U.S. patent application number 12/781070 was filed with the patent office on 2010-12-09 for methods and devices for the detection of hypopnoea.
This patent application is currently assigned to RESMED LIMITED. Invention is credited to Jeffrey Peter Armitstead.
Application Number | 20100307500 12/781070 |
Document ID | / |
Family ID | 42937117 |
Filed Date | 2010-12-09 |
United States Patent
Application |
20100307500 |
Kind Code |
A1 |
Armitstead; Jeffrey Peter |
December 9, 2010 |
METHODS AND DEVICES FOR THE DETECTION OF HYPOPNOEA
Abstract
Automated methods provide hypopnea detection for determining a
hypopnea event and/or a severity of a hypopnea event. In some
embodiments, a calculated short-term variance of a measured
respiratory flow signal are compared to first and second
proportions of a calculated long-term variance of the measured flow
signal. A detection of the hypopnea may be indicated if the first
measure falls below and does not exceed a range of the first and
second proportions during a first time period. In some embodiments,
a hypopnea severity measure is determined by automated measuring of
an area bounded by first and second crossings of a short-term
measure of ventilation and a proportion of a long-term measure. The
detection methodologies may be implemented for data analysis by a
specific purpose computer, a detection device that measures a
respiratory airflow or a respiratory treatment apparatus that
provides a respiratory treatment regime based on the detected
hypopneas.
Inventors: |
Armitstead; Jeffrey Peter;
(North Sydney, AU) |
Correspondence
Address: |
LERNER, DAVID, LITTENBERG,;KRUMHOLZ & MENTLIK
600 SOUTH AVENUE WEST
WESTFIELD
NJ
07090
US
|
Assignee: |
RESMED LIMITED
Bella Vista
AU
|
Family ID: |
42937117 |
Appl. No.: |
12/781070 |
Filed: |
May 17, 2010 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
61184592 |
Jun 5, 2009 |
|
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|
Current U.S.
Class: |
128/204.23 |
Current CPC
Class: |
A61M 16/0875 20130101;
A61B 5/7278 20130101; A61M 16/0069 20140204; A61B 5/725 20130101;
A61M 16/0666 20130101; A61M 2230/205 20130101; A61B 5/087 20130101;
A61M 16/024 20170801; A61M 2016/0039 20130101; A61M 2205/3334
20130101; A61B 5/7282 20130101; A61B 5/4818 20130101; A61M 2230/40
20130101; A61M 2016/003 20130101; A61M 16/0003 20140204; A61M
2205/505 20130101; A61M 2230/205 20130101; A61M 2230/005
20130101 |
Class at
Publication: |
128/204.23 |
International
Class: |
A61M 16/00 20060101
A61M016/00 |
Claims
1. A hypopnea detection apparatus comprising: a controller having
at least one processor to access data representing a measured flow
of breathable gas, the controller being further configured to:
determine a first measure from a short-term variance of the data;
determine a second measure from a long-term variance of the data;
compare the first measure with first and second proportions of the
second measure; and indicate a detection of the hypopnea based on
the comparing if the first measure falls below the first proportion
and does not subsequently exceed a range of the first and second
proportions during a first time period.
2. The apparatus of claim 1 wherein the first proportion is less
than the second proportion and wherein the controller is further
configured to indicate a detection of a hypopnea if the first
measure does not exceed the first proportion during the first time
period.
3. The apparatus of claim 1 wherein the first proportion is less
than the second proportion and wherein the controller is further
configured to indicate a detection of a hypopnea if the first
measure exceeds the first proportion but does not exceed the second
proportion during the first time period.
4. The apparatus of claim 1 wherein the controller is further
configured to detect a measure of flow limitation from the data and
wherein the indicating the detection of the hypopnea is further
based on the measure of flow limitation being indicative of
obstruction.
5. The apparatus of claim 1 wherein the comparing of the first
measure and the first proportion represents a determination of
whether an RMS value calculated from approximately ten to fifteen
seconds of respiratory flow data falls below a threshold of
approximately fifty percent of an RMS value calculated from
approximately fifty to seventy seconds of respiratory flow data and
wherein the first period of time is approximately three to eight
seconds.
6. The apparatus of claim 1 wherein the comparing of the second
measure and the second proportion represents a determination of
whether an RMS value calculated from approximately ten to fifteen
seconds of respiratory flow data is below a threshold of
approximately seventy five percent of an RMS value calculated from
approximately fifty to seventy seconds of respiratory flow
data.
7. The apparatus of claim 6 wherein the comparing of the first
measure and the first proportion represents a determination of
whether an RMS value calculated from approximately ten to fifteen
seconds of respiratory flow data falls below a threshold of
approximately fifty percent of an RMS value calculated from
approximately fifty to seventy seconds of respiratory flow data and
wherein the first period of time is approximately three to eight
seconds.
8. The apparatus of claim 1 wherein the controller is further
configured to impede a further detection of a hypopnea until the
first measure exceeds the second proportion during a second period
of time.
9. The apparatus of claim 8 wherein the impeding of the further
detection comprises comparing of the first measure and the second
proportion, wherein this comparing represents a determination of
whether an RMS value calculated from approximately ten to fifteen
seconds of respiratory flow data exceeds a threshold of
approximately seventy five percent of an RMS value calculated from
approximately fifty to seventy seconds of respiratory flow data and
wherein the second period of time is approximately ten to twenty
seconds.
10. The apparatus of claim 1 further comprising a flow sensor and
wherein the controller is further configured to determine the
measured flow of breathable gas with the flow sensor.
11. The apparatus of claim 10 further comprising: a flow generator
configured to produce a breathable gas for a patient at a pressure
above atmospheric pressure; wherein the controller is further
configured to control the flow generator to produce the breathable
gas according to a pressure therapy regime based on the detected
hypopnea.
12. An apparatus to detect a hypopnea from a measured flow of
breathable gas, the apparatus comprising: a controller having at
least one processor to access data representing a measured flow of
breathable gas, the controller being further configured to:
determine a long-term measure of ventilation from the measured
flow; determine a short-term measure of ventilation from the
measured flow; determine a threshold as a proportion of the
long-term measure of ventilation; measure an area bounded by first
and second crossings of the short-term measure of ventilation and
the threshold; and detect the hypopnea with the measured area.
13. The apparatus of claim 12 wherein the controller is configured
to measure the area by integrating a difference between the
threshold and the short-term measure of ventilation during a time
period from when the short-term measure falls below the threshold
to when the short-term measure exceeds the threshold.
14. The apparatus of claim 12 wherein the controller is configured
to measure the area by adding a plurality of sample differences
during a time period from when the short-term measure falls below
the threshold to when the short-term measure exceeds the threshold,
wherein each sample difference is a difference between a sample of
the threshold and a sample of the short-term measure of
ventilation.
15. The apparatus of claim 12 wherein the controller is further
configured to impede a further detection of a hypopnea during a
refractory period initiated by detection of the second
crossing.
16. The apparatus of claim 12 wherein the controller is further
configured to trigger the measuring of the area upon detecting the
first crossing by comparing the short-term measure of ventilation
and the threshold for inequality.
17. The apparatus of claim 16 wherein the detection of the hypopnea
is contingent upon a time from the first crossing to the second
crossing exceeding about ten seconds.
18. The apparatus of claim 12 wherein the short-term measure of
ventilation comprises an output of low pass filtering half of an
absolute value of a measure of flow of breathable gas with a first
time constant.
19. The apparatus of claim 18 wherein the long-term measure of
ventilation comprises an output of low pass filtering half of an
absolute value of a measure of flow of breathable gas with a second
time constant, the second time constant being larger than the first
time constant.
20. The apparatus of claim 19 wherein the proportion comprises
approximately seventy percent.
21. The apparatus of claim 12 wherein the controller is further
configured to indicate a severity of the hypopnea with the measure
of area.
22. The apparatus of claim 12 wherein the detecting comprises
comparing the measured area with a threshold chosen to be
approximately indicative of a desaturation of blood oxygen of at
least four percent.
23. The apparatus of claim 11 wherein the controller is further
configured to detect a measure of flow limitation from the data and
wherein the detection of the hypopnea is further based on the
measure of flow limitation being indicative of obstruction.
24. The apparatus of claim 12 further comprising a flow sensor and
wherein the controller is further configured to determine the
measured flow of breathable gas with the flow sensor.
