Inducing Cellular Immune Responses to Hepatitis B Virus Using Peptide and Nucleic Acid Compositions

Abstract

This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS

[0001] This application is a divisional of U.S. application Ser. No. 10/654,601, filed Sep. 4, 2003, which is a divisional of U.S. application Ser. No. 09/239,043, filed Jan. 27, 1999, which is herein incorporated by reference; the current application is also a continuation-in-part of U.S. application Ser. No. 09/350,401, filed Jul. 8, 1999, which is a continuation-in-part of U.S. application Ser. No. 09/239,043, filed Jan. 27, 1999, now U.S. Pat. No. 6,689,363, which is herein incorporated by reference; and is a continuation-in-part of U.S. application Ser. No. 08/347,610, filed Dec. 1, 1994, abandoned, which is herein incorporated by reference; and is a continuation-in-part of U.S. application Ser. No. 08/344,824, filed Nov. 23, 1994, abandoned, which is herein incorporated by reference; and is a continuation-in-part of U.S. application Ser. No. 08/205,713, filed Mar. 4, 1994, abandoned, which is herein incorporated by reference; and is a continuation-in-part of U.S. application Ser. No. 09/189,702, filed Nov. 10, 1998, which is herein incorporated by reference; and is a continuation-in-part of U.S. application Ser. No. 08/820,360, filed Mar. 12, 1997, abandoned, which is herein incorporated by reference; and is a continuation-in-part of U.S. application Ser. No. 08/197,484, filed Feb. 16, 1994, now U.S. Pat. No. 6,419,931, which is herein incorporated by reference; which is a continuation-in-part of U.S. application Ser. No. 07/935,811, filed Aug. 26, 1992, abandoned, which is herein incorporated by reference; which is a continuation-in-part of U.S. application Ser. No. 07/874,491, filed Apr. 27, 1992, abandoned, which is herein incorporated by reference; which is a continuation-in-part of U.S. application Ser. No. 07/827,682, filed Jan. 29, 1992, abandoned, which is herein incorporated by reference; said U.S. application Ser. No. 08/347,610 (abandoned) is a continuation-in-part of U.S. application Ser. No. 08/159,339, filed Nov. 29, 1993, now U.S. Pat. No. 6,037,135, which is herein incorporated by reference; which is a continuation-in-part of U.S. application Ser. No. 08/103,396, filed Aug. 6, 1993, abandoned, which is herein incorporated by reference; which is a continuation-in-part of U.S. application Ser. No. 08/027,746, filed Mar. 5, 1993, abandoned, which is herein incorporated by reference; which is a continuation-in-part of U.S. application Ser. No. 07/926,666, filed Aug. 7, 1992, abandoned, which is herein incorporated by reference; said U.S. application Ser. No. 08/344,824 (abandoned) is a continuation-in-part of U.S. application Ser. No. 08/278,634, filed Jul. 21, 1994, abandoned, which is herein incorporated by reference; said U.S. application Ser. No. 08/205,713 (abandoned) is a continuation-in-part of U.S. application Ser. No. 08/159,184, filed Nov. 29, 1993, abandoned, which is herein incorporated by reference; which is a continuation-in-part of U.S. application Ser. No. 08/073,205, filed Jun. 4, 1993, abandoned, which is herein incorporated by reference; which is a continuation-in-part of U.S. application Ser. No. 08/027,146, filed Mar. 5, 1993, abandoned, which is herein incorporated by reference; said U.S. application Ser. No. 09/189,702 is a continuation-in-part of said U.S. application Ser. No. 08/205,713 (abandoned); said U.S. application Ser. No. 08/820,360 (abandoned) claims the benefit of U.S. Provisional Application No. 60/013,363, filed Mar. 13, 1996, abandoned, which is herein incorporated by reference; the present application is also a continuation-in-part of U.S. application Ser. No. 08/978,291, filed Nov. 25, 1997, abandoned; which is a continuation of U.S. application Ser. No. 08/461,603, filed Jun. 5, 1995, abandoned, which is herein incorporated by reference; which is a continuation of said U.S. application Ser. No. 07/935,811 (abandoned).

[0002] The present application is also related to abandoned U.S. Ser. No. 08/464,234, U.S. Ser. No. 08/464,496, now U.S. Pat. No. 6,322,789, abandoned U.S. Ser. No. 08/464,031, abandoned U.S. Ser. No. 08/464,433, and abandoned U.S. Ser. No. 08/461,603, which is a continuation of abandoned U.S. Ser. No. 07/935,811, which is a CIP of abandoned U.S. Ser. No. 07/874,491, which is a CIP of abandoned U.S. Ser. No. 07/827,682, which is a CIP of abandoned 07/749,568. The present application is also related to U.S. Ser. No. 09/226,775, filed Jan. 6, 1999, which is a CIP of abandoned U.S. Ser. No. 08/815,396, which is a CIP of abandoned U.S. Ser. No. 60/013,113. Furthermore, the present application is related to abandoned U.S. Ser. No. 09/017,735, which is a CIP of abandoned U.S. Ser. No. 08/589,108; abandoned U.S. Ser. No. 08/753,622, abandoned U.S. Ser. No. 08/822,382, abandoned U.S. Ser. No. 60/013,980, abandoned U.S. Ser. No. 08/454,033, abandoned U.S. Ser. No. 09/116,424, abandoned U.S. Ser. No. 08/205,713, and abandoned U.S. Ser. No. 08/349,177, which is a CIP of abandoned U.S. Ser. No. 08/159,184, which is a CIP of abandoned U.S. Ser. No. 08/073,205, which is a CIP of abandoned U.S. Ser. No. 08/027,146. The present application is also related to abandoned U.S. Ser. No. 09/017,524, abandoned U.S. Ser. No. 08/821,739, abandoned U.S. Ser. No. 60/013,833, abandoned U.S. Ser. No. 08/758,409, abandoned U.S. Ser. No. 08/589,107, abandoned U.S. Ser. No. 08/451,913, U.S. Ser. No. 08/186,266, now U.S. Pat. No. 5,662,907, abandoned U.S. Ser. No. 09/116,061, and abandoned U.S. Ser. No. 08/347,610, which is a CIP of U.S. Ser. No. 08/159,339, now U.S. Pat. No. 6,037,135, which is a CIP of abandoned U.S. Ser. No. 08/103,396, which is a CIP of abandoned U.S. Ser. No. 08/027,746, which is a CIP of abandoned U.S. Ser. No. 07/926,666. The present application is also related to abandoned U.S. Ser. No. 09/017,743, abandoned U.S. Ser. No. 08/753,615; U.S. Ser. No. abandoned 08/590,298, abandoned U.S. Ser. No. 09/115,400, and abandoned U.S. Ser. No. 08/452,843, which is a CIP of abandoned U.S. Ser. No. 08/344,824, which is a CIP of abandoned U.S. Ser. No. 08/278,634. The present application is also related to provisional U.S. Ser. No. 60/087,192 and U.S. Ser. No. 09/009,953, now U.S. Pat. No. 6,413,517, which is a CIP of abandoned U.S. Ser. No. 60/036,713 and abandoned U.S. Ser. No. 60/037,432. In addition, the present application is related to abandoned U.S. Ser. No. 09/098,584 and to U.S. Prov. Appl. No. 60/117,486, filed Jan. 27, 1999, now inactive. All of the above applications are incorporated herein by reference.

REFERENCE TO SEQUENCE LISTING SUBMITTED ELECTRONICALLY VIA EFS-WEB

[0004] The content of the electronically submitted sequence listing (Name: sequence listing ascii.txt, Size: 524,288 bytes; and Date of Creation: Jul. 31, 2009) filed herewith the application is incorporated by reference in its entirety.

INDEX

I. Background of the Invention

II. Summary of the Invention

III. Brief Description of the Figures

IV. Detailed Description of the Invention

[0005] A. Definitions [0006] B. Stimulation of CTL and HTL responses against HBV [0007] C. Immune Response Stimulating Peptides [0008] 1. Binding Affinity of the Peptides for HLA Molecules [0009] 2. Peptide Binding Motifs and Supermotifs [0010] a) HLA-A1 supermotif [0011] b) HLA-A2 supermotif [0012] c) HLA-A3 supermotif [0013] d) HLA-A24 supermotif [0014] e) HLA-B7 supermotif [0015] f) HLA-B27 supermotif [0016] g) HLA-B44 supermotif [0017] h) HLA-B58 supermotif [0018] i) HLA-B62 supermotif [0019] j) HLA-A1 motif [0020] k) HLA-A3 motif [0021] l) HLA-A11 motif [0022] m) HLA-A24 motif [0023] n) HLA-A2.1 motif [0024] o) HLA-DR-1-4-7 supermotif [0025] p) HLA-DR3 motifs [0026] 3. Enhancing Population Coverage of the Vaccine [0027] D. Immune Response Stimulating Peptide Analogs [0028] E. Computer Screening of Protein Sequences from Disease-Related Antigens for Supermotif or Motif Containing Peptides [0029] F. Assays to Detect T-Cell Responses [0030] G. Preparation of Peptides [0031] H. Use of Peptide Epitopes for Evaluating Immune Responses [0032] I. Vaccine Compositions [0033] 1. Minigene Vaccines [0034] 2. Combinations with Helper Peptides [0035] J. Administration of Vaccines for Therapeutic or Prophylactic Purposes [0036] K. Kits

V. Examples

I. BACKGROUND OF THE INVENTION

[0037] Chronic infection by hepatitis B virus (HBV) affects at least 5% of the world's population and is a major cause of cirrhosis and hepatocellular carcinoma (Hoofnagle, J., N. Engl. J. Med. 323:337, 1990; Fields, B. and Knipe, D., In: Fields Virology 2:2137, 1990). The World Health Organization lists hepatitis B as a leading cause of death worldwide, close behind chronic pulmonary disease, and more prevalent than AIDS. Chronic HBV infection can range from an asymptomatic carrier state to continuous hepatocellular necrosis and inflammation, and can lead to hepatocellular carcinoma.

[0038] The immune response to HBV is believed to play an important role in controlling hepatitis B infection. A variety of humoral and cellular responses to different regions of the HBV nucleocapsid core and surface antigens have been identified. T cell mediated immunity, particularly involving class I human leukocyte antigen-restricted cytotoxic T lymphocytes (CTL), is believed to be crucial in combating established HBV infection.

[0039] Class I human leukocyte antigen (HLA) molecules are expressed on the surface of almost all nucleated cells. CTL recognize peptide fragments, derived from intracellular processing of various antigens, in the form of a complex with class I HLA molecules. This recognition event then results in the destruction of the cell bearing the HLA-peptide complex directly or the activation of non-destructive mechanisms e.g., the production of interferon, that inhibit viral replication.

[0040] Several studies have emphasized the association between self-limiting acute hepatitis and multispecific CTL responses (Penna, A. et al., J. Exp. Med. 174:1565, 1991; Nayersina, R. et al., J. Immunol. 150:4659, 1993). Spontaneous and interferon-related clearance of chronic HBV infection is also associated with the resurgence of a vigorous CTL response (Guidotti, L. G. et al., Proc. Natl. Acad. Sci. USA 91:3764, 1994). In all such cases the CTL responses are polyclonal, and specific for multiple viral proteins including the HBV envelope, core and polymerase antigens. By contrast, in patients with chronic hepatitis, the CTL activity is usually absent or weak, and antigenically restricted.

[0041] The crucial role of CTL in resolution of HBV infection has been further underscored by studies using HBV transgenic mice. Adoptive transfer of HBV-specific CTL into mice transgenic for the HBV genome resulted in suppression of virus replication. This effect was primarily mediated by a non-lytic, lymphokine-based mechanism (Guidotti, L. G. et al., Proc. Natl. Acad. Sci. USA 91:3764, 1994; Guidotti, L. G., Guilhot, S., and Chisari, F. V. J. Virol. 68:1265, 1994; Guidotti, L. G. et al., J. Virol. 69:6158, 1995; Gilles, P. N., Fey, G., and Chisari, F. V., J. Virol. 66:3955, 1992).

[0042] As is the case for HLA class I restricted responses, HLA class II restricted T cell responses are usually detected in patients with acute hepatitis, and are absent or weak in patients with chronic infection (Chisari, F. V. and Ferrari, C., Annu. Rev. Immunol. 13:29, 1995). HLA Class II responses are tied to activation of helper T cells (HTLs) Helper T lymphocytes, which recognize Class II HLA molecules, may directly contribute to the clearance of HBV infection through the secretion of cytokines which suppress viral replication (Franco, A. et al., J. Immunol. 159:2001, 1997). However, their primary role in disease resolution is believed to be mediated by inducing activation and expansion of virus-specific CTL and B cells.

[0043] In view of the heterogeneous immune response observed with HBV infection, induction of a multi-specific cellular immune response directed simultaneously against multiple epitopes appears to be important for the development of an efficacious vaccine against HBV. There is a need to establish vaccine embodiments that elicit immune responses that correspond to responses seen in patients that clear HBV infection. Epitope-based vaccines appear useful.

[0044] Upon development of appropriate technology, the use of epitope-based vaccines has several advantages over current vaccines. The epitopes for inclusion in such a vaccine are to be selected from conserved regions of viral or tumor-associated antigens, in order to reduce the likelihood of escape mutants. The advantage of an epitope-based approach over the use of whole antigens is that there is evidence that the immune response to whole antigens is directed largely toward variable regions of the antigen, allowing for immune escape due to mutations. Furthermore, immunosuppressive epitopes that may be present in whole antigens can be avoided with the use of epitope-based vaccines.

[0045] Additionally, with an epitope-based vaccine approach, there is an ability to combine selected epitopes (CTL and HTL) and additionally to modify the composition of the epitopes, achieving, for example, enhanced immunogenicity. Accordingly, the immune response can be modulated, as appropriate, for the target disease. Similar engineering of the response is not possible with traditional approaches.

[0046] Another major benefit of epitope-based immune-stimulating vaccines is their safety. The possible pathological side effects caused by infectious agents or whole protein antigens, which might have their own intrinsic biological activity, is eliminated.

[0047] An epitope-based vaccine also provides the ability to direct and focus an immune response to multiple selected antigens from the same pathogen. Thus, patient-by-patient variability in the immune response to a particular pathogen may be alleviated by inclusion of epitopes from multiple antigens from that pathogen in a vaccine composition. A "pathogen" may be an infectious agent or a tumor associated molecule.

[0048] However, one of the most formidable obstacles to the development of broadly efficacious epitope-based immunotherapeutics has been the extreme polymorphism of HLA molecules. To date, effective non-genetically biased coverage of a population has been a task of considerable complexity; such coverage has required that epitopes be used specific for HLA molecules corresponding to each individual HLA allele, therefore, impractically large numbers of epitopes would have to be used in order to cover ethnically diverse populations. There has existed a need to develop peptide epitopes that are bound by multiple HLA antigen molecules for use in epitope-based vaccines. The greater the number of HLA antigen molecules bound, the greater the breadth of population coverage by the vaccine.

[0049] Furthermore, as described herein in greater detail, a need has existed to modulate peptide binding properties, for example so that peptides that are able to bind to multiple HLA antigens do so with an affinity that will stimulate an immune response. Identification of epitopes restricted by more than one HLA allele at an affinity that correlates with immunogenicity is important to provide thorough population coverage, and to allow the elicitation of responses of sufficient vigor whereby the natural immune responses noted in self-limiting acute hepatitis, or of spontaneous clearance of chronic HBV infection is induced in a diverse segment of the population. Such a response can also target a broad array of epitopes. The technology disclosed herein provides for such favored immune responses.

[0050] The information provided in this section is intended to disclose the presently understood state of the art as of the filing date of the present application. Information is included in this section which was generated subsequent to the priority date of this application. Accordingly, background in this section is not intended, in any way, to delineate the priority date for the invention.

II. SUMMARY OF THE INVENTION

[0051] This invention applies our knowledge of the mechanisms by which antigen is recognized by T cells, for example, to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of specific epitope pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.

[0052] An embodiment of the present invention includes a peptide composition of less than 100 amino acid residues comprising a peptide epitope useful for inducing an immune response against hepatitis B virus (HBV) said epitope (a) having an amino acid sequence of about 8 to about 13 amino acid residues that have at least 65% identity with a native amino acid sequence for HBV, and, (b) binding to at least one MEC class I HLA allele with a dissociation constant of less than about 500 nM. Further, the peptide composition may comprise an amino acid sequence of at least 77% identity, or at least 100% identity with a native HBV amino acid sequence. In a preferred embodiment, the peptide is one of the peptides designated as being from the envelope, polymerase, protein X, or nucleocapsid core regions of HBV. Preferred peptides are described in Tables VI through XVII or XXI.

[0053] An additional embodiment of the present invention comprises a composition of less than 100 amino acid residues comprising a peptide epitope useful for inducing an immune response against hepatitis B virus (HBV) said peptide (a) having an amino acid sequence of about 8 to about 13 amino acid residues and (b) bearing one of the HLA supermotifs or motifs set out in Tables I and II. Furthermore, the composition may comprise a peptide wherein the peptide is one of those described in Tables VI through XVII or Table XXI which bear an HLA A1, A2, A3, A24, B7, B27, B44, B58, or B62 supermotif; or an HLA A1, A3, A11, A24, or A2.1 motif or an HLA A*3301, A*3101, A*6801, B*0702, B*3501, B51, B*5301, B*5401 motif.

[0054] In one embodiment of a peptide comprising an HLA A2.1 motif, the peptide does not bear an L or M at position 2 and V at the C-terminal position 9 of a 9 amino acid peptide.

[0055] An alternative embodiment of the invention comprises an analog of an HBV peptide of less than 100 amino acid residues in length that bears an HLA binding motif, the analog bearing the same HLA binding motif as the peptide but comprising at least one anchor residue that is different from that of the peptide. In a preferred embodiment, said peptide is an analog of a peptide described in Table VI through Table XVII bearing an HLA A1, A2, A3, A24, B7, B27, B44, B58, or B62 supermotif; or an HLA A1, A3, A11, A24, or A2.1 motif or A3301, A3101, A6801, B0702, B3501, B51, B5301, B5401 motif.

[0056] Embodiments of the invention further include a composition of less than 100 amino acid residues comprising a peptide epitope useful for inducing an immune response against hepatitis B virus (HBV) said peptide (a) having an amino acid sequence of about 9 to about 25 amino acid residues that have at least 65% identity with a native amino acid sequence for HBV and (b) binding to at least one MHC class II HLA allele with a dissociation constant of less than about 1000 nM. In a preferred embodiment, the composition comprises a peptide that has at least 77%, or, 100% identity with a native HBV amino acid sequence. Further, the composition may comprise a peptide wherein said peptide is one of those peptides described in Table XVIII or Table XIX.

[0057] The invention also includes a peptide composition of less than 100 amino acid residues, said composition comprising an epitope useful for inducing an immune response against hepatitis B virus (HBV) said epitope (a) having an amino acid sequence of about 10 to about 20 amino acid residues and (b) bearing one of the class II HLA motifs set out in Table III. In a preferred embodiment, said peptide is one of those peptides described in Table XVIII or XIX.

[0058] Additional embodiments of the invention include a composition that comprises an isolated nucleic acid sequence that encodes one of the peptides set out in Tables VI through XIX or XXI or XXIII.

[0059] Alternatively, an embodiment of the invention comprises a composition that comprises at least two peptides, at least one of said at least two peptides selected from Tables VI-XIX or XXI or XXIII. In a preferred embodiment, two or more of the at least two peptides are depicted in Tables VI-XIX or XXI or XXIII. The composition may further comprise at least one nucleic acid sequence. In a preferred embodiment each of said at least two peptides are encoded by a nucleic acid sequence, wherein each of the nucleic acid sequences are located on a single vector.

[0060] Embodiments of the invention additionally include a peptide composition of less than 100 amino acid residues, said composition comprising an epitope useful for inducing an immune response against HBV, said epitope having at least one of the amino acid sequences set out in Table XXIII.

[0061] An alternative modality for defining the peptides in accordance with the invention is to recite the physical properties, such as length; primary, secondary and/or tertiary structure; or charge, which are correlated with binding to a particular allele-specific HLA molecule or group of allele-specific HLA molecules. A further modality for defining peptides is to recite the physical properties of an HLA binding pocket, or properties shared by several allele-specific HLA binding pockets (e.g. pocket configuration and charge distribution) and reciting that the peptide fits and binds to said pocket or pockets.

[0062] An additional embodiment of the invention comprises a method for inducing a cytotoxic T cell response to HBV in a mammal comprising administering to said mammal at least one peptide from Tables VI to XIX or Table XXI.

[0063] Further embodiments of the invention include a vaccine for treating HBV infection that induces a protective immune response, wherein said vaccine comprises at least one peptide selected from Tables VI to Table XIX or Table XXI in a pharmaceutically acceptable carrier.

[0064] Also included as an embodiment of the invention is a vaccine for preventing HBV infection that induces a protective immune response, wherein said vaccine comprises at least one peptide selected from Tables VI to XIX or Table XXI in a pharmaceutically acceptable carrier.

[0065] The invention further includes an embodiment comprising a method for inducing a cytotoxic T cell response to HBV in a mammal, comprising administering to said mammal a nucleic acid sequence encoding a peptide selected from Tables VI to XIX or Table XXI.

[0066] A further embodiment of the invention comprises a kit for a vaccine for treating or preventing HBV infection, wherein the vaccine induces a protective immune response, said vaccine comprising at least one peptide selected from Tables VI to XIX or Table XXI in a pharmaceutically acceptable carrier and instructions for administration to a patient.

[0067] Lastly, the invention includes an embodiment comprising a method for monitoring immunogenic activity of a vaccine for HBV in a patient having a known HLA-type, the method comprising incubating a T lymphocyte sample from the patient with a peptide selected from Tables VI to XIX or Table XXI which binds the product of at least one HLA allele present in said patient, and detecting for the presence of a T lymphocyte that binds to the peptide. In a preferred embodiment, the peptide comprises a tetrameric complex.

[0068] As will be apparent from the discussion below, other methods and embodiments are also contemplated. Further, novel synthetic peptides produced by any of the methods described herein are also part of the invention.

III. BRIEF DESCRIPTION OF THE FIGURES

[0069] FIG. 1: FIG. 1 Illustrates the Position of Peptide Epitopes in Experimental Model Minigene Constructs

IV. DETAILED DESCRIPTION OF THE INVENTION

[0070] The peptides and corresponding nucleic acid compositions of the present invention are useful for stimulating an immune response to HBV either by stimulating the production of CTL or HTL responses. The peptides, which are derived directly or indirectly from native HBV amino acid sequences, are able to bind to HLA molecules and stimulate an immune response to HBV. The complete polyprotein sequence from HBV and its variants can be obtained from Genbank. Peptides can also be readily determined from sequence information that may subsequently be discovered for heretofore unknown variants of HBV as will be clear from the disclosure provided below.

[0071] The peptides of the invention have been identified in a number of ways, as will be discussed below. Further, analog peptides have been derived and the binding activity for HLA molecules modulated by modifying specific amino acid residues to create peptide analogs exhibiting altered immunogenicity. Further, the present invention provides compositions and combinations of compositions that enable epitope-based vaccines that are capable of interacting with multiple HLA antigens to provide broader population coverage than prior vaccines.

[0072] The invention can be better understood with reference to the following definitions:

IV.A. DEFINITIONS

[0073] "Cross-reactive binding" indicates that a peptide is bound by more than one HLA molecule; a synonym is degenerate binding.

[0074] A "cryptic epitope" elicits a response by immunization with an isolated peptide, but the response is not cross-reactive in vitro when intact whole protein which comprises the epitope is used as an antigen.

[0075] A "dominant epitope" is an epitope that induces an immune response upon immunization with a whole native antigen. (See, e.g., Sercarz, et al., Annu. Rev. Immunol. 11:729766 (1993)) Such a response is cross-reactive in vitro with an isolated peptide epitope.

[0076] With regard to a particular amino acid sequence, an "epitope" is a set of amino acid residues which is involved in recognition by a particular immunoglobulin, or in the context of T cells, those residues necessary for recognition by T cell receptor proteins and/or Major Histocompatibility Complex (MHC) receptors. In an immune system setting, in vivo or in vitro, an epitope is the collective features of a molecule, such as primary, secondary and tertiary peptide structure, and charge, that together form a site recognized by an immunoglobulin, T cell receptor or HLA molecule.

[0077] As used herein, "high affinity" with respect to HLA class I molecules is defined as binding with an IC.sub.50 (or K.sub.D) of less than 50 nM. "Intermediate affinity" is binding with an IC.sub.50 (or K.sub.D) of between about 50 and about 500 nM. "High affinity" with respect to binding to HLA class II molecules is defined as binding with an K.sub.D of less than 100 nM. "Intermediate affinity" is binding with a K.sub.D of between about 100 and about 1000 nM. Assays for determining binding are described in detail in PCT publications WO 94/20127 and WO 94/03205. Alternatively, binding is expressed relative to a reference peptide. As a particular assay becomes more, or less, sensitive, the IC.sub.50's of the peptides tested may change somewhat. However, the binding relative to the reference peptide will not significantly change. For example, in an assay run under conditions such that the IC.sub.50 of the reference peptide increases 10-fold, the IC.sub.50 values of the test peptides will also shift approximately 10-fold. Therefore, to avoid ambiguities, the assessment of whether a peptide is a good, intermediate, weak, or negative binder is generally based on its IC.sub.50, relative to the IC.sub.50 of a standard peptide.

[0078] "Human Leukocyte Antigen" or "HLA" is a human class I or class II Major Histocompatibility Complex (MEC) protein (see, Stites, et al., IMMUNOLOGY, 8.sup.TH ED., Lange Publishing, Los Altos, Calif. (1994).

[0079] An "HLA supertype or family", as used herein, describes sets of HLA molecules grouped on the basis of shared peptide-binding specificities. HLA class I molecules that share somewhat similar binding affinity for peptides bearing certain amino acid motifs are grouped into HLA supertypes. The terms HLA superfamily, HLA supertype family, and HLA xx-like supertype molecules (where xx denotes a particular HLA type) are synonyms.

[0080] Throughout this disclosure, results are expressed in terms of "IC.sub.50's." IC.sub.50 is the concentration of peptide in a binding assay at which 50% inhibition of binding of a reference peptide is observed. Given the conditions in which the assays are run (i.e., limiting HLA proteins and labeled peptide concentrations), these values approximate K.sub.D values. It should be noted that IC.sub.50 values can change, often dramatically, if the assay conditions are varied, and depending on the particular reagents used (e.g., HLA preparation, etc.). For example, excessive concentrations of HLA molecules will increase the apparent measured IC.sub.50 of a given ligand.

[0081] The terms "identical" or percent "identity," in the context of two or more peptide sequences, refer to two or more sequences or subsequences that are the same or have a specified percentage of amino acid residues that are the same, when compared and aligned for maximum correspondence over a comparison window, as measured using a sequence comparison algorithms or by manual alignment and visual inspection.

[0082] An "immunogenic peptide" or "peptide epitope" is a peptide which comprises an allele-specific motif or supermotif such that the peptide will bind an HLA molecule and induce a CTL and/or HTL response. Thus, immunogenic peptides of the invention are capable of binding to an appropriate HLA molecule and thereafter inducing a cytotoxic T cell response, or a helper T cell response, to the antigen from which the immunogenic peptide is derived.

[0083] The phrases "isolated" or "biologically pure" refer to material which is substantially or essentially free from components which normally accompany the material as it is found in its native state. Thus, isolated peptides in accordance with the invention preferably do not contain materials normally associated with the peptides in their in situ environment.

[0084] "Major Histocompatibility Complex" or "MHC" is a cluster of genes that plays a role in control of the cellular interactions responsible for physiologic immune responses. In humans, the MHC complex is also known as the HLA complex. For a detailed description of the MHC and HLA complexes, see, Paul, FUNDAMENTAL IMMUNOLOGY, 3.sup.RD ED., Raven Press, New York, 1993.

[0085] The term "motif" refers to the pattern of residues in a peptide of defined length, usually a peptide of from about 8 to about 13 amino acids for a class I HLA motif and from about 6 to about 25 amino acids for a class II HLA motif, which is recognized by a particular HLA molecule. Peptide motifs are typically different for each protein encoded by each human HLA allele and differ in the pattern of the primary and secondary anchor residues.

[0086] A "negative binding residue" is an amino acid which if present at certain positions (typically not primary anchor positions) of peptide epitope results in decreased binding affinity of the peptide for the peptide's corresponding HLA molecule.

[0087] The term "peptide" is used interchangeably with "oligopeptide" in the present specification to designate a series of residues, typically L-amino acids, connected one to the other, typically by peptide bonds between the amino and carboxyl groups of adjacent amino acids. The preferred CTL-inducing oligopeptides of the invention are fewer than 25 residues in length, or less than 15 residues in length or 13 residues or less in length and usually consist of between about 8 and about 11 residues, preferably 9 or 10 residues. The preferred HTL-inducing oligopeptides are less than about 50 residues in length and usually consist of between about 6 and about 30 residues, more usually between about 12 and 25, and often between about 15 and 20 residues.

[0088] "Pharmaceutically acceptable" refers to a non-toxic, inert, and physiologically compatible composition.

[0089] A "primary anchor residue" is an amino acid at a specific position along a peptide sequence which is understood to provide a contact point between the immunogenic peptide and the HLA molecule. One to three, usually two, primary anchor residues within a peptide of defined length generally defines a "motif" for an immunogenic peptide. These residues are understood to fit in close contact with peptide binding grooves of an HLA molecule, with their side chains buried in specific pockets of the binding grooves themselves. In one embodiment, the primary anchor residues are located at position 2 (from the amino terminal position) and at the carboxyl terminal position of a 9 residue peptide in accordance with the invention. The primary anchor positions for each motif and supermotif are set forth in Table I. For example, analog peptides can be created by altering the presence or absence of particular residues in these primary anchor positions. Such analogs are used to finely modulate the binding affinity of a peptide comprising a particular motif or supermotif.

[0090] "Promiscuous binding" is where a distinct peptide is recognized by the same T cell clone in the context of various HLA molecules.

[0091] A "protective immune response" refers to a CTL and/or an HTL response to an antigen from an infectious agent or a tumor antigen from which an immunogenic peptide is derived, and thereby preventing or at least partially arresting disease symptoms or progression. The immune response may also include an antibody response which has been facilitated by the stimulation of helper T cells.

[0092] The term "residue" refers to an amino acid or amino acid mimetic incorporated into an oligopeptide by an amide bond or amide bond mimetic.

[0093] A "secondary anchor residue" is an amino acid at a position other than a primary anchor position in a peptide which may influence peptide binding. A secondary anchor residue occurs at a significantly higher frequency amongst bound peptides than would be expected by random distribution of amino acids at one position. The secondary anchor residues are said to occur at "secondary anchor positions." A secondary anchor residue can be identified as a residue which is present at a higher frequency among high affinity binding peptides, or a residue otherwise associated with high affinity binding. For example, analog peptides can be created by altering the presence or absence of particular residues in these secondary anchor positions. Such analogs are used to finely modulate the binding affinity of a peptide comprising a particular motif or supermotif.

[0094] A "subdominant epitope" is an epitope which evokes little or no response upon immunization with whole antigens which comprise the epitope, but for which a response can be obtained by immunization with an isolated peptide, and this response (unlike the case of cryptic epitopes) is detected when whole protein is used to recall the response in vitro or in vivo.

[0095] A "supermotif" is a peptide binding specificity shared by HLA molecules encoded by two or more HLA alleles. Thus, a preferably is recognized with high or intermediate affinity (as defined herein) by two or more HLA antigens.

[0096] "Synthetic peptide" refers to a peptide that is not naturally occurring, but is man-made using such methods as chemical synthesis or recombinant DNA technology.

[0097] The nomenclature used to describe peptide compounds follows the conventional practice wherein the amino group is presented to the left (the N-terminus) and the carboxyl group to the right (the C-terminus) of each amino acid residue. When amino acid residue positions are referred to in a peptide epitope they are numbered in an amino to carboxyl direction with position one being the position closest to the amino terminal. In the formulae representing selected specific embodiments of the present invention, the amino- and carboxyl-terminal groups, although not specifically shown, are in the form they would assume at physiologic pH values, unless otherwise specified. In the amino acid structure formulae, each residue is generally represented by standard three letter or single letter designations. The L-form of an amino acid residue is represented by a capital single letter or a capital first letter of a three-letter symbol, and the D-form for those amino acids having D-forms is represented by a lower case single letter or a lower case three letter symbol. Glycine has no asymmetric carbon atom and is simply referred to as "Gly" or G. Symbols for the amino acids are shown below.

TABLE-US-00001 Single Three Letter Symbol Letter Symbol Amino Acids A Ala Alanine C Cys Cysteine D Asp Aspartic Acid E Glu Glutamic Acid F Phe Phenylalanine G Gly Glycine H His Histidine I Ile Isoleucine K Lys Lysine L Leu Leucine M Met Methionine N Asn Asparagine P Pro Proline Q Gln Glutamine R Arg Arginine S Ser Serine T Thr Threonine V Val Valine W Trp Tryptophan Y Tyr Tyrosine

IV.B. STIMULATION OF CTL AND HTL RESPONSES AGAINST HBV

[0098] The mechanism by which T cells recognize antigens has been delineated during the past ten years. Based on our new understanding of the immune system we have generated efficacious peptide epitope vaccine compositions that can induce a therapeutic or prophylactic immune response to HBV infection in a broad population. For an understanding of the value and efficacy of the claimed compositions, a brief review of the technology is provided.

[0099] A complex of an HLA molecule and a peptidic antigen acts as the ligand recognized by HLA-restricted T cells (Buus, S. et al., Cell 47:1071, 1986; Babbitt, B. P. et al., Nature 317:359, 1985; Townsend, A., and Bodmer, H., Annu. Rev. Immunol. 7:601, 1989; Germain, R. N., Annu. Rev. Immunol. 11:403, 1993). Through the study of single amino acid substituted antigen analogs and the sequencing of endogenously bound, naturally processed peptides, critical residues that correspond to motifs required for specific binding to HLA antigen molecules have been identified and are described here and set forth in Tables I, II, and III (see also, e.g., Sette, A. and Grey, H. M., Curr. Opin. Immunol. 4:79, 1992; Sinigaglia, F. and Hammer, J., Curr. Biol. 6:52, 1994; Engelhard, V. H., Curr. Opin. Immunol. 6:13, 1994). Furthermore, x-ray crystallographic analysis of HLA-peptide complexes has revealed pockets within the peptide binding cleft of HLA molecules which accommodate allele-specific residues borne by peptide ligands; these residues in turn determine the HLA binding capacity of the peptides in which they are present (Brown, J. H. et al., Nature 364:33, 1993; Guo, H. C. et al., Proc. Natl. Acad. Sci. USA 90:8053, 1993; Guo, H. C. et al., Nature 360:364, 1992; Silver, M. L. et al., Nature 360:367, 1992; Matsumura, M. et al., Science 257:927, 1992; Madden et al., Cell 70:1035, 1992; Fremont, D. H. et al., Science 257:919, 1992; Saper, M. A., Bjorkman, P. J. and Wiley, D.C., J. Mol. Biol. 219:277, 1991).

[0100] Accordingly, the definition of class I and class II allele-specific HLA binding motifs or class I supermotifs allows identification of regions within a protein that have the potential of binding particular HLA antigens (see also e.g., Sette, A. and Grey, H. M., Curr. Opin. Immunol. 4:79, 1992; Sinigaglia, F. and Hammer, J., Curr. Biol. 6:52, 1994; Engelhard, V. H., Curr. Opin. Immunol. 6:13, 1994 Kast, W. M. et al., J. Immunol., 152:3904, 1994).

[0101] Furthermore, a variety of assays to detect and quantify the affinity of interaction between peptide and HLA have also been established (Sette, A. and Grey, H. M., Curr. Opin. Immunol. 4:79, 1992; Sinigaglia, F. and Hammer, J., Curr. Biol. 6:52, 1994; Engelhard, V. H., Curr. Opin. Immunol. 6:13, 1994).

[0102] We have found that the correlation of binding affinity with immunogenicity is an important factor to be considered when evaluating candidate peptides. Thus, by a combination of motif searches and HLA-peptide binding assays, candidates for epitope-based vaccines have been identified. After determining their binding affinity, additional confirmatory work can be performed to select, amongst these vaccine candidates, epitopes with desired characteristics in terms of antigenicity and immunogenicity. Various strategies can be utilized to evaluate immunogenicity, including:

[0103] 1) Primary T cell cultures from normal individuals (Wentworth, P. A. et al., Mol. Immunol. 32:603, 1995; Celis, E. et al., Proc. Natl. Acad. Sci. USA 91:2105, 1994; Tsai, V. et al., J. Immunol. 158:1796, 1997; Kawashima, I. et al., Human Immunol. 59:1, 1998); This procedure involves the stimulation of PBL from normal subjects with a test peptide in the presence of antigen presenting cells in vitro over a period of several weeks. T cells specific for the peptide become activated during this time and are detected using a .sup.51 Cr-release assay involving peptide sensitized target cells.

[0104] 2) Immunization of HLA transgenic mice (Wentworth, P. A. et al., J. Immunol. 26:97, 1996; Wentworth, P. A. et al., Int. Immunol. 8:651, 1996; Alexander, J. et al., J. Immunol. 159:4753, 1997); In this method, peptides in incomplete Freund's adjuvant are administered subcutaneously to HLA transgenic mice. Several weeks following immunization, splenocytes are removed and cultured in vitro in the presence of test peptide for approximately one week. Peptide-specific T cells are detected using a .sup.51Cr-release assay involving peptide sensitized target cells and target cells expressing endogenously generated antigen.

[0105] 3) Demonstration of recall T cell responses from immune individuals who have recovered from infection, and/or from chronically infected patients (Rehermann, B. et al., J. Exp. Med. 181:1047, 1995; Doolan, D. L. et al., Immunity 7:97, 1997; Bertoni, R. et al., J. Clin. Invest. 100:503, 1997; Threlkeld, S. C. et al., J. Immunol. 159:1648, 1997; Diepolder, H. M. et al., J. Virol. 71:6011, 1997). In applying this strategy, recall responses were detected by culturing PBL from subjects that had been naturally exposed to the antigen, for instance through infection, and thus had generated an immune response "naturally". PBL from subjects were cultured in vitro for 1-2 weeks in the presence of test peptide plus antigen presenting cells (APC) to allow activation of "memory" T cells, as compared to "naive" T-cells. At the end of the culture period, T cell activity is detected using assays for T cell activity including .sup.51Cr release involving peptide-sensitized targets, T cell proliferation or lymphokine release.

[0106] The following describes the peptide epitopes and corresponding nucleic acids of the invention.

IV.C. IMMUNE RESPONSE STIMULATING PEPTIDES

[0107] As indicated herein, the large degree of HLA polymorphism is an important factor to be taken into account with the epitope-based approach to vaccine development. To address this factor, epitope selection encompassing identification of peptides capable of binding at high or intermediate affinity to multiple HLA molecules is preferably utilized, most preferably these epitopes bind at high or intermediate affinity to two or more allele specific HLA molecules.

IV.C.1. Binding Affinity of the Peptides for HLA Molecules

[0108] CTL-inducing peptides of interest for vaccine compositions preferably include those that have a binding affinity for class I HLA molecules of less than 500 nM. HTL-inducing peptides preferably include those that have a binding affinity for class II HLA molecules of less than 1000 nM. For example, peptide binding is assessed by testing the capacity of a candidate peptide to bind to a purified HLA molecule in vitro. Peptides exhibiting high or intermediate affinity are then considered for further analysis. Selected peptides are tested on other members of the supertype family. In preferred embodiments, peptides that exhibit cross-reactive binding preferably are then used in cellular screening analyses. A peptide is considered to be an epitope if it possesses the molecular features that form the binding site for a particular immunoglobulin or T cell receptor protein.

[0109] As disclosed herein, high HLA binding affinity is correlated with greater immunogenicity. Greater immunogenicity can be manifested in several different ways. Immunogenicity corresponds to whether an immune response is elicited at all, and to the vigor of any particular response. For example, a peptide might elicit an immune response in a diverse array of the population, yet in no instance produce a vigorous response. In accordance with these principles, close to 90% of high binding peptides have been found to be immunogenic, as contrasted with about 50% of the peptides which bind with intermediate affinity. Moreover, higher binding affinity peptides leads to more vigorous immunogenic responses. As a result, less peptide is required to elicit a similar biological effect if a high affinity binding peptide is used. Thus, in preferred embodiments of the invention, high binding epitopes are particularly desired.

[0110] The relationship between binding affinity for HLA class I molecules and immunogenicity of discrete peptide epitopes on bound antigens has been determined for the first time in the art by the present inventors. The correlation between binding affinity and immunogenicity was analyzed in two different experimental approaches (Sette, et al., J. Immunol. 153:5586-5592, 1994). In the first approach, the immunogenicity of potential epitopes ranging in HLA binding affinity over a 10,000-fold range was analyzed in HLA-A*0201 transgenic mice. In the second approach, the antigenicity of approximately 100 different hepatitis B virus (HBV)-derived potential epitopes, all carrying A*0201 binding motifs, was assessed by using PBL (peripheral blood lymphocytes) of acute hepatitis patients. Pursuant to these approaches, it was determined that an affinity threshold of approximately 500 nM (preferably 500 nM or less) determines the capacity of a peptide epitope to elicit a CTL response. These data are true for class I binding affinity measurements for naturally processed peptides and for synthesized T cell epitopes. These data also indicate the important role of determinant selection in the shaping of T cell responses.

[0111] An affinity threshold associated with immunogenicity in the context of HLA class II DR molecules has also been delineated (Southwood et al. J. Immunology 160:3363-3373, 1998, and U.S. Ser. No. 60/087,192 filed May 29, 1998). In order to define a biologically significant threshold of DR binding affinity, a database of the binding affinities of 32 DR-restricted epitopes for their restricting element was compiled. In approximately half of the cases (15 of 32 epitopes), DR restriction was associated with high binding affinities, i.e. binding affinities of less than 100 nM. In the other half of the cases (16 of 32), DR restriction was associated with intermediate affinity (binding affinities in the 100-1000 nM range). In only one of 32 cases was DR restriction associated with an IC.sub.50 of 1000 nM or greater. Thus, 1000 nM can be defined as an affinity threshold associated with immunogenicity in the context of DR molecules.

[0112] The binding affinity of peptides for HLA molecules can be determined as described in Example 1, below.

IV.C.2. Peptide Binding Motifs and Supermotifs

[0113] In the past few years evidence has accumulated to demonstrate that a large fraction of HLA class I, and possibly class II molecules can be classified into a relatively few supertypes characterized by largely overlapping peptide binding repertoires, and consensus structures of the main peptide binding pockets. Through the study of single amino acid substituted antigen analogs and the sequencing of endogenously bound, naturally processed peptides, critical residues required for allele-specific binding to HLA molecules have been identified. These motifs are relevant since they indicate peptides that have binding affinity for HLA molecules.

[0114] For HLA molecule pocket analyses, the residues comprising the B and F pockets of HLA class I molecules as described in crystallographic studies (Guo, H. C. et al., Nature 360:364, 1992; Saper, M. A., Bjorkman, P. J. and Wiley, D.C., J. Mol. Biol. 219:277, 1991; Madden, D. R., Garboczi, D. N. and Wiley, D.C., Cell 75:693, 1993), have been compiled from the database of Parham, et al. (Parham, P., Adams, E. J., and Arnett, K. L., Immunol. Rev. 143:141, 1995). In these analyses, residues 9, 45, 63, 66, 67, 70, and 99 were considered to make up the B pocket, and to determine the specificity for the residue in the second position of peptide ligands. Similarly, residues 77, 80, 81, and 116 were considered to determine the specificity of the F pocket, and to determine the specificity for the C-terminal residue of a peptide ligand bound by the HLA molecule.

[0115] Peptides of the present invention may also include epitopes that bind to MHC class II DR molecules. A significant difference between class I and class II HLA molecules is that, although a stringent size restriction exists for peptide binding to class I molecules, a greater degree of heterogeneity in both sizes and binding frame positions of the motif, relative to the N and C termini of the peptide, can be demonstrated for class II peptide ligands. This increased heterogeneity is due to the structure of the class II-binding groove which, unlike its class I counterpart, is open at both ends. Crystallographic analysis of DRB*0101-peptide complexes (see, e.g., Madden, D. R. Ann. Rev. Immunol. 13:587 (1995)) showed that the residues occupying position 1 and position 6 of peptides complexed with DRB*0101 engage two complementary pockets on the DRBa*0101 molecules, with the P1 position corresponding to the most crucial anchor residue and the deepest hydrophobic pocket. Other studies have also pointed to the P6 position as a crucial anchor residue for binding to various other DR molecules.

[0116] Thus, peptides of the present invention are identified by any one of several HLA-specific amino acid motifs. If the presence of the motif corresponds to the ability to bind several allele-specific HLA antigens it is referred to as a supermotif. The allele-specific HLA molecules that bind to peptides that possess a particular amino acid supermotif are collectively referred to as an HLA "supertype."

[0117] The peptide motifs and supermotifs described below provide guidance for the identification and use of peptides in accordance with the invention. Examples of peptide epitopes bearing the respective supermotif or motif are included in Tables as designated in the description of each motif or supermotif. The Tables include a binding affinity ratio listing for some of the peptide epitopes. The ratio may be converted to IC.sub.50 by using the following formula: IC.sub.50 of the standard peptide/ratio=IC.sub.50 of the test peptide (i.e. the peptide epitope). The IC.sub.50 values of standard peptides used to determine binding affinities for Class I peptides are shown in Table IV. The IC.sub.50 values of standard peptides used to determine binding affinities for Class II peptides are shown in Table V. The peptides used as standards for the binding assay are examples of standards; alternative standard peptides can also be used when performing such an analysis.

[0118] To obtain the peptide epitope sequences listed in each Table, protein sequence data from twenty HBV strains (HPBADR, HPBADR1CG, HPBADRA, HPBADRC, HPBADRCG, HPBCGADR, HPBVADRM, HPBADW, HPBADW1, HPBADW2, HPBADW3, HPBADWZ, HPBHEPB, HPBVADW2, HPBADR, HPBV, HPBVAYWC, HPBVAYWCI, NAD HPBVAYWE) were evaluated for the presence of the designated supermotif or motif. Peptide epitopes were also selected on the basis of their conservancy. A criterion for conservancy requires that the entire sequence of a peptide be totally conserved in 75% of the sequences available for a specific protein. The percent conservancy of the selected peptide epitopes is indicated on the Tables. The frequency, i.e. the number of strains of the 20 strains in which the peptide sequence was identified, is also shown. The "1.sup.st position" column in the Tables designates the amino acid position of the HBV polyprotein that corresponds to the first amino acid residue of the epitope. Preferred peptides are designated by an asterisk.

HLA Class I Motifs Indicative of CTL Inducing Peptide Epitopes:

IV.C.2.a) HLA-A1 Supermotif

[0119] The HLA-A1 supermotif is characterized by peptides having a general motif of small (T or S) and hydrophobic (L, I, V, M, or F) primary anchor residues in position 2, and aromatic (Y, F, or W) primary anchor residues at the C-terminal position The corresponding family of HLA molecules that bind to the A1 supermotif (the HLA-A1 supertype) includes A*0101, A*2601, A*2602, A*2501, and A*3201. (DiBrino, M. et al., J. Immunol. 151:5930, 1993; DiBrino, M. et al., J. Immunol. 152:620, 1994; Kondo, A. et al., Immunogenetics 45:249, 1997; Dumrese et al., submitted). Peptides binding to each of the individual HLA proteins can be modulated by substitutions at primary anchor positions.

[0120] Representative peptide epitopes that contain the A1 supermotif are set forth on the attached Table VI.

IV.C.2.b) HLA-A2 Supermotif

[0121] The HLA-A2 supermotif is characterized by the presence in peptide ligands of small or aliphatic amino acids (L, I, V, M, A, T, or Q) at position 2 and L, I, V, M, A, or T at the C-terminal position. These positions are referred to as primary anchors. The corresponding family of HLA molecules (the HLA-A2 supertype that binds these peptides) is comprised of at least nine HLA-A proteins: A*0201, A*0202, A*0203, A*0204, A*0205, A*0206, A*0207, A*6802, and A*6901. As explained in detail below, binding to each of the individual allele-specific HLA molecules can be modulated by substitutions at the primary anchor and/or secondary anchor positions.

[0122] Representative peptide epitopes that contain the A2 supermotif are set forth on the attached Table VII.

IV.C.2.c) HLA-A3 Supermotif

[0123] The HLA-A3 supermotif is characterized by peptide ligands having primary anchor residues: A, L, I, V, M, S, or, T at position 2, and positively charged residues, such as R or K at the C-terminal position (in position 9 of 9-mers). Exemplary members of the corresponding HLA family of HLA molecules (the HLA-A3 superfamily) that bind the A3 supermotif include: A3 (A*0301), A11 (A*1101), A31 (A*3101), A*3301, and A*6801. Other allele-encoded HLA molecules predicted to be members of the A3 superfamily include A34, A66, and A*7401. As explained in detail below, peptide binding to each of the individual allele-specific HLA proteins can be modulated by substitutions of amino acids at the primary and/or secondary anchor positions of the peptide.

[0124] Representative peptide epitopes that contain the A3 supermotif are set forth on the attached Table VIII.

IV.C.2.d) HLA-A24 Supermotif

[0125] The HLA-A24 supermotif is characterized by the presence in peptide ligands of an aromatic (F, W, or Y) residue as a primary anchor in position 2 and a hydrophobic (Y, F, L, I, V, or M) residue as primary anchor at the C-terminal position. The corresponding family of HLA molecules that bind to the A24 supermotif (the A24 supertype) includes A*2402, A*3001, and A*2301. Peptide binding to each of the allele-specific HLA molecules can be modulated by substitutions at primary anchor positions.

[0126] Representative peptide epitopes that contain the A24 supermotif are set forth on the attached Table IX.

IV.C.2.e) HLA-B7 Supermotif

[0127] The HLA-B7 supermotif is characterized by peptides bearing proline in position 2 as a primary anchor and hydrophobic or aliphatic amino acids (L, I, V, M, A, F, W, or Y) as the primary anchor at the C-terminal position. The corresponding family of HLA molecules that bind the B7 supermotif (the HLA-B7 supertype) is comprised of at least a dozen HLA-B proteins including B7, B*3501-1, B*3502-2, B*3501-3, B51, B*5301, B*5401, B*5501, B*5401, B*5501, B*5502, B*5601, B*6701, and B*7801 (See, e.g., Sidney, et al., J. Immunol. 154:247 (1995); Barber, et al., Curr. Biol. 5:179 (1995); Hill, et al., Nature 360:434 (1992); Rammensee, et al., Immunogenetics 41:178 (1995)). As explained in detail below, peptide binding to each of the individual allele-specific HLA proteins can be modulated by substitutions at the primary and/or secondary anchor positions of the peptide.

[0128] Representative peptide epitopes that contain the B7 supermotif are set forth on the attached Table X.

IV.C.2.f) HLA-B27 Supermotif

[0129] The HLA-B27 supermotif is characterized by the presence in peptide ligands of positively charged (R, H, or K) residues as primary anchors at position 2 and hydrophobic (A, L, I, V, M, Y, F, or W) residues as primary anchors at the C-terminal. Exemplary members of the corresponding HLA molecules that bind to the B27 supermotif (the B27 supertype) include B*14, B*1509, B*38, B*3901, B*3902, B*73, and various B27 subtypes. Peptide binding to each of the allele-specific HLA molecules can be modulated by substitutions at primary anchor positions.

[0130] Representative peptide epitopes that contain the B27 supermotif are set forth on the attached Table XI.

IV.C.2.g) HLA-B44 Supermotif

[0131] The HLA-B44 supermotif is characterized by the presence in peptide ligands of negatively charged (D or E) residues as a primary anchor in position 2, and hydrophobic residues (F, W, Y, L, I, M V, or A) as a primary anchor at the C-terminal. Exemplary members of the corresponding family of HLA molecules that bind to the B44 supermotif (the B44 supertype) include B*3701, B*4402, B*4403, B60, and B61. Peptide binding to each of the allele-specific HLA molecules can be modulated by substitutions at primary anchor positions.

[0132] Representative peptide epitopes that contain the B44 supermotif are set forth on the attached Table XII.

IV.C.2.h) HLA-B58 Supermotif

[0133] The HLA-B58 supermotif is characterized by the presence in peptide ligands of small aliphatic residues (A, S, or T) as primary anchor residues at position 2 and aromatic or hydrophobic residues (F, W, Y, L, I, or V) as primary anchor residues at the C-terminal. Exemplary members of the corresponding HLA molecules that bind to the B58 supermotif (the B58 supertype) include B*1516, B*1517, B*5701, B*5702, and B*58. Peptide binding to each of the allele-specific HLA molecules can be modulated by substitutions at primary anchor positions.

[0134] Representative peptide epitopes that contain the B58 supermotif are set forth on the attached Table XIII.

IV.C.2.i) HLA-B62 Supermotif

[0135] The HLA-B62 supermotif is characterized by the presence in peptide ligands of the polar aliphatic residue Q or the hydrophobic aliphatic residues (L, V, M, or I) as a primary anchor in position 2 and hydrophobic residues (F, W, Y, M, I, or V) as a primary anchor at the C-terminal position. Exemplary members of the corresponding HLA molecules that a bind to the B62 supermotif (the B62 supertype) include B46, B52, B62, B75, and B77. Peptide binding to each of the allele-specific HLA molecules can be modulated by substitutions at primary anchor positions.

[0136] Representative peptide epitopes that contain the B62 supermotif are set forth on the attached Table XIV.

IV.C.2.j) HLA-A1 Motif

[0137] The allele-specific HLA-A1 motif is characterized by the presence in peptide ligands of T, S, or M as a primary anchor residue at position 2 and the presence of Y as a primary anchor residue at the C-terminal position. Alternatively, a primary anchor residue may be present at position 3 rather than position 2. This motif is characterized by the presence of D, E, A, or S as a primary anchor residue in position 3 and a Y as a primary anchor residue at the C-terminus. Peptide binding to HLA A1 can be modulated by substitutions at primary and/or secondary anchor positions.

[0138] Representative peptide epitopes that contain the A1 motif are set forth on the attached Table XV.

IV.C.2.k) HLA-A3 Motif

[0139] The allele-specific HLA-A3 motif is characterized by the presence in peptide ligands of L, M, V, I, S, A, T, F, C, G, or D as a primary anchor residue at position 2 and the presence of K, Y, R, H, F, or A as the primary anchor residue at the C-terminal position. Peptide binding to HLA-A3 can be modulated by substitutions at primary and/or secondary anchor positions.

[0140] Representative peptide epitopes that contain the A3 motif are set forth on the attached Table XVI.

IV.C.2.l) HLA-A11 Motif

[0141] The allele-specific HLA-A11 motif is characterized by the presence in peptide ligands of V, T, M, L, I, S, A, G, N, C, D, or F as a primary anchor residue in position 2 and K, R, Y, or H as a primary anchor residue at the C-terminal position. Peptide binding to HLA-A11 can be modulated by substitutions at primary and/or secondary anchor positions.

[0142] Representative peptide epitopes that contain the A11 motif are set forth on the attached Table XVI; peptides bearing the A3 allele-specific motif are also present in Table XVII. The A11 and A3 motifs have a number of anchor residues in common, separate tables would provide a number of redundant entries.

IV.C.2.m) HLA-A24 Motif

[0143] The allele-specific HLA-A24 motif is characterized by the presence in peptide ligands of Y, F, W, or M as a primary anchor residue in position 2 and F, L, I, or W as a primary anchor residue at the C-terminal position. Peptide binding to HLA-A24 molecules can be modulated by substitutions at primary and/or secondary anchor positions.

[0144] Representative peptide epitopes that contain the A24 motif are set forth on the attached Table XVII.

IV.C.2.n) HLA-A2.1 Motif

[0145] The allele-specific HLA-A2.1 motif was first determined to be characterized by the presence in peptide ligands of L, M, V, I, A or T as a primary anchor residue in position 2 and, L, V, I, A, or T as a primary anchor residue at the C-terminal position. The preferred and tolerated residues that characterize the primary anchor positions of the HLA-A2.1 motif are identical to the preferred residue of the A2 supermotif. Secondary anchor residues that characterize the A2.1 motif have additionally been defined as disclosed herein. These are disclosed in Table II. Peptide binding to HLA-A2.1 molecules can be modulated by substitutions at primary and/or secondary anchor positions.

[0146] Representative peptide epitopes that contain the A2.1 motif are set forth on the attached Table VII. These peptides, which bear the HLA-A2 supermotif, also contain secondary anchor residues that are characteristic of the HLA-A2.1 motif. In one embodiment, the peptide epitope does not bear an L or M at position 2 and V at the C-terminal position 9 of a 9-amino acid peptide.

[0147] The primary anchor residues of the HLA class I peptide epitope supermotifs and motifs delineated above are summarized in Table I. Primary and secondary anchor positions are summarized in Table II.

Motifs Indicative of Class II HTL Inducing Peptide Epitopes

IV.C.2.o) HLA DR-1-4-7 Supermotif

[0148] Motifs have also been identified for peptides that bind to three common HLA class II types, HLA DRB1*0401, DRB1*0101, and DRB1*0701. Peptides binding to these DR molecules carry a motif characterized by a large aromatic or hydrophobic residue in position 1 (Y, F, W, L, I, V, or M) and a small, non-charged residue in position 6 (S, T, C, AP, V, I, L, or M). Allele specific secondary effects and secondary anchors for each of these HLA types have also been identified. These are set forth in Table III. Peptide binding to HLA-DR4, DR1, and DR7 can be modulated by substitutions at primary and/or secondary anchor positions.

[0149] Representative peptides are set forth in Table XVIII.

IV.C.2.p) HLA DR3 Motifs

[0150] Two alternative motifs characterize peptides that bind to HLA-DR3 molecules. In the first motif, a large, hydrophobic residue (I, L, V, M, Y, or F) is present in anchor position 1 and D is present as an anchor at position 4, which is defined as being 3 positions from anchor position 1 towards the carboxyl terminus regardless of the location of anchor position 1 in the peptide. Lack of either the large, hydrophobic residue at anchor position 1, or of the negatively charged or amide-like anchor residue at position 4 may be compensated for by the presence of a positive charge at position 6 (which is defined as being 5 positions from anchor position 1 towards the carboxyl terminus). Thus for the second, alternative motif I, L, V, M, Y, F, or A is present at anchor position 1; D, N, Q, E, S, or T is present at anchor position 4; and K, R, or H is present at anchor position 6. Peptide binding to HLA-DR3 can be modulated by substitutions at primary and/or secondary anchor positions.

[0151] Representative peptides are set forth in Table IXX.

IV.C.3. Enhancing Population Coverage of the Vaccine

[0152] Vaccines that have broad population coverage are preferred because they are more commercially viable and generally applicable to the most people. Broad population coverage can be obtained using the peptides of the invention (and nucleic acid compositions that encode such peptides) through selecting peptide epitopes that bind to HLA alleles which, when considered in total, are present in most of the population. Table XX lists the overall frequencies of the A2-, A3-, and B7-supertypes in various ethnicities. Coverage in excess of 80% is achieved with these motifs. These results suggest that effective and non-ethnically biased population coverage is achieved upon use of a limited number of cross-reactive peptides. Although the population coverage reached with these three main peptide specificities is high, coverage can be expanded to reach 95% population coverage and above, and more easily achieve truly multispecific responses upon use of additional supermotif or allele-specific motif bearing peptides.

[0153] Table XX summarizes the HLA supertypes that have been identified, and indicates an estimate of their combined prevalence in major ethnic groups. The B44-, A1-, and A24-supertypes are present, on average, in over 25% of the world's major ethnic populations. While less prevalent overall, the B27-, B58-, and B62 supertypes are each present with a frequency >25% in at least one major ethnic group. The Table indicates the population coverage achieved by the A2-, A3-, and B7-supertypes, and the incremental coverage obtained by the addition of A1-, A24-, and B44-supertypes, or all of the supertypes described herein. As shown, by including epitopes from the six most frequent supertypes, an average population coverage of 99% is obtained for five major ethnic groups.

[0154] The data presented herein, together with the previous definition of the A2-, A3-, and B7-supertypes, indicates that all antigens, with the possible exception of A29, B8, and B46, can be classified into a total of nine HLA supertypes. Focusing on the six most common supertypes affords population coverage greater than 98% for all major ethnic populations.

IV.D. IMMUNE RESPONSE STIMULATING PEPTIDE ANALOGS

[0155] Although peptides with suitable cross-reactivity among all alleles of a superfamily are identified by the screening procedures described above, cross-reactivity is not always complete and in such cases procedures to further increase cross-reactivity of peptides can be useful; such procedures can also be used to modify other properties of the peptides. Having established the general rules that govern cross-reactivity of peptides for HLA alleles within a given motif or supermotif, modification (i.e., analoging) of the structure of peptides of particular interest in order to achieve broader (or otherwise modified) HLA binding capacity can be performed. More specifically, peptides which exhibit the broadest cross-reactivity patterns, (both amongst the known T cell epitopes, as well as the more extended set of peptides that contain the appropriate supermotifs), can be produced in accordance with the teachings herein.

[0156] The strategy employed utilizes the motifs or supermotifs which correlate with binding to certain HLA molecules. The motifs or supermotifs are defined by having primary anchors, though secondary anchors can also be modified. Analog peptides can be created by substituting amino acids residues at primary anchor, secondary anchor, or at primary and secondary anchor positions. Generally, analogs are made for peptides that already bear a motif or supermotif. Preferred secondary anchor residues of supermotifs and motifs that have been defined for HLA class I and class II binding peptides are shown in Tables II and III, respectively.

[0157] For a number of the motifs or supermotifs in accordance with the invention, residues are defined which are deleterious to binding to allele-specific HLA molecules or members of HLA supertypes that bind to the respective motif or supermotif (Tables II and III). Accordingly, removal of residues that are detrimental to binding can be performed in accordance with the present invention. For example, in the case of the A3 supertype, when all peptides that have such deleterious residues are removed from the population of analyzed peptides, the incidence of cross-reactivity increases from 22% to 37% (see, e.g., Sidney, J. et al., Hu. Immunol. 45:79, 1996). Thus, one strategy to improve the cross-reactivity of peptides within a given supermotif is simply to delete one or more of the deleterious residues present within a peptide and substitute a small "neutral" residue such as Ala (that may not influence T cell recognition of the peptide). An enhanced likelihood of cross-reactivity is expected if, together with elimination of detrimental residues within a peptide, residues associated with high affinity binding to multiple alleles within a superfamily are inserted.

[0158] To ensure that changes in the native or original epitope recognized by T cells do not lead to a failure of killing antigen presenting cells presenting the unaltered "wild type" peptide (or, in the case of class II epitopes, a failure to elicit helper T cells that cross-react with the wild type peptides), the variant peptide may be used to immunize T cells in vitro from individuals of the appropriate HLA allele, and the cells' capacity to induce lysis of wild type peptide sensitized target cells is evaluated. In both class I and class II systems it will be desirable to use as targets, cells that have been either infected or transfected with the appropriate genes to establish whether endogenously produced antigen is also recognized by the relevant T cells.

[0159] Another embodiment of the invention to ensure adequate numbers of cross-reactive cellular binders is to create analogs of weak binding peptides. Class I peptides exhibiting binding affinities of 500-50000 nM, and carrying an acceptable but suboptimal primary anchor residue at one or both positions can be "fixed" by substituting preferred anchor residues in accordance with the respective supertype. The analog peptides can then be tested for crossbinding activity.

[0160] Another embodiment for generating effective peptide analogs involves the substitution of residues that have an adverse impact on peptide stability or solubility in a liquid environment. This substitution may occur at any position of the peptide epitope. For example, a cysteine (C) can be substituted out in favor of .alpha.-amino butyric acid. Due to its chemical nature, cysteine has the propensity to form disulfide bridges and sufficiently alter the peptide structurally so as to reduce binding capacity. Substituting .alpha.-amino butyric acid for C not only alleviates this problem, but actually improves binding and crossbinding capability in certain instances (Review: A. Sette et al, In: Persistent Viral Infections, Eds. R. Ahmed and I. Chen, John Wiley & Sons, England, in press, 1998). Substitution of cysteine with .alpha.-amino butyric acid may occur at any residue of a peptide epitope, i.e. at either anchor or non-anchor positions.

[0161] In general, CTL and HTL responses are not directed against all possible epitopes. Rather, they are restricted to a few immunodominant determinants (Zinkernagel, et al., Adv. Immunol. 27:5159, 1979; Bennink, et al., J. Exp. Med. 168:19351939, 1988; Rawle, et al., J. Immunol. 146:3977-3984, 1991). It has been recognized that immunodominance (Benacerraf, et al., Science 175:273-279, 1972) could be explained by either the ability of a given epitope to selectively bind a particular HLA protein (determinant selection theory) (Vitiello, et al., J. Immunol. 131:1635, 1983); Rosenthal, et al., Nature 267:156-158, 1977), or being selectively recognized by the existing TCR (T cell receptor) specificity (repertoire theory) (Klein, J., IMMUNOLOGY, THE SCIENCE OF SELFNONSELF DISCRIMINATION, John Wiley & Sons, New York, pp. 270-310, 1982). It has been demonstrated that additional factors, mostly linked to processing events, can also play a key role in dictating, beyond strict immunogenicity, which of the many potential determinants will be presented as immunodominant (Sercarz, et al., Annu. Rev. Immunol. 11:729-766, 1993).

[0162] The concept of dominance and subdominance is relevant to immunotherapy of both infectious diseases and cancer. For example, in the course of chronic viral disease, recruitment of subdominant epitopes can be important for successful clearance of the infection, especially if dominant CTL or HTL specificities have been inactivated by functional tolerance, suppression, mutation of viruses and other mechanisms (Franco, et al., Curr. Opin. Immunol. 7:524-531, (1995)). In the case of cancer and tumor antigens, CTLs recognizing at least some of the highest binding affinity peptides might be functionally inactivated. Lower binding affinity peptides are preferentially recognized at these times.

[0163] In particular, it has been noted that a significant number of epitopes derived from known non-viral tumor associated antigens (TAA) bind HLA class I with intermediate affinity (IC.sub.50 in the 50-500 nM range). For example, it has been found that 8 of 15 known TAA peptides recognized by tumor infiltrating lymphocytes (TIL) or CTL bound in the 50-500 nM range. (These data are in contrast with estimates that 90% of known viral antigens that were recognized as peptides bound HLA with IC.sub.50 of 50 nM or less, while only approximately 10% bound in the 50-500 nM range (Sette, et al., J. Immunol., 153:558-5592 (1994)). In the cancer setting this phenomenon is probably due to elimination, or functional inhibition of the CTL recognizing several of the highest binding peptides, presumably because of T cell tolerization events.

[0164] Without intending to be bound by theory, it is believed that because T cells to dominant epitopes may have been clonally deleted, selecting subdominant epitopes may allow extant T cells to be recruited, which will then lead to a therapeutic response. However, the binding of HLA molecules to subdominant epitopes is often less vigorous than to dominant ones. Accordingly, there is a need to be able to modulate the binding affinity of particular immunogenic epitopes for one or more HLA molecules, and thereby to modulate the immune response elicited by the peptide. Thus a need exists to prepare analog peptides which elicit a more vigorous response. This ability would greatly enhance the usefulness of peptide-based vaccines and therapeutic agents.

[0165] Representative analog peptides are set forth in Table XXI. The Table indicates the length and sequence of the analog peptide as well as the motif or supermotif, if appropriate. The term "fixed nomenclature" refers to the change

IV.E. COMPUTER SCREENING OF PROTEIN SEQUENCES FROM DISEASE-RELATED ANTIGENS FOR SUPERMOTIF OR MOTIF CONTAINING PEPTIDES

[0166] Computer programs that allow the rapid screening of protein sequences for the occurrence of the subject supermotifs or motifs are encompassed by the present invention; as are programs that permit the generation of analog peptides. These programs are implemented to analyze any identified amino acid sequence or operate on an unknown sequence and simultaneously determine the sequence and identify motif-bearing epitopes thereof; analogs can be simultaneously determined as well. Generally, the identified sequences will be from a pathogenic organism or a tumor-associated peptide. For example, the target molecules considered herein include all of the HBV proteins (e.g. surface, core, polymerase, and X).

[0167] In cases where the sequence of multiple variants of the same target protein are available, peptides are also selected on the basis of their conservancy. A presently preferred criterion for conservancy defines that the entire sequence of a peptide be totally conserved in 75% of the sequences evaluated for a specific protein; this definition of conservancy has been employed herein.

[0168] It is important that the selection criteria utilized for prediction of peptide binding are as accurate as possible, to correlate most efficiently with actual binding. Prediction of peptides that bind, for example, to HLA-A*0201, on the basis of the presence of the appropriate primary anchors, is positive at about a 30% rate (Ruppert, J. et al. Cell 74:929, 1993). However, by analyzing an extensive peptide-HLA binding database, the present inventors have developed a number of allele specific polynomial algorithms that dramatically increase the predictive value over identification on the basis of the presence of primary anchor residues alone. These algorithms take into account not only the presence or absence of the correct primary anchors, but also consider the positive or deleterious presence of secondary anchor residues (to account for the impact of different amino acids at different positions). The algorithms are essentially based on the premise that the overall affinity (or AG) of peptide-HLA interactions can be approximated as a linear polynomial function of the type:

.DELTA.G=a.sub.1i.times.a.sub.2i.times.a.sub.3i . . . .times.a.sub.ni

where a.sub.ij is a coefficient that represents the effect of the presence of a given amino acid (j) at a given position (i) along the sequence of a peptide of n amino acids. An important assumption of this method is that the effects at each position are essentially independent of each other. This assumption is justified by studies that demonstrated that peptides are bound to HLA molecules and recognized by T cells in essentially an extended conformation. Derivation of specific algorithm coefficients has been described in Gulukota et al. (Gulukota, K. et al., J. Mol. Biol. 267:1258, 1997).

[0169] Additional methods to identify preferred peptide sequences, which also make use of specific motifs, include the use of neural networks and molecular modeling programs (Gulukota, K. et al., J. Mol. Biol. 267:1258, 1997; Milik et al., Nature Biotechnology 16:753, 1998; Altuvia et al., Hum. Immunol. 58:1, 1997; Altuvia et al, J. Mol. Biol. 249:244, 1995).

[0170] For example, it has been shown that in sets of A*0201 motif peptides, 69% of the peptides containing at least one preferred secondary anchor residue while avoiding the presence of any deleterious secondary anchor residues, will bind A*0201 with an IC.sub.50 less than 500 nM (Ruppert, J. et al. Cell 74:929, 1993). These algorithms are also flexible in that cut-off scores may be adjusted to select sets of peptides with greater or lower predicted binding properties, as desired.

[0171] In utilizing computer screening to identify peptide epitopes, all protein sequence or translated sequence may be analyzed using software developed to search for motifs, for example the "FINDPATTERNS" program (Devereux, et al. Nucl. Acids Res. 12:387-395, 1984) or MotifSearch 1.4 software program (D. Brown, San Diego, Calif.) to identify potential peptide sequences containing appropriate HLA binding motifs. As appreciated by one of ordinary skill in the art a large array of software and hardware options are available which can be employed to implement the motifs of the invention relative to known or unknown peptide sequences. The identified peptides will then be scored using customized polynomial algorithms to predict their capacity to bind specific HLA class I or class II alleles.

[0172] In accordance with the procedures described above, HBV peptides and analogs thereof that are able to bind HLA supertype groups or allele-specific HLA molecules have been identified (Tables VI-XIX; Table XXI).

IV.F. ASSAYS TO DETECT T-CELL RESPONSES

[0173] Once HLA binding peptides are identified, they can be tested for the ability to elicit a T-cell response. The preparation and evaluation of motif-bearing peptides are described in PCT publications WO 94/20127 and WO 94/03205. Briefly, peptides comprising epitopes from a particular antigen are synthesized and tested for their ability to bind to the appropriate HLA proteins in assays using, for example, purified HLA class I molecules and radioiodonated peptides and/or cells expressing empty class I molecules (which lack peptide in their receptor) by, for instance, immunofluorescent staining and flow microfluorimetry, peptide-dependent class I assembly assays, and inhibition of CTL recognition by peptide competition. Those peptides that bind to the class I molecule are further evaluated for their ability to serve as targets for CTLs derived from infected or immunized individuals, as well as for their capacity to induce primary in vitro or in vivo CTL responses that can give rise to CTL populations capable of reacting with selected target cells associated with a disease. Corresponding assays are used for evaluation of HLA class II binding peptides.

[0174] Conventional assays utilized to detect CTL responses include proliferation assays, lymphokine secretion assays, direct cytotoxicity assays, and limiting dilution assays. For example, antigen-presenting cells that have been incubated with a peptide can be assayed for the ability to induce CTL responses in responder cell populations. Antigen-presenting cells can be normal cells such as peripheral blood mononuclear cells or dendritic cells. Alternatively, mutant mammalian cell lines that are deficient in their ability to load class I molecules with internally processed peptides and that have been transfected with the appropriate human class I gene may be used to test for the capacity of the peptide to induce in vitro primary CTL responses.

[0175] Peripheral blood lymphocytes may be used as the responder cell source of CTL precursors. The appropriate antigen-presenting cells are incubated with peptide and the peptide-loaded antigen-presenting cells are then incubated with the responder cell population under optimized culture conditions. Positive CTL activation can be determined by assaying the culture for the presence of CTLs that kill radio-labeled target cells, both specific peptide-pulsed targets as well as target cells expressing endogenously processed forms of the HBV antigen from which the peptide sequence was derived.

[0176] More recently, a method has also been devised which allows direct quantification of antigen-specific T cells by staining with Fluorescein-labeled HLA tetrameric complexes (Altman, J. D. et al., Proc. Natl. Acad. Sci. USA 90:10330, 1993; Altman, J. D. et al., Science 274:94, 1996). Other relatively recent technical developments include staining for intracellular lymphokines, and interferon release assays or ELISPOT assays. Tetramer staining, intracellular lymphokine staining and ELISPOT assays all appear to be at least 10-fold more sensitive than more conventional assays (Lalvani, A. et al., J. Exp. Med. 186:859, 1997; Dunbar, P. R. et al., Curr. Biol. 8:413, 1998; Murali-Krishna, K. et al., Immunity 8:177, 1998).

[0177] HTL activation may also be assessed using such techniques as T cell proliferation and secretion of lymphokines, e.g. IL-2.

[0178] Alternatively, immunization of HLA transgenic mice can be used to determine immunogenicity of peptide epitopes. Several transgenic mouse models including mice with human A2.1, A11, and B7 alleles have been characterized and others (e.g., transgenic mice for HLA-A1 and A24) are being developed. HLA-DR1 and HLA-DR3 mouse models have also been developed. Additional transgenic mouse models with other HLA alleles may be generated as necessary. Mice may be immunized with peptides emulsified in Incomplete Freund's Adjuvant and the resulting T cells tested for their capacity to recognize peptide-pulsed target cells and target cells transfected with appropriate genes. CTL responses may be analyzed using cytotoxicity assays described above. Similarly, HTL responses may be analyzed using such assays as T cell proliferation or secretion of lymphokines.

IV.G. PREPARATION OF PEPTIDES

[0179] Peptides in accordance with the invention can be prepared synthetically, by recombinant DNA technology, or from natural sources such as native tumors or pathogenic organisms. Peptide epitopes may be synthesized individually or as polyepitopic peptides. Although the peptide will preferably be substantially free of other naturally occurring host cell proteins and fragments thereof, in some embodiments the peptides may be synthetically conjugated to native fragments or particles.

[0180] The peptides in accordance with the invention can be a variety of lengths, and either in their neutral (uncharged) forms or in forms which are salts. Peptides may be synthesized The peptides in accordance with the invention are either free of modifications such as glycosylation, side chain oxidation, or phosphorylation; or they contain these modifications, subject to the condition that modifications do not destroy the biological activity of the peptides as described herein.

[0181] Desirably, the peptide will be as small as possible while still maintaining substantially all of the biological activity of the large peptide. When possible, it may be desirable to optimize HLA class I binding peptides of the invention to a length of about 8 to about 13 amino acid residues, preferably 9 to 10. HLA class II binding peptides may be optimized to a length of about 6 to about 25 amino acids in length, preferably to between about 13 and about 20 residues. Preferably, the peptides are commensurate in size with endogenously processed pathogen-derived peptides or tumor cell peptides that are bound to the relevant HLA molecules. Moreover, the identification and preparation of peptides of other lengths can be carried out using the techniques described herein (e.g., the disclosures regarding primary and secondary anchor positions). However, it is also preferred to identify a larger region of a native peptide that encompasses one and preferably two or more epitopes in accordance with the invention. This sequence is selected on the basis that it contains the greatest number of epitopes per amino acid length. It is to be appreciated that epitopes can be present in a frame-shifted manner, e.g. a 10 amino acid long peptide could contain two 9 amino acid long epitopes and one 10 amino acid long epitope; each epitope can be exposed and bound by an HLA molecule upon administration of a plurality of such peptides. This larger, preferably multi-epitopic, peptide can then be generated synthetically, recombinantly, or via cleavage from the native source.

