U.S. patent application number 12/789561 was filed with the patent office on 2010-09-23 for antibodies that specifically bind to reg iv. This patent application is currently assigned to HUMAN GENOME SCIENCES, INC.. Invention is credited to CRAIG A. ROSEN.
Application Number | 20100240875 12/789561 |
Document ID | / |
Family ID | 30000862 |
Filed Date | 2010-09-23 |
United States Patent Application | 20100240875 |
Kind Code | A1 |
ROSEN; CRAIG A. | September 23, 2010 |
The present invention relates to antibodies and related molecules that specifically bind to Reg IV. Such antibodies have uses, for example, in the prevention and treatment of gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes. The invention also relates to nucleic acid molecules encoding anti-Reg IV antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to Reg IV.
Inventors: | ROSEN; CRAIG A.; (LAYTONSVILLE, MD) |
Correspondence Address: |
HUMAN GENOME SCIENCES INC.;INTELLECTUAL PROPERTY DEPT. 14200 SHADY GROVE ROAD ROCKVILLE MD 20850 US |
Assignee: | HUMAN GENOME SCIENCES, INC. ROCKVILLE MD |
Family ID: | 30000862 |
Appl. No.: | 12/789561 |
Filed: | May 28, 2010 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
11583101 | Oct 19, 2006 | 7763244 | ||
12789561 | ||||
11017030 | Dec 21, 2004 | |||
11583101 | ||||
PCT/US03/19908 | Jun 26, 2003 | |||
11017030 | ||||
60392382 | Jul 1, 2002 | |||
Current U.S. Class: | 530/387.3 ; 530/387.9; 530/391.3 |
Current CPC Class: | C07K 2317/21 20130101; C07K 16/18 20130101; C07K 2317/622 20130101; A61K 2039/505 20130101 |
Class at Publication: | 530/387.3 ; 530/387.9; 530/391.3 |
International Class: | C07K 16/28 20060101 C07K016/28 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 176 <210> SEQ ID NO 1 <211> LENGTH: 254
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGB0101 <400> SEQUENCE: 1 Glu Val Gln Leu Val Glu Thr Gly Gly
Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Gln Arg Leu Ser Cys Ala
Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Ala Met His Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile
Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70
75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Lys Gly Ile Arg Tyr Tyr Tyr Asp Ser Ser Gly Tyr
Tyr Asp Gly 100 105 110 Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln
Gly Thr Thr Val Thr 115 120 125 Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly 130 135 140 Gly Ser Ser Glu Leu Thr Gln
Asp Pro Ala Val Ser Val Ala Leu Gly 145 150 155 160 Gln Thr Val Arg
Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr 165 170 175 Thr Asn
Trp Phe Gln Gln Arg Pro Gly Gln Ala Pro Leu Leu Val Val 180 185 190
Tyr Ala Lys Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 195
200 205 Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln
Ala 210 215 220 Glu Asp Glu Ala Asp Tyr Tyr Cys His Ser Arg Asp Ser
Ser Gly Asn 225 230 235 240 His Val Leu Phe Gly Gly Gly Thr Lys Leu
Thr Val Leu Gly 245 250 <210> SEQ ID NO 2 <211> LENGTH:
251 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGB0102 <400> SEQUENCE: 2 Gln Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys
Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile His Trp Val
Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile
Asn Pro Lys Ser Gly Asp Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln
Gly Arg Val Thr Met Ala Arg Asp Thr Ser Met Ser Thr Ala Ser 65 70
75 80 Val Glu Leu Arg Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Arg Asn Ser Phe Asp Phe Gly Ser Gly Tyr Gly Leu
Phe Tyr Gln 100 105 110 Tyr Ile Met Asp Val Trp Gly Gln Gly Thr Leu
Val Thr Val Ser Ser 115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Asp 130 135 140 Ile Gln Met Thr Gln Ser Pro
Ser Phe Leu Ser Ala Ser Val Gly Asp 145 150 155 160 Arg Val Thr Ile
Thr Cys Arg Ala Ser Gln Gly Ile Asn Asn Tyr Leu 165 170 175 Ala Trp
Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr 180 185 190
Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 195
200 205 Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
Glu 210 215 220 Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Asp Tyr
Pro Leu Thr 225 230 235 240 Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Arg 245 250 <210> SEQ ID NO 3 <211> LENGTH: 255
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGB0103 <400> SEQUENCE: 3 Glu Val Gln Leu Leu Glu Ser Gly Gly
Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile
Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70
75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Arg His Tyr Gln Ser Gly Gly Tyr Val Tyr Ile Thr
Phe Tyr Tyr 100 105 110 Pro Met Asp Val Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Ala Leu 130 135 140 Asn Phe Met Leu Thr Gln Pro
His Ser Val Ser Glu Ser Pro Gly Lys 145 150 155 160 Thr Val Thr Leu
Ser Cys Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp 165 170 175 Tyr Val
Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu Val 180 185 190
Ile Phe Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 195
200 205 Gly Ser Ile Asp Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser
Gly 210 215 220 Leu Gln Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Thr
Tyr Asp Asp 225 230 235 240 Asn Arg Gln Val Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu Gly 245 250 255 <210> SEQ ID NO 4 <211>
LENGTH: 248 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGB0104 <400> SEQUENCE: 4 Glu Val Gln Leu Leu Glu Ser
Gly Gly Asp Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser
Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55
60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Glu Asp Arg Met Arg Thr Gln Leu Asp Ser
Trp Gly Arg Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala Gln
Ser Val Leu Thr Gln Pro Pro Ser 130 135 140 Val Ser Gly Ala Pro Gly
Gln Arg Val Thr Ile Ser Cys Thr Gly Ser 145 150 155 160 Ser Ser Asn
Ile Gly Ala Asp Tyr Asp Val His Trp Tyr Gln His His 165 170 175 Pro
Gly Thr Ala Pro Arg Leu Leu Ile Tyr Asp Asn Thr Asn Arg Pro 180 185
190 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala
195 200 205 Ser Leu Thr Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp
Tyr Tyr 210 215 220 Cys Gln Ser Tyr Asp Ala Ser Leu Ser Gly Tyr Val
Val Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 5 <211> LENGTH: 248 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGB0106 <400>
SEQUENCE: 5 Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro
Gly Ser 1 5 10 15 Ser Val Arg Val Ser Cys Lys Val Ser Gly Asp Thr
Ser Thr Ser Tyr 20 25 30 Ile Ile Asn Trp Val Arg Gln Ala Pro Gly
Gln Gly Leu Glu Trp Met 35 40 45 Gly Val Ile Ile Pro Met Phe Gly
Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Glu Asp Arg Val Thr Ile
Ser Ala Asp Gly Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser
Gly Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gly
Ser Asp Phe Trp Ser Gly Tyr Asp Gly Glu Pro Asp Val Phe 100 105 110
Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 115
120 125 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu
Thr 130 135 140 Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val
Arg Ile Thr 145 150 155 160 Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr
Thr Asn Trp Phe Gln Gln 165 170 175 Lys Pro Gly Gln Ala Pro Leu Leu
Val Val Tyr Ala Lys Asn Lys Arg 180 185 190 Pro Ser Gly Ile Pro Asp
Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 195 200 205 Ala Ser Leu Thr
Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr 210 215 220 Tyr Cys
His Ser Arg Asp Ser Ser Gly Asn His Val Leu Phe Gly Gly 225 230 235
240 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 6
<211> LENGTH: 243 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGB0110 <400> SEQUENCE: 6 Glu Val
Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20
25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala
Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Ser Thr Tyr Tyr
Asp Phe Trp Phe Asp Ile Trp Gly Gln 100 105 110 Gly Thr Met Val Thr
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly
Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 130 135 140 Phe
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 145 150
155 160 Ser Gln Gly Ile Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly 165 170 175 Arg Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu
Gln Ser Gly 180 185 190 Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu 195 200 205 Thr Ile Ser Ser Leu Gln Pro Glu Asp
Phe Ala Thr Tyr Tyr Cys Leu 210 215 220 Gln Asp Ser Asp Tyr Pro Leu
Thr Phe Gly Gly Gly Thr Lys Leu Glu 225 230 235 240 Ile Lys Arg
<210> SEQ ID NO 7 <211> LENGTH: 248 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGB0113 <400>
SEQUENCE: 7 Gly Val Gln Leu Val Gln Ser Gly Ala Glu Gly Lys Lys Pro
Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Asn
Ile Ser Arg Phe 20 25 30 Gly Ile Asn Trp Val Arg Gln Ala Pro Gly
Gln Gly Leu Glu Trp Met 35 40 45 Gly Val Ile Ile Pro Met Phe Gly
Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Glu Asp Arg Val Thr Ile
Ser Ala Asp Gly Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser
Gly Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gly
Ser Asp Phe Trp Ser Gly Tyr Asp Gly Glu Pro Asp Val Phe 100 105 110
Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 115
120 125 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu
Thr 130 135 140 Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val
Arg Ile Thr 145 150 155 160 Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr
Thr Asn Trp Phe Gln Gln 165 170 175 Lys Pro Gly Gln Ala Pro Leu Leu
Val Val Tyr Ala Lys Asn Lys Arg 180 185 190 Pro Ser Glu Ile Pro Asp
Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 195 200 205 Ala Ser Leu Thr
Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr 210 215 220 Tyr Cys
His Ser Arg Asp Ser Ser Gly Asn His Val Leu Phe Gly Gly 225 230 235
240 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 8
<400> SEQUENCE: 8 000 <210> SEQ ID NO 9 <211>
LENGTH: 249 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGB0115 <400> SEQUENCE: 9 Gln Leu Gln Leu Gln Glu Ser
Gly Pro Gly Leu Val Lys Pro Ser Gly 1 5 10 15 Thr Leu Ser Leu Asn
Cys Ala Val Ser Gly Asp Ser Ile Ser Ser Gly 20 25 30 Asn Trp Trp
Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Thr
Gly Glu Ile Tyr His Ser Gly Thr Ala Asn Tyr Asn Pro Ser Leu 50 55
60 Lys Ser Arg Val Thr Val Ser Val Asp Lys Ser Thr Asn Gln Phe Ser
65 70 75 80 Leu Arg Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Ala Gly Tyr Tyr Asp Val Gly Leu Pro Phe
Asp Tyr Trp Gly 100 105 110 Lys Gly Thr Leu Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser
Ala Gln Ala Val Leu Thr Gln Pro 130 135 140 Ser Ser Val Ser Gly Ala
Pro Gly Gln Arg Val Thr Leu Ser Cys Thr 145 150 155 160 Gly Ser Ser
Ser Asn Ile Gly Ala Gly Ser Glu Phe His Trp Tyr Gln 165 170 175 Gln
Val Pro Gly Thr Ala Pro Lys Leu Leu Ile Phe Gly Asn Thr Asn 180 185
190 Arg Pro Trp Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr
195 200 205 Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu
Ala Asp 210 215 220 Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Ala
Tyr Val Phe Gly 225 230 235 240 Thr Gly Thr Lys Val Thr Val Leu Gly
245 <210> SEQ ID NO 10 <211> LENGTH: 247 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGB0118
<400> SEQUENCE: 10 Glu Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Met His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn
Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 85
90 95 Ala Arg Asp Leu Leu Ser Tyr Phe Tyr Asp Ser Ser Gly Tyr Leu
Asp 100 105 110 Asn Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ser Glu Leu Thr Gln 130 135 140 Asp Thr Ala Val Ser Val Ala Leu Gly
Gln Thr Val Arg Ile Thr Cys 145 150 155 160 Gln Gly Asp Ser Leu Arg
Ser Tyr Tyr Thr Asn Trp Phe Gln Gln Lys 165 170 175 Pro Gly Gln Ala
Pro Leu Leu Val Val Tyr Ala Lys Asn Lys Arg Pro 180 185 190 Ser Gly
Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala 195 200 205
Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 210
215 220 Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly
Gly 225 230 235 240 Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ
ID NO 11 <211> LENGTH: 248 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGB0128 <400> SEQUENCE: 11
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asp Pro
Trp Ser Asp Ala Phe Asp Leu Trp Gly Arg Gly 100 105 110 Thr Leu Val
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser
Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 130 135
140 Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly
145 150 155 160 Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr
Gln Gln Arg 165 170 175 Pro Gly Ser Ala Pro Ala Thr Val Ile Tyr Glu
Asp Asn Gln Arg Pro 180 185 190 Ser Gly Val Pro Asp Arg Phe Ser Gly
Ser Ile Asp Ser Ser Ser Asn 195 200 205 Ser Ala Ser Leu Thr Ile Ser
Asp Leu Lys Thr Glu Asp Glu Ala Asp 210 215 220 Tyr Tyr Cys Gln Ser
Phe Asp Asn Ser Lys Tyr Val Val Phe Gly Gly 225 230 235 240 Gly Thr
Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 12 <211>
LENGTH: 252 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGB0129 <400> SEQUENCE: 12 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Asp Cys Thr Asn Gly Val Cys
Tyr Leu Pro Phe Asp 100 105 110 Tyr Trp Gly Arg Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ala Leu Asn Phe Met 130 135 140 Leu Thr Gln Pro His
Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr 145 150 155 160 Leu Ser
Cys Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp Tyr Val Gln 165 170 175
Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu Val Ile Phe Glu 180
185 190 Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser
Ile 195 200 205 Asp Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
Leu Gln Ser 210 215 220 Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr
Asp Asp Asn Arg Gln 225 230 235 240 Val Phe Gly Gly Gly Thr Lys Leu
Thr Val Leu Gly 245 250 <210> SEQ ID NO 13 <211>
LENGTH: 246 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGB0137 <400> SEQUENCE: 13 Glu Val Gln Leu Val Gln
Ser Gly Ala Glu Val Glu Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val
Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Gly Asp 20 25 30 Tyr Met
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45
Gly Arg Ile Asp Pro Lys Tyr Gly Asp Thr Asn Tyr Ala Gln Lys Phe 50
55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val
Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Leu
Tyr Phe Cys 85 90 95 Ala Thr Asp Asn Ser Gly Leu Tyr Asp Ala Phe
Asp Lys Trp Gly Lys 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser
Gln Ser Val Leu Thr Gln Pro Ala Ser 130 135 140 Val Ser Gly Ser Pro
Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr 145 150 155 160 Ser Ser
Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His 165 170 175
Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Gly Ser Lys Arg Pro 180
185 190 Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr
Ala 195 200 205 Ser Leu Thr Ile Ser Arg Leu Gln Ala Glu Asp Glu Ala
Asp Tyr Tyr 210 215 220 Cys Ser Ser Tyr Thr Thr Arg Ser Thr Arg Val
Phe Gly Gly Gly Thr 225 230 235 240 Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 14 <211> LENGTH: 249 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGB0146 <400>
SEQUENCE: 14 Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Lys
Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly
Ser Ile Ser Arg Gly 20 25 30 Gly Tyr Tyr Trp Ser Trp Ile Arg Gln
Leu Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr His
Ser Gly Ser Thr Tyr Tyr Asn Pro Pro 50 55 60 Leu Lys Ser Arg Val
Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys
Ala Arg Glu Lys Gly Gly Asp Trp Glu Gln Leu Val Phe Asp His 100 105
110 Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu
Thr Gln 130 135 140 Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val
Thr Ile Ser Cys 145 150 155 160 Ser Gly Ser Thr Ser Asn Ile Gly Asn
Asn Tyr Val Ser Trp Tyr Gln 165 170 175 Gln His Pro Gly Lys Ala Pro
Lys Leu Met Ile Tyr Asp Val Ser Lys 180 185 190 Arg Pro Ser Gly Val
Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn 195 200 205 Ser Ala Ser
Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 210 215 220 Tyr
Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe Leu Phe Gly 225 230
235 240 Thr Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID
NO 15 <211> LENGTH: 249 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGB0153 <400> SEQUENCE: 15
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Ala Gly
Ala Thr Pro Phe Asn Ala Phe Asp Ile Trp Gly 100 105 110 Arg Gly Thr
Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly
Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln 130 135
140 Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Leu Ser Cys
145 150 155 160 Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp Tyr Val Gln
Trp Tyr Gln 165 170 175 Gln Arg Pro Gly Ser Ser Pro Ile Leu Val Ile
Phe Glu Asp Asp Gln 180 185 190 Arg Pro Ser Gly Val Pro Asp Arg Phe
Ser Gly Ser Ile Asp Ser Thr 195 200 205 Ser Asn Ser Ala Ser Leu Thr
Ile Ser Gly Leu Gln Ser Glu Asp Glu 210 215 220 Gly Asp Tyr Tyr Cys
Gln Thr Tyr Asp Asp Asn Arg Gln Val Phe Gly 225 230 235 240 Gly Gly
Thr Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO 16
<211> LENGTH: 247 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGB0163 <400> SEQUENCE: 16 Glu Val
Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20
25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Pro Tyr Tyr Asp
Ser Ser Gly Tyr Tyr Pro Phe Ser Tyr 100 105 110 Trp Gly Arg Gly Thr
Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr 130 135 140 Gln
Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Thr Ile Thr 145 150
155 160 Cys Gly Gly Asp Phe Ala Thr Lys Asn Val Asn Trp Tyr Gln Arg
Lys 165 170 175 Pro Gly Gln Ala Pro Val Thr Val Ile Tyr Tyr Asp Thr
Glu Arg Pro 180 185 190 Ser Ala Ile Pro Glu Arg Phe Ser Gly Ser Asn
Thr Gly Ser Thr Ala 195 200 205 Thr Leu Thr Ile Ser Arg Val Glu Ala
Gly Asp Glu Ala Asp Tyr Tyr 210 215 220 Cys Gln Val Trp Asp Ser Phe
Thr Asp His Arg Leu Phe Gly Gly Gly 225 230 235 240 Thr Lys Leu Thr
Val Leu Gly 245 <210> SEQ ID NO 17 <211> LENGTH: 253
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGB0165 <400> SEQUENCE: 17 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Gly Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Thr Gly Gly Ser Gly Ser Pro Val Tyr Tyr Tyr
Tyr His Tyr Leu 100 105 110 Asp Val Trp Gly Arg Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ala Leu Asn Phe 130 135 140 Met Leu Thr Gln Pro His
Ser Val Ser Glu Ser Pro Gly Lys Thr Val 145 150 155 160 Thr Leu Ser
Cys Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp Tyr Val 165 170 175 Gln
Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu Val Ile Phe 180 185
190 Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser
195 200 205 Ile Asp Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
Leu Gln 210 215 220 Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr
Asp Asp Asn Arg 225 230 235 240 Gln Val Phe Gly Gly Gly Thr Lys Leu
Thr Val Leu Gly 245 250 <210> SEQ ID NO 18 <211>
LENGTH: 248 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGB0174 <400> SEQUENCE: 18 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Ser Asp Ser Asp Ser Ser Asp Tyr Tyr Tyr
Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly
Ser Ala Gln Ser Val Leu Thr Gln Pro 130 135 140 Pro Ser Ala Ser Gly
Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 145 150 155 160 Gly Ser
Ser Ser Asn Ile Gly Phe Asn Asp Val Tyr Trp Tyr Gln Gln 165 170 175
Leu Pro Gly Leu Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg 180
185 190 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Glu Ser Gly Thr
Ser 195 200 205 Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu
Ala Asp Tyr 210 215 220 Tyr Cys Ala Thr Trp Asp Asp Ser Leu Ser Ala
Pro Val Phe Gly Gly 225 230 235 240 Gly Thr Lys Val Thr Val Leu Gly
245 <210> SEQ ID NO 19 <211> LENGTH: 251 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGB0185
<400> SEQUENCE: 19 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn
Pro Lys Ser Gly Asp Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly
Arg Val Thr Met Ala Arg Asp Thr Ser Met Ser Thr Ala Ser 65 70 75 80
Val Glu Leu Arg Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asn Ser Phe Asp Phe Gly Ser Gly Tyr Gly Leu Phe Tyr
Gln 100 105 110 Tyr Ile Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser 115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Asp 130 135 140 Ile Gln Met Thr Gln Ser Pro Ser Phe
Leu Ser Ala Ser Val Gly Asp 145 150 155 160 Arg Val Thr Ile Thr Cys
Arg Ala Ser Gln Gly Ile Asn Asn Tyr Leu 165 170 175 Ala Trp Tyr Gln
Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr 180 185 190 Ala Ala
Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 195 200 205
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 210
215 220 Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Asp Tyr Pro Leu
Thr 225 230 235 240 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245
250 <210> SEQ ID NO 20 <211> LENGTH: 253 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGB0187
<400> SEQUENCE: 20 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asp Ser Cys Pro Tyr Cys Ser Thr Asn Ser Gly Ser Phe
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Leu Asn Phe Met 130 135 140 Leu Thr Gln Pro His Ser Val Ser Glu
Ser Pro Gly Lys Thr Val Thr 145 150 155 160 Ile Ser Cys Thr Arg Thr
Ser Gly Asn Ile Ala Gly Tyr Phe Val Gln 165 170 175 Trp Tyr Gln Gln
Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu 180 185 190 Asp Tyr
Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile 195 200 205
Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Pro 210
215 220 Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asp Thr Ser
Gln 225 230 235 240 Gly Val Phe Gly Ala Gly Thr Lys Leu Thr Val Leu
Gly 245 250 <210> SEQ ID NO 21 <211> LENGTH: 248
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGB0194 <400> SEQUENCE: 21 Glu Val Gln Leu Val Glu Ser Gly
Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Gly Thr Leu Ser Arg Phe 20 25 30 Gly Ile Asn Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Val
Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60
Glu Asp Arg Val Thr Ile Ser Ala Asp Gly Ser Thr Ser Thr Val Tyr 65
70 75 80 Met Glu Leu Ser Gly Leu Lys Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Gly Ser Asp Phe Trp Ser Gly Tyr Asp Gly Glu
Pro Asp Val Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser Glu Leu Thr 130 135 140 Gln Asp Pro Ala Ala Ser
Val Ala Leu Gly Gln Thr Val Arg Ile Thr 145 150 155 160 Cys Gln Gly
Asp Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gln Gln 165 170 175 Lys
Pro Gly Gln Ala Pro Leu Leu Val Val Tyr Ala Lys Asn Lys Arg 180 185
190 Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr
195 200 205 Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala
Asp Tyr 210 215 220 Tyr Cys His Ser Arg Asp Ser Ser Gly Asn His Val
Leu Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 22 <211> LENGTH: 250 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0102 <400>
SEQUENCE: 22 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys
Pro Ser Gly 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly
Ser Ile Ser Ser Ser 20 25 30 Asn Tyr Trp Ser Trp Val Arg Gln Pro
Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Glu Ile Tyr His Asp
Gly Ser Thr Asn Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Val Thr
Met Ser Ala Asp Lys Ser Lys Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu
Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Asp Ser Pro Ser Tyr Ser Ser Gly Trp Tyr Ser Asp Tyr Trp 100 105
110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu
Thr Gln 130 135 140 Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val
Thr Ile Ser Cys 145 150 155 160 Ser Gly Ser Ser Ser Asn Ile Gly Ser
Asn Thr Val Asn Trp Tyr Gln 165 170 175 Gln Leu Pro Gly Thr Ala Pro
Lys Leu Leu Ile Phe Ser Asn Asn Gln 180 185 190 Arg Pro Ser Gly Val
Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 195 200 205 Ser Ala Ser
Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Val 210 215 220 Tyr
Tyr Cys Ala Ala Trp Asp Asp Ser Leu Thr Gly Phe Tyr Val Phe 225 230
235 240 Gly Ala Gly Thr Lys Val Thr Val Leu Gly 245 250 <210>
SEQ ID NO 23 <211> LENGTH: 242 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0104 <400>
SEQUENCE: 23 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys
Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Thr Thr Ser Glu Asn
Thr Phe Arg Arg Ser 20 25 30 Ser Phe Ser Trp Leu Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Ile
His Ser Glu Thr Tyr Ala Gln Asn Phe 50 55 60 Gln Gly Arg Val Thr
Met Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 65 70 75 80 Val Glu Val
Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Asp Ser Pro Pro Tyr Asn Ala Asp Phe Asp Phe Trp Gly Arg 100 105
110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln
Pro Pro 130 135 140 Ser Val Ser Val Ser Pro Gly Gln Thr Ala Thr Ile
Thr Cys Ser Gly 145 150 155 160 Asp Lys Leu Gly Asp Lys Tyr Ala Ser
Trp Tyr Gln Lys Lys Ala Gly 165 170 175 Gln Ser Pro Val Leu Val Ile
Tyr Gln Asp Asn Lys Arg Pro Ser Gly 180 185 190 Ile Pro Glu Arg Phe
Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu 195 200 205 Thr Ile Ser
Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln 210 215 220 Ala
Trp Asp Ser Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val 225 230
235 240 Leu Gly <210> SEQ ID NO 24 <211> LENGTH: 246
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0107 <400> SEQUENCE: 24 Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys
Thr Val Ser Gly Asp Ser Leu Ser Arg Ser 20 25 30 Ser Tyr Tyr Trp
Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile
Gly Ser Val Phe Tyr Ser Gly Ser Ala Asp Tyr Asn Pro Ser 50 55 60
Leu Lys Ser Arg Ala Ser Ile Ser Val Asp Thr Tyr Gln Asn Gln Val 65
70 75 80 Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val
Tyr Tyr 85 90 95 Cys Ala Arg Asp Asp Gly Ser Thr Phe Asp Pro Trp
Gly Arg Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Ala Leu Ser
Tyr Val Leu Thr Gln Pro Pro Ser 130 135 140 Ala Ser Glu Thr Pro Gly
Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 145 150 155 160 Ser Ala Asn
Ile Glu Tyr Asn Phe Val Tyr Trp Tyr Gln Gln Leu Pro 165 170 175 Gly
Thr Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser 180 185
190 Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser
195 200 205 Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr
Tyr Cys 210 215 220 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe
Gly Thr Gly Thr 225 230 235 240 Lys Val Thr Val Leu Gly 245
<210> SEQ ID NO 25 <211> LENGTH: 246 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0108 <400>
SEQUENCE: 25 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys
Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp
Ser Ile Asp Lys Ser 20 25 30 Ser Tyr Tyr Trp Ala Trp Ile Arg Gln
Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Ala Ser Val Phe Tyr
Asp Gly Thr Ala Asp Tyr Ser Pro Ser 50 55 60 Leu Arg Ser Arg Val
Ser Met Ser Val Asp Arg Ser Leu Asn His Val 65 70 75 80 Ser Leu Arg
Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys
Ala Arg Asp Asp Gly Ser Ser Phe Asp Pro Trp Gly Arg Gly Thr 100 105
110 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125 Gly Gly Gly Gly Ser Ala Leu Ser Tyr Val Leu Thr Gln Pro
Pro Ser 130 135 140 Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser
Cys Ser Gly Ser 145 150 155 160 Ser Ser Asn Thr Gly Ser Asn Tyr Val
Tyr Trp Tyr Gln Gln Leu Pro 165 170 175 Gly Thr Ala Pro Lys Leu Leu
Ile Tyr Arg Asn Asn Gln Arg Pro Ser 180 185 190 Gly Val Pro Asp Arg
Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 195 200 205 Leu Ala Ile
Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 210 215 220 Ala
Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr 225 230
235 240 Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO 26
<211> LENGTH: 246 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGC0110 <400> SEQUENCE: 26 Gln Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Arg Tyr 20
25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Val 35 40 45 Gly Ile Ile Asn Pro Arg Gly Asp Ser Ala Asn Tyr Ala
Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser
Ala Arg Thr Val Tyr 65 70 75 80 Met Glu Met Asn Ser Leu Arg Pro Asp
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Val Gly Ala
Thr Trp Val His Trp Gly Lys Gly Thr 100 105 110 Leu Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly
Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His Ser 130 135 140 Val
Ser Gly Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly Ser 145 150
155 160 Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg
Pro 165 170 175 Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln
Arg Pro Ser 180 185 190 Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp
Arg Ser Ser Asn Ser 195 200 205 Ala Ser Leu Thr Ile Ser Gly Leu Lys
Thr Glu Asp Glu Ala Asp Tyr 210 215 220 Tyr Cys Gln Ser Ser Asp Thr
Met Phe Gln Val Phe Gly Gly Gly Thr 225 230 235 240 Lys Leu Thr Val
Leu Gly 245 <210> SEQ ID NO 27 <211> LENGTH: 246
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0114 <400> SEQUENCE: 27 Gln Met Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 20 25 30 Ser Ile Asn Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Val
Ile Ile Ser Asn Leu Gly Thr Pro Tyr Tyr Ala Gln Ser Phe 50 55 60
Gln Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Gly Thr Val Tyr 65
70 75 80 Leu Asp Val Ser Ser Leu Arg Ser Asp Asp Ser Ala Thr Tyr
Tyr Cys 85 90 95 Ala Arg Ala Arg Arg Leu Trp Gln Thr Phe Asp Ile
Trp Gly Lys Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala Gln
Ser Val Leu Thr Gln Pro Pro Ser 130 135 140 Ala Ser Gly Ala Pro Gly
Gln Arg Val Val Ile Ser Cys Ser Gly Ser 145 150 155 160 Thr Ser Ser
Ile Gly Ser Asn Thr Val Asn Trp Tyr Lys His Val Pro 165 170 175 Gly
Glu Ala Pro Lys Leu Leu Ile Tyr Ser Ser Thr Gln Arg Pro Ser 180 185
190 Gly Val Pro Gly Arg Phe Ser Gly Ser Thr Ser Gly Thr Ser Gly Ser
195 200 205 Leu Thr Ile Ser Gly Leu Gln Ser Gly Asp Glu Ala Asp Tyr
Tyr Cys 210 215 220 Ala Ala Phe Asp Asp Ser Leu Asn Gly Phe Val Phe
Gly Thr Gly Thr 225 230 235 240 Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 28 <211> LENGTH: 242 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0115 <400>
SEQUENCE: 28 Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Val Val Arg
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Asp Asp Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Gly
Gly Ser Thr Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Arg Arg Tyr Ala Leu Asp Tyr Trp Gly Lys Gly Thr Leu Val 100 105
110 Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125 Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Ala
Val Ser 130 135 140 Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln
Gly Asp Ser Leu 145 150 155 160 Arg Asn Tyr Tyr Ala Ser Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro 165 170 175 Val Leu Val Ile Tyr Gly Lys
Asn Asn Arg Pro Ser Gly Ile Pro Val 180 185 190 Arg Phe Ser Gly Ser
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr 195 200 205 Gly Thr Gln
Ala Glu Asp Gly Ala Asp Tyr Tyr Cys Asn Ser Arg Asp 210 215 220 Ser
Ser Gly Lys His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val 225 230
235 240 Leu Gly <210> SEQ ID NO 29 <211> LENGTH: 252
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0128 <400> SEQUENCE: 29 Glu Val Gln Leu Val Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Glu Ala Ser Gly Phe Ser Phe Ser Ser Tyr 20 25 30 Gly Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser
Ile Thr Ser Arg Gly Arg Gly Gly Ser Thr Tyr His Ala Asp 50 55 60
Tyr Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 65
70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr 85 90 95 Tyr Cys Ala Lys Asp Trp Ser Ala Tyr Asp Ser Val
His Leu Phe Asp 100 105 110 Tyr Trp Gly Arg Gly Thr Leu Val Thr Val
Ser Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Leu Asn Phe Met 130 135 140 Leu Thr Gln Pro His Ser
Val Ser Glu Ser Pro Gly Lys Thr Val Thr 145 150 155 160 Ile Ser Cys
Thr Arg Asn Thr Asp Asn Ile Ala Phe Asn Tyr Val Gln 165 170 175 Trp
Phe Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu 180 185
190 Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile
195 200 205 Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu
Lys Thr 210 215 220 Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp
Gly Asn Asn Leu 225 230 235 240 Val Phe Gly Gly Gly Thr Lys Leu Thr
Val Leu Gly 245 250 <210> SEQ ID NO 30 <211> LENGTH:
249 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0130 <400> SEQUENCE: 30 Glu Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Gly Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp
Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65
70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Asp Ala Arg Pro Arg Gly Ile Ala Ala Arg
Pro Leu Leu Ser 100 105 110 Tyr Trp Gly Arg Gly Thr Thr Val Thr Val
Ser Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gln Ser Val Leu Thr 130 135 140 Gln Pro Pro Ser Val Ser
Ala Ala Pro Gly Glu Lys Val Thr Ile Ser 145 150 155 160 Cys Ser Gly
Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp Tyr 165 170 175 Gln
Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser 180 185
190 Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly
195 200 205 Asn Thr Ala Ser Leu Thr Ile Ser Gly Val Gln Ala Glu Asp
Glu Ala 210 215 220 Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ala Ser Thr
Val Ile Phe Gly 225 230 235 240 Gly Gly Thr Lys Leu Thr Val Leu Gly
245 <210> SEQ ID NO 31 <211> LENGTH: 257 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGC0131
<400> SEQUENCE: 31 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Arg Lys Pro Gly Ala 1 5 10 15 Ser Val Arg Val Ser Cys Arg Ala
Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 Asp Ile Asn Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Met Asn
Pro Asn Gly Gly His Thr Gly Ser Ala Gln Lys Phe 50 55 60 Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Gly Ser Gln Trp Cys Thr Gly Gly Asn Cys Tyr Gly Thr
His 100 105 110 Tyr Tyr Tyr Met Glu Asp Trp Gly Arg Gly Thr Leu Val
Thr Val Ser 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 130 135 140 Ala Leu Asn Phe Met Leu Thr Gln Pro
His Ser Val Ser Glu Ser Pro 145 150 155 160 Gly Lys Thr Val Thr Ile
Ser Cys Thr Arg Asn Thr Asp Asn Ile Ala 165 170 175 Phe Asn Tyr Val
Gln Trp Phe Gln Gln Arg Pro Gly Ser Ser Pro Thr 180 185 190 Thr Val
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 195 200 205
Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile 210
215 220 Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser
Tyr 225 230 235 240 Asp Gly Asn Asn Leu Val Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu 245 250 255 Gly <210> SEQ ID NO 32
<211> LENGTH: 244 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGC0137 <400> SEQUENCE: 32 Glu Val
Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ser 1 5 10 15
Ser Val Arg Val Ser Cys Lys Thr Ser Gly Asp Thr Phe Arg Arg Phe 20
25 30 Thr Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45 Gly Arg Val Ile Pro Leu Tyr Asn Ser Pro Thr Tyr Ala
Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser
Thr Thr Thr Val Tyr 65 70 75 80 Met Glu Val Thr Gly Leu Thr Ser Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Pro Pro Tyr
Asn Ala Asp Phe Asp Ser Trp Gly Gln 100 105 110 Gly Thr Met Val Thr
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly
Gly Gly Gly Ser Ala Gln Ala Val Leu Thr Gln Pro Ser 130 135 140 Ser
Met Ser Val Ser Pro Gly Gln Thr Ala Ile Ile Thr Cys Ser Gly 145 150
155 160 Asn Arg Leu Gly Asp Lys Tyr Val Ser Trp Tyr Gln Gln Arg Pro
Gly 165 170 175 Gln Ser Pro Val Leu Val Ile Phe Gln Asp Asn Lys Arg
Pro Ser Gly 180 185 190 Ile Ser Glu Arg Phe Ser Gly Ser Asn Ser Gly
Asn Thr Ala Thr Leu 195 200 205 Thr Ile Ser Asp Val Glu Ala Met Asp
Glu Ala Glu Tyr Phe Cys Gln 210 215 220 Ala Trp His Ser Ser Phe Tyr
Tyr Ala Phe Gly Thr Gly Thr Lys Leu 225 230 235 240 Thr Val Leu Gly
<210> SEQ ID NO 33 <211> LENGTH: 248 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0139 <400>
SEQUENCE: 33 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu
Pro Gly Ala 1 5 10 15 Ser Met Lys Val Tyr Cys Lys Ala Ser Gly Tyr
Arg Phe Thr Arg Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Thr Ile Asn Pro Ser Asp
Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr
Met Thr Arg Asp Thr Ser Thr Arg Thr Val Tyr 65 70 75 80 Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Gly
Arg Val Glu Asp Tyr Tyr Ser Glu Ser Asn Gly Pro Ala Asp Asn 100 105
110 Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val
Leu Thr 130 135 140 Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr
Ala Ser Ile Thr 145 150 155 160 Cys Gly Gly Asn Lys Ile Gly Thr Lys
Gly Val His Trp Tyr Gln Gln 165 170 175 Lys Pro Gly Arg Ala Pro Val
Leu Val Val Tyr Asp Asp Gly Asp Arg 180 185 190 Pro Ser Gly Ile Pro
Asp Arg Phe Ser Gly Ser Asn Ser Asp Asn Thr 195 200 205 Ala Thr Leu
Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr 210 215 220 Tyr
Cys Gln Val Trp Asp Ser Asp Ser Asp Leu Gly Val Phe Gly Gly 225 230
235 240 Gly Thr Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO
34 <211> LENGTH: 243 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGC0142 <400> SEQUENCE: 34
Glu Val Gln Leu Val Gln Ser Gly Ala Ala Val Lys Lys Pro Gly Ser 1 5
10 15 Ser Val Lys Ile Ser Cys Glu Val Ser Gly Gly Ile Phe Lys Asn
Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Trp Met 35 40 45 Gly Gly Ser Ile Pro Met Tyr Gly Thr Pro Ser
Tyr Ala Pro Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Ile Ala Asp
Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg
Ser Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Glu Thr Thr
Glu Val Asp Asp Ala Phe Asp Ile Trp Gly Arg 100 105 110 Gly Thr Met
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly
Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro 130 135
140 Ser Val Ser Ala Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly
145 150 155 160 Ser Ser Ser Asn Ile Gly Asn Asn Val Val Asn Trp Tyr
Gln His Phe 165 170 175 Pro Gly Lys Ala Pro Arg Leu Leu Ile Phe Ser
Asp Ser Leu Leu Ser 180 185 190 Asp Arg Phe Ser Gly Ser Lys Ser Gly
Thr Ser Ala Ser Leu Ala Ile 195 200 205 Ser Gly Leu Gln Ser Asp Asp
Glu Ala Glu Tyr Tyr Cys Ala Ser Trp 210 215 220 Asp Asp Ser Leu Asn
Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr 225 230 235 240 Val Leu
Gly <210> SEQ ID NO 35 <211> LENGTH: 243 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGC0145
<400> SEQUENCE: 35 Glu Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Glu Val
Ser Gly Gly Ile Phe Lys Asn Tyr 20 25 30 Ala Ile Ser Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ser Ile
Pro Met Tyr Gly Thr Pro Ser Tyr Ala Pro Lys Phe 50 55 60 Gln Gly
Arg Val Thr Ile Ile Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 85
90 95 Ala Arg Glu Thr Thr Glu Val Asp Asp Ala Phe Asn Ile Trp Gly
Arg 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val
Leu Thr Gln Pro Pro 130 135 140 Ser Val Ser Ala Ala Pro Arg Gln Arg
Val Thr Ile Ser Cys Ser Gly 145 150 155 160 Ser Ser Ser Asn Ile Gly
Asn Asn Val Val Asn Trp Tyr Gln His Phe 165 170 175 Pro Gly Lys Ala
Pro Arg Leu Leu Ile Phe Pro Asp Ser Leu Leu Ser 180 185 190 Asp Arg
Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 195 200 205
Ser Gly Leu Gln Ser Asp Asp Glu Ala Glu Tyr Tyr Cys Ala Ser Trp 210
215 220 Asp Asp Ser Leu Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu
Thr 225 230 235 240 Val Leu Gly <210> SEQ ID NO 36
<211> LENGTH: 249 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGC0150 <400> SEQUENCE: 36 Gln Val
Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 20
25 30 Asn Tyr Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu
Trp 35 40 45 Ile Gly Glu Ile Tyr His Asp Gly Ser Thr Asn Tyr Asn
Pro Ser Leu 50 55 60 Lys Ser Arg Val Thr Met Ser Ala Asp Lys Ser
Lys Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu Ser Ser Val Thr Ala Ala
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Pro Ser Tyr
Ser Ser Gly Trp Tyr Ser Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln 130 135 140 Pro
Pro Ser Ala Ser Gly Thr Pro Gly Arg Arg Val Thr Ile Ser Cys 145 150
155 160 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn Trp Tyr
Gln 165 170 175 Gln Leu Pro Gly Thr Ala Pro Lys Ile Val Met Tyr Ser
Thr Asp Gln 180 185 190 Arg Thr Ser Gly Ala Pro Asp Arg Phe Ser Gly
Ser Lys Ser Gly Thr 195 200 205 Ser Ala Ser Leu Ala Ile Thr Gly Leu
Gln Ser Glu Asp Glu Ala Asp 210 215 220 Tyr Phe Cys Ala Thr Trp Asp
Asp Ser Pro Asn Ala Val Val Phe Gly 225 230 235 240 Gly Gly Thr Lys
Leu Thr Val Leu Gly 245 <210> SEQ ID NO 37 <211>
LENGTH: 251 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGC0153 <400> SEQUENCE: 37 Glu Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Asp 20 25 30 Tyr Leu
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45
Gly Trp Ile Asn Pro Asn Thr Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50
55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala
Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Ile
Tyr Tyr Cys 85 90 95 Ala Arg Ala Arg Tyr Tyr Tyr Asp Ser Thr Ser
Tyr Pro Phe Asp Tyr 100 105 110 Trp Gly Arg Gly Thr Leu Val Thr Val
Ser Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Leu Asn Phe Met Leu 130 135 140 Thr Gln Pro His Ser
Val Ser Glu Ser Pro Gly Lys Thr Val Thr Leu 145 150 155 160 Ser Cys
Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp Tyr Val Gln Trp 165 170 175
Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu Val Ile Phe Glu Asp 180
185 190 Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile
Asp 195 200 205 Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu
Gln Ser Glu 210 215 220 Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp
Asp Asn Arg Gln Val 225 230 235 240 Phe Gly Gly Gly Thr Lys Val Thr
Val Leu Gly 245 250 <210> SEQ ID NO 38 <211> LENGTH:
245 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0154 <400> SEQUENCE: 38 Gln Val Gln Leu Val Gln Ser Gly
Ala Glu Val Arg Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys
Thr Thr Ser Glu Asn Thr Phe Arg Arg Ser 20 25 30 Ser Phe Ser Trp
Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg
Ile Ile Pro Ile Ile His Ser Glu Thr Tyr Ala Gln Asn Phe 50 55 60
Gln Gly Arg Val Thr Met Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 65
70 75 80 Val Glu Val Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Asp Ser Pro Pro Tyr Asn Ala Asp Phe Asp
Phe Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala
Leu Ser Tyr Glu Leu Thr Gln Pro 130 135 140 Pro Ser Val Ser Val Ser
Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser 145 150 155 160 Gly Asp Asn
Leu Gly Asp Lys Tyr Val Ser Trp Tyr Gln Gln Arg Pro 165 170 175 Gly
Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Val Lys Arg Pro Ser 180 185
190 Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr
195 200 205 Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr
Tyr Cys 210 215 220 Gln Ala Trp Asp Ser Asn Thr Ser Tyr Val Phe Gly
Thr Gly Thr Gln 225 230 235 240 Leu Thr Val Leu Ser 245 <210>
SEQ ID NO 39 <211> LENGTH: 253 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0157 <400>
SEQUENCE: 39 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly
Thr Phe Asn Ser Ser 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu
Gly Ile Ala Asn Tyr Ala Gln Asn Phe 50 55 60 Gln Asp Arg Val Thr
Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu
Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr
Arg Asp Tyr Val Asp Pro Asp Met Leu Thr Ala Gly Tyr Tyr Phe 100 105
110 Asp Gln Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
115 120 125 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu
Asn Phe 130 135 140 Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro
Gly Lys Thr Val 145 150 155 160 Thr Ile Ser Cys Thr Arg Asn Thr Asp
Asn Ile Ala Phe Asn Tyr Val 165 170 175 Gln Trp Phe Gln Gln Arg Pro
Gly Ser Ser Pro Thr Thr Val Ile Tyr 180 185 190 Glu Asp Asn Gln Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 195 200 205 Ile Asp Ser
Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys 210 215 220 Thr
Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Asn Asn 225 230
235 240 Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250
<210> SEQ ID NO 40 <211> LENGTH: 247 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0162 <400>
SEQUENCE: 40 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ala Gly Phe
Arg Phe Ser Gly Asp 20 25 30 Tyr Leu His Trp Leu Arg Gln Val Pro
Gly Gln Gly Pro Glu Trp Met 35 40 45 Gly Trp Ile Asn Leu Ser Ser
Gly Gly Thr Asn Tyr Gly Glu Lys Phe 50 55 60 Gln Gly Arg Val Thr
Met Thr Arg Asp Arg Pro Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Ile
Lys Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Glu Ser Pro Val Val Glu Ala Met Asp Val Trp Gly Arg Gly 100 105
110 Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
115 120 125 Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln
Pro His 130 135 140 Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile
Ser Cys Thr Arg 145 150 155 160 Ser Ser Asp Asn Ile Ala Phe Asn Tyr
Val Gln Trp Tyr Gln Gln Arg 165 170 175 Pro Gly Ser Ala Pro Thr Thr
Leu Ile Tyr Glu Asp Asn Gln Arg Pro 180 185 190 Ser Gly Val Pro Asp
Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn 195 200 205 Ser Ala Ser
Leu Thr Ile Ser Asn Leu Lys Thr Glu Asp Glu Ala Asp 210 215 220 Tyr
Tyr Cys Gln Ser Tyr Asp Gly Ser Asn Tyr Val Phe Gly Thr Gly 225 230
235 240 Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 41
<211> LENGTH: 245 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGC0164 <400> SEQUENCE: 41 Glu Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20
25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45 Gly Trp Ile Asn Pro Lys Ser Gly Gly Thr Asn Tyr Pro
Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser
Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Thr Gly Asp
Phe Phe Asp Tyr Trp Gly Arg Gly Thr 100 105 110 Leu Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly
Gly Ser Ala Gln Pro Val Leu Thr Gln Pro Pro Ser Ala 130 135 140 Ser
Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser 145 150
155 160 Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His
Pro 165 170 175 Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Lys
Arg Pro Ser 180 185 190 Gly Val Pro Asp Arg Phe Ser Ala Ser Lys Ser
Gly Asn Thr Ala Ser 195 200 205 Leu Thr Val Ser Gly Leu Gln Ala Glu
Asp Glu Ala Tyr Tyr Tyr Cys 210 215 220 Ser Ser Tyr Ala Gly Ser Asn
Asn Ser Val Phe Gly Gly Gly Thr Lys 225 230 235 240 Leu Thr Val Leu
Gly 245 <210> SEQ ID NO 42 <211> LENGTH: 246
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0169 <400> SEQUENCE: 42 Gln Val Gln Leu Gln Glu Ser Gly
Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 20 25 30 Gly Met His Trp
Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 35 40 45 Ala Val
Ile Trp Tyr Asp Gly Ser Arg Gln Tyr Tyr Gly Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr
Tyr Cys 85 90 95 Ala Arg Asp Pro Ser Leu Ala Pro Val Tyr Gln Phe
Asp Tyr Trp Gly 100 105 110 Arg Gly Thr Met Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser
Ala Leu Asp Val Val Met Thr Gln 130 135 140 Ser Pro Ser Ser Leu Ser
Ala Ser Val Gly Glu Arg Val Thr Ile Thr 145 150 155 160 Cys Arg Ala
Ser Gln Asn Ile Phe Asn Asn Leu Asn Trp Tyr Gln Gln 165 170 175 Lys
Pro Gly Asn Ala Pro Ser Leu Leu Ile Ser Asp Ala Ser Ser Leu 180 185
190 Gln Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
195 200 205 Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Leu Gly
Thr Tyr 210 215 220 Tyr Cys Gln Gln Ser Tyr Thr Ile Pro Pro Thr Phe
Gly Gln Gly Thr 225 230 235 240 Arg Leu Glu Ile Lys Arg 245
<210> SEQ ID NO 43 <211> LENGTH: 248 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0175 <400>
SEQUENCE: 43 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
Thr Phe Thr Ser Tyr 20 25 30 Gly Ile Asn Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Pro Tyr Asn
Tyr Asn Thr Asn Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr
Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Glu Glu Thr Gly Ser Tyr His Gly Phe Asp Tyr Trp Gly Arg 100 105
110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr
Gln Pro 130 135 140 His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr
Ile Ser Cys Thr 145 150 155 160 Ala Ser Ser Gly Asn Ile Ala Phe Asn
Tyr Val Gln Trp Tyr Gln Gln 165 170 175 Arg Pro Gly Ser Ala Pro Thr
Ile Val Ile Gln Glu Asp Asn Gln Arg 180 185 190 Pro Ser Gly Val Pro
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser 195 200 205 Asn Ser Ala
Ser Leu Thr Ile Ser Gly Leu Lys Ala Glu Asp Glu Gly 210 215 220 Asp
Tyr Tyr Cys Gln Ser Tyr Asp Lys Tyr Tyr Arg Ile Phe Gly Gly 225 230
235 240 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
44 <211> LENGTH: 243 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0102 <400> SEQUENCE: 44
Glu Val Gln Leu Val Gln Ser Gly Gly Glu Val Lys Lys Pro Gly Asp 1 5
10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser His
Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Trp Met 35 40 45 Gly Trp Thr Ser Ala Tyr Ser Gly Ser Thr Asn
Tyr Ala Gln Lys Phe 50 55 60 Arg Gly Arg Val Thr Met Thr Thr Asp
Thr Ser Thr Gly Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg
Pro Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Gly Arg Gly Asp Ser
Tyr Gly Ser Ile Pro Ala Asp Tyr Trp Gly Arg 100 105 110 Gly Thr Leu
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly
Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser 130 135
140 Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
145 150 155 160 Ser Gln Asp Ile Thr Asn Asp Leu Ala Trp Tyr Gln Gln
Lys Pro Gly 165 170 175 Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser
Thr Leu Gln Tyr Gly 180 185 190 Val Pro Thr Arg Phe Ser Gly Ser Gly
Ser Gly Thr Asn Phe Ser Leu 195 200 205 Thr Ile Ser Ser Leu Gln Pro
Glu Asp Phe Ala Thr Tyr Phe Cys Gln 210 215 220 Gln Ser His Ser Phe
Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 225 230 235 240 Ile Lys
Arg <210> SEQ ID NO 45 <211> LENGTH: 254 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGD0108
<400> SEQUENCE: 45 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asn Tyr Tyr Asp Phe Trp Arg Gly Tyr Gln Ser Gln Pro
Asn 100 105 110 Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val
Ser Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Gln 130 135 140 Ser Val Leu Thr Gln Pro Pro Ser Ala
Ser Gly Thr Pro Glu Gln Arg 145 150 155 160 Val Thr Ile Ser Cys Ser
Gly Ser Ser Ser Asn Ile Gly Tyr Asn Tyr 165 170 175 Val Tyr Trp Phe
Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 180 185 190 Tyr Thr
Asn Asn Leu Arg Pro Ser Gly Val Pro Asp Gln Phe Ser Gly 195 200 205
Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser 210
215 220 Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
Ser 225 230 235 240 Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val
Leu Gly 245 250 <210> SEQ ID NO 46 <211> LENGTH: 248
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGD0112 <400> SEQUENCE: 46 Glu Val Gln Leu Leu Glu Ser Gly
Gly Ser Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Glu Asp Pro Trp Ser Asp Ala Phe Asp Leu
Trp Gly Arg Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala Leu
Asn Phe Met Leu Thr Gln Pro His 130 135 140 Ser Val Ser Glu Ser Pro
Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 145 150 155 160 Ser Ser Gly
Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165 170 175 Pro
Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro 180 185
190 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn
195 200 205 Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu
Ala Asp 210 215 220 Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn His Trp
Val Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 47 <211> LENGTH: 248 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGD0117 <400>
SEQUENCE: 47 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Asp Arg Gly Ser Pro Asp Ala Phe Asp Ile Trp Gly Gln Gly 100 105
110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
115 120 125 Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln
Pro His 130 135 140 Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile
Ser Cys Thr Gly 145 150 155 160 Ser Ser Gly Ser Ile Ala Ser Asn Tyr
Val Gln Trp Tyr Gln Gln Arg 165 170 175 Pro Gly Ser Ala Pro Thr Thr
Val Ile Tyr Glu Tyr Ser Gln Arg Pro 180 185 190 Ser Gly Val Pro Asp
Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn 195 200 205 Ser Ala Ser
Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp 210 215 220 Tyr
Tyr Cys Gln Ser Phe Asp Thr Asn Asn Gln Gly Val Phe Gly Gly 225 230
235 240 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
48 <211> LENGTH: 245 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0119 <400> SEQUENCE: 48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Ile Ser
Ser Ser Trp Thr Leu Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Met
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly
Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Thr Leu Thr Gln Ser 130 135
140 Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys
145 150 155 160 Arg Ala Ser Gln Ser Ile Gly Ser Leu Leu Ala Trp Tyr
Gln Gln Arg 165 170 175 Pro Gly Gln Ala Pro Arg Leu Val Ile Ser Asp
Ala Ser Asn Arg Ala 180 185 190 Ser Gly Ile Pro Ala Arg Phe Arg Gly
Ser Gly Ser Gly Thr Asp Phe 195 200 205 Thr Leu Thr Ile Ser Ser Leu
Ala Pro Glu Asp Phe Ala Val Tyr Tyr 210 215 220 Cys His Gln Arg Ser
Met Trp Pro Leu Ser Phe Gly Gly Gly Thr Lys 225 230 235 240 Val Glu
Ile Lys Arg 245 <210> SEQ ID NO 49 <211> LENGTH: 244
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGD0121 <400> SEQUENCE: 49 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Ile His Asn Trp Asn Asp Met Phe Asp Tyr
Trp Gly Arg Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala Leu
Asp Ile Gln Leu Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser
Val Gly Asp Lys Val Thr Ile Ala Cys Arg 145 150 155 160 Pro Ser Gln
Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly
Lys Pro Pro Arg Leu Leu Ile Tyr Asp Val Ser Thr Leu Glu Ser 180 185
190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr
195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