25. The apparatus of claim 24 further comprising: a flow generator
configured to produce a breathable gas for a patient at a pressure
above atmospheric pressure; wherein the controller is further
configured to control the flow generator to produce the breathable
gas according to a pressure therapy regime based on the detected
hypopnea.
26. An apparatus to detect a hypopnea from a measured flow of
breathable gas, the apparatus comprising: a controller having at
least one processor to access data representing a measured flow of
breathable gas, the controller being further configured to:
determine a long-term measure of ventilation from the data;
determine a short-term measure of ventilation from the data;
determine a threshold as a proportion of the long-term measure of
ventilation; calculate an extent of a hypopnea as a function of the
short-term measure of ventilation and the threshold; and indicate a
severity of the hypopnea with the calculated extent.
27. The apparatus of claim 26 wherein the controller is configured
to indicate the severity by outputting a value of the calculated
extent to an output device.
28. The apparatus of claim 27 wherein the controller calculates the
extent by calculating an area bounded by first and second crossings
of the short-term measure of ventilation and the threshold.
29. The apparatus of claim 28 wherein the controller is further
configured to compare the calculated area with a threshold chosen
to be approximately indicative of a desaturation of blood oxygen of
at least four percent.
30. The apparatus of claim 26 further comprising a flow sensor and
wherein the controller is further configured to determine the
measured flow of breathable gas with the flow sensor.
31. The apparatus of claim 30 further comprising: a flow generator
configured to produce a breathable gas for a patient at a pressure
above atmospheric pressure; wherein the controller is further
configured to control the flow generator to produce the breathable
gas according to a pressure therapy regime based on the detected
hypopnea.
32. The apparatus of claim 31 wherein the controller is further
configured to detect a measure of flow limitation from the data and
wherein the indicating the detection of the hypopnea is further
based on the measure of flow limitation being indicative of
obstruction.
33. A hypopnea detection apparatus comprising: a controller having
at least one processor to access data representing a measured flow
of breathable gas, the controller being further configured to
control: a detection of an hypopnea event from the data
representing the measured flow of breathable gas; a determination
of a measure indicative of obstruction coincident with the hypopnea
event in the data representing the measured flow; and a
classification the detected hypopnea event as obstructive or
central based on the determining of the measure indicative of
obstruction.
34. The apparatus of claim 33 wherein the determination detects
partial obstruction and the classification comprises scoring an
obstructive hypopnea event.
35. The apparatus of claim 34 wherein the controller is further
configured to control a detection of an absence of a breath and the
classification comprises scoring a central hypopnea event.
36. The apparatus of claim 34 wherein the controller is further
configured to detect an absence of a breath coincident with a
further detected hypopnea event and to refrain from scoring the
further detected hypopnea event based on the detected absence of a
breath.
37. The apparatus of claim 32 further comprising: a flow generator
configured to produce a breathable gas for a patient at a pressure
above atmospheric pressure; and a flow sensor, wherein the
controller is further configured to measure the flow of breathable
gas with the flow sensor and to control the flow generator to
produce the breathable gas according to a pressure therapy regime
based on the detected hypopnea.
Description
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of the filing date of
U.S. Provisional Patent Application No. 61/184,592 filed Jun. 5,
2009, the disclosure of which is hereby incorporated herein by
reference.
FIELD OF THE TECHNOLOGY
[0002] The present technology relates to methods and apparatus for
detection of hypopnea.
BACKGROUND OF THE TECHNOLOGY
[0003] Patients with OSA have recurrent apnoeas or hypopnoeas
during sleep that are only terminated by the patient arousing. A
hypopnea may be considered a partial reduction in breathing that
lasts at least 10 seconds during sleep. The 1999 American Academy
of Sleep Medicine (AASM) guidelines specify a hypopnea condition as
a 10 second reduction in flow of 50% or more or a reduction of flow
of less than 50% followed by an arousal or a desaturation of at
least 3%. Subsequent AASM guidelines specify a 30% reduction in
ventilation and a desaturation of at least 4% as a hypopnea
condition. These recurrent events cause sleep fragmentation and
stimulation of the sympathetic nervous system. This can have severe
consequences for the patient including day-time sleepiness (with
the attendant possibility of motor-vehicle accidents), poor
mentation, memory problems, depression and hypertension. Patients
with OSA are also likely to snore loudly, thus also disturbing
their partner's sleep.
[0004] The best form of treatment for patients with OSA is constant
positive airway pressure (CPAP) applied by a blower (compressor)
via a connecting hose and mask. The positive pressure prevents
collapse of the patient's airway during inspiration, thus
preventing recurrent apnoeas or hypopnoeas and their sequelae. Such
a respiratory treatment apparatus can function to supply the
patient with a supply of clean breathable gas (usually air, with or
without supplemental oxygen) at the therapeutic pressure or
pressures, at appropriate times during the subject's breathing
cycle.
[0005] Respiratory treatment apparatus typically include a flow
generator, an air filter, a mask or cannula, an air delivery
conduit connecting the flow generator to the mask, various sensors
and a microprocessor-based controller. The flow generator may
include a servo-controlled motor and an impeller. The flow
generator may also include a valve capable of discharging air to
atmosphere as a means for altering the pressure delivered to the
patient as an alternative to motor speed control. The sensors
measure, amongst other things, motor speed, gas volumetric flow
rate and outlet pressure, such as with a pressure transducer, flow
sensor or the like. The apparatus may optionally include a
humidifier and/or heater elements in the path of the air delivery
circuit. The controller may include data storage capacity with or
without integrated data retrieval/transfer and display
functions.
[0006] To treat hypopnea, automated apparatus have been implemented
with algorithms to detect a hypopnea condition based on data from a
flow sensor. Examples of conventional apnea/hypopnea detection
devices are taught in U.S. Pat. No. 5,295,490 to Dodakian; U.S.
Pat. No. 5,605,151 to Lynn; U.S. Pat. No. 5,797,852 to Karakasoglu
et al.; U.S. Pat. No. 5,961,447 to Raviv et al.; U.S. Pat. No.
6,142,950 to Allen et al.; U.S. Pat. No. 6,165,133 to Rapoport et
al.; U.S. Pat. No. 6,368,287 to Hadas; U.S. Pat. No. 7,118,536 to
Haberland et al. For example, in one such device, a hypopnoea can
be deemed detected if a 10 or 12 second root mean square (RMS) of a
flow (in L/sec) signal drops below 1.2 times the long-term average
minute ventilation (in L/sec) (e.g., low pass filtering the
absolute value of a flow signal divided in half), which
approximately corresponds to a reduction to 50% of the normal RMS
ventilation. A 50% reduction of an RMS ventilation may also be
detected by comparing a ten second variance of a flow signal
calculated over a 10 second window with the product of (0.5).sup.2
and a sixty second variance of a flow signal calculated over a 60
second window. Such devices may also include a refractory period of
time after detecting a hypopnea to prevent multiple scoring of a
common hypopnea event. For example, the device may remain
refractory for 15 seconds or until the RMS ventilation returns to
at least three quarters of a long-term RMS ventilation for 15
contiguous seconds.
[0007] However, the question of the presence of a hypopnea
condition itself is subject to interpretation. There is often
considerable clinician variability in scoring the presence of a
hypopnea. Thus, while automated apparatus may be implemented with
various methods to detect the condition, differences in the
implemented detection criteria can result in different hypopnea
scoring for common breathing events.
[0008] It may be desirable to develop further methods for detecting
hypopnea which may also be implemented in apparatus for detection
and apparatus for treating upper respiratory conditions.
SUMMARY OF THE TECHNOLOGY
[0009] A first aspect of some embodiments of the present technology
is to provide methods and devices for detecting a hypoponea and/or
a severity of a hypopnea.
[0010] Another aspect of some embodiments of the technology is to
detect hypopneas or hypopnea severity in an apparatus that measures
a respiratory flow signal of a patient.
[0011] A still further aspect of the technology is to implement the
detection of hypopnea or hypopnea severity in a respiratory
treatment apparatus, such as a continuous positive airway pressure
device, based on or as a function of the detected hypopneas or
hypopnea severity.
[0012] Some embodiments of the present technology involve an
apparatus or controller with a method for controlling a processor
to detect a hypopnea from a measured flow of breathable gas. The
method of the controller or processor may involve determining a
first measure from a short-term variance of data based on a
measured flow of breathable gas. It may further involve determining
a second measure from a long-term variance of data based on a
measured flow of breathable gas. The first measure may be compared
with first and second proportions of the second measure. With the
method, the apparatus or controller may indicate a detection of the
hypopnea based on the comparing if the first measure falls below
the first proportion and does not subsequently exceed a range of
the first and second proportions during a first time period.