[0182] The peptides of the invention can be prepared in a wide variety of ways. For the preferred relatively short size, the peptides can be synthesized in solution or on a solid support in accordance with conventional techniques. Various automatic synthesizers are commercially available and can be used in accordance with known protocols. See, for example, Stewart & Young, SOLID PHASE PEPTIDE SYNTHESIS, 2D. ED., Pierce Chemical Co. (1984). Further, individual peptides may be joined using chemical ligation to produce larger peptides.

[0183] Alternatively, recombinant DNA technology may be employed wherein a nucleotide sequence which encodes an immunogenic peptide of interest is inserted into an expression vector, transformed or transfected into an appropriate host cell and cultivated under conditions suitable for expression. These procedures are generally known in the art, as described generally in Sambrook et al., MOLECULAR CLONING, A LABORATORY MANUAL, Cold Spring Harbor Press, Cold Spring Harbor, N.Y. (1989). Thus, recombinant polypeptides which comprise one or more peptide sequences of the invention can be used to present the appropriate T cell epitope.

[0184] As the nucleotide coding sequence for peptides of the preferred lengths contemplated herein can be synthesized by chemical techniques, for example, the phosphotriester method of Matteucci, et al., J. Am. Chem. Soc. 103:3185 (1981) modification can be made simply by substituting the appropriate and desired nucleic acid base(s) for those that encode the native peptide sequence. The coding sequence can then be provided with appropriate linkers and ligated into expression vectors commonly available in the art, and the vectors used to transform suitable hosts to produce the desired fusion protein. A number of such vectors and suitable host systems are now available. For expression of the fusion proteins, the coding sequence will be provided with operably linked start and stop codons, promoter and terminator regions and usually a replication system to provide an expression vector for expression in the desired cellular host. For example, promoter sequences compatible with bacterial hosts are provided in plasmids containing convenient restriction sites for insertion of the desired coding sequence. The resulting expression vectors are transformed into suitable bacterial hosts. Of course, yeast, insect or mammalian cell hosts may also be used, employing suitable vectors and control sequences.

IV.H. PEPTIDE EPITOPE REAGENTS TO EVALUATE IMMUNE RESPONSES

[0185] HLA class I and class II binding peptides as described herein can be used, in one embodiment of the invention, as reagents to evaluate an immune response. The immune response to be evaluated may be induced by using as an immunogen any agent that would potentially result in the production of antigen-specific CTLs or HTLs to the peptide epitope(s) to be employed as the reagent. The peptide reagent is not used as the immunogen.

[0186] For example, a peptide of the invention may be used in a tetramer staining assay to assess peripheral blood mononuclear cells for the presence of antigen-specific CTLs following exposure to a pathogen or immunogen. The HLA-tetrameric complex is used to directly visualize antigen-specific CTLs (see, e.g., Ogg et al. Science 279:2103-2106, 1998; and Altman et al. Science 174:94-96, 1996) and determine the frequency of the antigen-specific CTL population in a sample of peripheral blood mononuclear cells. A tetramer reagent using a peptide of the invention may be generated as follows: A peptide that binds to an allele-specific HLA molecules, or supertype molecules, is refolded in the presence of the corresponding HLA heavy chain and 132-microglobulin to generate a trimolecular complex. The complex is biotinylated at the carboxyl terminal end of the heavy chain at a site that was previously engineered into the protein. Tetramer formation is then induced by the addition of streptavidin. By means of fluorescently labeled streptavidin, the tetramer can be used to stain antigen-specific cells. The cells may then be identified, for example, by flow cytometry. Such an analysis may be used for diagnostic or prognostic purposes.

[0187] Peptides of the invention may also be used as reagents to evaluate immune recall responses. (see, e.g., Bertoni et al. J. Clin. Invest. 100:503-513, 1997 and Penna et al. J. Exp. Med. 174:1565-1570, 1991.) For example, patient PBC samples from individuals with acute hepatitis B or who have recently recovered from acute hepatitis B may be analyzed for the presence of HBV antigen-specific CTLs using HBV-specific peptides. A blood sample containing mononuclear cells may be evaluated by cultivating the PBCs and stimulating the cells with a peptide of the invention. After an appropriate cultivation period, the expanded cell population may be analyzed for cytotoxic activity.

[0188] The peptides may also be used as reagents to evaluate the efficacy of a vaccine. PBMCs obtained from a patient vaccinated with an immunogen may be analyzed using, for example, either of the methods described above. A patient is HLA typed, and appropriate peptide reagents that recognize allele-specific molecules present in that patient may be selected for the analysis. The immunogenicity of the vaccine will be indicated by the presence of HBV epitope-specific CTLs in the PBMC sample.

IV.I. VACCINE COMPOSITIONS

[0189] Vaccines that contain as an active ingredient an immunogenically effective amount of one or more peptides as described herein are a further embodiment of the invention. Once appropriately immunogenic epitopes have been defined, they can be sorted and delivered by various means, herein referred to as "vaccine" compositions. Such vaccine compositions can include, for example, lipopeptides (Vitiello, A. et al., J. Clin. Invest. 95:341, 1995), peptides compositions encapsulated in poly(DL-lactide-co-glycolide) (PLG) microspheres (see, e.g., Eldridge, et al. Molec. Immunol. 28:287-294, 1991: Alonso et al. Vaccine 12:299-306, 1994; Jones et al. Vaccine 13:675-681, 1995), peptide compositions encapsulated in immune stimulating complexes (ISCOMS) (see, e.g., Takahashi et al. Nature 344:873-875, 1990; Hu et al. Clin Exp Immunol. 113:235-243, 1998), multiple antigen peptide systems (MAPs) (see e.g., Tam, J. P., Proc. Natl. Acad. Sci. U.S.A. 85:5409-5413, 1988; Tam, J. P., J. Immunol. Methods 196:17-32, 1996), viral delivery vectors (Perkus, M. E. et al., In: Concepts in vaccine development, Kaufmann, S. H. E., ed., p. 379, 1996; Chakrabarti, S. et al., Nature 320:535, 1986; Hu, S. L. et al., Nature 320:537, 1986; Kieny, M.-P. et al., AIDS Bio/Technology 4:790, 1986; Top, F. H. et al., J. Infect. Dis. 124:148, 1971; Chanda, P. K. et al., Virology 175:535, 1990), particles of viral or synthetic origin (Kofler, N. et al., J. Immunol. Methods. 192:25, 1996; Eldridge, J. H. et al., Sem. Hematol. 30:16, 1993; Falo, L. D., Jr. et al., Nature Med. 7:649, 1995), adjuvants (Warren, H. S., Vogel, F. R., and Chedid, L. A. Annu. Rev. Immunol. 4:369, 1986; Gupta, R. K. et al., Vaccine 11:293, 1993), liposomes (Reddy, R. et al., J. Immunol. 148:1585, 1992; Rock, K. L., Immunol. Today 17:131, 1996), or, naked or particle absorbed cDNA (Ulmer, J. B. et al., Science 259:1745, 1993; Robinson, H. L., Hunt, L. A., and Webster, R. G., Vaccine 11:957, 1993; Shiver, J. W. et al., In: Concepts in vaccine development, Kaufmann, S. H. E., ed., p. 423, 1996; Cease, K. B., and Berzofsky, J. A., Annu. Rev. Immunol. 12:923, 1994 and Eldridge, J. H. et al., Sem. Hematol. 30:16, 1993). Toxin-targeted, also know as receptor mediated targeting, delivery technologies also may be used such as those of Avant Immunotherapeutics, Inc. (Needham, Mass.).

[0190] Furthermore, vaccines in accordance with the invention encompass compositions of one or more of the claimed peptide(s) that can be introduced into a host, including humans, linked to its own carrier, or as a homopolymer or heteropolymer of active peptide units. Such a polymer has the advantage of increased immunological reaction and, where different peptides are used to make up the polymer, the additional ability to induce antibodies and/or CTLs that react with different antigenic determinants of the pathogenic organism or tumor-related peptide targeted for an immune response.

[0191] Furthermore, useful carriers that can be used with vaccines of the invention are well known in the art, and include, e.g., thyroglobulin, albumins such as human serum albumin, tetanus toxoid, polyamino acids such as poly L-lysine, poly L-glutamic acid, influenza, hepatitis B virus core protein, hepatitis B virus recombinant vaccine and the like. The vaccines can contain a physiologically tolerable (i.e., acceptable) diluent such as water, or saline, preferably phosphate buffered saline. The vaccines also typically include an adjuvant. Adjuvants such as incomplete Freund's adjuvant, aluminum phosphate, aluminum hydroxide, or alum are examples of materials well known in the art. Additionally, as disclosed herein, CTL responses can be primed by conjugating peptides of the invention to lipids, such as tripalmitoyl-S-glycerylcysteinlyseryl-serine (P.sub.3CSS).

[0192] As disclosed in greater detail herein, upon immunization with a peptide composition in accordance with the invention, via injection, aerosol, oral, transdermal, transmucosal, intrapleural, intrathecal, or other suitable routes, the immune system of the host responds to the vaccine by producing large amounts of CTLs specific for the desired antigen, and the host becomes at least partially immune to later infection, or at least partially resistant to developing an ongoing chronic infection.

[0193] In some instances it may be desirable to combine the class I peptide vaccines of the invention with vaccines which induce or facilitate neutralizing antibody responses to the target antigen of interest, particularly to viral envelope antigens. A preferred embodiment of such a composition comprises class I and class II epitopes in accordance with the invention. An alternative embodiment of such a composition comprises a class I and/or class II epitope in accordance with the invention, along with a PADRE.RTM. (Epimmune, San Diego, Calif.) molecule (described in the related U.S. Ser. No. 08/485,218, which is a CIP of U.S. Ser. No. 08/305,871, now U.S. Pat. No. 5,736,142, which is a CIP of abandoned application U.S. Ser. No. 08/121,101.) Furthermore, any of these embodiments can be administered as a nucleic acid mediated modality.

[0194] For therapeutic or immunization purposes, the peptides of the invention can also be expressed by viral or bacterial vectors. Examples of expression vectors include attenuated viral hosts, such as vaccinia or fowlpox. This approach involves the use of vaccinia virus as a vector to express nucleotide sequences that encode the peptides of the invention. Upon introduction into an acutely or chronically infected host or into a non-infected host, the recombinant vaccinia virus expresses the immunogenic peptide, and thereby elicits a host CTL and/or HTL response. Vaccinia vectors and methods useful in immunization protocols are described in, e.g., U.S. Pat. No. 4,722,848. Another vector is BCG (Bacille Calmette Guerin). BCG vectors are described in Stover, et al. Nature 351:456-460 (1991). A wide variety of other vectors useful for therapeutic administration or immunization of the peptides of the invention, e.g. adeno and adeno-associated virus vectors, retroviral vectors, Salmonella typhi vectors, detoxified anthrax toxin vectors, and the like, will be apparent to those skilled in the art from the description herein.

[0195] Antigenic peptides are used to elicit a CTL and/or HTL response ex vivo, as well. The resulting CTL or HTL cells, can be used to treat chronic infections, or tumors in patients that do not respond to other conventional forms of therapy, or will not respond to a therapeutic vaccine peptide or nucleic acid in accordance with the invention. Ex vivo CTL or HTL responses to a particular pathogen (infectious agent or tumor antigen) are induced by incubating in tissue culture the patient's CTL or HTL precursor cells together with a source of antigen-presenting cells (APC), such as dendritic cells, and the appropriate immunogenic peptide. After an appropriate incubation time (typically about 14 weeks), in which the precursor cells are activated, mature and expand into effector cells, the cells are infused back into the patient, where they will destroy (CTL) or facilitate destruction (HTL) of their specific target cell (an infected cell or a tumor cell). Transfected dendritic cells may also be used as antigen presenting cells. Alternatively, dendritic cells are transfected, e.g., with a minigene construct in accordance with the invention, in order to elicit immune responses. Minigenes will be discussed in greater detail in a following section.

[0196] DNA or RNA encoding one or more of the peptides of the invention can also be administered to a patient. This approach is described, for instance, in Wolff et. al., Science 247:1465 (1990) as well as U.S. Pat. Nos. 5,580,859; 5,589,466; 5,804,566; 5,739,118; 5,736,524; 5,679,647; WO 98/04720; and in more detail below. Examples of DNA-based delivery technologies include "naked DNA", facilitated (bupivicaine, polymers, peptide-mediated) delivery, cationic lipid complexes, and particle-mediated ("gene gun") delivery.

[0197] Preferably, the following principles are utilized when selecting an array of epitopes for inclusion in a polyepitopic composition, or for selecting epitopes to be included in a vaccine composition and/or to be encoded by a minigene. It is preferred that each of the following principles are balanced in order to make the selection.

[0198] 1.) Epitopes are selected which, upon administration, mimic immune responses that have been observed to be correlated with HBV clearance. For HLA Class I this includes 3-4 epitopes that come from at least one antigen of HBV. In other words, it has been observed that in patients who spontaneously clear HBV, that they had generated an immune response to at least 3 epitopes on at least one HBV antigen. For HLA Class II a similar rationale is employed; again 3-4 epitopes are selected from at least one HBV antigen (see e.g., Rosenberg et al. Science 278:1447-1450).

[0199] 2.) Epitopes are selected that have the requisite binding affinity established to be correlated with immunogenicity: for HLA Class I an IC.sub.50 of 500 nM or less, or for Class II an IC.sub.50 of 1000 nM or less.

[0200] 3.) Sufficient supermotif bearing peptides, or a sufficient array of allele-specific motif bearing peptides, are selected to give broad population coverage. For example, it is preferable to have at least 80% population coverage. A Monte Carlo analysis, a statistical evaluation known in the art, can be employed to assess population coverage.

[0201] 4.) When selecting epitopes from cancer-related antigens it is often preferred to select analogs. When selecting epitopes for infectious disease-related antigens it is often preferable to select native epitopes. Therefore, of particular relevance for infectious disease vaccines (but for cancer-related vaccines as well), are epitopes referred to as "nested epitopes." Nested epitopes occur where at least two epitopes overlap in a given peptide sequence. A peptide comprising "transcendent nested epitopes" is a peptide that has both HLA class I and HLA class II epitopes in it.

[0202] When providing nested epitopes, it is preferable to provide a sequence that has the greatest number of epitopes per provided sequence. A limitation on this principle is to avoid providing a peptide that is any longer than the amino terminus of the amino terminal epitope and the carboxyl terminus of the carboxyl terminal epitope in the peptide. When providing a longer peptide sequence, such as a sequence comprising nested epitopes, it is important to screen the sequence in order to insure that it does not have pathological or other deleterious biological properties.

[0203] 5.) When creating a minigene, as disclosed in greater detail in the following section, an objective is to generate the smallest peptide possible that encompasses the epitopes of interest. The principles employed are similar, if not the same as those employed when selecting a peptide comprising nested epitopes. Thus, upon determination of the nucleic acid sequence to be provided as a minigene, the peptide encoded thereby is analyzed to determine whether any "junctional epitopes" have been created. A junctional epitope is an actual binding epitope, as predicted, e.g., by motif analysis. Junctional epitopes are to be avoided because the recipient may generate an immune response to that epitope. Of particular concern is a junctional epitope that is a "dominant epitope." A dominant epitope may lead to such a zealous response that immune responses to other epitopes are diminished or suppressed.

IV.I.1. Minigene Vaccines

[0204] A growing body of experimental evidence demonstrates that a number of different approaches are available which allow simultaneous delivery of multiple epitopes. Nucleic acids encoding the peptides of the invention are a particularly useful embodiment of the invention. Epitopes for inclusion in a minigene are preferably selected according to the guidelines above. A preferred means of administering nucleic acids encoding the peptides of the invention uses minigene constructs encoding one or multiple epitopes of the invention. The use of multi-epitope minigenes is described below and in, e.g. An, L. and Whitton, J. L., J. Virol. 71:2292, 1997; Thomson, S. A. et al., J. Immunol. 157:822, 1996; Whitton, J. L. et al., J. Virol. 67:348, 1993; Hanke, R. et al., Vaccine 16:426, 1998. For example, a multi-epitope DNA plasmid encoding nine dominant HLA-A*0201- and A11-restricted epitopes derived from the polymerase, envelope, and core proteins of HBV and HIV, the PADRE.RTM. universal helper T cell (HTL) epitope, and an ER-translocating signal sequence was engineered. Immunization of HLA transgenic mice with this plasmid construct resulted in strong CTL induction responses against the nine epitopes tested, similar to those observed with a lipopeptide of known immunogenicity in humans, and significantly greater than immunization in oil-based adjuvants. Moreover, the immunogenicity of DNA-encoded epitopes in vivo correlated with the in vitro responses of specific CTL lines against target cells transfected with the DNA plasmid.

[0205] For example, to create a DNA sequence encoding the selected epitopes (minigene) for expression in human cells, the amino acid sequences of the epitopes may be reverse translated. A human codon usage table can be used to guide the codon choice for each amino acid. These epitope-encoding DNA sequences may be directly adjoined, so that when translated, a continuous polypeptide sequence is created. To optimize expression and/or immunogenicity, additional elements can be incorporated into the minigene design. Examples of amino acid sequences that could be reverse translated and included in the minigene sequence include: HLA class I epitopes, HLA class II epitopes, a ubiquitination signal sequence, a leader sequence, and/or an endoplasmic reticulum targeting signal. In addition, HLA presentation of CTL and HTL epitopes may be improved by including synthetic (e.g. poly-alanine) or naturally-occurring flanking sequences adjacent to the CTL or HTL epitopes.

[0206] The minigene sequence may be converted to DNA by assembling oligonucleotides that encode the plus and minus strands of the minigene. Overlapping oligonucleotides (30-100 bases long) may be synthesized, phosphorylated, purified and annealed under appropriate conditions using well known techniques. The ends of the oligonucleotides can be joined, for example, using T4 DNA ligase. This synthetic minigene, encoding the epitope polypeptide, can then be cloned into a desired expression vector.

[0207] Standard regulatory sequences well known to those of skill in the art are preferably included in the vector to ensure expression in the target cells. Several vector elements are desirable: a promoter with a down-stream cloning site for minigene insertion; a polyadenylation signal for efficient transcription termination; an E. coli origin of replication; and an E. coli selectable marker (e.g. ampicillin or kanamycin resistance). Numerous promoters can be used for this purpose, e.g., the human cytomegalovirus (hCMV) promoter. See, e.g., U.S. Pat. Nos. 5,580,859 and 5,589,466 for other suitable promoter sequences.

[0208] Additional vector modifications may be desired to optimize minigene expression and immunogenicity. In some cases, introns are required for efficient gene expression, and one or more synthetic or naturally-occurring introns could be incorporated into the transcribed region of the minigene. The inclusion of mRNA stabilization sequences and sequences for replication in mammalian cells may also be considered for increasing minigene expression.

[0209] Once an expression vector is selected, the minigene is cloned into the polylinker region downstream of the promoter. This plasmid is transformed into an appropriate E. coli strain, and DNA is prepared using standard techniques. The orientation and DNA sequence of the minigene, as well as all other elements included in the vector, are confirmed using restriction mapping and DNA sequence analysis. Bacterial cells harboring the correct plasmid can be stored as a master cell bank and a working cell bank.

[0210] In addition, immunostimulatory sequences (ISSs or CpGs) appear to play a role in the immunogenicity of DNA vaccines. These sequences may be included in the vector, outside the minigene coding sequence, if desired to enhance immunogenicity.

[0211] In some embodiments, a bi-cistronic expression vector which allows production of both the minigene-encoded epitopes and a second protein (included to enhance or decrease immunogenicity) can be used. Examples of proteins or polypeptides that could beneficially enhance the immune response if co-expressed include cytokines (e.g., IL-2, IL-12, GM-CSF), cytokine-inducing molecules (e.g., LeIF) or costimulatory molecules. Helper (HTL) epitopes can be joined to intracellular targeting signals and expressed separately from expressed CTL epitopes; this allows direction of the HTL epitopes to a cell compartment different than that of the CTL epitopes. If required, this could facilitate more efficient entry of HTL epitopes into the HLA class II pathway, thereby improving CTL induction. In contrast to HTL or CTL induction, specifically decreasing the immune response by co-expression of immunosuppressive molecules (e.g. TGF-.beta.) may be beneficial in certain diseases).

[0212] Therapeutic quantities of plasmid DNA can be produced for example, by fermentation in E. coli, followed by purification. Aliquots from the working cell bank are used to inoculate growth medium, and grown to saturation in shaker flasks or a bioreactor according to well known techniques. Plasmid DNA can be purified using standard bioseparation technologies such as solid phase anion-exchange resins supplied by QIAGEN, Inc. (Valencia, Calif.). If required, supercoiled DNA can be isolated from the open circular and linear forms using gel electrophoresis or other methods.

[0213] Purified plasmid DNA can be prepared for injection using a variety of formulations. The simplest of these is reconstitution of lyophilized DNA in sterile phosphate-buffer saline (PBS). This approach, known as "naked DNA," is currently being used for intramuscular (IM) administration in clinical trials. To maximize the immunotherapeutic effects of minigene DNA vaccines, an alternative method for formulating purified plasmid DNA may be desirable. A variety of methods have been described, and new techniques may become available. Cationic lipids can also be used in the formulation (see, e.g., as described by WO 93/24640; Mannino & Gould-Fogerite, BioTechniques 6(7): 682 (1988); U.S. Pat. No. 5,279,833; WO 91/06309; and Felgner, et al., Proc. Nat'l Acad. Sci. USA 84:7413 (1987). In addition, glycolipids, fusogenic liposomes, peptides and compounds referred to collectively as protective, interactive, non-condensing (PINC) could also be complexed to purified plasmid DNA to influence variables such as stability, intramuscular dispersion, or trafficking to specific organs or cell types.

[0214] Target cell sensitization can be used as a functional assay for expression and HLA class I presentation of minigene-encoded CTL epitopes, respectively. For example, the plasmid DNA is introduced into a mammalian cell line that is suitable as a target for standard CTL chromium release assays. The transfection method used will be dependent on the final formulation. Electroporation can be used for "naked" DNA, whereas cationic lipids allow direct in vitro transfection. A plasmid expressing green fluorescent protein (GFP) can be co-transfected to allow enrichment of transfected cells using fluorescence activated cell sorting (FACS). These cells are then chromium-51 (.sup.51Cr) labeled and used as target cells for epitope-specific CTL lines; cytolysis, detected by .sup.51Cr release, indicates production of HLA presentation of minigene-encoded CTL epitopes.

[0215] In vivo immunogenicity is a second approach for functional testing of minigene DNA formulations. Transgenic mice expressing appropriate human HLA proteins are immunized with the DNA product. The dose and route of administration are formulation dependent (e.g., IM for DNA in PBS, IP for lipid-complexed DNA). Twenty-one days after immunization, splenocytes are harvested and restimulated for 1 week in the presence of peptides encoding each epitope being tested. For CTL effector cells, assays are conducted for cytolysis of peptide-loaded, chromium-51 labeled target cells using standard techniques. Lysis of target cells sensitized by HLA loading of peptides corresponding to minigene-encoded epitopes demonstrates DNA vaccine function for in vivo induction of CTLs.

[0216] Alternatively, the nucleic acids can be administered using ballistic delivery as described, for instance, in U.S. Pat. No. 5,204,253. Using this technique, particles comprised solely of DNA are administered. In a further alternative embodiment, DNA can be adhered to particles, such as gold particles.

IV.I.2. Combinations with Helper Peptides

[0217] The peptides of the present invention, or analogs thereof, which have immunostimulatory activity may be modified to provide desired attributes, such as improved serum half life, or to enhance immunogenicity.

[0218] For instance, the ability of the peptides to induce CTL activity can be enhanced by linking the peptide to a sequence which contains at least one epitope that is capable of inducing a T helper cell response. Particularly preferred immunogenic peptides/T helper conjugates are linked by a spacer molecule. The spacer is typically comprised of relatively small, neutral molecules, such as amino acids or amino acid mimetics, which are substantially uncharged under physiological conditions. The spacers are typically selected from, e.g., Ala, Gly, or other neutral spacers of nonpolar amino acids or neutral polar amino acids. It will be understood that the optionally present spacer need not be comprised of the same residues and thus may be a hetero- or homo-oligomer. When present, the spacer will usually be at least one or two residues, more usually three to six residues. Alternatively, the CTL peptide may be linked to the T helper peptide without a spacer.

[0219] The immunogenic peptide may be linked to the T helper peptide either directly or via a spacer either at the amino or carboxy terminus of the CTL peptide. The amino terminus of either the immunogenic peptide or the T helper peptide may be acylated. The T helper peptides used in the invention can be modified in the same manner as CTL peptides. For instance, they may be modified to include D-amino acids or be conjugated to other molecules such as lipids, proteins, sugars and the like. Exemplary T helper peptides include tetanus toxoid 830-843, influenza 307-319, and malarial circumsporozoite 382-398 and 378-389.

[0220] In certain embodiments, the T helper peptide is one that is recognized by T helper cells present in the majority of the population. This can be accomplished by selecting amino acid sequences that bind to many, most, or all of the HLA class II molecules. These are known as "loosely HLA-restricted" or "promiscuous" T helper sequences. Examples of amino acid sequences that are promiscuous include sequences from antigens such as tetanus toxoid at positions 830-843 (QYIKANSKFIGITE; SEQ ID NO:2572), Plasmodium falciparum CS protein at positions 378-398 (DIEKKIAKMEKASSVFNVVNS; SEQ ID NO:2573), and Streptococcus 18 kD protein at positions 116 (GAVDSILGGVATYGAA; SEQ ID NO:2574). Other examples include peptides bearing a DR 1-4-7 supermotif.

[0221] Alternatively, it is possible to prepare synthetic peptides capable of stimulating T helper lymphocytes, in a loosely HLA-restricted fashion, using amino acid sequences not found in nature (see, e.g., PCT publication WO 95/07707). These synthetic compounds called Pan-DR-binding epitopes (e.g., PADRE.RTM., Epimmune, Inc., San Diego, Calif.) are designed on the basis of their binding activity to most HLA-DR (human HLA class II) molecules. For instance, a pan-DR-binding epitope peptide having the formula: aKXVWANTLKAAa, where "X" is either cyclohexylalanine, phenylalanine, or tyrosine, and a is either D-alanine or L-alanine (SEQ ID NO:2575), has been found to bind to most HLA-DR alleles, and to stimulate the response of T helper lymphocytes from most individuals, regardless of their HLA type.

[0222] T helper epitopes can also be modified to alter their biological properties. For example, peptides presenting T helper epitopes can contain D-amino acids to increase their resistance to proteases and thus extend their serum half-life. Also, the epitope peptides of the invention can be conjugated to other molecules such as lipids, proteins or sugars, or any other synthetic compounds, to increase their biological activity. Specifically, the T helper peptide can be conjugated to one or more palmitic acid chains at either the amino or carboxyl termini.

[0223] In some embodiments it may be desirable to include in the pharmaceutical compositions of the invention at least one component which primes cytotoxic T lymphocytes. Lipids have been identified as agents capable of priming CTL in vivo against viral antigens. For example, palmitic acid residues can be attached to the .epsilon.- and .alpha.-amino groups of a lysine residue and then linked, e.g., via one or more linking residues such as Gly, Gly-Gly-, Ser, Ser-Ser, or the like, to an immunogenic peptide. The lipidated peptide can then be administered either directly in a micelle or particle, incorporated into a liposome, or emulsified in an adjuvant, e.g., incomplete Freund's adjuvant. In a preferred embodiment, a particularly effective immunogenic comprises palmitic acid attached to .epsilon.- and .alpha.-amino groups of Lys, which is attached via linkage, e.g., Ser-Ser, to the amino terminus of the immunogenic peptide.

[0224] As another example of lipid priming of CTL responses, E. coli lipoproteins, such as tripalmitoyl-S-glycerylcysteinlyseryl-serine (P.sub.3CSS) can be used to prime virus specific CTL when covalently attached to an appropriate peptide. See, Deres, et al., Nature 342:561 (1989). Peptides of the invention can be coupled to P.sub.3CSS, for example, and the lipopeptide administered to an individual to specifically prime a CTL response to the target antigen. Moreover, because the induction of neutralizing antibodies can also be primed with P.sub.3CSS-conjugated epitopes, two such compositions can be combined to more effectively elicit both humoral and cell-mediated responses to infection.

[0225] In addition, additional amino acids can be added to the termini of a peptide to provide for ease of linking peptides one to another, for coupling to a carrier support, or larger peptide, for modifying the physical or chemical properties of the peptide or oligopeptide, or the like. Amino acids such as tyrosine, cysteine, lysine, glutamic or aspartic acid, or the like, can be introduced at the C- or N-terminus of the peptide or oligopeptide, particularly class I peptides. However, it is to be noted that modification at the carboxyl terminus may, in some cases, alter binding characteristics of the peptide. In addition, the peptide or oligopeptide sequences can differ from the natural sequence by being modified by terminal-NH.sub.2 acylation, e.g., by alkanoyl (C.sub.1-C.sub.20) or thioglycolyl acetylation, terminal-carboxyl amidation, e.g., ammonia, methylamine, etc. In some instances these modifications may provide sites for linking to a support or other molecule.

IV.J. ADMINISTRATION OF VACCINES FOR THERAPEUTIC OR PROPHYLACTIC PURPOSES

[0226] The peptides of the present invention and pharmaceutical and vaccine compositions of the invention are useful for administration to mammals, particularly humans, to treat and/or prevent HBV infection. Vaccine compositions containing the peptides of the invention are administered to a patient susceptible to or otherwise at risk for HBV infection to elicit an immune response against HBV antigens and thus enhance the patient's own immune response capabilities. In therapeutic applications, compositions are administered to a patient in an amount sufficient to elicit an effective CTL response to the virus or tumor antigen and to cure or at least partially arrest or slow symptoms and/or complications. An amount adequate to accomplish this is defined as "therapeutically effective dose." Amounts effective for this use will depend on, e.g., the particular composition administered, the manner of administration, the stage and severity of the disease being treated, the weight and general state of health of the patient, and the judgment of the prescribing physician. Generally the dosage range for an initial immunization (i.e., therapeutic or prophylactic administration) is between about 1.0 .mu.g to about 5000 .mu.g of peptide, typically between about 10 .mu.g to about 1000 mg, for a 70 kg patient, followed by boosting dosages of between about 1.0 .mu.g to about 5000 .mu.g of peptide pursuant to a boosting regimen over weeks to months depending upon the patient's response and condition as determined by measuring specific CTL activity in the patient's blood. The peptides and compositions of the present invention may be employed in serious disease states, that is, life-threatening or potentially life threatening situations. In such cases, as a result of the minimal amounts of extraneous substances and the relative nontoxic nature of the peptides in preferred compositions of the invention, it is possible and may be felt desirable by the treating physician to administer substantial excesses of these peptide compositions relative to these stated dosage amounts.

[0227] As noted above, the "CTL" peptides of the invention induce immune responses when contacted with a CTL specific to an epitope comprised by the peptide. The manner in which the peptide is contacted with the CTL is not critical to the invention. For instance, the peptide can be contacted with the CTL either in vivo or in vitro. If the contacting occurs in vivo, the peptide itself can be administered to the patient, or other vehicles, e.g., DNA vectors encoding one or more peptides, viral vectors encoding the peptide(s), liposomes and the like, can be used, as described herein.

[0228] For pharmaceutical compositions, the immunogenic peptides, or DNA encoding them, are generally administered to an individual already infected with HBV. The peptides or DNA encoding them can be administered individually or as fusions of one or more peptide sequences. Those in the incubation phase or the acute phase of infection can be treated with the immunogenic peptides separately or in conjunction with other treatments, as appropriate.

[0229] For therapeutic use, administration should generally begin at the first diagnosis of HBV infection. This is followed by boosting doses until at least symptoms are substantially abated and for a period thereafter. In chronic infection, loading doses followed by boosting doses may be required.

[0230] Treatment of an infected individual with the compositions of the invention may hasten resolution of the infection in acutely infected individuals. For those individuals susceptible (or predisposed) to developing chronic infection, the compositions are particularly useful in methods for preventing the evolution from acute to chronic infection. Where susceptible individuals are identified prior to or during infection, the composition can be targeted to them, minimizing need for administration to a larger population.

[0231] The peptide or other compositions as used for the treatment of chronic HBV infection and to stimulate the immune system to eliminate pathogen-infected cells in, e.g., persons who have not manifested symptoms of disease but who act as a disease vector. In this context, it is generally important to provide an amount of immuno-potentiating peptide in a formulation and mode of administration sufficient to effectively stimulate a cytotoxic T cell response; compositions which stimulate helper T cell responses can also be given in accordance with this embodiment of the invention. Thus, for treatment of chronic infection, a representative dose is in the range of about 1.0 .mu.g to about 5000 .mu.g, preferably about 10 .mu.g to 1000 .mu.g, per 70 kg patient weight per dose. Immunizing doses followed by boosting doses at established intervals, e.g., from four weeks to six months, may be required, possibly for a prolonged period of time to effectively immunize an individual. In the case of chronic infection, administration should continue until at least clinical symptoms or laboratory tests indicate that the viral infection has been eliminated or substantially abated and for a period thereafter. The dosages, routes of administration, and dose schedules are adjusted in accordance with methodologies known in the art.

[0232] The pharmaceutical compositions for therapeutic treatment are intended for parenteral, topical, oral, intrathecal, or local administration. Preferably, the pharmaceutical compositions are administered parentally, e.g., intravenously, subcutaneously, intradermally, or intramuscularly. Thus, the invention provides compositions for parenteral administration which comprise a solution of the immunogenic peptides dissolved or suspended in an acceptable carrier, preferably an aqueous carrier. A variety of aqueous carriers may be used, e.g., water, buffered water, 0.8% saline, 0.3% glycine, hyaluronic acid and the like. These compositions may be sterilized by conventional, well known sterilization techniques, or may be sterile filtered. The resulting aqueous solutions may be packaged for use as is, or lyophilized, the lyophilized preparation being combined with a sterile solution prior to administration. The compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions, such as pH-adjusting and buffering agents, tonicity adjusting agents, wetting agents, preservatives, and the like, for example, sodium acetate, sodium lactate, sodium chloride, potassium chloride, calcium chloride, sorbitan monolaurate, triethanolamine oleate, etc.

[0233] The concentration of peptides of the invention in the pharmaceutical formulations can vary widely, i.e., from less than about 0.1%, usually at or at least about 2% to as much as 20% to 50% or more by weight, and will be selected primarily by fluid volumes, viscosities, etc., in accordance with the particular mode of administration selected.

[0234] The peptides of the invention may also be administered via liposomes, which serve to target the peptides to a particular tissue, such as lymphoid tissue, or targeted selectively to infected cells, as well as increase the half-life of the peptide composition. Liposomes include emulsions, foams, micelles, insoluble monolayers, liquid crystals, phospholipid dispersions, lamellar layers and the like. In these preparations the peptide to be delivered is incorporated as part of a liposome, alone or in conjunction with a molecule which binds to, e.g., a receptor prevalent among lymphoid cells, such as monoclonal antibodies which bind to the CD45 antigen, or with other therapeutic or immunogenic compositions. Thus, liposomes either filled or decorated with a desired peptide of the invention can be directed to the site of lymphoid cells, where the liposomes then deliver the peptide compositions. Liposomes for use in the invention are formed from standard vesicle-forming lipids, which generally include neutral and negatively charged phospholipids and a sterol, such as cholesterol. The selection of lipids is generally guided by consideration of, e.g., liposome size, acid lability and stability of the liposomes in the blood stream. A variety of methods are available for preparing liposomes, as described in, e.g., Szoka, et al., Ann. Rev. Biophys. Bioeng. 9:467 (1980), U.S. Pat. Nos. 4,235,871, 4,501,728, 4,837,028, and 5,019,369.

[0235] For targeting cells of the immune system, a ligand to be incorporated into the liposome can include, e.g., antibodies or fragments thereof specific for cell surface determinants of the desired immune system cells. A liposome suspension containing a peptide may be administered intravenously, locally, topically, etc. in a dose which varies according to, inter alia, the manner of administration, the peptide being delivered, and the stage of the disease being treated.

[0236] For solid compositions, conventional nontoxic solid carriers may be used which include, for example, pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharin, talcum, cellulose, glucose, sucrose, magnesium carbonate, and the like. For oral administration, a pharmaceutically acceptable nontoxic composition is formed by incorporating any of the normally employed excipients, such as those carriers previously listed, and generally 10-95% of active ingredient, that is, one or more peptides of the invention, and more preferably at a concentration of 25%-75%.

[0237] For aerosol administration, the immunogenic peptides are preferably supplied in finely divided form along with a surfactant and propellant. Typical percentages of peptides are 0.01%-20% by weight, preferably 1%-10%. The surfactant must, of course, be nontoxic, and preferably soluble in the propellant. Representative of such agents are the esters or partial esters of fatty acids containing from 6 to 22 carbon atoms, such as caproic, octanoic, lauric, palmitic, stearic, linoleic, linolenic, olesteric and oleic acids with an aliphatic polyhydric alcohol or its cyclic anhydride. Mixed esters, such as mixed or natural glycerides may be employed. The surfactant may constitute 0.1%-20% by weight of the composition, preferably 0.25-5%. The balance of the composition is ordinarily propellant. A carrier can also be included, as desired, as with, e.g., lecithin for intranasal delivery.

[0238] The vaccine compositions of the invention may also be used purely as prophylactic agents. Vaccine compositions containing the peptide epitopes of the invention are administered to a patient susceptible to, or otherwise at risk for, HBV infection to elicit an immune response against HBV antigens and thus enhance the patient's own immune response capabilities following exposure to HBV. Generally the dosage range for an initial prophylactic immunization is between about 1.0 .mu.g to about 5000 .mu.g of peptide, typically between about 10 .mu.g to about 1000 .mu.g, for a 70 kg patient. This is followed by boosting dosages of between about 1.0 .mu.g to about 5000 .mu.g of peptide administered at defined intervals from about four weeks to six months after the initial administration of vaccine. The immunogenicity of the vaccine may be assessed by measuring specific CTL activity in the patient's blood.

IV.K. KITS

[0239] The peptide and nucleic acid compositions of this invention can be provided in kit form together with instructions for vaccine administration. Typically the kit would include desired peptide compositions in a container, preferably in unit dosage form and instructions for administration. An alternative kit would include a minigene construct with desired nucleic acids of the invention in a container, preferably in unit dosage form together with instruction for administration. Lymphokines such as IL-2 or IL-12 may also be included in the kit. Other kit components that may also be desirable include, for example, a sterile syringe, booster dosages, and other desired excipients.

[0240] The invention will be described in greater detail by way of specific examples. The following examples are offered for illustrative purposes, and are not intended to limit the invention in any manner. Those of skill in the art will readily recognize a variety of non-critical parameters that can be changed or modified to yield alternative embodiments in accordance with the invention.

V. EXAMPLES

Example 1

HLA Class I Binding Assays

[0241] The following example of peptide binding to HLA-A3 supertype molecules demonstrates quantification of binding affinities of HLA class I peptides. Analogous binding assays can be performed for other peptides that bind class I or class II HLA molecules. Furthermore, binding assays can be performed with peptides that are not motif-bearing.

[0242] For example, the affinity of peptides bearing an HLA-A3 supermotif was determined as follows. Epstein-Barr virus (EBV)-transformed homozygous cell lines were used as sources of class I molecules. Cell lines include, e.g., GM3107 (A3, B7; Human Genetic Mutant Repository); BVR (A11, B35.3, Cw4; Human Genetic Mutant Repository); SPACH (A31, B62, Cw1/3; ASHI Repository Collection); LWAGS (A*3301, B14, and Cw8; ASHI Repository Collection) (Bodmer, et al., Hum. Immunol. 43:149, 1995), and a C1R transfectant characterized by Dr. Walter Storkus (University of Pittsburgh) for the isolation of A*6801. Cell lines were maintained as previously described (Sidney, et al., J. Immunol. 154:247 (1995); Sette, et al., Mol. Immunol. 31:813 (1994)).

[0243] Cell lysates were prepared and HLA class I molecules purified in accordance with disclosed protocols (Sidney, et al., J. Immunol. 154:247 (1995); Sette, et al., Mol. Immunol. 31:813 (1994)). Briefly, cells were lysed at a concentration of 10.sup.8 cells/ml in 50 mM Tris-HCl, pH 8.5, containing 1% Nonidet P-40 (Fluka Biochemika, Buchs, Switzerland), 150 mM NaCl, 5 mM EDTA, and 2 mM PMSF. The lysates were passed through 0.45 .mu.M filters and cleared of nuclei and debris by centrifugation at 10,000 g for 20 minutes. HLA proteins were then purified by affinity chromatography. Columns of inactivated Sepharose CL 4B and Protein A Sepharose were used as precolumns. The cell lysate was depleted of HLA-B and HLA-C proteins by repeated passage over Protein A Sepharose beads conjugated with the anti-HLA(B,C) antibody B1.23.2 (Rebai, et al., Tissue Antigens 22:107 (1983)). Typically two to four passages were required for effective depletion. Subsequently, the anti HLA(A,B,C) antibody W6/32 (Barnstable, et al., Cell 14:9 (1978)) was used to capture HLA-A molecules. Protein purity, concentration, and effectiveness of depletion steps were monitored by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).

Binding Assays

[0244] Quantitative assays for the binding of peptides to soluble class I molecules on the basis of the inhibition of binding of a radiolabeled standard probe peptide to detergent solubilized HLA molecules were performed as described in the literature (Kubo, et al., J. Immunol. 152:3913 (1994); Kast, et al., J. Immunol. 152:3904 (1994); Sidney, et al., J. Immunol. 154:247 (1995); Sette, et al., Mol. Immunol. 31:813 (1994); Ruppert, et al., Cell 74:929 (1993)). Briefly, 1-10 nM of radiolabeled probe peptide, iodinated by the Chloramine-T method (Greenwood, et al., Biochem. J. 89:114 (1963)), was co-incubated at room temperature with various amounts of HLA in the presence of 1 .mu.M human .beta..sub.2-microglobulin (Scripps Laboratories, San Diego, Calif., USA) and a cocktail of protease inhibitors. At the end of a two day incubation period, the percent of HLA-bound radioactivity was determined by size exclusion gel filtration chromatography on a TSK 2000 column.

[0245] The A3CON1 peptide (sequence KVFPYALINK; SEQ ID NO:2576) (Kubo, et al., J. Immunol. 152:3913 (1994)) was used as the radiolabeled probe for the A3, A11, A31, and A*6801 assays. A T7Y analogue of HBVc .sub.141-151 (sequence STLPETYVVRR; SEQ ID NO:2577) (Missale, et al., J. Exp. Med. 177:751 (1993)) was used as the radiolabeled probe for the A*3301 assay. In the case of competitive assays, the concentration of peptide yielding 50% inhibition of the binding of the radiolabeled probe peptide (IC.sub.50) was calculated. Peptides were usually tested at one or two high doses, and the IC.sub.50 of peptides yielding positive inhibition were determined in subsequent experiments, in which two to six further dilutions were tested, as necessary. To achieve a suitable signal, HLA concentrations yielding approximately 15% binding of the radiolabeled probe peptide were used for all competitive inhibition assays. Under these conditions the concentration of the labeled peptide is less than the concentration of the HLA molecule and the IC.sub.50 is less than the concentration of the HLA molecule, therefore the measured IC.sub.50s are reasonable approximations of the true K.sub.D values. Each competitor peptide was tested in two to four completely independent experiments. As a positive control, in each experiment, the unlabeled version of the relevant radiolabeled probe was tested and its IC.sub.50 measured. The average IC.sub.50 of A3CON1 for the A3, A11, A31, and A*6801 assays were 11, 6, 18, and 8 nM, respectively. The average IC.sub.50 of the HBVc 141-151 peptide in the A*3301 assay was 29 nM.

Example 2

Implementation of the Extended Supermotif to Improve the Binding Capacity of Native Peptides by Creating Analogs

[0246] HLA motifs and supermotifs (comprising primary and/or secondary residues) are useful in preparing highly cross-reactive native peptides, as demonstrated herein. Moreover, the definition of HLA motifs and supermotifs also allows one to engineer highly cross-reactive epitopes by identifying residues within a native peptide sequence which can be analoged, or "fixed", to confer upon a peptide certain characteristics, e.g., greater cross-reactivity within the group of HLA molecules that make-up the supertype, and/or greater binding affinity for some or all of those HLA molecules Examples of analog peptides that exhibit modulated binding affinity are provided.

[0247] Analogs representing primary anchor single amino acid residues substituted with I residues at the C-terminus of two different B7-like peptides (HBV env 313 and HBV pol 541) were synthesized and tested for their B7-supertype binding capacity. It was found that the I substitution had an overall positive effect on binding affinity and/or cross-reactivity in both cases. In the case of HBV env 313 the 19 (I at C-terminal position 9) replacement was effective in increasing cross-reactivity from 4 to 5 alleles bound by virtue of an almost 400-fold increase B*5401 binding affinity. In the case of HBV pol 541, increased cross-reactivity was similarly achieved by a substantial increase in B*5401 binding. Also, significant gains in binding affinity for B*0702, B51, and B*5301 were observed with the HBV pol 541 I9 analog.

[0248] Moreover, HLA supermotifs are of value in engineering highly cross-reactive peptides by identifying particular residues at secondary anchor positions that are associated with such cross-reactive properties. Demonstrating this, the capacity of a second set of peptides representing discreet single amino acid substitutions at positions one and three of five different B7-supertype binding peptides were synthesized and tested for their B-7 supertype binding capacity. In 4/4 cases the effect of replacing the native residue at position 1 with the aromatic residue F (an "F1" substitution) resulted in an increase in cross-reactivity, compared to the parent peptide, and, in most instances, binding affinity was increased three-fold or better (Table XXII). More specifically, for HBV env 313, MAGE2 170, and HCV core 168 complete supertype cross-reactivity was achieved with the F1 substitution analogs. These gains were achieved by dramatically increasing B*5401 binding affinity. Also, gains in affinity were noted for other alleles in the cases of HCV core 168 (B*3501 and B*5301) and MAGE2 170 (B*3501, B51 and B*5301). Finally, in the case of MAGE3 196, the F1 replacement was effective in increasing cross-reactivity because of gains in B*0702 binding. An almost 70-fold increase in B51 binding capacity was also noted.

[0249] Two analogs were also made using the supermotif positive F substitution at position three (an "F3" substitution). In both instances increases in binding affinity and cross-reactivity were achieved. Specifically, in the case of HBV pol 541, the F3 substitution was effective in increasing cross-reactivity by virtue of its effect on B*5401 binding. In the case of MAGE3 196, complete supertype cross-reactivity was achieved by increasing B*0702 and B*3501 binding capacity. Also, in the case of MAGE3 196, it is notable that increases in binding capacity between 40- and 5000-fold were obtained for B*3501, B51, B*5301, and B*5401.

[0250] In conclusion, these data demonstrate that by the use of even single amino acid substitutions, it is possible to increase the binding affinity and/or cross-reactivity of peptide ligands for HLA supertype molecules.

Example 3

Induction of HLA-Restricted CTL by Subcutaneous Priming With HBV Peptide in Incomplete Freund's Adjuvant (IFA)

[0251] The immunogenicity of HLA class I binding peptides can be assessed in vivo as described in, e.g., Sette et al. J. Immunol. 153:5586-5592 (1994). This example illustrates such a procedure, whereby subcutaneous injection of HBV peptide in Incomplete Freund's Adjuvant (IFA) can be used to induce HBV-specific CTL in mice that are transgenic for a human HLA allele such as the human HLA-A11 allele.

[0252] Priming and In Vitro Restimulation: Mice that are transgenic for HLA-A11, (e.g. HLA-A11/K.sup.b strain) are injected with 100 microliters of an emulsion of purified HBV peptide in IFA. The purified peptide comprises an A11 motif, and is selected from the preferred peptides listed in Table XVI or, alternatively, may be an analog peptide. The peptide epitope (50 .mu.g/mouse) and equimolar amounts of the helper epitope HBV core 128-140 (140 .mu.g/mouse) are dissolved in PBS/5% DMSO, emulsified in WA, and injected subcutaneously at the base of the tail of the transgenic mice. Eleven days after priming, splenocytes (5.times.10.sup.6 cells/well in a 24-well plate) obtained from these animals are restimulated with syngeneic irradiated LPS blasts (2.times.10.sup.6/well) coated with peptide.

[0253] LPS blasts from unprimed HLA-A11 transgenic mice are prepared 72 hours before use by suspending splenocytes in medium containing LPS (25 .mu.g/ml) and dextran sulfate (7 .mu.g/ml). Coating is achieved by incubating 50 .mu.g of peptide with 1.2.times.10.sup.6 LPS blasts in a volume of 0.4 ml of RPMI medium supplemented with 10% FCS for 1 hour at 37.degree. C. The cells are washed once and then co-cultured with splenocytes. After six days, effector cells are assayed, as outlined for example in Example 5, for cytotoxicity against .sup.51Cr-labeled 3A4-721.221-A11/K.sup.b target cells in the presence of the peptide.

[0254] The effector cells (2.times.10.sup.6 cells/well) are re-stimulated at weekly intervals. For the first re-stimulation, peptide-coated LPS blasts are used, followed by peptide-coated A11/K.sup.b cells. Six days after re-stimulation, effector cells are assayed for cytotoxicity as above.

Example 4

Recognition of Generation of Endogenous Processed Antigens After Priming

[0255] This example determines that CTL induced by in vivo priming with peptide (as disclosed in Example 3) recognize endogenously synthesized antigens.

[0256] Effector cells from the procedure disclosed in Example 3 are re-stimulated in vitro using peptide-coated stimulator cells. Six days later, effector cells are assayed for cytotoxicity and the cell lines that contain peptide-specific cytotoxic activity are further re-stimulated. An additional six days later, these cell lines are tested for cytotoxic activity on .sup.51Cr labeled 3A4-721.221-A11/K.sup.b target cells, in the absence or presence of peptide, and also tested on .sup.51Cr labeled target cells bearing the endogenously synthesized antigen.

[0257] The result will demonstrate that CTL lines obtained from animals primed with peptide epitope recognize endogenously synthesized HBV antigen.

Example 5

Activity of CTL-HTL Conjugated Epitopes in Transgenic Mice

[0258] This example illustrates the induction of CTLs in transgenic mice by use of an HBV CTL/HTL peptide conjugate. An analogous study may be found in Oseroff et al. Vaccine 16:823-833 (1998). The peptide composition can comprise multiple CTL and/or HTL epitopes. Such a peptide composition can comprise a lipidated HTL epitope conjugated to a preferred CTL epitope containing, for example, an A11 motif or an analog of that epitope.

[0259] Lipopeptides are prepared by coupling the appropriate fatty acid to the amino terminus of the resin bound peptide. A typical procedure is as follows: A dichloromethane solution of a four-fold excess of a pre-formed symmetrical anhydride of the appropriate fatty acid is added to the resin and the mixture is allowed to react for two hours. The resin is washed with dichloromethane and dried. The resin is then treated with trifluoroacetic acid in the presence of appropriate scavengers [e.g. 5% (v/v) water] for 60 minutes at 20.degree. C. After evaporation of excess trifluoroacetic acid, the crude peptide is washed with diethyl ether, dissolved in methanol and precipitated by the addition of water. The peptide is collected by filtration and dried.

[0260] Preparation of Peptides for Immunization: Peptide Compositions are Typically resuspended in DMSO at a concentration of 20 mg/ml. Before use, peptides are prepared at the required concentration by dilution in saline or the appropriate medium.

[0261] Immunization procedures: A11/K.sup.b mice, which are transgenic for the human HLA A11 allele, are primed subcutaneously (base of the tail) with 0.1 ml of peptide conjugate formulated in saline, or DMSO/saline. Seven days after priming, splenocytes obtained from these animals are restimulated with syngeneic irradiated LPS-activated lymphoblasts coated with peptide.

[0262] Media:

[0263] a. RPMI-1640 supplemented with 10% fetal calf serum (FCS) 2 mM Glutamine, 50 .mu.g/ml Gentamicin and 5.times.10.sup.-5 M 2-mercaptoethanol serves as culture medium

[0264] b. RPMI-1640 containing 25 mM HEPES buffer and supplemented with 2% (FCS) is used as cell washing medium.

[0265] Cell lines: The 3A4-721.221-A11/K.sup.b cell line is used as target cells. This cell line is an EBV transformed cell line that was mutagenized and selected to be Class I negative which was transfected with an HLA-A11/K.sup.b gene.

[0266] LPS-activated lymphoblasts: Splenocytes obtained from transgenic mice are resuspended at a concentration of 1-1.5.times.10.sup.6/m1 in culture medium supplemented with 25 .mu.g/ml LPS and 7 .mu.g/ml dextran sulfate in 75 cm.sup.2 tissue culture flasks. After 72 hours at 37.degree. C., the lymphoblasts are collected for use by centrifugation.

[0267] Peptide coating of lymphoblasts: Peptide coating of the LPS activated lymphoblasts is achieved by incubating 30.times.10.sup.6 irradiated (3000 rads) lymphoblasts with 100 .mu.g of peptide in 1 ml of R10 medium for 1 hr at 37.degree. C. Cells are then washed once and resuspended in culture medium at the desired concentration.

[0268] In vitro CTL activation: One week after priming, spleen cells (30.times.10.sup.6 cells/flask) are co-cultured at 37.degree. C. with syngeneic, irradiated (3000 rads), peptide coated lymphoblasts (10.times.10.sup.6 cells/flask) in 10 ml of culture medium/T25 flask. After six days, the effector cells are harvested and assayed for cytotoxic activity.

[0269] Assay for cytotoxic activity: Target cells (1.0-1.5.times.10.sup.6) are incubated at 37.degree. C. in the presence of 200 .mu.l of sodium .sup.51Cr chromate. After 60 minutes, cells are washed three times and resuspended in R10 medium. Peptide is added where required at a concentration of 1 .mu.g/ml. For the assay, 104 .sup.51Cr-labeled target cells are added to different concentrations of effector cells (final volume of 200 .mu.l) in U-bottom 96-well plates. After a 6 hour incubation period at 37.degree. C., a 0.1 ml aliquot of supernatant is removed from each well and radioactivity is determined in a Micromedic automatic gamma counter. The percent specific lysis is determined by the formula: percent specific release=100.times.(experimental release-spontaneous release)/(maximum release-spontaneous release). To facilitate comparison between separate CTL assays run under the same conditions, % .sup.51Cr release data is expressed as lytic units/10.sup.6 cells. One lytic unit is arbitrarily defined as the number of effector cells required to achieve 30% lysis of 10,000 target cells in a 6 hour .sup.51Cr release assay. To obtain specific lytic units/10.sup.6, the lytic units/10.sup.6 obtained in the absence of peptide is subtracted from the lytic units/10.sup.6 obtained in the presence of peptide. For example, if 30% .sup.51Cr release is obtained at the E:T of 50:1 (i.e., 5.times.10.sup.5 effector cells for 10,000 targets) in the absence of peptide and 5:1 (i.e., 5.times.10.sup.4 effector cells for 10,000 targets) in the presence of peptide, the specific lytic units would be: (1.times.10.sup.6(5.times.10.sup.4)-(1.times.10.sup.6(5.times.10.sup.5)=1- 8 LU/10.sup.6.

[0270] The results are analyzed to assess the magnitude of the CTL responses of animals injected with the immunogenic CTL/HTL conjugate vaccine preparation. Analyses similar to this may be performed to evaluate the immunogenicity of peptide conjugates containing multiple CTL epitopes and/or multiple HTL epitopes. In accordance with these procedures it is found that CTL and HTL responses are induced.

Example 7

Induction of Specific CTL Response in Humans

[0271] A human clinical trial for an immunogenic composition comprising CTL and HTL epitopes is set up as an IND Phase I, dose escalation study (5, 50 and 500 .mu.g) and carried out as a randomized, double-blind, placebo-controlled trial. Such a trial is designed, for example, as follows:

[0272] A total of about 27 subjects are enrolled and divided into 3 groups:

[0273] Group I: 3 subjects are injected with placebo and 6 subjects are injected with 5 .mu.g of peptide composition;

[0274] Group II: 3 subjects are injected with placebo and 6 subjects are injected with 50 .mu.g peptide composition;

[0275] Group III: 3 subjects are injected with placebo and 6 subjects are injected with 500 .mu.g of peptide composition.

[0276] After 4 weeks following the first injection, all subjects receive a booster inoculation at the same dosage.

[0277] The endpoints measured in this study relate to the safety and tolerability of the peptide composition as well as its immunogenicity. Cellular immune responses to the peptide composition are an index of the intrinsic activity of this the peptide composition, and can therefore be viewed as a measure of biological efficacy. The following summarize the clinical and laboratory data that relate to safety and efficacy endpoints.

[0278] Safety: The incidence of adverse events is monitored in the placebo and drug treatment group and assessed in terms of degree and reversibility.

[0279] Evaluation of Vaccine Efficacy: For evaluation of vaccine efficacy, subjects are bled before and after injection. Peripheral blood mononuclear cells are isolated from fresh heparinized blood by Ficoll-Hypaque density gradient centrifugation, aliquoted in freezing media and stored frozen. Samples are assayed for CTL and HTL activity.

[0280] Thus, the vaccine is found to be both safe and efficacious.

Example 8

Phase II Trials in Patients Infected with HBV

[0281] Phase II trials are performed to study the effect of administering the CTL-HTL peptide compositions to patients (male and female) having chronic HBV infection. A main objective of the trials is to determine an effective dose and regimen for inducing CTLs in chronically infected HBV patients, to establish the safety of inducing a CTL response in these patients, and to see to what extent activation of CTLs improves the clinical picture of chronically infected CTL patients, as manifested by a transient flare in alanine aminotransferase (ALT), normalization of ALT, and reduction in HBV DNA. Such a study is designed, for example, as follows:

[0282] The studies are performed in multiple centers in the U.S. and Canada. The trial design is an open-label, uncontrolled, dose escalation protocol wherein the peptide composition is administered as a single dose followed six weeks later by a single booster shot of the same dose. The dosages are 50, 500 and 5,000 micrograms per injection. Drug-associated adverse effects are recorded.

[0283] There are three patient groupings. The first group is injected with 50 micrograms of the peptide composition and the second and third groups with 500 and 5,000 micrograms of peptide composition, respectively. The patients within each group range in age from 21-65 and include both males and females. The patients represent diverse ethnic backgrounds. All of them are infected with HBV for over five years and are HIV, HCV and HDV negative, but have positive levels of HBe antigen and HBs antigen.

[0284] The magnitude and incidence of ALT flares and the levels of HBV DNA in the blood are monitored to assess the effects of administering the peptide compositions. The levels of HBV DNA in the blood are an indirect indication of the progress of treatment. The vaccine composition is found to be both safe and efficacious in the treatment of chronic HBV infection.

Example 9

Selection of CTL and HTL Epitopes for Inclusion in an HBV-Specific Vaccine

[0285] This example illustrates the procedure for the selection of peptide epitopes for vaccine compositions of the invention.

[0286] The following principles are utilized when selecting an array of epitopes for inclusion in a polyepitopic composition, or for selecting epitopes to be included in a vaccine composition and/or to be encoded by a minigene. Each of the following principles are balanced in order to make the selection.

[0287] 1.) Epitopes are selected which, upon administration, mimic immune responses that have been observed to be correlated with HBV clearance. For HLA Class I this includes 3-4 epitopes that come from at least one antigen of HBV. In other words, it has been observed that in patients who spontaneously clear HBV, that they had generated an immune response to at least 3 epitopes on at least one HBV antigen. For HLA Class II a similar rationale is employed; again 3-4 epitopes are selected from at least one HBV antigen.

[0288] 2.) Epitopes are selected that have the requisite binding affinity established to be correlated with immunogenicity: for HLA Class I an IC.sub.50 of 500 nM or less, or for Class II an IC.sub.50 of 1000 nM or less.

[0289] 3.) Sufficient supermotif bearing peptides, or a sufficient array of allele-specific motif bearing peptides, are selected to give broad population coverage. For example, epitopes are selected to provide at least 80% population coverage. A Monte Carlo analysis, a statistical evaluation known in the art, is employed to assess population coverage.

[0290] 4.) When selecting epitopes for HBV antigens it is often preferable to select native epitopes. Therefore, of particular relevance for infectious disease vaccines, are epitopes referred to as "nested epitopes." Nested epitopes occur where at least two epitopes overlap in a given peptide sequence. A peptide comprising "transcendent nested epitopes" is a peptide that has both HLA class I and HLA class II epitopes in it.

[0291] When providing nested epitopes, a sequence that has the greatest number of epitopes per provided sequence is provided. A limitation on this principle is to avoid providing a peptide that is any longer than the amino terminus of the amino terminal epitope and the carboxyl terminus of the carboxyl terminal epitope in the peptide. When providing a longer peptide sequence, such as a sequence comprising nested epitopes, the sequence is screened in order to insure that it does not have pathological or other deleterious biological properties.

[0292] 5.) When creating a minigene, as disclosed in greater detail in the Example 10, an objective is to generate the smallest peptide possible that encompasses the epitopes of interest. The principles employed are similar, if not the same as those employed when selecting a peptide comprising nested epitopes. Thus, upon determination of the nucleic acid sequence to be provided as a minigene, the peptide encoded thereby is analyzed to determine whether any "junctional epitopes" have been created. A junctional epitope is an actual binding epitope, as predicted, e.g., by motif analysis. Junctional epitopes are to be avoided because the recipient may generate an immune response to that epitope. Of particular concern is a junctional epitope that is a "dominant epitope." A dominant epitope may lead to such a zealous response that immune responses to other epitopes are diminished or suppressed.

[0293] Peptide epitopes for inclusion in vaccine compositions are, for example, selected from those listed in Table XXIII. A vaccine composition comprised of selected peptides, when administered, is safe, efficacious, and elicits an immune response similar in magnitude of an immune response that clears an acute HBV infection.

Example 10

Construction of Minigene Multi-Epitope DNA Plasmids

[0294] Expression plasmids have been constructed and evaluated as described, for example, in U.S. Ser. No. 60/085,751 filed May 15, 1998 and U.S. Ser. No. 09/078,904 filed May 13, 1998. The binding peptide epitopes and their positions for some of the plasmids described therein are shown in FIG. 1 as example of the orientation of peptide epitopes in minigene constructs. Such a plasmid may, for example, also include multiple CTL and HTL peptide epitopes. In the present example, HLA-A11 motif-bearing peptides are used in conjunction with DR supermotif-bearing peptides. Preferred A11 epitopes are identified, for example, in Table XVI or Table XXI and peptide epitopes recognized by HLA DR molecules (Tables XVIII and XIX). Four class I A11 motif-bearing peptide epitopes or analogs of those peptide epitopes derived from the same HBV antigen, e.g. the envelope protein, are selected as CTL epitopes. Four class II motif-bearing peptide epitopes derived from the same antigen, e.g., the envelope protein, are selected as HTL epitopes. These epitopes are then incorporated into a minigene for expression in an expression vector.

[0295] This example illustrates the methods to be used for construction of such a minigene-bearing expression plasmid. Other expression vectors that may be used for minigene compositions are available and known to those of skill in the art.

[0296] A pMin minigene DNA plasmid is constructed from an early generation DNA plasmid designated as pMin.0. This plasmid contains a consensus Kozak sequence and a consensus murine kappa Ig-light chain signal sequence followed by a string of CTL and HTL epitopes selected in accordance with principles disclosed herein. The pMIN sequence encodes an open reading frame fused to the Myc and His antibody epitope tag coded for by the pcDNA 3.1 Myc-His vector.

[0297] Overlapping oligonucleotides, for example eight oligonucleotides, averaging approximately 70 nucleotides in length with 15 nucleotide overlaps, are synthesized and HPLC-purified. The oligonucleotides encode the selected peptide epitopes as well as appropriate linker nucleotides. The final multiepitope minigene is assembled by extending the overlapping oligonucleotides in three sets of reactions using PCR. A Perkin/Elmer 9600 PCR machine is used and a total of 30 cycles are performed using the following conditions: 95.degree. C. for 15 sec, annealing temperature (5.degree. below the lowest calculated Tm of each primer pair) for 30 sec, and 72.degree. C. for 1 min.

[0298] For the first PCR reaction, 5 .mu.g of each of two oligonucleotides are annealed and extended: Oligonucleotides 1+2, 3+4, 5+6, and 7+8 are combined in 100 .mu.l reactions containing Pfu polymerase buffer (1.times.=10 mM KCL, 10 mM (NH.sub.4).sub.2SO.sub.4, 20 mM Tris-chloride, pH 8.75, 2 mM MgSO.sub.4, 0.1% Triton X-100, 100 .mu.g/ml BSA), 0.25 mM each dNTP, and 2.5 U of Pfu polymerase. The full-length dimer products are gel-purified, and two reactions containing the product of 1+2 and 3+4, and the product of 5+6 and 7+8 are mixed, annealed, and extended for 10 cycles. Half of the two reactions are then mixed, and 5 cycles of annealing and extension carried out before flanking primers are added to amplify the full length product for 25 additional cycles. The full-length product is gel-purified and cloned into pCR-blunt (Invitrogen) and individual clones are screened by sequencing.

Example 11

The Plasmid Construct and the Degree to which it Induces Immunogenicity

[0299] The degree to which the plasmid construct prepared using the methodology outlined in Example 10 is able to induce immunogenicity is evaluated through in vivo injections into mice and in vitro CTL culture and cytotoxicity assays as detailed e.g., in U.S. Ser. No. 60/085,751 filed May 15, 1998. To assess the capacity of the pMin minigene construct to induce CTLs in vivo, HLA-A11/K.sup.b transgenic mice are immunized intramuscularly with 100 .mu.g of naked cDNA. As a means of comparing the level of CTLs induced by cDNA immunization, a control group of animals is also immunized with an actual peptide composition that comprises multiple epitopes synthesized as a single polypeptide.

[0300] Splenocytes from immunized animals are stimulated twice with each of the peptide epitopes encoded in the minigene, then assayed for peptide-specific cytotoxic activity in a .sup.51Cr release assay. The results indicate the magnitude of the CTL response directed against each of its A11-restricted epitopes, thus indicating the in vivo immunogenicity of the minigene vaccine. It is, therefore, found that the minigene elicits immune responses directed toward A11-restricted epitopes.

Example 12

Peptide Composition for Prophylactic Uses

[0301] Vaccine compositions of the present invention are used to prevent HBV infection in persons who are at risk. For example, a polyepitopic peptide epitope composition containing multiple CTL and HTL epitopes such as those selected in Examples 9 and/or 10, which are also selected to target greater than 80% of the population, is administered to individuals at risk for HBV infection. The composition is provided as a single lipidated polypeptide that encompasses multiple epitopes. The vaccine is administered in an aqueous carrier comprised of Freunds Incomplete Adjuvant. The dose of peptide for the initial immunization is from about 1 to about 5,000 .mu.g for a 70 kg patient. The initial administration of vaccine is followed by booster dosages at 4 weeks followed by evaluation of the magnitude of the immune response in the patient by techniques that determine the presence of epitope-specific CTL populations in a PBMC sample. Additional booster doses are administered as required. The composition is found to be both safe and efficacious as a prophylaxis against HBV infection.

[0302] Alternatively, the polyepitopic peptide composition can be administered as a nucleic acid in accordance with methodologies known in the art and disclosed herein.

Example 13

Polyepitopic Vaccine Compositions Derived from Native HBV Sequences

[0303] A native HBV polyprotein sequence is screened, preferably using computer algorithms defined for each class I and/or class II supermotif or motif, to identify "relatively short" regions of the polyprotein that comprise multiple epitopes. This relatively short sequence that contains multiple distinct, even overlapping, epitopes is selected and used to generate a minigene construct. The construct is engineered to express the peptide, which corresponds to the native protein sequence. The "relatively short" peptide is less than 100 amino acids in length, preferably less than 75 amino acids in length, and more preferably less than 50 amino acids in length. The protein sequence of the vaccine composition is selected because it has maximal number of epitopes contained within the sequence. As noted herein, epitope motifs may be overlapping (i.e., frame shifted relative to one another) with frame shifted overlapping epitopes, e.g. two 9-mer epitopes can be present in a 10 amino acid peptide. Such a vaccine composition is administered for therapeutic or prophylactic purposes.

[0304] The vaccine composition will preferably include, for example, three CTL epitopes and at least one HTL epitope from the source antigen. Junctional sequences will be analyzed to avoid sequences containing a potentially immunodominant epitope. This polyepitopic native sequence is administered either as a peptide or as a nucleic acid sequence which encodes the peptide. Alternatively, an analog can be made of this native sequence.

[0305] The embodiment of this example provides for the possibility that an as yet undiscovered aspect of immune system processing will apply to the native nested sequence and thereby facilitate the production of therapeutic or prophylactic immune response-inducing vaccine compositions. Additionally such an embodiment provides for the possibility of motif-bearing epitopes for an HLA makeup that is presently unknown. Furthermore, this embodiment directs the immune response to sequences that are present in native HBV antigens. Lastly, the embodiment provides an economy of scale when producing nucleic acid vaccine compositions.

[0306] Related to this embodiment, computer programs can be derived which identify, in a target sequence, the greatest number of epitopes per sequence length.

Example 14

Polyepitopic Vaccine Compositions Directed to Multiple Diseases

[0307] The HBV peptide epitopes of the present invention are used in conjunction with peptide epitopes from target antigens related to one or more other diseases, to create a vaccine composition that is useful for the prevention or treatment of HBV as well as another disease. Examples of other diseases include, but are not limited to, HIV, HCV, and HPV.

[0308] For example, a polyepitopic peptide composition comprising multiple CTL and HTL epitopes that target greater than 98% of the population may be created for administration to individuals at risk for both HBV and HIV infection. The composition can be provided as a single polypeptide that incorporates the multiple epitopes from the various disease-associated sources.

Example 15

Use of Peptides to Evaluate an Immune Response

[0309] Peptides of the invention may be used to analyze an immune response for the presence of specific CTL populations corresponding to HBV. Such an analysis may be performed as described by Ogg et al., Science 279:2103-2106, 1998. In the following example, peptides in accordance with the invention are used as a reagent for diagnostic or prognostic purposes, not as an immunogen.

[0310] In this example highly sensitive human leukocyte antigen tetrameric complexes ("tetramers") may be used for a cross-sectional analysis of, for example, HBV Env-specific CTL frequencies from untreated HLA A*0201-positive individuals at different stages of infection using an HBV Env peptide containing an A2.1 extended motif. Tetrameric complexes are synthesized as described (Musey et al., N. Engl. J. Med. 337:1267, 1997). Briefly, purified HLA heavy chain (A2.1 in this example) and .beta.2-microglobulin are synthesized by means of a prokaryotic expression system. The heavy chain is modified by deletion of the transmembrane-cytosolic tail and COOH-terminal addition of a sequence containing a BirA enzymatic biotinylation site. The heavy chain, .beta.2-microglobulin, and peptide are refolded by dilution. The 45-kD refolded product isolated by fast protein liquid chromatography and then biotinylated by BirA in the presence of biotin (Sigma, St. Louis, Mo.), adenosine 5' triphosphate and magnesium. Streptavidin-phycoerythrin conjugate is added in a 1:4 molar ratio, and the tetrameric product is concentrated to 1 mg/ml. The resulting product is referred to as tetramer-phycoerythrin.

[0311] Approximately one million PBMCs are centrifuged at 300 g for 5 minutes and resuspended in 50 ul of cold phosphate-buffered saline. Tri-color analysis is performed with the tetramer-phycoerythrin, along with anti-CD8-Tricolor, and anti-CD38. The PBMCs are incubated with tetramer and antibodies on ice for 30 to 60 min and then washed twice before formaldehyde fixation. Gates are applied to contain >99.98% of control samples. Controls for the tetramers include both A*0201-negative individuals and A*0201-positive uninfected donors. The percentage of cells stained with the tetramer is then determined by flow cytometry. The results indicate the number of cells in the PBMC sample that contain epitope-restricted CTLs, thereby readily indicating the stage of infection with HBV or the status of exposure to HBV or to a vaccine that elicits a protective response.

Example 16

Use of Peptide Epitopes to Evaluate Recall Responses

[0312] The peptide epitopes of the invention are used as reagents to evaluate T cell responses such as acute or recall responses, in patients. Such an analysis may be performed on patients who have recovered from infection or who are chronically infected with HBV or who have been vaccinated with an HBV vaccine.

[0313] For example, the class I restricted CTL response of persons at risk for HBV infection who have been vaccinated may be analyzed. The vaccine may be any BBV vaccine. PBMC are collected from vaccinated individuals and HLA typed. Appropriate peptide reagents that, are highly conserved and, optimally, bear supermotifs to provide cross-reactivity with multiple HLA supertype family members are then used for analysis of samples derived from individuals who bear that HLA type.

[0314] PBMC from vaccinated individuals are separated on Ficoll-Histopaque density gradients (Sigma Chemical Co., St. Louis, Mo.), washed three times in HBSS (GIBCO Laboratories), resuspended in RPMI-1640 (GIBCO Laboratories) supplemented with L-glutamine (2 mM), penicillin (50 U/ml), streptomycin (50 .mu.g/m1), and Hepes (10 mM) containing 10% heat-inactivated human AB serum (complete RPMI) and plated using microculture formats. Synthetic peptide is added at 10 .mu.g/ml to each well and recombinant HBc Ag is added at 1 .mu.g/ml to each well as a source of T cell help during the first week of stimulation.

[0315] In the microculture format, 4.times.10.sup.5 PBMC are stimulated with peptide in 8 replicate cultures in 96-well round bottom plate in 1000/well of complete RPMI. On days 3 and 10, 100 ml of complete RPMI and 20 U/ml final concentration of rIL-2 are added to each well. On day 7 the cultures are transferred into a 96-well flat-bottom plate and restimualted with peptide, rIL-2 and 10.sup.5 irradiated (3,000 rad) autologous feeder cells. The cultures are tested for cytotoxic activity on day 14. A positive CTL response requires two or more of the eight replicate cultures to display greater than 10% specific .sup.51Cr release, based on comparison with uninfected control subjects as previously described (Rehermann, et al., Nature Med. 2:1104, 1108, 1996; Rehermann et al., J. Clin. Invest. 97:1655-1665, 1996; and Rehermann et al. J. Clin. Invest. 98:1432-1440, 1996).

[0316] Target cell lines are autologous and allogeneic EBV-transformed B-LCL that are either purchased from the American Society for Histocompatibility and Immunogenetics (ASHI, Boston, Mass.) or established from the pool of patients as described (Guilhot, et al. J. Virol. 66:2670-2678, 1992).

[0317] Cytotoxicity assays are performed in the following manner. Target cells consist of either allogeneic HLA-matched or autologous EBV-transformed B lymphoblastoid cell line that are incubated overnight with synthetic peptide at 10<M and labeled with 100<Ci of .sup.51Cr (Amersham Corp., Arlington Heights, Ill.) for 1 hour after which they are washed four times with HBSS. Cytolytic activity is determined in a standard 4-h, split well .sup.51Cr release assay using U-bottomed 96 well plates containing 3,000 targets/well. Stimulated PBMC are tested at E/T ratios of 20-50:1 on day 14. Percent cytotoxicity is determined from the formula: 100.times.[(experimental release-spontaneous release)/maximum release-spontaneous release)]. Maximum release is determined by lysis of targets by detergent (2% Triton X-100.RTM.; Sigma Chemical Co., St. Louis, Mo.). Spontaneous release is <25% of maximum release for all experiments. The results of such an analysis will indicate to what extent HLA-restricted CTL populations have been stimulated with the vaccine. Of course, this protocol can also be used to monitor prior HBV exposure.

[0318] The above examples are provided to illustrate the invention but not to limit its scope. For example, the human terminology for the Major Histocompatibility Complex, namely HLA, is used throughout this document. It is to be appreciated that these principles can be extended to other species as well. Moreover, peptide epitopes have been disclosed in the related application U.S. Ser. No. 08/820,360, which was previously incorporated by reference. Thus, other variants of the invention will be readily apparent to one of ordinary skill in the art and are encompassed by the appended claims. All publications, patents, and patent application cited herein are hereby incorporated by reference for all purposes.

