U.S. patent application number 12/422806 was filed with the patent office on 2010-10-14 for integrated breast x-ray and molecular imaging system.
Invention is credited to Ken Brooks, Ken F. DeFreitas, Baorui Ren, Ian Shaw, Andrew P. Smith, Jay Stein, Jing Zhenxue.
Application Number | 20100260316 12/422806 |
Document ID | / |
Family ID | 42422154 |
Filed Date | 2010-10-14 |
United States Patent
Application |
20100260316 |
Kind Code |
A1 |
Stein; Jay ; et al. |
October 14, 2010 |
Integrated Breast X-Ray and Molecular Imaging System
Abstract
An integrated tomosynthesis/molecular breast imaging device
having improved sensitivity includes tomosynthesis imaging
components and molecular breast imaging components. The imaging
components may be used individually or in combination to provide a
system with improved sensitivity and specificity. Molecular imaging
components may be smoothly advanced or withdrawn depending upon the
desired imaging mode. The system supports both PET and SPECT
imaging and enables SPECT collimation to be modified in accordance
with image capture requirements.
Inventors: |
Stein; Jay; (Boston, MA)
; Ren; Baorui; (Andover, MA) ; Smith; Andrew
P.; (Lexington, MA) ; Brooks; Ken; (Knoxville,
TN) ; Zhenxue; Jing; (Chadds Ford, PA) ; Shaw;
Ian; (Yorktown Heights, NY) ; DeFreitas; Ken F.;
(Patterson, NY) |
Correspondence
Address: |
CYTYC CORPORATION;Darry Pattinson, Sr. IP Paralegal
250 CAMPUS DRIVE
MARLBOROUGH
MA
01752
US
|
Family ID: |
42422154 |
Appl. No.: |
12/422806 |
Filed: |
April 13, 2009 |
Current U.S.
Class: |
378/37 |
Current CPC
Class: |
A61B 6/4441 20130101;
A61B 6/4021 20130101; A61B 6/5235 20130101; A61B 6/06 20130101;
A61B 6/502 20130101; A61B 6/025 20130101; A61B 6/4291 20130101;
A61B 6/4411 20130101; A61B 6/0414 20130101; A61B 6/037
20130101 |
Class at
Publication: |
378/37 |
International
Class: |
A61B 6/04 20060101
A61B006/04 |
Claims
1. A breast imaging device comprising: tomosynthesis imaging
components for obtaining tomosynthesis images of an anatomical
structure of a breast; and molecular imaging components for
obtaining molecular breast images of a physiological structure of
the breast.
2. The breast imaging device of claim 1 further comprising a
compression assembly mounted on a gantry base and a receptor
housing coupled to the gantry base.
3. The breast imaging system of claim 2 wherein the tomosynthesis
imaging components comprise: an x-ray assembly pivotably mounted on
the gantry base, the x-ray assembly comprising an x-ray source
mounted on an x-support arm; and a digital detector disposed within
the receptor housing.
4. The breast imaging system of claim 3 wherein a target of the
x-ray source is selected from a group including tungsten and
rhodium.
5. The breast imaging system of claim 1 wherein the molecular
imaging components comprise at least one positionable gamma
camera.
6. The breast imaging system of claim 5 wherein a positioning of
the positionable gamma camera is motor controlled.
7. The breast imaging system of claim 5 wherein a positioning of
the positionable gamma camera is manually controlled.
8. The breast imaging system of claim 5 wherein the positionable
gamma camera is at least one of retractable, rotatable and
pivotable.
9. The breast imaging system of claim 5 wherein the molecular
imaging components comprise a first positionable gamma camera
coupled to the gantry base and a second positionable gamma camera
selectively disposed within the receptor housing.
10. The breast imaging system of claim 5 wherein the gamma camera
includes a removable collimator.
11. The breast imaging system of claim 8 wherein the removable
collimator is at least one of retractable from the receptor
housing, removable from the receptor housing or ejectable from the
receptor housing.
12. The breast imaging system of claim 10 wherein movement of the
collimator is motor controlled.
13. The breast imaging system of claim 10 wherein movement of the
collimator is manually controlled.
14. The breast imaging system of claim 1 wherein the molecular
imaging components comprise at least two collimators.
15. The breast imaging system of claim 1 wherein the molecular
imaging components include a collimator with moveable
collimation.
16. The breast imaging system of claim 5 wherein the at least one
positionable gamma camera is a Positron Emission camera.
17. The breast imaging system of claim 5 wherein the at least one
positionable gamma camera is a Single Photon Emission camera.
18. The breast imaging system of claim 1 further comprising a
display for displaying the tomosynthesis images and the molecular
breast images.
19. The breast imaging system of claim 18 wherein the tomosynthesis
images comprise tomosynthesis projection images (Tp) and
tomosynthesis reconstructed (Tr) images, and wherein the molecular
breast images (MBI) comprise at least one of MBI projection images
and MBI reconstructed images, and wherein the display is adapted to
display any two of the Tr, Tp, MBI projection and MBI reconstructed
images in any one of a cine mode, toggle mode, thumbnail mode or
side by side mode.
20. The breast imaging system of claim 1 further comprising
computer aided detection (CAD) tools for identifying potential
lesions in any of the tomosynthesis and molecular breast
images.
21. The breast imaging system of claim 2 wherein the receptor
housing is sized to accommodate a digital detector, a gamma camera
and an anti-scatter grid.
22. The breast imaging system of claim 1 wherein the tomosynthesis
imaging component includes a digital detector, the molecular
imaging components include a gamma detector and wherein the digital
detector and gamma detector differ in size.
23. The breast imaging system of claim 22 wherein the molecular
imaging components include a pair of gamma detectors, and wherein
at least two of the tomosynthesis detector and pair of gamma
detectors differ in size.
24. The breast imaging system of claim 2 wherein the compression
assembly is used for both tomosynthesis imaging and molecular
imaging, and wherein the compression assembly applies a different
amount of compression for tomosynthesis imaging than for molecular
imaging.
25. A method of imaging a breast in an integrated
tomosynthesis/molecular breast imaging (T/MBI) device includes the
steps of: immobilizing the breast; performing a tomosynthesis scan
of the breast; obtaining a molecular image of the breast; and
decompressing the breast.
