U.S. patent application number 12/758672 was filed with the patent office on 2010-08-05 for streptococcus pneumoniae antigens and vaccines. This patent application is currently assigned to Human Genome Sciences, Inc.. Invention is credited to Steven C. Barash, Gil H. Choi, Patrick J. Dillon, Brian Dougherty, Michael R. Fannon, Charles A. Kunsch, Craig A. Rosen.
Application Number | 20100196410 12/758672 |
Document ID | / |
Family ID | 21851789 |
Filed Date | 2010-08-05 |
United States Patent Application | 20100196410 |
Kind Code | A1 |
Choi; Gil H. ; et al. | August 5, 2010 |
The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
Inventors: | Choi; Gil H.; (Rockville, MD) ; Kunsch; Charles A.; (Norcross, GA) ; Barash; Steven C.; (Rockville, MD) ; Dillon; Patrick J.; (Carlsbad, CA) ; Dougherty; Brian; (Killingworth, CT) ; Fannon; Michael R.; (Silver Spring, MD) ; Rosen; Craig A.; (Laytonsville, MD) |
Correspondence Address: |
HUMAN GENOME SCIENCES INC.;INTELLECTUAL PROPERTY DEPT. 14200 SHADY GROVE ROAD ROCKVILLE MD 20850 US |
Assignee: | Human Genome Sciences, Inc. Rockville MD |
Family ID: | 21851789 |
Appl. No.: | 12/758672 |
Filed: | April 12, 2010 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
11106649 | Apr 15, 2005 | |||
12758672 | ||||
08961083 | Oct 30, 1997 | 7056510 | ||
11106649 | ||||
09536784 | Mar 28, 2000 | 6573082 | ||
09765271 | Jan 22, 2001 | |||
08961083 | Oct 30, 1997 | 7056510 | ||
09536784 | ||||
08961083 | Oct 30, 1997 | 7056510 | ||
09765271 | ||||
60029960 | Oct 31, 1996 | |||
60029960 | Oct 31, 1996 | |||
60029960 | Oct 31, 1996 | |||
Current U.S. Class: | 424/190.1 ; 435/243; 435/320.1; 435/440; 435/6.15; 435/69.1; 530/350; 530/389.5; 536/23.7 |
Current CPC Class: | A61K 39/00 20130101; C07K 14/3156 20130101; A61P 31/04 20180101; C07K 14/315 20130101; A61K 38/00 20130101; A61P 37/04 20180101 |
Class at Publication: | 424/190.1 ; 536/23.7; 530/350; 530/389.5; 435/320.1; 435/440; 435/243; 435/69.1; 435/6 |
International Class: | A61K 39/09 20060101 A61K039/09; C07H 21/04 20060101 C07H021/04; C07K 14/315 20060101 C07K014/315; C07K 16/12 20060101 C07K016/12; A61P 31/04 20060101 A61P031/04; C12N 15/63 20060101 C12N015/63; C12N 15/00 20060101 C12N015/00; C12N 1/00 20060101 C12N001/00; C12P 21/00 20060101 C12P021/00; C12Q 1/68 20060101 C12Q001/68 |
Sequence CWU 1
1
45411999DNAStreptococcus pneumoniae 1taaaatctac gacaataaaa
atcaactcat tgctgacttg ggttctgaac gccgcgtcaa 60tgcccaagct aatgatattc
ccacagattt ggttaaggca atcgtttcta tcgaagacca 120tcgcttcttc
gaccacaggg ggattgatac catccgtatc ctgggagctt tcttgcgcaa
180tctgcaaagc aattccctcc aaggtggatc aactctcacc caacagttga
ttaagttgac 240ttacttttca acttcgactt ccgaccagac tatttctcgt
aaggctcagg aagcttggtt 300agcgattcag ttagaacaaa aagcaaccaa
gcaagaaatc ttgacctact atataaataa 360ggtctacatg tctaatggga
actatggaat gcagacagca gctcaaaact actatggtaa 420agacctcaat
aatttaagtt tacctcagtt agccttgctg gctggaatgc ctcaggcacc
480aaaccaatat gacccctatt cacatccaga agcagcccaa gaccgccgaa
acttggtctt 540atctgaaatg aaaaatcaag gctacatctc tgctgaacag
tatgagaaag cagtcaatac 600accaattact gatggactac aaagtctcaa
atcagcaagt aattaccctg cttacatgga 660taattacctc aaggaagtca
tcaatcaagt tgaagaagaa acaggctata acctactcac 720aactgggatg
gatgtctaca caaatgtaga ccaagaagct caaaaacatc tgtgggatat
780ttacaataca gacgaatacg ttgcctatcc agacgatgaa ttgcaagtcg
cttctaccat 840tgttgatgtt tctaacggta aagtcattgc ccagctagga
gcacgccatc agtcaagtaa 900tgtttccttc ggaattaacc aagcagtaga
aacaaaccgc gactggggat caactatgaa 960accgatcaca gactatgctc
ctgccttgga gtacggtgtc tacgattcaa ctgctactat 1020cgttcacgat
gagccctata actaccctgg gacaaatact cctgtttata actgggatag
1080gggctacttt ggcaacatca ccttgcaata cgccctgcaa caatcgcgaa
acgtcccagc 1140cgtggaaact ctaaacaagg tcggactcaa ccgcgccaag
actttcctaa atggtctagg 1200aatcgactac ccaagtattc actactcaaa
tgccatttca agtaacacaa ccgaatcaga 1260caaaaaatat ggagcaagta
gtgaaaagat ggctgctgct tacgctgcct ttgcaaatgg 1320tggaacttac
tataaaccaa tgtatatcca taaagtcgtc tttagtgatg ggagtgaaaa
1380agagttctct aatgtcggaa ctcgtgccat gaaggaaacg acagcctata
tgatgaccga 1440catgatgaaa acagtcttga cttatggaac tggacgaaat
gcctatcttg cttggctccc 1500tcaggctggt aaaacaggaa cctctaacta
tacagacgag gaaattgaaa accacatcaa 1560gacctctcaa tttgtagcac
ctgatgaact atttgctggc tatacgcgta aatattcaat 1620ggctgtatgg
acaggctatt ctaaccgtct gacaccactt gtaggcaatg gccttacggt
1680cgctgccaaa gtttaccgct ctatgatgac ctacctgtct gaaggaagca
atccagaaga 1740ttggaatata ccagaggggc tctacagaaa tggagaattc
gtatttaaaa atggtgctcg 1800ttctacgtgg aactcacctg ctccacaaca
acccccatca actgaaagtt caagctcatc 1860atcagatagt tcaacttcac
agtctagctc aaccactcca agcacaaata atagtacgac 1920taccaatcct
aacaataata cgcaacaatc aaatacaacc cctgatcaac aaaatcagaa
1980tcctcaacca gcacaacca 19992666PRTStreptococcus pneumoniae 2Lys
Ile Tyr Asp Asn Lys Asn Gln Leu Ile Ala Asp Leu Gly Ser Glu1 5 10
15Arg Arg Val Asn Ala Gln Ala Asn Asp Ile Pro Thr Asp Leu Val Lys
20 25 30Ala Ile Val Ser Ile Glu Asp His Arg Phe Phe Asp His Arg Gly
Ile 35 40 45Asp Thr Ile Arg Ile Leu Gly Ala Phe Leu Arg Asn Leu Gln
Ser Asn 50 55 60Ser Leu Gln Gly Gly Ser Thr Leu Thr Gln Gln Leu Ile
Lys Leu Thr65 70 75 80Tyr Phe Ser Thr Ser Thr Ser Asp Gln Thr Ile
Ser Arg Lys Ala Gln 85 90 95Glu Ala Trp Leu Ala Ile Gln Leu Glu Gln
Lys Ala Thr Lys Gln Glu 100 105 110Ile Leu Thr Tyr Tyr Ile Asn Lys
Val Tyr Met Ser Asn Gly Asn Tyr 115 120 125Gly Met Gln Thr Ala Ala
Gln Asn Tyr Tyr Gly Lys Asp Leu Asn Asn 130 135 140Leu Ser Leu Pro
Gln Leu Ala Leu Leu Ala Gly Met Pro Gln Ala Pro145 150 155 160Asn
Gln Tyr Asp Pro Tyr Ser His Pro Glu Ala Ala Gln Asp Arg Arg 165 170
175Asn Leu Val Leu Ser Glu Met Lys Asn Gln Gly Tyr Ile Ser Ala Glu
180 185 190Gln Tyr Glu Lys Ala Val Asn Thr Pro Ile Thr Asp Gly Leu
Gln Ser 195 200 205Leu Lys Ser Ala Ser Asn Tyr Pro Ala Tyr Met Asp
Asn Tyr Leu Lys 210 215 220Glu Val Ile Asn Gln Val Glu Glu Glu Thr
Gly Tyr Asn Leu Leu Thr225 230 235 240Thr Gly Met Asp Val Tyr Thr
Asn Val Asp Gln Glu Ala Gln Lys His 245 250 255Leu Trp Asp Ile Tyr
Asn Thr Asp Glu Tyr Val Ala Tyr Pro Asp Asp 260 265 270Glu Leu Gln
Val Ala Ser Thr Ile Val Asp Val Ser Asn Gly Lys Val 275 280 285Ile
Ala Gln Leu Gly Ala Arg His Gln Ser Ser Asn Val Ser Phe Gly 290 295
300Ile Asn Gln Ala Val Glu Thr Asn Arg Asp Trp Gly Ser Thr Met
Lys305 310 315 320Pro Ile Thr Asp Tyr Ala Pro Ala Leu Glu Tyr Gly
Val Tyr Asp Ser 325 330 335Thr Ala Thr Ile Val His Asp Glu Pro Tyr
Asn Tyr Pro Gly Thr Asn 340 345 350Thr Pro Val Tyr Asn Trp Asp Arg
Gly Tyr Phe Gly Asn Ile Thr Leu 355 360 365Gln Tyr Ala Leu Gln Gln
Ser Arg Asn Val Pro Ala Val Glu Thr Leu 370 375 380Asn Lys Val Gly
Leu Asn Arg Ala Lys Thr Phe Leu Asn Gly Leu Gly385 390 395 400Ile
Asp Tyr Pro Ser Ile His Tyr Ser Asn Ala Ile Ser Ser Asn Thr 405 410
415Thr Glu Ser Asp Lys Lys Tyr Gly Ala Ser Ser Glu Lys Met Ala Ala
420 425 430Ala Tyr Ala Ala Phe Ala Asn Gly Gly Thr Tyr Tyr Lys Pro
Met Tyr 435 440 445Ile His Lys Val Val Phe Ser Asp Gly Ser Glu Lys
Glu Phe Ser Asn 450 455 460Val Gly Thr Arg Ala Met Lys Glu Thr Thr
Ala Tyr Met Met Thr Asp465 470 475 480Met Met Lys Thr Val Leu Thr
Tyr Gly Thr Gly Arg Asn Ala Tyr Leu 485 490 495Ala Trp Leu Pro Gln
Ala Gly Lys Thr Gly Thr Ser Asn Tyr Thr Asp 500 505 510Glu Glu Ile
Glu Asn His Ile Lys Thr Ser Gln Phe Val Ala Pro Asp 515 520 525Glu
Leu Phe Ala Gly Tyr Thr Arg Lys Tyr Ser Met Ala Val Trp Thr 530 535
540Gly Tyr Ser Asn Arg Leu Thr Pro Leu Val Gly Asn Gly Leu Thr
Val545 550 555 560Ala Ala Lys Val Tyr Arg Ser Met Met Thr Tyr Leu
Ser Glu Gly Ser 565 570 575Asn Pro Glu Asp Trp Asn Ile Pro Glu Gly
Leu Tyr Arg Asn Gly Glu 580 585 590Phe Val Phe Lys Asn Gly Ala Arg
Ser Thr Trp Asn Ser Pro Ala Pro 595 600 605Gln Gln Pro Pro Ser Thr
Glu Ser Ser Ser Ser Ser Ser Asp Ser Ser 610 615 620Thr Ser Gln Ser
Ser Ser Thr Thr Pro Ser Thr Asn Asn Ser Thr Thr625 630 635 640Thr
Asn Pro Asn Asn Asn Thr Gln Gln Ser Asn Thr Thr Pro Asp Gln 645 650
655Gln Asn Gln Asn Pro Gln Pro Ala Gln Pro 660
66531714DNAStreptococcus pneumoniae 3aaattacaat acggactatg
aattgacctc tggagaaaaa ttacctcttc ctaaagagat 60ttcaggttac acttatattg
gatatatcaa agagggaaaa acgacttctg agtctgaagt 120aagtaatcaa
aagagttcag ttgccactcc tacaaaacaa caaaaggtgg attataatgt
180tacaccgaat tttgtagacc atccatcaac agtacaagct attcaggaac
aaacacctgt 240ttcttcaact aagccgacag aagttcaagt agttgaaaaa
cctttctcta ctgaattaat 300caatccaaga aaagaagaga aacaatcttc
agattctcaa gaacaattag ccgaacataa 360gaatctagaa acgaagaaag
aggagaagat ttctccaaaa gaaaagactg gggtaaatac 420attaaatcca
caggatgaag ttttatcagg tcaattgaac aaacctgaac tcttatatcg
480tgaggaaact atggagacaa aaatagattt tcaagaagaa attcaagaaa
atcctgattt 540agctgaagga actgtaagag taaaacaaga aggtaaatta
ggtaagaaag ttgaaatcgt 600cagaatattc tctgtaaaca aggaagaagt
ttcgcgagaa attgtttcaa cttcaacgac 660tgcgcctagt ccaagaatag
tcgaaaaagg tactaaaaaa actcaagtta taaaggaaca 720acctgagact
ggtgtagaac ataaggacgt acagtctgga gctattgttg aacccgcaat
780tcagcctgag ttgcccgaag ctgtagtaag tgacaaaggc gaaccagaag
ttcaacctac 840attacccgaa gcagttgtga ccgacaaagg tgagactgag
gttcaaccag agtcgccaga 900tactgtggta agtgataaag gtgaaccaga
gcaggtagca ccgcttccag aatataaggg 960taatattgag caagtaaaac
ctgaaactcc ggttgagaag accaaagaac aaggtccaga 1020aaaaactgaa
gaagttccag taaaaccaac agaagaaaca ccagtaaatc caaatgaagg
1080tactacagaa ggaacctcaa ttcaagaagc agaaaatcca gttcaacctg
cagaagaatc 1140aacaacgaat tcagagaaag tatcaccaga tacatctagc
aaaaatactg gggaagtgtc 1200cagtaatcct agtgattcga caacctcagt
tggagaatca aataaaccag aacataatga 1260ctctaaaaat gaaaattcag
aaaaaactgt agaagaagtt ccagtaaatc caaatgaagg 1320cacagtagaa
ggtacctcaa atcaagaaac agaaaaacca gttcaacctg cagaagaaac
1380acaaacaaac tctgggaaaa tagctaacga aaatactgga gaagtatcca
ataaacctag 1440tgattcaaaa ccaccagttg aagaatcaaa tcaaccagaa
aaaaacggaa ctgcaacaaa 1500accagaaaat tcaggtaata caacatcaga
gaatggacaa acagaaccag aaccatcaaa 1560cggaaattca actgaggatg
tttcaaccga atcaaacaca tccaattcaa atggaaacga 1620agaaattaaa
caagaaaatg aactagaccc tgataaaaag gtagaagaac cagagaaaac
1680acttgaatta agaaatgttt ccgacctaga gtta 17144571PRTStreptococcus
pneumoniae 4Asn Tyr Asn Thr Asp Tyr Glu Leu Thr Ser Gly Glu Lys Leu
Pro Leu1 5 10 15Pro Lys Glu Ile Ser Gly Tyr Thr Tyr Ile Gly Tyr Ile
Lys Glu Gly 20 25 30Lys Thr Thr Ser Glu Ser Glu Val Ser Asn Gln Lys
Ser Ser Val Ala 35 40 45Thr Pro Thr Lys Gln Gln Lys Val Asp Tyr Asn
Val Thr Pro Asn Phe 50 55 60Val Asp His Pro Ser Thr Val Gln Ala Ile
Gln Glu Gln Thr Pro Val65 70 75 80Ser Ser Thr Lys Pro Thr Glu Val
Gln Val Val Glu Lys Pro Phe Ser 85 90 95Thr Glu Leu Ile Asn Pro Arg
Lys Glu Glu Lys Gln Ser Ser Asp Ser 100 105 110Gln Glu Gln Leu Ala
Glu His Lys Asn Leu Glu Thr Lys Lys Glu Glu 115 120 125Lys Ile Ser
Pro Lys Glu Lys Thr Gly Val Asn Thr Leu Asn Pro Gln 130 135 140Asp
Glu Val Leu Ser Gly Gln Leu Asn Lys Pro Glu Leu Leu Tyr Arg145 150
155 160Glu Glu Thr Met Glu Thr Lys Ile Asp Phe Gln Glu Glu Ile Gln
Glu 165 170 175Asn Pro Asp Leu Ala Glu Gly Thr Val Arg Val Lys Gln
Glu Gly Lys 180 185 190Leu Gly Lys Lys Val Glu Ile Val Arg Ile Phe
Ser Val Asn Lys Glu 195 200 205Glu Val Ser Arg Glu Ile Val Ser Thr
Ser Thr Thr Ala Pro Ser Pro 210 215 220Arg Ile Val Glu Lys Gly Thr
Lys Lys Thr Gln Val Ile Lys Glu Gln225 230 235 240Pro Glu Thr Gly
Val Glu His Lys Asp Val Gln Ser Gly Ala Ile Val 245 250 255Glu Pro
Ala Ile Gln Pro Glu Leu Pro Glu Ala Val Val Ser Asp Lys 260 265
270Gly Glu Pro Glu Val Gln Pro Thr Leu Pro Glu Ala Val Val Thr Asp
275 280 285Lys Gly Glu Thr Glu Val Gln Pro Glu Ser Pro Asp Thr Val
Val Ser 290 295 300Asp Lys Gly Glu Pro Glu Gln Val Ala Pro Leu Pro
Glu Tyr Lys Gly305 310 315 320Asn Ile Glu Gln Val Lys Pro Glu Thr
Pro Val Glu Lys Thr Lys Glu 325 330 335Gln Gly Pro Glu Lys Thr Glu
Glu Val Pro Val Lys Pro Thr Glu Glu 340 345 350Thr Pro Val Asn Pro
Asn Glu Gly Thr Thr Glu Gly Thr Ser Ile Gln 355 360 365Glu Ala Glu
Asn Pro Val Gln Pro Ala Glu Glu Ser Thr Thr Asn Ser 370 375 380Glu
Lys Val Ser Pro Asp Thr Ser Ser Lys Asn Thr Gly Glu Val Ser385 390
395 400Ser Asn Pro Ser Asp Ser Thr Thr Ser Val Gly Glu Ser Asn Lys
Pro 405 410 415Glu His Asn Asp Ser Lys Asn Glu Asn Ser Glu Lys Thr
Val Glu Glu 420 425 430Val Pro Val Asn Pro Asn Glu Gly Thr Val Glu
Gly Thr Ser Asn Gln 435 440 445Glu Thr Glu Lys Pro Val Gln Pro Ala
Glu Glu Thr Gln Thr Asn Ser 450 455 460Gly Lys Ile Ala Asn Glu Asn
Thr Gly Glu Val Ser Asn Lys Pro Ser465 470 475 480Asp Ser Lys Pro
Pro Val Glu Glu Ser Asn Gln Pro Glu Lys Asn Gly 485 490 495Thr Ala
Thr Lys Pro Glu Asn Ser Gly Asn Thr Thr Ser Glu Asn Gly 500 505
510Gln Thr Glu Pro Glu Pro Ser Asn Gly Asn Ser Thr Glu Asp Val Ser
515 520 525Thr Glu Ser Asn Thr Ser Asn Ser Asn Gly Asn Glu Glu Ile
Lys Gln 530 535 540Glu Asn Glu Leu Asp Pro Asp Lys Lys Val Glu Glu
Pro Glu Lys Thr545 550 555 560Leu Glu Leu Arg Asn Val Ser Asp Leu
Glu Leu 565 5705748DNAStreptococcus pneumoniae 5tgagaatcaa
gctacaccca aagagactag cgctcaaaag acaatcgtcc ttgctacagc 60tggcgacgtg
ccaccatttg actacgaaga caagggcaat ctgacaggct ttgatatcga
120agttttaaag gcagtagatg aaaaactcag cgactacgag attcaattcc
aaagaaccgc 180ctgggagagc atcttcccag gacttgattc tggtcactat
caggctgcgg ccaataactt 240gagttacaca aaagagcgtg ctgaaaaata
cctttactcg cttccaattt ccaacaatcc 300cctcgtcctt gtcagcaaca
agaaaaatcc tttgacttct cttgaccaga tcgctggtaa 360aacaacacaa
gaggataccg gaacttctaa cgctcaattc atcaataact ggaatcagaa
420acacactgat aatcccgcta caattaattt ttctggtgag gatattggta
aacgaatcct 480agaccttgct aacggagagt ttgatttcct agtttttgac
aaggtatccg ttcaaaagat 540tatcaaggac cgtggtttag acctctcagt
cgttgattta ccttctgcag atagccccag 600caattatatc attttctcaa
gcgaccaaaa agagtttaaa gagcaatttg ataaagcgct 660caaagaactc
tatcaagacg gaacccttga aaaactcagc aatacctatc taggtggttc
720ttacctccca gatcaatctc agttacaa 7486249PRTStreptococcus
pneumoniae 6Glu Asn Gln Ala Thr Pro Lys Glu Thr Ser Ala Gln Lys Thr
Ile Val1 5 10 15Leu Ala Thr Ala Gly Asp Val Pro Pro Phe Asp Tyr Glu
Asp Lys Gly 20 25 30Asn Leu Thr Gly Phe Asp Ile Glu Val Leu Lys Ala
Val Asp Glu Lys 35 40 45Leu Ser Asp Tyr Glu Ile Gln Phe Gln Arg Thr
Ala Trp Glu Ser Ile 50 55 60Phe Pro Gly Leu Asp Ser Gly His Tyr Gln
Ala Ala Ala Asn Asn Leu65 70 75 80Ser Tyr Thr Lys Glu Arg Ala Glu
Lys Tyr Leu Tyr Ser Leu Pro Ile 85 90 95Ser Asn Asn Pro Leu Val Leu
Val Ser Asn Lys Lys Asn Pro Leu Thr 100 105 110Ser Leu Asp Gln Ile
Ala Gly Lys Thr Thr Gln Glu Asp Thr Gly Thr 115 120 125Ser Asn Ala
Gln Phe Ile Asn Asn Trp Asn Gln Lys His Thr Asp Asn 130 135 140Pro
Ala Thr Ile Asn Phe Ser Gly Glu Asp Ile Gly Lys Arg Ile Leu145 150
155 160Asp Leu Ala Asn Gly Glu Phe Asp Phe Leu Val Phe Asp Lys Val
Ser 165 170 175Val Gln Lys Ile Ile Lys Asp Arg Gly Leu Asp Leu Ser
Val Val Asp 180 185 190Leu Pro Ser Ala Asp Ser Pro Ser Asn Tyr Ile
Ile Phe Ser Ser Asp 195 200 205Gln Lys Glu Phe Lys Glu Gln Phe Asp
Lys Ala Leu Lys Glu Leu Tyr 210 215 220Gln Asp Gly Thr Leu Glu Lys
Leu Ser Asn Thr Tyr Leu Gly Gly Ser225 230 235 240Tyr Leu Pro Asp
Gln Ser Gln Leu Gln 2457985DNAStreptococcus pneumoniae 7tggtaaccgc
tcttctcgta acgcagcttc atcttctgat gtgaagacaa aagcagcaat 60cgtcactgat
actggtggtg ttgatgacaa atcattcaac caatcagctt gggaaggttt
120gcaggcttgg ggtaaagaac acaatctttc aaaagataac ggtttcactt
acttccaatc 180aacaagtgaa gctgactacg ctaacaactt gcaacaagcg
gctggaagtt acaacctaat 240cttcggtgtt ggttttgccc ttaataatgc
agttaaagat gcagcaaaag aacacactga 300cttgaactat gtcttgattg
atgatgtgat taaagaccaa aagaatgttg cgagcgtaac 360tttcgctgat
aatgagtcag gttaccttgc aggtgtggct gcagcaaaaa caactaagac
420aaaacaagtt ggttttgtag gtggtatcga atctgaagtt atctctcgtt
ttgaagcagg 480attcaaggct ggtgttgcgt cagtagaccc atctatcaaa
gtccaagttg actacgctgg 540ttcatttggt gatgcggcta aaggtaaaac
aattgcagcc gcacaatacg cagccggtgc 600agatattgtt taccaagtag
ctggtggtac aggtgcaggt gtctttgcag aggcaaaatc 660tctcaacgaa
agccgtcctg aaaatgaaaa agtttgggtt atcggtgttg atcgtgacca
720agaagcagaa ggtaaataca cttctaaaga tggcaaagaa tcaaactttg
ttcttgtatc 780tactttgaaa caagttggta caactgtaaa agatatttct
aacaaggcag aaagaggaga 840attccctggc ggtcaagtga tcgtttactc
attgaaggat aaaggggttg acttggcagt 900aacaaacctt tcagaagaag
gtaaaaaagc tgtcgaagat gcaaaagcta aaatccttga 960tggaagcgta
aaagttcctg aaaaa 9858328PRTStreptococcus pneumoniae 8Gly Asn Arg
Ser Ser Arg Asn Ala Ala Ser Ser Ser Asp Val Lys Thr1 5 10 15Lys Ala
Ala Ile Val Thr Asp Thr Gly Gly Val Asp Asp Lys Ser Phe 20 25 30Asn
Gln Ser Ala
Trp Glu Gly Leu Gln Ala Trp Gly Lys Glu His Asn 35 40 45Leu Ser Lys
Asp Asn Gly Phe Thr Tyr Phe Gln Ser Thr Ser Glu Ala 50 55 60Asp Tyr
Ala Asn Asn Leu Gln Gln Ala Ala Gly Ser Tyr Asn Leu Ile65 70 75
80Phe Gly Val Gly Phe Ala Leu Asn Asn Ala Val Lys Asp Ala Ala Lys
85 90 95Glu His Thr Asp Leu Asn Tyr Val Leu Ile Asp Asp Val Ile Lys
Asp 100 105 110Gln Lys Asn Val Ala Ser Val Thr Phe Ala Asp Asn Glu
Ser Gly Tyr 115 120 125Leu Ala Gly Val Ala Ala Ala Lys Thr Thr Lys
Thr Lys Gln Val Gly 130 135 140Phe Val Gly Gly Ile Glu Ser Glu Val
Ile Ser Arg Phe Glu Ala Gly145 150 155 160Phe Lys Ala Gly Val Ala
Ser Val Asp Pro Ser Ile Lys Val Gln Val 165 170 175Asp Tyr Ala Gly
Ser Phe Gly Asp Ala Ala Lys Gly Lys Thr Ile Ala 180 185 190Ala Ala
Gln Tyr Ala Ala Gly Ala Asp Ile Val Tyr Gln Val Ala Gly 195 200
205Gly Thr Gly Ala Gly Val Phe Ala Glu Ala Lys Ser Leu Asn Glu Ser
210 215 220Arg Pro Glu Asn Glu Lys Val Trp Val Ile Gly Val Asp Arg
Asp Gln225 230 235 240Glu Ala Glu Gly Lys Tyr Thr Ser Lys Asp Gly
Lys Glu Ser Asn Phe 245 250 255Val Leu Val Ser Thr Leu Lys Gln Val
Gly Thr Thr Val Lys Asp Ile 260 265 270Ser Asn Lys Ala Glu Arg Gly
Glu Phe Pro Gly Gly Gln Val Ile Val 275 280 285Tyr Ser Leu Lys Asp
Lys Gly Val Asp Leu Ala Val Thr Asn Leu Ser 290 295 300Glu Glu Gly
Lys Lys Ala Val Glu Asp Ala Lys Ala Lys Ile Leu Asp305 310 315
320Gly Ser Val Lys Val Pro Glu Lys 32591404DNAStreptococcus
pneumoniaemisc_feature(871)..(871)n is a, c, g, or t 9tgtggaaatt
tgacaggtaa cagcaaaaaa gctgctgatt caggtgacaa acctgttatc 60aaaatgtacc
aaatcggtga caaaccagac aacttggatg aattgttagc aaatgccaac
120aaaatcattg aagaaaaagt tggtgccaaa ttggatatcc aataccttgg
ctggggtgac 180tatggtaaga aaatgtcagt tatcacatca tctggtgaaa
actatgatat tgcctttgca 240gataactata ttgtaaatgc tcaaaaaggt
gcttacgctg acttgacaga attgtacaaa 300aaagaaggta aagaccttta
caaagcactt gacccagctt acatcaaggg taatactgta 360aatggtaaga
tttacgctgt tccagttgca gccaacgttg catcatctca aaactttgcc
420ttcaacggaa ctctccttgc taaatatggt atcgatattt caggtgttac
ttcttacgaa 480actcttgagc cagtcttgaa acaaatcaaa gaaaaagctc
cagacgtagt accatttgct 540attggtaaag ttttcatccc atctgataat
tttgactacc cagtagcaaa cggtcttcca 600ttcgttatcg accttgaagg
cgatactact aaagttgtaa accgttacga agtgcctcgt 660ttcaaagaac
acttgaagac tcttcacaaa ttctatgaag ctggctacat tccaaaagac
720gtcgcaacaa gcgatacttc ctttgacctt caacaagata cttggttcgt
tcgtgaagaa 780acagtaggac cagctgacta cggtaacagc ttgctttcac
gtgttgccaa caaagatatc 840caaatcaaac caattactaa cttcatcaag
naaaaccaaa caacacaagt tgctaacttt 900gtcatctcaa acaactctaa
gaacaaagaa aaatcaatgg aaatcttgaa cctcttgaat 960acgaacccag
aactcttgaa cggtcttgtt tacggtccag aaggcaagaa ctgggaaaaa
1020attgaaggta aagaaaaccg tgttcgcgtt cttgatggct acaaaggaaa
cactcacatg 1080ggtggatgga acactggtaa caactggatc ctttacatca
acgaaaacgt tacagaccaa 1140caaatcgaaa attctaagaa agaattggca
gaagctaaag aatctccagc gcttggattt 1200atcttcaata ctgacaatgt
gaaatctgaa atctcagcta ttgctaacac aatgcaacaa 1260tttgatacag
ctatcaacac tggtactgta gacccagata aagcgattcc agaattgatg
1320gaaaaattga aatctgaagg tgcctacgaa aaagtattga acgaaatgca
aaaacaatac 1380gatgaattct tgaaaaacaa aaaa 140410468PRTStreptococcus
pneumoniaeSITE(291)..(291)Xaa can be any naturally occurring amino
acid 10Cys Gly Asn Leu Thr Gly Asn Ser Lys Lys Ala Ala Asp Ser Gly
Asp1 5 10 15Lys Pro Val Ile Lys Met Tyr Gln Ile Gly Asp Lys Pro Asp
Asn Leu 20 25 30Asp Glu Leu Leu Ala Asn Ala Asn Lys Ile Ile Glu Glu
Lys Val Gly 35 40 45Ala Lys Leu Asp Ile Gln Tyr Leu Gly Trp Gly Asp
Tyr Gly Lys Lys 50 55 60Met Ser Val Ile Thr Ser Ser Gly Glu Asn Tyr
Asp Ile Ala Phe Ala65 70 75 80Asp Asn Tyr Ile Val Asn Ala Gln Lys
Gly Ala Tyr Ala Asp Leu Thr 85 90 95Glu Leu Tyr Lys Lys Glu Gly Lys
Asp Leu Tyr Lys Ala Leu Asp Pro 100 105 110Ala Tyr Ile Lys Gly Asn
Thr Val Asn Gly Lys Ile Tyr Ala Val Pro 115 120 125Val Ala Ala Asn
Val Ala Ser Ser Gln Asn Phe Ala Phe Asn Gly Thr 130 135 140Leu Leu
Ala Lys Tyr Gly Ile Asp Ile Ser Gly Val Thr Ser Tyr Glu145 150 155
160Thr Leu Glu Pro Val Leu Lys Gln Ile Lys Glu Lys Ala Pro Asp Val
165 170 175Val Pro Phe Ala Ile Gly Lys Val Phe Ile Pro Ser Asp Asn
Phe Asp 180 185 190Tyr Pro Val Ala Asn Gly Leu Pro Phe Val Ile Asp
Leu Glu Gly Asp 195 200 205Thr Thr Lys Val Val Asn Arg Tyr Glu Val
Pro Arg Phe Lys Glu His 210 215 220Leu Lys Thr Leu His Lys Phe Tyr
Glu Ala Gly Tyr Ile Pro Lys Asp225 230 235 240Val Ala Thr Ser Asp
Thr Ser Phe Asp Leu Gln Gln Asp Thr Trp Phe 245 250 255Val Arg Glu
Glu Thr Val Gly Pro Ala Asp Tyr Gly Asn Ser Leu Leu 260 265 270Ser
Arg Val Ala Asn Lys Asp Ile Gln Ile Lys Pro Ile Thr Asn Phe 275 280
285Ile Lys Xaa Asn Gln Thr Thr Gln Val Ala Asn Phe Val Ile Ser Asn
290 295 300Asn Ser Lys Asn Lys Glu Lys Ser Met Glu Ile Leu Asn Leu
Leu Asn305 310 315 320Thr Asn Pro Glu Leu Leu Asn Gly Leu Val Tyr
Gly Pro Glu Gly Lys 325 330 335Asn Trp Glu Lys Ile Glu Gly Lys Glu
Asn Arg Val Arg Val Leu Asp 340 345 350Gly Tyr Lys Gly Asn Thr His
Met Gly Gly Trp Asn Thr Gly Asn Asn 355 360 365Trp Ile Leu Tyr Ile
Asn Glu Asn Val Thr Asp Gln Gln Ile Glu Asn 370 375 380Ser Lys Lys
Glu Leu Ala Glu Ala Lys Glu Ser Pro Ala Leu Gly Phe385 390 395
400Ile Phe Asn Thr Asp Asn Val Lys Ser Glu Ile Ser Ala Ile Ala Asn
405 410 415Thr Met Gln Gln Phe Asp Thr Ala Ile Asn Thr Gly Thr Val
Asp Pro 420 425 430Asp Lys Ala Ile Pro Glu Leu Met Glu Lys Leu Lys
Ser Glu Gly Ala 435 440 445Tyr Glu Lys Val Leu Asn Glu Met Gln Lys
Gln Tyr Asp Glu Phe Leu 450 455 460Lys Asn Lys
Lys46511937DNAStreptococcus pneumoniae 11tggtcaagga actgcttcta
aagacaacaa agaggcagaa cttaagaagg ttgactttat 60cctagactgg acaccaaata
ccaaccacac agggctttat gttgccaagg aaaaaggtta 120tttcaaagaa
gctggagtgg atgttgattt gaaattgcca ccagaagaaa gttcttctga
180cttggttatc aacggaaagg caccatttgc agtgtatttc caagactaca
tggctaagaa 240attggaaaaa ggagcaggaa tcactgccgt tgcagctatt
gttgaacaca atacatcagg 300aatcatctct cgtaaatctg ataatgtaag
cagtccaaaa gacttggttg gtaagaaata 360tgggacatgg aatgacccaa
ctgaacttgc tatgttgaaa accttggtag aatctcaagg 420tggagacttt
gagaaggttg aaaaagtacc aaataacgac tcaaactcaa tcacaccgat
480tgccaatggc gtctttgata ctgcttggat ttactacggt tgggatggta
tccttgctaa 540atctcaaggt gtagatgcta acttcatgta cttgaaagac
tatgtcaagg agtttgacta 600ctattcacca gttatcatcg caaacaacga
ctatctgaaa gataacaaag aagaagctcg 660caaagtcatc caagccatca
aaaaaggcta ccaatatgcc atggaacatc cagaagaagc 720tgcagatatt
ctcatcaaga atgcacctga actcaaggaa aaacgtgact ttgtcatcga
780atctcaaaaa tacttgtcaa aagaatacgc aagcgacaag gaaaaatggg
gtcaatttga 840cgcagctcgc tggaatgctt tctacaaatg ggataaagaa
aatggtatcc ttaaagaaga 900cttgacagac aaaggcttca ccaacgaatt tgtgaaa
93712312PRTStreptococcus pneumoniae 12Gly Gln Gly Thr Ala Ser Lys
Asp Asn Lys Glu Ala Glu Leu Lys Lys1 5 10 15Val Asp Phe Ile Leu Asp
Trp Thr Pro Asn Thr Asn His Thr Gly Leu 20 25 30Tyr Val Ala Lys Glu
Lys Gly Tyr Phe Lys Glu Ala Gly Val Asp Val 35 40 45Asp Leu Lys Leu
Pro Pro Glu Glu Ser Ser Ser Asp Leu Val Ile Asn 50 55 60Gly Lys Ala
Pro Phe Ala Val Tyr Phe Gln Asp Tyr Met Ala Lys Lys65 70 75 80Leu
Glu Lys Gly Ala Gly Ile Thr Ala Val Ala Ala Ile Val Glu His 85 90
95Asn Thr Ser Gly Ile Ile Ser Arg Lys Ser Asp Asn Val Ser Ser Pro
100 105 110Lys Asp Leu Val Gly Lys Lys Tyr Gly Thr Trp Asn Asp Pro
Thr Glu 115 120 125Leu Ala Met Leu Lys Thr Leu Val Glu Ser Gln Gly
Gly Asp Phe Glu 130 135 140Lys Val Glu Lys Val Pro Asn Asn Asp Ser
Asn Ser Ile Thr Pro Ile145 150 155 160Ala Asn Gly Val Phe Asp Thr
Ala Trp Ile Tyr Tyr Gly Trp Asp Gly 165 170 175Ile Leu Ala Lys Ser
Gln Gly Val Asp Ala Asn Phe Met Tyr Leu Lys 180 185 190Asp Tyr Val
Lys Glu Phe Asp Tyr Tyr Ser Pro Val Ile Ile Ala Asn 195 200 205Asn
Asp Tyr Leu Lys Asp Asn Lys Glu Glu Ala Arg Lys Val Ile Gln 210 215
220Ala Ile Lys Lys Gly Tyr Gln Tyr Ala Met Glu His Pro Glu Glu
Ala225 230 235 240Ala Asp Ile Leu Ile Lys Asn Ala Pro Glu Leu Lys
Glu Lys Arg Asp 245 250 255Phe Val Ile Glu Ser Gln Lys Tyr Leu Ser
Lys Glu Tyr Ala Ser Asp 260 265 270Lys Glu Lys Trp Gly Gln Phe Asp
Ala Ala Arg Trp Asn Ala Phe Tyr 275 280 285Lys Trp Asp Lys Glu Asn
Gly Ile Leu Lys Glu Asp Leu Thr Asp Lys 290 295 300Gly Phe Thr Asn
Glu Phe Val Lys305 31013799DNAStreptococcus pneumoniae 13tagctcaggt
ggaaacgctg gttcatcctc tggaaaaaca actgccaaag ctcgcactat 60cgatgaaatc
aaaaaaagcg gtgaactgcg aatcgccgtg tttggagata aaaaaccgtt
120tggctacgtt gacaatgatg gttctaccaa ggtacgctac gatattgaac
tagggaacca 180actagctcaa gaccttggtg tcaaggttaa atacatttca
gtcgatgctg ccaaccgtgc 240ggaatacttg atttcaaaca aggtagatat
tactcttgct aactttacag taactgacga 300acgtaagaaa caagttgatt
ttgcccttcc atatatgaaa gtttctctgg gtgtcgtatc 360acctaagact
ggtctcatta cagacgtcaa acaacttgaa ggtaaaacct taattgtcac
420aaaaggaacg actgctgaga cttattttga aaagaatcat ccagaaatca
aactccaaaa 480atacgaccaa tacagtgact cttaccaagc tcttcttgac
ggacgtggag atgccttttc 540aactgacaat acggaagttc tagcttgggc
gcttgaaaat aaaggatttg aagtaggaat 600tacttccctc ggtgatcccg
ataccattgc ggcagcagtt caaaaaggca accaagaatt 660gctagacttc
atcaataaag atattgaaaa attaggcaag gaaaacttct tccacaaggc
720ctatgaaaag acacttcacc caacctacgg tgacgctgct aaagcagatg
acctggttgt 780tgaaggtgga aaagttgat 79914266PRTStreptococcus
pneumoniae 14Ser Ser Gly Gly Asn Ala Gly Ser Ser Ser Gly Lys Thr
Thr Ala Lys1 5 10 15Ala Arg Thr Ile Asp Glu Ile Lys Lys Ser Gly Glu
Leu Arg Ile Ala 20 25 30Val Phe Gly Asp Lys Lys Pro Phe Gly Tyr Val
Asp Asn Asp Gly Ser 35 40 45Thr Lys Val Arg Tyr Asp Ile Glu Leu Gly
Asn Gln Leu Ala Gln Asp 50 55 60Leu Gly Val Lys Val Lys Tyr Ile Ser
Val Asp Ala Ala Asn Arg Ala65 70 75 80Glu Tyr Leu Ile Ser Asn Lys
Val Asp Ile Thr Leu Ala Asn Phe Thr 85 90 95Val Thr Asp Glu Arg Lys
Lys Gln Val Asp Phe Ala Leu Pro Tyr Met 100 105 110Lys Val Ser Leu
Gly Val Val Ser Pro Lys Thr Gly Leu Ile Thr Asp 115 120 125Val Lys
Gln Leu Glu Gly Lys Thr Leu Ile Val Thr Lys Gly Thr Thr 130 135
140Ala Glu Thr Tyr Phe Glu Lys Asn His Pro Glu Ile Lys Leu Gln
Lys145 150 155 160Tyr Asp Gln Tyr Ser Asp Ser Tyr Gln Ala Leu Leu
Asp Gly Arg Gly 165 170 175Asp Ala Phe Ser Thr Asp Asn Thr Glu Val
Leu Ala Trp Ala Leu Glu 180 185 190Asn Lys Gly Phe Glu Val Gly Ile
Thr Ser Leu Gly Asp Pro Asp Thr 195 200 205Ile Ala Ala Ala Val Gln
Lys Gly Asn Gln Glu Leu Leu Asp Phe Ile 210 215 220Asn Lys Asp Ile
Glu Lys Leu Gly Lys Glu Asn Phe Phe His Lys Ala225 230 235 240Tyr
Glu Lys Thr Leu His Pro Thr Tyr Gly Asp Ala Ala Lys Ala Asp 245 250
255Asp Leu Val Val Glu Gly Gly Lys Val Asp 260
265151189DNAStreptococcus pneumoniae 15ctccaactat ggtaaatctg
cggatggcac agtgaccatc gagtatttca accagaaaaa 60agaaatgacc aaaaccttgg
aagaaatcac tcgtgatttt gagaaggaaa accctaagat 120caaggtcaaa
gtcgtcaatg taccaaatgc tggtgaagta ttgaagacac gcgttctcgc
180aggagatgtg cctgatgtgg tcaatattta cccacagtcc atcgaactgc
aagaatgggc 240aaaagcaggt gtttttgaag atttgagcaa caaagactac
ctgaaacgcg tgaaaaatgg 300ctacgctgaa aaatatgctg taaacgaaaa
agtttacaac gttcctttta cagctaatgc 360ttatggaatt tactacaaca
aagataaatt cgaagaactg ggcttgaagg ttcctgaaac 420ctgggatgaa
tttgaacagt tagtcaaaga tatcgttgct aaaggacaaa caccatttgg
480aattgcaggt gcagatgctt ggacactcaa tggttacaat caattagcct
ttgcgacagc 540aacaggtgga ggaaaagaag caaatcaata ccttcgttat
tctcaaccaa atgccattaa 600attgtcggat ccgattatga aagatgatat
caaggtcatg gacatccttc gcatcaatgg 660atctaagcaa aagaactggg
aaggtgctgg ctataccgat gttatcggag ccttcgcacg 720tggggatgtc
ctcatgacac caaatgggtc ttgggcgatc acagcgatta atgaacaaaa
780accgaacttt aagattggga ccttcatgat tccaggaaaa gaaaaaggac
aaagcttaac 840cgttggtgcg ggagacttgg catggtctat ctcagccacc
accaaacatc caaaagaagc 900caatgccttt gtggaatata tgacccgtcc
agaagtcatg caaaaatact acgatgtgga 960cggatctcca acagcgatcg
aaggggtcaa acaagcagga gaagattcac cgcttgctgg 1020tatgaccgaa
tatgccttta cggatcgtca cttggtctgg ttgcaacaat actggaccag
1080tgaagcagac ttccatacct tgaccatgaa ctatgtcttg accggtgata
aacaaggcat 1140ggtcaatgat ttgaatgcct tctttaaccc gatgaaagcg
gatgtggat 118916396PRTStreptococcus pneumoniae 16Ser Asn Tyr Gly
Lys Ser Ala Asp Gly Thr Val Thr Ile Glu Tyr Phe1 5 10 15Asn Gln Lys
Lys Glu Met Thr Lys Thr Leu Glu Glu Ile Thr Arg Asp 20 25 30Phe Glu
Lys Glu Asn Pro Lys Ile Lys Val Lys Val Val Asn Val Pro 35 40 45Asn
Ala Gly Glu Val Leu Lys Thr Arg Val Leu Ala Gly Asp Val Pro 50 55
60Asp Val Val Asn Ile Tyr Pro Gln Ser Ile Glu Leu Gln Glu Trp Ala65
70 75 80Lys Ala Gly Val Phe Glu Asp Leu Ser Asn Lys Asp Tyr Leu Lys
Arg 85 90 95Val Lys Asn Gly Tyr Ala Glu Lys Tyr Ala Val Asn Glu Lys
Val Tyr 100 105 110Asn Val Pro Phe Thr Ala Asn Ala Tyr Gly Ile Tyr
Tyr Asn Lys Asp 115 120 125Lys Phe Glu Glu Leu Gly Leu Lys Val Pro
Glu Thr Trp Asp Glu Phe 130 135 140Glu Gln Leu Val Lys Asp Ile Val
Ala Lys Gly Gln Thr Pro Phe Gly145 150 155 160Ile Ala Gly Ala Asp
Ala Trp Thr Leu Asn Gly Tyr Asn Gln Leu Ala 165 170 175Phe Ala Thr
Ala Thr Gly Gly Gly Lys Glu Ala Asn Gln Tyr Leu Arg 180 185 190Tyr
Ser Gln Pro Asn Ala Ile Lys Leu Ser Asp Pro Ile Met Lys Asp 195 200
205Asp Ile Lys Val Met Asp Ile Leu Arg Ile Asn Gly Ser Lys Gln Lys
210 215 220Asn Trp Glu Gly Ala Gly Tyr Thr Asp Val Ile Gly Ala Phe
Ala Arg225 230 235 240Gly Asp Val Leu Met Thr Pro Asn Gly Ser Trp
Ala Ile Thr Ala Ile 245 250 255Asn Glu Gln Lys Pro Asn Phe Lys Ile
Gly Thr Phe Met Ile Pro Gly 260 265 270Lys Glu Lys Gly Gln Ser Leu
Thr Val Gly Ala Gly Asp Leu Ala Trp 275 280 285Ser Ile Ser Ala Thr
Thr Lys His Pro Lys Glu Ala Asn Ala Phe Val 290 295 300Glu Tyr Met
Thr Arg Pro Glu Val Met Gln Lys Tyr Tyr Asp Val Asp305 310 315
320Gly Ser Pro Thr Ala Ile Glu Gly Val Lys Gln Ala Gly Glu Asp Ser
325 330 335Pro Leu Ala Gly Met Thr Glu Tyr Ala Phe Thr Asp Arg His
Leu Val 340 345 350Trp
Leu Gln Gln Tyr Trp Thr Ser Glu Ala Asp Phe His Thr Leu Thr 355 360
365Met Asn Tyr Val Leu Thr Gly Asp Lys Gln Gly Met Val Asn Asp Leu
370 375 380Asn Ala Phe Phe Asn Pro Met Lys Ala Asp Val Asp385 390
39517775DNAStreptococcus pneumoniae 17tgggaaaaat tctagcgaaa
ctagtggaga taattggtca aagtaccagt ctaacaagtc 60tattactatt ggatttgata
gtacttttgt tccaatggga tttgctcaga aagatggttc 120ttatgcagga
tttgatattg atttagctac agctgttttt gaaaaatacg gaatcacggt
180aaattggcaa ccgattgatt gggatttgaa agaagctgaa ttgacaaaag
gaacgattga 240tctgatttgg aatggctatt ccgctacaga cgaacgccgt
gaaaaggtgg ctttcagtaa 300ctcatatatg aagaatgagc aggtattggt
tacgaagaaa tcatctggta tcacgactgc 360aaaggatatg actggaaaga
cattaggagc tcaagctggt tcatctggtt atgcggactt 420tgaagcaaat
ccagaaattt tgaagaatat tgtcgctaat aaggaagcga atcaatacca
480aacctttaat gaagccttga ttgatttgaa aaacgatcga attgatggtc
tattgattga 540ccgtgtctat gcaaactatt atttagaagc agaaggtgtt
ttaaacgatt ataatgtctt 600tacagttgga ctagaaacag aagcttttgc
ggttggagcc cgtaaggaag atacaaactt 660ggttaagaag ataaatgaag
ctttttctag tctttacaag gacggcaagt tccaagaaat 720cagccaaaaa
tggtttggag aagatgtagc aaccaaagaa gtaaaagaag gacag
77518258PRTStreptococcus pneumoniae 18Gly Lys Asn Ser Ser Glu Thr
Ser Gly Asp Asn Trp Ser Lys Tyr Gln1 5 10 15Ser Asn Lys Ser Ile Thr
Ile Gly Phe Asp Ser Thr Phe Val Pro Met 20 25 30Gly Phe Ala Gln Lys
Asp Gly Ser Tyr Ala Gly Phe Asp Ile Asp Leu 35 40 45Ala Thr Ala Val
Phe Glu Lys Tyr Gly Ile Thr Val Asn Trp Gln Pro 50 55 60Ile Asp Trp
Asp Leu Lys Glu Ala Glu Leu Thr Lys Gly Thr Ile Asp65 70 75 80Leu
Ile Trp Asn Gly Tyr Ser Ala Thr Asp Glu Arg Arg Glu Lys Val 85 90
95Ala Phe Ser Asn Ser Tyr Met Lys Asn Glu Gln Val Leu Val Thr Lys
100 105 110Lys Ser Ser Gly Ile Thr Thr Ala Lys Asp Met Thr Gly Lys
Thr Leu 115 120 125Gly Ala Gln Ala Gly Ser Ser Gly Tyr Ala Asp Phe
Glu Ala Asn Pro 130 135 140Glu Ile Leu Lys Asn Ile Val Ala Asn Lys
Glu Ala Asn Gln Tyr Gln145 150 155 160Thr Phe Asn Glu Ala Leu Ile
Asp Leu Lys Asn Asp Arg Ile Asp Gly 165 170 175Leu Leu Ile Asp Arg
Val Tyr Ala Asn Tyr Tyr Leu Glu Ala Glu Gly 180 185 190Val Leu Asn
Asp Tyr Asn Val Phe Thr Val Gly Leu Glu Thr Glu Ala 195 200 205Phe
Ala Val Gly Ala Arg Lys Glu Asp Thr Asn Leu Val Lys Lys Ile 210 215
220Asn Glu Ala Phe Ser Ser Leu Tyr Lys Asp Gly Lys Phe Gln Glu
Ile225 230 235 240Ser Gln Lys Trp Phe Gly Glu Asp Val Ala Thr Lys
Glu Val Lys Glu 245 250 255Gly Gln19868DNAStreptococcus pneumoniae
19tgctagcgga aaaaaagata caacttctgg tcaaaaacta aaagttgttg ctacaaactc
60aatcatcgct gatattacta aaaatattgc tggtgacaaa attgaccttc atagtatcgt
120tccgattggg caagacccac acgaatacga accacttcct gaagacgtta
agaaaacttc 180tgaggctaat ttgattttct ataacggtat caaccttgaa
acaggtggca atgcttggtt 240tacaaaattg gtagaaaatg ccaagaaaac
tgaaaacaaa gactacttcg cagtcagcga 300cggcgttgat gttatctacc
ttgaaggtca aaatgaaaaa ggaaaagaag acccacacgc 360ttggcttaac
cttgaaaacg gtattatttt tgctaaaaat atcgccaaac aattgagcgc
420caaagaccct aacaataaag aattctatga aaaaaatctc aaagaatata
ctgataagtt 480agacaaactt gataaagaaa gtaaggataa atttaataag
atccctgctg aaaagaaact 540cattgtaacc agcgaaggag cattcaaata
cttctctaaa gcctatggtg tcccaagtgc 600ttacatctgg gaaatcaata
ctgaagaaga aggaactcct gaacaaatca agaccttggt 660tgaaaaactt
cgccaaacaa aagttccatc actctttgta gaatcaagtg tggatgaccg
720tccaatgaaa actgtttctc aagacacaaa catcccaatc tacgctcaaa
tctttactga 780ctctatcgca gaacaaggta aagaaggcga cagctactac
agcatgatga aatacaacct 840tgacaagatt gctgaaggat tggcaaaa
86820289PRTStreptococcus pneumoniae 20Ala Ser Gly Lys Lys Asp Thr
Thr Ser Gly Gln Lys Leu Lys Val Val1 5 10 15Ala Thr Asn Ser Ile Ile
Ala Asp Ile Thr Lys Asn Ile Ala Gly Asp 20 25 30Lys Ile Asp Leu His
Ser Ile Val Pro Ile Gly Gln Asp Pro His Glu 35 40 45Tyr Glu Pro Leu
Pro Glu Asp Val Lys Lys Thr Ser Glu Ala Asn Leu 50 55 60Ile Phe Tyr
Asn Gly Ile Asn Leu Glu Thr Gly Gly Asn Ala Trp Phe65 70 75 80Thr
Lys Leu Val Glu Asn Ala Lys Lys Thr Glu Asn Lys Asp Tyr Phe 85 90
95Ala Val Ser Asp Gly Val Asp Val Ile Tyr Leu Glu Gly Gln Asn Glu
100 105 110Lys Gly Lys Glu Asp Pro His Ala Trp Leu Asn Leu Glu Asn
Gly Ile 115 120 125Ile Phe Ala Lys Asn Ile Ala Lys Gln Leu Ser Ala
Lys Asp Pro Asn 130 135 140Asn Lys Glu Phe Tyr Glu Lys Asn Leu Lys
Glu Tyr Thr Asp Lys Leu145 150 155 160Asp Lys Leu Asp Lys Glu Ser
Lys Asp Lys Phe Asn Lys Ile Pro Ala 165 170 175Glu Lys Lys Leu Ile
Val Thr Ser Glu Gly Ala Phe Lys Tyr Phe Ser 180 185 190Lys Ala Tyr
Gly Val Pro Ser Ala Tyr Ile Trp Glu Ile Asn Thr Glu 195 200 205Glu
Glu Gly Thr Pro Glu Gln Ile Lys Thr Leu Val Glu Lys Leu Arg 210 215
220Gln Thr Lys Val Pro Ser Leu Phe Val Glu Ser Ser Val Asp Asp
Arg225 230 235 240Pro Met Lys Thr Val Ser Gln Asp Thr Asn Ile Pro
Ile Tyr Ala Gln 245 250 255Ile Phe Thr Asp Ser Ile Ala Glu Gln Gly
Lys Glu Gly Asp Ser Tyr 260 265 270Tyr Ser Met Met Lys Tyr Asn Leu
Asp Lys Ile Ala Glu Gly Leu Ala 275 280
285Lys211546DNAStreptococcus pneumoniae 21tggctcaaaa aatacagctt
caagtccaga ttataagttg gaaggtgtaa cattcccgct 60tcaagaaaag aaaacattga
agtttatgac agccagttca ccgttatctc ctaaagaccc 120aaatgaaaag
ttaattttgc aacgtttgga gaaggaaact ggcgttcata ttgactggac
180caactaccaa tccgactttg cagaaaaacg taacttggat atttctagtg
gtgatttacc 240agatgctatc cacaacgacg gagcttcaga tgtggacttg
atgaactggg ctaaaaaagg 300tgttattatt ccagttgaag atttgattga
taaatacatg ccaaatctta agaaaatttt 360ggatgagaaa ccagagtaca
aggccttgat gacagcacct gatgggcaca tttactcatt 420tccatggatt
gaagagcttg gagatggtaa agagtctatt cacagtgtca acgatatggc
480ttggattaac aaagattggc ttaagaaact tggtcttgaa atgccaaaaa
ctactgatga 540tttgattaaa gtcctagaag ctttcaaaaa cggggatcca
aatggaaatg gagaggctga 600tgaaattcca ttttcattta ttagtggtaa
cggaaacgaa gattttaaat tcctatttgc 660tgcatttggt ataggggata
acgatgatca tttagtagta ggaaatgatg gcaaagttga 720cttcacagca
gataacgata actataaaga aggtgtcaaa tttatccgtc aattgcaaga
780aaaaggcctg attgataaag aagctttcga acatgattgg aatagttaca
ttgctaaagg 840tcatgatcag aaatttggtg tttactttac atgggataag
aataatgtta ctggaagtaa 900cgaaagttat gatgttttac cagtacttgc
tggaccaagt ggtcaaaaac acgtagctcg 960tacaaacggt atgggatttg
cacgtgacaa gatggttatt accagtgtaa acaaaaacct 1020agaattgaca
gctaaatgga ttgatgcaca atacgctcca ctccaatctg tgcaaaataa
1080ctggggaact tacggagatg acaaacaaca aaacatcttt gaattggatc
aagcgtcaaa 1140tagtctaaaa cacttaccac taaacggaac tgcaccagca
gaacttcgtc aaaagactga 1200agtaggagga ccactagcta tcctagattc
atactatggt aaagtaacaa ccatgcctga 1260tgatgccaaa tggcgtttgg
atcttatcaa agaatattat gttccttaca tgagcaatgt 1320caataactat
ccaagagtct ttatgacaca ggaagatttg gacaagattg cccatatcga
1380agcagatatg aatgactata tctaccgtaa acgtgctgaa tggattgtaa
atggcaatat 1440tgatactgag tgggatgatt acaagaaaga acttgaaaaa
tacggacttt ctgattacct 1500cgctattaaa caaaaatact acgaccaata
ccaagcaaac aaaaac 154622515PRTStreptococcus pneumoniae 22Gly Ser
Lys Asn Thr Ala Ser Ser Pro Asp Tyr Lys Leu Glu Gly Val1 5 10 15Thr
Phe Pro Leu Gln Glu Lys Lys Thr Leu Lys Phe Met Thr Ala Ser 20 25
30Ser Pro Leu Ser Pro Lys Asp Pro Asn Glu Lys Leu Ile Leu Gln Arg
35 40 45Leu Glu Lys Glu Thr Gly Val His Ile Asp Trp Thr Asn Tyr Gln
Ser 50 55 60Asp Phe Ala Glu Lys Arg Asn Leu Asp Ile Ser Ser Gly Asp
Leu Pro65 70 75 80Asp Ala Ile His Asn Asp Gly Ala Ser Asp Val Asp
Leu Met Asn Trp 85 90 95Ala Lys Lys Gly Val Ile Ile Pro Val Glu Asp
Leu Ile Asp Lys Tyr 100 105 110Met Pro Asn Leu Lys Lys Ile Leu Asp
Glu Lys Pro Glu Tyr Lys Ala 115 120 125Leu Met Thr Ala Pro Asp Gly
His Ile Tyr Ser Phe Pro Trp Ile Glu 130 135 140Glu Leu Gly Asp Gly
Lys Glu Ser Ile His Ser Val Asn Asp Met Ala145 150 155 160Trp Ile
Asn Lys Asp Trp Leu Lys Lys Leu Gly Leu Glu Met Pro Lys 165 170
175Thr Thr Asp Asp Leu Ile Lys Val Leu Glu Ala Phe Lys Asn Gly Asp
180 185 190Pro Asn Gly Asn Gly Glu Ala Asp Glu Ile Pro Phe Ser Phe
Ile Ser 195 200 205Gly Asn Gly Asn Glu Asp Phe Lys Phe Leu Phe Ala
Ala Phe Gly Ile 210 215 220Gly Asp Asn Asp Asp His Leu Val Val Gly
Asn Asp Gly Lys Val Asp225 230 235 240Phe Thr Ala Asp Asn Asp Asn
Tyr Lys Glu Gly Val Lys Phe Ile Arg 245 250 255Gln Leu Gln Glu Lys
Gly Leu Ile Asp Lys Glu Ala Phe Glu His Asp 260 265 270Trp Asn Ser
Tyr Ile Ala Lys Gly His Asp Gln Lys Phe Gly Val Tyr 275 280 285Phe
Thr Trp Asp Lys Asn Asn Val Thr Gly Ser Asn Glu Ser Tyr Asp 290 295
300Val Leu Pro Val Leu Ala Gly Pro Ser Gly Gln Lys His Val Ala
Arg305 310 315 320Thr Asn Gly Met Gly Phe Ala Arg Asp Lys Met Val
Ile Thr Ser Val 325 330 335Asn Lys Asn Leu Glu Leu Thr Ala Lys Trp
Ile Asp Ala Gln Tyr Ala 340 345 350Pro Leu Gln Ser Val Gln Asn Asn
Trp Gly Thr Tyr Gly Asp Asp Lys 355 360 365Gln Gln Asn Ile Phe Glu
Leu Asp Gln Ala Ser Asn Ser Leu Lys His 370 375 380Leu Pro Leu Asn
Gly Thr Ala Pro Ala Glu Leu Arg Gln Lys Thr Glu385 390 395 400Val
Gly Gly Pro Leu Ala Ile Leu Asp Ser Tyr Tyr Gly Lys Val Thr 405 410
415Thr Met Pro Asp Asp Ala Lys Trp Arg Leu Asp Leu Ile Lys Glu Tyr
420 425 430Tyr Val Pro Tyr Met Ser Asn Val Asn Asn Tyr Pro Arg Val
Phe Met 435 440 445Thr Gln Glu Asp Leu Asp Lys Ile Ala His Ile Glu
Ala Asp Met Asn 450 455 460Asp Tyr Ile Tyr Arg Lys Arg Ala Glu Trp
Ile Val Asn Gly Asn Ile465 470 475 480Asp Thr Glu Trp Asp Asp Tyr
Lys Lys Glu Leu Glu Lys Tyr Gly Leu 485 490 495Ser Asp Tyr Leu Ala
Ile Lys Gln Lys Tyr Tyr Asp Gln Tyr Gln Ala 500 505 510Asn Lys Asn
51523895DNAStreptococcus pneumoniae 23tagtacaaac tcaagcacta
gtcagacaga gaccagtagc tctgctccaa cagaggtaac 60cattaaaagt tcactggacg
aggtcaaact ttccaaagtt cctgaaaaga ttgtgacctt 120tgacctcggc
gctgcggata ctattcgcgc tttaggattt gaaaaaaata tcgtcggaat
180gcctacaaaa actgttccga cttatctaaa agacctagtg ggaactgtca
aaaatgttgg 240ttctatgaaa gaacctgatt tagaagctat cgccgccctt
gagcctgatt tgattatcgc 300ttcgccacgt acacaaaaat tcgtagacaa
attcaaagaa atcgccccaa ccgttctctt 360ccaagcaagc aaggacgact
actggacttc taccaaggct aatatcgaat ccttagcaag 420tgccttcggc
gaaactggta cacagaaagc caaggaagaa ttgaccaagc tagacaagag
480catccaagaa gtcgctacta aaaatgaaag ctctgacaaa aaagcccttg
cgatcctcct 540taatgaagga aaaatggcag cctttggtgc caaatctcgt
ttctctttct tgtaccaaac 600cttgaaattc aaaccaactg atacaaaatt
tgaagactca cgccacggac aagaagtcag 660ctttgaaagt gtcaaagaaa
tcaaccctga catcctcttt gtcatcaacc gtacccttgc 720catcggtggg
gacaactcta gcaacgacgg tgtcctagaa aatgccctta tcgctgaaac
780acctgctgct aaaaatggta agattatcca actaacacca gacctctggt
atctaagcgg 840aggcggactt gaatcaacaa aactcatgat tgaagacata
caaaaagctt tgaaa 89524298PRTStreptococcus pneumoniae 24Ser Thr Asn
Ser Ser Thr Ser Gln Thr Glu Thr Ser Ser Ser Ala Pro1 5 10 15Thr Glu
Val Thr Ile Lys Ser Ser Leu Asp Glu Val Lys Leu Ser Lys 20 25 30Val
Pro Glu Lys Ile Val Thr Phe Asp Leu Gly Ala Ala Asp Thr Ile 35 40
45Arg Ala Leu Gly Phe Glu Lys Asn Ile Val Gly Met Pro Thr Lys Thr
50 55 60Val Pro Thr Tyr Leu Lys Asp Leu Val Gly Thr Val Lys Asn Val
Gly65 70 75 80Ser Met Lys Glu Pro Asp Leu Glu Ala Ile Ala Ala Leu
Glu Pro Asp 85 90 95Leu Ile Ile Ala Ser Pro Arg Thr Gln Lys Phe Val
Asp Lys Phe Lys 100 105 110Glu Ile Ala Pro Thr Val Leu Phe Gln Ala
Ser Lys Asp Asp Tyr Trp 115 120 125Thr Ser Thr Lys Ala Asn Ile Glu
Ser Leu Ala Ser Ala Phe Gly Glu 130 135 140Thr Gly Thr Gln Lys Ala
Lys Glu Glu Leu Thr Lys Leu Asp Lys Ser145 150 155 160Ile Gln Glu
Val Ala Thr Lys Asn Glu Ser Ser Asp Lys Lys Ala Leu 165 170 175Ala
Ile Leu Leu Asn Glu Gly Lys Met Ala Ala Phe Gly Ala Lys Ser 180 185
190Arg Phe Ser Phe Leu Tyr Gln Thr Leu Lys Phe Lys Pro Thr Asp Thr
195 200 205Lys Phe Glu Asp Ser Arg His Gly Gln Glu Val Ser Phe Glu
Ser Val 210 215 220Lys Glu Ile Asn Pro Asp Ile Leu Phe Val Ile Asn
Arg Thr Leu Ala225 230 235 240Ile Gly Gly Asp Asn Ser Ser Asn Asp
Gly Val Leu Glu Asn Ala Leu 245 250 255Ile Ala Glu Thr Pro Ala Ala
Lys Asn Gly Lys Ile Ile Gln Leu Thr 260 265 270Pro Asp Leu Trp Tyr
Leu Ser Gly Gly Gly Leu Glu Ser Thr Lys Leu 275 280 285Met Ile Glu
Asp Ile Gln Lys Ala Leu Lys 290 295251261DNAStreptococcus
pneumoniae 25tggcaattct ggcggaagta aagatgctgc caaatcaggt ggtgacggtg
ccaaaacaga 60aatcacttgg tgggcattcc cagtatttac ccaagaaaaa actggtgacg
gtgttggaac 120ttatgaaaaa tcaatcatcg aagcgtttga aaaagcaaac
ccagatataa aagtgaaatt 180ggaaaccatc gacttcaagt caggtcctga
aaaaatcaca acagccatcg aagcaggaac 240agctccagac gtactctttg
atgcaccagg acgtatcatc caatacggta aaaacggtaa 300attggctgag
ttgaatgacc tcttcacaga tgaatttgtt aaagatgtca acaatgaaaa
360catcgtacaa gcaagtaaag ctggagacaa ggcttatatg tatccgatta
gttctgcccc 420attctacatg gcaatgaaca agaaaatgtt agaagatgct
ggagtagcaa accttgtaaa 480agaaggttgg acaactgatg attttgaaaa
agtattgaaa gcacttaaag acaagggtta 540cacaccaggt tcattgttca
gttctggtca agggggagac caaggaacac gtgcctttat 600ctctaacctt
tatagcggtt ctgtaacaga tgaaaaagtt agcaaatata caactgatga
660tcctaaattc gtcaaaggtc ttgaaaaagc aactagctgg attaaagaca
atttgatcaa 720taatggttca caatttgacg gtggggcaga tatccaaaac
tttgccaacg gtcaaacatc 780ttacacaatc ctttgggcac cagctcaaaa
tggtatccaa gctaaacttt tagaagcaag 840taaggtagaa gtggtagaag
taccattccc atcagacgaa ggtaagccag ctcttgagta 900ccttgtaaac
gggtttgcag tattcaacaa taaagacgac aagaaagtcg ctgcatctaa
960gaaattcatc cagtttatcg cagatgacaa ggagtgggga cctaaagacg
tagttcgtac 1020aggtgctttc ccagtccgta cttcatttgg aaaactttat
gaagacaaac gcatggaaac 1080aatcagcggc tggactcaat actactcacc
atactacaac actattgatg gatttgctga 1140aatgagaaca ctttggttcc
caatgttgca atctgtatca aatggtgacg aaaaaccagc 1200agatgctttg
aaagccttca ctgaaaaagc gaacgaaaca atcaaaaaag ctatgaaaca 1260a
126126420PRTStreptococcus pneumoniae 26Gly Asn Ser Gly Gly Ser Lys
Asp Ala Ala Lys Ser Gly Gly Asp Gly1 5 10 15Ala Lys Thr Glu Ile Thr