TABLE-US-00002 TABLE I POSITION POSTION POSITION 2 (Primary Anchor) 3 (Primary Anchor) C Terminus (Primary Anchor) SUPERMOTIF A1 T, I, L, V, M, S F, W, Y A2 L, I, V, M, A, T, Q I, V, M, A, T, L A3 V, S, M, A, T, L, I R, K A24 Y, F, W, I, V, L, M, T F, I, Y, W, L, M B7 P V, I, L, F, M, W, Y, A B27 R, H, K F, Y, L, W, M, I B44 E, D F, W, Y, L, I, M, V, A B58 A, T, S F, W, Y, L, I, V B62 Q, L, I, V, M, P F, W, Y, M, I, V MOTIF A1 T, S, M Y A1 D, E, A, S Y A2.1 L, M, V, Q, I, A, T V, L, I, M, A, T A3 L, M, V, I, S, A, T, F, C, G, D K, Y, R, H, F, A A11 V, T, M, L, I, S, A, G, N, C, D, F K, R, Y, H A24 Y, F, W, M F, L, I, W A*3101 M, V, T, A, L, I, S R, K A*3301 M, V, A, L, F, I, S, T R, A*6801 A, V, T, M, S, L, I R, B*0702 P L, M, F, W Y, A, I, V B*3501 P L, M, F, W, Y, I, V, A B51 P L, I, V, F, W, Y, A, M B*5301 P I, M, F, W, Y, A, L, V B*5401 P A, T, I, V, L, M, F, W, Y Bold residues are preferred, italicized residues are less preferred. A peptide is considered motif-bearing if it has primary anchors at each primary anchor position for a motif or supermotif as specified in the above table.

TABLE-US-00003 TABLE II POSITION C-terminus SUPERMOTIFS A1 1.degree. Anchor 1.degree. Anchor T, I, L, V, M, S F, W, Y A2 1.degree. Anchor 1.degree. Anchor L, I, V, M, A, T, Q L, I, V, M, A, T A3 preferred 1.degree. Anchor Y, F, W (4/5) Y, F, W (3/5) Y, F, W (4/5) P (4/5) 1.degree.Anchor V, S, M, A, T, R, K L, I deleterious D, E (3/5); P (5/5) D, E (4/5) A24 1.degree. Anchor 1.degree. Anchor Y, F, W, I, V, L, M, T F, I, Y, W, L, M B7 preferred F, W, Y (5/5) 1.degree.Anchor F, W, Y (4/5) F, W, Y 1.degree.Anchor L, I, V, M (3/5) P (3/5) V, I, L, F, M, W, Y, A 1.degree. Anchor 1.degree. Anchor deleterious D, E (3/5); P(5/5); D, E (3/5) G (4/5) Q, N (4/5) D, E G(4/5); A(3/5); Q, N (3/5) (4/5) B27 1.degree. Anchor 1.degree. Anchor R, H, K F, Y, L, W, M, I B44 1.degree. Anchor 1.degree. Anchor E, D F, W, Y, L, I, M, V, A B58 1.degree. Anchor 1.degree. Anchor A, T, S F, W, Y, L, I, V B62 1.degree. Anchor 1.degree. Anchor Q, L, I, V, M, P F, W, Y, M, I, V MOTIFS A1 preferred G, F, Y, W 1.degree.Anchor D, E, A Y, F, W P D, E, Q, N Y, F, W 1.degree.Anchor 9-mer S, T, M Y deleterious D, E R, H, K, L, I, V, A G A M, P A1 preferred G, R, H, K A, S, T, C, L, I, 1.degree.Anchor G, S, T, C A, S, T, C L, I, V, M D, E 1.degree.Anchor 9-mer V, M D, E, A, S Y deleterious A R, H, K, D, E, D, E P, Q, N R, H, K P, G G, P P, Y, F, W POSITION or C-terminus C-terminus A1 preferred Y, F, W 1.degree.Anchor D, E, A, Q, N A Y, F, W, Q, N P, A, S, T, C G, D, E P 1.degree.Anchor 10-mer S, T, M Y deleterious G, P R, H, K, G, L, I, D, E R, H, K Q, N, A R, H, K, Y, F, W R, H, K A V, M A1 preferred Y, F, W S, T, C, L, I, V, M 1.degree.Anchor A Y, F, W P, G G Y, F, W 1.degree.Anchor 10-mer D, E, A, S Y deleterious R, H, K R, H, K, D, E, P G P, R, H, K Q, N P, Y, F, W A2.1 preferred Y, F, W 1.degree.Anchor Y, F, W S, T, C Y, F, W A P 1.degree.Anchor 9-mer L, M, I, V, Q, V, L, I, M, A, T deleterious D, E, P D, E, R, K, H R, K, H D, E, R, K, H A2.1 preferred A, Y, F, W 1.degree.Anchor L, V, I, M G G F, Y, W, 1.degree.Anchor 10-mer L, M, I, V, Q, L, V, I, M V, L, I, M, A, T A, T deleterious D, E, P D, E R, K, H, A P R, K, H D, E, R, R, K, H K, H A3 preferred R, H, K 1.degree.Anchor Y, F, W P, R, H, K, Y, F, W A Y, F, W P 1.degree.Anchor L, M, V, I, S, K, Y, R, H, F, A A, T, F, C, G, D deleterious D, E, P D, E A11 preferred A 1.degree.Anchor Y, F, W Y, F, W A Y, F, W Y, F, W P 1.degree.Anchor V, T, L, M, I, K, R, Y, H S, A, G, N, C, D, F deleterious D, E, P A G A24 preferred Y, F, W, R, H, K 1.degree.Anchor S, T, C Y, F, W Y, F, W 1.degree.Anchor 9-mer Y, F, W, M F, L, I, W deleterious D, E, G D, E G Q, N, P D, E, R, H, K G A, Q, N A24 preferred 1.degree.Anchor P Y, F, W, P P 1.degree.Anchor 10-mer Y, F, W, M F, L, I, W deleterious G, D, E Q, N R, H, K D, E A Q, N D, E, A A3101 preferred R, H, K 1.degree.Anchor Y, F, W P Y, F, W Y, F, W A, P 1.degree.Anchor M, V, T, A, L, R, K I, S deleterious D, E, P D, E A, D, E D, E D, E D, E A3301 preferred 1.degree.Anchor Y, F, W A, Y, F, W 1.degree.Anchor M, V, A, L, F, R, K I, S, T deleterious G, P D, E A6801 preferred Y, F, W, S, T, C 1.degree.Anchor Y, F, W, L, I, Y, F, W P 1.degree.Anchor A, V, T, M, S, V, M R, K L, I deleterious G, P D, E, G R, H, K A B0702 preferred R, H, K, F, W, Y 1.degree.Anchor R, H, K R, H, K R, H, K R, H, K P, A 1.degree.Anchor P L, M, F, W, Y, A, I, V deleterious D, E, Q, N, P D, E, P D, E D, E G, D, E Q, N D, E B3501 preferred F, W, Y, L, I, V, 1.degree.Anchor F, W, Y F, W, Y 1.degree.Anchor M P L, M, F, W, Y, I, V, A deleterious A, G, P G G B51 preferred L, I, V, M, F, W, 1.degree.Anchor F, W, Y S, T, C F, W, Y G F, W, Y 1.degree.Anchor Y P L, I, V, F, W, Y, A, M deleterious A, G, P, D, E, R, D, E G D, E, Q, N G, D, E H, K, S, T, C B5301 preferred L, I, V, M, F, W, 1.degree.Anchor F, W, Y S, T, C F, W, Y L, I, V, M, F, F, W, Y 1.degree.Anchor Y P W, Y I, M, F, W, Y, A, L, V deleterious A, G, P, Q, N G R, H, K, Q, N D, E B5401 preferred F, W, Y 1.degree.Anchor F, W, Y, L, I, L, I, V, M A, L, I, V, M F, W, Y, A, P 1.degree.Anchor P V, M A, T, I, V, L, M, F, W, Y deleterious G, P, Q, N, D, E G, D, E, S, T, C R, H, K, D, E D, E Q, N, D, G, E D, E Italicized residues indicate less preferred or "tolerated" residues. The information in Table II is specific for 9-mers unless otherwise specified.

TABLE-US-00004 TABLE III SEQ ID POSITION NO: MOTIFS DR4 preferred F, M, Y, L, I, M T I V, S, T, C, P, A, M, H M, H V, W L, I, M deleterious W R W, D, E DR1 preferred M, F, L, I, V, P, A, M, Q V, M, A, T, S, P, M A, V, M W, Y L, I, C, deleterious C C, H F, D C, W, D G, D, E D 2578 DR7 preferred M, F, L, I, V, M W A, I, V, M, S, A, C, M I, V W, Y T, P, L, 2579 deleterious C G, G, R, D N G DR Supermotif M, F, L, I, V, V, M, S, T, A, C, W, Y P, L, I DR3 MOTIFS motif a L, I, V, M, F, Y D preferred motif b L, I, V, M, F, D, N, Q, E, K, R, H preferred A, Y S, T Italicized residues indicate less preferred or "tolerated" residues.

TABLE-US-00005 TABLE IV HLA Class I Standard Peptide Binding Affinity. STANDARD SEQ STANDARD BINDING ID ALLELE PEPTIDE SEQUENCE AFFINITY (nM) NO: A*0101 944.02 YLEPAIAKY 25 2486 A*0201 941.01 FLPSDYFPSV 5.0 2487 A*0202 941.01 FLPSDYFPSV 4.3 2487 A*0203 941.01 FLPSDYFPSV 10 2487 A*0206 941.01 FLPSDYFPSV 3.7 2487 A*0207 941.01 FLPSDYFPSV 23 2487 A*6802 1072.34 YVIKVSARV 40 2488 A*0301 941.12 KVFPYALINK 11 2489 A*1101 940.06 AVDLYHFLK 6.0 2490 A*3101 941.12 KVFPYALINK 18 2489 A*3301 1083.02 STLPETYVVRR 29 2491 A*6801 941.12 KVFPYALINK 8.0 2489 A*2401 979.02 AYIDNYNKF 12 2492 B*0702 1075.23 APRTLVYLL 5.5 2493 B*3501 1021.05 FPFKYAAAF 7.2 2494 B51 1021.05 FPFKYAAAF 5.5 2494 B*5301 1021.05 FPFKYAAAF 9.3 2494 B*5401 1021.05 FPFKYAAAF 10 2494

TABLE-US-00006 TABLE V HLA Class II Standard Peptide Binding Affinity. Binding Standard Affinity SEQ ID Allele Nomenclature Peptide Sequence (nM) NO: DRB1*0101 DR1 515.01 PKYVKQNTLKLAT 5.0 2495 DRB1*0301 DR3 829.02 YKTIAFDEEARR 300 2496 DRB1*0401 DR4w4 515.01 PKYVKQNTLKLAT 45 2495 DRB1*0404 DR4w14 717.01 YARFQSQTTLKQKT 50 2497 DRB1*0405 DR4w15 717.01 YARFQSQTTLKQKT 38 2497 DRB1*0701 DR7 553.01 QYIKANSKFIGITE 25 2498 DRB1*0802 DR8w2 553.01 QYIKANSKFIGITE 49 2498 DRB1*0803 DR8w3 553.01 QYIKANSKFIGITE 1600 2498 DRB1*0901 DR9 553.01 QYIKANSKFIGITE 75 2498 DRB1*1101 DRSw11 553.01 QYIKANSKFIGITE 20 2498 DRB1*1201 DR5w12 1200.05 EALIHQLKINPYVLS 298 2499 DRB1*1302 DR6w19 650.22 QYIKANAKFIGITE 3.5 2500 DRB1*1501 DR2w2.beta.1 507.02 GRTQDENPVVHFFK 9.1 2501 NIVTPRTPPP DRB3*0101 DR52a 511 NGQIGNDPNRDIL 470 2502 DRB4*0101 DRw53 717.01 YARFQSQTTLKQKT 58 2503 DRB5*0101 DR2w.beta.2 553.01 QYIKANSKFIGITE 20 2504 The "Nomenclature" column lists the allelic designations used in Table XVIII.

TABLE-US-00007 TABLE VI HBV A01 SUPER MOTIF(With binding information) SEQ ID Conservancy Freq. Protein Position Sequence String Peptide Filed A*0101 NO: 95 19 POL 521 AICSVVRRAF XIXXXXXXXF 1 95 19 NUC 54 ALRQAILCW XLXXXXXXW 2 80 16 ENV 108 AMQWNSTTF XMXXXXXXF 3 100 20 POL 166 ASFCGSPY XSXXXXXY 26.0026 * 4 100 20 POL 166 ASFCGSPYSW XSXXXXXXXW 5 90 18 NUC 19 ASKLCLGW XSXXXXXW 6 85 17 NUC 19 ASKLCLGWLW XSXXXXXXXW 7 80 16 POL 822 ASPLHVAW XSXXXXXW 8 100 20 ENV 312 CIPIPSSW XIXXXXXW 9 100 20 ENV 312 CIPIPSSWAF XIXXXXXXXF 10 95 19 ENV 253 CLIFLLVLLDY XLXXXXXXXXY 26.0548 11 95 19 ENV 239 CLRRFIIF XLXXXXXF 12 75 15 ENV 239 CLRRFIIFLF XLXXXXXXXF 13 95 19 POL 523 CSVVRRAF XSXXXXXF 14 100 20 ENV 310 CTCIPIPSSW XTXXXXXXXW 15 90 18 NUC 31 DIDPYKEF XIXXXXXF 16 85 17 NUC 29 DLLDTASALY XLXXXXXXXY 1.0519 * 11.1000 17 95 19 ENV 196 DSWWTSLNF XSXXXXXXF 20.0120 18 95 19 NUC 43 ELLSFLPSDF XLXXXXXXXF 19 95 19 NUC 43 ELLSFLPSDFF XLXXXXXXXXF 20 95 19 POL 374 ESRLVVDF XSXXXXXF 21 95 19 POL 374 ESRLVVDFSQF XSXXXXXXXXF 22 80 16 ENV 248 FILLLCLIF XIXXXXXXF 23 80 16 ENV 246 FLFILLLCLIF XLXXXXXXXXF 24 95 19 ENV 256 FLLVLLDY XLXXXXXY 26.0027 25 95 19 POL 658 FSPTYKAF XSXXXXXF 26 90 18 X 63 FSSAGPCALRF XSXXXXXXXXF 27 100 20 ENV 333 FSWLSLLVPF XSXXXXXXXF 20.0263 28 95 19 POL 656 FTFSPTYKAF XTXXXXXXXF 20.0262 29 95 19 ENV 346 FVGLSPTVW XVXXXXXXW 30 95 19 POL 627 GLLGFAAPF XLXXXXXXF 20.0124 31 95 19 POL 509 GLSPFLLAQF XLXXXXXXXF 32 85 17 NUC 29 GMDIDPYKEF XMXXXXXXXF 26.0372 33 95 19 NUC 123 GVWIRTPPAY XVXXXXXXXY 1.0525 0.0017 34 75 15 POL 569 HLNPNKTKRW XLXXXXXXXW 35 80 16 POL 491 HLYSHPIILGF XLXXXXXXXXF 36 85 17 POL 715 HTAELLAACF XTXXXXXXXF 37 95 19 NUC 52 HTALRQAILCW XTXXXXXXXXW 38 100 20 POL 149 HTLWKAGILY XTXXXXXXXY 1.0542 * 0.0300 39 100 20 ENV 249 ILLLCLIF XLXXXXXF 40 80 16 POL 760 ILRGTSFVY XLXXXXXXY 1.0205 * 0.0017 41 90 18 ENV 188 ILTIPQSLDSW XLXXXXXXXXW 42 90 18 POL 625 IVGLLGFAAPF XVXXXXXXXXF 43 80 16 POL 503 KIPMGVGLSPF XIXXXXXXXXF 44 85 17 NUC 21 KLCLGWLW XLXXXXXW 45 75 15 POL 108 KLIMPARF XLXXXXXF 45 75 15 POL 108 KLIMPARFY XLXXXXXXY 1.0171 0.0017 47 80 16 POL 610 KLPVNRPIDW XLXXXXXXXW 48 85 17 POL 574 KTKRWGYSLNF XTXXXXXXXXF 49 95 19 POL 55 KVGNFTGLY XVXXXXXXY 1.0166 * 0.0680 50 95 19 ENV 254 LIFLLVLLDY XIXXXXXXXY 1.0899 0.0084 51 100 20 POL 109 LIMPARFY XIXXXXXY 26.0028 52 85 17 NUC 30 LLDTASALY XLXXXXXXY 1.0155 * 25.0000 53 80 16 POL 752 LLGCAANW XLXXXXXW 54 95 19 POL 628 LLGFAAPF XLXXXXXF 55 100 20 ENV 378 LLPIFFCLW XLXXXXXXW 56 100 20 ENV 378 LLPIFFCLWVY XLXXXXXXXXY 26.0549 * 57 95 19 NUC 44 LLSFLPSDF XLXXXXXXF 58 95 19 NUC 44 LLSFLPSDFF XLXXXXXXXF 59 90 18 POL 407 LLSSNLSW XLXXXXXW 60 95 19 ENV 175 LLVLQAGF XLXXXXXF 61 95 19 ENV 175 LLVLQAGFF XLXXXXXXF 20.0121 62 100 20 ENV 338 LLVPFVQW XLXXXXXW 63 100 20 ENV 338 LLVPFVQWF XLXXXXXXF 64 85 17 NUC 100 LLWFHISCLTF XLXXXXXXXXF 65 95 19 NUC 45 LSFLPSDF XSXXXXXF 66 95 19 NUC 45 LSFLPSDFF XSXXXXXXF 20.0123 67 95 19 POL 415 LSLDVSAAF XSXXXXXXF 68 95 19 POL 415 LSLDVSAAFY XSXXXXXXXY 2.0239 * 4.2000 69 100 20 ENV 336 LSLLVPFVQW XSXXXXXXXW 70 100 20 ENV 336 LSLLVPFVQWF XSXXXXXXXXF 71 95 19 X 53 LSLRGLPVCAF XSXXXXXXXXF 72 95 19 POL 510 LSPFLLAQF XSXXXXXXF 73 75 15 ENV 349 LSPTVWLSVIW XSXXXXXXXXW 74 85 17 POL 742 LSRKYTSF XSXXXXXF 75 85 17 POL 742 LSRKYTSFPW XSXXXXXXXW 76 75 15 ENV 16 LSVPNPLGF XSXXXXXXF 77 75 15 NUC 137 LTFGRETVLEY XTXXXXXXXXY 78 90 18 ENV 189 LTIPQSLDSW XTXXXXXXXW 79 90 18 ENV 189 LTIPQSLDSWW XTXXXXXXXXW 80 90 18 POL 404 LTNLLSSNLSW XTXXXXXXXXW 81 95 19 ENV 176 LVLQAGFF XVXXXXXF 82 100 20 ENV 339 LVPFVQWF XVXXXXXF 83 100 20 POL 377 LVVDFSQF XVXXXXXF 84 85 17 ENV 360 MMWYWGPSLY XMXXXXXXXY 1039.01 * 0.0810 85 75 15 X 103 MSTTDLEAY XSXXXXXXY 2.0126 * 0.8500 86 75 15 X 103 MSTTDLEAYF XSXXXXXXXF 87 95 19 POL 42 NLGNLNVSIPW XLXXXXXXXXW 88 90 18 POL 406 NLLSSNLSW XLXXXXXXW 89 95 19 POL 45 NLNVSIPW XLXXXXXW 90 75 15 ENV 15 NLSVPNPLGF XLXXXXXXXF 91 90 18 POL 738 NSVVLSRKY XSXXXXXXY 2.0123 0.0005 92 100 20 ENV 380 PIFFCLWVY XIXXXXXXY 1.0843 0.0078 93 100 20 ENV 314 PIPSSWAF XIXXXXXF 94 100 20 POL 124 PLDKGIKPY XLXXXXXXY 1.0174 * 0.0190 95 100 20 POL 124 PLDKGIKPYY XLXXXXXXXY 1.0541 * 0.1600 96 100 20 ENV 377 PLLPIFFCLW XLXXXXXXXW 97 95 19 ENV 174 PLLVLQAGF XLXXXXXXF 98 95 19 ENV 174 PLLVLQAGFF XLXXXXXXXF 99 80 16 POL 505 PMGVGLSPF XMXXXXXXF 100 85 17 POL 797 PTTGRTSLY XTXXXXXXY 1.0208 * 0.7700 101 75 15 ENV 351 PTVWLSVIW XTXXXXXXW 102 85 17 POL 612 PVNRPIDW XVXXXXXW 103 95 19 POL 685 QVFADATPTG XVXXXXXXXXW 104 90 18 POL 624 RIVGLLGF XIXXXXXF 105 75 15 POL 106 RLKLIMPARF XLXXXXXXXF 106 75 15 POL 106 RLKLIMPARFY XLXXXXXXXXY 107 95 19 POL 376 RLVVDFSQF XLXXXXXXF 20.0122 108 90 18 POL 353 RTPARVTGGVF XTXXXXXXXXF 109 100 20 POL 49 SIPWTHKVGNF XIXXXXXXXXF 110 95 19 ENV 194 SLDSWWTSLNF XLXXXXXXXXF 111 95 19 POL 416 SLDVSAAF XLXXXXXF 112 95 19 POL 416 SLDVSAAFY XLXXXXXXY 1.0186 * 17.2000 113 100 20 ENV 337 SLLVPFVQW XLXXXXXXW 114 100 20 ENV 337 SLLVPFVQWF XLXXXXXXXF 115 95 19 X 54 SLRGLPVCAF XLXXXXXXXF 20.0259 116 90 18 X 64 SSAGPCALRF XSXXXXXXXF 26.0374 117 75 15 X 104 STTDLEAY XTXXXXXY 118 75 15 X 104 STTDLEAYF XTXXXXXXF 119 75 15 ENV 17 SVPNPLGF XVXXXXXF 120 90 18 POL 739 SVVLSRKY XVXXXXXY 26.0029 121 85 17 POL 739 SVVLSRKYTSF XVXXXXXXXXF 122

90 18 ENV 190 TIPQSLDSW XIXXXXXXW 123 90 18 ENV 190 TIPQSLDSWW XIXXXXXXXW 124 100 20 POL 150 TLWKAGILY XLXXXXXXY 1.0177 * 0.0017 125 75 15 X 105 TTDLEAYF XTXXXXXF 126 85 17 POL 798 TTGRTSLY XTXXXXXY 26.0030 127 80 16 NUC 16 TVQASKLCLGW XVXXXXXXXXW 128 75 15 ENV 352 TVWLSVIW XVXXXXXW 129 85 17 POL 741 VLSRKYTSF XLXXXXXXF 130 85 17 POL 741 VLSRKYTSFPW XLXXXXXXXXW 131 85 17 POL 740 VVLSRKYTSF XVXXXXXXXF 20.0261 132 80 16 POL 759 WILRGTSF XIXXXXXF 133 80 16 POL 759 WILRGTSFVY XIXXXXXXXY 1.0572 0.0023 134 95 19 NUC 125 WIRTPPAY XIXXXXXY 26.0031 135 80 16 POL 751 WLLGCAANW XLXXXXXXW 136 95 19 POL 414 WLSLDVSAAF XLXXXXXXXF 137 95 19 POL 414 WLSLDVSAAFY XLXXXXXXXXY 26.0551 138 100 20 ENV 335 WLSLLVPF XLXXXXXF 139 100 20 ENV 335 WLSLLVPFVQW XLXXXXXXXXW 140 85 17 NUC 26 WLWGMDIDPY XLXXXXXXXY 1.0774 * 0.0810 141 95 19 ENV 237 WMCLRRFIIF XMXXXXXXXF 20.0266 142 85 17 ENV 359 WMMWYWGPS XMXXXXXXXXY 26.0552 * 143 100 20 POL 52 WTHKVGNF XTXXXXXF 144 100 20 POL 122 YLPLDKGIKPY XLXXXXXXXXY 26.0553 145 90 18 NUC 118 YLVSFGVW XLXXXXXW 146 80 16 POL 493 YSHPIILGF XSXXXXXXF 147 85 17 POL 580 YSLNFMGY XSXXXXXY 26.0032 148 148

TABLE-US-00008 TABLE VII HBV A02 SUPER MOTIF (With binding information) EQ Conser- Fre- Posi- C- ID vancy quency Protein tion Sequence P2 term Peptide AA Filed A*0201 A*0202 A*0203 A*0206 A*6802 NO: 85 17 POL 721 AACFARSRSGA A A 11 149 85 17 POL 431 AAMPHLLV A V 8 150 80 16 POL 756 AANWILRGT A T 9 151 95 19 POL 632 AAPFTQCGYPA A A 11 152 95 19 POL 521 AICSVVRRA I A 5.0025 9 0.0001 153 90 18 NUC 58 AILCWGEL I L 8 154 90 18 NUC 58 AILCWGELM I M 9 155 95 19 POL 642 ALMPLYACI L I 927.15 9 * 0.5000 0.0340 3.3000 0.2500 0.0470 156 80 16 ENV 108 AMQWNSTT M T 8 157 75 15 X 102 AMSTTDLEA M A 3.0051 9 0.0013 158 95 19 POL 690 ATPTGWGL T L 8 159 80 16 POL 690 ATPTGWGLA T A 9 160 75 15 POL 690 ATPTGWGLAI T I 10 161 95 19 POL 397 AVPNLQSL V L 8 162 95 19 POL 397 AVPNLQSLT V T 5.0026 9 0.0001 163 95 19 POL 397 AVPNLQSLTNL V L 11 164 80 16 POL 755 CAANWILRGT A T 10 165 95 19 X 61 CAFSSAGPCA A A 5.0090 10 0.0001 166 95 19 X 61 CAFSSAGPCAL A L 11 167 90 18 X 69 CALRFTSA A A 8 168 100 20 ENV 312 CIPIPSSWA I A 5.0007 9 0.0010 169 80 16 ENV 312 CIPIPSSWAFA I A 11 170 90 18 POL 533 CLAFSYMDDV L V 1.0559 10 0.0008 171 90 18 POL 533 CLAFSYMDDVV L V 11 172 85 17 NUC 23 CLGWLWGM L M 8 173 85 17 NUC 23 CLGWLWGMDI L I 3.0210 10 0.0093 174 100 20 ENV 253 CLIFLLVL L L Chisari 6 0.0002 175 4.011 100 20 ENV 253 CLIFLLVLL L L 1.0836 9 0.0006 176 95 19 ENV 239 CLRRFIIFL L L 1.0829 0.0002 177 75 15 ENV 239 CLRRFIIFLFI L I Chisari 11 0.0004 178 4.055 90 18 NUC 107 CLTFGRET L T 8 179 90 18 NUC 107 CLTFGRETV L V 1.0160 9 0.0001 180 100 20 ENV 310 CTCIPIPSSWA T A 11 181 95 19 POL 689 DATPTGWGL A L 5.0027 9 0.0001 182 80 16 POL 689 DATPTGWGLA A A 10 183 75 15 POL 689 DATPTGWGLAI A I 11 184 90 18 NUC 31 DIDPYKEFGA I A 10 185 85 17 NUC 29 DLLDTASA L A 8 186 85 17 NUC 29 DLLDTASAL L L 1.0154 9 0.0001 187 95 19 POL 40 DLNLGNLNV L V 927.30 9 0.0004 188 95 19 POL 40 DLNLGNLNVSI L I 11 189 80 16 NUC 32 DTASALYREA T A 10 190 80 16 NUC 32 DTASALYREAL T L 11 191 95 19 X 14 DVLCLRPV V V 8 192 95 19 X 14 DVLCLRPVGA V A 5.0091 10 0.0001 193 90 18 POL 541 DVVLGAKSV V V 1.0190 9 0.0003 194 100 20 POL 17 EAGPLEEEL A L 5.0028 9 0.0001 195 80 16 X 122 ELGEERL L L 8 196 90 18 POL 718 ELLAACFA L A 8 197 75 15 NUC 142 ETVLEYLV T V 8 198 95 19 POL 687 FADATPTGWGL A L 11 199 85 17 POL 724 FARSRSGA A A 8 200 80 16 POL 821 FASPLHVA A A 8 201 95 19 POL 396 FAVPNLQSL A L 9 202 95 19 POL 396 FAVPNLQSLT A T 5.0083 10 0.0003 203 80 16 ENV 243 FIIFLFIL I L Chisari 8 0.0006 204 4.047 80 16 ENV 243 FIIFLFILL I L 1.0830 9 0.0002 205 80 16 ENV 243 FIIFLFILLL I L 1.0894 10 0.0012 206 80 16 ENV 248 FILLLCLI I I Chisari 8 0.0003 207 4.048 80 16 ENV 248 FILLLCLIFL I L 1.0895 10 * 0.0280 208 80 16 ENV 248 FILLLCLIFLL I L Chisari 11 0.0010 209 4.049 80 16 ENV 246 FLFILLLCL L L 1.0832 9 0.0002 210 80 16 ENV 246 FLFILLLCLI L I 3.0206 10 0.0013 211 75 15 ENV 171 FLGPLLVL L L 8 212 75 15 ENV 171 FLGPLLVLQA L A 3.0205 10 * 0.0190 213 95 19 POL 513 FLLAQFTSA L A 1069.07 9 * 0.2400 214 95 19 POL 513 FLLAQFTSAI L I 11147.13 10 * 0.2100 0.0320 7.0000 0.1100 0.660 215 95 19 POL 562 FLLSLGIHL L L 927.11 9 * 0.6500 0.0010 0.0100 0.1100 0.0035 216 80 16 ENV 183 FLLTRILT L T 8 217 80 16 ENV 183 FLLTRILTI L I 777.03 9 * 0.5100 0.0430 8.0000 0.2000 0.0010 218 95 19 ENV 256 FLLVLLDYQGM L M 11 219 100 20 POL 363 FLVDKNPHNT L T 5.0084 10 0.0012 220 95 19 POL 656 FTFSPTYKA T A 1147.15 9 * 0.0056 0.0150 0.0031 0.8000 7.3000 221 95 19 POL 656 FTFSPTYKAFL T L 11 222 95 19 POL 59 FTGLYSST T T 6 223 90 18 POL 59 FTGLYSSTV T V 20.0118 9 0.0005 224 95 19 POL 635 FTQCGYPA T A 8 225 95 19 POL 635 FTQCGYPAL T L 5.0031 9 0.0009 226 95 19 POL 635 FTQCGYPALM T M 5.0085 10 0.0024 227 95 19 POL 518 FTSAICSV T V 8 228 95 19 POL 518 FTSAICSVV T V 5.0032 9 0.0090 229 95 19 ENV 346 FVGLSPTV V V 8 230 95 19 ENV 346 FVGLSPTVWL V L 1.0931 10 0.0008 231 90 18 X 132 FVLGGCRHKL V L Chisari 10 0.0030 232 4.114 90 18 X 132 FVLGGCRHKLV V V 11 233 95 19 ENV 342 FVQWFVGL V L 8 234 95 19 ENV 342 FVQWFVGLSPT V T 11 235 90 18 POL 766 FVYVPSAL V L 8 236 90 18 POL 766 FVYVPSALNPA V A 11 237 95 19 X 50 GAHLSLRGL A L 5.0040 9 0.0001 238 90 18 X 50 GAHLSLRGLPV A V 11 239 85 17 POL 545 GAKSVQHL A L 8 240 85 17 POL 545 GAKSVQHLESL A L 11 241 75 15 POL 567 GIHLNPNKT I T 9 242 90 18 POL 155 GILYKRET I T 8 243 90 18 POL 155 GILYKRETT I T 9 244 85 17 POL 682 GLCQVFADA L A 1142.04 9 * 0.0024 245 85 17 POL 682 GLCQVFADAT L T 10 246 95 19 POL 627 GLLGFAAPFT L T 5.0086 10 0.0049 247 85 17 ENV 62 GLLGWSPQA L A 1142.07 9 * 0.4000 0.0003 0.0350 0.2600 0.0005 248 95 19 X 57 GLPVCAFSSA L A 5.0092 10 0.0008 249 95 19 POL 509 GLSPFLLA L A 8 250 95 19 POL 509 GLSPFLLAQFT L T 11 251 100 20 ENV 348 GLSPTVWL L L Chisari 8 0.0036 252 4.012 75 15 ENV 348 GLSPTVWLSV L V 1.0518 10 * 0.2600 253 75 15 ENV 348 GLSPTVWLSVI L I Chisari 11 0.0036 254 4.031 90 18 ENV 265 GMLPVCPL M L 8 255 90 18 POL 735 GTDNSVVL T L 8 256 75 15 ENV 13 GTNLSVPNPL T L 10 257 80 16 POL 763 GTSFVYVPSA T A 10 258 80 16 POL 763 GTSFVYVPSAL T L 11 259 80 16 POL 507 GVGLSPFL V L 8 260 80 16 POL 507 GVGLSPFLL V L Chisari 9 0.0002 261 4.082 80 16 POL 507 GVGLSPFLLA V A 10 262

95 19 NUC 123 GVWIRTPPA V A 3.0040 9 0.0030 263 90 18 NUC 104 HISCLTFGRET I T 11 264 80 16 POL 435 HLLVGSSGL L L 927.43 9 0.0031 265 90 18 X 52 HLSLGLPV L V 927.02 9 0.0014 266 90 18 X 52 HLSLRGLPVCA L A 11 267 80 16 POL 491 HLYSHPII L I 17.0256 8 268 80 16 POL 491 HLYSHPIIL L L 927.47 9 * 0.2200 0.0003 0.9300 0.1700 0.0530 269 85 17 POL 715 HTAELLAA T A 8 270 85 17 POL 715 HTAELLAACFA T A 11 271 100 20 NUC 52 HTALRQAI T I 8 272 95 19 NUC 52 HTALRQAIL T L 5.0021 9 0.0001 273 100 20 POL 149 HTLWKAGI T I 8 274 100 20 POL 149 HTLWKAGIL T L 5.0033 9 0.0001 275 80 16 ENV 244 IIFLFILL I L Chisari 8 0.0004 276 4.051 80 16 ENV 244 IIFLFILLL I L 1.0831 9 0.0002 277 80 16 ENV 244 IIFLFILLLCL I L Chisari 11 0.0002 278 4.052 80 16 POL 497 IILGFRKI I I 8 279 80 16 POL 497 IILGFRKIPM I M 10 280 90 18 NUC 59 ILCWGELM L M 8 281 80 16 POL 498 ILGFRKIPM L M 3.0016 9 0.0002 282 100 20 ENV 249 ILLLCLIFL L L 1137.04 9 * 0.0015 283 100 20 ENV 249 ILLLCLIFLL L L 1069.08 10 * 0.0190 0.0001 0.0002 0.1300 0.0015 284 100 20 ENV 249 ILLLCLIFLLV L V Chisari 11 0.0056 285 4.013 80 16 POL 760 ILRGTSFV L V 8 286 80 16 POL 760 ILRGTSFVYV L V 1.0573 10 0.0160 287 100 20 NUC 139 ILSTLPET L T 8 288 100 20 NUC 139 ILSTLPETT L T 5.0022 9 0.0001 289 100 20 NUC 139 ILSTLPETTV L V 1069.14 10 * 0.0210 0.0085 0.0770 0.3100 0.0067 290 100 20 NUC 139 ILSTLPETTVV L V 11 291 95 19 ENV 188 ILTIPQSL L L 8 292 90 18 POL 156 ILYKRETT L T 8 293 90 18 POL 625 IVGLLGFA V A 8 294 90 18 POL 625 IVGLLGFAA V A 3.0041 9 0.0009 295 90 18 POL 153 KAGILYKRET A T 10 296 90 18 POL 153 KAGILYKRETT A T 11 297 80 16 POL 503 KIPMGVGL I L 8 298 85 17 NUC 21 KLCLGWLWGM L M 1142.02 10 * 0.0001 299 95 19 POL 489 KLHLYSHPI L I 927.46 9 * 0.0690 0.0340 2.7000 0.5900 0.0015 300 80 16 POL 489 KLHLYSHPII L I 10 301 80 16 POL 489 KLHLYSHPIIL L L 11 302 80 16 POL 610 KLPVNRPI L I 8 303 95 19 POL 574 KTKRWGYSL T L 5.0034 9 0.0001 304 85 17 POL 620 KVCQRIVGL V L 1.0198 9 0.0003 305 85 17 POL 620 KVCQRIVGLL V L 1.0567 10 0.0001 306 95 19 POL 55 KVGNFTGL V L 17.0116 8 307 85 17 X 91 KVLHKRTL V L 8 308 85 17 X 91 KVLHKRTLGL V L Chisari 10 0.0004 309 4.115 90 18 POL 534 LAFSYMDDV A V 20.0119 9 0.0002 310 90 18 POL 534 LAFSYMDDVV A V 20.0257 10 0.0003 311 90 18 POL 534 LAFSYMDDVVL A L 11 312 95 19 POL 515 LAQFTSAI A I 8 313 95 19 POL 515 LAQFTSAICSV A V 11 314 100 20 ENV 254 LIFLLVLL I L Chisari 8 0.0025 315 4.014 95 19 POL 514 LLAQFTSA L A 8 316 95 19 POL 514 LLAQFTSAI L I 1069.05 9 * 0.1000 0.2700 3.7000 0.2600 0.7900 317 100 20 ENV 251 LLCLIFLL L L Chisari 8 0.0004 318 4.015 100 20 ENV 251 LLCLIFLLV L V 1137.03 9 * 0.0048 319 100 20 ENV 251 LLCLIFLLVL L L 1.0898 10 0.0075 320 100 20 ENV 251 LLCLIFLLVLL L L Chisari 11 0.0013 321 4.016 85 17 NUC 30 LLDTASAL L L 8 . 322 95 19 ENV 260 LLDYQGML L L Chisari 8 0.0004 323 4.021 90 18 ENV 260 LLDYQGMLPV L V 1137.02 10 * 0.0980 0.0001 0.0200 0.6700 0.0009 324 80 16 POL 752 LLGCAANWI L I 927.22 9 0.0011 325 80 16 POL 752 LLGCAANWIL L L 1.0912 10 * 0.0140 326 95 19 POL 628 LLGFAAPFT L T 5.0035 9 0.0008 327 85 17 ENV 63 LLGWSPQA L A 8 328 75 15 ENV 63 LLGWSPQAQGI L I 11 329 100 20 ENV 250 LLLCLIFL L L Chisari 8 0.0006 330 4.017 100 20 ENV 250 LLLCLIFLL L L 1090.05 9 * 0.0085 331 100 20 ENV 250 LLLCLIFLLV L V 1137.01 10 * 0.0036 332 100 20 ENV 250 LLLCLIFLLVL L L Chisari 11 0.0005 333 4.018 100 20 ENV 378 LLPIFFCL L L Chisari 8 0.0055 334 4.019 100 20 ENV 378 LLPIFFCLWV L V 1069.10 10 * 0.0320 0.0008 0.0150 0.8000 0.0005 335 95 19 POL 563 LLSLGIHL L L 8 336 90 18 POL 407 LLSSNLSWL L L 927.41 9 * 0.0110 0.0780 3.9000 0.2700 0.0100 337 90 18 POL 407 LLSSNLSWLSL L L 11 338 80 16 ENV 184 LLTRILTI L I Chisari 8 0.0026 339 4.053 80 16 POL 436 LLVGSSGL L L 8 340 95 19 ENV 257 LLVLLDYQGM L M 3.0207 10 0.0050 341 95 19 ENV 257 LLVLLDYQGML L L 11 342 90 18 ENV 175 LLVLOAGFFL L L 1090.06 10 0.0310 0.0037 0.0045 0.1500 0.0110 343 90 18 ENV 175 LLVLQAGFFLL L L Chisari 11 0.0074 344 4.028 95 19 ENV 338 LLVPFVQWFV L V 1069.06 10 * 0.6700 0.3800 1.7000 0.2900 0.1400 345 90 18 NUC 100 LLWFHISCL L L 1142.01 9 * 0.0130 0.0002 0.0420 0.3100 0.0098 346 85 17 NUC 100 LLWFHISCLT L T 10 347 95 19 POL 643 LMPLYACI M I 17.0130 8 348 95 19 NUC 108 LTFGRETV T V 8 349 75 15 NUC 137 LTFGRETVL T L 9 350 90 18 POL 404 LTNLLSSNL T L 9 351 80 16 ENV 185 LTRILTIPQSL T L 11 352 85 17 POL 99 LTVNEKRRL T L 9 353 100 20 POL 364 LVDKNPHNT V T 5.0036 9 0.0001 354 95 19 ENV 258 LVLLDYQGM V M 3.0034 9 0.0001 355 95 19 ENV 258 LVLLDYQGML V L 1.0515 10 0.0001 356 90 18 ENV 176 LVLQAGFFL V L 1.0827 9 0.0096 357 90 18 ENV 176 LVLQAGFFLL V L 1132.17 10 * 0.0022 358 90 18 ENV 176 LVLQAGFFLLT V T 11 359 95 19 ENV 339 LVPFVQWFV V V 1132.01 9 * 0.0420 0.0150 0.0048 0.7900 2.8000 360 95 19 ENV 339 LVPFVQWFVGL V L 11 361 90 18 NUC 119 LVSFGVWI V I Chisari 8 0.0004 362 4.078 90 18 NUC 119 LVSFGVWIRT V T 10 363 85 17 ENV 360 MMWYWGPSL M L 1039.03 9 * 0.6400 364 100 20 NUC 136 NAPILSTL A L 8 365 100 20 NUC 136 NAPILSTLPET A T 11 366 95 19 POL 42 NLGNLNVSI L I 3.0008 9 0.0047 367 90 18 POL 406 NLLSSNLSWL L L 1.0549 10 0.0016 368 95 19 POL 45 NLNVSIPWT L T 5.0037 9 0.0005 369 100 20 POL 400 NLQSLTNL L L 8 370 100 20 POL 400 NLQSLTNLL L L 927.40 9 0.0047 371 75 15 ENV 15 NLSVPNPL L L 8 372 90 18 POL 411 NLSWLSLDV L V 927.42 9 * 0.0650 0.0051 0.6400 0.1600 0.0990 373 90 18 POL 411 NLSWLSLDVSA L A 11 374

100 20 POL 47 NVSIPWTHKV V V 1.0532 10 0.0001 375 100 20 POL 430 PAAMPHLL A L 8 376 85 17 POL 430 PAAMPHLLV A V 9 377 90 18 POL 775 PADDPSRGRL A L 10 378 90 18 ENV 131 PAGGSSSGT A T 9 379 90 18 ENV 131 PAGGSSSGTV A V 10 380 95 19 POL 641 PALMPLYA A A 8 381 95 19 POL 641 PALMPLYACI A I 5.0087 10 0.0001 382 75 15 X 145 PAPCNFFT A T 8 383 75 15 X 145 PAPCNFFTSA A A 10 384 80 16 X 11 PARDVLCL A L 8 385 75 15 X 11 PARDVLCLRPV A V 11 386 90 18 POL 355 PARVTTGGV A V 8 387 90 18 POL 355 PARVTGGVFL A L 10 388 90 18 POL 355 PARVTGGVFLV A V 11 389 95 19 NUC 130 PAYRPPNA A A 8 390 95 19 NUC 130 PAYRPPNAPI A I 5.0081 10 0.0001 391 95 19 NUC 130 PAYRPPNAPIL A L 11 392 85 17 POL 616 PIDWKVCQRI I I Chisari 10 0.0001 393 4.091 85 17 POL 616 PIDWKVCQRIV I V 11 394 100 20 ENV 380 PIFFCLWV I V 8 395 100 20 ENV 380 PIFFCLWVYI I I Chisari 10 0.0004 396 3.074 85 17 POL 713 PIHTAELL I L 8 397 85 17 POL 713 PIHTAELLA I A 9 398 85 17 POL 713 PIHTAELLAA I A 10 399 80 16 POL 496 PIILGFRKI I I 927.48 9 0.0001 400 80 16 POL 496 PIILGFRKIPM I M 11 401 100 20 NUC 138 PILSTLPET I T 5.0023 9 0.0001 402 100 20 NUC 138 PILSTLPETT I T 5.0082 10 0.0001 403 100 20 NUC 138 PILSTLPETTV I V Chisari 11 0.0001 404 5.125 80 16 ENV 314 PIPSSWAFA I A 9 405 95 19 POL 20 PLEEELPRL L L 927.29 9 0.0003 406 90 18 POL 20 PLEEELPRLA L A 3.0225 10 0.0001 407 95 19 ENV 10 PLGFFPDHQL L L 1.0511 10 0.0002 408 100 20 POL 427 PLHPAAMPHL L L 1.0560 10 0.0001 409 100 20 POL 427 PLHPAAMPHLL L L 11 410 100 20 ENV 377 PLLPIFFCL L L 1069.13 9 * 0.0650 0.0001 0.0018 0.1100 0.0047 411 100 20 ENV 377 PLLPIFFCLWV L V 11 412 90 18 ENV 174 PLLVLQAGFFL L L Chisari 11 0.0008 413 4.029 80 16 POL 711 PLPIHTAEL L L 927.19 9 0.0004 414 80 16 POL 711 PLPIHTAELL L L 1.0569 10 0.0001 415 80 16 POL 711 PLPIHTAELLA L A 11 416 75 15 POL 2 PLSYQHFRKL L L 1.0527 10 0.0001 417 75 15 POL 2 PLSYQHFRKLL L L 11 418 85 17 POL 98 PLTVNEKRRL L L 1.0536 10 0.0001 419 80 16 POL 505 PMGVGLSPFL M L 1.0557 10 0.0001 420 80 16 POL 505 PMGVGLSPFLL M L 11 421 75 15 POL 692 PTGWGLAI T I 8 422 80 16 ENV 219 PTSNHSPT T T 8 423 85 17 POL 797 PTTGRTSL T L 8 424 85 17 POL 797 PTTGRTSLYA T A 10 425 80 16 NUC 15 PTVQASKL T L 8 428 80 16 NUC 15 PTVQASKLCL T L 10 427 75 15 ENV 351 PTVWLSVI T I 8 428 75 15 ENV 351 PTVWLSVIWM T M 10 429 95 19 X 59 PVCAFSSA V A 8 430 85 17 POL 612 PVNRPIDWKV V V 1.0565 10 0.0002 431 95 19 POL 654 QAFTFSPT A T 8 432 95 19 POL 654 QAFTFSPTYKA A A 11 433 95 19 ENV 179 QAGFFLLT A T 8 434 80 16 ENV 179 QAGFFLLTRI A I 10 435 80 16 ENV 179 QAGFFLLTRIL A L 11 436 90 18 NUC 57 QAILCWGEL A L 9 437 90 18 NUC 57 QAILCWGELM A M 10 438 95 19 ENV 107 OAMQWNST A T 8 439 80 16 ENV 107 QAMQWNSTT A T 9 440 80 16 NUC 18 QASKLCLGWL A L 10 441 80 16 X 8 QLDPARDV L V Chisari 8 0.0001 442 4.116 80 16 X 8 QLDPARDVL L L 927.01 9 0.0001 443 80 16 X 8 QLDPARDVLCL L L Chisari 11 0.0001 444 4.073 90 18 NUC 99 QLLWFHISCL L L 1142.03 10 * 0.0060 445 85 17 NUC 99 QLLWFHISCLT L T 11 446 95 19 POL 685 QVFADATPT V T 5.0038 9 0.0001 447 95 19 POL 528 RAFRHCLA A A 8 448 80 16 ENV 187 RILTIPQSL I L Chisari 9 0.0010 449 4.054 90 18 POL 624 RIVGLLGFA I A 9 450 90 18 POL 624 RIVGLLGFAA I A 10 451 75 15 POL 106 RLKLIMPA L A 8 452 90 18 POL 353 RTPARVTGGV T V 10 453 95 19 NUC 127 RTPPAYRPPNA T A 11 454 95 19 POL 36 RVAEDLNL V L 8 455 90 18 POL 36 RVAEDLNLGNL V L 11 456 80 16 POL 818 RVHFASPL V L 8 457 75 15 POL 818 RVHFASPLHV V V 1.0576 10 0.0001 458 75 15 POL 818 RVHFASPLHVA V A 11 459 100 20 POL 357 RVTGGVFL V L 8 460 100 20 POL 357 RVTGGVFLV V V 1.0181 9 0.0041 461 90 18 X 65 SAGPCALRFT A T 10 462 95 19 POL 520 SAICSVVRRA A A 5.0088 10 0.0001 463 90 18 NUC 35 SALYREAL A L 8 464 100 20 POL 49 SIPWTHKV I V 8 465 95 19 ENV 194 SLDSWWTSL L L F126.64 9 466 75 15 POL 565 SLGIHLNPNKT L T 11 467 95 19 ENV 337 SLLVPFVQWFV L V 11 468 75 15 POL 581 SLNFMGYV L V 8 469 75 15 POL 581 SLNFMGYVI L I 927.12 9 0.0038 470 95 19 X 54 SLRGLPVCA L A 3.0030 9 0.0007 471 90 18 POL 403 SLTNLLSSNL L L 1.0548 10 0.0014 472 75 15 ENV 280 STGPCKTCT T T 9 473 100 20 NUC 141 STLPETTV T V 8 474 100 20 NUC 141 STLPETTVV T V 5.0024 9 0.0019 475 80 16 ENV 85 STNRQSGRQPT T T 11 476 85 17 POL 548 SVQHLESL V L 8 477 80 16 ENV 330 SVRFSWLSL V L Chisari 9 0.0001 478 4.025 80 16 ENV 330 SVRFSWLSLL V L Chisari 10 0.0004 479 4.026 80 16 ENV 330 SVRFSWLSLLV V V 11 480 90 18 POL 739 SVVLSRKYT V T 9 481 95 19 POL 524 SVVRRAFPHCL V L 11 482 85 17 POL 716 TAELLAACFA A A 10 483 95 19 NUC 53 TALRQAIL A L 8 484 80 16 NUC 33 TASALYREA A A 9 485 80 16 NUC 33 TASALYREAL A L 10 486 90 18 ENV 190 TIPQSLDSWWT I T 11 487 100 20 NUC 142 TLPETTVV L V 8 488 100 20 POL 150 TLWKAGIL L L 8 489 85 17 POL 798 TTGRTSLYA T A 9 490 75 15 ENV 278 TTSTGPCKT T T 9 491 75 15 ENV 278 TTSTGPCKTCT T T 11 492 85 17 POL 100 TVNEKRRL V L 8 493 80 16 NUC 16 TVQASKLCL V L 1.0365 9 0.0002 494

75 15 ENV 352 TVWLSVIWM V M 3.0035 9 0.0002 495 95 19 POL 37 VAEDLNLGNL A L 5.0089 10 0.0001 496 95 19 X 15 VLCLRPVGA L A 3.0028 9 0.0014 497 85 17 POL 543 VLGAKSVQHL L L 1.0560 10 0.0001 498 90 18 X 133 VLGGCRHKL L L 927.08 9 0.0009 499 90 18 X 133 VLGGCRHKLV L V 1.0589 10 0.0001 500 85 17 X 92 VLHKRTLGL L L 927.03 9 0.0012 501 95 19 ENV 259 VLLDYQGM L M 17.0107 8 502 95 19 ENV 259 VLLDYQGML L L 1069.09 9 * 0.0440 0.0001 0.0210 0.9000 0.0002 503 90 18 ENV 259 VLLDYQGMLPV L V 1147.14 11 * 0.5800 0.2200 4.9000 0.3400 0.0170 504 95 19 ENV 177 VLQAGFFL L L Chisari 6 0.0019 505 4.027 95 19 ENV 177 VLQAGFFLL L L 1013.14 9 * 0.0660 506 95 19 ENV 177 VLQAGFFLLT L T 5.0066 10 0.0011 507 100 20 POL 358 VTGGVFLV T V 8 508 90 18 POL 542 VVLGAKSV V V 8 509 80 16 POL 542 VVLGAKSVQHL V L 11 510 90 18 POL 740 VVLSRKYT V T 8 511 95 19 POL 525 VVRRAFPHCL V L 2.0217 10 0.0003 512 95 19 POL 525 VVRRAFPHCLA V A 11 513 80 16 POL 759 WILRGTSFV I V 927.24 9 * 0.0270 514 80 16 POL 759 WILRGTSFVYV I V 11 515 80 16 POL 751 WLLGCAANWI L I Chisari 10 0.0053 516 4.104 80 16 POL 751 WLLGCAANWIL L L 11 517 100 20 POL 414 WLSLDVSA L A 8 518 95 19 POL 414 WLSLDVSAA L A 3.0023 9 0.0059 519 100 20 ENV 335 WLSLLVPFV L V 1013.0102 9 * 1.1000 0,0380 7.2000 0.3600 0.0310 520 95 19 ENV 237 WMCLRRFI M I 8 521 95 19 ENV 237 WMCLRRFII M I 1147.10 9 * 0.0005 522 95 19 ENV 237 WMCLRRFIIFL M L Chisari 11 0.0019 523 4.024 85 17 ENV 359 WMMWYWGPSL M L 1137.05 10 * 0.0009 524 100 20 POL 52 WTHKVGNFT T T 5.0039 9 0.0001 525 95 19 POL 52 WTHKVGNFTGL T L 11 526 100 20 POL 147 YLHTLWKA L A 8 527 100 20 POL 147 YLHTLWKAGI L I 1069.11 10 * 0.0160 0.0005 0.5600 0.1000 0.0320 528 100 20 POL 147 YLHTLWKAGIL L L 11 529 100 20 POL 122 YLPLDKGI L I 8 530 90 18 NUC 118 YLVSFGVWI L I 1090.12 9 * 0.3800 531 90 18 NUC 118 YLVSFGVWIRT L T 11 532 90 18 POL 538 YMDDVVLGA M A 1090.14 9 * 0.0250 0.0001 0.0024 0.1000 0.0002 533 85 17 POL 746 YTSFPWLL T L 8 534 75 15 POL 746 YTSFPWLLGCA T A 11 535 90 18 POL 768 YVPSALNPA V A 3.0042 9 0.0039 536 388

TABLE-US-00009 TABLE VIII HBV A03 SUPER MOTIF (With binding Information) EQ Conser- Fre- Posi- C- ID vancy quency Protein tion Sequence P2 term Peptide AA Filed A*0201 A*0202 A*0203 A*0206 A*6802 NO: 65 17 POL 721 AACFARSR A R 26.0003 8 0.0004 0.0003 0.0056 0.0035 0.0014 537 95 19 POL 521 AICSVVRR I R 26.0004 8 -0.0002 0.0003 0.0014 -0.0009 0.0006 538 90 18 POL 772 ALNPADDPSR L R 1.1090 10 0.0003 0.0001 539 85 17 X 70 ALRFTSAR L R 26.0005 8 0.0047 0.0009 0.0450 0.0230 0.0004 540 80 16 POL 822 ASPLHVAWR S R 9 641 75 15 ENV 84 ASTNRQSGR S R 1150.60 9 0.0009 0.0002 0.0088 0.0008 0.0001 542 80 16 POL 755 CAANWILR A R 8 543 85 17 X 69 CALRFTSAR A R 26.0149 9 * 0.0034 0.0230 1.5000 8.0000 0.7300 644 90 18 X 17 CLRPVGAESR L R 1.1093 10 0.0011 0.0001 545 100 20 NUC 48 CSPHHTALR S R 5.0055 9 * 0.0029 0.0001 0.0520 0.0250 0.0440 546 85 17 NUC 29 DLLDTASALYR L R 26.0530 11 0.0042 -0.0003 -0.0012 3.7000 0.0410 547 85 17 NUC 32 DTASALYR T R 26.0006 8 0.0004 -0.0002 -0.0009 0.0018 0.0009 548 95 19 POL 17 EAGPLEEELPR A R 26.0531 11 -0.0009 -0.0003 -0.0012 0.0015 0.0110 549 90 18 POL 718 ELLAACFAR L R 1.0988 9 0.0002 0.0004 550 65 17 POL 718 ELLAACFARSR L R 26.0532 11 0.0062 0.0016 0.0200 0.2000 0.1600 551 95 19 NUC 174 ETTVVRRR T R 26.0007 8 0.0003 -0.0002 -0.0009 0.1400 0.0027 552 80 16 NUC 174 ETTVVRRRGR T R 1.1073 10 0.0003 0.0001 553 80 16 POL 821 FASPLHVAWR A R 10 554 90 18 X 63 FSSAGPCALR S R 10 555 95 19 POL 656 FTFSPTYK T K 1147.19 8 * 0.0100 0.0100 0.0023 0.2100 0.0590 556 95 19 POL 518 FTSAICSVVR T R 1.1085 10 0.0003 0.0003 557 95 19 POL 518 FTSAICSVVRR T R 26.0533 11 0.0065 0.0092 0.0170 0.0350 1.5000 558 90 18 X 132 FVLGGCRHK V K 1090.03 9 * 0.0430 0.0090 559 75 15 POL 567 GIHLNPNK I K 8 560 75 15 POL 567 GIHLNPNKTK I K 1.0563 10 0.0025 0.0011 0.0009 0.0009 0.0003 561 75 15 POL 567 GIHLNPNKTKR I R 11 562 85 17 NUC 29 GMDIDPYK M K 26.0009 8 0.0006 0.0004 -0.0009 -0.0009 0.0001 563 90 18 POL 735 GTDNSVVLSR T R 1090.04 10 * 0.0010 0.0420 0.0030 0.0019 0.0008 564 90 18 POL 735 GTDNSVVLSRK T K 1147.17 11 * 0.0140 0.5600 -0.0002 -0.0006 0.0001 565 95 19 NUC 123 GVWIRTPPAYR V R 26.0535 11 * 0.1900 0.1700 6.8000 0.7300 0.6600 566 90 18 NUC 104 HISCLTFGR I R 1069.18 9 * 0.0160 0.0065 567 75 15 POL 569 HLNPNKTK L K 8 568 75 15 POL 569 HLNPNKTKR L R 1.0983 9 * 0.0025 0.0001 569 100 20 POL 149 HTLWKAGILYK T K 1147.16 11 * 0.5400 0.4400 0.0370 0.0720 0.1900 570 90 18 NUC 105 ISCLTFGR S R 26.0010 8 0.0004 0.0002 0.0017 -0.0009 0.0017 571 100 20 POL 153 KAGILYKR A R 26.0011 8 0.0002 -0.0002 0.0015 -0.0009 0.0001 572 80 16 POL 610 KLPVNRPIDWK L K 11 573 75 15 X 130 KVFVLGGCR V R 1.0993 9 * 0.0420 0.0620 0.6000 0.0710 0.0030 574 85 17 POL 720 LAACFARSR A R 20.0129 9 * 0.0058 0.0065 575 90 18 POL 719 LLAACFAR L R 26.0012 8 0.0024 0.0003 0.0015 0.0029 0.0064 576 85 17 POL 719 LLAACFARSR L R 10 577 85 17 NUC 30 LLDTASALYR L R 1.1070 10 0.0050 0.0002 578 80 16 POL 752 LLGCAANWILR L R 11 579 75 15 POL 564 LSLGIHLNPNK S K 11 580 95 19 NUC 169 LSTLPETTVVR S R 26.0537 11 -0.0009 0.0008 -0.0012 -0.0023 0.0078 581 75 15 POL 3 LSYQHFRK S K 8 582 85 17 POL 99 LTVNEKRR T R 26.0013 8 -0.0002 -0.0002 -0.0009 -0.0009 0.0001 583 90 18 NUC 119 LVSFGVWIR V R 1090.08 9 * 0.0028 0.0120 584 100 20 POL 377 LVVDFSQFSR V R 1069.20 10 * 0.0016 0.3600 0.0260 0.2300 0.4900 585 75 15 X 103 MSTTDLEAYFK S K 11 586 90 18 NUC 75 NLEDPASR L R 26.0014 8 -0.0002 -0.0002 -0.0009 -0.0009 0.0001 587 95 19 POL 45 NLNVSIPWTHK L K 26.0538 11 -0.0009 0.0005 -0.0012 -0.0023 0.0019 588 90 18 POL 738 NSVVLSRK S K 26.0015 8 0.0006 0.0010 -0.0009 -0.0009 0.0007 589 100 20 POL 47 NVSIPWTHK V K 1069.16 9 * 0.0820 0.0570 0.0002 0.0100 0.0320 590 90 18 POL 775 PADDPSRGR A R 1150.35 9 0.0008 0.0002 0.0004 0.0015 0.0002 591 80 16 X 11 PARDVLCLR A R 1150.36 9 0.0002 0.0002 0.0100 0.0180 0.0002 592 75 15 ENV 83 PASTNRQSGR A R 10 593 90 18 POL 616 PIDWKVCQR I R 1.0985 9 0.0002 0.0005 594 80 16 POL 496 PIILGFRK I K 8 595 95 19 POL 20 PLEEELPR L R 26.0016 8 0.0002 -0.0002 -0.0009 -0.0009 0.0001 596 100 20 POL 2 PLSYQHFR L R 26.0017 8 -0.0002 -0.0002 -0.0009 -0.0009 0.0001 597 75 15 POL 2 PLSYQHFRK L K 1.0161 9 0.0011 0.0031 0.0006 0.0008 0.0002 598 85 17 POL 98 PLTVNEKR L R 26.0018 8 0.0002 -0.0002 -0.0009 -0.0009 0.0001 599 85 17 POL 98 PLTVNEKRR L R 1.0974 9 0.0008 0.0005 0.0004 0.0027 0.0002 600 90 18 X 20 PVGAESRGR V R 1.0990 9 0.0002 0.0005 0.0004 0.0043 0.0002 601 85 17 POL 612 PVNRPIDWK V K 1142.06 9 * 0.0310 0.1400 0.0002 0.0006 0.0009 602 95 19 POL 654 QAFTFSPTYK A K 1090.10 10 * 0.0450 0.5400 0.0010 0.0057 1.2000 603 80 16 ENV 179 QAGFFLLTR A R 9 604 75 15 NUC 169 QSPRRRRSQSR S R 28.0839 11 605 80 16 POL 189 QSSGILSR S R 8 606 75 15 POL 106 RLKLIMPAR L R 1.0975 9 * 0.0950 0.0002 3.1000 0.0490 0.0002 607 75 15 X 128 RLKVFVLGGCR L R 11 608 95 19 POL 376 RLVVDFSQFSR L R 26.0639 1 * 0.2800 3.8000 2.6000 1.2000 6.1000 609 95 19 NUC 183 RSPRRRTPSPR S R 26.0540 11 -0.0007 -0.0003 0.0190 -0.0023 0.0003 610 75 15 NUC 167 RSQSPRRR S R 8 611 75 15 NUC 167 RSQSPRRRR S R 9 612 95 19 NUC 188 RTPSPRRR T R 26.0019 8 -0.0002 -0.0002 0.0033 0.0014 0.0002 613 95 19 NUC 188 RTPSPRRRR T R 1.0971 9 * 0.0054 0.0005 0.2000 0.0016 0.0003 614 100 20 POL 357 RVTGGVFLVDK V K 1147.18 11 * 0.0190 0.0290 -0.0002 -0.0003 0.0001 615 90 18 X 65 SAGPCALR A R 26.0020 8 -0.0002 0.0020 0.0029 0.0024 0.0360 616 95 19 POL 520 SAICSVVR A R 26.0021 8 -0.0002 0.0071 0.0280 0.0081 0.0690 617 95 19 POL 520 SAICSVVRR A R 1090.11 9 * 0.0058 0.2100 0.1500 0.0650 0.3800 618 90 18 POL 771 SALNPADDPSR A R 26.0542 11 -0.0004 -0.0003 -0.0012 -0.0023 0.0003 619 75 15 POL 565 SLGIHLNPNK L K 28.0758 10 * 620 90 18 X 64 SSAGPCALR S R 26.0153 9 * 0.0080 0.1400 0.3300 0.1600 0.7500 621 95 19 NUC 170 STLPETTVVR T R 1069.21 10 * 0.0007 0.0600 0.0080 0.0240 0.0250 622 95 19 NUC 170 STLPETTVVRR T R 1083.01 11 0.0150 1.4000 0.1000 0.1600 0.3100 623 80 16 ENV 85 STNRQSGR T R 8 624 75 15 X 104 STTDLEAYFK T K 1.0584 10 * 0.0066 2.7000 625 85 17 POL 716 TAELLAACFAR A R 26.0544 11 0.0006 0.0023 0.0066 0.1600 0.0590 626 95 19 NUC 171 TLPETTVVR L R 1.0969 9 0.0008 0.0002 0.0009 0.0024 0.0180 627 95 19 NUC 171 TLPETTVVRR L R 1069.22 10 * 0.0007 0.0230 0.0006 0.0120 0.0440 628 95 19 NUC 171 TLPETTVVRRR L R 26.0545 11 * 0.0005 0.0160 0.0061 0.0710 0.6400 629 100 20 POL 150 TLWKAGILYK L K 1069.15 10 * 5.3000 0.3600 0.0051 0.0010

0.0130 630 100 20 POL 150 TLWKAGILYKR L R 26.0546 11 0.0082 0.0095 0.1000 0.1100 0.0640 631 95 19 POL 519 TSAICSVVR S R 5.0057 9 0.0005 0.0008 0.0600 0.0200 0.0820 632 95 19 POL 519 TSAICSVVRR S R 1142.08 10 * 0.0018 0.0006 0.0030 0.0066 0.0048 633 75 15 X 105 TTDLEAYFK T K 1.0215 9 * 0.0006 0.9200 0.0006 0.0012 0.0170 634 75 15 ENV 278 TTSTGPCK T K 8 635 80 16 NUC 175 TTVVRRRGR T R 1.0970 9 0.0008 0.0005 0.2500 0.1400 0.0095 636 80 16 NUC 176 TVVRRRGR V R 3.0324 8 0.0003 0.0001 637 80 16 NUC 176 TVVRRRGRSPR V R 28.0837 11 638 90 18 X 133 VLGGCRHK L K 26.0022 8 0.0150 0.0002 -0.0005 -0.0009 0.0001 639 80 16 ENV 177 VLQAGFFLLTR L R 11 640 90 18 NUC 120 VSFGVWIR S R 26.0023 8 * 0.0040 0.0290 0.0750 0.0270 0.0360 641 100 20 POL 48 VSIPWTHK S K 26.0024 8 * 0.0130 0.0170 0.0031 0.0013 0.0004 642 100 20 POL 358 VTGGVFLYDK T K 1069.17 10 * 0.0390 0.0920 0.0002 0.0006 0.0022 643 100 20 POL 378 VVDFSQFSR V R 1069.19 9 * 0.0015 0.0750 0.0013 0.0170 0.0330 644 80 16 NUC 177 VVRRRGRSPR V R 1.1074 10 0.0027 0.0001 645 80 16 NUC 177 VVRRRGRSPRR V R 28.0838 11 646 95 19 NUC 125 WIRTPPAYR I R 1.0968 9 0.0008 0.0005 647 90 18 POL 314 WLQFRNSK L K 26.0025 8 -0.0002 0.0005 0.0020 0.0052 0.0001 648 85 17 NUC 26 WLWGMDIDPYK L K 26.0547 11 0.0030 0.0013 -0.0003 0.0039 0.0490 649 100 20 POL 122 YLPLDKGIK L K 1.0173 9 0.0001 0.0001 0.0006 0.0006 0.0002 650 90 18 NUC 118 YLVSFGVWIR L R 1090.13 10 * 0.0005 0.0002 651 90 18 POL 538 YMDDVVLGAK M K 1090.15 10 * 0.0330 0.0043 0.0002 0.0006 0.0001 652 80 16 POL 493 YSHPIILGFR S R 10 653 80 16 POL 493 YSHPIILGFRK S K 11 654 118

TABLE-US-00010 TABLE IX HBV A24 SUPER MOTIF (With binding information) SEQ ID Conservancy Freq Protein Position Sequence String Peptide Filed A*2401 NO 95 19 POL 529 AFPHCLAF XFXXXXXF 655 95 19 POL 529 AFPHCLAFSY XFXXXXXXXY 656 95 19 POL 529 AFPHCLAFSYM XFXXXXXXXXM 657 95 19 X 62 AFSSAGPCAL XFXXXXXXXL 5.0118 0.0012 658 90 18 POL 535 AFSYMDDVVL XFXXXXXXXL 13.0130 0.0009 659 95 19 POL 655 AFTFSPTY XFXXXXXY 660 95 19 POL 655 AFTFSPTYKAF XFXXXXXXXXF 661 95 19 POL 521 AICSVVRRAF XIXXXXXXXF 662 90 18 NUC 58 AILCWGEL XIXXXXXL 663 90 18 NUC 58 AILCWGELM XIXXXXXXM 664 95 19 POL 642 ALMPLYACI XLXXXXXXI 3.0012 * 665 95 19 NUC 54 ALRQAILCW XLXXXXXXW 666 80 16 ENV 108 AMQWNSTTF XMXXXXXXF 667 95 19 POL 690 ATPTGWGL XTXXXXXL 668 75 15 POL 690 ATPTGWGLAI XTXXXXXXXI 669 95 19 POL 397 AVPNLQSL XVXXXXXL 670 95 19 POL 397 AVPNLQSLTNL XVXXXXXXXXL 671 100 20 NUC 131 AYRPPNAPI XYXXXXXXI 5.0082 * 0.0260 672 100 20 NUC 131 AYRPPNAPIL XYXXXXXXXL 2.0172 * 0.0220 673 75 15 POL 607 CFRKLPVNRPI XFXXXXXXXXI 674 100 20 ENV 312 CIPIPSSW XIXXXXXW 675 100 20 ENV 312 CIPIPSSWAF XIXXXXXXXF 676 85 17 NUC 23 CLGWLWGM XLXXXXXM 677 85 17 NUC 23 CLGWLWGMDI XLXXXXXXXI 2.0229 678 100 20 ENV 253 CLIFLLVL XLXXXXXL 17.0248 679 100 20 ENV 253 CLIFLLVLL XLXXXXXXL 1.0836 680 95 19 ENV 253 CLIFLLVLLDY XLXXXXXXXXY 26.0548 681 95 19 ENV 239 CLRRFIIF XLXXXXXF 682 95 19 ENV 239 CLRRFIIFL XLXXXXXXL 1.0829 683 75 15 ENV 239 CLRRFIIFLF XLXXXXXXXF 684 75 15 ENV 239 CLRRFIIFLFI XLXXXXXXXXI Chisari 685 4.055 100 20 ENV 310 CTCIPIPSSW XTXXXXXXXW 686 90 18 NUC 31 DIDPYKEF XIXXXXXF 687 85 17 NUC 29 DLLDTASAL XLXXXXXXL 1.0154 688 85 17 NUC 29 DLLDTASALY XLXXXXXXXY 1.0519 * 689 95 19 POL 40 DLNLGNLNVSI XLXXXXXXXXI 690 80 16 NUC 32 DTASALYREAL XTXXXXXXXXL 691 85 17 POL 618 DWKVCQRI XWXXXXXI 692 85 17 POL 618 DWKVCQRIVGL XWXXXXXXXXL 693 90 18 ENV 262 DYQGMLPVCPL XYXXXXXXXXL 3.0441 0.0002 694 80 16 X 122 ELGEEIRL XLXXXXXL 695 95 19 NUC 43 ELLSFLPSDF XLXXXXXXXF 696 95 19 NUC 43 ELLSFLPSDFF XLXXXXXXXXF 697 90 18 NUC 117 EYLVSFGVW XYXXXXXXW 26.0150 698 90 18 NUC 117 EYLVSFGVWI XYXXXXXXXI 13.0129 * 0.0340 699 100 20 ENV 382 FFCLWVYI XFXXXXXI 700 80 16 ENV 182 FFLLTRIL XFXXXXXL 701 80 16 ENV 182 FFLLTRILTI XFXXXXXXXI 702 85 17 ENV 13 FFPDHQLDPAF XFXXXXXXXXF 703 80 16 ENV 243 FIIFLFIL XIXXXXXL 17.0246 704 80 16 ENV 243 FIIFLFILL XIXXXXXXL 1.0830 705 80 16 ENV 243 FIIFLFILLL XIXXXXXXXL 1.0694 706 80 16 ENV 248 FILLLCLI XIXXXXXI Chisari 707 4.045 80 16 ENV 248 FILLLCLIF XIXXXXXXF 708 80 16 ENV 248 FILLLCLIFL XIXXXXXXXL 1.0895 * 709 80 16 ENV 248 FILLLCLIFLL XIXXXXXXXXL Chisari 710 4.049 80 16 ENV 246 FLFILLLCL XLXXXXXXL 1.0832 711 80 16 ENV 246 FLFILLLCLI XLXXXXXXXI 3.0206 * 712 80 16 ENV 246 FLFILLLCLIF XLXXXXXXXXF 713 75 15 ENV 171 FLGPLLVL XLXXXXXL 714 95 19 POL 513 FLLAQFTSAI XLXXXXXXXI 1147.13 * 715 95 19 POL 562 FLLSLGIHL XLXXXXXXL 1.0851 * 716 80 16 ENV 183 FLLTRILTI XLXXXXXXI 3.0005 * 717 95 19 ENV 256 FLLVLLDY XLXXXXXY 26.0027 718 95 19 ENV 256 FLLVLLDYQGM XLXXXXXXXXM 719 95 19 POL 656 FTFSPTYKAF XTXXXXXXXF 20.0262 720 95 19 POL 656 FTFSPTYKAFL XTXXXXXXXXL 721 95 19 POL 635 FTQCGYPAL XTXXXXXXL 5.0031 722 95 19 POL 635 FTQCGYPALM XTXXXXXXXM 5.0085 723 95 19 ENV 346 FVGLSPTVW XVXXXXXXW 724 95 19 ENV 346 FVGLSPTVWL XVXXXXXXXL 1.0931 725 90 18 X 132 FVLGGCRHKL XVXXXXXXXL 1.0588 726 95 19 ENV 342 FVQWFVGL XVXXXXXL 17.019 * 727 90 18 POL 766 FVYVPSAL XVXXXXXL 17.0260 * 728 95 19 POL 630 GFAAPFTQCGY XFXXXXXXXXY 729 80 16 ENV 181 GFFLLTRI XFXXXXXI 730 80 16 ENV 181 GFFLLTRIL XFXXXXXXL 731 80 16 ENV 181 GFFLLTRILTI XFXXXXXXXXI 732 95 19 ENV 12 GFFPDHQL XFXXXXXL 733 75 15 ENV 170 GFLGPLLVL XFXXXXXXL 734 80 16 POL 500 GFRKIPMGVGL XFXXXXXXXXL 735 95 19 POL 627 GLLGFAAPF XLXXXXXXF 20.0124 736 95 19 POL 509 GLSPFLLAQF XLXXXXXXXF 737 100 20 ENV 348 GLSPTVWL XLXXXXXL Chisari 738 4.012 75 15 ENV 348 GLSPTVWLSVI XLXXXXXXXXI Chisari 739 4.031 85 17 NUC 29 GMDIDPYKEF XMXXXXXXXF 26.0372 740 90 18 ENV 265 GMLPVCPL XMXXXXXL 741 90 18 POL 735 GTDNSVVL XTXXXXXL 742 75 15 ENV 13 GTNLSVPNPL XTXXXXXXXL 743 80 16 POL 763 GTSFVYVPSAL XTXXXXXXXXL 744 80 16 POL 507 GVGLSPFL XVXXXXXL 745 80 16 POL 507 GVGLSPFLL XVXXXXXXL 1.0850 746 95 19 NUC 128 GVWIRTPPAY XVXXXXXXXY 1.0525 747 85 17 NUC 25 GWLWGMDI XWXXXXXI 748 85 17 NUC 25 GWLWGMDIDPY XWXXXXXXXXY 749 85 17 ENV 65 GWSPQAQGI XWXXXXXXI 20.0134 0.0024 750 85 17 ENV 65 GWSPQAQGIL XWXXXXXXXL 20.0268 0.0003 751 95 19 POL 639 GYPALMPL XYXXXXXL 752 95 19 POL 639 GYPALMPLY XYXXXXXXY 2.0060 * 0.0490 753 95 19 ENV 234 GYRWMCLRRF XYXXXXXXXF 2.0171 * 0.0110 754 95 19 ENV 234 GYRWMCLRRFI XYXXXXXXXXI 755 85 17 POL 579 GYSLNFMGY XYXXXXXXY 2.0058 0.0002 756 75 15 POL 579 GYSLNFMGYVI XYXXXXXXXXI 757 80 16 POL 820 HFASPLHVAW XFXXXXXXXW 758 75 15 POL 7 HFRKLLLL XFXXXXXL 759 80 16 POL 435 HLLVGSSGL XLXXXXXXL 1.0187 760 75 15 POL 569 HLNPNKTKRW XLXXXXXXXW 761 80 16 POL 491 HLYSHPII XLXXXXXI 17.0256 762 80 16 POL 491 HLYSHPIIL XLXXXXXXL 1.0849 * 763 80 16 POL 491 HLYSHPIILGF XLXXXXXXXXF 764 85 17 POL 715 HTAELLAACF XTXXXXXXXF 765 100 20 NUC 52 HTALRQAI XTXXXXXI 766 95 19 NUC 52 HTALAQAIL XTXXXXXXL 5.0021 767 95 19 NUC 52 HTALRQAILCW XTXXXXXXXXW 768 100 20 POL 149 HTLWKAGI XTXXXXXI 769 100 20 POL 149 HTLWKAGIL XTXXXXXXL 5.0033 770 100 20 POL 149 HTLWKAGILY XTXXXXXXXY 1.0542 * 771 100 20 POL 146 HYLHTLWKAGI XYXXXXXXXXI 772 100 20 ENV 381 IFFCLWVY XFXXXXXY 773 100 20 ENV 381 IFFCLWVYI XFXXXXXXI 5.0058 0.0087 774

