U.S. patent application number 12/694441 was filed with the patent office on 2010-05-27 for heterocycle-substituted, n-phenyl-phthalamide derivatives, related compounds and their use as insecticides.
This patent application is currently assigned to BAYER CROPSCIENCE AG. Invention is credited to Rudiger Fischer, Takuya Gombuchi, Tetsuya Murata, Norihiko Nakakura, Yuichi Otsu, Katsuhiko Shibuya, Eiichi Shimojo, Katsuaki Wada, Yasushi Yoneta.
Application Number | 20100130743 12/694441 |
Document ID | / |
Family ID | 34963925 |
Filed Date | 2010-05-27 |
United States Patent
Application |
20100130743 |
Kind Code |
A1 |
Wada; Katsuaki ; et
al. |
May 27, 2010 |
HETEROCYCLE-SUBSTITUTED, N-PHENYL-PHTHALAMIDE DERIVATIVES, RELATED
COMPOUNDS AND THEIR USE AS INSECTICIDES
Abstract
Novel benzenedicarboxamides of the formula (I) wherein X
represents hydrogen, halogen atom, nitro,
C.sub.1-6alkylsulfonyloxy, C.sub.1-6alkylsulfinyl,
C.sub.1-6alkylsulfenyl or C.sub.1-6alkylsulfonyl, R.sup.1
represents C.sub.1-6alkyl, C.sub.1-6alkylthio-C.sub.1-6alkyl,
C.sub.1-6alkylsulfinyl-C.sub.1-6alkyl or C.sub.1-6
alkylsulfonyl-C.sub.1-6alkyl, Y represents halogen or
C.sub.1-6alkyl, m represents 0 or 1, A represents O, S, SO,
SO.sub.2, CH.sub.2 or CH(CH.sub.3), and Q represents a 5- or
6-membered heterocyclic group that contains at least one hetero
atom selected from the group consisting of N, O and S and can be
optionally substituted; processes for their preparation, their
intermediates and their use as insecticides. ##STR00001##
Inventors: |
Wada; Katsuaki; (Oyama-shi,
JP) ; Gombuchi; Takuya; (Tsukuba-shi, JP) ;
Yoneta; Yasushi; (Kazo-shi, JP) ; Otsu; Yuichi;
(Oyama-shi, JP) ; Shibuya; Katsuhiko;
(Kawachi-gun, JP) ; Nakakura; Norihiko;
(Kawachi-gun, JP) ; Fischer; Rudiger; (Pulheim,
DE) ; Murata; Tetsuya; (Oyama-shi, JP) ;
Shimojo; Eiichi; (Oyama-shi, JP) |
Correspondence
Address: |
STERNE, KESSLER, GOLDSTEIN & FOX P.L.L.C.
1100 NEW YORK AVENUE, N.W.
WASHINGTON
DC
20005
US
|
Assignee: |
BAYER CROPSCIENCE AG
Monheim
DE
|
Family ID: |
34963925 |
Appl. No.: |
12/694441 |
Filed: |
January 27, 2010 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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10592361 |
May 24, 2007 |
7674807 |
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PCT/EP2005/002130 |
Mar 1, 2005 |
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12694441 |
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Current U.S.
Class: |
544/335 ;
548/263.2; 548/373.1 |
Current CPC
Class: |
C07D 231/18 20130101;
C07D 231/12 20130101; A01N 43/36 20130101; A61P 33/14 20180101;
C07D 233/68 20130101; C07D 249/12 20130101; C07D 233/64 20130101;
C07D 239/30 20130101; A01N 43/653 20130101; C07D 207/333 20130101;
A01N 43/56 20130101; C07D 231/08 20130101; C07D 231/20 20130101;
C07D 249/08 20130101; A01N 43/54 20130101; A01N 43/78 20130101 |
Class at
Publication: |
544/335 ;
548/263.2; 548/373.1 |
International
Class: |
C07D 239/26 20060101
C07D239/26; C07D 249/12 20060101 C07D249/12; C07D 231/12 20060101
C07D231/12 |
Foreign Application Data
Date |
Code |
Application Number |
Mar 12, 2004 |
JP |
2004-70976 |
Aug 12, 2004 |
JP |
2004-235553 |
Dec 20, 2004 |
JP |
2004-367994 |
Claims
1-3. (canceled)
4. A process for the preparation of a compound of formula (I),
##STR00083## wherein X represents hydrogen, halogen, nitro,
C.sub.1-6alkylsulfonyloxy, C.sub.1-6alkylsulfinyl,
C.sub.1-6alkylsulfenyl or C.sub.1-6alkylsulfonyl, R.sup.1
represents C.sub.1-6alkyl, C.sub.1-6alkylthio-C.sub.1-6alkyl,
C.sub.1-6alkylsulfinyl-C.sub.1-6alkyl or
C.sub.1-6alkylsulfonyl-C.sub.1-6alkyl, Y represents halogen or
C.sub.1-6alkyl, m represents 0 or 1, A represents O, S, SO,
SO.sub.2, CH.sub.2 or CH(CH.sub.3), and Q represents a 5-membered
or 6-membered heterocyclic group that contains at least one hetero
atom selected from the group consisting of N, O and S and can be
optionally substituted; comprising (a) reacting a compound of
formula (II) ##STR00084## wherein R.sup.1 and X have the same
definition as above, with a compound of formula (III) ##STR00085##
wherein Y, A, m and Q have the same definition as above, in the
presence of an inert solvent, and optionally in the presence of an
acid catalyst, or (b) reacting a compound of formula (IV)
##STR00086## wherein X, Y, A, m and Q have the same definitions as
above with a compound of formula (V) H.sub.2N--R.sup.1 (V) wherein
R.sup.1 has the same definition as above, in the presence of an
inert solvent, and optionally in the presence of an acid catalyst,
or (c) reacting a compound of formula (VI) ##STR00087## wherein X
and R.sup.1 have the same definitions as above, with a compound of
formula (III), ##STR00088## wherein Y, A, m and Q have the same
definition as above, in the presence of an inert solvent, and
optionally in the presence of an acid catalyst, or (d) reacting a
compound of formula (VII) ##STR00089## wherein X, Y, A, m and Q
have the same definitions as above, with a compound of formula (V),
H.sub.2N--R.sup.1 (V) wherein R.sup.1 has the same definitions as
above, in the presence of an inert solvent, and optionally in the
presence of an acid catalyst, or (e) reacting a compound of formula
(VIII) ##STR00090## wherein X, Y, A, m and Q have the same
definitions as above, with a compound of formula (V),
H.sub.2N--R.sup.1 (V) wherein R.sup.1 has the same definitions as
above, in the presence of an inert solvent, and optionally in the
presence of an acid catalyst, or (f) in case where R.sup.1
represents C.sub.1-6alkylsulfinyl-C.sub.1-6alkyl or
C.sub.1-6alkylsulfonyl-C.sub.1-6alkyl in formula (I): reacting a
compound of formula (If) ##STR00091## wherein R.sup.If represents
C.sub.1-6alkylthio-C.sub.1-6alkyl, and X, Y, A, m and Q have the
same definitions as above, with an oxidizing agent in the presence
of an inert solvent.
5-9. (canceled)
10. A compound of formula (VII) ##STR00092## wherein X represents
hydrogen, halogen, nitro, C.sub.1-6alkylsulfonyloxy,
C.sub.1-6alkylsulfinyl, C.sub.1-6alkylsulfenyl or
C.sub.1-6alkylsulfonyl, Y represents halogen or C.sub.1-6alkyl, A
represents O, S, SO, SO.sub.2, CH.sub.2 or CH(CH.sub.3), m
represents 0 or 1, and Q represents a 5-membered or 6-membered
heterocyclic group that contains at least one hetero atom selected
from the group consisting of N, O and S and can be optionally
substituted.
11. (canceled)
12. A compound of formula (IX) ##STR00093## wherein X represents
hydrogen, halogen, nitro, C.sub.1-6alkylsulfonyloxy,
C.sub.1-6alkylsulfinyl, C.sub.1-6alkylsulfenyl or
C.sub.1-6alkylsulfonyl, Y represents halogen or C.sub.1-6alkyl, A
represents O, S, SO, SO.sub.2, CH.sub.2 or CH(CH.sub.3), m
represents 0 or 1, and Q represents a 5-membered or 6-membered
heterocyclic group that contains at least one hetero atom selected
from the group consisting of N, O and S and can be optionally
substituted.
Description
[0001] The present invention relates to novel
benzenedicarboxamides, processes for the preparation thereof, their
intermediates and their use as insecticides.
[0002] It was already known that phthalamide derivatives are useful
as insecticides [see JP-A 11-240857 (1999), JP-A 2001-64258, JP-A
2001-64268, JP-A 2001-131141, JP-A 2003-40864, WO 01/21576 and WO
03/11028], and also that they show medicinal function [see JP-A
59-163353 (1984)].
[0003] There have now been found novel benzenedicarboxamides of the
formula (I)
##STR00002##
wherein [0004] X represents hydrogen, halogen atom, nitro,
C.sub.1-6alkylsulfonyloxy, C.sub.1-6alkylsulfinyl, sulfenyl or
C.sub.1-6alkylsulfonyl, [0005] R.sup.1 represents C.sub.1-6alkyl,
C.sub.1-6alkylsulfinyl-C.sub.1-6alkyl or C.sub.1-4
alkylsulfonyl-C.sub.1-6alkyl, [0006] Y represents halogen or
C.sub.1-6alkyl, [0007] m represents 0 or 1, [0008] A represents O,
S, SO, SO.sub.2, CH.sub.2 or CH(CH.sub.3), and [0009] Q represents
a 5- or 6-membered heterocyclic group that contains at least one
hetero atom selected from the group consisting of N, O and S and
can be optionally substituted.
[0010] The compounds of the formula (I), according to the
invention, can be obtained by [0011] (a) reacting compounds of the
formula (II)
[0011] ##STR00003## [0012] wherein R.sup.1 and X have the same
definitions as aforementioned, [0013] with compounds of the formula
(III)
[0013] ##STR00004## [0014] wherein Y, A, m and Q have the same
definitions as aforementioned, [0015] in the presence of inert
solvents, and if appropriate in the presence of an acid catalyst,
or [0016] (b) reacting compounds of the formula (IV)
[0016] ##STR00005## [0017] wherein X, Y, A, m and Q have the same
definitions as aforementioned, [0018] with compounds of the formula
(V)
[0018] H.sub.2N--R.sup.1 (V) [0019] wherein R.sup.1 has the same
definitions as aforementioned, [0020] in the presence of inert
solvents, and if appropriate in the presence of an acid catalyst,
or [0021] (c) reacting compounds of the formula (VI)
[0021] ##STR00006## [0022] wherein X and R.sup.1 have the same
definitions as aforementioned, [0023] with the compounds of the
formula (III),
[0023] ##STR00007## [0024] wherein Y, A, m and Q have the same
definitions as aforementioned, [0025] in the presence of inert
solvents, and if appropriate in the presence of an acid catalyst,
or [0026] (d) reacting compounds of the formula (VII)
[0026] ##STR00008## [0027] wherein X, Y, A, m and Q have the same
definitions as aforementioned, [0028] with the compounds of the
formula (V),
[0028] H.sub.2N--R.sup.1 (V) [0029] wherein R.sup.1 has the same
definitions as aforementioned, [0030] in the presence of inert
solvents, and if appropriate in the presence of an acid catalyst,
or [0031] (e) compounds of the formula (VIII)
[0031] ##STR00009## [0032] wherein X, Y, A, in and Q have the same
definitions as aforementioned, [0033] are reacted with the
compounds of the formula (V),
[0033] H.sub.2N--R.sup.1 (V) [0034] wherein R.sup.1 has the same
definitions as aforementioned, [0035] in the presence of inert
solvents, and if appropriate in the presence of an acid catalyst,
or [0036] (f) in the case that R.sup.1 represents
C.sub.1-6alkylsulfinyl-C.sub.1-6alkyl or
C.sub.1-6alkylsulfonyl-C.sub.1-6alkyl in the formula (I), reacting
compounds of the formula (If)
[0036] ##STR00010## [0037] wherein [0038] R.sup.1f represents
C.sub.1-6alkylthio-C.sub.1-6alkyl, and [0039] X, Y, A, in and Q
have the same definitions as aforementioned, [0040] with an
oxidizing agent in the presence of inert solvents.
[0041] According to the present invention, the
benzenedicarboxamides of the formula (I) show a strong insecticidal
action.
[0042] The compounds of the formula (I) are conceptually embraced
in the general formula described in the aforementioned JP-A
11-240857 (1999). But they are not specifically disclosed at all in
it and new compounds. Surprisingly, they show particularly
remarkable insecticidal action compared with similar compounds
described in the known prior art.
[0043] In the present specification:
[0044] "Halogen" represents fluorine, chlorine, bromine and iodine,
and preferably represents fluorine, chlorine and bromine.
[0045] "Alkyl" represents straight chain or branched chain
C.sub.1-12alkyl, for example, methyl, ethyl, n- or iso-propyl, n-,
iso-, sec- or tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl,
n-nonyl, n-decyl, n-undecyl, n-dodecyl, etc. and preferably
represents C.sub.1-6alkyl.
[0046] As each alkyl part in "alkylsulfonyloxy", "alkylsulfenyl",
"alkylthioalkyl", "alkylsulfinylalkyl", "alkylsulfonylalkyl",
"alkoxy", "alkylthio", "alkylsulfinyl", "alkylsulfonyl",
"haloalkyl", "haloalkoxy", "haloalkylthio", "haloalkylsulfinyl",
"haloalkylsulfonyl" and "haloalkylcarbonyl", there can be mentioned
the same as described in the above-mentioned "alkyl" as
examples.
[0047] As each halogen part in "haloalkyl", "haloalkoxy",
"haloalkylthio", "haloalkylsulfinyl", "haloalkylsulfonyl" and
"haloalkylcarbonyl", there can be mentioned the same as described
in the above-mentioned "halogen" as examples.
[0048] "5- or 6-membered heterocyclic group" contains at least one
hetero atom selected from the group consisting of N, O and S, and
preferably represents a heterocyclic group containing "one to three
N atoms", or "one O atom", or "one S atom", or "both one S atom and
one to two N atoms", or "both one O atom and one to two N atoms",
and as specific examples thereof, pyrazolyl, triazolyl,
pyrazolinyl, imidazolyl, thiazolyl, pyrrolyl, furyl, thienyl,
oxadiazolyl and pyrimidinyl, and moreover as most preferable
examples thereof, pyrazolyl, triazolyl, pyrazolinyl, imidazolyl,
thiazolyl, pyrrolyl, oxadiazolyl and pyrimidinyl are
exemplified.
[0049] In the compounds of the formula (I), according to the
invention, the compounds in case that [0050] X represents hydrogen,
fluorine, chlorine, bromine, iodine, nitro, C.sub.1-4
alkylsulfonyloxy, C.sub.1-4alkylsulfinyl, C.sub.1-4 alkylsulfenyl
or C.sub.1-4 alkylsulfonyl, [0051] R.sup.1 represents
C.sub.1-4alkyl, C.sub.1-4alkylthio-C.sub.1-4alkyl,
C.sub.1-4alkylsulfinyl-C.sub.1-4alkyl or
C.sub.1-4alkylsulfonyl-C.sub.1-4alkyl, [0052] Y represents
fluorine, chlorine, bromine or C.sub.1-4alkyl, [0053] m represents
0 or 1, [0054] A represents O, S, SO, SO.sub.2, CH.sub.2 or
CH(CH.sub.3), and [0055] Q represents 5-membered or 6-membered
heterocyclic group that contains at least one hetero atom selected
from a group consisting of N, O and S and can be optionally
substituted by at least one selected from a group consisting of
C.sub.1-6alkyl, C.sub.1-6alkoxy, C.sub.1-6alkylthio,
C.sub.1-6alkylsulfinyl, C.sub.1-6alkylsulfonyl,
C.sub.1-10haloalkoxy, C.sub.1-6haloalkoxy, C.sub.1-6haloalkylthio,
C.sub.1-6haloalkylsulfinyl, C.sub.1-6haloalkylsulfonyl,
C.sub.1-6haloalkylcarbonyl, halogen, oxo and hydroxy group, can be
mentioned as preferable.
[0056] Above all, in the compounds of the formula (I), the
compounds in case that [0057] X represents hydrogen, fluorine,
chlorine, bromine, iodine, nitro, methanesulfonyloxy, C.sub.1-2
alkylsulfenyl or C.sub.1-2 alkylsulfonyl, [0058] R.sup.1 represents
isopropyl, C.sub.1-2alkylthio-C.sub.3-4alkyl,
C.sub.1-2alkylsulfinyl-C.sub.3-4alkyl or
C.sub.1-2alkylsulfonyl-C.sub.3-4alkyl, [0059] Y represents
fluorine, chlorine or methyl, [0060] m represents 0 or 1, [0061] A
represents O, S, SO, SO.sub.2, CH.sub.2 or CH(CH.sub.3), and [0062]
Q represents heterocyclic group, selected from a group consisting
of pyrazolyl, triazolyl, pyrazolinyl, imidazolyl, thiazolyl,
pyrrolyl, oxadiazolyl and pyrimidinyl, that can be optionally
substituted by at least one selected from the group consisting of
C.sub.1-4alkyl, C.sub.1-4alkoxyl, C.sub.1-4alkylthio,
C.sub.1-4alkylsulfinyl, C.sub.1-4alkylsulfonyl, C.sub.1-8haloalkyl,
C.sub.1-4haloalkoxy, C.sub.1-4haloalkylthio,
C.sub.1-4haloalkylsulfinyl, C.sub.1-4haloalkylsulfonyl,
C.sub.1-4haloalkylcarbonyl, fluorine, chlorine, bromine, iodine,
oxo and hydroxy group, are particularly preferable.
[0063] The compounds of the formula (I), according to the present
invention, include stereo isomers (R/S configuration) in case that
the group R.sup.1 has an asymmetric carbon.
[0064] The aforementioned process (a) can be illustrated by the
following reaction scheme in case that, for example,
3-(1,1-dimethyl-2-methylthioethylimino)-4-iodo-3H-isobenzofuran-1-one
and 1-(4-amino-3-methylbenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole
are used as starting materials.
##STR00011##
[0065] The aforementioned preparation process (b) can be
illustrated by the following reaction scheme in case that, for
example,
2-{4-[3,5-bis(trifluoromethyl)pyrazole-1-ylmethyl]-2-methylphenyl}-4-fluo-
roisoindole-1,3-dione and (S)-1-methyl-2-methylthioethylamine are
used as starting materials.
##STR00012##
[0066] The aforementioned preparation process (c) can be
illustrated by the following reaction scheme in case that, for
example, 3-iodo-N-(1,1-dimethyl-2-methylthioethyl)-phthalamic acid
and 2-methyl-4-[1-(3-trifluoromethylpyrazole-1-yl)-ethyl]aniline
are used as starting materials.
##STR00013##
[0067] The aforementioned preparation process (d) can be
illustrated by the following reaction scheme in case that, for
example,
1-[4-(4-iodo-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,5--
bis(trifluoromethyl)-(1,2,4)-triazol and
1-methyl-2-methylthioethylamine are used as starting materials.
##STR00014##
[0068] The aforementioned preparation process (e) can be
illustrated by the following reaction scheme in case that, for
example,
N-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methyl-phenyl}-6--
iodo-phthalamic acid and 1-methyl-2-methylthioethylamine are used
as starting materials.
##STR00015##
[0069] The aforementioned process (f) can be illustrated by the
following reaction scheme in case that, for example,
N.sup.2-(1-methyl-2-methylthioethyl)-3-iodo-N.sup.1-{2-methyl-4-[3,5-bis(-
trifluoromethyl)-1H-pyrazol-1-ylmethyl]phenyl}phthalamide and
m-chloroperbenzoic acid are used as starting materials.
##STR00016##
[0070] The compounds of the formula (II), used as starting
materials in the above-mentioned preparation process (a), are per
se known compounds and can be easily prepared according to the
process described in, for example, JP-A 11-240857 (1999), JP-A
2001-131141.
[0071] As specific examples of the compounds of the formula (Ia),
used as starting materials in the preparation process (a), there
can be mentioned the following: [0072]
3-isopropylimino-3H-isobenzofuran-1-one, [0073]
4-fluoro-3-isopropylimino-3H-isobenzofuran-1-one, [0074]
4-chloro-3-isopropylimino-3H-isobenzofuran-1-one, [0075]
4-bromo-3-isopropylimino-3H-isobenzofuran-1-one, [0076]
4-iodo-3-isopropylimino-3H-isobenzofuran-1-one, [0077]
3-(1-methyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
[0078]
4-fluoro-3-(1-methyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
[0079]
4-chloro-3-(1-methyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-
-1-one, [0080]
4-bromo-3-(1-methyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
[0081]
4-iodo-3-(1-methyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-
-one, [0082]
3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
[0083]
3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-4-fluoro-3H-isobenzof-
uran-1-one, [0084]
4-chloro-3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1--
one, [0085]
4-bromo-3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-o-
ne, [0086]
3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-4-iodo-3H-isobenzo-
furan-1-one, [0087]
3-isopropylimino-1-oxo-1,3-dihydro-isobenzofuran-4-yl
methanesulfonate [0088]
3-(1-methyl-2-methylsulfanyl-ethylimino)-1-oxo-1,3-dihydro-isobenzofuran--
4-yl methanesulfonate [0089]
3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-1-oxo-1,3-dihydro-isobenzofu-
ran-4-yl methanesulfonate and so on.
[0090] The compounds of the formula (III), used as starting
materials in the above-mentioned preparation process (a), which are
partly novel compounds that are not described in the existing
literature yet, can be obtained, for example, by reducing compounds
of the formula (IX)
##STR00017##
wherein Y, A, m and Q have the same definitions as aforementioned,
according to the catalytic hydrogen reduction process, a well-known
process in the field of organic chemistry, with hydrogen in the
presence of a catalytic reduction catalyst, for example, palladium
carbon, Raney nickel, platinum oxide, etc.
[0091] The above-mentioned catalytic hydrogen reduction process can
be conducted in an adequate diluent.
[0092] As examples of the diluent used in that case there can be
mentioned ethers, for example, ethyl ether, methyl ethyl ether,
isopropyl ether, butyl ether, dioxane, tetrahydrofuran (THF), etc.;
alcohols, for example, methanol, ethanol, isopropanol, butanol,
ethylene glycol, etc. and as catalytic reduction catalyst there can
be mentioned, palladium carbon, Raney nickel, platinum oxide,
etc.
[0093] The reaction can be conducted at the temperatures generally
from about 0 to about 100.degree. C., preferably from room
temperature (20.degree. C.) to about 80.degree. C.
[0094] Said reaction can be conducted usually under normal pressure
but can be operated optionally also under elevated pressure.
[0095] For example, a compound of the formula (III) can be obtained
by hydrogenating the compounds of the formula (IX) in a diluent,
for example, ethanol, in the presence of 0.1-10% (w/w) palladium
carbon.
[0096] Also by a reduction reaction using metals etc. instead of
catalytic hydrogen reduction, the compounds of the formula (III)
can be obtained from the compounds of the formula (IX).
[0097] As a reduction process using metals etc., there can be
mentioned, for example, a process of reacting iron powder in acetic
acid, a process of reacting zinc dust under neutral condition
(Organic Syntheses Collective Vol. II, p. 447), a process of
reacting stannic chloride under acidic condition (Organic Syntheses
Collective Vol. II, p. 254), a process of reacting titanium
trichloride under neutral condition, etc.
[0098] The compounds of the formula (IX) are novel compounds and
can be obtained by reacting the compounds of the formula (IX)
wherein A represents other than oxygen atom, for example, compounds
of the formula (X)
##STR00018##
wherein [0099] Y and m have the same definitions as aforementioned,
[0100] A.sup.1 represents S, SO, SO.sub.2, CH.sub.2 or
CH(CH.sub.3), and [0101] M represents chlorine, bromine or
methanesulfonyloxy, with compounds of the formula (XI)
[0101] H-Q (XI)
wherein Q has the same definition as aforementioned.
[0102] The compounds of the formula (X), are well known in the
field of organic chemistry and described in publications, for
example, Chem. Abstr., Vol. 58, 3444e (1963); Bull. Soc. Claim. Fr.
(1934), p. 539-545; J. Chem. Res. Miniprint, Vol. 8 (1987), p.
2133-2139; J. Chem. Soc. B (1967), p. 1154-1158; J. Chem. Soc.
(1961), p. 221-222; J. Amer. Chem. Soc., Vol. 111 (1989), p.
5880-5886; J. Amer. Chem. Soc., Vol. 96 (1974), p. 7770-7781; Can.
J. Chem., Vol. 68 (1990), p. 1450-1455, Tetrahedron Letter, vol. 35
(1994), p. 7391-7394.
[0103] As specific examples of the compounds of the formula (X),
there can be mentioned specifically [0104] 2-methyl-4-nitrobenzyl
chloride, [0105] 3-methyl-4-nitrobenzyl chloride [0106]
4-nitrobenzyl methanesulfonate [0107] 2-methyl-4-nitrobenzyl
methanesulfonate [0108] 3-methyl-4-nitrobenzyl methanesulfonate,
[0109] 4-nitrobenzenesulfenyl chloride, [0110]
4-nitrobenzenesulfinyl chloride, [0111] 4-nitrobenzenesulfonyl
chloride, [0112] 4-nitro-3-methylbenzenesulfonyl chloride, [0113]
3-fluoro-4-nitrobenzyl bromide, [0114] 3-chloro-4-nitrobenzyl
chloride and so on.
[0115] The nitro-substituted benzoic acids and their esters,
starting materials of the compounds of the formula (X), are known
compounds described in, for example, Chem. Ber., Vol. 52 (1919), p.
1083; Bull. Soc. Chim. Fr. (1962), p. 2255-2261; Tetrahedron
(1985), p. 115-118; Chem. Pharm. Bull., Vol. 41 (1993), p. 894-906;
WO 2001/042227.
[0116] The compounds of the formula (XI) include known compounds
and as their specific examples, there can be mentioned: [0117]
3,5-bis(trifluoromethyl)-1H-pyrazole, [0118]
5-difluoromethoxy-3-trifluoromethyl-1H-pyrazole, [0119]
4-pentafluoroethyl-1H-pyrazole, [0120]
5-hexafluoro-n-propyl-1H-pyrazole, [0121]
3,5-bis(trifluoromethyl)-1H-(1,2,4)-triazole, [0122]
5-pentafluoroethyl-3-trifluoromethyl-1H-(1,2,4)-triazole, [0123]
5-difluoromethyl-3-trifluoromethyl-1H-(1,2,4) triazole, [0124]
5-hydroxy-3,5-bis(trifluoromethyl)-1H-4,5-dihydropyrazole, [0125]
2,4-bis(trifluoromethyl)-1H-imidazole, [0126]
3-(2,2,2-trifluoroethyl)-5-trifluoromethyl-1,2-dihydro-(1,3,4)-triazol-2--
one, [0127] 2,5-bis(trifluoromethyl)-(1,3,4)-triazole, [0128]
5-pentafluoroethyl-1H-pyrazole, [0129]
3-pentafluoroethyl-1H-pyrazole, [0130]
4-bromo-3-trifluoromethyl-1H-pyrazole, [0131]
3-trifluoromethyl-1H-pyrazole, [0132]
5-(difluoromethyl)-1,2-dihydro-2-methyl-3H-(1,2,4)-triazol-3-one,
[0133] 4-(trifluoromethyl)-2H-1,2,3-triazole, [0134]
4-iodo-3-pentafluoroethyl-1H-pyrazole, [0135]
3-pentafluoroethyl-4-(1,1,2,2-tetrafluoroethyl)-1H-pyrazole, [0136]
3,4-bis-pentafluoroethyl-1H-pyrazole, [0137]
3,5-diiodo-4-methyl-1H-pyrazole, [0138]
3-Heptafluoropropylsulfanyl-5-trifluoromethyl-1H-(1,2,4)-triazole,
[0139] 3,5-bis(pentafluoroethyl)-1H-(1,2,4)-triazole and so on.
[0140] The above-mentioned reaction of the compounds of the formula
(X) with the compounds of the formula (XI) can be conducted in an
adequate diluent.
[0141] As examples of the diluent used in that case there can be
mentioned, for example, aliphatic, alicyclic and aromatic
hydrocarbons (may be optionally chlorinated), for example, pentane,
hexane, cyclohexane, petroleum ether, ligroine, benzene, toluene,
xylene, dichloromethane, etc.; ethers, for example, ethyl ether,
methyl ethyl ether, isopropyl ether, butyl ether, dioxane,
dimethoxyethane (DME), tetrahydrofuran (THF), diethylene glycol
dimethyl ether (DGM), etc.; ketones, for example, acetone, methyl
ethyl ketone (MEK), methyl isopropyl ketone, methyl isobutyl ketone
(MIBK), etc.; nitriles, for example, acetonitrile, propionitrile,
acrylonitrile, etc.; esters, for example, ethyl acetate, amyl
acetate, etc.; acid amides, for example, dimethylformamide (DMF),
dimethylacetamide (DMA), N-methylpyrrolidone,
1,3-dimethyl-2-imidazolidinone, hexamethyl phosphoric triamide
(HMPA), etc.
[0142] The reaction can be conducted in the presence of an acid
binder and as said acid binder there can be mentioned, for example,
as inorganic base, hydrides, hydroxides, carbonates, bicarbonates,
etc. of alkali metals or alkaline earth metals, for example, sodium
hydride, lithium hydride, sodium hydrogen carbonate, potassium
hydrogen carbonate, sodium carbonate, potassium carbonate, lithium
hydroxide, sodium hydroxide, potassium hydroxide, calcium
hydroxide, etc.; inorganic alkali metal amides, for example,
lithium amide, sodium amide, potassium amide, etc.; as organic
base, alcoholates, tertiary amines, dialkylaminoanilines and
pyridines, for example, triethylamine,
1,1,4,4-tetramethylethylenediamine (TMEDA), N,N-dimethylaniline,
N,N-diethylaniline, pyridine, 4-dimethylaminopyridine (DMAP),
1,4-diazabicyclo[2,2,2]octane (DABCO),
1,8-diazabicyclo[5,4,0]undec-7-ene (DBU), etc.