[0013] In some embodiments, the first proportion may be less than
the second proportion and the method may also involve indicating a
detection of a hypopnea if the first measure does not exceed the
first proportion during the first time period. Moreover, the method
may also involve indicating a detection of a hypopnea if the first
measure exceeds the first proportion but does not exceed the second
proportion during the first time period. In some embodiments, the
comparing of the first measure and the first proportion represents
a determination of whether an RMS value calculated from
approximately ten to twenty seconds, but preferably twelve seconds,
of respiratory flow data falls below a threshold of approximately
fifty percent of an RMS value calculated from approximately fifty
to seventy seconds, but preferably sixty seconds, of respiratory
flow data and wherein the first period of time is approximately
three to eight seconds, but preferably four seconds. Moreover, the
comparing of the second measure and the second proportion may
represent a determination of whether an RMS value calculated from
approximately ten to fifteen seconds, but preferably twelve
seconds, of respiratory flow data is below a threshold of
approximately seventy five percent of an RMS value calculated from
approximately fifty to seventy seconds, but preferably sixty
seconds, of respiratory flow data.
[0014] Optionally, further detections of a hypopnea may be impeded
until the first measure exceeds the second proportion during a
second period of time. This impeding of a further detection may
involve comparing of the first measure and the second proportion
such that the comparing represents a determination of whether an
RMS value calculated from approximately ten to fifteen seconds, but
preferably twelve seconds, of respiratory flow data exceeds a
threshold of approximately seventy five percent of an RMS value
calculated from approximately fifty to seventy seconds, but
preferably sixty seconds, of respiratory flow data and wherein the
second period of time is approximately ten to twenty seconds but
preferably fifteen, seconds. In some cases, the time from which the
long term measure of ventilation is calculated may be at least
approximately three to five times that of the time from which the
short term measure is calculated.
[0015] Some embodiments of the present technology involve an
apparatus or controller with a method for controlling a processor
to detect a hypopnea from a measured flow of breathable gas. The
method of the processor or controller may include determining a
long-term measure of ventilation and a short-term measure of
ventilation. The method of the processor or controller may further
include determining a threshold as a proportion of the long-term
measure of ventilation and measuring an area bounded by first and
second crossings of the short-term measure of ventilation and the
threshold. A hypopnea is then detected with the measured area. The
measuring may involve integrating a difference between the
threshold and the short-term measure of ventilation during a time
period from when the short-term measure falls below the threshold
to when the short-term measure exceeds the threshold. In some
embodiments, the measuring comprises adding a plurality of sample
differences during a time period from when the short-term measure
falls below the threshold to when the short-term measure exceeds
the threshold. Each sample difference may be a difference between a
sample of the threshold and a sample of the short-term measure of
ventilation.
[0016] Optionally, the method of the apparatus or controller may be
configured to impede a further detection of a hypopnea during a
refractory period initiated at the second crossing. Moreover, the
method may include triggering the measuring of the area upon
detecting the first crossing by comparing the short-term measure of
ventilation and the threshold for inequality. Still further, the
detecting of the hypopnea may be contingent upon a time from the
first crossing to the second crossing exceeding about ten seconds.
In some embodiments, the short-term measure of ventilation may be
an output of low pass filtering half of an absolute value of a
measure of flow of breathable gas with a first time constant.
Similarly, the long-term measure of ventilation may be an output of
low pass filtering half of an absolute value of a measure of flow
of breathable gas with a second time constant larger than the first
time constant. Optionally, the proportion may be set at
approximately seventy percent. In some embodiments, the device or
apparatus may indicate a severity of the hypopnea with the measure
of area. Optionally, the device or apparatus may compare the
measured area with a threshold chosen to be approximately
indicative of a desaturation of blood oxygen of at least four
percent.
[0017] Some embodiments of the present technology involve an
apparatus or controller with a method for controlling a processor
to detect a hypopnea from a measured flow of breathable gas that
includes the controller or a processor determining a long-term
measure of ventilation and a short-term measure of ventilation. A
threshold is then determined as a proportion of the long-term
measure of ventilation. The controller or processor then calculates
an extent of a hypopnea as a function of the short-term measure of
ventilation and the threshold. The apparatus then indicates a
severity of the hypopnea with the measured extent, which may
involve outputting a value of the measured extent. The calculated
extent may be a calculated area bounded by first and second
crossings of the short-term measure of ventilation and the
threshold. The calculated area may then optionally be compared with
a threshold chosen to be approximately indicative of a desaturation
of blood oxygen of at least four percent.
[0018] In some embodiments, the method of the apparatus or
controller may further detect a measure of flow limitation from a
measured flow of breathable gas and wherein the indicating the
detection of the hypopnea is further based on the measure of flow
limitation being indicative of obstruction.
[0019] Still further embodiments of the technology may involve a
methodology for controlling a processor to classify a hypopnea from
a measured flow of breathable gas. The method of the processor may
include detecting an hypopnea event from a measured flow of
breathable gas. It may further include determining a measure
indicative of obstruction in the measured flow coincident with the
hypopnea event. The method may also include classifying the
detected hypopnea event as obstructive or central based on the
determining of the measure indicative of obstruction. In some such
embodiments, the determining comprises detecting partial
obstruction and the classifying comprises scoring an obstructive
hypopnea event. In some such embodiments, the method may also
involve detecting an absence of a breath and the classifying may
involve scoring a central hypopnea event based on the absence of a
breath. In an alternative embodiment, the method may also involve
detecting an absence of a breath coincident with a detected
hypopnea event and refraining from scoring the detected hypopnea
event as either central hypopnea or obstructive hypopnea based on
the absence of the breath. In such a case, the event may be
considered to be an apnea.
[0020] In some embodiments, the technology may be implemented as a
hypopnea detection apparatus. In such an apparatus, an included
controller may have at least one processor to access data
representing a measured flow of breathable gas. The controller may
be configured to control a detection of an hypopnea event from the
data representing the measured flow of breathable gas. It may also
be configured to control a determination of a measure indicative of
obstruction coincident with the hypopnea event in the data
representing the measured flow. It may also be configured to
control a classification of the detected hypopnea event as
obstructive or central based on the determining of the measure
indicative of obstruction. In some such embodiments, the
classification detects partial obstruction and the classification
comprises scoring an obstructive hypopnea event. In some such
embodiments, the controller may be further configured to control a
detection of an absence of a breath and the classification may
involve scoring a central hypopnea event. In an alternative
embodiment, the controller may determine an absence of a breath
coincident with a detected hypopnea event and refrain from scoring
the event as either central hypopnea or obstructive hypopnea based
on the detected absence of the breath. In such a case, the event
may be considered to be an apnea. Such an apparatus may also
include a flow generator configured to produce a breathable gas for
a patient at a pressure above atmospheric pressure and a flow
sensor. The controller may then be configured to measure the flow
of breathable gas with the flow sensor and to control the flow
generator to produce the breathable gas according to a pressure
therapy regime based on the detected hypopnea.
[0021] Additional features of the present respiratory technology
will be apparent from a review of the following detailed
discussion, drawings and claims.
BRIEF DESCRIPTION OF DRAWINGS
[0022] The present technology is illustrated by way of example, and
not by way of limitation, in the figures of the accompanying
drawings, in which like reference numerals refer to similar
elements including:
[0023] FIG. 1 shows an example hypopnea detection apparatus of the
present technology with an optional flow sensor and flow
generator;
[0024] FIG. 2 is a flow diagram of an example embodiment of a
method of controlling an apparatus to detect a hypopnea;
[0025] FIG. 3 is a state diagram of a further example apparatus
that may implement a method of detecting a hypopnea;
[0026] FIG. 4 is a graph illustrating a detection correlation of an
example embodiment of the methodologies of the present
technology;
[0027] FIG. 5 is a further flow diagram of another example
embodiment of a method of controlling an apparatus to detect a
hypopnea and/or hypopnea severity;
[0028] FIG. 6 is an illustration of a graph of a measure for
detecting hypopnea and/or measuring an hypopnea severity; and
[0029] FIG. 7 is a block diagram of a controller in a hypopnea
detection apparatus including example components thereof suitable
for implementing the detection methodologies of the present
technology.