80 16 ENV 245 IFLFILLL XFXXXXXL 775 80 16 ENV 245 IFLFILLLCL XFXXXXXXXL 776 80 16 ENV 245 IFLFILLLCLI XFXXXXXXXXI 777 95 19 ENV 255 IFLLVLLDY XFXXXXXXY 778 80 16 ENV 244 IIFLFILL XIXXXXXL 17.0105 779 80 16 ENV 244 IIFLFILLL XIXXXXXXL 1.0831 780 80 16 ENV 244 IIFLFILLLCL XIXXXXXXXXL Chisari 781 4.052 80 16 POL 497 IILGFRKI XIXXXXXI 17.0124 * 782 80 16 POL 497 IILGFRKIPM XIXXXXXXXM 783 90 18 NUC 59 ILCWGELM XLXXXXXM 784 80 16 POL 498 ILGFRKIPM XLXXXXXXM 3.0016 785 100 20 ENV 249 ILLLCLIF XLXXXXXF 786 100 20 ENV 249 ILLLCLIFL XLXXXXXXL 1.0833 * 787 100 20 ENV 249 ILLLCLIFLL XLXXXXXXXL 1.0896 * 788 80 16 POL 760 ILRGTSFVY XLXXXXXXY 1.0205 * 789 95 19 ENV 188 ILTIPQSL XLXXXXXL 790 90 18 ENV 188 ILTIPQSLDSW XLXXXXXXXXW 791 90 18 POL 625 IVGLLGFAAPF XVXXXXXXXXF 792 85 17 ENV 358 IWMMWYWGPS XWXXXXXXXXL 1039.07 0.0004 793 95 19 POL 395 KFAVPNLQSL XFXXXXXXXL 5.0114 0.0020 794 80 16 POL 503 KIPMGVGL XIXXXXXL 795 80 16 POL 503 KIPMGVGLSPF XIXXXXXXXXF 796 85 17 NUC 21 KLCLGWLW XLXXXXXW 797 85 17 NUC 21 KLCLGWLWGM XLXXXXXXXM 3.0209 * 798 95 19 POL 489 KLHLYSHPI XLXXXXXXI 3.0009 * 799 80 16 POL 489 KLHLYSHPII XLXXXXXXXI 800 80 16 POL 489 KLHLYSHPIIL XLXXXXXXXXL 801 75 15 POL 108 KLIMPARF XLXXXXXF 802 75 15 POL 108 KLIMPARFY XLXXXXXXY 1.0171 803 80 16 POL 610 KLPVNRPI XLXXXXXI 804 80 16 POL 610 KLPVNRPIDW XLXXXXXXXW 805 95 19 POL 574 KTKRWGYSL XTXXXXXXL 5.0034 806 85 17 POL 574 KTKRWGYSLNF XTXXXXXXXXF 807 85 17 POL 620 KVCQRIVGL XVXXXXXXL 1.0198 808 85 17 POL 620 KVCQRIVGLL XVXXXXXXXL 1.0567 809 95 19 POL 55 KVGNFTGL XVXXXXXL 17.0116 810 95 19 POL 55 KVGNFTGLY XVXXXXXXY 1.0166 * 811 85 17 X 91 KVLHKRTL XVXXXXXL 812 85 17 X 91 KVLHKRTLGL XVXXXXXXXL 1.0800 813 100 20 POL 121 KYLPLDKGI XYXXXXXXI 5.0063 * 0.0028 814 85 17 POL 745 KYTSFPWL XYXXXXXL 17.0132 815 85 17 POL 745 KYTSFPWLL XYXXXXXXL 2.0061 * 3.6000 816 80 16 ENV 247 LFILLLCL XFXXXXXL 17.0247 817 80 16 ENV 247 LFILLLCLI XFXXXXXXI 818 80 16 ENV 247 LFILLLCLIF XFXXXXXXXF 819 80 16 ENV 247 LFILLLCLIFL XFXXXXXXXXL 820 100 20 ENV 254 LIFLLVLL XIXXXXXL Chisari 821 4.014 95 19 ENV 254 LIFLLVLLDY XIXXXXXXXY 1.0899 822 100 20 POL 109 LIMPARFY XIXXXXXY 26.0028 823 95 19 POL 514 LLAQFTSAI XLXXXXXXI 3.0010 * 824 100 20 ENV 251 LLCLIFLL XLXXXXXL Chisari 825 4.015 100 20 ENV 251 LLCLIFLLVL XLXXXXXXXL 1.0898 826 100 20 ENV 251 LLCLIFLLVLL XLXXXXXXXXL Chisari 827 4.016 85 17 NUC 30 LLDTASAL XLXXXXXL 828 83 17 NUC 30 LLDTASALY XLXXXXXXY 1.0155 * 829 95 19 ENV 260 LLDYQGML XLXXXXXL Chisari 830 4.021 80 16 POL 752 LLGCAANW XLXXXXXW 831 80 16 POL 752 LLGCAANWI XLXXXXXXI 3.0013 832 80 16 POL 752 LLGCAANWIL XLXXXXXXXL 1.0912 * 833 95 19 POL 628 LLGFAAPF XLXXXXXF 834 75 15 ENV 63 LLGWSPQAQGI XLXXXXXXXXI 835 100 20 ENV 250 LLLCLIFL XLXXXXXL Chisari 836 4.017 100 20 ENV 250 LLLCLIFLL XLXXXXXXL 1.0834 * 837 100 20 ENV 250 LLLCLIFLLVL XLXXXXXXXXL Chsari 838 4.018 100 20 ENV 378 LLPIFFCL XLXXXXXL 17.0112 839 100 20 ENV 378 LLPIFFCLW XLXXXXXXW 840 100 20 ENV 378 LLPIFFCLWVY XLXXXXXXXXY 26.0549 * 841 95 19 NUC 44 LLSFLPSDF XLXXXXXXF 842 95 19 NUC 44 LLSFLPSDFF XLXXXXXXXF 843 95 19 POL 563 LLSLGIHL XLXXXXXL 844 90 18 POL 407 LLSSNLSW XLXXXXXW 845 90 18 POL 407 LLSSNLSWL XLXXXXXXL 1.0184 * 846 90 18 POL 407 LLSSNLSWLSL XLXXXXXXXXL 847 80 16 ENV 184 LLTRILTI XLXXXXXI Chisari 848 4.053 80 16 POL 436 LLVGSSGL XLXXXXXL 849 95 19 ENV 257 LLVLLDYQGM XLXXXXXXXM 3.0207 850 95 19 ENV 257 LLVLLDYQGML XLXXXXXXXXL 851 95 19 ENV 175 LLVLQAGF XLXXXXXF 852 95 19 ENV 175 LLVLQAGFF XLXXXXXXF 20.0121 853 90 18 ENV 175 LLVLQAGFFL XLXXXXXXXL 1.0892 * 854 90 18 ENV 175 LLVLQAGFFLL XLXXXXXXXXL Chisari 855 4.028 100 20 ENV 338 LLVPFVQW XLXXXXXW 556 100 20 ENV 338 LLVPFVQWF XLXXXXXXF 857 90 18 NUC 100 LLWFHISCL XLXXXXXXL 1.0844 * 858 85 17 NUC 100 LLWFHISCLTF XLXXXXXXXXF 859 95 19 POL 643 LMPLYACI XMXXXXXI 17.0130 860 75 15 NUC 137 LTFGRETVL XTXXXXXXL 861 75 15 NUC 137 LTFGRETVLEY XTXXXXXXXXY 862 90 18 ENV 189 LTIPQSLDSW XTXXXXXXXW 863 90 18 ENV 189 LTIPQSLDSWW XTXXXXXXXXW 864 90 18 POL 404 LTNLLSSNL XTXXXXXXL 865 90 18 POL 404 LTNLLSSNLSW XTXXXXXXXXW 866 80 16 ENV 185 LTRILTIPQSL XTXXXXXXXXL 867 85 17 POL 99 LTVNEKRRL XTXXXXXXL 868 95 19 ENV 258 LVLLDYQGM XVXXXXXXM 3.0034 869 95 19 ENV 258 LVLLDYQGML XVXXXXXXXL 1.0515 870 95 19 ENV 176 LVLQAGFF XVXXXXXF 871 90 18 ENV 176 LVLQAGFFL XVXXXXXXL 1.0827 872 90 18 ENV 176 LVLQAGFFLL XVXXXXXXXL 1.0893 * 873 100 20 ENV 339 LVPFVQWF XVXXXXXF 874 95 19 ENV 339 LVPFVQWFVGL XVXXXXXXXXL 875 90 18 NUC 119 LVSFGVWI XVXXXXXI Chisari 876 4.078 100 20 POL 377 LVVDFSQF XVXXXXXF 877 90 18 NUC 101 LWFHISCL XWXXXXXL 878 85 17 NUC 101 LWFHISCLTF XWXXXXXXXF 26.0373 879 85 17 NUC 27 LWGMDIDPY XWXXXXXXY 880 100 20 POL 151 LWKAGILY XWXXXXXY 881 80 16 POL 492 LYSHPIIL XYXXXXXL 882 80 16 POL 492 LYSHPIILGF XYXXXXXXXF 2.0181 * 1.1000 883 85 17 ENV 360 MMWYWGPSL XMXXXXXXL 1.0839 * 0.0012 884 85 17 ENV 360 MMWYWGPSLY XMXXXXXXXY 1039.01 * 0.0001 885 85 17 ENV 361 MWYWGPSL XWXXXXXL 17.0249 886 85 17 ENV 361 MWYWGPSLY XWXXXXXXY 1039.02 0.0027 887 95 19 POL 561 NFLLSLGI XFXXXXXI 888 95 19 POL 561 NFLLSLGIHL XFXXXXXXXL 5.0115 0.0099 889 95 19 POL 42 NLGNLNVSI XLXXXXXXI 3.0008 890 96 19 POL 42 NLGNLNVSIPW XLXXXXXXXXW 891 90 18 POL 406 NLLSSNLSW XLXXXXXXW 892 90 18 POL 406 NLLSSNLSWL XLXXXXXXXL 1.0549 893 95 19 POL 45 NLNVSIPW XLXXXXXW 894

100 20 POL 400 NLQSLTNL XLXXXXXL 895 100 20 POL 400 NLQSLTNLL XLXXXXXXL 1.0183 896 75 15 ENV 15 NLSVPNPL XLXXXXXL 897 75 15 ENV 15 NLSVPNPLGF XLXXXXXXXF 898 80 16 POL 758 NWILRGTSF XWXXXXXXF 899 80 16 POL 758 NWILRGTSFVY XWXXXXXXXXY 900 95 19 POL 512 PFLLAQFTSAI XFXXXXXXXXI 901 95 19 POL 634 PFTQCGYPAL XFXXXXXXXL 5.0116 0.0002 902 95 19 POL 634 PFTQCGYPALM XFXXXXXXXXM 903 95 19 ENV 341 PFVQWFVGL XFXXXXXXL 5.0059 0.0003 904 85 17 POL 616 PIDWKVCQRI XIXXXXXXXI Chisari 905 4.091 100 20 ENV 380 PIFFCLWVY XIXXXXXXY 1.0843 906 100 20 ENV 380 PIFFCLWVYI XIXXXXXXXI 20.0258 907 85 17 POL 713 PIHTAELL XIXXXXXL 908 80 16 POL 496 PIILGFRKI XIXXXXXXI 927.48 909 80 16 POL 496 PIILGFRKIPM XIXXXXXXXXM 910 100 20 ENV 314 PIPSSWAF XIXXXXXF 911 100 20 POL 124 PLDKGIKPY XLXXXXXXY 1.0174 * 912 100 20 POL 124 PLDKGIKPYY XLXXXXXXXY 1.0541 * 913 95 19 POL 20 PLEEELPRL XLXXXXXXL 1.0163 914 95 19 ENV 10 PLGFFPDHQL XLXXXXXXXL 1.0511 915 100 20 POL 427 PLHPAAMPHL XLXXXXXXXL 1.0550 916 100 20 POL 427 PLHPAAMPHLL XLXXXXXXXXL 917 100 20 ENV 377 PLLPIFFCL XLXXXXXXL 1.0842 * 918 100 20 ENV 377 PLLPIFFCLW XLXXXXXXXW 919 95 19 ENV 174 PLLVLQAGF XLXXXXXXF 920 95 19 ENV 174 PLLVLQAGFF XLXXXXXXXF 921 90 18 ENV 174 PLLVLQAGFFL XLXXXXXXXXL Chisari 922 4.029 80 16 POL 711 PLPIHTAEL XLXXXXXXL 1.0201 923 80 16 POL 711 PLPIHTAELL XLXXXXXXXL 1.0569 924 75 15 POL 2 PLSYQHFRKL XLXXXXXXXL 1.0527 925 75 15 POL 2 PLSYQHFRKLL XLXXXXXXXXL 926 85 17 POL 98 PLTVNEKRRL XLXXXXXXXL 1.0536 927 80 16 POL 505 PMGVGLSPF XMXXXXXXF 928 80 16 POL 505 PMGVGLSPFL XMXXXXXXXL 1.0557 929 80 16 POL 505 PMGVGLSPFLL XMXXXXXXXXL 930 75 15 POL 692 PTGWGLAI XTXXXXXI 931 85 17 POL 797 PTTGRTSL XTXXXXXL 932 85 17 POL 797 PTTGRTSLY XTXXXXXXY 1.0208 * 933 80 16 NUC 15 PTVQASKL XTXXXXXL 934 80 16 NUC 15 PTVQASKLCL XTXXXXXXXL 935 75 15 ENV 351 PTVWLSVI XTXXXXXI 936 75 15 ENV 351 PTVWLSVIW XTXXXXXXW 937 75 15 ENV 351 PTVWLSVIWM XTXXXXXXXM 938 85 17 POL 612 PVNRPIDW XVXXXXXW 939 80 16 POL 750 PWLLGCAANW XWXXXXXXXW 940 80 16 POL 750 PWLLGCAANWI XWXXXXXXXXI 941 100 20 POL 51 PWTHKVGNF XWXXXXXXF 20.0138 * 0.0290 942 80 16 X 8 QLDPARDVL XLXXXXXXL 1.0210 943 80 16 X 8 QLDPARDVLCL XLXXXXXXXXL Chisari 944 4.073 90 18 NUC 99 QLLWFHISCL XLXXXXXXXL 1.0908 * 945 95 19 POL 685 QVFADATPTGW XVXXXXXXXXW 946 95 19 ENV 344 QWFVGLSPTVW XWXXXXXXXX 947 75 15 ENV 242 RFIIFLFI XFXXXXXI 17.0151 948 75 15 ENV 242 RFIIFLFIL XFXXXXXXL 949 75 15 ENV 242 RFIIFLFILL XFXXXXXXXL 950 75 15 ENV 242 RFIIFLFILLL XFXXXXXXXXL 951 100 20 ENV 332 RFSWLSLL XFXXXXXL 952 100 20 ENV 332 RFSWLSLLVPF XFXXXXXXXXF 953 80 16 ENV 187 RILTIPQSL XIXXXXXXL 1.0149 954 90 18 POL 624 RIVGLLGF XIXXXXXF 955 75 15 POL 106 RLKLIMPARF XLXXXXXXXF 956 75 15 POL 106 RLKLIMPARFY XLXXXXXXXXY 957 95 19 POL 376 RLVVDFSQF XLXXXXXXF 20.0122 958 90 18 POL 353 RTPARVTGGVF XTXXXXXXXXF 959 95 19 POL 36 RVAEDLNL XVXXXXXL 960 90 18 POL 36 RVAEDLNLGNL XVXXXXXXXXL 961 80 16 POL 818 RVHFASPL XVXXXXXL 962 100 20 POL 357 RVTGGVFL XVXXXXXL 963 85 17 POL 577 RWGYSLNF XWXXXXXF 964 85 17 POL 577 RWGYSLNFM XWXXXXXXM 265 85 17 POL 577 RWGYSLNFMGY XWXXXXXXXXY 966 95 19 ENV 236 RWMCLRRF XWXXXXXF 967 95 19 ENV 236 RWMCLRRFI XWXXXXXXI 20.0138 * 0.0710 968 95 19 ENV 236 RWMCLRRFII XWXXXXXXXI 20.0269 * 1.1000 969 95 19 ENV 236 RWMCLRRFIIF XWXXXXXXXXF 970 100 20 POL 167 SFCGSPYSW XFXXXXXXW 20.0139 * 0.0710 971 95 19 NUC 46 SFLPSDFF XFXXXXXF 972 80 16 POL 765 SFVYVPSAL XFXXXXXXL 973 100 20 POL 49 SIPWTHKVGNF XIXXXXXXXXF 974 95 19 ENV 194 SLDSWWTSL XLXXXXXXL 1.0150 975 95 19 ENV 194 SLDSWWTSLNF XLXXXXXXXXF 976 95 19 POL 416 SLDVSAAF XLXXXXXF 977 95 19 POL 416 SLDVSAAFY XLXXXXXXY 1.0186 * 978 100 20 ENV 337 SLLVPFVQW XLXXXXXXW 979 100 20 ENV 337 SLLVPFVQWF XLXXXXXXXF 980 75 15 POL 581 SLNFMGYVI XLXXXXXXI 3.0011 981 95 19 X 54 SLRGLPVCAF XLXXXXXXXF 20.0259 982 90 18 POL 403 SLTNLLSSNL XLXXXXXXXL 1.0548 983 75 15 X 104 STTDLEAY XTXXXXXY 984 75 15 X 104 STTDLEAYF XTXXXXXXF 985 75 15 ENV 17 SVPNPLGF SVXXXXXF 986 85 17 POL 548 SVQHLESL XVXXXXXL 987 80 16 ENV 330 SVRFSWLSL XVXXXXXXL 1.0153 988 80 16 ENV 330 SVRFSWLSLL XVXXXXXXXL 1.0517 989 90 18 POL 739 SVVLSRKY XVXXXXXY 26.0029 990 85 17 POL 739 SVVLSRKYTSF XVXXXXXXXXF 991 95 19 POL 524 SVVRRAFPHCL XVXXXXXXXXL 992 95 19 POL 413 SWLSLDVSAAF XWXXXXXXXXF 993 100 20 ENV 334 SWLSLLVPF XWXXXXXXF 20.0136 * 0.3900 994 95 19 POL 392 SWPKFAVPNL XWXXXXXXXL 20.0271 * 5.6000 995 100 20 ENV 197 SWWTSLNF XWXXXXXF 996 95 19 ENV 197 SWWTSLNFL XWXXXXXXL 20.0137 * 0.3800 997 90 18 POL 537 SYMDDVVL XYXXXXXL 998 75 15 POL 4 SYCHFRKL XYXXXXXL 999 75 15 POL 4 SYCHFRKLL XYXXXXXXL 2.0042 0.0051 1000 75 15 POL 4 SYCHFRKLLL XYXXXXXXXL 2.0173 * 0.0660 1001 75 15 POL 4 SYCHFRKLLLL XYXXXXXXXXL 1002 75 15 NUC 138 TFGRETVL XFXXXXXL 1003 75 15 NUC 138 TFGRETVLEY XFXXXXXXXY 1004 75 15 NUC 138 TFGRETVLEYL XFXXXXXXXXL 1005 95 19 POL 657 TFSPTYKAF XFXXXXXXF 5.0064 0.0060 1006 95 19 POL 657 TFSPTYKAFL XFXXXXXXXL 5.0117 0.0043 1007 90 18 ENV 190 TIPQSLDSW XIXXXXXXW 1008 90 18 ENV 190 TIPQSLDSWW XIXXXXXXXW 1009 100 20 POL 150 TLWKAGIL XLXXXXXL 1010 100 20 POL 150 TLWKAGILY XLXXXXXXY 1.0177 * 1011 75 15 X 105 TTDLEAYF XTXXXXXF 1012 85 17 POL 798 TTGRTSLY XTXXXXXY 26.0030 1013 85 17 POL 100 TVNEKRRL XVXXXXXL 1014 80 16 NUC 16 TVQASKLCL XVXXXXXXL 1.0365 1015 80 16 NUC 16 TVQASKLCLGW XVXXXXXXXXW 1016 75 15 ENV 352 TVWLSVIW XVXXXXXW 1017 75 15 ENV 352 TVWLSVIWM XVXXXXXXM 3.0035 1018

95 19 POL 686 VFADATPTGW XFXXXXXXXW 20.0272 * 0.0180 1019 75 15 X 131 VFVLGGCRHKL XFXXXXXXXXL 1020 85 17 POL 543 VLGAKSVQHL XLXXXXXXXL 1.0560 1021 90 18 X 133 VLGGCRKHL XLXXXXXXL 1.0220 1022 85 17 X 92 VLHKRTLGL XLXXXXXXL 1.0391 1023 95 19 ENV 259 VLLDYQGM XLXXXXXM 17.0107 1024 95 19 ENV 259 VLLDYQGML XLXXXXXXL 1.0151 * 1025 95 19 ENV 177 VLQAGFFL XLXXXXXL Chisari 1026 4.027 95 19 ENV 177 VLQAGFFLL XLXXXXXXL 1.0828 * 1027 85 17 POL 741 VLSRKYTSF XLXXXXXXF 1028 85 17 POL 741 VLSRKYTSFPW XLXXXXXXXXW 1029 80 16 POL 542 VVLGAKSVQHL XVXXXXXXXXL 1030 85 17 POL 740 VVLSRKYTSF XVXXXXXXXF 20.9261 1031 95 19 POL 525 VVRRAFPHCL XVXXXXXXXL 1.0558 1032 95 19 NUC 124 VWIRTPPAY XWXXXXXXY 1033 75 15 ENV 353 VWLSVIWM XWXXXXXM 1034 90 18 NUC 102 WFHISCLTF XFXXXXXXF 13.0073 * 0.0300 1035 95 19 ENV 345 WFVGLSPTVW XFXXXXXXXW 20.0270 * 0.0120 1036 95 19 ENV 345 WFVGLSPTVWL XFXXXXXXXXL 1037 80 16 POL 759 WILRGTSF XIXXXXXF 1038 80 16 POL 759 WILRGTSFVY XIXXXXXXXY 1.0572 1039 95 19 NUC 125 WIRTPPAY XIXXXXXY 26.0031 1040 80 16 POL 751 WLLGCAANW XLXXXXXXW 1041 80 16 POL 751 WLLGCAANWI XLXXXXXXXI Chisari 1042 4.104 80 16 POL 751 WLLGCAANWIL XLXXXXXXXXL 1043 95 19 POL 414 WLSLDVSAAF XLXXXXXXXF 1044 95 19 POL 414 WLSLDVSAAFY XLXXXXXXXXY 26.0551 1045 100 20 ENV 335 WLSLLVPF XLXXXXXF 1046 100 20 ENV 335 WLSLLVPFVQW XLXXXXXXXXW 1047 85 17 NUC 26 WLWGMDIDPY XLXXXXXXXY 1.0774 * 1048 95 19 ENV 237 WMCLRRFI XMXXXXXI 1049 95 19 ENV 237 WMCLRRFII XMXXXXXXI 3.0031 * 0.0230 1050 95 19 ENV 237 WMCLRRFIIF XMXXXXXXXF 20.0266 0.0013 1051 95 19 ENV 237 WMCLRRFIIFL XMXXXXXXXXL Chisari 1052 4.024 85 17 ENV 359 WMMWYWGPSL XMXXXXXXXL 1.0901 * 0.0005 1053 85 17 ENV 359 WMMWYWGPSL XMXXXXXXXXY 26.0552 * 1054 100 20 POL 52 WTHKVGNF XTXXXXXF 1055 95 19 POL 52 WTHKVGNFTGL XTXXXXXXXXL 1056 95 19 ENV 198 WWTSLNFL XWXXXXXL 1057 85 17 ENV 362 WYWGPSLY XYXXXXXY 3.0362 0.0001 1058 100 20 POL 147 YLHTLWKAGI XLXXXXXXXI 7.0066 * 1059 100 20 POL 147 YLHTLWKAGIL XLXXXXXXXXL 1060 100 20 POL 122 YLPLDKGI XLXXXXXI 1061 100 20 POL 122 YLPLDKGIKPY XLXXXXXXXXY 26.0553 1062 90 18 NUC 118 YLVSFGVW XLXXXXXW 1063 90 18 NUC 118 YLVSFGVWI XLXXXXXXL 3.0007 * 1064 85 17 POL 746 YTSFPWLL XTXXXXXL 1065 411

TABLE-US-00011 TABLE X HBV B07 SUPER MOTIF (With binding information) C- Conservancy Frequency Protein Position Sequence P2 term Peptide AA Filed B*0702 B*3501 75 15 X 146 APCNFFTSA P A 9 95 19 POL 633 APFTQOCY P Y 19.0013 8 0.0001 0.0012 95 19 POL 633 APFTQCGYPA P A 16.0180 10 * 0.0029 0.0001 95 19 POL 633 APFTQCGYPAL P L 26.0554 11 * 0.2300 0.0010 100 20 ENV 232 CPGYRWMCL P L 1308.21 9 80 16 NUC 14 CPTVQASKL P L 9 80 16 NUC 14 CPTVQASKLCL P L 11 80 16 X 10 DPARDVLCL P L 9 80 16 ENV 122 DPRVRGLY P Y 8 90 18 POL 778 DPSRGRLGL P L 1147.01 9 * 0.0120 0.0001 90 18 NUC 33 DPYKEFGA P A 19.0008 8 0.0001 0.0001 75 15 ENV 130 FPAGGSSSGTV P V 11 90 18 ENV 14 FPDHQLDPA P A 1308.23 9 * 85 17 ENV 14 FPDHQLDPAF P F 20.0274 10 0.0002 0.0016 95 19 POL 530 FPHCLAFSY P Y 1145.08 9 * 0.0001 0.5250 95 19 POL 530 FPHCLAFSYM P M 1147.05 10 * 0.0990 0.2200 75 15 POL 749 FPWLLGCA P A 8 75 15 POL 749 FPVVLLGCAA P A 9 75 15 POL 749 FPWLLGCAANW P W 11 90 18 X 67 GPCALRFTSA P A 16.0182 10 * 0.0900 0.0001 95 19 POL 19 GPLEEELPRL P L 15.0208 10 0.0001 0.0001 90 18 POL 19 GPLEEELPRLA P A 26.0555 11 -0.0002 0.0001 95 19 ENV 173 GPLLVLQA P A 19.0003 8 * 0.0003 0.0001 95 19 ENV 173 GPLLVLQAGF P F 15.0212 10 0.0001 0.0001 95 19 ENV 173 GPLLVLQAGFF P F 26.0556 11 0.0011 0.0001 85 17 POL 97 GPLTVNEKRRL P L 26.0557 11 0.0031 0.0001 100 20 POL 429 HPAAMPHL P L 19.0011 8 * 0.0650 0.0004 100 20 POL 429 HPAAMPHLL P L 1147.02 9 * 0.0980 0.0270 85 17 POL 429 HPAAMPHLLV P V 20.0273 10 * 0.0160 0.0020 80 16 POL 495 HPIILGFRKI P I 10 100 20 ENV 313 IPIPSSWA P A 19.0005 8 * 0.0004 0.0004 100 20 ENV 313 IPIPSSWAF P F 1145.04 9 * 0.1300 2.7679 80 16 ENV 313 IPIPSSWAFA P A 16.0177 10 * 0.0013 0.0024 80 16 POL 504 IPMGVGLSPF P F 10 80 16 POL 504 IPMGVGLSPFL P L 11 90 18 ENV 191 IPQSLDSW P W F126.65 8 90 18 ENV 191 IPQSLDSWW P W F126.60 9 * 80 16 ENV 315 IPSSWAFA P A 8 100 20 POL 50 IPWTHKVGNF P F 15.0209 10 0.0013 0.0001 100 20 ENV 379 LPIFFCLW P W 19.0007 8 * 0.0001 0.0001 100 20 ENV 379 LPIFFCLWV P V 1308.22 9 * 100 20 ENV 379 LPIFFCLWVY P Y 15.0215 10 0.0002 0.0079 100 20 ENV 379 LPIFFCLWVYI P I 26.0558 11 0.0002 0.0001 85 17 POL 712 LPIHTAEL P L 17.0259 8 85 17 POL 712 LPIHTAELL P L 20.0140 9 * 0.0040 0.0630 85 17 POL 712 LPIHTAELLA P A 16.0181 10 * 0.0018 0.0011 85 17 POL 712 LPIHTAELLAA P A 26.0559 11 0.0090 0.0027 80 16 X 89 LPKVLHKRTL P L 10 100 20 POL 123 LPLDKGIKPY P Y 15.0210 10 * 0.0001 0.0290 100 20 POL 123 LPLDKGIKPYY P Y 26.0560 11 -0.0002 0.0009 95 19 X 58 LPVCAFSSA P A 1147.06 9 * 0.0480 0.0710 80 16 POL 611 LPVNRPIDW P W 9 80 16 POL 611 LPVNRPIDWKV P V 11 80 16 POL 433 MPHLLVGSSGL P L 11 100 20 POL 1 MPLSYQHF P F 19.0010 8 * 0.0001 0.0097 75 15 POL 1 MPLSYQHFRKL P L 11 90 18 POL 774 NPADDPSRGRL P L 26.0561 11 * 0.0120 0.0001 95 19 ENV 9 NPLGFFPDHQL P L 26.0562 11 0.0012 0.0021 75 15 POL 571 NPNKTKRW P W 8 75 15 POL 571 NPNKTKRWGY P Y 10 95 19 NUC 129 PPAYRPPNA P A 16.0007 9 0.0001 0.0001 95 19 NUC 129 PPAYRPPNAPI P I 26.0563 11 85 17 ENV 58 PPHGGLLGW P W 20.0141 9 0.0001 0.0002 100 20 NUC 134 PPNAPILSTL P L 15.0211 10 0.0001 0.0001 80 16 POL 615 RPIDWKVCQRI P I 11 100 20 NUC 133 RPPNAPIL P L 19.0009 8 * 0.0078 0.0001 100 20 NUC 133 RPPNAPILSTL P L 26.0564 11 * 0.1300 0.0001 100 20 NUC 44 SPEHCSPHHTA P A 26.0565 11 -0.0002 0.0001 95 19 POL 511 SPFLLAQF P F 19.0012 8 * 0.5500 0.0009 95 19 POL 511 SPFLLAQFTSA P A 26.0566 11 * 0.0820 0.0001 100 20 NUC 49 SPHHTALRQA P A 16.0178 10 0.0012 0.0001 100 20 NUC 49 SPHHTALRQAI P I 26.0567 11 * 0.5800 0.0001 85 17 ENV 67 SPQAQGIL P L 8 85 17 POL 808 SPSVPSHL P L 8 75 15 ENV 350 SPTVWLSV P V 8 75 15 ENV 350 SPTVWLSVI P I 1308.16 9 75 15 ENV 350 SPTVWLSVIW P W 1308.17 10 75 15 ENV 350 SPTVWLSVIWM P M 11 95 19 POL 659 SPTYKAFL P L 19.0015 8 * 0.3900 0.0001 90 18 POL 354 TPARVTGGV P V 1147.07 9 * 0.0078 0.0001 90 18 POL 354 TPARVTGGVF P F 1147.04 10 * 0.3200 0.1000 90 18 POL 354 TPARVTGGVFL P L 26.0568 11 * 0.0950 0.0001 95 19 NUC 128 TPPAYRPPNA P A 16.0179 10 * 0.0001 0.0001 75 15 ENV 57 TPPHGGLL P L 8 75 15 ENV 57 TPPHGGLLGW P W 1308.04 10 80 16 POL 691 TPTGWGLA P A 8 75 15 POL 691 TPTGWGLAI P I 9 95 19 ENV 340 VPFVQWFV P V 19.0006 8 * 0.0010 0.0001 95 19 ENV 340 VPFVQNFVGL P L 15.0213 10 0.0011 0.0001 95 19 POL 398 VPNLQSLTNL P L 15.0216 10 0.0006 0.0001 95 19 POL 396 VPNLQSLTNLL P L 26.0569 11 0.0004 0.0001 90 18 POL 769 VPSALNPA P A 19.0016 8 * 0.0011 0.0001 95 19 POL 393 WPKFAVPNL P L 15.0035 9 0.0054 0.0002 95 19 POL 640 YPALMPLY P Y 19.0014 8 * 0.0004 0.2600 95 19 POL 640 YPALMPLYA P A 1147.08 9 * 0.0180 0.0480 95 19 POL 640 YPALMPLYACI R I 26.0570 11 0.0040 0.0001 SEQ ID Conservancy Frequency Protein Position Sequence B*5101 B*5301 B*5401 NO: 75 15 X 146 APCNFFTSA 1066 95 19 POL 633 APFTQOCY 0.0019 0.0002 0.0002 1067 95 19 POL 633 APFTQCGYPA 0.0002 1.4000 1068 95 19 POL 633 APFTQCGYPAL 0.0004 -0.0003 0.0093 1069 100 20 ENV 232 CPGYRWMCL 1070 80 16 NUC 14 CPTVQASKL 1071 80 16 NUC 14 CPTVQASKLCL 1072 80 16 X 10 DPARDVLCL 1073 80 16 ENV 122 DPRVRGLY 1074 90 18 POL 778 DPSRGRLGL 0.0001 0.0001 0.0001 1075 90 18 NUC 33 DPYKEFGA 0.0019 0.0002 0.0019 1076 75 15 ENV 130 FPAGGSSSGTV 1077 90 18 ENV 14 FPDHQLDPA 1078 85 17 ENV 14 FPDHQLDPAF 0.0003 0.0011 0.0021 1079 95 19 POL 530 FPHCLAFSY 0.0665 0.5400 0.0199 1080 95 19 POL 530 FPHCLAFSYM 0.0900 0.0790 0.0480 1081 75 15 POL 749 FPWLLGCA 1082 75 15 POL 749 FPVVLLGCAA 1083 75 15 POL 749 FPWLLGCAANW 1084 90 18 X 67 GPCALRFTSA 0.0001 0.0002 0.0035 1085 95 19 POL 19 GPLEEELPRL 0.0002 0.0001 0.0002 1086 90 18 POL 19 GPLEEELPRLA 0.0001 -0.0003 0.0001 1087 95 19 ENV 173 GPLLVLQA 0.0110 0.0002 0.0065 1088

95 19 ENV 173 GPLLVLQAGF 0.0002 0.0001 0.0002 1089 95 19 ENV 173 GPLLVLQAGFF 0.0001 0.0008 0.0009 1090 85 17 POL 97 GPLTVNEKRRL 0.0001 -0.0003 0.0001 1091 100 20 POL 429 HPAAMPHL 0.3100 0.0037 0.0160 1092 100 20 POL 429 HPAAMPHLL 0.0110 0.0500 0.0120 1093 85 17 POL 429 HPAAMPHLLV 0.0078 0.0140 0.0170 1094 80 16 POL 495 HPIILGFRKI 1095 100 20 ENV 313 IPIPSSWA 0.0019 0.0002 0.0600 1096 100 20 ENV 313 IPIPSSWAF 2.3500 0.7450 0.0034 1097 80 16 ENV 313 IPIPSSWAFA 0.0014 0.4500 1098 80 16 POL 504 IPMGVGLSPF 1099 80 16 POL 504 IPMGVGLSPFL 1100 90 18 ENV 191 IPQSLDSW 1101 90 18 ENV 191 IPQSLDSWW 1102 80 16 ENV 315 IPSSWAFA 1103 100 20 POL 50 IPWTHKVGNF 0.0007 0.0001 0.0002 1104 100 20 ENV 379 LPIFFCLW 0.0360 0.1400 0.0035 1105 100 20 ENV 379 LPIFFCLWV 1106 100 20 ENV 379 LPIFFCLWVY 0.0002 0.0006 0.0002 1107 100 20 ENV 379 LPIFFCLWVYI 0.0043 0.0139 0.0021 1108 85 17 POL 712 LPIHTAEL 1109 85 17 POL 712 LPIHTAELL 0.0052 0.3100 0.0005 1110 85 17 POL 712 LPIHTAELLA 0.0016 0.3300 1111 85 17 POL 712 LPIHTAELLAA -0.0003 0.0120 2.7500 1112 80 16 X 89 LPKVLHKRTL 1113 100 20 POL 123 LPLDKGIKPY 0.0002 0.0003 0.0002 1114 100 20 POL 123 LPLDKGIKPYY 0.0001 0.0007 0.0001 1115 95 19 X 58 LPVCAFSSA 0.0110 0.0009 19.0000 1116 80 16 POL 611 LPVNRPIDW 1117 80 16 POL 611 LPVNRPIDWKV 1118 80 16 POL 433 MPHLLVGSSGL 1119 100 20 POL 1 MPLSYQHF 0.0120 0.0370 0.0190 1120 75 15 POL 1 MPLSYQHFRKL 1121 90 18 POL 774 NPADDPSRGRL 0.0001 -0.0003 0.0001 1122 95 19 ENV 9 NPLGFFPDHQL 0.0001 0.0028 0.0001 1123 75 15 POL 571 NPNKTKRW 1124 75 15 POL 571 NPNKTKRWGY 1125 95 19 NUC 129 PPAYRPPNA 0.0001 0.0002 0.0003 1126 95 19 NUC 129 PPAYRPPNAPI 0.0001 -0.0003 0.0001 1127 85 17 ENV 58 PPHGGLLGW 0.0001 0.0003 0.0002 1128 100 20 NUC 134 PPNAPILSTL 0.0035 0.0001 0.0002 1129 80 16 POL 615 RPIDWKVCQRI 1130 100 20 NUC 133 RPPNAPIL 0.0280 0.0002 0.0002 1131 100 20 NUC 133 RPPNAPILSTL 0.0018 -0.0003 0.0001 1132 100 20 NUC 44 SPEHCSPHHTA 0.0001 -0.0003 0.0011 1133 95 19 POL 511 SPFLLAQF 0.0180 0.0009 0.0093 1134 95 19 POL 511 SPFLLAQFTSA 0.0001 -0.0003 12.0500 1135 100 20 NUC 49 SPHHTALRQA 0.0002 0.0035 1136 100 20 NUC 49 SPHHTALRQAI 0.0004 0.0005 0.0002 1137 85 17 ENV 67 SPQAQGIL 1138 85 17 POL 808 SPSVPSHL 1139 75 15 ENV 350 SPTVWLSV 1140 75 15 ENV 350 SPTVWLSVI 1141 75 15 ENV 350 SPTVWLSVIW 1142 75 15 ENV 350 SPTVWLSVIWM 1143 95 19 POL 659 SPTYKAFL 0.0019 0.0002 0.0002 1144 90 18 POL 354 TPARVTGGV 0.0013 0.0001 0.0015 1145 90 18 POL 354 TPARVTGGVF 0.0001 0.0099 0.0006 1146 90 18 POL 354 TPARVTGGVFL 0.0001 0.0005 0.0005 1147 95 19 NUC 128 TPPAYRPPNA 0.0002 0.0100 1148 75 15 ENV 57 TPPHGGLL 1149 75 15 ENV 57 TPPHGGLLGW 1150 80 16 POL 691 TPTGWGLA 1151 75 15 POL 691 TPTGWGLAI 1152 95 19 ENV 340 VPFVQWFV 19.0000 0.0002 0.1100 1153 95 19 ENV 340 VPFVQNFVGL 0.0100 0.0001 0.0025 1154 95 19 POL 398 VPNLQSLTNL 0.0004 0.0001 0.0002 1155 95 19 POL 396 VPNLQSLTNLL 0.0001 -0.0003 0.0002 1156 90 18 POL 769 VPSALNPA 0.0070 0.0002 1.0000 1157 95 19 POL 393 WPKFAVPNL 0.0015 0.0001 0.0015 1158 95 19 POL 640 YPALMPLY 0.4100 0.0450 0.0056 1159 95 19 POL 640 YPALMPLYA 0.0340 0.0140 16.0000 1160 95 19 POL 640 YPALMPLYACI 0.0470 0.0320 0.0700 1161 96

TABLE-US-00012 TABLE XI HBV B27 SUPER MOTIF SEQ ID Source Conservancy Freq Protein Position Sequence String Supermotif Peptide Filed NO: HBV 95 19 X 51 AHLSLRGL XHXXXXXL B27s 1162 HBV 85 17 POL 546 AKSVCHLESL XKXXXXXXXL B27s 1163 HBV 90 18 POL 356 ARVTGGVF XRXXXXXF B27s 1164 HBV 90 18 POL 356 ARVTGGVFL XXXXXXXL B27s 1165 HBV 95 19 X 48 DHGAHLSL XHXXXXXL B27s 1166 HBV 95 19 X 48 DHGAHLSLRGL XHXXXXXXXXL B27s 1167 HBV 90 18 ENV 16 DHQLDPAF XHXXXXXF B27s 1168 HBV 100 20 POL 126 DKGIKPYY XKXXXXXY B27s 1169 HBV 100 20 NUC 46 EHCSPHHTAL XHXXXXXXXL B27s 1170 HBV 90 16 NUC 103 FHISCLTF XHXXXXXF B27s 1171 HBV 80 16 POL 501 FRKIPMGVGL XRXXXXXXXL B27s 1172 HBV 80 16 POL 608 FRKLOVNRPI XRXXXXXXXI B27s 1173 HBV 75 15 NUC 140 GRETVLEY XRXXXXXY B27s 1174 HBV 75 15 NUC 140 GRETVLEYL XRXXXXXXL B27s 1175 HBV 100 20 NUC 51 HHTALRQAI XHXXXXXXI B27s 1176 HBV 95 19 NUC 51 HHTALRQAIL XHXXXXXXXL B27s 1177 HBV 95 19 POL 54 HKVGNFTGL XKXXXXXXL B27s 17.0358 1178 HBV 95 19 POL 54 HKVGNFTGLY XKXXXXXXXY B27s 1179 HBV 75 15 POL 568 IHLNPNKTKRW XHXXXXXXXXW B27s 1180 HBV 85 17 POL 714 IHTAELLAACF XHXXXXXXXXF B27s 1181 HBV 85 17 POL 576 KRWGYSLNF XRXXXXXXF B27s 1182 HBV 85 17 POL 576 KRWGYSLNFM XRXXXXXXXM B27s 1183 HBV 90 18 X 93 LHKRTLGL XHXXXXXL B27s 1184 HBV 95 19 POL 490 LHLYSHPI XHXXXXXI B27s 1185 HBV 80 16 POL 490 LHLYSHPII XHXXXXXXI B27s 1186 HBV 80 16 POL 490 LHLYSHPIIL XHXXXXXXXL B27s 1187 HBV 100 20 POL 428 LHPAAMPHL XHXXXXXXL B27s 1188 HBV 100 20 POL 428 LHPAAMPHLL XHXXXXXXXL B27s 1189 HBV 100 20 POL 148 LHTLWKAGI XHXXXXXXI B27s 1190 HBV 100 20 POL 148 LHTLWKAGIL XHXXXXXXXL B27s 1191 HBV 100 20 POL 148 LHTLWKAGILY XHXXXXXXXXY B27s 1192 HBV 75 15 POL 107 LKLIMPARF XKXXXXXXF B27s 1193 HBV 75 15 POL 107 LKLIMPARFY XKXXXXXXXY B27s 1194 HBV 95 19 POL 55 LRGLPVCAF XRXXXXXXF B27s 1195 HBV 80 16 NUC 761 LRGTSFVY XRXXXXXY B27s 1196 HBV 95 19 NUC 55 LRQAILCW XRXXXXXW B27s 1197 HBV 90 18 ENV 55 LRQAILCWGEL XRXXXXXXXXL B27s 1198 HBV 95 19 ENV 240 LRRFIIFL XRXXXXXL B27s 1199 HBV 75 15 ENV 240 LRRFIIFLF XRXXXXXXF B27s 1200 HBV 75 15 ENV 240 LRRFIIFLFI XRXXXXXXXI B27s 1201 HBV 75 15 POL 240 LRRFIIFLFIL XRXXXXXXXXL B27s 1202 HBV 75 15 POL 573 NKTKRWGY XKXXXXXY B27s 1203 HBV 75 15 POL 573 NKTKRWGYSL XKXXXXXXXL B27s 1204 HBV 85 17 POL 34 NRRVAEDL XRXXXXXL B27s 1206 HBV 85 17 POL 34 NRRVAEDLNL XRXXXXXXXL B27s 1206 HBV 95 19 POL 531 PHCLAFSY XHXXXXXY B27s 1207 HBV 95 19 POL 531 PHCLAFSYM XHXXXXXXM B27s 1208 HBV 85 17 ENV 59 PHGGLLGW XHXXXXXW B27s 1209 HBV 100 20 NUC 50 PHHTALRQAI XHXXXXXXXI B27s 1210 HBV 95 19 NUC 50 PHHTALRQAIL XHXXXXXXXXL B27s 1211 HBV 80 16 POL 434 PHLLVGSSGL XHXXXXXXXL B27s 1212 HBV 95 19 POL 394 PKFAVPNL XKXXXXX B27s 1213 HBV 95 19 POL 394 PKFAVPNLQSL XKXXXXXXXXL B27s 1214 HBV 85 17 X 90 PKVLHKRTL XKXXXXXXL B27s 1215 HBV 85 17 X 90 PKVLHKRTLGL XKXXXXXXXXL B27s 1216 HBV 75 15 POL 6 QHFRKLLL XHXXXXXL B27s 1217 HBV 75 15 POL 6 QHFRKLLLL XHXXXXXXL B27s 1218 HBV 90 18 POL 623 QRIVGLLGF XRXXXXXXF B27s 1219 HBV 100 20 POL 145 RHYLHTLW XHXXXXXW B27s 1220 HBV 80 16 POL 502 RKIPMGVGL XKXXXXXXL B27s 1221 HBV 80 16 POL 609 RKLPVNRPI XKXXXXXXI B27s 1222 HBV 80 16 POL 609 RKLPVNRPIDW XKXXXXXXXXW B27s 1223 HBV 85 17 POL 744 RKYTSFPW XKXXXXXW B27s 1224 HBV 85 17 POL 744 RKYTSFPWL XKXXXXXXL B27s 1225 HBV 85 17 POL 744 RKYTSFPWLL XKXXXXXXXL B27s 1226 HBV 95 19 POL 527 RRAFPHCL XRXXXXXL B27s 1227 HBV 95 19 POL 527 RRAFPHCLAF XRXXXXXXXF B27s 1228 HBV 75 15 ENV 241 RRFIIFLF XRXXXXXF B27s 1229 HBV 75 15 ENV 241 RRFIIFLFI XRXXXXXXI B27s 1230 HBV 75 15 ENV 241 RRFIIFLFIL XRXXXXXXXL B27s 1231 HBV 75 15 ENV 241 RRFIIFLFILL XRXXXXXXXXL B27s 1232 HBV 75 15 POL 105 RRLKLIMPARF XRXXXXXXXXF B27s 1233 HBV 90 18 POL 35 RRVAEDLNL XRXXXXXXL B27s 1234 HBV 80 16 POL 494 SHPIILGF XHXXXXXF B27s 1235 HBV 80 16 POL 494 SHPIILGFRKI XHXXXXXXXXI B27s 1236 HBV 90 18 NUC 20 SKLCLGWL XKXXXXXL B27s 1237 HBV 85 17 NUC 20 SKLCLGWLW XKXXXXXXW B27s 1238 HBV 85 17 NUC 20 SKLCLGWLWGM XKXXXXXXXXM B27s 1239 HBV 85 17 POL 743 SRKYTSFPW XRXXXXXXW B27s 1240 HBV 85 17 POL 743 SRKYTSFPWL XRXXXXXXXL B27s 1241 HBV 85 17 POL 743 SPKYTSFPWLL XRXXXXXXXXL B27s 1242 HBV 95 19 POL 375 SPLVVDFSQF XRXXXXXXXF B27s 1243 HBV 80 16 POL 472 SRNLYVSL XRXXXXXL B27s 17.0123 1244 HBV 95 19 POL 53 THKVGNFTGL XHXXXXXXXL B27s 1245 HBV 95 19 POL 53 THKVGNFTGLY XHXXXXXXXXY B27s 1246 HBV 95 19 POL 575 TKRWGYSL XKXXXXXL B27s 1247 HBV 85 17 POL 575 TKRWGYSLNF XKXXXXXXXF B27s 1248 HBV 85 17 POL 575 TKRWGYSLNFM XKXXXXXXXXM B27s 1249 HBV 100 20 POL 120 TKYLPLDKGI XKXXXXXXXI B27s 1250 HBV 100 20 POL 144 TRHYLHTL XRXXXXXL B27s 1251 HBV 100 20 POL 144 TRHYLHTLW XRXXXXXXW B27s 1252 HBV 80 16 ENV 186 TRILTIPQSL XRXXXXXXXL B27s 1253 HBV 80 16 POL 819 VHFASPHVAW XHXXXXXXXXW B27s 1254 HBV 80 16 ENV 331 VRFSWLSL XRXXXXXL B27s 1255 HBV 80 16 ENV 331 VRFSWLSLL XRXXXXXXL B27s 1256 HBV 95 19 POL 526 VRRAFPHCL XRXXXXXXL B27s 1257 HBV 95 19 POL 526 VRRAFPHCLAF XRXXXXXXXXF B27s 1258 HBV 85 17 POL 619 WKVCQRIVGL XKXXXXXXXL B27s 1259 HBV 85 17 POL 619 WKVCQRIVGLL XKXXXXXXXXL B27s 1260 HBV 100 20 NUC 132 YRPPNAPI XRXXXXX B27s 1261 HBV 100 20 NUC 132 YRPPNAPIL XRXXXXXX B27s 17.0356 1262 HBV 95 19 ENV 235 YRWMCLRRF XRXXXXXXF B27s 1263 HBV 95 19 ENV 235 YRWMCLRRFI XRXXXXXXXI B27s 1264 HBV 95 19 ENV 235 YRWMCLRRFII XRXXXXXXXXI B27s 1265 104

TABLE-US-00013 TABLE XII HBV B44 SUPER MOTIF SEQ ID Source Conservancy Freq Protein Position Sequence String Supermotif Peptide Filed NO: HBV 95 19 POL 688 ADATPTGW XDXXXXXW B44 1266 HBV 95 19 POL 688 ADATPTGWGL XDXXXXXXXL B44 1267 HBV 80 16 POL 688 ADATPTGWGL XDXXXXXXXXA B44 1268 HBV 90 18 POL 776 ADDPSRGRL XDXXXXXXL B44 1269 HBV 90 18 POL 776 ADDPSRGRLGL XDXXXXXXXXL B44 1270 HBV 95 19 POL 38 AEDUNLGNL XEXXXXXXL B44 17.0357 1271 HBV 95 19 POL 38 AEDUNLGNUNV XEXXXXXXXXV B44 1272 HBV 85 17 POL 717 AELLAACF XEXXXXXF B44 1273 HBV 85 17 POL 717 AELLAACFA XEXXXXXXA B44 1274 HBV 90 18 POL 777 DDPSRGRL XDXXXXXL B44 17.0010 1278 HBV 90 18 POL 777 DDPSRGRGL XDXXXXXXXL B44 17.0418 1276 HBV 90 18 POL 540 DDVVLGAKSV XDXXXXXXXV B44 1277 HBV 75 15 POL 16 DEAGPLEEEL XEXXXXXXXL B44 1278 HBV 95 19 POL 39 EDUNLGNL XDXXXXXL B44 1279 HBV 95 19 POL 39 EDUNLGNLNV XDXXXXXXXV B44 1280 HBV 90 18 POL 22 EEELPRLA XEXXXXXA B44 1281 HBV 80 16 X 121 EELGEEIPL XEXXXXXXL B44 1282 HBV 90 18 NUC 32 IDPYKEFGA XDXXXXXXA B44 1283 HBV 85 17 POL 617 IDWKVOQRI XDXXXXXXI B44 1284 HBV 85 17 POL 617 IDWKVOQRIV XDXXXXXXXV B44 1285 HBV 100 20 POL 125 LDKGIKPY XDXXXXXY B44 1286 HBV 100 20 POL 125 LDKGIKPYY XDXXXXXXY B44 1287 HBV 80 16 X 9 LDPARDVL XDXXXXXL B44 17.0012 1288 HBV 80 16 X 9 LDPARDVLCL XDXXXXXXXL B44 17.0419 1289 HBV 95 19 ENV 195 LDSWWTSL XDXXXXXL B44 1290 HBV 95 19 ENV 195 LDSWWTSLNF XDXXXXXXXF B44 1291 HBV 90 18 ENV 195 LDSWWTSLNFL XDXXXXXXXXL B44 1292 HBV 85 17 NUC 31 LDTASALY XDXXXXXY B44 1293 HBV 80 16 NUC 31 LDTASALYREA XDXXXXXXXXA B44 1294 HBV 95 19 POL 417 LDVSAAFY XDXXXXXY B44 1295 HBV 90 18 ENV 261 LDYQGMLPV XDXXXXXXV B44 1296 HBV 95 19 POL 21 LEEELPRL XEXXXXXL B44 1297 HBV 90 18 POL 21 LEEELPRLA XEXXXXXXA B44 1298 HBV 90 18 POL 539 MDDVVLGA XDXXXXXA B44 1299 HBV 90 18 POL 539 MDDVVLGAKSV XDXXXXXXXXV B44 1300 HBV 90 18 NUC 30 MDIDPYKEF XDXXXXXXF B44 1301 HBV 90 18 NUC 30 MDIDPYKEFGA XDXXXXXXXXA B44 1302 HBV 95 19 ENV 15 PDHQLDPA XDXXXXXA B44 1303 HBV 80 18 ENV 15 PDHQLDPAF XDXXXXXXF B44 1304 HBV 100 20 NUC 45 PEHCSPHHTA XEXXXXXXXA B44 1305 HBV 100 20 NUC 45 PEHCSPHHTAL XEXXXXXXXXL B44 1306 HBV 85 17 NUC 28 RDLLDTASA XDXXXXXXA B44 1307 HBV 85 17 NUC 28 RDLLDTASAL XDXXXXXXXL B44 1308 HBV 85 17 NUC 28 RDLLDTASALY XDXXXXXXXXY B44 1309 HBV 95 19 X 13 RDVLCLRPV XDXXXXXXV B44 1310 HBV 95 19 X 13 RDVLCLRPVGA XDXXXXXXXXA B44 1311 HBV 75 15 NUC 141 RETVLEYL XEXXXXXL B44 1312 HBV 75 15 NUC 141 RETVLEYLV XEXXXXXXV B44 1313 HBV 90 18 POL 736 TDNSVVLSRKY XDXXXXXXXXY B44 1314 HBV 95 19 NUC 42 VELLSFLPSDF XEXXXXXXXXF B44 1315 HBV 80 16 X 120 WEELGEB XEXXXXXI B44 1316 HBV 80 16 X 120 WEELGEERL XEXXXXXXXL B44 1317 52

TABLE-US-00014 TABLE XIII HBV B58 SUPER MOTIF SEQ ID Source Conservancy Freq Protein Position Sequence String Supermotif Peptide Filed NO: HBV 85 17 POL 431 AAMPHLLV XAXXXXXV B58 1318 HBV 95 19 POL 632 AAPFTQCGY XAXXXXXXV B58 1319 HBV 85 17 NUC 34 ASALYREAL XSXXXXXXL B58 1320 HBV 100 20 POL 166 ASFCGSPY XSXXXXXY B58 26.0026 * 1321 HBV 100 20 POL 166 ASFCGSPYSW XSXXXXXXXW B58 1322 HBV 90 18 NUC 19 ASKLCLGW XSXXXXXW B58 1323 HBV 90 18 NUC 19 ASKLCLGWL XSXXXXXXL B58 1324 HBV 85 17 NUC 19 ASKLCLGWLW XSXXXXXXXW B58 1325 HBV 80 16 POL 822 ASPLHVAW XSXXXXXW B58 1326 HBV 80 16 ENV 329 ASVRFSWL XSXXXXXL B58 1327 HBV 80 16 ENV 329 ASVRFSWLSL XSXXXXXXXL B58 1328 HBV 80 16 ENV 329 ASVRFSWLSLL XSXXXXXXXXL B58 1329 HBV 95 19 POL 690 ATPTGWGL XTXXXXXL B58 1330 HBV 75 15 POL 690 ATPTGWGLAI XTXXXXXXXI B58 1331 HBV 95 19 X 61 CAFSSAGPCAL XSXXXXXL B58 1332 HBV 100 20 NUC 48 CSPHHTAL XSXXXXXL B58 1333 HBV 80 16 POL 471 CSRNLYVSL XSXXXXXXL B58 1334 HBV 95 19 POL 523 CSVVRRAF XSXXXXXF B58 1335 HBV 100 20 ENV 310 CTCIPIPSSW XTXXXXXXXW B58 1336 HBV 95 19 POL 689 DATPTGWDL XAXXXXXXL B58 5.0027 1337 HBV 75 15 POL 689 DATPTGWGLAI XAXXXXXXXXI B58 1338 HBV 95 19 ENV 196 DSWWTSLNF XSXXXXXXF B58 20.0120 1339 HBV 90 18 ENV 196 DSWWTSLNFL XSXXXXXXXL B58 1340 HBV 80 16 NUC 32 DTASALYREA XTXXXXXXXA B58 1341 HBV 80 16 PUC 32 DTASALYREAL XTXXXXXXXXL B58 1342 HBV 100 20 POL 17 EAGPLEEEL XAXXXXXXL B58 5.0028 1343 HBV 95 19 POL 374 ESRLVVDF XSXXXXXF B58 1344 HBV 95 19 POL 374 ESRLVVDFSQF XSXXXXXXXXF B58 1345 HBV 75 15 NUC 142 ETVLEYLV XTXXXXXV B58 1346 HBV 95 19 POL 631 FAAPFTQCGY XAXXXXXXXY B58 20.0254 * 1347 HBV 95 19 POL 687 FADATPTGW XAXXXXXXW B58 1348 HBV 95 19 POL 687 FADATPTGWGL XAXXXXXXXXL B58 1349 HBV 80 16 POL 821 FASPLHVAW XAXXXXXXW B58 1350 HBV 95 19 POL 396 FAVPNLQSL XAXXXXXXL B58 5.0029 * 1351 HBV 95 19 POL 658 FSPTYKAF XSXXXXXF B58 1352 HBV 95 19 POL 658 FSPTYKAFL XSXXXXXXL B58 1353 HBV 95 19 X 63 FSSAGPCAL XSXXXXXX B58 1354 HBV 90 18 X 63 FSSAGPCALRF XSXXXXXXXXF B58 1355 HBV 100 20 ENV 333 FSWLSLLV XSXXXXXV B58 1356 HBV 100 20 ENV 333 FSWLSLLVPF XSXXXXXXXF B58 20.0263 1357 HBV 100 20 ENV 333 FSWLSLLVPFV XSXXXXXXXXV B58 1358 HBV 90 18 POL 538 FSYMDDVV XSXXXXXV B58 17.0257 1359 HBV 90 18 POL 536 FSYMDDVVL XSXXXXXXL B58 1360 HBV 95 19 POL 656 FTFSPTYKAF XTXXXXXXXF B58 20.0262 1361 HBV 95 19 POL 656 FTFSPTYKAFL XTXXXXXXXXL B58 1362 HBV 90 18 POL 59 FTGLYSSTV XTXXXXXXV B58 20.0118 1363 HBV 95 19 POL 635 FTQCGYPAL XTXXXXXXL B58 5.0031 1364 HBV 190 38 POL 635 FTQCGYPALM XTXXXXXXXM B58 5.0085 1365 HBV 95 19 POL 518 FTSAICSV XTXXXXXV B58 1366 HBV 95 19 POL 518 FTSAICSVV XTXXXXXXV B58 5.0032 1367 HBV 95 19 X 50 GAHLSLRGL XAXXXXXXL B58 5.0040 1368 HBV 90 18 X 50 GAHLSLRGLPV XAXXXXXXXXV B58 1369 HBV 85 17 POL 545 GAKSVQHL XAXXXXXL B58 1370 HBV 85 17 POL 545 GAKSVQHLESL XAXXXXXXXXL B58 1371 HBV 75 15 ENV 134 GSSSGTVNPV XSXXXXXXXV B58 1372 HBV 90 18 POL 735 GTDNSVVL XTXXXXXL B58 1373 HBV 75 15 ENV 13 GTNLSVPNPL XTXXXXXXXL B58 1374 HBV 80 16 POL 763 GTSFVYVPSAL XTXXXXXXXXL B58 1375 HBV 85 17 POL 715 HTAELLAACF XTXXXXXXXF B58 1376 HBV 100 20 NUC 52 HTALRQAI XTXXXXXI B58 1377 HBV 95 19 NUC 52 HTALAQAIL XTXXXXXXL B58 5.0021 1378 HBV 95 19 NUC 52 HTALROAILCW XTXXXXXXXXW B58 1379 HBV 100 20 POL 149 HTLWKAGI XTXXXXXI B58 1380 HBV 100 20 POL 149 HTLWKAGIL XTXXXXXXL B58 5.0033 1381 HBV 100 20 POL 149 HTLWKAGILY XTXXXXXXXY B58 1.0542 * 1382 HBV 90 18 NUC 105 ISQLTFGRETV XSXXXXXXXXV B58 1383 HBV 85 17 POL 547 KSVQHLESL XSXXXXXXL B58 1384 HBV 95 19 POL 574 KTKRWGYSL XTXXXXXXL B58 5.0034 1385 HBV 85 17 POL 574 KTKRWGYSLNF XTXXXXXXXXF B58 1386 HBV 90 18 POL 534 LAFSYMDDV XAXXXXXXV B58 20.0119 1387 HBV 90 18 POL 534 LAFSYMDDVV XAXXXXXXXV B58 20.0257 1388 HBV 90 18 POL 534 LAFSYMDDVVL XAXXXXXXXXL B58 1389 HBV 95 19 POL 515 LAQFTSAI XAXXXXXI B58 1390 HBV 95 19 POL 515 LAQFTSAICSV XAXXXXXXXXV B58 1391 HBV 95 19 NUC 45 LSFLPSDF XSXXXXXF B58 1392 HBV 95 19 NUC 45 LSFLPSDFF XSXXXXXXF B38 20.0123 1393 HBV 95 19 POL 415 LSLDVSAAF XSXXXXXXF B58 1394 HBV 95 19 POL 415 LSLDVSAAFY XSXXXXXXXY B58 2.0239 * 1395 HBV 100 20 ENV 336 LSLLVPFV XSXXXXXV B58 1396 HBV 100 20 ENV 336 LSLLVPFVQW XSXXXXXXXW B58 1397 HBV 100 20 ENV 336 LSLLVPFVQWF XSXXXXXXXXF B58 1398 HBV 95 19 X 53 LSLRGLPV XSXXXXXV B58 1399 HBV 95 19 X 53 LSLRGLPVCAF XSXXXXXXXXF B58 1400 HBV 95 19 POL 510 LSPFLLAQFP XSXXXXXXF B58 1401 HBV 75 15 ENV 349 LSPTVWLSV XSXXXXXXV B58 1402 HBV 75 15 ENV 349 LSPTVWLSVI XSXXXXXXXI B58 1403 HBV 75 15 ENV 349 LSPTVWISVIW XSXXXXXXXXW B58 1404 HBV 85 17 POL 742 LSRKYTSF XSXXXXXF B58 1405 HBV 85 17 POL 742 LSRKYTSFPW XSXXXXXXXW B58 1406 HBV 85 17 POL 742 LSRKVTSFPWL XSXXXXXXXXL B58 1407 HBV 90 18 POL 408 LSSNLSWL XSXXXXXL B58 1408 HBV 90 18 POL 408 LSSNLSWLSL XSXXXXXXXL B58 1409 HBV 100 20 NUC 140 LSTLPETTV XSXXXXXXV B58 1410 HBV 100 20 NUC 140 LSTLPETTVV XSXXXXXXXV B58 1411 HBV 75 15 ENV 16 LSVPNPLGF XSXXXXXXF B58 1412 HBV 100 20 POL 412 LSWLSLDV XSXXXXXV B58 1413 HBV 75 15 POL 3 LSYQHFRKL XSXXXXXXL B58 1414 HBV 75 15 POL 3 LSYQHFRKLL XSXXXXXXXL B58 1415 HBV 75 15 POL 3 LSYQHFRKLLL XSXXXXXXXXL B58 1416 HBV 95 19 NUC 108 LTFGRETV XTXXXXXV B58 1417 HBV 75 15 NUC 137 LTFGRETVL XTXXXXXXL B58 1418 HBV 75 15 NUC 137 LTFGRETVLEY XTXXXXXXXXY B58 1419 HBV 90 18 ENV 189 LTIPQSLDSW XTXXXXXXXW B58 1420 HBV 90 18 ENV 189 LTIPQSLDSWW XTXXXXXXXXW B58 1421 HBV 90 18 POL 404 LTNLLSSNL XTXXXXXXL B58 1422 HBV 90 18 POL 404 LTNLLSSNLSW XTXXXXXXXXW B58 1423 HBV 80 16 ENV 185 LTRILTIPQSL XTXXXXXXXXL B58 1424 HBV 85 17 POL 99 LTVNEKRRL XTXXXXXXL B58 1425 HBV 75 15 X 103 MSTTDLEAY XSXXXXXXY B58 2.0126 * 1426 HBV 75 15 X 103 MSTTDLEAYF XSXXXXXXXF B58 1427 HBV 100 20 NUC 138 NAPILSTL XAXXXXXL B58 1428 HBV 90 18 POL 738 NSVVLSRKY XSXXXXXXY B58 2.0123 1429 HBV 100 20 POL 430 PAAMPHLL XAXXXXXL B58 1430 HBV 85 17 POL 430 PAAMPHLLV XAXXXXXXV B58 1431 HBV 90 18 POL 775 PADDPSRGRL XAXXXXXXXL B58 1432 HBV 90 18 ENV 131 PAGGSSSGTV XAXXXXXXXV B58 1433 HBV 95 19 POL 641 PALMPLYACI XAXXXXXXXI B58 5.0087 1434 HBV 80 16 X 11 PARDVLCL XAXXXXXL B58 1435 HBV 75 15 X 11 PARDVLCLRPV XAXXXXXXXXV B58 1436 HBV 90 18 POL 355 PARVTGGV XAXXXXXV B58 1437 HBV 90 18 POL 355 PARVTGGVF XAXXXXXXF B58 1438 HBV 90 18 POL 355 PARVTGGVFL XAXXXXXXXL B58 1439

HBV 90 18 POL 355 PARVTGGVFLV XAXXXXXXXXV B58 1440 HBV 95 19 NUC 130 PAYRPPNAPI XAXXXXXXXI B58 5.0081 1441 HBV 95 19 NUC 130 PAYRPPNAPIL XAXXXXXXXXL B58 1442 HBV 90 18 POL 779 PSRGPLGL XSXXXXXL B58 1443 HBV 75 15 POL 692 PTGWGLAI XTXXXXXI B58 1444 HBV 85 17 POL 797 PTTGRTSL XTXXXXXL B58 1445 HBV 85 17 POL 797 PTTGRTSLY XTXXXXXXY B58 1.0208 * 1446 HBV 80 16 NUC 15 PTVQASKL XTXXXXXL B58 1447 HBV 80 16 NUC 15 PTVQASKLCL XTXXXXXXXL B58 1448 HBV 75 15 ENV 351 PTVWLSVI XTXXXXXI B58 1449 HBV 75 15 ENV 351 PTVWLSVIW XTXXXXXXW B58 1450 HBV 150 30 ENV 351 PTVWLSVIWM XTXXXXXXXM B58 1451 HBV 95 19 POL 654 QAFTFSPTY XAXXXXXXY B58 20.0127 1452 HBV 80 16 ENV 179 QAGFFLLTRIL XAXXXXXXXXL B58 1453 HBV 90 18 NUC 57 QAILCWGEL XAXXXXXXL B58 1454 HBV 180 36 NUC 57 QAILCWLELM XAXXXXXXXM B58 1456 HBV 80 16 ENV 107 QAMQWNSTTF XAXXXXXXXF B58 1456 HBV 80 16 NUC 18 QASKLCLGW XAXXXXXXW B58 1457 HBV 80 16 NUC 18 QASKLCLGWL XAXXXXXXXL B58 1458 HBV 75 15 NUC 18 QASKLCLGWLW XAXXXXXXXXW B58 1459 HBV 90 18 ENV 193 QSLDSWWTSL XSXXXXXXXL B58 F126.63 1460 HBV 90 18 POL 402 QSLTNLLSSNL XSXXXXXXXXL B58 1461 HBV 95 19 POL 528 RAFPHCLAF XAXXXXXXF B58 20.0125 1462 HBV 95 19 POL 528 RAFPHCLAFSY XAXXXXXXXXY B58 26.0550 * 1463 HBV 90 18 POL 353 RTPARVTSGGV XTXXXXXXXV B58 1464 HBV 90 18 POL 353 RTPARVTGGVF XTXXXXXXXXF B58 1465 HBV 90 18 X 65 SAGPCALRF XAXXXXXXF B58 26.0152 1466 HBV 95 19 POL 520 SAICSVVRRAF XAXXXXXXXXF B58 1467 HBV 90 18 NUC 35 SALYREAL XAXXXXXL B58 1468 HBV 100 20 POL 165 SASFCGSPY XAXXXXXXY B58 20.0117 * 1469 HBV 100 20 POL 165 SASFCGSPYSW XAXXXXXXXXW B58 1470 HBV 95 19 X 64 SSAGPCAL XSXXXXXL B58 1471 HBV 90 18 X 64 SSAGPCALRF XSXXXXXXXF B58 26.0374 1472 HBV 75 15 ENV 136 SSGTVNPV XSXXXXXV B58 1473 HBV 90 18 POL 409 SSNLSWLSL XSXXXXXXL B58 1474 HBV 90 18 POL 409 SSNLSWLSLDV XSXXXXXXXXV B58 1475 HBV 75 15 ENV 135 SSSGTVNPV XSXXXXXXV B58 1476 HBV 100 20 NUC 141 STLPETTV XTXXXXXV B58 1477 HBV 100 20 NUC 141 STLPETTVV XTXXXXXXV B58 5.0024 1478 HBV 75 15 X 104 STTDLEAY XTXXXXXY B58 1479 HBV 75 15 X 104 STTDLEAYF XTXXXXXXF B58 1480 HBV 85 17 POL 716 TAELLAACF XAXXXXXXF B58 1481 HBV 95 19 NUC 53 TALRQAIL XAXXXXXL B58 1482 HBV 95 19 NUC 53 TALRQAILCW XAXXXXXXXXW B58 1483 HBV 80 16 NUC 33 TASALYREAL XAXXXXXXXL B58 1484 HBV 95 19 POL 519 TSAICSVV XSXXXXXV B58 1485 HBV 80 16 POL 764 TSFVYYPSAL XSXXXXXXXL B58 1486 HBV 80 16 ENV 168 TSGFLGPL XSXXXXXL B58 1487 HBV 75 15 ENV 168 TSQFLGPLL XSXXXXXXL B58 1488 HBV 75 15 ENV 168 TSGFLGPLLV XSXXXXXXXV B58 1489 HBV 75 15 ENV 168 TSGFLGPLLVL XSXXXXXXXXL B58 1490 HBV 75 15 X 105 TTDLEAYF XTXXXXXF B58 1491 HBV 85 17 POL 798 TTGRTSLY XTXXXXXY B58 26.0030 1492 HBV 95 19 POL 37 VAEDLNLGNL XAXXXXXXXL B58 5.0089 1493 HBV 100 20 POL 48 VSIPWTHKV XSXXXXXXV B58 1494 HBV 85 19 POL 391 VSWPKFAV XSXXXXXV B58 1495 HBV 95 19 POL 391 VSWPKFAVPNL XSXXXXXXXXL B58 1496 HBV 100 20 POL 358 VTGGVFLV XTXXXXXV B58 1497 HBV 85 17 ENV 66 WSPQAQGI XSXXXXXI B58 1498 HBV 85 17 ENV 66 WSPQAQGIL XSXXXXXXL B58 1499 HBV 100 20 POL 52 WTHKVGNF XTXXXXXF B58 1500 HBV 95 19 POL 52 WTHKVGNFTGL XTXXXXXXXXL B58 1501 HBV 80 16 POL 493 YSHPIILGF XSXXXXXXF B58 1502 HBV 85 17 POL 580 YSLNFMGY XSXXXXXY B58 26.0032 1503 HBV 75 15 POL 580 YSLNFMGYV XSXXXXXXV B58 1504 HBV 75 15 POL 580 YSLNFMGYVI XSXXXXXXXI B58 1505 HBV 85 17 POL 746 YTSFPWLL XTXXXXXL B58 1506 189

