U.S. patent application number 12/686415 was filed with the patent office on 2010-05-13 for polynucleotides and polypeptides associated with the development of rheumatoid arthritis. This patent application is currently assigned to Bristol-Myers Squibb Company. Invention is credited to Michael Bowen, Julie Carman, Pin Lu, Steven G. Nadler, Michael G. Neubauer.
Application Number | 20100119509 12/686415 |
Document ID | / |
Family ID | 23320510 |
Filed Date | 2010-05-13 |
United States Patent Application | 20100119509 |
Kind Code | A1 |
Carman; Julie ; et al. | May 13, 2010 |
The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
Inventors: | Carman; Julie; (Lawrenceville, NJ) ; Nadler; Steven G.; (Princeton, NJ) ; Bowen; Michael; (Rockville, MD) ; Neubauer; Michael G.; (Skillman, NJ) ; Lu; Pin; (Princeton Jct., NJ) |
Correspondence Address: |
LOUIS J. WILLE;BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT, P O BOX 4000 PRINCETON NJ 08543-4000 US |
Assignee: | Bristol-Myers Squibb
Company |
Family ID: | 23320510 |
Appl. No.: | 12/686415 |
Filed: | January 13, 2010 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
11811442 | Jun 7, 2007 | 7670785 | ||
12686415 | ||||
10308279 | Dec 3, 2002 | 7244573 | ||
11811442 | ||||
60337429 | Dec 3, 2001 | |||
Current U.S. Class: | 424/133.1 ; 435/6.16; 435/7.1; 530/387.3 |
Current CPC Class: | C12Q 1/6883 20130101; A61P 19/02 20180101; C12Q 2600/158 20130101 |
Class at Publication: | 424/133.1 ; 435/6; 435/7.1; 530/387.3 |
International Class: | A61K 39/395 20060101 A61K039/395; C12Q 1/68 20060101 C12Q001/68; G01N 33/53 20060101 G01N033/53; A61P 19/02 20060101 A61P019/02; C07K 16/00 20060101 C07K016/00 |
Sequence CWU 1
1
91163DNAArtificial SequenceSynthetic primer 1ggccagtgaa ttgtaatacg
actcactata gggaggcggt tttttttttt tttttttttt 60ttt 6321316DNAhomo
sapiens 2ggcacgaggc ctcctgagca gtcagcccgc gcgccggccg gctccgttat
ggcgacccgc 60agccctggcg tcgtgattag tgatgatgaa ccaggttatg accttgattt
attttgcata 120cctaatcatt atgctgagga tttggaaagg gtgtttattc
ctcatggact aattatggac 180aggactgaac gtcttgctcg agatgtgatg
aaggagatgg gaggccatca cattgtagcc 240ctctgtgtgc tcaagggggg
ctataaattc tttgctgacc tgctggatta catcaaagca 300ctgaatagaa
atagtgatag atccattcct atgactgtag attttatcag actgaagagc
360tattgtaatg accagtcaac aggggacata aaagtaattg gtggagatga
tctctcaact 420ttaactggaa agaatgtctt gattgtggaa gatataattg
acactggcaa aacaatgcag 480actttgcttt ccttggtcag gcagtataat
ccaaagatgg tcaaggtcgc aagcttgctg 540gtgaaaagga ccccacgaag
tgttggatat aagccagact ttgttggatt tgaaattcca 600gacaagtttg
ttgtaggata tgcccttgac tataatgaat acttcaggga tttgaatcat
660gtttgtgtca ttagtgaaac tggaaaagca aaatacaaag cctaagatga
gagttcaagt 720tgagtttgga aacatctgga gtcctattga catcgccagt
aaaattatca atgttctagt 780tctgtggcca tctgcttagt agagcttttt
gcatgtatct tctaagaatt ttatctgttt 840tgtactttag aaatgtcagt
tgctgcattc ctaaactgtt tatttgcact atgagcctat 900agactatcag
ttccctttgg gcggattgtt gtttaacttg taaatgaaaa aattctctta
960aaccacagca ctattgagtg aaacattgaa ctcatatctg taagaaataa
agagaagata 1020tattagtttt ttaattggta ttttaatttt tatatatgca
ggaaagaata gaagtgattg 1080aatattgtta attataccac cgtgtgttag
aaaagtaaga agcagtcaat tttcacatca 1140aagacagcat ctaagaagtt
ttgttctgtc ctggaattat tttagtagtg tttcagtaat 1200gttgactgta
ttttccaact tgttcaaatt attaccagtg aatctttgtc agcagttccc
1260ttttaaatgc aaatcaataa attcccaaaa atttaaaaaa aaaaaaaaaa aaaaaa
1316320DNAArtificial SequenceSynthetic primer 3ggtatactgc
ctgaccaagg 20422DNAArtificial SequenceSynthetic primer 4cgagatgtga
tgaaggagat gg 22520DNAArtificial SequenceSynthetic primer
5ccccatggaa atcagacagt 20620DNAArtificial SequenceSynthetic primer
6ttgcttttcc gtatgttgtg 20718DNAArtificial SequenceSynthetic primer
7tgaagagcgt cctgggtc 18818DNAArtificial SequenceSynthetic primer
8cgtcgatggt cagcacag 18919DNAArtificial SequenceSynthetic primer
9gcccatcagt gacagcaag 191019DNAArtificial SequenceSynthetic primer
10cccaggcaat gttgaggag 191119DNAArtificial SequenceSynthetic primer
11ccttcccctg tcattgttc 191219DNAArtificial SequenceSynthetic primer
12gacagtaacc ctgccacac 191318DNAArtificial SequenceSynthetic primer
13ggcgactgat ggcgaatc 181418DNAArtificial SequenceSynthetic primer
14caccgtggag cccagaga 181520DNAArtificial SequenceSynthetic primer
15ggcgatgagg tcaatgtaga 201620DNAArtificial SequenceSynthetic
primer 16ctgtgtcctt caccccaaca 201721DNAArtificial
SequenceSynthetic primer 17ggacaccaca aaggcagtga t
211821DNAArtificial SequenceSynthetic primer 18gcagatggag
cacctcacag t 211921DNAArtificial SequenceSynthetic primer
19agctcagctg cttgtctgca t 212020DNAArtificial SequenceSynthetic
primer 20ttcaaagagc tggtgcgaaa 202119DNAArtificial
SequenceSynthetic primer 21ggccagggca atgttatgc 192221DNAArtificial
SequenceSynthetic primer 22acattctggc cctctgatcc t
212319DNAArtificial SequenceSynthetic primer 23ccttcccctg tcattgttc
192419DNAArtificial SequenceSynthetic primer 24gacagtaacc ctgccacac
19251371DNAhomo sapiens 25ctgcaggggg gggggggggc tgggacagtg
aatcgacaat gccgtcttct gtctcgtggg 60gcatcctcct gctggcaggc ctgtgctgcc
tggtccctgt ctccctggct gaggatcccc 120agggagatgc tgcccagaag
acagatacat cccaccatga tcaggatcac ccaaccttca 180acaagatcac
ccccaacctg gctgagttcg ccttcagcct ataccgccag ctggcacacc
240agtccaacag caccaatatc ttcttctccc cagtgagcat cgctacagcc
tttgcaatgc 300tctccctggg gaccaaggct gacactcacg atgaaatcct
ggagggcctg aatttcaacc 360tcacggagat tccggaggct cagatccatg
aaggcttcca ggaactcctc cgtaccctca 420accagccaga cagccagctc
cagctgacca ccggcaatgg cctgttcctc agcgagggcc 480tgaagctagt
ggataagttt ttggaggatg ttaaaaagtt gtaccactca gaagccttca
540ctgtcaactt cggggacacc gaagaggcca agaaacagat caacgattac
gtggagaagg 600gtactcaagg gaaaattgtg gatttggtca aggagcttga
cagagacaca gtttttgctc 660tggtgaatta catcttcttt aaaggcaaat
gggagagacc ctttgaagtc aaggacaccg 720aggaagagga cttccacgtg
gaccaggtga ccaccgtgaa ggtgcctatg atgaagcgtt 780taggcatgtt
taacatccag cactgtaaga agctgtccag ctgggtgctg ctgatgaaat
840acctgggcaa tgccaccgcc atcttcttcc tgcctgatga ggggaaacta
cagcacctgg 900aaaatgaact cacccacgat atcatcacca agttcctgga
aaatgaagac agaaggtctg 960ccagcttaca tttacccaaa ctgtccatta
ctggaaccta tgatctgaag agcgtcctgg 1020gtcaactggg catcactaag
gtcttcagca atggggctga cctctccggg gtcacagagg 1080aggcacccct
gaagctctcc aaggccgtgc ataaggctgt gctgaccatc gacgagaaag
1140ggactgaagc tgctggggcc atgtttttag aggccatacc catgtctatc
ccccccgagg 1200tcaagttcaa caaacccttt gtcttcttaa tgattgaaca
aaataccaag tctcccctct 1260tcatgggaaa agtggtgaat cccacccaaa
aataactgcc tctcgctcct caacccctcc 1320cctccatccc tggccccctc
cctggatgac attaaagaag ggttgagctg g 137126417PRThomo sapiens 26Met
Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Ala Gly Leu Cys Cys1 5 10
15Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala Gln20
25 30Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
Lys35 40 45Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg
Gln Leu50 55 60Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro
Val Ser Ile65 70 75 80Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr
Lys Ala Asp Thr His85 90 95Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn
Leu Thr Glu Ile Pro Glu100 105 110Ala Gln Ile His Glu Gly Phe Gln
Glu Leu Leu Arg Thr Leu Asn Gln115 120 125Pro Asp Ser Gln Leu Gln
Leu Thr Thr Gly Asn Gly Leu Phe Leu Ser130 135 140Glu Gly Leu Lys
Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys Leu145 150 155 160Tyr
His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp His Glu Glu Ala165 170
175Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys
Ile180 185 190Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe
Ala Leu Val195 200 205Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg
Pro Phe Glu Val Lys210 215 220Asp Thr Glu Asp Glu Asp Phe His Val
Asp Gln Val Thr Thr Val Lys225 230 235 240Val Pro Met Met Lys Arg
Leu Gly Met Phe Asn Ile Gln His Cys Lys245 250 255Lys Leu Ser Ser
Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala Thr260 265 270Ala Ile
Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu Asn275 280
285Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp
Arg290 295 300Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr
Gly Thr Tyr305 310 315 320Asp Leu Lys Ser Val Leu Gly Gln Leu Gly
Ile Thr Lys Val Phe Ser325 330 335Asn Gly Ala Asp Leu Ser Gly Val
Thr Glu Glu Ala Pro Leu Lys Leu340 345 350Ser Lys Ala Val His Lys
Ala Val Leu Thr Ile Asp Glu Lys Gly Thr355 360 365Glu Ala Ala Gly
Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro370 375 380Pro Glu
Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln385 390 395
400Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr
Gln405 410 415Lys27858DNAHomo Sapiens 27atggatgact ccacagaaag
ggagcagtca cgccttactt cttgccttaa gaaaagagaa 60gaaatgaaac tgaaggagtg
tgtttccatc ctcccacgga aggaaagccc ctctgtccga 120tcctccaaag
acggaaagct gctggctgca accttgctgc tggcactgct gtcttgctgc
180ctcacggtgg tgtctttcta ccaggtggcc gccctgcaag gggacctggc
cagcctccgg 240gcagagctgc agggccacca cgcggagaag ctgccagcag
gagcaggagc ccccaaggcc 300ggcttggagg aagctccagc tgtcaccgcg
ggactgaaaa tctttgaacc accagctcca 360ggagaaggca actccagtca
gaacagcaga aataagcgtg ccgttcaggg tccagaagaa 420acagtcactc
aagactgctt gcaactgatt gcagacagtg aaacaccaac tatacaaaaa
480ggatcttaca catttgttcc atggcttctc agctttaaaa ggggaagtgc
cctagaagaa 540aaagagaata aaatattggt caaagaaact ggttactttt
ttatatatgg tcaggtttta 600tatactgata agacctacgc catgggacat
ctaattcaga ggaagaaggt ccatgtcttt 660ggggatgaat tgagtctggt
gactttgttt cgatgtattc aaaatatgcc tgaaacacta 720cccaataatt
cctgctattc agctggcatt gcaaaactgg aagaaggaga tgaactccaa
780cttgcaatac caagagaaaa tgcacaaata tcactggatg gagatgtcac
attttttggt 840gcattgaaac tgctgtga 85828285PRThomo sapiens 28Met Asp
Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu1 5 10 15Lys
Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro20 25
30Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu35
40 45Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val
Val50 55 60Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser
Leu Arg65 70 75 80Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro
Ala Gly Ala Gly85 90 95Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala
Val Thr Ala Gly Leu100 105 110Lys Ile Phe Glu Pro Pro Ala Pro Gly
Glu Gly Asn Ser Ser Gln Asn115 120 125Ser Arg Asn Lys Arg Ala Val
Gln Gly Pro Glu Glu Thr Val Thr Gln130 135 140Asp Cys Leu Gln Leu
Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys145 150 155 160Gly Ser
Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser165 170
175Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly
Tyr180 185 190Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr
Tyr Ala Met195 200 205Gly His Leu Ile Gln Arg Lys Lys Val His Val
Phe Gly Asp Glu Leu210 215 220Ser Leu Val Thr Leu Phe Arg Cys Ile
Gln Asn Met Pro Glu Thr Leu225 230 235 240Pro Asn Asn Ser Cys Tyr
Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly245 250 255Asp Glu Leu Gln
Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu260 265 270Asp Gly
Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu275 280 285291128DNAhomo
sapiens 29atgtggttct tgacaactct gctcctttgg gttccagttg atgggcaagt
ggacaccaca 60aaggcagtga tcactttgca gcctccatgg gtcagcgtgt tccaagagga
aaccgtaacc 120ttgcactgtg aggtgctcca tctgcctggg agcagctcta
cacagtggtt tctcaatggc 180acagccactc agacctcgac ccccagctac
agaatcacct ctgccagtgt caatgacagt 240ggtgaataca ggtgccagag
aggtctctca gggcgaagtg accccataca gctggaaatc 300cacagaggct
ggctactact gcaggtctcc agcagagtct tcacggaagg agaacctctg
360gccttgaggt gtcatgcgtg gaaggataag ctggtgtaca atgtgcttta
ctatcgaaat 420ggcaaagcct ttaagttttt ccactggaat tctaacctca
ccattctgaa aaccaacata 480agtcacaatg gcacctacca ttgctcaggc
atgggaaagc atcgctacac atcagcagga 540atatctgtca ctgtgaaaga
gctatttcca gctccagtgc tgaatgcatc tgtgacatcc 600ccactcctgg
aggggaatct ggtcaccctg agctgtgaaa caaagttgct cttgcagagg
660cctggtttgc agctttactt ctccttctac atgggcagca agaccctgcg
aggcaggaac 720acatcctctg aataccaaat actaactgct agaagagaag
actctgggtt atactggtgc 780gaggctgcca cagaggatgg aaatgtcctt
aagcgcagcc ctgagttgga gcttcaagtg 840cttggcctcc agttaccaac
tcctgtctgg tttcatgtcc ttttctatct ggcagtggga 900ataatgtttt
tagtgaacac tgttctctgg gtgacaatac gtaaagaact gaaaagaaag
960aaaaagtggg atttagaaat ctctttggat tctggtcatg agaagaaggt
aatttccagc 1020cttcaagaag acagacattt agaagaagag ctgaaatgtc
aggaacaaaa agaagaacag 1080ctgcaggaag gggtgcaccg gaaggagccc
cagggggcca cgtagcag 112830374PRThomo sapiens 30Met Trp Phe Leu Thr
Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln1 5 10 15Val Asp Thr Thr
Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser20 25 30Val Phe Gln
Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu35 40 45Pro Gly
Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln50 55 60Thr
Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser65 70 75
80Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile85
90 95Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser
Arg100 105 110Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His
Ala Trp Lys115 120 125Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg
Asn Gly Lys Ala Phe130 135 140Lys Phe Phe His Trp Asn Ser Asn Leu
Thr Ile Leu Lys Thr Asn Ile145 150 155 160Ser His Asn Gly Thr Tyr
His Cys Ser Gly Met Gly Lys His Arg Tyr165 170 175Thr Ser Ala Gly
Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro180 185 190Val Leu
Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val195 200
205Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu
Gln210 215 220Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg
Gly Arg Asn225 230 235 240Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala
Arg Arg Glu Asp Ser Gly245 250 255Leu Tyr Trp Cys Glu Ala Ala Thr
Glu Asp Gly Asn Val Leu Lys Arg260 265 270Ser Pro Glu Leu Glu Leu
Gln Val Leu Gly Leu Gln Leu Pro Thr Pro275 280 285Val Trp Phe His
Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu290 295 300Val Asn
Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys Arg Lys305 310 315
320Lys Lys Trp Asp Leu Glu Ile Ser Leu Asp Ser Gly His Glu Lys
Lys325 330 335Val Ile Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu
Glu Leu Lys340 345 350Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu
Gly Val His Arg Lys355 360 365Glu Pro Gln Gly Ala
Thr37031586DNAhomo sapiens 31aaaacactct gtgtggctcc tcggctttga
cagagtgcaa gacgatgact tgcaaaatgt 60cgcagctgga acgcaacata gagaccatca
tcaacacctt ccaccaatac tctgtgaagc 120tggggcaccc agacaccctg
aaccaggggg aattcaaaga gctggtgcga aaagatctgc 180aaaattttct
caagaaggag aataagaatg aaaaggtcat agaacacatc atggaggacc
240tggacacaaa tgcagacaag cagctgagct tcgaggagtt catcatgctg
atggcgaggc 300taacctgggc ctcccacgag aagatgcacg agggtgacga
gggccctggc caccaccata 360agccaggcct cggggagggc accccctaag
accacagtgg ccaagatcac agtggccacg 420gccacggcca cagtcatggt
ggccacggcc acagccacta atcaggaggc caggccaccc 480tgcctctacc
caaccagggc cccggggcct gttatgtcaa actgtcttgg ctgtggggct
540aggggctggg gccaaataaa gtctcttcct ccaagtcagt gctctg
58632114PRThomo sapiens 32Met Thr Cys Lys Met Ser Gln Leu Glu Arg
Asn Ile Glu Thr Ile Ile1 5 10 15Asn Thr Phe His Gln Tyr Ser Val Lys
Leu Gly His Pro Asp Thr Leu20 25 30Asn Gln Gly Glu Phe Lys Glu Leu
Val Arg Lys Asp Leu Gln Asn Phe35 40 45Leu Lys Lys Glu Asn Lys Asn
Glu Lys Val Ile Glu His Ile Met Glu50 55 60Asp Leu Asp Thr Asn Ala
Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile65 70 75 80Met Leu Met Ala
Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu85 90 95Gly Asp Glu
Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly100 105 110Thr
Pro331970DNAhomo sapiens 33atattggagc agcaagaggc tgggaagcca
tcacttacct tgcactgaga aagaagacaa 60aggccagtat gcacagcttt cctccactgc
tgctgctgct gttctggggt gtggtgtctc 120acagcttccc agcgactcta
gaaacacaag agcaagatgt ggacttagtc cagaaatacc 180tggaaaaata
ctacaacctg aagaatgatg ggaggcaagt tgaaaagcgg agaaatagtg
240gcccagtggt tgaaaaattg aagcaaatgc aggaattctt tgggctgaaa
gtgactggga 300aaccagatgc tgaaaccctg aaggtgatga agcagcccag
atgtggagtg cctgatgtgg 360ctcagtttgt cctcactgag ggaaaccctc
gctgggagca aacacatctg aggtacagga 420ttgaaaatta
cacgccagat ttgccaagag cagatgtgga ccatgccatt gagaaagcct
480tccaactctg gagtaatgtc acacctctga cattcaccaa ggtctctgag
ggtcaagcag 540acatcatgat atcttttgtc aggggagatc atcgggacaa
ctctcctttt gatggacctg 600gaggaaatct tgctcatgct tttcaaccag
gcccaggtat tggaggggat gctcattttg 660atgaagatga aaggtggacc
aacaatttca gagagtacaa cttacatcgt gttgcggctc 720atgaactcgg
ccattctctt ggactctccc attctactga tatcggggct ttgatgtacc
780ctagctacac cttcagtggt gatgttcagc tagctcagga tgacattgat
ggcatccaag 840ccatatatgg acgttcccaa aatcctgtcc agcccatcgg
cccacaaacc ccaaaagcgt 900gtgacagtaa gctaaccttt gatgctataa
ctacgattcg gggagaagtg atgttcttta 960aagacagatt ctacatgcgc