26. The method of claim 25, further including the step of varying a
compression of the breast between the step of performing the
tomosynthesis scan and the step of obtaining the molecular
image.
27. The method of claim 25 further including the step of removing
molecular imaging components from an xray field of view prior to
performing the tomosynthesis scan of the breast.
28. The method of claim 25 wherein the step of obtaining a
molecular image of the breast includes the step of advancing a
gamma camera proximate to the compressed breast.
29. The method of claim 28 wherein the T/MBI device includes a
gantry comprised of an x-ray assembly, a gantry base and a receptor
housing and wherein the step of advancing a gamma camera proximate
to the compressed breast includes the step of moving a gamma camera
from within the gantry base into the receptor housing.
30. The method of claim 28 wherein the T/MBI device includes a
gantry comprised of an x-ray assembly, a gantry base and a receptor
housing, and wherein a compression assembly including a compression
paddle having a compression well is slideably mounted to the gantry
base, and wherein the step of advancing a gamma camera proximate to
the compressed breast includes the step of moving a gamma camera
from within the gantry base into the compression well of the
compression paddle.
31. A method of obtaining a molecular breast image using a gamma
camera comprising a collimator includes the steps of: immobilizing
a breast; obtaining a first exposure of the breast to identify a
suspect lesion; modifying the collimator of the gamma camera; and
obtaining a second exposure of the breast, wherein the step of
modifying the collimator focuses imaging on the suspect lesion.
32. The method of claim 31 wherein a first duration of the first
exposure is smaller than a second duration of the second
exposure.
33. The method of 31 wherein the step of modifying the collimator
of the gamma camera is motor controlled.
34. A method of obtaining a molecular breast image using a gamma
camera comprising a collimator includes the steps of: immobilizing
a breast; obtaining a first exposure of the breast; modifying a
position of the gamma camera; and obtaining a second exposure of
the breast.
35. The method of claim 34 wherein the step of modifying the
position of the gamma camera directs the gamma camera towards at
least one of the axilla and the chest wall.
36. The method of claim 34 wherein the step of modifying the
position is motor controlled.
37. A method of obtaining three-dimensional image data of a breast
using a Single Photon Emission Tomography (SPECT) gamma camera
includes the step of: immobilizing a breast that has been injected
with a radioisotope; obtaining a plurality of molecular images of
the breast by positioning the SPECT camera at a plurality of
different positions relative to the breast for an exposure period
to obtain a plurality of SPECT projection images; and
reconstructing the projection images into a three-dimensional data
set for display on a display device.
Description
FIELD OF THE INVENTION
[0001] This invention relates generally to the field of breast
imaging and more particularly to a system and process for breast
imaging which integrates multiple imaging modalities such as
tomosynthesis imaging and molecular breast imaging into a single
imaging device.
BACKGROUND OF THE INVENTION
[0002] The quality of a breast cancer imaging technique is
frequently evaluated in terms of its sensitivity and specificity.
Sensitivity is the ability of the imaging technology to detect a
cancerous lesion. Specificity is the ability of the imaging
technology to ignore objects in images which merely appear similar
to lesions. It is thus desirable to use a breast cancer imaging
technology that is both sensitive (to ensure that cancerous lesions
are not missed) and specific (to reduce the number of medical
procedures when no cancer is present).
[0003] Mammography is currently the most frequently utilized FDA
approved method for breast cancer screening. However, mammograms
suffer in both the area of sensitivity and specificity. During a
mammogram, x-rays are directed at compressed breast tissue to
generate one or more images (mammograms) of the breast for review.
However, because mammograms are two dimensional representations of
a three dimensional structure, the sensitivity of a mammogram is
compromised due to overlapping structures in the compressed breast.
In addition, the similarity of x-ray attenuation characteristics
between breast tissue and cancerous tissue increases the difficulty
of differentiating cancerous lesions from breast tissue,
particularly when imaging dense breast tissue.
[0004] Efforts to improve the sensitivity and specificity of breast
x-rays have included the development of breast tomosynthesis
systems. Breast tomosynthesis is a three-dimensional imaging
technology that involves acquiring images of a stationary
compressed breast at multiple angles during a short scan. The
individual images are then reconstructed into a series of thin,
high-resolution slices that can be displayed individually or in a
dynamic cine mode.
[0005] Reconstructed tomosynthesis slices reduce or eliminate the
problems caused by tissue overlap and structure noise in single
slice two-dimensional mammography imaging. Digital breast
tomosynthesis also offers the possibility of reduced breast
compression, improved diagnostic and screening accuracy, fewer
recalls, and 3D lesion localization. Examples of breast
tomosynthesis systems are described in U.S. Pat. Nos. 7,245,694 and
7,123,684, commonly owned by the Assignee of this application.
While breast tomosynthesis methods greatly improve the sensitivity
of x-ray cancer screening, specificity issues associated with dense
breasts remain an issue.
[0006] Perhaps the most sensitive breast imaging modality is
Molecular Resonance Imaging (MRI). However the sensitivity of the
MRI modality negatively affects its specificity. In addition, the
cost of the MRI devices limits their general deployment. Molecular
Breast Imaging (MBI) has advanced considerably in recent years as
more clinical data has become available. The clinical advantages of
MBI include sensitivity similar to that of MRI modalities but with
a much better specificity and at a much lower cost
SUMMARY OF THE INVENTION
[0007] According to one aspect of the invention it is realized that
breast cancer diagnosis may be improved via the introduction of an
integrated multi-modal breast imaging system which combines
tomosynthesis imaging capability with molecular imaging capability
in a single, integrated breast imaging device. Tomosynthesis
capability is provided using breast X-ray components capable of
performing mammography, tomosynthesis and stereotactic imaging for
routing breast cancer screening and diagnosis. The x-ray components
generate two-dimensional and three-dimensional anatomical images
based on the absorption of x-rays by the breast.
[0008] The integrated device also provides molecular imaging
capability via molecular imaging components capable of imaging a
breast using methods such as single photon planar imaging, Positron
Emission Tomography (PET), and Single Photon Emission Computed
Tomography (SPECT). Molecular imaging may be used on its own or in
conjunction with x-ray imaging. Molecular breast imaging generates
a physiological image of the breast based on the absorption and
decay of radioisotopes that have been injected into the breast.