DETAILED DESCRIPTION
[0030] As illustrated in FIG. 1, embodiments of the present
technology may include a hypopnea detection device or apparatus
having a controller 104 that may have one or more processors to
implement particular hypopnea detection methodologies such as the
algorithms described in more detail herein. Thus, the device or
apparatus may include integrated chips, a memory and/or other
control instruction, data or information storage medium. For
example, programmed instructions encompassing such detection
methodologies may be coded on integrated chips in the memory of the
device or apparatus to form an application specific integrated chip
(ASIC). Such instructions may also or alternatively be loaded as
software or firmware using an appropriate data storage medium. With
such a controller or processor, the device can be used for
processing data from a flow signal. Thus, the processor may control
the assessment of a hypopnea occurrence or severity as described in
the embodiments discussed in more detail herein based on measured
and recorded respiratory flow data from a prior sleep session.
Alternatively, the detection may be performed during a sleep
session contemporaneously with the measuring of a respiratory flow
signal. Thus, in some embodiments, the device or apparatus itself
may optionally be implemented with a flow sensor 106 for measuring
a respiratory flow signal for use with the implemented
methodologies. For example, flow to or through a nasal cannula 108
or mask may be measured using a pneumotachograph and differential
pressure transducer or similar device such as one employing a
bundle of tubes or ducts to derive a flow signal. Optionally, a
flow signal may be inferred from other sensors, such as, a motor
current sensor as described in PCT/AU2005/001688 filed on Nov. 2,
2005, and U.S. patent application Ser. No. 12/294,957, the National
Stage thereof, the entire disclosures of which is incorporated
herein by cross reference.
[0031] By way of further example, the hypopnea detection device may
be implemented with a control methodology to respond to detected
hypopnea as a respiratory treatment apparatus. For example, as
illustrated in FIG. 1, detection device may be optionally
implemented with a flow generator such as a servo controlled blower
with suitable sensors for such control (e.g., a pressure sensor). A
respiratory treatment or pressure therapy regime, such as a
therapeutic pressure level associated with CPAP treatment, may be
delivered by the controller of the device. Such therapeutic
pressure levels may be automatically adjusted in response to the
detection of hypopnea conditions as described herein. For example,
pressure levels may be increased by a specified amount upon
detection of a hypopnea. Optionally, it may be increased
proportionally as a function of a detected hypopnea severity. For
example, a hypopnea with a greater severity measure may yield a
greater pressure adjustment then a hypopnea with a lesser severity
measure. Other pressure adjustment schemes may also be
implemented.
[0032] In some embodiments, the hypopnea detector may implement a
detection of a hypopnea according to AASM guidelines. For example,
the detector may be constructed to score a hypopnea event upon
detection of a reduction in ventilation by about 30% or more for
about 10 seconds or more coupled with the detection of a
desaturation of blood oxygen by about 4% or more. In such an
embodiment, the reduction in ventilation may, for example, be
determined by a measure of ventilation such as a tidal volume or
other such measure based on the measured respiratory flow signal.
Optionally, the measure of ventilation may be derived by processing
of determined breath peak inspiratory and/or breath peak expiratory
flows. Similarly, the reduction of blood oxygen may be based on
data from an oximetry signal from an optional oximetry sensor (not
shown in FIG. 1). However, as discussed in more detail herein,
other embodiments of the present technology may be implemented to
emulate such an AASM guideline without analysis of oximetry data
from an oximetry sensor.
[0033] (1) Example Detection Features
[0034] As illustrated in the flow chart of FIG. 2, in some
embodiments of the present technology an automated detection of a
hypopnea condition by a detection device may be based on the
determination or calculation of a variance from data representing a
measure of a flow of breathable gas or a respiratory flow signal.
For example, at 220 a first measure from a short-term variance
calculation may be determined. One such measure may be calculated
by determining the mean of the squares minus the square of the mean
of the samples from a respiratory flow signal from a flow sensor or
recorded data based thereon. Other methods for calculating the
variance may also be implemented. The short-term variance may be on
the order of seconds, such as about ten to fifteen seconds, for
example a 10 second variance utilizing about ten seconds of samples
taken from the flow signal. Similarly, a long-term variance measure
may be determined at 222. The long-term variance may be on the
order of minutes such as approximately one minute or about fifty to
seventy seconds, for example, 60 seconds utilizing about sixty
seconds of samples taken from the flow signal. In some cases, the
time from which the long term measure of ventilation is calculated
may be at least approximately three to five times that of the time
from which the short term measure is calculated. For example, is
the long term measure of ventilation is chosen to be calculated
from sixty seconds, the short term measure may be calculated as one
fifth (e.g., 60/5) to give a time period of twelve seconds.
[0035] At 224, a measure of the short-term variance may be compared
with first and second proportions of the long-term variance. For
example, it may be desired to detect a hypopnea based on a decrease
that does not exceed a certain range, for example, between of 45%
and 70%. In such a case, the long-term variance may be multiplied
by factors of (0.45).sup.2 and (0.7).sup.2. Optionally, these
factors may be utilized without the squaring operations if they are
multiplied by the square root of the long-term variance and the
resulting proportions are compared with the square root of the
short-term measure of variance. Such a comparison represents a
determination of a reduction in airflow based on RMS ventilation.
At 226, a hypopnea event may then be scored or indicated when the
measure of the short-term variance falls below the first proportion
but does not subsequently exceed a range of the first and the
second proportions for a period of time. Such a system may permit
more accurate automated detection or scoring of hypopnea, by
permitting brief excursions of data of the respiratory flow signal
above the first proportion but not the second while a time period
of the fall in patient breathing is accumulated or timed.
[0036] A state diagram for implementing such an embodiment of the
technology in a detector is illustrated in FIG. 3. The detector may
be useful for a device that contemporaneously scores hypopnea
during a sleep session with the detector while a patient is
experiencing the event but it may also be implemented for
post-session analysis. The behavior of the device begins at a start
state S0. At 332, the device may determine whether the RMS
ventilation falls below about a 50% threshold. For example, the
device may compare a short-term variance of a respiratory flow
signal determined over a 10 or 12 second data window (i.e.,
V.sub.10 or V.sub.12) with a proportion of a long-term variance
determined over a sixty second data window (e.g., (0.5).sup.2 times
V.sub.60). If this threshold is met or breached, a timing period
may be triggered or started at 334 and the device enters a sub-50
state (S1). For example, a count down timer (designated "Sub-50
Timer") may be set to a maximum period of about three to eight
seconds, but preferably four seconds. Other values for this time
setting may be pre-determined depending on the desired results of
hypopnea evaluation criteria. If the threshold is not met at 332,
the device returns to the start state (S0).
[0037] At 336, the device then determines whether the RMS
ventilation remains below about 50%. Such a test may be comparable
to the test implemented at 332. If not, then the device transitions
to an excursion range state (S2). From this state, the device tests
whether the RMS ventilation again falls below about 50% at 338. If
it does, the device then returns to the sub-50 state (S1). If not,
then the device tests whether the RMS ventilation exceeds about a
75% threshold at 340. For example, the device may compare the
short-term variance of a respiratory flow signal determined over a
10 or 12 second data window (i.e., V.sub.10 or V.sub.12) with
another proportion of the long-term variance determined over a
sixty second data window (e.g., (0.75).sup.2 times V.sub.60). If
this threshold is met or breached, then the device may transition
to the start state (S01) without scoring a hypopnea event. If at
340 the threshold is not met, then the device returns to the
excursion range state (S2).
[0038] If at 336 the test determines that the RMS ventilation
remains below about 50%, then the Sub-50 Timer is decremented or
permitted to count down if it has not expired (e.g., if it greater
than 0) at process block 342. Then, at 344, the Sub-50 Timer is
checked for an expiration condition such that the timing period has
expired or lapsed. If it has not expired the device remains in the
sub-50 state (S1). If it has expired, the device scores a hypopnea
upon entering the scored state (S3). Thus, detection device
indicates a hypopnea condition based on the analysis of the sub-50
state (S1) and the excursion range state (S2).
[0039] Another feature of the device once having entered the scored
state (S3) is the implementation of a refractory period to prevent
multiple scoring of a common hypopnea event. Thus, at 346 the RMS
ventilation is tested to see if it exceeds about a 75% threshold.