acaaatccct tctacccgga agttgagctc aatttcattt 1020ctgttttctg
gccacaactg ccaaatgggc ttgaagctgc ttacgaattt gccgacagag
1080atgaagtccg gtttttcaaa gggaataagt actgggctgt tcagggacag
aatgtgctac 1140acggataccc caaggacatc tacagctcct ttggcttccc
tagaactgtg aagcatatcg 1200atgctgctct ttctgaggaa aacactggaa
aaacctactt ctttgttgct aacaaatact 1260ggaggtatga tgaatataaa
cgatctatgg atccaagtta tcccaaaatg atagcacatg 1320actttcctgg
aattggccac aaagttgatg cagttttcat gaaagatgga tttttctatt
1380tctttcatgg aacaagacaa tacaaatttg atcctaaaac gaagagaatt
ttgactctcc 1440agaaagctaa tagctggttc aactgcagga aaaattgaac
attactaatt tgaatggaaa 1500acacatggtg tgagtccaaa gaaggtgttt
tcctgaagaa ctgtctattt tctcagtcat 1560ttttaacctc tagagtcact
gatacacaga atataatctt atttatacct cagtttgcat 1620atttttttac
tatttagaat gtagcccttt ttgtactgat ataatttagt tccacaaatg
1680gtgggtacaa aaagtcaagt ttgtggctta tggattcata taggccagag
ttgcaaagat 1740cttttccaga gtatgcaact ctgacgttga tcccagagag
cagcttcagt gacaaacata 1800tcctttcaag acagaaagag acaggagaca
tgagtctttg ccggaggaaa agcagctcaa 1860gaacacatgt gcagtcactg
gtgtcaccct agataggcaa gggataactc ttctaacaca 1920aaataagtgt
tttatgtttg gaataaagtc aaccttgttt ctactgtttt 197034469PRThomo
sapiens 34Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly
Val Val1 5 10 15Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln
Asp Val Asp20 25 30Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu
Lys Asn Asp Gly35 40 45Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro
Val Val Glu Lys Leu50 55 60Lys Gln Met Gln Glu Phe Phe Gly Leu Lys
Val Thr Gly Lys Pro Asp65 70 75 80Ala Glu Thr Leu Lys Val Met Lys
Gln Pro Arg Cys Gly Val Pro Asp85 90 95Val Ala Gln Phe Val Leu Thr
Glu Gly Asn Pro Arg Trp Glu Gln Thr100 105 110His Leu Thr Tyr Arg
Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala115 120 125Asp Val Asp
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val130 135 140Thr
Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met145 150
155 160Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp
Gly165 170 175Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro
Gly Ile Gly180 185 190Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp
Thr Asn Asn Phe Arg195 200 205Glu Tyr Asn Leu His Arg Val Ala Ala
His Glu Leu Gly His Ser Leu210 215 220Gly Leu Ser His Ser Thr Asp
Ile Gly Ala Leu Met Tyr Pro Ser Tyr225 230 235 240Thr Phe Ser Gly
Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile245 250 255Gln Ala
Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro260 265
270Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile
Thr275 280 285Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe
Tyr Met Arg290 295 300Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn
Phe Ile Ser Val Phe305 310 315 320Trp Pro Gln Leu Pro Asn Gly Leu
Glu Ala Ala Tyr Glu Phe Ala Asp325 330 335Arg Asp Glu Val Arg Phe
Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln340 345 350Gly Gln Asn Val
Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe355 360 365Gly Phe
Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu370 375
380Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg
Tyr385 390 395 400Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro
Lys Met Ile Ala405 410 415His Asp Phe Pro Gly Ile Gly His Lys Val
Asp Ala Val Phe Met Lys420 425 430Asp Gly Phe Phe Tyr Phe Phe His
Gly Thr Arg Gln Tyr Lys Phe Asp435 440 445Pro Lys Thr Lys Arg Ile
Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe450 455 460Asn Cys Arg Lys
Asn465352995DNAhomo sapiens 35tcttcctcag catttcctgc caaccctttt
ctggtttctg tttcttcaac ctctttttgt 60tttatggtcc cttttatggt attttctctt
atttctagga aaacattaat gataggtttt 120tgaacacttc ccctgagtag
tctctgttgc aggttgcttt tttgtttgct ctgccctctg 180tctttcatac
tagaggcctt gctcaaatgt ctggtgacct tggcaatgtg ctaatattta
240aaaaccaaga acaaaaaaat taattggtaa ccctgaacat gagtggagct
tgtcaactgg 300atttcacttt ttgatagtct ggcagagact ttttcttcag
gaacttccag cgacaatatc 360tttaaagctt ttttcttgag ccaatcagat
tctctgagaa gttgcttcct atcttctgcc 420cggaaagaaa aatcttgtct
ggcagcattc tcgcagctag gtgatgacta aagcagggat 480ttttaccatt
cagtatggaa gcttttgttt aattcacctg tttttcacct gatttccatc
540agtcccaagt tgatctctta cactctttct agagactaga ccttactctg
ctgctgaaaa 600gaaagaagag agagaattgg taaaagggtt ttgagactct
acttcataaa caagctttaa 660accagttctt atatctacag cctatcttta
ccctcatttc cagaagtacc tggtgctgtc 720aattcctgtg ctatttggag
tttcaagata taaatcaggt tatttcttgg ttttctccat 780ggatagctta
ggatttagct ttctctgctc tgtaaagcta tccatcttac tttctaagct
840ttcaaatttt tggtagggtt ttctctttcc ctatttggct ttgtatattg
atgtcttttt 900tattttttta ctgccattgg agagggtttt caggaaggag
cagaggctaa tgcatgcgtg 960tcacttacta tctttaactg caagttcaat
tctaattaat atctattcca tttgcatcac 1020aattgattca tgatctcaga
tgactcacag agattttacc tacagctgtt atctaggctc 1080ctttatctat
ttttccttcc cggatattgt ttagattcca ttggcttaca tcgagtagag
1140aacatcagcc atacggaacc tgctgtgagc cttcacttgt acagtccacc
ttttgataca 1200tgccatgcct ttgatcaaag aacaggacat aaaaacaaag
tcacaatgac attccatagt 1260aaatttggaa tcagaactcc aaatgtgagt
ataatttctt ctaggtttaa atgctctgta 1320ggttggcact gttacactgc
atgtatgcaa agaatgagat gagtcttaat tcatggataa 1380ggcccaatat
atcttgattg ttttatttaa ctttagcgac tatcttttca atttattttt
1440aaaaacttat tatgttagat ccaaacatta gttgagaaat ttcaaaatgt
atgcttgttt 1500ttaaagaaaa tgttttcatt tacttgggaa atgagagtga
aaactattat ttgatataac 1560tgttactgcc atggcttact atgcataggt
ctaatttgct gggccaacag ggataagttg 1620cataattaac ctttgtaaag
gttattggct gatgatataa ctaaagcaaa ttgtctgttt 1680tgtttgccaa
tgttgcttat tcttagagtt gttatgccat ttataccaca aataagaata
1740gactatacta acatgttcct ccttgagaaa caagcatttc ctaccaaaaa
taaaaaggca 1800accaacacta atatagcagg gcagtcttct acctctgaaa
taagtttgtc atttagagga 1860atagtcttta attatcagaa tatccagaaa
tagacaatgt gtgaaaatgg agacccaagc 1920aatccttgag tcttaatgaa
agcgcagcct ctgagggaag ccagggcaga attttctcat 1980tatcgctccg
cttcatcttt atcttccaca ttccaaaccc taagagatat tcttattgcg
2040ggaaaaacaa caaggctccc ttgcccttgc tgagttttca tacactgcta
caaaagcaga 2100actatttaga aggagttaaa atgtcttttg taaagtttct
tacacagctt tctttttttc 2160ccttttttac aggcaacttc gggctcgctg
gagaacaact aaggggcacc aaagccctct 2220gaggttttac tttaaggttc
gctgtatgtt tgccttggac aaaaaggcta cctaccacgt 2280gctatccagt
aatatactta aataagccaa tacttagatc tactgtaagg cagatgctaa
2340ttataaggca ttaagtaagc aaatagtgcc ctcagctact gcagaagaaa
agtcccactg 2400aggaaaagaa agtcttgtga tttttaaagg caagttttca
agtgctctca tagttctatc 2460ctctaattcc attaaatcca tactaggagc
gtcagtgagg gttttcatag cttttggaaa 2520tactttggtc tctgaactgt
aattagcgca agaagtaaaa acagaaacgt caaacgtcaa 2580atgtttgctt
tgttacctgg aggactaaat gtagatgtct ttagtatact ttgtatgttc
2640ttaaatattg gaagataatt ttgtgaatct gtagatttta ttttttcagt
cttaccttac 2700aaatttcttt tctatgaata atagaggaac tcacggcact
ctgccacttg ttaatgaaag 2760gaagtgcaga ggatttagaa aagtacatga
tccccagacc acaacaaacc aaaacataaa 2820ctcatgtctg tgtcccatgg
tcatagtcaa agattttgta ctgctaaaat taccaaataa 2880tttaaataaa
gtggatttga acacaatttg aaggtgtctt tctgattaac atgatagaaa
2940cttcacataa atcagtttct tagatctaga tatacaaaag cactgtgaca aatgg
299536200PRThomo sapiens 36Met Glu Gln Thr Glu Val Leu Lys Pro Arg
Thr Leu Ala Asp Leu Ile1 5 10 15Arg Ile Leu His Gln Leu Phe Ala Gly
Asp Glu Val Asn Val Glu Glu20 25 30Val Gln Ala Ile Met Glu Ala Tyr
Glu Ser Asp Pro Ile Glu Trp Ala35 40 45Met Tyr Ala Lys Phe Asp Gln
Tyr Arg Tyr Thr Arg Asn Leu Val Asp50 55 60Gln Gly Asn Gly Lys Phe
Asn Leu Met Ile Leu Cys Trp Gly Glu Gly65 70 75 80His Gly Ser Ser
Ile His Asp His Thr Asn Ser His Cys Phe Leu Lys85 90 95Met Leu Gln
Gly Asn Leu Lys Glu Thr Leu Phe Ala Trp Pro Asp Lys100 105 110Lys
Ser Asn Glu Met Val Lys Lys Ser Glu Arg Val Leu Arg Glu Asn115 120
125Gln Cys Ala Tyr Ile Asn Asp Ser Ile Gly Leu His Arg Val Glu
Asn130 135 140Ile Ser His Thr Glu Pro Ala Val Ser Leu His Leu Tyr
Ser Pro Pro145 150 155 160Phe Asp Thr Cys His Ala Phe Asp Gln Arg
Thr Gly His Lys Asn Lys165 170 175Val Thr Met Thr Phe His Ser Lys
Phe Gly Ile Arg Thr Pro Asn Ala180 185 190Thr Ser Gly Ser Leu Glu
Asn Asn195 200371763DNAhomo sapiens 37gcactggact gagaaccttc
accaaaaaaa tgtctgccca gagacagatg aggtccttca 60gctccagtgc tgattggttc
ttttccaaag gcccatctaa tcctaccacg cacggaaata 120tccacaggtt
tttattcttt ctgccagcta catcagatcc atcaggtccg agctgagttg
180actaccacta cttttccctt tgtctcaatt atgtcttgga agaaggcttt
gcggatcccc 240ggaggccttc gggcaccaac tgtgaccttg atgctggcga
tgctgagcac cccagtggct 300gagggcagag accctcccga ggatttcgtg
ctccagttta aggccatgtg ctacttcacc 360aatgggacgg agcgcgtgcg
ttatgtgacc agatacatct ataaccgaga ggaggacgtg 420cgcttcgaca
gcgacgtggg ggtgtatcgg gcggtgacgg cgcaggggcg gcctgacgcc
480gagtactgga acagccagaa ggacatcctg gagaggaccc gagcggagtt
ggacacggtg 540tgcagacaca actacgaggt ggcgttccgc gggatcttgc
agaggagagt ggagcccaca 600gtgaccatct ccccatccag gacagaggcc
ctcaaccacc acaacctgct ggtctgctcg 660gtgacagatt tctatccagg
ccagatcaaa gtccggtggt ttcggaatga ccaggaggag 720acagctggcg
ttgtgtccac cccccttatt aggaacggtg actggacctt ccagatcctg
780gtgatgctgg aaatgactcc ccagcatgga gacgtctaca cctgccacgt
ggagcacccc 840agcctccaga gccccatcac cgtggagtgg cgggctcagt
ctgaatctgc ccagaacaag 900atgctgagtg gcattggagg cttcgtgctg
gggctgatct tcctcgggct gggccttatc 960atccgtcaaa ggagtcagaa
aggacctcaa gggcctccac cagcagggct tctgcactga 1020ctcctgagac
tattttaact aggattggtt atcactcttc tgtgatgcct gcttgtgcct
1080gcccagaatt cccagctgcc tgtgtcagct tgtcccccga gatcaaagtc
ctacagtggc 1140tgtcacgcag ccaccaggtc atctcctttc atccccaccc
caaggcgctg gctgtgactc 1200tgcttcctgc actgacccag agcctctgcc
tgtgcacggc cagctgcgtc tactcaggtc 1260ccaaggggtt tctgtttcta
ttctctcctc agactgctca agagaagcac atgaaaaaca 1320ttacctgact
ttagagcttt tttacataat taaacatgat cctgagttaa aaaaaaaaaa
1380ggaaatcgct gcagaatgaa ggaatatccc ttgaggtgac ccagccaacc
tgtggccaga 1440aggagggttg taccttgaaa agaccactga aagcattttg
gggtgtcaag taagggtggg 1500cagaggaggt agaaaatcaa ttcaattgtc
gcatcattca tggttcttta atattgatgc 1560tcagtgcatt ggccttagaa
tatcccagcc tctcttctgg tttggtgagt gctgtgtaag 1620taagcatggt
agaattgttt ggagacatat atagtgatcc ttggtcactg gtgtttcaaa
1680cattctggaa agtcacatcg atcaagaata ttttttattt ttaagaaagc
ataaccagca 1740ataaaaatac tatttttgag tct 176338269PRThomo sapiens
38Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Pro1
5 10 15Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu
Gly20 25 30Arg Asp Pro Pro Glu Asp Phe Val Leu Gln Phe Lys Ala Met
Cys Tyr35 40 45Phe Thr Asn Gly Thr Glu Arg Val Arg Tyr Val Thr Arg
Tyr Ile Tyr50 55 60Asn Arg Glu Glu Asp Val Arg Phe Asp Ser Asp Val
Gly Val Tyr Arg65 70 75 80Ala Val Thr Ala Gln Gly Arg Pro Asp Ala
Glu Tyr Trp Asn Ser Gln85 90 95Lys Asp Ile Leu Glu Arg Thr Arg Ala
Glu Leu Asp Thr Val Cys Arg100 105 110His Asn Tyr Glu Val Ala Phe
Arg Gly Ile Leu Gln Arg Arg Val Glu115 120 125Pro Thr Val Thr Ile
Ser Pro Ser Arg Thr Glu Ala Leu Asn His His130 135 140Asn Leu Leu
Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys145 150 155
160Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val
Ser165 170 175Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile
Leu Val Met180 185 190Leu Glu Met Thr Pro Gln His Gly Asp Val Tyr
Thr Cys His Val Glu195 200 205His Pro Ser Leu Gln Ser Pro Ile Thr
Val Glu Trp Arg Ala Gln Ser210 215 220Glu Ser Ala Gln Asn Lys Met
Leu Ser Gly Ile Gly Gly Phe Val Leu225 230 235 240Gly Leu Ile Phe
Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Gln245 250 255Lys Gly
Pro Gln Gly Pro Pro Pro Ala Gly Leu Leu His260 265391404DNAhomo
sapiens 39gaattcggct gtcgcactta ctgttcaata gtatatactc tgtatttgaa
aaatagatgt 60atatattcta ggtgataaat taaaaatgaa agaatttaat cattggaaag
tattaaatat 120atattgctta tcttctccaa ggaagaggag ttctctcgta
cccatccaaa ctgacctaat 180tctcaagctg cttcatcttg cttgtactgt
aggttcattt gcaatttgta gattatgctc 240cttcaggatt ggcttttgta
aatttctgtt agaagctggt ttctgcattt ttgatttttg 300tgtatttgga
tacattttca tattgtgcag agaaatccat gagttaaaaa attatttttc
360cctgttttat ttctgcatga acctaagtca cattgaccca gtaattgata
tatgtgtgat 420tattgcaatt aagtataaga aggtagaata tatagtttta
ttagacagat gcttcctgaa 480atattatttt gtatgttttt actatatcct
ttttgtgtat ctacagatac aacagacatg 540caagagaatg gactcagaaa
tatgcaatgt aaaaatcaaa aacattttca tatataacca 600gagtactgta
aaatctaggt tttttttcaa cattagcagt aaattgagca ctgtttacct
660gtttcattgt accatgaaac catttgattt ttaccatttt aaatgtgtct
caagcaagac 720aaaacaaact tccaaaaata cccttaagac tgtgatgaga
gcatttatca ttttgtatgc 780attgagaaag acatttatta tggtttttaa
gatacttgga catctgcatc ttcagcttac 840aagatctaca atgcagctga
aaaagcaacc aaattatttt ttgctgaaaa ctagatgttt 900tttacatgag
aaaatactgt atgtgtgtct aagatgtcag ttttataaat ctgtattcag
960atttcatcct ttgttagctc actttataat ttgtattttt tttctgtata
gaactaaata 1020tattctattt acatgtatgt caactcatta cttttttcct
gtgaacagta ttgaaaaccc 1080caaccggctg ataattaagt gaattaactg
tgtctccctt gtcttaggat attctgtaga 1140ttgattgcag atttcttaaa
tctgaaatga ctttacactg taattctcag catactgatt 1200atggagaaca
cttgttttga attttgttat acttgactta actttattgc aatgtgaatt
1260aattgactgc taagtaggaa gatgtgtaac ttttatttgt tgctattcac
atttgaattt 1320tttcctgtat aggcaatatt atattgacac cttttacaga
tcttactgta gcaaaaacca 1380tataaataaa atgctttttc tgct
140440338PRThomo sapiens 40Met Lys Glu Phe Asn His Trp Lys Val Leu
Asn Ile Tyr Cys Leu Ser1 5 10 15Ser Pro Arg Lys Arg Ser Ser Leu Val
Pro Ile Gln Thr Asp Leu Ile20 25 30Leu Lys Leu Leu His Leu Ala Cys
Thr Val Gly Ser Phe Ala Ile Cys35 40 45Arg Leu Cys Ser Phe Arg Ile
Gly Phe Cys Lys Phe Leu Leu Glu Ala50 55 60Gly Phe Cys Ile Phe Asp
Phe Cys Val Phe Gly Tyr Ile Phe Ile Leu65 70 75 80Cys Arg Glu Ile
His Glu Leu Lys Asn Tyr Phe Ser Leu Phe Tyr Phe85 90 95Cys Met Asn
Leu Ser His Ile Asp Pro Val Ile Asp Ile Cys Val Ile100 105 110Ile
Ala Ile Lys Tyr Lys Lys Val Glu Tyr Ile Val Leu Leu Asp Arg115 120
125Cys Phe Leu Lys Tyr Tyr Phe Val Cys Phe Tyr Tyr Ile Leu Phe
Val130 135 140Tyr Leu Gln Ile Gln Gln Thr Cys Lys Arg Met Asp Ser
Glu Ile Cys145 150 155 160Asn Val Lys Ile Lys Asn Ile Phe Ile Tyr
Asn Gln Ser Thr Val Lys165 170 175Ser Arg Phe Phe Phe Asn Ile Ser
Ser Lys Leu Ser Thr Val Tyr Leu180 185 190Phe His Cys Thr Met Lys
Pro Phe Asp Phe Tyr His Phe Lys Cys Val195 200 205Ser Ser Lys Thr
Lys Gln Thr Ser Lys Asn Thr Leu Lys Thr Val Met210 215 220Arg Ala
Phe Ile Ile Leu Tyr Ala Leu Arg Lys Thr Phe Ile Met Val225 230 235
240Phe Lys Ile Leu Gly His Leu His Leu Gln Leu Thr Arg Ser Thr
Met245 250 255Gln Leu Lys Lys Gln Pro Asn Tyr Phe Leu Leu Lys Thr
Arg Cys Phe260 265 270Leu His Glu Lys Ile Leu Tyr Val Cys Leu Arg
Cys Gln Phe Tyr Lys275 280 285Ser Val Phe Arg Phe His Pro Leu Leu
Ala His Phe Ile Ile Cys Ile290 295 300Phe Phe Leu Tyr Arg Thr Lys
Tyr Ile Leu Phe Thr Cys Met Ser Thr305 310 315 320His Tyr Phe Phe
Pro Val Asn Ser Ile
Glu Asn Pro Asn Arg Leu Ile325 330 335Ile Lys412881DNAhomo sapiens
41acagaagtgc tagaagccag tgctcgtgaa ctaaggagaa aaagaacaga caagggaaca
60gcctggacat ggcatcagag atccacatga caggcccaat gtgcctcatt gagaacacta
120atgggcgact gatggcgaat ccagaagctc tgaagatcct ttctgccatt
acacagccta 180tggtggtggt ggcaattgtg ggcctctacc gcacaggcaa
atcctacctg atgaacaagc 240tggctggaaa gaaaaagggc ttctctctgg
gctccacggt gcagtctcac actaaaggaa 300tctggatgtg gtgtgtgccc
caccccaaga agccaggcca catcctagtt ctgctggaca 360ccgagggtct
gggagatgta gagaagggtg acaaccagaa tgactcctgg atcttcgccc
420tggccgtcct cctgagcagc accttcgtgt acaatagcat aggaaccatc
aaccagcagg 480ctatggacca actgtactat gtgacagagc tgacacatag
aatccgatca aaatcctcac 540ctgatgagaa tgagaatgag gttgaggatt
cagctgactt tgtgagcttc ttcccagact 600ttgtgtggac actgagagat
ttctccctgg acttggaagc agatggacaa cccctcacac 660cagatgagta
cctgacatac tccctgaagc tgaagaaagg taccagtcaa aaagatgaaa
720cttttaacct gcccagactc tgtatccgga aattcttccc aaagaaaaaa
tgctttgtct 780ttgatcggcc cgttcaccgc aggaagcttg cccagctcga
gaaactacaa gatgaagagc 840tggaccccga atttgtgcaa caagtagcag
acttctgttc ctacatcttt agtaattcca 900aaactaaaac tctttcagga
ggcatccagg tcaacgggcc tcgtctagag agcctggtgc 960tgacctacgt
caatgccatc agcagtgggg atctgccgtg catggagaac gcagtcctgg
1020ccttggccca gatagagaac tcagctgcag tgcaaaaggc tattgcccac
tatgaacagc 1080agatgggcca gaaggtgcag ctgcccacag aaagcctcca
ggagctgctg gacctgcaca 1140gggacagtga gagagaggcc attgaagtct
tcatcaggag ttccttcaaa gatgtggacc 1200atctatttca aaaggagtta
gcggcccagc tagaaaaaaa gcgggatgac ttttgtaaac 1260agaatcagga
agcatcatca gatcgttgct caggtttact tcaggtcatt ttcagtcctc
1320tagaagaaga agtgaaggcg ggaatttatt cgaaaccagg gggctatcgt
ctctttgttc 1380agaagctaca agacctgaag aaaaagtact atgaggaacc
gaggaagggg atacaggctg 1440aagagattct gcagacatac ttgaaatcca
aggagtctat gactgatgca attctccaga 1500cagaccagac tctcacagaa
aaagaaaagg agattgaagt ggaacgtgtg aaagctgagt 1560ctgcacaggc
ttcagcaaaa atgttgcagg aaatgcaaag aaagaatgag cagatgatgg
1620aacagaagga gaggagttat caggaacact tgaaacaact gactgagaag
atggagaacg 1680acagggtcca gttgctgaaa gagcaagaga ggaccctcgc
tcttaaactt caggaacagg 1740agcaactact aaaagaggga tttcaaaaag