[0009] The present invention fuses tomosynthesis imaging capability
and molecular imaging capabilities into a single breast imaging
device. Integrating the different imaging modalities into a single
imaging device may increase the speed and accuracy of diagnosis by
enabling the radiologist to tune the diagnostic workflow according
to the particular needs of each patient. For example the
radiologist may choose to use one modality over another depending
upon a known anatomical structure (i.e., density) of the patient's
breast. Or the radiologist may use the two diagnostic imaging
methods in sequence to obtain additional information as needed. For
example, if a routine mammogram such as that shown in FIG. 1A,
obtained using the x-ray components, suggests the presence of a
lesion 10, the radiologist may opt to obtain a molecular image of
the patient's breast during the patient's visit. The molecular
image verifies the presence of lesion 10, while also highlighting
additional calcifications 12, 14, which may have been missed in the
x-ray image. The present invention enables tomosynthesis images and
molecular images to be viewed together on a single display, either
side by side (for example providing both FIGS. 1A and 1B on a
display), overlaid, in cine mode, etc. The ability to obtain the
molecular image with the same equipment during a single office
visit facilitates registration of the images, allows comparison of
the anatomical and physiological information of the breast at a
slice granularity, allows comparison of CAD results of the images,
increases the speed and accuracy of the diagnosis and thereby
reduces unnecessary biopsies and concomitant patient anxiety.
[0010] According to one aspect of the invention, a breast imaging
device includes tomosynthesis imaging components for obtaining
tomosynthesis images of an anatomical structure of a breast and
molecular imaging components for obtaining molecular breast images
of a physiological structure of the breast.
[0011] According to a further aspect of the invention, a method of
imaging a breast in an integrated tomosynthesis/molecular breast
imaging (T/MBI) device includes the steps of compressing the
breast, performing a tomosynthesis scan of the breast, obtaining a
molecular image of the breast and decompressing the breast
BRIEF DESCRIPTION OF THE FIGURES
[0012] FIGS. 1A and 1B are respective x-ray and molecular images of
a breast;
[0013] FIG. 2 is an exemplary embodiment of a fused multi-modal
three dimensional breast imaging system of the present
invention;
[0014] FIG. 3 is a block diagram of a cross section of the gantry
base and receptor housing of the device of FIG. 2;
[0015] FIGS. 4A and 4B are diagrams illustrating gamma ray
dispersion from single-photon and positron radioisotopes;
[0016] FIGS. 5A and 5B illustrate various embodiments of gamma
detectors which may be included in the Tomosynthesis/Molecular
Breast Imaging (T/MBI) device of the present invention;
[0017] FIG. 6 illustrates the positioning of gamma cameras and flow
of gamma rays during Positron Emission Tomography (PET)
imaging;
[0018] FIG. 7 illustrates a general structure of a single photon
planar gamma camera that may be integrated into the T/MBI device of
the present invention;
[0019] FIG. 8 illustrates various collimators that may be used with
the gamma camera of the present invention;
[0020] FIG. 9 is a flow diagram of exemplary steps that may be
performed during a combined tomosynthesis/molecular imaging process
of the present invention;
[0021] FIG. 10 illustrates an embodiment of the T/MBI device of the
present invention with gamma cameras retracted to eliminate
interference during tomosynthesis imaging;
[0022] FIG. 11 illustrates an embodiment of the T/MBI device of the
present invention with gamma cameras positioned for molecular
imaging;
[0023] FIG. 12 illustrates the T/MBI device in a radiology
suite;
[0024] FIG. 13 illustrates a dual head molecular breast imaging
system including slanted collimators;
[0025] FIGS. 14A and 14B illustrate alternative collimator
arrangements that may be used for lesion detection;
[0026] FIG. 15 illustrates a dual head molecular breast imaging
arrangement with slanted collimators and its use for mammographic
imaging;
[0027] FIG. 16 is a side view of a dual head MBI system, provided
to illustrate how the dual slanted collimator arrangement improves
visualization of tissue in the chest wall;
[0028] FIGS. 17A and 17B illustrate an alternative collimator
design which may be used to improve sensitivity and tissue coverage
for both the axilla and chest wall during MBI; and
[0029] FIGS. 18A-18B illustrate exemplary embodiments of dual head
molecular breast imaging cameras for needle biopsies;
DETAILED DESCRIPTION
[0030] FIG. 2 illustrates an exemplary embodiment of an integrated
Tomosynthesis/Molecular Breast Imaging (T/MBI) device 100 of the
present invention. The T/MBI device 100 integrates x-ray components
with molecular imaging components to provide a breast imaging
system having increased sensitivity and specificity.
[0031] The T/MBI device 100 of FIG. 2 is shown to include a
generally C shaped gantry comprised of an x-ray tube assembly 108,
a gantry base 106 and a receptor housing 104, each of which is
described in detail below. The C-shaped gantry is slideably mounted
on a stand 140 (FIG. 12) via tracks 101 for movement along a Y axis
to selectively position the gantry for breast imaging.
[0032] X-Ray Tube Assembly 108
[0033] The x-ray tube assembly 108 includes an x-ray tube head 118
and a x-ray support arm 128. The x-ray support arm is pivotably
mounted on the gantry base 106 to enable movement of the x-ray tube
head 118 about a horizontal axis 402 for tomosynthesis imaging. For
example, during an exemplary tomosynthesis image scan, the x-ray
tube head 118 may move from a position of -7.5.degree. to a
position of +7.5.degree.. During the tube movement, a total of 15
exposures are performed, each having duration between 30-60 ms. The
x-ray tube assembly may also obtain mammograms when the x-ray tube
head is positioned at zero degrees.
[0034] X-ray tube head 118 includes an x-ray tube (not shown) for
generating x-ray energy in a selected range, such as 20-50 kV, at
mAs such as in the range 3-400 mAs, with focal spots such as a
nominal size 0.3 mm large spot and nominal size 0.1 mm small spot.
The x-ray tube target may be comprised of tungsten and/or one or
more of technetium, rhodium, ruthenium and palladium. The x-ray
tube may include one or more filters such as molybdenum, rhodium,
aluminum, copper and tin. In addition, the x-ray tube may include
an adjustable collimation assembly selectively for collimating the
x-ray beam from the focal spot in a range such as from 7.times.8 cm
to 24.times.29 when measured at the image plane of an x-ray image
receptor included in the system, at a maximum source-image distance
such as 75 cm. In one exemplary embodiment, the x-ray tube may be
designed with a moving focal spot which counteracts the movement of
the x-ray tube during tomosynthesis imaging to reduce image blur,
such as is described in U.S. Patent application Ser. No.