TABLE-US-00015 TABLE XIV HBV B62 SUPER MOTIF SEQ ID Source Conservancy Freq Protein Position Sequence String Supermotif Peptide Filed NO: HBV 95 19 POL 521 AICSVVRRAF XIXXXXXXXF B62s 1507 HBV 90 18 NUC 58 AILCWGELM XIXXXXXXM B62s 1508 HBV 95 19 POL 642 ALMPLYACI XLXXXXXXI B62s 3.0012 * 1509 HBV 95 19 NUC 54 ALRQAILCW XLXXXXXXW B62s 1510 HBV 80 16 ENV 106 AMQWMSTTF XMXXXXXXF B62s 1511 HBV 95 19 POL 633 APFTQCGY XPXXXXXY B62s 19.0013 1512 HBV 95 19 POL 516 AQFTSAICSV XQXXXXXXXV B62s 1513 HBV 95 19 POL 516 AQPTSAICSVV XQXXXXXXXXV B62s 1514 HBV 100 20 ENV 312 CIPIPSSW XIXXXXXW B62s 1515 HBV 100 20 ENV 312 CIPIPSSWAF XIXXXXXXXF B62s 1516 HBV 90 18 POL 533 CLAFSYMDDV XLXXXXXXXV B62s 1.0559 1517 HBV 90 18 POL 533 CLAFSYMDDVV XLXXXXXXXXV B62s 1518 HBV 85 17 NUC 23 CLGWLWGM XLXXXXXM B62s 1519 HBV 85 17 NUC 23 CLGWLWGMDI XLXXXXXXXI B62s 2.0229 1520 HBV 95 19 ENV 253 CLIFLLVLLDY XLXXXXXXXXY B62s 26.0548 1521 HBV 95 19 ENV 239 CLRRFIIF XLXXXXXF B62s 1522 HBV 75 15 ENV 239 CLRRFIIFLF XLXXXXXXXF B62s 1523 HBV 75 15 ENV 239 CLRRFIIFLFI XLXXXXXXXXI B62s Chisari 1524 HBV 90 18 NUC 107 CLTFGRETV XLXXXXXXV B62s 1.0160 1525 HBV 80 16 X 7 CQLDPARDV XQXXXXXXV B62s 1526 HBV 85 17 POL 622 CQRVGLLGF XIXXXXXF B62s 1527 HBV 90 18 NUC 31 DIDPYKEF XIXXXXXF B62s 1528 HBV 85 17 NUC 29 DLLDTASALY XLXXXXXXXY B62s 1.0519 * 1529 HBV 95 19 POL 40 DUNLGNLNV XLXXXXXXV B62s 1.0164 1530 HBV 95 19 POL 40 DLNLGNLNVSI XLXXXXXXXXI B62s 1531 HBV 80 16 ENV 122 DPRVRGLY XPXXXXXY B62s 1532 HBV 95 19 X 14 DVLCLRPV XVXXXXXV B62s 1533 HBV 90 18 POL 541 DVVLGAKSV XVXXXXXXV B62s 1.0190 1534 HBV 95 19 NUC 43 ELLSFLPSDF XLXXXXXXXF B62s 1535 HBV 95 19 NUC 43 ELLSFLPSDFF XLXXXXXXXXF B62s 1536 HBV 80 16 ENV 248 FILLLCLI XIXXXXXI B62s Chisari 1537 HBV 80 16 ENV 248 FILLLCLIF XIXXXXXXF B62s 1538 HBV 80 16 ENV 246 FLFILLLCLI XLXXXXXXXI B62s 3.0206 1539 HBV 80 16 ENV 246 FLFILLLCLIF XLXXXXXXXXF B62s 1540 HBV 95 19 POL 513 FLLAQPTSAI XLXXXXXXXI B62s 1147.13 * 1541 HBV 80 16 ENV 183 FLLTRILTI XLXXXXXXI B62s 3.0005 * 1542 HBV 95 19 ENV 256 FLLVLLDY XLXXXXXY B62s 26.0027 1543 HBV 95 19 ENV 256 FLLVLLDYQGM XLXXXXXXXXM B62s 1544 HBV 75 15 ENV 130 FPAGGSSSGTV XPXXXXXXXXV B62s 1545 HBV 85 17 ENV 14 FPQHQLDPAF XPXXXXXXXF B62s 20.0274 1546 HBV 95 19 POL 530 FPHCLAFSY XPXXXXXXY B62s 15.0037 * 1547 HBV 95 19 POL 530 FPHCLAFSYM XPXXXXXXXM B62s 16.0217 * 1548 HBV 75 15 POL 749 FPWLLGCAANW XPXXXXXXXXW B62s 1549 HBV 95 19 ENV 346 FVGLSPTV XYXXXXXV B62s 1550 HBV 95 19 ENV 346 FVGLSPTVW XVXXXXXXW B62s 1551 HBV 90 18 X 132 FVLGGCRHKLV XVXXXXXXXXV B62s 1552 HBV 95 19 POL 627 GLLGFAAPF XLXXXXXXF B62s 20.0124 1553 HBV 95 19 POL 509 GLSPFLLAQF XLXXXXXXXF B62s 1554 HBV 75 15 ENV 348 GLSPTVWLSV XLXXXXXXXV B62s 1.0518 * 1555 HBV 75 15 ENV 348 GLSPTVWLSVI XLXXXXXXXXI B62s Chisari 1556 HBV 85 17 NUC 29 GMDIDPYKEF XMXXXXXXXF B62s 26.0372 1557 HBV 95 19 ENV 173 GPLLVLQAGF XPXXXXXXXF B62s 15.0212 1558 HBV 95 19 ENV 173 GPLLVLQAGFF XPXXXXXXXXF B62s 26.0556 1559 HBV 95 19 NUC 123 GVWIRTPPAY XVXXXXXXXY B62s 1.0525 1560 HBV 75 15 POL 569 HLNPNKTKRW XLXXXXXXXW B62s 1561 HBV 90 18 X 52 HLSLRGLPV XLXXXXXXV B62s 1.0212 1562 HBV 80 16 POL 491 HLYSHPII XLXXXXXI B62s 17.0256 1563 HBV 80 16 POL 491 HLYSHPIILGF XLXXXXXXXXF B62s 1564 HBV 85 17 POL 429 HPAAMPHLLV XPXXXXXXXV B62s 20.0273 * 1565 HBV 80 16 POL 495 HPIILGFRKI XPXXXXXXXI B62s 1566 HBV 80 16 POL 497 IILGFRKI XIXXXXXI B62s 17.0124 * 1567 HBV 80 16 POL 497 IILGFRKIPM XIXXXXXXXM B62s 1568 HBV 90 18 NUC 59 ILCWGELM XLXXXXXM B62s 1569 HBV 80 16 POL 498 ILGFRKIPM XLXXXXXXM B62s 3.0016 1570 HBV 100 20 ENV 249 ILLLCLIF XLXXXXXF B62s 1571 HBV 100 20 ENV 249 ILLLCLIFLLV XLXXXXXXXXV B62s Chisari 1572 HBV 80 16 POL 760 ILRGTSFV XLXXXXXV B62s 1573 HBV 80 16 POL 760 ILRGTSFVY XLXXXXXXY B62s 1.0205 * 1574 HBV 80 16 POL 760 ILRGTSFVYV XLXXXXXXXV B62s 1.0573 * 1575 HBV 100 20 NUC 139 ILSTLPETTV XLXXXXXXXV B62s 1.0526 1576 HBV 100 20 NUC 139 ILSTLPETTVV XLXXXXXXXXV B62s * 1577 HBV 90 18 ENV 188 ILTIPQSLDSW XLXXXXXXXXW B62s 1578 HBV 100 20 ENV 313 IPIPSSWAF XPXXXXXXF B62s 15.0032 * 1579 HBV 80 16 POL 504 IPMGVGLSPF XPXXXXXXXF B62s 1580 HBV 90 18 ENV 191 IPQSLDSW XPXXXXXW B62s 19.0004 1581 HBV 90 18 ENV 191 IPQSLDSWW XPXXXXXXW B62s 15.0030 * 1582 HBV 100 20 POL 50 IPWTHKVGNF XPXXXXXXXF B62s 15.0209 1583 HBV 90 18 POL 625 IVGLLGFAAPF XVXXXXXXXXF B62s 1584 HBV 80 16 POL 503 KIPMGVGLSPF XIXXXXXXXXF B62s 1585 HBV 85 17 NUC 21 KLCLGWLW XLXXXXXW B62s 1586 HBV 85 17 NUC 21 KLCLGWLWGM XLXXXXXXXM B62s 3.0209 1587 HBV 95 19 POL 489 KLHLYSHPI XLXXXXXXI B62s 3.0009 1588 HBV 80 16 POL 489 KLHLYSHPII XLXXXXXXXI B62s 1589 HBV 75 15 POL 108 KLIMPARF XLXXXXXF B62s 1590 HBV 75 15 POL 108 KLIMPARFY XLXXXXXXY B62s 1.0171 1591 HBV 80 16 POL 610 KLPVNRPI XLXXXXXI B62s 1592 HBV 80 16 POL 610 KLPVNRPIDW XLXXXXXXXW B62s 1593 HBV 95 19 POL 653 KQAFTFSPTY XQXXXXXXXY B62s 20.0256 1594 HBV 95 19 POL 55 KVGNFTGLY XVXXXXXXY B62s 1.0166 1595 HBV 95 19 ENV 254 LIFLLVLLDY XIXXXXXXXY B62s 1.0899 1596 HBV 100 20 POL 109 LIMPARFY XIXXXXXY B62s 26.0028 1597 HBV 95 19 POL 514 LLAQPTSAI XLXXXXXXI B62s 3.0010 1598 HBV 100 20 ENV 251 LLCLIFLLV XLXXXXXXV B62s 1.0835 1599 HBV 85 17 NUC 30 LLDTASALY XLXXXXXXY B62s 1.0155 1600 HBV 90 18 ENV 260 LLDYQGMLPV XLXXXXXXXV B62s 1.0516 1601 HBV 80 16 POL 752 LLGCAANW XLXXXXXW B62s 1602 HBV 80 16 POL 752 LLGCAANWI XLXXXXXXI B62s 3.0013 1603 HBV 95 19 POL 628 LLGFAAPF XLXXXXXF B62s 1604 HBV 75 15 ENV 63 LLGWSPQAQGI XLXXXXXXXXI B62s 1605 HBV 100 20 ENV 250 LLLCLIFLLV XLXXXXXXXV B62s 1.0897 1606 HBV 100 20 ENV 378 LLPIFFCLW XLXXXXXXW B62s 1607 HBV 100 20 ENV 378 LLPIFFCLWV XLXXXXXXXV B62s 1.0904 1608 HBV 100 20 ENV 378 LLPIFFCLWVY XLXXXXXXXXY B62s 26.0549 1609 HBV 95 19 NUC 44 LLSFLFSDF XLXXXXXXF B62s 1610 HBV 95 19 NUC 44 LLSFLPSDFF XLXXXXXXXF B62s 1611 HBV 90 18 POL 407 LLSSNLSW XLXXXXXW B62s 1612 HBV 80 16 ENV 184 LLTRILTI XLXXXXXI B62s Chisari 1613 HBV 80 16 POL 436 LLVGSSGL XLXXXXXL B62s 1614 HBV 95 19 ENV 257 LLVLLDYQGM XLXXXXXXXM B62s 3.0207 1615 HBV 95 19 ENV 175 LLVLQAGF XLXXXXXF B62s 1616 HBV 95 19 ENV 175 LLVLQAGFF XLXXXXXXF B62s 20.0121 1617 HBV 100 20 ENV 338 LLVPFVQW XLXXXXXW B62s 1618 HBV 100 20 ENV 338 LLVPFVQWF XLXXXXXXF B62s 1619 HBV 95 19 ENV 338 LLVPFVQWFV XLXXXXXXXV B62s 1.0930 1620 HBV 85 17 NUC 100 LLWFHISCLTF XLXXXXXXXXF B62s 1621 HBV 95 19 POL 643 LMPLYACI XMXXXXXI B62s 17.0130 1622 HBV 100 20 ENV 379 LPIFFCLW XPXXXXXW B62s 19.0007 1623 HBV 100 20 ENV 379 LPIFFCLWV XPXXXXXXV B62s 15.0034 1624 HBV 100 20 ENV 379 LPIFFCLWVY XPXXXXXXXY B62s 15.0215 1625 HBV 100 20 ENV 379 LPIFFCLWVYI XPXXXXXXXXI B62s 26.0558 1626 HBV 100 20 POL 123 LPLDKGIKPY XPXXXXXXXY B62s 15.0210 1627 HBV 100 20 POL 123 LPLDKGIKPYY XPXXXXXXXXY B62s 26.0560 1628

HBV 80 16 POL 611 LPVNRPIDW XPXXXXXXW B62s 1629 HBV 80 16 POL 611 LPVNRPIDWKV XPXXXXXXXXV B62s 1630 HBV 80 16 ENV 178 LQAGFFLLTRI XQXXXXXXXXI B62s 1631 HBV 95 19 ENV 258 LVLLDYQGM XVXXXXXXM B62s 3.0034 1632 HBV 95 19 ENV 176 LVLDAGFF XVXXXXXF B62s 1633 HBV 100 20 ENV 339 LVPFVQWF XVXXXXXF B62s 1634 HBV 95 19 ENV 339 LVPFVQWFV XVXXXXXXV B62s 1.0877 1635 HBV 90 18 NUC 119 LVSFGVWI XVXXXXXI B62s Chisari 1636 HBV 100 20 POL 377 LVVDFSQF XVXXXXXF B62s 1637 HBV 85 17 ENV 0 MMWYWGPSLY XMXXXXXXXY B62s 1039.01 1638 HBV 100 20 POL 1 MPLSYQHF XPXXXXXF B62s 19.0010 1639 HBV 80 16 ENV 109 MQWNSTTF XQXXXXXF B62s 1640 HBV 95 19 POL 42 NLGNLNVSI XLXXXXXXI B62s 3.0008 1641 HBV 95 19 POL 42 NLGNLNVSIPW XLXXXXXXXXW B62s 1642 HBV 90 18 POL 406 NLLSSNLSW XLXXXXXXW B62s 1643 HBV 95 19 POL 45 NLNVSIPW XLXXXXXW B62s 1644 HBV 75 15 ENV 15 NLSVPNPLGF XLXXXXXXXF B62s 1645 HBV 90 18 POL 411 NLSWLSLDV XLXXXXXXV B62s 1.0185 1646 HBV 75 15 POL 571 NPNKTKRW XPXXXXXW B62s 1647 HBV 75 15 POL 571 NPNKTKRWGY XPXXXXXXXY B62s 1648 HBV 100 20 POL 47 NVSIPWTHKV XVXXXXXXXV B62s 1.0532 1649 HBV 85 17 POL 616 PIDWKVCQRI XIXXXXXXXI B62s Chisari 1650 HBV 85 17 POL 616 PIDWKCQRIV XIXXXXXXXXV B62s 1651 HBV 100 20 ENV 380 PIFFCLWV XIXXXXXV B62s 1652 HBV 100 20 ENV 380 PIFFCLWVY XIXXXXXXY B62s 1.0843 1653 HBV 100 20 ENV 380 PIFFCLWVYI XIXXXXXXXI B62s 20.0258 1654 HBV 80 16 POL 496 PIILGFRKI XIXXXXXXI B62s 927.48 1655 HBV 80 16 POL 496 PIILGFRKIPM XIXXXXXXXXM B62s 1656 HBV 100 20 NUC 136 PILSTLPETTV XIXXXXXXXXV B62s Chisari 1657 HBV 100 20 ENV 314 PIPSSWAF XIXXXXXF B62s 1658 HBV 100 20 POL 124 PLDKGIKPY XLXXXXXXY B62s 1.0174 1659 HBV 100 20 POL 124 PLDKGIKPYY XLXXXXXXXY B62s 1.0541 1660 HBV 20 20 ENV 377 PLLPIFFCLW XLXXXXXXXW B62s 1661 HBV 100 20 ENV 377 PLLPIFFCLWV XLXXXXXXXXV B62s 1662 HBV 95 19 ENV 174 PLLVLQAGF XLXXXXXXF B62s 1663 HBV 95 19 ENV 174 PLLVLQAGFF XLXXXXXXXF B62s 1664 HBV 80 16 POL 505 PMGVGLSPF XMXXXXXXF B62s 1665 HBV 95 19 NUC 129 PPAYRPPNAPI XPXXXXXXXXI B62s 26.0563 1666 HBV 85 17 ENV 58 PPHGGLLGW XPXXXXXXW B62s 20.0141 1667 HBV 80 16 ENV 106 PQAMQWNSTT XQXXXXXXXXF B62s 1668 HBV 90 18 ENV 192 PQSLDSWW XQXXXXXW B62s 1669 HBV 85 17 POL 612 PVNRPIDW XVXXXXXW B62s 1670 HBV 85 17 POL 612 PVNRPIDWKV XVXXXXXXXV B62s 1.0566 1671 HBV 80 16 X 8 QLDPARDV XLXXXXXV B62s Chisari 1672 HBV 95 19 POL 665 QVFADATPTGW XVXXXXXXXXW B62s 1673 HBV 90 18 POL 624 RIVGLLGF XIXXXXXF B62s 1674 HBV 75 15 POL 106 RLKLIMPARF XLXXXXXXXF B62s 1675 HBV 75 15 POL 106 RLKLIMPARFY XLXXXXXXXXY B62s 1676 HBV 95 19 POL 376 RLVVDFSQF XLXXXXXXF B62s 20.0122 1677 HBV 80 16 POL 615 RPIDWKVCQRI XPXXXXXXXXI B62s 1678 HBV 90 18 NUC 56 RQAILCWGELM XQXXXXXXXXM B62s 1679 HBV 90 18 NUC 98 RQLLWFHI XQXXXXXI B62s 1680 HBV 75 15 POL 818 RVHFASPLHV XVXXXXXXXV B62s 1.0576 1681 HBV 100 20 POL 357 RVTGGVFLV XVXXXXXXV B62s 1.0181 1682 HBV 100 20 POL 49 SIPWTHKV XIXXXXXV B62s 1683 HBV 100 20 POL 49 SIPWTHKVGNF XIXXXXXXXXF B62s 1684 HBV 95 19 ENV 194 SLDSWWTSLNF XLXXXXXXXXF B62s 1685 HBV 95 19 POL 416 SLDVSAAF XLXXXXXF B62s 1686 HBV 95 19 POL 416 SLDVSAAFY XLXXXXXXY B62s 1.0186 * 1687 HBV 100 20 ENV 337 SLLVPFVQW XLXXXXXXW B62s 1688 HBV 100 20 ENV 337 SLLVPFVQWF XLXXXXXXXF B62s 1689 HBV 95 19 ENV 337 SLLVPFVQWFV XLXXXXXXXXV B62s 1690 HBV 75 15 POL 581 SLNFMGYV XLXXXXXV B62s 1691 HBV 75 15 POL 581 SLNFMGYVI XLXXXXXXI B62s 3.0011 1692 HBV 95 19 X 54 SLRGLPVCAF XLXXXXXXXF B62s 20.0259 1693 HBV 95 19 POL 511 SPFLLAQF XPXXXXXF B62s 19.0012 * 1694 HBV 100 20 NUC 49 SPHHTALRQAI XPXXXXXXXXI B62s 26.0567 * 1695 HBV 75 15 ENV 350 SPTVWLSV XPXXXXXV B62s 1696 HBV 75 15 ENV 330 SPTVWLSVI XPXXXXXXI B62s 1308.16 1697 HBV 75 15 ENV 350 SPTVWLSVIW XPXXXXXXXW B62s 1308.17 1698 HBV 75 15 ENV 350 SPTVWLSVIWM XPXXXXXXXXM B62s 1699 HBV 75 15 ENV 17 SVPNPLGF XVXXXXXF B62s 1700 HBV 80 16 ENV 330 SVRFSWLSLLV XVXXXXXXXXV B62s 1701 HBV 90 18 POL 739 SVVLSRKY XVXXXXXY B62s 26.0029 1702 HBV 85 17 POL 739 SVVLSRKYTSF XVXXXXXXXXF B62s 1703 HBV 90 18 ENV 190 TIPQSLDSW XIXXXXXXW B62s 1704 HBV 90 18 ENV 190 TIPQSLDSWW XIXXXXXXXW B62s 1705 HBV 100 20 NUC 142 TLPETTVV XLXXXXXV B62s 1706 HBV 100 20 POL 150 TLWKAGILY XLXXXXXXY B62s 1.0177 * 1707 HBV 90 18 POL 354 TPARVTGGV XPXXXXXXV B62s 15.0033 * 1708 HBV 90 18 POL 354 TPARVTGGVF XPXXXXXXXF B62s 15.0214 * 1709 HBV 75 15 ENV 57 TPPHGGLLGW XPXXXXXXXW B62s 1308.04 1710 HBV 75 15 POL 691 TPTGWGLAI XPXXXXXXI B62s 1711 HBV 95 19 POL 636 TQCGYPALM XQXXXXXXM B62s 1712 HBV 80 16 NUC 16 TVQASKLCLGW XVXXXXXXXXW B62s 1713 HBV 75 15 ENV 352 TVWLSVIW XVXXXXXW B62s 1714 HBV 75 15 ENV 352 TVWLSVIWM XVXXXXXXM B62s 3.0035 1715 HBV 90 18 X 133 VLGGCRHKLV XLXXXXXXXV B62s 1.0589 1716 HBV 95 19 ENV 259 VLLDYQGM XLXXXXXM B62s 17.0107 1717 HBV 90 18 ENV 259 VLLDYQGMLPV XLXXXXXXXXV B62s 1147.14 * 1718 HBV 85 17 POL 741 VLSRKYTSF XLXXXXXXF B62s 1719 HBV 85 17 POL 741 VLSRKYTSFPW XLXXXXXXXXW B62s 1720 HBV 95 19 ENV 340 VPFVQWFV XPXXXXXV B62s 19.0006 * 1721 HBV 80 16 NUC 17 VQASKLCLGW XQXXXXXXXW B62s 1722 HBV 95 19 ENV 343 VQWFVGLSPTV XQXXXXXXXXV B62s 1723 HBV 90 18 POL 542 VVGAKSV XVXXXXXV B62s 1724 HBV 80 16 POL 759 WILRGTSF XIXXXXXXF B62s 1725 HBV 80 16 POL 759 WILRGTSFV XIXXXXXXV B62s 1.0204 * 1726 HBV 80 16 POL 759 WILRGTSFVY XIXXXXXXXY B62s 1.0572 1727 HBV 80 16 POL 759 WILRGTSFVYV XIXXXXXXXXV B62s 1728 HBV 95 19 NUC 125 WIRTPPAY XIXXXXXY B62s 26.0031 1729 HBV 80 16 POL 751 WLLGCAANW XLXXXXXXW B62s 1730 HBV 80 16 POL 751 WLLGCAANWI XLXXXXXXXI B62s Chisari 1731 HBV 95 19 POL 414 WLSLDVSAAF XLXXXXXXXF B62s 1732 HBV 95 19 POL 414 WLSLDVSAAFY XLXXXXXXXXY B62s 26.0551 1733 HBV 100 20 ENV 335 WLSLLVPF XLXXXXXF B62s 1734 HBV 100 20 ENV 335 WLSLLVPFV XLXXXXXXV B62s 1.0838 * 1735 HBV 100 20 ENV 335 WLSLLVPFVQW XLXXXXXXXXW B62s 1736 HBV 85 17 NUC 26 WLWGMDIDPY XLXXXXXXXY B62s 1.0774 * 1737 HBV 95 19 ENV 237 WMCLRRFI XMXXXXXI B62s 1738 HBV 95 19 ENV 237 WMCLRRFI XMXXXXXXI B62s 3.0031 * 1739 HBV 95 19 ENV 237 VMCLRRFIIF XMXXXXXXXF B62s 20.0266 1740 HBV 85 17 ENV 359 WMMWYWGPSL XMXXXXXXXL B62s 1.0901 * 1741 HBV 100 20 POL 147 YLHTLWKAGI XLXXXXXXXI B62s 7.0066 1742 HBV 100 20 POL 122 YLPLDKGI XLXXXXXI B62s 1743 HBV 100 20 POL 122 YLPLDKGIKPY XLXXXXXXXXY B62s 26.0553 1744 HBV 90 18 NUC 118 YLVSFGVW XLXXXXXW B62s 1745 HBV 90 18 NUC 118 YLVSFGVWI XLXXXXXXI B62s 3.0007 * 1746 HBV 95 19 POL 640 YPALMPLY XPXXXXXY B62s 19.0014 * 1747 HBV 95 19 POL 640 YPALMPLYACI XPXXXXXXXXI B62s 26.0570 1748 242

TABLE-US-00016 TABLE XV HBV A01 Motif (With Binding Information) 1st SEQ ID Conservancy Frequency Protein Pos Sequence P2 C-term Peptide Filed A*0101 NO: 80 16 ENV 119 AMQWNSTTF M F 1749 90 18 POL 737 DNSVVLSRKY N Y 20.0255 0.0001 1750 95 19 POL 631 FAAPFTQCGY A Y 20.0254 * 0.0680 1751 85 17 POL 590 GYSLNFMGY Y Y 2.0058 1752 100 20 POL 149 HTLWKAGILY T Y 1069.04 * 0.1100 1753 95 19 POL 653 KQAFTFSPTY Q Y 20.0256 0.0001 1754 85 17 NUC 30 LLDTASALY L Y 1069.01 * 12.0000 1755 95 19 POL 415 LSLDVSAAFY S Y 1090.07 * 0.0150 1756 85 17 ENV 360 MMWYWGPSLY M Y 1039.01 * 0.0810 1757 75 15 X 103 MSTTDLEAY S Y 2.0126 * 0.8500 1758 90 18 POL 738 NSVVLSRKY S Y 2.0123 0.0005 1759 100 20 POL 124 PLDKGIKPY L Y 1147.12 * 1760 100 20 POL 124 PLDKGIKPYY L Y 1069.03 * 0.1700 1761 85 17 POL 797 PTTGRTSLY T Y 1090.09 * 0.2100 1762 100 20 POL 165 SASFCGSPY A Y 1763 95 19 POL 416 SLDVSAAFY L Y 1069.02 * 5.2000 1764 16

TABLE-US-00017 TABLE XVI HBV A03 and A11 Motif (With binding information) Conser- Fre- 1st Super C- SEQ ID vancy quency Protein Pos Sequence Motif Motif P2 term Peptide Filed A*0301 A*1101 NO: 85 17 POL 721 AACFARSR A03/A11 A03 A R 26.0003 0.0004 0.0003 1785 95 19 POL 643 AAPFTQCGY A03/A11 A03 A Y 1766 95 19 POL 540 AFPHCLAFSY A03/A11 A03 F Y 1767 95 19 X 62 AFSSAGPCA A03/A11 A03 F A 1768 95 19 POL 666 AFTFSPTYK A03/A11 A03 F K 20.0130 * 0.2600 0.0400 1769 95 19 POL 666 AFTFSPTYKA A03/A11 A03 F A 1770 95 19 POL 18 AGPLEEEPR A03/A11 A03 G R 20.0265 0.0004 0.0002 1771 95 19 POL 521 AICSVVRR A03/A11 A03 I R 26.0004 -0.0002 0.0003 1772 95 19 POL 532 AICSVVRRAF A03/A11 A03 I F 1773 90 18 POL 772 ALNPADDPSR A03/A11 A03 L R 1.1090 0.0003 0.0001 1774 85 17 X 70 ALRFTSAR A03/A11 A03 L R 26.0005 0.0047 0.0009 1775 80 16 ENV 119 AMQWNSTTF A03/A11 A03 M F 1776 80 16 ENV 119 AMQWNSTTF A03/ A03 M F 1777 80 16 ENV 119 AMQWNSTTFH A03/A11 A03 M H 1778 80 16 POL 822 ASPLHAWR A03/A11 A03 S R 1779 75 15 ENV 84 ASTNRQSGR A03/A11 A03 S R 1150.60 0.0009 0.0002 1780 80 16 POL 755 CAANWILR A03/A11 A03 A R 1781 85 17 X 69 CALRFTSAR A03/A11 A03 A R 26.0149 * 0.0034 0.0230 1782 85 17 POL 734 CFAPSRSGA A03/A11 A03 F A 1783 75 15 POL 618 CFPKLPVNR A03/A11 A03 F R 1784 95 19 POL 649 CGYPALMPLY A03/A11 A03 G Y 1785 100 20 ENV 323 CIPIPSSWAF A03/A11 A03 I F 1786 90 18 X 17 CLRPVGAESR A03/A11 A03 L P 1.1093 0.0011 0.0001 1787 75 15 ENV 239 CLRRFIIFLF A03/A11 A03 L F 1788 100 20 NUC 48 CSPHHTALR A03/A11 A03 S R 5.0055 * 0.0029 0.0001 1789 95 19 POL 534 CSVVRRAFPH A03/A11 A03 S H 1790 85 17 NUC 58 DLLDTASALY A03/A11 A03 L Y 1.0519 * 0.0001 0.0001 1791 85 17 NUC 29 DLLDTASALYR A03/A11 A03 L R 26.0530 0.0042 -0.0003 1792 95 19 ENV 207 DSWWTSLNF A03/A11 A03 S F 20.0120 0.0006 0.0002 1793 85 17 NUC 32 DTASALYR A03/A11 A03 T R 26.0006 0.0004 -0.0002 1794 95 19 POL 17 EAGPLEEELPR A03/A11 A03 A R 26.0531 -0.0009 -0.0003 1795 90 18 POL 718 ELLAACFAR A03/A11 A03 L R 1.0988 0.0002 0.0004 1796 85 17 POL 718 ELLAACFARSR A03/A11 A03 L R 26.0532 0.0062 0.0016 1797 95 19 NUC 43 ELLSFLPSDF A03/A11 A03 L F 1798 95 19 NUC 72 ESPEHCSPH A03/A11 A03 S H 1799 95 19 NUC 72 ESPEHCSPHH A03/A11 A03 S H 1800 95 19 NUC 174 ETTVVRRR A03/A11 A03 T R 26.0007 0.0003 -0.0002 1801 80 16 NUC 174 ETTVVRRRGR A03/A11 A03 T R 1.1073 0.0003 0.0001 1802 95 19 POL 642 FAAPFTQCGY A01/A03/ A03 A Y 20.0254 * 1803 80 16 POL 821 FASPLHVAWR A03/A11 A03 A R 1804 90 18 ENV 24 FFPDHQLDPA A03/A11 A03 F A 1805 75 15 NUC 139 FRRETVLEY A03/A11 A03 G Y 1806 75 15 POL 255 FGVEPSGSGH A03/A11 A03 G H 1807 80 16 ENV 248 FLLLICLIF A03/A11 A03 I F 1808 90 18 X 63 FSSAGPCALR A03/A11 A03 S R 1809 100 20 ENV 344 FSWLSUVPF A03/A11 A03 S F 20.0263 0.0004 0.0002 1810 95 19 POL 656 FTFSPTYK A03/A11 A03 T K 1147.19 * 0.0100 0.0100 1811 95 19 POL 667 FTFSPTYKAF A03/A11 A03 T F 20.0263 0.0004 0.0006 1812 95 19 POL 518 FTSAICSVVR A03/A11 A03 T R 1.1085 0.0003 0.0003 1813 95 19 POL 518 FTSAICSVVRR A03/A11 A03 T R 26.0533 0.0065 0.0092 1814 90 18 X 132 FVLGGCRHK A03/A11 A03 V K 1090.03 * 0.0430 0.0090 1815 80 16 POL 765 GCAANWILR A03/A11 A03 C R 1816 75 15 POL 567 GIHLNPNK A03/A11 A03 I K 1817 75 15 POL 567 GIHLNPNKTK A03/A11 A03 I K 1.0583 0.0025 0.0011 1818 75 15 POL 567 GIHLNPNKTKR A03/A11 A03 I R 1819 95 19 POL 638 GLLGFAAPF A03/A11 A03 L F 20.0124 0.0006 0.0002 1820 95 19 POL 520 GLSPFLLAQF A03/A11 A03 L F 1821 85 17 NUC 29 GMDIDPYK A03/AAA A03 M K 26.0009 0.0006 0.0004 1822 85 17 NUC 29 GMDIDPYKEF A03/A24 A03 M F 26.0372 -0.0003 -0.0002 1823 90 16 POL 735 GTDNSVVLSR A03/A11 A03 T R 1090.04 * 0.0010 0.0420 1824 90 18 POL 735 GTDNSVVLSRK A03/A11 A03 T K 1147.17 * 0.0140 0.5800 1825 80 16 POL 256 GVEPSGSGH A03/A11 A03 V H 1826 100 20 POL 372 GVFLVDKNPH A03/A11 A03 V H 1827 95 19 NUC 152 GVWIRTPPAY A03/A11 A03 V Y 1.0525 0.0047 0.0002 1828 95 19 NUC 123 GVWIRTPPAYR A03/A11 A03 V R 26.0535 * 0.1900 0.1700 1829 100 20 NUC 76 HCSPHHTALR A03/A11 A03 C R 1830 80 16 POL 831 HFASPLHVA A03/A11 A03 F A 1831 90 18 NUC 104 HISCLTFGR A03/A11 A03 I R 1069.18 * 0.0160 0.0065 1832 75 15 POL 569 HLNPNKTK A03/A11 A03 L K 1833 75 15 POL 569 HLNPNKTKR A03/A11 A03 L R 1.0983 0.0025 0.0001 1834 85 17 POL 726 HTAELLAACF A03/A11 A03 T F 1835 100 20 POL 149 HTLWKAGILYK A03/A11 A03 T K 1147.16 * 0.5400 0.4400 1836 95 19 POL 533 ICSVVRRAF A03/A11 A03 C F 1837 95 19 ENV 266 IFLLVLLDY A03/A11 A03 F Y 1838 80 16 POL 771 ILRGTSFVY A03/A11 A03 L Y 1.0205 * 0.0440 0.0002 1839 90 18 NUC 105 ISCLTFGR A03/A11 A03 S R 26.0010 0.0004 0.0002 1840 100 20 POL 153 KAGILYKR A03/A11 A03 A R 26.0011 0.0002 -0.0002 1841 75 15 POL 108 KLIMPARFY A03/A11 A03 L Y 1.0171 1842 80 16 POL 610 KLPVNRPIDWK A03/A11 A03 L K 1843 75 15 X 130 IWFVLGGCR A03/A11 A03 V R 1.0993 * 0.0420 0.0820 1844 75 15 X 130 KVFVLGGCRH A03/A11 A03 V H 1845 95 19 POL 55 KVGNFTGLY A03/A11 A03 V Y 1142.05 * 0.2100 0.0170 1846 85 17 POL 720 LAACFAASR A03/A11 A03 A R 20.0129 0.0058 0.0065 1847 100 20 POL 125 LDKGIKPYY A03/A11 A03 D Y 1848 95 19 ENV 206 LDSWWTSLNF A03/A11 A03 D F 1849 85 17 NUC 60 LDTASALYR A03/A11 A03 D R 26.0151 0.0004 -0.0002 1850 95 19 POL 428 LDVSAAFYH A03/A11 A03 D H 1851 80 16 ENV 247 LFILLLCLIF A03/A11 A03 F F 1852 80 16 ENV 247 LFILLLCLIF A03/A24 A03 F F 1853 80 16 POL 764 LGCAANWILR A03/A11 A03 G R 1854 75 15 POL 577 LGIHLNPNK A03/A11 A03 G K 1855 95 19 ENV 265 LIFLLVLLDY A03/A11 A03 I Y 1.0899 0.0022 0.0004 1856 90 18 POL 719 LLAACFAR A03/A11 A03 L R 26.0012 0.0024 0.0003 1857 85 17 POL 719 LLAACFARSR A03/A11 A03 L R 1858 85 17 NUC 30 LLDTASALVR A03/A11 A03 L R 1.1070 0.0050 0.0002 1859 80 16 POL 752 LLGCAANWILR A03/A11 A03 L R 1860 95 19 NUC 44 LLSFLPSDF A03/A11 A03 L F 1861 95 19 NUC 44 LLSFLPSDFF A03/A11 A03 L F 1862 95 19 ENV 175 LLVLQAGFF A03/A11 A03 L F 20.0121 0.0006 0.0002 1863 100 20 ENV 349 LLYPFVQWF A03/A11 A03 L F 1864 95 19 NUC 45 LSFLPSDFF A03/A11 A03 S F 20.0123 0.0006 0.0002 1865 95 19 POL 426 LSLDVSAAF A03/A11 A03 S F 1866 75 15 POL 564 LSLGIHLNPNK A03/A11 A03 S K 1867 95 19 X 53 LSLRGLPVCA A03/A11 A03 S A 1868 95 19 POL 521 LSPFLLAQF A03/A11 A03 S F 1869 95 19 NUC 169 LSTLPETTVVR A03/A11 A03 S R 26.0537 -0.0009 0.0008 1870 75 15 ENV 16 LSVPNPLGF A03/A11 A03 S F 1871 100 20 POL 423 LSWLSLDVSA A03/A11 A03 S A 20.0260 0.0048 0.0035 1872 75 15 POL 3 LSYQHFRK A03/A11 A03 S K 1873 85 17 POL 99 LTVNEKRR A03/A11 A03 T R 26.0013 -0.0002 -0.0002 1874 90 18 NUC 119 LVSFGVWIR A03/A11 A03 V R 1090.08 * 0.0028 0.0120 1875 100 20 POL 377 LVVDFSQFSR A03/A11 A03 V R 1069.20 * 0.0016 0.3600 1876 95 19 ENV 249 MCLRRFIIF A03/A11 A03 C F 1877 90 18 POL 550 MDDVVLGAK A03/A11 A03 D K 1878 90 18 NUC 30 MDIDPYKEF A03/A11 A03 D F 1879 85 17 ENV 360 MMWYWGPSLY A01/A03/ A03 M Y 1039.01 * 0.0500 0.0008 1880 75 15 X 103 MSTTDLEAYF A03/A11 A03 S F 1881 75 15 X 103 MSTTDLEAYFK A03/A11 A03 S K 1882 95 19 POL 572 NFLLSLGIH A03/A11 A03 F H 1883 90 18 NUC 75 NLEDPASR A03/A11 A03 L R 26.0014 -0.0002 -0.0002 1884 95 19 POL 45 NLNVSIPWTH A03/A11 A03 L H 1885 95 19 POL 45 NLNVSIPWTHK A03/A11 A03 L K 26.0538 -0.0009 0.0005 1886

75 15 ENV 15 NLSVPNPLGF A03/A11 A03 L F 1887 75 15 ENV 215 NSQSPTSNH A03/A11 A03 S H 1888 90 18 POL 738 NSVVLSRK A03/A11 A03 S K 26.0015 0.0006 0.0010 1889 100 20 POL 47 NVSIPWTHK A03/A11 A03 V K 1069.18 * 0.0820 0.0570 1890 90 18 POL 775 PADDPSRGR A03/A11 A03 A R 1150.35 0.0008 0.0002 1891 80 16 X 11 PARDVLCLR A03/A11 A03 A R 1150.36 0.0002 0.0002 1892 90 18 POL 366 PARVTGGVF A03/A11 A03 A F 1893 75 15 ENV 83 PASTNRQSGR A03/A11 A03 A R 1894 85 17 X 68 PCALRFTSAR A03/A11 A03 C R 1895 90 18 ENV 26 PDHQLDPAF A03/A11 A03 D F 1896 95 19 POL 523 PFLLAQFTSA A03/A11 A03 F A 1897 95 19 POL 645 PFTQCGYPA A03/A11 A03 F A 1898 100 20 ENV 244 PGYRWMCLR A03/A11 A03 G R 1.0964 0.0008 0.0005 1899 95 19 ENV 244 PGYRWMCLPR A03/A11 A03 G R 1.1068 0.0048 0.0001 1900 90 18 POL 616 PIDWKVCQR A03/A11 A03 I R 1.0985 0.0002 0.0005 1901 100 20 ENV 391 PIFFCLWVY A03/A11 A03 I Y 1.0843 0.0011 0.0002 1902 80 16 POL 496 PIILGFRK A03/A11 A03 I K 1903 95 19 POL 20 PLEEELPR A03/A11 A03 L R 26.0016 0.0002 -0.0002 1904 100 20 POL 438 PLHPAAMPH A03/A11 A03 L H 20.0128 0.0012 0.0002 1905 95 19 ENV 17 PLLVLQAGF A03/A11 A03 L F 1906 95 19 ENV 174 PLLVLQAGFF A03/A11 A03 L F 1907 100 20 POL 2 PLSYQHFR A03/A11 A03 L R 26.0017 -0.0002 -0.0002 1908 75 15 POL 2 PLSYQHFRK A03/A11 A03 L K 1.0161 0.0011 0.0031 1909 85 17 POL 98 PLTVNEKR A03/A11 A03 L R 26.0018 0.0002 -0.0002 1910 85 17 POL 98 PLTVNEKRR A03/A11 A03 L R 1.0974 0.0008 0.0005 1911 80 16 POL 516 PMGVGLSPF A03/A11 A03 M F 1912 80 16 POL 516 PMGVGLSPF A03/A24 A03 M F 1913 90 18 X 20 PVGAESRGR A03/A11 A03 V R 1.0990 0.0002 0.0005 1914 85 17 POL 612 PVNRPIDWK A03/A11 A03 V K 1142.06 * 0.0310 0.1400 1915 95 19 POL 865 QAFTFSPTY A03/A11 A03 A Y 20.0127 0.0030 0.0017 1916 95 19 POL 854 QAFTFSPTYK A03/A11 A03 A K 1090.10 * 0.0450 0.5400 1917 80 16 ENV 179 QAGFRLLTR A03/A11 A03 A R 1918 80 16 ENV 118 QAMQWNSTTF A03/A11 A03 A F 1919 75 15 NUC 189 QSPRRRRSQSR A03/AAA A03 S R 28.0839 1920 80 16 POL 189 QSSGILSR A03/A11 A03 S R 1921 95 19 POL 539 RAFPHCLAF A03/A11 A03 A F 20.0125 0.0015 0.0007 1922 75 15 POL 106 RLKLIMPAR A03/A11 A03 L R 1.0975 * 0.0950 0.0002 1923 75 15 POL 106 RLKLIMPARF A03/A11 A03 L F 1924 75 15 X 128 ALKVFVLGGCR A03/A11 A03 L R 1925 95 19 POL 387 ALVVDFSCF A03/A11 A03 L F 20.0122 0.0006 0.0002 1926 95 19 POL 376 RLVVDFSQFSR A03/A11 A03 L R 26.0539 * 0.2800 3.8000 1927 95 19 NUC 183 RSPRRRTPSPR A03/A11 A03 S R 26.0540 -0.0007 -0.0003 1928 75 15 NUC 167 RSQSPRRR A03/A11 A03 S R 1929 75 15 NUC 167 RSQSPRRRR A03/A11 A03 S R 1930 95 19 NUC 188 RTPSPRRR A03/A11 A03 T R 26.0019 -0.0002 -0.0002 1931 95 19 NUC 188 RTPSPRRRR A03/A11 A03 T R 1.0971 * 0.0054 0.0005 1932 80 16 POL 829 RVHFASPLH A03/A11 A03 V H 1933 100 20 POL 357 RVTGGVFLVDK A03/A11 A03 V K 1147.18 * 0.0190 0.0290 1934 90 18 X 65 SAGPCALR A03/A11 A03 A R 26.0020 -0.0002 0.0020 1935 90 18 X 65 SAGPCALRF A03/A11 A03 A F 26.0152 -0.0003 0.0004 1936 95 19 POL 520 SAICSVVR A03/A11 A03 A R 26.0021 -0.0002 0.0071 1937 95 19 POL 520 SAICSVVRR A03/A11 A03 A R 1090.11 * 0.0058 0.2100 1938 90 18 POL 771 SALNPADDPSR A03/A11 A03 A R 26.0542 -0.0004 -0.0003 1939 100 20 POL 165 SASFCGSPY A01/A03/ A03 A Y * 1940 75 15 POL 759 SFPWLLGCA A03/A11 A03 F A 1941 75 15 POL 759 SFPWLLGCAA A03/A11 A03 F A 1942 95 19 POL 427 SLDVSAAFYH A03/A11 A03 L H 1943 75 15 POL 565 SLGIHLNPNK A03/A11 A03 L K 28.0758 * 1944 100 20 ENV 348 SLLVPFVQWF A03/A11 A03 L F 1945 95 19 X 54 SLRGLPVCAF A03/A11 A03 L F 20.0259 0.0004 0.0002 1946 90 18 X 64 SSAGPCALR A03/A11 A03 S F 26.0153 * 0.0080 0.1400 1947 90 18 X 64 SSAGPCALRF A03/A11 A03 S F 26.0374 -0.0003 -0.0002 1948 95 19 NUC 170 STLPETTVVR A03/A11 A03 T R 1069.21 * 0.0007 0.0600 1949 95 19 NUC 170 STLPETTVVRR A03/A11 A03 T R 1083.01 0.0150 1.4000 1950 80 16 ENV 85 STNRQSGR A03/A11 A03 T R 1951 75 15 X 104 STTDLEAYF A03/A11 A03 T F 1952 75 15 X 104 STTDLEAYFK A03/A11 A03 T K 1.0584 * 0.0066 2.7000 1953 95 19 POL 535 SVVRRAFPH A03/A11 A03 V H 20.0131 * 0.1100 0.6100 1954 85 17 POL 727 TAELLAACF A03/A11 A03 A F 1955 85 17 POL 716 TAELLAACFAR A03/A11 A03 A R 28.0544 0.0006 0.0023 1956 90 18 POL 747 TDNSVVLSR A03/A11 A03 D R 1957 90 18 POL 747 TDNSVVLSRK A03/A11 A03 D K 20.0264 0.0006 0.0017 1958 75 15 NUC 138 TFGREIVLEY A03/A11 A03 F Y 1959 95 19 POL 668 TFSPTYKAF A03/A24 A03 F F 5.0064 1960 100 20 POL 370 TGGVFLVDK A03/A11 A03 G K 20.0133 0.0007 0.0061 1961 95 19 NUC 171 TLPETTVVR A03/A11 A03 L R 1.0969 0.0008 0.0002 1962 95 19 NUC 171 TLPETTVVRR A03/A11 A03 L R 1069.22 * 0.0007 0.0230 1963 95 19 NUC 171 TLPETTVVRRR A03/A11 A03 L R 26.0545 * 0.0005 0.0160 1964 100 20 POL 150 TLWKAGILY A03/A11 A03 L Y 1099.03 * 0.1300 0.0008 1965 100 20 POL 150 TLWKAGILYK A03/A11 A03 L K 1069.15 * 5.3000 0.3800 1966 100 20 POL 150 TLWKAGILYKR A03/A11 A03 L R 26.0546 0.0082 0.0095 1967 95 19 POL 519 TSAICSVVR A03/A11 A03 S R 5.0057 0.0005 0.0008 1968 95 19 POL 519 TSAICSVVRR A03/A11 A03 S R 1142.08 * 0.0018 0.0006 1969 75 15 POL 758 TSFPWLLGCA A03/A11 A03 S A 1970 80 16 POL 775 TSFVYVPSA A03/A11 A03 S A 1971 75 15 X 105 TTDLEAYFK A03/A11 A03 T K 1.0215 * 0.0006 0.9200 1972 75 15 ENV 278 TTSTGPCK A03/A11 A03 T K 1973 80 16 NUC 175 TTVVRRRGR A03/A11 A03 T R 1.0970 0.0008 0.0005 1974 80 16 NUC 176 TVVRRRGR A03/A11 A03 V R 3.0324 0.0003 0.0001 1975 80 16 NUC 176 TVVRRRGRSPR A03/A11 A03 V R 28.0837 1976 100 20 POL 373 VFLVDKNPH A03/A11 A03 F H 1977 80 16 X 131 VFVLGGCRH A03/A11 A03 F H 1978 75 15 X 131 VFVLGGCRH A03/A11 A03 F H 1979 95 19 POL 637 VGLLGFAAPF A03/A11 A03 G F 1980 85 17 POL 96 VGPLTVNEK A03/A11 A03 G K 20.0132 0.0007 0.0078 1981 85 17 POL 96 VGPLTVNEKR A03/A11 A03 G R 1982 95 19 POL 554 VLGAKSVQH A03/A11 A03 L H 1983 90 18 X 133 VLGGCRHK A03/A11 A03 L K 26.0022 0.0150 0.0002 1984 80 16 ENV 177 VLQAGFFLLTR A03/A11 A03 L R 1985 85 17 POL 752 VLSRKYTSF A03/A11 A03 S R 1986 90 18 NUC 120 VSFGVWIR A03/A11 A03 S R 26.0023 * 0.0040 0.0290 1987 100 20 POL 48 VSIPWTHK A03/A11 A03 S K 26.0024 * 0.0130 0.0170 1988 100 20 POL 358 VTGGVFLVDK A03/A11 A03 T K 1069.17 * 0.0390 0.0920 1989 100 20 POL 378 VVDFSQFSR A03/A11 A03 V R 1069.19 * 0.0015 0.0750 1990 90 18 POL 553 VVLGAKSVQH A03/A11 A03 V H 1991 85 17 POL 751 VVLSRKYTSF A03/A11 A03 V F 20.0261 0.0004 0.0002 1992 80 16 NUC 177 VVRRRGRSPR A03/A11 A03 V R 1.1074 0.0027 0.0001 1993 80 16 NUC 177 VVRRRGRSPRR A03/A11 A03 V R 28.0838 1994 90 18 NUC 131 WFHISCLTF A03/A11 A03 F F 13.0073 * 1995 90 18 NUC 131 WFHISCLTF A03/A24 A03 F F 13.0073 * 1996 85 17 NUC 28 WGMDIDPYK A03/A11 A03 G K 26.0154 -0.0003 0.0006 1997 85 17 POL 589 WGYSLNFMGY A03/A11 A03 G Y 1998 80 16 POL 770 WLRGTSFVY A03/A11 A03 I Y 1.0572 0.0076 0.0011 1999 95 19 NUC 125 WIRTPPAYR A03/A11 A03 I R 1.0968 0.0008 0.0005 2000 90 18 POL 314 WLQFRNSK A03/A11 A03 L K 26.0025 -0.0002 0.0005 2001 95 19 POL 425 WLSLDVSAAF A03/A11 A03 L F 2002 85 17 NUC 26 WLWGMDIDPY A03/A11 A03 L Y 1.0774 * 0.0002 0.0002 2003 85 17 NUC 26 WLWGMDIDPYK A03/A11 A03 L K 26.0547 0.0030 0.0013 2004 95 19 ENV 248 WMCLRRFIIF A03/A11 A03 M F 20.0266 0.0004 0.0011 2005 95 19 ENV 248 WMCLRRFIIF A03/A24 A03 M F 20.0266 0.0004 0.0011 2006 100 20 POL 122 YLPLDKGIIK A03/A11 A03 L K 1.0173 0.0001 0.0001 2007 90 18 NUC 118 YLVSFGVWIR A03/A11 A03 L R 1090.13 * 0.0005 0.0002 2008 90 18 POL 538 YMDDVVLGAK A03/A11 A03 M K 1090.15 * 0.0330 0.0043 2009 80 16 POL 504 YSHPIILGF A03/A11 A03 S F 2010 80 16 POL 493 YSHPIILGFR A03/A11 A03 S R 2011

80 16 POL 493 YSHPIIGFRK A03/A11 A03 S K 2012 248

TABLE-US-00018 TABLE XVII HBV A24 Motif With Binding Information SEQ ID Conservancy Frequency Protein Position Sequence P2 C-term Peptide Filed A*2401 NO: 95 19 X 62 AFSSAGPCAL F L 5.0118 0.0012 2013 90 18 POL 535 AFSYMDDVVL F L 13.0130 0.0009 2014 80 16 ENV 108 AMQWNSTTF M F 2015 100 20 NUC 131 AYRPPNAPI Y I 1090.02 * 0.0310 2016 100 20 NUC 131 AYRPPNAPIL Y L 1069.24 * 0.0042 2017 90 18 NUC 117 EYLVSFGVW Y W 26.0150 2018 90 18 NUC 117 EYLVSFGVWI Y I 17.0428 * 2019 80 16 ENV 182 FFLLTRILTI F I 2020 80 16 ENV 181 GFFLLTRIL F L 2021 75 15 ENV 170 GFLGPLLVL F L 2022 85 17 NUC 29 GMDIDPYKEF M F 26.0372 2023 85 17 ENV 65 GWSPQAQGI W I 20.0134 0.0024 2024 85 17 ENV 65 GWSPQAQGIL W L 20.0266 0.0003 2025 95 19 ENV 234 GYRWMCLRRF Y F 1069.25 * 0.0007 2026 80 16 POL 820 HFASPLHVAW F W 2027 100 20 ENV 381 IFFCLWVYI F I 5.0058 0.0087 2028 80 16 ENV 245 IFLFILLLCL F L 2029 95 19 POL 395 KFAVPNLQSL F L 5.0114 0.0020 2030 100 20 POL 121 KYLPLDKGI Y I 2031 85 17 POL 745 KYTSFPWLL Y L 1069.23 * 5.3000 2032 80 16 ENV 247 LFILLLCLI F I 2033 80 16 ENV 247 LFILLLCLIF F F 2034 85 17 NUC 101 LWFHISCLTF W F 26.0373 2035 80 16 POL 492 LYSHPIILGF Y F 2.0181 * 1.1000 2036 95 19 POL 561 NFLLSLGIHL F L 5.0115 0.0099 2037 80 16 POL 758 NWILRGTSF W F 2035 95 19 POL 634 PFTQCGYPAL F L 5.0116 0.0002 2039 95 19 ENV 341 PFVQWFVGL F L 5.0059 0.0003 2040 80 16 POL 505 PMGVGLSPF M F 2041 80 16 POL 750 PWLLGCAANW W W 2042 100 20 POL 51 PWTHKVGNF W F 20.0138 * 0.0290 2043 75 15 ENV 242 RFIIFLFIL F L 2044 75 15 ENV 242 RF1IFLFILL F L 2045 95 19 ENV 236 RWMCLRRFI W I 20.0135 * 0.0710 2046 95 19 ENV 236 RWMCLRRFII W I 20.0269 * 1.1000 2047 100 20 POL 167 SFCGSPYSW F W 20.0139 * 0.0710 2048 80 16 POL 765 SFVYVPSAL F L 2049 100 20 ENV 334 SWLSLLVPF W F 20.0136 * 0.3900 2050 95 19 POL 392 SWPKFAVPNL W L 20.0271 * 5.6000 2051 95 19 ENV 197 SWWTSLNFL W L 20.0137 * 0.3800 2052 75 15 POL 4 SYQHFRKLL Y L 2.0042 0.0051 2053 75 15 POL 4 SYQHFRKLLL Y L 2.0173 * 0.0680 2054 95 19 POL 657 TFSPTYKAF F F 5.0064 0.0060 2055 95 19 POL 657 TFSPTVKAFL F L 5.0117 0.0043 2056 95 19 POL 686 VFADATPTGW F W 20.0272 * 0.0180 2057 90 18 NUC 102 WFHISCLTF F F 13.0073 * 0.0300 2058 95 19 ENV 345 WFVGLSPTVW F W 20.0270 0.0120 2059 95 19 env 237 WMCLRAFIIF M F 20.0266 0.0013 2060 48

TABLE-US-00019 TABLE XVIII DR SUPER MOTIF (With binding information) SEQ ID NO: Sequence Peptide DR1 DR2w2B1 DR2w2B1 DR3 DR4w4 Dr4w15 2061 AANWILRGTSFVYVP 1298.07 0.0920 0.0240 0.0061 0.0023 0.0510 0.0250 2062 AEDLNLGNLNVSIPW 1186.01 0.0001 -0.0005 -0.0007 2063 AELLAACFARSRSGA 2064 AFSYMDDVVLGAKSV 1186.02 0.0027 -0.0005 0.0130 2.9000 2065 AGFFLLTRILTIPQS 1280.06 4.6000 0.0420 0.0190 0.0040 5.3000 0.1500 2066 AGPLEEELPRLADEG 35.0091 0.0022 2067 AKLIGTDNSVVLSRK 2068 ANWILRGTSFVYVPS 2069 ARDVLCLRPVGAESR 2070 ASALYREALESPEHC 2071 ASKLCLGWLWGMDID 1186.03 0.0002 -0.0005 0.0017 2072 CLIFLLVLLDYQGML 2073 CLTFGRETVLEYLVS 2074 CPGYRWMCLRRFIIF 2075 CPTVQASKLCLGWLW 2076 CQVFADATPTGWGLA 2077 CSVVRRAFPHCLAFS 1186.04 0.1000 0.1024 0.0770 0.0032 0.0016 -0.0022 2078 CTCIPIPSSWAFARF 2079 CWWLQFRNSKPCSDY 2080 DDVVLGAKSVQHLES 2081 DEGLNRRVAEDLNLG 2082 DLNLGNLNVSIPWTH 1280.07 0.0038 0.0240 2083 DVVLGAKSVQHLESL 2084 DWKVCQRIVGLLGFA 1186.05 0.0120 -0.0026 0.0030 2085 EIRLKVFVLGGCRHK 2086 ESRLVVDFSQFSRGN 35.0096 0.0007 2.6000 2087 FFLLTRILTIPQSLD F064.01 2088 FGVWIRTPPAYRPPN 2089 FIIFLFILLLCLIFL 2090 FLFILLLCLIFLLVL 2091 FPWLLGCAANWILRG 2092 FRKLPVNRPIDWKVC 2093 FSWLSLLVPFVQWFV 2094 FSYMDDVVLGAKSVQ 2095 FVQWFVGLSPTVWLS 1186.06 0.4700 0.0035 0.0610 -0.0013 0.0130 2096 GAHLSLRGLPVCAFS 1186.07 0.7800 0.0042 -0.0041 0.0011 2097 GFFLLTRILTIPQSL 1280.08 0.4300 0.0150 0.0110 3.1000 0.4500 2098 GIHLNPNKTKRWGYS 2099 GLPVCAFSSAGPCAL 2100 GLYFPAGGSSSGTVN 2101 GTNLSVPNPLGFFPD 2102 GTSFVYVPSALNPAD 1280.09 0.3500 0.0140 0.0500 -0.0006 0.3800 0.4100 2103 GVFLVDKNPHNTTES 2104 GVGLSPFLLAQFTSA 2105 GVWIRTPPAYRPPNA 27.0280 0.3700 0.0420 7.2000 0.0120 3.4000 0.5700 2106 HGGLLGWSPQAQGIL 2107 HLPLHPAAMPHLLVG 2108 HLSLRGLPVCAFSSA 1280.10 1.3000 0.0028 2109 HTALRQAILCWGELM 2110 HTLWKAGILYKRETT 2111 IFLFILLLCLIFLLV 1280.11 0.0005 0.0041 2112 IIFLFILLLCLIFLL 1280.12 2113 ILGFRKIPMGVGSLP 2114 ILLLCLIFLLVLLDY F107.01 0.0026 0.0069 0.0320 2115 IRDLLDTASALYREA 2116 IRQLLWFHISCLTFG 2117 IVGLLGFAAPFTQCG 1186.09 0.0200 -0.0005 -0.0007 2118 IWMMWYWGPSLYNIL 2119 KFAVPNLQSLTNLLS 1280.13 0.0180 0.0005 -0.0003 0.1300 2120 KIPMGVGLSPFLLAQ 2121 KLHLYSHPIILGFRK 2122 KQAFTFSPTYKAFLC 1298.06 0.5300 0.2400 0.1400 0.0090 1.1000 0.2200 2123 KQCFRKLPVNRPIDW 1298.04 1.5000 0.0022 0.0210 -0.0006 1.2000 0.8500 2124 KRRLKLIMPARFYPN 2125 LAQFTSAICSVVRRA 1186.10 0.0120 0.0065 0.1500 -0.0009 0.0150 0.0280 2126 LCLIFLLVLLDYQGM F107.02 0.0016 0.0060 0.0230 2127 LCQVFADATPTGWGL 1280.14 0.0020 0.9600 2128 LEYLVSFGVWIRTPP 2129 LFILLLCLIFLLVLL 2130 LGFFPDHQLDPAFGA 2131 LGNLNVSIPWTHKVG 2132 LGPLLVLQAGFFLLT 2133 LGWLWGMDIDPYKEF 1186.12 0.0004 0.0006 0.0200 0.0280 2134 LHLYSHPIILGFRKI 1280.16 0.0220 0.0340 0.0400 0.0040 0.6800 2135 LHTLWKAGILYKRET 2136 LKVFVLGGCRHKLVC 2137 LLCLIFLLVLLDYQG 1280.16 2138 LLDYQGMLPVCPLIP 2139 LLGFAAPFTQCGYPA 2140 LLWFHISCLTFGRET 2141 LPKVLHKRTLGLSAM 2142 LPLLPIFFCLWVYIZ 2143 LQSLTNLLSSNLSWL F107.03 2.5000 0.4400 0.0200 -0.0013 4.8000 2144 LSAMSTTDLEAYFKD 2145 LSTLPETTVVRRRGR 2146 LSWLSLDVSAAFYHI 2147 LTNLLSSNLSWLSLD 1186.14 0.0010 0.0083 0.0160 2148 LVLLDYQGMLPVCPL 1280.17 0.0034 -0.0013 2149 LVPFVQWFVGLSPTV 1186.15 0.0130 0.6900 0.0140 -0.0013 0.1500 2150 MQLFHLCLIISCSCP 2151 NAPILSTLPETTVVR 1186.16 0.0009 0.0009 -0.0007 2152 NLNVSIPWTHKVGNF 1186.17 0.0001 -0.0005 -0.0041 -0.0007 2153 NLSWLSLDVSAAFYH 1186.18 0.1400 0.0003 -0.0005 1.3000 0.2900 2154 NRPIDWKVCQRIVGL 2155 PAAMPHLLVGSSGLS 2156 PDRVHFASPLHVAWR 1298.08 0.0510 0.0290 0.0008 0.0008 2157 PFLLAQFTSAICSVV F107.04 0.1800 0.0270 0.0042 -0.0013 0.0800 2158 PHCLAFSYMDDVVLG 2159 PIILGFRKIPMGVGL 2160 PLPIHTAELLAACFA 1280.18 0.0046 0.0490 2161 PPAYRPPNAPILSTL 1186.20 0.0056 -0.0005 0.0038 2162 PQAMQWNSTTFHQTL 1298.01 0.0012 0.0300 2163 PQSLDSWWTSLNFLG 2164 QCGYPALMPLYACIQ 1186.21 0.0062 0.0018 0.0068 2165 QLLWFHISCLTFGRE 2166 QQYVGPLTVNEKRRL 2167 QWFVGLSPTVWLSVI 2168 RDLLDTASALYREAL 1280.19 0.0001 0.0092 2169 RDVLCLRPVGAESRG 2170 RFIIFLFILLLCLIF 2171 RFSWLSLLVPFVQWF 1186.22 0.0430 0.0008 -0.0007 2172 RPGLCQVFADATPTG 2173 RQLLWFHISCLTFGR 1186.23 0.0002 0.0009 0.0140 2174 RRAFPHCLAFSYMDD F107.05 0.0010 0.0010 -0.0009 2175 RRFIIFLFILLLCLI 2176 RRSFGVEPSGSGHID 2177 RVSWPKFAVPNLQSL 2178 RWGYSLNFMGYVIGS 2179 SFGVWIRTPPAYRPP 1186.25 0.0094 0.0110 0.4300 -0.0009 0.0780 0.0630 2180 SFPWLLGCAANWILR 2181 SFVYVPSALNPADDP

2182 SGFLGPLLVLQAGFF 2183 SPFLLAQFTSAICSV 1186.26 0.1200 0.0200 0.0085 -0.0013 0.0740 0.0190 2184 SSNLSWLSLDVSAAF 1186.27 0.1400 0.0030 -0.005 1.5000 0.2700 2185 SVELLSFLPSDFFPS 2186 SVRFSWLSLLVPFVQ 1280.20 0.9000 0.0099 2187 SVVLSRKYTSFPWLL 27.0282 0.0005 0.0057 0.2100 -0.0016 2188 TNFLLSLGIHLNPNK 1298.03 3.5000 0.0410 0.1200 0.0220 0.0360 2189 TNLLSSNLSWLSLDV 1186.28 0.0016 -0.0005 0.1300 2190 TRILTIPQSLDSWWT 2191 TSFVYVPSALNPADD 2192 TSGFLGPLLVLQAGF 2193 VAPLPIHTAELLAAC 2194 VCAFSSAGPCALRFT 1186.29 0.2100 0.2600 0.0023 2195 VELLSFLPSDFFPSI 2196 VGLLGFAAPFTQCGY 1280.21 0.0470 0.3100 0.008 -0.0014 2197 VGNFTGLYSSTVPVF 1298.02 1.7000 0.0100 0.0016 0.0140 0.1700 2198 VLCLRPVGAESRGRP 2199 VQWFVGLSPTVWLSV 2200 WASVRFSWLSLLVPF 2201 WLSLDVSAAFYHIPL 2202 WLSLLVPFVQWFVGL 2203 WMCLRRFIIFLFILL 2204 WPKFAVPNLQSLTNL 1186.30 0.0007 0.0013 0.0023 2205 YPALMPLYACIQSKQ 1298.05 0.2400 0.0014 SEQ ID NO: Sequence DR5w11 DR5w12 DR6w19 DR7 DR8w2 DR9 DRW53 2061 AANWILRGTSFVYVP 0.0140 0.3700 0.0250 0.5800 0.2500 0.2700 2062 AEDLNLGNLNVSIPW -0.0002 -0.0003 0.0170 2063 AELLAACFARSRSGA 2064 AFSYMDDVVLGAKSV 0.0006 -0.0003 -0.0005 2065 AGFFLLTRILTIPQS 3.6000 0.0700 0.3700 3.1000 0.2600 1.3000 2066 AGPLEEELPRLADEG 2067 AKLIGTDNSVVLSRK 2068 ANWILRGTSFVYVPS 2069 ARDVLCLRPVGAESR 2070 ASALYREALESPEHC 2071 ASKLCLGWLWGMDID -0.0002 0.0013 0.0010 2072 CLIFLLVLLDYQGML 2073 CLTFGRETVLEYLVS 2074 CPGYRWMCLRRFIIF 2075 CPTVQASKLCLGWLW 2076 CQVFADATPTGWGLA 2077 CSVVRRAFPHCLAFS 0.0008 -0.0013 0.0540 0.0590 0.0250 1.2000 0.0460 2078 CTCIPIPSSWAFARF 2079 CWWLQFRNSKPCSDY 2080 DDVVLGAKSVQHLES 2081 DEGLNRRVAEDLNLG 2082 DLNLGNLNVSIPWTH 0.0010 2083 DVVLGAKSVQHLESL 2084 DWKVCQRIVGLLGFA 0.2500 0.0018 0.0130 2085 EIRLKVFVLGGCRHK 2086 ESRLVVDFSQFSRGN 2087 FFLLTRILTIPQSLD 2088 FGVWIRTPPAYRPPN 2089 FIIFLFILLLCLIFL 2090 FLFILLLCLIFLLVL 2091 FPWLLGCAANWILRG 2092 FRKLPVNRPIDWKVC 2093 FSWLSLLVPFVQWFV 2094 FSYMDDVVLGAKSVQ 2095 FVQWFVGLSPTVWLS 0.0072 0.0021 0.0190 0.0690 0.0180 0.0410 0.0044 2096 GAHLSLRGLPVCAFS 0.0025 0.0077 0.0150 2097 GFFLLTRILTIPQSL 2.3000 0.0780 3.5000 1.6000 0.5500 2098 GIHLNPNKTKRWGYS 2099 GLPVCAFSSAGPCAL 2100 GLYFPAGGSSSGTVN 2101 GTNLSVPNPLGFFPD 2102 GTSFVYVPSALNPAD 0.0470 -0.0001 0.0001 0.2700 0.0610 0.3400 2103 GVFLVDKNPHNTTES 2104 GVGLSPFLLAQFTSA 2105 GVWIRTPPAYRPPNA 0.4800 0.0140 -0.0004 0.2200 0.5300 0.0450 2106 HGGLLGWSPQAQGIL 2107 HLPLHPAAMPHLLVG 2108 HLSLRGLPVCAFSSA 0.0130 2109 HTALRQAILCWGELM 2110 HTLWKAGILYKRETT 2111 IFLFILLLCLIFLLV 0.0018 2112 IIFLFILLLCLIFLL 2113 ILGFRKIPMGVGSLP 2114 ILLLCLIFLLVLLDY 0.0018 0.0047 2115 IRDLLDTASALYREA 2116 IRQLLWFHISCLTFG 2117 IVGLLGFAAPFTQCG -0.0002 0.0009 0.0087 2118 IWMMWYWGPSLYNIL 2119 KFAVPNLQSLTNLLS 0.0043 0.0088 -0.0003 0.0056 2120 KIPMGVGLSPFLLAQ 2121 KLHLYSHPIILGFRK 2122 KQAFTFSPTYKAFLC 0.2400 0.0024 0.0200 0.3300 0.1200 0.5400 2123 KQCFRKLPVNRPIDW 0.0130 0.0013 0.0043 0.4000 0.0580 0.0250 2124 KRRLKLIMPARFYPN 2125 LAQFTSAICSVVRRA 0.0076 0.0091 0.0010 0.0280 0.0150 0.0880 0.0190 2126 LCLIFLLVLLDYQGM 0.0017 0.0044 2127 LCQVFADATPTGWGL 0.0013 2128 LEYLVSFGVWIRTPP 2129 LFILLLCLIFLLVLL 2130 LGFFPDHQLDPAFGA 2131 LGNLNVSIPWTHKVG 2132 LGPLLVLQAGFFLLT 2133 LGWLWGMDIDPYKEF -0.0002 0.0004 0.0430 2134 LHLYSHPIILGFRKI 0.0410 0.0310 0.0002 0.0006 0.0610 0.0490 2135 LHTLWKAGILYKRET 2136 LKVFVLGGCRHKLVC 2137 LLCLIFLLVLLDYQG 2138 LLDYQGMLPVCPLIP 2139 LLGFAAPFTQCGYPA 2140 LLWFHISCLTFGRET 2141 LPKVLHKRTLGLSAM 2142 LPLLPIFFCLWVYIZ 2143 LQSLTNLLSSNLSWL 0.0680 0.7500 0.0260 0.1500 0.0880 0.1100 2144 LSAMSTTDLEAYFKD 2145 LSTLPETTVVRRRGR 2146 LSWLSLDVSAAFYHI 2147 LTNLLSSNLSWLSLD 0.0013 0.0019 0.0200 2148 LVLLDYQGMLPVCPL 0.0011 2149 LVPFVQWFVGLSPTV 0.3800 0.6600 0.0018 0.0092 0.6600 2.5000 2.6000 2150 MQLFHLCLIISCSCP 2151 NAPILSTLPETTVVR -0.0002 0.0005 0.1600 2152 NLNVSIPWTHKVGNF -0.0002 0.0005 0.0009 2153 NLSWLSLDVSAAFYH 0.0033 0.0022 0.0330 0.0041 0.0150 0.0820 2.4000 2154 NRPIDWKVCQRIVGL 2155 PAAMPHLLVGSSGLS 2156 PDRVHFASPLHVAWR 0.0008 0.0190 0.0810 0.0035 0.2400 2157 PFLLAQFTSAICSVV 0.0120 0.0016 0.0800 0.0770 0.0680 0.0590 2158 PHCLAFSYMDDVVLG 2159 PIILGFRKIPMGVGL 2160 PLPIHTAELLAACFA -0.0003

2161 PPAYRPPNAPILSTL 0.0022 0.0024 0.0015 2162 PQAMQWNSTTFHQTL 0.1200 2163 PQSLDSWWTSLNFLG 2164 QCGYPALMPLYACIQ 0.0023 0.0006 2165 QLLWFHISCLTFGRE 2166 QQYVGPLTVNEKRRL 2167 QWFVGLSPTVWLSVI 2168 RDLLDTASALYREAL 0.0770 2169 RDVLCLRPVGAESRG 2170 RFIIFLFILLLCLIF 2171 RFSWLSLLVPFVQWF 0.0002 0.0005 0.0031 2172 RPGLCQVFADATPTG 2173 RQLLWFHISCLTFGR 0.0011 0.0061 0.0098 2174 RRAFPHCLAFSYMDD 0.0010 0.0017 2175 RRFIIFLFILLLCLI 2176 RRSFGVEPSGSGHID 2177 RVSWPKFAVPNLQSL 2178 RWGYSLNFMGYVIGS 2179 SFGVWIRTPPAYRPP 0.0260 0.0071 0.0002 0.0240 0.2500 0.2800 0.0016 2180 SFPWLLGCAANWILR 2181 SFVYVPSALNPADDP 2182 SGFLGPLLVLQAGFF 2183 SPFLLAQFTSAICSV -0.0002 -0.0013 0.0540 0.0330 0.0014 0.0380 0.2000 2184 SSNLSWLSLDVSAAF 0.0046 0.0180 0.1000 0.0038 0.0460 0.0110 6.2000 2185 SVELLSFLPSDFFPS 2186 SVRFSWLSLLVPFVQ 0.0037 2187 SVVLSRKYTSFPWLL 0.5300 0.0130 2188 TNFLLSLGIHLNPNK 0.0053 0.0160 0.2200 0.0032 0.3800 2189 TNLLSSNLSWLSLDV 0.0006 0.0019 0.0410 2190 TRILTIPQSLDSWWT 2191 TSFVYVPSALNPADD 2192 TSGFLGPLLVLQAGF 2193 VAPLPIHTAELLAAC 2194 VCAFSSAGPCALRFT 0.0003 0.0200 0.0150 2195 VELLSFLPSDFFPSI 2196 VGLLGFAAPFTQCGY -0.0004 -0.0001 0.0014 0.5700 2197 VGNFTGLYSSTVPVF 0.0035 0.0580 0.5600 0.0044 0.3100 2198 VLCLRPVGAESRGRP 2199 VQWFVGLSPTVWLSV 2200 WASVRFSWLSLLVPF 2201 WLSLDVSAAFYHIPL 2202 WLSLLVPFVQWFVGL 2203 WMCLRRFIIFLFILL 2204 WPKFAVPNLQSLTNL 0.0002 0.0008 0.0180 2205 YPALMPLYACIQSKQ 0.0011 145

TABLE-US-00020 TABLE XIX HBV DR3 MOTIF PEPTIDES WITH BINDING DATA Total Core Con- Con- Core SEQ Binding ser- ser- Core Pro- Posi- Core SEQ ID ID Data Mo- vancy Total vancy Freq. tein tion Sequence NO: Sequence NO: Peptide Filed DR3 tif 90.00 18 90.00 18 POL 535 YMDDWLGA 2228 AFSYMDDVVLGAKSV 2206 1186.02 0.0130 DR3 55.00 11 95.00 19 POL 655 PSPTYKAFL 2229 AFTFSPTYKAFLCKQ 2207 35.0099 0.0035 DR3 65.00 13 90.00 18 POL 18 LEEELPRLA 2230 AGPLEEELPRLADEG 2208 35.0091 0.0022 DR3 65.00 13 80.00 16 POL 731 IGTDNSVVL 2231 AKLIGTDNSVVLSRK 2209 DR3 85.00 17 85.00 17 NUC 34 LYREALESP 2232 ASALYREALESPEHC 2210 DR3 70.00 14 75.00 15 NUC 136 RGRETVLEY 2233 CLTFGRETVLEYLVS 2211 DR3 90.00 18 90.00 18 X 48 AHLSLRGLP 2234 DHGAHLSLRGLPVCA 2212 DR3 85.00 17 90.00 18 POL 737 VVLSRKYTS 2235 DNSVVLSRKYTSFPW 2213 DR3 45.00 9 100.00 20 POL 374 LVVDFSQFS 2236 ESRLVVDFSQFSRGN 2214 35.0096 * 2.6000 DR3 5.00 1 75.00 1 ENV 172 AVLDPRVRG 2237 FHQAVLDPRVRGLYL 2215 DR3 90.00 18 95.00 19 ENV 256 VLLDYQGML 2238 FLLVLLDYQGMLPVC 2216 35.009 0.0170 DR3 55.00 11 100.00 20 POL 360 FLVDKNPHN 2239 GGVFLVDKNPHNTTE 2217 35.0095 0.0790 DR3 95.00 19 95.00 19 POL 683 VFADATPTG 2240 LCQVFADATPTGWGL 2218 1280.14 0.0000 DR3 35.00 7 95.00 19 X 18 VGAESRGRP 2241 LRPVGAESRGRPVSG 2219 35.0101 -0.0017 DR3 55.00 11 95.00 19 POL 412 LSLDVSAAF 2242 LSWLSLDVSAAFYHI 2220 DR3 45.00 9 85.00 17 NUC 27 MDIDPYKEF 2243 LWGMDIDPYKEFGAS 2221 DR3 85.00 17 100.00 20 POL 34 VAEDLNLGN 2244 NRRVAEDLNLGNLNV 2222 35.0092 0.1400 DR3 100.00 20 100.00 20 POL 47 IPWTHKVGN 2245 NVSIPWTHKVGNFTG 2223 DR3 45.00 9 95.00 19 ENV 10 FFPDHQLDP 2246 PLGFFPDHQLDPAFG 2224 DR3 30.00 6 75.00 15 POL 241 PGVEPSGSG 2247 RRSFGVEPSGSGHID 2225 DR3 100.00 20 100.00 20 POL 120 LPLDKGIKP 2248 TKYLPLDKGIKPYYP 2226 35.0084 -0.0017 DR3 60.00 12 85.00 17 POL 96 LTVNEKRRL 2249 VGPCTVNEKRRLKLI 2227 35.0093 * 2.2000 DR3 22 22

TABLE-US-00021 TABLE XX Population coverage with combined HLA Supertypes PHENOTYPIC FREQUENCY N.A. HLA-SUPERTYPES Caucasian Black Japanese Chinese Hispanic Average A2, A3, B7 83.0 86.1 87.5 88.4 86.3 86.2 A2, A3, B7, A24, B44, A1 99.5 98.1 100.0 99.5 99.4 99.3 A2, A3, B7, A24, B44, A1, 99.9 99.6 100.0 99.8 99.9 99.8 B27, B62, B58