aaagcagaat aatgaaaaat gagatacagg 1800atctccagac gaaaatgaga
cgacgaaagg catgtaccat aagctaaaga ccagagcctt 1860cctgtcaccc
ctaaccaagg cataattgaa acaattttag aatttggaac aagcgtcact
1920acatttgata ataattagat cttgcatcat aacaccaaaa gtttataaag
gcatgtggta 1980caatgatcaa aatcatgttt tttcttaaaa aaaaaaaaaa
gactgtaaat tgtgcaacaa 2040agatgcattt acctctgtat caactcagga
aatctcataa gctggtacca ctcaggagaa 2100gtttattctt ccagatgacc
agcagtagac aaatggatac tgagcagagt cttaggtaaa 2160agtcttggga
aatatttggg cattggtctg gccaagtcta caatgtccca atatcaagga
2220caaccaccct agcttcttag tgaagacaat gtacagttat ccattagatc
aagactacac 2280ggtctatgag caataatgtg atttctggac attgcccatg
tataatcctc actgatgatt 2340tcaagctaaa gcaaaccacc ttatacagag
atctagaatc tctttatgtt ctccagagga 2400aggtggaaga aaccatgggc
aggagtagga attgagtgat aaacaattgg gctaatgaag 2460aaaacttctc
ttattgttca gttcatccag attataactt caatgggaca ctttagacca
2520ttagacaatt gacactggat taaacaaatt cacataatgc caaatacaca
atgtatttat 2580agcaacgtat aatttgcaaa gatggacttt aaaagatgct
gtgtaactaa actgaaataa 2640ttcaattact tattatttag aatgttaaag
cttatgatag tcttttctaa ttcttaacac 2700tcatacttga aatctttccg
agtttcccca gaagagaata tgggattttt tttgacattt 2760ttgacccatt
taataatgct cttgtgttta cctagtatat gtagactttg tcttatgtgt
2820caaaagtcct aggaaagtgg ttgatgtttc ttatagcaat taaaaattat
ttttgaactg 2880a 288142592PRThomo sapiens 42Met Ala Ser Glu Ile His
Met Thr Gly Pro Met Cys Leu Ile Glu Asn1 5 10 15Thr Asn Gly Arg Leu
Met Ala Asn Pro Glu Ala Leu Lys Ile Leu Ser20 25 30Ala Ile Thr Gln
Pro Met Val Val Val Ala Ile Val Gly Leu Tyr Arg35 40 45Thr Gly Lys
Ser Tyr Leu Met Asn Lys Leu Ala Gly Lys Lys Lys Gly50 55 60Phe Ser
Leu Gly Ser Thr Val Gln Ser His Thr Lys Gly Ile Trp Met65 70 75
80Trp Cys Val Pro His Pro Lys Lys Pro Gly His Ile Leu Val Leu Leu85
90 95Asp Thr Glu Gly Leu Gly Asp Val Glu Lys Gly Asp Asn Gln Asn
Asp100 105 110Ser Trp Ile Phe Ala Leu Ala Val Leu Leu Ser Ser Thr
Phe Val Tyr115 120 125Asn Ser Ile Gly Thr Ile Asn Gln Gln Ala Met
Asp Gln Leu Tyr Tyr130 135 140Val Thr Glu Leu Thr His Arg Ile Arg
Ser Lys Ser Ser Pro Asp Glu145 150 155 160Asn Glu Asn Glu Val Glu
Asp Ser Ala Asp Phe Val Ser Phe Phe Pro165 170 175Asp Phe Val Trp
Thr Leu Arg Asp Phe Ser Leu Asp Leu Glu Ala Asp180 185 190Gly Gln
Pro Leu Thr Pro Asp Glu Tyr Leu Thr Tyr Ser Leu Lys Leu195 200
205Lys Lys Gly Thr Ser Gln Lys Asp Glu Thr Phe Asn Leu Pro Arg
Leu210 215 220Cys Ile Arg Lys Phe Phe Pro Lys Lys Lys Cys Phe Val
Phe Asp Arg225 230 235 240Pro Val His Arg Arg Lys Leu Ala Gln Leu
Glu Lys Leu Gln Asp Glu245 250 255Glu Leu Asp Pro Glu Phe Val Gln
Gln Val Ala Asp Phe Cys Ser Tyr260 265 270Ile Phe Ser Asn Ser Lys
Thr Lys Thr Leu Ser Gly Gly Ile Gln Val275 280 285Asn Gly Pro Arg
Leu Glu Ser Leu Val Leu Thr Tyr Val Asn Ala Ile290 295 300Ser Ser
Gly Asp Leu Pro Cys Met Glu Asn Ala Val Leu Ala Leu Ala305 310 315
320Gln Ile Glu Asn Ser Ala Ala Val Gln Lys Ala Ile Ala His Tyr
Glu325 330 335Gln Gln Met Gly Gln Lys Val Gln Leu Pro Thr Glu Ser
Leu Gln Glu340 345 350Leu Leu Asp Leu His Arg Asp Ser Glu Arg Glu
Ala Ile Glu Val Phe355 360 365Ile Arg Ser Ser Phe Lys Asp Val Asp
His Leu Phe Gln Lys Glu Leu370 375 380Ala Ala Gln Leu Glu Lys Lys
Arg Asp Asp Phe Cys Lys Gln Asn Gln385 390 395 400Glu Ala Ser Ser
Asp Arg Cys Ser Gly Leu Leu Gln Val Ile Phe Ser405 410 415Pro Leu
Glu Glu Glu Val Lys Ala Gly Ile Tyr Ser Lys Pro Gly Gly420 425
430Tyr Arg Leu Phe Val Gln Lys Leu Gln Asp Leu Lys Lys Lys Tyr
Tyr435 440 445Glu Glu Pro Arg Lys Gly Ile Gln Ala Glu Glu Ile Leu
Gln Thr Tyr450 455 460Leu Lys Ser Lys Glu Ser Met Thr Asp Ala Ile
Leu Gln Thr Asp Gln465 470 475 480Thr Leu Thr Glu Lys Glu Lys Glu
Ile Glu Val Glu Arg Val Lys Ala485 490 495Glu Ser Ala Gln Ala Ser
Ala Lys Met Leu Gln Glu Met Gln Arg Lys500 505 510Asn Glu Gln Met
Met Glu Gln Lys Glu Arg Ser Tyr Gln Glu His Leu515 520 525Lys Gln
Leu Thr Glu Lys Met Glu Asn Asp Arg Val Gln Leu Leu Lys530 535
540Glu Gln Glu Arg Thr Leu Ala Leu Lys Leu Gln Glu Gln Glu Gln
Leu545 550 555 560Leu Lys Glu Gly Phe Gln Lys Glu Ser Arg Ile Met
Lys Asn Glu Ile565 570 575Gln Asp Leu Gln Thr Lys Met Arg Arg Arg
Lys Ala Cys Thr Ile Ser580 585 590434003DNAhomo sapiens
43attaaacctc tcgccgagcc cctccgcaga ctctgcgccg gaaagtttca tttgctgtat
60gccatcctcg agagctgtct aggttaacgt tcgcactctg tgtatataac ctcgacagtc
120ttggcaccta acgtgctgtg cgtagctgct cctttggttg aatccccagg
cccttgttgg 180ggcacaaggt ggcaggatgt ctcagtggta cgaacttcag
cagcttgact caaaattcct 240ggagcaggtt caccagcttt atgatgacag
ttttcccatg gaaatcagac agtacctggc 300acagtggtta gaaaagcaag
actgggagca cgctgccaat gatgtttcat ttgccaccat 360ccgttttcat
gacctcctgt cacagctgga tgatcaatat agtcgctttt ctttggagaa
420taacttcttg ctacagcata acataaggaa aagcaagcgt aatcttcagg
ataattttca 480ggaagaccca atccagatgt ctatgatcat ttacagctgt
ctgaaggaag aaaggaaaat 540tctggaaaac gcccagagat ttaatcaggc
tcagtcgggg aatattcaga gcacagtgat 600gttagacaaa cagaaagagc
ttgacagtaa agtcagaaat gtgaaggaca aggttatgtg 660tatagagcat
gaaatcaaga gcctggaaga tttacaagat gaatatgact tcaaatgcaa
720aaccttgcag aacagagaac acgagaccaa tggtgtggca aagagtgatc
agaaacaaga 780acagctgtta ctcaagaaga tgtatttaat gcttgacaat
aagagaaagg aagtagttca 840caaaataata gagttgctga atgtcactga
acttacccag aatgccctga ttaatgatga 900actagtggag tggaagcgga
gacagcagag cgcctgtatt ggggggccgc ccaatgcttg 960cttggatcag
ctgcagaact ggttcactat agttgcggag agtctgcagc aagttcggca
1020gcagcttaaa aagttggagg aattggaaca gaaatacacc tacgaacatg
accctatcac 1080aaaaaacaaa caagtgttat gggaccgcac cttcagtctt
ttccagcagc tcattcagag 1140ctcgtttgtg gtggaaagac agccctgcat
gccaacgcac cctcagaggc cgctggtctt 1200gaagacaggg gtccagttca
ctgtgaagtt gagactgttg gtgaaattgc aagagctgaa 1260ttataatttg
aaagtcaaag tcttatttga taaagatgtg aatgagagaa atacagtaaa
1320aggatttagg aagttcaaca ttttgggcac gcacacaaaa gtgatgaaca
tggaggagtc 1380caccaatggc agtctggcgg ctgaatttcg gcacctgcaa
ttgaaagaac agaaaaatgc 1440tggcaccaga acgaatgagg gtcctctcat
cgttactgaa gagcttcact cccttagttt 1500tgaaacccaa ttgtgccagc
ctggtttggt aattgacctc gagacgacct ctctgcccgt 1560tgtggtgatc
tccaacgtca gccagctccc gagcggttgg gcctccatcc tttggtacaa
1620catgctggtg gcggaaccca ggaatctgtc cttcttcctg actccaccat
gtgcacgatg 1680ggctcagctt tcagaagtgc tgagttggca gttttcttct
gtcaccaaaa gaggtctcaa 1740tgtggaccag ctgaacatgt tgggagagaa
gcttcttggt cctaacgcca gccccgatgg 1800tctcattccg tggacgaggt
tttgtaagga aaatataaat gataaaaatt ttcccttctg 1860gctttggatt
gaaagcatcc tagaactcat taaaaaacac ctgctccctc tctggaatga
1920tgggtgcatc atgggcttca tcagcaagga gcgagagcgt gccctgttga
aggaccagca 1980gccggggacc ttcctgctgc ggttcagtga gagctcccgg
gaaggggcca tcacattcac 2040atgggtggag cggtcccaga acggaggcga
acctgacttc catgcggttg aaccctacac 2100gaagaaagaa ctttctgctg
ttactttccc tgacatcatt cgcaattaca aagtcatggc 2160tgctgagaat
attcctgaga atcccctgaa gtatctgtat ccaaatattg acaaagacca
2220tgcctttgga aagtattact ccaggccaaa ggaagcacca gagccaatgg
aacttgatgg 2280ccctaaagga actggatata tcaagactga gttgatttct
gtgtctgaag ttcacccttc 2340tagacttcag accacagaca acctgctccc
catgtctcct gaggagtttg acgaggtgtc 2400tcggatagtg ggctctgtag
aattcgacag tatgatgaac acagtataga gcatgaattt 2460ttttcatctt
ctctggcgac agttttcctt ctcatctgtg attccctcct gctactctgt
2520tccttcacat cctgtgtttc tagggaaatg aaagaaaggc cagcaaattc
gctgcaacct 2580gttgatagca agtgaatttt tctctaactc agaaacatca
gttactctga agggcatcat 2640gcatcttact gaaggtaaaa ttgaaaggca
ttctctgaag agtgggtttc acaagtgaaa 2700aacatccaga tacacccaaa
gtatcaggac gagaatgagg gtcctttggg aaaggagaag 2760ttaagcaaca
tctagcaaat gttatgcata aagtcagtgc ccaactgtta taggttgttg
2820gataaatcag tggttattta gggaactgct tgacgtagga acggtaaatt
tctgtgggag 2880aattcttaca tgttttcttt gctttaagtg taactggcag
ttttccattg gtttacctgt 2940gaaatagttc aaagccaagt ttatatacaa
ttatatcagt cctctttcaa aggtagccat 3000catggatctg gtagggggaa
aatgtgtatt ttattacatc tttcacattg gctatttaaa 3060gacaaagaca
aattctgttt cttgagaaga gaatattagc tttactgttt gttatggctt
3120aatgacacta gctaatatca atagaaggat gtacatttcc aaattcacaa
gttgtgtttg 3180atatccaaag ctgaatacat tctgctttca tcttggtcac
atacaattat ttttacagtt 3240ctcccaaggg agttaggcta ttcacaacca
ctcattcaaa agttgaaatt aaccatagat 3300gtagataaac tcagaaattt
aattcatgtt tcttaaatgg gctactttgt cctttttgtt 3360attagggtgg
tatttagtct attagccaca aaattgggaa aggagtagaa aaagcagtaa
3420ctgacaactt gaataataca ccagagataa tatgagaatc agatcatttc
aaaactcatt 3480tcctatgtaa ctgcattgag aactgcatat gtttcgctga
tatatgtgtt tttcacattt 3540gcgaatggtt ccattctctc tcctgtactt
tttccagaca cttttttgag tggatgatgt 3600ttcgtgaagt atactgtatt
tttacctttt tccttcctta tcactgacac aaaaagtaga 3660ttaagagatg
ggtttgacaa ggttcttccc ttttacatac tgctgtctat gtggctgtat
3720cttgtttttc cactactgct accacaacta tattatcatg caaatgctgt
attcttcttt 3780ggtggagata aagatttctt gagttttgtt ttaaaattaa
agctaaagta tctgtattgc 3840attaaatata atatcgacac agtgctttcc
gtggcactgc atacaatctg aggcctcctc 3900tctcagtttt tatatagatg
gcgagaacct aagtttcagt tgattttaca attgaaatga 3960ctaaaaaaca
aagaagacaa cattaaaaac aatattgttt cta 400344750PRThomo sapiens 44Met
Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu1 5 10
15Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln20
25 30Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala
Asn35 40 45Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser
Gln Leu50 55 60Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe
Leu Leu Gln65 70 75 80His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln
Asp Asn Phe Gln Glu85 90 95Asp Pro Ile Gln Met Ser Met Ile Ile Tyr
Ser Cys Leu Lys Glu Glu100 105 110Arg Lys Ile Leu Glu Asn Ala Gln
Arg Phe Asn Gln Ala Gln Ser Gly115 120 125Asn Ile Gln Ser Thr Val
Met Leu Asp Lys Gln Lys Glu Leu Asp Ser130 135 140Lys Val Arg Asn
Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile145 150 155 160Lys
Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr165 170
175Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp
Gln180 185 190Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met
Leu Asp Asn195 200 205Lys Arg Lys Glu Val Val His Lys Ile Ile Glu
Leu Leu Asn Val Thr210 215 220Glu Leu Thr Gln Asn Ala Leu Ile Asn
Asp Glu Leu Val Glu Trp Lys225 230 235 240Arg Arg Gln Gln Ser Ala
Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu245 250 255Asp Gln Leu Gln
Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln260 265 270Val Arg
Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr275 280
285Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp
Arg290 295 300Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe
Val Val Glu305 310 315 320Arg Gln Pro Cys Met Pro Thr His Pro Gln
Arg Pro Leu Val Leu Lys325 330 335Thr Gly Val Gln Phe Thr Val Lys
Leu Arg Leu Leu Val Lys Leu Gln340 345 350Glu Leu Asn Tyr Asn Leu
Lys Val Lys Val Leu Phe Asp Lys Asp Val355 360 365Asn Glu Arg Asn
Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly370 375 380Thr His
Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu385 390 395
400Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala
Gly405 410 415Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu
Leu His Ser420 425 430Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly
Leu Val Ile Asp Leu435 440 445Glu Thr Thr Ser Leu Pro Val Val Val
Ile Ser Asn Val Ser Gln Leu450 455 460Pro Ser Gly Trp Ala Ser Ile
Leu Trp Tyr Asn Met Leu Val Ala Glu465 470 475 480Pro Arg Asn Leu
Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala485 490 495Gln Leu
Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg500 505
510Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu
Gly515 520 525Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg
Phe Cys Lys530 535 540Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp
Leu Trp Ile Glu Ser545 550 555 560Ile Leu Glu Leu Ile Lys Lys His
Leu Leu Pro Leu Trp Asn Asp Gly565 570 575Cys Ile Met Gly Phe Ile
Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys580 585 590Asp Gln Gln Pro
Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg595 600 605Glu Gly
Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly610 615
620Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu
Ser625 630 635 640Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys
Val Met Ala Ala645 650 655Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr
Leu Tyr Pro Asn Ile Asp660 665 670Lys Asp His Ala Phe Gly Lys Tyr
Tyr Ser Arg Pro Lys Glu Ala Pro675 680 685Glu Pro Met Glu Leu Asp
Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr690 695 700Glu Leu Ile Ser
Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr705 710 715 720Asp
Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg725 730
735Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val740 745
750452303DNAhomo sapiens 45cccggcgtcc cgtcgagccc agccccgccg
ggggcgctcc tcgccgcccg cacgccctcc 60ccagccatgt cgtccatcct gcctttcact
cccccgatcg tgaagcgcct gctgggctgg 120aagaagggcg agcagaacgg
gcaggaggag aaatggtgcg agaaggcggt caagagcctg 180gtcaagaaac
tcaagaagac ggggcagctg gacgagctgg agaaggccat caccacgcag
240aacgtcaaca ccaagtgcat caccatcccc aggtccctgg atggccggtt
gcaggtgtcc 300catcggaagg ggctccctca tgtcatctac
tgccgcctgt ggcgatggcc agacctgcac 360agccaccacg agctgcgggc
catggagctg tgtgagttcg ccttcaatat gaagaaggac 420gaggtctgcg
tgaatcccta ccactaccag agagtagaga caccagttct acctcctgtg
480ttggtgccac gccacacaga gatcccggcc gagttccccc cactggacga
ctacagccat 540tccatccccg aaaacactaa cttccccgca ggcatcgagc
cccagagcaa tattccagag 600accccacccc ctggctacct gagtgaagat
ggagaaacca gtgaccacca gatgaaccac 660agcatggacg caggttctcc
aaacctatcc ccgaatccga tgtccccagc acataataac 720ttggacctgc
agccagttac ctactgcgag ccggccttct ggtgctccat ctcctactac
780gagctgaacc agcgcgtcgg ggagacattc cacgcctcgc agccatccat
gactgtggat 840ggcttcaccg acccctccaa ttcggagcgc ttctgcctag
ggctgctctc caatgtcaac 900aggaatgcag cagtggagct gacacggaga
cacatcggaa gaggcgtgcg gctctactac 960atcggagggg aggtcttcgc
agagtgcctc agtgacagcg ctatttttgt ccagtctccc 1020aactgtaacc
agcgctatgg ctggcacccg gccaccgtct gcaagatccc accaggatgc
1080aacctgaaga tcttcaacaa ccaggagttc gctgccctcc tggcccagtc
ggtcaaccag 1140ggctttgagg ctgtctacca gttgacccga atgtgcacca
tccgcatgag cttcgtcaaa 1200ggctggggag cggagtacag gagacagact
gtgaccagta ccccctgctg gattgagctg 1260cacctgaatg ggcctttgca
gtggcttgac aaggtcctca cccagatggg ctccccaagc 1320atccgctgtt
ccagtgtgtc ttagagacat caagtatggt aggggagggc aggcttgggg
1380aaaatggcca tacaggaggt ggagaaaatt ggaactctac tcaacccatt
gttgtcaagg 1440aagaagaaat ctttctccct caactgaagg ggtgcaccca
cctgttttct gaaacacacg 1500agcaaaccca gaggtggatg ttatgaacag
ctgtgtctgc caaacacatt taccctttgg 1560ccccactttg aagggcaaga
aatggcgtct gctctggtgg cttaagtgag cagaacaggt 1620agtattacac
caccggcacc ctccccccag actctttttt tgagtgacag ctttctggga
1680tgtcacagtc caaccagaaa cgcccctctg tctaggactg cagtgtggag
ttcaccttgg 1740aagggcgttc taggtaggaa gagcccgcac gatgcagacc
tcatgcccag ctctctgacg 1800cttgtgacag tgcctcttcc agtgaacatt
cccagcccag ccccgccccg ttgtgagctg 1860gatagacttg ggatggggag
ggagggagtt ttgtctgtct ccctcccctc tcagaacata 1920ctgattggga
ggtgcgtgtt cagcagaacc tgcacacagg acagcgggaa aaatcgatga
1980gcgccacctc tttaaaaact cacttacgtt gtcctttttc actttgaaaa
gttggaagga 2040ctgctgaggc ccagtgcata tgcaatgtat agtgtctatt
atcacattaa tctcaaagag 2100attcgaatga cggtaagtgt tctcatgaag
caggaggccc ttgtcgtggg atggcatttg 2160gtctcaggca gcaccacact
gggtgcgtct ccagtcatct gtaagagctt gctccagatt 2220ctgatgcata
cggctatatt ggtttatgta gtcagttgca ttcattaaat caactttatc
2280atatgctcaa aaaaaaaaaa aag 230346425PRThomo sapiens 46Met Ser
Ser Ile Leu Pro Phe Thr Pro Pro Ile Val Lys Arg Leu Leu1 5 10 15Gly
Trp Lys Lys Gly Glu Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu20 25
30Lys Ala Val Lys Ser Leu Val Lys Lys Leu Lys Lys Thr Gly Gln Leu35
40 45Asp Glu Leu Glu Lys Ala Ile Thr Thr Gln Asn Val Asn Thr Lys
Cys50 55 60Ile Thr Ile Pro Arg Ser Leu Asp Gly Arg Leu Gln Val Ser
His Arg65 70 75 80Lys Gly Leu Pro His Val Ile Tyr Cys Arg Leu Trp
Arg Trp Pro Asp85 90 95Leu His Ser His His Glu Leu Arg Ala Met Glu
Leu Cys Glu Phe Ala100 105 110Phe Asn Met Lys Lys Asp Glu Val Cys
Val Asn Pro Tyr His Tyr Gln115 120 125Arg Val Glu Thr Pro Val Leu
Pro Pro Val Leu Val Pro Arg His Thr130 135 140Glu Ile Pro Ala Glu
Phe Pro Pro Leu Asp Asp Tyr Ser His Ser Ile145 150 155 160Pro Glu
Asn Thr Asn Phe Pro Ala Gly Ile Glu Pro Gln Ser Asn Ile165 170
175Pro Glu Thr Pro Pro Pro Gly Tyr Leu Ser Glu Asp Gly Glu Thr
Ser180 185 190Asp His Gln Met Asn His Ser Met Asp Ala Gly Ser Pro
Asn Leu Ser195 200 205Pro Asn Pro Met Ser Pro Ala His Asn Asn Leu
Asp Leu Gln Pro Val210 215 220Thr Tyr Cys Glu Pro Ala Phe Trp Cys
Ser Ile Ser Tyr Tyr Glu Leu225 230 235 240Asn Gln Arg Val Gly Glu
Thr Phe His Ala Ser Gln Pro Ser Met Thr245 250 255Val Asp Gly Phe
Thr Asp Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly260 265 270Leu Leu
Ser Asn Val Asn Arg Asn Ala Ala Val Glu Leu Thr Arg Arg275 280