61/117,453, filed Nov. 28, 2008 and entitled "Method and system for
controlling X-ray Focal spot characteristics for Tomosynthesis and
Mammography Imaging," incorporated herein by reference.
[0035] Gantry base 106 houses motors or other means for controlling
the movement of various components of the T/MBI device 100. For
example, the gantry base houses a motor (X-ray source control 304,
FIG. 3) which controls the movement of the x-ray support arm 128
during tomosynthesis imaging. In addition, the gantry base houses a
motor (Compression assembly control 306, FIG. 3) which controls the
traversal of a compression assembly 110 along the Y-axis as well as
a motor (articulated gamma camera control 302, FIG. 3) that
controls the movement of an articulated gamma camera 20.
[0036] The compression assembly 110 includes a traversing plate
121, a compression arm 132 and a compression paddle 122 which is
releasably coupled to the compression arm 132 via latch 133. In one
embodiment, compression paddles of various sizes can be
interchanged and positioned properly in the field of view of the
image receptor as described in U.S. Pat. No. 7,443,949, entitled
"MAMMOGRAPHY SYSTEM AND METHOD EMPLOYING OFFSET COMPRESSION PADDLES
AUTOMATIC COLLIMATION AND RETRACTABLE ANTI-SCATTER GRID," owned by
the present assignee and incorporated herein by reference. In one
embodiment the compression paddle is molded from a radiolucent
material and comprises a generally rectangular base from which
walls extend to define a compression paddle well 50. The traversing
plate 121 moves up and down along slots 105 in the gantry base to
control the immobilization or compression of a breast placed
between the compression paddle base and a surface 16 of the
receptor housing 104. The force used to immobilize or compress the
breast may vary in response to a number of different factors,
including but not limited to a mode of imaging (x-ray, MBI), a type
of imaging (tomosynthesis, x-ray, stereotactic), an angle of
imaging (CC or MLO), a size or thickness of a breast, a density of
a breast, etc. As the breast is compressed, the compression paddle
122 may be permitted to tilt so that a uniform compression is
provided across the entire breast.
[0037] According to one aspect of the invention, an articulated
gamma camera assembly 20 is also mounted to the traversing plate
121. The articulated gamma camera assembly 20 includes a support
brace 21, a pair of jointed arms 22 and 24, camera mounts 23 and 25
and gamma camera 26. The gamma camera is essentially a photon
detector which counts and images photons emitted from decaying
radioisotopes which have been injected into the breast (either
single or dual photon emitting isotopes as will be described later
herein). The jointed arms 22 and 24 are coupled to the support
brace 21 and camera mounts 23 and 25 by motorized gears which
control the advancement of the gamma camera 26 into an imaging
position (shown in FIGS. 2 and 11) and the retraction of the gamma
camera 26 into a retracted position (shown in FIG. 10). In one
embodiment when the articulated camera is placed in the imaging
position it rests within the compression paddle well 50 such that
an imaging face of the camera 26 remains flush against the
rectangular base of the compression paddle as the paddle compresses
or otherwise immobilizes the breast The jointed arms 23 and 24
enable the camera to remain flush against the paddle even when the
paddle tilts during compression.
[0038] In another embodiment, the gamma camera need not remain
flush in the compression plate well, but rather may be pivoted to
any angle around an axis defined by the camera mounts. The pivoting
may be manually controlled or motorized. The ability of the
articulated gamma camera to pivot freely in this manner allows for
improved imaging of the chest wall or axilla tissue. In still a
further embodiment, the articulated arms of the gamma camera may be
positioned not at the sides of the camera, as shown in FIG. 2, but
closer towards the center of the gamma camera. In a representative
embodiment, the pair of arms may be replaced with a single
articulated arm which is coupled to a mount on the top
(non-imaging) surface of the gamma camera, allowing the camera to
be pivoted in three dimensions.
[0039] As mentioned above, the articulated arms control the
advancement of the camera towards an imaging field, and the
retraction of the camera away from the imaging field. In one
embodiment, the motion of the camera from the retracted to the
position to the advanced position is controlled such that the
leading edge of the camera (i.e., the edge facing the patient)
travels along an underhanded arc path (as indicated by the arrow
1200 in FIG. 10). Introducing the gamma cameras into the imaging
field in this manner keeps the camera below the line of vision of
the patient and may therefore reduce patient anxiety. The camera
may be retracted from the imaging field with a leading edge (the
edge facing away from the patient) travels in a generally
underhanded arcuate path towards the device, also indicated by the
arrow 1200 of FIG. 10. Of course other methods of introducing the
camera into the imaging field, including lowering the camera into
the field on a track or from a pivot point, may be substituted
herein without affecting the scope of the present invention in one
embodiment, the movement of the camera 26 is synchronized with the
movement of gamma camera 115, although this is not a requirement of
the invention and other embodiments wherein the cameras are
independently advanced and retracted are within the scope of the
present invention.
[0040] Receptor Housing 104
[0041] The receptor housing 104 is an enclosed housing for the
detector subsystem of the T/MBI device. As mentioned above, an
upper surface 116 of the housing 104 serves as a breast compression
plate, or bucky. FIG. 2 includes a cut away view of the receptor
housing provided solely for the purpose of describing the internal
detector subsystem 117. The detector subsystem includes at least a
retracting gamma camera 115 and a full field digital detector 114.
The retracting gamma camera 115 is a photon detector which counts
photons emitted from decaying radioisotopes which have been
injected into the breast (either single or dual photon emitting
isotopes). The full field digital detector 114 is an x-ray detector
such as the amorphous selenium digital detectors described in U.S.
Pat. Nos. 7,122,803, 7,233,005 and 7,304,308 owned by the assignee
of the present invention and incorporated herein by reference. It
should be noted that the present invention is not limited to
systems which use amorphous digital detectors, and other detectors
such as scintillating detectors may be substituted herein without
affecting the scope of the invention. In one embodiment, the
digital detector is adapted for movement within the receptor
housing; for example, the digital detector 114 may move laterally
or pivot about one or more points during tomosynthesis imaging.
