 5x or D5 1:100000 10.sup.-5 30c
1:10.sup.60 6x or D6 1:1000000 10.sup.-6 200c 1:10.sup.400 30x or
D30 1:10.sup.30 10.sup.-30 1M 1:10.sup.2000 10M 1:10.sup.20000 LM1
(Q) 3c diluted 1:50,000
[0013] For example, for a "3.times." preparation, the mother
tincture is diluted with nine parts of the desired diluent, in
either liquid or powder form. The resultant mixture is then diluted
a second time, in a ratio of one part mixture to ten parts solvent
and the resulting mixture is diluted a third time in a ratio of one
to ten. Therefore, the 3.times. or D3 potency is actually at
1.times.10.sup.-3 ( 1/1000) of the mother tincture. Similarly, a
6.times. potency dilution would be at 1.times.10.sup.-6 of the
original solution. In the "C scale" each dilution is done with
ninety-nine parts diluent to the original mixture. Therefore, a 3 C
potency dilution is at 1.times.10.sup.-6 potency of the original
mixture. Ideally,.times. potency dilution is usually carried out
with approximately 10 to 20 succussions, while C potency dilutions
are carried out with anywhere from 10 to 100 succussions and in
some cases 1000 succussions between dilutions. The more stages of
dilution and succussion a homeopathic solution has undergone, the
higher the potency of that remedy.
[0014] These x and C scales are recognized by the main Homeopathic
Pharmacopoeia such as the German Homeopathic Pharmacopoeia
(G.H.P.), French Homeopathic Pharmacopoeia British Homeopathic
Pharmacopoeia, the Homeopathic Pharmacopeia of the United States
(H.P.U.S.) and the European Homeopathic Pharmacopeia.
[0015] When choosing the homeopathic remedy to administer, it is
important to note that the homeopathic approach to treatment
hypothesizes that the closer the matching of symptoms of the
individual to be cured to those of the medicine being used, the
greater the curing effect of the homeopathic treatment. This
process is facilitated by these symptoms being catalogued in the
homeopathic Materia Medica and various Homeopathic Repertories. The
selection of the remedy is of prime importance in a successful
homeopathic treatment. Of secondary importance, is the selection of
the correct therapeutic potency. The potency of the medicine must
be matched to the state of the patient and the state of the disease
process. Thus, in a young healthy individual with an acute disease
process a high potency medicine would generally be appropriate,
whereas in an elderly patient with a chronic disease a low potency
or even a diluted LM potency may be more appropriate.
[0016] To demonstrate the effectiveness of a homeopathic drug, the
drug is tested by a "proving" in order to see how the drug will
affect an otherwise healthy person. Hundreds of compounds have been
tested in this manner and these are catalogued in the various
Homeopathic Repertories and Materia Medica. Homeopathic repertories
generally provide listings of the human anatomy (or in some
clinical repertories clinical conditions are listed) and list
associated symptoms and treatments for these symptoms. Materia
Medicae list homeopathic drugs and identify the maladies and
symptoms each drug treats. The material in the Materia Medicae is
derived from all the information about the homeopathic drug and
includes data from homeopathic provings, toxicity, and clinical
use. More over, where a repertory lists a symptom, it classifies
possible treating compounds as either first, second or third degree
and in some cases fourth degree remedies for that symptom.
Typically, a homeopathic practitioner will prescribe homeopathic
medicine that has the best overall recorded similarity to the
overall disease picture in the patient. This also involves taking
into account how important each symptom is in that picture
especially the strange rare and peculiar symptom(s), mental,
emotional, aetiological, general symptoms, local symptoms and
modalities. A homeopathic medicine with first degree indications
for a particular symptom picture is more likely to be used than a
remedy with a similar second degree picture unless the second
degree picture has a greater similarity to the overall patient
picture. A homeopathic medicine with a third degree indication
would be less likely to be used unless there was a greater
similarity and particularly if there was a strange rare and
peculiar symptom present. Homeopathic tinctures and their
derivative potencies or dilutions can be used in the treatment of a
wide variety of diseases, conditions and or symptoms.
[0017] Classical homeopathy involves the administration of a
homeopathic medicine based on a single ingredient. The use of a
homeopathic complex comprising multiple different ingredients is
contrary to conventional classical homeopathy teachings and in some
pharmacopoeia this is not recommended ("Hahnemann Revisited--A
Textbook of Classical Homeopathy For the Professional" Luc
DeSchepper, First Edition 2001, "Achieving and Maintaining the
Similimum Strategic Case Management for Successful Homeopathic
Prescribing" Luc DeSchepper, First Edition 2004, "The Organon of
the Medical Art" by Samuel Hahnemann edited by Wenda Brewster
O'Reilly First Edition, 1996.)
[0018] The treatment of most conditions in humans or animals using
conventional methodologies involves the administration of
conventional drug treatments. Such conventional treatments can have
major side-effects to the detriment of many internal organs. These
side-effects, ranging from mild to severe, can prevent their
application to many patients. For example, statins which are used
in the treatment of high cholesterol have many side effects ranging
from mild to severe. These include gastrointestinal symptoms.
Statins can also have severe side effect on the liver and kidney.
Rhabdomyolysis (the pathological breakdown of skeletal muscle) may
lead to acute renal failure when muscle breakdown products damage
the kidney. Thus, with a condition like high cholesterol when it is
being treated by statins, the patient must be continually monitored
to assess whether unrelated systems are being adversely
affected.
[0019] Many other therapies for a wide range of conditions also
result in side effects ranging from mild to potentially lethal side
effects. These side effects and other detrimental effects can also
reduce patient compliance to the drug therapy. For example, many
anti-arthritics and anti-inflammatories have side effects at the
circulatory hepatic or nephrological level. Anti-anxiety drugs
(anxiolytics) can have either a sedative side effect or other often
more hidden behavioural effects can occur, such as dissociation or
there may be a long term inability to cope without the drugs. It
has been recorded that drugs used for the purposes of sedation have
in some cases resulted in the aggravation of symptoms such as
aggression following their use. For example,
acepromazine/acetylpromazine (ACP) is used as a
sedative/tranquilizer by veterinarians. ACP is frequently used in
combination with other sedatives and anaesthetics to provide
smoother sedation ACP can cause side effects, such as effects on
blood pressure. In some cases the lower blood pressure remains long
after the drug has been taken. Due to these side-effects, it may
not be possible to administer ACP to some animals. Anti-pruritic
drugs, which reduce pruritus, or itching, can have side effects
such as drowsiness and lowering blood pressure.
[0020] Therefore, it is desirable to provide a treatment which
addresses these issues and can mitigate at least some of the
significant side-effects and problems associated with conventional
therapies.
[0021] Furthermore, another problem with current conventional
methodologies is that no therapy is 100% effective across a
population no matter what condition is targeted. Any therapy which
can improve effectiveness across a wider range of subjects would be
desirable.
[0022] There is a need for less expensive, safer and more user
friendly therapeutic agents for use in the treatment of a wide
variety of conditions. Hence, the present invention is directed to
specific homeopathic complexes which can treat a wide number of
disorders without the negative side effect and costs issues usually
associated with conventional pharmaceuticals.
[0023] Citation or identification of any document in this
application is not an admission that such document is available as
prior art to the present invention.
SUMMARY OF THE INVENTION
[0024] According to a general aspect of the present invention,
there is provided a homeopathic complex comprises a homeopathic
tincture or dilutions thereof of a silica containing remedy, a
mercury containing remedy, a snake or spider remedy, and a Calcarea
or Sulphur salt or acid.
[0025] According to this general aspect of the invention, the
homeopathic complex comprises a homeopathic tincture or dilutions
thereof of Hepar sulphuris calcareum [Hep] or other similar
profiled Calcarea or Sulphur salt or acids, Lachesis muta [Lach] or
other remedy with a similar profile, Mercurius Solubilis [Merc] or
Similar Mercury based remedy; and Silica [Sil] or other silica
containing compounds.
[0026] According to a further general aspect of the present
invention, there is provided a homeopathic complex as defined
herein for use as an anti-infective agent and/or in the
regeneration of disease or damaged tissue.
[0027] According to a further general aspect of the present
invention, there is provided a method for the treatment or
prophylaxis of infection and/or regeneration of disease or damaged
tissue comprising administering to a subject in need thereof an
effective amount of the homeopathic complex as defined herein.
[0028] Accordingly, it is an object of the invention to not
encompass within the invention any previously known product,
process of making the product, or method of using the product such
that Applicants reserve the right and hereby disclose a disclaimer
of any previously known product, process, or method. It is further
noted that the invention does not intend to encompass within the
scope of the invention any product, process, or making of the
product or method of using the product, which does not meet the
written description and enablement requirements of the USPTO (35
U.S.C. .sctn.112, first paragraph) or the EPO (Article 83 of the
EPC), such that Applicants reserve the right and hereby disclose a
disclaimer of any previously described product, process of making
the product, or method of using the product.
[0029] It is noted that in this disclosure and particularly in the
claims and/or paragraphs, terms such as "comprises", "comprised",
"comprising" and the like can have the meaning attributed to it in
U.S. Patent law; e.g., they can mean "includes", "included",
"including", and the like; and that terms such as "consisting
essentially of" and "consists essentially of" have the meaning
ascribed to them in U.S. Patent law, e.g., they allow for elements
not explicitly recited, but exclude elements that are found in the
prior art or that affect a basic or novel characteristic of the
invention.
[0030] These and other embodiments are disclosed or are obvious
from and encompassed by, the following Detailed Description.
BRIEF DESCRIPTION OF THE DRAWINGS
[0031] The following detailed description, given by way of example,
but not intended to limit the invention solely to the specific
embodiments described, may best be understood in conjunction with
the accompanying drawings, in which:
[0032] FIGS. 1A & 1B show the Feline of Example 2 pre-treatment
and 24 hours later;
[0033] FIGS. 2A & 2B show the "Sambo" Equine Gelding at Day
1/Day 11 of Example 3A prior to treatment (FIG. 2A) and after
treatment (FIG. 2B);
[0034] FIGS. 3A & 3B show the pig of Example 3b prior to
treatment (FIG. 3A) and after treatment (FIG. 3B);
[0035] FIG. 4 show the Cavalier King Charles Female of Example 4
within 24 hours start of treatment;
[0036] FIG. 5 shows the Canine Collie of Example 5;
[0037] FIGS. 6A-6D show the Bichon Frise Male 6 years of Example 6.
The state of the wound is and the repairs due to the cream are
shown in FIG. 6A to 6D. FIG. 6B shows the change at day 12. FIG. 6C
shows the change within 30 days and FIG. 6D shows that within a
year the scar was virtually completely gone and almost the entire
area had normal hair re-growth;
[0038] FIGS. 7A to 7D show the Cat of Example 8;
[0039] FIG. 8 shows the cat of Example 9;
[0040] FIGS. 9A and 9B show the results of the non-nosode
homeopathic treatment on the IgG levels in a group of Lactating
Holstein Cows for Subclinical Mastitis. Based on these results
there is an effect even with out the inclusion of nosodes of
Example 10;
[0041] FIGS. 10A to 10C show the dog of Example 11;
[0042] FIGS. 11A to 11B show the cat of Example 16;
[0043] FIGS. 12A and 12B show the dog of Example 17; and
[0044] FIGS. 13A to 13F show the cat of Example 20.
[0045] FIGS. 14A to 14G show the dog of Example 21.
[0046] FIGS. 15A-E depict the dog of Case Study 1 of Example 22. A.
Wound condition prior to general anaesthesia, 2 weeks post injury.
B. 6 days post second anesthetic procedure and initiating therapy
with HP Vet Cream. C. 6 days, and D. 21 days post second
anaesthetic procedure and initiating therapy with HP Vet Cream. E.
Approximately one year later.
[0047] FIGS. 16A-C depicts the dog of Case Study 2 of Example 22.
A. Clipped lesion on right pinna on day of presentation, B.
Application of HP Vet Cream to the ear. C. 10 days post initial
presentation with substantial healing.
[0048] FIGS. 17A-C depict the dog of Case Study 3 of Example 22. A.
Right inguinal penetrating wound on the day of presentation, B.
Following twice daily application of the homeopathic cream, the
wound showed progressive improvement after B., 2 weeks, and C. 4
weeks of treatment involving only the application of HP Vet
Cream.
[0049] FIGS. 18A-C depict the dog of Case Study 4 of Example 22. A.
Wound on the ventromedial surface of the stifle on the day of
presentation, with evidence of infection. B. The wound at 2 weeks
after initial presentation following a course of
amoxicillin/clavulanic acid and twice daily application of HP Vet
Cream. C. 4 weeks post initial presentation, with the homeopathic
cream the only intervention during the previous 2 weeks.
[0050] FIGS. 19A-C depict the dog of Case Study 5 of Example 22. A.
Photograph of the anesthetized dog's severe dorsal skin wound on
presentation. B. 24 hours post surgical repair and application of
HomeoPet Vet Cream. C. 21 days post surgery D. 1 year post
surgery.
[0051] FIGS. 20A-B depict the animal of Case Study 142 in Example
23.
[0052] FIGS. 21A-B depict the animal of Case Study 143 in Example
23.
[0053] FIG. 22 depicts the animal of Case Study 144 in Example
23.
[0054] FIGS. 23A-C depict the animal of Case Study 145 in Example
23.
[0055] FIGS. 24A-C depict the animal of Case Study 146 in Example
23.
[0056] FIGS. 25A-C depict the animal of Case Study 147 in Example
23.
[0057] FIGS. 26A-C depict the animal of Case Study 148 in Example
23.
[0058] FIGS. 27A-B depict the animal of Case Study 149 in Example
23.
[0059] FIGS. 28A-B depict a patient of Example 24.
[0060] FIGS. 29A-C depict a patient of Example 24.
[0061] FIGS. 30A-E depict a patient of Example 24.
[0062] FIGS. 31A-B depict a patient of Example 25.
[0063] FIGS. 32A-B depict a patient of Example 25.
[0064] FIGS. 33A-B depict a patient of Example 25.
[0065] FIGS. 34A-B depict a patient of Example 25.
[0066] FIGS. 35A-B depict a patient of Example 25.
[0067] FIGS. 36A-B depict a patient of Example 25.
[0068] FIGS. 37A-B depict a patient of Example 25.
[0069] FIGS. 38A-B depict a patient of Example 25.
[0070] FIGS. 39A-B depict a patient of Example 25.
[0071] FIGS. 40A-B depict a patient of Example 25.
[0072] FIGS. 41A-G depict a patient of Example 26.
[0073] FIGS. 41A-C depict a patient of Example 26.
DETAILED DESCRIPTION
[0074] In the specification the term "by weight" refers to the
weight of the final composition and "by volume" refers to the
volume of the final composition.
[0075] In this specification the term "homeopathic tincture and
dilutions thereof" includes a homeopathic mother tincture and/or
its various dilutions or potencies derived from the homeopathic
mother tincture. It will also be understood that the homeopathic
tincture comprises one or more extracts derived from plant,
mineral, animal and/or imponderable substances.
[0076] In the specification, it will be understood that the term
"anti-infective" agent covers both "antimicrobial" or
"antibacterial" effects and covers biocidal or biostatic activity
against various types of organisms including, but not limited to,
bacteria, fungi, viruses, yeasts and/or moulds.
[0077] Finally, in the specification, it will be understood that
the homeopathic ingredients are referred to using different
nomenclature or synonyms. For example, Hepar sulphuris calcareum
can also be referred to as [Hep] or Hepar sulphuris, they all refer
to the same homeopathic ingredient. Furthermore, for some
ingredients, specific species names are given in places and family
names are given in other places. For example, Echinacea is
generally referred to in the description whereas in the examples
the preferred Echinacea plants are mentioned, such as Echinacea
angustifolia [Echi] and Echinacea purpurea [Echi-p]. These comments
are applicable to most ingredients used in the homeopathic
complexes of the invention. The different nomenclature and
family/species for each ingredient is well known in the art and can
be found in the homeopathic literature. The following table
highlights the different names, long names and short names given to
the same homeopathic ingredient.
TABLE-US-00002 Name Of Remedy Abbreviation Alternative
Nomeclature/Synonyms Hepar sulphur hep. Hepar sulphuris calcareum;
(Hep-s); The Calcarea sulphurata Hahnemanni. Also impure Sulphide
of Calcium Lachesis mutus Lach. Lachesis Muta; Bushmaster snake
Lach. Lachesis muta. Bushmaster. Surukuku. Trigonocephalous
lachesis Merc Sol Merc. Mercurius Solubilus; Mercurius Solublis
Hahnemanni; Mercurius Merc-s., Merc., also Metallic Mercury
Quicksilver, Argentum vivum Silica terra Sil. Silica terra Silicea
Terra Silicea Flint. Silex. Silicic anhydride. Silicon dioxide,
Silicia Aconitum napellus Acon. Aconite., Monkshood. Wolfsbane.
Common Aconite. N. O. Ranunculacee. Adrenalinum Adren. Adrenalinum.
Extract of adrenal glands. Sarcode Aesculus hippocastanum Aesc.
Aesculus Horse Chestnut. Aesculus hippocastanum. Hippocastanum
vulgaris. N. O. Sapindaceae Alfalfa Alf Medicago sativa. California
Clover. Lucerne Antimonium tartaricum Ant-t Tartrate of Antimony
and Potash. Tartar Emetic. Antimonium tartaricum Apis mellifica.
Apis. Apis-mel., Honey-Bee. N. O. Insecta. Arnica montana Arn.
Arnica., Leopard's Bane. Brusiewort. Fall Herb. N. O. Composite.
Arsenicum album Ars. Ars Alb., Arsen Alb., Arsencium Alb., Arsenic
Trioxide. The white oxide of metallic Arsenic (Arsenicums)
Arsenicum iodatum Ars-i. Ars Iod., Arsenicum Iod., Iodide of
Arsenic (Arsenicums and Iodatums) Astragalus membranaceus Astra-m
Astragalus membranaceus Astra-m. Astragalus menziesii. N. O.
Leguminose some confusion exists as to whether these are fully the
same from herb to homeopathy Aurum metallicum Aur Aur. Aurum
metallicum. Metallic Gold. Baptisia tinctoria Bapt Baptisia. Wild
Indigo N. O. Leguminosae Baryta carbonica Bar-c. Baryta carb.,
Carbonate of Barium. Bar-c. with which are included symptoms of
Baryta acetica. Belladonna Bell. Atropa belladonna. Deadly
Nightshade. N. O. Solanaceae. Bellis perennis Bell-p. Daisy. N. O.
Composite Berberis Vulgaris Berb Barberry. N. O. Berberidacae.
Bryonia alba Bry. Bryonia. Bryonia dioica. Wild Hops. White Bryony.
N. O. Cucurbitaceae Bufo rana Bufo Bufo., Bufo Satytiensis. N. O.
Bufonide, Batrachide. Toad Poison. Including the common variety,
Bufo rana and the Brazilian toad, Bufo Satytiensis Cactus
grandiflorus cact Cact. Cactus grandiflorus. Cactus Selenicereus.
Night-blooming Cereus. Cereus grandiflorus. N. O. Cactaceae
Caladium seguinum Calad. Calad. Caladium., American Arum. Arum
seguinum. Dumb Cane. N. O. Araceae Calcarea carbonica Calc Calc
Carb.,Calcarea carbonica. Calcarea ostrearum. Conchae Praeparatae.
Impure Calcium Carbonate. Calcarea fluorica Calc-f Calc Fluor.,
Calcarea fluorica. Calcium Fluoride. Fluorspar. Calcarea
phosphorica Calc-p Calc Phos., Calcium phosphate. Calcarea phos.
Phosphate of Lime. Tricalcic Phosphate Calendula officinalis Calen.
Calendula, Pot Marigold. N. O. Composite. Cantharis vesicatoria
Canth. Cantharis., Spanish Fly. Lytta vesicator. N. O. Insecta,
Coleoptera Carbo vegetabilis Carb-v Carbo vegetabilis. Vegetable
Charcoal. Impure carbon Carduus marianus Card-m Carduus mar. St.
Mary's Thistle. Silybum. N. O. Composite Chamomilla Cham.
Chamomilla Matricaria German Chamomile N. O. Composite. Chelidonium
majus. Chel. Chelidonium., Greater Celandine. N. O. Papaveracae.
China officinalis Chin. China., China Regia. Kina-Kina. Peruvian
Bark. Cinchona calisaya aut cinchona succirubra. N. O. Rubiacae
Chionanthus virginica Chion. Fringe-tree bark. Chionanthus
americana. N. O. Oleacee. Cocculus indicus. Cocc. Cocculus., Indian
Cockle. N. O. Menispermacae. Conium maculatum Con. Conium mac.,
Poison Hemlock. N. O. Umbelliferae. Crotalus horridus Crot-h.
Crotalus-h., Crotalus horridus. The Rattlesnake (venom) Crotalidae
Drosera rotundifolia Dros. Drosera. Round-leaved Sundew. N. O.
Droseraceae. Echinacea angustifolia Echi. Purple Cone-flower.
Echinacea angustifolia. Echinacea rudbeckia. N. O. Composite
Echinacea purpurea Echi-p. Black Sampson. N. O. Composite.
Equisetum hyemale Equis. Equisetum., Scouring-rush. Horse-tail
herb. N. O. Equisetaceae Euphrasia officinalis Euphr. Euphrasia.
Eyebright. N. O. Scrofulariaceae Ferrum phosphoricum Ferr-p. Ferric
Phosphate. Ferrum phosphoricum. Ferroso- ferric phosphate. White
Phosphate of Iron, (Schusslers's). Galium aparine Gali. Galium ap.
Goose grass. Cleavers. N. O. Galiacae, Gelsemium sempervirens Gels.
Gelsemium.,Yellow Jasmine. Gelsemium sempervirens. Gelsemium
lucidum. Yellow Jessamine. G. Nitidum. Bignonia sempervirens. N. O.
Loganiacee. Graphites Graph. Graphites naturalis. Black Lead.
Plumbago. Grindelia robusta. Grin. Grindelia squarrosa. Rosin-wood.
N. O. Composite Gunpowder Gunp. Carbon-Sulphur-Kali-Nitricum. Black
Gunpowder Hamamelis virginiana Ham. Hamamelis., Witch-hazel.
Hamamelis macrophylla. Hamamelis dioica. N. O. Hamamelidacee.
Histaminium muriatricum Hist. Imidazolethylamine. Histamine
hydrochloricum Hydrastis canadensis Hydr. Hydrastis., Golden Seal.
The Orange-root. Yellow Puccoon. N. O. Ranunculacee. Hypericum
perforatum Hyper. Hypericum., St. John's-wort. Hypericum
perforatum. N. O. Hypericacee Iodium Iod Iodium purum. Iodine. An
element. Ipecacuanha Ip Ipecac., Ipec root. Cephaelis ipecacuanha.
N. O. Rubiaceae Kalium carbonicum Kali-c Kali Carb., Kali
carbonicum. Carbonate of potassium. Potassium Carbonate Kalium
Iodatum Kali-i Kali Iod., Potassium iodide. Kali hydroiodicum.
Solution. Lac caninum Lac-c Lac can., Dog's milk. Lac vaccinum
defloratum Lac-d. Cow Skimmed Milk. Lac Vaccinum Lac-v Lac
Bovinum., Cows Milk Lappa arctium Lappa. Arctium lappa. Burdock.
Lappa Major. Lappa officinalis. Arcion, (Greek). Gobo. Great Clote
Burre. N. O. Composite. Laurocerasus Laur. Cherry laurel. Cerasus
Laurocerasus. Common Laurel. Prunus Laurocerasus. N. O. Rosacea.
Lavendula vera Lav-v Lavender Ledum palustre Led. Ledum., Marsh
tea. Wild Rosemary. Marsh Cistus. Labrador Tea. N. O. Ericaceae
Lobelia inflata Lob. Indian tobacco, Puke weed. N. O. Lobeliacee.
Lycopodium clavatum Lyc Lycopodium., Club moss. Muscus terrestris
repens. Pes ursinus. Wolf's-claw. N. O. Lycopodiacee Mezereum Mez..
Daphne mezereum. Spurge olive. Chameleons germanica. Mezereon. N.