TABLE-US-00022 TABLE XXI HBV ANALOGS A2 A3 B7 1* Fixed A1 Super Super A24 Super Anchor SEQ ID AA Sequence Nomen. Motif Motif Motif Motif Motif Fixer Analog NO: ALFKDWEEL 2250 9 ALMPLYACV L2.IV9 N Y N N N 1 A 2251 ALMPLYASI 2252 9 ALMPLYAXI N Y N N N A 2253 10 ALPSDFFPSV N Y N N N No A 2254 ALPSDFFPSV-NH2 2255 ALSLIVNLL 2256 9 AMTFSPTYK N N Y N N A 2257 ATVELLSFLPSDFFPSV-NH2 2258 10 CILLLCLIFL N Y N N N No A 2259 11 CILLLCLIFLL N Y N N N No A 2260 9 DPFRGRLGL N N N N N A 2261 9 DPSRGRLGI N N N N Y A 2262 ELLSFLPSDFFPSV-NH2 2263 10 FAPSDFFPSV LA2.V10 N Y N N N Rev A 2264 10 FILLLXLIFL N Y N N N A 2265 10 FLASDFPPSV N Y N N N No A 2266 10 FLGLSPTVWV VL2.LV1 N Y N N N 1 A 2267 10 FLKSDFPPSV N Y N N N No A 2268 10 FLLAQFTSAV L2.IV10 N Y N N N 1 A 2269 9 FLLAQFTSV L2.AV9 N Y N N N 1 A 2270 9 FLLPIFFCL N Y N N N No A 2271 9 FLLSLGIHV L2.LV9 N Y N N N 1 A 2272 9 FLLTRILTV L2.IV9 N Y N N N 1 A 2273 9 FLLTRILYI N Y N N N A 2274 9 FLLTYILTI N Y N N N A 2275 10 FLMSDYFPSV N Y N N N No A 2276 9 FLMSYFPSV N Y N N N No A 2277 10 FLPADFFPSI L2.SA4 N Y N N N Rev A 2278 10 FLPADFFPSV N Y N N N No A 2279 10 FLPDDFFPSA L2.SD4 N Y N N N Rev A 2280 10 FLPDDFFPSV N Y N N N No A 2281 10 FLPNDFFPSA L2.SN4 N Y N N N Rev A 2282 10 FLPNDFFPSV N Y N N N No A 2263 10 FLPS(X)YFPSV N N N N N A 2284 10 FLPSAFFPSV N Y N N N No A 2285 10 FLPSD(X)FPSV N N N N N A 2266 10 FLPSDAFPSV N Y N N N No A 2287 10 FLPSDFAPSV N Y N N N No A 2288 FLPSDFF-NH2 2289 10 FLPSDFFASV N Y N N N No A 2290 10 FLPSDFFKSV N Y N N N No A 2291 8 FLPSDFFP N N N N N A 2292 FLPSDFFP-NH2 2293 10 FLPSDFFPAV N Y N N N No A 2294 10 FLPSDFFPKV N Y N N N No A 2295 9 FLPSDFFPS N N N N N A 2296 FLPSDFFPS-NH2 2297 10 FLPSDFFPSA L2.VA10 N Y N N N Rev A 2298 10 FLPSDFFPSI L2.V110 N Y N N N Rev A 2299 FLPSDFFPSV(CONH2) 2300 FLPSDFFPSV-NH2 2301 11 FLPSDFFPSVR N N Y N N A 2302 FLPSDFFPSVR-NH2 2303 12 FLPSDFFPSVRD N N N N N A 2304 10 FLPSDFYPSV N Y N N N No A 2305 11 FLPSDLLPSVR N N Y N N A 2306 10 FLPSDYPPSV N Y N N N No A 2307 10 FLPSEFFPSV N Y N N N No A 2308 9 FLPSYPPSA L2.FY5 N Y N N N Rev3 A 2309 9 FLPSYFPSV L2.FY5 N Y N N N 3 A 2310 10 FLPSZFFPSV N Y N N N No A 2311 10 FLPSZFFPSV N Y N N N No A 2312 10 FLPVDFFPSI L2.SV4 N Y N N N Rev A 2313 10 FLPVDFFPSV N Y N N N No A 2314 FLSKQYLNL 2315 9 FLYTRILTI N Y N N N A 2316 8 FMFSPTYK N N Y N N A 2317 10 FMLLLLCLIFL IM2.L10 N Y N Y N 1 A 2318 10 FMPSDFFPSV LM2.V1 N Y N N N 1 A 2319 8 FPAAMPHL N Y N N N A 2320 9 FPAAMPHLL N N N N Y A 2321 10 FPAAMPHLLV N N N N Y A 2322 9 FPALMPLYA N N N N Y A 2223 10 FPARVTGGVF N N N N Y A 2324 10 FPCALRFTSA N N N N Y A 2325 9 FPFCLAFSY N N N N Y A 2326 10 FPFCLAFSYM N N N N Y A 2327 9 FPHCLAFAL N N N N Y A 2328 9 FPHCLAFAY N N N N Y A 2329 9 FPHCLAFSA N N N N Y A 2330 9 FPHCLAFSI N N N N Y A 2331 9 FPHCLAFSL N N N N Y A 2332 10 FPHCLAFSYI N N N N Y A 2333 10 FPHXLAFSYM N N N N Y A 2334 9 FPIPSSWAF N N N N Y A 2335 9 FPSRGRLGL N N N N Y A 2336 9 FPVCAFSSA N N N N Y A 2337 9 FPVCLAFSY N N N N Y A 2338 10 FQPSDYFPSV N Y N N N Rev A 2339 8 FVFSPTYK N N Y N N A 2340 9 FVLGGXRHK N N Y N N A 2341 9 GLQQVFADV L2.AV9 N Y N N N 1 A 2342 9 GLLGWSPQV L2.AV9 N Y N N N 1 A 2343 9 GLWIRTPPV VL2.AV9 N Y N N N 1 A 2344 9 GLXQVFADA N Y N N N A 2345 10 GMDNSVVLSR N N Y N N A 2346 11 GMDNSVVLSRK N N Y N N A 2347 10 GPCALRFTSI N N N N Y A 2348 10 GPFALRFTSA N N N N Y A 2349 10 GPXALRFTSA N N N N Y A 2350 10 GTFNSVVLSR N N Y N N A 2351 11 GTFNSVVLSRK N N Y N N A 2352 10 GVDNSVVLSR N N Y N N A 2353 11 GVDNSVVLSRK N N Y N N A 2354 10 GYRWMXLRRF N N N Y N A 2355 9 HISXLTFGR N N Y N N A 2356 10 HMLWKAGILY Y N Y N N A 2357 11 HMLWKAGILYK N N Y N N A 2358 8 HPAAMPHI N N N N Y A 2359 9 HPAAMPHLI N N N N Y A 2360 10 HPAAMPHLLI N N N N Y A 2361 8 HPFAMPHL N N N N Y A 2362 9 HPFAMPHLL N N N N Y A 2363 10 HPFAMPHLLV N N N N Y A 2364 10 HTLWKAGILK N N Y N N A 2365 10 HTLWKAGILR N N Y N N A 2366 10 HVLWKAGILY N N Y N N A 2367 11 HVLWKAGILYK N N Y N N A 2368 IIKKSEQFV 2369 9 ILGLLGFAV VL2.AV9 N Y N N N 1 A 2370 10 ILLLCLIFLV L2.LV10 N Y N N N 1 A 2371

9 ILLLXLIFL N Y N N N A 2372 10 ILLLXLIFLL N Y N N N A 2373 9 IPFPSSWAF N N N N Y A 2374 9 IPILSSWAF N N N N Y A 2375 9 IPIPMSWAF N N N N Y A 2376 9 IPIPSSWAI N N N N Y A 2377 9 IPITSSWAF N N N N Y A 2376 KIKESFRKL 2379 9 KLFLYSHPI N Y N N N No A 2380 9 KLHLYSHPV L2.IV9 N Y N N N 1 A 2381 9 KVGNFTGLK N N Y N N A 2382 9 KVGNFTGLR N N Y N N A 2383 9 LLAQFTSAV L2.IV9 N Y N N N 1 A 2384 10 LLFYQGMLPV N Y N N N No A 2385 LLGSAANWI 2386 10 LLGXAANWIL N Y N N N A 2387 9 LLLXLIFLL N Y N N N A 2388 10 LLLXLIFLLV N Y N N N A 2389 10 LLLYQGMLPV N Y N N N No A 2390 9 LLPFVQWFV VL2.V9 N Y N N N 1 A 2391 10 LLPIFFXLWV N Y N N N A 2392 LLSFLPSDFFPSV-NH2 2393 9 LLSSNLSWV L2.LV9 N Y N N N 1 A 2394 10 LLVLQAGFFV L2.LV10 N Y N N N 1 A 2395 LLXLIFLLV N Y N N N A 2396 10 LMLLDYQGMV VM2.LV N Y N N N 1 A 2397 10 LMLQAGFFLV VM2.LV N Y N N N 1 A 2398 9 LMPFVQWNFV VM2.V9 N Y N N N 1 A 2399 9 LPFCAFSSA N N N N Y A 2400 8 LPIFFCLI N N N N Y A 2401 9 LPIFFCLWI N N N N Y A 2402 9 LPIHTAELI N N N N Y A 2403 11 LPIHTAELLAI N N N N Y A 2404 LPSDFFPSV-NH2 2405 9 LPVCAFSSI N N N N Y A 2406 9 LPVXAFSSA N N N N Y A 2407 12 LSFLPSDFFPSV N N N N N A 2408 LSFLPSDFFPSV-NH2 2409 10 MMWYWGPSLK N N Y N N A 2410 10 MMWYWGPSLR N N Y N N A 2411 9 MMWYWGPSV M2.LV9 N Y N N N 1 A 2412 8 MPLSYQHI N N N N Y A 2413 9 NLGNLNVSV L2.IV9 N Y N N N 1 A 2414 NLNNLNVSI 2415 9 NMGLKYRQL N Y N Y N No A 2416 11 NPLGFFPDHQI N N N N Y A 2417 9 PLLPIFFCV L2.LV9 N Y N N N 1 A 2418 9 PLLPIFFXL N Y N N N A 2419 8 PSDFFPSV N N N N N A 2420 PSDFFPSV-NH2 2421 10 QLLWFHISXL N Y N N N A 2422 10 QMFTFSPTYK N N Y N N A 2423 10 QVFTFSPTYK N N Y N N A 2424 RIPRTPRSV 2425 9 RLSWPKFAV VL2.V9 N Y N N N 1 A 2426 9 RLTGGVFLV VL2.V9 N Y N N N 1 A 2427 9 RMLTIPQSV IM2.LV9 N Y N N N 1 A 2428 9 RMTGGVFLV VM2.V9 N Y N N N 1 A 2429 9 RMYLHTLWK N N Y N N A 2430 9 RVYLHTLWK N N Y N N A 2431 9 SAIXSVVRR N N Y N N A 2432 11 SFLPSDFFPSV N N N N N A 2433 SFLPSDFFPSV-NH2 2434 9 SLDSWWTSV L2.LV9 N Y N N N 1 A 2435 SLNFLGGTTV(NH2) 2436 9 SMICSVVRR N N Y N N A 2437 10 SMLPETTVVR N N Y N N A 2438 11 SMLPETTVVRR N N Y N N A 2439 10 SMLSPFLPLV IM2.LV1 N Y N N N 1 A 2440 8 SPFLLAQI N N N N Y A 2441 11 STLPETYVVRR N N Y N N A 2442 9 SVICSVVRR N N Y N N A 2443 10 SVLPETTVVR N N Y N N A 2444 11 SVLPETTVVRR N N Y N N A 2445 9 SVNRPIDWK N N Y N N A 2446 9 SVVRRAFPK N N Y N N A 2447 9 SVVRRAFPR N N Y N N A 2448 9 TLWKAGILK N N Y N N A 2449 9 TLWKAGILR N N Y N N A 2450 10 TMPETTVVRR N N Y N N A 2451 9 TMWKAGILY Y N Y N N A 2452 10 TMWKAGILYK N N Y N N A 2453 10 TPARVTGGVI N N N N Y A 2454 10 TPFRVTGGVF N N N N Y A 2455 10 TSAIXSVVRR N N Y N N A 2458 TVELLSFLPSDFFPSV-NH2 2457 10 TVPETTVVRR N N Y N N A 2468 9 TVWKAGILY N N Y N N A 2459 10 TVWKAGILYK N N Y N N A 2460 VELLSFLPSDFFPSV-NH2 2461 VLEYLVSFGV(NH2) 2462 VLGGSRHKL 2463 9 VLLDYQGMV L2.LV9 N Y N N N 1 A 2464 9 VLQAGFFLV L2.LV9 N Y N N N 1 A 2465 10 VMGGVFLVDK N N Y N N A 2466 10 VPFVQWFVGI N N N N Y A 2467 8 VPSALNPI N N N N Y A 2468 9 WFFSQFSR N N Y N N A 2469 10 VVGGVFLVDK N N Y N N A 2470 9 WLLRGTSFV IL2.V9 N Y N N N 1 A 2471 10 YLFTLWKAGI N Y N N N No A 2472 10 YLHTLWKAGV L2.IV10 N Y N N N 1 A 2473 10 YLLTLWKAGI N Y N N N No A 2474 9 YLLTRILTI N Y N N N A 2475 9 YLPSDFFPSV VL2.AV9 N Y N N N 1 A 2476 10 YLPSDFFPSV N Y N N N No A 2477 9 YMDDVVLGV M2.AV9 N Y N N N 1 A 2478 9 VMFDVVLGA N Y N N N No A 2479 10 YMFDVVLGAK N N Y N N A 2480 10 YNMGLKFRQL N N N N N A 2481 8 YPALMPLI N N N N Y A 2482 9 VPALMPLYI N N N N Y A 2483 9 YPFLMPLVA N N N N Y A 2484 12 YSFLPSDFFPSV N N N N N A 2485 236

TABLE-US-00023 TABLE XXII Discreet substitutions improve the B7 supertype binding capacity and degeneracy of peptide ligands. ##STR00001##

TABLE-US-00024 TABLE XXIII Sets of preferred epitopes restricted by class I and class II molecules can be selected for inclusion in an HBV-specific vaccine. Table XXIII lists as a matter of example one such set of epitopes. SEQ ID Peptide Sequence Protein restriction NO: A) Class I restricted epitopes 924.07 FLPSDFFPSV core 18 A2 2521 777.03 FLLTRILTI env 183 A2 2522 927.15 ALMPLYACI pol 642 A2 2523 1013.01 WLSLLVPFV env 335 A2 2524 1090.14 YMDDVVLGA pol 538 A2/A1 2525 1168.02 GLSRYVARL pol 455 A2 2526 927.11 FLLSLGIHL pol 562 A2 2527 1069.10 LLPIFFCLWV env 378 A2 2528 1069.06 LLVPFVQWFV env 338 A2 2529 1147.16 HTLWKAGILYK pol 149 A3/A1 2530 1083.01 STLPETTVVRR core 141 A3 2531 1069.16 NVSIPWTHK pol 47 A3 2532 1069.20 LVVDFSQFSR pol 388 A3 2533 1090.10 QAFTFSPTYK pol 665 A3 2534 1090.11 SAICSVVRR pol 531 A3 2535 1142.05 KVGNFTGLY pol 629 A3/A1 2536 1147.05 FPHCLAFSYM pol 530 B7 2537 988.05 LPSDFPPSV core 19 B7 2538 1145.04 IPIPSSWAF env 313 B7 2539 1147.02 HPAAMPHLL pol 429 B7 2540 26.0570 YPALMPLYACI pol 640 B7 2541 1147.04 TPARVTGGVF pol 354 B7 2542 1.0519 DLLDTASALY core 419 A1 2543 2.0239 LSLDVSAAFY pol 1000 A1 2544 1039.06 WMMWYWGPSLY env 359 A1 2545 20.0269 RWMCLRRFII env 236 A24 2546 20.0136 SWLSLLVPF env 334 A24 2547 20.0137 SWWTSLNFL env 197 A24 2548 13.0129 EYLVSFGVWI core 117 A24 2549 1090.02 AYRPPNAPI core 131 A24 2550 13.0073 WFHISCLTF core 102 A24 2551 20.0271 SWPKFAVPNL pol 392 A24 2552 1069.23 KYTSFPWLL pol 745 A24 2553 2.0181 LYSHPIILGF pol 492 A24 2554 B) Glass II restricted epitopes F107.03 LQSLTNLLSSNLSWL pol 412 DR 2555 supermotif 1298.06 KQAFTESPTYKAFLC pol 664 2556 1280.06 AGFFLLTRILTIPQS env 180 2557 1280.09 GTSFVYVPSALNPAD pol 774 2558 CF-08 VSFGVWIRTPPAYRPPNAPI core 120 2559 27.0281 RHYLHTLWKAGILYK pol 145 2560 1186.15 LVPFVQWFVGLSPTV env 339 2561 1280.15 LHLYSHPIILGFRKI pol 501 2562 F107.04 PFLLAQFTSAICSVV pol 523 2563 1298.04 KQCFRKLPVNRPIDW pol 618 2564 1298.07 AANWILRGTSFVYVP pol 767 2565 857.02 PHHTALRQAILCWGELMTLA core 50 2566 1280.14 LCQVFADATPTGWGL pol 694 DR3 motif 2567 35.0096 ESRLVVDFSQFSRGN pol 385 2568 35.0093 VGPLTVNEKRRLKLI pol 96 2569 1186.27 SSNLSWLSLDVSAAF pol 420 2570 1186.18 NLSWLSLDVSAAFYH pol 442 2571

Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 2579 <210> SEQ ID NO 1 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1 Ala Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 10 <210> SEQ ID NO 2 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2 Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 <210> SEQ ID NO 3 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 3 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 4 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 4 Ala Ser Phe Cys Gly Ser Pro Tyr 1 5 <210> SEQ ID NO 5 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 5 Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp 1 5 10 <210> SEQ ID NO 6 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 6 Ala Ser Lys Leu Cys Leu Gly Trp 1 5 <210> SEQ ID NO 7 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 7 Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp 1 5 10 <210> SEQ ID NO 8 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 8 Ala Ser Pro Leu His Val Ala Trp 1 5 <210> SEQ ID NO 9 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 9 Cys Ile Pro Ile Pro Ser Ser Trp 1 5 <210> SEQ ID NO 10 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 10 Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 10 <210> SEQ ID NO 11 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 11 Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 12 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 12 Cys Leu Arg Arg Phe Ile Ile Phe 1 5 <210> SEQ ID NO 13 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 13 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 1 5 10 <210> SEQ ID NO 14 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 14 Cys Ser Val Val Arg Arg Ala Phe 1 5 <210> SEQ ID NO 15 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 15 Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp 1 5 10 <210> SEQ ID NO 16 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 16 Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 17 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 17 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 18 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 18 Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 19 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 19 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 10 <210> SEQ ID NO 20 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 20 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 21 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 21 Glu Ser Arg Leu Val Val Asp Phe 1 5 <210> SEQ ID NO 22 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 22 Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 10 <210> SEQ ID NO 23 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 23 Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 24 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 24 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 25 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 25 Phe Leu Leu Val Leu Leu Asp Tyr 1 5 <210> SEQ ID NO 26 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 26 Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 <210> SEQ ID NO 27 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 27 Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 10 <210> SEQ ID NO 28 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 28 Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 10 <210> SEQ ID NO 29 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 29 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 10 <210> SEQ ID NO 30 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 30 Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 <210> SEQ ID NO 31 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 31 Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 32 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 32 Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 10 <210> SEQ ID NO 33 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 33 Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 <210> SEQ ID NO 34 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 34 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 10 <210> SEQ ID NO 35 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 35 His Leu Asn Pro Asn Lys Thr Lys Arg Trp 1 5 10 <210> SEQ ID NO 36 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 36 His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 37 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 37 His Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 10 <210> SEQ ID NO 38 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 38 His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 10 <210> SEQ ID NO 39 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 39 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 40 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 40 Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 41 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 41 Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 <210> SEQ ID NO 42 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 42 Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 43 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 43 Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 10 <210> SEQ ID NO 44 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 44 Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 10 <210> SEQ ID NO 45 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 45 Lys Leu Cys Leu Gly Trp Leu Trp 1 5 <210> SEQ ID NO 46 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 46 Lys Leu Ile Met Pro Ala Arg Phe 1 5 <210> SEQ ID NO 47 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 47 Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 48 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 48 Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 <210> SEQ ID NO 49 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 49 Lys Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 50 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 50 Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 <210> SEQ ID NO 51 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 51 Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 52 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 52 Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 53 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 53 Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 <210> SEQ ID NO 54 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 54 Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 55 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 55 Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 56 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 56 Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 <210> SEQ ID NO 57 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 57 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 10 <210> SEQ ID NO 58 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 58 Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 59 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 59 Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 60 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 60 Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 61 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 61 Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 62 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 62 Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 63 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 63 Leu Leu Val Pro Phe Val Gln Trp 1 5 <210> SEQ ID NO 64 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 64 Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 65 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 65 Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 10 <210> SEQ ID NO 66 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 66 Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 67 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 67 Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 <210> SEQ ID NO 68 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 68 Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 69 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 69 Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 70 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 70 Leu Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 10 <210> SEQ ID NO 71 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 71 Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 72 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 72 Leu Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 73 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 73 Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 <210> SEQ ID NO 74 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 74 Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 10 <210> SEQ ID NO 75 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 75 Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 76 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 76 Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 10 <210> SEQ ID NO 77 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 77 Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 78 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 78 Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 10 <210> SEQ ID NO 79 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 79 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 80 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 80 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 81 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 81 Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 10 <210> SEQ ID NO 82 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 82 Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 83 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 83 Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 84 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 84 Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 85 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 85 Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 86 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 86 Met Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 87 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 87 Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 10 <210> SEQ ID NO 88 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 88 Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp 1 5 10 <210> SEQ ID NO 89 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 89 Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 90 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 90 Asn Leu Asn Val Ser Ile Pro Trp 1 5 <210> SEQ ID NO 91 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 91 Asn Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 10 <210> SEQ ID NO 92 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 92 Asn Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 93 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 93 Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 <210> SEQ ID NO 94 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 94 Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 95 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 95 Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 <210> SEQ ID NO 96 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 96 Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 97 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 97 Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 10 <210> SEQ ID NO 98 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 98 Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 99 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 99 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 100 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 100 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 101 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 101 Pro Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 102 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 102 Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 103 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 103 Pro Val Asn Arg Pro Ile Asp Trp 1 5 <210> SEQ ID NO 104 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 104 Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 10 <210> SEQ ID NO 105 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 105 Arg Ile Val Gly Leu Leu Gly Phe 1 5 <210> SEQ ID NO 106 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 106 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 10 <210> SEQ ID NO 107 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 107 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 10 <210> SEQ ID NO 108 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 108 Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 109 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 109 Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 110 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 110 Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 <210> SEQ ID NO 111 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 111 Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 112 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 112 Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 113 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 113 Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 <210> SEQ ID NO 114 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 114 Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 <210> SEQ ID NO 115 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 115 Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 116 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 116 Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 117 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 117 Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 10 <210> SEQ ID NO 118 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 118 Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 119 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 119 Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 120 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 120 Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 121 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 121 Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 122 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 122 Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 123 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 123 Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 <210> SEQ ID NO 124 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 124 Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 125 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 125 Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 126 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 126 Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 127 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 127 Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 128 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 128 Thr Val Gln Ala Ser Lys Leu Cys Leu Gly Trp 1 5 10 <210> SEQ ID NO 129 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 129 Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 130 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 130 Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 131 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 131 Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 10 <210> SEQ ID NO 132 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 132 Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 133 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 133 Trp Ile Leu Arg Gly Thr Ser Phe 1 5 <210> SEQ ID NO 134 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 134 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 10 <210> SEQ ID NO 135 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 135 Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 <210> SEQ ID NO 136 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 136 Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 137 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 137 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 <210> SEQ ID NO 138 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 138 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 139 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 139 Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 140 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 140 Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 10 <210> SEQ ID NO 141 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 141 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 10 <210> SEQ ID NO 142 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 142 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 143 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 143 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 144 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 144 Trp Thr His Lys Val Gly Asn Phe 1 5 <210> SEQ ID NO 145 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 145 Tyr Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 10 <210> SEQ ID NO 146 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 146 Tyr Leu Val Ser Phe Gly Val Trp 1 5 <210> SEQ ID NO 147 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 147 Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 <210> SEQ ID NO 148 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 148 Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 <210> SEQ ID NO 149 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 149 Ala Ala Cys Phe Ala Arg Ser Arg Ser Gly Ala 1 5 10 <210> SEQ ID NO 150 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 150 Ala Ala Met Pro His Leu Leu Val 1 5 <210> SEQ ID NO 151 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 151 Ala Ala Asn Trp Ile Leu Arg Gly Thr 1 5 <210> SEQ ID NO 152 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 152 Ala Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala 1 5 10 <210> SEQ ID NO 153 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 153 Ala Ile Cys Ser Val Val Arg Arg Ala 1 5 <210> SEQ ID NO 154 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 154 Ala Ile Leu Cys Trp Gly Glu Leu 1 5 <210> SEQ ID NO 155 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 155 Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 156 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 156 Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 157 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 157 Ala Met Gln Trp Asn Ser Thr Thr 1 5 <210> SEQ ID NO 158 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 158 Ala Met Ser Thr Thr Asp Leu Glu Ala 1 5 <210> SEQ ID NO 159 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 159 Ala Thr Pro Thr Gly Trp Gly Leu 1 5 <210> SEQ ID NO 160 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 160 Ala Thr Pro Thr Gly Trp Gly Leu Ala 1 5 <210> SEQ ID NO 161 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 161 Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 10 <210> SEQ ID NO 162 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 162 Ala Val Pro Asn Leu Gln Ser Leu 1 5 <210> SEQ ID NO 163 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 163 Ala Val Pro Asn Leu Gln Ser Leu Thr 1 5 <210> SEQ ID NO 164 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 164 Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu 1 5 10 <210> SEQ ID NO 165 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 165 Cys Ala Ala Asn Trp Ile Leu Arg Gly Thr 1 5 10 <210> SEQ ID NO 166 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 166 Cys Ala Phe Ser Ser Ala Gly Pro Cys Ala 1 5 10 <210> SEQ ID NO 167 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 167 Cys Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 10 <210> SEQ ID NO 168 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 168 Cys Ala Leu Arg Phe Thr Ser Ala 1 5 <210> SEQ ID NO 169 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 169 Cys Ile Pro Ile Pro Ser Ser Trp Ala 1 5 <210> SEQ ID NO 170 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 170 Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala 1 5 10 <210> SEQ ID NO 171 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 171 Cys Leu Ala Phe Ser Tyr Met Asp Asp Val 1 5 10 <210> SEQ ID NO 172 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 172 Cys Leu Ala Phe Ser Tyr Met Asp Asp Val Val 1 5 10 <210> SEQ ID NO 173 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 173 Cys Leu Gly Trp Leu Trp Gly Met 1 5 <210> SEQ ID NO 174 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 174 Cys Leu Gly Trp Leu Trp Gly Met Asp Ile 1 5 10 <210> SEQ ID NO 175 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 175 Cys Leu Ile Phe Leu Leu Val Leu 1 5 <210> SEQ ID NO 176 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 176 Cys Leu Ile Phe Leu Leu Val Leu Leu 1 5 <210> SEQ ID NO 177 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 177 Cys Leu Arg Arg Phe Ile Ile Phe Leu 1 5 <210> SEQ ID NO 178 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 178 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile 1 5 10 <210> SEQ ID NO 179 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 179 Cys Leu Thr Phe Gly Arg Glu Thr 1 5 <210> SEQ ID NO 180 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 180 Cys Leu Thr Phe Gly Arg Glu Thr Val 1 5 <210> SEQ ID NO 181 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 181 Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala 1 5 10 <210> SEQ ID NO 182 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 182 Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 <210> SEQ ID NO 183 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 183 Asp Ala Thr Pro Thr Gly Trp Gly Leu Ala 1 5 10 <210> SEQ ID NO 184 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 184 Asp Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 10 <210> SEQ ID NO 185 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 185 Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala 1 5 10 <210> SEQ ID NO 186 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 186 Asp Leu Leu Asp Thr Ala Ser Ala 1 5 <210> SEQ ID NO 187 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 187 Asp Leu Leu Asp Thr Ala Ser Ala Leu 1 5 <210> SEQ ID NO 188 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 188 Asp Leu Asn Leu Gly Asn Leu Asn Val 1 5 <210> SEQ ID NO 189 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 189 Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 10 <210> SEQ ID NO 190 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 190 Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala 1 5 10 <210> SEQ ID NO 191 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 191 Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 <210> SEQ ID NO 192 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 192 Asp Val Leu Cys Leu Arg Pro Val 1 5 <210> SEQ ID NO 193 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 193 Asp Val Leu Cys Leu Arg Pro Val Gly Ala 1 5 10 <210> SEQ ID NO 194 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 194 Asp Val Val Leu Gly Ala Lys Ser Val 1 5 <210> SEQ ID NO 195 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 195 Glu Ala Gly Pro Leu Glu Glu Glu Leu 1 5 <210> SEQ ID NO 196 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 196 Glu Leu Gly Glu Glu Ile Arg Leu 1 5 <210> SEQ ID NO 197 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 197 Glu Leu Leu Ala Ala Cys Phe Ala 1 5 <210> SEQ ID NO 198 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 198 Glu Thr Val Leu Glu Tyr Leu Val 1 5 <210> SEQ ID NO 199 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 199 Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 <210> SEQ ID NO 200 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 200 Phe Ala Arg Ser Arg Ser Gly Ala 1 5 <210> SEQ ID NO 201 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 201 Phe Ala Ser Pro Leu His Val Ala 1 5 <210> SEQ ID NO 202 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 202 Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 <210> SEQ ID NO 203 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 203 Phe Ala Val Pro Asn Leu Gln Ser Leu Thr 1 5 10 <210> SEQ ID NO 204 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 204 Phe Ile Ile Phe Leu Phe Ile Leu 1 5 <210> SEQ ID NO 205 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 205 Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 <210> SEQ ID NO 206 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 206 Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 1 5 10 <210> SEQ ID NO 207 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 207 Phe Ile Leu Leu Leu Cys Leu Ile 1 5 <210> SEQ ID NO 208 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 208 Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 209 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 209 Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 210 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 210 Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 <210> SEQ ID NO 211 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 211 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 10 <210> SEQ ID NO 212 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 212 Phe Leu Gly Pro Leu Leu Val Leu 1 5 <210> SEQ ID NO 213 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 213 Phe Leu Gly Pro Leu Leu Val Leu Gln Ala 1 5 10 <210> SEQ ID NO 214 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 214 Phe Leu Leu Ala Gln Phe Thr Ser Ala 1 5 <210> SEQ ID NO 215 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 215 Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 10 <210> SEQ ID NO 216 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 216 Phe Leu Leu Ser Leu Gly Ile His Leu 1 5 <210> SEQ ID NO 217 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 217 Phe Leu Leu Thr Arg Ile Leu Thr 1 5 <210> SEQ ID NO 218 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 218 Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 219 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 219 Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 220 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 220 Phe Leu Val Asp Lys Asn Pro His Asn Thr 1 5 10 <210> SEQ ID NO 221 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 221 Phe Thr Phe Ser Pro Thr Tyr Lys Ala 1 5 <210> SEQ ID NO 222 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 222 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 10 <210> SEQ ID NO 223 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 223 Phe Thr Gly Leu Tyr Ser Ser Thr 1 5 <210> SEQ ID NO 224 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 224 Phe Thr Gly Leu Tyr Ser Ser Thr Val 1 5 <210> SEQ ID NO 225 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 225 Phe Thr Gln Cys Gly Tyr Pro Ala 1 5 <210> SEQ ID NO 226 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 226 Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 <210> SEQ ID NO 227 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 227 Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met 1 5 10 <210> SEQ ID NO 228 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 228 Phe Thr Ser Ala Ile Cys Ser Val 1 5 <210> SEQ ID NO 229 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 229 Phe Thr Ser Ala Ile Cys Ser Val Val 1 5 <210> SEQ ID NO 230 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 230 Phe Val Gly Leu Ser Pro Thr Val 1 5 <210> SEQ ID NO 231 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 231 Phe Val Gly Leu Ser Pro Thr Val Trp Leu 1 5 10 <210> SEQ ID NO 232 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 232 Phe Val Leu Gly Gly Cys Arg His Lys Leu 1 5 10 <210> SEQ ID NO 233 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 233 Phe Val Leu Gly Gly Cys Arg His Lys Leu Val 1 5 10 <210> SEQ ID NO 234 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 234 Phe Val Gln Trp Phe Val Gly Leu 1 5 <210> SEQ ID NO 235 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 235 Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr 1 5 10 <210> SEQ ID NO 236 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 236 Phe Val Tyr Val Pro Ser Ala Leu 1 5 <210> SEQ ID NO 237 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 237 Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala 1 5 10 <210> SEQ ID NO 238 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 238 Gly Ala His Leu Ser Leu Arg Gly Leu 1 5 <210> SEQ ID NO 239 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 239 Gly Ala His Leu Ser Leu Arg Gly Leu Pro Val 1 5 10 <210> SEQ ID NO 240 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 240 Gly Ala Lys Ser Val Gln His Leu 1 5 <210> SEQ ID NO 241 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 241 Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu 1 5 10 <210> SEQ ID NO 242 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 242 Gly Ile His Leu Asn Pro Asn Lys Thr 1 5 <210> SEQ ID NO 243 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 243 Gly Ile Leu Tyr Lys Arg Glu Thr 1 5 <210> SEQ ID NO 244 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 244 Gly Ile Leu Tyr Lys Arg Glu Thr Thr 1 5 <210> SEQ ID NO 245 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 245 Gly Leu Cys Gln Val Phe Ala Asp Ala 1 5 <210> SEQ ID NO 246 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 246 Gly Leu Cys Gln Val Phe Ala Asp Ala Thr 1 5 10 <210> SEQ ID NO 247 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 247 Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr 1 5 10 <210> SEQ ID NO 248 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 248 Gly Leu Leu Gly Trp Ser Pro Gln Ala 1 5 <210> SEQ ID NO 249 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 249 Gly Leu Pro Val Cys Ala Phe Ser Ser Ala 1 5 10 <210> SEQ ID NO 250 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 250 Gly Leu Ser Pro Phe Leu Leu Ala 1 5 <210> SEQ ID NO 251 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 251 Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe Thr 1 5 10 <210> SEQ ID NO 252 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 252 Gly Leu Ser Pro Thr Val Trp Leu 1 5 <210> SEQ ID NO 253 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 253 Gly Leu Ser Pro Thr Val Trp Leu Ser Val 1 5 10 <210> SEQ ID NO 254 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 254 Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 10 <210> SEQ ID NO 255 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 255 Gly Met Leu Pro Val Cys Pro Leu 1 5 <210> SEQ ID NO 256 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 256 Gly Thr Asp Asn Ser Val Val Leu 1 5 <210> SEQ ID NO 257 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 257 Gly Thr Asn Leu Ser Val Pro Asn Pro Leu 1 5 10 <210> SEQ ID NO 258 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 258 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala 1 5 10 <210> SEQ ID NO 259 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 259 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 10 <210> SEQ ID NO 260 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 260 Gly Val Gly Leu Ser Pro Phe Leu 1 5 <210> SEQ ID NO 261 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 261 Gly Val Gly Leu Ser Pro Phe Leu Leu 1 5 <210> SEQ ID NO 262 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 262 Gly Val Gly Leu Ser Pro Phe Leu Leu Ala 1 5 10 <210> SEQ ID NO 263 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 263 Gly Val Trp Ile Arg Thr Pro Pro Ala 1 5 <210> SEQ ID NO 264 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 264 His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr 1 5 10 <210> SEQ ID NO 265 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 265 His Leu Leu Val Gly Ser Ser Gly Leu 1 5 <210> SEQ ID NO 266 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 266 His Leu Ser Leu Arg Gly Leu Pro Val 1 5 <210> SEQ ID NO 267 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 267 His Leu Ser Leu Arg Gly Leu Pro Val Cys Ala 1 5 10 <210> SEQ ID NO 268 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 268 His Leu Tyr Ser His Pro Ile Ile 1 5 <210> SEQ ID NO 269 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 269 His Leu Tyr Ser His Pro Ile Ile Leu 1 5 <210> SEQ ID NO 270 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 270 His Thr Ala Glu Leu Leu Ala Ala 1 5 <210> SEQ ID NO 271 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 271 His Thr Ala Glu Leu Leu Ala Ala Cys Phe Ala 1 5 10 <210> SEQ ID NO 272 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 272 His Thr Ala Leu Arg Gln Ala Ile 1 5 <210> SEQ ID NO 273 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 273 His Thr Ala Leu Arg Gln Ala Ile Leu 1 5 <210> SEQ ID NO 274 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 274 His Thr Leu Trp Lys Ala Gly Ile 1 5 <210> SEQ ID NO 275 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 275 His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 <210> SEQ ID NO 276 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 276 Ile Ile Phe Leu Phe Ile Leu Leu 1 5 <210> SEQ ID NO 277 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 277 Ile Ile Phe Leu Phe Ile Leu Leu Leu 1 5 <210> SEQ ID NO 278 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 278 Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 10 <210> SEQ ID NO 279 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 279 Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 280 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 280 Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 281 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 281 Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 282 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 282 Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 <210> SEQ ID NO 283 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 283 Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 <210> SEQ ID NO 284 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 284 Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 285 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 285 Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 10 <210> SEQ ID NO 286 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 286 Ile Leu Arg Gly Thr Ser Phe Val 1 5 <210> SEQ ID NO 287 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 287 Ile Leu Arg Gly Thr Ser Phe Val Tyr Val 1 5 10 <210> SEQ ID NO 288 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 288 Ile Leu Ser Thr Leu Pro Glu Thr 1 5 <210> SEQ ID NO 289 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 289 Ile Leu Ser Thr Leu Pro Glu Thr Thr 1 5 <210> SEQ ID NO 290 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 290 Ile Leu Ser Thr Leu Pro Glu Thr Thr Val 1 5 10 <210> SEQ ID NO 291 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 291 Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val 1 5 10 <210> SEQ ID NO 292 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 292 Ile Leu Thr Ile Pro Gln Ser Leu 1 5 <210> SEQ ID NO 293 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 293 Ile Leu Tyr Lys Arg Glu Thr Thr 1 5 <210> SEQ ID NO 294 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 294 Ile Val Gly Leu Leu Gly Phe Ala 1 5 <210> SEQ ID NO 295 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 295 Ile Val Gly Leu Leu Gly Phe Ala Ala 1 5 <210> SEQ ID NO 296 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 296 Lys Ala Gly Ile Leu Tyr Lys Arg Glu Thr 1 5 10 <210> SEQ ID NO 297 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 297 Lys Ala Gly Ile Leu Tyr Lys Arg Glu Thr Thr 1 5 10 <210> SEQ ID NO 298 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 298 Lys Ile Pro Met Gly Val Gly Leu 1 5 <210> SEQ ID NO 299 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 299 Lys Leu Cys Leu Gly Trp Leu Trp Gly Met 1 5 10 <210> SEQ ID NO 300 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 300 Lys Leu His Leu Tyr Ser His Pro Ile 1 5 <210> SEQ ID NO 301 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 301 Lys Leu His Leu Tyr Ser His Pro Ile Ile 1 5 10 <210> SEQ ID NO 302 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 302 Lys Leu His Leu Tyr Ser His Pro Ile Ile Leu 1 5 10 <210> SEQ ID NO 303 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 303 Lys Leu Pro Val Asn Arg Pro Ile 1 5 <210> SEQ ID NO 304 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 304 Lys Thr Lys Arg Trp Gly Tyr Ser Leu 1 5 <210> SEQ ID NO 305 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 305 Lys Val Cys Gln Arg Ile Val Gly Leu 1 5 <210> SEQ ID NO 306 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 306 Lys Val Cys Gln Arg Ile Val Gly Leu Leu 1 5 10 <210> SEQ ID NO 307 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 307 Lys Val Gly Asn Phe Thr Gly Leu 1 5 <210> SEQ ID NO 308 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 308 Lys Val Leu His Lys Arg Thr Leu 1 5 <210> SEQ ID NO 309 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 309 Lys Val Leu His Lys Arg Thr Leu Gly Leu 1 5 10 <210> SEQ ID NO 310 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 310 Leu Ala Phe Ser Tyr Met Asp Asp Val 1 5 <210> SEQ ID NO 311 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 311 Leu Ala Phe Ser Tyr Met Asp Asp Val Val 1 5 10 <210> SEQ ID NO 312 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 312 Leu Ala Phe Ser Tyr Met Asp Asp Val Val Leu 1 5 10 <210> SEQ ID NO 313 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 313 Leu Ala Gln Phe Thr Ser Ala Ile 1 5 <210> SEQ ID NO 314 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 314 Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val 1 5 10 <210> SEQ ID NO 315 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 315 Leu Ile Phe Leu Leu Val Leu Leu 1 5 <210> SEQ ID NO 316 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 316 Leu Leu Ala Gln Phe Thr Ser Ala 1 5 <210> SEQ ID NO 317 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 317 Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 <210> SEQ ID NO 318 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 318 Leu Leu Cys Leu Ile Phe Leu Leu 1 5 <210> SEQ ID NO 319 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 319 Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 <210> SEQ ID NO 320 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 320 Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 1 5 10 <210> SEQ ID NO 321 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 321 Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu 1 5 10 <210> SEQ ID NO 322 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 322 Leu Leu Asp Thr Ala Ser Ala Leu 1 5 <210> SEQ ID NO 323 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 323 Leu Leu Asp Tyr Gln Gly Met Leu 1 5 <210> SEQ ID NO 324 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 324 Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 325 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 325 Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 <210> SEQ ID NO 326 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 326 Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu 1 5 10 <210> SEQ ID NO 327 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 327 Leu Leu Gly Phe Ala Ala Pro Phe Thr 1 5 <210> SEQ ID NO 328 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 328 Leu Leu Gly Trp Ser Pro Gln Ala 1 5 <210> SEQ ID NO 329 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 329 Leu Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile 1 5 10 <210> SEQ ID NO 330 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 330 Leu Leu Leu Cys Leu Ile Phe Leu 1 5 <210> SEQ ID NO 331 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 331 Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 <210> SEQ ID NO 332 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 332 Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 10 <210> SEQ ID NO 333 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 333 Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 1 5 10 <210> SEQ ID NO 334 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 334 Leu Leu Pro Ile Phe Phe Cys Leu 1 5 <210> SEQ ID NO 335 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 335 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 10 <210> SEQ ID NO 336 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 336 Leu Leu Ser Leu Gly Ile His Leu 1 5 <210> SEQ ID NO 337 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 337 Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 <210> SEQ ID NO 338 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 338 Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu 1 5 10 <210> SEQ ID NO 339 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 339 Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 340 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 340 Leu Leu Val Gly Ser Ser Gly Leu 1 5 <210> SEQ ID NO 341 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 341 Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 342 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 342 Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 10 <210> SEQ ID NO 343 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 343 Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 10 <210> SEQ ID NO 344 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 344 Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 10 <210> SEQ ID NO 345 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 345 Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 <210> SEQ ID NO 346 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 346 Leu Leu Trp Phe His Ile Ser Cys Leu 1 5 <210> SEQ ID NO 347 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 347 Leu Leu Trp Phe His Ile Ser Cys Leu Thr 1 5 10 <210> SEQ ID NO 348 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 348 Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 349 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 349 Leu Thr Phe Gly Arg Glu Thr Val 1 5 <210> SEQ ID NO 350 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 350 Leu Thr Phe Gly Arg Glu Thr Val Leu 1 5 <210> SEQ ID NO 351 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 351 Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 <210> SEQ ID NO 352 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 352 Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 <210> SEQ ID NO 353 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 353 Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 354 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 354 Leu Val Asp Lys Asn Pro His Asn Thr 1 5 <210> SEQ ID NO 355 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 355 Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 356 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 356 Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 10 <210> SEQ ID NO 357 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 357 Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 <210> SEQ ID NO 358 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 358 Leu Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 10 <210> SEQ ID NO 359 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 359 Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr 1 5 10 <210> SEQ ID NO 360 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 360 Leu Val Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 361 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 361 Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 10 <210> SEQ ID NO 362 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 362 Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 363 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 363 Leu Val Ser Phe Gly Val Trp Ile Arg Thr 1 5 10 <210> SEQ ID NO 364 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 364 Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 <210> SEQ ID NO 365 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 365 Asn Ala Pro Ile Leu Ser Thr Leu 1 5 <210> SEQ ID NO 366 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 366 Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr 1 5 10 <210> SEQ ID NO 367 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 367 Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 <210> SEQ ID NO 368 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 368 Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 10 <210> SEQ ID NO 369 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 369 Asn Leu Asn Val Ser Ile Pro Trp Thr 1 5 <210> SEQ ID NO 370 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 370 Asn Leu Gln Ser Leu Thr Asn Leu 1 5 <210> SEQ ID NO 371 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 371 Asn Leu Gln Ser Leu Thr Asn Leu Leu 1 5 <210> SEQ ID NO 372 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 372 Asn Leu Ser Val Pro Asn Pro Leu 1 5 <210> SEQ ID NO 373 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 373 Asn Leu Ser Trp Leu Ser Leu Asp Val 1 5 <210> SEQ ID NO 374 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 374 Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala 1 5 10 <210> SEQ ID NO 375 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 375 Asn Val Ser Ile Pro Trp Thr His Lys Val 1 5 10 <210> SEQ ID NO 376 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 376 Pro Ala Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 377 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 377 Pro Ala Ala Met Pro His Leu Leu Val 1 5 <210> SEQ ID NO 378 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 378 Pro Ala Asp Asp Pro Ser Arg Gly Arg Leu 1 5 10 <210> SEQ ID NO 379 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 379 Pro Ala Gly Gly Ser Ser Ser Gly Thr 1 5 <210> SEQ ID NO 380 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 380 Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 1 5 10 <210> SEQ ID NO 381 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 381 Pro Ala Leu Met Pro Leu Tyr Ala 1 5 <210> SEQ ID NO 382 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 382 Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 10 <210> SEQ ID NO 383 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 383 Pro Ala Pro Cys Asn Phe Phe Thr 1 5 <210> SEQ ID NO 384 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 384 Pro Ala Pro Cys Asn Phe Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 385 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 385 Pro Ala Arg Asp Val Leu Cys Leu 1 5 <210> SEQ ID NO 386 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 386 Pro Ala Arg Asp Val Leu Cys Leu Arg Pro Val 1 5 10 <210> SEQ ID NO 387 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 387 Pro Ala Arg Val Thr Gly Gly Val 1 5 <210> SEQ ID NO 388 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 388 Pro Ala Arg Val Thr Gly Gly Val Phe Leu 1 5 10 <210> SEQ ID NO 389 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 389 Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val 1 5 10 <210> SEQ ID NO 390 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 390 Pro Ala Tyr Arg Pro Pro Asn Ala 1 5 <210> SEQ ID NO 391 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 391 Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 10 <210> SEQ ID NO 392 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 392 Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 1 5 10 <210> SEQ ID NO 393 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 393 Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 10 <210> SEQ ID NO 394 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 394 Pro Ile Asp Trp Lys Val Cys Gln Arg Ile Val 1 5 10 <210> SEQ ID NO 395 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 395 Pro Ile Phe Phe Cys Leu Trp Val 1 5 <210> SEQ ID NO 396 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 396 Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 10 <210> SEQ ID NO 397 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 397 Pro Ile His Thr Ala Glu Leu Leu 1 5 <210> SEQ ID NO 398 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 398 Pro Ile His Thr Ala Glu Leu Leu Ala 1 5 <210> SEQ ID NO 399 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 399 Pro Ile His Thr Ala Glu Leu Leu Ala Ala 1 5 10 <210> SEQ ID NO 400 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 400 Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 401 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 401 Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 402 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 402 Pro Ile Leu Ser Thr Leu Pro Glu Thr 1 5 <210> SEQ ID NO 403 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 403 Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr 1 5 10 <210> SEQ ID NO 404 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 404 Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val 1 5 10 <210> SEQ ID NO 405 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 405 Pro Ile Pro Ser Ser Trp Ala Phe Ala 1 5 <210> SEQ ID NO 406 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 406 Pro Leu Glu Glu Glu Leu Pro Arg Leu 1 5 <210> SEQ ID NO 407 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 407 Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala 1 5 10 <210> SEQ ID NO 408 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 408 Pro Leu Gly Phe Phe Pro Asp His Gln Leu 1 5 10 <210> SEQ ID NO 409 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 409 Pro Leu His Pro Ala Ala Met Pro His Leu 1 5 10 <210> SEQ ID NO 410 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 410 Pro Leu His Pro Ala Ala Met Pro His Leu Leu 1 5 10 <210> SEQ ID NO 411 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 411 Pro Leu Leu Pro Ile Phe Phe Cys Leu 1 5 <210> SEQ ID NO 412 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 412 Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 10 <210> SEQ ID NO 413 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 413 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 10 <210> SEQ ID NO 414 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 414 Pro Leu Pro Ile His Thr Ala Glu Leu 1 5 <210> SEQ ID NO 415 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 415 Pro Leu Pro Ile His Thr Ala Glu Leu Leu 1 5 10 <210> SEQ ID NO 416 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 416 Pro Leu Pro Ile His Thr Ala Glu Leu Leu Ala 1 5 10 <210> SEQ ID NO 417 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 417 Pro Leu Ser Tyr Gln His Phe Arg Lys Leu 1 5 10 <210> SEQ ID NO 418 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 418 Pro Leu Ser Tyr Gln His Phe Arg Lys Leu Leu 1 5 10 <210> SEQ ID NO 419 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 419 Pro Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 10 <210> SEQ ID NO 420 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 420 Pro Met Gly Val Gly Leu Ser Pro Phe Leu 1 5 10 <210> SEQ ID NO 421 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 421 Pro Met Gly Val Gly Leu Ser Pro Phe Leu Leu 1 5 10 <210> SEQ ID NO 422 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 422 Pro Thr Gly Trp Gly Leu Ala Ile 1 5 <210> SEQ ID NO 423 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 423 Pro Thr Ser Asn His Ser Pro Thr 1 5 <210> SEQ ID NO 424 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 424 Pro Thr Thr Gly Arg Thr Ser Leu 1 5 <210> SEQ ID NO 425 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 425 Pro Thr Thr Gly Arg Thr Ser Leu Tyr Ala 1 5 10 <210> SEQ ID NO 426 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 426 Pro Thr Val Gln Ala Ser Lys Leu 1 5 <210> SEQ ID NO 427 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 427 Pro Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 10 <210> SEQ ID NO 428 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 428 Pro Thr Val Trp Leu Ser Val Ile 1 5 <210> SEQ ID NO 429 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 429 Pro Thr Val Trp Leu Ser Val Ile Trp Met 1 5 10 <210> SEQ ID NO 430 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 430 Pro Val Cys Ala Phe Ser Ser Ala 1 5 <210> SEQ ID NO 431 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 431 Pro Val Asn Arg Pro Ile Asp Trp Lys Val 1 5 10 <210> SEQ ID NO 432 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 432 Gln Ala Phe Thr Phe Ser Pro Thr 1 5 <210> SEQ ID NO 433 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 433 Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala 1 5 10 <210> SEQ ID NO 434 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 434 Gln Ala Gly Phe Phe Leu Leu Thr 1 5 <210> SEQ ID NO 435 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 435 Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile 1 5 10 <210> SEQ ID NO 436 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 436 Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu 1 5 10 <210> SEQ ID NO 437 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 437 Gln Ala Ile Leu Cys Trp Gly Glu Leu 1 5 <210> SEQ ID NO 438 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 438 Gln Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 10 <210> SEQ ID NO 439 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 439 Gln Ala Met Gln Trp Asn Ser Thr 1 5 <210> SEQ ID NO 440 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 440 Gln Ala Met Gln Trp Asn Ser Thr Thr 1 5 <210> SEQ ID NO 441 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 441 Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu 1 5 10 <210> SEQ ID NO 442 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 442 Gln Leu Asp Pro Ala Arg Asp Val 1 5 <210> SEQ ID NO 443 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 443 Gln Leu Asp Pro Ala Arg Asp Val Leu 1 5 <210> SEQ ID NO 444 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 444 Gln Leu Asp Pro Ala Arg Asp Val Leu Cys Leu 1 5 10 <210> SEQ ID NO 445 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 445 Gln Leu Leu Trp Phe His Ile Ser Cys Leu 1 5 10 <210> SEQ ID NO 446 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 446 Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr 1 5 10 <210> SEQ ID NO 447 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 447 Gln Val Phe Ala Asp Ala Thr Pro Thr 1 5 <210> SEQ ID NO 448 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 448 Arg Ala Phe Pro His Cys Leu Ala 1 5 <210> SEQ ID NO 449 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 449 Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 <210> SEQ ID NO 450 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 450 Arg Ile Val Gly Leu Leu Gly Phe Ala 1 5 <210> SEQ ID NO 451 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 451 Arg Ile Val Gly Leu Leu Gly Phe Ala Ala 1 5 10 <210> SEQ ID NO 452 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 452 Arg Leu Lys Leu Ile Met Pro Ala 1 5 <210> SEQ ID NO 453 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 453 Arg Thr Pro Ala Arg Val Thr Gly Gly Val 1 5 10 <210> SEQ ID NO 454 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 454 Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala 1 5 10 <210> SEQ ID NO 455 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 455 Arg Val Ala Glu Asp Leu Asn Leu 1 5 <210> SEQ ID NO 456 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 456 Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu 1 5 10 <210> SEQ ID NO 457 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 457 Arg Val His Phe Ala Ser Pro Leu 1 5 <210> SEQ ID NO 458 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 458 Arg Val His Phe Ala Ser Pro Leu His Val 1 5 10 <210> SEQ ID NO 459 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 459 Arg Val His Phe Ala Ser Pro Leu His Val Ala 1 5 10 <210> SEQ ID NO 460 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 460 Arg Val Thr Gly Gly Val Phe Leu 1 5 <210> SEQ ID NO 461 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 461 Arg Val Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 462 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 462 Ser Ala Gly Pro Cys Ala Leu Arg Phe Thr 1 5 10 <210> SEQ ID NO 463 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 463 Ser Ala Ile Cys Ser Val Val Arg Arg Ala 1 5 10 <210> SEQ ID NO 464 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 464 Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 <210> SEQ ID NO 465 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 465 Ser Ile Pro Trp Thr His Lys Val 1 5 <210> SEQ ID NO 466 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 466 Ser Leu Asp Ser Trp Trp Thr Ser Leu 1 5 <210> SEQ ID NO 467 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 467 Ser Leu Gly Ile His Leu Asn Pro Asn Lys Thr 1 5 10 <210> SEQ ID NO 468 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 468 Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 <210> SEQ ID NO 469 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 469 Ser Leu Asn Phe Met Gly Tyr Val 1 5 <210> SEQ ID NO 470 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 470 Ser Leu Asn Phe Met Gly Tyr Val Ile 1 5 <210> SEQ ID NO 471 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 471 Ser Leu Arg Gly Leu Pro Val Cys Ala 1 5 <210> SEQ ID NO 472 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 472 Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 10 <210> SEQ ID NO 473 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 473 Ser Thr Gly Pro Cys Lys Thr Cys Thr 1 5 <210> SEQ ID NO 474 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 474 Ser Thr Leu Pro Glu Thr Thr Val 1 5 <210> SEQ ID NO 475 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 475 Ser Thr Leu Pro Glu Thr Thr Val Val 1 5 <210> SEQ ID NO 476 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 476 Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr 1 5 10 <210> SEQ ID NO 477 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 477 Ser Val Gln His Leu Glu Ser Leu 1 5 <210> SEQ ID NO 478 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 478 Ser Val Arg Phe Ser Trp Leu Ser Leu 1 5 <210> SEQ ID NO 479 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 479 Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 1 5 10 <210> SEQ ID NO 480 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 480 Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val 1 5 10 <210> SEQ ID NO 481 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 481 Ser Val Val Leu Ser Arg Lys Tyr Thr 1 5 <210> SEQ ID NO 482 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 482 Ser Val Val Arg Arg Ala Phe Pro His Cys Leu 1 5 10 <210> SEQ ID NO 483 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 483 Thr Ala Glu Leu Leu Ala Ala Cys Phe Ala 1 5 10 <210> SEQ ID NO 484 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 484 Thr Ala Leu Arg Gln Ala Ile Leu 1 5 <210> SEQ ID NO 485 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 485 Thr Ala Ser Ala Leu Tyr Arg Glu Ala 1 5 <210> SEQ ID NO 486 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 486 Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 <210> SEQ ID NO 487 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 487 Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr 1 5 10 <210> SEQ ID NO 488 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 488 Thr Leu Pro Glu Thr Thr Val Val 1 5 <210> SEQ ID NO 489 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 489 Thr Leu Trp Lys Ala Gly Ile Leu 1 5 <210> SEQ ID NO 490 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 490 Thr Thr Gly Arg Thr Ser Leu Tyr Ala 1 5 <210> SEQ ID NO 491 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 491 Thr Thr Ser Thr Gly Pro Cys Lys Thr 1 5 <210> SEQ ID NO 492 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 492 Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr 1 5 10 <210> SEQ ID NO 493 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 493 Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 494 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 494 Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 <210> SEQ ID NO 495 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 495 Thr Val Trp Leu Ser Val Ile Trp Met 1 5 <210> SEQ ID NO 496 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 496 Val Ala Glu Asp Leu Asn Leu Gly Asn Leu 1 5 10 <210> SEQ ID NO 497 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 497 Val Leu Cys Leu Arg Pro Val Gly Ala 1 5 <210> SEQ ID NO 498 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 498 Val Leu Gly Ala Lys Ser Val Gln His Leu 1 5 10 <210> SEQ ID NO 499 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 499 Val Leu Gly Gly Cys Arg His Lys Leu 1 5 <210> SEQ ID NO 500 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 500 Val Leu Gly Gly Cys Arg His Lys Leu Val 1 5 10 <210> SEQ ID NO 501 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 501 Val Leu His Lys Arg Thr Leu Gly Leu 1 5 <210> SEQ ID NO 502 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 502 Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 503 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 503 Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 <210> SEQ ID NO 504 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 504 Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 505 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 505 Val Leu Gln Ala Gly Phe Phe Leu 1 5 <210> SEQ ID NO 506 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 506 Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 <210> SEQ ID NO 507 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 507 Val Leu Gln Ala Gly Phe Phe Leu Leu Thr 1 5 10 <210> SEQ ID NO 508 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 508 Val Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 509 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 509 Val Val Leu Gly Ala Lys Ser Val 1 5 <210> SEQ ID NO 510 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 510 Val Val Leu Gly Ala Lys Ser Val Gln His Leu 1 5 10 <210> SEQ ID NO 511 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 511 Val Val Leu Ser Arg Lys Tyr Thr 1 5 <210> SEQ ID NO 512 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 512 Val Val Arg Arg Ala Phe Pro His Cys Leu 1 5 10 <210> SEQ ID NO 513 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 513 Val Val Arg Arg Ala Phe Pro His Cys Leu Ala 1 5 10 <210> SEQ ID NO 514 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 514 Trp Ile Leu Arg Gly Thr Ser Phe Val 1 5 <210> SEQ ID NO 515 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 515 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val 1 5 10 <210> SEQ ID NO 516 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 516 Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 10 <210> SEQ ID NO 517 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 517 Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu 1 5 10 <210> SEQ ID NO 518 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 518 Trp Leu Ser Leu Asp Val Ser Ala 1 5 <210> SEQ ID NO 519 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 519 Trp Leu Ser Leu Asp Val Ser Ala Ala 1 5 <210> SEQ ID NO 520 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 520 Trp Leu Ser Leu Leu Val Pro Phe Val 1 5 <210> SEQ ID NO 521 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 521 Trp Met Cys Leu Arg Arg Phe Ile 1 5 <210> SEQ ID NO 522 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 522 Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 <210> SEQ ID NO 523 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 523 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu 1 5 10 <210> SEQ ID NO 524 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 524 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 10 <210> SEQ ID NO 525 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 525 Trp Thr His Lys Val Gly Asn Phe Thr 1 5 <210> SEQ ID NO 526 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 526 Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu 1 5 10 <210> SEQ ID NO 527 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 527 Tyr Leu His Thr Leu Trp Lys Ala 1 5 <210> SEQ ID NO 528 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 528 Tyr Leu His Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 529 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 529 Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 10 <210> SEQ ID NO 530 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 530 Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 <210> SEQ ID NO 531 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 531 Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 532 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 532 Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 1 5 10 <210> SEQ ID NO 533 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 533 Tyr Met Asp Asp Val Val Leu Gly Ala 1 5 <210> SEQ ID NO 534 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 534 Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 535 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 535 Tyr Thr Ser Phe Pro Trp Leu Leu Gly Cys Ala 1 5 10 <210> SEQ ID NO 536 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 536 Tyr Val Pro Ser Ala Leu Asn Pro Ala 1 5 <210> SEQ ID NO 537 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 537 Ala Ala Cys Phe Ala Arg Ser Arg 1 5 <210> SEQ ID NO 538 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 538 Ala Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 539 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 539 Ala Leu Asn Pro Ala Asp Asp Pro Ser Arg 1 5 10 <210> SEQ ID NO 540 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 540 Ala Leu Arg Phe Thr Ser Ala Arg 1 5 <210> SEQ ID NO 541 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 541 Ala Ser Pro Leu His Val Ala Trp Arg 1 5 <210> SEQ ID NO 542 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 542 Ala Ser Thr Asn Arg Gln Ser Gly Arg 1 5 <210> SEQ ID NO 543 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 543 Cys Ala Ala Asn Trp Ile Leu Arg 1 5 <210> SEQ ID NO 544 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 544 Cys Ala Leu Arg Phe Thr Ser Ala Arg 1 5 <210> SEQ ID NO 545 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 545 Cys Leu Arg Pro Val Gly Ala Glu Ser Arg 1 5 10 <210> SEQ ID NO 546 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 546 Cys Ser Pro His His Thr Ala Leu Arg 1 5 <210> SEQ ID NO 547 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 547 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 10 <210> SEQ ID NO 548 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 548 Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 <210> SEQ ID NO 549 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 549 Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg 1 5 10 <210> SEQ ID NO 550 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 550 Glu Leu Leu Ala Ala Cys Phe Ala Arg 1 5 <210> SEQ ID NO 551 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 551 Glu Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 10 <210> SEQ ID NO 552 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 552 Glu Thr Thr Val Val Arg Arg Arg 1 5 <210> SEQ ID NO 553 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 553 Glu Thr Thr Val Val Arg Arg Arg Gly Arg 1 5 10 <210> SEQ ID NO 554 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 554 Phe Ala Ser Pro Leu His Val Ala Trp Arg 1 5 10 <210> SEQ ID NO 555 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 555 Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg 1 5 10 <210> SEQ ID NO 556 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 556 Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 557 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 557 Phe Thr Ser Ala Ile Cys Ser Val Val Arg 1 5 10 <210> SEQ ID NO 558 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 558 Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 10 <210> SEQ ID NO 559 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 559 Phe Val Leu Gly Gly Cys Arg His Lys 1 5 <210> SEQ ID NO 560 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 560 Gly Ile His Leu Asn Pro Asn Lys 1 5 <210> SEQ ID NO 561 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 561 Gly Ile His Leu Asn Pro Asn Lys Thr Lys 1 5 10 <210> SEQ ID NO 562 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 562 Gly Ile His Leu Asn Pro Asn Lys Thr Lys Arg 1 5 10 <210> SEQ ID NO 563 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 563 Gly Met Asp Ile Asp Pro Tyr Lys 1 5 <210> SEQ ID NO 564 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 564 Gly Thr Asp Asn Ser Val Val Leu Ser Arg 1 5 10 <210> SEQ ID NO 565 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 565 Gly Thr Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 <210> SEQ ID NO 566 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 566 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg 1 5 10 <210> SEQ ID NO 567 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 567 His Ile Ser Cys Leu Thr Phe Gly Arg 1 5 <210> SEQ ID NO 568 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 568 His Leu Asn Pro Asn Lys Thr Lys 1 5 <210> SEQ ID NO 569 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 569 His Leu Asn Pro Asn Lys Thr Lys Arg 1 5 <210> SEQ ID NO 570 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 570 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 571 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 571 Ile Ser Cys Leu Thr Phe Gly Arg 1 5 <210> SEQ ID NO 572 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 572 Lys Ala Gly Ile Leu Tyr Lys Arg 1 5 <210> SEQ ID NO 573 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 573 Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys 1 5 10 <210> SEQ ID NO 574 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 574 Lys Val Phe Val Leu Gly Gly Cys Arg 1 5 <210> SEQ ID NO 575 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 575 Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 <210> SEQ ID NO 576 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 576 Leu Leu Ala Ala Cys Phe Ala Arg 1 5 <210> SEQ ID NO 577 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 577 Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 10 <210> SEQ ID NO 578 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 578 Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 10 <210> SEQ ID NO 579 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 579 Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg 1 5 10 <210> SEQ ID NO 580 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 580 Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 10 <210> SEQ ID NO 581 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 581 Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 582 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 582 Leu Ser Tyr Gln His Phe Arg Lys 1 5 <210> SEQ ID NO 583 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 583 Leu Thr Val Asn Glu Lys Arg Arg 1 5 <210> SEQ ID NO 584 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 584 Leu Val Ser Phe Gly Val Trp Ile Arg 1 5 <210> SEQ ID NO 585 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 585 Leu Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 10 <210> SEQ ID NO 586 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 586 Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 10 <210> SEQ ID NO 587 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 587 Asn Leu Glu Asp Pro Ala Ser Arg 1 5 <210> SEQ ID NO 588 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 588 Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys 1 5 10 <210> SEQ ID NO 589 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 589 Asn Ser Val Val Leu Ser Arg Lys 1 5 <210> SEQ ID NO 590 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 590 Asn Val Ser Ile Pro Trp Thr His Lys 1 5 <210> SEQ ID NO 591 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 591 Pro Ala Asp Asp Pro Ser Arg Gly Arg 1 5 <210> SEQ ID NO 592 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 592 Pro Ala Arg Asp Val Leu Cys Leu Arg 1 5 <210> SEQ ID NO 593 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 593 Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 1 5 10 <210> SEQ ID NO 594 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 594 Pro Ile Asp Trp Lys Val Cys Gln Arg 1 5 <210> SEQ ID NO 595 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 595 Pro Ile Ile Leu Gly Phe Arg Lys 1 5 <210> SEQ ID NO 596 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 596 Pro Leu Glu Glu Glu Leu Pro Arg 1 5 <210> SEQ ID NO 597 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 597 Pro Leu Ser Tyr Gln His Phe Arg 1 5 <210> SEQ ID NO 598 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 598 Pro Leu Ser Tyr Gln His Phe Arg Lys 1 5 <210> SEQ ID NO 599 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 599 Pro Leu Thr Val Asn Glu Lys Arg 1 5 <210> SEQ ID NO 600 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 600 Pro Leu Thr Val Asn Glu Lys Arg Arg 1 5 <210> SEQ ID NO 601 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 601 Pro Val Gly Ala Glu Ser Arg Gly Arg 1 5 <210> SEQ ID NO 602 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 602 Pro Val Asn Arg Pro Ile Asp Trp Lys 1 5 <210> SEQ ID NO 603 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 603 Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 10 <210> SEQ ID NO 604 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 604 Gln Ala Gly Phe Phe Leu Leu Thr Arg 1 5 <210> SEQ ID NO 605 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 605 Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg 1 5 10 <210> SEQ ID NO 606 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 606 Gln Ser Ser Gly Ile Leu Ser Arg 1 5 <210> SEQ ID NO 607 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 607 Arg Leu Lys Leu Ile Met Pro Ala Arg 1 5 <210> SEQ ID NO 608 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 608 Arg Leu Lys Val Phe Val Leu Gly Gly Cys Arg 1 5 10 <210> SEQ ID NO 609 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 609 Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 10 <210> SEQ ID NO 610 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 610 Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro Arg 1 5 10 <210> SEQ ID NO 611 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 611 Arg Ser Gln Ser Pro Arg Arg Arg 1 5 <210> SEQ ID NO 612 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 612 Arg Ser Gln Ser Pro Arg Arg Arg Arg 1 5 <210> SEQ ID NO 613 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 613 Arg Thr Pro Ser Pro Arg Arg Arg 1 5 <210> SEQ ID NO 614 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 614 Arg Thr Pro Ser Pro Arg Arg Arg Arg 1 5 <210> SEQ ID NO 615 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 615 Arg Val Thr Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 616 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 616 Ser Ala Gly Pro Cys Ala Leu Arg 1 5 <210> SEQ ID NO 617 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 617 Ser Ala Ile Cys Ser Val Val Arg 1 5 <210> SEQ ID NO 618 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 618 Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 619 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 619 Ser Ala Leu Asn Pro Ala Asp Asp Pro Ser Arg 1 5 10 <210> SEQ ID NO 620 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 620 Ser Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 10 <210> SEQ ID NO 621 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 621 Ser Ser Ala Gly Pro Cys Ala Leu Arg 1 5 <210> SEQ ID NO 622 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 622 Ser Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 623 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 623 Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 624 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 624 Ser Thr Asn Arg Gln Ser Gly Arg 1 5 <210> SEQ ID NO 625 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 625 Ser Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 10 <210> SEQ ID NO 626 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 626 Thr Ala Glu Leu Leu Ala Ala Cys Phe Ala Arg 1 5 10 <210> SEQ ID NO 627 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 627 Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 <210> SEQ ID NO 628 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 628 Thr Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 629 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 629 Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg 1 5 10 <210> SEQ ID NO 630 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 630 Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 631 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 631 Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg 1 5 10 <210> SEQ ID NO 632 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 632 Thr Ser Ala Ile Cys Ser Val Val Arg 1 5 <210> SEQ ID NO 633 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 633 Thr Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 10 <210> SEQ ID NO 634 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 634 Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 <210> SEQ ID NO 635 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 635 Thr Thr Ser Thr Gly Pro Cys Lys 1 5 <210> SEQ ID NO 636 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 636 Thr Thr Val Val Arg Arg Arg Gly Arg 1 5 <210> SEQ ID NO 637 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 637 Thr Val Val Arg Arg Arg Gly Arg 1 5 <210> SEQ ID NO 638 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 638 Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg 1 5 10 <210> SEQ ID NO 639 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 639 Val Leu Gly Gly Cys Arg His Lys 1 5 <210> SEQ ID NO 640 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 640 Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg 1 5 10 <210> SEQ ID NO 641 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 641 Val Ser Phe Gly Val Trp Ile Arg 1 5 <210> SEQ ID NO 642 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 642 Val Ser Ile Pro Trp Thr His Lys 1 5 <210> SEQ ID NO 643 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 643 Val Thr Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 644 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 644 Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 <210> SEQ ID NO 645 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 645 Val Val Arg Arg Arg Gly Arg Ser Pro Arg 1 5 10 <210> SEQ ID NO 646 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 646 Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg 1 5 10 <210> SEQ ID NO 647 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 647 Trp Ile Arg Thr Pro Pro Ala Tyr Arg 1 5 <210> SEQ ID NO 648 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 648 Trp Leu Gln Phe Arg Asn Ser Lys 1 5 <210> SEQ ID NO 649 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 649 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr Lys 1 5 10 <210> SEQ ID NO 650 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 650 Tyr Leu Pro Leu Asp Lys Gly Ile Lys 1 5 <210> SEQ ID NO 651 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 651 Tyr Leu Val Ser Phe Gly Val Trp Ile Arg 1 5 10 <210> SEQ ID NO 652 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 652 Tyr Met Asp Asp Val Val Leu Gly Ala Lys 1 5 10 <210> SEQ ID NO 653 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 653 Tyr Ser His Pro Ile Ile Leu Gly Phe Arg 1 5 10 <210> SEQ ID NO 654 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 654 Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys 1 5 10 <210> SEQ ID NO 655 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 655 Ala Phe Pro His Cys Leu Ala Phe 1 5 <210> SEQ ID NO 656 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 656 Ala Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 10 <210> SEQ ID NO 657 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 657 Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met 1 5 10 <210> SEQ ID NO 658 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 658 Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 10 <210> SEQ ID NO 659 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 659 Ala Phe Ser Tyr Met Asp Asp Val Val Leu 1 5 10 <210> SEQ ID NO 660 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 660 Ala Phe Thr Phe Ser Pro Thr Tyr 1 5 <210> SEQ ID NO 661 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 661 Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 10 <210> SEQ ID NO 662 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 662 Ala Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 10 <210> SEQ ID NO 663 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 663 Ala Ile Leu Cys Trp Gly Glu Leu 1 5 <210> SEQ ID NO 664 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 664 Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 665 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 665 Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 666 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 666 Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 <210> SEQ ID NO 667 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 667 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 668 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 668 Ala Thr Pro Thr Gly Trp Gly Leu 1 5 <210> SEQ ID NO 669 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 669 Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 10 <210> SEQ ID NO 670 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 670 Ala Val Pro Asn Leu Gln Ser Leu 1 5 <210> SEQ ID NO 671 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 671 Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu 1 5 10 <210> SEQ ID NO 672 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 672 Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 <210> SEQ ID NO 673 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 673 Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 1 5 10 <210> SEQ ID NO 674 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 674 Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile 1 5 10 <210> SEQ ID NO 675 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 675 Cys Ile Pro Ile Pro Ser Ser Trp 1 5 <210> SEQ ID NO 676 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 676 Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 10 <210> SEQ ID NO 677 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 677 Cys Leu Gly Trp Leu Trp Gly Met 1 5 <210> SEQ ID NO 678 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 678 Cys Leu Gly Trp Leu Trp Gly Met Asp Ile 1 5 10 <210> SEQ ID NO 679 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 679 Cys Leu Ile Phe Leu Leu Val Leu 1 5 <210> SEQ ID NO 680 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 680 Cys Leu Ile Phe Leu Leu Val Leu Leu 1 5 <210> SEQ ID NO 681 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 681 Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 682 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 682 Cys Leu Arg Arg Phe Ile Ile Phe 1 5 <210> SEQ ID NO 683 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 683 Cys Leu Arg Arg Phe Ile Ile Phe Leu 1 5 <210> SEQ ID NO 684 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 684 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 1 5 10 <210> SEQ ID NO 685 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 685 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile 1 5 10 <210> SEQ ID NO 686 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 686 Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp 1 5 10 <210> SEQ ID NO 687 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 687 Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 688 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 688 Asp Leu Leu Asp Thr Ala Ser Ala Leu 1 5 <210> SEQ ID NO 689 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 689 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 690 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 690 Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 10 <210> SEQ ID NO 691 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 691 Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 <210> SEQ ID NO 692 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 692 Asp Trp Lys Val Cys Gln Arg Ile 1 5 <210> SEQ ID NO 693 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 693 Asp Trp Lys Val Cys Gln Arg Ile Val Gly Leu 1 5 10 <210> SEQ ID NO 694 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 694 Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu 1 5 10 <210> SEQ ID NO 695 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 695 Glu Leu Gly Glu Glu Ile Arg Leu 1 5 <210> SEQ ID NO 696 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 696 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 10 <210> SEQ ID NO 697 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 697 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 698 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 698 Glu Tyr Leu Val Ser Phe Gly Val Trp 1 5 <210> SEQ ID NO 699 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 699 Glu Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 10 <210> SEQ ID NO 700 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 700 Phe Phe Cys Leu Trp Val Tyr Ile 1 5 <210> SEQ ID NO 701 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 701 Phe Phe Leu Leu Thr Arg Ile Leu 1 5 <210> SEQ ID NO 702 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 702 Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 10 <210> SEQ ID NO 703 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 703 Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe 1 5 10 <210> SEQ ID NO 704 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 704 Phe Ile Ile Phe Leu Phe Ile Leu 1 5 <210> SEQ ID NO 705 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 705 Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 <210> SEQ ID NO 706 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 706 Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 1 5 10 <210> SEQ ID NO 707 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 707 Phe Ile Leu Leu Leu Cys Leu Ile 1 5 <210> SEQ ID NO 708 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 708 Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 709 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 709 Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 710 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 710 Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 711 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 711 Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 <210> SEQ ID NO 712 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 712 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 10 <210> SEQ ID NO 713 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 713 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 714 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 714 Phe Leu Gly Pro Leu Leu Val Leu 1 5 <210> SEQ ID NO 715 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 715 Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 10 <210> SEQ ID NO 716 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 716 Phe Leu Leu Ser Leu Gly Ile His Leu 1 5 <210> SEQ ID NO 717 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 717 Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 718 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 718 Phe Leu Leu Val Leu Leu Asp Tyr 1 5 <210> SEQ ID NO 719 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 719 Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 720 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 720 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 10 <210> SEQ ID NO 721 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 721 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 10 <210> SEQ ID NO 722 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 722 Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 <210> SEQ ID NO 723 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 723 Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met 1 5 10 <210> SEQ ID NO 724 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 724 Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 <210> SEQ ID NO 725 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 725 Phe Val Gly Leu Ser Pro Thr Val Trp Leu 1 5 10 <210> SEQ ID NO 726 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 726 Phe Val Leu Gly Gly Cys Arg His Lys Leu 1 5 10 <210> SEQ ID NO 727 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 727 Phe Val Gln Trp Phe Val Gly Leu 1 5 <210> SEQ ID NO 728 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 728 Phe Val Tyr Val Pro Ser Ala Leu 1 5 <210> SEQ ID NO 729 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 729 Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 10 <210> SEQ ID NO 730 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 730 Gly Phe Phe Leu Leu Thr Arg Ile 1 5 <210> SEQ ID NO 731 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 731 Gly Phe Phe Leu Leu Thr Arg Ile Leu 1 5 <210> SEQ ID NO 732 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 732 Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 10 <210> SEQ ID NO 733 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 733 Gly Phe Phe Pro Asp His Gln Leu 1 5 <210> SEQ ID NO 734 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 734 Gly Phe Leu Gly Pro Leu Leu Val Leu 1 5 <210> SEQ ID NO 735 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 735 Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu 1 5 10 <210> SEQ ID NO 736 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 736 Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 737 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 737 Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 10 <210> SEQ ID NO 738 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 738 Gly Leu Ser Pro Thr Val Trp Leu 1 5 <210> SEQ ID NO 739 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 739 Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 10 <210> SEQ ID NO 740 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 740 Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 <210> SEQ ID NO 741 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 741 Gly Met Leu Pro Val Cys Pro Leu 1 5 <210> SEQ ID NO 742 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 742 Gly Thr Asp Asn Ser Val Val Leu 1 5 <210> SEQ ID NO 743 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 743 Gly Thr Asn Leu Ser Val Pro Asn Pro Leu 1 5 10 <210> SEQ ID NO 744 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 744 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 10 <210> SEQ ID NO 745 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 745 Gly Val Gly Leu Ser Pro Phe Leu 1 5 <210> SEQ ID NO 746 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 746 Gly Val Gly Leu Ser Pro Phe Leu Leu 1 5 <210> SEQ ID NO 747 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 747 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 10 <210> SEQ ID NO 748 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 748 Gly Trp Leu Trp Gly Met Asp Ile 1 5 <210> SEQ ID NO 749 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 749 Gly Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 10 <210> SEQ ID NO 750 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 750 Gly Trp Ser Pro Gln Ala Gln Gly Ile 1 5 <210> SEQ ID NO 751 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 751 Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu 1 5 10 <210> SEQ ID NO 752 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 752 Gly Tyr Pro Ala Leu Met Pro Leu 1 5 <210> SEQ ID NO 753 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 753 Gly Tyr Pro Ala Leu Met Pro Leu Tyr 1 5 <210> SEQ ID NO 754 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 754 Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 1 5 10 <210> SEQ ID NO 755 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 755 Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile 1 5 10 <210> SEQ ID NO 756 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 756 Gly Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 <210> SEQ ID NO 757 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 757 Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val Ile 1 5 10 <210> SEQ ID NO 758 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 758 His Phe Ala Ser Pro Leu His Val Ala Trp 1 5 10 <210> SEQ ID NO 759 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 759 His Phe Arg Lys Leu Leu Leu Leu 1 5 <210> SEQ ID NO 760 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 760 His Leu Leu Val Gly Ser Ser Gly Leu 1 5 <210> SEQ ID NO 761 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 761 His Leu Asn Pro Asn Lys Thr Lys Arg Trp 1 5 10 <210> SEQ ID NO 762 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 762 His Leu Tyr Ser His Pro Ile Ile 1 5 <210> SEQ ID NO 763 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 763 His Leu Tyr Ser His Pro Ile Ile Leu 1 5 <210> SEQ ID NO 764 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 764 His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 765 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 765 His Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 10 <210> SEQ ID NO 766 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 766 His Thr Ala Leu Arg Gln Ala Ile 1 5 <210> SEQ ID NO 767 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 767 His Thr Ala Leu Arg Gln Ala Ile Leu 1 5 <210> SEQ ID NO 768 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 768 His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 10 <210> SEQ ID NO 769 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 769 His Thr Leu Trp Lys Ala Gly Ile 1 5 <210> SEQ ID NO 770 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 770 His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 <210> SEQ ID NO 771 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 771 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 772 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 772 His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 773 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 773 Ile Phe Phe Cys Leu Trp Val Tyr 1 5 <210> SEQ ID NO 774 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 774 Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 <210> SEQ ID NO 775 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 775 Ile Phe Leu Phe Ile Leu Leu Leu 1 5 <210> SEQ ID NO 776 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 776 Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 10 <210> SEQ ID NO 777 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 777 Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 10 <210> SEQ ID NO 778 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 778 Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 <210> SEQ ID NO 779 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 779 Ile Ile Phe Leu Phe Ile Leu Leu 1 5 <210> SEQ ID NO 780 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 780 Ile Ile Phe Leu Phe Ile Leu Leu Leu 1 5 <210> SEQ ID NO 781 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 781 Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 10 <210> SEQ ID NO 782 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 782 Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 783 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 783 Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 784 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 784 Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 785 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 785 Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 <210> SEQ ID NO 786 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 786 Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 787 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 787 Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 <210> SEQ ID NO 788 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 788 Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 789 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 789 Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 <210> SEQ ID NO 790 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 790 Ile Leu Thr Ile Pro Gln Ser Leu 1 5 <210> SEQ ID NO 791 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 791 Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 792 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 792 Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 10 <210> SEQ ID NO 793 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 793 Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 10 <210> SEQ ID NO 794 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 794 Lys Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 10 <210> SEQ ID NO 795 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 795 Lys Ile Pro Met Gly Val Gly Leu 1 5 <210> SEQ ID NO 796 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 796 Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 10 <210> SEQ ID NO 797 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 797 Lys Leu Cys Leu Gly Trp Leu Trp 1 5 <210> SEQ ID NO 798 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 798 Lys Leu Cys Leu Gly Trp Leu Trp Gly Met 1 5 10 <210> SEQ ID NO 799 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 799 Lys Leu His Leu Tyr Ser His Pro Ile 1 5 <210> SEQ ID NO 800 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 800 Lys Leu His Leu Tyr Ser His Pro Ile Ile 1 5 10 <210> SEQ ID NO 801 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 801 Lys Leu His Leu Tyr Ser His Pro Ile Ile Leu 1 5 10 <210> SEQ ID NO 802 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 802 Lys Leu Ile Met Pro Ala Arg Phe 1 5 <210> SEQ ID NO 803 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 803 Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 804 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 804 Lys Leu Pro Val Asn Arg Pro Ile 1 5 <210> SEQ ID NO 805 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 805 Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 <210> SEQ ID NO 806 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 806 Lys Thr Lys Arg Trp Gly Tyr Ser Leu 1 5 <210> SEQ ID NO 807 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 807 Lys Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 808 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 808 Lys Val Cys Gln Arg Ile Val Gly Leu 1 5 <210> SEQ ID NO 809 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 809 Lys Val Cys Gln Arg Ile Val Gly Leu Leu 1 5 10 <210> SEQ ID NO 810 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 810 Lys Val Gly Asn Phe Thr Gly Leu 1 5 <210> SEQ ID NO 811 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 811 Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 <210> SEQ ID NO 812 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 812 Lys Val Leu His Lys Arg Thr Leu 1 5 <210> SEQ ID NO 813 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 813 Lys Val Leu His Lys Arg Thr Leu Gly Leu 1 5 10 <210> SEQ ID NO 814 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 814 Lys Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 <210> SEQ ID NO 815 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 815 Lys Tyr Thr Ser Phe Pro Trp Leu 1 5 <210> SEQ ID NO 816 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 816 Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 817 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 817 Leu Phe Ile Leu Leu Leu Cys Leu 1 5 <210> SEQ ID NO 818 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 818 Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 <210> SEQ ID NO 819 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 819 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 820 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 820 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 821 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 821 Leu Ile Phe Leu Leu Val Leu Leu 1 5 <210> SEQ ID NO 822 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 822 Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 823 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 823 Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 824 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 824 Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 <210> SEQ ID NO 825 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 825 Leu Leu Cys Leu Ile Phe Leu Leu 1 5 <210> SEQ ID NO 826 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 826 Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 1 5 10 <210> SEQ ID NO 827 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 827 Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu 1 5 10 <210> SEQ ID NO 828 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 828 Leu Leu Asp Thr Ala Ser Ala Leu 1 5 <210> SEQ ID NO 829 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 829 Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 <210> SEQ ID NO 830 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 830 Leu Leu Asp Tyr Gln Gly Met Leu 1 5 <210> SEQ ID NO 831 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 831 Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 832 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 832 Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 <210> SEQ ID NO 833 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 833 Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu 1 5 10 <210> SEQ ID NO 834 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 834 Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 835 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 835 Leu Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile 1 5 10 <210> SEQ ID NO 836 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 836 Leu Leu Leu Cys Leu Ile Phe Leu 1 5 <210> SEQ ID NO 837 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 837 Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 <210> SEQ ID NO 838 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 838 Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 1 5 10 <210> SEQ ID NO 839 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 839 Leu Leu Pro Ile Phe Phe Cys Leu 1 5 <210> SEQ ID NO 840 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 840 Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 <210> SEQ ID NO 841 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 841 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 10 <210> SEQ ID NO 842 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 842 Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 843 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 843 Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 844 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 844 Leu Leu Ser Leu Gly Ile His Leu 1 5 <210> SEQ ID NO 845 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 845 Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 846 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 846 Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 <210> SEQ ID NO 847 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 847 Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu 1 5 10 <210> SEQ ID NO 848 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 848 Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 849 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 849 Leu Leu Val Gly Ser Ser Gly Leu 1 5 <210> SEQ ID NO 850 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 850 Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 851 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 851 Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 10 <210> SEQ ID NO 852 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 852 Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 853 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 853 Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 854 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 854 Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 10 <210> SEQ ID NO 855 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 855 Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 10 <210> SEQ ID NO 856 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 856 Leu Leu Val Pro Phe Val Gln Trp 1 5 <210> SEQ ID NO 857 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 857 Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 858 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 858 Leu Leu Trp Phe His Ile Ser Cys Leu 1 5 <210> SEQ ID NO 859 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 859 Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 10 <210> SEQ ID NO 860 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 860 Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 861 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 861 Leu Thr Phe Gly Arg Glu Thr Val Leu 1 5 <210> SEQ ID NO 862 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 862 Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 10 <210> SEQ ID NO 863 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 863 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 864 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 864 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 865 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 865 Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 <210> SEQ ID NO 866 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 866 Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 10 <210> SEQ ID NO 867 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 867 Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 <210> SEQ ID NO 868 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 868 Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 869 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 869 Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 870 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 870 Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 10 <210> SEQ ID NO 871 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 871 Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 872 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 872 Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 <210> SEQ ID NO 873 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 873 Leu Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 10 <210> SEQ ID NO 874 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 874 Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 875 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 875 Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 10 <210> SEQ ID NO 876 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 876 Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 877 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 877 Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 878 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 878 Leu Trp Phe His Ile Ser Cys Leu 1 5 <210> SEQ ID NO 879 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 879 Leu Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 10 <210> SEQ ID NO 880 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 880 Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 <210> SEQ ID NO 881 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 881 Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 882 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 882 Leu Tyr Ser His Pro Ile Ile Leu 1 5 <210> SEQ ID NO 883 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 883 Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 884 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 884 Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 <210> SEQ ID NO 885 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 885 Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 886 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 886 Met Trp Tyr Trp Gly Pro Ser Leu 1 5 <210> SEQ ID NO 887 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 887 Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 <210> SEQ ID NO 888 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 888 Asn Phe Leu Leu Ser Leu Gly Ile 1 5 <210> SEQ ID NO 889 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 889 Asn Phe Leu Leu Ser Leu Gly Ile His Leu 1 5 10 <210> SEQ ID NO 890 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 890 Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 <210> SEQ ID NO 891 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 891 Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp 1 5 10 <210> SEQ ID NO 892 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 892 Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 893 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 893 Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 10 <210> SEQ ID NO 894 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 894 Asn Leu Asn Val Ser Ile Pro Trp 1 5 <210> SEQ ID NO 895 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 895 Asn Leu Gln Ser Leu Thr Asn Leu 1 5 <210> SEQ ID NO 896 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 896 Asn Leu Gln Ser Leu Thr Asn Leu Leu 1 5 <210> SEQ ID NO 897 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 897 Asn Leu Ser Val Pro Asn Pro Leu 1 5 <210> SEQ ID NO 898 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 898 Asn Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 10 <210> SEQ ID NO 899 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 899 Asn Trp Ile Leu Arg Gly Thr Ser Phe 1 5 <210> SEQ ID NO 900 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 900 Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 10 <210> SEQ ID NO 901 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 901 Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 10 <210> SEQ ID NO 902 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 902 Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 10 <210> SEQ ID NO 903 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 903 Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met 1 5 10 <210> SEQ ID NO 904 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 904 Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 <210> SEQ ID NO 905 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 905 Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 10 <210> SEQ ID NO 906 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 906 Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 <210> SEQ ID NO 907 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 907 Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 10 <210> SEQ ID NO 908 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 908 Pro Ile His Thr Ala Glu Leu Leu 1 5 <210> SEQ ID NO 909 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 909 Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 910 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 910 Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 911 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 911 Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 912 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 912 Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 <210> SEQ ID NO 913 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 913 Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 914 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 914 Pro Leu Glu Glu Glu Leu Pro Arg Leu 1 5 <210> SEQ ID NO 915 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 915 Pro Leu Gly Phe Phe Pro Asp His Gln Leu 1 5 10 <210> SEQ ID NO 916 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 916 Pro Leu His Pro Ala Ala Met Pro His Leu 1 5 10 <210> SEQ ID NO 917 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 917 Pro Leu His Pro Ala Ala Met Pro His Leu Leu 1 5 10 <210> SEQ ID NO 918 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 918 Pro Leu Leu Pro Ile Phe Phe Cys Leu 1 5 <210> SEQ ID NO 919 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 919 Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 10 <210> SEQ ID NO 920 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 920 Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 921 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 921 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 922 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 922 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 10 <210> SEQ ID NO 923 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 923 Pro Leu Pro Ile His Thr Ala Glu Leu 1 5 <210> SEQ ID NO 924 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 924 Pro Leu Pro Ile His Thr Ala Glu Leu Leu 1 5 10 <210> SEQ ID NO 925 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 925 Pro Leu Ser Tyr Gln His Phe Arg Lys Leu 1 5 10 <210> SEQ ID NO 926 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 926 Pro Leu Ser Tyr Gln His Phe Arg Lys Leu Leu 1 5 10 <210> SEQ ID NO 927 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 927 Pro Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 10 <210> SEQ ID NO 928 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 928 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 929 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 929 Pro Met Gly Val Gly Leu Ser Pro Phe Leu 1 5 10 <210> SEQ ID NO 930 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 930 Pro Met Gly Val Gly Leu Ser Pro Phe Leu Leu 1 5 10 <210> SEQ ID NO 931 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 931 Pro Thr Gly Trp Gly Leu Ala Ile 1 5 <210> SEQ ID NO 932 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 932 Pro Thr Thr Gly Arg Thr Ser Leu 1 5 <210> SEQ ID NO 933 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 933 Pro Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 934 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 934 Pro Thr Val Gln Ala Ser Lys Leu 1 5 <210> SEQ ID NO 935 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 935 Pro Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 10 <210> SEQ ID NO 936 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 936 Pro Thr Val Trp Leu Ser Val Ile 1 5 <210> SEQ ID NO 937 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 937 Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 938 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 938 Pro Thr Val Trp Leu Ser Val Ile Trp Met 1 5 10 <210> SEQ ID NO 939 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 939 Pro Val Asn Arg Pro Ile Asp Trp 1 5 <210> SEQ ID NO 940 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 940 Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 10 <210> SEQ ID NO 941 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 941 Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 10 <210> SEQ ID NO 942 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 942 Pro Trp Thr His Lys Val Gly Asn Phe 1 5 <210> SEQ ID NO 943 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 943 Gln Leu Asp Pro Ala Arg Asp Val Leu 1 5 <210> SEQ ID NO 944 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 944 Gln Leu Asp Pro Ala Arg Asp Val Leu Cys Leu 1 5 10 <210> SEQ ID NO 945 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 945 Gln Leu Leu Trp Phe His Ile Ser Cys Leu 1 5 10 <210> SEQ ID NO 946 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 946 Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 10 <210> SEQ ID NO 947 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 947 Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 10 <210> SEQ ID NO 948 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 948 Arg Phe Ile Ile Phe Leu Phe Ile 1 5 <210> SEQ ID NO 949 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 949 Arg Phe Ile Ile Phe Leu Phe Ile Leu 1 5 <210> SEQ ID NO 950 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 950 Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 10 <210> SEQ ID NO 951 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 951 Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 1 5 10 <210> SEQ ID NO 952 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 952 Arg Phe Ser Trp Leu Ser Leu Leu 1 5 <210> SEQ ID NO 953 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 953 Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 10 <210> SEQ ID NO 954 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 954 Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 <210> SEQ ID NO 955 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 955 Arg Ile Val Gly Leu Leu Gly Phe 1 5 <210> SEQ ID NO 956 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 956 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 10 <210> SEQ ID NO 957 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 957 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 10 <210> SEQ ID NO 958 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 958 Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 959 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 959 Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 960 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 960 Arg Val Ala Glu Asp Leu Asn Leu 1 5 <210> SEQ ID NO 961 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 961 Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu 1 5 10 <210> SEQ ID NO 962 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 962 Arg Val His Phe Ala Ser Pro Leu 1 5 <210> SEQ ID NO 963 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 963 Arg Val Thr Gly Gly Val Phe Leu 1 5 <210> SEQ ID NO 964 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 964 Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 965 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 965 Arg Trp Gly Tyr Ser Leu Asn Phe Met 1 5 <210> SEQ ID NO 966 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 966 Arg Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 10 <210> SEQ ID NO 967 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 967 Arg Trp Met Cys Leu Arg Arg Phe 1 5 <210> SEQ ID NO 968 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 968 Arg Trp Met Cys Leu Arg Arg Phe Ile 1 5 <210> SEQ ID NO 969 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 969 Arg Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 10 <210> SEQ ID NO 970 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 970 Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 971 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 971 Ser Phe Cys Gly Ser Pro Tyr Ser Trp 1 5 <210> SEQ ID NO 972 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 972 Ser Phe Leu Pro Ser Asp Phe Phe 1 5 <210> SEQ ID NO 973 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 973 Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 <210> SEQ ID NO 974 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 974 Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 <210> SEQ ID NO 975 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 975 Ser Leu Asp Ser Trp Trp Thr Ser Leu 1 5 <210> SEQ ID NO 976 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 976 Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 977 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 977 Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 978 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 978 Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 <210> SEQ ID NO 979 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 979 Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 <210> SEQ ID NO 980 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 980 Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 981 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 981 Ser Leu Asn Phe Met Gly Tyr Val Ile 1 5 <210> SEQ ID NO 982 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 982 Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 983 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 983 Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 10 <210> SEQ ID NO 984 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 984 Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 985 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 985 Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 986 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 986 Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 987 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 987 Ser Val Gln His Leu Glu Ser Leu 1 5 <210> SEQ ID NO 988 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 988 Ser Val Arg Phe Ser Trp Leu Ser Leu 1 5 <210> SEQ ID NO 989 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 989 Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 1 5 10 <210> SEQ ID NO 990 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 990 Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 991 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 991 Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 992 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 992 Ser Val Val Arg Arg Ala Phe Pro His Cys Leu 1 5 10 <210> SEQ ID NO 993 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 993 Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 <210> SEQ ID NO 994 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 994 Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 995 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 995 Ser Trp Pro Lys Phe Ala Val Pro Asn Leu 1 5 10 <210> SEQ ID NO 996 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 996 Ser Trp Trp Thr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 997 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 997 Ser Trp Trp Thr Ser Leu Asn Phe Leu 1 5 <210> SEQ ID NO 998 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 998 Ser Tyr Met Asp Asp Val Val Leu 1 5 <210> SEQ ID NO 999 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 999 Ser Tyr Gln His Phe Arg Lys Leu 1 5 <210> SEQ ID NO 1000 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1000 Ser Tyr Gln His Phe Arg Lys Leu Leu 1 5 <210> SEQ ID NO 1001 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1001 Ser Tyr Gln His Phe Arg Lys Leu Leu Leu 1 5 10 <210> SEQ ID NO 1002 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1002 Ser Tyr Gln His Phe Arg Lys Leu Leu Leu Leu 1 5 10 <210> SEQ ID NO 1003 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1003 Thr Phe Gly Arg Glu Thr Val Leu 1 5 <210> SEQ ID NO 1004 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1004 Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 10 <210> SEQ ID NO 1005 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1005 Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu 1 5 10 <210> SEQ ID NO 1006 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1006 Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 <210> SEQ ID NO 1007 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1007 Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 10 <210> SEQ ID NO 1008 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1008 Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 <210> SEQ ID NO 1009 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1009 Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 1010 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1010 Thr Leu Trp Lys Ala Gly Ile Leu 1 5 <210> SEQ ID NO 1011 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1011 Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 1012 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1012 Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 1013 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1013 Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 1014 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1014 Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 1015 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1015 Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 <210> SEQ ID NO 1016 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1016 Thr Val Gln Ala Ser Lys Leu Cys Leu Gly Trp 1 5 10 <210> SEQ ID NO 1017 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1017 Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 1018 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1018 Thr Val Trp Leu Ser Val Ile Trp Met 1 5 <210> SEQ ID NO 1019 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1019 Val Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 10 <210> SEQ ID NO 1020 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1020 Val Phe Val Leu Gly Gly Cys Arg His Lys Leu 1 5 10 <210> SEQ ID NO 1021 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1021 Val Leu Gly Ala Lys Ser Val Gln His Leu 1 5 10 <210> SEQ ID NO 1022 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1022 Val Leu Gly Gly Cys Arg His Lys Leu 1 5 <210> SEQ ID NO 1023 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1023 Val Leu His Lys Arg Thr Leu Gly Leu 1 5 <210> SEQ ID NO 1024 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1024 Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 1025 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1025 Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 <210> SEQ ID NO 1026 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1026 Val Leu Gln Ala Gly Phe Phe Leu 1 5 <210> SEQ ID NO 1027 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1027 Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 <210> SEQ ID NO 1028 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1028 Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 1029 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1029 Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 10 <210> SEQ ID NO 1030 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1030 Val Val Leu Gly Ala Lys Ser Val Gln His Leu 1 5 10 <210> SEQ ID NO 1031 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1031 Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 1032 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1032 Val Val Arg Arg Ala Phe Pro His Cys Leu 1 5 10 <210> SEQ ID NO 1033 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1033 Val Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 <210> SEQ ID NO 1034 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1034 Val Trp Leu Ser Val Ile Trp Met 1 5 <210> SEQ ID NO 1035 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1035 Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 1036 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1036 Trp Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 10 <210> SEQ ID NO 1037 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1037 Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 1 5 10 <210> SEQ ID NO 1038 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1038 Trp Ile Leu Arg Gly Thr Ser Phe 1 5 <210> SEQ ID NO 1039 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1039 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 10 <210> SEQ ID NO 1040 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1040 Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 <210> SEQ ID NO 1041 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1041 Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 1042 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1042 Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 10 <210> SEQ ID NO 1043 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1043 Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu 1 5 10 <210> SEQ ID NO 1044 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1044 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 <210> SEQ ID NO 1045 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1045 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 1046 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1046 Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 1047 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1047 Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 10 <210> SEQ ID NO 1048 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1048 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 10 <210> SEQ ID NO 1049 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1049 Trp Met Cys Leu Arg Arg Phe Ile 1 5 <210> SEQ ID NO 1050 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1050 Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 <210> SEQ ID NO 1051 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1051 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 1052 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1052 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu 1 5 10 <210> SEQ ID NO 1053 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1053 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 10 <210> SEQ ID NO 1054 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1054 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 1055 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1055 Trp Thr His Lys Val Gly Asn Phe 1 5 <210> SEQ ID NO 1056 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1056 Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu 1 5 10 <210> SEQ ID NO 1057 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1057 Trp Trp Thr Ser Leu Asn Phe Leu 1 5 <210> SEQ ID NO 1058 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1058 Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 <210> SEQ ID NO 1059 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1059 Tyr Leu His Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 1060 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1060 Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 10 <210> SEQ ID NO 1061 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1061 Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 <210> SEQ ID NO 1062 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1062 Tyr Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 10 <210> SEQ ID NO 1063 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1063 Tyr Leu Val Ser Phe Gly Val Trp 1 5 <210> SEQ ID NO 1064 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1064 Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 1065 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1065 Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 1066 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1066 Ala Pro Cys Asn Phe Phe Thr Ser Ala 1 5 <210> SEQ ID NO 1067 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1067 Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 <210> SEQ ID NO 1068 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1068 Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala 1 5 10 <210> SEQ ID NO 1069 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1069 Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 10 <210> SEQ ID NO 1070 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1070 Cys Pro Gly Tyr Arg Trp Met Cys Leu 1 5 <210> SEQ ID NO 1071 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1071 Cys Pro Thr Val Gln Ala Ser Lys Leu 1 5 <210> SEQ ID NO 1072 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1072 Cys Pro Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 10 <210> SEQ ID NO 1073 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1073 Asp Pro Ala Arg Asp Val Leu Cys Leu 1 5 <210> SEQ ID NO 1074 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1074 Asp Pro Arg Val Arg Gly Leu Tyr 1 5 <210> SEQ ID NO 1075 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1075 Asp Pro Ser Arg Gly Arg Leu Gly Leu 1 5 <210> SEQ ID NO 1076 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1076 Asp Pro Tyr Lys Glu Phe Gly Ala 1 5 <210> SEQ ID NO 1077 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1077 Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 1 5 10 <210> SEQ ID NO 1078 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1078 Phe Pro Asp His Gln Leu Asp Pro Ala 1 5 <210> SEQ ID NO 1079 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1079 Phe Pro Asp His Gln Leu Asp Pro Ala Phe 1 5 10 <210> SEQ ID NO 1080 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1080 Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 1081 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1081 Phe Pro His Cys Leu Ala Phe Ser Tyr Met 1 5 10 <210> SEQ ID NO 1082 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1082 Phe Pro Trp Leu Leu Gly Cys Ala 1 5 <210> SEQ ID NO 1083 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1083 Phe Pro Trp Leu Leu Gly Cys Ala Ala 1 5 <210> SEQ ID NO 1084 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1084 Phe Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 10 <210> SEQ ID NO 1085 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1085 Gly Pro Cys Ala Leu Arg Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 1086 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1086 Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu 1 5 10 <210> SEQ ID NO 1087 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1087 Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala 1 5 10 <210> SEQ ID NO 1088 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1088 Gly Pro Leu Leu Val Leu Gln Ala 1 5 <210> SEQ ID NO 1089 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1089 Gly Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 10 <210> SEQ ID NO 1090 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1090 Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 1091 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1091 Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 10 <210> SEQ ID NO 1092 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1092 His Pro Ala Ala Met Pro His Leu 1 5 <210> SEQ ID NO 1093 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1093 His Pro Ala Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 1094 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1094 His Pro Ala Ala Met Pro His Leu Leu Val 1 5 10 <210> SEQ ID NO 1095 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1095 His Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 10 <210> SEQ ID NO 1096 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1096 Ile Pro Ile Pro Ser Ser Trp Ala 1 5 <210> SEQ ID NO 1097 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1097 Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 1098 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1098 Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala 1 5 10 <210> SEQ ID NO 1099 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1099 Ile Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 10 <210> SEQ ID NO 1100 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1100 Ile Pro Met Gly Val Gly Leu Ser Pro Phe Leu 1 5 10 <210> SEQ ID NO 1101 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1101 Ile Pro Gln Ser Leu Asp Ser Trp 1 5 <210> SEQ ID NO 1102 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1102 Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 <210> SEQ ID NO 1103 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1103 Ile Pro Ser Ser Trp Ala Phe Ala 1 5 <210> SEQ ID NO 1104 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1104 Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 <210> SEQ ID NO 1105 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1105 Leu Pro Ile Phe Phe Cys Leu Trp 1 5 <210> SEQ ID NO 1106 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1106 Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 <210> SEQ ID NO 1107 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1107 Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 10 <210> SEQ ID NO 1108 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1108 Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 10 <210> SEQ ID NO 1109 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1109 Leu Pro Ile His Thr Ala Glu Leu 1 5 <210> SEQ ID NO 1110 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1110 Leu Pro Ile His Thr Ala Glu Leu Leu 1 5 <210> SEQ ID NO 1111 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1111 Leu Pro Ile His Thr Ala Glu Leu Leu Ala 1 5 10 <210> SEQ ID NO 1112 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1112 Leu Pro Ile His Thr Ala Glu Leu Leu Ala Ala 1 5 10 <210> SEQ ID NO 1113 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1113 Leu Pro Lys Val Leu His Lys Arg Thr Leu 1 5 10 <210> SEQ ID NO 1114 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1114 Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 10 <210> SEQ ID NO 1115 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1115 Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 1116 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1116 Leu Pro Val Cys Ala Phe Ser Ser Ala 1 5 <210> SEQ ID NO 1117 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1117 Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 <210> SEQ ID NO 1118 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1118 Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val 1 5 10 <210> SEQ ID NO 1119 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1119 Met Pro His Leu Leu Val Gly Ser Ser Gly Leu 1 5 10 <210> SEQ ID NO 1120 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1120 Met Pro Leu Ser Tyr Gln His Phe 1 5 <210> SEQ ID NO 1121 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1121 Met Pro Leu Ser Tyr Gln His Phe Arg Lys Leu 1 5 10 <210> SEQ ID NO 1122 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1122 Asn Pro Ala Asp Asp Pro Ser Arg Gly Arg Leu 1 5 10 <210> SEQ ID NO 1123 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1123 Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu 1 5 10 <210> SEQ ID NO 1124 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1124 Asn Pro Asn Lys Thr Lys Arg Trp 1 5 <210> SEQ ID NO 1125 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1125 Asn Pro Asn Lys Thr Lys Arg Trp Gly Tyr 1 5 10 <210> SEQ ID NO 1126 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1126 Pro Pro Ala Tyr Arg Pro Pro Asn Ala 1 5 <210> SEQ ID NO 1127 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1127 Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 10 <210> SEQ ID NO 1128 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1128 Pro Pro His Gly Gly Leu Leu Gly Trp 1 5 <210> SEQ ID NO 1129 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1129 Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu 1 5 10 <210> SEQ ID NO 1130 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1130 Arg Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 10 <210> SEQ ID NO 1131 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1131 Arg Pro Pro Asn Ala Pro Ile Leu 1 5 <210> SEQ ID NO 1132 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1132 Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu 1 5 10 <210> SEQ ID NO 1133 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1133 Ser Pro Glu His Cys Ser Pro His His Thr Ala 1 5 10 <210> SEQ ID NO 1134 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1134 Ser Pro Phe Leu Leu Ala Gln Phe 1 5 <210> SEQ ID NO 1135 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1135 Ser Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 1136 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1136 Ser Pro His His Thr Ala Leu Arg Gln Ala 1 5 10 <210> SEQ ID NO 1137 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1137 Ser Pro His His Thr Ala Leu Arg Gln Ala Ile 1 5 10 <210> SEQ ID NO 1138 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1138 Ser Pro Gln Ala Gln Gly Ile Leu 1 5 <210> SEQ ID NO 1139 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1139 Ser Pro Ser Val Pro Ser His Leu 1 5 <210> SEQ ID NO 1140 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1140 Ser Pro Thr Val Trp Leu Ser Val 1 5 <210> SEQ ID NO 1141 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1141 Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 <210> SEQ ID NO 1142 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1142 Ser Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 10 <210> SEQ ID NO 1143 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1143 Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met 1 5 10 <210> SEQ ID NO 1144 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1144 Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 <210> SEQ ID NO 1145 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1145 Thr Pro Ala Arg Val Thr Gly Gly Val 1 5 <210> SEQ ID NO 1146 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1146 Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 1147 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1147 Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu 1 5 10 <210> SEQ ID NO 1148 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1148 Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala 1 5 10 <210> SEQ ID NO 1149 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1149 Thr Pro Pro His Gly Gly Leu Leu 1 5 <210> SEQ ID NO 1150 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1150 Thr Pro Pro His Gly Gly Leu Leu Gly Trp 1 5 10 <210> SEQ ID NO 1151 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1151 Thr Pro Thr Gly Trp Gly Leu Ala 1 5 <210> SEQ ID NO 1152 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1152 Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 <210> SEQ ID NO 1153 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1153 Val Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 1154 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1154 Val Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 10 <210> SEQ ID NO 1155 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1155 Val Pro Asn Leu Gln Ser Leu Thr Asn Leu 1 5 10 <210> SEQ ID NO 1156 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1156 Val Pro Asn Leu Gln Ser Leu Thr Asn Leu Leu 1 5 10 <210> SEQ ID NO 1157 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1157 Val Pro Ser Ala Leu Asn Pro Ala 1 5 <210> SEQ ID NO 1158 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1158 Trp Pro Lys Phe Ala Val Pro Asn Leu 1 5 <210> SEQ ID NO 1159 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1159 Tyr Pro Ala Leu Met Pro Leu Tyr 1 5 <210> SEQ ID NO 1160 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1160 Tyr Pro Ala Leu Met Pro Leu Tyr Ala 1 5 <210> SEQ ID NO 1161 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1161 Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 10 <210> SEQ ID NO 1162 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1162 Ala His Leu Ser Leu Arg Gly Leu 1 5 <210> SEQ ID NO 1163 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1163 Ala Lys Ser Val Gln His Leu Glu Ser Leu 1 5 10 <210> SEQ ID NO 1164 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1164 Ala Arg Val Thr Gly Gly Val Phe 1 5 <210> SEQ ID NO 1165 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1165 Ala Arg Val Thr Gly Gly Val Phe Leu 1 5 <210> SEQ ID NO 1166 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1166 Asp His Gly Ala His Leu Ser Leu 1 5 <210> SEQ ID NO 1167 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1167 Asp His Gly Ala His Leu Ser Leu Arg Gly Leu 1 5 10 <210> SEQ ID NO 1168 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1168 Asp His Gln Leu Asp Pro Ala Phe 1 5 <210> SEQ ID NO 1169 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1169 Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 <210> SEQ ID NO 1170 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1170 Glu His Cys Ser Pro His His Thr Ala Leu 1 5 10 <210> SEQ ID NO 1171 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1171 Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 1172 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1172 Phe Arg Lys Ile Pro Met Gly Val Gly Leu 1 5 10 <210> SEQ ID NO 1173 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1173 Phe Arg Lys Leu Pro Val Asn Arg Pro Ile 1 5 10 <210> SEQ ID NO 1174 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1174 Gly Arg Glu Thr Val Leu Glu Tyr 1 5 <210> SEQ ID NO 1175 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1175 Gly Arg Glu Thr Val Leu Glu Tyr Leu 1 5 <210> SEQ ID NO 1176 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1176 His His Thr Ala Leu Arg Gln Ala Ile 1 5 <210> SEQ ID NO 1177 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1177 His His Thr Ala Leu Arg Gln Ala Ile Leu 1 5 10 <210> SEQ ID NO 1178 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1178 His Lys Val Gly Asn Phe Thr Gly Leu 1 5 <210> SEQ ID NO 1179 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1179 His Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 10 <210> SEQ ID NO 1180 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1180 Ile His Leu Asn Pro Asn Lys Thr Lys Arg Trp 1 5 10 <210> SEQ ID NO 1181 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1181 Ile His Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 10 <210> SEQ ID NO 1182 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1182 Lys Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 1183 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1183 Lys Arg Trp Gly Tyr Ser Leu Asn Phe Met 1 5 10 <210> SEQ ID NO 1184 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1184 Leu His Lys Arg Thr Leu Gly Leu 1 5 <210> SEQ ID NO 1185 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1185 Leu His Leu Tyr Ser His Pro Ile 1 5 <210> SEQ ID NO 1186 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1186 Leu His Leu Tyr Ser His Pro Ile Ile 1 5 <210> SEQ ID NO 1187 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1187 Leu His Leu Tyr Ser His Pro Ile Ile Leu 1 5 10 <210> SEQ ID NO 1188 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1188 Leu His Pro Ala Ala Met Pro His Leu 1 5 <210> SEQ ID NO 1189 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1189 Leu His Pro Ala Ala Met Pro His Leu Leu 1 5 10 <210> SEQ ID NO 1190 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1190 Leu His Thr Leu Trp Lys Ala Gly Ile 1 5 <210> SEQ ID NO 1191 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1191 Leu His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 10 <210> SEQ ID NO 1192 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1192 Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 1193 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1193 Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 <210> SEQ ID NO 1194 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1194 Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 10 <210> SEQ ID NO 1195 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1195 Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 <210> SEQ ID NO 1196 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1196 Leu Arg Gly Thr Ser Phe Val Tyr 1 5 <210> SEQ ID NO 1197 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1197 Leu Arg Gln Ala Ile Leu Cys Trp 1 5 <210> SEQ ID NO 1198 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1198 Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu 1 5 10 <210> SEQ ID NO 1199 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1199 Leu Arg Arg Phe Ile Ile Phe Leu 1 5 <210> SEQ ID NO 1200 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1200 Leu Arg Arg Phe Ile Ile Phe Leu Phe 1 5 <210> SEQ ID NO 1201 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1201 Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile 1 5 10 <210> SEQ ID NO 1202 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1202 Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu 1 5 10 <210> SEQ ID NO 1203 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1203 Asn Lys Thr Lys Arg Trp Gly Tyr 1 5 <210> SEQ ID NO 1204 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1204 Asn Lys Thr Lys Arg Trp Gly Tyr Ser Leu 1 5 10 <210> SEQ ID NO 1205 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1205 Asn Arg Arg Val Ala Glu Asp Leu 1 5 <210> SEQ ID NO 1206 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1206 Asn Arg Arg Val Ala Glu Asp Leu Asn Leu 1 5 10 <210> SEQ ID NO 1207 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1207 Pro His Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 1208 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1208 Pro His Cys Leu Ala Phe Ser Tyr Met 1 5 <210> SEQ ID NO 1209 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1209 Pro His Gly Gly Leu Leu Gly Trp 1 5 <210> SEQ ID NO 1210 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1210 Pro His His Thr Ala Leu Arg Gln Ala Ile 1 5 10 <210> SEQ ID NO 1211 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1211 Pro His His Thr Ala Leu Arg Gln Ala Ile Leu 1 5 10 <210> SEQ ID NO 1212 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1212 Pro His Leu Leu Val Gly Ser Ser Gly Leu 1 5 10 <210> SEQ ID NO 1213 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1213 Pro Lys Phe Ala Val Pro Asn Leu 1 5 <210> SEQ ID NO 1214 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1214 Pro Lys Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 10 <210> SEQ ID NO 1215 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1215 Pro Lys Val Leu His Lys Arg Thr Leu 1 5 <210> SEQ ID NO 1216 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1216 Pro Lys Val Leu His Lys Arg Thr Leu Gly Leu 1 5 10 <210> SEQ ID NO 1217 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1217 Gln His Phe Arg Lys Leu Leu Leu 1 5 <210> SEQ ID NO 1218 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1218 Gln His Phe Arg Lys Leu Leu Leu Leu 1 5 <210> SEQ ID NO 1219 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1219 Gln Arg Ile Val Gly Leu Leu Gly Phe 1 5 <210> SEQ ID NO 1220 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1220 Arg His Tyr Leu His Thr Leu Trp 1 5 <210> SEQ ID NO 1221 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1221 Arg Lys Ile Pro Met Gly Val Gly Leu 1 5 <210> SEQ ID NO 1222 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1222 Arg Lys Leu Pro Val Asn Arg Pro Ile 1 5 <210> SEQ ID NO 1223 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1223 Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 <210> SEQ ID NO 1224 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1224 Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 <210> SEQ ID NO 1225 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1225 Arg Lys Tyr Thr Ser Phe Pro Trp Leu 1 5 <210> SEQ ID NO 1226 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1226 Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 10 <210> SEQ ID NO 1227 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1227 Arg Arg Ala Phe Pro His Cys Leu 1 5 <210> SEQ ID NO 1228 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1228 Arg Arg Ala Phe Pro His Cys Leu Ala Phe 1 5 10 <210> SEQ ID NO 1229 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1229 Arg Arg Phe Ile Ile Phe Leu Phe 1 5 <210> SEQ ID NO 1230 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1230 Arg Arg Phe Ile Ile Phe Leu Phe Ile 1 5 <210> SEQ ID NO 1231 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1231 Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu 1 5 10 <210> SEQ ID NO 1232 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1232 Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 10 <210> SEQ ID NO 1233 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1233 Arg Arg Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 10 <210> SEQ ID NO 1234 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1234 Arg Arg Val Ala Glu Asp Leu Asn Leu 1 5 <210> SEQ ID NO 1235 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1235 Ser His Pro Ile Ile Leu Gly Phe 1 5 <210> SEQ ID NO 1236 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1236 Ser His Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 10 <210> SEQ ID NO 1237 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1237 Ser Lys Leu Cys Leu Gly Trp Leu 1 5 <210> SEQ ID NO 1238 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1238 Ser Lys Leu Cys Leu Gly Trp Leu Trp 1 5 <210> SEQ ID NO 1239 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1239 Ser Lys Leu Cys Leu Gly Trp Leu Trp Gly Met 1 5 10 <210> SEQ ID NO 1240 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1240 Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 <210> SEQ ID NO 1241 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1241 Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu 1 5 10 <210> SEQ ID NO 1242 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1242 Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 10 <210> SEQ ID NO 1243 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1243 Ser Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 10 <210> SEQ ID NO 1244 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1244 Ser Arg Asn Leu Tyr Val Ser Leu 1 5 <210> SEQ ID NO 1245 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1245 Thr His Lys Val Gly Asn Phe Thr Gly Leu 1 5 10 <210> SEQ ID NO 1246 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1246 Thr His Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 10 <210> SEQ ID NO 1247 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1247 Thr Lys Arg Trp Gly Tyr Ser Leu 1 5 <210> SEQ ID NO 1248 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1248 Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 1249 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1249 Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe Met 1 5 10 <210> SEQ ID NO 1250 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1250 Thr Lys Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 10 <210> SEQ ID NO 1251 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1251 Thr Arg His Tyr Leu His Thr Leu 1 5 <210> SEQ ID NO 1252 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1252 Thr Arg His Tyr Leu His Thr Leu Trp 1 5 <210> SEQ ID NO 1253 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1253 Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 <210> SEQ ID NO 1254 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1254 Val His Phe Ala Ser Pro Leu His Val Ala Trp 1 5 10 <210> SEQ ID NO 1255 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1255 Val Arg Phe Ser Trp Leu Ser Leu 1 5 <210> SEQ ID NO 1256 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1256 Val Arg Phe Ser Trp Leu Ser Leu Leu 1 5 <210> SEQ ID NO 1257 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1257 Val Arg Arg Ala Phe Pro His Cys Leu 1 5 <210> SEQ ID NO 1258 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1258 Val Arg Arg Ala Phe Pro His Cys Leu Ala Phe 1 5 10 <210> SEQ ID NO 1259 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1259 Trp Lys Val Cys Gln Arg Ile Val Gly Leu 1 5 10 <210> SEQ ID NO 1260 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1260 Trp Lys Val Cys Gln Arg Ile Val Gly Leu Leu 1 5 10 <210> SEQ ID NO 1261 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1261 Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 <210> SEQ ID NO 1262 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1262 Tyr Arg Pro Pro Asn Ala Pro Ile Leu 1 5 <210> SEQ ID NO 1263 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1263 Tyr Arg Trp Met Cys Leu Arg Arg Phe 1 5 <210> SEQ ID NO 1264 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1264 Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile 1 5 10 <210> SEQ ID NO 1265 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1265 Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 10 <210> SEQ ID NO 1266 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1266 Ala Asp Ala Thr Pro Thr Gly Trp 1 5 <210> SEQ ID NO 1267 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1267 Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 <210> SEQ ID NO 1268 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1268 Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu Ala 1 5 10 <210> SEQ ID NO 1269 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1269 Ala Asp Asp Pro Ser Arg Gly Arg Leu 1 5 <210> SEQ ID NO 1270 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1270 Ala Asp Asp Pro Ser Arg Gly Arg Leu Gly Leu 1 5 10 <210> SEQ ID NO 1271 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1271 Ala Glu Asp Leu Asn Leu Gly Asn Leu 1 5 <210> SEQ ID NO 1272 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1272 Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val 1 5 10 <210> SEQ ID NO 1273 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1273 Ala Glu Leu Leu Ala Ala Cys Phe 1 5 <210> SEQ ID NO 1274 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1274 Ala Glu Leu Leu Ala Ala Cys Phe Ala 1 5 <210> SEQ ID NO 1275 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1275 Asp Asp Pro Ser Arg Gly Arg Leu 1 5 <210> SEQ ID NO 1276 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1276 Asp Asp Pro Ser Arg Gly Arg Leu Gly Leu 1 5 10 <210> SEQ ID NO 1277 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1277 Asp Asp Val Val Leu Gly Ala Lys Ser Val 1 5 10 <210> SEQ ID NO 1278 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1278 Asp Glu Ala Gly Pro Leu Glu Glu Glu Leu 1 5 10 <210> SEQ ID NO 1279 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1279 Glu Asp Leu Asn Leu Gly Asn Leu 1 5 <210> SEQ ID NO 1280 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1280 Glu Asp Leu Asn Leu Gly Asn Leu Asn Val 1 5 10 <210> SEQ ID NO 1281 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1281 Glu Glu Glu Leu Pro Arg Leu Ala 1 5 <210> SEQ ID NO 1282 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1282 Glu Glu Leu Gly Glu Glu Ile Arg Leu 1 5 <210> SEQ ID NO 1283 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1283 Ile Asp Pro Tyr Lys Glu Phe Gly Ala 1 5 <210> SEQ ID NO 1284 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1284 Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 <210> SEQ ID NO 1285 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1285 Ile Asp Trp Lys Val Cys Gln Arg Ile Val 1 5 10 <210> SEQ ID NO 1286 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1286 Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 <210> SEQ ID NO 1287 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1287 Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 <210> SEQ ID NO 1288 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1288 Leu Asp Pro Ala Arg Asp Val Leu 1 5 <210> SEQ ID NO 1289 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1289 Leu Asp Pro Ala Arg Asp Val Leu Cys Leu 1 5 10 <210> SEQ ID NO 1290 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1290 Leu Asp Ser Trp Trp Thr Ser Leu 1 5 <210> SEQ ID NO 1291 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1291 Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 1292 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1292 Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu 1 5 10 <210> SEQ ID NO 1293 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1293 Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 <210> SEQ ID NO 1294 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1294 Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala 1 5 10 <210> SEQ ID NO 1295 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1295 Leu Asp Val Ser Ala Ala Phe Tyr 1 5 <210> SEQ ID NO 1296 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1296 Leu Asp Tyr Gln Gly Met Leu Pro Val 1 5 <210> SEQ ID NO 1297 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1297 Leu Glu Glu Glu Leu Pro Arg Leu 1 5 <210> SEQ ID NO 1298 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1298 Leu Glu Glu Glu Leu Pro Arg Leu Ala 1 5 <210> SEQ ID NO 1299 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1299 Met Asp Asp Val Val Leu Gly Ala 1 5 <210> SEQ ID NO 1300 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1300 Met Asp Asp Val Val Leu Gly Ala Lys Ser Val 1 5 10 <210> SEQ ID NO 1301 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1301 Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 1302 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1302 Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala 1 5 10 <210> SEQ ID NO 1303 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1303 Pro Asp His Gln Leu Asp Pro Ala 1 5 <210> SEQ ID NO 1304 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1304 Pro Asp His Gln Leu Asp Pro Ala Phe 1 5 <210> SEQ ID NO 1305 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1305 Pro Glu His Cys Ser Pro His His Thr Ala 1 5 10 <210> SEQ ID NO 1306 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1306 Pro Glu His Cys Ser Pro His His Thr Ala Leu 1 5 10 <210> SEQ ID NO 1307 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1307 Arg Asp Leu Leu Asp Thr Ala Ser Ala 1 5 <210> SEQ ID NO 1308 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1308 Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu 1 5 10 <210> SEQ ID NO 1309 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1309 Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 1310 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1310 Arg Asp Val Leu Cys Leu Arg Pro Val 1 5 <210> SEQ ID NO 1311 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1311 Arg Asp Val Leu Cys Leu Arg Pro Val Gly Ala 1 5 10 <210> SEQ ID NO 1312 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1312 Arg Glu Thr Val Leu Glu Tyr Leu 1 5 <210> SEQ ID NO 1313 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1313 Arg Glu Thr Val Leu Glu Tyr Leu Val 1 5 <210> SEQ ID NO 1314 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1314 Thr Asp Asn Ser Val Val Leu Ser Arg Lys Tyr 1 5 10 <210> SEQ ID NO 1315 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1315 Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 10 <210> SEQ ID NO 1316 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1316 Trp Glu Glu Leu Gly Glu Glu Ile 1 5 <210> SEQ ID NO 1317 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1317 Trp Glu Glu Leu Gly Glu Glu Ile Arg Leu 1 5 10 <210> SEQ ID NO 1318 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1318 Ala Ala Met Pro His Leu Leu Val 1 5 <210> SEQ ID NO 1319 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1319 Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 <210> SEQ ID NO 1320 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1320 Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 <210> SEQ ID NO 1321 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1321 Ala Ser Phe Cys Gly Ser Pro Tyr 1 5 <210> SEQ ID NO 1322 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1322 Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp 1 5 10 <210> SEQ ID NO 1323 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1323 Ala Ser Lys Leu Cys Leu Gly Trp 1 5 <210> SEQ ID NO 1324 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1324 