Trp Trp Ala Phe Pro Val Phe Thr Gln Glu 20 25 30Lys Thr Gly Asp Gly
Val Gly Thr Tyr Glu Lys Ser Ile Ile Glu Ala 35 40 45Phe Glu Lys Ala
Asn Pro Asp Ile Lys Val Lys Leu Glu Thr Ile Asp 50 55 60Phe Lys Ser
Gly Pro Glu Lys Ile Thr Thr Ala Ile Glu Ala Gly Thr65 70 75 80Ala
Pro Asp Val Leu Phe Asp Ala Pro Gly Arg Ile Ile Gln Tyr Gly 85 90
95Lys Asn Gly Lys Leu Ala Glu Leu Asn Asp Leu Phe Thr Asp Glu Phe
100 105 110Val Lys Asp Val Asn Asn Glu Asn Ile Val Gln Ala Ser Lys
Ala Gly 115 120 125Asp Lys
Ala Tyr Met Tyr Pro Ile Ser Ser Ala Pro Phe Tyr Met Ala 130 135
140Met Asn Lys Lys Met Leu Glu Asp Ala Gly Val Ala Asn Leu Val
Lys145 150 155 160Glu Gly Trp Thr Thr Asp Asp Phe Glu Lys Val Leu
Lys Ala Leu Lys 165 170 175Asp Lys Gly Tyr Thr Pro Gly Ser Leu Phe
Ser Ser Gly Gln Gly Gly 180 185 190Asp Gln Gly Thr Arg Ala Phe Ile
Ser Asn Leu Tyr Ser Gly Ser Val 195 200 205Thr Asp Glu Lys Val Ser
Lys Tyr Thr Thr Asp Asp Pro Lys Phe Val 210 215 220Lys Gly Leu Glu
Lys Ala Thr Ser Trp Ile Lys Asp Asn Leu Ile Asn225 230 235 240Asn
Gly Ser Gln Phe Asp Gly Gly Ala Asp Ile Gln Asn Phe Ala Asn 245 250
255Gly Gln Thr Ser Tyr Thr Ile Leu Trp Ala Pro Ala Gln Asn Gly Ile
260 265 270Gln Ala Lys Leu Leu Glu Ala Ser Lys Val Glu Val Val Glu
Val Pro 275 280 285Phe Pro Ser Asp Glu Gly Lys Pro Ala Leu Glu Tyr
Leu Val Asn Gly 290 295 300Phe Ala Val Phe Asn Asn Lys Asp Asp Lys
Lys Val Ala Ala Ser Lys305 310 315 320Lys Phe Ile Gln Phe Ile Ala
Asp Asp Lys Glu Trp Gly Pro Lys Asp 325 330 335Val Val Arg Thr Gly
Ala Phe Pro Val Arg Thr Ser Phe Gly Lys Leu 340 345 350Tyr Glu Asp
Lys Arg Met Glu Thr Ile Ser Gly Trp Thr Gln Tyr Tyr 355 360 365Ser
Pro Tyr Tyr Asn Thr Ile Asp Gly Phe Ala Glu Met Arg Thr Leu 370 375
380Trp Phe Pro Met Leu Gln Ser Val Ser Asn Gly Asp Glu Lys Pro
Ala385 390 395 400Asp Ala Leu Lys Ala Phe Thr Glu Lys Ala Asn Glu
Thr Ile Lys Lys 405 410 415Ala Met Lys Gln 42027658DNAStreptococcus
pneumoniae 27ttcacaagaa aaaacaaaaa atgaagatgg agaaactaag acagaacaga
cagccaaagc 60tgatggaaca gtcggtagta agtctcaagg agctgcccag aagaaagcag
aagtggtcaa 120taaaggtgat tactacagca ttcaagggaa atacgatgaa
atcatcgtag ccaacaaaca 180ctatccattg tctaaagact ataatccagg
ggaaaatcca acagccaagg cagagttggt 240caaactcatc aaagcgatgc
aagaggcagg tttccctatt agtgatcatt acagtggttt 300tagaagttat
gaaactcaga ccaagctcta tcaagattat gtcaaccaag atggaaaggc
360agcagctgac cgttactctg cccgtcctgg ctatagcgaa caccagacag
gcttggcctt 420tgatgtgatt gggactgatg gtgatttggt gacagaagaa
aaagcagccc aatggctctt 480ggatcatgca gctgattatg gctttgttgt
ccgttatctc aaaggcaagg aaaaggaaac 540aggctatatg gctgaagaat
ggcacctgcg ttatgtagga aaagaagcta aagaaattgc 600tgcaagtggt
ctcagtttgg aagaatacta tggctttgaa ggcggagact acgtcgat
65828219PRTStreptococcus pneumoniae 28Ser Gln Glu Lys Thr Lys Asn
Glu Asp Gly Glu Thr Lys Thr Glu Gln1 5 10 15Thr Ala Lys Ala Asp Gly
Thr Val Gly Ser Lys Ser Gln Gly Ala Ala 20 25 30Gln Lys Lys Ala Glu
Val Val Asn Lys Gly Asp Tyr Tyr Ser Ile Gln 35 40 45Gly Lys Tyr Asp
Glu Ile Ile Val Ala Asn Lys His Tyr Pro Leu Ser 50 55 60Lys Asp Tyr
Asn Pro Gly Glu Asn Pro Thr Ala Lys Ala Glu Leu Val65 70 75 80Lys
Leu Ile Lys Ala Met Gln Glu Ala Gly Phe Pro Ile Ser Asp His 85 90
95Tyr Ser Gly Phe Arg Ser Tyr Glu Thr Gln Thr Lys Leu Tyr Gln Asp
100 105 110Tyr Val Asn Gln Asp Gly Lys Ala Ala Ala Asp Arg Tyr Ser
Ala Arg 115 120 125Pro Gly Tyr Ser Glu His Gln Thr Gly Leu Ala Phe
Asp Val Ile Gly 130 135 140Thr Asp Gly Asp Leu Val Thr Glu Glu Lys
Ala Ala Gln Trp Leu Leu145 150 155 160Asp His Ala Ala Asp Tyr Gly
Phe Val Val Arg Tyr Leu Lys Gly Lys 165 170 175Glu Lys Glu Thr Gly
Tyr Met Ala Glu Glu Trp His Leu Arg Tyr Val 180 185 190Gly Lys Glu
Ala Lys Glu Ile Ala Ala Ser Gly Leu Ser Leu Glu Glu 195 200 205Tyr
Tyr Gly Phe Glu Gly Gly Asp Tyr Val Asp 210
21529790DNAStreptococcus pneumoniae 29gaaaggtctg tggtcaaata
atcttacctg cggttatgat gaaaaaataa tcttggaaaa 60tataaatata aaaatacctg
aagaaaaaat atcagttatt attgggtcaa atggttgtgg 120gaaatcaaca
ctcattaaaa ccttgtctcg acttataaag ccattagagg gagaagtatt
180gcttgataat aaatcaatta attcttataa agaaaaagat ttagcaaaac
acatagctat 240attacctcaa tctccaataa tccctgaatc aataacagta
gctgatcttg taagccgtgg 300tcgtttcccc tacagaaagc cttttaagag
tcttggaaaa gatgaccttg aaataataaa 360cagatcaatg gttaaggcca
atgttgaaga tctagcaaat aacctagttg aagaactttc 420tgggggtcaa
aggcaaagag tatggatagc tctagcccta gcccaagata caagtatcct
480acttttagat gagccaacta cttacttgga tatctcatat caaatagaac
tattagacct 540cttgactgat ctaaaccaaa aatataagac aaccatttgc
atgattttgc acgatataaa 600tctaacagca agatacgctg attacctatt
tgcaattaaa gaaggtaaac ttgttgcaga 660gggaaagcct gaagatatac
taaatgataa actagttaaa gatatcttta atcttgaagc 720aaaaattata
cgtgacccta tttccaattc gcctctaatg attcctattg gcaagcacca
780tgttaactct 79030262PRTStreptococcus pneumoniae 30Lys Gly Leu Trp
Ser Asn Asn Leu Thr Cys Gly Tyr Asp Glu Lys Ile1 5 10 15Ile Leu Glu
Asn Ile Asn Ile Lys Ile Pro Glu Glu Lys Ile Ser Val 20 25 30Ile Ile
Gly Ser Asn Gly Cys Gly Lys Ser Thr Leu Ile Lys Thr Leu 35 40 45Ser
Arg Leu Ile Lys Pro Leu Glu Gly Glu Val Leu Leu Asp Asn Lys 50 55
60Ser Ile Asn Ser Tyr Lys Glu Lys Asp Leu Ala Lys His Ile Ala Ile65
70 75 80Leu Pro Gln Ser Pro Ile Ile Pro Glu Ser Ile Thr Val Ala Asp
Leu 85 90 95Val Ser Arg Gly Arg Phe Pro Tyr Arg Lys Pro Phe Lys Ser
Leu Gly 100 105 110Lys Asp Asp Leu Glu Ile Ile Asn Arg Ser Met Val
Lys Ala Asn Val 115 120 125Glu Asp Leu Ala Asn Asn Leu Val Glu Glu
Leu Ser Gly Gly Gln Arg 130 135 140Gln Arg Val Trp Ile Ala Leu Ala
Leu Ala Gln Asp Thr Ser Ile Leu145 150 155 160Leu Leu Asp Glu Pro
Thr Thr Tyr Leu Asp Ile Ser Tyr Gln Ile Glu 165 170 175Leu Leu Asp
Leu Leu Thr Asp Leu Asn Gln Lys Tyr Lys Thr Thr Ile 180 185 190Cys
Met Ile Leu His Asp Ile Asn Leu Thr Ala Arg Tyr Ala Asp Tyr 195 200
205Leu Phe Ala Ile Lys Glu Gly Lys Leu Val Ala Glu Gly Lys Pro Glu
210 215 220Asp Ile Leu Asn Asp Lys Leu Val Lys Asp Ile Phe Asn Leu
Glu Ala225 230 235 240Lys Ile Ile Arg Asp Pro Ile Ser Asn Ser Pro
Leu Met Ile Pro Ile 245 250 255Gly Lys His His Val Ser
26031781DNAStreptococcus pneumoniae 31aaactcagaa aagaaagcag
acaatgcaac aactatcaaa atcgcaactg ttaaccgtag 60cggttctgaa gaaaaacgtt
gggacaaaat ccaagaattg gttaaaaaag acggaattac 120cttggaattt
acagagttca cagactactc acaaccaaac aaagcaactg ctgatggcga
180agtagatttg aacgctttcc aacactataa cttcttgaac aactggaaca
aagaaaacgg 240aaaagacctt gtagcgattg cagatactta catctctcca
atccgccttt actcaggttt 300gaatggaagt gccaacaagt acactaaagt
agaagacatc ccagcaaacg gagaaatcgc 360tgtaccgaat gacgctacaa
acgaaagccg tgcgctttat ttgcttcaat cagctggctt 420gattaaattg
gatgtttctg gaactgctct tgcaacagtt gccaacatca aagaaaatcc
480aaagaacttg aaaatcactg aattggacgc tagccaaaca gctcgttcat
tgtcatcagt 540tgacgctgcc gttgtaaaca ataccttcgt tacagaagca
aaattggact acaagaaatc 600acttttcaaa gaacaagctg atgaaaactc
aaaacaatgg tacaacatca ttgttgcaaa 660aaaagattgg gaaacatcac
ctaaggctga tgctatcaag aaagtaatcg cagcttacca 720cacagatgac
gtgaaaaaag ttatcgaaga atcatcagat ggtttggatc aaccagtttg 780g
78132260PRTStreptococcus pneumoniae 32Asn Ser Glu Lys Lys Ala Asp
Asn Ala Thr Thr Ile Lys Ile Ala Thr1 5 10 15Val Asn Arg Ser Gly Ser
Glu Glu Lys Arg Trp Asp Lys Ile Gln Glu 20 25 30Leu Val Lys Lys Asp
Gly Ile Thr Leu Glu Phe Thr Glu Phe Thr Asp 35 40 45Tyr Ser Gln Pro
Asn Lys Ala Thr Ala Asp Gly Glu Val Asp Leu Asn 50 55 60Ala Phe Gln
His Tyr Asn Phe Leu Asn Asn Trp Asn Lys Glu Asn Gly65 70 75 80Lys
Asp Leu Val Ala Ile Ala Asp Thr Tyr Ile Ser Pro Ile Arg Leu 85 90
95Tyr Ser Gly Leu Asn Gly Ser Ala Asn Lys Tyr Thr Lys Val Glu Asp
100 105 110Ile Pro Ala Asn Gly Glu Ile Ala Val Pro Asn Asp Ala Thr
Asn Glu 115 120 125Ser Arg Ala Leu Tyr Leu Leu Gln Ser Ala Gly Leu
Ile Lys Leu Asp 130 135 140Val Ser Gly Thr Ala Leu Ala Thr Val Ala
Asn Ile Lys Glu Asn Pro145 150 155 160Lys Asn Leu Lys Ile Thr Glu
Leu Asp Ala Ser Gln Thr Ala Arg Ser 165 170 175Leu Ser Ser Val Asp
Ala Ala Val Val Asn Asn Thr Phe Val Thr Glu 180 185 190Ala Lys Leu
Asp Tyr Lys Lys Ser Leu Phe Lys Glu Gln Ala Asp Glu 195 200 205Asn
Ser Lys Gln Trp Tyr Asn Ile Ile Val Ala Lys Lys Asp Trp Glu 210 215
220Thr Ser Pro Lys Ala Asp Ala Ile Lys Lys Val Ile Ala Ala Tyr
His225 230 235 240Thr Asp Asp Val Lys Lys Val Ile Glu Glu Ser Ser
Asp Gly Leu Asp 245 250 255Gln Pro Val Trp 26033640DNAStreptococcus
pneumoniae 33ttcgaaaggg tcagaaggtg cagaccttat cagcatgaaa ggggatgtca
ttacagaaca 60tcaattttat gagcaagtga aaagcaaccc ttcagcccaa caagtcttgt
taaatatgac 120catccaaaaa gtttttgaaa aacaatatgg ctcagagctt
gatgataaag aggttgatga 180tactattgcc gaagaaaaaa aacaatatgg
cgaaaactac caacgtgtct tgtcacaagc 240aggtatgact cttgaaacac
gtaaagctca aattcgtaca agtaaattag ttgagttggc 300agttaagaag
gtagcagaag ctgaattgac agatgaagcc tataagaaag cctttgatga
360gtacactcca gatgtaacgg ctcaaatcat ccgtcttaat aatgaagata
aggccaaaga 420agttctcgaa aaagccaagg cagaaggtgc tgattttgct
caattagcca aagataattc 480aactgatgaa aaaacaaaag aaaatggtgg
agaaattacc tttgattctg cttcaacaga 540agtacctgga gcaagtccaa
aaaagccgct tttcgctttt agatgtggga tggtgtttct 600ggatgtggat
tacagcaact ggggcacacc aagcctacag 64034213PRTStreptococcus
pneumoniae 34Ser Lys Gly Ser Glu Gly Ala Asp Leu Ile Ser Met Lys
Gly Asp Val1 5 10 15Ile Thr Glu His Gln Phe Tyr Glu Gln Val Lys Ser
Asn Pro Ser Ala 20 25 30Gln Gln Val Leu Leu Asn Met Thr Ile Gln Lys
Val Phe Glu Lys Gln 35 40 45Tyr Gly Ser Glu Leu Asp Asp Lys Glu Val
Asp Asp Thr Ile Ala Glu 50 55 60Glu Lys Lys Gln Tyr Gly Glu Asn Tyr
Gln Arg Val Leu Ser Gln Ala65 70 75 80Gly Met Thr Leu Glu Thr Arg
Lys Ala Gln Ile Arg Thr Ser Lys Leu 85 90 95Val Glu Leu Ala Val Lys
Lys Val Ala Glu Ala Glu Leu Thr Asp Glu 100 105 110Ala Tyr Lys Lys
Ala Phe Asp Glu Tyr Thr Pro Asp Val Thr Ala Gln 115 120 125Ile Ile
Arg Leu Asn Asn Glu Asp Lys Ala Lys Glu Val Leu Glu Lys 130 135
140Ala Lys Ala Glu Gly Ala Asp Phe Ala Gln Leu Ala Lys Asp Asn
Ser145 150 155 160Thr Asp Glu Lys Thr Lys Glu Asn Gly Gly Glu Ile
Thr Phe Asp Ser 165 170 175Ala Ser Thr Glu Val Pro Gly Ala Ser Pro
Lys Lys Pro Leu Phe Ala 180 185 190Phe Arg Cys Gly Met Val Phe Leu
Asp Val Asp Tyr Ser Asn Trp Gly 195 200 205Thr Pro Ser Leu Gln
21035631DNAStreptococcus pneumoniae 35ggggatggca gcttttaaaa
atcctaacaa tcaatacaaa gctattacaa ttgctcaaac 60tctaggtgat gatgcttctt
cagaggaatt ggctggtaga tatggttctg ctgttcagtg 120tacagaagtg
actgcctcaa acctttcaac agttaaaact aaagctacgg ttgtagaaaa
180accactgaaa gattttagag cgtctacgtc tgatcagtct ggttgggtgg
aatctaatgg 240taaatggtat ttctatgagt ctggtgatgt gaagacaggt
tgggtgaaaa cagatggtaa 300atggtactat ttgaatgact taggtgtcat
gcagactgga tttgtaaaat tttctggtag 360ctggtattac ttgagcaatt
caggtgctat gtttacaggc tggggaacag atggtagcag 420atggttctac
tttgacggct caggagctat gaagacaggc tggtacaagg aaaatggcac
480ttggtattac cttgacgaag caggtatcat gaagacaggt tggtttaaag
tcggaccaca 540ctggtactat gcctacggtt caggagcttt ggctgtgagc
acaacaacac cagatggtta 600ccgtgtaaat ggtaatggtg aatgggtaaa c
63136210PRTStreptococcus pneumoniae 36Gly Met Ala Ala Phe Lys Asn
Pro Asn Asn Gln Tyr Lys Ala Ile Thr1 5 10 15Ile Ala Gln Thr Leu Gly
Asp Asp Ala Ser Ser Glu Glu Leu Ala Gly 20 25 30Arg Tyr Gly Ser Ala
Val Gln Cys Thr Glu Val Thr Ala Ser Asn Leu 35 40 45Ser Thr Val Lys
Thr Lys Ala Thr Val Val Glu Lys Pro Leu Lys Asp 50 55 60Phe Arg Ala
Ser Thr Ser Asp Gln Ser Gly Trp Val Glu Ser Asn Gly65 70 75 80Lys
Trp Tyr Phe Tyr Glu Ser Gly Asp Val Lys Thr Gly Trp Val Lys 85 90
95Thr Asp Gly Lys Trp Tyr Tyr Leu Asn Asp Leu Gly Val Met Gln Thr
100 105 110Gly Phe Val Lys Phe Ser Gly Ser Trp Tyr Tyr Leu Ser Asn
Ser Gly 115 120 125Ala Met Phe Thr Gly Trp Gly Thr Asp Gly Ser Arg
Trp Phe Tyr Phe 130 135 140Asp Gly Ser Gly Ala Met Lys Thr Gly Trp
Tyr Lys Glu Asn Gly Thr145 150 155 160Trp Tyr Tyr Leu Asp Glu Ala
Gly Ile Met Lys Thr Gly Trp Phe Lys 165 170 175Val Gly Pro His Trp
Tyr Tyr Ala Tyr Gly Ser Gly Ala Leu Ala Val 180 185 190Ser Thr Thr
Thr Pro Asp Gly Tyr Arg Val Asn Gly Asn Gly Glu Trp 195 200 205Val
Asn 210371360DNAStreptococcus pneumoniae 37agacgagcaa aaaattaagc
aagcagaagc ggaagttgag agtaaacaag ctgaggctac 60aaggttaaaa aaaatcaaga
cagatcgtga agaagcagaa gaagaagcta aacgaagagc 120agatgctaaa
gagcaaggta aaccaaaggg gcgggcaaaa cgaggagttc ctggagagct
180agcaacacct gataaaaaag aaaatgatgc gaagtcttca gattctagcg
taggtgaaga 240aactcttcca agcccatccc tgaaaccaga aaaaaaggta
gcagaagctg agaagaaggt 300tgaagaagct aagaaaaaag ccgaggatca
aaaagaagaa gatcgccgta actacccaac 360caatacttac aaaacgcttg
aacttgaaat tgctgagtcc gatgtggaag ttaaaaaagc 420ggagcttgaa
ctagtaaaag aggaagctaa ggaacctcga aacgaggaaa aagttaagca
480agcaaaagcg gaagttgaga gtaaaaaagc tgaggctaca aggttagaaa
aaatcaagac 540agatcgtaaa aaagcagaag aagaagctaa acgaaaagca
gcagaagaag ataaagttaa 600agaaaaacca gctgaacaac cacaaccagc
gccggctcca aaagcagaaa aaccagctcc 660agctccaaaa ccagagaatc
cagctgaaca accaaaagca gaaaaaccag ctgatcaaca 720agctgaagaa
gactatgctc gtagatcaga agaagaatat aatcgcttga ctcaacagca
780accgccaaaa actgaaaaac cagcacaacc atctactcca aaaacaggct
ggaaacaaga 840aaacggtatg tggtacttct acaatactga tggttcaatg
gcgacaggat ggctccaaaa 900caatggctca tggtactacc tcaacagcaa
tggcgctatg gcgacaggat ggctccaaaa 960caatggttca tggtactatc
taaacgctaa tggttcaatg gcaacaggat ggctccaaaa 1020caatggttca
tggtactacc taaacgctaa tggttcaatg gcgacaggat ggctccaata
1080caatggctca tggtactacc taaacgctaa tggttcaatg gcgacaggat
ggctccaata 1140caatggctca tggtactacc taaacgctaa tggtgatatg
gcgacaggtt gggtgaaaga 1200tggagatacc tggtactatc ttgaagcatc
aggtgctatg aaagcaagcc aatggttcaa 1260agtatcagat aaatggtact
atgtcaatgg ctcaggtgcc cttgcagtca acacaactgt 1320agatggctat
ggagtcaatg ccaatggtga atgggtaaac 136038453PRTStreptococcus
pneumoniae 38Asp Glu Gln Lys Ile Lys Gln Ala Glu Ala Glu Val Glu
Ser Lys Gln1 5 10 15Ala Glu Ala Thr Arg Leu Lys Lys Ile Lys Thr Asp
Arg Glu Glu Ala 20 25 30Glu Glu Glu Ala Lys Arg Arg Ala Asp Ala Lys
Glu Gln Gly Lys Pro 35 40 45Lys Gly Arg Ala Lys Arg Gly Val Pro Gly
Glu Leu Ala Thr Pro Asp 50 55 60Lys Lys Glu Asn Asp Ala Lys Ser Ser
Asp Ser Ser Val Gly Glu Glu65 70 75 80Thr Leu Pro Ser Pro Ser Leu
Lys Pro Glu Lys Lys Val Ala Glu Ala 85 90 95Glu Lys Lys Val Glu Glu
Ala Lys Lys Lys Ala Glu Asp Gln Lys Glu 100 105 110Glu Asp Arg Arg
Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu Glu Leu 115 120 125Glu Ile
Ala Glu Ser Asp Val Glu Val Lys Lys Ala Glu Leu Glu Leu
130 135 140Val Lys Glu Glu Ala Lys Glu Pro Arg Asn Glu Glu Lys Val
Lys Gln145 150 155 160Ala Lys Ala Glu Val Glu Ser Lys Lys Ala Glu
Ala Thr Arg Leu Glu 165 170 175Lys Ile Lys Thr Asp Arg Lys Lys Ala
Glu Glu Glu Ala Lys Arg Lys 180 185 190Ala Ala Glu Glu Asp Lys Val
Lys Glu Lys Pro Ala Glu Gln Pro Gln 195 200 205Pro Ala Pro Ala Pro
Lys Ala Glu Lys Pro Ala Pro Ala Pro Lys Pro 210 215 220Glu Asn Pro
Ala Glu Gln Pro Lys Ala Glu Lys Pro Ala Asp Gln Gln225 230 235
240Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu
245 250 255Thr Gln Gln Gln Pro Pro Lys Thr Glu Lys Pro Ala Gln Pro
Ser Thr 260 265 270Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp
Tyr Phe Tyr Asn 275 280 285Thr Asp Gly Ser Met Ala Thr Gly Trp Leu
Gln Asn Asn Gly Ser Trp 290 295 300Tyr Tyr Leu Asn Ser Asn Gly Ala
Met Ala Thr Gly Trp Leu Gln Asn305 310 315 320Asn Gly Ser Trp Tyr
Tyr Leu Asn Ala Asn Gly Ser Met Ala Thr Gly 325 330 335Trp Leu Gln
Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser 340 345 350Met
Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn 355 360
365Ala Asn Gly Ser Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp
370 375 380Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Val
Lys Asp385 390 395 400Gly Asp Thr Trp Tyr Tyr Leu Glu Ala Ser Gly
Ala Met Lys Ala Ser 405 410 415Gln Trp Phe Lys Val Ser Asp Lys Trp
Tyr Tyr Val Asn Gly Ser Gly 420 425 430Ala Leu Ala Val Asn Thr Thr
Val Asp Gly Tyr Gly Val Asn Ala Asn 435 440 445Gly Glu Trp Val Asn
45039412DNAStreptococcus pneumoniae 39ctgtggtgag gaagaaacta
aaaagactca agcagcacaa cagccaaaac aacaaacgac 60tgtacaacaa attgctgttg
gaaaagatgc tccagacttc acattgcaat ccatggatgg 120caaagaagtt
aagttatctg attttaaggg taaaaaggtt tacttgaagt tttgggcttc
180atggtgtggt ccatgcaaga aaagtatgcc agagttgatg gaactagcgg
cgaaaccaga 240tcgtgatttc gaaattctta ctgtcattgc accaggaatt
caaggtgaaa aaactgttga 300gcaattccca caatggttcc aggaacaagg
atataaggat atcccagttc tttatgatac 360caaagcaacc acttccaagc
ttatcaaatt cgaagcattc ctacagaata tt 41240137PRTStreptococcus
pneumoniae 40Cys Gly Glu Glu Glu Thr Lys Lys Thr Gln Ala Ala Gln
Gln Pro Lys1 5 10 15Gln Gln Thr Thr Val Gln Gln Ile Ala Val Gly Lys
Asp Ala Pro Asp 20 25 30Phe Thr Leu Gln Ser Met Asp Gly Lys Glu Val
Lys Leu Ser Asp Phe 35 40 45Lys Gly Lys Lys Val Tyr Leu Lys Phe Trp
Ala Ser Trp Cys Gly Pro 50 55 60Cys Lys Lys Ser Met Pro Glu Leu Met
Glu Leu Ala Ala Lys Pro Asp65 70 75 80Arg Asp Phe Glu Ile Leu Thr
Val Ile Ala Pro Gly Ile Gln Gly Glu 85 90 95Lys Thr Val Glu Gln Phe
Pro Gln Trp Phe Gln Glu Gln Gly Tyr Lys 100 105 110Asp Ile Pro Val
Leu Tyr Asp Thr Lys Ala Thr Thr Ser Lys Leu Ile 115 120 125Lys Phe
Glu Ala Phe Leu Gln Asn Ile 130 135411462DNAStreptococcus
pneumoniae 41gacttttaac aataaaacta ttgaagagtt gcacaatctc cttgtctcta
aggaaatttc 60tgcaacagaa ttgacccaag caacacttga aaatatcaag tctcgtgagg
aagccctcaa 120ttcatttgtc accatcgctg aggagcaagc tcttgttcaa
gctaaagcca ttgatgaagc 180tggaattgat gctgacaatg tcctttcagg
aattccactt gctgttaagg ataacatctc 240tacagacggt attctcacaa
ctgctgcctc aaaaatgctc tacaactatg agccaatctt 300tgatgcgaca
gctgttgcca atgcaaaaac caagggcatg attgtcgttg gaaagaccaa
360catggacgaa tttgctatgg gtggttcagg tgaaacttca cactacggag
caactaaaaa 420cgcttggaac cacagcaagg ttcctggtgg gtcatcaagt
ggttctgccg cagctgtagc 480ctcaggacaa gttcgcttgt cacttggttc
tgatactggt ggttccatcc gccaacctgc 540tgccttcaac ggaatcgttg
gtctcaaacc aacctacgga acagtttcac gtttcggtct 600cattgccttt
ggtagctcat tagaccagat tggacctttt gctcctactg ttaaggaaaa
660tgccctcttg ctcaacgcta ttgccagcga agatgctaaa gactctactt
ctgctcctgt 720ccgcatcgcc gactttactt caaaaatcgg ccaagacatc
aagggtatga aaatcgcttt 780gcctaaggaa tacctaggcg aaggaattga
tccagaggtt aaggaaacaa tcttaaacgc 840ggccaaacac tttgaaaaat
tgggtgctat cgtcgaagaa gtcagccttc ctcactctaa 900atacggtgtt
gccgtttatt acatcatcgc ttcatcagaa gcttcatcaa acttgcaacg
960cttcgacggt atccgttacg gctatcgcgc agaagatgca accaaccttg
atgaaatcta 1020tgtaaacagc cgaagccaag gttttggtga agaggtaaaa
cgtcgtatca tgctgggtac 1080tttcagtctt tcatcaggtt actatgatgc
ctactacaaa aaggctggtc aagtccgtac 1140cctcatcatt caagatttcg
aaaaagtctt cgcggattac gatttgattt tgggtccaac 1200tgctccaagt
gttgcctatg acttggattc tctcaaccat gacccagttg ccatgtactt
1260agccgaccta ttgaccatac ctgtaaactt ggcaggactg cctggaattt
cgattcctgc 1320tggattctct caaggtctac ctgtcggact ccaattgatt
ggtcccaagt actctgagga 1380aaccatttac caagctgctg ctgcttttga
agcaacaaca gactaccaca aacaacaacc 1440cgtgattttt ggaggtgaca ac
146242487PRTStreptococcus pneumoniae 42Thr Phe Asn Asn Lys Thr Ile
Glu Glu Leu His Asn Leu Leu Val Ser1 5 10 15Lys Glu Ile Ser Ala Thr
Glu Leu Thr Gln Ala Thr Leu Glu Asn Ile 20 25 30Lys Ser Arg Glu Glu
Ala Leu Asn Ser Phe Val Thr Ile Ala Glu Glu 35 40 45Gln Ala Leu Val
Gln Ala Lys Ala Ile Asp Glu Ala Gly Ile Asp Ala 50 55 60Asp Asn Val
Leu Ser Gly Ile Pro Leu Ala Val Lys Asp Asn Ile Ser65 70 75 80Thr
Asp Gly Ile Leu Thr Thr Ala Ala Ser Lys Met Leu Tyr Asn Tyr 85 90
95Glu Pro Ile Phe Asp Ala Thr Ala Val Ala Asn Ala Lys Thr Lys Gly
100 105 110Met Ile Val Val Gly Lys Thr Asn Met Asp Glu Phe Ala Met
Gly Gly 115 120 125Ser Gly Glu Thr Ser His Tyr Gly Ala Thr Lys Asn
Ala Trp Asn His 130 135 140Ser Lys Val Pro Gly Gly Ser Ser Ser Gly
Ser Ala Ala Ala Val Ala145 150 155 160Ser Gly Gln Val Arg Leu Ser
Leu Gly Ser Asp Thr Gly Gly Ser Ile 165 170 175Arg Gln Pro Ala Ala
Phe Asn Gly Ile Val Gly Leu Lys Pro Thr Tyr 180 185 190Gly Thr Val
Ser Arg Phe Gly Leu Ile Ala Phe Gly Ser Ser Leu Asp 195 200 205Gln
Ile Gly Pro Phe Ala Pro Thr Val Lys Glu Asn Ala Leu Leu Leu 210 215
220Asn Ala Ile Ala Ser Glu Asp Ala Lys Asp Ser Thr Ser Ala Pro
Val225 230 235 240Arg Ile Ala Asp Phe Thr Ser Lys Ile Gly Gln Asp
Ile Lys Gly Met 245 250 255Lys Ile Ala Leu Pro Lys Glu Tyr Leu Gly
Glu Gly Ile Asp Pro Glu 260 265 270Val Lys Glu Thr Ile Leu Asn Ala
Ala Lys His Phe Glu Lys Leu Gly 275 280 285Ala Ile Val Glu Glu Val
Ser Leu Pro His Ser Lys Tyr Gly Val Ala 290 295 300Val Tyr Tyr Ile
Ile Ala Ser Ser Glu Ala Ser Ser Asn Leu Gln Arg305 310 315 320Phe
Asp Gly Ile Arg Tyr Gly Tyr Arg Ala Glu Asp Ala Thr Asn Leu 325 330
335Asp Glu Ile Tyr Val Asn Ser Arg Ser Gln Gly Phe Gly Glu Glu Val
340 345 350Lys Arg Arg Ile Met Leu Gly Thr Phe Ser Leu Ser Ser Gly
Tyr Tyr 355 360 365Asp Ala Tyr Tyr Lys Lys Ala Gly Gln Val Arg Thr
Leu Ile Ile Gln 370 375 380Asp Phe Glu Lys Val Phe Ala Asp Tyr Asp
Leu Ile Leu Gly Pro Thr385 390 395 400Ala Pro Ser Val Ala Tyr Asp
Leu Asp Ser Leu Asn His Asp Pro Val 405 410 415Ala Met Tyr Leu Ala
Asp Leu Leu Thr Ile Pro Val Asn Leu Ala Gly 420 425 430Leu Pro Gly
Ile Ser Ile Pro Ala Gly Phe Ser Gln Gly Leu Pro Val 435 440 445Gly
Leu Gln Leu Ile Gly Pro Lys Tyr Ser Glu Glu Thr Ile Tyr Gln 450 455
460Ala Ala Ala Ala Phe Glu Ala Thr Thr Asp Tyr His Lys Gln Gln
Pro465 470 475 480Val Ile Phe Gly Gly Asp Asn
48543433DNAStreptococcus pneumoniae 43ctttacaggt aaacaactac
aagtcggcga caaggcgctt gatttttctc ttactacaac 60agatctttct aaaaaatctc
tggctgattt tgatggcaag aaaaaagtct tgagtgtcgt 120tccttctatc
gatacaggca tctgctcaac tcaaacacgt cgttttaatg aagaattggc
180tggactggac aacacggtcg tattgactgt ttcaatggac ctaccttttg
ctcaaaaacg 240ttggtgcggt gctgaaggcc ttgacaatgc cattatgctt
tcagactact ttgaccattc 300tttcgggcgc gattatgccc tcttgatcaa
cgaatggcac ctattagcac gcgcagtctt 360tgtcctcgat actgacaata
cgattcgcta cgttgaatac gtggataata tcaattctga 420gccaaacttc gaa
43344144PRTStreptococcus pneumoniae 44Phe Thr Gly Lys Gln Leu Gln
Val Gly Asp Lys Ala Leu Asp Phe Ser1 5 10 15Leu Thr Thr Thr Asp Leu
Ser Lys Lys Ser Leu Ala Asp Phe Asp Gly 20 25 30Lys Lys Lys Val Leu
Ser Val Val Pro Ser Ile Asp Thr Gly Ile Cys 35 40 45Ser Thr Gln Thr
Arg Arg Phe Asn Glu Glu Leu Ala Gly Leu Asp Asn 50 55 60Thr Val Val
Leu Thr Val Ser Met Asp Leu Pro Phe Ala Gln Lys Arg65 70 75 80Trp
Cys Gly Ala Glu Gly Leu Asp Asn Ala Ile Met Leu Ser Asp Tyr 85 90
95Phe Asp His Ser Phe Gly Arg Asp Tyr Ala Leu Leu Ile Asn Glu Trp
100 105 110His Leu Leu Ala Arg Ala Val Phe Val Leu Asp Thr Asp Asn
Thr Ile 115 120 125Arg Tyr Val Glu Tyr Val Asp Asn Ile Asn Ser Glu
Pro Asn Phe Glu 130 135 14045724DNAStreptococcus
pneumoniaemisc_feature(88)..(88)n is a, c, g, or t 45ccaggctgat
acaagtatcg cagacattca aaaaagaggc gaactggttg tcggtgtcaa 60acaagacgtt
cccaattttg gttacaanga tcccaagacc ggtacttatt ctggtatcga
120aaccgacttg gccaagatgg tagctgatga actcaaggtc aagattcgct
atgtgccggt 180tacagcacaa acccgcggcc cccttctaga caatgaacag
gtcgatatgg atatcgcgac 240ctttaccatc acggacgaac gcaaaaaact
ctacaacttt accagtccct actacacaga 300cgcttctgga tttttggtca
ataaatctgc caaaatcaaa aagattgagg acctaaacgg 360caaaaccatc
ggagtcgccc aaggttctat cacccaacgc ctgattactg aactgggtaa
420aaagaaaggt ctgaagttta aattcgtcga acttggttcc tacccagaat
tgattacttc 480cctgcacgct catcgtatcg ataccttttc cgttgaccgc
tctattctat ctggctacac 540tagtaaacgg acagcactac tagatgatag
tttcaagcca tctgactacg gtattgttac 600caagaaatca aatacagagc
tcaacgacta tcttgataac ttggttacta aatggagcaa 660ggatggtagt
ttgcagaaac tttatgaccg ttacaagctc aaaccatcta gccatactgc 720agat
72446241PRTStreptococcus pneumoniaeSITE(29)..(29)Xaa can be any
naturally occurring amino acid 46Gln Ala Asp Thr Ser Ile Ala Asp
Ile Gln Lys Arg Gly Glu Leu Val1 5 10 15Val Gly Val Lys Gln Asp Val
Pro Asn Phe Gly Tyr Xaa Asp Pro Lys 20 25 30Thr Gly Thr Tyr Ser Gly
Ile Glu Thr Asp Leu Ala Lys Met Val Ala 35 40 45Asp Glu Leu Lys Val
Lys Ile Arg Tyr Val Pro Val Thr Ala Gln Thr 50 55 60Arg Gly Pro Leu
Leu Asp Asn Glu Gln Val Asp Met Asp Ile Ala Thr65 70 75 80Phe Thr
Ile Thr Asp Glu Arg Lys Lys Leu Tyr Asn Phe Thr Ser Pro 85 90 95Tyr
Tyr Thr Asp Ala Ser Gly Phe Leu Val Asn Lys Ser Ala Lys Ile 100 105
110Lys Lys Ile Glu Asp Leu Asn Gly Lys Thr Ile Gly Val Ala Gln Gly
115 120 125Ser Ile Thr Gln Arg Leu Ile Thr Glu Leu Gly Lys Lys Lys
Gly Leu 130 135 140Lys Phe Lys Phe Val Glu Leu Gly Ser Tyr Pro Glu
Leu Ile Thr Ser145 150 155 160Leu His Ala His Arg Ile Asp Thr Phe
Ser Val Asp Arg Ser Ile Leu 165 170 175Ser Gly Tyr Thr Ser Lys Arg
Thr Ala Leu Leu Asp Asp Ser Phe Lys 180 185 190Pro Ser Asp Tyr Gly
Ile Val Thr Lys Lys Ser Asn Thr Glu Leu Asn 195 200 205Asp Tyr Leu
Asp Asn Leu Val Thr Lys Trp Ser Lys Asp Gly Ser Leu 210 215 220Gln
Lys Leu Tyr Asp Arg Tyr Lys Leu Lys Pro Ser Ser His Thr Ala225 230
235 240Asp471279DNAStreptococcus pneumoniae 47gtctgtatca tttgaaaaca
aagaaacaaa ccgtggtgtc ttgactttca ctatctctca 60agaccaaatc aaaccagaat
tggaccgtgt cttcaagtca gtgaagaaat ctcttaatgt 120tccaggtttc
cgtaaaggtc accttccacg ccctatcttc gaccaaaaat ttggtgaaga
180agctctttat caagatgcaa tgaacgcact tttgccaaac gcttatgaag
cagctgtaaa 240agaagctggt cttgaagtgg ttgcccaacc aaaaattgac
gtaacttcaa tggaaaaagg 300tcaagactgg gttatcactg ctgaagtcgt
tacaaaacct gaagtaaaat tgggtgacta 360caaaaacctt gaagtatcag
ttgatgtaga aaaagaagta actgacgctg atgtcgaaga 420gcgtatcgaa
cgcgaacgca acaacctggc tgaattggtt atcaaggaag ctgctgctga
480aaacggcgac actgttgtga tcgacttcgt tggttctatc gacggtgttg
aatttgacgg 540tggaaaaggt gaaaacttct cacttggact tggttcaggt
caattcatcc ctggtttcga 600agaccaattg gtaggtcact cagctggcga
aaccgttgat gttatcgtaa cattcccaga 660agactaccaa gcagaagacc
ttgcaggtaa agaagctaaa ttcgtgacaa ctatccacga 720agtaaaagct
aaagaagttc cggctcttga cgatgaactt gcaaaagaca ttgatgaaga
780agttgaaaca cttgctgact tgaaagaaaa atacagcaaa gaattggctg
ctgctaaaga 840agaagcttac aaagatgcag ttgaaggtgc agcaattgat
acagctgtag aaaatgctga 900aatcgtagaa cttccagaag aaatgatcca
tgaagaagtt caccgttcag taaatgaatt 960ccttgggaat ttgcaacgtc
aagggatcaa ccctgacatg tacttccaaa tcactggaac 1020tactcaagaa
gaccttcaca accaatacca agcagaagct gagtcacgta ctaagactaa
1080ccttgttatc gaagcagttg ccaaagctga aggatttgat gcttcagaag
aagaaatcca 1140aaaagaagtt gagcaattgg cagcagacta caacatggaa
gttgcacaag ttcaaaactt 1200gctttcagct gacatgttga aacatgatat
cactatcaaa aaagctgttg aattgatcac 1260aagcacagca acagtaaaa
127948426PRTStreptococcus pneumoniae 48Ser Val Ser Phe Glu Asn Lys
Glu Thr Asn Arg Gly Val Leu Thr Phe1 5 10 15Thr Ile Ser Gln Asp Gln
Ile Lys Pro Glu Leu Asp Arg Val Phe Lys 20 25 30Ser Val Lys Lys Ser
Leu Asn Val Pro Gly Phe Arg Lys Gly His Leu 35 40 45Pro Arg Pro Ile
Phe Asp Gln Lys Phe Gly Glu Glu Ala Leu Tyr Gln 50 55 60Asp Ala Met
Asn Ala Leu Leu Pro Asn Ala Tyr Glu Ala Ala Val Lys65 70 75 80Glu
Ala Gly Leu Glu Val Val Ala Gln Pro Lys Ile Asp Val Thr Ser 85 90
95Met Glu Lys Gly Gln Asp Trp Val Ile Thr Ala Glu Val Val Thr Lys
100 105 110Pro Glu Val Lys Leu Gly Asp Tyr Lys Asn Leu Glu Val Ser
Val Asp 115 120 125Val Glu Lys Glu Val Thr Asp Ala Asp Val Glu Glu
Arg Ile Glu Arg 130 135 140Glu Arg Asn Asn Leu Ala Glu Leu Val Ile
Lys Glu Ala Ala Ala Glu145 150 155 160Asn Gly Asp Thr Val Val Ile
Asp Phe Val Gly Ser Ile Asp Gly Val 165 170 175Glu Phe Asp Gly Gly
Lys Gly Glu Asn Phe Ser Leu Gly Leu Gly Ser 180 185 190Gly Gln Phe
Ile Pro Gly Phe Glu Asp Gln Leu Val Gly His Ser Ala 195 200 205Gly
Glu Thr Val Asp Val Ile Val Thr Phe Pro Glu Asp Tyr Gln Ala 210 215
220Glu Asp Leu Ala Gly Lys Glu Ala Lys Phe Val Thr Thr Ile His
Glu225 230 235 240Val Lys Ala Lys Glu Val Pro Ala Leu Asp Asp Glu
Leu Ala Lys Asp 245 250 255Ile Asp Glu Glu Val Glu Thr Leu Ala Asp
Leu Lys Glu Lys Tyr Ser 260 265 270Lys Glu Leu Ala Ala Ala Lys Glu
Glu Ala Tyr Lys Asp Ala Val Glu 275 280 285Gly Ala Ala Ile Asp Thr
Ala Val Glu Asn Ala Glu Ile Val Glu Leu 290 295 300Pro Glu Glu Met
Ile His Glu Glu Val His Arg Ser Val Asn Glu Phe305 310 315 320Leu
Gly Asn Leu Gln Arg Gln Gly Ile Asn Pro Asp Met Tyr Phe Gln 325 330
335Ile Thr Gly Thr Thr Gln Glu Asp Leu His Asn Gln Tyr Gln Ala Glu
340
345 350Ala Glu Ser Arg Thr Lys Thr Asn Leu Val Ile Glu Ala Val Ala
Lys 355 360 365Ala Glu Gly Phe Asp Ala Ser Glu Glu Glu Ile Gln Lys
Glu Val Glu 370 375 380Gln Leu Ala Ala Asp Tyr Asn Met Glu Val Ala
Gln Val Gln Asn Leu385 390 395 400Leu Ser Ala Asp Met Leu Lys His
Asp Ile Thr Ile Lys Lys Ala Val 405 410 415Glu Leu Ile Thr Ser Thr
Ala Thr Val Lys 420 42549490DNAStreptococcus pneumoniae
49tggtcaaaag gaaagtcaga caggaaaggg gatgaaaatt gtgaccagtt tttatcctat
60ctacgctatg gttaaggaag tatctggtga cttgaatgat gttcggatga ttcagtcaag
120tagtggtatt cactcctttg aaccttcggc aaatgatatc gcagccatct
atgatgcaga 180tgtctttgtt taccattctc atacactcga atcttgggca
ggaagtctgg atccaaatct 240aaaaaaatcc aaagtgaagg tcttagaggc
ttctgaggga atgaccttgg aacgtgtccc 300tggactagag gatgtggaag
caggggatgg agttgatgaa aaaacgctct atgaccctca 360cacatggcta
gatcctgaaa aagctggaga agaagcccaa attatcgctg ataaactttc
420agaggtggat agtgagcata aagagactta tcaaaaaaat gcgcaacctt
tatcaaaaaa 480gctcaggaat 49050163PRTStreptococcus pneumoniae 50Gly
Gln Lys Glu Ser Gln Thr Gly Lys Gly Met Lys Ile Val Thr Ser1 5 10
15Phe Tyr Pro Ile Tyr Ala Met Val Lys Glu Val Ser Gly Asp Leu Asn
20 25 30Asp Val Arg Met Ile Gln Ser Ser Ser Gly Ile His Ser Phe Glu
Pro 35 40 45Ser Ala Asn Asp Ile Ala Ala Ile Tyr Asp Ala Asp Val Phe
Val Tyr 50 55 60His Ser His Thr Leu Glu Ser Trp Ala Gly Ser Leu Asp
Pro Asn Leu65 70 75 80Lys Lys Ser Lys Val Lys Val Leu Glu Ala Ser
Glu Gly Met Thr Leu 85 90 95Glu Arg Val Pro Gly Leu Glu Asp Val Glu
Ala Gly Asp Gly Val Asp 100 105 110Glu Lys Thr Leu Tyr Asp Pro His
Thr Trp Leu Asp Pro Glu Lys Ala 115 120 125Gly Glu Glu Ala Gln Ile
Ile Ala Asp Lys Leu Ser Glu Val Asp Ser 130 135 140Glu His Lys Glu
Thr Tyr Gln Lys Asn Ala Gln Pro Leu Ser Lys Lys145 150 155 160Leu
Arg Asn511006DNAStreptococcus pneumoniaemisc_feature(935)..(935)n
is a, c, g, or t 51gaaggataga tatattttag catttgagac atcctgtgat
gagaccagtg tcgccgtctt 60gaaaaacgac gatgagctct tgtccaatgt cattgctagt
caaattgaga gtcacaaacg 120ttttggtggc gtagtgcccg aagtagccag
tcgtcaccat gtcgaggtca ttacagcctg 180tatcgaggag gcattggcag
aagcagggat taccgaagag gacgtgacag ctgttgcggt 240tacctacgga
ccaggcttgg tcggagcctt gctagttggt ttgtcagctg ccaaggcctt
300tgcttgggct cacggacttc cactgattcc tgttaatcac atggctgggc
acctcatggc 360agctcagagt gtggagcctt tggagtttcc cttgctagcc
ctcttggtca gcggcggaca 420cacagagttg gtttatgttt cggaggcagg
agattataag attgttgggg aaacccgtga 480tgatgcggtt ggtgaggctt
atgataaggt cggccgtgtc atgggcttga cctatcctgc 540aggtcgtgag
attgacgagc tggctcatca ggggcaggat atttatgatt tcccccgtgc
600catgattaag gaagataatc tggagttctc cttctcaggt ttgaaatctg
cctttatcaa 660tcttcatcac aatgccgagc aaaagggaga aagcctgtct
acagaagatt tgtgtgcttc 720cttccaagca gcagttatgg acattctcat
ggcaaaaacc aagaaggctt tggagaaata 780tcctgttaaa atcctagttg
tggcaggtgg tgtggcagcc aataaaggtc tcagagaacg 840cctagcagcc
gaaatcacag atgtcaaggt tatcatcccc cctctgcgac tctgcggaga
900caatgcaggt atgattgcct atgccagcgt cagcnagtgg aacaaagaaa
acttcgcagg 960ctgggacctc aatgccaaac caagtcttgc ctttgatacc atggaa
100652335PRTStreptococcus pneumoniaeSITE(312)..(312)Xaa can be any
naturally occurring amino acid 52Lys Asp Arg Tyr Ile Leu Ala Phe
Glu Thr Ser Cys Asp Glu Thr Ser1 5 10 15Val Ala Val Leu Lys Asn Asp
Asp Glu Leu Leu Ser Asn Val Ile Ala 20 25 30Ser Gln Ile Glu Ser His
Lys Arg Phe Gly Gly Val Val Pro Glu Val 35 40 45Ala Ser Arg His His
Val Glu Val Ile Thr Ala Cys Ile Glu Glu Ala 50 55 60Leu Ala Glu Ala
Gly Ile Thr Glu Glu Asp Val Thr Ala Val Ala Val65 70 75 80Thr Tyr
Gly Pro Gly Leu Val Gly Ala Leu Leu Val Gly Leu Ser Ala 85 90 95Ala
Lys Ala Phe Ala Trp Ala His Gly Leu Pro Leu Ile Pro Val Asn 100 105
110His Met Ala Gly His Leu Met Ala Ala Gln Ser Val Glu Pro Leu Glu
115 120 125Phe Pro Leu Leu Ala Leu Leu Val Ser Gly Gly His Thr Glu
Leu Val 130 135 140Tyr Val Ser Glu Ala Gly Asp Tyr Lys Ile Val Gly
Glu Thr Arg Asp145 150 155 160Asp Ala Val Gly Glu Ala Tyr Asp Lys
Val Gly Arg Val Met Gly Leu 165 170 175Thr Tyr Pro Ala Gly Arg Glu
Ile Asp Glu Leu Ala His Gln Gly Gln 180 185 190Asp Ile Tyr Asp Phe
Pro Arg Ala Met Ile Lys Glu Asp Asn Leu Glu 195 200 205Phe Ser Phe
Ser Gly Leu Lys Ser Ala Phe Ile Asn Leu His His Asn 210 215 220Ala
Glu Gln Lys Gly Glu Ser Leu Ser Thr Glu Asp Leu Cys Ala Ser225 230
235 240Phe Gln Ala Ala Val Met Asp Ile Leu Met Ala Lys Thr Lys Lys
Ala 245 250 255Leu Glu Lys Tyr Pro Val Lys Ile Leu Val Val Ala Gly
Gly Val Ala 260 265 270Ala Asn Lys Gly Leu Arg Glu Arg Leu Ala Ala
Glu Ile Thr Asp Val 275 280 285Lys Val Ile Ile Pro Pro Leu Arg Leu
Cys Gly Asp Asn Ala Gly Met 290 295 300Ile Ala Tyr Ala Ser Val Ser
Xaa Trp Asn Lys Glu Asn Phe Ala Gly305 310 315 320Trp Asp Leu Asn
Ala Lys Pro Ser Leu Ala Phe Asp Thr Met Glu 325 330
335531000DNAStreptococcus pneumoniae 53ggtagttaaa gttggtatta
acggtttcgg acgtatcggt cgtcttgctt tccgtcgtat 60ccaaaacgta gaaggtgttg
aagttacacg catcaacgac cttacagatc cagttatgct 120tgcacacttg
ttgaaatacg acacaactca aggtcgtttc gacggtactg ttgaagttaa
180agaaggtgga tttgaagtta acggtaaatt catcaaagtt tctgctgaac
gtgatccaga 240acaaatcgac tgggctactg acggtgtaga aatcgttctt
gaagctactg gtttctttgc 300taagaaagaa gcagctgaaa aacaccttaa
aggtggagct aaaaaagttg ttatcactgc 360tcctggtgga aacgacgtta
aaacagttgt attcaacact aaccacgacg ttcttgacgg 420tactgaaaca
gttatctcag gtgcttcatg tactacaaac tgcttggctc caatggctaa
480agctcttcaa gacaactttg gtgttgttga aggattgatg actactatcc
acgcttacac 540tggtgaccaa atgatccttg acggaccaca ccgtggtggt
gaccttcgcc gtgctcgcgc 600tggtgctgca aacatcgttc ctaactcaac
tggtgctgca aaagctatcg gtcttgtaat 660cccagaattg aatggtaaac
ttgacggatc tgcacaacgc gttccaactc caactggatc 720agttactgaa
ttggtagcag ttcttgaaaa gaacgttact gttgatgaag tgaacgcagc
780tatgaaagca gcttcaaacg aatcatacgg ttacacagaa gatccaatcg
tatcttcaga 840tatcgtaggt atgtcttacg gttcattgtt tgacgcaact
caaactaaag ttcttgacgt 900tgacggtaaa caattggtta aagttgtatc
atggtacgac aacgaaatgt catacactgc 960acaacttgtt cgtactcttg
gaatacttcg caaaaattgc 100054333PRTStreptococcus pneumoniae 54Val
Val Lys Val Gly Ile Asn Gly Phe Gly Arg Ile Gly Arg Leu Ala1 5 10
15Phe Arg Arg Ile Gln Asn Val Glu Gly Val Glu Val Thr Arg Ile Asn
20 25 30Asp Leu Thr Asp Pro Val Met Leu Ala His Leu Leu Lys Tyr Asp
Thr 35 40 45Thr Gln Gly Arg Phe Asp Gly Thr Val Glu Val Lys Glu Gly
Gly Phe 50 55 60Glu Val Asn Gly Lys Phe Ile Lys Val Ser Ala Glu Arg
Asp Pro Glu65 70 75 80Gln Ile Asp Trp Ala Thr Asp Gly Val Glu Ile
Val Leu Glu Ala Thr 85 90 95Gly Phe Phe Ala Lys Lys Glu Ala Ala Glu
Lys His Leu Lys Gly Gly 100 105 110Ala Lys Lys Val Val Ile Thr Ala
Pro Gly Gly Asn Asp Val Lys Thr 115 120 125Val Val Phe Asn Thr Asn
His Asp Val Leu Asp Gly Thr Glu Thr Val 130 135 140Ile Ser Gly Ala
Ser Cys Thr Thr Asn Cys Leu Ala Pro Met Ala Lys145 150 155 160Ala
Leu Gln Asp Asn Phe Gly Val Val Glu Gly Leu Met Thr Thr Ile 165 170
175His Ala Tyr Thr Gly Asp Gln Met Ile Leu Asp Gly Pro His Arg Gly
180 185 190Gly Asp Leu Arg Arg Ala Arg Ala Gly Ala Ala Asn Ile Val
Pro Asn 195 200 205Ser Thr Gly Ala Ala Lys Ala Ile Gly Leu Val Ile
Pro Glu Leu Asn 210 215 220Gly Lys Leu Asp Gly Ser Ala Gln Arg Val
Pro Thr Pro Thr Gly Ser225 230 235 240Val Thr Glu Leu Val Ala Val
Leu Glu Lys Asn Val Thr Val Asp Glu 245 250 255Val Asn Ala Ala Met
Lys Ala Ala Ser Asn Glu Ser Tyr Gly Tyr Thr 260 265 270Glu Asp Pro
Ile Val Ser Ser Asp Ile Val Gly Met Ser Tyr Gly Ser 275 280 285Leu
Phe Asp Ala Thr Gln Thr Lys Val Leu Asp Val Asp Gly Lys Gln 290 295
300Leu Val Lys Val Val Ser Trp Tyr Asp Asn Glu Met Ser Tyr Thr
Ala305 310 315 320Gln Leu Val Arg Thr Leu Gly Ile Leu Arg Lys Asn
Cys 325 330552389DNAStreptococcus
pneumoniaemisc_feature(1368)..(1368)n is a, c, g, or t 55ttcttacgag
ttgggactgt atcaagctag aacggttaag gaaaataatc gtgtttccta 60tatagatgga
aaacaagcga cgcaaaaaac ggagaatttg actcctgatg aggttagcaa
120gcgtgaagga atcaatgctg agcaaatcgt catcaagata acagaccaag
gctatgtcac 180ttcacatggc gaccactatc attattacaa tggtaaggtt
ccttatgacg ctatcatcag 240tgaagaatta ctcatgaaag atccaaacta
taagctaaaa gatgaggata ttgttaatga 300ggtcaagggt ggatatgtta
tcaaggtaga tggaaaatac tatgtttacc ttaaggatgc 360tgcccacgcg
gataacgtcc gtacaaaaga ggaaatcaat cgacaaaaac aagagcatag
420tcaacatcgt gaaggtggaa ctccaagaaa cgatggtgct gttgccttgg
cacgttcgca 480aggacgctat actacagatg atggttatat ctttaatgct
tctgatatca tagaggatac 540tggtgatgct tatatcgttc ctcatggaga
tcattaccat tacattccta agaatgagtt 600atcagctagc gagttggctg
ctgcagaagc cttcctatct ggtcgaggaa atctgtcaaa 660ttcaagaacc
tatcgccgac aaaatagcga taacacttca agaacaaact gggtaccttc
720tgtaagcaat ccaggaacta caaatactaa cacaagcaac aacagcaaca
ctaacagtca 780agcaagtcaa agtaatgaca ttgatagtct cttgaaacag
ctctacaaac tgcctttgag 840tcaacgacat gtagaatctg atggccttgt
ctttgatcca gcacaaatca caagtcgaac 900agctagaggt gttgcagtgc
cacacggaga tcattaccac ttcatccctt actctcaaat 960gtctgaattg
gaagaacgaa tcgctcgtat tattcccctt cgttatcgtt caaaccattg
1020ggtaccagat tcaaggccag aacaaccaag tccacaaccg actccggaac
ctagtccagg 1080cccgcaacct gcaccaaatc ttaaaataga ctcaaattct
tctttggtta gtcagctggt 1140acgaaaagtt ggggaaggat atgtattcga
agaaaagggc atctctcgtt atgtctttgc 1200gaaagattta ccatctgaaa
ctgttaaaaa tcttgaaagc aagttatcaa aacaagagag 1260tgtttcacac
actttaactg ctaaaaaaga aaatgttgct cctcgtgacc aagaatttta
1320tgataaagca tataatctgt taactgaggc tcataaagcc ttgtttgnaa
ataagggtcg 1380taattctgat ttccaagcct tagacaaatt attagaacgc
ttgaatgatg aatcgactaa 1440taaagaaaaa ttggtagatg atttattggc
attcctagca ccaattaccc atccagagcg 1500acttggcaaa ccaaattctc
aaattgagta tactgaagac gaagttcgta ttgctcaatt 1560agctgataag
tatacaacgt cagatggtta catttttgat gaacatgata taatcagtga
1620tgaaggagat gcatatgtaa cgcctcatat gggccatagt cactggattg
gaaaagatag 1680cctttctgat aaggaaaaag ttgcagctca agcctatact
aaagaaaaag gtatcctacc 1740tccatctcca gacgcagatg ttaaagcaaa
tccaactgga gatagtgcag cagctattta 1800caatcgtgtg aaaggggaaa
aacgaattcc actcgttcga cttccatata tggttgagca 1860tacagttgag
gttaaaaacg gtaatttgat tattcctcat aaggatcatt accataatat
1920taaatttgct tggtttgatg atcacacata caaagctcca aatggctata
ccttggaaga 1980tttgtttgcg acgattaagt actacgtaga acaccctgac
gaacgtccac attctaatga 2040tggatggggc aatgccagtg agcatgtgtt
aggcaagaaa gaccacagtg aagatccaaa 2100taagaacttc aaagcggatg
aagagccagt agaggaaaca cctgctgagc cagaagtccc 2160tcaagtagag
actgaaaaag tagaagccca actcaaagaa gcagaagttt tgcttgcgaa
2220agtaacggat tctagtctga aagccaatgc aacagaaact ctagctggtt
tacgaaataa 2280tttgactctt caaattatgg ataacaatag tatcatggca
gaagcagaaa aattacttgc 2340gttgttaaaa ggaagtaatc cttcatctgt
aagtaaggaa aaaataaac 238956796PRTStreptococcus
pneumoniaeSITE(456)..(456)Xaa can be any naturally occurring amino
acid 56Ser Tyr Glu Leu Gly Leu Tyr Gln Ala Arg Thr Val Lys Glu Asn
Asn1 5 10 15Arg Val Ser Tyr Ile Asp Gly Lys Gln Ala Thr Gln Lys Thr
Glu Asn 20 25 30Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly Ile Asn
Ala Glu Gln 35 40 45Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val Thr
Ser His Gly Asp 50 55 60His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr
Asp Ala Ile Ile Ser65 70 75 80Glu Glu Leu Leu Met Lys Asp Pro Asn
Tyr Lys Leu Lys Asp Glu Asp 85 90 95Ile Val Asn Glu Val Lys Gly Gly
Tyr Val Ile Lys Val Asp Gly Lys 100 105 110Tyr Tyr Val Tyr Leu Lys
Asp Ala Ala His Ala Asp Asn Val Arg Thr 115 120 125Lys Glu Glu Ile
Asn Arg Gln Lys Gln Glu His Ser Gln His Arg Glu 130 135 140Gly Gly
Thr Pro Arg Asn Asp Gly Ala Val Ala Leu Ala Arg Ser Gln145 150 155
160Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser Asp Ile
165 170 175Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp
His Tyr 180 185 190His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu
Leu Ala Ala Ala 195 200 205Glu Ala Phe Leu Ser Gly Arg Gly Asn Leu
Ser Asn Ser Arg Thr Tyr 210 215 220Arg Arg Gln Asn Ser Asp Asn Thr
Ser Arg Thr Asn Trp Val Pro Ser225 230 235 240Val Ser Asn Pro Gly
Thr Thr Asn Thr Asn Thr Ser Asn Asn Ser Asn 245 250 255Thr Asn Ser
Gln Ala Ser Gln Ser Asn Asp Ile Asp Ser Leu Leu Lys 260 265 270Gln
Leu Tyr Lys Leu Pro Leu Ser Gln Arg His Val Glu Ser Asp Gly 275 280
285Leu Val Phe Asp Pro Ala Gln Ile Thr Ser Arg Thr Ala Arg Gly Val
290 295 300Ala Val Pro His Gly Asp His Tyr His Phe Ile Pro Tyr Ser
Gln Met305 310 315 320Ser Glu Leu Glu Glu Arg Ile Ala Arg Ile Ile
Pro Leu Arg Tyr Arg 325 330 335Ser Asn His Trp Val Pro Asp Ser Arg
Pro Glu Gln Pro Ser Pro Gln 340 345 350Pro Thr Pro Glu Pro Ser Pro
Gly Pro Gln Pro Ala Pro Asn Leu Lys 355 360 365Ile Asp Ser Asn Ser
Ser Leu Val Ser Gln Leu Val Arg Lys Val Gly 370 375 380Glu Gly Tyr
Val Phe Glu Glu Lys Gly Ile Ser Arg Tyr Val Phe Ala385 390 395
400Lys Asp Leu Pro Ser Glu Thr Val Lys Asn Leu Glu Ser Lys Leu Ser
405 410 415Lys Gln Glu Ser Val Ser His Thr Leu Thr Ala Lys Lys Glu
Asn Val 420 425 430Ala Pro Arg Asp Gln Glu Phe Tyr Asp Lys Ala Tyr
Asn Leu Leu Thr 435 440 445Glu Ala His Lys Ala Leu Phe Xaa Asn Lys
Gly Arg Asn Ser Asp Phe 450 455 460Gln Ala Leu Asp Lys Leu Leu Glu
Arg Leu Asn Asp Glu Ser Thr Asn465 470 475 480Lys Glu Lys Leu Val
Asp Asp Leu Leu Ala Phe Leu Ala Pro Ile Thr 485 490 495His Pro Glu
Arg Leu Gly Lys Pro Asn Ser Gln Ile Glu Tyr Thr Glu 500 505 510Asp
Glu Val Arg Ile Ala Gln Leu Ala Asp Lys Tyr Thr Thr Ser Asp 515 520
525Gly Tyr Ile Phe Asp Glu His Asp Ile Ile Ser Asp Glu Gly Asp Ala
530 535 540Tyr Val Thr Pro His Met Gly His Ser His Trp Ile Gly Lys
Asp Ser545 550 555 560Leu Ser Asp Lys Glu Lys Val Ala Ala Gln Ala
Tyr Thr Lys Glu Lys 565 570 575Gly Ile Leu Pro Pro Ser Pro Asp Ala
Asp Val Lys Ala Asn Pro Thr 580 585 590Gly Asp Ser Ala Ala Ala Ile
Tyr Asn Arg Val Lys Gly Glu Lys Arg 595 600 605Ile Pro Leu Val Arg
Leu Pro Tyr Met Val Glu His Thr Val Glu Val 610 615 620Lys Asn Gly
Asn Leu Ile Ile Pro His Lys Asp His Tyr His Asn Ile625 630 635
640Lys Phe Ala Trp Phe Asp Asp His Thr Tyr Lys Ala Pro Asn Gly Tyr
645 650 655Thr Leu Glu Asp Leu Phe Ala Thr Ile Lys Tyr Tyr Val Glu
His Pro 660 665 670Asp Glu Arg Pro His Ser
Asn Asp Gly Trp Gly Asn Ala Ser Glu His 675 680 685Val Leu Gly Lys
Lys Asp His Ser Glu Asp Pro Asn Lys Asn Phe Lys 690 695 700Ala Asp
Glu Glu Pro Val Glu Glu Thr Pro Ala Glu Pro Glu Val Pro705 710 715
720Gln Val Glu Thr Glu Lys Val Glu Ala Gln Leu Lys Glu Ala Glu Val
725 730 735Leu Leu Ala Lys Val Thr Asp Ser Ser Leu Lys Ala Asn Ala
Thr Glu 740 745 750Thr Leu Ala Gly Leu Arg Asn Asn Leu Thr Leu Gln
Ile Met Asp Asn 755 760 765Asn Ser Ile Met Ala Glu Ala Glu Lys Leu
Leu Ala Leu Leu Lys Gly 770 775 780Ser Asn Pro Ser Ser Val Ser Lys
Glu Lys Ile Asn785 790 795571180DNAStreptococcus
pneumoniaemisc_feature(819)..(820)n is a, c, g, or t 57tactgagatg
catcataatc taggagctga aaagcgttca gcagtggcta ctactatcga 60tagttttaag
gagcgaagtc aaaaagtcag agcactatct gatccaaatg tgcgttttgt
120tcccttcttt ggctctagtg aatggcttcg ttttgacggt gctcattctg
cggtattagc 180tgagaaatac aatcgttcct accgtcctta tcttttagga
caggggggag ctgcatcgct 240taaccaatat tttggaatgc aacagatgtt
accacagctg gagaataaac aagttgtgta 300tgttatctca cctcagtggt
tcagtaaaaa tggctatgat ccagcagcct tccagcagta 360ttttaatgga
gaccagttga ctagttttct gaaacatcaa tctggggatc aggctagtca
420atatgcagcg actcgcttac tgcaacagtt cccaaacgta gctatgaagg
acctggttca 480gaagttggca agtaaagaag aattgtcgac agcagacaat
gaaatgattg aattattggc 540tcgttttaat gaacgccaag cttccttttt
tggtcagttt tcggttagag gctatgttaa 600ctacgataag catgtagcta
agtatttaaa aatcttgcca gaccagtttt cttatcaggc 660aatagaagat
gttgtcaaag cagatgctga aaaaaatact tccaataatg agatgggaat
720ggaaaattat ttctataatg agcagatcaa gaaggatttg aagaaattaa
aggattctca 780gaaaagcttt acctatctca agtcgccaga gtataatgnn
ttgcagttgg ttttaacaca 840gttttctaaa tctaaggtaa acccgatttt
tatcattcca cctgttaata aaaaatggat 900gnactatgct ggtctacgag