O. Thymelaceae Millefolium Mill. Millefolium Achillea. Yarrow.
Achillea millefolium. N. O. Composite Natrium muriaticum Nat-m. Nat
mur., Salt, Sodium chloride. Common Rock Salt Nitricum acidum
Nit-ac. Nitric acid. Aqua Fortis. Solution. Nux vomica Nux-v. Nux.,
Poison nut. Strychnos Nux vomica. N. O. Loganiacae. Paeonia
officinalis Paeon. Peony. N. O. Ranunculaceae. Phytolacca decandra
Phyt. Phytolacca., Phytolacca decandra. Poke root. Poke weed.
Virginian Poke. Pole-root. Red Ink Plant. Garget Weed,. N. O.
Phytolaccaceae Phosphorus Phos. The Element Phosphorus --red
amorphous Phosphorus Prednisolone Predn Prednisolone a synthetic
corticosteroid Pulsatilla pratensis Puls. Pulsatilla., Pulsatilla
nigricans. Pulsatilla pratensis. Anemone pratensis. Pasque-flower.
Wind flower. N. O. Ranunculaceae Pyrogenium Pyrog. Pyrogen.,
Pyrogenium. Rotten meat pus., Pyrexin. Sepsin. Ranunculus bulbosus
Ran-b. Ranunculus. Buttercup. Bulbous Crowfoot. N. O. Ranunculacee
Rhus toxicodendron Rhus-t. Rhus Tox., Poison oak. Rhus radicans.
Rhus venenata Rhus-v. Rhus ven., Poison elder. Poison Sumac. Swamp
Sumac. N. O. Anacardiacae Rumex crispus Rumx. Rumex. Yellow dock.
The Curled Dock. N. O. Polygonaceae Ruta Graveolans Ruta. Ruta
graveolens. Garden Rue. Bitterwort. N. O. Rutaceae Sabal serrulata
Sabal Saw palmetto. Serenoa serrulata. N. O. Palmaceae Sepia
officinalis Sep Sepia., Sepia succus. Cuttlefish Ink. Sepia
officinalis. N. O. Cephalopoda. Sol Sol. Sol. Sunlight. Milk sugar
is exposed to concentrated sun's rays and stirred with a glass rod
until saturated. Solidago virgaurea. Solid. Solidago., Goldenrod.
N. O. Compositae, Stannum metallicum. Stann. Stannum Tin.
Trituration of the pure metal Staphisagria Staph. Staphysagria.
Delphinium staphysagria. Stavesacre. N. O. Ranunculaceae Stellaria
media Stel. Chickweed. N. O. Caryophyllaceae Strophantus hispidus
Stroph-h. Strophantus. Kombe seed. Onaye. Onage. Poison of
Pahonias. N. O. Apocynaceae Sulphur Sulph. Sulphur Sublimatum.
Brimstone. Sublimed Sulphur Symphytum officinale Symph. Comfrey.
Knitbone. Symphytum officinale. Healing Herb. N. O. Boraginaceae.
Taraxacum officinale Tarax Taraxacum. Dandelion. Leontodum
taraxacum. N. O. Compositae Tarentula Cubensis Tarent-c. Tarentula
Cub., The Cuban tarentula. Tarentula cubensis. Mygale Cubensis.
Aranea peluda. N. O. Araneideae Tarentula Hispanica Tarent. Spanish
tarentula. Lycosa tarentula. N. O. Araneideae. Thiosinaminum.
Thiosin. Rhodallinum. Mustard seed oil. Allyl sulphocarbamide.
Derived from Oil of Mustard- seed. Rhodallin Thuja occidentalis
Thuj. Thuja., Arbor vitae. N. O. Coniferae Triticum repens Tritic.
Triticum. Couch grass. Agropyrum Repens. Cutch- grass. Quitch
grass. N. O. Gramineae Urtica urens Urt-u. Stinging nettle. Urtica
dioica. The Common Nettle, has similar if not identical properties.
N. O. Urticaceae. Uva ursi Uva. Bearberry. Arctostaphylos. N. O.
Ericaceae. Zincum metallicum Zinc Zincum Met.. Zinc. An Element.
Zn. NOSODES Bacillinum Bac. A Tuberculosis Nosode. Bacillinum. A
maceration made from a tubercular sputum. Corynebacterium Coryne A
Corynebacterium Nosode Tuberculinum Aviairae Tub-a. Avian
tuberculosis - Chicken tuberculosis Tuberculinum Avis Nosodes
Tuberculinum Bovinum Tub Bov Bovine Tuberculosis - Tuberculinum
Bovinum of Kent sometimes same as below Tuberculinum Koch Tub.
Tuberculosis Nosode. The Tuberculinum Bovinum of Kent. Tuberculinum
of Koch. Liquid potencies. Nosode is prepared either from
tubercular abscess or from a glycerine extract of pure cultivation
of human tubercular bacillus. Staph Aureus Nosode Staphycoc
Staphylococcus bacteria. Staphylococcinum. Streptococcus Nosode
Streptoc. Streptococcinum. Streptococcinum bacteria. Medorrhinum
Med. Gonorrhea nosode.. Glinicum. Potencies of the Virus.
Colibacillinum 1 Coli Coliform Nosode Colibacillinum 2 E. Coli
Escherichia coli
[0078] According to a first aspect of the invention, there is
provided a homeopathic complex comprising a homeopathic tincture or
dilutions thereof of
[0079] Hepar sulphuris calcareum [Hep] or other similar profiled
Calcarea or Sulphur salt or acid;
[0080] Lachesis muta [Lach] or other remedy with a similar
profile;
[0081] Mercurius Solubilis [Merc] or similar mercurius based
remedy; and
[0082] Silica [Sil] or other silica containing compounds.
[0083] It will be understood that Hepar sulphuris calcareum [Hep],
Lachesis muta [Lach], Mercurius Solubilis [Merc]; and Silica [Sil]
may be replaced or supplemented with the additional remedies as
outlined below. The main characteristic of the additional remedies
is that they have similar profiles to the remedy they replace or
supplement.
[0084] Furthermore, it will also be understood that these remedies
may be replaced or supplemented with chemical equivalents or
bioequivalents of the homeopathic remedies which essentially mimic
the active moiety within the homeopathic remedy and ideally results
in an agent with a similar profile to the homeopathic remedy. For
example, venoms such as snake or spider remedies may be replaced by
ammonium carbonate. Additionally and by way of non-limiting
examples, the active agent within the Solanacea family (e.g.
Belladonna, Strammonium, Hyoscyamus) are the alkaloids,
particularly the tropane alkaloids, and the active agent within the
Loganiaceae family (e.g. Iganthia, Gelsemium, Nux Vomica) is
strychnine (Strychnos). Other chemical equivalents or
bioequivalents of homeopathic ingredients are well known in the
field.
[0085] According to a specific embodiment, Calc Sulph, Calc Sil or
similar profiled Calcarea or Sulphur or salts or acids thereof may
be present in addition to or instead of Hepar Sulph.
[0086] It will be understood that other similar snake or spider
remedies remedies with a similar septic shock profile to Lachesis
muta can be used. Such remedies include but are not limited to
Crotalidae (crotalus Horridalus), Tarentula Cubensis and/or
Pyrogen.
[0087] Mercurius Solublis can also be known as Hydrargyrum,
Mercurius vivus, Argentum vivum, Mercurius Solublis Hahnemanni,
Metallic Mercury or Quicksilver. It will also be understood that
Mercurius Solubilis may be replaced or complimented with many other
mercury containing compounds. For example, Phytolacca decandra,
also known as Vegetable Mercury, may be used. Phytolacca decandra
has a high Mercury content and similar inimicable relationship to
Mercury as discussed below.
[0088] Silica [Sil] can be known under any of its synonyms, such as
Silica terra, Silicea terra, Flint, Silex, Silica anhydride, Quartz
or Silicon dioxide or may be replaced or complimented with many
other silica containing compounds such as Silica Marina Sea
Sand.
[0089] This homeopathic complex comprising a homeopathic tincture
or dilutions thereof of Hepar sulphuris calcareum or other similar
profiled Calcarea or Sulphur salt or acid; Lachesis muta or other
remedy with a similar profile, such as a spider or snake remedy,
Mercurius Solubilis or other mercurius containing remedy with a
similar profile (such as Phytolacca (vegetable mercury)) and Silica
or other silica containing compounds with a similar profile other
will be referred to as "Core A" within the specification and
examples.
[0090] Essentially, Core A provides a general anti-infective
homeopathic composition for use in the treatment of general
infections and/or sepsis. Core A is essential to all the
homeopathic complexes of the present invention. Essentially, Core A
functions to allow the abortion, resorption, discharge or
absorption of pus formation which develops in association with an
infection and/or sepsis/septic infection.
[0091] Core A also provides for the re-growth and repair of damaged
tissues.
[0092] This specific combination of the four homeopathic
ingredients in Core A provides general anti-infective activity and
is a combination which would not be recommended in most
conventional homeopathic literature due to incompatibility of two
of the ingredients. However, contrary to conventional teachings,
Applicants have found this specific combination is well tolerated
and provides good general anti-infective activity.
[0093] Specifically, according to general homeopathic teachings
Mercurius Solubilis and Silica are incompatible (Remedy
Relationships by Thomas Blasig & Peter Vint 1.sup.st Ed 2001
Published Hahnemann Institut) Silica Terra (Sil) and Mercurius
Solubilis (Merc and Sil) should never be given immediately before
or after each other. They are in homeopathic terms, "inimical" or
incompatible (Nature's Materia Medica, January 2007 (3rd Edition)
(Lotus Materia Medica (1.sup.st & 2.sup.nd Edition) Robin
Murphy) and Concordant Materia Medica (First edition 1994) Frans
Vermeulen)). Based on classical homeopathic teachings, these
ingredients interfere with the action of the other. However,
Applicants have surprisingly found that the homeopathic of the
present invention uses both these homeopathic ingredients together
without any detrimental effect.
[0094] Thus, unexpectedly and contrary to conventional homeopathic
teachings, Core A advantageously provides for the dual
functionality in terms anti-infective activity and re-growth and
repair of damaged tissues of the homeopathic complex of the present
invention. Thus, using this knowledge it was possible to combine
mercury and silica in a way that was beneficial to the patient in
need thereof. This has been used to advantage in a broad way in
Core A.
[0095] Preferably, the homeopathic complex is provided in a potency
range from mother tincture to approximately 100M (MM), preferably
from mother tincture to 50M (CM) and including LM potencies.
[0096] Generally, a "low potency" according to the invention is in
the "X" range and is ideally used for topical administration and
the treatment of chronic conditions. It may also be used internally
to treat the same infection state.
[0097] For such topical use "X" or decimal potencies are most
appropriate due to their suitability for repeated use on a local
area over a period of time, without inducing a homeopathic
aggravation. When this homeopathic complex is made in such low
potencies up to 18.times./9 c, preferably from mother tincture to
approximately 9 c, more preferably from mother tincture to
approximately 18.times. (18.times. and 9 c are roughly equivalent
in terms of dilution) it is ideal for topical use, for example as a
topical anti-infective cream, gel or liquid healing composition.
This comment is applicable to all cores (i.e. Core A and the
following Cores) and all combinations of cores. There are some
exceptions to this rule for example. It will be understood that
some homeopathic ingredients may be administered as a mother
tincture, however, due to Regulatory constraints in some countries,
some homeopathic ingredients may not be administered as a mother
tincture and must be diluted to 2.times., preferably 6.times. or
8.times. or higher for administration. A few non-limiting examples
include Aesculus hippocastanum, Arsenicum Album, Cantharis,
Gelsemium, Mezereum, Nux Vomica, Phosphorus Staphysagria, Nosodes
from the additional Cores C to D would not generally be recommended
for used a Mother Tincture because of Regulatory constraints in
terms of safety below certain potencies. This is explained in more
detail in the various pharmacopeia, for example, the German or
American Homeopathic Pharmacopeia.
[0098] When this formulation is made in "high potencies" according
to the invention, in the C potency range, preferably 30 c plus,
more preferably 200 c plus, it is ideal for internal use, for
example as a liquid for oral or internal administration. Thus, at
these potencies, the homeopathic complex works as an internal
anti-infective healing composition. Again, this comment is
applicable to all cores (i.e. Core A and the following Cores) and
all combinations of cores. In some situations, there are exceptions
to this rule for example, Arsenicum Iod, Hydrastis, Laurocreasus
and Gun Powder (which may be used in addition to Core A) can also
be used in the low potency range even when formulated for internal
administration, as they and other homeopathic ingredients
demonstrate significant effects in low potency.
[0099] Preferably, "high potency" according to the invention is
from about 30 c to about 1M.
[0100] "Very high potency" according to the invention is generally
from about 1M to 10M, and includes LM potencies.
[0101] In the "high" to "very high potency" (C or M potency
dilution), the homeopathic works as an acute anti-infective healing
composition in situations needed a fast-acting response, for
example an anti-infective healing first aid remedy. Thus, when used
internally, it will be understood that a high potency in the C
range to 1M is generally used for the treatment of acute
conditions. The high to very high potencies work best in acute
conditions particularly as a complex for first aid treatment from
such minor injuries as cuts and grazes to such major events as
strokes or traumatic injuries. However, it will also be understood
that the general anti-infective composition or mastitis treatment
composition of the invention can also be used in high potencies for
the internal treatment of infections and/or mastitis.
[0102] When the homeopathic composition of the invention is given
internally at low potencies, generally speaking Core A causes an
abscess to rupture and at high potencies, generally speaking Core A
causes an abscess to be absorbed. Applicants have also found that
at potencies from approximately 9 c to around 30 c, so called
"medium" potencies (between the low and high potencies), that the
homeopathic complex can cause both promote or prevent absorption of
the abscess or promote or prevent rupturing.
[0103] Thus, the potency of the homeopathic ingredients will
generally determine whether it can be applied topically or
internally to achieve the best results. This unexpected "biphasic"
effect of the composition at different potencies, was observed by
the inventors in animals, particularly canines, when the
homeopathic composition was administered. At different potencies
the homeopathic ingredients work in different ways and should be
administered in different ways.
[0104] The homeopathic complex according to the present invention
can be used as an anti-infective agent in the prophylaxis or
treatment of microbial infections.
[0105] When used as an anti-infective agent, the homeopathic
complex can treat most general microbial infections or sepsis.
Advantageously, it has been found that the homeopathic complex
according to the present invention can be used in the treatment of
Methicillin-resistant Staphlococcus aureus (MRSA) or other
associated conditions, including other antibiotic resistant
bacteria or pathogens. In this manner, the homeopathic complex of
the invention can provide the effect of a conventional antibiotic
without the many side effects associated with such conventional
treatments.
[0106] Some non-limiting examples of microbial infections include
external microbial infections of the skin, eyes (including
conjunctivitis), nails, hoof, ears (including otitis) Some
non-limiting examples of microbial infections include internal
microbial infections such as mastitis, pneumonia, metritis, joint
infections; abscesses acute, chronic, resorptive stage; infected,
inflamed or swollen glands.
[0107] Additionally, it has been found that the homeopathic complex
according to the invention also promotes the regeneration of
diseased and/or damaged tissue which includes the re-growth and
repair of damaged tissues and/or cells. When used to promote the
regeneration of diseased and/or damaged tissue the homeopathic
complex can treat multiple conditions. Firstly, the homeopathic
complex can treat a multitude of skin conditions including but not
limited to general infection, inflammation, pyrexia, wound healing,
skin restoration and repair. It can also treat a very wide range of
skin disorders such as eczema, purities, sun damage, wrinkles,
cracked skin, warts, burns such as sun, heat radiation and chemical
burns, piles in humans. Thus, the homeopathic complex can speed the
repair/healing of diseased, damaged, wound or incised tissue
deriving from wounds, cuts, cracks, grazes, bites, ulcers. Such
damaged tissue may be septic, indolent (non-healing), decubitus
(bedsores and pressure damaged skin), recurrent or reopening.
Furthermore, the homeopathic complex may be used in the treatment
of burns including heat, radiation including sun, x-ray treatment
and prevention, chemical and/or friction/work blisters.
Additionally, the homeopathic complex may be used in tissue
regeneration in, for example, grafting such as skin grafting or
fracture repair.
[0108] The homeopathic complex according to the present invention
has many advantageous properties including safety, speed of action,
ease of use and efficacy. These advantages are outlined in the
Example section below.
[0109] The homeopathic complex lacks toxicity and associated side
effects. It is well tolerated and is compatible with many
conventional pharmaceuticals. It provides for a rapid response time
and is highly effective. It can be delivered in multiple formats
from topical to oral to parenteral and there are minimal treatment
requirements which increase patient compliance and enhancing
successful outcomes. Furthermore, it provides for a consistent
response and action across all species and across a wide range of
conditions or even types of the same condition
[0110] It will be understood that Core A provides the general
anti-infective and/or repair/re-growth activity. However, Core A
may be supplemented by the addition of further homeopathic
complexes. There are three other general core groups of homeopathic
complexes which may be added to Core A to provide for additionally
functionality and to improve efficacy. These are homeopathic
complexes which will be known as Core B, Core C and Core D
throughout the specification and examples. The addition of Cores B
to D can increase efficacy and be used to tailor the homeopathic
complex to the specific application needed.
[0111] Core B ingredients are involved in the promotion of tissue
healing.
[0112] Ideally Core B comprises a homeopathic tincture or dilutions
thereof derived from the following ingredients: [0113] the
Ranunculacea family, preferably the Aconite Family or Aconitine,
more preferably Aconite napellus [Acon]; [0114] the Compositae
family, preferably Arnica montana [Arn]; Bellis perennis [Bell-p];
[0115] Calendula Offcinalis [Calen]; Chamomilla Matricaria [Cham];
Millefolium achillea [Mill]; [0116] Carduus Marianus; and/or
Echinacea, preferably Echinacea angustifolia [Echi]; [0117]
Echinacea purpurea [Echi-p]; [0118] the Solanacea family,
preferably Belladonna [Bell]; [0119] Arsenicum, preferably
Arsenicum iodatum [Ars-i] and/or Arsenicum Album; [0120] Bryonia
alba [Bry]; [0121] Hamamelis virginiana [Ham]; [0122] Hypericum
Perforatum [Hyper]; [0123] Ledum palustre [Led]; [0124] Phytolacca
decandra [Phyt]; [0125] The Anacardiacae family preferably Rhus
Toxicodendron [Rhus-T.]; [0126] The Rutaceae family preferably Ruta
Graveolans [Ruta]; [0127] Stellaria media [Stel]; and/or [0128]
Symphytum officinale [Symph].
[0129] According to a preferred embodiment, Core B comprises a
homeopathic tincture or dilutions thereof of the following: [0130]
Aconite napellus; [0131] Arnica montana; [0132] Arsenicum iodatum;
[0133] Belladonna; [0134] Bellis perennis; [0135] Bryonia alba;
[0136] Calendula Officinalis; [0137] Echinacea angustifolia; [0138]
Echinacea purpurea; [0139] Hamamelis virginiana; [0140] Hypericum
Perforatum; [0141] Ledum palustre; [0142] Millefolium achillea;
[0143] Phytolacca decandra; [0144] Rhus Toxicodendron; [0145] Ruta
Graveolans; and/or [0146] Symphytum officinale.
[0147] The combination of the ingredients in Core A and Core B
provides a general anti-infective homeopathic composition for use
in the treatment of general infections/sepsis.
[0148] Optional ingredients which may be included in Core B are
Thuja Occidentalis [Thuj], Chamomilla Matricaria [Cham], Stellaria
media [Stel] and/or the Sulphurs, preferably Sulphur [Sulph]. A
further optional ingredient for Core B is Graphites naturalis
[Graph].
[0149] Additional ingredients which may be added to Core B are
Urtica urens [Urt-u] (equivalent to Urtica dioica), Apis mellifica
[Apis], Umbelliferae preferably Conium maculatum [Con] and/or
Gunpowder [Gunp].
[0150] Core C ingredients function as constitutional modifiers and
work for certain types of individuals boosting their response to
treatment. For example, Calc Carb boosts the health of large boned
heavy often flabby individuals while Phosphorus helps lean thin
high energy outgoing individuals. This is particularly important
when tailoring the treatment to the treatment of groups e.g.
mastitis in a dairy herd will tend toward the lean side while a
beef herd would tend toward the heavy side. The skilled homeopathic
practitioner would be able to determine the appropriate remedies to
administer from the following groups.
[0151] Core C comprises constitutional modifiers preferably
selected from the following homeopathic tincture or dilutions
thereof of: [0152] The Arsenicums, preferably Arsenicum album
[Ars]; [0153] The Barytas and Cabonicums, preferably Baryta
carbonica [Bar-c] and/or Kali Carbonicum; [0154] Carbo vegetabilis
[Carb-v]; [0155] The Calcareas, preferably Calcarea carbonica
[Calc]; Calcarea fluorica [Calc-f] and/or Calcarea phosphorica
[Calc-p]; [0156] Gelsemium sempervirens [Gels]; [0157] Iodium purum
[Iod]; [0158] The Kalis, preferably Kali iodatum [Kali-i] and/or
Kali Carbonicum [0159] Lacs, preferably Lac caninum [Lac-c]; Lac
vaccinum defloratum (skimmed) and/or Lac Vaccinum (cow); [0160]
Lycopodium clavatum[Lyc]; [0161] The Natrums and Muriatricums,
preferably Natrum Mur Nux vomica [Nux-v]; [0162] Phosphorus,
preferably Phosphorus [Phos] and/or Ferrum Phos; [0163] the
Ranunculacea family, preferably Pulsatilla nigricans [Puls] and/or
Staphysagria [Staph]; [0164] Sabal serrulata [Sabal]; [0165] Sepia
succus [Sep]; and/or [0166] Zincums preferably Zincum metallicum
[Zinc].
[0167] Core C may also comprise remedies for severe septic
infection selected from a homeopathic tincture or dilutions thereof
of Baptisia tinctoria [Bapt] and/or Pyrogen [Pyrog].
[0168] Core C may also comprise remedies for blood in milk selected
from a homeopathic tincture or dilutions thereof of Bufo rana
[Bufo] and/or Ipecacuanha [Ip].
[0169] Core C may also comprise a homeopathic tincture or dilutions
thereof of Astragalus membranaceus [Astra-mem].
[0170] Core D functions as anti-puritic/anti-inflammatory
ingredients. When used in combination with any of the other Cores,
this care provides additional anti-puritic/anti-inflammatory
functionality of the homeopathic core. Core D comprises a
homeopathic tincture or dilutions thereof of the following
ingredients: [0171] Adrenalin [Adren]; [0172] Aesculus
hippocastanum [Aesc]; [0173] Alfalfa; [0174] Aurums; [0175] The
Antimoniums, preferably Antimonium Tart Berberis Vulgaris; [0176]
Cactus Grandiflora; [0177] Caladium seguinum [Calad]; [0178]
Cantharis vesicatoria [Canth]; [0179] Carduus Marianus; [0180]
Cocculus indicus [Cocc]; [0181] Chelidonium; [0182] China
officinalis; [0183] Chionanthus virginica; [0184] Drosera
rotundifolia; [0185] Equisetum hyemale; [0186] Euphrasia: [0187]
Galium Aprine; [0188] Grindelia (the Compositae family); [0189]
Histaminium (Histamine) [Hist]; [0190] Hydrastis canadensis [Hydr];
[0191] Lappa Articum (the Compositae family); [0192] Lavender
[Lav-v.]; [0193] Lobelia inflata; [0194] Mezereum [Mez]; [0195]
Nitric acid [Nit-ac]; [0196] Paeonia Officinalis [Paeon]; [0197]
Prednisolone [Predni.]; [0198] Ranunculus bulbosus [Ran-b]; [0199]
Rumex crispus [Rumx]; [0200] Solidago virgaurea; [0201] Strophantus
hispidus (the Compositae family); [0202] Taraxacum officinale (the
Compositae family); [0203] Triticum Repens; [0204] The Stannums
preferably Stannum Met; [0205] Thiosinaminum [Thiosin]; [0206] Uva
Ursi; [0207] Veratrum Album; [0208] Cuprum Met; and/or [0209] Sol
[Sol].