[0143] The above-mentioned reaction can also be conducted by a
process using a phase transfer catalyst in the presence of a
diluent. As examples of the diluent used in that case there can be
mentioned water; aliphatic, alicyclic and aromatic hydrocarbons
(may be optionally chlorinated), for example, pentane, hexane,
cyclohexane, petroleum ether, ligroine, benzene, toluene, xylene,
etc.; ethers, for example, ethyl ether, methyl ethyl ether,
isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME),
tetrahydrofuran diethylene glycol dimethyl ether (DGM), etc. As
examples of the phase transfer catalyst, quaternary ions, for
example, tetramethylammonium bromide, tetrapropylammonium bromide,
tetrabutylammonium bromide, tetrabutylammonium bissulfate,
tetrabutylammonium iodide, trioctylmethylammonium chloride,
benzyltriethylammonium bromide, butylpyridinium bromide,
heptylpyridinium bromide, benzyltriethylammonium chloride, etc.;
crown ethers, for example, dibenzo-18-crown-6,
dicyclohexyl-18-crown-6, 18-crown-6, etc.; cryptands, for example,
[2.2.2]-cryptate, [2.1.1]-cryptate, [2.2.1]-cryptate,
[2.2.B]-cryptate, [3.2.2]-cryptate, etc.
[0144] The above-mentioned reaction can be conducted in a
substantially wide range of temperature. It is adequate to conduct
it at the temperatures in a range of generally from about 0 to
about 200.degree. C., preferably from room temperature (20.degree.
C.) to about 150.degree. C.
[0145] Although said reaction is conducted desirably under normal
pressure, it can be operated also under elevated pressure or under
reduced pressure.
[0146] In conducting the above-mentioned reaction, the aimed
compounds of the formula (IX) can be obtained, for example, by
reacting 1 mole to a little excess mole amount of the compounds of
the formula (XI) to 1 mole of the compounds of the formula (X) in a
diluent, for example, DMF, in the presence of potassium
carbonate.
[0147] As the compounds of the formula (IX) obtained according to
the above-mentioned process, there can be mentioned, for example,
the corresponding 4-nitrobenzyl derivatives to the 4-aminobenzyl
derivatives of the formula (III) mentioned hereinafter. And, as one
typical example,
1-(3-methyl-4-nitrobenzyl)-3,5-bis-(trifluoromethyl)-1H-pyrazole
can be mentioned.
[0148] Furthermore, in a case where Q represents 2-thiazolyl in the
formula (IX), as a specific example,
2-(3-methyl-4-nitrobenzyl)-4-pentafluoroethyl-thiazole can be
prepared by the following way in which a known compound,
3-methyl-4-niirobenzylcyanide (see J. Chem. Soc., vol. 97 (1910),
p. 2260) is reacted with hydrogen sulfide, and then the product,
3-methyl-4-nitro-benzylthioamide is reacted with a commercial
product, 1-bromo-3,3,4,4,4-pentafluoro-2-butanone and then
cyclized, according to a method described in J. Heterocycl. Chem.,
vol. 28 (1991) p. 907 to 911.
[0149] In a case where Q represents 1,3,4-oxadiazol-2-yl in the
formula (IX), as a specific example,
2-(3-methyl-4-nitrophenyl)-5-trifluoromethyl-1,3,4-oxazole can
easily be obtained, according to a method described in
Heterocycles, (1994), vol. 38, p. 981 to 990, from the
corresponding aldoxime as a starting material which can be prepared
by a method described in Justus Liebigs Ann. Chem., (1927) vol. 45,
p. 166.
[0150] And, as another specific example,
2-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1,3,4-oxazole can
easily be obtained, according to a method described in
Heterocycles, (1994) vol. 38, p. 981 to 990, from the corresponding
3-methyl-4-nitrobenzaldehyde oxime. In the above preparation, the
oxime can be obtained from a known 3-methyl-4-nitrobenzaldehyde
[see J. Chem. Soc. B, (1967) p. 1154 to 1158] as a starting
material, according to methods described in J. Chem. Soc. C, (1969)
p. 986 to 990 and then Tetrahedron Letter, vol. 35 (1994) p. 9099
to 9100.
[0151] In a case where Q represents 2H-1,2,3-triazol-2-yl in the
formula (IX), as a specific example,
2-(3-methyl-4-nitrobenzyl)-2H-4-trifluoromethyl-1,2,3-triazole can
easily be prepared by a reaction of a known 3-methyl-4-nitrobenzyl
chloride with a known 2H-4-trifluoromethyl-1,2,3-triazole described
in J. Chem. Soc., Perkin Transaction 2, vol. 10 (1989) p. 1355 to
1375.
[0152] In a case where Q represents 1H-1,2,4-triazol-1-yl in the
formula (IX), as a specific example,
5-(3-methyl-4-nitrophenylsulfanyl)-1-methyl-3-trifluoromethyl-1H-1,2,4-tr-
iazole can easily be prepared by a reaction of
1-fluoro-3-methyl-4-nitrobenzene with a known
5-mercapto-1-methyl-3-trifluoromethyl-1H-1,2,4-triazole described
in J. Med. Chem., vol. 35 (1992) p. 2103 to 2112, according to the
same preparation as Synthesis Example 47 hereinafter.
[0153] In a case where Q represents 1,2,4-oxazol-3-yl in the
formula (IX), as a specific example,
3-(3-methyl-4-nitrophenyl)-5-trifluoromethyl-1,2,4-oxazole can
easily be obtained from 3-methyl-4-nitrobenzamideoxime, according
to a method described in 3. Org. Chem., vol. 68(2), 2003, p.
605-608. And, 3-methyl-4-nitrobenzamideoxime can be prepared by a
reaction of a commercial 3-methyl-4-nitrobenzonitrile with
hydroxylamine, according to a method described in Chem. Ber., vol.
22 (1889), p. 2428.
[0154] And, as another specific example,
3-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1,2,4-oxazole can
easily be obtained from 2-(3-methyl-4-nitrophenyl)-acetamideoxime
as well, according to a method described in J. Org. Chem., vol.
68(2), 2003, p. 605-608. And,
2-(3-methyl-4-nitrophenyl)-acetamideoxime can be prepared by a
reaction of 3-methyl-4-nitrophenyl-acetonitrile with hydroxylamine,
according to a method described in Chem. Ber., vol. 22 (1889), p.
2428.
[0155] In a case where Q represents 1H-1,2,4-triazol-3-yl in the
formula (IX), as specific examples,
1-methyl-3-(3-methyl-4-nitrophenyl)-5-trifluoromethyl-1H-1,2,4-triazole
can easily be prepared by a reaction of the above
3-(3-methyl-4-nitrophenyl)-5-trifluoromethyl-1,2,4-oxazole with
methylhydrazine, according to a method described in J. Org. Chem.,
vol. 68(2), 2003, p. 605-608, and also
1-methyl-3-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1H-1,2,4-thiazole
can be done by a reaction of the above
3-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1,2,4-oxazole with
methylhydrazine as well.
[0156] The compounds of the formula (IX) can be prepared, besides
the above-mentioned preparation process, also by the process to be
mentioned later in Examples as an alternative.
[0157] As specific examples of the compounds of the formula (III)
there can be mentioned, for example, the following: [0158]
1-(4-amino-3-methylbenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole,
[0159]
1-(4-amino-3-methylbenzyl)-5-difluoromethoxy-3-trifluoromethyl-1H-pyrazol-
e, [0160]
1-(4-amino-3-methylbenzyl)-4-pentafluoroethyl-1H-pyrazole, [0161]
1-(4-amino-3-methylbenzyl)-5-hexafluoro-n-propyl-1H-pyrazole,
[0162]
1-(4-amino-3-methylbenzyl)-3,5-bis(trifluoromethyl)-1H-(1,2,4)-tri-
azole, [0163]
1-(4-amino-3-methylbenzyl)-5-pentafluoroethyl-3-trifluoromethyl-1H-(1,2,4-
)-triazole, [0164]
1-(4-amino-3-methylbenzyl)-5-difluoromethyl-3-trifluoromethyl-1H-(1,2,4)--
triazole, [0165]
4-(4-amino-3-methylbenzyl)-5-difluoromethoxy-1-difluoromethyl-3-trifluoro-
methyl-1H-pyrazole, [0166]
4-(4-amino-3-methylbenzyl)-3-difluoromethoxy-1-difluoromethyl-5-trifluoro-
methyl-1H-pyrazole, [0167]
1-(4-amino-3-methylbenzyl)-5-hydroxy-3,5-bis(trifluoromethyl)-1H-4,5-dihy-
dropyrazole, [0168]
1-(4-amino-3-methylbenzyl)-2,4-bis(trifluoromethyl)-1H-imidazole,
[0169]
4-(4-amino-3-methylbenzyl)-2-(2,2,2-trifluoroethyl)-5-trifluoromethyl-2,4-
-dihydro-3H-(1,2,4)-triazol-3-one, [0170]
2-(4-amino-3-methylbenzyl)-4-(2,2,2-trifluoroethyl)-5-trifluoromethyl-2,4-
-dihydro-3H-(1,2,4)-triazol-3-one, [0171]
1-(4-amino-3-methylbenzyl)-2,5-bis(trifluoromethyl)-1,3,4-triazole,
[0172]
2-(4-amino-3-methylbenzyl)-4,6-bis(trifluoromethyl)-pyrimidine,
[0173]
2-(4-amino-3-methylphenoxy)-4,6-bis(trifluoromethyl)-pyrimidine,
[0174]
1-(4-amino-3-methylphenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole,
[0175] 1-(4-amino-3-methylphenyl)-5-pentafluoroethyl-1H-pyrazole,
[0176] 1-(4-amino-3,7-methylphenyl)-3-pentafluoroethyl-1H-pyrazole,
[0177] 1-(4-amino-3-methylphenyl)-4-pentafluoroethyl-1H-pyrazole,
[0178]
1-(4-amino-3-methylphenyl)-3-methyl-5-trifluoromethyl-1H-pyrazole,
[0179]
1-(4-amino-3-methylphenyl)-5-methyl-3-trifluoromethyl-1H-pyrazole,
[0180]
1-(4-amino-3-methylphenyl)-3-pentafluoroethyl-5-trifluoromethyl-1H-pyrazo-
le, [0181]
1-(4-amino-3-methylphenyl)-4-bromo-3-trifluoromethyl-1H-pyrazol- e,
[0182] 1-(4-amino-3-methylphenyl)-3-trifluoromethyl-1H-pyrazole,
[0183]
1-(4-amino-3-methylphenyl)-5-hydroxy-3-(2,2,2-trifluoroethyl)-5-trifluoro-
methyl-1H-4,5-dihydropyrazole, [0184]
5-(4-amino-3-methylphenyl)-1-(2,2,2-trifluoroethyl)-3-trifluoromethyl-pyr-
azole, [0185]
5-(4-amino-3-methylphenyl)-1-difluoromethyl-3-trifluoromethyl-pyrazole,
[0186]
3-(4-amino-3-methylphenyl)-1-difluoromethyl-3-difluoromethoxy-pyra-
zole, [0187]
1-(4-amino-3-methylbenzyl)-3,4-bis(pentafluoroethyl)-1H-pyrazole,
[0188]
1-(4-amino-3-methylbenzyl)-3,5-bis(pentafluoroethyl)-1H-pyrazole,
[0189]
1-(4-amino-3-methylbenzyl)-3,4-bis(pentafluoropropyl)-1H-pyrazole,
[0190]
1-(4-amino-3-methylbenzyl)-3,5-bis(pentafluoropropyl)-1H-pyrazole,
[0191]
1-(4-amino-3-methylbenzyl)-3,5-bis(pentafluoroethyl)-1H-(1,2,4)-triazole,
[0192]
1-(4-amino-3-methylbenzyl)-2,5-bis(pentafluoroethyl)-1H-(1,3,4)-tr-
iazole, [0193]
2-(4-amino-3-methylphenyl)-5-(trifluoromethyl)-1,3,4-oxadiazole,
[0194]
2-(4-amino-3-methylphenyl)-5-(pentafluoroethyl)-1,3,4-oxadiazole,
[0195]
2-(4-amino-3-methylphenyl)-5-(heptafluoropropyl)-1,3,4-oxadiazole,
[0196]
2-(4-amino-3-methylbenzyl)-5-(trifluoromethyl)-1,3,4-oxadiazole,
[0197]
2-(4-amino-3-methylbenzyl)-4-(trifluoromethyl)-2H-1,2,3-triazole,
[0198] 2-(4-amino-3-methylbenzyl)-4-(pentafluoroethyl)-thiazole,
[0199]
5-(4-amino-3-methylphenyl)sulfanyl-1-methyl-3-(trifluoromethyl)-1H-1,2,4--
triazole, [0200]
3-(4-amino-3-methylphenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole,
[0201]
3-(4-amino-3-methylphenyl)-1-methyl-5-(trifluoromethyl)-1H-1,2,4-triazole-
, [0202]
1-(4-amino-3-chlorobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole,
[0203]
1-(4-amino-3-fluorobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole and
so on.
[0204] The compounds of the formula (IV), used as starting
materials in the above-mentioned preparation process (b), are novel
compounds and can be easily obtained according to the process
described in Japanese Laid-open Patent Publication No. 61-246161
(1986), for example, by reacting compounds of the formula (XD)
##STR00019##
wherein X has the same definition as aforementioned, with the
compounds of the formula (III).
##STR00020##
wherein Y, A, m and Q have the same definitions as
aforementioned.
[0205] The reaction can be conducted in an adequate diluent. As the
diluent used in that case there can be mentioned, for example,
aliphatic, alicyclic and aromatic hydrocarbons (may be optionally
chlorinated), for example, pentane, hexane, cyclohexane, petroleum
ether, ligroin, benzene, toluene, xylene, dichloromethane,
chloroform, carbon tetrachloride, 1,2-dichloroethane,
chlorobenzene, dichlorobenzene, etc.; ethers, for example, ethyl
ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane,
dimethoxyethane (DME), tetrahydrofuran (THF), diethylene glycol
dimethyl ether (DGM), etc.; esters, for example, ethyl acetate,
amyl acetate, etc.; acid amides, for example, dimethylformamide
(DMF), dimethylacetamide (DMA), N-methylpyrrolidone,
1,3-dimethyl-2-imidazolidinone, hexamethyl phosphoric triamide
(HMPA), etc.; acids, for example, acetic acid etc.
[0206] The reaction can be conducted in a substantially wide range
of temperature. It is adequate to conduct it at the temperatures in
a range of generally from room temperature (20.degree. C.) to about
200.degree. C., preferably from room temperature to 150.degree.
C.
[0207] Although said reaction is conducted desirably under normal
pressure, it can be operated also under elevated pressure or under
reduced pressure.
[0208] In conducting the reaction, the aimed compounds of the
formula (IV) can be obtained, for example, by reacting equimolar to
a little excess mole amount of the compounds of the formula (II) to
1 mole of the compounds of the formula (XII) in a diluent, for
example, acetic acid.
[0209] Many of the compounds of the above-mentioned formula (XII)
are publicly known, and as their specific examples there can be
mentioned, phthalic anhydride, 3-fluorophthalic anhydride,
3-chlorophthalic anhydride, 3-bromophthalic anhydride,
3-iodophthalic anhydride, 3-methanesulfonyloxyphthalic anhydride,
etc.
[0210] Among the above-mentioned compounds,
3-methanesulfonyloxyphthalic anhydride can be easily obtained from
3-hydroxyphthalic anhydride and methanesulfonyl chloride according
to the process described in Tetrahedron Letters Vol. 29, p. 5595-8
(1988).
[0211] As specific examples of the compounds of the formula (IV),
used as starting materials in the preparation process (b), there
can be mentioned the following: [0212]
4-chloro-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]ph-
enyl}-isoindole-1,3-dione, [0213]
2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl-methyl]-phenyl}-i-
soindole-1,3-dione, [0214]
4-chloro-2-[2-methyl-4-(5-difluoromethoxy-3-trifluoromethyl-1H-pyrazol-1--
yl-methyl)-phenyl]-isoindole-1,3-dione, [0215]
4-chloro-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl-methyl)-phenyl-
]-isoindole-1,3-dione, [0216]
4-bromo-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl-methyl]-p-
henyl}-isoindole-1,3-dione, [0217]
4-bromo-2-[2-methyl-4-(5-difluoromethoxy-3-trifluoromethyl-1H-pyrazol-1-y-
l-methyl)-phenyl]-isoindole-1,3-dione, [0218]
4-bromo-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl-methyl)-phenyl]-
-isoindole-1,3-dione, [0219]
4-iodo-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl-methyl]-ph-
enyl}-isoindole-1,3-dione, [0220]
4-iodo-2-[2-methyl-4-(5-difluoromethoxy-3-trifluoromethyl-1H-pyrazol-1-yl-
-methyl)-phenyl]-isoindole-1,3-dione, [0221]
4-iodo-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl-methyl)-phenyl]--
isoindole-1,3-dione, [0222]
4-iodo-2-[2-methyl-4-(5-hexafluoro-n-propyl-1H-pyrazol-1-yl-methyl)-pheny-
l]-isoindole-1,3-dione, [0223]
4-methanesulfonyloxy-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-
-yl-methyl]-phenyl}-isoindole-1,3-dione, [0224]
4-chloro-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-(1,2,4)-triazol-1-yl--
methyl]-phenyl}-isoindole-1,3-dione, [0225]
4-chloro-2-{2-methyl-4-[5-pentafluoroethyl-3-trifluoromethyl-1H-(1,2,4)-t-
riazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione, [0226]
4-chloro-2-{2-methyl-4-[5-difluoromethoxy-1-difluoromethyl-1H-(1,2,4)-tri-
azol-1-yl-methyl]-phenyl}-isoindole-1,3-dione, [0227]
4-iodo-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-(1,2,4)-triazol-1-yl-me-
thyl]-phenyl}-isoindole-1,3-dione, [0228]
4-iodo-2-{2-methyl-4-[5-pentafluoroethyl-3-trifluoromethyl-1H-(1,2,4)-tri-
azol-1-yl-methyl]-phenyl}-isoindole-1,3-dione, [0229]
4-iodo-2-{2-methyl-4-[5-difluoromethyl-3-trifluoromethyl-1H-(1,2,4)-triaz-
ol-1-yl-methyl]-phenyl}-isoindole-1,3-dione, [0230]
4-methanesulfonyloxy-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-(1,2,4)-t-
riazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione, [0231]
4-iodo-2-[2-methyl-4-(5-difluoromethoxy-1-difluoromethyl-3-trifluoromethy-
l-1H-pyrazol-4-yl-methyl)-phenyl]-isoindole-1,3-dione, [0232]
4-iodo-2-[2-methyl-4-(5-hydroxy-3,5-bis(trifluoromethyl)-1H-4,5-dihydropy-
razol-1-yl-methyl)-phenyl]-isoindole-1,3-dione, [0233]
4-iodo-2-{2-methyl-4-[2,4-bis(trifluoromethyl)-1H-imidazol-1-yl-methyl]-p-
henyl}-isoindole-1,3-dione, [0234]
4-iodo-2-{2-methyl-4-[3-(2,2,2-trifluoroethyl)-5-trifluoromethyl-1,2-dihy-
dro-(1,3,4)-triazol-2-on-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
[0235]
4-iodo-2-{2-methyl-4-[3-(2,2,2-trifluoroethyl)-3-trifluoromethyl-4,5-dihy-
dro-(1,2,4)-triazol-5-on-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
[0236]
4-iodo-2-{2-methyl-4-[2,5-bis(trifluoromethyl)-(1,3,4)-triazol-1-yl-methy-
l]-phenyl}-isoindole-1,3-dione, [0237]
4-iodo-2-{2-methyl-4-[4,6-bis(trifluoromethyl)pyrimidin-2-yl-methyl]-phen-
yl}-isoindole-1,3-dione, [0238]
4-iodo-2-{2-methyl-4-[4,6-bis(trifluoromethyl)pyrimidin-2-yloxy]-phenyl}--
isoindole-1,3-dione, [0239]
4-chloro-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}-
-isoindole-1,3-dione, [0240]
4-chloro-2-[2-methyl-4-(5-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoin-
dole-1,3-dione, [0241]
4-chloro-2-[2-methyl-4-(3-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoin-
dole-1,3-dione, [0242]
4-chloro-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoin-
dole-1,3-dione, [0243]
4-iodo-2-[2-methyl-4-[3-methyl-5-trifluoromethyl-1H-pyrazol-1-yl]-phenyl]-
-isoindole-1,3-dione, [0244]
4-iodo-2-[2-methyl-4-(5-methyl-3-trifluoromethyl-1H-pyrazol-1-yl)-phenyl]-
-isoindole-1,3-dione, [0245]
4-iodo-2-[2-methyl-4-(3-pentafluoroethyl-5-trifluoromethyl-1H-pyrazol-1-y-
l)-phenyl]-isoindole-1,3-dione, [0246]
4-iodo-2-[2-methyl-4-(4-bromo-3-trifluoromethyl-1H-pyrazol-1-yl)phenyl]-i-
soindole-1,3-dione, [0247]
4-iodo-2-[2-methyl-4-(3-trifluoromethyl-1H-pyrazol-1-yl)-phenyl]-isoindol-
e-1,3-dione, [0248]
4-iodo-2-{2-methyl-4-[5-hydroxy-3-(2,2,2-trifluoroethyl)-5-trifluoromethy-
l-1H-4,5-dihydropyrazol-1-yl]-phenyl}-isoindole-1,3-dione, [0249]
4-iodo-2-{2-methyl-4-[1-(2,2,2-trifluoroethyl)-3-trifluoromethyl-pyrazol--
5-yl]-phenyl}-isoindole-1,3-dione, [0250]
4-iodo-2-[2-methyl-4-(1-difluoromethyl-3-trifluoromethyl-pyrazol-5-yl)-ph-
enyl]-isoindole-1,3-dione, [0251] 4-iodo-2-[2-methyl-4
(1-difluoromethyl-3-difluoromethoxy-pyrazol-3-yl)-phenyl]-isoindole-1,3-d-
ione, [0252]
4-iodo-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}-i-
soindole-1,3-dione, [0253]
4-iodo-2-[2-methyl-4-(5-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindo-
le-1,3-dione, [0254]
4-iodo-2-[2-methyl-4-(3-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindo-
le-1,3-dione, [0255]
4-iodo-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindo-
le-1,3-dione, [0256]
4-bromo-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}--
isoindole-1,3-dione, [0257]
4-bromo-2-[2-methyl-4-(5-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoind-
ole-1,3-dione, [0258]
4-bromo-2-[2-methyl-4-(3-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoind-
ole-1,3-dione, [0259]
4-bromo-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoind-
ole-1,3-dione, [0260]
4-chloro-2-{2-methyl-4-[3,4-bis(pentafluoroethyl)-1H-pyrazol-1-ylmethyl]--
phenyl}-isoindole-1,3-dione, [0261]
4-chloro-2-{2-methyl-4-[3,5-bis(pentafluoroethyl)-1H-pyrazol-1-ylmethyl]--
phenyl}-isoindole-1,3-dione, [0262]
4-chloro-2-{2-methyl-4-[3,4-bis(heptafluoropropyl)-1H-pyrazol-1-ylmethyl]-
-phenyl}-isoindole-1,3-dione, [0263]
4-chloro-2-{2-methyl-4-[3,5-bis(heptafluoropropyl)-1H-pyrazol-1-ylmethyl]-
-phenyl}-isoindole-1,3-dione, [0264]
4-chloro-2-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-phenyl]-i-
soindole-1,3-dione, [0265]
4-chloro-2-[2-methyl-4-(5-pentafluoroethyl-1,3,4-oxadiazol-2-yl)-phenyl]--
isoindole-1,3-dione, [0266]
4-chloro-2-[2-methyl-4-(5-heptafluoropropyl-1,3,4-oxadiazol-2-yl)-phenyl]-
-isoindole-1,3-dione, [0267]
4-chloro-2-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl-methyl)-ph-
enyl]-isoindole-1,3-dione, [0268]
4-chloro-2-[2-methyl-4-(4-trifluoromethyl-2H-1,2,3-triazol-2-yl-methyl)-p-
henyl]-isoindole-1,3-dione, [0269]
4-chloro-2-[2-methyl-4-(4-(pentafluoroethyl)-thiazol-2-yl-methyl)-phenyl]-
-isoindole-1,3-dione, [0270]
4-chloro-2-{2-methyl-4-[1-methyl-3-(trifluoromethyl)-1H-1,2,4-triazol-5-y-
l-sulfanyl]-phenyl}-isoindole-1,3-dione, [0271]
4-chloro-2-[2-methyl-4-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)-phenyl]-i-
soindole-1,3-dione, [0272]
4-chloro-2-[2-methyl-4-(1-methyl-5-trifluoromethyl-1H-1,2,4-triazol-3-yl)-
-phenyl]-isoindole-1,3-dione, [0273]
4-iodo-2-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-phenyl]-iso-
indole-1,3-dione and so on.
[0274] The compounds of the formula (V), used as starting materials
in the preparation process (b), are either compounds well known in
the field of organic chemistry or can be synthesized according to
the process described in DE-A 20 45 905, WO 01/23350.
[0275] As their specific examples there can be mentioned
ethylamine, diethylamine, n-propylamine, isopropylamine,
n-butylamine, sec-butylamine, isobutylamine, t-butylamine,
t-amylamine, 2-(methylthio)-ethylamine, 2-(ethylthio)-ethylamine,
1-methyl-2-(methylthio)-ethylamine,
1,1-dimethyl-2-(methylthio)-ethylamine and so on.
[0276] The compounds of the formula (VI), used as starting
materials in the preparation process (c), include publicly known
compounds and can be easily prepared according to the process
described in JP-A 11-240857 (1999), JPA 2001-131141, etc.
[0277] As their specific examples there can be mentioned the
following: [0278] N-isopropyl-phthalamic acid, [0279]
3-fluoro-N-isopropyl-phthalamic acid, [0280]
3-chloro-N-isopropyl-phthalamic acid, [0281]
3-bromo-N-isopropyl-phthalamic acid, [0282]
3-iodo-N-isopropyl-phthalamic acid, [0283]
N-(1-methyl-2-methylsulfanyl-ethyl)-phthalamic acid, [0284]
3-fluoro-N-(1-methyl-2-methylsulfanyl-ethyl)-phthalamic acid,
[0285] 3-chloro-N-(1-methyl-2-methylsulfanyl-ethyl)-phthalamic
acid, [0286] 3-bromo-N-(1-methyl-2-methylsulfanyl-ethyl)-phthalamic
acid, [0287] 3-iodo-N-(1-methyl-2-methylsulfanyl-ethyl)-phthalamic
acid, [0288] N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-phthalamic
acid, [0289]
N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-3-fluoro-phthalamic acid,
[0290] 3-chloro-N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-phthalamic
acid, [0291]
3-bromo-N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-phthalamic acid,
[0292] N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-3-iodo-phthalamic
acid, [0293] N-isopropyl-3-methanesulfonyloxy-phthalamic acid,
[0294]
N-(1-methyl-2-methylsulfanyl-ethyl)-3-methanesulfonyloxy-phthalamic
acid, [0295] N-(1-methyl-2-methylsulfanyl-ethyl)-3-nitro-phthalamic
acid, [0296] 3-chloro-N-(2-ethylsulfanyl-1-methyl-ethyl)-phthalamic
acid, [0297] 3-bromo-N-(2-ethylsulfanyl-1-methyl-ethyl)-phthalamic
acid, [0298] N-(2-ethylsulfanyl-1-methyl-ethyl)-3-iodo-phthalamic
acid, [0299] N-(2-ethylsulfanyl-1-methyl-ethyl)-3-nitro-phthalamic
acid, [0300]
N-(2-ethylsulfanyl-1-methyl-ethyl)-3-methanesulfonyloxy-phthalamic
acid, [0301]
N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-3-methanesulfonyloxy-phtha-
lamic acid and so on.
[0302] The above-mentioned compounds of the formula (VI) can be
easily obtained generally by reacting phthalic anhydrides of the
aforementioned formula (XII)
##STR00021##
wherein X has the same definition as aforementioned, with amines of
the formula
H.sub.2N--R.sup.1 (XIII)
wherein R.sup.1 has the same definitions as aforementioned,
[0303] The compounds of the above-mentioned formula (XIII) are well
known in the field of organic chemistry and there can be
specifically mentioned, for example, ethylamine, n-propylamine,
isopropylamine, n-butylamine, sec-butylamine, isobutylamine,
t-butylamine, t-amylamine, 2-(methylthio)ethylamine,
2-(ethylthio)ethylamine, 1-methyl-2-(methylthio)ethylamine,
1,1-dimethyl-2-(methylthio)ethylamine, etc.
[0304] These amines can be easily obtained also by the process
described in DE-A 20 45 905, WO 01/23350, etc.
[0305] The above-mentioned reaction of the compounds of the formula
(XII) with the amines of the formula (XIII) can be conducted
according to the process described in, for example, J. Org. Chem.,
Vol. 46, p. 175 (1981) etc.
[0306] Said reaction can be conducted in an adequate diluent, and
as examples of the diluent used in that case there can be mentioned
aliphatic, alicyclic and aromatic hydrocarbons (may be optionally
chlorinated), for example, pentane, hexane, cyclohexane, petroleum
ether, ligroine, benzene, toluene, xylene, dichloromethane,
chloroform, carbon tetrachloride, 1,2-dichloroethane,
chlorobenzene, dichlorobenzene, etc.; ethers, for example, ethyl
ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane,
dimethoxyethane (DME), tetrahydrofuran (TIM, diethylene glycol
dimethyl ether (DGM), etc.; ketones, for example, acetone, methyl
ethyl ketone (MEK), methyl isopropyl ketone, methyl isobutyl ketone
(MIBK), etc.; nitriles, for example, acetonitrile, propionitrile,
acrylonitrile, etc.; esters, for example, ethyl acetate, amyl
acetate, etc.
[0307] The above-mentioned reaction can be conducted in the
presence of a base, and as said base there can be mentioned, for
example, tertiary amines, dialkylaminoanilines and pyridines, for
example, triethylamine, 1,1,4,4-tetramethylethylenediamine (TMEDA),
N,N-dimethylaniline, N,N-diethylaniline, pyridine,
4-dimethylaminopyridine (DMAP), 1,4-diazabicyclo[2,2,2]octane
(DABCO), 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU), etc.
