U.S. patent application number 12/715848 was filed with the patent office on 2010-10-21 for human receptor proteins; related reagents and methods. This patent application is currently assigned to SCHERING CORPORATION. Invention is credited to J. FERNANDO BAZAN, GERARD T. HARDIMAN, STEPHEN W.K. HO, ROBERT A. KASTELEIN, YONG-JUN LIU, FERNANDO L. ROCK.
Application Number | 20100266599 12/715848 |
Document ID | / |
Family ID | 27534860 |
Filed Date | 2010-10-21 |
United States Patent Application | 20100266599 |
Kind Code | A1 |
HARDIMAN; GERARD T. ; et al. | October 21, 2010 |
Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
Inventors: | HARDIMAN; GERARD T.; (SAN DIEGO, CA) ; ROCK; FERNANDO L.; (LA HONDA, CA) ; BAZAN; J. FERNANDO; (MENLO PARK, CA) ; KASTELEIN; ROBERT A.; (PORTOLA VALLEY, CA) ; HO; STEPHEN W.K.; (PALO ALTO, CA) ; LIU; YONG-JUN; (PEARLAND, TX) |
Correspondence Address: |
MERCK;PATENT DEPARTMENT (K-6-1, 1990) 2000 GALLOPING HILL ROAD KENILWORTH NJ 07033-0530 US |
Assignee: | SCHERING CORPORATION |
Family ID: | 27534860 |
Appl. No.: | 12/715848 |
Filed: | March 2, 2010 |
Application Number | Filing Date | Patent Number | ||
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12100008 | Apr 9, 2008 | |||
12715848 | ||||
11844179 | Aug 23, 2007 | |||
12100008 | ||||
10975909 | Oct 28, 2004 | 7271248 | ||
11844179 | ||||
09950041 | Sep 10, 2001 | |||
10975909 | ||||
09728540 | Nov 28, 2000 | |||
09950041 | ||||
09073363 | May 6, 1998 | |||
09728540 | ||||
60207558 | May 25, 2000 | |||
60044293 | May 7, 1997 | |||
60072212 | Jan 22, 1998 | |||
60076947 | Mar 5, 1998 | |||
Current U.S. Class: | 424/139.1 ; 435/320.1; 530/350; 530/387.9; 530/391.1; 530/391.3; 536/23.1 |
Current CPC Class: | A61P 35/02 20180101; A61P 35/00 20180101; C07K 2319/00 20130101; A61P 31/00 20180101; A61P 31/12 20180101; A61P 37/00 20180101; A61K 38/00 20130101; C07K 14/705 20130101 |
Class at Publication: | 424/139.1 ; 530/350; 536/23.1; 435/320.1; 530/387.9; 530/391.3; 530/391.1 |
International Class: | A61K 39/395 20060101 A61K039/395; C07K 14/00 20060101 C07K014/00; C07H 21/00 20060101 C07H021/00; C12N 15/63 20060101 C12N015/63; C07K 16/00 20060101 C07K016/00; A61P 31/00 20060101 A61P031/00; A61P 31/12 20060101 A61P031/12; A61P 35/02 20060101 A61P035/02; A61P 35/00 20060101 A61P035/00; A61P 37/00 20060101 A61P037/00 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 94 <210> SEQ ID NO 1 <211> LENGTH: 2367
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(2358) <220> FEATURE: <221> NAME/KEY:
mat_peptide <222> LOCATION: (67)..(2358) <400>
SEQUENCE: 1 atg act agc atc ttc cat ttt gcc att atc ttc atg tta ata
ctt cag 48 Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile
Leu Gln -20 -15 -10 atc aga ata caa tta tct gaa gaa agt gaa ttt tta
gtt gat agg tca 96 Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu
Val Asp Arg Ser -5 -1 1 5 10 aaa aac ggt ctc atc cac gtt cct aaa
gac cta tcc cag aaa aca aca 144 Lys Asn Gly Leu Ile His Val Pro Lys
Asp Leu Ser Gln Lys Thr Thr 15 20 25 atc tta aat ata tcg caa aat
tat ata tct gag ctt tgg act tct gac 192 Ile Leu Asn Ile Ser Gln Asn
Tyr Ile Ser Glu Leu Trp Thr Ser Asp 30 35 40 atc tta tca ctg tca
aaa ctg agg att ttg ata att tct cat aat aga 240 Ile Leu Ser Leu Ser
Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 45 50 55 atc cag tat
ctt gat atc agt gtt ttc aaa ttc aac cag gaa ttg gaa 288 Ile Gln Tyr
Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 60 65 70 tac
ttg gat ttg tcc cac aac aag ttg gtg aag att tct tgc cac cct 336 Tyr
Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 75 80
85 90 act gtg aac ctc aag cac ttg gac ctg tca ttt aat gca ttt gat
gcc 384 Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp
Ala 95 100 105 ctg cct ata tgc aaa gag ttt ggc aat atg tct caa cta
aaa ttt ctg 432 Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu
Lys Phe Leu 110 115 120 ggg ttg agc acc aca cac tta gaa aaa tct agt
gtg ctg cca att gct 480 Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser
Val Leu Pro Ile Ala 125 130 135 cat ttg aat atc agc aag gtc ttg ctg
gtc tta gga gag act tat ggg 528 His Leu Asn Ile Ser Lys Val Leu Leu
Val Leu Gly Glu Thr Tyr Gly 140 145 150 gaa aaa gaa gac cct gag ggc
ctt caa gac ttt aac act gag agt ctg 576 Glu Lys Glu Asp Pro Glu Gly
Leu Gln Asp Phe Asn Thr Glu Ser Leu 155 160 165 170 cac att gtg ttc
ccc aca aac aaa gaa ttc cat ttt att ttg gat gtg 624 His Ile Val Phe
Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 175 180 185 tca gtc
aag act gta gca aat ctg gaa cta tct aat atc aaa tgt gtg 672 Ser Val
Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 190 195 200
cta gaa gat aac aaa tgt tct tac ttc cta agt att ctg gcg aaa ctt 720
Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 205
210 215 caa aca aat cca aag tta tca agt ctt acc tta aac aac att gaa
aca 768 Gln Thr Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu
Thr 220 225 230 act tgg aat tct ttc att agg atc ctc caa cta gtt tgg
cat aca act 816 Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp
His Thr Thr 235 240 245 250 gta tgg tat ttc tca att tca aac gtg aag
cta cag ggt cag ctg gac 864 Val Trp Tyr Phe Ser Ile Ser Asn Val Lys
Leu Gln Gly Gln Leu Asp 255 260 265 ttc aga gat ttt gat tat tct ggc
act tcc ttg aag gcc ttg tct ata 912 Phe Arg Asp Phe Asp Tyr Ser Gly
Thr Ser Leu Lys Ala Leu Ser Ile 270 275 280 cac caa gtt gtc agc gat
gtg ttc ggt ttt ccg caa agt tat atc tat 960 His Gln Val Val Ser Asp
Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 285 290 295 gaa atc ttt tcg
aat atg aac atc aaa aat ttc aca gtg tct ggt aca 1008 Glu Ile Phe
Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 300 305 310 cgc
atg gtc cac atg ctt tgc cca tcc aaa att agc ccg ttc ctg cat 1056
Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 315
320 325 330 ttg gat ttt tcc aat aat ctc tta aca gac acg gtt ttt gaa
aat tgt 1104 Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe
Glu Asn Cys 335 340 345 ggg cac ctt act gag ttg gag aca ctt att tta
caa atg aat caa tta 1152 Gly His Leu Thr Glu Leu Glu Thr Leu Ile
Leu Gln Met Asn Gln Leu 350 355 360 aaa gaa ctt tca aaa ata gct gaa
atg act aca cag atg aag tct ctg 1200 Lys Glu Leu Ser Lys Ile Ala
Glu Met Thr Thr Gln Met Lys Ser Leu 365 370 375 caa caa ttg gat att
agc cag aat tct gta agc tat gat gaa aag aaa 1248 Gln Gln Leu Asp
Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 380 385 390 gga gac
tgt tct tgg act aaa agt tta tta agt tta aat atg tct tca 1296 Gly
Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 395 400
405 410 aat ata ctt act gac act att ttc aga tgt tta cct ccc agg atc
aag 1344 Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg
Ile Lys 415 420 425 gta ctt gat ctt cac agc aat aaa ata aag agc att
cct aaa caa gtc 1392 Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser
Ile Pro Lys Gln Val 430 435 440 gta aaa ctg gaa gct ttg caa gaa ctc
aat gtt gct ttc aat tct tta 1440 Val Lys Leu Glu Ala Leu Gln Glu
Leu Asn Val Ala Phe Asn Ser Leu 445 450 455 act gac ctt cct gga tgt
ggc agc ttt agc agc ctt tct gta ttg atc 1488 Thr Asp Leu Pro Gly
Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 460 465 470 att gat cac
aat tca gtt tcc cac cca tca gct gat ttc ttc cag agc 1536 Ile Asp
His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 475 480 485
490 tgc cag aag atg agg tca ata aaa gca ggg gac aat cca ttc caa tgt
1584 Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln
Cys 495 500 505 acc tgt gag ctc gga gaa ttt gtc aaa aat ata gac caa
gta tca agt 1632 Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp
Gln Val Ser Ser 510 515 520 gaa gtg tta gag ggc tgg cct gat tct tat
aag tgt gac tac ccg gaa 1680 Glu Val Leu Glu Gly Trp Pro Asp Ser
Tyr Lys Cys Asp Tyr Pro Glu 525 530 535 agt tat aga gga acc cta cta
aag gac ttt cac atg tct gaa tta tcc 1728 Ser Tyr Arg Gly Thr Leu
Leu Lys Asp Phe His Met Ser Glu Leu Ser 540 545 550 tgc aac ata act
ctg ctg atc gtc acc atc gtt gcc acc atg ctg gtg 1776 Cys Asn Ile
Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 555 560 565 570
ttg gct gtg act gtg acc tcc ctc tgc atc tac ttg gat ctg ccc tgg
1824 Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro
Trp 575 580 585 tat ctc agg atg gtg tgc cag tgg acc cag acc cgg cgc
agg gcc agg 1872 Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg
Arg Arg Ala Arg 590 595 600 aac ata ccc tta gaa gaa ctc caa aga aat
ctc cag ttt cat gca ttt 1920 Asn Ile Pro Leu Glu Glu Leu Gln Arg
Asn Leu Gln Phe His Ala Phe 605 610 615 att tca tat agt ggg cac gat
tct ttc tgg gtg aag aat gaa tta ttg 1968 Ile Ser Tyr Ser Gly His
Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 620 625 630 cca aac cta gag
aaa gaa ggt atg cag att tgc ctt cat gag aga aac 2016 Pro Asn Leu
Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 635 640 645 650
ttt gtt cct ggc aag agc att gtg gaa aat atc atc acc tgc att gag
2064 Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile
Glu 655 660 665 aag agt tac aag tcc atc ttt gtt ttg tct ccc aac ttt
gtc cag agt 2112 Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn
Phe Val Gln Ser 670 675 680 gaa tgg tgc cat tat gaa ctc tac ttt gcc
cat cac aat ctc ttt cat 2160 Glu Trp Cys His Tyr Glu Leu Tyr Phe
Ala His His Asn Leu Phe His 685 690 695 gaa gga tct aat agc tta atc
ctg atc ttg ctg gaa ccc att ccg cag 2208 Glu Gly Ser Asn Ser Leu
Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 700 705 710 tac tcc att cct
agc agt tat cac aag ctc aaa agt ctc atg gcc agg 2256 Tyr Ser Ile
Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 715 720 725 730
agg act tat ttg gaa tgg ccc aag gaa aag agc aaa cgt ggc ctt ttt
2304 Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu
Phe 735 740 745 tgg gct aac tta agg gca gcc att aat att aag ctg aca
gag caa gca 2352 Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu
Thr Glu Gln Ala 750 755 760 aag aaa tagtctaga 2367 Lys Lys
<210> SEQ ID NO 2 <211> LENGTH: 786 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 2 Met
Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln -20 -15
-10 Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser
-5 -1 1 5 10 Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln
Lys Thr Thr 15 20 25 Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu
Leu Trp Thr Ser Asp 30 35 40 Ile Leu Ser Leu Ser Lys Leu Arg Ile
Leu Ile Ile Ser His Asn Arg 45 50 55 Ile Gln Tyr Leu Asp Ile Ser
Val Phe Lys Phe Asn Gln Glu Leu Glu 60 65 70 Tyr Leu Asp Leu Ser
His Asn Lys Leu Val Lys Ile Ser Cys His Pro 75 80 85 90 Thr Val Asn
Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 95 100 105 Leu
Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 110 115
120 Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala
125 130 135 His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr
Tyr Gly 140 145 150 Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn
Thr Glu Ser Leu 155 160 165 170 His Ile Val Phe Pro Thr Asn Lys Glu
Phe His Phe Ile Leu Asp Val 175 180 185 Ser Val Lys Thr Val Ala Asn
Leu Glu Leu Ser Asn Ile Lys Cys Val 190 195 200 Leu Glu Asp Asn Lys
Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 205 210 215 Gln Thr Asn
Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 220 225 230 Thr
Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 235 240
245 250 Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu
Asp 255 260 265 Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala
Leu Ser Ile 270 275 280 His Gln Val Val Ser Asp Val Phe Gly Phe Pro
Gln Ser Tyr Ile Tyr 285 290 295 Glu Ile Phe Ser Asn Met Asn Ile Lys
Asn Phe Thr Val Ser Gly Thr 300 305 310 Arg Met Val His Met Leu Cys
Pro Ser Lys Ile Ser Pro Phe Leu His 315 320 325 330 Leu Asp Phe Ser
Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 335 340 345 Gly His
Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 350 355 360
Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 365
370 375 Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys
Lys 380 385 390 Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn
Met Ser Ser 395 400 405 410 Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys
Leu Pro Pro Arg Ile Lys 415 420 425 Val Leu Asp Leu His Ser Asn Lys
Ile Lys Ser Ile Pro Lys Gln Val 430 435 440 Val Lys Leu Glu Ala Leu
Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 445 450 455 Thr Asp Leu Pro
Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 460 465 470 Ile Asp
His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 475 480 485
490 Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys
495 500 505 Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val
Ser Ser 510 515 520 Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys
Asp Tyr Pro Glu 525 530 535 Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe
His Met Ser Glu Leu Ser 540 545 550 Cys Asn Ile Thr Leu Leu Ile Val
Thr Ile Val Ala Thr Met Leu Val 555 560 565 570 Leu Ala Val Thr Val
Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 575 580 585 Tyr Leu Arg
Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 590 595 600 Asn
Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 605 610
615 Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu
620 625 630 Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu
Arg Asn 635 640 645 650 Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile
Ile Thr Cys Ile Glu 655 660 665 Lys Ser Tyr Lys Ser Ile Phe Val Leu
Ser Pro Asn Phe Val Gln Ser 670 675 680 Glu Trp Cys His Tyr Glu Leu
Tyr Phe Ala His His Asn Leu Phe His 685 690 695 Glu Gly Ser Asn Ser
Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 700 705 710 Tyr Ser Ile
Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 715 720 725 730
Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 735
740 745 Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln
Ala 750 755 760 Lys Lys <210> SEQ ID NO 3 <211> LENGTH:
2355 <212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(2352) <220> FEATURE: <221> NAME/KEY:
mat_peptide <222> LOCATION: (67)..(2352) <400>
SEQUENCE: 3 atg cca cat act ttg tgg atg gtg tgg gtc ttg ggg gtc atc
atc agc 48 Met Pro His Thr Leu Trp Met Val Trp Val Leu Gly Val Ile
Ile Ser -20 -15 -10 ctc tcc aag gaa gaa tcc tcc aat cag gct tct ctg
tct tgt gac cgc 96 Leu Ser Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu
Ser Cys Asp Arg -5 -1 1 5 10 aat ggt atc tgc aag ggc agc tca gga
tct tta aac tcc att ccc tca 144 Asn Gly Ile Cys Lys Gly Ser Ser Gly
Ser Leu Asn Ser Ile Pro Ser 15 20 25 ggg ctc aca gaa gct gta aaa
agc ctt gac ctg tcc aac aac agg atc 192 Gly Leu Thr Glu Ala Val Lys
Ser Leu Asp Leu Ser Asn Asn Arg Ile 30 35 40 acc tac att agc aac
agt gac cta cag agg tgt gtg aac ctc cag gct 240 Thr Tyr Ile Ser Asn
Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala 45 50 55 ctg gtg ctg
aca tcc aat gga att aac aca ata gag gaa gat tct ttt 288 Leu Val Leu
Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe 60 65 70 tct
tcc ctg ggc agt ctt gaa cat tta gac tta tcc tat aat tac tta 336 Ser
Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr Leu 75 80
85 90 tct aat tta tcg tct tcc tgg ttc aag ccc ctt tct tct tta aca
ttc 384 Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser Leu Thr
Phe 95 100 105 tta aac tta ctg gga aat cct tac aaa acc cta ggg gaa
aca tct ctt 432 Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu Gly Glu
Thr Ser Leu 110 115 120 ttt tct cat ctc aca aaa ttg caa atc ctg aga
gtg gga aat atg gac 480 Phe Ser His Leu Thr Lys Leu Gln Ile Leu Arg
Val Gly Asn Met Asp 125 130 135 acc ttc act aag att caa aga aaa gat
ttt gct gga ctt acc ttc ctt 528 Thr Phe Thr Lys Ile Gln Arg Lys Asp
Phe Ala Gly Leu Thr Phe Leu 140 145 150 gag gaa ctt gag att gat gct
tca gat cta cag agc tat gag cca aaa 576 Glu Glu Leu Glu Ile Asp Ala
Ser Asp Leu Gln Ser Tyr Glu Pro Lys 155 160 165 170 agt ttg aag tca
att cag aac gta agt cat ctg atc ctt cat atg aag 624 Ser Leu Lys Ser
Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys 175 180 185 cag cat
att tta ctg ctg gag att ttt gta gat gtt aca agt tcc gtg 672 Gln His
Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val 190 195 200
gaa tgt ttg gaa ctg cga gat act gat ttg gac act ttc cat ttt tca 720
Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe Ser 205
210 215 gaa cta tcc act ggt gaa aca aat tca ttg att aaa aag ttt aca
ttt 768 Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys Phe Thr
Phe 220 225 230 aga aat gtg aaa atc acc gat gaa agt ttg ttt cag gtt
atg aaa ctt 816 Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe Gln Val
Met Lys Leu 235 240 245 250 ttg aat cag att tct gga ttg tta gaa tta
gag ttt gat gac tgt acc 864 Leu Asn Gln Ile Ser Gly Leu Leu Glu Leu
Glu Phe Asp Asp Cys Thr 255 260 265 ctt aat gga gtt ggt aat ttt aga
gca tct gat aat gac aga gtt ata 912 Leu Asn Gly Val Gly Asn Phe Arg
Ala Ser Asp Asn Asp Arg Val Ile 270 275 280 gat cca ggt aaa gtg gaa
acg tta aca atc cgg agg ctg cat att cca 960 Asp Pro Gly Lys Val Glu
Thr Leu Thr Ile Arg Arg Leu His Ile Pro 285 290 295 agg ttt tac tta
ttt tat gat ctg agc act tta tat tca ctt aca gaa 1008 Arg Phe Tyr
Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu 300 305 310 aga
gtt aaa aga atc aca gta gaa aac agt aaa gtt ttt ctg gtt cct 1056
Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 315
320 325 330 tgt tta ctt tca caa cat tta aaa tca tta gaa tac ttg gat
ctc agt 1104 Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu
Asp Leu Ser 335 340 345 gaa aat ttg atg gtt gaa gaa tac ttg aaa aat
tca gcc tgt gag gat 1152 Glu Asn Leu Met Val Glu Glu Tyr Leu Lys
Asn Ser Ala Cys Glu Asp 350 355 360 gcc tgg ccc tct cta caa act tta
att tta agg caa aat cat ttg gca 1200 Ala Trp Pro Ser Leu Gln Thr
Leu Ile Leu Arg Gln Asn His Leu Ala 365 370 375 tca ttg gaa aaa acc
gga gag act ttg ctc act ctg aaa aac ttg act 1248 Ser Leu Glu Lys
Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr 380 385 390 aac att
gat atc agt aag aat agt ttt cat tct atg cct gaa act tgt 1296 Asn
Ile Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys 395 400
405 410 cag tgg cca gaa aag atg aaa tat ttg aac tta tcc agc aca cga
ata 1344 Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr
Arg Ile 415 420 425 cac agt gta aca ggc tgc att ccc aag aca ctg gaa
att tta gat gtt 1392 His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu
Glu Ile Leu Asp Val 430 435 440 agc aac aac aat ctc aat tta ttt tct
ttg aat ttg ccg caa ctc aaa 1440 Ser Asn Asn Asn Leu Asn Leu Phe
Ser Leu Asn Leu Pro Gln Leu Lys 445 450 455 gaa ctt tat att tcc aga
aat aag ttg atg act cta cca gat gcc tcc 1488 Glu Leu Tyr Ile Ser
Arg Asn Lys Leu Met Thr Leu Pro Asp Ala Ser 460 465 470 ctc tta ccc
atg tta cta gta ttg aaa atc agt agg aat gca ata act 1536 Leu Leu
Pro Met Leu Leu Val Leu Lys Ile Ser Arg Asn Ala Ile Thr 475 480 485
490 acg ttt tct aag gag caa ctt gac tca ttt cac aca ctg aag act ttg
1584 Thr Phe Ser Lys Glu Gln Leu Asp Ser Phe His Thr Leu Lys Thr
Leu 495 500 505 gaa gct ggt ggc aat aac ttc att tgc tcc tgt gaa ttc
ctc tcc ttc 1632 Glu Ala Gly Gly Asn Asn Phe Ile Cys Ser Cys Glu
Phe Leu Ser Phe 510 515 520 act cag gag cag caa gca ctg gcc aaa gtc
ttg att gat tgg cca gca 1680 Thr Gln Glu Gln Gln Ala Leu Ala Lys
Val Leu Ile Asp Trp Pro Ala 525 530 535 aat tac ctg tgt gac tct cca
tcc cat gtg cgt ggc cag cag gtt cag 1728 Asn Tyr Leu Cys Asp Ser
Pro Ser His Val Arg Gly Gln Gln Val Gln 540 545 550 gat gtc cgc ctc
tcg gtg tcg gaa tgt cac agg aca gca ctg gtg tct 1776 Asp Val Arg
Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu Val Ser 555 560 565 570
ggc atg tgc tgt gct ctg ttc ctg ctg atc ctg ctc acg ggg gtc ctg
1824 Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu Thr Gly Val
Leu 575 580 585 tgc cac cgt ttc cat ggc ctg tgg tat atg aaa atg atg
tgg gcc tgg 1872 Cys His Arg Phe His Gly Leu Trp Tyr Met Lys Met
Met Trp Ala Trp 590 595 600 ctc cag gcc aaa agg aag ccc agg aaa gct
ccc agc agg aac atc tgc 1920 Leu Gln Ala Lys Arg Lys Pro Arg Lys
Ala Pro Ser Arg Asn Ile Cys 605 610 615 tat gat gca ttt gtt tct tac
agt gag cgg gat gcc tac tgg gtg gag 1968 Tyr Asp Ala Phe Val Ser
Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu 620 625 630 aac ctt atg gtc
cag gag ctg gag aac ttc aat ccc ccc ttc aag ttg 2016 Asn Leu Met
Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu 635 640 645 650
tgt ctt cat aag cgg gac ttc att cct ggc aag tgg atc att gac aat
2064 Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp
Asn 655 660 665 atc att gac tcc att gaa aag agc cac aaa act gtc ttt
gtg ctt tct 2112 Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val
Phe Val Leu Ser 670 675 680 gaa aac ttt gtg aag agt gag tgg tgc aag
tat gaa ctg gac ttc tcc 2160 Glu Asn Phe Val Lys Ser Glu Trp Cys
Lys Tyr Glu Leu Asp Phe Ser 685 690 695 cat ttc cgt ctt ttt gaa gag
aac aat gat gct gcc att ctc att ctt 2208 His Phe Arg Leu Phe Glu
Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu 700 705 710 ctg gag ccc att
gag aaa aaa gcc att ccc cag cgc ttc tgc aag ctg 2256 Leu Glu Pro
Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu 715 720 725 730
cgg aag ata atg aac acc aag acc tac ctg gag tgg ccc atg gac gag
2304 Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp
Glu 735 740 745 gct cag cgg gaa gga ttt tgg gta aat ctg aga gct gcg
ata aag tcc 2352 Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala
Ala Ile Lys Ser 750 755 760 tag 2355 <210> SEQ ID NO 4
<211> LENGTH: 784 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 4 Met Pro His Thr Leu Trp Met
Val Trp Val Leu Gly Val Ile Ile Ser -20 -15 -10 Leu Ser Lys Glu Glu
Ser Ser Asn Gln Ala Ser Leu Ser Cys Asp Arg -5 -1 1 5 10 Asn Gly
Ile Cys Lys Gly Ser Ser Gly Ser Leu Asn Ser Ile Pro Ser 15 20 25
Gly Leu Thr Glu Ala Val Lys Ser Leu Asp Leu Ser Asn Asn Arg Ile 30
35 40 Thr Tyr Ile Ser Asn Ser Asp Leu Gln Arg Cys Val Asn Leu Gln
Ala 45 50 55 Leu Val Leu Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu
Asp Ser Phe 60 65 70 Ser Ser Leu Gly Ser Leu Glu His Leu Asp Leu
Ser Tyr Asn Tyr Leu 75 80 85 90 Ser Asn Leu Ser Ser Ser Trp Phe Lys
Pro Leu Ser Ser Leu Thr Phe 95 100 105 Leu Asn Leu Leu Gly Asn Pro
Tyr Lys Thr Leu Gly Glu Thr Ser Leu 110 115 120 Phe Ser His Leu Thr
Lys Leu Gln Ile Leu Arg Val Gly Asn Met Asp 125 130 135 Thr Phe Thr
Lys Ile Gln Arg Lys Asp Phe Ala Gly Leu Thr Phe Leu 140 145 150 Glu
Glu Leu Glu Ile Asp Ala Ser Asp Leu Gln Ser Tyr Glu Pro Lys 155 160
165 170 Ser Leu Lys Ser Ile Gln Asn Val Ser His Leu Ile Leu His Met
Lys 175 180 185 Gln His Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr
Ser Ser Val 190 195 200 Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp
Thr Phe His Phe Ser 205 210 215 Glu Leu Ser Thr Gly Glu Thr Asn Ser
Leu Ile Lys Lys Phe Thr Phe 220 225 230 Arg Asn Val Lys Ile Thr Asp
Glu Ser Leu Phe Gln Val Met Lys Leu 235 240 245 250 Leu Asn Gln Ile
Ser Gly Leu Leu Glu Leu Glu Phe Asp Asp Cys Thr 255 260 265 Leu Asn
Gly Val Gly Asn Phe Arg Ala Ser Asp Asn Asp Arg Val Ile 270 275 280
Asp Pro Gly Lys Val Glu Thr Leu Thr Ile Arg Arg Leu His Ile Pro 285
290 295 Arg Phe Tyr Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr
Glu 300 305 310 Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe
Leu Val Pro 315 320 325 330 Cys Leu Leu Ser Gln His Leu Lys Ser Leu
Glu Tyr Leu Asp Leu Ser 335 340 345 Glu Asn Leu Met Val Glu Glu Tyr
Leu Lys Asn Ser Ala Cys Glu Asp 350 355 360 Ala Trp Pro Ser Leu Gln
Thr Leu Ile Leu Arg Gln Asn His Leu Ala 365 370 375 Ser Leu Glu Lys
Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr 380 385 390 Asn Ile
Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys 395 400 405
410 Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile
415 420 425 His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu
Asp Val 430 435 440 Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu
Pro Gln Leu Lys 445 450 455 Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met
Thr Leu Pro Asp Ala Ser 460 465 470 Leu Leu Pro Met Leu Leu Val Leu
Lys Ile Ser Arg Asn Ala Ile Thr 475 480 485 490 Thr Phe Ser Lys Glu
Gln Leu Asp Ser Phe His Thr Leu Lys Thr Leu 495 500 505 Glu Ala Gly
Gly Asn Asn Phe Ile Cys Ser Cys Glu Phe Leu Ser Phe 510 515 520 Thr
Gln Glu Gln Gln Ala Leu Ala Lys Val Leu Ile Asp Trp Pro Ala 525 530
535 Asn Tyr Leu Cys Asp Ser Pro Ser His Val Arg Gly Gln Gln Val Gln
540 545 550 Asp Val Arg Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu
Val Ser 555 560 565 570 Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu
Leu Thr Gly Val Leu 575 580 585 Cys His Arg Phe His Gly Leu Trp Tyr
Met Lys Met Met Trp Ala Trp 590 595 600 Leu Gln Ala Lys Arg Lys Pro
Arg Lys Ala Pro Ser Arg Asn Ile Cys 605 610 615 Tyr Asp Ala Phe Val
Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu 620 625 630 Asn Leu Met
Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu 635 640 645 650
Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn 655
660 665 Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu
Ser 670 675 680 Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu
Asp Phe Ser 685 690 695 His Phe Arg Leu Phe Glu Glu Asn Asn Asp Ala
Ala Ile Leu Ile Leu 700 705 710 Leu Glu Pro Ile Glu Lys Lys Ala Ile
Pro Gln Arg Phe Cys Lys Leu 715 720 725 730 Arg Lys Ile Met Asn Thr
Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu 735 740 745 Ala Gln Arg Glu
Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 750 755 760
<210> SEQ ID NO 5 <211> LENGTH: 2715 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(2712)
<220> FEATURE: <221> NAME/KEY: mat_peptide <222>
LOCATION: (64)..(2712) <400> SEQUENCE: 5 atg aga cag act ttg
cct tgt atc tac ttt tgg ggg ggc ctt ttg ccc 48 Met Arg Gln Thr Leu
Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro -20 -15 -10 ttt ggg atg
ctg tgt gca tcc tcc acc acc aag tgc act gtt agc cat 96 Phe Gly Met
Leu Cys Ala Ser Ser Thr Thr Lys Cys Thr Val Ser His -5 -1 1 5 10
gaa gtt gct gac tgc agc cac ctg aag ttg act cag gta ccc gat gat 144
Glu Val Ala Asp Cys Ser His Leu Lys Leu Thr Gln Val Pro Asp Asp 15
20 25 cta ccc aca aac ata aca gtg ttg aac ctt acc cat aat caa ctc
aga 192 Leu Pro Thr Asn Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu
Arg 30 35 40 aga tta cca gcc gcc aac ttc aca agg tat agc cag cta
act agc ttg 240 Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu
Thr Ser Leu 45 50 55 gat gta gga ttt aac acc atc tca aaa ctg gag
cca gaa ttg tgc cag 288 Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu
Pro Glu Leu Cys Gln 60 65 70 75 aaa ctt ccc atg tta aaa gtt ttg aac
ctc cag cac aat gag cta tct 336 Lys Leu Pro Met Leu Lys Val Leu Asn
Leu Gln His Asn Glu Leu Ser 80 85 90 caa ctt tct gat aaa acc ttt
gcc ttc tgc acg aat ttg act gaa ctc 384 Gln Leu Ser Asp Lys Thr Phe
Ala Phe Cys Thr Asn Leu Thr Glu Leu 95 100 105 cat ctc atg tcc aac
tca atc cag aaa att aaa aat aat ccc ttt gtc 432 His Leu Met Ser Asn
Ser Ile Gln Lys Ile Lys Asn Asn Pro Phe Val 110 115 120 aag cag aag
aat tta atc aca tta gat ctg tct cat aat ggc ttg tca 480 Lys Gln Lys
Asn Leu Ile Thr Leu Asp Leu Ser His Asn Gly Leu Ser 125 130 135 tct
aca aaa tta gga act cag gtt cag ctg gaa aat ctc caa gag ctt 528 Ser
Thr Lys Leu Gly Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 140 145
150 155 cta tta tca aac aat aaa att caa gcg cta aaa agt gaa gaa ctg
gat 576 Leu Leu Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu
Asp 160 165 170 atc ttt gcc aat tca tct tta aaa aaa tta gag ttg tca
tcg aat caa 624 Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser
Ser Asn Gln 175 180 185 att aaa gag ttt tct cca ggg tgt ttt cac gca
att gga aga tta ttt 672 Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala
Ile Gly Arg Leu Phe 190 195 200 ggc ctc ttt ctg aac aat gtc cag ctg
ggt ccc agc ctt aca gag aag 720 Gly Leu Phe Leu Asn Asn Val Gln Leu
Gly Pro Ser Leu Thr Glu Lys 205 210 215 cta tgt ttg gaa tta gca aac
aca agc att cgg aat ctg tct ctg agt 768 Leu Cys Leu Glu Leu Ala Asn
Thr Ser Ile Arg Asn Leu Ser Leu Ser 220 225 230 235 aac agc cag ctg
tcc acc acc agc aat aca act ttc ttg gga cta aag 816 Asn Ser Gln Leu
Ser Thr Thr Ser Asn Thr Thr Phe Leu Gly Leu Lys 240 245 250 tgg aca
aat ctc act atg ctc gat ctt tcc tac aac aac tta aat gtg 864 Trp Thr
Asn Leu Thr Met Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val 255 260 265
gtt ggt aac gat tcc ttt gct tgg ctt cca caa cta gaa tat ttc ttc 912
Val Gly Asn Asp Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 270
275 280 cta gag tat aat aat ata cag cat ttg ttt tct cac tct ttg cac
ggg 960 Leu Glu Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His
Gly 285 290 295 ctt ttc aat gtg agg tac ctg aat ttg aaa cgg tct ttt
act aaa caa 1008 Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser
Phe Thr Lys Gln 300 305 310 315 agt att tcc ctt gcc tca ctc ccc aag
att gat gat ttt tct ttt cag 1056 Ser Ile Ser Leu Ala Ser Leu Pro
Lys Ile Asp Asp Phe Ser Phe Gln 320 325 330 tgg cta aaa tgt ttg gag
cac ctt aac atg gaa gat aat gat att cca 1104 Trp Leu Lys Cys Leu
Glu His Leu Asn Met Glu Asp Asn Asp Ile Pro 335 340 345 ggc ata aaa
agc aat atg ttc aca gga ttg ata aac ctg aaa tac tta 1152 Gly Ile
Lys Ser Asn Met Phe Thr Gly Leu Ile Asn Leu Lys Tyr Leu 350 355 360
agt cta tcc aac tcc ttt aca agt ttg cga act ttg aca aat gaa aca
1200 Ser Leu Ser Asn Ser Phe Thr Ser Leu Arg Thr Leu Thr Asn Glu
Thr 365 370 375 ttt gta tca ctt gct cat tct ccc tta cac ata ctc aac
cta acc aag 1248 Phe Val Ser Leu Ala His Ser Pro Leu His Ile Leu
Asn Leu Thr Lys 380 385 390 395 aat aaa atc tca aaa ata gag agt gat
gct ttc tct tgg ttg ggc cac 1296 Asn Lys Ile Ser Lys Ile Glu Ser
Asp Ala Phe Ser Trp Leu Gly His 400 405 410 cta gaa gta ctt gac ctg
ggc ctt aat gaa att ggg caa gaa ctc aca 1344 Leu Glu Val Leu Asp
Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr 415 420 425 ggc cag gaa
tgg aga ggt cta gaa aat att ttc gaa atc tat ctt tcc 1392 Gly Gln
Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr Leu Ser 430 435 440
tac aac aag tac ctg cag ctg act agg aac tcc ttt gcc ttg gtc cca
1440 Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe Ala Leu Val
Pro 445 450 455 agc ctt caa cga ctg atg ctc cga agg gtg gcc ctt aaa
aat gtg gat 1488 Ser Leu Gln Arg Leu Met Leu Arg Arg Val Ala Leu
Lys Asn Val Asp 460 465 470 475 agc tct cct tca cca ttc cag cct ctt
cgt aac ttg acc att ctg gat 1536 Ser Ser Pro Ser Pro Phe Gln Pro
Leu Arg Asn Leu Thr Ile Leu Asp 480 485 490 cta agc aac aac aac ata
gcc aac ata aat gat gac atg ttg gag ggt 1584 Leu Ser Asn Asn Asn
Ile Ala Asn Ile Asn Asp Asp Met Leu Glu Gly 495 500 505 ctt gag aaa
cta gaa att ctc gat ttg cag cat aac aac tta gca cgg 1632 Leu Glu
Lys Leu Glu Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg 510 515 520
ctc tgg aaa cac gca aac cct ggt ggt ccc att tat ttc cta aag ggt
1680 Leu Trp Lys His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys
Gly 525 530 535 ctg tct cac ctc cac atc ctt aac ttg gag tcc aac ggc
ttt gac gag 1728 Leu Ser His Leu His Ile Leu Asn Leu Glu Ser Asn
Gly Phe Asp Glu 540 545 550 555 atc cca gtt gag gtc ttc aag gat tta
ttt gaa cta aag atc atc gat 1776 Ile Pro Val Glu Val Phe Lys Asp
Leu Phe Glu Leu Lys Ile Ile Asp 560 565 570 tta gga ttg aat aat tta
aac aca ctt cca gca tct gtc ttt aat aat 1824 Leu Gly Leu Asn Asn
Leu Asn Thr Leu Pro Ala Ser Val Phe Asn Asn 575 580 585 cag gtg tct
cta aag tca ttg aac ctt cag aag aat ctc ata aca tcc 1872 Gln Val
Ser Leu Lys Ser Leu Asn Leu Gln Lys Asn Leu Ile Thr Ser 590 595 600
gtt gag aag aag gtt ttc ggg cca gct ttc agg aac ctg act gag tta
1920 Val Glu Lys Lys Val Phe Gly Pro Ala Phe Arg Asn Leu Thr Glu
Leu 605 610 615 gat atg cgc ttt aat ccc ttt gat tgc acg tgt gaa agt
att gcc tgg 1968 Asp Met Arg Phe Asn Pro Phe Asp Cys Thr Cys Glu
Ser Ile Ala Trp 620 625 630 635 ttt gtt aat tgg att aac gag acc cat
acc aac atc cct gag ctg tca 2016 Phe Val Asn Trp Ile Asn Glu Thr
His Thr Asn Ile Pro Glu Leu Ser 640 645 650 agc cac tac ctt tgc aac
act cca cct cac tat cat ggg ttc cca gtg 2064 Ser His Tyr Leu Cys
Asn Thr Pro Pro His Tyr His Gly Phe Pro Val 655 660 665 aga ctt ttt
gat aca tca tct tgc aaa gac agt gcc ccc ttt gaa ctc 2112 Arg Leu
Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu Leu 670 675 680
ttt ttc atg atc aat acc agt atc ctg ttg att ttt atc ttt att gta
2160 Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile
Val 685 690 695 ctt ctc atc cac ttt gag ggc tgg agg ata tct ttt tat
tgg aat gtt 2208 Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser Phe
Tyr Trp Asn Val 700 705 710 715 tca gta cat cga gtt ctt ggt ttc aaa
gaa ata gac aga cag aca gaa 2256 Ser Val His Arg Val Leu Gly Phe
Lys Glu Ile Asp Arg Gln Thr Glu 720 725 730 cag ttt gaa tat gca gca
tat ata att cat gcc tat aaa gat aag gat 2304 Gln Phe Glu Tyr Ala
Ala Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp 735 740 745 tgg gtc tgg
gaa cat ttc tct tca atg gaa aag gaa gac caa tct ctc 2352 Trp Val
Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu 750 755 760
aaa ttt tgt ctg gaa gaa agg gac ttt gag gcg ggt gtt ttt gaa cta
2400 Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu
Leu 765 770 775 gaa gca att gtt aac agc atc aaa aga agc aga aaa att
att ttt gtt 2448 Glu Ala Ile Val Asn Ser Ile Lys Arg Ser Arg Lys
Ile Ile Phe Val 780 785 790 795 ata aca cac cat cta tta aaa gac cca
tta tgc aaa aga ttc aag gta 2496 Ile Thr His His Leu Leu Lys Asp
Pro Leu Cys Lys Arg Phe Lys Val 800 805 810 cat cat gca gtt caa caa
gct att gaa caa aat ctg gat tcc att ata 2544 His His Ala Val Gln
Gln Ala Ile Glu Gln Asn Leu Asp Ser Ile Ile 815 820 825 ttg gtt ttc
ctt gag gag att cca gat tat aaa ctg aac cat gca ctc 2592 Leu Val
Phe Leu Glu Glu Ile Pro Asp Tyr Lys Leu Asn His Ala Leu 830 835 840
tgt ttg cga aga gga atg ttt aaa tct cac tgc atc ttg aac tgg cca
2640 Cys Leu Arg Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp
Pro 845 850 855 gtt cag aaa gaa cgg ata ggt gcc ttt cgt cat aaa ttg
caa gta gca 2688 Val Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys
Leu Gln Val Ala 860 865 870 875 ctt gga tcc aaa aac tct gta cat taa
2715 Leu Gly Ser Lys Asn Ser Val His 880 <210> SEQ ID NO 6
<211> LENGTH: 904 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 6 Met Arg Gln Thr Leu Pro Cys
Ile Tyr Phe Trp Gly Gly Leu Leu Pro -20 -15 -10 Phe Gly Met Leu Cys
Ala Ser Ser Thr Thr Lys Cys Thr Val Ser His -5 -1 1 5 10 Glu Val
Ala Asp Cys Ser His Leu Lys Leu Thr Gln Val Pro Asp Asp 15 20 25
Leu Pro Thr Asn Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg 30
35 40 Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser
Leu 45 50 55 Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu
Leu Cys Gln 60 65 70 75 Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln
His Asn Glu Leu Ser 80 85 90 Gln Leu Ser Asp Lys Thr Phe Ala Phe
Cys Thr Asn Leu Thr Glu Leu 95 100 105 His Leu Met Ser Asn Ser Ile
Gln Lys Ile Lys Asn Asn Pro Phe Val 110 115 120 Lys Gln Lys Asn Leu
Ile Thr Leu Asp Leu Ser His Asn Gly Leu Ser 125 130 135 Ser Thr Lys
Leu Gly Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 140 145 150 155
Leu Leu Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp 160
165 170 Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn
Gln 175 180 185 Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly
Arg Leu Phe 190 195 200 Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro
Ser Leu Thr Glu Lys 205 210 215 Leu Cys Leu Glu Leu Ala Asn Thr Ser
Ile Arg Asn Leu Ser Leu Ser 220 225 230 235 Asn Ser Gln Leu Ser Thr
Thr Ser Asn Thr Thr Phe Leu Gly Leu Lys 240 245 250 Trp Thr Asn Leu
Thr Met Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val 255 260 265 Val Gly
Asn Asp Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 270 275 280
Leu Glu Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly 285
290 295 Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys
Gln 300 305 310 315 Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp
Phe Ser Phe Gln 320 325 330 Trp Leu Lys Cys Leu Glu His Leu Asn Met
Glu Asp Asn Asp Ile Pro 335 340 345 Gly Ile Lys Ser Asn Met Phe Thr
Gly Leu Ile Asn Leu Lys Tyr Leu 350 355 360 Ser Leu Ser Asn Ser Phe
Thr Ser Leu Arg Thr Leu Thr Asn Glu Thr 365 370 375 Phe Val Ser Leu
Ala His Ser Pro Leu His Ile Leu Asn Leu Thr Lys 380 385 390 395 Asn
Lys Ile Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu Gly His 400 405
410 Leu Glu Val Leu Asp Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr
415 420 425 Gly Gln Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr
Leu Ser 430 435 440 Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe
Ala Leu Val Pro 445 450 455 Ser Leu Gln Arg Leu Met Leu Arg Arg Val
Ala Leu Lys Asn Val Asp 460 465 470 475 Ser Ser Pro Ser Pro Phe Gln
Pro Leu Arg Asn Leu Thr Ile Leu Asp 480 485 490 Leu Ser Asn Asn Asn
Ile Ala Asn Ile Asn Asp Asp Met Leu Glu Gly 495 500 505 Leu Glu Lys
Leu Glu Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg 510 515 520 Leu
Trp Lys His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly 525 530
535 Leu Ser His Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu
540 545 550 555 Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys
Ile Ile Asp 560 565 570 Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala
Ser Val Phe Asn Asn 575 580 585 Gln Val Ser Leu Lys Ser Leu Asn Leu
Gln Lys Asn Leu Ile Thr Ser 590 595 600 Val Glu Lys Lys Val Phe Gly
Pro Ala Phe Arg Asn Leu Thr Glu Leu 605 610 615 Asp Met Arg Phe Asn
Pro Phe Asp Cys Thr Cys Glu Ser Ile Ala Trp 620 625 630 635 Phe Val
Asn Trp Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu Ser 640 645 650
Ser His Tyr Leu Cys Asn Thr Pro Pro His Tyr His Gly Phe Pro Val 655
660 665 Arg Leu Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu
Leu 670 675 680 Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile
Phe Ile Val 685 690 695 Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser
Phe Tyr Trp Asn Val 700 705 710 715 Ser Val His Arg Val Leu Gly Phe
Lys Glu Ile Asp Arg Gln Thr Glu 720 725 730 Gln Phe Glu Tyr Ala Ala
Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp 735 740 745 Trp Val Trp Glu
His Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu 750 755 760 Lys Phe
Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu 765 770 775
Glu Ala Ile Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val 780
785 790 795 Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe
Lys Val 800 805 810 His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu
Asp Ser Ile Ile 815 820 825 Leu Val Phe Leu Glu Glu Ile Pro Asp Tyr
Lys Leu Asn His Ala Leu 830 835 840 Cys Leu Arg Arg Gly Met Phe Lys
Ser His Cys Ile Leu Asn Trp Pro 845 850 855 Val Gln Lys Glu Arg Ile
Gly Ala Phe Arg His Lys Leu Gln Val Ala 860 865 870 875 Leu Gly Ser
Lys Asn Ser Val His 880 <210> SEQ ID NO 7 <211> LENGTH:
2400 <212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(2397) <400> SEQUENCE: 7 atg gag ctg aat ttc
tac aaa atc ccc gac aac ctc ccc ttc tca acc 48 Met Glu Leu Asn Phe
Tyr Lys Ile Pro Asp Asn Leu Pro Phe Ser Thr 1 5 10 15 aag aac ctg
gac ctg agc ttt aat ccc ctg agg cat tta ggc agc tat 96 Lys Asn Leu
Asp Leu Ser Phe Asn Pro Leu Arg His Leu Gly Ser Tyr 20 25 30 agc
ttc ttc agt ttc cca gaa ctg cag gtg ctg gat tta tcc agg tgt 144 Ser
Phe Phe Ser Phe Pro Glu Leu Gln Val Leu Asp Leu Ser Arg Cys 35 40
45 gaa atc cag aca att gaa gat ggg gca tat cag agc cta agc cac ctc
192 Glu Ile Gln Thr Ile Glu Asp Gly Ala Tyr Gln Ser Leu Ser His Leu
50 55 60 tct acc tta ata ttg aca gga aac ccc atc cag agt tta gcc
ctg gga 240 Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile Gln Ser Leu Ala
Leu Gly 65 70 75 80 gcc ttt tct gga cta tca agt tta cag aag ctg gtg
gct gtg gag aca 288 Ala Phe Ser Gly Leu Ser Ser Leu Gln Lys Leu Val
Ala Val Glu Thr 85 90 95 aat cta gca tct cta gag aac ttc ccc att
gga cat ctc aaa act ttg 336 Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile
Gly His Leu Lys Thr Leu 100 105 110 aaa gaa ctt aat gtg gct cac aat
ctt atc caa tct ttc aaa tta cct 384 Lys Glu Leu Asn Val Ala His Asn
Leu Ile Gln Ser Phe Lys Leu Pro 115 120 125 gag tat ttt tct aat ctg
acc aat cta gag cac ttg gac ctt tcc agc 432 Glu Tyr Phe Ser Asn Leu
Thr Asn Leu Glu His Leu Asp Leu Ser Ser 130 135 140 aac aag att caa
agt att tat tgc aca gac ttg cgg gtt cta cat caa 480 Asn Lys Ile Gln
Ser Ile Tyr Cys Thr Asp Leu Arg Val Leu His Gln 145 150 155 160 atg
ccc cta ctc aat ctc tct tta gac ctg tcc ctg aac cct atg aac 528 Met
Pro Leu Leu Asn Leu Ser Leu Asp Leu Ser Leu Asn Pro Met Asn 165 170
175 ttt atc caa cca ggt gca ttt aaa gaa att agg ctt cat aag ctg act
576 Phe Ile Gln Pro Gly Ala Phe Lys Glu Ile Arg Leu His Lys Leu Thr
180 185 190 tta aga aat aat ttt gat agt tta aat gta atg aaa act tgt
att caa 624 Leu Arg Asn Asn Phe Asp Ser Leu Asn Val Met Lys Thr Cys
Ile Gln 195 200 205 ggt ctg gct ggt tta gaa gtc cat cgt ttg gtt ctg
gga gaa ttt aga 672 Gly Leu Ala Gly Leu Glu Val His Arg Leu Val Leu
Gly Glu Phe Arg 210 215 220 aat gaa gga aac ttg gaa aag ttt gac aaa
tct gct cta gag ggc ctg 720 Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys
Ser Ala Leu Glu Gly Leu 225 230 235 240 tgc aat ttg acc att gaa gaa
ttc cga tta gca tac tta gac tac tac 768 Cys Asn Leu Thr Ile Glu Glu
Phe Arg Leu Ala Tyr Leu Asp Tyr Tyr 245 250 255 ctc gat gat att att
gac tta ttt aat tgt ttg aca aat gtt tct tca 816 Leu Asp Asp Ile Ile
Asp Leu Phe Asn Cys Leu Thr Asn Val Ser Ser 260 265 270 ttt tcc ctg
gtg agt gtg act att gaa agg gta aaa gac ttt tct tat 864 Phe Ser Leu
Val Ser Val Thr Ile Glu Arg Val Lys Asp Phe Ser Tyr 275 280 285 aat
ttc gga tgg caa cat tta gaa tta gtt aac tgt aaa ttt gga cag 912 Asn
Phe Gly Trp Gln His Leu Glu Leu Val Asn Cys Lys Phe Gly Gln 290 295
300 ttt ccc aca ttg aaa ctc aaa tct ctc aaa agg ctt act ttc act tcc
960 Phe Pro Thr Leu Lys Leu Lys Ser Leu Lys Arg Leu Thr Phe Thr Ser
305 310 315 320 aac aaa ggt ggg aat gct ttt tca gaa gtt gat cta cca
agc ctt gag 1008 Asn Lys Gly Gly Asn Ala Phe Ser Glu Val Asp Leu
Pro Ser Leu Glu 325 330 335 ttt cta gat ctc agt aga aat ggc ttg agt
ttc aaa ggt tgc tgt tct 1056 Phe Leu Asp Leu Ser Arg Asn Gly Leu
Ser Phe Lys Gly Cys Cys Ser 340 345 350 caa agt gat ttt ggg aca acc
agc cta aag tat tta gat ctg agc ttc 1104 Gln Ser Asp Phe Gly Thr
Thr Ser Leu Lys Tyr Leu Asp Leu Ser Phe 355 360 365 aat ggt gtt att
acc atg agt tca aac ttc ttg ggc tta gaa caa cta 1152 Asn Gly Val
Ile Thr Met Ser Ser Asn Phe Leu Gly Leu Glu Gln Leu 370 375 380 gaa
cat ctg gat ttc cag cat tcc aat ttg aaa caa atg agt gag ttt 1200
Glu His Leu Asp Phe Gln His Ser Asn Leu Lys Gln Met Ser Glu Phe 385
390 395 400 tca gta ttc cta tca ctc aga aac ctc att tac ctt gac att
tct cat 1248 Ser Val Phe Leu Ser Leu Arg Asn Leu Ile Tyr Leu Asp
Ile Ser His 405 410 415 act cac acc aga gtt gct ttc aat ggc atc ttc
aat ggc ttg tcc agt 1296 Thr His Thr Arg Val Ala Phe Asn Gly Ile
Phe Asn Gly Leu Ser Ser 420 425 430 ctc gaa gtc ttg aaa atg gct ggc
aat tct ttc cag gaa aac ttc ctt 1344 Leu Glu Val Leu Lys Met Ala
Gly Asn Ser Phe Gln Glu Asn Phe Leu 435 440 445 cca gat atc ttc aca
gag ctg aga aac ttg acc ttc ctg gac ctc tct 1392 Pro Asp Ile Phe
Thr Glu Leu Arg Asn Leu Thr Phe Leu Asp Leu Ser 450 455 460 cag tgt
caa ctg gag cag ttg tct cca aca gca ttt aac tca ctc tcc 1440 Gln
Cys Gln Leu Glu Gln Leu Ser Pro Thr Ala Phe Asn Ser Leu Ser 465 470
475 480 agt ctt cag gta cta aat atg agc cac aac aac ttc ttt tca ttg
gat 1488 Ser Leu Gln Val Leu Asn Met Ser His Asn Asn Phe Phe Ser
Leu Asp 485 490 495 acg ttt cct tat aag tgt ctg aac tcc ctc cag gtt
ctt gat tac agt 1536 Thr Phe Pro Tyr Lys Cys Leu Asn Ser Leu Gln
Val Leu Asp Tyr Ser 500 505 510 ctc aat cac ata atg act tcc aaa aaa
cag gaa cta cag cat ttt cca 1584 Leu Asn His Ile Met Thr Ser Lys
Lys Gln Glu Leu Gln His Phe Pro 515 520 525 agt agt cta gct ttc tta
aat ctt act cag aat gac ttt gct tgt act 1632 Ser Ser Leu Ala Phe
Leu Asn Leu Thr Gln Asn Asp Phe Ala Cys Thr 530 535 540 tgt gaa cac
cag agt ttc ctg caa tgg atc aag gac cag agg cag ctc 1680 Cys Glu
His Gln Ser Phe Leu Gln Trp Ile Lys Asp Gln Arg Gln Leu 545 550 555
560 ttg gtg gaa gtt gaa cga atg gaa tgt gca aca cct tca gat aag cag
1728 Leu Val Glu Val Glu Arg Met Glu Cys Ala Thr Pro Ser Asp Lys
Gln 565 570 575 ggc atg cct gtg ctg agt ttg aat atc acc tgt cag atg
aat aag acc 1776 Gly Met Pro Val Leu Ser Leu Asn Ile Thr Cys Gln
Met Asn Lys Thr 580 585 590 atc att ggt gtg tcg gtc ctc agt gtg ctt
gta gta tct gtt gta gca 1824 Ile Ile Gly Val Ser Val Leu Ser Val
Leu Val Val Ser Val Val Ala 595 600 605 gtt ctg gtc tat aag ttc tat
ttt cac ctg atg ctt ctt gct ggc tgc 1872 Val Leu Val Tyr Lys Phe
Tyr Phe His Leu Met Leu Leu Ala Gly Cys 610 615 620 ata aag tat ggt
aga ggt gaa aac atc tat gat gcc ttt gtt atc tac 1920 Ile Lys Tyr
Gly Arg Gly Glu Asn Ile Tyr Asp Ala Phe Val Ile Tyr 625 630 635 640
tca agc cag gat gag gac tgg gta agg aat gag cta gta aag aat tta
1968 Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu Leu Val Lys Asn
Leu 645 650 655 gaa gaa ggg gtg cct cca ttt cag ctc tgc ctt cac tac
aga gac ttt 2016 Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu His
Tyr Arg Asp Phe 660 665 670 att ccc ggt gtg gcc att gct gcc aac atc
atc cat gaa ggt ttc cat 2064 Ile Pro Gly Val Ala Ile Ala Ala Asn
Ile Ile His Glu Gly Phe His 675 680 685 aaa agc cga aag gtg att gtt
gtg gtg tcc cag cac ttc atc cag agc 2112 Lys Ser Arg Lys Val Ile
Val Val Val Ser Gln His Phe Ile Gln Ser 690 695 700 cgc tgg tgt atc
ttt gaa tat gag att gct cag acc tgg cag ttt ctg 2160 Arg Trp Cys
Ile Phe Glu Tyr Glu Ile Ala Gln Thr Trp Gln Phe Leu 705 710 715 720
agc agt cgt gct ggt atc atc ttc att gtc ctg cag aag gtg gag aag
2208 Ser Ser Arg Ala Gly Ile Ile Phe Ile Val Leu Gln Lys Val Glu
Lys 725 730 735 acc ctg ctc agg cag cag gtg gag ctg tac cgc ctt ctc
agc agg aac 2256 Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg Leu
Leu Ser Arg Asn 740 745 750 act tac ctg gag tgg gag gac agt gtc ctg
ggg cgg cac atc ttc tgg 2304 Thr Tyr Leu Glu Trp Glu Asp Ser Val
Leu Gly Arg His Ile Phe Trp 755 760 765 aga cga ctc aga aaa gcc ctg
ctg gat ggt aaa tca tgg aat cca gaa 2352 Arg Arg Leu Arg Lys Ala
Leu Leu Asp Gly Lys Ser Trp Asn Pro Glu 770 775 780 gga aca gtg ggt
aca gga tgc aat tgg cag gaa gca aca tct atc tga 2400 Gly Thr Val
Gly Thr Gly Cys Asn Trp Gln Glu Ala Thr Ser Ile 785 790 795
<210> SEQ ID NO 8 <211> LENGTH: 799 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 8 Met
Glu Leu Asn Phe Tyr Lys Ile Pro Asp Asn Leu Pro Phe Ser Thr 1 5 10
15 Lys Asn Leu Asp Leu Ser Phe Asn Pro Leu Arg His Leu Gly Ser Tyr
20 25 30 Ser Phe Phe Ser Phe Pro Glu Leu Gln Val Leu Asp Leu Ser
Arg Cys 35 40 45 Glu Ile Gln Thr Ile Glu Asp Gly Ala Tyr Gln Ser
Leu Ser His Leu 50 55 60 Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile
Gln Ser Leu Ala Leu Gly 65 70 75 80 Ala Phe Ser Gly Leu Ser Ser Leu
Gln Lys Leu Val Ala Val Glu Thr 85 90 95 Asn Leu Ala Ser Leu Glu
Asn Phe Pro Ile Gly His Leu Lys Thr Leu 100 105 110 Lys Glu Leu Asn
Val Ala His Asn Leu Ile Gln Ser Phe Lys Leu Pro 115 120 125 Glu Tyr
Phe Ser Asn Leu Thr Asn Leu Glu His Leu Asp Leu Ser Ser 130 135 140
Asn Lys Ile Gln Ser Ile Tyr Cys Thr Asp Leu Arg Val Leu His Gln 145
150 155 160 Met Pro Leu Leu Asn Leu Ser Leu Asp Leu Ser Leu Asn Pro
Met Asn 165 170 175 Phe Ile Gln Pro Gly Ala Phe Lys Glu Ile Arg Leu
His Lys Leu Thr 180 185 190 Leu Arg Asn Asn Phe Asp Ser Leu Asn Val
Met Lys Thr Cys Ile Gln 195 200 205 Gly Leu Ala Gly Leu Glu Val His
Arg Leu Val Leu Gly Glu Phe Arg 210 215 220 Asn Glu Gly Asn Leu Glu
Lys Phe Asp Lys Ser Ala Leu Glu Gly Leu 225 230 235 240 Cys Asn Leu
Thr Ile Glu Glu Phe Arg Leu Ala Tyr Leu Asp Tyr Tyr 245 250 255 Leu
Asp Asp Ile Ile Asp Leu Phe Asn Cys Leu Thr Asn Val Ser Ser 260 265
270 Phe Ser Leu Val Ser Val Thr Ile Glu Arg Val Lys Asp Phe Ser Tyr
275 280 285 Asn Phe Gly Trp Gln His Leu Glu Leu Val Asn Cys Lys Phe
Gly Gln 290 295 300 Phe Pro Thr Leu Lys Leu Lys Ser Leu Lys Arg Leu
Thr Phe Thr Ser 305 310 315 320 Asn Lys Gly Gly Asn Ala Phe Ser Glu
Val Asp Leu Pro Ser Leu Glu 325 330 335 Phe Leu Asp Leu Ser Arg Asn
Gly Leu Ser Phe Lys Gly Cys Cys Ser 340 345 350 Gln Ser Asp Phe Gly
Thr Thr Ser Leu Lys Tyr Leu Asp Leu Ser Phe 355 360 365 Asn Gly Val
Ile Thr Met Ser Ser Asn Phe Leu Gly Leu Glu Gln Leu 370 375 380 Glu
His Leu Asp Phe Gln His Ser Asn Leu Lys Gln Met Ser Glu Phe 385 390
395 400 Ser Val Phe Leu Ser Leu Arg Asn Leu Ile Tyr Leu Asp Ile Ser
His 405 410 415 Thr His Thr Arg Val Ala Phe Asn Gly Ile Phe Asn Gly
Leu Ser Ser 420 425 430 Leu Glu Val Leu Lys Met Ala Gly Asn Ser Phe
Gln Glu Asn Phe Leu 435 440 445 Pro Asp Ile Phe Thr Glu Leu Arg Asn
Leu Thr Phe Leu Asp Leu Ser 450 455 460 Gln Cys Gln Leu Glu Gln Leu
Ser Pro Thr Ala Phe Asn Ser Leu Ser 465 470 475 480 Ser Leu Gln Val
Leu Asn Met Ser His Asn Asn Phe Phe Ser Leu Asp 485 490 495 Thr Phe
Pro Tyr Lys Cys Leu Asn Ser Leu Gln Val Leu Asp Tyr Ser 500 505 510
Leu Asn His Ile Met Thr Ser Lys Lys Gln Glu Leu Gln His Phe Pro 515
520 525 Ser Ser Leu Ala Phe Leu Asn Leu Thr Gln Asn Asp Phe Ala Cys
Thr 530 535 540 Cys Glu His Gln Ser Phe Leu Gln Trp Ile Lys Asp Gln
Arg Gln Leu 545 550 555 560 Leu Val Glu Val Glu Arg Met Glu Cys Ala
Thr Pro Ser Asp Lys Gln 565 570 575 Gly Met Pro Val Leu Ser Leu Asn
Ile Thr Cys Gln Met Asn Lys Thr 580 585 590 Ile Ile Gly Val Ser Val
Leu Ser Val Leu Val Val Ser Val Val Ala 595 600 605 Val Leu Val Tyr
Lys Phe Tyr Phe His Leu Met Leu Leu Ala Gly Cys 610 615 620 Ile Lys
Tyr Gly Arg Gly Glu Asn Ile Tyr Asp Ala Phe Val Ile Tyr 625 630 635
640 Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu Leu Val Lys Asn Leu
645 650 655 Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu His Tyr Arg
Asp Phe 660 665 670 Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile His
Glu Gly Phe His 675 680 685 Lys Ser Arg Lys Val Ile Val Val Val Ser
Gln His Phe Ile Gln Ser 690 695 700 Arg Trp Cys Ile Phe Glu Tyr Glu
Ile Ala Gln Thr Trp Gln Phe Leu 705 710 715 720 Ser Ser Arg Ala Gly
Ile Ile Phe Ile Val Leu Gln Lys Val Glu Lys 725 730 735 Thr Leu Leu
Arg Gln Gln Val Glu Leu Tyr Arg Leu Leu Ser Arg Asn 740 745 750 Thr
Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly Arg His Ile Phe Trp 755 760
765 Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly Lys Ser Trp Asn Pro Glu
770 775 780 Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu Ala Thr Ser
Ile 785 790 795 <210> SEQ ID NO 9 <211> LENGTH: 1275
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(1095) <400> SEQUENCE: 9 tgt tgg gat gtt ttt
gag gga ctt tct cat ctt caa gtt ctg tat ttg 48 Cys Trp Asp Val Phe
Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu 1 5 10 15 aat cat aac
tat ctt aat tcc ctt cca cca gga gta ttt agc cat ctg 96 Asn His Asn
Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu 20 25 30 act
gca tta agg gga cta agc ctc aac tcc aac agg ctg aca gtt ctt 144 Thr
Ala Leu Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu 35 40
45 tct cac aat gat tta cct gct aat tta gag atc ctg gac ata tcc agg
192 Ser His Asn Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg
50 55 60 aac cag ctc cta gct cct aat cct gat gta ttt gta tca ctt
agt gtc 240 Asn Gln Leu Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu
Ser Val 65 70 75 80 ttg gat ata act cat aac aag ttc att tgt gaa tgt
gaa ctt agc act 288 Leu Asp Ile Thr His Asn Lys Phe Ile Cys Glu Cys
Glu Leu Ser Thr 85 90 95 ttt atc aat tgg ctt aat cac acc aat gtc
act ata gct ggg cct cct 336 Phe Ile Asn Trp Leu Asn His Thr Asn Val
Thr Ile Ala Gly Pro Pro 100 105 110 gca gac ata tat tgt gtg tac cct
gac tcg ttc tct ggg gtt tcc ctc 384 Ala Asp Ile Tyr Cys Val Tyr Pro
Asp Ser Phe Ser Gly Val Ser Leu 115 120 125 ttc tct ctt tcc acg gaa
ggt tgt gat gaa gag gaa gtc tta aag tcc 432 Phe Ser Leu Ser Thr Glu
Gly Cys Asp Glu Glu Glu Val Leu Lys Ser 130 135 140 cta aag ttc tcc
ctt ttc att gta tgc act gtc act ctg act ctg ttc 480 Leu Lys Phe Ser
Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe 145 150 155 160 ctc
atg acc atc ctc aca gtc aca aag ttc cgg ggc ttc tgt ttt atc 528 Leu
Met Thr Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile 165 170