[0210] Advantageously, Cores D when administered with any or all of
Cores A to C can be used as an anti-itch treatment, pile treatment,
stroke treatment, wart treatment, scar treatment, anti-wrinkle
treatment. Core D may act as an anti-pyretic, anti-inflammatory
and/or analgesic. For example, Thiosinaminum [Thiosin] is used to
treat scarring (similar to silica and graphites) and Sol [Sol] is
used to treat sunburn. Many forms of application may be
contemplated. In addition, as with other embodiments of the
invention, the potency can be altered depending on the end use.
[0211] Furthermore, the homeopathic complex of the present
invention, as defined in cores A to D above, may also comprise
nosodes. Nosodes are homeopathic remedies that are made from the
specific products of a particular disease. This can be tissue
containing the actual disease agents or tissue affected by those
agents. Sometimes nosodes are made from vaccines containing the
organisms. The nosodes are prepared in a diluted and potentized
form just like all other homeopathic medicine. There is no
potential for an animal to become infected with a given disease
agent from a nosode because of the pharmaceutical process that
occurs which dilutes and inactivates any viable organisms,
particularly when manufactured using the Hahnemannian method and
they are used at 30 c and above. Nosodes are ideally selected from
Tuberculinum bovinum, Tuberculinium aviaire, Staphylococcus aureus,
Strepococcus, Corynebacterium, E. Coli, Colibacillinum, Bacillinum
and/or Medorrhinum.
[0212] As expanded on above in relation to Core A, an important
aspect of the present invention is the potency of the homeopathic
complex. Specifically, the homeopathic complex may be provided at
different potency levels in order to work in different areas and on
different conditions. Thus, changing the potency, by dilution and
succession, will give a homeopathic complex with a different mode
of action. Thus, a significant advantage of the present invention
is that both the homeopathic ingredients of Cores A to D can be
combined in different ways and the potency can be altered.
Different combinations of Cores and different potencies will result
in a homeopathic complex used for different conditions.
[0213] The invention will now be described in relation to specific
embodiments of the invention and their end uses.
[0214] According to a one specific embodiment of the invention,
there is provided a general anti-infective homeopathic composition
comprising a homeopathic tincture or dilutions thereof of:
[0215] Hepar Sulph, Lachesis, Merc, Sil; and
[0216] Aconite napellus; Arnica montana; Arsenicum iodatum;
Belladonna; Bellis perennis; Bryonia alba; Calenula Offcinalis;
Chamomilla Matricaria; Echinacea angustifolia; Echinacea purpurea;
Graphites naturalis; Hamamelis virginiana; Hypericum Perforatum;
Ledum palustre; Millefolium achillea; Phytolacca decandra; Rhus
Toxicodendron; Ruta Graveolans; Stellaria media; Sulphur; Symphytum
officinale; and Thuja Occidentalis.
[0217] Thus, the general anti-infective healing composition
comprises a homeopathic tincture or dilutions thereof of Core A,
Core B, Graphites, Sulphur, Thuja, Chamomilla and Stellaria.
[0218] Optional ingredients which may be included are Conium
maculatum and/or Gunpowder (depending on Regulatory
constraints).
[0219] Each ingredient is ideally present from 0.1 to 20% v/v based
on the volume of the total composition. Ideally, each ingredient is
present in equal ratios/proportions.
[0220] Ideally, the potency of each ingredient is in the low
potency range from mother tincture to approximately 18.times./9 c,
preferably 12.times./6 c. This potency is ideal for topical
administration, in the form of for example, a topical cream, gel or
liquid. Optionally, this homeopathic composition may be given in a
high potency and used internally as a general anti-infective
healing composition. Applicants have found the best effects are
when the composition is administered in low potency for
administration.
[0221] According to a preferred embodiment, this homeopathic
composition is formulated as a topical cream. A non-active base is
ideally used, comprising lanolin, petroleum and mineral oil. Such
as base could comprise, for example, approximately 15 to 35%,
preferably 25% lanolin, approximately 40 to 60%, preferably 50%
petroleum with 15 to 25%, preferably 25% mineral oil and would be
ideal for use in cold climates. It will be appreciated that any
other non-active bases known may be used.
[0222] The following table outlines suitable potency ranges for
each of the ingredients when used in a topical general
anti-infective healing formulation.
[0223] It will also be understood that some homeopathic ingredients
may be administered as a mother tincture, however, as explained
before, for Regulatory reasons in some countries some homeopathic
ingredients may not be administered as a mother tincture and must
be diluted to 2.times., preferably 6.times. or 8.times. or higher
for administration. These are indicated on the table below.
TABLE-US-00003 Effective [Short Preferred Range for Example Final
dilution Remedy form] Topical Use Potency in Cream Hepar Sulphuris
[Hep-s] Range 2x-12x/6c 3x* 4x Lachesis [Lach] Range 8x-12x/6c 8x
9x Mercurius Solubilis [Merc-s] Range 6x-12x/6c 6x 7x Silica [Sil]
Range 2x-12x/6c 3x* 4x Aconitum Napellus [Acon] Range 2x-12x/6c 3x*
4x Arnica Montana [Arn] Range MT-12x/6c 3x* 4x Arsenicum Iod
[Ars-i] Range 6x-12x/6c 6x 7x Belladonna [Bell] Range 2x-12x/6c 3x*
4x Bellis Perenis [Bell-p] Range MT-12x/6c 3x* 4x Bryonia Alba
[Bry], Range MT-12x/6c 3x* 4x Calenula Offcinalis [Calen] Range
MT-12x/6c 3x* 4x Chamomilla Matricaria [Cham] Range MT-12x/6c 3x*
4x Echinacia augustifolia [Echi-a] Range MT-12x/6c 3x* 4x Echinacia
Purpurea [Echi-p] Range MT-12x/6c 3x* 4x Graphites naturalis
[Graph] Range 8x-12x/6c 8x 9x Hamamellis Virginiana [Ham] Range
MT-12x/6c 3x* 4x Hypericum Perforatum [Hyper] Range MT-12x/6c 3x*
4x Ledum [Led] Range MT-12x/6c 3x* 4x Millefolium [Mill] Range
MT-12x/6c 3x* 4x Phytolacca [Phyt] Range 6x-12x/6c 6x 7x Rhus
Toxicodendron [Rhus-t] Range MT-12x/6c 3x* 4x Ruta Graveolans
[Ruta] Range MT-12x/6c 3x* 4x Stellaria Media [Stel] Range
MT-12x/6c 3x* 4x Sulphur** [Sulph] Range MT-12x/6c 4x 4x Symphytum
[Symph] Range MT-12x/6c 3x* 4x Thuja Occidentalis [Thuja] Range
MT-12x/6c 3x* 4x *these potencies are ideal for use in the USA.
Some minor adjustments to the potencies may be needed for Europe
where for Regulatory reasons 3x potencies require additional tests
and must be 4x or higher for simplified registrations. Again, this
will largely be determined in the country of interest based on
Regulatory constraints. **As stated above, Sulphur for example is
not soluble below 4x but can be mixed into a cream as sulphur
powder that has been titurated with lactose to form a titurate.
Arsenicum Iod, Sulphur, Silica, Graphite and Hepar Sulp are also
insoluble and form titurates not tinctures. Lachesis is best
prepared initially in glycerine (to preserve the protein activity
of the venom) as it can be denatured by both alcohol and
lactose.
[0224] According to this embodiment of the invention, to make an
anti-infective cream, each ingredient is made according to the
potency range above and this is done by different methods depending
on whether it is a tincture or titurate. A titurate refers to the
insoluble homeopathic ingredients, such as Arsenicum Iod, Sulphur,
Silica, Graphite, Hepar Sulp, Lachesis etc, which are diluted and
potentised by grinding with lactose. A tincture is as defined
previously and is diluted and potentised in the usual manner by
succussion in an alcohol and water premix. The tincture and
titurates are then combined with each other and the base cream.
These comments about tincture and titurates are relevant to all
embodiments/compositions of the invention.
[0225] Each ingredient is ideally combined in equal proportions in
a non-active cream base. Ideally, the combined ingredients are
combined with the cream from approximately 1 to 10% w/v based on
the total weight of the final homeopathic composition. Preferably,
the combined ingredients are combined with a cream at from 3 to 6%
w/v based on the total weight of the final homeopathic
composition.
[0226] According to a more specific embodiment of the invention,
there is provided a general anti-infective homeopathic composition
which can be used in the treatment of mastitis.
[0227] Mastitis is initially caused by microbial infection through
damaged skin. In particular, mastitis has a tremendous economic
importance for the dairy industry as the present antibiotic
therapies reduce usable milk yield. Thus, alternative therapies to
conventional antibiotic therapies are under evaluation. Common
causal microorganisms found in mastitis include: [0228]
Staphylococcus aureus; [0229] Staphylococcus albus; [0230]
Streptococcus species e.g. agalactia, uberis, dysgalactia; [0231]
Escherichia coli; [0232] Salmonella species; [0233] Mycobacterium
tuberculosis; and/or [0234] Fungal mastitis e.g. Candida albicans
and Cryptococcus neoformans.
[0235] Such a mastitis treatment ideally comprises a homeopathic
tincture or dilutions thereof of: [0236] Hepar Sulphuris Calcareum,
Lachesis, Merc Sol, Silicea; and [0237] Aconitum Napellus, Arnica
Montana, Arsenicum Iod, Belladonna, Bellis Perenis, Bryonia Alb,
Calenula Offcinalis, Chamomilla Matricaria, Conium maculatum,
Echinacia augustifolia, Echinacia Purpurea, Graphites, Hamamellis
Virginia, Hypericum Perforatum, Ledum, Millefolium, Phytolacca
decandra, Ruta Graveolans, Rhus Toxicodendron, Stellaria Media,
Sulphur, Symphytum, Urtica Urens and Thuja Occidentalis.
[0238] Essentially, this mastitis treatment comprises Core A and
Core B plus Chamomilla Matricaria, Stellaria Media, Graphites,
Sulphur and Thuja, Conium and Urtica.
[0239] Gunpowder is an optional homeopathic ingredient for this
homeopathic composition and its use depends on Regulatory
constraints in the applicable country.
[0240] The homeopathic complex of the present invention may be use
to treat elevated Somatic Cell Counts, to prevent Mastitis and in
the treatment of mammary hypertrophy and other hypertrophic
conditions.
[0241] Again, each ingredient is ideally present from 0.1 to 20%
v/v based on the volume of the total composition. Ideally, each
ingredient is present in equal ratios/proportions.
[0242] Ideally, the potency of each ingredient is in the low
potency range from mother tincture to approximately 18.times./9 c,
preferably 12.times./6 c. This potency is ideal for topical
administration, in the form of for example, a topical cream, gel or
liquid. Optionally, this homeopathic composition may be given in a
high potency and used internally as a mastitis treatment
composition. Applicants have found the best effects are when the
composition is administered in low potency for administration.
[0243] According to a preferred embodiment, this homeopathic
composition is formulated as a topical cream. A non-active base is
ideally used, comprising lanolin, petroleum and mineral oil. Such
as base could comprise, for example, approximately 15 to 35%,
preferably 25% lanolin, approximately 40 to 60%, preferably 50%
petroleum with 15 to 25%, preferably 25% mineral oil and would be
ideal for use in cold climates. It will be appreciated that any
other non-active bases known may be used.
[0244] The following table outlines suitable potency ranges for
each of the ingredients when used in a topical formulation for
mastitis treatment.
TABLE-US-00004 Preferred Potency Effective Final Range for Topical
Preferred dilution in Remedy Use Potency Cream Hepar Sulphuris
2x-12x/6c 3x* 4x Lachesis 8x-12x/6c 8x 9x Mercurius Solubilis
6x-1x/6c 6x 7x Silica[Sil] 2x-1x/6c 3x* 4x Aconitum Napellus
2x-12x/6c 3x* 4x Arnica Montana MT-12x/6c 3x* 4x Arsenicum Iod
6x-12x/6c 6x 7x Belladonna 2x-12x/6c 3x* 4x Bellis Perenis
MT-12x/6c 3x* 4x Bryonia Alb MT-12x/6c 3x* 4x Calenula Offcinalis
MT-12x/6c 3x* 4x Chamomilla Matricaria MT-12x/6c 3x* 4x Conium
maculatum MT-12x/6c 8x 9x Echinacia augstofolia MT-12x/6c 3x* 4x
Echinacia Purpurea 8x-12x/6c 3x* 4x Graphites MT-12x/6c 8x 9x
Gunpowder MT-12x/6c 3x* 4x Hamamellis Virginia MT-12x/6c 3x* 4x
Hypericum Perforatum MT-12x/6c 3x* 4x Ledum 6x-12x/6c 3x* 4x
Millefolium MT-12x/6c 3x* 4x Phytolacca decandra 6x-12x/6c 6x* 7x
Ruta Graveolans MT-12x/6c 3x* 4x Rhus Toxicodendron MT-12x/6c 3x*
4x Stellaria Media MT-12x/6c 3x* 4x Sulphur** MT-12x/6c 3x* 4x
Symphytum MT-12x/6c 3x* 4x Thuja Occidentalis MT-12x/6c 3x* 4x
Urtica Urens MT-200c 30c 30c *these potencies are ideal for use in
the USA. Some minor adjustments to the potencies may be needed for
Europe where for Regulatory reasons 3x potencies require additional
tests and must be 4x or higher for simplified registrations. Again,
this will largely be determined in the country of interest based on
Regulatory constraints. **As stated above, Sulphur for example is
not soluble below 4x but can be mixed into a cream as sulphur
powder that has been titurated with lactose to form a titurate.
Arsenicum Iod, Sulphur, Silica, Graphite and Hepar Sulp are also
insoluble and form titurates not tinctures. Lachesis is best
prepared initially in glycerine (to preserve the protein activity
of the venom) as it can be denatured by both alcohol and
lactose.
[0245] Optionally, nosodes from Tuberculinum bovinum, Tuberculinium
aviaire, Staphylococcus aureus, Strepococcus, Streptococcus uberis
Corynebacterium, E. Coli, Colibacillinum, Bacillinum and/or
Medorrhinum may be used. Ideally, such nosodes are present in a
potency range from 6.times. to 1M, preferably from approximately
6.times.-12.times./6 c. It will be understood that any nosode of
any pathogen or pathological material including those involved in
the condition to be treated may be used.
[0246] A further anti-infective mastitis treatment comprising Core
A; Core B plus Stellaria media, Chamomilla matriaca, Sulphur and
conium; and Core C without Arsenicum album, Gelsemium, Lac vaccinum
and Staphlysagria. Ferrum Phos, Natrum Mur, Kali Carbonicum. This
mastitis treatment was used in Example 10.
TABLE-US-00005 PREFERRD PREFERRED POTENCY PREFERRED CONCENTRATION
CONCENTRATION REMEDY RANGE POTENCY RANGE Vol/Vol % Aconitum
napellus 4x TO12C 6C .1 to 20% 1.15% Aconitum napellus 12c TO 30C
.1 to 20% 1.15% 197c Aconitum napellus 198c TO 200C .1 to 20% 1.15%
10M Apis Mel 6c 6C TO 1M 6C .1 to 20% 0.69% Arnica Montana 6x TO
27C 6C .1 to 20% 0.69% Arnica Montana 27c TO 1M 30C .1 to 20% 0.69%
Astragalus 6x TO 27C 6C .1 to 20% 0.69% Astragalus 27c TO 1M 30C .1
to 20% 0.69% Arsencium Iod 6x to 8x .1 to 20% 0.69% 24x/12c
Baptista 27c TO 1M 30C .1 to 20% 1.15% Belladonna 6c TO 100c 30c .1
to 20% 2.29% Belladonna 101c TO 200c .1 to 20% 2.29% 997C
Belladonna 998C to 1M .1 to 20% 2.29% 9997C Bellis Perenis 6x TO
27C 6C .1 to 20% 1.15% Bellis Perenis 27c TO 1M 30C .1 to 20% 1.15%
Bryonia 4x TO12C 6C .1 to 20% 2.29% Bryonia 12c TO 30C .1 to 20%
2.29% 197c Bryonia 198c TO 200C .1 to 20% 2.29% 10M Bufo 6x TO 27C
6C .1 to 20% 0.69% Bufo 27c TO 1M 30C .1 to 20% 0.69% Calc Carb 6x
TO 27C 6C .1 to 20% 1.15% Calc Carb 27c TO 1M 30C .1 to 20% 1.15%
Calc Phos 6x TO 27C 6C .1 to 20% 1.15% Calc Phos 27c TO 1M 30C .1
to 20% 1.15% Calc Fluor 6x TO 27C 6C .1 to 20% 0.69% Calc Fluor 27c
TO 1M 30C .1 to 20% 0.69% Calendula 6c 6x TO 1M 6C .1 to 20% 0.69%
Carbo Veg 6x TO 27C 6C .1 to 20% 2.29% Carbo Veg 27c TO 1M 30C .1
to 20% 2.29% Chamomilla 6x TO 27C 6C .1 to 20% 0.69% Chamomilla 27c
TO 1M 30C .1 to 20% 0.69% Conium 6x TO 27C 6C .1 to 20% 0.69%
Conium 27c TO 1M 30C .1 to 20% 0.69% Echinacea 6C TO 1M 6C .1 to
20% 0.69% Angustifolia Echinacea purpurea 6C TO 1M 6C .1 to 20%
0.69% Hammamelis 6x TO 1M 30c .1 to 20% 0.69% Hepar Sulph 30C TO
200c .1 to 20% 2.29% 200C Hepar Sulph 201C to 1M .1 to 20% 2.29%
9997C Hepar Sulph 9999C TO 10M .1 to 20% 2.29% 50M Hypericum 6x TO
27C 6C .1 to 20% 0.69% Hypericum 27c TO 1M 30C .1 to 20% 0.69%
Iodium 6x TO 27C 6C .1 to 20% 0.69% Iodium 27c TO 1M 30C .1 to 20%
0.69% Ipecac 6x TO 27C 6C .1 to 20% 0.69% Ipecac 27c TO 1M 30C .1
to 20% 0.69% Kali Iod 6x TO 1M 6C .1 to 20% 0.69% Lac Caninum 6x TO
1M 30c .1 to 20% 2.29% Lac Bovinum 6x TO 1M 30c .1 to 20% 2.29%
Lachesis 6x to 6c .1 to 20% 1.15% 12c/24x Lachesis 12c TO 30c .1 to
20% 1.15% 197c Lachesis 198c TO 200c .1 to 20% 1.15% 10M Ledum 6x
TO 27C 6C .1 to 20% 0.69% Ledum 27c TO 1M 30C .1 to 20% 0.69%
Lycopodium 6x TO 27C 6C .1 to 20% 0.69% Lycopodium 27c TO 1M 30C .1
to 20% 0.69% Merc Sol 30C TO 200c .1 to 20% 1.15% 200C Marc Sol
201C to 1M .1 to 20% 1.15% 9997C Marc Sol 9999C TO 10M .1 to 20%
1.15% 50M Nux Vomica 6x TO 27C 6C .1 to 20% 0.69% Nux Vomica 27c TO
1M 30C .1 to 20% 0.69% Phosphorus 6x TO 1M 30c .1 to 20% 1.15%
Phytolacca decandra 6x to 6c .1 to 20% 2.29% 12c/24x Phytolacca
decandra 12c TO 30c .1 to 20% 2.29% 197c Phytolacca decandra 198c
TO 200c .1 to 20% 2.29% 10M Pulsatilla 6x TO 1M 30c .1 to 20% 1.15%
Pyrogen 30C TO 1M .1 to 20% 1.15% 10M Rhus toxicodendron 6x to 6c
.1 to 20% 0.69% 12c/24x Rhus toxicodendron 12c TO 30c .1 to 20%
0.69% 197c Rhus toxicodendron 198c TO 200c .1 to 20% 0.69% 996c
Rhus toxicodendron 997C TO 1M .1 to 20% 0.69% 9997C Ruta Grav 6x to
6c .1 to 20% 0.69% 12c/24x Ruta Grav 12c TO 30c .1 to 20% 0.69%
197c Ruta Grav 198c TO 200c .1 to 20% 0.69% 10M Sabal 6x TO 27C 6C
.1 to 20% 0.69% Sabal 27c TO 1M 30C .1 to 20% 0.69% Sepia 6x TO 27C
6C .1 to 20% 0.69% Sepia 27c TO 1M 30C .1 to 20% 0.69% Silica 6c TO
100c 30c .1 to 20% 2.29% Silica 101c TO 200c .1 to 20% 2.29% 997C
Silica 998C TO 1M .1 to 20% 2.29% 9997C Stellaria Media 6x TO 1M
30c .1 to 20% 0.69% Suphur 6x TO 1M 30c .1 to 20% 2.29% Symphytum
6x TO 1M 30c .1 to 20% 0.69% Urtica 6x TO 1M 30c .1 to 20% 0.69%
Zincum Met 4x TO12C 4c .1 to 20% 0.69% Zincum Met 6x TO 1M 30c .1
to 20% 0.69% 100.00%
[0247] The composition as defined above is ideal for internal use
and is in the C potency range.
[0248] Ideally, this homeopathic composition is in a form suitable
for internal use, for example a liquid with excipients being
alcohol and water.
[0249] Optionally, nosodes are combined with this homeopathic
mastitis treatment composition. Suitable nosodes are outlined in
the following table.
TABLE-US-00006 PREFERRED POTENCY EXAMPLE CONCENTRATION Vol/Vol NAME
OF REMEDY RANGE POTENCY % RANGE Tuberculinum Bovinum 30C TO 1M 30c
.1% TO 20% Tuberculinium Aviaire 30C TO 1M 30c .1% TO 20%
Staphylococcus Aureus 30C TO 1M 30c .1% TO 20% Strepococcus 30C TO
1M 30c .1% TO 20% Strepococcus Mix 30C TO 1M 30c .1% TO 20%
Corynebacterium 30C TO 1M 30c .1% TO 20% E. Coli (ColibacillinuM)
30C TO 1M 30c .1% TO 20% E. Coli 30C TO 1M 200c .1% TO 20%
Bacillinum 30C TO 1M 30c .1% TO 20% Medorrhinum 30C TO 1M 30c .1%
TO 20%
[0250] Ideally, the nosodes are added in equal
proportions/ratios.
[0251] According to another embodiment of this aspect of the
invention, an effective mastitis treatment comprises the use of the
homeopathic composition defined above for internal use administered
concurrently with the previously defined topical mastitis
treatment.
[0252] According to a more specific embodiment of the invention,
there is provided a general anti-infective homeopathic composition
used in the treatment of trauma or shock comprising a homeopathic
tincture or dilutions thereof of the following ingredients: [0253]
Hepar Sulphuris Calcareum, Lachesis, Merc Sol, Silicea; and
Aconite; [0254] Arsenicum Iod; [0255] Arnica Montana; [0256] Apis;
[0257] Belladonna; [0258] Bellis Perennis; [0259] Bryonia; [0260]
Calendula; [0261] Cantharis; [0262] Carbo Veg;
[0263] Crategus;
[0264] Echinacea Augustifolia; [0265] Echinacea Purpura; [0266]
Ferrum Phos; [0267] Gelsemium; [0268] Hammamellis; [0269]
Hypericum; [0270] Laurocerasus; [0271] Ledum; [0272] Millefolium;
[0273] Nux Vomica; [0274] Phytolacca; [0275] Rhus Tox; [0276] Ruta
Gray; [0277] Symphytum; and [0278] Staphysagria.
[0279] Essentially, this homeopathic composition comprises Core A;
Core B with Chamomilla matricaria and Stellaria media, Sulphur,
Apis and Urtica; Core C ingredients Carbo veg, Gelsemium, Nux
Vomica and Phos; and Cantharis, Laurocerasus, Crategus and Ferrum
phos. The following table outlines suitable potency ranges for each
of the ingredients.