Such movement of the detector may be controlled by a rotate/retract
control motor 310 (FIG. 3) located within the gantry base 106.
[0042] FIG. 3 is a block diagram of a cross-section of the receptor
housing 104 and a portion of the gantry base 106 illustrating the
detector subsystem in greater detail. As mentioned above, the
gantry base houses several control systems (302-310).
[0043] Although the control systems are represented in the figures
as discrete functional blocks it should be recognized that such
delineations are provided merely to facilitate the description of
the device and not by way of limitation; it is appreciated that
there are numerous different but equivalent ways that the
functionality may be combined and embodied that are within the
scope of the present invention.
[0044] An anti-scatter grid 111 is shown positioned between the
detector 114 and the gamma camera 115. As described in U.S. Pat.
No. 7,443,949, referenced above, the anti-scatter grid is
positioned over the digital detector 114 (in position A) during
mammography, to reduce x-ray scatter. The anti-scatter grid may be
withdrawn for tomosynthesis and/or other x-ray imaging, preferably
via motorized retraction of the anti-scatter grid (to position A')
in the gantry base as indicated by dashed line in FIG. 3.
[0045] According to one aspect of the invention gamma camera 115 is
withdrawn from the x-ray imaging field of view prior to x-ray
imaging. In one embodiment, the gamma camera may be withdrawn by
retracting the camera 115 into the gantry base 106. For example,
gamma camera 115 may be positioned at location G during molecular
imaging, but moved to position G' for x-ray imaging. The retraction
of the gamma camera 115 may be motorized, or alternatively may be
achieved through manual means (i.e., via a manual lever to slide
the camera into the housing). In another embodiment, the gamma
camera may be withdrawn from the x-ray imaging field of view by
removing the camera from the device 100, for example by ejecting
the camera or otherwise extracting the camera from at least part of
the housing 104.
[0046] As will be described in more detail later herein, the gamma
camera may also be rocked or rotated around one or more pivot
points, or moved laterally or vertically for molecular imaging. For
example it may be desirable to rotate the camera towards the
patient to better image the chest wall or axilla tissue. The
receptor housing is therefore of sufficient size to house the gamma
camera 115, anti-scatter grid 111 and digital detector 114 and to
allow movement of both the digital detector as well as the gamma
camera. The movement of the gamma camera may also be controlled by
the rotate/retract controller 310.
[0047] According to one aspect of the invention rotate/redaction
control further includes functionality for motorized retraction of
a collimator 215 of a gamma camera (for example by moving the
collimator from position C to C') or otherwise withdrawing the
collimator from the molecular imaging field. For example, like the
anti-scatter grid, the collimators may be moved into the gantry
base (either by motor or manually) or may be ejectable. In still
another embodiment, the bucky surface 116 may be hinged to permit
manual access to the collimators of the gamma cameras, to allow the
collimators to be swapped, exchanged, flipped or otherwise
modified. The ability to retract or otherwise remove the collimator
in this manner allows a single gamma camera to be used for
molecular imaging using both Single Positron Emission radioisotopes
as well as Positron Emission radioisotopes.
[0048] The functionality may also be adapted provide motorized
exchange a collimator that is disposed over a scintillator/detector
structure 315 of the gamma camera with different collimator
selected from a group of alternative collimators 1215 stored within
the housing. The collimator may be of a different type, or of the
same type but having different angular collimations. The ability to
exchange collimators in this manner allows the radiologist to
customize the camera in accordance with a desired view. In still
another embodiment a programmable collimator capable of selective
modification the collimation angle may be used for custom
imaging.
[0049] In still yet another embodiment, the gamma camera can be
tilted at varying angles during the acquisition. For example, the
gamma camera 26 can be moved away from paddle 122 sufficiently to
allow angulation of the gamma camera and so acquire views of the
breast with different angles and therefore acquire information that
can be used to perform a reconstruction such as SPECT or
tomosynthesis view of the distribution of radiopharmaceuticals. In
this mode, the gamma camera would be placed in a given orientation
relative to the breast, and an image acquired for a time inverval.
The gamma camera would then be positioned in an different
orientation and a second image acquired. Multiple images of the
breast are then acquired and these are used in the
reconstruction.
[0050] X-Ray Imaging
[0051] As mentioned above, the T/MRI device is capable of
performing both X-ray and molecular breast imaging. During x-ray
imaging x-rays emitted from an x-ray source are directed at a body
part to be imaged. The x-rays penetrate the body part and are
attenuated differently depending upon the structures that they
encounter. An x-ray detector on the underside of the body part
records the resultant x-ray energy, providing a pictorial
representation of the x-ray attenuation and associated anatomical
structure of the body part.
[0052] In one embodiment, the x-ray system may be configured for
mammographic imaging at multiple views (cranio-caudal (CC) and
mediolateral oblique (MLO)), tomosynthesis imaging and stereotactic
imaging. During mammogram acquisition, the compression paddle can
shift automatically depending on the view to be acquired. For
example, the paddle can be centered on the x-ray receptor for a CC
view, shifted to one lateral side of the receptor for an MLO view
of one breast and to the other lateral side of the receptor for an
MLO view of the other breast. In one embodiment, the size and shape
of the paddle can be automatically recognized by the system when
mounted so that the shifts can be adjusted to the type of paddle.
The mammographic images (Mp) are captured as two-dimensional images
which may be stored and/or immediately displayed to the
radiologist.
[0053] During tomosynthesis the breast is compressed and a
plurality of tomosynthesis projection images (Tp) are acquired at
respective angles relative to the breast. A variety of systems are
provided in the art for acquiring breast tomosynthesis image data.
The systems may vary in the number of projection images that are
obtained and the angles at which the images are taken, in the path
that the x-ray source takes when obtaining the projection images
(arcuate, linear, sine-wave motion, etc.), in a motion of the
digital detector (i.e., rocking, rotating, linear movement) and in
reconstruction techniques (back-projection, weighted
back-projection, etc). The present invention may incorporate any
such tomosynthesis system. The projection images are reconstructed
into a plurality of tomosynthesis reconstructed images Tr
representative of breast slices that have selective thicknesses.