[0308] The above-mentioned reaction can be conducted in a
substantially wide range of temperature. It is adequate to conduct
it at the temperatures in a range of generally from about -70 to
about 100.degree. C., preferably from about -50 to about 80.degree.
C.
[0309] Although said reaction is conducted desirably under normal
pressure, it can be operated also under elevated pressure or under
reduced pressure.
[0310] In conducting the above-mentioned reaction, the aimed
compounds of the formula (VI) can be obtained, for example, by
reacting 1-4 moles of the compounds of the formula (XIII) to 1 mole
of the compounds of the formula (XII) in a diluent, for example,
acetonitrile.
[0311] The compounds of the formula (VII), used as starting
materials in the preparation process (d), are novel compounds and
can be easily obtained, for example, by reacting the compounds of
the formula (VIII), starting materials in the below-mentioned
preparation process (e), according to the process described in J.
Med. Chem., Vol. 10, p. 982 (1967) etc. in the presence of a
condensing agent.
[0312] As specific examples of the compounds of the formula (VII),
there can be mentioned the following: [0313]
1-[4-(4-iodo-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,5--
bis(trifluoromethyl)-1H-pyrazole, [0314]
1-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,-
5-bis(trifluoromethyl)-1H-pyrazole, [0315]
1-[4-(4-iodo-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,5--
bis(trifluoromethyl)-1,2,4-triazole, [0316]
1-[4-(4-iodo-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-3,5-b-
is(trifluoromethyl)-1,1-pyrazole, [0317]
1-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,-
4-bis(pentafluoroethyl)-1H-pyrazole, [0318]
1-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,-
5-bis(pentafluoroethyl)-1H-pyrazole, [0319]
1-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,-
4-bis(heptafluoropropyl)-1H-pyrazole, [0320]
1-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,-
5-bis(heptafluoropropyl)-1H-pyrazole, [0321]
2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-5-(-
trifluoromethyl)-1,3,4-oxadiazole, [0322]
2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-5-(-
pentafluoroethyl)-1,3,4-oxadiazole, [0323]
2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-5-(-
heptafluoropropyl)-1,3,4-oxadiazole, [0324]
2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylbenzyl]-5-(-
trifluoromethyl)-1,3,4-oxadiazole, [0325]
2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylbenzyl]-4-(-
trifluoromethyl)-2H-1,2,3-triazole, [0326]
2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylbenzyl]-4-(-
pentafluoroethyl)-thiazole, [0327]
5-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]sulf-
anyl-1-methyl-3-(trifluoromethyl)-1H-1,2,4-triazole, [0328]
3-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-5-(-
trifluoromethyl)-1,2,4-oxadiazole, [0329]
3-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-1-m-
ethyl-5-(trifluoromethyl)-1H-1,2,4-triazole, [0330]
2-[4-(4-iodo-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-5-(tr-
ifluoromethyl)-1,3,4-oxadiazole and so on.
[0331] The compounds of the formula (V), similarly used as starting
materials in the preparation process (d), are the same as explained
in the aforementioned preparation process (b).
[0332] The compounds of the formula (VIII), used as starting
materials in the preparation process (e), are novel compounds and
can be easily obtained, for example, by reacting phthalic
anhydrides of the aforementioned formula (XII) with the compounds
of the aforementioned formula (III).
[0333] The above-mentioned reaction can be conducted in an adequate
diluent, and as examples of the diluent used in that case there can
be mentioned aliphatic, alicyclic and aromatic hydrocarbons (may be
optionally chlorinated), for example, pentane, hexane, cyclohexane,
petroleum ether, ligroine, benzene, toluene, xylene,
dichloromethane, chloroform, carbon tetrachloride,
1,2-dichloroethane, chlorobenzene, dichlorobenzene, etc.; ethers,
for example, ethyl ether, methyl ethyl ether, isopropyl ether,
butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (THF),
diethylene glycol dimethyl ether (DGM), etc.; ketones, for example,
acetone, methyl ethyl ketone (MEK), methyl isopropyl ketone, methyl
isobutyl ketone (MIBK), etc.; nitriles, for example, acetonitrile,
propionitrile; acrylonitrile, etc.; esters, for example, ethyl
acetate, amyl acetate, etc.
[0334] The above-mentioned reaction can be conducted in the
presence of a base, and as said base there can be mentioned
tertiary amines, dialkylaminoanilines and pyridines, for example,
triethylamine, 1,1,4,4-tetramethylethylenediamine (TMEDA),
N,N-dimethylaniline, N,N-diethylaniline, pyridine,
4-dimethylaminopyridine (DMAP), 1,4-diazabicyclo[2,2,2]octane
(DABCO) and 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU), etc.
[0335] The above-mentioned reaction can be conducted in a
substantially wide range of temperature. It is adequate to conduct
it at the temperatures in a range of generally from about -70 to
about 100.degree. C., preferably from about -50 to about 80.degree.
C.
[0336] Although said reaction is conducted desirably under normal
pressure, it can be operated also under elevated pressure or under
reduced pressure.
[0337] As specific examples of the compounds of the formula (VIII),
there can be mentioned the following: [0338]
N-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl-methyl]-2-methyl-phenyl}-6-
-iodo-phthalamic acid, [0339]
N-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl-methyl]-2-methyl-phenyl}-6-
-chloro-phthalamic acid, [0340]
N-{4-[3,5-bis(trifluoromethyl)-(1,2,4)-triazol-1-yl-methyl]-2-methyl-phen-
yl}-6-iodo-phthalamic acid, [0341]
N-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-2-methyl-phenyl}-6-iodo-p-
hthalamic acid, [0342]
N-{4-[3,4-bis(pentafluoroethyl)-1H-pyrazol-1-yl-methyl]phenyl}-6-chloro-p-
hthalamic acid, [0343]
N-{4-[3,5-bis(pentafluoroethyl)-1H-pyrazol-1-yl-methyl]-phenyl}-6-chloro--
phthalamic acid, [0344]
N-{4-[3,4-bis(heptafluoropropyl)-1H-pyrazol-1-yl-methyl]-phenyl}-6-chloro-
-phthalamic acid, [0345]
N-(4-[3,5-bis(heptafluoropropyl)-1H-pyrazol-1-yl-methyl]-phenyl)-6-chloro-
-phthalamic acid, [0346]
N-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-phenyl]-6-chloro-p-
hthalamic acid, [0347]
N-[2-methyl-4-(5-pentafluoroethyl-1,3,4-oxadiazol-2-yl)-phenyl]-6-chloro--
phthalamic acid, [0348]
N-[2-methyl-4-(5-heptafluoropropyl-1,3,4-oxadiazol-2-yl)-phenyl]-6-chloro-
-phthalamic acid, [0349]
N-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl-methyl)-phenyl]-6-c-
hloro-phthalamic acid, [0350]
N-[2-methyl-4-(4-trifluoromethyl-2H-1,2,3-triazol-2-yl-methyl)-phenyl]-6--
chloro-phthalamic acid, [0351]
N-{2-methyl-4-(4-pentafluoroethyl-thiazol-2-yl-methyl)-phenyl}-6-chloro-p-
hthalamic acid, [0352]
N-{2-methyl-4-[1-methyl-3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl-sufanyl-
]-phenyl}-6-chlorophthalamic acid, [0353]
N-[2-methyl-4-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)-phenyl]-6-chloro-p-
hthalamic acid, [0354]
N-[2-methyl-4-(1-methyl-5-trifluoromethyl-1H-1,2,4-triazol-3-yl)-phenyl]--
6-chloro-phthalamic acid, [0355]
N-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-phenyl]-6-iodo-pht-
halamic acid and so on.
[0356] The compounds of the formula (V), similarly used as starting
materials in the preparation process (e), can be the same as ones
used in the aforementioned preparation processes (b) and (d).
[0357] The compounds of the formula (If), used as starting
materials in the preparation process (f), are compounds included in
the formula (I) of the present invention.
[0358] By oxidizing the group R.sup.If in the compounds of the
formula (If), namely, C.sub.1-6alkylthio-C.sub.1-6alkyl, the
compounds of the formula (I), in which the group R.sup.If
corresponds to C.sub.1-6 alkylsulfinyl-C.sub.1-6alkyl or
C.sub.1-6alkylsulfonyl-C.sub.1-6alkyl, can be obtained.
[0359] The compounds of the formula (If) can be prepared by the
processes of the aforementioned preparation processes (a), (b),
(c), (d) and/or (e).
[0360] As specific examples of the compounds of the formula (If),
there can be mentioned the following: [0361]
3-iodo-N.sup.2-(1-methyl-2-methylsulfanyl-ethyl)-N.sup.1-{2-methyl-4-[3,5-
-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamide,
[0362]
N.sup.2-(1,1-dimethyl-2-methylsulfanyl-ethyl)-3-iodo-N.sup.1-{2-methyl-4--
[3,5-bis(trifluoro-methyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamide,
[0363]
3-iodo-N.sup.2-(1-methyl-2-methylsulfanyl-ethyl)-N.sup.1-{2-methyl-
-4-[3,5-bis(trifluoromethyl)-(1,2,4)-triazol-1-ylmethyl]-phenyl}phthalamid-
e, [0364]
3-chloro-N.sup.2-(1-methyl-2-methylsulfanyl-ethyl)-N.sup.1-{2-me-
thyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamide-
, [0365]
3-chloro-N.sup.2-(1-methyl-2-methylsulfanyl-ethyl)-N.sup.1-{2-met-
hyl-4-[3,4-bis(pentafluoro-ethyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamid-
e, [0366]
3-chloro-N.sup.2-(1-methyl-2-methylsulfanyl-ethyl)-N.sup.1-{2-me-
thyl-4-[3,5-bis(pentafluoro-ethyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalami-
de, [0367]
3-chloro-N.sup.2-(1-methyl-2-methylsulfanyl-ethyl)-N.sup.1-{2-m-
ethyl-4-[3,4-bis(heptafluoro-propyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthala-
mide, [0368]
3-chloro-N.sup.2-(1-methyl-2-methylsulfanyl-ethyl)-N.sup.1-{2-methyl-4-[3-
,5-bis(heptafluoro-propyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamide
and so on
[0369] The reaction of the aforementioned preparation process (a)
can be conducted in an adequate diluent singly or mixed. As
examples of the diluent used in that case there can be mentioned
water; aliphatic, alicyclic and aromatic hydrocarbons (may be
optionally chlorinated), for example, pentane, hexane, cyclohexane,
petroleum ether, ligroine, benzene, toluene, xylene,
dichloromethane, chloroform, carbon tetrachloride,
1,2-dichloroethane, chlorobenzene, dichlorobenzene, etc.; ethers,
for example, ethyl ether, methyl ethyl ether, isopropyl ether,
butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (THF),
diethylene glycol dimethyl ether (DGM), etc.; nitriles, for
example, acetonitrile, propionitrile, acrylonitrile, etc.; esters,
for example, ethyl acetate, amyl acetate, etc.
[0370] The preparation process (a) can be conducted in the presence
of an acid catalyst, and as examples of said acid catalyst there
can be mentioned mineral acids, for example, hydrochloric acid and
sulfuric acid; organic acids, for example, acetic acid,
trifluoroacetic acid, propionic acid, methanesulfonic acid,
benzenesulfonic acid, p-toluenesulfonic acid, etc.
[0371] The preparation process (a) can be conducted in a
substantially wide range of temperature. It is adequate to conduct
it at the temperatures in a range of generally from about -20 to
about 100.degree. C., preferably from about 0 to about 100.degree.
C.
[0372] Although said reaction is conducted desirably under normal
pressure, it can be operated also under elevated pressure or under
reduced pressure.
[0373] In conducting the preparation process (a), the aimed
compounds of the formula (I) can be obtained, for example, by
reacting 1 to a little excess mole amount of the compounds of the
formula (III) to 1 mole of the compounds of the formula (II) in a
diluent, for example, 1,2-dichloroethane in the presence of
0.01-0.1 mole amount of p-toluenesulfonic acid.
[0374] The reaction of the aforementioned preparation process (b)
can be conducted in an adequate diluent. As examples of the diluent
used in that case there can be mentioned aliphatic, alicyclic and
aromatic hydrocarbons (may be optionally chlorinated), for example,
pentane, hexane, cyclohexane, petroleum ether, ligroine, benzene,
toluene, xylene, dichloromethane, chloroform, carbon tetrachloride,
1,2-dichloroethane, chlorobenzene, dichlorobenzene, etc.; ethers,
for example, ethyl ether, methyl ethyl ether, isopropyl ether,
butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran
(Tiff), diethylene glycol dimethyl ether (DGM), etc.; esters, for
example, ethyl acetate, amyl acetate, etc.; acid amides, for
example, dimethylformamide (DMF), dimethylacetamide (DMA),
N-methylpyrrolidone, 1,3-dimethyl-2-imidazolidinone, hexamethyl
phosphoric triamide (HMPA), etc.
[0375] The preparation process (b) can be conducted in the presence
of an acid catalyst and as examples of said acid catalyst there can
be mentioned mineral acids, for example, hydrochloric acid and
sulfuric acid; organic acids, for example, acetic acid,
trifluoroacetic acid, propionic acid, methanesulfonic acid,
p-toluenesulfonic acid, etc.
[0376] The preparation process (b) can be conducted in a
substantially wide range of temperature. It is adequate to conduct
it at the temperatures in a range of generally from about -20 to
about 150.degree. C., preferably from room temperature (20.degree.
C.) to about 100.degree. C.
[0377] Although said reaction is conducted desirably under normal
pressure, it can be operated also under elevated pressure or under
reduced pressure.
[0378] In conducting the preparation process (b), the aimed
compounds of the formula (I) can be obtained, for example, by
reacting 1-25 moles of the compounds of the formula (V) to 1 mole
of the compounds of the formula (IV) in a diluent, for example,
dioxane in the presence of 0.01-0.5 mole amount of acetic acid.
[0379] The aforementioned preparation processes (c), (d) and (e)
can be conducted under the similar condition as the above-mentioned
preparation process (a).
[0380] The reaction of the aforementioned preparation process (f)
can be conducted in an adequate diluent. As examples of the diluent
used in that case there can be mentioned aliphatic, alicyclic and
aromatic hydrocarbons (may be optionally chlorinated), for example,
benzene, toluene, xylene, dichloromethane, chloroform, carbon
tetrachloride, 1,2-dichloroethane, chlorobenzene, dichlorobenzene,
etc.; alcohols, for example, methanol, ethanol, isopropanol and
butanol; acids; formic acid, acetic acid, etc.
[0381] As the oxidizing agents usable in the aforementioned
preparation process (f) there can be mentioned, for example,
m-chloroperbenzoic acid, peracetic acid, potassium metaperiodate,
potassium hydrogen persulfate (oxon), hydrogen peroxide, etc.
[0382] The preparation process (f) can be conducted in a
substantially wide range of temperature. It is adequate to conduct
it at the temperatures in a range of generally from about -50 to
about 150.degree. C., preferably from about -10 to about
100.degree. C.
[0383] Although said reaction is conducted desirably under normal
pressure, it can be operated also under elevated pressure or under
reduced pressure.
[0384] In conducting the preparation process (f), the aimed
compounds of the corresponding formula (I) can be obtained, for
example, by reacting 1-5 moles of an oxidizing agent to 1 mole of
the compounds of the formula (If) in a diluent, for example,
dichloromethane.
[0385] The reaction of the aforementioned preparation process (f)
can be conducted, for example, according to the process described
in JIKKEN KAGAKU KOZA (Lecture on experimental chemistry) edited by
the Chemical Society of Japan, 4.sup.th ed., Vol. 24, p. 350 (1992)
published by MARUZEN or ibid. p. 365.
[0386] The compounds of the formula (I) of the present invention
show strong insecticidal action. The compounds of the formula (I),
according to the present invention can, therefore, be used as
insecticidal agents. And the active compounds of the formula (I) of
the present invention exhibit exact controlling effect against
harmful insects without giving phytotoxicity on cultured plants.
And the compounds of the present invention can be used for
controlling a wide variety of pests, for example, harmful sucking
insects, biting insects and other plant-parasitic pests, stored
grain pests, hygienic pests, etc. and applied for their
extermination.
[0387] As examples of such pests there can be mentioned the
following pests:
[0388] As insects, there can be mentioned:
[0389] Coleoptera pests, for example, Callosobruchus Chinensis,
Sitophilus zeamais, Tribolium castaneum, Epilachna
vigintioctomaculata, Agriotes fuscicollis, Anomala rufocuprea,
Leptinotarsa decemlineata, Diabrotica spp., Monochamus alternatus,
Lissorhoptrus oryzophilus, Lyctus bruneus;
[0390] Lepidoptera pests, for example,
[0391] Lymantria dispar, Malacosoma neustria, Pieris rapae,
Spodoptera litura, Mamestra brassicae, Chilo suppressalis, Pyrausta
nubilalis, Ephestia cautella, Adoxophyes orana, Carpocapsa
pomonella, Agrotis fucosa, Galleria mellonella, Plutella
maculipennis, Heliothis virescens, Phyllocnistis citrella;
[0392] Hemiptera pests, for example,
[0393] Nephotettix cincticeps, Nilaparvata lugens, Pseudococcus
comstocki, Unaspis yanonensis, Myzus persicae, Aphis pomi, Aphis
gossypii, Rhopalosiphum pseudobrassicas, Stephanitis nashi, Nazara
spp., Trialeurodes vaporariorum, Psylla spp.;
[0394] Thysanoptera pests, for example,
[0395] Thrips palmi, Frankliniella occidental;
[0396] Orthoptera pests, for example,
[0397] Blatella gennanica, Periplaneta americana, Gryllotalpa
africana, Locusta migratoria migratoriodes;
[0398] Homoptera pests, for example,
[0399] Reticulitermes speratus, Coptotennes formosanus;
[0400] Diptera pests, for example,
[0401] Musca domestica, Aedes aegypti, Hylemia platura, Culex
pipiens, Anopheles slnensis, Culex tritaeniorlzynchus, Liriomyzae
trifolii etc.
[0402] Moreover, as mites there can be mentioned, for example,
[0403] Tetranychus cinnabarinus, Tetranychus urticae, Panonychus
citri, Aculops pelekassi, Tarsonemus spp., etc.
[0404] Furthermore, as nematodes there can be mentioned, for
example,
[0405] Meloidogyne incognita, Bursaphelenchus lignicolus Mamiya et
Kiyohara, Aphelenchoides besseyi, Heterodera glycines, Pratylenchus
spp., etc.
[0406] In addition, in the field of veterinary medicine, the novel
compounds of the present invention can be effectively used against
various harmful animal-parasitic pests (endoparasites and
ectoparasites), for example, insects and helminthes. As examples of
such animal-parasitic pests there can be mentioned the following
pests:
[0407] As insects there can be mentioned, for example,
[0408] Gastrophilus spp., Stomoxys spp., Trichodectes spp.,
Rhodnius spp., Ctenocephalides canis, Cimex lectularius etc.
[0409] As mites there can be mentioned, for example,
[0410] Ornithodoros spp., Ixodes spp., Boophilus spp., etc.
[0411] In the present invention, substances having insecticidal
action against pests, which include all of them, are in some cases
called as insecticides.
[0412] All plants and plant parts can be treated in accordance with
the invention. Plants are to be understood as meaning in the
present context all plants and plant populations such as desired
and undesired wild plants or crop plants (including naturally
occurring crop plants). Crop plants can be plants which can be
obtained by conventional plant breeding and optimization methods or
by biotechnological and genetic engineering methods or by
combinations of these methods, including the transgenic plants and
including the plant cultivars protectable or not protectable by
plant breeders' rights. Plant parts are to be understood as meaning
all parts and organs of plants above and below the ground, such as
shoot, leaf, flower and root, examples which may be mentioned being
leaves, needles, stalks, stems, flowers, fruit bodies, fruits,
seeds, roots, tubers and rhizomes. The plant parts also include
harvested material, and vegetative and generative propagation
material, for example cuttings, tubers, rhizomes, offshoots and
seeds.
[0413] Treatment according to the invention of the plants and plant
parts with the active compounds is carried out directly or by
allowing the compounds to act on the surroundings, environment or
storage space by the customary treatment methods, for example by
immersion, spraying, evaporation, fogging, scattering, painting on
and, in the case of propagation material, in particular in the case
of seeds, also by applying one or more coats.
[0414] The active compounds, according to the present invention,
can be converted into the customary formulation forms, when they
are used as insecticides. As formulation forms there can be
mentioned, for example, solutions, emulsions, wettable powders,
water dispersible granules, suspensions, powders, foams, pastes,
tablets, granules, aerosols, natural and synthetic materials
impregnated with active compound, microcapsules, seed coating
agents, formulations used with burning equipment (as burning
equipment, for example, fumigation and smoking cartridges, cans,
coils, etc.), ULV [cold mist, warm mist], etc.
[0415] These formulations can be produced according to per se known
methods, for example, by mixing the active compounds with
extenders, namely liquid diluents or carriers; liquefied gas
diluents or carriers; solid diluents or carriers, and optionally
with surface-active agents, namely emulsifiers and/or dispersants
and/or foam-forming agents.
[0416] In case that water is used as extender, for example, organic
solvents can also be used as auxiliary solvents.
[0417] As liquid diluents or carriers there can be mentioned, for
example, aromatic hydrocarbons (for example, xylene, toluene,
alkylnaphthalene, etc.), chlorinated aromatic or chlorinated
aliphatic hydrocarbons (for example, chlorobenzenes, ethylene
chlorides, methylene chloride, etc.), aliphatic hydrocarbons [for
example, cyclohexane etc. or paraffins (for example, mineral oil
fractions etc.)], alcohols (for example, butanol, glycols and their
ethers, esters, etc.), ketones (for example, acetone, methyl ethyl
ketone, methyl isobutyl ketone, cyclohexanone, etc.), strongly
polar solvents (for example, dimethylformamide, dimethyl sulfoxide,
etc.), and water.
[0418] Liquefied gas diluents or carriers are substances that are
gases at normal temperature and pressure and there can be
mentioned, for example, aerosol propellants such as butane,
propane, nitrogen gas, carbon dioxide, halogenated
hydrocarbons.
[0419] As solid diluents there can be mentioned, for example,
ground natural minerals (for example, kaolin, clay, talc, chalk,
quartz, attapulgite, montmorillonite, diatomaceous earth, etc.),
ground synthetic minerals (for example, highly dispersed silicic
acid, alumina, silicates, etc.).
[0420] As solid carriers for granules there can be mentioned, for
example, crushed and fractionated rocks (for example, calcite,
marble, pumice, sepiolite, dolomite, etc.), synthetic granules of
inorganic or organic meals, particles of organic materials (for
example, saw dust, coconut shells, maize cobs, tobacco stalks,
etc.), etc.
[0421] As emulsifiers and/or foam-forming agents, there can be
mentioned, for example, nonionic and anionic emulsifiers [for
example, polyoxyethylene fatty acid esters, polyoxyethylene fatty
acid alcohol ethers (for example, alkylaryl polyglycol ethers),
alkylsulfonates, alkylsulfates, arylsulfonates, etc.], albumin
hydrolysis products, etc.
[0422] Dispersants include, for example, lignin sulfite waste
liquor and methyl cellulose.
[0423] Tackifiers can also be used in formulations (powders,
granules, emulsifiable concentrates). As said tackifiers, there can
be mentioned, for example, carboxymethyl cellulose, natural or
synthetic polymers (for example, gum Arabic, polyvinyl alcohol,
polyvinyl acetate, etc.).
[0424] Colorants can also be used. As said colorants there can be
mentioned, for example, inorganic pigments (for example, iron
oxide, titanium oxide, Prussian Blue, etc,), organic dyestuffs such
as alizarin dyestuffs, azo dyestuffs or metal phthalocyanine
dyestuffs, and further trace nutrients such as salts of iron,
manganese, boron, copper, cobalt, molybdenum and zinc.
[0425] Said formulations can contain the aforementioned active
component of the amount in the range of generally 0.1-95% by
weight, preferably 0.5-90% by weight.
[0426] The active compounds of the formula (I) of the present
invention can exist also as a mixed agent with other active
compounds, for example, insecticides, poisonous baits,
bactericides, miticides, nematicides, fungicides, growth regulators
or herbicides in the form of their commercially useful formulations
and in the application forms prepared from such formulations. Here,
as the above-mentioned insecticides, there can be mentioned, for
example, organophosphorous agents, carbamate agents, carboxylate
type chemicals, chlorinated hydrocarbon type chemicals,
insecticidal substances produced by microorganisms, etc.
[0427] Further, the active compounds of the formula (I) of the
present invention can exist also as a mixed agent with a synergist,
and such formulations and application forms can be mentioned as
commercially useful. Said synergist itself must not be active, but
is a compound that enhances the action of the active compound.
[0428] Particularly favourable mixing components are, for example,
the following compounds:
Fungicides:
[0429] 2-phenylphenol; 8-hydroxyquinoline sulfate;
acibenzolar-S-methyl; aldimorph; amidoflumet; ampropylfos;
ampropylfos-potassium; andoprim; anilazine; azaconazole;
azoxystrobin; benalaxyl; benalaxyl-M; benodanil; benomyl;
benthiavalicarb-isopropyl; benzamacril; benzamacril-isobutyl;
bilanafos; binapacryl; biphenyl; bitertanol; blasticidin-S;
boscalid; bromuconazole; bupirimate; buthiobate; butylamine;
calcium polysulfide; capsimycin; captafol; captan; carbendazim;
carboxin; carpropamid; carvone; chinomethionat; chlobenthiazone;
chlorfenazole; chloroneb; chlorothalonil; chlozolinate; clozylacon;
cyazofamid; cyflufenamid; cymoxanil; cyproconazole; cyprodinil;
cyprofuram; Dagger G; debacarb; dichlofluanid; dichlone;
dichlorophen; diclocymet; diclomezine; dicloran; diethofencarb;
difenoconazole; diflumetorim; dimethirimol; dimethomorph;
dimoxystrobin; diniconazole; diniconazole-M; dinocap;
diphenylamine; dipyrithione; ditalimfos; dithianon; dodine;
drazoxolon; edifenphos; epoxiconazole; ethaboxam; ethirimol;
etridiazole; famoxadone; fenamidone; fenapanil; fenarimol;
fenbuconazole; fenfuram; fenhexamid; fenitropan; fenoxanil;
fenpiclonil; fenpropidin; fenpropimorph; ferbam; fluazinam;
flubenzimine; fludioxonil; flumetover, flumorph; fluoromide;
fluoxastrobin; fluquinconazole; flurprimidol; flusilazole;
flusulfamide; flutolanil; flutriafol; folpet; fosetyl-A1;
fosetyl-sodium; fuberidazole; furalaxyl; furametpyr; furcarbanil;
furmecyclox; guazatine; hexachlorobenzene; hexaconazole; hymexazol;
imazalil; imibenconazole; iminoctadine triacetate; iminoctadine
tris(albesilate); iodocarb; ipconazole; iprobenfos; iprodione;
iprovalicarb; irumamycin; isoprothiolane; isovaledione;
kasugamycin; kresoxim-methyl; mancozeb; maneb; meferimzone;
mepanipyrim; mepronil; metalaxyl; metalaxyl-M; metconazole;
methasulfocarb; methfuroxam; metiram; metominostrobin; metsulfovax;
mildiomycin; myclobutanil; myclozolin; natamycin; nicobifen;
nitrothal-isopropyl; noviflumuron; nuarimol; ofurace; orysastrobin;
oxadixyl; oxolinic acid; oxpoconazole; oxycarboxin; oxyfenthiin;
paclobutrazol; pefurazoate; penconazole; pencycuron; phosdiphen;
phthalide; picoxystrobin; piperalin; polyoxins; polyoxorim;
probenazole; prochloraz; procymidone; propamocarb;
propanosine-sodium; propiconazole; propineb; proquinazid;
prothioconazole; pyraclostrobin; pyrazophos; pyrifenox;
pyrimethanil; pyroquilon; pyroxyfur; pyrrolnitrin; quinconazole;
quinoxyfen; quintozene; simeconazole; spiroxamine; sulfur;
tebuconazole; tecloftalam; tecnazene; tetcyclacis; tetraconazole;
thiabendazole; thicyofen; thifluzamide; thiophanate-methyl; thiram;
tioxymid; tolclofos-methyl; tolylfluanid; triadimefon; triadimenol;
triazbutil; triazoxide; tricyclamide; tricyclazole; tridemorph;
trifloxystrobin; triflumizole; triforine; triticonazole;
uniconazole; validamycin A; vinclozolin; zineb; ziram; zoxamide;
(2S)-N-[2-[4-[[3-(4-chlorophenyl)-2-propynyl]oxy]-3-methoxyphenyl]ethyl]--
3-methyl-2-[(methylsulfonyl)amino]-butanamide;
1-(1-naphthalenyl)-1H-pyrrol-2,5-dione;
2,3,5,6-tetrachloro-4-(methylsulfonyl)-pyridine;
2-amino-4-methyl-N-phenyl-5-thiazolecarboxamide;
2-chloro-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-3-pyridinecarboxam-
ide; 3,4,5-trichloro-2,6-pyridinedicarbonitrile; actinovate;
cis-1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)-cycloheptanol;
methyl
1-(2,3-dihydro-2,2-dimethyl-1H-inden-1-yl)-1H-imidazole-5-carboxylate;
mono potassium carbonate; N-(6-methoxy-3-pyridinyl)-cyclopropane
carboxamide;
N-butyl-8-(1,1-dimethylethyl)-1-oxaspiro[4.5]decan-3-amine; sodium
tetrathiocarbonate; and copper salts and preparations, such as
Bordeaux mixture; copper hydroxide; copper naphthenate; copper
oxychloride; copper sulphate; cufraneb; copper oxide; mancopper;
oxine-copper.
Bactericides:
[0430] bronopol, dichlorophen, nitrapyrin, nickel
dimethyldithiocarbamate, kasugamycin, octhilinone, furancarboxylic
acid, oxytetracyclin, probenazole, streptomycin, tecloftalam,
copper sulphate and other copper preparations.