The test is comparable to the comparison at 340. If at 346 it does
not exceed the threshold, the device remains in the scored state
(S3). If at 346 it does exceed the threshold, another timing period
or a refractory timing period may be triggered or started at 348
and the device enters a super-75 state (S4). For example, a count
down timer (designated "Super-75 Timer") may be set to a maximum
period of about ten to twenty seconds, but preferably 15 seconds.
Other values for this time setting may be pre-determined depending
on the desired length of the refractory time to ensure that the
scored hypopnea condition has ceased.
[0040] From the super-75 state (S4), the RMS ventilation is checked
at 350 for confirmation that it remains above the threshold of
about 75% like the comparison at 346. If it does, then at 352 the
Super-75 Timer is decremented so it continues to run or count down.
If at 354, the Super-75 Timer has expired or passed the desired
time period, then the device returns to the start state (S0). If
not, the device remains in the super-75 state (S4).
[0041] In sum, the detector determines whether the short-term
ventilation measure falls below a 50% threshold and then stays
there for about 4 seconds. The detector allows excursions above the
50% threshold but not a 75% threshold while the 4 second period is
being accumulated. However, if the 75% threshold is exceeded before
the accumulation period is over then the detector will reset to
start without a hypopnea indication. Once the accumulation is
complete, a hypopnoea is indicated. The detector then requires the
short-term threshold measure to exceed a 75% threshold for a
refractory period such as 15 contiguous seconds before the detector
becomes non-refractory. As implemented, the detector will not score
short hypopnoeas and will tend to allow messy periods of depressed
flow to be scored as one hypopnoea rather than two or more.
[0042] In some embodiments, entering the stored state (S3) or
otherwise indicating or scoring a hypopnea may be further
conditioned on a detection of flow limitation, an obstructive apnea
and/or central apnea, which may be detected by a common processor
as the hypopnea detection processor or a different processor in
electronic communication with the hypopnea detection processor. For
example, the device may be configured to also detect an obstructive
apnea, partial obstruction and/or central apnea by any of the
methods described in U.S. Pat. Nos. 6,138,675 and 6,029,665, the
entire disclosures of which are incorporated herein by cross
reference, which a different processor or detector. Similarly, the
device may be configured to detect a measure of flow limitation,
such as a fuzzy flow limitation measure as disclosed in
PCT/AU008/000647, filed on May 9, 2008, (published as International
Patent Application Publication No. (WO/2008/138040) and U.S.
Provisional Patent Application No. 60/965,172 filed on Aug. 17,
2007, the disclosures of which are hereby incorporated herein by
reference. In such embodiments, the determination of the reduction
in ventilation (e.g., a classification associated with the sub-50
state) in conjunction with a detection of any one or more of a
central apnea, patency of the airway, an absence of partial
obstruction, an obstructive apnea or a low or insufficient measure
of flow limitation, may be taken as a contra-indication of hypopnea
condition. In such a case, the decrease in ventilation may be
considered a result of apnea. For example, if a measure of partial
obstruction or flow limitation indicates that there is
insignificant or no obstruction during the sub-50 timing period,
then rather than scoring a hypopnea, the detector may return to the
start state (S0) or a further wait state (not shown) that provides
a similar refractory timing period to wait for the ventilation
measure to return above a threshold such as the 75% threshold
discussed at 346. Similarly, by way of further example, if a
measure of central apnea or airway patency indicates that there is
a central apnea during the sub-50 timing period, then rather than
scoring a hypopnea, the detector may return to the start state (S0)
or the further wait state that provides a similar refractory timing
period to wait for the ventilation measure to return above a
threshold such as the 75% threshold discussed at 346. As a still
further example, if a measure of obstructive apnea indicates that
there is an obstructive apnea during the sub-50 timing period, then
rather than scoring a hypopnea, the detector may return to the
start state (S0) or the further wait state that provides a similar
refractory timing period to wait for the ventilation measure to
return above a threshold such as the 75% threshold discussed at
346.
[0043] An embodiment of the above detector based on the state
diagram of FIG. 3 was tested on a library of data representing
recorded patient respiratory flow signals. The flow data was
pre-correlated with oxygen desaturation data. The hypopnea detector
analyzed the flow data and hypopnea events were recorded. The
hypopnea events detected were then correlated with the desaturation
event data. A graph of the correlation is illustrated at FIG. 4.
The graph shows that the hypopnea detection methodology correlates
well with desaturation events (ODI) of at least a 4%
desaturation.
[0044] In a further example of the scoring methodology illustrated
in FIG. 3, the states of the state machine may be implemented to
avoid scoring the hypopnea when apnea events (e.g., central apnea
or obstructive apnea) are detected. For example, when the detector
enters the scored state (S3), an hypopnea is merely "pre-logged"
(such as by setting a "pre-logged" variable to true) so that it is
not scored immediately. This may be considered the detection of a
potential hypopnea by the detector. At this time, an apnea detector
(such as an obstructive apnea and/or central apnea detector) may be
polled (e.g., continuously during the state) to determine if the
apnea detector has detected an apnea. If, in response to the
polling, the detection of apnea has been confirmed, then the value
of the "pre-logged" variable may be changed (e.g., set to false)
and the state of the hypopnea detector is advanced to the super-75
state (S4) with the setting of the Super75 Timer at 348. In this
way, the scoring of the hypopnea may be bypassed. Once the detector
advances to the super-75 state (S4) then a potential hypopnea event
will be logged or scored as an hypopnea event based on the
pre-logged variable (e.g., if "pre-logged" variable is true, the
event is logged as an hypopnea; but if the "pre-logged" variable is
false, the event will not be logged or scored as a hypopnea.)
[0045] In this embodiment, the state machine of the detector
advances out of the scored state (S3) by entering the super75 state
(S4). Therefore, if at any time between entering the scored state
and entering the super75 state (S4) an apnea is confirmed, then no
hypopnea will be logged. Further, if at any time an apnea is
confirmed before an hypopnea is scored, then the hypopnea detector
is put into the refractory state and no score is possible until the
refractory period is over. Thus, this embodiment can help to
prevent false positive hypopnea scoring when a potential hypopnea
event is an apnea event. While this embodiment implements a
coordinated apnea and hypopnea detection by separate detectors
(e.g., separate devices or separate software and/or hardware
modules of a common apparatus) that communicate through polling as
described above, in some embodiments, the states of the state
machine above may be modified with additional thresholds intended
for detecting apnea by known methods. In such a case, the output of
a unified state machine of a common software and/or hardware module
could be to detect either a hypopnea condition or an apnea
condition depending on the results of the assessments of the
various thresholds or conditions of the state machine.
[0046] (2) Additional Detection Features
[0047] In some embodiments, a scoring of a hypopnea may also
include a determination of a measure of the severity of the scored
hypopnea. An example of such a methodology is illustrated in FIG.
5. In the example, short-term and long-term measures of ventilation
may be determined from a respiratory flow signal respectively at
540 and 542. For example, the measures may be an RMS ventilation or
variance calculation as discussed in the prior embodiment
determined over short and long time windows (e.g., about 12 and 60
seconds respectively). By way of further example, the ventilation
measures may each be a low pass filtered average ventilation (e.g.,
half of the absolute value of data samples from a flow signal using
short and long time constants). In still further embodiments, a
long-term average tidal volume over multiple breaths and a recent
tidal volume of one or an average of several breaths may be
utilized as ventilation measures. At 544 a threshold as a function
of the long-term measure is determined. For example, the threshold
may be a portion or proportion of the measure (e.g., 50%, 75%,
etc.). The threshold may be empirically determined based on
hypopnea conditions in patients. Then at 546, the detection device
detects a hypopnea or the severity of a hypopnea with the threshold
and the short-term measure by, for example, measuring an area
bounded by first and second crossings of the short-term measure of
ventilation and the threshold.
[0048] An example of the technology may be considered in
conjunction with the illustrated graph of FIG. 6. The graph plots a
long-term ventilation measure 650 and a short-term ventilation
measure 652, which may be determined from a measured respiratory
flow signal. The graph also illustrates a threshold 650P determined
as a function of the long-term ventilation measure. The extent of
the bounded area A, which may provide a measure of severity of a
hypopnea incident, may be determined by the detection device with
the data from these measures. For example, this bounded area A may
be determined by the following example formula:
A=.intg..sub.a.sup.bf(x)-g(x)dx
Where:
[0049] f(x) is a proportion of a long-term measure of
ventilation;
[0050] G(x) is the short-term measure of ventilation;
[0051] a and b are first and second crossings of f(x) and g(x), and
may delimit a period of time at least ten seconds in length.