Tyr Cys 210 215 220 Gln Gln Phe Asp Asn Tyr Pro Val Thr Phe Gly Gln
Gly Thr Arg Leu 225 230 235 240 Glu Ile Lys Arg <210> SEQ ID
NO 50 <211> LENGTH: 247 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0122 <400> SEQUENCE: 50
Glu Val Gln Leu Leu Glu Ser Gly Glu Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Pro Tyr
Tyr Asp Ser Ser Gly Tyr Tyr Pro Phe Ser Tyr 100 105 110 Trp Gly Lys
Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr 130 135
140 Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Thr
145 150 155 160 Cys Gly Gly Asp Phe Ala Thr Lys Ser Val Asn Trp Tyr
Gln Arg Lys 165 170 175 Pro Gly Gln Ala Pro Val Thr Val Ile Tyr Tyr
Ser Thr Glu Arg Pro 180 185 190 Pro Ala Ile Pro Glu Arg Phe Ser Gly
Ser Asn Thr Gly Ser Thr Ala 195 200 205 Thr Leu Thr Ile Ser Arg Val
Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 210 215 220 Cys Gln Val Trp Asp
Ser Phe Thr Asp His Arg Leu Phe Gly Gly Gly 225 230 235 240 Thr Lys
Leu Thr Val Leu Gly 245 <210> SEQ ID NO 51 <211>
LENGTH: 248 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGD0123 <400> SEQUENCE: 51 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Tyr Ala Ser Gly Leu Leu Asp Ala Phe
Asp Ile Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser
Ala Gln Ser Val Leu Thr Gln Pro Pro 130 135 140 Ser Val Ser Gly Ala
Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly 145 150 155 160 Ser Ser
Ser Asn Ile Gly Ala Gly Asn Asp Val Asn Trp Tyr Gln Gln 165 170 175
Val Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Gly Thr Thr Tyr Arg 180
185 190 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr
Ser 195 200 205 Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu
Ala Asp Tyr 210 215 220 Phe Cys Gln Ser Asp Asp Ser Ser Leu Ser Gly
Ser Val Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu Thr Val Leu Gly
245 <210> SEQ ID NO 52 <211> LENGTH: 254 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGD0124
<400> SEQUENCE: 52 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Pro Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Val Lys Asp Thr Glu Phe Tyr Tyr Asp Phe Trp Ser Asn Asp Gly
Gly 100 105 110 Trp Phe Asp Thr Trp Gly Arg Gly Thr Met Val Thr Val
Ser Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Gln 130 135 140 Ala Val Leu Thr Gln Pro Ser Ser Thr
Ser Gly Ser Pro Gly Gln Arg 145 150 155 160 Val Thr Ile Ser Cys Ser
Gly Ser Asn Ser Asn Ile Gly Ser Asn Tyr 165 170 175 Val Tyr Trp Tyr
Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 180 185 190 Tyr Arg
Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 195 200 205
Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser 210
215 220 Gly Asp Glu Gly Asp Tyr His Cys Ala Thr Trp Asp Asp Arg Leu
Tyr 225 230 235 240 Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val
Leu Gly 245 250 <210> SEQ ID NO 53 <211> LENGTH: 245
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGD0130 <400> SEQUENCE: 53 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Lys Gly Ile Ser Ser Ser Trp Thr Leu Phe Asp
Tyr Trp Gly Gln 100 105 110 Gly Thr Met Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala
Leu Glu Thr Thr Leu Thr Gln Ser 130 135 140 Pro Ala Thr Leu Ser Leu
Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys 145 150 155 160 Arg Ala Ser
Gln Ser Ile Gly Ser Leu Leu Ala Trp Tyr Gln Gln Arg 165 170 175 Pro
Gly Gln Ala Pro Arg Leu Val Ile Ser Asp Ala Ser Asn Arg Ala 180 185
190 Ser Gly Ile Pro Ala Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe
195 200 205 Thr Leu Thr Ile Ser Ser Leu Ala Pro Glu Asp Phe Ala Val
Tyr Tyr 210 215 220 Cys Gln Gln Arg Ser Met Trp Pro Leu Ser Phe Gly
Gly Gly Thr Lys 225 230 235 240 Val Glu Ile Lys Arg 245 <210>
SEQ ID NO 54 <211> LENGTH: 249 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGD0135 <400>
SEQUENCE: 54 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Tyr Ala Ser Gly Leu Val Asp Ala Phe Asp Met Trp Gly Arg 100 105
110 Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Gln Ala Val Leu Thr Gln
Pro Ser 130 135 140 Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile
Ser Cys Thr Gly 145 150 155 160 Arg Ser Ser Asn Ile Gly Ala Gly Tyr
Asp Val Asn Trp Tyr Gln Gln 165 170 175 Leu Pro Gly Ala Ala Pro Lys
Leu Leu Ile Tyr Asp Asn Asn Tyr Arg 180 185 190 Pro Ser Gly Val Pro
Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 195 200 205 Ala Ser Leu
Ala Ile Thr Gly Leu Gln Ala Asp Asp Glu Ala Val Tyr 210 215 220 Tyr
Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Glu Val Phe Gly 225 230
235 240 Gly Gly Thr Lys Val Thr Val Leu Gly 245 <210> SEQ ID
NO 55 <211> LENGTH: 251 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0136 <400> SEQUENCE: 55
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Ser Leu
Gly Leu Trp Phe Gly Leu Gly His Phe Glu Asn 100 105 110 Trp Gly Arg
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu 130 135
140 Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Leu
145 150 155 160 Ser Cys Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp Tyr
Val Gln Trp 165 170 175 Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu
Val Ile Phe Glu Asp 180 185 190 Asp Gln Arg Pro Ser Gly Val Pro Asp
Arg Phe Ser Gly Ser Ile Asp 195 200 205 Ser Thr Ser Asn Ser Ala Ser
Leu Thr Ile Ser Gly Leu Gln Ser Glu 210 215 220 Asp Glu Gly Asp Tyr
Tyr Cys Gln Thr Tyr Asp Asp Asn Arg Gln Val 225 230 235 240 Phe Gly
Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250 <210> SEQ ID NO
56 <211> LENGTH: 248 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0141 <400> SEQUENCE: 56
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Leu
Tyr Gly Asp Leu Glu Tyr Phe Gln His Trp Gly 100 105 110 Arg Gly Thr
Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly
Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro 130 135
140 Ser Ser Ala Ser Gly Asn Pro Gly Gln Arg Val Thr Ile Ser Cys Ser
145 150 155 160 Gly Ser Ser Ser Asn Ile Gly Asp Asn Pro Val Asp Trp
Tyr Gln His 165 170 175 Val Pro Gly Arg Ala Pro Lys Leu Leu Ile Phe
Arg Asp Asn Gln Arg 180 185 190 Pro Ser Gly Val Pro Asp Arg Phe Ser
Gly Thr Lys Ser Gly Thr Ser 195 200 205 Ala Ser Leu Ala Ile Ser Gly
Leu Gln Ser Glu Asp Glu Ala Asp Tyr 210 215 220 Tyr Cys Glu Ala Trp
Asp Asp Ser Leu Asp Ser Pro Val Phe Gly Gly 225 230 235 240 Gly Thr
Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 57 <211>
LENGTH: 253 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGD0143 <400> SEQUENCE: 57 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg His Arg Gly Ile Thr Met Tyr Gly Val
Leu Arg Pro Gly Asp 100 105 110 Met Asp Val Trp Gly Arg Gly Thr Leu
Val Thr Val Ser Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ala Gln Ala 130 135 140 Val Leu Thr Gln Pro
Ser Ser Ala Ser Ala Thr Pro Gly Gln Arg Val 145 150 155 160 Thr Ile
Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Ser Val 165 170 175
Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 180
185 190 Thr Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly
Ser 195 200 205 Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
Gln Ser Glu 210 215 220 Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp
Asp Thr Leu Thr Gly 225 230 235 240 Pro Val Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu Gly 245 250 <210> SEQ ID NO 58 <211>
LENGTH: 242 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGD0145 <400> SEQUENCE: 58 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Arg Tyr Arg Tyr Phe Asp Asn Trp Gly
Gln Gly Thr Met Val 100 105 110 Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Ala Leu Ser Ser
Glu Leu Thr Gln Asp Pro Ala Val Ser 130 135 140 Val Ala Leu Gly Gln
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 145 150 155 160 Arg Thr
Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 165 170 175
Val Leu Val Phe Tyr Gly Lys Lys Asn Arg Pro Ser Gly Ile Pro Asp 180
185 190 Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ser Ser Leu Thr Ile
Thr 195 200 205 Gly Ala Gln Ala Glu Asp Asp Ala Asp Tyr Tyr Cys Asn
Ser Arg Asp 210 215 220 Ser Ser Gly Asn His Leu Val Phe Gly Gly Gly
Thr Lys Leu Thr Val 225 230 235 240 Leu Gly <210> SEQ ID NO
59 <211> LENGTH: 251 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0153 <400> SEQUENCE: 59
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Leu Arg Gly
Ser Thr Arg Trp Glu Asp Phe Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly
Lys Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125 Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Thr Val Val 130 135
140 Ile Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly Thr Val Thr Leu
145 150 155 160 Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Thr Tyr
Tyr Pro Ser 165 170 175 Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg
Thr Leu Ile Tyr Asn 180 185 190 Thr Asn Thr Arg Ser Ser Gly Val Pro
Asp Arg Phe Ser Gly Ser Ile 195 200 205 Leu Gly Asn Lys Ala Ala Leu
Thr Ile Thr Gly Ala Gln Ala Asp Asp 210 215 220 Glu Ser Asp Tyr Tyr
Cys Val Leu Tyr Leu Gly Ser Gly Ile Trp Val 225 230 235 240 Phe Gly
Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250 <210> SEQ ID NO
60 <211> LENGTH: 247 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0154 <400> SEQUENCE: 60
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Pro Tyr
Tyr Asp Ser Ser Gly Tyr Tyr Pro Phe Ser Tyr 100 105 110 Trp Gly Arg
Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Val Thr 130 135
140 Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Thr Ile Thr
145 150 155 160 Cys Gly Gly Asp Phe Ala Thr Lys Ser Val Asn Trp Tyr
Gln Arg Lys 165 170 175 Pro Gly Gln Ala Pro Val Thr Val Ile Tyr Tyr
Asn Thr Glu Arg Pro 180 185 190 Pro Ala Ile Pro Glu Arg Phe Ser Gly
Ser Asn Thr Gly Ser Thr Ala 195 200 205 Thr Leu Thr Ile Ser Arg Val
Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 210 215 220 Cys Gln Val Trp Asp
Ser Phe Thr Asp His Arg Leu Phe Gly Gly Gly 225 230 235 240 Thr Lys
Val Thr Val Leu Gly 245 <210> SEQ ID NO 61 <211>
LENGTH: 251 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGD0169 <400> SEQUENCE: 61 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Val Arg Arg Val Pro Phe Gly
Ser Gly Ser Tyr Leu 100 105 110 Asn Pro Phe Asp Trp Gly Gln Gly Thr
Met Val Thr Val Ser Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Leu 130 135 140 Ser Tyr Glu Leu Thr
Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 145 150 155 160 Thr Ala
Ser Ile Thr Cys Thr Gly Asp Lys Leu Ala Glu Lys Tyr Val 165 170 175
Ser Trp Tyr Gln Gln Lys Thr Gly Arg Ser Pro Val Leu Val Ile Tyr 180
185 190 Gln Asp Asp Arg Arg Pro Ser Glu Ile Pro Glu Arg Phe Ser Gly
Ser 195 200 205 Asn Ser Gly Asn Thr Ala Thr Leu Thr Val Ser Gly Ala
Gln Ser Met 210 215 220 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp
Ser Asn Thr Val Ile 225 230 235 240 Phe Gly Gly Gly Thr Lys Val Thr
Val Leu Gly 245 250 <210> SEQ ID NO 62 <211> LENGTH:
249 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGD0170 <400> SEQUENCE: 62 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Gln Gln Pro Phe Thr Asp Ala Phe Asp Ile
Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala Leu
Asn Phe Met Leu Thr Gln Pro His 130 135 140 Ser Val Ser Glu Ser Pro
Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 145 150 155 160 Ser Ser Gly
Asn Ile Ala Asn Asn Tyr Val Gln Trp Phe Gln Gln Arg 165 170 175 Pro
Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro 180 185
190 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn
195 200 205 Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu
Ala Asp 210 215 220 Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Leu Tyr
Val Val Phe Gly 225 230 235 240 Gly Gly Thr Lys Val Thr Val Leu Gly
245 <210> SEQ ID NO 63 <211> LENGTH: 248 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGD0180
<400> SEQUENCE: 63 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Leu Gly Asn Trp Asn Asp Val Phe Asp Tyr Trp Gly Gln
Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met
Leu Thr Gln Pro His 130 135 140 Ser Val Ser Glu Ser Pro Gly Lys Thr
Val Thr Ile Ser Cys Thr Arg 145 150 155 160 Ser Ser Gly Ser Ile Ala
Asn Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165 170 175 Pro Gly Ser Ala
Pro Thr Thr Val Ile Phe Glu Asp Asp Gln Arg Pro 180 185 190 Ser Gly
Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn 195 200 205
Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Asp Asp Glu Ala Asp 210
215 220 Tyr Tyr Cys Gln Ser Asn Asp Gly Thr Asn Pro Trp Val Phe Gly
Gly 225 230 235 240 Gly Thr Lys Leu Thr Val Leu Gly 245 <210>
SEQ ID NO 64 <211> LENGTH: 248 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGD0182 <400>
SEQUENCE: 64 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Glu Asp Pro Trp Ser Asp Ala Phe Asp Leu Trp Gly Lys Gly 100 105
110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
115 120 125 Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln
Pro His 130 135 140 Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile
Ser Cys Thr Gly 145 150 155 160 Ser Ser Gly Ser Ile Ala Asn Asn Tyr
Val Gln Trp Tyr Gln Gln Arg 165 170 175 Pro Gly Ser Ala Pro Thr Thr
Val Ile Tyr Glu Asp Asn Gln Arg Pro 180 185 190 Ser Gly Val Pro Asp
Arg Phe Ser Ala Ser Ile Asp Arg Ser Ser Asn 195 200 205 Ser Ala Ser
Leu Thr Ile Ser Gly Leu Met Thr Glu Asp Glu Ala Asp 210 215 220 Tyr
Tyr Cys Gln Ser Tyr Asp Ser Asn Asn His Trp Val Phe Gly Gly 225 230
235 240 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
65 <211> LENGTH: 245 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0183 <400> SEQUENCE: 65
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Ser Asp
Ser Ser Asn Trp Phe Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Met
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly
Ser Gly Gly Gly Gly Ser Ala Leu Asp Val Val Met Thr Gln Ser 130 135
140 Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys
145 150 155 160 Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala Trp Tyr
Gln Gln Lys 165 170 175 Pro Gly Gln Ala Pro Arg Leu Leu Met Tyr Asp
Ala Ser Asn Arg Ala 180 185 190 Thr Gly Ile Pro Ala Arg Phe Ser Gly
Ser Gly Ser Gly Thr Asp Phe 195 200 205 Thr Leu Thr Ile Ser Ser Leu
Glu Pro Glu Asp Phe Ala Val Tyr Tyr 210 215 220 Cys Gln Gln Arg Ser
Asn Trp Pro Ile Thr Phe Gly Gln Gly Thr Arg 225 230 235 240 Leu Glu
Ile Lys Arg 245 <210> SEQ ID NO 66 <211> LENGTH: 242
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGD0193 <400> SEQUENCE: 66 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Arg Arg Tyr Ala Leu Asp Tyr Trp Gly Arg
Gly Thr Leu Val 100 105 110 Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Ala Leu Ser Ser Glu
Leu Thr Gln Asp Pro Ala Val Ser 130 135 140 Val Ala Leu Gly Gln Thr
Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 145 150 155 160 Arg Asn Tyr
Tyr Pro Ser Trp Tyr Gln Gln Ser Pro Gly Gln Ala Pro 165 170 175 Val
Leu Val Ile Tyr Gly Lys Asn Lys Arg Pro Ser Gly Ile Pro Asp 180 185
190 Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr
195 200 205 Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser
Arg Asp 210 215 220 Ser Ser Gly Asn His Leu Leu Phe Gly Gly Gly Thr
Lys Leu Thr Val 225 230 235 240 Leu Gly <210> SEQ ID NO 67
<211> LENGTH: 247 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGD0195 <400> SEQUENCE: 67 Glu Val
Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20
25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Pro Tyr Tyr Asp
Ser Ser Gly Tyr Tyr Pro Phe Ser Tyr 100 105 110 Trp Gly Gln Gly Thr
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr 130 135 140 Gln
Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Thr Ile Thr 145 150
155 160 Cys Gly Gly Asp Phe Ala Thr Lys Asn Val Asn Trp Tyr Gln Arg
Lys 165 170 175 Pro Gly Gln Ala Pro Val Thr Val Ile Tyr Tyr Asn Thr
Glu Arg Pro 180 185 190 Ser Ala Ile Pro Glu Arg Phe Ser Gly Ser Asn
Thr Gly Ser Thr Ala 195 200 205 Thr Leu Thr Ile Ser Arg Val Glu Ala
Gly Asp Glu Ala Asp Tyr Tyr 210 215 220 Cys Gln Val Trp Asp Ser Phe
Thr Asp His Arg Leu Phe Gly Gly Gly 225 230 235 240 Thr Lys Leu Thr
Val Leu Gly 245 <210> SEQ ID NO 68 <211> LENGTH: 762
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(762) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0101 scFv protein <400> SEQUENCE: 68 gag gtg cag
ctg gtg gag act ggg gga ggc gtg gtc cag cct ggg agg 48 Glu Val Gln
Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 tcc
cag aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc gac tat 96 Ser
Gln Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25
30 gct atg cac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gta tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aaa gga atc agg tat tac tat
gat agt agt ggt tat tac gat ggg 336 Ala Lys Gly Ile Arg Tyr Tyr Tyr
Asp Ser Ser Gly Tyr Tyr Asp Gly 100 105 110 tac tac tac tac ggt atg
gac gtc tgg ggc caa ggg acc acg gtc acc 384 Tyr Tyr Tyr Tyr Gly Met
Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 gtc tcc tca ggt
gga ggc ggt tca ggc gga ggt ggc agc ggc ggt ggc 432 Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 130 135 140 gga tcg
tct gag ctg act cag gac cct gct gtg tct gtg gcc ttg gga 480 Gly Ser
Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 145 150 155
160 cag aca gtc agg atc act tgc caa gga gac agt ctc aga agc tat tac
528 Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr
165 170 175 aca aac tgg ttc cag cag agg cca gga cag gcc cct cta ctt
gtc gtc 576 Thr Asn Trp Phe Gln Gln Arg Pro Gly Gln Ala Pro Leu Leu
Val Val 180 185 190 tat gct aaa aat aag cgg ccc tca ggg atc cca gac
cga ttc tct ggc 624 Tyr Ala Lys Asn Lys Arg Pro Ser Gly Ile Pro Asp
Arg Phe Ser Gly 195 200 205 tcc agc tca gga aac aca gct tcc ttg acc
atc act ggg gct cag gcg 672 Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr
Ile Thr Gly Ala Gln Ala 210 215 220 gaa gat gag gct gac tat tac tgt
cat tcc cgg gac agc agt ggt aac 720 Glu Asp Glu Ala Asp Tyr Tyr Cys
His Ser Arg Asp Ser Ser Gly Asn 225 230 235 240 cat gtg ctt ttc ggc
gga ggg acc aag ctg acc gtc cta ggt 762 His Val Leu Phe Gly Gly Gly
Thr Lys Leu Thr Val Leu Gly 245 250 <210> SEQ ID NO 69
<211> LENGTH: 753 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(753) <223> OTHER INFORMATION:
Polynucleotide encoding RGB0102 scFv protein <400> SEQUENCE:
69 cag gtg cag ctg gta cag tct ggg gct gag gtg aag aag cct ggg gcc
48 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 tca gtg aag gtc tcc tgc aag gct tct gga tac acc ttc acc
gac tac 96 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Asp Tyr 20 25 30 tat ata cac tgg gtg cga cag gcc cct gga caa ggg
ctt gag tgg atg 144 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Met 35 40 45 gga tgg atc aac cct aaa agt ggt gac aca
aac tat gca cag aag ttt 192 Gly Trp Ile Asn Pro Lys Ser Gly Asp Thr
Asn Tyr Ala Gln Lys Phe 50 55 60 cag ggc agg gtc acc atg gcc agg
gac acg tcc atg agc acg gcc tcc 240 Gln Gly Arg Val Thr Met Ala Arg
Asp Thr Ser Met Ser Thr Ala Ser 65 70 75 80 gtg gaa ctg aga agg ttg
aca tct gac gac acg gcc gtg tat tac tgt 288 Val Glu Leu Arg Arg Leu
Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg agg aac tcg
ttc gac ttt ggg agt ggc tat ggg ctc ttc tac cag 336 Ala Arg Asn Ser
Phe Asp Phe Gly Ser Gly Tyr Gly Leu Phe Tyr Gln 100 105 110 tac att
atg gac gtc tgg ggc caa gga acc ctg gtc acc gtc tcc tca 384 Tyr Ile
Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125
ggt gga ggc ggt tca ggc gga ggt ggc agc ggc ggt ggc gga tcg gac 432
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 130
135 140 atc cag atg acc cag tct cca tcc ttc ctg tct gca tct gta gga
gac 480 Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
Asp 145 150 155 160 aga gtc acc atc act tgc cgg gcc agt cag ggc att
aac aat tat tta 528 Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile
Asn Asn Tyr Leu 165 170 175 gcc tgg tat cag caa aaa cca ggg aga gcc
cct aag ctc ctg atc tac 576 Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala
Pro Lys Leu Leu Ile Tyr 180 185 190 gct gca tcc agt tta caa agt ggg
gtc cca tca agg ttc agc ggc agt 624 Ala Ala Ser Ser Leu Gln Ser Gly
Val Pro Ser Arg Phe Ser Gly Ser 195 200 205 gga tct ggc aca gat ttc
act ctc acc atc agc agc ctg cag cct gaa 672 Gly Ser Gly Thr Asp Phe
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 210 215 220 gat ttt gca act
tat tac tgt ctc caa gat tcc gat tat ccc ctc act 720 Asp Phe Ala Thr
Tyr Tyr Cys Leu Gln Asp Ser Asp Tyr Pro Leu Thr 225 230 235 240 ttc
ggc gga ggg acc aag ctg gag atc aaa cgt 753 Phe Gly Gly Gly Thr Lys
Leu Glu Ile Lys Arg 245 250 <210> SEQ ID NO 70 <211>
LENGTH: 765 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(765) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0103 scFv protein <400> SEQUENCE: 70 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga cat tat cag agt ggt ggc
tat gtc tac att acc ttc tat tac 336 Ala Arg His Tyr Gln Ser Gly Gly
Tyr Val Tyr Ile Thr Phe Tyr Tyr 100 105 110 cct atg gac gtc tgg ggc
cag ggc acc ctg gtc acc gtc tcg agt gga 384 Pro Met Asp Val Trp Gly
Gln Gly Thr Leu Val Thr Val Ser Ser Gly 115 120 125 ggc ggc ggt tca
ggc gga ggt ggc tct ggc ggt ggc gga agt gca ctt 432 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu 130 135 140 aat ttt
atg ctg act cag ccc cac tct gtg tcg gag tct ccg ggt aag 480 Asn Phe
Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 145 150 155
160 aca gta act ctc tcc tgc acc cgc tcc agt ggc agc att tca ttc gac
528 Thr Val Thr Leu Ser Cys Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp
165 170 175 tat gtg cag tgg tat caa cag cgg ccg ggc agc tcc ccc att
ctt gtg 576 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile
Leu Val 180 185 190 atc ttt gaa gat gac caa aga ccc tct ggg gtc cct
gat cga ttc tct 624 Ile Phe Glu Asp Asp Gln Arg Pro Ser Gly Val Pro
Asp Arg Phe Ser 195 200 205 ggc tcc atc gac agt acc tcc aac tct gcc
tcc ctc acc atc tct ggc 672 Gly Ser Ile Asp Ser Thr Ser Asn Ser Ala
Ser Leu Thr Ile Ser Gly 210 215 220 ctg cag agt gag gac gag ggt gac
tac tat tgt cag act tat gat gac 720 Leu Gln Ser Glu Asp Glu Gly Asp
Tyr Tyr Cys Gln Thr Tyr Asp Asp 225 230 235 240 aac cgt cag gtg ttc
ggc ggg ggg acc aag ctg acc gtc cta ggt 765 Asn Arg Gln Val Phe Gly
Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250 255 <210> SEQ ID
NO 71 <211> LENGTH: 744 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(744) <223> OTHER
INFORMATION: Polynucleotide encoding RGB0104 scFv protein
<400> SEQUENCE: 71 gag gtg cag ctg ttg gag tct ggg gga gac
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Asp
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga gag gac aga atg aga act cag ctt gac tcc tgg ggc cgg
ggc 336 Ala Arg Glu Asp Arg Met Arg Thr Gln Leu Asp Ser Trp Gly Arg
Gly 100 105 110 acc ctg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc
gga ggt ggc 384 Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 115 120 125 tct ggc ggt ggc gga agt gca cag tct gtg ttg
acg cag ccg ccc tca 432 Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu
Thr Gln Pro Pro Ser 130 135 140 gtg tct ggg gcc cca ggg cag agg gtc
acc atc tcc tgc act ggg agc 480 Val Ser Gly Ala Pro Gly Gln Arg Val
Thr Ile Ser Cys Thr Gly Ser 145 150 155 160 agc tcc aac atc ggg gcg
gat tat gat gta cac tgg tac caa cac cat 528 Ser Ser Asn Ile Gly Ala
Asp Tyr Asp Val His Trp Tyr Gln His His 165 170 175 cca gga aca gcc
ccc aga ctc ctc ata tat gat aac acc aat cgg ccc 576 Pro Gly Thr Ala
Pro Arg Leu Leu Ile Tyr Asp Asn Thr Asn Arg Pro 180 185 190 tca ggg
gtc cct gac cga ttc tct ggc tcc aag tct ggc acc tca gcc 624 Ser Gly
Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala 195 200 205
tcc ctg acc atc act ggg ctc cag gct gag gat gag gct gat tat tac 672
Ser Leu Thr Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 210
215 220 tgc cag tcc tat gac gcc agt ctg agt ggt tat gtg gtc ttc ggc
gga 720 Cys Gln Ser Tyr Asp Ala Ser Leu Ser Gly Tyr Val Val Phe Gly
Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt 744 Gly Thr Lys
Leu Thr Val Leu Gly 245 <210> SEQ ID NO 72 <211>
LENGTH: 744 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(744) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0106 scFv protein <400> SEQUENCE: 72 aag gtg cag
ctg gtg cag tct ggg gct gag gtg aag aag cct ggg tcg 48 Lys Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 tcg
gtg agg gtc tcc tgc aag gtc tct gga gac acc tcc acc tcc tat 96 Ser
Val Arg Val Ser Cys Lys Val Ser Gly Asp Thr Ser Thr Ser Tyr 20 25
30 att atc aac tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg
144 Ile Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45 gga gtg atc atc cct atg ttt ggt aca aca aat tac gca cag
aag ttc 192 Gly Val Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln
Lys Phe 50 55 60 gaa gac aga gtc acg att agc gcg gac gga tcc acg
agc aca gtg tac 240 Glu Asp Arg Val Thr Ile Ser Ala Asp Gly Ser Thr
Ser Thr Val Tyr 65 70 75 80 atg gaa ttg agt ggc ctg aaa tcc gag gac
acg gcc gta tat tac tgt 288 Met Glu Leu Ser Gly Leu Lys Ser Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg gga tcc gat ttt tgg agt ggt
tat gat ggc gag ccc gac gtc ttt 336 Ala Gly Ser Asp Phe Trp Ser Gly
Tyr Asp Gly Glu Pro Asp Val Phe 100 105 110 gat ctc tgg ggc caa gga
acc ctg gtc acc gtc tcc tca ggc gga ggc 384 Asp Leu Trp Gly Gln Gly
Thr Leu Val Thr Val Ser Ser Gly Gly Gly 115 120 125 ggt tca ggc gga
ggt ggc agc ggc ggt ggt gga tcg tct gag ctg act 432 Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr 130 135 140 cag gac
cct gct gtg tct gtg gcc ttg gga cag aca gtc agg atc act 480 Gln Asp
Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr 145 150 155
160 tgc caa gga gac agt ctc aga agc tat tac aca aac tgg ttc cag cag
528 Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gln Gln
165 170 175 aag cca gga cag gcc cct cta ctt gtc gtc tat gct aaa aat
aag cgg 576 Lys Pro Gly Gln Ala Pro Leu Leu Val Val Tyr Ala Lys Asn
Lys Arg 180 185 190 ccc tca ggg atc cca gac cga ttc tct ggc tcc agc
tca gga aac aca 624 Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser
Ser Gly Asn Thr 195 200 205 gct tcc ttg acc atc act ggg gct cag gcg
gaa gat gag gct gac tat 672 Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala
Glu Asp Glu Ala Asp Tyr 210 215 220 tac tgt cat tcc cgg gac agc agt
ggt aac cat gtg ctt ttc ggc gga 720 Tyr Cys His Ser Arg Asp Ser Ser
Gly Asn His Val Leu Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc
gtc cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ
ID NO 73 <211> LENGTH: 729 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(729) <223> OTHER
INFORMATION: Polynucleotide encoding RGB0110 scFv protein
<400> SEQUENCE: 73 gag gtg cag ctg gtg cag tct ggg gga ggc
gtg gtc cag cct ggg agg 48 Glu Val Gln Leu Val Gln Ser Gly Gly Gly
Val Val Gln Pro Gly Arg 1 5 10 15 tcc ctg aga ctc tcc tgc gca gcc
tct gga ttc acc ttc agt agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 ggc atg cac tgg gtc cgc
cag gct cca ggc aag ggg ctg gag tgg gtg 144 Gly Met His Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 gca gtt ata tca
tat gat gga agt aat aaa tac tat gca gac tcc gtg 192 Ala Val Ile Ser
Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cga ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gct gag gac acg gct gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aaa gcc tcc acg tat tac gat ttt tgg ttt gat atc tgg ggc
cag 336 Ala Lys Ala Ser Thr Tyr Tyr Asp Phe Trp Phe Asp Ile Trp Gly
Gln 100 105 110 ggg aca atg gtc act gtc tct tca ggt gga ggc ggt tca
ggc gga ggt 384 Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly 115 120 125 ggc agc ggc ggt ggc gga tcg gac atc cag atg
acc cag tct cca tcc 432 Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met
Thr Gln Ser Pro Ser 130 135 140 ttc ctg tct gca tct gta gga gac aga
gtc acc atc act tgc cgg gcc 480 Phe Leu Ser Ala Ser Val Gly Asp Arg
Val Thr Ile Thr Cys Arg Ala 145 150 155 160 agt cag ggc att aac aat
tat tta gcc tgg tat cag caa aaa cca ggg 528 Ser Gln Gly Ile Asn Asn
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 165 170 175 aga gcc cct aag
ctc ctg atc tac gct gca tcc agt tta caa agt ggg 576 Arg Ala Pro Lys
Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 180 185 190 gtc cca
tca agg ttc agc ggc agt gga tct ggc aca gat ttc act ctc 624 Val Pro
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 195 200 205
acc atc agc agc ctg cag cct gaa gat ttt gca act tat tac tgt ctc 672
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 210
215 220 caa gat tcc gat tat ccc ctc act ttc ggc gga ggg acc aag ctg
gag 720 Gln Asp Ser Asp Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu
Glu 225 230 235 240 atc aaa cgt 729 Ile Lys Arg <210> SEQ ID
NO 74 <211> LENGTH: 744 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(744) <223> OTHER
INFORMATION: Polynucleotide encoding RGB0113 scFv protein
<400> SEQUENCE: 74 ggg gtc cag ctg gtg cag tct ggg gct gag
ggg aag aag cct ggg gcc 48 Gly Val Gln Leu Val Gln Ser Gly Ala Glu
Gly Lys Lys Pro Gly Ala 1 5 10 15 tca gtg aag gtc tcc tgc aag gct
tct ggg ggc aac atc agc agg ttt 96 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Gly Asn Ile Ser Arg Phe 20 25 30 ggt atc aac tgg gtg cga
cag gcc cct gga caa ggg ctt gag tgg atg 144 Gly Ile Asn Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga gtg atc atc
cct atg ttt ggt aca aca aat tac gca cag aag ttc 192 Gly Val Ile Ile
Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 gaa gac
aga gtc acg att agc gcg gac gga tcc acg agc aca gtg tac 240 Glu Asp
Arg Val Thr Ile Ser Ala Asp Gly Ser Thr Ser Thr Val Tyr 65 70 75 80
atg gaa ttg agt ggc ctg aaa tcc gag gac acg gcc gta tat tac tgt 288
Met Glu Leu Ser Gly Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg gga tcc gat ttt tgg agt ggt tat gat ggc gag ccc gac gtc
ttt 336 Ala Gly Ser Asp Phe Trp Ser Gly Tyr Asp Gly Glu Pro Asp Val
Phe 100 105 110 gat ctc tgg ggc cgg gga acc ctg gtc acc gtc tct tca
ggt gga ggc 384 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
Gly Gly Gly 115 120 125 ggt tca ggc gga ggt ggc agc ggc ggt ggc gga
tcg tct gag ctg act 432 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ser Glu Leu Thr 130 135 140 cag gac cct gct gtg tct gtg gcc ttg
gga cag aca gtc agg atc act 480 Gln Asp Pro Ala Val Ser Val Ala Leu
Gly Gln Thr Val Arg Ile Thr 145 150 155 160 tgc caa gga gac agt ctc
aga agc tat tac aca aac tgg ttc cag cag 528 Cys Gln Gly Asp Ser Leu
Arg Ser Tyr Tyr Thr Asn Trp Phe Gln Gln 165 170 175 aag cca gga cag
gcc cct cta ctt gtc gtc tat gct aaa aat aag cgg 576 Lys Pro Gly Gln
Ala Pro Leu Leu Val Val Tyr Ala Lys Asn Lys Arg 180 185 190 ccc tca
gag atc cca gac cga ttc tct ggc tcc agc tca gga aac aca 624 Pro Ser
Glu Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 195 200 205
gct tcc ttg acc atc act ggg gct cag gcg gaa gat gag gct gac tat 672
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr 210
215 220 tac tgt cat tcc cgg gac agc agt ggt aac cat gtg ctt ttc ggc
gga 720 Tyr Cys His Ser Arg Asp Ser Ser Gly Asn His Val Leu Phe Gly
Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt 744 Gly Thr Lys
Leu Thr Val Leu Gly 245 <210> SEQ ID NO 75 <400>
SEQUENCE: 75 000 <210> SEQ ID NO 76 <211> LENGTH: 747
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(747) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0115 scFv protein <400> SEQUENCE: 76 cag ctg cag
ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg 48 Gln Leu Gln
Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 1 5 10 15 acc
ctg tcc ctc aac tgc gct gta tct ggt gac tcc atc agc agt gga 96 Thr
Leu Ser Leu Asn Cys Ala Val Ser Gly Asp Ser Ile Ser Ser Gly 20 25
30 aat tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gaa tgg
144 Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45 act gga gaa atc tat cat agt ggg acc gcc aac tac aac ccg
tcc ctc 192 Thr Gly Glu Ile Tyr His Ser Gly Thr Ala Asn Tyr Asn Pro
Ser Leu 50 55 60 aag agt cga gtc acc gtg tca gtg gac aag tcc acg
aac cag ttt tcc 240 Lys Ser Arg Val Thr Val Ser Val Asp Lys Ser Thr
Asn Gln Phe Ser 65 70 75 80 ctg aga atg agc tct gtg acc gcc gcg gac
acg gcc gtt tat tac tgt 288 Leu Arg Met Ser Ser Val Thr Ala Ala Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg agg gcc ggc tac tat gat gtg
gga ctc cca ttc gac tac tgg ggc 336 Ala Arg Ala Gly Tyr Tyr Asp Val
Gly Leu Pro Phe Asp Tyr Trp Gly 100 105 110 aaa gga acc ctg gtc acc
gtc tcg agt gga ggc ggc ggt tca ggc gga 384 Lys Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 ggt ggc tct ggc
ggt ggc gga agt gca cag gct gtg ctg act cag ccg 432 Gly Gly Ser Gly
Gly Gly Gly Ser Ala Gln Ala Val Leu Thr Gln Pro 130 135 140 tcc tca
gta tct ggg gcc cca ggg cag agg gtc acc ctc tcc tgc act 480 Ser Ser
Val Ser Gly Ala Pro Gly Gln Arg Val Thr Leu Ser Cys Thr 145 150 155
160 ggg agc agc tcc aac atc ggg gca ggt tct gag ttc cac tgg tac cag
528 Gly Ser Ser Ser Asn Ile Gly Ala Gly Ser Glu Phe His Trp Tyr Gln
165 170 175 cag gtt cca gga aca gcc ccc aag ctc ctc atc ttt ggt aac
acc aat 576 Gln Val Pro Gly Thr Ala Pro Lys Leu Leu Ile Phe Gly Asn
Thr Asn 180 185 190 cgg ccc tgg gga gtc cct gac cga ttc tct ggc tcc
aag tct ggc acc 624 Arg Pro Trp Gly Val Pro Asp Arg Phe Ser Gly Ser
Lys Ser Gly Thr 195 200 205 tca gcc tcc ctg gcc atc act ggg ctc cag
gct gag gat gag gct gat 672 Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln
Ala Glu Asp Glu Ala Asp 210 215 220 tat tat tgc cag tcc tat gac agc
agc ctg agt gct tat gtc ttc gga 720 Tyr Tyr Cys Gln Ser Tyr Asp Ser
Ser Leu Ser Ala Tyr Val Phe Gly 225 230 235 240 act ggg acc aag gtc
acc gtc cta ggt 747 Thr Gly Thr Lys Val Thr Val Leu Gly 245
<210> SEQ ID NO 77 <211> LENGTH: 741 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(741)
<223> OTHER INFORMATION: Polynucleotide encoding RGB0118 scFv
protein <400> SEQUENCE: 77 gag gtc cag ctg gtg cag tct ggg
gct gag gtg aag aag cct ggg gcc 48 Glu Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 tca gtg aag gtc tcc tgc
aag gct tct gga tac acc ttc acc gac tac 96 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 tat atg cac tgg
gtg cga cag gcc cct gga caa ggg ctt gag tgg atg 144 Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga tgg
atc aac cct aac agt ggt ggc aca aac tat gca cag aag ttt 192 Gly Trp
Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60
cag ggc agg gtc acc atg acc agg gac acg tcc atc agc aca gcc tac 240
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65
70 75 80 atg gag ctg agc agg ctg aga tct gac gac acg gcc gtg tat
ttc tgt 288 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr
Phe Cys 85 90 95 gcg aga gat ctt ctc tct tat ttc tat gat agt agt
ggt tac ctc gac 336 Ala Arg Asp Leu Leu Ser Tyr Phe Tyr Asp Ser Ser
Gly Tyr Leu Asp 100 105 110 aac tgg ggc caa ggg aca atg gtc acc gtc
tcg agt ggt gga ggc ggt 384 Asn Trp Gly Gln Gly Thr Met Val Thr Val
Ser Ser Gly Gly Gly Gly 115 120 125 tca ggc gga ggt ggc agc ggc ggt
ggc gga tcg tct gag ctg act cag 432 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ser Glu Leu Thr Gln 130 135 140 gac act gct gtg tct gtg
gcc ttg gga cag aca gtc agg atc act tgc 480 Asp Thr Ala Val Ser Val
Ala Leu Gly Gln Thr Val Arg Ile Thr Cys 145 150 155 160 caa gga gac
agt ctc aga agc tat tac aca aac tgg ttc cag cag aag 528 Gln Gly Asp
Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gln Gln Lys 165 170 175 cca
gga cag gcc cct cta ctt gtc gtc tat gct aaa aat aag cgg ccc 576 Pro
Gly Gln Ala Pro Leu Leu Val Val Tyr Ala Lys Asn Lys Arg Pro 180 185
190 tca ggg atc cca gac cga ttc tct ggc tcc agc tca gga aac aca gct
624 Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala
195 200 205 tcc ttg acc atc act ggg gct cag gcg gaa gat gag gct gac
tat tac 672 Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp
Tyr Tyr 210 215 220 tgt aac tcc cgg gac agc agt ggt aac cat gtg gta
ttc ggc gga ggg 720 Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val
Phe Gly Gly Gly 225 230 235 240 acc aag ctg acc gtc cta ggt 741 Thr
Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 78 <211>
LENGTH: 744 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(744) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0128 scFv protein <400> SEQUENCE: 78 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gca aga gag gat cct tgg agt gac
gct ttt gat ttg tgg ggc cgg gga 336 Ala Arg Glu Asp Pro Trp Ser Asp
Ala Phe Asp Leu Trp Gly Arg Gly 100 105 110 acc ctg gtc acc gtc tcg
agt gga ggc ggc ggt tca ggc gga ggt ggc 384 Thr Leu Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc
gga agt gca ctt aat ttt atg ctg act cag ccc cac 432 Ser Gly Gly Gly
Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 130 135 140 tct gtg
tcg gag tct ccg ggg aag acg gta acc att tcc tgc acc ggc 480 Ser Val
Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 145 150 155
160 agc agt ggc agc att gcc agc aac tat gtg cag tgg tac cag cag cgc
528 Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg
165 170 175 ccg ggc agt gcc ccc gcc act gtg atc tat gag gat aac caa
aga ccc 576 Pro Gly Ser Ala Pro Ala Thr Val Ile Tyr Glu Asp Asn Gln
Arg Pro 180 185 190 tct ggg gtc cct gat cgg ttc tct ggc tcc atc gac
agc tcc tcc aac 624 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp
Ser Ser Ser Asn 195 200 205 tct gcc tcc ctc acc atc tct gac ctg aag
act gag gac gag gct gac 672 Ser Ala Ser Leu Thr Ile Ser Asp Leu Lys
Thr Glu Asp Glu Ala Asp 210 215 220 tac tac tgt cag tct ttt gat aac
agc aaa tat gtg gta ttc ggc gga 720 Tyr Tyr Cys Gln Ser Phe Asp Asn
Ser Lys Tyr Val Val Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc
gtc cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ
ID NO 79 <211> LENGTH: 756 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(756) <223> OTHER
INFORMATION: Polynucleotide encoding RGB0129 scFv protein
<400> SEQUENCE: 79 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aaa ggg cct gat tgt act aat ggt gta tgc tat ctc ccc ttt
gac 336 Ala Lys Gly Pro Asp Cys Thr Asn Gly Val Cys Tyr Leu Pro Phe
Asp 100 105 110 tac tgg ggc agg ggc acc ctg gtc acc gtc tcg agt gga
ggc ggc ggt 384 Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly
Gly Gly Gly 115 120 125 tca ggc gga ggt ggc tct ggc ggt ggc gga agt
gca ctt aat ttt atg 432 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Leu Asn Phe Met 130 135 140 ctg act cag ccc cac tct gtg tcg gag
tct ccg ggt aag aca gta act 480 Leu Thr Gln Pro His Ser Val Ser Glu
Ser Pro Gly Lys Thr Val Thr 145 150 155 160 ctc tcc tgc acc cgc tcc
agt ggc agc att tca ttc gac tat gtg cag 528 Leu Ser Cys Thr Arg Ser
Ser Gly Ser Ile Ser Phe Asp Tyr Val Gln 165 170 175 tgg tat caa cag
cgg ccg ggc agc tcc ccc att ctt gtg atc ttt gaa 576 Trp Tyr Gln Gln
Arg Pro Gly Ser Ser Pro Ile Leu Val Ile Phe Glu 180 185 190 gat gac
caa aga ccc tct ggg gtc cct gat cga ttc tct ggc tcc atc 624 Asp Asp
Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile 195 200 205
gac agt acc tcc aac tct gcc tcc ctc acc atc tct ggc ctg cag agt 672
Asp Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln Ser 210
215 220 gag gac gag ggt gac tac tat tgt cag act tat gat gac aac cgt
cag 720 Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp Asp Asn Arg
Gln 225 230 235 240 gtg ttc ggc ggg ggg acc aag ctg acc gtc cta ggt
756 Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250
<210> SEQ ID NO 80 <211> LENGTH: 738 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(738)
<223> OTHER INFORMATION: Polynucleotide encoding RGB0137 scFv
protein <400> SEQUENCE: 80 gag gtg cag ctg gtg cag tct ggg
gct gag gtg gag aag cct ggg gcc 48 Glu Val Gln Leu Val Gln Ser Gly
Ala Glu Val Glu Lys Pro Gly Ala 1 5 10 15 tca gtg aaa gtc tcc tgc
aag gtt tct ggc tac acc ttc acc ggc gac 96 Ser Val Lys Val Ser Cys
Lys Val Ser Gly Tyr Thr Phe Thr Gly Asp 20 25 30 tat atg cac tgg
gtg cga cag gcc cct gga caa gga ctt gag tgg atg 144 Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga agg
atc gac cct aag tat ggt gac aca aac tat gca cag aag ttt 192 Gly Arg
Ile Asp Pro Lys Tyr Gly Asp Thr Asn Tyr Ala Gln Lys Phe 50 55 60
cag ggc agg gtc acc atg acc agg gac acg tcc atc agc aca gtc tac 240
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 65
70 75 80 atg gag ctg agc agg ctg aga tct gac gac acg gcc cta tat
ttc tgt 288 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Leu Tyr
Phe Cys 85 90 95 gcg aca gat aac agt ggg tta tat gat gct ttt gac
aag tgg ggg aaa 336 Ala Thr Asp Asn Ser Gly Leu Tyr Asp Ala Phe Asp
Lys Trp Gly Lys 100 105 110 ggg acc acg gtc acc gtc tcg agt ggt gga
ggc ggt tca ggc gga ggt 384 Gly Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 ggc agc ggc ggt ggc gga tcg cag
tct gtg ctg act cag cct gcc tcc 432 Gly Ser Gly Gly Gly Gly Ser Gln
Ser Val Leu Thr Gln Pro Ala Ser 130 135 140 gtg tct ggg tct cct gga
cag tcg atc acc atc tcc tgc act gga acc 480 Val Ser Gly Ser Pro Gly
Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr 145 150 155 160 agc agt gac
gtt ggt ggt tat aac tat gtc tcc tgg tac caa caa cac 528 Ser Ser Asp
Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His 165 170 175 cca
ggc aaa gcc ccc aaa ctc atg att tat gag ggc agt aag cgg ccc 576 Pro
Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Gly Ser Lys Arg Pro 180 185
190 tca ggg gtt tct aat cgc ttc tct ggc tcc aag tct ggc aac acg gcc
624 Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala
195 200 205 tcc ctg aca atc tct agg ctc cag gct gag gac gag gct gat
tat tac 672 Ser Leu Thr Ile Ser Arg Leu Gln Ala Glu Asp Glu Ala Asp
Tyr Tyr 210 215 220 tgc agc tca tat aca acc agg agc act cga gtt ttc
ggc gga ggg acc 720 Cys Ser Ser Tyr Thr Thr Arg Ser Thr Arg Val Phe
Gly Gly Gly Thr 225 230 235 240 aag ctg acc gtc cta ggt 738 Lys Leu
Thr Val Leu Gly 245 <210> SEQ ID NO 81 <211> LENGTH:
747 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(747) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0146 scFv protein <400> SEQUENCE: 81 cag gta cag
ctg cag cag tca ggc cca aga cta gtg aag cct tca cag 48 Gln Val Gln
Leu Gln Gln Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 1 5 10 15 acc
ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc aga ggg 96 Thr
Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Arg Gly 20 25
30 ggt tac tac tgg agc tgg atc cgc cag ctc cca ggg aag ggc ctg gag
144 Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu Glu
35 40 45 tgg att ggg tac atc tat cac agt ggg agc acc tac tac aac
ccg ccc 192 Trp Ile Gly Tyr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn
Pro Pro 50 55 60 ctc aag agt cga gtt acc atg tca gta gac acg tct
aag aat cag ttc 240 Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser
Lys Asn Gln Phe 65 70 75 80 tcc ctg aac ctg agc tct gtg act gcc gcg
gac acg gcc gtt tat tac 288 Ser Leu Asn Leu Ser Ser Val Thr Ala Ala
Asp Thr Ala Val Tyr Tyr 85 90 95 tgt gcg aga gaa aag ggc ggc gac
tgg gag caa ctg gtc ttt gac cac 336 Cys Ala Arg Glu Lys Gly Gly Asp
Trp Glu Gln Leu Val Phe Asp His 100 105 110 tgg ggc aga ggg aca atg
gtc acc gtc tct tca ggt gga ggc ggt tca 384 Trp Gly Arg Gly Thr Met
Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 ggc gga ggt ggc
agc ggc ggt ggc gga tcg cag tct gtg ttg acg cag 432 Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln 130 135 140 ccg ccc
tca gtg tct gcg gcc cca gga cag aag gtc acc att tcc tgc 480 Pro Pro
Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile Ser Cys 145 150 155
160 tct gga agc acc tcc aac att ggg aat aat tat gtc tcc tgg tac caa
528 Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp Tyr Gln
165 170 175 cag cac cca ggc aaa gcc ccc aaa ctc atg att tat gat gtc
agt aag 576 Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val
Ser Lys 180 185 190 cgg ccc tca ggg gtc cct gac cga ttc tct ggc tcc
aag tct ggc aac 624 Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser
Lys Ser Gly Asn 195 200 205 tca gcc tcc ctg gac atc agt ggg ctc cag
tct gag gat gag gct gat 672 Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln
Ser Glu Asp Glu Ala Asp 210 215 220 tat tac tgt gca gca tgg gat gac
agc ctg agt gaa ttt ctc ttc gga 720 Tyr Tyr Cys Ala Ala Trp Asp Asp
Ser Leu Ser Glu Phe Leu Phe Gly 225 230 235 240 act ggg acc aag ctg
acc gtc cta ggt 747 Thr Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 82 <211> LENGTH: 747 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(747)
<223> OTHER INFORMATION: Polynucleotide encoding RGB0153 scFv
protein <400> SEQUENCE: 82 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga ggt gcg gga gct act cca ttt aat gct ttt
gat atc tgg ggg 336 Ala Arg Gly Ala Gly Ala Thr Pro Phe Asn Ala Phe
Asp Ile Trp Gly 100 105 110 cgg ggg acc acg gtc acc gtc tcg agt gga
ggc ggc ggt tca ggc gga 384 Arg Gly Thr Thr Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly 115 120 125 ggt ggc tct ggc ggt ggc gga agt
gca ctt aat ttt atg ctg act cag 432 Gly Gly Ser Gly Gly Gly Gly Ser
Ala Leu Asn Phe Met Leu Thr Gln 130 135 140 ccc cac tct gtg tcg gag
tct ccg ggt aag aca gta act ctc tcc tgc 480 Pro His Ser Val Ser Glu
Ser Pro Gly Lys Thr Val Thr Leu Ser Cys 145 150 155 160 acc cgc tcc
agt ggc agt att tca ttc gac tat gtg cag tgg tat caa 528 Thr Arg Ser
Ser Gly Ser Ile Ser Phe Asp Tyr Val Gln Trp Tyr Gln 165 170 175 cag
cgg ccg ggc agc tcc ccc att ctt gtg atc ttt gaa gat gac caa 576 Gln
Arg Pro Gly Ser Ser Pro Ile Leu Val Ile Phe Glu Asp Asp Gln 180 185
190 aga ccc tct ggg gtc cct gat cga ttc tct ggc tcc atc gac agt acc
624 Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Thr
195 200 205 tcc aac tct gcc tcc ctc acc atc tct ggc ctg cag agt gag
gac gag 672 Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu
Asp Glu 210 215 220 ggt gac tac tat tgt cag act tat gat gac aac cgt
cag gtg ttc ggc 720 Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp Asp Asn Arg
Gln Val Phe Gly 225 230 235 240 ggg ggg acc aag gtc acc gtc cta ggt
747 Gly Gly Thr Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO
83 <211> LENGTH: 741 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(741) <223> OTHER
INFORMATION: Polynucleotide encoding RGB0163 scFv protein
<400> SEQUENCE: 83 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aca gat cct tac tat gat agt agt ggt tat tac ccc ttt agc
tac 336 Ala Thr Asp Pro Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro Phe Ser
Tyr 100 105 110 tgg ggg cgg ggg acc acg gtc acc gtc tcg agt gga ggc
ggc ggt tca 384 Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Gly Ser 115 120 125 ggc gga ggt ggc tct ggc ggt ggc gga agt gca
cag tct gtg ctg acg 432 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
Gln Ser Val Leu Thr 130 135 140 cag ccg ccc tca gtg tca gtg gcc cca
gga aag acg gcc aca att acc 480 Gln Pro Pro Ser Val Ser Val Ala Pro
Gly Lys Thr Ala Thr Ile Thr 145 150 155 160 tgt ggg gga gac ttt gca
act aaa aat gtg aat tgg tac caa cgg aag 528 Cys Gly Gly Asp Phe Ala
Thr Lys Asn Val Asn Trp Tyr Gln Arg Lys 165 170 175 ccg ggc cag gcc
cct gtg acg gtc atc tat tat gac acc gag cgg ccc 576 Pro Gly Gln Ala
Pro Val Thr Val Ile Tyr Tyr Asp Thr Glu Arg Pro 180 185 190 tca gcg
atc cct gag cgc ttc tct ggc tcc aac act ggg tcc acg gcc 624 Ser Ala
Ile Pro Glu Arg Phe Ser Gly Ser Asn Thr Gly Ser Thr Ala 195 200 205
acc ctg acc atc agc agg gtc gaa gcc ggg gat gag gcc gac tat tat 672
Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 210
215 220 tgt cag gtg tgg gat agt ttt act gat cat cgg ctg ttc ggc gga
ggg 720 Cys Gln Val Trp Asp Ser Phe Thr Asp His Arg Leu Phe Gly Gly
Gly 225 230 235 240 acc aag ctg acc gtc cta ggt 741 Thr Lys Leu Thr
Val Leu Gly 245 <210> SEQ ID NO 84 <211> LENGTH: 759
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(759) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0165 scFv protein <400> SEQUENCE: 84 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg gga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg acg ggg ggt agt ggt tcc ccc
gta tac tac tat tac cac tac ttg 336 Ala Thr Gly Gly Ser Gly Ser Pro
Val Tyr Tyr Tyr Tyr His Tyr Leu 100 105 110 gac gtc tgg ggc cga ggc
acc ctg gtc acc gtc tcg agt gga ggc ggc 384 Asp Val Trp Gly Arg Gly
Thr Leu Val Thr Val Ser Ser Gly Gly Gly 115 120 125 ggt tca ggc gga
ggt ggc tct ggc ggt ggc gga agt gca ctt aat ttt 432 Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe 130 135 140 atg ctg
act cag ccc cac tct gtg tcg gag tct ccg ggt aag aca gta 480 Met Leu
Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val 145 150 155
160 act ctc tcc tgc acc cgc tcc agt ggc agc att tca ttc gac tat gtg
528 Thr Leu Ser Cys Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp Tyr Val
165 170 175 cag tgg tat caa cag cgg ccg ggc agc tcc ccc att ctt gtg
atc ttt 576 Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu Val
Ile Phe 180 185 190 gaa gat gac caa aga ccc tct ggg gtc cct gat cga
ttc tct ggc tcc 624 Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg
Phe Ser Gly Ser 195 200 205 atc gac agt acc tcc aac tct gcc tcc ctc
acc atc tct ggc ctg cag 672 Ile Asp Ser Thr Ser Asn Ser Ala Ser Leu
Thr Ile Ser Gly Leu Gln 210 215 220 agt gag gac gag ggt gac tac tat
tgt cag act tat gat gac aac cgt 720 Ser Glu Asp Glu Gly Asp Tyr Tyr
Cys Gln Thr Tyr Asp Asp Asn Arg 225 230 235 240 cag gtg ttc ggc ggg
ggg acc aag ctg acc gtc cta ggt 759 Gln Val Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu Gly 245 250 <210> SEQ ID NO 85 <211>
LENGTH: 744 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(744) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0174 scFv protein <400> SEQUENCE: 85 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg agt gac tct gat agt agt gat
tat tac tat ttt gac tct tgg ggc 336 Ala Ser Asp Ser Asp Ser Ser Asp
Tyr Tyr Tyr Phe Asp Ser Trp Gly 100 105 110 cag ggg aca atg gtc acc
gtc tcg agt gga ggc ggc ggt tca ggc gga 384 Gln Gly Thr Met Val Thr
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 ggt ggc tct ggc
ggt ggc gga agt gca cag tct gtg ctg act cag cca 432 Gly Gly Ser Gly
Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro 130 135 140 ccc tca
gcg tct ggg acc ccc ggg cag agg gtc acc atc tct tgt tct 480 Pro Ser
Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 145 150 155
160 gga agc agc tcc aat atc gga ttt aat gat gtg tac tgg tat cag cag
528 Gly Ser Ser Ser Asn Ile Gly Phe Asn Asp Val Tyr Trp Tyr Gln Gln
165 170 175 ctc cca gga ttg gcc ccc aaa ctc ctc atc tat agt aat aat
cag cgg 576 Leu Pro Gly Leu Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn
Gln Arg 180 185 190 ccc tca ggg gtc cct gac cga ttc tct ggc tcc gag
tct ggc acc tca 624 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Glu
Ser Gly Thr Ser 195 200 205 gcc tcc ctg gcc atc agt ggg ctc cgg tcc
gag gat gag gct gat tat 672 Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser
Glu Asp Glu Ala Asp Tyr 210 215 220 tac tgt gca aca tgg gat gac agc
ctg agt gcc ccg gtg ttc ggc gga 720 Tyr Cys Ala Thr Trp Asp Asp Ser
Leu Ser Ala Pro Val Phe Gly Gly 225 230 235 240 ggg acc aag gtc acc
gtc cta ggt 744 Gly Thr Lys Val Thr Val Leu Gly 245 <210> SEQ
ID NO 86 <211> LENGTH: 753 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(753) <223> OTHER
INFORMATION: Polynucleotide encoding RGB0185 scFv protein
<400> SEQUENCE: 86 cag gtg cag ctg gta cag tct ggg gct gag
gtg aag aag cct ggg gcc 48 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 tca gtg aag gtc tcc tgc aag gct
tct gga tac acc ttc acc gac tac 96 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 tat ata cac tgg gtg cga
cag gcc cct gga caa ggg ctt gag tgg atg 144 Tyr Ile His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga tgg atc aac
cct aaa agt ggt gac aca aac tat gca cag aag ttt 192 Gly Trp Ile Asn
Pro Lys Ser Gly Asp Thr Asn Tyr Ala Gln Lys Phe 50 55 60 cag ggc
agg gtc acc atg gcc agg gac acg tcc atg agc acg gcc tcc 240 Gln Gly
Arg Val Thr Met Ala Arg Asp Thr Ser Met Ser Thr Ala Ser 65 70 75 80
gtg gaa ctg aga agg ttg aca tct gac gac acg gcc gtg tat tac tgt 288
Val Glu Leu Arg Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg agg aac tcg ttc gac ttt ggg agt ggc tat ggg ctc ttc tac
cag 336 Ala Arg Asn Ser Phe Asp Phe Gly Ser Gly Tyr Gly Leu Phe Tyr
Gln 100 105 110 tac att atg gac gtc tgg ggc caa gga acc ctg gtc acc
gtc tcc tca 384 Tyr Ile Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser 115 120 125 ggt gga ggc ggt tca ggc gga ggt ggc agc ggc
ggt ggc gga tcg gac 432 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Asp 130 135 140 atc cag atg acc cag tct cca tcc ttc
ctg tct gca tct gta gga gac 480 Ile Gln Met Thr Gln Ser Pro Ser Phe
Leu Ser Ala Ser Val Gly Asp 145 150 155 160 aga gtc acc atc act tgc
cgg gcc agt cag ggc att aac aat tat tta 528 Arg Val Thr Ile Thr Cys
Arg Ala Ser Gln Gly Ile Asn Asn Tyr Leu 165 170 175 gcc tgg tat cag
caa aaa cca ggg aga gcc cct aag ctc ctg atc tac 576 Ala Trp Tyr Gln
Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr 180 185 190 gct gca
tcc agt tta caa agt ggg gtc cca tca agg ttc agc ggc agt 624 Ala Ala
Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 195 200 205
gga tct ggc aca gat ttc act ctc acc atc agc agc ctg cag cct gaa 672
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 210
215 220 gat ttt gca act tat tac tgt ctc caa gat tcc gat tat ccc ctc
act 720 Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Asp Tyr Pro Leu
Thr 225 230 235 240 ttc ggc gga ggg acc aag ctg acc gtc cta ggt 753
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250 <210> SEQ
ID NO 87 <211> LENGTH: 759 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(759) <223> OTHER
INFORMATION: Polynucleotide encoding RGB0187 scFv protein
<400> SEQUENCE: 87 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga gat tcg tgt ccg tat tgt agt acc aac agc ggc tcc ttt
gac 336 Ala Arg Asp Ser Cys Pro Tyr Cys Ser Thr Asn Ser Gly Ser Phe
Asp 100 105 110 tac tgg ggc caa ggg aca atg gtc acc gtc tcg agt gga
ggc ggc ggt 384 Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
Gly Gly Gly 115 120 125 tca ggc gga ggt ggc tct ggc ggt ggc gga agt
gca ctt aat ttt atg 432 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Leu Asn Phe Met 130 135 140 ctg act cag ccc cac tct gtg tcg gag
tct ccg ggg aag acg gtc acc 480 Leu Thr Gln Pro His Ser Val Ser Glu
Ser Pro Gly Lys Thr Val Thr 145 150 155 160 atc tcc tgc acc cgc acc
agt ggg aac att gcc ggc tac ttt gtg cag 528 Ile Ser Cys Thr Arg Thr
Ser Gly Asn Ile Ala Gly Tyr Phe Val Gln 165 170 175 tgg tac cag cag
cgc ccg ggc agt tcc ccc acc act gtg atc tat gag 576 Trp Tyr Gln Gln
Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu 180 185 190 gat tac
caa cga ccc tct ggg gtc cct gat cgg ttc tct ggc tcc atc 624 Asp Tyr
Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile 195 200 205
gac agg tcc tcc aac tct gcc tcc ctc acc atc tct gga ctg aag cct 672
Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Pro 210