Insecticides/Acaricides/Nematicides:
[0431] 1. Acetylcholinesterase (AChE) inhibitors
[0432] 1.1 Carbamates (e.g. alanycarb, aldicarb, aldoxycarb,
allyxycarb, aminocarb, azamethiphos, bendiocarb, benfuracarb,
bufencarb, butacarb, butocarboxim, butoxycarboxim, carbaryl,
carbofuran, carbosulfan, chloethocarb, coumaphos, cyanofenphos,
cyanophos, dimetilan, ethiofencarb, fenobucarb, fenothiocarb,
formetanate, furathiocarb, isoprocarb, metam-sodium, methiocarb,
methomyl, metolcarb, oxamyl, pirimicarb, promecarb, propoxur,
thiodicarb, thiofanox, triazamate, trimethacarb, XMC,
xylylcarb)
[0433] 1.2 Organophosphates (e.g. acephate, azamethiphos, azinphos
(-methyl, -ethyl), bromophos-ethyl, bromfenvinfos (-methyl),
butathiofos, cadusafos, carbophenothion, chlorethoxyfos,
chlorfenvinphos, chlormephos, chlorpyrifos (-methyl/-ethyl),
coumaphos, cyanofenphos, cyanophos, chlorfenvinphos,
demeton-s-methyl, demeton-s-methylsulphon, dialifos, diazinon,
dichlofenthion, dichloriros/ddvp, dicrotophos, dimethoate,
dimethylvinphos, dioxabenzofos, disulfoton, epn, ethion,
ethoprophos, etrimfos, famphur, fenamiphos, fenitrothion,
fensulfothion, fenthion, flupyrazofos, fonofos, formothion,
fosmethilan, fosthiazate, heptenophos, iodofenphos, iprobenfos,
isazofos, isofenphos, isopropyl o-salicylate, isoxatbion,
malathion, mecarbam, methacrifos, methamidophos, methidathion,
mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl,
parathion (-methyl/-ethyl), phenthoate, phorate, phosalone,
phosmet, phosphamidon, phosphocarb, phoxim, pirimiphos
(-methyl/-ethyl), profenofos, propaphos, propetamphos, prothiofos,
prothoate, pyraclofos, pyridaphenthion, pyridathion, quinalphos,
sebufos, sulfotep, sulprofos, tebupirimfos, temephos, terbufos,
tetrachlorvinphos, thiometon, triazophos, triclorfon,
vamidothion)
[0434] 2. Sodium channel modulators/voltage dependant sodium
channel blockers
[0435] 2.1 Pyrethroids (e.g. acrinathrin, allethrin (d-cis-trans,
d-trans), beta-cyflutbrin, bifenthrin, bioallethrin,
bioallethrin-s-cyclopentyl-isomer, bioethanometbrin, biopermethrin,
bioresmethrin, chlovaporthrin, cis-cypermethrin, cis-resmethrin,
cis-permethrin, clocythrin, cycloprothrin, cyfluthrin, cyhalothrin,
cypermethrin (alpha-, beta-, theta-, zeta), cyphenothrin, DDT,
deltamethrin, empenthrin (1R-isomer), esfenvalerate, etofenprox,
fenfluthrin, fenpropathrin, fenpyrithrin, fenvalerate,
flubrocythrinate, flucythrinate, flufenprox, flumetbrin,
fluvalinate, fubfenprox, gamma-cyhalothrin, imiprothrin, kadethrin,
lambda-cyhalothrin, metofluthrin, permethrin (cis-, trans),
phenothrin (1R-trans isomer), prallethrin, proflutbrin,
protrifenbute, pyresmethrin, resmethrin, RU 15525, silafluofen,
tau-fluvalinate, tefluthrin, terallethrin, tetramethrin
(1R-isomer), tralomethrin, transfluthrin, ZXI 8901, pyrethrins
(pyrethrum))
[0436] 2.2 Oxadiazine (e.g. indoxacarb)
[0437] 3. Acetylcholine receptor agonists/-antagonists
[0438] 3.1 Chloronicotinyls/neonicotinoids (e.g. acetamiprid,
clothianidin, dinotefuran, imidacloprid, nitenpyram, nithiazine,
thiacloprid, thiamethoxam)
[0439] 3.2 nicotine, bensultap, cartap
[0440] 4. Acetylcholine receptor modulators
[0441] 4.1 Spinosyns (e.g. spinosad)
[0442] 5. GABA gated chloride channel antagonists
[0443] 5.1 Cyclodiene organochlorines (e.g. camphechlor, chlordane,
endosulfan, gamma HCH, HCH, heptachlor, lindane, methoxychlor
[0444] 5.2 Fiproles (e.g. acetoprole, ethiprole, fipronil,
vaniliprole)
[0445] 6. Chloride channel activators
[0446] 6.1 Mectins (e.g. abaraectin, avermectin, emamectin,
emamectin-benzoate, ivermectin, milbemectin, milbemycin)
[0447] 7. Juvenile hormone mimics
[0448] (e.g. diofenolan, epofenonane, fenoxycarb, hydroprene,
kinoprene, methoprene, pyriproxifen, triprene)
[0449] 8. Ecdysone agonists/disruptors
[0450] 8.1 Diacylhydrazines (e.g. chromafenozide, halofenozide,
methoxyfenozide, tebufenozide)
[0451] 9. Inhibitors of chitin biosynthesis
[0452] 9.1 Benzoylureas (e.g. bistrifluoron, chlofluazuron,
diflubenzuron, fluazuron, flucycloxuron, flufenoxuron,
hexaflumuron, lufenuron, novaluron, noviflumuron, penfluoron,
teflubenzuron, tifiumuron)
[0453] 9.2 buprofezin
[0454] 9.3 cyromazine
[0455] 10. Inhibitors of oxidative phosphorylation,
ATP-disruptors
[0456] 10.1 diafenthiuron
[0457] 10.2 Organotins (e.g. azocyclotin, cyhexatin,
fenbutatin-oxide)
[0458] 11. Decoupler of oxidative phoshorylation by diruption of H
proton gradient
[0459] 11.1 Pyrroles (e.g. chlorfenapyr)
[0460] 11.2 Dinitrophenoles (e.g. binapacyrl, dinobuton, dinocap,
DNOC)
[0461] 12. Site I electron transport inhibitors
[0462] 12.1 METT's (e.g. fenazaquin, fenpyroximate, pyrimidifen,
pyridaben, tebufenpyrad, tolfenpyrad)
[0463] 12.2 hydramethyhione
[0464] 12.3 dicofol
[0465] 13. Site II electron transport inhibitors
[0466] 13.1 rotenone
[0467] 14. Site II electron transport inhibitors
[0468] 14.1 acequinocyl, fluacrypyrim
[0469] 15. Microbial disruptors of insect midgut membranes
[0470] Bacillus thuringiensis strains
[0471] 16. Inhibitors of lipid synthesis
[0472] 16.1 Tetronic acid insecticides (e.g. spirodiclofen,
spiromesifen)
[0473] 16.2 Tetramic acid insecticides [e.g.
3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl
ethyl carbonate (alias: carbonic acid,
3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]-dec-3-en-4-yl
ethyl ester, CAS-Reg.-No.: 382608-10-8) and carbonic acid,
cis-3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl
ethyl ester (CAS-Reg.-No.: 203313-25-1)]
[0474] 17. Carboxamides
[0475] (e.g. flonicamid)
[0476] 18. Octopaminergic agonists
[0477] (e.g. amitraz)
[0478] 19. Inhibitors of magnesium stimulated ATPase
[0479] (e.g. propargite)
[0480] 20. Phthalamides
[0481] (e.g.
N.sup.2-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N.sup.1-[2-methyl-4-
-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]-1,2-benzenedicarbox-
amide (CAS-Reg.-No.: 272451-65-7, flubendiamide))
[0482] 21. Nereistoxin analogues
[0483] (e.g. thiocyclam hydrogen oxalate, thiosultap-sodium)
[0484] 22. Biologica, hormones or pheromones
[0485] (e.g. azadirachtin, Bacillus spec., Beauveria spec.,
codlemone, Metarrhizium spec., Paecilomyces spec., thuringiensin,
Verticillium spec.)
[0486] 23. Compounds of unknown or non-specific mode of action
[0487] 23.1 Fumigants (e.g. aluminium phosphide, methyl bromide,
sulfa yl fluoride)
[0488] 23.2 Selective feeding blockers (e.g. cryolite, flonicamid,
pymetrozine)
[0489] 23.3 Mite growth inhibitors (e.g. clofentezine, etoxazole,
hexythiazox)
[0490] 23.4 amidoflumet, benclothiaz, benzoximate, bifenazate,
bromopropylate, buprofezin, chinomethionat, chlordimeform,
chlorobenzilate, chloropicrin, clothiazoben, cycloprene,
cyflumetofen, dicyclanil, fenoxacrim, fentrifanil, flubenzimine,
flufenerim, flutenzin, gossyplure, hydramethylnone, japonilure,
metoxadiazone, petroleum, piperonyl butoxide, potassium oleate,
pyrafluprole, pyridalyl, pyriprole, sulfluramid, tetradifon,
tetrasul, triarathene, verbutin
[0491] further the compound 3-methyl-phenyl-propylcarbamate
(Tsumacide Z), the compound
3-(5-chloro-3-pyridinyl)-8-(2,2,2-trifluoroethyl)-8-azabicyclo[3.2.1]octa-
n-3-carbonitrile (CAS-Reg.-Nr. 185982-80-3) and the corresponding
3-endo isomer (CAS-Reg.-Nr. 185984-60-5) (cf. WO 96/37494, WO
98/25923), and preparations comprising insecticidal active plant
extracts, nematodes, fungi or viruses.
[0492] A mixture with other known active compounds, such as
herbicides, fertilizers, growth regulators, safeners and/or
semiochemicals is also possible.
[0493] When used as insecticides, the active compounds according to
the invention can furthermore be present in their commercially
available formulations and in the use forms, prepared from these
formulations, as a mixture with synergistic agents. Synergistic
agents are compounds, which increase the action of the active
compounds, without it being necessary for the synergistic agent
added to be active itself.
[0494] When used as insecticides, the active compounds according to
the invention can furthermore be present in their commercially
available formulations and in the use forms, prepared from these
formulations, as a mixture with inhibitors which reduce degradation
of the active compound after use in the vicinity of the plant, on
the surface of parts of plants or in plant tissues.
[0495] The content of the active compounds of the formula (I) of
the present invention in a commercially useful application form can
be varied in a wide range.
[0496] The concentration of the active compounds of the formula (I)
of the present invention at the time of actual usage can be, for
example, in the range of 0.0000001-100% by weight, preferably
0.00001-1% by weight.
[0497] The compounds of the formula (I) of the present invention
can be applied by usual methods suitable to the application
forms.
[0498] In case of application against hygiene pests and pests of
stored products, the active compounds of the present invention have
a good stability against alkali on limed substrates and further
show an excellent residual effectiveness on wood and soil.
[0499] As already mentioned above, it is possible to treat all
plants and their parts according to the invention. In a preferred
embodiment, wild plant species and plant cultivars, or those
obtained by conventional biological breeding methods, such as
crossing or protoplast fusion, and parts thereof, are treated. In a
further preferred embodiment, transgenic plants and plant cultivars
obtained by genetic engineering, if appropriate in combination with
conventional methods (Genetically Modified Organisms), and parts
thereof are treated. The term "parts" or "parts of plants" or
"plant parts" has been explained above.
[0500] Particularly preferably, plants of the plant cultivars which
are in each case commercially available or in use are treated
according to the invention. Plant cultivars are to be understood as
meaning plants having certain properties ("traits") which have been
obtained by conventional breeding, by mutagenesis or by recombinant
DNA techniques. These can be cultivars, bio- or genotypes.
[0501] Depending on the plant species or plant cultivars, their
location and growth conditions (soils, climate, vegetation period,
diet), the treatment according to the invention may also result in
superadditive ("synergistic") effects. Thus, for example, reduced
application rates and/or a widening of the activity spectrum and/or
an increase in the activity of the substances and compositions to
be used according to the invention, better plant growth, increased
tolerance to high or low temperatures, increased tolerance to
drought or to water or soil salt content, increased flowering
performance, easier harvesting, accelerated maturation, higher
harvest yields, better quality and/or a higher nutritional value of
the harvested products, better storage stability and/or
processability of the harvested products are possible which exceed
the effects which were actually to be expected.
[0502] The transgenic plants or plant cultivars (i.e. those
obtained by genetic engineering) which are preferably to be treated
according to the invention include all plants which, in the genetic
modification, received genetic material which imparted particularly
advantageous useful traits to these plants. Examples of such traits
are better plant growth, increased tolerance to high or low
temperatures, increased tolerance to drought or to water or soil
salt content, increased flowering performance, easier harvesting,
accelerated maturation, higher harvest yields, better quality
and/or a higher nutritional value of the harvested products, better
storage stability and/or processability of the harvested products.
Further and particularly emphasized examples of such traits are a
better defence of the plants against animal and microbial pests,
such as against insects, mites, phytopathogenic fungi, bacteria
and/or viruses, and also increased tolerance of the plants to
certain herbicidally active compounds. Examples of transgenic
plants which may be mentioned are the important crop plants, such
as cereals (wheat, rice), maize, soya beans, potatoes, cotton,
tobacco, oilseed rape and also fruit plants (with the fruits
apples, pears, citrus fruits and grapes), and particular emphasis
is given to maize, soya beans, potatoes, cotton, tobacco and
oilseed rape. Traits that are emphasized are in particular
increased defence of the plants against insects, arachnids,
nematodes and worms by toxins formed in the plants, in particular
those formed in the plants by the genetic material from Bacillus
thuringiensis (for example by the genes CryIA(a), CryIA(b),
CryIA(c), CryIIA, CryIIIA, CryIIIB2, Cry9c, Cry2Ab, Cry3Bb and
CryIF and also combinations thereof) (hereinbelow referred to as
"Bt plants"). Traits that are also particularly emphasized are the
increased defence of the plants against fungi, bacteria and viruses
by systemic acquired resistance (SAR), systemin, phytoalexius,
elicitors and resistance genes and correspondingly expressed
proteins and toxins. Traits that are furthermore particularly
emphasized are the increased tolerance of the plants to certain
herbicidally active compounds, for example imidazolinones,
sulphonylureas, glyphosate or phosphinotricin (for example the
"PAT" gene). The genes which impart the desired traits in question
can also be present in combination with one another in the
transgenic plants. Examples of "Bt plants" which may be mentioned
are maize varieties, cotton varieties, soya bean varieties and
potato varieties which are sold under the trade names YIELD
GARD.RTM. (for example maize, cotton, soya beans), KnockOut.RTM.
(for example maize), StarLink.RTM. (for example maize),
Bollgard.RTM. (cotton), Nucotn.RTM. (cotton) and NewLeaf.RTM.
(potato). Examples of herbicide-tolerant plants which may be
mentioned are maize varieties, cotton varieties and soya bean
varieties which are sold under the trade names Roundup Ready.RTM.
(tolerance to glyphosate, for example maize, cotton, soya bean),
Liberty Link.RTM. (tolerance to phosphinotricin, for example
oilseed rape), IMI.RTM. (tolerance to imidazolinones) and STS.RTM.
(tolerance to sulphonylureas, for example maize).
Herbicide-resistant plants (plants bred in a conventional manner
for herbicide tolerance) which may be mentioned include the
varieties sold under the name Clearfield.RTM. (for example maize).
Of course, these statements also apply to plant cultivars having
these genetic traits or genetic traits still to be developed, which
plants will be developed and/or marketed in the future.
[0503] The plants listed can be treated according to the invention
in a particularly advantageous manner with the compounds of the
general formula I and/or the active compound mixtures according to
the invention. The preferred ranges stated above for the active
compounds or mixtures also apply to the treatment of these plants.
Particular emphasis is given to the treatment of plants with the
compounds or mixtures specifically mentioned in the present
text.
[0504] Then the present invention will be described more
specifically by examples. The present invention, however, should
not be restricted only to them in any way.
SYNTHESIS EXAMPLES
Synthesis Example 1
##STR00022##
[0506]
3-(1,1-Dimethyl-2-methylsulfanyl-ethylimino)-4-iodo-3H-isobenzofura-
n-1-one (0.53 g) and
1-(3-methyl-4-aminobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole
(0.45 g) were dissolved in acetonitrile (15 ml), to which
p-toluenesulfonic acid monohydrate (0.01 g) was added and the
mixture was stirred at 60.degree. C. for 3 hours. After finishing
the reaction, the solvent was distilled off under reduced pressure
and the residue was purified by silica gel column chromatography to
obtaining
N.sup.1-[4-(3,5-bistrifluoromethylpyrazol-1-ylmethyl)-2-methylphenyl]-N.s-
up.2-(1,1-dimethyl-2-methylsulfanylethyl)-3-iodophthalamide (0.91
g). mp. 83-87.degree. C.
Synthesis Example 2
##STR00023##
[0508]
N.sup.1-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methy-
lphenyl}-N.sup.2-(1,1-dimethyl-2-methylsulfanylethyl)-3-iodophthalamide
(0.5 g) was dissolved in dichloromethane, to which
m-chloroperbenzoic acid (0.26 g) was added and the mixture was
stirred for 5 hours under ice cooling. After finishing the
reaction, the mixture was washed successively with aqueous solution
of sodium thiosulfate, saturated aqueous solution of sodium
bicarbonate and saturated aqueous solution of sodium chloride, and
dried with anhydrous magnesium sulfate. After distilling off the
solvent, the obtained residue was purified by silica gel column
chromatography to obtain
N.sup.1-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylpheny-
l}-N.sup.2-(2-methanesulfinyl-1,1-dimethylethyl)-3-iodophthalamide
(0.30 g).
[0509] .sup.1H-NMR (CDCl.sub.3, ppm): 1.57 (3H, s), 1.60 (3H, s),
2.20 (3H, s), 2.30 (3H, s), 2.93 (2H, dd), 5.43 (2H, s), 6.57 (1H,
s), 6.90 (1H, s), 7.0-8.2 (7H, m).
Synthesis Example 3
##STR00024##
[0511]
N.sup.1-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methy-
lphenyl}-N.sup.2-(1,1-dimethyl-2-methylsulfanylethyl)-3-iodophthalamide
(0.30 g) was dissolved in dichloromethane, to which
m-chloroperbenzoic acid (0.26 g) was added and the mixture was
stirred at room temperature for 5 hours. After finishing the
reaction, the mixture was washed successively with aqueous solution
of sodium thiosulfate, saturated aqueous solution of sodium
bicarbonate and saturated aqueous solution of sodium chloride, and
dried with anhydrous magnesium sulfate. After distilling off the
solvent, the obtained crude crystals were washed with petroleum
ether to obtain
N.sup.1-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylpheny-
l}-3-iodo-N.sup.2-(2-methanesulfonyl-1,1-dimethylethyl)phthalamide
(0.25 g). mp. 104-107.degree. C.
Synthesis Example 4
##STR00025##
[0513] A dioxane solution (15 ml) of
2-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylphenyl}-4-f-
luoroisoindole-1,3-dione (0.94 g),
(S)-1-methyl-2-methylsulfanylethylamine (0.63 g) and acetic acid
(0.12 g) was refluxed for 18 hours. After cooling to room
temperature, the solvent was distilled off and the obtained residue
was purified by silica gel column chromatography to obtain
N.sup.1-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-meth-
ylphenyl}-3-fluoro-N.sup.2-[1-(S)-1-methyl-2-methylsulfanyl-ethyl]-phthala-
mide (0.19 g) (compound No. 549). mp. 66-68.degree. C.
Synthesis Example 5
##STR00026##
[0515] 3-Iodo-N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-phthalamic
acid (0.39 g) and N-(3-dimethylaminopropyl)-N.sup.1-ethylcarbonyl
diimidazole hydrochloride (0.19 g) were stirred in dichloromethane
(10 ml) at room temperature for 30 minutes. Then,
2-methyl-4-[1-(3-trifluoromethyl-1H-pyrazol-1-yl)-ethyl]-aniline
(0.30 g) and p-toluenesulphonic acid monohydrate (0.02 g) were
added thereto and the mixture was stirred at room temperature for 3
hours. After distilling off the solvent under reduced pressure, the
obtained residue was purified by silica gel column chromatography
to obtain
N.sup.2-(1,1-dimethyl-2-methylsulfanyl-ethyl)-3-iodo-N.sup.1-{2-methyl-4--
[1-(3-trifluoromethyl-1H-pyrazol-1-yl)-ethyl]-phenyl}-phthalamide
(0.38 g) (compound No. 558). mp. 79-86.degree. C.
[0516] The compounds of the formula (I), according to the present
invention, which can be obtained in the Same manner as the
above-mentioned Synthesis Examples 1 to 5 are shown in Table 1,
together with the compounds obtained in the above-mentioned
Synthesis Examples 1 to 5.
[0517] NMR data of the compounds, whose mp. column is marked as
***, are collectively shown in Table 2, separately from Table
1.
TABLE-US-00001 TABLE 1 ##STR00027## ##STR00028## ##STR00029##
##STR00030## No. R.sup.1 X Y A m Q R.sup.2 R.sup.3 R.sup.4 mp 1
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-H 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H *** 2 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-H
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 3
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-H 2-CH.sub.3 CH.sub.2 1
Q1 CF.sub.3 CF.sub.3 H *** 4 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-H
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 5
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-H 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 6 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-H
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 7 CH(CH.sub.3).sub.2
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 8
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H *** 9 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 80-84 10
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 CF.sub.3 H 183-186 11 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H *** 12
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 76-81 (S)-isomer 13
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 185-193 14 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 192-194 (S)-isomer 15
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H *** 16 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 88-93 (S)-isomer
17 CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1
Q1 CF.sub.3 CF.sub.3 H (S)-isomer 18
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 19
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 20
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H 21 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H 22
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 OCHF.sub.2 H 23 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H 24
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H (S)-isomer 25 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H 26
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H (S)-isomer 27
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H 28 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H (S)-isomer 29
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H (S)-isomer 30
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H (S)-isomer 31
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 OCHF.sub.2 H (S)-isomer 32
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H
H C.sub.2F.sub.5 33 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 34
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 H H C.sub.2F.sub.5 35 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 36
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H H
C.sub.2F.sub.5 (S)-isomer 37 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 38
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H H
C.sub.2F.sub.5 (S)-isomer 39 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 40
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
H H C.sub.2F.sub.5 (S)-isomer 41
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H
H C.sub.2F.sub.5 (S)-isomer 42 CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 (S)-isomer 43
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 H H C.sub.2F.sub.5 (S)-isomer 44 CH(CH.sub.3).sub.2 3-Br
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 45
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 154-160 46 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 47
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 CF.sub.3 H *** 48 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 147-155 49
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 80-86 (S)-isomer 50
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 51 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 207-209 (S)-isomer 52
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H *** 53 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 77-85 (S)-isomer
54 CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1
Q1 CF.sub.3 CF.sub.3 H (S)-isomer 55
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 56
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 57
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H 58 C(CH.sub.3).sub.2SOCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H 59
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 OCHF.sub.2 H 60 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H 61
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H (S)-isomer 62 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H 63
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H (S)-isomer 64
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H 65 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H (S)-isomer 66
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H (S)-isomer 67
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H (S)-isomer 68
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 OCHF.sub.2 H (S)-isomer 69
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1 H
H C.sub.2F.sub.5 70 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 71
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2
1 Q1 H H C.sub.2F.sub.5 72 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 73
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1 H H
C.sub.2F.sub.5 (S)-isomer 74 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 75
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1 H H
C.sub.2F.sub.5 (S)-isomer 76 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 77
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
H H C.sub.2F.sub.5 (S)-isomer 78
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1 Q1 H
H C.sub.2F.sub.5 (S)-isomer 79 CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5
3-Br 2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 (S)-isomer 80
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2
1 Q1 H H C.sub.2F.sub.5 (S)-isomer 81 CH(CH.sub.3).sub.2 3-I
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H *** 82
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 83-87 83 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H *** 84
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q1 CF.sub.3 CF.sub.3 H 104-107 85 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H *** 86
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3
CF.sub.3 H 85-93 (S)-isomer 87 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 213-215 88
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 193-195 (S)-isomer 89
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H *** 90 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 87-93 (S)-isomer 91
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 79-83 (S)-isomer 92
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 93
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 CF.sub.3 H 79-91 (S)-isomer 94
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H
C.sub.3F.sub.7-n H *** 95 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 H C.sub.3F.sub.7-n H 96
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q1 H C.sub.3F.sub.7-n H *** 97 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 H C.sub.3F.sub.7-n H *** 98
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H
C.sub.3F.sub.7-n H 99 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 H
C.sub.3F.sub.7-n H *** 100 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H 101
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H 102 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H 103
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3
OCHF.sub.2 H *** 104 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3
CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H (S)-isomer 105
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H 106 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H (S)-isomer 107
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H *** 108 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 OCHF.sub.2 H (S)-isomer 109
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H (S)-isomer 110
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 OCHF.sub.2 H (S)-isomer 111
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 OCHF.sub.2 H (S)-isomer 112
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H H
C.sub.2F.sub.5 113 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 114
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q1 H H C.sub.2F.sub.5 115 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 116
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H H
C.sub.2F.sub.5 *** (S)-isomer 117 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 118
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H H
C.sub.2F.sub.5 (S)-isomer 119 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 120
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H
H C.sub.2F.sub.5 (S)-isomer 121 CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5
3-I 2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.2F.sub.5 (S)-isomer 122
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H
H C.sub.2F.sub.5 (S)-isomer 123
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2
1 Q1 H H C.sub.2F.sub.5 (S)-isomer 124
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-OSO2CH3 2-CH.sub.3 CH.sub.2 1
Q1 CF.sub.3 CF.sub.3 H 125 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-OSO2CH3 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 126
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-OSO2CH3 2-CH.sub.3
CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 127 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-OSO2CH3 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 128
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-OSO2CH3 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 177-180 (S)-isomer 129
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-OSO2CH3 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 130 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-OSO2CH3
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 131
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-OSO2CH3 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 CF.sub.3 H 132 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-OSO2CH3 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 85-93
(S)-isomer 133 CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-OSO2CH3
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 134
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-OSO2CH3 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 135
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-OSO2CH3 2-CH.sub.3
CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 136 CH(CH.sub.3).sub.2
3-Cl 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 137
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 70-72 138 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 84-90 139
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CF.sub.3 -- 88-95 140 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 76-80 141
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 72-81 (S)-isomer 142
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 186-188 143 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 195-198
(S)-isomer 144 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3
CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 116-118 145
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 95-99 (S)-isomer 146
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 73-76 (S)-isomer 147
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 180-183 (S)-isomer 148
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CF.sub.3 -- 66-72 (S)-isomer 149
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- *** 150
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 59-64 151
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q2 C.sub.2F.sub.5 CF.sub.3 -- 82-87 152
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 153 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- *** (S)-isomer
154 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 155 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- 175-178
(S)-isomer 156 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3
CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- 157
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 82-90 (S)-isomer 158
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 159
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 160
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2
1 Q2 C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 161
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- 162 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- 163
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CHF.sub.2 -- 164 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- 165
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- (S)-isomer 166 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- 167
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- (S)-isomer 168
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- 169 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- (S)-isomer 170
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- (S)-isomer 171
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- (S)-isomer 172
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CHF.sub.2 -- (S)-isomer 173 CH(CH.sub.3).sub.2 3-Br
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 174
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 77-82 175 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 176
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CF.sub.3 -- 151-155 177 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 167-169 178
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 68-73 (S)-isomer 179
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 180 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- *** (S)-isomer 181
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 90-98 182 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 99-112
(S)-isomer 183 CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Br 2-CH.sub.3
CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- (S)-isomer 184
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- (S)-isomer 185
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CF.sub.3 -- (S)-isomer 186
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 187 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- 188
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2
1 Q2 C.sub.2F.sub.5 CF.sub.3 -- 189 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- 190
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 191
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 192 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 193
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 194 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer
195 CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1
Q2 C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 196
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 197
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2
1 Q2 C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 198
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- 199 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- 200
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CHF.sub.2 -- 201 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 --
202 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- (S)-isomer 203 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- 204
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- (S)-isomer 205
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- 206 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- (S)-isomer 207
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- (S)-isomer 208
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- (S)-isomer 209
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CHF.sub.2 -- (S)-isomer 210 CH(CH.sub.3).sub.2 3-I
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 102-105 211
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 93-97 212 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 92-93 213
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q2 CF.sub.3 CF.sub.3 -- 104-107 214 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 92-95 215
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3
CF.sub.3 -- 81-90 (S)-isomer 216 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 192-195 217
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 192-199 (S)-isomer 218
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 99-104 219
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 164-167 (S)-isomer 220
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 90-94 (S)-isomer 221