aggatatgta ccaacaaacg gtgcagaaga ttcgctacca 960gttagaaagt
caaggtttta ccaatatagc agatttttct aaggacggcg gggagccttt
1020ctttatgaag gacaccattc accttggttg gttgggttgg ttggcttttg
acaaggcagt 1080tgatcctttc ctatccaatc ccacaccagc tccgacttac
catctgaatg agcgcttttt 1140cagcaaagat tgggcgactt atgatggaga
tgtcaaagaa 118058393PRTStreptococcus pneumoniaeSITE(273)..(273)Xaa
can be any naturally occurring amino acid 58Thr Glu Met His His Asn
Leu Gly Ala Glu Lys Arg Ser Ala Val Ala1 5 10 15Thr Thr Ile Asp Ser
Phe Lys Glu Arg Ser Gln Lys Val Arg Ala Leu 20 25 30Ser Asp Pro Asn
Val Arg Phe Val Pro Phe Phe Gly Ser Ser Glu Trp 35 40 45Leu Arg Phe
Asp Gly Ala His Ser Ala Val Leu Ala Glu Lys Tyr Asn 50 55 60Arg Ser
Tyr Arg Pro Tyr Leu Leu Gly Gln Gly Gly Ala Ala Ser Leu65 70 75
80Asn Gln Tyr Phe Gly Met Gln Gln Met Leu Pro Gln Leu Glu Asn Lys
85 90 95Gln Val Val Tyr Val Ile Ser Pro Gln Trp Phe Ser Lys Asn Gly
Tyr 100 105 110Asp Pro Ala Ala Phe Gln Gln Tyr Phe Asn Gly Asp Gln
Leu Thr Ser 115 120 125Phe Leu Lys His Gln Ser Gly Asp Gln Ala Ser
Gln Tyr Ala Ala Thr 130 135 140Arg Leu Leu Gln Gln Phe Pro Asn Val
Ala Met Lys Asp Leu Val Gln145 150 155 160Lys Leu Ala Ser Lys Glu
Glu Leu Ser Thr Ala Asp Asn Glu Met Ile 165 170 175Glu Leu Leu Ala
Arg Phe Asn Glu Arg Gln Ala Ser Phe Phe Gly Gln 180 185 190Phe Ser
Val Arg Gly Tyr Val Asn Tyr Asp Lys His Val Ala Lys Tyr 195 200
205Leu Lys Ile Leu Pro Asp Gln Phe Ser Tyr Gln Ala Ile Glu Asp Val
210 215 220Val Lys Ala Asp Ala Glu Lys Asn Thr Ser Asn Asn Glu Met
Gly Met225 230 235 240Glu Asn Tyr Phe Tyr Asn Glu Gln Ile Lys Lys
Asp Leu Lys Lys Leu 245 250 255Lys Asp Ser Gln Lys Ser Phe Thr Tyr
Leu Lys Ser Pro Glu Tyr Asn 260 265 270Xaa Leu Gln Leu Val Leu Thr
Gln Phe Ser Lys Ser Lys Val Asn Pro 275 280 285Ile Phe Ile Ile Pro
Pro Val Asn Lys Lys Trp Met Xaa Tyr Ala Gly 290 295 300Leu Arg Glu
Asp Met Tyr Gln Gln Thr Val Gln Lys Ile Arg Tyr Gln305 310 315
320Leu Glu Ser Gln Gly Phe Thr Asn Ile Ala Asp Phe Ser Lys Asp Gly
325 330 335Gly Glu Pro Phe Phe Met Lys Asp Thr Ile His Leu Gly Trp
Leu Gly 340 345 350Trp Leu Ala Phe Asp Lys Ala Val Asp Pro Phe Leu
Ser Asn Pro Thr 355 360 365Pro Ala Pro Thr Tyr His Leu Asn Glu Arg
Phe Phe Ser Lys Asp Trp 370 375 380Ala Thr Tyr Asp Gly Asp Val Lys
Glu385 390591423DNAStreptococcus pneumoniae 59ggttttgaga aagtatttgc
agggggccct gattgagtcg attgagcaag tggaaaatga 60ccgtattgtg gaaattacag
tttccaataa aaacgagatt ggagaccata tccaggctac 120cttgattatc
gaaattatgg ggaaacacag taatattcta ctggtcgata aaagcagtca
180taaaatcctc gaagttatca aacacgtcgg cttttcacaa aatagctacc
gcaccttact 240tccaggatcg acctatatcg ctccgccaag tacaaaatct
ctcaatcctt ttactatcaa 300ggatgaaaag ctctttgaaa tcctgcaaac
ccaagaacta acagcaaaaa atcttcaaag 360cctctttcaa ggtctgggac
gcgatacggc aaatgaattg gaaaggatac tggttagtga 420aaaactttcc
gctttccgaa attttttcaa tcaagaaacc aagccatgct tgactgagac
480ttccttcagt ccagttcctt ttgcaaatca ggtgggagag ccttttgcaa
atctttctga 540tttgttggac acctactata aggataaggc tgagcgcgac
cgcgtcaaac agcaggccag 600tgaactgatt cgtcgtgttg aaaatgaact
tcagaaaaac cgacacaaac tcaaaaaaca 660ggaaaaagag ttactggcga
cagacaacgc tgaagaattt cgtcaaaaag gagaattgct 720gacaaccttc
ctccaccaag tgcctaacga ccaagaccag gttatcctag acaactacta
780taccaaccaa cctatcatga ttgcgcttga taaggctctg actcccaacc
agaatgccca 840acgctatttt aaacggtatc agaaactcaa agaagctgtc
aaatacttga ctgatttgat 900tgaagaaacc aaagccacta ttctctatct
ggaaagtgta gaaaccgtcc tcaaccaagc 960tggactggaa gaaatcgctg
aaatccgtga agaattgatt caaacaggtt ttatccgcag 1020aagacaacgg
gagaaaatcc agaaacgcaa aaaactagaa caatatctag caagcgatgg
1080caaaaccatc atctatgtcg gacgaaacaa tcttcaaaat gaggaattga
cctttaaaat 1140ggcccgcaag gaggaacttt ggttccatgc taaggacatt
cctggaagcc atgttgtcat 1200ctcaggaaat cttgacccat ctgatgcagt
caagacagac gcagcagagt tagctgccta 1260cttctctcaa gggcgcctgt
cgaatctggt gcaggtagat atgattgaag tcaaaaaact 1320caataaacca
actggtggaa aacccggctt tgtcacttac acaggacaaa agaccctccg
1380cgtcacacca gactccaaaa aaattgcatc catgaaaaaa tcc
142360474PRTStreptococcus pneumoniae 60Val Leu Arg Lys Tyr Leu Gln
Gly Ala Leu Ile Glu Ser Ile Glu Gln1 5 10 15Val Glu Asn Asp Arg Ile
Val Glu Ile Thr Val Ser Asn Lys Asn Glu 20 25 30Ile Gly Asp His Ile
Gln Ala Thr Leu Ile Ile Glu Ile Met Gly Lys 35 40 45His Ser Asn Ile
Leu Leu Val Asp Lys Ser Ser His Lys Ile Leu Glu 50 55 60Val Ile Lys
His Val Gly Phe Ser Gln Asn Ser Tyr Arg Thr Leu Leu65 70 75 80Pro
Gly Ser Thr Tyr Ile Ala Pro Pro Ser Thr Lys Ser Leu Asn Pro 85 90
95Phe Thr Ile Lys Asp Glu Lys Leu Phe Glu Ile Leu Gln Thr Gln Glu
100 105 110Leu Thr Ala Lys Asn Leu Gln Ser Leu Phe Gln Gly Leu Gly
Arg Asp 115 120 125Thr Ala Asn Glu Leu Glu Arg Ile Leu Val Ser Glu
Lys Leu Ser Ala 130 135 140Phe Arg Asn Phe Phe Asn Gln Glu Thr Lys
Pro Cys Leu Thr Glu Thr145 150 155 160Ser Phe Ser Pro Val Pro Phe
Ala Asn Gln Val Gly Glu Pro Phe Ala 165 170 175Asn Leu Ser Asp Leu
Leu Asp Thr Tyr Tyr Lys Asp Lys Ala Glu Arg 180 185 190Asp Arg Val
Lys Gln Gln Ala Ser Glu Leu Ile Arg Arg Val Glu Asn 195 200 205Glu
Leu Gln Lys Asn Arg His Lys Leu Lys Lys Gln Glu Lys Glu Leu 210 215
220Leu Ala Thr Asp Asn Ala Glu Glu Phe Arg Gln Lys Gly Glu Leu
Leu225 230 235 240Thr Thr Phe Leu His Gln Val Pro Asn Asp Gln Asp
Gln Val Ile Leu 245 250 255Asp Asn Tyr Tyr Thr Asn Gln Pro Ile Met
Ile Ala Leu Asp Lys Ala 260 265 270Leu Thr Pro Asn Gln Asn Ala Gln
Arg Tyr Phe Lys Arg Tyr Gln Lys 275 280 285Leu Lys Glu Ala Val Lys
Tyr Leu Thr Asp Leu Ile Glu Glu Thr Lys 290 295 300Ala Thr Ile Leu
Tyr Leu Glu Ser Val Glu Thr Val Leu Asn Gln Ala305 310 315 320Gly
Leu Glu Glu Ile Ala Glu Ile Arg Glu Glu Leu Ile Gln Thr Gly 325 330
335Phe Ile Arg Arg Arg Gln Arg Glu Lys Ile Gln Lys Arg Lys Lys Leu
340 345 350Glu Gln Tyr Leu Ala Ser Asp Gly Lys Thr Ile Ile Tyr Val
Gly Arg 355 360 365Asn Asn Leu Gln Asn Glu Glu Leu Thr Phe Lys Met
Ala Arg Lys Glu 370 375 380Glu Leu Trp Phe His Ala Lys Asp Ile Pro
Gly Ser His Val Val Ile385 390 395 400Ser Gly Asn Leu Asp Pro Ser
Asp Ala Val Lys Thr Asp Ala Ala Glu 405 410 415Leu Ala Ala Tyr Phe
Ser Gln Gly Arg Leu Ser Asn Leu Val Gln Val 420 425 430Asp Met Ile
Glu Val Lys Lys Leu Asn Lys Pro Thr Gly Gly Lys Pro 435 440 445Gly
Phe Val Thr Tyr Thr Gly Gln Lys Thr Leu Arg Val Thr Pro Asp 450 455
460Ser Lys Lys Ile Ala Ser Met Lys Lys Ser465
47061544DNAStreptococcus pneumoniae 61gacaacattt actatccata
cagtagagtc agcaccagca gaagtgaaag aaattcttga 60aacagtagaa aaagacaaca
atggctatat tcccaaccta atcggtctct tggccaatgc 120cccgactgtt
ttagaagcct accaaattgt ctcatctatc caccgtcgca acagcctgac
180acccgttgag cgtgaagtgg tgcaaatcac ggcagccgtg accaatggtt
gtgccttctg 240tgtcgcaggt cacacagcct tttccatcaa acaaatccag
atgaatgatg acttgattca 300agctcttcgc aatcgtactc caattgaaac
agatcctaaa ttggataccc tagctaagtt 360taccttggca gttatcaata
ccaagggtcg tgtaggagat gaagccttgt ctgagttttt 420agaagctggc
tacactcaac aaaatgcctt ggatgtggtt tttggtgtca gcctagcaat
480cctctgtaac tatgccaaca acttagctaa tacaccaatt aatccagaat
tgcaacctta 540tgcc 54462181PRTStreptococcus pneumoniae 62Thr Thr
Phe Thr Ile His Thr Val Glu Ser Ala Pro Ala Glu Val Lys1 5 10 15Glu
Ile Leu Glu Thr Val Glu Lys Asp Asn Asn Gly Tyr Ile Pro Asn 20 25
30Leu Ile Gly Leu Leu Ala Asn Ala Pro Thr Val Leu Glu Ala Tyr Gln
35 40 45Ile Val Ser Ser Ile His Arg Arg Asn Ser Leu Thr Pro Val Glu
Arg 50 55 60Glu Val Val Gln Ile Thr Ala Ala Val Thr Asn Gly Cys Ala
Phe Cys65 70 75 80Val Ala Gly His Thr Ala Phe Ser Ile Lys Gln Ile
Gln Met Asn Asp 85 90 95Asp Leu Ile Gln Ala Leu Arg Asn Arg Thr Pro
Ile Glu Thr Asp Pro 100 105 110Lys Leu Asp Thr Leu Ala Lys Phe Thr
Leu Ala Val Ile Asn Thr Lys 115 120 125Gly Arg Val Gly Asp Glu Ala
Leu Ser Glu Phe Leu Glu Ala Gly Tyr 130 135 140Thr Gln Gln Asn Ala
Leu Asp Val Val Phe Gly Val Ser Leu Ala Ile145 150 155 160Leu Cys
Asn Tyr Ala Asn Asn Leu Ala Asn Thr Pro Ile Asn Pro Glu 165 170
175Leu Gln Pro Tyr Ala 18063811DNAStreptococcus pneumoniae
63ggctaaggaa agagtggatg tactagctta taaacagggg ttgtttgaaa cgagagagca
60ggccaagcga ggtgtgatgg ctggcctagt cgtagcagtc cttaatggag aacggtttga
120caagccagga gagaaaattc cagatgacac cgaattaaaa ctcaaggggg
agaaactcaa 180gtatgtcagc cgtggtggtt tgaaactgga aaaggccttg
caggtctttg atttgtcggt 240ggatggcgcg actacgattg atatcggggc
ctctactgga ggttttaccg atgtcatgct 300acagaatagt gccaagttgg
tctttgcagt cgatgttggt accaatcagt tggcttggaa 360attacgccaa
gacccacgag ttgtcagcat ggagcagttc aatttccgct atgctgaaaa
420gactgatttc gagcaggagc cgagctttgc cagtattgat gtgagtttca
tttcccttag 480tctgattttg ccagccttgc accgtgtctt ggctgatcaa
ggtcaggtgg tagcacttgt 540caaacctcag tttgaggcag gacgtgagca
gattgggaaa aatggaatta ttcgagatgc 600taaggttcat cagaatgtcc
ttgaatctgt aacagctatg gcagtagagg taggtttttc 660agtccttggc
ttggactttt ctcccatcca aggtggacat ggaaatattg aatttttagc
720gtatttgaaa aaagaaaagt cagcaagcaa tcagattctt gctgagatta
aagaagcagt 780agagagggcg catagtcaat ttaaaaatga a
81164270PRTStreptococcus pneumoniae 64Ala Lys Glu Arg Val Asp Val
Leu Ala Tyr Lys Gln Gly Leu Phe Glu1 5 10 15Thr Arg Glu Gln Ala Lys
Arg Gly Val Met Ala Gly Leu Val Val Ala 20 25 30Val Leu Asn Gly Glu
Arg Phe Asp Lys Pro Gly Glu Lys Ile Pro Asp 35 40 45Asp Thr Glu Leu
Lys Leu Lys Gly Glu Lys Leu Lys Tyr Val Ser Arg 50 55 60Gly Gly Leu
Lys Leu Glu Lys Ala Leu Gln Val Phe Asp Leu Ser Val65 70 75 80Asp
Gly Ala Thr Thr Ile Asp Ile Gly Ala Ser Thr Gly Gly Phe Thr 85 90
95Asp Val Met Leu Gln Asn Ser Ala Lys Leu Val Phe Ala Val Asp Val
100 105 110Gly Thr Asn Gln Leu Ala Trp Lys Leu Arg Gln Asp Pro Arg
Val Val 115 120 125Ser Met Glu Gln Phe Asn Phe Arg Tyr Ala Glu Lys
Thr Asp Phe Glu 130 135 140Gln Glu Pro Ser Phe Ala Ser Ile Asp Val
Ser Phe Ile Ser Leu Ser145 150 155 160Leu Ile Leu Pro Ala Leu His
Arg Val Leu Ala Asp Gln Gly Gln Val 165 170 175Val Ala Leu Val Lys
Pro Gln Phe Glu Ala Gly Arg Glu Gln Ile Gly 180 185 190Lys Asn Gly
Ile Ile Arg Asp Ala Lys Val His Gln Asn Val Leu Glu 195 200 205Ser
Val Thr Ala Met Ala Val Glu Val Gly Phe Ser Val Leu Gly Leu 210 215
220Asp Phe Ser Pro Ile Gln Gly Gly His Gly Asn Ile Glu Phe Leu
Ala225 230 235 240Tyr Leu Lys Lys Glu Lys Ser Ala Ser Asn Gln Ile
Leu Ala Glu Ile 245 250 255Lys Glu Ala Val Glu Arg Ala His Ser Gln
Phe Lys Asn Glu 260 265 270652290DNAStreptococcus
pneumoniaemisc_feature(154)..(154)n is a, c, g, or t 65ttgttcctat
gaacttggtc gtcaccaagc tggtcaggtt aagaaagagt ctaatcgagt 60ttcttatata
gatggtgatc aggctggtca aaaggcagaa aacttgacac cagatgaagt
120cagtaagagg gaggggatca acgccgaaca aatngtnatc aagattacgg
atcaaggtta 180tgtgacctct catggagacc attatcatta ctataatggc
aaggttcctt atgatgccat 240catcagtgaa gagctcctca tgaaagatcc
gaattatcag ttgaaggatt cagacattgt 300caatgaaatc aagggtggtt
atgtcattaa ggtaaacggt aaatactatg tntaccttaa 360ggatgcagct
catgcggata atattcggac aaaagaagag attaaacgtc agaagcagga
420acgcagtcat aatcataact caagagcaga taatgctgtt gctgcagcca
gagcccaagg 480acgttataca acggatgatg ggtatatctt caatgcatct
gatatcattg aggacacggg 540tgatgcttat atcgttcctc acggcgacca
ttaccattac attcctaaga atgagttatc 600agctagcgag ttagctgctg
cagaagccta ttggaatggg aagcagggat ctcgtccttc 660ttcaagttct
agttataatg caaatccagc tcaaccaaga ttgtcagaga accacaatct
720gactgtcact ccaacttatc atcaaaatca aggggaaaac atttcaagcc
ttttacgtga 780attgtatgct aaacccttat cagaacgcca tgtggaatct
gatggcctta ttttcgaccc 840agcgcaaatc acaagtcgaa ccgccagagg
tgtagctgtc cctcatggta accattacca 900ctttatccct tatgaacaaa
tgtctgaatt ggaaaaacga attgctcgta ttattcccct 960tcgttatcgt
tcaaaccatt gggtaccaga ttcaagacca gaacaaccaa gtccacaatc
1020gactccggaa cctagtccaa gtccgcaacc tgcaccaaat cctcaaccag
ctccaagcaa 1080tccaattgat gagaaattgg tcaaagaagc tgttcgaaaa
gtaggcgatg gttatgtctt 1140tgaggagaat ggagtttctc gttatatccc
agccaaggat ctttcagcag aaacagcagc 1200aggcattgat agcaaactgg
ccaagcagga aagtttatct cataagctag gagctaagaa 1260aactgacctc
ccatctagtg atcgagaatt ttacaataag gcttatgact tactagcaag
1320aattcaccaa gatttacttg ataataaagg tcgacaagtt gattttgagg
ctttggataa 1380cctgttggaa cgactcaagg atgtcncaag tgataaagtc
aagttagtgg angatattct 1440tgccttctta gctccgattc gtcatccaga
acgtttagga aaaccaaatg cgcaaattac 1500ctacactgat gatgagattc
aagtagccaa gttggcaggc aagtacacaa cagaagacgg 1560ttatatcttt
gatcctcgtg atataaccag tgatgagggg gatgcctatg taactccaca
1620tatgacccat agccactgga ttaaaaaaga tagtttgtct gaagctgaga
gagcggcagc 1680ccaggcttat gctaaagaga aaggtttgac ccctccttcg
acagaccatc aggattcagg 1740aaatactgag gcaaaaggag cagaagctat
ctacaaccgc gtgaaagcag ctaagaaggt 1800gccacttgat cgtatgcctt
acaatcttca atatactgta gaagtcaaaa acggtagttt
1860aatcatacct cattatgacc attaccataa catcaaattt gagtggtttg
acgaaggcct 1920ttatgaggca cctaaggggt atactcttga ggatcttttg
gcgactgtca agtactatgt 1980cgaacatcca aacgaacgtc cgcattcaga
taatggtttt ggtaacgcta gcgaccatgt 2040tcaaagaaac aaaaatggtc
aagctgatac caatcaaacg gaaaaaccaa gcgaggagaa 2100acctcagaca
gaaaaacctg aggaagaaac ccctcgagaa gagaaaccgc aaagcgagaa
2160accagagtct ccaaaaccaa cagaggaacc agaagaatca ccagaggaat
cagaagaacc 2220tcaggtcgag actgaaaagg ttgaagaaaa actgagagag
gctgaagatt tacttggaaa 2280aatccaggat 229066763PRTStreptococcus
pneumoniaeSITE(51)..(51)Xaa can be any naturally occurring amino
acid 66Cys Ser Tyr Glu Leu Gly Arg His Gln Ala Gly Gln Val Lys Lys
Glu1 5 10 15Ser Asn Arg Val Ser Tyr Ile Asp Gly Asp Gln Ala Gly Gln
Lys Ala 20 25 30Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly
Ile Asn Ala 35 40 45Glu Gln Xaa Val Ile Lys Ile Thr Asp Gln Gly Tyr
Val Thr Ser His 50 55 60Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val
Pro Tyr Asp Ala Ile65 70 75 80Ile Ser Glu Glu Leu Leu Met Lys Asp
Pro Asn Tyr Gln Leu Lys Asp 85 90 95Ser Asp Ile Val Asn Glu Ile Lys
Gly Gly Tyr Val Ile Lys Val Asn 100 105 110Gly Lys Tyr Tyr Val Tyr
Leu Lys Asp Ala Ala His Ala Asp Asn Ile 115 120 125Arg Thr Lys Glu
Glu Ile Lys Arg Gln Lys Gln Glu Arg Ser His Asn 130 135 140His Asn
Ser Arg Ala Asp Asn Ala Val Ala Ala Ala Arg Ala Gln Gly145 150 155
160Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser Asp Ile Ile
165 170 175Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp His
Tyr His 180 185 190Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu
Ala Ala Ala Glu 195 200 205Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg
Pro Ser Ser Ser Ser Ser 210 215 220Tyr Asn Ala Asn Pro Ala Gln Pro
Arg Leu Ser Glu Asn His Asn Leu225 230 235 240Thr Val Thr Pro Thr
Tyr His Gln Asn Gln Gly Glu Asn Ile Ser Ser 245 250 255Leu Leu Arg
Glu Leu Tyr Ala Lys Pro Leu Ser Glu Arg His Val Glu 260 265 270Ser
Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr Ser Arg Thr Ala 275 280
285Arg Gly Val Ala Val Pro His Gly Asn His Tyr His Phe Ile Pro Tyr
290 295 300Glu Gln Met Ser Glu Leu Glu Lys Arg Ile Ala Arg Ile Ile
Pro Leu305 310 315 320Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser
Arg Pro Glu Gln Pro 325 330 335Ser Pro Gln Ser Thr Pro Glu Pro Ser
Pro Ser Pro Gln Pro Ala Pro 340 345 350Asn Pro Gln Pro Ala Pro Ser
Asn Pro Ile Asp Glu Lys Leu Val Lys 355 360 365Glu Ala Val Arg Lys
Val Gly Asp Gly Tyr Val Phe Glu Glu Asn Gly 370 375 380Val Ser Arg
Tyr Ile Pro Ala Lys Asp Leu Ser Ala Glu Thr Ala Ala385 390 395
400Gly Ile Asp Ser Lys Leu Ala Lys Gln Glu Ser Leu Ser His Lys Leu
405 410 415Gly Ala Lys Lys Thr Asp Leu Pro Ser Ser Asp Arg Glu Phe
Tyr Asn 420 425 430Lys Ala Tyr Asp Leu Leu Ala Arg Ile His Gln Asp
Leu Leu Asp Asn 435 440 445Lys Gly Arg Gln Val Asp Phe Glu Ala Leu
Asp Asn Leu Leu Glu Arg 450 455 460Leu Lys Asp Val Xaa Ser Asp Lys
Val Lys Leu Val Xaa Asp Ile Leu465 470 475 480Ala Phe Leu Ala Pro
Ile Arg His Pro Glu Arg Leu Gly Lys Pro Asn 485 490 495Ala Gln Ile
Thr Tyr Thr Asp Asp Glu Ile Gln Val Ala Lys Leu Ala 500 505 510Gly
Lys Tyr Thr Thr Glu Asp Gly Tyr Ile Phe Asp Pro Arg Asp Ile 515 520
525Thr Ser Asp Glu Gly Asp Ala Tyr Val Thr Pro His Met Thr His Ser
530 535 540His Trp Ile Lys Lys Asp Ser Leu Ser Glu Ala Glu Arg Ala
Ala Ala545 550 555 560Gln Ala Tyr Ala Lys Glu Lys Gly Leu Thr Pro
Pro Ser Thr Asp His 565 570 575Gln Asp Ser Gly Asn Thr Glu Ala Lys
Gly Ala Glu Ala Ile Tyr Asn 580 585 590Arg Val Lys Ala Ala Lys Lys
Val Pro Leu Asp Arg Met Pro Tyr Asn 595 600 605Leu Gln Tyr Thr Val
Glu Val Lys Asn Gly Ser Leu Ile Ile Pro His 610 615 620Tyr Asp His
Tyr His Asn Ile Lys Phe Glu Trp Phe Asp Glu Gly Leu625 630 635
640Tyr Glu Ala Pro Lys Gly Tyr Thr Leu Glu Asp Leu Leu Ala Thr Val
645 650 655Lys Tyr Tyr Val Glu His Pro Asn Glu Arg Pro His Ser Asp
Asn Gly 660 665 670Phe Gly Asn Ala Ser Asp His Val Gln Arg Asn Lys
Asn Gly Gln Ala 675 680 685Asp Thr Asn Gln Thr Glu Lys Pro Ser Glu
Glu Lys Pro Gln Thr Glu 690 695 700Lys Pro Glu Glu Glu Thr Pro Arg
Glu Glu Lys Pro Gln Ser Glu Lys705 710 715 720Pro Glu Ser Pro Lys
Pro Thr Glu Glu Pro Glu Glu Ser Pro Glu Glu 725 730 735Ser Glu Glu
Pro Gln Val Glu Thr Glu Lys Val Glu Glu Lys Leu Arg 740 745 750Glu
Ala Glu Asp Leu Leu Gly Lys Ile Gln Asp 755
76067352DNAStreptococcus pneumoniae 67ttataagggt gaattagaaa
aaggatacca atttgatggt tgggaaattt ctggtttcga 60aggtaaaaaa gacgctggct
atgttattaa tctatcaaaa gataccttta taaaacctgt 120attcaagaaa
atagaggaga aaaaggagga agaaaataaa cctacttttg atgtatcgaa
180aaagaaagat aacccacaag taaaccatag tcaattaaat gaaagtcaca
gaaaagagga 240tttacaaaga gaagagcatt cacaaaaatc tgattcaact
aaggatgtta cagctacagt 300tcttgataaa aacaatatca gtagtaaatc
aactactaac aatcctaata ag 35268117PRTStreptococcus pneumoniae 68Tyr
Lys Gly Glu Leu Glu Lys Gly Tyr Gln Phe Asp Gly Trp Glu Ile1 5 10
15Ser Gly Phe Glu Gly Lys Lys Asp Ala Gly Tyr Val Ile Asn Leu Ser
20 25 30Lys Asp Thr Phe Ile Lys Pro Val Phe Lys Lys Ile Glu Glu Lys
Lys 35 40 45Glu Glu Glu Asn Lys Pro Thr Phe Asp Val Ser Lys Lys Lys
Asp Asn 50 55 60Pro Gln Val Asn His Ser Gln Leu Asn Glu Ser His Arg
Lys Glu Asp65 70 75 80Leu Gln Arg Glu Glu His Ser Gln Lys Ser Asp
Ser Thr Lys Asp Val 85 90 95Thr Ala Thr Val Leu Asp Lys Asn Asn Ile
Ser Ser Lys Ser Thr Thr 100 105 110Asn Asn Pro Asn Lys
115691312DNAStreptococcus pneumoniae 69gaatgttcag gctcaagaaa
gttcaggaaa taaaatccac tttatcaatg ttcaagaagg 60tggcagtgat gcgattattc
ttgaaagcaa tggacatttt gccatggtgg atacaggaga 120agattatgat
ttcccagatg gaagtgattc tcgctatcca tggagagaag gaattgaaac
180gtcttataag catgttctaa cagaccgtgt ctttcgtcgt ttgaaggaat
tgggtgtcca 240aaaacttgat tttattttgg tgacccatac ccacagtgat
catattggaa atgttgatga 300attactgtct acctatccag ttgaccgagt
ctatcttaag aaatatagtg atagtcgtat 360tactaattct gaacgtctat
gggataatct gtatggctat gataaggttt tacagactgc 420tgcagaaaaa
ggtgtttcag ttattcaaaa tatcacacaa ggggatgctc attttcagtt
480tggggacatg gatattcagc tctataatta tgaaaatgaa actgattcat
cgggtgaatt 540aaagaaaatt tgggatgaca attccaattc cttgattagc
gtggtgaaag tcaatggcaa 600gaaaatttac cttgggggcg atttagataa
tgttcatgga gcagaagaca agtatggtcc 660tctcattgga aaagttgatt
tgatgaagtt taatcatcac catgatacca acaaatcaaa 720taccaaggat
ttcattaaaa atttgagtcc gagtttgatt gttcaaactt cggatagtct
780accttggaaa aatggtgttg atagtgagta tgttaattgg ctcaaagaac
gaggaattga 840gagaatcaac gcagccagca aagactatga tgcaacagtt
tttgatattc gaaaagacgg 900ttttgtcaat atttcaacat cctacaagcc
gattccaagt tttcaagctg gttggcataa 960gagtgcatat gggaactggt
ggtatcaagc gcctgattct acaggagagt atgctgtcgg 1020ttggaatgaa
atcgaaggtg aatggtatta ctttaaccaa acgggtatct tgttacagaa
1080tcaatggaaa aaatggaaca atcattggtt ctatttgaca gactctggtg
cttctgctaa 1140aaattggaag aaaatcgctg gaatctggta ttattttaac
aaagaaaacc agatggaaat 1200tggttggatt caagataaag agcagtggta
ttatttggat gttgatggtt ctatgaagac 1260aggatggctt caatatatgg
ggcaatggta ttactttgct ccatcagggg aa 131270437PRTStreptococcus
pneumoniae 70Asn Val Gln Ala Gln Glu Ser Ser Gly Asn Lys Ile His
Phe Ile Asn1 5 10 15Val Gln Glu Gly Gly Ser Asp Ala Ile Ile Leu Glu
Ser Asn Gly His 20 25 30Phe Ala Met Val Asp Thr Gly Glu Asp Tyr Asp
Phe Pro Asp Gly Ser 35 40 45Asp Ser Arg Tyr Pro Trp Arg Glu Gly Ile
Glu Thr Ser Tyr Lys His 50 55 60Val Leu Thr Asp Arg Val Phe Arg Arg
Leu Lys Glu Leu Gly Val Gln65 70 75 80Lys Leu Asp Phe Ile Leu Val
Thr His Thr His Ser Asp His Ile Gly 85 90 95Asn Val Asp Glu Leu Leu
Ser Thr Tyr Pro Val Asp Arg Val Tyr Leu 100 105 110Lys Lys Tyr Ser
Asp Ser Arg Ile Thr Asn Ser Glu Arg Leu Trp Asp 115 120 125Asn Leu
Tyr Gly Tyr Asp Lys Val Leu Gln Thr Ala Ala Glu Lys Gly 130 135
140Val Ser Val Ile Gln Asn Ile Thr Gln Gly Asp Ala His Phe Gln
Phe145 150 155 160Gly Asp Met Asp Ile Gln Leu Tyr Asn Tyr Glu Asn
Glu Thr Asp Ser 165 170 175Ser Gly Glu Leu Lys Lys Ile Trp Asp Asp
Asn Ser Asn Ser Leu Ile 180 185 190Ser Val Val Lys Val Asn Gly Lys
Lys Ile Tyr Leu Gly Gly Asp Leu 195 200 205Asp Asn Val His Gly Ala
Glu Asp Lys Tyr Gly Pro Leu Ile Gly Lys 210 215 220Val Asp Leu Met
Lys Phe Asn His His His Asp Thr Asn Lys Ser Asn225 230 235 240Thr
Lys Asp Phe Ile Lys Asn Leu Ser Pro Ser Leu Ile Val Gln Thr 245 250
255Ser Asp Ser Leu Pro Trp Lys Asn Gly Val Asp Ser Glu Tyr Val Asn
260 265 270Trp Leu Lys Glu Arg Gly Ile Glu Arg Ile Asn Ala Ala Ser
Lys Asp 275 280 285Tyr Asp Ala Thr Val Phe Asp Ile Arg Lys Asp Gly
Phe Val Asn Ile 290 295 300Ser Thr Ser Tyr Lys Pro Ile Pro Ser Phe
Gln Ala Gly Trp His Lys305 310 315 320Ser Ala Tyr Gly Asn Trp Trp
Tyr Gln Ala Pro Asp Ser Thr Gly Glu 325 330 335Tyr Ala Val Gly Trp
Asn Glu Ile Glu Gly Glu Trp Tyr Tyr Phe Asn 340 345 350Gln Thr Gly
Ile Leu Leu Gln Asn Gln Trp Lys Lys Trp Asn Asn His 355 360 365Trp
Phe Tyr Leu Thr Asp Ser Gly Ala Ser Ala Lys Asn Trp Lys Lys 370 375
380Ile Ala Gly Ile Trp Tyr Tyr Phe Asn Lys Glu Asn Gln Met Glu
Ile385 390 395 400Gly Trp Ile Gln Asp Lys Glu Gln Trp Tyr Tyr Leu
Asp Val Asp Gly 405 410 415Ser Met Lys Thr Gly Trp Leu Gln Tyr Met
Gly Gln Trp Tyr Tyr Phe 420 425 430Ala Pro Ser Gly Glu
435711855DNAStreptococcus pneumoniae 71cttgggtgta acccatatcc
agctccttcc agtcttgtct tactactttg tcaatgaatt 60gaaaaaccat gaacgcttgt
ctgactacgc ttcaagcaac agcaactaca actggggata 120tgaccctcaa
aactacttct ccttgactgg tatgtactca agcgatccta agaatccaga
180aaaacgaatc gcagaattta aaaacctcat caacgaaatc cacaaacgtg
gtatgggagc 240tatcctagat gtcgtttata accacacagc caaagtcgat
ctctttgaag atttggaacc 300aaactactac cactttatgg atgccgatgg
cacacctcga actagctttg gtggtggacg 360cttggggaca acccaccata
tgaccaaacg gctcctaatt gactctatca aatacctagt 420tgatacctac
aaagtggatg gcttccgttt cgatatgatg ggagaccatg acgccgcttc
480tatcgaagaa gcttacaagg ctgcacgcgc cctcaatcca aacctcatca
tgcttggtga 540aggttggaga acctatgccg gtgatgaaaa catgcctact
aaagctgctg accaagattg 600gatgaaacat accgatactg tcgctgtctt
ttcagatgac atccgtaaca acctcaaatc 660tggttatcca aacgaaggtc
aacctgcctt tatcacaggt ggcaagcgtg atgtcaacac 720catctttaaa
aatctcattg ctcaaccaac taactttgaa gctgacagcc ctggagatgt
780catccaatac atcgcagccc atgataactt gaccctcttt gacatcattg
cccagtctat 840caaaaaagac ccaagcaagg ctgagaacta tgctgaaatc
caccgtcgtt tacgacttgg 900aaatctcatg gtcttgacag ctcaaggaac
tccatttatc cactccggtc aggaatatgg 960acgtactaaa caattccgtg
acccagccta caagactcca gtagcagagg ataaggttcc 1020aaacaaatct
cacttgttgc gtgataagga cggcaaccca tttgactatc cttacttcat
1080ccatgactct tacgattcta gtgatgcagt caacaagttt gactggacta
aggctacaga 1140tggtaaagct tatcctgaaa atgtcaagag ccgtgactat
atgaaaggtt tgattgccct 1200tcgtcaatct acagatgcct tccgacttaa
gagtcttcaa gatatcaaag accgtgtcca 1260cctcatcact gtcccaggcc
aaaatggtgt ggaaaaagag gatgtagtga ttggctacca 1320aatcactgct
ccaaacggcg atatctacgc agtctttgtc aatgcggatg aaaaagctcg
1380cgaatttaat ttgggaactg cctttgcaca tctaagaaat gcggaagttt
tggcagatga 1440aaaccaagca ggaccagtcg gaattgccaa cccgaaagga
cttgaatgga ctgaaaaagg 1500cttgaaattg aatgccctta cagctactgt
tcttcgagtc tctcaaaatg gaactagcca 1560tgagtcaact gcagaagaga
aaccagactc aaccccttcc aagcctgaac atcaaaatga 1620agcttctcac
cctgcacatc aagacccagc tccagaagct agacctgatt ctactaaacc
1680agatgccaaa gtagctgatg cggaaaataa acctagccaa gctacagctg
attcacaagc 1740tgaacaacca gcacaagaag cacaagcatc atctgtaaaa
gaagcggttc gaaacgaatc 1800ggtagaaaac tctagcaagg aaaatatacc
tgcaacccca gataaacaag ctgaa 185572618PRTStreptococcus pneumoniae
72Leu Gly Val Thr His Ile Gln Leu Leu Pro Val Leu Ser Tyr Tyr Phe1
5 10 15Val Asn Glu Leu Lys Asn His Glu Arg Leu Ser Asp Tyr Ala Ser
Ser 20 25 30Asn Ser Asn Tyr Asn Trp Gly Tyr Asp Pro Gln Asn Tyr Phe
Ser Leu 35 40 45Thr Gly Met Tyr Ser Ser Asp Pro Lys Asn Pro Glu Lys
Arg Ile Ala 50 55 60Glu Phe Lys Asn Leu Ile Asn Glu Ile His Lys Arg
Gly Met Gly Ala65 70 75 80Ile Leu Asp Val Val Tyr Asn His Thr Ala
Lys Val Asp Leu Phe Glu 85 90 95Asp Leu Glu Pro Asn Tyr Tyr His Phe
Met Asp Ala Asp Gly Thr Pro 100 105 110Arg Thr Ser Phe Gly Gly Gly
Arg Leu Gly Thr Thr His His Met Thr 115 120 125Lys Arg Leu Leu Ile
Asp Ser Ile Lys Tyr Leu Val Asp Thr Tyr Lys 130 135 140Val Asp Gly
Phe Arg Phe Asp Met Met Gly Asp His Asp Ala Ala Ser145 150 155
160Ile Glu Glu Ala Tyr Lys Ala Ala Arg Ala Leu Asn Pro Asn Leu Ile
165 170 175Met Leu Gly Glu Gly Trp Arg Thr Tyr Ala Gly Asp Glu Asn
Met Pro 180 185 190Thr Lys Ala Ala Asp Gln Asp Trp Met Lys His Thr
Asp Thr Val Ala 195 200 205Val Phe Ser Asp Asp Ile Arg Asn Asn Leu
Lys Ser Gly Tyr Pro Asn 210 215 220Glu Gly Gln Pro Ala Phe Ile Thr
Gly Gly Lys Arg Asp Val Asn Thr225 230 235 240Ile Phe Lys Asn Leu
Ile Ala Gln Pro Thr Asn Phe Glu Ala Asp Ser 245 250 255Pro Gly Asp
Val Ile Gln Tyr Ile Ala Ala His Asp Asn Leu Thr Leu 260 265 270Phe
Asp Ile Ile Ala Gln Ser Ile Lys Lys Asp Pro Ser Lys Ala Glu 275 280
285Asn Tyr Ala Glu Ile His Arg Arg Leu Arg Leu Gly Asn Leu Met Val
290 295 300Leu Thr Ala Gln Gly Thr Pro Phe Ile His Ser Gly Gln Glu
Tyr Gly305 310 315 320Arg Thr Lys Gln Phe Arg Asp Pro Ala Tyr Lys
Thr Pro Val Ala Glu 325 330 335Asp Lys Val Pro Asn Lys Ser His Leu
Leu Arg Asp Lys Asp Gly Asn 340 345 350Pro Phe Asp Tyr Pro Tyr Phe
Ile His Asp Ser Tyr Asp Ser Ser Asp 355 360 365Ala Val Asn Lys Phe
Asp Trp Thr Lys Ala Thr Asp Gly Lys Ala Tyr 370 375 380Pro Glu Asn
Val Lys Ser Arg Asp Tyr Met Lys Gly Leu Ile Ala Leu385 390 395
400Arg Gln Ser Thr Asp Ala Phe Arg Leu Lys Ser Leu Gln Asp Ile Lys
405 410 415Asp Arg Val His Leu Ile Thr Val Pro Gly Gln Asn Gly Val
Glu Lys 420 425 430Glu Asp Val Val Ile Gly Tyr Gln Ile Thr Ala Pro
Asn Gly Asp Ile 435 440 445Tyr Ala Val Phe Val Asn Ala
Asp Glu Lys Ala Arg Glu Phe Asn Leu 450 455 460Gly Thr Ala Phe Ala
His Leu Arg Asn Ala Glu Val Leu Ala Asp Glu465 470 475 480Asn Gln
Ala Gly Pro Val Gly Ile Ala Asn Pro Lys Gly Leu Glu Trp 485 490
495Thr Glu Lys Gly Leu Lys Leu Asn Ala Leu Thr Ala Thr Val Leu Arg
500 505 510Val Ser Gln Asn Gly Thr Ser His Glu Ser Thr Ala Glu Glu
Lys Pro 515 520 525Asp Ser Thr Pro Ser Lys Pro Glu His Gln Asn Glu
Ala Ser His Pro 530 535 540Ala His Gln Asp Pro Ala Pro Glu Ala Arg
Pro Asp Ser Thr Lys Pro545 550 555 560Asp Ala Lys Val Ala Asp Ala
Glu Asn Lys Pro Ser Gln Ala Thr Ala 565 570 575Asp Ser Gln Ala Glu
Gln Pro Ala Gln Glu Ala Gln Ala Ser Ser Val 580 585 590Lys Glu Ala
Val Arg Asn Glu Ser Val Glu Asn Ser Ser Lys Glu Asn 595 600 605Ile
Pro Ala Thr Pro Asp Lys Gln Ala Glu 610 615731774DNAStreptococcus
pneumoniaemisc_feature(73)..(73)n is a, c, g, or t 73tagtgatggt
acttggcaag gaaaacagta tctgaaagaa gatggcagtc aagcagcaaa 60tgagtgggtt
ttngatactc attatcaatc ttggttctat ataaaagcag atgctaacta
120tgctgaaaat gaatggctaa agcaaggtga cgactatttt tacctcaaat
ctggtggcta 180tatggccaaa tcagaatggg tagaagacaa gggagccttt
tattatcttg accaagatgg 240aaagatgaaa agaaatgctt gggtaggaac
ttcctatgtt ggtgcaacag gtgccaaagt 300aatagaagac tgggtctatg
attctcaata cgatgcttgg ttttatatca aagcagatgg 360acagcacgca
gagaaagaat ggctccaaat taaagggaag gactattatt tcaaatccgg
420tggttatcta ctgacaagtc agtggattaa tcaagcttat gtgaatgcta
gtggtgccaa 480agtacagcaa ggttggcttt ttgacaaaca ataccaatct
tggttttaca tcaaagaaaa 540tggaaactat gctgataaag aatggatttt
cgagaatggt cactattatt atctaaaatc 600cggtggctac atggcagcca
atgaatggat ttgggataag gaatcttggt tttatctcaa 660atttgatggg
aaaatggctg aaaaagaatg ggtctacgat tctcatagtc aagcttggta
720ctacttcaaa tccggtggtt acatgacagc caatgaatgg atttgggata
aggaatcttg 780gttttacctc aaatctgatg ggaaaatagc tgaaaaagaa
tgggtctacg attctcatag 840tcaagcttgg tactacttca aatctggtgg
ctacatggcg aaaaatgaga cagtagatgg 900ttatcagctt ggaagcgatg
gtaaatggct tggaggaaaa actacaaatg aaaatgctgc 960ttactatcaa
gtagtgcctg ttacagccaa tgtttatgat tcagatggtg aaaagctttc
1020ctatatatcg caaggtagtg tcgtatggct agataaggat agaaaaagtg
atgacaagcg 1080cttggctatt actatttctg gtttgtcagg ctatatgaaa
acagaagatt tacaagcgct 1140agatgctagt aaggacttta tcccttatta
tgagagtgat ggccaccgtt tttatcacta 1200tgtggctcag aatgctagta
tcccagtagc ttctcatctt tctgatatgg aagtaggcaa 1260gaaatattat
tcggcagatg gcctgcattt tgatggtttt aagcttgaga atcccttcct
1320tttcaaagat ttaacagagg ctacaaacta cagtgctgaa gaattggata
aggtatttag 1380tttgctaaac attaacaata gccttttgga gaacaagggc
gctactttta aggaagccga 1440agaacattac catatcaatg ctctttatct
ccttgcccat agtgccctag aaagtaactg 1500gggaagaagt aaaattgcca
aagataagaa taatttcttt ggcattacag cctatgatac 1560gaccccttac
ctttctgcta agacatttga tgatgtggat aagggaattt taggtgcaac
1620caagtggatt aaggaaaatt atatcgatag gggaagaact ttccttggaa
acaaggcttc 1680tggtatgaat gtggaatatg cttcagaccc ttattggggc
gaaaaaattg ctagtgtgat 1740gatgaaaatc aatgagaagc taggtggcaa agat
177474591PRTStreptococcus pneumoniaeSITE(24)..(24)Xaa can be any
naturally occurring amino acid 74Ser Asp Gly Thr Trp Gln Gly Lys
Gln Tyr Leu Lys Glu Asp Gly Ser1 5 10 15Gln Ala Ala Asn Glu Trp Val
Xaa Asp Thr His Tyr Gln Ser Trp Phe 20 25 30Tyr Ile Lys Ala Asp Ala
Asn Tyr Ala Glu Asn Glu Trp Leu Lys Gln 35 40 45Gly Asp Asp Tyr Phe
Tyr Leu Lys Ser Gly Gly Tyr Met Ala Lys Ser 50 55 60Glu Trp Val Glu
Asp Lys Gly Ala Phe Tyr Tyr Leu Asp Gln Asp Gly65 70 75 80Lys Met
Lys Arg Asn Ala Trp Val Gly Thr Ser Tyr Val Gly Ala Thr 85 90 95Gly
Ala Lys Val Ile Glu Asp Trp Val Tyr Asp Ser Gln Tyr Asp Ala 100 105
110Trp Phe Tyr Ile Lys Ala Asp Gly Gln His Ala Glu Lys Glu Trp Leu
115 120 125Gln Ile Lys Gly Lys Asp Tyr Tyr Phe Lys Ser Gly Gly Tyr
Leu Leu 130 135 140Thr Ser Gln Trp Ile Asn Gln Ala Tyr Val Asn Ala
Ser Gly Ala Lys145 150 155 160Val Gln Gln Gly Trp Leu Phe Asp Lys
Gln Tyr Gln Ser Trp Phe Tyr 165 170 175Ile Lys Glu Asn Gly Asn Tyr
Ala Asp Lys Glu Trp Ile Phe Glu Asn 180 185 190Gly His Tyr Tyr Tyr
Leu Lys Ser Gly Gly Tyr Met Ala Ala Asn Glu 195 200 205Trp Ile Trp
Asp Lys Glu Ser Trp Phe Tyr Leu Lys Phe Asp Gly Lys 210 215 220Met
Ala Glu Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala Trp Tyr225 230
235 240Tyr Phe Lys Ser Gly Gly Tyr Met Thr Ala Asn Glu Trp Ile Trp
Asp 245 250 255Lys Glu Ser Trp Phe Tyr Leu Lys Ser Asp Gly Lys Ile
Ala Glu Lys 260 265 270Glu Trp Val Tyr Asp Ser His Ser Gln Ala Trp
Tyr Tyr Phe Lys Ser 275 280 285Gly Gly Tyr Met Ala Lys Asn Glu Thr
Val Asp Gly Tyr Gln Leu Gly 290 295 300Ser Asp Gly Lys Trp Leu Gly
Gly Lys Thr Thr Asn Glu Asn Ala Ala305 310 315 320Tyr Tyr Gln Val
Val Pro Val Thr Ala Asn Val Tyr Asp Ser Asp Gly 325 330 335Glu Lys
Leu Ser Tyr Ile Ser Gln Gly Ser Val Val Trp Leu Asp Lys 340 345
350Asp Arg Lys Ser Asp Asp Lys Arg Leu Ala Ile Thr Ile Ser Gly Leu
355 360 365Ser Gly Tyr Met Lys Thr Glu Asp Leu Gln Ala Leu Asp Ala
Ser Lys 370 375 380Asp Phe Ile Pro Tyr Tyr Glu Ser Asp Gly His Arg
Phe Tyr His Tyr385 390 395 400Val Ala Gln Asn Ala Ser Ile Pro Val
Ala Ser His Leu Ser Asp Met 405 410 415Glu Val Gly Lys Lys Tyr Tyr
Ser Ala Asp Gly Leu His Phe Asp Gly 420 425 430Phe Lys Leu Glu Asn
Pro Phe Leu Phe Lys Asp Leu Thr Glu Ala Thr 435 440 445Asn Tyr Ser
Ala Glu Glu Leu Asp Lys Val Phe Ser Leu Leu Asn Ile 450 455 460Asn
Asn Ser Leu Leu Glu Asn Lys Gly Ala Thr Phe Lys Glu Ala Glu465 470
475 480Glu His Tyr His Ile Asn Ala Leu Tyr Leu Leu Ala His Ser Ala
Leu 485 490 495Glu Ser Asn Trp Gly Arg Ser Lys Ile Ala Lys Asp Lys
Asn Asn Phe 500 505 510Phe Gly Ile Thr Ala Tyr Asp Thr Thr Pro Tyr
Leu Ser Ala Lys Thr 515 520 525Phe Asp Asp Val Asp Lys Gly Ile Leu
Gly Ala Thr Lys Trp Ile Lys 530 535 540Glu Asn Tyr Ile Asp Arg Gly
Arg Thr Phe Leu Gly Asn Lys Ala Ser545 550 555 560Gly Met Asn Val
Glu Tyr Ala Ser Asp Pro Tyr Trp Gly Glu Lys Ile 565 570 575Ala Ser
Val Met Met Lys Ile Asn Glu Lys Leu Gly Gly Lys Asp 580 585
590751105DNAStreptococcus pneumoniae 75tgggattcaa tatgtcagag
atgatactag agataaagaa gagggaatag agtatgatga 60cgctgacaat ggggatatta
ttgtaaaagt agcgactaaa cctaaggtag taaccaagaa 120aatttcaagt
acgcgaattc gttatgaaaa agatgaaaca aaagaccgta gtgaaaatcc
180tgttacaatt gatggagagg atggctatgt aactacgaca aggacctacg
atgttaatcc 240agagactggt tatgttaccg aacaggttac tgttgataga
aaagaagcca cggatacagt 300tatcaaagtt ccagctaaaa gcaaggttga
agaagttctt gttccatttg ctactaaata 360tgaagcagac aatgaccttt
ctgcaggaca ggagcaagag attactctag gaaagaatgg 420gaaaacagtt
acaacgataa cttataatgt agatggaaag agtggacaag taactgagag
480tactttaagt caaaaaaaag actctcaaac aagagttgtt aaaaaaagaa
ccarkcccca 540agttcttgtc caagaaattc caatcgaaac agaatatctc
gatggcccaa ctcttgataa 600aagtcaagaa gtagaagaag taggagaaat
tggtaaatta ctcttactac aatctatact 660ggtagatgaa cgtgatggaa
caattgaaga aactacttct cgtcaaatta ctaaagagat 720ggtaaaaaga
cgtataagga gagggacgag agaacctgaa aaagttgttg ttcctgagca
780atcatctatt ccttcgtatc ctgtatctgt tacatctaac caaggaacag
atgtagcagt 840agaaccagct aaagcagttg ctccaacaac agactggaaa
caagaaaatg gtatgtggta 900tttttataat actgatggtt ccatggcaac
aggttgggta caagttaata gttcatggta 960ctacctcaac agcaacggtt
ctatgaaagt caatcaatgg ttccaagttg gtggtaaatg 1020gtattatgta
aatacatcgg gtgagttagc ggtcaataca agtatagatg gctatagagt
1080caatgataat ggtgaatggg tgcgt 110576368PRTStreptococcus
pneumoniaeSITE(178)..(178)Xaa can be any naturally occurring amino
acid 76Gly Ile Gln Tyr Val Arg Asp Asp Thr Arg Asp Lys Glu Glu Gly
Ile1 5 10 15Glu Tyr Asp Asp Ala Asp Asn Gly Asp Ile Ile Val Lys Val
Ala Thr 20 25 30Lys Pro Lys Val Val Thr Lys Lys Ile Ser Ser Thr Arg
Ile Arg Tyr 35 40 45Glu Lys Asp Glu Thr Lys Asp Arg Ser Glu Asn Pro
Val Thr Ile Asp 50 55 60Gly Glu Asp Gly Tyr Val Thr Thr Thr Arg Thr
Tyr Asp Val Asn Pro65 70 75 80Glu Thr Gly Tyr Val Thr Glu Gln Val
Thr Val Asp Arg Lys Glu Ala 85 90 95Thr Asp Thr Val Ile Lys Val Pro
Ala Lys Ser Lys Val Glu Glu Val 100 105 110Leu Val Pro Phe Ala Thr
Lys Tyr Glu Ala Asp Asn Asp Leu Ser Ala 115 120 125Gly Gln Glu Gln
Glu Ile Thr Leu Gly Lys Asn Gly Lys Thr Val Thr 130 135 140Thr Ile
Thr Tyr Asn Val Asp Gly Lys Ser Gly Gln Val Thr Glu Ser145 150 155
160Thr Leu Ser Gln Lys Lys Asp Ser Gln Thr Arg Val Val Lys Lys Arg
165 170 175Thr Xaa Pro Gln Val Leu Val Gln Glu Ile Pro Ile Glu Thr
Glu Tyr 180 185 190Leu Asp Gly Pro Thr Leu Asp Lys Ser Gln Glu Val
Glu Glu Val Gly 195 200 205Glu Ile Gly Lys Leu Leu Leu Leu Gln Ser
Ile Leu Val Asp Glu Arg 210 215 220Asp Gly Thr Ile Glu Glu Thr Thr
Ser Arg Gln Ile Thr Lys Glu Met225 230 235 240Val Lys Arg Arg Ile
Arg Arg Gly Thr Arg Glu Pro Glu Lys Val Val 245 250 255Val Pro Glu
Gln Ser Ser Ile Pro Ser Tyr Pro Val Ser Val Thr Ser 260 265 270Asn
Gln Gly Thr Asp Val Ala Val Glu Pro Ala Lys Ala Val Ala Pro 275 280
285Thr Thr Asp Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn Thr
290 295 300Asp Gly Ser Met Ala Thr Gly Trp Val Gln Val Asn Ser Ser
Trp Tyr305 310 315 320Tyr Leu Asn Ser Asn Gly Ser Met Lys Val Asn
Gln Trp Phe Gln Val 325 330 335Gly Gly Lys Trp Tyr Tyr Val Asn Thr
Ser Gly Glu Leu Ala Val Asn 340 345 350Thr Ser Ile Asp Gly Tyr Arg
Val Asn Asp Asn Gly Glu Trp Val Arg 355 360
36577661DNAStreptococcus pneumoniae 77ggataataga gaagcattaa
aaacctttat gacgggtgaa aatttttatc tccaacatta 60tctaggagca catagggaag
aactaaatgg agagcatggc tataccttcc gtgtttgggc 120acctaatgct
caggctgttc acttggttgg tgattttacc aactggattg aaaatcagat
180tccaatggta agaaatgatt ttggggtctg ggaagtcttt accaatatgg
ctcaagaagg 240gcatatttac aaatatcatg tcacacgtca aaatggtcat
caactgatga agattgaccc 300ttttgctgtc aggtatgagg ctcgtccagg
aacaggggca atcgtaacag agcttcctga 360gaagaaatgg aaggatggac
tttggctggc acgaagaaaa cgttggggct ttgaagagcg 420tcctgtcaat
atttatgaag ttcacgctgg atcatggaaa agaaattctg atggcagtcc
480ttatagtttt gcccagctca aggatgaact cattccttat ctcgttgaaa
tgaactatac 540tcatattgag tttatgccct tgatgtccca tcctttgggc
ttgagttggg ggtatcagct 600tatgggttac ttcgctttag agcatgctta
tggccgacca gaggagtttc aagattttgt 660c 66178220PRTStreptococcus
pneumoniae 78Asp Asn Arg Glu Ala Leu Lys Thr Phe Met Thr Gly Glu
Asn Phe Tyr1 5 10 15Leu Gln His Tyr Leu Gly Ala His Arg Glu Glu Leu
Asn Gly Glu His 20 25 30Gly Tyr Thr Phe Arg Val Trp Ala Pro Asn Ala
Gln Ala Val His Leu 35 40 45Val Gly Asp Phe Thr Asn Trp Ile Glu Asn
Gln Ile Pro Met Val Arg 50 55 60Asn Asp Phe Gly Val Trp Glu Val Phe
Thr Asn Met Ala Gln Glu Gly65 70 75 80His Ile Tyr Lys Tyr His Val
Thr Arg Gln Asn Gly His Gln Leu Met 85 90 95Lys Ile Asp Pro Phe Ala
Val Arg Tyr Glu Ala Arg Pro Gly Thr Gly 100 105 110Ala Ile Val Thr
Glu Leu Pro Glu Lys Lys Trp Lys Asp Gly Leu Trp 115 120 125Leu Ala
Arg Arg Lys Arg Trp Gly Phe Glu Glu Arg Pro Val Asn Ile 130 135
140Tyr Glu Val His Ala Gly Ser Trp Lys Arg Asn Ser Asp Gly Ser
Pro145 150 155 160Tyr Ser Phe Ala Gln Leu Lys Asp Glu Leu Ile Pro
Tyr Leu Val Glu 165 170 175Met Asn Tyr Thr His Ile Glu Phe Met Pro
Leu Met Ser His Pro Leu 180 185 190Gly Leu Ser Trp Gly Tyr Gln Leu
Met Gly Tyr Phe Ala Leu Glu His 195 200 205Ala Tyr Gly Arg Pro Glu
Glu Phe Gln Asp Phe Val 210 215 22079976DNAStreptococcus
pneumoniaemisc_feature(60)..(60)n is a, c, g, or t 79agattttgtc
gaggagtgtc atacccataa tattggggtt attgtggact gggtaccagn 60tcactttacc
atcaacgatg atgccttagc ctattatgat gggacaccga cttttgaata
120ccaagaccat aataaggctc ataaccatgg ttggggtgcc cttaattttg
accttggaaa 180aaatgaagtc cagtccttct taatttcttg cattaagcat
tggattgatg tctatcattt 240ggatggtatt cgtgtggatg ctgttagcaa
catgctctat ttggactatg atgatgctcc 300atggacacct aataaagatg
gcggaaatct caactatgaa ggttattatt tccttcagcg 360cttgaatgag
gttattaagt tagaatatcc agatgtgatg atgattgcag aagaaagttc
420gtctgcgatc aagattacgg gaatgaaaga gattggtggt ctaggatttg
actacaaatg 480gaacatgggc tggatgaatg atatcctccg tttctacgaa
gaagatccga tctatcgtaa 540atatgacttt aacctggtga ctttcagctt
tatgtatgtt tncaaggaga attatctctt 600gccattctcg cacgatgaag
tggttcatgg caagaagagt atgatgcata agatgtgggg 660agatcgttac
aatcaattcg caggcttgcg caatctctat acgtaccaaa tttgtcaccc
720tggtaagaaa ttgctcttca tgggtagcga atacggtcaa ttcctagaat
ggaaatctga 780agaacagttg gaatggtcta acctagaaga cccaatgaat
gctaagatga agtatttcgc 840ttctcagcta aaccagtttt acaaagatca
tcgctgtctg tgggaaattg ataccagcta 900tgatggtatt gaaatcattg
atgcggataa tcgagaccag agtgttcttt cctttattcg 960taagggtaaa aaggga
97680325PRTStreptococcus pneumoniaeSITE(20)..(20)Xaa can be any
naturally occurring amino acid 80Asp Phe Val Glu Glu Cys His Thr
His Asn Ile Gly Val Ile Val Asp1 5 10 15Trp Val Pro Xaa His Phe Thr
Ile Asn Asp Asp Ala Leu Ala Tyr Tyr 20 25 30Asp Gly Thr Pro Thr Phe
Glu Tyr Gln Asp His Asn Lys Ala His Asn 35 40 45His Gly Trp Gly Ala
Leu Asn Phe Asp Leu Gly Lys Asn Glu Val Gln 50 55 60Ser Phe Leu Ile
Ser Cys Ile Lys His Trp Ile Asp Val Tyr His Leu65 70 75 80Asp Gly
Ile Arg Val Asp Ala Val Ser Asn Met Leu Tyr Leu Asp Tyr 85 90 95Asp
Asp Ala Pro Trp Thr Pro Asn Lys Asp Gly Gly Asn Leu Asn Tyr 100 105
110Glu Gly Tyr Tyr Phe Leu Gln Arg Leu Asn Glu Val Ile Lys Leu Glu
115 120 125Tyr Pro Asp Val Met Met Ile Ala Glu Glu Ser Ser Ser Ala
Ile Lys 130 135 140Ile Thr Gly Met Lys Glu Ile Gly Gly Leu Gly Phe
Asp Tyr Lys Trp145 150 155 160Asn Met Gly Trp Met Asn Asp Ile Leu
Arg Phe Tyr Glu Glu Asp Pro 165 170 175Ile Tyr Arg Lys Tyr Asp Phe
Asn Leu Val Thr Phe Ser Phe Met Tyr 180 185 190Val Xaa Lys Glu Asn
Tyr Leu Leu Pro Phe Ser His Asp Glu Val Val 195 200 205His Gly Lys
Lys Ser Met Met His Lys Met Trp Gly Asp Arg Tyr Asn 210 215 220Gln
Phe Ala Gly Leu Arg Asn Leu Tyr Thr Tyr Gln Ile Cys His Pro225 230
235 240Gly Lys Lys Leu Leu Phe Met Gly Ser Glu Tyr Gly Gln Phe Leu
Glu 245 250 255Trp Lys Ser Glu Glu Gln Leu Glu Trp Ser Asn Leu Glu
Asp Pro Met 260 265 270Asn Ala Lys Met Lys Tyr Phe Ala Ser Gln Leu
Asn Gln Phe Tyr Lys
275 280 285Asp His Arg Cys Leu Trp Glu Ile Asp Thr Ser Tyr Asp Gly
Ile Glu 290 295 300Ile Ile Asp Ala Asp Asn Arg Asp Gln Ser Val Leu
Ser Phe Ile Arg305 310 315 320Lys Gly Lys Lys Gly
325812134DNAStreptococcus pneumoniaemisc_feature(167)..(167)n is a,
c, g, or t 81atctgtagtt tatgcggatg aaacacttat tactcatact gctgagaaac
ctaaagagga 60aaaaatgata gtagaagaaa aggctgataa agctttggaa actaaaaata
tagttgaaag 120gacagaacaa agtgaaccta gttcaactga ggctattgca
tctgagnaga aagaagatga 180agccgtaact ccaaaagagg aaaaagtgtc
tgctaaaccg gaagaaaaag ctccaaggat 240agaatcacaa gcttcaaatc
aagaaaaacc gctcaaggaa gatgctaaag ctgtaacaaa 300tgaagaagtg
aatcaaatga ttgaagacag gaaagtggat tttaatcaaa attggtactt
360taaactcaat gcaaattcta aggaagccat taaacctgat gcagacgtat
ctacgtggaa 420aaaattagat ttaccgtatg actggagtat ctttaacgat
ttcgatcatg aatctcctgc 480acaaaatgaa ggtggacagc tcaacggtgg
ggaagcttgg tatcgcaaga ctttcaaact 540agatgaaaaa gacctcaaga
aaaatgttcg ccttactttt gatggcgtct acatggattc 600tcaagtttat
gtcaatggtc agttagtggg gcattatcca aatggttata accagttctc
660atatgatatc accaaatacc ttcaaaaaga tggtcgtgag aatgtgattg
ctgtccatgc 720agtcaacaaa cagccaagta gccgttggta ttcaggaagt
ggtatctatc gtgatgtgac 780tttacaagtg acagataagg tgcatgttga
gaaaaatggg acaactattt taacaccaaa 840acttgaagaa caacaacatg
gcaaggttga aactcatgtg accagcaaaa tcgtcaatac 900ggacgacaaa
gaccatgaac ttgtagccga atatcaaatc gttgaacgag gtggtcatgc
960tgtaacaggc ttagttcgta cagcgagtcg taccttaaaa gcacatgaat
caacaagcct 1020agatgcgatt ttagaagttg aaagaccaaa actctggact
gttttaaatg acaaacctgc 1080cttgtacgaa ttgattacgc gtgtttaccg
tgacggtcaa ttggttgatg ctaagaagga 1140tttgtttggt taccgttact
atcactggac tccaaatgaa ggtttctctt tgaatggtga 1200acgtattaaa
ttccatggag tatccttgca ccacgaccat ggggcgcttg gagcagaaga
1260aaactataaa gcagaatatc gccgtctcaa acaaatgaag gagatgggag
ttaactccat 1320ccgtacaacc cacaaccctg ctagtgagca aaccttgcaa
atcgcagcag aactaggttt 1380actcgttcag gaagaggcct ttgatacgtg
gtatggtggc aagaaacctt atgactatgg 1440acgtttcttt gaaaaagatg
ccactcaccc agaagctcga aaaggtgaaa aatggtctga 1500ttttgaccta
cgtaccatgg tcgaaagagg caaaaacaac cctgctatct tcatgtggtc
1560aattggtaat gaaataggtg aagctaatgg tgatgcccac tctttagcaa
ctgttaaacg 1620tttggttaag gttatcaagg atgttgataa gactcgctat
gttaccatgg gagcagataa 1680attccgtttc ggtaatggta gcggagggca
tgagaaaatt gctgatgaac tcgatgctgt 1740tggatttaac tattctgaag
ataattacaa agcccttaga gctaagcatc caaaatggtt 1800gatttatgga
tcagaaacat cttcagctac ccgtacacgt ggaagttact atcgccctga
1860acgtgaattg aaacatagca atggacctga gcgtaattat gaacagtcag
attatggaaa 1920tgatcgtgtg ggttggggga aaacagcaac cgcttcatgg
acttttgacc gtgacaacgc 1980tggctatgct ggacagttta tctggacagg
tacggactat attggtgaac ctacaccatg 2040gcacaaccaa aatcaaactc
ctgttaagag ctcttacttt ggtatcgtag atacagccgg 2100cattccaaaa
catgacttct atctctacca aagc 213482711PRTStreptococcus
pneumoniaeSITE(56)..(56)Xaa can be any naturally occurring amino
acid 82Ser Val Val Tyr Ala Asp Glu Thr Leu Ile Thr His Thr Ala Glu
Lys1 5 10 15Pro Lys Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys
Ala Leu 20 25 30Glu Thr Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu
Pro Ser Ser 35 40 45Thr Glu Ala Ile Ala Ser Glu Xaa Lys Glu Asp Glu
Ala Val Thr Pro 50 55 60Lys Glu Glu Lys Val Ser Ala Lys Pro Glu Glu
Lys Ala Pro Arg Ile65 70 75 80Glu Ser Gln Ala Ser Asn Gln Glu Lys
Pro Leu Lys Glu Asp Ala Lys 85 90 95Ala Val Thr Asn Glu Glu Val Asn
Gln Met Ile Glu Asp Arg Lys Val 100 105 110Asp Phe Asn Gln Asn Trp
Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu 115 120 125Ala Ile Lys Pro
Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu 130 135 140Pro Tyr
Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala145 150 155