285His Ile Gly Arg Gly Val Arg Leu Tyr Tyr Ile Gly Gly Glu Val
Phe290 295 300Ala Glu Cys Leu Ser Asp Ser Ala Ile Phe Val Gln Ser
Pro Asn Cys305 310 315 320Asn Gln Arg Tyr Gly Trp His Pro Ala Thr
Val Cys Lys Ile Pro Pro325 330 335Gly Cys Asn Leu Lys Ile Phe Asn
Asn Gln Glu Phe Ala Ala Leu Leu340 345 350Ala Gln Ser Val Asn Gln
Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg355 360 365Met Cys Thr Ile
Arg Met Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr370 375 380Arg Arg
Gln Thr Val Thr Ser Thr Pro Cys Trp Ile Glu Leu His Leu385 390 395
400Asn Gly Pro Leu Gln Trp Leu Asp Lys Val Leu Thr Gln Met Gly
Ser405 410 415Pro Ser Ile Arg Cys Ser Ser Val Ser420
425474208DNAhomo sapiens 47tctttaagat ttgtagctac taagaaagaa
aggagctttt tttccttggg ccttcaaact 60gaaagaaccg catgagcctg acggcgcatg
gtcttaacat caggctgtgc aggaagaagc 120tatctgcaga tggatgccag
cacacacaag gaagcagagc tctggcaaca ttgagtcaaa 180gcaaggacac
aacatcagag ggacggcaga gaatccttgt gtgtagtctt tggtggcagt
240ttgaaaattg caaggaggga ctttaagact acttctgatt tgcaaagatg
gtctgtgctc 300cgagcaggct aaagtgactg gacgagacgc actgttggag
aaataaaaat gacttcccat 360tatgtgattg ccatctttgc cctgatgagc
ttctgtttag ccactgcagg tccagagcct 420ggtgcactgt gtgaactgtc
acctgtcagt gcctcccatc ctgtccaggc cttgatggag 480agcttcactg
ttttgtcagg ctgtgccagc agaggcacaa ctgggctgcc acaggaggtg
540catgtcctga atctcgcact gcgccagggg cctggccagc tacagagaga
ggtcacactt 600cacctgaatc ccatctcctc agtccacatc caccacaagt
ctgttgtgtt cctgctcaac 660tccccacacc ccctggtgtg gcatctgaag
acagagagac ttgccactgg ggtctccaga 720ctgtttttgg tgtctgaggg
ttctgtggtc cagttttcat cagcaaactt ctccttgaca 780gcagaaacag
aagaaaggaa cttcccccat ggaaatgaac atctgttaaa ttgggcccga
840aaagagtatg gagcagttac ttcattcacc gaactcaaga tagcaagaaa
catttatatt 900aaagtggggg aagatcaagt gttccctcca aagtgcaaca
tagggaagaa ttttctctca 960ctcaattacc ttgctgagta ccttcaaccc
aaagcagcag aagggtgtgt gatgtccagc 1020cagccccaga atgaggaagt
acacatcatc gagctaatca cccccaactc taacccctac 1080agtgctttcc
aggtggatat aacaattgat ataagacctt ctcaagagga tcttgaagtg
1140gtcaaaaatc tcatcctgat cttgaagtgc aaaaagtctg tcaactgggt
gatcaaatct 1200tttgatgtta agggaagcct gaaaattatt gctcctaaca
gtattggctt tggaaaagag 1260agtgaaagat ctatgacaat gaccaaatca
ataagagatg acattccttc aacccaaggg 1320aatctggtga agtgggcttt
ggacaatggc tatagtccaa taacttcata cacaatggct 1380cctgtggcaa
tagtatttca tcttcggctt gaaaataatg aggagatggg agatgaggaa
1440gtccacacta ttcctcctga gctacggatc ctgctggacc ctggtgccct
gcctgccctg 1500cagaacccgc ccatccgggg aggggaaggc caaaatggag
gccttccgtt tcctttccca 1560gatatttcca ggagagtctg gaatgaagag
ggagaagatg ggctccctcg gccaaaggac 1620cctgtcattc ccagcataca
actgtttcct ggtctcagag agccagaaga ggtgcaaggg 1680agcgtggata
ttgccctgtc tgtcaaatgt gacaatgaga agatgatcgt ggctgtagaa
1740aaagattctt ttcaggccag tggctactcg gggatggacg tcaccctgtt
ggatcctacc 1800tgcaaggcca agatgaatgg cacacacttt gttttggagt
ctcctctgaa tggctgcggt 1860actcggcccc ggtggtcagc ccttgatggt
gtggtctact ataactccat tgtgatacag 1920gttccagccc ttggggacag
tagtggttgg ccagatggtt atgaagatct ggagtcaggt 1980gataatggat
ttccgggaga tatggatgaa ggagatgctt ccctgttcac ccgacctgaa
2040atcgtggtgt ttaattgcag ccttcagcag gtgaggaacc ccagcagctt
ccaggaacag 2100ccccacggaa acatcacctt caacatggag ctatacaaca
ctgacctctt tttggtgccc 2160tcccagggcg tcttctctgt gccagagaat
ggacacgttt atgttgaggt atctgttact 2220aaggctgaac aagaactggg
atttgccatc caaacgtgct ttatctctcc atattcgaac 2280cctgatagga
tgtctcatta caccattatt gagaatattt gtcctaaaga tgaatctgtg
2340aaattctaca gtcccaagag agtgcacttc cctatcccgc aagctgacat
ggataagaag 2400cgattcagct ttgtcttcaa gcctgtcttc aacacctcac
tgctctttct acagtgtgag 2460ctgacgctgt gtacgaagat ggagaagcac
ccccagaagt tgcctaagtg tgtgcctcct 2520gacgaagcct gcacctcgct
ggacgcctcg ataatctggg ccatgatgca gaataagaag 2580acgttcacca
agccccttgc tgtgatccac catgaagcag aatctaaaga aaaaggtcca
2640agcatgaagg aaccaaatcc aatttctcca ccaattttcc atggtctgga
caccctaacc 2700gtgatgggca ttgcgtttgc agcctttgtg atcggagcac
tcctgacggg ggccttgtgg 2760tacatctatt ctcacacagg ggagacagca
ggaaggcagc aagtccccac ctccccgcca 2820gcctcggaaa acagcagtgc
tgcccacagc atcggcagca cgcagagcac gccttgctcc 2880agcagcagca
cggcctagcc caacccaggc ccaacccggc ccaacccagc ccagcccagc
2940tcagctcagc tactccaagg gcaggaccaa tggctgagcc tcgtgtccag
actcagaggg 3000ctggattttg gttcccttgt aaagacagag tgaatttcag
tataaagatc acccgttgta 3060ttcaccccac acccagggct agtataaaca
tgaccctggg cttctgtacc acactagaat 3120tcatgtgaga aagctaaaat
ggtggtcttc tccaccagcc cctcacaggc ttgggggttt 3180tctatgtgaa
acacatgcca gtttttaaaa tgctgctttg tccaggtgag aacatccata
3240atttggggcc ctgagtttta cccagactca aggagttggt aaagggttaa
tagccagata 3300gtagaaccag tgaggagatg cggccaaaga ttctttatat
ctgaaccaag atgtaaaaca 3360agaaatgctt tgaggctttc taagcgatcc
tcctgtctaa tttgcacctt tgtctggatg 3420cactcttctg accttgctgc
cacaacctgt ggggtctgat gtgtcccaag atgggtgctg 3480ccctcaggga
ctgcaccctg acaagtgtta aggcaacatt ccttgcttgt gccctgggcc
3540aaaaccaatg ctgatgacct tatcagcttc ctgtttcttc ccatactgca
tacaccactg 3600caaaatgtct taatgcaaat tttgtatttc ttacaggcct
acagaaattg aaaatgacca 3660aaatcaggaa ccacagattt gtgcccattc
ctaatatttt gttctgcaaa ttaatgtata 3720atttgaggtg aaattcagtt
ataaagtcaa ggacgaattt gcacagtgat atatttctat 3780gtgtatgcaa
gtacaagtat ataatatgtc acctggcaca ttcattttct cagttgaaga
3840agagaaaatt tgaaaatgtc cttatgcttt tagagttgca acttaagtat
atttggtagg 3900gtgagtgttt ccactcaaaa tatgtcaact taaaaaaaaa
taggcccttt cataaaaacc 3960aaactgtagc aagatgcaaa tgcatggcaa
atctgtcggt ctccagttgg ttatctgaat 4020agtgtcacca attccaccaa
gacagtgctg agattggaaa gggcactcat ttggattgcc 4080ttacttctct
tgccttaaat atatcccata tatttaatat gtcaaaaagg gcttgaggtg
4140aatttcatta aatggaataa tatgatgcca ctttgcagct aaaataagct
cagtgatacc 4200tccttgtt 420848849PRThomo sapiens 48Met Thr Ser His
Tyr Val Ile Ala Ile Phe Ala Leu Met Ser Phe Cys1 5 10 15Leu Ala Thr
Ala Gly Pro Glu Pro Gly Ala Leu Cys Glu Leu Ser Pro20 25 30Val Ser
Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe Thr Val35 40 45Leu
Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Gln Glu Val50 55
60His Val Leu Asn Leu Ala Leu Arg Gln Gly Pro Gly Gln Leu Gln Arg65
70 75 80Glu Val Thr Leu His Leu Asn Pro Ile Ser Ser Val His Ile His
His85 90 95Lys Ser Val Val Phe Leu Leu Asn Ser Pro His Pro Leu Val
Trp His100 105 110Leu Lys Thr Glu Arg Leu Ala Thr Gly Val Ser Arg
Leu Phe Leu Val115 120 125Ser Glu Gly Ser Val Val Gln Phe Ser Ser
Ala Asn Phe Ser Leu Thr130 135 140Ala Glu Thr Glu Glu Arg Asn Phe
Pro His Gly Asn Glu His Leu Leu145 150 155 160Asn Trp Ala Arg Lys
Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu Leu165 170 175Lys Ile Ala
Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp Gln Val Phe180 185 190Pro
Pro Lys Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr Leu195 200
205Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val Met Ser
Ser210 215 220Gln Pro Gln Asn Glu Glu Val His Ile Ile Glu Leu Ile
Thr Pro Asn225 230 235 240Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp
Ile Thr Ile Asp Ile Arg245 250 255Pro Ser Gln Glu Asp Leu Glu Val
Val Lys Asn Leu Ile Leu Ile Leu260 265 270Lys Cys Lys Lys Ser Val
Asn Trp Val Ile Lys Ser Phe Asp Val Lys275 280 285Gly Ser Leu Lys
Ile Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys Glu290 295 300Ser Glu
Arg Ser Met Thr Met Thr Lys Ser Ile Arg Asp Asp Ile Pro305 310 315
320Ser Thr Gln Gly Asn Leu Val Lys Trp Ala Leu Asp Asn Gly Tyr
Ser325 330 335Pro Ile Thr Ser Tyr Thr Met Ala Pro Val Ala Ile Val
Phe His Leu340 345 350Arg Leu Glu Asn Asn Glu Glu Met Gly Asp Glu
Glu Val His Thr Ile355 360 365Pro Pro Glu Leu Arg Ile Leu Leu Asp
Pro Gly Ala Leu Pro Ala Leu370 375 380Gln Asn Pro Pro Ile Arg Gly
Gly Glu Gly Gln Asn Gly Gly Leu Pro385 390 395 400Phe Pro Phe Pro
Asp Ile Ser Arg Arg Val Trp Asn Glu Glu Gly Glu405 410 415Asp Gly
Leu Pro Arg Pro Lys Asp Pro Val Ile Pro Ser Ile Gln Leu420 425
430Phe Pro Gly Leu Arg Glu Pro Glu Glu Val Gln Gly Ser Val Asp
Ile435 440 445Ala Leu Ser Val Lys Cys Asp Asn Glu Lys Met Ile Val
Ala Val Glu450 455 460Lys Asp Ser Phe Gln Ala Ser Gly Tyr Ser Gly
Met Asp Val Thr Leu465 470 475 480Leu Asp Pro Thr Cys Lys Ala Lys
Met Asn Gly Thr His Phe Val Leu485 490 495Glu Ser Pro Leu Asn Gly
Cys Gly Thr Arg Pro Arg Trp Ser Ala Leu500 505 510Asp Gly Val Val
Tyr Tyr Asn Ser Ile Val Ile Gln Val Pro Ala Leu515 520 525Gly Asp
Ser Ser Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu Ser Gly530 535
540Asp Asn Gly Phe Pro Gly Asp Met Asp Glu Gly Asp Ala Ser Leu
Phe545 550 555 560Thr Arg Pro Glu Ile Val Val Phe Asn Cys Ser Leu
Gln Gln Val Arg565 570 575Asn Pro Ser Ser Phe Gln Glu Gln Pro His
Gly Asn Ile Thr Phe Asn580 585 590Met Glu Leu Tyr Asn Thr Asp Leu
Phe Leu Val Pro Ser Gln Gly Val595 600 605Phe Ser Val Pro Glu Asn
Gly His Val Tyr Val Glu Val Ser Val Thr610 615 620Lys Ala Glu Gln
Glu Leu Gly Phe Ala Ile Gln Thr Cys Phe Ile Ser625 630 635 640Pro
Tyr Ser Asn Pro Asp Arg Met Ser His Tyr Thr Ile Ile Glu Asn645 650
655Ile Cys Pro Lys Asp Glu Ser Val Lys Phe Tyr Ser Pro Lys Arg
Val660 665 670His Phe Pro Ile Pro Gln Ala Asp Met Asp Lys Lys Arg
Phe Ser Phe675 680 685Val Phe Lys Pro Val Phe Asn Thr Ser Leu Leu
Phe Leu Gln Cys Glu690 695 700Leu Thr Leu Cys Thr Lys Met Glu Lys
His Pro Gln Lys Leu Pro Lys705 710 715 720Cys Val Pro Pro Asp Glu
Ala Cys Thr Ser Leu Asp Ala Ser Ile Ile725 730 735Trp Ala Met Met
Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu Ala Val740 745 750Ile His
His Glu Ala Glu Ser Lys Glu Lys Gly Pro Ser Met Lys Glu755 760
765Pro Asn Pro Ile Ser Pro Pro Ile Phe His Gly Leu Asp Thr Leu
Thr770 775 780Val Met Gly Ile Ala Phe Ala Ala Phe Val Ile Gly Ala
Leu Leu Thr785 790 795 800Gly Ala Leu Trp Tyr Ile Tyr Ser His Thr
Gly Glu Thr Ala Gly Arg805 810 815Gln Gln Val Pro Thr Ser Pro Pro
Ala Ser Glu Asn Ser Ser Ala Ala820 825 830His Ser Ile Gly Ser Thr
Gln Ser Thr Pro Cys Ser Ser Ser Ser Thr835 840 845Ala492181DNAhomo
sapiens 49ggaaagcatc caacggagtg gaagcagcat gaaggaagag ccgctgggca
gcggcatgaa 60cgcggtgcgg acgtggatgc agggcgccgg ggtgctggac gccaacacgg
cggcgcagag 120cggggtgggt ctggcccggg ctcactttga gaagcagccg
ccttccaatc tgcggaaatc 180caacttcttc cacttcgtcc tggccctcta
cgacagacag ggccagcccg tggagatcga 240gaggacagcg tttgtggggt
tcgtggagaa ggaaaaagaa gccaacagcg aaaagaccaa 300taacggaatt
cactaccgga ttcagcttct ctacagcaat gggataagga cggagcagga
360tttctacgtg cgcctcattg actccatgac aaaacaagcc atagtgtatg
aaggccaaga 420caagagccca gaaatgtgcc gagtcttgct cacacatgag
atcatgtgca gccgctgttg 480tgacaagaaa agctgtggca accgaaatga
gactccctca gatccagtga taattgacag 540attcttcttg aaatttttcc
tcaaatgtaa ccaaaattgc ctaaagaatg cgggaaaccc 600acgtgacatg
cggagattcc aggtcgtggt gtctacgaca gtcaatgtgg atggccatgt
660cctggcagct cctgataaca tgtttgtcca taataattcc aagcatgggc
ggagggctcg 720gaggcttgac ccctcggaag gtacgccctc ttatctggaa
catgctactc cctgtatcaa 780agccatcagc ccgagtgaag gatggacgac
cggaggtgcg actgtcatca tcatagggga 840caatttcttt gatgggttac
aggtcatatt cggtaccatg ctggtctgga gtgagttgac 900aggtcctcat
tccatccgtg tgcagacccc tcctcggcac atccctggtg ttgtggaagt
960cacactgtcc tacaaatcta agcagttctg caaaggaaca ccaggcagat
tcatttatac 1020agcgcgcaac gaacccacca tcgattatgg tttccagagg
ttacagaagg tcattcctcg 1080gcaccctggt gaccctgagc gtttgccaaa
ggaagtaata ctgaaaaggg ctgcggatct 1140ggtagaagca ctgtatggga
tgccacacaa caaccaggaa atcattctga agagagcggc 1200cgacattgcc
gaggccctgt acagtgtccc ccgcaaccac aaccaactcc cggcccttgc
1260taacacctcg gtccacgcag ggatgatggg cgtgaattcg ttcagtggac
aactggccgt 1320gaatgtctcc gaggcatcac aagccaccaa tcagggtttc
acccgcaact caagcagcgt 1380atcaccacac gggtacgtgc cgagcaccac
tccccagcag accaactata actccgtcac 1440cacgagcatg aacggatacg
gctctgccgc aatgtccaat ttgggtggct
cccccacctt 1500cctcaacggc tcagctgcca actcccccta tgccatagtg
ccatccagcc ccaccatggc 1560ctcctccaca agcctcccct ccaactgcag
cagctcctcg ggcatcttct ccttctcacc 1620agccaacatg gtctcagccg
tgaaacagaa gagtgctttc gcaccagtcg tcagacccca 1680gacctcccca
cctcccacct gcaccagcac caacgggaac agcctgcaag cgatatctgg
1740catgattgtt cctcctatgt gaaagaattg ccttgaagaa ttgtattaat
gaagaggttg 1800gattctgcta cagagagtaa tctgatacaa gtcccagagt
ggaactttta actcaggcct 1860ttataagagg aatcacacaa taactgcaga
tttttaaaca aaatcaccga ccttgcaaat 1920actgaaattg gaagaggaat
ctgaaagtgc agggtgttgg ttaaagttgt acctcccaag 1980tattttgggg
atatatttat tctgtattga caaaagcaaa tccacttttt ctttttcttt
2040ttttttttta agcttaattc tgcaatcatt tgacttttat ataccgtaat
gctctataca 2100agggacacta taaataagac tccatgtttt aatttatgtt
tttaaagctg tgtaaaggaa 2160gaatgaagtg gtgatattta c 218150586PRThomo
sapiens 50Glu Ser Ile Gln Arg Ser Gly Ser Ser Met Lys Glu Glu Pro
Leu Gly1 5 10 15Ser Gly Met Asn Ala Val Arg Thr Trp Met Gln Gly Ala
Gly Val Leu20 25 30Asp Ala Asn Thr Ala Ala Gln Ser Gly Val Gly Leu
Ala Arg Ala His35 40 45Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys
Ser Asn Phe Phe His50 55 60Phe Val Leu Ala Leu Tyr Asp Arg Gln Gly
Gln Pro Val Glu Ile Glu65 70 75 80Arg Thr Ala Phe Val Gly Phe Val
Glu Lys Glu Lys Glu Ala Asn Ser85 90 95Glu Lys Thr Asn Asn Gly Ile
His Tyr Arg Ile Gln Leu Leu Tyr Ser100 105 110Asn Gly Ile Arg Thr
Glu Gln Asp Phe Tyr Val Arg Leu Ile Asp Ser115 120 125Met Thr Lys
Gln Ala Ile Val Tyr Glu Gly Gln Asp Lys Ser Pro Glu130 135 140Met
Cys Arg Val Leu Leu Thr His Glu Ile Met Cys Ser Arg Cys Cys145 150
155 160Asp Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr Pro Ser Asp Pro
Val165 170 175Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu Lys Cys
Asn Gln Asn180 185 190Cys Leu Lys Asn Ala Gly Asn Pro Arg Asp Met
Arg Arg Phe Gln Val195 200 205Val Val Ser Thr Thr Val Asn Val Asp
Gly His Val Leu Ala Ala Pro210 215 220Asp Asn Met Phe Val His Asn
Asn Ser Lys His Gly Arg Arg Ala Arg225 230 235 240Arg Leu Asp Pro
Ser Glu Gly Thr Pro Ser Tyr Leu Glu His Ala Thr245 250 255Pro Cys
Ile Lys Ala Ile Ser Pro Ser Glu Gly Trp Thr Thr Gly Gly260 265
270Ala Thr Val Ile Ile Ile Gly Asp Asn Phe Phe Asp Gly Leu Gln
Val275 280 285Ile Phe Gly Thr Met Leu Val Trp Ser Glu Leu Thr Gly
Pro His Ser290 295 300Ile Arg Val Gln Thr Pro Pro Arg His Ile Pro
Gly Val Val Glu Val305 310 315 320Thr Leu Ser Tyr Lys Ser Lys Gln
Phe Cys Lys Gly Thr Pro Gly Arg325 330 335Phe Ile Tyr Thr Ala Arg
Asn Glu Pro Thr Ile Asp Tyr Gly Phe Gln340 345 350Arg Leu Gln Lys
Val Ile Pro Arg His Pro Gly Asp Pro Glu Arg Leu355 360 365Pro Lys
Glu Val Ile Leu Lys Arg Ala Ala Asp Leu Val Glu Ala Leu370 375
380Tyr Gly Met Pro His Asn Asn Gln Glu Ile Ile Leu Lys Arg Ala
Ala385 390 395 400Asp Ile Ala Glu Ala Leu Tyr Ser Val Pro Arg Asn
His Asn Gln Leu405 410 415Pro Ala Leu Ala Asn Thr Ser Val His Ala
Gly Met Met Gly Val Asn420 425 430Ser Phe Ser Gly Gln Leu Ala Val
Asn Val Ser Glu Ala Ser Gln Ala435 440 445Thr Asn Gln Gly Phe Thr
Arg Asn Ser Ser Ser Val Ser Pro His Gly450 455 460Tyr Val Pro Ser
Thr Thr Pro Gln Gln Thr Asn Tyr Asn Ser Val Thr465 470 475 480Thr
Ser Met Asn Gly Tyr Gly Ser Ala Ala Met Ser Asn Leu Gly Gly485 490
495Ser Pro Thr Phe Leu Asn Gly Ser Ala Ala Asn Ser Pro Tyr Ala
Ile500 505 510Val Pro Ser Ser Pro Thr Met Ala Ser Ser Thr Ser Leu
Pro Ser Asn515 520 525Cys Ser Ser Ser Ser Gly Ile Phe Ser Phe Ser
Pro Ala Asn Met Val530 535 540Ser Ala Val Lys Gln Lys Ser Ala Phe
Ala Pro Val Val Arg Pro Gln545 550 555 560Thr Ser Pro Pro Pro Thr
Cys Thr Ser Thr Asn Gly Asn Ser Leu Gln565 570 575Ala Ile Ser Gly
Met Ile Val Pro Pro Met580 585511129DNAhomo sapiens 51gtggcccccg
cggtgcggag tatggggcgc tgatggccat ggagggctac tggcgcttcc 60tggcgctgct
ggggtcggca ctgctcgtcg gcttcctgtc ggtgatcttc gccctcgtct
120gggtcctcca ctaccgagag gggcttggct gggatgggag cgcactagag
tttaactggc 180acccagtgct catggtcacc ggcttcgtct tcatccaggg
catcgccatc atcgtctaca 240gactgccgtg gacctggaaa tgcagcaagc
tcctgatgaa atccatccat gcagggttaa 300atgcagttgc tgccattctt
gcaattatct ctgtggtggc cgtgtttgag aaccacaatg 360ttaacaatat
agccaatatg tacagtctgc acagctgggt tggactgata gctgtcatat
420gctatttgtt acagcttctt tcaggttttt cagtctttct gcttccatgg
gctccgcttt 480ctctccgagc atttctcatg cccatacatg tttattctgg
aattgtcatc tttggaacag 540tgattgcaac agcacttatg ggattgacag
agaaactgat tttttccctg agagatcctg 600catacagtac attcccgcca
gaaggtgttt tcgtaaatac gcttggcctt ctgatcctgg 660tgttcggggc
cctcattttt tggatagtca ccagaccgca atggaaacgt cctaaggagc
720caaattctac cattcttcat ccaaatggag gcactgaaca gggagcaaga
ggttccatgc 780cagcctactc tggcaacaac atggacaaat cagattcaga
gttaaacagt gaagtagcag 840caaggaaaag aaacttagct ctggatgagg
ctgggcagag atctaccatg taaaatgttg 900tagagataga gccatataac
gtcacgtttc aaaactagct ctacagtttt gcttctccta 960ttagccatat
gataattggg ctatgtagta tcaatattta ctttaatcac aaaggatggt
1020ttcttgaaat aatttgtatt gattgaggcc tatgaactga cctgaattgg
aaaggatgtg 1080attaatataa ataatagcag atataaatta aaaaaaaaaa
aaaagaaaa 112952286PRThomo sapiens 52Met Ala Met Glu Gly Tyr Trp
Arg Phe Leu Ala Leu Leu Gly Ser Ala1 5 10 15Leu Leu Val Gly Phe Leu