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 201-205 (S)-isomer 222
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CF.sub.3 -- 91-99 (S)-isomer 223
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 224 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- 225
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q2 C.sub.2F.sub.5 CF.sub.3 -- 226 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- 89-94 227
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 91-104 (S)-isomer 228
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 229 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- 190-193
(S)-isomer 230 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3
CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- 99-116 231
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 126-132 (S)-isomer 232
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 233
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 234
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2
1 Q2 C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 235
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- 236 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- 237
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q2 CF.sub.3 CHF.sub.2 238 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- 85-88 239
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3
CHF.sub.2 -- 160-161 (S)-isomer 240 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- 241
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- (S)-isomer 242
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- *** 243 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- 174-178
(S)-isomer 244 CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3
CH.sub.2 1 Q2 CF.sub.3 CHF.sub.2 -- (S)-isomer 245
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CHF.sub.2 -- (S)-isomer 246
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CHF.sub.2 -- (S)-isomer 247
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-OSO2CH3 2-CH.sub.3 CH.sub.2 1
Q2 CF.sub.3 CF.sub.3 -- 248 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-OSO2CH3 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 249
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-OSO2CH3 2-CH.sub.3
CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 250
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-OSO2CH3 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 251 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-OSO2CH3
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- *** (S)-isomer 252
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-OSO2CH3 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 253 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-OSO2CH3
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- (S)-isomer 254
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-OSO2CH3 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CF.sub.3 -- 255 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-OSO2CH3 2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- 207-208
(S)-isomer 256 CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-OSO2CH3
2-CH.sub.3 CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- (S)-isomer 257
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-OSO2CH3 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CF.sub.3 -- (S)-isomer 258
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-OSO2CH3 2-CH.sub.3
CH.sub.2 1 Q2 CF.sub.3 CF.sub.3 -- (S)-isomer 259
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q3
OCHF.sub.2 CHF.sub.2 CF.sub.3 260
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q3
OCHF.sub.2 CHF.sub.2 CF.sub.3 261
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q3 OCHF.sub.2 CHF.sub.2 CF.sub.3 262 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q3 OCHF.sub.2 CHF.sub.2 CF.sub.3 82-90
263 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q3
OCHF.sub.2 CHF.sub.2 CF.sub.3 264
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q3
OCHF.sub.2 CHF.sub.2 CF.sub.3 88-99 265
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q4
OCHF.sub.2 CHF.sub.2 CF.sub.3 266
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q4
OCHF.sub.2 CHF.sub.2 CF.sub.3 267
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q4 OCHF.sub.2 CHF.sub.2 CF.sub.3 268 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q4 OCHF.sub.2 CHF.sub.2 CF.sub.3 149-151
269 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q4
OCHF.sub.2 CHF.sub.2 CF.sub.3 270
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q4
OCHF.sub.2 CHF.sub.2 CF.sub.3 81-90 271
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q5
CF.sub.3 CF.sub.3 OH *** 272 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q5 CF.sub.3 CF.sub.3 OH 273
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q5 CF.sub.3 CF.sub.3 OH 274 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q5 CF.sub.3 CF.sub.3 OH 275
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q5
CF.sub.3 CF.sub.3 OH 276 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q5 CF.sub.3 CF.sub.3 OH 277
CH(CH.sub.3).sub.2 3-I 2-CH.sub.3 CH.sub.2 1 Q6 Cl Cl H *** 278
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q6 H
CF.sub.3 CF.sub.3 279 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q6 H CF.sub.3 CF.sub.3 280
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q6 H CF.sub.3 CF.sub.3 281 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q6 H CF.sub.3 CF.sub.3 149-158 (S)-isomer 282
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q6 H
CF.sub.3 CF.sub.3 283 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q6 H CF.sub.3 CF.sub.3 284
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q7
CH.sub.2CF.sub.3 CF.sub.3 -- 285 C(CH.sub.3).sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q7 CH.sub.2CF.sub.3 CF.sub.3 -- 286
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q7 CH.sub.2CF.sub.3 CF.sub.3 -- 287 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q7 CH.sub.2CF.sub.3 CF.sub.3 -- 288
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q7
CH.sub.2CF.sub.3 CF.sub.3 -- 289
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q7
CH.sub.2CF.sub.3 CF.sub.3 -- 290 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q8 CH.sub.2CF.sub.3 CF.sub.3 -- 291
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q8
CH.sub.2CF.sub.3 CF.sub.3 -- 292
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q8 CH.sub.2CF.sub.3 CF.sub.3 -- 293 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q8 CH.sub.2CF.sub.3 CF.sub.3 -- 294
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q8
CH.sub.2CF.sub.3 CF.sub.3 -- 295
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q8
CH.sub.2CF.sub.3 CF.sub.3 -- 296 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3 CF.sub.3 -- 297
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- 298 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3 CF.sub.3 -- 299
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3
CF.sub.3 -- 65-79 (S)-isomer 300 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3 CF.sub.3 -- 301
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- 302 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q10 CF.sub.3 CF.sub.3 H 303
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q10
CF.sub.3 CF.sub.3 H 304 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q10 CF.sub.3 CF.sub.3 H 305
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q10
CF.sub.3 CF.sub.3 H 306 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q10 CF.sub.3 CF.sub.3 H 307
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q10
CF.sub.3 CF.sub.3 H 308 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 O 1 Q10 CF.sub.3 CF.sub.3 H 179-181 309
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 O 1 Q10 CF.sub.3
CF.sub.3 H 310 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 O 1 Q10 CF.sub.3 CF.sub.3 H 148-153 311
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 O 1 Q10 CF.sub.3
CF.sub.3 H
312 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 O 1 Q10 CF.sub.3
CF.sub.3 H 313 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3
O 1 Q10 CF.sub.3 CF.sub.3 H 314 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-Cl 2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H 315
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H 316 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3
3-Cl 2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H 317
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1 CF.sub.3
CF.sub.3 H 318 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 -- 0
Q1 CF.sub.3 CF.sub.3 H 209-210 (S)-isomer 319
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1 CF.sub.3
CF.sub.3 H 320 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 -- 0
Q1 CF.sub.3 CF.sub.3 H (S)-isomer 321
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H 322 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H 218-219 (S)-isomer 323
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 324
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 325
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 326
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H 327 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q1 H C.sub.2F.sub.5 H 328
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H 329 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3
-- 0 Q1 H C.sub.2F.sub.5 H 330 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q1 H C.sub.2F.sub.5 H (S)-isomer 331
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H 332 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3
-- 0 Q1 H C.sub.2F.sub.5 H (S)-isomer 333
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H 334 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q1 H C.sub.2F.sub.5 H (S)-isomer 335
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H (S)-isomer 336
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H (S)-isomer 337
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 -- 0 Q1
H C.sub.2F.sub.5 H (S)-isomer 338
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H 339 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H 340
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H 341 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H 342
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 343 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Cl 2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H 344
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 345
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H 346 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H (S)-isomer 347
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 348
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 349
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 350
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 351 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 352
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1 H
H C.sub.2F.sub.5 353 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3
-- 0 Q1 H H C.sub.2F.sub.5 354 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 (S)-isomer 355
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 356 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3
-- 0 Q1 H H C.sub.2F.sub.5 (S)-isomer 357
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 358 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 (S)-isomer 359
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 (S)-isomer 360 CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5
3-Cl 2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 (S)-isomer 361
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 -- 0 Q1
H H C.sub.2F.sub.5 (S)-isomer 362
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1 CF.sub.3
CF.sub.3 H 363 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3
-- 0 Q1 CF.sub.3 CF.sub.3 H 364
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H 365 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H 366
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1 CF.sub.3
CF.sub.3 H (S)-isomer 367 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H 368
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1 CF.sub.3
CF.sub.3 H (S)-isomer 369 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H 370
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 371
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Br 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 372
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Br 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 373
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Br 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 374
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H 375 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 H C.sub.2F.sub.5 H 376
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H 377 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3
-- 0 Q1 H C.sub.2F.sub.5 H 378 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 H C.sub.2F.sub.5 H (S)-isomer 379
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H 380 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3
-- 0 Q1 H C.sub.2F.sub.5 H (S)-isomer 381
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H 382 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 H C.sub.2F.sub.5 H (S)-isomer 383
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Br 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H (S)-isomer 384
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Br 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H (S)-isomer 385
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Br 2-CH.sub.3 -- 0 Q1
H C.sub.2F.sub.5 H (S)-isomer 386
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H 387 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H 388
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H 389 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H 390
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 391 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Br 2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H 392
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 393
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H 394 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H (S)-isomer 395
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Br 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 396
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Br 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 397
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Br 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 398
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 399 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 400
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1 H
H C.sub.2F.sub.5 401 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3
-- 0 Q1 H H C.sub.2F.sub.5 402 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 (S)-isomer 403
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 404 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3
-- 0 Q1 H H C.sub.2F.sub.5 (S)-isomer 405
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 406 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br
2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 (S)-isomer 407
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Br 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 (S)-isomer 408 CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5
3-Br 2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 (S)-isomer 409
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Br 2-CH.sub.3 -- 0 Q1
H H C.sub.2F.sub.5 (S)-isomer 410
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 CF.sub.3
CF.sub.3 H 411 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3
-- 0 Q1 CF.sub.3 CF.sub.3 H 412
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H 413 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3
H 201 414 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H 192-206 (S)-isomer 415
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 CF.sub.3
CF.sub.3 H 416 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0
Q1 CF.sub.3 CF.sub.3 H (S)-isomer 417
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H *** 418 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 419
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3 -- 0 Q1 CF.sub.3
CF.sub.3 H (S)-isomer 420 CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I
2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 421
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 422
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H *** 423 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 H C.sub.2F.sub.5 H 424
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H 425 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3
-- 0 Q1 H C.sub.2F.sub.5 H 426 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 H C.sub.2F.sub.5 H (S)-isomer 427
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H 428 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3
-- 0 Q1 H C.sub.2F.sub.5 H (S)-isomer 428
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H 430 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 H C.sub.2F.sub.5 H (S)-isomer 431
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H (S)-isomer 432
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H (S)-isomer 433
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 -- 0 Q1 H
C.sub.2F.sub.5 H (S)-isomer 434 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H *** 435
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H 436 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H 437
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5
H H 438 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 439 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H 440
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 441
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H 442 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H H (S)-isomer 443
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 444
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 445
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H H (S)-isomer 446
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 155-157 447 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 448
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 H
H C.sub.2F.sub.5 162-168 449 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 450
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 (S)-isomer 451 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 452
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 (S)-isomer 453 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 454
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 (S)-isomer 455 CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5
3-I 2-CH.sub.3 -- 0 Q1 H H C.sub.2F.sub.5 (S)-isomer 456
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 -- 0 Q1 H H
C.sub.2F.sub.5 (S)-isomer 457
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 -- 0 Q1 H
H C.sub.2F.sub.5 (S)-isomer 458 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 -- 0 Q1 CH.sub.3 CF.sub.3 H 459
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 CH.sub.3
CF.sub.3 H 460 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 CH.sub.3 CF.sub.3 H 461
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 CH.sub.3
CF.sub.3 H 178-180 462 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 CH.sub.3 CF.sub.3 H 463
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
CH.sub.3 CF.sub.3 H 101-112 464 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 -- 0 Q1 CF.sub.3 CH.sub.3 H 465
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 CF.sub.3
CH.sub.3 H 466 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 CF.sub.3 CH.sub.3 H 467
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 CF.sub.3
CH.sub.3 H 187-192 468 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 CF.sub.3 CH.sub.3 H 469
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
CF.sub.3 CH.sub.3 H 108-116 470 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 CF.sub.3 H 471
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 CF.sub.3 H 472
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 CF.sub.3 H 473 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 CF.sub.3 H 109-111 474
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 CF.sub.3 H 475 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 CF.sub.3 H 103-115 476
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 CF.sub.3
H Br 477 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
CF.sub.3 H Br 478 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 CF.sub.3 H Br 479 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 -- 0 Q1 CF.sub.3 H Br 235-237 480
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 CF.sub.3 H Br
481 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
CF.sub.3 H Br 201-209 482 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 CF.sub.3 H H 483
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 CF.sub.3
H H 484 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 --
0 Q1 CF.sub.3 H H 485 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3
-- 0 Q1 CF.sub.3 H H 173-174 486 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 CF.sub.3 H H 487
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q1
CF.sub.3 H H 107-109 488 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-OSO2CH3 2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H 489
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-OSO2CH3 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H 490 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3
3-OSO2CH3 2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H 491
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-OSO2CH3 2-CH.sub.3 -- 0 Q1 CF.sub.3
CF.sub.3 H 492 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-OSO2CH3 2-CH.sub.3
-- 0 Q1 CF.sub.3 CF.sub.3 H 175-177 (S)-isomer 493
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-OSO2CH3 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H 494 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-OSO2CH3
2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 495
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-OSO2CH3 2-CH.sub.3 -- 0 Q1
CF.sub.3 CF.sub.3 H 496 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-OSO2CH3 2-CH.sub.3 -- 0 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 497
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q5
C.sub.2F.sub.5 CF.sub.3 OH 498 C(CH.sub.3).sub.2CH.sub.3SOCH.sub.3
3-I 2-CH.sub.3 -- 0 Q5 C.sub.2F.sub.5 CF.sub.3 OH 499
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q5
C.sub.2F.sub.5 CF.sub.3 OH 500 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 -- 0 Q5 C.sub.2F.sub.5 CF.sub.3 OH 101-106 501
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q5
C.sub.2F.sub.5 CF.sub.3 OH 502 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 -- 0 Q5 C.sub.2F.sub.5 CF.sub.3 OH 503
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q11
CH.sub.2CF.sub.3 H CF.sub.3 504 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 -- 0 Q11 CH.sub.2CF.sub.3 H CF.sub.3 505
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q11
CH.sub.2CF.sub.3 H CF.sub.3 506 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 -- 0 Q11 CH.sub.2CF.sub.3 H CF.sub.3 106-118 507
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q11
CH.sub.2CF.sub.3 H CF.sub.3 508
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q11
CH.sub.2CF.sub.3 H CF.sub.3 127-139 509
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q11
CHF.sub.2 H CF.sub.3 510 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 -- 0 Q11 CHF.sub.2 H CF.sub.3 511
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q11
CHF.sub.2 H CF.sub.3 512 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 -- 0 Q11 CHF.sub.2 H CF.sub.3 138-144 513
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q11 CHF.sub.2 H
CF.sub.3 514 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 --
0 Q11 CHF.sub.2 H CF.sub.3 515 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 -- 0 Q12 CHF.sub.2 H OCHF.sub.2 516
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q12
CHF.sub.2 H OCHF.sub.2 517
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 -- 0 Q12
CHF.sub.2 H OCHF.sub.2 518 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 -- 0 Q12 CHF.sub.2 H OCHF.sub.2 83-89 519
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 -- 0 Q12 CHF.sub.2 H
OCHF.sub.2 520 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3
-- 0 Q12 CHF.sub.2 H OCHF.sub.2 91-97 521
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H
C.sub.2F.sub.5 H *** 522 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 H C.sub.2F.sub.5 H *** 523
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H
C.sub.2F.sub.5 H *** 524 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 H C.sub.2F.sub.5 H 525
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H H 526 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H H 527 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3
CH.sub.2 1 Q1 C.sub.2F.sub.5 H H 528
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H H 529 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 H H *** 530
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q1 C.sub.2F.sub.5 H H *** 531 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 C.sub.3F.sub.7-n H H 532
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H H *** (S)-isomer 533
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H H 534 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 C.sub.3F.sub.7-n H H *** 535
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H H (S)-isomer 536
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H H *** 537 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 C.sub.3F.sub.7-n H H *** 538
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q1 C.sub.3F.sub.7-n H H *** 539
CH(CH.sub.3)CH.sub.2SCH(CH.sub.3).sub.2 3-I 2-CH.sub.3 CH.sub.2 1
Q1 CF.sub.3 CF.sub.3 H 81-83 (S)-isomer 540
CH(CH.sub.3)CH.sub.2SOCH(CH.sub.3).sub.2 3-I 2-CH.sub.3 CH.sub.2 1
Q1 CF.sub.3 CF.sub.3 H (S)-isomer 541
CH(CH.sub.3)CH.sub.2SO.sub.2CH(CH.sub.3).sub.2 3-I 2-CH.sub.3
CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 542
CH(CH.sub.3)CH.sub.2SCH(CH.sub.3).sub.2 3-Cl 2-CH.sub.3 CH.sub.2 1
Q1 CF.sub.3 CF.sub.3 H (S)-isomer 543 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-NO.sub.2 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 161-171
(S)-isomer 544 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-NO.sub.2 2-CH.sub.3
CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 227-229 (S)-isomer 545
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-NO.sub.2 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 CF.sub.3 H 215-216 (S)-isomer 546
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-NO.sub.2 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 175-179 (S)-isomer 547
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-NO.sub.2 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.3 CF.sub.3 -- 225-228 (S)-isomer 548
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-NO.sub.2 2-CH.sub.3 CH.sub.2
1 Q2 CF.sub.3 CF.sub.3 -- 206-208 (S)-isomer 549
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-F 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3
CF.sub.3 H 66-68 (S)-isomer 550 CH(CH.sub.3).sub.2 3-SCH.sub.3
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H *** 551
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-SCH.sub.3 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 552 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-SO.sub.2CH.sub.3 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H ***
(S)-isomer 553 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-SCH.sub.2CH.sub.3
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H *** (S)-isomer 554
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3
CF.sub.3 I *** (S)-isomer 555 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH(CH.sub.3) 1 Q1 CF.sub.3 H H 556
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q1
CF.sub.3 H H 78-89 (S)-isomer 557
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1
Q1 CF.sub.3 H H 150-152 (S)-isomer 558
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q1
CF.sub.3 H H 79-86 559 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH(CH.sub.3) 1 Q1 CF.sub.3 CF.sub.3 H 80-91 (S)-isomer
560 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1
Q1 CF.sub.3 CF.sub.3 H (S)-isomer 561
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1
Q1 CF.sub.3 CF.sub.3 H 103-105 (S)-isomer 562
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q1
CF.sub.3 CF.sub.3 H 84-89 (S)-isomer 563
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q1
CF.sub.3 CF.sub.3 H 177-179 (S)-isomer 564
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1
Q1 CF.sub.3 CF.sub.3 H 101-105 (S)-isomer 565
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q1
CF.sub.3 CF.sub.3 H 98-106 566 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q1 CF.sub.3 CF.sub.3 H 132-136 567
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3
CH(CH.sub.3) 1 Q1 CF.sub.3 CF.sub.3 H 173-174 568
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1 Q2
CF.sub.3 CF.sub.3 -- 87-92 (S)-isomer 569
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1 Q2
CF.sub.3 CF.sub.3 -- *** (S)-isomer 570
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1
Q2 CF.sub.3 CF.sub.3 -- 91-95 (S)-isomer 571
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q2
CF.sub.3 CF.sub.3 -- 98-105 (S)-isomer 572
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q2
CF.sub.3 CF.sub.3 -- 98-105 (S)-isomer 573
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1
Q2 CF.sub.3 CF.sub.3 -- 103-106 (S)-isomer 574
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1 Q2
CF.sub.3 C.sub.2F.sub.5 -- *** (S)-isomer 575
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1 Q2
CF.sub.3 C.sub.2F.sub.5 -- (S)-isomer 576
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1
Q2 CF.sub.3 C.sub.2F.sub.5 -- (S)-isomer 577
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q2
CF.sub.3 C.sub.2F.sub.5 -- (S)-isomer 578
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 83-85 (S)-isomer 579
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1 Q2
C.sub.2F.sub.5 CF.sub.3 -- 121-124 (S)-isomer 580
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1
Q2 C.sub.2F.sub.5 CF.sub.3 -- 87-94 (S)-isomer 581
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 582
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 583
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 S 1 Q10 CF.sub.3
CF.sub.3 H (S)-isomer 584 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 S 1 Q10 CF.sub.3 CF.sub.3 H (S)-isomer 585
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 S 1 Q10
C.sub.2F.sub.5 C.sub.2F.sub.5 H (S)-isomer 586
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 S 1 Q10 C.sub.2F.sub.5
C.sub.2F.sub.5 H (S)-isomer 587 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 S 1 Q13 CF.sub.3 CF.sub.3 -- (S)-isomer 588
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 S 1 Q13 CF.sub.3
CF.sub.3 -- 223-225 (S)-isomer 589 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 SO.sub.2 1 Q13 CF.sub.3 CF.sub.3 -- (S)-isomer 590
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q7
CH.sub.3 CHF.sub.2 -- 591 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q7 CH.sub.3 CHF.sub.2 -- 592
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q7
CH.sub.3 CHF.sub.2 -- 99-101 593
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q7 CH.sub.3 CHF.sub.2 -- 83-94 594 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q14 H COCF.sub.3 H *** (S)-isomer 595
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q14 I
COCF.sub.3 H *** (S)-isomer 596 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q14 C.sub.2F.sub.5 COCF.sub.3 H ***
(S)-isomer 597 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 --
0 Q1 H H C.sub.3F.sub.7-n 598 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 -- 0 Q1 H H C.sub.4F.sub.9-n 599
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q1 H H
C.sub.6F.sub.13-n 600 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 -- 0 Q1 H H C.sub.8F.sub.17-n 601
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H H
C.sub.3F.sub.7-n (S)-isomer 602 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.4F.sub.9-n 69-72 (S)-isomer 603
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H H
C.sub.6F.sub.13-n (S)-isomer 604 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.8F.sub.17-n (S)-isomer 605
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CH.sub.3 H C.sub.3F.sub.7-n 606 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 CH.sub.3 H C.sub.4F.sub.9-n 607
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CH.sub.3 H C.sub.6F.sub.13-n 608 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 CF.sub.3 H 74-78 (S)-isomer
609 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 CF.sub.3 H 176-177 (S)-isomer 610
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 CF.sub.3 H 81-87 (S)-isomer 611
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 CF.sub.3 H (S)-isomer 612
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 CF.sub.3 H (S)-isomer 613
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 CF.sub.3 H (S)-isomer 614
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n CF.sub.3 H (S)-isomer 615
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n CF.sub.3 H (S)-isomer 616
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n CF.sub.3 H (S)-isomer 617
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n CF.sub.3 H (S)-isomer 618
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n CF.sub.3 H (S)-isomer 619
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q1
C.sub.3F.sub.7-n CF.sub.3 H (S)-isomer 620
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H 621
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H 622
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 C.sub.2F.sub.5 C.sub.2F.sub.5 H 623
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H 624
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H 625
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q1 C.sub.2F.sub.5 C.sub.2F.sub.5 H 626
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H *** (S)-isomer 627
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H (S)-isomer 628
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H (S)-isomer 629
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H (S)-isomer 630
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H (S)-isomer 631
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H (S)-isomer 632
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3
H Cl *** (S)-isomer 633 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 H Cl *** (S)-isomer 634
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H Cl *** (S)-isomer 635
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H Br *** (S)-isomer 636 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 H I *** (S)-isomer 637
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.2F.sub.5 73-78 (S)-isomer 638
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.2F.sub.5 81-84 (S)-isomer 639
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.2F.sub.5 87-90 (S)-isomer 640
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3
H C.sub.2F.sub.5 *** (S)-isomer 641 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 H C.sub.2F.sub.5 164-166
(S)-isomer 642 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3
CH.sub.2 1 Q1 CF.sub.3 H C.sub.2F.sub.5 75-85 (S)-isomer 643
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.3F.sub.7-n 73-75 (S)-isomer 644
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3
H C.sub.3F.sub.7-n 86-88 (S)-isomer 645
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.4F.sub.9-n 79-82 (S)-isomer 646
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.4F.sub.9-n 73-76 (S)-isomer 647
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.4F.sub.9-n 83-88 (S)-isomer 648
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3
H C.sub.4F.sub.9-n 88-92 (S)-isomer 649
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.4F.sub.9-n 84-90 (S)-isomer 650