160Gln Asn Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys
165 170 175Thr Phe Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg
Leu Thr 180 185 190Phe Asp Gly Val Tyr Met Asp Ser Gln Val Tyr Val
Asn Gly Gln Leu 195 200 205Val Gly His Tyr Pro Asn Gly Tyr Asn Gln
Phe Ser Tyr Asp Ile Thr 210 215 220Lys Tyr Leu Gln Lys Asp Gly Arg
Glu Asn Val Ile Ala Val His Ala225 230 235 240Val Asn Lys Gln Pro
Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr 245 250 255Arg Asp Val
Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn 260 265 270Gly
Thr Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys 275 280
285Val Glu Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp
290 295 300His Glu Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly
His Ala305 310 315 320Val Thr Gly Leu Val Arg Thr Ala Ser Arg Thr
Leu Lys Ala His Glu 325 330 335Ser Thr Ser Leu Asp Ala Ile Leu Glu
Val Glu Arg Pro Lys Leu Trp 340 345 350Thr Val Leu Asn Asp Lys Pro
Ala Leu Tyr Glu Leu Ile Thr Arg Val 355 360 365Tyr Arg Asp Gly Gln
Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr 370 375 380Arg Tyr Tyr
His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu385 390 395
400Arg Ile Lys Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu
405 410 415Gly Ala Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys
Gln Met 420 425 430Lys Glu Met Gly Val Asn Ser Ile Arg Thr Thr His
Asn Pro Ala Ser 435 440 445Glu Gln Thr Leu Gln Ile Ala Ala Glu Leu
Gly Leu Leu Val Gln Glu 450 455 460Glu Ala Phe Asp Thr Trp Tyr Gly
Gly Lys Lys Pro Tyr Asp Tyr Gly465 470 475 480Arg Phe Phe Glu Lys
Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu 485 490 495Lys Trp Ser
Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn 500 505 510Asn
Pro Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala 515 520
525Asn Gly Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val
530 535 540Ile Lys Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala
Asp Lys545 550 555 560Phe Arg Phe Gly Asn Gly Ser Gly Gly His Glu
Lys Ile Ala Asp Glu 565 570 575Leu Asp Ala Val Gly Phe Asn Tyr Ser
Glu Asp Asn Tyr Lys Ala Leu 580 585 590Arg Ala Lys His Pro Lys Trp
Leu Ile Tyr Gly Ser Glu Thr Ser Ser 595 600 605Ala Thr Arg Thr Arg
Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys 610 615 620His Ser Asn
Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn625 630 635
640Asp Arg Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp
645 650 655Arg Asp Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly
Thr Asp 660 665 670Tyr Ile Gly Glu Pro Thr Pro Trp His Asn Gln Asn
Gln Thr Pro Val 675 680 685Lys Ser Ser Tyr Phe Gly Ile Val Asp Thr
Ala Gly Ile Pro Lys His 690 695 700Asp Phe Tyr Leu Tyr Gln Ser705
710832167DNAStreptococcus pneumoniae 83ttactttggt atcgtagata
cagccggcat tccaaaacat gacttctatc tctaccaaag 60ccaatgggtt tctgttaaga
agaaaccgat ggtacacctt cttcctcact ggaactggga 120aaacaaagaa
ttagcatcca aagtagctga ctcagaaggt aagattccag ttcgtgctta
180ttcgaatgct tctagtgtag aattgttctt gaatggaaaa tctcttggtc
ttaagacttt 240caataaaaaa caaaccagcg atgggcggac ttaccaagaa
ggtgcaaatg ctaatgaact 300ttatcttgaa tggaaagttg cctatcaacc
aggtaccttg gaagcaattg ctcgtgatga 360atctggcaag gaaattgctc
gagataagat tacgactgct ggtaagccag cggcagttcg 420tcttattaag
gaagaccatg cgattgcagc agatggaaaa gacttgactt acatctacta
480tgaaattgtt gacagccagg ggaatgtggt tccaactgct aataatctgg
ttcgcttcca 540attgcatggc caaggtcaac tggtcggtgt agataacgga
gaacaagcca gccgtgaacg 600ctataaggcg caagcagatg gttcttggat
tcgtaaagca tttaatggta aaggtgttgc 660cattgtcaaa tcaactgaac
aagcagggaa attcaccctg actgcccact ctgatctctt 720gaaatcgaac
caagtcactg tctttactgg taagaaagaa ggacaagaga agactgtttt
780ggggacagaa gtgccaaaag tacagaccat tattggagag gcacctgaaa
tgcctaccac 840tgttccgttt gtatacagtg atggtagccg tgcagaacgt
cctgtaacct ggtcttcagt 900agatgtgagc aagcctggta ttgtaacggt
gaaaggtatg gctgacggac gagaagtaga 960agctcgtgta gaagtgattg
ctcttaaatc agagctacca gttgtgaaac gtattgctcc 1020aaatactgac
ttgaattctg tagacaaatc tgtttcctat gttttgattg atggaagtgt
1080tgaagagtat gaagtggaca agtgggagat tgccgaagaa gataaagcta
agttagcaat 1140tccaggttct cgtattcaag cgaccggtta tttagaaggt
caaccaattc atgcaaccct 1200tgtggtagaa gaaggcaatc ctgcggcacc
tgcagtacca actgtaacgg ttggtggtga 1260ggcagtaaca ggtcttacta
gtcaaaaacc aatgcaatac cgcactcttg cttatggagc 1320taagttgcca
gaagtcacag caagtgctaa aaatgcagct gttacagttc ttcaagcaag
1380cgcagcaaac ggcatgcgtg cgagcatctt tattcagcct aaagatggtg
gccctcttca 1440aacctatgca attcaattcc ttgaagaagc gccaaaaatt
gctcacttga gcttgcaagt 1500ggaaaaagct gacagtctca aagaagacca
aactgtcaaa ttgtcggttc gagctcacta 1560tcaagatgga acgcaagctg
tattaccagc tgataaagta accttctcta caagtggtga 1620aggggaagtc
gcaattcgta aaggaatgct tgagttgcat aagccaggag cagtcactct
1680gaacgctgaa tatgagggag ctaaagacca agttgaactc actatccaag
ccaatactga 1740gaagaagatt gcgcaatcca tccgtcctgt aaatgtagtg
acagatttgc atcaggaacc 1800aagtcttcca gcaacagtaa cagttgagta
tgacaaaggt ttccctaaaa ctcataaagt 1860cacttggcaa gctattccga
aagaaaaact agactcctat caaacatttg aagtactagg 1920taaagttgaa
ggaattgacc ttgaagcgcg tgcaaaagtc tctgtagaag gtatcgtttc
1980agttgaagaa gtcagtgtga caactccaat cgcagaagca ccacaattac
cagaaagtgt 2040tcggacatat gattcaaatg gtcacgtttc atcagctaag
gttgcatggg atgcgattcg 2100tccagagcaa tacgctaagg aaggtgtctt
tacagttaat ggtcgcttag aaggtacgca 2160attaaca
216784722PRTStreptococcus pneumoniae 84Tyr Phe Gly Ile Val Asp Thr
Ala Gly Ile Pro Lys His Asp Phe Tyr1 5 10 15Leu Tyr Gln Ser Gln Trp
Val Ser Val Lys Lys Lys Pro Met Val His 20 25 30Leu Leu Pro His Trp
Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val 35 40 45Ala Asp Ser Glu
Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser 50 55 60Ser Val Glu
Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe65 70 75 80Asn
Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn 85 90
95Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr
100 105 110Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala
Arg Asp 115 120 125Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg
Leu Ile Lys Glu 130 135 140Asp His Ala Ile Ala Ala Asp Gly Lys Asp
Leu Thr Tyr Ile Tyr Tyr145 150 155 160Glu Ile Val Asp Ser Gln Gly
Asn Val Val Pro Thr Ala Asn Asn Leu 165 170 175Val Arg Phe Gln Leu
His Gly Gln Gly Gln Leu Val Gly Val Asp Asn 180 185 190Gly Glu Gln
Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser 195 200 205Trp
Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser 210 215
220Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu
Leu225 230 235 240Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys
Glu Gly Gln Glu 245 250 255Lys Thr Val Leu Gly Thr Glu Val Pro Lys
Val Gln Thr Ile Ile Gly 260 265 270Glu Ala Pro Glu Met Pro Thr Thr
Val Pro Phe Val Tyr Ser Asp Gly 275 280 285Ser Arg Ala Glu Arg Pro
Val Thr Trp Ser Ser Val Asp Val Ser Lys 290 295 300Pro Gly Ile Val
Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu305 310 315 320Ala
Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys 325 330
335Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val Ser
340 345 350Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp
Lys Trp 355 360 365Glu Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile
Pro Gly Ser Arg 370 375 380Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln
Pro Ile His Ala Thr Leu385 390 395 400Val Val Glu Glu Gly Asn Pro
Ala Ala Pro Ala Val Pro Thr Val Thr 405 410 415Val Gly Gly Glu Ala
Val Thr Gly Leu Thr Ser Gln Lys Pro Met Gln 420 425 430Tyr Arg Thr
Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala Ser 435 440 445Ala
Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly 450 455
460Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu
Gln465 470 475 480Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys
Ile Ala His Leu 485 490 495Ser Leu Gln Val Glu Lys Ala Asp Ser Leu
Lys Glu Asp Gln Thr Val 500 505 510Lys Leu Ser Val Arg Ala His Tyr
Gln Asp Gly Thr Gln Ala Val Leu 515 520 525Pro Ala Asp Lys Val Thr
Phe Ser Thr Ser Gly Glu Gly Glu Val Ala 530 535 540Ile Arg Lys Gly
Met Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu545 550 555 560Asn
Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr Ile Gln 565 570
575Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val
580 585 590Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val
Thr Val 595 600 605Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val
Thr Trp Gln Ala 610 615 620Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln
Thr Phe Glu Val Leu Gly625 630 635 640Lys Val Glu Gly Ile Asp Leu
Glu Ala Arg Ala Lys Val Ser Val Glu 645 650 655Gly Ile Val Ser Val
Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu 660 665 670Ala Pro Gln
Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His 675 680 685Val
Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr 690 695
700Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr
Gln705 710 715 720Leu Thr852329DNAStreptococcus pneumoniae
85agctaaggtt gcatgggatg cgattcgtcc agagcaatac gctaaggaag gtgtctttac
60agttaatggt cgcttagaag gtacgcaatt aacaactaaa cttcatgttc gcgtatctgc
120tcaaactgag caaggtgcaa acatttctga ccaatggacc ggttcagaat
tgccacttgc 180ctttgcttca gactcaaatc caagcgaccc agtttcaaat
gttaatgaca agctcatttc 240ctacaataac caaccagcca atcgttggac
aaactggaat cgtactaatc cagaagcttc 300agtcggtgtt ctgtttggag
attcaggtat cttgagcaaa cgctccgttg ataatctaag 360tgtcggattc
catgaagacc atggagttgg tgtaccgaag tcttatgtga ttgagtatta
420tgttggtaag actgtcccaa cagctcctaa aaaccctagt tttgttggta
atgaggacca 480tgtctttaat gattctgcca actggaaacc agttactaat
ctaaaagccc ctgctcaact 540caaggctgga gaaatgaacc actttagctt
tgataaagtt gaaacctatg ctgttcgtat 600tcgcatggtt aaagcagata
acaagcgtgg aacgtctatc acagaggtac aaatctttgc 660gaaacaagtt
gcggcagcca agcaaggaca aacaagaatc caagttgacg gcaaagactt
720agcaaacttc aaccctgatt tgacagacta ctaccttgag tctgtagatg
gaaaagttcc 780ggcagtcaca gcaagtgtta gcaacaatgg tctcgctacc
gtcgttccaa gcgttcgtga 840aggtgagcca gttcgtgtca tcgcgaaagc
tgaaaatggc gacatcttag gagaataccg 900tctgcacttc actaaggata
agagcttact ttctcataaa ccagttgctg cggttaaaca 960agctcgcttg
ctacaagtag gtcaagcact tgaattgccg actaaggttc cagtttactt
1020cacaggtaaa gacggctacg aaacaaaaga cctgacagtt gaatgggaag
aagttccagc 1080ggaaaatctg acaaaagcag gtcaatttac tgttcgaggc
cgtgtccttg gtagtaacct 1140tgttgctgag atcactgtac gagtgacaga
caaacttggt gagactcttt cagataaccc 1200taactatgat gaaaacagta
accaggcctt tgcttcagca accaatgata ttgacaaaaa 1260ctctcatgac
cgcgttgact atctcaatga cggagatcat tcagaaaatc gtcgttggac
1320aaactggtca ccaacaccat cttctaatcc agaagtatca gcgggtgtga
ttttccgtga 1380aaatggtaag attgtagaac ggactgttac acaaggaaaa
gttcagttct ttgcagatag
1440tggtacggat gcaccatcta aactcgtttt agaacgctat gtcggtccag
agtttgaagt 1500gccaacctac tattcaaact accaagccta cgacgcagac
catccattca acaatccaga 1560aaattgggaa gctgttcctt atcgtgcgga
taaagacatt gcagctggtg atgaaatcaa 1620cgtaacattt aaagctatca
aagccaaagc tatgagatgg cgtatggagc gtaaagcaga 1680taagagcggt
gttgcgatga ttgagatgac cttccttgca ccaagtgaat tgcctcaaga
1740aagcactcaa tcaaagattc ttgtagatgg aaaagaactt gctgatttcg
ctgaaaatcg 1800tcaagactat caaattacct ataaaggtca acggccaaaa
gtctcagttg aagaaaacaa 1860tcaagtagct tcaactgtgg tagatagtgg
agaagatagc tttccagtac ttgttcgcct 1920cgtttcagaa agtggaaaac
aagtcaagga ataccgtatc cacttgacta aggaaaaacc 1980agtttctgag
aagacagttg ctgctgtaca agaagatctt ccaaaaatcg aatttgttga
2040aaaagatttg gcatacaaga cagttgagaa aaaagattca acactgtatc
taggtgaaac 2100tcgtgtagaa caagaaggaa aagttggaaa agaacgtatc
tttacagcga ttaatcctga 2160tggaagtaag gaagaaaaac tccgtgaagt
ggtagaagtt ccgacagacc gcatcgtctt 2220ggttggaacc aaaccagtag
ctcaagaagc taaaaaacca caagtgtcag aaaaagcaga 2280tacaaaacca
attgattcaa gtgaagctag tcaaactaat aaagcccag
232986776PRTStreptococcus pneumoniae 86Ala Lys Val Ala Trp Asp Ala
Ile Arg Pro Glu Gln Tyr Ala Lys Glu1 5 10 15Gly Val Phe Thr Val Asn
Gly Arg Leu Glu Gly Thr Gln Leu Thr Thr 20 25 30Lys Leu His Val Arg
Val Ser Ala Gln Thr Glu Gln Gly Ala Asn Ile 35 40 45Ser Asp Gln Trp
Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala Ser Asp 50 55 60Ser Asn Pro
Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu Ile Ser65 70 75 80Tyr
Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg Thr Asn 85 90
95Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile Leu Ser
100 105 110Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp
His Gly 115 120 125Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr
Val Gly Lys Thr 130 135 140Val Pro Thr Ala Pro Lys Asn Pro Ser Phe
Val Gly Asn Glu Asp His145 150 155 160Val Phe Asn Asp Ser Ala Asn
Trp Lys Pro Val Thr Asn Leu Lys Ala 165 170 175Pro Ala Gln Leu Lys
Ala Gly Glu Met Asn His Phe Ser Phe Asp Lys 180 185 190Val Glu Thr
Tyr Ala Val Arg Ile Arg Met Val Lys Ala Asp Asn Lys 195 200 205Arg
Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln Val Ala 210 215
220Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys Asp
Leu225 230 235 240Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu
Glu Ser Val Asp 245 250 255Gly Lys Val Pro Ala Val Thr Ala Ser Val
Ser Asn Asn Gly Leu Ala 260 265 270Thr Val Val Pro Ser Val Arg Glu
Gly Glu Pro Val Arg Val Ile Ala 275 280 285Lys Ala Glu Asn Gly Asp
Ile Leu Gly Glu Tyr Arg Leu His Phe Thr 290 295 300Lys Asp Lys Ser
Leu Leu Ser His Lys Pro Val Ala Ala Val Lys Gln305 310 315 320Ala
Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr Lys Val 325 330
335Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp Leu Thr
340 345 350Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala
Gly Gln 355 360 365Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu
Val Ala Glu Ile 370 375 380Thr Val Arg Val Thr Asp Lys Leu Gly Glu
Thr Leu Ser Asp Asn Pro385 390 395 400Asn Tyr Asp Glu Asn Ser Asn
Gln Ala Phe Ala Ser Ala Thr Asn Asp 405 410 415Ile Asp Lys Asn Ser
His Asp Arg Val Asp Tyr Leu Asn Asp Gly Asp 420 425 430His Ser Glu
Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro Ser Ser 435 440 445Asn
Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly Lys Ile 450 455
460Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln Phe Phe Ala Asp
Ser465 470 475 480Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg
Tyr Val Gly Pro 485 490 495Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn
Tyr Gln Ala Tyr Asp Ala 500 505 510Asp His Pro Phe Asn Asn Pro Glu
Asn Trp Glu Ala Val Pro Tyr Arg 515 520 525Ala Asp Lys Asp Ile Ala
Ala Gly Asp Glu Ile Asn Val Thr Phe Lys 530 535 540Ala Ile Lys Ala
Lys Ala Met Arg Trp Arg Met Glu Arg Lys Ala Asp545 550 555 560Lys
Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro Ser Glu 565 570
575Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly Lys Glu
580 585 590Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr
Tyr Lys 595 600 605Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn
Gln Val Ala Ser 610 615 620Thr Val Val Asp Ser Gly Glu Asp Ser Phe
Pro Val Leu Val Arg Leu625 630 635 640Val Ser Glu Ser Gly Lys Gln
Val Lys Glu Tyr Arg Ile His Leu Thr 645 650 655Lys Glu Lys Pro Val
Ser Glu Lys Thr Val Ala Ala Val Gln Glu Asp 660 665 670Leu Pro Lys
Ile Glu Phe Val Glu Lys Asp Leu Ala Tyr Lys Thr Val 675 680 685Glu
Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln 690 695
700Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr Ala Ile Asn Pro
Asp705 710 715 720Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val Glu
Val Pro Thr Asp 725 730 735Arg Ile Val Leu Val Gly Thr Lys Pro Val
Ala Gln Glu Ala Lys Lys 740 745 750Pro Gln Val Ser Glu Lys Ala Asp
Thr Lys Pro Ile Asp Ser Ser Glu 755 760 765Ala Ser Gln Thr Asn Lys
Ala Gln 770 77587133DNAStreptococcus pneumoniae 87ctatcactat
gtaaataaag agattatttc acaagaagct aaagatttaa ttcagacagg 60aaagcctgac
aggaatgaag ttgtatatgg tttggtgtat caaaaagatc agttgcctca
120aacagggaca gaa 1338844PRTStreptococcus pneumoniae 88Tyr His Tyr
Val Asn Lys Glu Ile Ile Ser Gln Glu Ala Lys Asp Leu1 5 10 15Ile Gln
Thr Gly Lys Pro Asp Arg Asn Glu Val Val Tyr Gly Leu Val 20 25 30Tyr
Gln Lys Asp Gln Leu Pro Gln Thr Gly Thr Glu 35
4089775DNAStreptococcus pneumoniae 89tgagactcct caatcaataa
caaatcagga gcaagctagg acagaaaacc aagtagtaga 60gacagaggaa gctccaaaag
aagaagcacc taaaacagaa gaaagtccaa aggaagaacc 120aaaatcggag
gtaaaaccta ctgacgacac ccttcctaaa gtagaagagg ggaaagaaga
180ttcagcagaa ccagctccag ttgaagaagt aggtggagaa gttgagtcaa
aaccagagga 240aaaagtagca gttaagccag aaagtcaacc atcagacaaa
ccagctgagg aatcaaaagt 300tgaacaagca ggtgaaccag tcgcgccaag
agaagacgaa aaggcaccag tcgagccaga 360aaagcaacca gaagctcctg
aagaagagaa ggctgtagag gaaacaccga aacaagaaga 420gtcaactcca
gataccaagg ctgaagaaac tgtagaacca aaagaggaga ctgttaatca
480atctattgaa caaccaaaag ttgaaacgcc tgctgtagaa aaacaaacag
aaccaacaga 540ggaaccaaaa gttgaacaag caggtgaacc agtcgcgcca
agagaagacg aacaggcacc 600aacggcacca gttgagccag aaaagcaacc
agaagttcct gaagaagaga aggctgtaga 660ggaaacaccg aaaccagaag
ataaaataaa gggtattggt actaaagaac cagttgataa 720aagtgagtta
aataatcaaa ttgataaagc tagttcagtt tctcctactg attat
77590258PRTStreptococcus pneumoniae 90Glu Thr Pro Gln Ser Ile Thr
Asn Gln Glu Gln Ala Arg Thr Glu Asn1 5 10 15Gln Val Val Glu Thr Glu
Glu Ala Pro Lys Glu Glu Ala Pro Lys Thr 20 25 30Glu Glu Ser Pro Lys
Glu Glu Pro Lys Ser Glu Val Lys Pro Thr Asp 35 40 45Asp Thr Leu Pro
Lys Val Glu Glu Gly Lys Glu Asp Ser Ala Glu Pro 50 55 60Ala Pro Val
Glu Glu Val Gly Gly Glu Val Glu Ser Lys Pro Glu Glu65 70 75 80Lys
Val Ala Val Lys Pro Glu Ser Gln Pro Ser Asp Lys Pro Ala Glu 85 90
95Glu Ser Lys Val Glu Gln Ala Gly Glu Pro Val Ala Pro Arg Glu Asp
100 105 110Glu Lys Ala Pro Val Glu Pro Glu Lys Gln Pro Glu Ala Pro
Glu Glu 115 120 125Glu Lys Ala Val Glu Glu Thr Pro Lys Gln Glu Glu
Ser Thr Pro Asp 130 135 140Thr Lys Ala Glu Glu Thr Val Glu Pro Lys
Glu Glu Thr Val Asn Gln145 150 155 160Ser Ile Glu Gln Pro Lys Val
Glu Thr Pro Ala Val Glu Lys Gln Thr 165 170 175Glu Pro Thr Glu Glu
Pro Lys Val Glu Gln Ala Gly Glu Pro Val Ala 180 185 190Pro Arg Glu
Asp Glu Gln Ala Pro Thr Ala Pro Val Glu Pro Glu Lys 195 200 205Gln
Pro Glu Val Pro Glu Glu Glu Lys Ala Val Glu Glu Thr Pro Lys 210 215
220Pro Glu Asp Lys Ile Lys Gly Ile Gly Thr Lys Glu Pro Val Asp
Lys225 230 235 240Ser Glu Leu Asn Asn Gln Ile Asp Lys Ala Ser Ser
Val Ser Pro Thr 245 250 255Asp Tyr91199DNAStreptococcus pneumoniae
91ggatgctcaa gaaactgcgg gagttcacta taaatatgtg gcagattcag agctatcatc
60agaagaaaag aagcagcttg tctatgatat tccgacatac gtggagaatg atgatgaaac
120ttattatctt gtttataagt taaattctca aaatcaactg gcggaattgc
caaatactgg 180aagcaagaat gagaggcaa 1999266PRTStreptococcus
pneumoniae 92Asp Ala Gln Glu Thr Ala Gly Val His Tyr Lys Tyr Val
Ala Asp Ser1 5 10 15Glu Leu Ser Ser Glu Glu Lys Lys Gln Leu Val Tyr
Asp Ile Pro Thr 20 25 30Tyr Val Glu Asn Asp Asp Glu Thr Tyr Tyr Leu
Val Tyr Lys Leu Asn 35 40 45Ser Gln Asn Gln Leu Ala Glu Leu Pro Asn
Thr Gly Ser Lys Asn Glu 50 55 60Arg Gln6593835DNAStreptococcus
pneumoniae 93cgacaaaggt gagactgagg ttcaaccaga gtcgccagat actgtggtaa
gtgataaagg 60tgaaccagag caggtagcac cgcttccaga atataagggt aatattgagc
aagtaaaacc 120tgaaactccg gttgagaaga ccaaagaaca aggtccagaa
aaaactgaag aagttccagt 180aaaaccaaca gaagaaacac cagtaaatcc
aaatgaaggt actacagaag gaacctcaat 240tcaagaagca gaaaatccag
ttcaacctgc agaagaatca acaacgaatt cagagaaagt 300atcaccagat
acatctagca aaaatactgg ggaagtgtcc agtaatccta gtgattcgac
360aacctcagtt ggagaatcaa ataaaccaga acataatgac tctaaaaatg
aaaattcaga 420aaaaactgta gaagaagttc cagtaaatcc aaatgaaggc
acagtagaag gtacctcaaa 480tcaagaaaca gaaaaaccag ttcaacctgc
agaagaaaca caaacaaact ctgggaaaat 540agctaacgaa aatactggag
aagtatccaa taaacctagt gattcaaaac caccagttga 600agaatcaaat
caaccagaaa aaaacggaac tgcaacaaaa ccagaaaatt caggtaatac
660aacatcagag aatggacaaa cagaaccaga accatcaaac ggaaattcaa
ctgaggatgt 720ttcaaccgaa tcaaacacat ccaattcaaa tggaaacgaa
gaaattaaac aagaaaatga 780actagaccct gataaaaagg tagaagaacc
agagaaaaca cttgaattaa gaaat 83594278PRTStreptococcus pneumoniae
94Asp Lys Gly Glu Thr Glu Val Gln Pro Glu Ser Pro Asp Thr Val Val1
5 10 15Ser Asp Lys Gly Glu Pro Glu Gln Val Ala Pro Leu Pro Glu Tyr
Lys 20 25 30Gly Asn Ile Glu Gln Val Lys Pro Glu Thr Pro Val Glu Lys
Thr Lys 35 40 45Glu Gln Gly Pro Glu Lys Thr Glu Glu Val Pro Val Lys
Pro Thr Glu 50 55 60Glu Thr Pro Val Asn Pro Asn Glu Gly Thr Thr Glu
Gly Thr Ser Ile65 70 75 80Gln Glu Ala Glu Asn Pro Val Gln Pro Ala
Glu Glu Ser Thr Thr Asn 85 90 95Ser Glu Lys Val Ser Pro Asp Thr Ser
Ser Lys Asn Thr Gly Glu Val 100 105 110Ser Ser Asn Pro Ser Asp Ser
Thr Thr Ser Val Gly Glu Ser Asn Lys 115 120 125Pro Glu His Asn Asp
Ser Lys Asn Glu Asn Ser Glu Lys Thr Val Glu 130 135 140Glu Val Pro
Val Asn Pro Asn Glu Gly Thr Val Glu Gly Thr Ser Asn145 150 155
160Gln Glu Thr Glu Lys Pro Val Gln Pro Ala Glu Glu Thr Gln Thr Asn
165 170 175Ser Gly Lys Ile Ala Asn Glu Asn Thr Gly Glu Val Ser Asn
Lys Pro 180 185 190Ser Asp Ser Lys Pro Pro Val Glu Glu Ser Asn Gln
Pro Glu Lys Asn 195 200 205Gly Thr Ala Thr Lys Pro Glu Asn Ser Gly
Asn Thr Thr Ser Glu Asn 210 215 220Gly Gln Thr Glu Pro Glu Pro Ser
Asn Gly Asn Ser Thr Glu Asp Val225 230 235 240Ser Thr Glu Ser Asn
Thr Ser Asn Ser Asn Gly Asn Glu Glu Ile Lys 245 250 255Gln Glu Asn
Glu Leu Asp Pro Asp Lys Lys Val Glu Glu Pro Glu Lys 260 265 270Thr
Leu Glu Leu Arg Asn 27595709DNAStreptococcus pneumoniae
95aaatcaattg gtagcacaag atccaaaagc acaagatagc actaaactga ctgctgaaaa
60atcaactgtt aaagcacctg ctcaaagagt agatgtaaaa gatataactc atttaacaga
120tgaagaaaaa gttaaggttg ctattttaca agcaaatggt tcagcattag
acggagcgac 180aatcaatgta gctggagatg gtacagcaac aatcacattc
ccagatggtt cagtagtgac 240gattctagga aaagatacag ttcaacaatc
tgcgaaaggt gaatctgtaa ctcaagaagc 300tacaccagag tataagctag
aaaatacacc aggtggagat aagggaggca atactggaag 360ctcagatgct
aatgcgaatg aaggcggtgg tagccaggcg ggtggatcag ctcacacagg
420ttcacaaaac tcagctcaat cacaagcttc taagcaatta gctactgaaa
aagaatcagc 480taaaaatgcc attgaaaaag cagccaagga caagcaggat
gaaatcaaag gcgcaccgct 540ttctgataaa gaaaaagcag aacttttagc
aagagtggaa gcagaaaaac aagcagctct 600caaagagatt gaaaatgcga
aaactatgga agatgtgaag gaagcagaaa cgattggagt 660gcaagccatt
gccatggtta cagttcctaa gagaccagtg gctcctaat 70996236PRTStreptococcus
pneumoniae 96Asn Gln Leu Val Ala Gln Asp Pro Lys Ala Gln Asp Ser
Thr Lys Leu1 5 10 15Thr Ala Glu Lys Ser Thr Val Lys Ala Pro Ala Gln
Arg Val Asp Val 20 25 30Lys Asp Ile Thr His Leu Thr Asp Glu Glu Lys
Val Lys Val Ala Ile 35 40 45Leu Gln Ala Asn Gly Ser Ala Leu Asp Gly
Ala Thr Ile Asn Val Ala 50 55 60Gly Asp Gly Thr Ala Thr Ile Thr Phe
Pro Asp Gly Ser Val Val Thr65 70 75 80Ile Leu Gly Lys Asp Thr Val
Gln Gln Ser Ala Lys Gly Glu Ser Val 85 90 95Thr Gln Glu Ala Thr Pro
Glu Tyr Lys Leu Glu Asn Thr Pro Gly Gly 100 105 110Asp Lys Gly Gly
Asn Thr Gly Ser Ser Asp Ala Asn Ala Asn Glu Gly 115 120 125Gly Gly
Ser Gln Ala Gly Gly Ser Ala His Thr Gly Ser Gln Asn Ser 130 135
140Ala Gln Ser Gln Ala Ser Lys Gln Leu Ala Thr Glu Lys Glu Ser
Ala145 150 155 160Lys Asn Ala Ile Glu Lys Ala Ala Lys Asp Lys Gln
Asp Glu Ile Lys 165 170 175Gly Ala Pro Leu Ser Asp Lys Glu Lys Ala
Glu Leu Leu Ala Arg Val 180 185 190Glu Ala Glu Lys Gln Ala Ala Leu
Lys Glu Ile Glu Asn Ala Lys Thr 195 200 205Met Glu Asp Val Lys Glu
Ala Glu Thr Ile Gly Val Gln Ala Ile Ala 210 215 220Met Val Thr Val
Pro Lys Arg Pro Val Ala Pro Asn225 230 23597787DNAStreptococcus
pneumoniae 97caaacagtca gcttcaggaa cgattgaggt gatttcacga gaaaatggct
ctgggacacg 60gggtgccttc acagaaatca cagggattct caaaaaagac ggtgataaaa
aaattgacaa 120cactgccaaa acagctgtga ttcaaaatag tacagaaggt
gttctctcag cagttcaagg 180gaatgctaat gctatcggct acatctcctt
gggatcttta acgaaatctg tcaaggcttt 240agagattgat ggtgtcaagg
ctagtcgaga cacagtttta gatggtgaat accctcttca 300acgtcccttc
aacattgttt ggtcttctaa tctttccaag ctaggtcaag attttatcag
360ctttatccac tccaaacaag gtcaacaagt ggtcacagat aataaattta
ttgaagctaa 420aaccgaaacc acggaatata caagccaaca cttatcaggc
aagttgtctg ttgtaggttc 480cacttcagta tcttctttaa tggaaaaatt
agcagaagct tataaaaaag aaaatccaga 540agttacgatt gatattacct
ctaatgggtc ttcagcaggt attaccgctg ttaaggagaa 600aaccgctgat
attggtatgg tttctaggga attaactcct gaagaaggta agagtctcac
660ccatgatgct attgctttag acggtattgc tgttgtggtc aataatgaca
ataaggcaag 720ccaagtcagt atggctgaac ttgcagacgt ttttagtggc
aaattaacca cctgggacaa 780gattaaa 78798262PRTStreptococcus
pneumoniae 98Lys Gln Ser Ala Ser Gly Thr Ile Glu Val Ile Ser Arg
Glu Asn Gly1 5 10 15Ser Gly Thr Arg Gly Ala Phe Thr Glu Ile Thr
Gly
Ile Leu Lys Lys 20 25 30Asp Gly Asp Lys Lys Ile Asp Asn Thr Ala Lys
Thr Ala Val Ile Gln 35 40 45Asn Ser Thr Glu Gly Val Leu Ser Ala Val
Gln Gly Asn Ala Asn Ala 50 55 60Ile Gly Tyr Ile Ser Leu Gly Ser Leu
Thr Lys Ser Val Lys Ala Leu65 70 75 80Glu Ile Asp Gly Val Lys Ala
Ser Arg Asp Thr Val Leu Asp Gly Glu 85 90 95Tyr Pro Leu Gln Arg Pro
Phe Asn Ile Val Trp Ser Ser Asn Leu Ser 100 105 110Lys Leu Gly Gln
Asp Phe Ile Ser Phe Ile His Ser Lys Gln Gly Gln 115 120 125Gln Val
Val Thr Asp Asn Lys Phe Ile Glu Ala Lys Thr Glu Thr Thr 130 135
140Glu Tyr Thr Ser Gln His Leu Ser Gly Lys Leu Ser Val Val Gly
Ser145 150 155 160Thr Ser Val Ser Ser Leu Met Glu Lys Leu Ala Glu
Ala Tyr Lys Lys 165 170 175Glu Asn Pro Glu Val Thr Ile Asp Ile Thr
Ser Asn Gly Ser Ser Ala 180 185 190Gly Ile Thr Ala Val Lys Glu Lys
Thr Ala Asp Ile Gly Met Val Ser 195 200 205Arg Glu Leu Thr Pro Glu
Glu Gly Lys Ser Leu Thr His Asp Ala Ile 210 215 220Ala Leu Asp Gly
Ile Ala Val Val Val Asn Asn Asp Asn Lys Ala Ser225 230 235 240Gln
Val Ser Met Ala Glu Leu Ala Asp Val Phe Ser Gly Lys Leu Thr 245 250
255Thr Trp Asp Lys Ile Lys 26099421DNAStreptococcus pneumoniae
99attcgatgat gcggatgaaa agatgacccg tgatgaaatt gcctatatgc tgacaaatag
60tgaagaaaca ttggatgctg atgagattga gatgctacaa ggtgtctttt cgctcgatga
120actgatggca cgagaggtta tggttcctcg aacggatgcc tttatggtgg
atattcagga 180tgatagtcaa gccattatcc aaagtatttt aaaacaaaat
tattctcgta tcccggttta 240tgatggggat aaggacaatg taattggaat
cattcacacc aagagtctcc ttaaggcagg 300ctttgtggac ggttttgaca
atattgtttg gaagagaatt ttacaagatc cactttttgt 360acctgaaact
atttttgtgg atgacttgct aaaagaactg cgaaataccc aaagacaaat 420g
421100140PRTStreptococcus pneumoniae 100Phe Asp Asp Ala Asp Glu Lys
Met Thr Arg Asp Glu Ile Ala Tyr Met1 5 10 15Leu Thr Asn Ser Glu Glu
Thr Leu Asp Ala Asp Glu Ile Glu Met Leu 20 25 30Gln Gly Val Phe Ser
Leu Asp Glu Leu Met Ala Arg Glu Val Met Val 35 40 45Pro Arg Thr Asp
Ala Phe Met Val Asp Ile Gln Asp Asp Ser Gln Ala 50 55 60Ile Ile Gln
Ser Ile Leu Lys Gln Asn Tyr Ser Arg Ile Pro Val Tyr65 70 75 80Asp
Gly Asp Lys Asp Asn Val Ile Gly Ile Ile His Thr Lys Ser Leu 85 90
95Leu Lys Ala Gly Phe Val Asp Gly Phe Asp Asn Ile Val Trp Lys Arg
100 105 110Ile Leu Gln Asp Pro Leu Phe Val Pro Glu Thr Ile Phe Val
Asp Asp 115 120 125Leu Leu Lys Glu Leu Arg Asn Thr Gln Arg Gln Met
130 135 140101331DNAStreptococcus pneumoniae 101ggagagtcga
tcaaaagtag atgaagctgt gtctaagttt gaaaaggact catcttcttc 60gtcaagttca
gactcttcca ctaaaccgga agcttcagat acagcgaagc caaacaagcc
120gacagaacca ggagaaaagg tagcagaagc taagaagaag gttgaagaag
ctgagaaaaa 180agccaaggat caaaaagaag aagatcgtcg taactaccca
accattactt acaaaacgct 240tgaacttgaa attgctgagt ccgatgtgga
agttaaaaaa gcggagcttg aactagtaaa 300agtgaaagct aacgaacctc
gagacgagca a 331102110PRTStreptococcus pneumoniae 102Glu Ser Arg
Ser Lys Val Asp Glu Ala Val Ser Lys Phe Glu Lys Asp1 5 10 15Ser Ser
Ser Ser Ser Ser Ser Asp Ser Ser Thr Lys Pro Glu Ala Ser 20 25 30Asp
Thr Ala Lys Pro Asn Lys Pro Thr Glu Pro Gly Glu Lys Val Ala 35 40
45Glu Ala Lys Lys Lys Val Glu Glu Ala Glu Lys Lys Ala Lys Asp Gln
50 55 60Lys Glu Glu Asp Arg Arg Asn Tyr Pro Thr Ile Thr Tyr Lys Thr
Leu65 70 75 80Glu Leu Glu Ile Ala Glu Ser Asp Val Glu Val Lys Lys
Ala Glu Leu 85 90 95Glu Leu Val Lys Val Lys Ala Asn Glu Pro Arg Asp
Glu Gln 100 105 110103358DNAStreptococcus pneumoniae 103atggacaaca
ggaaactggg acgaggttat atctggtaag attgacaagt acaaagatcc 60agatattcca
acagttgaat cacaagaagt tacgtcagac tctagtgata aagaaataac
120ggtaaggtat gaccgtttat caacaccaga aaaaccaatc ccacaaccaa
atccagagca 180tccaagtgtt ccgacaccaa acccagaact accaaatcaa
gagactccaa caccagataa 240accaactcca gaaccaggta ctccaaaaac
tgaaactcca gtgaatccag acccagaagt 300tccgacttat gagacaggta
agagagagga attgccaaac acaggtacag aagctaat 358104119PRTStreptococcus
pneumoniae 104Trp Thr Thr Gly Asn Trp Asp Glu Val Ile Ser Gly Lys
Ile Asp Lys1 5 10 15Tyr Lys Asp Pro Asp Ile Pro Thr Val Glu Ser Gln
Glu Val Thr Ser 20 25 30Asp Ser Ser Asp Lys Glu Ile Thr Val Arg Tyr
Asp Arg Leu Ser Thr 35 40 45Pro Glu Lys Pro Ile Pro Gln Pro Asn Pro
Glu His Pro Ser Val Pro 50 55 60Thr Pro Asn Pro Glu Leu Pro Asn Gln
Glu Thr Pro Thr Pro Asp Lys65 70 75 80Pro Thr Pro Glu Pro Gly Thr
Pro Lys Thr Glu Thr Pro Val Asn Pro 85 90 95Asp Pro Glu Val Pro Thr
Tyr Glu Thr Gly Lys Arg Glu Glu Leu Pro 100 105 110Asn Thr Gly Thr
Glu Ala Asn 1151051879DNAStreptococcus
pneumoniaemisc_feature(1040)..(1040)n is a, c, g, or t
105cgatgggctc aatccaaccc caggtcaagt cttacctgaa gagacatcgg
gaacgaaaga 60gggtgactta tcagaaaaac caggagacac cgttctcact caagcgaaac
ctgagggcgt 120tactggaaat acgaattcac ttccgacacc tacagaaaga
actgaagtga gcgaggaaac 180aagcccttct agtctggata cactttttga
aaaagatgaa gaagctcaaa aaaatccaga 240gctaacagat gtcttaaaag
aaactgtaga tacagctgat gtggatggga cacaagcaag 300tccagcagaa
actactcctg aacaagtaaa aggtggagtg aaagaaaata caaaagacag
360catcgatgtt cctgctgctt atcttgaaaa agctgaaggg aaaggtcctt
tcactgccgg 420tgtaaaccaa gtaattcctt atgaactatt cgctggtgat
ggtatgttaa ctcgtctatt 480actaaaagct tcggataatg ctccttggtc
tgacaatggt actgctaaaa atcctgcttt 540acctcctctt gaaggattaa
caaaagggaa atacttctat gaagtagact taaatggcaa 600tactgttggt
aaacaaggtc aagctttaat tgatcaactt cgcgctaatg gtactcaaac
660ttataaagct actgttaaag tttacggaaa taaagacggt aaagctgact
tgactaatct 720agttgctact aaaaatgtag acatcaacat caatggatta
gttgctaaag aaacagttca 780aaaagccgtt gcagacaacg ttaaagacag
tatcgatgtt ccagcagcct acctagaaaa 840agccaagggt gaaggtccat
tcacagcagg tgtcaaccat gtgattccat acgaactctt 900cgcaggtgat
ggcatgttga ctcgtctctt gctcaaggca tctgacaagg caccatggtc
960agataacggc gacgctaaaa acccagccct atctccacta ggcgaaaacg
tgaagaccaa 1020aggtcaatac ttctatcaan tagccttgga cggaaatgta
gctggcaaag aaaaacaagc 1080gctcattgac cagttccgag caaanggtac
tcaaacttac agcgctacag tcaatgtcta 1140tggtaacaaa gacggtaaac
cagacttgga caacatcgta gcaactaaaa aagtcactat 1200taacataaac
ggtttaattt ctaaagaaac agttcaaaaa gccgttgcag acaacgttaa
1260ngacagtatc gatgttccag cagcctacct agaaaaagcc aagggtgaag
gtccattcac 1320agcaggtgtc aaccatgtga ttccatacga actcttcgca
ggtgatggta tgttgactcg 1380tctcttgctc aaggcatctg acaaggcacc
atggtcagat aacggngacg ctaaaaaccc 1440agcnctatct ccactaggtg
aaaacgtgaa gaccaaaggt caatacttct atcaantagc 1500cttggacgga
aatgtagctg gcaaagaaaa acaagcgctc attgaccagt tccgagcaaa
1560cggtactcaa acttacagcg ctacagtcaa tgtctatggt aacaaagacg
gtaaaccaga 1620cttggacaac atcgtagcaa ctaaaaaagt cactattaag
ataaatgtta aagaaacatc 1680agacacagca aatggttcat tatcaccttc
taactctggt tctggcgtga ctccgatgaa 1740tcacaatcat gctacaggta
ctacagatag catgcctgct gacaccatga caagttctac 1800caacacgatg
gcaggtgaaa acatggctgc ttctgctaac aagatgtctg atacgatgat
1860gtcagaggat aaagctatg 1879106626PRTStreptococcus
pneumoniaeSITE(347)..(347)Xaa can be any naturally occurring amino
acid 106Asp Gly Leu Asn Pro Thr Pro Gly Gln Val Leu Pro Glu Glu Thr
Ser1 5 10 15Gly Thr Lys Glu Gly Asp Leu Ser Glu Lys Pro Gly Asp Thr
Val Leu 20 25 30Thr Gln Ala Lys Pro Glu Gly Val Thr Gly Asn Thr Asn
Ser Leu Pro 35 40 45Thr Pro Thr Glu Arg Thr Glu Val Ser Glu Glu Thr
Ser Pro Ser Ser 50 55 60Leu Asp Thr Leu Phe Glu Lys Asp Glu Glu Ala
Gln Lys Asn Pro Glu65 70 75 80Leu Thr Asp Val Leu Lys Glu Thr Val
Asp Thr Ala Asp Val Asp Gly 85 90 95Thr Gln Ala Ser Pro Ala Glu Thr
Thr Pro Glu Gln Val Lys Gly Gly 100 105 110Val Lys Glu Asn Thr Lys
Asp Ser Ile Asp Val Pro Ala Ala Tyr Leu 115 120 125Glu Lys Ala Glu
Gly Lys Gly Pro Phe Thr Ala Gly Val Asn Gln Val 130 135 140Ile Pro
Tyr Glu Leu Phe Ala Gly Asp Gly Met Leu Thr Arg Leu Leu145 150 155
160Leu Lys Ala Ser Asp Asn Ala Pro Trp Ser Asp Asn Gly Thr Ala Lys
165 170 175Asn Pro Ala Leu Pro Pro Leu Glu Gly Leu Thr Lys Gly Lys
Tyr Phe 180 185 190Tyr Glu Val Asp Leu Asn Gly Asn Thr Val Gly Lys
Gln Gly Gln Ala 195 200 205Leu Ile Asp Gln Leu Arg Ala Asn Gly Thr
Gln Thr Tyr Lys Ala Thr 210 215 220Val Lys Val Tyr Gly Asn Lys Asp
Gly Lys Ala Asp Leu Thr Asn Leu225 230 235 240Val Ala Thr Lys Asn
Val Asp Ile Asn Ile Asn Gly Leu Val Ala Lys 245 250 255Glu Thr Val
Gln Lys Ala Val Ala Asp Asn Val Lys Asp Ser Ile Asp 260 265 270Val
Pro Ala Ala Tyr Leu Glu Lys Ala Lys Gly Glu Gly Pro Phe Thr 275 280
285Ala Gly Val Asn His Val Ile Pro Tyr Glu Leu Phe Ala Gly Asp Gly
290 295 300Met Leu Thr Arg Leu Leu Leu Lys Ala Ser Asp Lys Ala Pro
Trp Ser305 310 315 320Asp Asn Gly Asp Ala Lys Asn Pro Ala Leu Ser
Pro Leu Gly Glu Asn 325 330 335Val Lys Thr Lys Gly Gln Tyr Phe Tyr
Gln Xaa Ala Leu Asp Gly Asn 340 345 350Val Ala Gly Lys Glu Lys Gln
Ala Leu Ile Asp Gln Phe Arg Ala Xaa 355 360 365Gly Thr Gln Thr Tyr
Ser Ala Thr Val Asn Val Tyr Gly Asn Lys Asp 370 375 380Gly Lys Pro
Asp Leu Asp Asn Ile Val Ala Thr Lys Lys Val Thr Ile385 390 395
400Asn Ile Asn Gly Leu Ile Ser Lys Glu Thr Val Gln Lys Ala Val Ala
405 410 415Asp Asn Val Xaa Asp Ser Ile Asp Val Pro Ala Ala Tyr Leu
Glu Lys 420 425 430Ala Lys Gly Glu Gly Pro Phe Thr Ala Gly Val Asn
His Val Ile Pro 435 440 445Tyr Glu Leu Phe Ala Gly Asp Gly Met Leu
Thr Arg Leu Leu Leu Lys 450 455 460Ala Ser Asp Lys Ala Pro Trp Ser
Asp Asn Gly Asp Ala Lys Asn Pro465 470 475 480Ala Leu Ser Pro Leu
Gly Glu Asn Val Lys Thr Lys Gly Gln Tyr Phe 485 490 495Tyr Gln Xaa
Ala Leu Asp Gly Asn Val Ala Gly Lys Glu Lys Gln Ala 500 505 510Leu
Ile Asp Gln Phe Arg Ala Asn Gly Thr Gln Thr Tyr Ser Ala Thr 515 520
525Val Asn Val Tyr Gly Asn Lys Asp Gly Lys Pro Asp Leu Asp Asn Ile
530 535 540Val Ala Thr Lys Lys Val Thr Ile Lys Ile Asn Val Lys Glu
Thr Ser545 550 555 560Asp Thr Ala Asn Gly Ser Leu Ser Pro Ser Asn
Ser Gly Ser Gly Val 565 570 575Thr Pro Met Asn His Asn His Ala Thr
Gly Thr Thr Asp Ser Met Pro 580 585 590Ala Asp Thr Met Thr Ser Ser
Thr Asn Thr Met Ala Gly Glu Asn Met 595 600 605Ala Ala Ser Ala Asn
Lys Met Ser Asp Thr Met Met Ser Glu Asp Lys 610 615 620Ala
Met625107593DNAStreptococcus pneumoniae 107ttccaatcaa aaacaggcag
atggtaaact caatatcgtg acaacctttt accctgtcta 60tgartttacc aagcaagtcg
caggagatac ggctaatgta gaactcctaa tcggtgctgg 120gacagaacct
catgaatacg aaccatctgc caaggcagtt gccaaaatcc aagatgcaga
180taccttcgtt tatgaaaatg aaaacatgga aacatgggta cctaaattgc
tagatacctt 240ggataagaaa aaagtgaaaa ccatcaaggc gacaggcgat
atgttgctct tgccaggtgg 300cgaggaagaa gagggagacc atgaccatgg
agaagaaggt catcaccatg agtttgaccc 360ccatgtttgg ttatcaccag
ttcgtgccat taaactagta gagcaccatc cgcgacactt 420gtcagcagat
tatcctgata aaaaagagac ctttgagaag aatgcagctg cctatatcga
480aaaattgcaa gccttggata aggcttacgc agaaggtttg tctcaagcaa
aacaaaagag 540ctttgtgact caacacgcag cctttaacta tcttgccttg
gactatggga ctc 593108197PRTStreptococcus pneumoniae 108Ser Asn Gln
Lys Gln Ala Asp Gly Lys Leu Asn Ile Val Thr Thr Phe1 5 10 15Tyr Pro
Val Tyr Glu Phe Thr Lys Gln Val Ala Gly Asp Thr Ala Asn 20 25 30Val
Glu Leu Leu Ile Gly Ala Gly Thr Glu Pro His Glu Tyr Glu Pro 35 40
45Ser Ala Lys Ala Val Ala Lys Ile Gln Asp Ala Asp Thr Phe Val Tyr
50 55 60Glu Asn Glu Asn Met Glu Thr Trp Val Pro Lys Leu Leu Asp Thr
Leu65 70 75 80Asp Lys Lys Lys Val Lys Thr Ile Lys Ala Thr Gly Asp
Met Leu Leu 85 90 95Leu Pro Gly Gly Glu Glu Glu Glu Gly Asp His Asp
His Gly Glu Glu 100 105 110Gly His His His Glu Phe Asp Pro His Val
Trp Leu Ser Pro Val Arg 115 120 125Ala Ile Lys Leu Val Glu His His
Pro Arg His Leu Ser Ala Asp Tyr 130 135 140Pro Asp Lys Lys Glu Thr
Phe Glu Lys Asn Ala Ala Ala Tyr Ile Glu145 150 155 160Lys Leu Gln
Ala Leu Asp Lys Ala Tyr Ala Glu Gly Leu Ser Gln Ala 165 170 175Lys
Gln Lys Ser Phe Val Thr Gln His Ala Ala Phe Asn Tyr Leu Ala 180 185
190Leu Asp Tyr Gly Thr 1951091003DNAStreptococcus pneumoniae
109tatcacagga tcgaacggta agacaaccac aacgactatg attggggaag
ttttgactgc 60tgctggccaa catggtcttt tatcagggaa tatcggctat ccagctagtc
aggttgctca 120aatagcatca gataaggaca cgcttgttat ggaactttct
tctttccaac tcatgggtgt 180tcaagaattc catccagaga ttgcggttat
taccaacctc atgccaactc atatcgacta 240ccatgggtca ttttcggaat
atgtagcagc caagtggaat atccagaaca agatgacagc 300agctgatttc
cttgtcttga actttaatca agacttggca aaagacttga cttccaagac
360agaagccact gttgtaccat tttcaacact tgaaaaggtt gatggagctt
atctggaaga 420tggtcaactc tacttccgtg gtgaagtagt catggcagcg
aatgaaatcg gtgttccagg 480tagccacaat gtggaaaatg cccttgcgac
tattgctgta gccaagcttc gtgatgtgga 540caatcaaacc atcaaggaaa
ctctttcagc cttcggtggt gtcaaacacc gtctccagtt 600tgtggatgac
atcaagggtg ttaaattcta taacgacagt aaatcaacta atatcttggc
660tactcaaaaa gccttgtcag gatttgacaa cagcaaggtc gtcttgattg
caggtggttt 720ggaccgtggc aatgagtttg acgaattggt gccagacatt
actggactca agaagatggt 780catcctgggt caatctgcag aacgtgtcaa
acgggcagca gacaaggctg gtgtcgctta 840tgtggaggcg acagatattg
cagatgcgac ccgcaaggcc tatgagcttg cgactcaagg 900agatgtggtt
cttcttagtc ctgccaatgc tagctgggat atgtatgcta actttgaagt
960acgtggcgac ctctttatcg acacagtagc ggagttaaaa gaa
1003110335PRTStreptococcus pneumoniae 110Gly Ile Thr Gly Ser Asn
Gly Lys Thr Thr Thr Thr Thr Met Ile Gly1 5 10 15Glu Val Leu Thr Ala
Ala Gly Gln His Gly Leu Leu Ser Gly Asn Ile 20 25 30Gly Tyr Pro Ala
Ser Gln Val Ala Gln Ile Ala Ser Asp Lys Asp Thr 35 40 45Leu Val Met
Glu Leu Ser Ser Phe Gln Leu Met Gly Val Gln Glu Phe 50 55 60His Pro
Glu Ile Ala Val Ile Thr Asn Leu Met Pro Thr His Ile Asp65 70 75
80Tyr His Gly Ser Phe Ser Glu Tyr Val Ala Ala Lys Trp Asn Ile Gln
85 90 95Asn Lys Met Thr Ala Ala Asp Phe Leu Val Leu Asn Phe Asn Gln
Asp 100 105 110Leu Ala Lys Asp Leu Thr Ser Lys Thr Glu Ala Thr Val
Val Pro Phe 115 120 125Ser Thr Leu Glu Lys Val Asp Gly Ala Tyr Leu
Glu Asp Gly Gln Leu 130 135 140Tyr Phe Arg Gly Glu Val Val Met Ala
Ala Asn Glu Ile Gly Val Pro145 150 155 160Gly Ser His Asn Val Glu
Asn Ala Leu Ala Thr Ile Ala Val Ala Lys 165 170 175Leu Arg Asp Val
Asp Asn Gln Thr Ile Lys Glu Thr Leu Ser Ala Phe 180 185
190Gly Gly Val Lys His Arg Leu Gln Phe Val Asp Asp Ile Lys Gly Val
195 200 205Lys Phe Tyr Asn Asp Ser Lys Ser Thr Asn Ile Leu Ala Thr
Gln Lys 210 215 220Ala Leu Ser Gly Phe Asp Asn Ser Lys Val Val Leu
Ile Ala Gly Gly225 230 235 240Leu Asp Arg Gly Asn Glu Phe Asp Glu
Leu Val Pro Asp Ile Thr Gly 245 250 255Leu Lys Lys Met Val Ile Leu
Gly Gln Ser Ala Glu Arg Val Lys Arg 260 265 270Ala Ala Asp Lys Ala
Gly Val Ala Tyr Val Glu Ala Thr Asp Ile Ala 275 280 285Asp Ala Thr
Arg Lys Ala Tyr Glu Leu Ala Thr Gln Gly Asp Val Val 290 295 300Leu
Leu Ser Pro Ala Asn Ala Ser Trp Asp Met Tyr Ala Asn Phe Glu305 310
315 320Val Arg Gly Asp Leu Phe Ile Asp Thr Val Ala Glu Leu Lys Glu
325 330 335111412DNAStreptococcus pneumoniae 111aagttcatcg
aagatggttg ggaagtccac tatatcgggg acaagtgtgg tatcgaacac 60caagaaatcc
ttaagtcagg tttggatgtc accttccatt ctattgcgac tggaaaattg
120cgtcgctatt tctcttggca aaatatgctg gacgtcttca aagttggttg
gggaattgtc 180caatcgctct ttatcatgtt gcgactgcgt ccacagaccc
ttttttcaaa ggggggcttt 240gtctcagtac cgcctgttat cgctgcgcgt
gtgtcaggag tgcctgtctt tattcacgaa 300tctgacctgt ctatgggctt
ggccaataaa atcgcctata aatttgcgac taagatgtat 360tcaacctttg
aacaagcttc gagtttggct aaggttgagc atgtgggagc gg
412112137PRTStreptococcus pneumoniae 112Ser Ser Ser Lys Met Val Gly
Lys Ser Thr Ile Ser Gly Thr Ser Val1 5 10 15Val Ser Asn Thr Lys Lys
Ser Leu Ser Gln Val Trp Met Ser Pro Ser 20 25 30Ile Leu Leu Arg Leu
Glu Asn Cys Val Ala Ile Ser Leu Gly Lys Ile 35 40 45Cys Trp Thr Ser
Ser Lys Leu Val Gly Glu Leu Ser Asn Arg Ser Leu 50 55 60Ser Cys Cys
Asp Cys Val His Arg Pro Phe Phe Gln Arg Gly Ala Leu65 70 75 80Ser
Gln Tyr Arg Leu Leu Ser Leu Arg Val Cys Gln Glu Cys Leu Ser 85 90
95Leu Phe Thr Asn Leu Thr Cys Leu Trp Ala Trp Pro Ile Lys Ser Pro
100 105 110Ile Asn Leu Arg Leu Arg Cys Ile Gln Pro Leu Asn Lys Leu
Arg Val 115 120 125Trp Leu Arg Leu Ser Met Trp Glu Arg 130
135113544DNAStreptococcus pneumoniae 113atcgctagct agtgaaatgc
aagaaagtac acgtaaattc aaggttactg ctgacctaac 60agatgccggt gttggaacga
ttgaagttcc tttgagcatt gaagatttac ccaatgggct 120gaccgctgtg
gcgactccgc aaaaaattac agtcaagatt ggtaagaagg ctcagaagga
180taaggtaaag attgtaccag agattgaccc tagtcaaatt gatagtcggg
tacaaattga 240aaatgtcatg gtgtcagata aagaagtgtc tattacgagt
gaccaagaga cattggatag 300aattgataag attatcgctg ttttgccaac
tagcgaacgt ataacaggta attacagtgg 360ttcagtacct ttgcaggcaa
tcgaccgcaa tggtgttgtc ttaccggcag ttatcactcc 420gtttgataca
ataatgaagg tgactacaaa accagtagca ccaagttcaa gcacatcaaa
480ttcaagtaca agcagttcat cggagacatc ttcgtcaacg aaagcaacta
gttcaaaaac 540gaat 544114181PRTStreptococcus pneumoniae 114Ser Leu
Ala Ser Glu Met Gln Glu Ser Thr Arg Lys Phe Lys Val Thr1 5 10 15Ala
Asp Leu Thr Asp Ala Gly Val Gly Thr Ile Glu Val Pro Leu Ser 20 25
30Ile Glu Asp Leu Pro Asn Gly Leu Thr Ala Val Ala Thr Pro Gln Lys
35 40 45Ile Thr Val Lys Ile Gly Lys Lys Ala Gln Lys Asp Lys Val Lys
Ile 50 55 60Val Pro Glu Ile Asp Pro Ser Gln Ile Asp Ser Arg Val Gln
Ile Glu65 70 75 80Asn Val Met Val Ser Asp Lys Glu Val Ser Ile Thr
Ser Asp Gln Glu 85 90 95Thr Leu Asp Arg Ile Asp Lys Ile Ile Ala Val
Leu Pro Thr Ser Glu 100 105 110Arg Ile Thr Gly Asn Tyr Ser Gly Ser
Val Pro Leu Gln Ala Ile Asp 115 120 125Arg Asn Gly Val Val Leu Pro
Ala Val Ile Thr Pro Phe Asp Thr Ile 130 135 140Met Lys Val Thr Thr
Lys Pro Val Ala Pro Ser Ser Ser Thr Ser Asn145 150 155 160Ser Ser
Thr Ser Ser Ser Ser Glu Thr Ser Ser Ser Thr Lys Ala Thr 165 170
175Ser Ser Lys Thr Asn 1801151267DNAStreptococcus pneumoniae
115gcaccagatg gggcacaagg ttcagggatc agatgttgaa aagtactact
ttacccaacg 60cggtcttgag caggcaggaa ttaccattct tccttttgat gaaaaaaatc
tagacggtga 120tatggaaatt atcgctggaa atgcctttcg tccagataac
aacgtcgaaa ttgcctatgc 180ggaccaaaat ggtatcagct acaaacgtta
ccatgagttt ctaggtagct ttatgcgtga 240ctttgttagc atgggagtag
caggagcaca tggaaaaact tcaacgacag gtatgttgtc 300tcatgtcttg
tctcacatta cagataccag cttcttgatt ggagatggga caggtcgtgg
360ttcggccaat gccaaatatt ttgtctttga atctgacgaa tatgagcgtc
acttcatgcc 420ttaccaccca gaatactcta ttatcaccaa cattgacttt
gaccatccag attatttcac 480aagtctcgag gatgttttta atgcctttaa
cgactatgcc aaacaaatca ccaagggtct 540ttttgtctat ggtgaagatg
ctgaattgcg taagattacg tctgatgcac caatttatta 600ttatggtttt
gaagctgaag gcaatgactt tgtagctagt gatcttcttc gttcaataac
660tggttcaacc ttcaccgttc atttccgtgg acaaaacttg gggcaattcc
acattccaac 720ctttggtcgt cacaatatca tgaatgcgac agccgttatt
ggtcttcttt acacagcagg 780atttgatttg aacttggtgc gtgagcactt
gaaaacattt gccggtgtta aacgtcgttt 840cactgagaaa attgtcaatg
atacagtgat tatcgatgac tttgcccacc atccaacaga 900aattattgcg
accttggatg cggctcgtca gaaataccca agcaaggaaa ttgtagcagt
960ctttcaaccg cataccttta caagaaccat tgccttgttg gacgactttg
cccatgcttt 1020aaaccaagca gatgctgttt atctagcgca aatttatggc
tcggctcgtg aagtagatca 1080tggtgacgtt aaggtagaag acctagccaa
caaaatcaac aaaaaacacc aagtgattac 1140tgttgaaaat gtttctccac
tcctagacca tgacaatgct gtttacgtct ttatgggagc 1200aggagacatc
caaacctatg aatactcatt tgagcgtctc ttgtctaact tgacaagcaa 1260tgttcaa
1267116422PRTStreptococcus pneumoniae 116His Gln Met Gly His Lys
Val Gln Gly Ser Asp Val Glu Lys Tyr Tyr1 5 10 15Phe Thr Gln Arg Gly
Leu Glu Gln Ala Gly Ile Thr Ile Leu Pro Phe 20 25 30Asp Glu Lys Asn
Leu Asp Gly Asp Met Glu Ile Ile Ala Gly Asn Ala 35 40 45Phe Arg Pro