Ser Val Ile Phe Ala Leu Val Trp Val Leu20 25 30His Tyr Arg Glu Gly
Leu Gly Trp Asp Gly Ser Ala Leu Glu Phe Asn35 40 45Trp His Pro Val
Leu Met Val Thr Gly Phe Val Phe Ile Gln Gly Ile50 55 60Ala Ile Ile
Val Tyr Arg Leu Pro Trp Thr Trp Lys Cys Ser Lys Leu65 70 75 80Leu
Met Lys Ser Ile His Ala Gly Leu Asn Ala Val Ala Ala Ile Leu85 90
95Ala Ile Ile Ser Val Val Ala Val Phe Glu Asn His Asn Val Asn
Asn100 105 110Ile Ala Asn Met Tyr Ser Leu His Ser Trp Val Gly Leu
Ile Ala Val115 120 125Ile Cys Tyr Leu Leu Gln Leu Leu Ser Gly Phe
Ser Val Phe Leu Leu130 135 140Pro Trp Ala Pro Leu Ser Leu Arg Ala
Phe Leu Met Pro Ile His Val145 150 155 160Tyr Ser Gly Ile Val Ile
Phe Gly Thr Val Ile Ala Thr Ala Leu Met165 170 175Gly Leu Thr Glu
Lys Leu Ile Phe Ser Leu Arg Asp Pro Ala Tyr Ser180 185 190Thr Phe
Pro Pro Glu Gly Val Phe Val Asn Thr Leu Gly Leu Leu Ile195 200
205Leu Val Phe Gly Ala Leu Ile Phe Trp Ile Val Thr Arg Pro Gln
Trp210 215 220Lys Arg Pro Lys Glu Pro Asn Ser Thr Ile Leu His Pro
Asn Gly Gly225 230 235 240Thr Glu Gln Gly Ala Arg Gly Ser Met Pro
Ala Tyr Ser Gly Asn Asn245 250 255Met Asp Lys Ser Asp Ser Glu Leu
Asn Ser Glu Val Ala Ala Arg Lys260 265 270Arg Asn Leu Ala Leu Asp
Glu Ala Gly Gln Arg Ser Thr Met275 280 285532655DNAhomo sapiens
53cgcctagccg cgccggtccc agaagtggcg aaagccgcag ccgagtccag gtcacgccga
60agccgttgcc cttttaaggg ggagccttga aacggcgcct gggttccatg tttgcatccg
120cctcgcggga aggaaactcc atgttgtaac aaagtttcct ccgcgccccc
tccctccccc 180tcccccctag aacctggctc ccctcccctc cggagctcgc
ggggatccct ccctcccacc 240cctcccctcc cccccgcgcc ccgattccgg
ccccagccgg gggggaggcc gggcgcccgg 300gccagagtcc ggccggagcg
gagcgcgccc ggccccatgg acagctcggc cgtcattact 360cagatcagca
aggaggaggc tcggggcccg ctgcggggca aaggtgacca gaagtcagca
420gcttcccaga agccccgaag ccggggcatc ctccactcac tcttctgctg
tgtctgccgg 480gatgatgggg aggccctgcc tgctcacagc ggggcgcccc
tgcttgtgga ggagaatgga 540gccatcccta agcagacccc agtccaatac
ctgctccctg aggccaaggc ccaggactca 600gacaagatct gcgtggtcat
cgacctggac gagaccctgg tgcacagctc cttcaagcca 660gtgaacaacg
cggacttcat catccctgtg gagattgatg gggtggtcca ccaggtctac
720gtgttgaagc gtcctcacgt ggatgagttc ctgcagcgaa tgggcgagct
ctttgaatgt 780gtgctgttca ctgctagcct cgccaagtac gcagacccag
tagctgacct gctggacaaa 840tggggggcct tccgggcccg gctgtttcga
gagtcctgcg tcttccaccg ggggaactac 900gtgaaggacc tgagccggtt
gggtcgagac ctgcggcggg tgctcatcct ggacaattca 960cctgcctcct
atgtcttcca tccagacaat gctgtaccgg tggcctcgtg gtttgacaac
1020atgagtgaca cagagctcca cgacctcctc cccttcttcg agcaactcag
ccgtgtggac 1080gacgtgtact cagtgctcag gcagccacgg ccagggagct
agtgagggtg atggggccag 1140gacctgcccc tgaccaatga tacccacacc
tcctcccagg aagactgccc aggcctttgt 1200taggaaaacc catgggccgc
cgccacactc agtgccatgg ggaagcgggc gtctccccca 1260ccagccccac
caggcggtgt aggggcagca ggctgcactg aggaccgtga gctccaggcc
1320ccgtgtcagt gccttcaaac ctcctcccct attctcaggg gacctggggg
gccctgcctg 1380ctgctccctt tttctgtctc tgtccatgct gccatgtttc
tctgctgcca aattgggccc 1440cttggcccct tccggttctg cttcctgggg
gcagggttcc tgccttggac ccccagtctg 1500ggaacggtgg acatcaagtg
ccttgcatag agccccctct tccccgccca gctttcccag 1560gggcacagct
ctaggctggg aggggagaac cagcccctcc ccctgcccca cctcctccct
1620tgggactgag agggccccta ccaacctttg cctctgcctt ggagggaggg
gaggtctgtt 1680accactgggg aaggcagcag gagtctgtcc ttcaggcccc
acagtgcagc ttctccaggg 1740ccgacagctg agggctgctc cctgcatcat
ccaagcaatg acctcagact tctgccttaa 1800ccagccccgg ggcttggctc
ccccagctct gagcgtgggg gcataggcag gacccccctt 1860gtggtgccat
ataaatatgt acatgtgtat atagattttt aggggaagga gagagggaag
1920ggtcagggta gagacacccc tcccttgccc ctttcctggg cccagaagtt
ggggggaggg 1980agggaaagga tttttacatt ttttaaactg ctattttctg
aatggaacaa gctgggccaa 2040ggggcccagg ccctgtcctc tgtccctcac
acccctttgc tccgttcatt cattcaaaaa 2100aacatttctt gagcaccttc
tgtgcccagc atatgctagg cccaccagct aagtgtgtgt 2160ggggggtctc
tacgccagct catcagtgcc tccttgccca tccttcaccg gtgcctttgg
2220gggatctgta ggaggtggga ccttctgtgg ggtttgggga tctccaggaa
gcccgaccaa 2280gctgtcccct tcccctgtgc caacccatct cctacagccc
cctgcctgat cccctgctgg 2340ctgggggcag ctcccaggat atcctgcctt
ccaactgttt ctgaagcccc tcctcctaac 2400atggcgattc cggaggtcaa
ggccttgggc tctccccagg gtctaacggt taaggggacc 2460cacataccag
tgccaagggg gatgtcaagt ggtgatgtcg ttgtgctccc ctcccccaga
2520gcgggtgggc ggggggtgaa tatggttggc ctgcatcagg tggccttccc
atttaagtgc 2580cttctctgtg actgagagcc ctagtgtgat gagaactaaa
gagaaagcca gacccctaaa 2640aaaaaaaaaa aaaaa 265554261PRThomo sapiens
54Met Asp Ser Ser Ala Val Ile Thr Gln Ile Ser Lys Glu Glu Ala Arg1
5 10 15Gly Pro Leu Arg Gly Lys Gly Asp Gln Lys Ser Ala Ala Ser Gln
Lys20 25 30Pro Arg Ser Arg Gly Ile Leu His Ser Leu Phe Cys Cys Val
Cys Arg35 40 45Asp Asp Gly Glu Ala Leu Pro Ala His Ser Gly Ala Pro
Leu Leu Val50 55 60Glu Glu Asn Gly Ala Ile Pro Lys Gln Thr Pro Val
Gln Tyr Leu Leu65 70 75 80Pro Glu Ala Lys Ala Gln Asp Ser Asp Lys
Ile Cys Val Val Ile Asp85 90 95Leu Asp Glu Thr Leu Val His Ser Ser
Phe Lys Pro Val Asn Asn Ala100 105 110Asp Phe Ile Ile Pro Val Glu
Ile Asp Gly Val Val His Gln Val Tyr115 120 125Val Leu Lys Arg Pro
His Val Asp Glu Phe Leu Gln Arg Met Gly Glu130 135 140Leu Phe Glu
Cys Val Leu Phe Thr Ala Ser Leu Ala Lys Tyr Ala Asp145 150 155
160Pro Val Ala Asp Leu Leu Asp Lys Trp Gly Ala Phe Arg Ala Arg
Leu165 170 175Phe Arg Glu Ser Cys Val Phe His Arg Gly Asn Tyr Val
Lys Asp Leu180 185 190Ser Arg Leu Gly Arg Asp Leu Arg Arg Val Leu
Ile Leu Asp Asn Ser195 200 205Pro Ala Ser Tyr Val Phe His Pro Asp
Asn Ala Val Pro Val Ala Ser210 215 220Trp Phe Asp Asn Met Ser Asp
Thr Glu Leu His Asp Leu Leu Pro Phe225 230 235 240Phe Glu Gln Leu
Ser Arg Val Asp Asp Val Tyr Ser Val Leu Arg Gln245 250 255Pro Arg
Pro Gly Ser260553804DNAhomo sapiens 55gcccgagcga gggcgcttcg
ctcccagcca ggacatggcc gcacctctcc gcatcaggag 60cgccggctca cggacttctc
gcccaactcc ctgagcgctc cctcgtttcg atctttagaa 120aaccccgctt
tctttctggg gccgtgacga ggggcaggga gcggcgagca aggatgcgtt
180gaggaccgcg agggcgcgcg tctcgggtgc cgccgtgggt cccgacgcgg
aagccgagcc 240gcctccgcct gcctcgactt ccccacagcg cttccgccgc
cgcctgccgt gcttgtatgt 300gcagaaagaa gccggacacc atgatcctaa
cacaaattga agccaaggaa gcttgtgatt 360ggctacgggc aactggtttc
ccccagtatg cacagcttta tgaagatttc ctgttcccca 420tcgatatttc
cttggtcaag agagagcatg attttttgga cagagatgcc attgaggctc
480tataggcgtc taaatacttt aaacaaatgt gcggtgatga agctagaaat
tagtcctcat 540cggaaacgag tgacgattca gacgaggatg agccttgtgc
catcagtggc aaatggactt 600tccaaaggga cagcaagagg tggtcccggc
ttgaagagtt tgatgtcttt tctccaaaac 660aagacctggt ccctgggtcc
ccagacgact cccacccgaa ggacggcccc agccccggag 720gcacgctgat
ggacctcagc gagcgccagg aggtgtcttc cgtccgcagc ctcagcagca
780ctggcagcct ccccagccac gcgcccccca gcgaggatgc tgccaccccc
cggactaact 840ccgtcatcag cgtttgctcc tccagcaact tggcaggcaa
tgacgactct ttcggcagcc 900tgccctctcc caaggaactg tccagcttca
gcttcagcat gaaaggccac gaaaaaactg 960ccaagtccaa gacgcgcagt
ctgctgaaac ggatggagag cctgaagctc aagagctccc 1020atcacagcaa
gcacaaagcg ccctcaaagc tggggttgat catcagcggg cccatcttgc
1080aagaggggat ggatgaggag aagctgaagc agctcaactg cgtggagatc
tccgccctca 1140atggcaaccg catcaacgtc cccatggtac gaaagaggag
cgtttccaac tccacgcaga 1200ccagcagcag cagcagccag tcggagacca
gcagcgcggt cagcacgccc agccctgtta 1260cgaggacccg gagcctcagt
gcgtgcaaca agcgggtggg catgtactta gagggcttcg 1320atcctttcaa
tcagtcaaca tttaacaacg tgatggagca gaactttaag aaccgcgaga
1380gctacccaga ggacacggtg ttctacatcc ctgaagatca caagcctggc
actttcccca 1440aagctctcac caatggcagt ttctccccct cggggaataa
cggctctgtg aactggagga 1500cgggaagctt ccacggccct ggccacatca
gcctcaggag ggaaaacagt agcgacagcc 1560ccaaggaact gaagagacgc
aattcttcca gctccatgag cagccgcctg agcatctacg 1620acaacgtgcc
gggctccatc ctctactcca gttcagggga cctggcggat ctggagaacg
1680aggacatctt ccccgagctg gacgacatcc tctaccacgt gaaggggatg
cagcggatag 1740tcaatcagtg gtcggagaag ttttctgatg agggagattc
ggactcagcc ctggactcgg 1800tctctccctg cccgtcctct ccaaaacaga
tacacctgga tgtggacaac gaccgaacca 1860cacccagcga cctggacagc
acaggcaact ccctgaatga accggaagag ccctccgaga 1920tcccggaaag
aagggattct ggggttgggg cttccctaac caggtccaac aggcaccgac
1980tgagatggca cagtttccag agctcacatc ggccaagcct caactctgta
tcactacaga 2040ttaactgcca gtctgtggcc cagatgaacc tgctgcagaa
atactcactc ctaaagctaa 2100cggccctgct ggagaaatac acaccttcta
acaagcatgg ttttagctgg gccgtgccca 2160agttcatgaa gaggatcaag
gttccagact acaaggaccg gagtgtgttt ggggtcccac 2220tgacggtcaa
cgtgcagcgc acaggacaac cgttgcctca gagcatccag caggccatgc
2280gatacctccg gaaccattgt ttggatcagg ttgggctctt cagaaaatcg
ggggtcaagt 2340cccggattca ggctctgcgc cagatgaatg aaggtgccat
agactgtgtc aactacgaag 2400gacagtctgc ttatgacgtg gcagacatgc
tgaagcagta ttttcgagat cttcctgagc 2460cactaatgac gaacaaactc
tcagaaacct ttctacagat ctaccaatat gtgcccaagg 2520accagcgact
gcaggccatc aaggctgcca tcatgctgct gcctgacgag aaccgggagg
2580ttctgcagac cctgctttat ttcctgagcg atgtcacagc agccgtaaaa
gaaaaccaga 2640tgaccccaac caacctggcc gtgtgcttag cgccttccct
cttccatctc aacaccctga 2700agagagagaa ttcctctccc aggggtaatg
caaagaaaac aaagtttggg caaaccagat 2760cagaaagatt tgaatgaaaa
cctagctgcc actcaagggc tggcccatat gatcgccgag 2820tgcaagaagc
ttttccaggt tcccgaggaa atgagccgat gtcgtaattc ctataccgaa
2880caagagctga agcccctcac tctggaagca ctcgggcacc tgggtaatga
tgactcagct 2940gactaccaac acttcctcca ggactgtgtg gatggcctgt
ttaaagaagt caaagagaag 3000tttaaaggct gggtcagcta ctccacttcg
gagcaggctg agctgtccta taagaaggtg 3060agcgaaggac cccctctgag
gctttggagg tcagtcattg aagtccctgc tgtgccagag 3120gaaatcttaa
agcgcctact taaagaacag cacctctggg atgtagacct gttggattca
3180aaagtgatcg aaattctgga cagccaaact gaaatttacc agtatgtcca
aaacagtatg 3240gcacctcatc ctgctcgaga ctacgttgtt ttaagaacct
ggaggactaa tttacccaaa 3300ggagcctgtg cccttttact aacctctgtg
gatcacgatc gcgcacctgt ggtgggtgtg 3360agggttaatg tgctcttgtc
caggtatttg attgaaccct gtgggccagg aaaatccaaa 3420ctcacctaca
tgtgcagagt tgacttaagg ggccacatgc cagaatggta cacaaaatct
3480tttggacatt tgtgtgcagc tgaagttgta aagatccggg attccttcag
taaccagaac 3540actgaaacca aagacaccaa atctaggtga tcactgaagc
aacgcaaccg cttccaccac 3600catggtgttt gtttctagaa cttttgccag
tccttgaaga atgggttctg tgtctaatcc 3660tgaaacaaag aaaactacaa
gctggagtgt aggaattgac tatagcaatt tgatacattt 3720ttaaagctgc
ttcctgtttg ttgagggtct gtattcatag accttgactg gaatatgtaa
3780gactgtgcaa aaaaaaaaaa aaaa 3804561091PRThomo sapiens 56Met Cys
Arg Lys Lys Pro Asp Thr Met Ile Leu Thr Gln Ile Glu Ala1 5 10
15Lys Glu Ala Cys Asp Trp Leu Arg Ala Thr Gly Phe Pro Gln Tyr Ala20
25 30Gln Leu Tyr Glu Asp Phe Leu Phe Pro Ile Asp Ile Ser Leu Val
Lys35 40 45Arg Glu His Asp Phe Leu Asp Arg Asp Ala Ile Glu Ala Leu
Cys Arg50 55 60Arg Leu Asn Thr Leu Asn Lys Cys Ala Val Met Lys Leu
Glu Ile Ser65 70 75 80Pro His Arg Lys Arg Ser Asp Asp Ser Asp Glu
Asp Glu Pro Cys Ala85 90 95Ile Ser Gly Lys Trp Thr Phe Gln Arg Asp
Ser Lys Arg Trp Ser Arg100 105 110Leu Glu Glu Phe Asp Val Phe Ser
Pro Lys Gln Asp Leu Val Pro Gly115 120 125Ser Pro Asp Asp Ser His
Pro Lys Asp Gly Pro Ser Pro Gly Gly Thr130 135 140Leu Met Asp Leu
Ser Glu Arg Gln Glu Val Ser Ser Val Arg Ser Leu145 150 155 160Ser
Ser Thr Gly Ser Leu Pro Ser His Ala Pro Pro Ser Glu Asp Ala165 170
175Ala Thr Pro Arg Thr Asn Ser Val Ile Ser Val Cys Ser Ser Ser
Asn180 185 190Leu Ala Gly Asn Asp Asp Ser Phe Gly Ser Leu Pro Ser
Pro Lys Glu195 200 205Leu Ser Ser Phe Ser Phe Ser Met Lys Gly His
Glu Lys Thr Ala Lys210 215 220Ser Lys Thr Arg Ser Leu Leu Lys Arg
Met Glu Ser Leu Lys Leu Lys225 230 235 240Ser Ser His His Ser Lys
His Lys Ala Pro Ser Lys Leu Gly Leu Ile245 250 255Ile Ser Gly Pro
Ile Leu Gln Glu Gly Met Asp Glu Glu Lys Leu Lys260 265 270Gln Leu
Ser Cys Val Glu Ile Ser Ala Leu Asn Gly Asn Arg Ile Asn275 280
285Val Pro Met Val Arg Lys Arg Ser Val Ser Asn Ser Thr Gln Thr
Ser290 295 300Ser Ser Ser Ser Gln Ser Glu Thr Ser Ser Ala Val Ser
Thr Pro Ser305 310 315 320Pro Val Thr Arg Thr Arg Ser Leu Ser Ala
Cys Asn Lys Arg Val Gly325 330 335Met Tyr Leu Glu Gly Phe Asp Pro
Phe Asn Gln Ser Thr Phe Asn Asn340 345 350Val Val Glu Gln Asn Phe
Lys Asn Arg Glu Ser Tyr Pro Glu Asp Thr355 360 365Val Phe Tyr Ile
Pro Glu Asp His Lys Pro Gly Thr Phe Pro Lys Ala370 375 380Leu Thr
Asn Gly Ser Phe Ser Pro Ser Gly Asn Asn Gly Ser Val Asn385 390 395
400Trp Arg Thr Gly Ser Phe His Gly Pro Gly His Ile Ser Leu Arg
Arg405 410 415Glu Asn Ser Ser Asp Ser Pro Lys Glu Leu Lys Arg Arg
Asn Ser Ser420 425 430Ser Ser Met Ser Ser Arg Leu Ser Ile Tyr Asp
Asn Val Pro Gly Ser435 440 445Ile Leu Tyr Ser Ser Ser Gly Asp Leu
Ala Asp Leu Glu Asn Glu Asp450 455 460Ile Phe Pro Glu Leu Asp Asp
Ile Leu Tyr His Val Lys Gly Met Gln465 470 475 480Arg Ile Val Asn
Gln Trp Ser Glu Lys Phe Ser Asp Glu Gly Asp Ser485 490 495Asp Ser
Ala Leu Asp Ser Val Ser Pro Cys Pro Ser Ser Pro Lys Gln500 505
510Ile His Leu Asp Val Asp Asn Asp Arg Thr Thr Pro Ser Asp Leu
Asp515 520 525Ser Thr Gly Asn Ser Leu Asn Glu Pro Glu Glu Pro Ser
Glu Ile Pro530 535 540Glu Arg Arg Asp Ser Gly Val Gly Ala Ser Leu
Thr Arg Ser Asn Arg545 550 555 560His Arg Leu Arg Trp His Ser Phe
Gln Ser Ser His Arg Pro Ser Leu565 570 575Asn Ser Val Ser Leu Gln
Ile Asn Cys Gln Ser Val Ala Gln Met Asn580 585 590Leu Leu Gln Lys
Tyr Ser Leu Leu Lys Leu Thr Ala Leu Leu Glu Lys595 600 605Tyr Thr
Pro Ser Asn Lys His Gly Phe Ser Trp Ala Val Pro Lys Phe610 615
620Met Lys Arg Ile Lys Val Pro Asp Tyr Lys Asp Arg Ser Val Phe
Gly625 630 635 640Val Pro Leu Thr Val Asn Val Gln Arg Thr Gly Gln
Pro Leu Pro Gln645 650 655Ser Ile Gln Gln Ala Met Arg Tyr Leu Arg
Asn His Cys Leu Asp Gln660 665 670Val Gly Leu Phe Lys Lys Ser Gly
Val Lys Ser Arg Ile Gln Ala Leu675 680 685Arg Gln Met Asn Glu Gly
Ala Ile Asp Cys Val Asn Tyr Glu Gly Gln690 695 700Ser Ala Tyr Asp
Val Ala Asp Met Leu Lys Gln Tyr Phe Arg Asp Leu705 710 715 720Pro
Glu Pro Leu Met Thr Asn Lys Leu Ser Glu Thr Phe Leu Gln Ile725 730
735Tyr Gln Tyr Val Pro Lys Asp Gln Arg Leu Gln Ala Ile Lys Ala
Ala740 745 750Ile Met Leu Leu Pro Asp Glu Asn Arg Val Val Leu Gln
Thr Leu Leu755 760 765Tyr Phe Leu Cys Asp Val Thr Ala Ala Val Lys
Glu Asn Gln Met Thr770 775 780Pro Thr Asn Leu Ala Val Cys Leu Ala
Pro Ser Leu Phe His Leu Asn785 790 795 800Thr Leu Lys Arg Glu Asn
Ser Ser Pro Arg Val Met Gln Arg Lys Gln805 810 815Ser Leu Gly Lys
Pro Asp Gln Lys Asp Leu Asn Glu Asn Leu Ala Ala820 825 830Thr Gln
Gly Leu Ala His Met Ile Ala Glu Cys Lys Lys Leu Phe Gln835 840
845Val Pro Glu Glu Met Ser Arg Cys Arg Asn Ser Tyr Thr Glu Gln
Glu850 855 860Leu Lys Pro Leu Thr Leu Glu Ala Leu Gly His Leu Gly
Asn Asp Asp865 870 875 880Ser Ala Asp Tyr Gln His Phe Leu Gln Asp
Cys Val Asp Gly Leu Phe885 890 895Lys Glu Val Lys Glu Lys Phe Lys
Gly Trp Val Ser Tyr Ser Thr Ser900 905 910Glu Gln Ala Glu Leu Ser
Tyr Lys Lys Val Ser Glu Gly Pro Arg Leu915 920 925Arg Leu Trp Arg
Ser Val Ile Glu Val Pro Ala Val Pro Glu Glu Ile930 935 940Leu Lys
Arg Leu Leu Lys Glu Gln His Leu Trp Asp Val Asp Leu Leu945 950 955
960Asp Ser Lys Val Ile Glu Ile Leu Asp Ser Gln Thr Glu Ile Tyr
Gln965 970 975Tyr Val Gln Asn Ser Met Ala Pro His Pro Ala Arg Asp
Tyr Val Val980 985 990Leu Arg Thr Trp Arg Thr Asn Leu Pro Lys Gly
Ala Cys Ala Leu Leu995 1000 1005Leu Thr Ser Val Asp His Asp Arg Ala
Pro Val Val Gly Val Arg1010 1015 1020Val Asn Val Leu Leu Ser Arg
Tyr Leu Ile Glu Pro Cys Gly Pro1025 1030 1035Gly Lys Ser Lys Leu
Thr Tyr Met Cys Arg Val Asp Leu Arg Gly1040 1045 1050His Met Pro
Glu Trp Tyr Thr Lys Ser Phe Gly His Leu Cys Ala1055 1060 1065Ala
Glu Val Val Lys Ile Arg Asp Ser Phe Ser Asn Gln Asn Thr1070 1075
1080Glu Thr Lys Asp Thr Lys Ser Arg1085 1090572501DNAhomo sapiens
57ctggccccga gcagctgaag cctggggtca gcaggcgctg cgggcgcagc tccggtgcaa
60gcgaggacac gacacatgca gtggcttctg gactgcgcga tgactggacg caagtaactt
120ctaggtctgc agacaagagg aagagaagat gaaggaagac tgtctgccga
gttctcacgt 180gcccatcagt gacagcaagt ccattcagaa gtcggagctc
ttaggcctgc tgaaaaccta 240caactgctac catgagggca agagcttcca
gctgagacac cgtgaggaag aagggactct 300gatcatcgag gggctcctca
acattgcctg ggggctgagg cggcccatcc ggctgcagat 360gcaggatgac
cgggagcagg tgcacctccc ctccacctca tggatgccca gacggcctag
420ctgccctcta aaggagccat cgccccagaa cgggaacatc acagcccagg
ggccaagcat 480tcagccagtg cacaaggctg agagttccac agacagctcg
gggcccctgg aggaggcaga 540ggaggccccc cagctgatgc ggaccaagag
cgacgccagt tgcatgagcc agaggaggcc 600caagtgccgc gcccccggtg
aggcccagcg catccggcga caccggttct ctatcaacgg 660ccacttctac
aatcataaga cctccgtgtt tactccagcc tatggatccg tgaccaatgt
720gagggtcaac agcaccatga caaccctgca ggtgctcacc ctgctgctga
acaaatttag 780ggtggaagat ggccccagtg agttcgcact ctacatcgtt
cacgagtctg gggagcggac 840aaaattaaaa gactgcgagt acccgctgat
ttccagaatc ctgcatgggc catgtgagaa 900gatcgccagg atcttcctga
tggaagctga cttgggcgtg gaagtccccc atgaagtcgc 960tcagtacatt
aagtttgaaa tgccggtgct ggacagtttt gttgaaaaat taaaagaaga
1020ggaagaaaga gaaataatca aactgaccat gaagttccaa gccctgcgtc
tgacgatgct 1080gcagcgcctg gagcagctgg tggaggccaa gtaactggcc
aacacctgcc tcttccaaag 1140tccccagcag tggcaggtgt acactgagcc