[0052] In an example embodiment, the integration of the ventilation
measures may be implemented by sampling of these signals at a
common time and by consecutively adding sample differences of the
threshold and the short-term measure (i.e., f(x)-g(x), where x is a
sample time) from time (a) to time (b). As shown in FIG. 6, the
adding operation may be initiated (at "Trigger a") by comparing the
threshold and the short-term measure to determine that the
short-term measure is less than the threshold (e.g., G(x)<=F(x)
at x=a). The adding operation may then stop (at "Trigger b") by
again comparing the threshold and short-term ventilation (e.g.,
G(x)>=F(x) at x=b) to determine that the short-term measure has
exceeded the threshold. The resulting sum may be taken as the
severity measure. In some embodiments, if the time period over
which samples were taken (e.g., a sample count) does not exceed a
chosen time period indicative of hypopnea, such as about 10
seconds, the measure of severity may be disregarded (e.g., if
(b-a)<10 seconds).
[0053] These area determination methods of FIG. 5 may optionally be
implemented along with the scoring methodologies of FIGS. 2 and 3
to provide a severity measure for each scored event and/or to
provide a joint hypoponea score based on both methodologies. For
example, a hypopnea may be counted by a detector if either method
or, alternatively, both methods detect the occurrence of a
hypopnea. The severity measure may then be provided for the counted
hypopnea. However, the area methods may also be implemented
independent of the former methods as independent detectors.
[0054] Thus, the area measurement may be utilized to not only score
a hypopnea but to provide a measure of its severity as well. For
example, the severity measure may be compared to a threshold
indicative of hypopnea. For example, a predetermined threshold may
be empirically determined to be indicative of desaturation, such as
about a 4% desaturation event. Thus, by comparing the severity
measure to such a threshold, a hypopnea event may be scored.
Optionally, its severity may be further analyzed or quantified by,
for example, determining a value that it exceeds the threshold or
as a ratio with the threshold. Still further, the value of the area
itself may serve as the measure of severity.
[0055] In some embodiments, the length of the hypopnea, such as its
time or duration, may also serve as a measure of severity. As with
the area measure, it may be compared to one or more thresholds to
assess the hypopnea event. In some embodiments, the area measure,
the length or duration and the count, may be each analyzed to score
a hypopnea and/or define its severity. For example, a hypopnea
event scored by any of the described embodiments may be further
characterized by its length and area to indicate severity.
[0056] In still further embodiments of the hypopnea detection
technology, hypopnea events may be characterized or classified by
type, such as by determining that an hypopnea event is an
obstructive hypopnea or determining that the hypopnea event is a
central hypopnea. In this way, the detector may distinguish between
different types of hypopneas. For example, the common occurrence of
(1) an hypopnea event detected by any of the methodologies herein,
such as in the absence of a confirmation of a detected apnea, and
(2) the detection of any one or more of (a) a measure of flow
limitation (e.g., by analysis of a flow limitation index), (b)
detecting a breath or breathing cycle during the hypopnea (e.g.,
confirming patient triggering of the transition from an expiration
state to inspiration state based on triggering threshold) and/or
(c) a measure of partial obstruction, may be collectively taken as
a detection of an obstructive hypopnea for scoring rather than a
central hypopnea. Similarly, the common occurrence of (1) a
hypopnea event detected by any of the methodologies herein, such as
in the absence of a confirmation of a detected apnea, and (2) the
detection of any one or more of (a) a patency condition of the
airway, (b) a failure to detect a breath or breathing cycle (e.g.,
an absence of patient triggering of the transition from an
expiration state to inspiration state after a period of time based
on triggering threshold) and/or (c) an absence of flow limitation
or partial obstruction, may be collectively taken as a detection of
an central hypopnea for scoring rather than an obstructive
hypopnea. Thus, while a number of scored hypopnea events may be
presented as a total of both obstructive hypopneas and central
hypopneas, some embodiments of the present technology may also be
implemented to score or report a break down of the number of
obstructive hypopneas separately from the number of central
hypopneas determined by the detector.
[0057] By way of further example, in one such embodiment of the
detector, obstructive hypopnea events may be scored while hypopnea
events that are attributable to central events are not scored. In
the example, hypopnea events detected by any of the methods
described herein that also coincide with a flow limitation index
satisfying a desired threshold may be scored as a hypopnea or as an
obstructive hypopnea. However, in the event that a detected
hypopnea event coincides with the absence of a detection of a
breath or breathing cycle, no hypopnea may be scored. In such a
case the failure to detect a breath or breathing cycle (e.g., an
absence of patient triggering of the transition from an expiration
state to inspiration state after a period of time based on
triggering threshold) may be considered an indicator of a central
event (e.g., central apnea).
[0058] Example Architecture
[0059] An example system architecture of a controller is
illustrated in the block diagram of FIG. 7. In the illustration,
the hypopnea detection device 701 or general purpose computer may
include one or more processors 708. The device may also include a
display interface 710 to output hypopnea detection reports (e.g.,
hypopnea counts and/or severity measures), results or graphs (e.g.,
area curves as illustrated in FIG. 6) as described herein such as
on a monitor or LCD panel. A user control/input interface 712, for
example, for a keyboard, touch panel, control buttons, mouse etc.
may also be provided to activate the methodologies described
herein. The device may also include a sensor or data interface 714,
such as a bus, for receiving/transmitting data such as programming
instructions, oximetery data, flow data, hypopnea detection data
etc. The device may also typically include a memory/data storage
components containing control instructions of the aforementioned
methodologies (e.g., FIGS. 2-6). These may include processor
control instructions for flow or oximetery signal processing (e.g.,
pre-processing methods, filters) at 722 as discussed in more detail
herein. They may also include processor control instructions for
ventilation measure determination (e.g., variance, RMS calculations
etc.) at 724. They may also include processor control instructions
for Hypopnea detection or severity measurement (e.g., threshold
determination, comparison, area measuring, triggering, timing
methods, scoring etc.) at 726. Finally, they may also include
stored data 728 for these methodologies such as detected hypopnea
events and/or hypopnea severity measures, threshold proportions,
timing thresholds, reports and graphs, etc.)
[0060] In some embodiments, the processor control instructions and
data for controlling the above described methodologies may be
contained in a computer readable recording medium as software for
use by a general purpose computer so that the general purpose
computer may serve as a specific purpose computer according to any
of the methodologies discussed herein upon loading the software
into the general purpose computer.
[0061] In the foregoing description and in the accompanying
drawings, specific terminology, equations and drawing symbols are
set forth to provide a thorough understanding of the present
technology. In some instances, the terminology and symbols may
imply specific details that are not required to practice the
technology. For example, although the terms "first" and "second"
have been used herein, unless otherwise specified, the language is
not intended to provide any specified order but merely to assist in
explaining distinct elements of the technology. Furthermore,
although process steps in the detection methodologies have been
illustrated in the figures in an order, such an ordering is not
required. Those skilled in the art will recognize that such
ordering may be modified and/or aspects thereof may be conducted in
parallel.
[0062] Moreover, although the technology herein has been described
with reference to particular embodiments, it is to be understood
that these embodiments are merely illustrative of the principles
and applications of the technology. It is therefore to be
understood that numerous modifications may be made to the
illustrative embodiments and that other arrangements may be devised
without departing from the spirit and scope of the technology. For
example, while the above scoring and severity measuring
methodologies may be performed without measured blood oxygen data,
in some embodiments, a detector may further include access to
desaturation data from an oximetry sensor to classify hypopneas
with actual SpO.sub.2 data and ventilation or airflow data, such as
by a method of the AASM guidelines. In such an embodiment, the
detector may implement hypopnea detection with the SpO.sub.2 data
and without as described in prior embodiments (e.g., FIGS. 2, 3 and
5). Thus, the device may score a hypopnea by detection with either
methodology or alternatively, with a detection by both
methodologies. Such an embodiment may also be utilized to compare
results from both methodologies to evaluate either methodology or
to provide a treatment of the detected hypopneas if detected by
either or both methodologies.