Asp Asn Asn Val Glu Ile Ala Tyr Ala Asp Gln Asn Gly 50 55 60Ile Ser
Tyr Lys Arg Tyr His Glu Phe Leu Gly Ser Phe Met Arg Asp65 70 75
80Phe Val Ser Met Gly Val Ala Gly Ala His Gly Lys Thr Ser Thr Thr
85 90 95Gly Met Leu Ser His Val Leu Ser His Ile Thr Asp Thr Ser Phe
Leu 100 105 110Ile Gly Asp Gly Thr Gly Arg Gly Ser Ala Asn Ala Lys
Tyr Phe Val 115 120 125Phe Glu Ser Asp Glu Tyr Glu Arg His Phe Met
Pro Tyr His Pro Glu 130 135 140Tyr Ser Ile Ile Thr Asn Ile Asp Phe
Asp His Pro Asp Tyr Phe Thr145 150 155 160Ser Leu Glu Asp Val Phe
Asn Ala Phe Asn Asp Tyr Ala Lys Gln Ile 165 170 175Thr Lys Gly Leu
Phe Val Tyr Gly Glu Asp Ala Glu Leu Arg Lys Ile 180 185 190Thr Ser
Asp Ala Pro Ile Tyr Tyr Tyr Gly Phe Glu Ala Glu Gly Asn 195 200
205Asp Phe Val Ala Ser Asp Leu Leu Arg Ser Ile Thr Gly Ser Thr Phe
210 215 220Thr Val His Phe Arg Gly Gln Asn Leu Gly Gln Phe His Ile
Pro Thr225 230 235 240Phe Gly Arg His Asn Ile Met Asn Ala Thr Ala
Val Ile Gly Leu Leu 245 250 255Tyr Thr Ala Gly Phe Asp Leu Asn Leu
Val Arg Glu His Leu Lys Thr 260 265 270Phe Ala Gly Val Lys Arg Arg
Phe Thr Glu Lys Ile Val Asn Asp Thr 275 280 285Val Ile Ile Asp Asp
Phe Ala His His Pro Thr Glu Ile Ile Ala Thr 290 295 300Leu Asp Ala
Ala Arg Gln Lys Tyr Pro Ser Lys Glu Ile Val Ala Val305 310 315
320Phe Gln Pro His Thr Phe Thr Arg Thr Ile Ala Leu Leu Asp Asp Phe
325 330 335Ala His Ala Leu Asn Gln Ala Asp Ala Val Tyr Leu Ala Gln
Ile Tyr 340 345 350Gly Ser Ala Arg Glu Val Asp His Gly Asp Val Lys
Val Glu Asp Leu 355 360 365Ala Asn Lys Ile Asn Lys Lys His Gln Val
Ile Thr Val Glu Asn Val 370 375 380Ser Pro Leu Leu Asp His Asp Asn
Ala Val Tyr Val Phe Met Gly Ala385 390 395 400Gly Asp Ile Gln Thr
Tyr Glu Tyr Ser Phe Glu Arg Leu Leu Ser Asn 405 410 415Leu Thr Ser
Asn Val Gln 4201173121DNAStreptococcus pneumoniae 117ttttaaccca
actgttggta ctttcctttt tactgcagga ttgagcttgt tagttttatt 60ggtttctaaa
agggaaaatg gaaagaaacg acttgttcat tttctgctgt tgactagcat
120gggagttcaa ttgttgccgg ccagtgcttt tgggttgacc agccagattt
tatctgccta 180taatagtcag ctttctatcg gagtcgggga acatttacca
gagcctctga aaatcgaagg 240ttatcaatat attggttata tcaaaactaa
gaaacaggat aatacagagc tttcaaggac 300agttgatggg aaatactctg
ctcaaagaga tagtcaacca aactctacaa aaacatcaga 360tgtagttcat
tcagctgatt tagaatggaa ccaaggacag gggaaggtta gtttacaagg
420tgaagcatca ggggatgatg gactttcaga aaaatcttct atagcagcag
acaatctatc 480ttctaatgat tcattcgcaa gtcaagttga gcagaatccg
gatcacaaag gagaatctgt 540agttcgacca acagtgccag aacaaggaaa
tcctgtgtct gctacaacgg tgcagagtgc 600ggaagaggaa gtattggcga
cgacaaatga tcgaccagag tataaacttc cattggaaac 660caaaggcacg
caagaacccg gtcatgaggg tgaagccgca gtccgtgaag acttaccagt
720ctacactaag ccactagaaa ccaaaggtac acaaggaccc ggacatgaag
gtgaagctgc 780agttcgcgag gaagaaccag cttacacaga accgttagca
acgaaaggca cgcaagagcc 840aggtcatgag ggcaaagcta cagtccgcga
agagactcta gagtacacgg aaccggtagc 900gacaaaaggc acacaagaac
ccgaacatga gggcgaacgg scagtagaag aagaacttcc 960ggctttagag
gtcactacac gaaatagaac ggaaatccag aatattcctt atacaacaga
1020agaaattcag gatccaacac ttctgaaaaa tcgtcgtaag attgaacgac
aagggcaagc 1080agggacacgt acaattcaat atgaagacta catcgtaaat
ggtaatgtcg tagaaactaa 1140agaagtgtca cgaactgaag tagctccggt
caacgaagtc gttaaagtag gaacacttgt 1200gaaagttaaa cctacagtag
aaattacaaa cttaacaaaa gttgagaaca aaaaatctat 1260aactgtaagt
tataacttaa tagacactac ctcagcatat gtttctgcaa aaacgcaagt
1320tttccatgga gacaagctag ttaaagaggt ggatatagaa aatcctgcca
aagagcaagt 1380aatatcaggt ttagattact acacaccgta tacagttaaa
acacacctaa cttataattt 1440gggtgaaaat aatgaggaaa atactgaaac
atcaactcaa gatttccaat tagagtataa 1500gaaaatagag attaaagata
ttgattcagt agaattatac ggtaaagaaa atgatcgtta 1560tcgtagatat
ttaagtctaa gtgaagcgcc gactgatacg gctaaatact ttgtaaaagt
1620gaaatcagat cgcttcaaag aaatgtacct acctgtaaaa tctattacag
aaaatacgga 1680tggaacgtat aaagtgacgg tagccgttga tcaacttgtc
gaagaaggta cagacggtta 1740caaagatgat tacacattta ctgtagctaa
atctaaagca gagcaaccag gagtttacac 1800atcctttaaa cagctggtaa
cagccatgca aagcaatctg tctggtgtct atacattggc 1860ttcagatatg
accgcagatg aggtgagctt aggcgataag cagacaagtt atctcacagg
1920tgcatttaca gggagcttga tcggttctga tggaacaaaa tcgtatgcca
tttatgattt 1980gaagaaacca ttatttgata cattaaatgg tgctacagtt
agagatttgg atattaaaac 2040tgtttctgct gatagtaaag aaaatgtcgc
agcgctggcg aaggcagcga atagcgcgaa 2100tattaataat gttgcagtag
aaggaaaaat ctcaggtgcg aaatctgttg cgggattagt 2160agcgagcgca
acaaatacag tgatagaaaa cagctcgttt acagggaaac ttatcgcaaa
2220tcaccaggac agtaataaaa atgatactgg aggaatagta ggtaatataa
caggaaatag 2280ttcgagagtt aataaagtta gggtagatgc cttaatctct
actaatgcac gcaataataa 2340ccaaacagct ggagggatag taggtagatt
agaaaatggt gcattgatat ctaattcggt 2400tgctactgga gaaatacgaa
atggtcaagg atattctaga gtcggaggaa tagtaggatc 2460tacgtggcaa
aacggtcgag taaataatgt tgtgagtaac gtagatgttg gagatggtta
2520tgttatcacc ggtgatcaat acgcagcagc agatgtgaaa aatgcaagta
catcagttga 2580taatagaaaa gcagacagat tcgctacaaa attatcaaaa
gaccaaatag acgcgaaagt 2640tgctgattat ggaatcacag taactcttga
tgatactggg caagatttaa aacgtaatct 2700aagagaagtt gattatacaa
gactaaataa agcagaagct gaaagaaaag tagcttatag 2760caacatagaa
aaactgatgc cattctacaa taaagaccta gtagttcact atggtaacaa
2820agtagcgaca acagataaac tttacactac agaattgtta gatgttgtgc
cgatgaaaga 2880tgatgaagta gtaacggata ttaataataa gaaaaattca
ataaataaag ttatgttaca 2940tttcaaagat aatacagtag aatacctaga
tgtaacattc aaagaaaact tcataaacag 3000tcaagtaatc gaatacaatg
ttacaggaaa agaatatata ttcacaccag aagcatttgt 3060ttcagactat
acagcgataa cgaataacgt actaagcgac ttgcaaaatg taacacttaa 3120c
31211181040PRTStreptococcus pneumoniaeSITE(314)..(314)Xaa can be
any naturally occurring amino acid 118Phe Asn Pro Thr Val Gly Thr
Phe Leu Phe Thr Ala Gly Leu Ser Leu1 5 10 15Leu Val Leu Leu Val Ser
Lys Arg Glu Asn Gly Lys Lys Arg Leu Val 20 25 30His Phe Leu Leu Leu
Thr Ser Met Gly Val Gln Leu Leu Pro Ala Ser 35 40 45Ala Phe Gly Leu
Thr Ser Gln Ile Leu Ser Ala Tyr Asn Ser Gln Leu 50 55 60Ser Ile Gly
Val Gly Glu His Leu Pro Glu Pro Leu Lys Ile Glu Gly65 70 75 80Tyr
Gln Tyr Ile Gly Tyr Ile Lys Thr Lys Lys Gln Asp Asn Thr Glu 85 90
95Leu Ser Arg Thr Val Asp Gly Lys Tyr Ser Ala Gln Arg Asp Ser Gln
100 105 110Pro Asn Ser Thr Lys Thr Ser Asp Val Val His Ser Ala Asp
Leu Glu 115 120 125Trp Asn Gln Gly Gln Gly Lys Val Ser Leu Gln Gly
Glu Ala Ser Gly 130 135 140Asp Asp Gly Leu Ser Glu Lys Ser Ser Ile
Ala Ala Asp Asn Leu Ser145 150 155 160Ser Asn Asp Ser Phe Ala Ser
Gln Val Glu Gln Asn Pro Asp His Lys 165 170 175Gly Glu Ser Val Val
Arg Pro Thr Val Pro Glu Gln Gly Asn Pro Val 180 185 190Ser Ala Thr
Thr Val Gln Ser Ala Glu Glu Glu Val Leu Ala Thr Thr 195 200 205Asn
Asp Arg Pro Glu Tyr Lys Leu Pro Leu Glu Thr Lys Gly Thr Gln 210 215
220Glu Pro Gly His Glu Gly Glu Ala Ala Val Arg Glu Asp Leu Pro
Val225 230 235 240Tyr Thr Lys Pro Leu Glu Thr Lys Gly Thr Gln Gly
Pro Gly His Glu 245 250 255Gly Glu Ala Ala Val Arg Glu Glu Glu Pro
Ala Tyr Thr Glu Pro Leu 260 265 270Ala Thr Lys Gly Thr Gln Glu Pro
Gly His Glu Gly Lys Ala Thr Val 275 280 285Arg Glu Glu Thr Leu Glu
Tyr Thr Glu Pro Val Ala Thr Lys Gly Thr 290 295 300Gln Glu Pro Glu
His Glu Gly Glu Arg Xaa Val Glu Glu Glu Leu Pro305 310 315 320Ala
Leu Glu Val Thr Thr Arg Asn Arg Thr Glu Ile Gln Asn Ile Pro 325 330
335Tyr Thr Thr Glu Glu Ile Gln Asp Pro Thr Leu Leu Lys Asn Arg Arg
340 345 350Lys Ile Glu Arg Gln Gly Gln Ala Gly Thr Arg Thr Ile Gln
Tyr Glu 355 360 365Asp Tyr Ile Val Asn Gly Asn Val Val Glu Thr Lys
Glu Val Ser Arg 370 375 380Thr Glu Val Ala Pro Val Asn Glu Val Val
Lys Val Gly Thr Leu Val385 390 395 400Lys Val Lys Pro Thr Val Glu
Ile Thr Asn Leu Thr Lys Val Glu Asn 405 410 415Lys Lys Ser Ile Thr
Val Ser Tyr Asn Leu Ile Asp Thr Thr Ser Ala 420 425 430Tyr Val Ser
Ala Lys Thr Gln Val Phe His Gly Asp Lys Leu Val Lys 435 440 445Glu
Val Asp Ile Glu Asn Pro Ala Lys Glu Gln Val Ile Ser Gly Leu 450 455
460Asp Tyr Tyr Thr Pro Tyr Thr Val Lys Thr His Leu Thr Tyr Asn
Leu465 470 475 480Gly Glu Asn Asn Glu Glu Asn Thr Glu Thr Ser Thr
Gln Asp Phe Gln 485 490 495Leu Glu Tyr Lys Lys Ile Glu Ile Lys Asp
Ile Asp Ser Val Glu Leu 500 505 510Tyr Gly Lys Glu Asn Asp Arg Tyr
Arg Arg Tyr Leu Ser Leu Ser Glu 515 520 525Ala Pro Thr Asp Thr Ala
Lys Tyr Phe Val Lys Val Lys Ser Asp Arg 530 535 540Phe Lys Glu Met
Tyr Leu Pro Val Lys Ser Ile Thr Glu Asn Thr Asp545 550 555 560Gly
Thr Tyr Lys Val Thr Val Ala Val Asp Gln Leu Val Glu Glu Gly 565 570
575Thr Asp Gly Tyr Lys Asp Asp Tyr Thr Phe Thr Val Ala Lys Ser Lys
580 585 590Ala Glu Gln Pro Gly Val Tyr Thr Ser Phe Lys Gln Leu Val
Thr Ala 595 600 605Met Gln Ser Asn Leu Ser Gly Val Tyr Thr Leu Ala
Ser Asp Met Thr 610 615 620Ala Asp Glu Val Ser Leu Gly Asp
Lys Gln Thr Ser Tyr Leu Thr Gly625 630 635 640Ala Phe Thr Gly Ser
Leu Ile Gly Ser Asp Gly Thr Lys Ser Tyr Ala 645 650 655Ile Tyr Asp
Leu Lys Lys Pro Leu Phe Asp Thr Leu Asn Gly Ala Thr 660 665 670Val
Arg Asp Leu Asp Ile Lys Thr Val Ser Ala Asp Ser Lys Glu Asn 675 680
685Val Ala Ala Leu Ala Lys Ala Ala Asn Ser Ala Asn Ile Asn Asn Val
690 695 700Ala Val Glu Gly Lys Ile Ser Gly Ala Lys Ser Val Ala Gly
Leu Val705 710 715 720Ala Ser Ala Thr Asn Thr Val Ile Glu Asn Ser
Ser Phe Thr Gly Lys 725 730 735Leu Ile Ala Asn His Gln Asp Ser Asn
Lys Asn Asp Thr Gly Gly Ile 740 745 750Val Gly Asn Ile Thr Gly Asn
Ser Ser Arg Val Asn Lys Val Arg Val 755 760 765Asp Ala Leu Ile Ser
Thr Asn Ala Arg Asn Asn Asn Gln Thr Ala Gly 770 775 780Gly Ile Val
Gly Arg Leu Glu Asn Gly Ala Leu Ile Ser Asn Ser Val785 790 795
800Ala Thr Gly Glu Ile Arg Asn Gly Gln Gly Tyr Ser Arg Val Gly Gly
805 810 815Ile Val Gly Ser Thr Trp Gln Asn Gly Arg Val Asn Asn Val
Val Ser 820 825 830Asn Val Asp Val Gly Asp Gly Tyr Val Ile Thr Gly
Asp Gln Tyr Ala 835 840 845Ala Ala Asp Val Lys Asn Ala Ser Thr Ser
Val Asp Asn Arg Lys Ala 850 855 860Asp Arg Phe Ala Thr Lys Leu Ser
Lys Asp Gln Ile Asp Ala Lys Val865 870 875 880Ala Asp Tyr Gly Ile
Thr Val Thr Leu Asp Asp Thr Gly Gln Asp Leu 885 890 895Lys Arg Asn
Leu Arg Glu Val Asp Tyr Thr Arg Leu Asn Lys Ala Glu 900 905 910Ala
Glu Arg Lys Val Ala Tyr Ser Asn Ile Glu Lys Leu Met Pro Phe 915 920
925Tyr Asn Lys Asp Leu Val Val His Tyr Gly Asn Lys Val Ala Thr Thr
930 935 940Asp Lys Leu Tyr Thr Thr Glu Leu Leu Asp Val Val Pro Met
Lys Asp945 950 955 960Asp Glu Val Val Thr Asp Ile Asn Asn Lys Lys
Asn Ser Ile Asn Lys 965 970 975Val Met Leu His Phe Lys Asp Asn Thr
Val Glu Tyr Leu Asp Val Thr 980 985 990Phe Lys Glu Asn Phe Ile Asn
Ser Gln Val Ile Glu Tyr Asn Val Thr 995 1000 1005Gly Lys Glu Tyr
Ile Phe Thr Pro Glu Ala Phe Val Ser Asp Tyr 1010 1015 1020Thr Ala
Ile Thr Asn Asn Val Leu Ser Asp Leu Gln Asn Val Thr 1025 1030
1035Leu Asn 10401191567DNAStreptococcus pneumoniae 119ttttaaccca
actgttggta ctttcctttt tactgcagga ttgagcttgt tagttttatt 60ggtttctaaa
agggaaaatg gaaagaaacg acttgttcat tttctgctgt tgactagcat
120gggagttcaa ttgttgccgg ccagtgcttt tgggttgacc agccagattt
tatctgccta 180taatagtcag ctttctatcg gagtcgggga acatttacca
gagcctctga aaatcgaagg 240ttatcaatat attggttata tcaaaactaa
gaaacaggat aatacagagc tttcaaggac 300agttgatggg aaatactctg
ctcaaagaga tagtcaacca aactctacaa aaacatcaga 360tgtagttcat
tcagctgatt tagaatggaa ccaaggacag gggaaggtta gtttacaagg
420tgaagcatca ggggatgatg gactttcaga aaaatcttct atagcagcag
acaatctatc 480ttctaatgat tcattcgcaa gtcaagttga gcagaatccg
gatcacaaag gagaatctgt 540agttcgacca acagtgccag aacaaggaaa
tcctgtgtct gctacaacgg tgcagagtgc 600ggaagaggaa gtattggcga
cgacaaatga tcgaccagag tataaacttc cattggaaac 660caaaggcacg
caagaacccg gtcatgaggg tgaagccgca gtccgtgaag acttaccagt
720ctacactaag ccactagaaa ccaaaggtac acaaggaccc ggacatgaag
gtgaagctgc 780agttcgcgag gaagaaccag cttacacaga accgttagca
acgaaaggca cgcaagagcc 840aggtcatgag ggcaaagcta cagtccgcga
agagactcta gagtacacgg aaccggtagc 900gacaaaaggc acacaagaac
ccgaacatga gggcgaacgg scagtagaag aagaacttcc 960ggctttagag
gtcactacac gaaatagaac ggaaatccag aatattcctt atacaacaga
1020agaaattcag gatccaacac ttctgaaaaa tcgtcgtaag attgaacgac
aagggcaagc 1080agggacacgt acaattcaat atgaagacta catcgtaaat
ggtaatgtcg tagaaactaa 1140agaagtgtca cgaactgaag tagctccggt
caacgaagtc gttaaagtag gaacacttgt 1200gaaagttaaa cctacagtag
aaattacaaa cttaacaaaa gttgagaaca aaaaatctat 1260aactgtaagt
tataacttaa tagacactac ctcagcatat gtttctgcaa aaacgcaagt
1320tttccatgga gacaagctag ttaaagaggt ggatatagaa aatcctgcca
aagagcaagt 1380aatatcaggt ttagattact acacaccgta tacagttaaa
acacacctaa cttataattt 1440gggtgaaaat aatgaggaaa atactgaaac
atcaactcaa gatttccaat tagagtataa 1500gaaaatagag attaaagata
ttgattcagt agaattatac ggtaaagaaa atgatcgtta 1560tcgtaga
1567120522PRTStreptococcus pneumoniaeSITE(314)..(314)Xaa can be any
naturally occurring amino acid 120Phe Asn Pro Thr Val Gly Thr Phe
Leu Phe Thr Ala Gly Leu Ser Leu1 5 10 15Leu Val Leu Leu Val Ser Lys
Arg Glu Asn Gly Lys Lys Arg Leu Val 20 25 30His Phe Leu Leu Leu Thr
Ser Met Gly Val Gln Leu Leu Pro Ala Ser 35 40 45Ala Phe Gly Leu Thr
Ser Gln Ile Leu Ser Ala Tyr Asn Ser Gln Leu 50 55 60Ser Ile Gly Val
Gly Glu His Leu Pro Glu Pro Leu Lys Ile Glu Gly65 70 75 80Tyr Gln
Tyr Ile Gly Tyr Ile Lys Thr Lys Lys Gln Asp Asn Thr Glu 85 90 95Leu
Ser Arg Thr Val Asp Gly Lys Tyr Ser Ala Gln Arg Asp Ser Gln 100 105
110Pro Asn Ser Thr Lys Thr Ser Asp Val Val His Ser Ala Asp Leu Glu
115 120 125Trp Asn Gln Gly Gln Gly Lys Val Ser Leu Gln Gly Glu Ala
Ser Gly 130 135 140Asp Asp Gly Leu Ser Glu Lys Ser Ser Ile Ala Ala
Asp Asn Leu Ser145 150 155 160Ser Asn Asp Ser Phe Ala Ser Gln Val
Glu Gln Asn Pro Asp His Lys 165 170 175Gly Glu Ser Val Val Arg Pro
Thr Val Pro Glu Gln Gly Asn Pro Val 180 185 190Ser Ala Thr Thr Val
Gln Ser Ala Glu Glu Glu Val Leu Ala Thr Thr 195 200 205Asn Asp Arg
Pro Glu Tyr Lys Leu Pro Leu Glu Thr Lys Gly Thr Gln 210 215 220Glu
Pro Gly His Glu Gly Glu Ala Ala Val Arg Glu Asp Leu Pro Val225 230
235 240Tyr Thr Lys Pro Leu Glu Thr Lys Gly Thr Gln Gly Pro Gly His
Glu 245 250 255Gly Glu Ala Ala Val Arg Glu Glu Glu Pro Ala Tyr Thr
Glu Pro Leu 260 265 270Ala Thr Lys Gly Thr Gln Glu Pro Gly His Glu
Gly Lys Ala Thr Val 275 280 285Arg Glu Glu Thr Leu Glu Tyr Thr Glu
Pro Val Ala Thr Lys Gly Thr 290 295 300Gln Glu Pro Glu His Glu Gly
Glu Arg Xaa Val Glu Glu Glu Leu Pro305 310 315 320Ala Leu Glu Val
Thr Thr Arg Asn Arg Thr Glu Ile Gln Asn Ile Pro 325 330 335Tyr Thr
Thr Glu Glu Ile Gln Asp Pro Thr Leu Leu Lys Asn Arg Arg 340 345
350Lys Ile Glu Arg Gln Gly Gln Ala Gly Thr Arg Thr Ile Gln Tyr Glu
355 360 365Asp Tyr Ile Val Asn Gly Asn Val Val Glu Thr Lys Glu Val
Ser Arg 370 375 380Thr Glu Val Ala Pro Val Asn Glu Val Val Lys Val
Gly Thr Leu Val385 390 395 400Lys Val Lys Pro Thr Val Glu Ile Thr
Asn Leu Thr Lys Val Glu Asn 405 410 415Lys Lys Ser Ile Thr Val Ser
Tyr Asn Leu Ile Asp Thr Thr Ser Ala 420 425 430Tyr Val Ser Ala Lys
Thr Gln Val Phe His Gly Asp Lys Leu Val Lys 435 440 445Glu Val Asp
Ile Glu Asn Pro Ala Lys Glu Gln Val Ile Ser Gly Leu 450 455 460Asp
Tyr Tyr Thr Pro Tyr Thr Val Lys Thr His Leu Thr Tyr Asn Leu465 470
475 480Gly Glu Asn Asn Glu Glu Asn Thr Glu Thr Ser Thr Gln Asp Phe
Gln 485 490 495Leu Glu Tyr Lys Lys Ile Glu Ile Lys Asp Ile Asp Ser
Val Glu Leu 500 505 510Tyr Gly Lys Glu Asn Asp Arg Tyr Arg Arg 515
5201211561DNAStreptococcus pneumoniae 121tcgtagatat ttaagtctaa
gtgaagcgcc gactgatacg gctaaatact ttgtaaaagt 60gaaatcagat cgcttcaaag
aaatgtacct acctgtaaaa tctattacag aaaatacgga 120tggaacgtat
aaagtgacgg tagccgttga tcaacttgtc gaagaaggta cagacggtta
180caaagatgat tacacattta ctgtagctaa atctaaagca gagcaaccag
gagtttacac 240atcctttaaa cagctggtaa cagccatgca aagcaatctg
tctggtgtct atacattggc 300ttcagatatg accgcagatg aggtgagctt
aggcgataag cagacaagtt atctcacagg 360tgcatttaca gggagcttga
tcggttctga tggaacaaaa tcgtatgcca tttatgattt 420gaagaaacca
ttatttgata cattaaatgg tgctacagtt agagatttgg atattaaaac
480tgtttctgct gatagtaaag aaaatgtcgc agcgctggcg aaggcagcga
atagcgcgaa 540tattaataat gttgcagtag aaggaaaaat ctcaggtgcg
aaatctgttg cgggattagt 600agcgagcgca acaaatacag tgatagaaaa
cagctcgttt acagggaaac ttatcgcaaa 660tcaccaggac agtaataaaa
atgatactgg aggaatagta ggtaatataa caggaaatag 720ttcgagagtt
aataaagtta gggtagatgc cttaatctct actaatgcac gcaataataa
780ccaaacagct ggagggatag taggtagatt agaaaatggt gcattgatat
ctaattcggt 840tgctactgga gaaatacgaa atggtcaagg atattctaga
gtcggaggaa tagtaggatc 900tacgtggcaa aacggtcgag taaataatgt
tgtgagtaac gtagatgttg gagatggtta 960tgttatcacc ggtgatcaat
acgcagcagc agatgtgaaa aatgcaagta catcagttga 1020taatagaaaa
gcagacagat tcgctacaaa attatcaaaa gaccaaatag acgcgaaagt
1080tgctgattat ggaatcacag taactcttga tgatactggg caagatttaa
aacgtaatct 1140aagagaagtt gattatacaa gactaaataa agcagaagct
gaaagaaaag tagcttatag 1200caacatagaa aaactgatgc cattctacaa
taaagaccta gtagttcact atggtaacaa 1260agtagcgaca acagataaac
tttacactac agaattgtta gatgttgtgc cgatgaaaga 1320tgatgaagta
gtaacggata ttaataataa gaaaaattca ataaataaag ttatgttaca
1380tttcaaagat aatacagtag aatacctaga tgtaacattc aaagaaaact
tcataaacag 1440tcaagtaatc gaatacaatg ttacaggaaa agaatatata
ttcacaccag aagcatttgt 1500ttcagactat acagcgataa cgaataacgt
actaagcgac ttgcaaaatg taacacttaa 1560c 1561122520PRTStreptococcus
pneumoniae 122Arg Arg Tyr Leu Ser Leu Ser Glu Ala Pro Thr Asp Thr
Ala Lys Tyr1 5 10 15Phe Val Lys Val Lys Ser Asp Arg Phe Lys Glu Met
Tyr Leu Pro Val 20 25 30Lys Ser Ile Thr Glu Asn Thr Asp Gly Thr Tyr
Lys Val Thr Val Ala 35 40 45Val Asp Gln Leu Val Glu Glu Gly Thr Asp
Gly Tyr Lys Asp Asp Tyr 50 55 60Thr Phe Thr Val Ala Lys Ser Lys Ala
Glu Gln Pro Gly Val Tyr Thr65 70 75 80Ser Phe Lys Gln Leu Val Thr
Ala Met Gln Ser Asn Leu Ser Gly Val 85 90 95Tyr Thr Leu Ala Ser Asp
Met Thr Ala Asp Glu Val Ser Leu Gly Asp 100 105 110Lys Gln Thr Ser
Tyr Leu Thr Gly Ala Phe Thr Gly Ser Leu Ile Gly 115 120 125Ser Asp
Gly Thr Lys Ser Tyr Ala Ile Tyr Asp Leu Lys Lys Pro Leu 130 135
140Phe Asp Thr Leu Asn Gly Ala Thr Val Arg Asp Leu Asp Ile Lys
Thr145 150 155 160Val Ser Ala Asp Ser Lys Glu Asn Val Ala Ala Leu
Ala Lys Ala Ala 165 170 175Asn Ser Ala Asn Ile Asn Asn Val Ala Val
Glu Gly Lys Ile Ser Gly 180 185 190Ala Lys Ser Val Ala Gly Leu Val
Ala Ser Ala Thr Asn Thr Val Ile 195 200 205Glu Asn Ser Ser Phe Thr
Gly Lys Leu Ile Ala Asn His Gln Asp Ser 210 215 220Asn Lys Asn Asp
Thr Gly Gly Ile Val Gly Asn Ile Thr Gly Asn Ser225 230 235 240Ser
Arg Val Asn Lys Val Arg Val Asp Ala Leu Ile Ser Thr Asn Ala 245 250
255Arg Asn Asn Asn Gln Thr Ala Gly Gly Ile Val Gly Arg Leu Glu Asn
260 265 270Gly Ala Leu Ile Ser Asn Ser Val Ala Thr Gly Glu Ile Arg
Asn Gly 275 280 285Gln Gly Tyr Ser Arg Val Gly Gly Ile Val Gly Ser
Thr Trp Gln Asn 290 295 300Gly Arg Val Asn Asn Val Val Ser Asn Val
Asp Val Gly Asp Gly Tyr305 310 315 320Val Ile Thr Gly Asp Gln Tyr
Ala Ala Ala Asp Val Lys Asn Ala Ser 325 330 335Thr Ser Val Asp Asn
Arg Lys Ala Asp Arg Phe Ala Thr Lys Leu Ser 340 345 350Lys Asp Gln
Ile Asp Ala Lys Val Ala Asp Tyr Gly Ile Thr Val Thr 355 360 365Leu
Asp Asp Thr Gly Gln Asp Leu Lys Arg Asn Leu Arg Glu Val Asp 370 375
380Tyr Thr Arg Leu Asn Lys Ala Glu Ala Glu Arg Lys Val Ala Tyr
Ser385 390 395 400Asn Ile Glu Lys Leu Met Pro Phe Tyr Asn Lys Asp
Leu Val Val His 405 410 415Tyr Gly Asn Lys Val Ala Thr Thr Asp Lys
Leu Tyr Thr Thr Glu Leu 420 425 430Leu Asp Val Val Pro Met Lys Asp
Asp Glu Val Val Thr Asp Ile Asn 435 440 445Asn Lys Lys Asn Ser Ile
Asn Lys Val Met Leu His Phe Lys Asp Asn 450 455 460Thr Val Glu Tyr
Leu Asp Val Thr Phe Lys Glu Asn Phe Ile Asn Ser465 470 475 480Gln
Val Ile Glu Tyr Asn Val Thr Gly Lys Glu Tyr Ile Phe Thr Pro 485 490
495Glu Ala Phe Val Ser Asp Tyr Thr Ala Ile Thr Asn Asn Val Leu Ser
500 505 510Asp Leu Gln Asn Val Thr Leu Asn 515
520123850DNAStreptococcus pneumoniae 123ctttggtttt gaaggaagta
agcgtggaca atttgctgta gaaggaatca atcaacttcg 60tgagcatgta gacactctat
tgattatctc aaacaacaat ttgcttgaaa ttgttgataa 120gaaaacaccg
cttttggagg ctcttagcga agcggataac gttcttcgtc aaggtgttca
180agggattacc gatttgatta ccaatccagg attgattaac cttgactttg
ccgatgtgaa 240aacggtaatg gcaaacaaag ggaatgctct tatgggtatt
ggtatcggta gtggagaaga 300acgtgtggta gaagcggcac gtaaggcaat
ctattcacca cttcttgaaa caactattga 360cggtgctgag gatgttatcg
tcaacgttac tggtggtctt gacttaacct tgattgaggc 420agaagaggct
tcacaaattg tgaaccaggc agcaggtcaa ggagtgaaca tctggctcgg
480tacttcaatt gatgaaagta tgcgtgatga aattcgtgta acagttgttg
caacgggtgt 540tcgtcaagac cgcgtagaaa aggttgtggc tccacaagct
agatctgcta ctaactaccg 600tgagacagtg aaaccagctc attcacatgg
ctttgatcgt cattttgata tggcagaaac 660agttgaattg ccaaaacaaa
atccacgtcg tttggaacca actcaggcat ctgcttttgg 720tgattgggat
cttcgccgtg aatcgattgt tcgtacaaca gattcagtcg tttctccagt
780cgagcgcttt gaagccccaa tttcacaaga tgaagatgaa ttggatacac
ctccattttt 840caaaaatcgt 850124283PRTStreptococcus pneumoniae
124Phe Gly Phe Glu Gly Ser Lys Arg Gly Gln Phe Ala Val Glu Gly Ile1
5 10 15Asn Gln Leu Arg Glu His Val Asp Thr Leu Leu Ile Ile Ser Asn
Asn 20 25 30Asn Leu Leu Glu Ile Val Asp Lys Lys Thr Pro Leu Leu Glu
Ala Leu 35 40 45Ser Glu Ala Asp Asn Val Leu Arg Gln Gly Val Gln Gly
Ile Thr Asp 50 55 60Leu Ile Thr Asn Pro Gly Leu Ile Asn Leu Asp Phe
Ala Asp Val Lys65 70 75 80Thr Val Met Ala Asn Lys Gly Asn Ala Leu
Met Gly Ile Gly Ile Gly 85 90 95Ser Gly Glu Glu Arg Val Val Glu Ala
Ala Arg Lys Ala Ile Tyr Ser 100 105 110Pro Leu Leu Glu Thr Thr Ile
Asp Gly Ala Glu Asp Val Ile Val Asn 115 120 125Val Thr Gly Gly Leu
Asp Leu Thr Leu Ile Glu Ala Glu Glu Ala Ser 130 135 140Gln Ile Val
Asn Gln Ala Ala Gly Gln Gly Val Asn Ile Trp Leu Gly145 150 155
160Thr Ser Ile Asp Glu Ser Met Arg Asp Glu Ile Arg Val Thr Val Val
165 170 175Ala Thr Gly Val Arg Gln Asp Arg Val Glu Lys Val Val Ala
Pro Gln 180 185 190Ala Arg Ser Ala Thr Asn Tyr Arg Glu Thr Val Lys
Pro Ala His Ser 195 200 205His Gly Phe Asp Arg His Phe Asp Met Ala
Glu Thr Val Glu Leu Pro 210 215 220Lys Gln Asn Pro Arg Arg Leu Glu
Pro Thr Gln Ala Ser Ala Phe Gly225 230 235 240Asp Trp Asp Leu Arg
Arg Glu Ser Ile Val Arg Thr Thr Asp Ser Val 245 250 255Val Ser Pro
Val Glu Arg Phe Glu Ala Pro Ile Ser Gln Asp Glu Asp 260 265 270Glu
Leu Asp Thr Pro Pro Phe Phe Lys Asn Arg 275
2801251051DNAStreptococcus pneumoniae 125ctactacctc tcgagagaaa
gtgacctaga ggtgaccgtt tttgaccatg agcaaggtca
60agccaccaag gccgcagcag gaattatcag tccttggttt tccaaacgcc gtaataaagc
120ctggtacaag atggcgcgct tgggggctga tttttatgtg gatttattag
ctgatttaga 180gaaatcagga caagaaatcg acttttacca gcgttcggga
gtctttctct tgaaaaagga 240tgaatccaat ttggaagaac tttatcaact
ggccctccag cgcagagaag aatctccctt 300gatagggcaa ttagccattc
tgaaccaagc ctcagctaat gaattattcc ctggtttgca 360gggatttgac
cgcctgctct atgcttctgg tggagcgaga gtagatggcc aacttttagt
420gactcgtttg ctggaagtca gtcatgtcaa gctggtcaaa gaaaaagtga
ctctgacacc 480gttagcatca ggctaccaga ttggtgaaga ggagtttgag
caggttattt tggcgacggg 540agcttggttg ggggacatgt tagagccttt
aggttatgaa gtggatgtcc gtcctcaaaa 600aggacaacta cgagattatc
agcttgccca agacatggaa gattaccctg ttgtcatgcc 660agaaggggag
tgggatttga ttccctttgc aggtgggaaa ttatccttag gcgctaccca
720cgaaaatgac atgggatttg atttgacggt agatgaaacc ttgctccaac
aaatggagga 780ggccaccttg actcactatc tgattttggc tgaagctact
tcaaaatctg agcgtgttgg 840aatccgtgcc tacaccagtg atttctctcc
tttctttggg caggtgcctg acttaactgg 900tgtctatgca gccagtggac
taggttcatc aggcctcaca actggtccta tcattggtta 960ccatctagcc
caactgatcc aagacaagga gttgaccttg gaccctctaa attacccaat
1020tgaaaactat gtcaaacgag taaaaagcga a 1051126350PRTStreptococcus
pneumoniae 126Tyr Tyr Leu Ser Arg Glu Ser Asp Leu Glu Val Thr Val
Phe Asp His1 5 10 15Glu Gln Gly Gln Ala Thr Lys Ala Ala Ala Gly Ile
Ile Ser Pro Trp 20 25 30Phe Ser Lys Arg Arg Asn Lys Ala Trp Tyr Lys
Met Ala Arg Leu Gly 35 40 45Ala Asp Phe Tyr Val Asp Leu Leu Ala Asp
Leu Glu Lys Ser Gly Gln 50 55 60Glu Ile Asp Phe Tyr Gln Arg Ser Gly
Val Phe Leu Leu Lys Lys Asp65 70 75 80Glu Ser Asn Leu Glu Glu Leu
Tyr Gln Leu Ala Leu Gln Arg Arg Glu 85 90 95Glu Ser Pro Leu Ile Gly
Gln Leu Ala Ile Leu Asn Gln Ala Ser Ala 100 105 110Asn Glu Leu Phe
Pro Gly Leu Gln Gly Phe Asp Arg Leu Leu Tyr Ala 115 120 125Ser Gly
Gly Ala Arg Val Asp Gly Gln Leu Leu Val Thr Arg Leu Leu 130 135
140Glu Val Ser His Val Lys Leu Val Lys Glu Lys Val Thr Leu Thr
Pro145 150 155 160Leu Ala Ser Gly Tyr Gln Ile Gly Glu Glu Glu Phe
Glu Gln Val Ile 165 170 175Leu Ala Thr Gly Ala Trp Leu Gly Asp Met
Leu Glu Pro Leu Gly Tyr 180 185 190Glu Val Asp Val Arg Pro Gln Lys
Gly Gln Leu Arg Asp Tyr Gln Leu 195 200 205Ala Gln Asp Met Glu Asp
Tyr Pro Val Val Met Pro Glu Gly Glu Trp 210 215 220Asp Leu Ile Pro
Phe Ala Gly Gly Lys Leu Ser Leu Gly Ala Thr His225 230 235 240Glu
Asn Asp Met Gly Phe Asp Leu Thr Val Asp Glu Thr Leu Leu Gln 245 250
255Gln Met Glu Glu Ala Thr Leu Thr His Tyr Leu Ile Leu Ala Glu Ala
260 265 270Thr Ser Lys Ser Glu Arg Val Gly Ile Arg Ala Tyr Thr Ser
Asp Phe 275 280 285Ser Pro Phe Phe Gly Gln Val Pro Asp Leu Thr Gly
Val Tyr Ala Ala 290 295 300Ser Gly Leu Gly Ser Ser Gly Leu Thr Thr
Gly Pro Ile Ile Gly Tyr305 310 315 320His Leu Ala Gln Leu Ile Gln
Asp Lys Glu Leu Thr Leu Asp Pro Leu 325 330 335Asn Tyr Pro Ile Glu
Asn Tyr Val Lys Arg Val Lys Ser Glu 340 345
350127352DNAStreptococcus pneumoniae 127taaggtcaaa agtcagaccg
ctaagaaagt gctagaaaag attggagctg actcggttat 60ctcgccagag tatgaaatgg
ggcagtctct agcacagacc attcttttcc ataatagtgt 120tgatgtcttt
cagttggata aaaatgtgtc tatcgtggag atgaaaattc ctcagtcttg
180ggcaggtcaa agtctgagta aattagacct ccgtggcaaa tacaatctga
atattttggg 240tttccgagag caggaaaatt ccccattgga tgttgaattt
ggaccagatg acctcttgaa 300agcagatacc tatattttgg cagtcatcaa
caaccagtat ttggataccc ta 352128117PRTStreptococcus pneumoniae
128Lys Val Lys Ser Gln Thr Ala Lys Lys Val Leu Glu Lys Ile Gly Ala1
5 10 15Asp Ser Val Ile Ser Pro Glu Tyr Glu Met Gly Gln Ser Leu Ala
Gln 20 25 30Thr Ile Leu Phe His Asn Ser Val Asp Val Phe Gln Leu Asp
Lys Asn 35 40 45Val Ser Ile Val Glu Met Lys Ile Pro Gln Ser Trp Ala
Gly Gln Ser 50 55 60Leu Ser Lys Leu Asp Leu Arg Gly Lys Tyr Asn Leu
Asn Ile Leu Gly65 70 75 80Phe Arg Glu Gln Glu Asn Ser Pro Leu Asp
Val Glu Phe Gly Pro Asp 85 90 95Asp Leu Leu Lys Ala Asp Thr Tyr Ile
Leu Ala Val Ile Asn Asn Gln 100 105 110Tyr Leu Asp Thr Leu
115129247DNAStreptococcus pneumoniae 129tgacgggtct caggatcaga
ctcaggaaat cgctgagtgt ttagctagca agtatcctaa 60tatcgttaga gccatctatc
aggaaaataa atgccatggc ggtgcggtca atcgtggctt 120ggtagaggct
tctgggcgct attttaaagt agttgacagt gatgactggg tggatcctcg
180tgcctacttg aaaattcttg aaacttgcag gaacttgaga gcaaaggtca
agaggtggat 240gtctttg 24713082PRTStreptococcus pneumoniae 130Asp
Gly Ser Gln Asp Gln Thr Gln Glu Ile Ala Glu Cys Leu Ala Ser1 5 10
15Lys Tyr Pro Asn Ile Val Arg Ala Ile Tyr Gln Glu Asn Lys Cys His
20 25 30Gly Gly Ala Val Asn Arg Gly Leu Val Glu Ala Ser Gly Arg Tyr
Phe 35 40 45Lys Val Val Asp Ser Asp Asp Trp Val Asp Pro Arg Ala Tyr
Leu Lys 50 55 60Ile Leu Glu Thr Cys Arg Asn Leu Arg Ala Lys Val Lys
Arg Trp Met65 70 75 80Ser Leu1311744DNAStreptococcus pneumoniae
131tagaggcttt gccaaatggt gggaagggca cgagcgtcga aaagaggaac
gctttgtcaa 60acaagaagaa aaagctcgcc aaaaggctga gaaagaggct agattagaac
aagaagagac 120tgaaaaagcc ttactcgatt tgcctcctgt tgatatggaa
acgggtgaaa ttctgacaga 180ggaagctgtt caaaatcttc cacctattcc
agaagaaaag tgggtggaac cagaaatcat 240cctgcctcaa gctgaactta
aattccctga acaggaagat gactcagatg acgaagatgt 300tcaggtcgat
ttttcagcca aagaagccct tgaatacaaa cttccaagct tacaactctt
360tgcaccagat aaaccaaaag atcagtctaa agagaagaaa attgtcagag
aaaatatcaa 420aatcttagaa gcaacctttg ctagctttgg tattaaggta
acagttgaac gggccgaaat 480tgggccatca gtgaccaagt atgaagtcaa
gccggctgtt ggtgtaaggg tcaaccgcat 540ttccaatcta tcagatgacc
tcgctctagc cttggctgcc aaagatgtcc ggattgaagc 600accaatccct
gggaaatccc taatcggaat tgaagtgccc aactccgata ttgccactgt
660atctttccga gaactatggg aacaatcgca aacgaaagca gaaaatttct
tggaaattcc 720tttagggaag gctgttaatg gaaccgcaag agcttttgac
ctttctaaaa tgccccactt 780gctagttgca ggttcaacgg gttcagggaa
gtcagtagca gttaacggca ttattgctag 840cattctcatg aaggcgagac
cagatcaagt taaatttatg atggtcgatc ccaagatggt 900tgagttatct
gtttacaatg atattcccca cctcttgatt ccagtcgtga ccaatccacg
960caaagccagc aaggctctgc aaaaggttgt ggatgaaatg gaaaaccgtt
atgaactctt 1020tgccaaggtg ggagttcgga atattgcagg ttttaatgcc
aaggtagaag agttcaattc 1080ccagtctgag tacaagcaaa ttccgctacc
attcattgtc gtgattgtgg atgagttggc 1140tgacctcatg atggtggcca
gcaaggaagt ggaagatgct atcatccgtc ttgggcagaa 1200ggcgcgtgct
gcaggtatcc acatgattct tgcaactcag cgtccatctg ttgatgtcat
1260ctctggtttg attaaggcca atgttccatc tcgtgtagca tttgcggttt
catcaggaac 1320agactcccgt acgattttgg atgaaaatgg agcagaaaaa
cttcttggtc gaggagacat 1380gctctttaaa ccgattgatg aaaatcatcc
agttcgtctc caaggctcct ttatctcgga 1440tgacgatgtt gagcgcattg
tgaacttcat caagactcag gcagatgcag actacgatga 1500gagttttgat
ccaggtgagg tttctgaaaa tgaaggagaa ttttcggatg gagatgctgg
1560tggtgatccg ctttttgaag aagctaagtc tttggttatc gaaacacaga
aagccagtgc 1620gtctatgatt cagcgtcgtt tatcagttgg atttaaccgt
gcgacccgtc tcatggaaga 1680actggagata gcaggtgtca tcggtccagc
tgaaggtacc aaacctcgaa aagtgttaca 1740acaa
1744132581PRTStreptococcus pneumoniae 132Arg Gly Phe Ala Lys Trp
Trp Glu Gly His Glu Arg Arg Lys Glu Glu1 5 10 15Arg Phe Val Lys Gln
Glu Glu Lys Ala Arg Gln Lys Ala Glu Lys Glu 20 25 30Ala Arg Leu Glu
Gln Glu Glu Thr Glu Lys Ala Leu Leu Asp Leu Pro 35 40 45Pro Val Asp
Met Glu Thr Gly Glu Ile Leu Thr Glu Glu Ala Val Gln 50 55 60Asn Leu
Pro Pro Ile Pro Glu Glu Lys Trp Val Glu Pro Glu Ile Ile65 70 75
80Leu Pro Gln Ala Glu Leu Lys Phe Pro Glu Gln Glu Asp Asp Ser Asp
85 90 95Asp Glu Asp Val Gln Val Asp Phe Ser Ala Lys Glu Ala Leu Glu
Tyr 100 105 110Lys Leu Pro Ser Leu Gln Leu Phe Ala Pro Asp Lys Pro
Lys Asp Gln 115 120 125Ser Lys Glu Lys Lys Ile Val Arg Glu Asn Ile
Lys Ile Leu Glu Ala 130 135 140Thr Phe Ala Ser Phe Gly Ile Lys Val
Thr Val Glu Arg Ala Glu Ile145 150 155 160Gly Pro Ser Val Thr Lys
Tyr Glu Val Lys Pro Ala Val Gly Val Arg 165 170 175Val Asn Arg Ile
Ser Asn Leu Ser Asp Asp Leu Ala Leu Ala Leu Ala 180 185 190Ala Lys
Asp Val Arg Ile Glu Ala Pro Ile Pro Gly Lys Ser Leu Ile 195 200
205Gly Ile Glu Val Pro Asn Ser Asp Ile Ala Thr Val Ser Phe Arg Glu
210 215 220Leu Trp Glu Gln Ser Gln Thr Lys Ala Glu Asn Phe Leu Glu
Ile Pro225 230 235 240Leu Gly Lys Ala Val Asn Gly Thr Ala Arg Ala
Phe Asp Leu Ser Lys 245 250 255Met Pro His Leu Leu Val Ala Gly Ser
Thr Gly Ser Gly Lys Ser Val 260 265 270Ala Val Asn Gly Ile Ile Ala
Ser Ile Leu Met Lys Ala Arg Pro Asp 275 280 285Gln Val Lys Phe Met
Met Val Asp Pro Lys Met Val Glu Leu Ser Val 290 295 300Tyr Asn Asp
Ile Pro His Leu Leu Ile Pro Val Val Thr Asn Pro Arg305 310 315
320Lys Ala Ser Lys Ala Leu Gln Lys Val Val Asp Glu Met Glu Asn Arg
325 330 335Tyr Glu Leu Phe Ala Lys Val Gly Val Arg Asn Ile Ala Gly
Phe Asn 340 345 350Ala Lys Val Glu Glu Phe Asn Ser Gln Ser Glu Tyr
Lys Gln Ile Pro 355 360 365Leu Pro Phe Ile Val Val Ile Val Asp Glu
Leu Ala Asp Leu Met Met 370 375 380Val Ala Ser Lys Glu Val Glu Asp
Ala Ile Ile Arg Leu Gly Gln Lys385 390 395 400Ala Arg Ala Ala Gly
Ile His Met Ile Leu Ala Thr Gln Arg Pro Ser 405 410 415Val Asp Val
Ile Ser Gly Leu Ile Lys Ala Asn Val Pro Ser Arg Val 420 425 430Ala
Phe Ala Val Ser Ser Gly Thr Asp Ser Arg Thr Ile Leu Asp Glu 435 440
445Asn Gly Ala Glu Lys Leu Leu Gly Arg Gly Asp Met Leu Phe Lys Pro
450 455 460Ile Asp Glu Asn His Pro Val Arg Leu Gln Gly Ser Phe Ile
Ser Asp465 470 475 480Asp Asp Val Glu Arg Ile Val Asn Phe Ile Lys
Thr Gln Ala Asp Ala 485 490 495Asp Tyr Asp Glu Ser Phe Asp Pro Gly
Glu Val Ser Glu Asn Glu Gly 500 505 510Glu Phe Ser Asp Gly Asp Ala
Gly Gly Asp Pro Leu Phe Glu Glu Ala 515 520 525Lys Ser Leu Val Ile
Glu Thr Gln Lys Ala Ser Ala Ser Met Ile Gln 530 535 540Arg Arg Leu
Ser Val Gly Phe Asn Arg Ala Thr Arg Leu Met Glu Glu545 550 555
560Leu Glu Ile Ala Gly Val Ile Gly Pro Ala Glu Gly Thr Lys Pro Arg
565 570 575Lys Val Leu Gln Gln 580133829DNAStreptococcus pneumoniae
133tcaaaaagag aaggaaaact tggttattgc tgggaaaata ggtccagaac
cagaaatttt 60ggccaatatg tataagttgc tgattgaaga aaataccagc atgactgcga
ctgttaaacc 120gaattttggg aagacaagct tcctttatga agctctgaaa
aaaggcgata ttgacatcta 180tcctgaattt actggtacgg tgactgaaag
tttgcttcaa ccatcaccca aggtgagtca 240tgaaccagaa caggtttatc
aggtggcgcg tgatggcatt gctaagcagg atcatctagc 300ctatctcaaa
cccatgtctt atcaaaacac ctatgctgta gctgttccga aaaagattgc
360tcaagaatat ggcttgaaga ccatttcaga cttgaaaaaa gtggaagggc
agttgaaggc 420aggttttaca ctcgagttta acgaccgtga agatggaaat
aagggcttgc aatcaatgta 480tggtctcaat ctcaatgtag cgaccattga
gccagccctt cgctatcagg ctattcagtc 540aggggatatt caaatcacgg
atgcctattc gactgatgcg gaattggagc gttatgattt 600acaggtcttg
gaagatgaca agcaactctt cccaccttat caaggggctc cactcatgaa
660agaagctctt ctcaagaaac acccagagtt ggaaagagtt cttaatacat
tggctggtaa 720gattacagaa agccagatga gccagctcaa ctaccaagtc
ggtgttgaag gcaagtcagc 780aaagcaagta gccaaggagt ttctccaaga
acaaggtttg ttgaagaaa 829134276PRTStreptococcus pneumoniae 134Gln
Lys Glu Lys Glu Asn Leu Val Ile Ala Gly Lys Ile Gly Pro Glu1 5 10
15Pro Glu Ile Leu Ala Asn Met Tyr Lys Leu Leu Ile Glu Glu Asn Thr
20 25 30Ser Met Thr Ala Thr Val Lys Pro Asn Phe Gly Lys Thr Ser Phe
Leu 35 40 45Tyr Glu Ala Leu Lys Lys Gly Asp Ile Asp Ile Tyr Pro Glu
Phe Thr 50 55 60Gly Thr Val Thr Glu Ser Leu Leu Gln Pro Ser Pro Lys
Val Ser His65 70 75 80Glu Pro Glu Gln Val Tyr Gln Val Ala Arg Asp
Gly Ile Ala Lys Gln 85 90 95Asp His Leu Ala Tyr Leu Lys Pro Met Ser
Tyr Gln Asn Thr Tyr Ala 100 105 110Val Ala Val Pro Lys Lys Ile Ala
Gln Glu Tyr Gly Leu Lys Thr Ile 115 120 125Ser Asp Leu Lys Lys Val
Glu Gly Gln Leu Lys Ala Gly Phe Thr Leu 130 135 140Glu Phe Asn Asp
Arg Glu Asp Gly Asn Lys Gly Leu Gln Ser Met Tyr145 150 155 160Gly
Leu Asn Leu Asn Val Ala Thr Ile Glu Pro Ala Leu Arg Tyr Gln 165 170
175Ala Ile Gln Ser Gly Asp Ile Gln Ile Thr Asp Ala Tyr Ser Thr Asp
180 185 190Ala Glu Leu Glu Arg Tyr Asp Leu Gln Val Leu Glu Asp Asp
Lys Gln 195 200 205Leu Phe Pro Pro Tyr Gln Gly Ala Pro Leu Met Lys
Glu Ala Leu Leu 210 215 220Lys Lys His Pro Glu Leu Glu Arg Val Leu
Asn Thr Leu Ala Gly Lys225 230 235 240Ile Thr Glu Ser Gln Met Ser
Gln Leu Asn Tyr Gln Val Gly Val Glu 245 250 255Gly Lys Ser Ala Lys
Gln Val Ala Lys Glu Phe Leu Gln Glu Gln Gly 260 265 270Leu Leu Lys
Lys 275135712DNAStreptococcus pneumoniae 135acgttctatt gaggaccact
ttgattcaaa cttcgaattg gaatataacc tcaaagaaaa 60agggaaaaca gatcttttga
agctagttga taaaacaact gacatgcgtc tgcattttat 120ccgccaaact
catccacgcg gtctcggaga tgctgttttg caagccaagg ctttcgtcgg
180aaatgaacct tttgtcgtta tgcttggtga tgacttgatg gatatcacag
acgaaaaggc 240tgttccactt accaaacaac tcatggatga ctacgagcgt
acccacgcgt ctactatcgc 300tgtcatgcca gtccctcatg acgaagtatc
tgcttacggg gttattgctc cgcaaggcga 360aggaaaagat ggtctttaca
gtgttgaaac ctttgttgaa aaaccagctc cagaggacgc 420tcctagcgac
cttgctatta tcggacgcta cctcctcacg cctgaaattt ttgagattct
480cgaaaagcaa gctccaggtg caggaaatga aattcagctg acagatgcaa
tcgacaccct 540caataaaaca caacgtgtat ttgctcgtga gttcaaaggg
gctcgttacg atgtcggaga 600caagtttggc ttcatgaaaa catccatcga
ctacgccctc aaacacccac aagtcaaaga 660tgatttgaag aattacctca
tccaacttgg aaaagaattg actgagaagg aa 712136237PRTStreptococcus
pneumoniae 136Arg Ser Ile Glu Asp His Phe Asp Ser Asn Phe Glu Leu
Glu Tyr Asn1 5 10 15Leu Lys Glu Lys Gly Lys Thr Asp Leu Leu Lys Leu
Val Asp Lys Thr 20 25 30Thr Asp Met Arg Leu His Phe Ile Arg Gln Thr
His Pro Arg Gly Leu 35 40 45Gly Asp Ala Val Leu Gln Ala Lys Ala Phe
Val Gly Asn Glu Pro Phe 50 55 60Val Val Met Leu Gly Asp Asp Leu Met
Asp Ile Thr Asp Glu Lys Ala65 70 75 80Val Pro Leu Thr Lys Gln Leu
Met Asp Asp Tyr Glu Arg Thr His Ala 85 90 95Ser Thr Ile Ala Val Met
Pro Val Pro His Asp Glu Val Ser Ala Tyr 100 105 110Gly Val Ile Ala
Pro Gln Gly Glu Gly Lys Asp Gly Leu Tyr Ser Val 115 120 125Glu Thr
Phe Val Glu Lys Pro Ala Pro Glu Asp Ala Pro Ser Asp Leu 130 135
140Ala Ile Ile Gly Arg Tyr Leu Leu Thr Pro Glu Ile Phe Glu Ile
Leu145 150 155 160Glu Lys Gln Ala Pro Gly Ala Gly Asn Glu Ile Gln
Leu Thr Asp Ala 165 170 175Ile Asp Thr Leu Asn Lys Thr Gln Arg Val
Phe Ala Arg Glu Phe Lys 180
185 190Gly Ala Arg Tyr Asp Val Gly Asp Lys Phe Gly Phe Met Lys Thr
Ser 195 200 205Ile Asp Tyr Ala Leu Lys His Pro Gln Val Lys Asp Asp
Leu Lys Asn 210 215 220Tyr Leu Ile Gln Leu Gly Lys Glu Leu Thr Glu
Lys Glu225 230 235137502DNAStreptococcus pneumoniae 137cgctcaaaat
accagaggtg ttcagctaat cgagcacgtt tctcctcaaa tgttgaaagc 60ccaattggag
agtgtctttt ctgatattcc acctcaggct gtaaaaactg gaatgttggc
120tactactgaa atcatggaaa tcatccaacc ctatcttaaa aaactggatt
gtccctatgt 180ccttgatcct gttatggttg ctacaagtgg agatgccttg
attgactcaa atgctagaga 240ctatctcaaa acaaacttac tacctctagc
aactattatt acgccaaatc ttcctgaagc 300agaagagatt gttggttttt
caatccatga ccccgaagac atgcagcgtg ctggtcgcct 360gattttaaaa
gaatttggtc ctcagtctgt ggttatcaaa ggcggacatc tcaaaggtgg
420tgctaaagat ttcctcttta ccaagaatga acaatttgtc tgggaaagcc
cacgaattca 480aacctgtcac acccatggta ct 502138167PRTStreptococcus
pneumoniae 138Ala Gln Asn Thr Arg Gly Val Gln Leu Ile Glu His Val
Ser Pro Gln1 5 10 15Met Leu Lys Ala Gln Leu Glu Ser Val Phe Ser Asp
Ile Pro Pro Gln 20 25 30Ala Val Lys Thr Gly Met Leu Ala Thr Thr Glu
Ile Met Glu Ile Ile 35 40 45Gln Pro Tyr Leu Lys Lys Leu Asp Cys Pro
Tyr Val Leu Asp Pro Val 50 55 60Met Val Ala Thr Ser Gly Asp Ala Leu
Ile Asp Ser Asn Ala Arg Asp65 70 75 80Tyr Leu Lys Thr Asn Leu Leu
Pro Leu Ala Thr Ile Ile Thr Pro Asn 85 90 95Leu Pro Glu Ala Glu Glu
Ile Val Gly Phe Ser Ile His Asp Pro Glu 100 105 110Asp Met Gln Arg
Ala Gly Arg Leu Ile Leu Lys Glu Phe Gly Pro Gln 115 120 125Ser Val
Val Ile Lys Gly Gly His Leu Lys Gly Gly Ala Lys Asp Phe 130 135
140Leu Phe Thr Lys Asn Glu Gln Phe Val Trp Glu Ser Pro Arg Ile
Gln145 150 155 160Thr Cys His Thr His Gly Thr
165139805DNAStreptococcus pneumoniae 139aattgtacaa ttagaaaaag
atagcaaatc agacaaagaa caagttgata aactatttga 60atcatttgat gcatcttcag
atgaatctat ttctaaatta aaagaactat ctgaaacttc 120acttaaaacc
gatgcaggta aagactatct taataacaaa gtcaaagaat catctaaagc
180aattgtagat tttcatttgc aaaaaggttt ggcttatgat gttaaagatt
cagatgacaa 240atttaaagat aaagcaactc ttgaaacaaa tgtaaaagaa
attacaaaac aaattgattt 300tatcaaaaaa gttgatgaaa cttttaaaca
agagaatttg gaagaaactc ttaaatctct 360aaatgatctt gttgataaat
atcaaaaaca aatcgaactt ttgaagaaag aagaagaaaa 420agctgctgaa
aaagctgctg aaaaagcaaa ggaatcttct agtcaaagta attcttctgg
480tagtgcttct aatgagtctt ataatggatc ttccaattca aatgtagatt
atagttcatc 540tgaacaaact aatggatatt caaataatta tggcggtcaa
gattattctg gttcaggaga 600tagttcaaca aatggtggat catcagaaca
atattcatct agcaattcaa acagcggagc 660aaataatgtc tacagatata
aaggcactgg tgctgacggc tatcaaagat actactacaa 720agatcataat
aatggagatg tgtatgatga cgatggaaat taccttggga actttggtgg
780cggcattgca gaacctagtc aacgc 805140268PRTStreptococcus pneumoniae
140Ile Val Gln Leu Glu Lys Asp Ser Lys Ser Asp Lys Glu Gln Val Asp1
5 10 15Lys Leu Phe Glu Ser Phe Asp Ala Ser Ser Asp Glu Ser Ile Ser
Lys 20 25 30Leu Lys Glu Leu Ser Glu Thr Ser Leu Lys Thr Asp Ala Gly
Lys Asp 35 40 45Tyr Leu Asn Asn Lys Val Lys Glu Ser Ser Lys Ala Ile
Val Asp Phe 50 55 60His Leu Gln Lys Gly Leu Ala Tyr Asp Val Lys Asp
Ser Asp Asp Lys65 70 75 80Phe Lys Asp Lys Ala Thr Leu Glu Thr Asn
Val Lys Glu Ile Thr Lys 85 90 95Gln Ile Asp Phe Ile Lys Lys Val Asp
Glu Thr Phe Lys Gln Glu Asn 100 105 110Leu Glu Glu Thr Leu Lys Ser
Leu Asn Asp Leu Val Asp Lys Tyr Gln 115 120 125Lys Gln Ile Glu Leu
Leu Lys Lys Glu Glu Glu Lys Ala Ala Glu Lys 130 135 140Ala Ala Glu
Lys Ala Lys Glu Ser Ser Ser Gln Ser Asn Ser Ser Gly145 150 155
160Ser Ala Ser Asn Glu Ser Tyr Asn Gly Ser Ser Asn Ser Asn Val Asp
165 170 175Tyr Ser Ser Ser Glu Gln Thr Asn Gly Tyr Ser Asn Asn Tyr
Gly Gly 180 185 190Gln Asp Tyr Ser Gly Ser Gly Asp Ser Ser Thr Asn
Gly Gly Ser Ser 195 200 205Glu Gln Tyr Ser Ser Ser Asn Ser Asn Ser
Gly Ala Asn Asn Val Tyr 210 215 220Arg Tyr Lys Gly Thr Gly Ala Asp
Gly Tyr Gln Arg Tyr Tyr Tyr Lys225 230 235 240Asp His Asn Asn Gly
Asp Val Tyr Asp Asp Asp Gly Asn Tyr Leu Gly 245 250 255Asn Phe Gly
Gly Gly Ile Ala Glu Pro Ser Gln Arg 260 265141211DNAStreptococcus
pneumoniae 141tctgaccaag caaaaagaag cagtcaatga caaaggaaaa
gcagctgttg ttaaggtggt 60ggaaagccag gcagaacttt atagcttaga aaagaatgaa
gatgctagcc taagaaagtt 120acaagcagat ggacgcatca cggaagaaca
ggctaaagct tataaagaat acaatgataa 180aaatggagga gcaaatcgta
aagtcaatga t 21114270PRTStreptococcus pneumoniae 142Leu Thr Lys Gln
Lys Glu Ala Val Asn Asp Lys Gly Lys Ala Ala Val1 5 10 15Val Lys Val
Val Glu Ser Gln Ala Glu Leu Tyr Ser Leu Glu Lys Asn 20 25 30Glu Asp
Ala Ser Leu Arg Lys Leu Gln Ala Asp Gly Arg Ile Thr Glu 35 40 45Glu
Gln Ala Lys Ala Tyr Lys Glu Tyr Asn Asp Lys Asn Gly Gly Ala 50 55
60Asn Arg Lys Val Asn Asp65 70143331DNAStreptococcus pneumoniae
143gtccggctct gtccagtcca ctttttcagc ggtagaggaa cagattttct
ttatggagtt 60tgaagaactc tatcgggaaa cccaaaaacg cagtgtagcc agtcagcaaa
agactagtct 120gaacttagat gggcagacgc ttagcaatgg cagtcaaaag
ttgccagtcc ctaaaggaat 180tcaggcccca tcaggccaaa gtattacatt
tgaccgagct gggggcaatt cgtccctggc 240taaggttgaa tttcagacca
gtaaaggagc gattcgctat caattatatc taggaaatgg 300aaaaattaaa
cgcattaagg aaacaaaaaa t 331144110PRTStreptococcus pneumoniae 144Ser
Gly Ser Val Gln Ser Thr Phe Ser Ala Val Glu Glu Gln Ile Phe1 5 10
15Phe Met Glu Phe Glu Glu Leu Tyr Arg Glu Thr Gln Lys Arg Ser Val
20 25 30Ala Ser Gln Gln Lys Thr Ser Leu Asn Leu Asp Gly Gln Thr Leu
Ser 35 40 45Asn Gly Ser Gln Lys Leu Pro Val Pro Lys Gly Ile Gln Ala
Pro Ser 50 55 60Gly Gln Ser Ile Thr Phe Asp Arg Ala Gly Gly Asn Ser
Ser Leu Ala65 70 75 80Lys Val Glu Phe Gln Thr Ser Lys Gly Ala Ile
Arg Tyr Gln Leu Tyr 85 90 95Leu Gly Asn Gly Lys Ile Lys Arg Ile Lys
Glu Thr Lys Asn 100 105 110145196DNAStreptococcus pneumoniae
145gggacaaatt caaaaaaata ggcaagagga agcaaaaatc ttgcaaaagg
aagaagtctt 60gagggtagct aagatggccc tgcagacggg gcaaaatcag gtaagcatca
acggagttga 120gattcaggta ttttctagtg aaaaaggatt ggaggtctac
catggttcag aacagttgtt 180ggcaatcaaa gagcca 19614665PRTStreptococcus
pneumoniae 146Gly Gln Ile Gln Lys Asn Arg Gln Glu Glu Ala Lys Ile
Leu Gln Lys1 5 10 15Glu Glu Val Leu Arg Val Ala Lys Met Ala Leu Gln
Thr Gly Gln Asn 20 25 30Gln Val Ser Ile Asn Gly Val Glu Ile Gln Val
Phe Ser Ser Glu Lys 35 40 45Gly Leu Glu Val Tyr His Gly Ser Glu Gln
Leu Leu Ala Ile Lys Glu 50 55 60Pro65147319DNAStreptococcus
pneumoniae 147tcgctaccag caacaaagcg agcaaaagga gtggctcttg
tttgtggacc aacttgaggt 60agaattagac cgttcgcagt tcgaaaaagt agaaggcaat
cgcctataca tgaagcaaga 120tggcaaggac atcgccatcg gtaagtcaaa
gtcagatgat ttccgtaaaa cgaatgctcg 180tggtcgaggt tatcagccta
tggtttatgg actcaaatct gtacggatta cagaggacaa 240tcaactggtt
cgctttcatt tccagttcca aaaaggctta gaaagggagt tcatctatcg
300tgtggaaaaa gaaaaaagt 319148106PRTStreptococcus pneumoniae 148Arg
Tyr Gln Gln Gln Ser Glu Gln Lys Glu Trp Leu Leu Phe Val Asp1 5 10
15Gln Leu Glu Val Glu Leu Asp Arg Ser Gln Phe Glu Lys Val Glu Gly
20 25 30Asn Arg Leu Tyr Met Lys Gln Asp Gly Lys Asp Ile Ala Ile Gly
Lys 35 40 45Ser Lys Ser Asp Asp Phe Arg Lys Thr Asn Ala Arg Gly Arg
Gly Tyr 50 55 60Gln Pro Met Val Tyr Gly Leu Lys Ser Val Arg Ile Thr
Glu Asp Asn65 70 75 80Gln Leu Val Arg Phe His Phe Gln Phe Gln Lys
Gly Leu Glu Arg Glu 85 90 95Phe Ile Tyr Arg Val Glu Lys Glu Lys Ser
100 105149322DNAStreptococcus pneumoniae 149gaaccgacaa gtcgcccact
atcaagacta tgctttgaat aaagaaaaat tggttgcttt 60tgctatggct aaacgaacca
aagataaggt tgagcaagaa agtggggaac agttttttaa 120tctaggtcag
gtaagctatc aaaacaagaa aactggctta gtgacgaggg ttcgtacgga
180taagagccaa tatgagtttc tgtttccttc agtcaaaatc aaagaagaga
aaagagataa 240aaaggaagag gtagcgaccg attcaagcga aaaagtggag
aagaaaaaat cagaagagaa 300gcctgaaaag aaagagaatt ca