215 220 gac gac gag gct gac tac tat tgt cag tct tat gat gac acc tct
caa 720 Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asp Thr Ser
Gln 225 230 235 240 ggt gtg ttc ggc gca ggg acc aag ctg acc gtc cta
ggt 759 Gly Val Phe Gly Ala Gly Thr Lys Leu Thr Val Leu Gly 245 250
<210> SEQ ID NO 88 <211> LENGTH: 744 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(744)
<223> OTHER INFORMATION: Polynucleotide encoding RGB0194 scFv
protein <400> SEQUENCE: 88 gag gtg cag ctg gtg gag tct ggg
gct gaa gtg aag aag cct ggg tcc 48 Glu Val Gln Leu Val Glu Ser Gly
Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 tcg gtg aag gtc tcc tgc
aag gct tct gga ggc acc ctc agc agg ttt 96 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Gly Thr Leu Ser Arg Phe 20 25 30 ggt atc aac tgg
gtg cga cag gcc cct gga caa ggg ctt gag tgg atg 144 Gly Ile Asn Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 ggg gtg
atc atc cct atg ttt ggt aca aca aat tac gca cag aag ttc 192 Gly Val
Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60
gaa gac aga gtc acg att agc gcg gac gga tcc acg agc aca gtg tac 240
Glu Asp Arg Val Thr Ile Ser Ala Asp Gly Ser Thr Ser Thr Val Tyr 65
70 75 80 atg gaa ttg agt ggc ctg aag tcc gag gac acg gcc gtt tat
tac tgt 288 Met Glu Leu Ser Gly Leu Lys Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg gga tca gat ttt tgg agt ggt tat gat ggc gag
ccc gac gtc ttt 336 Ala Gly Ser Asp Phe Trp Ser Gly Tyr Asp Gly Glu
Pro Asp Val Phe 100 105 110 gat ctc tgg ggc cga ggc acc ctg gtc acc
gtc tcg agt ggt gga ggc 384 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly 115 120 125 ggt tca ggc gga ggt ggc agc ggc
ggt ggc gga tcg tct gag ctg act 432 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser Glu Leu Thr 130 135 140 cag gac cct gct gcg tct
gtg gcc ttg gga cag aca gtc agg atc act 480 Gln Asp Pro Ala Ala Ser
Val Ala Leu Gly Gln Thr Val Arg Ile Thr 145 150 155 160 tgc caa gga
gac agt ctc aga agc tat tac aca aac tgg ttc cag cag 528 Cys Gln Gly
Asp Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gln Gln 165 170 175 aag
cca gga cag gcc cct cta ctt gtc gtc tat gct aaa aat aag cgg 576 Lys
Pro Gly Gln Ala Pro Leu Leu Val Val Tyr Ala Lys Asn Lys Arg 180 185
190 ccc tca ggg atc cca gac cga ttc tct ggc tcc agc tca ggg aac aca
624 Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr
195 200 205 gct tcc ttg acc atc act ggg gct cag gcg gaa gat gag gct
gac tat 672 Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala
Asp Tyr 210 215 220 tac tgt cat tcc cgg gac agc agt ggt aac cat gtg
ctt ttc ggc gga 720 Tyr Cys His Ser Arg Asp Ser Ser Gly Asn His Val
Leu Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt 744
Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 89
<211> LENGTH: 750 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(750) <223> OTHER INFORMATION:
Polynucleotide encoding RGC0102 scFv protein <400> SEQUENCE:
89 cag gtg cag ctg cag gag tcc ggc cca gga ctg gtg aag cct tcg ggg
48 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15 acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc
agt agt 96 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser
Ser Ser 20 25 30 aac tac tgg agt tgg gtc cgc cag ccc cca ggg aag
ggg ctg gag tgg 144 Asn Tyr Trp Ser Trp Val Arg Gln Pro Pro Gly Lys
Gly Leu Glu Trp 35 40 45 att ggg gag atc tat cat gat ggg agc acc
aac tac aac ccg tcc ctc 192 Ile Gly Glu Ile Tyr His Asp Gly Ser Thr
Asn Tyr Asn Pro Ser Leu 50 55 60 aag agt cga gtc acc atg tca gca
gac aag tcc aag aac cag ttc tcc 240 Lys Ser Arg Val Thr Met Ser Ala
Asp Lys Ser Lys Asn Gln Phe Ser 65 70 75 80 ctg aag ctg agc tct gtg
acc gcc gcg gac acg gcc gtg tat tac tgt 288 Leu Lys Leu Ser Ser Val
Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gat tcc
ccc tcg tat agc agt ggc tgg tac tct gac tac tgg 336 Ala Arg Asp Ser
Pro Ser Tyr Ser Ser Gly Trp Tyr Ser Asp Tyr Trp 100 105 110 ggc aga
ggc acc ctg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc 384 Gly Arg
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125
gga ggt ggc tct ggc ggt ggc gga agt gca cag tct gtg ctg act cag 432
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln 130
135 140 cca ccc tca gcg tct ggg acc ccc ggg cag agg gtc acc atc tct
tgt 480 Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser
Cys 145 150 155 160 tct gga agc agc tcc aac atc gga agt aat act gta
aac tgg tac cag 528 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val
Asn Trp Tyr Gln 165 170 175 caa ctc cca gga acg gcc ccc aaa ctc ctc
atc ttt agt aat aat cag 576 Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
Ile Phe Ser Asn Asn Gln 180 185 190 cgg ccc tca ggg gtc cct gac cga
ttc tct ggc tcc aag tct ggc acc 624 Arg Pro Ser Gly Val Pro Asp Arg
Phe Ser Gly Ser Lys Ser Gly Thr 195 200 205 tca gcc tcc ctg gcc atc
agt ggg ctc cag tct gag gat gag gct gtt 672 Ser Ala Ser Leu Ala Ile
Ser Gly Leu Gln Ser Glu Asp Glu Ala Val 210 215 220 tat tac tgt gca
gcg tgg gat gac agc ctg act ggt ttt tat gtc ttc 720 Tyr Tyr Cys Ala
Ala Trp Asp Asp Ser Leu Thr Gly Phe Tyr Val Phe 225 230 235 240 gga
gct ggg acc aag gtc acc gtc cta ggt 750 Gly Ala Gly Thr Lys Val Thr
Val Leu Gly 245 250 <210> SEQ ID NO 90 <211> LENGTH:
726 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(726) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0104 scFv protein <400> SEQUENCE: 90 gag gtg cag
ctg gtg cag tct ggg gct gag gtg agg aag cct ggg tcc 48 Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 1 5 10 15 tca
gtg aag gtc tcc tgc acg acc tct gaa aac acc ttt agg agg tct 96 Ser
Val Lys Val Ser Cys Thr Thr Ser Glu Asn Thr Phe Arg Arg Ser 20 25
30 agt ttc agt tgg cta cgc cag gcc cct gga caa ggt ctt gag tgg atg
144 Ser Phe Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45 gga agg atc atc cct atc att cat tct gaa acc tac gca cag
aac ttt 192 Gly Arg Ile Ile Pro Ile Ile His Ser Glu Thr Tyr Ala Gln
Asn Phe 50 55 60 cag ggc aga gtc acc atg acc gcg gac gaa tct acg
agt aca gtc tat 240 Gln Gly Arg Val Thr Met Thr Ala Asp Glu Ser Thr
Ser Thr Val Tyr 65 70 75 80 gtg gag gtg aga agc ctg aga tct gaa gac
acg gcc gtc tat tac tgt 288 Val Glu Val Arg Ser Leu Arg Ser Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gac tcc ccc ccc tac aat
gca gac ttt gat ttc tgg ggc aga 336 Ala Arg Asp Ser Pro Pro Tyr Asn
Ala Asp Phe Asp Phe Trp Gly Arg 100 105 110 ggc acc ctg gtc acc gtc
tcg agt gga ggc ggc ggt tca ggc gga ggt 384 Gly Thr Leu Val Thr Val
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 ggc tct ggc ggt
ggc gga agt gca cag tct gtg ctg act cag cca ccc 432 Gly Ser Gly Gly
Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro 130 135 140 tca gtg
tcc gtg tct cca gga cag aca gcc acc atc acc tgc tct gga 480 Ser Val
Ser Val Ser Pro Gly Gln Thr Ala Thr Ile Thr Cys Ser Gly 145 150 155
160 gac aaa ttg ggg gat aaa tat gct tcc tgg tat cag aag aag gca gga
528 Asp Lys Leu Gly Asp Lys Tyr Ala Ser Trp Tyr Gln Lys Lys Ala Gly
165 170 175 cag tcc cct gtg ctg gtc atc tat caa gat aac aag cgg ccg
tca ggg 576 Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro
Ser Gly 180 185 190 atc cct gag cga ttc tct ggc tcc aac tct ggg aac
aca gcc act ctg 624 Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn
Thr Ala Thr Leu 195 200 205 acc atc agc ggg acc cag gct atg gat gag
gct gac tat tac tgt cag 672 Thr Ile Ser Gly Thr Gln Ala Met Asp Glu
Ala Asp Tyr Tyr Cys Gln 210 215 220 gcg tgg gac agc agt gtg gtt ttc
ggc gga ggg acc aag gtc acg gtc 720 Ala Trp Asp Ser Ser Val Val Phe
Gly Gly Gly Thr Lys Val Thr Val 225 230 235 240 cta ggt 726 Leu Gly
<210> SEQ ID NO 91 <211> LENGTH: 738 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(738)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0107 scFv
protein <400> SEQUENCE: 91 cag gtg cag ctg cag gag tcg ggc
cca gga ctg gtg aag ccg tcg gag 48 Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 act ctg tcc ctc acc tgc
acc gtc tcc ggt gac tca ctt agt agg agt 96 Thr Leu Ser Leu Thr Cys
Thr Val Ser Gly Asp Ser Leu Ser Arg Ser 20 25 30 agt tac tac tgg
ggc tgg atc cgc cag ccc cca ggg aag ggg ctg gag 144 Ser Tyr Tyr Trp
Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 tgg att
gga agt gtc ttt tat agt ggg agc gcc gac tac aac ccg tcc 192 Trp Ile
Gly Ser Val Phe Tyr Ser Gly Ser Ala Asp Tyr Asn Pro Ser 50 55 60
ctc aag agt cgc gcc tcc ata tca gtg gac acg tac caa aac caa gtc 240
Leu Lys Ser Arg Ala Ser Ile Ser Val Asp Thr Tyr Gln Asn Gln Val 65
70 75 80 tcc ctg aag ttg acc tct gtg acc gcc gcg gac acg gcc gtg
tat tac 288 Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val
Tyr Tyr 85 90 95 tgt gcg agg gat gac ggg agc acc ttc gac ccc tgg
ggc cga gga acc 336 Cys Ala Arg Asp Asp Gly Ser Thr Phe Asp Pro Trp
Gly Arg Gly Thr 100 105 110 ctg gtc acc gtc tcg agt gga ggc ggc ggt
tca ggc gga ggt ggc tct 384 Leu Val Thr Val Ser Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser 115 120 125 ggc ggt ggc gga agt gca ctt tcc
tat gtg ctg act cag cca ccc tca 432 Gly Gly Gly Gly Ser Ala Leu Ser
Tyr Val Leu Thr Gln Pro Pro Ser 130 135 140 gcg tct gag acc ccc ggg
cag agg gtc acc atc tct tgt tct gga agc 480 Ala Ser Glu Thr Pro Gly
Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 145 150 155 160 agc gcc aac
atc gaa tat aat ttt gta tac tgg tac cag caa ctc cca 528 Ser Ala Asn
Ile Glu Tyr Asn Phe Val Tyr Trp Tyr Gln Gln Leu Pro 165 170 175 gga
acg gcc ccc aaa ctc ctc atc tat agg aat aat cag cgg ccc tca 576 Gly
Thr Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser 180 185
190 ggg gtc cct gat cga ttc tct ggc tcc aag tct ggc acc tca gcc tcc
624 Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser
195 200 205 ctg gcc atc agt ggg ctc cgg tcc gag gat gag gcc gat tat
tac tgt 672 Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr
Tyr Cys 210 215 220 gca gca tgg gat gac agt ctg aat ggt tat gtc ttc
gga act ggg acc 720 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe
Gly Thr Gly Thr 225 230 235 240 aag gtc acc gtc cta ggt 738 Lys Val
Thr Val Leu Gly 245 <210> SEQ ID NO 92 <211> LENGTH:
738 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(738) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0108 scFv protein <400> SEQUENCE: 92 cag gtg cag
ctg cag gag tcg ggc cca gga ctg gtg aag ccg tcg gag 48 Gln Val Gln
Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 acc
ctg tcc ctc acc tgc act gtc tct ggg gac tcc atc gac aag agt 96 Thr
Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Asp Lys Ser 20 25
30 tct tac tac tgg gcc tgg atc cgt cag ccc cca ggg aag ggc ctg gag
144 Ser Tyr Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45 tgg att gcg agt gtc ttt tac gat ggg acc gcc gac tac agt
ccg tcc 192 Trp Ile Ala Ser Val Phe Tyr Asp Gly Thr Ala Asp Tyr Ser
Pro Ser 50 55 60 ctc agg agt cga gtc tcc atg tcg gta gac agg tcc
cta aac cac gtc 240 Leu Arg Ser Arg Val Ser Met Ser Val Asp Arg Ser
Leu Asn His Val 65 70 75 80 tcc ctg agg ctg acc tct ctg acc gcc gcg
gac acg gcc act tat tac 288 Ser Leu Arg Leu Thr Ser Leu Thr Ala Ala
Asp Thr Ala Thr Tyr Tyr 85 90 95 tgt gcg aga gat gac ggg agt tcg
ttc gac ccc tgg ggc cga ggc acc 336 Cys Ala Arg Asp Asp Gly Ser Ser
Phe Asp Pro Trp Gly Arg Gly Thr 100 105 110 ctg gtc acc gtc tcg agt
gga ggc ggc ggt tca ggc gga ggt ggc tct 384 Leu Val Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 ggc ggt ggc gga
agt gca ctt tcc tat gtg ctg act cag cca ccc tca 432 Gly Gly Gly Gly
Ser Ala Leu Ser Tyr Val Leu Thr Gln Pro Pro Ser 130 135 140 gcg tct
ggg acc ccc ggg cag agg gtc acc atc tct tgt tct gga agc 480 Ala Ser
Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 145 150 155
160 agc tcc aac acc gga agt aat tat gta tac tgg tac cag cag ctc cca
528 Ser Ser Asn Thr Gly Ser Asn Tyr Val Tyr Trp Tyr Gln Gln Leu Pro
165 170 175 gga acg gcc ccc aaa ctc ctc atc tat agg aat aat cag cgg
ccc tca 576 Gly Thr Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln Arg
Pro Ser 180 185 190 ggg gtc cct gac cga ttc tct ggc tcc aag tct ggc
acc tca gcc tcc 624 Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly
Thr Ser Ala Ser 195 200 205 ctg gcc atc agt ggg ctc cgg tcc gag gat
gag gct gat tat tac tgt 672 Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp
Glu Ala Asp Tyr Tyr Cys 210 215 220 gca gca tgg gat gac agc ctg agt
ggt tat gtc ttc gga act ggg acc 720 Ala Ala Trp Asp Asp Ser Leu Ser
Gly Tyr Val Phe Gly Thr Gly Thr 225 230 235 240 aag gtc acc gtc cta
ggt 738 Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO 93
<211> LENGTH: 738 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(738) <223> OTHER INFORMATION:
Polynucleotide encoding RGC0110 scFv protein <400> SEQUENCE:
93 cag gtc cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc
48 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 tca gtg aag att tcc tgc aag gca tct gga tac acc ttc aac
aga tat 96 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn
Arg Tyr 20 25 30 tac atc cac tgg gtg cga cag gcc cct gga caa gga
ctt gag tgg gtg 144 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Val 35 40 45 gga att atc aac cct cgt gga gat agc gca
aat tac gca cag aag ttc 192 Gly Ile Ile Asn Pro Arg Gly Asp Ser Ala
Asn Tyr Ala Gln Lys Phe 50 55 60 cag ggc aga gtc acc ctg acc agg
gac acg tcc gcg cgc aca gtt tac 240 Gln Gly Arg Val Thr Leu Thr Arg
Asp Thr Ser Ala Arg Thr Val Tyr 65 70 75 80 atg gaa atg aac agc ctg
aga cct gac gac acg gcc gta tat tat tgt 288 Met Glu Met Asn Ser Leu
Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gag ggg
gtg gga gct act tgg gtc cac tgg ggc aaa gga acc 336 Ala Arg Glu Gly
Val Gly Ala Thr Trp Val His Trp Gly Lys Gly Thr 100 105 110 ctg gtc
acc gtc tcg agt gga ggc ggc ggt tca ggc gga ggt ggc tct 384 Leu Val
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125
ggc ggt ggc gga agt gca ctt aat ttt atg ctg act cag ccc cac tct 432
Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His Ser 130
135 140 gtg tcg ggg tct ccg ggg aag acg gta acc atc tcc tgc acc ggc
agc 480 Val Ser Gly Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly
Ser 145 150 155 160 agt ggc agc att gcc agc aac tat gtg cag tgg tac
cag cag cgc ccg 528 Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr
Gln Gln Arg Pro 165 170 175 ggc agt gcc ccc acc act gtg atc tat gag
gat aac caa aga ccc tct 576 Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu
Asp Asn Gln Arg Pro Ser 180 185 190 ggg gtc cct gat cgg ttc tct ggc
tcc atc gac cgc tcc tcc aac tct 624 Gly Val Pro Asp Arg Phe Ser Gly
Ser Ile Asp Arg Ser Ser Asn Ser 195 200 205 gcc tcc ctc acc atc tct
gga ctg aag act gag gac gag gct gac tac 672 Ala Ser Leu Thr Ile Ser
Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr 210 215 220 tac tgt cag tct
tct gat acc atg ttc cag gtg ttc ggc gga ggg acc 720 Tyr Cys Gln Ser
Ser Asp Thr Met Phe Gln Val Phe Gly Gly Gly Thr 225 230 235 240 aag
ctg acc gtc cta ggt 738 Lys Leu Thr Val Leu Gly 245 <210> SEQ
ID NO 94 <211> LENGTH: 738 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(738) <223> OTHER
INFORMATION: Polynucleotide encoding RGC0114 scFv protein
<400> SEQUENCE: 94 cag atg cag ctg gtg cag tct ggg gct gag
gtg aag aag cct ggg tcc 48 Gln Met Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ser 1 5 10 15 tcg gtg aag gtc tcc tgc aag gct
tct gga gga acc ttc agc agc tct 96 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Gly Thr Phe Ser Ser Ser 20 25 30 tca atc aat tgg gtg cga
cag gcc cct gga caa gga ctt gag tgg atg 144 Ser Ile Asn Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga gtg atc atc
tct aat ctt ggt aca cca tat tat gca cag agt ttc 192 Gly Val Ile Ile
Ser Asn Leu Gly Thr Pro Tyr Tyr Ala Gln Ser Phe 50 55 60 cag ggc
aga gtc acg ata tcc gcg gac aaa tct acg ggg act gtc tac 240 Gln Gly
Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Gly Thr Val Tyr 65 70 75 80
ctg gac gtg agt agc ctg aga tct gac gac tcg gcc acg tat tac tgt 288
Leu Asp Val Ser Ser Leu Arg Ser Asp Asp Ser Ala Thr Tyr Tyr Cys 85
90 95 gcg aga gct cgc cgg ctg tgg cag act ttt gac atc tgg ggc aag
gga 336 Ala Arg Ala Arg Arg Leu Trp Gln Thr Phe Asp Ile Trp Gly Lys
Gly 100 105 110 acc ctg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc
gga ggt ggc 384 Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 115 120 125 tct ggc ggt ggc gga agt gca cag tct gtg ctg
acg cag ccg ccc tca 432 Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu
Thr Gln Pro Pro Ser 130 135 140 gcg tct ggg gcc ccc ggg cag agg gtc
gtc atc tca tgt tct gga agc 480 Ala Ser Gly Ala Pro Gly Gln Arg Val
Val Ile Ser Cys Ser Gly Ser 145 150 155 160 acg tcc agc att gga agt
aat act gtg aac tgg tac aaa cac gtc cca 528 Thr Ser Ser Ile Gly Ser
Asn Thr Val Asn Trp Tyr Lys His Val Pro 165 170 175 gga gag gcc ccc
aaa ctc ctc atc tac agt tcc act cag cgg ccc tca 576 Gly Glu Ala Pro
Lys Leu Leu Ile Tyr Ser Ser Thr Gln Arg Pro Ser 180 185 190 ggg gtc
cct ggc cgc ttc tct ggc tcc acg tct ggc acc tca ggc tcc 624 Gly Val
Pro Gly Arg Phe Ser Gly Ser Thr Ser Gly Thr Ser Gly Ser 195 200 205
ctg acc atc agt ggg ctc cag tct ggg gat gag gct gat tac tac tgt 672
Leu Thr Ile Ser Gly Leu Gln Ser Gly Asp Glu Ala Asp Tyr Tyr Cys 210
215 220 gca gca ttt gat gac agc ctg aat ggt ttt gtc ttc gga act ggg
acc 720 Ala Ala Phe Asp Asp Ser Leu Asn Gly Phe Val Phe Gly Thr Gly
Thr 225 230 235 240 aag ctg acc gtc cta ggt 738 Lys Leu Thr Val Leu
Gly 245 <210> SEQ ID NO 95 <211> LENGTH: 726
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(726) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0115 scFv protein <400> SEQUENCE: 95 cag gtc acc
ttg aag gag tct ggg gga ggt gtg gta cgg cct ggg ggg 48 Gln Val Thr
Leu Lys Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt gat gat tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25
30 ggc atg agc tgg gtc cgc caa gct cca ggg aag ggg ctg gag tgg gtc
144 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tct ggt att aat tgg aat ggt ggt agc aca ggt tat gca gac
tct gtg 192 Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp
Ser Val 50 55 60 aag ggc cga ttc acc atc tcc aga gac aac gcc aag
aac tcc ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys
Asn Ser Leu Tyr 65 70 75 80 ctg caa atg aac agt ctg aga gcc gag gac
aca gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gca aga agg cgg tat gcg ttg gat
tat tgg ggc aag gga acc ctg gtc 336 Ala Arg Arg Arg Tyr Ala Leu Asp
Tyr Trp Gly Lys Gly Thr Leu Val 100 105 110 acc gtc tcg agt gga ggc
ggc ggt tca ggc gga ggt ggc tct ggc ggt 384 Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 ggc gga agt gca
ctt tct tct gag ctg act cag gac cct gct gtg tct 432 Gly Gly Ser Ala
Leu Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser 130 135 140 gtg gcc
ttg gga cag aca gtc agg atc aca tgc caa gga gac agc ctc 480 Val Ala
Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 145 150 155
160 aga aac tat tat gca agc tgg tac cag cag aag cca gga cag gcc cct
528 Arg Asn Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
165 170 175 gta ctt gtc atc tat ggt aaa aac aat cgg ccc tca ggg atc
cca gtc 576 Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile
Pro Val 180 185 190 cga ttc tct ggc tcc agc tca gga aac aca gct tcc
ttg acc atc act 624 Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser
Leu Thr Ile Thr 195 200 205 ggg act cag gcg gaa gat gga gct gac tat
tac tgt aac tcc cgg gac 672 Gly Thr Gln Ala Glu Asp Gly Ala Asp Tyr
Tyr Cys Asn Ser Arg Asp 210 215 220 agc agt ggt aag cat gtg ata ttc
ggc gga ggg acc aag gtc acc gtc 720 Ser Ser Gly Lys His Val Ile Phe
Gly Gly Gly Thr Lys Val Thr Val 225 230 235 240 cta ggt 726 Leu Gly
<210> SEQ ID NO 96 <211> LENGTH: 756 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(756)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0128 scFv
protein <400> SEQUENCE: 96 gag gtg cag ctg gtg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Val Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctc aga ctc tcc tgt
gaa gcc tct gga ttc agc ttt agt agt tat 96 Ser Leu Arg Leu Ser Cys
Glu Ala Ser Gly Phe Ser Phe Ser Ser Tyr 20 25 30 ggc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Gly Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tct agt
atc act agt cgt ggt cgt ggt gga agt aca tac cac gca gat 192 Ser Ser
Ile Thr Ser Arg Gly Arg Gly Gly Ser Thr Tyr His Ala Asp 50 55 60
tac gtg gag ggc cgg ttc acc atc tcc aga gac gat gcc aag aac acg 240
Tyr Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 65
70 75 80 ctg tat ctg caa atg aac agc ctg cga gcc gag gac acg gcc
gta tat 288 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr 85 90 95 tat tgt gca aaa gat tgg agt gcc tac gat agc gtc
cac ctc ttt gac 336 Tyr Cys Ala Lys Asp Trp Ser Ala Tyr Asp Ser Val
His Leu Phe Asp 100 105 110 tac tgg ggc cga gga acc ctg gtc acc gtc
tcg agt gga ggc ggc ggt 384 Tyr Trp Gly Arg Gly Thr Leu Val Thr Val
Ser Ser Gly Gly Gly Gly 115 120 125 tca ggc gga ggt ggc tct ggc ggt
ggc gga agt gca ctt aat ttt atg 432 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Leu Asn Phe Met 130 135 140 ctg act cag ccc cac tct
gtg tcg gag tct ccg ggg aag acg gta acc 480 Leu Thr Gln Pro His Ser
Val Ser Glu Ser Pro Gly Lys Thr Val Thr 145 150 155 160 atc tcc tgc
acc cgc aac act gac aac att gcc ttc aac tat gtg cag 528 Ile Ser Cys
Thr Arg Asn Thr Asp Asn Ile Ala Phe Asn Tyr Val Gln 165 170 175 tgg
ttc cag cag cgc ccg ggc agt tcc ccc acc act gtg atc tat gag 576 Trp
Phe Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu 180 185
190 gat aac caa aga ccc tct ggg gtc cct gat cgg ttc tct ggc tcc atc
624 Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile
195 200 205 gac agc tcc tcc aac tct gcc tcc ctc acc atc tct gga ctg
aag act 672 Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu
Lys Thr 210 215 220 gag gac gag gct gac tac tac tgt cag tct tat gat
ggc aac aat ctg 720 Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp
Gly Asn Asn Leu 225 230 235 240 gtg ttc ggc gga ggg acc aag ctg acc
gtc cta ggt 756 Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245
250 <210> SEQ ID NO 97 <211> LENGTH: 747 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(747)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0130 scFv
protein <400> SEQUENCE: 97 gaa gtg cag ctg gtg cag tct gga
gct gag gtg aag aag cct ggg gcc 48 Glu Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 tca gtg aag gtc tcc tgc
aag gct tct ggt tac acc ttt acc agc tat 96 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 ggt atc agc tgg
gtg cga cag gcc cct gga caa ggg ctt gag tgg atg 144 Gly Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga tgg
atc agc gct tac aat ggt aac aca aac tat gca cag aag ctc 192 Gly Trp
Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 50 55 60
cag ggc aga gtc acc atg acc aca gac aca tcc acg agc aca gcc tac 240
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65
70 75 80 atg gag ctg agg agc ctg aga tct gac gac acg gcc gtg tat
tac tgt 288 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga gat gcc cga cct cgg ggt ata gca gct cgt
cca tta ctt agc 336 Ala Arg Asp Ala Arg Pro Arg Gly Ile Ala Ala Arg
Pro Leu Leu Ser 100 105 110 tac tgg ggg agg ggg acc acg gtc acc gtc
tct tca ggt gga ggc ggt 384 Tyr Trp Gly Arg Gly Thr Thr Val Thr Val
Ser Ser Gly Gly Gly Gly 115 120 125 tca ggc gga ggt ggc agc ggc ggt
ggc gga tcg cag tct gtg ttg acg 432 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gln Ser Val Leu Thr 130 135 140 cag ccg ccc tca gtg tct
gcg gcc cca gga gag aag gtc acc att tcc 480 Gln Pro Pro Ser Val Ser
Ala Ala Pro Gly Glu Lys Val Thr Ile Ser 145 150 155 160 tgc tct gga
agc acc tcc aac att ggg aat aat tat gtc tcc tgg tac 528 Cys Ser Gly
Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp Tyr 165 170 175 caa
cag cac cca ggc aaa gcc ccc aaa ctc atg att tat gat gtc agt 576 Gln
Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser 180 185
190 aag cgg ccc tca ggg gtc cct gac cga ttc tct ggc tcc aag tct ggc
624 Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly
195 200 205 aac acg gcg tcc ctg acc atc tct ggg gtc cag gct gag gac
gag gct 672 Asn Thr Ala Ser Leu Thr Ile Ser Gly Val Gln Ala Glu Asp
Glu Ala 210 215 220 gat tat tac tgc agc tca tat aca agc gcc agc act
gtg ata ttc ggc 720 Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ala Ser Thr
Val Ile Phe Gly 225 230 235 240 gga ggg acc aag ctg acc gtc cta ggt
747 Gly Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
98 <211> LENGTH: 771 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(771) <223> OTHER
INFORMATION: Polynucleotide encoding RGC0131 scFv protein
<400> SEQUENCE: 98 cag gtg cag ctg gtg cag tct ggg gct gaa
gtg agg aag cct ggg gcc 48 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Arg Lys Pro Gly Ala 1 5 10 15 tca gtg agg gtc tcc tgc agg gct
tct gga tac agc ttc acg aat tat 96 Ser Val Arg Val Ser Cys Arg Ala
Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 gat atc aac tgg gtg cga
cag gcc cct ggg caa ggg ctt gag tgg atg 144 Asp Ile Asn Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 ggc tgg atg aac
cct aac ggc ggt cac aca ggc tct gca cag aag ttc 192 Gly Trp Met Asn
Pro Asn Gly Gly His Thr Gly Ser Ala Gln Lys Phe 50 55 60 cag ggc
aga gtc acc atg acc agg gac acc tcc ata aac act gcc tac 240 Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80
atg gag ctg agc agc ctg aca tct gac gac acg gcc gtc tat tac tgt 288
Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga ggg tct cag tgg tgt act ggt ggt aac tgc tac gga aca
cac 336 Ala Arg Gly Ser Gln Trp Cys Thr Gly Gly Asn Cys Tyr Gly Thr
His 100 105 110 tac tac tac atg gag gac tgg ggc cga gga acc ctg gtc
acc gtc tcg 384 Tyr Tyr Tyr Met Glu Asp Trp Gly Arg Gly Thr Leu Val
Thr Val Ser 115 120 125 agt gga ggc ggc ggt tca ggc gga ggt ggc tct
ggc ggt ggc gga agt 432 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 130 135 140 gca ctt aat ttt atg ctg act cag ccc
cac tct gtg tcg gag tct ccg 480 Ala Leu Asn Phe Met Leu Thr Gln Pro
His Ser Val Ser Glu Ser Pro 145 150 155 160 ggg aag acg gta acc atc
tcc tgc acc cgc aac act gac aac att gcc 528 Gly Lys Thr Val Thr Ile
Ser Cys Thr Arg Asn Thr Asp Asn Ile Ala 165 170 175 ttc aac tat gtg
cag tgg ttc cag cag cgc ccg ggc agt tcc ccc acc 576 Phe Asn Tyr Val
Gln Trp Phe Gln Gln Arg Pro Gly Ser Ser Pro Thr 180 185 190 act gtg
atc tat gag gat aac caa aga ccc tct ggg gtc cct gat cgg 624 Thr Val
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 195 200 205
ttc tct ggc tcc atc gac agc tcc tcc aac tct gcc tcc ctc acc atc 672
Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile 210
215 220 tct gga ctg aag act gag gac gag gct gac tac tac tgt cag tct
tat 720 Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser
Tyr 225 230 235 240 gat ggc aac aat ctg gtg ttc ggc gga ggg acc aag
ctg acc gtc cta 768 Asp Gly Asn Asn Leu Val Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu 245 250 255 ggt 771 Gly <210> SEQ ID NO 99
<211> LENGTH: 732 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(732) <223> OTHER INFORMATION:
Polynucleotide encoding RGC0137 scFv protein <400> SEQUENCE:
99 gag gtg cag ctg gtg cag tct ggg tct gag gtg aag aag cct ggg tcg
48 Glu Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ser
1 5 10 15 tca gtg aga gtc tcc tgc aag act tct gga gac acc ttc agg
agg ttt 96 Ser Val Arg Val Ser Cys Lys Thr Ser Gly Asp Thr Phe Arg
Arg Phe 20 25 30 act gtc agt tgg gtg cga cag gcc cct gga cag ggg
ctt gag tgg atg 144 Thr Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Met 35 40 45 gga agg gtc atc cct ctc tac aat tct cca
acc tac gcc cag aag ttc 192 Gly Arg Val Ile Pro Leu Tyr Asn Ser Pro
Thr Tyr Ala Gln Lys Phe 50 55 60 cag gac aga gtc acg att acc gcg
gac gaa tcc acg acc aca gtc tac 240 Gln Asp Arg Val Thr Ile Thr Ala
Asp Glu Ser Thr Thr Thr Val Tyr 65 70 75 80 atg gag gtg acc ggc ctg
aca tct gaa gac acc gcc gtc tat tac tgt 288 Met Glu Val Thr Gly Leu
Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gac tcc
ccc ccc tac aat gca gac ttt gat tca tgg ggc caa 336 Ala Arg Asp Ser
Pro Pro Tyr Asn Ala Asp Phe Asp Ser Trp Gly Gln 100 105 110 ggg aca
atg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc gga ggt 384 Gly Thr
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125
ggc tct ggc ggt ggc gga agt gca cag gct gtg ctg act cag ccg tcg 432
Gly Ser Gly Gly Gly Gly Ser Ala Gln Ala Val Leu Thr Gln Pro Ser 130
135 140 tca atg tct gtg tcc ccg gga cag acg gcc atc atc acc tgc tct
gga 480 Ser Met Ser Val Ser Pro Gly Gln Thr Ala Ile Ile Thr Cys Ser
Gly 145 150 155 160 aat aga ttg ggg gac aaa tat gtt tcg tgg tat cag
cag agg cca ggc 528 Asn Arg Leu Gly Asp Lys Tyr Val Ser Trp Tyr Gln
Gln Arg Pro Gly 165 170 175 cag tcc cct gtc ctg gtc ata ttt caa gat
aac aag agg ccc tca gga 576 Gln Ser Pro Val Leu Val Ile Phe Gln Asp
Asn Lys Arg Pro Ser Gly 180 185 190 att tct gag cga ttc tct ggc tcc
aac tct ggc aac aca gcc act ctg 624 Ile Ser Glu Arg Phe Ser Gly Ser
Asn Ser Gly Asn Thr Ala Thr Leu 195 200 205 acc atc agc gac gtc gag
gcc atg gat gag gct gaa tat ttc tgt cag 672 Thr Ile Ser Asp Val Glu
Ala Met Asp Glu Ala Glu Tyr Phe Cys Gln 210 215 220 gcg tgg cac agt
agt ttt tat tat gcc ttc gga act ggg acc aag ctg 720 Ala Trp His Ser
Ser Phe Tyr Tyr Ala Phe Gly Thr Gly Thr Lys Leu 225 230 235 240 acc
gtc cta ggt 732 Thr Val Leu Gly <210> SEQ ID NO 100
<211> LENGTH: 744 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(744) <223> OTHER INFORMATION:
Polynucleotide encoding RGC0139 scFv protein <400> SEQUENCE:
100 gag gtg cag ctg gtg cag tct ggg gct gaa gtg aag gag ccg ggg gcc
48 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala
1 5 10 15 tca atg aag gtt tac tgc aag gca tct gga tac agg ttc acc
agg tat 96 Ser Met Lys Val Tyr Cys Lys Ala Ser Gly Tyr Arg Phe Thr
Arg Tyr 20 25 30 tat ata cat tgg gta cga cag gcc cct gga caa ggg
ctt gag tgg atg 144 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Met 35 40 45 gga aca atc aac cct agt gat ggt agc aca
agt tac gca cag aag ttc 192 Gly Thr Ile Asn Pro Ser Asp Gly Ser Thr
Ser Tyr Ala Gln Lys Phe 50 55 60 cag gac aga gtc act atg acc agg
gac acg tcc acg aga aca gtc tac 240 Gln Asp Arg Val Thr Met Thr Arg
Asp Thr Ser Thr Arg Thr Val Tyr 65 70 75 80 atg gag ttg agc agc ctg
aga tct gag gac acg gcc atg tat tac tgt 288 Met Glu Leu Ser Ser Leu
Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 ggg aga gtg gag
gac tat tac tct gaa agt aat ggt cca gct gat aac 336 Gly Arg Val Glu
Asp Tyr Tyr Ser Glu Ser Asn Gly Pro Ala Asp Asn 100 105 110 tgg ggc
cgg ggg aca atg gtc acc gtc tcg agt gga ggc ggc ggt tca 384 Trp Gly
Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125
ggc gga ggt ggc tct ggc ggt ggc gga agt gca cag tct gtg ctg acg 432
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr 130
135 140 cag ccg ccc tcg gtg tca gtg gcc cca gga cag acg gcc agc att
acc 480 Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Ser Ile
Thr 145 150 155 160 tgt ggg gga aac aag att ggg act aaa ggt gtg cac
tgg tac cag cag 528 Cys Gly Gly Asn Lys Ile Gly Thr Lys Gly Val His
Trp Tyr Gln Gln 165 170 175 aag cca ggc cgg gcc cct gtg ctg gtc gtc
tat gat gat ggc gac cgg 576 Lys Pro Gly Arg Ala Pro Val Leu Val Val
Tyr Asp Asp Gly Asp Arg 180 185 190 ccc tca ggg atc cct gac cga ttc
tct ggc tcc aac tct gac aac acg 624 Pro Ser Gly Ile Pro Asp Arg Phe
Ser Gly Ser Asn Ser Asp Asn Thr 195 200 205 gcc acc ctg acc atc agc
agg gtc gaa gcc ggg gat gag gcc gac tat 672 Ala Thr Leu Thr Ile Ser
Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr 210 215 220 tac tgt cag gtg
tgg gat agt gat agt gat cta ggg gta ttc ggc gga 720 Tyr Cys Gln Val
Trp Asp Ser Asp Ser Asp Leu Gly Val Phe Gly Gly 225 230 235 240 ggg
acc aag gtc acc gtc cta ggt 744 Gly Thr Lys Val Thr Val Leu Gly 245
<210> SEQ ID NO 101 <211> LENGTH: 729 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(729)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0142 scFv
protein <400> SEQUENCE: 101 gaa gtg cag ctg gtg cag tct ggg
gct gcg gtg aag aag cct ggg tcg 48 Glu Val Gln Leu Val Gln Ser Gly
Ala Ala Val Lys Lys Pro Gly Ser 1 5 10 15 tcg gtg aag att tcg tgc
gag gtt tct ggg ggc atc ttc aag aac tat 96 Ser Val Lys Ile Ser Cys
Glu Val Ser Gly Gly Ile Phe Lys Asn Tyr 20 25 30 gct atc agc tgg
gtg cga cag gcc cct gga caa gga ctt gag tgg atg 144 Ala Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga gga
agc atc cct atg tat ggg aca cca agt tac gct ccg aag ttc 192 Gly Gly
Ser Ile Pro Met Tyr Gly Thr Pro Ser Tyr Ala Pro Lys Phe 50 55 60
cag ggc aga gtc act att atc gcg gac gaa tct acg agc aca gcc tac 240
Gln Gly Arg Val Thr Ile Ile Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65
70 75 80 atg gag ctg agc agc ctg aga tct gag gac acg gcc atg tac
tac tgt 288 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr
Tyr Cys 85 90 95 gcg cgg gag aca act gaa gtc gat gac gct ttt gat
atc tgg ggc aga 336 Ala Arg Glu Thr Thr Glu Val Asp Asp Ala Phe Asp
Ile Trp Gly Arg 100 105 110 ggg aca atg gtc acc gtc tcg agt gga ggc
ggc ggt tca ggc gga ggt 384 Gly Thr Met Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca
cag tct gtg ttg acg cag ccg ccc 432 Gly Ser Gly Gly Gly Gly Ser Ala
Gln Ser Val Leu Thr Gln Pro Pro 130 135 140 tcg gtg tct gca gcc ccc
agg cag agg gtc acc atc tcc tgt tct gga 480 Ser Val Ser Ala Ala Pro
Arg Gln Arg Val Thr Ile Ser Cys Ser Gly 145 150 155 160 agc agt tcc
aac atc gga aat aat gtt gtg aac tgg tac cag cac ttc 528 Ser Ser Ser
Asn Ile Gly Asn Asn Val Val Asn Trp Tyr Gln His Phe 165 170 175 ccg
gga aag gct ccc agg ctc ctc atc ttc tct gat agt ctc ctg tcc 576 Pro
Gly Lys Ala Pro Arg Leu Leu Ile Phe Ser Asp Ser Leu Leu Ser 180 185
190 gac cga ttc tct ggc tcc aag tcc ggc acc tca gcc tcc ctg gcc atc
624 Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile
195 200 205 agt gga ctg cag tct gac gat gag gct gaa tat tac tgt gcg
tca tgg 672 Ser Gly Leu Gln Ser Asp Asp Glu Ala Glu Tyr Tyr Cys Ala
Ser Trp 210 215 220 gat gac agc ctg aat ggt ttg gtt ttc ggc gga ggg
acc aag ctg acc 720 Asp Asp Ser Leu Asn Gly Leu Val Phe Gly Gly Gly
Thr Lys Leu Thr 225 230 235 240 gtc cta ggt 729 Val Leu Gly
<210> SEQ ID NO 102 <211> LENGTH: 729 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(729)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0145 scFv
protein <400> SEQUENCE: 102 gag gtc cag ctg gtg cag tct ggg
gct gag gtg aag aag cct ggg tcg 48 Glu Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 tcg gtg aag att tcc tgc
gag gtt tct ggg ggc atc ttc aag aac tat 96 Ser Val Lys Ile Ser Cys
Glu Val Ser Gly Gly Ile Phe Lys Asn Tyr 20 25 30 gct atc agc tgg
gtg cga cag gcc cct gga caa gga ctt gag tgg atg 144 Ala Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga gga
agc atc cct atg tat ggg aca cca agt tac gct ccg aag ttc 192 Gly Gly
Ser Ile Pro Met Tyr Gly Thr Pro Ser Tyr Ala Pro Lys Phe 50 55 60
cag ggc aga gtc act att atc gcg gac gaa tct acg agc aca gcc tac 240
Gln Gly Arg Val Thr Ile Ile Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65
70 75 80 atg gag ctg agc agc ctg aga tct gag gac acg gcc atg tac
tac tgt 288 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr
Tyr Cys 85 90 95 gcg cgg gag aca act gaa gtc gat gac gct ttt aat
atc tgg ggc aga 336 Ala Arg Glu Thr Thr Glu Val Asp Asp Ala Phe Asn
Ile Trp Gly Arg 100 105 110 ggc acc ctg gtc acc gtc tcg agt gga ggc
ggc ggt tca ggc gga ggt 384 Gly Thr Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca
cag tct gtg ctg acg cag ccg ccc 432 Gly Ser Gly Gly Gly Gly Ser Ala
Gln Ser Val Leu Thr Gln Pro Pro 130 135 140 tcg gtg tct gca gcc ccc
agg cag agg gtc acc atc tcc tgt tct gga 480 Ser Val Ser Ala Ala Pro
Arg Gln Arg Val Thr Ile Ser Cys Ser Gly 145 150 155 160 agc agt tcc
aac atc gga aat aat gtt gtg aac tgg tac cag cac ttc 528 Ser Ser Ser
Asn Ile Gly Asn Asn Val Val Asn Trp Tyr Gln His Phe 165 170 175 ccg
gga aag gct ccc agg ctc ctc atc ttt cct gat agt ctc ctg tcc 576 Pro
Gly Lys Ala Pro Arg Leu Leu Ile Phe Pro Asp Ser Leu Leu Ser 180 185
190 gac cga ttc tct ggc tcc aag tcc ggc acc tca gcc tcc ctg gcc atc
624 Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile
195 200 205 agt ggg ctg cag tct gac gat gag gct gaa tat tac tgt gcg
tca tgg 672 Ser Gly Leu Gln Ser Asp Asp Glu Ala Glu Tyr Tyr Cys Ala
Ser Trp 210 215 220 gat gac agc ctg aat ggt ttg gtt ttc ggc gga ggg
acc aag ctg acc 720 Asp Asp Ser Leu Asn Gly Leu Val Phe Gly Gly Gly
Thr Lys Leu Thr 225 230 235 240 gtc cta ggt 729 Val Leu Gly
<210> SEQ ID NO 103 <211> LENGTH: 747 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(747)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0150 scFv
protein <400> SEQUENCE: 103 cag gtg cag ctg cag gag tcg ggc
cca gga ctg gtg aag cct tcg ggg 48 Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Pro Ser Gly 1 5 10 15 acc ctg tcc ctc acc tgc
gct gtc tct ggt ggc tcc atc agc agt agt 96 Thr Leu Ser Leu Thr Cys
Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 aac tac tgg agt
tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg 144 Asn Tyr Trp Ser
Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 att ggg
gag atc tat cat gat ggg agc acc aac tac aac ccg tcc ctc 192 Ile Gly
Glu Ile Tyr His Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu 50 55 60
aag agt cga gtc acc atg tca gca gac aag tcc aag aac cag ttc tcc 240
Lys Ser Arg Val Thr Met Ser Ala Asp Lys Ser Lys Asn Gln Phe Ser 65
70 75 80 ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat
tac tgt 288 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga gat tcc ccc tcg tat agc agt ggc tgg tac
tct gac tac tgg 336 Ala Arg Asp Ser Pro Ser Tyr Ser Ser Gly Trp Tyr
Ser Asp Tyr Trp 100 105 110 ggc caa ggc acc ctg gtc acc gtc tcg agt
gga ggc ggc ggt tca ggc 384 Gly Gln Gly Thr Leu Val Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly 115 120 125 gga ggt ggc tct ggc ggt ggc gga
agt gca cag tct gtg ttg acg cag 432 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ala Gln Ser Val Leu Thr Gln 130 135 140 ccg ccc tca gcg tct ggg
acc ccc ggg cgg agg gtc acc atc tct tgt 480 Pro Pro Ser Ala Ser Gly
Thr Pro Gly Arg Arg Val Thr Ile Ser Cys 145 150 155 160 tcc ggg agc
agc tcc aac atc gga agt aac cct gta aac tgg tac cag 528 Ser Gly Ser
Ser Ser Asn Ile Gly Ser Asn Pro Val Asn Trp Tyr Gln 165 170 175 caa
ctc cca gga acg gcc ccc aaa atc gtc atg tat agt act gat cag 576 Gln
Leu Pro Gly Thr Ala Pro Lys Ile Val Met Tyr Ser Thr Asp Gln 180 185
190 cgg acc tca ggg gcc cct gac cga ttc tct ggc tcc aag tct ggc acc
624 Arg Thr Ser Gly Ala Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr
195 200 205 tca gcc tcc ctg gcc atc act ggg ctc cag tct gag gat gag
gct gat 672 Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ser Glu Asp Glu
Ala Asp 210 215 220 tat ttc tgt gca aca tgg gat gac agc ccg aat gcc
gtg gta ttc ggc 720 Tyr Phe Cys Ala Thr Trp Asp Asp Ser Pro Asn Ala
Val Val Phe Gly 225 230 235 240 gga ggg acc aag ctg acc gtc cta ggt
747 Gly Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
104 <211> LENGTH: 753 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(753) <223> OTHER
INFORMATION: Polynucleotide encoding RGC0153 scFv protein
<400> SEQUENCE: 104 gaa gtg cag ctg gtg cag tct ggg gct gag
gtg aag aag cct ggg gcc 48 Glu Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 tca gtg aag gtc tcc tgc aag gct
tct ggc tac acc ttc acc ggc gac 96 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Gly Asp 20 25 30 tat ttg cac tgg gtg cga
cag gcc cct gga caa ggg ctt gag tgg atg 144 Tyr Leu His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga tgg atc aac
cct aac act ggt ggc aca aac tat gca cag aag ttt 192 Gly Trp Ile Asn
Pro Asn Thr Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60 cag ggc
agg gtc acc atg acc agg gac acg tcc atc agc aca gcg tac 240 Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80
atg gag ttg agc agg ctg aga tct gac gac acg gcc atc tat tac tgt 288
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 85
90 95 gcg aga gcg cga tat tac tat gac agt act agt tac ccc ttt gac
tac 336 Ala Arg Ala Arg Tyr Tyr Tyr Asp Ser Thr Ser Tyr Pro Phe Asp
Tyr 100 105 110 tgg ggc cgg gga acc ctg gtc acc gtc tcg agt gga ggc
ggc ggt tca 384 Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser 115 120 125 ggc gga ggt ggc tct ggc ggt ggc gga agt gca
ctt aat ttt atg ctg 432 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
Leu Asn Phe Met Leu 130 135 140 act cag ccc cac tct gtg tcg gag tct
ccg ggt aag aca gta act ctc 480 Thr Gln Pro His Ser Val Ser Glu Ser
Pro Gly Lys Thr Val Thr Leu 145 150 155 160 tcc tgc acc cgc tcc agt
ggc agc att tca ttc gac tat gtg cag tgg 528 Ser Cys Thr Arg Ser Ser
Gly Ser Ile Ser Phe Asp Tyr Val Gln Trp 165 170 175 tat caa cag cgg
ccg ggc agc tcc ccc att ctt gtg atc ttt gaa gat 576 Tyr Gln Gln Arg
Pro Gly Ser Ser Pro Ile Leu Val Ile Phe Glu Asp 180 185 190 gac caa
aga ccc tct ggg gtc cct gat cga ttc tct ggc tcc atc gac 624 Asp Gln
Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp 195 200 205
agt acc tcc aac tct gcc tcc ctc acc atc tct ggc ctg cag agt gag 672
Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu 210
215 220 gac gag ggt gac tac tat tgt cag act tat gat gac aac cgt cag
gtg 720 Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp Asp Asn Arg Gln
Val 225 230 235 240 ttc ggc ggg ggg acc aag gtc acc gtc cta ggt 753
Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 245 250 <210> SEQ
ID NO 105 <211> LENGTH: 735 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(735) <223> OTHER
INFORMATION: Polynucleotide encoding RGC0154 scFv protein
<400> SEQUENCE: 105 cag gtc cag ctg gtg cag tct ggg gct gag
gtg agg aag cct ggg tcc 48 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Arg Lys Pro Gly Ser 1 5 10 15 tca gtg aag gtc tcc tgc acg acc
tct gaa aac acc ttt agg agg tct 96 Ser Val Lys Val Ser Cys Thr Thr
Ser Glu Asn Thr Phe Arg Arg Ser 20 25 30 agt ttc agt tgg cta cgc
cag gcc cct gga caa ggt ctt gag tgg atg 144 Ser Phe Ser Trp Leu Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga agg atc atc
cct atc att cat tct gaa acc tac gca cag aac ttt 192 Gly Arg Ile Ile
Pro Ile Ile His Ser Glu Thr Tyr Ala Gln Asn Phe 50 55 60 cag ggc
agg gtc acc atg acc gcg gac gaa tct acg agt aca gtc tat 240 Gln Gly
Arg Val Thr Met Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 65 70 75 80
gtg gag gtg aga agc ctg aga tct gaa gac acg gcc gtc tat tac tgt 288
Val Glu Val Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga gac tcc ccc ccc tac aat gca gac ttt gat ttc tgg ggc
caa 336 Ala Arg Asp Ser Pro Pro Tyr Asn Ala Asp Phe Asp Phe Trp Gly
Gln 100 105 110 gga acc ctg gtc acc gtc tcg agt gga ggc ggc ggt tca
ggc gga ggt 384 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca ctt tcc tat
gag ctg act cag cca 432 Gly Ser Gly Gly Gly Gly Ser Ala Leu Ser Tyr
Glu Leu Thr Gln Pro 130 135 140 ccc tca gtg tcc gtg tcc cca gga cag
aca gcc agc atc acc tgt tct 480 Pro Ser Val Ser Val Ser Pro Gly Gln
Thr Ala Ser Ile Thr Cys Ser 145 150 155 160 gga gat aac tta ggg gat
aag tat gtt agt tgg tat cag cag agg cca 528 Gly Asp Asn Leu Gly Asp
Lys Tyr Val Ser Trp Tyr Gln Gln Arg Pro 165 170 175 ggc cag tcc cct
gtt ctg gtc atc tat caa gat gtc aag cgg ccc tct 576 Gly Gln Ser Pro
Val Leu Val Ile Tyr Gln Asp Val Lys Arg Pro Ser 180 185 190 ggg att
cct gag cga ttc tct ggc tcc aac tct ggg aac aca gcc act 624 Gly Ile
Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 195 200 205
ctg acc atc agc ggg acc cag gct atg gat gag gct gac tac tac tgt 672
Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys 210
215 220 cag gcg tgg gac agt aac act tct tat gtc ttc gga act ggg acc
cag 720 Gln Ala Trp Asp Ser Asn Thr Ser Tyr Val Phe Gly Thr Gly Thr
Gln 225 230 235 240 ctc acc gtt tta agt 735 Leu Thr Val Leu Ser 245
<210> SEQ ID NO 106 <211> LENGTH: 759 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(759)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0157 scFv
protein <400> SEQUENCE: 106 cag gta cag ctg cag cag tcg ggg
gct gag gtg aag aag cct ggg tcc 48 Gln Val Gln Leu Gln Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 tcg gtg aag gtc tcc tgc
aag gct tct gga ggc acc ttc aac agt tct 96 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Gly Thr Phe Asn Ser Ser 20 25 30 gct atc agt tgg
gtg cga cag gcc cct gga caa ggg ctt gag tgg atg 144 Ala Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga agg
atc atc cct atc ctt ggt ata gca aac tac gca cag aat ttc 192 Gly Arg
Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Asn Phe 50 55 60
cag gac aga gtc acg att acc gcg gac aaa tcc acg agc aca gcc tac 240
Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65
70 75 80 atg gag ctg agc agc ctg aca tct gag gac acg gcc gtt tat
tac tgt 288 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 acg aga gat tac gtg gat cca gat atg ctt acg gcc
gga tac tac ttt 336 Thr Arg Asp Tyr Val Asp Pro Asp Met Leu Thr Ala
Gly Tyr Tyr Phe 100 105 110 gac cag tgg ggc cag gga acc ctg gtc acc
gtc tcg agt gga ggc ggc 384 Asp Gln Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly 115 120 125 ggt tca ggc gga ggt ggc tct ggc
ggt ggc gga agt gca ctt aat ttt 432 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ala Leu Asn Phe 130 135 140 atg ctg act cag ccc cac
tct gtg tcg gag tct ccg ggg aag acg gta 480 Met Leu Thr Gln Pro His
Ser Val Ser Glu Ser Pro Gly Lys Thr Val 145 150 155 160 acc atc tcc
tgc acc cgc aac act gac aac att gcc ttc aac tat gtg 528 Thr Ile Ser
Cys Thr Arg Asn Thr Asp Asn Ile Ala Phe Asn Tyr Val 165 170 175 cag
tgg ttc cag cag cgc ccg ggc agt tcc ccc acc act gtg atc tat 576 Gln
Trp Phe Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr 180 185
190 gag gat aac caa aga ccc tct ggg gtc cct gat cgg ttc tct ggc tcc
624 Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser
195 200 205 atc gac agc tcc tcc aac tct gcc tcc ctc acc atc tct gga
ctg aag 672 Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
Leu Lys 210 215 220 act gag gac gag gct gac tac tac tgt cag tct tat
gat ggc aac aat 720 Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr
Asp Gly Asn Asn 225 230 235 240 ctg gtg ttc ggc gga ggg acc aag ctg
acc gtc cta ggt 759 Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
Gly 245 250 <210> SEQ ID NO 107 <211> LENGTH: 741
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(741) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0162 scFv protein <400> SEQUENCE: 107 cag gtg cag
ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc 48 Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 tca
gtg aag gtc tct tgc aag gct gct ggg ttc agg ttc agc ggc gac 96 Ser
Val Lys Val Ser Cys Lys Ala Ala Gly Phe Arg Phe Ser Gly Asp 20 25
30 tat ttg cac tgg ctg cga caa gtt cct gga caa ggg cct gag tgg atg
144 Tyr Leu His Trp Leu Arg Gln Val Pro Gly Gln Gly Pro Glu Trp Met
35 40 45 gga tgg atc aat ctc agc agt ggt ggc aca aat tat gga gag
aag ttt 192 Gly Trp Ile Asn Leu Ser Ser Gly Gly Thr Asn Tyr Gly Glu
Lys Phe 50 55 60 cag ggc cgg gtc acc atg acc agg gac agg ccc agt
agc aca gcc tac 240 Gln Gly Arg Val Thr Met Thr Arg Asp Arg Pro Ser
Ser Thr Ala Tyr 65 70 75 80 atg gaa ata aaa agt ctg aga gtt gac gac
acg gcc gta tat tat tgt 288 Met Glu Ile Lys Ser Leu Arg Val Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gag agc ccc gta gta gag
gcc atg gac gtc tgg ggc cgg gga 336 Ala Arg Glu Ser Pro Val Val Glu
Ala Met Asp Val Trp Gly Arg Gly 100 105 110 acc ctg gtc acc gtc tcg
agt gga ggc ggc ggt tca ggc gga ggt ggc 384 Thr Leu Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc
gga agt gca ctt aat ttt atg ctg act cag ccc cac 432 Ser Gly Gly Gly
Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 130 135 140 tct gtg
tca gag tct ccg ggg aag acg gta acc atc tcc tgc acc cgc 480 Ser Val
Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Arg 145 150 155
160 agc agt gac aac att gcc ttc aat tat gtg cag tgg tac cag cag cgc
528 Ser Ser Asp Asn Ile Ala Phe Asn Tyr Val Gln Trp Tyr Gln Gln Arg
165 170 175 ccg ggc agt gcc ccc acc act ttg att tat gag gat aac caa
aga cct 576 Pro Gly Ser Ala Pro Thr Thr Leu Ile Tyr Glu Asp Asn Gln
Arg Pro 180 185 190 tct ggg gtc cct gat cgg ttc tct ggc tcc atc gac
agc tcc tcc aac 624 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp
Ser Ser Ser Asn 195 200 205 tct gcc tcc ctc acc atc tct aat ctg aag
act gag gac gaa gct gac 672 Ser Ala Ser Leu Thr Ile Ser Asn Leu Lys
Thr Glu Asp Glu Ala Asp 210 215 220 tac tac tgt cag tct tat gat ggc
agt aat tat gtc ttc gga act ggg 720 Tyr Tyr Cys Gln Ser Tyr Asp Gly
Ser Asn Tyr Val Phe Gly Thr Gly 225 230 235 240 acc aag ctg acc gtc
cta ggt 741 Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
108 <211> LENGTH: 735 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(735) <223> OTHER
INFORMATION: Polynucleotide encoding RGC0164 scFv protein
<400> SEQUENCE: 108 gag gtc cag ctg gtg cag tct ggg gct gag
gtg aag aag cct ggg gcc 48 Glu Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 tca gtg aag gtc tcc tgc aag gcc
tct gga tac acc ttc acc ggc tac 96 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30 tat atg cac tgg gtg cga
cag gcc cct gga caa ggg ctt gag tgg atg 144 Tyr Met His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga tgg atc aat
cct aaa agc ggt ggc aca aac tat cca cag aag ttt 192 Gly Trp Ile Asn
Pro Lys Ser Gly Gly Thr Asn Tyr Pro Gln Lys Phe 50 55 60 cag ggc
agg gtc acc atg acc agg gac acg tcc atc agc aca gcc tac 240 Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80
atg gag ctg agc agg ctg aga tct gac gac acg gcc gta tat tac tgt 288
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga gag gga act ggg gac ttc ttt gac tac tgg ggc cgg gga
acc 336 Ala Arg Glu Gly Thr Gly Asp Phe Phe Asp Tyr Trp Gly Arg Gly
Thr 100 105 110 ctg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc gga
ggt ggc tct 384 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser 115 120 125 ggc ggt ggc gga agt gca cag cct gtg ctg act
cag ccc ccc tcc gcg 432 Gly Gly Gly Gly Ser Ala Gln Pro Val Leu Thr
Gln Pro Pro Ser Ala 130 135 140 tcc ggg tct cct gga cag tca gtc acc
atc tcc tgc act gga acc agc 480 Ser Gly Ser Pro Gly Gln Ser Val Thr
Ile Ser Cys Thr Gly Thr Ser 145 150 155 160 agt gac gtt ggt ggt tat
aac tat gtc tcc tgg tac caa cag cac cca 528 Ser Asp Val Gly Gly Tyr
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro 165 170 175 ggc aaa gcc ccc
aaa ctc atg att tat gag gtc agt aag cgg ccc tca 576 Gly Lys Ala Pro
Lys Leu Met Ile Tyr Glu Val Ser Lys Arg Pro Ser 180 185 190 ggg gtc
cct gat cgc ttc tct gcc tcc aag tct ggc aac acg gcc tcc 624 Gly Val
Pro Asp Arg Phe Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser 195 200 205
ctg acc gtc tct ggg ctc cag gct gag gat gag gct tat tat tac tgc 672
Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Tyr Tyr Tyr Cys 210
215 220 agc tca tat gca ggc agc aac aat tcg gta ttc ggc gga ggg acc
aag 720 Ser Ser Tyr Ala Gly Ser Asn Asn Ser Val Phe Gly Gly Gly Thr
Lys 225 230 235 240 ctg acc gtc cta ggt 735 Leu Thr Val Leu Gly 245
<210> SEQ ID NO 109 <211> LENGTH: 738 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(738)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0169 scFv
protein <400> SEQUENCE: 109 cag gtg cag ctg cag gag tcg ggt
gga ggc gtg gtc cag cct ggg ggg 48 Gln Val Gln Leu Gln Glu Ser Gly
Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcg tct gga ttc acc ttt aat att tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 20 25 30 ggc atg cac tgg
gtc cgc cag gct cca ggc aag ggg ccg gag tgg gtg 144 Gly Met His Trp
Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 35 40 45 gca gtt
att tgg tat gat gga agc aga caa tat tat gga gac tcc gtg 192 Ala Val
Ile Trp Tyr Asp Gly Ser Arg Gln Tyr Tyr Gly Asp Ser Val 50 55 60
aag ggc cga ttc acc atc tcc aga gac aac tcc aag aac aca gtg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg ggt gta tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr
Tyr Cys 85 90 95 gcg aga gac cct agt ctg gca cct gtg tac cag ttt
gac tac tgg ggc 336 Ala Arg Asp Pro Ser Leu Ala Pro Val Tyr Gln Phe
Asp Tyr Trp Gly 100 105 110 cgg ggg aca atg gtc acc gtc tcg agt gga
ggc ggc ggt tca ggc gga 384 Arg Gly Thr Met Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly 115 120 125 ggt ggc tct ggc ggt ggc gga agt
gca ctt gat gtt gtg atg act cag 432 Gly Gly Ser Gly Gly Gly Gly Ser
Ala Leu Asp Val Val Met Thr Gln 130 135 140 tct cct tcc tcc ctg tct
gca tct gtg gga gag aga gtc acc atc aca 480 Ser Pro Ser Ser Leu Ser
Ala Ser Val Gly Glu Arg Val Thr Ile Thr 145 150 155 160 tgc cgg gca
agt cag aac att ttc aac aat tta aat tgg tat caa cag 528 Cys Arg Ala
Ser Gln Asn Ile Phe Asn Asn Leu Asn Trp Tyr Gln Gln 165 170 175 aaa
cca ggg aat gcc cct agc ctc ctg atc tct gat gca tcc agt ttg 576 Lys
Pro Gly Asn Ala Pro Ser Leu Leu Ile Ser Asp Ala Ser Ser Leu 180 185
190 caa agt ggg gcc cca tca agg ttc agt ggc agt gga tct ggg aca gat
624 Gln Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
195 200 205 tat act ctc acc atc agc agt ctg cag cct gaa gat ctt gga
act tac 672 Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Leu Gly
Thr Tyr 210 215 220 tac tgt caa cag agt tac acc atc cct ccg acc ttc
ggc caa ggg aca 720 Tyr Cys Gln Gln Ser Tyr Thr Ile Pro Pro Thr Phe
Gly Gln Gly Thr 225 230 235 240 cga ctg gag att aaa cgt 738 Arg Leu
Glu Ile Lys Arg 245 <210> SEQ ID NO 110 <211> LENGTH:
744 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(744) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0175 scFv protein <400> SEQUENCE: 110 gag gtg cag
ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc 48 Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 tca
gtg aag gtc tcc tgc aag gct tct ggt tac acc ttt acc agc tat 96 Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25
30 ggt atc aac tgg gtg cga cag gcc cct gga cag ggg ctt gag tgg atg
144 Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45 ggg tgg atc agc cct tac aat tat aac aca aac tat gca cag
aag ttg 192 Gly Trp Ile Ser Pro Tyr Asn Tyr Asn Thr Asn Tyr Ala Gln
Lys Leu 50 55 60 cag ggc aga gtc acc atg acc aca gac aca tcc acg
agc aca gcc tac 240 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr
Ser Thr Ala Tyr 65 70 75 80 atg gag ctg agg agc ctg aga tct gac gac
acg gcc gtg tat tat tgt 288 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gag gaa acg ggg agt tat
cat ggg ttt gac tac tgg ggc agg 336 Ala Arg Glu Glu Thr Gly Ser Tyr
His Gly Phe Asp Tyr Trp Gly Arg 100 105 110 gga acc ctg gtc acc gtc
tcg agt gga ggc ggc ggt tca ggc gga ggt 384 Gly Thr Leu Val Thr Val
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 ggc tct ggc ggt
ggc gga agt gca ctt aat ttt atg ctg act cag ccc 432 Gly Ser Gly Gly
Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro 130 135 140 cac tct
gtg tcg gag tct ccg ggg aag acg gta acc atc tcc tgc acc 480 His Ser
Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr 145 150 155