[0063] Additional example embodiments of the herein disclosed
technology may also be understood upon consideration of the
following descriptive paragraphs. To this end, the technology may
also involve:
[0064] A method for controlling a processor to detect a hypopnea
from a measured flow of breathable gas, the method of the processor
comprising: determining a first measure from a short-term variance
of data based on a measured flow of breathable gas; determining a
second measure from a long-term variance of data based on a
measured flow of breathable gas; comparing the first measure with
first and second proportions of the second measure; and indicating
a detection of the hypopnea based on the comparing if the first
measure falls below the first proportion and does not subsequently
exceed a range of the first and second proportions during a first
time period.
[0065] The method of any of the proceeding paragraphs wherein the
first proportion is less than the second proportion and further
comprising indicating a detection of a hypopnea if the first
measure does not exceed the first proportion during the first time
period.
[0066] The method of any of the proceeding paragraphs wherein the
first proportion is less than the second proportion and further
comprising indicating a detection of a hypopnea if the first
measure exceeds the first proportion but does not exceed the second
proportion during the first time period.
[0067] The method of any of the proceeding paragraphs further
comprising detecting a measure of flow limitation from a measured
flow of breathable gas and wherein the indicating the detection of
the hypopnea is further based on the measure of flow limitation
being indicative of obstruction.
[0068] The method of any of the proceeding paragraphs wherein the
comparing of the first measure and the first proportion represents
a determination of whether an RMS value calculated from
approximately ten to fifteen seconds of respiratory flow data falls
below a threshold of approximately fifty percent of an RMS value
calculated from approximately fifty to seventy seconds of
respiratory flow data and wherein the first period of time is
approximately three to eight seconds.
[0069] The method of any of the proceeding paragraphs wherein the
comparing of the second measure and the second proportion
represents a determination of whether an RMS value calculated from
approximately ten to fifteen seconds of respiratory flow data is
below a threshold of approximately seventy five percent of an RMS
value calculated from approximately fifty to seventy seconds of
respiratory flow data.
[0070] The method of any of the proceeding paragraphs wherein the
comparing of the first measure and the first proportion represents
a determination of whether an RMS value calculated from
approximately ten to fifteen seconds of respiratory flow data falls
below a threshold of approximately fifty percent of an RMS value
calculated from approximately fifty to seventy seconds of
respiratory flow data and wherein the first period of time is
approximately three to eight seconds.
[0071] The method of any of the proceeding paragraphs further
comprising impeding a further detection of a hypopnea until the
first measure exceeds the second proportion during a second period
of time.
[0072] The method of any of the proceeding paragraphs wherein the
impeding of the further detection comprises comparing of the first
measure and the second proportion, wherein this comparing
represents a determination of whether an RMS value calculated from
approximately ten to fifteen seconds of respiratory flow data
exceeds a threshold of approximately seventy five percent of an RMS
value calculated from approximately fifty to seventy seconds of
respiratory flow data and wherein the second period of time is
approximately ten to twenty seconds.
[0073] The method of any of the proceeding paragraphs further
comprising measuring a flow of breathable gas with a flow
sensor.
[0074] A hypopnea detection apparatus comprising: a controller
having at least one processor to access data representing a
measured flow of breathable gas, the controller being further
configured to: determine a first measure from a short-term variance
of the data; determine a second measure from a long-term variance
of the data; compare the first measure with first and second
proportions of the second measure; and indicate a detection of the
hypopnea based on the comparing if the first measure falls below
the first proportion and does not subsequently exceed a range of
the first and second proportions during a first time period.
[0075] The apparatus of any of the proceeding paragraphs wherein
the first proportion is less than the second proportion and wherein
the controller is further configured to indicate a detection of a
hypopnea if the first measure does not exceed the first proportion
during the first time period.
[0076] The apparatus of any of the proceeding paragraphs wherein
the first proportion is less than the second proportion and wherein
the controller is further configured to indicate a detection of a
hypopnea if the first measure exceeds the first proportion but does
not exceed the second proportion during the first time period.
[0077] The apparatus of any of the proceeding paragraphs wherein
the controller is further configured to detect a measure of flow
limitation from the data and wherein the indicating the detection
of the hypopnea is further based on the measure of flow limitation
being indicative of obstruction.
[0078] The apparatus of any of the proceeding paragraphs wherein
the comparing of the first measure and the first proportion
represents a determination of whether an RMS value calculated from
approximately ten to fifteen seconds of respiratory flow data falls
below a threshold of approximately fifty percent of an RMS value
calculated from approximately fifty to seventy seconds of
respiratory flow data and wherein the first period of time is
approximately three to eight seconds.
[0079] The apparatus of any of the proceeding paragraphs wherein
the comparing of the second measure and the second proportion
represents a determination of whether an RMS value calculated from
approximately ten to fifteen seconds of respiratory flow data is
below a threshold of approximately seventy five percent of an RMS
value calculated from approximately fifty to seventy seconds of
respiratory flow data.
[0080] The apparatus of any of the proceeding paragraphs wherein
the comparing of the first measure and the first proportion
represents a determination of whether an RMS value calculated from
approximately ten to fifteen seconds of respiratory flow data falls
below a threshold of approximately fifty percent of an RMS value
calculated from approximately fifty to seventy seconds of
respiratory flow data and wherein the first period of time is
approximately three to eight seconds.
[0081] The apparatus of any of the proceeding paragraphs wherein
the controller is further configured to impede a further detection
of a hypopnea until the first measure exceeds the second proportion
during a second period of time.
[0082] The apparatus of any of the proceeding paragraphs wherein
the impeding of the further detection comprises comparing of the
first measure and the second proportion, wherein this comparing
represents a determination of whether an RMS value calculated from
approximately ten to fifteen seconds of respiratory flow data
exceeds a threshold of approximately seventy five percent of an RMS
value calculated from approximately fifty to seventy seconds of
respiratory flow data and wherein the second period of time is
approximately ten to twenty seconds.
[0083] The apparatus of any of the proceeding paragraphs further
comprising a flow sensor and wherein the controller is further
configured to determine the measured flow of breathable gas with
the flow sensor.
[0084] The apparatus of any of the proceeding paragraphs further
comprising: a flow generator configured to produce a breathable gas
for a patient at a pressure above atmospheric pressure; wherein the
controller is further configured to control the flow generator to
produce the breathable gas according to a pressure therapy regime
based on the detected hypopnea.
[0085] A method for controlling a processor to detect a hypopnea
from a measured flow of breathable gas, the method of the processor
comprising: determining a long-term measure of ventilation;
determining a short-term measure of ventilation; determining a
threshold as a proportion of the long-term measure of ventilation;
measuring an area bounded by first and second crossings of the
short-term measure of ventilation and the threshold; and detecting
the hypopnea with the measured area.
[0086] The method of any of the preceding paragraphs wherein the
measuring comprises integrating a difference between the threshold
and the short-term measure of ventilation during a time period from
when the short-term measure falls below the threshold to when the
short-term measure exceeds the threshold.
[0087] The method of any of the preceding paragraphs wherein the
measuring comprises adding a plurality of sample differences during
a time period from when the short-term measure falls below the
threshold to when the short-term measure exceeds the threshold,
wherein each sample difference is a difference between a sample of
the threshold and a sample of the short-term measure of
ventilation.
[0088] The method of any of the preceding paragraphs further
comprising impeding a further detection of a hypopnea during a
refractory period initiated at the second crossing.
[0089] The method of any of the preceding paragraphs further
comprising triggering the measuring of the area upon detecting the
first crossing by comparing the short-term measure of ventilation
and the threshold for inequality.
[0090] The method of any of the preceding paragraphs wherein the
detecting of the hypopnea is contingent upon a time from the first
crossing to the second crossing exceeding about ten seconds.
[0091] The method of any of the preceding paragraphs wherein the
short-term measure of ventilation comprises an output of low pass
filtering half of an absolute value of a measure of flow of
breathable gas with a first time constant.
[0092] The method of any of the preceding paragraphs wherein the
long-term measure of ventilation comprises an output of low pass
filtering half of an absolute value of a measure of flow of
breathable gas with a second time constant, the second time
constant being larger than the first time constant.
[0093] The method of any of the preceding paragraphs wherein the
proportion comprises approximately seventy percent.
[0094] The method of any of the preceding paragraphs further
comprising indicating a severity of the hypopnea with the measure
of area.
[0095] The method of any of the preceding paragraphs wherein the
detecting comprises comparing the measured area with a threshold
chosen to be approximately indicative of a desaturation of blood
oxygen of at least four percent.
[0096] The method of any of the preceding paragraphs further
comprising measuring a flow of breathable gas with a flow
sensor.