Any of the Tp, Tr and Mp images may be displayed individually or
simultaneously on a display screen as described in U.S. patent
application Ser. No. 11/827,909 entitled IMAGE HANDLING AND DISPLAY
IN X-RAY MAMMMOGRAPHY AND TOMOSYNTHESIS, incorporated herein by
reference. Simultaneous viewing of the images may be performed in a
variety of ways, including but not limited to overlaying one image
on another, and toggling between individual or overlaid images or
using cine mode, or having one image displayed as an inset in
another images. Additionally, the two images may be blended
together, or a visual slide bar may be provided such that, as the
bar slides over the image, the image morphs from an image taken in
a first modality to an image taken in a second modality, where the
modality may be an x-ray modality (i.e., mammogram or tomosynthesis
image) a PET or SPECT image.
[0054] Molecular Breast Imaging
[0055] Two types of molecular breast imaging include Single Photon
Emission Tomography (SPECT) and Positron Emission Tomography (PET).
In both forms, the body part to be imaged is injected with a
radioisotope/radiopharmaceutical. Cancerous cells tend to absorb
higher amounts of the radioisotope than non-cancerous cells and
therefore the radioisotope collects in areas of cancerous lesions
in the breast. As the radioisotope decays, gamma rays are emitted
from the radioisotope. The gamma rays are recorded by gamma
cameras, which essentially count the photons in the gamma rays.
Those areas of the breast which have absorbed the largest amounts
of radioisotope will emit the largest number of gamma rays and have
the highest photon counts in the resultant image. The quality of
the image is dependent upon both the radioisotope and the gamma
camera.
[0056] One difference between SPECT and PET lies in the
radioisotope that is used for imaging. For example, as shown in
FIG. 4A, single photon gamma emitters used in SPECT emit a single
gamma ray 410 of energy 80-167+ keV emitted from each decay. Single
Photon radioisotopes include, for example, TC-99 mm (found in
Sestamibi), TI-201 (Found in Thallus Chloride), Xe-133 (Gas), I-123
(IMP), Co-57 (physics), etc. Dual photon Positron Emission
Technology (PET) radioisotopes simultaneously emit dual, co-linear
gamma rays 412, 414 of energy 511 keV each. Examples of PET
radioisotopes include the F-18 isotope which can be found in
FDG.
[0057] FIGS. 5A and 5B illustrate two different embodiments of
gamma detector which may be incorporated into the T/MBI device of
the present invention for PET imaging. FIG. 5A illustrates an Anger
type gamma detector 500 comprised of a scintillator layer 510 and a
visible light detector layer 512. Visible light rays 505 are
generated when a gamma ray 501 strikes the scintillator. The
detectors in layer 512 detect the visible light rays, with the
relative signals of the detectors indicating the location of origin
of the gamma ray. Figure 5B illustrates a discrete gamma detector
515 which may be used for PET imaging and includes separate
scintillators 514 for each detector 516. When a gamma ray strikes
the scintillator layer, resulting visible light photons or charges
511 will only impact a single detector.
[0058] Referring now to FIG. 6, during PET imaging two opposed PET
gamma cameras such as camera 600 and 610 record the gamma
emissions. Using information such as the known spacing of the
cameras, the location of the lesions in three dimensional space may
be readily determined and used to reconstruct a three-dimensional
image PET-MBIr. According to one aspect of the invention, this
three-dimensional image may be viewed as two dimensional slabs of
selectable thickness together with x-ray images (Mp, Tp, Tr) on a
display. The PET-MBIr images may be viewed side by side with the
x-ray images, overlaid with one or more of the x-ray images for
toggling between the images of viewing in cine mode, or one of the
PET-MBIr or X-ray images may be inserted in a thumbnail view in the
other image.
[0059] Single photon imaging involves detecting the individual
photons that are emitted during decay by using a gamma camera.
Photons can emerge unscathed, or can scatter. If the photon
scatters, the energy changes. In order to determine where the
photon emerged from and to ensure that scattered energy is not
erroneously recorded, gamma cameras generally include collimators.
FIG. 7 illustrates exemplary gamma camera 700, which may include
one of the gamma detectors of FIG. 5A or 5B (such as detector 500)
and a collimator 710. The collimator essentially filters out
scatter, for example causing contributions of rays b and c (emitted
from lesion 701) to be rejected or ignored. Three dimensional gamma
images, often called Single Photon Emission Computed Tomography
(SPECT) are formed by acquiring multiple images from a gamma
camera, with each image acquired by having the gamma camera
arranged at different angles relative to the object being
imaged.
[0060] Collimators are generally formed as holes lead, foil stamped
lead or tungsten or lead casts. FIG. 7 illustrates a general
parallel hole type collimator although other types of collimators
may be used for different breast imaging needs. For example,
slanted collimators may be used to provide Z position measurement
for either lesion or biopsy needle with radiotracers. FIG. 8
illustrates various types of collimators that may be included as
part of the T/MBI device 100, including a parallel hole collimator
800, a converging collimator 810, a pin hole collimator 820 and a
diverging collimator 830. As mentioned above with regard to FIG. 2,
the collimators may be stored within or near the device 100, and
swapped as needed. More details regarding how different collimators
may be used to provide improved chest wall and axilla tissue
coverage, as well as for three-dimensional lesion localization and
biopsy is described later herein.
[0061] The SPECT camera operates similarly to a two dimensional
digital detector, capturing a two dimensional projection image
SPECT-MBIp of gamma radiation during each exposure period. A
plurality of projection images SPECT-MBIp can be obtained by moving
the SPECT camera to different angular positions relative to the
imaged object and collecting photon information for the exposure
period. In a system such as the T/MBI system which includes
multiple gamma cameras one or both cameras may be moved through
angular ranges to capture different projection images for each
exposure period. A three-dimensional volume may be reconstructed
from the projection images using techniques such as those described
in U.S. Pat. No. 5,359,637 entitled Self-Calibrated Tomosynthetic,
Radiographic Imaging System, Method and Device, by Weber,
incorporated herein by reference, to provide a three-dimensional
reconstructed data set SPECT-MBIr. According to one aspect of the
invention, this three-dimensional data set may be viewed as two
dimensional slabs of selectable thickness together with x-ray
images (Mp, Tp, Tr) on a display. The SPECT-MBIr images and
SPECT-MBIp images may be viewed side by side with the x-ray images,
overlaid with one or more of the x-ray images for toggling between
the images of viewing in cine mode, or one of the SPECT-MBIr or
X-ray images may be inserted in a thumbnail view in the other
image.