TABLE-US-00007 REMEDY Preferred Range Preferred Potency Aconite
30C-10M 1M Apis 30C-10M 1M Arnica Montana 30C-10M 1M Arsencium Iod
6x to 24x/12c 8x Belladonna 30C-10M 1M Bellis Perennis 30C-10M 1M
Bryonia 30C-10M 1M Calendula 30C-10M 1M Cantharis 30C-10M 1M Carbo
Veg 30C-10M 1M Causticum 28C TO 10M 30c Conium 28C TO 10M 30c
Crategus MT-24x/12c 4x Echinacea Anugustifolia 30C-10M 1M Echinacea
Purpura 30C-10M 1M Ferrum Phos 6x to 24x/12c 12x Gelsemium 30C-10M
1M Hammamellis 30C-10M 1M Hepar Sulph 30C-10M 1M Hypericum 30C-10M
1M Lachesis 30C-10M 1M Laurocerasus MT-24x/12c 4x Ledum 30C-10M 1M
Merc Sol 30C-10M 1M Millefolium 30C-10M 1M Nux Vomica 30C-10M 1M
Phosphorus 30C-10M 200c Phytolacca 30C-10M 1M Rhus Tox 30C-10M 1M
Ruta Grav 30C-10M 1M Silica 30C-10M 1M Sulphur 6x-10m 30c
Staphysagria 30C-10M 1M Symphytum 30C-10M 1M Urtica 28C TO 10M 30c
chamomilla matrica 30-10m 1m stellaria 28c-10m 30c
[0280] Ideally, this homeopathic composition is in a form suitable
for internal use, for example a liquid with excipients being
alcohol and water.
[0281] The homeopathic ingredients are combined from approximately
0.1 to 20% v/v based on the total volume of the final homeopathic
composition. Each ingredient is ideally combined in approximate
equal proportions (1:1 ratio) in the liquid excipient.
[0282] It will be understood that the homeopathic complexes of the
present invention may be used in the both human medical and
veterinary applications and are trans-species in action. Indeed, as
shown in the Examples, the homeopathic complexes work in a wide
variety of species, from companion animal (e.g. canines, felines to
exotic parrot etc) to farm animals (e.g. equines and bovines etc)
and to humans to name a few.
[0283] It will be understood that the general mode of action common
to all the homeopathic complexes of the present invention, is the
treatment of microbial infections and/or the repair and re-growth
of damaged cells or tissue.
[0284] Specific applications of the homeopathic composition
according to the invention, include but are not limited to
treatment of the following conditions: [0285] Wound treatment;
[0286] Fracture treatment; [0287] Dermatitis, including
photo-dermatitis; [0288] Sun burn; [0289] MRSA Infection; [0290]
Mastitis; [0291] Stroke; [0292] Pneumonia; [0293] Hepatitis; [0294]
Nephritis; and/or [0295] Detoxification.
[0296] Some specific non-limiting uses of the homeopathic complex
are outlined as follows.
[0297] The homeopathic complex may be used in the treatment of
various skin conditions including eczema and the like.
Advantageously, Applicants have found that scars are either
prevented or minimized. Thus, the homeopathic complex may be used
as a scar treatment.
[0298] The homeopathic complex may also be used in the treatment of
mastitis, both acute and chronic. Mastitis is a widespread
condition in many animals, in particular cattle. Conventional
treatments for mastitis involve the use of antibiotics which is not
desirable for commercial milk production. Any treatment which
results in the reduction of the use of antibiotics would be
advantageous for commercial milk production in cows. Thus, the
generation of a new therapy for the treatment of mastitis which
does not involve antibiotics is desirable.
[0299] The homeopathic complex may also be used for detoxification
and such a composition would generally comprise Core A and some of
Cores B, C and D.
[0300] According to another aspect of the present invention, the
homeopathic complex can be used as a cosmetic skin preparation. For
example it may be used as an anti-wrinkle cream in the repair and
or regeneration of skin cells.
[0301] Ideally, the homeopathic complex is manufactured according
to a competent homeopathic pharmacopeia such as the German, US, UK,
EU and/or French Homeopathic Pharmacopoeias. Preferably, the
homeopathic complexes are provided in a potency range from 1.times.
to 12.times., more preferably from 3.times. to 12.times. for the
purposes of analytical traceability (Churchill Livingstone's
International Dictionary of Homeopathy Edited by Jeremy Swayne
(2000) page 193, 1st Edition). Although, it will be understood that
any potency from homeopathic tincture upwards can be used provided
that the dangers of toxicity with very low potencies or tinctures
are managed and all Official Regulatory conditions are met.
[0302] Homeopathic complexes are generally prepared in liquid
carrier solutions (as a tincture) but may also be extracted in, for
example, lactose by trituration and may thereafter be prepared in
various delivery forms. For example, the extracted material of the
homeopathic ingredient may be extracted in liquid form, using an
alcohol and water solvent. This is then followed by comminution,
percolation, maceration and squeezing techniques. When extracted in
liquid form the resulting solution can contain anywhere from one
part drug to three parts mother tincture although this strength can
vary from 10 to 50% depending on the monograph used. What makes a
tincture truly homeopathic is the additional dilution process to
where the final tincture represents a dilution of 1:10 of the drug
in effect a 1.times. dilution. Titurates of insoluble homeopathic
ingredients may also be made. Extraction of the homeopathic
ingredient by tituration may take place using lactose to result in
a solid or powder extract done up to 3 c or third centesimal
dilution. The homeopathic tincture or titurate may then be combined
with a base for use as a topical preparation or be used directly as
a liquid oral preparation. Alternatively, it may be sprayed or
impregnated onto various solid mediums, such as a tablet.
[0303] All the complexes according to the present invention may be
used for topical including eye drops, oral, transdermal, implanted,
suppository, or parenteral administration in a wide variety of
forms such as gels, spray, liquids, powders, tablets, pillules,
lotions, liniments, ointments to give just some examples. It will
be understood that the homeopathic complex is made in the usually
homeopathic manner according to homeopathic guidelines. It may then
be administered as it is, or as a homeopathic dilution thereof. It
may be administered in different ways by combining the complex with
a delivery means, such as a cream or spray for topical use or a
tablet for oral administration etc.
[0304] According to one specific embodiment of this aspect of the
invention the homeopathic complex is in the form of an oral
preparation, such as a dry dose form including a powder or tablet.
Preferably, the homeopathic complex is provided in the form of a
dosage unit form selected from a group consisting of tablets,
capsules, pellets, gel caps, pills, pillules, globules, granules,
crystals and suppositories. For example, tablets comprising lactose
and sucrose may be used.
[0305] Alternatively, the homeopathic complex according to this
aspect of the invention may be in the form of a liquid preparation,
such as a syrup or paste, spray or drops. Delivery of the liquid
preparations may be in the form of injections, eyedrops, eardrops,
nasal sprays, inhalers or diffusers.
[0306] According to another embodiment of this aspect of the
invention the homeopathic complex may be in the form of a topical
preparation such as an ointment, cream, lotion, oil, liniment,
liquid and gel, such as a hydrophilic ointment.
[0307] Daily to twice or thrice administration of the homeopathic
complex for a period of days is contemplated. It may be applied
topically as needed, orally for daily dosage in unit dosage form or
in liquid drops.
[0308] Conventional pharmaceutical excipients or cosmetic
excipients suitable for the deliver system used can have the
homeopathic complex incorporated into them or the homeopathic
complex can be applied to the end product or packaged with the end
product.
[0309] Pharmaceutical excipients are substances other than the
pharmacologically active drug or prodrug which are included in the
manufacturing process or are contained in a finished pharmaceutical
product dosage form. They are classified by the functions they
perform in a pharmaceutical dosage form. Principal excipient
classifications or functions include, but are not limited to the
following: [0310] Binders; [0311] Disintegrants; [0312] Fillers
(diluents); [0313] Lubricants; [0314] Glidants (flow enhancers);
[0315] Compression aids; [0316] Colors; [0317] Sweeteners; [0318]
Preservatives; [0319] Suspensing/dispersing agents; [0320] Film
formers/coatings; and/or [0321] Flavors.
[0322] Some, for example, comprise the product's delivery system.
These transport the active drug to the site in the body where the
drug is intended to exert its action. Others will keep the drug
from being released too early in the assimilation process in places
where it could damage tender tissue and create gastric irritation
or stomach upset. Others help the drug to disintegrate into
particles small enough to reach the blood stream more quickly and
still others protect the product's stability so it will be at
maximum effectiveness at time of use. In addition, some excipients
are used to aid the identification of a drug product. Last, but not
least, some excipients are used simply to make the product taste
and look better. This improves patient compliance, especially in
children. Although technically "inactive" from a therapeutic sense,
pharmaceutical excipients are critical and essential components of
a modern drug product. In many products, excipients make up the
bulk of the total dosage form.
[0323] Ideally this formulation is provided in a form suitable for
topical administration. As such, it may be delivered as a topical
cream, lotion, gel, ointment, liniment, eyedrops, spray, skin
patch/dressing or combined with a conventional topical medication
or skin treatment.
[0324] For topical administration, the homeopathic formulation can
be combined into any commercially available base. For examples, the
base may comprise approximately
[0325] Lanolin from approximately 15 to 35%, preferably 25% Mineral
oil from approximately 15 to 35%, preferably 25% Petroleum from
approximately 40 to 60%, preferably 50% at 2 oz/lb.
[0326] Alternatively the base may be a silcox base or a non-lanolin
non-mineral oil aqueous cream.
[0327] In addition, the homeopathic complex may be administered as
a combination therapy, for example, at the same time as a
conventional pharmaceutical, e.g. antibiotic, nutritional
supplement or food.
[0328] In this specification the term "pharmaceutical" or
"pharmaceutical composition" covers any chemical or biological
substance, synthetic or non-synthetic which when taken by a subject
will alter the function of that subject. Such substances ideally
are intended for use in the treatment or prevention of disease in
man or other animals. As such this term encompass more that
conventional drugs or medicines and can also cover food, medicines,
vitamins and minerals in general. Furthermore, the term
"pharmaceutical" also the substance however it is made and, as
such, encompasses biopharmaceuticals, biotechnology-derived
treatments (including gene therapy) and phytotherapies.
[0329] In this specification the term "combination therapy" is used
broadly to cover the simultaneous administration of the homeopathic
complex and the pharmaceutical composition.
[0330] As such, the homeopathic tincture may be packaged separately
to the pharmaceutical composition which is provided with a set of
instructions for co-administration. The term "combination therapy"
also covers the combination of the homeopathic complex with the
pharmaceutical composition as a single entity. In this way, the
homeopathic complex may be combined or integrated with the
pharmaceutical composition during or after manufacture. For
example, the homeopathic complex when in liquid form may be sprayed
onto the pharmaceutical composition. Alternatively, the homeopathic
complex may be provided in liquid or powder form and may simply be
combined or mixed with the pharmaceutical composition during
manufacture. In this manner, the pharmaceutical composition acts as
a delivery system for the homeopathic composition.
[0331] The co-administration of a conventional drug and a
homeopathic according to the invention goes against Classical
Homeopathic teachings and techniques. According to
Classical/conventional homeopathic teachings, homeopathic complexes
must be taken on their own at least 20 minutes after ingesting any
food or drink. On the contrary the present invention dictates that
the homeopathic complex is either part of a combination therapy or
co-administered with a pharmaceutical composition. This would not
be expected in the field of classical homeopathy.
[0332] According to another aspect of the invention, there is
provided a homeopathic complex of the invention for use in
therapy.
[0333] Ideally, the homeopathic complex of the invention is for use
in the treatment or prophylaxis of infection as an anti-infective
agent. Specifically, the homeopathic complex of the invention may
be used in the treatment of mastitis. Specifically, the homeopathic
complex may be used in the treatment or prophylaxis of MRSA and
other type of multi-resistant infections. Additionally, the
homeopathic complex of the invention may be used in the
regeneration of diseased or damaged tissue. In addition, the
homeopathic complex of the invention may be used in the treatment
of skin conditions, including acne, general infection,
inflammation, pyrexia, wound healing, skin restoration and repair
and skin disorders including eczema, puritis, sun damage, wrinkles,
cracked skin warts, burns such as sun, heat and radiation burns
and/or piles. The homeopathic complex of the invention may be used
in the treatment of a stroke or as a first aid remedy.
[0334] According to another aspect of the invention, there is
provided a method for the manufacture of a medicament comprising
the homeopathic complex of the invention for use in the treatment
or prophylaxis of infection and/or the regeneration of diseased or
damaged tissue.
[0335] According to yet another aspect of the present invention
there is provided a method for the treatment or prophylaxis of
infection and/or the regeneration of diseased or damaged tissue in
a subject comprising the steps of administering an effective amount
of a homeopathic complex of the invention claimed to a patient in
need of such treatment.
[0336] The invention will now be described by reference to the
following non-limiting figures and examples.
EXAMPLES
[0337] General Methodology
[0338] The general methodology in the following examples, in
particular in examples 1 to 9, was to select patients where
recovery was not expected despite having been treated with
conventional treatments and there was no other conventional
treatment to use. Thus, patients who received the homeopathic
compositions according to the invention were selected as described
on the basis of a non-response to conventional therapy.
Materials
[0339] Unless otherwise stated, it will be understood that each
homeopathic ingredient is combined in approximate equal proportions
from approximately 0.1% to 20% v/v based on the volume to of the
total homeopathic complex.
[0340] Also unless otherwise stated, homeopathic complexes for
topical use, in the forms of creams, are generally in the low
potency range, from for example mother tincture to approximately
18.times./9 c. For internal use, for example as a liquid
composition, the homeopathic ingredients are generally of the high
potency range from 30 plus, preferably 200 c plus.
[0341] Finally and unless otherwise stated, when used as a cream,
the homeopathic complex is generally combined with a base
comprising approximately 25% Lanolin, approximately 50%
approximately Petroleum with 25% Mineral oil. When used as a liquid
the homeopathic complex is generally administered in alcohol and
water, for example 20% ethyl alcohol and 80% purified water or
30-40% glycerine and 70% purified water. Alternative bases and
carriers, as expanded in the specific Examples following, include
topical antibiotics and Aloe Vera Veterinary spray.
[0342] The following complexes, defined in Cores A to D, were used
in the Examples 1 to 9.
Core A Ingredients
[0343] Hepar sulphuris calcareum [Hep]; Lachesis muta [Lach];
Mercurius Solubilis [Merc] and Silica [Sil].
[0344] These are the essential anti-infective/anti sepsis
ingredients. It will be understood that Lachesis may be replaced or
complemented with many snake or spider remedies which have a
similar septic shock profiles e.g. Crotalidae (crotalus Horridalus)
and Tarentula Cubensis.
Core B Ingredients
[0345] Aconite napellus [Acon]
[0346] Arnica montana [Arn]
[0347] Arsenicum iodatum [Ars-i]
[0348] Belladonna [Bell]
[0349] Bellis perennis [Bell-p]
[0350] Bryonia alba [Bry]
[0351] Calenula Offcinalis [Calen]
[0352] Chamomilla Matricaria [Cham]
[0353] Echinacea angustifolia [Echi]
[0354] Echinacea purpurea [Echi-p]
[0355] Graphites naturalis [Graph]
[0356] Hamamelis virginiana [Ham]
[0357] Hypericum Perforatum [Hyper]
[0358] Ledum palustre [Led]
[0359] Millefolium achillea [Mill]
[0360] Phytolacca decandra [Phyt]
[0361] Rhus Toxicodendron [Rhus-T]
[0362] Ruta Graveolans [Ruta]
[0363] Stellaria media [Stel]
[0364] Sulphur [Sulph]
[0365] Symphytum officinale [Symph]
[0366] Thuja Occidentalis [Thuj]
[0367] Additional Core B ingredients, Conium maculatum [Con] and
Gunpowder [Gunp], were used in Examples 1 to 9 only.
Core C Ingredients
[0368] Arsenicum album [Ars]
[0369] Apis mellifica [Apis]
[0370] Astragalus membranaceus [Astra-mem.]
[0371] Baptisia tinctoria [Bapt]
[0372] Bufo rana [Bufo]
[0373] Carbo vegetabilis [Carb-v]
[0374] Calcarea carbonica [Calc]
[0375] Calcarea fluorica [Calc-f]
[0376] Calcarea phosphorica [Calc-p]
[0377] Gelsemium sempervirens [Gels]
[0378] Iodium purum [Iod]
[0379] Ipecacuanha [Ip]
[0380] Kali iodatum [Kali-i]
[0381] Lac caninum [Lac-c]
[0382] Lac Bovinum Lac Vaccinum (cow)
[0383] Lycopodium clavatum[Lyc]
[0384] Nux vomica [Nux-v]
[0385] Phosphorus [Phos]
[0386] Pulsatilla nigricans [Puls]
[0387] Pyrogen [Pyrog]
[0388] Sabal serrulata [Sabal]
[0389] Sepia succus [Sep]
[0390] Staphysagria [Staph]
[0391] Urtica urens [Urt-u]
[0392] Zincum metallicum [Zinc]
Core D Ingredients
[0393] Adrenalin [Adren]
[0394] Aesculus hippocastanum [Aesc]
[0395] Baryta carbonica [Bar-c]
[0396] Caladium seguinum [Calad]
[0397] Cantharis vesicatoria [Canth]
[0398] Cocculus indicus [Cocc]
[0399] Histaminium (Histamine) [Hist]
[0400] Hydrastis canadensis [Hydr]
[0401] Lavender [Lav-v.]
[0402] Mezereum [Mez]
[0403] Nitric acid [Nit-ac]
[0404] Paeonia Officinalis [Paeon]
[0405] Prednisolone [Predni.]
[0406] Ranunculus bulbosus [Ran-b]
[0407] Rumex crispus [Rumx]
[0408] Thiosinaminum [Thiosin]
[0409] Sol [Sol]
Optional Nosodes
[0410] Nosodes are ideally selected from Tuberculinum bovinum,
Tuberculinium aviaire, Staphylococcus aureus, Strepococcus,
Corynebacterium, E. Coli, Colibacillinum, Bacillinum and/or
Medorrhinum.
The Following Complex was Used in Example 10.
[0411] This treatment essentially comprises, Core A, Core B minus
graphites, millefolium and thuja and Core C minus Arsenicum,
Gelsemium and Staphysagria, plus Conium.
TABLE-US-00008 Preferred Preferred Potency Concentration Actual
Working Potency Of Vol/Vol % Example Name Of Remedy Range Example
Range Vol/Vol % Aconitum napellus 4x TO12C 6C .1% TO 20% 1.15%
Aconitum napellus 12c TO 197c 30C .1% TO 20% 1.15% Aconitum
napellus 198c TO 10M 200C .1% TO 20% 1.15% Apis Mel 6c 6C TO 1M 6C
.1% TO 20% 0.69% Arnica Montana 6x TO 27C 6C .1% TO 20% 0.69%
Arnica Montana 27c TO 1M 30C .1% TO 20% 0.69% Astragalus 6x TO 27C
6C .1% TO 20% 0.69% Astragalus 27c TO 1M 30C .1% TO 20% 0.69%
Arsencium lod 6x to 24x/12c 8x .1% TO 20% 0.69% Baptista 27c TO 1M
30C .1% TO 20% 1.15% Belladonna 6c TO 100c 30c .1% TO 20% 2.29%
Belladonna 101c TO 997C 200c .1% TO 20% 2.29% Belladonna 998C TO 1M
.1% TO 20% 2.29% 9997C Bellis Perenis 6x TO 27C 6C .1% TO 20% 1.15%
Bellis Perenis 27c TO 1M 30C .1% TO 20% 1.15% Bryonia 4x TO12C 6C
.1% TO 20% 2.29% Bryonia 12c TO 197c 30C .1% TO 20% 2.29% Bryonia
198c TO 10M 200C .1% TO 20% 2.29% Bufo 6x TO 27C 6C .1% TO 20%
0.69% Bufo 27c TO 1M 30C .1% TO 20% 0.69% Calc Carb 6x TO 27C 6C
.1% TO 20% 1.15% Calc Carb 27c TO 1M 30C .1% TO 20% 1.15% Calc Phos
6x TO 27C 6C .1% TO 20% 1.15% Calc Phos 27c TO 1M 30C .1% TO 20%
1.15% Calc Fluor 6x TO 27C 6C .1% TO 20% 0.69% Calc Fluor 27c TO 1M
30C .1% TO 20% 0.69% Calendula 6x TO 1M 6C .1% TO 20% 0.69% Carbo
Veg 6x TO 27C 6C .1% TO 20% 2.29% Carbo Veg 27c TO 1M 30C .1% TO
20% 2.29% Chamomilla 6x TO 27C 6C .1% TO 20% 0.69% Chamomilla 27c
TO 1M 30C .1% TO 20% 0.69% Conium 6x TO 27C 6C .1% TO 20% 0.69%
Conium 27c TO 1M 30C .1% TO 20% 0.69% Echinaccea 6C TO 1M 6C .1% TO
20% 0.69% Angustifolia Echinacea 6C TO 1M 6C .1% TO 20% 0.69%
purpurea Hammamelis 6x TO 1M 30c .1% TO 20% 0.69% Hepar Sulph 30C
TO 200C 200c .1% TO 20% 2.29% Hepar Sulph 201C TO 1M .1% TO 20%
2.29% 9997C Hepar Sulph 9999C TO 10M .1% TO 20% 2.29% 50M Hypericum
6x TO 27C 6C .1% TO 20% 0.69% Hypericum 27c TO 1M 30C .1% TO 20%
0.69% Iodium 6x TO 27C 6C .1% TO 20% 0.69% Iodium 27c TO 1M 30C .1%
TO 20% 0.69% Ipecac 6x TO 27C 6C .1% TO 20% 0.69% Ipecac 27c TO 1M
30C .1% TO 20% 0.69% Kali Iod 6x TO 1M 6C .1% TO 20% 0.69% Lac
Caninum 6x TO 1M 30c .1% TO 20% 2.29% Lac Bovinum 6x TO 1M 30c .1%
TO 20% 2.29% Lachesis 6x to 12c/24x 6c .1% TO 20% 1.15% Lachesis
12c TO 197c 30c .1% TO 20% 1.15% Lachesis 198c TO 10M 200c .1% TO
20% 1.15% Ledum 6x TO 27C 6C .1% TO 20% 0.69% Ledum 27c TO 1M 30C
.1% TO 20% 0.69% Lycopodium 6x TO 27C 6C .1% TO 20% 0.69%
Lycopodium 27c TO 1M 30C .1% TO 20% 0.69% Merc Sol 30C TO 200C 200c
.1% TO 20% 1.15% Merc Sol 201C TO 1M .1% TO 20% 1.15% 9997C Merc
Sol 9999C TO 10M .1% TO 20% 1.15% 50M Nux Vomica 6x TO 27C 6C .1%
TO 20% 0.69% Nux Vomica 27c TO 1M 30C .1% TO 20% 0.69% Phosphorus
6x TO 1M 30c .1% TO 20% 1.15% Phytolacca 6x to 12c/24x 6c .1% TO
20% 2.29% decandra Phytolacca 12c TO 197c 30c .1% TO 20% 2.29%
decandra Phytolacca 198c TO 10M 200c .1% TO 20% 2.29% decandra
Pulsatilla 6x TO 1M 30c .1% TO 20% 1.15% Pyrogen 30C TO 10M 1M .1%
TO 20% 1.15% Rhus 6x to 12c/24x 6c .1% TO 20% 0.69% toxicodendron
Rhus 12c TO 197c 30c .1% TO 20% 0.69% toxicodendron Rhus 198c TO
996c 200c .1% TO 20% 0.69% toxicodendron Rhus 997C TO 1M .1% TO 20%
0.69% toxicodendron 9997C Ruta Grav 6x to 12c/24x 6c .1% TO 20%
0.69% Ruta Grav 12c TO 197c 30c .1% TO 20% 0.69% Ruta Grav 198c TO
10M 200c .1% TO 20% 0.69% Sabal 6x TO 27C 6C .1% TO 20% 0.69% Sabal
27c TO 1M 30C .1% TO 20% 0.69% Sepia 6x TO 27C 6C .1% TO 20% 0.69%
Sepia 27c TO 1M 30C .1% TO 20% 0.69% Silica 6c TO 100c 30c .1% TO
20% 2.29% Silica 101c TO 997C 200c .1% TO 20% 2.29% Silica 998C TO
1M .1% TO 20% 2.29% 9997C Stellaria Media 6x TO 1M 30c .1% TO 20%
0.69% Suphur 6x TO 1M 30c .1% TO 20% 2.29% Symphytum 6x TO 1M 30c
.1% TO 20% 0.69% Urtica 6x TO 1M 30c .1% TO 20% 0.69% Zincum Met 4x
TO12C 4c .1% TO 20% 0.69% Zincum Met 6x TO 1M 30c .1% TO 20% 0.69%
100.00%
[0412] The following optional nosodes may also be added, at a
preferred potency of 30 C to 1M and a 1:1 ratio of each ingredient:
Tuberculinum Bovinum, Tuberculinium Aviaire, Staphylococcus Aureus,
Strepococcus, Strepococcus Mix, Corynebacterium, E. Coli
(Colibacillinum), Bacillinum and Medorrhinum at a preferred potency
of 30 C. E. Coli was added at a preferred potency of 200 C.