322150107PRTStreptococcus pneumoniae 150Asn Arg Gln Val Ala His Tyr
Gln Asp Tyr Ala Leu Asn Lys Glu Lys1 5 10 15Leu Val Ala Phe Ala Met
Ala Lys Arg Thr Lys Asp Lys Val Glu Gln 20 25 30Glu Ser Gly Glu Gln
Phe Phe Asn Leu Gly Gln Val Ser Tyr Gln Asn 35 40 45Lys Lys Thr Gly
Leu Val Thr Arg Val Arg Thr Asp Lys Ser Gln Tyr 50 55 60Glu Phe Leu
Phe Pro Ser Val Lys Ile Lys Glu Glu Lys Arg Asp Lys65 70 75 80Lys
Glu Glu Val Ala Thr Asp Ser Ser Glu Lys Val Glu Lys Lys Lys 85 90
95Ser Glu Glu Lys Pro Glu Lys Lys Glu Asn Ser 100
105151784DNAStreptococcus pneumoniae 151ggttgtcggc tggcaatata
tcccgtttcc atctaaaggt agtacaattg gtccttaccc 60aaatggtatc agattagaag
gttttccaaa gtcagagtgg tactacttcg ataaaaatgg 120agtgctacaa
gagtttgttg gttggaaaac attagagatt aaaactaaag acagtgttgg
180aagaaagtac ggggaaaaac gtgaagattc agaagataaa gaagagaagc
gttattatac 240gaactattac tttaatcaaa atcattcttt agagacaggt
tggctttatg atcagtctaa 300ctggtattat ctagctaaga cggaaattaa
tggagaaaac taccttggtg gtgaaagacg 360tgcggggtgg ataaacgatg
attcgacttg gtactaccta gatccaacaa ctggtattat 420gcaaacaggt
tggcaatatc taggtaataa gtggtactac ctccgttcct caggagcaat
480ggccactggc tggtatcagg aaggtaccac ttggtattat ttagaccacc
caaatggcga 540tatgaaaaca ggttggcaaa accttgggaa caaatggtac
tatctccgtt catcaggagc 600tatggcaact ggttggtatc aagatggttc
aacttggtac tacctaaatg caggtaatgg 660agacatgaag acaggttggt
tccaggtcaa tggcaactgg tactatgctt atagctcagg 720tgctttggca
gtgaatacga ccgtagatgg ctattctgtc aactataatg gcgaatgggt 780tcgg
784152261PRTStreptococcus pneumoniae 152Val Val Gly Trp Gln Tyr Ile
Pro Phe Pro Ser Lys Gly Ser Thr Ile1 5 10 15Gly Pro Tyr Pro Asn Gly
Ile Arg Leu Glu Gly Phe Pro Lys Ser Glu 20 25 30Trp Tyr Tyr Phe Asp
Lys Asn Gly Val Leu Gln Glu Phe Val Gly Trp 35 40 45Lys Thr Leu Glu
Ile Lys Thr Lys Asp Ser Val Gly Arg Lys Tyr Gly 50 55 60Glu Lys Arg
Glu Asp Ser Glu Asp Lys Glu Glu Lys Arg Tyr Tyr Thr65 70 75 80Asn
Tyr Tyr Phe Asn Gln Asn His Ser Leu Glu Thr Gly Trp Leu Tyr 85 90
95Asp Gln Ser Asn Trp Tyr Tyr Leu Ala Lys Thr Glu Ile Asn Gly Glu
100 105 110Asn Tyr Leu Gly Gly Glu Arg Arg Ala Gly Trp Ile Asn Asp
Asp Ser 115 120 125Thr Trp Tyr Tyr Leu Asp Pro Thr Thr Gly Ile Met
Gln Thr Gly Trp 130 135 140Gln Tyr Leu Gly Asn Lys Trp Tyr Tyr Leu
Arg Ser Ser Gly Ala Met145 150 155 160Ala Thr Gly Trp Tyr Gln Glu
Gly Thr Thr Trp Tyr Tyr Leu Asp His 165 170 175Pro Asn Gly Asp Met
Lys Thr Gly Trp Gln Asn Leu Gly Asn Lys Trp 180 185 190Tyr Tyr Leu
Arg Ser Ser Gly Ala Met Ala Thr Gly Trp Tyr Gln Asp 195 200 205Gly
Ser Thr Trp Tyr Tyr Leu Asn Ala Gly Asn Gly Asp Met Lys Thr 210 215
220Gly Trp Phe Gln Val Asn Gly Asn Trp Tyr Tyr Ala Tyr Ser Ser
Gly225 230 235 240Ala Leu Ala Val Asn Thr Thr Val Asp Gly Tyr Ser
Val Asn Tyr Asn 245 250 255Gly Glu Trp Val Arg
2601531708DNAStreptococcus pneumoniae 153ggccaaatca gaatgggtag
aagacaaggg agccttttat tatcttgacc aagatggaaa 60gatgaaaaga aatgcttggg
taggaacttc ctatgttggt gcaacaggtg ccaaagtaat 120agaagactgg
gtctatgatt ctcaatacga tgcttggttt tatatcaaag cagatggaca
180gcacgcagag aaagaatggc tccaaattaa agggaaggac tattatttca
aatccggtgg 240ttatctactg acaagtcagt ggattaatca agcttatgtg
aatgctagtg gtgccaaagt 300acagcaaggt tggctttttg acaaacaata
ccaatcttgg ttttacatca aagaaaatgg 360aaactatgct gataaagaat
ggattttcga gaatggtcac tattattatc taaaatccgg 420tggctacatg
gcagccaatg aatggatttg ggataaggaa tcttggtttt atctcaaatt
480tgatgggaaa atggctgaaa aagaatgggt ctacgattct catagtcaag
cttggtacta 540cttcaaatcc ggtggttaca tgacagccaa tgaatggatt
tgggataagg aatcttggtt 600ttatctcaaa tctgatggga aaatagctga
aaaagaatgg gtctacgatt ctcatagtca 660agcttggtac tacttcaaat
ccggtggtta catgacagcc aatgaatgga tttgggataa 720ggaatcttgg
ttttacctca aatctgatgg gaaaatagct gaaaaagaat gggtctacga
780ttctcatagt caagcttggt actacttcaa atctggtggc tacatggcga
aaaatgagac 840agtagatggt tatcagcttg gaagcgatgg taaatggctt
ggaggaaaaa ctacaaatga 900aaatgctgct tactatcaag tagtgcctgt
tacagccaat gtttatgatt cagatggtga 960aaagctttcc tatatatcgc
aaggtagtgt cgtatggcta gataaggata gaaaaagtga 1020tgacaagcgc
ttggctatta ctatttctgg tttgtcaggc tatatgaaaa cagaagattt
1080acaagcgcta gatgctagta aggactttat cccttattat gagagtgatg
gccaccgttt 1140ttatcactat gtggctcaga atgctagtat cccagtagct
tctcatcttt ctgatatgga 1200agtaggcaag aaatattatt cggcagatgg
cctgcatttt gatggtttta agcttgagaa 1260tcccttcctt ttcaaagatt
taacagaggc tacaaactac agtgctgaag aattggataa 1320ggtatttagt
ttgctaaaca ttaacaatag ccttttggag aacaagggcg ctacttttaa
1380ggaagccgaa gaacattacc atatcaatgc tctttatctc cttgcccata
gtgccctaga 1440aagtaactgg ggaagaagta aaattgccaa agataagaat
aatttctttg gcattacagc 1500ctatgatacg accccttacc tttctgctaa
gacatttgat gatgtggata agggaatttt 1560aggtgcaacc aagtggatta
aggaaaatta tatcgatagg ggaagaactt tccttggaaa 1620caaggcttct
ggtatgaatg tggaatatgc ttcagaccct tattggggcg aaaaaattgc
1680tagtgtgatg atgaaaatca atgagaag 1708154569PRTStreptococcus
pneumoniae 154Ala Lys Ser Glu Trp Val Glu Asp Lys Gly Ala Phe Tyr
Tyr Leu Asp1 5 10 15Gln Asp Gly Lys Met Lys Arg Asn Ala Trp Val Gly
Thr Ser Tyr Val 20 25 30Gly Ala Thr Gly Ala Lys Val Ile Glu Asp Trp
Val Tyr Asp Ser Gln 35 40 45Tyr Asp Ala Trp Phe Tyr Ile Lys Ala Asp
Gly Gln His Ala Glu Lys 50 55 60Glu Trp Leu Gln Ile Lys Gly Lys Asp
Tyr Tyr Phe Lys Ser Gly Gly65 70 75 80Tyr Leu Leu Thr Ser Gln Trp
Ile Asn Gln Ala Tyr Val Asn Ala Ser 85 90 95Gly Ala Lys Val Gln Gln
Gly Trp Leu Phe Asp Lys Gln Tyr Gln Ser 100 105 110Trp Phe Tyr Ile
Lys Glu Asn Gly Asn Tyr Ala Asp Lys Glu Trp Ile 115 120 125Phe Glu
Asn Gly His Tyr Tyr Tyr Leu Lys Ser Gly Gly Tyr Met Ala 130 135
140Ala Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr Leu Lys
Phe145 150 155 160Asp Gly Lys Met Ala Glu Lys Glu Trp Val Tyr Asp
Ser His Ser Gln 165 170 175Ala Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr
Met Thr Ala Asn Glu Trp 180 185 190Ile Trp Asp Lys Glu Ser Trp Phe
Tyr Leu Lys Ser Asp Gly Lys Ile 195 200 205Ala Glu Lys Glu Trp Val
Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr 210 215 220Phe Lys Ser Gly
Gly Tyr Met Thr Ala Asn Glu Trp Ile Trp Asp Lys225 230 235 240Glu
Ser Trp Phe Tyr Leu Lys Ser Asp Gly Lys Ile Ala Glu Lys Glu 245 250
255Trp Val Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly
260 265 270Gly Tyr Met Ala Lys Asn Glu Thr Val Asp
Gly Tyr Gln Leu Gly Ser 275 280 285Asp Gly Lys Trp Leu Gly Gly Lys
Thr Thr Asn Glu Asn Ala Ala Tyr 290 295 300Tyr Gln Val Val Pro Val
Thr Ala Asn Val Tyr Asp Ser Asp Gly Glu305 310 315 320Lys Leu Ser
Tyr Ile Ser Gln Gly Ser Val Val Trp Leu Asp Lys Asp 325 330 335Arg
Lys Ser Asp Asp Lys Arg Leu Ala Ile Thr Ile Ser Gly Leu Ser 340 345
350Gly Tyr Met Lys Thr Glu Asp Leu Gln Ala Leu Asp Ala Ser Lys Asp
355 360 365Phe Ile Pro Tyr Tyr Glu Ser Asp Gly His Arg Phe Tyr His
Tyr Val 370 375 380Ala Gln Asn Ala Ser Ile Pro Val Ala Ser His Leu
Ser Asp Met Glu385 390 395 400Val Gly Lys Lys Tyr Tyr Ser Ala Asp
Gly Leu His Phe Asp Gly Phe 405 410 415Lys Leu Glu Asn Pro Phe Leu
Phe Lys Asp Leu Thr Glu Ala Thr Asn 420 425 430Tyr Ser Ala Glu Glu
Leu Asp Lys Val Phe Ser Leu Leu Asn Ile Asn 435 440 445Asn Ser Leu
Leu Glu Asn Lys Gly Ala Thr Phe Lys Glu Ala Glu Glu 450 455 460His
Tyr His Ile Asn Ala Leu Tyr Leu Leu Ala His Ser Ala Leu Glu465 470
475 480Ser Asn Trp Gly Arg Ser Lys Ile Ala Lys Asp Lys Asn Asn Phe
Phe 485 490 495Gly Ile Thr Ala Tyr Asp Thr Thr Pro Tyr Leu Ser Ala
Lys Thr Phe 500 505 510Asp Asp Val Asp Lys Gly Ile Leu Gly Ala Thr
Lys Trp Ile Lys Glu 515 520 525Asn Tyr Ile Asp Arg Gly Arg Thr Phe
Leu Gly Asn Lys Ala Ser Gly 530 535 540Met Asn Val Glu Tyr Ala Ser
Asp Pro Tyr Trp Gly Glu Lys Ile Ala545 550 555 560Ser Val Met Met
Lys Ile Asn Glu Lys 565155946DNAStreptococcus pneumoniae
155atttgcagat gattctgaag gatggcagtt tgtccaagaa aatggtagaa
cctactacaa 60aaagggggat ctaaaagaaa cctactggag agtgatagat gggaagtact
attattttga 120tcctttatcc ggagagatgg ttgtcggctg gcaatatata
cctgctccac acaagggggt 180tacgattggt ccttctccaa gaatagagat
tgctcttaga ccagattggt tttattttgg 240tcaagatggt gtattacaag
aatttgttgg caagcaagtt ttagaagcaa aaactgctac 300gaataccaac
aaacatcatg gggaagaata tgatagccaa gcagagaaac gagtctatta
360ttttgaagat cagcgtagtt atcatacttt aaaaactggt tggatttatg
aagagggtca 420ttggtattat ttacagaagg atggtggctt tgattcgcgc
atcaacagat tgacggttgg 480agagctagca cgtggttggg ttaaggatta
ccctcttacg tatgatgaag agaagctaaa 540agcagctcca tggtactatc
taaatccagc aactggcatt atgcaaacag gttggcaata 600tctaggtaat
agatggtact acctccattc gtcaggagct atggcaactg gctggtataa
660ggaaggctca acttggtact atctagatgc tgaaaatggt gatatgagaa
ctggctggca 720aaaccttggg aacaaatggt actatctccg ttcatcagga
gctatggcaa ctggttggta 780tcaggaaagt tcgacttggt actatctaaa
tgcaagtaat ggagatatga aaacaggctg 840gttccaagtc aatggtaact
ggtactatgc ctatgattca ggtgctttag ctgttaatac 900cacagtaggt
ggttactact taaactataa tggtgaatgg gttaag 946156316PRTStreptococcus
pneumoniae 156Val Phe Ala Asp Asp Ser Glu Gly Trp Gln Phe Val Gln
Glu Asn Gly1 5 10 15Arg Thr Tyr Tyr Lys Lys Gly Asp Leu Lys Glu Thr
Tyr Trp Arg Val 20 25 30Ile Asp Gly Lys Tyr Tyr Tyr Phe Asp Pro Leu
Ser Gly Glu Met Val 35 40 45Val Gly Trp Gln Tyr Ile Pro Ala Pro His
Lys Gly Val Thr Ile Gly 50 55 60Pro Ser Pro Arg Ile Glu Ile Ala Leu
Arg Pro Asp Trp Phe Tyr Phe65 70 75 80Gly Gln Asp Gly Val Leu Gln
Glu Phe Val Gly Lys Gln Val Leu Glu 85 90 95Ala Lys Thr Ala Thr Asn
Thr Asn Lys His His Gly Glu Glu Tyr Asp 100 105 110Ser Gln Ala Glu
Lys Arg Val Tyr Tyr Phe Glu Asp Gln Arg Ser Tyr 115 120 125His Thr
Leu Lys Thr Gly Trp Ile Tyr Glu Glu Gly His Trp Tyr Tyr 130 135
140Leu Gln Lys Asp Gly Gly Phe Asp Ser Arg Ile Asn Arg Leu Thr
Val145 150 155 160Gly Glu Leu Ala Arg Gly Trp Val Lys Asp Tyr Pro
Leu Thr Tyr Asp 165 170 175Glu Glu Lys Leu Lys Ala Ala Pro Trp Tyr
Tyr Leu Asn Pro Ala Thr 180 185 190Gly Ile Met Gln Thr Gly Trp Gln
Tyr Leu Gly Asn Arg Trp Tyr Tyr 195 200 205Leu His Ser Ser Gly Ala
Met Ala Thr Gly Trp Tyr Lys Glu Gly Ser 210 215 220Thr Trp Tyr Tyr
Leu Asp Ala Glu Asn Gly Asp Met Arg Thr Gly Trp225 230 235 240Gln
Asn Leu Gly Asn Lys Trp Tyr Tyr Leu Arg Ser Ser Gly Ala Met 245 250
255Ala Thr Gly Trp Tyr Gln Glu Ser Ser Thr Trp Tyr Tyr Leu Asn Ala
260 265 270Ser Asn Gly Asp Met Lys Thr Gly Trp Phe Gln Val Asn Gly
Asn Trp 275 280 285Tyr Tyr Ala Tyr Asp Ser Gly Ala Leu Ala Val Asn
Thr Thr Val Gly 290 295 300Gly Tyr Tyr Leu Asn Tyr Asn Gly Glu Trp
Val Lys305 310 3151571415DNAStreptococcus pneumoniae 157tgtcgctgca
aatgaaactg aagtagcaaa aacttcgcag gatacaacga cagcttcaag 60tagttcagag
caaaatcagt cttctaataa aacgcaaacg agcgcagaag tacagactaa
120tgctgctgcc cactgggatg gggattatta tgtaaaggat gatggttcta
aagctcaaag 180tgaatggatt tttgacaact actataaggc ttggttttat
attaattcag atggtcgtta 240ctcgcagaat gaatggcatg gaaattacta
cctgaaatca ggtggatata tggcccaaaa 300cgagtggatc tatgacagta
attacaagag ttggttttat ctcaagtcag atggggctta 360tgctcatcaa
gaatggcaat tgattggaaa taagtggtac tacttcaaga agtggggtta
420catggctaaa agccaatggc aaggaagtta tttcttgaat ggtcaaggag
ctatgatgca 480aaatgaatgg ctsctatgat ccagcctatt ctgcttattt
ttatctaaaa tccgatggaa 540cttatgctaa ccaagagtgg caaaaagtgg
gcggcaaatg gtactatttc aagaagtggg 600gctatatggc tcggaatgag
tggcaaggca actactattt gactggaagt ggtgccatgg 660cgactgacga
agtgattatg gatggtactc gctatatctt tgcggcctct ggtgagctca
720aagaaaaaaa agatttgaat gtcggctggg ttcacagaga tggtaagcgc
tatttcttta 780ataatagaga agaacaagtg ggaaccgaac atgctaagaa
agtcattgat attagtgagc 840acaatggtcg tatcaatgat tggaaaaagg
ttattgatga gaacgaagtg gatggtgtca 900ttgttcgtct aggttatagc
ggtaaagaag acaaggaatt ggcgcataac attaaggagt 960taaaccgtct
gggaattcct tatggtgtct atctctatac ctatgctgaa aatgagaccg
1020atgctgagag tgacgctaaa cagaccattg aacttataaa gaaatacaat
atgaacctgt 1080cttaccctat ctattatgat gttgagaatt gggaatatgt
aaataagagc aagagagctc 1140caagtgatac aggcacttgg gttaaaatca
tcaacaagta catggacacg atgaagcagg 1200cgggttatca aaatgtgtat
gtctatagct atcgtagttt attacagacg cgtttaaaac 1260acccagatat
tttaaaacat gtaaactggg tagcggccta tacgaatgct ttagaatggg
1320aaaaccctca ttattcagga aaaaaaggtt ggcaatatac ctcttctgaa
tacatgaaag 1380gaatccaagg gcgcgtagat gtcagcgttt ggtat
1415158471PRTStreptococcus pneumoniae 158Val Ala Ala Asn Glu Thr
Glu Val Ala Lys Thr Ser Gln Asp Thr Thr1 5 10 15Thr Ala Ser Ser Ser
Ser Glu Gln Asn Gln Ser Ser Asn Lys Thr Gln 20 25 30Thr Ser Ala Glu
Val Gln Thr Asn Ala Ala Ala His Trp Asp Gly Asp 35 40 45Tyr Tyr Val
Lys Asp Asp Gly Ser Lys Ala Gln Ser Glu Trp Ile Phe 50 55 60Asp Asn
Tyr Tyr Lys Ala Trp Phe Tyr Ile Asn Ser Asp Gly Arg Tyr65 70 75
80Ser Gln Asn Glu Trp His Gly Asn Tyr Tyr Leu Lys Ser Gly Gly Tyr
85 90 95Met Ala Gln Asn Glu Trp Ile Tyr Asp Ser Asn Tyr Lys Ser Trp
Phe 100 105 110Tyr Leu Lys Ser Asp Gly Ala Tyr Ala His Gln Glu Trp
Gln Leu Ile 115 120 125Gly Asn Lys Trp Tyr Tyr Phe Lys Lys Trp Gly
Tyr Met Ala Lys Ser 130 135 140Gln Trp Gln Gly Ser Tyr Phe Leu Asn
Gly Gln Gly Ala Met Met Gln145 150 155 160Asn Glu Trp Leu Tyr Asp
Pro Ala Tyr Ser Ala Tyr Phe Tyr Leu Lys 165 170 175Ser Asp Gly Thr
Tyr Ala Asn Gln Glu Trp Gln Lys Val Gly Gly Lys 180 185 190Trp Tyr
Tyr Phe Lys Lys Trp Gly Tyr Met Ala Arg Asn Glu Trp Gln 195 200
205Gly Asn Tyr Tyr Leu Thr Gly Ser Gly Ala Met Ala Thr Asp Glu Val
210 215 220Ile Met Asp Gly Thr Arg Tyr Ile Phe Ala Ala Ser Gly Glu
Leu Lys225 230 235 240Glu Lys Lys Asp Leu Asn Val Gly Trp Val His
Arg Asp Gly Lys Arg 245 250 255Tyr Phe Phe Asn Asn Arg Glu Glu Gln
Val Gly Thr Glu His Ala Lys 260 265 270Lys Val Ile Asp Ile Ser Glu
His Asn Gly Arg Ile Asn Asp Trp Lys 275 280 285Lys Val Ile Asp Glu
Asn Glu Val Asp Gly Val Ile Val Arg Leu Gly 290 295 300Tyr Ser Gly
Lys Glu Asp Lys Glu Leu Ala His Asn Ile Lys Glu Leu305 310 315
320Asn Arg Leu Gly Ile Pro Tyr Gly Val Tyr Leu Tyr Thr Tyr Ala Glu
325 330 335Asn Glu Thr Asp Ala Glu Ser Asp Ala Lys Gln Thr Ile Glu
Leu Ile 340 345 350Lys Lys Tyr Asn Met Asn Leu Ser Tyr Pro Ile Tyr
Tyr Asp Val Glu 355 360 365Asn Trp Glu Tyr Val Asn Lys Ser Lys Arg
Ala Pro Ser Asp Thr Gly 370 375 380Thr Trp Val Lys Ile Ile Asn Lys
Tyr Met Asp Thr Met Lys Gln Ala385 390 395 400Gly Tyr Gln Asn Val
Tyr Val Tyr Ser Tyr Arg Ser Leu Leu Gln Thr 405 410 415Arg Leu Lys
His Pro Asp Ile Leu Lys His Val Asn Trp Val Ala Ala 420 425 430Tyr
Thr Asn Ala Leu Glu Trp Glu Asn Pro His Tyr Ser Gly Lys Lys 435 440
445Gly Trp Gln Tyr Thr Ser Ser Glu Tyr Met Lys Gly Ile Gln Gly Arg
450 455 460Val Asp Val Ser Val Trp Tyr465
4701591924DNAStreptococcus pneumoniaemisc_feature(917)..(917)n is
a, c, g, or t 159tacgtctcag cctacttttg taagagcaga agaatctcca
caagttgtcg aaaaatcttc 60attagagaag aaatatgagg aagcaaaagc aaaagctgat
actgccaaga aagattacga 120aacggctaaa aagaaagcag aagacgctca
gaaaaagtat gaagatgatc agaagagaac 180tgaggagaaa gctcgaaaag
aagcagaagc atctcaaaaa ttgaatgatg tggcgcttgt 240tgttcaaaat
gcatataaag agtaccgaga agttcaaaat caacgtagta aatataaatc
300tgacgctgaa tatcagaaaa aattaacaga ggtcgactct aaaatagaga
aggctaggaa 360agagcaacag gacttgcaaa ataaatttaa tgaagtaaga
gcagttgtag ttcctgaacc 420aaatgcgttg gctgagacta agaaaaaagc
agaagaagct aaagcagaag aaaaagtagc 480taagagaaaa tatgattatg
caactctaaa ggtagcacta gcgaagaaag aagtagaggc 540taaggaactt
gaaattgaaa aacttcaata tgaaatttct actttggaac aagaagttgc
600tactgctcaa catcaagtag ataatttgaa aaaacttctt gctggtgcgg
atcctgatga 660tggcacagaa gttatagaag ctaaattaaa aaaaggagaa
gctgagctaa acgctaaaca 720agctgagtta gcaaaaaaac aaacagaact
tgaaaaactt cttgacagcc ttgatcctga 780aggtaagact caggatgaat
tagataaaga agcagaagaa gctgagttgg ataaaaaagc 840tgatgaactt
caaaataaag ttgctgattt agaaaaagaa attagtaacc ttgaaatatt
900acttggaggg gctgatnctg aagatgatac tgctgctctt caaaataaat
tagctactaa 960aaaagctgaa ttggaaaaaa ctcaaaaaga attagatgca
gctcttaatg agttaggccc 1020tgatggagat gaagaagaaa ctccagcgcc
ggctcctcaa ccagagcaac cagctcctgc 1080accaaaacca gagcaaccag
ctccagctcc aaaaccagag caaccagctc ctgcaccaaa 1140accagagcaa
ccagctccag ctccaaaacc agagcaacca gctccagctc caaaaccaga
1200gcaaccagct aagccggaga aaccagctga agagcctact caaccagaaa
aaccagccac 1260tccaaaaaca ggctggaaac aagaaaacgg tatgtggtat
ttctacaata ctgatggttc 1320aatggcaata ggttggctcc aaaacaacgg
ttcatggtac tacctaaacg ctaacggcgc 1380tatggcaaca ggttgggtga
aagatggaga tacctggtac tatcttgaag catcaggtgc 1440tatgaaagca
agccaatggt tcaaagtatc agataaatgg tactatgtca acagcaatgg
1500cgctatggcg acaggctggc tccaatacaa tggctcatgg tactacctca
acgctaatgg 1560tgatatggcg acaggatggc tccaatacaa cggttcatgg
tattacctca acgctaatgg 1620tgatatggcg acaggatggg ctaaagtcaa
cggttcatgg tactacctaa acgctaacgg 1680tgctatggct acaggttggg
ctaaagtcaa cggttcatgg tactacctaa acgctaacgg 1740ttcaatggca
acaggttggg tgaaagatgg agatacctgg tactatcttg aagcatcagg
1800tgctatgaaa gcaagccaat ggttcaaagt atcagataaa tggtactatg
tcaatggctt 1860aggtgccctt gcagtcaaca caactgtaga tggctataaa
gtcaatgcca atggtgaatg 1920ggtt 1924160641PRTStreptococcus
pneumoniaeSITE(306)..(306)Xaa can be any naturally occurring amino
acid 160Thr Ser Gln Pro Thr Phe Val Arg Ala Glu Glu Ser Pro Gln Val
Val1 5 10 15Glu Lys Ser Ser Leu Glu Lys Lys Tyr Glu Glu Ala Lys Ala
Lys Ala 20 25 30Asp Thr Ala Lys Lys Asp Tyr Glu Thr Ala Lys Lys Lys
Ala Glu Asp 35 40 45Ala Gln Lys Lys Tyr Glu Asp Asp Gln Lys Arg Thr
Glu Glu Lys Ala 50 55 60Arg Lys Glu Ala Glu Ala Ser Gln Lys Leu Asn
Asp Val Ala Leu Val65 70 75 80Val Gln Asn Ala Tyr Lys Glu Tyr Arg
Glu Val Gln Asn Gln Arg Ser 85 90 95Lys Tyr Lys Ser Asp Ala Glu Tyr
Gln Lys Lys Leu Thr Glu Val Asp 100 105 110Ser Lys Ile Glu Lys Ala
Arg Lys Glu Gln Gln Asp Leu Gln Asn Lys 115 120 125Phe Asn Glu Val
Arg Ala Val Val Val Pro Glu Pro Asn Ala Leu Ala 130 135 140Glu Thr
Lys Lys Lys Ala Glu Glu Ala Lys Ala Glu Glu Lys Val Ala145 150 155
160Lys Arg Lys Tyr Asp Tyr Ala Thr Leu Lys Val Ala Leu Ala Lys Lys
165 170 175Glu Val Glu Ala Lys Glu Leu Glu Ile Glu Lys Leu Gln Tyr
Glu Ile 180 185 190Ser Thr Leu Glu Gln Glu Val Ala Thr Ala Gln His
Gln Val Asp Asn 195 200 205Leu Lys Lys Leu Leu Ala Gly Ala Asp Pro
Asp Asp Gly Thr Glu Val 210 215 220Ile Glu Ala Lys Leu Lys Lys Gly
Glu Ala Glu Leu Asn Ala Lys Gln225 230 235 240Ala Glu Leu Ala Lys
Lys Gln Thr Glu Leu Glu Lys Leu Leu Asp Ser 245 250 255Leu Asp Pro
Glu Gly Lys Thr Gln Asp Glu Leu Asp Lys Glu Ala Glu 260 265 270Glu
Ala Glu Leu Asp Lys Lys Ala Asp Glu Leu Gln Asn Lys Val Ala 275 280
285Asp Leu Glu Lys Glu Ile Ser Asn Leu Glu Ile Leu Leu Gly Gly Ala
290 295 300Asp Xaa Glu Asp Asp Thr Ala Ala Leu Gln Asn Lys Leu Ala
Thr Lys305 310 315 320Lys Ala Glu Leu Glu Lys Thr Gln Lys Glu Leu
Asp Ala Ala Leu Asn 325 330 335Glu Leu Gly Pro Asp Gly Asp Glu Glu
Glu Thr Pro Ala Pro Ala Pro 340 345 350Gln Pro Glu Gln Pro Ala Pro
Ala Pro Lys Pro Glu Gln Pro Ala Pro 355 360 365Ala Pro Lys Pro Glu
Gln Pro Ala Pro Ala Pro Lys Pro Glu Gln Pro 370 375 380Ala Pro Ala
Pro Lys Pro Glu Gln Pro Ala Pro Ala Pro Lys Pro Glu385 390 395
400Gln Pro Ala Lys Pro Glu Lys Pro Ala Glu Glu Pro Thr Gln Pro Glu
405 410 415Lys Pro Ala Thr Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly
Met Trp 420 425 430Tyr Phe Tyr Asn Thr Asp Gly Ser Met Ala Ile Gly
Trp Leu Gln Asn 435 440 445Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn
Gly Ala Met Ala Thr Gly 450 455 460Trp Val Lys Asp Gly Asp Thr Trp
Tyr Tyr Leu Glu Ala Ser Gly Ala465 470 475 480Met Lys Ala Ser Gln
Trp Phe Lys Val Ser Asp Lys Trp Tyr Tyr Val 485 490 495Asn Ser Asn
Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser 500 505 510Trp
Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Leu Gln 515 520
525Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr
530 535 540Gly Trp Ala Lys Val Asn Gly Ser Trp Tyr Tyr Leu Asn Ala
Asn Gly545 550 555 560Ala Met Ala Thr Gly Trp Ala Lys Val Asn Gly
Ser Trp Tyr Tyr Leu 565 570 575Asn Ala Asn Gly Ser Met Ala Thr Gly
Trp Val Lys Asp Gly Asp Thr 580 585 590Trp Tyr Tyr Leu Glu Ala Ser
Gly Ala Met Lys Ala Ser Gln Trp Phe 595 600 605Lys Val Ser Asp Lys
Trp Tyr Tyr Val Asn Gly Leu Gly Ala Leu Ala 610 615 620Val Asn Thr
Thr Val Asp Gly Tyr Lys Val Asn Ala Asn Gly Glu Trp625 630
635 640Val161670DNAStreptococcus pneumoniaemisc_feature(99)..(99)n
is a, c, g, or t 161tggacaggtg aaaggtcatg ctacatttgt gaaatccatg
acaactgaaa tgtaccaaga 60acaacagaac cattctctcg cctacaatca acgcttggnt
tcgcaaaatc gcattgtaga 120tccttttttg gcggagggat atgaggtcaa
ttaccaagtg tctgacgacc ctgatgcagt 180ctatggttac ttgtctattc
caagtttgga aatcatggag ccggtttatt tgggagcaga 240ttatcatcat
ttagggatgg gcttggctca tgtggatggt acaccgctgc ctctggatgg
300tacagggatt cgctcagtga ttgctgggca ccgtgcagag ccaagccatg
tctttttccg 360ccatttggat cagctaaaag ttggagatgc tctttattat
gataatggcc aggaaattgt 420agaatatcag atgatggaca cagagattat
tttaccgtcg gaatgggaaa aattagaatc 480ggttagctct aaaaatatca
tgaccttgat aacctgcgat ccgattccta cctttaataa 540acgcttatta
gtgaattttg aacgagtcgc tgtttatcaa aaatcagatc cacaaacagc
600tgcagttgcg agggttgctt ttacgaaaga aggacaatct gtatcgcgtg
ttgcaacctc 660tcaatggttg 670162223PRTStreptococcus
pneumoniaeSITE(33)..(33)Xaa can be any naturally occurring amino
acid 162Gly Gln Val Lys Gly His Ala Thr Phe Val Lys Ser Met Thr Thr
Glu1 5 10 15Met Tyr Gln Glu Gln Gln Asn His Ser Leu Ala Tyr Asn Gln
Arg Leu 20 25 30Xaa Ser Gln Asn Arg Ile Val Asp Pro Phe Leu Ala Glu
Gly Tyr Glu 35 40 45Val Asn Tyr Gln Val Ser Asp Asp Pro Asp Ala Val
Tyr Gly Tyr Leu 50 55 60Ser Ile Pro Ser Leu Glu Ile Met Glu Pro Val
Tyr Leu Gly Ala Asp65 70 75 80Tyr His His Leu Gly Met Gly Leu Ala
His Val Asp Gly Thr Pro Leu 85 90 95Pro Leu Asp Gly Thr Gly Ile Arg
Ser Val Ile Ala Gly His Arg Ala 100 105 110Glu Pro Ser His Val Phe
Phe Arg His Leu Asp Gln Leu Lys Val Gly 115 120 125Asp Ala Leu Tyr
Tyr Asp Asn Gly Gln Glu Ile Val Glu Tyr Gln Met 130 135 140Met Asp
Thr Glu Ile Ile Leu Pro Ser Glu Trp Glu Lys Leu Glu Ser145 150 155
160Val Ser Ser Lys Asn Ile Met Thr Leu Ile Thr Cys Asp Pro Ile Pro
165 170 175Thr Phe Asn Lys Arg Leu Leu Val Asn Phe Glu Arg Val Ala
Val Tyr 180 185 190Gln Lys Ser Asp Pro Gln Thr Ala Ala Val Ala Arg
Val Ala Phe Thr 195 200 205Lys Glu Gly Gln Ser Val Ser Arg Val Ala
Thr Ser Gln Trp Leu 210 215 220163784DNAStreptococcus pneumoniae
163gattgctcct ttgaaggatt tgagagaaac catgttggaa attgcttctg
gtgctcaaaa 60tcttcgtgcc aaggaagttg gtgcctatga actgagagaa gtaactcgcc
aatttaatgc 120tatgttggat cagattgatc agttgatggt agctattcgt
agccaggaag aaacgacccg 180tcagtaccaa cttcaagccc tttcgagcca
gattaatcca catttcctct ataacacttt 240ggacaccatc atctggatgg
ctgaatttca tgatagtcag cgagtggtgc aggtgaccaa 300gtccttggca
acctatttcc gcttggcgct caatcaaggc aaggacttga tttgtctctc
360tgacgaaatc aatcatgtcc gccagtatct ctttatccag aaacaacgct
atggagataa 420gctggaatac gaaattaatg aaaatgttgc ctttgataat
ttagtcttac ccaagctggt 480cctacaaccc cttgtagaaa atgctcttta
ccatggcatt aaggaaaagg aaggtcaggg 540ccatattaaa ctttctgtcc
agaaacagga ttcgggattg gtcatccgta ttgaggatga 600tggcgttggc
ttccaagatg ctggtgatag tagtcaaagt caactcaaac gtgggggagt
660tggtcttcaa aatgtcgatc aacggctcaa acttcatttt ggagccaatt
accatatgaa 720gattgattct agaccccaaa aagggacgaa agttgaaata
tatataaata gaatagaaac 780tagc 784164261PRTStreptococcus pneumoniae
164Ile Ala Pro Leu Lys Asp Leu Arg Glu Thr Met Leu Glu Ile Ala Ser1
5 10 15Gly Ala Gln Asn Leu Arg Ala Lys Glu Val Gly Ala Tyr Glu Leu
Arg 20 25 30Glu Val Thr Arg Gln Phe Asn Ala Met Leu Asp Gln Ile Asp
Gln Leu 35 40 45Met Val Ala Ile Arg Ser Gln Glu Glu Thr Thr Arg Gln
Tyr Gln Leu 50 55 60Gln Ala Leu Ser Ser Gln Ile Asn Pro His Phe Leu
Tyr Asn Thr Leu65 70 75 80Asp Thr Ile Ile Trp Met Ala Glu Phe His
Asp Ser Gln Arg Val Val 85 90 95Gln Val Thr Lys Ser Leu Ala Thr Tyr
Phe Arg Leu Ala Leu Asn Gln 100 105 110Gly Lys Asp Leu Ile Cys Leu
Ser Asp Glu Ile Asn His Val Arg Gln 115 120 125Tyr Leu Phe Ile Gln
Lys Gln Arg Tyr Gly Asp Lys Leu Glu Tyr Glu 130 135 140Ile Asn Glu
Asn Val Ala Phe Asp Asn Leu Val Leu Pro Lys Leu Val145 150 155
160Leu Gln Pro Leu Val Glu Asn Ala Leu Tyr His Gly Ile Lys Glu Lys
165 170 175Glu Gly Gln Gly His Ile Lys Leu Ser Val Gln Lys Gln Asp
Ser Gly 180 185 190Leu Val Ile Arg Ile Glu Asp Asp Gly Val Gly Phe
Gln Asp Ala Gly 195 200 205Asp Ser Ser Gln Ser Gln Leu Lys Arg Gly
Gly Val Gly Leu Gln Asn 210 215 220Val Asp Gln Arg Leu Lys Leu His
Phe Gly Ala Asn Tyr His Met Lys225 230 235 240Ile Asp Ser Arg Pro
Gln Lys Gly Thr Lys Val Glu Ile Tyr Ile Asn 245 250 255Arg Ile Glu
Thr Ser 260165325DNAStreptococcus pneumoniae 165taggtcatat
gggacttttt ttctacaaca aaataggctc cataatatct ataagggatt 60tacccactac
aaatattata gagccgaaaa ttcacatcta atatatgcag actactttga
120aatgaaatta aaaaaattat taaaggatga cacaaaagtt tttgaaaaat
ctacattcaa 180atttgtagaa ggatataaaa tatacctgac agaatctaaa
gaatctggaa ttaaacaaat 240ggacaatgtc ataaaatatt ttgagtttat
tgaatctaaa agtattgctt tatattttca 300aaaacgatta aatgagctga tagat
325166108PRTStreptococcus pneumoniae 166Arg Ser Tyr Gly Thr Phe Phe
Leu Gln Gln Asn Arg Leu His Asn Ile1 5 10 15Tyr Lys Gly Phe Thr His
Tyr Lys Tyr Tyr Arg Ala Glu Asn Ser His 20 25 30Leu Ile Tyr Ala Asp
Tyr Phe Glu Met Lys Leu Lys Lys Leu Leu Lys 35 40 45Asp Asp Thr Lys
Val Phe Glu Lys Ser Thr Phe Lys Phe Val Glu Gly 50 55 60Tyr Lys Ile
Tyr Leu Thr Glu Ser Lys Glu Ser Gly Ile Lys Gln Met65 70 75 80Asp
Asn Val Ile Lys Tyr Phe Glu Phe Ile Glu Ser Lys Ser Ile Ala 85 90
95Leu Tyr Phe Gln Lys Arg Leu Asn Glu Leu Ile Asp 100
105167238DNAStreptococcus pneumoniae 167caacgttgag aattatttgc
gaatgtgttt ggatagcatt cagaatcaga cgtatcaaaa 60ttttgagtgt ttattaatca
atgatggctc tccagatcat tcatccaaaa tatgtgaaga 120atttgtagag
aaagattctc gtttcaaata ttttgagaaa gcaaacggcg gtctttcatc
180agctcgtaac ctaggtattg aatgttcggg ggggggcgta cattactttt gtagactc
23816879PRTStreptococcus pneumoniae 168Asn Val Glu Asn Tyr Leu Arg
Met Cys Leu Asp Ser Ile Gln Asn Gln1 5 10 15Thr Tyr Gln Asn Phe Glu
Cys Leu Leu Ile Asn Asp Gly Ser Pro Asp 20 25 30His Ser Ser Lys Ile
Cys Glu Glu Phe Val Glu Lys Asp Ser Arg Phe 35 40 45Lys Tyr Phe Glu
Lys Ala Asn Gly Gly Leu Ser Ser Ala Arg Asn Leu 50 55 60Gly Ile Glu
Cys Ser Gly Gly Gly Val His Tyr Phe Cys Arg Leu65 70
75169742DNAStreptococcus pneumoniae 169ctactatcaa tcaagttctt
cagccattga ggccaccatt gagggcaaca gccaaacgac 60catcagccag actagccact
ttattcagtc ttatatcaaa aaactagaaa ccacctcgac 120tggtttgacc
cagcagacgg atgttctggc ctatgctgag aatcccagtc aagacaaggt
180cgagggaatc cgagatttgt ttttgaccat cttgaagtca gataaggact
tgaaaactgt 240tgtgctggtg accaaatctg gtcaggtcat ttctacagat
gacagtgtgc agatgaaaac 300ttcctctgat atgatggctg aggattggta
ccaaaaggcc attcatcagg gagctatgcc 360tgttttgact ccagctcgta
aatcagatag tcagtgggtc atttctgtca ctcaagaact 420tgttgatgca
aagggagcca atcttggtgt gcttcgtttg gatatttctt atgaaactct
480ggaagcctat ctcaatcaac tccagttggg gcagcagggc tttgccttca
ttatcaatga 540aaaccatgaa tttgtctacc atcctcaaca cacagtttat
agttcgtcta gcaaaatgga 600ggctatgaaa ccctacatcg atacaggtca
gggttatact cctggtcaca aatcctacgt 660cagtcaagag aagattgcag
gaactgattg gacggtgctt ggcgtgtcat cattggaaaa 720gttagaccag
gttcggagtc ag 742170247PRTStreptococcus pneumoniae 170Tyr Tyr Gln
Ser Ser Ser Ser Ala Ile Glu Ala Thr Ile Glu Gly Asn1 5 10 15Ser Gln
Thr Thr Ile Ser Gln Thr Ser His Phe Ile Gln Ser Tyr Ile 20 25 30Lys
Lys Leu Glu Thr Thr Ser Thr Gly Leu Thr Gln Gln Thr Asp Val 35 40
45Leu Ala Tyr Ala Glu Asn Pro Ser Gln Asp Lys Val Glu Gly Ile Arg
50 55 60Asp Leu Phe Leu Thr Ile Leu Lys Ser Asp Lys Asp Leu Lys Thr
Val65 70 75 80Val Leu Val Thr Lys Ser Gly Gln Val Ile Ser Thr Asp
Asp Ser Val 85 90 95Gln Met Lys Thr Ser Ser Asp Met Met Ala Glu Asp
Trp Tyr Gln Lys 100 105 110Ala Ile His Gln Gly Ala Met Pro Val Leu
Thr Pro Ala Arg Lys Ser 115 120 125Asp Ser Gln Trp Val Ile Ser Val
Thr Gln Glu Leu Val Asp Ala Lys 130 135 140Gly Ala Asn Leu Gly Val
Leu Arg Leu Asp Ile Ser Tyr Glu Thr Leu145 150 155 160Glu Ala Tyr
Leu Asn Gln Leu Gln Leu Gly Gln Gln Gly Phe Ala Phe 165 170 175Ile
Ile Asn Glu Asn His Glu Phe Val Tyr His Pro Gln His Thr Val 180 185
190Tyr Ser Ser Ser Ser Lys Met Glu Ala Met Lys Pro Tyr Ile Asp Thr
195 200 205Gly Gln Gly Tyr Thr Pro Gly His Lys Ser Tyr Val Ser Gln
Glu Lys 210 215 220Ile Ala Gly Thr Asp Trp Thr Val Leu Gly Val Ser
Ser Leu Glu Lys225 230 235 240Leu Asp Gln Val Arg Ser Gln
2451711282DNAStreptococcus pneumoniaemisc_feature(712)..(712)n is
a, c, g, or t 171gacaaaaaca ttaaaacgtc ctgaggtttt atcacctgca
gggactttag agaagctaaa 60ggtagctgtt cagtatggag cagatgctgt ctttatcggt
ggtcaggcct atggtcttcg 120tagccgtgcg ggaaacttta ctttcgaaca
gatggaagaa ggcgtgcagt ttgcggccaa 180gtatggtgcc aaggtctatg
tagcggctaa tatggttatg cacgaaggaa atgaagctgg 240tgctggtgag
tggttccgta aactgcgtga tatcgggatt gcagcagtta tcgtatctga
300cccagccttg attatgattg cagtgactga agcaccaggc cttgaaatcc
acctttctac 360ccaagccagt gccactaact atgaaaccct tgagttctgg
aaagagctag gcttgactcg 420tgtcgtttta gcgcgtgagg tttcaatgga
agaattagct gagatccgca aacgtacaga 480tgttgaaatt gaagcctttg
tccatggagc tatgtgtatt tcatactctg gacgttgtac 540tctttcaaac
cacatgagta tgcgtgatgc caaccgtggt ggatgttctc agtcatgccg
600ttggaaatac gacctttacg atatgccatt tgggaaagaa cgtaagagtt
tgcagggtga 660gattccagaa gaattttcaa tgtcagccgt tgacatgtct
atgattgacc anattccaga 720tatgattgaa aatggtgtgg acagtctaaa
aatcgaagga cgtatgnagt ctattcacta 780ngtatcaaca gtaaccaact
gctacaaggc ggctgtggat gcctatcttg aaagtcctga 840aaagtttgaa
gctatcaaac aagacttggt ggacgagatg tggaaggttg cccaacgtga
900actggctaca ggattttact atggtacacc atctgaaaat gagcagttgt
ttggtgctcg 960tcgtaaaatc cctgagtaca agtttgtcgc tgaagtggtt
tcttatgatg atgcggcaca 1020aacagcaact attcgtcaac gaaacgtcat
taacgaaggg gaccaagttg agttttatgg 1080tccaggtttc cgtcattttg
aaacctatat tgaagatttg catgatgcta aaggcaataa 1140aatcgaccgc
gctccaaatc caatggaact attgactatt aaagtcccac aacctgttca
1200atcaggagac atggttcgag ctcttaaaga ggggcttatc aatctttata
aggaagatgg 1260aaccagcgtc acagttcgtg ct 1282172427PRTStreptococcus
pneumoniaeSITE(237)..(237)Xaa can be any naturally occurring amino
acid 172Thr Lys Thr Leu Lys Arg Pro Glu Val Leu Ser Pro Ala Gly Thr
Leu1 5 10 15Glu Lys Leu Lys Val Ala Val Gln Tyr Gly Ala Asp Ala Val
Phe Ile 20 25 30Gly Gly Gln Ala Tyr Gly Leu Arg Ser Arg Ala Gly Asn
Phe Thr Phe 35 40 45Glu Gln Met Glu Glu Gly Val Gln Phe Ala Ala Lys
Tyr Gly Ala Lys 50 55 60Val Tyr Val Ala Ala Asn Met Val Met His Glu
Gly Asn Glu Ala Gly65 70 75 80Ala Gly Glu Trp Phe Arg Lys Leu Arg
Asp Ile Gly Ile Ala Ala Val 85 90 95Ile Val Ser Asp Pro Ala Leu Ile
Met Ile Ala Val Thr Glu Ala Pro 100 105 110Gly Leu Glu Ile His Leu
Ser Thr Gln Ala Ser Ala Thr Asn Tyr Glu 115 120 125Thr Leu Glu Phe
Trp Lys Glu Leu Gly Leu Thr Arg Val Val Leu Ala 130 135 140Arg Glu
Val Ser Met Glu Glu Leu Ala Glu Ile Arg Lys Arg Thr Asp145 150 155
160Val Glu Ile Glu Ala Phe Val His Gly Ala Met Cys Ile Ser Tyr Ser
165 170 175Gly Arg Cys Thr Leu Ser Asn His Met Ser Met Arg Asp Ala
Asn Arg 180 185 190Gly Gly Cys Ser Gln Ser Cys Arg Trp Lys Tyr Asp
Leu Tyr Asp Met 195 200 205Pro Phe Gly Lys Glu Arg Lys Ser Leu Gln
Gly Glu Ile Pro Glu Glu 210 215 220Phe Ser Met Ser Ala Val Asp Met
Ser Met Ile Asp Xaa Ile Pro Asp225 230 235 240Met Ile Glu Asn Gly
Val Asp Ser Leu Lys Ile Glu Gly Arg Met Xaa 245 250 255Ser Ile His
Xaa Val Ser Thr Val Thr Asn Cys Tyr Lys Ala Ala Val 260 265 270Asp
Ala Tyr Leu Glu Ser Pro Glu Lys Phe Glu Ala Ile Lys Gln Asp 275 280
285Leu Val Asp Glu Met Trp Lys Val Ala Gln Arg Glu Leu Ala Thr Gly
290 295 300Phe Tyr Tyr Gly Thr Pro Ser Glu Asn Glu Gln Leu Phe Gly
Ala Arg305 310 315 320Arg Lys Ile Pro Glu Tyr Lys Phe Val Ala Glu
Val Val Ser Tyr Asp 325 330 335Asp Ala Ala Gln Thr Ala Thr Ile Arg
Gln Arg Asn Val Ile Asn Glu 340 345 350Gly Asp Gln Val Glu Phe Tyr
Gly Pro Gly Phe Arg His Phe Glu Thr 355 360 365Tyr Ile Glu Asp Leu
His Asp Ala Lys Gly Asn Lys Ile Asp Arg Ala 370 375 380Pro Asn Pro
Met Glu Leu Leu Thr Ile Lys Val Pro Gln Pro Val Gln385 390 395
400Ser Gly Asp Met Val Arg Ala Leu Lys Glu Gly Leu Ile Asn Leu Tyr
405 410 415Lys Glu Asp Gly Thr Ser Val Thr Val Arg Ala 420
425173778DNAStreptococcus pneumoniae 173ttctcaggag acctttaaaa
atatcaccaa tagcttctcc atgcaaatca atcgtcgcgt 60caaccaagga acgcctcgtg
gtgctgggaa tatcaagggt gaagacatca aaaaaatcac 120cgaaaacaag
gccattgagt cttatgtcaa acgtatcaac gctatcggag atttgactgg
180atatgacctg attgaaacgc cagaaaccaa gaagaatctc actgctgatc
gtgccaagcg 240ttttggaagt agcttgatga ttacaggtgt caatgactcc
tctaaagaag acaagtttgt 300ctctggttct tataaactag tcgaaggaga
gcacttaacc aacgacgaca aggataaaat 360cctcttgcac aaggacttgg
cagccaaaca cggctggaaa gtaggggaca aggttaaact 420ggactctaat
atctacgatg cagataatga aaaaggagcc aaggaaacag ttgaagtgac
480aatcaaggga ctctttgatg gtcataataa gtcagcagta acctactcac
aagaacttta 540cgaaaacaca gctattacag acattcacac tgctgcaaaa
ctttatggat acacagaaga 600cacagccatt tatggggacg caaccttctt
tgtaacagca gacaagaact tggatgatgt 660tatgaaagag ttgaatggca
tcagtggtat caactggaag agctacacac tcgtcaagag 720ctcctctaac
tacccagctc ttgagcaatc tatctctggt atgtacaaga tggccaac
778174259PRTStreptococcus pneumoniae 174Ser Gln Glu Thr Phe Lys Asn
Ile Thr Asn Ser Phe Ser Met Gln Ile1 5 10 15Asn Arg Arg Val Asn Gln
Gly Thr Pro Arg Gly Ala Gly Asn Ile Lys 20 25 30Gly Glu Asp Ile Lys
Lys Ile Thr Glu Asn Lys Ala Ile Glu Ser Tyr 35 40 45Val Lys Arg Ile
Asn Ala Ile Gly Asp Leu Thr Gly Tyr Asp Leu Ile 50 55 60Glu Thr Pro
Glu Thr Lys Lys Asn Leu Thr Ala Asp Arg Ala Lys Arg65 70 75 80Phe
Gly Ser Ser Leu Met Ile Thr Gly Val Asn Asp Ser Ser Lys Glu 85 90
95Asp Lys Phe Val Ser Gly Ser Tyr Lys Leu Val Glu Gly Glu His Leu
100 105 110Thr Asn Asp Asp Lys Asp Lys Ile Leu Leu His Lys Asp Leu
Ala Ala 115 120 125Lys His Gly Trp Lys Val Gly Asp Lys Val Lys Leu
Asp Ser Asn Ile 130 135 140Tyr Asp Ala Asp Asn Glu Lys Gly Ala Lys
Glu Thr Val Glu Val Thr145 150 155 160Ile Lys Gly Leu Phe Asp Gly
His Asn Lys Ser Ala Val Thr Tyr Ser 165 170 175Gln Glu Leu Tyr Glu
Asn Thr Ala Ile Thr Asp Ile His Thr Ala Ala 180
185 190Lys Leu Tyr Gly Tyr Thr Glu Asp Thr Ala Ile Tyr Gly Asp Ala
Thr 195 200 205Phe Phe Val Thr Ala Asp Lys Asn Leu Asp Asp Val Met
Lys Glu Leu 210 215 220Asn Gly Ile Ser Gly Ile Asn Trp Lys Ser Tyr
Thr Leu Val Lys Ser225 230 235 240Ser Ser Asn Tyr Pro Ala Leu Glu
Gln Ser Ile Ser Gly Met Tyr Lys 245 250 255Met Ala
Asn175694DNAStreptococcus pneumoniaemisc_feature(591)..(591)n is a,
c, g, or t 175agtaaatgcg caatcaaatt cattaatatt aatagatgaa
cctgaaatct cacttcatcc 60gagtgcaatc tataaattta aagagttttt acttcaagag
tgtttaaata aaaaacatca 120aattattatc actacacatt ctacacaact
tataaaagat tttcctagag aagccgtgaa 180acttttagtg aaaaacggag
aaaaggtaga tgttattgaa aatattgatt atcaggatgc 240attttttgaa
ttaggtgatg tgtatcattc taggaagatg atttatgttg aagatagact
300agctaaatat attctagagt ttgttatcac tcattcaggt agtgagaatc
ttaaacagaa 360tttagtagtg agatatattc ctggtggagc aaatcaaata
atttgtaata atattttaaa 420ctcatcgtat ttagattccg ataaccatta
tttttggctt gatggagatc aaaacactaa 480tgttagtgaa tcaaataatt
taatgaacta tcttgaaaat ggtgttgtta tatcagataa 540aattcctgaa
tcagataata aaaatcttga tgatattata aaattgataa ngggatgtcc
600aattaaattt aatgtttcag gtaataaagg gcaaaaaaat aatattgaat
taattgcgaa 660acaaagaagc tttatagatt attgggctaa atac
694176231PRTStreptococcus pneumoniaeSITE(197)..(197)Xaa can be any
naturally occurring amino acid 176Val Asn Ala Gln Ser Asn Ser Leu
Ile Leu Ile Asp Glu Pro Glu Ile1 5 10 15Ser Leu His Pro Ser Ala Ile
Tyr Lys Phe Lys Glu Phe Leu Leu Gln 20 25 30Glu Cys Leu Asn Lys Lys
His Gln Ile Ile Ile Thr Thr His Ser Thr 35 40 45Gln Leu Ile Lys Asp
Phe Pro Arg Glu Ala Val Lys Leu Leu Val Lys 50 55 60Asn Gly Glu Lys
Val Asp Val Ile Glu Asn Ile Asp Tyr Gln Asp Ala65 70 75 80Phe Phe
Glu Leu Gly Asp Val Tyr His Ser Arg Lys Met Ile Tyr Val 85 90 95Glu
Asp Arg Leu Ala Lys Tyr Ile Leu Glu Phe Val Ile Thr His Ser 100 105
110Gly Ser Glu Asn Leu Lys Gln Asn Leu Val Val Arg Tyr Ile Pro Gly
115 120 125Gly Ala Asn Gln Ile Ile Cys Asn Asn Ile Leu Asn Ser Ser
Tyr Leu 130 135 140Asp Ser Asp Asn His Tyr Phe Trp Leu Asp Gly Asp
Gln Asn Thr Asn145 150 155 160Val Ser Glu Ser Asn Asn Leu Met Asn
Tyr Leu Glu Asn Gly Val Val 165 170 175Ile Ser Asp Lys Ile Pro Glu
Ser Asp Asn Lys Asn Leu Asp Asp Ile 180 185 190Ile Lys Leu Ile Xaa
Gly Cys Pro Ile Lys Phe Asn Val Ser Gly Asn 195 200 205Lys Gly Gln
Lys Asn Asn Ile Glu Leu Ile Ala Lys Gln Arg Ser Phe 210 215 220Ile
Asp Tyr Trp Ala Lys Tyr225 230177550DNAStreptococcus pneumoniae
177ttaccgcgtt catcaagatg tcaaacaagt catgacctat caacccatgg
tgcgagaaat 60attgagtgaa caagacaccc cagcaaacga agagcttgtg cttgctatga
tttatactga 120aacaaaagga aaagaaggcg atgttatgca gtctagtgag
tctgcaagtg gttccaccaa 180caccatcaat gataatgcct ctagcattcg
gcaaggcatt caaactctga caggcaatct 240ctatctggcg cagaagaagg
gggtagatat ctggacagct gttcaagcct ataattttgg 300acctgcctat
atcgatttta tcgcccaaaa tggcaaggaa aataccctgg ctctagccaa
360acagtactct cgtgagactg ttgccccctt gcttggtaat aggactggaa
agacttatag 420ttatattcac cccatttcca tttttcacgg tgctgaactc
tatgtaaatg gaggaaacta 480ttattattct agacaggtac gacttaacct
ttacatcatc aaatgtttca ctctcttttc 540aacatctggc
550178183PRTStreptococcus pneumoniae 178Tyr Arg Val His Gln Asp Val
Lys Gln Val Met Thr Tyr Gln Pro Met1 5 10 15Val Arg Glu Ile Leu Ser
Glu Gln Asp Thr Pro Ala Asn Glu Glu Leu 20 25 30Val Leu Ala Met Ile
Tyr Thr Glu Thr Lys Gly Lys Glu Gly Asp Val 35 40 45Met Gln Ser Ser
Glu Ser Ala Ser Gly Ser Thr Asn Thr Ile Asn Asp 50 55 60Asn Ala Ser
Ser Ile Arg Gln Gly Ile Gln Thr Leu Thr Gly Asn Leu65 70 75 80Tyr
Leu Ala Gln Lys Lys Gly Val Asp Ile Trp Thr Ala Val Gln Ala 85 90
95Tyr Asn Phe Gly Pro Ala Tyr Ile Asp Phe Ile Ala Gln Asn Gly Lys
100 105 110Glu Asn Thr Leu Ala Leu Ala Lys Gln Tyr Ser Arg Glu Thr
Val Ala 115 120 125Pro Leu Leu Gly Asn Arg Thr Gly Lys Thr Tyr Ser
Tyr Ile His Pro 130 135 140Ile Ser Ile Phe His Gly Ala Glu Leu Tyr
Val Asn Gly Gly Asn Tyr145 150 155 160Tyr Tyr Ser Arg Gln Val Arg
Leu Asn Leu Tyr Ile Ile Lys Cys Phe 165 170 175Thr Leu Phe Ser Thr
Ser Gly 180179334DNAStreptococcus pneumoniae 179gtggatgggc
tttaactatc ttcgtattcg ccgtgcggct aaaattgtgg acaatgagga 60gtttgaagcc
ttgattcgta cgggtcaatt gattgatttg cgcgacccag cagaattcca
120cagaaaacat atccttggtg cacgcaatat tccttcaagt cagttgaaaa
ctagtcttgc 180agcccttcgt aaagataaac ctgtccttct ctacgaaaac
caacgtgcgc aacgagttac 240aaatgcagct ctttacttga aaaaacaagg
tttttctgag atttatatcc tttcttatgg 300cttggattct tggaaaggga
aagtgaagac tagc 334180111PRTStreptococcus pneumoniae 180Trp Met Gly
Phe Asn Tyr Leu Arg Ile Arg Arg Ala Ala Lys Ile Val1 5 10 15Asp Asn
Glu Glu Phe Glu Ala Leu Ile Arg Thr Gly Gln Leu Ile Asp 20 25 30Leu
Arg Asp Pro Ala Glu Phe His Arg Lys His Ile Leu Gly Ala Arg 35 40
45Asn Ile Pro Ser Ser Gln Leu Lys Thr Ser Leu Ala Ala Leu Arg Lys
50 55 60Asp Lys Pro Val Leu Leu Tyr Glu Asn Gln Arg Ala Gln Arg Val
Thr65 70 75 80Asn Ala Ala Leu Tyr Leu Lys Lys Gln Gly Phe Ser Glu
Ile Tyr Ile 85 90 95Leu Ser Tyr Gly Leu Asp Ser Trp Lys Gly Lys Val
Lys Thr Ser 100 105 1101811342DNAStreptococcus pneumoniae
181actaaaccag catcgttcgc aggaaaataa ggacaataat cgtgtctctt
atgtggatgg 60cagccagtca agtcagaaaa gtgaaaactt gacaccagac caggttagcc
agaaagaagg 120aattcaggct gagcaaattg taatcaaaat tacagatcag
ggctatgtaa cgtcacacgg 180tgaccactat cattactata atgggaaagt
tccttatgat gccctcttta gtgaagaact 240cttgatgaag gatccaaact
atcaacttaa agacgctgat attgtcaatg aagtcaaggg 300tggttatatc
atcaaggtcg atggaaaata ttatgtctac ctgaaagatg cagctcatgc
360tgataatgtt cgaactaaag atgaaatcaa tcgtcaaaaa caagaacatg
tcaaagataa 420tgagaaggtt aactctaatg ttgctgtagc aaggtctcag
ggacgatata cgacaaatga 480tggttatgtc tttaatccag ctgatattat
cgaagatacg ggtaatgctt atatcgttcc 540tcatggaggt cactatcact
acattcccaa aagcgattta tctgctagtg aattagcagc 600agctaaagca
catctggctg gaaaaaatat gcaaccgagt cagttaagct attcttcaac
660agctagtgac aataacacgc aatctgtagc aaaaggatca actagcaagc
cagcaaataa 720atctgaaaat ctccagagtc ttttgaagga actctatgat
tcacctagcg cccaacgtta 780cagtgaatca gatggcctgg tctttgaccc
tgctaagatt atcagtcgta caccaaatgg 840agttgcgatt ccgcatggcg
accattacca ctttattcct tacagcaagc tttctgcctt 900agaagaaaag
attgccagaa tggtgcctat cagtggaact ggttctacag tttctacaaa
960tgcaaaacct aatgaagtag tgtctagtct aggcagtctt tcaagcaatc
cttcttcttt 1020aacgacaagt aaggagctct cttcagcatc tgatggttat
atttttaatc caaaagatat 1080cgttgaagaa acggctacag cttatattgt
aagacatggt gatcatttcc attacattcc 1140aaaatcaaat caaattgggc
aaccgactct tccaaacaat agtctagcaa caccttctcc 1200atctcttcca
atcaatccag gaacttcaca tgagaaacat gaagaagatg gatacggatt
1260tgatgctaat cgtattatcg ctgaagatga atcaggtttt gtcatgagtc
acggagacca 1320caatcattat ttcttcaaga ag 1342182447PRTStreptococcus
pneumoniae 182Leu Asn Gln His Arg Ser Gln Glu Asn Lys Asp Asn Asn
Arg Val Ser1 5 10 15Tyr Val Asp Gly Ser Gln Ser Ser Gln Lys Ser Glu
Asn Leu Thr Pro 20 25 30Asp Gln Val Ser Gln Lys Glu Gly Ile Gln Ala
Glu Gln Ile Val Ile 35 40 45Lys Ile Thr Asp Gln Gly Tyr Val Thr Ser
His Gly Asp His Tyr His 50 55 60Tyr Tyr Asn Gly Lys Val Pro Tyr Asp
Ala Leu Phe Ser Glu Glu Leu65 70 75 80Leu Met Lys Asp Pro Asn Tyr
Gln Leu Lys Asp Ala Asp Ile Val Asn 85 90 95Glu Val Lys Gly Gly Tyr
Ile Ile Lys Val Asp Gly Lys Tyr Tyr Val 100 105 110Tyr Leu Lys Asp
Ala Ala His Ala Asp Asn Val Arg Thr Lys Asp Glu 115 120 125Ile Asn
Arg Gln Lys Gln Glu His Val Lys Asp Asn Glu Lys Val Asn 130 135
140Ser Asn Val Ala Val Ala Arg Ser Gln Gly Arg Tyr Thr Thr Asn
Asp145 150 155 160Gly Tyr Val Phe Asn Pro Ala Asp Ile Ile Glu Asp
Thr Gly Asn Ala 165 170 175Tyr Ile Val Pro His Gly Gly His Tyr His
Tyr Ile Pro Lys Ser Asp 180 185 190Leu Ser Ala Ser Glu Leu Ala Ala
Ala Lys Ala His Leu Ala Gly Lys 195 200 205Asn Met Gln Pro Ser Gln
Leu Ser Tyr Ser Ser Thr Ala Ser Asp Asn 210 215 220Asn Thr Gln Ser
Val Ala Lys Gly Ser Thr Ser Lys Pro Ala Asn Lys225 230 235 240Ser
Glu Asn Leu Gln Ser Leu Leu Lys Glu Leu Tyr Asp Ser Pro Ser 245 250
255Ala Gln Arg Tyr Ser Glu Ser Asp Gly Leu Val Phe Asp Pro Ala Lys
260 265 270Ile Ile Ser Arg Thr Pro Asn Gly Val Ala Ile Pro His Gly
Asp His 275 280 285Tyr His Phe Ile Pro Tyr Ser Lys Leu Ser Ala Leu
Glu Glu Lys Ile 290 295 300Ala Arg Met Val Pro Ile Ser Gly Thr Gly
Ser Thr Val Ser Thr Asn305 310 315 320Ala Lys Pro Asn Glu Val Val
Ser Ser Leu Gly Ser Leu Ser Ser Asn 325 330 335Pro Ser Ser Leu Thr
Thr Ser Lys Glu Leu Ser Ser Ala Ser Asp Gly 340 345 350Tyr Ile Phe
Asn Pro Lys Asp Ile Val Glu Glu Thr Ala Thr Ala Tyr 355 360 365Ile
Val Arg His Gly Asp His Phe His Tyr Ile Pro Lys Ser Asn Gln 370 375
380Ile Gly Gln Pro Thr Leu Pro Asn Asn Ser Leu Ala Thr Pro Ser
Pro385 390 395 400Ser Leu Pro Ile Asn Pro Gly Thr Ser His Glu Lys
His Glu Glu Asp 405 410 415Gly Tyr Gly Phe Asp Ala Asn Arg Ile Ile
Ala Glu Asp Glu Ser Gly 420 425 430Phe Val Met Ser His Gly Asp His
Asn His Tyr Phe Phe Lys Lys 435 440 445183934DNAStreptococcus
pneumoniae 183tgactacctt gaaatcccac tttacagcta tcttggtgga
ttcaacacta aagttcttcc 60aactccaatg atgaacatca tcaacggtgg ttctcactct
gacgctccaa tcgctttcca 120agagttcatg atcttgccag ttggtgcgcc
aacatttaaa gaagcccttc gttacggtgc 180tgaaatcttc cacgctctta
agaaaatcct taaatcacgt ggtttggaaa ctgccgtagg 240tgacgaaggt
ggattcgctc ctcgtttcga aggaactgaa gatggtgttg aaactatcct
300tgctgcgatt gaagctgctg gatatgtacc aggtaaagac gtatttatcg
gatttgactg 360tgcttcatca gaattctacg ataaagaacg taaagtttac
gactacacta aatttgaagg 420tgaaggtgct gctgttcgta catctgcaga
acaaatcgac taccttgaag aattggttaa 480caaataccca atcatcacta
ttgaagatgg tatggatgaa aacgactggg atggttggaa 540agctcttact
gaacgtcttg gtaagaaagt acaacttgtt ggtgacgact tcttcgtaac
600aaacactgac taccttgcac gtggtatcca agaaggtgct gctaactcaa
tccttatcaa 660agttaaccaa atcggtactc ttactgaaac ttttgaagct
atcgaaatgg ctaaagaagc 720tggttacact gctgttgtat cacaccgttc
aggtgaaact gaagattcaa caatcgctga 780tattgcagtt gcaactaacg