[0062] Workflow
[0063] Having described exemplary components of the T/MBI system,
an exemplary workflow 900 that may be performed to capture both
tomosynthesis and molecular images with a single breast compression
will now be described with regard to the flow chart of FIG. 9 and
the images of the device 100 shown in FIGS. 10 and 11. At step 910
a radioisotope is injected into the breast. At some point
thereafter and in accordance with the half life of the isotope, the
breast is ready for imaging. At step 912 the breast is compressed
between the compression paddle and the bucky 116. At step 914 a
tomosynthesis scan is initiated and the x-ray source traverses
along a path from position Ts to Tf as shown in inset 1100. As the
x-ray source traverses along the path a number of x-ray projection
images are obtained. As shown in FIG. 11 during x-ray imaging the
gamma cameras 115 and 26 are withdrawn such that they do not
encroach upon the x-ray field 1000 or block the detector 114. In
some workflows, a CC mammogram view may be obtained following the
tomosynthesis scan. In such instances the anti-scatter grid will
extend over the detector 114 prior to imaging.
[0064] In the process of FIG. 9 a molecular image is obtained
following the tomosynthesis scan without full breast decompression.
At step 916 the compression of the breast may be adjusted for the
molecular scan. It is not a requirement to adjust the breast
compression, and thus the step is shown in dashed lines to indicate
its optional nature. At step 918 the gamma cameras are moved into
position. In one embodiment the gamma camera 26 moves along path
1100 until it rests flush in the compression paddle well as shown
in FIG. 11. Gamma camera 115 is moved out of the gantry base into
position. In certain gamma camera or SPECT embodiments, only one
gamma camera or SPECT camera may be provided for positioning.
Advantageously the movement and positioning of the cameras is
computer controlled. For example in some embodiments the cameras
may differ in size from each other and/or the digital detector. The
cameras may be positioned in response to the detection of
suspicious artifacts identified during the tomosynthesis screen so
that the cameras are centered on any suspicious artifact, or may be
positioned at angles to capture the axilla tissue or better image
the chest wall. The positioning of the gamma cameras may be
automatic, for example in response to CAD screening of the
tomosynthesis data, or may be controlled via user input.
[0065] At step 920 molecular image data is obtained. For
embodiments that use PET cameras the PET image is obtained by
positioning the PET camera pair around the breast for an exposure
period. As described above, to obtain 3-D image data using SPECT
cameras, the camera(s) may be moved to multiple positions for a
defined set of exposure periods. At step 922, when molecular
imaging is complete gamma camera 26 may be retraced along the path
indicated by line 1100 in FIG. 10, and the breast decompressed at
step 924. Assuming that radioisotope was administered to both
breasts, steps 912-924 may be repeated with the alternate
breast.
[0066] One embodiment shows sequential use of the imaging
modalities. This will include the x-ray image acquired before the
nuclear image. It is also possible to reverse the order of the
acquisitions, and perform the nuclear acquisition before the x-ray
image.
[0067] The T/MBI device however is not limited to sequential use of
the imaging modalities. Rather the provision of different imaging
modalities in a single device enables a radiologist to tailor the
workflow based on the particular need of the patient. For example
when dealing with patients with dense breasts which will x-ray with
low sensitivity, the device allows the radiologist to forego an
x-ray in favor of obtaining a molecular image.
[0068] It should further be noted that there is no requirement that
MBI imaging have a fixed exposure period. For example, a workflow
is envisioned by which the entire breast is imaged at low
resolution for a short period to identify areas of high uptake. A
subsequent exposure may be obtained by imaging just the identified
region at higher resolution, using a converging collimator or
pinhole collimator, for example, or by moving the camera in space
to center the camera upon the region of interest.
[0069] FIG. 12 illustrates the use of the T/MBI device in a
radiology suite. The device 100 may be mounted on a stand 140 for
patient height positioning. The device 100 may be coupled to a
workstation 1010, enabling a radiologist to store and review images
on display 1020. As mentioned above the images from the any of the
imaging modalities including x-ray mammogram images, tomosynthesis
images and molecular images may be displayed either individually or
simultaneously as projection images or reconstructed images. The
images may be displayed side by side, or overlaid. Controls at the
workstation will enable the radiologist to toggle between
two-dimensional projection images, the three dimensional
reconstruction or slices from the same or different modality. In
addition the reviewer may access, either at the workstation or via
a separate workstation, Computer Aided Diagnosis tools which
provide visual indicators of regions of interest on the images. In
one embodiment, CAD results that are obtained from one modality may
be overlaid on images from the second modality; for example
mammography CAD results may be overlaid on MBI images or
tomosynthesis slices, tomosynthesis CAD results may be overlaid on
mammography or MBI results or MBI CAD results may be overlaid on
any x-ray images. In still a further embodiment, CAD results are
generated based on input from both imaging modalities.
[0070] Dual Head MBI features
[0071] As mentioned above, the device is not limited to breast
screening or diagnostic use or to use in combination with the x-ray
imaging components. According to one aspect of the invention, it is
realized that improved three-dimensional lesion localization and
biopsy capability can be provided using a dual-head molecular
breast imaging technology that is capable of modifying the
collimation of the gamma rays. The dual-head MBI device may be part
of the integrated T/MBI device 100 (which, as described with
regards to FIG. 3 may change the collimators that are used with the
gamma detector), or may be provided as a discrete dual-head MBI
device.
[0072] For example FIG. 13 illustrates a dual head MBI imager 1300
having an upper gamma camera 1310 and a lower gamma camera 1320,
and obtaining a cranio-caudal (CC) image of the patient's breast.
The upper camera includes a detector 1314 and a collimator 1312,
while the lower camera includes detector 1324 and collimator 1322.
According to one aspect of the invention, the collimators 1312,
1322 are both slanted collimators which are positioned adjacent and
parallel to each other, with the slant of collimator 1312 being a
mirror image of the slant of collimator 1322. The slants assist in
determining the Z location of the lesion 1330 as follows. As the
radioisotope decays, gamma rays will be emitted from lesion 1330.