[0413] The following homeopathic complexes were used in Examples 11
to 20.
Vet Cream
[0414] This treatment essentially comprises, Core A and Core B with
graphites, sulphur and thuja (the optional Core B ingredients).
[0415] Each homeopathic ingredient was combined in approximate
equal proportions based on the volume to of the total homeopathic
complex and administered as a cream with a base comprising
approximately 25% Lanolin, approximately 50% approximately
Petroleum with 25% Mineral oil.
TABLE-US-00009 [Short Preferred Remedy form] Range for Topical Use
Potency Hepar Sulphuris [Hep-s] Range 2x-12x/6c 3x Lachesis [Lach]
Range 8x-12x/6c 8x Mercurius Solubilis [Merc-s] Range 6x-12x/6c 6x
Silica [Sil] Range 2x-12x/6c 3x Aconitum Napellus [Acon] Range
2x-12x/6c 3x Arnica Montana [Arn] Range MT-12x/6c 3x Arsenicum Iod
[Ars-i] Range 6x-12x/6c 6x Belladonna [Bell] Range 2x-12x/6c 3x
Bellis Perenis [Bell-p] Range MT-12x/6c 3x Bryonia Alba [Bry],
Range MT-12x/6c 3x Calenula Offcinalis [Calen] Range MT-12x/6c 3x
Chamomilla Matricaria [Cham] Range MT-12x/6c 3x Echinacia
augustifolia [Echi-a] Range MT-12x/6c 3x Echinacia Purpurea
[Echi-p] Range MT-12x/6c 3x Graphites naturalis [Graph] Range
8x-12x/6c 8x Hamamellis Virginiana [Ham] Range MT-12x/6c 3x
Hypericum Perforatum [Hyper] Range MT-12x/6c 3x Ledum [Led] Range
MT-12x/6c 3x Millefolium [Mill] Range MT-12x/6c 3x Phytolacca
[Phyt] Range 6x-12x/6c 6x Rhus Toxicodendron [Rhus-t] Range
MT-12x/6c 3x Ruta Graveolans [Ruta] Range MT-12x/6c 3x Stellaria
Media [Stel] Range MT-12x/6c 3x Sulphur [Sulph] Range MT-12x/6c 4x
Symphytum [Symph] Range MT-12x/6c 3x Thuja Occidentalis [Thuja]
Range MT-12x/6c 3x
Mastitis Treatment
[0416] This treatment essentially comprises, Core A and Core B with
optional ingredients thuja, sulphur and graphites and additional
ingredients Urtica, Gunpowder and Conium. The addition of Gunpowder
is optional and depends on Regulatory Rules.
[0417] Each homeopathic ingredient was combined in approximate
equal proportions based on the volume to of the total homeopathic
complex and administered as a cream with a base comprising
approximately 25% Lanolin, approximately 50% approximately
Petroleum with 25% Mineral oil.
TABLE-US-00010 Preferred Potency Range for Effective Final Topical
Preferred dilution in Remedy Use Potency Cream Hepar Sulphuris
2x-12x/6c 3x 4x Lachesis 8x-12x/6c 8x 9x Mercurius Solubilis
6x-1x/6c 6x 7x Silica[Sil] 2x-1x/6c 3x 4x Aconitum Napellus
2x-12x/6c 3x 4x Arnica Montana MT-12x/6c 3x 4x Arsenicum Iod
6x-12x/6c 6x 7x Belladonna 2x-12x/6c 3x 4x Bellis Perenis MT-12x/6c
3x 4x Bryonia Alb MT-12x/6c 3x 4x Calenula Offcinalis MT-12x/6c 3x
4x Chamomilla Matricaria MT-12x/6c 3x 4x Conium maculatum MT-12x/6c
8x 9x Echinacia augstofolia MT-12x/6c 3x 4x Echinacia Purpurea
8x-12x/6c 3x 4x Graphites MT-12x/6c 8x 9x Gunpowder MT-12x/6c 3x 4x
Hamamellis Virginia MT-12x/6c 3x 4x Hypericum Perforatum MT-12x/6c
3x 4x Ledum 6x-12x/6c 3x 4x Millefolium MT-12x/6c 3x 4x Phytolacca
decandra 6x-12x/6c 6x 7x Ruta Graveolans MT-12x/6c 3x 4x Rhus
Toxicodendron MT-12x/6c 3x 4x Stellaria Media MT-12x/6c 3x 4x
Sulphur MT-12x/6c 3x 4x Symphytum MT-12x/6c 3x 4x Thuja
Occidentalis MT-12x/6c 3x 4x Urtica Urens MT-200c 30c 30c
Trauma/First Aid Treatment
[0418] Each homeopathic ingredient below was combined in
approximate equal proportions based on the volume to of the total
homeopathic complex and administered as a liquid in alcohol and
water, for example 20% ethyl alcohol and 80% purified water.
TABLE-US-00011 Preferred Effective Final Potency Range Preferred
dilution in Remedy for Topical Use Potency Cream Hepar Sulphuris
2x-12x/6c 3x 3x Lachesis 8x-12x/6c 8x 9x Mercurius Solubilis
6x-1x/6c 6x 7x Silica[Sil] 2x-1x/6c 3x 4x Aconitum Napellus
2x-12x/6c 3x 4x Arnica Montana MT-12x/6c 3x 4x Arsenicum Iod
6x-12x/6c 6x 7x Belladonna 2x-12x/6c 3x 4x Bellis Perenis MT-12x/6c
3x 4x Bryonia Alb MT-12x/6c 3x 4x Calenula Offcinalis MT-12x/6c 3x
4x Chamomilla Matricaria MT-12x/6c 3x 4x Conium maculatum MT-12x/6c
8x 9x Echinacia augstofolia MT-12x/6c 3x 4x Echinacia Purpurea
8x-12x/6c 3x 4x Graphites MT-12x/6c 8x 9x Gunpowder MT-12x/6c 3x 4x
Hamamellis Virginia MT-12x/6c 3x 4x Hypericum Perforatum MT-12x/6c
3x 4x Ledum 6x-12x/6c 3x 4x Millefolium MT-12x/6c 3x 4x Phytolacca
decandra 6x-12x/6c 6x 7x Ruta Graveolans MT-12x/6c 3x 4x Rhus
Toxicodendron MT-12x/6c 3x 4x Stellaria Media MT-12x/6c 3x 4x
Sulphur MT-12x/6c 3x 4x Symphytum MT-12x/6c 3x 4x Thuja
Occidentalis MT-12x/6c 3x 4x Urtica Urens MT-200c 30c 30c
Example 1
[0419] Subject--Springer Spaniel Female neutered, age 5 years old
on Day 0.
Condition/Symptoms of Subject
[0420] The patient presented with non-healing wound of what
appeared to be a MRSA-type infection resulting from minor surgical
wound as a result of elective surgery in the area of the stopper
pad. The owner described the original wound as having been
completely closed after surgery. [0421] The patient had an
ulcerative skin lesion which had started after minor surgery and
had gradually extended. [0422] There had been no response to
repeatedly changed conventional antibiotics (Fuciderm.RTM.) or the
antibiotic impregnated dressings used [0423] After using a number
of conventional antibacterial therapeutics the owner had decided to
try an alternative approach.
Treatment
[0424] On Day 0 the patient was taken off all oral conventional
medication. A cream consisting of Core A and Core B with the
addition Fucidin was applied by mixing a tube of Topical Ophthalmic
Antibiotic FUCITHALMIC.RTM. Viscous Eye props (1% fusidic acid).
The Cream was applied to the affected area generously and the area
bandaged up with cotton wool and an elastic self adhesive bandage
and covered with an elastic adhesive bandage. Four days later, a
very substantial improvement in the patient's condition was
observed. Treatment with just a cream consisting of core A and core
B was then repeated without the addition of the Fucidin. The
patient was next seen in 5 months later and the treatment had been
successful.
Conclusion
[0425] The dramatic and unexpected response in this subject
confirms what has been seen in many other patients that the
homeopathic complex of the invention work. There are no reported
side effects, toxicity, administration was easy and the
effectiveness in this species was dramatic and successful.
[0426] The homeopathic complex of the invention comprising Core A
and Core B work when co-administered with conventional
therapeutics, when the conventional therapeutic (antibiotic) did
not work on its own. It shows the synergy with conventional therapy
with no negative interaction
[0427] This example also indicates that the homeopathic complex of
the invention is capable of saving lives as in the case of this
subject where it was non-responsive before treatment, with the
potential of having a limb amputated if the condition had continued
to progress as it had been, not only did it save the subject from
an amputation with possible similar consequences, but it restored
the limb to full normality completely healing the ulcers
Example 2
[0428] Subject--Feline male neutered of indeterminate age
Conditions/Symptoms of Subject
[0429] The subject originally presented as a post road traffic
accident patient, with multiple traumatic skin injuries and
multiple fractures of the left femur the latter were repaired by
open reduction and intramedullary pining. The fracture site had to
be partially re-broken as there was already cartilaginous callus
repair with very mal-aligned bone fragments.
[0430] The subject was post shock. It was already in the healing
phase of injury, but the wounds were still open and fresh. The bone
fractures were attempting to heal out of alignment. The subject was
initially unable to walk on the hind legs despite having one
un-fractured leg. The musculature bones and wounds were all
painful. The wounds were due to grazing probably from contact with
a road surface and so friction burns as well as wounds, bruising
and fractures were present.
Treatment
[0431] The fractures were treated by open reduction. Immediately
post surgery the patient was administered a 0.21 ml liquid dropper
dose of a complex of Cores A, B and C combined in an excipient of
20% ethyl alcohol and 80% purified water. This was given on a first
aid basis to aid recovery and promote rapid healing. Subsequently,
a cream comprising Core A and B for topical application in a base
carrier of 25% Lanolin and 50% white petroleum at 2 oz/lb and 25%
mineral oil with the homeopathic combination added at 3.33% Vol/Vol
(3.33 ml/100 ml) w/w (3.33 g/100 g) was applied topically to all
wounds and known bruised regions including the surgical wound
particularly over the fracture site. Antibiotic cover was provided
by Crystapen into the surgical wound and parental Amoxycillin and
Clavulanic Acid (Synulox Pfizer), but would not explain the
rapidity of recovery other than the absence of infection.
Result
[0432] FIG. 1a shows the subject of Example 2 pre-treatment and
FIG. 1b shows the subject of Example 2 after a 24 hour of
treatment.
[0433] The results were dramatic with the patient walking to obtain
food within 48 hours of the surgery. Not only that but as pictures
FIG. 1a and FIG. 1b show the rate at which healing progressed in
this patient with the gap between photographs of the same wound
being of the order of 24 hours. All wounds had completely resolved
in a 10 day period.
Conclusion
[0434] This case shows the unexpected rapidity of wound, fracture
and injury resolution brought about by the use of the Cream with
Core A and B combined topically and the oral administration of just
a single unrepeated dose of Core A, B and C in a liquid dose
form.
[0435] It once again shows the synergy with conventional therapy
with no negative interaction. Once again there were no reported
side effects, toxicity, administration was easy and the
effectiveness in a different species to Example 1 was just as
dramatic and successful
Example 3(A)
[0436] Subject--"Sambo" Equine Gelding 14-16 years old
Conditions/Symptoms of Subject
[0437] Subjects, "Sambo" Equine Gelding 14-16 years old and a
piebald mare, presented with acute severe photo-dermatitis due to
sun over-exposure. [0438] All the un-pigmented skin on the nose was
suffering from severe solar radiation burns (FIG. 2a) [0439] The
skin on the nose was sunburnt, oozing, scabby, cracked, and painful
to movement and touch. There were also patches of sloughing.
Treatment
[0440] A cream comprising Core A and B for topical application in a
base carrier of 25% Lanolin and 50% White Petroleum at 2 oz/lb and
25% mineral oil with the homeopathic combination added at 3.33%
(3.33 ml/100 ml) was applied topically on a twice daily basis for 5
days to the affected areas of the subject and then once daily due
to the rapidity of improvement.
Results
[0441] FIG. 2a was taken on day one with FIG. 2b taken 11 days
later. The homeopathic complex used promoted rapid healing and also
conferred some form of resistance to further sunburn or sun
sensitivity
[0442] This protocol has been repeated with other horses with
exactly similar results. In one patient so severe was the reaction
that the glands on the neck swelled up in acute response. The
affected area was so sore cream could only be applied around the
affected area. However, a similar response was achieved.
Conclusion
[0443] Previous cases of equine photo-dermatitis had taken between
3 months in mild cases, to 6 months in similarly severe cases to
recover and then in many cases residual scarring was present. This
case shows the unexpected rapidity of burn resolution brought about
by the use of a topical cream with Core A and B.
Example 3(b)
[0444] Subject--Herd of male and female pigs less than 1 year of
age
Conditions/Symptoms of Subject
[0445] Subjects were presented with acute severe photo-dermatitis
after being left out on new pasture during a period of unbroken
sunshine. The subjects presented much as a case of bad human
sunburn would (FIG. 3a) with the whole patient having a bright red
burning hot inflamed tender skin with crusting of the skin at the
worst affected areas where there was deep cracking due to third
degree burning. There were areas of peeling and scabbing of the
affected skin.
Treatment
[0446] Due to success with previous cases in a range of other
species a treatment with Core A and Core B combined was used.
However, due to the number of animals a novel delivery method was
required. Aloe Vera Veterinary Spray (Forever Living Products) was
used as a carrier for Core A and Core B. Once daily spraying of the
carrier with Core A and Core B was decided upon with a second spray
when possible at feeding time.
Result
[0447] A complete and total resolution of all the symptoms of
severe sunburn leaving normal healed skin was achieved in 10 days
and this change is shown in FIG. 3b. The skin is normal pink and
healthy with no signs that would normally be expected with this
degree of sunburn having been present 10 days earlier. This similar
to Example 3a the improvement and healing was achieved in a very
short time period.
Conclusion
[0448] This case shows yet again the unexpected rapidity of burn
resolution brought about by the use of the Cream with Core and Core
B combined topically. In addition, it demonstrates both the healing
properties of the invention and the anti-sepsis properties of the
Cores (none of the burns in the group became infected despite the
muck, dirt and flies that were present). Additionally, the
homeopathic complex minimized scarring. Furthermore, the
homeopathic complex may be used with groups, herd, flocks etc.
Example 4
[0449] Subject--Cavalier King Charles Female--not neutered age 3%
years old.
Conditions/Symptoms of Subject
[0450] Patient presented with acute mastitis. Initial examination
showed the patient to have a temperature in excess of 104.degree.
F./40.degree. C. The mammary glands were hard swollen and in danger
of gangrene on assessment. The patient was treated with a combined
homeopathic and conventional therapy.
Treatment
[0451] As the condition was acute severe and life threatening, it
was decided to treat with a combination of homeopathic and
conventional therapy.
[0452] An initial injection of Synulox.RTM. (Amoxycillin Trihyd,
Clavulanic Acid) at a dose of 1 ml SC and Clamoxyl LA.RTM.
(Amoxycillin Trihyd) at a dose of 2 ml SC and an oral dose of 15
drops of Cores A, B and C with nosodes at dose of 0.07 ml/drop
which was approximately 1 ml liquid dropper dose of complex of
Cores A, B and C combined in an excipient of 20% ethyl alcohol and
80% purified water to act as an anti-infective was administered as
a single initial dose. Topical application of a cream comprising
Core A and B for topical application in a base carrier of 25%
Lanolin and 50% white Petroleum at 2 oz/lb and 25% Mineral oil with
the homeopathic combination added at 3.33% (3.33 ml/100 ml) was
also carried out. The patient was checked the following day and the
mammary glands as evidenced in the picture below had virtually
returned to normal. The owner was told to complete the antibiotic
course to prevent any resistance developing.
Results and Conclusion
[0453] The owner reported that by the time the dog got home some 15
minutes after being given the Cores A, B and C orally as a liquid
preparation and having topically applied a cream with Cores A and B
the subject had already started to improve.
[0454] FIG. 4 shows the subject within 24 hours of the start of
treatment. The patient was checked the following day and the
mammary glands had virtually returned to normal within a 24 hour
period. The owner was told to complete the antibiotic course to
prevent any resistance developing.
Conclusion
[0455] This example demonstrates the synergy of the homeopathic
complex of the invention and correctly chosen conventional
pharmacotherapy, an antibiotic in this case. It demonstrates the
speed of action of this invention as some 15 minutes after
initiation of therapy there had been an improvement and within 24
hours there appeared to be almost complete resolution of the
mastitis, which was severe and septic in nature. It demonstrates
that this medication is capable of speeding the resolution of a
very severe case of acute sepsis in conjunction with conventional
therapy.
Example 5
Subject--Canine Collie Cross Male 1 Year old
Conditions/Symptoms of Subject
[0456] Subject presented with several skin reaction (around nose
area) to hogweed or other related plants (FIG. 5(a) before (b)
after). [0457] The skin had vesicles which were intensely itchy and
were oozing serum as a result of intense puritus.
Treatment
[0458] Twice daily topical treatment with cores A and B and oral
treatment with modulator Ranunculus Bulbosa, Sol 30 c from core
D.
[0459] Core A and B were administered as a cream in a buffered
cream base carrier of Purified water BP, Soft White Paraffin BP,
Dehydag Wax, Liquid Paraffin BP, DiSodium Hydrogen Phosphate BP
Citric Acid BP and Chlorocresol BP for Core D modulators added at
3.33% and combined and 50% White Petroleum at 2 oz/lb and 25%
Mineral oil with the homeopathic combination added at 3.33% (3.33
ml/100 ml). Rhus Tox and Urtica Urens 6 c were also administered
with Core A and Core B.
Result
[0460] Condition disappeared after homeopathic complex
administration
Conclusion
[0461] This example demonstrates the antipuritic and
anti-inflammatory as well as the wound resolution capabilities of
the homeopathic complex. Both plant chemical burns and auto-immune
conditions are generally very difficult to resolve even over a
prolonged period often leaving severe scarring or a constantly
recurrent condition. The resolution of this case alone was
unexpected without having a protracted treatment period with
considerable scaring.
[0462] This example also demonstrates the speed, efficacy, safety
(as dogs continually lick off the cream in this location) and ease
of use where the condition was painful and puritic and yet was
alleviated on administration of the cream.
Example 6
Wound Healing Case Study--Wound Closure of a Chronically Infected
Non Healing Wound
[0463] Subject--Bichon male neutered 6 years old.
Conditions/Symptoms of Subject
[0464] The subject presented with severe damage to tissues of the
leg where there were areas of necrotic tissue that sloughed leaving
even more exposed areas. The patient presented with a suspected
hairline fracture of a digit. The leg was severely wounded and was
bandaged.
[0465] The patient was already on antibiotic therapy and there was
antibiotic dressing on the wounds. The owner sought a second
opinion on the basis that the wound smelled strongly offensive, the
patient was much more tender and lame on the affected leg. FIG. 6a
gives a very accurate idea of the condition the leg was in when the
dressing was removed initially, although the picture was taken
after ten days of treatment following the initial second opinion
consultation
Treatment
[0466] Initial treatment was with antibiotics Synulox.RTM. 250 mg
composition (200 mg amoxicillin and 50 mg clavulanic acid) was
given orally at a dose of 1/2 tablet twice daily for 7 days along
with Metronidazole 200 mg 1/2 tablet twice daily for 7 days. The
wound was left open. At this point due to lack of progress the
antibiotic was changed to Lincocin (Antirobe 50 mg) 1 tablet twice
daily. Calendula 6 c was given orally three times daily to try
promote healing. Although the wound no longer smelled, its healing
had failed to progress at all.
[0467] It was decided at this point to abandon systemic antibiotic
therapy to treat the wound. The patient was anaesthetised using
ACP2 mg/ml as a premed 0.05 ml IM, Thiopentone 2.5% IV as a
knockdown anaesthetic and maintained on Isoflourane. A swab was
taken for culture at this point despite antibiotic therapy, as it
was hoped that it might give some indication of a suitable
treatment. The area around the wound was clipped and tension
sutures placed in the wound which failed to provide reasonable
apposition but did reduce some of the wound size. The wound was
once again washed with Hibiscrub Surgical Wash, followed by
povodine Iodine surgical scrub and then rinsed with saline and then
bathed in sterile water with Homeopathic Mother tincture of
Calendula (Marigold) at a dilution of 20 drops of mother tincture
add to 100 ml of sterile water. The wound was then allowed to dry
fully and a cream comprising Core A and B for topical application
in a base carrier of 25% Lanolin and 50% White Petroleum at 2 oz/lb
and 25% Mineral oil with the homeopathic combination added at 3.33%
(3.33 ml/100 ml). The cream was to be applied to the open wound 2
to 3 times daily. All antibiotic therapy was discontinued. The most
open upper part of the wound had tension sutures placed in it to
draw the edges somewhat closer together. This was to be followed by
the application of the cream as described as the wound still
remained very open.
[0468] Within 10 days as in the previous examples a huge amount of
healing had taken place with the photograph FIG. 6b showing the
change at day 12. Within 30 days the wound was completely healed
and only a thin scar remained (FIG. 6c) and within a year the scar
was virtually completely gone and almost the entire area had normal
hair re-growth (FIG. 6d)
Result
[0469] 20 days after the initial injury and just 7 days after
starting treatment the healing results were amazing the odour was
completely gone the skin and wound showed a dramatic healing even
in the area where the skin was black and hard it had gone soft and
pink.
[0470] Three weeks later, the wound is fully closed, clean with
hair re-growth.
Conclusion
[0471] The homeopathic complex when applied to this wound acted as
an anti-infective as antibiotic therapy was terminated when therapy
with the cream comprising Core A and B was initiated in addition to
this the rate of wound healing and resolution was dramatically
accelerated as shown in FIGS. 6(a-d). The end result was an almost
total return to normal of the affected area, a dramatic result by
any standards.
[0472] This example demonstrates the true extent of action of Core
A and B when used on their own in a cream delivery system to a
wound with indolent healing features as in this case where after
over 10 days there was no sign of granulation or healing in the
wound yet with the introduction of the invention the wound which
was large and non healing suddenly started to show accelerated
healing.
[0473] It also demonstrated that this invention acts with similar
efficacy across many different types of wound and skin condition a
very unique feature. It demonstrates the usefulness of the
invention with septic wounds and particularly those with antibiotic
resistant infections (Multi-resistant Infections) as in this wound
a range of antibiotics had been used with no resolution of the
wound. The prolonged nature of the treatment also demonstrated the
safety and lack of toxicity or side effects of the invention as the
owner continued to apply the cream sparingly to the affected area
for months till almost any signs of scarring let alone the wound
had resolved. It also shows how well tolerated the invention is in
this format--despite how painful, raw and sensitive the area was
the owner was able to apply the invention several times a day.
Example 7(A)
[0474] Subject--Human 31 year old Lactating female.
Conditions/Symptoms of Subject
[0475] The subject a 31 year old female developed a complaint of
sore swollen painful breasts associated with the breast feeding of
her second child. [0476] The symptoms began to appear within 10
days of leaving the hospital post birthing. [0477] The glands were
swollen and painful to the touch, the breasts were engorged with
milk and the patient complained that breast feeding was difficult
at best. There had been no previous history of any mammary gland
infection with the pervious child birth. A diagnosis of post
birthing mastitis was given and a course of antibiotics were
prescribed by the treating physician. After several days the
patient still had no relief and began to seek alternative
options.
Treatment
[0478] The patient began treatment with oral dosing of the
homeopathic medication complex for mastitis comprising Cores A, B
and C (no nosodes) in dropper dose in an excipient of 20% ethyl
alcohol and 80% purified water twice daily with the product being
sprayed onto the oral mucosa 13 days post birthing.