160 gcc agc agt ggc aat att gcc ttc aac tat gtg cag tgg tac cag cag
528 Ala Ser Ser Gly Asn Ile Ala Phe Asn Tyr Val Gln Trp Tyr Gln Gln
165 170 175 cgc ccg ggc agt gcc ccc acc att gtg atc caa gag gat aac
caa aga 576 Arg Pro Gly Ser Ala Pro Thr Ile Val Ile Gln Glu Asp Asn
Gln Arg 180 185 190 ccc tct ggg gtc cct gat cgg ttc tct ggc tcc atc
gac agg tcc tcc 624 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile
Asp Arg Ser Ser 195 200 205 aac tct gcc tcc ctc acc atc tct gga ctg
aag gct gag gac gaa ggt 672 Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu
Lys Ala Glu Asp Glu Gly 210 215 220 gac tat tac tgt cag tct tat gat
aag tac tac cgg atc ttc ggc ggc 720 Asp Tyr Tyr Cys Gln Ser Tyr Asp
Lys Tyr Tyr Arg Ile Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc
gtc cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ
ID NO 111 <211> LENGTH: 729 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(729) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0102 scFv protein
<400> SEQUENCE: 111 gag gtc cag ctg gta cag tct gga ggt gag
gtg aag aag cct ggg gac 48 Glu Val Gln Leu Val Gln Ser Gly Gly Glu
Val Lys Lys Pro Gly Asp 1 5 10 15 tca gtg aag gtc tcc tgc aag gct
tct ggt tac acc ttt tct cac tat 96 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Ser His Tyr 20 25 30 ggt ata agt tgg gtg cga
cag gcc cct gga caa ggg ctt gag tgg atg 144 Gly Ile Ser Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga tgg acc agc
gct tac agt ggt agc aca aac tat gca cag aag ttc 192 Gly Trp Thr Ser
Ala Tyr Ser Gly Ser Thr Asn Tyr Ala Gln Lys Phe 50 55 60 cgg ggc
aga gtc acc atg acc aca gac aca tcc acg ggc aca gca tac 240 Arg Gly
Arg Val Thr Met Thr Thr Asp Thr Ser Thr Gly Thr Ala Tyr 65 70 75 80
atg gaa ctg agg agc ctg aga cct gac gac acg gcc gtc tat tac tgt 288
Met Glu Leu Arg Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 ggg aga gga gac agt tat ggt tcg ata ccc gct gat tac tgg ggc
cgg 336 Gly Arg Gly Asp Ser Tyr Gly Ser Ile Pro Ala Asp Tyr Trp Gly
Arg 100 105 110 gga acc ctg gtc acc gtc tcg agt ggt gga ggc ggt tca
ggc gga ggt 384 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly 115 120 125 ggc agc ggc ggt ggc gga tcg gat gtt gtg atg
act cag tct cca tcc 432 Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met
Thr Gln Ser Pro Ser 130 135 140 tcc ctg tct gca tct cta gga gac aga
gtc acc atc act tgc cgg gca 480 Ser Leu Ser Ala Ser Leu Gly Asp Arg
Val Thr Ile Thr Cys Arg Ala 145 150 155 160 agt cag gac att aca aat
gac tta gcc tgg tat cag cag aaa cca ggg 528 Ser Gln Asp Ile Thr Asn
Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 165 170 175 aaa gcc cct aaa
ctc ctg atc tat ggt gca tcc act ttg caa tat ggg 576 Lys Ala Pro Lys
Leu Leu Ile Tyr Gly Ala Ser Thr Leu Gln Tyr Gly 180 185 190 gtc cca
acc agg ttc agc ggc agt ggg tct ggg aca aac ttc tct ctc 624 Val Pro
Thr Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Ser Leu 195 200 205
act atc agc agc ctg cag cct gag gat ttt gcg act tac ttt tgt caa 672
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln 210
215 220 cag tct cac agt ttc cct ccc act ttc ggc gga ggg acc aag ctg
gag 720 Gln Ser His Ser Phe Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu
Glu 225 230 235 240 atc aaa cgt 729 Ile Lys Arg <210> SEQ ID
NO 112 <211> LENGTH: 762 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(762) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0108 scFv protein
<400> SEQUENCE: 112 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga aat tat tac gat ttt tgg cgt ggt tat caa tca cag ccc
aac 336 Ala Arg Asn Tyr Tyr Asp Phe Trp Arg Gly Tyr Gln Ser Gln Pro
Asn 100 105 110 tac atg gac gtc tgg ggc caa ggg aca atg gtc acc gtc
tcg agt gga 384 Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val
Ser Ser Gly 115 120 125 ggc ggc ggt tca ggc gga ggt ggc tct ggc ggt
ggc gga agt gca cag 432 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Gln 130 135 140 tct gtg ctg acg cag ccg ccc tca gcg
tct ggg acc ccc gag cag agg 480 Ser Val Leu Thr Gln Pro Pro Ser Ala
Ser Gly Thr Pro Glu Gln Arg 145 150 155 160 gtc acc atc tcc tgt tct
gga agc agc tcc aac atc gga tat aat tat 528 Val Thr Ile Ser Cys Ser
Gly Ser Ser Ser Asn Ile Gly Tyr Asn Tyr 165 170 175 gta tac tgg ttc
cag cac ctc ccc gga acg gcc ccc aag ctc ctc atc 576 Val Tyr Trp Phe
Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 180 185 190 tat acg
aat aat ctg cgg ccc tcg ggg gtc cct gac caa ttc tct ggc 624 Tyr Thr
Asn Asn Leu Arg Pro Ser Gly Val Pro Asp Gln Phe Ser Gly 195 200 205
tcc aag tct ggc acc tca gcc tcc ctg gcc atc agt ggg ctc cgg tcc 672
Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser 210
215 220 gag gat gag ggt gat tat tac tgt gca gct tgg gat gac agc ctg
agt 720 Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
Ser 225 230 235 240 ggt cgg gtg ttc ggc gga ggg acc aag gtc acc gtc
cta ggt 762 Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly
245 250 <210> SEQ ID NO 113 <211> LENGTH: 744
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(744) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0112 scFv protein <400> SEQUENCE: 113 gag gtg cag
ctg ttg gag tct ggg gga agc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Ser Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gca aga gag gat cct tgg agc gac
gct ttt gat ttg tgg ggc cga gga 336 Ala Arg Glu Asp Pro Trp Ser Asp
Ala Phe Asp Leu Trp Gly Arg Gly 100 105 110 acc ctg gtc acc gtc tcg
agt gga ggc ggc ggt tca ggc gga ggt ggc 384 Thr Leu Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc
gga agt gca ctt aat ttt atg ctg act cag ccc cac 432 Ser Gly Gly Gly
Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 130 135 140 tct gtg
tcg gag tct ccg ggg aag acg gta acc atc tcc tgc acc ggc 480 Ser Val
Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 145 150 155
160 agc agt ggc agc att gcc agc aac tat gtg cag tgg tac cag cag cgc
528 Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg
165 170 175 ccg ggc agt gcc ccc acc act gtg atc tat gag gat aac caa
aga ccc 576 Pro Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln
Arg Pro 180 185 190 tct ggg gtc cct gat cgc ttc tct ggc tcc atc gac
agc tcc tcc aac 624 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp
Ser Ser Ser Asn 195 200 205 tct gcc tcc ctc acc atc tct gga ctg aag
act gag gac gag gct gac 672 Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys
Thr Glu Asp Glu Ala Asp 210 215 220 tac tac tgt cag tct tat gat agc
agc aat cat tgg gtg ttc ggc gga 720 Tyr Tyr Cys Gln Ser Tyr Asp Ser
Ser Asn His Trp Val Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc
gtc cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ
ID NO 114 <211> LENGTH: 744 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(744) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0117 scFv protein
<400> SEQUENCE: 114 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gcc cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gca aga gat agg ggg tcc cct gat gct ttt gat atc tgg ggc cag
ggg 336 Ala Arg Asp Arg Gly Ser Pro Asp Ala Phe Asp Ile Trp Gly Gln
Gly 100 105 110 aca atg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc
gga ggt ggc 384 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 115 120 125 tct ggc ggt ggc gga agt gca ctt aat ttt atg
ctg act cag ccc cac 432 Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met
Leu Thr Gln Pro His 130 135 140 tct gtg tcg gag tct ccg ggg aag acg
gtg acc atc tcc tgc acc ggc 480 Ser Val Ser Glu Ser Pro Gly Lys Thr
Val Thr Ile Ser Cys Thr Gly 145 150 155 160 agc agt ggc agc att gcc
agc aac tat gtg cag tgg tac cag cag cgc 528 Ser Ser Gly Ser Ile Ala
Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165 170 175 ccg ggc agt gcc
ccc acc act gtg atc tat gag tat agt caa aga ccc 576 Pro Gly Ser Ala
Pro Thr Thr Val Ile Tyr Glu Tyr Ser Gln Arg Pro 180 185 190 tct ggg
gtc cct gat cgg ttc tct ggc tcc atc gac agc tcc tcc aac 624 Ser Gly
Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn 195 200 205
tct gcc tcc ctc acc atc tct ggg ctg aag act gag gac gag gct gac 672
Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp 210
215 220 tac tac tgt cag tct ttt gat acc aac aat cag ggg gtg ttc ggc
gga 720 Tyr Tyr Cys Gln Ser Phe Asp Thr Asn Asn Gln Gly Val Phe Gly
Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt 744 Gly Thr Lys
Leu Thr Val Leu Gly 245 <210> SEQ ID NO 115 <211>
LENGTH: 735 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(735) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0119 scFv protein <400> SEQUENCE: 115 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cca ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aaa ggc atc agc agc agc tgg
acg tta ttt gac tac tgg ggc caa 336 Ala Lys Gly Ile Ser Ser Ser Trp
Thr Leu Phe Asp Tyr Trp Gly Gln 100 105 110 ggg aca atg gtc acc gtc
tcg agt gga ggc ggc ggt tca ggc gga ggt 384 Gly Thr Met Val Thr Val
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 ggc tct ggc ggt
ggc gga agt gca ctt gaa acg aca ctc acg cag tct 432 Gly Ser Gly Gly
Gly Gly Ser Ala Leu Glu Thr Thr Leu Thr Gln Ser 130 135 140 cca gcc
acc ctg tcc ttg tct cca ggg gaa agc gcc acc ctc tcc tgc 480 Pro Ala
Thr Leu Ser Leu Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys 145 150 155
160 agg gcc agt cag agt att gga agt ctc tta gcc tgg tac caa cag aga
528 Arg Ala Ser Gln Ser Ile Gly Ser Leu Leu Ala Trp Tyr Gln Gln Arg
165 170 175 cct ggc cag gct ccc agg ctc gtg atc tcc gat gca tcc aat
agg gcc 576 Pro Gly Gln Ala Pro Arg Leu Val Ile Ser Asp Ala Ser Asn
Arg Ala 180 185 190 tct ggc atc cca gcc agg ttc aga ggc agt ggg tct
gga aca gac ttc 624 Ser Gly Ile Pro Ala Arg Phe Arg Gly Ser Gly Ser
Gly Thr Asp Phe 195 200 205 act ctc acc atc agc agc cta gcg cct gaa
gat ttt gca gtt tat tac 672 Thr Leu Thr Ile Ser Ser Leu Ala Pro Glu
Asp Phe Ala Val Tyr Tyr 210 215 220 tgt cat caa cgt agc atg tgg cct
ctc agt ttc ggc gga ggg acc aag 720 Cys His Gln Arg Ser Met Trp Pro
Leu Ser Phe Gly Gly Gly Thr Lys 225 230 235 240 gtg gaa atc aaa cgt
735 Val Glu Ile Lys Arg 245 <210> SEQ ID NO 116 <211>
LENGTH: 732 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(732) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0121 scFv protein <400> SEQUENCE: 116 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga atc cac aac tgg aac gac
atg ttt gac tac tgg ggc cga ggg 336 Ala Arg Ile His Asn Trp Asn Asp
Met Phe Asp Tyr Trp Gly Arg Gly 100 105 110 aca atg gtc acc gtc tcg
agt gga ggc ggc ggt tca ggc gga ggt ggc 384 Thr Met Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc
gga agt gca ctt gac atc cag ttg acc cag tct cct 432 Ser Gly Gly Gly
Gly Ser Ala Leu Asp Ile Gln Leu Thr Gln Ser Pro 130 135 140 tcc tcc
ctg tct gca tct gtt gga gac aaa gtt acc atc gct tgc cgc 480 Ser Ser
Leu Ser Ala Ser Val Gly Asp Lys Val Thr Ile Ala Cys Arg 145 150 155
160 cca agt cag ggc att agc agt gct tta gcc tgg tat caa cag aaa ccg
528 Pro Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro
165 170 175 gga aaa cct cct aga ctc ctt atc tat gat gtc tcc act ttg
gaa agt 576 Gly Lys Pro Pro Arg Leu Leu Ile Tyr Asp Val Ser Thr Leu
Glu Ser 180 185 190 ggg gtc cca tca agg ttc agc ggc agt gga tct ggg
aca tat ttc act 624 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
Thr Tyr Phe Thr 195 200 205 ctc acc atc agc agt ctg cag cct gag gat
ttt gca act tat tac tgt 672 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
Phe Ala Thr Tyr Tyr Cys 210 215 220 caa caa ttt gat aac tac ccg gtc
acc ttc ggc caa ggg aca cga ctg 720 Gln Gln Phe Asp Asn Tyr Pro Val
Thr Phe Gly Gln Gly Thr Arg Leu 225 230 235 240 gag att aaa cgt 732
Glu Ile Lys Arg <210> SEQ ID NO 117 <211> LENGTH: 741
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(741) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0122 scFv protein <400> SEQUENCE: 117 gag gtg cag
ctg ttg gag tct ggg gaa ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Glu Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aca gat cct tac tat gat agt
agt ggt tat tac ccc ttt agc tac 336 Ala Thr Asp Pro Tyr Tyr Asp Ser
Ser Gly Tyr Tyr Pro Phe Ser Tyr 100 105 110 tgg ggg aag ggg acc acg
gtc acc gtc tcg agt gga ggc ggc ggt tca 384 Trp Gly Lys Gly Thr Thr
Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 ggc gga ggt ggc
tct ggc ggt ggc gga agt gca cag tct gtg ctg act 432 Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr 130 135 140 cag cca
ccc tca gtg tca gtg gcc cca gga cag acg gcc acg att acc 480 Gln Pro
Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Thr 145 150 155
160 tgt ggg gga gac ttt gca act aaa agt gtg aat tgg tac caa cgg aag
528 Cys Gly Gly Asp Phe Ala Thr Lys Ser Val Asn Trp Tyr Gln Arg Lys
165 170 175 ccg ggc cag gcc cct gtg acg gtc atc tat tat tct acc gag
cgg ccc 576 Pro Gly Gln Ala Pro Val Thr Val Ile Tyr Tyr Ser Thr Glu
Arg Pro 180 185 190 ccc gcg atc cct gag cgc ttc tct ggc tcc aac act
ggg tcc acg gcc 624 Pro Ala Ile Pro Glu Arg Phe Ser Gly Ser Asn Thr
Gly Ser Thr Ala 195 200 205 acc ctg acc atc agc agg gtc gaa gcc ggg
gat gag gcc gac tat tat 672 Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
Asp Glu Ala Asp Tyr Tyr 210 215 220 tgt cag gtg tgg gac agt ttt act
gat cat cgg ctg ttc ggc gga ggg 720 Cys Gln Val Trp Asp Ser Phe Thr
Asp His Arg Leu Phe Gly Gly Gly 225 230 235 240 acc aag ctg acc gtc
cta ggt 741 Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
118 <211> LENGTH: 744 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(744) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0123 scFv protein
<400> SEQUENCE: 118 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga tat gct agt ggc ttg ctt gat gct ttt gac ata tgg ggg
cag 336 Ala Arg Tyr Ala Ser Gly Leu Leu Asp Ala Phe Asp Ile Trp Gly
Gln 100 105 110 ggg acc acg gtc acc gtc tcg agt gga ggc ggc ggt tca
ggc gga ggt 384 Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca cag tct gtg
ctg acg cag ccg ccc 432 Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val
Leu Thr Gln Pro Pro 130 135 140 tca gtg tct ggg gcc cca ggg cag agg
gtc acc atc tcc tgc act ggg 480 Ser Val Ser Gly Ala Pro Gly Gln Arg
Val Thr Ile Ser Cys Thr Gly 145 150 155 160 agc agc tcc aac atc ggg
gca ggt aat gat gta aat tgg tac caa caa 528 Ser Ser Ser Asn Ile Gly
Ala Gly Asn Asp Val Asn Trp Tyr Gln Gln 165 170 175 gtt cca gga aga
gcc ccc aaa ctc ctc atc tat ggt acc acc tat cgg 576 Val Pro Gly Arg
Ala Pro Lys Leu Leu Ile Tyr Gly Thr Thr Tyr Arg 180 185 190 ccc tca
ggg gtc cct gac cga ttc tct ggc tcc aag tct ggc acc tca 624 Pro Ser
Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 195 200 205
gcc tcc ctg gcc atc act ggg ctc cag gct gaa gat gag gct gat tat 672
Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr 210
215 220 ttc tgc cag tcc gat gac agc agc ctg agt ggt tcg gtc ttc ggc
gga 720 Phe Cys Gln Ser Asp Asp Ser Ser Leu Ser Gly Ser Val Phe Gly
Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt 744 Gly Thr Lys
Leu Thr Val Leu Gly 245 <210> SEQ ID NO 119 <211>
LENGTH: 762 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(762) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0124 scFv protein <400> SEQUENCE: 119 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 ccc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Pro
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gtg aaa gat acg gag ttt tat tac
gat ttt tgg agt aat gac ggg ggc 336 Val Lys Asp Thr Glu Phe Tyr Tyr
Asp Phe Trp Ser Asn Asp Gly Gly 100 105 110 tgg ttc gac acc tgg ggc
cgg ggg aca atg gtc acc gtc tcg agt gga 384 Trp Phe Asp Thr Trp Gly
Arg Gly Thr Met Val Thr Val Ser Ser Gly 115 120 125 ggc ggc ggt tca
ggc gga ggt ggc tct ggc ggt ggc gga agt gca cag 432 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln 130 135 140 gct gtg
ctg act cag ccg tcc tca acg tct ggg tcc ccc ggg cag agg 480 Ala Val
Leu Thr Gln Pro Ser Ser Thr Ser Gly Ser Pro Gly Gln Arg 145 150 155
160 gtc acc atc tct tgt tct gga agc aac tcc aac atc gga agt aat tat
528 Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn Tyr
165 170 175 gtc tac tgg tac cag caa ctc ccg gga acg gcc ccc aaa ctc
ctc att 576 Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
Leu Ile 180 185 190 tat agg aat aat cag cgg ccc tca ggg gtc cct gac
cga ttc tct ggc 624 Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp
Arg Phe Ser Gly 195 200 205 tcc aag tct ggc acc tca gcc tcc ctg gcc
atc agt ggg ctc cgg tcc 672 Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala
Ile Ser Gly Leu Arg Ser 210 215 220 ggc gat gag ggt gat tat cac tgt
gca acg tgg gat gac agg ctg tat 720 Gly Asp Glu Gly Asp Tyr His Cys
Ala Thr Trp Asp Asp Arg Leu Tyr 225 230 235 240 ggt tgg gtg ttc ggc
gga ggg acc aag gtc acc gtc cta ggt 762 Gly Trp Val Phe Gly Gly Gly
Thr Lys Val Thr Val Leu Gly 245 250 <210> SEQ ID NO 120
<211> LENGTH: 735 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(735) <223> OTHER INFORMATION:
Polynucleotide encoding RGD0130 scFv protein <400> SEQUENCE:
120 gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cca ggg ggg
48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc
agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg
ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 tca gct att agt ggt agt ggt ggt agc aca
tac tac gca gac tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr
Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga
gac aat tcc aag aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg
aga gcc gag gac acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aaa ggc atc
agc agc agc tgg acg tta ttt gac tac tgg ggc caa 336 Ala Lys Gly Ile
Ser Ser Ser Trp Thr Leu Phe Asp Tyr Trp Gly Gln 100 105 110 ggg aca
atg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc gga ggt 384 Gly Thr
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125
ggc tct ggc ggt ggc gga agt gca ctt gaa acg aca ctc acg cag tct 432
Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Thr Leu Thr Gln Ser 130
135 140 cca gcc acc ctg tcc ttg tct cca ggg gaa agc gcc acc ctc tcc
tgc 480 Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Ser Ala Thr Leu Ser
Cys 145 150 155 160 agg gcc agt cag agt att gga agt ctc tta gcc tgg
tac caa cag aga 528 Arg Ala Ser Gln Ser Ile Gly Ser Leu Leu Ala Trp
Tyr Gln Gln Arg 165 170 175 cct ggc cag gct ccc agg ctc gtg atc tcc
gat gca tcc aat agg gcc 576 Pro Gly Gln Ala Pro Arg Leu Val Ile Ser
Asp Ala Ser Asn Arg Ala 180 185 190 tct ggc atc cca gcc agg ttc aga
ggc agt ggg tct gga aca gac ttc 624 Ser Gly Ile Pro Ala Arg Phe Arg
Gly Ser Gly Ser Gly Thr Asp Phe 195 200 205 act ctc acc atc agc agc
cta gcg cct gaa gat ttt gca gtt tat tac 672 Thr Leu Thr Ile Ser Ser
Leu Ala Pro Glu Asp Phe Ala Val Tyr Tyr 210 215 220 tgt caa caa cgt
agc atg tgg cct ctc agt ttc ggc gga ggg acc aag 720 Cys Gln Gln Arg
Ser Met Trp Pro Leu Ser Phe Gly Gly Gly Thr Lys 225 230 235 240 gtg
gaa atc aaa cgt 735 Val Glu Ile Lys Arg 245 <210> SEQ ID NO
121 <211> LENGTH: 747 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(747) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0135 scFv protein
<400> SEQUENCE: 121 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga tat gct agt ggc ttg gtt gat gct ttt gac atg tgg ggc
cgg 336 Ala Arg Tyr Ala Ser Gly Leu Val Asp Ala Phe Asp Met Trp Gly
Arg 100 105 110 ggg aca atg gtc acc gtc tcg agt gga ggc ggc ggt tca
ggc gga ggt 384 Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca cag gct gtg
ctg act cag ccg tcc 432 Gly Ser Gly Gly Gly Gly Ser Ala Gln Ala Val
Leu Thr Gln Pro Ser 130 135 140 tca gtg tcc ggg gcc cca ggg cag agg
gtc acc atc tcc tgc act ggg 480 Ser Val Ser Gly Ala Pro Gly Gln Arg
Val Thr Ile Ser Cys Thr Gly 145 150 155 160 cgc agc tcc aac atc ggg
gca ggt tat gat gtt aat tgg tac cag cag 528 Arg Ser Ser Asn Ile Gly
Ala Gly Tyr Asp Val Asn Trp Tyr Gln Gln 165 170 175 ctt cca gga gca
gcc ccc aaa ctc ctc atc tat gat aac aac tat cgg 576 Leu Pro Gly Ala
Ala Pro Lys Leu Leu Ile Tyr Asp Asn Asn Tyr Arg 180 185 190 ccc tcg
ggg gtc cct gac cga ttc tct ggc tcc aag tct ggc acc tca 624 Pro Ser
Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 195 200 205
gcc tcc ctg gcc ata act ggg ctc cag gct gac gat gag gct gtt tat 672
Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Asp Asp Glu Ala Val Tyr 210
215 220 tac tgc cag tct tat gac agc agc ctg agt ggt tca gag gtc ttc
ggc 720 Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Glu Val Phe
Gly 225 230 235 240 gga ggg acc aag gtc acc gtc cta ggt 747 Gly Gly
Thr Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO 122
<211> LENGTH: 753 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(753) <223> OTHER INFORMATION:
Polynucleotide encoding RGD0136 scFv protein <400> SEQUENCE:
122 gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg
48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc
agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg
ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 tca gct att agt ggt agt ggt ggt agc aca
tac tac gca gac tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr
Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga
gac aat tcc aag aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg
aga gcc gag gac gcg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95 gcg aaa gat tcc
ctg gga cta tgg ttc gga ctc gga cac ttt gag aac 336 Ala Lys Asp Ser
Leu Gly Leu Trp Phe Gly Leu Gly His Phe Glu Asn 100 105 110 tgg ggc
cgg ggc acc ctg gtc acc gtc tcg agt gga ggc ggc ggt tca 384 Trp Gly
Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125
ggc gga ggt ggc tct ggc ggt ggc gga agt gca ctt aat ttt atg ctg 432
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu 130
135 140 act cag ccc cac tct gtg tcg gag tct ccg ggt aag aca gta act
ctc 480 Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr
Leu 145 150 155 160 tcc tgc acc cgc tcc agt ggc agc att tca ttc gac
tat gtg cag tgg 528 Ser Cys Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp
Tyr Val Gln Trp 165 170 175 tat caa cag cgg ccg ggc agc tcc ccc att
ctt gtg atc ttt gaa gat 576 Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile
Leu Val Ile Phe Glu Asp 180 185 190 gac caa aga ccc tct ggg gtc cct
gat cga ttc tct ggc tcc atc gac 624 Asp Gln Arg Pro Ser Gly Val Pro
Asp Arg Phe Ser Gly Ser Ile Asp 195 200 205 agt acc tcc aac tct gcc
tcc ctc acc atc tct ggc ctg cag agt gag 672 Ser Thr Ser Asn Ser Ala
Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu 210 215 220 gac gag ggt gac
tac tat tgt cag act tat gat gac aac cgt cag gtg 720 Asp Glu Gly Asp
Tyr Tyr Cys Gln Thr Tyr Asp Asp Asn Arg Gln Val 225 230 235 240 ttc
ggc gga ggg acc aag ctg acc gtc cta ggt 753 Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu Gly 245 250 <210> SEQ ID NO 123 <211>
LENGTH: 744 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(744) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0141 scFv protein <400> SEQUENCE: 123 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gac tcc ctc tac ggt gac
ctc gaa tac ttc cag cac tgg ggg 336 Ala Arg Asp Ser Leu Tyr Gly Asp
Leu Glu Tyr Phe Gln His Trp Gly 100 105 110 cga ggg acc acg gtc acc
gtc tcg agt gga ggc ggc ggt tca ggc gga 384 Arg Gly Thr Thr Val Thr
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 ggt ggc tct ggc
ggt ggc gga agt gca cag tct gtg ctg act cag cca 432 Gly Gly Ser Gly
Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro 130 135 140 tcc tca
gcg tct ggg aac ccc gga cag agg gtc acc att tct tgt tct 480 Ser Ser
Ala Ser Gly Asn Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 145 150 155
160 gga agc agc tcc aac atc ggg gat aat cct gtg gac tgg tat cag cat
528 Gly Ser Ser Ser Asn Ile Gly Asp Asn Pro Val Asp Trp Tyr Gln His
165 170 175 gtc cca gga agg gcc ccc aaa ctc ctc atc ttt agg gat aat
cag cgg 576 Val Pro Gly Arg Ala Pro Lys Leu Leu Ile Phe Arg Asp Asn
Gln Arg 180 185 190 ccc tca ggg gtc cct gac cga ttc tct ggc acc aag
tct ggc acc tca 624 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Thr Lys
Ser Gly Thr Ser 195 200 205 gcc tcc ctg gcc atc agt ggc ctc cag tct
gag gat gag gct gat tat 672 Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser
Glu Asp Glu Ala Asp Tyr 210 215 220 tac tgt gaa gca tgg gat gac agc
ctg gat agt ccg gtg ttc ggc gga 720 Tyr Cys Glu Ala Trp Asp Asp Ser
Leu Asp Ser Pro Val Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc
gtc cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ
ID NO 124 <211> LENGTH: 759 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(759) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0143 scFv protein
<400> SEQUENCE: 124 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gcc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Ala Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga cat cgg ggg att aca atg tat gga gtg ctc cgt cct ggc
gat 336 Ala Arg His Arg Gly Ile Thr Met Tyr Gly Val Leu Arg Pro Gly
Asp 100 105 110 atg gac gtc tgg ggc cga gga acc ctg gtc acc gtc tcg
agt gga ggc 384 Met Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser
Ser Gly Gly 115 120 125 ggc ggt tca ggc gga ggt ggc tct ggc ggt ggc
gga agt gca cag gct 432 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Ala Gln Ala 130 135 140 gtg ctg act cag ccg tcc tca gcg tct
gcg acc ccc ggg cag agg gtc 480 Val Leu Thr Gln Pro Ser Ser Ala Ser
Ala Thr Pro Gly Gln Arg Val 145 150 155 160 acc atc tct tgt tct gga
agc agc tcc aac atc gga agt aat agt gta 528 Thr Ile Ser Cys Ser Gly
Ser Ser Ser Asn Ile Gly Ser Asn Ser Val 165 170 175 aac tgg tac cag
cac ctc cca gga acg gcc ccc aaa ctc ctc atc tat 576 Asn Trp Tyr Gln
His Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 180 185 190 act aat
gat cag cgg ccc tca ggg gtc cct gac cga ttc tct ggc tcc 624 Thr Asn
Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 195 200 205
aag tct ggc acc tca gcc tcc ctg gcc atc agt ggg ctc cag tct gag 672
Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu 210
215 220 gat gag gct gat tat tac tgt gca gca tgg gat gac acc ctg act
ggt 720 Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Thr Leu Thr
Gly 225 230 235 240 ccg gtc ttc ggc gga ggg acc aag ctg acc gtc cta
ggt 759 Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250
<210> SEQ ID NO 125 <211> LENGTH: 726 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(726)
<223> OTHER INFORMATION: Polynucleotide encoding RGD0145 scFv
protein <400> SEQUENCE: 125 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga aga tac cga tac ttt gac aac tgg ggc cag
ggg aca atg gtc 336 Ala Arg Arg Tyr Arg Tyr Phe Asp Asn Trp Gly Gln
Gly Thr Met Val 100 105 110 acc gtc tcg agt gga ggc ggc ggt tca ggc
gga ggt ggc tct ggc ggt 384 Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly 115 120 125 ggc gga agt gca ctt tct tct gag
ctg act cag gac cct gct gtg tct 432 Gly Gly Ser Ala Leu Ser Ser Glu
Leu Thr Gln Asp Pro Ala Val Ser 130 135 140 gtg gcc ttg gga cag aca
gtc agg atc aca tgc caa gga gac agc ctc 480 Val Ala Leu Gly Gln Thr
Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 145 150 155 160 aga acc tat
tat gca agc tgg tac cag cag aag cca gga cag gcc cct 528 Arg Thr Tyr
Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 165 170 175 gtt
ctt gtc ttc tat ggt aaa aaa aat cgg ccc tca ggg atc cca gac 576 Val
Leu Val Phe Tyr Gly Lys Lys Asn Arg Pro Ser Gly Ile Pro Asp 180 185
190 cga ttc tct ggc tcc agc tca gga aac aca tct tcc ttg acc atc act
624 Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ser Ser Leu Thr Ile Thr
195 200 205 ggg gct cag gca gaa gat gac gct gac tat tac tgt aac tcc
cgg gac 672 Gly Ala Gln Ala Glu Asp Asp Ala Asp Tyr Tyr Cys Asn Ser
Arg Asp 210 215 220 agc agt ggt aac cat ctg gta ttc ggc gga ggg acc
aag ctg acc gtc 720 Ser Ser Gly Asn His Leu Val Phe Gly Gly Gly Thr
Lys Leu Thr Val 225 230 235 240 cta ggt 726 Leu Gly <210> SEQ
ID NO 126 <211> LENGTH: 753 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(753) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0153 scFv protein
<400> SEQUENCE: 126 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt acc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga ttg cgg ggt agt acc agg tgg gaa gac ttc tat tac ttt
gac 336 Ala Arg Leu Arg Gly Ser Thr Arg Trp Glu Asp Phe Tyr Tyr Phe
Asp 100 105 110 tac tgg ggc aaa ggg aca atg gtc acc gtc tcg agt gga
ggc ggc ggt 384 Tyr Trp Gly Lys Gly Thr Met Val Thr Val Ser Ser Gly
Gly Gly Gly 115 120 125 tca ggc gga ggt ggc tct ggc ggt ggc gga agt
gca cag act gtg gtg 432 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Gln Thr Val Val 130 135 140 atc cag gag cca tct ttc tca gtg tcc
cct gga ggg aca gtc aca ctc 480 Ile Gln Glu Pro Ser Phe Ser Val Ser
Pro Gly Gly Thr Val Thr Leu 145 150 155 160 act tgt ggc ctg agc tct
ggc tca gtc tct act act tac tac ccc agc 528 Thr Cys Gly Leu Ser Ser
Gly Ser Val Ser Thr Thr Tyr Tyr Pro Ser 165 170 175 tgg tac cag cag
acc cca ggc cag gct cca cgc acg ctc atc tac aac 576 Trp Tyr Gln Gln
Thr Pro Gly Gln Ala Pro Arg Thr Leu Ile Tyr Asn 180 185 190 aca aac
act cgc tct tct ggg gtc cct gat cgc ttc tct ggc tcc atc 624 Thr Asn
Thr Arg Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile 195 200 205
ctt ggg aac aaa gct gcc ctc acc atc acg ggg gcc cag gca gat gat 672
Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp 210
215 220 gaa tct gat tat tac tgt gtg ctg tat ctg ggt agt ggc att tgg
gtg 720 Glu Ser Asp Tyr Tyr Cys Val Leu Tyr Leu Gly Ser Gly Ile Trp
Val 225 230 235 240 ttc ggc gga ggg acc aag ctg acc gtc cta ggt 753
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250 <210> SEQ
ID NO 127 <211> LENGTH: 741 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(741) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0154 scFv protein
<400> SEQUENCE: 127 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gtg cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tcg gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aca gat cct tac tat gat agt agt ggt tat tac ccc ttt agc
tac 336 Ala Thr Asp Pro Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro Phe Ser
Tyr 100 105 110 tgg ggc cgg ggg aca atg gtc acc gtc tcg agt gga ggc
ggc ggt tca 384 Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly
Gly Gly Ser 115 120 125 ggc gga ggt ggc tct ggc ggt ggc gga agt gca
cag tct gtc gtg acg 432 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
Gln Ser Val Val Thr 130 135 140 cag ccg ccc tca gtg tca gtg gcc cca
gga aag acg gcc acg att acc 480 Gln Pro Pro Ser Val Ser Val Ala Pro
Gly Lys Thr Ala Thr Ile Thr 145 150 155 160 tgt ggg gga gac ttt gca
act aaa agt gtg aat tgg tac caa cgg aag 528 Cys Gly Gly Asp Phe Ala
Thr Lys Ser Val Asn Trp Tyr Gln Arg Lys 165 170 175 ccg ggc cag gcc
cct gtg acg gtc atc tat tat aat acc gag cgg ccc 576 Pro Gly Gln Ala
Pro Val Thr Val Ile Tyr Tyr Asn Thr Glu Arg Pro 180 185 190 cca gcg
atc cct gag cgc ttc tct ggc tcc aac act ggg tcc acg gcc 624 Pro Ala
Ile Pro Glu Arg Phe Ser Gly Ser Asn Thr Gly Ser Thr Ala 195 200 205
acc ctg acc atc agc agg gtc gaa gcc ggg gat gag gcc gac tat tat 672
Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 210
215 220 tgt cag gtg tgg gac agt ttt act gat cat cgg ctg ttc ggc gga
ggg 720 Cys Gln Val Trp Asp Ser Phe Thr Asp His Arg Leu Phe Gly Gly
Gly 225 230 235 240 acc aag gtc acc gtc cta ggt 741 Thr Lys Val Thr
Val Leu Gly 245 <210> SEQ ID NO 128 <211> LENGTH: 753
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(753) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0169 scFv protein <400> SEQUENCE: 128 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gat aga gtg agg cgc gtt
ccc ttt ggt tcg ggg agc tat tta 336 Ala Arg Asp Arg Val Arg Arg Val
Pro Phe Gly Ser Gly Ser Tyr Leu 100 105 110 aac ccc ttt gac tgg ggc
caa ggg aca atg gtc acc gtc tcg agt gga 384 Asn Pro Phe Asp Trp Gly
Gln Gly Thr Met Val Thr Val Ser Ser Gly 115 120 125 ggc ggc ggt tca
ggc gga ggt ggc tct ggc ggt ggc gga agt gca ctt 432 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu 130 135 140 tcc tat
gag ctg act cag cca ccc tca gtg tcc gtg tcc cca gga caa 480 Ser Tyr
Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 145 150 155
160 aca gcc agc atc acc tgt act ggg gat aaa ttg gcg gag aaa tat gtt
528 Thr Ala Ser Ile Thr Cys Thr Gly Asp Lys Leu Ala Glu Lys Tyr Val
165 170 175 tct tgg tat cag cag aag aca ggc cgg tcc cct gtg ttg gtc
atc tat 576 Ser Trp Tyr Gln Gln Lys Thr Gly Arg Ser Pro Val Leu Val
Ile Tyr 180 185 190 caa gat gac agg cgg ccc tca gag atc cct gag cga
ttc tct ggc tcc 624 Gln Asp Asp Arg Arg Pro Ser Glu Ile Pro Glu Arg
Phe Ser Gly Ser 195 200 205 aac tct ggg aac aca gcc act ttg acc gtc
agc ggg gcc cag tct atg 672 Asn Ser Gly Asn Thr Ala Thr Leu Thr Val
Ser Gly Ala Gln Ser Met 210 215 220 gat gag gct gac tac tac tgt caa
gta tgg gac agc aac act gtg ata 720 Asp Glu Ala Asp Tyr Tyr Cys Gln
Val Trp Asp Ser Asn Thr Val Ile 225 230 235 240 ttc ggc gga ggg acc
aag gtc acc gtc cta ggt 753 Phe Gly Gly Gly Thr Lys Val Thr Val Leu
Gly 245 250 <210> SEQ ID NO 129 <211> LENGTH: 747
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(747) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0170 scFv protein <400> SEQUENCE: 129 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga acc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga cag cag ccc ttc acc gac
gcg ttc gac att tgg ggc caa ggg 336 Ala Arg Gln Gln Pro Phe Thr Asp
Ala Phe Asp Ile Trp Gly Gln Gly 100 105 110 aca atg gtc acc gtc tcg
agt gga ggc ggc ggt tca ggc gga ggt ggc 384 Thr Met Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc
gga agt gca ctt aat ttt atg ctg act cag ccc cac 432 Ser Gly Gly Gly
Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 130 135 140 tct gtg
tcg gag tct ccg ggg aag acg gta acc atc tcc tgc acc ggc 480 Ser Val
Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 145 150 155
160 agc agt ggc aac att gcc aac aac tat gtg cag tgg ttc caa cag cgc
528 Ser Ser Gly Asn Ile Ala Asn Asn Tyr Val Gln Trp Phe Gln Gln Arg
165 170 175 ccg ggc agt gcc ccc acc act gtg atc tat gag gat aac caa
aga ccc 576 Pro Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln
Arg Pro 180 185 190 tct ggg gtc cct gat cgg ttc tct ggc tcc atc gac
agc tcc tcc aac 624 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp
Ser Ser Ser Asn 195 200 205 tct gcc tcc ctc acc atc tct gga ctg aag
act gag gac gag gct gac 672 Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys
Thr Glu Asp Glu Ala Asp 210 215 220 tac tac tgt cag tct tat gat agc
agc aat ctt tat gtg gta ttc ggc 720 Tyr Tyr Cys Gln Ser Tyr Asp Ser
Ser Asn Leu Tyr Val Val Phe Gly 225 230 235 240 gga ggg acc aag gtc
acc gtc cta ggt 747 Gly Gly Thr Lys Val Thr Val Leu Gly 245
<210> SEQ ID NO 130 <211> LENGTH: 744 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(744)
<223> OTHER INFORMATION: Polynucleotide encoding RGD0180 scFv
protein <400> SEQUENCE: 130 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc gga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga cta ggt aac tgg aac gac gtc ttt gac tac
tgg ggc caa ggg 336 Ala Arg Leu Gly Asn Trp Asn Asp Val Phe Asp Tyr
Trp Gly Gln Gly 100 105 110 aca atg gtc acc gtc tcg agt gga ggc ggc
ggt tca ggc gga ggt ggc 384 Thr Met Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc gga agt gca ctt
aat ttt atg ctg act cag ccc cac 432 Ser Gly Gly Gly Gly Ser Ala Leu
Asn Phe Met Leu Thr Gln Pro His 130 135 140 tct gtg tcg gag tct ccg
ggg aag acg gta acc atc tcc tgc acc cgc 480 Ser Val Ser Glu Ser Pro
Gly Lys Thr Val Thr Ile Ser Cys Thr Arg 145 150 155 160 agc agt ggc
agc att gcc aac aac tat gtg cag tgg tac cag cag cgc 528 Ser Ser Gly
Ser Ile Ala Asn Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165 170 175 ccg
ggc agt gcc ccc acc act gtg atc ttt gag gat gac caa aga ccc 576 Pro
Gly Ser Ala Pro Thr Thr Val Ile Phe Glu Asp Asp Gln Arg Pro 180 185
190 tct ggg gtc cct gat cgg ttc tct ggc tcc atc gac cgc tcc tcc aac
624 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn
195 200 205 tct gcc tcc ctc acc atc tct gga ctg aag act gac gac gag
gct gac 672 Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Asp Asp Glu
Ala Asp 210 215 220 tac tac tgt cag tct aat gat ggc acc aat cct tgg
gtg ttc ggc gga 720 Tyr Tyr Cys Gln Ser Asn Asp Gly Thr Asn Pro Trp
Val Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt 744
Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 131
<211> LENGTH: 744 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(744) <223> OTHER INFORMATION:
Polynucleotide encoding RGD0182 scFv protein <400> SEQUENCE:
131 gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg
48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc
agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg
ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 tca gct att agt ggt agt ggt ggt agc aca
tac tac gca gac tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr
Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga
gac aat tcc aag aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg
aga gcc gag gac acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gca aga gag gat
cct tgg agt gac gct ttt gat ttg tgg ggc aaa ggg 336 Ala Arg Glu Asp
Pro Trp Ser Asp Ala Phe Asp Leu Trp Gly Lys Gly 100 105 110 aca atg
gtc acc gtc tcg agt gga ggc ggc ggt tca ggc gga ggt ggc 384 Thr Met
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125
tct ggc ggt ggc gga agt gca ctt aat ttt atg ctg act cag ccc cac 432
Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 130
135 140 tct gtg tcg gag tct ccg ggg aag acg gtc acc atc tcc tgc acc
ggc 480 Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr
Gly 145 150 155 160 agc agt ggc agc att gcc aac aac tat gtg cag tgg
tac caa cag cgc 528 Ser Ser Gly Ser Ile Ala Asn Asn Tyr Val Gln Trp
Tyr Gln Gln Arg 165 170 175 ccg ggc agt gcc ccc acc act gtg att tat
gag gat aac caa aga ccc 576 Pro Gly Ser Ala Pro Thr Thr Val Ile Tyr
Glu Asp Asn Gln Arg Pro 180 185 190 tct gga gtc cct gat cgg ttc tct
gcc tcc atc gac agg tcc tcc aac 624 Ser Gly Val Pro Asp Arg Phe Ser
Ala Ser Ile Asp Arg Ser Ser Asn 195 200 205 tct gcc tcc ctc acc atc
tct gga ctg atg act gag gac gag gct gac 672 Ser Ala Ser Leu Thr Ile
Ser Gly Leu Met Thr Glu Asp Glu Ala Asp 210 215 220 tac tac tgt cag
tct tat gat agc aac aat cat tgg gtg ttc ggc gga 720 Tyr Tyr Cys Gln
Ser Tyr Asp Ser Asn Asn His Trp Val Phe Gly Gly 225 230 235 240 ggg
acc aag ctg acc gtc cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 132 <211> LENGTH: 735 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(735)
<223> OTHER INFORMATION: Polynucleotide encoding RGD0183 scFv
protein <400> SEQUENCE: 132 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg agg gga tcc gat agc agc aac tgg ttc ttt gac
tac tgg ggc cag 336 Ala Arg Gly Ser Asp Ser Ser Asn Trp Phe Phe Asp
Tyr Trp Gly Gln 100 105 110 ggg aca atg gtc acc gtc tcg agt gga ggc
ggc ggt tca ggc gga ggt 384 Gly Thr Met Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca
ctt gat gtt gtg atg act cag tct 432 Gly Ser Gly Gly Gly Gly Ser Ala
Leu Asp Val Val Met Thr Gln Ser 130 135 140 cca gcc acc ctg tct ttg
tct cca ggg gaa aga gcc acc ctc tcc tgc 480 Pro Ala Thr Leu Ser Leu
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 145 150 155 160 agg gcc agt
cag agt gtt agc agc ttc tta gcc tgg tac caa cag aaa 528 Arg Ala Ser
Gln Ser Val Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys 165 170 175 cct
ggc cag gct ccc agg ctc ctc atg tat gat gca tcc aac agg gcc 576 Pro
Gly Gln Ala Pro Arg Leu Leu Met Tyr Asp Ala Ser Asn Arg Ala 180 185
190 act ggc atc cca gcc agg ttc agt ggc agt ggg tct ggg aca gac ttc
624 Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
195 200 205 act ctc acc atc agc agc cta gag cct gaa gat ttt gca gtt
tat tac 672 Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val
Tyr Tyr 210 215 220 tgt cag cag cgt agc aac tgg ccg atc acc ttc ggc
caa ggg aca cga 720 Cys Gln Gln Arg Ser Asn Trp Pro Ile Thr Phe Gly
Gln Gly Thr Arg 225 230 235 240 ctg gag att aaa cgt 735 Leu Glu Ile
Lys Arg 245 <210> SEQ ID NO 133 <211> LENGTH: 726
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(726) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0193 scFv protein <400> SEQUENCE: 133 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gca aga agg cgg tat gcg ttg gat
tat tgg ggc cgg ggc acc ctg gtc 336 Ala Arg Arg Arg Tyr Ala Leu Asp
Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110 acc gtc tcg agt gga ggc
ggc ggt tca ggc gga ggt ggc tct ggc ggt 384 Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 ggc gga agt gca
ctt tct tct gag ctg act cag gac cct gct gtg tct 432 Gly Gly Ser Ala
Leu Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser 130 135 140 gtg gcc
ttg gga cag aca gtc agg atc aca tgc cag gga gac agc ctc 480 Val Ala
Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 145 150 155
160 aga aac tat tat cca agc tgg tac cag cag agc cca gga cag gcc cct
528 Arg Asn Tyr Tyr Pro Ser Trp Tyr Gln Gln Ser Pro Gly Gln Ala Pro
165 170 175 gta ctt gtc atc tat ggt aaa aac aag cgg ccc tca ggg atc
cca gac 576 Val Leu Val Ile Tyr Gly Lys Asn Lys Arg Pro Ser Gly Ile
Pro Asp 180 185 190 cga ttc tct ggc tcc agc tca gga aac aca gct tcc
ttg acc atc act 624 Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser
Leu Thr Ile Thr 195 200 205 ggg gct cag gcg gaa gat gag gct gac tat
tac tgt aac tcc cgg gac 672 Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Asn Ser Arg Asp 210 215 220 agc agt ggt aac cat cta cta ttc
ggc gga ggg acc aag ctg acc gtc 720 Ser Ser Gly Asn His Leu Leu Phe
Gly Gly Gly Thr Lys Leu Thr Val 225 230 235 240 cta ggt 726 Leu Gly
<210> SEQ ID NO 134 <211> LENGTH: 741 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(741)
<223> OTHER INFORMATION: Polynucleotide encoding RGD0195 scFv
protein <400> SEQUENCE: 134 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aca gat cct tac tat gat agt agt ggt tat tac
ccc ttt agc tac 336 Ala Thr Asp Pro Tyr Tyr Asp Ser Ser Gly Tyr Tyr
Pro Phe Ser Tyr 100 105 110 tgg ggc caa ggg aca atg gtc acc gtc tcg
agt gga ggc ggc ggt tca 384 Trp Gly Gln Gly Thr Met Val Thr Val Ser
Ser Gly Gly Gly Gly Ser 115 120 125 ggc gga ggt ggc tct ggc ggt ggc
gga agt gca cag tct gtg ctg act 432 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Ala Gln Ser Val Leu Thr 130 135 140 cag cca ccc tca gtg tca
gtg gcc cca gga aag acg gcc aca att acc 480 Gln Pro Pro Ser Val Ser
Val Ala Pro Gly Lys Thr Ala Thr Ile Thr 145 150 155 160 tgt ggg gga
gac ttt gca act aaa aat gtg aat tgg tac caa cgg aag 528 Cys Gly Gly
Asp Phe Ala Thr Lys Asn Val Asn Trp Tyr Gln Arg Lys 165 170 175 ccg
ggc cag gcc cct gtg acg gtc atc tat tat aat acc gag cgg ccc 576 Pro
Gly Gln Ala Pro Val Thr Val Ile Tyr Tyr Asn Thr Glu Arg Pro 180 185
190 tca gcg atc cct gag cgc ttc tct ggc tcc aac act ggg tcc acg gcc
624 Ser Ala Ile Pro Glu Arg Phe Ser Gly Ser Asn Thr Gly Ser Thr Ala
195 200 205 acc ctg acc atc agc agg gtc gaa gcc ggg gat gag gcc gac
tat tat 672 Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp
Tyr Tyr 210 215 220 tgt cag gtg tgg gat agt ttt act gat cat cgg ctg
ttc ggc gga ggg 720 Cys Gln Val Trp Asp Ser Phe Thr Asp His Arg Leu
Phe Gly Gly Gly 225 230 235 240 acc aag ctg act gtc cta ggt 741 Thr
Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 135 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 135 caggtgcagc tggtgcagtc tgg 23 <210> SEQ ID NO
136 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 136 caggtcaact taagggagtc tgg 23
<210> SEQ ID NO 137 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 137 gaggtgcagc tggtggagtc tgg
23 <210> SEQ ID NO 138 <211> LENGTH: 23 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 138 caggtgcagc
tgcaggagtc ggg 23 <210> SEQ ID NO 139 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 139
gaggtgcagc tgttgcagtc tgc 23 <210> SEQ ID NO 140 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 140 caggtacagc tgcagcagtc agg 23 <210> SEQ ID NO
141 <211> LENGTH: 24 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 141 tgaggagacg gtgaccaggg tgcc 24
<210> SEQ ID NO 142 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 142 tgaagagacg gtgaccattg tccc
24 <210> SEQ ID NO 143 <211> LENGTH: 24 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 143 tgaggagacg
gtgaccaggg ttcc 24 <210> SEQ ID NO 144 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 144
tgaggagacg gtgaccgtgg tccc 24 <210> SEQ ID NO 145 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 145 gacatccaga tgacccagtc tcc 23 <210> SEQ ID NO
146 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 146 gatgttgtga tgactcagtc tcc 23
<210> SEQ ID NO 147 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 147 gatattgtga tgactcagtc tcc
23 <210> SEQ ID NO 148 <211> LENGTH: 23 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 148 gaaattgtgt
tgacgcagtc tcc 23 <210> SEQ ID NO 149 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 149
gacatcgtga tgacccagtc tcc 23 <210> SEQ ID NO 150 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 150 gaaacgacac tcacgcagtc tcc 23 <210> SEQ ID NO
151 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 151 gaaattgtgc tgactcagtc tcc 23
<210> SEQ ID NO 152 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 152 cagtctgtgt tgacgcagcc gcc
23 <210> SEQ ID NO 153 <211> LENGTH: 23 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 153 cagtctgccc
tgactcagcc tgc 23 <210> SEQ ID NO 154 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 154
tcctatgtgc tgactcagcc acc 23 <210> SEQ ID NO 155 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 155 tcttctgagc tgactcagga ccc 23 <210> SEQ ID NO
156 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 156 cacgttatac tgactcaacc gcc 23
<210> SEQ ID NO 157 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 157 caggctgtgc tcactcagcc gtc
23 <210> SEQ ID NO 158 <211> LENGTH: 23 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 158 aattttatgc
tgactcagcc cca 23 <210> SEQ ID NO 159 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 159
acgtttgatt tccaccttgg tccc 24 <210> SEQ ID NO 160 <211>
LENGTH: 24 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 160 acgtttgatc tccagcttgg tccc 24 <210> SEQ ID NO
161 <211> LENGTH: 24 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 161 acgtttgata tccactttgg tccc 24
<210> SEQ ID NO 162 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 162 acgtttgatc tccaccttgg tccc
24 <210> SEQ ID NO 163 <211> LENGTH: 24 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 163 acgtttaatc
tccagtcgtg tccc 24 <210> SEQ ID NO 164 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 164
cagtctgtgt tgacgcagcc gcc 23 <210> SEQ ID NO 165 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 165 cagtctgccc tgactcagcc tgc 23 <210> SEQ ID NO
166 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 166 tcctatgtgc tgactcagcc acc 23
<210> SEQ ID NO 167 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 167 tcttctgagc tgactcagga ccc
23 <210> SEQ ID NO 168 <211> LENGTH: 23 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 168 cacgttatac
tgactcaacc gcc 23 <210> SEQ ID NO 169 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 169
caggctgtgc tcactcagcc gtc 23 <210> SEQ ID NO 170 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 170 aattttatgc tgactcagcc cca 23 <210> SEQ ID NO
171 <211> LENGTH: 1114 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 171 gcacgaggcc
aaacagattt gcagatcaag gagaacccag gagtttcaaa gaagcgctag 60
taaggtctct gagatccttg cactagctac atcctcaggg taggaggaag atggcttcca
120 gaagcatgcg gctgctccta ttgctgagct gcctggccaa aacaggagtc
ctgggtgata 180 tcatcatgag acccagctgt gctcctggat ggttttacca
caagtccaat tgctatggtt 240 acttcaggaa gctgaggaac tggtctgatg
ccgagctcga gtgtcagtct tacggaaacg 300 gagcccacct ggcatctatc
ctgagtttaa aggaagccag caccatagca gagtacataa 360 gtggctatca
gagaagccag ccgatatgga ttggcctgca cgacccacag aagaggcagc 420
agtggcagtg gattgatggg gccatgtatc tgtacagatc ctggtctggc aagtccatgg
480 gtgggaacaa gcactgtgct gagatgagct ccaataacaa ctttttaact
tggagcagca 540 acgaatgcaa caagcgccaa cacttcctgt gcaagtaccg
accatagagc aagaatcaag 600 attctgctaa ctcctgcaca gccccgtcct
cttcctttct gctagcctgg ctaaatctgc 660 tcattatttc agaggggaaa
cctagcaaac taagagtgat aagggcccta ctacactggc 720 ttttttaggc
ttagagacag aaactttagc attggcccag tagtggcttc tagctctaaa 780
tgtttgcccc gccatccctt tccacagtat ccttcttccc tcctcccctg tctctggctg
840 tctcgagcag tctagaagag tgcatctcca gcctatgaaa cagctgggtc
tttggccata 900 agaagtaaag atttgaagac agaaggaaga aactcaggag
taagcttcta gaccccttca 960 gcttctacac ccttctgccc tctctccatt
gcctgcaccc caccccagcc actcaactcc 1020 tgcttgtttt tcctttggcc
ataggaaggt ttaccagtag aatccttgct aggttgatgt 1080 gggccataca
ttcctttaat aaaccattgt gtac 1114 <210> SEQ ID NO 172
<211> LENGTH: 158 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 172 Met Ala Ser Arg Ser Met Arg
Leu Leu Leu Leu Leu Ser Cys Leu Ala 1 5 10 15 Lys Thr Gly Val Leu
Gly Asp Ile Ile Met Arg Pro Ser Cys Ala Pro 20 25 30 Gly Trp Phe
Tyr His Lys Ser Asn Cys Tyr Gly Tyr Phe Arg Lys Leu 35 40 45 Arg
Asn Trp Ser Asp Ala Glu Leu Glu Cys Gln Ser Tyr Gly Asn Gly 50 55
60 Ala His Leu Ala Ser Ile Leu Ser Leu Lys Glu Ala Ser Thr Ile Ala
65 70 75 80 Glu Tyr Ile Ser Gly Tyr Gln Arg Ser Gln Pro Ile Trp Ile
Gly Leu 85 90 95 His Asp Pro Gln Lys Arg Gln Gln Trp Gln Trp Ile
Asp Gly Ala Met 100 105 110 Tyr Leu Tyr Arg Ser Trp Ser Gly Lys Ser
Met Gly Gly Asn Lys His 115 120 125 Cys Ala Glu Met Ser Ser Asn Asn
Asn Phe Leu Thr Trp Ser Ser Asn 130 135 140 Glu Cys Asn Lys Arg Gln
His Phe Leu Cys Lys Tyr Arg Pro 145 150 155 <210> SEQ ID NO
173 <211> LENGTH: 137 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <220> FEATURE: <223> OTHER
INFORMATION: human mature J chain <400> SEQUENCE: 173 Gln Glu
Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 1 5 10 15
Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 20
25 30 Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg
Glu 35 40 45 Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe
Val Tyr His 50 55 60 Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr
Glu Val Glu Leu Asp 65 70 75 80 Asn Gln Ile Val Thr Ala Thr Gln Ser
Asn Ile Cys Asp Glu Asp Ser 85 90 95 Ala Thr Glu Thr Cys Tyr Thr
Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 100 105 110 Val Val Pro Leu Val
Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 115 120 125 Leu Thr Pro
Asp Ala Cys Tyr Pro Asp 130 135 <210> SEQ ID NO 174
<211> LENGTH: 137 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Mutant form of human mature J chain with C134S
mutation compared to wild type Mature form of human J chain (SEQ ID
NO:173) <400> SEQUENCE: 174 Gln Glu Asp Glu Arg Ile Val Leu
Val Asp Asn Lys Cys Lys Cys Ala 1 5 10 15 Arg Ile Thr Ser Arg Ile
Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 20 25 30 Ile Val Glu Arg
Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu 35 40 45 Asn Ile
Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His 50 55 60
Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 65
70 75 80 Asn Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu
Asp Ser 85 90 95 Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg Asn Lys
Cys Tyr Thr Ala 100 105 110 Val Val Pro Leu Val Tyr Gly Gly Glu Thr
Lys Met Val Glu Thr Ala 115 120 125 Leu Thr Pro Asp Ala Ser Tyr Pro
Asp 130 135 <210> SEQ ID NO 175 <211> LENGTH: 112
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Mutant form of
human mature J chain with amino acids 113-137 deleted compared to
wild type Mature form of human J chain (SEQ ID NO:173) <400>
SEQUENCE: 175 Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys
Lys Cys Ala 1 5 10 15 Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu
Asp Pro Asn Glu Asp 20 25 30 Ile Val Glu Arg Asn Ile Arg Ile Ile
Val Pro Leu Asn Asn Arg Glu 35 40 45 Asn Ile Ser Asp Pro Thr Ser
Pro Leu Arg Thr Arg Phe Val Tyr His 50 55 60 Leu Ser Asp Leu Cys
Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 65 70 75 80 Asn Gln Ile
Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser 85 90 95 Ala
Thr Glu Thr Cys Tyr Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 100 105
110 <210> SEQ ID NO 176 <211> LENGTH: 137 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Mutant form of human mature
J chain with C109S and C134S mutation compared to wild type mature
form of human J chain (SEQ ID NO:173) <400> SEQUENCE: 176 Gln
Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 1 5 10
15 Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp
20 25 30 Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn
Arg Glu 35 40 45 Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg
Phe Val Tyr His 50 55 60 Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro
Thr Glu Val Glu Leu Asp 65 70 75 80 Asn Gln Ile Val Thr Ala Thr Gln
Ser Asn Ile Cys Asp Glu Asp Ser 85 90 95 Ala Thr Glu Thr Cys Tyr
Thr Tyr Asp Arg Asn Lys Ser Tyr Thr Ala 100 105 110 Val Val Pro Leu
Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 115 120 125 Leu Thr
Pro Asp Ala Ser Tyr Pro Asp 130 135
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 176
<210> SEQ ID NO 1 <211> LENGTH: 254 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGB0101 <400>
SEQUENCE: 1 Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro
Gly Arg 1 5 10 15 Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr
Phe Ser Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly
Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys
Gly Ile Arg Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Asp Gly 100 105 110
Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115
120 125 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly 130 135 140 Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val
Ala Leu Gly 145 150 155 160 Gln Thr Val Arg Ile Thr Cys Gln Gly Asp
Ser Leu Arg Ser Tyr Tyr 165 170 175 Thr Asn Trp Phe Gln Gln Arg Pro
Gly Gln Ala Pro Leu Leu Val Val 180 185 190 Tyr Ala Lys Asn Lys Arg
Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 195 200 205 Ser Ser Ser Gly
Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 210 215 220 Glu Asp
Glu Ala Asp Tyr Tyr Cys His Ser Arg Asp Ser Ser Gly Asn 225 230 235
240 His Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250
<210> SEQ ID NO 2 <211> LENGTH: 251 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGB0102 <400>
SEQUENCE: 2 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro
Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
Phe Thr Asp Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly
Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Lys Ser Gly
Asp Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met
Ala Arg Asp Thr Ser Met Ser Thr Ala Ser 65 70 75 80 Val Glu Leu Arg
Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg
Asn Ser Phe Asp Phe Gly Ser Gly Tyr Gly Leu Phe Tyr Gln 100 105 110
Tyr Ile Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115
120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Asp 130 135 140 Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser
Val Gly Asp 145 150 155 160 Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
Gly Ile Asn Asn Tyr Leu 165 170 175 Ala Trp Tyr Gln Gln Lys Pro Gly
Arg Ala Pro Lys Leu Leu Ile Tyr 180 185 190 Ala Ala Ser Ser Leu Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 195 200 205 Gly Ser Gly Thr
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 210 215 220 Asp Phe
Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Asp Tyr Pro Leu Thr 225 230 235
240 Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 245 250 <210>
SEQ ID NO 3 <211> LENGTH: 255 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGB0103 <400>
SEQUENCE: 3 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr
Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly
Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg
His Tyr Gln Ser Gly Gly Tyr Val Tyr Ile Thr Phe Tyr Tyr 100 105 110
Pro Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 115
120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
Leu 130 135 140 Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser
Pro Gly Lys 145 150 155 160 Thr Val Thr Leu Ser Cys Thr Arg Ser Ser
Gly Ser Ile Ser Phe Asp 165 170 175 Tyr Val Gln Trp Tyr Gln Gln Arg
Pro Gly Ser Ser Pro Ile Leu Val 180 185 190 Ile Phe Glu Asp Asp Gln
Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 195 200 205 Gly Ser Ile Asp
Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 210 215 220 Leu Gln
Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp Asp 225 230 235
240 Asn Arg Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245
250 255 <210> SEQ ID NO 4 <211> LENGTH: 248 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGB0104
<400> SEQUENCE: 4 Glu Val Gln Leu Leu Glu Ser Gly Gly Asp Leu
Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly
Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Glu Asp Arg Met Arg Thr Gln Leu Asp Ser Trp Gly Arg Gly
100 105 110 Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr
Gln Pro Pro Ser 130 135 140 Val Ser Gly Ala Pro Gly Gln Arg Val Thr
Ile Ser Cys Thr Gly Ser 145 150 155 160 Ser Ser Asn Ile Gly Ala Asp
Tyr Asp Val His Trp Tyr Gln His His 165 170 175 Pro Gly Thr Ala Pro
Arg Leu Leu Ile Tyr Asp Asn Thr Asn Arg Pro 180 185 190 Ser Gly Val
Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala 195 200 205 Ser
Leu Thr Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 210 215
220 Cys Gln Ser Tyr Asp Ala Ser Leu Ser Gly Tyr Val Val Phe Gly Gly
225 230 235 240 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ
ID NO 5 <211> LENGTH: 248 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGB0106 <400> SEQUENCE: 5 Lys
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10
15
Ser Val Arg Val Ser Cys Lys Val Ser Gly Asp Thr Ser Thr Ser Tyr 20
25 30 Ile Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45 Gly Val Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala
Gln Lys Phe 50 55 60 Glu Asp Arg Val Thr Ile Ser Ala Asp Gly Ser
Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Gly Leu Lys Ser Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gly Ser Asp Phe Trp Ser
Gly Tyr Asp Gly Glu Pro Asp Val Phe 100 105 110 Asp Leu Trp Gly Gln
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 115 120 125 Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr 130 135 140 Gln
Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr 145 150
155 160 Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gln
Gln 165 170 175 Lys Pro Gly Gln Ala Pro Leu Leu Val Val Tyr Ala Lys
Asn Lys Arg 180 185 190 Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
Ser Ser Gly Asn Thr 195 200 205 Ala Ser Leu Thr Ile Thr Gly Ala Gln
Ala Glu Asp Glu Ala Asp Tyr 210 215 220 Tyr Cys His Ser Arg Asp Ser
Ser Gly Asn His Val Leu Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu
Thr Val Leu Gly 245 <210> SEQ ID NO 6 <211> LENGTH: 243
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGB0110 <400> SEQUENCE: 6 Glu Val Gln Leu Val Gln Ser Gly Gly
Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile
Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70
75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Lys Ala Ser Thr Tyr Tyr Asp Phe Trp Phe Asp Ile
Trp Gly Gln 100 105 110 Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Asp Ile
Gln Met Thr Gln Ser Pro Ser 130 135 140 Phe Leu Ser Ala Ser Val Gly
Asp Arg Val Thr Ile Thr Cys Arg Ala 145 150 155 160 Ser Gln Gly Ile
Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 165 170 175 Arg Ala
Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 180 185 190
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 195
200 205 Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
Leu 210 215 220 Gln Asp Ser Asp Tyr Pro Leu Thr Phe Gly Gly Gly Thr
Lys Leu Glu 225 230 235 240 Ile Lys Arg <210> SEQ ID NO 7
<211> LENGTH: 248 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGB0113 <400> SEQUENCE: 7 Gly Val
Gln Leu Val Gln Ser Gly Ala Glu Gly Lys Lys Pro Gly Ala 1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Asn Ile Ser Arg Phe 20
25 30 Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45 Gly Val Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala
Gln Lys Phe 50 55 60 Glu Asp Arg Val Thr Ile Ser Ala Asp Gly Ser
Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Gly Leu Lys Ser Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gly Ser Asp Phe Trp Ser
Gly Tyr Asp Gly Glu Pro Asp Val Phe 100 105 110 Asp Leu Trp Gly Arg
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 115 120 125 Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr 130 135 140 Gln
Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr 145 150
155 160 Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gln
Gln 165 170 175 Lys Pro Gly Gln Ala Pro Leu Leu Val Val Tyr Ala Lys
Asn Lys Arg 180 185 190 Pro Ser Glu Ile Pro Asp Arg Phe Ser Gly Ser
Ser Ser Gly Asn Thr 195 200 205 Ala Ser Leu Thr Ile Thr Gly Ala Gln
Ala Glu Asp Glu Ala Asp Tyr 210 215 220 Tyr Cys His Ser Arg Asp Ser
Ser Gly Asn His Val Leu Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu
Thr Val Leu Gly 245 <210> SEQ ID NO 8 <400> SEQUENCE: 8
000 <210> SEQ ID NO 9 <211> LENGTH: 249 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGB0115
<400> SEQUENCE: 9 Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu
Val Lys Pro Ser Gly 1 5 10 15 Thr Leu Ser Leu Asn Cys Ala Val Ser
Gly Asp Ser Ile Ser Ser Gly 20 25 30 Asn Trp Trp Ser Trp Val Arg
Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Thr Gly Glu Ile Tyr
His Ser Gly Thr Ala Asn Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg
Val Thr Val Ser Val Asp Lys Ser Thr Asn Gln Phe Ser 65 70 75 80 Leu
Arg Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Ala Gly Tyr Tyr Asp Val Gly Leu Pro Phe Asp Tyr Trp Gly
100 105 110 Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ala Val
Leu Thr Gln Pro 130 135 140 Ser Ser Val Ser Gly Ala Pro Gly Gln Arg
Val Thr Leu Ser Cys Thr 145 150 155 160 Gly Ser Ser Ser Asn Ile Gly
Ala Gly Ser Glu Phe His Trp Tyr Gln 165 170 175 Gln Val Pro Gly Thr
Ala Pro Lys Leu Leu Ile Phe Gly Asn Thr Asn 180 185 190 Arg Pro Trp
Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 195 200 205 Ser
Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp 210 215
220 Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Ala Tyr Val Phe Gly
225 230 235 240 Thr Gly Thr Lys Val Thr Val Leu Gly 245 <210>
SEQ ID NO 10 <211> LENGTH: 247 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGB0118 <400>
SEQUENCE: 10 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
Thr Phe Thr Asp Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Asn Ser
Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr
Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu
Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 85 90 95
Ala Arg Asp Leu Leu Ser Tyr Phe Tyr Asp Ser Ser Gly Tyr Leu Asp 100
105 110 Asn Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly
Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu
Leu Thr Gln 130 135 140 Asp Thr Ala Val Ser Val Ala Leu Gly Gln Thr
Val Arg Ile Thr Cys 145 150 155 160 Gln Gly Asp Ser Leu Arg Ser Tyr
Tyr Thr Asn Trp Phe Gln Gln Lys 165 170 175 Pro Gly Gln Ala Pro Leu
Leu Val Val Tyr Ala Lys Asn Lys Arg Pro 180 185 190 Ser Gly Ile Pro
Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala 195 200 205 Ser Leu
Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 210 215 220
Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly Gly 225
230 235 240 Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
11 <211> LENGTH: 248 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGB0128 <400> SEQUENCE: 11
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asp Pro
Trp Ser Asp Ala Phe Asp Leu Trp Gly Arg Gly 100 105 110 Thr Leu Val
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser
Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 130 135
140 Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly
145 150 155 160 Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr
Gln Gln Arg 165 170 175 Pro Gly Ser Ala Pro Ala Thr Val Ile Tyr Glu
Asp Asn Gln Arg Pro 180 185 190 Ser Gly Val Pro Asp Arg Phe Ser Gly
Ser Ile Asp Ser Ser Ser Asn 195 200 205 Ser Ala Ser Leu Thr Ile Ser
Asp Leu Lys Thr Glu Asp Glu Ala Asp 210 215 220 Tyr Tyr Cys Gln Ser
Phe Asp Asn Ser Lys Tyr Val Val Phe Gly Gly 225 230 235 240 Gly Thr
Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 12 <211>
LENGTH: 252 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGB0129 <400> SEQUENCE: 12 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Asp Cys Thr Asn Gly Val Cys
Tyr Leu Pro Phe Asp 100 105 110 Tyr Trp Gly Arg Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ala Leu Asn Phe Met 130 135 140 Leu Thr Gln Pro His
Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr 145 150 155 160 Leu Ser
Cys Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp Tyr Val Gln 165 170 175
Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu Val Ile Phe Glu 180
185 190 Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser
Ile 195 200 205 Asp Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
Leu Gln Ser 210 215 220 Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr
Asp Asp Asn Arg Gln 225 230 235 240 Val Phe Gly Gly Gly Thr Lys Leu
Thr Val Leu Gly 245 250 <210> SEQ ID NO 13 <211>
LENGTH: 246 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGB0137 <400> SEQUENCE: 13 Glu Val Gln Leu Val Gln
Ser Gly Ala Glu Val Glu Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val
Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Gly Asp 20 25 30 Tyr Met
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45
Gly Arg Ile Asp Pro Lys Tyr Gly Asp Thr Asn Tyr Ala Gln Lys Phe 50
55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val
Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Leu
Tyr Phe Cys 85 90 95 Ala Thr Asp Asn Ser Gly Leu Tyr Asp Ala Phe
Asp Lys Trp Gly Lys 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser
Gln Ser Val Leu Thr Gln Pro Ala Ser 130 135 140 Val Ser Gly Ser Pro
Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr 145 150 155 160 Ser Ser
Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His 165 170 175
Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Gly Ser Lys Arg Pro 180
185 190 Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr
Ala 195 200 205 Ser Leu Thr Ile Ser Arg Leu Gln Ala Glu Asp Glu Ala
Asp Tyr Tyr 210 215 220 Cys Ser Ser Tyr Thr Thr Arg Ser Thr Arg Val
Phe Gly Gly Gly Thr 225 230 235 240 Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 14 <211> LENGTH: 249 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGB0146 <400>
SEQUENCE: 14 Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Lys
Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly
Ser Ile Ser Arg Gly 20 25 30 Gly Tyr Tyr Trp Ser Trp Ile Arg Gln
Leu Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr His
Ser Gly Ser Thr Tyr Tyr Asn Pro Pro 50 55 60 Leu Lys Ser Arg Val
Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys
Ala Arg Glu Lys Gly Gly Asp Trp Glu Gln Leu Val Phe Asp His 100 105
110 Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu
Thr Gln 130 135 140 Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val
Thr Ile Ser Cys 145 150 155 160 Ser Gly Ser Thr Ser Asn Ile Gly Asn
Asn Tyr Val Ser Trp Tyr Gln 165 170 175 Gln His Pro Gly Lys Ala Pro
Lys Leu Met Ile Tyr Asp Val Ser Lys 180 185 190
Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn 195
200 205 Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala
Asp 210 215 220 Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe
Leu Phe Gly 225 230 235 240 Thr Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 15 <211> LENGTH: 249 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGB0153 <400>
SEQUENCE: 15 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Gly Ala Gly Ala Thr Pro Phe Asn Ala Phe Asp Ile Trp Gly 100 105
110 Arg Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu
Thr Gln 130 135 140 Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val
Thr Leu Ser Cys 145 150 155 160 Thr Arg Ser Ser Gly Ser Ile Ser Phe
Asp Tyr Val Gln Trp Tyr Gln 165 170 175 Gln Arg Pro Gly Ser Ser Pro
Ile Leu Val Ile Phe Glu Asp Asp Gln 180 185 190 Arg Pro Ser Gly Val
Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Thr 195 200 205 Ser Asn Ser
Ala Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu Asp Glu 210 215 220 Gly
Asp Tyr Tyr Cys Gln Thr Tyr Asp Asp Asn Arg Gln Val Phe Gly 225 230
235 240 Gly Gly Thr Lys Val Thr Val Leu Gly 245 <210> SEQ ID
NO 16 <211> LENGTH: 247 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGB0163 <400> SEQUENCE: 16
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Pro Tyr
Tyr Asp Ser Ser Gly Tyr Tyr Pro Phe Ser Tyr 100 105 110 Trp Gly Arg
Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr 130 135
140 Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Thr Ile Thr
145 150 155 160 Cys Gly Gly Asp Phe Ala Thr Lys Asn Val Asn Trp Tyr
Gln Arg Lys 165 170 175 Pro Gly Gln Ala Pro Val Thr Val Ile Tyr Tyr
Asp Thr Glu Arg Pro 180 185 190 Ser Ala Ile Pro Glu Arg Phe Ser Gly
Ser Asn Thr Gly Ser Thr Ala 195 200 205 Thr Leu Thr Ile Ser Arg Val
Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 210 215 220 Cys Gln Val Trp Asp
Ser Phe Thr Asp His Arg Leu Phe Gly Gly Gly 225 230 235 240 Thr Lys
Leu Thr Val Leu Gly 245 <210> SEQ ID NO 17 <211>
LENGTH: 253 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGB0165 <400> SEQUENCE: 17 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Gly Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Thr Gly Gly Ser Gly Ser Pro Val Tyr Tyr
Tyr Tyr His Tyr Leu 100 105 110 Asp Val Trp Gly Arg Gly Thr Leu Val
Thr Val Ser Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Ala Leu Asn Phe 130 135 140 Met Leu Thr Gln Pro
His Ser Val Ser Glu Ser Pro Gly Lys Thr Val 145 150 155 160 Thr Leu
Ser Cys Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp Tyr Val 165 170 175
Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu Val Ile Phe 180
185 190 Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly
Ser 195 200 205 Ile Asp Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser
Gly Leu Gln 210 215 220 Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Thr
Tyr Asp Asp Asn Arg 225 230 235 240 Gln Val Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu Gly 245 250 <210> SEQ ID NO 18 <211>
LENGTH: 248 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGB0174 <400> SEQUENCE: 18 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Ser Asp Ser Asp Ser Ser Asp Tyr Tyr Tyr
Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly
Ser Ala Gln Ser Val Leu Thr Gln Pro 130 135 140 Pro Ser Ala Ser Gly
Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 145 150 155 160 Gly Ser
Ser Ser Asn Ile Gly Phe Asn Asp Val Tyr Trp Tyr Gln Gln 165 170 175
Leu Pro Gly Leu Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg 180
185 190 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Glu Ser Gly Thr
Ser 195 200 205 Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu
Ala Asp Tyr 210 215 220 Tyr Cys Ala Thr Trp Asp Asp Ser Leu Ser Ala
Pro Val Phe Gly Gly 225 230 235 240 Gly Thr Lys Val Thr Val Leu Gly
245 <210> SEQ ID NO 19 <211> LENGTH: 251 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGB0185
<400> SEQUENCE: 19 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn
Pro Lys Ser Gly Asp Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly
Arg Val Thr Met Ala Arg Asp Thr Ser Met Ser Thr Ala Ser 65 70 75 80
Val Glu Leu Arg Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asn Ser Phe Asp Phe Gly Ser Gly Tyr Gly Leu Phe Tyr
Gln 100 105 110 Tyr Ile Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser 115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Asp 130 135 140 Ile Gln Met Thr Gln Ser Pro Ser Phe
Leu Ser Ala Ser Val Gly Asp 145 150 155 160 Arg Val Thr Ile Thr Cys
Arg Ala Ser Gln Gly Ile Asn Asn Tyr Leu 165 170 175 Ala Trp Tyr Gln
Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr 180 185 190 Ala Ala
Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 195 200 205
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 210
215 220 Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Asp Tyr Pro Leu
Thr 225 230 235 240 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245
250 <210> SEQ ID NO 20 <211> LENGTH: 253 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGB0187
<400> SEQUENCE: 20 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asp Ser Cys Pro Tyr Cys Ser Thr Asn Ser Gly Ser Phe
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Leu Asn Phe Met 130 135 140 Leu Thr Gln Pro His Ser Val Ser Glu
Ser Pro Gly Lys Thr Val Thr 145 150 155 160 Ile Ser Cys Thr Arg Thr
Ser Gly Asn Ile Ala Gly Tyr Phe Val Gln 165 170 175 Trp Tyr Gln Gln
Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu 180 185 190 Asp Tyr
Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile 195 200 205
Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Pro 210
215 220 Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asp Thr Ser
Gln 225 230 235 240 Gly Val Phe Gly Ala Gly Thr Lys Leu Thr Val Leu
Gly 245 250 <210> SEQ ID NO 21 <211> LENGTH: 248
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGB0194 <400> SEQUENCE: 21 Glu Val Gln Leu Val Glu Ser Gly
Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Gly Thr Leu Ser Arg Phe 20 25 30 Gly Ile Asn Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Val
Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60
Glu Asp Arg Val Thr Ile Ser Ala Asp Gly Ser Thr Ser Thr Val Tyr 65
70 75 80 Met Glu Leu Ser Gly Leu Lys Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Gly Ser Asp Phe Trp Ser Gly Tyr Asp Gly Glu
Pro Asp Val Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser Glu Leu Thr 130 135 140 Gln Asp Pro Ala Ala Ser
Val Ala Leu Gly Gln Thr Val Arg Ile Thr 145 150 155 160 Cys Gln Gly
Asp Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gln Gln 165 170 175 Lys
Pro Gly Gln Ala Pro Leu Leu Val Val Tyr Ala Lys Asn Lys Arg 180 185
190 Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr
195 200 205 Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala
Asp Tyr 210 215 220 Tyr Cys His Ser Arg Asp Ser Ser Gly Asn His Val
Leu Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 22 <211> LENGTH: 250 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0102 <400>
SEQUENCE: 22 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys
Pro Ser Gly 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly
Ser Ile Ser Ser Ser 20 25 30 Asn Tyr Trp Ser Trp Val Arg Gln Pro
Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Glu Ile Tyr His Asp
Gly Ser Thr Asn Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Val Thr
Met Ser Ala Asp Lys Ser Lys Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu
Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Asp Ser Pro Ser Tyr Ser Ser Gly Trp Tyr Ser Asp Tyr Trp 100 105
110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu
Thr Gln 130 135 140 Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val
Thr Ile Ser Cys 145 150 155 160 Ser Gly Ser Ser Ser Asn Ile Gly Ser
Asn Thr Val Asn Trp Tyr Gln 165 170 175 Gln Leu Pro Gly Thr Ala Pro
Lys Leu Leu Ile Phe Ser Asn Asn Gln 180 185 190 Arg Pro Ser Gly Val
Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 195 200 205 Ser Ala Ser
Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Val 210 215 220 Tyr
Tyr Cys Ala Ala Trp Asp Asp Ser Leu Thr Gly Phe Tyr Val Phe 225 230
235 240 Gly Ala Gly Thr Lys Val Thr Val Leu Gly 245 250 <210>
SEQ ID NO 23 <211> LENGTH: 242 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0104 <400>
SEQUENCE: 23 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys
Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Thr Thr Ser Glu Asn
Thr Phe Arg Arg Ser 20 25 30 Ser Phe Ser Trp Leu Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Ile
His Ser Glu Thr Tyr Ala Gln Asn Phe 50 55 60 Gln Gly Arg Val Thr
Met Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 65 70 75 80 Val Glu Val
Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95 Ala Arg Asp Ser Pro Pro Tyr Asn Ala Asp Phe Asp Phe Trp
Gly Arg 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser
Val Leu Thr Gln Pro Pro 130 135 140 Ser Val Ser Val Ser Pro Gly Gln
Thr Ala Thr Ile Thr Cys Ser Gly 145 150 155 160 Asp Lys Leu Gly Asp
Lys Tyr Ala Ser Trp Tyr Gln Lys Lys Ala Gly 165 170 175 Gln Ser Pro
Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly 180 185 190 Ile
Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu 195 200
205 Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln
210 215 220 Ala Trp Asp Ser Ser Val Val Phe Gly Gly Gly Thr Lys Val
Thr Val 225 230 235 240 Leu Gly <210> SEQ ID NO 24
<211> LENGTH: 246 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGC0107 <400> SEQUENCE: 24 Gln Val
Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Leu Ser Arg Ser 20
25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu
Glu 35 40 45 Trp Ile Gly Ser Val Phe Tyr Ser Gly Ser Ala Asp Tyr
Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Ser Ile Ser Val Asp Thr
Tyr Gln Asn Gln Val 65 70 75 80 Ser Leu Lys Leu Thr Ser Val Thr Ala
Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Asp Asp Gly Ser
Thr Phe Asp Pro Trp Gly Arg Gly Thr 100 105 110 Leu Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly
Gly Ser Ala Leu Ser Tyr Val Leu Thr Gln Pro Pro Ser 130 135 140 Ala
Ser Glu Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 145 150
155 160 Ser Ala Asn Ile Glu Tyr Asn Phe Val Tyr Trp Tyr Gln Gln Leu
Pro 165 170 175 Gly Thr Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln
Arg Pro Ser 180 185 190 Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser
Gly Thr Ser Ala Ser 195 200 205 Leu Ala Ile Ser Gly Leu Arg Ser Glu
Asp Glu Ala Asp Tyr Tyr Cys 210 215 220 Ala Ala Trp Asp Asp Ser Leu
Asn Gly Tyr Val Phe Gly Thr Gly Thr 225 230 235 240 Lys Val Thr Val
Leu Gly 245 <210> SEQ ID NO 25 <211> LENGTH: 246
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0108 <400> SEQUENCE: 25 Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys
Thr Val Ser Gly Asp Ser Ile Asp Lys Ser 20 25 30 Ser Tyr Tyr Trp
Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile
Ala Ser Val Phe Tyr Asp Gly Thr Ala Asp Tyr Ser Pro Ser 50 55 60
Leu Arg Ser Arg Val Ser Met Ser Val Asp Arg Ser Leu Asn His Val 65
70 75 80 Ser Leu Arg Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr
Tyr Tyr 85 90 95 Cys Ala Arg Asp Asp Gly Ser Ser Phe Asp Pro Trp
Gly Arg Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Ala Leu Ser
Tyr Val Leu Thr Gln Pro Pro Ser 130 135 140 Ala Ser Gly Thr Pro Gly
Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 145 150 155 160 Ser Ser Asn
Thr Gly Ser Asn Tyr Val Tyr Trp Tyr Gln Gln Leu Pro 165 170 175 Gly
Thr Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser 180 185
190 Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser
195 200 205 Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr
Tyr Cys 210 215 220 Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val Phe
Gly Thr Gly Thr 225 230 235 240 Lys Val Thr Val Leu Gly 245
<210> SEQ ID NO 26 <211> LENGTH: 246 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0110 <400>
SEQUENCE: 26 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Thr Phe Asn Arg Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Ile Ile Asn Pro Arg Gly
Asp Ser Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr
Leu Thr Arg Asp Thr Ser Ala Arg Thr Val Tyr 65 70 75 80 Met Glu Met
Asn Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Glu Gly Val Gly Ala Thr Trp Val His Trp Gly Lys Gly Thr 100 105
110 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125 Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro
His Ser 130 135 140 Val Ser Gly Ser Pro Gly Lys Thr Val Thr Ile Ser
Cys Thr Gly Ser 145 150 155 160 Ser Gly Ser Ile Ala Ser Asn Tyr Val
Gln Trp Tyr Gln Gln Arg Pro 165 170 175 Gly Ser Ala Pro Thr Thr Val
Ile Tyr Glu Asp Asn Gln Arg Pro Ser 180 185 190 Gly Val Pro Asp Arg
Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser 195 200 205 Ala Ser Leu
Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr 210 215 220 Tyr
Cys Gln Ser Ser Asp Thr Met Phe Gln Val Phe Gly Gly Gly Thr 225 230
235 240 Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 27
<211> LENGTH: 246 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGC0114 <400> SEQUENCE: 27 Gln Met
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 20
25 30 Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45 Gly Val Ile Ile Ser Asn Leu Gly Thr Pro Tyr Tyr Ala
Gln Ser Phe 50 55 60 Gln Gly Arg Val Thr Ile Ser Ala Asp Lys Ser
Thr Gly Thr Val Tyr 65 70 75 80 Leu Asp Val Ser Ser Leu Arg Ser Asp
Asp Ser Ala Thr Tyr Tyr Cys 85 90 95 Ala Arg Ala Arg Arg Leu Trp
Gln Thr Phe Asp Ile Trp Gly Lys Gly 100 105 110 Thr Leu Val Thr Val
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly
Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser 130 135 140 Ala
Ser Gly Ala Pro Gly Gln Arg Val Val Ile Ser Cys Ser Gly Ser 145 150
155 160 Thr Ser Ser Ile Gly Ser Asn Thr Val Asn Trp Tyr Lys His Val
Pro 165 170 175 Gly Glu Ala Pro Lys Leu Leu Ile Tyr Ser Ser Thr Gln
Arg Pro Ser 180 185 190 Gly Val Pro Gly Arg Phe Ser Gly Ser Thr Ser
Gly Thr Ser Gly Ser
195 200 205 Leu Thr Ile Ser Gly Leu Gln Ser Gly Asp Glu Ala Asp Tyr
Tyr Cys 210 215 220 Ala Ala Phe Asp Asp Ser Leu Asn Gly Phe Val Phe
Gly Thr Gly Thr 225 230 235 240 Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 28 <211> LENGTH: 242 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0115 <400>
SEQUENCE: 28 Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Val Val Arg
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Asp Asp Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Gly
Gly Ser Thr Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Arg Arg Tyr Ala Leu Asp Tyr Trp Gly Lys Gly Thr Leu Val 100 105
110 Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125 Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Ala
Val Ser 130 135 140 Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln
Gly Asp Ser Leu 145 150 155 160 Arg Asn Tyr Tyr Ala Ser Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro 165 170 175 Val Leu Val Ile Tyr Gly Lys
Asn Asn Arg Pro Ser Gly Ile Pro Val 180 185 190 Arg Phe Ser Gly Ser
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr 195 200 205 Gly Thr Gln
Ala Glu Asp Gly Ala Asp Tyr Tyr Cys Asn Ser Arg Asp 210 215 220 Ser
Ser Gly Lys His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val 225 230
235 240 Leu Gly <210> SEQ ID NO 29 <211> LENGTH: 252
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0128 <400> SEQUENCE: 29 Glu Val Gln Leu Val Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Glu Ala Ser Gly Phe Ser Phe Ser Ser Tyr 20 25 30 Gly Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser
Ile Thr Ser Arg Gly Arg Gly Gly Ser Thr Tyr His Ala Asp 50 55 60
Tyr Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 65
70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr 85 90 95 Tyr Cys Ala Lys Asp Trp Ser Ala Tyr Asp Ser Val
His Leu Phe Asp 100 105 110 Tyr Trp Gly Arg Gly Thr Leu Val Thr Val
Ser Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Leu Asn Phe Met 130 135 140 Leu Thr Gln Pro His Ser
Val Ser Glu Ser Pro Gly Lys Thr Val Thr 145 150 155 160 Ile Ser Cys
Thr Arg Asn Thr Asp Asn Ile Ala Phe Asn Tyr Val Gln 165 170 175 Trp
Phe Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu 180 185
190 Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile
195 200 205 Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu
Lys Thr 210 215 220 Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp
Gly Asn Asn Leu 225 230 235 240 Val Phe Gly Gly Gly Thr Lys Leu Thr
Val Leu Gly 245 250 <210> SEQ ID NO 30 <211> LENGTH:
249 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0130 <400> SEQUENCE: 30 Glu Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Gly Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp
Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65
70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Asp Ala Arg Pro Arg Gly Ile Ala Ala Arg
Pro Leu Leu Ser 100 105 110 Tyr Trp Gly Arg Gly Thr Thr Val Thr Val
Ser Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gln Ser Val Leu Thr 130 135 140 Gln Pro Pro Ser Val Ser
Ala Ala Pro Gly Glu Lys Val Thr Ile Ser 145 150 155 160 Cys Ser Gly
Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp Tyr 165 170 175 Gln
Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser 180 185
190 Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly
195 200 205 Asn Thr Ala Ser Leu Thr Ile Ser Gly Val Gln Ala Glu Asp
Glu Ala 210 215 220 Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ala Ser Thr
Val Ile Phe Gly 225 230 235 240 Gly Gly Thr Lys Leu Thr Val Leu Gly
245 <210> SEQ ID NO 31 <211> LENGTH: 257 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGC0131
<400> SEQUENCE: 31 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Arg Lys Pro Gly Ala 1 5 10 15 Ser Val Arg Val Ser Cys Arg Ala
Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 Asp Ile Asn Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Met Asn
Pro Asn Gly Gly His Thr Gly Ser Ala Gln Lys Phe 50 55 60 Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Gly Ser Gln Trp Cys Thr Gly Gly Asn Cys Tyr Gly Thr
His 100 105 110 Tyr Tyr Tyr Met Glu Asp Trp Gly Arg Gly Thr Leu Val
Thr Val Ser 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 130 135 140 Ala Leu Asn Phe Met Leu Thr Gln Pro
His Ser Val Ser Glu Ser Pro 145 150 155 160 Gly Lys Thr Val Thr Ile
Ser Cys Thr Arg Asn Thr Asp Asn Ile Ala 165 170 175 Phe Asn Tyr Val
Gln Trp Phe Gln Gln Arg Pro Gly Ser Ser Pro Thr 180 185 190 Thr Val
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 195 200 205
Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile 210
215 220 Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser
Tyr 225 230 235 240 Asp Gly Asn Asn Leu Val Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu 245 250 255 Gly <210> SEQ ID NO 32
<211> LENGTH: 244 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGC0137
<400> SEQUENCE: 32 Glu Val Gln Leu Val Gln Ser Gly Ser Glu
Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Arg Val Ser Cys Lys Thr
Ser Gly Asp Thr Phe Arg Arg Phe 20 25 30 Thr Val Ser Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Val Ile
Pro Leu Tyr Asn Ser Pro Thr Tyr Ala Gln Lys Phe 50 55 60 Gln Asp
Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Val Tyr 65 70 75 80
Met Glu Val Thr Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asp Ser Pro Pro Tyr Asn Ala Asp Phe Asp Ser Trp Gly
Gln 100 105 110 Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Gln Ala Val
Leu Thr Gln Pro Ser 130 135 140 Ser Met Ser Val Ser Pro Gly Gln Thr
Ala Ile Ile Thr Cys Ser Gly 145 150 155 160 Asn Arg Leu Gly Asp Lys
Tyr Val Ser Trp Tyr Gln Gln Arg Pro Gly 165 170 175 Gln Ser Pro Val
Leu Val Ile Phe Gln Asp Asn Lys Arg Pro Ser Gly 180 185 190 Ile Ser
Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu 195 200 205
Thr Ile Ser Asp Val Glu Ala Met Asp Glu Ala Glu Tyr Phe Cys Gln 210
215 220 Ala Trp His Ser Ser Phe Tyr Tyr Ala Phe Gly Thr Gly Thr Lys
Leu 225 230 235 240 Thr Val Leu Gly <210> SEQ ID NO 33
<211> LENGTH: 248 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGC0139 <400> SEQUENCE: 33 Glu Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala 1 5 10 15
Ser Met Lys Val Tyr Cys Lys Ala Ser Gly Tyr Arg Phe Thr Arg Tyr 20
25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45 Gly Thr Ile Asn Pro Ser Asp Gly Ser Thr Ser Tyr Ala
Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Met Thr Arg Asp Thr Ser
Thr Arg Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu
Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Gly Arg Val Glu Asp Tyr Tyr
Ser Glu Ser Asn Gly Pro Ala Asp Asn 100 105 110 Trp Gly Arg Gly Thr
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr 130 135 140 Gln
Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Ser Ile Thr 145 150
155 160 Cys Gly Gly Asn Lys Ile Gly Thr Lys Gly Val His Trp Tyr Gln
Gln 165 170 175 Lys Pro Gly Arg Ala Pro Val Leu Val Val Tyr Asp Asp
Gly Asp Arg 180 185 190 Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
Asn Ser Asp Asn Thr 195 200 205 Ala Thr Leu Thr Ile Ser Arg Val Glu
Ala Gly Asp Glu Ala Asp Tyr 210 215 220 Tyr Cys Gln Val Trp Asp Ser
Asp Ser Asp Leu Gly Val Phe Gly Gly 225 230 235 240 Gly Thr Lys Val
Thr Val Leu Gly 245 <210> SEQ ID NO 34 <211> LENGTH:
243 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0142 <400> SEQUENCE: 34 Glu Val Gln Leu Val Gln Ser Gly
Ala Ala Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys
Glu Val Ser Gly Gly Ile Phe Lys Asn Tyr 20 25 30 Ala Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly
Ser Ile Pro Met Tyr Gly Thr Pro Ser Tyr Ala Pro Lys Phe 50 55 60
Gln Gly Arg Val Thr Ile Ile Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65
70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr
Tyr Cys 85 90 95 Ala Arg Glu Thr Thr Glu Val Asp Asp Ala Phe Asp
Ile Trp Gly Arg 100 105 110 Gly Thr Met Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala
Gln Ser Val Leu Thr Gln Pro Pro 130 135 140 Ser Val Ser Ala Ala Pro
Arg Gln Arg Val Thr Ile Ser Cys Ser Gly 145 150 155 160 Ser Ser Ser
Asn Ile Gly Asn Asn Val Val Asn Trp Tyr Gln His Phe 165 170 175 Pro
Gly Lys Ala Pro Arg Leu Leu Ile Phe Ser Asp Ser Leu Leu Ser 180 185
190 Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile
195 200 205 Ser Gly Leu Gln Ser Asp Asp Glu Ala Glu Tyr Tyr Cys Ala
Ser Trp 210 215 220 Asp Asp Ser Leu Asn Gly Leu Val Phe Gly Gly Gly
Thr Lys Leu Thr 225 230 235 240 Val Leu Gly <210> SEQ ID NO
35 <211> LENGTH: 243 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGC0145 <400> SEQUENCE: 35
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5
10 15 Ser Val Lys Ile Ser Cys Glu Val Ser Gly Gly Ile Phe Lys Asn
Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Trp Met 35 40 45 Gly Gly Ser Ile Pro Met Tyr Gly Thr Pro Ser
Tyr Ala Pro Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Ile Ala Asp
Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg
Ser Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Glu Thr Thr
Glu Val Asp Asp Ala Phe Asn Ile Trp Gly Arg 100 105 110 Gly Thr Leu
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly
Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro 130 135
140 Ser Val Ser Ala Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly
145 150 155 160 Ser Ser Ser Asn Ile Gly Asn Asn Val Val Asn Trp Tyr
Gln His Phe 165 170 175 Pro Gly Lys Ala Pro Arg Leu Leu Ile Phe Pro
Asp Ser Leu Leu Ser 180 185 190 Asp Arg Phe Ser Gly Ser Lys Ser Gly
Thr Ser Ala Ser Leu Ala Ile 195 200 205 Ser Gly Leu Gln Ser Asp Asp
Glu Ala Glu Tyr Tyr Cys Ala Ser Trp 210 215 220 Asp Asp Ser Leu Asn
Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr 225 230 235 240 Val Leu
Gly <210> SEQ ID NO 36 <211> LENGTH: 249 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGC0150
<400> SEQUENCE: 36 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
Leu Val Lys Pro Ser Gly 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val
Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 Asn Tyr Trp Ser Trp Val
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Glu Ile
Tyr His Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu 50 55 60 Lys Ser
Arg Val Thr Met Ser Ala Asp Lys Ser Lys Asn Gln Phe Ser 65 70 75 80
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asp Ser Pro Ser Tyr Ser Ser Gly Trp Tyr Ser Asp Tyr
Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln 130
135 140 Pro Pro Ser Ala Ser Gly Thr Pro Gly Arg Arg Val Thr Ile Ser
Cys 145 150 155 160 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val
Asn Trp Tyr Gln 165 170 175 Gln Leu Pro Gly Thr Ala Pro Lys Ile Val
Met Tyr Ser Thr Asp Gln 180 185 190 Arg Thr Ser Gly Ala Pro Asp Arg
Phe Ser Gly Ser Lys Ser Gly Thr 195 200 205 Ser Ala Ser Leu Ala Ile
Thr Gly Leu Gln Ser Glu Asp Glu Ala Asp 210 215 220 Tyr Phe Cys Ala
Thr Trp Asp Asp Ser Pro Asn Ala Val Val Phe Gly 225 230 235 240 Gly
Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 37
<211> LENGTH: 251 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGC0153 <400> SEQUENCE: 37 Glu Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Asp 20
25 30 Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45 Gly Trp Ile Asn Pro Asn Thr Gly Gly Thr Asn Tyr Ala
Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser
Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp
Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Ala Arg Tyr Tyr Tyr
Asp Ser Thr Ser Tyr Pro Phe Asp Tyr 100 105 110 Trp Gly Arg Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu 130 135 140 Thr
Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Leu 145 150
155 160 Ser Cys Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp Tyr Val Gln
Trp 165 170 175 Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu Val Ile
Phe Glu Asp 180 185 190 Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe
Ser Gly Ser Ile Asp 195 200 205 Ser Thr Ser Asn Ser Ala Ser Leu Thr
Ile Ser Gly Leu Gln Ser Glu 210 215 220 Asp Glu Gly Asp Tyr Tyr Cys
Gln Thr Tyr Asp Asp Asn Arg Gln Val 225 230 235 240 Phe Gly Gly Gly
Thr Lys Val Thr Val Leu Gly 245 250 <210> SEQ ID NO 38
<211> LENGTH: 245 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGC0154 <400> SEQUENCE: 38 Gln Val
Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 1 5 10 15
Ser Val Lys Val Ser Cys Thr Thr Ser Glu Asn Thr Phe Arg Arg Ser 20
25 30 Ser Phe Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45 Gly Arg Ile Ile Pro Ile Ile His Ser Glu Thr Tyr Ala
Gln Asn Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Ala Asp Glu Ser
Thr Ser Thr Val Tyr 65 70 75 80 Val Glu Val Arg Ser Leu Arg Ser Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Pro Pro Tyr
Asn Ala Asp Phe Asp Phe Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly
Gly Gly Gly Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro 130 135 140 Pro
Ser Val Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser 145 150
155 160 Gly Asp Asn Leu Gly Asp Lys Tyr Val Ser Trp Tyr Gln Gln Arg
Pro 165 170 175 Gly Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Val Lys
Arg Pro Ser 180 185 190 Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser
Gly Asn Thr Ala Thr 195 200 205 Leu Thr Ile Ser Gly Thr Gln Ala Met
Asp Glu Ala Asp Tyr Tyr Cys 210 215 220 Gln Ala Trp Asp Ser Asn Thr
Ser Tyr Val Phe Gly Thr Gly Thr Gln 225 230 235 240 Leu Thr Val Leu
Ser 245 <210> SEQ ID NO 39 <211> LENGTH: 253
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0157 <400> SEQUENCE: 39 Gln Val Gln Leu Gln Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Gly Thr Phe Asn Ser Ser 20 25 30 Ala Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg
Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Asn Phe 50 55 60
Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65
70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Thr Arg Asp Tyr Val Asp Pro Asp Met Leu Thr Ala
Gly Tyr Tyr Phe 100 105 110 Asp Gln Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ala Leu Asn Phe 130 135 140 Met Leu Thr Gln Pro His
Ser Val Ser Glu Ser Pro Gly Lys Thr Val 145 150 155 160 Thr Ile Ser
Cys Thr Arg Asn Thr Asp Asn Ile Ala Phe Asn Tyr Val 165 170 175 Gln
Trp Phe Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr 180 185
190 Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser
195 200 205 Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
Leu Lys 210 215 220 Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr
Asp Gly Asn Asn 225 230 235 240 Leu Val Phe Gly Gly Gly Thr Lys Leu
Thr Val Leu Gly 245 250 <210> SEQ ID NO 40 <211>
LENGTH: 247 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGC0162 <400> SEQUENCE: 40 Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val
Ser Cys Lys Ala Ala Gly Phe Arg Phe Ser Gly Asp 20 25 30 Tyr Leu
His Trp Leu Arg Gln Val Pro Gly Gln Gly Pro Glu Trp Met 35 40 45
Gly Trp Ile Asn Leu Ser Ser Gly Gly Thr Asn Tyr Gly Glu Lys Phe 50
55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Arg Pro Ser Ser Thr Ala
Tyr 65 70 75 80 Met Glu Ile Lys Ser Leu Arg Val Asp Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Glu Ser Pro Val Val Glu Ala Met Asp
Val Trp Gly Arg Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala
Leu Asn Phe Met Leu Thr Gln Pro His 130 135 140 Ser Val Ser Glu Ser
Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Arg 145 150 155 160 Ser Ser
Asp Asn Ile Ala Phe Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165 170 175
Pro Gly Ser Ala Pro Thr Thr Leu Ile Tyr Glu Asp Asn Gln Arg Pro 180
185 190 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser
Asn 195 200 205 Ser Ala Ser Leu Thr Ile Ser Asn Leu Lys Thr Glu Asp
Glu Ala Asp 210 215 220
Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Asn Tyr Val Phe Gly Thr Gly 225
230 235 240 Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
41 <211> LENGTH: 245 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGC0164 <400> SEQUENCE: 41
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5
10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly
Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Lys Ser Gly Gly Thr Asn
Tyr Pro Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp
Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg
Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Thr
Gly Asp Phe Phe Asp Tyr Trp Gly Arg Gly Thr 100 105 110 Leu Val Thr
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly
Gly Gly Gly Ser Ala Gln Pro Val Leu Thr Gln Pro Pro Ser Ala 130 135
140 Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser
145 150 155 160 Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln
Gln His Pro 165 170 175 Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val
Ser Lys Arg Pro Ser 180 185 190 Gly Val Pro Asp Arg Phe Ser Ala Ser
Lys Ser Gly Asn Thr Ala Ser 195 200 205 Leu Thr Val Ser Gly Leu Gln
Ala Glu Asp Glu Ala Tyr Tyr Tyr Cys 210 215 220 Ser Ser Tyr Ala Gly
Ser Asn Asn Ser Val Phe Gly Gly Gly Thr Lys 225 230 235 240 Leu Thr
Val Leu Gly 245 <210> SEQ ID NO 42 <211> LENGTH: 246
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGC0169 <400> SEQUENCE: 42 Gln Val Gln Leu Gln Glu Ser Gly
Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 20 25 30 Gly Met His Trp
Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 35 40 45 Ala Val
Ile Trp Tyr Asp Gly Ser Arg Gln Tyr Tyr Gly Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr
Tyr Cys 85 90 95 Ala Arg Asp Pro Ser Leu Ala Pro Val Tyr Gln Phe
Asp Tyr Trp Gly 100 105 110 Arg Gly Thr Met Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser
Ala Leu Asp Val Val Met Thr Gln 130 135 140 Ser Pro Ser Ser Leu Ser
Ala Ser Val Gly Glu Arg Val Thr Ile Thr 145 150 155 160 Cys Arg Ala
Ser Gln Asn Ile Phe Asn Asn Leu Asn Trp Tyr Gln Gln 165 170 175 Lys
Pro Gly Asn Ala Pro Ser Leu Leu Ile Ser Asp Ala Ser Ser Leu 180 185
190 Gln Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
195 200 205 Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Leu Gly
Thr Tyr 210 215 220 Tyr Cys Gln Gln Ser Tyr Thr Ile Pro Pro Thr Phe
Gly Gln Gly Thr 225 230 235 240 Arg Leu Glu Ile Lys Arg 245
<210> SEQ ID NO 43 <211> LENGTH: 248 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGC0175 <400>
SEQUENCE: 43 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
Thr Phe Thr Ser Tyr 20 25 30 Gly Ile Asn Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Pro Tyr Asn
Tyr Asn Thr Asn Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr
Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Glu Glu Thr Gly Ser Tyr His Gly Phe Asp Tyr Trp Gly Arg 100 105
110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr
Gln Pro 130 135 140 His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr
Ile Ser Cys Thr 145 150 155 160 Ala Ser Ser Gly Asn Ile Ala Phe Asn
Tyr Val Gln Trp Tyr Gln Gln 165 170 175 Arg Pro Gly Ser Ala Pro Thr
Ile Val Ile Gln Glu Asp Asn Gln Arg 180 185 190 Pro Ser Gly Val Pro
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser 195 200 205 Asn Ser Ala
Ser Leu Thr Ile Ser Gly Leu Lys Ala Glu Asp Glu Gly 210 215 220 Asp
Tyr Tyr Cys Gln Ser Tyr Asp Lys Tyr Tyr Arg Ile Phe Gly Gly 225 230
235 240 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
44 <211> LENGTH: 243 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0102 <400> SEQUENCE: 44
Glu Val Gln Leu Val Gln Ser Gly Gly Glu Val Lys Lys Pro Gly Asp 1 5
10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser His
Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Trp Met 35 40 45 Gly Trp Thr Ser Ala Tyr Ser Gly Ser Thr Asn
Tyr Ala Gln Lys Phe 50 55 60 Arg Gly Arg Val Thr Met Thr Thr Asp
Thr Ser Thr Gly Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg
Pro Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Gly Arg Gly Asp Ser
Tyr Gly Ser Ile Pro Ala Asp Tyr Trp Gly Arg 100 105 110 Gly Thr Leu
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly
Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser 130 135
140 Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
145 150 155 160 Ser Gln Asp Ile Thr Asn Asp Leu Ala Trp Tyr Gln Gln
Lys Pro Gly 165 170 175 Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser
Thr Leu Gln Tyr Gly 180 185 190 Val Pro Thr Arg Phe Ser Gly Ser Gly
Ser Gly Thr Asn Phe Ser Leu 195 200 205 Thr Ile Ser Ser Leu Gln Pro
Glu Asp Phe Ala Thr Tyr Phe Cys Gln 210 215 220 Gln Ser His Ser Phe
Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 225 230 235 240 Ile Lys
Arg <210> SEQ ID NO 45 <211> LENGTH: 254 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGD0108
<400> SEQUENCE: 45 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35
40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asn Tyr Tyr Asp Phe Trp Arg
Gly Tyr Gln Ser Gln Pro Asn 100 105 110 Tyr Met Asp Val Trp Gly Gln
Gly Thr Met Val Thr Val Ser Ser Gly 115 120 125 Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln 130 135 140 Ser Val Leu
Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Glu Gln Arg 145 150 155 160
Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Tyr Asn Tyr 165
170 175 Val Tyr Trp Phe Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu
Ile 180 185 190 Tyr Thr Asn Asn Leu Arg Pro Ser Gly Val Pro Asp Gln
Phe Ser Gly 195 200 205 Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile
Ser Gly Leu Arg Ser 210 215 220 Glu Asp Glu Gly Asp Tyr Tyr Cys Ala
Ala Trp Asp Asp Ser Leu Ser 225 230 235 240 Gly Arg Val Phe Gly Gly
Gly Thr Lys Val Thr Val Leu Gly 245 250 <210> SEQ ID NO 46
<211> LENGTH: 248 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGD0112 <400> SEQUENCE: 46 Glu Val
Gln Leu Leu Glu Ser Gly Gly Ser Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20
25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asp Pro Trp Ser
Asp Ala Phe Asp Leu Trp Gly Arg Gly 100 105 110 Thr Leu Val Thr Val
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly
Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 130 135 140 Ser
Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 145 150
155 160 Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln
Arg 165 170 175 Pro Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn
Gln Arg Pro 180 185 190 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile
Asp Ser Ser Ser Asn 195 200 205 Ser Ala Ser Leu Thr Ile Ser Gly Leu
Lys Thr Glu Asp Glu Ala Asp 210 215 220 Tyr Tyr Cys Gln Ser Tyr Asp
Ser Ser Asn His Trp Val Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu
Thr Val Leu Gly 245 <210> SEQ ID NO 47 <211> LENGTH:
248 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGD0117 <400> SEQUENCE: 47 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Asp Arg Gly Ser Pro Asp Ala Phe Asp Ile
Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala Leu
Asn Phe Met Leu Thr Gln Pro His 130 135 140 Ser Val Ser Glu Ser Pro
Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 145 150 155 160 Ser Ser Gly
Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165 170 175 Pro
Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Tyr Ser Gln Arg Pro 180 185
190 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn
195 200 205 Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu
Ala Asp 210 215 220 Tyr Tyr Cys Gln Ser Phe Asp Thr Asn Asn Gln Gly
Val Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 48 <211> LENGTH: 245 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGD0119 <400>
SEQUENCE: 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Lys Gly Ile Ser Ser Ser Trp Thr Leu Phe Asp Tyr Trp Gly Gln 100 105
110 Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Thr Leu Thr
Gln Ser 130 135 140 Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Ser Ala
Thr Leu Ser Cys 145 150 155 160 Arg Ala Ser Gln Ser Ile Gly Ser Leu
Leu Ala Trp Tyr Gln Gln Arg 165 170 175 Pro Gly Gln Ala Pro Arg Leu
Val Ile Ser Asp Ala Ser Asn Arg Ala 180 185 190 Ser Gly Ile Pro Ala
Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe 195 200 205 Thr Leu Thr
Ile Ser Ser Leu Ala Pro Glu Asp Phe Ala Val Tyr Tyr 210 215 220 Cys
His Gln Arg Ser Met Trp Pro Leu Ser Phe Gly Gly Gly Thr Lys 225 230
235 240 Val Glu Ile Lys Arg 245 <210> SEQ ID NO 49
<211> LENGTH: 244 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGD0121 <400> SEQUENCE: 49 Glu Val
Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20
25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ile His Asn Trp Asn
Asp Met Phe Asp Tyr Trp Gly Arg Gly 100 105 110 Thr Met Val Thr Val
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125
Ser Gly Gly Gly Gly Ser Ala Leu Asp Ile Gln Leu Thr Gln Ser Pro 130
135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Lys Val Thr Ile Ala Cys
Arg 145 150 155 160 Pro Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr
Gln Gln Lys Pro 165 170 175 Gly Lys Pro Pro Arg Leu Leu Ile Tyr Asp
Val Ser Thr Leu Glu Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly
Ser Gly Ser Gly Thr Tyr Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Phe Asp
Asn Tyr Pro Val Thr Phe Gly Gln Gly Thr Arg Leu 225 230 235 240 Glu
Ile Lys Arg <210> SEQ ID NO 50 <211> LENGTH: 247
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGD0122 <400> SEQUENCE: 50 Glu Val Gln Leu Leu Glu Ser Gly
Glu Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Thr Asp Pro Tyr Tyr Asp Ser Ser Gly Tyr Tyr
Pro Phe Ser Tyr 100 105 110 Trp Gly Lys Gly Thr Thr Val Thr Val Ser
Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Ala Gln Ser Val Leu Thr 130 135 140 Gln Pro Pro Ser Val Ser
Val Ala Pro Gly Gln Thr Ala Thr Ile Thr 145 150 155 160 Cys Gly Gly
Asp Phe Ala Thr Lys Ser Val Asn Trp Tyr Gln Arg Lys 165 170 175 Pro
Gly Gln Ala Pro Val Thr Val Ile Tyr Tyr Ser Thr Glu Arg Pro 180 185
190 Pro Ala Ile Pro Glu Arg Phe Ser Gly Ser Asn Thr Gly Ser Thr Ala
195 200 205 Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp
Tyr Tyr 210 215 220 Cys Gln Val Trp Asp Ser Phe Thr Asp His Arg Leu
Phe Gly Gly Gly 225 230 235 240 Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 51 <211> LENGTH: 248 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGD0123 <400>
SEQUENCE: 51 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Tyr Ala Ser Gly Leu Leu Asp Ala Phe Asp Ile Trp Gly Gln 100 105
110 Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln
Pro Pro 130 135 140 Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile
Ser Cys Thr Gly 145 150 155 160 Ser Ser Ser Asn Ile Gly Ala Gly Asn
Asp Val Asn Trp Tyr Gln Gln 165 170 175 Val Pro Gly Arg Ala Pro Lys
Leu Leu Ile Tyr Gly Thr Thr Tyr Arg 180 185 190 Pro Ser Gly Val Pro
Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 195 200 205 Ala Ser Leu
Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr 210 215 220 Phe
Cys Gln Ser Asp Asp Ser Ser Leu Ser Gly Ser Val Phe Gly Gly 225 230
235 240 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
52 <211> LENGTH: 254 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0124 <400> SEQUENCE: 52
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Pro Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Asp Thr Glu
Phe Tyr Tyr Asp Phe Trp Ser Asn Asp Gly Gly 100 105 110 Trp Phe Asp
Thr Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly 115 120 125 Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln 130 135
140 Ala Val Leu Thr Gln Pro Ser Ser Thr Ser Gly Ser Pro Gly Gln Arg
145 150 155 160 Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly
Ser Asn Tyr 165 170 175 Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala
Pro Lys Leu Leu Ile 180 185 190 Tyr Arg Asn Asn Gln Arg Pro Ser Gly
Val Pro Asp Arg Phe Ser Gly 195 200 205 Ser Lys Ser Gly Thr Ser Ala
Ser Leu Ala Ile Ser Gly Leu Arg Ser 210 215 220 Gly Asp Glu Gly Asp
Tyr His Cys Ala Thr Trp Asp Asp Arg Leu Tyr 225 230 235 240 Gly Trp
Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 245 250 <210>