175 tgt tat aag aca gcc cag aga ctg gtg ttc aag gac cat ccc cag ggc
576 Cys Tyr Lys Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly
180 185 190 aca gaa cct gat atg tac aaa tat gat gcc tat ttg tgc ttc
agc agc 624 Thr Glu Pro Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe
Ser Ser 195 200 205 aaa gac ttc aca tgg gtg cag aat gct ttg ctc aaa
cac ctg gac act 672 Lys Asp Phe Thr Trp Val Gln Asn Ala Leu Leu Lys
His Leu Asp Thr 210 215 220 caa tac agt gac caa aac aga ttc aac ctg
tgc ttt gaa gaa aga gac 720 Gln Tyr Ser Asp Gln Asn Arg Phe Asn Leu
Cys Phe Glu Glu Arg Asp 225 230 235 240 ttt gtc cca gga gaa aac cgc
att gcc aat atc cag gat gcc atc tgg 768 Phe Val Pro Gly Glu Asn Arg
Ile Ala Asn Ile Gln Asp Ala Ile Trp 245 250 255 aac agt aga aag atc
gtt tgt ctt gtg agc aga cac ttc ctt aga gat 816 Asn Ser Arg Lys Ile
Val Cys Leu Val Ser Arg His Phe Leu Arg Asp 260 265 270 ggc tgg tgc
ctt gaa gcc ttc agt tat gcc cag ggc agg tgc tta tct 864 Gly Trp Cys
Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser 275 280 285 gac
ctt aac agt gct ctc atc atg gtg gtg gtt ggg tcc ttg tcc cag 912 Asp
Leu Asn Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln 290 295
300 tac cag ttg atg aaa cat caa tcc atc aga ggc ttt gta cag aaa cag
960 Tyr Gln Leu Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln
305 310 315 320 cag tat ttg agg tgg cct gag gat ctc cag gat gtt ggc
tgg ttt ctt 1008 Gln Tyr Leu Arg Trp Pro Glu Asp Leu Gln Asp Val
Gly Trp Phe Leu 325 330 335 cat aaa ctc tct caa cag ata cta aag aaa
gaa aag gaa aag aag aaa 1056 His Lys Leu Ser Gln Gln Ile Leu Lys
Lys Glu Lys Glu Lys Lys Lys 340 345 350 gac aat aac att ccg ttg caa
act gta gca acc atc tcc taatcaaagg 1105 Asp Asn Asn Ile Pro Leu Gln
Thr Val Ala Thr Ile Ser 355 360 365 agcaatttcc aacttatctc
aagccacaaa taactcttca ctttgtattt gcaccaagtt 1165 atcattttgg
ggtcctctct ggaggttttt tttttctttt tgctactatg aaaacaacat 1225
aaatctctca attttcgtat caaaaaaaaa aaaaaaaaaa tggcggccgc 1275
<210> SEQ ID NO 10 <211> LENGTH: 365 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 10 Cys
Trp Asp Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu 1 5 10
15 Asn His Asn Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu
20 25 30 Thr Ala Leu Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr
Val Leu 35 40 45 Ser His Asn Asp Leu Pro Ala Asn Leu Glu Ile Leu
Asp Ile Ser Arg 50 55 60 Asn Gln Leu Leu Ala Pro Asn Pro Asp Val
Phe Val Ser Leu Ser Val 65 70 75 80 Leu Asp Ile Thr His Asn Lys Phe
Ile Cys Glu Cys Glu Leu Ser Thr 85 90 95 Phe Ile Asn Trp Leu Asn
His Thr Asn Val Thr Ile Ala Gly Pro Pro 100 105 110 Ala Asp Ile Tyr
Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu 115 120 125 Phe Ser
Leu Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser 130 135 140
Leu Lys Phe Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe 145
150 155 160 Leu Met Thr Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys
Phe Ile 165 170 175 Cys Tyr Lys Thr Ala Gln Arg Leu Val Phe Lys Asp
His Pro Gln Gly 180 185 190 Thr Glu Pro Asp Met Tyr Lys Tyr Asp Ala
Tyr Leu Cys Phe Ser Ser 195 200 205 Lys Asp Phe Thr Trp Val Gln Asn
Ala Leu Leu Lys His Leu Asp Thr 210 215 220 Gln Tyr Ser Asp Gln Asn
Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp 225 230 235 240 Phe Val Pro
Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp 245 250 255 Asn
Ser Arg Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp 260 265
270 Gly Trp Cys Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser
275 280 285 Asp Leu Asn Ser Ala Leu Ile Met Val Val Val Gly Ser Leu
Ser Gln 290 295 300 Tyr Gln Leu Met Lys His Gln Ser Ile Arg Gly Phe
Val Gln Lys Gln 305 310 315 320 Gln Tyr Leu Arg Trp Pro Glu Asp Leu
Gln Asp Val Gly Trp Phe Leu 325 330 335 His Lys Leu Ser Gln Gln Ile
Leu Lys Lys Glu Lys Glu Lys Lys Lys 340 345 350 Asp Asn Asn Ile Pro
Leu Gln Thr Val Ala Thr Ile Ser 355 360 365 <210> SEQ ID NO
11 <211> LENGTH: 3138 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (1)..(3135) <400> SEQUENCE: 11 atg
tgg aca ctg aag aga cta att ctt atc ctt ttt aac ata atc cta 48 Met
Trp Thr Leu Lys Arg Leu Ile Leu Ile Leu Phe Asn Ile Ile Leu 1 5 10
15 att tcc aaa ctc ctt ggg gct aga tgg ttt cct aaa act ctg ccc tgt
96 Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys Thr Leu Pro Cys
20 25 30 gat gtc act ctg gat gtt cca aag aac cat gtg atc gtg gac
tgc aca 144 Asp Val Thr Leu Asp Val Pro Lys Asn His Val Ile Val Asp
Cys Thr 35 40 45 gac aag cat ttg aca gaa att cct gga ggt att ccc
acg aac acc acg 192 Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro
Thr Asn Thr Thr 50 55 60 aac ctc acc ctc acc att aac cac ata cca
gac atc tcc cca gcg tcc 240 Asn Leu Thr Leu Thr Ile Asn His Ile Pro
Asp Ile Ser Pro Ala Ser 65 70 75 80 ttt cac aga ctg gac cat ctg gta
gag atc gat ttc aga tgc aac tgt 288 Phe His Arg Leu Asp His Leu Val
Glu Ile Asp Phe Arg Cys Asn Cys 85 90 95 gta cct att cca ctg ggg
tca aaa aac aac atg tgc atc aag agg ctg 336 Val Pro Ile Pro Leu Gly
Ser Lys Asn Asn Met Cys Ile Lys Arg Leu 100 105 110 cag att aaa ccc
aga agc ttt agt gga ctc act tat tta aaa tcc ctt 384 Gln Ile Lys Pro
Arg Ser Phe Ser Gly Leu Thr Tyr Leu Lys Ser Leu 115 120 125 tac ctg
gat gga aac cag cta cta gag ata ccg cag ggc ctc ccg cct 432 Tyr Leu
Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln Gly Leu Pro Pro 130 135 140
agc tta cag ctt ctc agc ctt gag gcc aac aac atc ttt tcc atc aga 480
Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile Phe Ser Ile Arg 145
150 155 160 aaa gag aat cta aca gaa ctg gcc aac ata gaa ata ctc tac
ctg ggc 528 Lys Glu Asn Leu Thr Glu Leu Ala Asn Ile Glu Ile Leu Tyr
Leu Gly 165 170 175 caa aac tgt tat tat cga aat cct tgt tat gtt tca
tat tca ata gag 576 Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser
Tyr Ser Ile Glu 180 185 190 aaa gat gcc ttc cta aac ttg aca aag tta
aaa gtg ctc tcc ctg aaa 624 Lys Asp Ala Phe Leu Asn Leu Thr Lys Leu
Lys Val Leu Ser Leu Lys 195 200 205 gat aac aat gtc aca gcc gtc cct
act gtt ttg cca tct act tta aca 672 Asp Asn Asn Val Thr Ala Val Pro
Thr Val Leu Pro Ser Thr Leu Thr 210 215 220 gaa cta tat ctc tac aac
aac atg att gca aaa atc caa gaa gat gat 720 Glu Leu Tyr Leu Tyr Asn
Asn Met Ile Ala Lys Ile Gln Glu Asp Asp 225 230 235 240 ttt aat aac
ctc aac caa tta caa att ctt gac cta agt gga aat tgc 768 Phe Asn Asn
Leu Asn Gln Leu Gln Ile Leu Asp Leu Ser Gly Asn Cys 245 250 255 cct
cgt tgt tat aat gcc cca ttt cct tgt gcg ccg tgt aaa aat aat 816 Pro
Arg Cys Tyr Asn Ala Pro Phe Pro Cys Ala Pro Cys Lys Asn Asn 260 265
270 tct ccc cta cag atc cct gta aat gct ttt gat gcg ctg aca gaa tta
864 Ser Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala Leu Thr Glu Leu
275 280 285 aaa gtt tta cgt cta cac agt aac tct ctt cag cat gtg ccc
cca aga 912 Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His Val Pro
Pro Arg 290 295 300 tgg ttt aag aac atc aac aaa ctc cag gaa ctg gat
ctg tcc caa aac 960 Trp Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp
Leu Ser Gln Asn 305 310 315 320 ttc ttg gcc aaa gaa att ggg gat gct
aaa ttt ctg cat ttt ctc ccc 1008 Phe Leu Ala Lys Glu Ile Gly Asp
Ala Lys Phe Leu His Phe Leu Pro 325 330 335 agc ctc atc caa ttg gat
ctg tct ttc aat ttt gaa ctt cag gtc tat 1056 Ser Leu Ile Gln Leu
Asp Leu Ser Phe Asn Phe Glu Leu Gln Val Tyr 340 345 350 cgt gca tct
atg aat cta tca caa gca ttt tct tca ctg aaa agc ctg 1104 Arg Ala
Ser Met Asn Leu Ser Gln Ala Phe Ser Ser Leu Lys Ser Leu 355 360 365
aaa att ctg cgg atc aga gga tat gtc ttt aaa gag ttg aaa agc ttt
1152 Lys Ile Leu Arg Ile Arg Gly Tyr Val Phe Lys Glu Leu Lys Ser
Phe 370 375 380 aac ctc tcg cca tta cat aat ctt caa aat ctt gaa gtt
ctt gat ctt 1200 Asn Leu Ser Pro Leu His Asn Leu Gln Asn Leu Glu
Val Leu Asp Leu 385 390 395 400 ggc act aac ttt ata aaa att gct aac
ctc agc atg ttt aaa caa ttt 1248 Gly Thr Asn Phe Ile Lys Ile Ala
Asn Leu Ser Met Phe Lys Gln Phe 405 410 415 aaa aga ctg aaa gtc ata
gat ctt tca gtg aat aaa ata tca cct tca 1296 Lys Arg Leu Lys Val
Ile Asp Leu Ser Val Asn Lys Ile Ser Pro Ser 420 425 430 gga gat tca
agt gaa gtt ggc ttc tgc tca aat gcc aga act tct gta 1344 Gly Asp
Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg Thr Ser Val 435 440 445
gaa agt tat gaa ccc cag gtc ctg gaa caa tta cat tat ttc aga tat
1392 Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His Tyr Phe Arg
Tyr 450 455 460 gat aag tat gca agg agt tgc aga ttc aaa aac aaa gag
gct tct ttc 1440 Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys
Glu Ala Ser Phe 465 470 475 480 atg tct gtt aat gaa agc tgc tac aag
tat ggg cag acc ttg gat cta 1488 Met Ser Val Asn Glu Ser Cys Tyr
Lys Tyr Gly Gln Thr Leu Asp Leu 485 490 495 agt aaa aat agt ata ttt
ttt gtc aag tcc tct gat ttt cag cat ctt 1536 Ser Lys Asn Ser Ile
Phe Phe Val Lys Ser Ser Asp Phe Gln His Leu 500 505 510 tct ttc ctc
aaa tgc ctg aat ctg tca gga aat ctc att agc caa act 1584 Ser Phe
Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu Ile Ser Gln Thr 515 520 525
ctt aat ggc agt gaa ttc caa cct tta gca gag ctg aga tat ttg gac
1632 Leu Asn Gly Ser Glu Phe Gln Pro Leu Ala Glu Leu Arg Tyr Leu
Asp 530 535 540 ttc tcc aac aac cgg ctt gat tta ctc cat tca aca gca
ttt gaa gag 1680 Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr
Ala Phe Glu Glu 545 550 555 560 ctt cac aaa ctg gaa gtt ctg gat ata
agc agt aat agc cat tat ttt 1728 Leu His Lys Leu Glu Val Leu Asp
Ile Ser Ser Asn Ser His Tyr Phe 565 570 575 caa tca gaa gga att act
cat atg cta aac ttt acc aag aac cta aag 1776 Gln Ser Glu Gly Ile
Thr His Met Leu Asn Phe Thr Lys Asn Leu Lys 580 585 590 gtt ctg cag
aaa ctg atg atg aac gac aat gac atc tct tcc tcc acc 1824 Val Leu
Gln Lys Leu Met Met Asn Asp Asn Asp Ile Ser Ser Ser Thr 595 600 605
agc agg acc atg gag agt gag tct ctt aga act ctg gaa ttc aga gga
1872 Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Thr Leu Glu Phe Arg
Gly 610 615 620 aat cac tta gat gtt tta tgg aga gaa ggt gat aac aga
tac tta caa 1920 Asn His Leu Asp Val Leu Trp Arg Glu Gly Asp Asn
Arg Tyr Leu Gln 625 630 635 640 tta ttc aag aat ctg cta aaa tta gag
gaa tta gac atc tct aaa aat 1968 Leu Phe Lys Asn Leu Leu Lys Leu
Glu Glu Leu Asp Ile Ser Lys Asn 645 650 655 tcc cta agt ttc ttg cct
tct gga gtt ttt gat ggt atg cct cca aat 2016 Ser Leu Ser Phe Leu
Pro Ser Gly Val Phe Asp Gly Met Pro Pro Asn 660 665 670 cta aag aat
ctc tct ttg gcc aaa aat ggg ctc aaa tct ttc agt tgg 2064 Leu Lys
Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys Ser Phe Ser Trp 675 680 685
aag aaa ctc cag tgt cta aag aac ctg gaa act ttg gac ctc agc cac
2112 Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu Asp Leu Ser
His 690 695 700 aac caa ctg acc act gtc cct gag aga tta tcc aac tgt
tcc aga agc 2160 Asn Gln Leu Thr Thr Val Pro Glu Arg Leu Ser Asn
Cys Ser Arg Ser 705 710 715 720 ctc aag aat ctg att ctt aag aat aat
caa atc agg agt ctg acg aag 2208 Leu Lys Asn Leu Ile Leu Lys Asn
Asn Gln Ile Arg Ser Leu Thr Lys 725 730 735 tat ttt cta caa gat gcc
ttc cag ttg cga tat ctg gat ctc agc tca 2256 Tyr Phe Leu Gln Asp
Ala Phe Gln Leu Arg Tyr Leu Asp Leu Ser Ser 740 745 750 aat aaa atc
cag atg atc caa aag acc agc ttc cca gaa aat gtc ctc 2304 Asn Lys
Ile Gln Met Ile Gln Lys Thr Ser Phe Pro Glu Asn Val Leu 755 760 765
aac aat ctg aag atg ttg ctt ttg cat cat aat cgg ttt ctg tgc acc
2352 Asn Asn Leu Lys Met Leu Leu Leu His His Asn Arg Phe Leu Cys
Thr 770 775 780 tgt gat gct gtg tgg ttt gtc tgg tgg gtt aac cat acg
gag gtg act 2400 Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn His
Thr Glu Val Thr 785 790 795 800 att cct tac ctg gcc aca gat gtg act
tgt gtg ggg cca gga gca cac 2448 Ile Pro Tyr Leu Ala Thr Asp Val
Thr Cys Val Gly Pro Gly Ala His 805 810 815 aag ggc caa agt gtg atc
tcc ctg gat ctg tac acc tgt gag tta gat 2496 Lys Gly Gln Ser Val
Ile Ser Leu Asp Leu Tyr Thr Cys Glu Leu Asp 820 825 830 ctg act aac
ctg att ctg ttc tca ctt tcc ata tct gta tct ctc ttt 2544 Leu Thr
Asn Leu Ile Leu Phe Ser Leu Ser Ile Ser Val Ser Leu Phe 835 840 845
ctc atg gtg atg atg aca gca agt cac ctc tat ttc tgg gat gtg tgg
2592 Leu Met Val Met Met Thr Ala Ser His Leu Tyr Phe Trp Asp Val
Trp 850 855 860 tat att tac cat ttc tgt aag gcc aag ata aag ggg tat
cag cgt cta 2640 Tyr Ile Tyr His Phe Cys Lys Ala Lys Ile Lys Gly
Tyr Gln Arg Leu 865 870 875 880 ata tca cca gac tgt tgc tat gat gct
ttt att gtg tat gac act aaa 2688 Ile Ser Pro Asp Cys Cys Tyr Asp
Ala Phe Ile Val Tyr Asp Thr Lys 885 890 895 gac cca gct gtg acc gag
tgg gtt ttg gct gag ctg gtg gcc aaa ctg 2736 Asp Pro Ala Val Thr
Glu Trp Val Leu Ala Glu Leu Val Ala Lys Leu 900 905 910 gaa gac cca
aga gag aaa cat ttt aat tta tgt ctc gag gaa agg gac 2784 Glu Asp
Pro Arg Glu Lys His Phe Asn Leu Cys Leu Glu Glu Arg Asp 915 920 925
tgg tta cca ggg cag cca gtt ctg gaa aac ctt tcc cag agc ata cag
2832 Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser Gln Ser Ile
Gln 930 935 940 ctt agc aaa aag aca gtg ttt gtg atg aca gac aag tat
gca aag act 2880 Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys
Tyr Ala Lys Thr 945 950 955 960 gaa aat ttt aag ata gca ttt tac ttg
tcc cat cag agg ctc atg gat 2928 Glu Asn Phe Lys Ile Ala Phe Tyr
Leu Ser His Gln Arg Leu Met Asp 965 970 975 gaa aaa gtt gat gtg att
atc ttg ata ttt ctt gag aag ccc ttt cag 2976 Glu Lys Val Asp Val
Ile Ile Leu Ile Phe Leu Glu Lys Pro Phe Gln 980 985 990 aag tcc aag
ttc ctc cag ctc cgg aaa agg ctc tgt ggg agt tct gtc 3024 Lys Ser
Lys Phe Leu Gln Leu Arg Lys Arg Leu Cys Gly Ser Ser Val 995 1000
1005 ctt gag tgg cca aca aac ccg caa gct cac cca tac ttc tgg cag
3069 Leu Glu Trp Pro Thr Asn Pro Gln Ala His Pro Tyr Phe Trp Gln
1010 1015 1020 tgt cta aag aac gcc ctg gcc aca gac aat cat gtg gcc
tat agt 3114 Cys Leu Lys Asn Ala Leu Ala Thr Asp Asn His Val Ala
Tyr Ser 1025 1030 1035 cag gtg ttc aag gaa acg gtc tag 3138 Gln Val
Phe Lys Glu Thr Val 1040 1045 <210> SEQ ID NO 12 <211>
LENGTH: 1045 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 12 Met Trp Thr Leu Lys Arg Leu Ile
Leu Ile Leu Phe Asn Ile Ile Leu 1 5 10 15 Ile Ser Lys Leu Leu Gly
Ala Arg Trp Phe Pro Lys Thr Leu Pro Cys 20 25 30 Asp Val Thr Leu
Asp Val Pro Lys Asn His Val Ile Val Asp Cys Thr 35 40 45 Asp Lys
His Leu Thr Glu Ile Pro Gly Gly Ile Pro Thr Asn Thr Thr 50 55 60
Asn Leu Thr Leu Thr Ile Asn His Ile Pro Asp Ile Ser Pro Ala Ser 65
70 75 80 Phe His Arg Leu Asp His Leu Val Glu Ile Asp Phe Arg Cys
Asn Cys 85 90 95 Val Pro Ile Pro Leu Gly Ser Lys Asn Asn Met Cys
Ile Lys Arg Leu 100 105 110 Gln Ile Lys Pro Arg Ser Phe Ser Gly Leu
Thr Tyr Leu Lys Ser Leu 115 120 125 Tyr Leu Asp Gly Asn Gln Leu Leu
Glu Ile Pro Gln Gly Leu Pro Pro 130 135 140 Ser Leu Gln Leu Leu Ser
Leu Glu Ala Asn Asn Ile Phe Ser Ile Arg 145 150 155 160 Lys Glu Asn
Leu Thr Glu Leu Ala Asn Ile Glu Ile Leu Tyr Leu Gly 165 170 175 Gln
Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser Tyr Ser Ile Glu 180 185
190 Lys Asp Ala Phe Leu Asn Leu Thr Lys Leu Lys Val Leu Ser Leu Lys
195 200 205 Asp Asn Asn Val Thr Ala Val Pro Thr Val Leu Pro Ser Thr
Leu Thr 210 215 220 Glu Leu Tyr Leu Tyr Asn Asn Met Ile Ala Lys Ile
Gln Glu Asp Asp 225 230 235 240 Phe Asn Asn Leu Asn Gln Leu Gln Ile
Leu Asp Leu Ser Gly Asn Cys 245 250 255 Pro Arg Cys Tyr Asn Ala Pro
Phe Pro Cys Ala Pro Cys Lys Asn Asn 260 265 270 Ser Pro Leu Gln Ile
Pro Val Asn Ala Phe Asp Ala Leu Thr Glu Leu 275 280 285 Lys Val Leu
Arg Leu His Ser Asn Ser Leu Gln His Val Pro Pro Arg 290 295 300 Trp
Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp Leu Ser Gln Asn 305 310
315 320 Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe Leu His Phe Leu
Pro 325 330 335 Ser Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe Glu Leu
Gln Val Tyr 340 345 350 Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser
Ser Leu Lys Ser Leu 355 360 365 Lys Ile Leu Arg Ile Arg Gly Tyr Val
Phe Lys Glu Leu Lys Ser Phe 370 375 380 Asn Leu Ser Pro Leu His Asn
Leu Gln Asn Leu Glu Val Leu Asp Leu 385 390 395 400 Gly Thr Asn Phe
Ile Lys Ile Ala Asn Leu Ser Met Phe Lys Gln Phe 405 410 415 Lys Arg
Leu Lys Val Ile Asp Leu Ser Val Asn Lys Ile Ser Pro Ser 420 425 430
Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg Thr Ser Val 435
440 445 Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His Tyr Phe Arg
Tyr 450 455 460 Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys Glu
Ala Ser Phe 465 470 475 480 Met Ser Val Asn Glu Ser Cys Tyr Lys Tyr
Gly Gln Thr Leu Asp Leu 485 490 495 Ser Lys Asn Ser Ile Phe Phe Val
Lys Ser Ser Asp Phe Gln His Leu 500 505 510 Ser Phe Leu Lys Cys Leu
Asn Leu Ser Gly Asn Leu Ile Ser Gln Thr 515 520 525 Leu Asn Gly Ser
Glu Phe Gln Pro Leu Ala Glu Leu Arg Tyr Leu Asp 530 535 540 Phe Ser
Asn Asn Arg Leu Asp Leu Leu His Ser Thr Ala Phe Glu Glu 545 550 555
560 Leu His Lys Leu Glu Val Leu Asp Ile Ser Ser Asn Ser His Tyr Phe
565 570 575 Gln Ser Glu Gly Ile Thr His Met Leu Asn Phe Thr Lys Asn
Leu Lys 580 585 590 Val Leu Gln Lys Leu Met Met Asn Asp Asn Asp Ile
Ser Ser Ser Thr 595 600 605 Ser Arg Thr Met Glu Ser Glu Ser Leu Arg
Thr Leu Glu Phe Arg Gly 610 615 620 Asn His Leu Asp Val Leu Trp Arg
Glu Gly Asp Asn Arg Tyr Leu Gln 625 630 635 640 Leu Phe Lys Asn Leu
Leu Lys Leu Glu Glu Leu Asp Ile Ser Lys Asn 645 650 655 Ser Leu Ser
Phe Leu Pro Ser Gly Val Phe Asp Gly Met Pro Pro Asn 660 665 670 Leu
Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys Ser Phe Ser Trp 675 680
685 Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu Asp Leu Ser His
690 695 700 Asn Gln Leu Thr Thr Val Pro Glu Arg Leu Ser Asn Cys Ser
Arg Ser 705 710 715 720 Leu Lys Asn Leu Ile Leu Lys Asn Asn Gln Ile
Arg Ser Leu Thr Lys 725 730 735 Tyr Phe Leu Gln Asp Ala Phe Gln Leu
Arg Tyr Leu Asp Leu Ser Ser 740 745 750 Asn Lys Ile Gln Met Ile Gln
Lys Thr Ser Phe Pro Glu Asn Val Leu 755 760 765 Asn Asn Leu Lys Met
Leu Leu Leu His His Asn Arg Phe Leu Cys Thr 770 775 780 Cys Asp Ala
Val Trp Phe Val Trp Trp Val Asn His Thr Glu Val Thr 785 790 795 800
Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly Pro Gly Ala His 805
810 815 Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr Cys Glu Leu
Asp 820 825 830 Leu Thr Asn Leu Ile Leu Phe Ser Leu Ser Ile Ser Val
Ser Leu Phe 835 840 845 Leu Met Val Met Met Thr Ala Ser His Leu Tyr
Phe Trp Asp Val Trp 850 855 860 Tyr Ile Tyr His Phe Cys Lys Ala Lys
Ile Lys Gly Tyr Gln Arg Leu 865 870 875 880 Ile Ser Pro Asp Cys Cys
Tyr Asp Ala Phe Ile Val Tyr Asp Thr Lys 885 890 895 Asp Pro Ala Val
Thr Glu Trp Val Leu Ala Glu Leu Val Ala Lys Leu 900 905 910 Glu Asp
Pro Arg Glu Lys His Phe Asn Leu Cys Leu Glu Glu Arg Asp 915 920 925
Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser Gln Ser Ile Gln 930
935 940 Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys Tyr Ala Lys
Thr 945 950 955 960 Glu Asn Phe Lys Ile Ala Phe Tyr Leu Ser His Gln
Arg Leu Met Asp 965 970 975 Glu Lys Val Asp Val Ile Ile Leu Ile Phe
Leu Glu Lys Pro Phe Gln 980 985 990 Lys Ser Lys Phe Leu Gln Leu Arg
Lys Arg Leu Cys Gly Ser Ser Val 995 1000 1005 Leu Glu Trp Pro Thr
Asn Pro Gln Ala His Pro Tyr Phe Trp Gln 1010 1015 1020 Cys Leu Lys
Asn Ala Leu Ala Thr Asp Asn His Val Ala Tyr Ser 1025 1030 1035 Gln
Val Phe Lys Glu Thr Val 1040 1045 <210> SEQ ID NO 13
<211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM:
Mus musculus <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(177) <400> SEQUENCE: 13 ctt gga
aaa cct ctt cag aag tct aag ttt ctt cag ctc agg aag aga 48 Leu Gly
Lys Pro Leu Gln Lys Ser Lys Phe Leu Gln Leu Arg Lys Arg 1 5 10 15
ctc tgc agg agc tct gtc ctt gag tgg cct gca aat cca cag gct cac 96
Leu Cys Arg Ser Ser Val Leu Glu Trp Pro Ala Asn Pro Gln Ala His 20
25 30 cca tac ttc tgg cag tgc ctg aaa aat gcc ctg acc aca gac aat
cat 144 Pro Tyr Phe Trp Gln Cys Leu Lys Asn Ala Leu Thr Thr Asp Asn
His 35 40 45 gtg gct tat agt caa atg ttc aag gaa aca gtc tag 180
Val Ala Tyr Ser Gln Met Phe Lys Glu Thr Val 50 55 <210> SEQ
ID NO 14 <211> LENGTH: 59 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 14 Leu Gly Lys Pro Leu
Gln Lys Ser Lys Phe Leu Gln Leu Arg Lys Arg 1 5 10 15 Leu Cys Arg
Ser Ser Val Leu Glu Trp Pro Ala Asn Pro Gln Ala His 20 25 30 Pro
Tyr Phe Trp Gln Cys Leu Lys Asn Ala Leu Thr Thr Asp Asn His 35 40
45 Val Ala Tyr Ser Gln Met Phe Lys Glu Thr Val 50 55 <210>
SEQ ID NO 15 <211> LENGTH: 990 <212> TYPE: DNA
<213> ORGANISM: Homo sapiens <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (2)..(988) <400>
SEQUENCE: 15 g aat tcc aga ctt ata aac ttg aaa aat ctc tat ttg gcc
tgg aac tgc 49 Asn Ser Arg Leu Ile Asn Leu Lys Asn Leu Tyr Leu Ala
Trp Asn Cys 1 5 10 15 tat ttt aac aaa gtt tgc gag aaa act aac ata
gaa gat gga gta ttt 97 Tyr Phe Asn Lys Val Cys Glu Lys Thr Asn Ile
Glu Asp Gly Val Phe 20 25 30 gaa acg ctg aca aat ttg gag ttg cta
tca cta tct ttc aat tct ctt 145 Glu Thr Leu Thr Asn Leu Glu Leu Leu
Ser Leu Ser Phe Asn Ser Leu 35 40 45 tca cat gtg cca ccc aaa ctg
cca agc tcc cta cgc aaa ctt ttt ctg 193 Ser His Val Pro Pro Lys Leu
Pro Ser Ser Leu Arg Lys Leu Phe Leu 50 55 60 agc aac acc cag atc
aaa tac att agt gaa gaa gat ttc aag gga ttg 241 Ser Asn Thr Gln Ile
Lys Tyr Ile Ser Glu Glu Asp Phe Lys Gly Leu 65 70 75 80 ata aat tta
aca tta cta gat tta agc ggg aac tgt ccg agg tgc ttc 289 Ile Asn Leu
Thr Leu Leu Asp Leu Ser Gly Asn Cys Pro Arg Cys Phe 85 90 95 aat
gcc cca ttt cca tgc gtg cct tgt gat ggt ggt gct tca att aat 337 Asn
Ala Pro Phe Pro Cys Val Pro Cys Asp Gly Gly Ala Ser Ile Asn 100 105
110 ata gat cgt ttt gct ttt caa aac ttg acc caa ctt cga tac cta aac
385 Ile Asp Arg Phe Ala Phe Gln Asn Leu Thr Gln Leu Arg Tyr Leu Asn
115 120 125 ctc tct agc act tcc ctc agg aag att aat gct gcc tgg ttt
aaa aat 433 Leu Ser Ser Thr Ser Leu Arg Lys Ile Asn Ala Ala Trp Phe
Lys Asn 130 135 140 atg cct cat ctg aag gtg ctg gat ctt gaa ttc aac
tat tta gtg gga 481 Met Pro His Leu Lys Val Leu Asp Leu Glu Phe Asn
Tyr Leu Val Gly 145 150 155 160 gaa ata gcc tct ggg gca ttt tta acg
atg ctg ccc cgc tta gaa ata 529 Glu Ile Ala Ser Gly Ala Phe Leu Thr
Met Leu Pro Arg Leu Glu Ile 165 170 175 ctt gac ttg tct ttt aac tat
ata aag ggg agt tat cca cag cat att 577 Leu Asp Leu Ser Phe Asn Tyr
Ile Lys Gly Ser Tyr Pro Gln His Ile 180 185 190 aat att tcc aga aac
ttc tct aaa ctt ttg tct cta cgg gca ttg cat 625 Asn Ile Ser Arg Asn
Phe Ser Lys Leu Leu Ser Leu Arg Ala Leu His 195 200 205 tta aga ggt
tat gtg ttc cag gaa ctc aga gaa gat gat ttc cag ccc 673 Leu Arg Gly
Tyr Val Phe Gln Glu Leu Arg Glu Asp Asp Phe Gln Pro 210 215 220 ctg
atg cag ctt cca aac tta tcg act atc aac ttg ggt att aat ttt 721 Leu
Met Gln Leu Pro Asn Leu Ser Thr Ile Asn Leu Gly Ile Asn Phe 225 230
235 240 att aag caa atc gat ttc aaa ctt ttc caa aat ttc tcc aat ctg
gaa 769 Ile Lys Gln Ile Asp Phe Lys Leu Phe Gln Asn Phe Ser Asn Leu
Glu 245 250 255 att att tac ttg tca gaa aac aga ata tca ccg ttg gta
aaa gat acc 817 Ile Ile Tyr Leu Ser Glu Asn Arg Ile Ser Pro Leu Val
Lys Asp Thr 260 265 270 cgg cag agt tat gca aat agt tcc tct ttt caa
cgt cat atc cgg aaa 865 Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln
Arg His Ile Arg Lys 275 280 285 cga cgc tca aca gat ttt gag ttt gac
cca cat tcg aac ttt tat cat 913 Arg Arg Ser Thr Asp Phe Glu Phe Asp
Pro His Ser Asn Phe Tyr His 290 295 300 ttc acc cgt cct tta ata aag
cca caa tgt gct gct tat gga aaa gcc 961 Phe Thr Arg Pro Leu Ile Lys
Pro Gln Cys Ala Ala Tyr Gly Lys Ala 305 310 315 320 tta gat tta agc
ctc aac agt att ttc tt 990 Leu Asp Leu Ser Leu Asn Ser Ile Phe 325
<210> SEQ ID NO 16 <211> LENGTH: 329 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 16 Asn
Ser Arg Leu Ile Asn Leu Lys Asn Leu Tyr Leu Ala Trp Asn Cys 1 5 10
15 Tyr Phe Asn Lys Val Cys Glu Lys Thr Asn Ile Glu Asp Gly Val Phe
20 25 30 Glu Thr Leu Thr Asn Leu Glu Leu Leu Ser Leu Ser Phe Asn
Ser Leu 35 40 45 Ser His Val Pro Pro Lys Leu Pro Ser Ser Leu Arg
Lys Leu Phe Leu 50 55 60 Ser Asn Thr Gln Ile Lys Tyr Ile Ser Glu
Glu Asp Phe Lys Gly Leu 65 70 75 80 Ile Asn Leu Thr Leu Leu Asp Leu
Ser Gly Asn Cys Pro Arg Cys Phe 85 90 95 Asn Ala Pro Phe Pro Cys
Val Pro Cys Asp Gly Gly Ala Ser Ile Asn 100 105 110 Ile Asp Arg Phe
Ala Phe Gln Asn Leu Thr Gln Leu Arg Tyr Leu Asn 115 120 125 Leu Ser
Ser Thr Ser Leu Arg Lys Ile Asn Ala Ala Trp Phe Lys Asn 130 135 140
Met Pro His Leu Lys Val Leu Asp Leu Glu Phe Asn Tyr Leu Val Gly 145
150 155 160 Glu Ile Ala Ser Gly Ala Phe Leu Thr Met Leu Pro Arg Leu
Glu Ile 165 170 175 Leu Asp Leu Ser Phe Asn Tyr Ile Lys Gly Ser Tyr
Pro Gln His Ile 180 185 190 Asn Ile Ser Arg Asn Phe Ser Lys Leu Leu
Ser Leu Arg Ala Leu His 195 200 205 Leu Arg Gly Tyr Val Phe Gln Glu
Leu Arg Glu Asp Asp Phe Gln Pro 210 215 220 Leu Met Gln Leu Pro Asn
Leu Ser Thr Ile Asn Leu Gly Ile Asn Phe 225 230 235 240 Ile Lys Gln
Ile Asp Phe Lys Leu Phe Gln Asn Phe Ser Asn Leu Glu 245 250 255 Ile
Ile Tyr Leu Ser Glu Asn Arg Ile Ser Pro Leu Val Lys Asp Thr 260 265
270 Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys
275 280 285 Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His Ser Asn Phe
Tyr His 290 295 300 Phe Thr Arg Pro Leu Ile Lys Pro Gln Cys Ala Ala
Tyr Gly Lys Ala 305 310 315 320 Leu Asp Leu Ser Leu Asn Ser Ile Phe
325 <210> SEQ ID NO 17 <211> LENGTH: 1543 <212>
TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(513)
<220> FEATURE: <221> NAME/KEY: modified_base
<222> LOCATION: (277)..(279) <223> OTHER INFORMATION:
Position 278 may be c or g, and this codon may encode Gly or Ala
<220> FEATURE: <221> NAME/KEY: modified_base
<222> LOCATION: (445)..(447) <223> OTHER INFORMATION:
Position 446 may be a or t, and this codon may encode Arg
<400> SEQUENCE: 17 cag tct ctt tcc aca tcc caa act ttc tat
gat gct tac att tct tat 48 Gln Ser Leu Ser Thr Ser Gln Thr Phe Tyr
Asp Ala Tyr Ile Ser Tyr 1 5 10 15 gac acc aaa gat gcc tct gtt act
gac tgg gtg ata aat gag ctg cgc 96 Asp Thr Lys Asp Ala Ser Val Thr
Asp Trp Val Ile Asn Glu Leu Arg 20 25 30 tac cac ctt gaa gag agc
cga gac aaa aac gtt ctc ctt tgt cta gag 144 Tyr His Leu Glu Glu Ser
Arg Asp Lys Asn Val Leu Leu Cys Leu Glu 35 40 45 gag agg gat tgg
gac ccg gga ttg gcc atc atc gac aac ctc atg cag 192 Glu Arg Asp Trp
Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln 50 55 60 agc atc
aac caa agc aag aaa aca gta ttt gtt tta acc aaa aaa tat 240 Ser Ile
Asn Gln Ser Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr 65 70 75 80
gca aaa agc tgg aac ttt aaa aca gct ttt tac ttg gsc ttg cag agg 288
Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr Leu Xaa Leu Gln Arg 85
90 95 cta atg ggt gag aac atg gat gtg att ata ttt atc ctg ctg gag
cca 336 Leu Met Gly Glu Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu
Pro 100 105 110 gtg tta cag cat tct ccg tat ttg agg cta cgg cag cgg
atc tgt aag 384 Val Leu Gln His Ser Pro Tyr Leu Arg Leu Arg Gln Arg
Ile Cys Lys 115 120 125 agc tcc atc ctc cag tgg cct gac aac ccg aag
gca gaa agg ttg ttt 432 Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys
Ala Glu Arg Leu Phe 130 135 140 tgg caa act ctg wga aat gtg gtc ttg
act gaa aat gat tca cgg tat 480 Trp Gln Thr Leu Xaa Asn Val Val Leu
Thr Glu Asn Asp Ser Arg Tyr 145 150 155 160 aac aat atg tat gtc gat
tcc att aag caa tac taactgacgt taagtcatga 533 Asn Asn Met Tyr Val
Asp Ser Ile Lys Gln Tyr 165 170 tttcgcgcca taataaagat gcaaaggaat
gacatttcgt attagttatc tattgctagg 593 taacaaatta tcccaaaaac
ttagtggttt aaaacaacac atttgctggc ccacagtttt 653 tgagggtcag
gagtccaggc ccagcataac tgggtcttct gcttcagggt gtctcagagg 713
ctgcaatgta ggtgttcacc agagacatag gcatcactgg ggtcacactc atgtggttgt
773 tttctggatt caattcctcc tgggctattg gccaaaggct atactcatgt
aagccatgcg 833 agcctatccc acaaggcagc ttgcttcatc agagctagca
aaaaagagag gttgctagca 893 agatgaagtc acaatctttt gtaatcgaat
caaaaaagtg atatctcatc actttggcca 953 tattctattt gttagaagta
aaccacaggt cccaccagct ccatgggagt gaccacctca 1013 gtccagggaa
aacagctgaa gaccaagatg gtgagctctg attgcttcag ttggtcatca 1073
actattttcc cttgactgct gtcctgggat ggccggctat cttgatggat agattgtgaa
1133 tatcaggagg ccagggatca ctgtggacca tcttagcagt tgacctaaca
catcttcttt 1193 tcaatatcta agaacttttg ccactgtgac taatggtcct
aatattaagc tgttgtttat 1253 atttatcata tatctatggc tacatggtta
tattatgctg tggttgcgtt cggttttatt 1313 tacagttgct tttacaaata
tttgctgtaa catttgactt ctaaggttta gatgccattt 1373 aagaactgag
atggatagct tttaaagcat cttttacttc ttaccatttt ttaaaagtat 1433
gcagctaaat tcgaagcttt tggtctatat tgttaattgc cattgctgta aatcttaaaa
1493 tgaatgaata aaaatgtttc attttaaaaa aaaaaaaaaa aaaaaaaaaa 1543
<210> SEQ ID NO 18 <211> LENGTH: 171 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (93)..(93)
<223> OTHER INFORMATION: Gly or Ala <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (149)..(149)
<223> OTHER INFORMATION: Arg or not present <400>
SEQUENCE: 18 Gln Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp Ala Tyr
Ile Ser Tyr 1 5 10 15 Asp Thr Lys Asp Ala Ser Val Thr Asp Trp Val
Ile Asn Glu Leu Arg 20 25 30 Tyr His Leu Glu Glu Ser Arg Asp Lys
Asn Val Leu Leu Cys Leu Glu 35 40 45 Glu Arg Asp Trp Asp Pro Gly
Leu Ala Ile Ile Asp Asn Leu Met Gln 50 55 60 Ser Ile Asn Gln Ser
Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr 65 70 75 80 Ala Lys Ser
Trp Asn Phe Lys Thr Ala Phe Tyr Leu Xaa Leu Gln Arg 85 90 95 Leu
Met Gly Glu Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu Pro 100 105
110 Val Leu Gln His Ser Pro Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys
115 120 125 Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys Ala Glu Arg
Leu Phe 130 135 140 Trp Gln Thr Leu Xaa Asn Val Val Leu Thr Glu Asn
Asp Ser Arg Tyr 145 150 155 160 Asn Asn Met Tyr Val Asp Ser Ile Lys
Gln Tyr 165 170 <210> SEQ ID NO 19 <211> LENGTH: 629
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(486) <220> FEATURE: <221> NAME/KEY:
modified_base <222> LOCATION: (142)..(144) <223> OTHER
INFORMATION: Position 144 may be c or t, and this codon encodes Ser
<400> SEQUENCE: 19 aat gaa ttg atc ccc aat cta gag aag gaa
gat ggt tct atc ttg att 48 Asn Glu Leu Ile Pro Asn Leu Glu Lys Glu
Asp Gly Ser Ile Leu Ile 1 5 10 15 tgc ctt tat gaa agc tac ttt gac
cct ggc aaa agc att agt gaa aat 96 Cys Leu Tyr Glu Ser Tyr Phe Asp
Pro Gly Lys Ser Ile Ser Glu Asn 20 25 30 att gta agc ttc att gag
aaa agc tat aag tcc atc ttt gtt ttg tcy 144 Ile Val Ser Phe Ile Glu
Lys Ser Tyr Lys Ser Ile Phe Val Leu Xaa 35 40 45 ccc aac ttt gtc
cag aat gag tgg tgc cat tat gaa ttc tac ttt gcc 192 Pro Asn Phe Val
Gln Asn Glu Trp Cys His Tyr Glu Phe Tyr Phe Ala 50 55 60 cac cac
aat ctc ttc cat gaa aat tct gat cay ata att ctt atc tta 240 His His
Asn Leu Phe His Glu Asn Ser Asp His Ile Ile Leu Ile Leu 65 70 75 80
ctg gaa ccc att cca ttc tat tgc att ccc acc agg tat cat aaa ctg 288
Leu Glu Pro Ile Pro Phe Tyr Cys Ile Pro Thr Arg Tyr His Lys Leu 85
90 95 gaa gct ctc ctg gaa aaa aaa gca tac ttg gaa tgg ccc aag gat
agg 336 Glu Ala Leu Leu Glu Lys Lys Ala Tyr Leu Glu Trp Pro Lys Asp
Arg 100 105 110 cgt aaa tgt ggg ctt ttc tgg gca aac ctt cga gct gct
gtt aat gtt 384 Arg Lys Cys Gly Leu Phe Trp Ala Asn Leu Arg Ala Ala
Val Asn Val 115 120 125 aat gta tta gcc acc aga gaa atg tat gaa ctg
cag aca ttc aca gag 432 Asn Val Leu Ala Thr Arg Glu Met Tyr Glu Leu
Gln Thr Phe Thr Glu 130 135 140 tta aat gaa gag tct cga ggt tct aca
atc tct ctg atg aga aca gac 480 Leu Asn Glu Glu Ser Arg Gly Ser Thr
Ile Ser Leu Met Arg Thr Asp 145 150 155 160 tgt cta taaaatccca
cagtccttgg gaagttgggg accacataca ctgttgggat 536 Cys Leu gtacattgat
acaaccttta tgatggcaat ttgacaatat ttattaaaat aaaaaatggt 596
tattcccttc aaaaaaaaaa aaaaaaaaaa aaa 629 <210> SEQ ID NO 20
<211> LENGTH: 162 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (48)..(48) <223> OTHER INFORMATION: Ser
<400> SEQUENCE: 20 Asn Glu Leu Ile Pro Asn Leu Glu Lys Glu
Asp Gly Ser Ile Leu Ile 1 5 10 15 Cys Leu Tyr Glu Ser Tyr Phe Asp
Pro Gly Lys Ser Ile Ser Glu Asn 20 25 30 Ile Val Ser Phe Ile Glu
Lys Ser Tyr Lys Ser Ile Phe Val Leu Xaa 35 40 45 Pro Asn Phe Val
Gln Asn Glu Trp Cys His Tyr Glu Phe Tyr Phe Ala 50 55 60 His His
Asn Leu Phe His Glu Asn Ser Asp His Ile Ile Leu Ile Leu 65 70 75 80
Leu Glu Pro Ile Pro Phe Tyr Cys Ile Pro Thr Arg Tyr His Lys Leu 85
90 95 Glu Ala Leu Leu Glu Lys Lys Ala Tyr Leu Glu Trp Pro Lys Asp
Arg 100 105 110 Arg Lys Cys Gly Leu Phe Trp Ala Asn Leu Arg Ala Ala
Val Asn Val 115 120 125 Asn Val Leu Ala Thr Arg Glu Met Tyr Glu Leu
Gln Thr Phe Thr Glu 130 135 140 Leu Asn Glu Glu Ser Arg Gly Ser Thr
Ile Ser Leu Met Arg Thr Asp 145 150 155 160 Cys Leu <210> SEQ
ID NO 21 <211> LENGTH: 427 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (1)..(426) <400> SEQUENCE: 21 aag
aac tcc aaa gaa aac ctc cag ttt cat gct ttt att tca tat agt 48 Lys
Asn Ser Lys Glu Asn Leu Gln Phe His Ala Phe Ile Ser Tyr Ser 1 5 10
15 gaa cat gat tct gcc tgg gtg aaa agt gaa ttg gta cct tac cta gaa
96 Glu His Asp Ser Ala Trp Val Lys Ser Glu Leu Val Pro Tyr Leu Glu
20 25 30 aaa gaa gat ata cag att tgt ctt cat gag aga aac ttt gtc
cct ggc 144 Lys Glu Asp Ile Gln Ile Cys Leu His Glu Arg Asn Phe Val
Pro Gly 35 40 45 aag agc att gtg gaa aat atc atc aac tgc att gag
aag agt tac aag 192 Lys Ser Ile Val Glu Asn Ile Ile Asn Cys Ile Glu
Lys Ser Tyr Lys 50 55 60 tcc atc ttt gtt ttg tct ccc aac ttt gtc
cag agt gag tgg tgc cat 240 Ser Ile Phe Val Leu Ser Pro Asn Phe Val
Gln Ser Glu Trp Cys His 65 70 75 80 tac gaa ctc tat ttt gcc cat cac
aat ctc ttt cat gaa gga tct aat 288 Tyr Glu Leu Tyr Phe Ala His His
Asn Leu Phe His Glu Gly Ser Asn 85 90 95 aac tta atc ctc atc tta
ctg gaa ccc att cca cag aac agc att ccc 336 Asn Leu Ile Leu Ile Leu
Leu Glu Pro Ile Pro Gln Asn Ser Ile Pro 100 105 110 aac aag tac cac
aag ctg aag gct ctc atg acg cag cgg act tat ttg 384 Asn Lys Tyr His
Lys Leu Lys Ala Leu Met Thr Gln Arg Thr Tyr Leu 115 120 125 cag tgg
ccc aag gag aaa agc aaa cgt ggg ctc ttt tgg gct a 427 Gln Trp Pro
Lys Glu Lys Ser Lys Arg Gly Leu Phe Trp Ala 130 135 140 <210>
SEQ ID NO 22 <211> LENGTH: 142 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 22 Lys Asn
Ser Lys Glu Asn Leu Gln Phe His Ala Phe Ile Ser Tyr Ser 1 5 10 15
Glu His Asp Ser Ala Trp Val Lys Ser Glu Leu Val Pro Tyr Leu Glu 20
25 30 Lys Glu Asp Ile Gln Ile Cys Leu His Glu Arg Asn Phe Val Pro
Gly 35 40 45 Lys Ser Ile Val Glu Asn Ile Ile Asn Cys Ile Glu Lys
Ser Tyr Lys 50 55 60 Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln
Ser Glu Trp Cys His 65 70 75 80 Tyr Glu Leu Tyr Phe Ala His His Asn
Leu Phe His Glu Gly Ser Asn 85 90 95 Asn Leu Ile Leu Ile Leu Leu
Glu Pro Ile Pro Gln Asn Ser Ile Pro 100 105 110 Asn Lys Tyr His Lys
Leu Lys Ala Leu Met Thr Gln Arg Thr Tyr Leu 115 120 125 Gln Trp Pro
Lys Glu Lys Ser Lys Arg Gly Leu Phe Trp Ala 130 135 140 <210>
SEQ ID NO 23 <211> LENGTH: 662 <212> TYPE: DNA
<213> ORGANISM: Homo sapiens <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(627) <220> FEATURE:
<221> NAME/KEY: modified_base <222> LOCATION:
(103)..(105) <223> OTHER INFORMATION: Position 103 may be a
or g, and this codon may encode Gly or Arg <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(313)..(315) <223> OTHER INFORMATION: Position 313 may be g
or t, and this codon may encode Val or Phe <220> FEATURE:
<221> NAME/KEY: modified_base <222> LOCATION:
(316)..(318) <223> OTHER INFORMATION: Position 316 may be a,
c, t, or g, and this codon may encode Ile, Val, Leu, or Phe
<220> FEATURE: <221> NAME/KEY: modified_base
<222> LOCATION: (379)..(381) <223> OTHER INFORMATION:
Position 380 may be a, c, t, or g, and this codon may encode Lys,
Arg, Thr, or Met <220> FEATURE: <221> NAME/KEY:
modified_base <222> LOCATION: (406)..(408) <223> OTHER
INFORMATION: Positions 407 and 408 may be a, c, t, or g, and this
codon may encode Gln, His, Arg, Pro, or Leu <400> SEQUENCE:
23 gct tcc acc tgt gcc tgg cct ggc ttc cct ggc ggg ggc ggc aaa gtg
48 Ala Ser Thr Cys Ala Trp Pro Gly Phe Pro Gly Gly Gly Gly Lys Val
1 5 10 15 ggc gar atg agg atg ccc tgc cct acg atg cct tcg tgg tct
tcg aca 96 Gly Glu Met Arg Met Pro Cys Pro Thr Met Pro Ser Trp Ser
Ser Thr 20 25 30 aaa cgc rga gcg cag tgg cag act ggg tgt aca acg
agc ttc ggg ggc 144 Lys Arg Xaa Ala Gln Trp Gln Thr Gly Cys Thr Thr
Ser Phe Gly Gly 35 40 45 agc tgg agg agt gcc gtg ggc gct ggg cac
tcc gcc tgt gcc tgg agg 192 Ser Trp Arg Ser Ala Val Gly Ala Gly His
Ser Ala Cys Ala Trp Arg 50 55 60 aac gcg act ggc tgc ctg gca aaa
ccc tct ttg aga acc tgt ggg cct 240 Asn Ala Thr Gly Cys Leu Ala Lys
Pro Ser Leu Arg Thr Cys Gly Pro 65 70 75 80 cgg tct atg gca gcc gca
aga cgc tgt ttg tgc tgg ccc aca cgg acc 288 Arg Ser Met Ala Ala Ala
Arg Arg Cys Leu Cys Trp Pro Thr Arg Thr 85 90 95 ggg tca gtg gtc
tct tgc gcg cca ktt ntc ctg ctg gcc cag cag cgc 336 Gly Ser Val Val
Ser Cys Ala Pro Xaa Xaa Leu Leu Ala Gln Gln Arg 100 105 110 ctg ctg
gar gac cgc aag gac gtc gtg gtg ctg gtg atc cta ang cct 384 Leu Leu
Glu Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Xaa Pro 115 120 125
gac ggc caa gcc tcc cga cta cnn gat gcg ctg acc agc gcc tct gcc 432
Asp Gly Gln Ala Ser Arg Leu Xaa Asp Ala Leu Thr Ser Ala Ser Ala 130
135 140 gcc aga gtg tcc tcc tct ggc ccc acc agc cca gtg gtc gcg cag
ctt 480 Ala Arg Val Ser Ser Ser Gly Pro Thr Ser Pro Val Val Ala Gln
Leu 145 150 155 160 ctg agg cca gca tgc atg gcc ctg acc agg gac aac
cac cac ttc tat 528 Leu Arg Pro Ala Cys Met Ala Leu Thr Arg Asp Asn
His His Phe Tyr 165 170 175 aac cgg aac ttc tgc cag gga acc cac ggc
cga ata gcc gtg agc cgg 576 Asn Arg Asn Phe Cys Gln Gly Thr His Gly
Arg Ile Ala Val Ser Arg 180 185 190 aat cct gca cgg tgc cac ctc cac
aca cac cta aca tat gcc tgc ctg 624 Asn Pro Ala Arg Cys His Leu His
Thr His Leu Thr Tyr Ala Cys Leu 195 200 205 atc tgaccaacac
atgctcgcca ccctcaccac acacc 662 Ile <210> SEQ ID NO 24
<211> LENGTH: 209 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (35)..(35) <223> OTHER INFORMATION: Gly
or Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (105)..(105) <223> OTHER INFORMATION:
Val or Phe <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (106)..(106) <223> OTHER INFORMATION:
Ile, Val, Leu, or Phe <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (127)..(127) <223> OTHER
INFORMATION: Lys, Arg, Thr, or Met <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (136)..(136) <223>
OTHER INFORMATION: Gln, His, Arg, Pro, or Leu <400> SEQUENCE:
24 Ala Ser Thr Cys Ala Trp Pro Gly Phe Pro Gly Gly Gly Gly Lys Val
1 5 10 15 Gly Glu Met Arg Met Pro Cys Pro Thr Met Pro Ser Trp Ser
Ser Thr 20 25 30 Lys Arg Xaa Ala Gln Trp Gln Thr Gly Cys Thr Thr
Ser Phe Gly Gly 35 40 45 Ser Trp Arg Ser Ala Val Gly Ala Gly His
Ser Ala Cys Ala Trp Arg 50 55 60 Asn Ala Thr Gly Cys Leu Ala Lys
Pro Ser Leu Arg Thr Cys Gly Pro 65 70 75 80 Arg Ser Met Ala Ala Ala
Arg Arg Cys Leu Cys Trp Pro Thr Arg Thr 85 90 95 Gly Ser Val Val
Ser Cys Ala Pro Xaa Xaa Leu Leu Ala Gln Gln Arg 100 105 110 Leu Leu
Glu Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Xaa Pro 115 120 125
Asp Gly Gln Ala Ser Arg Leu Xaa Asp Ala Leu Thr Ser Ala Ser Ala 130
135 140 Ala Arg Val Ser Ser Ser Gly Pro Thr Ser Pro Val Val Ala Gln
Leu 145 150 155 160 Leu Arg Pro Ala Cys Met Ala Leu Thr Arg Asp Asn
His His Phe Tyr 165 170 175 Asn Arg Asn Phe Cys Gln Gly Thr His Gly
Arg Ile Ala Val Ser Arg 180 185 190 Asn Pro Ala Arg Cys His Leu His
Thr His Leu Thr Tyr Ala Cys Leu 195 200 205 Ile <210> SEQ ID
NO 25 <211> LENGTH: 4865 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (107)..(2617) <220> FEATURE:
<221> NAME/KEY: mat_peptide <222> LOCATION:
(173)..(2617) <400> SEQUENCE: 25 aaaatactcc cttgcctcaa
aaactgctcg gtcaaacggt gatagcaaac cacgcattca 60 cagggccact
gctgctcaca aaaccagtga ggatgatgcc aggatg atg tct gcc 115 Met Ser Ala
-20 tcg cgc ctg gct ggg act ctg atc cca gcc atg gcc ttc ctc tcc tgc
163 Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala Phe Leu Ser Cys
-15 -10 -5 gtg aga cca gaa agc tgg gag ccc tgc gtg gag gtt cct aat
att act 211 Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val Pro Asn
Ile Thr -1 1 5 10 15 tat caa tgc atg gag ctg aat ttc tac aaa atc
ccc gac aac ctc ccc 259 Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile
Pro Asp Asn Leu Pro 20 25 30 ttc tca acc aag aac ctg gac ctg agc
ttt aat ccc ctg agg cat tta 307 Phe Ser Thr Lys Asn Leu Asp Leu Ser
Phe Asn Pro Leu Arg His Leu 35 40 45 ggc agc tat agc ttc ttc agt
ttc cca gaa ctg cag gtg ctg gat tta 355 Gly Ser Tyr Ser Phe Phe Ser
Phe Pro Glu Leu Gln Val Leu Asp Leu 50 55 60 tcc agg tgt gaa atc
cag aca att gaa gat ggg gca tat cag agc cta 403 Ser Arg Cys Glu Ile
Gln Thr Ile Glu Asp Gly Ala Tyr Gln Ser Leu 65 70 75 agc cac ctc
tct acc tta ata ttg aca gga aac ccc atc cag agt tta 451 Ser His Leu
Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile Gln Ser Leu 80 85 90 95 gcc
ctg gga gcc ttt tct gga cta tca agt tta cag aag ctg gtg gct 499 Ala
Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu Gln Lys Leu Val Ala 100 105
110 gtg gag aca aat cta gca tct cta gag aac ttc ccc att gga cat ctc
547 Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile Gly His Leu
115 120 125 aaa act ttg aaa gaa ctt aat gtg gct cac aat ctt atc caa
tct ttc 595 Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn Leu Ile Gln
Ser Phe 130 135 140 aaa tta cct gag tat ttt tct aat ctg acc aat cta
gag cac ttg gac 643 Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn Leu
Glu His Leu Asp 145 150 155 ctt tcc agc aac aag att caa agt att tat
tgc aca gac ttg cgg gtt 691 Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr
Cys Thr Asp Leu Arg Val 160 165 170 175 cta cat caa atg ccc cta ctc
aat ctc tct tta gac ctg tcc ctg aac 739 Leu His Gln Met Pro Leu Leu
Asn Leu Ser Leu Asp Leu Ser Leu Asn 180 185 190 cct atg aac ttt atc
caa cca ggt gca ttt aaa gaa att agg ctt cat 787 Pro Met Asn Phe Ile
Gln Pro Gly Ala Phe Lys Glu Ile Arg Leu His 195 200 205 aag ctg act
tta aga aat aat ttt gat agt tta aat gta atg aaa act 835 Lys Leu Thr
Leu Arg Asn Asn Phe Asp Ser Leu Asn Val Met Lys Thr 210 215 220 tgt
att caa ggt ctg gct ggt tta gaa gtc cat cgt ttg gtt ctg gga 883 Cys
Ile Gln Gly Leu Ala Gly Leu Glu Val His Arg Leu Val Leu Gly 225 230
235 gaa ttt aga aat gaa gga aac ttg gaa aag ttt gac aaa tct gct cta
931 Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys Ser Ala Leu
240 245 250 255 gag ggc ctg tgc aat ttg acc att gaa gaa ttc cga tta
gca tac tta 979 Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe Arg Leu
Ala Tyr Leu 260 265 270 gac tac tac ctc gat gat att att gac tta ttt
aat tgt ttg aca aat 1027 Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu
Phe Asn Cys Leu Thr Asn 275 280 285 gtt tct tca ttt tcc ctg gtg agt
gtg act att gaa agg gta aaa gac 1075 Val Ser Ser Phe Ser Leu Val
Ser Val Thr Ile Glu Arg Val Lys Asp 290 295 300 ttt tct tat aat ttc
gga tgg caa cat tta gaa tta gtt aac tgt aaa 1123 Phe Ser Tyr Asn
Phe Gly Trp Gln His Leu Glu Leu Val Asn Cys Lys 305 310 315 ttt gga
cag ttt ccc aca ttg aaa ctc aaa tct ctc aaa agg ctt act 1171 Phe
Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser Leu Lys Arg Leu Thr 320 325
330 335 ttc act tcc aac aaa ggt ggg aat gct ttt tca gaa gtt gat cta
cca 1219 Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser Glu Val Asp
Leu Pro 340 345 350 agc ctt gag ttt cta gat ctc agt aga aat ggc ttg
agt ttc aaa ggt 1267 Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly
Leu Ser Phe Lys Gly 355 360 365 tgc tgt tct caa agt gat ttt ggg aca
acc agc cta aag tat tta gat 1315 Cys Cys Ser Gln Ser Asp Phe Gly
Thr Thr Ser Leu Lys Tyr Leu Asp 370 375 380 ctg agc ttc aat ggt gtt
att acc atg agt tca aac ttc ttg ggc tta 1363 Leu Ser Phe Asn Gly
Val Ile Thr Met Ser Ser Asn Phe Leu Gly Leu 385 390 395 gaa caa cta
gaa cat ctg gat ttc cag cat tcc aat ttg aaa caa atg 1411 Glu Gln
Leu Glu His Leu Asp Phe Gln His Ser Asn Leu Lys Gln Met 400 405 410
415 agt gag ttt tca gta ttc cta tca ctc aga aac ctc att tac ctt gac
1459 Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn Leu Ile Tyr Leu
Asp 420 425 430 att tct cat act cac acc aga gtt gct ttc aat ggc atc
ttc aat ggc 1507 Ile Ser His Thr His Thr Arg Val Ala Phe Asn Gly
Ile Phe Asn Gly 435 440 445 ttg tcc agt ctc gaa gtc ttg aaa atg gct
ggc aat tct ttc cag gaa 1555 Leu Ser Ser Leu Glu Val Leu Lys Met
Ala Gly Asn Ser Phe Gln Glu 450 455 460 aac ttc ctt cca gat atc ttc
aca gag ctg aga aac ttg acc ttc ctg 1603 Asn Phe Leu Pro Asp Ile
Phe Thr Glu Leu Arg Asn Leu Thr Phe Leu 465 470 475 gac ctc tct cag
tgt caa ctg gag cag ttg tct cca aca gca ttt aac 1651 Asp Leu Ser
Gln Cys Gln Leu Glu Gln Leu Ser Pro Thr Ala Phe Asn 480 485 490 495
tca ctc tcc agt ctt cag gta cta aat atg agc cac aac aac ttc ttt
1699 Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser His Asn Asn Phe
Phe 500 505 510 tca ttg gat acg ttt cct tat aag tgt ctg aac tcc ctc
cag gtt ctt 1747 Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn Ser
Leu Gln Val Leu 515 520 525 gat tac agt ctc aat cac ata atg act tcc
aaa aaa cag gaa cta cag 1795 Asp Tyr Ser Leu Asn His Ile Met Thr
Ser Lys Lys Gln Glu Leu Gln 530 535 540 cat ttt cca agt agt cta gct
ttc tta aat ctt act cag aat gac ttt 1843 His Phe Pro Ser Ser Leu
Ala Phe Leu Asn Leu Thr Gln Asn Asp Phe 545 550 555 gct tgt act tgt
gaa cac cag agt ttc ctg caa tgg atc aag gac cag 1891 Ala Cys Thr
Cys Glu His Gln Ser Phe Leu Gln Trp Ile Lys Asp Gln 560 565 570 575
agg cag ctc ttg gtg gaa gtt gaa cga atg gaa tgt gca aca cct tca
1939 Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu Cys Ala Thr Pro
Ser 580 585 590 gat aag cag ggc atg cct gtg ctg agt ttg aat atc acc
tgt cag atg 1987 Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn Ile
Thr Cys Gln Met 595 600 605 aat aag acc atc att ggt gtg tcg gtc ctc
agt gtg ctt gta gta tct 2035 Asn Lys Thr Ile Ile Gly Val Ser Val
Leu Ser Val Leu Val Val Ser 610 615 620 gtt gta gca gtt ctg gtc tat
aag ttc tat ttt cac ctg atg ctt ctt 2083 Val Val Ala Val Leu Val
Tyr Lys Phe Tyr Phe His Leu Met Leu Leu 625 630 635 gct ggc tgc ata
aag tat ggt aga ggt gaa aac atc tat gat gcc ttt 2131 Ala Gly Cys
Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr Asp Ala Phe 640 645 650 655
gtt atc tac tca agc cag gat gag gac tgg gta agg aat gag cta gta
2179 Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu Leu
Val 660 665 670 aag aat tta gaa gaa ggg gtg cct cca ttt cag ctc tgc
ctt cac tac 2227 Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln Leu
Cys Leu His Tyr 675 680 685 aga gac ttt att ccc ggt gtg gcc att gct
gcc aac atc atc cat gaa 2275 Arg Asp Phe Ile Pro Gly Val Ala Ile
Ala Ala Asn Ile Ile His Glu 690 695 700 ggt ttc cat aaa agc cga aag
gtg att gtt gtg gtg tcc cag cac ttc 2323 Gly Phe His Lys Ser Arg
Lys Val Ile Val Val Val Ser Gln His Phe 705 710 715 atc cag agc cgc
tgg tgt atc ttt gaa tat gag att gct cag acc tgg 2371 Ile Gln Ser
Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala Gln Thr Trp 720 725 730 735
cag ttt ctg agc agt cgt gct ggt atc atc ttc att gtc ctg cag aag
2419 Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val Leu Gln
Lys 740 745 750 gtg gag aag acc ctg ctc agg cag cag gtg gag ctg tac
cgc ctt ctc 2467 Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu Leu
Tyr Arg Leu Leu 755 760 765 agc agg aac act tac ctg gag tgg gag gac
agt gtc ctg ggg cgg cac 2515 Ser Arg Asn Thr Tyr Leu Glu Trp Glu
Asp Ser Val Leu Gly Arg His 770 775 780 atc ttc tgg aga cga ctc aga
aaa gcc ctg ctg gat ggt aaa tca tgg 2563 Ile Phe Trp Arg Arg Leu
Arg Lys Ala Leu Leu Asp Gly Lys Ser Trp 785 790 795 aat cca gaa gga
aca gtg ggt aca gga tgc aat tgg cag gaa gca aca 2611 Asn Pro Glu
Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu Ala Thr 800 805 810 815
tct atc tgaagaggaa aaataaaaac ctcctgaggc atttcttgcc cagctgggtc 2667
Ser Ile caacacttgt tcagttaata agtattaaat gctgccacat gtcaggcctt
atgctaaggg 2727 tgagtaattc catggtgcac tagatatgca gggctgctaa
tctcaaggag cttccagtgc 2787 agagggaata aatgctagac taaaatacag
agtcttccag gtgggcattt caaccaactc 2847 agtcaaggaa cccatgacaa
agaaagtcat ttcaactctt acctcatcaa gttgaataaa 2907 gacagagaaa
acagaaagag acattgttct tttcctgagt cttttgaatg gaaattgtat 2967
tatgttatag ccatcataaa accattttgg tagttttgac tgaactgggt gttcactttt
3027 tcctttttga ttgaatacaa tttaaattct acttgatgac tgcagtcgtc
aaggggctcc 3087 tgatgcaaga tgccccttcc attttaagtc tgtctcctta
cagaggttaa agtctaatgg 3147 ctaattccta aggaaacctg attaacacat
gctcacaacc atcctggtca ttctcgaaca 3207 tgttctattt tttaactaat
cacccctgat atatttttat ttttatatat ccagttttca 3267 tttttttacg
tcttgcctat aagctaatat cataaataag gttgtttaag acgtgcttca 3327
aatatccata ttaaccacta tttttcaagg aagtatggaa aagtacactc tgtcactttg
3387 tcactcgatg tcattccaaa gttattgcct actaagtaat gactgtcatg
aaagcagcat 3447 tgaaataatt tgtttaaagg gggcactctt ttaaacggga
agaaaatttc cgcttcctgg 3507 tcttatcatg gacaatttgg gctagaggca
ggaaggaagt gggatgacct caggaagtca 3567 ccttttcttg attccagaaa
catatgggct gataaacccg gggtgacctc atgaaatgag 3627 ttgcagcaga
agtttatttt tttcagaaca agtgatgttt gatggacctc tgaatctctt 3687
tagggagaca cagatggctg ggatccctcc cctgtaccct tctcactgcc aggagaacta
3747 cgtgtgaagg tattcaaggc agggagtata cattgctgtt tcctgttggg
caatgctcct 3807 tgaccacatt ttgggaagag tggatgttat cattgagaaa
acaatgtgtc tggaattaat 3867 ggggttctta taaagaaggt tcccagaaaa
gaatgttcat tccagcttct tcaggaaaca 3927 ggaacattca aggaaaagga
caatcaggat gtcatcaggg aaatgaaaat aaaaaccaca 3987 atgagatatc
accttatacc aggtagatgg ctactataaa aaaatgaagt gtcatcaagg 4047
atatagagaa attggaaccc ttcttcactg ctggagggaa tggaaaatgg tgtagccgtt
4107 atgaaaaaca gtacggaggt ttctcaaaaa ttaaaaatag aactgctata
tgatccagca 4167 atctcacttc tgtatatata cccaaaataa ttgaaatcag
aatttcaaga aaatatttac 4227 actcccatgt tcattgtggc actcttcaca
atcactgttt ccaaagttat ggaaacaacc 4287 caaatttcca ttggaaaata
aatggacaaa ggaaatgtgc atataacgta caatggggat 4347 attattcagc
ctaaaaaaag gggggatcct gttatttatg acaacatgaa taaacccgga 4407
ggccattatg ctatgtaaaa tgagcaagta acagaaagac aaatactgcc tgatttcatt
4467 tatatgaggt tctaaaatag tcaaactcat agaagcagag aatagaacag
tggttcctag 4527 ggaaaaggag gaagggagaa atgaggaaat agggagttgt
ctaattggta taaaattata 4587 gtatgcaaga tgaattagct ctaaagatca
gctgtatagc agagttcgta taatgaacaa 4647 tactgtatta tgcacttaac
attttgttaa gagggtacct ctcatgttaa gtgttcttac 4707 catatacata
tacacaagga agcttttgga ggtgatggat atatttatta ccttgattgt 4767
ggtgatggtt tgacaggtat gtgactatgt ctaaactcat caaattgtat acattaaata
4827 tatgcagttt tataatatca aaaaaaaaaa aaaaaaaa 4865 <210> SEQ
ID NO 26 <211> LENGTH: 837 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 26 Met Ser Ala Ser Arg
Leu Ala Gly Thr Leu Ile Pro Ala Met Ala Phe -20 -15 -10 Leu Ser Cys
Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val Pro -5 -1 1 5 Asn
Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile Pro Asp 10 15
20 25 Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn Pro
Leu 30 35 40 Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu
Leu Gln Val 45 50 55 Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile
Glu Asp Gly Ala Tyr 60 65 70 Gln Ser Leu Ser His Leu Ser Thr Leu
Ile Leu Thr Gly Asn Pro Ile 75 80 85 90 Gln Ser Leu Ala Leu Gly Ala
Phe Ser Gly Leu Ser Ser Leu Gln Lys 95 100 105 Leu Val Ala Val Glu
Thr Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile 110 115 120 Gly His Leu
Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn Leu Ile 125 130 135 Gln
Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn Leu Glu 140 145
150 His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys Thr Asp
155 160 165 170 Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser
Leu Asp Leu 175 180 185 Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly
Ala Phe Lys Glu Ile 190 195 200 Arg Leu His Lys Leu Thr Leu Arg Asn
Asn Phe Asp Ser Leu Asn Val 205 210 215 Met Lys Thr Cys Ile Gln Gly
Leu Ala Gly Leu Glu Val His Arg Leu 220 225 230 235 Val Leu Gly Glu
Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys 240 245 250 Ser Ala
Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe Arg Leu 255 260 265
Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe Asn Cys 270
275 280 Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile Glu
Arg 285 290 295 Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu
Glu Leu Val 300 305 310 315 Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu
Lys Leu Lys Ser Leu Lys 320 325 330 Arg Leu Thr Phe Thr Ser Asn Lys
Gly Gly Asn Ala Phe Ser Glu Val 335 340 345 Asp Leu Pro Ser Leu Glu
Phe Leu Asp Leu Ser Arg Asn Gly Leu Ser 350 355 360 Phe Lys Gly Cys
Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser Leu Lys 365 370 375 Tyr Leu
Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser Asn Phe 380 385 390
395 Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser Asn Leu
400 405 410 Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn
Leu Ile 415 420 425 Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala
Phe Asn Gly Ile 430 435 440 Phe Asn Gly Leu Ser Ser Leu Glu Val Leu
Lys Met Ala Gly Asn Ser 445 450 455 Phe Gln Glu Asn Phe Leu Pro Asp
Ile Phe Thr Glu Leu Arg Asn Leu 460 465 470 475 Thr Phe Leu Asp Leu
Ser Gln Cys Gln Leu Glu Gln Leu Ser Pro Thr 480 485 490 Ala Phe Asn
Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser His Asn 495 500 505 Asn
Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn Ser Leu 510 515
520 Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys Lys Gln
525 530 535 Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu
Thr Gln 540 545 550 555 Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser
Phe Leu Gln Trp Ile 560 565 570 Lys Asp Gln Arg Gln Leu Leu Val Glu
Val Glu Arg Met Glu Cys Ala 575 580 585 Thr Pro Ser Asp Lys Gln Gly
Met Pro Val Leu Ser Leu Asn Ile Thr 590 595 600 Cys Gln Met Asn Lys
Thr Ile Ile Gly Val Ser Val Leu Ser Val Leu 605 610 615 Val Val Ser
Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu 620 625 630 635
Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr 640
645 650 Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg
Asn 655 660 665 Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe
Gln Leu Cys 670 675 680 Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala
Ile Ala Ala Asn Ile 685 690 695 Ile His Glu Gly Phe His Lys Ser Arg
Lys Val Ile Val Val Val Ser 700 705 710 715 Gln His Phe Ile Gln Ser
Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala 720 725 730 Gln Thr Trp Gln
Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val 735 740 745 Leu Gln
Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr 750 755 760
Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu 765
770 775 Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp
Gly 780 785 790 795 Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly
Cys Asn Trp Gln 800 805 810 Glu Ala Thr Ser Ile 815 <210> SEQ
ID NO 27 <211> LENGTH: 300 <212> TYPE: DNA <213>
ORGANISM: Mus musculus <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (1)..(300) <400> SEQUENCE: 27 tcc
tat tct atg gaa aaa gat gct ttc cta ttt atg aga aat ttg aag 48 Ser
Tyr Ser Met Glu Lys Asp Ala Phe Leu Phe Met Arg Asn Leu Lys 1 5 10
15 gtt ctc tca cta aaa gat aac aat gtc aca gct gtc ccc acc act ttg
96 Val Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Thr Leu
20 25 30 cca cct aat tta cta gag ctc tat ctt tat aac aat atc att
aag aaa 144 Pro Pro Asn Leu Leu Glu Leu Tyr Leu Tyr Asn Asn Ile Ile
Lys Lys 35 40 45 atc caa gaa aat gat ttc aat aac ctc aat gag ttg
caa gtc ctt gac 192 Ile Gln Glu Asn Asp Phe Asn Asn Leu Asn Glu Leu
Gln Val Leu Asp 50 55 60 cta cgt gga aat tgc cct cga tgt cat aat
gtc cca tat ccg tgt aca 240 Leu Arg Gly Asn Cys Pro Arg Cys His Asn
Val Pro Tyr Pro Cys Thr 65 70 75 80 ccg tgt gaa aat aat tcc ccc tta
cag atc cat gac aat gct ttc aat 288 Pro Cys Glu Asn Asn Ser Pro Leu
Gln Ile His Asp Asn Ala Phe Asn 85 90 95 tca tcg aca gac 300 Ser
Ser Thr Asp 100 <210> SEQ ID NO 28 <211> LENGTH: 100
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 28 Ser Tyr Ser Met Glu Lys Asp Ala Phe Leu
Phe Met Arg Asn Leu Lys 1 5 10 15 Val Leu Ser Leu Lys Asp Asn Asn
Val Thr Ala Val Pro Thr Thr Leu 20 25 30 Pro Pro Asn Leu Leu Glu
Leu Tyr Leu Tyr Asn Asn Ile Ile Lys Lys 35 40 45 Ile Gln Glu Asn
Asp Phe Asn Asn Leu Asn Glu Leu Gln Val Leu Asp 50 55 60 Leu Arg
Gly Asn Cys Pro Arg Cys His Asn Val Pro Tyr Pro Cys Thr 65 70 75 80
Pro Cys Glu Asn Asn Ser Pro Leu Gln Ile His Asp Asn Ala Phe Asn 85
90 95 Ser Ser Thr Asp 100 <210> SEQ ID NO 29 <211>
LENGTH: 1756 <212> TYPE: DNA <213> ORGANISM: Mus
musculus <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(1182) <400> SEQUENCE: 29 tct cca gaa att ccc
tgg aat tcc ttg cct cct gag gtt ttt gag ggt 48 Ser Pro Glu Ile Pro
Trp Asn Ser Leu Pro Pro Glu Val Phe Glu Gly 1 5 10 15 atg ccg cca
aat cta aag aat ctc tcc ttg gcc aaa aat ggg ctc aaa 96 Met Pro Pro
Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys 20 25 30 tct
ttc ttt tgg gac aga ctc cag tta ctg aag cat ttg gaa att ttg 144 Ser
Phe Phe Trp Asp Arg Leu Gln Leu Leu Lys His Leu Glu Ile Leu 35 40
45 gac ctc agc cat aac cag ctg aca aaa gta cct gag aga ttg gcc aac
192 Asp Leu Ser His Asn Gln Leu Thr Lys Val Pro Glu Arg Leu Ala Asn
50 55 60 tgt tcc aaa agt ctc aca aca ctg att ctt aag cat aat caa
atc agg 240 Cys Ser Lys Ser Leu Thr Thr Leu Ile Leu Lys His Asn Gln
Ile Arg 65 70 75 80 caa ttg aca aaa tat ttt cta gaa gat gct ttg caa
ttg cgc tat cta 288 Gln Leu Thr Lys Tyr Phe Leu Glu Asp Ala Leu Gln
Leu Arg Tyr Leu 85 90 95 gac atc agt tca aat aaa atc cag gtc att
cag aag act agc ttc cca 336 Asp Ile Ser Ser Asn Lys Ile Gln Val Ile
Gln Lys Thr Ser Phe Pro 100 105 110 gaa aat gtc ctc aac aat ctg gag
atg ttg gtt tta cat cac aat cgc 384 Glu Asn Val Leu Asn Asn Leu Glu
Met Leu Val Leu His His Asn Arg 115 120 125 ttt ctt tgc aac tgt gat
gct gtg tgg ttt gtc tgg tgg gtt aac cat 432 Phe Leu Cys Asn Cys Asp
Ala Val Trp Phe Val Trp Trp Val Asn His 130 135 140 aca gat gtt act
att cca tac ctg gcc act gat gtg act tgt gta ggt 480 Thr Asp Val Thr
Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly 145 150 155 160 cca
gga gca cac aaa ggt caa agt gtc ata tcc ctt gat ctg tat acg 528 Pro
Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr 165 170
175 tgt gag tta gat ctc aca aac ctg att ctg ttc tca gtt tcc ata tca
576 Cys Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Val Ser Ile Ser
180 185 190 tca gtc ctc ttt ctt atg gta gtt atg aca aca agt cac ctc
ttt ttc 624 Ser Val Leu Phe Leu Met Val Val Met Thr Thr Ser His Leu
Phe Phe 195 200 205 tgg gat atg tgg tac att tat tat ttt tgg aaa gca
aag ata aag ggg 672 Trp Asp Met Trp Tyr Ile Tyr Tyr Phe Trp Lys Ala
Lys Ile Lys Gly 210 215 220 tat cca gca tct gca atc cca tgg agt cct
tgt tat gat gct ttt att 720 Tyr Pro Ala Ser Ala Ile Pro Trp Ser Pro
Cys Tyr Asp Ala Phe Ile 225 230 235 240 gtg tat gac act aaa aac tca
gct gtg aca gaa tgg gtt ttg cag gag 768 Val Tyr Asp Thr Lys Asn Ser
Ala Val Thr Glu Trp Val Leu Gln Glu 245 250 255 ctg gtg gca aaa ttg
gaa gat cca aga gaa aaa cac ttc aat ttg tgt 816 Leu Val Ala Lys Leu
Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys 260 265 270 cta gaa gaa
aga gac tgg cta cca gga cag cca gtt cta gaa aac ctt 864 Leu Glu Glu
Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu 275 280 285 tcc
cag agc ata cag ctc agc aaa aag aca gtg ttt gtg atg aca cag 912 Ser
Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Gln 290 295
300 aaa tat gct aag act gag agt ttt aag atg gca ttt tat ttg tct cat
960 Lys Tyr Ala Lys Thr Glu Ser Phe Lys Met Ala Phe Tyr Leu Ser His
305 310 315 320 cag agg ctc ctg gat gaa aaa gtg gat gtg att atc ttg
ata ttc ttg 1008 Gln Arg Leu Leu Asp Glu Lys Val Asp Val Ile Ile
Leu Ile Phe Leu 325 330 335 gaa aga cct ctt cag aag tct aag ttt ctt
cag ctc agg aag aga ctc 1056 Glu Arg Pro Leu Gln Lys Ser Lys Phe
Leu Gln Leu Arg Lys Arg Leu 340 345 350 tgc agg agc tct gtc ctt gag
tgg cct gca aat cca cag gct cac cca 1104 Cys Arg Ser Ser Val Leu
Glu Trp Pro Ala Asn Pro Gln Ala His Pro 355 360 365 tac ttc tgg cag
tgc ctg aaa aat gcc ctg acc aca gac aat cat gtg 1152 Tyr Phe Trp
Gln Cys Leu Lys Asn Ala Leu Thr Thr Asp Asn His Val 370 375 380 gct
tat agt caa atg ttc aag gaa aca gtc tagctctctg aagaatgtca 1202 Ala
Tyr Ser Gln Met Phe Lys Glu Thr Val 385 390 ccacctagga catgccttgg
tacctgaagt tttcataaag gtttccataa atgaaggtct 1262 gaatttttcc
taacagttgt catggctcag attggtggga aatcatcaat atatggctaa 1322
gaaattaaga aggggagact gatagaagat aatttctttc ttcatgtgcc atgctcagtt
1382 aaatatttcc cctagctcaa atctgaaaaa ctgtgcctag gagacaacac
aaggctttga 1442 tttatctgca tacaattgat aagagccaca catctgccct
gaagaagtac tagtagtttt 1502 agtagtaggg taaaaattac acaagctttc
tctctctctg atactgaact gtaccagagt 1562 tcaatgaaat aaaagcccag
agaacttctc agtaaatggt ttcattatca tgtagtatcc 1622 accatgcaat
atgccacaaa accgctactg gtacaggaca gctggtagct gcttcaaggc 1682
ctcttatcat tttcttgggg cccatggagg ggttctctgg gaaaaaggga aggttttttt
1742 tggccatcca tgaa 1756 <210> SEQ ID NO 30 <211>
LENGTH: 394 <212> TYPE: PRT <213> ORGANISM: Mus
musculus <400> SEQUENCE: 30 Ser Pro Glu Ile Pro Trp Asn Ser
Leu Pro Pro Glu Val Phe Glu Gly 1 5 10 15 Met Pro Pro Asn Leu Lys
Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys 20 25 30 Ser Phe Phe Trp
Asp Arg Leu Gln Leu Leu Lys His Leu Glu Ile Leu 35 40 45 Asp Leu
Ser His Asn Gln Leu Thr Lys Val Pro Glu Arg Leu Ala Asn 50 55 60
Cys Ser Lys Ser Leu Thr Thr Leu Ile Leu Lys His Asn Gln Ile Arg 65
70 75 80 Gln Leu Thr Lys Tyr Phe Leu Glu Asp Ala Leu Gln Leu Arg
Tyr Leu 85 90 95 Asp Ile Ser Ser Asn Lys Ile Gln Val Ile Gln Lys
Thr Ser Phe Pro 100 105 110 Glu Asn Val Leu Asn Asn Leu Glu Met Leu
Val Leu His His Asn Arg 115 120 125 Phe Leu Cys Asn Cys Asp Ala Val
Trp Phe Val Trp Trp Val Asn His 130 135 140 Thr Asp Val Thr Ile Pro
Tyr Leu Ala Thr Asp Val Thr Cys Val Gly 145 150 155 160 Pro Gly Ala
His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr 165 170 175 Cys
Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Val Ser Ile Ser 180 185
190 Ser Val Leu Phe Leu Met Val Val Met Thr Thr Ser His Leu Phe Phe
195 200 205 Trp Asp Met Trp Tyr Ile Tyr Tyr Phe Trp Lys Ala Lys Ile
Lys Gly 210 215 220 Tyr Pro Ala Ser Ala Ile Pro Trp Ser Pro Cys Tyr
Asp Ala Phe Ile 225 230 235 240 Val Tyr Asp Thr Lys Asn Ser Ala Val
Thr Glu Trp Val Leu Gln Glu 245 250 255 Leu Val Ala Lys Leu Glu Asp
Pro Arg Glu Lys His Phe Asn Leu Cys 260 265 270 Leu Glu Glu Arg Asp
Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu 275 280 285 Ser Gln Ser
Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Gln 290 295 300 Lys
Tyr Ala Lys Thr Glu Ser Phe Lys Met Ala Phe Tyr Leu Ser His 305 310
315 320 Gln Arg Leu Leu Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe
Leu 325 330 335 Glu Arg Pro Leu Gln Lys Ser Lys Phe Leu Gln Leu Arg
Lys Arg Leu 340 345 350 Cys Arg Ser Ser Val Leu Glu Trp Pro Ala Asn
Pro Gln Ala His Pro 355 360 365 Tyr Phe Trp Gln Cys Leu Lys Asn Ala
Leu Thr Thr Asp Asn His Val 370 375 380 Ala Tyr Ser Gln Met Phe Lys
Glu Thr Val 385 390 <210> SEQ ID NO 31 <211> LENGTH:
999 <212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (2)..(847) <400> SEQUENCE: 31 c tcc gat gcc aag att
cgg cac cag gca tat tca gag gtc atg atg gtt 49 Ser Asp Ala Lys Ile
Arg His Gln Ala Tyr Ser Glu Val Met Met Val 1 5 10 15 gga tgg tca
gat tca tac acc tgt gaa tac cct tta aac cta agg gga 97 Gly Trp Ser
Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg Gly 20 25 30 act
agg tta aaa gac gtt cat ctc cac gaa tta tct tgc aac aca gct 145 Thr
Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr Ala 35 40
45 ctg ttg att gtc acc att gtg gtt att atg cta gtt ctg ggg ttg gct
193 Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu Ala
50 55 60 gtg gcc ttc tgc tgt ctc cac ttt gat ctg ccc tgg tat ctc
agg atg 241 Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu
Arg Met 65 70 75 80 cta ggt caa tgc aca caa aca tgg cac agg gtt agg
aaa aca acc caa 289 Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg
Lys Thr Thr Gln 85 90 95 gaa caa ctc aag aga aat gtc cga ttc cac
gca ttt att tca tac agt 337 Glu Gln Leu Lys Arg Asn Val Arg Phe His
Ala Phe Ile Ser Tyr Ser 100 105 110 gaa cat gat tct ctg tgg gtg aag
aat gaa ttg atc ccc aat cta gag 385 Glu His Asp Ser Leu Trp Val Lys
Asn Glu Leu Ile Pro Asn Leu Glu 115 120 125 aag gaa gat ggt tct atc
ttg att tgc ctt tat gaa agc tac ttt gac 433 Lys Glu Asp Gly Ser Ile
Leu Ile Cys Leu Tyr Glu Ser Tyr Phe Asp 130 135 140 cct ggc aaa agc
att agt gaa aat att gta agc ttc att gag aaa agc 481 Pro Gly Lys Ser
Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys Ser 145 150 155 160 tat
aag tcc atc ttt gtt ttg tct ccc aac ttt gtc cag aat gag tgg 529 Tyr
Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu Trp 165 170
175 tgc cat tat gaa ttc tac ttt gcc cac cac aat ctc ttc cat gaa aat
577 Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu Asn
180 185 190 tct gat cac ata att ctt atc tta ctg gaa ccc att cca ttc
tat tgc 625 Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe
Tyr Cys 195 200 205 att ccc acc agg tat cat aaa ctg gaa gct ctc ctg
gaa aaa aaa gca 673 Ile Pro Thr Arg Tyr His Lys Leu Glu Ala Leu Leu
Glu Lys Lys Ala 210 215 220 tac ttg gaa tgg ccc aag gat agg cgt aaa
tgt ggg ctt ttc tgg gca 721 Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys
Cys Gly Leu Phe Trp Ala 225 230 235 240 aac ctt cga gct gct gtt aat
gtt aat gta tta gcc acc aga gaa atg 769 Asn Leu Arg Ala Ala Val Asn
Val Asn Val Leu Ala Thr Arg Glu Met 245 250 255 tat gaa ctg cag aca
ttc aca gag tta aat gaa gag tct cga ggt tct 817 Tyr Glu Leu Gln Thr
Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly Ser 260 265 270 aca atc tct
ctg atg aga aca gac tgt cta taaaatccca cagtccttgg 867 Thr Ile Ser
Leu Met Arg Thr Asp Cys Leu 275 280 gaagttgggg accacataca
ctgttgggat gtacattgat acaaccttta tgatggcaat 927 ttgacaatat
ttattaaaat aaaaaatggt tattcccttc aaaaaaaaaa aaaaaaaaaa 987
aaaaaaaaaa aa 999 <210> SEQ ID NO 32 <211> LENGTH: 282
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 32 Ser Asp Ala Lys Ile Arg His Gln Ala Tyr
Ser Glu Val Met Met Val 1 5 10 15 Gly Trp Ser Asp Ser Tyr Thr Cys
Glu Tyr Pro Leu Asn Leu Arg Gly 20 25 30 Thr Arg Leu Lys Asp Val
His Leu His Glu Leu Ser Cys Asn Thr Ala 35 40 45 Leu Leu Ile Val
Thr Ile Val Val Ile Met Leu Val Leu Gly Leu Ala 50 55 60 Val Ala
Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg Met 65 70 75 80
Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr Gln 85
90 95 Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr
Ser 100 105 110 Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro
Asn Leu Glu 115 120 125 Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr
Glu Ser Tyr Phe Asp 130 135 140 Pro Gly Lys Ser Ile Ser Glu Asn Ile
Val Ser Phe Ile Glu Lys Ser 145 150 155 160 Tyr Lys Ser Ile Phe Val
Leu Ser Pro Asn Phe Val Gln Asn Glu Trp 165 170 175 Cys His Tyr Glu
Phe Tyr Phe Ala His His Asn Leu Phe His Glu Asn 180 185 190 Ser Asp
His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr Cys 195 200 205
Ile Pro Thr Arg Tyr His Lys Leu Glu Ala Leu Leu Glu Lys Lys Ala 210
215 220 Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp
Ala 225 230 235 240 Asn Leu Arg Ala Ala Val Asn Val Asn Val Leu Ala
Thr Arg Glu Met 245 250 255 Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn
Glu Glu Ser Arg Gly Ser 260 265 270 Thr Ile Ser Leu Met Arg Thr Asp
Cys Leu 275 280 <210> SEQ ID NO 33 <211> LENGTH: 1173
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(1008) <400> SEQUENCE: 33 ctg cct gct ggc acc
cgg ctc cgg agg ctg gat gtc agc tgc aac agc 48 Leu Pro Ala Gly Thr
Arg Leu Arg Arg Leu Asp Val Ser Cys Asn Ser 1 5 10 15 atc agc ttc
gtg gcc ccc ggc ttc ttt tcc aag gcc aag gag ctg cga 96 Ile Ser Phe
Val Ala Pro Gly Phe Phe Ser Lys Ala Lys Glu Leu Arg 20 25 30 gag
ctc aac ctt agc gcc aac gcc ctc aag aca gtg gac cac tcc tgg 144 Glu
Leu Asn Leu Ser Ala Asn Ala Leu Lys Thr Val Asp His Ser Trp 35 40
45 ttt ggg ccc ctg gcg agt gcc ctg caa ata cta gat gta agc gcc aac
192 Phe Gly Pro Leu Ala Ser Ala Leu Gln Ile Leu Asp Val Ser Ala Asn
50 55 60 cct ctg cac tgc gcc tgt ggg gcg gcc ttt atg gac ttc ctg
ctg gag 240 Pro Leu His Cys Ala Cys Gly Ala Ala Phe Met Asp Phe Leu
Leu Glu 65 70 75 80 gtg cag gct gcc gtg ccc ggt ctg ccc agc cgg gtg
aag tgt ggc agt 288 Val Gln Ala Ala Val Pro Gly Leu Pro Ser Arg Val
Lys Cys Gly Ser 85 90 95 ccg ggc cag ctc cag ggc ctc agc atc ttt
gca cag gac ctg cgc ctc 336 Pro Gly Gln Leu Gln Gly Leu Ser Ile Phe
Ala Gln Asp Leu Arg Leu 100 105 110 tgc ctg gat gag gcc ctc tcc tgg
gac tgt ttc gcc ctc tcg ctg ctg 384 Cys Leu Asp Glu Ala Leu Ser Trp
Asp Cys Phe Ala Leu Ser Leu Leu 115 120 125 gct gtg gct ctg ggc ctg
ggt gtg ccc atg ctg cat cac ctc tgt ggc 432 Ala Val Ala Leu Gly Leu
Gly Val Pro Met Leu His His Leu Cys Gly 130 135 140 tgg gac ctc tgg
tac tgc ttc cac ctg tgc ctg gcc tgg ctt ccc tgg 480 Trp Asp Leu Trp
Tyr Cys Phe His Leu Cys Leu Ala Trp Leu Pro Trp 145 150 155 160 cgg
ggg cgg caa agt ggg cga gat gag gat gcc ctg ccc tac gat gcc 528 Arg
Gly Arg Gln Ser Gly Arg Asp Glu Asp Ala Leu Pro Tyr Asp Ala 165 170
175 ttc gtg gtc ttc gac aaa acg cag agc gca gtg gca gac tgg gtg tac
576 Phe Val Val Phe Asp Lys Thr Gln Ser Ala Val Ala Asp Trp Val Tyr
180 185 190 aac gag ctt cgg ggg cag ctg gag gag tgc cgt ggg cgc tgg
gca ctc 624 Asn Glu Leu Arg Gly Gln Leu Glu Glu Cys Arg Gly Arg Trp
Ala Leu 195 200 205 cgc ctg tgc ctg gag gaa cgc gac tgg ctg cct ggc
aaa acc ctc ttt 672 Arg Leu Cys Leu Glu Glu Arg Asp Trp Leu Pro Gly
Lys Thr Leu Phe 210 215 220 gag aac ctg tgg gcc tcg gtc tat ggc agc
cgc aag acg ctg ttt gtg 720 Glu Asn Leu Trp Ala Ser Val Tyr Gly Ser
Arg Lys Thr Leu Phe Val 225 230 235 240 ctg gcc cac acg gac cgg gtc
agt ggt ctc ttg cgc gcc agc ttc ctg 768 Leu Ala His Thr Asp Arg Val
Ser Gly Leu Leu Arg Ala Ser Phe Leu 245 250 255 ctg gcc cag cag cgc
ctg ctg gag gac cgc aag gac gtc gtg gtg ctg 816 Leu Ala Gln Gln Arg
Leu Leu Glu Asp Arg Lys Asp Val Val Val Leu 260 265 270 gtg atc ctg
agc cct gac ggc cgc cgc tcc cgc tac gag cgg ctg cgc 864 Val Ile Leu
Ser Pro Asp Gly Arg Arg Ser Arg Tyr Glu Arg Leu Arg 275 280 285 cag
cgc ctc tgc cgc cag agt gtc ctc ctc tgg ccc cac cag ccc agt 912 Gln
Arg Leu Cys Arg Gln Ser Val Leu Leu Trp Pro His Gln Pro Ser 290 295
300 ggt cag cgc agc ttc tgg gcc cag ctg ggc atg gcc ctg acc agg gac
960 Gly Gln Arg Ser Phe Trp Ala Gln Leu Gly Met Ala Leu Thr Arg Asp
305 310 315 320 aac cac cac ttc tat aac cgg aac ttc tgc cag gga ccc
acg gcc gaa 1008 Asn His His Phe Tyr Asn Arg Asn Phe Cys Gln Gly
Pro Thr Ala Glu 325 330 335 tagccgtgag ccggaatcct gcacggtgcc
acctccacac tcacctcacc tctgcctgcc 1068 tggtctgacc ctcccctgct
cgcctccctc accccacacc tgacacagag caggcactca 1128 ataaatgcta
ccgaaggcta aaaaaaaaaa aaaaaaaaaa aacca 1173 <210> SEQ ID NO
34 <211> LENGTH: 336 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 34 Leu Pro Ala Gly Thr
Arg Leu Arg Arg Leu Asp Val Ser Cys Asn Ser 1 5 10 15 Ile Ser Phe
Val Ala Pro Gly Phe Phe Ser Lys Ala Lys Glu Leu Arg 20 25 30 Glu
Leu Asn Leu Ser Ala Asn Ala Leu Lys Thr Val Asp His Ser Trp 35 40
45 Phe Gly Pro Leu Ala Ser Ala Leu Gln Ile Leu Asp Val Ser Ala Asn
50 55 60 Pro Leu His Cys Ala Cys Gly Ala Ala Phe Met Asp Phe Leu
Leu Glu 65 70 75 80 Val Gln Ala Ala Val Pro Gly Leu Pro Ser Arg Val
Lys Cys Gly Ser 85 90 95 Pro Gly Gln Leu Gln Gly Leu Ser Ile Phe
Ala Gln Asp Leu Arg Leu 100 105 110 Cys Leu Asp Glu Ala Leu Ser Trp
Asp Cys Phe Ala Leu Ser Leu Leu 115 120 125 Ala Val Ala Leu Gly Leu
Gly Val Pro Met Leu His His Leu Cys Gly 130 135 140 Trp Asp Leu Trp
Tyr Cys Phe His Leu Cys Leu Ala Trp Leu Pro Trp 145 150 155 160 Arg
Gly Arg Gln Ser Gly Arg Asp Glu Asp Ala Leu Pro Tyr Asp Ala 165 170
175 Phe Val Val Phe Asp Lys Thr Gln Ser Ala Val Ala Asp Trp Val Tyr
180 185 190 Asn Glu Leu Arg Gly Gln Leu Glu Glu Cys Arg Gly Arg Trp
Ala Leu 195 200 205 Arg Leu Cys Leu Glu Glu Arg Asp Trp Leu Pro Gly
Lys Thr Leu Phe 210 215 220 Glu Asn Leu Trp Ala Ser Val Tyr Gly Ser
Arg Lys Thr Leu Phe Val 225 230 235 240 Leu Ala His Thr Asp Arg Val
Ser Gly Leu Leu Arg Ala Ser Phe Leu 245 250 255 Leu Ala Gln Gln Arg
Leu Leu Glu Asp Arg Lys Asp Val Val Val Leu 260 265 270 Val Ile Leu
Ser Pro Asp Gly Arg Arg Ser Arg Tyr Glu Arg Leu Arg 275 280 285 Gln
Arg Leu Cys Arg Gln Ser Val Leu Leu Trp Pro His Gln Pro Ser 290 295
300 Gly Gln Arg Ser Phe Trp Ala Gln Leu Gly Met Ala Leu Thr Arg Asp
305 310 315 320 Asn His His Phe Tyr Asn Arg Asn Phe Cys Gln Gly Pro
Thr Ala Glu 325 330 335 <210> SEQ ID NO 35 <211>
LENGTH: 497 <212> TYPE: DNA <213> ORGANISM: Mus
musculus <400> SEQUENCE: 35 tggcccacac ggaccgcgtc agtggcctcc
tgcgcaccag cttcctgctg gctcagcagc 60 gcctgttgga agaccgcaag
gacgtggtgg tgttggtgat cctgcgtccg gatgccccac 120 cgtcccgcta
tgtgcgactg cgccagcgtc tctgccgcca gagtgtgctc ttctggcccc 180
agcgacccaa cgggcagggg ggcttctggg cccagctgag tacagccctg actagggaca
240 accgccactt ctataaccag aacttctgcc ggggacctac agcagaatag
ctcagagcaa 300 cagctggaaa cagctgcatc ttcatgtctg gttcccgagt
tgctctgcct gccttgctct 360 gtcttactac accgctattt ggcaagtgcg
caatatatgc taccaagcca ccaggcccac 420 ggagcaaagg ttggctgtaa
agggtagttt tcttcccatg catctttcag gagagtgaag 480 atagacacca aacccac
497 <210> SEQ ID NO 36 <211> LENGTH: 3099 <212>
TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(3096)
<220> FEATURE: <221> NAME/KEY: mat_peptide <222>
LOCATION: (52)..(3096) <220> FEATURE: <221> NAME/KEY:
modified_base <222> LOCATION: (2224..(2226) <223> OTHER
INFORMATION: Position 2226 may be a or c, and this codon encodes
Ile <400> SEQUENCE: 36 atg ctg acc tgc att ttc ctg cta ata
tct ggt tcc tgt gag tta tgc 48 Met Leu Thr Cys Ile Phe Leu Leu Ile
Ser Gly Ser Cys Glu Leu Cys -15 -10 -5 -1 1 gcc gaa gaa aat ttt tct
aga agc tat cct tgt gat gag aaa aag caa 96 Ala Glu Glu Asn Phe Ser
Arg Ser Tyr Pro Cys Asp Glu Lys Lys Gln 5 10 15 aat gac tca gtt att
gca gag tgc agc aat cgt cga cta cag gaa gtt 144 Asn Asp Ser Val Ile
Ala Glu Cys Ser Asn Arg Arg Leu Gln Glu Val 20 25 30 ccc caa acg
gtg ggc aaa tat gtg aca gaa cta gac ctg tct gat aat 192 Pro Gln Thr
Val Gly Lys Tyr Val Thr Glu Leu Asp Leu Ser Asp Asn 35 40 45 ttc
atc aca cac ata acg aat gaa tca ttt caa ggg ctg caa aat ctc 240 Phe
Ile Thr His Ile Thr Asn Glu Ser Phe Gln Gly Leu Gln Asn Leu 50 55
60 act aaa ata aat cta aac cac aac ccc aat gta cag cac cag aac gga
288 Thr Lys Ile Asn Leu Asn His Asn Pro Asn Val Gln His Gln Asn Gly
65 70 75 80 aat ccc ggt ata caa tca aat ggc ttg aat atc aca gac ggg
gca ttc 336 Asn Pro Gly Ile Gln Ser Asn Gly Leu Asn Ile Thr Asp Gly
Ala Phe 85 90 95 ctc aac cta aaa aac cta agg gag tta ctg ctt gaa
gac aac cag tta 384 Leu Asn Leu Lys Asn Leu Arg Glu Leu Leu Leu Glu
Asp Asn Gln Leu 100 105 110 ccc caa ata ccc tct ggt ttg cca gag tct
ttg aca gaa ctt agt cta 432 Pro Gln Ile Pro Ser Gly Leu Pro Glu Ser
Leu Thr Glu Leu Ser Leu 115 120 125 att caa aac aat ata tac aac ata
act aaa gag ggc att tca aga ctt 480 Ile Gln Asn Asn Ile Tyr Asn Ile
Thr Lys Glu Gly Ile Ser Arg Leu 130 135 140 ata aac ttg aaa aat ctc
tat ttg gcc tgg aac tgc tat ttt aac aaa 528 Ile Asn Leu Lys Asn Leu
Tyr Leu Ala Trp Asn Cys Tyr Phe Asn Lys 145 150 155 160 gtt tgc gag
aaa act aac ata gaa gat gga gta ttt gaa acg ctg aca 576 Val Cys Glu
Lys Thr Asn Ile Glu Asp Gly Val Phe Glu Thr Leu Thr 165 170 175 aat
ttg gag ttg cta tca cta tct ttc aat tct ctt tca cat gtg cca 624 Asn
Leu Glu Leu Leu Ser Leu Ser Phe Asn Ser Leu Ser His Val Pro 180 185
190 ccc aaa ctg cca agc tcc cta cgc aaa ctt ttt ctg agc aac acc cag
672 Pro Lys Leu Pro Ser Ser Leu Arg Lys Leu Phe Leu Ser Asn Thr Gln
195 200 205 atc aaa tac att agt gaa gaa gat ttc aag gga ttg ata aat
tta aca 720 Ile Lys Tyr Ile Ser Glu Glu Asp Phe Lys Gly Leu Ile Asn
Leu Thr 210 215 220 tta cta gat tta agc ggg aac tgt ccg agg tgc ttc
aat gcc cca ttt 768 Leu Leu Asp Leu Ser Gly Asn Cys Pro Arg Cys Phe
Asn Ala Pro Phe 225 230 235 240 cca tgc gtg cct tgt gat ggt ggt gct
tca att aat ata gat cgt ttt 816 Pro Cys Val Pro Cys Asp Gly Gly Ala
Ser Ile Asn Ile Asp Arg Phe 245 250 255 gct ttt caa aac ttg acc caa
ctt cga tac cta aac ctc tct agc act 864 Ala Phe Gln Asn Leu Thr Gln
Leu Arg Tyr Leu Asn Leu Ser Ser Thr 260 265 270 tcc ctc agg aag att
aat gct gcc tgg ttt aaa aat atg cct cat ctg 912 Ser Leu Arg Lys Ile
Asn Ala Ala Trp Phe Lys Asn Met Pro His Leu 275 280 285 aag gtg ctg
gat ctt gaa ttc aac tat tta gtg gga gaa ata gcc tct 960 Lys Val Leu
Asp Leu Glu Phe Asn Tyr Leu Val Gly Glu Ile Ala Ser 290 295 300 ggg
gca ttt tta acg atg ctg ccc cgc tta gaa ata ctt gac ttg tct 1008
Gly Ala Phe Leu Thr Met Leu Pro Arg Leu Glu Ile Leu Asp Leu Ser 305
310 315 320 ttt aac tat ata aag ggg agt tat cca cag cat att aat att
tcc aga 1056 Phe Asn Tyr Ile Lys Gly Ser Tyr Pro Gln His Ile Asn
Ile Ser Arg 325 330 335 aac ttc tct aaa ctt ttg tct cta cgg gca ttg
cat tta aga ggt tat 1104 Asn Phe Ser Lys Leu Leu Ser Leu Arg Ala
Leu His Leu Arg Gly Tyr 340 345 350 gtg ttc cag gaa ctc aga gaa gat
gat ttc cag ccc ctg atg cag ctt 1152 Val Phe Gln Glu Leu Arg Glu
Asp Asp Phe Gln Pro Leu Met Gln Leu 355 360 365 cca aac tta tcg act
atc aac ttg ggt att aat ttt att aag caa atc 1200 Pro Asn Leu Ser
Thr Ile Asn Leu Gly Ile Asn Phe Ile Lys Gln Ile 370 375 380 gat ttc
aaa ctt ttc caa aat ttc tcc aat ctg gaa att att tac ttg 1248 Asp
Phe Lys Leu Phe Gln Asn Phe Ser Asn Leu Glu Ile Ile Tyr Leu 385 390
395 400 tca gaa aac aga ata tca ccg ttg gta aaa gat acc cgg cag agt
tat 1296 Ser Glu Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln
Ser Tyr 405 410 415 gca aat agt tcc tct ttt caa cgt cat atc cgg aaa
cga cgc tca aca 1344 Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg
Lys Arg Arg Ser Thr 420 425 430 gat ttt gag ttt gac cca cat tcg aac
ttt tat cat ttc acc cgt cct 1392 Asp Phe Glu Phe Asp Pro His Ser
Asn Phe Tyr His Phe Thr Arg Pro 435 440 445 tta ata aag cca caa tgt
gct gct tat gga aaa gcc tta gat tta agc 1440 Leu Ile Lys Pro Gln
Cys Ala Ala Tyr Gly Lys Ala Leu Asp Leu Ser 450 455 460 ctc aac agt
att ttc ttc att ggg cca aac caa ttt gaa aat ctt cct 1488 Leu Asn
Ser Ile Phe Phe Ile Gly Pro Asn Gln Phe Glu Asn Leu Pro 465 470 475
480 gac att gcc tgt tta aat ctg tct gca aat agc aat gct caa gtg tta
1536 Asp Ile Ala Cys Leu Asn Leu Ser Ala Asn Ser Asn Ala Gln Val
Leu 485 490 495 agt gga act gaa ttt tca gcc att cct cat gtc aaa tat
ttg gat ttg 1584 Ser Gly Thr Glu Phe Ser Ala Ile Pro His Val Lys
Tyr Leu Asp Leu 500 505 510 aca aac aat aga cta gac ttt gat aat gct
agt gct ctt act gaa ttg 1632 Thr Asn Asn Arg Leu Asp Phe Asp Asn
Ala Ser Ala Leu Thr Glu Leu 515 520 525 tcc gac ttg gaa gtt cta gat
ctc agc tat aat tca cac tat ttc aga 1680 Ser Asp Leu Glu Val Leu
Asp Leu Ser Tyr Asn Ser His Tyr Phe Arg 530 535 540 ata gca ggc gta
aca cat cat cta gaa ttt att caa aat ttc aca aat 1728 Ile Ala Gly
Val Thr His His Leu Glu Phe Ile Gln Asn Phe Thr Asn 545 550 555 560
cta aaa gtt tta aac ttg agc cac aac aac att tat act tta aca gat
1776 Leu Lys Val Leu Asn Leu Ser His Asn Asn Ile Tyr Thr Leu Thr
Asp 565 570 575 aag tat aac ctg gaa agc aag tcc ctg gta gaa tta gtt
ttc agt ggc 1824 Lys Tyr Asn Leu Glu Ser Lys Ser Leu Val Glu Leu
Val Phe Ser Gly 580 585 590 aat cgc ctt gac att ttg tgg aat gat gat
gac aac agg tat atc tcc 1872 Asn Arg Leu Asp Ile Leu Trp Asn Asp
Asp Asp Asn Arg Tyr Ile Ser 595 600 605 att ttc aaa ggt ctc aag aat
ctg aca cgt ctg gat tta tcc ctt aat 1920 Ile Phe Lys Gly Leu Lys
Asn Leu Thr Arg Leu Asp Leu Ser Leu Asn 610 615 620 agg ctc aag cac
atc cca aat gaa gca ttc ctt aat ttg cca gcg agt 1968 Arg Leu Lys
His Ile Pro Asn Glu Ala Phe Leu Asn Leu Pro Ala Ser 625 630 635 640
ctc act gaa cta cat ata aat gat aat atg tta aag ttt ttt aac tgg
2016 Leu Thr Glu Leu His Ile Asn Asp Asn Met Leu Lys Phe Phe Asn
Trp 645 650 655 aca tta ctc cag cag ttt cct cgt ctc gag ttg ctt gac
tta cgt gga 2064 Thr Leu Leu Gln Gln Phe Pro Arg Leu Glu Leu Leu
Asp Leu Arg Gly 660 665 670 aac aaa cta ctc ttt tta act gat agc cta
tct gac ttt aca tct tcc 2112 Asn Lys Leu Leu Phe Leu Thr Asp Ser
Leu Ser Asp Phe Thr Ser Ser 675 680 685 ctt cgg aca ctg ctg ctg agt
cat aac agg att tcc cac cta ccc tct 2160 Leu Arg Thr Leu Leu Leu
Ser His Asn Arg Ile Ser His Leu Pro Ser 690 695 700 ggc ttt ctt tct
gaa gtc agt agt ctg aag cac ctc gat tta agt tcc 2208 Gly Phe Leu
Ser Glu Val Ser Ser Leu Lys His Leu Asp Leu Ser Ser 705 710 715 720
aat ctg cta aaa aca atm aac aaa tcc gca ctt gaa act aag acc acc
2256 Asn Leu Leu Lys Thr Xaa Asn Lys Ser Ala Leu Glu Thr Lys Thr
Thr 725 730 735 acc aaa tta tct atg ttg gaa cta cac gga aac ccc ttt
gaa tgc acc 2304 Thr Lys Leu Ser Met Leu Glu Leu His Gly Asn Pro
Phe Glu Cys Thr 740 745 750 tgt gac att gga gat ttc cga aga tgg atg
gat gaa cat ctg aat gtc 2352 Cys Asp Ile Gly Asp Phe Arg Arg Trp
Met Asp Glu His Leu Asn Val 755 760 765 aaa att ccc aga ctg gta gat
gtc att tgt gcc agt cct ggg gat caa 2400 Lys Ile Pro Arg Leu Val
Asp Val Ile Cys Ala Ser Pro Gly Asp Gln 770 775 780 aga ggg aag agt
att gtg agt ctg gag cta aca act tgt gtt tca gat 2448 Arg Gly Lys
Ser Ile Val Ser Leu Glu Leu Thr Thr Cys Val Ser Asp 785 790 795 800
gtc act gca gtg ata tta ttt ttc ttc acg ttc ttt atc acc acc atg
2496 Val Thr Ala Val Ile Leu Phe Phe Phe Thr Phe Phe Ile Thr Thr
Met 805 810 815 gtt atg ttg gct gcc ctg gct cac cat ttg ttt tac tgg
gat gtt tgg 2544 Val Met Leu Ala Ala Leu Ala His His Leu Phe Tyr
Trp Asp Val Trp 820 825 830 ttt ata tat aat gtg tgt tta gct aag tta
aaa ggc tac agg tct ctt 2592 Phe Ile Tyr Asn Val Cys Leu Ala Lys
Leu Lys Gly Tyr Arg Ser Leu 835 840 845 tcc aca tcc caa act ttc tat
gat gct tac att tct tat gac acc aaa 2640 Ser Thr Ser Gln Thr Phe
Tyr Asp Ala Tyr Ile Ser Tyr Asp Thr Lys 850 855 860 gat gcc tct gtt
act gac tgg gtg ata aat gag ctg cgc tac cac ctt 2688 Asp Ala Ser
Val Thr Asp Trp Val Ile Asn Glu Leu Arg Tyr His Leu 865 870 875 880
gaa gag agc cga gac aaa aac gtt ctc ctt tgt cta gag gag agg gat
2736 Glu Glu Ser Arg Asp Lys Asn Val Leu Leu Cys Leu Glu Glu Arg
Asp 885 890 895 tgg gac ccg gga ttg gcc atc atc gac aac ctc atg cag
agc atc aac 2784 Trp Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met
Gln Ser Ile Asn 900 905 910 caa agc aag aaa aca gta ttt gtt tta acc
aaa aaa tat gca aaa agc 2832 Gln Ser Lys Lys Thr Val Phe Val Leu
Thr Lys Lys Tyr Ala Lys Ser 915 920 925 tgg aac ttt aaa aca gct ttt
tac ttg gcc ttg cag agg cta atg ggt 2880 Trp Asn Phe Lys Thr Ala
Phe Tyr Leu Ala Leu Gln Arg Leu Met Gly 930 935 940 gag aac atg gat
gtg att ata ttt atc ctg ctg gag cca gtg tta cag 2928 Glu Asn Met
Asp Val Ile Ile Phe Ile Leu Leu Glu Pro Val Leu Gln 945 950 955 960
cat tct ccg tat ttg agg cta cgg cag cgg atc tgt aag agc tcc atc
2976 His Ser Pro Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys Ser Ser
Ile 965 970 975 ctc cag tgg cct gac aac ccg aag gca gaa ggc ttg ttt
tgg caa act 3024 Leu Gln Trp Pro Asp Asn Pro Lys Ala Glu Gly Leu
Phe Trp Gln Thr 980 985 990 ctg aga aat gtg gtc ttg act gaa aat gat
tca cgg tat aac aat atg 3072 Leu Arg Asn Val Val Leu Thr Glu Asn
Asp Ser Arg Tyr Asn Asn Met 995 1000 1005 tat gtc gat tcc att aag
caa tac taa 3099 Tyr Val Asp Ser Ile Lys Gln Tyr 1010 1015
<210> SEQ ID NO 37 <211> LENGTH: 1032 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (725)..(725)
<223> OTHER INFORMATION: Ile <400> SEQUENCE: 37 Met Leu
Thr Cys Ile Phe Leu Leu Ile Ser Gly Ser Cys Glu Leu Cys -15 -10 -5
-1 1 Ala Glu Glu Asn Phe Ser Arg Ser Tyr Pro Cys Asp Glu Lys Lys
Gln 5 10 15 Asn Asp Ser Val Ile Ala Glu Cys Ser Asn Arg Arg Leu Gln
Glu Val 20 25 30 Pro Gln Thr Val Gly Lys Tyr Val Thr Glu Leu Asp
Leu Ser Asp Asn 35 40 45 Phe Ile Thr His Ile Thr Asn Glu Ser Phe
Gln Gly Leu Gln Asn Leu 50 55 60 Thr Lys Ile Asn Leu Asn His Asn
Pro Asn Val Gln His Gln Asn Gly 65 70 75 80 Asn Pro Gly Ile Gln Ser
Asn Gly Leu Asn Ile Thr Asp Gly Ala Phe 85 90 95 Leu Asn Leu Lys
Asn Leu Arg Glu Leu Leu Leu Glu Asp Asn Gln Leu 100 105 110 Pro Gln
Ile Pro Ser Gly Leu Pro Glu Ser Leu Thr Glu Leu Ser Leu 115 120 125
Ile Gln Asn Asn Ile Tyr Asn Ile Thr Lys Glu Gly Ile Ser Arg Leu 130
135 140 Ile Asn Leu Lys Asn Leu Tyr Leu Ala Trp Asn Cys Tyr Phe Asn
Lys 145 150 155 160 Val Cys Glu Lys Thr Asn Ile Glu Asp Gly Val Phe
Glu Thr Leu Thr 165 170 175 Asn Leu Glu Leu Leu Ser Leu Ser Phe Asn
Ser Leu Ser His Val Pro 180 185 190 Pro Lys Leu Pro Ser Ser Leu Arg
Lys Leu Phe Leu Ser Asn Thr Gln 195 200 205 Ile Lys Tyr Ile Ser Glu
Glu Asp Phe Lys Gly Leu Ile Asn Leu Thr 210 215 220 Leu Leu Asp Leu
Ser Gly Asn Cys Pro Arg Cys Phe Asn Ala Pro Phe 225 230 235 240 Pro
Cys Val Pro Cys Asp Gly Gly Ala Ser Ile Asn Ile Asp Arg Phe 245 250
255 Ala Phe Gln Asn Leu Thr Gln Leu Arg Tyr Leu Asn Leu Ser Ser Thr
260 265 270 Ser Leu Arg Lys Ile Asn Ala Ala Trp Phe Lys Asn Met Pro
His Leu 275 280 285 Lys Val Leu Asp Leu Glu Phe Asn Tyr Leu Val Gly
Glu Ile Ala Ser 290 295 300 Gly Ala Phe Leu Thr Met Leu Pro Arg Leu
Glu Ile Leu Asp Leu Ser 305 310 315 320 Phe Asn Tyr Ile Lys Gly Ser
Tyr Pro Gln His Ile Asn Ile Ser Arg 325 330 335 Asn Phe Ser Lys Leu
Leu Ser Leu Arg Ala Leu His Leu Arg Gly Tyr 340 345 350 Val Phe Gln
Glu Leu Arg Glu Asp Asp Phe Gln Pro Leu Met Gln Leu 355 360 365 Pro
Asn Leu Ser Thr Ile Asn Leu Gly Ile Asn Phe Ile Lys Gln Ile 370 375
380 Asp Phe Lys Leu Phe Gln Asn Phe Ser Asn Leu Glu Ile Ile Tyr Leu
385 390 395 400 Ser Glu Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg
Gln Ser Tyr 405 410 415 Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg
Lys Arg Arg Ser Thr 420 425 430 Asp Phe Glu Phe Asp Pro His Ser Asn
Phe Tyr His Phe Thr Arg Pro 435 440 445 Leu Ile Lys Pro Gln Cys Ala
Ala Tyr Gly Lys Ala Leu Asp Leu Ser 450 455 460 Leu Asn Ser Ile Phe
Phe Ile Gly Pro Asn Gln Phe Glu Asn Leu Pro 465 470 475 480 Asp Ile
Ala Cys Leu Asn Leu Ser Ala Asn Ser Asn Ala Gln Val Leu 485 490 495
Ser Gly Thr Glu Phe Ser Ala Ile Pro His Val Lys Tyr Leu Asp Leu 500
505 510 Thr Asn Asn Arg Leu Asp Phe Asp Asn Ala Ser Ala Leu Thr Glu
Leu 515 520 525 Ser Asp Leu Glu Val Leu Asp Leu Ser Tyr Asn Ser His
Tyr Phe Arg 530 535 540 Ile Ala Gly Val Thr His His Leu Glu Phe Ile
Gln Asn Phe Thr Asn 545 550 555 560 Leu Lys Val Leu Asn Leu Ser His
Asn Asn Ile Tyr Thr Leu Thr Asp 565 570 575 Lys Tyr Asn Leu Glu Ser
Lys Ser Leu Val Glu Leu Val Phe Ser Gly 580 585 590 Asn Arg Leu Asp
Ile Leu Trp Asn Asp Asp Asp Asn Arg Tyr Ile Ser 595 600 605 Ile Phe
Lys Gly Leu Lys Asn Leu Thr Arg Leu Asp Leu Ser Leu Asn 610 615 620
Arg Leu Lys His Ile Pro Asn Glu Ala Phe Leu Asn Leu Pro Ala Ser 625
630 635 640 Leu Thr Glu Leu His Ile Asn Asp Asn Met Leu Lys Phe Phe
Asn Trp 645 650 655 Thr Leu Leu Gln Gln Phe Pro Arg Leu Glu Leu Leu
Asp Leu Arg Gly 660 665 670 Asn Lys Leu Leu Phe Leu Thr Asp Ser Leu
Ser Asp Phe Thr Ser Ser 675 680 685 Leu Arg Thr Leu Leu Leu Ser His
Asn Arg Ile Ser His Leu Pro Ser 690 695 700 Gly Phe Leu Ser Glu Val
Ser Ser Leu Lys His Leu Asp Leu Ser Ser 705 710 715 720 Asn Leu Leu
Lys Thr Xaa Asn Lys Ser Ala Leu Glu Thr Lys Thr Thr 725 730 735 Thr
Lys Leu Ser Met Leu Glu Leu His Gly Asn Pro Phe Glu Cys Thr 740 745
750 Cys Asp Ile Gly Asp Phe Arg Arg Trp Met Asp Glu His Leu Asn Val
755 760 765 Lys Ile Pro Arg Leu Val Asp Val Ile Cys Ala Ser Pro Gly
Asp Gln 770 775 780 Arg Gly Lys Ser Ile Val Ser Leu Glu Leu Thr Thr
Cys Val Ser Asp 785 790 795 800 Val Thr Ala Val Ile Leu Phe Phe Phe
Thr Phe Phe Ile Thr Thr Met 805 810 815 Val Met Leu Ala Ala Leu Ala
His His Leu Phe Tyr Trp Asp Val Trp 820 825 830 Phe Ile Tyr Asn Val
Cys Leu Ala Lys Leu Lys Gly Tyr Arg Ser Leu 835 840 845 Ser Thr Ser
Gln Thr Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp Thr Lys 850 855 860 Asp
Ala Ser Val Thr Asp Trp Val Ile Asn Glu Leu Arg Tyr His Leu 865 870
875 880 Glu Glu Ser Arg Asp Lys Asn Val Leu Leu Cys Leu Glu Glu Arg
Asp 885 890 895 Trp Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln
Ser Ile Asn 900 905 910 Gln Ser Lys Lys Thr Val Phe Val Leu Thr Lys
Lys Tyr Ala Lys Ser 915 920 925 Trp Asn Phe Lys Thr Ala Phe Tyr Leu
Ala Leu Gln Arg Leu Met Gly 930 935 940 Glu Asn Met Asp Val Ile Ile
Phe Ile Leu Leu Glu Pro Val Leu Gln 945 950 955 960 His Ser Pro Tyr
Leu Arg Leu Arg Gln Arg Ile Cys Lys Ser Ser Ile 965 970 975 Leu Gln
Trp Pro Asp Asn Pro Lys Ala Glu Gly Leu Phe Trp Gln Thr 980 985 990
Leu Arg Asn Val Val Leu Thr Glu Asn Asp Ser Arg Tyr Asn Asn Met 995
1000 1005 Tyr Val Asp Ser Ile Lys Gln Tyr 1010 1015 <210> SEQ
ID NO 38 <211> LENGTH: 3046 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (111)..(2543) <220> FEATURE:
<221> NAME/KEY: mat_peptide <222> LOCATION:
(168)..(2543) <400> SEQUENCE: 38 gaatcatcca cgcacctgca
gctctgctga gagagtgcaa gccgtggggg ttttgagctc 60 atcttcatca
ttcatatgag gaaataagtg gtaaaatcct tggaaataca atg aga 116 Met Arg ctc
atc aga aac att tac ata ttt tgt agt att gtt atg aca gca gag 164 Leu
Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr Ala Glu -15 -10
-5 -1 1 ggt gat gct cca gag ctg cca gaa gaa agg gaa ctg atg acc aac
tgc 212 Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr Asn
Cys 5 10 15 tcc aac atg tct cta aga aag gtt ccc gca gac ttg acc cca
gcc aca 260 Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro
Ala Thr 20 25 30 acg aca ctg gat tta tcc tat aac ctc ctt ttt caa
ctc cag agt tca 308 Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln
Leu Gln Ser Ser 35 40 45 gat ttt cat tct gtc tcc aaa ctg aga gtt
ttg att cta tgc cat aac 356 Asp Phe His Ser Val Ser Lys Leu Arg Val
Leu Ile Leu Cys His Asn 50 55 60 aga att caa cag ctg gat ctc aaa
acc ttt gaa ttc aac aag gag tta 404 Arg Ile Gln Gln Leu Asp Leu Lys
Thr Phe Glu Phe Asn Lys Glu Leu 65 70 75 80 aga tat tta gat ttg tct
aat aac aga ctg aag agt gta act tgg tat 452 Arg Tyr Leu Asp Leu Ser
Asn Asn Arg Leu Lys Ser Val Thr Trp Tyr 85 90 95 tta ctg gca ggt
ctc agg tat tta gat ctt tct ttt aat gac ttt gac 500 Leu Leu Ala Gly
Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp Phe Asp 100 105 110 acc atg
cct atc tgt gag gaa gct ggc aac atg tca cac ctg gaa atc 548 Thr Met
Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu Glu Ile 115 120 125
cta ggt ttg agt ggg gca aaa ata caa aaa tca gat ttc cag aaa att 596
Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln Lys Ile 130
135 140 gct cat ctg cat cta aat act gtc ttc tta gga ttc aga act ctt
cct 644 Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr Leu
Pro 145 150 155 160 cat tat gaa gaa ggt agc ctg ccc atc tta aac aca
aca aaa ctg cac 692 His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr
Thr Lys Leu His 165 170 175 att gtt tta cca atg gac aca aat ttc tgg
gtt ctt ttg cgt gat gga 740 Ile Val Leu Pro Met Asp Thr Asn Phe Trp
Val Leu Leu Arg Asp Gly 180 185 190 atc aag act tca aaa ata tta gaa
atg aca aat ata gat ggc aaa agc 788 Ile Lys Thr Ser Lys Ile Leu Glu
Met Thr Asn Ile Asp Gly Lys Ser 195 200 205 caa ttt gta agt tat gaa
atg caa cga aat ctt agt tta gaa aat gct 836 Gln Phe Val Ser Tyr Glu
Met Gln Arg Asn Leu Ser Leu Glu Asn Ala 210 215 220 aag aca tcg gtt
cta ttg ctt aat aaa gtt gat tta ctc tgg gac gac 884 Lys Thr Ser Val
Leu Leu Leu Asn Lys Val Asp Leu Leu Trp Asp Asp 225 230 235 240 ctt
ttc ctt atc tta caa ttt gtt tgg cat aca tca gtg gaa cac ttt 932 Leu
Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu His Phe 245 250
255 cag atc cga aat gtg act ttt ggt ggt aag gct tat ctt gac cac aat
980 Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp His Asn
260 265 270 tca ttt gac tac tca aat act gta atg aga act ata aaa ttg
gag cat 1028 Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys
Leu Glu His 275 280 285 gta cat ttc aga gtg ttt tac att caa cag gat
aaa atc tat ttg ctt 1076 Val His Phe Arg Val Phe Tyr Ile Gln Gln
Asp Lys Ile Tyr Leu Leu 290 295 300 ttg acc aaa atg gac ata gaa aac
ctg aca ata tca aat gca caa atg 1124 Leu Thr Lys Met Asp Ile Glu
Asn Leu Thr Ile Ser Asn Ala Gln Met 305 310 315 320 cca cac atg ctt
ttc ccg aat tat cct acg aaa ttc caa tat tta aat 1172 Pro His Met
Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr Leu Asn 325 330 335 ttt
gcc aat aat atc tta aca gac gag ttg ttt aaa aga act atc caa 1220
Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr Ile Gln 340
345 350 ctg cct cac ttg aaa act ctc att ttg aat ggc aat aaa ctg gag
aca 1268 Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu
Glu Thr 355 360 365 ctt tct tta gta agt tgc ttt gct aac aac aca ccc
ttg gaa cac ttg 1316 Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr
Pro Leu Glu His Leu 370 375 380 gat ctg agt caa aat cta tta caa cat
aaa aat gat gaa aat tgc tca 1364 Asp Leu Ser Gln Asn Leu Leu Gln
His Lys Asn Asp Glu Asn Cys Ser 385 390 395 400 tgg cca gaa act gtg
gtc aat atg aat ctg tca tac aat aaa ttg tct 1412 Trp Pro Glu Thr
Val Val Asn Met Asn Leu Ser Tyr Asn Lys Leu Ser 405 410 415 gat tct
gtc ttc agg tgc ttg ccc aaa agt att caa ata ctt gac cta 1460 Asp
Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu Asp Leu 420 425
430 aat aat aac caa atc caa act gta cct aaa gag act att cat ctg atg
1508 Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His Leu
Met 435 440 445 gcc tta cga gaa cta aat att gca ttt aat ttt cta act
gat ctc cct 1556 Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu
Thr Asp Leu Pro 450 455 460 gga tgc agt cat ttc agt aga ctt tca gtt
ctg aac att gaa atg aac 1604 Gly Cys Ser His Phe Ser Arg Leu Ser
Val Leu Asn Ile Glu Met Asn 465 470 475 480 ttc att ctc agc cca tct
ctg gat ttt gtt cag agc tgc cag gaa gtt 1652 Phe Ile Leu Ser Pro
Ser Leu Asp Phe Val Gln Ser Cys Gln Glu Val 485 490 495 aaa act cta
aat gcg gga aga aat cca ttc cgg tgt acc tgt gaa tta 1700 Lys Thr
Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys Glu Leu 500 505 510
aaa aat ttc att cag ctt gaa aca tat tca gag gtc atg atg gtt gga
1748 Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met Val
Gly 515 520 525 tgg tca gat tca tac acc tgt gaa tac cct tta aac cta
agg gga act 1796 Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn
Leu Arg Gly Thr 530 535 540 agg tta aaa gac gtt cat ctc cac gaa tta
tct tgc aac aca gct ctg 1844 Arg Leu Lys Asp Val His Leu His Glu
Leu Ser Cys Asn Thr Ala Leu 545 550 555 560 ttg att gtc acc att gtg
gtt att atg cta gtt ctg ggg ttg gct gtg 1892 Leu Ile Val Thr Ile
Val Val Ile Met Leu Val Leu Gly Leu Ala Val 565 570 575 gcc ttc tgc
tgt ctc cac ttt gat ctg ccc tgg tat ctc agg atg cta 1940 Ala Phe
Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg Met Leu 580 585 590
ggt caa tgc aca caa aca tgg cac agg gtt agg aaa aca acc caa gaa
1988 Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr Gln
Glu 595 600 605 caa ctc aag aga aat gtc cga ttc cac gca ttt att tca
tac agt gaa 2036 Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile
Ser Tyr Ser Glu 610 615 620 cat gat tct ctg tgg gtg aag aat gaa ttg
atc ccc aat cta gag aag 2084 His Asp Ser Leu Trp Val Lys Asn Glu
Leu Ile Pro Asn Leu Glu Lys 625 630 635 640 gaa gat ggt tct atc ttg
att tgc ctt tat gaa agc tac ttt gac cct 2132 Glu Asp Gly Ser Ile
Leu Ile Cys Leu Tyr Glu Ser Tyr Phe Asp Pro 645 650 655 ggc aaa agc
att agt gaa aat att gta agc ttc att gag aaa agc tat 2180 Gly Lys
Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys Ser Tyr 660 665 670
aag tcc atc ttt gtt ttg tct ccc aac ttt gtc cag aat gag tgg tgc
2228 Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu Trp
Cys 675 680 685 cat tat gaa ttc tac ttt gcc cac cac aat ctc ttc cat
gaa aat tct 2276 His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe
His Glu Asn Ser 690 695 700 gat cat ata att ctt atc tta ctg gaa ccc
att cca ttc tat tgc att 2324 Asp His Ile Ile Leu Ile Leu Leu Glu
Pro Ile Pro Phe Tyr Cys Ile 705 710 715 720 ccc acc agg tat cat aaa
ctg aaa gct ctc ctg gaa aaa aaa gca tac 2372 Pro Thr Arg Tyr His
Lys Leu Lys Ala Leu Leu Glu Lys Lys Ala Tyr 725 730 735 ttg gaa tgg
ccc aag gat agg cgt aaa tgt ggg ctt ttc tgg gca aac 2420 Leu Glu
Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp Ala Asn 740 745 750
ctt cga gct gct att aat gtt aat gta tta gcc acc aga gaa atg tat
2468 Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu Met
Tyr 755 760 765 gaa ctg cag aca ttc aca gag tta aat gaa gag tct cga
ggt tct aca 2516 Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser
Arg Gly Ser Thr 770 775 780 atc tct ctg atg aga aca gat tgt cta
taaaatccca cagtccttgg 2563 Ile Ser Leu Met Arg Thr Asp Cys Leu 785
790 gaagttgggg accacataca ctgttgggat gtacattgat acaaccttta
tgatggcaat 2623 ttgacaatat ttattaaaat aaaaaatggt tattcccttc
atatcagttt ctagaaggat 2683 ttctaagaat gtatcctata gaaacacctt
cacaagttta taagggctta tggaaaaagg 2743 tgttcatccc aggattgttt
ataatcatga aaaatgtggc caggtgcagt ggctcactct 2803 tgtaatccca
gcactatggg aggccaaggt gggtgaccca cgaggtcaag agatggagac 2863
catcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctgggcgt
2923 gatggtgcac gcctgtagtc ccagctactt gggaggctga ggcaggagaa
tcgcttgaac 2983 ccgggaggtg gcagttgcag tgagctgaga tcgagccact
gcactccagc ctggtgacag 3043 agc 3046 <210> SEQ ID NO 39
<211> LENGTH: 811 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 39 Met Arg Leu Ile Arg Asn Ile
Tyr Ile Phe Cys Ser Ile Val Met Thr -15 -10 -5 -1 1 Ala Glu Gly Asp
Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 5 10 15 Asn Cys Ser
Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 20 25 30 Ala
Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 35 40
45 Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys
50 55 60 His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe
Asn Lys 65 70 75 80 Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu
Lys Ser Val Thr 85 90 95 Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu
Asp Leu Ser Phe Asn Asp 100 105 110 Phe Asp Thr Met Pro Ile Cys Glu
Glu Ala Gly Asn Met Ser His Leu 115 120 125 Glu Ile Leu Gly Leu Ser
Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 130 135 140 Lys Ile Ala His
Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 145 150 155 160 Leu
Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 165 170
175 Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg
180 185 190 Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile
Asp Gly 195 200 205 Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn
Leu Ser Leu Glu 210 215 220 Asn Ala Lys Thr Ser Val Leu Leu Leu Asn
Lys Val Asp Leu Leu Trp 225 230 235 240 Asp Asp Leu Phe Leu Ile Leu
Gln Phe Val Trp His Thr Ser Val Glu 245 250 255 His Phe Gln Ile Arg
Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 260 265 270 His Asn Ser
Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 275 280 285 Glu
His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 290 295
300 Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala
305 310 315 320 Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys
Phe Gln Tyr 325 330 335 Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu
Leu Phe Lys Arg Thr 340 345 350 Ile Gln Leu Pro His Leu Lys Thr Leu
Ile Leu Asn Gly Asn Lys Leu 355 360 365 Glu Thr Leu Ser Leu Val Ser
Cys Phe Ala Asn Asn Thr Pro Leu Glu 370 375 380 His Leu Asp Leu Ser
Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 385 390 395 400 Cys Ser
Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 405 410 415
Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 420
425 430 Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile
His 435 440 445 Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe
Leu Thr Asp 450 455 460 Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser
Val Leu Asn Ile Glu 465 470 475 480 Met Asn Phe Ile Leu Ser Pro Ser
Leu Asp Phe Val Gln Ser Cys Gln 485 490 495 Glu Val Lys Thr Leu Asn
Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 500 505 510 Glu Leu Lys Asn
Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 515 520 525 Val Gly
Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 530 535 540
Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 545
550 555 560 Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu
Gly Leu 565 570 575 Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro
Trp Tyr Leu Arg 580 585 590 Met Leu Gly Gln Cys Thr Gln Thr Trp His
Arg Val Arg Lys Thr Thr 595 600 605 Gln Glu Gln Leu Lys Arg Asn Val
Arg Phe His Ala Phe Ile Ser Tyr 610 615 620 Ser Glu His Asp Ser Leu
Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 625 630 635 640 Glu Lys Glu
Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 645 650 655 Asp
Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 660 665
670 Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu
675 680 685 Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe
His Glu 690 695 700 Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro
Ile Pro Phe Tyr 705 710 715 720 Cys Ile Pro Thr Arg Tyr His Lys Leu
Lys Ala Leu Leu Glu Lys Lys 725 730 735 Ala Tyr Leu Glu Trp Pro Lys
Asp Arg Arg Lys Cys Gly Leu Phe Trp 740 745 750 Ala Asn Leu Arg Ala
Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 755 760 765 Met Tyr Glu
Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 770 775 780 Ser
Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 785 790 795 <210> SEQ
ID NO 40 <211> LENGTH: 2760 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (68)..(2455) <220> FEATURE:
<221> NAME/KEY: mat_peptide <222> LOCATION:
(161)..(2455) <220> FEATURE: <221> NAME/KEY:
modified_base <222> LOCATION: (2529)..(2529) <223>
OTHER INFORMATION: a, c, t, g, unknown or other <400>
SEQUENCE: 40 aagaatttgg actcatatca agatgctctg aagaagaaca accctttagg
atagccactg 60 caacatc atg acc aaa gac aaa gaa cct att gtt aaa agc
ttc cat ttt 109 Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His
Phe -30 -25 -20 gtt tgc ctt atg atc ata ata gtt gga acc aga atc cag
ttc tcc gac 157 Val Cys Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln
Phe Ser Asp -15 -10 -5 gga aat gaa ttt gca gta gac aag tca aaa aga
ggt ctt att cat gtt 205 Gly Asn Glu Phe Ala Val Asp Lys Ser Lys Arg
Gly Leu Ile His Val -1 1 5 10 15 cca aaa gac cta ccg ctg aaa acc
aaa gtc tta gat atg tct cag aac 253 Pro Lys Asp Leu Pro Leu Lys Thr
Lys Val Leu Asp Met Ser Gln Asn 20 25 30 tac atc gct gag ctt cag
gtc tct gac atg agc ttt cta tca gag ttg 301 Tyr Ile Ala Glu Leu Gln
Val Ser Asp Met Ser Phe Leu Ser Glu Leu 35 40 45 aca gtt ttg aga
ctt tcc cat aac aga atc cag cta ctt gat tta agt 349 Thr Val Leu Arg
Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser 50 55 60 gtt ttc
aag ttc aac cag gat tta gaa tat ttg gat tta tct cat aat 397 Val Phe
Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn 65 70 75
cag ttg caa aag ata tcc tgc cat cct att gtg agt ttc agg cat tta 445
Gln Leu Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu 80
85 90 95 gat ctc tca ttc aat gat ttc aag gcc ctg ccc atc tgt aag
gaa ttt 493 Asp Leu Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys
Glu Phe 100 105 110 ggc aac tta tca caa ctg aat ttc ttg gga ttg agt
gct atg aag ctg 541 Gly Asn Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser
Ala Met Lys Leu 115 120 125 caa aaa tta gat ttg ctg cca att gct cac
ttg cat cta agt tat atc 589 Gln Lys Leu Asp Leu Leu Pro Ile Ala His
Leu His Leu Ser Tyr Ile 130 135 140 ctt ctg gat tta aga aat tat tat
ata aaa gaa aat gag aca gaa agt 637 Leu Leu Asp Leu Arg Asn Tyr Tyr
Ile Lys Glu Asn Glu Thr Glu Ser 145 150 155 160 cta caa att ctg aat
gca aaa acc ctt cac ctt gtt ttt cac cca act 685 Leu Gln Ile Leu Asn
Ala Lys Thr Leu His Leu Val Phe His Pro Thr 165 170 175 agt tta ttc
gct atc caa gtg aac ata tca gtt aat act tta ggg tgc 733 Ser Leu Phe
Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys 180 185 190 tta
caa ctg act aat att aaa ttg aat gat gac aac tgt caa gtt ttc 781 Leu
Gln Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe 195 200
205 att aaa ttt tta tca gaa ctc acc aga ggt cca acc tta ctg aat ttt
829 Ile Lys Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe
210 215 220 acc ctc aac cac ata gaa acg act tgg aaa tgc ctg gtc aga
gtc ttt 877 Thr Leu Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg
Val Phe 225 230 235 240 caa ttt ctt tgg ccc aaa cct gtg gaa tat ctc
aat att tac aat tta 925 Gln Phe Leu Trp Pro Lys Pro Val Glu Tyr Leu
Asn Ile Tyr Asn Leu 245 250 255 aca ata att gaa agc att cgt gaa gaa
gat ttt act tat tct aaa acg 973 Thr Ile Ile Glu Ser Ile Arg Glu Glu
Asp Phe Thr Tyr Ser Lys Thr 260 265 270 aca ttg aaa gca ttg aca ata
gaa cat atc acg aac caa gtt ttt ctg 1021 Thr Leu Lys Ala Leu Thr
Ile Glu His Ile Thr Asn Gln Val Phe Leu 275 280 285 ttt tca cag aca
gct ttg tac acc gtg ttt tct gag atg aac att atg 1069 Phe Ser Gln
Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met 290 295 300 atg
tta acc att tca gat aca cct ttt ata cac atg ctg tgt cct cat 1117
Met Leu Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His 305
310 315 320 gca cca agc aca ttc aag ttt ttg aac ttt acc cag aac gtt
ttc aca 1165 Ala Pro Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn
Val Phe Thr 325 330 335 gat agt att ttt gaa aaa tgt tcc acg tta gtt
aaa ttg gag aca ctt 1213 Asp Ser Ile Phe Glu Lys Cys Ser Thr Leu
Val Lys Leu Glu Thr Leu 340 345 350 atc tta caa aag aat gga tta aaa
gac ctt ttc aaa gta ggt ctc atg 1261 Ile Leu Gln Lys Asn Gly Leu
Lys Asp Leu Phe Lys Val Gly Leu Met 355 360 365 acg aag gat atg cct
tct ttg gaa ata ctg gat gtt agc tgg aat tct 1309 Thr Lys Asp Met
Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser 370 375 380 ttg gaa
tct ggt aga cat aaa gaa aac tgc act tgg gtt gag agt ata 1357 Leu
Glu Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile 385 390
395 400 gtg gtg tta aat ttg tct tca aat atg ctt act gac tct gtt ttc
aga 1405 Val Val Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val
Phe Arg 405 410 415 tgt tta cct ccc agg atc aag gta ctt gat ctt cac
agc aat aaa ata 1453 Cys Leu Pro Pro Arg Ile Lys Val Leu Asp Leu
His Ser Asn Lys Ile 420 425 430 aag agc gtt cct aaa caa gtc gta aaa
ctg gaa gct ttg caa gaa ctc 1501 Lys Ser Val Pro Lys Gln Val Val
Lys Leu Glu Ala Leu Gln Glu Leu 435 440 445 aat gtt gct ttc aat tct
tta act gac ctt cct gga tgt ggc agc ttt 1549 Asn Val Ala Phe Asn
Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe 450 455 460 agc agc ctt
tct gta ttg atc att gat cac aat tca gtt tcc cac cca 1597 Ser Ser
Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro 465 470 475
480 tcg gct gat ttc ttc cag agc tgc cag aag atg agg tca ata aaa gca
1645 Ser Ala Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys
Ala 485 490 495 ggg gac aat cca ttc caa tgt acc tgt gag cta aga gaa
ttt gtc aaa 1693 Gly Asp Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg
Glu Phe Val Lys 500 505 510 aat ata gac caa gta tca agt gaa gtg tta
gag ggc tgg cct gat tct 1741 Asn Ile Asp Gln Val Ser Ser Glu Val
Leu Glu Gly Trp Pro Asp Ser 515 520 525 tat aag tgt gac tac cca gaa
agt tat aga gga agc cca cta aag gac 1789 Tyr Lys Cys Asp Tyr Pro
Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp 530 535 540 ttt cac atg tct
gaa tta tcc tgc aac ata act ctg ctg atc gtc acc 1837 Phe His Met
Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr 545 550 555 560
atc ggt gcc acc atg ctg gtg ttg gct gtg act gtg acc tcc ctc tgc
1885 Ile Gly Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu
Cys 565 570 575 atc tac ttg gat ctg ccc tgg tat ctc agg atg gtg tgc
cag tgg acc 1933 Ile Tyr Leu Asp Leu Pro Trp Tyr Leu Arg Met Val
Cys Gln Trp Thr 580 585 590 cag act cgg cgc agg gcc agg aac ata ccc
tta gaa gaa ctc caa aga 1981 Gln Thr Arg Arg Arg Ala Arg Asn Ile
Pro Leu Glu Glu Leu Gln Arg 595 600 605 aac ctc cag ttt cat gct ttt
att tca tat agt gaa cat gat tct gcc 2029 Asn Leu Gln Phe His Ala
Phe Ile Ser Tyr Ser Glu His Asp Ser Ala 610 615 620 tgg gtg aaa agt
gaa ttg gta cct tac cta gaa aaa gaa gat ata cag 2077 Trp Val Lys
Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln 625 630 635 640
att tgt ctt cat gag agg aac ttt gtc cct ggc aag agc att gtg gaa
2125 Ile Cys Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val
Glu 645 650 655 aat atc atc aac tgc att gag aag agt tac aag tcc atc
ttt gtt ttg 2173 Asn Ile Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser
Ile Phe Val Leu 660 665 670 tct ccc aac ttt gtc cag agt gag tgg tgc
cat tac gaa ctc tat ttt 2221 Ser Pro Asn Phe Val Gln Ser Glu Trp
Cys His Tyr Glu Leu Tyr Phe 675 680 685 gcc cat cac aat ctc ttt cat
gaa gga tct aat aac tta atc ctc atc 2269 Ala His His Asn Leu Phe
His Glu Gly Ser Asn Asn Leu Ile Leu Ile 690 695 700 tta ctg gaa ccc
att cca cag aac agc att ccc aac aag tac cac aag 2317 Leu Leu Glu
Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys 705 710 715 720
ctg aag gct ctc atg acg cag cgg act tat ttg cag tgg ccc aag gag
2365 Leu Lys Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys
Glu 725 730 735 aaa agc aaa cgt ggg ctc ttt tgg gct aac att aga gcc
gct ttt aat 2413 Lys Ser Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg
Ala Ala Phe Asn 740 745 750 atg aaa tta aca cta gtc act gaa aac aat
gat gtg aaa tct 2455 Met Lys Leu Thr Leu Val Thr Glu Asn Asn Asp
Val Lys Ser 755 760 765 taaaaaaatt taggaaattc aacttaagaa accattattt
acttggatga tggtgaatag 2515 tacagtcgta agtnactgtc tggaggtgcc
tccattatcc tcatgccttc aggaaagact 2575 taacaaaaac aatgtttcat
ctggggaact gagctaggcg gtgaggttag cctgccagtt 2635 agagacagcc
cagtctcttc tggtttaatc attatgtttc aaattgaaac agtctctttt 2695
gagtaaatgc tcagtttttc agctcctctc cactctgctt tcccaaatgg attctgttgg
2755 tgaag 2760 <210> SEQ ID NO 41 <211> LENGTH: 796
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 41 Met Thr Lys Asp Lys Glu Pro Ile Val Lys
Ser Phe His Phe Val Cys -30 -25 -20 Leu Met Ile Ile Ile Val Gly Thr
Arg Ile Gln Phe Ser Asp Gly Asn -15 -10 -5 -1 1 Glu Phe Ala Val Asp
Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 5 10 15 Asp Leu Pro Leu
Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 20 25 30 Ala Glu
Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 35 40 45
Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 50
55 60 Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln
Leu 65 70 75 80 Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His
Leu Asp Leu 85 90 95 Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys
Lys Glu Phe Gly Asn 100 105 110 Leu Ser Gln Leu Asn Phe Leu Gly Leu
Ser Ala Met Lys Leu Gln Lys 115 120 125 Leu Asp Leu Leu Pro Ile Ala
His Leu His Leu Ser Tyr Ile Leu Leu 130 135 140 Asp Leu Arg Asn Tyr
Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 145 150 155 160 Ile Leu
Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 165 170 175
Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 180
185 190 Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile
Lys 195 200 205 Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn
Phe Thr Leu 210 215 220 Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val
Arg Val Phe Gln Phe 225 230 235 240 Leu Trp Pro Lys Pro Val Glu Tyr
Leu Asn Ile Tyr Asn Leu Thr Ile 245 250 255 Ile Glu Ser Ile Arg Glu
Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 260 265 270 Lys Ala Leu Thr
Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 275 280 285 Gln Thr
Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 290 295 300
Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 305
310 315 320 Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr
Asp Ser 325 330 335 Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu
Thr Leu Ile Leu 340 345 350 Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys
Val Gly Leu Met Thr Lys 355 360 365 Asp Met Pro Ser Leu Glu Ile Leu
Asp Val Ser Trp Asn Ser Leu Glu 370 375 380 Ser Gly Arg His Lys Glu
Asn Cys Thr Trp Val Glu Ser Ile Val Val 385 390 395 400 Leu Asn Leu
Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 405 410 415 Pro
Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 420 425
430 Val Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val
435 440 445 Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe
Ser Ser 450 455 460 Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser
His Pro Ser Ala 465 470 475 480 Asp Phe Phe Gln Ser Cys Gln Lys Met
Arg Ser Ile Lys Ala Gly Asp 485 490 495 Asn Pro Phe Gln Cys Thr Cys
Glu Leu Arg Glu Phe Val Lys Asn Ile 500 505 510 Asp Gln Val Ser Ser
Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 515 520 525 Cys Asp Tyr
Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 530 535 540 Met
Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 545 550
555 560 Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile
Tyr 565 570 575 Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp
Thr Gln Thr 580 585 590 Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu
Leu Gln Arg Asn Leu 595 600 605 Gln Phe His Ala Phe Ile Ser Tyr Ser
Glu His Asp Ser Ala Trp Val 610 615 620 Lys Ser Glu Leu Val Pro Tyr
Leu Glu Lys Glu Asp Ile Gln Ile Cys 625 630 635 640 Leu His Glu Arg
Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 645 650 655 Ile Asn
Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 660 665 670
Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 675
680 685 His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu
Leu 690 695 700 Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His
Lys Leu Lys 705 710 715 720 Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln
Trp Pro Lys Glu Lys Ser 725 730 735 Lys Arg Gly Leu Phe Trp Ala Asn
Ile Arg Ala Ala Phe Asn Met Lys 740 745 750 Leu Thr Leu Val Thr Glu
Asn Asn Asp Val Lys Ser 755 760 <210> SEQ ID NO 42
<211> LENGTH: 3168 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (1)..(3165) <220> FEATURE:
<221> NAME/KEY: mat_peptide <222> LOCATION:
(145)..(3165) <400> SEQUENCE: 42 atg ccc atg aag tgg agt ggg
tgg agg tgg agc tgg ggg ccg gcc act 48 Met Pro Met Lys Trp Ser Gly
Trp Arg Trp Ser Trp Gly Pro Ala Thr -45 -40 -35 cac aca gcc ctc cca
ccc cca cag ggt ttc tgc cgc agc gcc ctg cac 96 His Thr Ala Leu Pro
Pro Pro Gln Gly Phe Cys Arg Ser Ala Leu His -30 -25 -20 ccg ctg tct
ctc ctg gtg cag gcc atc atg ctg gcc atg acc ctg gcc 144 Pro Leu Ser
Leu Leu Val Gln Ala Ile Met Leu Ala Met Thr Leu Ala -15 -10 -5 -1
ctg ggt acc ttg cct gcc ttc cta ccc tgt gag ctc cag ccc cac ggc 192
Leu Gly Thr Leu Pro Ala Phe Leu Pro Cys Glu Leu Gln Pro His Gly 1 5
10 15 ctg gtg aac tgc aac tgg ctg ttc ctg aag tct gtg ccc cac ttc
tcc 240 Leu Val Asn Cys Asn Trp Leu Phe Leu Lys Ser Val Pro His Phe
Ser 20 25 30 atg gca gca ccc cgt ggc aat gtc acc agc ctt tcc ttg
tcc tcc aac 288 Met Ala Ala Pro Arg Gly Asn Val Thr Ser Leu Ser Leu
Ser Ser Asn 35 40 45 cgc atc cac cac ctc cat gat tct gac ttt gcc
cac ctg ccc agc ctg 336 Arg Ile His His Leu His Asp Ser Asp Phe Ala
His Leu Pro Ser Leu 50 55 60 cgg cat ctc aac ctc aag tgg aac tgc
ccg ccg gtt ggc ctc agc ccc 384 Arg His Leu Asn Leu Lys Trp Asn Cys
Pro Pro Val Gly Leu Ser Pro 65 70 75 80 atg cac ttc ccc tgc cac atg
acc atc gag ccc agc acc ttc ttg gct 432 Met His Phe Pro Cys His Met
Thr Ile Glu Pro Ser Thr Phe Leu Ala 85 90 95 gtg ccc acc ctg gaa
gag cta aac ctg agc tac aac aac atc atg act 480 Val Pro Thr Leu Glu
Glu Leu Asn Leu Ser Tyr Asn Asn Ile Met Thr 100 105 110 gtg cct gcg
ctg ccc aaa tcc ctc ata tcc ctg tcc ctc agc cat acc 528 Val Pro Ala
Leu Pro Lys Ser Leu Ile Ser Leu Ser Leu Ser His Thr 115 120 125 aac
atc ctg atg cta gac tct gcc agc ctc gcc ggc ctg cat gcc ctg 576 Asn
Ile Leu Met Leu Asp Ser Ala Ser Leu Ala Gly Leu His Ala Leu 130 135
140 cgc ttc cta ttc atg gac ggc aac tgt tat tac aag aac ccc tgc agg
624 Arg Phe Leu Phe Met Asp Gly Asn Cys Tyr Tyr Lys Asn Pro Cys Arg
145 150 155 160 cag gca ctg gag gtg gcc ccg ggt gcc ctc ctt ggc ctg
ggc aac ctc 672 Gln Ala Leu Glu Val Ala Pro Gly Ala Leu Leu Gly Leu
Gly Asn Leu 165 170 175 acc cac ctg tca ctc aag tac aac aac ctc act
gtg gtg ccc cgc aac 720 Thr His Leu Ser Leu Lys Tyr Asn Asn Leu Thr
Val Val Pro Arg Asn 180 185 190 ctg cct tcc agc ctg gag tat ctg ctg
ttg tcc tac aac cgc atc gtc 768 Leu Pro Ser Ser Leu Glu Tyr Leu Leu
Leu Ser Tyr Asn Arg Ile Val 195 200 205 aaa ctg gcg cct gag gac ctg
gcc aat ctg acc gcc ctg cgt gtg ctc 816 Lys Leu Ala Pro Glu Asp Leu
Ala Asn Leu Thr Ala Leu Arg Val Leu 210 215 220 gat gtg ggc gga aat
tgc cgc cgc tgc gac cac gct ccc aac ccc tgc 864 Asp Val Gly Gly Asn
Cys Arg Arg Cys Asp His Ala Pro Asn Pro Cys 225 230 235 240 atg gag
tgc cct cgt cac ttc ccc cag cta cat ccc gat acc ttc agc 912 Met Glu
Cys Pro Arg His Phe Pro Gln Leu His Pro Asp Thr Phe Ser 245 250 255
cac ctg agc cgt ctt gaa ggc ctg gtg ttg aag gac agt tct ctc tcc 960
His Leu Ser Arg Leu Glu Gly Leu Val Leu Lys Asp Ser Ser Leu Ser 260
265 270 tgg ctg aat gcc agt tgg ttc cgt ggg ctg gga aac ctc cga gtg
ctg 1008 Trp Leu Asn Ala Ser Trp Phe Arg Gly Leu Gly Asn Leu Arg
Val Leu 275 280 285 gac ctg agt gag aac ttc ctc tac aaa tgc atc act
aaa acc aag gcc 1056 Asp Leu Ser Glu Asn Phe Leu Tyr Lys Cys Ile
Thr Lys Thr Lys Ala 290 295 300 ttc cag ggc cta aca cag ctg cgc aag
ctt aac ctg tcc ttc aat tac 1104 Phe Gln Gly Leu Thr Gln Leu Arg
Lys Leu Asn Leu Ser Phe Asn Tyr 305 310 315 320 caa aag agg gtg tcc
ttt gcc cac ctg tct ctg gcc cct tcc ttc ggg 1152 Gln Lys Arg Val
Ser Phe Ala His Leu Ser Leu Ala Pro Ser Phe Gly 325 330 335 agc ctg
gtc gcc ctg aag gag ctg gac atg cac ggc atc ttc ttc cgc 1200 Ser
Leu Val Ala Leu Lys Glu Leu Asp Met His Gly Ile Phe Phe Arg 340 345
350 tca ctc gat gag acc acg ctc cgg cca ctg gcc cgc ctg ccc atg ctc
1248 Ser Leu Asp Glu Thr Thr Leu Arg Pro Leu Ala Arg Leu Pro Met
Leu 355 360 365 cag act ctg cgt ctg cag atg aac ttc atc aac cag gcc
cag ctc ggc 1296 Gln Thr Leu Arg Leu Gln Met Asn Phe Ile Asn Gln
Ala Gln Leu Gly 370 375 380 atc ttc agg gcc ttc cct ggc ctg cgc tac
gtg gac ctg tcg gac aac 1344 Ile Phe Arg Ala Phe Pro Gly Leu Arg
Tyr Val Asp Leu Ser Asp Asn 385 390 395 400 cgc atc agc gga gct tcg
gag ctg aca gcc acc atg ggg gag gca gat 1392 Arg Ile Ser Gly Ala
Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp 405 410 415 gga ggg gag
aag gtc tgg ctg cag cct ggg gac ctt gct ccg gcc cca 1440 Gly Gly
Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro 420 425 430
gtg gac act ccc agc tct gaa gac ttc agg ccc aac tgc agc acc ctc
1488 Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Cys Ser Thr
Leu 435 440 445 aac ttc acc ttg gat ctg tca cgg aac aac ctg gtg acc
gtg cag ccg 1536 Asn Phe Thr Leu Asp Leu Ser Arg Asn Asn Leu Val
Thr Val Gln Pro 450 455 460 gag atg ttt gcc cag ctc tcg cac ctg cag
tgc ctg cgc ctg agc cac 1584 Glu Met Phe Ala Gln Leu Ser His Leu
Gln Cys Leu Arg Leu Ser His 465 470 475 480 aac tgc atc tcg cag gca
gtc aat ggc tcc cag ttc ctg ccg ctg acc 1632 Asn Cys Ile Ser Gln
Ala Val Asn Gly Ser Gln Phe Leu Pro Leu Thr 485 490 495 ggt ctg cag
gtg cta gac ctg tcc cac aat aag ctg gac ctc tac cac 1680 Gly Leu
Gln Val Leu Asp Leu Ser His Asn Lys Leu Asp Leu Tyr His 500 505 510
gag cac tca ttc acg gag cta cca cga ctg gag gcc ctg gac ctc agc
1728 Glu His Ser Phe Thr Glu Leu Pro Arg Leu Glu Ala Leu Asp Leu
Ser 515 520 525 tac aac agc cag ccc ttt ggc atg cag ggc gtg ggc cac
aac ttc agc 1776 Tyr Asn Ser Gln Pro Phe Gly Met Gln Gly Val Gly
His Asn Phe Ser 530 535 540 ttc gtg gct cac ctg cgc acc ctg cgc cac
ctc agc ctg gcc cac aac 1824 Phe Val Ala His Leu Arg Thr Leu Arg
His Leu Ser Leu Ala His Asn 545 550 555 560 aac atc cac agc caa gtg
tcc cag cag ctc tgc agt acg tcg ctg cgg 1872 Asn Ile His Ser Gln
Val Ser Gln Gln Leu Cys Ser Thr Ser Leu Arg 565 570 575 gcc ctg gac
ttc agc ggc aat gca ctg ggc cat atg tgg gcc gag gga 1920 Ala Leu
Asp Phe Ser Gly Asn Ala Leu Gly His Met Trp Ala Glu Gly 580 585 590
gac ctc tat ctg cac ttc ttc caa ggc ctg agc ggt ttg atc tgg ctg
1968 Asp Leu Tyr Leu His Phe Phe Gln Gly Leu Ser Gly Leu Ile Trp
Leu 595 600 605 gac ttg tcc cag aac cgc ctg cac acc ctc ctg ccc caa
acc ctg cgc 2016 Asp Leu Ser Gln Asn Arg Leu His Thr Leu Leu Pro
Gln Thr Leu Arg 610 615 620 aac ctc ccc aag agc cta cag gtg ctg cgt
ctc cgt gac aat tac ctg 2064 Asn Leu Pro Lys Ser Leu Gln Val Leu
Arg Leu Arg Asp Asn Tyr Leu 625 630 635 640 gcc ttc ttt aag tgg tgg
agc ctc cac ttc ctg ccc aaa ctg gaa gtc 2112 Ala Phe Phe Lys Trp
Trp Ser Leu His Phe Leu Pro Lys Leu Glu Val 645 650 655 ctc gac ctg
gca gga aac cag ctg aag gcc ctg acc aat ggc agc ctg 2160 Leu Asp
Leu Ala Gly Asn Gln Leu Lys Ala Leu Thr Asn Gly Ser Leu 660 665 670
cct gct ggc acc cgg ctc cgg agg ctg gat gtc agc tgc aac agc atc
2208 Pro Ala Gly Thr Arg Leu Arg Arg Leu Asp Val Ser Cys Asn Ser
Ile 675 680 685 agc ttc gtg gcc ccc ggc ttc ttt tcc aag gcc aag gag
ctg cga gag 2256 Ser Phe Val Ala Pro Gly Phe Phe Ser Lys Ala Lys
Glu Leu Arg Glu 690 695 700 ctc aac ctt agc gcc aac gcc ctc aag aca
gtg gac cac tcc tgg ttt 2304 Leu Asn Leu Ser Ala Asn Ala Leu Lys
Thr Val Asp His Ser Trp Phe 705 710 715 720 ggg ccc ctg gcg agt gcc
ctg caa ata cta gat gta agc gcc aac cct 2352 Gly Pro Leu Ala Ser
Ala Leu Gln Ile Leu Asp Val Ser Ala Asn Pro 725 730 735 ctg cac tgc
gcc tgt ggg gcg gcc ttt atg gac ttc ctg ctg gag gtg 2400 Leu His
Cys Ala Cys Gly Ala Ala Phe Met Asp Phe Leu Leu Glu Val 740 745 750
cag gct gcc gtg ccc ggt ctg ccc agc cgg gtg aag tgt ggc agt ccg
2448 Gln Ala Ala Val Pro Gly Leu Pro Ser Arg Val Lys Cys Gly Ser
Pro 755 760 765 ggc cag ctc cag ggc ctc agc atc ttt gca cag gac ctg
cgc ctc tgc 2496 Gly Gln Leu Gln Gly Leu Ser Ile Phe Ala Gln Asp
Leu Arg Leu Cys 770 775 780 ctg gat gag gcc ctc tcc tgg gac tgt ttc
gcc ctc tcg ctg ctg gct 2544 Leu Asp Glu Ala Leu Ser Trp Asp Cys
Phe Ala Leu Ser Leu Leu Ala 785 790 795 800 gtg gct ctg ggc ctg ggt
gtg ccc atg ctg cat cac ctc tgt ggc tgg 2592 Val Ala Leu Gly Leu
Gly Val Pro Met Leu His His Leu Cys Gly Trp 805 810 815 gac ctc tgg
tac tgc ttc cac ctg tgc ctg gcc tgg ctt ccc tgg cgg 2640 Asp Leu
Trp Tyr Cys Phe His Leu Cys Leu Ala Trp Leu Pro Trp Arg 820 825 830
ggg cgg caa agt ggg cga gat gag gat gcc ctg ccc tac gat gcc ttc
2688 Gly Arg Gln Ser Gly Arg Asp Glu Asp Ala Leu Pro Tyr Asp Ala
Phe 835 840 845 gtg gtc ttc gac aaa acg cag agc gca gtg gca gac tgg
gtg tac aac 2736 Val Val Phe Asp Lys Thr Gln Ser Ala Val Ala Asp
Trp Val Tyr Asn 850 855 860 gag ctt cgg ggg cag ctg gag gag tgc cgt
ggg cgc tgg gca ctc cgc 2784 Glu Leu Arg Gly Gln Leu Glu Glu Cys
Arg Gly Arg Trp Ala Leu Arg 865 870 875 880 ctg tgc ctg gag gaa cgc
gac tgg ctg cct ggc aaa acc ctc ttt gag 2832 Leu Cys Leu Glu Glu
Arg Asp Trp Leu Pro Gly Lys Thr Leu Phe Glu 885 890 895 aac ctg tgg
gcc tcg gtc tat ggc agc cgc aag acg ctg ttt gtg ctg 2880 Asn Leu
Trp Ala Ser Val Tyr Gly Ser Arg Lys Thr Leu Phe Val Leu 900 905 910
gcc cac acg gac cgg gtc agt ggt ctc ttg cgc gcc agc ttc ctg ctg
2928 Ala His Thr Asp Arg Val Ser Gly Leu Leu Arg Ala Ser Phe Leu
Leu 915 920 925 gcc cag cag cgc ctg ctg gag gac cgc aag gac gtc gtg
gtg ctg gtg 2976 Ala Gln Gln Arg Leu Leu Glu Asp Arg Lys Asp Val
Val Val Leu Val 930 935 940 atc ctg agc cct gac ggc cgc cgc tcc cgc
tat gtg cgg ctg cgc cag 3024 Ile Leu Ser Pro Asp Gly Arg Arg Ser
Arg Tyr Val Arg Leu Arg Gln 945 950 955 960 cgc ctc tgc cgc cag agt
gtc ctc ctc tgg ccc cac cag ccc agt ggt 3072 Arg Leu Cys Arg Gln
Ser Val Leu Leu Trp Pro His Gln Pro Ser Gly 965 970 975 cag cgc agc
ttc tgg gcc cag ctg ggc atg gcc ctg acc agg gac aac 3120 Gln Arg
Ser Phe Trp Ala Gln Leu Gly Met Ala Leu Thr Arg Asp Asn 980 985 990
cac cac ttc tat aac cgg aac ttc tgc cag gga ccc acg gcc gaa tag
3168 His His Phe Tyr Asn Arg Asn Phe Cys Gln Gly Pro Thr Ala Glu
995 1000 1005 <210> SEQ ID NO 43 <211> LENGTH: 1055
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 43 Met Pro Met Lys Trp Ser Gly Trp Arg Trp
Ser Trp Gly Pro Ala Thr -45 -40 -35 His Thr Ala Leu Pro Pro Pro Gln
Gly Phe Cys Arg Ser Ala Leu His -30 -25 -20 Pro Leu Ser Leu Leu Val
Gln Ala Ile Met Leu Ala Met Thr Leu Ala -15 -10 -5 -1 Leu Gly Thr
Leu Pro Ala Phe Leu Pro Cys Glu Leu Gln Pro His Gly 1 5 10 15 Leu
Val Asn Cys Asn Trp Leu Phe Leu Lys Ser Val Pro His Phe Ser 20 25
30 Met Ala Ala Pro Arg Gly Asn Val Thr Ser Leu Ser Leu Ser Ser Asn
35 40 45 Arg Ile His His Leu His Asp Ser Asp Phe Ala His Leu Pro
Ser Leu 50 55 60 Arg His Leu Asn Leu Lys Trp Asn Cys Pro Pro Val
Gly Leu Ser Pro 65 70 75 80 Met His Phe Pro Cys His Met Thr Ile Glu
Pro Ser Thr Phe Leu Ala 85 90 95 Val Pro Thr Leu Glu Glu Leu Asn
Leu Ser Tyr Asn Asn Ile Met Thr 100 105 110 Val Pro Ala Leu Pro Lys
Ser Leu Ile Ser Leu Ser Leu Ser His Thr 115 120 125 Asn Ile Leu Met
Leu Asp Ser Ala Ser Leu Ala Gly Leu His Ala Leu 130 135 140 Arg Phe
Leu Phe Met Asp Gly Asn Cys Tyr Tyr Lys Asn Pro Cys Arg 145 150 155
160 Gln Ala Leu Glu Val Ala Pro Gly Ala Leu Leu Gly Leu Gly Asn Leu
165 170 175 Thr His Leu Ser Leu Lys Tyr Asn Asn Leu Thr Val Val Pro
Arg Asn 180 185 190 Leu Pro Ser Ser Leu Glu Tyr Leu Leu Leu Ser Tyr
Asn Arg Ile Val 195 200 205 Lys Leu Ala Pro Glu Asp Leu Ala Asn Leu
Thr Ala Leu Arg Val Leu 210 215 220 Asp Val Gly Gly Asn Cys Arg Arg
Cys Asp His Ala Pro Asn Pro Cys 225 230 235 240 Met Glu Cys Pro Arg
His Phe Pro Gln Leu His Pro Asp Thr Phe Ser 245 250 255 His Leu Ser
Arg Leu Glu Gly Leu Val Leu Lys Asp Ser Ser Leu Ser 260 265 270 Trp
Leu Asn Ala Ser Trp Phe Arg Gly Leu Gly Asn Leu Arg Val Leu 275 280
285 Asp Leu Ser Glu Asn Phe Leu Tyr Lys Cys Ile Thr Lys Thr Lys Ala
290 295 300 Phe Gln Gly Leu Thr Gln Leu Arg Lys Leu Asn Leu Ser Phe
Asn Tyr 305 310 315 320 Gln Lys Arg Val Ser Phe Ala His Leu Ser Leu
Ala Pro Ser Phe Gly 325 330 335 Ser Leu Val Ala Leu Lys Glu Leu Asp
Met His Gly Ile Phe Phe Arg 340 345 350 Ser Leu Asp Glu Thr Thr Leu
Arg Pro Leu Ala Arg Leu Pro Met Leu 355 360 365 Gln Thr Leu Arg Leu
Gln Met Asn Phe Ile Asn Gln Ala Gln Leu Gly 370 375 380 Ile Phe Arg
Ala Phe Pro Gly Leu Arg Tyr Val Asp Leu Ser Asp Asn 385 390 395 400
Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp 405
410 415 Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala
Pro 420 425 430 Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Cys
Ser Thr Leu 435 440 445 Asn Phe Thr Leu Asp Leu Ser Arg Asn Asn Leu
Val Thr Val Gln Pro 450 455 460 Glu Met Phe Ala Gln Leu Ser His Leu
Gln Cys Leu Arg Leu Ser His 465 470 475 480 Asn Cys Ile Ser Gln Ala
Val Asn Gly Ser Gln Phe Leu Pro Leu Thr 485 490 495 Gly Leu Gln Val
Leu Asp Leu Ser His Asn Lys Leu Asp Leu Tyr His 500 505 510 Glu His
Ser Phe Thr Glu Leu Pro Arg Leu Glu Ala Leu Asp Leu Ser 515 520 525
Tyr Asn Ser Gln Pro Phe Gly Met Gln Gly Val Gly His Asn Phe Ser 530
535 540 Phe Val Ala His Leu Arg Thr Leu Arg His Leu Ser Leu Ala His
Asn 545 550 555 560 Asn Ile His Ser Gln Val Ser Gln Gln Leu Cys Ser
Thr Ser Leu Arg 565 570 575 Ala Leu Asp Phe Ser Gly Asn Ala Leu Gly
His Met Trp Ala Glu Gly 580 585 590 Asp Leu Tyr Leu His Phe Phe Gln
Gly Leu Ser Gly Leu Ile Trp Leu 595 600 605 Asp Leu Ser Gln Asn Arg
Leu His Thr Leu Leu Pro Gln Thr Leu Arg 610 615 620 Asn Leu Pro Lys
Ser Leu Gln Val Leu Arg Leu Arg Asp Asn Tyr Leu 625 630 635 640 Ala
Phe Phe Lys Trp Trp Ser Leu His Phe Leu Pro Lys Leu Glu Val 645 650
655 Leu Asp Leu Ala Gly Asn Gln Leu Lys Ala Leu Thr Asn Gly Ser Leu
660 665 670 Pro Ala Gly Thr Arg Leu Arg Arg Leu Asp Val Ser Cys Asn
Ser Ile 675 680 685 Ser Phe Val Ala Pro Gly Phe Phe Ser Lys Ala Lys
Glu Leu Arg Glu 690 695 700 Leu Asn Leu Ser Ala Asn Ala Leu Lys Thr
Val Asp His Ser Trp Phe 705 710 715 720 Gly Pro Leu Ala Ser Ala Leu
Gln Ile Leu Asp Val Ser Ala Asn Pro 725 730 735 Leu His Cys Ala Cys
Gly Ala Ala Phe Met Asp Phe Leu Leu Glu Val 740 745 750 Gln Ala Ala
Val Pro Gly Leu Pro Ser Arg Val Lys Cys Gly Ser Pro 755 760 765 Gly
Gln Leu Gln Gly Leu Ser Ile Phe Ala Gln Asp Leu Arg Leu Cys 770 775
780 Leu Asp Glu Ala Leu Ser Trp Asp Cys Phe Ala Leu Ser Leu Leu Ala
785 790 795 800 Val Ala Leu Gly Leu Gly Val Pro Met Leu His His Leu
Cys Gly Trp 805 810 815 Asp Leu Trp Tyr Cys Phe His Leu Cys Leu Ala
Trp Leu Pro Trp Arg 820 825 830 Gly Arg Gln Ser Gly Arg Asp Glu Asp
Ala Leu Pro Tyr Asp Ala Phe 835 840 845 Val Val Phe Asp Lys Thr Gln
Ser Ala Val Ala Asp Trp Val Tyr Asn 850 855 860 Glu Leu Arg Gly Gln
Leu Glu Glu Cys Arg Gly Arg Trp Ala Leu Arg 865 870 875 880 Leu Cys
Leu Glu Glu Arg Asp Trp Leu Pro Gly Lys Thr Leu Phe Glu 885 890 895
Asn Leu Trp Ala Ser Val Tyr Gly Ser Arg Lys Thr Leu Phe Val Leu 900
905 910 Ala His Thr Asp Arg Val Ser Gly Leu Leu Arg Ala Ser Phe Leu
Leu 915 920 925 Ala Gln Gln Arg Leu Leu Glu Asp Arg Lys Asp Val Val
Val Leu Val 930 935 940 Ile Leu Ser Pro Asp Gly Arg Arg Ser Arg Tyr
Val Arg Leu Arg Gln 945 950 955 960 Arg Leu Cys Arg Gln Ser Val Leu
Leu Trp Pro His Gln Pro Ser Gly 965 970 975 Gln Arg Ser Phe Trp Ala
Gln Leu Gly Met Ala Leu Thr Arg Asp Asn 980 985 990 His His Phe Tyr
Asn Arg Asn Phe Cys Gln Gly Pro Thr Ala Glu 995 1000 1005
<210> SEQ ID NO 44 <211> LENGTH: 2289 <212> TYPE:
DNA <213> ORGANISM: Mus musculus <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(2079)
<400> SEQUENCE: 44 aac ctg tcc ttc aat tac cgc aag aag gta
tcc ttt gcc cgc ctc cac 48 Asn Leu Ser Phe Asn Tyr Arg Lys Lys Val
Ser Phe Ala Arg Leu His 1 5 10 15 ctg gca agt tcc ttt aag aac ctg
gtg tca ctg cag gag ctg aac atg 96 Leu Ala Ser Ser Phe Lys Asn Leu
Val Ser Leu Gln Glu Leu Asn Met 20 25 30 aac ggc atc ttc ttc cgc
ttg ctc aac aag tac acg ctc aga tgg ctg 144 Asn Gly Ile Phe Phe Arg
Leu Leu Asn Lys Tyr Thr Leu Arg Trp Leu 35 40 45 gcc gat ctg ccc
aaa ctc cac act ctg cat ctt caa atg aac ttc atc 192 Ala Asp Leu Pro
Lys Leu His Thr Leu His Leu Gln Met Asn Phe Ile 50 55 60 aac cag
gca cag ctc agc atc ttt ggt acc ttc cga gcc ctt cgc ttt 240 Asn Gln
Ala Gln Leu Ser Ile Phe Gly Thr Phe Arg Ala Leu Arg Phe 65 70 75 80
gtg gac ttg tca gac aat cgc atc agt ggg cct tca acg ctg tca gaa 288
Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Pro Ser Thr Leu Ser Glu 85
90 95 gcc acc cct gaa gag gca gat gat gca gag cag gag gag ctg ttg
tct 336 Ala Thr Pro Glu Glu Ala Asp Asp Ala Glu Gln Glu Glu Leu Leu
Ser 100 105 110 gcg gat cct cac cca gct ccg ctg agc acc cct gct tct
aag aac ttc 384 Ala Asp Pro His Pro Ala Pro Leu Ser Thr Pro Ala Ser
Lys Asn Phe 115 120 125 atg gac agg tgt aag aac ttc aag ttc aac atg
gac ctg tct cgg aac 432 Met Asp Arg Cys Lys Asn Phe Lys Phe Asn Met
Asp Leu Ser Arg Asn 130 135 140 aac ctg gtg act atc aca gca gag atg
ttt gta aat ctc tca cgc ctc 480 Asn Leu Val Thr Ile Thr Ala Glu Met
Phe Val Asn Leu Ser Arg Leu 145 150 155 160 cag tgt ctt agc ctg agc
cac aac tca att gca cag gct gtc aat ggc 528 Gln Cys Leu Ser Leu Ser
His Asn Ser Ile Ala Gln Ala Val Asn Gly 165 170 175 tct cag ttc ctg
ccg ctg acc ggt ctg cag gtg cta gac ctg tcc cac 576 Ser Gln Phe Leu
Pro Leu Thr Gly Leu Gln Val Leu Asp Leu Ser His 180 185 190 aat aag
ctg gac ctc tac cac gag cac tca ttc acg gag cta cca cga 624 Asn Lys
Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu Pro Arg 195 200 205
ctg gag gcc ctg gac ctc agc tac aac agc cag ccc ttt agc atg aag 672
Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro Phe Ser Met Lys 210
215 220 ggt ata ggc cac aat ttc agt ttt gtg acc cat ctg tcc atg cta
cag 720 Gly Ile Gly His Asn Phe Ser Phe Val Thr His Leu Ser Met Leu
Gln 225 230 235 240 agc ctt agc ctg gca cac aat gac att cat acc cgt
gtg tcc tca cat 768 Ser Leu Ser Leu Ala His Asn Asp Ile His Thr Arg
Val Ser Ser His 245 250 255 ctc aac agc aac tca gtg agg ttt ctt gac
ttc agc ggc aac ggt atg 816 Leu Asn Ser Asn Ser Val Arg Phe Leu Asp
Phe Ser Gly Asn Gly Met 260 265 270 ggc cgc atg tgg gat gag ggg ggc
ctt tat ctc cat ttc ttc caa ggc 864 Gly Arg Met Trp Asp Glu Gly Gly
Leu Tyr Leu His Phe Phe Gln Gly 275 280 285 ctg agt ggc gtg ctg aag
ctg gac ctg tct caa aat aac ctg cat atc 912 Leu Ser Gly Val Leu Lys
Leu Asp Leu Ser Gln Asn Asn Leu His Ile 290 295 300 ctc cgg ccc cag
aac ctt gac aac ctc ccc aag agc ctg aag ctg ctg 960 Leu Arg Pro Gln
Asn Leu Asp Asn Leu Pro Lys Ser Leu Lys Leu Leu 305 310 315 320 agc
ctc cga gac aac tac cta tct ttc ttt aac tgg acc agt ctg tcc 1008
Ser Leu Arg Asp Asn Tyr Leu Ser Phe Phe Asn Trp Thr Ser Leu Ser 325
330 335 ttc cta ccc aac ctg gaa gtc cta gac ctg gca ggc aac cag cta
aag 1056 Phe Leu Pro Asn Leu Glu Val Leu Asp Leu Ala Gly Asn Gln
Leu Lys 340 345 350 gcc ctg acc aat ggc acc ctg cct aat ggc acc ctc
ctc cag aaa ctc 1104 Ala Leu Thr Asn Gly Thr Leu Pro Asn Gly Thr
Leu Leu Gln Lys Leu 355 360 365 gat gtc agt agc aac agt atc gtc tct
gtg gcc ccc ggc ttc ttt tcc 1152 Asp Val Ser Ser Asn Ser Ile Val
Ser Val Ala Pro Gly Phe Phe Ser 370 375 380 aag gcc aag gag ctg cga
gag ctc aac ctt agc gcc aac gcc ctc aag 1200 Lys Ala Lys Glu Leu
Arg Glu Leu Asn Leu Ser Ala Asn Ala Leu Lys 385 390 395 400 aca gtg
gac cac tcc tgg ttt ggg ccc att gtg atg aac ctg aca gtt 1248 Thr
Val Asp His Ser Trp Phe Gly Pro Ile Val Met Asn Leu Thr Val 405 410
415 cta gac gtg aga agc aac cct ctg cac tgt gcc tgt ggg gca gcc ttc
1296 Leu Asp Val Arg Ser Asn Pro Leu His Cys Ala Cys Gly Ala Ala
Phe 420 425 430 gta gac tta ctg ttg gag gtg cag acc aag gtg cct ggc
ctg gct aat 1344 Val Asp Leu Leu Leu Glu Val Gln Thr Lys Val Pro
Gly Leu Ala Asn 435 440 445 ggt gtg aag tgt ggc agc ccc ggc cag ctg
cag ggc cgt agc atc ttc 1392 Gly Val Lys Cys Gly Ser Pro Gly Gln
Leu Gln Gly Arg Ser Ile Phe 450 455 460 gcg cag gac ctg cgg ctg tgc
ctg gat gag gtc ctc tct tgg gac tgc 1440 Ala Gln Asp Leu Arg Leu
Cys Leu Asp Glu Val Leu Ser Trp Asp Cys 465 470 475 480 ttt ggc ctt
tca ctc ttg gct gtg gcc gtg ggc atg gtg gtg cct ata 1488 Phe Gly
Leu Ser Leu Leu Ala Val Ala Val Gly Met Val Val Pro Ile 485 490 495
ctg cac cat ctc tgc ggc tgg gac gtc tgg tac tgt ttt cat ctg tgc
1536 Leu His His Leu Cys Gly Trp Asp Val Trp Tyr Cys Phe His Leu
Cys 500 505 510 ctg gca tgg cta cct ttg cta gcc cgc agc cga cgc agc
gcc caa act 1584 Leu Ala Trp Leu Pro Leu Leu Ala Arg Ser Arg Arg
Ser Ala Gln Thr 515 520 525 ctc cct tat gat gcc ttc gtg gtg ttc gat
aag gca cag agc gca gtt 1632 Leu Pro Tyr Asp Ala Phe Val Val Phe
Asp Lys Ala Gln Ser Ala Val 530 535 540 gcc gac tgg gtg tat aac gag
ctg cgg gtg cgg ctg gag gag cgg cgc 1680 Ala Asp Trp Val Tyr Asn
Glu Leu Arg Val Arg Leu Glu Glu Arg Arg 545 550 555 560 ggc cgc tgg
gca ctc cgc ctg tgc ctg gag gac cga gat tgg ctg cct 1728 Gly Arg
Trp Ala Leu Arg Leu Cys Leu Glu Asp Arg Asp Trp Leu Pro 565 570 575
ggc cag acg ctc ttc gag aac ctc tgg gct tcc atc tat ggg agc cgc
1776 Gly Gln Thr Leu Phe Glu Asn Leu Trp Ala Ser Ile Tyr Gly Ser
Arg 580 585 590 aag act cta ttt gtg ctg gcc cac acg gac cgc gtc agt
ggc ctc ctg 1824 Lys Thr Leu Phe Val Leu Ala His Thr Asp Arg Val
Ser Gly Leu Leu 595 600 605 cgc acc agc ttc ctg ctg gct cag cag cgc
ctg ttg gaa gac cgc aag 1872 Arg Thr Ser Phe Leu Leu Ala Gln Gln
Arg Leu Leu Glu Asp Arg Lys 610 615 620 gac gtg gtg gtg ttg gtg atc
ctg cgt ccg gat gcc cac cgc tcc cgc 1920 Asp Val Val Val Leu Val
Ile Leu Arg Pro Asp Ala His Arg Ser Arg 625 630 635 640 tat gtg cga
ctg cgc cag cgt ctc tgc cgc cag agt gtg ctc ttc tgg 1968 Tyr Val
Arg Leu Arg Gln Arg Leu Cys Arg Gln Ser Val Leu Phe Trp 645 650 655
ccc cag cag ccc aac ggg cag ggg ggc ttc tgg gcc cag ctg agt aca
2016 Pro Gln Gln Pro Asn Gly Gln Gly Gly Phe Trp Ala Gln Leu Ser
Thr 660 665 670 gcc ctg act agg gac aac cgc cac ttc tat aac cag aac
ttc tgc cgg 2064 Ala Leu Thr Arg Asp Asn Arg His Phe Tyr Asn Gln
Asn Phe Cys Arg 675 680 685 gga cct aca gca gaa tagctcagag
caacagctgg aaacagctgc atcttcatgt 2119 Gly Pro Thr Ala Glu 690
ctggttcccg agttgctctg cctgccttgc tctgtcttac tacaccgcta tttggcaagt
2179 gcgcaatata tgctaccaag ccaccaggcc cacggagcaa aggttggctg
taaagggtag 2239 ttttcttccc atgcatcttt caggagagtg aagatagaca
ccaaacccac 2289 <210> SEQ ID NO 45 <211> LENGTH: 693
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 45 Asn Leu Ser Phe Asn Tyr Arg Lys Lys Val
Ser Phe Ala Arg Leu His 1 5 10 15 Leu Ala Ser Ser Phe Lys Asn Leu
Val Ser Leu Gln Glu Leu Asn Met 20 25 30 Asn Gly Ile Phe Phe Arg
Leu Leu Asn Lys Tyr Thr Leu Arg Trp Leu 35 40 45 Ala Asp Leu Pro
Lys Leu His Thr Leu His Leu Gln Met Asn Phe Ile 50 55 60 Asn Gln
Ala Gln Leu Ser Ile Phe Gly Thr Phe Arg Ala Leu Arg Phe 65 70 75 80
Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Pro Ser Thr Leu Ser Glu 85
90 95 Ala Thr Pro Glu Glu Ala Asp Asp Ala Glu Gln Glu Glu Leu Leu
Ser 100 105 110 Ala Asp Pro His Pro Ala Pro Leu Ser Thr Pro Ala Ser
Lys Asn Phe 115 120 125 Met Asp Arg Cys Lys Asn Phe Lys Phe Asn Met
Asp Leu Ser Arg Asn 130 135 140 Asn Leu Val Thr Ile Thr Ala Glu Met
Phe Val Asn Leu Ser Arg Leu 145 150 155 160 Gln Cys Leu Ser Leu Ser
His Asn Ser Ile Ala Gln Ala Val Asn Gly 165 170 175 Ser Gln Phe Leu
Pro Leu Thr Gly Leu Gln Val Leu Asp Leu Ser His 180 185 190 Asn Lys
Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu Pro Arg 195 200 205
Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro Phe Ser Met Lys 210
215 220 Gly Ile Gly His Asn Phe Ser Phe Val Thr His Leu Ser Met Leu
Gln 225 230 235 240 Ser Leu Ser Leu Ala His Asn Asp Ile His Thr Arg
Val Ser Ser His 245 250 255 Leu Asn Ser Asn Ser Val Arg Phe Leu Asp
Phe Ser Gly Asn Gly Met 260 265 270 Gly Arg Met Trp Asp Glu Gly Gly
Leu Tyr Leu His Phe Phe Gln Gly 275 280 285 Leu Ser Gly Val Leu Lys
Leu Asp Leu Ser Gln Asn Asn Leu His Ile 290 295 300 Leu Arg Pro Gln
Asn Leu Asp Asn Leu Pro Lys Ser Leu Lys Leu Leu 305 310 315 320 Ser
Leu Arg Asp Asn Tyr Leu Ser Phe Phe Asn Trp Thr Ser Leu Ser 325 330
335 Phe Leu Pro Asn Leu Glu Val Leu Asp Leu Ala Gly Asn Gln Leu Lys
340 345 350 Ala Leu Thr Asn Gly Thr Leu Pro Asn Gly Thr Leu Leu Gln
Lys Leu 355 360 365 Asp Val Ser Ser Asn Ser Ile Val Ser Val Ala Pro
Gly Phe Phe Ser 370 375 380 Lys Ala Lys Glu Leu Arg Glu Leu Asn Leu
Ser Ala Asn Ala Leu Lys 385 390 395 400 Thr Val Asp His Ser Trp Phe
Gly Pro Ile Val Met Asn Leu Thr Val 405 410 415 Leu Asp Val Arg Ser
Asn Pro Leu His Cys Ala Cys Gly Ala Ala Phe 420 425 430 Val Asp Leu
Leu Leu Glu Val Gln Thr Lys Val Pro Gly Leu Ala Asn 435 440 445 Gly
Val Lys Cys Gly Ser Pro Gly Gln Leu Gln Gly Arg Ser Ile Phe 450 455
460 Ala Gln Asp Leu Arg Leu Cys Leu Asp Glu Val Leu Ser Trp Asp Cys
465 470 475 480 Phe Gly Leu Ser Leu Leu Ala Val Ala Val Gly Met Val
Val Pro Ile 485 490 495 Leu His His Leu Cys Gly Trp Asp Val Trp Tyr
Cys Phe His Leu Cys 500 505 510 Leu Ala Trp Leu Pro Leu Leu Ala Arg
Ser Arg Arg Ser Ala Gln Thr 515 520 525 Leu Pro Tyr Asp Ala Phe Val
Val Phe Asp Lys Ala Gln Ser Ala Val 530 535 540 Ala Asp Trp Val Tyr
Asn Glu Leu Arg Val Arg Leu Glu Glu Arg Arg 545 550 555 560 Gly Arg
Trp Ala Leu Arg Leu Cys Leu Glu Asp Arg Asp Trp Leu Pro 565 570 575
Gly Gln Thr Leu Phe Glu Asn Leu Trp Ala Ser Ile Tyr Gly Ser Arg 580
585 590 Lys Thr Leu Phe Val Leu Ala His Thr Asp Arg Val Ser Gly Leu
Leu 595 600 605 Arg Thr Ser Phe Leu Leu Ala Gln Gln Arg Leu Leu Glu
Asp Arg Lys 610 615 620 Asp Val Val Val Leu Val Ile Leu Arg Pro Asp
Ala His Arg Ser Arg 625 630 635 640 Tyr Val Arg Leu Arg Gln Arg Leu
Cys Arg Gln Ser Val Leu Phe Trp 645 650 655 Pro Gln Gln Pro Asn Gly
Gln Gly Gly Phe Trp Ala Gln Leu Ser Thr 660 665 670 Ala Leu Thr Arg
Asp Asn Arg His Phe Tyr Asn Gln Asn Phe Cys Arg 675 680 685 Gly Pro
Thr Ala Glu 690 <210> SEQ ID NO 46 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic primer <400> SEQUENCE: 46
cgtaaaactg gaagctttgc aaga 24 <210> SEQ ID NO 47 <211>
LENGTH: 24 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic primer <400>
SEQUENCE: 47 ccttgggcca ttccaaataa gtcc 24 <210> SEQ ID NO 48
<211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic primer
<400> SEQUENCE: 48 ggccagcaaa ttacctgtgt g 21 <210> SEQ
ID NO 49 <211> LENGTH: 21 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
primer <400> SEQUENCE: 49 ccaggtaggt cttggtgttc a 21
<210> SEQ ID NO 50 <211> LENGTH: 25 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 50 attgggtctg ggaacatttc
tcttc 25 <210> SEQ ID NO 51 <211> LENGTH: 25
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic primer <400> SEQUENCE: 51
gtgagattta aacattcctc ttcgc 25 <210> SEQ ID NO 52 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic primer <400>
SEQUENCE: 52 ctgcaatgga tcaaggacca 20 <210> SEQ ID NO 53
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic primer
<400> SEQUENCE: 53 tcccactcca ggtaagtgtt 20 <210> SEQ
ID NO 54 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
primer <400> SEQUENCE: 54 cattgtatgc actgtcactc 20
<210> SEQ ID NO 55 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 55 ccaccaccat gatgagagca 20
<210> SEQ ID NO 56 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 56 taggtctcat gacgaaggat 20
<210> SEQ ID NO 57 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 57 ggccactgca aataagtccg 20
<210> SEQ ID NO 58 <211> LENGTH: 18 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 58 agtgtctaaa gaacctgg 18
<210> SEQ ID NO 59 <211> LENGTH: 18 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 59 cttggcctta cagaaatg 18
<210> SEQ ID NO 60 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 60 cagaatagca ggcgtaacac
atca 24 <210> SEQ ID NO 61 <211> LENGTH: 24 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic primer <400> SEQUENCE: 61 aatgtcacag
gtgcattcaa aggg 24 <210> SEQ ID NO 62 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic primer <400> SEQUENCE: 62
ttatggactt cctgctggag gtgc 24 <210> SEQ ID NO 63 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic primer <400>
SEQUENCE: 63 ctgcgttttg tcgaagacca 20 <210> SEQ ID NO 64
<211> LENGTH: 24 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic primer
<400> SEQUENCE: 64 caatctagag aaggaagatg gtcc 24 <210>
SEQ ID NO 65 <211> LENGTH: 24 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 65 gcccttataa acttgtgaag
gtgt 24 <210> SEQ ID NO 66 <211> LENGTH: 32 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic primer <400> SEQUENCE: 66 atctggcacc
acaccttcta caatgagctg cg 32 <210> SEQ ID NO 67 <211>
LENGTH: 32 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic primer <400>
SEQUENCE: 67 cgtcatactc ctgcttgctg atccacatct gc 32 <210> SEQ
ID NO 68 <211> LENGTH: 21 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
primer <400> SEQUENCE: 68 ggccagcaaa ttacctgtgt g 21
<210> SEQ ID NO 69 <211> LENGTH: 19 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 69 aggcggacat cctgaacct 19
<210> SEQ ID NO 70 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 70 ctgcaatgga tcaaggacca 20
<210> SEQ ID NO 71 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 71 ttatctgaag gtgttgcaca
ttcc 24 <210> SEQ ID NO 72 <211> LENGTH: 24 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic primer <400> SEQUENCE: 72 ttacctggat
ggaaaccagc tact 24 <210> SEQ ID NO 73 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic primer <400> SEQUENCE: 73
tcaaggctga gaagctgtaa gcta 24 <210> SEQ ID NO 74 <211>
LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic primer <400>
SEQUENCE: 74 tgaagacttc aggcccaact g 21 <210> SEQ ID NO 75
<211> LENGTH: 19 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic primer
<400> SEQUENCE: 75 tgcacggtca ccaggttgt 19 <210> SEQ ID
NO 76 <211> LENGTH: 161 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 76 Thr Asp Gly Lys Thr
Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu Cys 1 5 10 15 Arg Pro Glu
Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu Pro 20 25 30 Arg
Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu Arg 35 40
45 Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His Ser Leu Ile
50 55 60 Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr
Met Ser 65 70 75 80 Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His
Glu Ala Leu Val 85 90 95 Glu Arg Lys Ile Ile Ile Leu Ile Glu Phe
Thr Pro Val Thr Asp Phe 100 105 110 Thr Phe Leu Pro Gln Ser Leu Lys
Leu Leu Lys Ser His Arg Val Leu 115 120 125 Lys Trp Lys Ala Asp Lys
Ser Leu Ser Tyr Asn Ser Arg Phe Trp Lys 130 135 140 Asn Leu Leu Tyr
Leu Met Pro Ala Lys Thr Val Lys Pro Gly Arg Asp 145 150 155 160 Glu
<210> SEQ ID NO 77 <211> LENGTH: 158 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 77 Leu
Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Val 1 5 10
15 Glu Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn
20 25 30 Glu Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu
Pro Gly 35 40 45 Gly Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln
Lys Ser Arg Arg 50 55 60 Leu Leu Val Val Leu Ser Pro Asn Tyr Val
Leu Gln Gly Thr Gln Ala 65 70 75 80 Leu Leu Glu Leu Lys Ala Gly Leu
Glu Asn Met Ala Ser Arg Gly Asn 85 90 95 Ile Asn Val Ile Leu Val
Gln Tyr Lys Ala Val Lys Asp Met Lys Val 100 105 110 Lys Glu Leu Lys
Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys 115 120 125 Gly Glu
Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln 130 135 140
Val Ala Met Pro Val Lys Lys Ser Pro Arg Trp Ser Ser Asn 145 150 155
<210> SEQ ID NO 78 <211> LENGTH: 175 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 78 Asn
Asp Gly Lys Leu Tyr Asp Ala Tyr Ile Ile Tyr Pro Arg Val Phe 1 5 10
15 Arg Gly Ser Ala Ala Gly Thr His Ser Val Glu Tyr Phe Val His His
20 25 30 Thr Leu Pro Asp Val Leu Glu Asn Lys Cys Gly Tyr Lys Leu
Cys Ile 35 40 45 Tyr Gly Arg Asp Leu Leu Pro Gly Gln Asp Ala Ala
Thr Val Val Glu 50 55 60 Ser Ser Ile Gln Asn Ser Arg Arg Gln Val
Phe Val Leu Ala Pro His 65 70 75 80 Met Met His Ser Lys Glu Phe Ala
Tyr Glu Gln Glu Ile Ala Leu His 85 90 95 Ser Ala Leu Ile Gln Asn
Asn Ser Lys Val Ile Leu Ile Glu Met Glu 100 105 110 Pro Leu Gly Glu
Ala Ser Arg Leu Gln Val Gly Asp Leu Gln Asp Ser 115 120 125 Leu Gln
His Leu Val Lys Ile Gln Gly Thr Ile Lys Trp Arg Glu Asp 130 135 140
His Val Ala Asp Lys Gln Ser Leu Ser Ser Lys Phe Trp Lys His Val 145
150 155 160 Arg Tyr Gln Met Pro Val Pro Glu Arg Ala Ser Lys Thr Ala
Ser 165 170 175 <210> SEQ ID NO 79 <211> LENGTH: 170
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 79 Val Asp Gly Lys Leu Tyr Asp Ala Tyr Val
Leu Tyr Pro Lys Pro His 1 5 10 15 Lys Glu Ser Gln Arg His Ala Val
Asp Ala Leu Val Leu Asn Ile Leu 20 25 30 Pro Glu Val Leu Glu Arg
Gln Cys Gly Tyr Lys Leu Phe Ile Phe Gly 35 40 45 Arg Asp Glu Phe
Pro Gly Gln Ala Val Ala Asn Val Ile Asp Glu Asn 50 55 60 Val Lys
Leu Cys Arg Arg Leu Ile Val Ile Val Val Pro Glu Ser Leu 65 70 75 80
Gly Phe Gly Leu Leu Lys Asn Leu Ser Glu Glu Gln Ile Ala Val Tyr 85
90 95 Ser Ala Leu Ile Gln Asp Gly Met Lys Val Ile Leu Ile Glu Leu
Glu 100 105 110 Lys Ile Glu Asp Tyr Thr Val Met Pro Glu Ser Ile Gln
Tyr Ile Lys 115 120 125 Gln Lys His Gly Ala Ile Arg Trp His Gly Asp
Phe Thr Glu Gln Ser 130 135 140 Gln Cys Met Lys Thr Lys Phe Trp Lys
Thr Val Arg Tyr His Met Pro 145 150 155 160 Pro Arg Arg Cys Arg Pro
Phe Leu Arg Ser 165 170 <210> SEQ ID NO 80 <211>
LENGTH: 170 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 80 Ser Asp Gly Lys Thr Tyr Asp Ala
Tyr Ile Leu Tyr Pro Lys Thr Val 1 5 10 15 Gly Glu Gly Ser Thr Ser
Asp Cys Asp Ile Phe Val Phe Lys Val Leu 20 25 30 Pro Glu Val Leu
Glu Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly 35 40 45 Arg Asp
Asp Tyr Val Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn 50 55 60
Val Lys Lys Ser Arg Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser 65
70 75 80 Gly Phe Ser Trp Leu Gly Gly Ser Ser Glu Glu Gln Ile Ala
Met Tyr 85 90 95 Asn Ala Leu Val Gln Asp Gly Ile Lys Val Val Leu
Leu Glu Leu Glu 100 105 110 Lys Ile Gln Asp Tyr Glu Lys Met Pro Glu
Ser Ile Lys Phe Ile Lys 115 120 125 Gln Lys His Gly Ala Ile Arg Trp
Ser Gly Asp Phe Thr Gln Gly Pro 130 135 140 Gln Ser Ala Lys Thr Arg
Phe Trp Lys Asn Val Arg Tyr His Met Pro 145 150 155 160 Val Gln Arg
Arg Ser Pro Ser Ser Lys His 165 170 <210> SEQ ID NO 81
<211> LENGTH: 169 <212> TYPE: PRT <213> ORGANISM:
Gallus gallus <400> SEQUENCE: 81 Ser Asp Gly Lys Ile Tyr Asp
Ala Tyr Val Leu Tyr Pro Lys Asn Arg 1 5 10 15 Glu Ser Cys Leu Tyr
Ser Ser Asp Ile Phe Ala Leu Lys Ile Leu Pro 20 25 30 Glu Val Leu
Glu Arg Gln Cys Gly Tyr Asn Leu Phe Ile Phe Gly Arg 35 40 45 Asn
Asp Leu Ala Gly Glu Ala Val Ile Asp Val Thr Asp Glu Lys Ile 50 55
60 His Gln Ser Arg Arg Val Ile Ile Ile Leu Val Pro Glu Pro Ser Cys
65 70 75 80 Tyr Gly Ile Leu Glu Asp Ala Ser Glu Lys His Leu Ala Val
Tyr Asn 85 90 95 Ala Leu Ile Gln Asp Gly Ile Lys Ile Ile Leu Ile
Glu Leu Glu Lys 100 105 110 Ile Glu Asp Tyr Ala Asn Met Pro Glu Ser
Ile Lys Tyr Val Lys Gln 115 120 125 Lys Tyr Gly Ala Ile Arg Trp Thr
Gly Asp Phe Ser Glu Arg Ser His 130 135 140 Ser Ala Ser Thr Arg Phe
Trp Lys Lys Val Arg Tyr His Met Pro Ser 145 150 155 160 Arg Lys His
Gly Ser Ser Ser Gly Phe 165 <210> SEQ ID NO 82 <211>
LENGTH: 140 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 82 His Met Pro Glu Arg Phe Asp Ala
Phe Ile Cys Tyr Cys Pro Ser Asp 1 5 10 15 Ile Gln Phe Val Gln Glu
Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr 20 25 30 Arg Leu Lys Leu
Cys Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys 35 40 45 Val Trp
Ser Ile Ala Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met 50 55 60
Val Val Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe 65
70 75 80 Gln Thr Lys Phe Ala Leu Ser Leu Ser Pro Gly Ala His Gln
Lys Leu 85 90 95 Ile Pro Ile Lys Tyr Lys Ala Met Lys Lys Glu Phe
Pro Ser Ile Leu 100 105 110 Arg Phe Ile Thr Val Cys Asp Tyr Thr Asn
Pro Cys Thr Lys Ser Trp 115 120 125 Phe Trp Thr Arg Leu Ala Lys Ala
Leu Ser Leu Pro 130 135 140 <210> SEQ ID NO 83 <211>
LENGTH: 140 <212> TYPE: PRT <213> ORGANISM: Mus
musculus <400> SEQUENCE: 83 Gln Thr Pro Glu Leu Phe Asp Ala
Phe Ile Cys Tyr Cys Pro Asn Asp 1 5 10 15 Ile Glu Phe Val Gln Glu
Met Ile Arg Gln Leu Glu Gln Thr Asp Tyr 20 25 30 Arg Leu Lys Leu
Cys Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys 35 40 45 Val Trp
Ser Ile Ala Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met 50 55 60
Val Val Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe 65
70 75 80 Gln Thr Lys Phe Ala Leu Ser Leu Ser Pro Gly Val Gln Gln
Lys Leu 85 90 95 Ile Pro Ile Lys Tyr Lys Ala Met Lys Lys Asp Phe
Pro Ser Ile Leu 100 105 110 Arg Phe Ile Thr Ile Cys Asp Tyr Thr Asn
Pro Cys Thr Lys Ser Trp 115 120 125 Phe Trp Thr Arg Leu Ala Lys Ala
Leu Ser Leu Pro 130 135 140 <210> SEQ ID NO 84 <211>
LENGTH: 154 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 84 Gln Arg Asn Leu Gln Phe His Ala
Phe Ile Ser Tyr Ser Gly His Asp 1 5 10 15 Ser Phe Trp Val Lys Asn
Glu Leu Leu Pro Asn Leu Glu Lys Glu Gly 20 25 30 Met Gln Ile Cys
Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile 35 40 45 Val Glu
Asn Ile Ile Thr Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe 50 55 60
Val Leu Ser Pro Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu 65
70 75 80 Tyr Phe Ala His His Asn Leu Phe His Glu Gly Ser Ser Leu
Ile Leu 85 90 95 Ile Leu Leu Glu Pro Ile Pro Gln Tyr Ser Ile Pro
Ser Ser Tyr His 100 105 110 Lys Leu Lys Ser Leu Met Ala Arg Arg Thr
Tyr Leu Glu Trp Pro Lys 115 120 125 Glu Lys Ser Lys Arg Gly Leu Phe
Trp Ala Asn Leu Arg Ala Ala Ile 130 135 140 Asn Ile Lys Leu Thr Glu
Gln Ala Lys Lys 145 150 <210> SEQ ID NO 85 <211>
LENGTH: 148 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 85 Ser Arg Asn Ile Cys Tyr Asp Ala
Phe Val Ser Tyr Ser Glu Arg Asp 1 5 10 15 Ala Tyr Trp Val Glu Asn
Leu Met Val Gln Glu Leu Glu Asn Phe Asn 20 25 30 Pro Pro Phe Lys
Leu Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys 35 40 45 Trp Ile
Ile Asp Asn Ile Ile Asp Ser Ile Glu Lys Thr Thr Lys Leu 50 55 60
Ser Phe Val Leu Ser Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr 65
70 75 80 Glu Leu Asp Phe Ser His Phe Arg Leu Phe Asp Glu Asn Asn
Ala Ala 85 90 95 Ile Leu Ile Leu Leu Glu Pro Ile Glu Lys Lys Ala
Ile Pro Gln Arg 100 105 110 Phe Cys Lys Leu Arg Lys Ile Met Asn Thr
Lys Thr Tyr Leu Glu Trp 115 120 125 Pro Met Asp Glu Ala Gln Arg Glu
Gly Phe Trp Val Asn Leu Arg Ala 130 135 140 Ala Ile Lys Ser 145
<210> SEQ ID NO 86 <211> LENGTH: 154 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 86 Thr
Glu Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr Lys Asp 1 5 10
15 Lys Asp Trp Val Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln
20 25 30 Ser Leu Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly
Val Phe 35 40 45 Glu Leu Glu Ala Ile Val Asn Ser Ile Lys Arg Ser
Arg Lys Ile Ile 50 55 60 Phe Val Ile Thr His His Leu Leu Lys Asp
Pro Leu Cys Lys Arg Phe 65 70 75 80 Lys Val His His Ala Val Gln Gln
Ala Ile Glu Gln Asn Leu Ser Ile 85 90 95 Ile Leu Val Phe Leu Glu
Glu Ile Pro Asp Tyr Lys Leu Asn His Ala 100 105 110 Leu Cys Leu Arg
Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp 115 120 125 Pro Val
Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val 130 135 140
Ala Leu Gly Ile Gln Lys Leu Cys Tyr Ile 145 150 <210> SEQ ID
NO 87 <211> LENGTH: 159 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 87 Arg Gly Glu Asn Ile
Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp 1 5 10 15 Glu Asp Trp
Val Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val 20 25 30 Pro
Pro Phe Gln Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val 35 40
45 Ala Ile Ala Ala Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys
50 55 60 Val Ile Val Val Val Ser Gln His Phe Ile Gln Ser Arg Trp
Cys Ile 65 70 75 80 Phe Glu Tyr Glu Ile Ala Gln Thr Trp Gln Phe Leu
Ser Ser Arg Ala 85 90 95 Gly Ile Ile Phe Ile Val Leu Gln Lys Val
Glu Lys Thr Leu Leu Arg 100 105 110 Gln Gln Val Glu Leu Tyr Arg Leu
Leu Ser Arg Asn Thr Tyr Leu Leu 115 120 125 Glu Trp Glu Asp Ser Val
Leu Gly Arg His Ile Phe Trp Arg Arg Leu 130 135 140 Arg Lys Ala Leu
Leu Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr 145 150 155 <210>
SEQ ID NO 88 <211> LENGTH: 160 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 88 Pro Asp
Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp 1 5 10 15
Phe Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr 20
25 30 Ser Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe
Val 35 40 45 Pro Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile
Trp Asn Ser 50 55 60 Arg Lys Ile Val Cys Leu Val Ser Arg His Phe
Leu Arg Asp Gly Trp 65 70 75 80 Cys Leu Glu Ala Phe Ser Tyr Ala Gln
Gly Arg Cys Leu Ser Asp Leu 85 90 95 Asn Ser Ala Leu Ile Met Val
Val Val Gly Ser Leu Ser Gln Tyr Gln 100 105 110 Leu Met Lys His Gln
Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr 115 120 125 Leu Arg Trp
Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys 130 135 140 Ser
Gln Gln Ile Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn Ile 145 150
155 160 <210> SEQ ID NO 89 <211> LENGTH: 150
<212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster
<400> SEQUENCE: 89 Asp Ala Gly Lys Leu Tyr Asp Ala Ile Ile
Leu His Ser Glu Lys Asp 1 5 10 15 Tyr Glu Phe Val Cys Arg Asn Ile
Ala Ala Glu Leu Glu His Gly Arg 20 25 30 Pro Pro Phe Arg Leu Cys
Ile Gln Gln Arg Asp Leu Pro Pro Ala Ser 35 40 45 His Leu Gln Leu
Val Glu Gly Ala Arg Ala Ser Arg Lys Ile Ile Leu 50 55 60 Val Leu
Thr Arg Asn Leu Leu Ala Thr Glu Trp Asn Arg Ile Glu Phe 65 70 75 80
Arg Asn Ala Phe His Glu Ser Leu Arg Gly Leu Ala Lys Leu Val Ile 85
90 95 Ile Glu Glu Thr Ser Val Ser Ala Glu Ala Glu Asp Val Ala Glu
Leu 100 105 110 Ser Pro Tyr Leu Lys Ser Val Pro Ser Asn Arg Leu Leu
Thr Cys Asp 115 120 125 Arg Tyr Phe Trp Glu Lys Leu Arg Tyr Ala Ile
Pro Ile Glu Leu Ser 130 135 140 Pro Arg Gly Asn Asn Tyr 145 150
<210> SEQ ID NO 90 <211> LENGTH: 144 <212> TYPE:
PRT <213> ORGANISM: Drosophila melanogaster <400>
SEQUENCE: 90 Asp Lys Asp Lys Arg Phe Asp Ala Phe Leu Ala Phe Thr
His Lys Asp 1 5 10 15 Glu Ala Leu Leu Glu Glu Phe Val Asp Arg Leu
Glu Arg Gly Arg Pro 20 25 30 Arg Phe Gln Leu Cys Phe Tyr Leu Arg
Asp Trp Leu Ala Gly Glu Ser 35 40 45 Ile Pro Asp Cys Ile Gly Gln
Ser Ile Lys Asp Ser Arg Arg Ile Ile 50 55 60 Val Leu Met Thr Glu
Asn Phe Met Asn Ser Thr Trp Gly Arg Leu Glu 65 70 75 80 Phe Arg Leu
Ala Leu His Ala Thr Ser Arg Asp Arg Cys Arg Leu Ile 85 90 95 Val
Val Leu Tyr Pro Asn Val Lys Asn Phe Asp Ser Leu Asp Ser Glu 100 105
110 Leu Arg Thr Tyr Met Ala Phe Asn Thr Tyr Leu Glu Arg Ser His Pro
115 120 125 Asn Phe Trp Asn Lys Leu Ile Tyr Ser Met Pro His Thr Lys
Leu Arg 130 135 140 <210> SEQ ID NO 91 <211> LENGTH:
150 <212> TYPE: PRT <213> ORGANISM: Drosophila
melanogaster <400> SEQUENCE: 91 Asp Lys Asp Lys Lys Phe Asp
Ala Phe Ile Ser Tyr Ser His Lys Asp 1 5 10 15 Gln Ser Phe Ile Glu
Asp Tyr Leu Val Pro Gln Leu Glu His Gly Pro 20 25 30 Gln Lys Phe
Gln Leu Cys Val His Glu Arg Asp Trp Leu Val Gly Gly 35 40 45 His
Ile Pro Glu Asn Ile Met Arg Ser Val Ala Asp Ser Arg Arg Thr 50 55
60 Ile Ile Val Leu Ser Gln Asn Phe Ile Lys Ser Glu Trp Ala Arg Leu
65 70 75 80 Glu Phe Arg Ala Ala His Arg Ser Ala Leu Asn Glu Gly Arg
Arg Ile 85 90 95 Ile Val Ile Ile Tyr Ser Asp Ile Gly Asp Val Glu
Lys Leu Asp Glu 100 105 110 Glu Leu Lys Ala Tyr Leu Lys Met Asn Thr
Tyr Leu Lys Trp Gly Asp 115 120 125 Pro Trp Phe Trp Asp Lys Leu Arg
Phe Ala Leu Pro His Arg Arg Pro 130 135 140 Val Gly Asn Ile Gly Asn
145 150 <210> SEQ ID NO 92 <211> LENGTH: 153
<212> TYPE: PRT <213> ORGANISM: Nicotiana tabacum
<400> SEQUENCE: 92 Ser Ser Arg Trp Ser Tyr Asp Val Phe Leu
Ser Phe Arg Gly Glu Asp 1 5 10 15 Thr Arg Lys Thr Phe Thr Ser His
Leu Tyr Glu Val Leu Asn Asp Lys 20 25 30 Gly Ile Lys Thr Phe Gln
Asp Asp Lys Arg Leu Glu Tyr Gly Ala Thr 35 40 45 Ile Pro Gly Glu
Leu Cys Lys Ala Ile Glu Glu Ser Gln Phe Ala Ile 50 55 60 Val Val
Phe Ser Glu Asn Tyr Ala Thr Ser Arg Trp Cys Leu Asn Glu 65 70 75 80
Leu Val Lys Ile Met Glu Cys Lys Thr Arg Phe Lys Gln Thr Val Ile 85
90 95 Pro Ile Phe Tyr Asp Val Asp Pro Ser His Val Arg Asn Gln Lys