ctggttgctg gccccggccg gtcacattga 1200ctgatggcca ccgcctgacg
aatcgagtgc ctgtgtgtct acctctctga agcctgagca 1260ccatgattcc
cacagccagc tcttggctcc aagatgagca cccacaggaa gccgacccag
1320gcctgagggg ccaggaactt gctgggtcag atctgtgtgg ccagccctgt
ccacaccatg 1380cctctcctgc actggagagc agtgctggcc cagcccctgc
ggcttaggct tcatctgctt 1440gcacattgcc tgtcccagag cccctgtggg
tccacaagcc cctgtcctct tccttcatat 1500gagattcttg tctgccctca
tatcacgctg ccccacagga atgctgctgg gaaaagcagg 1560gcctgccagc
aggtatgaga tctagcctgc tttcagccat caccttgcca cagtgtcccc
1620ggcttctaag cctccaatat caccctgtga gcctcgcaca gctcagcccc
aacacagagg 1680tgagaccagg aataaggcca caagtatctc actttctcgc
agggaatcaa tcttagcttc 1740agcagagaga cttaaagcga ttctgacaag
gagctgctgc aagaaacgcg gtcattcaat 1800cgcattgagg agggtccaca
tggcattgag agggtgctgc ccgctcaatg cccagcagca 1860gctctggaag
gcagtgctca gccccatcac cactgtcccg tggatgcctg tgtacctctt
1920gccttttctg ggcttgcgtt tctctcctct agtgggtggg gatgactttc
aatgactttc 1980aatacttccc ctgaaggaag aatgataagg agaaatgtct
gttttgagga aagggctttg 2040aattccccag atactgaaca atttgtgttt
gtgactgatg gagaatttca ggaatgaatg 2100agaaagcctt tgcgaaacta
tgcaacagtt tacatcagtc atgtgaagta tttgtctaaa 2160acagagcaaa
ctgaagacca aattattctc ctgttgaggt ccgtggatgg cagatttaaa
2220gggaagaacc acaaaggctt gcaaagatag gagaggctcc atctctaatg
catgtagaag 2280ctccttacgg gtgcccatca agagcatagc ttggaagcca
ccatgctgtg cggaactgcg 2340tcagggcaaa tgtcacagca ggatttcccc
aacccagctc catcatcaca gacacagaga 2400gctgcagggg aggcctgccc
actgttttgt cgactctgcc ctcctctggc agcatagatc 2460cttaggtgct
caataaaggt gtgctgtatt gaactgaaga a 250158321PRThomo sapiens 58Met
Lys Glu Asp Cys Leu Pro Ser Ser His Val Pro Ile Ser Asp Ser1 5 10
15Lys Ser Ile Gln Lys Ser Glu Leu Leu Gly Leu Leu Lys Thr Tyr Asn20
25 30Cys Tyr His Glu Gly Lys Ser Phe Gln Leu Arg His Arg Glu Glu
Glu35 40 45Gly Thr Leu Ile Ile Glu Gly Leu Leu Asn Ile Ala Trp Gly
Leu Arg50 55 60Arg Pro Ile Arg Leu Gln Met Gln Asp Asp Arg Glu Gln
Val His Leu65 70 75 80Pro Ser Thr Ser Trp Met Pro Arg Arg Pro Ser
Cys Pro Leu Lys Glu85 90 95Pro Ser Pro Gln Asn Gly Asn Ile Thr Ala
Lys Gly Pro Ser Ile Gln100 105 110Pro Val His Lys Ala Glu Ser Ser
Thr Asp Ser Ser Gly Pro Leu Glu115 120 125Glu Ala Glu Glu Ala Pro
Gln Leu Met Arg Thr Lys Ser Asp Ala Ser130 135 140Cys Met Ser Gln
Arg Arg Pro Lys Cys Arg Ala Pro Gly Glu Ala Gln145 150 155 160Arg
Ile Arg Arg His Arg Phe Ser Ile Asn Gly His Phe Tyr Asn His165 170
175Lys Thr Ser Val Phe Thr Pro Ala Tyr Gly Ser Val Thr Asn Val
Arg180 185 190Val Asn Ser Thr Met Thr Thr Leu Gln Val Leu Thr Leu
Leu Leu Asn195 200 205Lys Phe Arg Val Glu Asp Gly Pro Ser Glu Phe
Ala Leu Tyr Ile Val210 215 220His Glu Ser Gly Glu Arg Thr Lys Leu
Lys Asp Cys Glu Tyr Pro Leu225 230 235 240Ile Ser Arg Ile Leu His
Gly Pro Cys Glu Lys Ile Ala Arg Ile Phe245 250 255Leu Met Glu Ala
Asp Leu Gly Val Glu Val Pro His Glu Val Ala Gln260 265 270Tyr Ile
Lys Phe Glu Met Pro Val Leu Asp Ser Phe Val Glu Lys Leu275 280
285Lys Glu Glu Glu Glu Arg Glu Ile Ile Lys Leu Thr Met Lys Phe
Gln290 295 300Ala Leu Arg Leu Thr Met Leu Gln Arg Leu Glu Gln Leu
Val Glu Ala305 310 315 320Lys591152DNAhomo sapiens 59atgagtgcac
ttttccttgg tgtgggagtg agggcagagg aagctggagc gagggtgcaa 60caaaacgttc
caagtgggac agatactgga gatcctcaaa gtaagcccct cggtgactgg
120gctgctggca ccatggaccc agagagcagt atctttattg aggatgccat
taagtatttc 180aaggaaaaag tgagcacaca gaatctgcta ctcctgctga
ctgataatga ggcctggaac 240ggattcgtgg ctgctgctga actgcccagg
aatgaggcag atgagctccg taaagctctg 300gacaaccttg caagacaaat
gatcatgaaa gacaaaaact ggcacgataa aggccagcag 360tacagaaact
ggtttctgaa agagtttcct cggttgaaaa gtgagcttga ggataacata
420agaaggctcc gtgcccttgc agatggggtt cagaaggtcc acaaaggcac
caccatcgcc 480aatgtggtgt ctggctctct cagcatttcc tctggcatcc
tgaccctcgt cggcatgggt 540ctggcaccct tcacagaggg aggcagcctt
gtactcttgg aacctgggat ggagttggga 600atcacagccg ctttgaccgg
gattaccagc agtaccatgg actacggaaa gaagtggtgg 660acacaagccc
aagcccacga cctggtcatc aaaagccttg acaaattgaa ggaggtgagg
720gagtttttgg gtgagaacat atccaacttt ctttccttag ctggcaatac
ttaccaactc 780acacgaggca ttgggaagga catccgtgcc ctcagacgag
ccagagccaa tcttcagtca 840gtaccgcatg cctcagcctc acgcccccgg
gtcactgagc caatctcagc tgaaagcggt 900gaacaggtgg agagggttaa
tgaacccagc atcctggaaa tgagcagagg agtcaagctc 960acggatgtgg
cccctgtaag cttctttctt gtgctggatg tagtctacct cgtgtacgaa
1020tcaaagcact tacatgaggg ggcaaagtca gagacagctg aggagctgaa
gaaggtggct 1080caggagctgg aggagaagct aaacattctc aacaataatt
ataagattct gcaggcggac 1140caagaactgt ga 115260383PRThomo sapiens
60Met Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly1
5 10 15Ala Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp
Pro20 25 30Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp
Pro Glu35 40 45Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys
Glu Lys Val50 55 60Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn
Glu Ala Trp Asn65 70 75 80Gly Phe Val Ala Ala Ala Glu Leu Pro Arg
Asn Glu Ala Asp Glu Leu85 90 95Arg Lys Ala Leu Asp Asn Leu Ala Arg
Gln Met Ile Met Lys Asp Lys100 105 110Asn Trp His Asp Lys Gly Gln
Gln Tyr Arg Asn Trp Phe Leu Lys Glu115 120 125Phe Pro Arg Leu Lys
Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg130 135 140Ala Leu Ala
Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala145 150 155
160Asn Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr
Leu165 170 175Val Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser
Leu Val Leu180 185 190Leu Glu Pro Gly Met Glu Leu Gly Ile Thr Ala
Ala Leu Thr Gly Ile195 200 205Thr Ser Ser Thr Met Asp Tyr Gly Lys
Lys Trp Trp Thr Gln Ala Gln210 215 220Ala His Asp Leu Val Ile Lys
Ser Leu Asp Lys Leu Lys Glu Val Arg225 230 235 240Glu Phe Leu Gly
Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn245 250 255Thr Tyr
Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg260 265
270Arg Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser
Arg275 280 285Pro Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu
Gln Val Glu290 295 300Arg Val Asn Glu Pro Ser Ile Leu Glu Met Ser
Arg Gly Val Lys Leu305 310 315 320Thr Asp Val Ala Pro Val Ser Phe
Phe Leu Val Leu Asp Val Val Tyr325 330 335Leu Val Tyr Glu Ser Lys
His Leu His Glu Gly Ala Lys Ser Glu Thr340 345 350Ala Glu Glu Leu
Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn355 360 365Ile Leu
Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu370 375
380611761DNAhomo sapiens 61atggctttag agatccacat gtcagacccc
atgtgcctca tcgagaactt taatgagcag 60ctgaaggtta atcaggaagc tttggagatc
ctgtctgcca ttacgcaacc tgtagttgtg 120gtagcgattg tgggcctcta
tcgcactggc aaatcctacc tgatgaacaa gctggctggg 180aagaacaagg
gcttctctgt tgcatctacg gtgcagtctc acaccaaggg aatttggata
240tggtgtgtgc ctcatcccaa ctggccaaat cacacattag ttctgcttga
caccgagggc 300ctgggagatg tagagaaggc tgacaacaag aatgatatcc
agatctttgc actggcactc 360ttactgagca gcacctttgt gtacaatact
gtgaacaaaa ttgatcaggg tgctatcgac 420ctactgcaca atgtgacaga
actgacagat ctgctcaagg caagaaactc acccgacctt 480gacagggttg
aagatcctgc tgactctgcg agcttcttcc cagacttagt gtggactctg
540agagatttct gcttaggcct ggaaatagat gggcaacttg tcacaccaga
tgaatacctg 600gagaattccc taaggccaaa gcaaggtagt gatcaaagag
ttcaaaattt caatttgcct 660cgtctgtgta tacagaagtt ctttccaaaa
aagaaatgct ttatctttga cttacctgct 720caccaaaaaa agcttgccca
acttgaaaca ctgcctgatg atgagctaga gcctgaattt 780gtgcaacaag
tgacagaatt ctgttcctac atctttagcc attctatgac caagactctt
840ccaggtggca tcatggtcaa tggatctcgt ctaaagaacc tggtgctgac
ctatgtcaat 900gccatcagca gtggggatct gccttgcata gagaatgcag
tcctggcctt ggctcagaga 960gagaactcag ctgcagtgca aaaggccatt
gcccactatg accagcaaat gggccagaaa 1020gtgcagctgc ccatggaaac
cctccaggag ctgctggacc tgcacaggac cagtgagagg 1080gaggccattg
aagtcttcat gaaaaactct ttcaaggatg tagaccaaag tttccagaaa
1140gaattggaga ctctactaga
tgcaaaacag aatgacattt gtaaacggaa cctggaagca 1200tcctcggatt
attgctcggc tttacttaag gatatttttg gtcctctaga agaagcagtg
1260aagcagggaa tttattctaa gccaggaggc cataatctct tcattcagaa
aacagaagaa 1320ctgaaggcaa agtactatcg ggagcctcgg aaaggaatac
aggctgaaga agttctgcag 1380aaatatttaa agtccaagga gtctgtgagt
catgcaatat tacagactga ccaggctctc 1440acagagacgg aaaaaaagaa
gaaagaggca caagtgaaag cagaagctga aaaggctgaa 1500gcgcaaaggt
tggcggcgat tcaaaggcag aacgagcaaa tgatgcagga gagggagaga
1560ctccatcagg aacaagtgag acaaatggag atagccaaac aaaattggct
ggcagagcaa 1620cagaaaatgc aggaacaaca gatgcaggaa caggctgcac
agctcagcac aacattccaa 1680gctcaaaata gaagccttct cagtgagctc
cagcacgccc agaggactgt taataacgat 1740gatccatgtg ttttactcta a
176162586PRThomo sapiens 62Met Ala Leu Glu Ile His Met Ser Asp Pro
Met Cys Leu Ile Glu Asn1 5 10 15Phe Asn Glu Gln Leu Lys Val Asn Gln
Glu Ala Leu Glu Ile Leu Ser20 25 30Ala Ile Thr Gln Pro Val Val Val
Val Ala Ile Val Gly Leu Tyr Arg35 40 45Thr Gly Lys Ser Tyr Leu Met
Asn Lys Leu Ala Gly Lys Asn Lys Gly50 55 60Phe Ser Val Ala Ser Thr
Val Gln Ser His Thr Lys Gly Ile Trp Ile65 70 75 80Trp Cys Val Pro
His Pro Asn Trp Pro Asn His Thr Leu Val Leu Leu85 90 95Asp Thr Glu
Gly Leu Gly Asp Val Glu Lys Ala Asp Asn Lys Asn Asp100 105 110Ile
Gln Ile Phe Ala Leu Ala Leu Leu Leu Ser Ser Thr Phe Val Tyr115 120
125Asn Thr Val Asn Lys Ile Asp Gln Gly Ala Ile Asp Leu Leu His
Asn130 135 140Val Thr Glu Leu Thr Asp Leu Leu Lys Ala Arg Asn Ser
Pro Asp Leu145 150 155 160Asp Arg Val Glu Asp Pro Ala Asp Ser Ala
Ser Phe Phe Pro Asp Leu165 170 175Val Trp Thr Leu Arg Asp Phe Cys
Leu Gly Leu Glu Ile Asp Gly Gln180 185 190Leu Val Thr Pro Asp Glu
Tyr Leu Glu Asn Ser Leu Arg Pro Lys Gln195 200 205Gly Ser Asp Gln
Arg Val Gln Asn Phe Asn Leu Pro Arg Leu Cys Ile210 215 220Gln Lys
Phe Phe Pro Lys Lys Lys Cys Phe Ile Phe Asp Leu Pro Ala225 230 235
240His Gln Lys Lys Leu Ala Gln Leu Glu Thr Leu Pro Asp Asp Glu
Leu245 250 255Glu Pro Glu Phe Val Gln Gln Val Thr Glu Phe Cys Ser
Tyr Ile Phe260 265 270Ser His Ser Met Thr Lys Thr Leu Pro Gly Gly
Ile Met Val Asn Gly275 280 285Ser Arg Leu Lys Asn Leu Val Leu Thr
Tyr Val Asn Ala Ile Ser Ser290 295 300Gly Asp Leu Pro Cys Ile Glu
Asn Ala Val Leu Ala Leu Ala Gln Arg305 310 315 320Glu Asn Ser Ala
Ala Val Gln Lys Ala Ile Ala His Tyr Asp Gln Gln325 330 335Met Gly
Gln Lys Val Gln Leu Pro Met Glu Thr Leu Gln Glu Leu Leu340 345
350Asp Leu His Arg Thr Ser Glu Arg Glu Ala Ile Glu Val Phe Met
Lys355 360 365Asn Ser Phe Lys Asp Val Asp Gln Ser Phe Gln Lys Glu
Leu Glu Thr370 375 380Leu Leu Asp Ala Lys Gln Asn Asp Ile Cys Lys
Arg Asn Leu Glu Ala385 390 395 400Ser Ser Asp Tyr Cys Ser Ala Leu
Leu Lys Asp Ile Phe Gly Pro Leu405 410 415Glu Glu Ala Val Lys Gln
Gly Ile Tyr Ser Lys Pro Gly Gly His Asn420 425 430Leu Phe Ile Gln
Lys Thr Glu Glu Leu Lys Ala Lys Tyr Tyr Arg Glu435 440 445Pro Arg
Lys Gly Ile Gln Ala Glu Glu Val Leu Gln Lys Tyr Leu Lys450 455
460Ser Lys Glu Ser Val Ser His Ala Ile Leu Gln Thr Asp Gln Ala
Leu465 470 475 480Thr Glu Thr Glu Lys Lys Lys Lys Glu Ala Gln Val
Lys Ala Glu Ala485 490 495Glu Lys Ala Glu Ala Gln Arg Leu Ala Ala
Ile Gln Arg Gln Asn Glu500 505 510Gln Met Met Gln Glu Arg Glu Arg
Leu His Gln Glu Gln Val Arg Gln515 520 525Met Glu Ile Ala Lys Gln
Asn Trp Leu Ala Glu Gln Gln Lys Met Gln530 535 540Glu Gln Gln Met
Gln Glu Gln Ala Ala Gln Leu Ser Thr Thr Phe Gln545 550 555 560Ala
Gln Asn Arg Ser Leu Leu Ser Glu Leu Gln His Ala Gln Arg Thr565 570
575Val Asn Asn Asp Asp Pro Cys Val Leu Leu580 58563828DNAhomo
sapiens 63gggggagtga aagcgaaagc ccgggcgact agccgggaga ccagagatct
agcgactgaa 60gcagcatggc caagccgtgt ggggtgcgcc tgagcgggga agcccgcaaa
caggtggagg 120tcttcaggca gaatcttttc caggaggctg aggaattcct
ctacagattc ttgccacaga 180aaatcatata cctgaatcag ctcttgcaag
aggactccct caatgtggct gacttgactt 240ccctccgggc cccactggac
atccccatcc cagaccctcc acccaaggat gatgagatgg 300aaacagataa
gcaggagaag aaagaagtcc ctaagtgtgg atttctccct gggaatgaga
360aagtcctgtc cctgcttgcc ctggttaagc cagaagtctg gactctcaaa
gagaaatgca 420ttctggtgat tacatggatc caacacctga tccccaagat
tgaagatgga aatgattttg 480gggtagcaat ccaggagaag gtgctggaga
gggtgaatgc cgtcaagacc aaagtggaag 540ctttccagac aaccatttcc
aagtacttct cagaacgtgg ggatgctgtg gccaaggcct 600ccaaggagac
tcatgtaatg gattaccggg ccttggtgca tgagcgagat gaggcagcct
660atggggagct cagggccatg gtgctggacc tgagggcctt ctatgctgag
ctttatcata 720tcatcagcag caacctggag aaaattgtca ccccaaaggg
tgaagaaaag ccatctatgt 780actgaacccg ggactagaag gaaaataaat
gatctatatg ttgtgtgg 82864239PRThomo sapiens 64Met Ala Lys Pro Cys
Gly Val Arg Leu Ser Gly Glu Ala Arg Lys Gln1 5 10 15Val Glu Val Phe
Arg Gln Asn Leu Phe Gln Glu Ala Glu Glu Phe Leu20 25 30Tyr Arg Phe
Leu Pro Gln Lys Ile Ile Tyr Leu Asn Gln Leu Leu Gln35 40 45Glu Asp
Ser Leu Asn Val Ala Asp Leu Thr Ser Leu Arg Ala Pro Leu50 55 60Asp
Ile Pro Ile Pro Asp Pro Pro Pro Lys Asp Asp Glu Met Glu Thr65 70 75
80Asp Lys Gln Glu Lys Lys Glu Val Pro Lys Cys Gly Phe Leu Pro Gly85
90 95Asn Glu Lys Val Leu Ser Leu Leu Ala Leu Val Lys Pro Glu Val
Trp100 105 110Thr Leu Lys Glu Lys Cys Ile Leu Val Ile Thr Trp Ile
Gln His Leu115 120 125Ile Pro Lys Ile Glu Asp Gly Asn Asp Phe Gly
Val Ala Ile Gln Glu130 135 140Lys Val Leu Glu Arg Val Asn Ala Val
Lys Thr Lys Val Glu Ala Phe145 150 155 160Gln Thr Thr Ile Ser Lys
Tyr Phe Ser Glu Arg Gly Asp Ala Val Ala165 170 175Lys Ala Ser Lys
Glu Thr His Val Met Asp Tyr Arg Ala Leu Val His180 185 190Glu Arg
Asp Glu Ala Ala Tyr Gly Glu Leu Arg Ala Met Val Leu Asp195 200
205Leu Arg Ala Phe Tyr Ala Glu Leu Tyr His Ile Ile Ser Ser Asn
Leu210 215 220Glu Lys Ile Val Thr Pro Lys Gly Glu Glu Lys Pro Ser
Met Tyr225 230 235652578DNAhomo sapiens 65cttttgtctc tcagctattt
tttgttccct atgtttgtag gatggaaagg cagatgtaaa 60gtccctcatg gcgaaatata
acacgggggg caacccgaca gaggatgtct cagtcaatag 120ccgacccttc
agagtcacag ggccaaactc atcttcagga atacaagcaa gaaagaactt
180attcaacaac caaggaaatg ccagccctcc tgcaggaccc agcaatgtac
ctaagtttgg 240gtccccaaag ccacctgtgg cagtcaaacc ttcttctgag
gaaaagcctg acaaggaacc 300caagcccccg tttctaaagc ccactggagc
aggccaaaga ttcggaacac cagccagctt 360gaccaccaga gaccccgagg
cgaaagtggg atttctgaaa cctgtaggcc ccaagcccat 420caacttgccc
aaagaagatt ccaaacctac atttccctgg cctcctggaa acaagccatc
480tcttcacagt gtaaaccaag accatgactt aaagccacta ggcccgaaat
ctgggcctac 540tcctccaacc tcagaaaatg aacagaagca agcgtttccc
aaattgactg gggttaaagg 600gaaatttatg tcagcatcac aagatcttga
acccaagccc ctcttcccca aacccgcctt 660tggccagaag ccgcccctaa
gtaccgagaa ctcccatgaa gacgaaagcc ccatgaagaa 720tgtgtcttca
tcaaaagggt ccccagctcc cctgggagtc aggtccaaaa gcggcccttt
780aaaaccagca agggaagact cagaaaataa agaccatgca ggggagattt
caagtttgcc 840ctttcctgga gtggttttga aacctgctgc gagcagggga
ggcccaggtg tctccaaaaa 900tggtgaagaa aaaaaggaag ataggaagat
agatgctgct aagaacacct tccagagcaa 960aataaatcag gaagagttgg
cctcagggac tcctcctgcc aggttcccta aggccccttc 1020taagctgaca
gtgggggggc catggggcca aagtcaggaa aaggaaaagg gagacaagaa
1080ttcagccacc ccgaaacaga agccattgcc tcccttgttt accttgggtc
cacctccacc 1140aaaacccaac agaccaccaa atgttgacct gacgaaattc
cacaaaacct cttctggaaa 1200cagtactagc aaaggccaga cgtcttactc
aacaacttcc ctgccaccac ctccaccatc 1260ccatccggcc agccaaccac
cattgccagc atctcaccca tcacaaccac cagtcccaag 1320cctacctccc
agaaacatta aacctccgtt tgacctaaaa agccctgtca atgaagacaa
1380tcaagatggt gtcacgcact ctgatggtgc tggaaatcta gatgaggaac
aagacagtga 1440aggagaaaca tatgaagaca tagaagcatc caaagaaaga
gagaagaaaa gggaaaagga 1500agaaaagaag aggttagagc tggagaaaaa
ggaacagaaa gagaaagaaa agaaagaaca 1560agaaataaag aagaaattta
aactaacagg ccctattcaa gtcatccatc ttgcaaaagc 1620ttgttgtgat
gtcaaaggag gaaagaatga actgagcttc aagcaaggag agcaaattga
1680aatcatccgc atcacagaca acccagaagg aaaatggttg ggcagaacag
caaggggttc 1740atatggctat attaaaacaa ctgctgtaga gattgactat
gattctttga aactgaaaaa 1800agactctctt ggtgcccctt caagacctat
tgaagatgac caagaagtat atgatgatgt 1860tgcagagcag gatgatatta
gcagccacag tcagagtgga agtggaggga tattccctcc 1920accaccagat
gatgacattt atgatgggat tgaagaggaa gatgctgatg atggtttccc
1980tgctcctcct aaacaattgg acatgggaga tgaagtttac gatgatgtgg
atacctctga 2040tttccctgtt tcatcagcag agatgagtca aggaactaat
tttggaaaag ctaagacaga 2100agaaaaggac cttaagaagc taaaaaagca
ggaaaaagaa gaaaaagact tcaggaaaaa 2160atttaaatat gatggtgaaa
ttagagtcct atattcaact aaagttacaa cttccataac 2220ttctaaaaag
tggggaacca gagatctaca ggtaaaacct ggtgaatctc tagaagttat
2280acaaaccaca gatgacacaa aagttctctg cagaaatgaa gaagggaaat
atggttatgt 2340ccttcggagt tacctagcgg acaatgatgg agagatctat
gatgatattg ctgatggctg 2400catctatgac aatgactagc actcaacttt
ggtcattctg ctgtgttcat taggtgccaa 2460tgtgaagtct ggattttaat
tggcatgtta ttgggtatca agaaaattaa tgcacaaaac 2520cacttattat
catttgttat gaaatcccaa ttatctttac aaagtgttta aagtttga
257866783PRThomo sapiens 66Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro
Thr Glu Asp Val Ser Val1 5 10 15Asn Ser Arg Pro Phe Arg Val Thr Gly
Pro Asn Ser Ser Ser Gly Ile20 25 30Gln Ala Arg Lys Asn Leu Phe Asn
Asn Gln Gly Asn Ala Ser Pro Pro35 40 45Ala Gly Pro Ser Asn Val Pro
Lys Phe Gly Ser Pro Lys Pro Pro Val50 55 60Ala Val Lys Pro Ser Ser
Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro65 70 75 80Pro Phe Leu Lys
Pro Thr Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala85 90 95Ser Leu Thr
Thr Arg Asp Pro Glu Ala Lys Val Gly Phe Leu Lys Pro100 105 110Val
Gly Pro Lys Pro Ile Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr115 120
125Phe Pro Trp Pro Pro Gly Asn Lys Pro Ser Leu His Ser Val Asn
Gln130 135 140Asp His Asp Leu Lys Pro Leu Gly Pro Lys Ser Gly Pro
Thr Pro Pro145 150 155 160Thr Ser Glu Asn Glu Gln Lys Gln Ala Phe
Pro Lys Leu Thr Gly Val165 170 175Lys Gly Lys Phe Met Ser Ala Ser
Gln Asp Leu Glu Pro Lys Pro Leu180 185 190Phe Pro Lys Pro Ala Phe
Gly Gln Lys Pro Pro Leu Ser Thr Glu Asn195 200 205Ser His Glu Asp
Glu Ser Pro Met Lys Asn Val Ser Ser Ser Lys Gly210 215 220Ser Pro
Ala Pro Leu Gly Val Arg Ser Lys Ser Gly Pro Leu Lys Pro225 230 235
240Ala Arg Glu Asp Ser Glu Asn Lys Asp His Ala Gly Glu Ile Ser
Ser245 250 255Leu Pro Phe Pro Gly Val Val Leu Lys Pro Ala Ala Ser
Arg Gly Gly260 265 270Pro Gly Val Ser Lys Asn Gly Glu Glu Lys Lys
Glu Asp Arg Lys Ile275 280 285Asp Ala Ala Lys Asn Thr Phe Gln Ser
Lys Ile Asn Gln Glu Glu Leu290 295 300Ala Ser Gly Thr Pro Pro Ala
Arg Phe Pro Lys Ala Pro Ser Lys Leu305 310 315 320Thr Val Gly Gly
Pro Trp Gly Gln Ser Gln Glu Lys Glu Lys Gly Asp325 330 335Lys Asn
Ser Ala Thr Pro Lys Gln Lys Pro Leu Pro Pro Leu Phe Thr340 345
350Leu Gly Pro Pro Pro Pro Lys Pro Asn Arg Pro Pro Asn Val Asp
Leu355 360 365Thr Lys Phe His Lys Thr Ser Ser Gly Asn Ser Thr Ser
Lys Gly Gln370 375 380Thr Ser Tyr Ser Thr Thr Ser Leu Pro Pro Pro
Pro Pro Ser His Pro385 390 395 400Ala Ser Gln Pro Pro Leu Pro Ala
Ser His Pro Ser Gln Pro Pro Val405 410 415Pro Ser Leu Pro Pro Arg
Asn Ile Lys Pro Pro Phe Asp Leu Lys Ser420 425 430Pro Val Asn Glu
Asp Asn Gln Asp Gly Val Thr His Ser Asp Gly Ala435 440 445Gly Asn
Leu Asp Glu Glu Gln Asp Ser Glu Gly Glu Thr Tyr Glu Asp450 455
460Ile Glu Ala Ser Lys Glu Arg Glu Lys Lys Arg Glu Lys Glu Glu
Lys465 470 475 480Lys Arg Leu Glu Leu Glu Lys Lys Glu Gln Lys Glu
Lys Glu Lys Lys485 490 495Glu Gln Glu Ile Lys Lys Lys Phe Lys Leu
Thr Gly Pro Ile Gln Val500 505 510Ile His Leu Ala Lys Ala Cys Cys
Asp Val Lys Gly Gly Lys Asn Glu515 520 525Leu Ser Phe Lys Gln Gly
Glu Gln Ile Glu Ile Ile Arg Ile Thr Asp530 535 540Asn Pro Glu Gly
Lys Trp Leu Gly Arg Thr Ala Arg Gly Ser Tyr Gly545 550 555 560Tyr
Ile Lys Thr Thr Ala Val Glu Ile Asp Tyr Asp Ser Leu Lys Leu565 570
575Lys Lys Asp Ser Leu Gly Ala Pro Ser Arg Pro Ile Glu Asp Asp
Gln580 585 590Glu Val Tyr Asp Asp Val Ala Glu Gln Asp Asp Ile Ser
Ser His Ser595 600 605Gln Ser Gly Ser Gly Gly Ile Phe Pro Pro Pro
Pro Asp Asp Asp Ile610 615 620Tyr Asp Gly Ile Glu Glu Glu Asp Ala
Asp Asp Gly Phe Pro Ala Pro625 630 635 640Pro Lys Gln Leu Asp Met
Gly Asp Glu Val Tyr Asp Asp Val Asp Thr645 650 655Ser Asp Phe Pro
Val Ser Ser Ala Glu Met Ser Gln Gly Thr Asn Phe660 665 670Gly Lys
Ala Lys Thr Glu Glu Lys Asp Leu Lys Lys Leu Lys Lys Gln675 680
685Glu Lys Glu Glu Lys Asp Phe Arg Lys Lys Phe Lys Tyr Asp Gly
Glu690 695 700Ile Arg Val Leu Tyr Ser Thr Lys Val Thr Thr Ser Ile
Thr Ser Lys705 710 715 720Lys Trp Gly Thr Arg Asp Leu Gln Val Lys
Pro Gly Glu Ser Leu Glu725 730 735Val Ile Gln Thr Thr Asp Asp Thr
Lys Val Leu Cys Arg Asn Glu Glu740 745 750Gly Lys Tyr Gly Tyr Val
Leu Arg Ser Tyr Leu Ala Asp Asn Asp Gly755 760 765Glu Ile Tyr Asp
Asp Ile Ala Asp Gly Cys Ile Tyr Asp Asn Asp770 775 78067618DNAhomo
sapiens 67gcggccgctc cgcaggcaga gaagccggga gcgtttgagg cggcggcggc
acgagcgatg 60gcaggaatag agttggagcg gtgccagcag caggcgaacg aggtgacgga
aattatgcgt 120aacaacttcg gcaaggtcct ggagcgtggt gtgaagctgg
ccgaactgca gcagcgttca 180gaccaactcc tggatatgag ctcaaccttc
aacaagacta cacagaacct ggcccagaag 240aagtgctggg agaacatccg
ttaccggatc tgcgtggggc tggtggtggt tggtgtcctg 300ctcatcatcc
tgattgtgct gctggtcgtc tttctccctc agagcagtga cagcagtagt
360gccccacgga cccaggatgc aggcattgcc tcagggcctg ggaactgacc
cagctggtcc 420tgaaggagaa gcccaatggc tgcactggcc gattctggtc
tccaaggacc ttggtgtttg 480ctctccctga cccagcccag tgagtgccaa
agggcagccc caacatgtgc acccctgcat 540tcccgtcatg cacagacttg
cccttgagca ggccgctgta ctggccagct gggcaacccc 600cctggagctc ataaaaat
61868116PRThomo sapiens 68Met Ala Gly Ile Glu Leu Glu Arg Cys Gln
Gln Gln Ala Asn Glu Val1 5 10 15Thr Glu Ile Met Arg Asn Asn Phe Gly
Lys Val Leu Glu Arg Gly Val20 25 30Lys Leu Ala Glu Leu Gln Gln Arg
Ser Asp Gln Leu Leu Asp Met Ser35 40 45Ser Thr Phe Asn Lys Thr Thr
Gln Asn Leu Ala Gln Lys Lys Cys Trp50 55 60Glu Asn Ile Arg Tyr Arg
Ile Cys Val Gly Leu Val Val Val Gly Val65 70 75 80Leu Leu Ile Ile
Leu Ile Val Leu Leu Val Val Phe Leu Pro Gln Ser85 90 95Ser Asp Ser
Ser Ser Ala Pro Arg Thr Gln Asp Ala Gly Ile Ala Ser100 105 110Gly
Pro Gly Asn115691316DNAhomo sapiens 69gggtttgggg tagaagggag
ggagggggca ggacagtgtg gaatctctag ggtgtatggg 60taggtagggg gcacagttag
ttctaagtgg gcttttatgc taaaagcctc tggggatatc 120tgttttgaaa
ataaagatag gtgtcccctc cttgctgtca tctagcccag acactctgct
180tgctctctgg ctgtctgctc cctgggaagg ctttaggagg accacccagg
acaggatgac 240catgctgcca tctgctctgg agctgggtct cagtgcagag
ggacagtgac tgtggatggt 300tgcagtctct ggtgggaggt gaggatagaa
gtgataaaga gctaagagga gcttctggga 360gccttggagg aggtcagtct
tgcagtggtg aagccaggac ataggagatg gagcagggct 420gtgagaggag
gagattctga ggaggatgca
ggggaaatct tgtctgttaa tgaaatagga 480gtggggtggg gtttggggtg
gggtggtcat tgccgtttga gctgctgatt ttcatgagtc 540gccttcaaaa
ctctcgtgta gggttgacaa tgtggggggg tgggggatcc agcttattct
600tttattttca agtccattct tggggctggt ggggaggcag gagaataccc
ctccctaagc 660ccttagtgtg tgccgagctt gctttgtgat gttggcaggg
gaggggagac ctgggtggtg 720actgagttcc ctttatcaaa cccttcagtg
ggcacaaaat tgagtgcttg attttaggtt 780ttattttttt atgaatgtcc
aaatctgtgt ttccccctgc cctcccagac tgtgtggcca 840gttgaaagtg
tctggtttgt gttcatctct ccctcatttc tggagcaggg cctgagaccc
900tgccacatct cctatgctct gcatccacgc ctcttttgga cattaaaggt
tgattgatgc 960acctctgcac tgtttgggtc tctttgggga tgaggggttg
gcatggtggc agtggtgcca 1020cacagtgggt gagggtggag agtctccagg
gtggaataga atggggactg aagggaagac 1080cagccactag atactgattg
gcctgtagca gcacttattt gtgcctaggc ttatgcccct 1140taagtagagg
aaaactaacc agcagcactc acccttaagg gctcctgggt tctgccttcc
1200ttggtggtga tggccaggtg aatcatattt tgtgtctttg ggatagtaac
tgctaccttc 1260ccagctgccg tcatggacct gcctgagctt tgctgcttca
acttttgccc aaagct 1316703517DNAhomo sapiens 70ccgtaaagcg gtggagaatc
tcaagcatgt gcatttaatt gaggaatagc agaagggcta 60aagcaaccaa gaaaagaagt
gtgggtattt ttgttaagta aaacagccca agtgcttctg 120gaggtgggtt
tctaccaaga tagaggaaaa gggctgaatt ccctctaagt gggacagccg
180agctcaggat gtgcttccca gcttcactgg ttaatttgac ctgaacctat
ttaaagatcc 240cttctgcccc tgaagaccta tccgcactca aattctaaca
tgaagaaatc tactcgaatg 300catcctttac tttgaatgag ctctattcgg
ttgcatgtta tatgtgattt ccttcctccc 360aactgtttcc actgagcgca
cccagtctcc cctagtcttc ctctgtgggt gtgatttttg 420tgatttttac
aaacaaaacc cttgaagttc ttggcagatg tgtttgtttc tgtttgcatg
480tactgcagat accccaggac aagcggggga ttcatttttc agccattcag
ttgtttcctc 540aataatccgc agcaaagtga aaatattctt agcactcaga
ctgtacttag agtgttttct 600cagtccagtc tgtacagtct gtaggcagaa
ggcctcagaa gaaagtcatg gccactcagt 660gcccactgtg ggctttgtaa
gtcctggctc tcccgtcaag gttacccaga ggtaaaagct 720tcctgggagt
ggggccaggt gtgtttggca ctccagatag aaggcaaaat gctcagattc
780gggcctgtgc acttgtatgc aacctgtcgg tcgataccta gcatttattt
ttccctgaca 840atgaacgacc tttccctcac ccaccctaag ctcaaagagt
ttagcaaaat tctcttttaa 900ataaacagaa tgccagtaag aggttgaccc
ctaccatgga acttctggga tgctaaatac 960ttcctcatga acaaaataag
ttccttatta taagttcctt atactagcag cttcacctaa 1020agaattttct
ctccagcaat attgacttca ctggggaaaa gccaagagtg tgtggtgagt
1080gatttgttct cactcgacct ggctaggact ggctaggagc tgttttttgt
acatgaggga 1140atttgggctt tcctcagtta tctgaatgtt ttacccaagt
gccttcctgc tattgtagca 1200aagtagctca gcttccttgt ccacagggtg
aaaaaggact aatgcatttt ccatcagttt 1260tctaactatg ttagcaaaaa
cggcctcctg gtagctcaac ctcctgtacg cgtgtgtgtg 1320tgtaatacac
acacaaataa acccctctgt ttttctaaga catcttagct ggatattata
1380ggaagcactt tcataaacaa ctgtaacaaa tcgcaaagga aagagaaaca
aaagcattag 1440atttgagaca taaacaggca agagaaagtg tattaggaac
tgacagctat caaggaagtt 1500ttgtcagtta caaatgctag gaggaaattt
tgccaagaag gatggctcat gaaatatttc 1560cagtacggga agaggcaata
agatcctcta agagaatgag aaagtagggg tgtctaaatg 1620gtaaagatgg
gtgtgttgca cgtgtgttag aaggatctca gttgagtgaa ggtttgcact
1680gctacatcta agttaatgta aatatgtagc actctgacag gtctaccgtg
ttgctgaatg 1740tagtatattt ccaaagtttg caagtcttcc tgtattgtac
aaagatgctg ctgcttgata 1800atatgtatag caatccagat tagtatgtta
ttaaatttta ttttcttacc tgtattttta 1860tgctttttac ctgtcctcaa
aatattacac ccctgttgga attagattta tatttataaa 1920tggtcagaaa
tctttttaag tgtctctttt tacacatagg ttgatttttt tttcttaaga
1980gaaatgatgt attcttgaaa catttgttac tcattccagg aaacaaaaac
ccatataata 2040aaacccccac tcagagcctg ttagtcacct ctctagaaga
tggcatctca ggagaaggaa 2100tggctttgtg gaagaaggaa tcaccttttt
cttgctcaag aattatgctg acttcagccc 2160tgagcctgga tctggtcact
gagaatcatc aagtgtctag atcctccccc caaaataact 2220aatttagtag
gtgattttga ttttaaaaaa ttgacaccaa aaccctgcct gcattgtaat
2280ggaattcgaa aagaattcat gttcacagaa ctcaacgttc aggctaatat
ttacagaagg 2340gaccaaatct aaatcctggt agataactcc tgtatgcttt
atccaaagga cacccacagt 2400tttccagcat agatataacc aaggatgaat
tgattccttc aaagaactgg gaggcacgga 2460tattgcattt tttgtttaca
tccagtagcc aagacgcctc agtgagccag tcttgggcag 2520aggctgtcac
atttaggcag attggaagtt ggtatgttct aattctcact ctggactaca
2580gtgaggctga atttatcatg tcaaaaaaaa aaaaaaaaaa agacctttcc
aagtgctttc 2640tattgctcag aattgaaaga atgttttcat ttcaagttta
caagaggcat ggatggagtt 2700gtgacgttct tgacaagctg ggctaacctt
tcccgaactt gtttcccgga ggcaaggtgc 2760tcggtgaccc agcgcatctt
aaccttgggt ctcctaggct cgaggctagg gcattacgtt 2820tcgtggaacc
aaagcagcca attgcatagc aagtattttc ctgcattcca attaaatgct
2880taagaaaaag cagcatccta taaaattgtg atcataaaca tccatttccc
tcagcttttg 2940tgagtgcctt gacttacagc caacatcact gtttaactca
gtctgtttaa aaacaaactt 3000ttctggtggt tgataacaga gagttgctcc
ctgagccatc agggtcctgg gagctggaag 3060tgaaagggtt attaacattc
tacctttatg cagctgttgg ctgaccagaa taaactccct 3120gctgagttca
agctttgaat ggaatggatg caaatgatgt tgtttccatt agagcaggtg
3180ctcacagcat tctgattggc ctgagcagac cgaggctatg gctgttggga
caagcttagc 3240atcctggaca tcttgtcaaa gaacctcact cacccctctg
gcctctacag ccctcagagg 3300agagaaaacc aattctccaa caaacaggtc
tctccaacat ggtggtgctg gcaggcttag 3360gtttagaaaa tcctgactgt
taaaggcgtt tgaatacatc acattcctat gcaaatgttt 3420ttaatctcca
gtttaatgta gtttattttt cctatatgta aagtattttt atacggcttg
3480tatcatgata gtttagcaat aaaacagttg gaagcaa 3517713720DNAhomo
sapiens 71acaccttctc acaggactgg agagagaatg cggggcagct gggcagggct
cacttccagc 60cgcctgtcac agtactggga gtaagaggtg acctatttat ttttagaagg
gggcagtgat 120aataacccag ctcctagctt cattcaaggg aggcaggcgc
tttggaagtt tgtaaacacc 180aactttctga gtaagggagg agcacttttt
ttccaaaaag gaaagaacgt ctctactggg 240tttttttcct cctgatattc
agcattagag tagaaaagaa actattgttt ggccacatta 300gccgtggtta
gcaggtgctg cagcctttgc cactgttatt atttttaaag ggcagaaatg
360cctgaaggtg aagactttgg accaggcaaa agctgggaag ttatcaattc
caaaccagat 420gaaagaccca ggctcagcca ctgtattgca gaatcatgga
tgaatttcag catatttctt 480caagaaatgt ctctttttaa acagcagagc
cctggcaagt tttgtctcct ggtctgtagt 540gtgtgcacat tttttacgat
cttgggaagt tacattcctg gggttatact cagctatcta 600ctgttactgt
gtgcattttt gtgtccattg tttaaatgta atgatattgg acaaaaaatt
660tacagcaaaa ttaagtcagt tctgctgaaa ctggattttg gaattggaga
atatattaat 720cagaagaaac gtgagagatc tgaagcagac aaagaaaaaa
gtcacaaaga tgacagtgaa 780ttagactttt cagctctttg tcctaagatt
agcctcacgg ttgctgccaa agagttatct 840gtgtctgaca cagacgtctc
agaggtatcc tggactgata atgggacctt caacctttca 900gaaggataca
ctccacagac agacacttct gatgatcttg accgacccag tgaggaagtt
960ttctctagag atctttcaga ttttccatct ctagaaaatg gcatgggaac
aaatgatgaa 1020gatgaattaa gccttggttt gcccactgag ctcaagagaa
agaaggaaca gttggacagt 1080ggtcacagac caagcaaaga gacgcaatca
gcagctggtc tcacccttcc tctgaacagt 1140gaccaaacct ttcacctgat
gagcaacctg gctggggatg ttatcacagc tgcagtgact 1200gcagctatca
aagaccagtt agagggtgtg cagcaagcac tttctcaggc tgcccccatc
1260ccagaagagg acacagacac tgaagaaggt gatgactttg aactacttga
ccagtcagag 1320ctggatcaaa ttgagagtga attgggactt acacaagacc
aggaagcaga agcacagcaa 1380aataagaagt cttcaggttt cctttcaaat
ctgctgggag gccattaatc taggaatcag 1440cttgcaacag agcacaaaaa
acaccaaaaa aatttcaaac aagaaaaaaa aaaaaaaaag 1500gaaaagaaaa
aaattgaact gtaagcttta atgattactt tagatttgtt ttattttccc
1560tcctgcagtg aattaattgg atatatatca gctgacactg atagattgat
atttctgatc 1620gttatttttg tgtcataagc atggaaatga actttataca
caccactgtg ttgtcagaga 1680taaatattag gggttgtttt taaagcaaaa
agaaaaaaac aaaaaccaaa ctattaaaat 1740cctcctataa atattctttt
tctttacagt ttttcaagca tgcaaaacag tttattgtaa 1800cttactgaaa
aatattaaca attaattgtg aatacatgct gttaccagct tccttattcc
1860taatacctgg aaaatttttt tttcaacgga tagattttga tgtaaaaaag
accgaaatta 1920tcaaggtatc ttagttgaag gacttgggaa atactatcaa
aattaatttc ttaggaaaaa 1980atttaaaagt atatttaagt actctggata
gactgaaacg tttccatgtt atttctgcag 2040ttgtagactt aggcttattt
gtaaagaagc atgctccatt gactgccatc tctagtcttg 2100cagtgggtgg
tattaaccca tagaaagcaa gcagttgtgt atcacataga caatggttat
2160gatgtaaaca gattcagttg ttttgttgtt cattcgtcat atgtttgtga
tagggatgtt 2220gggagcacag ctctattctg cctgctcaga cttaagttag
acccttatct tttatattat 2280gtcatgaaaa aagtctccta aaattgtgaa
actagttctt gatgagtgat gtgatcatca 2340gcaataaaga tataataact
ctgttttctt agcctgtata gaggagagga acttgcttgg 2400ctttaaaata
tatttatttg ccatttaagt ataaatatga aatctgtttc ttattgggaa
2460gatagaatat atatattttc ctttaaactt tttaaggtca cttttaaata
accaaatttg 2520atttatggtt tttaacaaag gactaaagag ctgaaaccaa
cctagttttg tttttgtgat 2580ataaacttta agtgtcgagg gaccatgcca
gcaactacca aaaatctctt aaatcttcag 2640gtacagctgg cattttggca
gatgcataga gacatctgag accctcagaa aggaaggata 2700atccaagaat
ataggaaatc tgtgttctct tcctttcatt ttatccctta tatttctaaa
2760gactaattat aagtaatctg acattttaat gtagctactc ttatttattt
tttctttctg 2820aggtattaaa atatctggac tgagttttgc caaatgttaa
agggagaaga gttactgaag 2880actttgaaca cttgcttttt gtgattgctt
atgtcattag tgcctcatga ctgtgtttga 2940tgtcctttat tgatacaaag
tgagcctgtg ccttcattat cttgcccatt ttaatacaaa 3000tggaaacctg
gtgtttgaaa atctctgaac tgtgtgggtt ttggaggaat atacctgaat
3060tttattcaat aacagtttct ggacaggaag aaaaatacag ttacatattt
ataaaatagt 3120cgttatcagt atttttttat gtgtatgttt ctttctttaa
aacaatattc ttggatataa 3180agtagaaaag tttaaaggtc atttccattt
cttcactaag gagaaaaaaa gttaaataat 3240ccaagtaatt aaagaatata
agtcactaga tgaccttaca ggaagacgaa ctcaagggct 3300gataatctgt
ggtggtatga acaataaatc tagaataaaa tgttaataac tacaaattaa
3360aaggggtgtg aggatgggag gaagttggta gggtagaaaa atgtgctatt
accactattg 3420aggagacatg ccagctctct agggacagca gcattataac
tatgtatgaa ttttaatatt 3480atttgtatat gactgtatga ctacaaattt
acacaataca ataatgggac tttctcacaa 3540ctattaattc aaacaaacac
aaggatgttg aaggttcttg tttgtgtata tgtgtgtttt 3600ggtggtgggg
ggtcactgtt tctggtttta aaagatgaag gagcagatac atttcatatg
3660attgatccag tgtagtagag gactacatgt cctttactat gagaatataa
atagcaatat 372072356PRThomo sapiens 72Met Pro Glu Gly Glu Asp Phe
Gly Pro Gly Lys Ser Trp Glu Val Ile1 5 10 15Asn Ser Lys Pro Asp Glu
Arg Pro Arg Leu Ser His Cys Ile Ala Glu20 25 30Ser Trp Met Asn Phe
Ser Ile Phe Leu Gln Glu Met Ser Leu Phe Lys35 40 45Gln Gln Ser Pro
Gly Lys Phe Cys Leu Leu Val Cys Ser Val Cys Thr50 55 60Phe Phe Thr
Ile Leu Gly Ser Tyr Ile Pro Gly Val Ile Leu Ser Tyr65 70 75 80Leu
Leu Leu Leu Cys Ala Phe Leu Cys Pro Leu Phe Lys Cys Asn Asp85 90
95Ile Gly Gln Lys Ile Tyr Ser Lys Ile Lys Ser Val Leu Leu Lys
Leu100 105 110Asp Phe Gly Ile Gly Glu Tyr Ile Asn Gln Lys Lys Arg
Glu Arg Ser115 120 125Glu Ala Asp Lys Glu Lys Ser His Lys Asp Asp
Ser Glu Leu Asp Phe130 135 140Ser Ala Leu Cys Pro Lys Ile Ser Leu
Thr Val Ala Ala Lys Glu Leu145 150 155 160Ser Val Ser Asp Thr Asp
Val Ser Glu Val Ser Trp Thr Asp Asn Gly165 170 175Thr Phe Asn Leu
Ser Glu Gly Tyr Thr Pro Gln Thr Asp Thr Ser Asp180 185 190Asp Leu
Asp Arg Pro Ser Glu Glu Val Phe Ser Arg Asp Leu Ser Asp195 200
205Phe Pro Ser Leu Glu Asn Gly Met Gly Thr Asn Asp Glu Asp Glu
Leu210 215 220Ser Leu Gly Leu Pro Thr Glu Leu Lys Arg Lys Lys Glu
Gln Leu Asp225 230 235 240Ser Gly His Arg Pro Ser Lys Glu Thr Gln
Ser Ala Ala Gly Leu Thr245 250 255Leu Pro Leu Asn Ser Asp Gln Thr
Phe His Leu Met Ser Asn Leu Ala260 265 270Gly Asp Val Ile Thr Ala
Ala Val Thr Ala Ala Ile Lys Asp Gln Leu275 280 285Glu Gly Val Gln
Gln Ala Leu Ser Gln Ala Ala Pro Ile Pro Glu Glu290 295 300Asp Thr
Asp Thr Glu Glu Gly Asp Asp Phe Glu Leu Leu Asp Gln Ser305 310 315
320Glu Leu Asp Gln Ile Glu Ser Glu Leu Gly Leu Thr Gln Asp Gln
Glu325 330 335Ala Glu Ala Gln Gln Asn Lys Lys Ser Ser Gly Phe Leu
Ser Asn Leu340 345 350Leu Gly Gly His355734052DNAhomo sapiens
73gtaagtattt aaatacaatt atttttttct ctcaatggta tagcatattc ctatgcttga
60gaagtatagg tctactgaaa aaccattgta aatggacgtt acaggtatgc tgtatttttg