Result
[0479] Relief was established within 24 hours and a total
elimination of symptoms in 48 hours. There has been no
re-occurrence of the condition or symptoms since treatment
Example 7(B)
[0480] Subject--Human 30 year old Lactating female.
Conditions/Symptoms of Subject
[0481] A 30 year old white female was presented with health
concerns that arose 4 days after leaving hospital after giving
birth to a female child. The patient was in hospital for 3 days and
the condition did not manifest until 4 days post hospital. This was
a second child and the patient did not have a history of
mastitis--mammary gland infections.
[0482] Symptoms included a high fever, painfully swollen mammary
glands with pain extending under left arm. Breasts were extremely
painful to the touch and breast feeding was problematic at best.
General movement was also guarded due to the inflammation and pain
associated with movement.
Treatment
[0483] Three sprays, 2 ml, of the liquid homeopathic medication
complex for mastitis comprising Cores A, B and C (no nosdoes) in
dropper dose in an excipient of 20% ethyl alcohol and 80% purified
water was administered by the subject 3 times daily for 2 days
based on the nature of the condition and the lack of response to
antibiotic therapy on its own.
Result
[0484] Pain was reduced after 3 hours, inflammation was reduced
within 24 hours and a total resolution was achieved in 48
hours.
Conclusion
[0485] The response confirmed that Cores A to C work as an
anti-infective and anti-inflammatory in humans. It demonstrates a
rapid response in humans to the invention and that the invention is
safe and side effect free in humans.
[0486] It shows that the use of Cores A to C internally (this can
also be delivered transdermally, orally, perivaginally or
parentrally) demonstrates a consistent response as a potent
anti-infective agent.
Example 7(C)
[0487] Subject--Human Male 60+ year
Conditions/Symptoms of Subject
[0488] Subject was diagnosed with meningioma and had surgery to
remove the same. As follow up radiation therapy was done 5 days a
week for 6 weeks. The subject presented with itching and soreness
of the skin over the area of radiotherapy, a known consequence of
radiotherapy.
Treatment
[0489] The invention was provided in the form of a cream comprising
Core A and B for topical application in a base carrier of 25%
Lanolin and 50% White Petroleum at 2 oz/lb and 25% Mineral oil with
the homeopathic combination added at 3.33% (3.33 ml/100 ml). The
cream was to be applied to when the skin was itchy and sore after
radiotherapy on an as needed basis.
Result
[0490] As soon as the patient applied the cream the skin conditions
were relieved. The patient was able to complete the radiotherapy
course with simple easy to apply relief when required
Conclusion
[0491] Core A and Core B formulated as a cream works in humans
similar to animals and this is one of a series of similar cases all
with similar positive results. The invention has a rapid and
immediate effect. The invention is effective in treating burns,
burn wounds, itch, soreness and radiation burns.
Example 8
Wound Healing Case Study--Septic Post Surgical Mastectomy Wound
Healing
[0492] Subject--Tabby and White Domestic Short Haired Cat Female
Not Neutered estimated age 6-7 months
Conditions/Symptoms of Subject
[0493] The subject presented as a second opinion case where a
unilateral mastectomy had been carried out due to gangrenous
mastitis. The subject had had the surgery a little less than a week
previous to being brought to us, all her kittens had died prior to
the mother arriving with us from a combination or the initial
malnutrition and sepsis from the mastitic milk. Thus only the
mother was presented and she had continued to deteriorate during
the post surgical period much as had occurred with the kittens. The
subject presented with a fever of T103.5.degree. F. and was already
on Convenia a 14 day duration antibiotic active ingredient
Cefovecin a cephalosporin and was failing to improve. The patient
was in appetent and a large area of tissue was still on the point
of sloughing. The initial presentation was fairly dramatic with a
lack of response to conventional medications (FIGS. 7a to 7d).
Treatment
[0494] The subject was given twice daily oral dosing with 5 drops
or 0.35 ml of the delivery dose was administered by mouth twice
daily. The delivery dose comprised of Cores A, B and C with the
following Nosodes: Tuberculinum Bovinum, Tuberculinium Aviaire,
Staphylococcus Aureus, Strepococcus, Strepococcus Mix,
Corynebacterium, E. Coli (ColibacillinuM), E. Coli, Bacillinum and
Medorrhinum, in a liquid dropper. Cores A, B and C with Nosodes
were combined and added at a rate of 0.07 ml/ml in an excipient in
glycerine 30% with purified water to act as an anti-infective. In
addition cream comprising Core A and B for topical application in a
base carrier of 25% Lanolin and 50% White Petroleum at 2 oz/lb and
25% Mineral oil with the homeopathic combination added at 3.33%
(3.33 ml/100 ml). The cream was to be applied to the open wound 2
to 3 times daily. All antibiotic therapy was discontinued.
Result
[0495] Within 24 hours the non responsive subject had a decrease in
it pyrexia from T103.5.degree. F. to T102.2.degree. F. and had
started eating. The patient has also started drinking again, the
wound still looked appalling, but had a less putrid odour FIG. 7a
and within in 3 days the patient had improved dramatically with the
gangrenous area having sloughed and healing had started to rapidly
occur in the affected area the cat was now eating, drinking,
walking around and purring again.
[0496] Within 7 days the entire wound area was dry an all oozing
gone due to the rapid rate of healing the fact that the patient had
previously been under general anaesthesia for the original surgery
and non responsive treatment Applicants decided to allow the wound
to heal by second intention.
[0497] FIG. 7c--ten days after initiating treatment the patients
wound had reduced in surface area sufficiently for some areas of
the wound to have started to close showing no trace scarring.
[0498] FIG. 7d--at the three week stage healing was virtually
complete and the patient sent home. Further reports on the subject
is that it continues to do well and no one would know the problem
was ever there
Conclusion
[0499] The homeopathic complexes administered are effective in the
presence of resistant infection not susceptible to previously
chosen antibiotic cover and produce a rapid response with a fast
drop in temperature showing the invention acting as an
anti-pyretic. The invention is safe as there were no side effects
seen where the invention was applied both internally and externally
over a large surface area for a prolonged period in a subject. The
invention act as a potent anti-infective composition. The invention
promotes wound healing even in very large septic wounds. The
invention can be co-administered with antibiotics. The invention is
non-toxic, the subject being a cat continually washed the cream off
its coat for the entire duration of treatment and showed no ill
effects. The invention has anti-inflammatory and analgesic
properties as the subject was rapidly able to get up and walk
around. The invention is easy to use due to the above the subject
allowed easy administration of the invention to area that were
obviously sore. The invention can be administered by multiple
routes and by multiple delivery methods.
Example 9
Wound Healing Case Study--Treatment of Mastitis and Mammary
Hypertrophy
[0500] Subject--Domestic Short Haired Cat F <2 years
Conditions/Symptoms of Subject
[0501] The subject had already received treatment before being
brought for a second opinion. The subject had already been given
Convenia, a 14 day duration antibiotic with active ingredient
Cefovecin (a cephalosporin), and had failed to improve over the
subsequent treatment period and had in fact got worse with the
mammary glands continuing to increase in size and discolouration,
the patient had become lethargic and in-appetent, but still
continued to eat some food.
[0502] The subject presented with massive mammary hypertrophy and a
history of what was diagnosed as mastitis. FIG. 8a shows the degree
to which the mammary glands were enlarge discoloured. FIG. 8b shows
the ball that was placed between the glands as a reference to show
the true size of the gland swelling.
Treatment
[0503] The subject was given twice daily oral dosing with 5 drops
or 0.35 ml of the delivery dose was administered by mouth twice
daily. The delivery dose comprised of Cores A, B and C with Nosodes
as per Example 8 in a liquid dropper. Cores A, B and C with Nosodes
were combined and added at a rate of 0.07 ml/ml in an excipient in
glycerine 30% with 70% purified water to act as an anti-infective.
In addition cream comprising Core A and B for topical application
in a base carrier of 25% Lanolin and 50% White Petroleum at 2 oz/lb
and 25% Mineral oil with the homeopathic combination added at 3.33%
(3.33 ml/100 ml). The cream was to be applied to the entire mammary
are 2 to 3 times daily. All antibiotic therapy was
discontinued.
Result
[0504] Within 10 days there was complete resolution of the
condition the speed and rapidity of which is evidenced when one
compares FIG. 8a and FIG. 8b. The glands which were sufficiently
large to hold the ball between them and were much larger than the
1.5 cm ball had within 10 days returned to an almost flat in active
state. A remarkable change considering the starting point and the
lack of response to previous therapies
Conclusion
[0505] Thus, the homeopathic complex of the invention is effective
in the presence of resistant infection not susceptible to
previously chosen antibiotic cover and produces a rapid response
with a rapid reduction in size of the affected mammary glands on a
daily basis.
[0506] The invention is safe as there were no side effects seen
where the invention was applied both internally and externally over
a large surface area for a prolonged period in a subject. The
invention is non toxic.
[0507] The homeopathic composition of the invention act as an
effect anti-infective in cases of mastitis which is both
complementary and synergistic with conventional medication and
promotes healing as demonstrated in this Example.
[0508] The invention can be co-administered with antibiotics.
[0509] Furthermore, conventional treatments for mastitis and
mammary hypertrophy did not achieve the same effect and the nine
day return to normal of the patient in this example was
exceptionally rapid. The authors note a case where the hypertrophy
had been present for 8-12 weeks and after starting after an
injection of delvosterone had continued to get larger on a daily
basis until Delvosterone 11 c was given. In this case the reduction
was slower and damage took longer to heal.
Example 10
Homeopathic Therapy Evaluation for Subclinical Mastitis in
Lactating Holstein Cows
[0510] Field trial were carried out using an anti-infective
homeopathic complex
Materials
[0511] The Mastitis treatment was administered as defined in the
General materials section. Nosodes were not included for the
purposes of this trial. The homeopathic ingredients were extracted
in 95% ethanol (USP, BP, EP) and 10% triple distilled water. The
following carrier was used for the resultant homeopathic complex
20% ethanol and 80% purified water.
Objective:
[0512] The objective of this study was to evaluate the effect of
the homeopathic treatment above, on somatic cell counts and immune
status of cows.
Introduction:
[0513] High somatic cell counts (SCC) in milk are the primary
indicator of an infection in the mammary gland and intramammary
infections result in reduced milk production and lower quality of
milk. Elevated somatic cell counts can be the result of a clinical
or sub-clinical infection or, in some cases, SCC may be elevated in
the absence of a pathogenic organism. Generally, if a cow exhibits
clinical mastitis, then this cow is treated with an antibiotic, by
intramammary infusion or systemically, depending on the severity of
the clinical signs. If a sub-clinical infection is determined from
a microbial culture of the milk, the cow is monitored but not
treated until the end of lactation, since treatment of these cases
during lactation is not usually effective. Treatment at dry-off has
been established to be the most effective treatment for a
sub-clinical mastitis infection. Sub-clinical infections result in
reduced milk production that can be a loss of several thousand
dollars per animal per lactation. In addition, elevated SCC results
in the loss of quality premiums for producers. Therefore, reducing
SCC and sub-clinical infections are beneficial for both animal
health and profitability. Alternative treatments, including
homeopathic treatments, have been suggested as effective treatments
for sub-clinical mastitis or other health concerns for dairy cows.
However, these products have not been adequately researched under
controlled study conditions and the only information available is
from testimonial reports and studies conducted by the industry that
did not have appropriate controls and have not been published. It
is unknown if the product, Mastoblast, is effective in reducing SCC
and if the product can reduce the incidence of intramammary
sub-clinical infections.
Protocol:
[0514] Twenty-four lactating cows from the University of
Connecticut diary herd were selected based on the pattern of
somatic cell counts in milk and the presence of a mastitis pathogen
(sub-clinically infected) from the CT Mastitis Laboratory. Animals
were then paired by SCC, infection status, age and stage of
lactation and randomly assigned to one of the two treatments within
classes of infection status.
[0515] Treatment design was follows:
Treatment A Mastitis treatment [0516] 6 cows with positive cultures
(if possible) [0517] 6 cows with negative cultures Treatment B
Control treatment [0518] 6 cows with positive cultures (if
possible) [0519] 6 cows with negative cultures
[0520] Cows were housed separately by treatment group within the
Kellogg Dairy Centre throughout the study period.
[0521] Cows were aseptically cultured at day -3 and day -1 and day
3 to verify the intramammary infection status and SCC and at least
nine cows will be assigned to each treatment. The homeopathic
treatment and control treatment were administered as a spray on the
nasal membranes for 10 days starting at day 5. Starting at day 2,
milk was sampled from the afternoon milking for SCC analysis every
three days for two weeks. Thereafter, milk was sampled for SCC once
weekly through 8 weeks. Milk was sampled aseptically for pathogen
analysis on a two-week basis up to 10 weeks. Daily milk production
was recorded. Monthly milk fat and protein content was determined
from DHI testing. Blood, from veni-puncture and milk samples was
collected from each animal at twice per week to measure
differential counts of white blood cells to assess immune status in
the cows. Effect of the treatment on SCC, milk production and
immune status was analyzed by ANOVA and the GLM procedure of
SAS.
Materials and Methodology
[0522] The study was 60 days in length. At day 1, foremilk was
aseptically collected from each quarter of all cows and analyzed
for mastitis pathogens at the University of Connecticut Mastitis
Laboratory and bacteriological status of milk samples was
determined by diagnostic procedures recommended by the National
Mastitis Council (1987). Milk was then sampled from the total
milking of each cow on day-1 and analyzed for SCC (Marshall, 1992)
and for the immunoglobulins G.sub.1 (IgG.sub.1) using ELISA
quantitation kits (Bethyl Laboratories, Inc; Montgomery, Tex.).
These values provided baseline nonspecific estimates of the
intramammary infection status of each quarter and the immune system
status.
[0523] On day 1 through day 10, the homeopathic therapy and the
placebo were administered twice daily before each milking. On days
3, 7, 10, 13, 16, 22, 28, 35, 42, 49, and 56 milk was sampled and
analyzed for SCC. On days 3, 13, 22, 28, 35, 42, 49 and 56 the milk
samples were also analyzed for IgG1. In addition, on days 28 and
56, foremilk from each quarter for all cows was aseptically
collected and analyzed for mastitis pathogen as described earlier.
If a cow developed clinical mastitis, the data from that cow were
removed from the analysis due to marked increases in SCC and
immunoglobulins due to clinical mastitis that may bias the
analysis. In this study, the sample size was not large enough to
accurately determine treatment differences for clinical mastitis,
because clinical mastitis is usually a low incidence disease.
Results
TABLE-US-00012 [0524] P Values Treatment Time Treatment time SCC
0.87 0.48 0.46 IgG1 0.006 0.0001 0.0001 IgG2 0.52 0.17 0.0002
Infections 0.12 0.63 0.35 Significant effects from IgG1, only
[0525] These results show significant effects for IgG1 only. The
IgG1 is the only immunoglobulin to show significant change the IgG2
section was affected by the cattle not receiving homeopathy
developing mastitis and having to be removed from the trial. This
factor was not part of the trial results as it was not part of the
parameters to be examined, but the actual incidence of mastitis in
the animals not receiving the homeopathic medication was much
higher than those who received the homeopathic medication. The
change in the significant changes in IgG1 may have been related to
the reduced incidence of mastitis. The lack of change in IgG2 may
have been related to the masking of this effect by the intrusion of
clinical mastitis into the trial in the non homeopathic
group--without this there may also have been a change in IgG2. Both
IgG's have been associated with mastitis and conferring protection
against mastitis in cattle (see FIGS. 9a and 9b).
Conclusion
[0526] Applicants found that the actual incidence of mastitis in
the animals not receiving the homeopathic medication was much
higher than those who received the homeopathic medication. Thus,
the conclusion is that an effect in IgG1 was seen while the animals
were on homeopathic treatment.
Example 11
Wound Healing Case Study--Accelerated Wound Closure and Healing
[0527] Subject: Jack Terrier, male neutered, 10 years old
Conditions/Symptoms of Subject
[0528] The patient presented in shock with multiple bite wounds,
which were acutely painful, with difficulty in breathing and the
danger of an injured trachea temporarily ruled out treatment under
general anaesthesia.
[0529] Examination of the wounds revealed that the bites had
penetrated through the skin to cause substantial damage to the
underlying muscles at the junction of the neck and chest between
the axillae, around the dorsal aspect of the left foreleg, and over
the rib cage on the left side.
Treatment
[0530] Initial therapy included clipping the wounded area and
washing the skin margins with Hibiscrub surgical scrub followed by
povidone iodine. The open wound was then bathed in sterile water
with Homeopathic Mother tincture of Calendula (Marigold), at a
dilution of 20 drops of mother tincture add to 100 ml of sterile
water. The wound was gently dabbed dry and Vet Cream (Core A and
Core B in the form of a cream) was liberally applied to the entire
affected area and the surrounding tissue close to the wound margin.
The owner was instructed to apply the cream to the affected area
2-3 times daily.
[0531] When wound treatment was complete the patient was given a
single 15 drop dose of Trauma/First Aide Complex. Antibiotic cover
was instigated with a single 0.5 ml intramuscular injection of
Synulox RTU (Pfizer Animal Health). Maintenance of antibiotic cover
was supplied by Synulox 250 mg tablets (Pfizer) at a dose rate of
1/2 a tablet twice daily for 5 days.
Results
[0532] Two days after the initial consultation the tissue around
the wounds was obviously bruised, but dramatically less. The
painful breathing initially apparent on the day of presentation was
considerably better and the fluid from the underlying lacerated
muscle layer was draining from the wounds. A decision was taken not
to suture the wounds weighing up the benefits of the drainage as
well as the absence of sepsis and the dramatic decrease in
pain.
[0533] Seven days after the initial attack, the wounds were already
closing over and there was no evidence of bruising or local skin
damage (see FIGS. 10a to 10c).
Conclusion
[0534] The rapidity of healing is very clear where there is a total
disappearance of tissue bruising and all surface injuries, other
than the major wound points, had literally vanished. In the same
period the wound holes themselves had produced healing edges and
had filled in the open areas completely. In general with wounds
like this one expects sepsis or at the very least a large amount of
tissue swelling and bruising that lasts some weeks and that a drain
might be required. In a patient with no anti-inflammatory or
analgesic treatment (as in this case) one would not normally have
expected the patient to be fully mobile in two days.
Example 12
Wound Healing Case--Bite wound Healing Conditions/Symptoms of
Subject
[0535] The patient (canine) originally presented with what was
thought to be a self inflicted skin condition from scratching,
described as hair coming off with scabby eruptions. However, on
further examination this appeared to be like that of a dog that had
been savaged and the area around the eye in fact looked like a
wound rather than a self inflicted injury.
Treatment
[0536] Considering that the initial appearance of the skin
resembled that of a traumatic wound, it was decided to treat the
presenting signs rather than any underlying condition as no
underlying cause could be determined.
[0537] Vet Cream (Core A and Core B in the form of a cream) was
administered. Sulphur 9.times. (Sulphur at a dilution 1:10.sup.-9)
homeopathic was also supplied to be used on a twice daily basis
just in case the owners assumption of a parasite cause such as
sarcoptic mange was correct and to provide a non steroid
anti-puritic effect. However, this was stopped after confirmation
from the owner that the wounds were the result of a fight, and
administration twice daily of the Vet Cream was continued.
Results
[0538] The area below the eye with the open wound had completely
disappeared in the intervening five weeks, with no trace of an open
area. No trace of any wound was visible on the dorsal area.
Example 13
Wound Healing Case Study--Treatment of a Simple Slow Healing
Wound
[0539] Subject: blonde coated Lurcher, Female Neutered, 14 months
old
Conditions/Symptoms of Subject
[0540] The patient was presented three weeks after the initial
injury with an incised-type wound that although small just would
not heal.
Treatment
[0541] No antibiotic cover was provided during treatment, nor were
any anti-inflammatories either topical or oral used during the
treatment of this case. The only treatment used from the initial
presentation to final cure was Vet Cream (Core A and B in the form
of a cream) on a twice daily basis till the wound appeared to be
healing and then to apply it once daily.
[0542] Within two days of starting the application of Vet Cream the
wound had started to heal and the owner reduced application of the
cream to once daily. Within six days the wound had healed
completely.
Example 14
Wound Healing Case Study
[0543] Subject: Greyhound Brindle & White Neutered Male 7 years
old
[0544] Conditions/Symptoms of Subject The injury was caused by
running under a wooden pole and him catching his back on a
protruding nut. The skin on the back literally peeled back.
Treatment & Results
[0545] The wound was repaired under general anaesthesia 0.1 ml
Acetylpromazine 2 mg/ml IM as premed and Thiopentone 2.5% IV to
effect (15 ml used) as a knockdown dose and anaesthesia was
maintained with Halothane. There was 90 minutes of surgical time
excluding the time taken for preparation of the wound for surgical
repair which included clipping the area and washing the skin
margins with Hibiscrub surgical scrub followed by povodine iodine.
The open wound was then bathed in sterile water with Homeopathic
Mother tincture of Calendula (Marigold) at a dilution of 20 drops
of mother tincture add to 100 ml of sterile water. The wound was
then sutured using mattress sutures to appose the edges, as the
patient had a history of tearing wounds open. The large areas which
were unattached to the underlying facial tissue were tacked down
using single interrupted sutures to enhance the chances of
reattachment. A decision was taken not to insert a drain into the
wound initially. When wound repair was complete the patient was
given a single 15 drop dose of Trauma/First Aide. Antibiotic cover
was instigated with a single 2.5 ml intramuscular injection of
Synulox RTU (Pfizer). Maintenance of antibiotic cover was supplied
by Synulox 250 mg tablets (Pfizer) .times.15 at a dose rate of 11/2
tablets twice daily.
[0546] Vet Cream (standard combination Core A and B in the form of
a cream) was liberally applied to the entire affected area and the
surrounding tissue close to the wound margin. The owner was
instructed to apply the cream to the affected area 2-3 times daily.
The patient had an uneventful recovery despite the degree of
degloving and the extent of the wound and the previous history of
the patient's wounds breaking down. The antibiotic cover was not
extended beyond the initial 5 days and no analgesic or
anti-inflammatory other than the Vet Cream was used. There was no
wound breakdown nor was there any need for a drain in the wound
despite its extensive size, which is a common event with injuries
such as this.
Example 15
Severe Bruising (Case with Two Fractured Legs)
[0547] Subject--Labrador cross Retriever male 1 year old
Condition
[0548] Both hind legs were fractured as a result of a car impact.
The damage done to the car indicated that the patient was lucky to
be alive.
[0549] The endrotracheal tube used to intubate the patient during
anaesthesia was covered in blood indicating severe damage not just
to the legs but also to the lungs with some degree of
pneumothorax.
Treatment
[0550] The subject received three doses of Trauma/First Aid in the
first twenty four hours, and then once daily for three days. The
entire bruised area had a formulation of Vet Cream (Core A and Core
B) applied on a daily basis for the first five days. The subject
was also placed on Clindamycin 22 mg/Kg twice daily for the initial
5 days but no anti-inflammatory or analgesic drugs were
required.
[0551] By the end of the 5 day treatment period the subject was
considered recovered to the point of being able to support weight
on the legs. The subject also removed his sutures after less than
twenty four hours following presentation, but as the wound remained
closed this healed uneventfully despite the severe bruising of the
immediate tissue. This case indicates that the Trauma/First Aid
treatment promoted rapid healing, promoted extremely rapid
resolution of the wounds, bruising and fractures. What is
unexpected for an injury such as this is the speed of recovery and
the disappearance of all bruising in less than 6 days such that the
subject was able to put weight on both back legs.
Example 16
Use of Anti-Infective Core A for Paw that was Golf Ball Sized Due
to Bite Abscess
[0552] Subject: Cat 3 years Condition: Injured paw with bite
abscess
Treatment
[0553] Core A at a low C potency was administered to the subject in
liquid form for oral mucosal administration.
TABLE-US-00013 Concentration Remedy Vol/Vol % Potency Hepar
Sulphuris 25% 6c Lachesis 25% 6c Mercurius 25% 6c Solubilis Silica
25% 6c
[0554] The above homeopathic complex was supplied in a base of 20%
alcohol and 80% water, as well as second base of 30% glycerine and
70% purified water. Both were administered to the same patient to
assess if any difference in efficacy could be noted and both worked
equally well.