Glu 100 105 110 Ser Phe Ala Lys Ala Phe Glu Glu His Glu Thr Lys Tyr
Lys Asp Asp 115 120 125 Val Glu Gly Ile Gln Arg Trp Arg Ile Ala Leu
Asn Glu Ala Ala Asn 130 135 140 Leu Lys Gly Ser Cys Asp Asn Arg Asp
145 150 <210> SEQ ID NO 93 <211> LENGTH: 151
<212> TYPE: PRT <213> ORGANISM: Linum usitatissimum
<400> SEQUENCE: 93 Phe Pro Ser Val Glu Tyr Glu Val Phe Leu
Ser Phe Arg Gly Pro Asp 1 5 10 15 Thr Arg Glu Gln Phe Thr Asp Phe
Leu Tyr Gln Ser Leu Arg Arg Tyr 20 25 30 Lys Ile His Thr Phe Arg
Asp Asp Asp Glu Leu Leu Lys Gly Lys Glu 35 40 45 Ile Gly Pro Asn
Leu Leu Arg Ala Ile Asp Gln Ser Lys Ile Tyr Val 50 55 60 Pro Ile
Ile Ser Ser Gly Tyr Ala Asp Ser Lys Trp Cys Leu Met Glu 65 70 75 80
Leu Ala Glu Ile Val Arg Arg Gln Glu Glu Asp Pro Arg Ile Ile Leu 85
90 95 Pro Ile Phe Tyr Met Val Asp Pro Ser Asp Val Arg His Gln Thr
Gly 100 105 110 Cys Tyr Lys Lys Ala Phe Arg Lys His Ala Asn Lys Phe
Asp Gly Gln 115 120 125 Thr Ile Gln Asn Trp Lys Asp Ala Leu Lys Lys
Val Gly Asp Leu Lys 130 135 140 Gly Trp His Ile Gly Lys Asn 145 150
<210> SEQ ID NO 94 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic 6xHis tag <400> SEQUENCE: 94 His His His His His
His 1 5
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 94 <210>
SEQ ID NO 1 <211> LENGTH: 2367 <212> TYPE: DNA
<213> ORGANISM: Homo sapiens <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(2358) <220>
FEATURE: <221> NAME/KEY: mat_peptide <222> LOCATION:
(67)..(2358) <400> SEQUENCE: 1 atg act agc atc ttc cat ttt
gcc att atc ttc atg tta ata ctt cag 48 Met Thr Ser Ile Phe His Phe
Ala Ile Ile Phe Met Leu Ile Leu Gln -20 -15 -10 atc aga ata caa tta
tct gaa gaa agt gaa ttt tta gtt gat agg tca 96 Ile Arg Ile Gln Leu
Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser -5 -1 1 5 10 aaa aac
ggt ctc atc cac gtt cct aaa gac cta tcc cag aaa aca aca 144 Lys Asn
Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 15 20 25
atc tta aat ata tcg caa aat tat ata tct gag ctt tgg act tct gac 192
Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 30
35 40 atc tta tca ctg tca aaa ctg agg att ttg ata att tct cat aat
aga 240 Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn
Arg 45 50 55 atc cag tat ctt gat atc agt gtt ttc aaa ttc aac cag
gaa ttg gaa 288 Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln
Glu Leu Glu 60 65 70 tac ttg gat ttg tcc cac aac aag ttg gtg aag
att tct tgc cac cct 336 Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys
Ile Ser Cys His Pro 75 80 85 90 act gtg aac ctc aag cac ttg gac ctg
tca ttt aat gca ttt gat gcc 384 Thr Val Asn Leu Lys His Leu Asp Leu
Ser Phe Asn Ala Phe Asp Ala 95 100 105 ctg cct ata tgc aaa gag ttt
ggc aat atg tct caa cta aaa ttt ctg 432 Leu Pro Ile Cys Lys Glu Phe
Gly Asn Met Ser Gln Leu Lys Phe Leu 110 115 120 ggg ttg agc acc aca
cac tta gaa aaa tct agt gtg ctg cca att gct 480 Gly Leu Ser Thr Thr
His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 125 130 135 cat ttg aat
atc agc aag gtc ttg ctg gtc tta gga gag act tat ggg 528 His Leu Asn
Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 140 145 150 gaa
aaa gaa gac cct gag ggc ctt caa gac ttt aac act gag agt ctg 576 Glu
Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 155 160
165 170 cac att gtg ttc ccc aca aac aaa gaa ttc cat ttt att ttg gat
gtg 624 His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp
Val 175 180 185 tca gtc aag act gta gca aat ctg gaa cta tct aat atc
aaa tgt gtg 672 Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile
Lys Cys Val 190 195 200 cta gaa gat aac aaa tgt tct tac ttc cta agt
att ctg gcg aaa ctt 720 Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser
Ile Leu Ala Lys Leu 205 210 215 caa aca aat cca aag tta tca agt ctt
acc tta aac aac att gaa aca 768 Gln Thr Asn Pro Lys Leu Ser Ser Leu
Thr Leu Asn Asn Ile Glu Thr 220 225 230 act tgg aat tct ttc att agg
atc ctc caa cta gtt tgg cat aca act 816 Thr Trp Asn Ser Phe Ile Arg
Ile Leu Gln Leu Val Trp His Thr Thr 235 240 245 250 gta tgg tat ttc
tca att tca aac gtg aag cta cag ggt cag ctg gac 864 Val Trp Tyr Phe
Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 255 260 265 ttc aga
gat ttt gat tat tct ggc act tcc ttg aag gcc ttg tct ata 912 Phe Arg
Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 270 275 280
cac caa gtt gtc agc gat gtg ttc ggt ttt ccg caa agt tat atc tat 960
His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 285
290 295 gaa atc ttt tcg aat atg aac atc aaa aat ttc aca gtg tct ggt
aca 1008 Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser
Gly Thr 300 305 310 cgc atg gtc cac atg ctt tgc cca tcc aaa att agc
ccg ttc ctg cat 1056 Arg Met Val His Met Leu Cys Pro Ser Lys Ile
Ser Pro Phe Leu His 315 320 325 330 ttg gat ttt tcc aat aat ctc tta
aca gac acg gtt ttt gaa aat tgt 1104 Leu Asp Phe Ser Asn Asn Leu
Leu Thr Asp Thr Val Phe Glu Asn Cys 335 340 345 ggg cac ctt act gag
ttg gag aca ctt att tta caa atg aat caa tta 1152 Gly His Leu Thr
Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 350 355 360 aaa gaa
ctt tca aaa ata gct gaa atg act aca cag atg aag tct ctg 1200 Lys
Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 365 370
375 caa caa ttg gat att agc cag aat tct gta agc tat gat gaa aag aaa
1248 Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys
Lys 380 385 390 gga gac tgt tct tgg act aaa agt tta tta agt tta aat
atg tct tca 1296 Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu
Asn Met Ser Ser 395 400 405 410 aat ata ctt act gac act att ttc aga
tgt tta cct ccc agg atc aag 1344 Asn Ile Leu Thr Asp Thr Ile Phe
Arg Cys Leu Pro Pro Arg Ile Lys 415 420 425 gta ctt gat ctt cac agc
aat aaa ata aag agc att cct aaa caa gtc 1392 Val Leu Asp Leu His
Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 430 435 440 gta aaa ctg
gaa gct ttg caa gaa ctc aat gtt gct ttc aat tct tta 1440 Val Lys
Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 445 450 455
act gac ctt cct gga tgt ggc agc ttt agc agc ctt tct gta ttg atc
1488 Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu
Ile 460 465 470 att gat cac aat tca gtt tcc cac cca tca gct gat ttc
ttc cag agc 1536 Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp
Phe Phe Gln Ser 475 480 485 490 tgc cag aag atg agg tca ata aaa gca
ggg gac aat cca ttc caa tgt 1584 Cys Gln Lys Met Arg Ser Ile Lys
Ala Gly Asp Asn Pro Phe Gln Cys 495 500 505 acc tgt gag ctc gga gaa
ttt gtc aaa aat ata gac caa gta tca agt 1632 Thr Cys Glu Leu Gly
Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 510 515 520 gaa gtg tta
gag ggc tgg cct gat tct tat aag tgt gac tac ccg gaa 1680 Glu Val
Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 525 530 535
agt tat aga gga acc cta cta aag gac ttt cac atg tct gaa tta tcc
1728 Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu
Ser 540 545 550 tgc aac ata act ctg ctg atc gtc acc atc gtt gcc acc
atg ctg gtg 1776 Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala
Thr Met Leu Val 555 560 565 570 ttg gct gtg act gtg acc tcc ctc tgc
atc tac ttg gat ctg ccc tgg 1824 Leu Ala Val Thr Val Thr Ser Leu
Cys Ile Tyr Leu Asp Leu Pro Trp 575 580 585 tat ctc agg atg gtg tgc
cag tgg acc cag acc cgg cgc agg gcc agg 1872 Tyr Leu Arg Met Val
Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 590 595 600 aac ata ccc
tta gaa gaa ctc caa aga aat ctc cag ttt cat gca ttt 1920 Asn Ile
Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 605 610 615
att tca tat agt ggg cac gat tct ttc tgg gtg aag aat gaa tta ttg
1968 Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu
Leu 620 625 630 cca aac cta gag aaa gaa ggt atg cag att tgc ctt cat
gag aga aac 2016 Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu
His Glu Arg Asn 635 640 645 650 ttt gtt cct ggc aag agc att gtg gaa
aat atc atc acc tgc att gag 2064 Phe Val Pro Gly Lys Ser Ile Val
Glu Asn Ile Ile Thr Cys Ile Glu 655 660 665 aag agt tac aag tcc atc
ttt gtt ttg tct ccc aac ttt gtc cag agt 2112 Lys Ser Tyr Lys Ser
Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 670 675 680 gaa tgg tgc
cat tat gaa ctc tac ttt gcc cat cac aat ctc ttt cat 2160 Glu Trp
Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 685 690 695
gaa gga tct aat agc tta atc ctg atc ttg ctg gaa ccc att ccg cag
2208 Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro
Gln 700 705 710 tac tcc att cct agc agt tat cac aag ctc aaa agt ctc
atg gcc agg 2256 Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser
Leu Met Ala Arg 715 720 725 730 agg act tat ttg gaa tgg ccc aag gaa
aag agc aaa cgt ggc ctt ttt 2304 Arg Thr Tyr Leu Glu Trp Pro Lys
Glu Lys Ser Lys Arg Gly Leu Phe 735 740 745 tgg gct aac tta agg gca
gcc att aat att aag ctg aca gag caa gca 2352 Trp Ala Asn Leu Arg
Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 750 755 760 aag aaa
tagtctaga 2367 Lys Lys <210> SEQ ID NO 2 <211> LENGTH:
786 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 2 Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe
Met Leu Ile Leu Gln -20 -15 -10 Ile Arg Ile Gln Leu Ser Glu Glu Ser
Glu Phe Leu Val Asp Arg Ser -5 -1 1 5 10 Lys Asn Gly Leu Ile His
Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 15 20 25 Ile Leu Asn Ile
Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 30 35 40 Ile Leu
Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 45 50 55
Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 60
65 70 Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His
Pro 75 80 85 90 Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala
Phe Asp Ala 95 100 105
Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 110
115 120 Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile
Ala 125 130 135 His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu
Thr Tyr Gly 140 145 150 Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe
Asn Thr Glu Ser Leu 155 160 165 170 His Ile Val Phe Pro Thr Asn Lys
Glu Phe His Phe Ile Leu Asp Val 175 180 185 Ser Val Lys Thr Val Ala
Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 190 195 200 Leu Glu Asp Asn
Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 205 210 215 Gln Thr
Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 220 225 230
Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 235
240 245 250 Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln
Leu Asp 255 260 265 Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys
Ala Leu Ser Ile 270 275 280 His Gln Val Val Ser Asp Val Phe Gly Phe
Pro Gln Ser Tyr Ile Tyr 285 290 295 Glu Ile Phe Ser Asn Met Asn Ile
Lys Asn Phe Thr Val Ser Gly Thr 300 305 310 Arg Met Val His Met Leu
Cys Pro Ser Lys Ile Ser Pro Phe Leu His 315 320 325 330 Leu Asp Phe
Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 335 340 345 Gly
His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 350 355
360 Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu
365 370 375 Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu
Lys Lys 380 385 390 Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu
Asn Met Ser Ser 395 400 405 410 Asn Ile Leu Thr Asp Thr Ile Phe Arg
Cys Leu Pro Pro Arg Ile Lys 415 420 425 Val Leu Asp Leu His Ser Asn
Lys Ile Lys Ser Ile Pro Lys Gln Val 430 435 440 Val Lys Leu Glu Ala
Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 445 450 455 Thr Asp Leu
Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 460 465 470 Ile
Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 475 480
485 490 Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln
Cys 495 500 505 Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln
Val Ser Ser 510 515 520 Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys
Cys Asp Tyr Pro Glu 525 530 535 Ser Tyr Arg Gly Thr Leu Leu Lys Asp
Phe His Met Ser Glu Leu Ser 540 545 550 Cys Asn Ile Thr Leu Leu Ile
Val Thr Ile Val Ala Thr Met Leu Val 555 560 565 570 Leu Ala Val Thr
Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 575 580 585 Tyr Leu
Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 590 595 600
Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 605
610 615 Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu
Leu 620 625 630 Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His
Glu Arg Asn 635 640 645 650 Phe Val Pro Gly Lys Ser Ile Val Glu Asn
Ile Ile Thr Cys Ile Glu 655 660 665 Lys Ser Tyr Lys Ser Ile Phe Val
Leu Ser Pro Asn Phe Val Gln Ser 670 675 680 Glu Trp Cys His Tyr Glu
Leu Tyr Phe Ala His His Asn Leu Phe His 685 690 695 Glu Gly Ser Asn
Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 700 705 710 Tyr Ser
Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 715 720 725
730 Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe
735 740 745 Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu
Gln Ala 750 755 760 Lys Lys <210> SEQ ID NO 3 <211>
LENGTH: 2355 <212> TYPE: DNA <213> ORGANISM: Homo
sapiens <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(2352) <220> FEATURE: <221> NAME/KEY:
mat_peptide <222> LOCATION: (67)..(2352) <400>
SEQUENCE: 3 atg cca cat act ttg tgg atg gtg tgg gtc ttg ggg gtc atc
atc agc 48 Met Pro His Thr Leu Trp Met Val Trp Val Leu Gly Val Ile
Ile Ser -20 -15 -10 ctc tcc aag gaa gaa tcc tcc aat cag gct tct ctg
tct tgt gac cgc 96 Leu Ser Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu
Ser Cys Asp Arg -5 -1 1 5 10 aat ggt atc tgc aag ggc agc tca gga
tct tta aac tcc att ccc tca 144 Asn Gly Ile Cys Lys Gly Ser Ser Gly
Ser Leu Asn Ser Ile Pro Ser 15 20 25 ggg ctc aca gaa gct gta aaa
agc ctt gac ctg tcc aac aac agg atc 192 Gly Leu Thr Glu Ala Val Lys
Ser Leu Asp Leu Ser Asn Asn Arg Ile 30 35 40 acc tac att agc aac
agt gac cta cag agg tgt gtg aac ctc cag gct 240 Thr Tyr Ile Ser Asn
Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala 45 50 55 ctg gtg ctg
aca tcc aat gga att aac aca ata gag gaa gat tct ttt 288 Leu Val Leu
Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe 60 65 70 tct
tcc ctg ggc agt ctt gaa cat tta gac tta tcc tat aat tac tta 336 Ser
Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr Leu 75 80
85 90 tct aat tta tcg tct tcc tgg ttc aag ccc ctt tct tct tta aca
ttc 384 Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser Leu Thr
Phe 95 100 105 tta aac tta ctg gga aat cct tac aaa acc cta ggg gaa
aca tct ctt 432 Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu Gly Glu
Thr Ser Leu 110 115 120 ttt tct cat ctc aca aaa ttg caa atc ctg aga
gtg gga aat atg gac 480 Phe Ser His Leu Thr Lys Leu Gln Ile Leu Arg
Val Gly Asn Met Asp 125 130 135 acc ttc act aag att caa aga aaa gat
ttt gct gga ctt acc ttc ctt 528 Thr Phe Thr Lys Ile Gln Arg Lys Asp
Phe Ala Gly Leu Thr Phe Leu 140 145 150 gag gaa ctt gag att gat gct
tca gat cta cag agc tat gag cca aaa 576 Glu Glu Leu Glu Ile Asp Ala
Ser Asp Leu Gln Ser Tyr Glu Pro Lys 155 160 165 170 agt ttg aag tca
att cag aac gta agt cat ctg atc ctt cat atg aag 624 Ser Leu Lys Ser
Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys 175 180 185 cag cat
att tta ctg ctg gag att ttt gta gat gtt aca agt tcc gtg 672 Gln His
Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val 190 195 200
gaa tgt ttg gaa ctg cga gat act gat ttg gac act ttc cat ttt tca 720
Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe Ser 205
210 215 gaa cta tcc act ggt gaa aca aat tca ttg att aaa aag ttt aca
ttt 768 Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys Phe Thr
Phe 220 225 230 aga aat gtg aaa atc acc gat gaa agt ttg ttt cag gtt
atg aaa ctt 816 Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe Gln Val
Met Lys Leu 235 240 245 250 ttg aat cag att tct gga ttg tta gaa tta
gag ttt gat gac tgt acc 864 Leu Asn Gln Ile Ser Gly Leu Leu Glu Leu
Glu Phe Asp Asp Cys Thr 255 260 265 ctt aat gga gtt ggt aat ttt aga
gca tct gat aat gac aga gtt ata 912 Leu Asn Gly Val Gly Asn Phe Arg
Ala Ser Asp Asn Asp Arg Val Ile 270 275 280 gat cca ggt aaa gtg gaa
acg tta aca atc cgg agg ctg cat att cca 960 Asp Pro Gly Lys Val Glu
Thr Leu Thr Ile Arg Arg Leu His Ile Pro 285 290 295 agg ttt tac tta
ttt tat gat ctg agc act tta tat tca ctt aca gaa 1008 Arg Phe Tyr
Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu 300 305 310 aga
gtt aaa aga atc aca gta gaa aac agt aaa gtt ttt ctg gtt cct 1056
Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 315
320 325 330 tgt tta ctt tca caa cat tta aaa tca tta gaa tac ttg gat
ctc agt 1104 Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu
Asp Leu Ser 335 340 345 gaa aat ttg atg gtt gaa gaa tac ttg aaa aat
tca gcc tgt gag gat 1152 Glu Asn Leu Met Val Glu Glu Tyr Leu Lys
Asn Ser Ala Cys Glu Asp 350 355 360 gcc tgg ccc tct cta caa act tta
att tta agg caa aat cat ttg gca 1200 Ala Trp Pro Ser Leu Gln Thr
Leu Ile Leu Arg Gln Asn His Leu Ala 365 370 375 tca ttg gaa aaa acc
gga gag act ttg ctc act ctg aaa aac ttg act 1248 Ser Leu Glu Lys
Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr 380 385 390 aac att
gat atc agt aag aat agt ttt cat tct atg cct gaa act tgt 1296 Asn
Ile Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys 395 400
405 410 cag tgg cca gaa aag atg aaa tat ttg aac tta tcc agc aca cga
ata 1344 Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr
Arg Ile 415 420 425 cac agt gta aca ggc tgc att ccc aag aca ctg gaa
att tta gat gtt 1392
His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu Asp Val 430
435 440 agc aac aac aat ctc aat tta ttt tct ttg aat ttg ccg caa ctc
aaa 1440 Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu Pro Gln
Leu Lys 445 450 455 gaa ctt tat att tcc aga aat aag ttg atg act cta
cca gat gcc tcc 1488 Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met Thr
Leu Pro Asp Ala Ser 460 465 470 ctc tta ccc atg tta cta gta ttg aaa
atc agt agg aat gca ata act 1536 Leu Leu Pro Met Leu Leu Val Leu
Lys Ile Ser Arg Asn Ala Ile Thr 475 480 485 490 acg ttt tct aag gag
caa ctt gac tca ttt cac aca ctg aag act ttg 1584 Thr Phe Ser Lys
Glu Gln Leu Asp Ser Phe His Thr Leu Lys Thr Leu 495 500 505 gaa gct
ggt ggc aat aac ttc att tgc tcc tgt gaa ttc ctc tcc ttc 1632 Glu
Ala Gly Gly Asn Asn Phe Ile Cys Ser Cys Glu Phe Leu Ser Phe 510 515
520 act cag gag cag caa gca ctg gcc aaa gtc ttg att gat tgg cca gca
1680 Thr Gln Glu Gln Gln Ala Leu Ala Lys Val Leu Ile Asp Trp Pro
Ala 525 530 535 aat tac ctg tgt gac tct cca tcc cat gtg cgt ggc cag
cag gtt cag 1728 Asn Tyr Leu Cys Asp Ser Pro Ser His Val Arg Gly
Gln Gln Val Gln 540 545 550 gat gtc cgc ctc tcg gtg tcg gaa tgt cac
agg aca gca ctg gtg tct 1776 Asp Val Arg Leu Ser Val Ser Glu Cys
His Arg Thr Ala Leu Val Ser 555 560 565 570 ggc atg tgc tgt gct ctg
ttc ctg ctg atc ctg ctc acg ggg gtc ctg 1824 Gly Met Cys Cys Ala
Leu Phe Leu Leu Ile Leu Leu Thr Gly Val Leu 575 580 585 tgc cac cgt
ttc cat ggc ctg tgg tat atg aaa atg atg tgg gcc tgg 1872 Cys His
Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp 590 595 600
ctc cag gcc aaa agg aag ccc agg aaa gct ccc agc agg aac atc tgc
1920 Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile
Cys 605 610 615 tat gat gca ttt gtt tct tac agt gag cgg gat gcc tac
tgg gtg gag 1968 Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala
Tyr Trp Val Glu 620 625 630 aac ctt atg gtc cag gag ctg gag aac ttc
aat ccc ccc ttc aag ttg 2016 Asn Leu Met Val Gln Glu Leu Glu Asn
Phe Asn Pro Pro Phe Lys Leu 635 640 645 650 tgt ctt cat aag cgg gac
ttc att cct ggc aag tgg atc att gac aat 2064 Cys Leu His Lys Arg
Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn 655 660 665 atc att gac
tcc att gaa aag agc cac aaa act gtc ttt gtg ctt tct 2112 Ile Ile
Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser 670 675 680
gaa aac ttt gtg aag agt gag tgg tgc aag tat gaa ctg gac ttc tcc
2160 Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe
Ser 685 690 695 cat ttc cgt ctt ttt gaa gag aac aat gat gct gcc att
ctc att ctt 2208 His Phe Arg Leu Phe Glu Glu Asn Asn Asp Ala Ala
Ile Leu Ile Leu 700 705 710 ctg gag ccc att gag aaa aaa gcc att ccc
cag cgc ttc tgc aag ctg 2256 Leu Glu Pro Ile Glu Lys Lys Ala Ile
Pro Gln Arg Phe Cys Lys Leu 715 720 725 730 cgg aag ata atg aac acc
aag acc tac ctg gag tgg ccc atg gac gag 2304 Arg Lys Ile Met Asn
Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu 735 740 745 gct cag cgg
gaa gga ttt tgg gta aat ctg aga gct gcg ata aag tcc 2352 Ala Gln
Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 750 755 760
tag 2355 <210> SEQ ID NO 4 <211> LENGTH: 784
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 4 Met Pro His Thr Leu Trp Met Val Trp Val Leu
Gly Val Ile Ile Ser -20 -15 -10 Leu Ser Lys Glu Glu Ser Ser Asn Gln
Ala Ser Leu Ser Cys Asp Arg -5 -1 1 5 10 Asn Gly Ile Cys Lys Gly
Ser Ser Gly Ser Leu Asn Ser Ile Pro Ser 15 20 25 Gly Leu Thr Glu
Ala Val Lys Ser Leu Asp Leu Ser Asn Asn Arg Ile 30 35 40 Thr Tyr
Ile Ser Asn Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala 45 50 55
Leu Val Leu Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe 60
65 70 Ser Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr
Leu 75 80 85 90 Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser
Leu Thr Phe 95 100 105 Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu
Gly Glu Thr Ser Leu 110 115 120 Phe Ser His Leu Thr Lys Leu Gln Ile
Leu Arg Val Gly Asn Met Asp 125 130 135 Thr Phe Thr Lys Ile Gln Arg
Lys Asp Phe Ala Gly Leu Thr Phe Leu 140 145 150 Glu Glu Leu Glu Ile
Asp Ala Ser Asp Leu Gln Ser Tyr Glu Pro Lys 155 160 165 170 Ser Leu
Lys Ser Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys 175 180 185
Gln His Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val 190
195 200 Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe
Ser 205 210 215 Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys
Phe Thr Phe 220 225 230 Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe
Gln Val Met Lys Leu 235 240 245 250 Leu Asn Gln Ile Ser Gly Leu Leu
Glu Leu Glu Phe Asp Asp Cys Thr 255 260 265 Leu Asn Gly Val Gly Asn
Phe Arg Ala Ser Asp Asn Asp Arg Val Ile 270 275 280 Asp Pro Gly Lys
Val Glu Thr Leu Thr Ile Arg Arg Leu His Ile Pro 285 290 295 Arg Phe
Tyr Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu 300 305 310
Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 315
320 325 330 Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu Asp
Leu Ser 335 340 345 Glu Asn Leu Met Val Glu Glu Tyr Leu Lys Asn Ser
Ala Cys Glu Asp 350 355 360 Ala Trp Pro Ser Leu Gln Thr Leu Ile Leu
Arg Gln Asn His Leu Ala 365 370 375 Ser Leu Glu Lys Thr Gly Glu Thr
Leu Leu Thr Leu Lys Asn Leu Thr 380 385 390 Asn Ile Asp Ile Ser Lys
Asn Ser Phe His Ser Met Pro Glu Thr Cys 395 400 405 410 Gln Trp Pro
Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile 415 420 425 His
Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu Asp Val 430 435
440 Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu Pro Gln Leu Lys
445 450 455 Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met Thr Leu Pro Asp
Ala Ser 460 465 470 Leu Leu Pro Met Leu Leu Val Leu Lys Ile Ser Arg
Asn Ala Ile Thr 475 480 485 490 Thr Phe Ser Lys Glu Gln Leu Asp Ser
Phe His Thr Leu Lys Thr Leu 495 500 505 Glu Ala Gly Gly Asn Asn Phe
Ile Cys Ser Cys Glu Phe Leu Ser Phe 510 515 520 Thr Gln Glu Gln Gln
Ala Leu Ala Lys Val Leu Ile Asp Trp Pro Ala 525 530 535 Asn Tyr Leu
Cys Asp Ser Pro Ser His Val Arg Gly Gln Gln Val Gln 540 545 550 Asp
Val Arg Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu Val Ser 555 560
565 570 Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu Thr Gly Val
Leu 575 580 585 Cys His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met
Trp Ala Trp 590 595 600 Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro
Ser Arg Asn Ile Cys 605 610 615 Tyr Asp Ala Phe Val Ser Tyr Ser Glu
Arg Asp Ala Tyr Trp Val Glu 620 625 630 Asn Leu Met Val Gln Glu Leu
Glu Asn Phe Asn Pro Pro Phe Lys Leu 635 640 645 650 Cys Leu His Lys
Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn 655 660 665 Ile Ile
Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser 670 675 680
Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser 685
690 695 His Phe Arg Leu Phe Glu Glu Asn Asn Asp Ala Ala Ile Leu Ile
Leu 700 705 710 Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe
Cys Lys Leu 715 720 725 730 Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu
Glu Trp Pro Met Asp Glu 735 740 745 Ala Gln Arg Glu Gly Phe Trp Val
Asn Leu Arg Ala Ala Ile Lys Ser 750 755 760 <210> SEQ ID NO 5
<211> LENGTH: 2715 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (1)..(2712) <220> FEATURE:
<221> NAME/KEY: mat_peptide <222> LOCATION:
(64)..(2712)
<400> SEQUENCE: 5 atg aga cag act ttg cct tgt atc tac ttt tgg
ggg ggc ctt ttg ccc 48 Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp
Gly Gly Leu Leu Pro -20 -15 -10 ttt ggg atg ctg tgt gca tcc tcc acc
acc aag tgc act gtt agc cat 96 Phe Gly Met Leu Cys Ala Ser Ser Thr
Thr Lys Cys Thr Val Ser His -5 -1 1 5 10 gaa gtt gct gac tgc agc
cac ctg aag ttg act cag gta ccc gat gat 144 Glu Val Ala Asp Cys Ser
His Leu Lys Leu Thr Gln Val Pro Asp Asp 15 20 25 cta ccc aca aac
ata aca gtg ttg aac ctt acc cat aat caa ctc aga 192 Leu Pro Thr Asn
Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg 30 35 40 aga tta
cca gcc gcc aac ttc aca agg tat agc cag cta act agc ttg 240 Arg Leu
Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser Leu 45 50 55
gat gta gga ttt aac acc atc tca aaa ctg gag cca gaa ttg tgc cag 288
Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu Leu Cys Gln 60
65 70 75 aaa ctt ccc atg tta aaa gtt ttg aac ctc cag cac aat gag
cta tct 336 Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln His Asn Glu
Leu Ser 80 85 90 caa ctt tct gat aaa acc ttt gcc ttc tgc acg aat
ttg act gaa ctc 384 Gln Leu Ser Asp Lys Thr Phe Ala Phe Cys Thr Asn
Leu Thr Glu Leu 95 100 105 cat ctc atg tcc aac tca atc cag aaa att
aaa aat aat ccc ttt gtc 432 His Leu Met Ser Asn Ser Ile Gln Lys Ile
Lys Asn Asn Pro Phe Val 110 115 120 aag cag aag aat tta atc aca tta
gat ctg tct cat aat ggc ttg tca 480 Lys Gln Lys Asn Leu Ile Thr Leu
Asp Leu Ser His Asn Gly Leu Ser 125 130 135 tct aca aaa tta gga act
cag gtt cag ctg gaa aat ctc caa gag ctt 528 Ser Thr Lys Leu Gly Thr
Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 140 145 150 155 cta tta tca
aac aat aaa att caa gcg cta aaa agt gaa gaa ctg gat 576 Leu Leu Ser
Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp 160 165 170 atc
ttt gcc aat tca tct tta aaa aaa tta gag ttg tca tcg aat caa 624 Ile
Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn Gln 175 180
185 att aaa gag ttt tct cca ggg tgt ttt cac gca att gga aga tta ttt
672 Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly Arg Leu Phe
190 195 200 ggc ctc ttt ctg aac aat gtc cag ctg ggt ccc agc ctt aca
gag aag 720 Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro Ser Leu Thr
Glu Lys 205 210 215 cta tgt ttg gaa tta gca aac aca agc att cgg aat
ctg tct ctg agt 768 Leu Cys Leu Glu Leu Ala Asn Thr Ser Ile Arg Asn
Leu Ser Leu Ser 220 225 230 235 aac agc cag ctg tcc acc acc agc aat
aca act ttc ttg gga cta aag 816 Asn Ser Gln Leu Ser Thr Thr Ser Asn
Thr Thr Phe Leu Gly Leu Lys 240 245 250 tgg aca aat ctc act atg ctc
gat ctt tcc tac aac aac tta aat gtg 864 Trp Thr Asn Leu Thr Met Leu
Asp Leu Ser Tyr Asn Asn Leu Asn Val 255 260 265 gtt ggt aac gat tcc
ttt gct tgg ctt cca caa cta gaa tat ttc ttc 912 Val Gly Asn Asp Ser
Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 270 275 280 cta gag tat
aat aat ata cag cat ttg ttt tct cac tct ttg cac ggg 960 Leu Glu Tyr
Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly 285 290 295 ctt
ttc aat gtg agg tac ctg aat ttg aaa cgg tct ttt act aaa caa 1008
Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys Gln 300
305 310 315 agt att tcc ctt gcc tca ctc ccc aag att gat gat ttt tct
ttt cag 1056 Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp Phe
Ser Phe Gln 320 325 330 tgg cta aaa tgt ttg gag cac ctt aac atg gaa
gat aat gat att cca 1104 Trp Leu Lys Cys Leu Glu His Leu Asn Met
Glu Asp Asn Asp Ile Pro 335 340 345 ggc ata aaa agc aat atg ttc aca
gga ttg ata aac ctg aaa tac tta 1152 Gly Ile Lys Ser Asn Met Phe
Thr Gly Leu Ile Asn Leu Lys Tyr Leu 350 355 360 agt cta tcc aac tcc
ttt aca agt ttg cga act ttg aca aat gaa aca 1200 Ser Leu Ser Asn
Ser Phe Thr Ser Leu Arg Thr Leu Thr Asn Glu Thr 365 370 375 ttt gta
tca ctt gct cat tct ccc tta cac ata ctc aac cta acc aag 1248 Phe
Val Ser Leu Ala His Ser Pro Leu His Ile Leu Asn Leu Thr Lys 380 385
390 395 aat aaa atc tca aaa ata gag agt gat gct ttc tct tgg ttg ggc
cac 1296 Asn Lys Ile Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu
Gly His 400 405 410 cta gaa gta ctt gac ctg ggc ctt aat gaa att ggg
caa gaa ctc aca 1344 Leu Glu Val Leu Asp Leu Gly Leu Asn Glu Ile
Gly Gln Glu Leu Thr 415 420 425 ggc cag gaa tgg aga ggt cta gaa aat
att ttc gaa atc tat ctt tcc 1392 Gly Gln Glu Trp Arg Gly Leu Glu
Asn Ile Phe Glu Ile Tyr Leu Ser 430 435 440 tac aac aag tac ctg cag
ctg act agg aac tcc ttt gcc ttg gtc cca 1440 Tyr Asn Lys Tyr Leu
Gln Leu Thr Arg Asn Ser Phe Ala Leu Val Pro 445 450 455 agc ctt caa
cga ctg atg ctc cga agg gtg gcc ctt aaa aat gtg gat 1488 Ser Leu
Gln Arg Leu Met Leu Arg Arg Val Ala Leu Lys Asn Val Asp 460 465 470
475 agc tct cct tca cca ttc cag cct ctt cgt aac ttg acc att ctg gat
1536 Ser Ser Pro Ser Pro Phe Gln Pro Leu Arg Asn Leu Thr Ile Leu
Asp 480 485 490 cta agc aac aac aac ata gcc aac ata aat gat gac atg
ttg gag ggt 1584 Leu Ser Asn Asn Asn Ile Ala Asn Ile Asn Asp Asp
Met Leu Glu Gly 495 500 505 ctt gag aaa cta gaa att ctc gat ttg cag
cat aac aac tta gca cgg 1632 Leu Glu Lys Leu Glu Ile Leu Asp Leu
Gln His Asn Asn Leu Ala Arg 510 515 520 ctc tgg aaa cac gca aac cct
ggt ggt ccc att tat ttc cta aag ggt 1680 Leu Trp Lys His Ala Asn
Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly 525 530 535 ctg tct cac ctc
cac atc ctt aac ttg gag tcc aac ggc ttt gac gag 1728 Leu Ser His
Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu 540 545 550 555
atc cca gtt gag gtc ttc aag gat tta ttt gaa cta aag atc atc gat
1776 Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys Ile Ile
Asp 560 565 570 tta gga ttg aat aat tta aac aca ctt cca gca tct gtc
ttt aat aat 1824 Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala Ser
Val Phe Asn Asn 575 580 585 cag gtg tct cta aag tca ttg aac ctt cag
aag aat ctc ata aca tcc 1872 Gln Val Ser Leu Lys Ser Leu Asn Leu
Gln Lys Asn Leu Ile Thr Ser 590 595 600 gtt gag aag aag gtt ttc ggg
cca gct ttc agg aac ctg act gag tta 1920 Val Glu Lys Lys Val Phe
Gly Pro Ala Phe Arg Asn Leu Thr Glu Leu 605 610 615 gat atg cgc ttt
aat ccc ttt gat tgc acg tgt gaa agt att gcc tgg 1968 Asp Met Arg
Phe Asn Pro Phe Asp Cys Thr Cys Glu Ser Ile Ala Trp 620 625 630 635
ttt gtt aat tgg att aac gag acc cat acc aac atc cct gag ctg tca
2016 Phe Val Asn Trp Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu
Ser 640 645 650 agc cac tac ctt tgc aac act cca cct cac tat cat ggg
ttc cca gtg 2064 Ser His Tyr Leu Cys Asn Thr Pro Pro His Tyr His
Gly Phe Pro Val 655 660 665 aga ctt ttt gat aca tca tct tgc aaa gac
agt gcc ccc ttt gaa ctc 2112 Arg Leu Phe Asp Thr Ser Ser Cys Lys
Asp Ser Ala Pro Phe Glu Leu 670 675 680 ttt ttc atg atc aat acc agt
atc ctg ttg att ttt atc ttt att gta 2160 Phe Phe Met Ile Asn Thr
Ser Ile Leu Leu Ile Phe Ile Phe Ile Val 685 690 695 ctt ctc atc cac
ttt gag ggc tgg agg ata tct ttt tat tgg aat gtt 2208 Leu Leu Ile
His Phe Glu Gly Trp Arg Ile Ser Phe Tyr Trp Asn Val 700 705 710 715
tca gta cat cga gtt ctt ggt ttc aaa gaa ata gac aga cag aca gaa
2256 Ser Val His Arg Val Leu Gly Phe Lys Glu Ile Asp Arg Gln Thr
Glu 720 725 730 cag ttt gaa tat gca gca tat ata att cat gcc tat aaa
gat aag gat 2304 Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr
Lys Asp Lys Asp 735 740 745 tgg gtc tgg gaa cat ttc tct tca atg gaa
aag gaa gac caa tct ctc 2352 Trp Val Trp Glu His Phe Ser Ser Met
Glu Lys Glu Asp Gln Ser Leu 750 755 760 aaa ttt tgt ctg gaa gaa agg
gac ttt gag gcg ggt gtt ttt gaa cta 2400 Lys Phe Cys Leu Glu Glu
Arg Asp Phe Glu Ala Gly Val Phe Glu Leu 765 770 775 gaa gca att gtt
aac agc atc aaa aga agc aga aaa att att ttt gtt 2448 Glu Ala Ile
Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val 780 785 790 795
ata aca cac cat cta tta aaa gac cca tta tgc aaa aga ttc aag gta
2496 Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys
Val 800 805 810 cat cat gca gtt caa caa gct att gaa caa aat ctg gat
tcc att ata 2544 His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu
Asp Ser Ile Ile 815 820 825 ttg gtt ttc ctt gag gag att cca gat tat
aaa ctg aac cat gca ctc 2592 Leu Val Phe Leu Glu Glu Ile Pro Asp
Tyr Lys Leu Asn His Ala Leu 830 835 840 tgt ttg cga aga gga atg ttt
aaa tct cac tgc atc ttg aac tgg cca 2640 Cys Leu Arg Arg Gly Met
Phe Lys Ser His Cys Ile Leu Asn Trp Pro 845 850 855 gtt cag aaa gaa
cgg ata ggt gcc ttt cgt cat aaa ttg caa gta gca 2688 Val Gln Lys
Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val Ala 860 865 870 875
ctt gga tcc aaa aac tct gta cat taa 2715 Leu Gly Ser Lys Asn Ser
Val His 880 <210> SEQ ID NO 6 <211> LENGTH: 904
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 6 Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp
Gly Gly Leu Leu Pro -20 -15 -10 Phe Gly Met Leu Cys Ala Ser Ser Thr
Thr Lys Cys Thr Val Ser His -5 -1 1 5 10 Glu Val Ala Asp Cys Ser
His Leu Lys Leu Thr Gln Val Pro Asp Asp 15 20 25 Leu Pro Thr Asn
Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg 30 35 40
Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser Leu 45
50 55 Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu Leu Cys
Gln 60 65 70 75 Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln His Asn
Glu Leu Ser 80 85 90 Gln Leu Ser Asp Lys Thr Phe Ala Phe Cys Thr
Asn Leu Thr Glu Leu 95 100 105 His Leu Met Ser Asn Ser Ile Gln Lys
Ile Lys Asn Asn Pro Phe Val 110 115 120 Lys Gln Lys Asn Leu Ile Thr
Leu Asp Leu Ser His Asn Gly Leu Ser 125 130 135 Ser Thr Lys Leu Gly
Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 140 145 150 155 Leu Leu
Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp 160 165 170
Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn Gln 175
180 185 Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly Arg Leu
Phe 190 195 200 Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro Ser Leu
Thr Glu Lys 205 210 215 Leu Cys Leu Glu Leu Ala Asn Thr Ser Ile Arg
Asn Leu Ser Leu Ser 220 225 230 235 Asn Ser Gln Leu Ser Thr Thr Ser
Asn Thr Thr Phe Leu Gly Leu Lys 240 245 250 Trp Thr Asn Leu Thr Met
Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val 255 260 265 Val Gly Asn Asp
Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 270 275 280 Leu Glu
Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly 285 290 295
Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys Gln 300
305 310 315 Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp Phe Ser
Phe Gln 320 325 330 Trp Leu Lys Cys Leu Glu His Leu Asn Met Glu Asp
Asn Asp Ile Pro 335 340 345 Gly Ile Lys Ser Asn Met Phe Thr Gly Leu
Ile Asn Leu Lys Tyr Leu 350 355 360 Ser Leu Ser Asn Ser Phe Thr Ser
Leu Arg Thr Leu Thr Asn Glu Thr 365 370 375 Phe Val Ser Leu Ala His
Ser Pro Leu His Ile Leu Asn Leu Thr Lys 380 385 390 395 Asn Lys Ile
Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu Gly His 400 405 410 Leu
Glu Val Leu Asp Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr 415 420
425 Gly Gln Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr Leu Ser
430 435 440 Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe Ala Leu
Val Pro 445 450 455 Ser Leu Gln Arg Leu Met Leu Arg Arg Val Ala Leu
Lys Asn Val Asp 460 465 470 475 Ser Ser Pro Ser Pro Phe Gln Pro Leu
Arg Asn Leu Thr Ile Leu Asp 480 485 490 Leu Ser Asn Asn Asn Ile Ala
Asn Ile Asn Asp Asp Met Leu Glu Gly 495 500 505 Leu Glu Lys Leu Glu
Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg 510 515 520 Leu Trp Lys
His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly 525 530 535 Leu
Ser His Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu 540 545
550 555 Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys Ile Ile
Asp 560 565 570 Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala Ser Val
Phe Asn Asn 575 580 585 Gln Val Ser Leu Lys Ser Leu Asn Leu Gln Lys
Asn Leu Ile Thr Ser 590 595 600 Val Glu Lys Lys Val Phe Gly Pro Ala
Phe Arg Asn Leu Thr Glu Leu 605 610 615 Asp Met Arg Phe Asn Pro Phe
Asp Cys Thr Cys Glu Ser Ile Ala Trp 620 625 630 635 Phe Val Asn Trp
Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu Ser 640 645 650 Ser His
Tyr Leu Cys Asn Thr Pro Pro His Tyr His Gly Phe Pro Val 655 660 665
Arg Leu Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu Leu 670
675 680 Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile
Val 685 690 695 Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser Phe Tyr
Trp Asn Val 700 705 710 715 Ser Val His Arg Val Leu Gly Phe Lys Glu
Ile Asp Arg Gln Thr Glu 720 725 730 Gln Phe Glu Tyr Ala Ala Tyr Ile
Ile His Ala Tyr Lys Asp Lys Asp 735 740 745 Trp Val Trp Glu His Phe
Ser Ser Met Glu Lys Glu Asp Gln Ser Leu 750 755 760 Lys Phe Cys Leu
Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu 765 770 775 Glu Ala
Ile Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val 780 785 790
795 Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys Val
800 805 810 His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu Asp Ser
Ile Ile 815 820 825 Leu Val Phe Leu Glu Glu Ile Pro Asp Tyr Lys Leu
Asn His Ala Leu 830 835 840 Cys Leu Arg Arg Gly Met Phe Lys Ser His
Cys Ile Leu Asn Trp Pro 845 850 855 Val Gln Lys Glu Arg Ile Gly Ala
Phe Arg His Lys Leu Gln Val Ala 860 865 870 875 Leu Gly Ser Lys Asn
Ser Val His 880 <210> SEQ ID NO 7 <211> LENGTH: 2400
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(2397) <400> SEQUENCE: 7 atg gag ctg aat ttc
tac aaa atc ccc gac aac ctc ccc ttc tca acc 48 Met Glu Leu Asn Phe
Tyr Lys Ile Pro Asp Asn Leu Pro Phe Ser Thr 1 5 10 15 aag aac ctg
gac ctg agc ttt aat ccc ctg agg cat tta ggc agc tat 96 Lys Asn Leu
Asp Leu Ser Phe Asn Pro Leu Arg His Leu Gly Ser Tyr 20 25 30 agc
ttc ttc agt ttc cca gaa ctg cag gtg ctg gat tta tcc agg tgt 144 Ser
Phe Phe Ser Phe Pro Glu Leu Gln Val Leu Asp Leu Ser Arg Cys 35 40
45 gaa atc cag aca att gaa gat ggg gca tat cag agc cta agc cac ctc
192 Glu Ile Gln Thr Ile Glu Asp Gly Ala Tyr Gln Ser Leu Ser His Leu
50 55 60 tct acc tta ata ttg aca gga aac ccc atc cag agt tta gcc
ctg gga 240 Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile Gln Ser Leu Ala
Leu Gly 65 70 75 80 gcc ttt tct gga cta tca agt tta cag aag ctg gtg
gct gtg gag aca 288 Ala Phe Ser Gly Leu Ser Ser Leu Gln Lys Leu Val
Ala Val Glu Thr 85 90 95 aat cta gca tct cta gag aac ttc ccc att
gga cat ctc aaa act ttg 336 Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile
Gly His Leu Lys Thr Leu 100 105 110 aaa gaa ctt aat gtg gct cac aat
ctt atc caa tct ttc aaa tta cct 384 Lys Glu Leu Asn Val Ala His Asn
Leu Ile Gln Ser Phe Lys Leu Pro 115 120 125 gag tat ttt tct aat ctg
acc aat cta gag cac ttg gac ctt tcc agc 432 Glu Tyr Phe Ser Asn Leu
Thr Asn Leu Glu His Leu Asp Leu Ser Ser 130 135 140 aac aag att caa
agt att tat tgc aca gac ttg cgg gtt cta cat caa 480 Asn Lys Ile Gln
Ser Ile Tyr Cys Thr Asp Leu Arg Val Leu His Gln 145 150 155 160 atg
ccc cta ctc aat ctc tct tta gac ctg tcc ctg aac cct atg aac 528 Met
Pro Leu Leu Asn Leu Ser Leu Asp Leu Ser Leu Asn Pro Met Asn 165 170
175 ttt atc caa cca ggt gca ttt aaa gaa att agg ctt cat aag ctg act
576 Phe Ile Gln Pro Gly Ala Phe Lys Glu Ile Arg Leu His Lys Leu Thr
180 185 190 tta aga aat aat ttt gat agt tta aat gta atg aaa act tgt
att caa 624 Leu Arg Asn Asn Phe Asp Ser Leu Asn Val Met Lys Thr Cys
Ile Gln 195 200 205 ggt ctg gct ggt tta gaa gtc cat cgt ttg gtt ctg
gga gaa ttt aga 672 Gly Leu Ala Gly Leu Glu Val His Arg Leu Val Leu
Gly Glu Phe Arg 210 215 220 aat gaa gga aac ttg gaa aag ttt gac aaa
tct gct cta gag ggc ctg 720 Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys
Ser Ala Leu Glu Gly Leu 225 230 235 240 tgc aat ttg acc att gaa gaa
ttc cga tta gca tac tta gac tac tac 768 Cys Asn Leu Thr Ile Glu Glu
Phe Arg Leu Ala Tyr Leu Asp Tyr Tyr 245 250 255 ctc gat gat att att
gac tta ttt aat tgt ttg aca aat gtt tct tca 816 Leu Asp Asp Ile Ile
Asp Leu Phe Asn Cys Leu Thr Asn Val Ser Ser 260 265 270 ttt tcc ctg
gtg agt gtg act att gaa agg gta aaa gac ttt tct tat 864 Phe Ser Leu
Val Ser Val Thr Ile Glu Arg Val Lys Asp Phe Ser Tyr 275 280 285 aat
ttc gga tgg caa cat tta gaa tta gtt aac tgt aaa ttt gga cag 912 Asn
Phe Gly Trp Gln His Leu Glu Leu Val Asn Cys Lys Phe Gly Gln 290 295
300 ttt ccc aca ttg aaa ctc aaa tct ctc aaa agg ctt act ttc act tcc
960 Phe Pro Thr Leu Lys Leu Lys Ser Leu Lys Arg Leu Thr Phe Thr Ser
305 310 315 320 aac aaa ggt ggg aat gct ttt tca gaa gtt gat cta cca
agc ctt gag 1008
Asn Lys Gly Gly Asn Ala Phe Ser Glu Val Asp Leu Pro Ser Leu Glu 325
330 335 ttt cta gat ctc agt aga aat ggc ttg agt ttc aaa ggt tgc tgt
tct 1056 Phe Leu Asp Leu Ser Arg Asn Gly Leu Ser Phe Lys Gly Cys
Cys Ser 340 345 350 caa agt gat ttt ggg aca acc agc cta aag tat tta
gat ctg agc ttc 1104 Gln Ser Asp Phe Gly Thr Thr Ser Leu Lys Tyr
Leu Asp Leu Ser Phe 355 360 365 aat ggt gtt att acc atg agt tca aac
ttc ttg ggc tta gaa caa cta 1152 Asn Gly Val Ile Thr Met Ser Ser
Asn Phe Leu Gly Leu Glu Gln Leu 370 375 380 gaa cat ctg gat ttc cag
cat tcc aat ttg aaa caa atg agt gag ttt 1200 Glu His Leu Asp Phe
Gln His Ser Asn Leu Lys Gln Met Ser Glu Phe 385 390 395 400 tca gta
ttc cta tca ctc aga aac ctc att tac ctt gac att tct cat 1248 Ser
Val Phe Leu Ser Leu Arg Asn Leu Ile Tyr Leu Asp Ile Ser His 405 410
415 act cac acc aga gtt gct ttc aat ggc atc ttc aat ggc ttg tcc agt
1296 Thr His Thr Arg Val Ala Phe Asn Gly Ile Phe Asn Gly Leu Ser
Ser 420 425 430 ctc gaa gtc ttg aaa atg gct ggc aat tct ttc cag gaa
aac ttc ctt 1344 Leu Glu Val Leu Lys Met Ala Gly Asn Ser Phe Gln
Glu Asn Phe Leu 435 440 445 cca gat atc ttc aca gag ctg aga aac ttg
acc ttc ctg gac ctc tct 1392 Pro Asp Ile Phe Thr Glu Leu Arg Asn
Leu Thr Phe Leu Asp Leu Ser 450 455 460 cag tgt caa ctg gag cag ttg
tct cca aca gca ttt aac tca ctc tcc 1440 Gln Cys Gln Leu Glu Gln
Leu Ser Pro Thr Ala Phe Asn Ser Leu Ser 465 470 475 480 agt ctt cag
gta cta aat atg agc cac aac aac ttc ttt tca ttg gat 1488 Ser Leu
Gln Val Leu Asn Met Ser His Asn Asn Phe Phe Ser Leu Asp 485 490 495
acg ttt cct tat aag tgt ctg aac tcc ctc cag gtt ctt gat tac agt
1536 Thr Phe Pro Tyr Lys Cys Leu Asn Ser Leu Gln Val Leu Asp Tyr
Ser 500 505 510 ctc aat cac ata atg act tcc aaa aaa cag gaa cta cag
cat ttt cca 1584 Leu Asn His Ile Met Thr Ser Lys Lys Gln Glu Leu
Gln His Phe Pro 515 520 525 agt agt cta gct ttc tta aat ctt act cag
aat gac ttt gct tgt act 1632 Ser Ser Leu Ala Phe Leu Asn Leu Thr
Gln Asn Asp Phe Ala Cys Thr 530 535 540 tgt gaa cac cag agt ttc ctg
caa tgg atc aag gac cag agg cag ctc 1680 Cys Glu His Gln Ser Phe
Leu Gln Trp Ile Lys Asp Gln Arg Gln Leu 545 550 555 560 ttg gtg gaa
gtt gaa cga atg gaa tgt gca aca cct tca gat aag cag 1728 Leu Val
Glu Val Glu Arg Met Glu Cys Ala Thr Pro Ser Asp Lys Gln 565 570 575
ggc atg cct gtg ctg agt ttg aat atc acc tgt cag atg aat aag acc
1776 Gly Met Pro Val Leu Ser Leu Asn Ile Thr Cys Gln Met Asn Lys
Thr 580 585 590 atc att ggt gtg tcg gtc ctc agt gtg ctt gta gta tct
gtt gta gca 1824 Ile Ile Gly Val Ser Val Leu Ser Val Leu Val Val
Ser Val Val Ala 595 600 605 gtt ctg gtc tat aag ttc tat ttt cac ctg
atg ctt ctt gct ggc tgc 1872 Val Leu Val Tyr Lys Phe Tyr Phe His
Leu Met Leu Leu Ala Gly Cys 610 615 620 ata aag tat ggt aga ggt gaa
aac atc tat gat gcc ttt gtt atc tac 1920 Ile Lys Tyr Gly Arg Gly
Glu Asn Ile Tyr Asp Ala Phe Val Ile Tyr 625 630 635 640 tca agc cag
gat gag gac tgg gta agg aat gag cta gta aag aat tta 1968 Ser Ser
Gln Asp Glu Asp Trp Val Arg Asn Glu Leu Val Lys Asn Leu 645 650 655
gaa gaa ggg gtg cct cca ttt cag ctc tgc ctt cac tac aga gac ttt
2016 Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu His Tyr Arg Asp
Phe 660 665 670 att ccc ggt gtg gcc att gct gcc aac atc atc cat gaa
ggt ttc cat 2064 Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile His
Glu Gly Phe His 675 680 685 aaa agc cga aag gtg att gtt gtg gtg tcc
cag cac ttc atc cag agc 2112 Lys Ser Arg Lys Val Ile Val Val Val
Ser Gln His Phe Ile Gln Ser 690 695 700 cgc tgg tgt atc ttt gaa tat
gag att gct cag acc tgg cag ttt ctg 2160 Arg Trp Cys Ile Phe Glu
Tyr Glu Ile Ala Gln Thr Trp Gln Phe Leu 705 710 715 720 agc agt cgt
gct ggt atc atc ttc att gtc ctg cag aag gtg gag aag 2208 Ser Ser
Arg Ala Gly Ile Ile Phe Ile Val Leu Gln Lys Val Glu Lys 725 730 735
acc ctg ctc agg cag cag gtg gag ctg tac cgc ctt ctc agc agg aac
2256 Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg Leu Leu Ser Arg
Asn 740 745 750 act tac ctg gag tgg gag gac agt gtc ctg ggg cgg cac
atc ttc tgg 2304 Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly Arg
His Ile Phe Trp 755 760 765 aga cga ctc aga aaa gcc ctg ctg gat ggt
aaa tca tgg aat cca gaa 2352 Arg Arg Leu Arg Lys Ala Leu Leu Asp
Gly Lys Ser Trp Asn Pro Glu 770 775 780 gga aca gtg ggt aca gga tgc
aat tgg cag gaa gca aca tct atc tga 2400 Gly Thr Val Gly Thr Gly
Cys Asn Trp Gln Glu Ala Thr Ser Ile 785 790 795 <210> SEQ ID
NO 8 <211> LENGTH: 799 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 8 Met Glu Leu Asn Phe
Tyr Lys Ile Pro Asp Asn Leu Pro Phe Ser Thr 1 5 10 15 Lys Asn Leu
Asp Leu Ser Phe Asn Pro Leu Arg His Leu Gly Ser Tyr 20 25 30 Ser
Phe Phe Ser Phe Pro Glu Leu Gln Val Leu Asp Leu Ser Arg Cys 35 40
45 Glu Ile Gln Thr Ile Glu Asp Gly Ala Tyr Gln Ser Leu Ser His Leu
50 55 60 Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile Gln Ser Leu Ala
Leu Gly 65 70 75 80 Ala Phe Ser Gly Leu Ser Ser Leu Gln Lys Leu Val
Ala Val Glu Thr 85 90 95 Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile
Gly His Leu Lys Thr Leu 100 105 110 Lys Glu Leu Asn Val Ala His Asn
Leu Ile Gln Ser Phe Lys Leu Pro 115 120 125 Glu Tyr Phe Ser Asn Leu
Thr Asn Leu Glu His Leu Asp Leu Ser Ser 130 135 140 Asn Lys Ile Gln
Ser Ile Tyr Cys Thr Asp Leu Arg Val Leu His Gln 145 150 155 160 Met
Pro Leu Leu Asn Leu Ser Leu Asp Leu Ser Leu Asn Pro Met Asn 165 170
175 Phe Ile Gln Pro Gly Ala Phe Lys Glu Ile Arg Leu His Lys Leu Thr
180 185 190 Leu Arg Asn Asn Phe Asp Ser Leu Asn Val Met Lys Thr Cys
Ile Gln 195 200 205 Gly Leu Ala Gly Leu Glu Val His Arg Leu Val Leu
Gly Glu Phe Arg 210 215 220 Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys
Ser Ala Leu Glu Gly Leu 225 230 235 240 Cys Asn Leu Thr Ile Glu Glu
Phe Arg Leu Ala Tyr Leu Asp Tyr Tyr 245 250 255 Leu Asp Asp Ile Ile
Asp Leu Phe Asn Cys Leu Thr Asn Val Ser Ser 260 265 270 Phe Ser Leu
Val Ser Val Thr Ile Glu Arg Val Lys Asp Phe Ser Tyr 275 280 285 Asn
Phe Gly Trp Gln His Leu Glu Leu Val Asn Cys Lys Phe Gly Gln 290 295
300 Phe Pro Thr Leu Lys Leu Lys Ser Leu Lys Arg Leu Thr Phe Thr Ser
305 310 315 320 Asn Lys Gly Gly Asn Ala Phe Ser Glu Val Asp Leu Pro
Ser Leu Glu 325 330 335 Phe Leu Asp Leu Ser Arg Asn Gly Leu Ser Phe
Lys Gly Cys Cys Ser 340 345 350 Gln Ser Asp Phe Gly Thr Thr Ser Leu
Lys Tyr Leu Asp Leu Ser Phe 355 360 365 Asn Gly Val Ile Thr Met Ser
Ser Asn Phe Leu Gly Leu Glu Gln Leu 370 375 380 Glu His Leu Asp Phe
Gln His Ser Asn Leu Lys Gln Met Ser Glu Phe 385 390 395 400 Ser Val
Phe Leu Ser Leu Arg Asn Leu Ile Tyr Leu Asp Ile Ser His 405 410 415
Thr His Thr Arg Val Ala Phe Asn Gly Ile Phe Asn Gly Leu Ser Ser 420
425 430 Leu Glu Val Leu Lys Met Ala Gly Asn Ser Phe Gln Glu Asn Phe
Leu 435 440 445 Pro Asp Ile Phe Thr Glu Leu Arg Asn Leu Thr Phe Leu
Asp Leu Ser 450 455 460 Gln Cys Gln Leu Glu Gln Leu Ser Pro Thr Ala
Phe Asn Ser Leu Ser 465 470 475 480 Ser Leu Gln Val Leu Asn Met Ser
His Asn Asn Phe Phe Ser Leu Asp 485 490 495 Thr Phe Pro Tyr Lys Cys
Leu Asn Ser Leu Gln Val Leu Asp Tyr Ser 500 505 510 Leu Asn His Ile
Met Thr Ser Lys Lys Gln Glu Leu Gln His Phe Pro 515 520 525 Ser Ser
Leu Ala Phe Leu Asn Leu Thr Gln Asn Asp Phe Ala Cys Thr 530 535 540
Cys Glu His Gln Ser Phe Leu Gln Trp Ile Lys Asp Gln Arg Gln Leu 545
550 555 560 Leu Val Glu Val Glu Arg Met Glu Cys Ala Thr Pro Ser Asp
Lys Gln 565 570 575 Gly Met Pro Val Leu Ser Leu Asn Ile Thr Cys Gln
Met Asn Lys Thr 580 585 590 Ile Ile Gly Val Ser Val Leu Ser Val Leu
Val Val Ser Val Val Ala 595 600 605 Val Leu Val Tyr Lys Phe Tyr Phe
His Leu Met Leu Leu Ala Gly Cys 610 615 620 Ile Lys Tyr Gly Arg Gly
Glu Asn Ile Tyr Asp Ala Phe Val Ile Tyr 625 630 635 640 Ser Ser Gln
Asp Glu Asp Trp Val Arg Asn Glu Leu Val Lys Asn Leu 645 650 655 Glu
Glu Gly Val Pro Pro Phe Gln Leu Cys Leu His Tyr Arg Asp Phe
660 665 670 Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile His Glu Gly
Phe His 675 680 685 Lys Ser Arg Lys Val Ile Val Val Val Ser Gln His
Phe Ile Gln Ser 690 695 700 Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala
Gln Thr Trp Gln Phe Leu 705 710 715 720 Ser Ser Arg Ala Gly Ile Ile
Phe Ile Val Leu Gln Lys Val Glu Lys 725 730 735 Thr Leu Leu Arg Gln
Gln Val Glu Leu Tyr Arg Leu Leu Ser Arg Asn 740 745 750 Thr Tyr Leu
Glu Trp Glu Asp Ser Val Leu Gly Arg His Ile Phe Trp 755 760 765 Arg
Arg Leu Arg Lys Ala Leu Leu Asp Gly Lys Ser Trp Asn Pro Glu 770 775
780 Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu Ala Thr Ser Ile 785
790 795 <210> SEQ ID NO 9 <211> LENGTH: 1275
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(1095) <400> SEQUENCE: 9 tgt tgg gat gtt ttt
gag gga ctt tct cat ctt caa gtt ctg tat ttg 48 Cys Trp Asp Val Phe
Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu 1 5 10 15 aat cat aac
tat ctt aat tcc ctt cca cca gga gta ttt agc cat ctg 96 Asn His Asn
Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu 20 25 30 act
gca tta agg gga cta agc ctc aac tcc aac agg ctg aca gtt ctt 144 Thr
Ala Leu Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu 35 40
45 tct cac aat gat tta cct gct aat tta gag atc ctg gac ata tcc agg
192 Ser His Asn Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg
50 55 60 aac cag ctc cta gct cct aat cct gat gta ttt gta tca ctt
agt gtc 240 Asn Gln Leu Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu
Ser Val 65 70 75 80 ttg gat ata act cat aac aag ttc att tgt gaa tgt
gaa ctt agc act 288 Leu Asp Ile Thr His Asn Lys Phe Ile Cys Glu Cys
Glu Leu Ser Thr 85 90 95 ttt atc aat tgg ctt aat cac acc aat gtc
act ata gct ggg cct cct 336 Phe Ile Asn Trp Leu Asn His Thr Asn Val
Thr Ile Ala Gly Pro Pro 100 105 110 gca gac ata tat tgt gtg tac cct
gac tcg ttc tct ggg gtt tcc ctc 384 Ala Asp Ile Tyr Cys Val Tyr Pro
Asp Ser Phe Ser Gly Val Ser Leu 115 120 125 ttc tct ctt tcc acg gaa
ggt tgt gat gaa gag gaa gtc tta aag tcc 432 Phe Ser Leu Ser Thr Glu
Gly Cys Asp Glu Glu Glu Val Leu Lys Ser 130 135 140 cta aag ttc tcc
ctt ttc att gta tgc act gtc act ctg act ctg ttc 480 Leu Lys Phe Ser
Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe 145 150 155 160 ctc
atg acc atc ctc aca gtc aca aag ttc cgg ggc ttc tgt ttt atc 528 Leu
Met Thr Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile 165 170
175 tgt tat aag aca gcc cag aga ctg gtg ttc aag gac cat ccc cag ggc
576 Cys Tyr Lys Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly
180 185 190 aca gaa cct gat atg tac aaa tat gat gcc tat ttg tgc ttc
agc agc 624 Thr Glu Pro Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe
Ser Ser 195 200 205 aaa gac ttc aca tgg gtg cag aat gct ttg ctc aaa
cac ctg gac act 672 Lys Asp Phe Thr Trp Val Gln Asn Ala Leu Leu Lys
His Leu Asp Thr 210 215 220 caa tac agt gac caa aac aga ttc aac ctg
tgc ttt gaa gaa aga gac 720 Gln Tyr Ser Asp Gln Asn Arg Phe Asn Leu
Cys Phe Glu Glu Arg Asp 225 230 235 240 ttt gtc cca gga gaa aac cgc
att gcc aat atc cag gat gcc atc tgg 768 Phe Val Pro Gly Glu Asn Arg
Ile Ala Asn Ile Gln Asp Ala Ile Trp 245 250 255 aac agt aga aag atc
gtt tgt ctt gtg agc aga cac ttc ctt aga gat 816 Asn Ser Arg Lys Ile
Val Cys Leu Val Ser Arg His Phe Leu Arg Asp 260 265 270 ggc tgg tgc
ctt gaa gcc ttc agt tat gcc cag ggc agg tgc tta tct 864 Gly Trp Cys
Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser 275 280 285 gac
ctt aac agt gct ctc atc atg gtg gtg gtt ggg tcc ttg tcc cag 912 Asp
Leu Asn Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln 290 295