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.4F.sub.9-n 75-78 (S)-isomer 651
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 *** (S)-isomer 652
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 124-125 (S)-isomer 653
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 88-91 (S)-isomer 654
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 *** (S)-isomer 655
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 87-92 (S)-isomer 656
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 100-107 (S)-isomer 657
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n 64-65 (S)-isomer 658
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n *** (S)-isomer 659
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n 78-81 (S)-isomer 660
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n *** (S)-isomer 661
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n 83-85 (S)-isomer 662
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n 92-96 (S)-isomer 663
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.4F.sub.9-n 72-74 (S)-isomer 664
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.4F.sub.9-n 84-88 (S)-isomer 665
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 78-85 (S)-isomer 666
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 78-85 (S)-isomer 667
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 70-74 (S)-isomer 668
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 73-77 (S)-isomer 669
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 77-82 (S)-isomer 670
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 86-90 (S)-isomer 671
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 81-84 (S)-isomer 672
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 147-148 (S)-isomer 673
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H
C.sub.2F.sub.5 CF.sub.3 (S)-isomer 674
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H
C.sub.2F.sub.5 CF.sub.3 (S)-isomer 675
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H
C.sub.2F.sub.5 C.sub.2F.sub.5 *** (S)-isomer 676
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H
C.sub.2F.sub.5 C.sub.2F.sub.5 (S)-isomer 677
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 678
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 679
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- 680
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 681 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- ***
(S)-isomer 682 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3
CH.sub.2 1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- 683
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 162-164 (S)-isomer 684
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 685
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 103-106 (S)-isomer 686
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 687
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 688
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2
1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 689
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 690
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 691
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2
1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- 692
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 693 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 --
(S)-isomer 694 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3
CH.sub.2 1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- 695
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 696
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 697
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 698
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 699
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 700
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Br 2-CH.sub.3 CH.sub.2
1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 701
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 702
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 703
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- 704
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 705 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 --
(S)-isomer 706 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3
CH.sub.2 1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- 707
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 708
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 709
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 710
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer
711 CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1
Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 712
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2
1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 713
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.3F.sub.7-n CF.sub.3 -- 714 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q2 C.sub.3F.sub.7-n CF.sub.3 -- ***
(S)-isomer 715 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3
CH.sub.2 1 Q2 C.sub.3F.sub.7-n CF.sub.3 -- (S)-isomer 716
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.3F.sub.7-n C.sub.2F.sub.5 -- (S)-isomer 717
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.3F.sub.7-n C.sub.2F.sub.5 -- (S)-isomer 718
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-F 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 719 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-F
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 720
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-F 2-CH.sub.3 CH.sub.2 1
Q1 CF.sub.3 CF.sub.3 H 721 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-F
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 722
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-F 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 723 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H H C.sub.4F.sub.9-n 63-69 (S)-isomer
724 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1
Q1 H H C.sub.4F.sub.9-n 95-97 (S)-isomer 725
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H
CF.sub.3 C.sub.3F.sub.7-n 76-81 (S)-isomer 726
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H
CF.sub.3 C.sub.3F.sub.7-n *** (S)-isomer 727
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
H CF.sub.3 C.sub.3F.sub.7-n *** (S)-isomer 728
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 H
C.sub.2F.sub.5 C.sub.2F.sub.5 68-72 (S)-isomer 729
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
H C.sub.2F.sub.5 C.sub.2F.sub.5 *** (S)-isomer 730
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CHF.sub.2 CHF.sub.2 H *** (S)-isomer 731
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H CF.sub.3 732 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 H CF.sub.3 (S)-isomer 733
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H CF.sub.2CHF.sub.2 734 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 H CF.sub.2CHF.sub.2 (S)-isomer
735 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1
Q1 CF.sub.3 H C.sub.4F.sub.9-n 736 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 H C.sub.4F.sub.9-n 737
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.6F.sub.13-n 78-82 (S)-isomer 738
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.8F.sub.17-n 79-82 (S)-isomer 739
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 CF.sub.3 (S)-isomer 740
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.2CHF.sub.2 H C.sub.2F.sub.5 741
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.2CHF.sub.2 H C.sub.2F.sub.5 *** (S)-isomer 742
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.2CHF.sub.2 H C.sub.2F.sub.5 64-67 (S)-isomer 743
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.2CHF.sub.2 H C.sub.2F.sub.5 83-89 (S)-isomer 744
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H CF.sub.3 745 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 H CF.sub.3 75-80 (S)-isomer
746 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H CF.sub.2CHF.sub.2 (S)-isomer 747
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H CF.sub.2CHF.sub.2 (S)-isomer 748
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H CF.sub.2CHF.sub.2 (S)-isomer 749
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 750
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 751
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 752
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 753 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 754
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 755 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Cl 2-CH.sub.3 -- 0 Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 95-100
(S)-isomer 756 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3
CH(CH.sub.3) 1 Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 (S)-isomer 757
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 89-94 (S)-isomer 758
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 (S)-isomer 759
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 195-195 (S)-isomer 760
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1
Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 (S)-isomer 761
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 70-74 (S)-isomer 762
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 79-84 (S)-isomer 763
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 185-188 (S)-isomer 764
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1
Q1 C.sub.2F.sub.5 H C.sub.3F.sub.7-n 765
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n 766
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n 767
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 C.sub.2F.sub.5 H C.sub.3F.sub.7-n 768
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n 769
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.4F.sub.9-n 770 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 H C.sub.4F.sub.9 771
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.4F.sub.9-n 81-85 (S)-isomer 772
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.4F.sub.9-n (S)-isomer 773
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 F CF.sub.3 774 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 F CF.sub.3 775
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 F CF.sub.3 142-146 (S)-isomer 776
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 F CF.sub.3 (S)-isomer 777
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 F CF.sub.3 (S)-isomer 778
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 CH.sub.3 C.sub.2F.sub.5 *** (S)-isomer 779
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 C.sub.2F.sub.5 (S)-isomer 780
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 781
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 782
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 C.sub.3F.sub.7-n H C.sub.2F.sub.5 783
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 784
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 81-83 (S)-isomer 785
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 85-90 (S)-isomer 786
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH(CH.sub.3) 1
Q1 C.sub.3F-n H C.sub.3F.sub.7-n 787
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F-n H C.sub.3F.sub.7-n 788
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F-n H C.sub.3F.sub.7-n 789
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 C.sub.3F-n H C.sub.3F.sub.7-n 790
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F-n H C.sub.3F.sub.7-n 791 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 C.sub.3F-n H C.sub.3F.sub.7-n 792
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F-n H C.sub.3F.sub.7-n 793 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 C.sub.3F.sub.7-n C.sub.3F.sub.7-n H
74-78 (S)-isomer 794 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3
CH.sub.2 1 Q1 C.sub.3F.sub.7-n C.sub.3F.sub.7-n H 72-76 (S)-isomer
795 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1
Q1 C.sub.3F.sub.7-n C.sub.3F.sub.7-n H 149-150 (S)-isomer 796
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CHFCF.sub.3 CF.sub.3 -- 66-69 (S)-isomer 797
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CHFCF.sub.3 CF.sub.3 -- 80-85 (S)-isomer 798
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CHFCF.sub.3 CF.sub.3 -- 81-86 (S)-isomer 799
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.2CHF.sub.2 CF.sub.2CHF.sub.2 -- *** (S)-isomer 800
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.2CHF.sub.2 CF.sub.2CHF.sub.2 -- 159-163 (S)-isomer 801
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
CF.sub.2CHF.sub.2 CF.sub.2CHF.sub.2 -- 77-83 (S)-isomer 802
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.3F.sub.7-n C.sub.3F.sub.7-n -- 803
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.4F.sub.9-n H -- 218-210 (S)-isomer 804
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q2
SC.sub.3F.sub.7-n CF.sub.3 -- 73-76 (S)-isomer 805
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q6
CF.sub.3 CF.sub.3 CF.sub.3 (S)-isomer 806
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q6
CF.sub.3 CF.sub.3 CF.sub.3 (S)-isomer
807 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1
Q6 CF.sub.3 CF.sub.3 CF.sub.3 (S)-isomer 808
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- 809 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3 CF.sub.3 -- 810
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q9 CF.sub.3 CF.sub.3 -- 811 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3 CF.sub.3 -- 812
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- 813 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3 CF.sub.3 -- 814
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- (S)-isomer 815
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- (S)-isomer 816
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- (S)-isomer 817
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- (S)-isomer 818
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2
1 Q9 CF.sub.3 CF.sub.3 -- (S)-isomer 819
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- 820 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q9 C.sub.2F.sub.5 CF.sub.3 -- 821
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q9 C.sub.2F.sub.5 CF.sub.3 -- 822 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q9 C.sub.2F.sub.5 CF.sub.3 -- 823
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- 824 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q9 C.sub.2F.sub.5 CF.sub.3 -- 825
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 826
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 827
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 828
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 829
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 830
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-Cl 2-CH.sub.3 CH.sub.2
1 Q9 C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 831
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 832 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q9 C.sub.2F.sub.5 C.sub.2F.sub.5 -- 833
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 834
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.3F.sub.7-n CF.sub.3 -- 835 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q9 C.sub.3F.sub.7-n CF.sub.3 -- (S)-isomer
836 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 S 1 Q18 CF.sub.3
CH.sub.3 -- (S)-isomer 837 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q19 CF.sub.3 CH.sub.3 -- (S)-isomer 838
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q17
CF.sub.3 H -- 839 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3
CH.sub.2 1 Q15 H C.sub.2F.sub.5 -- 840
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q15 H
C.sub.2F.sub.5 -- 71-75 (S)-isomer 841
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 -- 0 Q20 CF.sub.3 --
-- (S)-isomer 842 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 --
0 Q16 C.sub.2F.sub.5 -- -- 843 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 -- 0 Q16 C.sub.3F.sub.7-n -- -- 844
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.2F.sub.5 845 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 H C.sub.4F.sub.9-n 846
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.4F.sub.9-n 847 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.2CHF.sub.2 H C.sub.2F.sub.5
848 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1
Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 849
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 850
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2
1 Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 851
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 852 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 853
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 854
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.4F.sub.9-n 855 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 H C.sub.4F.sub.9-n 856
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 857
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 858
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 859
CH(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2
1 Q1 C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 860
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 861
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 862
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 863
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- 864 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3 CF.sub.3 -- 865
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2
1 Q9 CF.sub.3 CF.sub.3 -- 866 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3 CF.sub.3 -- 867
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- 868 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Br
2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3 CF.sub.3 -- 869
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- 870 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q9 C.sub.2F.sub.5 CF.sub.3 -- 871
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Br 2-CH.sub.3 CH.sub.2
1 Q9 C.sub.2F.sub.5 CF.sub.3 -- 872 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q9 C.sub.2F.sub.5 CF.sub.3 -- 873
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Br 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- 874 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-Br 2-CH.sub.3 CH.sub.2 1 Q9 C.sub.2F.sub.5 CF.sub.3 -- 875
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H H
C.sub.4F.sub.9-n 80-85 (S)-isomer 876
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H H
C.sub.4F.sub.9-n 160-162 (S)-isomer 877
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 H
H C.sub.4F.sub.9-n 85-89 (S)-isomer 878
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CHF.sub.2 CHF.sub.2 H *** (S)-isomer 879
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H CF.sub.3 880 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 H CF.sub.2CHF.sub.2 881
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3
H CF.sub.2CHF.sub.2 (S)-isomer 882
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.2F.sub.5 883 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 H C.sub.2F.sub.5 884
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 H C.sub.4F.sub.9-n 885 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 H C.sub.4F.sub.9-n 886
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 CF.sub.3 887 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 CF.sub.3 888
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q1
CF.sub.2CHF.sub.2 H C.sub.2F.sub.5 889
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.2CHF.sub.2 H C.sub.2F.sub.5 890
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.2CHF.sub.2 H C.sub.2F.sub.5 (S)-isomer 891
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.2CHF.sub.2 H C.sub.2F.sub.5 (S)-isomer 892
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.2CHF.sub.2 H C.sub.2F.sub.5 (S)-isomer 893
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H CF.sub.3 894 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 H CF.sub.2CHF.sub.2
(S)-isomer 895 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3
CH.sub.2 1 Q1 C.sub.2F.sub.5 H CF.sub.2CHF.sub.2 (S)-isomer 896
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H CF.sub.2CHF.sub.2 (S)-isomer 897
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 898
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 899
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 900
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 901
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 902 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 903
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 904
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 (S)-isomer 905
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 (S)-isomer 906
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2
1 Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 (S)-isomer 907
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n 908
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n 909
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q1 C.sub.2F.sub.5 H C.sub.3F.sub.7-n 910
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n 911
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.4F.sub.9-n 912 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 H C.sub.4F.sub.9-n 913
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.4F.sub.9-n 90-96 (S)-isomer 914
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.4F.sub.9-n 92-97 (S)-isomer 915
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 F CF.sub.3
916 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 917 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 C.sub.3F.sub.7-n H C.sub.2F.sub.5 918
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 919
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 920
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 89-96 (S)-isomer 921
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.2F.sub.5 92-96 (S)-isomer 922
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 923
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 924
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q1 C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 925
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 926
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 927
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.3F.sub.7-n H C.sub.3F.sub.7-n 928
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q2
C.sub.3F.sub.7-n C.sub.3F.sub.7-n -- 929
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q6 CF.sub.3
CF.sub.3 CF.sub.3 (S)-isomer 930 CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q6 CF.sub.3 CF.sub.3 CF.sub.3 (S)-isomer 931
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q6
CF.sub.3 CF.sub.3 CF.sub.3 (S)-isomer 932
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q9
CF.sub.3 CF.sub.3 -- 933 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3 CF.sub.3 -- 934
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- 935 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q9 CF.sub.3 CF.sub.3 -- 936
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- (S)-isomer 937
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- (S)-isomer 938
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- (S)-isomer 939
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q9
CF.sub.3 CF.sub.3 -- (S)-isomer 940
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2
1 Q9 CF.sub.3 CF.sub.3 -- (S)-isomer 941
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- 942 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q9 C.sub.2F.sub.5 CF.sub.3 -- 943
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- 944
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q9 C.sub.2F.sub.5 CF.sub.3 -- 945 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q9 C.sub.2F.sub.5 CF.sub.3 -- 946
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- 947 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q9 C.sub.2F.sub.5 CF.sub.3 -- 948
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 949
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 950
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 951
CH(CH.sub.3)CH.sub.2SC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 952
CH(CH.sub.3)CH.sub.2SOC.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 953
CH(CH.sub.3)CH.sub.2SO.sub.2C.sub.2H.sub.5 3-I 2-CH.sub.3 CH.sub.2
1 Q9 C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 954
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH(CH.sub.3) 1 Q9
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 955
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 C.sub.2F.sub.5 -- 956 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q9 C.sub.2F.sub.5 C.sub.2F.sub.5 -- 957
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 958
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q9
C.sub.3F.sub.7-n CF.sub.3 -- 959 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 CH.sub.2 1 Q9 C.sub.3F.sub.7-n CF.sub.3 -- (S)-isomer
960 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 S 1 Q18
CF.sub.3 CH.sub.3 -- 961 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I
2-CH.sub.3 -- 0 Q19 CF.sub.3 CH.sub.3 -- 962
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q17
CF.sub.3 H -- 963 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3
CH.sub.2 1 Q15 H C.sub.2F.sub.5 -- 964
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q20 CF.sub.3
-- -- 965 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 -- 0 Q16
CF.sub.3 -- -- 966 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-F
CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 967
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl 2-F CH.sub.2 1 Q1 CF.sub.3
CF.sub.3 H 968 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-F
CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 969
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 970 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 971
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2
1 Q1 CF.sub.3 CF.sub.3 H 972 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 973
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 974 CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl
2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 975
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 976 CH(CH.sub.3)CH.sub.2SOCH.sub.3
3-Cl 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H (S)-isomer 977
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H (S)-isomer 978 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-Cl 2-Cl CH.sub.2 1 Q1 C.sub.2F.sub.5 CF.sub.3 H (S)-isomer 979
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 CF.sub.3 H (S)-isomer 980
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 CF.sub.3 H (S)-isomer 981
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q1 CF.sub.3
H C.sub.2F.sub.5 982 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-Cl
CH.sub.2 1 Q1 CF.sub.3 H C.sub.3F.sub.7-n 983
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q1 CF.sub.3
H C.sub.4F.sub.9-n 984 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-Cl 2-Cl
CH.sub.2 1 Q1 CF.sub.3 H C.sub.6F.sub.13-n 985
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 (S)-isomer 986
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 (S)-isomer 987
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.2F.sub.5 (S)-isomer 988
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n (S)-isomer 989
CH(CH.sub.3)CH.sub.2SOCH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n (S)-isomer 990
CH(CH.sub.3)CH.sub.2SO.sub.2CH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n (S)-isomer 991
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q2 CF.sub.3
CF.sub.3 -- (S)-isomer 992 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-Cl
CH.sub.2 1 Q2 C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 993
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-Cl CH.sub.2 1 Q9 CF.sub.3
CF.sub.3 -- (S)-isomer 994 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-Cl 2-Cl
CH.sub.2 1 Q9 C.sub.2F.sub.5 CF.sub.3 -- (S)-isomer 995
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-F CH.sub.2 1 Q1 CF.sub.3
CF.sub.3 H *** 996 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-F
CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 997
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-F CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 113-115 998 C(CH.sub.3).sub.2CH.sub.2SCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 157-159 999
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
CF.sub.3 CF.sub.3 H 1000 C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 CF.sub.3 CF.sub.3 H 129-134 1001
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1 Q1
C.sub.2F.sub.5 CF.sub.3 H 1002 C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3
3-I 2-CH.sub.3 CH.sub.2 1 Q1 C.sub.2F.sub.5 CF.sub.3 H 1003
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-CH.sub.3 CH.sub.2 1
Q1 C.sub.2F.sub.5 CF.sub.3 H 1004
C(CH.sub.3).sub.2CH.sub.2SCH.sub.3 3-I 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H 1005
C(CH.sub.3).sub.2CH.sub.2SOCH.sub.3 3-I 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H 1006
C(CH.sub.3).sub.2CH.sub.2SO.sub.2CH.sub.3 3-I 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 C.sub.2F.sub.5 H 1007 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-Cl CH.sub.2 1 Q1 C.sub.2F.sub.5 H C.sub.2F.sub.5 (S)-isomer
1008 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-Cl CH.sub.2 1 Q1
C.sub.2F.sub.5 H C.sub.3F.sub.7-n (S)-isomer 1009
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-Cl CH.sub.2 1 Q1 C.sub.2F.sub.5
H C.sub.4F.sub.9-n (S)-isomer 1010 CH(CH.sub.3)CH.sub.2SCH.sub.3
3-I 2-Cl CH.sub.2 1 Q1 C.sub.2F.sub.5 H C.sub.6F.sub.13-n
(S)-isomer 1011 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-Cl CH.sub.2 1
Q2 CF.sub.3 CF.sub.3 -- (S)-isomer 1012
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-Cl CH.sub.2 1 Q2 C.sub.2F.sub.5
CF.sub.3 -- (S)-isomer 1013 CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-Cl
CH.sub.2 1 Q2 C.sub.2F.sub.5 C.sub.2F.sub.5 -- (S)-isomer 1014
CH(CH.sub.3)CH.sub.2SCH.sub.3 3-I 2-Cl CH.sub.2 1 Q2
C.sub.3F.sub.7-n CF.sub.3 -- (S)-isomer indicates data missing or
illegible when filed
TABLE-US-00002 TABLE 2 No. 1 1H-NMR (CDCl3, ppm): 1.4 (6H, s), 2.0
(3H, s), 2.3 (3H, s), 2.9 (2H, s), 5.4 (2H, s), 6.2 (1H, s), 6.9
(1H, s), 7.3-8.7 (8H, m) 3 1H-NMR (CDCl3, ppm): 1.5 (6H, s), 2.2
(3H, s), 2.6 (3H, s), 3.7 (2H, s), 5.4 (2H, s), 6.4 (1H, s), 6.9
(1H, s), 7.3-8.2 (8H, m) 8 1H-NMR (CDCl3, ppm): 1.4 (6H, s), 2.0
(3H, s), 2.3 (3H, s), 2.9 (2H, s), 5.4 (2H, s), 6.1 (1H, s), 6.9
(1H, s), 7.3-8.4 (7H, m) 11 1H-NMR (CDCl3, ppm): 1.2 (3H, d), 1.9
(3H, s), 2.3 (3H, s), 2.7 (2H, dd), 4.2 (1H, m), 5.4 (2H, s), 6.4
(1H, d), 6.9 (1H, s), 7.3-8.4 (7H, m) 15 1H-NMR (CDCl3, ppm): 1.3
(3H, d), 2.2 (3H, s), 2.8 (3H, s), 3.2 (2H, m), 4.6 (1H, m), 5.4
(2H, s), 6.4 (1H, d), 6.9-8.4 (8H, m) 47 1H-NMR (CDCl3, ppm): 1.6
(6H, s), 2.3 (3H, s), 2.5 (3H, s), 3.5 (2H, s), 5.4 (2H, s), 6.6
(1H, s), 6.9 (1H, s), 7.3-8.2 (7H, m) 52 1H-NMR (CDCl3, ppm): 1.4
(3H, d), 2.2 (3H, s), 2.7 (3H, s), 3.2 (2H, m), 4.4 (1H, m), 5.4
(2H, s), 6.9-8.2 (9H, m) 81 1H-NMR (CDCl3, ppm): 1.1 (6H, d), 2.2
(3H, s), 4.2 (1H, m), 5.3 (2H, s), 5.9 (1H, d), 6.9-8.2 (8H, m) 83
1H-NMR (CDCl3, ppm): 1.57 (3H, s), 1.60 (3H, s), 2.20 (3H, s), 2.30
(3H, s), 2.93 (2H, dd), 5.43 (2H, s), 6.57 (1H, s), 6.90 (1H, s),
7.0-8.2 (7H, m) 85 1H-NMR (CDCl3, ppm): 1.2 (3H, d), 1.8 (3H, s),
2.2 (3H, s), 2.6 (2H, dd), 4.2 (1H, m), 5.3 (2H, s), 6.5 (1H, d),
6.9 (1H, s), 7.3-8.4 (7H, m) 89 1H-NMR (CDCl3, ppm): 1.4 (3H, d),
2.2 (3H, s), 2.7 (3H, s), 3.2 (2H, m), 4.5 (1H, m), 5.3 (2H, s),
6.6 (1H, d), 6.9-7.9 (8H, m) 94 1H-NMR (CDCl3, ppm): 1.57 (3H, s),
1.60 (3H, s), 2.20 (3H, s), 2.30 (3H, s), 2.93 (2H, dd), 5.43 (2H,
s), 6.57 (1H, s), 6.90 (1H, s), 7.0-8.2 (7H, m) 96 1H-NMR (CDCl3,
ppm): 1.63 (6H, s), 2.27 (3H, s), 2.50 (3H, s), 3.47 (2H, s), 5.30
(2H, s), 6.23 (1H, s), 6.57 (1H, s), 7.0-8.1 (8H, m) 97 1H-NMR
(CDCl3, ppm): 1.27 (3H, d), 1.93 (3H, s), 2.30 (3H, s), 2.63 (2H,
m), 4.33 (1H, m), 5.37 (2H, s), 6.07 (1H, m), 6.60 (1H, s), 6.9-8.2
(8H, m) 99 1H-NMR (CDCl3, ppm): 1.50 (3H, d), 2.27 (3H, s), 2.70
(3H, s), 3.0-3.5 (2H, m), 4.60 (1H, m), 5.37 (2H, s), 6.5-8.0 (10H,
m) 103 1H-NMR (CDCl3, ppm): 1.27 (3H, d), 1.93 (3H, s), 2.30 (3H,
s), 2.60 (2H, m), 4.33 (1H, m), 5.20 (2H, s), 6.17 (1H, s), 6.47
(1H, t), 7.1-8.3 (8H, m) 107 1H-NMR (CDCl3, ppm): 1.50 (3H, d),
1.93 (3H, s), 2.30 (3H, s), 2.60 (2H, m), 4.33 (1H, m), 5.20 (2H,
s), 6.17 (1H, s), 6.47 (1H, t), 6.67 (1H, m), 7.0-8.1 (7H, m) 116
1H-NMR (CDCl3, ppm): 1.2 (3H, d), 1.9 (3H, s), 2.2 (3H, s), 2.6
(2H, dd), 4.2 (1H, m), 5.2 (2H, s), 6.4 (1H, d), 7.0-8.3 (9H, m)
149 1H-NMR (CDCl3, ppm): 1.34 (6H, s), 1.95 (3H, s), 2.33 (3H, s),
2.86 (2H, s), 5.48 (2H, s), 6.11 (1H, s), 7.56-7.00 (4H, m),
7.84-7.72 (1H, m), 8.23 (1H, d), 8.49 (1H, s) 153 1H-NMR (CDCl3,
ppm): 1.22 (3H, d), 2.05 (3H, s), 2.30 (3H, s), 2.61-2.53 (2H, m),
4.40-4.29 (1H, m), 5.44 (2H, s), 6.19 (1H, d), 7.17 (2H, t),
7.54-7.48 (2H, m), 7.73 (1H, d), 8.15 (1H, d), 8.44 (1H, s) 180
1H-NMR (CDCl3, ppm): 1.3 (3H, d), 2.2 (3H, s), 2.3 (3H, s), 2.8
(2H, d), 4.5 (1H, m), 5.4 (2H, s), 7.1-8.3 (8H, m) 242 1H-NMR
(CDCl3, ppm): 1.4 (3H, d), 2.2 (3H, s), 2.8 (3H, s), 3.2 (2H, m),
4.6 (1H, m), 5.5 (2H, s), 6.2-8.2 (9H, m) 251 1H-NMR (CDCl3, ppm):
1.25 (3H, d), 1.95 (3H, s), 2.28 (3H, s), 2.63-2.51 (2H, m), 3.28
(3H, s), 4.36-4.26 (1H, m), 5.43 (2H, s), 6.38 (1H, d, J = 9.3 Hz),
7.39-7.16 (2H, m), 7.62-7.53 (2H, m), 7.81-7.74 (1H, m), 8.38 (1H,
s) 271 1H-NMR (CDCl3, ppm): 1.47 (6H, s), 2.00 (3H, s), 2.30 (3H,
s), 2.83 (2H, s), 3.30 (1H, m), 4.2-4.6 (4H, m), 6.07 (1H, s),
7.1-8.2 (7H, m) 277 1H-NMR (CDCl3, ppm): 1.1 (6H, d), 2.2 (3H, s),
4.1 (1H, m), 5.0 (2H, s), 6.0 (1H, d), 7.0-8.4 (8H, m) 417 1H-NMR
(CDCl3, ppm): 1.5 (3H, d), 2.3 (3H, s), 2.8 (3H, s), 3.2 (2H, dd),
4.7 (1H, m), 6.5 (1H, m), 7.0 (1H, s), 7.3-8.3 (6H, m) 422 1H-NMR
(CDCl3, ppm): 1.47 (6H, s), 2.03 (3H, s), 2.40 (3H, s), 2.87 (2H,
s), 6.03 (1H, s), 6.80 (1H, m), 7.1-8.6 (8H, m) 434 1H-NMR (CDCl3,
ppm): 1.40 (6H, s), 2.03 (3H, s), 2.40 (3H, s), 2.87 (2H, s), 6.07
(1H, s), 6.77 (1H, m), 7.2-8.5 (8H, m) 521 1H-NMR (CDCl3, ppm):
1.23 (3H, d), 1.90 (3H, s), 2.26 (3H, s), 2.50-2.67 (2H, m),
4.10-4.50 (1H, m), 5.37 (2H, s), 6.15 (1H, d), 6.60 (1H, bs),
6.90-7.20 (3H, m), 7.57 (1H, bs), 7.70 (1H, d), 7.80-8.23 (3H, m)
522 1H-NMR (CDCl3, ppm): 1.50 (3H, d), 2.30 (3H, s), 2.70 (3H, s),
2.97-3.50 (2H, m), 4.56 (1H, m), 5.43 (2H, s), 6.60-8.03 (10H, m)
523 1H-NMR (CDCl3, ppm): 1.40 (6H, s), 1.98 (3H, s), 2.30 (3H, s),
2.73 (2H, s), 5.40 (2H, s), 6.03 (1H, bs), 6.60-7.20 (4H, m),
7.50-8.20 (5H, m) 529 1H-NMR (CDCl3, ppm): 1.42 (6H, s), 1.98 (3H,
s), 2.30 (3H, s), 2.71 (2H, s), 5.30 (2H, s), 6.03 (1H, bs), 6.52
(1H, d), 7.03-7.35 (4H, m), 7.73 (1H, d), 7.93 (1H, d), 8.10-8.40
(2H, m) 530 1H-NMR (CDCl3, ppm): 1.63 (6H, s), 2.30 (3H, s), 2.57
(3H, s), 3.47 (2H, s), 5.30 (2H, s), 6.40 (1H, bs), 6.57 (1H, d),
7.03-8.17 (8H, m) 532 1H-NMR (CDCl3, ppm): 1.30 (4H, dd), 1.97 (3H,
s), 2.28 (3H, s), 2.73-2.42 (2H, m), 4.37-4.28 (1H, m), 5.28 (2H,
s), 6.42 (1H, d), 6.55 (1H, d), 7.09 (2H, t), 7.42-7.39 (2H, m),
7.51 (1H, d), 7.70 (1H, t), 8.02 (1H, d), 8.49 (1H, d) 534 1H-NMR
(CDCl3, ppm): 1.24 (3H, d), 1.93 (3H, s), 2.30 (3H, s), 2.50-2.66
(2H, m), 4.23-4.40 (1H, m), 5.32 (2H, s), 6.16 (1H, d), 6.54 (1H,
d), 7.06 (1H, bs), 7.11 (1H, d), 7.22 (1H, t), 7.40 (1H, d), 7.78
(1H, d), 7.97 (1H, d), 8.17 (1H, d), 8.30 (1H, bs) 536 1H-NMR
(CDCl3, ppm): 1.50 (3H, d), 2.28 (3H, s), 2.73 (3H, s), 2.97-3.50
(2H, m), 4.60 (1H, m), 5.30 (2H, s), 6.53 (1H, d), 6.73 (1H, d),
7.00-8.07(8H, m) 537 1H-NMR (CDCl3, ppm): 1.40(6H, s), 1.98 (3H,
s), 2.31 (3H, s), 2.81 (2H, s), 5.32 (2H, s), 6.08 (1H, bs), 6.54
(1H, d), 7.04 (1H, bs) 7.11 (1H, d), 7.20 (1H, t), 7.38 (1H, d),
7.79 (1H, d), 7.96 (1H, d), 8.22 (1H, d), 8.38 (1H, bs) 538 1H-NMR
(CDCl3, ppm): 1.66(6H, s), 2.30 (3H, s), 2.60 (3H, s), 3.52 (2H,
s), 5.30 (2H, s), 6.47 (1H, bs), 6.57 (1H, d), 7.03-8.23 (8H, m)
550 1H-NMR (CDCl3, ppm): 1.48 (6H, d), 2.21 (3H, s), 2.48 (3H, s),
4.13 (1H, m), 5.42 (2H, s), 6.18(1H, d), 6.91 (1H, s), 7.1-7.6 (6H,
m), 8.08 (1H, d) 552 1H-NMR (CDCl3, ppm): 1.17 (3H, d), 1.89 (3H,
s), 2.29 (3H, s), 2.42 (1H, dd), 2.60 (1H, dd), 3.29 (3H, s), 4.24
(1H, m), 5.42 (2H, s), 6.41 (1H, d), 6.92 (1H, s), 7.1-7.2 (2H, m).