SEQ ID NO 53 <211> LENGTH: 245 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGD0130 <400>
SEQUENCE: 53 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Lys Gly Ile Ser Ser Ser Trp Thr Leu Phe Asp Tyr Trp Gly Gln 100 105
110 Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Thr Leu Thr
Gln Ser 130 135 140 Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Ser Ala
Thr Leu Ser Cys 145 150 155 160 Arg Ala Ser Gln Ser Ile Gly Ser Leu
Leu Ala Trp Tyr Gln Gln Arg 165 170 175 Pro Gly Gln Ala Pro Arg Leu
Val Ile Ser Asp Ala Ser Asn Arg Ala 180 185 190 Ser Gly Ile Pro Ala
Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe 195 200 205 Thr Leu Thr
Ile Ser Ser Leu Ala Pro Glu Asp Phe Ala Val Tyr Tyr 210 215 220 Cys
Gln Gln Arg Ser Met Trp Pro Leu Ser Phe Gly Gly Gly Thr Lys 225 230
235 240
Val Glu Ile Lys Arg 245 <210> SEQ ID NO 54 <211>
LENGTH: 249 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGD0135 <400> SEQUENCE: 54 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Tyr Ala Ser Gly Leu Val Asp Ala Phe
Asp Met Trp Gly Arg 100 105 110 Gly Thr Met Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser
Ala Gln Ala Val Leu Thr Gln Pro Ser 130 135 140 Ser Val Ser Gly Ala
Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly 145 150 155 160 Arg Ser
Ser Asn Ile Gly Ala Gly Tyr Asp Val Asn Trp Tyr Gln Gln 165 170 175
Leu Pro Gly Ala Ala Pro Lys Leu Leu Ile Tyr Asp Asn Asn Tyr Arg 180
185 190 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr
Ser 195 200 205 Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Asp Asp Glu
Ala Val Tyr 210 215 220 Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly
Ser Glu Val Phe Gly 225 230 235 240 Gly Gly Thr Lys Val Thr Val Leu
Gly 245 <210> SEQ ID NO 55 <211> LENGTH: 251
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGD0136 <400> SEQUENCE: 55 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr
Tyr Cys 85 90 95 Ala Lys Asp Ser Leu Gly Leu Trp Phe Gly Leu Gly
His Phe Glu Asn 100 105 110 Trp Gly Arg Gly Thr Leu Val Thr Val Ser
Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Ala Leu Asn Phe Met Leu 130 135 140 Thr Gln Pro His Ser Val
Ser Glu Ser Pro Gly Lys Thr Val Thr Leu 145 150 155 160 Ser Cys Thr
Arg Ser Ser Gly Ser Ile Ser Phe Asp Tyr Val Gln Trp 165 170 175 Tyr
Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu Val Ile Phe Glu Asp 180 185
190 Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp
195 200 205 Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln
Ser Glu 210 215 220 Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp Asp
Asn Arg Gln Val 225 230 235 240 Phe Gly Gly Gly Thr Lys Leu Thr Val
Leu Gly 245 250 <210> SEQ ID NO 56 <211> LENGTH: 248
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGD0141 <400> SEQUENCE: 56 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Asp Ser Leu Tyr Gly Asp Leu Glu Tyr Phe
Gln His Trp Gly 100 105 110 Arg Gly Thr Thr Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser
Ala Gln Ser Val Leu Thr Gln Pro 130 135 140 Ser Ser Ala Ser Gly Asn
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 145 150 155 160 Gly Ser Ser
Ser Asn Ile Gly Asp Asn Pro Val Asp Trp Tyr Gln His 165 170 175 Val
Pro Gly Arg Ala Pro Lys Leu Leu Ile Phe Arg Asp Asn Gln Arg 180 185
190 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Thr Lys Ser Gly Thr Ser
195 200 205 Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala
Asp Tyr 210 215 220 Tyr Cys Glu Ala Trp Asp Asp Ser Leu Asp Ser Pro
Val Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 57 <211> LENGTH: 253 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGD0143 <400>
SEQUENCE: 57 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Ala Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg His Arg Gly Ile Thr Met Tyr Gly Val Leu Arg Pro Gly Asp 100 105
110 Met Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly
115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
Gln Ala 130 135 140 Val Leu Thr Gln Pro Ser Ser Ala Ser Ala Thr Pro
Gly Gln Arg Val 145 150 155 160 Thr Ile Ser Cys Ser Gly Ser Ser Ser
Asn Ile Gly Ser Asn Ser Val 165 170 175 Asn Trp Tyr Gln His Leu Pro
Gly Thr Ala Pro Lys Leu Leu Ile Tyr 180 185 190 Thr Asn Asp Gln Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 195 200 205 Lys Ser Gly
Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu 210 215 220 Asp
Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Thr Leu Thr Gly 225 230
235 240 Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250
<210> SEQ ID NO 58 <211> LENGTH: 242 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGD0145 <400>
SEQUENCE: 58 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Ser Ser Tyr 20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35
40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Arg Tyr Arg Tyr Phe Asp Asn
Trp Gly Gln Gly Thr Met Val 100 105 110 Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Ala Leu
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser 130 135 140 Val Ala Leu
Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 145 150 155 160
Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 165
170 175 Val Leu Val Phe Tyr Gly Lys Lys Asn Arg Pro Ser Gly Ile Pro
Asp 180 185 190 Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ser Ser Leu
Thr Ile Thr 195 200 205 Gly Ala Gln Ala Glu Asp Asp Ala Asp Tyr Tyr
Cys Asn Ser Arg Asp 210 215 220 Ser Ser Gly Asn His Leu Val Phe Gly
Gly Gly Thr Lys Leu Thr Val 225 230 235 240 Leu Gly <210> SEQ
ID NO 59 <211> LENGTH: 251 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0153 <400> SEQUENCE: 59
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Leu Arg Gly
Ser Thr Arg Trp Glu Asp Phe Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly
Lys Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125 Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Thr Val Val 130 135
140 Ile Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly Thr Val Thr Leu
145 150 155 160 Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Thr Tyr
Tyr Pro Ser 165 170 175 Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg
Thr Leu Ile Tyr Asn 180 185 190 Thr Asn Thr Arg Ser Ser Gly Val Pro
Asp Arg Phe Ser Gly Ser Ile 195 200 205 Leu Gly Asn Lys Ala Ala Leu
Thr Ile Thr Gly Ala Gln Ala Asp Asp 210 215 220 Glu Ser Asp Tyr Tyr
Cys Val Leu Tyr Leu Gly Ser Gly Ile Trp Val 225 230 235 240 Phe Gly
Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250 <210> SEQ ID NO
60 <211> LENGTH: 247 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scFv protein RGD0154 <400> SEQUENCE: 60
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Pro Tyr
Tyr Asp Ser Ser Gly Tyr Tyr Pro Phe Ser Tyr 100 105 110 Trp Gly Arg
Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Val Thr 130 135
140 Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Thr Ile Thr
145 150 155 160 Cys Gly Gly Asp Phe Ala Thr Lys Ser Val Asn Trp Tyr
Gln Arg Lys 165 170 175 Pro Gly Gln Ala Pro Val Thr Val Ile Tyr Tyr
Asn Thr Glu Arg Pro 180 185 190 Pro Ala Ile Pro Glu Arg Phe Ser Gly
Ser Asn Thr Gly Ser Thr Ala 195 200 205 Thr Leu Thr Ile Ser Arg Val
Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 210 215 220 Cys Gln Val Trp Asp
Ser Phe Thr Asp His Arg Leu Phe Gly Gly Gly 225 230 235 240 Thr Lys
Val Thr Val Leu Gly 245 <210> SEQ ID NO 61 <211>
LENGTH: 251 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGD0169 <400> SEQUENCE: 61 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Val Arg Arg Val Pro Phe Gly
Ser Gly Ser Tyr Leu 100 105 110 Asn Pro Phe Asp Trp Gly Gln Gly Thr
Met Val Thr Val Ser Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Leu 130 135 140 Ser Tyr Glu Leu Thr
Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 145 150 155 160 Thr Ala
Ser Ile Thr Cys Thr Gly Asp Lys Leu Ala Glu Lys Tyr Val 165 170 175
Ser Trp Tyr Gln Gln Lys Thr Gly Arg Ser Pro Val Leu Val Ile Tyr 180
185 190 Gln Asp Asp Arg Arg Pro Ser Glu Ile Pro Glu Arg Phe Ser Gly
Ser 195 200 205 Asn Ser Gly Asn Thr Ala Thr Leu Thr Val Ser Gly Ala
Gln Ser Met 210 215 220 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp
Ser Asn Thr Val Ile 225 230 235 240 Phe Gly Gly Gly Thr Lys Val Thr
Val Leu Gly 245 250 <210> SEQ ID NO 62 <211> LENGTH:
249 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scFv protein
RGD0170 <400> SEQUENCE: 62 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Gln Gln Pro Phe Thr Asp Ala Phe Asp Ile
Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala Leu
Asn Phe Met Leu Thr Gln Pro His 130 135 140
Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 145
150 155 160 Ser Ser Gly Asn Ile Ala Asn Asn Tyr Val Gln Trp Phe Gln
Gln Arg 165 170 175 Pro Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp
Asn Gln Arg Pro 180 185 190 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser
Ile Asp Ser Ser Ser Asn 195 200 205 Ser Ala Ser Leu Thr Ile Ser Gly
Leu Lys Thr Glu Asp Glu Ala Asp 210 215 220 Tyr Tyr Cys Gln Ser Tyr
Asp Ser Ser Asn Leu Tyr Val Val Phe Gly 225 230 235 240 Gly Gly Thr
Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO 63 <211>
LENGTH: 248 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: scFv
protein RGD0180 <400> SEQUENCE: 63 Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys Asn Thr Leu
Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Leu Gly Asn Trp Asn Asp Val Phe Asp
Tyr Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala
Leu Asn Phe Met Leu Thr Gln Pro His 130 135 140 Ser Val Ser Glu Ser
Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Arg 145 150 155 160 Ser Ser
Gly Ser Ile Ala Asn Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165 170 175
Pro Gly Ser Ala Pro Thr Thr Val Ile Phe Glu Asp Asp Gln Arg Pro 180
185 190 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser
Asn 195 200 205 Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Asp Asp
Glu Ala Asp 210 215 220 Tyr Tyr Cys Gln Ser Asn Asp Gly Thr Asn Pro
Trp Val Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu Thr Val Leu Gly
245 <210> SEQ ID NO 64 <211> LENGTH: 248 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: scFv protein RGD0182
<400> SEQUENCE: 64 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Glu Asp Pro Trp Ser Asp Ala Phe Asp Leu Trp Gly Lys
Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met
Leu Thr Gln Pro His 130 135 140 Ser Val Ser Glu Ser Pro Gly Lys Thr
Val Thr Ile Ser Cys Thr Gly 145 150 155 160 Ser Ser Gly Ser Ile Ala
Asn Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165 170 175 Pro Gly Ser Ala
Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro 180 185 190 Ser Gly
Val Pro Asp Arg Phe Ser Ala Ser Ile Asp Arg Ser Ser Asn 195 200 205
Ser Ala Ser Leu Thr Ile Ser Gly Leu Met Thr Glu Asp Glu Ala Asp 210
215 220 Tyr Tyr Cys Gln Ser Tyr Asp Ser Asn Asn His Trp Val Phe Gly
Gly 225 230 235 240 Gly Thr Lys Leu Thr Val Leu Gly 245 <210>
SEQ ID NO 65 <211> LENGTH: 245 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGD0183 <400>
SEQUENCE: 65 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Gly Ser Asp Ser Ser Asn Trp Phe Phe Asp Tyr Trp Gly Gln 100 105
110 Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Asp Val Val Met Thr
Gln Ser 130 135 140 Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala
Thr Leu Ser Cys 145 150 155 160 Arg Ala Ser Gln Ser Val Ser Ser Phe
Leu Ala Trp Tyr Gln Gln Lys 165 170 175 Pro Gly Gln Ala Pro Arg Leu
Leu Met Tyr Asp Ala Ser Asn Arg Ala 180 185 190 Thr Gly Ile Pro Ala
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 195 200 205 Thr Leu Thr
Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 210 215 220 Cys
Gln Gln Arg Ser Asn Trp Pro Ile Thr Phe Gly Gln Gly Thr Arg 225 230
235 240 Leu Glu Ile Lys Arg 245 <210> SEQ ID NO 66
<211> LENGTH: 242 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scFv protein RGD0193 <400> SEQUENCE: 66 Glu Val
Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20
25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Arg Arg Tyr Ala Leu
Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110 Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser
Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser 130 135 140 Val
Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 145 150
155 160 Arg Asn Tyr Tyr Pro Ser Trp Tyr Gln Gln Ser Pro Gly Gln Ala
Pro 165 170 175 Val Leu Val Ile Tyr Gly Lys Asn Lys Arg Pro Ser Gly
Ile Pro Asp 180 185 190 Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala
Ser Leu Thr Ile Thr 195 200 205 Gly Ala Gln Ala Glu Asp Glu Ala Asp
Tyr Tyr Cys Asn Ser Arg Asp 210 215 220 Ser Ser Gly Asn His Leu Leu
Phe Gly Gly Gly Thr Lys Leu Thr Val 225 230 235 240 Leu Gly
<210> SEQ ID NO 67 <211> LENGTH: 247 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scFv protein RGD0195 <400>
SEQUENCE: 67 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Thr Asp Pro Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro Phe Ser Tyr 100 105
110 Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val
Leu Thr 130 135 140 Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr
Ala Thr Ile Thr 145 150 155 160 Cys Gly Gly Asp Phe Ala Thr Lys Asn
Val Asn Trp Tyr Gln Arg Lys 165 170 175 Pro Gly Gln Ala Pro Val Thr
Val Ile Tyr Tyr Asn Thr Glu Arg Pro 180 185 190 Ser Ala Ile Pro Glu
Arg Phe Ser Gly Ser Asn Thr Gly Ser Thr Ala 195 200 205 Thr Leu Thr
Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 210 215 220 Cys
Gln Val Trp Asp Ser Phe Thr Asp His Arg Leu Phe Gly Gly Gly 225 230
235 240 Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 68
<211> LENGTH: 762 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(762) <223> OTHER INFORMATION:
Polynucleotide encoding RGB0101 scFv protein <400> SEQUENCE:
68 gag gtg cag ctg gtg gag act ggg gga ggc gtg gtc cag cct ggg agg
48 Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15 tcc cag aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc
gac tat 96 Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Asp Tyr 20 25 30 gct atg cac tgg gtc cgc cag gct cca ggg aag ggg
ctg gag tgg gtc 144 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 tca gct att agt ggt agt ggt ggt agc aca
tac tac gca gac tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr
Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga
gac aat tcc aag aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg
aga gcc gag gac acg gcc gta tat tac tgt 288 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aaa gga atc
agg tat tac tat gat agt agt ggt tat tac gat ggg 336 Ala Lys Gly Ile
Arg Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Asp Gly 100 105 110 tac tac
tac tac ggt atg gac gtc tgg ggc caa ggg acc acg gtc acc 384 Tyr Tyr
Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125
gtc tcc tca ggt gga ggc ggt tca ggc gga ggt ggc agc ggc ggt ggc 432
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 130
135 140 gga tcg tct gag ctg act cag gac cct gct gtg tct gtg gcc ttg
gga 480 Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu
Gly 145 150 155 160 cag aca gtc agg atc act tgc caa gga gac agt ctc
aga agc tat tac 528 Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu
Arg Ser Tyr Tyr 165 170 175 aca aac tgg ttc cag cag agg cca gga cag
gcc cct cta ctt gtc gtc 576 Thr Asn Trp Phe Gln Gln Arg Pro Gly Gln
Ala Pro Leu Leu Val Val 180 185 190 tat gct aaa aat aag cgg ccc tca
ggg atc cca gac cga ttc tct ggc 624 Tyr Ala Lys Asn Lys Arg Pro Ser
Gly Ile Pro Asp Arg Phe Ser Gly 195 200 205 tcc agc tca gga aac aca
gct tcc ttg acc atc act ggg gct cag gcg 672 Ser Ser Ser Gly Asn Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 210 215 220 gaa gat gag gct
gac tat tac tgt cat tcc cgg gac agc agt ggt aac 720 Glu Asp Glu Ala
Asp Tyr Tyr Cys His Ser Arg Asp Ser Ser Gly Asn 225 230 235 240 cat
gtg ctt ttc ggc gga ggg acc aag ctg acc gtc cta ggt 762 His Val Leu
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250 <210> SEQ
ID NO 69 <211> LENGTH: 753 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(753) <223> OTHER
INFORMATION: Polynucleotide encoding RGB0102 scFv protein
<400> SEQUENCE: 69 cag gtg cag ctg gta cag tct ggg gct gag
gtg aag aag cct ggg gcc 48 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 tca gtg aag gtc tcc tgc aag gct
tct gga tac acc ttc acc gac tac 96 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 tat ata cac tgg gtg cga
cag gcc cct gga caa ggg ctt gag tgg atg 144 Tyr Ile His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga tgg atc aac
cct aaa agt ggt gac aca aac tat gca cag aag ttt 192 Gly Trp Ile Asn
Pro Lys Ser Gly Asp Thr Asn Tyr Ala Gln Lys Phe 50 55 60 cag ggc
agg gtc acc atg gcc agg gac acg tcc atg agc acg gcc tcc 240 Gln Gly
Arg Val Thr Met Ala Arg Asp Thr Ser Met Ser Thr Ala Ser 65 70 75 80
gtg gaa ctg aga agg ttg aca tct gac gac acg gcc gtg tat tac tgt 288
Val Glu Leu Arg Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg agg aac tcg ttc gac ttt ggg agt ggc tat ggg ctc ttc tac
cag 336 Ala Arg Asn Ser Phe Asp Phe Gly Ser Gly Tyr Gly Leu Phe Tyr
Gln 100 105 110 tac att atg gac gtc tgg ggc caa gga acc ctg gtc acc
gtc tcc tca 384 Tyr Ile Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser 115 120 125 ggt gga ggc ggt tca ggc gga ggt ggc agc ggc
ggt ggc gga tcg gac 432 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Asp 130 135 140 atc cag atg acc cag tct cca tcc ttc
ctg tct gca tct gta gga gac 480 Ile Gln Met Thr Gln Ser Pro Ser Phe
Leu Ser Ala Ser Val Gly Asp 145 150 155 160 aga gtc acc atc act tgc
cgg gcc agt cag ggc att aac aat tat tta 528 Arg Val Thr Ile Thr Cys
Arg Ala Ser Gln Gly Ile Asn Asn Tyr Leu 165 170 175 gcc tgg tat cag
caa aaa cca ggg aga gcc cct aag ctc ctg atc tac 576 Ala Trp Tyr Gln
Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr 180 185 190 gct gca
tcc agt tta caa agt ggg gtc cca tca agg ttc agc ggc agt 624 Ala Ala
Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 195 200 205
gga tct ggc aca gat ttc act ctc acc atc agc agc ctg cag cct gaa 672
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 210
215 220 gat ttt gca act tat tac tgt ctc caa gat tcc gat tat ccc ctc
act 720 Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Asp Tyr Pro Leu
Thr 225 230 235 240 ttc ggc gga ggg acc aag ctg gag atc aaa cgt 753
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 245 250 <210> SEQ
ID NO 70 <211> LENGTH: 765 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(765) <223> OTHER
INFORMATION: Polynucleotide encoding RGB0103 scFv protein
<400> SEQUENCE: 70 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga cat tat cag agt ggt ggc tat gtc tac att acc ttc tat
tac 336 Ala Arg His Tyr Gln Ser Gly Gly Tyr Val Tyr Ile Thr Phe Tyr
Tyr
100 105 110 cct atg gac gtc tgg ggc cag ggc acc ctg gtc acc gtc tcg
agt gga 384 Pro Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Gly 115 120 125 ggc ggc ggt tca ggc gga ggt ggc tct ggc ggt ggc
gga agt gca ctt 432 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Ala Leu 130 135 140 aat ttt atg ctg act cag ccc cac tct gtg
tcg gag tct ccg ggt aag 480 Asn Phe Met Leu Thr Gln Pro His Ser Val
Ser Glu Ser Pro Gly Lys 145 150 155 160 aca gta act ctc tcc tgc acc
cgc tcc agt ggc agc att tca ttc gac 528 Thr Val Thr Leu Ser Cys Thr
Arg Ser Ser Gly Ser Ile Ser Phe Asp 165 170 175 tat gtg cag tgg tat
caa cag cgg ccg ggc agc tcc ccc att ctt gtg 576 Tyr Val Gln Trp Tyr
Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu Val 180 185 190 atc ttt gaa
gat gac caa aga ccc tct ggg gtc cct gat cga ttc tct 624 Ile Phe Glu
Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 195 200 205 ggc
tcc atc gac agt acc tcc aac tct gcc tcc ctc acc atc tct ggc 672 Gly
Ser Ile Asp Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 210 215
220 ctg cag agt gag gac gag ggt gac tac tat tgt cag act tat gat gac
720 Leu Gln Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp Asp
225 230 235 240 aac cgt cag gtg ttc ggc ggg ggg acc aag ctg acc gtc
cta ggt 765 Asn Arg Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
Gly 245 250 255 <210> SEQ ID NO 71 <211> LENGTH: 744
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(744) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0104 scFv protein <400> SEQUENCE: 71 gag gtg cag
ctg ttg gag tct ggg gga gac ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gag gac aga atg aga act
cag ctt gac tcc tgg ggc cgg ggc 336 Ala Arg Glu Asp Arg Met Arg Thr
Gln Leu Asp Ser Trp Gly Arg Gly 100 105 110 acc ctg gtc acc gtc tcg
agt gga ggc ggc ggt tca ggc gga ggt ggc 384 Thr Leu Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc
gga agt gca cag tct gtg ttg acg cag ccg ccc tca 432 Ser Gly Gly Gly
Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser 130 135 140 gtg tct
ggg gcc cca ggg cag agg gtc acc atc tcc tgc act ggg agc 480 Val Ser
Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser 145 150 155
160 agc tcc aac atc ggg gcg gat tat gat gta cac tgg tac caa cac cat
528 Ser Ser Asn Ile Gly Ala Asp Tyr Asp Val His Trp Tyr Gln His His
165 170 175 cca gga aca gcc ccc aga ctc ctc ata tat gat aac acc aat
cgg ccc 576 Pro Gly Thr Ala Pro Arg Leu Leu Ile Tyr Asp Asn Thr Asn
Arg Pro 180 185 190 tca ggg gtc cct gac cga ttc tct ggc tcc aag tct
ggc acc tca gcc 624 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser
Gly Thr Ser Ala 195 200 205 tcc ctg acc atc act ggg ctc cag gct gag
gat gag gct gat tat tac 672 Ser Leu Thr Ile Thr Gly Leu Gln Ala Glu
Asp Glu Ala Asp Tyr Tyr 210 215 220 tgc cag tcc tat gac gcc agt ctg
agt ggt tat gtg gtc ttc ggc gga 720 Cys Gln Ser Tyr Asp Ala Ser Leu
Ser Gly Tyr Val Val Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc
gtc cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ
ID NO 72 <211> LENGTH: 744 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(744) <223> OTHER
INFORMATION: Polynucleotide encoding RGB0106 scFv protein
<400> SEQUENCE: 72 aag gtg cag ctg gtg cag tct ggg gct gag
gtg aag aag cct ggg tcg 48 Lys Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ser 1 5 10 15 tcg gtg agg gtc tcc tgc aag gtc
tct gga gac acc tcc acc tcc tat 96 Ser Val Arg Val Ser Cys Lys Val
Ser Gly Asp Thr Ser Thr Ser Tyr 20 25 30 att atc aac tgg gtg cga
cag gcc cct gga caa ggg ctt gag tgg atg 144 Ile Ile Asn Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga gtg atc atc
cct atg ttt ggt aca aca aat tac gca cag aag ttc 192 Gly Val Ile Ile
Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 gaa gac
aga gtc acg att agc gcg gac gga tcc acg agc aca gtg tac 240 Glu Asp
Arg Val Thr Ile Ser Ala Asp Gly Ser Thr Ser Thr Val Tyr 65 70 75 80
atg gaa ttg agt ggc ctg aaa tcc gag gac acg gcc gta tat tac tgt 288
Met Glu Leu Ser Gly Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg gga tcc gat ttt tgg agt ggt tat gat ggc gag ccc gac gtc
ttt 336 Ala Gly Ser Asp Phe Trp Ser Gly Tyr Asp Gly Glu Pro Asp Val
Phe 100 105 110 gat ctc tgg ggc caa gga acc ctg gtc acc gtc tcc tca
ggc gga ggc 384 Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
Gly Gly Gly 115 120 125 ggt tca ggc gga ggt ggc agc ggc ggt ggt gga
tcg tct gag ctg act 432 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ser Glu Leu Thr 130 135 140 cag gac cct gct gtg tct gtg gcc ttg
gga cag aca gtc agg atc act 480 Gln Asp Pro Ala Val Ser Val Ala Leu
Gly Gln Thr Val Arg Ile Thr 145 150 155 160 tgc caa gga gac agt ctc
aga agc tat tac aca aac tgg ttc cag cag 528 Cys Gln Gly Asp Ser Leu
Arg Ser Tyr Tyr Thr Asn Trp Phe Gln Gln 165 170 175 aag cca gga cag
gcc cct cta ctt gtc gtc tat gct aaa aat aag cgg 576 Lys Pro Gly Gln
Ala Pro Leu Leu Val Val Tyr Ala Lys Asn Lys Arg 180 185 190 ccc tca
ggg atc cca gac cga ttc tct ggc tcc agc tca gga aac aca 624 Pro Ser
Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 195 200 205
gct tcc ttg acc atc act ggg gct cag gcg gaa gat gag gct gac tat 672
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr 210
215 220 tac tgt cat tcc cgg gac agc agt ggt aac cat gtg ctt ttc ggc
gga 720 Tyr Cys His Ser Arg Asp Ser Ser Gly Asn His Val Leu Phe Gly
Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt 744 Gly Thr Lys
Leu Thr Val Leu Gly 245 <210> SEQ ID NO 73 <211>
LENGTH: 729 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(729) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0110 scFv protein <400> SEQUENCE: 73 gag gtg cag
ctg gtg cag tct ggg gga ggc gtg gtc cag cct ggg agg 48 Glu Val Gln
Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 tcc
ctg aga ctc tcc tgc gca gcc tct gga ttc acc ttc agt agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg
144 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 gca gtt ata tca tat gat gga agt aat aaa tac tat gca gac
tcc gtg 192 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cga ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gct gag gac
acg gct gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aaa gcc tcc acg tat tac gat
ttt tgg ttt gat atc tgg ggc cag 336 Ala Lys Ala Ser Thr Tyr Tyr Asp
Phe Trp Phe Asp Ile Trp Gly Gln 100 105 110 ggg aca atg gtc act gtc
tct tca ggt gga ggc ggt tca ggc gga ggt 384 Gly Thr Met Val Thr Val
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 ggc agc ggc ggt
ggc gga tcg gac atc cag atg acc cag tct cca tcc 432 Gly Ser Gly Gly
Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 130 135 140 ttc ctg
tct gca tct gta gga gac aga gtc acc atc act tgc cgg gcc 480 Phe Leu
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 145 150 155
160 agt cag ggc att aac aat tat tta gcc tgg tat cag caa aaa cca ggg
528 Ser Gln Gly Ile Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly
165 170 175 aga gcc cct aag ctc ctg atc tac gct gca tcc agt tta caa
agt ggg 576 Arg Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln
Ser Gly
180 185 190 gtc cca tca agg ttc agc ggc agt gga tct ggc aca gat ttc
act ctc 624 Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
Thr Leu 195 200 205 acc atc agc agc ctg cag cct gaa gat ttt gca act
tat tac tgt ctc 672 Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
Tyr Tyr Cys Leu 210 215 220 caa gat tcc gat tat ccc ctc act ttc ggc
gga ggg acc aag ctg gag 720 Gln Asp Ser Asp Tyr Pro Leu Thr Phe Gly
Gly Gly Thr Lys Leu Glu 225 230 235 240 atc aaa cgt 729 Ile Lys Arg
<210> SEQ ID NO 74 <211> LENGTH: 744 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(744)
<223> OTHER INFORMATION: Polynucleotide encoding RGB0113 scFv
protein <400> SEQUENCE: 74 ggg gtc cag ctg gtg cag tct ggg
gct gag ggg aag aag cct ggg gcc 48 Gly Val Gln Leu Val Gln Ser Gly
Ala Glu Gly Lys Lys Pro Gly Ala 1 5 10 15 tca gtg aag gtc tcc tgc
aag gct tct ggg ggc aac atc agc agg ttt 96 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Gly Asn Ile Ser Arg Phe 20 25 30 ggt atc aac tgg
gtg cga cag gcc cct gga caa ggg ctt gag tgg atg 144 Gly Ile Asn Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga gtg
atc atc cct atg ttt ggt aca aca aat tac gca cag aag ttc 192 Gly Val
Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60
gaa gac aga gtc acg att agc gcg gac gga tcc acg agc aca gtg tac 240
Glu Asp Arg Val Thr Ile Ser Ala Asp Gly Ser Thr Ser Thr Val Tyr 65
70 75 80 atg gaa ttg agt ggc ctg aaa tcc gag gac acg gcc gta tat
tac tgt 288 Met Glu Leu Ser Gly Leu Lys Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg gga tcc gat ttt tgg agt ggt tat gat ggc gag
ccc gac gtc ttt 336 Ala Gly Ser Asp Phe Trp Ser Gly Tyr Asp Gly Glu
Pro Asp Val Phe 100 105 110 gat ctc tgg ggc cgg gga acc ctg gtc acc
gtc tct tca ggt gga ggc 384 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly 115 120 125 ggt tca ggc gga ggt ggc agc ggc
ggt ggc gga tcg tct gag ctg act 432 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser Glu Leu Thr 130 135 140 cag gac cct gct gtg tct
gtg gcc ttg gga cag aca gtc agg atc act 480 Gln Asp Pro Ala Val Ser
Val Ala Leu Gly Gln Thr Val Arg Ile Thr 145 150 155 160 tgc caa gga
gac agt ctc aga agc tat tac aca aac tgg ttc cag cag 528 Cys Gln Gly
Asp Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gln Gln 165 170 175 aag
cca gga cag gcc cct cta ctt gtc gtc tat gct aaa aat aag cgg 576 Lys
Pro Gly Gln Ala Pro Leu Leu Val Val Tyr Ala Lys Asn Lys Arg 180 185
190 ccc tca gag atc cca gac cga ttc tct ggc tcc agc tca gga aac aca
624 Pro Ser Glu Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr
195 200 205 gct tcc ttg acc atc act ggg gct cag gcg gaa gat gag gct
gac tat 672 Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala
Asp Tyr 210 215 220 tac tgt cat tcc cgg gac agc agt ggt aac cat gtg
ctt ttc ggc gga 720 Tyr Cys His Ser Arg Asp Ser Ser Gly Asn His Val
Leu Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt 744
Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 75
<400> SEQUENCE: 75 000 <210> SEQ ID NO 76 <211>
LENGTH: 747 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(747) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0115 scFv protein <400> SEQUENCE: 76 cag ctg cag
ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg 48 Gln Leu Gln
Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 1 5 10 15 acc
ctg tcc ctc aac tgc gct gta tct ggt gac tcc atc agc agt gga 96 Thr
Leu Ser Leu Asn Cys Ala Val Ser Gly Asp Ser Ile Ser Ser Gly 20 25
30 aat tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gaa tgg
144 Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45 act gga gaa atc tat cat agt ggg acc gcc aac tac aac ccg
tcc ctc 192 Thr Gly Glu Ile Tyr His Ser Gly Thr Ala Asn Tyr Asn Pro
Ser Leu 50 55 60 aag agt cga gtc acc gtg tca gtg gac aag tcc acg
aac cag ttt tcc 240 Lys Ser Arg Val Thr Val Ser Val Asp Lys Ser Thr
Asn Gln Phe Ser 65 70 75 80 ctg aga atg agc tct gtg acc gcc gcg gac
acg gcc gtt tat tac tgt 288 Leu Arg Met Ser Ser Val Thr Ala Ala Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg agg gcc ggc tac tat gat gtg
gga ctc cca ttc gac tac tgg ggc 336 Ala Arg Ala Gly Tyr Tyr Asp Val
Gly Leu Pro Phe Asp Tyr Trp Gly 100 105 110 aaa gga acc ctg gtc acc
gtc tcg agt gga ggc ggc ggt tca ggc gga 384 Lys Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 ggt ggc tct ggc
ggt ggc gga agt gca cag gct gtg ctg act cag ccg 432 Gly Gly Ser Gly
Gly Gly Gly Ser Ala Gln Ala Val Leu Thr Gln Pro 130 135 140 tcc tca
gta tct ggg gcc cca ggg cag agg gtc acc ctc tcc tgc act 480 Ser Ser
Val Ser Gly Ala Pro Gly Gln Arg Val Thr Leu Ser Cys Thr 145 150 155
160 ggg agc agc tcc aac atc ggg gca ggt tct gag ttc cac tgg tac cag
528 Gly Ser Ser Ser Asn Ile Gly Ala Gly Ser Glu Phe His Trp Tyr Gln
165 170 175 cag gtt cca gga aca gcc ccc aag ctc ctc atc ttt ggt aac
acc aat 576 Gln Val Pro Gly Thr Ala Pro Lys Leu Leu Ile Phe Gly Asn
Thr Asn 180 185 190 cgg ccc tgg gga gtc cct gac cga ttc tct ggc tcc
aag tct ggc acc 624 Arg Pro Trp Gly Val Pro Asp Arg Phe Ser Gly Ser
Lys Ser Gly Thr 195 200 205 tca gcc tcc ctg gcc atc act ggg ctc cag
gct gag gat gag gct gat 672 Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln
Ala Glu Asp Glu Ala Asp 210 215 220 tat tat tgc cag tcc tat gac agc
agc ctg agt gct tat gtc ttc gga 720 Tyr Tyr Cys Gln Ser Tyr Asp Ser
Ser Leu Ser Ala Tyr Val Phe Gly 225 230 235 240 act ggg acc aag gtc
acc gtc cta ggt 747 Thr Gly Thr Lys Val Thr Val Leu Gly 245
<210> SEQ ID NO 77 <211> LENGTH: 741 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(741)
<223> OTHER INFORMATION: Polynucleotide encoding RGB0118 scFv
protein <400> SEQUENCE: 77 gag gtc cag ctg gtg cag tct ggg
gct gag gtg aag aag cct ggg gcc 48 Glu Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 tca gtg aag gtc tcc tgc
aag gct tct gga tac acc ttc acc gac tac 96 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 tat atg cac tgg
gtg cga cag gcc cct gga caa ggg ctt gag tgg atg 144 Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga tgg
atc aac cct aac agt ggt ggc aca aac tat gca cag aag ttt 192 Gly Trp
Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60
cag ggc agg gtc acc atg acc agg gac acg tcc atc agc aca gcc tac 240
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65
70 75 80 atg gag ctg agc agg ctg aga tct gac gac acg gcc gtg tat
ttc tgt 288 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr
Phe Cys 85 90 95 gcg aga gat ctt ctc tct tat ttc tat gat agt agt
ggt tac ctc gac 336 Ala Arg Asp Leu Leu Ser Tyr Phe Tyr Asp Ser Ser
Gly Tyr Leu Asp 100 105 110 aac tgg ggc caa ggg aca atg gtc acc gtc
tcg agt ggt gga ggc ggt 384 Asn Trp Gly Gln Gly Thr Met Val Thr Val
Ser Ser Gly Gly Gly Gly 115 120 125 tca ggc gga ggt ggc agc ggc ggt
ggc gga tcg tct gag ctg act cag 432 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ser Glu Leu Thr Gln 130 135 140 gac act gct gtg tct gtg
gcc ttg gga cag aca gtc agg atc act tgc 480 Asp Thr Ala Val Ser Val
Ala Leu Gly Gln Thr Val Arg Ile Thr Cys 145 150 155 160 caa gga gac
agt ctc aga agc tat tac aca aac tgg ttc cag cag aag 528 Gln Gly Asp
Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gln Gln Lys 165 170 175 cca
gga cag gcc cct cta ctt gtc gtc tat gct aaa aat aag cgg ccc 576 Pro
Gly Gln Ala Pro Leu Leu Val Val Tyr Ala Lys Asn Lys Arg Pro 180 185
190 tca ggg atc cca gac cga ttc tct ggc tcc agc tca gga aac aca gct
624 Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala
195 200 205 tcc ttg acc atc act ggg gct cag gcg gaa gat gag gct gac
tat tac 672 Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp
Tyr Tyr 210 215 220 tgt aac tcc cgg gac agc agt ggt aac cat gtg gta
ttc ggc gga ggg 720 Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val
Phe Gly Gly Gly 225 230 235 240 acc aag ctg acc gtc cta ggt 741
Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 78
<211> LENGTH: 744 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(744) <223> OTHER INFORMATION:
Polynucleotide encoding RGB0128 scFv protein <400> SEQUENCE:
78 gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg
48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc
agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg
ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 tca gct att agt ggt agt ggt ggt agc aca
tac tac gca gac tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr
Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga
gac aat tcc aag aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg
aga gcc gag gac acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gca aga gag gat
cct tgg agt gac gct ttt gat ttg tgg ggc cgg gga 336 Ala Arg Glu Asp
Pro Trp Ser Asp Ala Phe Asp Leu Trp Gly Arg Gly 100 105 110 acc ctg
gtc acc gtc tcg agt gga ggc ggc ggt tca ggc gga ggt ggc 384 Thr Leu
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125
tct ggc ggt ggc gga agt gca ctt aat ttt atg ctg act cag ccc cac 432
Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 130
135 140 tct gtg tcg gag tct ccg ggg aag acg gta acc att tcc tgc acc
ggc 480 Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr
Gly 145 150 155 160 agc agt ggc agc att gcc agc aac tat gtg cag tgg
tac cag cag cgc 528 Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp
Tyr Gln Gln Arg 165 170 175 ccg ggc agt gcc ccc gcc act gtg atc tat
gag gat aac caa aga ccc 576 Pro Gly Ser Ala Pro Ala Thr Val Ile Tyr
Glu Asp Asn Gln Arg Pro 180 185 190 tct ggg gtc cct gat cgg ttc tct
ggc tcc atc gac agc tcc tcc aac 624 Ser Gly Val Pro Asp Arg Phe Ser
Gly Ser Ile Asp Ser Ser Ser Asn 195 200 205 tct gcc tcc ctc acc atc
tct gac ctg aag act gag gac gag gct gac 672 Ser Ala Ser Leu Thr Ile
Ser Asp Leu Lys Thr Glu Asp Glu Ala Asp 210 215 220 tac tac tgt cag
tct ttt gat aac agc aaa tat gtg gta ttc ggc gga 720 Tyr Tyr Cys Gln
Ser Phe Asp Asn Ser Lys Tyr Val Val Phe Gly Gly 225 230 235 240 ggg
acc aag ctg acc gtc cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 79 <211> LENGTH: 756 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(756)
<223> OTHER INFORMATION: Polynucleotide encoding RGB0129 scFv
protein <400> SEQUENCE: 79 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aaa ggg cct gat tgt act aat ggt gta tgc tat
ctc ccc ttt gac 336 Ala Lys Gly Pro Asp Cys Thr Asn Gly Val Cys Tyr
Leu Pro Phe Asp 100 105 110 tac tgg ggc agg ggc acc ctg gtc acc gtc
tcg agt gga ggc ggc ggt 384 Tyr Trp Gly Arg Gly Thr Leu Val Thr Val
Ser Ser Gly Gly Gly Gly 115 120 125 tca ggc gga ggt ggc tct ggc ggt
ggc gga agt gca ctt aat ttt atg 432 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Leu Asn Phe Met 130 135 140 ctg act cag ccc cac tct
gtg tcg gag tct ccg ggt aag aca gta act 480 Leu Thr Gln Pro His Ser
Val Ser Glu Ser Pro Gly Lys Thr Val Thr 145 150 155 160 ctc tcc tgc
acc cgc tcc agt ggc agc att tca ttc gac tat gtg cag 528 Leu Ser Cys
Thr Arg Ser Ser Gly Ser Ile Ser Phe Asp Tyr Val Gln 165 170 175 tgg
tat caa cag cgg ccg ggc agc tcc ccc att ctt gtg atc ttt gaa 576 Trp
Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ile Leu Val Ile Phe Glu 180 185
190 gat gac caa aga ccc tct ggg gtc cct gat cga ttc tct ggc tcc atc
624 Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile
195 200 205 gac agt acc tcc aac tct gcc tcc ctc acc atc tct ggc ctg
cag agt 672 Asp Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu
Gln Ser 210 215 220 gag gac gag ggt gac tac tat tgt cag act tat gat
gac aac cgt cag 720 Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp
Asp Asn Arg Gln 225 230 235 240 gtg ttc ggc ggg ggg acc aag ctg acc
gtc cta ggt 756 Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245
250 <210> SEQ ID NO 80 <211> LENGTH: 738 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(738)
<223> OTHER INFORMATION: Polynucleotide encoding RGB0137 scFv
protein <400> SEQUENCE: 80 gag gtg cag ctg gtg cag tct ggg
gct gag gtg gag aag cct ggg gcc 48 Glu Val Gln Leu Val Gln Ser Gly
Ala Glu Val Glu Lys Pro Gly Ala 1 5 10 15 tca gtg aaa gtc tcc tgc
aag gtt tct ggc tac acc ttc acc ggc gac 96 Ser Val Lys Val Ser Cys
Lys Val Ser Gly Tyr Thr Phe Thr Gly Asp 20 25 30 tat atg cac tgg
gtg cga cag gcc cct gga caa gga ctt gag tgg atg 144 Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga agg
atc gac cct aag tat ggt gac aca aac tat gca cag aag ttt 192 Gly Arg
Ile Asp Pro Lys Tyr Gly Asp Thr Asn Tyr Ala Gln Lys Phe 50 55 60
cag ggc agg gtc acc atg acc agg gac acg tcc atc agc aca gtc tac 240
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 65
70 75 80 atg gag ctg agc agg ctg aga tct gac gac acg gcc cta tat
ttc tgt 288 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Leu Tyr
Phe Cys 85 90 95 gcg aca gat aac agt ggg tta tat gat gct ttt gac
aag tgg ggg aaa 336 Ala Thr Asp Asn Ser Gly Leu Tyr Asp Ala Phe Asp
Lys Trp Gly Lys 100 105 110 ggg acc acg gtc acc gtc tcg agt ggt gga
ggc ggt tca ggc gga ggt 384 Gly Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 ggc agc ggc ggt ggc gga tcg cag
tct gtg ctg act cag cct gcc tcc 432 Gly Ser Gly Gly Gly Gly Ser Gln
Ser Val Leu Thr Gln Pro Ala Ser 130 135 140 gtg tct ggg tct cct gga
cag tcg atc acc atc tcc tgc act gga acc 480 Val Ser Gly Ser Pro Gly
Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr 145 150 155 160 agc agt gac
gtt ggt ggt tat aac tat gtc tcc tgg tac caa caa cac 528 Ser Ser Asp
Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His 165 170 175 cca
ggc aaa gcc ccc aaa ctc atg att tat gag ggc agt aag cgg ccc 576 Pro
Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Gly Ser Lys Arg Pro 180 185
190 tca ggg gtt tct aat cgc ttc tct ggc tcc aag tct ggc aac acg gcc
624 Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala
195 200 205 tcc ctg aca atc tct agg ctc cag gct gag gac gag gct gat
tat tac 672 Ser Leu Thr Ile Ser Arg Leu Gln Ala Glu Asp Glu Ala Asp
Tyr Tyr 210 215 220 tgc agc tca tat aca acc agg agc act cga gtt ttc
ggc gga ggg acc 720 Cys Ser Ser Tyr Thr Thr Arg Ser Thr Arg Val Phe
Gly Gly Gly Thr 225 230 235 240 aag ctg acc gtc cta ggt 738 Lys Leu
Thr Val Leu Gly 245 <210> SEQ ID NO 81 <211> LENGTH:
747 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(747) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0146 scFv protein <400> SEQUENCE: 81 cag gta cag
ctg cag cag tca ggc cca aga cta gtg aag cct tca cag 48 Gln Val Gln
Leu Gln Gln Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 1 5 10 15
acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc aga ggg 96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Arg Gly 20
25 30 ggt tac tac tgg agc tgg atc cgc cag ctc cca ggg aag ggc ctg
gag 144 Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu
Glu 35 40 45 tgg att ggg tac atc tat cac agt ggg agc acc tac tac
aac ccg ccc 192 Trp Ile Gly Tyr Ile Tyr His Ser Gly Ser Thr Tyr Tyr
Asn Pro Pro 50 55 60 ctc aag agt cga gtt acc atg tca gta gac acg
tct aag aat cag ttc 240 Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr
Ser Lys Asn Gln Phe 65 70 75 80 tcc ctg aac ctg agc tct gtg act gcc
gcg gac acg gcc gtt tat tac 288 Ser Leu Asn Leu Ser Ser Val Thr Ala
Ala Asp Thr Ala Val Tyr Tyr 85 90 95 tgt gcg aga gaa aag ggc ggc
gac tgg gag caa ctg gtc ttt gac cac 336 Cys Ala Arg Glu Lys Gly Gly
Asp Trp Glu Gln Leu Val Phe Asp His 100 105 110 tgg ggc aga ggg aca
atg gtc acc gtc tct tca ggt gga ggc ggt tca 384 Trp Gly Arg Gly Thr
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 ggc gga ggt
ggc agc ggc ggt ggc gga tcg cag tct gtg ttg acg cag 432 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln 130 135 140 ccg
ccc tca gtg tct gcg gcc cca gga cag aag gtc acc att tcc tgc 480 Pro
Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile Ser Cys 145 150
155 160 tct gga agc acc tcc aac att ggg aat aat tat gtc tcc tgg tac
caa 528 Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp Tyr
Gln 165 170 175 cag cac cca ggc aaa gcc ccc aaa ctc atg att tat gat
gtc agt aag 576 Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp
Val Ser Lys 180 185 190 cgg ccc tca ggg gtc cct gac cga ttc tct ggc
tcc aag tct ggc aac 624 Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly
Ser Lys Ser Gly Asn 195 200 205 tca gcc tcc ctg gac atc agt ggg ctc
cag tct gag gat gag gct gat 672 Ser Ala Ser Leu Asp Ile Ser Gly Leu
Gln Ser Glu Asp Glu Ala Asp 210 215 220 tat tac tgt gca gca tgg gat
gac agc ctg agt gaa ttt ctc ttc gga 720 Tyr Tyr Cys Ala Ala Trp Asp
Asp Ser Leu Ser Glu Phe Leu Phe Gly 225 230 235 240 act ggg acc aag
ctg acc gtc cta ggt 747 Thr Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 82 <211> LENGTH: 747 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(747)
<223> OTHER INFORMATION: Polynucleotide encoding RGB0153 scFv
protein <400> SEQUENCE: 82 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga ggt gcg gga gct act cca ttt aat gct ttt
gat atc tgg ggg 336 Ala Arg Gly Ala Gly Ala Thr Pro Phe Asn Ala Phe
Asp Ile Trp Gly 100 105 110 cgg ggg acc acg gtc acc gtc tcg agt gga
ggc ggc ggt tca ggc gga 384 Arg Gly Thr Thr Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly 115 120 125 ggt ggc tct ggc ggt ggc gga agt
gca ctt aat ttt atg ctg act cag 432 Gly Gly Ser Gly Gly Gly Gly Ser
Ala Leu Asn Phe Met Leu Thr Gln 130 135 140 ccc cac tct gtg tcg gag
tct ccg ggt aag aca gta act ctc tcc tgc 480 Pro His Ser Val Ser Glu
Ser Pro Gly Lys Thr Val Thr Leu Ser Cys 145 150 155 160 acc cgc tcc
agt ggc agt att tca ttc gac tat gtg cag tgg tat caa 528 Thr Arg Ser
Ser Gly Ser Ile Ser Phe Asp Tyr Val Gln Trp Tyr Gln 165 170 175 cag
cgg ccg ggc agc tcc ccc att ctt gtg atc ttt gaa gat gac caa 576 Gln
Arg Pro Gly Ser Ser Pro Ile Leu Val Ile Phe Glu Asp Asp Gln 180 185
190 aga ccc tct ggg gtc cct gat cga ttc tct ggc tcc atc gac agt acc
624 Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Thr
195 200 205 tcc aac tct gcc tcc ctc acc atc tct ggc ctg cag agt gag
gac gag 672 Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu
Asp Glu 210 215 220 ggt gac tac tat tgt cag act tat gat gac aac cgt
cag gtg ttc ggc 720 Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp Asp Asn Arg
Gln Val Phe Gly 225 230 235 240 ggg ggg acc aag gtc acc gtc cta ggt
747 Gly Gly Thr Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO
83 <211> LENGTH: 741 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(741) <223> OTHER
INFORMATION: Polynucleotide encoding RGB0163 scFv protein
<400> SEQUENCE: 83 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aca gat cct tac tat gat agt agt ggt tat tac ccc ttt agc
tac 336 Ala Thr Asp Pro Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro Phe Ser
Tyr 100 105 110 tgg ggg cgg ggg acc acg gtc acc gtc tcg agt gga ggc
ggc ggt tca 384 Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Gly Ser 115 120 125 ggc gga ggt ggc tct ggc ggt ggc gga agt gca
cag tct gtg ctg acg 432 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
Gln Ser Val Leu Thr 130 135 140 cag ccg ccc tca gtg tca gtg gcc cca
gga aag acg gcc aca att acc 480 Gln Pro Pro Ser Val Ser Val Ala Pro
Gly Lys Thr Ala Thr Ile Thr 145 150 155 160 tgt ggg gga gac ttt gca
act aaa aat gtg aat tgg tac caa cgg aag 528 Cys Gly Gly Asp Phe Ala
Thr Lys Asn Val Asn Trp Tyr Gln Arg Lys 165 170 175 ccg ggc cag gcc
cct gtg acg gtc atc tat tat gac acc gag cgg ccc 576 Pro Gly Gln Ala
Pro Val Thr Val Ile Tyr Tyr Asp Thr Glu Arg Pro 180 185 190 tca gcg
atc cct gag cgc ttc tct ggc tcc aac act ggg tcc acg gcc 624 Ser Ala
Ile Pro Glu Arg Phe Ser Gly Ser Asn Thr Gly Ser Thr Ala 195 200 205
acc ctg acc atc agc agg gtc gaa gcc ggg gat gag gcc gac tat tat 672
Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 210
215 220 tgt cag gtg tgg gat agt ttt act gat cat cgg ctg ttc ggc gga
ggg 720 Cys Gln Val Trp Asp Ser Phe Thr Asp His Arg Leu Phe Gly Gly
Gly 225 230 235 240 acc aag ctg acc gtc cta ggt 741 Thr Lys Leu Thr
Val Leu Gly 245 <210> SEQ ID NO 84 <211> LENGTH: 759
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(759) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0165 scFv protein <400> SEQUENCE: 84 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg gga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95
gcg acg ggg ggt agt ggt tcc ccc gta tac tac tat tac cac tac ttg 336
Ala Thr Gly Gly Ser Gly Ser Pro Val Tyr Tyr Tyr Tyr His Tyr Leu 100
105 110 gac gtc tgg ggc cga ggc acc ctg gtc acc gtc tcg agt gga ggc
ggc 384 Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly
Gly 115 120 125 ggt tca ggc gga ggt ggc tct ggc ggt ggc gga agt gca
ctt aat ttt 432 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
Leu Asn Phe 130 135 140 atg ctg act cag ccc cac tct gtg tcg gag tct
ccg ggt aag aca gta 480 Met Leu Thr Gln Pro His Ser Val Ser Glu Ser
Pro Gly Lys Thr Val 145 150 155 160 act ctc tcc tgc acc cgc tcc agt
ggc agc att tca ttc gac tat gtg 528 Thr Leu Ser Cys Thr Arg Ser Ser
Gly Ser Ile Ser Phe Asp Tyr Val 165 170 175 cag tgg tat caa cag cgg
ccg ggc agc tcc ccc att ctt gtg atc ttt 576 Gln Trp Tyr Gln Gln Arg
Pro Gly Ser Ser Pro Ile Leu Val Ile Phe 180 185 190 gaa gat gac caa
aga ccc tct ggg gtc cct gat cga ttc tct ggc tcc 624 Glu Asp Asp Gln
Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 195 200 205 atc gac
agt acc tcc aac tct gcc tcc ctc acc atc tct ggc ctg cag 672 Ile Asp
Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln 210 215 220
agt gag gac gag ggt gac tac tat tgt cag act tat gat gac aac cgt 720
Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp Asp Asn Arg 225
230 235 240 cag gtg ttc ggc ggg ggg acc aag ctg acc gtc cta ggt 759
Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250
<210> SEQ ID NO 85 <211> LENGTH: 744 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(744)
<223> OTHER INFORMATION: Polynucleotide encoding RGB0174 scFv
protein <400> SEQUENCE: 85 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg agt gac tct gat agt agt gat tat tac tat ttt
gac tct tgg ggc 336 Ala Ser Asp Ser Asp Ser Ser Asp Tyr Tyr Tyr Phe
Asp Ser Trp Gly 100 105 110 cag ggg aca atg gtc acc gtc tcg agt gga
ggc ggc ggt tca ggc gga 384 Gln Gly Thr Met Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly 115 120 125 ggt ggc tct ggc ggt ggc gga agt
gca cag tct gtg ctg act cag cca 432 Gly Gly Ser Gly Gly Gly Gly Ser
Ala Gln Ser Val Leu Thr Gln Pro 130 135 140 ccc tca gcg tct ggg acc
ccc ggg cag agg gtc acc atc tct tgt tct 480 Pro Ser Ala Ser Gly Thr
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 145 150 155 160 gga agc agc
tcc aat atc gga ttt aat gat gtg tac tgg tat cag cag 528 Gly Ser Ser
Ser Asn Ile Gly Phe Asn Asp Val Tyr Trp Tyr Gln Gln 165 170 175 ctc
cca gga ttg gcc ccc aaa ctc ctc atc tat agt aat aat cag cgg 576 Leu
Pro Gly Leu Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg 180 185
190 ccc tca ggg gtc cct gac cga ttc tct ggc tcc gag tct ggc acc tca
624 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Glu Ser Gly Thr Ser
195 200 205 gcc tcc ctg gcc atc agt ggg ctc cgg tcc gag gat gag gct
gat tat 672 Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala
Asp Tyr 210 215 220 tac tgt gca aca tgg gat gac agc ctg agt gcc ccg
gtg ttc ggc gga 720 Tyr Cys Ala Thr Trp Asp Asp Ser Leu Ser Ala Pro
Val Phe Gly Gly 225 230 235 240 ggg acc aag gtc acc gtc cta ggt 744
Gly Thr Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO 86
<211> LENGTH: 753 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(753) <223> OTHER INFORMATION:
Polynucleotide encoding RGB0185 scFv protein <400> SEQUENCE:
86 cag gtg cag ctg gta cag tct ggg gct gag gtg aag aag cct ggg gcc
48 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 tca gtg aag gtc tcc tgc aag gct tct gga tac acc ttc acc
gac tac 96 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Asp Tyr 20 25 30 tat ata cac tgg gtg cga cag gcc cct gga caa ggg
ctt gag tgg atg 144 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Met 35 40 45 gga tgg atc aac cct aaa agt ggt gac aca
aac tat gca cag aag ttt 192 Gly Trp Ile Asn Pro Lys Ser Gly Asp Thr
Asn Tyr Ala Gln Lys Phe 50 55 60 cag ggc agg gtc acc atg gcc agg
gac acg tcc atg agc acg gcc tcc 240 Gln Gly Arg Val Thr Met Ala Arg
Asp Thr Ser Met Ser Thr Ala Ser 65 70 75 80 gtg gaa ctg aga agg ttg
aca tct gac gac acg gcc gtg tat tac tgt 288 Val Glu Leu Arg Arg Leu
Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg agg aac tcg
ttc gac ttt ggg agt ggc tat ggg ctc ttc tac cag 336 Ala Arg Asn Ser
Phe Asp Phe Gly Ser Gly Tyr Gly Leu Phe Tyr Gln 100 105 110 tac att
atg gac gtc tgg ggc caa gga acc ctg gtc acc gtc tcc tca 384 Tyr Ile
Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125
ggt gga ggc ggt tca ggc gga ggt ggc agc ggc ggt ggc gga tcg gac 432
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 130
135 140 atc cag atg acc cag tct cca tcc ttc ctg tct gca tct gta gga
gac 480 Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
Asp 145 150 155 160 aga gtc acc atc act tgc cgg gcc agt cag ggc att
aac aat tat tta 528 Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile
Asn Asn Tyr Leu 165 170 175 gcc tgg tat cag caa aaa cca ggg aga gcc
cct aag ctc ctg atc tac 576 Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala
Pro Lys Leu Leu Ile Tyr 180 185 190 gct gca tcc agt tta caa agt ggg
gtc cca tca agg ttc agc ggc agt 624 Ala Ala Ser Ser Leu Gln Ser Gly
Val Pro Ser Arg Phe Ser Gly Ser 195 200 205 gga tct ggc aca gat ttc
act ctc acc atc agc agc ctg cag cct gaa 672 Gly Ser Gly Thr Asp Phe
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 210 215 220 gat ttt gca act
tat tac tgt ctc caa gat tcc gat tat ccc ctc act 720 Asp Phe Ala Thr
Tyr Tyr Cys Leu Gln Asp Ser Asp Tyr Pro Leu Thr 225 230 235 240 ttc
ggc gga ggg acc aag ctg acc gtc cta ggt 753 Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu Gly 245 250 <210> SEQ ID NO 87 <211>
LENGTH: 759 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(759) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0187 scFv protein <400> SEQUENCE: 87 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gat tcg tgt ccg tat tgt
agt acc aac agc ggc tcc ttt gac 336 Ala Arg Asp Ser Cys Pro Tyr Cys
Ser Thr Asn Ser Gly Ser Phe Asp 100 105 110 tac tgg ggc caa ggg aca
atg gtc acc gtc tcg agt gga ggc ggc ggt 384 Tyr Trp Gly Gln Gly Thr
Met Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125 tca ggc gga ggt
ggc tct ggc ggt ggc gga agt gca ctt aat ttt atg 432 Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met 130 135 140 ctg act
cag ccc cac tct gtg tcg gag tct ccg ggg aag acg gtc acc 480 Leu Thr
Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr 145 150 155
160 atc tcc tgc acc cgc acc agt ggg aac att gcc ggc tac ttt gtg cag
528 Ile Ser Cys Thr Arg Thr Ser Gly Asn Ile Ala Gly Tyr Phe Val Gln
165 170 175
tgg tac cag cag cgc ccg ggc agt tcc ccc acc act gtg atc tat gag 576
Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu 180
185 190 gat tac caa cga ccc tct ggg gtc cct gat cgg ttc tct ggc tcc
atc 624 Asp Tyr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser
Ile 195 200 205 gac agg tcc tcc aac tct gcc tcc ctc acc atc tct gga
ctg aag cct 672 Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
Leu Lys Pro 210 215 220 gac gac gag gct gac tac tat tgt cag tct tat
gat gac acc tct caa 720 Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr
Asp Asp Thr Ser Gln 225 230 235 240 ggt gtg ttc ggc gca ggg acc aag
ctg acc gtc cta ggt 759 Gly Val Phe Gly Ala Gly Thr Lys Leu Thr Val
Leu Gly 245 250 <210> SEQ ID NO 88 <211> LENGTH: 744
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(744) <223> OTHER INFORMATION: Polynucleotide
encoding RGB0194 scFv protein <400> SEQUENCE: 88 gag gtg cag
ctg gtg gag tct ggg gct gaa gtg aag aag cct ggg tcc 48 Glu Val Gln
Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 tcg
gtg aag gtc tcc tgc aag gct tct gga ggc acc ctc agc agg ttt 96 Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Arg Phe 20 25
30 ggt atc aac tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg
144 Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45 ggg gtg atc atc cct atg ttt ggt aca aca aat tac gca cag
aag ttc 192 Gly Val Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln
Lys Phe 50 55 60 gaa gac aga gtc acg att agc gcg gac gga tcc acg
agc aca gtg tac 240 Glu Asp Arg Val Thr Ile Ser Ala Asp Gly Ser Thr
Ser Thr Val Tyr 65 70 75 80 atg gaa ttg agt ggc ctg aag tcc gag gac
acg gcc gtt tat tac tgt 288 Met Glu Leu Ser Gly Leu Lys Ser Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg gga tca gat ttt tgg agt ggt
tat gat ggc gag ccc gac gtc ttt 336 Ala Gly Ser Asp Phe Trp Ser Gly
Tyr Asp Gly Glu Pro Asp Val Phe 100 105 110 gat ctc tgg ggc cga ggc
acc ctg gtc acc gtc tcg agt ggt gga ggc 384 Asp Leu Trp Gly Arg Gly
Thr Leu Val Thr Val Ser Ser Gly Gly Gly 115 120 125 ggt tca ggc gga
ggt ggc agc ggc ggt ggc gga tcg tct gag ctg act 432 Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr 130 135 140 cag gac
cct gct gcg tct gtg gcc ttg gga cag aca gtc agg atc act 480 Gln Asp