The rays are detected at the detector in location b of the upper
camera 1310 and at the detector in location a of the lower camera
1320. With a collimator slant angle of known value ".theta.", a
known value "d" of the distance between the cameras (and associated
breast thickness), the lesion location "h" is derived using
equation I below:
h = d 2 + 1 2 * a - b tan .theta. Equation 1 ##EQU00001##
[0073] This equation can be understood conceptually very easily.
The location on the gamma camera a and the angle of the collimator
holes allow one to determine the trajectory line that the photon
travelled along to result in an image at location a. Similarly for
the other gamma camera location b, one can determine the trajectory
line. The intersection of these two lines determines the point in
three-dimensional space where the lesion is located.
[0074] FIGS. 14A and 14B illustrate alternate embodiments of gamma
cameras, wherein the collimators 1412 and 1410 differ in that
collimator 1412 is a slant collimator of angle ".theta." while the
collimator 1422 is a parallel through hole collimator The
collimators of cameras 1450 and 1460 differ in that collimator 1452
is slanted at a different angle than the collimator 1462. In both
instances, the corresponding lesion height can be derived using
equations similar to that of Equation I but taking into account the
relative difference in collimation angles.
[0075] Providing slanted collimators in a dual-head gamma MBI
system can increase the imaging coverage of the system. When
performing conventional x-ray breast mammographic imaging, breast
tissue outside the compression assembly is not visible in the
resulting image. However, using a dual-head gamma camera with
slanted collimators permits active imaging of axilla and chest
tissue.
[0076] For example FIGS. 1 SA and 15B illustrate respective right
and left media-lateral oblique (MLO) breast views using the dual
slanted collimators 1510 and 1520. The slanted collimators provide
extended tissue coverage of breast tissue that is outside the
active compression area of the detector heads. As labeled, region
"a" has the full system sensitivity thereby enabling views of
tissue within the chest wall. Regions "b" and "c" will have
limited, but not zero, sensitivity, allowing partial sensitivity
for tumor detection within the axilla tissue. Region "d" has no
sensitivity for any tumor detection.
[0077] FIG. 16 illustrates a side view of a CC breast compression.
In general a detector edge has a finite thickness that limits the
detection sensitivity of the breast tissue along an edge, referred
to in FIG. 16 as the dead space 1630. The dead space can be as much
as 5 to 7 mm. Any tumor that is within the dead space or further
within the chest wall is not imaged with conventional x-ray imaging
technology. However an gamma camera with a dual-slanged collimator
overcomes the problems associated with detector dead space and even
enables imaging of breast tissue "a" that extends into the chest
wall. As in FIGS. 15A and 155B, use of the dual slanted collimators
allows areas "b" and "c" to be imaged with some level of
sensitivity.
[0078] In order to improve tissue coverage of both axilla and the
chest wall it is desirable to slant the collimator holes both in
the lateral direction from left to right and in the nipple to the
chest wall direction. FIGS. 17A and 17B illustrate respective
examples 1700 and 1750 of such collimators. In FIG. 17A, one
collimator 1700 that is designed to focus on a region of interest
via the focusing corner 1710 is illustrated. FIG. 17B illustrates a
second embodiment of a custom collimator that may be arranged to
focus on a small region of interest with improved detection
sensitivity. Each of the four collimator segments serves to image
the lesion, and the sensitivity, or number of photons imaged in a
given unit of time, is four times that of a single gamma camera
with collimator pointing at the lesion.
[0079] To perform biopsies the dual-head MBI system the design
should allow simultaneous, active tracing of needle location and
easy access to the breast lesion. FIGS. 18A-18D illustrate various
embodiments of a dual-head MBI system for needle biopsies. In FIG.
18A the cameras 1810 and 1820 are of similar size. Once the lesion
is located, the needle 1830 (coated with tracer material) may be
inserted into the breast. The slant collimators of camera 1810, in
conjunction with data received from camera 1830, enables active
tracing of the needle during the biopsy with real-time needle
trajectory feedback. FIG. 18B illustrates an alternate embodiment,
wherein once the lesion location is identified camera 1810 is
replaced with a smaller camera assembly 1840, which is positioned
such that the edge of camera 1840 clears the known location of the
lesion to allow the biopsy needle to be directed at the lesion.
[0080] In the embodiment illustrated in FIGS. 18C and 18D, the top
camera 1870 is comprised of two smaller detector/collimator
assemblies 1870A and 1870B in close packaging to serve as a larger
size imager. FIG. 18C illustrates the cameras 1870 and 1820 in an
imaging position which is used for lesion localization. In one
embodiment, once the lesion is detected and the location
identified, one half of the assembly (1870B) may be removed to
provide an arrangement such as that shown in FIG. 18B. According to
another embodiment, once the lesion location is detected, the
collimator from one half of the assembly (i.e., the collimator 1875
from portion 1870B) may be removed and flipped to provide a
focusing collimator arrangement such as shown in FIG. 18D.
[0081] Thus it can be seen that the use of one or more slant
collimators can greatly improve viewing coverage of a dual-head
gamma camera breast imaging system, providing improved
three-dimensional localization and biopsy capability as well as
improved coverage of axilla and chest wall tissue. The dual-head
gamma camera breast imaging capability may be provided in a
dedicated system, or alternatively as part of the T/MBI imaging
system described above with regard to FIGS. 1-13.
[0082] The above description thus details the use of a combination
x-ray and gamma camera system for use in cancer screening,
diagnosis and biopsy. It should further be appreciated that the
system may be used to provide three dimensional coordinates of
markers, for example such as the TriMark.TM. Marker provided by
Suros System, Inc., a subsidiary of Hologic, Inc. In addition, the
system may be used to dynamically track a radioactive needle during
a biopsy, for example to perform image guided surgery.
[0083] Accordingly an integrated multi-modal breast imaging system
and method of use has been shown and described. The system combines
tomosynthesis imaging capability with molecular imaging capability
in a single, integrated breast imaging device, resulting in a
breast imaging system with increased sensitivity and sensitivity.
Having described exemplary embodiments of the system, it should
appreciated that the above specific examples and embodiments are
illustrative, and many variations can be introduced on these
examples and embodiments without departing from the spirit of the
disclosure or from the scope of the appended claims. For example,
elements and/or features of different illustrative embodiments may
be combined with each other and/or substituted for each other
within the scope of this disclosure and appended claims.
* * * * *