7.6-8.2 (5H, m) 553 1H-NMR (CDCl3, ppm): 1.21 (3H, d), 1.32 (3H,
t), 1.95 (3H, s), 2.29 (3H, s), 2.51 (1H, dd), 2.60 (1H, dd), 3.00
(2H, q), 4.31 (1H, m), 5.41 (2H, s), 6.28 (1H, d), 6.91 (1H, s),
7.1-7.2 (2H, m), 7.4-7.6 (3H, m), 8.09 (1H, d), 8.34 (1H, s) 554
1H-NMR (CDCl3, ppm): 1.25 (5H, dd), 1.91 (3H, s), 2.29 (3H, s),
2.60-2.54 (2H, m), 4.32-4.27 (1H, m), 5.44 (2H, s), 6.40 (1H, d),
7.06 (2H, d, J = 7.5 Hz), 7.19-7.12 (1H, m), 7.71 (1H, d),
7.94-7.91 (1H, m), 8.08 (1H, d), 8.36 (1H, s) 569 1H-NMR (CDCl3,
ppm): 8.50 (1H, m), 7.95 (1H, m), 7.79-7.49 (4H, m), 7.44-7.38 (1H,
m), 7.22 (1H, m), 5.75 (1H, q), 4.38 (1H, m), 2.79 (2H, m), 2.29
(3H, s), 2.20 (3H, s), 2.00 (3H, d), 1.43-1.18 (3H, d) 574 1H-NMR
(CDCl3, ppm): 1.31 (3H, d), 1.95 (3H, s), 2.30 (3H, s), 2.61-2.57
(2H, m), 4.37-4.27 (1H, m), 5.79-5.73 (1H, m), 6.48 (1H, d), 7.02
(1H, s), 7.25-7.21 (2H, m), 7.52-7.36 (3H, m), 7.84-7.69 (2H, m),
8.04 (1H, d), 8.50 (1H, s) 594 1H-NMR (CDCl3, ppm): 1.22 (3H, d),
1.93 (3H, s), 2.26 (3H, s), 2.61-2.55 (2H, m), 4.36-4.27 (1H, m),
5.49 (2H, d), 6.07 (1H, d), 6.34-6.30 (1H, m), 6.98 (2H, d), 7.13
(1H, t), 7.27-7.22 (3H, m), 7.79 (1H, d), 7.97 (1H, dd), 8.08 (1H,
d), 8.23 (1H, s) 595 1H-NMR (CDCl3, ppm): 1.25 (3H, d), 1.94 (3H,
s), 2.27 (3H, s), 2.60-2.54 (2H, m), 4.34-4.25 (1H, m), 5.49 (2H,
d), 6.42 (1H, d), 7.04-6.99 (2H, m), 7.21-7.14 (2H, m), 7.35-7.32
(1H, m), 7.72 (1H, d), 7.93 (1H, dd), 8.05 (1H, d), 8.36 (1H, s)
596 1H-NMR (CDCl3, ppm): 1.24 (3H, d), 1.97 (3H, s), 2.33 (3H, s),
2.63-2.54 (2H, m), 4.35-4.30 (1H, m), 5.52 (2H, s), 6.05 (1H, d),
7.02-7.00 (2H, m), 7.26-7.21 (1H, m), 7.35-7.32 (1H, m), 7.42-7.39
(1H, m), 7.80 (1H, t), 7.98 (1H, d), 8.18 (1H, t), 8.32 (1H, d) 626
1H-NMR (CDCl3, ppm): 1.22 (3H, d), 1.92 (3H, s), 2.30 (3H, s), 2.54
(1H, dd), 2.61 (1H, dd), 4.32 (1H, m), 5.46 (2H, s), 6.23 (1H, m),
6.94 (1H, s), 7.0-7.1 (2H, m), 7.45 (1H, m), 7.54 (1H, d), 7.72
(1H, d), 8.07 (1H, d), 8.38 (1H, bs) 632 1H-NMR (CDCl3, ppm): 1.26
(3H, dd), 1.96 (3H, s), 2.32 (3H, s), 2.61-2.55 (2H, m), 4.34-4.29
(1H, m), 5.22 (2H, s), 6.22 (1H, d), 7.21-7.13 (3H, m), 7.36 (1H,
d), 7.78 (1H, d), 7.97 (1H, dd), 8.16 (1H, d), 8.35 (1H, s) 633
1H-NMR (CDCl3, ppm): 1.23 (3H, dd), 1.97 (3H, s), 2.31 (3H, s),
2.61-2.56 (2H, m), 4.37-4.32 (1H, m), 5.25 (2H, s), 6.13 (1H, d),
7.11 (2H, dd), 7.37 (1H, t), 7.48 (1H, dd), 7.61-7.53 (1H, m), 7.79
(1H, dt), 8.15 (1H, d), 8.43 (1H, d) 634 1H-NMR (CDCl3, ppm): 1.25
(4H, dd), 1.98 (3H, s), 2.33 (3H, s), 2.61-2.56 (2H, m), 8.41 (1H,
s), 4.38-4.31 (1H, m), 5.24 (2H, s), 6.17 (1H, d), 7.13-7.11 (2H,
m), 7.38 (1H, s), 7.46 (1H, t), 7.56 (1H, dd), 7.79 (1H, t), 8.14
(1H, d) 635 1H-NMR (CDCl3, ppm): 1.26 (3H, dd), 1.94 (3H, s), 2.31
(3H, s), 2.61-2.52 (2H, m), 4.33-4.29 (1H, m), 524 (2H, s), 6.34
(1H, d), 7.21-7.11 (3H, m), 7.39 (1H, d), 7.75 (1H, d), 7.95 (1H,
dd), 8.13 (1H, d,)8.38 (1H, s) 636 1H-NMR (CDCl3, ppm): 1.25 (3H,
dd), 1.93 (2H, s), 2.31 (3H, s), 2.65-2.52 (2H, m), 4.32-4.29 (1H,
m), 5.26 (2H, s), 6.40 (1H, d), 7.21-7.11 (3H, m), 8.39 (1H, s),
7.42 (1H, s), 7.74 (1H, d), 7.94 (1H, d), 8.11 (1H, d) 640 1H-NMR
(CDCl3, ppm): 1.29 (3H, dd), 1.95 (3H, s), 2.32 (3H, s), 2.62-2.54
(2H, m), 4.34-4.27 (1H, m), 5.31 (2H, s), 6.21 (1H, d), 7.96 (1H,
d), 8.19 (1H, t), 7.21-7.13 (3H, m), 7.62 (1H, s), 7.78 (1H, d),
8.37 (1H, d) 651 1H-NMR (CDCl3, ppm): 1.24 (3H, dd), 1.96 (3H, s),
2.31 (3H, s), 2.60-2.55 (2H, m), 4.36-4.31 (1H, m), 5.31 (2H, s),
6.34 (1H, d), 7.16-7.14 (2H, m), 7.43 (1H, t), 7.53 (1H, dd), 7.64
(1H, s), 7.71 (1H, d), 8.12 (1H, d), 8.50 (1H, s) 654 1H-NMR
(CDCl3, ppm): 1.26 (3H, dd), 1.93 (3H, s), 2.34 (3H, d), 2.62-2.55
(2H, m), 4.34-4.29 (1H, m), 5.31 (2H, s), 6.23 (1H, d), 7.24-7.14
(3H, m), 7.63 (1H, s), 7.78 (1H, d), 7.97 (1H, dd), 8.20 (1H, d),
8.37 (1H, s) 658 1H-NMR (CDCl3, ppm): 1.44-1.38 (3H, m), 2.35-2.30
(6H, m), 2.90-2.77 (2H, m), 4.56-4.48 (1H, m), 5.32 (2H, s),
7.18-7.14 (3H, m), 7.44-7.37 (1H, m), 7.56-7.52 (1H, m), 7.67-7.64
(2H, m), 8.10-8.07 (1H, m), 8.44-8.39 (1H, m) 660 1H-NMR (CDCl3,
ppm): 1.25 (4H, dd), 1.90 (3H, s), 2.31 (3H, s), 2.63-2.55 (2H, m),
4.37-4.28 (1H, m), 5.34 (2H, s), 6.12 (1H, d), 7.22-7.15 (2H, m),
7.63 (1H, d), 7.83 (1H, t), 7.98 (1H, dt), 8.25 (1H, t), 8.34 (1H,
s) 675 1H-NMR (CDCl3, ppm): 1.23 (3H, d), 1.97 (3H, s), 2.33 (3H,
s), 2.63-2.54 (2H, m), 4.38-4.29 (1H, m), 5.41 (2H, s), 6.21 (1H,
d), 7.09 (2H, d), 7.44 (1H, t), 7.54 (1H, d), 7.73 (1H, d), 7.84
(1H, s), 8.07 (1H, d), 8.38 (1H, s) 681 1H-NMR (CDCl3, ppm): 1.25
(3H, d), 1.95 (3H, s), 2.32 (3H, s), 2.62-2.54 (2H, m), 4.36-4.32
(1H, m), 5.52 (2H, s), 6.13 (1H, d), 7.18-7.16 (2H, m), 7.57-7.47
(2H, m), 7.76 (1H, d), 8.17 (1H, d), 8.41 (1H, s) 714 1H-NMR
(CDCl3, ppm): 1.24 (3H, d), 1.99 (3H, s), 2.30 (3H, s), 2.64-2.52
(2H, m), 4.38-4.29 (1H, m), 5.49 (2H, s), 6.15 (1H, d), 7.17-7.15
(2H, m), 7.57-7.43 (2H, m), 7.75 (1H, d), 8.17 (1H, d), 8.41 (1H,
s) 726 1H-NMR (CDCl3, ppm): 1.45-1.37 (3H, m), 2.32-2.30 (6H, m),
2.87-2.83 (2H, m), 4.61-4.46 (1H, m), 5.44 (2H, s), 6.90-6.88 (1H,
m), 7.12-7.09 (2H, m), 7.45-7.42 (1H, m), 7.55-7.52 (1H, m),
7.68-7.66 (1H, m), 7.79-7.77 (1H, m), 8.06-8.04 (1H, m), 8.32-8.24
(1H, m) 727 1H-NMR (CDCl3, ppm): 1.44 (3H, d), 2.30 (3H, s), 2.75
(3H, s), 3.24-3.21 (2H, m), 4.62-4.53 (1H, m), 5.44 (2H, s),
6.87-6.85 (1H, m), 7.08-7.06 (2H, m), 7.42-7.32 (1H, m), 7.50-7.47
(1H, m),
7.60-7.57 (1H, m), 7.77 (1H, s), 7.91-7.87 (1H, m), 8.17-8.14 (1H,
m) 729 1H-NMR (CDCl3, ppm): 1.45 (3H, d), 2.29 (3H, s), 2.75 (3H,
s), 3.34-3.12 (2H, m), 4.59-4.54 (1H, m), 5.38 (2H, s), 6.86 (1H,
d), 7.09-7.06 (2H, m), 7.43-7.33 (1H, m), 7.52-7.46 (1H, m), 7.59
(1H, d), 7.84 (1H, s), 7.90 (1H, d), 8.15 (1H, s) 730 1H-NMR
(CDCl3, ppm): 1.23 (3H, d), 1.96 (3H, s), 2.29 (3H, s), 2.5-2.7
(2H, m), 4.31 (1H, m), 5.34 (2H, s), 6.31 (1H, d), 6.4-7.2 (5H, s),
7.4-7.8 (3H, m), 8.06 (1H, d), 8.41 (1H, bs) 741 1H-NMR (CDCl3,
ppm): 1.26 (3H, d), 1.95 (3H, s), 2.18 (3H, s), 2.30 (3H, s),
2.66-2.48 (2H, m), 4.39-4.20 (1H, m), 5.31 (2H, s), 6.25 (1H, d),
7.07-7.01 (2H, m), 7.44-7.41 (2H, m), 7.55-7.51 (2H, m), 7.71 (1H,
d), 8.01 (1H, d), 8.32 (1H, s) 778 1H-NMR (CDCl3, ppm): 1.31 (3H,
d), 1.95 (3H, s), 2.33 (3H, t), 2.61-2.56 (2H, m), 4.40-4.29 (1H,
m), 5.28 (2H, s), 6.50-6.11 (2H, m), 7.15-7.12 (2H, m), 7.45-7.42
(1H, m), 7.55-7.52 (1H, m), 7.64 (1H, s), 7.72 (1H, d), 8.12 (1H,
d), 8.50 (1H, s) 799 1H-NMR (CDCl3, ppm): 1.23 (3H, d), 1.93 (3H,
s), 2.32 (3H, s), 2.56 (2H, m), 4.22 (1H, m), 5.52 (2H, s),
6.55-6.02 (3H, m), 7.21 (2H, m), 7.57-7.43 (2H, m), 7.76 (1H, d),
8.15 (1H, d), 8.39 (1H, s) 1H-NMR (CDCl3, ppm): 1.24 (3H, d), 1.94
(3H, s), 2.28 (3H, s), 2.52 (1H, dd), 2.62 (1H, dd), 4.30 (1H, m),
5.38 (2H, s), 6.4-7.2 (7H, m), 7.72 (1H, d), 7.93 (1H, d), 8.06
(1H, d), 8.41 (1H, bs) 1H-NMR (CDCl3, ppm): 1.40 (6H, s), 1.93 (3H,
s), 2.77 (2H, s), 5.40 (2H, s), 5.93 (1H, bs), 6.87-7.23 (4H, m),
7.63-7.95 (2H, m), 8.35-8.65 (2H, m)
Synthesis Example 6
Starting material
##STR00031##
[0519] 3-Methyl-4-nitrobenzyl chloride (1.81 g),
3,5-bis(trifluoromethyl)-1H-pyrazole (2.0 g) and potassium
carbonate (1.63 g) were stirred in DMF (20 ml) at 60.degree. C. for
1 hour. After finishing the reaction, water (100 ml) was added
thereto and the mixture was extracted with ethyl acetate. The
organic layer was washed with saturated aqueous solution of sodium
chloride (100 ml) and dried with anhydrous sodium sulfate. After
distilling off the solvent, the obtained residue was purified by
silica gel column chromatography to obtain
1-(3-methyl-4-nitrobenzyl)-3,5-bis-(trifluoromethyl)-1H-pyrazole
(3.3 g).
[0520] .sup.1H-NMR (CDCl.sub.3, ppm): 2.59 (3H, s), 5.50 (2H, s),
6.90 (1H, s), 7.1-7.2 (2H, m), 8.00 (1H, d).
Synthesis Example 7
Starting Material
##STR00032##
[0522] To a mixture of
1-(3-methyl-4-nitrobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole
(1.4 g), ammonium acetate (30.5 g), acetone (60 ml) and water (30
ml), 20% aqueous solution of titanium trichloride (27.5 g) was
added at room temperature and the mixture was stirred at room
temperature for 12 hours. After finishing the reaction, the mixture
was extracted with ethyl acetate, washed with saturated aqueous
solution of sodium chloride and dried with anhydrous sodium
sulfate. After distilling off the solvent, the obtained residue was
purified by silica gel column chromatography to obtain
1-(3-methyl-aminobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (1.19
g).
[0523] .sup.1H-NMR (CDCl.sub.3, ppm): 2.14 (3H, s), 3.66 (2H, m),
5.32 (2H, s), 6.62 (1H, d), 6.89 (1H, s), 6.8-7.1 (2H, m).
Synthesis Example 8
Starting material
##STR00033##
[0525]
1-(3-Methyl-4-nitrobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole
(17.66 g) and iron powder (13.69 g) were heated and stirred in
acetic acid (150 ml) at 40.degree. C. for 5 hours. After finishing
the reaction, an insoluble matter was filtered with Celite and the
filtrate was concentrated under the reduced pressure. To the
residue, 1N aqueous solution of sodium hydrate (200 ml) and ethyl
acetate (200 ml) were added. The organic layer was separated,
washed with water, and then, dried with anhydrous magnesium
sulfate. After distilling off the solvent,
1-(3-methyl-4-aminobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole
(13.0 g), which was the same as that obtained in Synthesis Example
7, was obtained.
Synthesis Example 9
Starting Material
##STR00034##
[0527] 3-Fluorophthalic anhydride (4.98 g) and
1-(3-methyl-4-aminobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole
(9.70 g) were refluxed in acetic acid (43 ml) for 3 hours. After
finishing the reaction, the acetic acid was distilled off wader the
reduced pressure and the obtained crude crystals were washed with
t-butyl methyl ether to obtain the aimed
2-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylphenyl}-4-f-
luoroisoindol-1,3-dione (10.80 g). mp. 158-159.degree. C.
Synthesis Example 10
Starting Material
##STR00035##
[0529] 3-Methyl-4-nitrobenzyl chloride (0.56 g),
5-(difluoromethyl)-1,2-dihydro-2-methyl-3H-1,2,4-(triazol)-3-one
(0.45 g) and potassium carbonate (0.61 g) were stirred in DMF (10
ml) at 50.degree. C. for 5 hours. After finishing the reaction, the
reaction mixture was poured into ice water and extracted with ethyl
acetate. The organic layer was washed with saturated aqueous
solution of sodium chloride and then dried with anhydrous magnesium
sulfate, and the solvent was distilled off under the reduced
pressure. The obtained residue was purified by silica gel column
chromatography to obtain the aimed
5-difluoromethyl-2-methyl-4-(3-methyl-4-nitrobenzyl)-2,4-dihydro-[1,2,4]t-
riazol-3-one (0.45 g).
[0530] .sup.1H-NMR (CDCl.sub.3, ppm): 2.5 (3H, s), 3.5 (3H, s), 4.9
(2H, s), 6.4 (1H, t), 72-7.3 (2H, m), 7.8-7.9 (1H, m).
Synthesis Example 11
Starting Material
##STR00036##
[0532] 3-Methyl-nitrobenzyl chloride (0.43 g),
3-heptafluoropropylsulfanyl-5-trifluoromethyl-1H-(1,2,4)-triazole
(0.70 g), tetrabutylammonium iodide (0.09 g), 18-crown-6 (0.06 g)
and potassium carbonate (0.48 g) were refluxed in acetonitrile (10
ml) for 2 hours. After cooling, the reaction solution was diluted
with ethyl acetate and washed with water and saturated aqueous
solution of sodium chloride. After drying the organic layer with
magnesium sulfate, the solvent was distilled off under the reduced
pressure and the obtained residue was purified by silica gel column
chromatography to obtain 3-hepta
fluoropropylsulfanyl-1-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1H-(1,2-
,4)-triazole (0.30 g).
[0533] .sup.1H-NMR (CDCl.sub.3, ppm): 2.64 (3H, s), 5.62 (2H, s),
7.31-7.25 (2H, m), 8.05-7.86 (1H, m)
Synthesis Example 12
Starting Material
##STR00037##
[0535] To a mixture of
3-heptafluoropropylsulfanyl-1-(3-methyl-4-nitrophenyl)-5-trifluoromethyl--
1H-(1,2,4)-triazole (0.3 g), ammonium acetate (4.8 g), acetone (20
ml) and water (10 ml), 20% aqueous solution of titanium trichloride
(4.3 g) was added at room temperature and the mixture was stirred
at room temperature for 12 hours. After finishing the reaction, the
mixture was extracted with ethyl acetate, washed with saturated
aqueous solution of sodium chloride and dried with anhydrous sodium
sulfate. After distilling off the solvent, the obtained residue was
purified by silica gel column chromatography to obtain
4-(3-heptafluoropropylsulfanyl-5-trifluoromethyl-[1,2,4]triazol-1-ylmethy-
l)-2-methyl-phenylamine (0.28 g)
[0536] .sup.1H-NMR (CDCl.sub.3, ppm): 2.17 (3H, s), 4.16 (1H, brs),
5.40 (2H, s), 6.63-6.59 (2H, m), 7.13-6.99 (1H, m).
Synthesis Example 13
Starting Material
##STR00038##
[0538] An acetonitrile solution (30 ml) of
3-trifluoromethyl-1H-pyrazole (5.0 g), dicerium ammonium nitrate
(10.0 g) and iodine (5.6 g) was refluxed for 1 hour. After cooling,
the reaction solution was washed with saturated aqueous solution of
sodium thiosulfate and saturated aqueous solution of sodium
chloride. After drying the organic layer with magnesium sulfate,
the solvent was distilled off under the reduced pressure to obtain
4-iodo-3-trifluoromethyl-1H-pyrazole (93 g).
[0539] .sup.1H-NMR (CDCl.sub.3, ppm): 7.77 (1H, s).
Synthesis Example 14
Starting Material
##STR00039##
[0541] 3-Methyl-4-nitrobenzyl chloride (0.77 g),
4-iodo-3-trifluoromethyl-1H-pyrazole (0.99 g) and potassium
carbonate (0.63 g) were stirred in DMF (10 ml) at 60.degree. C. for
1 hour. After cooling, the reaction solution was diluted with ethyl
acetate and washed with water and saturated aqueous solution of
sodium chloride. After drying the organic layer with magnesium
sulfate, the solvent was distilled off under the reduced pressure
and the obtained residue was purified by silica gel column
chromatography to obtain
4-iodo-1-(3-methyl-4-nitrobenzyl)-3-trifluoromethyl-1H-pyrazole
(1.0 g).
[0542] .sup.1H-NMR (CDCl.sub.3, ppm): 2.62 (3H, s), 5.36 (2H, s),
7.21-7.18 (2H, m), 7.52 (1H, s), 7.98 (1H, d).
Synthesis Example 15
Starting Material
##STR00040##
[0544]
4-Iodo-1-(3-methyl-4-nitrobenzyl)-3-trifluoromethyl-1H-pyrazole
(2.06 g), copper powder (0.95 g), iodopentafluoroethane (4.92 g)
and DMF (13 ml) were set in an autoclave and heated and stirred for
8 hours, maintaining the inside temperature of 130-135.degree. C.
After cooling to room temperature, the reaction mixture was diluted
with ethyl acetate (50 ml) and an insoluble matter was filtered
with Celite and washed with ethyl acetate. The filtrate was
concentrated under the reduced pressure and the obtained residue
was purified by silica gel column chromatography to obtain
1-(3-methyl-4-nitrobenzyl)-4-pentafluoroethyl-3-trifluoromethyl-
-1H-pyrazole (1.39 g)
[0545] .sup.1H-NMR (CDCl.sub.3, ppm): 2.63 (3H, s), 5.38 (2H, s),
7.21-7.27 (2H, m), 7.74 (1H, s), 8.00 (1H, d).
Synthesis Example 16
Starting Material
##STR00041##
[0547] 3-Methyl-4-nitrobenzyl chloride (8.57 g),
4-iodo-3-pentafluoroethyl-1H-pyrazole (16.00 g) and potassium
carbonate (7.66 g) were stirred in DMF (70 ml) at 70.degree. C. for
1 hour. After cooling, the reaction solution was poured into water
and extracted with ethyl acetate. The organic phase was washed with
water and saturated aqueous solution of sodium chloride. After
drying the organic layer with sodium sulfate, the solvent was
distilled off under the reduced pressure and the obtained residue
was purified by silica gel column chromatography to obtain
4-iodo-1-(3-methyl-4-nitrobenzyl)-3-pentafluoroethyl-1H-pyrazol- e
(4.60 g).
[0548] .sup.1H-NMR (CDCl.sub.3, ppm): 2.60 (3H, s), 5.38 (2H, s),
7.22-7.15 (2H, m), 7.53 (1H, s), 7.98 (1H, d).
Synthesis Example 17
Starting Material
##STR00042##
[0550]
4-Iodo-1-(3-methyl-4-nitrobenzyl)-3-pentafluoroethyl-1H-pyrazole
(1.84 g), (trifluoromethyl)trimethylsilane (1.14 g), copper(I)
iodide (1.52 g), potassium fluoride (0.28 g) were stirred in DMF (8
ml) at 100.degree. C. for 8 hours. After cooling, the mixture was
poured into water and extracted with ethyl acetate. The combined
organic phase was washed with saturated aqueous solution of sodium
chloride. After drying the organic layer with sodium sulfate, the
solvent was distilled off under the reduced pressure and the
obtained residue was purified by silica gel column chromatography
to obtain
1-(3-methyl-4-nitro-benzyl)-3-pentafluoroethyl-4-trifluoromethyl-1H-pyraz-
ole (0.32 g).
[0551] .sup.1H-NMR (CDCl.sub.3, ppm): 2.61 (3H, s), 5.41 (2H, s),
7.31-7.18 (2H, m), 7.78 (1H, s), 8.00 (1H, d).
Synthesis Example 18
Starting Material
##STR00043##
[0553]
4-Iodo-1-(3-methyl-4-nitrobenzyl)-3-trifluoromethyl-1H-pyrazole
(2.06 g), copper powder (0.95 g), heptafluoro-1-iodopropane (2.96
g) and DMF (14 ml) were set in an autoclave and heated and stirred
for 8 hours, maintaining the inside temperature of 130-135.degree.
C. After cooling to room temperature, the reaction mixture was
diluted with ethyl acetate (50 ml) and an insoluble matter was
filtered with Celite and washed with ethyl acetate. The filtrate
was concentrated under the reduced pressure and the obtained
residue was purified by silica gel column chromatography to obtain
1-(3-methyl-4-nitrobenzyl)-4-pentafluoropropyl-3-trifluoromethy-
l-1H-pyrazole (0.80 g).
[0554] .sup.1H-NMR (CDCl.sub.3, ppm): 2.62 (3H, s), 5.42 (2H, s),
7.19-7.20 (2H, m), 7.74 (1H, s), 8.02 (1H, d).
Synthesis Example 19
Starting Material
##STR00044##
[0556]
4-Iodo-1-(3-methyl-4-nitrobenzyl)-3-trifluoromethyl-1H-pyrazole
(2.47 g), copper powder (1.14 g), nonafluoro-1-iodobutane (4.15 g)
and DMF (16 ml) were set in an autoclave and heated and stirred for
8 hours, maintaining the inside temperature of 130-135.degree. C.
After cooling to room temperature, the reaction mixture was diluted
with toluene (50 ml) and an insoluble matter was filtered with
Celite and washed with toluene. The filtrate was concentrated under
the reduced pressure and the obtained residue was purified by
silica gel column chromatography to obtain
1-(3-methyl-4-nitrobenzyl)-4-nonafluorobutyl-3-trifluoromethyl-1H-pyrazol-
e (1.50 g).
[0557] .sup.1H-NMR (CDCl.sub.3, ppm): 2.62 (3H, s), 5.42 (2H, s),
7.18-7.24 (2H, m), 7.74 (1H, s), 8.00 (1H, d).
Synthesis Example 20
Starting Material
##STR00045##
[0559] An acetonitrile solution (20 ml) of
3-trifluoromethyl-1H-pyrazole (1.0 g), dicerium ammonium nitrate
(2.0 g) and bromine (0.7 g) was refluxed for 2 hours. After
cooling, the reaction solution was washed with saturated aqueous
solution of sodium thiosulfate and saturated aqueous solution of
sodium chloride. After drying the organic layer with magnesium
sulfate, the solvent was distilled off under the reduced pressure
to obtain 4-bromo-3-trifluoromethyl-1H-pyrazole (1.6 g).
[0560] .sup.1H-NMR (CDCl.sub.3, ppm): 7.73 (1H, s), 12.86 (1H,
brs).
Synthesis Example 21
Starting Material
##STR00046##
[0562] 3-Methyl-4-nitrobenzyl chloride (0.77 g),
4-bromo-3-trifluoromethyl-1H-pyrazole (0.90 g) and potassium
carbonate (0.57 g) were stirred in DMF (10 ml) at room temperature
for 2 hours. The reaction solution was diluted with ethyl acetate
and washed with water and saturated aqueous solution of sodium
chloride. After drying the organic layer with magnesium sulfate,
the solvent was distilled off under the reduced pressure and the
obtained residue was purified by silica gel column chromatography
to obtain
1-(3-methyl-4-nitrobenzyl)-4-bromo-3-trifluoromethyl-1H-pyrazole
(0.9 g).
[0563] .sup.1H-NMR (CDCl.sub.3, ppm): 2.58 (3H, s), 5.35 (2H, s),
7.24-7.21 (2H, m), 7.49 (1H, s), 7.98 (1H, d).
Synthesis Example 22
Starting Material
##STR00047##
[0565] An acetonitrile solution (20 ml) of
3-trifluoromethyl-1H-pyrazole (0.5 g), dicerium ammonium nitrate
(1.0 g) and N-chlorosuccinimide (0.7 g) was refluxed for 3 hours.
After cooling, the reaction solution was washed with saturated
aqueous solution of sodium thiosulfate and saturated aqueous
solution of sodium chloride. After drying an organic layer with
magnesium sulfate, the solvent was distilled off under the reduced
pressure to obtain 4-chloro-3-trifluoromethyl-1H-pyrazole (0.9
g).
[0566] .sup.1H-NMR (CDCl.sub.3, ppm): 7.80 (1H, s).
Synthesis Example 23
Starting Material
##STR00048##
[0568] 3-Methyl-4-nitrobenzyl chloride (0.82 g),
4-chloro-3-trifluoromethyl-1H-pyrazole (0.63 g) and potassium
carbonate (0.61 g) were stirred in DMF (10 ml) at room temperature
for 2 hours. The reaction solution was diluted with ethyl acetate
and washed with water and saturated aqueous solution of sodium
chloride. After drying the organic layer with magnesium sulfate,
the solvent was distilled off under the reduced pressure and the
obtained residue was purified by silica gel column chromatography
to obtain
1-(3-methyl-4-nitrobenzyl)-4-chloro-3-trifluoromethyl-1H-pyrazole
(0.98 g).
[0569] .sup.1H-NMR (CDCl.sub.3, ppm): 2.62 (3H, s), 5.33 (2H, s),
7.21-7.19 (2H, m), 7.46 (1H, s), 7.98 (1H, d).
Synthesis Example 24
Starting Material
##STR00049##
[0571] 2-(Trifluoroacetyl)-1H-pyrrole (0.97 g) was added to DMF
solution (10 ml) of 60% sodium hydride (0.16 g) and the mixture was
stirred at room temperature for 30 mutes. 3-Methyl-4-nitrobenzyl
chloride (1.0 g) was added thereto and the mixture was stirred at
room temperature for 2 hours. The reaction solution was diluted
with ethyl acetate and washed with water and saturated aqueous
solution of sodium chloride. After drying the organic layer with
magnesium sulfate, the solvent was distilled off under the reduced
pressure and the obtained residue was purified by silica gel column
chromatography to obtain
1-(3-methyl-4-nitrobenzyl)-2-(trifluoroacetyl)-1H pyrrole (1.53
g).
[0572] .sup.1H-NMR (CDCl.sub.3, ppm): 2.55 (3H, s), 5.59 (2H, s),
6.44-6.41 (1H, m), 6.99 (1H, d), 7.04 (1H, s), 7.22-7.19 (1H, m),
7.35-7.32 (1H, m), 7.93 (1H, d).
Synthesis Example 25
Starting Material
##STR00050##
[0574] An acetonitrile solution (20 ml) of 2-(trifluoroacetyl)-1H
pyrrole (0.5 g), dicerium ammonium nitrate (0.84 g) and iodine
(0.47 g) was refluxed for 2 hours. After cooling, the reaction
solution was washed with saturated aqueous solution of sodium
thiosulfate and saturated aqueous solution of sodium chloride.
After drying the organic layer with magnesium sulfate, the solvent
was distilled off under the reduced pressure to obtain
4-iodo-2-(trifluoroacetyl)-1H pyrrole (0.6 g).
[0575] .sup.1H-NMR (CDCl.sub.3, ppm): 7.28-7.35 (2H, m), 9.52 (1H,
brs).
Synthesis Example 26
Starting Material
##STR00051##
[0577] 3-Methyl-4-nitrobenzyl chloride (0.63 g),
4-iodo-2-(trifluoroacetyl)pyrrole (0.89 g) and potassium carbonate
(0.57 g) were stirred in DMF (10 ml) at room temperature for 2
hours. The reaction solution was diluted with ethyl acetate and
washed with water and saturated aqueous solution of sodium
chloride. After drying the organic layer with magnesium sulfate,
the solvent was distilled off under the reduced pressure and the
obtained residue was purified by silica gel column chromatography
to obtain
4-iodo-1-(3-methyl-4-nitrobenzyl)-2-trifluoroacetyl-1H-pyrrole
(0.45 g).
[0578] .sup.1H-NMR (CDCl.sub.3, ppm): 2.60 (3H, s), 5.56 (2H, s),
7.05-7.12 (2H, m), 7.21 (1H, d), 7.39 (1H, s), 7.94 (1H, d).
Synthesis Example 27
Starting Material
##STR00052##
[0580]
4-Iodo-1-(3-methyl-4-nitrobenzyl)-2-trifluoroacetyl-1H-pyrrole
(1.75 g), copper powder (5.08 g), iodopentafluoroethane (5.92 g)
and DMSO (6 ml) were set in an autoclave and heated and stirred for
8 hours, maintaining the inside temperature of 120.degree. C. After
finishing the reaction, the reaction mixture was poured into ice
water and an insoluble matter was filtered with Celite, and then,
it was extracted with ethyl acetate. The extracted solution was
washed with water and then dried with anhydrous sodium sulfate.
After distilling off the solvent, the obtained residue was purified
by silica gel column chromatography to obtain
1-(3-methyl-4-nitrophenyl)-4-pentafluoroethyl-1H-pyrrole (1.35
g).
[0581] .sup.1H-NMR (CDCl.sub.3, ppm): 2.59 (3H, s), 5.62 (2H, s),
7.00-7.10 (2H, m), 7.43-7.50 (2H, m), 7.96 (1H, d).
[0582] Some specific examples of other processes to synthesize the
compounds of the aforementioned formula (IX) are shown below.
Synthesis Example 28
Starting Material
##STR00053##
[0584] To a toluene suspension of ethyl 4,4,4-trifluoroacetoacetate
(5.0 g), sodium hydride (1.1 g) was slowly added and the mixture
was stirred for 1 hour. After adding
4-chloromethyl-2-methyl-1-nitro-benzene (5.5 g) and potassium
iodide dissolved in acetone (0.5 g), the reaction solution was
refluxed for 5 hours. After cooling, the solvent was distilled off
under reduced pressure. The residue was suspended in ethyl acetate
and washed with 1N aqueous solution of hydrochloric acid. After
drying the organic layer with sodium sulfate, the solvent was
distilled off and the obtained residue was purified by silica gel
column chromatography to obtain ethyl
4,4,4-trifluoro-2-(3-methyl-4-nitro-benzyl)-3-oxo-butyrate (6.3 g).
n.sub.D.sup.20 1.4970
Synthesis Example 29
Starting Material
##STR00054##
[0586] Ethyl 4,4,4-trifluoro-2-(3-methyl-4-nitro
benzyl)-3-oxo-butyrate (2.0 g), hydrazine monohydrate (0.5 g) and a
small amount of p-toluenesulfonic acid were dissolved in toluene,
and the mixture was refluxed for 4 hours. After cooling, the
solvent was distilled off under reduced pressure. The residue was
suspended in ethyl acetate and washed with 1N aqueous solution of
hydrochloric acid. After drying the organic layer with sodium
sulfate, the solvent was distilled off and the obtained residue was
purified by silica gel column chromatography to obtain
4-(3-methyl-4-nitro-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one
(1.0 g).
[0587] .sup.1H-NMR (DMSO-d.sub.6, 90 MHz): .delta.2.2 (3H, s), 3.8
(2H, s), 7.0 (1H, d, J=5.5 Hz), 7.2 (1H, s), 7.8 (1H, d, J=5.5 Hz),
11.2 (1H, brs).
Synthesis Example 30
Starting Material
##STR00055##
[0589] To a DMF suspension of
4-(3-methyl-4-nitro-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one
(1.0 g) and potassium carbonate (1.5 g), chlorodifluoromethane (5.7
g) was sealed in by using a balloon. After 5 hours, after the gas
in the solution was saturated, the vessel was tightly closed and
the mixture was stirred at 50.degree. C. for 5 hours. After
cooling, the solvent was distilled off and the obtained residue was
dissolved in ethyl acetate and washed with water and saturated
aqueous solution of sodium chloride. After drying the organic layer
with sodium sulfate, the solvent was distilled off and the obtained
residue was purified by silica gel column chromatography to obtain
5-difluoromethoxy-1-difluoromethyl-4-(3-methyl-4-nitro-benzyl)-3-trifluor-
omethyl-1H-pyrazole (IX-1) (0.5 g) and
3-difluoromethoxy-1-difluoromethyl-4-(3-methyl-4-nitro-benzyl)-5-trifluor-
omethyl-1H-pyrazole (IX-2) (0.4 g) respectively.
[0590] (IX-1): n.sub.D.sup.20 1.4780, (IX-2): n.sub.D.sup.20
1.4855.
Synthesis Example 31
Starting Material
##STR00056##
[0592] (3-Methyl-4-nitrophenyl)-hydrazine (3.0 g) and
hexafluoroacetylacetone (3.7 g) were dissolved in toluene and the
solution was refluxed for 6 hours. After cooling, the solvent was
distilled off and the obtained residue was purified by silica gel
column chromatography to obtain
1-(3-methyl-4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole
(5.6 g). n.sub.D.sup.20 1.4890.