Pro Ala Ala Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr 145 150 155
160 tgc caa gga gac agt ctc aga agc tat tac aca aac tgg ttc cag cag
528 Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gln Gln
165 170 175 aag cca gga cag gcc cct cta ctt gtc gtc tat gct aaa aat
aag cgg 576 Lys Pro Gly Gln Ala Pro Leu Leu Val Val Tyr Ala Lys Asn
Lys Arg 180 185 190 ccc tca ggg atc cca gac cga ttc tct ggc tcc agc
tca ggg aac aca 624 Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser
Ser Gly Asn Thr 195 200 205 gct tcc ttg acc atc act ggg gct cag gcg
gaa gat gag gct gac tat 672 Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala
Glu Asp Glu Ala Asp Tyr 210 215 220 tac tgt cat tcc cgg gac agc agt
ggt aac cat gtg ctt ttc ggc gga 720 Tyr Cys His Ser Arg Asp Ser Ser
Gly Asn His Val Leu Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc
gtc cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ
ID NO 89 <211> LENGTH: 750 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(750) <223> OTHER
INFORMATION: Polynucleotide encoding RGC0102 scFv protein
<400> SEQUENCE: 89 cag gtg cag ctg cag gag tcc ggc cca gga
ctg gtg aag cct tcg ggg 48 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
Leu Val Lys Pro Ser Gly 1 5 10 15 acc ctg tcc ctc acc tgc gct gtc
tct ggt ggc tcc atc agc agt agt 96 Thr Leu Ser Leu Thr Cys Ala Val
Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 aac tac tgg agt tgg gtc
cgc cag ccc cca ggg aag ggg ctg gag tgg 144 Asn Tyr Trp Ser Trp Val
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 att ggg gag atc
tat cat gat ggg agc acc aac tac aac ccg tcc ctc 192 Ile Gly Glu Ile
Tyr His Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu 50 55 60 aag agt
cga gtc acc atg tca gca gac aag tcc aag aac cag ttc tcc 240 Lys Ser
Arg Val Thr Met Ser Ala Asp Lys Ser Lys Asn Gln Phe Ser 65 70 75 80
ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt 288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga gat tcc ccc tcg tat agc agt ggc tgg tac tct gac tac
tgg 336 Ala Arg Asp Ser Pro Ser Tyr Ser Ser Gly Trp Tyr Ser Asp Tyr
Trp 100 105 110 ggc aga ggc acc ctg gtc acc gtc tcg agt gga ggc ggc
ggt tca ggc 384 Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125 gga ggt ggc tct ggc ggt ggc gga agt gca cag
tct gtg ctg act cag 432 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln
Ser Val Leu Thr Gln 130 135 140 cca ccc tca gcg tct ggg acc ccc ggg
cag agg gtc acc atc tct tgt 480 Pro Pro Ser Ala Ser Gly Thr Pro Gly
Gln Arg Val Thr Ile Ser Cys 145 150 155 160 tct gga agc agc tcc aac
atc gga agt aat act gta aac tgg tac cag 528 Ser Gly Ser Ser Ser Asn
Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln 165 170 175 caa ctc cca gga
acg gcc ccc aaa ctc ctc atc ttt agt aat aat cag 576 Gln Leu Pro Gly
Thr Ala Pro Lys Leu Leu Ile Phe Ser Asn Asn Gln 180 185 190 cgg ccc
tca ggg gtc cct gac cga ttc tct ggc tcc aag tct ggc acc 624 Arg Pro
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 195 200 205
tca gcc tcc ctg gcc atc agt ggg ctc cag tct gag gat gag gct gtt 672
Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Val 210
215 220 tat tac tgt gca gcg tgg gat gac agc ctg act ggt ttt tat gtc
ttc 720 Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Thr Gly Phe Tyr Val
Phe 225 230 235 240 gga gct ggg acc aag gtc acc gtc cta ggt 750 Gly
Ala Gly Thr Lys Val Thr Val Leu Gly 245 250 <210> SEQ ID NO
90 <211> LENGTH: 726 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(726) <223> OTHER
INFORMATION: Polynucleotide encoding RGC0104 scFv protein
<400> SEQUENCE: 90 gag gtg cag ctg gtg cag tct ggg gct gag
gtg agg aag cct ggg tcc 48 Glu Val Gln Leu Val Gln Ser Gly Ala Glu
Val Arg Lys Pro Gly Ser 1 5 10 15 tca gtg aag gtc tcc tgc acg acc
tct gaa aac acc ttt agg agg tct 96 Ser Val Lys Val Ser Cys Thr Thr
Ser Glu Asn Thr Phe Arg Arg Ser 20 25 30 agt ttc agt tgg cta cgc
cag gcc cct gga caa ggt ctt gag tgg atg 144 Ser Phe Ser Trp Leu Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga agg atc atc
cct atc att cat tct gaa acc tac gca cag aac ttt 192 Gly Arg Ile Ile
Pro Ile Ile His Ser Glu Thr Tyr Ala Gln Asn Phe 50 55 60 cag ggc
aga gtc acc atg acc gcg gac gaa tct acg agt aca gtc tat 240 Gln Gly
Arg Val Thr Met Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 65 70 75 80
gtg gag gtg aga agc ctg aga tct gaa gac acg gcc gtc tat tac tgt 288
Val Glu Val Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga gac tcc ccc ccc tac aat gca gac ttt gat ttc tgg ggc
aga 336 Ala Arg Asp Ser Pro Pro Tyr Asn Ala Asp Phe Asp Phe Trp Gly
Arg 100 105 110 ggc acc ctg gtc acc gtc tcg agt gga ggc ggc ggt tca
ggc gga ggt 384 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca cag tct gtg
ctg act cag cca ccc 432 Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val
Leu Thr Gln Pro Pro 130 135 140 tca gtg tcc gtg tct cca gga cag aca
gcc acc atc acc tgc tct gga 480 Ser Val Ser Val Ser Pro Gly Gln Thr
Ala Thr Ile Thr Cys Ser Gly 145 150 155 160 gac aaa ttg ggg gat aaa
tat gct tcc tgg tat cag aag aag gca gga 528 Asp Lys Leu Gly Asp Lys
Tyr Ala Ser Trp Tyr Gln Lys Lys Ala Gly 165 170 175 cag tcc cct gtg
ctg gtc atc tat caa gat aac aag cgg ccg tca ggg 576 Gln Ser Pro Val
Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly 180 185 190 atc cct
gag cga ttc tct ggc tcc aac tct ggg aac aca gcc act ctg 624 Ile Pro
Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu 195 200 205
acc atc agc ggg acc cag gct atg gat gag gct gac tat tac tgt cag 672
Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln 210
215 220 gcg tgg gac agc agt gtg gtt ttc ggc gga ggg acc aag gtc acg
gtc 720 Ala Trp Asp Ser Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr
Val 225 230 235 240 cta ggt 726 Leu Gly <210> SEQ ID NO
91
<211> LENGTH: 738 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(738) <223> OTHER INFORMATION:
Polynucleotide encoding RGC0107 scFv protein <400> SEQUENCE:
91 cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag ccg tcg gag
48 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15 act ctg tcc ctc acc tgc acc gtc tcc ggt gac tca ctt agt
agg agt 96 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Leu Ser
Arg Ser 20 25 30 agt tac tac tgg ggc tgg atc cgc cag ccc cca ggg
aag ggg ctg gag 144 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly
Lys Gly Leu Glu 35 40 45 tgg att gga agt gtc ttt tat agt ggg agc
gcc gac tac aac ccg tcc 192 Trp Ile Gly Ser Val Phe Tyr Ser Gly Ser
Ala Asp Tyr Asn Pro Ser 50 55 60 ctc aag agt cgc gcc tcc ata tca
gtg gac acg tac caa aac caa gtc 240 Leu Lys Ser Arg Ala Ser Ile Ser
Val Asp Thr Tyr Gln Asn Gln Val 65 70 75 80 tcc ctg aag ttg acc tct
gtg acc gcc gcg gac acg gcc gtg tat tac 288 Ser Leu Lys Leu Thr Ser
Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 tgt gcg agg gat
gac ggg agc acc ttc gac ccc tgg ggc cga gga acc 336 Cys Ala Arg Asp
Asp Gly Ser Thr Phe Asp Pro Trp Gly Arg Gly Thr 100 105 110 ctg gtc
acc gtc tcg agt gga ggc ggc ggt tca ggc gga ggt ggc tct 384 Leu Val
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125
ggc ggt ggc gga agt gca ctt tcc tat gtg ctg act cag cca ccc tca 432
Gly Gly Gly Gly Ser Ala Leu Ser Tyr Val Leu Thr Gln Pro Pro Ser 130
135 140 gcg tct gag acc ccc ggg cag agg gtc acc atc tct tgt tct gga
agc 480 Ala Ser Glu Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly
Ser 145 150 155 160 agc gcc aac atc gaa tat aat ttt gta tac tgg tac
cag caa ctc cca 528 Ser Ala Asn Ile Glu Tyr Asn Phe Val Tyr Trp Tyr
Gln Gln Leu Pro 165 170 175 gga acg gcc ccc aaa ctc ctc atc tat agg
aat aat cag cgg ccc tca 576 Gly Thr Ala Pro Lys Leu Leu Ile Tyr Arg
Asn Asn Gln Arg Pro Ser 180 185 190 ggg gtc cct gat cga ttc tct ggc
tcc aag tct ggc acc tca gcc tcc 624 Gly Val Pro Asp Arg Phe Ser Gly
Ser Lys Ser Gly Thr Ser Ala Ser 195 200 205 ctg gcc atc agt ggg ctc
cgg tcc gag gat gag gcc gat tat tac tgt 672 Leu Ala Ile Ser Gly Leu
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 210 215 220 gca gca tgg gat
gac agt ctg aat ggt tat gtc ttc gga act ggg acc 720 Ala Ala Trp Asp
Asp Ser Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr 225 230 235 240 aag
gtc acc gtc cta ggt 738 Lys Val Thr Val Leu Gly 245 <210> SEQ
ID NO 92 <211> LENGTH: 738 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(738) <223> OTHER
INFORMATION: Polynucleotide encoding RGC0108 scFv protein
<400> SEQUENCE: 92 cag gtg cag ctg cag gag tcg ggc cca gga
ctg gtg aag ccg tcg gag 48 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
Leu Val Lys Pro Ser Glu 1 5 10 15 acc ctg tcc ctc acc tgc act gtc
tct ggg gac tcc atc gac aag agt 96 Thr Leu Ser Leu Thr Cys Thr Val
Ser Gly Asp Ser Ile Asp Lys Ser 20 25 30 tct tac tac tgg gcc tgg
atc cgt cag ccc cca ggg aag ggc ctg gag 144 Ser Tyr Tyr Trp Ala Trp
Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 tgg att gcg agt
gtc ttt tac gat ggg acc gcc gac tac agt ccg tcc 192 Trp Ile Ala Ser
Val Phe Tyr Asp Gly Thr Ala Asp Tyr Ser Pro Ser 50 55 60 ctc agg
agt cga gtc tcc atg tcg gta gac agg tcc cta aac cac gtc 240 Leu Arg
Ser Arg Val Ser Met Ser Val Asp Arg Ser Leu Asn His Val 65 70 75 80
tcc ctg agg ctg acc tct ctg acc gcc gcg gac acg gcc act tat tac 288
Ser Leu Arg Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr 85
90 95 tgt gcg aga gat gac ggg agt tcg ttc gac ccc tgg ggc cga ggc
acc 336 Cys Ala Arg Asp Asp Gly Ser Ser Phe Asp Pro Trp Gly Arg Gly
Thr 100 105 110 ctg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc gga
ggt ggc tct 384 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser 115 120 125 ggc ggt ggc gga agt gca ctt tcc tat gtg ctg
act cag cca ccc tca 432 Gly Gly Gly Gly Ser Ala Leu Ser Tyr Val Leu
Thr Gln Pro Pro Ser 130 135 140 gcg tct ggg acc ccc ggg cag agg gtc
acc atc tct tgt tct gga agc 480 Ala Ser Gly Thr Pro Gly Gln Arg Val
Thr Ile Ser Cys Ser Gly Ser 145 150 155 160 agc tcc aac acc gga agt
aat tat gta tac tgg tac cag cag ctc cca 528 Ser Ser Asn Thr Gly Ser
Asn Tyr Val Tyr Trp Tyr Gln Gln Leu Pro 165 170 175 gga acg gcc ccc
aaa ctc ctc atc tat agg aat aat cag cgg ccc tca 576 Gly Thr Ala Pro
Lys Leu Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser 180 185 190 ggg gtc
cct gac cga ttc tct ggc tcc aag tct ggc acc tca gcc tcc 624 Gly Val
Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 195 200 205
ctg gcc atc agt ggg ctc cgg tcc gag gat gag gct gat tat tac tgt 672
Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 210
215 220 gca gca tgg gat gac agc ctg agt ggt tat gtc ttc gga act ggg
acc 720 Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val Phe Gly Thr Gly
Thr 225 230 235 240 aag gtc acc gtc cta ggt 738 Lys Val Thr Val Leu
Gly 245 <210> SEQ ID NO 93 <211> LENGTH: 738
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(738) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0110 scFv protein <400> SEQUENCE: 93 cag gtc cag
ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc 48 Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 tca
gtg aag att tcc tgc aag gca tct gga tac acc ttc aac aga tat 96 Ser
Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Arg Tyr 20 25
30 tac atc cac tgg gtg cga cag gcc cct gga caa gga ctt gag tgg gtg
144 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val
35 40 45 gga att atc aac cct cgt gga gat agc gca aat tac gca cag
aag ttc 192 Gly Ile Ile Asn Pro Arg Gly Asp Ser Ala Asn Tyr Ala Gln
Lys Phe 50 55 60 cag ggc aga gtc acc ctg acc agg gac acg tcc gcg
cgc aca gtt tac 240 Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala
Arg Thr Val Tyr 65 70 75 80 atg gaa atg aac agc ctg aga cct gac gac
acg gcc gta tat tat tgt 288 Met Glu Met Asn Ser Leu Arg Pro Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gag ggg gtg gga gct act
tgg gtc cac tgg ggc aaa gga acc 336 Ala Arg Glu Gly Val Gly Ala Thr
Trp Val His Trp Gly Lys Gly Thr 100 105 110 ctg gtc acc gtc tcg agt
gga ggc ggc ggt tca ggc gga ggt ggc tct 384 Leu Val Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 ggc ggt ggc gga
agt gca ctt aat ttt atg ctg act cag ccc cac tct 432 Gly Gly Gly Gly
Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His Ser 130 135 140 gtg tcg
ggg tct ccg ggg aag acg gta acc atc tcc tgc acc ggc agc 480 Val Ser
Gly Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly Ser 145 150 155
160 agt ggc agc att gcc agc aac tat gtg cag tgg tac cag cag cgc ccg
528 Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro
165 170 175 ggc agt gcc ccc acc act gtg atc tat gag gat aac caa aga
ccc tct 576 Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg
Pro Ser 180 185 190 ggg gtc cct gat cgg ttc tct ggc tcc atc gac cgc
tcc tcc aac tct 624 Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg
Ser Ser Asn Ser 195 200 205 gcc tcc ctc acc atc tct gga ctg aag act
gag gac gag gct gac tac 672 Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr
Glu Asp Glu Ala Asp Tyr 210 215 220 tac tgt cag tct tct gat acc atg
ttc cag gtg ttc ggc gga ggg acc 720 Tyr Cys Gln Ser Ser Asp Thr Met
Phe Gln Val Phe Gly Gly Gly Thr 225 230 235 240 aag ctg acc gtc cta
ggt 738 Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 94
<211> LENGTH: 738 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(738) <223> OTHER INFORMATION:
Polynucleotide encoding RGC0114 scFv protein <400> SEQUENCE:
94 cag atg cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg tcc
48 Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15 tcg gtg aag gtc tcc tgc aag gct tct gga gga acc ttc agc
agc tct 96 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser
Ser Ser 20 25 30 tca atc aat tgg gtg cga cag gcc cct gga caa gga
ctt gag tgg atg 144
Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35
40 45 gga gtg atc atc tct aat ctt ggt aca cca tat tat gca cag agt
ttc 192 Gly Val Ile Ile Ser Asn Leu Gly Thr Pro Tyr Tyr Ala Gln Ser
Phe 50 55 60 cag ggc aga gtc acg ata tcc gcg gac aaa tct acg ggg
act gtc tac 240 Gln Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Gly
Thr Val Tyr 65 70 75 80 ctg gac gtg agt agc ctg aga tct gac gac tcg
gcc acg tat tac tgt 288 Leu Asp Val Ser Ser Leu Arg Ser Asp Asp Ser
Ala Thr Tyr Tyr Cys 85 90 95 gcg aga gct cgc cgg ctg tgg cag act
ttt gac atc tgg ggc aag gga 336 Ala Arg Ala Arg Arg Leu Trp Gln Thr
Phe Asp Ile Trp Gly Lys Gly 100 105 110 acc ctg gtc acc gtc tcg agt
gga ggc ggc ggt tca ggc gga ggt ggc 384 Thr Leu Val Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc gga
agt gca cag tct gtg ctg acg cag ccg ccc tca 432 Ser Gly Gly Gly Gly
Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser 130 135 140 gcg tct ggg
gcc ccc ggg cag agg gtc gtc atc tca tgt tct gga agc 480 Ala Ser Gly
Ala Pro Gly Gln Arg Val Val Ile Ser Cys Ser Gly Ser 145 150 155 160
acg tcc agc att gga agt aat act gtg aac tgg tac aaa cac gtc cca 528
Thr Ser Ser Ile Gly Ser Asn Thr Val Asn Trp Tyr Lys His Val Pro 165
170 175 gga gag gcc ccc aaa ctc ctc atc tac agt tcc act cag cgg ccc
tca 576 Gly Glu Ala Pro Lys Leu Leu Ile Tyr Ser Ser Thr Gln Arg Pro
Ser 180 185 190 ggg gtc cct ggc cgc ttc tct ggc tcc acg tct ggc acc
tca ggc tcc 624 Gly Val Pro Gly Arg Phe Ser Gly Ser Thr Ser Gly Thr
Ser Gly Ser 195 200 205 ctg acc atc agt ggg ctc cag tct ggg gat gag
gct gat tac tac tgt 672 Leu Thr Ile Ser Gly Leu Gln Ser Gly Asp Glu
Ala Asp Tyr Tyr Cys 210 215 220 gca gca ttt gat gac agc ctg aat ggt
ttt gtc ttc gga act ggg acc 720 Ala Ala Phe Asp Asp Ser Leu Asn Gly
Phe Val Phe Gly Thr Gly Thr 225 230 235 240 aag ctg acc gtc cta ggt
738 Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 95
<211> LENGTH: 726 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(726) <223> OTHER INFORMATION:
Polynucleotide encoding RGC0115 scFv protein <400> SEQUENCE:
95 cag gtc acc ttg aag gag tct ggg gga ggt gtg gta cgg cct ggg ggg
48 Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly
1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt gat
gat tat 96 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp
Asp Tyr 20 25 30 ggc atg agc tgg gtc cgc caa gct cca ggg aag ggg
ctg gag tgg gtc 144 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 tct ggt att aat tgg aat ggt ggt agc aca
ggt tat gca gac tct gtg 192 Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr
Gly Tyr Ala Asp Ser Val 50 55 60 aag ggc cga ttc acc atc tcc aga
gac aac gcc aag aac tcc ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 ctg caa atg aac agt ctg
aga gcc gag gac aca gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gca aga agg cgg
tat gcg ttg gat tat tgg ggc aag gga acc ctg gtc 336 Ala Arg Arg Arg
Tyr Ala Leu Asp Tyr Trp Gly Lys Gly Thr Leu Val 100 105 110 acc gtc
tcg agt gga ggc ggc ggt tca ggc gga ggt ggc tct ggc ggt 384 Thr Val
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125
ggc gga agt gca ctt tct tct gag ctg act cag gac cct gct gtg tct 432
Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser 130
135 140 gtg gcc ttg gga cag aca gtc agg atc aca tgc caa gga gac agc
ctc 480 Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser
Leu 145 150 155 160 aga aac tat tat gca agc tgg tac cag cag aag cca
gga cag gcc cct 528 Arg Asn Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 165 170 175 gta ctt gtc atc tat ggt aaa aac aat cgg
ccc tca ggg atc cca gtc 576 Val Leu Val Ile Tyr Gly Lys Asn Asn Arg
Pro Ser Gly Ile Pro Val 180 185 190 cga ttc tct ggc tcc agc tca gga
aac aca gct tcc ttg acc atc act 624 Arg Phe Ser Gly Ser Ser Ser Gly
Asn Thr Ala Ser Leu Thr Ile Thr 195 200 205 ggg act cag gcg gaa gat
gga gct gac tat tac tgt aac tcc cgg gac 672 Gly Thr Gln Ala Glu Asp
Gly Ala Asp Tyr Tyr Cys Asn Ser Arg Asp 210 215 220 agc agt ggt aag
cat gtg ata ttc ggc gga ggg acc aag gtc acc gtc 720 Ser Ser Gly Lys
His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val 225 230 235 240 cta
ggt 726 Leu Gly <210> SEQ ID NO 96 <211> LENGTH: 756
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(756) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0128 scFv protein <400> SEQUENCE: 96 gag gtg cag
ctg gtg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctc aga ctc tcc tgt gaa gcc tct gga ttc agc ttt agt agt tat 96 Ser
Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Ser Phe Ser Ser Tyr 20 25
30 ggc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tct agt atc act agt cgt ggt cgt ggt gga agt aca tac cac
gca gat 192 Ser Ser Ile Thr Ser Arg Gly Arg Gly Gly Ser Thr Tyr His
Ala Asp 50 55 60 tac gtg gag ggc cgg ttc acc atc tcc aga gac gat
gcc aag aac acg 240 Tyr Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp
Ala Lys Asn Thr 65 70 75 80 ctg tat ctg caa atg aac agc ctg cga gcc
gag gac acg gcc gta tat 288 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
Glu Asp Thr Ala Val Tyr 85 90 95 tat tgt gca aaa gat tgg agt gcc
tac gat agc gtc cac ctc ttt gac 336 Tyr Cys Ala Lys Asp Trp Ser Ala
Tyr Asp Ser Val His Leu Phe Asp 100 105 110 tac tgg ggc cga gga acc
ctg gtc acc gtc tcg agt gga ggc ggc ggt 384 Tyr Trp Gly Arg Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125 tca ggc gga ggt
ggc tct ggc ggt ggc gga agt gca ctt aat ttt atg 432 Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met 130 135 140 ctg act
cag ccc cac tct gtg tcg gag tct ccg ggg aag acg gta acc 480 Leu Thr
Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr 145 150 155
160 atc tcc tgc acc cgc aac act gac aac att gcc ttc aac tat gtg cag
528 Ile Ser Cys Thr Arg Asn Thr Asp Asn Ile Ala Phe Asn Tyr Val Gln
165 170 175 tgg ttc cag cag cgc ccg ggc agt tcc ccc acc act gtg atc
tat gag 576 Trp Phe Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile
Tyr Glu 180 185 190 gat aac caa aga ccc tct ggg gtc cct gat cgg ttc
tct ggc tcc atc 624 Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe
Ser Gly Ser Ile 195 200 205 gac agc tcc tcc aac tct gcc tcc ctc acc
atc tct gga ctg aag act 672 Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr
Ile Ser Gly Leu Lys Thr 210 215 220 gag gac gag gct gac tac tac tgt
cag tct tat gat ggc aac aat ctg 720 Glu Asp Glu Ala Asp Tyr Tyr Cys
Gln Ser Tyr Asp Gly Asn Asn Leu 225 230 235 240 gtg ttc ggc gga ggg
acc aag ctg acc gtc cta ggt 756 Val Phe Gly Gly Gly Thr Lys Leu Thr
Val Leu Gly 245 250 <210> SEQ ID NO 97 <211> LENGTH:
747 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(747) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0130 scFv protein <400> SEQUENCE: 97 gaa gtg cag
ctg gtg cag tct gga gct gag gtg aag aag cct ggg gcc 48 Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 tca
gtg aag gtc tcc tgc aag gct tct ggt tac acc ttt acc agc tat 96 Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25
30 ggt atc agc tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg
144 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45 gga tgg atc agc gct tac aat ggt aac aca aac tat gca cag
aag ctc 192 Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln
Lys Leu 50 55 60 cag ggc aga gtc acc atg acc aca gac aca tcc acg
agc aca gcc tac 240 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr
Ser Thr Ala Tyr 65 70 75 80 atg gag ctg agg agc ctg aga tct gac gac
acg gcc gtg tat tac tgt 288 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gat gcc cga cct cgg ggt
ata gca gct cgt cca tta ctt agc 336 Ala Arg Asp Ala Arg Pro Arg Gly
Ile Ala Ala Arg Pro Leu Leu Ser 100 105 110 tac tgg ggg agg ggg acc
acg gtc acc gtc tct tca ggt gga ggc ggt 384 Tyr Trp Gly Arg Gly Thr
Thr Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125
tca ggc gga ggt ggc agc ggc ggt ggc gga tcg cag tct gtg ttg acg 432
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr 130
135 140 cag ccg ccc tca gtg tct gcg gcc cca gga gag aag gtc acc att
tcc 480 Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Glu Lys Val Thr Ile
Ser 145 150 155 160 tgc tct gga agc acc tcc aac att ggg aat aat tat
gtc tcc tgg tac 528 Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr
Val Ser Trp Tyr 165 170 175 caa cag cac cca ggc aaa gcc ccc aaa ctc
atg att tat gat gtc agt 576 Gln Gln His Pro Gly Lys Ala Pro Lys Leu
Met Ile Tyr Asp Val Ser 180 185 190 aag cgg ccc tca ggg gtc cct gac
cga ttc tct ggc tcc aag tct ggc 624 Lys Arg Pro Ser Gly Val Pro Asp
Arg Phe Ser Gly Ser Lys Ser Gly 195 200 205 aac acg gcg tcc ctg acc
atc tct ggg gtc cag gct gag gac gag gct 672 Asn Thr Ala Ser Leu Thr
Ile Ser Gly Val Gln Ala Glu Asp Glu Ala 210 215 220 gat tat tac tgc
agc tca tat aca agc gcc agc act gtg ata ttc ggc 720 Asp Tyr Tyr Cys
Ser Ser Tyr Thr Ser Ala Ser Thr Val Ile Phe Gly 225 230 235 240 gga
ggg acc aag ctg acc gtc cta ggt 747 Gly Gly Thr Lys Leu Thr Val Leu
Gly 245 <210> SEQ ID NO 98 <211> LENGTH: 771
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(771) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0131 scFv protein <400> SEQUENCE: 98 cag gtg cag
ctg gtg cag tct ggg gct gaa gtg agg aag cct ggg gcc 48 Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 1 5 10 15 tca
gtg agg gtc tcc tgc agg gct tct gga tac agc ttc acg aat tat 96 Ser
Val Arg Val Ser Cys Arg Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25
30 gat atc aac tgg gtg cga cag gcc cct ggg caa ggg ctt gag tgg atg
144 Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45 ggc tgg atg aac cct aac ggc ggt cac aca ggc tct gca cag
aag ttc 192 Gly Trp Met Asn Pro Asn Gly Gly His Thr Gly Ser Ala Gln
Lys Phe 50 55 60 cag ggc aga gtc acc atg acc agg gac acc tcc ata
aac act gcc tac 240 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
Asn Thr Ala Tyr 65 70 75 80 atg gag ctg agc agc ctg aca tct gac gac
acg gcc gtc tat tac tgt 288 Met Glu Leu Ser Ser Leu Thr Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga ggg tct cag tgg tgt act
ggt ggt aac tgc tac gga aca cac 336 Ala Arg Gly Ser Gln Trp Cys Thr
Gly Gly Asn Cys Tyr Gly Thr His 100 105 110 tac tac tac atg gag gac
tgg ggc cga gga acc ctg gtc acc gtc tcg 384 Tyr Tyr Tyr Met Glu Asp
Trp Gly Arg Gly Thr Leu Val Thr Val Ser 115 120 125 agt gga ggc ggc
ggt tca ggc gga ggt ggc tct ggc ggt ggc gga agt 432 Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 130 135 140 gca ctt
aat ttt atg ctg act cag ccc cac tct gtg tcg gag tct ccg 480 Ala Leu
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro 145 150 155
160 ggg aag acg gta acc atc tcc tgc acc cgc aac act gac aac att gcc
528 Gly Lys Thr Val Thr Ile Ser Cys Thr Arg Asn Thr Asp Asn Ile Ala
165 170 175 ttc aac tat gtg cag tgg ttc cag cag cgc ccg ggc agt tcc
ccc acc 576 Phe Asn Tyr Val Gln Trp Phe Gln Gln Arg Pro Gly Ser Ser
Pro Thr 180 185 190 act gtg atc tat gag gat aac caa aga ccc tct ggg
gtc cct gat cgg 624 Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly
Val Pro Asp Arg 195 200 205 ttc tct ggc tcc atc gac agc tcc tcc aac
tct gcc tcc ctc acc atc 672 Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn
Ser Ala Ser Leu Thr Ile 210 215 220 tct gga ctg aag act gag gac gag
gct gac tac tac tgt cag tct tat 720 Ser Gly Leu Lys Thr Glu Asp Glu
Ala Asp Tyr Tyr Cys Gln Ser Tyr 225 230 235 240 gat ggc aac aat ctg
gtg ttc ggc gga ggg acc aag ctg acc gtc cta 768 Asp Gly Asn Asn Leu
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 245 250 255 ggt 771 Gly
<210> SEQ ID NO 99 <211> LENGTH: 732 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(732)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0137 scFv
protein <400> SEQUENCE: 99 gag gtg cag ctg gtg cag tct ggg
tct gag gtg aag aag cct ggg tcg 48 Glu Val Gln Leu Val Gln Ser Gly
Ser Glu Val Lys Lys Pro Gly Ser 1 5 10 15 tca gtg aga gtc tcc tgc
aag act tct gga gac acc ttc agg agg ttt 96 Ser Val Arg Val Ser Cys
Lys Thr Ser Gly Asp Thr Phe Arg Arg Phe 20 25 30 act gtc agt tgg
gtg cga cag gcc cct gga cag ggg ctt gag tgg atg 144 Thr Val Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga agg
gtc atc cct ctc tac aat tct cca acc tac gcc cag aag ttc 192 Gly Arg
Val Ile Pro Leu Tyr Asn Ser Pro Thr Tyr Ala Gln Lys Phe 50 55 60
cag gac aga gtc acg att acc gcg gac gaa tcc acg acc aca gtc tac 240
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Val Tyr 65
70 75 80 atg gag gtg acc ggc ctg aca tct gaa gac acc gcc gtc tat
tac tgt 288 Met Glu Val Thr Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga gac tcc ccc ccc tac aat gca gac ttt gat
tca tgg ggc caa 336 Ala Arg Asp Ser Pro Pro Tyr Asn Ala Asp Phe Asp
Ser Trp Gly Gln 100 105 110 ggg aca atg gtc acc gtc tcg agt gga ggc
ggc ggt tca ggc gga ggt 384 Gly Thr Met Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca
cag gct gtg ctg act cag ccg tcg 432 Gly Ser Gly Gly Gly Gly Ser Ala
Gln Ala Val Leu Thr Gln Pro Ser 130 135 140 tca atg tct gtg tcc ccg
gga cag acg gcc atc atc acc tgc tct gga 480 Ser Met Ser Val Ser Pro
Gly Gln Thr Ala Ile Ile Thr Cys Ser Gly 145 150 155 160 aat aga ttg
ggg gac aaa tat gtt tcg tgg tat cag cag agg cca ggc 528 Asn Arg Leu
Gly Asp Lys Tyr Val Ser Trp Tyr Gln Gln Arg Pro Gly 165 170 175 cag
tcc cct gtc ctg gtc ata ttt caa gat aac aag agg ccc tca gga 576 Gln
Ser Pro Val Leu Val Ile Phe Gln Asp Asn Lys Arg Pro Ser Gly 180 185
190 att tct gag cga ttc tct ggc tcc aac tct ggc aac aca gcc act ctg
624 Ile Ser Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu
195 200 205 acc atc agc gac gtc gag gcc atg gat gag gct gaa tat ttc
tgt cag 672 Thr Ile Ser Asp Val Glu Ala Met Asp Glu Ala Glu Tyr Phe
Cys Gln 210 215 220 gcg tgg cac agt agt ttt tat tat gcc ttc gga act
ggg acc aag ctg 720 Ala Trp His Ser Ser Phe Tyr Tyr Ala Phe Gly Thr
Gly Thr Lys Leu 225 230 235 240 acc gtc cta ggt 732 Thr Val Leu Gly
<210> SEQ ID NO 100 <211> LENGTH: 744 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(744)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0139 scFv
protein <400> SEQUENCE: 100 gag gtg cag ctg gtg cag tct ggg
gct gaa gtg aag gag ccg ggg gcc 48 Glu Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Glu Pro Gly Ala 1 5 10 15 tca atg aag gtt tac tgc
aag gca tct gga tac agg ttc acc agg tat 96 Ser Met Lys Val Tyr Cys
Lys Ala Ser Gly Tyr Arg Phe Thr Arg Tyr 20 25 30 tat ata cat tgg
gta cga cag gcc cct gga caa ggg ctt gag tgg atg 144 Tyr Ile His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga aca
atc aac cct agt gat ggt agc aca agt tac gca cag aag ttc 192 Gly Thr
Ile Asn Pro Ser Asp Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60
cag gac aga gtc act atg acc agg gac acg tcc acg aga aca gtc tac 240
Gln Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Arg Thr Val Tyr 65
70 75 80 atg gag ttg agc agc ctg aga tct gag gac acg gcc atg tat
tac tgt 288 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr
Tyr Cys 85 90 95 ggg aga gtg gag gac tat tac tct gaa agt aat ggt
cca gct gat aac 336 Gly Arg Val Glu Asp Tyr Tyr Ser Glu Ser Asn Gly
Pro Ala Asp Asn 100 105 110 tgg ggc cgg ggg aca atg gtc acc gtc tcg
agt gga ggc ggc ggt tca 384 Trp Gly Arg Gly Thr Met Val Thr Val Ser
Ser Gly Gly Gly Gly Ser 115 120 125 ggc gga ggt ggc tct ggc ggt ggc
gga agt gca cag tct gtg ctg acg 432 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Ala Gln Ser Val Leu Thr 130 135 140 cag ccg ccc tcg gtg tca
gtg gcc cca gga cag acg gcc agc att acc 480 Gln Pro Pro Ser Val Ser
Val Ala Pro Gly Gln Thr Ala Ser Ile Thr 145 150 155 160 tgt ggg gga
aac aag att ggg act aaa ggt gtg cac tgg tac cag cag 528 Cys Gly Gly
Asn Lys Ile Gly Thr Lys Gly Val His Trp Tyr Gln Gln 165 170 175 aag
cca ggc cgg gcc cct gtg ctg gtc gtc tat gat gat ggc gac cgg 576 Lys
Pro Gly Arg Ala Pro Val Leu Val Val Tyr Asp Asp Gly Asp Arg 180 185
190 ccc tca ggg atc cct gac cga ttc tct ggc tcc aac tct gac aac acg
624 Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Asn Ser Asp Asn
Thr
195 200 205 gcc acc ctg acc atc agc agg gtc gaa gcc ggg gat gag gcc
gac tat 672 Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala
Asp Tyr 210 215 220 tac tgt cag gtg tgg gat agt gat agt gat cta ggg
gta ttc ggc gga 720 Tyr Cys Gln Val Trp Asp Ser Asp Ser Asp Leu Gly
Val Phe Gly Gly 225 230 235 240 ggg acc aag gtc acc gtc cta ggt 744
Gly Thr Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO 101
<211> LENGTH: 729 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(729) <223> OTHER INFORMATION:
Polynucleotide encoding RGC0142 scFv protein <400> SEQUENCE:
101 gaa gtg cag ctg gtg cag tct ggg gct gcg gtg aag aag cct ggg tcg
48 Glu Val Gln Leu Val Gln Ser Gly Ala Ala Val Lys Lys Pro Gly Ser
1 5 10 15 tcg gtg aag att tcg tgc gag gtt tct ggg ggc atc ttc aag
aac tat 96 Ser Val Lys Ile Ser Cys Glu Val Ser Gly Gly Ile Phe Lys
Asn Tyr 20 25 30 gct atc agc tgg gtg cga cag gcc cct gga caa gga
ctt gag tgg atg 144 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Met 35 40 45 gga gga agc atc cct atg tat ggg aca cca
agt tac gct ccg aag ttc 192 Gly Gly Ser Ile Pro Met Tyr Gly Thr Pro
Ser Tyr Ala Pro Lys Phe 50 55 60 cag ggc aga gtc act att atc gcg
gac gaa tct acg agc aca gcc tac 240 Gln Gly Arg Val Thr Ile Ile Ala
Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 atg gag ctg agc agc ctg
aga tct gag gac acg gcc atg tac tac tgt 288 Met Glu Leu Ser Ser Leu
Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 gcg cgg gag aca
act gaa gtc gat gac gct ttt gat atc tgg ggc aga 336 Ala Arg Glu Thr
Thr Glu Val Asp Asp Ala Phe Asp Ile Trp Gly Arg 100 105 110 ggg aca
atg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc gga ggt 384 Gly Thr
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125
ggc tct ggc ggt ggc gga agt gca cag tct gtg ttg acg cag ccg ccc 432
Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro 130
135 140 tcg gtg tct gca gcc ccc agg cag agg gtc acc atc tcc tgt tct
gga 480 Ser Val Ser Ala Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser
Gly 145 150 155 160 agc agt tcc aac atc gga aat aat gtt gtg aac tgg
tac cag cac ttc 528 Ser Ser Ser Asn Ile Gly Asn Asn Val Val Asn Trp
Tyr Gln His Phe 165 170 175 ccg gga aag gct ccc agg ctc ctc atc ttc
tct gat agt ctc ctg tcc 576 Pro Gly Lys Ala Pro Arg Leu Leu Ile Phe
Ser Asp Ser Leu Leu Ser 180 185 190 gac cga ttc tct ggc tcc aag tcc
ggc acc tca gcc tcc ctg gcc atc 624 Asp Arg Phe Ser Gly Ser Lys Ser
Gly Thr Ser Ala Ser Leu Ala Ile 195 200 205 agt gga ctg cag tct gac
gat gag gct gaa tat tac tgt gcg tca tgg 672 Ser Gly Leu Gln Ser Asp
Asp Glu Ala Glu Tyr Tyr Cys Ala Ser Trp 210 215 220 gat gac agc ctg
aat ggt ttg gtt ttc ggc gga ggg acc aag ctg acc 720 Asp Asp Ser Leu
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr 225 230 235 240 gtc
cta ggt 729 Val Leu Gly <210> SEQ ID NO 102 <211>
LENGTH: 729 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(729) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0145 scFv protein <400> SEQUENCE: 102 gag gtc cag
ctg gtg cag tct ggg gct gag gtg aag aag cct ggg tcg 48 Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 tcg
gtg aag att tcc tgc gag gtt tct ggg ggc atc ttc aag aac tat 96 Ser
Val Lys Ile Ser Cys Glu Val Ser Gly Gly Ile Phe Lys Asn Tyr 20 25
30 gct atc agc tgg gtg cga cag gcc cct gga caa gga ctt gag tgg atg
144 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45 gga gga agc atc cct atg tat ggg aca cca agt tac gct ccg
aag ttc 192 Gly Gly Ser Ile Pro Met Tyr Gly Thr Pro Ser Tyr Ala Pro
Lys Phe 50 55 60 cag ggc aga gtc act att atc gcg gac gaa tct acg
agc aca gcc tac 240 Gln Gly Arg Val Thr Ile Ile Ala Asp Glu Ser Thr
Ser Thr Ala Tyr 65 70 75 80 atg gag ctg agc agc ctg aga tct gag gac
acg gcc atg tac tac tgt 288 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
Thr Ala Met Tyr Tyr Cys 85 90 95 gcg cgg gag aca act gaa gtc gat
gac gct ttt aat atc tgg ggc aga 336 Ala Arg Glu Thr Thr Glu Val Asp
Asp Ala Phe Asn Ile Trp Gly Arg 100 105 110 ggc acc ctg gtc acc gtc
tcg agt gga ggc ggc ggt tca ggc gga ggt 384 Gly Thr Leu Val Thr Val
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 ggc tct ggc ggt
ggc gga agt gca cag tct gtg ctg acg cag ccg ccc 432 Gly Ser Gly Gly
Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro 130 135 140 tcg gtg
tct gca gcc ccc agg cag agg gtc acc atc tcc tgt tct gga 480 Ser Val
Ser Ala Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly 145 150 155
160 agc agt tcc aac atc gga aat aat gtt gtg aac tgg tac cag cac ttc
528 Ser Ser Ser Asn Ile Gly Asn Asn Val Val Asn Trp Tyr Gln His Phe
165 170 175 ccg gga aag gct ccc agg ctc ctc atc ttt cct gat agt ctc
ctg tcc 576 Pro Gly Lys Ala Pro Arg Leu Leu Ile Phe Pro Asp Ser Leu
Leu Ser 180 185 190 gac cga ttc tct ggc tcc aag tcc ggc acc tca gcc
tcc ctg gcc atc 624 Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala
Ser Leu Ala Ile 195 200 205 agt ggg ctg cag tct gac gat gag gct gaa
tat tac tgt gcg tca tgg 672 Ser Gly Leu Gln Ser Asp Asp Glu Ala Glu
Tyr Tyr Cys Ala Ser Trp 210 215 220 gat gac agc ctg aat ggt ttg gtt
ttc ggc gga ggg acc aag ctg acc 720 Asp Asp Ser Leu Asn Gly Leu Val
Phe Gly Gly Gly Thr Lys Leu Thr 225 230 235 240 gtc cta ggt 729 Val
Leu Gly <210> SEQ ID NO 103 <211> LENGTH: 747
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(747) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0150 scFv protein <400> SEQUENCE: 103 cag gtg cag
ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg 48 Gln Val Gln
Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 1 5 10 15 acc
ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt 96 Thr
Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 20 25
30 aac tac tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg
144 Asn Tyr Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45 att ggg gag atc tat cat gat ggg agc acc aac tac aac ccg
tcc ctc 192 Ile Gly Glu Ile Tyr His Asp Gly Ser Thr Asn Tyr Asn Pro
Ser Leu 50 55 60 aag agt cga gtc acc atg tca gca gac aag tcc aag
aac cag ttc tcc 240 Lys Ser Arg Val Thr Met Ser Ala Asp Lys Ser Lys
Asn Gln Phe Ser 65 70 75 80 ctg aag ctg agc tct gtg acc gcc gcg gac
acg gcc gtg tat tac tgt 288 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gat tcc ccc tcg tat agc
agt ggc tgg tac tct gac tac tgg 336 Ala Arg Asp Ser Pro Ser Tyr Ser
Ser Gly Trp Tyr Ser Asp Tyr Trp 100 105 110 ggc caa ggc acc ctg gtc
acc gtc tcg agt gga ggc ggc ggt tca ggc 384 Gly Gln Gly Thr Leu Val
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125 gga ggt ggc tct
ggc ggt ggc gga agt gca cag tct gtg ttg acg cag 432 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln 130 135 140 ccg ccc
tca gcg tct ggg acc ccc ggg cgg agg gtc acc atc tct tgt 480 Pro Pro
Ser Ala Ser Gly Thr Pro Gly Arg Arg Val Thr Ile Ser Cys 145 150 155
160 tcc ggg agc agc tcc aac atc gga agt aac cct gta aac tgg tac cag
528 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn Trp Tyr Gln
165 170 175 caa ctc cca gga acg gcc ccc aaa atc gtc atg tat agt act
gat cag 576 Gln Leu Pro Gly Thr Ala Pro Lys Ile Val Met Tyr Ser Thr
Asp Gln 180 185 190 cgg acc tca ggg gcc cct gac cga ttc tct ggc tcc
aag tct ggc acc 624 Arg Thr Ser Gly Ala Pro Asp Arg Phe Ser Gly Ser
Lys Ser Gly Thr 195 200 205 tca gcc tcc ctg gcc atc act ggg ctc cag
tct gag gat gag gct gat 672 Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln
Ser Glu Asp Glu Ala Asp 210 215 220 tat ttc tgt gca aca tgg gat gac
agc ccg aat gcc gtg gta ttc ggc 720 Tyr Phe Cys Ala Thr Trp Asp Asp
Ser Pro Asn Ala Val Val Phe Gly 225 230 235 240 gga ggg acc aag ctg
acc gtc cta ggt 747 Gly Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 104 <211> LENGTH: 753 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(753)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0153 scFv
protein
<400> SEQUENCE: 104 gaa gtg cag ctg gtg cag tct ggg gct gag
gtg aag aag cct ggg gcc 48 Glu Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 tca gtg aag gtc tcc tgc aag gct
tct ggc tac acc ttc acc ggc gac 96 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Gly Asp 20 25 30 tat ttg cac tgg gtg cga
cag gcc cct gga caa ggg ctt gag tgg atg 144 Tyr Leu His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga tgg atc aac
cct aac act ggt ggc aca aac tat gca cag aag ttt 192 Gly Trp Ile Asn
Pro Asn Thr Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60 cag ggc
agg gtc acc atg acc agg gac acg tcc atc agc aca gcg tac 240 Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80
atg gag ttg agc agg ctg aga tct gac gac acg gcc atc tat tac tgt 288
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 85
90 95 gcg aga gcg cga tat tac tat gac agt act agt tac ccc ttt gac
tac 336 Ala Arg Ala Arg Tyr Tyr Tyr Asp Ser Thr Ser Tyr Pro Phe Asp
Tyr 100 105 110 tgg ggc cgg gga acc ctg gtc acc gtc tcg agt gga ggc
ggc ggt tca 384 Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser 115 120 125 ggc gga ggt ggc tct ggc ggt ggc gga agt gca
ctt aat ttt atg ctg 432 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
Leu Asn Phe Met Leu 130 135 140 act cag ccc cac tct gtg tcg gag tct
ccg ggt aag aca gta act ctc 480 Thr Gln Pro His Ser Val Ser Glu Ser
Pro Gly Lys Thr Val Thr Leu 145 150 155 160 tcc tgc acc cgc tcc agt
ggc agc att tca ttc gac tat gtg cag tgg 528 Ser Cys Thr Arg Ser Ser
Gly Ser Ile Ser Phe Asp Tyr Val Gln Trp 165 170 175 tat caa cag cgg
ccg ggc agc tcc ccc att ctt gtg atc ttt gaa gat 576 Tyr Gln Gln Arg
Pro Gly Ser Ser Pro Ile Leu Val Ile Phe Glu Asp 180 185 190 gac caa
aga ccc tct ggg gtc cct gat cga ttc tct ggc tcc atc gac 624 Asp Gln
Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp 195 200 205
agt acc tcc aac tct gcc tcc ctc acc atc tct ggc ctg cag agt gag 672
Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu 210
215 220 gac gag ggt gac tac tat tgt cag act tat gat gac aac cgt cag
gtg 720 Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp Asp Asn Arg Gln
Val 225 230 235 240 ttc ggc ggg ggg acc aag gtc acc gtc cta ggt 753
Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 245 250 <210> SEQ
ID NO 105 <211> LENGTH: 735 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(735) <223> OTHER
INFORMATION: Polynucleotide encoding RGC0154 scFv protein
<400> SEQUENCE: 105 cag gtc cag ctg gtg cag tct ggg gct gag
gtg agg aag cct ggg tcc 48 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Arg Lys Pro Gly Ser 1 5 10 15 tca gtg aag gtc tcc tgc acg acc
tct gaa aac acc ttt agg agg tct 96 Ser Val Lys Val Ser Cys Thr Thr
Ser Glu Asn Thr Phe Arg Arg Ser 20 25 30 agt ttc agt tgg cta cgc
cag gcc cct gga caa ggt ctt gag tgg atg 144 Ser Phe Ser Trp Leu Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga agg atc atc
cct atc att cat tct gaa acc tac gca cag aac ttt 192 Gly Arg Ile Ile
Pro Ile Ile His Ser Glu Thr Tyr Ala Gln Asn Phe 50 55 60 cag ggc
agg gtc acc atg acc gcg gac gaa tct acg agt aca gtc tat 240 Gln Gly
Arg Val Thr Met Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 65 70 75 80
gtg gag gtg aga agc ctg aga tct gaa gac acg gcc gtc tat tac tgt 288
Val Glu Val Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga gac tcc ccc ccc tac aat gca gac ttt gat ttc tgg ggc
caa 336 Ala Arg Asp Ser Pro Pro Tyr Asn Ala Asp Phe Asp Phe Trp Gly
Gln 100 105 110 gga acc ctg gtc acc gtc tcg agt gga ggc ggc ggt tca
ggc gga ggt 384 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca ctt tcc tat
gag ctg act cag cca 432 Gly Ser Gly Gly Gly Gly Ser Ala Leu Ser Tyr
Glu Leu Thr Gln Pro 130 135 140 ccc tca gtg tcc gtg tcc cca gga cag
aca gcc agc atc acc tgt tct 480 Pro Ser Val Ser Val Ser Pro Gly Gln
Thr Ala Ser Ile Thr Cys Ser 145 150 155 160 gga gat aac tta ggg gat
aag tat gtt agt tgg tat cag cag agg cca 528 Gly Asp Asn Leu Gly Asp
Lys Tyr Val Ser Trp Tyr Gln Gln Arg Pro 165 170 175 ggc cag tcc cct
gtt ctg gtc atc tat caa gat gtc aag cgg ccc tct 576 Gly Gln Ser Pro
Val Leu Val Ile Tyr Gln Asp Val Lys Arg Pro Ser 180 185 190 ggg att
cct gag cga ttc tct ggc tcc aac tct ggg aac aca gcc act 624 Gly Ile
Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 195 200 205
ctg acc atc agc ggg acc cag gct atg gat gag gct gac tac tac tgt 672
Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys 210
215 220 cag gcg tgg gac agt aac act tct tat gtc ttc gga act ggg acc
cag 720 Gln Ala Trp Asp Ser Asn Thr Ser Tyr Val Phe Gly Thr Gly Thr
Gln 225 230 235 240 ctc acc gtt tta agt 735 Leu Thr Val Leu Ser 245
<210> SEQ ID NO 106 <211> LENGTH: 759 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(759)
<223> OTHER INFORMATION: Polynucleotide encoding RGC0157 scFv
protein <400> SEQUENCE: 106 cag gta cag ctg cag cag tcg ggg
gct gag gtg aag aag cct ggg tcc 48 Gln Val Gln Leu Gln Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 tcg gtg aag gtc tcc tgc
aag gct tct gga ggc acc ttc aac agt tct 96 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Gly Thr Phe Asn Ser Ser 20 25 30 gct atc agt tgg
gtg cga cag gcc cct gga caa ggg ctt gag tgg atg 144 Ala Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga agg
atc atc cct atc ctt ggt ata gca aac tac gca cag aat ttc 192 Gly Arg
Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Asn Phe 50 55 60
cag gac aga gtc acg att acc gcg gac aaa tcc acg agc aca gcc tac 240
Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65
70 75 80 atg gag ctg agc agc ctg aca tct gag gac acg gcc gtt tat
tac tgt 288 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 acg aga gat tac gtg gat cca gat atg ctt acg gcc
gga tac tac ttt 336 Thr Arg Asp Tyr Val Asp Pro Asp Met Leu Thr Ala
Gly Tyr Tyr Phe 100 105 110 gac cag tgg ggc cag gga acc ctg gtc acc
gtc tcg agt gga ggc ggc 384 Asp Gln Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly 115 120 125 ggt tca ggc gga ggt ggc tct ggc
ggt ggc gga agt gca ctt aat ttt 432 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ala Leu Asn Phe 130 135 140 atg ctg act cag ccc cac
tct gtg tcg gag tct ccg ggg aag acg gta 480 Met Leu Thr Gln Pro His
Ser Val Ser Glu Ser Pro Gly Lys Thr Val 145 150 155 160 acc atc tcc
tgc acc cgc aac act gac aac att gcc ttc aac tat gtg 528 Thr Ile Ser
Cys Thr Arg Asn Thr Asp Asn Ile Ala Phe Asn Tyr Val 165 170 175 cag
tgg ttc cag cag cgc ccg ggc agt tcc ccc acc act gtg atc tat 576 Gln
Trp Phe Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr 180 185
190 gag gat aac caa aga ccc tct ggg gtc cct gat cgg ttc tct ggc tcc
624 Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser
195 200 205 atc gac agc tcc tcc aac tct gcc tcc ctc acc atc tct gga
ctg aag 672 Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
Leu Lys 210 215 220 act gag gac gag gct gac tac tac tgt cag tct tat
gat ggc aac aat 720 Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr
Asp Gly Asn Asn 225 230 235 240 ctg gtg ttc ggc gga ggg acc aag ctg
acc gtc cta ggt 759 Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
Gly 245 250 <210> SEQ ID NO 107 <211> LENGTH: 741
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(741) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0162 scFv protein <400> SEQUENCE: 107 cag gtg cag
ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc 48 Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 tca
gtg aag gtc tct tgc aag gct gct ggg ttc agg ttc agc ggc gac 96 Ser
Val Lys Val Ser Cys Lys Ala Ala Gly Phe Arg Phe Ser Gly Asp 20 25
30 tat ttg cac tgg ctg cga caa gtt cct gga caa ggg cct gag tgg atg
144 Tyr Leu His Trp Leu Arg Gln Val Pro Gly Gln Gly Pro Glu Trp Met
35 40 45 gga tgg atc aat ctc agc agt ggt ggc aca aat tat gga gag
aag ttt 192 Gly Trp Ile Asn Leu Ser Ser Gly Gly Thr Asn Tyr Gly Glu
Lys Phe 50 55 60 cag ggc cgg gtc acc atg acc agg gac agg ccc agt
agc aca gcc tac 240
Gln Gly Arg Val Thr Met Thr Arg Asp Arg Pro Ser Ser Thr Ala Tyr 65
70 75 80 atg gaa ata aaa agt ctg aga gtt gac gac acg gcc gta tat
tat tgt 288 Met Glu Ile Lys Ser Leu Arg Val Asp Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga gag agc ccc gta gta gag gcc atg gac gtc
tgg ggc cgg gga 336 Ala Arg Glu Ser Pro Val Val Glu Ala Met Asp Val
Trp Gly Arg Gly 100 105 110 acc ctg gtc acc gtc tcg agt gga ggc ggc
ggt tca ggc gga ggt ggc 384 Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc gga agt gca ctt
aat ttt atg ctg act cag ccc cac 432 Ser Gly Gly Gly Gly Ser Ala Leu
Asn Phe Met Leu Thr Gln Pro His 130 135 140 tct gtg tca gag tct ccg
ggg aag acg gta acc atc tcc tgc acc cgc 480 Ser Val Ser Glu Ser Pro
Gly Lys Thr Val Thr Ile Ser Cys Thr Arg 145 150 155 160 agc agt gac
aac att gcc ttc aat tat gtg cag tgg tac cag cag cgc 528 Ser Ser Asp
Asn Ile Ala Phe Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165 170 175 ccg
ggc agt gcc ccc acc act ttg att tat gag gat aac caa aga cct 576 Pro
Gly Ser Ala Pro Thr Thr Leu Ile Tyr Glu Asp Asn Gln Arg Pro 180 185
190 tct ggg gtc cct gat cgg ttc tct ggc tcc atc gac agc tcc tcc aac
624 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn
195 200 205 tct gcc tcc ctc acc atc tct aat ctg aag act gag gac gaa
gct gac 672 Ser Ala Ser Leu Thr Ile Ser Asn Leu Lys Thr Glu Asp Glu
Ala Asp 210 215 220 tac tac tgt cag tct tat gat ggc agt aat tat gtc
ttc gga act ggg 720 Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Asn Tyr Val
Phe Gly Thr Gly 225 230 235 240 acc aag ctg acc gtc cta ggt 741 Thr
Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 108 <211>
LENGTH: 735 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(735) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0164 scFv protein <400> SEQUENCE: 108 gag gtc cag
ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc 48 Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 tca
gtg aag gtc tcc tgc aag gcc tct gga tac acc ttc acc ggc tac 96 Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25
30 tat atg cac tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg
144 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45 gga tgg atc aat cct aaa agc ggt ggc aca aac tat cca cag
aag ttt 192 Gly Trp Ile Asn Pro Lys Ser Gly Gly Thr Asn Tyr Pro Gln
Lys Phe 50 55 60 cag ggc agg gtc acc atg acc agg gac acg tcc atc
agc aca gcc tac 240 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
Ser Thr Ala Tyr 65 70 75 80 atg gag ctg agc agg ctg aga tct gac gac
acg gcc gta tat tac tgt 288 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gag gga act ggg gac ttc
ttt gac tac tgg ggc cgg gga acc 336 Ala Arg Glu Gly Thr Gly Asp Phe
Phe Asp Tyr Trp Gly Arg Gly Thr 100 105 110 ctg gtc acc gtc tcg agt
gga ggc ggc ggt tca ggc gga ggt ggc tct 384 Leu Val Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 ggc ggt ggc gga
agt gca cag cct gtg ctg act cag ccc ccc tcc gcg 432 Gly Gly Gly Gly
Ser Ala Gln Pro Val Leu Thr Gln Pro Pro Ser Ala 130 135 140 tcc ggg
tct cct gga cag tca gtc acc atc tcc tgc act gga acc agc 480 Ser Gly
Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser 145 150 155
160 agt gac gtt ggt ggt tat aac tat gtc tcc tgg tac caa cag cac cca
528 Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro
165 170 175 ggc aaa gcc ccc aaa ctc atg att tat gag gtc agt aag cgg
ccc tca 576 Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Lys Arg
Pro Ser 180 185 190 ggg gtc cct gat cgc ttc tct gcc tcc aag tct ggc
aac acg gcc tcc 624 Gly Val Pro Asp Arg Phe Ser Ala Ser Lys Ser Gly
Asn Thr Ala Ser 195 200 205 ctg acc gtc tct ggg ctc cag gct gag gat
gag gct tat tat tac tgc 672 Leu Thr Val Ser Gly Leu Gln Ala Glu Asp
Glu Ala Tyr Tyr Tyr Cys 210 215 220 agc tca tat gca ggc agc aac aat
tcg gta ttc ggc gga ggg acc aag 720 Ser Ser Tyr Ala Gly Ser Asn Asn
Ser Val Phe Gly Gly Gly Thr Lys 225 230 235 240 ctg acc gtc cta ggt
735 Leu Thr Val Leu Gly 245 <210> SEQ ID NO 109 <211>
LENGTH: 738 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(738) <223> OTHER INFORMATION: Polynucleotide
encoding RGC0169 scFv protein <400> SEQUENCE: 109 cag gtg cag
ctg cag gag tcg ggt gga ggc gtg gtc cag cct ggg ggg 48 Gln Val Gln
Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcg tct gga ttc acc ttt aat att tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 20 25
30 ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ccg gag tgg gtg
144 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val
35 40 45 gca gtt att tgg tat gat gga agc aga caa tat tat gga gac
tcc gtg 192 Ala Val Ile Trp Tyr Asp Gly Ser Arg Gln Tyr Tyr Gly Asp
Ser Val 50 55 60 aag ggc cga ttc acc atc tcc aga gac aac tcc aag
aac aca gtg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Val Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg ggt gta tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Gly Val Tyr Tyr Cys 85 90 95 gcg aga gac cct agt ctg gca cct
gtg tac cag ttt gac tac tgg ggc 336 Ala Arg Asp Pro Ser Leu Ala Pro
Val Tyr Gln Phe Asp Tyr Trp Gly 100 105 110 cgg ggg aca atg gtc acc
gtc tcg agt gga ggc ggc ggt tca ggc gga 384 Arg Gly Thr Met Val Thr
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 ggt ggc tct ggc
ggt ggc gga agt gca ctt gat gtt gtg atg act cag 432 Gly Gly Ser Gly
Gly Gly Gly Ser Ala Leu Asp Val Val Met Thr Gln 130 135 140 tct cct
tcc tcc ctg tct gca tct gtg gga gag aga gtc acc atc aca 480 Ser Pro
Ser Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr 145 150 155
160 tgc cgg gca agt cag aac att ttc aac aat tta aat tgg tat caa cag
528 Cys Arg Ala Ser Gln Asn Ile Phe Asn Asn Leu Asn Trp Tyr Gln Gln
165 170 175 aaa cca ggg aat gcc cct agc ctc ctg atc tct gat gca tcc
agt ttg 576 Lys Pro Gly Asn Ala Pro Ser Leu Leu Ile Ser Asp Ala Ser
Ser Leu 180 185 190 caa agt ggg gcc cca tca agg ttc agt ggc agt gga
tct ggg aca gat 624 Gln Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
Ser Gly Thr Asp 195 200 205 tat act ctc acc atc agc agt ctg cag cct
gaa gat ctt gga act tac 672 Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
Glu Asp Leu Gly Thr Tyr 210 215 220 tac tgt caa cag agt tac acc atc
cct ccg acc ttc ggc caa ggg aca 720 Tyr Cys Gln Gln Ser Tyr Thr Ile
Pro Pro Thr Phe Gly Gln Gly Thr 225 230 235 240 cga ctg gag att aaa
cgt 738 Arg Leu Glu Ile Lys Arg 245 <210> SEQ ID NO 110
<211> LENGTH: 744 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(744) <223> OTHER INFORMATION:
Polynucleotide encoding RGC0175 scFv protein <400> SEQUENCE:
110 gag gtg cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc
48 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 tca gtg aag gtc tcc tgc aag gct tct ggt tac acc ttt acc
agc tat 96 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Ser Tyr 20 25 30 ggt atc aac tgg gtg cga cag gcc cct gga cag ggg
ctt gag tgg atg 144 Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Met 35 40 45 ggg tgg atc agc cct tac aat tat aac aca
aac tat gca cag aag ttg 192 Gly Trp Ile Ser Pro Tyr Asn Tyr Asn Thr
Asn Tyr Ala Gln Lys Leu 50 55 60 cag ggc aga gtc acc atg acc aca
gac aca tcc acg agc aca gcc tac 240 Gln Gly Arg Val Thr Met Thr Thr
Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 atg gag ctg agg agc ctg
aga tct gac gac acg gcc gtg tat tat tgt 288 Met Glu Leu Arg Ser Leu
Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gag gaa
acg ggg agt tat cat ggg ttt gac tac tgg ggc agg 336 Ala Arg Glu Glu
Thr Gly Ser Tyr His Gly Phe Asp Tyr Trp Gly Arg 100 105 110 gga acc
ctg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc gga ggt 384 Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125
ggc tct ggc ggt ggc gga agt gca ctt aat ttt atg ctg act cag ccc 432
Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro 130
135 140 cac tct gtg tcg gag tct ccg ggg aag acg gta acc atc tcc tgc
acc 480
His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr 145
150 155 160 gcc agc agt ggc aat att gcc ttc aac tat gtg cag tgg tac
cag cag 528 Ala Ser Ser Gly Asn Ile Ala Phe Asn Tyr Val Gln Trp Tyr
Gln Gln 165 170 175 cgc ccg ggc agt gcc ccc acc att gtg atc caa gag
gat aac caa aga 576 Arg Pro Gly Ser Ala Pro Thr Ile Val Ile Gln Glu
Asp Asn Gln Arg 180 185 190 ccc tct ggg gtc cct gat cgg ttc tct ggc
tcc atc gac agg tcc tcc 624 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly
Ser Ile Asp Arg Ser Ser 195 200 205 aac tct gcc tcc ctc acc atc tct
gga ctg aag gct gag gac gaa ggt 672 Asn Ser Ala Ser Leu Thr Ile Ser
Gly Leu Lys Ala Glu Asp Glu Gly 210 215 220 gac tat tac tgt cag tct
tat gat aag tac tac cgg atc ttc ggc ggc 720 Asp Tyr Tyr Cys Gln Ser
Tyr Asp Lys Tyr Tyr Arg Ile Phe Gly Gly 225 230 235 240 ggg acc aag
ctg acc gtc cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly 245
<210> SEQ ID NO 111 <211> LENGTH: 729 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(729)
<223> OTHER INFORMATION: Polynucleotide encoding RGD0102 scFv
protein <400> SEQUENCE: 111 gag gtc cag ctg gta cag tct gga
ggt gag gtg aag aag cct ggg gac 48 Glu Val Gln Leu Val Gln Ser Gly
Gly Glu Val Lys Lys Pro Gly Asp 1 5 10 15 tca gtg aag gtc tcc tgc
aag gct tct ggt tac acc ttt tct cac tat 96 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Ser His Tyr 20 25 30 ggt ata agt tgg
gtg cga cag gcc cct gga caa ggg ctt gag tgg atg 144 Gly Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 gga tgg
acc agc gct tac agt ggt agc aca aac tat gca cag aag ttc 192 Gly Trp
Thr Ser Ala Tyr Ser Gly Ser Thr Asn Tyr Ala Gln Lys Phe 50 55 60