120aaggtatttt gttgtattaa gtttgatgaa gctaaaatta gggaactctg
aacagatttg 180caggaaaaaa tgttttaaag gctttaaaac attagggagg
cagtctaggg tgataacgaa 240caggggttaa gtattaaata cacgaagtta
catttttgtt catgtttcat tgtccagaaa 300gcagcaggaa actattcagt
tgtgatcaag caggaaaaaa gaaacaccaa cagttgccag 360tgtttttgct
ttttagctta aaagcatagt gaagatgctt gaggaagact ttgctacctg
420gggtgtgtag acagacagac tgagagctat cagcatttga aggcccagcc
cttgactctg 480agacacattt gaattttttc tttcccatca aatggcatta
acaagattgg gcaaagatga 540gtccctcaaa tttctgtgtt ttttgtttgt
ttgtttgttt gttttttctt tgggaactga 600agtcagaggc acgaacacta
actcttagca tttttctgta gactttttct tctggccctt 660gtccctgcca
gcaaaacgcc ccttttctga tcattcgtgc gcagagggcc tcccagtaat
720gccacgctct ccatgctaga gagccttctc tttcctctga ggtttgaact
gatgttctgt 780gtcttcacac cctggcatga cagttacgtg tggtcagccc
gctccccagg cccgtccctg 840ccgccgccag gtgtgggctc taggcaggcc
gacaaggtta cacctcccag agcttgtgat 900cttcattttc tgacagtcaa
agtgtgaagg aacccagact tccccgagcc acggtgttca 960gtcagcccac
aggaatatgc aagacccatc tccaaaagtt tgtctttgat tttttccaag
1020cccttagccc cataagcttt gaatcctgta gttacagtgg cataaaggac
tgacaaaacc 1080tggataagga aaaacctttt ttttctatga attttttttg
ttttttaggg gaaagggatt 1140ctaagaatgt catttaatgt actttgcatc
atgtctctag aaatatcttt gtccatagtg 1200gtggtggagt ctctctctct
ctctctcttt ttgtttgctt ctgttttctt tcttgtcttc 1260attctttctt
ttctttttta tttctggtag caggcctcca tagaacaaat ctaaaacaca
1320accaccatag taatgtaagg agagcttcag tggcacctca aaacccaccc
ttcgagatct 1380gtccaaagac agtctcagaa agctgcactg cccaccggct
cagctttcat tcaaaaaggc 1440ttccaaggcc aattctgtct tgaagtcaat
gcatgtattt actgtttgac agtaaacccg 1500ctctgccttc tccacgtcca
aggctgtgca ttcgtctaat tagcgtcgtg tatgttttcc 1560ttttattttt
tccaataaaa aagcagtggg atgaaaattg ctttgatata tagcaggtaa
1620cattgaagct attccatagc acttaactgt agtgaatact gtgtcaccaa
ttttgaaatc 1680aatttaatgt ttaatgcaaa tccattacat ggtgctatta
taggctgaca aaatgattta 1740cacaaatgtg acaacttggg ctcaattcac
tctgctttcc aacagtgtaa atgcatagca 1800gtgtttatct gcatgagaac
tatgcactaa tctatctgaa gaaaaaaact atatcaactt 1860tggtatctac
tttccgttta cttcaatcct tgcctttttg gtcattgtta taatgccagc
1920tttaggacag aaagaattat aagaaaacca gcataatacc tgatatatta
aaatgtagtg 1980cctgtgaaat ctgtattata ttgctcttct gaagtaagat
ttttctacac cggtagcctt 2040cgctgtctgt cagtcaggac cttctggtat
aggtgatgta aaataaccgt acaatattaa 2100tgcatgcgat tccataatgc
ttagtgaact gtatgaatat tactcaaagt tatgttagtc 2160tttttttccg
acttggttct tgtcagctag gtttaaaggt atttcactga gaacgcaaat
2220tctgtctttt cttgatttcg gctgttttca gtattttgga ggtatacatt
tacttaaatt 2280cagtattact cgtgttttgt ttttgttttt gttttttgtt
ttctttttcc taggggacaa 2340gcatgggtgt ttgatttcag aaatcagtac
ctggcgagat ttttgtctca aaacgactat 2400ttgaatttca agaactgtgc
tgcgaagaca ctctgagaac atttgcaagt caggggcatt 2460ttccttgacc
cttgactgat gctatgcgga gactgataca ttttcttaat ggacaatgtt
2520caagccaggt acccatgctt gatctgtctt cacaccagac ctcctcatat
taaaaggaaa 2580aataagaaaa aaaatgtaag aaatcacatg gctatttagt
ttcatgcaca gttgcaatat 2640tttcttcaaa aataaaactc tgtacaaact
ttgggcccga ttcataagaa aaagaagttt 2700gctattaaca cgggattttt
ttaatatact ttttttggtc taaatttgaa attacttgct 2760tcccaaatta
aataaatttc atctcatttt tttccctaaa ccagcaccca tctgcctttt
2820attccccaaa gagttacctt tcccagatta gggggatggt atgtggggag
cagatagcgg 2880aaatgcttag aaagataagg gggaccaccc acagctggtc
gtgagaacag ggagacagtg 2940tgtgggggtg ggacctcatc tgtgtgcctg
gtatcctgag ttttacatgt agatgcattc 3000gcctatttga ttcagaaaaa
taaactttcc caaaatgtgt ctgaaccaca agagcataca 3060gtggaagtgc
tacctctaat ctaaccagag caccttcatg gtggaagaca cccaccaggt
3120catacaatgt gaacttttgt atctctgcag tggtttcaag gacaaatagt
gtccaatgta 3180ttgggccatt tttcctgctg tttttatact caacttctca
aaatgaaaaa agcttttatt 3240tttcctttga cttatttgtg ttgttcttat
tttttaaatt tttatttttt gataatagtc 3300tgtaagttag cctttttggg
tttttttttt ttttttttgg cttttttttt tgtttgtttt 3360tttttctttt
gacattgcaa ccgaaggtca taaggccgct agctccgctg ggacagaggc
3420ttgagagaac taacggctcg gtgccttctc cctggtctca gaccatcgtc
tctgcactgc 3480gaaggcattt ggtagcctcg ccactgagat actaactaga
cctagactag gagctttatc 3540aggttctagg aggtccttta ggaagactct
caaaggcaaa tccctgatcc cccgccccac 3600ccttagccct gccctctcac
cagagcaaaa ttcactgggg acttttccca ccacacatgg 3660aaatctgtcc
actcggaata cctctgtttt ccatttcaaa ttgtaggggg aggggatgga
3720acacttccag tgatggtaag agatctgtta tgaaacgaaa caccccccgt
gttaataact 3780tggtctgaaa tctgttttta tgagccgggc cccctgtgcc
tctagtatac ttgtattgac 3840tctcatagtt acccttttag ttttactgtg
ttctgtgaaa atttgtaatt ggttgagaat 3900cactgtgggc gtccattctt
attcaactaa atctccacag gttttttgag ctggtgtgga 3960ttagtttaac
tcttgtattc aaccattagt gctaccacct tctcacatta caatacaatt
4020actggaagca agtactgcat ttcctatgca ac 4052742572DNAhomo sapiens
74ccgctttctc cgcgcggtgc ctgcagggct cccagcgagt ggcagcttgg gaggggccgc
60ccgggcggtc agactggcac ctgagcggcc accgcgtccc ggccaggcgg gcagaccgac
120cccctcctca cctcgcgcgc ggctgacgca ggcagggcgc ccggcccctc
ctggggacca 180tcaggtgccg gctgggggct gtaggcaccg gacggaagca
ggcggtgtga ggaccgacga 240cgcgggcatg gcgggggcgg cctgcgagcc
ggtggccagg ccgagcctga cctccatctc 300gtctggggag cttcgcagcc
tgtggacctg cgactgcgag ctggccctgc tgccgctggc 360tcagctgctg
cgcctgcagc ccggtgcctt ccagctgagc ggcgaccagc tcgtggtggc
420caggcccggg gagccggcgg cggcgcgggg gggcttcaac gtcttcggtg
acggcctcgt 480gcgcctcgac gggcagctct accgcctcag cagctacatc
aagaggtatg tggaactgac 540caactactgt gattataaag actacaggga
aactatattg agcaaaccaa tgttgttctt 600tattaatgta cagaccaaaa
aagacacctc aaaagaaagg acgtacgcgt ttcttgtaaa 660cacgaggcac
cccaagataa gaagacagat agagcaaggg atggacatgg tcatctcctc
720agtgattgga
gaaagttacc ggcttcagtc aatgcaatgt tcctctctct ttcagtttga
780ttttcaagag gcagtgaaga atttcttccc cccaggaaat gaagtggtta
atggagaaaa 840tttaagcttt gcatatgaat tcaaagctga tgcattattt
gatttcttct attggtttgg 900gctcagtaat tccgttgtaa aagtaaatgg
aaaagttctg aatttgtcaa gtacaagtcc 960agaaaagaag gagacgatta
agttatttct ggaaaaaatg agtgagcctt taatccgaag 1020gagcagtttc
tctgaccgaa agttcagtgt aacttccaga ggttcaatag atgatgtttt
1080taactgcaat ctgtcaccca gatcatctct gacagagcct cttttggcag
aattaccatt 1140tccaagtgtt ctggaatctg aagagacacc caaccaattt
atctgattga actgaacatt 1200gtagcagttg ctcccgcact ccaggcctgt
gctagactat aggctggggg gagggtagga 1260ggtgggaggc agatacttcc
acctgcgtgt caatctccgg ctcctccatg gcttctatgg 1320aggactcctc
tcttctgctt ctgtggatgt gatgccctgg caggcccagg gcagctgatt
1380cccctaaaac ttatgattac caggatggaa aggccttggt cccatggcac
tgggtggggc 1440tgggggatat tctctacttt gaacacttct ccaaagaggc
agaagggcca cagagttctg 1500ccaccctgaa catttttctc agttccctgg
gagtttttgt ggcagccttt gtgggagtgg 1560tctgactggc tgttgaccta
gcatgcttca taaatcaggg tttggccctc tgcttggagc 1620atccaacccc
ttgaactcaa acctgtcgag caaggggtta agagttctgt tctcttgcca
1680acctggctgg gcaaaagcct gtgccatctt tcactgggag gcaaatatgt
ttttcatcct 1740gccatatgac acctatgaga aacgttcaca gtgaggagta
gccaggttgc taggacagta 1800accctgccac acactgcctg aaatcggaac
tcccttggcc tccctcttaa ctaagtgacc 1860catgtagaag gaagccagga
gatatggtac cgaacaatga caggggaagg gtattggaca 1920cggcagcgtc
ctccttattg aaaacacatt atgtcagttg ggaattttaa ataagctttt
1980agcaaaccta acactaaaag caaaatagaa gaaagctata ccattaccat
aatacatttt 2040tcatctcatg gctacaatgg aattcttgaa aaggaaaaaa
aaatcctatc tacatataaa 2100aacctgcatg aatgaatcac tacatatgct
tataatgagg aagagttatg ggtcctgagt 2160gtaatttttt atcctttctt
aaaaagtttc tgtattatgc attttgataa cactactgat 2220gatccttcca
cttatatttg aaatgttatg taccacattt gcacaattaa aacttttctt
2280agcattcaac ctagaattga ttaaatttat gactgaggct tcatgtgagc
tttccattgt 2340ggtttgtggg tgttgtattt gccttgtaac ttactgaatt
acaataagaa ttgtgggttt 2400tcatagccac tttctcaaga agcgcctttt
gaagaacaag gctatgaagt atttgaagaa 2460aggaaataaa atttgatact
gatctttcag aaaagagaag gggaatgcta cttaataaca 2520gaagatgtta
aacatttatt attacactca ataaaaaatg aagagtatta ac 257275312PRThomo
sapiens 75Met Ala Gly Ala Ala Cys Glu Pro Val Ala Arg Pro Ser Leu
Thr Ser1 5 10 15Ile Ser Ser Gly Glu Leu Arg Ser Leu Trp Thr Cys Asp
Cys Glu Leu20 25 30Ala Leu Leu Pro Leu Ala Gln Leu Leu Arg Leu Gln
Pro Gly Ala Phe35 40 45Gln Leu Ser Gly Asp Gln Leu Val Val Ala Arg
Pro Gly Glu Pro Ala50 55 60Ala Ala Arg Gly Gly Phe Asn Val Phe Gly
Asp Gly Leu Val Arg Leu65 70 75 80Asp Gly Gln Leu Tyr Arg Leu Ser
Ser Tyr Ile Lys Arg Tyr Val Glu85 90 95Leu Thr Asn Tyr Cys Asp Tyr
Lys Asp Tyr Arg Glu Thr Ile Leu Ser100 105 110Lys Pro Met Leu Phe
Phe Ile Asn Val Gln Thr Lys Lys Asp Thr Ser115 120 125Lys Glu Arg
Thr Tyr Ala Phe Leu Val Asn Thr Arg His Pro Lys Ile130 135 140Arg
Arg Gln Ile Glu Gln Gly Met Asp Met Val Ile Ser Ser Val Ile145 150
155 160Gly Glu Ser Tyr Arg Leu Gln Ser Met Gln Cys Ser Ser Leu Phe
Gln165 170 175Phe Asp Phe Gln Glu Ala Val Lys Asn Phe Phe Pro Pro
Gly Asn Glu180 185 190Val Val Asn Gly Glu Asn Leu Ser Phe Ala Tyr
Glu Phe Lys Ala Asp195 200 205Ala Leu Phe Asp Phe Phe Tyr Trp Phe
Gly Leu Ser Asn Ser Val Val210 215 220Lys Val Asn Gly Lys Val Leu
Asn Leu Ser Ser Thr Ser Pro Glu Lys225 230 235 240Lys Glu Thr Ile
Lys Leu Phe Leu Glu Lys Met Ser Glu Pro Leu Ile245 250 255Arg Arg
Ser Ser Phe Ser Asp Arg Lys Phe Ser Val Thr Ser Arg Gly260 265
270Ser Ile Asp Asp Val Phe Asn Cys Asn Leu Ser Pro Arg Ser Ser
Leu275 280 285Thr Glu Pro Leu Leu Ala Glu Leu Pro Phe Pro Ser Val
Leu Glu Ser290 295 300Glu Glu Thr Pro Asn Gln Phe Ile305
310761010DNAhomo sapiens 76caggcggcga ggagagcggt gccttgcagg
gatgctgcgg gcgggagcac caaccgggga 60cttaccccgg gcgggagaag tccacaccgg
gaccaccatc atggcagtgg agtttgacgg 120gggcattgtg atgggttctg
attcccgagt gtctgcaggc gaggcggtgg tgaaccgagt 180gtttgacaag
ctgtccccgc tgcacgagcg catctactgt gcactctctg gttcagctgc
240tgatgcccaa gccgtggccg acatggccgc ctaccagctg gagctccatg
ggatagaact 300ggaggaacct ccacttgttt tggctgctgc aaatgtggtg
agaaatatca gctataaata 360tcgagaggac ttgtctgcac atctcatggt
agctggctgg gaccaacgtg aaggaggtca 420ggtatatgga accctgggag
gaatgctgac tcgacagcct tttgccattg gtggctccgg 480cagcaccttt
atctatggtt atgtggatgc agcatataag ccaggcatgt ctcccgagga
540gtgcaggcgc ttcaccacag acgctattgc tctggccatg agccgggatg
gctcaagcgg 600gggtgtcatc tacctggtca ctattacagc tgccggtgtg
gaccatcgag tcatcttggg 660caatgaactg ccaaaattct atgatgagtg
aaccttcccc agacttctct ttcttatttt 720gtaataaact ctctaggacc
aaaacctggt atggtcattg ggaaatgagt gctcagggag 780atggagctta
ggggaggtgg gtgcttccct cctagatgtc agcatacact ctttcttctt
840ttgtcccagg tctaaaacat ctttcctaga gaaaacaaaa gggactaaac
tagaaatata 900aagagcccta tacatgacag gtgatcacgt actgaatgat
tttgaagtag tacaaacaat 960aaaaattctc attccgcatc atcatgcggt
ccatgatgat gaggccgcaa 101077219PRThomo sapiens 77Met Leu Arg Ala
Gly Ala Pro Thr Gly Asp Leu Pro Arg Ala Gly Glu1 5 10 15Val His Thr
Gly Thr Thr Ile Met Ala Val Glu Phe Asp Gly Gly Val20 25 30Val Met
Gly Ser Asp Ser Arg Val Ser Ala Gly Glu Ala Val Val Asn35 40 45Arg
Val Phe Asp Lys Leu Ser Pro Leu His Glu His Ile Tyr Cys Ala50 55
60Leu Ser Gly Ser Ala Ala Asp Ala Gln Ala Val Ala Asp Met Ala Ala65
70 75 80Tyr Gln Leu Glu Leu His Gly Ile Glu Leu Glu Glu Pro Pro Leu
Val85 90 95Leu Ala Ala Ala Asn Val Val Arg Asn Ile Ser Tyr Lys Tyr
Arg Glu100 105 110Asp Leu Ser Ala His Leu Met Val Ala Gly Trp Asp
Gln Arg Glu Gly115 120 125Gly Gln Val Tyr Gly Thr Leu Gly Gly Met
Leu Thr Arg Gln Pro Phe130 135 140Ala Ile Gly Gly Ser Gly Ser Thr
Phe Ile Tyr Gly Tyr Val Asp Ala145 150 155 160Ala Tyr Lys Pro Gly
Met Ser Pro Glu Glu Cys Arg Arg Phe Thr Thr165 170 175Asp Ala Ile
Ala Leu Ala Met Ser Arg Asp Gly Ser Ser Gly Gly Val180 185 190Ile
Tyr Leu Val Thr Ile Thr Ala Ala Gly Val Asp His Arg Val Ile195 200
205Leu Gly Asn Glu Leu Pro Lys Phe Tyr Asp Glu210 21578604DNAhomo
sapiens 78ccacgcgtcc gcgctgcgcc acatcccacc ggcccttaca ctgtggtgtc
cagcagcatc 60cggcttcatg gggggacttg aaccctgcag caggctcctg ctcctgcctc
tcctgctggc 120tgtaagtggt ctccgtcctg tccaggccca ggcccagagc
gattgcagtt gctctacggt 180gagcccgggc gtgctggcag ggatcgtgat
gggagacctg gtgctgacag tgctcattgc 240cctggccgtg tacttcctgg
gccggctggt ccctcggggg cgaggggctg cggaggcagc 300gacccggaaa
cagcgtatca ctgagaccga gtcgccttat caggagctcc agggtcagag
360gtcggatgtc tacagcgacc tcaacacaca gaggccgtat tacaaatgag
cccgaatcat 420gacagtcagc aacatgatac ctggatccag ccattcctga
agcccaccct gcacctcatt 480ccaactccta ccgcgataca gacccacaga
gtgccatccc tgagagacca gaccgctccc 540caatactctc ctaaaataaa
catgaagcac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 600aaaa 60479113PRThomo
sapiens 79Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro
Leu Leu1 5 10 15Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala
Gln Ser Asp20 25 30Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala
Gly Ile Val Met35 40 45Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu
Ala Val Tyr Phe Leu50 55 60Gly Arg Leu Val Pro Arg Gly Arg Gly Ala
Ala Glu Ala Ala Thr Arg65 70 75 80Lys Gln Arg Ile Thr Glu Thr Glu
Ser Pro Tyr Gln Glu Leu Gln Gly85 90 95Gln Arg Ser Asp Val Tyr Ser
Asp Leu Asn Thr Gln Arg Pro Tyr Tyr100 105 110Lys801610DNAhomo
sapiens 80cccagagcag cgctcgccac ctccccccgg cctgggcagc gctcgcccgg
ggagtccagc 60ggtgtcctgt ggagctgccg ccatggcccc gcggcgggcg cgcggctgcc
ggaccctcgg 120tctcccggcg ctgctactgc tgctgctgct ccggccgccg
gcgacgcggg gcatcacgtg 180ccctcccccc atgtccgtgg aacacgcaga
catctgggtc aagagctaca gcttgtactc 240cagggagcgg tacatttgta
actctggttt caagcgtaaa gccggcacgt ccagcctgac 300ggagtgcgtg
ttgaacaagg ccacgaatgt cgcccactgg acaaccccca gtctcaaatg
360cattagagac cctgccctgg ttcaccaaag gccagcgcca ccctccacag
taacgacggc 420aggggtgacc ccacagccag agagcctctc cccttctgga
aaagagcccg cagcttcatc 480tcccagctca aacaacacag cggccacaac
agcagctatt gtcccgggct cccagctgat 540gccttcaaaa tcaccttcca
caggaaccac agagataagc agtcatgagt cctcccacgg 600caccccctct
cagacaacag ccaagaactg ggaactcaca gcatccgcct cccaccagcc
660gccaggtgtg tatccacagg gccacagcga caccactgtg gctatctcca
cgtccactgt 720cctgctgtgt gggctgagcg ctgtgtctct cctggcatgc
tacctcaagt caaggcaaac 780tcccccgctg gccagcgttg aaatggaagc
catggaggct ctgccggtga cttgggggac 840cagcagcaga gatgaagact
tggaaaactg ctctcaccac ctatgaaact cggggaaacc 900agcccagcta
agtccggagt gaaggagcct ctctgcttta gctaaagacg actgagaaga
960ggtgcaagga agcgggctcc aggagcaagc tcaccaggcc tctcagaagt
cccagcagga 1020tctcacggac tgccgggtcg gcgcctcctg cgcgagggag
caggttctcc gcattcccat 1080gggcaccacc tgcctgcctg tcgtgccttg
gacccagggc ccagcttccc aggagagacc 1140aaaggcttct gagcaggatt
tttatttcat tacagtgtga gctgcctgga atacatgtgg 1200taatgaaata
aaaaccctgc cccgaatctt ccgtccctca tcctaacttg cagttcacag
1260agaaaagtga catacccaaa gctctctgtc aattacaagg cttctcctgg
cgtgggagac 1320gtctacaggg aagacaccag cgtttgggct tctaaccacc
ctgtctccag ctgctctgca 1380cacatggaca gggacctggg aaaggtggga
gagatgctga gcccagcgaa tcctctccat 1440tgaaggattc aggaagaaga
aaactcaact cagtgccatt ttacgaatat atgcgtttat 1500atttatactt
ccttgtctat tatatctata cattatatat tatttgtatt ttgacattgt
1560accttgtata aacaaaataa aacatctatt ttcaatattt ttaaaatgca
161081267PRThomo sapiens 81Met Ala Pro Arg Arg Ala Arg Gly Cys Arg
Thr Leu Gly Leu Pro Ala1 5 10 15Leu Leu Leu Leu Leu Leu Leu Arg Pro
Pro Ala Thr Arg Gly Ile Thr20 25 30Cys Pro Pro Pro Met Ser Val Glu
His Ala Asp Ile Trp Val Lys Ser35 40 45Tyr Ser Leu Tyr Ser Arg Glu
Arg Tyr Ile Cys Asn Ser Gly Phe Lys50 55 60Arg Lys Ala Gly Thr Ser
Ser Leu Thr Glu Cys Val Leu Asn Lys Ala65 70 75 80Thr Asn Val Ala
His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp85 90 95Pro Ala Leu
Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr100 105 110Ala
Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu115 120
125Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr
Ala130 135 140Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser
Pro Ser Thr145 150 155 160Gly Thr Thr Glu Ile Ser Ser His Glu Ser
Ser His Gly Thr Pro Ser165 170 175Gln Thr Thr Ala Lys Asn Trp Glu
Leu Thr Ala Ser Ala Ser His Gln180 185 190Pro Pro Gly Val Tyr Pro
Gln Gly His Ser Asp Thr Thr Val Ala Ile195 200 205Ser Thr Ser Thr
Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu210 215 220Ala Cys
Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu225 230 235
240Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser
Arg245 250 255Asp Glu Asp Leu Glu Asn Cys Ser His His Leu260
2658224DNAArtificial SequenceSynthetic primer 82ggaacaggaa
agacttctca agca 248323DNAArtificial SequenceSynthetic primer
83cttgacgtag ttgcaagctc tca 238421DNAArtificial SequenceSynthetic
primer 84gctgaagcaa ggtagcgatg a 218520DNAArtificial
SequenceSynthetic primer 85cctcgttgct gagtgttgga
208628DNAArtificial SequenceSynthetic primer 86tcagactgaa
gagctactgt aatgatca 288726DNAArtificial SequenceSynthetic primer
87caacaatcaa gacattcttt ccagtt 268822DNAArtificial
SequenceSynthetic primer 88tgctttcact tgtgcctctt tc
228921DNAArtificial SequenceSynthetic primer 89caggctctca
cagagacgga a 219017DNAArtificial SequenceSynthetic primer
90agccgagcca catcgct 179119DNAArtificial SequenceSynthetic primer
91gtgaccaggc gcccaatac 19
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