Synthesis Example 32
Starting Material
##STR00057##
[0594] (3-Methyl-4-nitro-phenyl)-hydrazine (2.0 g) and
1,1,1,5,5,6,6,6-octafluoro-2,4-hexanedione (3.1 g) were dissolved
in toluene and the solution was refluxed for 6 hours. After
cooling, the solvent was distilled off and the obtained residue was
purified by silica gel column chromatography to obtain
1-(3-methyl-4-nitro-phenyl)-3-pentafluoroethyl-5-trifluoromethyl-1H-pyraz-
ole (IX-3) (3.0 g) and
2-(3-methyl-nitro-phenyl)-5-pentafluoroethyl-3-trifluoromethyl-3,4-dihydr-
o-2H-pyrazol-3-ol (IX-4) (0.5 g), respectively.
[0595] (IX-3): n.sub.D.sup.20 1.4690,
[0596] (IX-4): .sup.1H-NMR (CDCl.sub.3, 90 MHz): .delta.2.6 (3H,
s), 3.3 (1H, br d, J=16 Hz), 3.7 (1H, br d, J=16 Hz), 4.1 (1H, s),
7.2 (2H, m), 7.8 (1H, d, J=7.8 Hz).
Synthesis Example 33
Starting Material
##STR00058##
[0598] To a THF suspension of 1-(3-methyl-4-nitro-phenyl)-ethanone
(2.0 g), sodium hydride (0.6 g) was slowly added and the mixture
was stirred for 1 hour. After adding ethyl trifluoroacetate (1.6
g), the reaction mixture was refluxed for 5 hours. After cooling,
the solvent was distilled off under reduced pressure. The residue
was suspended in ethyl acetate and washed with 1N aqueous solution
of hydrochloric acid. After drying the organic layer with sodium
sulfate, the solvent was distilled off and the obtained residue was
purified by silica gel column chromatography to obtain
4,4,4-trifluoro-1-(3-methyl-4-nitro-phenyl)-butane-1,3-dione (2.5
g).
[0599] .sup.1H NMR (CDCl.sub.3, 90 MHz): .delta.2.6 (3H, s), 6.5
(1H, s), 7.7-8.1 (3H, m).
Synthesis Example 34
Starting Material
##STR00059##
[0601] A toluene solution of
4,4,4-trifluoro-1-(3-methyl-4-nitro-phenyl)-butane-1,3-dione (1.8
g), 2,2,2-trifluoroethylhydrazine (1.2 g) and a catalytic amount of
p-toluenesulfonic acid were refluxed for 6 hours. After cooling,
the solvent was distilled off and the obtained residue was purified
by silica gel column chromatography to obtain
3-(3-methyl-4-nitro-phenyl)-1-(2,2,2-trifluoro-ethyl)-5-trifluoro-methyl--
1H-pyrazole (IX-5) (1.1 g) and 5-(3-methyl-4-nitro
phenyl)-1-(2,2,2-trifluoro-ethyl)-3-trifluoromethyl-1H-pyrazole
(IX-6) (0.5 g), respectively.
[0602] (IX-5) mp; 98-104.degree. C., (IX-6) mp; 50-53.degree.
C.
Synthesis Example 35
Starting Material
##STR00060##
[0604] To a dichloromethane solution of
2,2-dimethyl-1,3-dioxane-4,6-dione (10 g) and dimethylaminopyridine
(17 g), a dichloromethane solution of 3-methyl-4-nitro-benzoyl
chloride (14 g) was added dropwise under ice cooling. After
stirring at room temperature for 3 hours and then adding 100 ml of
ethanol, the mixture was refluxed for 2 hours. After cooling, the
solvent was distilled off under the reduced pressure. The residue
was dissolved in ethyl acetate and washed with 1N aqueous solution
of hydrochloric acid. After drying the organic layer with sodium
sulfate, the solvent was distilled off and the obtained residue was
purified by silica gel column chromatography to obtain ethyl
3-(3-methyl-4-nitro-phenyl)-3-oxo-propionate (12.4 g). mp;
207-211.degree. C.
Synthesis Example 36
Starting Material
##STR00061##
[0606] To an ethanol solution of ethyl
3-(3-methyl-4-nitro-phenyl)-3-oxo propionate (3.0 g), hydrazine
monohydrate (0.9 g) and a small amount of p-toluenesulfonic acid
were added and the mixture was refluxed for 5 hours. After cooling,
the solvent was distilled off under the reduced pressure and the
obtained residue was purified by silica gel column chromatography
to obtain 5-(3-methyl-4-nitro-phenyl)-2,4-dihydro-pyrazol-3-one
(2.6 g). mp; 218-219.degree. C.
Synthesis Example 37
Starting Material
##STR00062##
[0608] To a DMF suspension of
5-(3-methyl-4-nitro-phenyl)-2,4-dihydro-1H-pyrazol-3-one (2.0 g)
and potassium carbonate (6.3 g), chlorodifluoromethane (8.7 g) was
sealed in by using a balloon. After 5 hours, after the gas in the
solution was saturated, the vessel was tightly closed and the
mixture was stirred at 50.degree. C. for 5 hours. After cooling,
the solvent was distilled off and the obtained residue was
dissolved in ethyl acetate and washed with water and saturated
aqueous solution of sodium chloride. After drying with sodium
sulfate, the solvent was distilled off and the obtained residue was
purified by silica gel column chromatography to obtain
5-difluoromethoxy-1-difluoromethyl-3-(3-methyl-4-nitro-phenyl)-1H-pyrazol-
e (IX-7) (0.7 g) and
3-difluoromethoxy-1-difluoromethyl-5-(3-methyl-4-nitro-phenyl)-1H-pyrazol-
e (IX-8) (0.5 g), respectively.
[0609] (IX-7) rap; 80-82.degree. C., (IX-8) mp; 99-100.degree.
C.
Synthesis Example 38
Starting Material
##STR00063##
[0611] To an ethanol solution (60 ml) of hydrazine monohydrate
(5.00 g), an ethanol solution (20 ml) of 3-methyl-4-nitrobenzyl
chloride (3.71 g) was added dropwise while refluxing it, and the
mixture was continuously refluxed for 6 hours. After finishing the
reaction, the solvent was distilled off and
(3-methyl-4-nitrobenzyl)-hydrazine (3.50 g) was obtained.
[0612] .sup.1H-NMR (CDCl.sub.3, ppm): 2.60 (3H, s), 2.65-3.35 (3H,
m), 3.95 (2H, s), 7.20-7.40 (2H, m), 7.98 (1H, d).
Synthesis Example 39
Starting Material
##STR00064##
[0614] (3-Methyl-4-nitrobenzyl)-hydrazine (1.81 g) and
5-ethoxy-1,1,1,2,2-pentafluoro-4-penten-3-one (2.18 g) were
refluxed in ethanol (60 ml) for 8 hours, and p-toluenesulfonic acid
(0.10 g) was added thereto and the mixture was further refluxed for
6 hours. After finishing the reaction, the solvent was distilled
off and the obtained residue was purified by silica gel column
chromatography (mixed solvent of n-hexane and ethyl acetate) to
obtain 1-(3-methyl-4-nitrobenzyl)-5-pentafluoroethyl-1H-pyrazole
(0.96 g) as the first elution portion and
1-(3-methyl-4-nitrobenzyl)-3-pentafluoroethyl-1H-pyrazole (0.50 g)
as the second elution portion.
[0615] (IX-9): .sup.1H-NMR (CDCl.sub.3, ppm): 2.61 (3H, s), 5.49
(2H, s), 6.70 (1H, bs), 7.05-7.15 (2H, m), 7.66 (1H, bs), 7.94 (1H,
d).
[0616] (IX-10): .sup.1H-NMR (CDCl.sub.3, ppm): 2.64 (3H, s), 5.40
(2H, s), 6.63 (1H, d), 7.07-7.20 (2H, m), 7.52 (1H, d), 7.95 (1H,
d).
Synthesis Example 40
Starting Material
##STR00065##
[0618] A mixture of 5-fluoro-2-nitrotoluene (2.33 g),
4-iodo-1H-pyrazole (2.91 g) and potassium carbonate (2.49 g) was
heated and stirred in DMF (30 ml) at 140.degree. C. for 4 hours.
After cooling to room temperature, the reaction mixture was poured
into ice water to separate out crystals. The obtained crystals were
filtered, washed with water and dried, and
4-iodo-1-(3-methyl-4-nitrophenyl)-1H-pyrazole (4.60 g) was
obtained.
[0619] .sup.1H-NMR (CDCl.sub.3, ppm): 2.70 (3H, s), 7.50-7.70 (3H,
m), 7.95-8.15 (2H, m).
Synthesis Example 41
Starting Material
##STR00066##
[0621] 4-Iodo-1-(3-methyl-4-nitrophenyl)-1H-pyrazole (1.98 g),
copper powder (1.14 g), iodopentafluoroethane (8.85 g) and DMSO (9
ml) were set in an autoclave and heated and stirred for 8 hours,
maintaining the inside temperature of 100.degree. C. After
finishing the reaction, the reaction mixture was poured into ice
water and an insoluble matter was filtered with Celite, and then,
it was extracted with ethyl acetate. The extracted solution was
washed with water and dried with anhydrous sodium sulfate. After
distilling off the solvent, the obtained residue was purified by
silica gel column chromatography to obtain
1-(3-methyl-4-nitrophenyl)-4-pentafluoroethyl-1H-pyrazole (0.72
g).
[0622] .sup.1H-NMR (CDCl.sub.3, ppm): 2.70 (3H, s), 7.60-7.73 (2H,
m), 7.93 (1H, s), 8.13 (1H, d), 8.23 (1H, s).
Synthesis Example 42
Starting Material
##STR00067##
[0624] To a suspension of methanol (300 ml) of
3-methyl-4-nitroacetophenone (26.88 g), sodium borohydride (8.51 g)
was added at 0.degree. C. over a period of 1 hour. The mixture was
further stirred at room temperature for 8 hours. After finishing
the reaction, the reaction mixture was poured into ice water (1,000
ml) and extracted with ether. The organic layer was washed with
saturated aqueous solution of sodium chloride and dried with
anhydrous magnesium sulfate. After distilling off the solvent, the
aimed 1-(3-methyl-4-nitrophenyl)-ethanol (23.33 g) was
obtained.
[0625] .sup.1H-NMR (CDCl.sub.3, ppm): 1.51 (3H, d), 1.98 (1H, d),
2.62 (3H, s), 4.90-5.01 (1H, m), 7.28-7.35 (2H, m), 7.98 (1H,
d).
Synthesis Example 43
Starting Material
##STR00068##
[0627] Into a THF solution (35 ml) of
1-(3-methyl-4-nitrophenyl)-ethanol (5.44 g) and triethylamine (3.95
g), a THF solution (10 ml) of methanesulfonyl chloride (3.48 g) was
added dropwise at 5.degree. C. over a period of 30 minutes.
Further, the mixture was stirred at room temperature for 8 hours.
After finishing the reaction, the solvent was distilled off and the
residue was dissolved in ethyl acetate (100 ml). It was washed with
2N aqueous solution of hydrochloric acid and saturated aqueous
solution of sodium bicarbonate and then dried with anhydrous
magnesium sulfate. After distilling off the solvent, the aimed
1-(3-methyl-4-nitrophenyl)-ethyl methanesulfonate (5.80 g) was
obtained.
[0628] .sup.1H-NMR (CDCl.sub.3, ppm): 1.74 (3H, d), 2.65 (3H, s),
2.95 (3H, s), 5.76 (1H, q), 7.35-7.45 (2H, m), 8.01 (1H, d).
Synthesis Example 44
Starting Material
##STR00069##
[0630] 1-(3-Methyl-4-nitrophenyl)-ethyl methanesulfonate (2.59 g),
3-trifluoromethyl-1H-pyrazole (1.09 g), potassium carbonate (1.66
g) and 18-crown-6 (0.26 g) were refluxed in acetonitrile (100 ml)
for 6 hours. After finishing the reaction, water (100 ml) was added
to the mixture and extracted with ethyl acetate. The organic layer
was washed with saturated aqueous solution of sodium bicarbonate
and then dried with anhydrous sodium sulfate. After distilling off
the solvent, the obtained residue was purified by silica gel column
chromatography to obtain
1-[1-(3-methyl-4-nitrophenyl)-ethyl]-3-trifluoromethyl-1H-pyrazole
(1.60 g).
[0631] .sup.1H-NMR (CDCl.sub.3, ppm): 1.95 (3H, d), 2.59 (3H, s),
5.59 (1H, q), 6.57 (1H, bs), 7.13-7.20 (2H, m), 7.47 (1H, bs), 8.00
(1H, d).
Synthesis Example 45
Starting Material
##STR00070##
[0633] Ethyl pentafluoropropylenate (14.6 g) and hydrazine
monohydrate (3.6 g) were refluxed in tetrahydrofuran (300 ml) for 1
hour. After cooling to room temperature, trifluoroacetamidine (10.0
g) was added dropwise to the mixture and it was refluxed for 3
hours. After finishing the reaction, saturated aqueous solution of
sodium hydrogen carbonate was added thereto and the mixture was
extracted with ethyl acetate. After drying the organic layer with
anhydrous magnesium sulfate, the solvent was distilled off to
obtain crude
3-pentafluoroethyl-5-trifluoromethyl-1H-(1,2,4)-triazole (7.9
g).
Synthesis Example 46
Starting Material
##STR00071##
[0635] 1-(3-Methyl-4-nitrophenyl)-ethyl methanesulfonate (2.5 g),
3-pentafluoroethyl-5-trifluoromethyl-1H-(1,2,4)-triazole (2.2 g),
potassium carbonate (1.6 g) and 18-crown-6 (0.26 g) were refluxed
in acetonitrile (100 mil) for 6 hours. After finishing the
reaction, water (100 ml) was added thereto and the mixture was
extracted with ethyl acetate. The organic layer was washed with
saturated aqueous solution of sodium chloride (100 ml) and then
dried with anhydrous sodium sulfate. After distilling off the
solvent, the obtained residue was purified by silica gel column
chromatography (mixed solvent of n-hexane and ethyl acetate) to
obtain (IX-11) 1-([1-(3-methyl-4-nitro
phenyl)-ethyl]-5-pentafluoroethyl-3-trifluoromethyl-1H-(1,2,4)-triazole
(0.95 g) as the first elution portion and (IX-12)
1-([1-(3-methyl-4-nitro-phenyl)-ethyl]-3-pentafluoroethyl-5-trifluorometh-
yl-1H-(1,2,4)-triazole (1.35 g) as the second elution portion.
[0636] (IX-11)
[0637] .sup.1H-NMR (CDCl.sub.3) .delta.: 8.03-7.97 (1H, m), 7.37
(2H, t, J=5.4 Hz), 5.86 (1H, q, J=7.0 Hz), 2.62 (3H, s), 2.00 (3H,
d, J=7.0 Hz).
[0638] (IX-12)
[0639] .sup.1H-NMR (CDCl.sub.3) .delta.: 7.98 (1H, d; J=8.2 Hz),
7.34 (2H, t, J=7.1 Hz), 5.81 (1H, q, J=7.0 Hz), 2.63 (3H, s), 2.01
(3H, d, J=7.0 Hz).
Synthesis Example 47
Starting Material
##STR00072##
[0641] Sodium hydride (0.10 g) was added to a DMF solution (12 ml)
of 4-methyl-5-pentafluoroethyl-4H-[1,2,4]triazol-3-thiol (0.70 g),
and the mixture was stirred at room temperature until the
generation of hydrogen gas stopped. Continuously,
5-fluoro-2-nitrotoluene (0.47 g) was added thereto and the mixture
was further stirred at room temperature for 1 hour. After cooling
to room temperature, the reaction mixture was poured into ice water
and extracted with ethyl acetate. The organic layer was washed with
saturated aqueous solution of sodium chloride and then dried with
anhydrous sodium sulfate. After distilling off the solvent, the
obtained residue was purified by silica gel column chromatography
(mixed solvent of n-hexane and ethyl acetate) to obtain the aimed
4-methyl-3-(3-methyl-4-nitrophenyl
sulfanyl)-5-pentafluoroethyl-4H-(1,2,4)-triazole (0.55 g).
[0642] .sup.1H-NMR (CDCl.sub.3, ppm): 2.70 (3H, s), 3.80 (3H, s),
8.10-8.30 (3H, m).
Synthesis Example 48
Starting Material
##STR00073##
[0644] A mixture of
2-methylmelcapto-4.6-bistrifluoromethyl-pyrimidine (36 g), oxone
(126 g), water (500 ml) and chloroform (110 ml) was refluxed for 2
days. After cooling to room temperature, the mixture was extracted
with dichloromethane. The obtained organic layer was washed with
water and then dried with anhydrous sodium sulfate. After
distilling off the solvent, the obtained crude crystals were washed
with petroleum ether to obtain
2-methanesulfonyl-4.6-bistrifluoromethyl-pyrimidine (7.5 g).
[0645] .sup.1H-NMR (CDCl.sub.3, ppm): 3.48 (3H, s), 8.19 (1H,
s).
Synthesis Example 49
Starting Material
##STR00074##
[0647] 4-Nitro-m-cresol (0.77 g),
2-methanesulfonyl-4,6-bistrifluoromethyl-pyrimidine (1.77 g) and
potassium carbonate (1.04 g) were refluxed in acetonitrile (15 ml)
for 5 hours. After finishing the reaction, the reaction mixture was
poured into ice to separate out crystals. The obtained crystals
were filtered and dried to obtain
2-(3-methyl-4-nitrophenoxy)-4,6-bistrifluoromethyl-pyrimidine (1.03
g).
[0648] .sup.1H-NMR (CDCl.sub.3, ppm): 2.60 (3H, s), 7.1-7.3 (2H,
m), 7.67 (1H, s), 8.10 (1H, d).
Synthesis Example 50
Starting Material
##STR00075##
[0650] (3-Methyl-4-nitrophenyl)-acetonitrile (3.52 g) was dissolved
in pyridine (30 ml), thereto excess H.sub.2S was bubbled into at
room temperature for 3 hours. Then the mixture was poured onto ice.
The precipitate was collected by suction, washed with water and
dried to obtain 2-(3-methyl-4-nitro-phenyl)-thioacetamide (1.69
g).
[0651] .sup.1H-NMR (CDCl.sub.3, ppm): 2.60 (3H, s), 4.06 (2H, s),
6.40-8.00 (5H, m)
Synthesis Example 51
Starting Material
##STR00076##
[0653] 2-(3-Methyl-4-nitrophenyl)-thioacetamide (1.00 g),
1-bromo-3,3,4,4,4-pentafluoro-2-butanone (1.15 g) and potassium
carbonate (0.79 g) were stirred in DMF (10 ml) at room temperature
for 1 hour. The reaction solution was diluted with ethyl acetate
and washed with water and saturated aqueous solution of sodium
chloride. After drying the organic layer with magnesium sulfate,
the solvent was distilled off under the reduced pressure and the
obtained residue was purified by silica gel column chromatography
to obtain 2-(3-Methyl-4-nitro-phenyl)-thioacetimidic acid
3,3,4,4,4-pentafluoro-2-oxo-butyl ester (1.30 g).
[0654] .sup.1H-NMR (CDCl.sub.3, ppm): 2.55 (3H, s), 3.57 (2H, dd),
3.90 (2H, d), 7.24-7.22 (2H, m), 7.91-7.89 (1H, m)
Synthesis Example 52
Starting Material
##STR00077##
[0656] Trifluoroacetic anhydride (1.47 g) was added to
2-(3-Methyl-4-nitro-phenyl)-thioacetimidic acid
3,3,4,4,4-pentafluoro ester (130 g) and triethylamine (0.71 g) in
dichloromethane (10 ml), and stirred at room temperature for 20
minutes. The reaction solution was washed with water, and the
solvent was distilled off under the reduced pressure and the
obtained residue was purified by silica gel column chromatography
to obtain 2-(3-methyl-4-nitro-benzyl)-4-perfluoroethyl-thiazole
(0.70 g).
[0657] .sup.1H-NMR (CDCl.sub.3, ppm): 2.63 (3H, s), 4.43 (2H, s),
7.30-7.28 (2H, m), 7.75 (1H, s), 7.98 (1H, d)
Synthesis Example 53
Starting Material
##STR00078##
[0659] An acetonitrile solution (20 ml) of
3-pentafluoroethyl-1H-pyrazole (2.0 g), dicerium ammonium nitrate
(3.0 g) and iodine (1.6 g) was refluxed for 3 hours. After cooling,
the reaction solution was washed with saturated aqueous solution of
sodium thiosulfate and saturated aqueous solution of sodium
chloride. After drying the organic layer with magnesium sulfate,
the solvent was distilled off under the reduced pressure to obtain
4-iodo-3-pentafluoroethyl-1H-pyrazole (32 g).
[0660] .sup.1H-NMR (CDCl.sub.3, ppm): 7.77 (1H, s), 11.11 (1H,
m)
Synthesis Example 54
Starting Material
##STR00079##
[0662] 4-Iodo-3-pentafluoroethyl-1H-pyrazole (6.24 g), copper
powder (3.81 g), Iodo-1,1,2,2-tetrafluoroethane (9.12 g) and DMF
(30 ml) were set in an autoclave and heated and stirred for 8
hours, maintaining the inside temperature of 120-125.degree. C.
After cooling to room temperature, the insoluble material was
filtered off through Celite and washed with diethyl ether. The
filtrate was diluted with water and extracted with diethyl ether.
The organic phase was washed with water and dried over sodium
sulfate, and concentrated under the reduced pressure. The crude
product was distilled under reduced pressure to obtain
3-pentafluoroethyl-4-(1,1,2,2-tetrafluoroethyl)-1H-pyrazole (0.60
g), bp. 125-135.degree. C./20 mbar.
[0663] .sup.1H-NMR (CDCl.sub.3, ppm): 5.98 (1H, tt), 7.96 (1H, s),
12.22 (1H, m)
Synthesis Example 55
Starting Material
##STR00080##
[0665] 4-Iodo-3-pentafluoroethyl-1H-pyrazole (12.48 g), copper
powder (7.63 g), iodopentafluoroethane (29.50 g) and DMF (60 ml)
were set in an autoclave and heated and stirred for 8 hours,
maintaining the inside temperature of 120-125.degree. C. After
cooling to room temperature, the insoluble material was filtered
off through Celite and washed with diethyl ether. The filtrate was
diluted with water and extracted with diethyl ether. The organic
phase was washed with water and dried over sodium sulfate, and
concentrated under the reduced pressure. The crude product was
distilled under reduced pressure to obtain
3,4-bis-pentafluoroethyl-1H-pyrazole (1.20 g), bp. 110-115.degree.
C./20 mbar.
[0666] .sup.1H-NMR (CDCl.sub.3, ppm): 7.99 (1H, s), 12.31 (1H,
m).
Synthesis Example 56
Starting Material
##STR00081##
[0668] An acetonitrile solution (20 ml) of 4-methyl-1H-pyrazole
(0.5 g), dicerium ammonium nitrate (1.7 g) and iodine (1.9 g) was
refluxed for 3 hours. After cooling, the reaction solution was
washed with saturated aqueous solution of sodium thiosulfate and
saturated aqueous solution of sodium chloride. After drying the
organic layer with magnesium sulfate, the solvent was distilled off
under the reduced pressure to obtain
3,5-diiodo-4-methyl-1H-pyrazole (1.2 g).
[0669] .sup.1H-NMR (CDCl.sub.3, ppm): 2.03 (3H, s), 6.96 (1H, br
s)
Synthesis Example 57
Starting Material
##STR00082##
[0671] 5-Trifluoromethyl-1H-(1,2,4)-triazole-3-thiol (1.0 g),
heptafluoro-1-iodopropane (3.5 g) and triethylamine (0.90 g) were
stirred in DMF (10 ml) at 90.degree. C. for 24 hours. After cooling
to room temperature; the reaction mixture was diluted with ethyl
acetate and washed with water and saturated aqueous solution of
sodium chloride. After drying the organic layer with magnesium
sulfate, the solvent was distilled off under the reduced pressure
to obtain
3-heptafluoropropylsulfanyl-5-trifluoromethyl-1H-(1,2,4)-triazole
(0.70 g).
USE EXAMPLES
Biological Test Example 1
Test Against Larva of Spodoptera litura
Preparation of Test Solution:
TABLE-US-00003 [0672] Solvent: Dimethylformamide: 3 parts by weight
Emulsifier: Polyoxyethylene alkyl phenyl ether: 1 part by
weight
[0673] In order to make an appropriate formulation of an active
compound, 1 part by weight of the active compound was mixed with
the above-mentioned amount of solvent containing the
above-mentioned amount of emulsifier and the mixture was diluted
with water to a prescribed concentration.
Test Method:
[0674] Leaves of sweet potato were soaked in the test solution
diluted to a prescribed concentration with water, dried in the air
and put in a dish of 9 cm diameter.
[0675] 10 larvae of Spodoptera litura at the third instar were
placed on the leaves and kept in a room at the constant temperature
of 25.degree. C. After 2 and 4 days further leaves of sweet potato
were added and after 7 days the number of dead larvae was counted
and the rate of death was calculated.
[0676] In this test the results of 2 dishes at 1 section were
averaged.
Biological Test Example 2
Test Against Larva of Cnaphalocrocis medinalis Guenee
Test Method:
[0677] Paddy rice (variety: Tamanishiki) planted in a pot was
treated by spraying 50 ml per pot of the diluted aqueous solution
of the prescribed concentration of the active compound prepared in
the same manner as in the above-mentioned Biological Test Example
1. After the treated rice plant was dried in the air, their foliage
part was cut in 4-5 cm length, which were put in a dish with 9 cm
diameter with a sheet of filter paper and 2 ml of water. Five
larvae of Cnaphalocrocis medinalis Guenee at the second instar were
put in the dish that was placed in a room at the constant
temperature of 25.degree. C. After 2 and 4 days; each rest (each
1/3 amount) of foliage parts of rice plant were cut in the same
manner and added to the dish. After 7 days the number of dead
larvae was counted and the rate of death was calculated. In this
test the results of 2 dishes at 1 section were averaged.
Test Results:
[0678] In the above Biological Test Examples 1 and 2, as specific
examples, the compounds of the aforementioned compound Nos. 8, 9,
10, 11, 12, 13, 14, 15, 16, 45, 47, 48, 49, 51, 52, 53, 81, 82, 83,
84, 85, 86, 87, 88, 89, 90, 91, 93, 103, 107, 116, 128, 132, 137,
138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150,
153, 155, 157, 174, 176, 177, 178, 180, 181, 182, 210, 211, 212,
213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 226, 227, 229,
230, 231, 238, 239, 242, 243, 251, 253, 262, 264, 268, 270, 281,
299, 308, 310, 318, 322, 413, 414, 417, 422, 434, 446, 448, 473,
475, 492, 506, 508, 512, 518, 520, 539, 543, 544, 545, 546, 547,
548, 549, 552, 554, 559, 561, 562, 563, 564, 565, 566, 567, 568,
570, 571, 572, 573, 574, 578, 579, 580, 626, 637, 638, 639, 640,
641, 642, 643, 644, 645, 646, 647, 648, 649, 650, 655, 656, 657,
658, 659, 660, 661, 662, 663, 664, 665, 666, 667, 668, 669, 670,
671, 672, 681, 761, 762, 763, 804 and 920 showed controlling effect
of 100% of rate of death at 20 ppm concentration of the active
component.
Biological Test Example 3
Test Against Myzus persicae Resistant to Organophosphorous Agents
and Carbamates
Test Method:
[0679] About 30 bred Myzus persicae resistant to organophosphorous
agents and carbamates were inoculated per 1 seedling of eggplant
planted in a vinyl pot of 6 cm diameter. One day after the
inoculation, a sufficient amount of a diluted aqueous solution of a
prescribed concentration of an active compound prepared as
mentioned above, was sprayed by using a spray gun. After spraying
it was placed in a green house of 28.degree. C. and the rate of
death was calculated 7 days after the spraying. Test was repeated
twice.
Test Results
[0680] The compounds of the aforementioned compound Nos. 140, 141,
144, 146, 147, 148, 174, 176, 177, 178, 180, 181, 211, 213, 214,
215, 218, 220, 222, 226, 239, 243, 569, 570, 572, 579, 761, 797 and
920 offered to the test as specific examples showed controlling
effect of 100% of rate of death at 100 ppm concentration of the
effective component.
Formulation Example 1
Granule
[0681] To a mixture of 10 parts of the compound of the present
invention (No. 8), 30 parts of bentonite (montmorillonite), 58
parts of talc and 2 parts of ligninsulfonate salt, 25 parts of
water are added, well kneaded, made into granules of 10-40 mesh by
an extrusion granulator and dried at 40-50.degree. C. to obtain
granules.
Formulation Example 2
Granules
[0682] 95 Parts of clay mineral particles having particle diameter
distribution in the range of 0.2-2 mm are put in a rotary mixer.
While rotating it, 5 parts of the compound of the present invention
(No. 11) are sprayed together with a liquid diluent, wetted
uniformly and dried at 40-50.degree. C. to obtain granules.
Formulation Example 3
Emulsifiable Concentrate
[0683] 30 Parts of the compound of the present invention (No. 12),
55 parts of xylene, 8 parts of polyoxyethylene alkyl phenyl ether
and 7 parts of calcium alkylbenzenesulfonate are mixed and stirred
to obtain an emulsifiable concentrate.
Formulation Example 4
Wettable Powder
[0684] 15 Parts of the compound of the present invention (No. 15),
80 parts of a mixture of white carbon (hydrous amorphous silicon
oxide fine powders) and powder clay (1:5), 2 parts of sodium
alkylbenzenesulfonate and 3 parts of sodium
alkylnaphthalenesulfonate-formalin-condensate are crushed and mixed
to make a wettable powder.
Formulation Example 5
Water Dispersible Granule
[0685] 20 Parts of the compound of the present invention (No. 16),
30 parts of sodium ligninsulfonate, 15 parts of bentonite and 35
parts of calcined diatomaceous earth powder are well mixed, added
with water, extruded with 0.3 mm screen and dried to obtain water
dispersible granules.
* * * * *