[0097] The method of any of the preceding paragraphs further
comprising detecting a measure of flow limitation from the measured
flow signal and wherein the detection of the hypopnea is further
based on the measure of flow limitation being indicative of
obstruction.
[0098] An apparatus to detect a hypopnea from a measured flow of
breathable gas, the apparatus comprising: a controller having at
least one processor to access data representing a measured flow of
breathable gas, the controller being further configured to:
determine a long-term measure of ventilation from the measured
flow; determine a short-term measure of ventilation from the
measured flow; determine a threshold as a proportion of the
long-term measure of ventilation; measure an area bounded by first
and second crossings of the short-term measure of ventilation and
the threshold; and detect the hypopnea with the measured area.
[0099] The apparatus of any of the preceding paragraphs wherein the
controller is configured to measure the area by integrating a
difference between the threshold and the short-term measure of
ventilation during a time period from when the short-term measure
falls below the threshold to when the short-term measure exceeds
the threshold.
[0100] The apparatus of any of the preceding paragraphs wherein the
controller is configured to measure the area by adding a plurality
of sample differences during a time period from when the short-term
measure falls below the threshold to when the short-term measure
exceeds the threshold, wherein each sample difference is a
difference between a sample of the threshold and a sample of the
short-term measure of ventilation.
[0101] The apparatus of any of the preceding paragraphs wherein the
controller is further configured to impede a further detection of a
hypopnea during a refractory period initiated by detection of the
second crossing.
[0102] The apparatus of any of the preceding paragraphs wherein the
controller is further configured to trigger the measuring of the
area upon detecting the first crossing by comparing the short-term
measure of ventilation and the threshold for inequality.
[0103] The apparatus of any of the preceding paragraphs wherein the
detection of the hypopnea is contingent upon a time from the first
crossing to the second crossing exceeding about ten seconds.
[0104] The apparatus of any of the preceding paragraphs wherein the
short-term measure of ventilation comprises an output of low pass
filtering half of an absolute value of a measure of flow of
breathable gas with a first time constant.
[0105] The apparatus of any of the preceding paragraphs wherein the
long-term measure of ventilation comprises an output of low pass
filtering half of an absolute value of a measure of flow of
breathable gas with a second time constant, the second time
constant being larger than the first time constant.
[0106] The apparatus of any of the preceding paragraphs wherein the
proportion comprises approximately seventy percent.
[0107] The apparatus of any of the preceding paragraphs wherein the
controller is further configured to indicate a severity of the
hypopnea with the measure of area.
[0108] The apparatus of any of the preceding paragraphs wherein the
detecting comprises comparing the measured area with a threshold
chosen to be approximately indicative of a desaturation of blood
oxygen of at least four percent.
[0109] The apparatus of any of the preceding paragraphs wherein the
controller is further configured to detect a measure of flow
limitation from the data and wherein the detection of the hypopnea
is further based on the measure of flow limitation being indicative
of obstruction.
[0110] The apparatus of any of the preceding paragraphs further
comprising a flow sensor and wherein the controller is further
configured to determine the measured flow of breathable gas with
the flow sensor.
[0111] The apparatus of any of the preceding paragraphs further
comprising: a flow generator configured to produce a breathable gas
for a patient at a pressure above atmospheric pressure; wherein the
controller is further configured to control the flow generator to
produce the breathable gas according to a pressure therapy regime
based on the detected hypopnea.
[0112] A method for controlling a processor to detect a hypopnea
from a measured flow of breathable gas, the method of the processor
comprising: determining a long-term measure of ventilation;
determining a short-term measure of ventilation; determining a
threshold as a proportion of the long-term measure of ventilation;
calculating an extent of a hypopnea as a function of the short-term
measure of ventilation and the threshold; and indicating a severity
of the hypopnea with the measured extent.
[0113] The method of any of the preceding paragraphs wherein the
indicating comprises outputting a value of the measured extent.
[0114] The method of any of the preceding paragraphs wherein the
calculated extent is a calculated area bounded by first and second
crossings of the short-term measure of ventilation and the
threshold.
[0115] The method of any of the preceding paragraphs further
comprising comparing the calculated area with a threshold chosen to
be approximately indicative of a desaturation of blood oxygen of at
least four percent.
[0116] The method of any of the preceding paragraphs further
comprising measuring a flow of breathable gas with a flow
sensor.
[0117] The method of any of the preceding paragraphs further
comprising detecting a measure of flow limitation from the measure
flow and wherein the indicating the detection of the hypopnea is
further based on the measure of flow limitation being indicative of
obstruction.
[0118] An apparatus to detect a hypopnea from a measured flow of
breathable gas, the apparatus comprising: a controller having at
least one processor to access data representing a measured flow of
breathable gas, the controller being further configured to:
determine a long-term measure of ventilation from the data;
determine a short-term measure of ventilation from the data;
determine a threshold as a proportion of the long-term measure of
ventilation; calculate an extent of a hypopnea as a function of the
short-term measure of ventilation and the threshold; and indicate a
severity of the hypopnea with the calculated extent.
[0119] The apparatus of any of the preceding paragraphs wherein the
controller is configured to indicate the severity by outputting a
value of the calculated extent to an output device.
[0120] The apparatus of any of the preceding paragraphs wherein the
controller calculates the extent by calculating an area bounded by
first and second crossings of the short-term measure of ventilation
and the threshold.
[0121] The apparatus of any of the preceding paragraphs wherein the
controller is further configured to compare the calculated area
with a threshold chosen to be approximately indicative of a
desaturation of blood oxygen of at least four percent.
[0122] The apparatus of any of the preceding paragraphs further
comprising a flow sensor and wherein the controller is further
configured to determine the measured flow of breathable gas with
the flow sensor.
[0123] The apparatus of any of the preceding paragraphs further
comprising: a flow generator configured to produce a breathable gas
for a patient at a pressure above atmospheric pressure; wherein the
controller is further configured to control the flow generator to
produce the breathable gas according to a pressure therapy regime
based on the detected hypopnea.
[0124] The apparatus of any of the preceding paragraphs wherein the
controller is further configured to detect a measure of flow
limitation from the data and wherein the indicating the detection
of the hypopnea is further based on the measure of flow limitation
being indicative of obstruction.
[0125] A method for controlling a processor to classify a hypopnea
from a measured flow of breathable gas, the method of the processor
comprising: detecting an hypopnea event from a measured flow of
breathable gas; determining a measure indicative of obstruction in
the measured flow coincident with the hypopnea event; and
classifying the detected hypopnea event as obstructive or central
based on the determining of the measure indicative of
obstruction.
[0126] The method of any of the preceding paragraphs wherein the
determining comprises detecting partial obstruction and the
classifying comprises scoring an obstructive hypopnea event.
[0127] The method of any of the preceding paragraphs further
comprising detecting an absence of a breath and the classifying
comprises scoring a central hypopnea event.
[0128] The method of any of the preceding paragraphs further
comprising detecting an absence of a breath coincident with a
further detected hypopnea event and refraining from scoring the
further detected hypopnea event based on the detected absence of a
breath.
[0129] A hypopnea detection apparatus comprising: a controller
having at least one processor to access data representing a
measured flow of breathable gas, the controller being further
configured to control: a detection of an hypopnea event from the
data representing the measured flow of breathable gas; a
determination of a measure indicative of obstruction coincident
with the hypopnea event in the data representing the measured flow;
and a classification the detected hypopnea event as obstructive or
central based on the determining of the measure indicative of
obstruction.
[0130] The apparatus of any of the preceding paragraphs wherein the
determination detects partial obstruction and the classification
comprises scoring an obstructive hypopnea event.
[0131] The apparatus of any of the preceding paragraphs wherein the
controller is further configured to control a detection of an
absence of a breath and the classification comprises scoring a
central hypopnea event.
[0132] The apparatus of any of the preceding paragraphs wherein the
controller is further configured to detect an absence of a breath
coincident with a further detected hypopnea event and to refrain
from scoring the further detected hypopnea event based on the
detected absence of a breath.
[0133] The apparatus of any of the preceding paragraphs further
comprising: a flow generator configured to produce a breathable gas
for a patient at a pressure above atmospheric pressure; and a flow
sensor, wherein the controller is further configured to measure the
flow of breathable gas with the flow sensor and to control the flow
generator to produce the breathable gas according to a pressure
therapy regime based on the detected hypopnea.
* * * * *