cgg ggc aga gtc acc atg acc aca gac aca tcc acg ggc aca gca tac 240
Arg Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Gly Thr Ala Tyr 65
70 75 80 atg gaa ctg agg agc ctg aga cct gac gac acg gcc gtc tat
tac tgt 288 Met Glu Leu Arg Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 ggg aga gga gac agt tat ggt tcg ata ccc gct gat
tac tgg ggc cgg 336 Gly Arg Gly Asp Ser Tyr Gly Ser Ile Pro Ala Asp
Tyr Trp Gly Arg 100 105 110 gga acc ctg gtc acc gtc tcg agt ggt gga
ggc ggt tca ggc gga ggt 384 Gly Thr Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 ggc agc ggc ggt ggc gga tcg gat
gtt gtg atg act cag tct cca tcc 432 Gly Ser Gly Gly Gly Gly Ser Asp
Val Val Met Thr Gln Ser Pro Ser 130 135 140 tcc ctg tct gca tct cta
gga gac aga gtc acc atc act tgc cgg gca 480 Ser Leu Ser Ala Ser Leu
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 145 150 155 160 agt cag gac
att aca aat gac tta gcc tgg tat cag cag aaa cca ggg 528 Ser Gln Asp
Ile Thr Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 165 170 175 aaa
gcc cct aaa ctc ctg atc tat ggt gca tcc act ttg caa tat ggg 576 Lys
Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Gln Tyr Gly 180 185
190 gtc cca acc agg ttc agc ggc agt ggg tct ggg aca aac ttc tct ctc
624 Val Pro Thr Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Ser Leu
195 200 205 act atc agc agc ctg cag cct gag gat ttt gcg act tac ttt
tgt caa 672 Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe
Cys Gln 210 215 220 cag tct cac agt ttc cct ccc act ttc ggc gga ggg
acc aag ctg gag 720 Gln Ser His Ser Phe Pro Pro Thr Phe Gly Gly Gly
Thr Lys Leu Glu 225 230 235 240 atc aaa cgt 729 Ile Lys Arg
<210> SEQ ID NO 112 <211> LENGTH: 762 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(762)
<223> OTHER INFORMATION: Polynucleotide encoding RGD0108 scFv
protein <400> SEQUENCE: 112 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga aat tat tac gat ttt tgg cgt ggt tat caa
tca cag ccc aac 336 Ala Arg Asn Tyr Tyr Asp Phe Trp Arg Gly Tyr Gln
Ser Gln Pro Asn 100 105 110 tac atg gac gtc tgg ggc caa ggg aca atg
gtc acc gtc tcg agt gga 384 Tyr Met Asp Val Trp Gly Gln Gly Thr Met
Val Thr Val Ser Ser Gly 115 120 125 ggc ggc ggt tca ggc gga ggt ggc
tct ggc ggt ggc gga agt gca cag 432 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ala Gln 130 135 140 tct gtg ctg acg cag ccg
ccc tca gcg tct ggg acc ccc gag cag agg 480 Ser Val Leu Thr Gln Pro
Pro Ser Ala Ser Gly Thr Pro Glu Gln Arg 145 150 155 160 gtc acc atc
tcc tgt tct gga agc agc tcc aac atc gga tat aat tat 528 Val Thr Ile
Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Tyr Asn Tyr 165 170 175 gta
tac tgg ttc cag cac ctc ccc gga acg gcc ccc aag ctc ctc atc 576 Val
Tyr Trp Phe Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 180 185
190 tat acg aat aat ctg cgg ccc tcg ggg gtc cct gac caa ttc tct ggc
624 Tyr Thr Asn Asn Leu Arg Pro Ser Gly Val Pro Asp Gln Phe Ser Gly
195 200 205 tcc aag tct ggc acc tca gcc tcc ctg gcc atc agt ggg ctc
cgg tcc 672 Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
Arg Ser 210 215 220 gag gat gag ggt gat tat tac tgt gca gct tgg gat
gac agc ctg agt 720 Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ala Trp Asp
Asp Ser Leu Ser 225 230 235 240 ggt cgg gtg ttc ggc gga ggg acc aag
gtc acc gtc cta ggt 762 Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr
Val Leu Gly 245 250 <210> SEQ ID NO 113 <211> LENGTH:
744 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(744) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0112 scFv protein <400> SEQUENCE: 113 gag gtg cag
ctg ttg gag tct ggg gga agc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Ser Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gca aga gag gat cct tgg agc gac
gct ttt gat ttg tgg ggc cga gga 336 Ala Arg Glu Asp Pro Trp Ser Asp
Ala Phe Asp Leu Trp Gly Arg Gly 100 105 110 acc ctg gtc acc gtc tcg
agt gga ggc ggc ggt tca ggc gga ggt ggc 384 Thr Leu Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc
gga agt gca ctt aat ttt atg ctg act cag ccc cac 432 Ser Gly Gly Gly
Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 130 135 140 tct gtg
tcg gag tct ccg ggg aag acg gta acc atc tcc tgc acc ggc 480 Ser Val
Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 145 150 155
160 agc agt ggc agc att gcc agc aac tat gtg cag tgg tac cag cag cgc
528 Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg
165 170 175 ccg ggc agt gcc ccc acc act gtg atc tat gag gat aac caa
aga ccc 576 Pro Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln
Arg Pro 180 185 190 tct ggg gtc cct gat cgc ttc tct ggc tcc atc gac
agc tcc tcc aac 624 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp
Ser Ser Ser Asn 195 200 205 tct gcc tcc ctc acc atc tct gga ctg aag
act gag gac gag gct gac 672 Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys
Thr Glu Asp Glu Ala Asp 210 215 220 tac tac tgt cag tct tat gat agc
agc aat cat tgg gtg ttc ggc gga 720 Tyr Tyr Cys Gln Ser Tyr Asp Ser
Ser Asn His Trp Val Phe Gly Gly 225 230 235 240
ggg acc aag ctg acc gtc cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly
245 <210> SEQ ID NO 114 <211> LENGTH: 744 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(744)
<223> OTHER INFORMATION: Polynucleotide encoding RGD0117 scFv
protein <400> SEQUENCE: 114 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gcc cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gca aga gat agg ggg tcc cct gat gct ttt gat atc
tgg ggc cag ggg 336 Ala Arg Asp Arg Gly Ser Pro Asp Ala Phe Asp Ile
Trp Gly Gln Gly 100 105 110 aca atg gtc acc gtc tcg agt gga ggc ggc
ggt tca ggc gga ggt ggc 384 Thr Met Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc gga agt gca ctt
aat ttt atg ctg act cag ccc cac 432 Ser Gly Gly Gly Gly Ser Ala Leu
Asn Phe Met Leu Thr Gln Pro His 130 135 140 tct gtg tcg gag tct ccg
ggg aag acg gtg acc atc tcc tgc acc ggc 480 Ser Val Ser Glu Ser Pro
Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 145 150 155 160 agc agt ggc
agc att gcc agc aac tat gtg cag tgg tac cag cag cgc 528 Ser Ser Gly
Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165 170 175 ccg
ggc agt gcc ccc acc act gtg atc tat gag tat agt caa aga ccc 576 Pro
Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Tyr Ser Gln Arg Pro 180 185
190 tct ggg gtc cct gat cgg ttc tct ggc tcc atc gac agc tcc tcc aac
624 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn
195 200 205 tct gcc tcc ctc acc atc tct ggg ctg aag act gag gac gag
gct gac 672 Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu
Ala Asp 210 215 220 tac tac tgt cag tct ttt gat acc aac aat cag ggg
gtg ttc ggc gga 720 Tyr Tyr Cys Gln Ser Phe Asp Thr Asn Asn Gln Gly
Val Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt 744
Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 115
<211> LENGTH: 735 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(735) <223> OTHER INFORMATION:
Polynucleotide encoding RGD0119 scFv protein <400> SEQUENCE:
115 gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cca ggg ggg
48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc
agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg
ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 tca gct att agt ggt agt ggt ggt agc aca
tac tac gca gac tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr
Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga
gac aat tcc aag aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg
aga gcc gag gac acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aaa ggc atc
agc agc agc tgg acg tta ttt gac tac tgg ggc caa 336 Ala Lys Gly Ile
Ser Ser Ser Trp Thr Leu Phe Asp Tyr Trp Gly Gln 100 105 110 ggg aca
atg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc gga ggt 384 Gly Thr
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125
ggc tct ggc ggt ggc gga agt gca ctt gaa acg aca ctc acg cag tct 432
Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Thr Leu Thr Gln Ser 130
135 140 cca gcc acc ctg tcc ttg tct cca ggg gaa agc gcc acc ctc tcc
tgc 480 Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Ser Ala Thr Leu Ser
Cys 145 150 155 160 agg gcc agt cag agt att gga agt ctc tta gcc tgg
tac caa cag aga 528 Arg Ala Ser Gln Ser Ile Gly Ser Leu Leu Ala Trp
Tyr Gln Gln Arg 165 170 175 cct ggc cag gct ccc agg ctc gtg atc tcc
gat gca tcc aat agg gcc 576 Pro Gly Gln Ala Pro Arg Leu Val Ile Ser
Asp Ala Ser Asn Arg Ala 180 185 190 tct ggc atc cca gcc agg ttc aga
ggc agt ggg tct gga aca gac ttc 624 Ser Gly Ile Pro Ala Arg Phe Arg
Gly Ser Gly Ser Gly Thr Asp Phe 195 200 205 act ctc acc atc agc agc
cta gcg cct gaa gat ttt gca gtt tat tac 672 Thr Leu Thr Ile Ser Ser
Leu Ala Pro Glu Asp Phe Ala Val Tyr Tyr 210 215 220 tgt cat caa cgt
agc atg tgg cct ctc agt ttc ggc gga ggg acc aag 720 Cys His Gln Arg
Ser Met Trp Pro Leu Ser Phe Gly Gly Gly Thr Lys 225 230 235 240 gtg
gaa atc aaa cgt 735 Val Glu Ile Lys Arg 245 <210> SEQ ID NO
116 <211> LENGTH: 732 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(732) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0121 scFv protein
<400> SEQUENCE: 116 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga atc cac aac tgg aac gac atg ttt gac tac tgg ggc cga
ggg 336 Ala Arg Ile His Asn Trp Asn Asp Met Phe Asp Tyr Trp Gly Arg
Gly 100 105 110 aca atg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc
gga ggt ggc 384 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 115 120 125 tct ggc ggt ggc gga agt gca ctt gac atc cag
ttg acc cag tct cct 432 Ser Gly Gly Gly Gly Ser Ala Leu Asp Ile Gln
Leu Thr Gln Ser Pro 130 135 140 tcc tcc ctg tct gca tct gtt gga gac
aaa gtt acc atc gct tgc cgc 480 Ser Ser Leu Ser Ala Ser Val Gly Asp
Lys Val Thr Ile Ala Cys Arg 145 150 155 160 cca agt cag ggc att agc
agt gct tta gcc tgg tat caa cag aaa ccg 528 Pro Ser Gln Gly Ile Ser
Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 gga aaa cct cct
aga ctc ctt atc tat gat gtc tcc act ttg gaa agt 576 Gly Lys Pro Pro
Arg Leu Leu Ile Tyr Asp Val Ser Thr Leu Glu Ser 180 185 190 ggg gtc
cca tca agg ttc agc ggc agt gga tct ggg aca tat ttc act 624 Gly Val
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr 195 200 205
ctc acc atc agc agt ctg cag cct gag gat ttt gca act tat tac tgt 672
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210
215 220 caa caa ttt gat aac tac ccg gtc acc ttc ggc caa ggg aca cga
ctg 720 Gln Gln Phe Asp Asn Tyr Pro Val Thr Phe Gly Gln Gly Thr Arg
Leu 225 230 235 240 gag att aaa cgt 732 Glu Ile Lys Arg <210>
SEQ ID NO 117 <211> LENGTH: 741 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(741)
<223> OTHER INFORMATION: Polynucleotide encoding RGD0122 scFv
protein <400> SEQUENCE: 117 gag gtg cag ctg ttg gag tct ggg
gaa ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Glu Gly Leu Val Gln Pro Gly Gly 1 5 10 15
tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20
25 30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg
gtc 144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca
gac tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
Asp Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc
aag aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag
gac acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aca gat cct tac tat gat
agt agt ggt tat tac ccc ttt agc tac 336 Ala Thr Asp Pro Tyr Tyr Asp
Ser Ser Gly Tyr Tyr Pro Phe Ser Tyr 100 105 110 tgg ggg aag ggg acc
acg gtc acc gtc tcg agt gga ggc ggc ggt tca 384 Trp Gly Lys Gly Thr
Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 ggc gga ggt
ggc tct ggc ggt ggc gga agt gca cag tct gtg ctg act 432 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr 130 135 140 cag
cca ccc tca gtg tca gtg gcc cca gga cag acg gcc acg att acc 480 Gln
Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Thr 145 150
155 160 tgt ggg gga gac ttt gca act aaa agt gtg aat tgg tac caa cgg
aag 528 Cys Gly Gly Asp Phe Ala Thr Lys Ser Val Asn Trp Tyr Gln Arg
Lys 165 170 175 ccg ggc cag gcc cct gtg acg gtc atc tat tat tct acc
gag cgg ccc 576 Pro Gly Gln Ala Pro Val Thr Val Ile Tyr Tyr Ser Thr
Glu Arg Pro 180 185 190 ccc gcg atc cct gag cgc ttc tct ggc tcc aac
act ggg tcc acg gcc 624 Pro Ala Ile Pro Glu Arg Phe Ser Gly Ser Asn
Thr Gly Ser Thr Ala 195 200 205 acc ctg acc atc agc agg gtc gaa gcc
ggg gat gag gcc gac tat tat 672 Thr Leu Thr Ile Ser Arg Val Glu Ala
Gly Asp Glu Ala Asp Tyr Tyr 210 215 220 tgt cag gtg tgg gac agt ttt
act gat cat cgg ctg ttc ggc gga ggg 720 Cys Gln Val Trp Asp Ser Phe
Thr Asp His Arg Leu Phe Gly Gly Gly 225 230 235 240 acc aag ctg acc
gtc cta ggt 741 Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID
NO 118 <211> LENGTH: 744 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(744) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0123 scFv protein
<400> SEQUENCE: 118 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga tat gct agt ggc ttg ctt gat gct ttt gac ata tgg ggg
cag 336 Ala Arg Tyr Ala Ser Gly Leu Leu Asp Ala Phe Asp Ile Trp Gly
Gln 100 105 110 ggg acc acg gtc acc gtc tcg agt gga ggc ggc ggt tca
ggc gga ggt 384 Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca cag tct gtg
ctg acg cag ccg ccc 432 Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val
Leu Thr Gln Pro Pro 130 135 140 tca gtg tct ggg gcc cca ggg cag agg
gtc acc atc tcc tgc act ggg 480 Ser Val Ser Gly Ala Pro Gly Gln Arg
Val Thr Ile Ser Cys Thr Gly 145 150 155 160 agc agc tcc aac atc ggg
gca ggt aat gat gta aat tgg tac caa caa 528 Ser Ser Ser Asn Ile Gly
Ala Gly Asn Asp Val Asn Trp Tyr Gln Gln 165 170 175 gtt cca gga aga
gcc ccc aaa ctc ctc atc tat ggt acc acc tat cgg 576 Val Pro Gly Arg
Ala Pro Lys Leu Leu Ile Tyr Gly Thr Thr Tyr Arg 180 185 190 ccc tca
ggg gtc cct gac cga ttc tct ggc tcc aag tct ggc acc tca 624 Pro Ser
Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 195 200 205
gcc tcc ctg gcc atc act ggg ctc cag gct gaa gat gag gct gat tat 672
Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr 210
215 220 ttc tgc cag tcc gat gac agc agc ctg agt ggt tcg gtc ttc ggc
gga 720 Phe Cys Gln Ser Asp Asp Ser Ser Leu Ser Gly Ser Val Phe Gly
Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt 744 Gly Thr Lys
Leu Thr Val Leu Gly 245 <210> SEQ ID NO 119 <211>
LENGTH: 762 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(762) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0124 scFv protein <400> SEQUENCE: 119 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 ccc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Pro
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gtg aaa gat acg gag ttt tat tac
gat ttt tgg agt aat gac ggg ggc 336 Val Lys Asp Thr Glu Phe Tyr Tyr
Asp Phe Trp Ser Asn Asp Gly Gly 100 105 110 tgg ttc gac acc tgg ggc
cgg ggg aca atg gtc acc gtc tcg agt gga 384 Trp Phe Asp Thr Trp Gly
Arg Gly Thr Met Val Thr Val Ser Ser Gly 115 120 125 ggc ggc ggt tca
ggc gga ggt ggc tct ggc ggt ggc gga agt gca cag 432 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln 130 135 140 gct gtg
ctg act cag ccg tcc tca acg tct ggg tcc ccc ggg cag agg 480 Ala Val
Leu Thr Gln Pro Ser Ser Thr Ser Gly Ser Pro Gly Gln Arg 145 150 155
160 gtc acc atc tct tgt tct gga agc aac tcc aac atc gga agt aat tat
528 Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn Tyr
165 170 175 gtc tac tgg tac cag caa ctc ccg gga acg gcc ccc aaa ctc
ctc att 576 Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
Leu Ile 180 185 190 tat agg aat aat cag cgg ccc tca ggg gtc cct gac
cga ttc tct ggc 624 Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp
Arg Phe Ser Gly 195 200 205 tcc aag tct ggc acc tca gcc tcc ctg gcc
atc agt ggg ctc cgg tcc 672 Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala
Ile Ser Gly Leu Arg Ser 210 215 220 ggc gat gag ggt gat tat cac tgt
gca acg tgg gat gac agg ctg tat 720 Gly Asp Glu Gly Asp Tyr His Cys
Ala Thr Trp Asp Asp Arg Leu Tyr 225 230 235 240 ggt tgg gtg ttc ggc
gga ggg acc aag gtc acc gtc cta ggt 762 Gly Trp Val Phe Gly Gly Gly
Thr Lys Val Thr Val Leu Gly 245 250 <210> SEQ ID NO 120
<211> LENGTH: 735 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(735) <223> OTHER INFORMATION:
Polynucleotide encoding RGD0130 scFv protein <400> SEQUENCE:
120 gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cca ggg ggg
48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc
agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg
ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 tca gct att agt ggt agt ggt ggt agc aca
tac tac gca gac tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr
Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga
gac aat tcc aag aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg
aga gcc gag gac acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
gcg aaa ggc atc agc agc agc tgg acg tta ttt gac tac tgg ggc caa 336
Ala Lys Gly Ile Ser Ser Ser Trp Thr Leu Phe Asp Tyr Trp Gly Gln 100
105 110 ggg aca atg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc gga
ggt 384 Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca ctt gaa acg aca ctc
acg cag tct 432 Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Thr Leu
Thr Gln Ser 130 135 140 cca gcc acc ctg tcc ttg tct cca ggg gaa agc
gcc acc ctc tcc tgc 480 Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Ser
Ala Thr Leu Ser Cys 145 150 155 160 agg gcc agt cag agt att gga agt
ctc tta gcc tgg tac caa cag aga 528 Arg Ala Ser Gln Ser Ile Gly Ser
Leu Leu Ala Trp Tyr Gln Gln Arg 165 170 175 cct ggc cag gct ccc agg
ctc gtg atc tcc gat gca tcc aat agg gcc 576 Pro Gly Gln Ala Pro Arg
Leu Val Ile Ser Asp Ala Ser Asn Arg Ala 180 185 190 tct ggc atc cca
gcc agg ttc aga ggc agt ggg tct gga aca gac ttc 624 Ser Gly Ile Pro
Ala Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe 195 200 205 act ctc
acc atc agc agc cta gcg cct gaa gat ttt gca gtt tat tac 672 Thr Leu
Thr Ile Ser Ser Leu Ala Pro Glu Asp Phe Ala Val Tyr Tyr 210 215 220
tgt caa caa cgt agc atg tgg cct ctc agt ttc ggc gga ggg acc aag 720
Cys Gln Gln Arg Ser Met Trp Pro Leu Ser Phe Gly Gly Gly Thr Lys 225
230 235 240 gtg gaa atc aaa cgt 735 Val Glu Ile Lys Arg 245
<210> SEQ ID NO 121 <211> LENGTH: 747 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(747)
<223> OTHER INFORMATION: Polynucleotide encoding RGD0135 scFv
protein <400> SEQUENCE: 121 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga tat gct agt ggc ttg gtt gat gct ttt gac
atg tgg ggc cgg 336 Ala Arg Tyr Ala Ser Gly Leu Val Asp Ala Phe Asp
Met Trp Gly Arg 100 105 110 ggg aca atg gtc acc gtc tcg agt gga ggc
ggc ggt tca ggc gga ggt 384 Gly Thr Met Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 ggc tct ggc ggt ggc gga agt gca
cag gct gtg ctg act cag ccg tcc 432 Gly Ser Gly Gly Gly Gly Ser Ala
Gln Ala Val Leu Thr Gln Pro Ser 130 135 140 tca gtg tcc ggg gcc cca
ggg cag agg gtc acc atc tcc tgc act ggg 480 Ser Val Ser Gly Ala Pro
Gly Gln Arg Val Thr Ile Ser Cys Thr Gly 145 150 155 160 cgc agc tcc
aac atc ggg gca ggt tat gat gtt aat tgg tac cag cag 528 Arg Ser Ser
Asn Ile Gly Ala Gly Tyr Asp Val Asn Trp Tyr Gln Gln 165 170 175 ctt
cca gga gca gcc ccc aaa ctc ctc atc tat gat aac aac tat cgg 576 Leu
Pro Gly Ala Ala Pro Lys Leu Leu Ile Tyr Asp Asn Asn Tyr Arg 180 185
190 ccc tcg ggg gtc cct gac cga ttc tct ggc tcc aag tct ggc acc tca
624 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser
195 200 205 gcc tcc ctg gcc ata act ggg ctc cag gct gac gat gag gct
gtt tat 672 Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Asp Asp Glu Ala
Val Tyr 210 215 220 tac tgc cag tct tat gac agc agc ctg agt ggt tca
gag gtc ttc ggc 720 Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser
Glu Val Phe Gly 225 230 235 240 gga ggg acc aag gtc acc gtc cta ggt
747 Gly Gly Thr Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO
122 <211> LENGTH: 753 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(753) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0136 scFv protein
<400> SEQUENCE: 122 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac gcg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85
90 95 gcg aaa gat tcc ctg gga cta tgg ttc gga ctc gga cac ttt gag
aac 336 Ala Lys Asp Ser Leu Gly Leu Trp Phe Gly Leu Gly His Phe Glu
Asn 100 105 110 tgg ggc cgg ggc acc ctg gtc acc gtc tcg agt gga ggc
ggc ggt tca 384 Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser 115 120 125 ggc gga ggt ggc tct ggc ggt ggc gga agt gca
ctt aat ttt atg ctg 432 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
Leu Asn Phe Met Leu 130 135 140 act cag ccc cac tct gtg tcg gag tct
ccg ggt aag aca gta act ctc 480 Thr Gln Pro His Ser Val Ser Glu Ser
Pro Gly Lys Thr Val Thr Leu 145 150 155 160 tcc tgc acc cgc tcc agt
ggc agc att tca ttc gac tat gtg cag tgg 528 Ser Cys Thr Arg Ser Ser
Gly Ser Ile Ser Phe Asp Tyr Val Gln Trp 165 170 175 tat caa cag cgg
ccg ggc agc tcc ccc att ctt gtg atc ttt gaa gat 576 Tyr Gln Gln Arg
Pro Gly Ser Ser Pro Ile Leu Val Ile Phe Glu Asp 180 185 190 gac caa
aga ccc tct ggg gtc cct gat cga ttc tct ggc tcc atc gac 624 Asp Gln
Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp 195 200 205
agt acc tcc aac tct gcc tcc ctc acc atc tct ggc ctg cag agt gag 672
Ser Thr Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu 210
215 220 gac gag ggt gac tac tat tgt cag act tat gat gac aac cgt cag
gtg 720 Asp Glu Gly Asp Tyr Tyr Cys Gln Thr Tyr Asp Asp Asn Arg Gln
Val 225 230 235 240 ttc ggc gga ggg acc aag ctg acc gtc cta ggt 753
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250 <210> SEQ
ID NO 123 <211> LENGTH: 744 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(744) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0141 scFv protein
<400> SEQUENCE: 123 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga gac tcc ctc tac ggt gac ctc gaa tac ttc cag cac tgg
ggg 336 Ala Arg Asp Ser Leu Tyr Gly Asp Leu Glu Tyr Phe Gln His Trp
Gly 100 105 110 cga ggg acc acg gtc acc gtc tcg agt gga ggc ggc ggt
tca ggc gga 384 Arg Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
Ser Gly Gly 115 120 125 ggt ggc tct ggc ggt ggc gga agt gca cag tct
gtg ctg act cag cca 432 Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser
Val Leu Thr Gln Pro 130 135 140 tcc tca gcg tct ggg aac ccc gga cag
agg gtc acc att tct tgt tct 480 Ser Ser Ala Ser Gly Asn Pro Gly Gln
Arg Val Thr Ile Ser Cys Ser 145 150 155 160 gga agc agc tcc aac atc
ggg gat aat cct gtg gac tgg tat cag cat 528 Gly Ser Ser Ser Asn Ile
Gly Asp Asn Pro Val Asp Trp Tyr Gln His 165 170 175
gtc cca gga agg gcc ccc aaa ctc ctc atc ttt agg gat aat cag cgg 576
Val Pro Gly Arg Ala Pro Lys Leu Leu Ile Phe Arg Asp Asn Gln Arg 180
185 190 ccc tca ggg gtc cct gac cga ttc tct ggc acc aag tct ggc acc
tca 624 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Thr Lys Ser Gly Thr
Ser 195 200 205 gcc tcc ctg gcc atc agt ggc ctc cag tct gag gat gag
gct gat tat 672 Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu
Ala Asp Tyr 210 215 220 tac tgt gaa gca tgg gat gac agc ctg gat agt
ccg gtg ttc ggc gga 720 Tyr Cys Glu Ala Trp Asp Asp Ser Leu Asp Ser
Pro Val Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt
744 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO 124
<211> LENGTH: 759 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(759) <223> OTHER INFORMATION:
Polynucleotide encoding RGD0143 scFv protein <400> SEQUENCE:
124 gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg
48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc
agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Ser Tyr 20 25 30 gcc atg agc tgg gcc cgc cag gct cca ggg aag ggg
ctg gag tgg gtc 144 Ala Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 tca gct att agt ggt agt ggt ggt agc aca
tac tac gca gac tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr
Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga
gac aat tcc aag aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg
aga gcc gag gac acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga cat cgg
ggg att aca atg tat gga gtg ctc cgt cct ggc gat 336 Ala Arg His Arg
Gly Ile Thr Met Tyr Gly Val Leu Arg Pro Gly Asp 100 105 110 atg gac
gtc tgg ggc cga gga acc ctg gtc acc gtc tcg agt gga ggc 384 Met Asp
Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly 115 120 125
ggc ggt tca ggc gga ggt ggc tct ggc ggt ggc gga agt gca cag gct 432
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ala 130
135 140 gtg ctg act cag ccg tcc tca gcg tct gcg acc ccc ggg cag agg
gtc 480 Val Leu Thr Gln Pro Ser Ser Ala Ser Ala Thr Pro Gly Gln Arg
Val 145 150 155 160 acc atc tct tgt tct gga agc agc tcc aac atc gga
agt aat agt gta 528 Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly
Ser Asn Ser Val 165 170 175 aac tgg tac cag cac ctc cca gga acg gcc
ccc aaa ctc ctc atc tat 576 Asn Trp Tyr Gln His Leu Pro Gly Thr Ala
Pro Lys Leu Leu Ile Tyr 180 185 190 act aat gat cag cgg ccc tca ggg
gtc cct gac cga ttc tct ggc tcc 624 Thr Asn Asp Gln Arg Pro Ser Gly
Val Pro Asp Arg Phe Ser Gly Ser 195 200 205 aag tct ggc acc tca gcc
tcc ctg gcc atc agt ggg ctc cag tct gag 672 Lys Ser Gly Thr Ser Ala
Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu 210 215 220 gat gag gct gat
tat tac tgt gca gca tgg gat gac acc ctg act ggt 720 Asp Glu Ala Asp
Tyr Tyr Cys Ala Ala Trp Asp Asp Thr Leu Thr Gly 225 230 235 240 ccg
gtc ttc ggc gga ggg acc aag ctg acc gtc cta ggt 759 Pro Val Phe Gly
Gly Gly Thr Lys Leu Thr Val Leu Gly 245 250 <210> SEQ ID NO
125 <211> LENGTH: 726 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(726) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0145 scFv protein
<400> SEQUENCE: 125 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga aga tac cga tac ttt gac aac tgg ggc cag ggg aca atg
gtc 336 Ala Arg Arg Tyr Arg Tyr Phe Asp Asn Trp Gly Gln Gly Thr Met
Val 100 105 110 acc gtc tcg agt gga ggc ggc ggt tca ggc gga ggt ggc
tct ggc ggt 384 Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly 115 120 125 ggc gga agt gca ctt tct tct gag ctg act cag
gac cct gct gtg tct 432 Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln
Asp Pro Ala Val Ser 130 135 140 gtg gcc ttg gga cag aca gtc agg atc
aca tgc caa gga gac agc ctc 480 Val Ala Leu Gly Gln Thr Val Arg Ile
Thr Cys Gln Gly Asp Ser Leu 145 150 155 160 aga acc tat tat gca agc
tgg tac cag cag aag cca gga cag gcc cct 528 Arg Thr Tyr Tyr Ala Ser
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 165 170 175 gtt ctt gtc ttc
tat ggt aaa aaa aat cgg ccc tca ggg atc cca gac 576 Val Leu Val Phe
Tyr Gly Lys Lys Asn Arg Pro Ser Gly Ile Pro Asp 180 185 190 cga ttc
tct ggc tcc agc tca gga aac aca tct tcc ttg acc atc act 624 Arg Phe
Ser Gly Ser Ser Ser Gly Asn Thr Ser Ser Leu Thr Ile Thr 195 200 205
ggg gct cag gca gaa gat gac gct gac tat tac tgt aac tcc cgg gac 672
Gly Ala Gln Ala Glu Asp Asp Ala Asp Tyr Tyr Cys Asn Ser Arg Asp 210
215 220 agc agt ggt aac cat ctg gta ttc ggc gga ggg acc aag ctg acc
gtc 720 Ser Ser Gly Asn His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr
Val 225 230 235 240 cta ggt 726 Leu Gly <210> SEQ ID NO 126
<211> LENGTH: 753 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(753) <223> OTHER INFORMATION:
Polynucleotide encoding RGD0153 scFv protein <400> SEQUENCE:
126 gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg
48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc
agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg
ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 tca gct att agt ggt agt ggt ggt acc aca
tac tac gca gac tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr
Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga
gac aat tcc aag aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg
aga gcc gag gac acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga ttg cgg
ggt agt acc agg tgg gaa gac ttc tat tac ttt gac 336 Ala Arg Leu Arg
Gly Ser Thr Arg Trp Glu Asp Phe Tyr Tyr Phe Asp 100 105 110 tac tgg
ggc aaa ggg aca atg gtc acc gtc tcg agt gga ggc ggc ggt 384 Tyr Trp
Gly Lys Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125
tca ggc gga ggt ggc tct ggc ggt ggc gga agt gca cag act gtg gtg 432
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Thr Val Val 130
135 140 atc cag gag cca tct ttc tca gtg tcc cct gga ggg aca gtc aca
ctc 480 Ile Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly Thr Val Thr
Leu 145 150 155 160 act tgt ggc ctg agc tct ggc tca gtc tct act act
tac tac ccc agc 528 Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Thr
Tyr Tyr Pro Ser 165 170 175 tgg tac cag cag acc cca ggc cag gct cca
cgc acg ctc atc tac aac 576 Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro
Arg Thr Leu Ile Tyr Asn 180 185 190 aca aac act cgc tct tct ggg gtc
cct gat cgc ttc tct ggc tcc atc 624 Thr Asn Thr Arg Ser Ser Gly Val
Pro Asp Arg Phe Ser Gly Ser Ile 195 200 205 ctt ggg aac aaa gct gcc
ctc acc atc acg ggg gcc cag gca gat gat 672 Leu Gly Asn Lys Ala Ala
Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp 210 215 220 gaa tct gat tat
tac tgt gtg ctg tat ctg ggt agt ggc att tgg gtg 720 Glu Ser Asp Tyr
Tyr Cys Val Leu Tyr Leu Gly Ser Gly Ile Trp Val 225 230 235 240 ttc
ggc gga ggg acc aag ctg acc gtc cta ggt 753 Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu Gly 245 250 <210> SEQ ID NO 127
<211> LENGTH: 741 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(741) <223> OTHER INFORMATION:
Polynucleotide encoding RGD0154 scFv protein <400> SEQUENCE:
127 gag gtg cag ctg ttg gag tct ggg gga ggc ttg gtg cag cct ggg ggg
48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc
agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg
ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 tcg gct att agt ggt agt ggt ggt agc aca
tac tac gca gac tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr
Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga
gac aat tcc aag aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg
aga gcc gag gac acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aca gat cct
tac tat gat agt agt ggt tat tac ccc ttt agc tac 336 Ala Thr Asp Pro
Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro Phe Ser Tyr 100 105 110 tgg ggc
cgg ggg aca atg gtc acc gtc tcg agt gga ggc ggc ggt tca 384 Trp Gly
Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125
ggc gga ggt ggc tct ggc ggt ggc gga agt gca cag tct gtc gtg acg 432
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Val Thr 130
135 140 cag ccg ccc tca gtg tca gtg gcc cca gga aag acg gcc acg att
acc 480 Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Thr Ile
Thr 145 150 155 160 tgt ggg gga gac ttt gca act aaa agt gtg aat tgg
tac caa cgg aag 528 Cys Gly Gly Asp Phe Ala Thr Lys Ser Val Asn Trp
Tyr Gln Arg Lys 165 170 175 ccg ggc cag gcc cct gtg acg gtc atc tat
tat aat acc gag cgg ccc 576 Pro Gly Gln Ala Pro Val Thr Val Ile Tyr
Tyr Asn Thr Glu Arg Pro 180 185 190 cca gcg atc cct gag cgc ttc tct
ggc tcc aac act ggg tcc acg gcc 624 Pro Ala Ile Pro Glu Arg Phe Ser
Gly Ser Asn Thr Gly Ser Thr Ala 195 200 205 acc ctg acc atc agc agg
gtc gaa gcc ggg gat gag gcc gac tat tat 672 Thr Leu Thr Ile Ser Arg
Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 210 215 220 tgt cag gtg tgg
gac agt ttt act gat cat cgg ctg ttc ggc gga ggg 720 Cys Gln Val Trp
Asp Ser Phe Thr Asp His Arg Leu Phe Gly Gly Gly 225 230 235 240 acc
aag gtc acc gtc cta ggt 741 Thr Lys Val Thr Val Leu Gly 245
<210> SEQ ID NO 128 <211> LENGTH: 753 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(753)
<223> OTHER INFORMATION: Polynucleotide encoding RGD0169 scFv
protein <400> SEQUENCE: 128 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga gat aga gtg agg cgc gtt ccc ttt ggt tcg
ggg agc tat tta 336 Ala Arg Asp Arg Val Arg Arg Val Pro Phe Gly Ser
Gly Ser Tyr Leu 100 105 110 aac ccc ttt gac tgg ggc caa ggg aca atg
gtc acc gtc tcg agt gga 384 Asn Pro Phe Asp Trp Gly Gln Gly Thr Met
Val Thr Val Ser Ser Gly 115 120 125 ggc ggc ggt tca ggc gga ggt ggc
tct ggc ggt ggc gga agt gca ctt 432 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ala Leu 130 135 140 tcc tat gag ctg act cag
cca ccc tca gtg tcc gtg tcc cca gga caa 480 Ser Tyr Glu Leu Thr Gln
Pro Pro Ser Val Ser Val Ser Pro Gly Gln 145 150 155 160 aca gcc agc
atc acc tgt act ggg gat aaa ttg gcg gag aaa tat gtt 528 Thr Ala Ser
Ile Thr Cys Thr Gly Asp Lys Leu Ala Glu Lys Tyr Val 165 170 175 tct
tgg tat cag cag aag aca ggc cgg tcc cct gtg ttg gtc atc tat 576 Ser
Trp Tyr Gln Gln Lys Thr Gly Arg Ser Pro Val Leu Val Ile Tyr 180 185
190 caa gat gac agg cgg ccc tca gag atc cct gag cga ttc tct ggc tcc
624 Gln Asp Asp Arg Arg Pro Ser Glu Ile Pro Glu Arg Phe Ser Gly Ser
195 200 205 aac tct ggg aac aca gcc act ttg acc gtc agc ggg gcc cag
tct atg 672 Asn Ser Gly Asn Thr Ala Thr Leu Thr Val Ser Gly Ala Gln
Ser Met 210 215 220 gat gag gct gac tac tac tgt caa gta tgg gac agc
aac act gtg ata 720 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser
Asn Thr Val Ile 225 230 235 240 ttc ggc gga ggg acc aag gtc acc gtc
cta ggt 753 Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 245 250
<210> SEQ ID NO 129 <211> LENGTH: 747 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(747)
<223> OTHER INFORMATION: Polynucleotide encoding RGD0170 scFv
protein <400> SEQUENCE: 129 gag gtg cag ctg ttg gag tct ggg
gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt
gca gcc tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct
att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala
Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65
70 75 80 ctg caa atg aac agc ctg aga acc gag gac acg gcc gtg tat
tac tgt 288 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 gcg aga cag cag ccc ttc acc gac gcg ttc gac att
tgg ggc caa ggg 336 Ala Arg Gln Gln Pro Phe Thr Asp Ala Phe Asp Ile
Trp Gly Gln Gly 100 105 110 aca atg gtc acc gtc tcg agt gga ggc ggc
ggt tca ggc gga ggt ggc 384 Thr Met Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc gga agt gca ctt
aat ttt atg ctg act cag ccc cac 432 Ser Gly Gly Gly Gly Ser Ala Leu
Asn Phe Met Leu Thr Gln Pro His 130 135 140 tct gtg tcg gag tct ccg
ggg aag acg gta acc atc tcc tgc acc ggc 480 Ser Val Ser Glu Ser Pro
Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 145 150 155 160 agc agt ggc
aac att gcc aac aac tat gtg cag tgg ttc caa cag cgc 528 Ser Ser Gly
Asn Ile Ala Asn Asn Tyr Val Gln Trp Phe Gln Gln Arg 165 170 175 ccg
ggc agt gcc ccc acc act gtg atc tat gag gat aac caa aga ccc 576 Pro
Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro 180 185
190 tct ggg gtc cct gat cgg ttc tct ggc tcc atc gac agc tcc tcc aac
624 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn
195 200 205 tct gcc tcc ctc acc atc tct gga ctg aag act gag gac gag
gct gac 672 Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu
Ala Asp 210 215 220 tac tac tgt cag tct tat gat agc agc aat ctt tat
gtg gta ttc ggc 720 Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Leu Tyr
Val Val Phe Gly 225 230 235 240 gga ggg acc aag gtc acc gtc cta ggt
747 Gly Gly Thr Lys Val Thr Val Leu Gly 245 <210> SEQ ID NO
130 <211> LENGTH: 744 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(744) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0180 scFv protein
<400> SEQUENCE: 130 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35
40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac tcc
gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser
Val 50 55 60 aag ggc cgg ttc acc atc tcc gga gac aat tcc aag aac
acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys Asn
Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg
gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 gcg aga cta ggt aac tgg aac gac gtc
ttt gac tac tgg ggc caa ggg 336 Ala Arg Leu Gly Asn Trp Asn Asp Val
Phe Asp Tyr Trp Gly Gln Gly 100 105 110 aca atg gtc acc gtc tcg agt
gga ggc ggc ggt tca ggc gga ggt ggc 384 Thr Met Val Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 tct ggc ggt ggc gga
agt gca ctt aat ttt atg ctg act cag ccc cac 432 Ser Gly Gly Gly Gly
Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 130 135 140 tct gtg tcg
gag tct ccg ggg aag acg gta acc atc tcc tgc acc cgc 480 Ser Val Ser
Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Arg 145 150 155 160
agc agt ggc agc att gcc aac aac tat gtg cag tgg tac cag cag cgc 528
Ser Ser Gly Ser Ile Ala Asn Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165
170 175 ccg ggc agt gcc ccc acc act gtg atc ttt gag gat gac caa aga
ccc 576 Pro Gly Ser Ala Pro Thr Thr Val Ile Phe Glu Asp Asp Gln Arg
Pro 180 185 190 tct ggg gtc cct gat cgg ttc tct ggc tcc atc gac cgc
tcc tcc aac 624 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg
Ser Ser Asn 195 200 205 tct gcc tcc ctc acc atc tct gga ctg aag act
gac gac gag gct gac 672 Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr
Asp Asp Glu Ala Asp 210 215 220 tac tac tgt cag tct aat gat ggc acc
aat cct tgg gtg ttc ggc gga 720 Tyr Tyr Cys Gln Ser Asn Asp Gly Thr
Asn Pro Trp Val Phe Gly Gly 225 230 235 240 ggg acc aag ctg acc gtc
cta ggt 744 Gly Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID
NO 131 <211> LENGTH: 744 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(744) <223> OTHER
INFORMATION: Polynucleotide encoding RGD0182 scFv protein
<400> SEQUENCE: 131 gag gtg cag ctg ttg gag tct ggg gga ggc
ttg gta cag cct ggg ggg 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttt agc agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 gcc atg agc tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca gct att agt
ggt agt ggt ggt agc aca tac tac gca gac tcc gtg 192 Ser Ala Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gca aga gag gat cct tgg agt gac gct ttt gat ttg tgg ggc aaa
ggg 336 Ala Arg Glu Asp Pro Trp Ser Asp Ala Phe Asp Leu Trp Gly Lys
Gly 100 105 110 aca atg gtc acc gtc tcg agt gga ggc ggc ggt tca ggc
gga ggt ggc 384 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 115 120 125 tct ggc ggt ggc gga agt gca ctt aat ttt atg
ctg act cag ccc cac 432 Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met
Leu Thr Gln Pro His 130 135 140 tct gtg tcg gag tct ccg ggg aag acg
gtc acc atc tcc tgc acc ggc 480 Ser Val Ser Glu Ser Pro Gly Lys Thr
Val Thr Ile Ser Cys Thr Gly 145 150 155 160 agc agt ggc agc att gcc
aac aac tat gtg cag tgg tac caa cag cgc 528 Ser Ser Gly Ser Ile Ala
Asn Asn Tyr Val Gln Trp Tyr Gln Gln Arg 165 170 175 ccg ggc agt gcc
ccc acc act gtg att tat gag gat aac caa aga ccc 576 Pro Gly Ser Ala
Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro 180 185 190 tct gga
gtc cct gat cgg ttc tct gcc tcc atc gac agg tcc tcc aac 624 Ser Gly
Val Pro Asp Arg Phe Ser Ala Ser Ile Asp Arg Ser Ser Asn 195 200 205
tct gcc tcc ctc acc atc tct gga ctg atg act gag gac gag gct gac 672
Ser Ala Ser Leu Thr Ile Ser Gly Leu Met Thr Glu Asp Glu Ala Asp 210
215 220 tac tac tgt cag tct tat gat agc aac aat cat tgg gtg ttc ggc
gga 720 Tyr Tyr Cys Gln Ser Tyr Asp Ser Asn Asn His Trp Val Phe Gly
Gly 225 230 235 240 ggg acc aag ctg acc gtc cta ggt 744 Gly Thr Lys
Leu Thr Val Leu Gly 245 <210> SEQ ID NO 132 <211>
LENGTH: 735 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(735) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0183 scFv protein <400> SEQUENCE: 132 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg agg gga tcc gat agc agc aac
tgg ttc ttt gac tac tgg ggc cag 336 Ala Arg Gly Ser Asp Ser Ser Asn
Trp Phe Phe Asp Tyr Trp Gly Gln 100 105 110 ggg aca atg gtc acc gtc
tcg agt gga ggc ggc ggt tca ggc gga ggt 384 Gly Thr Met Val Thr Val
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 ggc tct ggc ggt
ggc gga agt gca ctt gat gtt gtg atg act cag tct 432 Gly Ser Gly Gly
Gly Gly Ser Ala Leu Asp Val Val Met Thr Gln Ser 130 135 140 cca gcc
acc ctg tct ttg tct cca ggg gaa aga gcc acc ctc tcc tgc 480 Pro Ala
Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 145 150 155
160 agg gcc agt cag agt gtt agc agc ttc tta gcc tgg tac caa cag aaa
528 Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys
165 170 175 cct ggc cag gct ccc agg ctc ctc atg tat gat gca tcc aac
agg gcc 576 Pro Gly Gln Ala Pro Arg Leu Leu Met Tyr Asp Ala Ser Asn
Arg Ala 180 185 190 act ggc atc cca gcc agg ttc agt ggc agt ggg tct
ggg aca gac ttc 624 Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser
Gly Thr Asp Phe 195 200 205 act ctc acc atc agc agc cta gag cct gaa
gat ttt gca gtt tat tac 672 Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
Asp Phe Ala Val Tyr Tyr 210 215 220 tgt cag cag cgt agc aac tgg ccg
atc acc ttc ggc caa ggg aca cga 720 Cys Gln Gln Arg Ser Asn Trp Pro
Ile Thr Phe Gly Gln Gly Thr Arg 225 230 235 240 ctg gag att aaa cgt
735 Leu Glu Ile Lys Arg 245 <210> SEQ ID NO 133 <211>
LENGTH: 726 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(726) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0193 scFv protein <400> SEQUENCE: 133 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gca aga agg cgg tat gcg ttg gat
tat tgg ggc cgg ggc acc ctg gtc 336 Ala Arg Arg Arg Tyr Ala Leu Asp
Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110 acc gtc tcg agt gga ggc
ggc ggt tca ggc gga ggt ggc tct ggc ggt 384
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115
120 125 ggc gga agt gca ctt tct tct gag ctg act cag gac cct gct gtg
tct 432 Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Ala Val
Ser 130 135 140 gtg gcc ttg gga cag aca gtc agg atc aca tgc cag gga
gac agc ctc 480 Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly
Asp Ser Leu 145 150 155 160 aga aac tat tat cca agc tgg tac cag cag
agc cca gga cag gcc cct 528 Arg Asn Tyr Tyr Pro Ser Trp Tyr Gln Gln
Ser Pro Gly Gln Ala Pro 165 170 175 gta ctt gtc atc tat ggt aaa aac
aag cgg ccc tca ggg atc cca gac 576 Val Leu Val Ile Tyr Gly Lys Asn
Lys Arg Pro Ser Gly Ile Pro Asp 180 185 190 cga ttc tct ggc tcc agc
tca gga aac aca gct tcc ttg acc atc act 624 Arg Phe Ser Gly Ser Ser
Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr 195 200 205 ggg gct cag gcg
gaa gat gag gct gac tat tac tgt aac tcc cgg gac 672 Gly Ala Gln Ala
Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp 210 215 220 agc agt
ggt aac cat cta cta ttc ggc gga ggg acc aag ctg acc gtc 720 Ser Ser
Gly Asn His Leu Leu Phe Gly Gly Gly Thr Lys Leu Thr Val 225 230 235
240 cta ggt 726 Leu Gly <210> SEQ ID NO 134 <211>
LENGTH: 741 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(741) <223> OTHER INFORMATION: Polynucleotide
encoding RGD0195 scFv protein <400> SEQUENCE: 134 gag gtg cag
ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg 48 Glu Val Gln
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 tcc
ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat 96 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc
144 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac
tcc gtg 192 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
Ser Val 50 55 60 aag ggc cgg ttc acc atc tcc aga gac aat tcc aag
aac acg ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac
acg gcc gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aca gat cct tac tat gat agt
agt ggt tat tac ccc ttt agc tac 336 Ala Thr Asp Pro Tyr Tyr Asp Ser
Ser Gly Tyr Tyr Pro Phe Ser Tyr 100 105 110 tgg ggc caa ggg aca atg
gtc acc gtc tcg agt gga ggc ggc ggt tca 384 Trp Gly Gln Gly Thr Met
Val Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125 ggc gga ggt ggc
tct ggc ggt ggc gga agt gca cag tct gtg ctg act 432 Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr 130 135 140 cag cca
ccc tca gtg tca gtg gcc cca gga aag acg gcc aca att acc 480 Gln Pro
Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Thr Ile Thr 145 150 155
160 tgt ggg gga gac ttt gca act aaa aat gtg aat tgg tac caa cgg aag
528 Cys Gly Gly Asp Phe Ala Thr Lys Asn Val Asn Trp Tyr Gln Arg Lys
165 170 175 ccg ggc cag gcc cct gtg acg gtc atc tat tat aat acc gag
cgg ccc 576 Pro Gly Gln Ala Pro Val Thr Val Ile Tyr Tyr Asn Thr Glu
Arg Pro 180 185 190 tca gcg atc cct gag cgc ttc tct ggc tcc aac act
ggg tcc acg gcc 624 Ser Ala Ile Pro Glu Arg Phe Ser Gly Ser Asn Thr
Gly Ser Thr Ala 195 200 205 acc ctg acc atc agc agg gtc gaa gcc ggg
gat gag gcc gac tat tat 672 Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
Asp Glu Ala Asp Tyr Tyr 210 215 220 tgt cag gtg tgg gat agt ttt act
gat cat cgg ctg ttc ggc gga ggg 720 Cys Gln Val Trp Asp Ser Phe Thr
Asp His Arg Leu Phe Gly Gly Gly 225 230 235 240 acc aag ctg act gtc
cta ggt 741 Thr Lys Leu Thr Val Leu Gly 245 <210> SEQ ID NO
135 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 135 caggtgcagc tggtgcagtc tgg 23
<210> SEQ ID NO 136 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 136 caggtcaact taagggagtc tgg
23 <210> SEQ ID NO 137 <211> LENGTH: 23 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 137 gaggtgcagc
tggtggagtc tgg 23 <210> SEQ ID NO 138 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 138
caggtgcagc tgcaggagtc ggg 23 <210> SEQ ID NO 139 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 139 gaggtgcagc tgttgcagtc tgc 23 <210> SEQ ID NO
140 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 140 caggtacagc tgcagcagtc agg 23
<210> SEQ ID NO 141 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 141 tgaggagacg gtgaccaggg tgcc
24 <210> SEQ ID NO 142 <211> LENGTH: 24 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 142 tgaagagacg
gtgaccattg tccc 24 <210> SEQ ID NO 143 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 143
tgaggagacg gtgaccaggg ttcc 24 <210> SEQ ID NO 144 <211>
LENGTH: 24 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 144 tgaggagacg gtgaccgtgg tccc 24 <210> SEQ ID NO
145 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 145
gacatccaga tgacccagtc tcc 23 <210> SEQ ID NO 146 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 146 gatgttgtga tgactcagtc tcc 23 <210> SEQ ID NO
147 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 147 gatattgtga tgactcagtc tcc 23
<210> SEQ ID NO 148 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 148 gaaattgtgt tgacgcagtc tcc
23 <210> SEQ ID NO 149 <211> LENGTH: 23 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 149 gacatcgtga
tgacccagtc tcc 23 <210> SEQ ID NO 150 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 150
gaaacgacac tcacgcagtc tcc 23 <210> SEQ ID NO 151 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 151 gaaattgtgc tgactcagtc tcc 23 <210> SEQ ID NO
152 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 152 cagtctgtgt tgacgcagcc gcc 23
<210> SEQ ID NO 153 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 153 cagtctgccc tgactcagcc tgc
23 <210> SEQ ID NO 154 <211> LENGTH: 23 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 154 tcctatgtgc
tgactcagcc acc 23 <210> SEQ ID NO 155 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 155
tcttctgagc tgactcagga ccc 23 <210> SEQ ID NO 156 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 156 cacgttatac tgactcaacc gcc 23 <210> SEQ ID NO
157 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 157 caggctgtgc tcactcagcc gtc 23
<210> SEQ ID NO 158 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 158 aattttatgc tgactcagcc cca
23 <210> SEQ ID NO 159 <211> LENGTH: 24 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 159 acgtttgatt
tccaccttgg tccc 24 <210> SEQ ID NO 160 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 160
acgtttgatc tccagcttgg tccc 24 <210> SEQ ID NO 161 <211>
LENGTH: 24 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 161 acgtttgata tccactttgg tccc 24 <210> SEQ ID NO
162 <211> LENGTH: 24 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 162 acgtttgatc tccaccttgg tccc 24
<210> SEQ ID NO 163 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 163 acgtttaatc tccagtcgtg tccc
24 <210> SEQ ID NO 164 <211> LENGTH: 23 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 164 cagtctgtgt
tgacgcagcc gcc 23
<210> SEQ ID NO 165 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 165 cagtctgccc tgactcagcc tgc
23 <210> SEQ ID NO 166 <211> LENGTH: 23 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: PCR primer useful for
amplifying VH and VL domains <400> SEQUENCE: 166 tcctatgtgc
tgactcagcc acc 23 <210> SEQ ID NO 167 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR primer
useful for amplifying VH and VL domains <400> SEQUENCE: 167
tcttctgagc tgactcagga ccc 23 <210> SEQ ID NO 168 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
primer useful for amplifying VH and VL domains <400>
SEQUENCE: 168 cacgttatac tgactcaacc gcc 23 <210> SEQ ID NO
169 <211> LENGTH: 23 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR primer useful for amplifying VH and VL
domains <400> SEQUENCE: 169 caggctgtgc tcactcagcc gtc 23
<210> SEQ ID NO 170 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR primer useful for amplifying VH
and VL domains <400> SEQUENCE: 170 aattttatgc tgactcagcc cca
23 <210> SEQ ID NO 171 <211> LENGTH: 1114 <212>
TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE:
171 gcacgaggcc aaacagattt gcagatcaag gagaacccag gagtttcaaa
gaagcgctag 60 taaggtctct gagatccttg cactagctac atcctcaggg
taggaggaag atggcttcca 120 gaagcatgcg gctgctccta ttgctgagct
gcctggccaa aacaggagtc ctgggtgata 180 tcatcatgag acccagctgt
gctcctggat ggttttacca caagtccaat tgctatggtt 240 acttcaggaa
gctgaggaac tggtctgatg ccgagctcga gtgtcagtct tacggaaacg 300
gagcccacct ggcatctatc ctgagtttaa aggaagccag caccatagca gagtacataa
360 gtggctatca gagaagccag ccgatatgga ttggcctgca cgacccacag
aagaggcagc 420 agtggcagtg gattgatggg gccatgtatc tgtacagatc
ctggtctggc aagtccatgg 480 gtgggaacaa gcactgtgct gagatgagct
ccaataacaa ctttttaact tggagcagca 540 acgaatgcaa caagcgccaa
cacttcctgt gcaagtaccg accatagagc aagaatcaag 600 attctgctaa
ctcctgcaca gccccgtcct cttcctttct gctagcctgg ctaaatctgc 660
tcattatttc agaggggaaa cctagcaaac taagagtgat aagggcccta ctacactggc
720 ttttttaggc ttagagacag aaactttagc attggcccag tagtggcttc
tagctctaaa 780 tgtttgcccc gccatccctt tccacagtat ccttcttccc
tcctcccctg tctctggctg 840 tctcgagcag tctagaagag tgcatctcca
gcctatgaaa cagctgggtc tttggccata 900 agaagtaaag atttgaagac
agaaggaaga aactcaggag taagcttcta gaccccttca 960 gcttctacac
ccttctgccc tctctccatt gcctgcaccc caccccagcc actcaactcc 1020
tgcttgtttt tcctttggcc ataggaaggt ttaccagtag aatccttgct aggttgatgt
1080 gggccataca ttcctttaat aaaccattgt gtac 1114 <210> SEQ ID
NO 172 <211> LENGTH: 158 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 172 Met Ala Ser Arg
Ser Met Arg Leu Leu Leu Leu Leu Ser Cys Leu Ala 1 5 10 15 Lys Thr
Gly Val Leu Gly Asp Ile Ile Met Arg Pro Ser Cys Ala Pro 20 25 30
Gly Trp Phe Tyr His Lys Ser Asn Cys Tyr Gly Tyr Phe Arg Lys Leu 35
40 45 Arg Asn Trp Ser Asp Ala Glu Leu Glu Cys Gln Ser Tyr Gly Asn
Gly 50 55 60 Ala His Leu Ala Ser Ile Leu Ser Leu Lys Glu Ala Ser
Thr Ile Ala 65 70 75 80 Glu Tyr Ile Ser Gly Tyr Gln Arg Ser Gln Pro
Ile Trp Ile Gly Leu 85 90 95 His Asp Pro Gln Lys Arg Gln Gln Trp
Gln Trp Ile Asp Gly Ala Met 100 105 110 Tyr Leu Tyr Arg Ser Trp Ser
Gly Lys Ser Met Gly Gly Asn Lys His 115 120 125 Cys Ala Glu Met Ser
Ser Asn Asn Asn Phe Leu Thr Trp Ser Ser Asn 130 135 140 Glu Cys Asn
Lys Arg Gln His Phe Leu Cys Lys Tyr Arg Pro 145 150 155 <210>
SEQ ID NO 173 <211> LENGTH: 137 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <220> FEATURE: <223>
OTHER INFORMATION: human mature J chain <400> SEQUENCE: 173
Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 1 5
10 15 Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu
Asp 20 25 30 Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn
Asn Arg Glu 35 40 45 Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr
Arg Phe Val Tyr His 50 55 60 Leu Ser Asp Leu Cys Lys Lys Cys Asp
Pro Thr Glu Val Glu Leu Asp 65 70 75 80 Asn Gln Ile Val Thr Ala Thr
Gln Ser Asn Ile Cys Asp Glu Asp Ser 85 90 95 Ala Thr Glu Thr Cys
Tyr Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 100 105 110 Val Val Pro
Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 115 120 125 Leu
Thr Pro Asp Ala Cys Tyr Pro Asp 130 135 <210> SEQ ID NO 174
<211> LENGTH: 137 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Mutant form of human mature J chain with C134S
mutation compared to wild type Mature form of human J chain (SEQ ID
NO:173) <400> SEQUENCE: 174 Gln Glu Asp Glu Arg Ile Val Leu
Val Asp Asn Lys Cys Lys Cys Ala 1 5 10 15 Arg Ile Thr Ser Arg Ile
Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 20 25 30 Ile Val Glu Arg
Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu 35 40 45 Asn Ile
Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His 50 55 60
Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 65
70 75 80 Asn Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu
Asp Ser 85 90 95 Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg Asn Lys
Cys Tyr Thr Ala 100 105 110 Val Val Pro Leu Val Tyr Gly Gly Glu Thr
Lys Met Val Glu Thr Ala 115 120 125 Leu Thr Pro Asp Ala Ser Tyr Pro
Asp 130 135 <210> SEQ ID NO 175 <211> LENGTH: 112
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Mutant form of
human mature J chain with amino acids 113-137 deleted compared to
wild type Mature form of human J chain (SEQ ID NO:173) <400>
SEQUENCE: 175
Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 1 5
10 15 Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu
Asp 20 25 30 Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn
Asn Arg Glu 35 40 45 Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr
Arg Phe Val Tyr His 50 55 60 Leu Ser Asp Leu Cys Lys Lys Cys Asp
Pro Thr Glu Val Glu Leu Asp 65 70 75 80 Asn Gln Ile Val Thr Ala Thr
Gln Ser Asn Ile Cys Asp Glu Asp Ser 85 90 95 Ala Thr Glu Thr Cys
Tyr Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 100 105 110 <210>
SEQ ID NO 176 <211> LENGTH: 137 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Mutant form of human mature J chain
with C109S and C134S mutation compared to wild type mature form of
human J chain (SEQ ID NO:173) <400> SEQUENCE: 176 Gln Glu Asp
Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 1 5 10 15 Arg
Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 20 25
30 Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu
35 40 45 Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val
Tyr His 50 55 60 Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu
Val Glu Leu Asp 65 70 75 80 Asn Gln Ile Val Thr Ala Thr Gln Ser Asn
Ile Cys Asp Glu Asp Ser 85 90 95 Ala Thr Glu Thr Cys Tyr Thr Tyr
Asp Arg Asn Lys Ser Tyr Thr Ala 100 105 110 Val Val Pro Leu Val Tyr
Gly Gly Glu Thr Lys Met Val Glu Thr Ala 115 120 125 Leu Thr Pro Asp
Ala Ser Tyr Pro Asp 130 135
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