[0555] The paw on Day 1 is shown in FIG. 11a and 11b.
[0556] At day 10 the subject was putting equal weight on both
feet.
Example 17
Use of Anti-Infective Core A
Subject & Condition:
[0557] Canine presented with anal gland abscess. FIG. 12a shows, on
Day 1, an Anal Gland Abscess (arrowed) in the Left anal gland where
the whole L side of the peri-anal area was extremely swollen and a
sinus was discharging pus
Treatment
[0558] The pus was cleaned away from the sinus and the midline and
showed how much the area was swollen. The patient was given Core A
only in high potency, above 200 c, for oral administration.
TABLE-US-00014 Concentration Remedy Vol/Vol % Potency Hepar
Sulphuris 25% 200c Lachesis 25% 200c Mercurius 25% 200c Solubilis
Silica 25% 200c
[0559] The above homeopathic complex was supplied in a base of 20%
alcohol and 80% water, as well as second base of 30% glycerine and
70% purified water. Both were administered to the same patient to
assess if any difference in efficacy could be noted and both worked
equally well.
[0560] No other form of medication (including antibiotics) was
used. On Day 3, the wound was no longer discharging pus and the
swelling in the area was vastly reduced.
[0561] As the abscess had cleared, a Vet Cream (comprising Core A
and Core B in the form of a cream) formulation was applied to the
affected area to enhance the healing. FIG. 12b shows the anal gland
abscess on Day 7 which had completely cleared and the sinus was
completely closed. 4 days after administration of Vet Cream
complete resolution of the wound had occurred. Both the speed of
abscess and wound resolution in this case were remarkable.
Example 18
Subject & Condition
[0562] A surface tissue injury to the left thumb of a human subject
caused by the trapping of the thumb between a power hose and a
granite stone.
Treatment
[0563] The injury was treated with Vet Cream (Core A and Core B in
a cream) which was liberally applied to the entire affected area
and the tissue immediately surrounding the wound margin.
[0564] Within 24 hours following treatment with Vet Cream
Formulation the left thumb showed a significant degree of healing
allowing the subject to continue to work manually with dirt and
water and no protective covering on the wound. Despite regular
immersion in water during the subject's work day, the wound healed
further (data not shown).
[0565] Two days from the initial injury and after a full day's work
again, which includes manual labour and immersion in water while
being unprotected, it was observed that further rapid healing had
occurred despite it being on a point of flexion where healing is
usually much slower.
[0566] Less than one month after the original injury (Day 27), the
wound was entirely healed despite continuous manual work and daily
immersion in water.
[0567] This example demonstrates how effective the Vet Cream
Formulation is in treating human injuries as well as animals under
even more rigorous conditions than would normally be expected, as
the wound was on a flexing region and was immersed daily in water
and subjected to hard manual work.
Example 19
Subject & Condition
[0568] The subject presented with severe bruising and pain around
the ankle joint and foot immediately after a hamstring injury.
Treatment
[0569] Trauma/First Aid treatment was taken three times in the 8
hours post injury and Vet Cream (Core A and Core B in a cream
formulation) was applied to the area of the injury and the area of
subsequent bruising.
[0570] The cream was applied twice daily for 3 days in morning and
evening and then daily for 3 days. After that the cream was applied
approximately every 2.sup.nd day twice daily.
[0571] A similar injury had occurred to the opposite leg a few
years previously which took in excess of 6 weeks to recover and
walk without a leg stocking to keep down the oedema, swelling, and
bruising. In this case where the subject was treated with the
Trauma/First Aid treatment and Vet Cream Formulae, the subject was
walking reasonably comfortably by the 7.sup.th day post injury, and
by the 15.sup.th day post injury the subject was back cycling
despite the fact that the initial assessment of the injury was much
worse.
Example 20
Wound Healing Case Study--Treatment of a Septic Compound Fracture
and Accompanying Wound
[0572] Subject: Black and White Domestic Shorthaired Cat MN less
than 1 year old
Conditions/Symptoms of Subject
[0573] The subject had been presented to two different veterinary
surgeries. The first veterinary surgeon had given Betamox LA
(suspension containing 150 mg/ml amoxycillin as Amoxycillin
Trihydrate BP) at the correct dose of 15 mg per kg bodyweight and
was given further antibiotic cover provided by a single long acting
injection of Convenia at the correct dose of 8 mg cefovecin/kg body
weight (1 ml/10 kg body weight of) by a second veterinarian
surgeon. About 24 hours after returning to his carriers the wound
started to discharge pus again, but it was decided to wait as the
patient was on Convenia and improvement might still occur. However,
the wound continued to discharge purulent material.
Treatment
[0574] On initial presentation the affected region produced a
profuse purulent discharge, which was foetid in odour, when pressed
and the whole area felt like it might slough due to the purulent
undermining. The femur could be felt under the skin and had
obviously penetrated through the wound site, before slipping back
in giving a compound fracture. The wound was flushed with Calendula
& Echinacea Mother tincture diluted at a rate of 20 drops (1
ml) per 100 ml of Sterile water and 1 ml of Antirobe (clindamycin
hydrochloride) 100 mg/ml. The subject was also injected with
Antirobe (clindamycin hydrochloride) 100 mg/ml at a dose rate of 22
mg/Kg. A request was put in to the original veterinary practice for
a full case history and x-rays, which are shown in FIGS. 13c and
13d.
[0575] The condition of the leg following a 2.sup.nd flushing with
Calendula Echinacea and Clindamycin solution was improved, with the
discharge being less purulent. However, some small clots of pus and
necrotic debris could still be seen in the serous discharge that
still came profusely from the wound.
[0576] A decision to surgically repair the leg, if possible, was
taken. FIG. 13f shows that some of the muscle shearing caused by
the distal portion of the femur which perforated the skin had
become septic.
[0577] Pre-surgery the subject was put on a daily injection of
Antirobe (clindamycin hydrochloride) 100 mg/ml at a dose rate of 22
mg/Kg. The subject was anaesthetised using xylazine and ketamine as
knock down agents and maintained in isoflourane. A decision to try
and repair the leg was taken at this point and surgical
intervention was under taken to attempt a full reduction of the
fracture site. When the lower portion of the femur was exteriorised
both veterinarians involved in the surgery were absolutely taken
aback by the absolutely foetid odour of the distal femur,
particularly the bone marrow. A decision was taken remove as much
bone marrow as possible and then to wash out the cavity with a
homeopathic complex consisting of Echinacea, Hepar Sulph,
Calendula, Symphytum and Gunpowder in various potencies, chosen on
the basis of the foetid odour and the osteomyelitis. 500 l of
Clindamycin 100 mg/ml was also introduced into the cavity. An
intramedullary pin of a size smaller than would normally be used
was introduced into the upper fragment of the femur and then into
the lower portion of the femur resulting in a complete reduction of
the fracture. Crystapen as a white soluble dry sterile powder,
containing 95.7% w/w Sodium Benzylpenicillin BP, for reconstitution
(with Water for Injection Ph. Eur), in bottles containing 5
mega-units (3 g) at a dose of rate of 10 mg/Kg and Antirobe
(clindamycin hydrochloride) 100 mg/ml at a dose rate of 22 mg/Kg.
were introduced directly around the fracture site. The wound was
then closed with simple interrupted cat gut sutures for the
internal layers and the skin wound was sutured using polyamide
sutures.
[0578] FIG. 13a and FIG. 13c show the post surgical wound site with
Vet Cream applied and it shows the sinus tract to the infected
bone. Immediately post surgery 10 drops of Trauma/First Aid
treatment was given.
[0579] Post surgical care involved cage rest for 26 days. Initially
twice daily applications of Vet Cream were done, a 10 day course of
Clindamycin 100 mg/ml at a dose rate of 22 mg/Kg IM, a 5 day course
of Silica 200 c homeopathic in liquid Solution was administered at
a dose rate of 5 drops twice daily. Subsequent to stopping the
treatment, the subject was started on Calc Phos homeopathies in
high potency daily for 3 days to improve bone healing and Symphytum
in low potency was administered twice daily at a different time of
day for 10 days. Both were administered away from food.
[0580] Twenty four hours after surgery the patient's wound was
already healing well and the sinus had actually closed. Probiotics
and Prebiotics were given for the first 10 days and neither
anti-inflammatories nor were analgesics administered. The subject
was attempting to walk from the next day, which is a common result
where Trauma/First Aid has been used with Vet Cream.
[0581] Just two days after surgery, the subject was standing
unsupported on the injured leg and the large open wound is already
starting to heal. Also, it was noticed that with Vet Cream
treatment, hair re-growth is enhanced as well as wound repair.
[0582] As the subject developed a liking to the taste of the Vet
Cream, it was necessary to simply apply the Vet Cream just as the
subject was being fed. In addition, the subject was still being
given Clindamycin daily, probiotics, Vet Cream a course of Silica
200 c at this point.
[0583] FIG. 13b demonstrates that merely 11 days post surgery, the
subject's wound has dramatically healed. What is also of note is
the level of hair re-growth as can be seen when compared to FIG.
13a.
[0584] At this point it was decided to temporarily stop applying
the Vet Cream and allow the wound to heal as it was doing. What was
remarkable was that little healing took place over the next 10
days. As such, Vet Cream was reapplied daily for a couple of days
which once again promoted not just rapid healing but further hair
growth prior to the subject's discharge.
Conclusion
[0585] Both veterinarians and the nurse involved had not expected
this case to resolve following surgical intervention based on the
incredibly foul sepsis at the time of the surgery. Apart from all
the other factors mitigating against recovery, the initial lack of
response to antibiotic cover and the introduction of a foreign
substance in the form of an intramedullary pin into such septic
circumstances would normally further add to the difficulty in
having any success in clearing up the sepsis. The results obtained
were completely unprecedented.
[0586] Furthermore, in a large number of cases enhanced tissue
regeneration has been seen with hair regrowth. Such enhanced tissue
regeneration appears to extend to septic bone healing in this case.
The patient returned to normal function extremely rapidly
demonstrating an analgesic effect, a tissue restoration effect
covering hair skin, muscle, connective, and bone tissue while at
the same time enhancing organ function recovery.
Example 21
[0587] A 9 year old female, spayed SharPei/Lab Mix that was hit by
a snow plow. She also suffers from epilepsy and SharPei Fever. She
was far enough on her driveway that it only severed the lateral 2
digits off her right front paw.
[0588] The results from the HP Vet Cream (Aconitum Napellus
3.times., Arnica Montana 3.times., Arsenicium Iodatum 6.times.,
Belladonna 3.times., Bellis Perenis 3.times., Bryonia 3.times.,
Calendula Offcinalis 3.times., Chamomilla Matricaria 3.times.,
Echinacea Angustifolia 3.times., Exchinacea Purpurea 3.times.,
Graphites 8.times., Mamamellis Virginia 3.times., Hepar Sulphuris
3.times., Hypericum Perforatum 3.times., Lachesis 8.times., Ledum
3.times., Millefolium 3.times., Mercurius Solubilis 6.times.,
Phytolacca 6.times., Ruta Graveolans 3.times., Rhus Toxicodendron
3.times., Silica 3.times., Stellaria Media 3.times., Sulfur
3.times., Symphytum 3.times. And Thuja 3.times.) were very
impressive. The owners started with daily sugar bandages for 11
days, then switched to daily furacin bandages for 10 days, and HP
cream for 14 days.
[0589] The results are depicted in FIGS. 14A-14G. FIG. 14A depicts
the initial accident, FIG. 14B depicts the furacin bandages started
and Baytril for 14 days, FIG. 14C depicts the efucain bandages
stopped and the HP healing cream started, FIG. 14D depicts 6 days
after HP cream started, FIG. 14E depicts 14 days after HP healing
cream was started, FIG. 14F depicts one month after HP healing
cream was started and FIG. 14G depicts three months after the
initial trauma. As indicated in FIG. 14G, the wound is almost
completely healed three months after the initial trauma.
Example 22
Wound Healing Case Studies: Integrating a Homeopathic Approach with
Conventional Medicine for Favourable Outcomes
[0590] The primary focus of skin lesion management is thorough
removal of all foreign material and of all devitalized or
contaminated tissue. Effective debridement can reduce but not
completely eliminate the concern about infections. To this end, it
is a clinical judgement as to the need for antibiotic therapy, and
if used whether it should be applied topically, administered
systemically or a combination of both. Additionally, sutures and/or
bandaging can help provide protection and structural support that
will facilitate wound healing. Nonetheless, even for the most
skilful veterinarian, some wounds and non-traumatic skin lesions
just will not heal.
[0591] One aspect of wound healing on which few data are available
concerns the use of homeopathic treatments. Whether as part of
routine wound management or in situations of refractory wounds,
homeopathic remedies can be a valuable addition to the clinician's
armamentarium. To this end, a homeopathic cream has been developed
and tested clinically to determine its utility in clinical
practice. The following example presents a number of case studies
that suggest that use of the cream facilitates wound healing in
dogs in a range of varied situations.
Case Study 1: Trauma-Induced Foreleg Injury in a Bichon Frise
[0592] After being hit by a car, a 7 year-old, male, neutered
Bichon Frise suffered a penetrating wound through the full depth of
the dermis of the medial aspect of the left forelimb, extending
from the proximal metacarpus to the axilla. Radiological
examination indicated no bone damage had occurred and there were no
additional injuries. Under general anesthesia, the hair bordering
the wound was clipped and the wound debrided. However, the extent
of skin damage, and high risk of wound contamination and secondary
infection precluded suturing. Topical antibiotic was applied, the
wound was bandaged and the patient was sent home on daily oral
trimethoprim (5 mg/kg)/sulphadiazine (25 mg/kg), and carprofen
tablets (2 to 4 mg/kg/day).
[0593] Three days later, the dog was bright, but there was no
evidence of healing, and an extensive malodorous, purulent
discharge had matted the hair beyond the border of the wound. The
owner rejected a second general anaesthetic, but the dog's docile
temperament allowed cleansing of the wound with a water/antiseptic
solution and povidone iodine. The dog was sent home with owner
instructions to keep the wound as clean as possible using saturated
salt water. Five days later, the wound had not improved and the
antibiotic was changed to 50 mg clindamycin twice daily, and the
owner was instructed to clean the wound with a homeopathic mother
tincture calendula (marigold) twice daily (20 drops in 100 ml of
sterile water).
[0594] Two weeks after the initial injury (FIG. 15A), healing was
not occurring and the wound continued to emit an odour. The dog was
again anesthetized and the wound was clipped, cleaned and bathed in
the homeopathic mother tincture calendula and tension sutures were
placed, systemic antibiotic therapy was halted and the owner
consented to trial a developmental homeopathic cream (HP Vet
Cream.RTM.). After the wound had dried the cream was liberally
applied along with antibiotic ointment. Twenty days after the
initial injury, and 6 days after the second anaesthetic there was
substantial improvement (FIG. 15B), and from this point the owner
ceased all other treatment, but continued applying the cream (FIGS.
15C and 15D). Approximately one year after the accident, the dog
showed complete healing with minimal scarring and almost complete
hair regrowth (FIG. 15E).
Case Study 2
[0595] A 4 year old neutered male Beagle presented with a
persistent, circular, purulent wound with necrotic skin on the
right pinna (FIG. 16A). Although the etiology was unknown, the
owner suspected that the wound originated from a spider bite. The
dog was administered systemic antibiotic (penicillin injection),
and the owner was provided with amoxicillin and HP Vet Cream for
application twice daily for one week (FIG. 16B). The dog was
re-presented 10 days later for a recheck when the wound was
significantly reduced in diameter with no sign of infection (FIG.
16C). The owner was advised to continue applying the cream and the
dog recovered uneventfully.
Case Study 3
[0596] A 2-year-old female crossbreed dog was presented with an
open wound in the right inguinal area that penetrated through the
superficial muscle layer (FIG. 17A). The wound appeared clean and
antibiotics were not considered necessary. HP Vet Cream was the
only treatment advised, to be applied to the wound twice daily.
FIG. 17 shows the progressive improvement in the condition of the
wound at 2 weeks and 4 weeks post initial presentation.
[0597] Case Study 4.
[0598] A 6 year-old spayed female, mixed breed dog presented with
an open wound on the medial aspect of the left stifle. The wound
was approximately one inch in diameter and appeared inflamed and
granulomatous (FIG. 18A). The dog was given an injection of
penicillin and the owner dispensed 2 weeks supply of
amoxicillin/clavulanic acid tablets. As adjunctive therapy, HP Vet
Cream was applied, and dispensed for twice-daily application. At
examination 2 weeks later, the wound was almost completely healed
with new hair growth present and no evidence of infection (FIG.
18B). The only treatment advised at this time was to continue twice
daily application of the homeopathic cream. Two weeks later, the
wound appeared to be completely healed (FIG. 18C).
Case Study 5.
[0599] A neutered, 7 year-old male greyhound suffered an extensive
full depth skin shearing injury of the dorsum by running under a
pole from which there was a protruding nut. The extent of affected
skin area is shown by the arrow in FIG. 19A. The wound was debrided
and cleaned under general anaesthesia, including bathing in sterile
water with homeopathic mother tincture of calendula (marigold) at a
dilution of 20 drops of mother tincture add to 100 ml of sterile
water. Mattress sutures were inserted to appose the wound edges,
with supporting subcutaneous sutures. Antibiotic cover was
instigated with intramuscular amoxicillin/clavulanic acid and
maintained with twice daily oral administration for 5 days. HP Vet
Cream was liberally applied to the affected area and the owner (a
veterinary nurse) was instructed to apply the cream to the area at
least twice daily. At follow up visits the dog appeared to be
recovering well and at a routine visit 12 months after the surgery,
the wound was seen to have healed well.
[0600] In describing four separate cases of trauma induced wounds,
this paper demonstrates the potential for integration of a
homeopathic cream into conventional approaches to managing a range
of skin lesions presented for veterinary treatment. In the first
case, a wound that was refractory to initial conservative treatment
with debridement and antibiotic showed rapid improvement following
a change in antibiotic and the application of HP Vet Cream.
Similarly, a combination of antibiotic with HP Vet Cream (Case
Study 4) produced a good healing response in an infected stifle
wound, and in the most severe wound (Case Study 5), a comprehensive
surgical intervention, combined with topical and systemic
antibiotic administration and at least twice daily application of
HP Vet Cream produced a full cure.
[0601] Not all traumatic wounds described in this paper required
supporting antibiotics--in one case of (Case study 3), a deep
penetrating wound responded quickly and thoroughly to application
of HP Vet Cream without any additional therapy. One case report
(Case study 2) described the favourable response of a wound of
unknown origin to combined therapy with the HP vet cream and
topical antibiotic.
[0602] In case studies such as those described in this paper, it is
not possible to define which of a number of interventions produced
a cure, or if it was the exact combination of components together
that was responsible. However, the positive healing response in
which HP Vet Cream was used alone (Case study 3) does suggest that
it offers properties that can enhance wound healing. Regardless,
the cases reported here raise expectations that HP Vet Cream, as
either a single agent or in combination with other topical and
systemic therapies such as antibiotics, has the potential to be a
valuable addition to the clinician's armamentarium, whether or not
surgery and suturing is utilized.
Example 23
Additional Case Studies
[0603] The disclosures of the case studies on
http://www.homeopetpro.com are hereby incorporated by
reference.
Case # 142: 4 yr Old Neutered Male Beagle
[0604] Patient presented with a "sore" on right pinna. It was
suspected that the wound was from a possible spider bite. Wound was
a circular wound with necrotic skin and pus exuded. Patient was
given an injection of penicillin. Wound was clipped and scrubbed
with beta dine solution. Patient was sent home with Amoxitabs twice
daily for one week. The Homeopet cream was prescribed for two times
per day. Pictures taken are illustrated at FIG. 20A. Patient
returned 10 days later for a recheck visit. Wound was significantly
reduced in diameter and infection was not present. Owner was
advised to continue Homeopet cream. Photo taken is shown at FIG.
20B.
[0605] Case #143 11/2 yr Old Spayed DSH Feline
[0606] Patient presented as non-weight bearing on right front leg.
Upon further examination an open, infected, necrotic wound was
found. Leg was previously swollen per owner before bringing patient
in. Wound was approximately the size of a nickel. Patient was given
a convenia (antibiotic injection) and Homeopet cream prescribed.
Photos taken are shown in FIG. 21A. Patient was brought in for a
recheck visit after 2 weeks. Wound was almost completely healed.
Infection was not present and fur was already growing back. Wound
was approximately the size of a pea and basically just scabbed
over. No further treatment except Homeopet Cream was advised.
Photos taken are shown in FIG. 21B.
Case #144 2 yr Old Unneutered Shih Tzu Mix
[0607] Patient presented after being hit by a car. Oxygen was given
and IV cath was placed. PCV & Total Protein values were
obtained. Patient was sedated with Ketamine and Domitor. X-rays
were taken. No significant problems were noted on the x-rays.
Abrasions were clipped and cleaned with beta dyne solution. Patient
was given an injection of penicillin and metacam. The abrasions
were treated with Homeopet Cream. The patient was sent home the
following day with pain medication (Novox 75 mg) and Homeopet Cream
twice daily for the multiple abrasions in the inguinal area. Owner
was advised to bring patient in two weeks for a recheck visit.
Photos taken are shown in FIG. 22.
Case #145 2 yr Old Female Mix Breed Canine
[0608] Patient presented with a wound on the right back side. The
wound was granulating, non-smelly but open wound in right inguinal.
It was suspected possibly a knife injury--had separation of muscle
fibers. Homeopet Cream was the only treatment advised. Patient
received Homeopet Cream twice daily. Photos taken are shown in FIG.
23A.
[0609] Patient returned 2 weeks later for recheck visit. Wound
healing well. Photos taken are shown in FIG. 23B. In a recheck
visit 2 weeks later, the wound was completely healed at this date.
A small scar was present; fur was already trying to come in and
cover where wound used to be. Photos taken are shown in FIG.
23C.
Case #146 6 yr Old Spayed Female Canine (Brown)
[0610] Patient presented with an open wound on inside of left rear
leg, possibly from a metal shingle. Wound was quarter sized and
very inflamed. The patient was given an injection of penicillin and
put on Clavamox for 2 weeks. Homeopet Cream was advised and given 2
times daily. Photos taken are shown in FIG. 24A.
[0611] Patient returned 2 weeks later for a recheck visit. Wound
was almost completely healed. New hair growth was present. Wound
was now dime sized and healing very well. No infection was present.
The only treatment advised at this time was to continue the
Homeopet Cream. Photos taken are shown in FIG. 24B.
[0612] The patient returned 31/2 weeks later. The wound was healed
and a small scar present. Photos taken are shown in FIG. 24C.
Case #147 10 yr Old Female/Spayed Collie
[0613] Initial Exam: Presented red inflamed, malodorous skin. The
patient also had difficulty in getting up and down--in obvious
pain. A deep pyoderma and a decubitus ulcer were found on the right
elbow. There were multiple papules and pustules all over skin. The
patient was in obvious pain as the ulcer was on a pressure point on
the elbow.
[0614] The patient was given an injection of penicillin and
prednisone. Patient was sent home with follow up antibiotics and
prednisone tablets. The Homeopet vet cream was advised to be used
two times daily. Photos taken are shown in FIG. 25A.
[0615] Patient came in for a recheck visit after 3 weeks. The area
on right elbow was slightly improved. Patient was still scratching
constantly. New hot spots were forming on the right hip and rump.
Patient was given another injection of steroid (Depo Medrol) and
penicillin. Patient was sent home with 2 more weeks of antibiotics
and prednisone tablets. Photos taken are shown in FIG. 25B.
[0616] Patient came in for another recheck after 3 more weeks. Foul
odor, scabs and sores were still present on skin. The ulcer on
right elbow was still present but not as deep. Patient was sent
home with more prednisone tablets. A new antibiotic was started on
this date (Primor 100 mg). Patient also was given another steroid
injection (Dep Med). A second bottle of Homeopet cream was sent
home with the patient. Patient was advised to do a recheck visit in
30 days and never returned. Photos taken are shown in FIG. 25C.