300 tac cag ttg atg aaa cat caa tcc atc aga ggc ttt gta cag aaa cag
960 Tyr Gln Leu Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln
305 310 315 320 cag tat ttg agg tgg cct gag gat ctc cag gat gtt ggc
tgg ttt ctt 1008 Gln Tyr Leu Arg Trp Pro Glu Asp Leu Gln Asp Val
Gly Trp Phe Leu 325 330 335 cat aaa ctc tct caa cag ata cta aag aaa
gaa aag gaa aag aag aaa 1056 His Lys Leu Ser Gln Gln Ile Leu Lys
Lys Glu Lys Glu Lys Lys Lys 340 345 350 gac aat aac att ccg ttg caa
act gta gca acc atc tcc taatcaaagg 1105 Asp Asn Asn Ile Pro Leu Gln
Thr Val Ala Thr Ile Ser 355 360 365 agcaatttcc aacttatctc
aagccacaaa taactcttca ctttgtattt gcaccaagtt 1165 atcattttgg
ggtcctctct ggaggttttt tttttctttt tgctactatg aaaacaacat 1225
aaatctctca attttcgtat caaaaaaaaa aaaaaaaaaa tggcggccgc 1275
<210> SEQ ID NO 10 <211> LENGTH: 365 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 10 Cys
Trp Asp Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu 1 5 10
15 Asn His Asn Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu
20 25 30 Thr Ala Leu Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr
Val Leu 35 40 45 Ser His Asn Asp Leu Pro Ala Asn Leu Glu Ile Leu
Asp Ile Ser Arg 50 55 60 Asn Gln Leu Leu Ala Pro Asn Pro Asp Val
Phe Val Ser Leu Ser Val 65 70 75 80 Leu Asp Ile Thr His Asn Lys Phe
Ile Cys Glu Cys Glu Leu Ser Thr 85 90 95 Phe Ile Asn Trp Leu Asn
His Thr Asn Val Thr Ile Ala Gly Pro Pro 100 105 110 Ala Asp Ile Tyr
Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu 115 120 125 Phe Ser
Leu Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser 130 135 140
Leu Lys Phe Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe 145
150 155 160 Leu Met Thr Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys
Phe Ile 165 170 175 Cys Tyr Lys Thr Ala Gln Arg Leu Val Phe Lys Asp
His Pro Gln Gly 180 185 190 Thr Glu Pro Asp Met Tyr Lys Tyr Asp Ala
Tyr Leu Cys Phe Ser Ser 195 200 205 Lys Asp Phe Thr Trp Val Gln Asn
Ala Leu Leu Lys His Leu Asp Thr 210 215 220 Gln Tyr Ser Asp Gln Asn
Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp 225 230 235 240 Phe Val Pro
Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp 245 250 255 Asn
Ser Arg Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp 260 265
270 Gly Trp Cys Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser
275 280 285 Asp Leu Asn Ser Ala Leu Ile Met Val Val Val Gly Ser Leu
Ser Gln 290 295 300 Tyr Gln Leu Met Lys His Gln Ser Ile Arg Gly Phe
Val Gln Lys Gln 305 310 315 320 Gln Tyr Leu Arg Trp Pro Glu Asp Leu
Gln Asp Val Gly Trp Phe Leu 325 330 335 His Lys Leu Ser Gln Gln Ile
Leu Lys Lys Glu Lys Glu Lys Lys Lys 340 345 350 Asp Asn Asn Ile Pro
Leu Gln Thr Val Ala Thr Ile Ser 355 360 365 <210> SEQ ID NO
11 <211> LENGTH: 3138 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (1)..(3135) <400> SEQUENCE: 11 atg
tgg aca ctg aag aga cta att ctt atc ctt ttt aac ata atc cta 48 Met
Trp Thr Leu Lys Arg Leu Ile Leu Ile Leu Phe Asn Ile Ile Leu 1 5 10
15 att tcc aaa ctc ctt ggg gct aga tgg ttt cct aaa act ctg ccc tgt
96 Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys Thr Leu Pro Cys
20 25 30 gat gtc act ctg gat gtt cca aag aac cat gtg atc gtg gac
tgc aca 144 Asp Val Thr Leu Asp Val Pro Lys Asn His Val Ile Val Asp
Cys Thr 35 40 45 gac aag cat ttg aca gaa att cct gga ggt att ccc
acg aac acc acg 192 Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro
Thr Asn Thr Thr 50 55 60 aac ctc acc ctc acc att aac cac ata cca
gac atc tcc cca gcg tcc 240 Asn Leu Thr Leu Thr Ile Asn His Ile Pro
Asp Ile Ser Pro Ala Ser 65 70 75 80 ttt cac aga ctg gac cat ctg gta
gag atc gat ttc aga tgc aac tgt 288 Phe His Arg Leu Asp His Leu Val
Glu Ile Asp Phe Arg Cys Asn Cys 85 90 95 gta cct att cca ctg ggg
tca aaa aac aac atg tgc atc aag agg ctg 336 Val Pro Ile Pro Leu Gly
Ser Lys Asn Asn Met Cys Ile Lys Arg Leu 100 105 110
cag att aaa ccc aga agc ttt agt gga ctc act tat tta aaa tcc ctt 384
Gln Ile Lys Pro Arg Ser Phe Ser Gly Leu Thr Tyr Leu Lys Ser Leu 115
120 125 tac ctg gat gga aac cag cta cta gag ata ccg cag ggc ctc ccg
cct 432 Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln Gly Leu Pro
Pro 130 135 140 agc tta cag ctt ctc agc ctt gag gcc aac aac atc ttt
tcc atc aga 480 Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile Phe
Ser Ile Arg 145 150 155 160 aaa gag aat cta aca gaa ctg gcc aac ata
gaa ata ctc tac ctg ggc 528 Lys Glu Asn Leu Thr Glu Leu Ala Asn Ile
Glu Ile Leu Tyr Leu Gly 165 170 175 caa aac tgt tat tat cga aat cct
tgt tat gtt tca tat tca ata gag 576 Gln Asn Cys Tyr Tyr Arg Asn Pro
Cys Tyr Val Ser Tyr Ser Ile Glu 180 185 190 aaa gat gcc ttc cta aac
ttg aca aag tta aaa gtg ctc tcc ctg aaa 624 Lys Asp Ala Phe Leu Asn
Leu Thr Lys Leu Lys Val Leu Ser Leu Lys 195 200 205 gat aac aat gtc
aca gcc gtc cct act gtt ttg cca tct act tta aca 672 Asp Asn Asn Val
Thr Ala Val Pro Thr Val Leu Pro Ser Thr Leu Thr 210 215 220 gaa cta
tat ctc tac aac aac atg att gca aaa atc caa gaa gat gat 720 Glu Leu
Tyr Leu Tyr Asn Asn Met Ile Ala Lys Ile Gln Glu Asp Asp 225 230 235
240 ttt aat aac ctc aac caa tta caa att ctt gac cta agt gga aat tgc
768 Phe Asn Asn Leu Asn Gln Leu Gln Ile Leu Asp Leu Ser Gly Asn Cys
245 250 255 cct cgt tgt tat aat gcc cca ttt cct tgt gcg ccg tgt aaa
aat aat 816 Pro Arg Cys Tyr Asn Ala Pro Phe Pro Cys Ala Pro Cys Lys
Asn Asn 260 265 270 tct ccc cta cag atc cct gta aat gct ttt gat gcg
ctg aca gaa tta 864 Ser Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala
Leu Thr Glu Leu 275 280 285 aaa gtt tta cgt cta cac agt aac tct ctt
cag cat gtg ccc cca aga 912 Lys Val Leu Arg Leu His Ser Asn Ser Leu
Gln His Val Pro Pro Arg 290 295 300 tgg ttt aag aac atc aac aaa ctc
cag gaa ctg gat ctg tcc caa aac 960 Trp Phe Lys Asn Ile Asn Lys Leu
Gln Glu Leu Asp Leu Ser Gln Asn 305 310 315 320 ttc ttg gcc aaa gaa
att ggg gat gct aaa ttt ctg cat ttt ctc ccc 1008 Phe Leu Ala Lys
Glu Ile Gly Asp Ala Lys Phe Leu His Phe Leu Pro 325 330 335 agc ctc
atc caa ttg gat ctg tct ttc aat ttt gaa ctt cag gtc tat 1056 Ser
Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe Glu Leu Gln Val Tyr 340 345
350 cgt gca tct atg aat cta tca caa gca ttt tct tca ctg aaa agc ctg
1104 Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser Ser Leu Lys Ser
Leu 355 360 365 aaa att ctg cgg atc aga gga tat gtc ttt aaa gag ttg
aaa agc ttt 1152 Lys Ile Leu Arg Ile Arg Gly Tyr Val Phe Lys Glu
Leu Lys Ser Phe 370 375 380 aac ctc tcg cca tta cat aat ctt caa aat
ctt gaa gtt ctt gat ctt 1200 Asn Leu Ser Pro Leu His Asn Leu Gln
Asn Leu Glu Val Leu Asp Leu 385 390 395 400 ggc act aac ttt ata aaa
att gct aac ctc agc atg ttt aaa caa ttt 1248 Gly Thr Asn Phe Ile
Lys Ile Ala Asn Leu Ser Met Phe Lys Gln Phe 405 410 415 aaa aga ctg
aaa gtc ata gat ctt tca gtg aat aaa ata tca cct tca 1296 Lys Arg
Leu Lys Val Ile Asp Leu Ser Val Asn Lys Ile Ser Pro Ser 420 425 430
gga gat tca agt gaa gtt ggc ttc tgc tca aat gcc aga act tct gta
1344 Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg Thr Ser
Val 435 440 445 gaa agt tat gaa ccc cag gtc ctg gaa caa tta cat tat
ttc aga tat 1392 Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His
Tyr Phe Arg Tyr 450 455 460 gat aag tat gca agg agt tgc aga ttc aaa
aac aaa gag gct tct ttc 1440 Asp Lys Tyr Ala Arg Ser Cys Arg Phe
Lys Asn Lys Glu Ala Ser Phe 465 470 475 480 atg tct gtt aat gaa agc
tgc tac aag tat ggg cag acc ttg gat cta 1488 Met Ser Val Asn Glu
Ser Cys Tyr Lys Tyr Gly Gln Thr Leu Asp Leu 485 490 495 agt aaa aat
agt ata ttt ttt gtc aag tcc tct gat ttt cag cat ctt 1536 Ser Lys
Asn Ser Ile Phe Phe Val Lys Ser Ser Asp Phe Gln His Leu 500 505 510
tct ttc ctc aaa tgc ctg aat ctg tca gga aat ctc att agc caa act
1584 Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu Ile Ser Gln
Thr 515 520 525 ctt aat ggc agt gaa ttc caa cct tta gca gag ctg aga
tat ttg gac 1632 Leu Asn Gly Ser Glu Phe Gln Pro Leu Ala Glu Leu
Arg Tyr Leu Asp 530 535 540 ttc tcc aac aac cgg ctt gat tta ctc cat
tca aca gca ttt gaa gag 1680 Phe Ser Asn Asn Arg Leu Asp Leu Leu
His Ser Thr Ala Phe Glu Glu 545 550 555 560 ctt cac aaa ctg gaa gtt
ctg gat ata agc agt aat agc cat tat ttt 1728 Leu His Lys Leu Glu
Val Leu Asp Ile Ser Ser Asn Ser His Tyr Phe 565 570 575 caa tca gaa
gga att act cat atg cta aac ttt acc aag aac cta aag 1776 Gln Ser
Glu Gly Ile Thr His Met Leu Asn Phe Thr Lys Asn Leu Lys 580 585 590
gtt ctg cag aaa ctg atg atg aac gac aat gac atc tct tcc tcc acc
1824 Val Leu Gln Lys Leu Met Met Asn Asp Asn Asp Ile Ser Ser Ser
Thr 595 600 605 agc agg acc atg gag agt gag tct ctt aga act ctg gaa
ttc aga gga 1872 Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Thr Leu
Glu Phe Arg Gly 610 615 620 aat cac tta gat gtt tta tgg aga gaa ggt
gat aac aga tac tta caa 1920 Asn His Leu Asp Val Leu Trp Arg Glu
Gly Asp Asn Arg Tyr Leu Gln 625 630 635 640 tta ttc aag aat ctg cta
aaa tta gag gaa tta gac atc tct aaa aat 1968 Leu Phe Lys Asn Leu
Leu Lys Leu Glu Glu Leu Asp Ile Ser Lys Asn 645 650 655 tcc cta agt
ttc ttg cct tct gga gtt ttt gat ggt atg cct cca aat 2016 Ser Leu
Ser Phe Leu Pro Ser Gly Val Phe Asp Gly Met Pro Pro Asn 660 665 670
cta aag aat ctc tct ttg gcc aaa aat ggg ctc aaa tct ttc agt tgg
2064 Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys Ser Phe Ser
Trp 675 680 685 aag aaa ctc cag tgt cta aag aac ctg gaa act ttg gac
ctc agc cac 2112 Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu
Asp Leu Ser His 690 695 700 aac caa ctg acc act gtc cct gag aga tta
tcc aac tgt tcc aga agc 2160 Asn Gln Leu Thr Thr Val Pro Glu Arg
Leu Ser Asn Cys Ser Arg Ser 705 710 715 720 ctc aag aat ctg att ctt
aag aat aat caa atc agg agt ctg acg aag 2208 Leu Lys Asn Leu Ile
Leu Lys Asn Asn Gln Ile Arg Ser Leu Thr Lys 725 730 735 tat ttt cta
caa gat gcc ttc cag ttg cga tat ctg gat ctc agc tca 2256 Tyr Phe
Leu Gln Asp Ala Phe Gln Leu Arg Tyr Leu Asp Leu Ser Ser 740 745 750
aat aaa atc cag atg atc caa aag acc agc ttc cca gaa aat gtc ctc
2304 Asn Lys Ile Gln Met Ile Gln Lys Thr Ser Phe Pro Glu Asn Val
Leu 755 760 765 aac aat ctg aag atg ttg ctt ttg cat cat aat cgg ttt
ctg tgc acc 2352 Asn Asn Leu Lys Met Leu Leu Leu His His Asn Arg
Phe Leu Cys Thr 770 775 780 tgt gat gct gtg tgg ttt gtc tgg tgg gtt
aac cat acg gag gtg act 2400 Cys Asp Ala Val Trp Phe Val Trp Trp
Val Asn His Thr Glu Val Thr 785 790 795 800 att cct tac ctg gcc aca
gat gtg act tgt gtg ggg cca gga gca cac 2448 Ile Pro Tyr Leu Ala
Thr Asp Val Thr Cys Val Gly Pro Gly Ala His 805 810 815 aag ggc caa
agt gtg atc tcc ctg gat ctg tac acc tgt gag tta gat 2496 Lys Gly
Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr Cys Glu Leu Asp 820 825 830
ctg act aac ctg att ctg ttc tca ctt tcc ata tct gta tct ctc ttt
2544 Leu Thr Asn Leu Ile Leu Phe Ser Leu Ser Ile Ser Val Ser Leu
Phe 835 840 845 ctc atg gtg atg atg aca gca agt cac ctc tat ttc tgg
gat gtg tgg 2592 Leu Met Val Met Met Thr Ala Ser His Leu Tyr Phe
Trp Asp Val Trp 850 855 860 tat att tac cat ttc tgt aag gcc aag ata
aag ggg tat cag cgt cta 2640 Tyr Ile Tyr His Phe Cys Lys Ala Lys
Ile Lys Gly Tyr Gln Arg Leu 865 870 875 880 ata tca cca gac tgt tgc
tat gat gct ttt att gtg tat gac act aaa 2688 Ile Ser Pro Asp Cys
Cys Tyr Asp Ala Phe Ile Val Tyr Asp Thr Lys 885 890 895 gac cca gct
gtg acc gag tgg gtt ttg gct gag ctg gtg gcc aaa ctg 2736 Asp Pro
Ala Val Thr Glu Trp Val Leu Ala Glu Leu Val Ala Lys Leu 900 905 910
gaa gac cca aga gag aaa cat ttt aat tta tgt ctc gag gaa agg gac
2784 Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys Leu Glu Glu Arg
Asp 915 920 925 tgg tta cca ggg cag cca gtt ctg gaa aac ctt tcc cag
agc ata cag 2832 Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser
Gln Ser Ile Gln 930 935 940 ctt agc aaa aag aca gtg ttt gtg atg aca
gac aag tat gca aag act 2880 Leu Ser Lys Lys Thr Val Phe Val Met
Thr Asp Lys Tyr Ala Lys Thr 945 950 955 960 gaa aat ttt aag ata gca
ttt tac ttg tcc cat cag agg ctc atg gat 2928 Glu Asn Phe Lys Ile
Ala Phe Tyr Leu Ser His Gln Arg Leu Met Asp 965 970 975 gaa aaa gtt
gat gtg att atc ttg ata ttt ctt gag aag ccc ttt cag 2976 Glu Lys
Val Asp Val Ile Ile Leu Ile Phe Leu Glu Lys Pro Phe Gln 980 985 990
aag tcc aag ttc ctc cag ctc cgg aaa agg ctc tgt ggg agt tct gtc
3024 Lys Ser Lys Phe Leu Gln Leu Arg Lys Arg Leu Cys Gly Ser Ser
Val 995 1000 1005 ctt gag tgg cca aca aac ccg caa gct cac cca tac
ttc tgg cag 3069 Leu Glu Trp Pro Thr Asn Pro Gln Ala His Pro Tyr
Phe Trp Gln 1010 1015 1020 tgt cta aag aac gcc ctg gcc aca gac aat
cat gtg gcc tat agt 3114 Cys Leu Lys Asn Ala Leu Ala Thr Asp Asn
His Val Ala Tyr Ser 1025 1030 1035 cag gtg ttc aag gaa acg gtc tag
3138 Gln Val Phe Lys Glu Thr Val 1040 1045 <210> SEQ ID NO 12
<211> LENGTH: 1045 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 12 Met Trp Thr Leu Lys
Arg Leu Ile Leu Ile Leu Phe Asn Ile Ile Leu 1 5 10 15 Ile Ser Lys
Leu Leu Gly Ala Arg Trp Phe Pro Lys Thr Leu Pro Cys 20 25 30 Asp
Val Thr Leu Asp Val Pro Lys Asn His Val Ile Val Asp Cys Thr
35 40 45 Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro Thr Asn
Thr Thr 50 55 60 Asn Leu Thr Leu Thr Ile Asn His Ile Pro Asp Ile
Ser Pro Ala Ser 65 70 75 80 Phe His Arg Leu Asp His Leu Val Glu Ile
Asp Phe Arg Cys Asn Cys 85 90 95 Val Pro Ile Pro Leu Gly Ser Lys
Asn Asn Met Cys Ile Lys Arg Leu 100 105 110 Gln Ile Lys Pro Arg Ser
Phe Ser Gly Leu Thr Tyr Leu Lys Ser Leu 115 120 125 Tyr Leu Asp Gly
Asn Gln Leu Leu Glu Ile Pro Gln Gly Leu Pro Pro 130 135 140 Ser Leu
Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile Phe Ser Ile Arg 145 150 155
160 Lys Glu Asn Leu Thr Glu Leu Ala Asn Ile Glu Ile Leu Tyr Leu Gly
165 170 175 Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser Tyr Ser
Ile Glu 180 185 190 Lys Asp Ala Phe Leu Asn Leu Thr Lys Leu Lys Val
Leu Ser Leu Lys 195 200 205 Asp Asn Asn Val Thr Ala Val Pro Thr Val
Leu Pro Ser Thr Leu Thr 210 215 220 Glu Leu Tyr Leu Tyr Asn Asn Met
Ile Ala Lys Ile Gln Glu Asp Asp 225 230 235 240 Phe Asn Asn Leu Asn
Gln Leu Gln Ile Leu Asp Leu Ser Gly Asn Cys 245 250 255 Pro Arg Cys
Tyr Asn Ala Pro Phe Pro Cys Ala Pro Cys Lys Asn Asn 260 265 270 Ser
Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala Leu Thr Glu Leu 275 280
285 Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His Val Pro Pro Arg
290 295 300 Trp Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp Leu Ser
Gln Asn 305 310 315 320 Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe
Leu His Phe Leu Pro 325 330 335 Ser Leu Ile Gln Leu Asp Leu Ser Phe
Asn Phe Glu Leu Gln Val Tyr 340 345 350 Arg Ala Ser Met Asn Leu Ser
Gln Ala Phe Ser Ser Leu Lys Ser Leu 355 360 365 Lys Ile Leu Arg Ile
Arg Gly Tyr Val Phe Lys Glu Leu Lys Ser Phe 370 375 380 Asn Leu Ser
Pro Leu His Asn Leu Gln Asn Leu Glu Val Leu Asp Leu 385 390 395 400
Gly Thr Asn Phe Ile Lys Ile Ala Asn Leu Ser Met Phe Lys Gln Phe 405
410 415 Lys Arg Leu Lys Val Ile Asp Leu Ser Val Asn Lys Ile Ser Pro
Ser 420 425 430 Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg
Thr Ser Val 435 440 445 Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu
His Tyr Phe Arg Tyr 450 455 460 Asp Lys Tyr Ala Arg Ser Cys Arg Phe
Lys Asn Lys Glu Ala Ser Phe 465 470 475 480 Met Ser Val Asn Glu Ser
Cys Tyr Lys Tyr Gly Gln Thr Leu Asp Leu 485 490 495 Ser Lys Asn Ser
Ile Phe Phe Val Lys Ser Ser Asp Phe Gln His Leu 500 505 510 Ser Phe
Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu Ile Ser Gln Thr 515 520 525
Leu Asn Gly Ser Glu Phe Gln Pro Leu Ala Glu Leu Arg Tyr Leu Asp 530
535 540 Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr Ala Phe Glu
Glu 545 550 555 560 Leu His Lys Leu Glu Val Leu Asp Ile Ser Ser Asn
Ser His Tyr Phe 565 570 575 Gln Ser Glu Gly Ile Thr His Met Leu Asn
Phe Thr Lys Asn Leu Lys 580 585 590 Val Leu Gln Lys Leu Met Met Asn
Asp Asn Asp Ile Ser Ser Ser Thr 595 600 605 Ser Arg Thr Met Glu Ser
Glu Ser Leu Arg Thr Leu Glu Phe Arg Gly 610 615 620 Asn His Leu Asp
Val Leu Trp Arg Glu Gly Asp Asn Arg Tyr Leu Gln 625 630 635 640 Leu
Phe Lys Asn Leu Leu Lys Leu Glu Glu Leu Asp Ile Ser Lys Asn 645 650
655 Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp Gly Met Pro Pro Asn
660 665 670 Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys Ser Phe
Ser Trp 675 680 685 Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu
Asp Leu Ser His 690 695 700 Asn Gln Leu Thr Thr Val Pro Glu Arg Leu
Ser Asn Cys Ser Arg Ser 705 710 715 720 Leu Lys Asn Leu Ile Leu Lys
Asn Asn Gln Ile Arg Ser Leu Thr Lys 725 730 735 Tyr Phe Leu Gln Asp
Ala Phe Gln Leu Arg Tyr Leu Asp Leu Ser Ser 740 745 750 Asn Lys Ile
Gln Met Ile Gln Lys Thr Ser Phe Pro Glu Asn Val Leu 755 760 765 Asn
Asn Leu Lys Met Leu Leu Leu His His Asn Arg Phe Leu Cys Thr 770 775
780 Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn His Thr Glu Val Thr
785 790 795 800 Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly Pro
Gly Ala His 805 810 815 Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr
Thr Cys Glu Leu Asp 820 825 830 Leu Thr Asn Leu Ile Leu Phe Ser Leu
Ser Ile Ser Val Ser Leu Phe 835 840 845 Leu Met Val Met Met Thr Ala
Ser His Leu Tyr Phe Trp Asp Val Trp 850 855 860 Tyr Ile Tyr His Phe
Cys Lys Ala Lys Ile Lys Gly Tyr Gln Arg Leu 865 870 875 880 Ile Ser
Pro Asp Cys Cys Tyr Asp Ala Phe Ile Val Tyr Asp Thr Lys 885 890 895
Asp Pro Ala Val Thr Glu Trp Val Leu Ala Glu Leu Val Ala Lys Leu 900
905 910 Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys Leu Glu Glu Arg
Asp 915 920 925 Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser Gln
Ser Ile Gln 930 935 940 Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp
Lys Tyr Ala Lys Thr 945 950 955 960 Glu Asn Phe Lys Ile Ala Phe Tyr
Leu Ser His Gln Arg Leu Met Asp 965 970 975 Glu Lys Val Asp Val Ile
Ile Leu Ile Phe Leu Glu Lys Pro Phe Gln 980 985 990 Lys Ser Lys Phe
Leu Gln Leu Arg Lys Arg Leu Cys Gly Ser Ser Val 995 1000 1005 Leu
Glu Trp Pro Thr Asn Pro Gln Ala His Pro Tyr Phe Trp Gln 1010 1015
1020 Cys Leu Lys Asn Ala Leu Ala Thr Asp Asn His Val Ala Tyr Ser
1025 1030 1035 Gln Val Phe Lys Glu Thr Val 1040 1045 <210>
SEQ ID NO 13 <211> LENGTH: 180 <212> TYPE: DNA
<213> ORGANISM: Mus musculus <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(177) <400>
SEQUENCE: 13 ctt gga aaa cct ctt cag aag tct aag ttt ctt cag ctc
agg aag aga 48 Leu Gly Lys Pro Leu Gln Lys Ser Lys Phe Leu Gln Leu
Arg Lys Arg 1 5 10 15 ctc tgc agg agc tct gtc ctt gag tgg cct gca
aat cca cag gct cac 96 Leu Cys Arg Ser Ser Val Leu Glu Trp Pro Ala
Asn Pro Gln Ala His 20 25 30 cca tac ttc tgg cag tgc ctg aaa aat
gcc ctg acc aca gac aat cat 144 Pro Tyr Phe Trp Gln Cys Leu Lys Asn
Ala Leu Thr Thr Asp Asn His 35 40 45 gtg gct tat agt caa atg ttc
aag gaa aca gtc tag 180 Val Ala Tyr Ser Gln Met Phe Lys Glu Thr Val
50 55 <210> SEQ ID NO 14 <211> LENGTH: 59 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
14 Leu Gly Lys Pro Leu Gln Lys Ser Lys Phe Leu Gln Leu Arg Lys Arg
1 5 10 15 Leu Cys Arg Ser Ser Val Leu Glu Trp Pro Ala Asn Pro Gln
Ala His 20 25 30 Pro Tyr Phe Trp Gln Cys Leu Lys Asn Ala Leu Thr
Thr Asp Asn His 35 40 45 Val Ala Tyr Ser Gln Met Phe Lys Glu Thr
Val 50 55 <210> SEQ ID NO 15 <211> LENGTH: 990
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (2)..(988) <400> SEQUENCE: 15 g aat tcc aga ctt ata
aac ttg aaa aat ctc tat ttg gcc tgg aac tgc 49 Asn Ser Arg Leu Ile
Asn Leu Lys Asn Leu Tyr Leu Ala Trp Asn Cys
1 5 10 15 tat ttt aac aaa gtt tgc gag aaa act aac ata gaa gat gga
gta ttt 97 Tyr Phe Asn Lys Val Cys Glu Lys Thr Asn Ile Glu Asp Gly
Val Phe 20 25 30 gaa acg ctg aca aat ttg gag ttg cta tca cta tct
ttc aat tct ctt 145 Glu Thr Leu Thr Asn Leu Glu Leu Leu Ser Leu Ser
Phe Asn Ser Leu 35 40 45 tca cat gtg cca ccc aaa ctg cca agc tcc
cta cgc aaa ctt ttt ctg 193 Ser His Val Pro Pro Lys Leu Pro Ser Ser
Leu Arg Lys Leu Phe Leu 50 55 60 agc aac acc cag atc aaa tac att
agt gaa gaa gat ttc aag gga ttg 241 Ser Asn Thr Gln Ile Lys Tyr Ile
Ser Glu Glu Asp Phe Lys Gly Leu 65 70 75 80 ata aat tta aca tta cta
gat tta agc ggg aac tgt ccg agg tgc ttc 289 Ile Asn Leu Thr Leu Leu
Asp Leu Ser Gly Asn Cys Pro Arg Cys Phe 85 90 95 aat gcc cca ttt
cca tgc gtg cct tgt gat ggt ggt gct tca att aat 337 Asn Ala Pro Phe
Pro Cys Val Pro Cys Asp Gly Gly Ala Ser Ile Asn 100 105 110 ata gat
cgt ttt gct ttt caa aac ttg acc caa ctt cga tac cta aac 385 Ile Asp
Arg Phe Ala Phe Gln Asn Leu Thr Gln Leu Arg Tyr Leu Asn 115 120 125
ctc tct agc act tcc ctc agg aag att aat gct gcc tgg ttt aaa aat 433
Leu Ser Ser Thr Ser Leu Arg Lys Ile Asn Ala Ala Trp Phe Lys Asn 130
135 140 atg cct cat ctg aag gtg ctg gat ctt gaa ttc aac tat tta gtg
gga 481 Met Pro His Leu Lys Val Leu Asp Leu Glu Phe Asn Tyr Leu Val
Gly 145 150 155 160 gaa ata gcc tct ggg gca ttt tta acg atg ctg ccc
cgc tta gaa ata 529 Glu Ile Ala Ser Gly Ala Phe Leu Thr Met Leu Pro
Arg Leu Glu Ile 165 170 175 ctt gac ttg tct ttt aac tat ata aag ggg
agt tat cca cag cat att 577 Leu Asp Leu Ser Phe Asn Tyr Ile Lys Gly
Ser Tyr Pro Gln His Ile 180 185 190 aat att tcc aga aac ttc tct aaa
ctt ttg tct cta cgg gca ttg cat 625 Asn Ile Ser Arg Asn Phe Ser Lys
Leu Leu Ser Leu Arg Ala Leu His 195 200 205 tta aga ggt tat gtg ttc
cag gaa ctc aga gaa gat gat ttc cag ccc 673 Leu Arg Gly Tyr Val Phe
Gln Glu Leu Arg Glu Asp Asp Phe Gln Pro 210 215 220 ctg atg cag ctt
cca aac tta tcg act atc aac ttg ggt att aat ttt 721 Leu Met Gln Leu
Pro Asn Leu Ser Thr Ile Asn Leu Gly Ile Asn Phe 225 230 235 240 att
aag caa atc gat ttc aaa ctt ttc caa aat ttc tcc aat ctg gaa 769 Ile
Lys Gln Ile Asp Phe Lys Leu Phe Gln Asn Phe Ser Asn Leu Glu 245 250
255 att att tac ttg tca gaa aac aga ata tca ccg ttg gta aaa gat acc
817 Ile Ile Tyr Leu Ser Glu Asn Arg Ile Ser Pro Leu Val Lys Asp Thr
260 265 270 cgg cag agt tat gca aat agt tcc tct ttt caa cgt cat atc
cgg aaa 865 Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln Arg His Ile
Arg Lys 275 280 285 cga cgc tca aca gat ttt gag ttt gac cca cat tcg
aac ttt tat cat 913 Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His Ser
Asn Phe Tyr His 290 295 300 ttc acc cgt cct tta ata aag cca caa tgt
gct gct tat gga aaa gcc 961 Phe Thr Arg Pro Leu Ile Lys Pro Gln Cys
Ala Ala Tyr Gly Lys Ala 305 310 315 320 tta gat tta agc ctc aac agt
att ttc tt 990 Leu Asp Leu Ser Leu Asn Ser Ile Phe 325 <210>
SEQ ID NO 16 <211> LENGTH: 329 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 16 Asn Ser
Arg Leu Ile Asn Leu Lys Asn Leu Tyr Leu Ala Trp Asn Cys 1 5 10 15
Tyr Phe Asn Lys Val Cys Glu Lys Thr Asn Ile Glu Asp Gly Val Phe 20
25 30 Glu Thr Leu Thr Asn Leu Glu Leu Leu Ser Leu Ser Phe Asn Ser
Leu 35 40 45 Ser His Val Pro Pro Lys Leu Pro Ser Ser Leu Arg Lys
Leu Phe Leu 50 55 60 Ser Asn Thr Gln Ile Lys Tyr Ile Ser Glu Glu
Asp Phe Lys Gly Leu 65 70 75 80 Ile Asn Leu Thr Leu Leu Asp Leu Ser
Gly Asn Cys Pro Arg Cys Phe 85 90 95 Asn Ala Pro Phe Pro Cys Val
Pro Cys Asp Gly Gly Ala Ser Ile Asn 100 105 110 Ile Asp Arg Phe Ala
Phe Gln Asn Leu Thr Gln Leu Arg Tyr Leu Asn 115 120 125 Leu Ser Ser
Thr Ser Leu Arg Lys Ile Asn Ala Ala Trp Phe Lys Asn 130 135 140 Met
Pro His Leu Lys Val Leu Asp Leu Glu Phe Asn Tyr Leu Val Gly 145 150
155 160 Glu Ile Ala Ser Gly Ala Phe Leu Thr Met Leu Pro Arg Leu Glu
Ile 165 170 175 Leu Asp Leu Ser Phe Asn Tyr Ile Lys Gly Ser Tyr Pro
Gln His Ile 180 185 190 Asn Ile Ser Arg Asn Phe Ser Lys Leu Leu Ser
Leu Arg Ala Leu His 195 200 205 Leu Arg Gly Tyr Val Phe Gln Glu Leu
Arg Glu Asp Asp Phe Gln Pro 210 215 220 Leu Met Gln Leu Pro Asn Leu
Ser Thr Ile Asn Leu Gly Ile Asn Phe 225 230 235 240 Ile Lys Gln Ile
Asp Phe Lys Leu Phe Gln Asn Phe Ser Asn Leu Glu 245 250 255 Ile Ile
Tyr Leu Ser Glu Asn Arg Ile Ser Pro Leu Val Lys Asp Thr 260 265 270
Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys 275
280 285 Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr
His 290 295 300 Phe Thr Arg Pro Leu Ile Lys Pro Gln Cys Ala Ala Tyr
Gly Lys Ala 305 310 315 320 Leu Asp Leu Ser Leu Asn Ser Ile Phe 325
<210> SEQ ID NO 17 <211> LENGTH: 1543 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(513)
<220> FEATURE: <221> NAME/KEY: modified_base
<222> LOCATION: (277)..(279) <223> OTHER INFORMATION:
Position 278 may be c or g, and this codon may encode Gly or Ala
<220> FEATURE: <221> NAME/KEY: modified_base
<222> LOCATION: (445)..(447) <223> OTHER INFORMATION:
Position 446 may be a or t, and this codon may encode Arg
<400> SEQUENCE: 17 cag tct ctt tcc aca tcc caa act ttc tat
gat gct tac att tct tat 48 Gln Ser Leu Ser Thr Ser Gln Thr Phe Tyr
Asp Ala Tyr Ile Ser Tyr 1 5 10 15 gac acc aaa gat gcc tct gtt act
gac tgg gtg ata aat gag ctg cgc 96 Asp Thr Lys Asp Ala Ser Val Thr
Asp Trp Val Ile Asn Glu Leu Arg 20 25 30 tac cac ctt gaa gag agc
cga gac aaa aac gtt ctc ctt tgt cta gag 144 Tyr His Leu Glu Glu Ser
Arg Asp Lys Asn Val Leu Leu Cys Leu Glu 35 40 45 gag agg gat tgg
gac ccg gga ttg gcc atc atc gac aac ctc atg cag 192 Glu Arg Asp Trp
Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln 50 55 60 agc atc
aac caa agc aag aaa aca gta ttt gtt tta acc aaa aaa tat 240 Ser Ile
Asn Gln Ser Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr 65 70 75 80
gca aaa agc tgg aac ttt aaa aca gct ttt tac ttg gsc ttg cag agg 288
Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr Leu Xaa Leu Gln Arg 85
90 95 cta atg ggt gag aac atg gat gtg att ata ttt atc ctg ctg gag
cca 336 Leu Met Gly Glu Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu
Pro 100 105 110 gtg tta cag cat tct ccg tat ttg agg cta cgg cag cgg
atc tgt aag 384 Val Leu Gln His Ser Pro Tyr Leu Arg Leu Arg Gln Arg
Ile Cys Lys 115 120 125 agc tcc atc ctc cag tgg cct gac aac ccg aag
gca gaa agg ttg ttt 432 Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys
Ala Glu Arg Leu Phe 130 135 140 tgg caa act ctg wga aat gtg gtc ttg
act gaa aat gat tca cgg tat 480 Trp Gln Thr Leu Xaa Asn Val Val Leu
Thr Glu Asn Asp Ser Arg Tyr 145 150 155 160 aac aat atg tat gtc gat
tcc att aag caa tac taactgacgt taagtcatga 533 Asn Asn Met Tyr Val
Asp Ser Ile Lys Gln Tyr 165 170 tttcgcgcca taataaagat gcaaaggaat
gacatttcgt attagttatc tattgctagg 593 taacaaatta tcccaaaaac
ttagtggttt aaaacaacac atttgctggc ccacagtttt 653 tgagggtcag
gagtccaggc ccagcataac tgggtcttct gcttcagggt gtctcagagg 713
ctgcaatgta ggtgttcacc agagacatag gcatcactgg ggtcacactc atgtggttgt
773 tttctggatt caattcctcc tgggctattg gccaaaggct atactcatgt
aagccatgcg 833 agcctatccc acaaggcagc ttgcttcatc agagctagca
aaaaagagag gttgctagca 893 agatgaagtc acaatctttt gtaatcgaat
caaaaaagtg atatctcatc actttggcca 953 tattctattt gttagaagta
aaccacaggt cccaccagct ccatgggagt gaccacctca 1013 gtccagggaa
aacagctgaa gaccaagatg gtgagctctg attgcttcag ttggtcatca 1073
actattttcc cttgactgct gtcctgggat ggccggctat cttgatggat agattgtgaa
1133 tatcaggagg ccagggatca ctgtggacca tcttagcagt tgacctaaca
catcttcttt 1193 tcaatatcta agaacttttg ccactgtgac taatggtcct
aatattaagc tgttgtttat 1253 atttatcata tatctatggc tacatggtta
tattatgctg tggttgcgtt cggttttatt 1313 tacagttgct tttacaaata
tttgctgtaa catttgactt ctaaggttta gatgccattt 1373 aagaactgag
atggatagct tttaaagcat cttttacttc ttaccatttt ttaaaagtat 1433
gcagctaaat tcgaagcttt tggtctatat tgttaattgc cattgctgta aatcttaaaa
1493
tgaatgaata aaaatgtttc attttaaaaa aaaaaaaaaa aaaaaaaaaa 1543
<210> SEQ ID NO 18 <211> LENGTH: 171 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (93)..(93)
<223> OTHER INFORMATION: Gly or Ala <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (149)..(149)
<223> OTHER INFORMATION: Arg or not present <400>
SEQUENCE: 18 Gln Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp Ala Tyr
Ile Ser Tyr 1 5 10 15 Asp Thr Lys Asp Ala Ser Val Thr Asp Trp Val
Ile Asn Glu Leu Arg 20 25 30 Tyr His Leu Glu Glu Ser Arg Asp Lys
Asn Val Leu Leu Cys Leu Glu 35 40 45 Glu Arg Asp Trp Asp Pro Gly
Leu Ala Ile Ile Asp Asn Leu Met Gln 50 55 60 Ser Ile Asn Gln Ser
Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr 65 70 75 80 Ala Lys Ser
Trp Asn Phe Lys Thr Ala Phe Tyr Leu Xaa Leu Gln Arg 85 90 95 Leu
Met Gly Glu Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu Pro 100 105
110 Val Leu Gln His Ser Pro Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys
115 120 125 Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys Ala Glu Arg
Leu Phe 130 135 140 Trp Gln Thr Leu Xaa Asn Val Val Leu Thr Glu Asn
Asp Ser Arg Tyr 145 150 155 160 Asn Asn Met Tyr Val Asp Ser Ile Lys
Gln Tyr 165 170 <210> SEQ ID NO 19 <211> LENGTH: 629
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(486) <220> FEATURE: <221> NAME/KEY:
modified_base <222> LOCATION: (142)..(144) <223> OTHER
INFORMATION: Position 144 may be c or t, and this codon encodes Ser
<400> SEQUENCE: 19 aat gaa ttg atc ccc aat cta gag aag gaa
gat ggt tct atc ttg att 48 Asn Glu Leu Ile Pro Asn Leu Glu Lys Glu
Asp Gly Ser Ile Leu Ile 1 5 10 15 tgc ctt tat gaa agc tac ttt gac
cct ggc aaa agc att agt gaa aat 96 Cys Leu Tyr Glu Ser Tyr Phe Asp
Pro Gly Lys Ser Ile Ser Glu Asn 20 25 30 att gta agc ttc att gag
aaa agc tat aag tcc atc ttt gtt ttg tcy 144 Ile Val Ser Phe Ile Glu
Lys Ser Tyr Lys Ser Ile Phe Val Leu Xaa 35 40 45 ccc aac ttt gtc
cag aat gag tgg tgc cat tat gaa ttc tac ttt gcc 192 Pro Asn Phe Val
Gln Asn Glu Trp Cys His Tyr Glu Phe Tyr Phe Ala 50 55 60 cac cac
aat ctc ttc cat gaa aat tct gat cay ata att ctt atc tta 240 His His
Asn Leu Phe His Glu Asn Ser Asp His Ile Ile Leu Ile Leu 65 70 75 80
ctg gaa ccc att cca ttc tat tgc att ccc acc agg tat cat aaa ctg 288
Leu Glu Pro Ile Pro Phe Tyr Cys Ile Pro Thr Arg Tyr His Lys Leu 85
90 95 gaa gct ctc ctg gaa aaa aaa gca tac ttg gaa tgg ccc aag gat
agg 336 Glu Ala Leu Leu Glu Lys Lys Ala Tyr Leu Glu Trp Pro Lys Asp
Arg 100 105 110 cgt aaa tgt ggg ctt ttc tgg gca aac ctt cga gct gct
gtt aat gtt 384 Arg Lys Cys Gly Leu Phe Trp Ala Asn Leu Arg Ala Ala
Val Asn Val 115 120 125 aat gta tta gcc acc aga gaa atg tat gaa ctg
cag aca ttc aca gag 432 Asn Val Leu Ala Thr Arg Glu Met Tyr Glu Leu
Gln Thr Phe Thr Glu 130 135 140 tta aat gaa gag tct cga ggt tct aca
atc tct ctg atg aga aca gac 480 Leu Asn Glu Glu Ser Arg Gly Ser Thr
Ile Ser Leu Met Arg Thr Asp 145 150 155 160 tgt cta taaaatccca
cagtccttgg gaagttgggg accacataca ctgttgggat 536 Cys Leu gtacattgat
acaaccttta tgatggcaat ttgacaatat ttattaaaat aaaaaatggt 596
tattcccttc aaaaaaaaaa aaaaaaaaaa aaa 629 <210> SEQ ID NO 20
<211> LENGTH: 162 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (48)..(48) <223> OTHER INFORMATION: Ser
<400> SEQUENCE: 20 Asn Glu Leu Ile Pro Asn Leu Glu Lys Glu
Asp Gly Ser Ile Leu Ile 1 5 10 15 Cys Leu Tyr Glu Ser Tyr Phe Asp
Pro Gly Lys Ser Ile Ser Glu Asn 20 25 30 Ile Val Ser Phe Ile Glu
Lys Ser Tyr Lys Ser Ile Phe Val Leu Xaa 35 40 45 Pro Asn Phe Val
Gln Asn Glu Trp Cys His Tyr Glu Phe Tyr Phe Ala 50 55 60 His His
Asn Leu Phe His Glu Asn Ser Asp His Ile Ile Leu Ile Leu 65 70 75 80
Leu Glu Pro Ile Pro Phe Tyr Cys Ile Pro Thr Arg Tyr His Lys Leu 85
90 95 Glu Ala Leu Leu Glu Lys Lys Ala Tyr Leu Glu Trp Pro Lys Asp
Arg 100 105 110 Arg Lys Cys Gly Leu Phe Trp Ala Asn Leu Arg Ala Ala
Val Asn Val 115 120 125 Asn Val Leu Ala Thr Arg Glu Met Tyr Glu Leu
Gln Thr Phe Thr Glu 130 135 140 Leu Asn Glu Glu Ser Arg Gly Ser Thr
Ile Ser Leu Met Arg Thr Asp 145 150 155 160 Cys Leu <210> SEQ
ID NO 21 <211> LENGTH: 427 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (1)..(426) <400> SEQUENCE: 21 aag
aac tcc aaa gaa aac ctc cag ttt cat gct ttt att tca tat agt 48 Lys
Asn Ser Lys Glu Asn Leu Gln Phe His Ala Phe Ile Ser Tyr Ser 1 5 10
15 gaa cat gat tct gcc tgg gtg aaa agt gaa ttg gta cct tac cta gaa
96 Glu His Asp Ser Ala Trp Val Lys Ser Glu Leu Val Pro Tyr Leu Glu
20 25 30 aaa gaa gat ata cag att tgt ctt cat gag aga aac ttt gtc
cct ggc 144 Lys Glu Asp Ile Gln Ile Cys Leu His Glu Arg Asn Phe Val
Pro Gly 35 40 45 aag agc att gtg gaa aat atc atc aac tgc att gag
aag agt tac aag 192 Lys Ser Ile Val Glu Asn Ile Ile Asn Cys Ile Glu
Lys Ser Tyr Lys 50 55 60 tcc atc ttt gtt ttg tct ccc aac ttt gtc
cag agt gag tgg tgc cat 240 Ser Ile Phe Val Leu Ser Pro Asn Phe Val
Gln Ser Glu Trp Cys His 65 70 75 80 tac gaa ctc tat ttt gcc cat cac
aat ctc ttt cat gaa gga tct aat 288 Tyr Glu Leu Tyr Phe Ala His His
Asn Leu Phe His Glu Gly Ser Asn 85 90 95 aac tta atc ctc atc tta
ctg gaa ccc att cca cag aac agc att ccc 336 Asn Leu Ile Leu Ile Leu
Leu Glu Pro Ile Pro Gln Asn Ser Ile Pro 100 105 110 aac aag tac cac
aag ctg aag gct ctc atg acg cag cgg act tat ttg 384 Asn Lys Tyr His
Lys Leu Lys Ala Leu Met Thr Gln Arg Thr Tyr Leu 115 120 125 cag tgg
ccc aag gag aaa agc aaa cgt ggg ctc ttt tgg gct a 427 Gln Trp Pro
Lys Glu Lys Ser Lys Arg Gly Leu Phe Trp Ala 130 135 140 <210>
SEQ ID NO 22 <211> LENGTH: 142 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 22 Lys Asn
Ser Lys Glu Asn Leu Gln Phe His Ala Phe Ile Ser Tyr Ser 1 5 10 15
Glu His Asp Ser Ala Trp Val Lys Ser Glu Leu Val Pro Tyr Leu Glu 20
25 30 Lys Glu Asp Ile Gln Ile Cys Leu His Glu Arg Asn Phe Val Pro
Gly 35 40 45 Lys Ser Ile Val Glu Asn Ile Ile Asn Cys Ile Glu Lys
Ser Tyr Lys 50 55 60 Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln
Ser Glu Trp Cys His 65 70 75 80 Tyr Glu Leu Tyr Phe Ala His His Asn
Leu Phe His Glu Gly Ser Asn 85 90 95 Asn Leu Ile Leu Ile Leu Leu
Glu Pro Ile Pro Gln Asn Ser Ile Pro 100 105 110 Asn Lys Tyr His Lys
Leu Lys Ala Leu Met Thr Gln Arg Thr Tyr Leu 115 120 125 Gln Trp Pro
Lys Glu Lys Ser Lys Arg Gly Leu Phe Trp Ala 130 135 140 <210>
SEQ ID NO 23 <211> LENGTH: 662 <212> TYPE: DNA
<213> ORGANISM: Homo sapiens <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(627) <220> FEATURE:
<221> NAME/KEY: modified_base
<222> LOCATION: (103)..(105) <223> OTHER INFORMATION:
Position 103 may be a or g, and this codon may encode Gly or Arg
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (313)..(315) <223> OTHER INFORMATION: Position 313
may be g or t, and this codon may encode Val or Phe <220>
FEATURE: <221> NAME/KEY: modified_base <222> LOCATION:
(316)..(318) <223> OTHER INFORMATION: Position 316 may be a,
c, t, or g, and this codon may encode Ile, Val, Leu, or Phe
<220> FEATURE: <221> NAME/KEY: modified_base
<222> LOCATION: (379)..(381) <223> OTHER INFORMATION:
Position 380 may be a, c, t, or g, and this codon may encode Lys,
Arg, Thr, or Met <220> FEATURE: <221> NAME/KEY:
modified_base <222> LOCATION: (406)..(408) <223> OTHER
INFORMATION: Positions 407 and 408 may be a, c, t, or g, and this
codon may encode Gln, His, Arg, Pro, or Leu <400> SEQUENCE:
23 gct tcc acc tgt gcc tgg cct ggc ttc cct ggc ggg ggc ggc aaa gtg
48 Ala Ser Thr Cys Ala Trp Pro Gly Phe Pro Gly Gly Gly Gly Lys Val
1 5 10 15 ggc gar atg agg atg ccc tgc cct acg atg cct tcg tgg tct
tcg aca 96 Gly Glu Met Arg Met Pro Cys Pro Thr Met Pro Ser Trp Ser
Ser Thr 20 25 30 aaa cgc rga gcg cag tgg cag act ggg tgt aca acg
agc ttc ggg ggc 144 Lys Arg Xaa Ala Gln Trp Gln Thr Gly Cys Thr Thr
Ser Phe Gly Gly 35 40 45 agc tgg agg agt gcc gtg ggc gct ggg cac
tcc gcc tgt gcc tgg agg 192 Ser Trp Arg Ser Ala Val Gly Ala Gly His
Ser Ala Cys Ala Trp Arg 50 55 60 aac gcg act ggc tgc ctg gca aaa
ccc tct ttg aga acc tgt ggg cct 240 Asn Ala Thr Gly Cys Leu Ala Lys
Pro Ser Leu Arg Thr Cys Gly Pro 65 70 75 80 cgg tct atg gca gcc gca
aga cgc tgt ttg tgc tgg ccc aca cgg acc 288 Arg Ser Met Ala Ala Ala
Arg Arg Cys Leu Cys Trp Pro Thr Arg Thr 85 90 95 ggg tca gtg gtc
tct tgc gcg cca ktt ntc ctg ctg gcc cag cag cgc 336 Gly Ser Val Val
Ser Cys Ala Pro Xaa Xaa Leu Leu Ala Gln Gln Arg 100 105 110 ctg ctg
gar gac cgc aag gac gtc gtg gtg ctg gtg atc cta ang cct 384 Leu Leu
Glu Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Xaa Pro 115 120 125
gac ggc caa gcc tcc cga cta cnn gat gcg ctg acc agc gcc tct gcc 432
Asp Gly Gln Ala Ser Arg Leu Xaa Asp Ala Leu Thr Ser Ala Ser Ala 130
135 140 gcc aga gtg tcc tcc tct ggc ccc acc agc cca gtg gtc gcg cag
ctt 480 Ala Arg Val Ser Ser Ser Gly Pro Thr Ser Pro Val Val Ala Gln
Leu 145 150 155 160 ctg agg cca gca tgc atg gcc ctg acc agg gac aac
cac cac ttc tat 528 Leu Arg Pro Ala Cys Met Ala Leu Thr Arg Asp Asn
His His Phe Tyr 165 170 175 aac cgg aac ttc tgc cag gga acc cac ggc
cga ata gcc gtg agc cgg 576 Asn Arg Asn Phe Cys Gln Gly Thr His Gly
Arg Ile Ala Val Ser Arg 180 185 190 aat cct gca cgg tgc cac ctc cac
aca cac cta aca tat gcc tgc ctg 624 Asn Pro Ala Arg Cys His Leu His
Thr His Leu Thr Tyr Ala Cys Leu 195 200 205 atc tgaccaacac
atgctcgcca ccctcaccac acacc 662 Ile <210> SEQ ID NO 24
<211> LENGTH: 209 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (35)..(35) <223> OTHER INFORMATION: Gly
or Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (105)..(105) <223> OTHER INFORMATION:
Val or Phe <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (106)..(106) <223> OTHER INFORMATION:
Ile, Val, Leu, or Phe <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (127)..(127) <223> OTHER
INFORMATION: Lys, Arg, Thr, or Met <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (136)..(136) <223>
OTHER INFORMATION: Gln, His, Arg, Pro, or Leu <400> SEQUENCE:
24 Ala Ser Thr Cys Ala Trp Pro Gly Phe Pro Gly Gly Gly Gly Lys Val
1 5 10 15 Gly Glu Met Arg Met Pro Cys Pro Thr Met Pro Ser Trp Ser
Ser Thr 20 25 30 Lys Arg Xaa Ala Gln Trp Gln Thr Gly Cys Thr Thr
Ser Phe Gly Gly 35 40 45 Ser Trp Arg Ser Ala Val Gly Ala Gly His
Ser Ala Cys Ala Trp Arg 50 55 60 Asn Ala Thr Gly Cys Leu Ala Lys
Pro Ser Leu Arg Thr Cys Gly Pro 65 70 75 80 Arg Ser Met Ala Ala Ala
Arg Arg Cys Leu Cys Trp Pro Thr Arg Thr 85 90 95 Gly Ser Val Val
Ser Cys Ala Pro Xaa Xaa Leu Leu Ala Gln Gln Arg 100 105 110 Leu Leu
Glu Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Xaa Pro 115 120 125
Asp Gly Gln Ala Ser Arg Leu Xaa Asp Ala Leu Thr Ser Ala Ser Ala 130
135 140 Ala Arg Val Ser Ser Ser Gly Pro Thr Ser Pro Val Val Ala Gln
Leu 145 150 155 160 Leu Arg Pro Ala Cys Met Ala Leu Thr Arg Asp Asn
His His Phe Tyr 165 170 175 Asn Arg Asn Phe Cys Gln Gly Thr His Gly
Arg Ile Ala Val Ser Arg 180 185 190 Asn Pro Ala Arg Cys His Leu His
Thr His Leu Thr Tyr Ala Cys Leu 195 200 205 Ile <210> SEQ ID
NO 25 <211> LENGTH: 4865 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (107)..(2617) <220> FEATURE:
<221> NAME/KEY: mat_peptide <222> LOCATION:
(173)..(2617) <400> SEQUENCE: 25 aaaatactcc cttgcctcaa
aaactgctcg gtcaaacggt gatagcaaac cacgcattca 60 cagggccact
gctgctcaca aaaccagtga ggatgatgcc aggatg atg tct gcc 115 Met Ser Ala
-20 tcg cgc ctg gct ggg act ctg atc cca gcc atg gcc ttc ctc tcc tgc
163 Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala Phe Leu Ser Cys
-15 -10 -5 gtg aga cca gaa agc tgg gag ccc tgc gtg gag gtt cct aat
att act 211 Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val Pro Asn
Ile Thr -1 1 5 10 15 tat caa tgc atg gag ctg aat ttc tac aaa atc
ccc gac aac ctc ccc 259 Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile
Pro Asp Asn Leu Pro 20 25 30 ttc tca acc aag aac ctg gac ctg agc
ttt aat ccc ctg agg cat tta 307 Phe Ser Thr Lys Asn Leu Asp Leu Ser
Phe Asn Pro Leu Arg His Leu 35 40 45 ggc agc tat agc ttc ttc agt
ttc cca gaa ctg cag gtg ctg gat tta 355 Gly Ser Tyr Ser Phe Phe Ser
Phe Pro Glu Leu Gln Val Leu Asp Leu 50 55 60 tcc agg tgt gaa atc
cag aca att gaa gat ggg gca tat cag agc cta 403 Ser Arg Cys Glu Ile
Gln Thr Ile Glu Asp Gly Ala Tyr Gln Ser Leu 65 70 75 agc cac ctc
tct acc tta ata ttg aca gga aac ccc atc cag agt tta 451 Ser His Leu
Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile Gln Ser Leu 80 85 90 95 gcc
ctg gga gcc ttt tct gga cta tca agt tta cag aag ctg gtg gct 499 Ala
Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu Gln Lys Leu Val Ala 100 105
110 gtg gag aca aat cta gca tct cta gag aac ttc ccc att gga cat ctc
547 Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile Gly His Leu
115 120 125 aaa act ttg aaa gaa ctt aat gtg gct cac aat ctt atc caa
tct ttc 595 Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn Leu Ile Gln
Ser Phe 130 135 140 aaa tta cct gag tat ttt tct aat ctg acc aat cta
gag cac ttg gac 643 Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn Leu
Glu His Leu Asp 145 150 155 ctt tcc agc aac aag att caa agt att tat
tgc aca gac ttg cgg gtt 691 Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr
Cys Thr Asp Leu Arg Val 160 165 170 175 cta cat caa atg ccc cta ctc
aat ctc tct tta gac ctg tcc ctg aac 739 Leu His Gln Met Pro Leu Leu
Asn Leu Ser Leu Asp Leu Ser Leu Asn 180 185 190 cct atg aac ttt atc
caa cca ggt gca ttt aaa gaa att agg ctt cat 787 Pro Met Asn Phe Ile
Gln Pro Gly Ala Phe Lys Glu Ile Arg Leu His 195 200 205 aag ctg act
tta aga aat aat ttt gat agt tta aat gta atg aaa act 835 Lys Leu Thr
Leu Arg Asn Asn Phe Asp Ser Leu Asn Val Met Lys Thr 210 215 220 tgt
att caa ggt ctg gct ggt tta gaa gtc cat cgt ttg gtt ctg gga 883 Cys
Ile Gln Gly Leu Ala Gly Leu Glu Val His Arg Leu Val Leu Gly 225 230
235 gaa ttt aga aat gaa gga aac ttg gaa aag ttt gac aaa tct gct cta
931 Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys Ser Ala Leu
240 245 250 255 gag ggc ctg tgc aat ttg acc att gaa gaa ttc cga tta
gca tac tta 979 Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe Arg Leu
Ala Tyr Leu 260 265 270 gac tac tac ctc gat gat att att gac tta ttt
aat tgt ttg aca aat 1027 Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu
Phe Asn Cys Leu Thr Asn 275 280 285
gtt tct tca ttt tcc ctg gtg agt gtg act att gaa agg gta aaa gac
1075 Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile Glu Arg Val Lys
Asp 290 295 300 ttt tct tat aat ttc gga tgg caa cat tta gaa tta gtt
aac tgt aaa 1123 Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu Leu
Val Asn Cys Lys 305 310 315 ttt gga cag ttt ccc aca ttg aaa ctc aaa
tct ctc aaa agg ctt act 1171 Phe Gly Gln Phe Pro Thr Leu Lys Leu
Lys Ser Leu Lys Arg Leu Thr 320 325 330 335 ttc act tcc aac aaa ggt
ggg aat gct ttt tca gaa gtt gat cta cca 1219 Phe Thr Ser Asn Lys
Gly Gly Asn Ala Phe Ser Glu Val Asp Leu Pro 340 345 350 agc ctt gag
ttt cta gat ctc agt aga aat ggc ttg agt ttc aaa ggt 1267 Ser Leu
Glu Phe Leu Asp Leu Ser Arg Asn Gly Leu Ser Phe Lys Gly 355 360 365
tgc tgt tct caa agt gat ttt ggg aca acc agc cta aag tat tta gat
1315 Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser Leu Lys Tyr Leu
Asp 370 375 380 ctg agc ttc aat ggt gtt att acc atg agt tca aac ttc
ttg ggc tta 1363 Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser Asn
Phe Leu Gly Leu 385 390 395 gaa caa cta gaa cat ctg gat ttc cag cat
tcc aat ttg aaa caa atg 1411 Glu Gln Leu Glu His Leu Asp Phe Gln
His Ser Asn Leu Lys Gln Met 400 405 410 415 agt gag ttt tca gta ttc
cta tca ctc aga aac ctc att tac ctt gac 1459 Ser Glu Phe Ser Val
Phe Leu Ser Leu Arg Asn Leu Ile Tyr Leu Asp 420 425 430 att tct cat
act cac acc aga gtt gct ttc aat ggc atc ttc aat ggc 1507 Ile Ser
His Thr His Thr Arg Val Ala Phe Asn Gly Ile Phe Asn Gly 435 440 445
ttg tcc agt ctc gaa gtc ttg aaa atg gct ggc aat tct ttc cag gaa
1555 Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly Asn Ser Phe Gln
Glu 450 455 460 aac ttc ctt cca gat atc ttc aca gag ctg aga aac ttg
acc ttc ctg 1603 Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg Asn
Leu Thr Phe Leu 465 470 475 gac ctc tct cag tgt caa ctg gag cag ttg
tct cca aca gca ttt aac 1651 Asp Leu Ser Gln Cys Gln Leu Glu Gln
Leu Ser Pro Thr Ala Phe Asn 480 485 490 495 tca ctc tcc agt ctt cag
gta cta aat atg agc cac aac aac ttc ttt 1699 Ser Leu Ser Ser Leu
Gln Val Leu Asn Met Ser His Asn Asn Phe Phe 500 505 510 tca ttg gat
acg ttt cct tat aag tgt ctg aac tcc ctc cag gtt ctt 1747 Ser Leu
Asp Thr Phe Pro Tyr Lys Cys Leu Asn Ser Leu Gln Val Leu 515 520 525
gat tac agt ctc aat cac ata atg act tcc aaa aaa cag gaa cta cag
1795 Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys Lys Gln Glu Leu
Gln 530 535 540 cat ttt cca agt agt cta gct ttc tta aat ctt act cag
aat gac ttt 1843 His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu Thr
Gln Asn Asp Phe 545 550 555 gct tgt act tgt gaa cac cag agt ttc ctg
caa tgg atc aag gac cag 1891 Ala Cys Thr Cys Glu His Gln Ser Phe
Leu Gln Trp Ile Lys Asp Gln 560 565 570 575 agg cag ctc ttg gtg gaa
gtt gaa cga atg gaa tgt gca aca cct tca 1939 Arg Gln Leu Leu Val
Glu Val Glu Arg Met Glu Cys Ala Thr Pro Ser 580 585 590 gat aag cag
ggc atg cct gtg ctg agt ttg aat atc acc tgt cag atg 1987 Asp Lys
Gln Gly Met Pro Val Leu Ser Leu Asn Ile Thr Cys Gln Met 595 600 605
aat aag acc atc att ggt gtg tcg gtc ctc agt gtg ctt gta gta tct
2035 Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser Val Leu Val Val
Ser 610 615 620 gtt gta gca gtt ctg gtc tat aag ttc tat ttt cac ctg
atg ctt ctt 2083 Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His
Leu Met Leu Leu 625 630 635 gct ggc tgc ata aag tat ggt aga ggt gaa
aac atc tat gat gcc ttt 2131 Ala Gly Cys Ile Lys Tyr Gly Arg Gly
Glu Asn Ile Tyr Asp Ala Phe 640 645 650 655 gtt atc tac tca agc cag
gat gag gac tgg gta agg aat gag cta gta 2179 Val Ile Tyr Ser Ser
Gln Asp Glu Asp Trp Val Arg Asn Glu Leu Val 660 665 670 aag aat tta
gaa gaa ggg gtg cct cca ttt cag ctc tgc ctt cac tac 2227 Lys Asn
Leu Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu His Tyr 675 680 685
aga gac ttt att ccc ggt gtg gcc att gct gcc aac atc atc cat gaa
2275 Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile His
Glu 690 695 700 ggt ttc cat aaa agc cga aag gtg att gtt gtg gtg tcc
cag cac ttc 2323 Gly Phe His Lys Ser Arg Lys Val Ile Val Val Val
Ser Gln His Phe 705 710 715 atc cag agc cgc tgg tgt atc ttt gaa tat
gag att gct cag acc tgg 2371 Ile Gln Ser Arg Trp Cys Ile Phe Glu
Tyr Glu Ile Ala Gln Thr Trp 720 725 730 735 cag ttt ctg agc agt cgt
gct ggt atc atc ttc att gtc ctg cag aag 2419 Gln Phe Leu Ser Ser
Arg Ala Gly Ile Ile Phe Ile Val Leu Gln Lys 740 745 750 gtg gag aag
acc ctg ctc agg cag cag gtg gag ctg tac cgc ctt ctc 2467 Val Glu
Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg Leu Leu 755 760 765
agc agg aac act tac ctg gag tgg gag gac agt gtc ctg ggg cgg cac
2515 Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly Arg
His 770 775 780 atc ttc tgg aga cga ctc aga aaa gcc ctg ctg gat ggt
aaa tca tgg 2563 Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp
Gly Lys Ser Trp 785 790 795 aat cca gaa gga aca gtg ggt aca gga tgc
aat tgg cag gaa gca aca 2611 Asn Pro Glu Gly Thr Val Gly Thr Gly
Cys Asn Trp Gln Glu Ala Thr 800 805 810 815 tct atc tgaagaggaa
aaataaaaac ctcctgaggc atttcttgcc cagctgggtc 2667 Ser Ile caacacttgt
tcagttaata agtattaaat gctgccacat gtcaggcctt atgctaaggg 2727
tgagtaattc catggtgcac tagatatgca gggctgctaa tctcaaggag cttccagtgc
2787 agagggaata aatgctagac taaaatacag agtcttccag gtgggcattt
caaccaactc 2847 agtcaaggaa cccatgacaa agaaagtcat ttcaactctt
acctcatcaa gttgaataaa 2907 gacagagaaa acagaaagag acattgttct
tttcctgagt cttttgaatg gaaattgtat 2967 tatgttatag ccatcataaa
accattttgg tagttttgac tgaactgggt gttcactttt 3027 tcctttttga
ttgaatacaa tttaaattct acttgatgac tgcagtcgtc aaggggctcc 3087
tgatgcaaga tgccccttcc attttaagtc tgtctcctta cagaggttaa agtctaatgg
3147 ctaattccta aggaaacctg attaacacat gctcacaacc atcctggtca
ttctcgaaca 3207 tgttctattt tttaactaat cacccctgat atatttttat
ttttatatat ccagttttca 3267 tttttttacg tcttgcctat aagctaatat
cataaataag gttgtttaag acgtgcttca 3327 aatatccata ttaaccacta
tttttcaagg aagtatggaa aagtacactc tgtcactttg 3387 tcactcgatg
tcattccaaa gttattgcct actaagtaat gactgtcatg aaagcagcat 3447
tgaaataatt tgtttaaagg gggcactctt ttaaacggga agaaaatttc cgcttcctgg
3507 tcttatcatg gacaatttgg gctagaggca ggaaggaagt gggatgacct
caggaagtca 3567 ccttttcttg attccagaaa catatgggct gataaacccg
gggtgacctc atgaaatgag 3627 ttgcagcaga agtttatttt tttcagaaca
agtgatgttt gatggacctc tgaatctctt 3687 tagggagaca cagatggctg
ggatccctcc cctgtaccct tctcactgcc aggagaacta 3747 cgtgtgaagg
tattcaaggc agggagtata cattgctgtt tcctgttggg caatgctcct 3807
tgaccacatt ttgggaagag tggatgttat cattgagaaa acaatgtgtc tggaattaat
3867 ggggttctta taaagaaggt tcccagaaaa gaatgttcat tccagcttct
tcaggaaaca 3927 ggaacattca aggaaaagga caatcaggat gtcatcaggg
aaatgaaaat aaaaaccaca 3987 atgagatatc accttatacc aggtagatgg
ctactataaa aaaatgaagt gtcatcaagg 4047 atatagagaa attggaaccc
ttcttcactg ctggagggaa tggaaaatgg tgtagccgtt 4107 atgaaaaaca
gtacggaggt ttctcaaaaa ttaaaaatag aactgctata tgatccagca 4167
atctcacttc tgtatatata cccaaaataa ttgaaatcag aatttcaaga aaatatttac
4227 actcccatgt tcattgtggc actcttcaca atcactgttt ccaaagttat
ggaaacaacc 4287 caaatttcca ttggaaaata aatggacaaa ggaaatgtgc
atataacgta caatggggat 4347 attattcagc ctaaaaaaag gggggatcct
gttatttatg acaacatgaa taaacccgga 4407 ggccattatg ctatgtaaaa
tgagcaagta acagaaagac aaatactgcc tgatttcatt 4467 tatatgaggt
tctaaaatag tcaaactcat agaagcagag aatagaacag tggttcctag 4527
ggaaaaggag gaagggagaa atgaggaaat agggagttgt ctaattggta taaaattata
4587 gtatgcaaga tgaattagct ctaaagatca gctgtatagc agagttcgta
taatgaacaa 4647 tactgtatta tgcacttaac attttgttaa gagggtacct
ctcatgttaa gtgttcttac 4707 catatacata tacacaagga agcttttgga
ggtgatggat atatttatta ccttgattgt 4767 ggtgatggtt tgacaggtat
gtgactatgt ctaaactcat caaattgtat acattaaata 4827 tatgcagttt
tataatatca aaaaaaaaaa aaaaaaaa 4865 <210> SEQ ID NO 26
<211> LENGTH: 837 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 26 Met Ser Ala Ser Arg Leu Ala
Gly Thr Leu Ile Pro Ala Met Ala Phe -20 -15 -10 Leu Ser Cys Val Arg
Pro Glu Ser Trp Glu Pro Cys Val Glu Val Pro -5 -1 1 5 Asn Ile Thr
Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile Pro Asp 10 15 20 25 Asn
Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn Pro Leu 30 35
40 Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu Gln Val
45 50 55 Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly
Ala Tyr 60 65 70 Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr
Gly Asn Pro Ile 75 80 85 90 Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly
Leu Ser Ser Leu Gln Lys 95 100 105 Leu Val Ala Val Glu Thr Asn Leu
Ala Ser Leu Glu Asn Phe Pro Ile 110 115 120 Gly His Leu Lys Thr Leu
Lys Glu Leu Asn Val Ala His Asn Leu Ile 125 130 135 Gln Ser Phe Lys
Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn Leu Glu 140 145 150
His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys Thr Asp 155
160 165 170 Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu
Asp Leu 175 180 185 Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala
Phe Lys Glu Ile 190 195 200 Arg Leu His Lys Leu Thr Leu Arg Asn Asn
Phe Asp Ser Leu Asn Val 205 210 215 Met Lys Thr Cys Ile Gln Gly Leu
Ala Gly Leu Glu Val His Arg Leu 220 225 230 235 Val Leu Gly Glu Phe
Arg Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys 240 245 250 Ser Ala Leu
Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe Arg Leu 255 260 265 Ala
Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe Asn Cys 270 275
280 Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile Glu Arg
285 290 295 Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu
Leu Val 300 305 310 315 Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys
Leu Lys Ser Leu Lys 320 325 330 Arg Leu Thr Phe Thr Ser Asn Lys Gly
Gly Asn Ala Phe Ser Glu Val 335 340 345 Asp Leu Pro Ser Leu Glu Phe
Leu Asp Leu Ser Arg Asn Gly Leu Ser 350 355 360 Phe Lys Gly Cys Cys
Ser Gln Ser Asp Phe Gly Thr Thr Ser Leu Lys 365 370 375 Tyr Leu Asp
Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser Asn Phe 380 385 390 395
Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser Asn Leu 400
405 410 Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn Leu
Ile 415 420 425 Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe
Asn Gly Ile 430 435 440 Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys
Met Ala Gly Asn Ser 445 450 455 Phe Gln Glu Asn Phe Leu Pro Asp Ile
Phe Thr Glu Leu Arg Asn Leu 460 465 470 475 Thr Phe Leu Asp Leu Ser
Gln Cys Gln Leu Glu Gln Leu Ser Pro Thr 480 485 490 Ala Phe Asn Ser
Leu Ser Ser Leu Gln Val Leu Asn Met Ser His Asn 495 500 505 Asn Phe
Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn Ser Leu 510 515 520
Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys Lys Gln 525
530 535 Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu Thr
Gln 540 545 550 555 Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe
Leu Gln Trp Ile 560 565 570 Lys Asp Gln Arg Gln Leu Leu Val Glu Val
Glu Arg Met Glu Cys Ala 575 580 585 Thr Pro Ser Asp Lys Gln Gly Met
Pro Val Leu Ser Leu Asn Ile Thr 590 595 600 Cys Gln Met Asn Lys Thr
Ile Ile Gly Val Ser Val Leu Ser Val Leu 605 610 615 Val Val Ser Val
Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu 620 625 630 635 Met
Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr 640 645
650 Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg Asn
655 660 665 Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln
Leu Cys 670 675 680 Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile
Ala Ala Asn Ile 685 690 695 Ile His Glu Gly Phe His Lys Ser Arg Lys
Val Ile Val Val Val Ser 700 705 710 715 Gln His Phe Ile Gln Ser Arg
Trp Cys Ile Phe Glu Tyr Glu Ile Ala 720 725 730 Gln Thr Trp Gln Phe
Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val 735 740 745 Leu Gln Lys
Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr 750 755 760 Arg
Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu 765 770
775 Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly
780 785 790 795 Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys
Asn Trp Gln 800 805 810 Glu Ala Thr Ser Ile 815 <210> SEQ ID
NO 27 <211> LENGTH: 300 <212> TYPE: DNA <213>
ORGANISM: Mus musculus <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (1)..(300) <400> SEQUENCE: 27 tcc
tat tct atg gaa aaa gat gct ttc cta ttt atg aga aat ttg aag 48 Ser
Tyr Ser Met Glu Lys Asp Ala Phe Leu Phe Met Arg Asn Leu Lys 1 5 10
15 gtt ctc tca cta aaa gat aac aat gtc aca gct gtc ccc acc act ttg
96 Val Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Thr Leu
20 25 30 cca cct aat tta cta gag ctc tat ctt tat aac aat atc att
aag aaa 144 Pro Pro Asn Leu Leu Glu Leu Tyr Leu Tyr Asn Asn Ile Ile
Lys Lys 35 40 45 atc caa gaa aat gat ttc aat aac ctc aat gag ttg
caa gtc ctt gac 192 Ile Gln Glu Asn Asp Phe Asn Asn Leu Asn Glu Leu
Gln Val Leu Asp 50 55 60 cta cgt gga aat tgc cct cga tgt cat aat
gtc cca tat ccg tgt aca 240 Leu Arg Gly Asn Cys Pro Arg Cys His Asn
Val Pro Tyr Pro Cys Thr 65 70 75 80 ccg tgt gaa aat aat tcc ccc tta
cag atc cat gac aat gct ttc aat 288 Pro Cys Glu Asn Asn Ser Pro Leu
Gln Ile His Asp Asn Ala Phe Asn 85 90 95 tca tcg aca gac 300 Ser
Ser Thr Asp 100 <210> SEQ ID NO 28 <211> LENGTH: 100
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 28 Ser Tyr Ser Met Glu Lys Asp Ala Phe Leu
Phe Met Arg Asn Leu Lys 1 5 10 15 Val Leu Ser Leu Lys Asp Asn Asn
Val Thr Ala Val Pro Thr Thr Leu 20 25 30 Pro Pro Asn Leu Leu Glu
Leu Tyr Leu Tyr Asn Asn Ile Ile Lys Lys 35 40 45 Ile Gln Glu Asn
Asp Phe Asn Asn Leu Asn Glu Leu Gln Val Leu Asp 50 55 60 Leu Arg
Gly Asn Cys Pro Arg Cys His Asn Val Pro Tyr Pro Cys Thr 65 70 75 80
Pro Cys Glu Asn Asn Ser Pro Leu Gln Ile His Asp Asn Ala Phe Asn 85
90 95 Ser Ser Thr Asp 100 <210> SEQ ID NO 29 <211>
LENGTH: 1756 <212> TYPE: DNA <213> ORGANISM: Mus
musculus <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(1182) <400> SEQUENCE: 29 tct cca gaa att ccc
tgg aat tcc ttg cct cct gag gtt ttt gag ggt 48 Ser Pro Glu Ile Pro
Trp Asn Ser Leu Pro Pro Glu Val Phe Glu Gly 1 5 10 15 atg ccg cca
aat cta aag aat ctc tcc ttg gcc aaa aat ggg ctc aaa 96 Met Pro Pro
Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys 20 25 30 tct
ttc ttt tgg gac aga ctc cag tta ctg aag cat ttg gaa att ttg 144 Ser
Phe Phe Trp Asp Arg Leu Gln Leu Leu Lys His Leu Glu Ile Leu 35 40
45 gac ctc agc cat aac cag ctg aca aaa gta cct gag aga ttg gcc aac
192 Asp Leu Ser His Asn Gln Leu Thr Lys Val Pro Glu Arg Leu Ala Asn
50 55 60 tgt tcc aaa agt ctc aca aca ctg att ctt aag cat aat caa
atc agg 240 Cys Ser Lys Ser Leu Thr Thr Leu Ile Leu Lys His Asn Gln
Ile Arg 65 70 75 80 caa ttg aca aaa tat ttt cta gaa gat gct ttg caa
ttg cgc tat cta 288 Gln Leu Thr Lys Tyr Phe Leu Glu Asp Ala Leu Gln
Leu Arg Tyr Leu 85 90 95 gac atc agt tca aat aaa atc cag gtc att
cag aag act agc ttc cca 336 Asp Ile Ser Ser Asn Lys Ile Gln Val Ile
Gln Lys Thr Ser Phe Pro 100 105 110 gaa aat gtc ctc aac aat ctg gag
atg ttg gtt tta cat cac aat cgc 384 Glu Asn Val Leu Asn Asn Leu Glu
Met Leu Val Leu His His Asn Arg 115 120 125 ttt ctt tgc aac tgt gat
gct gtg tgg ttt gtc tgg tgg gtt aac cat 432 Phe Leu Cys Asn Cys Asp
Ala Val Trp Phe Val Trp Trp Val Asn His 130 135 140 aca gat gtt act
att cca tac ctg gcc act gat gtg act tgt gta ggt 480 Thr Asp Val Thr
Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly 145 150 155 160 cca
gga gca cac aaa ggt caa agt gtc ata tcc ctt gat ctg tat acg 528 Pro
Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr 165 170
175 tgt gag tta gat ctc aca aac ctg att ctg ttc tca gtt tcc ata tca
576 Cys Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Val Ser Ile
Ser
180 185 190 tca gtc ctc ttt ctt atg gta gtt atg aca aca agt cac ctc
ttt ttc 624 Ser Val Leu Phe Leu Met Val Val Met Thr Thr Ser His Leu
Phe Phe 195 200 205 tgg gat atg tgg tac att tat tat ttt tgg aaa gca
aag ata aag ggg 672 Trp Asp Met Trp Tyr Ile Tyr Tyr Phe Trp Lys Ala
Lys Ile Lys Gly 210 215 220 tat cca gca tct gca atc cca tgg agt cct
tgt tat gat gct ttt att 720 Tyr Pro Ala Ser Ala Ile Pro Trp Ser Pro
Cys Tyr Asp Ala Phe Ile 225 230 235 240 gtg tat gac act aaa aac tca
gct gtg aca gaa tgg gtt ttg cag gag 768 Val Tyr Asp Thr Lys Asn Ser
Ala Val Thr Glu Trp Val Leu Gln Glu 245 250 255 ctg gtg gca aaa ttg
gaa gat cca aga gaa aaa cac ttc aat ttg tgt 816 Leu Val Ala Lys Leu
Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys 260 265 270 cta gaa gaa
aga gac tgg cta cca gga cag cca gtt cta gaa aac ctt 864 Leu Glu Glu
Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu 275 280 285 tcc
cag agc ata cag ctc agc aaa aag aca gtg ttt gtg atg aca cag 912 Ser
Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Gln 290 295
300 aaa tat gct aag act gag agt ttt aag atg gca ttt tat ttg tct cat
960 Lys Tyr Ala Lys Thr Glu Ser Phe Lys Met Ala Phe Tyr Leu Ser His
305 310 315 320 cag agg ctc ctg gat gaa aaa gtg gat gtg att atc ttg
ata ttc ttg 1008 Gln Arg Leu Leu Asp Glu Lys Val Asp Val Ile Ile
Leu Ile Phe Leu 325 330 335 gaa aga cct ctt cag aag tct aag ttt ctt
cag ctc agg aag aga ctc 1056 Glu Arg Pro Leu Gln Lys Ser Lys Phe
Leu Gln Leu Arg Lys Arg Leu 340 345 350 tgc agg agc tct gtc ctt gag
tgg cct gca aat cca cag gct cac cca 1104 Cys Arg Ser Ser Val Leu
Glu Trp Pro Ala Asn Pro Gln Ala His Pro 355 360 365 tac ttc tgg cag
tgc ctg aaa aat gcc ctg acc aca gac aat cat gtg 1152 Tyr Phe Trp
Gln Cys Leu Lys Asn Ala Leu Thr Thr Asp Asn His Val 370 375 380 gct
tat agt caa atg ttc aag gaa aca gtc tagctctctg aagaatgtca 1202 Ala
Tyr Ser Gln Met Phe Lys Glu Thr Val 385 390 ccacctagga catgccttgg
tacctgaagt tttcataaag gtttccataa atgaaggtct 1262 gaatttttcc
taacagttgt catggctcag attggtggga aatcatcaat atatggctaa 1322
gaaattaaga aggggagact gatagaagat aatttctttc ttcatgtgcc atgctcagtt
1382 aaatatttcc cctagctcaa atctgaaaaa ctgtgcctag gagacaacac
aaggctttga 1442 tttatctgca tacaattgat aagagccaca catctgccct
gaagaagtac tagtagtttt 1502 agtagtaggg taaaaattac acaagctttc
tctctctctg atactgaact gtaccagagt 1562 tcaatgaaat aaaagcccag
agaacttctc agtaaatggt ttcattatca tgtagtatcc 1622 accatgcaat
atgccacaaa accgctactg gtacaggaca gctggtagct gcttcaaggc 1682
ctcttatcat tttcttgggg cccatggagg ggttctctgg gaaaaaggga aggttttttt
1742 tggccatcca tgaa 1756 <210> SEQ ID NO 30 <211>
LENGTH: 394 <212> TYPE: PRT <213> ORGANISM: Mus
musculus <400> SEQUENCE: 30 Ser Pro Glu Ile Pro Trp Asn Ser
Leu Pro Pro Glu Val Phe Glu Gly 1 5 10 15 Met Pro Pro Asn Leu Lys
Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys 20 25 30 Ser Phe Phe Trp
Asp Arg Leu Gln Leu Leu Lys His Leu Glu Ile Leu 35 40 45 Asp Leu
Ser His Asn Gln Leu Thr Lys Val Pro Glu Arg Leu Ala Asn 50 55 60
Cys Ser Lys Ser Leu Thr Thr Leu Ile Leu Lys His Asn Gln Ile Arg 65
70 75 80 Gln Leu Thr Lys Tyr Phe Leu Glu Asp Ala Leu Gln Leu Arg
Tyr Leu 85 90 95 Asp Ile Ser Ser Asn Lys Ile Gln Val Ile Gln Lys
Thr Ser Phe Pro 100 105 110 Glu Asn Val Leu Asn Asn Leu Glu Met Leu
Val Leu His His Asn Arg 115 120 125 Phe Leu Cys Asn Cys Asp Ala Val
Trp Phe Val Trp Trp Val Asn His 130 135 140 Thr Asp Val Thr Ile Pro
Tyr Leu Ala Thr Asp Val Thr Cys Val Gly 145 150 155 160 Pro Gly Ala
His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr 165 170 175 Cys
Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Val Ser Ile Ser 180 185
190 Ser Val Leu Phe Leu Met Val Val Met Thr Thr Ser His Leu Phe Phe
195 200 205 Trp Asp Met Trp Tyr Ile Tyr Tyr Phe Trp Lys Ala Lys Ile
Lys Gly 210 215 220 Tyr Pro Ala Ser Ala Ile Pro Trp Ser Pro Cys Tyr
Asp Ala Phe Ile 225 230 235 240 Val Tyr Asp Thr Lys Asn Ser Ala Val
Thr Glu Trp Val Leu Gln Glu 245 250 255 Leu Val Ala Lys Leu Glu Asp
Pro Arg Glu Lys His Phe Asn Leu Cys 260 265 270 Leu Glu Glu Arg Asp
Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu 275 280 285 Ser Gln Ser
Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Gln 290 295 300 Lys
Tyr Ala Lys Thr Glu Ser Phe Lys Met Ala Phe Tyr Leu Ser His 305 310
315 320 Gln Arg Leu Leu Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe
Leu 325 330 335 Glu Arg Pro Leu Gln Lys Ser Lys Phe Leu Gln Leu Arg
Lys Arg Leu 340 345 350 Cys Arg Ser Ser Val Leu Glu Trp Pro Ala Asn
Pro Gln Ala His Pro 355 360 365 Tyr Phe Trp Gln Cys Leu Lys Asn Ala
Leu Thr Thr Asp Asn His Val 370 375 380 Ala Tyr Ser Gln Met Phe Lys
Glu Thr Val 385 390 <210> SEQ ID NO 31 <211> LENGTH:
999 <212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (2)..(847) <400> SEQUENCE: 31 c tcc gat gcc aag att
cgg cac cag gca tat tca gag gtc atg atg gtt 49 Ser Asp Ala Lys Ile
Arg His Gln Ala Tyr Ser Glu Val Met Met Val 1 5 10 15 gga tgg tca
gat tca tac acc tgt gaa tac cct tta aac cta agg gga 97 Gly Trp Ser
Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg Gly 20 25 30 act
agg tta aaa gac gtt cat ctc cac gaa tta tct tgc aac aca gct 145 Thr
Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr Ala 35 40
45 ctg ttg att gtc acc att gtg gtt att atg cta gtt ctg ggg ttg gct
193 Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu Ala
50 55 60 gtg gcc ttc tgc tgt ctc cac ttt gat ctg ccc tgg tat ctc
agg atg 241 Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu
Arg Met 65 70 75 80 cta ggt caa tgc aca caa aca tgg cac agg gtt agg
aaa aca acc caa 289 Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg
Lys Thr Thr Gln 85 90 95 gaa caa ctc aag aga aat gtc cga ttc cac
gca ttt att tca tac agt 337 Glu Gln Leu Lys Arg Asn Val Arg Phe His
Ala Phe Ile Ser Tyr Ser 100 105 110 gaa cat gat tct ctg tgg gtg aag
aat gaa ttg atc ccc aat cta gag 385 Glu His Asp Ser Leu Trp Val Lys
Asn Glu Leu Ile Pro Asn Leu Glu 115 120 125 aag gaa gat ggt tct atc
ttg att tgc ctt tat gaa agc tac ttt gac 433 Lys Glu Asp Gly Ser Ile
Leu Ile Cys Leu Tyr Glu Ser Tyr Phe Asp 130 135 140 cct ggc aaa agc
att agt gaa aat att gta agc ttc att gag aaa agc 481 Pro Gly Lys Ser
Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys Ser 145 150 155 160 tat
aag tcc atc ttt gtt ttg tct ccc aac ttt gtc cag aat gag tgg 529 Tyr
Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu Trp 165 170
175 tgc cat tat gaa ttc tac ttt gcc cac cac aat ctc ttc cat gaa aat
577 Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu Asn
180 185 190 tct gat cac ata att ctt atc tta ctg gaa ccc att cca ttc
tat tgc 625 Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe
Tyr Cys 195 200 205 att ccc acc agg tat cat aaa ctg gaa gct ctc ctg
gaa aaa aaa gca 673 Ile Pro Thr Arg Tyr His Lys Leu Glu Ala Leu Leu
Glu Lys Lys Ala 210 215 220 tac ttg gaa tgg ccc aag gat agg cgt aaa
tgt ggg ctt ttc tgg gca 721 Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys
Cys Gly Leu Phe Trp Ala 225 230 235 240 aac ctt cga gct gct gtt aat
gtt aat gta tta gcc acc aga gaa atg 769 Asn Leu Arg Ala Ala Val Asn
Val Asn Val Leu Ala Thr Arg Glu Met 245 250 255 tat gaa ctg cag aca
ttc aca gag tta aat gaa gag tct cga ggt tct 817 Tyr Glu Leu Gln Thr
Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly Ser 260 265 270 aca atc tct
ctg atg aga aca gac tgt cta taaaatccca cagtccttgg 867 Thr Ile Ser
Leu Met Arg Thr Asp Cys Leu 275 280 gaagttgggg accacataca
ctgttgggat gtacattgat acaaccttta tgatggcaat 927 ttgacaatat
ttattaaaat aaaaaatggt tattcccttc aaaaaaaaaa aaaaaaaaaa 987
aaaaaaaaaa aa 999 <210> SEQ ID NO 32 <211> LENGTH: 282
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 32 Ser Asp Ala Lys Ile Arg His Gln Ala Tyr
Ser Glu Val Met Met Val 1 5 10 15 Gly Trp Ser Asp Ser Tyr Thr Cys
Glu Tyr Pro Leu Asn Leu Arg Gly 20 25 30 Thr Arg Leu Lys Asp Val
His Leu His Glu Leu Ser Cys Asn Thr Ala 35 40 45 Leu Leu Ile Val
Thr Ile Val Val Ile Met Leu Val Leu Gly Leu Ala 50 55 60 Val Ala
Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg Met 65 70 75 80
Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr Gln 85
90 95 Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr
Ser 100 105 110 Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro
Asn Leu Glu 115 120 125 Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr
Glu Ser Tyr Phe Asp 130 135 140 Pro Gly Lys Ser Ile Ser Glu Asn Ile
Val Ser Phe Ile Glu Lys Ser 145 150 155 160 Tyr Lys Ser Ile Phe Val
Leu Ser Pro Asn Phe Val Gln Asn Glu Trp 165 170 175 Cys His Tyr Glu
Phe Tyr Phe Ala His His Asn Leu Phe His Glu Asn 180 185 190 Ser Asp
His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr Cys 195 200 205
Ile Pro Thr Arg Tyr His Lys Leu Glu Ala Leu Leu Glu Lys Lys Ala 210
215 220 Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp
Ala 225 230 235 240 Asn Leu Arg Ala Ala Val Asn Val Asn Val Leu Ala
Thr Arg Glu Met 245 250 255 Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn
Glu Glu Ser Arg Gly Ser 260 265 270 Thr Ile Ser Leu Met Arg Thr Asp
Cys Leu 275 280 <210> SEQ ID NO 33 <211> LENGTH: 1173
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(1008) <400> SEQUENCE: 33 ctg cct gct ggc acc
cgg ctc cgg agg ctg gat gtc agc tgc aac agc 48 Leu Pro Ala Gly Thr
Arg Leu Arg Arg Leu Asp Val Ser Cys Asn Ser 1 5 10 15 atc agc ttc
gtg gcc ccc ggc ttc ttt tcc aag gcc aag gag ctg cga 96 Ile Ser Phe
Val Ala Pro Gly Phe Phe Ser Lys Ala Lys Glu Leu Arg 20 25 30 gag
ctc aac ctt agc gcc aac gcc ctc aag aca gtg gac cac tcc tgg 144 Glu
Leu Asn Leu Ser Ala Asn Ala Leu Lys Thr Val Asp His Ser Trp 35 40
45 ttt ggg ccc ctg gcg agt gcc ctg caa ata cta gat gta agc gcc aac
192 Phe Gly Pro Leu Ala Ser Ala Leu Gln Ile Leu Asp Val Ser Ala Asn
50 55 60 cct ctg cac tgc gcc tgt ggg gcg gcc ttt atg gac ttc ctg
ctg gag 240 Pro Leu His Cys Ala Cys Gly Ala Ala Phe Met Asp Phe Leu
Leu Glu 65 70 75 80 gtg cag gct gcc gtg ccc ggt ctg ccc agc cgg gtg
aag tgt ggc agt 288 Val Gln Ala Ala Val Pro Gly Leu Pro Ser Arg Val
Lys Cys Gly Ser 85 90 95 ccg ggc cag ctc cag ggc ctc agc atc ttt
gca cag gac ctg cgc ctc 336 Pro Gly Gln Leu Gln Gly Leu Ser Ile Phe
Ala Gln Asp Leu Arg Leu 100 105 110 tgc ctg gat gag gcc ctc tcc tgg
gac tgt ttc gcc ctc tcg ctg ctg 384 Cys Leu Asp Glu Ala Leu Ser Trp
Asp Cys Phe Ala Leu Ser Leu Leu 115 120 125 gct gtg gct ctg ggc ctg
ggt gtg ccc atg ctg cat cac ctc tgt ggc 432 Ala Val Ala Leu Gly Leu
Gly Val Pro Met Leu His His Leu Cys Gly 130 135 140 tgg gac ctc tgg
tac tgc ttc cac ctg tgc ctg gcc tgg ctt ccc tgg 480 Trp Asp Leu Trp
Tyr Cys Phe His Leu Cys Leu Ala Trp Leu Pro Trp 145 150 155 160 cgg
ggg cgg caa agt ggg cga gat gag gat gcc ctg ccc tac gat gcc 528 Arg
Gly Arg Gln Ser Gly Arg Asp Glu Asp Ala Leu Pro Tyr Asp Ala 165 170
175 ttc gtg gtc ttc gac aaa acg cag agc gca gtg gca gac tgg gtg tac
576 Phe Val Val Phe Asp Lys Thr Gln Ser Ala Val Ala Asp Trp Val Tyr
180 185 190 aac gag ctt cgg ggg cag ctg gag gag tgc cgt ggg cgc tgg
gca ctc 624 Asn Glu Leu Arg Gly Gln Leu Glu Glu Cys Arg Gly Arg Trp
Ala Leu 195 200 205 cgc ctg tgc ctg gag gaa cgc gac tgg ctg cct ggc
aaa acc ctc ttt 672 Arg Leu Cys Leu Glu Glu Arg Asp Trp Leu Pro Gly
Lys Thr Leu Phe 210 215 220 gag aac ctg tgg gcc tcg gtc tat ggc agc
cgc aag acg ctg ttt gtg 720 Glu Asn Leu Trp Ala Ser Val Tyr Gly Ser
Arg Lys Thr Leu Phe Val 225 230 235 240 ctg gcc cac acg gac cgg gtc
agt ggt ctc ttg cgc gcc agc ttc ctg 768 Leu Ala His Thr Asp Arg Val
Ser Gly Leu Leu Arg Ala Ser Phe Leu 245 250 255 ctg gcc cag cag cgc
ctg ctg gag gac cgc aag gac gtc gtg gtg ctg 816 Leu Ala Gln Gln Arg
Leu Leu Glu Asp Arg Lys Asp Val Val Val Leu 260 265 270 gtg atc ctg
agc cct gac ggc cgc cgc tcc cgc tac gag cgg ctg cgc 864 Val Ile Leu
Ser Pro Asp Gly Arg Arg Ser Arg Tyr Glu Arg Leu Arg 275 280 285 cag
cgc ctc tgc cgc cag agt gtc ctc ctc tgg ccc cac cag ccc agt 912 Gln
Arg Leu Cys Arg Gln Ser Val Leu Leu Trp Pro His Gln Pro Ser 290 295
300 ggt cag cgc agc ttc tgg gcc cag ctg ggc atg gcc ctg acc agg gac
960 Gly Gln Arg Ser Phe Trp Ala Gln Leu Gly Met Ala Leu Thr Arg Asp
305 310 315 320 aac cac cac ttc tat aac cgg aac ttc tgc cag gga ccc
acg gcc gaa 1008 Asn His His Phe Tyr Asn Arg Asn Phe Cys Gln Gly
Pro Thr Ala Glu 325 330 335 tagccgtgag ccggaatcct gcacggtgcc
acctccacac tcacctcacc tctgcctgcc 1068 tggtctgacc ctcccctgct
cgcctccctc accccacacc tgacacagag caggcactca 1128 ataaatgcta
ccgaaggcta aaaaaaaaaa aaaaaaaaaa aacca 1173 <210> SEQ ID NO
34 <211> LENGTH: 336 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 34 Leu Pro Ala Gly Thr
Arg Leu Arg Arg Leu Asp Val Ser Cys Asn Ser 1 5 10 15 Ile Ser Phe
Val Ala Pro Gly Phe Phe Ser Lys Ala Lys Glu Leu Arg 20 25 30 Glu
Leu Asn Leu Ser Ala Asn Ala Leu Lys Thr Val Asp His Ser Trp 35 40
45 Phe Gly Pro Leu Ala Ser Ala Leu Gln Ile Leu Asp Val Ser Ala Asn
50 55 60 Pro Leu His Cys Ala Cys Gly Ala Ala Phe Met Asp Phe Leu
Leu Glu 65 70 75 80 Val Gln Ala Ala Val Pro Gly Leu Pro Ser Arg Val
Lys Cys Gly Ser 85 90 95 Pro Gly Gln Leu Gln Gly Leu Ser Ile Phe
Ala Gln Asp Leu Arg Leu 100 105 110 Cys Leu Asp Glu Ala Leu Ser Trp
Asp Cys Phe Ala Leu Ser Leu Leu 115 120 125 Ala Val Ala Leu Gly Leu
Gly Val Pro Met Leu His His Leu Cys Gly 130 135 140 Trp Asp Leu Trp
Tyr Cys Phe His Leu Cys Leu Ala Trp Leu Pro Trp 145 150 155 160 Arg
Gly Arg Gln Ser Gly Arg Asp Glu Asp Ala Leu Pro Tyr Asp Ala 165 170
175 Phe Val Val Phe Asp Lys Thr Gln Ser Ala Val Ala Asp Trp Val Tyr
180 185 190 Asn Glu Leu Arg Gly Gln Leu Glu Glu Cys Arg Gly Arg Trp
Ala Leu 195 200 205 Arg Leu Cys Leu Glu Glu Arg Asp Trp Leu Pro Gly
Lys Thr Leu Phe 210 215 220 Glu Asn Leu Trp Ala Ser Val Tyr Gly Ser
Arg Lys Thr Leu Phe Val 225 230 235 240 Leu Ala His Thr Asp Arg Val
Ser Gly Leu Leu Arg Ala Ser Phe Leu 245 250 255 Leu Ala Gln Gln Arg
Leu Leu Glu Asp Arg Lys Asp Val Val Val Leu 260 265 270 Val Ile Leu
Ser Pro Asp Gly Arg Arg Ser Arg Tyr Glu Arg Leu Arg 275 280 285 Gln
Arg Leu Cys Arg Gln Ser Val Leu Leu Trp Pro His Gln Pro Ser 290 295
300 Gly Gln Arg Ser Phe Trp Ala Gln Leu Gly Met Ala Leu Thr Arg Asp
305 310 315 320 Asn His His Phe Tyr Asn Arg Asn Phe Cys Gln Gly Pro
Thr Ala Glu 325 330 335 <210> SEQ ID NO 35 <211>
LENGTH: 497 <212> TYPE: DNA <213> ORGANISM: Mus
musculus <400> SEQUENCE: 35 tggcccacac ggaccgcgtc agtggcctcc
tgcgcaccag cttcctgctg gctcagcagc 60 gcctgttgga agaccgcaag
gacgtggtgg tgttggtgat cctgcgtccg gatgccccac 120 cgtcccgcta
tgtgcgactg cgccagcgtc tctgccgcca gagtgtgctc ttctggcccc 180
agcgacccaa cgggcagggg ggcttctggg cccagctgag tacagccctg actagggaca
240 accgccactt ctataaccag aacttctgcc ggggacctac agcagaatag
ctcagagcaa 300 cagctggaaa cagctgcatc ttcatgtctg gttcccgagt
tgctctgcct gccttgctct 360 gtcttactac accgctattt ggcaagtgcg
caatatatgc taccaagcca ccaggcccac 420
ggagcaaagg ttggctgtaa agggtagttt tcttcccatg catctttcag gagagtgaag
480 atagacacca aacccac 497 <210> SEQ ID NO 36 <211>
LENGTH: 3099 <212> TYPE: DNA <213> ORGANISM: Homo
sapiens <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(3096) <220> FEATURE: <221> NAME/KEY:
mat_peptide <222> LOCATION: (52)..(3096) <220> FEATURE:
<221> NAME/KEY: modified_base <222> LOCATION:
(2224..(2226) <223> OTHER INFORMATION: Position 2226 may be a
or c, and this codon encodes Ile <400> SEQUENCE: 36 atg ctg
acc tgc att ttc ctg cta ata tct ggt tcc tgt gag tta tgc 48 Met Leu
Thr Cys Ile Phe Leu Leu Ile Ser Gly Ser Cys Glu Leu Cys -15 -10 -5
-1 1 gcc gaa gaa aat ttt tct aga agc tat cct tgt gat gag aaa aag
caa 96 Ala Glu Glu Asn Phe Ser Arg Ser Tyr Pro Cys Asp Glu Lys Lys
Gln 5 10 15 aat gac tca gtt att gca gag tgc agc aat cgt cga cta cag
gaa gtt 144 Asn Asp Ser Val Ile Ala Glu Cys Ser Asn Arg Arg Leu Gln
Glu Val 20 25 30 ccc caa acg gtg ggc aaa tat gtg aca gaa cta gac
ctg tct gat aat 192 Pro Gln Thr Val Gly Lys Tyr Val Thr Glu Leu Asp
Leu Ser Asp Asn 35 40 45 ttc atc aca cac ata acg aat gaa tca ttt
caa ggg ctg caa aat ctc 240 Phe Ile Thr His Ile Thr Asn Glu Ser Phe
Gln Gly Leu Gln Asn Leu 50 55 60 act aaa ata aat cta aac cac aac
ccc aat gta cag cac cag aac gga 288 Thr Lys Ile Asn Leu Asn His Asn
Pro Asn Val Gln His Gln Asn Gly 65 70 75 80 aat ccc ggt ata caa tca
aat ggc ttg aat atc aca gac ggg gca ttc 336 Asn Pro Gly Ile Gln Ser
Asn Gly Leu Asn Ile Thr Asp Gly Ala Phe 85 90 95 ctc aac cta aaa
aac cta agg gag tta ctg ctt gaa gac aac cag tta 384 Leu Asn Leu Lys
Asn Leu Arg Glu Leu Leu Leu Glu Asp Asn Gln Leu 100 105 110 ccc caa
ata ccc tct ggt ttg cca gag tct ttg aca gaa ctt agt cta 432 Pro Gln
Ile Pro Ser Gly Leu Pro Glu Ser Leu Thr Glu Leu Ser Leu 115 120 125
att caa aac aat ata tac aac ata act aaa gag ggc att tca aga ctt 480
Ile Gln Asn Asn Ile Tyr Asn Ile Thr Lys Glu Gly Ile Ser Arg Leu 130
135 140 ata aac ttg aaa aat ctc tat ttg gcc tgg aac tgc tat ttt aac
aaa 528 Ile Asn Leu Lys Asn Leu Tyr Leu Ala Trp Asn Cys Tyr Phe Asn
Lys 145 150 155 160 gtt tgc gag aaa act aac ata gaa gat gga gta ttt
gaa acg ctg aca 576 Val Cys Glu Lys Thr Asn Ile Glu Asp Gly Val Phe
Glu Thr Leu Thr 165 170 175 aat ttg gag ttg cta tca cta tct ttc aat
tct ctt tca cat gtg cca 624 Asn Leu Glu Leu Leu Ser Leu Ser Phe Asn
Ser Leu Ser His Val Pro 180 185 190 ccc aaa ctg cca agc tcc cta cgc
aaa ctt ttt ctg agc aac acc cag 672 Pro Lys Leu Pro Ser Ser Leu Arg
Lys Leu Phe Leu Ser Asn Thr Gln 195 200 205 atc aaa tac att agt gaa
gaa gat ttc aag gga ttg ata aat tta aca 720 Ile Lys Tyr Ile Ser Glu
Glu Asp Phe Lys Gly Leu Ile Asn Leu Thr 210 215 220 tta cta gat tta
agc ggg aac tgt ccg agg tgc ttc aat gcc cca ttt 768 Leu Leu Asp Leu
Ser Gly Asn Cys Pro Arg Cys Phe Asn Ala Pro Phe 225 230 235 240 cca
tgc gtg cct tgt gat ggt ggt gct tca att aat ata gat cgt ttt 816 Pro
Cys Val Pro Cys Asp Gly Gly Ala Ser Ile Asn Ile Asp Arg Phe 245 250
255 gct ttt caa aac ttg acc caa ctt cga tac cta aac ctc tct agc act
864 Ala Phe Gln Asn Leu Thr Gln Leu Arg Tyr Leu Asn Leu Ser Ser Thr
260 265 270 tcc ctc agg aag att aat gct gcc tgg ttt aaa aat atg cct
cat ctg 912 Ser Leu Arg Lys Ile Asn Ala Ala Trp Phe Lys Asn Met Pro
His Leu 275 280 285 aag gtg ctg gat ctt gaa ttc aac tat tta gtg gga
gaa ata gcc tct 960 Lys Val Leu Asp Leu Glu Phe Asn Tyr Leu Val Gly
Glu Ile Ala Ser 290 295 300 ggg gca ttt tta acg atg ctg ccc cgc tta
gaa ata ctt gac ttg tct 1008 Gly Ala Phe Leu Thr Met Leu Pro Arg
Leu Glu Ile Leu Asp Leu Ser 305 310 315 320 ttt aac tat ata aag ggg
agt tat cca cag cat att aat att tcc aga 1056 Phe Asn Tyr Ile Lys
Gly Ser Tyr Pro Gln His Ile Asn Ile Ser Arg 325 330 335 aac ttc tct
aaa ctt ttg tct cta cgg gca ttg cat tta aga ggt tat 1104 Asn Phe
Ser Lys Leu Leu Ser Leu Arg Ala Leu His Leu Arg Gly Tyr 340 345 350
gtg ttc cag gaa ctc aga gaa gat gat ttc cag ccc ctg atg cag ctt
1152 Val Phe Gln Glu Leu Arg Glu Asp Asp Phe Gln Pro Leu Met Gln
Leu 355 360 365 cca aac tta tcg act atc aac ttg ggt att aat ttt att
aag caa atc 1200 Pro Asn Leu Ser Thr Ile Asn Leu Gly Ile Asn Phe
Ile Lys Gln Ile 370 375 380 gat ttc aaa ctt ttc caa aat ttc tcc aat
ctg gaa att att tac ttg 1248 Asp Phe Lys Leu Phe Gln Asn Phe Ser
Asn Leu Glu Ile Ile Tyr Leu 385 390 395 400 tca gaa aac aga ata tca
ccg ttg gta aaa gat acc cgg cag agt tat 1296 Ser Glu Asn Arg Ile
Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr 405 410 415 gca aat agt
tcc tct ttt caa cgt cat atc cgg aaa cga cgc tca aca 1344 Ala Asn
Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr 420 425 430
gat ttt gag ttt gac cca cat tcg aac ttt tat cat ttc acc cgt cct
1392 Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg
Pro 435 440 445 tta ata aag cca caa tgt gct gct tat gga aaa gcc tta
gat tta agc 1440 Leu Ile Lys Pro Gln Cys Ala Ala Tyr Gly Lys Ala
Leu Asp Leu Ser 450 455 460 ctc aac agt att ttc ttc att ggg cca aac
caa ttt gaa aat ctt cct 1488 Leu Asn Ser Ile Phe Phe Ile Gly Pro
Asn Gln Phe Glu Asn Leu Pro 465 470 475 480 gac att gcc tgt tta aat
ctg tct gca aat agc aat gct caa gtg tta 1536 Asp Ile Ala Cys Leu
Asn Leu Ser Ala Asn Ser Asn Ala Gln Val Leu 485 490 495 agt gga act
gaa ttt tca gcc att cct cat gtc aaa tat ttg gat ttg 1584 Ser Gly
Thr Glu Phe Ser Ala Ile Pro His Val Lys Tyr Leu Asp Leu 500 505 510
aca aac aat aga cta gac ttt gat aat gct agt gct ctt act gaa ttg
1632 Thr Asn Asn Arg Leu Asp Phe Asp Asn Ala Ser Ala Leu Thr Glu
Leu 515 520 525 tcc gac ttg gaa gtt cta gat ctc agc tat aat tca cac
tat ttc aga 1680 Ser Asp Leu Glu Val Leu Asp Leu Ser Tyr Asn Ser
His Tyr Phe Arg 530 535 540 ata gca ggc gta aca cat cat cta gaa ttt
att caa aat ttc aca aat 1728 Ile Ala Gly Val Thr His His Leu Glu
Phe Ile Gln Asn Phe Thr Asn 545 550 555 560 cta aaa gtt tta aac ttg
agc cac aac aac att tat act tta aca gat 1776 Leu Lys Val Leu Asn
Leu Ser His Asn Asn Ile Tyr Thr Leu Thr Asp 565 570 575 aag tat aac
ctg gaa agc aag tcc ctg gta gaa tta gtt ttc agt ggc 1824 Lys Tyr
Asn Leu Glu Ser Lys Ser Leu Val Glu Leu Val Phe Ser Gly 580 585 590
aat cgc ctt gac att ttg tgg aat gat gat gac aac agg tat atc tcc
1872 Asn Arg Leu Asp Ile Leu Trp Asn Asp Asp Asp Asn Arg Tyr Ile
Ser 595 600 605 att ttc aaa ggt ctc aag aat ctg aca cgt ctg gat tta
tcc ctt aat 1920 Ile Phe Lys Gly Leu Lys Asn Leu Thr Arg Leu Asp
Leu Ser Leu Asn 610 615 620 agg ctc aag cac atc cca aat gaa gca ttc
ctt aat ttg cca gcg agt 1968 Arg Leu Lys His Ile Pro Asn Glu Ala
Phe Leu Asn Leu Pro Ala Ser 625 630 635 640 ctc act gaa cta cat ata
aat gat aat atg tta aag ttt ttt aac tgg 2016 Leu Thr Glu Leu His
Ile Asn Asp Asn Met Leu Lys Phe Phe Asn Trp 645 650 655 aca tta ctc
cag cag ttt cct cgt ctc gag ttg ctt gac tta cgt gga 2064 Thr Leu
Leu Gln Gln Phe Pro Arg Leu Glu Leu Leu Asp Leu Arg Gly 660 665 670
aac aaa cta ctc ttt tta act gat agc cta tct gac ttt aca tct tcc
2112 Asn Lys Leu Leu Phe Leu Thr Asp Ser Leu Ser Asp Phe Thr Ser
Ser 675 680 685 ctt cgg aca ctg ctg ctg agt cat aac agg att tcc cac
cta ccc tct 2160 Leu Arg Thr Leu Leu Leu Ser His Asn Arg Ile Ser
His Leu Pro Ser 690 695 700 ggc ttt ctt tct gaa gtc agt agt ctg aag
cac ctc gat tta agt tcc 2208 Gly Phe Leu Ser Glu Val Ser Ser Leu
Lys His Leu Asp Leu Ser Ser 705 710 715 720 aat ctg cta aaa aca atm
aac aaa tcc gca ctt gaa act aag acc acc 2256 Asn Leu Leu Lys Thr
Xaa Asn Lys Ser Ala Leu Glu Thr Lys Thr Thr 725 730 735 acc aaa tta
tct atg ttg gaa cta cac gga aac ccc ttt gaa tgc acc 2304 Thr Lys
Leu Ser Met Leu Glu Leu His Gly Asn Pro Phe Glu Cys Thr 740 745 750
tgt gac att gga gat ttc cga aga tgg atg gat gaa cat ctg aat gtc
2352 Cys Asp Ile Gly Asp Phe Arg Arg Trp Met Asp Glu His Leu Asn
Val 755 760 765 aaa att ccc aga ctg gta gat gtc att tgt gcc agt cct
ggg gat caa 2400 Lys Ile Pro Arg Leu Val Asp Val Ile Cys Ala Ser
Pro Gly Asp Gln 770 775 780 aga ggg aag agt att gtg agt ctg gag cta
aca act tgt gtt tca gat 2448 Arg Gly Lys Ser Ile Val Ser Leu Glu
Leu Thr Thr Cys Val Ser Asp 785 790 795 800 gtc act gca gtg ata tta
ttt ttc ttc acg ttc ttt atc acc acc atg 2496 Val Thr Ala Val Ile
Leu Phe Phe Phe Thr Phe Phe Ile Thr Thr Met 805 810 815 gtt atg ttg
gct gcc ctg gct cac cat ttg ttt tac tgg gat gtt tgg 2544 Val Met
Leu Ala Ala Leu Ala His His Leu Phe Tyr Trp Asp Val Trp 820 825 830
ttt ata tat aat gtg tgt tta gct aag tta aaa ggc tac agg tct ctt
2592 Phe Ile Tyr Asn Val Cys Leu Ala Lys Leu Lys Gly Tyr Arg Ser
Leu 835 840 845 tcc aca tcc caa act ttc tat gat gct tac att tct tat
gac acc aaa 2640 Ser Thr Ser Gln Thr Phe Tyr Asp Ala Tyr Ile Ser
Tyr Asp Thr Lys 850 855 860 gat gcc tct gtt act gac tgg gtg ata aat
gag ctg cgc tac cac ctt 2688 Asp Ala Ser Val Thr Asp Trp Val Ile
Asn Glu Leu Arg Tyr His Leu 865 870 875 880 gaa gag agc cga gac aaa
aac gtt ctc ctt tgt cta gag gag agg gat 2736 Glu Glu Ser Arg Asp
Lys Asn Val Leu Leu Cys Leu Glu Glu Arg Asp 885 890 895
tgg gac ccg gga ttg gcc atc atc gac aac ctc atg cag agc atc aac
2784 Trp Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln Ser Ile
Asn 900 905 910 caa agc aag aaa aca gta ttt gtt tta acc aaa aaa tat
gca aaa agc 2832 Gln Ser Lys Lys Thr Val Phe Val Leu Thr Lys Lys
Tyr Ala Lys Ser 915 920 925 tgg aac ttt aaa aca gct ttt tac ttg gcc
ttg cag agg cta atg ggt 2880 Trp Asn Phe Lys Thr Ala Phe Tyr Leu
Ala Leu Gln Arg Leu Met Gly 930 935 940 gag aac atg gat gtg att ata
ttt atc ctg ctg gag cca gtg tta cag 2928 Glu Asn Met Asp Val Ile
Ile Phe Ile Leu Leu Glu Pro Val Leu Gln 945 950 955 960 cat tct ccg
tat ttg agg cta cgg cag cgg atc tgt aag agc tcc atc 2976 His Ser
Pro Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys Ser Ser Ile 965 970 975
ctc cag tgg cct gac aac ccg aag gca gaa ggc ttg ttt tgg caa act
3024 Leu Gln Trp Pro Asp Asn Pro Lys Ala Glu Gly Leu Phe Trp Gln
Thr 980 985 990 ctg aga aat gtg gtc ttg act gaa aat gat tca cgg tat
aac aat atg 3072 Leu Arg Asn Val Val Leu Thr Glu Asn Asp Ser Arg
Tyr Asn Asn Met 995 1000 1005 tat gtc gat tcc att aag caa tac taa
3099 Tyr Val Asp Ser Ile Lys Gln Tyr 1010 1015 <210> SEQ ID
NO 37 <211> LENGTH: 1032 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (725)..(725) <223> OTHER
INFORMATION: Ile <400> SEQUENCE: 37 Met Leu Thr Cys Ile Phe
Leu Leu Ile Ser Gly Ser Cys Glu Leu Cys -15 -10 -5 -1 1 Ala Glu Glu
Asn Phe Ser Arg Ser Tyr Pro Cys Asp Glu Lys Lys Gln 5 10 15 Asn Asp
Ser Val Ile Ala Glu Cys Ser Asn Arg Arg Leu Gln Glu Val 20 25 30
Pro Gln Thr Val Gly Lys Tyr Val Thr Glu Leu Asp Leu Ser Asp Asn 35
40 45 Phe Ile Thr His Ile Thr Asn Glu Ser Phe Gln Gly Leu Gln Asn
Leu 50 55 60 Thr Lys Ile Asn Leu Asn His Asn Pro Asn Val Gln His
Gln Asn Gly 65 70 75 80 Asn Pro Gly Ile Gln Ser Asn Gly Leu Asn Ile
Thr Asp Gly Ala Phe 85 90 95 Leu Asn Leu Lys Asn Leu Arg Glu Leu
Leu Leu Glu Asp Asn Gln Leu 100 105 110 Pro Gln Ile Pro Ser Gly Leu
Pro Glu Ser Leu Thr Glu Leu Ser Leu 115 120 125 Ile Gln Asn Asn Ile
Tyr Asn Ile Thr Lys Glu Gly Ile Ser Arg Leu 130 135 140 Ile Asn Leu
Lys Asn Leu Tyr Leu Ala Trp Asn Cys Tyr Phe Asn Lys 145 150 155 160
Val Cys Glu Lys Thr Asn Ile Glu Asp Gly Val Phe Glu Thr Leu Thr 165
170 175 Asn Leu Glu Leu Leu Ser Leu Ser Phe Asn Ser Leu Ser His Val
Pro 180 185 190 Pro Lys Leu Pro Ser Ser Leu Arg Lys Leu Phe Leu Ser
Asn Thr Gln 195 200 205 Ile Lys Tyr Ile Ser Glu Glu Asp Phe Lys Gly
Leu Ile Asn Leu Thr 210 215 220 Leu Leu Asp Leu Ser Gly Asn Cys Pro
Arg Cys Phe Asn Ala Pro Phe 225 230 235 240 Pro Cys Val Pro Cys Asp
Gly Gly Ala Ser Ile Asn Ile Asp Arg Phe 245 250 255 Ala Phe Gln Asn
Leu Thr Gln Leu Arg Tyr Leu Asn Leu Ser Ser Thr 260 265 270 Ser Leu
Arg Lys Ile Asn Ala Ala Trp Phe Lys Asn Met Pro His Leu 275 280 285
Lys Val Leu Asp Leu Glu Phe Asn Tyr Leu Val Gly Glu Ile Ala Ser 290
295 300 Gly Ala Phe Leu Thr Met Leu Pro Arg Leu Glu Ile Leu Asp Leu
Ser 305 310 315 320 Phe Asn Tyr Ile Lys Gly Ser Tyr Pro Gln His Ile
Asn Ile Ser Arg 325 330 335 Asn Phe Ser Lys Leu Leu Ser Leu Arg Ala
Leu His Leu Arg Gly Tyr 340 345 350 Val Phe Gln Glu Leu Arg Glu Asp
Asp Phe Gln Pro Leu Met Gln Leu 355 360 365 Pro Asn Leu Ser Thr Ile
Asn Leu Gly Ile Asn Phe Ile Lys Gln Ile 370 375 380 Asp Phe Lys Leu
Phe Gln Asn Phe Ser Asn Leu Glu Ile Ile Tyr Leu 385 390 395 400 Ser
Glu Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr 405 410
415 Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr
420 425 430 Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr
Arg Pro 435 440 445 Leu Ile Lys Pro Gln Cys Ala Ala Tyr Gly Lys Ala
Leu Asp Leu Ser 450 455 460 Leu Asn Ser Ile Phe Phe Ile Gly Pro Asn
Gln Phe Glu Asn Leu Pro 465 470 475 480 Asp Ile Ala Cys Leu Asn Leu
Ser Ala Asn Ser Asn Ala Gln Val Leu 485 490 495 Ser Gly Thr Glu Phe
Ser Ala Ile Pro His Val Lys Tyr Leu Asp Leu 500 505 510 Thr Asn Asn
Arg Leu Asp Phe Asp Asn Ala Ser Ala Leu Thr Glu Leu 515 520 525 Ser
Asp Leu Glu Val Leu Asp Leu Ser Tyr Asn Ser His Tyr Phe Arg 530 535
540 Ile Ala Gly Val Thr His His Leu Glu Phe Ile Gln Asn Phe Thr Asn
545 550 555 560 Leu Lys Val Leu Asn Leu Ser His Asn Asn Ile Tyr Thr
Leu Thr Asp 565 570 575 Lys Tyr Asn Leu Glu Ser Lys Ser Leu Val Glu
Leu Val Phe Ser Gly 580 585 590 Asn Arg Leu Asp Ile Leu Trp Asn Asp
Asp Asp Asn Arg Tyr Ile Ser 595 600 605 Ile Phe Lys Gly Leu Lys Asn
Leu Thr Arg Leu Asp Leu Ser Leu Asn 610 615 620 Arg Leu Lys His Ile
Pro Asn Glu Ala Phe Leu Asn Leu Pro Ala Ser 625 630 635 640 Leu Thr
Glu Leu His Ile Asn Asp Asn Met Leu Lys Phe Phe Asn Trp 645 650 655
Thr Leu Leu Gln Gln Phe Pro Arg Leu Glu Leu Leu Asp Leu Arg Gly 660
665 670 Asn Lys Leu Leu Phe Leu Thr Asp Ser Leu Ser Asp Phe Thr Ser
Ser 675 680 685 Leu Arg Thr Leu Leu Leu Ser His Asn Arg Ile Ser His
Leu Pro Ser 690 695 700 Gly Phe Leu Ser Glu Val Ser Ser Leu Lys His
Leu Asp Leu Ser Ser 705 710 715 720 Asn Leu Leu Lys Thr Xaa Asn Lys
Ser Ala Leu Glu Thr Lys Thr Thr 725 730 735 Thr Lys Leu Ser Met Leu
Glu Leu His Gly Asn Pro Phe Glu Cys Thr 740 745 750 Cys Asp Ile Gly
Asp Phe Arg Arg Trp Met Asp Glu His Leu Asn Val 755 760 765 Lys Ile
Pro Arg Leu Val Asp Val Ile Cys Ala Ser Pro Gly Asp Gln 770 775 780
Arg Gly Lys Ser Ile Val Ser Leu Glu Leu Thr Thr Cys Val Ser Asp 785
790 795 800 Val Thr Ala Val Ile Leu Phe Phe Phe Thr Phe Phe Ile Thr
Thr Met 805 810 815 Val Met Leu Ala Ala Leu Ala His His Leu Phe Tyr
Trp Asp Val Trp 820 825 830 Phe Ile Tyr Asn Val Cys Leu Ala Lys Leu
Lys Gly Tyr Arg Ser Leu 835 840 845 Ser Thr Ser Gln Thr Phe Tyr Asp
Ala Tyr Ile Ser Tyr Asp Thr Lys 850 855 860 Asp Ala Ser Val Thr Asp
Trp Val Ile Asn Glu Leu Arg Tyr His Leu 865 870 875 880 Glu Glu Ser
Arg Asp Lys Asn Val Leu Leu Cys Leu Glu Glu Arg Asp 885 890 895 Trp
Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln Ser Ile Asn 900 905
910 Gln Ser Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr Ala Lys Ser
915 920 925 Trp Asn Phe Lys Thr Ala Phe Tyr Leu Ala Leu Gln Arg Leu
Met Gly 930 935 940 Glu Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu
Pro Val Leu Gln 945 950 955 960 His Ser Pro Tyr Leu Arg Leu Arg Gln
Arg Ile Cys Lys Ser Ser Ile 965 970 975 Leu Gln Trp Pro Asp Asn Pro
Lys Ala Glu Gly Leu Phe Trp Gln Thr 980 985 990 Leu Arg Asn Val Val
Leu Thr Glu Asn Asp Ser Arg Tyr Asn Asn Met 995 1000 1005 Tyr Val
Asp Ser Ile Lys Gln Tyr 1010 1015 <210> SEQ ID NO 38
<211> LENGTH: 3046 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (111)..(2543) <220> FEATURE:
<221> NAME/KEY: mat_peptide <222> LOCATION:
(168)..(2543)
<400> SEQUENCE: 38 gaatcatcca cgcacctgca gctctgctga
gagagtgcaa gccgtggggg ttttgagctc 60 atcttcatca ttcatatgag
gaaataagtg gtaaaatcct tggaaataca atg aga 116 Met Arg ctc atc aga
aac att tac ata ttt tgt agt att gtt atg aca gca gag 164 Leu Ile Arg
Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr Ala Glu -15 -10 -5 -1 1
ggt gat gct cca gag ctg cca gaa gaa agg gaa ctg atg acc aac tgc 212
Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr Asn Cys 5
10 15 tcc aac atg tct cta aga aag gtt ccc gca gac ttg acc cca gcc
aca 260 Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro Ala
Thr 20 25 30 acg aca ctg gat tta tcc tat aac ctc ctt ttt caa ctc
cag agt tca 308 Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu
Gln Ser Ser 35 40 45 gat ttt cat tct gtc tcc aaa ctg aga gtt ttg
att cta tgc cat aac 356 Asp Phe His Ser Val Ser Lys Leu Arg Val Leu
Ile Leu Cys His Asn 50 55 60 aga att caa cag ctg gat ctc aaa acc
ttt gaa ttc aac aag gag tta 404 Arg Ile Gln Gln Leu Asp Leu Lys Thr
Phe Glu Phe Asn Lys Glu Leu 65 70 75 80 aga tat tta gat ttg tct aat
aac aga ctg aag agt gta act tgg tat 452 Arg Tyr Leu Asp Leu Ser Asn
Asn Arg Leu Lys Ser Val Thr Trp Tyr 85 90 95 tta ctg gca ggt ctc
agg tat tta gat ctt tct ttt aat gac ttt gac 500 Leu Leu Ala Gly Leu
Arg Tyr Leu Asp Leu Ser Phe Asn Asp Phe Asp 100 105 110 acc atg cct
atc tgt gag gaa gct ggc aac atg tca cac ctg gaa atc 548 Thr Met Pro
Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu Glu Ile 115 120 125 cta
ggt ttg agt ggg gca aaa ata caa aaa tca gat ttc cag aaa att 596 Leu
Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln Lys Ile 130 135
140 gct cat ctg cat cta aat act gtc ttc tta gga ttc aga act ctt cct
644 Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr Leu Pro
145 150 155 160 cat tat gaa gaa ggt agc ctg ccc atc tta aac aca aca
aaa ctg cac 692 His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr
Lys Leu His 165 170 175 att gtt tta cca atg gac aca aat ttc tgg gtt
ctt ttg cgt gat gga 740 Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val
Leu Leu Arg Asp Gly 180 185 190 atc aag act tca aaa ata tta gaa atg
aca aat ata gat ggc aaa agc 788 Ile Lys Thr Ser Lys Ile Leu Glu Met
Thr Asn Ile Asp Gly Lys Ser 195 200 205 caa ttt gta agt tat gaa atg
caa cga aat ctt agt tta gaa aat gct 836 Gln Phe Val Ser Tyr Glu Met
Gln Arg Asn Leu Ser Leu Glu Asn Ala 210 215 220 aag aca tcg gtt cta
ttg ctt aat aaa gtt gat tta ctc tgg gac gac 884 Lys Thr Ser Val Leu
Leu Leu Asn Lys Val Asp Leu Leu Trp Asp Asp 225 230 235 240 ctt ttc
ctt atc tta caa ttt gtt tgg cat aca tca gtg gaa cac ttt 932 Leu Phe
Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu His Phe 245 250 255
cag atc cga aat gtg act ttt ggt ggt aag gct tat ctt gac cac aat 980
Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp His Asn 260
265 270 tca ttt gac tac tca aat act gta atg aga act ata aaa ttg gag
cat 1028 Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu
Glu His 275 280 285 gta cat ttc aga gtg ttt tac att caa cag gat aaa
atc tat ttg ctt 1076 Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp
Lys Ile Tyr Leu Leu 290 295 300 ttg acc aaa atg gac ata gaa aac ctg
aca ata tca aat gca caa atg 1124 Leu Thr Lys Met Asp Ile Glu Asn
Leu Thr Ile Ser Asn Ala Gln Met 305 310 315 320 cca cac atg ctt ttc
ccg aat tat cct acg aaa ttc caa tat tta aat 1172 Pro His Met Leu
Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr Leu Asn 325 330 335 ttt gcc
aat aat atc tta aca gac gag ttg ttt aaa aga act atc caa 1220 Phe
Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr Ile Gln 340 345
350 ctg cct cac ttg aaa act ctc att ttg aat ggc aat aaa ctg gag aca
1268 Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu Glu
Thr 355 360 365 ctt tct tta gta agt tgc ttt gct aac aac aca ccc ttg
gaa cac ttg 1316 Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro
Leu Glu His Leu 370 375 380 gat ctg agt caa aat cta tta caa cat aaa
aat gat gaa aat tgc tca 1364 Asp Leu Ser Gln Asn Leu Leu Gln His
Lys Asn Asp Glu Asn Cys Ser 385 390 395 400 tgg cca gaa act gtg gtc
aat atg aat ctg tca tac aat aaa ttg tct 1412 Trp Pro Glu Thr Val
Val Asn Met Asn Leu Ser Tyr Asn Lys Leu Ser 405 410 415 gat tct gtc
ttc agg tgc ttg ccc aaa agt att caa ata ctt gac cta 1460 Asp Ser
Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu Asp Leu 420 425 430
aat aat aac caa atc caa act gta cct aaa gag act att cat ctg atg
1508 Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His Leu
Met 435 440 445 gcc tta cga gaa cta aat att gca ttt aat ttt cta act
gat ctc cct 1556 Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu
Thr Asp Leu Pro 450 455 460 gga tgc agt cat ttc agt aga ctt tca gtt
ctg aac att gaa atg aac 1604 Gly Cys Ser His Phe Ser Arg Leu Ser
Val Leu Asn Ile Glu Met Asn 465 470 475 480 ttc att ctc agc cca tct
ctg gat ttt gtt cag agc tgc cag gaa gtt 1652 Phe Ile Leu Ser Pro
Ser Leu Asp Phe Val Gln Ser Cys Gln Glu Val 485 490 495 aaa act cta
aat gcg gga aga aat cca ttc cgg tgt acc tgt gaa tta 1700 Lys Thr
Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys Glu Leu 500 505 510
aaa aat ttc att cag ctt gaa aca tat tca gag gtc atg atg gtt gga
1748 Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met Val
Gly 515 520 525 tgg tca gat tca tac acc tgt gaa tac cct tta aac cta
agg gga act 1796 Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn
Leu Arg Gly Thr 530 535 540 agg tta aaa gac gtt cat ctc cac gaa tta
tct tgc aac aca gct ctg 1844 Arg Leu Lys Asp Val His Leu His Glu
Leu Ser Cys Asn Thr Ala Leu 545 550 555 560 ttg att gtc acc att gtg
gtt att atg cta gtt ctg ggg ttg gct gtg 1892 Leu Ile Val Thr Ile
Val Val Ile Met Leu Val Leu Gly Leu Ala Val 565 570 575 gcc ttc tgc
tgt ctc cac ttt gat ctg ccc tgg tat ctc agg atg cta 1940 Ala Phe
Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg Met Leu 580 585 590
ggt caa tgc aca caa aca tgg cac agg gtt agg aaa aca acc caa gaa
1988 Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr Gln
Glu 595 600 605 caa ctc aag aga aat gtc cga ttc cac gca ttt att tca
tac agt gaa 2036 Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile
Ser Tyr Ser Glu 610 615 620 cat gat tct ctg tgg gtg aag aat gaa ttg
atc ccc aat cta gag aag 2084 His Asp Ser Leu Trp Val Lys Asn Glu
Leu Ile Pro Asn Leu Glu Lys 625 630 635 640 gaa gat ggt tct atc ttg
att tgc ctt tat gaa agc tac ttt gac cct 2132 Glu Asp Gly Ser Ile
Leu Ile Cys Leu Tyr Glu Ser Tyr Phe Asp Pro 645 650 655 ggc aaa agc
att agt gaa aat att gta agc ttc att gag aaa agc tat 2180 Gly Lys
Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys Ser Tyr 660 665 670
aag tcc atc ttt gtt ttg tct ccc aac ttt gtc cag aat gag tgg tgc
2228 Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu Trp
Cys 675 680 685 cat tat gaa ttc tac ttt gcc cac cac aat ctc ttc cat
gaa aat tct 2276 His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe
His Glu Asn Ser 690 695 700 gat cat ata att ctt atc tta ctg gaa ccc
att cca ttc tat tgc att 2324 Asp His Ile Ile Leu Ile Leu Leu Glu
Pro Ile Pro Phe Tyr Cys Ile 705 710 715 720 ccc acc agg tat cat aaa
ctg aaa gct ctc ctg gaa aaa aaa gca tac 2372 Pro Thr Arg Tyr His
Lys Leu Lys Ala Leu Leu Glu Lys Lys Ala Tyr 725 730 735 ttg gaa tgg
ccc aag gat agg cgt aaa tgt ggg ctt ttc tgg gca aac 2420 Leu Glu
Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp Ala Asn 740 745 750
ctt cga gct gct att aat gtt aat gta tta gcc acc aga gaa atg tat
2468 Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu Met
Tyr 755 760 765 gaa ctg cag aca ttc aca gag tta aat gaa gag tct cga
ggt tct aca 2516 Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser
Arg Gly Ser Thr 770 775 780 atc tct ctg atg aga aca gat tgt cta
taaaatccca cagtccttgg 2563 Ile Ser Leu Met Arg Thr Asp Cys Leu 785
790 gaagttgggg accacataca ctgttgggat gtacattgat acaaccttta
tgatggcaat 2623 ttgacaatat ttattaaaat aaaaaatggt tattcccttc
atatcagttt ctagaaggat 2683 ttctaagaat gtatcctata gaaacacctt
cacaagttta taagggctta tggaaaaagg 2743 tgttcatccc aggattgttt
ataatcatga aaaatgtggc caggtgcagt ggctcactct 2803 tgtaatccca
gcactatggg aggccaaggt gggtgaccca cgaggtcaag agatggagac 2863
catcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctgggcgt
2923 gatggtgcac gcctgtagtc ccagctactt gggaggctga ggcaggagaa
tcgcttgaac 2983 ccgggaggtg gcagttgcag tgagctgaga tcgagccact
gcactccagc ctggtgacag 3043 agc 3046 <210> SEQ ID NO 39
<211> LENGTH: 811 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 39 Met Arg Leu Ile Arg Asn Ile
Tyr Ile Phe Cys Ser Ile Val Met Thr -15 -10 -5 -1 1 Ala Glu Gly Asp
Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 5 10 15 Asn Cys Ser
Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 20 25 30 Ala
Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 35 40
45 Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu
Cys
50 55 60 His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe
Asn Lys 65 70 75 80 Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu
Lys Ser Val Thr 85 90 95 Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu
Asp Leu Ser Phe Asn Asp 100 105 110 Phe Asp Thr Met Pro Ile Cys Glu
Glu Ala Gly Asn Met Ser His Leu 115 120 125 Glu Ile Leu Gly Leu Ser
Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 130 135 140 Lys Ile Ala His
Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 145 150 155 160 Leu
Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 165 170
175 Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg
180 185 190 Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile
Asp Gly 195 200 205 Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn
Leu Ser Leu Glu 210 215 220 Asn Ala Lys Thr Ser Val Leu Leu Leu Asn
Lys Val Asp Leu Leu Trp 225 230 235 240 Asp Asp Leu Phe Leu Ile Leu
Gln Phe Val Trp His Thr Ser Val Glu 245 250 255 His Phe Gln Ile Arg
Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 260 265 270 His Asn Ser
Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 275 280 285 Glu
His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 290 295
300 Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala
305 310 315 320 Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys
Phe Gln Tyr 325 330 335 Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu
Leu Phe Lys Arg Thr 340 345 350 Ile Gln Leu Pro His Leu Lys Thr Leu
Ile Leu Asn Gly Asn Lys Leu 355 360 365 Glu Thr Leu Ser Leu Val Ser
Cys Phe Ala Asn Asn Thr Pro Leu Glu 370 375 380 His Leu Asp Leu Ser
Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 385 390 395 400 Cys Ser
Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 405 410 415
Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 420
425 430 Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile
His 435 440 445 Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe
Leu Thr Asp 450 455 460 Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser
Val Leu Asn Ile Glu 465 470 475 480 Met Asn Phe Ile Leu Ser Pro Ser
Leu Asp Phe Val Gln Ser Cys Gln 485 490 495 Glu Val Lys Thr Leu Asn
Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 500 505 510 Glu Leu Lys Asn
Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 515 520 525 Val Gly
Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 530 535 540
Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 545
550 555 560 Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu
Gly Leu 565 570 575 Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro
Trp Tyr Leu Arg 580 585 590 Met Leu Gly Gln Cys Thr Gln Thr Trp His
Arg Val Arg Lys Thr Thr 595 600 605 Gln Glu Gln Leu Lys Arg Asn Val
Arg Phe His Ala Phe Ile Ser Tyr 610 615 620 Ser Glu His Asp Ser Leu
Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 625 630 635 640 Glu Lys Glu
Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 645 650 655 Asp
Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 660 665
670 Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu
675 680 685 Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe
His Glu 690 695 700 Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro
Ile Pro Phe Tyr 705 710 715 720 Cys Ile Pro Thr Arg Tyr His Lys Leu
Lys Ala Leu Leu Glu Lys Lys 725 730 735 Ala Tyr Leu Glu Trp Pro Lys
Asp Arg Arg Lys Cys Gly Leu Phe Trp 740 745 750 Ala Asn Leu Arg Ala
Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 755 760 765 Met Tyr Glu
Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 770 775 780 Ser
Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 785 790 795 <210> SEQ
ID NO 40 <211> LENGTH: 2760 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (68)..(2455) <220> FEATURE:
<221> NAME/KEY: mat_peptide <222> LOCATION:
(161)..(2455) <220> FEATURE: <221> NAME/KEY:
modified_base <222> LOCATION: (2529)..(2529) <223>
OTHER INFORMATION: a, c, t, g, unknown or other <400>
SEQUENCE: 40 aagaatttgg actcatatca agatgctctg aagaagaaca accctttagg
atagccactg 60 caacatc atg acc aaa gac aaa gaa cct att gtt aaa agc
ttc cat ttt 109 Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His
Phe -30 -25 -20 gtt tgc ctt atg atc ata ata gtt gga acc aga atc cag
ttc tcc gac 157 Val Cys Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln
Phe Ser Asp -15 -10 -5 gga aat gaa ttt gca gta gac aag tca aaa aga
ggt ctt att cat gtt 205 Gly Asn Glu Phe Ala Val Asp Lys Ser Lys Arg
Gly Leu Ile His Val -1 1 5 10 15 cca aaa gac cta ccg ctg aaa acc
aaa gtc tta gat atg tct cag aac 253 Pro Lys Asp Leu Pro Leu Lys Thr
Lys Val Leu Asp Met Ser Gln Asn 20 25 30 tac atc gct gag ctt cag
gtc tct gac atg agc ttt cta tca gag ttg 301 Tyr Ile Ala Glu Leu Gln
Val Ser Asp Met Ser Phe Leu Ser Glu Leu 35 40 45 aca gtt ttg aga
ctt tcc cat aac aga atc cag cta ctt gat tta agt 349 Thr Val Leu Arg
Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser 50 55 60 gtt ttc
aag ttc aac cag gat tta gaa tat ttg gat tta tct cat aat 397 Val Phe
Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn 65 70 75
cag ttg caa aag ata tcc tgc cat cct att gtg agt ttc agg cat tta 445
Gln Leu Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu 80
85 90 95 gat ctc tca ttc aat gat ttc aag gcc ctg ccc atc tgt aag
gaa ttt 493 Asp Leu Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys
Glu Phe 100 105 110 ggc aac tta tca caa ctg aat ttc ttg gga ttg agt
gct atg aag ctg 541 Gly Asn Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser
Ala Met Lys Leu 115 120 125 caa aaa tta gat ttg ctg cca att gct cac
ttg cat cta agt tat atc 589 Gln Lys Leu Asp Leu Leu Pro Ile Ala His
Leu His Leu Ser Tyr Ile 130 135 140 ctt ctg gat tta aga aat tat tat
ata aaa gaa aat gag aca gaa agt 637 Leu Leu Asp Leu Arg Asn Tyr Tyr
Ile Lys Glu Asn Glu Thr Glu Ser 145 150 155 160 cta caa att ctg aat
gca aaa acc ctt cac ctt gtt ttt cac cca act 685 Leu Gln Ile Leu Asn
Ala Lys Thr Leu His Leu Val Phe His Pro Thr 165 170 175 agt tta ttc
gct atc caa gtg aac ata tca gtt aat act tta ggg tgc 733 Ser Leu Phe
Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys 180 185 190 tta
caa ctg act aat att aaa ttg aat gat gac aac tgt caa gtt ttc 781 Leu
Gln Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe 195 200
205 att aaa ttt tta tca gaa ctc acc aga ggt cca acc tta ctg aat ttt
829 Ile Lys Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe
210 215 220 acc ctc aac cac ata gaa acg act tgg aaa tgc ctg gtc aga
gtc ttt 877 Thr Leu Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg
Val Phe 225 230 235 240 caa ttt ctt tgg ccc aaa cct gtg gaa tat ctc
aat att tac aat tta 925 Gln Phe Leu Trp Pro Lys Pro Val Glu Tyr Leu
Asn Ile Tyr Asn Leu 245 250 255 aca ata att gaa agc att cgt gaa gaa
gat ttt act tat tct aaa acg 973 Thr Ile Ile Glu Ser Ile Arg Glu Glu
Asp Phe Thr Tyr Ser Lys Thr 260 265 270 aca ttg aaa gca ttg aca ata
gaa cat atc acg aac caa gtt ttt ctg 1021 Thr Leu Lys Ala Leu Thr
Ile Glu His Ile Thr Asn Gln Val Phe Leu 275 280 285 ttt tca cag aca
gct ttg tac acc gtg ttt tct gag atg aac att atg 1069 Phe Ser Gln
Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met 290 295 300 atg
tta acc att tca gat aca cct ttt ata cac atg ctg tgt cct cat 1117
Met Leu Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His 305
310 315 320 gca cca agc aca ttc aag ttt ttg aac ttt acc cag aac gtt
ttc aca 1165 Ala Pro Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn
Val Phe Thr 325 330 335
gat agt att ttt gaa aaa tgt tcc acg tta gtt aaa ttg gag aca ctt
1213 Asp Ser Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr
Leu 340 345 350 atc tta caa aag aat gga tta aaa gac ctt ttc aaa gta
ggt ctc atg 1261 Ile Leu Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys
Val Gly Leu Met 355 360 365 acg aag gat atg cct tct ttg gaa ata ctg
gat gtt agc tgg aat tct 1309 Thr Lys Asp Met Pro Ser Leu Glu Ile
Leu Asp Val Ser Trp Asn Ser 370 375 380 ttg gaa tct ggt aga cat aaa
gaa aac tgc act tgg gtt gag agt ata 1357 Leu Glu Ser Gly Arg His
Lys Glu Asn Cys Thr Trp Val Glu Ser Ile 385 390 395 400 gtg gtg tta
aat ttg tct tca aat atg ctt act gac tct gtt ttc aga 1405 Val Val
Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg 405 410 415
tgt tta cct ccc agg atc aag gta ctt gat ctt cac agc aat aaa ata
1453 Cys Leu Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys
Ile 420 425 430 aag agc gtt cct aaa caa gtc gta aaa ctg gaa gct ttg
caa gaa ctc 1501 Lys Ser Val Pro Lys Gln Val Val Lys Leu Glu Ala
Leu Gln Glu Leu 435 440 445 aat gtt gct ttc aat tct tta act gac ctt
cct gga tgt ggc agc ttt 1549 Asn Val Ala Phe Asn Ser Leu Thr Asp
Leu Pro Gly Cys Gly Ser Phe 450 455 460 agc agc ctt tct gta ttg atc