caggacaaat caagactggt tcactttcac gtacagaccg 840catcgctaaa
tacaaccaat tgcttcgtat cgaagaccaa cttggtgaag tagctgaata
900tcgtggattg aaatcattct acaaccttaa aaaa 934184311PRTStreptococcus
pneumoniae 184Asp Tyr Leu Glu Ile Pro Leu Tyr Ser Tyr Leu Gly Gly
Phe Asn Thr1 5 10 15Lys Val Leu Pro Thr Pro Met Met Asn Ile Ile Asn
Gly Gly Ser His 20 25 30Ser Asp Ala Pro Ile Ala Phe Gln Glu Phe Met
Ile Leu Pro Val Gly 35 40 45Ala Pro Thr Phe Lys Glu Ala Leu Arg Tyr
Gly Ala Glu Ile Phe His 50 55 60Ala Leu Lys Lys Ile Leu Lys Ser Arg
Gly Leu Glu Thr Ala Val Gly65 70 75 80Asp Glu Gly Gly Phe Ala Pro
Arg Phe Glu Gly Thr Glu Asp Gly Val 85 90 95Glu Thr Ile Leu Ala Ala
Ile Glu Ala Ala Gly Tyr Val Pro Gly Lys 100 105 110Asp Val Phe Ile
Gly Phe Asp Cys Ala Ser Ser Glu Phe Tyr Asp Lys 115 120 125Glu Arg
Lys Val Tyr Asp Tyr Thr Lys Phe Glu Gly Glu Gly Ala Ala 130 135
140Val Arg Thr Ser Ala Glu Gln Ile Asp Tyr Leu Glu Glu Leu Val
Asn145 150 155 160Lys Tyr Pro Ile Ile Thr Ile Glu Asp Gly Met Asp
Glu Asn Asp Trp 165 170 175Asp Gly Trp Lys Ala Leu Thr Glu Arg Leu
Gly Lys Lys Val Gln Leu 180 185 190Val Gly Asp Asp Phe Phe Val Thr
Asn Thr Asp Tyr Leu Ala Arg Gly 195 200 205Ile Gln Glu Gly Ala Ala
Asn Ser Ile Leu Ile Lys Val Asn Gln Ile 210 215 220Gly Thr Leu Thr
Glu Thr Phe Glu Ala Ile Glu Met Ala Lys Glu Ala225 230 235 240Gly
Tyr Thr Ala Val Val Ser His Arg Ser Gly Glu Thr Glu Asp Ser 245 250
255Thr Ile Ala Asp Ile Ala Val Ala Thr Asn Ala Gly Gln Ile Lys Thr
260 265 270Gly Ser Leu Ser Arg Thr Asp Arg Ile Ala Lys Tyr Asn Gln
Leu Leu 275 280 285Arg Ile Glu Asp Gln Leu Gly Glu Val Ala Glu Tyr
Arg Gly Leu Lys 290 295 300Ser Phe Tyr Asn Leu Lys Lys305
310185541DNAStreptococcus pneumoniae 185tcgtatcttt ttttggagca
atgttcgcgt agaaggacat tccatggatc cgaccctagc 60ggatggcgaa attctcttcg
ttgtaaaaca ccttcctatt gaccgttttg atatcgtggt 120ggcccatgag
gaagatggca ataaggacat cgtcaagcgc gtgattggaa tgcctggcga
180caccattcgt tacgaaaatg ataaactcta catcaatgac aaagaaacgg
acgagcctta 240tctagcagac tatatcaaac gcttcaagga tgacaaactc
caaagcactt actcaggcaa 300gggctttgaa ggaaataaag gaactttctt
tagaagtatc gctcaaaaag ctcaagcctt 360cacagttgat gtcaactaca
acaccaactt tagctttact gttccagaag gagaatacct 420tctcctcgga
gatgaccgct tggtttcgag cgacagccgc cacgtaggta ccttcaaagc
480aaaagatatc acaggggaag ctaaattccg cttatggcca atcacccgta
tcggaacatt 540t 541186180PRTStreptococcus pneumoniae 186Arg Ile Phe
Phe Trp Ser Asn Val Arg Val Glu Gly His Ser Met Asp1 5 10 15Pro Thr
Leu Ala Asp Gly Glu Ile Leu Phe Val Val Lys His Leu Pro 20 25 30Ile
Asp Arg Phe Asp Ile Val Val Ala His Glu Glu Asp Gly Asn Lys 35 40
45Asp Ile Val Lys Arg Val Ile Gly Met Pro Gly Asp Thr Ile Arg Tyr
50 55 60Glu Asn Asp Lys Leu Tyr Ile Asn Asp Lys Glu Thr Asp Glu Pro
Tyr65 70 75 80Leu Ala Asp Tyr Ile Lys Arg Phe Lys Asp Asp Lys Leu
Gln Ser Thr 85 90 95Tyr Ser Gly Lys Gly Phe Glu Gly Asn Lys Gly Thr
Phe Phe Arg Ser 100 105 110Ile Ala Gln Lys Ala Gln Ala Phe Thr Val
Asp Val Asn Tyr Asn Thr 115 120 125Asn Phe Ser Phe Thr Val Pro Glu
Gly Glu Tyr Leu Leu Leu Gly Asp 130 135 140Asp Arg Leu Val Ser Ser
Asp Ser Arg His Val Gly Thr Phe Lys Ala145 150 155 160Lys Asp Ile
Thr Gly Glu Ala Lys Phe Arg Leu Trp Pro Ile Thr Arg 165 170 175Ile
Gly Thr Phe 180187400DNAStreptococcus pneumoniae 187ggactctctc
aaagatgtga aagcaaatgc tagcgacagc aagcctgcac aggacaagaa 60ggatgcaaaa
caaggaacgg aagatagtaa ggattcagat aagatgactg aaacaaactc
120agttccggca ggagtgattg tggtcagtct acttgccctc ctaggcgtga
ttgccttctg 180gctgattcgc cgtaagaaag agtcagaaat ccagcaatta
agcacggaat tgatcaaggt 240tctaggacag ctagatgcag aaaaagcgga
taaaaaagtc cttgccaaag cccaaaacct 300tctccaagaa acccttgatt
tcgtgaaaga agaaaatggc tcagcagaga cagaaactaa 360actagtagag
gagcttaaag caatccttga caaactcaag 400188133PRTStreptococcus
pneumoniae 188Asp Ser Leu Lys Asp Val Lys Ala Asn Ala Ser Asp Ser
Lys Pro Ala1 5 10 15Gln Asp Lys Lys Asp Ala Lys Gln Gly Thr Glu Asp
Ser Lys Asp Ser 20
25 30Asp Lys Met Thr Glu Thr Asn Ser Val Pro Ala Gly Val Ile Val
Val 35 40 45Ser Leu Leu Ala Leu Leu Gly Val Ile Ala Phe Trp Leu Ile
Arg Arg 50 55 60Lys Lys Glu Ser Glu Ile Gln Gln Leu Ser Thr Glu Leu
Ile Lys Val65 70 75 80Leu Gly Gln Leu Asp Ala Glu Lys Ala Asp Lys
Lys Val Leu Ala Lys 85 90 95Ala Gln Asn Leu Leu Gln Glu Thr Leu Asp
Phe Val Lys Glu Glu Asn 100 105 110Gly Ser Ala Glu Thr Glu Thr Lys
Leu Val Glu Glu Leu Lys Ala Ile 115 120 125Leu Asp Lys Leu Lys
1301891201DNAStreptococcus pneumoniae 189caagaaatcc tatcatctct
tccagaagca aacagagacg aggggaattc agactcagtt 60gattgaagaa tcgcttagtc
agcagactat aatccagtcc ttcaatgctc aaacagaatt 120tatccaaaga
ttgcgtgagg ctcatgacaa ctactcaggc tattctcagt cagccatctt
180ttattcttca acggtcaatc cttcgactcg ctttgtaaat gcactcattt
atgccctttt 240agctggagta ggagcttatc gtatcatgat gggttcagcc
ttgaccgtcg gtcgtttagt 300gacttttttg aactatgttc agcaatacac
caagcccttt aacgatattt cttcagtgct 360agctgagttg caaagtgctc
tggcttgcgt agagcgtatc tatggagtct tagatagccc 420tgaagtggct
gaaacaggta aggaagtctt gacgaccagt gaccaagtta agggagctat
480ttcctttaaa catgtctctt ttggctacca tcctgaaaaa attttgatta
aggacttgtc 540tatcgatatt ccagctggta gtaaggtagc catcgttggt
ccgacaggtg ctggaaaatc 600aactcttatc aatctcctta tgcgttttta
tcccattagc tcgggagata tcttgctgga 660tgggcaatcc atttatgatt
atacacgagt atcattgaga cagcagtttg gtatggtgct 720tcaagaaacc
tggctcacac aagggaccat tcatgataat attgcctttg gcaatcctga
780agccagtcga gagcaagtaa ttgctgctgc caaagcagct aatgcagact
ttttcatcca 840acagttgcca cagggatacg ataccaagtt ggaaaatgct
ggagaatctc tctctgtcgg 900ccaagctcag ctcttgacca tagcccgagt
ctttctggct attccaaaga ttcttatctt 960agacgaggca acttcttcca
ttgatacacg gacagaagtg ctggtacagg atgcctttgc 1020aaaactcatg
aagggccgca caagtttcat cattgctcac cgtttgtcaa ccattcagga
1080tgcggattta attcttgtct tagtagatgg tgatattgtt gaatatggta
accatcaaga 1140actcatggat agaaagggta agtattacca aatgcaaaaa
gctgcggctt ttagttctga 1200a 1201190400PRTStreptococcus pneumoniae
190Lys Lys Ser Tyr His Leu Phe Gln Lys Gln Thr Glu Thr Arg Gly Ile1
5 10 15Gln Thr Gln Leu Ile Glu Glu Ser Leu Ser Gln Gln Thr Ile Ile
Gln 20 25 30Ser Phe Asn Ala Gln Thr Glu Phe Ile Gln Arg Leu Arg Glu
Ala His 35 40 45Asp Asn Tyr Ser Gly Tyr Ser Gln Ser Ala Ile Phe Tyr
Ser Ser Thr 50 55 60Val Asn Pro Ser Thr Arg Phe Val Asn Ala Leu Ile
Tyr Ala Leu Leu65 70 75 80Ala Gly Val Gly Ala Tyr Arg Ile Met Met
Gly Ser Ala Leu Thr Val 85 90 95Gly Arg Leu Val Thr Phe Leu Asn Tyr
Val Gln Gln Tyr Thr Lys Pro 100 105 110Phe Asn Asp Ile Ser Ser Val
Leu Ala Glu Leu Gln Ser Ala Leu Ala 115 120 125Cys Val Glu Arg Ile
Tyr Gly Val Leu Asp Ser Pro Glu Val Ala Glu 130 135 140Thr Gly Lys
Glu Val Leu Thr Thr Ser Asp Gln Val Lys Gly Ala Ile145 150 155
160Ser Phe Lys His Val Ser Phe Gly Tyr His Pro Glu Lys Ile Leu Ile
165 170 175Lys Asp Leu Ser Ile Asp Ile Pro Ala Gly Ser Lys Val Ala
Ile Val 180 185 190Gly Pro Thr Gly Ala Gly Lys Ser Thr Leu Ile Asn
Leu Leu Met Arg 195 200 205Phe Tyr Pro Ile Ser Ser Gly Asp Ile Leu
Leu Asp Gly Gln Ser Ile 210 215 220Tyr Asp Tyr Thr Arg Val Ser Leu
Arg Gln Gln Phe Gly Met Val Leu225 230 235 240Gln Glu Thr Trp Leu
Thr Gln Gly Thr Ile His Asp Asn Ile Ala Phe 245 250 255Gly Asn Pro
Glu Ala Ser Arg Glu Gln Val Ile Ala Ala Ala Lys Ala 260 265 270Ala
Asn Ala Asp Phe Phe Ile Gln Gln Leu Pro Gln Gly Tyr Asp Thr 275 280
285Lys Leu Glu Asn Ala Gly Glu Ser Leu Ser Val Gly Gln Ala Gln Leu
290 295 300Leu Thr Ile Ala Arg Val Phe Leu Ala Ile Pro Lys Ile Leu
Ile Leu305 310 315 320Asp Glu Ala Thr Ser Ser Ile Asp Thr Arg Thr
Glu Val Leu Val Gln 325 330 335Asp Ala Phe Ala Lys Leu Met Lys Gly
Arg Thr Ser Phe Ile Ile Ala 340 345 350His Arg Leu Ser Thr Ile Gln
Asp Ala Asp Leu Ile Leu Val Leu Val 355 360 365Asp Gly Asp Ile Val
Glu Tyr Gly Asn His Gln Glu Leu Met Asp Arg 370 375 380Lys Gly Lys
Tyr Tyr Gln Met Gln Lys Ala Ala Ala Phe Ser Ser Glu385 390 395
4001911033DNAStreptococcus pneumoniae 191acgaaatgca gggcagacag
atgcctcgca aattgaaaag gcggcagtta gccaaggagg 60aaaagcagtg aaaaaaacag
aaattagtaa agacgcagac ttgcacgaaa tttatctagc 120tggaggttgt
ttctggggag tggaggaata tttctcacgt gttcccgggg tgacggatgc
180cgtttcaggc tatgcaaatg gtagaggaga aacaaccaag tacgaattga
ttaaccaaac 240aggtcatgca gaaaccgtcc atgtcaccta tgatgccaag
caaatttctc tcaaggaaat 300cctgcttcac tatttccgca ttatcaatcc
aaccagcaaa aataaacaag gaaatgatgt 360ggggacccag taccgtactg
gtgtttatta cacagatgac aaggatttgg aagtgattaa 420ccaagtcttt
gatgaggtgg ctaagaaata cgatcaacct ctagcagttg aaaaggaaaa
480cttgaagaat tttgtggtgg ctgaggatta ccatcaagac tatctcaaga
aaaatccaaa 540tggctactgc catatcaatg ttaatcaggc ggcctatcct
gtcattgatg ccagcaaata 600tccaaaacca agtgatgagg aattgaaaaa
gaccctgtca cctgaggagt atgcagttac 660ccaggaaaat caaacagaac
gagctttctc aaaccgttac tgggataaat ttgaatccgg 720tatctatgtg
gatatagcaa ctggggaacc tctcttttca tcaaaagaca aatttgagtc
780tggttgtggc tggcctagtt ttacccaacc catcagtcca gatgttgtca
cctacaagga 840agataagtcc tacaatatga cgcgtatgga agtgcggagc
cgagtaggag attctcacct 900tgggcatgtc tttacggatg gtccacagga
caagggcggc ttacgttact gtatcaatag 960cctctctatc cgctttattc
ccaaagacca aatggaagaa aaaggctacg cttatttact 1020agattatgtt gat
1033192344PRTStreptococcus pneumoniae 192Arg Asn Ala Gly Gln Thr
Asp Ala Ser Gln Ile Glu Lys Ala Ala Val1 5 10 15Ser Gln Gly Gly Lys
Ala Val Lys Lys Thr Glu Ile Ser Lys Asp Ala 20 25 30Asp Leu His Glu
Ile Tyr Leu Ala Gly Gly Cys Phe Trp Gly Val Glu 35 40 45Glu Tyr Phe
Ser Arg Val Pro Gly Val Thr Asp Ala Val Ser Gly Tyr 50 55 60Ala Asn
Gly Arg Gly Glu Thr Thr Lys Tyr Glu Leu Ile Asn Gln Thr65 70 75
80Gly His Ala Glu Thr Val His Val Thr Tyr Asp Ala Lys Gln Ile Ser
85 90 95Leu Lys Glu Ile Leu Leu His Tyr Phe Arg Ile Ile Asn Pro Thr
Ser 100 105 110Lys Asn Lys Gln Gly Asn Asp Val Gly Thr Gln Tyr Arg
Thr Gly Val 115 120 125Tyr Tyr Thr Asp Asp Lys Asp Leu Glu Val Ile
Asn Gln Val Phe Asp 130 135 140Glu Val Ala Lys Lys Tyr Asp Gln Pro
Leu Ala Val Glu Lys Glu Asn145 150 155 160Leu Lys Asn Phe Val Val
Ala Glu Asp Tyr His Gln Asp Tyr Leu Lys 165 170 175Lys Asn Pro Asn
Gly Tyr Cys His Ile Asn Val Asn Gln Ala Ala Tyr 180 185 190Pro Val
Ile Asp Ala Ser Lys Tyr Pro Lys Pro Ser Asp Glu Glu Leu 195 200
205Lys Lys Thr Leu Ser Pro Glu Glu Tyr Ala Val Thr Gln Glu Asn Gln
210 215 220Thr Glu Arg Ala Phe Ser Asn Arg Tyr Trp Asp Lys Phe Glu
Ser Gly225 230 235 240Ile Tyr Val Asp Ile Ala Thr Gly Glu Pro Leu
Phe Ser Ser Lys Asp 245 250 255Lys Phe Glu Ser Gly Cys Gly Trp Pro
Ser Phe Thr Gln Pro Ile Ser 260 265 270Pro Asp Val Val Thr Tyr Lys
Glu Asp Lys Ser Tyr Asn Met Thr Arg 275 280 285Met Glu Val Arg Ser
Arg Val Gly Asp Ser His Leu Gly His Val Phe 290 295 300Thr Asp Gly
Pro Gln Asp Lys Gly Gly Leu Arg Tyr Cys Ile Asn Ser305 310 315
320Leu Ser Ile Arg Phe Ile Pro Lys Asp Gln Met Glu Glu Lys Gly Tyr
325 330 335Ala Tyr Leu Leu Asp Tyr Val Asp
340193396DNAStreptococcus pneumoniaemisc_feature(35)..(35)n is a,
c, g, or t 193tgtatagttt ttagcgcttg ttcttctaat tctgntaaaa
atgaagaaaa tacttctaaa 60gagcatgcgc ctgataaaat agttttagat catgctttcg
gtcaaactat attagataaa 120aaacctgaaa gagttgcaac tattgcttgg
ggaaatcatg atgtagcatt agctttagga 180atagttcctg ttggattttc
aaaagcaaat tacggtgtaa gtgctgataa aggagtttta 240ccatggacag
aagaaaaaat caaagaacta aatggtaaag ctaacctatt tgacgatttg
300gatggactta actttgaagc aatatcaaat tctaaaccag atgttatctt
agcaggttat 360tctggtataa ctaaagaaga ttatgacact ctatca
396194132PRTStreptococcus pneumoniaeSITE(12)..(12)Xaa can be any
naturally occurring amino acid 194Cys Ile Val Phe Ser Ala Cys Ser
Ser Asn Ser Xaa Lys Asn Glu Glu1 5 10 15Asn Thr Ser Lys Glu His Ala
Pro Asp Lys Ile Val Leu Asp His Ala 20 25 30Phe Gly Gln Thr Ile Leu
Asp Lys Lys Pro Glu Arg Val Ala Thr Ile 35 40 45Ala Trp Gly Asn His
Asp Val Ala Leu Ala Leu Gly Ile Val Pro Val 50 55 60Gly Phe Ser Lys
Ala Asn Tyr Gly Val Ser Ala Asp Lys Gly Val Leu65 70 75 80Pro Trp
Thr Glu Glu Lys Ile Lys Glu Leu Asn Gly Lys Ala Asn Leu 85 90 95Phe
Asp Asp Leu Asp Gly Leu Asn Phe Glu Ala Ile Ser Asn Ser Lys 100 105
110Pro Asp Val Ile Leu Ala Gly Tyr Ser Gly Ile Thr Lys Glu Asp Tyr
115 120 125Asp Thr Leu Ser 130195844DNAStreptococcus pneumoniae
195gtgtgtcgag catattctga agcaaaccta tcaaaatata gaaattattt
tagttgatga 60cggttctacg gataattctg gggaaatttg tgatgctttt atgatgcaag
ataatcgtgt 120gcgagtattg catcaagaaa ataagggggg ggcagcacaa
gctaaaaata tggggattag 180tgtagctaag ggagagtaca tcacgattgt
tgattcagat gatatcgtaa aagaaaatat 240gattgaaact ctttatcagc
aagtccaaga aaaggatgca gatgttgtta tagggaatta 300ctataattat
gacgaaagtg acgggaattt ttatttttat gtaacagggc aagatttttg
360cgtcgaagaa ttagctatac aagaaattat gaaccgtcaa gcaggagatt
ggaaattcaa 420tagctcggcc tttatattgc cgacatttaa gttgattaaa
aaagaattat tcaatgaagt 480tcacttttca aatggtcgcc gctttgatga
tgaagcaact atgcatcgct tttatctttt 540agcctctaaa atcgtcttta
taaacgataa tctctatctg tatagaagac gttcaggaag 600catcatgaga
acggaatttg atctttcctg ggcaagagat attgttgaag tgttttctaa
660gaaaatatcg gattgtgtct tggctggttt ggatgtctcc gttctgcgta
ttcgatttgt 720caatctttta aaagattata agcaaacttt agaataccat
caattaacag atactgagga 780atataaagat atttgtttca gattaaagtt
gttttttgat gcagaacaaa gaaatggtaa 840aagt 844196281PRTStreptococcus
pneumoniae 196Cys Val Glu His Ile Leu Lys Gln Thr Tyr Gln Asn Ile
Glu Ile Ile1 5 10 15Leu Val Asp Asp Gly Ser Thr Asp Asn Ser Gly Glu
Ile Cys Asp Ala 20 25 30Phe Met Met Gln Asp Asn Arg Val Arg Val Leu
His Gln Glu Asn Lys 35 40 45Gly Gly Ala Ala Gln Ala Lys Asn Met Gly
Ile Ser Val Ala Lys Gly 50 55 60Glu Tyr Ile Thr Ile Val Asp Ser Asp
Asp Ile Val Lys Glu Asn Met65 70 75 80Ile Glu Thr Leu Tyr Gln Gln
Val Gln Glu Lys Asp Ala Asp Val Val 85 90 95Ile Gly Asn Tyr Tyr Asn
Tyr Asp Glu Ser Asp Gly Asn Phe Tyr Phe 100 105 110Tyr Val Thr Gly
Gln Asp Phe Cys Val Glu Glu Leu Ala Ile Gln Glu 115 120 125Ile Met
Asn Arg Gln Ala Gly Asp Trp Lys Phe Asn Ser Ser Ala Phe 130 135
140Ile Leu Pro Thr Phe Lys Leu Ile Lys Lys Glu Leu Phe Asn Glu
Val145 150 155 160His Phe Ser Asn Gly Arg Arg Phe Asp Asp Glu Ala
Thr Met His Arg 165 170 175Phe Tyr Leu Leu Ala Ser Lys Ile Val Phe
Ile Asn Asp Asn Leu Tyr 180 185 190Leu Tyr Arg Arg Arg Ser Gly Ser
Ile Met Arg Thr Glu Phe Asp Leu 195 200 205Ser Trp Ala Arg Asp Ile
Val Glu Val Phe Ser Lys Lys Ile Ser Asp 210 215 220Cys Val Leu Ala
Gly Leu Asp Val Ser Val Leu Arg Ile Arg Phe Val225 230 235 240Asn
Leu Leu Lys Asp Tyr Lys Gln Thr Leu Glu Tyr His Gln Leu Thr 245 250
255Asp Thr Glu Glu Tyr Lys Asp Ile Cys Phe Arg Leu Lys Leu Phe Phe
260 265 270Asp Ala Glu Gln Arg Asn Gly Lys Ser 275
280197811DNAStreptococcus pneumoniae 197gtgtttggat agcattcaga
atcagacgta tcaaaatttt gagtgtttat taatcaatga 60tggctctcca gatcattcat
ccaaaatatg tgaagaattt gtagagaaag attctcgttt 120caaatatttt
gagaaagcaa acggcggtct ttcatcagct cgtaacctag gtattgaatg
180ttcggggggg gcgtacatta cttttgtaga ctctgatgat tggttggaac
atgatgcttt 240agaccgatta tatggtgctt tgaaaaagga aaacgcagat
attagtatcg ggcgttataa 300ttcttatgat gaaacacgct atgtgtatat
gacttatgtt acggatccag atgattctct 360agaagtgata gaaggtaaag
caattatgga tagggaaggt gtcgaagaag tcagaaatgg 420gaactggact
gtagctgtct tgaagttatt caagagagag ttactacaag atttaccatt
480tcctatagga aaaattgcag aggatactta ctggacatgg aaggtacttc
taagagcttc 540gaggatagtc tatttgaatc gttgtgttta ctggtaccgt
gttggtttat ctgatacttt 600atcgaataca tggagtgaaa agcgtatgta
tgatgaaatt ggggctaggg aagaaaagat 660agctatttta gcaagttcag
actatgactt gaccaatcat attttgattt ataaaaatag 720attacaaaga
gtgatagcaa aattagaaga acaaaatatg cagttcacag agatttacag
780aagaatgatg gaaaaattgt ctttacttcc g 811198270PRTStreptococcus
pneumoniae 198Cys Leu Asp Ser Ile Gln Asn Gln Thr Tyr Gln Asn Phe
Glu Cys Leu1 5 10 15Leu Ile Asn Asp Gly Ser Pro Asp His Ser Ser Lys
Ile Cys Glu Glu 20 25 30Phe Val Glu Lys Asp Ser Arg Phe Lys Tyr Phe
Glu Lys Ala Asn Gly 35 40 45Gly Leu Ser Ser Ala Arg Asn Leu Gly Ile
Glu Cys Ser Gly Gly Ala 50 55 60Tyr Ile Thr Phe Val Asp Ser Asp Asp
Trp Leu Glu His Asp Ala Leu65 70 75 80Asp Arg Leu Tyr Gly Ala Leu
Lys Lys Glu Asn Ala Asp Ile Ser Ile 85 90 95Gly Arg Tyr Asn Ser Tyr
Asp Glu Thr Arg Tyr Val Tyr Met Thr Tyr 100 105 110Val Thr Asp Pro
Asp Asp Ser Leu Glu Val Ile Glu Gly Lys Ala Ile 115 120 125Met Asp
Arg Glu Gly Val Glu Glu Val Arg Asn Gly Asn Trp Thr Val 130 135
140Ala Val Leu Lys Leu Phe Lys Arg Glu Leu Leu Gln Asp Leu Pro
Phe145 150 155 160Pro Ile Gly Lys Ile Ala Glu Asp Thr Tyr Trp Thr
Trp Lys Val Leu 165 170 175Leu Arg Ala Ser Arg Ile Val Tyr Leu Asn
Arg Cys Val Tyr Trp Tyr 180 185 190Arg Val Gly Leu Ser Asp Thr Leu
Ser Asn Thr Trp Ser Glu Lys Arg 195 200 205Met Tyr Asp Glu Ile Gly
Ala Arg Glu Glu Lys Ile Ala Ile Leu Ala 210 215 220Ser Ser Asp Tyr
Asp Leu Thr Asn His Ile Leu Ile Tyr Lys Asn Arg225 230 235 240Leu
Gln Arg Val Ile Ala Lys Leu Glu Glu Gln Asn Met Gln Phe Thr 245 250
255Glu Ile Tyr Arg Arg Met Met Glu Lys Leu Ser Leu Leu Pro 260 265
2701992023DNAStreptococcus pneumoniae 199gtgcctagat agtattatta
ctcaaacata taaaaatatt gagattgttg tcgttaatga 60tggttctacg gatgcttcag
gtgaaatttg taaagaattt tcagaaatgg atcaccgaat 120tctctatata
gaacaagaaa atgctggtct ttctgccgca cgaaacaccg gtctgaataa
180tatgtccgga aattatgtga cctttgtgga ctcggatgat tggattgagc
aagattatgt 240agaaactcta tataaaaaaa tagtagagta tcaggctgat
attgcagttg gtaattatta 300ttctttcaac gaaagtgaag gaatgttcta
ctttcatata ttgggagact cctattatga 360gaaagtatat gataatgttt
ctatctttga gaacttgtat gaaactcaag aaatgaagag 420ttttgctttg
atatctgctt ggggtaaact ctataaggca agattgtttg agcagttgcg
480ctttgacata ggtaaattag gagaagatgg ttacctcaat caaaaggtat
atttattatc 540agaaaaggta atttatttaa ataaaagtct ttatgcttat
cggattagaa aaggtagttt 600atcaagagtt tggacagaaa agtggatgca
cgctttagtt gatgctatgt ctgaacgtat 660tacgctacta gctaatatgg
gttatcctct agagaaacac ttggcagttt atcgtcagat 720gttggaagtc
agtctcgcca acggtcaagc tagtggttta tctgacacag caacgtataa
780agagtttgaa atgaaacaaa ggcttttaaa
tcagctatcg agacaagagg aaagtgaaaa 840gaaagccatt gtcctcgcag
caaactatgg ctatgtagac caagttttaa cgacaatcaa 900gtctatttgt
tatcataatc gttcgattcg tttttatctg attcatagcg attttccaaa
960tgaatggatt aagcaattaa ataagcgctt agagaagttt gactcagaaa
ttattaattg 1020tcgggtaact tctgagcaaa tttcatgtta taaatcggat
attagttaca cagtcttttt 1080acgctatttc atagctgatt tcgtgcaaga
agacaaggcc ctctacttgg actgtgatct 1140agttgtaacg aaaaatctgg
atgacttgtt tgctacagac ttacaagatt atcctttggc 1200tgctgttaga
gattttgggg gcagagctta ttttggtcaa gaaatcttta atgccggtgt
1260tctcttggta aacaatgctt tttggaaaaa agagaatatg acccaaaaat
taattgatgt 1320aaccaatgaa tggcatgata aggtggatca ggcagatcag
agcatcttga atatgctttt 1380tgaacataaa tggttggaat tggactttga
ttataatcat attgtcattc ataaacagtt 1440tgctgattat caattgcctg
agggtcagga ttatcctgct attattcact atctttctca 1500tcggaaaccg
tggaaagatt tggcggccca aacctatcgt gaagtttggt ggtactatca
1560tgggcttgaa tggacagaat tgggacaaaa ccatcattta catccattac
aaagatctca 1620catctatcca ataaaggaac ctttcacttg tctaatctat
actgcctcag accatattga 1680acaaattgag acattggttc aatccttgcc
tgatattcag tttaagatag cagctagagt 1740aatagttagt gatcgattgg
ctcagatgac aatttatcca aacgtgacta tatttaacgg 1800aattcactat
ttggtagatg tcgataatga attggtagaa accagtcaag tacttttaga
1860tattaatcat ggcgaaaaga cagaagaaat tctcgatcaa tttgctaatc
ttggcaagcc 1920tatcttatcc tttgaaaata ctaaaaccta tgaagtaggt
caggaggcat atgctgttga 1980ccaagttcaa gcaatgattg aaaaattgag
agaaataagc aaa 2023200674PRTStreptococcus pneumoniae 200Cys Leu Asp
Ser Ile Ile Thr Gln Thr Tyr Lys Asn Ile Glu Ile Val1 5 10 15Val Val
Asn Asp Gly Ser Thr Asp Ala Ser Gly Glu Ile Cys Lys Glu 20 25 30Phe
Ser Glu Met Asp His Arg Ile Leu Tyr Ile Glu Gln Glu Asn Ala 35 40
45Gly Leu Ser Ala Ala Arg Asn Thr Gly Leu Asn Asn Met Ser Gly Asn
50 55 60Tyr Val Thr Phe Val Asp Ser Asp Asp Trp Ile Glu Gln Asp Tyr
Val65 70 75 80Glu Thr Leu Tyr Lys Lys Ile Val Glu Tyr Gln Ala Asp
Ile Ala Val 85 90 95Gly Asn Tyr Tyr Ser Phe Asn Glu Ser Glu Gly Met
Phe Tyr Phe His 100 105 110Ile Leu Gly Asp Ser Tyr Tyr Glu Lys Val
Tyr Asp Asn Val Ser Ile 115 120 125Phe Glu Asn Leu Tyr Glu Thr Gln
Glu Met Lys Ser Phe Ala Leu Ile 130 135 140Ser Ala Trp Gly Lys Leu
Tyr Lys Ala Arg Leu Phe Glu Gln Leu Arg145 150 155 160Phe Asp Ile
Gly Lys Leu Gly Glu Asp Gly Tyr Leu Asn Gln Lys Val 165 170 175Tyr
Leu Leu Ser Glu Lys Val Ile Tyr Leu Asn Lys Ser Leu Tyr Ala 180 185
190Tyr Arg Ile Arg Lys Gly Ser Leu Ser Arg Val Trp Thr Glu Lys Trp
195 200 205Met His Ala Leu Val Asp Ala Met Ser Glu Arg Ile Thr Leu
Leu Ala 210 215 220Asn Met Gly Tyr Pro Leu Glu Lys His Leu Ala Val
Tyr Arg Gln Met225 230 235 240Leu Glu Val Ser Leu Ala Asn Gly Gln
Ala Ser Gly Leu Ser Asp Thr 245 250 255Ala Thr Tyr Lys Glu Phe Glu
Met Lys Gln Arg Leu Leu Asn Gln Leu 260 265 270Ser Arg Gln Glu Glu
Ser Glu Lys Lys Ala Ile Val Leu Ala Ala Asn 275 280 285Tyr Gly Tyr
Val Asp Gln Val Leu Thr Thr Ile Lys Ser Ile Cys Tyr 290 295 300His
Asn Arg Ser Ile Arg Phe Tyr Leu Ile His Ser Asp Phe Pro Asn305 310
315 320Glu Trp Ile Lys Gln Leu Asn Lys Arg Leu Glu Lys Phe Asp Ser
Glu 325 330 335Ile Ile Asn Cys Arg Val Thr Ser Glu Gln Ile Ser Cys
Tyr Lys Ser 340 345 350Asp Ile Ser Tyr Thr Val Phe Leu Arg Tyr Phe
Ile Ala Asp Phe Val 355 360 365Gln Glu Asp Lys Ala Leu Tyr Leu Asp
Cys Asp Leu Val Val Thr Lys 370 375 380Asn Leu Asp Asp Leu Phe Ala
Thr Asp Leu Gln Asp Tyr Pro Leu Ala385 390 395 400Ala Val Arg Asp
Phe Gly Gly Arg Ala Tyr Phe Gly Gln Glu Ile Phe 405 410 415Asn Ala
Gly Val Leu Leu Val Asn Asn Ala Phe Trp Lys Lys Glu Asn 420 425
430Met Thr Gln Lys Leu Ile Asp Val Thr Asn Glu Trp His Asp Lys Val
435 440 445Asp Gln Ala Asp Gln Ser Ile Leu Asn Met Leu Phe Glu His
Lys Trp 450 455 460Leu Glu Leu Asp Phe Asp Tyr Asn His Ile Val Ile
His Lys Gln Phe465 470 475 480Ala Asp Tyr Gln Leu Pro Glu Gly Gln
Asp Tyr Pro Ala Ile Ile His 485 490 495Tyr Leu Ser His Arg Lys Pro
Trp Lys Asp Leu Ala Ala Gln Thr Tyr 500 505 510Arg Glu Val Trp Trp
Tyr Tyr His Gly Leu Glu Trp Thr Glu Leu Gly 515 520 525Gln Asn His
His Leu His Pro Leu Gln Arg Ser His Ile Tyr Pro Ile 530 535 540Lys
Glu Pro Phe Thr Cys Leu Ile Tyr Thr Ala Ser Asp His Ile Glu545 550
555 560Gln Ile Glu Thr Leu Val Gln Ser Leu Pro Asp Ile Gln Phe Lys
Ile 565 570 575Ala Ala Arg Val Ile Val Ser Asp Arg Leu Ala Gln Met
Thr Ile Tyr 580 585 590Pro Asn Val Thr Ile Phe Asn Gly Ile His Tyr
Leu Val Asp Val Asp 595 600 605Asn Glu Leu Val Glu Thr Ser Gln Val
Leu Leu Asp Ile Asn His Gly 610 615 620Glu Lys Thr Glu Glu Ile Leu
Asp Gln Phe Ala Asn Leu Gly Lys Pro625 630 635 640Ile Leu Ser Phe
Glu Asn Thr Lys Thr Tyr Glu Val Gly Gln Glu Ala 645 650 655Tyr Ala
Val Asp Gln Val Gln Ala Met Ile Glu Lys Leu Arg Glu Ile 660 665
670Ser Lys201910DNAStreptococcus pneumoniae 201cattcagaag
cagacctatc aaaatctgga aattattctt gttgatgatg gtgcaacaga 60tgaaagtggt
cgcttgtgtg attcaatcgc tgaacaagat gacagggtgt cagtgcttca
120taaaaagaac gaaggattgt cgcaagcacg aaatgatggg atgaagcagg
ctcacgggga 180ttatctgatt tttattgact cagatgatta tatccatcca
gaaatgattc agagcttata 240tgagcaatta gttcaagaag atgcggatgt
ttcgagctgt ggtgtcatga atgtctatgc 300taatgatgaa agcccacagt
cagccaatca ggatgactat tttgtctgtg attctcaaac 360atttctaaag
gaatacctca taggtgaaaa aatacctggg acgatttgca ataagctaat
420caagagacag attgcaactg ccctatcctt tcctaagggg ttgatttacg
aagatgccta 480ttaccatttt gatttaatca agttggccaa gaagtatgtg
gttaatacta aaccctatta 540ttactatttc catagagggg atagtattac
gaccaaaccc tatgcagaga aggatttagc 600ctatattgat atctaccaaa
agttttataa tgaagttgtg aaaaactatc ctgacttgaa 660agaggtcgct
tttttcagat tggcctatgc ccacttcttt attctggata agatgttgct
720agatgatcag tataaacagt ttgaagccta ttctcagatt catcgttttt
taaaaggcca 780tgcctttgct atttctagga atccaatttt ccgtaagggg
agaagaatta gtgctttggc 840cctattcata aatatttcct tatatcgatt
cttattactg aaaaatattg aaaaatctaa 900aaaattacat
910202303PRTStreptococcus pneumoniae 202Ile Gln Lys Gln Thr Tyr Gln
Asn Leu Glu Ile Ile Leu Val Asp Asp1 5 10 15Gly Ala Thr Asp Glu Ser
Gly Arg Leu Cys Asp Ser Ile Ala Glu Gln 20 25 30Asp Asp Arg Val Ser
Val Leu His Lys Lys Asn Glu Gly Leu Ser Gln 35 40 45Ala Arg Asn Asp
Gly Met Lys Gln Ala His Gly Asp Tyr Leu Ile Phe 50 55 60Ile Asp Ser
Asp Asp Tyr Ile His Pro Glu Met Ile Gln Ser Leu Tyr65 70 75 80Glu
Gln Leu Val Gln Glu Asp Ala Asp Val Ser Ser Cys Gly Val Met 85 90
95Asn Val Tyr Ala Asn Asp Glu Ser Pro Gln Ser Ala Asn Gln Asp Asp
100 105 110Tyr Phe Val Cys Asp Ser Gln Thr Phe Leu Lys Glu Tyr Leu
Ile Gly 115 120 125Glu Lys Ile Pro Gly Thr Ile Cys Asn Lys Leu Ile
Lys Arg Gln Ile 130 135 140Ala Thr Ala Leu Ser Phe Pro Lys Gly Leu
Ile Tyr Glu Asp Ala Tyr145 150 155 160Tyr His Phe Asp Leu Ile Lys
Leu Ala Lys Lys Tyr Val Val Asn Thr 165 170 175Lys Pro Tyr Tyr Tyr
Tyr Phe His Arg Gly Asp Ser Ile Thr Thr Lys 180 185 190Pro Tyr Ala
Glu Lys Asp Leu Ala Tyr Ile Asp Ile Tyr Gln Lys Phe 195 200 205Tyr
Asn Glu Val Val Lys Asn Tyr Pro Asp Leu Lys Glu Val Ala Phe 210 215
220Phe Arg Leu Ala Tyr Ala His Phe Phe Ile Leu Asp Lys Met Leu
Leu225 230 235 240Asp Asp Gln Tyr Lys Gln Phe Glu Ala Tyr Ser Gln
Ile His Arg Phe 245 250 255Leu Lys Gly His Ala Phe Ala Ile Ser Arg
Asn Pro Ile Phe Arg Lys 260 265 270Gly Arg Arg Ile Ser Ala Leu Ala
Leu Phe Ile Asn Ile Ser Leu Tyr 275 280 285Arg Phe Leu Leu Leu Lys
Asn Ile Glu Lys Ser Lys Lys Leu His 290 295
3002031972DNAStreptococcus pneumoniae 203taaggctgat aatcgtgttc
aaatgagaac gacgattaat aatgaatcgc cattgttgct 60ttctccgttg tatggcaatg
ataatggtaa cggattatgg tgggggaaca cattgaaggg 120agcatgggaa
gctattcctg aagatgtaaa gccatatgca gcgattgaac ttcatcctgc
180aaaagtctgt aaaccaacaa gttgtattcc acgagatacg aaagaattga
gagaatggta 240tgtcaagatg ttggaggaag ctcaaagtct aaacattcca
gttttcttgg ttattatgtc 300ggctggagag cgtaatacag ttcctccaga
gtggttagat gaacaattcc aaaagtatag 360tgtgttaaaa ggtgttttaa
atattgagaa ttattggatt tacaataacc agttagctcc 420gcatagtgct
aaatatttgg aagtttgtgc caaatatgga gcgcatttta tctggcatga
480tcatgaaaaa tggttctggg aaactattat gaatgatccg acattctttg
aagcgagtca 540aaaatatcat aaaaatttgg tgttggcaac taaaaatacg
ccaataagag atgatgcggg 600tacagattct atcgttagtg gattttggtt
gagtggctta tgtgataact ggggctcatc 660aacagataca tggaaatggt
gggaaaaaca ttatacaaac acatttgaaa ctggaagagc 720tagggatatg
agatcctatg catcggaacc agaatcaatg attgctatgg aaatgatgaa
780tgtatatact gggggaggca cagtttataa tttcgaatgt gccgcgtata
catttatgac 840aaatgatgta ccaactccag catttactaa aggtattatt
cctttcttta gacatgctat 900acaaaatcca gctccaagta aggaagaagt
tgtaaataga acaaaagctg tattttggaa 960tggagaaggt aggattagtt
cattaaacgg attttatcaa ggactttatt cgaatgatga 1020aacaatgcct
ttatataata atgggagata tcatattctt cctgtaatac atgagaaaat
1080tgataaggaa aagatttcat ctatattccc taatgcaaaa attttgacta
aaaatagtga 1140ggaattgtct agtaaagtca actatttaaa ctcgctttat
ccaaaacttt atgaaggaga 1200tgggtatgct cagcgtgtag gtaattcctg
gtatatttat aatagtaatg ctaatatcaa 1260taaaaatcag caagtaatgt
tgcctatgta tactaataat acaaagtcgt tatcgttaga 1320tttgacgcca
catacttacg ctgttgttaa agaaaatcca aataatttac atattttatt
1380gaataattac aggacagata agacagctat gtgggcatta tcaggaaatt
ttgatgcatc 1440aaaaagttgg aagaaagaag aattagagtt agcgaactgg
ataagcaaaa attattccat 1500caatcctgta gataatgact ttaggacaac
aacacttaca ttaaaagggc atactggtca 1560taaacctcag ataaatataa
gtggcgataa aaatcattat acttatacag aaaattggga 1620tgagaatacc
catgtttata ccattacggt taatcataat ggaatggtag agatgtctat
1680aaatactgag gggacaggtc cagtctcttt cccaacacca gataaattta
atgatggtaa 1740tttgaatata gcatatgcaa aaccaacaac acaaagttct
gtagattaca atggagaccc 1800taatagagct gtggatggta acagaaatgg
taattttaac tctggttcgg taacacacac 1860tagggcagat aatccctctt
ggtgggaagt cgatttgaaa aaaatggata aagttgggct 1920tgttaaaatt
tataatcgca cagatgctga gactcaacgt ctatctaatt tt
1972204657PRTStreptococcus pneumoniae 204Lys Ala Asp Asn Arg Val
Gln Met Arg Thr Thr Ile Asn Asn Glu Ser1 5 10 15Pro Leu Leu Leu Ser
Pro Leu Tyr Gly Asn Asp Asn Gly Asn Gly Leu 20 25 30Trp Trp Gly Asn
Thr Leu Lys Gly Ala Trp Glu Ala Ile Pro Glu Asp 35 40 45Val Lys Pro
Tyr Ala Ala Ile Glu Leu His Pro Ala Lys Val Cys Lys 50 55 60Pro Thr
Ser Cys Ile Pro Arg Asp Thr Lys Glu Leu Arg Glu Trp Tyr65 70 75
80Val Lys Met Leu Glu Glu Ala Gln Ser Leu Asn Ile Pro Val Phe Leu
85 90 95Val Ile Met Ser Ala Gly Glu Arg Asn Thr Val Pro Pro Glu Trp
Leu 100 105 110Asp Glu Gln Phe Gln Lys Tyr Ser Val Leu Lys Gly Val
Leu Asn Ile 115 120 125Glu Asn Tyr Trp Ile Tyr Asn Asn Gln Leu Ala
Pro His Ser Ala Lys 130 135 140Tyr Leu Glu Val Cys Ala Lys Tyr Gly
Ala His Phe Ile Trp His Asp145 150 155 160His Glu Lys Trp Phe Trp
Glu Thr Ile Met Asn Asp Pro Thr Phe Phe 165 170 175Glu Ala Ser Gln
Lys Tyr His Lys Asn Leu Val Leu Ala Thr Lys Asn 180 185 190Thr Pro
Ile Arg Asp Asp Ala Gly Thr Asp Ser Ile Val Ser Gly Phe 195 200
205Trp Leu Ser Gly Leu Cys Asp Asn Trp Gly Ser Ser Thr Asp Thr Trp
210 215 220Lys Trp Trp Glu Lys His Tyr Thr Asn Thr Phe Glu Thr Gly
Arg Ala225 230 235 240Arg Asp Met Arg Ser Tyr Ala Ser Glu Pro Glu
Ser Met Ile Ala Met 245 250 255Glu Met Met Asn Val Tyr Thr Gly Gly
Gly Thr Val Tyr Asn Phe Glu 260 265 270Cys Ala Ala Tyr Thr Phe Met
Thr Asn Asp Val Pro Thr Pro Ala Phe 275 280 285Thr Lys Gly Ile Ile
Pro Phe Phe Arg His Ala Ile Gln Asn Pro Ala 290 295 300Pro Ser Lys
Glu Glu Val Val Asn Arg Thr Lys Ala Val Phe Trp Asn305 310 315
320Gly Glu Gly Arg Ile Ser Ser Leu Asn Gly Phe Tyr Gln Gly Leu Tyr
325 330 335Ser Asn Asp Glu Thr Met Pro Leu Tyr Asn Asn Gly Arg Tyr
His Ile 340 345 350Leu Pro Val Ile His Glu Lys Ile Asp Lys Glu Lys
Ile Ser Ser Ile 355 360 365Phe Pro Asn Ala Lys Ile Leu Thr Lys Asn
Ser Glu Glu Leu Ser Ser 370 375 380Lys Val Asn Tyr Leu Asn Ser Leu
Tyr Pro Lys Leu Tyr Glu Gly Asp385 390 395 400Gly Tyr Ala Gln Arg
Val Gly Asn Ser Trp Tyr Ile Tyr Asn Ser Asn 405 410 415Ala Asn Ile
Asn Lys Asn Gln Gln Val Met Leu Pro Met Tyr Thr Asn 420 425 430Asn
Thr Lys Ser Leu Ser Leu Asp Leu Thr Pro His Thr Tyr Ala Val 435 440
445Val Lys Glu Asn Pro Asn Asn Leu His Ile Leu Leu Asn Asn Tyr Arg
450 455 460Thr Asp Lys Thr Ala Met Trp Ala Leu Ser Gly Asn Phe Asp
Ala Ser465 470 475 480Lys Ser Trp Lys Lys Glu Glu Leu Glu Leu Ala
Asn Trp Ile Ser Lys 485 490 495Asn Tyr Ser Ile Asn Pro Val Asp Asn
Asp Phe Arg Thr Thr Thr Leu 500 505 510Thr Leu Lys Gly His Thr Gly
His Lys Pro Gln Ile Asn Ile Ser Gly 515 520 525Asp Lys Asn His Tyr
Thr Tyr Thr Glu Asn Trp Asp Glu Asn Thr His 530 535 540Val Tyr Thr
Ile Thr Val Asn His Asn Gly Met Val Glu Met Ser Ile545 550 555
560Asn Thr Glu Gly Thr Gly Pro Val Ser Phe Pro Thr Pro Asp Lys Phe
565 570 575Asn Asp Gly Asn Leu Asn Ile Ala Tyr Ala Lys Pro Thr Thr
Gln Ser 580 585 590Ser Val Asp Tyr Asn Gly Asp Pro Asn Arg Ala Val
Asp Gly Asn Arg 595 600 605Asn Gly Asn Phe Asn Ser Gly Ser Val Thr
His Thr Arg Ala Asp Asn 610 615 620Pro Ser Trp Trp Glu Val Asp Leu
Lys Lys Met Asp Lys Val Gly Leu625 630 635 640Val Lys Ile Tyr Asn
Arg Thr Asp Ala Glu Thr Gln Arg Leu Ser Asn 645 650
655Phe205811DNAStreptococcus pneumoniae 205ctgtggcaat cagtcagctg
cttccaaaca gtcagcttca ggaacgattg aggtgatttc 60acgagaaaat ggctctggga
cacggggtgc cttcacagaa atcacaggga ttctcaaaaa 120agacggtgat
aaaaaaattg acaacactgc caaaacagct gtgattcaaa atagtacaga
180aggtgttctc tcagcagttc aagggaatgc taatgctatc ggctacatct
ccttgggatc 240tttaacgaaa tctgtcaagg ctttagagat tgatggtgtc
aaggctagtc gagacacagt 300tttagatggt gaataccctc ttcaacgtcc
cttcaacatt gtttggtctt ctaatctttc 360caagctaggt caagatttta
tcagctttat ccactccaaa caaggtcaac aagtggtcac 420agataataaa
tttattgaag ctaaaaccga aaccacggaa tatacaagcc aacacttatc
480aggcaagttg tctgttgtag gttccacttc agtatcttct ttaatggaaa
aattagcaga 540agcttataaa aaagaaaatc cagaagttac gattgatatt
acctctaatg ggtcttcagc 600aggtattacc gctgttaagg agaaaaccgc
tgatattggt atggtttcta gggaattaac 660tcctgaagaa ggtaagagtc
tcacccatga tgctattgct ttagacggta ttgctgttgt 720ggtcaataat
gacaataagg
caagccaagt cagtatggct gaacttgcag acgtttttag 780tggcaaatta
accacctggg acaagattaa a 811206270PRTStreptococcus pneumoniae 206Cys
Gly Asn Gln Ser Ala Ala Ser Lys Gln Ser Ala Ser Gly Thr Ile1 5 10
15Glu Val Ile Ser Arg Glu Asn Gly Ser Gly Thr Arg Gly Ala Phe Thr
20 25 30Glu Ile Thr Gly Ile Leu Lys Lys Asp Gly Asp Lys Lys Ile Asp
Asn 35 40 45Thr Ala Lys Thr Ala Val Ile Gln Asn Ser Thr Glu Gly Val
Leu Ser 50 55 60Ala Val Gln Gly Asn Ala Asn Ala Ile Gly Tyr Ile Ser
Leu Gly Ser65 70 75 80Leu Thr Lys Ser Val Lys Ala Leu Glu Ile Asp
Gly Val Lys Ala Ser 85 90 95Arg Asp Thr Val Leu Asp Gly Glu Tyr Pro
Leu Gln Arg Pro Phe Asn 100 105 110Ile Val Trp Ser Ser Asn Leu Ser
Lys Leu Gly Gln Asp Phe Ile Ser 115 120 125Phe Ile His Ser Lys Gln
Gly Gln Gln Val Val Thr Asp Asn Lys Phe 130 135 140Ile Glu Ala Lys
Thr Glu Thr Thr Glu Tyr Thr Ser Gln His Leu Ser145 150 155 160Gly
Lys Leu Ser Val Val Gly Ser Thr Ser Val Ser Ser Leu Met Glu 165 170
175Lys Leu Ala Glu Ala Tyr Lys Lys Glu Asn Pro Glu Val Thr Ile Asp
180 185 190Ile Thr Ser Asn Gly Ser Ser Ala Gly Ile Thr Ala Val Lys
Glu Lys 195 200 205Thr Ala Asp Ile Gly Met Val Ser Arg Glu Leu Thr
Pro Glu Glu Gly 210 215 220Lys Ser Leu Thr His Asp Ala Ile Ala Leu
Asp Gly Ile Ala Val Val225 230 235 240Val Asn Asn Asp Asn Lys Ala
Ser Gln Val Ser Met Ala Glu Leu Ala 245 250 255Asp Val Phe Ser Gly
Lys Leu Thr Thr Trp Asp Lys Ile Lys 260 265
270207805DNAStreptococcus pneumoniae 207ttgtcaacaa caacatgcta
cttctgaggg gacgaatcaa aggcaaagca gttcagcgaa 60agttccatgg aaagcttcat
acaccaacct aaacaaccag gtaagtacag aagaggtcaa 120atctctctta
tcagctcact tggatccaaa tagtgttgat gcatttttta atctcgttaa
180tgactataat accattgtcg gctcaactgg cttatcagga gatttcactt
cctttactca 240caccgaatac gatgttgaga aaatcagtca tctctggaat
caaaagaagg gcgattttgt 300tgggaccaac tgccgtatca atagttattg
tcttttgaaa aattcagtca ccattccaaa 360gcttgaaaag aatgaccagt
tgcttttcct agataatgat gcgattgata aaggaaaggt 420ctttgattca
caagataagg aagagtttga tattctattt tcgagagttc caactgagtc
480aactacagat gtcaaggttc acgctgaaaa gatggaagca ttcttctcac
aatttcaatt 540caatgaaaaa gctcgaatgc tgtctgtagt cttgcacgac
aatttggatg gcgagtatct 600gtttgtaggc cacgttgggg tcttagtacc
tgctgatgac ggtttcttat ttgtagagaa 660attgactttc gaagagccct
accaagcgat taaatttgct agtaaggaag attgctacaa 720gtatttgggc
accaagtatg cggattatac aggcgaggga ctggctaagc cttttatcat
780ggataatgat aagtgggtta aactt 805208268PRTStreptococcus pneumoniae
208Cys Gln Gln Gln His Ala Thr Ser Glu Gly Thr Asn Gln Arg Gln Ser1
5 10 15Ser Ser Ala Lys Val Pro Trp Lys Ala Ser Tyr Thr Asn Leu Asn
Asn 20 25 30Gln Val Ser Thr Glu Glu Val Lys Ser Leu Leu Ser Ala His
Leu Asp 35 40 45Pro Asn Ser Val Asp Ala Phe Phe Asn Leu Val Asn Asp
Tyr Asn Thr 50 55 60Ile Val Gly Ser Thr Gly Leu Ser Gly Asp Phe Thr
Ser Phe Thr His65 70 75 80Thr Glu Tyr Asp Val Glu Lys Ile Ser His
Leu Trp Asn Gln Lys Lys 85 90 95Gly Asp Phe Val Gly Thr Asn Cys Arg
Ile Asn Ser Tyr Cys Leu Leu 100 105 110Lys Asn Ser Val Thr Ile Pro
Lys Leu Glu Lys Asn Asp Gln Leu Leu 115 120 125Phe Leu Asp Asn Asp
Ala Ile Asp Lys Gly Lys Val Phe Asp Ser Gln 130 135 140Asp Lys Glu
Glu Phe Asp Ile Leu Phe Ser Arg Val Pro Thr Glu Ser145 150 155
160Thr Thr Asp Val Lys Val His Ala Glu Lys Met Glu Ala Phe Phe Ser
165 170 175Gln Phe Gln Phe Asn Glu Lys Ala Arg Met Leu Ser Val Val
Leu His 180 185 190Asp Asn Leu Asp Gly Glu Tyr Leu Phe Val Gly His
Val Gly Val Leu 195 200 205Val Pro Ala Asp Asp Gly Phe Leu Phe Val
Glu Lys Leu Thr Phe Glu 210 215 220Glu Pro Tyr Gln Ala Ile Lys Phe
Ala Ser Lys Glu Asp Cys Tyr Lys225 230 235 240Tyr Leu Gly Thr Lys
Tyr Ala Asp Tyr Thr Gly Glu Gly Leu Ala Lys 245 250 255Pro Phe Ile
Met Asp Asn Asp Lys Trp Val Lys Leu 260 265209508DNAStreptococcus
pneumoniae 209ttgttcaggc aagtccgtga ctagtgaaca ccaaacgaaa
gatgaaatga agacggagca 60gacagctagt aaaacaagcg cagctaaagg gaaagaggtg
gctgattttg aattgatggg 120agtagatggc aagacctacc gtttatctga
ttacaagggc aagaaagtct atctcaaatt 180ctgggcttct tggtgttcca
tctgtctggc tagtcttcca gatacggatg agattgctaa 240agaagctggt
gatgactatg tggtcttgac agtagtgtca ccaggacata agggagagca
300atctgaagcg gactttaaga attggtataa gggattggat tataaaaatc
tcccagtcct 360agttgaccca tcaggcaaac ttttggaaac ttatggtgtc
cgttcttacc caacccaagc 420ctttatagac aaagaaggca agctggtcaa
aacacatcca ggattcatgg aaaaagatgc 480aattttgcaa actttgaagg aattagcc
508210169PRTStreptococcus pneumoniae 210Cys Ser Gly Lys Ser Val Thr
Ser Glu His Gln Thr Lys Asp Glu Met1 5 10 15Lys Thr Glu Gln Thr Ala
Ser Lys Thr Ser Ala Ala Lys Gly Lys Glu 20 25 30Val Ala Asp Phe Glu
Leu Met Gly Val Asp Gly Lys Thr Tyr Arg Leu 35 40 45Ser Asp Tyr Lys
Gly Lys Lys Val Tyr Leu Lys Phe Trp Ala Ser Trp 50 55 60Cys Ser Ile
Cys Leu Ala Ser Leu Pro Asp Thr Asp Glu Ile Ala Lys65 70 75 80Glu
Ala Gly Asp Asp Tyr Val Val Leu Thr Val Val Ser Pro Gly His 85 90
95Lys Gly Glu Gln Ser Glu Ala Asp Phe Lys Asn Trp Tyr Lys Gly Leu
100 105 110Asp Tyr Lys Asn Leu Pro Val Leu Val Asp Pro Ser Gly Lys
Leu Leu 115 120 125Glu Thr Tyr Gly Val Arg Ser Tyr Pro Thr Gln Ala
Phe Ile Asp Lys 130 135 140Glu Gly Lys Leu Val Lys Thr His Pro Gly
Phe Met Glu Lys Asp Ala145 150 155 160Ile Leu Gln Thr Leu Lys Glu
Leu Ala 165211994DNAStreptococcus pneumoniae 211ctcgcaaatt
gaaaaggcgg cagttagcca aggaggaaaa gcagtgaaaa aaacagaaat 60tagtaaagac
gcagacttgc acgaaattta tctagctgga ggttgtttct ggggagtgga
120ggaatatttc tcacgtgttc ccggggtgac ggatgccgtt tcaggctatg
caaatggtag 180aggagaaaca accaagtacg aattgattaa ccaaacaggt
catgcagaaa ccgtccatgt 240cacctatgat gccaagcaaa tttctctcaa
ggaaatcctg cttcactatt tccgcattat 300caatccaacc agcaaaaata
aacaaggaaa tgatgtgggg acccagtacc gtactggtgt 360ttattacaca
gatgacaagg atttggaagt gattaaccaa gtctttgatg aggtggctaa
420gaaatacgat caacctctag cagttgaaaa ggaaaacttg aagaattttg
tggtggctga 480ggattaccat caagactatc tcaagaaaaa tccaaatggc
tactgccata tcaatgttaa 540tcaggcggcc tatcctgtca ttgatgccag
caaatatcca aaaccaagtg atgaggaatt 600gaaaaagacc ctgtcacctg
aggagtatgc agttacccag gaaaatcaaa cagaacgagc 660tttctcaaac
cgttactggg ataaatttga atccggtatc tatgtggata tagcaactgg
720ggaacctctc ttttcatcaa aagacaaatt tgagtctggt tgtggctggc
ctagttttac 780ccaacccatc agtccagatg ttgtcaccta caaggaagat
aagtcctaca atatgacgcg 840tatggaagtg cggagccgag taggagattc
tcaccttggg catgtcttta cggatggtcc 900acaggacaag ggcggcttac
gttactgtat caatagcctc tctatccgct ttattcccaa 960agaccaaatg
gaagaaaaag gtacgcttat ttac 994212331PRTStreptococcus pneumoniae
212Ser Gln Ile Glu Lys Ala Ala Val Ser Gln Gly Gly Lys Ala Val Lys1
5 10 15Lys Thr Glu Ile Ser Lys Asp Ala Asp Leu His Glu Ile Tyr Leu
Ala 20 25 30Gly Gly Cys Phe Trp Gly Val Glu Glu Tyr Phe Ser Arg Val
Pro Gly 35 40 45Val Thr Asp Ala Val Ser Gly Tyr Ala Asn Gly Arg Gly
Glu Thr Thr 50 55 60Lys Tyr Glu Leu Ile Asn Gln Thr Gly His Ala Glu
Thr Val His Val65 70 75 80Thr Tyr Asp Ala Lys Gln Ile Ser Leu Lys
Glu Ile Leu Leu His Tyr 85 90 95Phe Arg Ile Ile Asn Pro Thr Ser Lys
Asn Lys Gln Gly Asn Asp Val 100 105 110Gly Thr Gln Tyr Arg Thr Gly
Val Tyr Tyr Thr Asp Asp Lys Asp Leu 115 120 125Glu Val Ile Asn Gln
Val Phe Asp Glu Val Ala Lys Lys Tyr Asp Gln 130 135 140Pro Leu Ala
Val Glu Lys Glu Asn Leu Lys Asn Phe Val Val Ala Glu145 150 155
160Asp Tyr His Gln Asp Tyr Leu Lys Lys Asn Pro Asn Gly Tyr Cys His
165 170 175Ile Asn Val Asn Gln Ala Ala Tyr Pro Val Ile Asp Ala Ser
Lys Tyr 180 185 190Pro Lys Pro Ser Asp Glu Glu Leu Lys Lys Thr Leu
Ser Pro Glu Glu 195 200 205Tyr Ala Val Thr Gln Glu Asn Gln Thr Glu
Arg Ala Phe Ser Asn Arg 210 215 220Tyr Trp Asp Lys Phe Glu Ser Gly
Ile Tyr Val Asp Ile Ala Thr Gly225 230 235 240Glu Pro Leu Phe Ser
Ser Lys Asp Lys Phe Glu Ser Gly Cys Gly Trp 245 250 255Pro Ser Phe
Thr Gln Pro Ile Ser Pro Asp Val Val Thr Tyr Lys Glu 260 265 270Asp
Lys Ser Tyr Asn Met Thr Arg Met Glu Val Arg Ser Arg Val Gly 275 280
285Asp Ser His Leu Gly His Val Phe Thr Asp Gly Pro Gln Asp Lys Gly
290 295 300Gly Leu Arg Tyr Cys Ile Asn Ser Leu Ser Ile Arg Phe Ile
Pro Lys305 310 315 320Asp Gln Met Glu Glu Lys Gly Thr Leu Ile Tyr
325 330213625DNAStreptococcus pneumoniae 213ttgtcagtca ggttctaatg
gttctcagtc tgctgtggat gctatcaaac aaaaagggaa 60attagttgtg gcaaccagtc
ctgactatgc accctttgaa tttcaatcat tggttgatgg 120aaagaaccag
gtagtcggtg cagacatcga catggctcag gctatcgctg atgaacttgg
180ggttaagttg gaaatctcaa gcatgagttt tgacaatgtt ttgaccagtc
ttcaaactgg 240taaggctgac ctagcagttg caggaattag tgctactgac
gagagaaaag aagtctttga 300tttttcaatc ccatactatg aaaacaagat
tagtttcttg gttcgtaagg ctgatgtgga 360aaaatacaag gatttaacta
gcctagaaag tgctaatatt gcagcccaaa aagggactgt 420tccagaatca
atggtcaagg aacaattgcc aaaagttcaa ttaacttccc taactaatat
480gggtgaagca gtcaatgaat tgcaggctgg aaaaatagat gctgttcata
tggatgagcc 540tgttgcactt agttatgctg ctaaaaacgc tggcttagct
gtcgcaactg tcagcttgaa 600gatgaaggac ggcgacgcca atgcc
625214208PRTStreptococcus pneumoniae 214Cys Gln Ser Gly Ser Asn Gly
Ser Gln Ser Ala Val Asp Ala Ile Lys1 5 10 15Gln Lys Gly Lys Leu Val
Val Ala Thr Ser Pro Asp Tyr Ala Pro Phe 20 25 30Glu Phe Gln Ser Leu
Val Asp Gly Lys Asn Gln Val Val Gly Ala Asp 35 40 45Ile Asp Met Ala
Gln Ala Ile Ala Asp Glu Leu Gly Val Lys Leu Glu 50 55 60Ile Ser Ser
Met Ser Phe Asp Asn Val Leu Thr Ser Leu Gln Thr Gly65 70 75 80Lys
Ala Asp Leu Ala Val Ala Gly Ile Ser Ala Thr Asp Glu Arg Lys 85 90
95Glu Val Phe Asp Phe Ser Ile Pro Tyr Tyr Glu Asn Lys Ile Ser Phe
100 105 110Leu Val Arg Lys Ala Asp Val Glu Lys Tyr Lys Asp Leu Thr
Ser Leu 115 120 125Glu Ser Ala Asn Ile Ala Ala Gln Lys Gly Thr Val
Pro Glu Ser Met 130 135 140Val Lys Glu Gln Leu Pro Lys Val Gln Leu
Thr Ser Leu Thr Asn Met145 150 155 160Gly Glu Ala Val Asn Glu Leu
Gln Ala Gly Lys Ile Asp Ala Val His 165 170 175Met Asp Glu Pro Val
Ala Leu Ser Tyr Ala Ala Lys Asn Ala Gly Leu 180 185 190Ala Val Ala
Thr Val Ser Leu Lys Met Lys Asp Gly Asp Ala Asn Ala 195 200
2052153022DNAStreptococcus pneumoniae 215ggaaacttca caggatttta
aagagaagaa aacagcagtc attaaggaaa aagaagttgt 60tagtaaaaat cctgtgatag
acaataacac tagcaatgaa gaagcaaaaa tcaaagaaga 120aaattccaat
aaatcccaag gagattatac ggactcattt gtgaataaaa acacagaaaa
180tcccaaaaaa gaagataaag ttgtctatat tgctgaattt aaagataaag
aatctggaga 240aaaagcaatc aaggaactat ccagtcttaa gaatacaaaa
gttttatata cttatgatag 300aatttttaac ggtagtgcca tagaaacaac
tccagataac ttggacaaaa ttaaacaaat 360agaaggtatt tcatcggttg
aaagggcaca aaaagtccaa cccatgatga atcatgccag 420aaaggaaatt
ggagttgagg aagctattga ttacctaaag tctatcaatg ctccgtttgg
480gaaaaatttt gatggtagag gtatggtcat ttcaaatatc gatactggaa
cagattatag 540acataaggct atgagaatcg atgatgatgc caaagcctca
atgagattta aaaaagaaga 600cttaaaaggc actgataaaa attattggtt
gagtgataaa atccctcatg cgttcaatta 660ttataatggt ggcaaaatca
ctgtagaaaa atatgatgat ggaagggatt attttgaccc 720acatgggatg
catattgcag ggattcttgc tggaaatgat actgaacaag acatcaaaaa
780ctttaacggc atagatggaa ttgcacctaa tgcacaaatt ttctcttaca
aaatgtattc 840tgacgcagga tctgggtttg cgggtgatga aacaatgttt
catgctattg aagattctat 900caaacacaac gttgatgttg tttcggtatc
atctggtttt acaggaacag gtcttgtagg 960tgagaaatat tggcaagcta
ttcgggcatt aagaaaagca ggcattccaa tggttgtcgc 1020tacgggtaac
tatgcgactt ctgcttcaag ttcttcatgg gatttagtag caaataatca
1080tctgaaaatg accgacactg gaaatgtaac acgaactgca gcacatgaag
atgcgatagc 1140ggtcgcttct gctaaaaatc aaacagttga gtttgataaa
gttaacatag gtggagaaag 1200ttttaaatac agaaatatag gggccttttt
cgataagagt aaaatcacaa caaatgaaga 1260tggaacaaaa gctcctagta
aattaaaatt tgtatatata ggcaaggggc aagaccaaga 1320tttgataggt
ttggatctta ggggcaaaat tgcagtaatg gatagaattt atacaaagga
1380tttaaaaaat gcttttaaaa aagctatgga taagggtgca cgcgccatta
tggttgtaaa 1440tactgtaaat tactacaata gagataattg gacagagctt
ccagctatgg gatatgaagc 1500ggatgaaggt actaaaagtc aagtgttttc
aatttcagga gatgatggtg taaagctatg 1560gaacatgatt aatcctgata
aaaaaactga agtcaaaaga aataataaag aagattttaa 1620agataaattg
gagcaatact atccaattga tatggaaagt tttaattcca acaaaccgaa
1680tgtaggtgac gaaaaagaga ttgactttaa gtttgcacct gacacagaca
aagaactcta 1740taaagaagat atcatcgttc cagcaggatc tacatcttgg