Case #148 6 mth Old Spayed Female Miniature Pinscher
[0617] Patient presented with dewclaw incision site open. The
patient had an ovarian hysterectomy and front dewclaw removal 5
days prior. The dewclaw incision site opened presenting open
wounds. The wounds were open, red and dime sized. The dewclaw
surgery site on both front paws was open but granulating well. The
patient was enrolled in the Homeopet Cream study. The owner was
advised to apply the Homeopet cream to both dewclaw surgery sites
twice daily. This was the only treatment advised. Photos taken are
shown in FIG. 26A.
[0618] The patient was brought in 2 weeks later for a recheck. The
wounds were almost completely healed--now pea sized. The fur was
almost completely regrown. The owner was advised to continue
Homeopet Cream. Photos taken are shown in FIG. 26B.
[0619] The patient returned 3 weeks later for another recheck.
Small scars were present but wounds were completely healed. Photos
taken are shown in FIG. 26C.
Case #149 4 mth Old DSH Kitten
[0620] Patient was presented with a possible woof wound on ventral
neck. Wound presented was open (1/2 dollar sized) with muscles
exposed and odor present. The patient was sedated with 25 mg
Telazol. The wound was clipped, scrubbed with Technicare. The
patient received an injection of penicillin and Metacam. Patient
was started on Amoxi Drops twice daily and Homeopet Cream. The
patient's rear right leg was bandaged so that the patient would not
be able to cause more damage from scratching at wound. Photos taken
are shown in FIG. 27A.
[0621] Patient returned 21/2 weeks later for a recheck visit. The
wound was almost completely healed with small scar present. Fur was
already growing in and wound was 1/4 the original size. No further
treatment but Homeopet Cream was advised. Photos taken are shown in
FIG. 27B.
Example 24
Human Studies
[0622] A 33 year old Male patient with stage 3 renal failure and
childhood diabetics had a non responsive ulcerated would on the
left foot is depicted in FIG. 28A. The wound had been treated with
conventional, antibiotics, Hyperbaric chamber, formal surgical
wound debridement and wound edge cleaning treatments over a three
year period with no success. After just five weeks of once daily
treatment with Eycnan LL's Nan's Healing Cream, (the name of the
present invention employed in the human market), the improvement is
shown in FIG. 28B. This level of response is both dramatic and
unexpected based on the lack of response to previous treatments
clearly demonstrates that the cream is as effective in humans as it
is in animals.
[0623] An 53 year old male patient with a chronic non responsive
wound that was treated with conventional antibiotic coverage and
Hyperbaric chamber, formal surgical wound debridement and wound
edge cleaning treatments over a one year period with no success
depicted in FIG. 29A. After 3rd week of cream and compression
dressing, the improvement is shown in FIG. 29B. The improvement
after an additional week is depicted in FIG. 29C. The wound closure
in just four weeks is based on once daily application of the cream
in the wound center.
[0624] An 83 year old male patient with a chronic non responsive
wound to the right leg was treated with conventional antibiotic
coverage and Hyberbaric chamber, formal surgical wound debridement
and wound edge cleaning treatments over a one year period along
with alternating wet to moist compression bandaging is depicted in
FIG. 30A. The next week, cream with compression dressing was added
as depicted in FIG. 30B. The improvement after the fourth week of
treatment is depicted in FIG. 30C. During the 6th week of
treatment, compression dressing is no longer needed as shown in
FIG. 30D. The improvement two months after the depiction in FIG.
30A, is shown in FIG. 30E.
Example 25
HomeoPet Pro HP Healing Cream Case Studies
[0625] The cream of the present invention, as exemplified by the
present example, has proven to be effective on previously
non-responsive wounds. The cream creates a protective barrier
around a wound and may be used on open or bandaged wounds. The
cream also possesses anti-infective actions, has no known negative
drug interactions, is anti-inflammatory and has no known
contradictions. The cream is in a safety sealed tube for ease of
application to a wound site.
[0626] The healing effect is transferred over the entire wound. As
shown in FIG. 31A, septic post surgical mastectomy wound healing
with a large area of slough due to purulent under run of skin
tissue which was non responsive to the initially selected
antibiotic cover in a patient with a febrile state. FIG. 31B
demonstrates that the response of this patient to just the use of
HP Anti-infective Solution and HP Vet Cream in a case which was non
responsive to Convenia was to say the least dramatic and provides
an opportunity for the treatment of non-responsive cases in the
future. Not just did the treatments deal with infection, but they
brought this case from a pretty hopeless state to complete cure in
less than twenty one days.
[0627] The cream has shown, in clinical use, to be effective on
previously non responsive wounds and ulcerations. As shown in FIG.
32A, wound closure of a chronically infected festering open non
healing wound with failure to respond to multiple different
antibiotics including topical creams. The dog's owner consented to
the use of the dog's case record, so that other patients could
benefit in the way that the dog had. So impressed by the result of
the treatment was the dog owner that he not only consented to the
use of the initial case records, but he brought the dog back for
follow up photographs (see, e.g., FIG. 32B). One of dog owner's
more interesting comments was on how well the dog tolerated the
creams application to such a large open and obviously tender wound
as the initial bandaging and un-bandaging had obviously been so
painful. The dog has returned to completely normal activity and
unless one knew there had been a problem no one would know that the
dog had ever been injured.
[0628] The cream creates a protective barrier around the entire
wound. As shown in FIG. 33A, the wound healing of a very extensive
degloved injury to the skin on the back and sides of a greyhound
pictured only 24 hours after cream application. As shown in FIG.
33B, the patient had an uneventful recovery despite the degree of
degloving and the extent of the wound and the previous history of
the patient's wounds breaking down. The antibiotic cover was not
extended beyond the initial 5 days and no analgesic or
anti-inflammatory other than the HP Vet Cream was used.
[0629] The cream may be used in conjunction with conventional
antibiotic therapy to enhance effect. As shown in FIG. 34A, a dog
had hair loss, itching and a skin disorder. The owner was
administering triple antibiotic cream twice daily, baking soda
baths once a week and dipping in happy jack flea and tick dip. The
owner noticed the abrasions began to turn yellow and looked
infected. The owner was subsequently instructed to apply HP Healing
cream twice daily for 7-10 days. As shown in FIG. 34B, seven days
later, The owner noted that itching had ceased. The skin was much
improved and the hair had began to grow back in.
[0630] The non-steroidal cream also has non-stringent seals in
moisture. FIG. 35A depicts incorporation of HP Vet Cream in the
treatment of a septic compound fracture and accompanying wound.
FIG. 35B depicts the recovery in the case, which was dramatic
considering the initial prognosis. What was interesting with the
use of HP Vet Cream in this case was how its withdrawal resulted in
slower healing until it was reintroduced and also how it improved
hair growth around the wound
[0631] The cream acts as a barricade under which cell regeneration
can go unhindered and speed the closure and bridging of wounds. As
shown in FIG. 36A, a dog was presented for a laceration on right
side. The dog jumped off a fenced in area and caught herself on the
fence. The dog was treated with HP Healing Cream, applied twice
daily for 7 days. The dog was presented 7 days later for a re-check
on the laceration on the right side. Laceration was reduced in size
by half, as shown in FIG. 36B. The owner was instructed to continue
to apply HP Healing Cream another two weeks.
[0632] The cream can be used externally on open or bandaged wounds.
Liberal application is recommended under bandage. FIG. 37A depicts
the treatment of a simple slow healing wound with HP Vet Cream. The
patient was presented to the clinic three weeks after the initial
injury with an incised type wound that although small just would
not heal and this was in part the patients own fault as it objected
to normal forms of wound closure. As shown in FIG. 37B, Within two
days of starting the application of HP Vet Cream the wound had
started to heal and the owner reduced application of the cream to
once daily. The wound had healed completely within six days of
starting application of HP Vet Cream and the owner ceased applying
the cream at that stage with no further problems and this was
despite the fact that for the three previous weeks the wound had
steadfastly refused to heal.
[0633] The cream works in conjunction with the body's natural
healing mechanisms. As shown in FIG. 38A, accelerated wound closure
and healing without suturing of acute bite wounds compounded with
muscle laceration and severe deep and surface tissue bruising with
the use of HP Vet Cream. As shown in FIG. 38B, the rapidity of
healing is very clear when one looks at the state of the patient
where there is a total disappearance of tissue bruising and all
surface injuries other than the major wound points had literally
vanished. In a patient with no anti-inflammatory or analgesic
treatment one would not normally have expected the patient to be
fully mobile in two days.
[0634] An anti-infective and anti-inflammatory effect are naturally
provided. As shown in FIG. 39A, accelerated wound closure and
healing without suturing of acute bite wounds compounded with
muscle laceration and severe deep and surface tissue bruising with
the use of HP Vet Cream. As shown in FIG. 39B, just 9 days after
initial admital, the entire mammary hypertrophy had disappeared.
One can see from the indentations on the practice golf ball that
the cat was back to her initial kitten like self playing with
toys.
[0635] The cream is not listed for use in cases of eczema. As
depicted in FIG. 40A, there were lesions over the head, has hair
loss with crusting and wrinkling of the skin. The cream was
possibly being groomed off by kitten. As shown in FIG. 40B, the cat
was presented to clinic again one week later for no improvement
suggesting that the cream may not be suitable for cases of
eczema.
[0636] This example demonstrates that the cream seals in moisture,
an anti-infective, anti-inflammatory effect are naturally provided,
a healing effect is transferred over the entire wound, may be used
with conventional antibiotic therapy to enhance effect and is non
stringent. The cream acts as barricade under which cell
regeneration can go unhindered and speeds the closure and bridging
of wounds. The cream can be used externally on open or bandaged
wounds (liberal application is recommended under bandages). The
cream has been shown in clinical use to be effective on previously
non-responsive wounds and ulcerations. The cream also works in
conjunction with the body's natural healing mechanisms.
Example 26
Additional Human Studies
White Female: 60 Years Old
[0637] After no response from conventional treatment, including
antibiotics and Hyperbaric chamber (FIGS. 41A-B), client was placed
on the cream (FIGS. 41C-D). Improvement was visible after six weeks
(FIGS. 41D-E) and two months (FIG. 41F). She was able to attend a
wedding with open shoes.
Male with Ingrown Hair
[0638] A 33 year old male with an ingrown hair that had become a 6
month long treatment course. The wound was surgically treated to
attempt to bring the wound walls closer to attempt to support
healing. Pain medication along with conventional antibiotic
coverage and Hyberbaric chamber, repeated surgical wound
debridement and wound edge cleaning treatments over a one year
period along with alternating wet to moist compression bandaging
with no success.
[0639] In 6 weeks of treatment with the healing cream the wound has
progressed to closure and full healing (FIGS. 42A-C). The wound
centers doctors were so impressed with the patients response to the
cream that his case was presented as a poster at a wound healing
conference.
[0640] The invention is further described by the following numbered
paragraphs:
[0641] 1. An anti-infective homeopathic complex comprising a
homeopathic tincture or dilutions thereof of Hepar sulphuris
calcareum or other similar profiled Calcarea or Sulphur salt or
acid, Lachesis muta or other remedy with a similar profile,
Mercurius Solubilis or similar mercury containing remedy, and
Silica or other silica containing remedy.
[0642] 2. A homeopathic complex according to paragraph 1 wherein
Hepar Sulphuris calcareum is replaced or supplemented with Calc
Sulph or Calc Sil.
[0643] 3. A homeopathic complex according to paragraph 1 or
paragraph 2 wherein Lachesis muta is replaced or supplemented with
a snake or spider remedy with a similar septic shock profile,
preferably Crotalidae (Crotalus Horridalus), Pyrogen and/or
Tarentula Cubensis.
[0644] 4. A homeopathic complex according to any of paragraph 1 to
3 wherein Mercurius Solulbilis is replaced or supplemented with
Phytolacca decandra.
[0645] 5. A homeopathic complex according to any of the preceding
paragraphs in a potency range from mother tincture to 100M,
preferably from mother tincture to 50M.
[0646] 6. A homeopathic complex according to any of paragraphs 1 to
4 in LM potencies.
[0647] 7. A homeopathic complex according to any of the preceding
paragraphs comprising a homeopathic tincture or dilutions thereof
of the Ranunculacea family, preferably the Aconite or Aconitine,
more preferably Aconite napellus [Acon];
[0648] the Compositae family, preferably Arnica montana [Arn];
Bellis perennis [Bell-p]; Calendula Offcinalis [Calen]; Chamomilla
Matricaria [Cham]; Millefolium achillea [Mill]; Carduus Marianus;
and/or Echinacea, preferably Echinacea angustifolia [Echi];
Echinacea purpurea [Echi-p];
[0649] the Solanacea family, preferably Belladonna [Bell];
[0650] Arsenicum, preferably Arsenicum iodatum [Ars-i] and/or
Arsenicum Album;
[0651] Bryonia alba [Bry];
[0652] Hamamelis virginiana [Ham];
[0653] Hypericum Perforatum [Hyper];
[0654] Ledum palustre [Led];
[0655] Phytolacca decandra [Phyt];
[0656] the Anacardiacae family preferably Rhus Toxicodendron
[Rhus-T.];
[0657] the Rutaceae family preferably Ruta Graveolans [Ruta];
[0658] Stellaria media [Stel]; and/or
[0659] Symphytum officinale [Symph].
[0660] 8. A homeopathic complex according to any of the preceding
paragraphs comprising a homeopathic tincture or dilutions thereof
of
[0661] Aconite napellus [Acon]
[0662] Arnica montana [Arn];
[0663] Arsenicum iodatum [Ars-i];
[0664] Belladonna [Bell];
[0665] Bellis perennis [Bell-p];
[0666] Bryonia alba [Bry];
[0667] Calenula Offcinalis [Calen];
[0668] Echinacea angustifolia [Echi];
[0669] Echinacea purpurea [Echi-p];
[0670] Hamamelis virginiana [Ham];
[0671] Hypericum Perforatum [Hyper];
[0672] Ledum palustre [Led];
[0673] Millefolium achillea [Mill];
[0674] Phytolacca decandra [Phyt];
[0675] Rhus Toxicodendron [Rhus-T.];
[0676] Ruta Graveolans [Ruta]; and
[0677] Symphytum officinale [Symph].
[0678] 9. A homeopathic complex according to paragraph 7 or
paragraph 8 further comprising optional Core B ingredients Thuja
Occidentalis [Thuj], Chamomilla Matricaria [Cham], Stellaria media
[Stel] and/or Sulphur [Sulph].
[0679] 10. A homeopathic complex according to any of paragraphs 7
to 9 further comprising optional Core B ingredient Graphites
naturalis.
[0680] 11. A homeopathic complex according to any of paragraphs 7
to 10 further comprising Apis mellifica [Apis], Urtica urens
[Urt-u], and Unbelliferae preferably Conium maculatum and/or
Gunpowder.
[0681] 12. A homeopathic complex according to any of the preceding
paragraphs further comprising a homeopathic tincture or dilutions
thereof of
[0682] The Arsenicums, preferably Arsenicum album [Ars];
[0683] The Barytas and Cabonicums, preferably Baryta carbonica
[Bar-c] and/or Kali Carbonicum;
[0684] Carbo vegetabilis [Carb-v];
[0685] The Calcareas, preferably Calcarea carbonica [Calc];
Calcarea fluorica [Calc-f] and/or Calcarea phosphorica
[Calc-p];
[0686] Gelsemium sempervirens [Gels];
[0687] Iodium purum [Iod];
[0688] The Kalis, preferably Kali iodatum [Kali-i] and/or Kali
Carbonicum
[0689] Lacs, preferably Lac caninum [Lac-c]; Lac vaccinum and/or
Lac Vaccinum (cow);
[0690] Lycopodium clavatum [Lyc];
[0691] The Natrums and Muriatricums, preferably Natrum Mur
[0692] Nux vomica [Nux-v];
[0693] Phosphorus, preferably Phosphorus [Phos] and/or Ferrum
Phos;
[0694] the Ranunculacea family, preferably Pulsatilla nigricans
[Puls] and/or Staphysagria [Staph];
[0695] Sabal serrulata [Sabal];
[0696] Sepia succus [Sep]; and/or
[0697] Zincums preferably Zincum metallicum [Zinc].
[0698] Baptisia tinctoria;
[0699] Pyrogen;
[0700] Astragalus membranaceus;
[0701] Bufo rana; and/or
[0702] Ipecacuanha.
[0703] 13. A homeopathic complex according to paragraph 12 further
comprising Cantharis, Causticum, Crategus, Ferrum Phos and/or
Laurocerasus.
[0704] 14. A homeopathic complex according to any of the preceding
paragraphs further comprising a homeopathic tincture or dilutions
thereof of
[0705] Adrenalin [Adren];
[0706] Aesculus hippocastanum [Aesc];
[0707] Alfalfa;
[0708] Aurums;
[0709] The Antimoniums, preferably Antimonium Tart
[0710] Berberis Vulgaris;
[0711] Cactus Grandiflora;
[0712] Caladium seguinum [Calad];
[0713] Cantharis vesicatoria [Canth];
[0714] Carduus Marianus;
[0715] Cocculus indicus [Cocc];
[0716] Chelidonium;
[0717] China officinalis;
[0718] Chionanthus virginica;
[0719] Drosera rotundifolia;
[0720] Equisetum hyemale;
[0721] Euphrasia:
[0722] Galium Aprine;
[0723] Grindelia;
[0724] Histaminium (Histamine) [Hist];
[0725] Hydrastis canadensis [Hydr];
[0726] Lappa Articum;
[0727] Lavender [Lav-v.];
[0728] Lobelia inflata;
[0729] Mezereum [Mez];
[0730] Nitric acid [Nit-ac];
[0731] Paeonia Officinalis [Paeon];
[0732] Prednisolone [Predni.];
[0733] Ranunculus bulbosus [Ran-b];
[0734] Rumex crispus [Rumx];
[0735] Solidago virgaurea;
[0736] Strophantus hispidus;
[0737] Taraxacum officinale;
[0738] Triticum Repens;
[0739] The Stannums preferably Stannum Met;
[0740] Thiosinaminum [Thiosin];
[0741] Uva Ursi;
[0742] Veratrum Album;
[0743] Cuprum met; and/or
[0744] Sol [Sol].
[0745] 15. An anti-infective homeopathic complex comprising a
homeopathic tincture and dilutions thereof of the following
ingredients: Hepar Sulph; Lachesis; Merc; Sil; Aconite napellus;
Arnica montana; Arsenicum iodatum; Belladonna; Bellis perennis;
Bryonia alba; Calenula Offcinalis; Chamomilla Matricaria; Echinacea
angustifolia; Echinacea purpurea; Graphites naturalis; Hamamelis
virginiana; Hypericum Perforatum; Ledum palustre; Millefolium
achillea; Phytolacca decandra; Rhus Toxicodendron; Ruta Graveolans;
Stellaria media; Sulphur; Symphytum officinale; and Thuja
Occidentalis.
[0746] 16. An anti-infective homeopathic complex comprising a
homeopathic tincture and dilutions thereof of the following
ingredients: Aconitum Napellus; Arnica Montana; Arsenicum Iod;
Belladonna; Bellis Perenis; Bryonia Alba; Calenula Offcinalis;
Chamomilla Matricaria; Conium maculatum; Echinacia augustofolia;
Echinacia Purpurea; Graphites Gunpowder; Hamamellis Virginia; Hepar
Sulphuris; Hypericum Perforatum; Lachesis; Ledum; Millefolium;
Mercurius Solubilis; Phytolacca decandra; Ruta Graveolans; Rhus
Toxicodendron; Silica [Sil]; Stellaria Media; Sulphur; Symphytum;
Thuja Occidentalis; and Urtica Urens.
[0747] 17. An anti-infective homeopathic complex according to
paragraph 15 or paragraph 16 wherein the homeopathic ingredients
are provided in a potency range from Mother tincture to
18.times..
[0748] 18. An anti-infective homeopathic complex according to any
of paragraphs 15 to 17 in a form suitable for topical
administration.
[0749] 19. An anti-infective homeopathic complex comprising a
homeopathic tincture and dilutions thereof of the following
ingredients: Aconite; Apis; Arnica Montana; Arsencium Iod;
Belladonna; Bellis Perennis; Bryonia; Calendula; Cantharis; Carbo
Veg; Causticum; Conium; Crategus; Echinacea Augustifolia; Echinacea
Purpura; Ferrum Phos; Gelsemium; Hammamellis; Hepar Sulph;
Hypericum; Lachesis; Laurocerasus; Ledum; Merc Sol; Millefolium;
Nux Vomica; Phosphorus; Phytolacca; Rhus Tox; Ruta Gray; Silica;
Sulphur; Staphysagria; Symphytum; Urtica; Chamomilla matrica; and
Stellaria.
[0750] 20. An anti-infective homeopathic complex according to
paragraph 19 wherein the homeopathic ingredients are provided in a
potency range from 30 C and greater, preferably 200 C and greater
and LM potencies.
[0751] 21. An anti-infective homeopathic complex according
paragraph 19 or paragraph 20 in a form suitable for internal
administration.
[0752] 22. A homeopathic complex according to any of the preceding
paragraphs further comprising nosodes.
[0753] 23. A homeopathic complex as paragraphed in any of the
preceding paragraphs in a form adapted for topical delivery wherein
the ingredients are present at a potency range from Mother Tincture
to 30 c, preferably from Mother Tincture to 12 c, more preferably
from Mother Tincture to 9 c, even more preferably from mother
tincture to 30.times..
[0754] 24. A homeopathic as paragraphed paragraph 23 in the form of
a liquid, cream, lotion, gel or in a form adapted for
administration in a dressing or bandage.
[0755] 25. A homeopathic complex as paragraphed in any of the
preceding paragraphs in a form adapted for internal delivery
wherein the core ingredients are present at a potency range from 1
C to 100M, preferably 12 C to 1M, more preferably from 30 C to 1M,
more preferably from 200 C to 1M, even more preferably 1M to 10M
and including LM potencies.
[0756] 26. A homeopathic as paragraphed paragraph 25 in the form of
an oral tablet, pill, pillule, gel cap, spray and/or drop.
[0757] 27. A homeopathic complex as paragraphed in any of the
preceding paragraphs further comprising conventional pharmaceutical
excipients and/or carriers.
[0758] 28. A combination therapy comprising the homeopathic complex
as paragraphed in any of the preceding paragraphs and a
conventional pharmaceutical.
[0759] 29. A combination therapy according to paragraph 28 wherein
the conventional pharmaceutical is an orally administered
antibiotic or topically administered antibiotic.
[0760] 30. A homeopathic complex as paragraphed in any of the
preceding paragraphs for use in therapy.
[0761] 31. A homeopathic complex as paragraphed in any of the
preceding paragraphs for use in the treatment or prophylaxis of
infection as an anti-infective agent, preferably in the treatment,
control or prophylaxis of MRSA or other multi-resistant microbial
strains.
[0762] 32. A homeopathic complex as paragraphed in any of the
preceding paragraphs for use in the regeneration of diseased or
damaged tissue.
[0763] 33. A homeopathic complex as paragraphed in paragraph 16 for
use in the treatment of mastitis.
[0764] 34. A homeopathic complex as paragraphed in paragraph 19 for
use as a first aid remedy.
[0765] 35. A homeopathic complex as paragraphed in any of the
preceding paragraphs for use in the treatment of humans and
animals, including canines, equines, porcine and/or felines.
[0766] 36. A method for the manufacture of a medicament comprising
a homeopathic complex as paragraphed in any of paragraphs 1 to 27
for use in the treatment or prophylaxis of infection and/or the
regeneration of diseased or damaged tissue.
[0767] 37. A method for the treatment or prophylaxis of infection
and/or the regeneration of diseased or damaged tissue in a subject
comprising the steps of administering an effective amount of a
homeopathic complex as paragraphed in any of paragraphs 1 to 27 to
a patient in need of such treatment.
[0768] 38. A cosmetic preparation comprising a homeopathic complex
as paragraphed in any of paragraphs 1 to 27 and a suitable cosmetic
carrier.
[0769] Having thus described in detail preferred embodiments of the
present invention, it is to be understood that the invention
defined by the above paragraphs is not to be limited to particular
details set forth in the above description as many apparent
variations thereof are possible without departing from the spirit
or scope of the present invention.
* * * * *
References