att gat cac aat tca gtt tcc cac cca 1597 Ser Ser Leu Ser Val Leu
Ile Ile Asp His Asn Ser Val Ser His Pro 465 470 475 480 tcg gct gat
ttc ttc cag agc tgc cag aag atg agg tca ata aaa gca 1645 Ser Ala
Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala 485 490 495
ggg gac aat cca ttc caa tgt acc tgt gag cta aga gaa ttt gtc aaa
1693 Gly Asp Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val
Lys 500 505 510 aat ata gac caa gta tca agt gaa gtg tta gag ggc tgg
cct gat tct 1741 Asn Ile Asp Gln Val Ser Ser Glu Val Leu Glu Gly
Trp Pro Asp Ser 515 520 525 tat aag tgt gac tac cca gaa agt tat aga
gga agc cca cta aag gac 1789 Tyr Lys Cys Asp Tyr Pro Glu Ser Tyr
Arg Gly Ser Pro Leu Lys Asp 530 535 540 ttt cac atg tct gaa tta tcc
tgc aac ata act ctg ctg atc gtc acc 1837 Phe His Met Ser Glu Leu
Ser Cys Asn Ile Thr Leu Leu Ile Val Thr 545 550 555 560 atc ggt gcc
acc atg ctg gtg ttg gct gtg act gtg acc tcc ctc tgc 1885 Ile Gly
Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys 565 570 575
atc tac ttg gat ctg ccc tgg tat ctc agg atg gtg tgc cag tgg acc
1933 Ile Tyr Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp
Thr 580 585 590 cag act cgg cgc agg gcc agg aac ata ccc tta gaa gaa
ctc caa aga 1981 Gln Thr Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu
Glu Leu Gln Arg 595 600 605 aac ctc cag ttt cat gct ttt att tca tat
agt gaa cat gat tct gcc 2029 Asn Leu Gln Phe His Ala Phe Ile Ser
Tyr Ser Glu His Asp Ser Ala 610 615 620 tgg gtg aaa agt gaa ttg gta
cct tac cta gaa aaa gaa gat ata cag 2077 Trp Val Lys Ser Glu Leu
Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln 625 630 635 640 att tgt ctt
cat gag agg aac ttt gtc cct ggc aag agc att gtg gaa 2125 Ile Cys
Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu 645 650 655
aat atc atc aac tgc att gag aag agt tac aag tcc atc ttt gtt ttg
2173 Asn Ile Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val
Leu 660 665 670 tct ccc aac ttt gtc cag agt gag tgg tgc cat tac gaa
ctc tat ttt 2221 Ser Pro Asn Phe Val Gln Ser Glu Trp Cys His Tyr
Glu Leu Tyr Phe 675 680 685 gcc cat cac aat ctc ttt cat gaa gga tct
aat aac tta atc ctc atc 2269 Ala His His Asn Leu Phe His Glu Gly
Ser Asn Asn Leu Ile Leu Ile 690 695 700 tta ctg gaa ccc att cca cag
aac agc att ccc aac aag tac cac aag 2317 Leu Leu Glu Pro Ile Pro
Gln Asn Ser Ile Pro Asn Lys Tyr His Lys 705 710 715 720 ctg aag gct
ctc atg acg cag cgg act tat ttg cag tgg ccc aag gag 2365 Leu Lys
Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu 725 730 735
aaa agc aaa cgt ggg ctc ttt tgg gct aac att aga gcc gct ttt aat
2413 Lys Ser Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe
Asn 740 745 750 atg aaa tta aca cta gtc act gaa aac aat gat gtg aaa
tct 2455 Met Lys Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser
755 760 765 taaaaaaatt taggaaattc aacttaagaa accattattt acttggatga
tggtgaatag 2515 tacagtcgta agtnactgtc tggaggtgcc tccattatcc
tcatgccttc aggaaagact 2575 taacaaaaac aatgtttcat ctggggaact
gagctaggcg gtgaggttag cctgccagtt 2635 agagacagcc cagtctcttc
tggtttaatc attatgtttc aaattgaaac agtctctttt 2695 gagtaaatgc
tcagtttttc agctcctctc cactctgctt tcccaaatgg attctgttgg 2755 tgaag
2760 <210> SEQ ID NO 41 <211> LENGTH: 796 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
41 Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys
-30 -25 -20 Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp
Gly Asn -15 -10 -5 -1 1 Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu
Ile His Val Pro Lys 5 10 15 Asp Leu Pro Leu Lys Thr Lys Val Leu Asp
Met Ser Gln Asn Tyr Ile 20 25 30 Ala Glu Leu Gln Val Ser Asp Met
Ser Phe Leu Ser Glu Leu Thr Val 35 40 45 Leu Arg Leu Ser His Asn
Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 50 55 60 Lys Phe Asn Gln
Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 65 70 75 80 Gln Lys
Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 85 90 95
Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 100
105 110 Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln
Lys 115 120 125 Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr
Ile Leu Leu 130 135 140 Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu
Thr Glu Ser Leu Gln 145 150 155 160 Ile Leu Asn Ala Lys Thr Leu His
Leu Val Phe His Pro Thr Ser Leu 165 170 175 Phe Ala Ile Gln Val Asn
Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 180 185 190 Leu Thr Asn Ile
Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 195 200 205 Phe Leu
Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 210 215 220
Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 225
230 235 240 Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu
Thr Ile 245 250 255 Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser
Lys Thr Thr Leu 260 265 270 Lys Ala Leu Thr Ile Glu His Ile Thr Asn
Gln Val Phe Leu Phe Ser 275 280 285 Gln Thr Ala Leu Tyr Thr Val Phe
Ser Glu Met Asn Ile Met Met Leu 290 295 300 Thr Ile Ser Asp Thr Pro
Phe Ile His Met Leu Cys Pro His Ala Pro 305 310 315 320 Ser Thr Phe
Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 325 330 335 Ile
Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 340 345
350 Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys
355 360 365 Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser
Leu Glu 370 375 380 Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu
Ser Ile Val Val 385 390 395 400 Leu Asn Leu Ser Ser Asn Met Leu Thr
Asp Ser Val Phe Arg Cys Leu 405 410 415 Pro Pro Arg Ile Lys Val Leu
Asp Leu His Ser Asn Lys Ile Lys Ser 420 425 430 Val Pro Lys Gln Val
Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 435 440 445 Ala Phe Asn
Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 450 455 460 Leu
Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 465 470
475 480 Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly
Asp 485 490 495 Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val
Lys Asn Ile 500 505 510 Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp
Pro Asp Ser Tyr Lys 515 520 525 Cys Asp Tyr Pro Glu Ser Tyr Arg Gly
Ser Pro Leu Lys Asp Phe His 530 535 540 Met Ser Glu Leu Ser Cys Asn
Ile Thr Leu Leu Ile Val Thr Ile Gly 545 550 555 560 Ala Thr Met Leu
Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 565 570 575 Leu Asp
Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 580 585 590
Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 595
600 605 Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp
Val 610 615 620
Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 625
630 635 640 Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu
Asn Ile 645 650 655 Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe
Val Leu Ser Pro 660 665 670 Asn Phe Val Gln Ser Glu Trp Cys His Tyr
Glu Leu Tyr Phe Ala His 675 680 685 His Asn Leu Phe His Glu Gly Ser
Asn Asn Leu Ile Leu Ile Leu Leu 690 695 700 Glu Pro Ile Pro Gln Asn
Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 705 710 715 720 Ala Leu Met
Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 725 730 735 Lys
Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 740 745
750 Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 755 760
<210> SEQ ID NO 42 <211> LENGTH: 3168 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(3165)
<220> FEATURE: <221> NAME/KEY: mat_peptide <222>
LOCATION: (145)..(3165) <400> SEQUENCE: 42 atg ccc atg aag
tgg agt ggg tgg agg tgg agc tgg ggg ccg gcc act 48 Met Pro Met Lys
Trp Ser Gly Trp Arg Trp Ser Trp Gly Pro Ala Thr -45 -40 -35 cac aca
gcc ctc cca ccc cca cag ggt ttc tgc cgc agc gcc ctg cac 96 His Thr
Ala Leu Pro Pro Pro Gln Gly Phe Cys Arg Ser Ala Leu His -30 -25 -20
ccg ctg tct ctc ctg gtg cag gcc atc atg ctg gcc atg acc ctg gcc 144
Pro Leu Ser Leu Leu Val Gln Ala Ile Met Leu Ala Met Thr Leu Ala -15
-10 -5 -1 ctg ggt acc ttg cct gcc ttc cta ccc tgt gag ctc cag ccc
cac ggc 192 Leu Gly Thr Leu Pro Ala Phe Leu Pro Cys Glu Leu Gln Pro
His Gly 1 5 10 15 ctg gtg aac tgc aac tgg ctg ttc ctg aag tct gtg
ccc cac ttc tcc 240 Leu Val Asn Cys Asn Trp Leu Phe Leu Lys Ser Val
Pro His Phe Ser 20 25 30 atg gca gca ccc cgt ggc aat gtc acc agc
ctt tcc ttg tcc tcc aac 288 Met Ala Ala Pro Arg Gly Asn Val Thr Ser
Leu Ser Leu Ser Ser Asn 35 40 45 cgc atc cac cac ctc cat gat tct
gac ttt gcc cac ctg ccc agc ctg 336 Arg Ile His His Leu His Asp Ser
Asp Phe Ala His Leu Pro Ser Leu 50 55 60 cgg cat ctc aac ctc aag
tgg aac tgc ccg ccg gtt ggc ctc agc ccc 384 Arg His Leu Asn Leu Lys
Trp Asn Cys Pro Pro Val Gly Leu Ser Pro 65 70 75 80 atg cac ttc ccc
tgc cac atg acc atc gag ccc agc acc ttc ttg gct 432 Met His Phe Pro
Cys His Met Thr Ile Glu Pro Ser Thr Phe Leu Ala 85 90 95 gtg ccc
acc ctg gaa gag cta aac ctg agc tac aac aac atc atg act 480 Val Pro
Thr Leu Glu Glu Leu Asn Leu Ser Tyr Asn Asn Ile Met Thr 100 105 110
gtg cct gcg ctg ccc aaa tcc ctc ata tcc ctg tcc ctc agc cat acc 528
Val Pro Ala Leu Pro Lys Ser Leu Ile Ser Leu Ser Leu Ser His Thr 115
120 125 aac atc ctg atg cta gac tct gcc agc ctc gcc ggc ctg cat gcc
ctg 576 Asn Ile Leu Met Leu Asp Ser Ala Ser Leu Ala Gly Leu His Ala
Leu 130 135 140 cgc ttc cta ttc atg gac ggc aac tgt tat tac aag aac
ccc tgc agg 624 Arg Phe Leu Phe Met Asp Gly Asn Cys Tyr Tyr Lys Asn
Pro Cys Arg 145 150 155 160 cag gca ctg gag gtg gcc ccg ggt gcc ctc
ctt ggc ctg ggc aac ctc 672 Gln Ala Leu Glu Val Ala Pro Gly Ala Leu
Leu Gly Leu Gly Asn Leu 165 170 175 acc cac ctg tca ctc aag tac aac
aac ctc act gtg gtg ccc cgc aac 720 Thr His Leu Ser Leu Lys Tyr Asn
Asn Leu Thr Val Val Pro Arg Asn 180 185 190 ctg cct tcc agc ctg gag
tat ctg ctg ttg tcc tac aac cgc atc gtc 768 Leu Pro Ser Ser Leu Glu
Tyr Leu Leu Leu Ser Tyr Asn Arg Ile Val 195 200 205 aaa ctg gcg cct
gag gac ctg gcc aat ctg acc gcc ctg cgt gtg ctc 816 Lys Leu Ala Pro
Glu Asp Leu Ala Asn Leu Thr Ala Leu Arg Val Leu 210 215 220 gat gtg
ggc gga aat tgc cgc cgc tgc gac cac gct ccc aac ccc tgc 864 Asp Val
Gly Gly Asn Cys Arg Arg Cys Asp His Ala Pro Asn Pro Cys 225 230 235
240 atg gag tgc cct cgt cac ttc ccc cag cta cat ccc gat acc ttc agc
912 Met Glu Cys Pro Arg His Phe Pro Gln Leu His Pro Asp Thr Phe Ser
245 250 255 cac ctg agc cgt ctt gaa ggc ctg gtg ttg aag gac agt tct
ctc tcc 960 His Leu Ser Arg Leu Glu Gly Leu Val Leu Lys Asp Ser Ser
Leu Ser 260 265 270 tgg ctg aat gcc agt tgg ttc cgt ggg ctg gga aac
ctc cga gtg ctg 1008 Trp Leu Asn Ala Ser Trp Phe Arg Gly Leu Gly
Asn Leu Arg Val Leu 275 280 285 gac ctg agt gag aac ttc ctc tac aaa
tgc atc act aaa acc aag gcc 1056 Asp Leu Ser Glu Asn Phe Leu Tyr
Lys Cys Ile Thr Lys Thr Lys Ala 290 295 300 ttc cag ggc cta aca cag
ctg cgc aag ctt aac ctg tcc ttc aat tac 1104 Phe Gln Gly Leu Thr
Gln Leu Arg Lys Leu Asn Leu Ser Phe Asn Tyr 305 310 315 320 caa aag
agg gtg tcc ttt gcc cac ctg tct ctg gcc cct tcc ttc ggg 1152 Gln
Lys Arg Val Ser Phe Ala His Leu Ser Leu Ala Pro Ser Phe Gly 325 330
335 agc ctg gtc gcc ctg aag gag ctg gac atg cac ggc atc ttc ttc cgc
1200 Ser Leu Val Ala Leu Lys Glu Leu Asp Met His Gly Ile Phe Phe
Arg 340 345 350 tca ctc gat gag acc acg ctc cgg cca ctg gcc cgc ctg
ccc atg ctc 1248 Ser Leu Asp Glu Thr Thr Leu Arg Pro Leu Ala Arg
Leu Pro Met Leu 355 360 365 cag act ctg cgt ctg cag atg aac ttc atc
aac cag gcc cag ctc ggc 1296 Gln Thr Leu Arg Leu Gln Met Asn Phe
Ile Asn Gln Ala Gln Leu Gly 370 375 380 atc ttc agg gcc ttc cct ggc
ctg cgc tac gtg gac ctg tcg gac aac 1344 Ile Phe Arg Ala Phe Pro
Gly Leu Arg Tyr Val Asp Leu Ser Asp Asn 385 390 395 400 cgc atc agc
gga gct tcg gag ctg aca gcc acc atg ggg gag gca gat 1392 Arg Ile
Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp 405 410 415
gga ggg gag aag gtc tgg ctg cag cct ggg gac ctt gct ccg gcc cca
1440 Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala
Pro 420 425 430 gtg gac act ccc agc tct gaa gac ttc agg ccc aac tgc
agc acc ctc 1488 Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn
Cys Ser Thr Leu 435 440 445 aac ttc acc ttg gat ctg tca cgg aac aac
ctg gtg acc gtg cag ccg 1536 Asn Phe Thr Leu Asp Leu Ser Arg Asn
Asn Leu Val Thr Val Gln Pro 450 455 460 gag atg ttt gcc cag ctc tcg
cac ctg cag tgc ctg cgc ctg agc cac 1584 Glu Met Phe Ala Gln Leu
Ser His Leu Gln Cys Leu Arg Leu Ser His 465 470 475 480 aac tgc atc
tcg cag gca gtc aat ggc tcc cag ttc ctg ccg ctg acc 1632 Asn Cys
Ile Ser Gln Ala Val Asn Gly Ser Gln Phe Leu Pro Leu Thr 485 490 495
ggt ctg cag gtg cta gac ctg tcc cac aat aag ctg gac ctc tac cac
1680 Gly Leu Gln Val Leu Asp Leu Ser His Asn Lys Leu Asp Leu Tyr
His 500 505 510 gag cac tca ttc acg gag cta cca cga ctg gag gcc ctg
gac ctc agc 1728 Glu His Ser Phe Thr Glu Leu Pro Arg Leu Glu Ala
Leu Asp Leu Ser 515 520 525 tac aac agc cag ccc ttt ggc atg cag ggc
gtg ggc cac aac ttc agc 1776 Tyr Asn Ser Gln Pro Phe Gly Met Gln
Gly Val Gly His Asn Phe Ser 530 535 540 ttc gtg gct cac ctg cgc acc
ctg cgc cac ctc agc ctg gcc cac aac 1824 Phe Val Ala His Leu Arg
Thr Leu Arg His Leu Ser Leu Ala His Asn 545 550 555 560 aac atc cac
agc caa gtg tcc cag cag ctc tgc agt acg tcg ctg cgg 1872 Asn Ile
His Ser Gln Val Ser Gln Gln Leu Cys Ser Thr Ser Leu Arg 565 570 575
gcc ctg gac ttc agc ggc aat gca ctg ggc cat atg tgg gcc gag gga
1920 Ala Leu Asp Phe Ser Gly Asn Ala Leu Gly His Met Trp Ala Glu
Gly 580 585 590 gac ctc tat ctg cac ttc ttc caa ggc ctg agc ggt ttg
atc tgg ctg 1968 Asp Leu Tyr Leu His Phe Phe Gln Gly Leu Ser Gly
Leu Ile Trp Leu 595 600 605 gac ttg tcc cag aac cgc ctg cac acc ctc
ctg ccc caa acc ctg cgc 2016 Asp Leu Ser Gln Asn Arg Leu His Thr
Leu Leu Pro Gln Thr Leu Arg 610 615 620 aac ctc ccc aag agc cta cag
gtg ctg cgt ctc cgt gac aat tac ctg 2064 Asn Leu Pro Lys Ser Leu
Gln Val Leu Arg Leu Arg Asp Asn Tyr Leu 625 630 635 640 gcc ttc ttt
aag tgg tgg agc ctc cac ttc ctg ccc aaa ctg gaa gtc 2112 Ala Phe
Phe Lys Trp Trp Ser Leu His Phe Leu Pro Lys Leu Glu Val 645 650 655
ctc gac ctg gca gga aac cag ctg aag gcc ctg acc aat ggc agc ctg
2160 Leu Asp Leu Ala Gly Asn Gln Leu Lys Ala Leu Thr Asn Gly Ser
Leu 660 665 670 cct gct ggc acc cgg ctc cgg agg ctg gat gtc agc tgc
aac agc atc 2208 Pro Ala Gly Thr Arg Leu Arg Arg Leu Asp Val Ser
Cys Asn Ser Ile 675 680 685 agc ttc gtg gcc ccc ggc ttc ttt tcc aag
gcc aag gag ctg cga gag 2256 Ser Phe Val Ala Pro Gly Phe Phe Ser
Lys Ala Lys Glu Leu Arg Glu 690 695 700 ctc aac ctt agc gcc aac gcc
ctc aag aca gtg gac cac tcc tgg ttt 2304 Leu Asn Leu Ser Ala Asn
Ala Leu Lys Thr Val Asp His Ser Trp Phe 705 710 715 720 ggg ccc ctg
gcg agt gcc ctg caa ata cta gat gta agc gcc aac cct 2352 Gly Pro
Leu Ala Ser Ala Leu Gln Ile Leu Asp Val Ser Ala Asn Pro 725 730 735
ctg cac tgc gcc tgt ggg gcg gcc ttt atg gac ttc ctg ctg gag gtg
2400 Leu His Cys Ala Cys Gly Ala Ala Phe Met Asp Phe Leu Leu Glu
Val 740 745 750 cag gct gcc gtg ccc ggt ctg ccc agc cgg gtg aag tgt
ggc agt ccg 2448 Gln Ala Ala Val Pro Gly Leu Pro Ser Arg Val Lys
Cys Gly Ser Pro 755 760 765 ggc cag ctc cag ggc ctc agc atc ttt gca
cag gac ctg cgc ctc tgc 2496 Gly Gln Leu Gln Gly Leu Ser Ile Phe
Ala Gln Asp Leu Arg Leu Cys 770 775 780 ctg gat gag gcc ctc tcc tgg
gac tgt ttc gcc ctc tcg ctg ctg gct 2544
Leu Asp Glu Ala Leu Ser Trp Asp Cys Phe Ala Leu Ser Leu Leu Ala 785
790 795 800 gtg gct ctg ggc ctg ggt gtg ccc atg ctg cat cac ctc tgt
ggc tgg 2592 Val Ala Leu Gly Leu Gly Val Pro Met Leu His His Leu
Cys Gly Trp 805 810 815 gac ctc tgg tac tgc ttc cac ctg tgc ctg gcc
tgg ctt ccc tgg cgg 2640 Asp Leu Trp Tyr Cys Phe His Leu Cys Leu
Ala Trp Leu Pro Trp Arg 820 825 830 ggg cgg caa agt ggg cga gat gag
gat gcc ctg ccc tac gat gcc ttc 2688 Gly Arg Gln Ser Gly Arg Asp
Glu Asp Ala Leu Pro Tyr Asp Ala Phe 835 840 845 gtg gtc ttc gac aaa
acg cag agc gca gtg gca gac tgg gtg tac aac 2736 Val Val Phe Asp
Lys Thr Gln Ser Ala Val Ala Asp Trp Val Tyr Asn 850 855 860 gag ctt
cgg ggg cag ctg gag gag tgc cgt ggg cgc tgg gca ctc cgc 2784 Glu
Leu Arg Gly Gln Leu Glu Glu Cys Arg Gly Arg Trp Ala Leu Arg 865 870
875 880 ctg tgc ctg gag gaa cgc gac tgg ctg cct ggc aaa acc ctc ttt
gag 2832 Leu Cys Leu Glu Glu Arg Asp Trp Leu Pro Gly Lys Thr Leu
Phe Glu 885 890 895 aac ctg tgg gcc tcg gtc tat ggc agc cgc aag acg
ctg ttt gtg ctg 2880 Asn Leu Trp Ala Ser Val Tyr Gly Ser Arg Lys
Thr Leu Phe Val Leu 900 905 910 gcc cac acg gac cgg gtc agt ggt ctc
ttg cgc gcc agc ttc ctg ctg 2928 Ala His Thr Asp Arg Val Ser Gly
Leu Leu Arg Ala Ser Phe Leu Leu 915 920 925 gcc cag cag cgc ctg ctg
gag gac cgc aag gac gtc gtg gtg ctg gtg 2976 Ala Gln Gln Arg Leu
Leu Glu Asp Arg Lys Asp Val Val Val Leu Val 930 935 940 atc ctg agc
cct gac ggc cgc cgc tcc cgc tat gtg cgg ctg cgc cag 3024 Ile Leu
Ser Pro Asp Gly Arg Arg Ser Arg Tyr Val Arg Leu Arg Gln 945 950 955
960 cgc ctc tgc cgc cag agt gtc ctc ctc tgg ccc cac cag ccc agt ggt
3072 Arg Leu Cys Arg Gln Ser Val Leu Leu Trp Pro His Gln Pro Ser
Gly 965 970 975 cag cgc agc ttc tgg gcc cag ctg ggc atg gcc ctg acc
agg gac aac 3120 Gln Arg Ser Phe Trp Ala Gln Leu Gly Met Ala Leu
Thr Arg Asp Asn 980 985 990 cac cac ttc tat aac cgg aac ttc tgc cag
gga ccc acg gcc gaa tag 3168 His His Phe Tyr Asn Arg Asn Phe Cys
Gln Gly Pro Thr Ala Glu 995 1000 1005 <210> SEQ ID NO 43
<211> LENGTH: 1055 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 43 Met Pro Met Lys Trp
Ser Gly Trp Arg Trp Ser Trp Gly Pro Ala Thr -45 -40 -35 His Thr Ala
Leu Pro Pro Pro Gln Gly Phe Cys Arg Ser Ala Leu His -30 -25 -20 Pro
Leu Ser Leu Leu Val Gln Ala Ile Met Leu Ala Met Thr Leu Ala -15 -10
-5 -1 Leu Gly Thr Leu Pro Ala Phe Leu Pro Cys Glu Leu Gln Pro His
Gly 1 5 10 15 Leu Val Asn Cys Asn Trp Leu Phe Leu Lys Ser Val Pro
His Phe Ser 20 25 30 Met Ala Ala Pro Arg Gly Asn Val Thr Ser Leu
Ser Leu Ser Ser Asn 35 40 45 Arg Ile His His Leu His Asp Ser Asp
Phe Ala His Leu Pro Ser Leu 50 55 60 Arg His Leu Asn Leu Lys Trp
Asn Cys Pro Pro Val Gly Leu Ser Pro 65 70 75 80 Met His Phe Pro Cys
His Met Thr Ile Glu Pro Ser Thr Phe Leu Ala 85 90 95 Val Pro Thr
Leu Glu Glu Leu Asn Leu Ser Tyr Asn Asn Ile Met Thr 100 105 110 Val
Pro Ala Leu Pro Lys Ser Leu Ile Ser Leu Ser Leu Ser His Thr 115 120
125 Asn Ile Leu Met Leu Asp Ser Ala Ser Leu Ala Gly Leu His Ala Leu
130 135 140 Arg Phe Leu Phe Met Asp Gly Asn Cys Tyr Tyr Lys Asn Pro
Cys Arg 145 150 155 160 Gln Ala Leu Glu Val Ala Pro Gly Ala Leu Leu
Gly Leu Gly Asn Leu 165 170 175 Thr His Leu Ser Leu Lys Tyr Asn Asn
Leu Thr Val Val Pro Arg Asn 180 185 190 Leu Pro Ser Ser Leu Glu Tyr
Leu Leu Leu Ser Tyr Asn Arg Ile Val 195 200 205 Lys Leu Ala Pro Glu
Asp Leu Ala Asn Leu Thr Ala Leu Arg Val Leu 210 215 220 Asp Val Gly
Gly Asn Cys Arg Arg Cys Asp His Ala Pro Asn Pro Cys 225 230 235 240
Met Glu Cys Pro Arg His Phe Pro Gln Leu His Pro Asp Thr Phe Ser 245
250 255 His Leu Ser Arg Leu Glu Gly Leu Val Leu Lys Asp Ser Ser Leu
Ser 260 265 270 Trp Leu Asn Ala Ser Trp Phe Arg Gly Leu Gly Asn Leu
Arg Val Leu 275 280 285 Asp Leu Ser Glu Asn Phe Leu Tyr Lys Cys Ile
Thr Lys Thr Lys Ala 290 295 300 Phe Gln Gly Leu Thr Gln Leu Arg Lys
Leu Asn Leu Ser Phe Asn Tyr 305 310 315 320 Gln Lys Arg Val Ser Phe
Ala His Leu Ser Leu Ala Pro Ser Phe Gly 325 330 335 Ser Leu Val Ala
Leu Lys Glu Leu Asp Met His Gly Ile Phe Phe Arg 340 345 350 Ser Leu
Asp Glu Thr Thr Leu Arg Pro Leu Ala Arg Leu Pro Met Leu 355 360 365
Gln Thr Leu Arg Leu Gln Met Asn Phe Ile Asn Gln Ala Gln Leu Gly 370
375 380 Ile Phe Arg Ala Phe Pro Gly Leu Arg Tyr Val Asp Leu Ser Asp
Asn 385 390 395 400 Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met
Gly Glu Ala Asp 405 410 415 Gly Gly Glu Lys Val Trp Leu Gln Pro Gly
Asp Leu Ala Pro Ala Pro 420 425 430 Val Asp Thr Pro Ser Ser Glu Asp
Phe Arg Pro Asn Cys Ser Thr Leu 435 440 445 Asn Phe Thr Leu Asp Leu
Ser Arg Asn Asn Leu Val Thr Val Gln Pro 450 455 460 Glu Met Phe Ala
Gln Leu Ser His Leu Gln Cys Leu Arg Leu Ser His 465 470 475 480 Asn
Cys Ile Ser Gln Ala Val Asn Gly Ser Gln Phe Leu Pro Leu Thr 485 490
495 Gly Leu Gln Val Leu Asp Leu Ser His Asn Lys Leu Asp Leu Tyr His
500 505 510 Glu His Ser Phe Thr Glu Leu Pro Arg Leu Glu Ala Leu Asp
Leu Ser 515 520 525 Tyr Asn Ser Gln Pro Phe Gly Met Gln Gly Val Gly
His Asn Phe Ser 530 535 540 Phe Val Ala His Leu Arg Thr Leu Arg His
Leu Ser Leu Ala His Asn 545 550 555 560 Asn Ile His Ser Gln Val Ser
Gln Gln Leu Cys Ser Thr Ser Leu Arg 565 570 575 Ala Leu Asp Phe Ser
Gly Asn Ala Leu Gly His Met Trp Ala Glu Gly 580 585 590 Asp Leu Tyr
Leu His Phe Phe Gln Gly Leu Ser Gly Leu Ile Trp Leu 595 600 605 Asp
Leu Ser Gln Asn Arg Leu His Thr Leu Leu Pro Gln Thr Leu Arg 610 615
620 Asn Leu Pro Lys Ser Leu Gln Val Leu Arg Leu Arg Asp Asn Tyr Leu
625 630 635 640 Ala Phe Phe Lys Trp Trp Ser Leu His Phe Leu Pro Lys
Leu Glu Val 645 650 655 Leu Asp Leu Ala Gly Asn Gln Leu Lys Ala Leu
Thr Asn Gly Ser Leu 660 665 670 Pro Ala Gly Thr Arg Leu Arg Arg Leu
Asp Val Ser Cys Asn Ser Ile 675 680 685 Ser Phe Val Ala Pro Gly Phe
Phe Ser Lys Ala Lys Glu Leu Arg Glu 690 695 700 Leu Asn Leu Ser Ala
Asn Ala Leu Lys Thr Val Asp His Ser Trp Phe 705 710 715 720 Gly Pro
Leu Ala Ser Ala Leu Gln Ile Leu Asp Val Ser Ala Asn Pro 725 730 735
Leu His Cys Ala Cys Gly Ala Ala Phe Met Asp Phe Leu Leu Glu Val 740
745 750 Gln Ala Ala Val Pro Gly Leu Pro Ser Arg Val Lys Cys Gly Ser
Pro 755 760 765 Gly Gln Leu Gln Gly Leu Ser Ile Phe Ala Gln Asp Leu
Arg Leu Cys 770 775 780 Leu Asp Glu Ala Leu Ser Trp Asp Cys Phe Ala
Leu Ser Leu Leu Ala 785 790 795 800 Val Ala Leu Gly Leu Gly Val Pro
Met Leu His His Leu Cys Gly Trp 805 810 815 Asp Leu Trp Tyr Cys Phe
His Leu Cys Leu Ala Trp Leu Pro Trp Arg 820 825 830 Gly Arg Gln Ser
Gly Arg Asp Glu Asp Ala Leu Pro Tyr Asp Ala Phe 835 840 845 Val Val
Phe Asp Lys Thr Gln Ser Ala Val Ala Asp Trp Val Tyr Asn 850 855 860
Glu Leu Arg Gly Gln Leu Glu Glu Cys Arg Gly Arg Trp Ala Leu Arg 865
870 875 880 Leu Cys Leu Glu Glu Arg Asp Trp Leu Pro Gly Lys Thr Leu
Phe Glu 885 890 895 Asn Leu Trp Ala Ser Val Tyr Gly Ser Arg Lys Thr
Leu Phe Val Leu 900 905 910 Ala His Thr Asp Arg Val Ser Gly Leu Leu
Arg Ala Ser Phe Leu Leu 915 920 925 Ala Gln Gln Arg Leu Leu Glu Asp
Arg Lys Asp Val Val Val Leu Val 930 935 940 Ile Leu Ser Pro Asp Gly
Arg Arg Ser Arg Tyr Val Arg Leu Arg Gln 945 950 955 960
Arg Leu Cys Arg Gln Ser Val Leu Leu Trp Pro His Gln Pro Ser Gly 965
970 975 Gln Arg Ser Phe Trp Ala Gln Leu Gly Met Ala Leu Thr Arg Asp
Asn 980 985 990 His His Phe Tyr Asn Arg Asn Phe Cys Gln Gly Pro Thr
Ala Glu 995 1000 1005 <210> SEQ ID NO 44 <211> LENGTH:
2289 <212> TYPE: DNA <213> ORGANISM: Mus musculus
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(2079) <400> SEQUENCE: 44 aac ctg tcc ttc aat
tac cgc aag aag gta tcc ttt gcc cgc ctc cac 48 Asn Leu Ser Phe Asn
Tyr Arg Lys Lys Val Ser Phe Ala Arg Leu His 1 5 10 15 ctg gca agt
tcc ttt aag aac ctg gtg tca ctg cag gag ctg aac atg 96 Leu Ala Ser
Ser Phe Lys Asn Leu Val Ser Leu Gln Glu Leu Asn Met 20 25 30 aac
ggc atc ttc ttc cgc ttg ctc aac aag tac acg ctc aga tgg ctg 144 Asn
Gly Ile Phe Phe Arg Leu Leu Asn Lys Tyr Thr Leu Arg Trp Leu 35 40
45 gcc gat ctg ccc aaa ctc cac act ctg cat ctt caa atg aac ttc atc
192 Ala Asp Leu Pro Lys Leu His Thr Leu His Leu Gln Met Asn Phe Ile
50 55 60 aac cag gca cag ctc agc atc ttt ggt acc ttc cga gcc ctt
cgc ttt 240 Asn Gln Ala Gln Leu Ser Ile Phe Gly Thr Phe Arg Ala Leu
Arg Phe 65 70 75 80 gtg gac ttg tca gac aat cgc atc agt ggg cct tca
acg ctg tca gaa 288 Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Pro Ser
Thr Leu Ser Glu 85 90 95 gcc acc cct gaa gag gca gat gat gca gag
cag gag gag ctg ttg tct 336 Ala Thr Pro Glu Glu Ala Asp Asp Ala Glu
Gln Glu Glu Leu Leu Ser 100 105 110 gcg gat cct cac cca gct ccg ctg
agc acc cct gct tct aag aac ttc 384 Ala Asp Pro His Pro Ala Pro Leu
Ser Thr Pro Ala Ser Lys Asn Phe 115 120 125 atg gac agg tgt aag aac
ttc aag ttc aac atg gac ctg tct cgg aac 432 Met Asp Arg Cys Lys Asn
Phe Lys Phe Asn Met Asp Leu Ser Arg Asn 130 135 140 aac ctg gtg act
atc aca gca gag atg ttt gta aat ctc tca cgc ctc 480 Asn Leu Val Thr
Ile Thr Ala Glu Met Phe Val Asn Leu Ser Arg Leu 145 150 155 160 cag
tgt ctt agc ctg agc cac aac tca att gca cag gct gtc aat ggc 528 Gln
Cys Leu Ser Leu Ser His Asn Ser Ile Ala Gln Ala Val Asn Gly 165 170
175 tct cag ttc ctg ccg ctg acc ggt ctg cag gtg cta gac ctg tcc cac
576 Ser Gln Phe Leu Pro Leu Thr Gly Leu Gln Val Leu Asp Leu Ser His
180 185 190 aat aag ctg gac ctc tac cac gag cac tca ttc acg gag cta
cca cga 624 Asn Lys Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu
Pro Arg 195 200 205 ctg gag gcc ctg gac ctc agc tac aac agc cag ccc
ttt agc atg aag 672 Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro
Phe Ser Met Lys 210 215 220 ggt ata ggc cac aat ttc agt ttt gtg acc
cat ctg tcc atg cta cag 720 Gly Ile Gly His Asn Phe Ser Phe Val Thr
His Leu Ser Met Leu Gln 225 230 235 240 agc ctt agc ctg gca cac aat
gac att cat acc cgt gtg tcc tca cat 768 Ser Leu Ser Leu Ala His Asn
Asp Ile His Thr Arg Val Ser Ser His 245 250 255 ctc aac agc aac tca
gtg agg ttt ctt gac ttc agc ggc aac ggt atg 816 Leu Asn Ser Asn Ser
Val Arg Phe Leu Asp Phe Ser Gly Asn Gly Met 260 265 270 ggc cgc atg
tgg gat gag ggg ggc ctt tat ctc cat ttc ttc caa ggc 864 Gly Arg Met
Trp Asp Glu Gly Gly Leu Tyr Leu His Phe Phe Gln Gly 275 280 285 ctg
agt ggc gtg ctg aag ctg gac ctg tct caa aat aac ctg cat atc 912 Leu
Ser Gly Val Leu Lys Leu Asp Leu Ser Gln Asn Asn Leu His Ile 290 295
300 ctc cgg ccc cag aac ctt gac aac ctc ccc aag agc ctg aag ctg ctg
960 Leu Arg Pro Gln Asn Leu Asp Asn Leu Pro Lys Ser Leu Lys Leu Leu
305 310 315 320 agc ctc cga gac aac tac cta tct ttc ttt aac tgg acc
agt ctg tcc 1008 Ser Leu Arg Asp Asn Tyr Leu Ser Phe Phe Asn Trp
Thr Ser Leu Ser 325 330 335 ttc cta ccc aac ctg gaa gtc cta gac ctg
gca ggc aac cag cta aag 1056 Phe Leu Pro Asn Leu Glu Val Leu Asp
Leu Ala Gly Asn Gln Leu Lys 340 345 350 gcc ctg acc aat ggc acc ctg
cct aat ggc acc ctc ctc cag aaa ctc 1104 Ala Leu Thr Asn Gly Thr
Leu Pro Asn Gly Thr Leu Leu Gln Lys Leu 355 360 365 gat gtc agt agc
aac agt atc gtc tct gtg gcc ccc ggc ttc ttt tcc 1152 Asp Val Ser
Ser Asn Ser Ile Val Ser Val Ala Pro Gly Phe Phe Ser 370 375 380 aag
gcc aag gag ctg cga gag ctc aac ctt agc gcc aac gcc ctc aag 1200
Lys Ala Lys Glu Leu Arg Glu Leu Asn Leu Ser Ala Asn Ala Leu Lys 385
390 395 400 aca gtg gac cac tcc tgg ttt ggg ccc att gtg atg aac ctg
aca gtt 1248 Thr Val Asp His Ser Trp Phe Gly Pro Ile Val Met Asn
Leu Thr Val 405 410 415 cta gac gtg aga agc aac cct ctg cac tgt gcc
tgt ggg gca gcc ttc 1296 Leu Asp Val Arg Ser Asn Pro Leu His Cys
Ala Cys Gly Ala Ala Phe 420 425 430 gta gac tta ctg ttg gag gtg cag
acc aag gtg cct ggc ctg gct aat 1344 Val Asp Leu Leu Leu Glu Val
Gln Thr Lys Val Pro Gly Leu Ala Asn 435 440 445 ggt gtg aag tgt ggc
agc ccc ggc cag ctg cag ggc cgt agc atc ttc 1392 Gly Val Lys Cys
Gly Ser Pro Gly Gln Leu Gln Gly Arg Ser Ile Phe 450 455 460 gcg cag
gac ctg cgg ctg tgc ctg gat gag gtc ctc tct tgg gac tgc 1440 Ala
Gln Asp Leu Arg Leu Cys Leu Asp Glu Val Leu Ser Trp Asp Cys 465 470
475 480 ttt ggc ctt tca ctc ttg gct gtg gcc gtg ggc atg gtg gtg cct
ata 1488 Phe Gly Leu Ser Leu Leu Ala Val Ala Val Gly Met Val Val
Pro Ile 485 490 495 ctg cac cat ctc tgc ggc tgg gac gtc tgg tac tgt
ttt cat ctg tgc 1536 Leu His His Leu Cys Gly Trp Asp Val Trp Tyr
Cys Phe His Leu Cys 500 505 510 ctg gca tgg cta cct ttg cta gcc cgc
agc cga cgc agc gcc caa act 1584 Leu Ala Trp Leu Pro Leu Leu Ala
Arg Ser Arg Arg Ser Ala Gln Thr 515 520 525 ctc cct tat gat gcc ttc
gtg gtg ttc gat aag gca cag agc gca gtt 1632 Leu Pro Tyr Asp Ala
Phe Val Val Phe Asp Lys Ala Gln Ser Ala Val 530 535 540 gcc gac tgg
gtg tat aac gag ctg cgg gtg cgg ctg gag gag cgg cgc 1680 Ala Asp
Trp Val Tyr Asn Glu Leu Arg Val Arg Leu Glu Glu Arg Arg 545 550 555
560 ggc cgc tgg gca ctc cgc ctg tgc ctg gag gac cga gat tgg ctg cct
1728 Gly Arg Trp Ala Leu Arg Leu Cys Leu Glu Asp Arg Asp Trp Leu
Pro 565 570 575 ggc cag acg ctc ttc gag aac ctc tgg gct tcc atc tat
ggg agc cgc 1776 Gly Gln Thr Leu Phe Glu Asn Leu Trp Ala Ser Ile
Tyr Gly Ser Arg 580 585 590 aag act cta ttt gtg ctg gcc cac acg gac
cgc gtc agt ggc ctc ctg 1824 Lys Thr Leu Phe Val Leu Ala His Thr
Asp Arg Val Ser Gly Leu Leu 595 600 605 cgc acc agc ttc ctg ctg gct
cag cag cgc ctg ttg gaa gac cgc aag 1872 Arg Thr Ser Phe Leu Leu
Ala Gln Gln Arg Leu Leu Glu Asp Arg Lys 610 615 620 gac gtg gtg gtg
ttg gtg atc ctg cgt ccg gat gcc cac cgc tcc cgc 1920 Asp Val Val
Val Leu Val Ile Leu Arg Pro Asp Ala His Arg Ser Arg 625 630 635 640
tat gtg cga ctg cgc cag cgt ctc tgc cgc cag agt gtg ctc ttc tgg
1968 Tyr Val Arg Leu Arg Gln Arg Leu Cys Arg Gln Ser Val Leu Phe
Trp 645 650 655 ccc cag cag ccc aac ggg cag ggg ggc ttc tgg gcc cag
ctg agt aca 2016 Pro Gln Gln Pro Asn Gly Gln Gly Gly Phe Trp Ala
Gln Leu Ser Thr 660 665 670 gcc ctg act agg gac aac cgc cac ttc tat
aac cag aac ttc tgc cgg 2064 Ala Leu Thr Arg Asp Asn Arg His Phe
Tyr Asn Gln Asn Phe Cys Arg 675 680 685 gga cct aca gca gaa
tagctcagag caacagctgg aaacagctgc atcttcatgt 2119 Gly Pro Thr Ala
Glu 690 ctggttcccg agttgctctg cctgccttgc tctgtcttac tacaccgcta
tttggcaagt 2179 gcgcaatata tgctaccaag ccaccaggcc cacggagcaa
aggttggctg taaagggtag 2239 ttttcttccc atgcatcttt caggagagtg
aagatagaca ccaaacccac 2289 <210> SEQ ID NO 45 <211>
LENGTH: 693 <212> TYPE: PRT <213> ORGANISM: Mus
musculus <400> SEQUENCE: 45 Asn Leu Ser Phe Asn Tyr Arg Lys
Lys Val Ser Phe Ala Arg Leu His 1 5 10 15 Leu Ala Ser Ser Phe Lys
Asn Leu Val Ser Leu Gln Glu Leu Asn Met 20 25 30 Asn Gly Ile Phe
Phe Arg Leu Leu Asn Lys Tyr Thr Leu Arg Trp Leu 35 40 45 Ala Asp
Leu Pro Lys Leu His Thr Leu His Leu Gln Met Asn Phe Ile 50 55 60
Asn Gln Ala Gln Leu Ser Ile Phe Gly Thr Phe Arg Ala Leu Arg Phe 65
70 75 80 Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Pro Ser Thr Leu
Ser Glu 85 90 95 Ala Thr Pro Glu Glu Ala Asp Asp Ala Glu Gln Glu
Glu Leu Leu Ser 100 105 110 Ala Asp Pro His Pro Ala Pro Leu Ser Thr
Pro Ala Ser Lys Asn Phe 115 120 125 Met Asp Arg Cys Lys Asn Phe Lys
Phe Asn Met Asp Leu Ser Arg Asn 130 135 140 Asn Leu Val Thr Ile Thr
Ala Glu Met Phe Val Asn Leu Ser Arg Leu 145 150 155 160 Gln Cys Leu
Ser Leu Ser His Asn Ser Ile Ala Gln Ala Val Asn Gly 165 170 175 Ser
Gln Phe Leu Pro Leu Thr Gly Leu Gln Val Leu Asp Leu Ser His 180 185
190 Asn Lys Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu Pro Arg
195 200 205 Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro Phe Ser
Met Lys
210 215 220 Gly Ile Gly His Asn Phe Ser Phe Val Thr His Leu Ser Met
Leu Gln 225 230 235 240 Ser Leu Ser Leu Ala His Asn Asp Ile His Thr
Arg Val Ser Ser His 245 250 255 Leu Asn Ser Asn Ser Val Arg Phe Leu
Asp Phe Ser Gly Asn Gly Met 260 265 270 Gly Arg Met Trp Asp Glu Gly
Gly Leu Tyr Leu His Phe Phe Gln Gly 275 280 285 Leu Ser Gly Val Leu
Lys Leu Asp Leu Ser Gln Asn Asn Leu His Ile 290 295 300 Leu Arg Pro
Gln Asn Leu Asp Asn Leu Pro Lys Ser Leu Lys Leu Leu 305 310 315 320
Ser Leu Arg Asp Asn Tyr Leu Ser Phe Phe Asn Trp Thr Ser Leu Ser 325
330 335 Phe Leu Pro Asn Leu Glu Val Leu Asp Leu Ala Gly Asn Gln Leu
Lys 340 345 350 Ala Leu Thr Asn Gly Thr Leu Pro Asn Gly Thr Leu Leu
Gln Lys Leu 355 360 365 Asp Val Ser Ser Asn Ser Ile Val Ser Val Ala
Pro Gly Phe Phe Ser 370 375 380 Lys Ala Lys Glu Leu Arg Glu Leu Asn
Leu Ser Ala Asn Ala Leu Lys 385 390 395 400 Thr Val Asp His Ser Trp
Phe Gly Pro Ile Val Met Asn Leu Thr Val 405 410 415 Leu Asp Val Arg
Ser Asn Pro Leu His Cys Ala Cys Gly Ala Ala Phe 420 425 430 Val Asp
Leu Leu Leu Glu Val Gln Thr Lys Val Pro Gly Leu Ala Asn 435 440 445
Gly Val Lys Cys Gly Ser Pro Gly Gln Leu Gln Gly Arg Ser Ile Phe 450
455 460 Ala Gln Asp Leu Arg Leu Cys Leu Asp Glu Val Leu Ser Trp Asp
Cys 465 470 475 480 Phe Gly Leu Ser Leu Leu Ala Val Ala Val Gly Met
Val Val Pro Ile 485 490 495 Leu His His Leu Cys Gly Trp Asp Val Trp
Tyr Cys Phe His Leu Cys 500 505 510 Leu Ala Trp Leu Pro Leu Leu Ala
Arg Ser Arg Arg Ser Ala Gln Thr 515 520 525 Leu Pro Tyr Asp Ala Phe
Val Val Phe Asp Lys Ala Gln Ser Ala Val 530 535 540 Ala Asp Trp Val
Tyr Asn Glu Leu Arg Val Arg Leu Glu Glu Arg Arg 545 550 555 560 Gly
Arg Trp Ala Leu Arg Leu Cys Leu Glu Asp Arg Asp Trp Leu Pro 565 570
575 Gly Gln Thr Leu Phe Glu Asn Leu Trp Ala Ser Ile Tyr Gly Ser Arg
580 585 590 Lys Thr Leu Phe Val Leu Ala His Thr Asp Arg Val Ser Gly
Leu Leu 595 600 605 Arg Thr Ser Phe Leu Leu Ala Gln Gln Arg Leu Leu
Glu Asp Arg Lys 610 615 620 Asp Val Val Val Leu Val Ile Leu Arg Pro
Asp Ala His Arg Ser Arg 625 630 635 640 Tyr Val Arg Leu Arg Gln Arg
Leu Cys Arg Gln Ser Val Leu Phe Trp 645 650 655 Pro Gln Gln Pro Asn
Gly Gln Gly Gly Phe Trp Ala Gln Leu Ser Thr 660 665 670 Ala Leu Thr
Arg Asp Asn Arg His Phe Tyr Asn Gln Asn Phe Cys Arg 675 680 685 Gly
Pro Thr Ala Glu 690 <210> SEQ ID NO 46 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic primer <400> SEQUENCE: 46
cgtaaaactg gaagctttgc aaga 24 <210> SEQ ID NO 47 <211>
LENGTH: 24 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic primer <400>
SEQUENCE: 47 ccttgggcca ttccaaataa gtcc 24 <210> SEQ ID NO 48
<211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic primer
<400> SEQUENCE: 48 ggccagcaaa ttacctgtgt g 21 <210> SEQ
ID NO 49 <211> LENGTH: 21 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
primer <400> SEQUENCE: 49 ccaggtaggt cttggtgttc a 21
<210> SEQ ID NO 50 <211> LENGTH: 25 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 50 attgggtctg ggaacatttc
tcttc 25 <210> SEQ ID NO 51 <211> LENGTH: 25
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic primer <400> SEQUENCE: 51
gtgagattta aacattcctc ttcgc 25 <210> SEQ ID NO 52 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic primer <400>
SEQUENCE: 52 ctgcaatgga tcaaggacca 20 <210> SEQ ID NO 53
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic primer
<400> SEQUENCE: 53 tcccactcca ggtaagtgtt 20 <210> SEQ
ID NO 54 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
primer <400> SEQUENCE: 54 cattgtatgc actgtcactc 20
<210> SEQ ID NO 55 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 55 ccaccaccat gatgagagca 20
<210> SEQ ID NO 56 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 56 taggtctcat gacgaaggat 20
<210> SEQ ID NO 57 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic primer <400> SEQUENCE: 57
ggccactgca aataagtccg 20 <210> SEQ ID NO 58 <211>
LENGTH: 18 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic primer <400>
SEQUENCE: 58 agtgtctaaa gaacctgg 18 <210> SEQ ID NO 59
<211> LENGTH: 18 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic primer
<400> SEQUENCE: 59 cttggcctta cagaaatg 18 <210> SEQ ID
NO 60 <211> LENGTH: 24 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
primer <400> SEQUENCE: 60 cagaatagca ggcgtaacac atca 24
<210> SEQ ID NO 61 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 61 aatgtcacag gtgcattcaa
aggg 24 <210> SEQ ID NO 62 <211> LENGTH: 24 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic primer <400> SEQUENCE: 62 ttatggactt
cctgctggag gtgc 24 <210> SEQ ID NO 63 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic primer <400> SEQUENCE: 63
ctgcgttttg tcgaagacca 20 <210> SEQ ID NO 64 <211>
LENGTH: 24 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic primer <400>
SEQUENCE: 64 caatctagag aaggaagatg gtcc 24 <210> SEQ ID NO 65
<211> LENGTH: 24 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic primer
<400> SEQUENCE: 65 gcccttataa acttgtgaag gtgt 24 <210>
SEQ ID NO 66 <211> LENGTH: 32 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 66 atctggcacc acaccttcta
caatgagctg cg 32 <210> SEQ ID NO 67 <211> LENGTH: 32
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic primer <400> SEQUENCE: 67
cgtcatactc ctgcttgctg atccacatct gc 32 <210> SEQ ID NO 68
<211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic primer
<400> SEQUENCE: 68 ggccagcaaa ttacctgtgt g 21 <210> SEQ
ID NO 69 <211> LENGTH: 19 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
primer <400> SEQUENCE: 69 aggcggacat cctgaacct 19 <210>
SEQ ID NO 70 <211> LENGTH: 20 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 70 ctgcaatgga tcaaggacca 20
<210> SEQ ID NO 71 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 71 ttatctgaag gtgttgcaca
ttcc 24 <210> SEQ ID NO 72 <211> LENGTH: 24 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic primer <400> SEQUENCE: 72 ttacctggat
ggaaaccagc tact 24 <210> SEQ ID NO 73 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic primer <400> SEQUENCE: 73
tcaaggctga gaagctgtaa gcta 24 <210> SEQ ID NO 74 <211>
LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic primer <400>
SEQUENCE: 74 tgaagacttc aggcccaact g 21 <210> SEQ ID NO 75
<211> LENGTH: 19 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic primer <400> SEQUENCE: 75 tgcacggtca ccaggttgt 19
<210> SEQ ID NO 76 <211> LENGTH: 161 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 76 Thr
Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu Cys 1 5 10
15 Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu Pro
20 25 30 Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe
Glu Arg 35 40 45 Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile
His Ser Leu Ile 50 55 60 Glu Lys Ser Arg Arg Leu Ile Ile Val Leu
Ser Lys Ser Tyr Met Ser 65 70 75 80 Asn Glu Val Arg Tyr Glu Leu Glu
Ser Gly Leu His Glu Ala Leu Val 85 90 95 Glu Arg Lys Ile Ile Ile
Leu Ile Glu Phe Thr Pro Val Thr Asp Phe 100 105 110 Thr Phe Leu Pro
Gln Ser Leu Lys Leu Leu Lys Ser His Arg Val Leu 115 120 125 Lys Trp
Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe Trp Lys 130 135 140
Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly Arg Asp 145
150 155 160 Glu <210> SEQ ID NO 77 <211> LENGTH: 158
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 77 Leu Asp Gly Lys Glu Tyr Asp Ile Tyr Val
Ser Tyr Ala Arg Asn Val 1 5 10 15 Glu Glu Glu Glu Phe Val Leu Leu
Thr Leu Arg Gly Val Leu Glu Asn 20 25 30 Glu Phe Gly Tyr Lys Leu
Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly 35 40 45 Gly Ile Val Thr
Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg 50 55 60 Leu Leu
Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala 65 70 75 80
Leu Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn 85
90 95 Ile Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Asp Met Lys
Val 100 105 110 Lys Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile
Lys Trp Lys 115 120 125 Gly Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe
Trp Lys Gln Leu Gln 130 135 140 Val Ala Met Pro Val Lys Lys Ser Pro
Arg Trp Ser Ser Asn 145 150 155 <210> SEQ ID NO 78
<211> LENGTH: 175 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 78 Asn Asp Gly Lys Leu Tyr Asp
Ala Tyr Ile Ile Tyr Pro Arg Val Phe 1 5 10 15 Arg Gly Ser Ala Ala
Gly Thr His Ser Val Glu Tyr Phe Val His His 20 25 30 Thr Leu Pro
Asp Val Leu Glu Asn Lys Cys Gly Tyr Lys Leu Cys Ile 35 40 45 Tyr
Gly Arg Asp Leu Leu Pro Gly Gln Asp Ala Ala Thr Val Val Glu 50 55
60 Ser Ser Ile Gln Asn Ser Arg Arg Gln Val Phe Val Leu Ala Pro His
65 70 75 80 Met Met His Ser Lys Glu Phe Ala Tyr Glu Gln Glu Ile Ala
Leu His 85 90 95 Ser Ala Leu Ile Gln Asn Asn Ser Lys Val Ile Leu
Ile Glu Met Glu 100 105 110 Pro Leu Gly Glu Ala Ser Arg Leu Gln Val
Gly Asp Leu Gln Asp Ser 115 120 125 Leu Gln His Leu Val Lys Ile Gln
Gly Thr Ile Lys Trp Arg Glu Asp 130 135 140 His Val Ala Asp Lys Gln
Ser Leu Ser Ser Lys Phe Trp Lys His Val 145 150 155 160 Arg Tyr Gln
Met Pro Val Pro Glu Arg Ala Ser Lys Thr Ala Ser 165 170 175
<210> SEQ ID NO 79 <211> LENGTH: 170 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 79 Val
Asp Gly Lys Leu Tyr Asp Ala Tyr Val Leu Tyr Pro Lys Pro His 1 5 10
15 Lys Glu Ser Gln Arg His Ala Val Asp Ala Leu Val Leu Asn Ile Leu
20 25 30 Pro Glu Val Leu Glu Arg Gln Cys Gly Tyr Lys Leu Phe Ile
Phe Gly 35 40 45 Arg Asp Glu Phe Pro Gly Gln Ala Val Ala Asn Val
Ile Asp Glu Asn 50 55 60 Val Lys Leu Cys Arg Arg Leu Ile Val Ile
Val Val Pro Glu Ser Leu 65 70 75 80 Gly Phe Gly Leu Leu Lys Asn Leu
Ser Glu Glu Gln Ile Ala Val Tyr 85 90 95 Ser Ala Leu Ile Gln Asp
Gly Met Lys Val Ile Leu Ile Glu Leu Glu 100 105 110 Lys Ile Glu Asp
Tyr Thr Val Met Pro Glu Ser Ile Gln Tyr Ile Lys 115 120 125 Gln Lys
His Gly Ala Ile Arg Trp His Gly Asp Phe Thr Glu Gln Ser 130 135 140
Gln Cys Met Lys Thr Lys Phe Trp Lys Thr Val Arg Tyr His Met Pro 145
150 155 160 Pro Arg Arg Cys Arg Pro Phe Leu Arg Ser 165 170
<210> SEQ ID NO 80 <211> LENGTH: 170 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 80 Ser
Asp Gly Lys Thr Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val 1 5 10
15 Gly Glu Gly Ser Thr Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu
20 25 30 Pro Glu Val Leu Glu Lys Gln Cys Gly Tyr Lys Leu Phe Ile
Tyr Gly 35 40 45 Arg Asp Asp Tyr Val Gly Glu Asp Ile Val Glu Val
Ile Asn Glu Asn 50 55 60 Val Lys Lys Ser Arg Arg Leu Ile Ile Ile
Leu Val Arg Glu Thr Ser 65 70 75 80 Gly Phe Ser Trp Leu Gly Gly Ser
Ser Glu Glu Gln Ile Ala Met Tyr 85 90 95 Asn Ala Leu Val Gln Asp
Gly Ile Lys Val Val Leu Leu Glu Leu Glu 100 105 110 Lys Ile Gln Asp
Tyr Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys 115 120 125 Gln Lys
His Gly Ala Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro 130 135 140
Gln Ser Ala Lys Thr Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro 145
150 155 160 Val Gln Arg Arg Ser Pro Ser Ser Lys His 165 170
<210> SEQ ID NO 81 <211> LENGTH: 169 <212> TYPE:
PRT <213> ORGANISM: Gallus gallus <400> SEQUENCE: 81
Ser Asp Gly Lys Ile Tyr Asp Ala Tyr Val Leu Tyr Pro Lys Asn Arg 1 5
10 15 Glu Ser Cys Leu Tyr Ser Ser Asp Ile Phe Ala Leu Lys Ile Leu
Pro 20 25 30 Glu Val Leu Glu Arg Gln Cys Gly Tyr Asn Leu Phe Ile
Phe Gly Arg 35 40 45 Asn Asp Leu Ala Gly Glu Ala Val Ile Asp Val
Thr Asp Glu Lys Ile 50 55 60 His Gln Ser Arg Arg Val Ile Ile Ile
Leu Val Pro Glu Pro Ser Cys 65 70 75 80 Tyr Gly Ile Leu Glu Asp Ala
Ser Glu Lys His Leu Ala Val Tyr Asn 85 90 95 Ala Leu Ile Gln Asp
Gly Ile Lys Ile Ile Leu Ile Glu Leu Glu Lys 100 105 110 Ile Glu Asp
Tyr Ala Asn Met Pro Glu Ser Ile Lys Tyr Val Lys Gln 115 120 125 Lys
Tyr Gly Ala Ile Arg Trp Thr Gly Asp Phe Ser Glu Arg Ser His 130 135
140 Ser Ala Ser Thr Arg Phe Trp Lys Lys Val Arg Tyr His Met Pro Ser
145 150 155 160 Arg Lys His Gly Ser Ser Ser Gly Phe 165 <210>
SEQ ID NO 82
<211> LENGTH: 140 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 82 His Met Pro Glu Arg Phe Asp
Ala Phe Ile Cys Tyr Cys Pro Ser Asp 1 5 10 15 Ile Gln Phe Val Gln
Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr 20 25 30 Arg Leu Lys
Leu Cys Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys 35 40 45 Val
Trp Ser Ile Ala Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met 50 55
60 Val Val Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe
65 70 75 80 Gln Thr Lys Phe Ala Leu Ser Leu Ser Pro Gly Ala His Gln
Lys Leu 85 90 95 Ile Pro Ile Lys Tyr Lys Ala Met Lys Lys Glu Phe
Pro Ser Ile Leu 100 105 110 Arg Phe Ile Thr Val Cys Asp Tyr Thr Asn
Pro Cys Thr Lys Ser Trp 115 120 125 Phe Trp Thr Arg Leu Ala Lys Ala
Leu Ser Leu Pro 130 135 140 <210> SEQ ID NO 83 <211>
LENGTH: 140 <212> TYPE: PRT <213> ORGANISM: Mus
musculus <400> SEQUENCE: 83 Gln Thr Pro Glu Leu Phe Asp Ala
Phe Ile Cys Tyr Cys Pro Asn Asp 1 5 10 15 Ile Glu Phe Val Gln Glu
Met Ile Arg Gln Leu Glu Gln Thr Asp Tyr 20 25 30 Arg Leu Lys Leu
Cys Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys 35 40 45 Val Trp
Ser Ile Ala Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met 50 55 60
Val Val Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe 65
70 75 80 Gln Thr Lys Phe Ala Leu Ser Leu Ser Pro Gly Val Gln Gln
Lys Leu 85 90 95 Ile Pro Ile Lys Tyr Lys Ala Met Lys Lys Asp Phe
Pro Ser Ile Leu 100 105 110 Arg Phe Ile Thr Ile Cys Asp Tyr Thr Asn
Pro Cys Thr Lys Ser Trp 115 120 125 Phe Trp Thr Arg Leu Ala Lys Ala
Leu Ser Leu Pro 130 135 140 <210> SEQ ID NO 84 <211>
LENGTH: 154 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 84 Gln Arg Asn Leu Gln Phe His Ala
Phe Ile Ser Tyr Ser Gly His Asp 1 5 10 15 Ser Phe Trp Val Lys Asn
Glu Leu Leu Pro Asn Leu Glu Lys Glu Gly 20 25 30 Met Gln Ile Cys
Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile 35 40 45 Val Glu
Asn Ile Ile Thr Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe 50 55 60
Val Leu Ser Pro Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu 65
70 75 80 Tyr Phe Ala His His Asn Leu Phe His Glu Gly Ser Ser Leu
Ile Leu 85 90 95 Ile Leu Leu Glu Pro Ile Pro Gln Tyr Ser Ile Pro
Ser Ser Tyr His 100 105 110 Lys Leu Lys Ser Leu Met Ala Arg Arg Thr
Tyr Leu Glu Trp Pro Lys 115 120 125 Glu Lys Ser Lys Arg Gly Leu Phe
Trp Ala Asn Leu Arg Ala Ala Ile 130 135 140 Asn Ile Lys Leu Thr Glu
Gln Ala Lys Lys 145 150 <210> SEQ ID NO 85 <211>
LENGTH: 148 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 85 Ser Arg Asn Ile Cys Tyr Asp Ala
Phe Val Ser Tyr Ser Glu Arg Asp 1 5 10 15 Ala Tyr Trp Val Glu Asn
Leu Met Val Gln Glu Leu Glu Asn Phe Asn 20 25 30 Pro Pro Phe Lys
Leu Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys 35 40 45 Trp Ile
Ile Asp Asn Ile Ile Asp Ser Ile Glu Lys Thr Thr Lys Leu 50 55 60
Ser Phe Val Leu Ser Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr 65
70 75 80 Glu Leu Asp Phe Ser His Phe Arg Leu Phe Asp Glu Asn Asn
Ala Ala 85 90 95 Ile Leu Ile Leu Leu Glu Pro Ile Glu Lys Lys Ala
Ile Pro Gln Arg 100 105 110 Phe Cys Lys Leu Arg Lys Ile Met Asn Thr
Lys Thr Tyr Leu Glu Trp 115 120 125 Pro Met Asp Glu Ala Gln Arg Glu
Gly Phe Trp Val Asn Leu Arg Ala 130 135 140 Ala Ile Lys Ser 145
<210> SEQ ID NO 86 <211> LENGTH: 154 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 86 Thr
Glu Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr Lys Asp 1 5 10
15 Lys Asp Trp Val Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln
20 25 30 Ser Leu Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly
Val Phe 35 40 45 Glu Leu Glu Ala Ile Val Asn Ser Ile Lys Arg Ser
Arg Lys Ile Ile 50 55 60 Phe Val Ile Thr His His Leu Leu Lys Asp
Pro Leu Cys Lys Arg Phe 65 70 75 80 Lys Val His His Ala Val Gln Gln
Ala Ile Glu Gln Asn Leu Ser Ile 85 90 95 Ile Leu Val Phe Leu Glu
Glu Ile Pro Asp Tyr Lys Leu Asn His Ala 100 105 110 Leu Cys Leu Arg
Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp 115 120 125 Pro Val
Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val 130 135 140
Ala Leu Gly Ile Gln Lys Leu Cys Tyr Ile 145 150 <210> SEQ ID
NO 87 <211> LENGTH: 159 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 87 Arg Gly Glu Asn Ile
Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp 1 5 10 15 Glu Asp Trp
Val Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val 20 25 30 Pro
Pro Phe Gln Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val 35 40
45 Ala Ile Ala Ala Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys
50 55 60 Val Ile Val Val Val Ser Gln His Phe Ile Gln Ser Arg Trp
Cys Ile 65 70 75 80 Phe Glu Tyr Glu Ile Ala Gln Thr Trp Gln Phe Leu
Ser Ser Arg Ala 85 90 95 Gly Ile Ile Phe Ile Val Leu Gln Lys Val
Glu Lys Thr Leu Leu Arg 100 105 110 Gln Gln Val Glu Leu Tyr Arg Leu
Leu Ser Arg Asn Thr Tyr Leu Leu 115 120 125 Glu Trp Glu Asp Ser Val
Leu Gly Arg His Ile Phe Trp Arg Arg Leu 130 135 140 Arg Lys Ala Leu
Leu Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr 145 150 155 <210>
SEQ ID NO 88 <211> LENGTH: 160 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 88 Pro Asp
Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp 1 5 10 15
Phe Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr 20
25 30 Ser Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe
Val 35 40 45 Pro Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile
Trp Asn Ser 50 55 60 Arg Lys Ile Val Cys Leu Val Ser Arg His Phe
Leu Arg Asp Gly Trp 65 70 75 80 Cys Leu Glu Ala Phe Ser Tyr Ala Gln
Gly Arg Cys Leu Ser Asp Leu 85 90 95 Asn Ser Ala Leu Ile Met Val
Val Val Gly Ser Leu Ser Gln Tyr Gln 100 105 110 Leu Met Lys His Gln
Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr 115 120 125
Leu Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys 130
135 140 Ser Gln Gln Ile Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn
Ile 145 150 155 160 <210> SEQ ID NO 89 <211> LENGTH:
150 <212> TYPE: PRT <213> ORGANISM: Drosophila
melanogaster <400> SEQUENCE: 89 Asp Ala Gly Lys Leu Tyr Asp
Ala Ile Ile Leu His Ser Glu Lys Asp 1 5 10 15 Tyr Glu Phe Val Cys
Arg Asn Ile Ala Ala Glu Leu Glu His Gly Arg 20 25 30 Pro Pro Phe
Arg Leu Cys Ile Gln Gln Arg Asp Leu Pro Pro Ala Ser 35 40 45 His
Leu Gln Leu Val Glu Gly Ala Arg Ala Ser Arg Lys Ile Ile Leu 50 55
60 Val Leu Thr Arg Asn Leu Leu Ala Thr Glu Trp Asn Arg Ile Glu Phe
65 70 75 80 Arg Asn Ala Phe His Glu Ser Leu Arg Gly Leu Ala Lys Leu
Val Ile 85 90 95 Ile Glu Glu Thr Ser Val Ser Ala Glu Ala Glu Asp
Val Ala Glu Leu 100 105 110 Ser Pro Tyr Leu Lys Ser Val Pro Ser Asn
Arg Leu Leu Thr Cys Asp 115 120 125 Arg Tyr Phe Trp Glu Lys Leu Arg
Tyr Ala Ile Pro Ile Glu Leu Ser 130 135 140 Pro Arg Gly Asn Asn Tyr
145 150 <210> SEQ ID NO 90 <211> LENGTH: 144
<212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster
<400> SEQUENCE: 90 Asp Lys Asp Lys Arg Phe Asp Ala Phe Leu
Ala Phe Thr His Lys Asp 1 5 10 15 Glu Ala Leu Leu Glu Glu Phe Val
Asp Arg Leu Glu Arg Gly Arg Pro 20 25 30 Arg Phe Gln Leu Cys Phe
Tyr Leu Arg Asp Trp Leu Ala Gly Glu Ser 35 40 45 Ile Pro Asp Cys
Ile Gly Gln Ser Ile Lys Asp Ser Arg Arg Ile Ile 50 55 60 Val Leu
Met Thr Glu Asn Phe Met Asn Ser Thr Trp Gly Arg Leu Glu 65 70 75 80
Phe Arg Leu Ala Leu His Ala Thr Ser Arg Asp Arg Cys Arg Leu Ile 85
90 95 Val Val Leu Tyr Pro Asn Val Lys Asn Phe Asp Ser Leu Asp Ser
Glu 100 105 110 Leu Arg Thr Tyr Met Ala Phe Asn Thr Tyr Leu Glu Arg
Ser His Pro 115 120 125 Asn Phe Trp Asn Lys Leu Ile Tyr Ser Met Pro
His Thr Lys Leu Arg 130 135 140 <210> SEQ ID NO 91
<211> LENGTH: 150 <212> TYPE: PRT <213> ORGANISM:
Drosophila melanogaster <400> SEQUENCE: 91 Asp Lys Asp Lys
Lys Phe Asp Ala Phe Ile Ser Tyr Ser His Lys Asp 1 5 10 15 Gln Ser
Phe Ile Glu Asp Tyr Leu Val Pro Gln Leu Glu His Gly Pro 20 25 30
Gln Lys Phe Gln Leu Cys Val His Glu Arg Asp Trp Leu Val Gly Gly 35
40 45 His Ile Pro Glu Asn Ile Met Arg Ser Val Ala Asp Ser Arg Arg
Thr 50 55 60 Ile Ile Val Leu Ser Gln Asn Phe Ile Lys Ser Glu Trp
Ala Arg Leu 65 70 75 80 Glu Phe Arg Ala Ala His Arg Ser Ala Leu Asn
Glu Gly Arg Arg Ile 85 90 95 Ile Val Ile Ile Tyr Ser Asp Ile Gly
Asp Val Glu Lys Leu Asp Glu 100 105 110 Glu Leu Lys Ala Tyr Leu Lys
Met Asn Thr Tyr Leu Lys Trp Gly Asp 115 120 125 Pro Trp Phe Trp Asp
Lys Leu Arg Phe Ala Leu Pro His Arg Arg Pro 130 135 140 Val Gly Asn
Ile Gly Asn 145 150 <210> SEQ ID NO 92 <211> LENGTH:
153 <212> TYPE: PRT <213> ORGANISM: Nicotiana tabacum
<400> SEQUENCE: 92 Ser Ser Arg Trp Ser Tyr Asp Val Phe Leu
Ser Phe Arg Gly Glu Asp 1 5 10 15 Thr Arg Lys Thr Phe Thr Ser His
Leu Tyr Glu Val Leu Asn Asp Lys 20 25 30 Gly Ile Lys Thr Phe Gln
Asp Asp Lys Arg Leu Glu Tyr Gly Ala Thr 35 40 45 Ile Pro Gly Glu
Leu Cys Lys Ala Ile Glu Glu Ser Gln Phe Ala Ile 50 55 60 Val Val
Phe Ser Glu Asn Tyr Ala Thr Ser Arg Trp Cys Leu Asn Glu 65 70 75 80
Leu Val Lys Ile Met Glu Cys Lys Thr Arg Phe Lys Gln Thr Val Ile 85
90 95 Pro Ile Phe Tyr Asp Val Asp Pro Ser His Val Arg Asn Gln Lys
Glu 100 105 110 Ser Phe Ala Lys Ala Phe Glu Glu His Glu Thr Lys Tyr
Lys Asp Asp 115 120 125 Val Glu Gly Ile Gln Arg Trp Arg Ile Ala Leu
Asn Glu Ala Ala Asn 130 135 140 Leu Lys Gly Ser Cys Asp Asn Arg Asp
145 150 <210> SEQ ID NO 93 <211> LENGTH: 151
<212> TYPE: PRT <213> ORGANISM: Linum usitatissimum
<400> SEQUENCE: 93 Phe Pro Ser Val Glu Tyr Glu Val Phe Leu
Ser Phe Arg Gly Pro Asp 1 5 10 15 Thr Arg Glu Gln Phe Thr Asp Phe
Leu Tyr Gln Ser Leu Arg Arg Tyr 20 25 30 Lys Ile His Thr Phe Arg
Asp Asp Asp Glu Leu Leu Lys Gly Lys Glu 35 40 45 Ile Gly Pro Asn
Leu Leu Arg Ala Ile Asp Gln Ser Lys Ile Tyr Val 50 55 60 Pro Ile
Ile Ser Ser Gly Tyr Ala Asp Ser Lys Trp Cys Leu Met Glu 65 70 75 80
Leu Ala Glu Ile Val Arg Arg Gln Glu Glu Asp Pro Arg Ile Ile Leu 85
90 95 Pro Ile Phe Tyr Met Val Asp Pro Ser Asp Val Arg His Gln Thr
Gly 100 105 110 Cys Tyr Lys Lys Ala Phe Arg Lys His Ala Asn Lys Phe
Asp Gly Gln 115 120 125 Thr Ile Gln Asn Trp Lys Asp Ala Leu Lys Lys
Val Gly Asp Leu Lys 130 135 140 Gly Trp His Ile Gly Lys Asn 145 150
<210> SEQ ID NO 94 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic 6xHis tag <400> SEQUENCE: 94 His His His His His
His 1 5
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