gggccaagaa tagatttact 1800tttaaaaccc gatgtttcag cacctggtaa
aaatattaaa tccacgctta atgttattaa 1860tggcaaatca acttatggct
atatgtcagg aactagtatg gcgactccaa tcgtggcagc 1920ttctactgtt
ttgattagac cgaaattaaa ggaaatgctt gaaagacctg tattgaaaaa
1980tcttaaggga gatgacaaaa tagatcttac aagtcttaca aaaattgccc
tacaaaatac 2040tgcgcgacct atgatggatg caacttcttg gaaagaaaaa
agtcaatact ttgcatcacc 2100tagacaacag ggagcaggcc taattaatgt
ggccaatgct ttgagaaatg aagttgtagc 2160aactttcaaa aacactgatt
ctaaaggttt ggtaaactca tatggttcca tttctcttaa 2220agaaataaaa
ggtgataaaa aatactttac aatcaagctt cacaatacat caaacagacc
2280tttgactttt aaagtttcag catcagcgat aactacagat tctctaactg
acagattaaa 2340acttgatgaa acatataaag atgaaaaatc tccagatggt
aagcaaattg ttccagaaat 2400tcacccagaa aaagtcaaag gagcaaatat
cacatttgag catgatactt tcactatagg 2460cgcaaattct agctttgatt
tgaatgcggt tataaatgtt ggagaggcca aaaacaaaaa 2520taaatttgta
gaatcattta ttcattttga gtcagtggaa gcgatggaag ctctaaactc
2580cagcgggaag aaaataaact tccaaccttc tttgtcgatg cctctaatgg
gatttgctgg 2640gaattggaac cacgaaccaa tccttgataa atgggcttgg
gaagaagggt caagatcaaa 2700aacactggga ggttatgatg atgatggtaa
accgaaaatt ccaggaacct taaataaggg 2760aattggtgga gaacatggta
tagataaatt taatccagca ggagttatac aaaatagaaa 2820agataaaaat
acaacatccc tggatcaaaa tccagaatta tttgctttca ataacgaagg
2880gatcaacgct ccatcatcaa gtggttctaa gattgctaac atttatcctt
tagattcaaa 2940tggaaatcct caagatgctc aacttgaaag aggattaaca
ccttctccac ttgtattaag 3000aagtgcagaa gaaggattga tt
30222161007PRTStreptococcus pneumoniae 216Glu Thr Ser Gln Asp Phe
Lys Glu Lys Lys Thr Ala Val Ile Lys Glu1 5 10 15Lys Glu Val Val Ser
Lys Asn Pro Val Ile Asp Asn Asn Thr Ser Asn 20 25 30Glu Glu Ala Lys
Ile Lys Glu Glu Asn Ser Asn Lys Ser Gln Gly Asp 35 40 45Tyr Thr Asp
Ser Phe Val Asn Lys Asn Thr Glu Asn Pro Lys Lys Glu 50 55 60Asp Lys
Val Val Tyr Ile Ala Glu Phe Lys Asp Lys Glu Ser Gly Glu65 70 75
80Lys Ala Ile Lys Glu Leu Ser Ser Leu Lys Asn Thr Lys Val Leu Tyr
85 90 95Thr Tyr Asp Arg Ile Phe Asn Gly Ser Ala Ile Glu Thr Thr Pro
Asp 100 105 110Asn Leu Asp Lys Ile Lys Gln Ile Glu Gly Ile Ser Ser
Val Glu Arg 115 120 125Ala Gln Lys Val Gln Pro Met Met Asn His Ala
Arg Lys Glu Ile Gly 130 135 140Val Glu Glu Ala Ile Asp Tyr Leu Lys
Ser Ile Asn Ala Pro Phe Gly145
150 155 160Lys Asn Phe Asp Gly Arg Gly Met Val Ile Ser Asn Ile Asp
Thr Gly 165 170 175Thr Asp Tyr Arg His Lys Ala Met Arg Ile Asp Asp
Asp Ala Lys Ala 180 185 190Ser Met Arg Phe Lys Lys Glu Asp Leu Lys
Gly Thr Asp Lys Asn Tyr 195 200 205Trp Leu Ser Asp Lys Ile Pro His
Ala Phe Asn Tyr Tyr Asn Gly Gly 210 215 220Lys Ile Thr Val Glu Lys
Tyr Asp Asp Gly Arg Asp Tyr Phe Asp Pro225 230 235 240His Gly Met
His Ile Ala Gly Ile Leu Ala Gly Asn Asp Thr Glu Gln 245 250 255Asp
Ile Lys Asn Phe Asn Gly Ile Asp Gly Ile Ala Pro Asn Ala Gln 260 265
270Ile Phe Ser Tyr Lys Met Tyr Ser Asp Ala Gly Ser Gly Phe Ala Gly
275 280 285Asp Glu Thr Met Phe His Ala Ile Glu Asp Ser Ile Lys His
Asn Val 290 295 300Asp Val Val Ser Val Ser Ser Gly Phe Thr Gly Thr
Gly Leu Val Gly305 310 315 320Glu Lys Tyr Trp Gln Ala Ile Arg Ala
Leu Arg Lys Ala Gly Ile Pro 325 330 335Met Val Val Ala Thr Gly Asn
Tyr Ala Thr Ser Ala Ser Ser Ser Ser 340 345 350Trp Asp Leu Val Ala
Asn Asn His Leu Lys Met Thr Asp Thr Gly Asn 355 360 365Val Thr Arg
Thr Ala Ala His Glu Asp Ala Ile Ala Val Ala Ser Ala 370 375 380Lys
Asn Gln Thr Val Glu Phe Asp Lys Val Asn Ile Gly Gly Glu Ser385 390
395 400Phe Lys Tyr Arg Asn Ile Gly Ala Phe Phe Asp Lys Ser Lys Ile
Thr 405 410 415Thr Asn Glu Asp Gly Thr Lys Ala Pro Ser Lys Leu Lys
Phe Val Tyr 420 425 430Ile Gly Lys Gly Gln Asp Gln Asp Leu Ile Gly
Leu Asp Leu Arg Gly 435 440 445Lys Ile Ala Val Met Asp Arg Ile Tyr
Thr Lys Asp Leu Lys Asn Ala 450 455 460Phe Lys Lys Ala Met Asp Lys
Gly Ala Arg Ala Ile Met Val Val Asn465 470 475 480Thr Val Asn Tyr
Tyr Asn Arg Asp Asn Trp Thr Glu Leu Pro Ala Met 485 490 495Gly Tyr
Glu Ala Asp Glu Gly Thr Lys Ser Gln Val Phe Ser Ile Ser 500 505
510Gly Asp Asp Gly Val Lys Leu Trp Asn Met Ile Asn Pro Asp Lys Lys
515 520 525Thr Glu Val Lys Arg Asn Asn Lys Glu Asp Phe Lys Asp Lys
Leu Glu 530 535 540Gln Tyr Tyr Pro Ile Asp Met Glu Ser Phe Asn Ser
Asn Lys Pro Asn545 550 555 560Val Gly Asp Glu Lys Glu Ile Asp Phe
Lys Phe Ala Pro Asp Thr Asp 565 570 575Lys Glu Leu Tyr Lys Glu Asp
Ile Ile Val Pro Ala Gly Ser Thr Ser 580 585 590Trp Gly Pro Arg Ile
Asp Leu Leu Leu Lys Pro Asp Val Ser Ala Pro 595 600 605Gly Lys Asn
Ile Lys Ser Thr Leu Asn Val Ile Asn Gly Lys Ser Thr 610 615 620Tyr
Gly Tyr Met Ser Gly Thr Ser Met Ala Thr Pro Ile Val Ala Ala625 630
635 640Ser Thr Val Leu Ile Arg Pro Lys Leu Lys Glu Met Leu Glu Arg
Pro 645 650 655Val Leu Lys Asn Leu Lys Gly Asp Asp Lys Ile Asp Leu
Thr Ser Leu 660 665 670Thr Lys Ile Ala Leu Gln Asn Thr Ala Arg Pro
Met Met Asp Ala Thr 675 680 685Ser Trp Lys Glu Lys Ser Gln Tyr Phe
Ala Ser Pro Arg Gln Gln Gly 690 695 700Ala Gly Leu Ile Asn Val Ala
Asn Ala Leu Arg Asn Glu Val Val Ala705 710 715 720Thr Phe Lys Asn
Thr Asp Ser Lys Gly Leu Val Asn Ser Tyr Gly Ser 725 730 735Ile Ser
Leu Lys Glu Ile Lys Gly Asp Lys Lys Tyr Phe Thr Ile Lys 740 745
750Leu His Asn Thr Ser Asn Arg Pro Leu Thr Phe Lys Val Ser Ala Ser
755 760 765Ala Ile Thr Thr Asp Ser Leu Thr Asp Arg Leu Lys Leu Asp
Glu Thr 770 775 780Tyr Lys Asp Glu Lys Ser Pro Asp Gly Lys Gln Ile
Val Pro Glu Ile785 790 795 800His Pro Glu Lys Val Lys Gly Ala Asn
Ile Thr Phe Glu His Asp Thr 805 810 815Phe Thr Ile Gly Ala Asn Ser
Ser Phe Asp Leu Asn Ala Val Ile Asn 820 825 830Val Gly Glu Ala Lys
Asn Lys Asn Lys Phe Val Glu Ser Phe Ile His 835 840 845Phe Glu Ser
Val Glu Ala Met Glu Ala Leu Asn Ser Ser Gly Lys Lys 850 855 860Ile
Asn Phe Gln Pro Ser Leu Ser Met Pro Leu Met Gly Phe Ala Gly865 870
875 880Asn Trp Asn His Glu Pro Ile Leu Asp Lys Trp Ala Trp Glu Glu
Gly 885 890 895Ser Arg Ser Lys Thr Leu Gly Gly Tyr Asp Asp Asp Gly
Lys Pro Lys 900 905 910Ile Pro Gly Thr Leu Asn Lys Gly Ile Gly Gly
Glu His Gly Ile Asp 915 920 925Lys Phe Asn Pro Ala Gly Val Ile Gln
Asn Arg Lys Asp Lys Asn Thr 930 935 940Thr Ser Leu Asp Gln Asn Pro
Glu Leu Phe Ala Phe Asn Asn Glu Gly945 950 955 960Ile Asn Ala Pro
Ser Ser Ser Gly Ser Lys Ile Ala Asn Ile Tyr Pro 965 970 975Leu Asp
Ser Asn Gly Asn Pro Gln Asp Ala Gln Leu Glu Arg Gly Leu 980 985
990Thr Pro Ser Pro Leu Val Leu Arg Ser Ala Glu Glu Gly Leu Ile 995
1000 10052171696DNAStreptococcus pneumoniae 217tgtggtcgaa
gttgagactc ctcaatcaat aacaaatcag gagcaagcta ggacagaaaa 60ccaagtagta
gagacagagg aagctccaaa agaagaagca cctaaaacag aagaaagtcc
120aaaggaagaa ccaaaatcgg aggtaaaacc tactgacgac acccttccta
aagtagaaga 180ggggaaagaa gattcagcag aaccagctcc agttgaagaa
gtaggtggag aagttgagtc 240aaaaccagag gaaaaagtag cagttaagcc
agaaagtcaa ccatcagaca aaccagctga 300ggaatcaaaa gttgaacaag
caggtgaacc agtcgcgcca agagaagacg aaaaggcacc 360agtcgagcca
gaaaagcaac cagaagctcc tgaagaagag aaggctgtag aggaaacacc
420gaaacaagaa gagtcaactc cagataccaa ggctgaagaa actgtagaac
caaaagagga 480gactgttaat caatctattg aacaaccaaa agttgaaacg
cctgctgtag aaaaacaaac 540agaaccaaca gaggaaccaa aagttgaaca
agcaggtgaa ccagtcgcgc caagagaaga 600cgaacaggca ccaacggcac
cagttgagcc agaaaagcaa ccagaagttc ctgaagaaga 660gaaggctgta
gaggaaacac cgaaaccaga agataaaata aagggtattg gtactaaaga
720accagttgat aaaagtgagt taaataatca aattgataaa gctagttcag
tttctcctac 780tgattattct acagcaagtt acaatgctct tggacctgtt
ttagaaactg caaaaggtgt 840ctatgcttca gagcctgtaa aacagcctga
ggtaaatagc gagacaaata aacttaaaac 900ggctattgac gctctaaacg
ttgataaaac tgaattaaac aatacgattg cagatgcaaa 960aacaaaggta
aaagaacatt acagtgatag aagttggcaa aacctccaaa ctgaagttac
1020aaaggctgaa aaagttgcag ctaatacaga tgctaaacaa agtgaagtta
acgaagctgt 1080tgaaaaatta actgcaacta ttgaaaaatt ggttgaatta
tctgaaaagc caatattaac 1140attgactagt accgataaga aaatattgga
acgtgaagct gttgctaagt atactctaga 1200aaatcaaaac aaaacaaaaa
tcaaatcaat cacagctgaa ttgaaaaaag gagaagaagt 1260tattaatact
gtagtcctta cagatgacaa ggtaacaaca gaaactataa gcgctgcatt
1320taagaaccta gagtactaca aagaatacac cctatctaca actatgattt
acgacagagg 1380taacggtgaa gaaactgaaa ctctagaaaa tcaaaatatt
caattagatc ttaaaaaagt 1440tgagcttaaa aatattaaac gtacagattt
aatcaaatac gaaaatggaa aagaaactaa 1500tgaatcactg ataacaacta
ttcctgatga taagagcaat tattatttaa aaataacttc 1560aaataatcag
aaaactacat tactagctgt taaaaatata gaagaaacta cggttaacgg
1620aacacctgta tataaagtta cagcaatcgc agacaattta gtctctagaa
ctgctgataa 1680taaatttgaa gaagaa 1696218565PRTStreptococcus
pneumoniae 218Val Val Glu Val Glu Thr Pro Gln Ser Ile Thr Asn Gln
Glu Gln Ala1 5 10 15Arg Thr Glu Asn Gln Val Val Glu Thr Glu Glu Ala
Pro Lys Glu Glu 20 25 30Ala Pro Lys Thr Glu Glu Ser Pro Lys Glu Glu
Pro Lys Ser Glu Val 35 40 45Lys Pro Thr Asp Asp Thr Leu Pro Lys Val
Glu Glu Gly Lys Glu Asp 50 55 60Ser Ala Glu Pro Ala Pro Val Glu Glu
Val Gly Gly Glu Val Glu Ser65 70 75 80Lys Pro Glu Glu Lys Val Ala
Val Lys Pro Glu Ser Gln Pro Ser Asp 85 90 95Lys Pro Ala Glu Glu Ser
Lys Val Glu Gln Ala Gly Glu Pro Val Ala 100 105 110Pro Arg Glu Asp
Glu Lys Ala Pro Val Glu Pro Glu Lys Gln Pro Glu 115 120 125Ala Pro
Glu Glu Glu Lys Ala Val Glu Glu Thr Pro Lys Gln Glu Glu 130 135
140Ser Thr Pro Asp Thr Lys Ala Glu Glu Thr Val Glu Pro Lys Glu
Glu145 150 155 160Thr Val Asn Gln Ser Ile Glu Gln Pro Lys Val Glu
Thr Pro Ala Val 165 170 175Glu Lys Gln Thr Glu Pro Thr Glu Glu Pro
Lys Val Glu Gln Ala Gly 180 185 190Glu Pro Val Ala Pro Arg Glu Asp
Glu Gln Ala Pro Thr Ala Pro Val 195 200 205Glu Pro Glu Lys Gln Pro
Glu Val Pro Glu Glu Glu Lys Ala Val Glu 210 215 220Glu Thr Pro Lys
Pro Glu Asp Lys Ile Lys Gly Ile Gly Thr Lys Glu225 230 235 240Pro
Val Asp Lys Ser Glu Leu Asn Asn Gln Ile Asp Lys Ala Ser Ser 245 250
255Val Ser Pro Thr Asp Tyr Ser Thr Ala Ser Tyr Asn Ala Leu Gly Pro
260 265 270Val Leu Glu Thr Ala Lys Gly Val Tyr Ala Ser Glu Pro Val
Lys Gln 275 280 285Pro Glu Val Asn Ser Glu Thr Asn Lys Leu Lys Thr
Ala Ile Asp Ala 290 295 300Leu Asn Val Asp Lys Thr Glu Leu Asn Asn
Thr Ile Ala Asp Ala Lys305 310 315 320Thr Lys Val Lys Glu His Tyr
Ser Asp Arg Ser Trp Gln Asn Leu Gln 325 330 335Thr Glu Val Thr Lys
Ala Glu Lys Val Ala Ala Asn Thr Asp Ala Lys 340 345 350Gln Ser Glu
Val Asn Glu Ala Val Glu Lys Leu Thr Ala Thr Ile Glu 355 360 365Lys
Leu Val Glu Leu Ser Glu Lys Pro Ile Leu Thr Leu Thr Ser Thr 370 375
380Asp Lys Lys Ile Leu Glu Arg Glu Ala Val Ala Lys Tyr Thr Leu
Glu385 390 395 400Asn Gln Asn Lys Thr Lys Ile Lys Ser Ile Thr Ala
Glu Leu Lys Lys 405 410 415Gly Glu Glu Val Ile Asn Thr Val Val Leu
Thr Asp Asp Lys Val Thr 420 425 430Thr Glu Thr Ile Ser Ala Ala Phe
Lys Asn Leu Glu Tyr Tyr Lys Glu 435 440 445Tyr Thr Leu Ser Thr Thr
Met Ile Tyr Asp Arg Gly Asn Gly Glu Glu 450 455 460Thr Glu Thr Leu
Glu Asn Gln Asn Ile Gln Leu Asp Leu Lys Lys Val465 470 475 480Glu
Leu Lys Asn Ile Lys Arg Thr Asp Leu Ile Lys Tyr Glu Asn Gly 485 490
495Lys Glu Thr Asn Glu Ser Leu Ile Thr Thr Ile Pro Asp Asp Lys Ser
500 505 510Asn Tyr Tyr Leu Lys Ile Thr Ser Asn Asn Gln Lys Thr Thr
Leu Leu 515 520 525Ala Val Lys Asn Ile Glu Glu Thr Thr Val Asn Gly
Thr Pro Val Tyr 530 535 540Lys Val Thr Ala Ile Ala Asp Asn Leu Val
Ser Arg Thr Ala Asp Asn545 550 555 560Lys Phe Glu Glu Glu
5652191879DNAStreptococcus pneumoniae 219aacacctgta tataaagtta
cagcaatcgc agacaattta gtctctagaa ctgctgataa 60taaatttgaa gaagaatacg
ttcactatat tgaaaaacct aaagtccacg aagataatgt 120atattataat
ttcaaagaat tagtggaagc tattcaaaac gatccttcaa aagaatatcg
180tctgggacaa tcaatgagcg ctagaaatgt tgttcctaat ggaaaatcat
atatcactaa 240agaattcaca ggaaaacttt taagttctga aggaaaacaa
tttgctatta ctgaattgga 300acatccatta tttaatgtga taacaaacgc
aacgataaat aatgtgaatt ttgaaaatgt 360agagatagaa cgttctggtc
aagataatat tgcatcatta gccaatacta tgaaaggttc 420ttcagttatt
acaaatgtca aaattacagg cacactttca ggtcgtaata atgttgctgg
480atttgtaaat aatatgaatg atggaactcg tattgaaaat gttgctttct
ttggcaaact 540acactctaca agtggaaatg gctctcatac agggggaatt
gcaggtacaa actatagagg 600aattgttaga aaagcatatg ttgatgctac
tattacagga aacaaaacac gcgccagctt 660gttagttcct aaagtagatt
atggattaac tctagaccat cttattggta caaaagctct 720cctaactgag
tcggttgtaa aaggtaaaat agatgtttca aatccagtag aagttggagc
780aatagcaagt aagacttggc ctgtaggtac ggtaagtaat tctgtcagct
atgctaagat 840tatccgtgga gaggagttat tcggctctaa cgacgttgat
gattctgatt atgctagtgc 900tcatataaaa gatttatatg cggtagaggg
atattcgtca ggtaatagat catttaggaa 960atctaaaaca tttactaaat
taactaaaga acaagctgat gctaaagtta ctactttcaa 1020tattactgct
gataaattag aaagtgatct atctcctctt gcaaaactta atgaagaaaa
1080agcctattct agtattcaag attataacgc tgaatataac caagcctata
aaaatcttga 1140aaaattaata ccattctaca ataaagatta tattgtatat
caaggtaata aattaaataa 1200agaacaccat ctaaatacta aagaagttct
ttctgttacc gcgatgaaca acaatgagtt 1260tatcacaaac ctagatgaag
ctaataaaat tattgttcac tatgcggacg gtacaaaaga 1320ttactttaac
ttgtcttcta gcagtgaagg tttaagtaat gtaaaagaat atactataac
1380tgacttagga attaaatata cacctaatat cgttcaaaaa gataacacta
ctcttgttaa 1440tgatataaaa tctattttag aatcagtaga gcttcagtct
caaacgatgt atcagcatct 1500aaatcgatta ggtgactata gagttaatgc
aatcaaagat ttatatttag aagaaagctt 1560cacagatgtt aaagaaaact
taacaaacct aatcacaaaa ttagttcaaa acgaagaaca 1620tcaactaaat
gattctccag ctgctcgtca aatgattcgt gataaagtcg agaaaaacaa
1680agcagcttta ttactaggtt taacttacct aaatcgttac tatggagtta
aatttggtga 1740tgttaatatt aaagaattaa tgctattcaa accagatttc
tatggtgaaa aagttagcgt 1800attagacaga ttaattgaaa tcggttctaa
agagaacaac attaaaggtt cacgtacatt 1860cgacgcattc ggtcaagta
1879220626PRTStreptococcus pneumoniae 220Thr Pro Val Tyr Lys Val
Thr Ala Ile Ala Asp Asn Leu Val Ser Arg1 5 10 15Thr Ala Asp Asn Lys
Phe Glu Glu Glu Tyr Val His Tyr Ile Glu Lys 20 25 30Pro Lys Val His
Glu Asp Asn Val Tyr Tyr Asn Phe Lys Glu Leu Val 35 40 45Glu Ala Ile
Gln Asn Asp Pro Ser Lys Glu Tyr Arg Leu Gly Gln Ser 50 55 60Met Ser
Ala Arg Asn Val Val Pro Asn Gly Lys Ser Tyr Ile Thr Lys65 70 75
80Glu Phe Thr Gly Lys Leu Leu Ser Ser Glu Gly Lys Gln Phe Ala Ile
85 90 95Thr Glu Leu Glu His Pro Leu Phe Asn Val Ile Thr Asn Ala Thr
Ile 100 105 110Asn Asn Val Asn Phe Glu Asn Val Glu Ile Glu Arg Ser
Gly Gln Asp 115 120 125Asn Ile Ala Ser Leu Ala Asn Thr Met Lys Gly
Ser Ser Val Ile Thr 130 135 140Asn Val Lys Ile Thr Gly Thr Leu Ser
Gly Arg Asn Asn Val Ala Gly145 150 155 160Phe Val Asn Asn Met Asn
Asp Gly Thr Arg Ile Glu Asn Val Ala Phe 165 170 175Phe Gly Lys Leu
His Ser Thr Ser Gly Asn Gly Ser His Thr Gly Gly 180 185 190Ile Ala
Gly Thr Asn Tyr Arg Gly Ile Val Arg Lys Ala Tyr Val Asp 195 200
205Ala Thr Ile Thr Gly Asn Lys Thr Arg Ala Ser Leu Leu Val Pro Lys
210 215 220Val Asp Tyr Gly Leu Thr Leu Asp His Leu Ile Gly Thr Lys
Ala Leu225 230 235 240Leu Thr Glu Ser Val Val Lys Gly Lys Ile Asp
Val Ser Asn Pro Val 245 250 255Glu Val Gly Ala Ile Ala Ser Lys Thr
Trp Pro Val Gly Thr Val Ser 260 265 270Asn Ser Val Ser Tyr Ala Lys
Ile Ile Arg Gly Glu Glu Leu Phe Gly 275 280 285Ser Asn Asp Val Asp
Asp Ser Asp Tyr Ala Ser Ala His Ile Lys Asp 290 295 300Leu Tyr Ala
Val Glu Gly Tyr Ser Ser Gly Asn Arg Ser Phe Arg Lys305 310 315
320Ser Lys Thr Phe Thr Lys Leu Thr Lys Glu Gln Ala Asp Ala Lys Val
325 330 335Thr Thr Phe Asn Ile Thr Ala Asp Lys Leu Glu Ser Asp Leu
Ser Pro 340 345 350Leu Ala Lys Leu Asn Glu Glu Lys Ala Tyr Ser Ser
Ile Gln Asp Tyr 355 360 365Asn Ala Glu Tyr Asn Gln Ala Tyr Lys Asn
Leu Glu Lys Leu Ile Pro 370 375 380Phe Tyr Asn Lys Asp Tyr Ile Val
Tyr Gln Gly Asn Lys Leu Asn Lys385 390 395 400Glu His His Leu Asn
Thr Lys Glu Val Leu Ser Val Thr Ala Met Asn 405 410 415Asn Asn Glu
Phe Ile Thr Asn Leu Asp Glu Ala Asn Lys Ile Ile Val 420
425 430His Tyr Ala Asp Gly Thr Lys Asp Tyr Phe Asn Leu Ser Ser Ser
Ser 435 440 445Glu Gly Leu Ser Asn Val Lys Glu Tyr Thr Ile Thr Asp
Leu Gly Ile 450 455 460Lys Tyr Thr Pro Asn Ile Val Gln Lys Asp Asn
Thr Thr Leu Val Asn465 470 475 480Asp Ile Lys Ser Ile Leu Glu Ser
Val Glu Leu Gln Ser Gln Thr Met 485 490 495Tyr Gln His Leu Asn Arg
Leu Gly Asp Tyr Arg Val Asn Ala Ile Lys 500 505 510Asp Leu Tyr Leu
Glu Glu Ser Phe Thr Asp Val Lys Glu Asn Leu Thr 515 520 525Asn Leu
Ile Thr Lys Leu Val Gln Asn Glu Glu His Gln Leu Asn Asp 530 535
540Ser Pro Ala Ala Arg Gln Met Ile Arg Asp Lys Val Glu Lys Asn
Lys545 550 555 560Ala Ala Leu Leu Leu Gly Leu Thr Tyr Leu Asn Arg
Tyr Tyr Gly Val 565 570 575Lys Phe Gly Asp Val Asn Ile Lys Glu Leu
Met Leu Phe Lys Pro Asp 580 585 590Phe Tyr Gly Glu Lys Val Ser Val
Leu Asp Arg Leu Ile Glu Ile Gly 595 600 605Ser Lys Glu Asn Asn Ile
Lys Gly Ser Arg Thr Phe Asp Ala Phe Gly 610 615 620Gln
Val6252211777DNAStreptococcus pneumoniae 221attagacaga ttaattgaaa
tcggttctaa agagaacaac attaaaggtt cacgtacatt 60cgacgcattc ggtcaagtat
tggctaaata tactaaatca ggtaatttag atgcattttt 120aaattataat
agacaattgt tcacaaatat agacaatatg aacgattggt ttattgatgc
180tacagaagac catgtctaca tcgcagaacg cgcttctgag gtcgaagaaa
ttaaaaattc 240taaacatcgt gcattcgata atttaaaacg aagtcacctt
agaaatacta tactcccact 300actgaatatt gataaagcac atctttattt
aatttcaaat tataatgcaa ttgcctttgg 360tagtgcagag cgattaggta
aaaaatcatt agaagatatt aaagatatcg ttaacaaagc 420tgcagatggt
tatagaaact attatgattt ctggtatcgt ctagcgtctg ataacgttaa
480acaacgacta ctaagagatg ctgttattcc tatttgggaa ggttataacg
ctcctggtgg 540atgggttgaa aaatatggcc gctataatac cgacaaagta
tatactcctc ttagagaatt 600ctttggtcct atggataagt attataatta
taatggaaca ggagcttatg ctgctatata 660tcctaactct gatgatatta
gaactgatgt aaaatatgtt catttagaaa tggttggtga 720atacggtatt
tcagtttaca cacatgaaac aacacacgtc aacgaccgtg cgatttactt
780aggtggcttt ggacaccgtg aaggtactga tgctgaagca tatgctcagg
gtatgctaca 840aactcctgtt actggtagtg gatttgatga gtttggttct
ttaggtatta atatggtatt 900taaacgcaaa aatgatggga atcagtggta
tattacagat ccaaaaactc taaaaacacg 960agaagatatt aatagatata
tgaagggtta taatgacact ttaactcttc ttgatgaaat 1020tgaggctgaa
tctgtgattt ctcaacaaaa taaagattta aatagtgcat ggttcaaaaa
1080aatagataga gaataccgtg ataacaataa attaaatcaa tgggataaaa
ttcgaaatct 1140aagtcaagaa gagaaaaatg aattaaatat tcaatctgtt
aatgatttag ttgatcaaca 1200attaatgact aatcgcaatc caggtaatgg
tatctataaa cccgaagcaa ttagctataa 1260cgatcaatca ccttatgtag
gtgttagaat gatgaccggt atctacggag gtaatactag 1320taaaggtgct
cctggagctg tttcattcaa acataatgct tttagattat ggggttacta
1380cggatacgaa aatgggttct taggttatgc ttcaaataaa tataaacaac
aatctaaaac 1440agatggtgag tctgttctaa gtgatgaata tattatcaag
aaaatatcta acaatacatt 1500taatactatt gaagaattta aaaaagctta
cttcaaagaa gttaaagata aagcaacgaa 1560aggattaaca acattcgaag
taaatggttc ttccgtttca tcatacgatg atttactgac 1620attgtttaaa
gaagctgtta aaaaagatgc cgaaactctt aaacaagaag caaacggtaa
1680taaaacagta tctatgaata atacagttaa attaaaagaa gctgtttata
agaaacttct 1740tcaacaaaca aatagcttta aaacttcaat ctttaaa
1777222592PRTStreptococcus pneumoniae 222Leu Asp Arg Leu Ile Glu
Ile Gly Ser Lys Glu Asn Asn Ile Lys Gly1 5 10 15Ser Arg Thr Phe Asp
Ala Phe Gly Gln Val Leu Ala Lys Tyr Thr Lys 20 25 30Ser Gly Asn Leu
Asp Ala Phe Leu Asn Tyr Asn Arg Gln Leu Phe Thr 35 40 45Asn Ile Asp
Asn Met Asn Asp Trp Phe Ile Asp Ala Thr Glu Asp His 50 55 60Val Tyr
Ile Ala Glu Arg Ala Ser Glu Val Glu Glu Ile Lys Asn Ser65 70 75
80Lys His Arg Ala Phe Asp Asn Leu Lys Arg Ser His Leu Arg Asn Thr
85 90 95Ile Leu Pro Leu Leu Asn Ile Asp Lys Ala His Leu Tyr Leu Ile
Ser 100 105 110Asn Tyr Asn Ala Ile Ala Phe Gly Ser Ala Glu Arg Leu
Gly Lys Lys 115 120 125Ser Leu Glu Asp Ile Lys Asp Ile Val Asn Lys
Ala Ala Asp Gly Tyr 130 135 140Arg Asn Tyr Tyr Asp Phe Trp Tyr Arg
Leu Ala Ser Asp Asn Val Lys145 150 155 160Gln Arg Leu Leu Arg Asp
Ala Val Ile Pro Ile Trp Glu Gly Tyr Asn 165 170 175Ala Pro Gly Gly
Trp Val Glu Lys Tyr Gly Arg Tyr Asn Thr Asp Lys 180 185 190Val Tyr
Thr Pro Leu Arg Glu Phe Phe Gly Pro Met Asp Lys Tyr Tyr 195 200
205Asn Tyr Asn Gly Thr Gly Ala Tyr Ala Ala Ile Tyr Pro Asn Ser Asp
210 215 220Asp Ile Arg Thr Asp Val Lys Tyr Val His Leu Glu Met Val
Gly Glu225 230 235 240Tyr Gly Ile Ser Val Tyr Thr His Glu Thr Thr
His Val Asn Asp Arg 245 250 255Ala Ile Tyr Leu Gly Gly Phe Gly His
Arg Glu Gly Thr Asp Ala Glu 260 265 270Ala Tyr Ala Gln Gly Met Leu
Gln Thr Pro Val Thr Gly Ser Gly Phe 275 280 285Asp Glu Phe Gly Ser
Leu Gly Ile Asn Met Val Phe Lys Arg Lys Asn 290 295 300Asp Gly Asn
Gln Trp Tyr Ile Thr Asp Pro Lys Thr Leu Lys Thr Arg305 310 315
320Glu Asp Ile Asn Arg Tyr Met Lys Gly Tyr Asn Asp Thr Leu Thr Leu
325 330 335Leu Asp Glu Ile Glu Ala Glu Ser Val Ile Ser Gln Gln Asn
Lys Asp 340 345 350Leu Asn Ser Ala Trp Phe Lys Lys Ile Asp Arg Glu
Tyr Arg Asp Asn 355 360 365Asn Lys Leu Asn Gln Trp Asp Lys Ile Arg
Asn Leu Ser Gln Glu Glu 370 375 380Lys Asn Glu Leu Asn Ile Gln Ser
Val Asn Asp Leu Val Asp Gln Gln385 390 395 400Leu Met Thr Asn Arg
Asn Pro Gly Asn Gly Ile Tyr Lys Pro Glu Ala 405 410 415Ile Ser Tyr
Asn Asp Gln Ser Pro Tyr Val Gly Val Arg Met Met Thr 420 425 430Gly
Ile Tyr Gly Gly Asn Thr Ser Lys Gly Ala Pro Gly Ala Val Ser 435 440
445Phe Lys His Asn Ala Phe Arg Leu Trp Gly Tyr Tyr Gly Tyr Glu Asn
450 455 460Gly Phe Leu Gly Tyr Ala Ser Asn Lys Tyr Lys Gln Gln Ser
Lys Thr465 470 475 480Asp Gly Glu Ser Val Leu Ser Asp Glu Tyr Ile
Ile Lys Lys Ile Ser 485 490 495Asn Asn Thr Phe Asn Thr Ile Glu Glu
Phe Lys Lys Ala Tyr Phe Lys 500 505 510Glu Val Lys Asp Lys Ala Thr
Lys Gly Leu Thr Thr Phe Glu Val Asn 515 520 525Gly Ser Ser Val Ser
Ser Tyr Asp Asp Leu Leu Thr Leu Phe Lys Glu 530 535 540Ala Val Lys
Lys Asp Ala Glu Thr Leu Lys Gln Glu Ala Asn Gly Asn545 550 555
560Lys Thr Val Ser Met Asn Asn Thr Val Lys Leu Lys Glu Ala Val Tyr
565 570 575Lys Lys Leu Leu Gln Gln Thr Asn Ser Phe Lys Thr Ser Ile
Phe Lys 580 585 590223460DNAStreptococcus pneumoniae 223taagacagat
gaacggagca aggtgtttga cttttccatt ccctactata ctgcaaaaaa 60taaactcatt
gtcaaaaaat ctgacttgac tacttatcag tctgtaaacg acttggcgca
120gaaaaaggtt ggagcgcaga aaggttcgat tcaagagacg atggcgaaag
atttgctaca 180aaattcttcc ctcgtatctc tgcctaaaaa tgggaattta
atcacagatt taaaatcagg 240acaagtggat gccgttatct ttgaagaacc
tgtttccaag ggatttgtgg aaaataatcc 300tgatttagca atcgcagacc
tcaattttga aaaagagcaa gatgattcct acgcggtagc 360catgaaaaaa
gatagcaaga aattgaagag gcagttcgat aaaaccattc aaaagttgaa
420ggagtctggg gaattagaca aactcattga ggaagcctta
460224153PRTStreptococcus pneumoniae 224Lys Thr Asp Glu Arg Ser Lys
Val Phe Asp Phe Ser Ile Pro Tyr Tyr1 5 10 15Thr Ala Lys Asn Lys Leu
Ile Val Lys Lys Ser Asp Leu Thr Thr Tyr 20 25 30Gln Ser Val Asn Asp
Leu Ala Gln Lys Lys Val Gly Ala Gln Lys Gly 35 40 45Ser Ile Gln Glu
Thr Met Ala Lys Asp Leu Leu Gln Asn Ser Ser Leu 50 55 60Val Ser Leu
Pro Lys Asn Gly Asn Leu Ile Thr Asp Leu Lys Ser Gly65 70 75 80Gln
Val Asp Ala Val Ile Phe Glu Glu Pro Val Ser Lys Gly Phe Val 85 90
95Glu Asn Asn Pro Asp Leu Ala Ile Ala Asp Leu Asn Phe Glu Lys Glu
100 105 110Gln Asp Asp Ser Tyr Ala Val Ala Met Lys Lys Asp Ser Lys
Lys Leu 115 120 125Lys Arg Gln Phe Asp Lys Thr Ile Gln Lys Leu Lys
Glu Ser Gly Glu 130 135 140Leu Asp Lys Leu Ile Glu Glu Ala Leu145
150225751DNAStreptococcus pneumoniae 225ctgtgagaat caagctacac
ccaaagagac tagcgctcaa aagacaatcg tccttgctac 60agctggcgac gtgccaccat
ttgactacga agacaagggc aatctgacag gctttgatat 120cgaagtttta
aaggcagtag atgaaaaact cagcgactac gagattcaat tccaaagaac
180cgcctgggag agcatcttcc caggacttga ttctggtcac tatcaggctg
cggccaataa 240cttgagttac acaaaagagc gtgctgaaaa atacctttac
tcgcttccaa tttccaacaa 300tcccctcgtc cttgtcagca acaagaaaaa
tcctttgact tctcttgacc agatcgctgg 360taaaacaaca caagaggata
ccggaacttc taacgctcaa ttcatcaata actggaatca 420gaaacacact
gataatcccg ctacaattaa tttttctggt gaggatattg gtaaacgaat
480cctagacctt gctaacggag agtttgattt cctagttttt gacaaggtat
ccgttcaaaa 540gattatcaag gaccgtggtt tagacctctc agtcgttgat
ttaccttctg cagatagccc 600cagcaattat atcattttct caagcgacca
aaaagagttt aaagagcaat ttgataaagc 660gctcaaagaa ctctatcaag
acggaaccct tgaaaaactc agcaatacct atctaggtgg 720ttcttacctc
ccagatcaat ctcagttaca a 751226250PRTStreptococcus pneumoniae 226Cys
Glu Asn Gln Ala Thr Pro Lys Glu Thr Ser Ala Gln Lys Thr Ile1 5 10
15Val Leu Ala Thr Ala Gly Asp Val Pro Pro Phe Asp Tyr Glu Asp Lys
20 25 30Gly Asn Leu Thr Gly Phe Asp Ile Glu Val Leu Lys Ala Val Asp
Glu 35 40 45Lys Leu Ser Asp Tyr Glu Ile Gln Phe Gln Arg Thr Ala Trp
Glu Ser 50 55 60Ile Phe Pro Gly Leu Asp Ser Gly His Tyr Gln Ala Ala
Ala Asn Asn65 70 75 80Leu Ser Tyr Thr Lys Glu Arg Ala Glu Lys Tyr
Leu Tyr Ser Leu Pro 85 90 95Ile Ser Asn Asn Pro Leu Val Leu Val Ser
Asn Lys Lys Asn Pro Leu 100 105 110Thr Ser Leu Asp Gln Ile Ala Gly
Lys Thr Thr Gln Glu Asp Thr Gly 115 120 125Thr Ser Asn Ala Gln Phe
Ile Asn Asn Trp Asn Gln Lys His Thr Asp 130 135 140Asn Pro Ala Thr
Ile Asn Phe Ser Gly Glu Asp Ile Gly Lys Arg Ile145 150 155 160Leu
Asp Leu Ala Asn Gly Glu Phe Asp Phe Leu Val Phe Asp Lys Val 165 170
175Ser Val Gln Lys Ile Ile Lys Asp Arg Gly Leu Asp Leu Ser Val Val
180 185 190Asp Leu Pro Ser Ala Asp Ser Pro Ser Asn Tyr Ile Ile Phe
Ser Ser 195 200 205Asp Gln Lys Glu Phe Lys Glu Gln Phe Asp Lys Ala
Leu Lys Glu Leu 210 215 220Tyr Gln Asp Gly Thr Leu Glu Lys Leu Ser
Asn Thr Tyr Leu Gly Gly225 230 235 240Ser Tyr Leu Pro Asp Gln Ser
Gln Leu Gln 245 25022733DNAArtificial sequencePrimer 227gactggatcc
taaaatctac gacaataaaa atc 3322827DNAArtificial sequencePrimer
228ctgagtcgac tggttgtgct ggttgag 2722930DNAArtificial
sequencePrimer 229gtcaggatcc aaattacaat acggactatg
3023028DNAArtificial sequencePrimer 230cagtgtcgac taactctagg
tcggaaac 2823135DNAArtificial sequencePrimer 231gactggatcc
tgagaatcaa gctacaccca aagag 3523231DNAArtificial sequencePrimer
232agtcaagctt ttgtaactga gattgatctg g 3123337DNAArtificial
sequencePrimer 233gactggatcc tggtaaccgc tcttctcgta acgcagc
3723432DNAArtificial sequencePrimer 234agtcaagctt tttcaggaac
ttttacgctt cc 3223545DNAArtificial sequencePrimer 235agtcagatct
tgtggaaatt tgacaggtaa cagcaaaaaa gctgc 4523633DNAArtificial
sequencePrimer 236actgaagctt ttttgttttt caagaattca tcg
3323735DNAArtificial sequencePrimer 237gactggatcc tggtcaagga
actgcttcta aagac 3523832DNAArtificial sequencePrimer 238agtcaagctt
tcacaaattc gttggtgaag cc 3223938DNAArtificial sequencePrimer
239gactggatcc tagctcaggt ggaaacgctg gttcatcc 3824035DNAArtificial
sequencePrimer 240agtcaagctt atcaactttt ccaccttcaa caacc
3524137DNAArtificial sequencePrimer 241gtcaagatct ctccaactat
ggtaaatctg cggatgg 3724242DNAArtificial sequencePrimer
242agtcctgcag atccacatcc gctttcatcg ggttaaagaa gg
4224337DNAArtificial sequencePrimer 243gactggatcc tgggaaaaat
tctagcgaaa ctagtgg 3724437DNAArtificial sequencePrimer
244gtcactgcag ctgtccttct tttacttctt tggttgc 3724540DNAArtificial
sequencePrimer 245gactggatcc tgctagcgga aaaaaagata caacttctgg
4024637DNAArtificial sequencePrimer 246ctgaaagctt ttttgccaat
ccttcagcaa tcttgtc 3724737DNAArtificial sequencePrimer
247gactagatct tggctcaaaa aatacagctt caagtcc 3724835DNAArtificial
sequencePrimer 248agtcctgcag gtttttgttt gcttggtatt ggtcg
3524941DNAArtificial sequencePrimer 249gactggatcc tagtacaaac
tcaagcacta gtcagacaga g 4125034DNAArtificial sequencePrimer
250cagtctgcag tttcaaagct ttttgtatgt cttc 3425137DNAArtificial
sequencePrimer 251gactggatcc tggcaattct ggcggaagta aagatgc
3725236DNAArtificial sequencePrimer 252agtcaagctt gtttcatagc
ttttttgatt gtttcg 3625340DNAArtificial sequencePrimer 253gactggatcc
ttcacaagaa aaaacaaaaa atgaagatgg 4025431DNAArtificial
sequencePrimer 254agtcaagctt atcgacgtag tctccgcctt c
3125538DNAArtificial sequencePrimer 255gactggatcc gaaaggtctg
tggtcaaata atcttacc 3825637DNAArtificial sequencePrimer
256agtcaagctt agagttaaca tggtgcttgc caatagg 3725737DNAArtificial
sequencePrimer 257gactggatcc aaactcagaa aagaaagcag acaatgc
3725836DNAArtificial sequencePrimer 258agtcaagctt ccaaactggt
tgatccaaac catctg 3625936DNAArtificial sequencePrimer 259gactggatcc
ttcgaaaggg tcagaaggtg cagacc 3626036DNAArtificial sequencePrimer
260agtcaagctt ctgtaggctt ggtgtgcccc agttgc 3626133DNAArtificial
sequencePrimer 261ctgaggatcc ggggatggca gcttttaaaa atc
3326231DNAArtificial sequencePrimer 262cagtaagctt gtttacccat
tcaccattac c 3126329DNAArtificial sequencePrimer 263cagtggatcc
agacgagcaa aaaattaag 2926428DNAArtificial sequencePrimer
264tcagaagctt gtttacccat tcaccatt 2826535DNAArtificial
sequencePrimer 265gactggatcc ctgtggtgag gaagaaacta aaaag
3526638DNAArtificial sequencePrimer 266ctgagtcgac aatattctgt
aggaatgctt cgaatttg 3826738DNAArtificial sequencePrimer
267ctgaggatcc gacttttaac aataaaacta ttgaagag 3826833DNAArtificial
sequencePrimer 268gtcactgcag gttgtcacct ccaaaaatca cgg
3326937DNAArtificial sequencePrimer 269gactggatcc ctttacaggt
aaacaactac aagtcgg 3727032DNAArtificial sequencePrimer
270cagtaagctt ttcgaagttt ggctcagaat tg 3227132DNAArtificial
sequencePrimer 271gactggatcc ccaggctgat acaagtatcg ca
3227231DNAArtificial sequencePrimer 272cagtaagctt atctgcagta
tggctagatg g 3127337DNAArtificial sequencePrimer 273gactggatcc
gtctgtatca tttgaaaaca aagaaac 3727432DNAArtificial sequencePrimer
274cagtctgcag ttttactgtt gctgtgcttg tg 3227539DNAArtificial
sequencePrimer 275actgagatct tggtcaaaag gaaagtcaga caggaaagg
3927641DNAArtificial sequencePrimer 276cagtaagctt attcctgagc
ttttttgata aaggttgcgc a 4127740DNAArtificial sequencePrimer
277actgggatcc gaaggataga tatattttag catttgagac 4027835DNAArtificial
sequencePrimer 278agtcaagctt ccatggtatc aaaggcaaga cttgg
3527934DNAArtificial sequencePrimer 279gtcaggatcc ggtagttaaa
gttggtatta acgg 3428036DNAArtificial sequencePrimer 280agtcaagctt
gcaatttttg cgaagtattc caagag 3628137DNAArtificial sequencePrimer
281agtcggatcc ttcttacgag ttgggactgt atcaagc 3728240DNAArtificial
sequencePrimer 282agtcaagctt gtttattttt tccttactta cagatgaagg
4028337DNAArtificial sequencePrimer 283agtcggatcc tactgagatg
catcataatc taggagc 3728437DNAArtificial sequencePrimer
284tcagctcgag ttctttgaca tctccatcat aagtcgc 3728535DNAArtificial
sequencePrimer 285gactggatcc ggttttgaga aagtatttgc agggg
3528639DNAArtificial sequencePrimer 286cagtaagctt ggattttttc
atggatgcaa tttttttgg 3928743DNAArtificial sequencePrimer
287gactggatcc gacaacattt actatccata cagtagagtc agc
4328840DNAArtificial sequencePrimer 288gactaagctt ggcataaggt
tgcaattctg gattaattgg 4028930DNAArtificial sequencePrimer
289gactggatcc ggctaaggaa agagtggatg 3029037DNAArtificial
sequencePrimer 290gactaagctt ttcattttta aattgactat gcgcccg
3729136DNAArtificial sequencePrimer 291gactggatcc ttgttcctat
gaacttggtc gtcacc 3629235DNAArtificial sequencePrimer 292catgaagctt
atcctggatt tttccaagta aatct 3529334DNAArtificial sequencePrimer
293gactggatcc ttataagggt gaattagaaa aagg 3429433DNAArtificial
sequencePrimer 294gactaagctt cttattagga ttgttagtag ttg
3329537DNAArtificial sequencePrimer 295gactggatcc gaatgttcag
gctcaagaaa gttcagg 3729636DNAArtificial sequencePrimer
296gactaagctt ttcccctgat ggagcaaagt aatacc 3629740DNAArtificial
sequencePrimer 297gactggatcc cttgggtgta acccatatcc agctccttcc
4029834DNAArtificial sequencePrimer 298gactgtcgac ttcagcttgt
ttatctgggg ttgc 3429938DNAArtificial sequencePrimer 299gactggatcc
tagtgatggt acttggcaag gaaaacag 3830035DNAArtificial sequencePrimer
300actgctgcag atctttgcca cctagcttct cattg 3530140DNAArtificial
sequencePrimer 301gtcaggatcc tgggattcaa tatgtcagag atgatactag
4030235DNAArtificial sequencePrimer 302ctagaagctt acgcacccat
tcaccattat cattg 3530335DNAArtificial sequencePrimer 303gtcaggatcc
ggataataga gaagcattaa aaacc 3530436DNAArtificial sequencePrimer
304agtcaagctt gacaaaatct tgaaactcct ctggtc 3630535DNAArtificial
sequencePrimer 305gtcaggatcc agattttgtc gaggagtgtc atacc
3530636DNAArtificial sequencePrimer 306agtcaagctt tcccttttta
cccttacgaa tccagg 3630743DNAArtificial sequencePrimer 307gactggatcc
atctgtagtt tatgcggatg aaacacttat tac 4330834DNAArtificial
sequencePrimer 308gactgtcgac gctttggtag agatagaagt catg
3430938DNAArtificial sequencePrimer 309gactggatcc ttactttggt
atcgtagata cagccggc 3831037DNAArtificial sequencePrimer
310agtcaagctt tgttaattgc gtaccttcta agcgacc 3731137DNAArtificial
sequencePrimer 311gactggatcc agctaaggtt gcatgggatg cgattcg
3731234DNAArtificial sequencePrimer 312gactgtcgac ctgggcttta
ttagtttgac tagc 3431333DNAArtificial sequencePrimer 313cagtggatcc
ctatcactat gtaaataaag aga 3331430DNAArtificial sequencePrimer
314actgaagctt ttctgtccct gtttgaggca 3031534DNAArtificial
sequencePrimer 315cagtggatcc tgagactcct caatcaataa caaa
3431634DNAArtificial sequencePrimer 316acgtaagctt ataatcagta
ggagaaactg aact 3431730DNAArtificial sequencePrimer 317cagtggatcc
ggatgctcaa gaaactgcgg 3031831DNAArtificial sequencePrimer
318gactaagctt ttgcctctca ttcttgcttc c 3131929DNAArtificial
sequencePrimer 319cagtggatcc cgacaaaggt gagactgag
2932036DNAArtificial sequencePrimer 320acgtaagctt atttcttaat
tcaagtgttt tctctg 3632134DNAArtificial sequencePrimer 321gactggatcc
aaatcaattg gtagcacaag atcc 3432229DNAArtificial sequencePrimer
322cagtgtcgac attaggagcc actggtctc 2932331DNAArtificial
sequencePrimer 323cagtggatcc caaacagtca gcttcaggaa c
3132430DNAArtificial sequencePrimer 324gactctgcag tttaatcttg
tcccaggtgg 3032532DNAArtificial sequencePrimer 325gactggatcc
attcgatgat gcggatgaaa ag 3232633DNAArtificial sequencePrimer
326gactaagctt catttgtctt tgggtatttc gca 3332730DNAArtificial
sequencePrimer 327cagtggatcc ggagagtcga tcaaaagtag
3032828DNAArtificial sequencePrimer 328gtcactgcag ttgctcgtct
cgaggttc 2832932DNAArtificial sequencePrimer 329cagtggatcc
atggacaaca ggaaactggg ac 3233033DNAArtificial sequencePrimer
330cagtaagctt attagcttct gtacctgtgt ttg 3333141DNAArtificial
sequencePrimer 331gactggatcc cgatgggctc aatccaaccc caggtcaagt c
4133240DNAArtificial sequencePrimer 332gactctgcag catagcttta
tcctctgaca tcatcgtatc 4033334DNAArtificial sequencePrimer
333gactggatcc ttccaatcaa aaacaggcag atgg 3433430DNAArtificial
sequencePrimer 334gactaagctt gagtcccata gtccaaggca
3033538DNAArtificial sequencePrimer 335agtcggatcc tatcacagga
tcgaacggta agacaacc 3833634DNAArtificial sequencePrimer
336actggtcgac ttcttttaac tccgctactg tgtc 3433738DNAArtificial
sequencePrimer 337cagtggatcc aagttcatcg aagatggttg ggaagtcc
3833832DNAArtificial sequencePrimer 338gatcgtcgac ccgctcccac
atgctcaacc tt 3233937DNAArtificial sequencePrimer 339tgacggatcc
atcgctagct agtgaaatgc aagaaag 3734037DNAArtificial sequencePrimer
340tgacaagctt attcgttttt gaactagttg ctttcgt 3734137DNAArtificial
sequencePrimer 341gactggatcc gcaccagatg gggcacaagg ttcaggg
3734235DNAArtificial sequencePrimer 342tgacaagctt aacttgtaac
gaacagttca atctg 3534336DNAArtificial sequencePrimer 343gactagatct
ttttaaccca actgttggta ctttcc 3634434DNAArtificial sequencePrimer
344tgacaagctt gttaggtgtt acattttgac cgtc 3434535DNAArtificial
sequencePrimer 345actgagatct ttttaaccca actgttggta ctttc
3534637DNAArtificial sequencePrimer 346gactaagctt tctacgataa
cgatcatttt ctttacc 3734738DNAArtificial sequencePrimer
347gactgtcgac tcgtagatat ttaagtctaa gtgaagcg 3834834DNAArtificial
sequencePrimer 348agtcaagctt gttaggtgtt acattttgca agtc
3434932DNAArtificial sequencePrimer 349gactggatcc ctttggtttt
gaaggaagta ag 3235037DNAArtificial sequencePrimer 350tgacctgcag
acgatttttg aaaaatggag gtgtatc 3735131DNAArtificial sequencePrimer
351cagtggatcc ctactacctc tcgagagaaa g 3135232DNAArtificial
sequencePrimer 352actgaagctt ttcgcttttt actcgtttga ca
3235342DNAArtificial sequencePrimer 353cagtggatcc taaggtcaaa
agtcagaccg ctaagaaagt gc 4235438DNAArtificial sequencePrimer
354cagtaagctt tagggtatcc aaatactggt tgttgatg 3835536DNAArtificial
sequencePrimer 355tgacagatct tgacgggtct caggatcaga ctcagg
3635636DNAArtificial sequencePrimer 356tgacaagctt caaagacatc
cacctcttga cctttg 3635738DNAArtificial sequencePrimer 357gactggatcc
tagaggcttt gccaaatggt gggaaggg 3835840DNAArtificial sequencePrimer
358gtcagtcgac ttgttgtaac acttttcgag gtttggtacc 4035933DNAArtificial
sequencePrimer 359cagtggatcc tcaaaaagag aaggaaaact tgg
3336034DNAArtificial sequencePrimer 360cagtctgcag tttcttcaac
aaaccttgtt cttg 3436131DNAArtificial sequencePrimer 361cagtggatcc
acgttctatt gaggaccact t 3136234DNAArtificial sequencePrimer
362cagtaagctt ttccttctca gtcaattctt ttcc 3436335DNAArtificial
sequencePrimer 363gactggatcc cgctcaaaat accagaggtg ttcag
3536436DNAArtificial sequencePrimer 364gactaagctt agtaccatgg
gtgtgacagg tttgaa 3636535DNAArtificial sequencePrimer 365ctgaggatcc
aattgtacaa ttagaaaaag atagc 3536634DNAArtificial sequencePrimer
366tgacaagctt gcgttgacta ggttctgcaa tgcc 3436740DNAArtificial
sequencePrimer 367gactggatcc tctgaccaag caaaaagaag cagtcaatga
4036834DNAArtificial sequencePrimer 368tcagcagctg atcattgact
ttacgatttg ctcc 3436941DNAArtificial sequencePrimer 369gactggatcc
gtccggctct gtccagtcca ctttttcagc g 4137033DNAArtificial
sequencePrimer 370tcagaagctt attttttgtt tccttaatgc gtt
3337139DNAArtificial sequencePrimer 371gactggatcc gggacaaatt
caaaaaaata ggcaagagg 3937234DNAArtificial sequencePrimer
372gtcaaagctt tggctctttg attgccaaca actg 3437339DNAArtificial
sequencePrimer 373gactggatcc tcgctaccag caacaaagcg agcaaaagg
3937432DNAArtificial sequencePrimer 374gactaagctt acttttttct
ttttccacac ga 3237539DNAArtificial sequencePrimer 375cagtggatcc
gaaccgacaa gtcgcccact atcaagact 3937633DNAArtificial sequencePrimer
376ctgaaagctt tgaattctct ttcttttcag gct 3337736DNAArtificial
sequencePrimer 377tcgaggatcc ggttgtcggc tggcaatata tcccgt
3637837DNAArtificial sequencePrimer 378cagtaagctt ccgaacccat
tcgccattat agttgac 3737935DNAArtificial sequencePrimer
379agtcggatcc ggccaaatca gaatgggtag aagac 3538034DNAArtificial
sequencePrimer 380tgacctgcag cttctcattg attttcatca tcac
3438135DNAArtificial sequencePrimer 381gactggatcc atttgcagat
gattctgaag gatgg 3538238DNAArtificial sequencePrimer 382tcagctgcag
cttaacccat tcaccattct agtttaag 3838337DNAArtificial sequencePrimer
383gactggatcc tgtcgctgca aatgaaactg aagtagc 3738434DNAArtificial
sequencePrimer 384gactaagctt ataccaaacg ctgacatcta cgcg
3438537DNAArtificial sequencePrimer 385agtcagatct tacgtctcag
cctacttttg taagagc 3738634DNAArtificial sequencePrimer
386gactaagctt aacccattca ccattggcat tgac 3438741DNAArtificial
sequencePrimer 387cagtggatcc tggacaggtg aaaggtcatg ctacatttgt g
4138833DNAArtificial sequencePrimer 388gactaagctt caaccattga
gaccttgcaa cac 3338941DNAArtificial sequencePrimer 389gtcaggatcc
gattgctcct ttgaaggatt tgagagaaac c 4139041DNAArtificial
sequencePrimer 390gactaagctt cgatcaaaga taagataaat atatataaag t
4139147DNAArtificial sequencePrimer 391gactggatcc taggtcatat
gggacttttt ttctacaaca aaatagg 4739237DNAArtificial sequencePrimer
392tgacaagctt atctatcagc tcatttaatc gtttttg 3739335DNAArtificial
sequencePrimer 393ctgaggatcc caacgttgag aattatttgc gaatg
3539431DNAArtificial sequencePrimer 394tgacaagctt gagtctacaa
aagtaatgta c 3139535DNAArtificial sequencePrimer 395gtcaggatcc
ctactatcaa tcaagttctt cagcc 3539637DNAArtificial sequencePrimer
396tgacaagctt gactgaggct tggaccagat tgaaaag 3739736DNAArtificial
sequencePrimer 397gactggatcc gacaaaaaca ttaaaacgtc ctgagg
3639834DNAArtificial sequencePrimer 398gactaagctt agcacgaact
gtgacgctgg ttcc 3439935DNAArtificial sequencePrimer 399gactggatcc
ttctcaggag acctttaaaa atatc 3540031DNAArtificial sequencePrimer
400gactaagctt gttggccatc ttgtacatac c 3140131DNAArtificial
sequencePrimer 401gactggatcc agtaaatgcg caatcaaatt c
3140237DNAArtificial sequencePrimer 402agtcctgcag gtatttagcc
caataatcta taaagct 3740332DNAArtificial sequencePrimer
403cagtggatcc ttaccgcgtt catcaagatg tc 3240432DNAArtificial
sequencePrimer 404gactaagctt gccagatgtt gaaaagagag tg
3240540DNAArtificial sequencePrimer 405gactggatcc gtggatgggc
tttaactatc ttcgtattcg 4040633DNAArtificial sequencePrimer
406agtcaagctt gctagtcttc actttccctt tcc 3340734DNAArtificial
sequencePrimer 407gactgtcgac actaaaccag catcgttcgc agga
3440835DNAArtificial sequencePrimer 408ctgactgcag cttcttgaag
aaataatgat tgtgg 3540932DNAArtificial sequencePrimer 409cagtggatcc
tgactacctt gaaatcccac tt 3241039DNAArtificial sequencePrimer
410cagtaagctt ttttttaagg ttgtagaatg atttcaatc 3941135DNAArtificial
sequencePrimer 411cagtgtcgac tcgtatcttt ttttggagca atgtt
3541233DNAArtificial sequencePrimer 412gactaagctt aaatgttccg
atacgggtga ttg 3341333DNAArtificial sequencePrimer 413cagtggatcc
ggactctctc aaagatgtga aag 3341434DNAArtificial sequencePrimer
414gactaagctt cttgagtttg tcaaggattg cttt 3441538DNAArtificial
sequencePrimer 415cagtggatcc caagaaatcc tatcatctct tccagaag
3841633DNAArtificial sequencePrimer 416gactaagctt ttcagaacta
aaagccgcag ctt 3341730DNAArtificial sequencePrimer 417gactggatcc
acgaaatgca gggcagacag 3041836DNAArtificial sequencePrimer
418cagtaagctt atcaacataa tctagtaaat aagcgt 3641936DNAArtificial
sequencePrimer 419cagtggatcc tgtatagttt ttagcgcttg ttcttc
3642036DNAArtificial sequencePrimer 420gtcaaagctt tgatagagtg
tcataatctt ctttag 3642132DNAArtificial sequencePrimer 421gactggatcc
gtgtgtcgag catattctga ag 3242237DNAArtificial sequencePrimer
422cagtaagctt acttttacca tttctttgtt ctgcatc 3742338DNAArtificial
sequencePrimer 423gactgtcgac gtgtttggat agcattcaga atcagacg
3842432DNAArtificial sequencePrimer 424cagtaagctt cggaagtaaa
gacaattttt cc 3242537DNAArtificial sequencePrimer 425cagtggatcc
gtgcctagat agtattatta ctcaaac 3742634DNAArtificial sequencePrimer
426gactaagctt tttgcttatt tctctcaatt tttc 3442736DNAArtificial
sequencePrimer 427cagtggatcc cattcagaag cagacctatc aaaatc
3642843DNAArtificial sequencePrimer 428actgaagctt atgtaatttt
ttagattttt caatattttt cag 4342935DNAArtificial sequencePrimer
429agtcggatcc taaggctgat aatcgtgttc aaatg 3543031DNAArtificial
sequencePrimer 430gactaagctt aaaattagat agacgttgag t
3143135DNAArtificial sequencePrimer 431agtcggatcc ctgtggcaat
cagtcagctg cttcc 3543240DNAArtificial sequencePrimer 432gactgtcgac
tttaatcttg tcccaggtgg ttaatttgcc 4043338DNAArtificial
sequencePrimer 433actggtcgac ttgtcaacaa caacatgcta cttctgag
3843435DNAArtificial sequencePrimer 434gactctgcag aagtttaacc
cacttatcat tatcc 3543539DNAArtificial sequencePrimer 435actgggatcc
ttgttcaggc aagtccgtga ctagtgaac 3943633DNAArtificial sequencePrimer
436gactaagctt ggctaattcc ttcaaagttt gca 3343739DNAArtificial
sequencePrimer 437agtcggatcc ctcgcaaatt gaaaaggcgg cagttagcc
3943835DNAArtificial sequencePrimer 438gactaagctt gtaaataagc
gtaccttttt cttcc 3543938DNAArtificial sequencePrimer 439tcagggatcc
ttgtcagtca ggttctaatg gttctcag 3844032DNAArtificial sequencePrimer
440agtcaagctt ggcattggcg tcgccgtcct tc 3244138DNAArtificial
sequencePrimer 441gactggatcc ggaaacttca caggatttta aagagaag
3844234DNAArtificial sequencePrimer 442gactgtcgac aatcaatcct
tcttctgcac ttct 3444337DNAArtificial sequencePrimer 443cagtggatcc
tgtggtcgaa gttgagactc ctcaatc 3744431DNAArtificial sequencePrimer
444gactaagctt ttcttcaaat ttattatcag c
3144539DNAArtificial sequencePrimer 445agtcggatcc aacacctgta
tataaagtta cagcaatcg 3944637DNAArtificial sequencePrimer
446gactgtcgac tacttgaccg aatgcgtcga atgtacg 3744734DNAArtificial
sequencePrimer 447ctgaggatcc attagacaga ttaattgaaa tcgg
3444834DNAArtificial sequencePrimer 448gactgtcgac tttaaagatt
gaagttttaa agct 3444935DNAArtificial sequencePrimer 449tgacggatcc
taagacagat gaacggagca aggtg 3545035DNAArtificial sequencePrimer
450ctgaaagctt taaggcttcc tcaatgagtt tgtct 3545133DNAArtificial
sequencePrimer 451gactggatcc ctgtgagaat caagctacac cca
3345234DNAArtificial sequencePrimer 452ctgaaagctt ttgtaactga
gattgatctg ggag 344534PRTArtificial sequenceLipoprotein cleavage
consensus sequence 453Leu Xaa Xaa Cys14546PRTArtificial
sequenceHighly conserved sequence from anchored surface proteins
from gram-positive bacteria 454Leu Pro Xaa Thr Gly Xaa1 5
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