Ala Ser Lys Leu Cys Leu Gly Trp Leu 1 5 <210> SEQ ID NO 1325 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1325 Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp 1 5 10 <210> SEQ ID NO 1326 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1326 Ala Ser Pro Leu His Val Ala Trp 1 5 <210> SEQ ID NO 1327 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1327 Ala Ser Val Arg Phe Ser Trp Leu 1 5 <210> SEQ ID NO 1328 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1328 Ala Ser Val Arg Phe Ser Trp Leu Ser Leu 1 5 10 <210> SEQ ID NO 1329 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1329 Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 1 5 10 <210> SEQ ID NO 1330 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1330 Ala Thr Pro Thr Gly Trp Gly Leu 1 5 <210> SEQ ID NO 1331 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1331 Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 10 <210> SEQ ID NO 1332 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1332 Cys Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 10 <210> SEQ ID NO 1333 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1333 Cys Ser Pro His His Thr Ala Leu 1 5 <210> SEQ ID NO 1334 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1334 Cys Ser Arg Asn Leu Tyr Val Ser Leu 1 5 <210> SEQ ID NO 1335 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1335 Cys Ser Val Val Arg Arg Ala Phe 1 5 <210> SEQ ID NO 1336 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1336 Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp 1 5 10 <210> SEQ ID NO 1337 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1337 Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 <210> SEQ ID NO 1338 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1338 Asp Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 10 <210> SEQ ID NO 1339 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1339 Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 1340 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1340 Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu 1 5 10 <210> SEQ ID NO 1341 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1341 Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala 1 5 10 <210> SEQ ID NO 1342 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1342 Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 <210> SEQ ID NO 1343 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1343 Glu Ala Gly Pro Leu Glu Glu Glu Leu 1 5 <210> SEQ ID NO 1344 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1344 Glu Ser Arg Leu Val Val Asp Phe 1 5 <210> SEQ ID NO 1345 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1345 Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 10 <210> SEQ ID NO 1346 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1346 Glu Thr Val Leu Glu Tyr Leu Val 1 5 <210> SEQ ID NO 1347 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1347 Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 10 <210> SEQ ID NO 1348 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1348 Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 <210> SEQ ID NO 1349 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1349 Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 <210> SEQ ID NO 1350 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1350 Phe Ala Ser Pro Leu His Val Ala Trp 1 5 <210> SEQ ID NO 1351 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1351 Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 <210> SEQ ID NO 1352 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1352 Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 <210> SEQ ID NO 1353 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1353 Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 <210> SEQ ID NO 1354 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1354 Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 <210> SEQ ID NO 1355 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1355 Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 10 <210> SEQ ID NO 1356 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1356 Phe Ser Trp Leu Ser Leu Leu Val 1 5 <210> SEQ ID NO 1357 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1357 Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 10 <210> SEQ ID NO 1358 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1358 Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val 1 5 10 <210> SEQ ID NO 1359 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1359 Phe Ser Tyr Met Asp Asp Val Val 1 5 <210> SEQ ID NO 1360 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1360 Phe Ser Tyr Met Asp Asp Val Val Leu 1 5 <210> SEQ ID NO 1361 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1361 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 10 <210> SEQ ID NO 1362 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1362 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 10 <210> SEQ ID NO 1363 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1363 Phe Thr Gly Leu Tyr Ser Ser Thr Val 1 5 <210> SEQ ID NO 1364 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1364 Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 <210> SEQ ID NO 1365 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1365 Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met 1 5 10 <210> SEQ ID NO 1366 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1366 Phe Thr Ser Ala Ile Cys Ser Val 1 5 <210> SEQ ID NO 1367 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1367 Phe Thr Ser Ala Ile Cys Ser Val Val 1 5 <210> SEQ ID NO 1368 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1368 Gly Ala His Leu Ser Leu Arg Gly Leu 1 5 <210> SEQ ID NO 1369 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1369 Gly Ala His Leu Ser Leu Arg Gly Leu Pro Val 1 5 10 <210> SEQ ID NO 1370 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1370 Gly Ala Lys Ser Val Gln His Leu 1 5 <210> SEQ ID NO 1371 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1371 Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu 1 5 10 <210> SEQ ID NO 1372 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1372 Gly Ser Ser Ser Gly Thr Val Asn Pro Val 1 5 10 <210> SEQ ID NO 1373 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1373 Gly Thr Asp Asn Ser Val Val Leu 1 5 <210> SEQ ID NO 1374 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1374 Gly Thr Asn Leu Ser Val Pro Asn Pro Leu 1 5 10 <210> SEQ ID NO 1375 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1375 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 10 <210> SEQ ID NO 1376 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1376 His Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 10 <210> SEQ ID NO 1377 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1377 His Thr Ala Leu Arg Gln Ala Ile 1 5 <210> SEQ ID NO 1378 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1378 His Thr Ala Leu Arg Gln Ala Ile Leu 1 5 <210> SEQ ID NO 1379 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1379 His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 10 <210> SEQ ID NO 1380 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1380 His Thr Leu Trp Lys Ala Gly Ile 1 5 <210> SEQ ID NO 1381 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1381 His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 <210> SEQ ID NO 1382 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1382 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 1383 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1383 Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val 1 5 10 <210> SEQ ID NO 1384 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1384 Lys Ser Val Gln His Leu Glu Ser Leu 1 5 <210> SEQ ID NO 1385 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1385 Lys Thr Lys Arg Trp Gly Tyr Ser Leu 1 5 <210> SEQ ID NO 1386 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1386 Lys Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 1387 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1387 Leu Ala Phe Ser Tyr Met Asp Asp Val 1 5 <210> SEQ ID NO 1388 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1388 Leu Ala Phe Ser Tyr Met Asp Asp Val Val 1 5 10 <210> SEQ ID NO 1389 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1389 Leu Ala Phe Ser Tyr Met Asp Asp Val Val Leu 1 5 10 <210> SEQ ID NO 1390 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1390 Leu Ala Gln Phe Thr Ser Ala Ile 1 5 <210> SEQ ID NO 1391 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1391 Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val 1 5 10 <210> SEQ ID NO 1392 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1392 Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 1393 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1393 Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 <210> SEQ ID NO 1394 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1394 Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 1395 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1395 Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 1396 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1396 Leu Ser Leu Leu Val Pro Phe Val 1 5 <210> SEQ ID NO 1397 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1397 Leu Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 10 <210> SEQ ID NO 1398 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1398 Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 1399 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1399 Leu Ser Leu Arg Gly Leu Pro Val 1 5 <210> SEQ ID NO 1400 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1400 Leu Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 1401 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1401 Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 <210> SEQ ID NO 1402 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1402 Leu Ser Pro Thr Val Trp Leu Ser Val 1 5 <210> SEQ ID NO 1403 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1403 Leu Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 10 <210> SEQ ID NO 1404 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1404 Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 10 <210> SEQ ID NO 1405 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1405 Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 1406 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1406 Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 10 <210> SEQ ID NO 1407 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1407 Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu 1 5 10 <210> SEQ ID NO 1408 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1408 Leu Ser Ser Asn Leu Ser Trp Leu 1 5 <210> SEQ ID NO 1409 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1409 Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu 1 5 10 <210> SEQ ID NO 1410 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1410 Leu Ser Thr Leu Pro Glu Thr Thr Val 1 5 <210> SEQ ID NO 1411 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1411 Leu Ser Thr Leu Pro Glu Thr Thr Val Val 1 5 10 <210> SEQ ID NO 1412 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1412 Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 1413 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1413 Leu Ser Trp Leu Ser Leu Asp Val 1 5 <210> SEQ ID NO 1414 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1414 Leu Ser Tyr Gln His Phe Arg Lys Leu 1 5 <210> SEQ ID NO 1415 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1415 Leu Ser Tyr Gln His Phe Arg Lys Leu Leu 1 5 10 <210> SEQ ID NO 1416 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1416 Leu Ser Tyr Gln His Phe Arg Lys Leu Leu Leu 1 5 10 <210> SEQ ID NO 1417 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1417 Leu Thr Phe Gly Arg Glu Thr Val 1 5 <210> SEQ ID NO 1418 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1418 Leu Thr Phe Gly Arg Glu Thr Val Leu 1 5 <210> SEQ ID NO 1419 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1419 Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 10 <210> SEQ ID NO 1420 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1420 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 1421 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1421 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 1422 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1422 Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 <210> SEQ ID NO 1423 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1423 Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 10 <210> SEQ ID NO 1424 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1424 Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 <210> SEQ ID NO 1425 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1425 Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 1426 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1426 Met Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 1427 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1427 Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 10 <210> SEQ ID NO 1428 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1428 Asn Ala Pro Ile Leu Ser Thr Leu 1 5 <210> SEQ ID NO 1429 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1429 Asn Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 1430 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1430 Pro Ala Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 1431 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1431 Pro Ala Ala Met Pro His Leu Leu Val 1 5 <210> SEQ ID NO 1432 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1432 Pro Ala Asp Asp Pro Ser Arg Gly Arg Leu 1 5 10 <210> SEQ ID NO 1433 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1433 Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 1 5 10 <210> SEQ ID NO 1434 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1434 Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 10 <210> SEQ ID NO 1435 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1435 Pro Ala Arg Asp Val Leu Cys Leu 1 5 <210> SEQ ID NO 1436 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1436 Pro Ala Arg Asp Val Leu Cys Leu Arg Pro Val 1 5 10 <210> SEQ ID NO 1437 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1437 Pro Ala Arg Val Thr Gly Gly Val 1 5 <210> SEQ ID NO 1438 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1438 Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 <210> SEQ ID NO 1439 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1439 Pro Ala Arg Val Thr Gly Gly Val Phe Leu 1 5 10 <210> SEQ ID NO 1440 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1440 Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val 1 5 10 <210> SEQ ID NO 1441 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1441 Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 10 <210> SEQ ID NO 1442 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1442 Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 1 5 10 <210> SEQ ID NO 1443 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1443 Pro Ser Arg Gly Arg Leu Gly Leu 1 5 <210> SEQ ID NO 1444 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1444 Pro Thr Gly Trp Gly Leu Ala Ile 1 5 <210> SEQ ID NO 1445 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1445 Pro Thr Thr Gly Arg Thr Ser Leu 1 5 <210> SEQ ID NO 1446 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1446 Pro Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 1447 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1447 Pro Thr Val Gln Ala Ser Lys Leu 1 5 <210> SEQ ID NO 1448 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1448 Pro Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 10 <210> SEQ ID NO 1449 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1449 Pro Thr Val Trp Leu Ser Val Ile 1 5 <210> SEQ ID NO 1450 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1450 Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 1451 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1451 Pro Thr Val Trp Leu Ser Val Ile Trp Met 1 5 10 <210> SEQ ID NO 1452 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1452 Gln Ala Phe Thr Phe Ser Pro Thr Tyr 1 5 <210> SEQ ID NO 1453 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1453 Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu 1 5 10 <210> SEQ ID NO 1454 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1454 Gln Ala Ile Leu Cys Trp Gly Glu Leu 1 5 <210> SEQ ID NO 1455 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1455 Gln Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 10 <210> SEQ ID NO 1456 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1456 Gln Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 10 <210> SEQ ID NO 1457 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1457 Gln Ala Ser Lys Leu Cys Leu Gly Trp 1 5 <210> SEQ ID NO 1458 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1458 Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu 1 5 10 <210> SEQ ID NO 1459 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1459 Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp 1 5 10 <210> SEQ ID NO 1460 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1460 Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu 1 5 10 <210> SEQ ID NO 1461 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1461 Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 10 <210> SEQ ID NO 1462 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1462 Arg Ala Phe Pro His Cys Leu Ala Phe 1 5 <210> SEQ ID NO 1463 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1463 Arg Ala Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 10 <210> SEQ ID NO 1464 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1464 Arg Thr Pro Ala Arg Val Thr Gly Gly Val 1 5 10 <210> SEQ ID NO 1465 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1465 Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 1466 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1466 Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 <210> SEQ ID NO 1467 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1467 Ser Ala Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 10 <210> SEQ ID NO 1468 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1468 Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 <210> SEQ ID NO 1469 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1469 Ser Ala Ser Phe Cys Gly Ser Pro Tyr 1 5 <210> SEQ ID NO 1470 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1470 Ser Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp 1 5 10 <210> SEQ ID NO 1471 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1471 Ser Ser Ala Gly Pro Cys Ala Leu 1 5 <210> SEQ ID NO 1472 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1472 Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 10 <210> SEQ ID NO 1473 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1473 Ser Ser Gly Thr Val Asn Pro Val 1 5 <210> SEQ ID NO 1474 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1474 Ser Ser Asn Leu Ser Trp Leu Ser Leu 1 5 <210> SEQ ID NO 1475 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1475 Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp Val 1 5 10 <210> SEQ ID NO 1476 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1476 Ser Ser Ser Gly Thr Val Asn Pro Val 1 5 <210> SEQ ID NO 1477 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1477 Ser Thr Leu Pro Glu Thr Thr Val 1 5 <210> SEQ ID NO 1478 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1478 Ser Thr Leu Pro Glu Thr Thr Val Val 1 5 <210> SEQ ID NO 1479 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1479 Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 1480 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1480 Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 1481 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1481 Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 <210> SEQ ID NO 1482 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1482 Thr Ala Leu Arg Gln Ala Ile Leu 1 5 <210> SEQ ID NO 1483 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1483 Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 10 <210> SEQ ID NO 1484 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1484 Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 <210> SEQ ID NO 1485 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1485 Thr Ser Ala Ile Cys Ser Val Val 1 5 <210> SEQ ID NO 1486 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1486 Thr Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 10 <210> SEQ ID NO 1487 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1487 Thr Ser Gly Phe Leu Gly Pro Leu 1 5 <210> SEQ ID NO 1488 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1488 Thr Ser Gly Phe Leu Gly Pro Leu Leu 1 5 <210> SEQ ID NO 1489 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1489 Thr Ser Gly Phe Leu Gly Pro Leu Leu Val 1 5 10 <210> SEQ ID NO 1490 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1490 Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu 1 5 10 <210> SEQ ID NO 1491 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1491 Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 1492 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1492 Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 1493 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1493 Val Ala Glu Asp Leu Asn Leu Gly Asn Leu 1 5 10 <210> SEQ ID NO 1494 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1494 Val Ser Ile Pro Trp Thr His Lys Val 1 5 <210> SEQ ID NO 1495 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1495 Val Ser Trp Pro Lys Phe Ala Val 1 5 <210> SEQ ID NO 1496 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1496 Val Ser Trp Pro Lys Phe Ala Val Pro Asn Leu 1 5 10 <210> SEQ ID NO 1497 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1497 Val Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 1498 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1498 Trp Ser Pro Gln Ala Gln Gly Ile 1 5 <210> SEQ ID NO 1499 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1499 Trp Ser Pro Gln Ala Gln Gly Ile Leu 1 5 <210> SEQ ID NO 1500 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1500 Trp Thr His Lys Val Gly Asn Phe 1 5 <210> SEQ ID NO 1501 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1501 Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu 1 5 10 <210> SEQ ID NO 1502 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1502 Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 <210> SEQ ID NO 1503 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1503 Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 <210> SEQ ID NO 1504 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1504 Tyr Ser Leu Asn Phe Met Gly Tyr Val 1 5 <210> SEQ ID NO 1505 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1505 Tyr Ser Leu Asn Phe Met Gly Tyr Val Ile 1 5 10 <210> SEQ ID NO 1506 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1506 Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 1507 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1507 Ala Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 10 <210> SEQ ID NO 1508 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1508 Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 1509 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1509 Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 1510 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1510 Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 <210> SEQ ID NO 1511 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1511 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 1512 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1512 Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 <210> SEQ ID NO 1513 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1513 Ala Gln Phe Thr Ser Ala Ile Cys Ser Val 1 5 10 <210> SEQ ID NO 1514 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1514 Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val 1 5 10 <210> SEQ ID NO 1515 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1515 Cys Ile Pro Ile Pro Ser Ser Trp 1 5 <210> SEQ ID NO 1516 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1516 Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 10 <210> SEQ ID NO 1517 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1517 Cys Leu Ala Phe Ser Tyr Met Asp Asp Val 1 5 10 <210> SEQ ID NO 1518 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1518 Cys Leu Ala Phe Ser Tyr Met Asp Asp Val Val 1 5 10 <210> SEQ ID NO 1519 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1519 Cys Leu Gly Trp Leu Trp Gly Met 1 5 <210> SEQ ID NO 1520 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1520 Cys Leu Gly Trp Leu Trp Gly Met Asp Ile 1 5 10 <210> SEQ ID NO 1521 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1521 Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 1522 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1522 Cys Leu Arg Arg Phe Ile Ile Phe 1 5 <210> SEQ ID NO 1523 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1523 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 1 5 10 <210> SEQ ID NO 1524 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1524 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile 1 5 10 <210> SEQ ID NO 1525 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1525 Cys Leu Thr Phe Gly Arg Glu Thr Val 1 5 <210> SEQ ID NO 1526 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1526 Cys Gln Leu Asp Pro Ala Arg Asp Val 1 5 <210> SEQ ID NO 1527 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1527 Cys Gln Arg Ile Val Gly Leu Leu Gly Phe 1 5 10 <210> SEQ ID NO 1528 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1528 Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 1529 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1529 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 1530 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1530 Asp Leu Asn Leu Gly Asn Leu Asn Val 1 5 <210> SEQ ID NO 1531 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1531 Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 10 <210> SEQ ID NO 1532 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1532 Asp Pro Arg Val Arg Gly Leu Tyr 1 5 <210> SEQ ID NO 1533 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1533 Asp Val Leu Cys Leu Arg Pro Val 1 5 <210> SEQ ID NO 1534 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1534 Asp Val Val Leu Gly Ala Lys Ser Val 1 5 <210> SEQ ID NO 1535 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1535 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 10 <210> SEQ ID NO 1536 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1536 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 1537 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1537 Phe Ile Leu Leu Leu Cys Leu Ile 1 5 <210> SEQ ID NO 1538 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1538 Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 1539 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1539 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 10 <210> SEQ ID NO 1540 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1540 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 1541 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1541 Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 10 <210> SEQ ID NO 1542 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1542 Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 1543 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1543 Phe Leu Leu Val Leu Leu Asp Tyr 1 5 <210> SEQ ID NO 1544 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1544 Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 1545 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1545 Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 1 5 10 <210> SEQ ID NO 1546 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1546 Phe Pro Asp His Gln Leu Asp Pro Ala Phe 1 5 10 <210> SEQ ID NO 1547 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1547 Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 1548 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1548 Phe Pro His Cys Leu Ala Phe Ser Tyr Met 1 5 10 <210> SEQ ID NO 1549 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1549 Phe Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 10 <210> SEQ ID NO 1550 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1550 Phe Val Gly Leu Ser Pro Thr Val 1 5 <210> SEQ ID NO 1551 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1551 Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 <210> SEQ ID NO 1552 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1552 Phe Val Leu Gly Gly Cys Arg His Lys Leu Val 1 5 10 <210> SEQ ID NO 1553 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1553 Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 1554 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1554 Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 10 <210> SEQ ID NO 1555 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1555 Gly Leu Ser Pro Thr Val Trp Leu Ser Val 1 5 10 <210> SEQ ID NO 1556 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1556 Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 10 <210> SEQ ID NO 1557 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1557 Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 <210> SEQ ID NO 1558 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1558 Gly Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 10 <210> SEQ ID NO 1559 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1559 Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 1560 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1560 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 10 <210> SEQ ID NO 1561 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1561 His Leu Asn Pro Asn Lys Thr Lys Arg Trp 1 5 10 <210> SEQ ID NO 1562 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1562 His Leu Ser Leu Arg Gly Leu Pro Val 1 5 <210> SEQ ID NO 1563 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1563 His Leu Tyr Ser His Pro Ile Ile 1 5 <210> SEQ ID NO 1564 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1564 His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 1565 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1565 His Pro Ala Ala Met Pro His Leu Leu Val 1 5 10 <210> SEQ ID NO 1566 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1566 His Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 10 <210> SEQ ID NO 1567 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1567 Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 1568 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1568 Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 1569 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1569 Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 1570 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1570 Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 <210> SEQ ID NO 1571 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1571 Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 1572 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1572 Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 10 <210> SEQ ID NO 1573 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1573 Ile Leu Arg Gly Thr Ser Phe Val 1 5 <210> SEQ ID NO 1574 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1574 Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 <210> SEQ ID NO 1575 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1575 Ile Leu Arg Gly Thr Ser Phe Val Tyr Val 1 5 10 <210> SEQ ID NO 1576 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1576 Ile Leu Ser Thr Leu Pro Glu Thr Thr Val 1 5 10 <210> SEQ ID NO 1577 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1577 Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val 1 5 10 <210> SEQ ID NO 1578 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1578 Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 1579 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1579 Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 1580 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1580 Ile Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 10 <210> SEQ ID NO 1581 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1581 Ile Pro Gln Ser Leu Asp Ser Trp 1 5 <210> SEQ ID NO 1582 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1582 Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 <210> SEQ ID NO 1583 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1583 Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 <210> SEQ ID NO 1584 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1584 Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 10 <210> SEQ ID NO 1585 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1585 Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 10 <210> SEQ ID NO 1586 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1586 Lys Leu Cys Leu Gly Trp Leu Trp 1 5 <210> SEQ ID NO 1587 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1587 Lys Leu Cys Leu Gly Trp Leu Trp Gly Met 1 5 10 <210> SEQ ID NO 1588 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1588 Lys Leu His Leu Tyr Ser His Pro Ile 1 5 <210> SEQ ID NO 1589 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1589 Lys Leu His Leu Tyr Ser His Pro Ile Ile 1 5 10 <210> SEQ ID NO 1590 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1590 Lys Leu Ile Met Pro Ala Arg Phe 1 5 <210> SEQ ID NO 1591 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1591 Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 1592 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1592 Lys Leu Pro Val Asn Arg Pro Ile 1 5 <210> SEQ ID NO 1593 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1593 Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 <210> SEQ ID NO 1594 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1594 Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr 1 5 10 <210> SEQ ID NO 1595 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1595 Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 <210> SEQ ID NO 1596 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1596 Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 1597 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1597 Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 1598 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1598 Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 <210> SEQ ID NO 1599 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1599 Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 <210> SEQ ID NO 1600 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1600 Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 <210> SEQ ID NO 1601 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1601 Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 1602 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1602 Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 1603 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1603 Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 <210> SEQ ID NO 1604 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1604 Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 1605 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1605 Leu Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile 1 5 10 <210> SEQ ID NO 1606 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1606 Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 10 <210> SEQ ID NO 1607 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1607 Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 <210> SEQ ID NO 1608 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1608 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 10 <210> SEQ ID NO 1609 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1609 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 10 <210> SEQ ID NO 1610 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1610 Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 1611 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1611 Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 1612 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1612 Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 1613 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1613 Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 1614 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1614 Leu Leu Val Gly Ser Ser Gly Leu 1 5 <210> SEQ ID NO 1615 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1615 Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 1616 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1616 Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 1617 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1617 Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 1618 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1618 Leu Leu Val Pro Phe Val Gln Trp 1 5 <210> SEQ ID NO 1619 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1619 Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 1620 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1620 Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 <210> SEQ ID NO 1621 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1621 Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 10 <210> SEQ ID NO 1622 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1622 Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 1623 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1623 Leu Pro Ile Phe Phe Cys Leu Trp 1 5 <210> SEQ ID NO 1624 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1624 Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 <210> SEQ ID NO 1625 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1625 Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 10 <210> SEQ ID NO 1626 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1626 Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 10 <210> SEQ ID NO 1627 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1627 Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 10 <210> SEQ ID NO 1628 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1628 Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 1629 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1629 Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 <210> SEQ ID NO 1630 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1630 Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val 1 5 10 <210> SEQ ID NO 1631 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1631 Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile 1 5 10 <210> SEQ ID NO 1632 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1632 Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 1633 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1633 Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 1634 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1634 Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 1635 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1635 Leu Val Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 1636 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1636 Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 1637 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1637 Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 1638 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1638 Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 1639 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1639 Met Pro Leu Ser Tyr Gln His Phe 1 5 <210> SEQ ID NO 1640 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1640 Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 1641 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1641 Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 <210> SEQ ID NO 1642 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1642 Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp 1 5 10 <210> SEQ ID NO 1643 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1643 Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 1644 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1644 Asn Leu Asn Val Ser Ile Pro Trp 1 5 <210> SEQ ID NO 1645 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1645 Asn Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 10 <210> SEQ ID NO 1646 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1646 Asn Leu Ser Trp Leu Ser Leu Asp Val 1 5 <210> SEQ ID NO 1647 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1647 Asn Pro Asn Lys Thr Lys Arg Trp 1 5 <210> SEQ ID NO 1648 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1648 Asn Pro Asn Lys Thr Lys Arg Trp Gly Tyr 1 5 10 <210> SEQ ID NO 1649 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1649 Asn Val Ser Ile Pro Trp Thr His Lys Val 1 5 10 <210> SEQ ID NO 1650 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1650 Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 10 <210> SEQ ID NO 1651 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1651 Pro Ile Asp Trp Lys Val Cys Gln Arg Ile Val 1 5 10 <210> SEQ ID NO 1652 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1652 Pro Ile Phe Phe Cys Leu Trp Val 1 5 <210> SEQ ID NO 1653 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1653 Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 <210> SEQ ID NO 1654 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1654 Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 10 <210> SEQ ID NO 1655 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1655 Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 1656 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1656 Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 1657 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1657 Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val 1 5 10 <210> SEQ ID NO 1658 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1658 Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 1659 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1659 Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 <210> SEQ ID NO 1660 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1660 Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 1661 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1661 Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 10 <210> SEQ ID NO 1662 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1662 Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 10 <210> SEQ ID NO 1663 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1663 Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 1664 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1664 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 1665 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1665 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 1666 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1666 Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 10 <210> SEQ ID NO 1667 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1667 Pro Pro His Gly Gly Leu Leu Gly Trp 1 5 <210> SEQ ID NO 1668 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1668 Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 10 <210> SEQ ID NO 1669 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1669 Pro Gln Ser Leu Asp Ser Trp Trp 1 5 <210> SEQ ID NO 1670 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1670 Pro Val Asn Arg Pro Ile Asp Trp 1 5 <210> SEQ ID NO 1671 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1671 Pro Val Asn Arg Pro Ile Asp Trp Lys Val 1 5 10 <210> SEQ ID NO 1672 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1672 Gln Leu Asp Pro Ala Arg Asp Val 1 5 <210> SEQ ID NO 1673 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1673 Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 10 <210> SEQ ID NO 1674 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1674 Arg Ile Val Gly Leu Leu Gly Phe 1 5 <210> SEQ ID NO 1675 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1675 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 10 <210> SEQ ID NO 1676 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1676 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 10 <210> SEQ ID NO 1677 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1677 Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 1678 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1678 Arg Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 10 <210> SEQ ID NO 1679 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1679 Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 10 <210> SEQ ID NO 1680 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1680 Arg Gln Leu Leu Trp Phe His Ile 1 5 <210> SEQ ID NO 1681 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1681 Arg Val His Phe Ala Ser Pro Leu His Val 1 5 10 <210> SEQ ID NO 1682 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1682 Arg Val Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 1683 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1683 Ser Ile Pro Trp Thr His Lys Val 1 5 <210> SEQ ID NO 1684 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1684 Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 <210> SEQ ID NO 1685 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1685 Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 1686 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1686 Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 1687 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1687 Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 <210> SEQ ID NO 1688 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1688 Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 <210> SEQ ID NO 1689 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1689 Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 1690 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1690 Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 <210> SEQ ID NO 1691 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1691 Ser Leu Asn Phe Met Gly Tyr Val 1 5 <210> SEQ ID NO 1692 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1692 Ser Leu Asn Phe Met Gly Tyr Val Ile 1 5 <210> SEQ ID NO 1693 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1693 Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 1694 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1694 Ser Pro Phe Leu Leu Ala Gln Phe 1 5 <210> SEQ ID NO 1695 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1695 Ser Pro His His Thr Ala Leu Arg Gln Ala Ile 1 5 10 <210> SEQ ID NO 1696 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1696 Ser Pro Thr Val Trp Leu Ser Val 1 5 <210> SEQ ID NO 1697 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1697 Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 <210> SEQ ID NO 1698 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1698 Ser Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 10 <210> SEQ ID NO 1699 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1699 Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met 1 5 10 <210> SEQ ID NO 1700 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1700 Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 1701 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1701 Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val 1 5 10 <210> SEQ ID NO 1702 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1702 Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 1703 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1703 Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 1704 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1704 Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 <210> SEQ ID NO 1705 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1705 Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 1706 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1706 Thr Leu Pro Glu Thr Thr Val Val 1 5 <210> SEQ ID NO 1707 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1707 Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 1708 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1708 Thr Pro Ala Arg Val Thr Gly Gly Val 1 5 <210> SEQ ID NO 1709 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1709 Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 1710 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1710 Thr Pro Pro His Gly Gly Leu Leu Gly Trp 1 5 10 <210> SEQ ID NO 1711 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1711 Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 <210> SEQ ID NO 1712 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1712 Thr Gln Cys Gly Tyr Pro Ala Leu Met 1 5 <210> SEQ ID NO 1713 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1713 Thr Val Gln Ala Ser Lys Leu Cys Leu Gly Trp 1 5 10 <210> SEQ ID NO 1714 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1714 Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 1715 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1715 Thr Val Trp Leu Ser Val Ile Trp Met 1 5 <210> SEQ ID NO 1716 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1716 Val Leu Gly Gly Cys Arg His Lys Leu Val 1 5 10 <210> SEQ ID NO 1717 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1717 Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 1718 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1718 Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 1719 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1719 Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 1720 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1720 Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 10 <210> SEQ ID NO 1721 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1721 Val Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 1722 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1722 Val Gln Ala Ser Lys Leu Cys Leu Gly Trp 1 5 10 <210> SEQ ID NO 1723 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1723 Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val 1 5 10 <210> SEQ ID NO 1724 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1724 Val Val Leu Gly Ala Lys Ser Val 1 5 <210> SEQ ID NO 1725 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1725 Trp Ile Leu Arg Gly Thr Ser Phe 1 5 <210> SEQ ID NO 1726 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1726 Trp Ile Leu Arg Gly Thr Ser Phe Val 1 5 <210> SEQ ID NO 1727 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1727 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 10 <210> SEQ ID NO 1728 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1728 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val 1 5 10 <210> SEQ ID NO 1729 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1729 Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 <210> SEQ ID NO 1730 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1730 Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 1731 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1731 Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 10 <210> SEQ ID NO 1732 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1732 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 <210> SEQ ID NO 1733 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1733 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 1734 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1734 Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 1735 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1735 Trp Leu Ser Leu Leu Val Pro Phe Val 1 5 <210> SEQ ID NO 1736 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1736 Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 10 <210> SEQ ID NO 1737 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1737 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 10 <210> SEQ ID NO 1738 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1738 Trp Met Cys Leu Arg Arg Phe Ile 1 5 <210> SEQ ID NO 1739 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1739 Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 <210> SEQ ID NO 1740 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1740 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 1741 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1741 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 10 <210> SEQ ID NO 1742 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1742 Tyr Leu His Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 1743 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1743 Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 <210> SEQ ID NO 1744 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1744 Tyr Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 10 <210> SEQ ID NO 1745 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1745 Tyr Leu Val Ser Phe Gly Val Trp 1 5 <210> SEQ ID NO 1746 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1746 Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 1747 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1747 Tyr Pro Ala Leu Met Pro Leu Tyr 1 5 <210> SEQ ID NO 1748 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1748 Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 10 <210> SEQ ID NO 1749 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1749 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 1750 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1750 Asp Asn Ser Val Val Leu Ser Arg Lys Tyr 1 5 10 <210> SEQ ID NO 1751 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1751 Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 10 <210> SEQ ID NO 1752 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1752 Gly Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 <210> SEQ ID NO 1753 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1753 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 1754 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1754 Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr 1 5 10 <210> SEQ ID NO 1755 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1755 Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 <210> SEQ ID NO 1756 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1756 Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 1757 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1757 Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 1758 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1758 Met Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 1759 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1759 Asn Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 1760 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1760 Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 <210> SEQ ID NO 1761 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1761 Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 1762 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1762 Pro Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 1763 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1763 Ser Ala Ser Phe Cys Gly Ser Pro Tyr 1 5 <210> SEQ ID NO 1764 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1764 Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 <210> SEQ ID NO 1765 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1765 Ala Ala Cys Phe Ala Arg Ser Arg 1 5 <210> SEQ ID NO 1766 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1766 Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 <210> SEQ ID NO 1767 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1767 Ala Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 10 <210> SEQ ID NO 1768 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1768 Ala Phe Ser Ser Ala Gly Pro Cys Ala 1 5 <210> SEQ ID NO 1769 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1769 Ala Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 1770 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1770 Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala 1 5 10 <210> SEQ ID NO 1771 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1771 Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg 1 5 10 <210> SEQ ID NO 1772 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1772 Ala Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 1773 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1773 Ala Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 10 <210> SEQ ID NO 1774 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1774 Ala Leu Asn Pro Ala Asp Asp Pro Ser Arg 1 5 10 <210> SEQ ID NO 1775 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1775 Ala Leu Arg Phe Thr Ser Ala Arg 1 5 <210> SEQ ID NO 1776 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1776 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 1777 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1777 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 1778 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1778 Ala Met Gln Trp Asn Ser Thr Thr Phe His 1 5 10 <210> SEQ ID NO 1779 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1779 Ala Ser Pro Leu His Val Ala Trp Arg 1 5 <210> SEQ ID NO 1780 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1780 Ala Ser Thr Asn Arg Gln Ser Gly Arg 1 5 <210> SEQ ID NO 1781 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1781 Cys Ala Ala Asn Trp Ile Leu Arg 1 5 <210> SEQ ID NO 1782 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1782 Cys Ala Leu Arg Phe Thr Ser Ala Arg 1 5 <210> SEQ ID NO 1783 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1783 Cys Phe Ala Arg Ser Arg Ser Gly Ala 1 5 <210> SEQ ID NO 1784 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1784 Cys Phe Arg Lys Leu Pro Val Asn Arg 1 5 <210> SEQ ID NO 1785 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1785 Cys Gly Tyr Pro Ala Leu Met Pro Leu Tyr 1 5 10 <210> SEQ ID NO 1786 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1786 Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 10 <210> SEQ ID NO 1787 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1787 Cys Leu Arg Pro Val Gly Ala Glu Ser Arg 1 5 10 <210> SEQ ID NO 1788 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1788 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 1 5 10 <210> SEQ ID NO 1789 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1789 Cys Ser Pro His His Thr Ala Leu Arg 1 5 <210> SEQ ID NO 1790 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1790 Cys Ser Val Val Arg Arg Ala Phe Pro His 1 5 10 <210> SEQ ID NO 1791 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1791 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 1792 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1792 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 10 <210> SEQ ID NO 1793 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1793 Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 1794 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1794 Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 <210> SEQ ID NO 1795 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1795 Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg 1 5 10 <210> SEQ ID NO 1796 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1796 Glu Leu Leu Ala Ala Cys Phe Ala Arg 1 5 <210> SEQ ID NO 1797 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1797 Glu Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 10 <210> SEQ ID NO 1798 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1798 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 10 <210> SEQ ID NO 1799 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1799 Glu Ser Pro Glu His Cys Ser Pro His 1 5 <210> SEQ ID NO 1800 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1800 Glu Ser Pro Glu His Cys Ser Pro His His 1 5 10 <210> SEQ ID NO 1801 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1801 Glu Thr Thr Val Val Arg Arg Arg 1 5 <210> SEQ ID NO 1802 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1802 Glu Thr Thr Val Val Arg Arg Arg Gly Arg 1 5 10 <210> SEQ ID NO 1803 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1803 Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 10 <210> SEQ ID NO 1804 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1804 Phe Ala Ser Pro Leu His Val Ala Trp Arg 1 5 10 <210> SEQ ID NO 1805 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1805 Phe Phe Pro Asp His Gln Leu Asp Pro Ala 1 5 10 <210> SEQ ID NO 1806 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1806 Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 <210> SEQ ID NO 1807 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1807 Phe Gly Val Glu Pro Ser Gly Ser Gly His 1 5 10 <210> SEQ ID NO 1808 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1808 Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 1809 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1809 Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg 1 5 10 <210> SEQ ID NO 1810 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1810 Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 10 <210> SEQ ID NO 1811 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1811 Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 1812 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1812 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 10 <210> SEQ ID NO 1813 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1813 Phe Thr Ser Ala Ile Cys Ser Val Val Arg 1 5 10 <210> SEQ ID NO 1814 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1814 Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 10 <210> SEQ ID NO 1815 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1815 Phe Val Leu Gly Gly Cys Arg His Lys 1 5 <210> SEQ ID NO 1816 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1816 Gly Cys Ala Ala Asn Trp Ile Leu Arg 1 5 <210> SEQ ID NO 1817 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1817 Gly Ile His Leu Asn Pro Asn Lys 1 5 <210> SEQ ID NO 1818 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1818 Gly Ile His Leu Asn Pro Asn Lys Thr Lys 1 5 10 <210> SEQ ID NO 1819 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1819 Gly Ile His Leu Asn Pro Asn Lys Thr Lys Arg 1 5 10 <210> SEQ ID NO 1820 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1820 Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 1821 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1821 Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 10 <210> SEQ ID NO 1822 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1822 Gly Met Asp Ile Asp Pro Tyr Lys 1 5 <210> SEQ ID NO 1823 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1823 Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 <210> SEQ ID NO 1824 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1824 Gly Thr Asp Asn Ser Val Val Leu Ser Arg 1 5 10 <210> SEQ ID NO 1825 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1825 Gly Thr Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 <210> SEQ ID NO 1826 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1826 Gly Val Glu Pro Ser Gly Ser Gly His 1 5 <210> SEQ ID NO 1827 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1827 Gly Val Phe Leu Val Asp Lys Asn Pro His 1 5 10 <210> SEQ ID NO 1828 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1828 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 10 <210> SEQ ID NO 1829 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1829 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg 1 5 10 <210> SEQ ID NO 1830 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1830 His Cys Ser Pro His His Thr Ala Leu Arg 1 5 10 <210> SEQ ID NO 1831 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1831 His Phe Ala Ser Pro Leu His Val Ala 1 5 <210> SEQ ID NO 1832 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1832 His Ile Ser Cys Leu Thr Phe Gly Arg 1 5 <210> SEQ ID NO 1833 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1833 His Leu Asn Pro Asn Lys Thr Lys 1 5 <210> SEQ ID NO 1834 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1834 His Leu Asn Pro Asn Lys Thr Lys Arg 1 5 <210> SEQ ID NO 1835 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1835 His Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 10 <210> SEQ ID NO 1836 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1836 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 1837 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1837 Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 <210> SEQ ID NO 1838 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1838 Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 <210> SEQ ID NO 1839 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1839 Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 <210> SEQ ID NO 1840 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1840 Ile Ser Cys Leu Thr Phe Gly Arg 1 5 <210> SEQ ID NO 1841 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1841 Lys Ala Gly Ile Leu Tyr Lys Arg 1 5 <210> SEQ ID NO 1842 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1842 Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 1843 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1843 Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys 1 5 10 <210> SEQ ID NO 1844 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1844 Lys Val Phe Val Leu Gly Gly Cys Arg 1 5 <210> SEQ ID NO 1845 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1845 Lys Val Phe Val Leu Gly Gly Cys Arg His 1 5 10 <210> SEQ ID NO 1846 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1846 Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 <210> SEQ ID NO 1847 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1847 Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 <210> SEQ ID NO 1848 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1848 Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 <210> SEQ ID NO 1849 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1849 Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 1850 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1850 Leu Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 <210> SEQ ID NO 1851 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1851 Leu Asp Val Ser Ala Ala Phe Tyr His 1 5 <210> SEQ ID NO 1852 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1852 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 1853 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1853 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 1854 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1854 Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg 1 5 10 <210> SEQ ID NO 1855 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1855 Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 <210> SEQ ID NO 1856 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1856 Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 1857 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1857 Leu Leu Ala Ala Cys Phe Ala Arg 1 5 <210> SEQ ID NO 1858 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1858 Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 10 <210> SEQ ID NO 1859 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1859 Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 10 <210> SEQ ID NO 1860 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1860 Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg 1 5 10 <210> SEQ ID NO 1861 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1861 Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 1862 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1862 Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 1863 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1863 Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 1864 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1864 Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 1865 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1865 Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 <210> SEQ ID NO 1866 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1866 Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 1867 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1867 Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 10 <210> SEQ ID NO 1868 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1868 Leu Ser Leu Arg Gly Leu Pro Val Cys Ala 1 5 10 <210> SEQ ID NO 1869 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1869 Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 <210> SEQ ID NO 1870 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1870 Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 1871 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1871 Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 1872 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1872 Leu Ser Trp Leu Ser Leu Asp Val Ser Ala 1 5 10 <210> SEQ ID NO 1873 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1873 Leu Ser Tyr Gln His Phe Arg Lys 1 5 <210> SEQ ID NO 1874 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1874 Leu Thr Val Asn Glu Lys Arg Arg 1 5 <210> SEQ ID NO 1875 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1875 Leu Val Ser Phe Gly Val Trp Ile Arg 1 5 <210> SEQ ID NO 1876 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1876 Leu Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 10 <210> SEQ ID NO 1877 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1877 Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 <210> SEQ ID NO 1878 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1878 Met Asp Asp Val Val Leu Gly Ala Lys 1 5 <210> SEQ ID NO 1879 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1879 Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 1880 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1880 Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 1881 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1881 Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 10 <210> SEQ ID NO 1882 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1882 Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 10 <210> SEQ ID NO 1883 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1883 Asn Phe Leu Leu Ser Leu Gly Ile His 1 5 <210> SEQ ID NO 1884 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1884 Asn Leu Glu Asp Pro Ala Ser Arg 1 5 <210> SEQ ID NO 1885 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1885 Asn Leu Asn Val Ser Ile Pro Trp Thr His 1 5 10 <210> SEQ ID NO 1886 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1886 Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys 1 5 10 <210> SEQ ID NO 1887 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1887 Asn Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 10 <210> SEQ ID NO 1888 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1888 Asn Ser Gln Ser Pro Thr Ser Asn His 1 5 <210> SEQ ID NO 1889 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1889 Asn Ser Val Val Leu Ser Arg Lys 1 5 <210> SEQ ID NO 1890 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1890 Asn Val Ser Ile Pro Trp Thr His Lys 1 5 <210> SEQ ID NO 1891 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1891 Pro Ala Asp Asp Pro Ser Arg Gly Arg 1 5 <210> SEQ ID NO 1892 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1892 Pro Ala Arg Asp Val Leu Cys Leu Arg 1 5 <210> SEQ ID NO 1893 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1893 Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 <210> SEQ ID NO 1894 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1894 Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 1 5 10 <210> SEQ ID NO 1895 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1895 Pro Cys Ala Leu Arg Phe Thr Ser Ala Arg 1 5 10 <210> SEQ ID NO 1896 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1896 Pro Asp His Gln Leu Asp Pro Ala Phe 1 5 <210> SEQ ID NO 1897 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1897 Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 1898 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1898 Pro Phe Thr Gln Cys Gly Tyr Pro Ala 1 5 <210> SEQ ID NO 1899 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1899 Pro Gly Tyr Arg Trp Met Cys Leu Arg 1 5 <210> SEQ ID NO 1900 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1900 Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg 1 5 10 <210> SEQ ID NO 1901 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1901 Pro Ile Asp Trp Lys Val Cys Gln Arg 1 5 <210> SEQ ID NO 1902 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1902 Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 <210> SEQ ID NO 1903 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1903 Pro Ile Ile Leu Gly Phe Arg Lys 1 5 <210> SEQ ID NO 1904 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1904 Pro Leu Glu Glu Glu Leu Pro Arg 1 5 <210> SEQ ID NO 1905 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1905 Pro Leu His Pro Ala Ala Met Pro His 1 5 <210> SEQ ID NO 1906 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1906 Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 1907 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1907 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 1908 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1908 Pro Leu Ser Tyr Gln His Phe Arg 1 5 <210> SEQ ID NO 1909 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1909 Pro Leu Ser Tyr Gln His Phe Arg Lys 1 5 <210> SEQ ID NO 1910 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1910 Pro Leu Thr Val Asn Glu Lys Arg 1 5 <210> SEQ ID NO 1911 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1911 Pro Leu Thr Val Asn Glu Lys Arg Arg 1 5 <210> SEQ ID NO 1912 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1912 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 1913 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1913 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 1914 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1914 Pro Val Gly Ala Glu Ser Arg Gly Arg 1 5 <210> SEQ ID NO 1915 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1915 Pro Val Asn Arg Pro Ile Asp Trp Lys 1 5 <210> SEQ ID NO 1916 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1916 Gln Ala Phe Thr Phe Ser Pro Thr Tyr 1 5 <210> SEQ ID NO 1917 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1917 Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 10 <210> SEQ ID NO 1918 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1918 Gln Ala Gly Phe Phe Leu Leu Thr Arg 1 5 <210> SEQ ID NO 1919 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1919 Gln Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 10 <210> SEQ ID NO 1920 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1920 Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg 1 5 10 <210> SEQ ID NO 1921 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1921 Gln Ser Ser Gly Ile Leu Ser Arg 1 5 <210> SEQ ID NO 1922 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1922 Arg Ala Phe Pro His Cys Leu Ala Phe 1 5 <210> SEQ ID NO 1923 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1923 Arg Leu Lys Leu Ile Met Pro Ala Arg 1 5 <210> SEQ ID NO 1924 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1924 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 10 <210> SEQ ID NO 1925 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1925 Arg Leu Lys Val Phe Val Leu Gly Gly Cys Arg 1 5 10 <210> SEQ ID NO 1926 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1926 Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 1927 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1927 Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 10 <210> SEQ ID NO 1928 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1928 Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro Arg 1 5 10 <210> SEQ ID NO 1929 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1929 Arg Ser Gln Ser Pro Arg Arg Arg 1 5 <210> SEQ ID NO 1930 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1930 Arg Ser Gln Ser Pro Arg Arg Arg Arg 1 5 <210> SEQ ID NO 1931 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1931 Arg Thr Pro Ser Pro Arg Arg Arg 1 5 <210> SEQ ID NO 1932 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1932 Arg Thr Pro Ser Pro Arg Arg Arg Arg 1 5 <210> SEQ ID NO 1933 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1933 Arg Val His Phe Ala Ser Pro Leu His 1 5 <210> SEQ ID NO 1934 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1934 Arg Val Thr Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 1935 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1935 Ser Ala Gly Pro Cys Ala Leu Arg 1 5 <210> SEQ ID NO 1936 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1936 Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 <210> SEQ ID NO 1937 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1937 Ser Ala Ile Cys Ser Val Val Arg 1 5 <210> SEQ ID NO 1938 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1938 Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 1939 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1939 Ser Ala Leu Asn Pro Ala Asp Asp Pro Ser Arg 1 5 10 <210> SEQ ID NO 1940 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1940 Ser Ala Ser Phe Cys Gly Ser Pro Tyr 1 5 <210> SEQ ID NO 1941 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1941 Ser Phe Pro Trp Leu Leu Gly Cys Ala 1 5 <210> SEQ ID NO 1942 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1942 Ser Phe Pro Trp Leu Leu Gly Cys Ala Ala 1 5 10 <210> SEQ ID NO 1943 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1943 Ser Leu Asp Val Ser Ala Ala Phe Tyr His 1 5 10 <210> SEQ ID NO 1944 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1944 Ser Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 10 <210> SEQ ID NO 1945 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1945 Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 1946 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1946 Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 1947 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1947 Ser Ser Ala Gly Pro Cys Ala Leu Arg 1 5 <210> SEQ ID NO 1948 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1948 Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 10 <210> SEQ ID NO 1949 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1949 Ser Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 1950 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1950 Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 1951 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1951 Ser Thr Asn Arg Gln Ser Gly Arg 1 5 <210> SEQ ID NO 1952 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1952 Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 1953 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1953 Ser Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 10 <210> SEQ ID NO 1954 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1954 Ser Val Val Arg Arg Ala Phe Pro His 1 5 <210> SEQ ID NO 1955 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1955 Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 <210> SEQ ID NO 1956 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1956 Thr Ala Glu Leu Leu Ala Ala Cys Phe Ala Arg 1 5 10 <210> SEQ ID NO 1957 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1957 Thr Asp Asn Ser Val Val Leu Ser Arg 1 5 <210> SEQ ID NO 1958 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1958 Thr Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 <210> SEQ ID NO 1959 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1959 Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 10 <210> SEQ ID NO 1960 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1960 Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 <210> SEQ ID NO 1961 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1961 Thr Gly Gly Val Phe Leu Val Asp Lys 1 5 <210> SEQ ID NO 1962 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1962 Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 <210> SEQ ID NO 1963 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1963 Thr Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 1964 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1964 Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg 1 5 10 <210> SEQ ID NO 1965 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1965 Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 1966 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1966 Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 1967 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1967 Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg 1 5 10 <210> SEQ ID NO 1968 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1968 Thr Ser Ala Ile Cys Ser Val Val Arg 1 5 <210> SEQ ID NO 1969 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1969 Thr Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 10 <210> SEQ ID NO 1970 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1970 Thr Ser Phe Pro Trp Leu Leu Gly Cys Ala 1 5 10 <210> SEQ ID NO 1971 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1971 Thr Ser Phe Val Tyr Val Pro Ser Ala 1 5 <210> SEQ ID NO 1972 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1972 Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 <210> SEQ ID NO 1973 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1973 Thr Thr Ser Thr Gly Pro Cys Lys 1 5 <210> SEQ ID NO 1974 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1974 Thr Thr Val Val Arg Arg Arg Gly Arg 1 5 <210> SEQ ID NO 1975 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1975 Thr Val Val Arg Arg Arg Gly Arg 1 5 <210> SEQ ID NO 1976 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1976 Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg 1 5 10 <210> SEQ ID NO 1977 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1977 Val Phe Leu Val Asp Lys Asn Pro His 1 5 <210> SEQ ID NO 1978 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1978 Val Phe Val Leu Gly Gly Cys Arg His 1 5 <210> SEQ ID NO 1979 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1979 Val Phe Val Leu Gly Gly Cys Arg His Lys 1 5 10 <210> SEQ ID NO 1980 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1980 Val Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 10 <210> SEQ ID NO 1981 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1981 Val Gly Pro Leu Thr Val Asn Glu Lys 1 5 <210> SEQ ID NO 1982 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1982 Val Gly Pro Leu Thr Val Asn Glu Lys Arg 1 5 10 <210> SEQ ID NO 1983 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1983 Val Leu Gly Ala Lys Ser Val Gln His 1 5 <210> SEQ ID NO 1984 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1984 Val Leu Gly Gly Cys Arg His Lys 1 5 <210> SEQ ID NO 1985 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1985 Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg 1 5 10 <210> SEQ ID NO 1986 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1986 Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 1987 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1987 Val Ser Phe Gly Val Trp Ile Arg 1 5 <210> SEQ ID NO 1988 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1988 Val Ser Ile Pro Trp Thr His Lys 1 5 <210> SEQ ID NO 1989 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1989 Val Thr Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 1990 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1990 Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 <210> SEQ ID NO 1991 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1991 Val Val Leu Gly Ala Lys Ser Val Gln His 1 5 10 <210> SEQ ID NO 1992 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1992 Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 1993 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1993 Val Val Arg Arg Arg Gly Arg Ser Pro Arg 1 5 10 <210> SEQ ID NO 1994 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1994 Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg 1 5 10 <210> SEQ ID NO 1995 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1995 Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 1996 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1996 Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 1997 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1997 Trp Gly Met Asp Ile Asp Pro Tyr Lys 1 5 <210> SEQ ID NO 1998 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1998 Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 10 <210> SEQ ID NO 1999 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1999 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 10 <210> SEQ ID NO 2000 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2000 Trp Ile Arg Thr Pro Pro Ala Tyr Arg 1 5 <210> SEQ ID NO 2001 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2001 Trp Leu Gln Phe Arg Asn Ser Lys 1 5 <210> SEQ ID NO 2002 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2002 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 <210> SEQ ID NO 2003 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2003 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 10 <210> SEQ ID NO 2004 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2004 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr Lys 1 5 10 <210> SEQ ID NO 2005 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2005 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 2006 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2006 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 2007 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2007 Tyr Leu Pro Leu Asp Lys Gly Ile Lys 1 5 <210> SEQ ID NO 2008 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2008 Tyr Leu Val Ser Phe Gly Val Trp Ile Arg 1 5 10 <210> SEQ ID NO 2009 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2009 Tyr Met Asp Asp Val Val Leu Gly Ala Lys 1 5 10 <210> SEQ ID NO 2010 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2010 Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 <210> SEQ ID NO 2011 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2011 Tyr Ser His Pro Ile Ile Leu Gly Phe Arg 1 5 10 <210> SEQ ID NO 2012 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2012 Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys 1 5 10 <210> SEQ ID NO 2013 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2013 Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 10 <210> SEQ ID NO 2014 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2014 Ala Phe Ser Tyr Met Asp Asp Val Val Leu 1 5 10 <210> SEQ ID NO 2015 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2015 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 2016 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2016 Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 <210> SEQ ID NO 2017 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2017 Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 1 5 10 <210> SEQ ID NO 2018 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2018 Glu Tyr Leu Val Ser Phe Gly Val Trp 1 5 <210> SEQ ID NO 2019 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2019 Glu Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 10 <210> SEQ ID NO 2020 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2020 Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 10 <210> SEQ ID NO 2021 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2021 Gly Phe Phe Leu Leu Thr Arg Ile Leu 1 5 <210> SEQ ID NO 2022 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2022 Gly Phe Leu Gly Pro Leu Leu Val Leu 1 5 <210> SEQ ID NO 2023 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2023 Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 <210> SEQ ID NO 2024 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2024 Gly Trp Ser Pro Gln Ala Gln Gly Ile 1 5 <210> SEQ ID NO 2025 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2025 Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu 1 5 10 <210> SEQ ID NO 2026 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2026 Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 1 5 10 <210> SEQ ID NO 2027 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2027 His Phe Ala Ser Pro Leu His Val Ala Trp 1 5 10 <210> SEQ ID NO 2028 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2028 Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 <210> SEQ ID NO 2029 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2029 Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 10 <210> SEQ ID NO 2030 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2030 Lys Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 10 <210> SEQ ID NO 2031 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2031 Lys Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 <210> SEQ ID NO 2032 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2032 Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 2033 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2033 Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 <210> SEQ ID NO 2034 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2034 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 2035 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2035 Leu Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 10 <210> SEQ ID NO 2036 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2036 Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 2037 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2037 Asn Phe Leu Leu Ser Leu Gly Ile His Leu 1 5 10 <210> SEQ ID NO 2038 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2038 Asn Trp Ile Leu Arg Gly Thr Ser Phe 1 5 <210> SEQ ID NO 2039 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2039 Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 10 <210> SEQ ID NO 2040 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2040 Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 <210> SEQ ID NO 2041 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2041 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 2042 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2042 Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 10 <210> SEQ ID NO 2043 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2043 Pro Trp Thr His Lys Val Gly Asn Phe 1 5 <210> SEQ ID NO 2044 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2044 Arg Phe Ile Ile Phe Leu Phe Ile Leu 1 5 <210> SEQ ID NO 2045 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2045 Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 10 <210> SEQ ID NO 2046 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2046 Arg Trp Met Cys Leu Arg Arg Phe Ile 1 5 <210> SEQ ID NO 2047 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2047 Arg Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 10 <210> SEQ ID NO 2048 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2048 Ser Phe Cys Gly Ser Pro Tyr Ser Trp 1 5 <210> SEQ ID NO 2049 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2049 Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 <210> SEQ ID NO 2050 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2050 Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 2051 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2051 Ser Trp Pro Lys Phe Ala Val Pro Asn Leu 1 5 10 <210> SEQ ID NO 2052 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2052 Ser Trp Trp Thr Ser Leu Asn Phe Leu 1 5 <210> SEQ ID NO 2053 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2053 Ser Tyr Gln His Phe Arg Lys Leu Leu 1 5 <210> SEQ ID NO 2054 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2054 Ser Tyr Gln His Phe Arg Lys Leu Leu Leu 1 5 10 <210> SEQ ID NO 2055 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2055 Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 <210> SEQ ID NO 2056 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2056 Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 10 <210> SEQ ID NO 2057 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2057 Val Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 10 <210> SEQ ID NO 2058 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2058 Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 2059 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2059 Trp Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 10 <210> SEQ ID NO 2060 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2060 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 2061 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2061 Ala Ala Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val Pro 1 5 10 15 <210> SEQ ID NO 2062 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2062 Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp 1 5 10 15 <210> SEQ ID NO 2063 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2063 Ala Glu Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg Ser Gly Ala 1 5 10 15 <210> SEQ ID NO 2064 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2064 Ala Phe Ser Tyr Met Asp Asp Val Val Leu Gly Ala Lys Ser Val 1 5 10 15 <210> SEQ ID NO 2065 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2065 Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser 1 5 10 15 <210> SEQ ID NO 2066 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2066 Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala Asp Glu Gly 1 5 10 15 <210> SEQ ID NO 2067 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2067 Ala Lys Leu Ile Gly Thr Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 15 <210> SEQ ID NO 2068 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2068 Ala Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val Pro Ser 1 5 10 15 <210> SEQ ID NO 2069 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2069 Ala Arg Asp Val Leu Cys Leu Arg Pro Val Gly Ala Glu Ser Arg 1 5 10 15 <210> SEQ ID NO 2070 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2070 Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 1 5 10 15 <210> SEQ ID NO 2071 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2071 Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp Gly Met Asp Ile Asp 1 5 10 15 <210> SEQ ID NO 2072 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2072 Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 10 15 <210> SEQ ID NO 2073 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2073 Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val Ser 1 5 10 15 <210> SEQ ID NO 2074 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2074 Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 15 <210> SEQ ID NO 2075 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2075 Cys Pro Thr Val Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp 1 5 10 15 <210> SEQ ID NO 2076 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2076 Cys Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu Ala 1 5 10 15 <210> SEQ ID NO 2077 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2077 Cys Ser Val Val Arg Arg Ala Phe Pro His Cys Leu Ala Phe Ser 1 5 10 15 <210> SEQ ID NO 2078 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2078 Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Arg Phe 1 5 10 15 <210> SEQ ID NO 2079 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2079 Cys Trp Trp Leu Gln Phe Arg Asn Ser Lys Pro Cys Ser Asp Tyr 1 5 10 15 <210> SEQ ID NO 2080 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2080 Asp Asp Val Val Leu Gly Ala Lys Ser Val Gln His Leu Glu Ser 1 5 10 15 <210> SEQ ID NO 2081 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2081 Asp Glu Gly Leu Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly 1 5 10 15 <210> SEQ ID NO 2082 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2082 Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp Thr His 1 5 10 15 <210> SEQ ID NO 2083 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2083 Asp Val Val Leu Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu 1 5 10 15 <210> SEQ ID NO 2084 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2084 Asp Trp Lys Val Cys Gln Arg Ile Val Gly Leu Leu Gly Phe Ala 1 5 10 15 <210> SEQ ID NO 2085 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2085 Glu Ile Arg Leu Lys Val Phe Val Leu Gly Gly Cys Arg His Lys 1 5 10 15 <210> SEQ ID NO 2086 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2086 Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg Gly Asn 1 5 10 15 <210> SEQ ID NO 2087 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2087 Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp 1 5 10 15 <210> SEQ ID NO 2088 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2088 Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn 1 5 10 15 <210> SEQ ID NO 2089 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2089 Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 15 <210> SEQ ID NO 2090 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2090 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 1 5 10 15 <210> SEQ ID NO 2091 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2091 Phe Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg Gly 1 5 10 15 <210> SEQ ID NO 2092 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2092 Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val Cys 1 5 10 15 <210> SEQ ID NO 2093 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2093 Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 15 <210> SEQ ID NO 2094 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2094 Phe Ser Tyr Met Asp Asp Val Val Leu Gly Ala Lys Ser Val Gln 1 5 10 15 <210> SEQ ID NO 2095 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2095 Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser 1 5 10 15 <210> SEQ ID NO 2096 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2096 Gly Ala His Leu Ser Leu Arg Gly Leu Pro Val Cys Ala Phe Ser 1 5 10 15 <210> SEQ ID NO 2097 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2097 Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 15 <210> SEQ ID NO 2098 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2098 Gly Ile His Leu Asn Pro Asn Lys Thr Lys Arg Trp Gly Tyr Ser 1 5 10 15 <210> SEQ ID NO 2099 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2099 Gly Leu Pro Val Cys Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 10 15 <210> SEQ ID NO 2100 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2100 Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn 1 5 10 15 <210> SEQ ID NO 2101 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2101 Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp 1 5 10 15 <210> SEQ ID NO 2102 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2102 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala Asp 1 5 10 15 <210> SEQ ID NO 2103 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2103 Gly Val Phe Leu Val Asp Lys Asn Pro His Asn Thr Thr Glu Ser 1 5 10 15 <210> SEQ ID NO 2104 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2104 Gly Val Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala 1 5 10 15 <210> SEQ ID NO 2105 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2105 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala 1 5 10 15 <210> SEQ ID NO 2106 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2106 His Gly Gly Leu Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu 1 5 10 15 <210> SEQ ID NO 2107 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2107 His Leu Pro Leu His Pro Ala Ala Met Pro His Leu Leu Val Gly 1 5 10 15 <210> SEQ ID NO 2108 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2108 His Leu Ser Leu Arg Gly Leu Pro Val Cys Ala Phe Ser Ser Ala 1 5 10 15 <210> SEQ ID NO 2109 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2109 His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 10 15 <210> SEQ ID NO 2110 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2110 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg Glu Thr Thr 1 5 10 15 <210> SEQ ID NO 2111 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2111 Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 10 15 <210> SEQ ID NO 2112 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2112 Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 15 <210> SEQ ID NO 2113 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2113 Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu Ser Pro 1 5 10 15 <210> SEQ ID NO 2114 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2114 Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 15 <210> SEQ ID NO 2115 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2115 Ile Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala 1 5 10 15 <210> SEQ ID NO 2116 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2116 Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly 1 5 10 15 <210> SEQ ID NO 2117 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2117 Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly 1 5 10 15 <210> SEQ ID NO 2118 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2118 Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile Leu 1 5 10 15 <210> SEQ ID NO 2119 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2119 Lys Phe Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu Leu Ser 1 5 10 15 <210> SEQ ID NO 2120 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2120 Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe Leu Leu Ala Gln 1 5 10 15 <210> SEQ ID NO 2121 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2121 Lys Leu His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys 1 5 10 15 <210> SEQ ID NO 2122 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2122 Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys 1 5 10 15 <210> SEQ ID NO 2123 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2123 Lys Gln Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 15 <210> SEQ ID NO 2124 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2124 Lys Arg Arg Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr Pro Asn 1 5 10 15 <210> SEQ ID NO 2125 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2125 Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg Ala 1 5 10 15 <210> SEQ ID NO 2126 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2126 Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 15 <210> SEQ ID NO 2127 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2127 Leu Cys Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 15 <210> SEQ ID NO 2128 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2128 Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro 1 5 10 15 <210> SEQ ID NO 2129 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2129 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu 1 5 10 15 <210> SEQ ID NO 2130 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2130 Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala 1 5 10 15 <210> SEQ ID NO 2131 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2131 Leu Gly Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys Val Gly 1 5 10 15 <210> SEQ ID NO 2132 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2132 Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr 1 5 10 15 <210> SEQ ID NO 2133 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2133 Leu Gly Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 15 <210> SEQ ID NO 2134 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2134 Leu His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 10 15 <210> SEQ ID NO 2135 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2135 Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg Glu Thr 1 5 10 15 <210> SEQ ID NO 2136 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2136 Leu Lys Val Phe Val Leu Gly Gly Cys Arg His Lys Leu Val Cys 1 5 10 15 <210> SEQ ID NO 2137 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2137 Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly 1 5 10 15 <210> SEQ ID NO 2138 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2138 Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro 1 5 10 15 <210> SEQ ID NO 2139 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2139 Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala 1 5 10 15 <210> SEQ ID NO 2140 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2140 Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr 1 5 10 15 <210> SEQ ID NO 2141 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2141 Leu Pro Lys Val Leu His Lys Arg Thr Leu Gly Leu Ser Ala Met 1 5 10 15 <210> SEQ ID NO 2142 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2142 Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile Glx 1 5 10 15 <210> SEQ ID NO 2143 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2143 Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 10 15 <210> SEQ ID NO 2144 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2144 Leu Ser Ala Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe Lys Asp 1 5 10 15 <210> SEQ ID NO 2145 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2145 Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg Gly Arg 1 5 10 15 <210> SEQ ID NO 2146 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2146 Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Ile 1 5 10 15 <210> SEQ ID NO 2147 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2147 Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp 1 5 10 15 <210> SEQ ID NO 2148 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2148 Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu 1 5 10 15 <210> SEQ ID NO 2149 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2149 Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val 1 5 10 15 <210> SEQ ID NO 2150 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2150 Met Gln Leu Phe His Leu Cys Leu Ile Ile Ser Cys Ser Cys Pro 1 5 10 15 <210> SEQ ID NO 2151 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2151 Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 10 15 <210> SEQ ID NO 2152 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2152 Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 15 <210> SEQ ID NO 2153 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2153 Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His 1 5 10 15 <210> SEQ ID NO 2154 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2154 Asn Arg Pro Ile Asp Trp Lys Val Cys Gln Arg Ile Val Gly Leu 1 5 10 15 <210> SEQ ID NO 2155 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2155 Pro Ala Ala Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser 1 5 10 15 <210> SEQ ID NO 2156 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2156 Pro Asp Arg Val His Phe Ala Ser Pro Leu His Val Ala Trp Arg 1 5 10 15 <210> SEQ ID NO 2157 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2157 Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val 1 5 10 15 <210> SEQ ID NO 2158 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2158 Pro His Cys Leu Ala Phe Ser Tyr Met Asp Asp Val Val Leu Gly 1 5 10 15 <210> SEQ ID NO 2159 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2159 Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu 1 5 10 15 <210> SEQ ID NO 2160 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2160 Pro Leu Pro Ile His Thr Ala Glu Leu Leu Ala Ala Cys Phe Ala 1 5 10 15 <210> SEQ ID NO 2161 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2161 Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu 1 5 10 15 <210> SEQ ID NO 2162 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2162 Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe His Gln Thr Leu 1 5 10 15 <210> SEQ ID NO 2163 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2163 Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly 1 5 10 15 <210> SEQ ID NO 2164 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2164 Gln Cys Gly Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln 1 5 10 15 <210> SEQ ID NO 2165 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2165 Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu 1 5 10 15 <210> SEQ ID NO 2166 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2166 Gln Gln Tyr Val Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 10 15 <210> SEQ ID NO 2167 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2167 Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 10 15 <210> SEQ ID NO 2168 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2168 Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 15 <210> SEQ ID NO 2169 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2169 Arg Asp Val Leu Cys Leu Arg Pro Val Gly Ala Glu Ser Arg Gly 1 5 10 15 <210> SEQ ID NO 2170 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2170 Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 15 <210> SEQ ID NO 2171 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2171 Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 15 <210> SEQ ID NO 2172 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2172 Arg Pro Gly Leu Cys Gln Val Phe Ala Asp Ala Thr Pro Thr Gly 1 5 10 15 <210> SEQ ID NO 2173 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2173 Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 1 5 10 15 <210> SEQ ID NO 2174 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2174 Arg Arg Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asp Asp 1 5 10 15 <210> SEQ ID NO 2175 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2175 Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 10 15 <210> SEQ ID NO 2176 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2176 Arg Arg Ser Phe Gly Val Glu Pro Ser Gly Ser Gly His Ile Asp 1 5 10 15 <210> SEQ ID NO 2177 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2177 Arg Val Ser Trp Pro Lys Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 10 15 <210> SEQ ID NO 2178 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2178 Arg Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val Ile Gly Ser 1 5 10 15 <210> SEQ ID NO 2179 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2179 Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro 1 5 10 15 <210> SEQ ID NO 2180 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2180 Ser Phe Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg 1 5 10 15 <210> SEQ ID NO 2181 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2181 Ser Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala Asp Asp Pro 1 5 10 15 <210> SEQ ID NO 2182 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2182 Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 15 <210> SEQ ID NO 2183 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2183 Ser Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val 1 5 10 15 <210> SEQ ID NO 2184 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2184 Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 15 <210> SEQ ID NO 2185 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2185 Ser Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser 1 5 10 15 <210> SEQ ID NO 2186 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2186 Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln 1 5 10 15 <210> SEQ ID NO 2187 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2187 Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 10 15 <210> SEQ ID NO 2188 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2188 Thr Asn Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 10 15 <210> SEQ ID NO 2189 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2189 Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp Val 1 5 10 15 <210> SEQ ID NO 2190 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2190 Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr 1 5 10 15 <210> SEQ ID NO 2191 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2191 Thr Ser Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala Asp Asp 1 5 10 15 <210> SEQ ID NO 2192 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2192 Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 10 15 <210> SEQ ID NO 2193 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2193 Val Ala Pro Leu Pro Ile His Thr Ala Glu Leu Leu Ala Ala Cys 1 5 10 15 <210> SEQ ID NO 2194 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2194 Val Cys Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe Thr 1 5 10 15 <210> SEQ ID NO 2195 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2195 Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile 1 5 10 15 <210> SEQ ID NO 2196 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2196 Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 10 15 <210> SEQ ID NO 2197 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2197 Val Gly Asn Phe Thr Gly Leu Tyr Ser Ser Thr Val Pro Val Phe 1 5 10 15 <210> SEQ ID NO 2198 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2198 Val Leu Cys Leu Arg Pro Val Gly Ala Glu Ser Arg Gly Arg Pro 1 5 10 15 <210> SEQ ID NO 2199 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2199 Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val 1 5 10 15 <210> SEQ ID NO 2200 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2200 Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 10 15 <210> SEQ ID NO 2201 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2201 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Ile Pro Leu 1 5 10 15 <210> SEQ ID NO 2202 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2202 Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 10 15 <210> SEQ ID NO 2203 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2203 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 10 15 <210> SEQ ID NO 2204 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2204 Trp Pro Lys Phe Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu 1 5 10 15 <210> SEQ ID NO 2205 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2205 Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser Lys Gln 1 5 10 15 <210> SEQ ID NO 2206 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2206 Ala Phe Ser Tyr Met Asp Asp Val Val Leu Gly Ala Lys Ser Val 1 5 10 15 <210> SEQ ID NO 2207 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2207 Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys Gln 1 5 10 15 <210> SEQ ID NO 2208 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2208 Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala Asp Glu Gly 1 5 10 15 <210> SEQ ID NO 2209 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2209 Ala Lys Leu Ile Gly Thr Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 15 <210> SEQ ID NO 2210 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2210 Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 1 5 10 15 <210> SEQ ID NO 2211 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2211 Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val Ser 1 5 10 15 <210> SEQ ID NO 2212 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2212 Asp His Gly Ala His Leu Ser Leu Arg Gly Leu Pro Val Cys Ala 1 5 10 15 <210> SEQ ID NO 2213 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2213 Asp Asn Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 10 15 <210> SEQ ID NO 2214 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2214 Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg Gly Asn 1 5 10 15 <210> SEQ ID NO 2215 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2215 Phe His Gln Ala Val Leu Asp Pro Arg Val Arg Gly Leu Tyr Leu 1 5 10 15 <210> SEQ ID NO 2216 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2216 Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys 1 5 10 15 <210> SEQ ID NO 2217 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2217 Gly Gly Val Phe Leu Val Asp Lys Asn Pro His Asn Thr Thr Glu 1 5 10 15 <210> SEQ ID NO 2218 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2218 Leu Cys Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 15 <210> SEQ ID NO 2219 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2219 Leu Arg Pro Val Gly Ala Glu Ser Arg Gly Arg Pro Val Ser Gly 1 5 10 15 <210> SEQ ID NO 2220 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2220 Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Ile 1 5 10 15 <210> SEQ ID NO 2221 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2221 Leu Trp Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser 1 5 10 15 <210> SEQ ID NO 2222 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2222 Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val 1 5 10 15 <210> SEQ ID NO 2223 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2223 Asn Val Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr Gly 1 5 10 15 <210> SEQ ID NO 2224 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2224 Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly 1 5 10 15 <210> SEQ ID NO 2225 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2225 Arg Arg Ser Phe Gly Val Glu Pro Ser Gly Ser Gly His Ile Asp 1 5 10 15 <210> SEQ ID NO 2226 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2226 Thr Lys Tyr Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr Pro 1 5 10 15 <210> SEQ ID NO 2227 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2227 Val Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Lys Leu Ile 1 5 10 15 <210> SEQ ID NO 2228 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2228 Tyr Met Asp Asp Val Val Leu Gly Ala 1 5 <210> SEQ ID NO 2229 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2229 Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 <210> SEQ ID NO 2230 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2230 Leu Glu Glu Glu Leu Pro Arg Leu Ala 1 5 <210> SEQ ID NO 2231 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2231 Ile Gly Thr Asp Asn Ser Val Val Leu 1 5 <210> SEQ ID NO 2232 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2232 Leu Tyr Arg Glu Ala Leu Glu Ser Pro 1 5 <210> SEQ ID NO 2233 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2233 Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 <210> SEQ ID NO 2234 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2234 Ala His Leu Ser Leu Arg Gly Leu Pro 1 5 <210> SEQ ID NO 2235 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2235 Val Val Leu Ser Arg Lys Tyr Thr Ser 1 5 <210> SEQ ID NO 2236 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2236 Leu Val Val Asp Phe Ser Gln Phe Ser 1 5 <210> SEQ ID NO 2237 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2237 Ala Val Leu Asp Pro Arg Val Arg Gly 1 5 <210> SEQ ID NO 2238 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2238 Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 <210> SEQ ID NO 2239 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2239 Phe Leu Val Asp Lys Asn Pro His Asn 1 5 <210> SEQ ID NO 2240 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2240 Val Phe Ala Asp Ala Thr Pro Thr Gly 1 5 <210> SEQ ID NO 2241 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2241 Val Gly Ala Glu Ser Arg Gly Arg Pro 1 5 <210> SEQ ID NO 2242 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2242 Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 2243 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2243 Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 2244 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2244 Val Ala Glu Asp Leu Asn Leu Gly Asn 1 5 <210> SEQ ID NO 2245 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2245 Ile Pro Trp Thr His Lys Val Gly Asn 1 5 <210> SEQ ID NO 2246 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2246 Phe Phe Pro Asp His Gln Leu Asp Pro 1 5 <210> SEQ ID NO 2247 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2247 Phe Gly Val Glu Pro Ser Gly Ser Gly 1 5 <210> SEQ ID NO 2248 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2248 Leu Pro Leu Asp Lys Gly Ile Lys Pro 1 5 <210> SEQ ID NO 2249 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2249 Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 2250 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2250 Ala Leu Phe Lys Asp Trp Glu Glu Leu 1 5 <210> SEQ ID NO 2251 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV9 <400> SEQUENCE: 2251 Ala Leu Met Pro Leu Tyr Ala Cys Val 1 5 <210> SEQ ID NO 2252 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2252 Ala Leu Met Pro Leu Tyr Ala Ser Ile 1 5 <210> SEQ ID NO 2253 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2253 Ala Leu Met Pro Leu Tyr Ala Xaa Ile 1 5 <210> SEQ ID NO 2254 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2254 Ala Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2255 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 10 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2255 Ala Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2256 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2256 Ala Leu Ser Leu Ile Val Asn Leu Leu 1 5 <210> SEQ ID NO 2257 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2257 Ala Met Thr Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 2258 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 17 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2258 Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser 1 5 10 15 Xaa <210> SEQ ID NO 2259 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2259 Cys Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 2260 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2260 Cys Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 2261 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2261 Asp Pro Phe Arg Gly Arg Leu Gly Leu 1 5 <210> SEQ ID NO 2262 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2262 Asp Pro Ser Arg Gly Arg Leu Gly Ile 1 5 <210> SEQ ID NO 2263 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 14 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2263 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2264 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide LA2.V10 <400> SEQUENCE: 2264 Phe Ala Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2265 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2265 Phe Ile Leu Leu Leu Xaa Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 2266 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2266 Phe Leu Ala Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2267 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.LV1 <400> SEQUENCE: 2267 Phe Leu Gly Leu Ser Pro Thr Val Trp Val 1 5 10 <210> SEQ ID NO 2268 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2268 Phe Leu Lys Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2269 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV10 <400> SEQUENCE: 2269 Phe Leu Leu Ala Gln Phe Thr Ser Ala Val 1 5 10 <210> SEQ ID NO 2270 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.AV9 <400> SEQUENCE: 2270 Phe Leu Leu Ala Gln Phe Thr Ser Val 1 5 <210> SEQ ID NO 2271 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2271 Phe Leu Leu Pro Ile Phe Phe Cys Leu 1 5 <210> SEQ ID NO 2272 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2272 Phe Leu Leu Ser Leu Gly Ile His Val 1 5 <210> SEQ ID NO 2273 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV9 <400> SEQUENCE: 2273 Phe Leu Leu Thr Arg Ile Leu Thr Val 1 5 <210> SEQ ID NO 2274 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2274 Phe Leu Leu Thr Arg Ile Leu Tyr Ile 1 5 <210> SEQ ID NO 2275 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2275 Phe Leu Leu Thr Tyr Ile Leu Thr Ile 1 5 <210> SEQ ID NO 2276 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2276 Phe Leu Met Ser Asp Tyr Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2277 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2277 Phe Leu Met Ser Tyr Phe Pro Ser Val 1 5 <210> SEQ ID NO 2278 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.SA4 <400> SEQUENCE: 2278 Phe Leu Pro Ala Asp Phe Phe Pro Ser Ile 1 5 10 <210> SEQ ID NO 2279 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2279 Phe Leu Pro Ala Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2280 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.SD4 <400> SEQUENCE: 2280 Phe Leu Pro Asp Asp Phe Phe Pro Ser Ala 1 5 10 <210> SEQ ID NO 2281 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2281 Phe Leu Pro Asp Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2282 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.SN4 <400> SEQUENCE: 2282 Phe Leu Pro Asn Asp Phe Phe Pro Ser Ala 1 5 10 <210> SEQ ID NO 2283 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2283 Phe Leu Pro Asn Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2284 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2284 Phe Leu Pro Ser Xaa Tyr Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2285 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2285 Phe Leu Pro Ser Ala Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2286 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2286 Phe Leu Pro Ser Asp Xaa Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2287 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2287 Phe Leu Pro Ser Asp Ala Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2288 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2288 Phe Leu Pro Ser Asp Phe Ala Pro Ser Val 1 5 10 <210> SEQ ID NO 2289 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 7 <223> OTHER INFORMATION: Xaa=F-NH-2 <400> SEQUENCE: 2289 Phe Leu Pro Ser Asp Phe Xaa 1 5 <210> SEQ ID NO 2290 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2290 Phe Leu Pro Ser Asp Phe Phe Ala Ser Val 1 5 10 <210> SEQ ID NO 2291 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2291 Phe Leu Pro Ser Asp Phe Phe Lys Ser Val 1 5 10 <210> SEQ ID NO 2292 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2292 Phe Leu Pro Ser Asp Phe Phe Pro 1 5 <210> SEQ ID NO 2293 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8 <223> OTHER INFORMATION: Xaa=P-NH-2 <400> SEQUENCE: 2293 Phe Leu Pro Ser Asp Phe Phe Xaa 1 5 <210> SEQ ID NO 2294 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2294 Phe Leu Pro Ser Asp Phe Phe Pro Ala Val 1 5 10 <210> SEQ ID NO 2295 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2295 Phe Leu Pro Ser Asp Phe Phe Pro Lys Val 1 5 10 <210> SEQ ID NO 2296 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2296 Phe Leu Pro Ser Asp Phe Phe Pro Ser 1 5 <210> SEQ ID NO 2297 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 9 <223> OTHER INFORMATION: Xaa=S-NH2 <400> SEQUENCE: 2297 Phe Leu Pro Ser Asp Phe Phe Pro Xaa 1 5 <210> SEQ ID NO 2298 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.VA10 <400> SEQUENCE: 2298 Phe Leu Pro Ser Asp Phe Phe Pro Ser Ala 1 5 10 <210> SEQ ID NO 2299 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.VI10 <400> SEQUENCE: 2299 Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile 1 5 10 <210> SEQ ID NO 2300 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 10 <223> OTHER INFORMATION: Xaa=V(CONH2) <400> SEQUENCE: 2300 Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2301 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 10 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2301 Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2302 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2302 Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg 1 5 10 <210> SEQ ID NO 2303 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 11 <223> OTHER INFORMATION: Xaa=R-NH-2 <400> SEQUENCE: 2303 Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Xaa 1 5 10 <210> SEQ ID NO 2304 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2304 Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp 1 5 10 <210> SEQ ID NO 2305 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2305 Phe Leu Pro Ser Asp Phe Tyr Pro Ser Val 1 5 10 <210> SEQ ID NO 2306 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2306 Phe Leu Pro Ser Asp Leu Leu Pro Ser Val Arg 1 5 10 <210> SEQ ID NO 2307 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2307 Phe Leu Pro Ser Asp Tyr Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2308 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2308 Phe Leu Pro Ser Glu Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2309 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.FY5 <400> SEQUENCE: 2309 Phe Leu Pro Ser Tyr Phe Pro Ser Ala 1 5 <210> SEQ ID NO 2310 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.FY5 <400> SEQUENCE: 2310 Phe Leu Pro Ser Tyr Phe Pro Ser Val 1 5 <210> SEQ ID NO 2311 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2311 Phe Leu Pro Ser Glx Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2312 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2312 Phe Leu Pro Ser Glx Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2313 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.5V4 <400> SEQUENCE: 2313 Phe Leu Pro Val Asp Phe Phe Pro Ser Ile 1 5 10 <210> SEQ ID NO 2314 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2314 Phe Leu Pro Val Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2315 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2315 Phe Leu Ser Lys Gln Tyr Leu Asn Leu 1 5 <210> SEQ ID NO 2316 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2316 Phe Leu Tyr Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 2317 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2317 Phe Met Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 2318 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide IM2.L10 <400> SEQUENCE: 2318 Phe Met Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 2319 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide LM2.V1 <400> SEQUENCE: 2319 Phe Met Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2320 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2320 Phe Pro Ala Ala Met Pro His Leu 1 5 <210> SEQ ID NO 2321 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2321 Phe Pro Ala Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 2322 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2322 Phe Pro Ala Ala Met Pro His Leu Leu Val 1 5 10 <210> SEQ ID NO 2323 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2323 Phe Pro Ala Leu Met Pro Leu Tyr Ala 1 5 <210> SEQ ID NO 2324 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2324 Phe Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 2325 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2325 Phe Pro Cys Ala Leu Arg Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 2326 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2326 Phe Pro Phe Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 2327 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2327 Phe Pro Phe Cys Leu Ala Phe Ser Tyr Met 1 5 10 <210> SEQ ID NO 2328 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2328 Phe Pro His Cys Leu Ala Phe Ala Leu 1 5 <210> SEQ ID NO 2329 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2329 Phe Pro His Cys Leu Ala Phe Ala Tyr 1 5 <210> SEQ ID NO 2330 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2330 Phe Pro His Cys Leu Ala Phe Ser Ala 1 5 <210> SEQ ID NO 2331 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2331 Phe Pro His Cys Leu Ala Phe Ser Ile 1 5 <210> SEQ ID NO 2332 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2332 Phe Pro His Cys Leu Ala Phe Ser Leu 1 5 <210> SEQ ID NO 2333 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2333 Phe Pro His Cys Leu Ala Phe Ser Tyr Ile 1 5 10 <210> SEQ ID NO 2334 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2334 Phe Pro His Xaa Leu Ala Phe Ser Tyr Met 1 5 10 <210> SEQ ID NO 2335 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2335 Phe Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2336 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2336 Phe Pro Ser Arg Gly Arg Leu Gly Leu 1 5 <210> SEQ ID NO 2337 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2337 Phe Pro Val Cys Ala Phe Ser Ser Ala 1 5 <210> SEQ ID NO 2338 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2338 Phe Pro Val Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 2339 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2339 Phe Gln Pro Ser Asp Tyr Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2340 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2340 Phe Val Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 2341 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2341 Phe Val Leu Gly Gly Xaa Arg His Lys 1 5 <210> SEQ ID NO 2342 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.AV9 <400> SEQUENCE: 2342 Gly Leu Cys Gln Val Phe Ala Asp Val 1 5 <210> SEQ ID NO 2343 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.AV9 <400> SEQUENCE: 2343 Gly Leu Leu Gly Trp Ser Pro Gln Val 1 5 <210> SEQ ID NO 2344 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.AV9 <400> SEQUENCE: 2344 Gly Leu Trp Ile Arg Thr Pro Pro Val 1 5 <210> SEQ ID NO 2345 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 3 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2345 Gly Leu Xaa Gln Val Phe Ala Asp Ala 1 5 <210> SEQ ID NO 2346 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2346 Gly Met Asp Asn Ser Val Val Leu Ser Arg 1 5 10 <210> SEQ ID NO 2347 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2347 Gly Met Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 <210> SEQ ID NO 2348 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2348 Gly Pro Cys Ala Leu Arg Phe Thr Ser Ile 1 5 10 <210> SEQ ID NO 2349 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2349 Gly Pro Phe Ala Leu Arg Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 2350 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 3 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2350 Gly Pro Xaa Ala Leu Arg Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 2351 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2351 Gly Thr Phe Asn Ser Val Val Leu Ser Arg 1 5 10 <210> SEQ ID NO 2352 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2352 Gly Thr Phe Asn Ser Val Val Leu Ser Arg Lys 1 5 10 <210> SEQ ID NO 2353 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2353 Gly Val Asp Asn Ser Val Val Leu Ser Arg 1 5 10 <210> SEQ ID NO 2354 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2354 Gly Val Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 <210> SEQ ID NO 2355 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2355 Gly Tyr Arg Trp Met Xaa Leu Arg Arg Phe 1 5 10 <210> SEQ ID NO 2356 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2356 His Ile Ser Xaa Leu Thr Phe Gly Arg 1 5 <210> SEQ ID NO 2357 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2357 His Met Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 2358 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2358 His Met Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 2359 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2359 His Pro Ala Ala Met Pro His Ile 1 5 <210> SEQ ID NO 2360 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2360 His Pro Ala Ala Met Pro His Leu Ile 1 5 <210> SEQ ID NO 2361 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2361 His Pro Ala Ala Met Pro His Leu Leu Ile 1 5 10 <210> SEQ ID NO 2362 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2362 His Pro Phe Ala Met Pro His Leu 1 5 <210> SEQ ID NO 2363 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2363 His Pro Phe Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 2364 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2364 His Pro Phe Ala Met Pro His Leu Leu Val 1 5 10 <210> SEQ ID NO 2365 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2365 His Thr Leu Trp Lys Ala Gly Ile Leu Lys 1 5 10 <210> SEQ ID NO 2366 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2366 His Thr Leu Trp Lys Ala Gly Ile Leu Arg 1 5 10 <210> SEQ ID NO 2367 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2367 His Val Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 2368 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2368 His Val Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 2369 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2369 Ile Ile Lys Lys Ser Glu Gln Phe Val 1 5 <210> SEQ ID NO 2370 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.AV9 <400> SEQUENCE: 2370 Ile Leu Gly Leu Leu Gly Phe Ala Val 1 5 <210> SEQ ID NO 2371 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV10 <400> SEQUENCE: 2371 Ile Leu Leu Leu Cys Leu Ile Phe Leu Val 1 5 10 <210> SEQ ID NO 2372 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2372 Ile Leu Leu Leu Xaa Leu Ile Phe Leu 1 5 <210> SEQ ID NO 2373 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2373 Ile Leu Leu Leu Xaa Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 2374 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2374 Ile Pro Phe Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2375 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2375 Ile Pro Ile Leu Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2376 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2376 Ile Pro Ile Pro Met Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2377 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2377 Ile Pro Ile Pro Ser Ser Trp Ala Ile 1 5 <210> SEQ ID NO 2378 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2378 Ile Pro Ile Thr Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2379 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2379 Lys Ile Lys Glu Ser Phe Arg Lys Leu 1 5 <210> SEQ ID NO 2380 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2380 Lys Leu Phe Leu Tyr Ser His Pro Ile 1 5 <210> SEQ ID NO 2381 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV9 <400> SEQUENCE: 2381 Lys Leu His Leu Tyr Ser His Pro Val 1 5 <210> SEQ ID NO 2382 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2382 Lys Val Gly Asn Phe Thr Gly Leu Lys 1 5 <210> SEQ ID NO 2383 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2383 Lys Val Gly Asn Phe Thr Gly Leu Arg 1 5 <210> SEQ ID NO 2384 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV9 <400> SEQUENCE: 2384 Leu Leu Ala Gln Phe Thr Ser Ala Val 1 5 <210> SEQ ID NO 2385 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2385 Leu Leu Phe Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 2386 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2386 Leu Leu Gly Ser Ala Ala Asn Trp Ile 1 5 <210> SEQ ID NO 2387 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2387 Leu Leu Gly Xaa Ala Ala Asn Trp Ile Leu 1 5 10 <210> SEQ ID NO 2388 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2388 Leu Leu Leu Xaa Leu Ile Phe Leu Leu 1 5 <210> SEQ ID NO 2389 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2389 Leu Leu Leu Xaa Leu Ile Phe Leu Leu Val 1 5 10 <210> SEQ ID NO 2390 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2390 Leu Leu Leu Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 2391 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.V9 <400> SEQUENCE: 2391 Leu Leu Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 2392 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 7 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2392 Leu Leu Pro Ile Phe Phe Xaa Leu Trp Val 1 5 10 <210> SEQ ID NO 2393 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 13 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2393 Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2394 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2394 Leu Leu Ser Ser Asn Leu Ser Trp Val 1 5 <210> SEQ ID NO 2395 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV10 <400> SEQUENCE: 2395 Leu Leu Val Leu Gln Ala Gly Phe Phe Val 1 5 10 <210> SEQ ID NO 2396 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 3 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2396 Leu Leu Xaa Leu Ile Phe Leu Leu Val 1 5 <210> SEQ ID NO 2397 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VM2.LV <400> SEQUENCE: 2397 Leu Met Leu Leu Asp Tyr Gln Gly Met Val 1 5 10 <210> SEQ ID NO 2398 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VM2.LV <400> SEQUENCE: 2398 Leu Met Leu Gln Ala Gly Phe Phe Leu Val 1 5 10 <210> SEQ ID NO 2399 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VM2.V9 <400> SEQUENCE: 2399 Leu Met Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 2400 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2400 Leu Pro Phe Cys Ala Phe Ser Ser Ala 1 5 <210> SEQ ID NO 2401 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2401 Leu Pro Ile Phe Phe Cys Leu Ile 1 5 <210> SEQ ID NO 2402 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2402 Leu Pro Ile Phe Phe Cys Leu Trp Ile 1 5 <210> SEQ ID NO 2403 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2403 Leu Pro Ile His Thr Ala Glu Leu Ile 1 5 <210> SEQ ID NO 2404 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2404 Leu Pro Ile His Thr Ala Glu Leu Leu Ala Ile 1 5 10 <210> SEQ ID NO 2405 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 9 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2405 Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 <210> SEQ ID NO 2406 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2406 Leu Pro Val Cys Ala Phe Ser Ser Ile 1 5 <210> SEQ ID NO 2407 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2407 Leu Pro Val Xaa Ala Phe Ser Ser Ala 1 5 <210> SEQ ID NO 2408 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2408 Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2409 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 12 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2409 Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2410 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2410 Met Met Trp Tyr Trp Gly Pro Ser Leu Lys 1 5 10 <210> SEQ ID NO 2411 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2411 Met Met Trp Tyr Trp Gly Pro Ser Leu Arg 1 5 10 <210> SEQ ID NO 2412 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide M2.LV9 <400> SEQUENCE: 2412 Met Met Trp Tyr Trp Gly Pro Ser Val 1 5 <210> SEQ ID NO 2413 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2413 Met Pro Leu Ser Tyr Gln His Ile 1 5 <210> SEQ ID NO 2414 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV9 <400> SEQUENCE: 2414 Asn Leu Gly Asn Leu Asn Val Ser Val 1 5 <210> SEQ ID NO 2415 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2415 Asn Leu Asn Asn Leu Asn Val Ser Ile 1 5 <210> SEQ ID NO 2416 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2416 Asn Met Gly Leu Lys Tyr Arg Gln Leu 1 5 <210> SEQ ID NO 2417 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2417 Asn Pro Leu Gly Phe Phe Pro Asp His Gln Ile 1 5 10 <210> SEQ ID NO 2418 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2418 Pro Leu Leu Pro Ile Phe Phe Cys Val 1 5 <210> SEQ ID NO 2419 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2419 Pro Leu Leu Pro Ile Phe Phe Xaa Leu 1 5 <210> SEQ ID NO 2420 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2420 Pro Ser Asp Phe Phe Pro Ser Val 1 5 <210> SEQ ID NO 2421 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2421 Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 <210> SEQ ID NO 2422 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 9 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2422 Gln Leu Leu Trp Phe His Ile Ser Xaa Leu 1 5 10 <210> SEQ ID NO 2423 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2423 Gln Met Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 10 <210> SEQ ID NO 2424 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2424 Gln Val Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 10 <210> SEQ ID NO 2425 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2425 Arg Ile Pro Arg Thr Pro Arg Ser Val 1 5 <210> SEQ ID NO 2426 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.V9 <400> SEQUENCE: 2426 Arg Leu Ser Trp Pro Lys Phe Ala Val 1 5 <210> SEQ ID NO 2427 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.V9 <400> SEQUENCE: 2427 Arg Leu Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 2428 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide IM2.LV9 <400> SEQUENCE: 2428 Arg Met Leu Thr Ile Pro Gln Ser Val 1 5 <210> SEQ ID NO 2429 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VM2.V9 <400> SEQUENCE: 2429 Arg Met Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 2430 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2430 Arg Met Tyr Leu His Thr Leu Trp Lys 1 5 <210> SEQ ID NO 2431 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2431 Arg Val Tyr Leu His Thr Leu Trp Lys 1 5 <210> SEQ ID NO 2432 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2432 Ser Ala Ile Xaa Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 2433 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2433 Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2434 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 11 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2434 Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2435 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2435 Ser Leu Asp Ser Trp Trp Thr Ser Val 1 5 <210> SEQ ID NO 2436 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 10 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2436 Ser Leu Asn Phe Leu Gly Gly Thr Thr Xaa 1 5 10 <210> SEQ ID NO 2437 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2437 Ser Met Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 2438 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2438 Ser Met Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 2439 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2439 Ser Met Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2440 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide IM2.LV1 <400> SEQUENCE: 2440 Ser Met Leu Ser Pro Phe Leu Pro Leu Val 1 5 10 <210> SEQ ID NO 2441 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2441 Ser Pro Phe Leu Leu Ala Gln Ile 1 5 <210> SEQ ID NO 2442 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2442 Ser Thr Leu Pro Glu Thr Tyr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2443 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2443 Ser Val Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 2444 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2444 Ser Val Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 2445 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2445 Ser Val Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2446 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2446 Ser Val Asn Arg Pro Ile Asp Trp Lys 1 5 <210> SEQ ID NO 2447 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2447 Ser Val Val Arg Arg Ala Phe Pro Lys 1 5 <210> SEQ ID NO 2448 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2448 Ser Val Val Arg Arg Ala Phe Pro Arg 1 5 <210> SEQ ID NO 2449 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2449 Thr Leu Trp Lys Ala Gly Ile Leu Lys 1 5 <210> SEQ ID NO 2450 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2450 Thr Leu Trp Lys Ala Gly Ile Leu Arg 1 5 <210> SEQ ID NO 2451 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2451 Thr Met Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2452 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2452 Thr Met Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 2453 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2453 Thr Met Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 2454 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2454 Thr Pro Ala Arg Val Thr Gly Gly Val Ile 1 5 10 <210> SEQ ID NO 2455 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2455 Thr Pro Phe Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 2456 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2456 Thr Ser Ala Ile Xaa Ser Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2457 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 16 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2457 Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 15 <210> SEQ ID NO 2458 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2458 Thr Val Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2459 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2459 Thr Val Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 2460 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2460 Thr Val Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 2461 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 15 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2461 Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 15 <210> SEQ ID NO 2462 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 10 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2462 Val Leu Glu Tyr Leu Val Ser Phe Gly Xaa 1 5 10 <210> SEQ ID NO 2463 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2463 Val Leu Gly Gly Ser Arg His Lys Leu 1 5 <210> SEQ ID NO 2464 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2464 Val Leu Leu Asp Tyr Gln Gly Met Val 1 5 <210> SEQ ID NO 2465 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2465 Val Leu Gln Ala Gly Phe Phe Leu Val 1 5 <210> SEQ ID NO 2466 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2466 Val Met Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 2467 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2467 Val Pro Phe Val Gln Trp Phe Val Gly Ile 1 5 10 <210> SEQ ID NO 2468 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2468 Val Pro Ser Ala Leu Asn Pro Ile 1 5 <210> SEQ ID NO 2469 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2469 Val Val Phe Phe Ser Gln Phe Ser Arg 1 5 <210> SEQ ID NO 2470 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2470 Val Val Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 2471 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide IL2.V9 <400> SEQUENCE: 2471 Trp Leu Leu Arg Gly Thr Ser Phe Val 1 5 <210> SEQ ID NO 2472 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: clostridium tetani <400> SEQUENCE: 2472 Tyr Leu Phe Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 2473 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV10 <400> SEQUENCE: 2473 Tyr Leu His Thr Leu Trp Lys Ala Gly Val 1 5 10 <210> SEQ ID NO 2474 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2474 Tyr Leu Leu Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 2475 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2475 Tyr Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 2476 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.AV9 <400> SEQUENCE: 2476 Tyr Leu Pro Ser Ala Leu Asn Pro Val 1 5 <210> SEQ ID NO 2477 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2477 Tyr Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2478 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide M2.AV9 <400> SEQUENCE: 2478 Tyr Met Asp Asp Val Val Leu Gly Val 1 5 <210> SEQ ID NO 2479 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2479 Tyr Met Phe Asp Val Val Leu Gly Ala 1 5 <210> SEQ ID NO 2480 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2480 Tyr Met Phe Asp Val Val Leu Gly Ala Lys 1 5 10 <210> SEQ ID NO 2481 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2481 Tyr Asn Met Gly Leu Lys Phe Arg Gln Leu 1 5 10 <210> SEQ ID NO 2482 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2482 Tyr Pro Ala Leu Met Pro Leu Ile 1 5 <210> SEQ ID NO 2483 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2483 Tyr Pro Ala Leu Met Pro Leu Tyr Ile 1 5 <210> SEQ ID NO 2484 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2484 Tyr Pro Phe Leu Met Pro Leu Tyr Ala 1 5 <210> SEQ ID NO 2485 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2485 Tyr Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2486 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*0101 <400> SEQUENCE: 2486 Tyr Leu Glu Pro Ala Ile Ala Lys Tyr 1 5 <210> SEQ ID NO 2487 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to multiple HLAs <400> SEQUENCE: 2487 Phe Leu Pro Ser Asp Tyr Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2488 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*6802 <400> SEQUENCE: 2488 Phe Thr Gln Ala Gly Tyr Pro Ala Leu 1 5 <210> SEQ ID NO 2489 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*0301, A*6801 <400> SEQUENCE: 2489 Lys Val Phe Pro Tyr Ala Leu Ile Asn Lys 1 5 10 <210> SEQ ID NO 2490 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*1101 <400> SEQUENCE: 2490 Ala Val Asp Leu Tyr His Phe Leu Lys 1 5 <210> SEQ ID NO 2491 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*3301 <400> SEQUENCE: 2491 Ser Thr Leu Pro Glu Thr Tyr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2492 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*2401 <400> SEQUENCE: 2492 Ala Tyr Ile Asp Asn Tyr Asn Lys Phe 1 5 <210> SEQ ID NO 2493 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA B*0702 <400> SEQUENCE: 2493 Ala Pro Arg Thr Leu Val Tyr Leu Leu 1 5 <210> SEQ ID NO 2494 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA B*3501, B51, B*5301, B*5401 <400> SEQUENCE: 2494 Phe Pro Phe Lys Tyr Ala Ala Ala Phe 1 5 <210> SEQ ID NO 2495 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*0101, DRB1*0401 <400> SEQUENCE: 2495 Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 1 5 10 <210> SEQ ID NO 2496 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*0301 <400> SEQUENCE: 2496 Tyr Lys Thr Ile Ala Phe Asp Glu Glu Ala Arg Arg 1 5 10 <210> SEQ ID NO 2497 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*0404, DRB1*0405 <400> SEQUENCE: 2497 Tyr Ala Arg Phe Gln Ser Gln Thr Thr Leu Lys Gln Lys Thr 1 5 10 <210> SEQ ID NO 2498 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to multiple HLA DRB1s <400> SEQUENCE: 2498 Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 1 5 10 <210> SEQ ID NO 2499 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*1201 <400> SEQUENCE: 2499 Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu Ser 1 5 10 15 <210> SEQ ID NO 2500 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*1302 <400> SEQUENCE: 2500 Gln Tyr Ile Lys Ala Asn Ala Lys Phe Ile Gly Ile Thr Glu 1 5 10 <210> SEQ ID NO 2501 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*1501 <400> SEQUENCE: 2501 Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile 1 5 10 15 Val Thr Pro Arg Thr Pro Pro Pro 20 <210> SEQ ID NO 2502 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB3*0101 <400> SEQUENCE: 2502 Asn Gly Gln Ile Gly Asn Asp Pro Asn Arg Asp Ile Leu 1 5 10 <210> SEQ ID NO 2503 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB4*0101 <400> SEQUENCE: 2503 Tyr Ala Arg Phe Gln Ser Gln Thr Thr Leu Lys Gln Lys Thr 1 5 10 <210> SEQ ID NO 2504 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB5*0101 <400> SEQUENCE: 2504 Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 1 5 10 <210> SEQ ID NO 2505 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2505 Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2506 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV ENV 313 substitution peptide <400> SEQUENCE: 2506 Phe Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2507 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV ENV 313 substitution peptide <400> SEQUENCE: 2507 Ile Pro Ile Pro Ser Ser Trp Ala Ile 1 5 <210> SEQ ID NO 2508 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2508 Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 2509 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV POL 541 substitution peptide <400> SEQUENCE: 2509 Phe Pro His Cys Leu Ala Phe Ala Leu 1 5 <210> SEQ ID NO 2510 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV POL 541 substitution peptide <400> SEQUENCE: 2510 Phe Pro His Cys Leu Ala Phe Ser Leu 1 5 <210> SEQ ID NO 2511 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV POL 541 substitution peptide <400> SEQUENCE: 2511 Phe Pro Phe Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 2512 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV POL 541 substitution peptide <400> SEQUENCE: 2512 Phe Pro His Cys Leu Ala Phe Ser Ile 1 5 <210> SEQ ID NO 2513 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV POL 541 substitution peptide <400> SEQUENCE: 2513 Phe Pro His Cys Leu Ala Phe Ser Ala 1 5 <210> SEQ ID NO 2514 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis C virus <400> SEQUENCE: 2514 Leu Pro Gly Cys Ser Phe Ser Ile Phe 1 5 <210> SEQ ID NO 2515 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HCV Core 168 substitution peptide <400> SEQUENCE: 2515 Phe Pro Gly Cys Ser Phe Ser Ile Phe 1 5 <210> SEQ ID NO 2516 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 2516 Val Pro Ile Ser His Leu Tyr Ile Leu 1 5 <210> SEQ ID NO 2517 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic MAGE2 170 substitution peptide <400> SEQUENCE: 2517 Phe Pro Ile Ser His Leu Tyr Ile Leu 1 5 <210> SEQ ID NO 2518 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 2518 Met Pro Lys Ala Gly Leu Leu Ile Ile 1 5 <210> SEQ ID NO 2519 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic MAGE3 196 substitution peptide <400> SEQUENCE: 2519 Phe Pro Lys Ala Gly Leu Leu Ile Ile 1 5 <210> SEQ ID NO 2520 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic MAGE3 196 substitution peptide <400> SEQUENCE: 2520 Met Pro Phe Ala Gly Leu Leu Ile Ile 1 5 <210> SEQ ID NO 2521 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2521 Phe Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2522 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2522 Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 2523 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2523 Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 2524 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2524 Trp Leu Ser Leu Leu Val Pro Phe Val 1 5 <210> SEQ ID NO 2525 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2525 Tyr Met Asp Asp Val Val Leu Gly Ala 1 5 <210> SEQ ID NO 2526 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2526 Gly Leu Ser Arg Tyr Val Ala Arg Leu 1 5 <210> SEQ ID NO 2527 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2527 Phe Leu Leu Ser Leu Gly Ile His Leu 1 5 <210> SEQ ID NO 2528 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2528 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 10 <210> SEQ ID NO 2529 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2529 Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 <210> SEQ ID NO 2530 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2530 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 2531 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2531 Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2532 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2532 Asn Val Ser Ile Pro Trp Thr His Lys 1 5 <210> SEQ ID NO 2533 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2533 Leu Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 10 <210> SEQ ID NO 2534 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2534 Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 10 <210> SEQ ID NO 2535 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2535 Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 2536 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2536 Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 <210> SEQ ID NO 2537 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2537 Phe Pro His Cys Leu Ala Phe Ser Tyr Met 1 5 10 <210> SEQ ID NO 2538 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2538 Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 <210> SEQ ID NO 2539 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2539 Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2540 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2540 His Pro Ala Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 2541 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2541 Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 10 <210> SEQ ID NO 2542 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2542 Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 2543 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2543 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 2544 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2544 Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 2545 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2545 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 2546 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2546 Arg Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 10 <210> SEQ ID NO 2547 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2547 Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 2548 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2548 Ser Trp Trp Thr Ser Leu Asn Phe Leu 1 5 <210> SEQ ID NO 2549 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2549 Glu Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 10 <210> SEQ ID NO 2550 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2550 Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 <210> SEQ ID NO 2551 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2551 Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 2552 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2552 Ser Trp Pro Lys Phe Ala Val Pro Asn Leu 1 5 10 <210> SEQ ID NO 2553 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2553 Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 2554 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2554 Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 2555 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2555 Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 10 15 <210> SEQ ID NO 2556 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2556 Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys 1 5 10 15 <210> SEQ ID NO 2557 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2557 Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser 1 5 10 15 <210> SEQ ID NO 2558 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2558 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala Asp 1 5 10 15 <210> SEQ ID NO 2559 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2559 Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro 1 5 10 15 Asn Ala Pro Ile 20 <210> SEQ ID NO 2560 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2560 Arg His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 15 <210> SEQ ID NO 2561 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2561 Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val 1 5 10 15 <210> SEQ ID NO 2562 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2562 Leu His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 10 15 <210> SEQ ID NO 2563 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2563 Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val 1 5 10 15 <210> SEQ ID NO 2564 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2564 Lys Gln Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 15 <210> SEQ ID NO 2565 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2565 Ala Ala Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val Pro 1 5 10 15 <210> SEQ ID NO 2566 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2566 Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu 1 5 10 15 Met Thr Leu Ala 20 <210> SEQ ID NO 2567 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2567 Leu Cys Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 15 <210> SEQ ID NO 2568 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2568 Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg Gly Asn 1 5 10 15 <210> SEQ ID NO 2569 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2569 Val Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Lys Leu Ile 1 5 10 15 <210> SEQ ID NO 2570 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2570 Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 15 <210> SEQ ID NO 2571 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2571 Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His 1 5 10 15 <210> SEQ ID NO 2572 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Clostridium tetani <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)...(14) <223> OTHER INFORMATION: tetanus toxoid positions 830-843 <400> SEQUENCE: 2572 Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 1 5 10 <210> SEQ ID NO 2573 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Plasmodium falciparum <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)...(21) <223> OTHER INFORMATION: CS protein positions 378-398 <400> SEQUENCE: 2573 Asp Ile Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe 1 5 10 15 Asn Val Val Asn Ser 20 <210> SEQ ID NO 2574 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Streptococcus sp. <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)...(16) <223> OTHER INFORMATION: 18kd protein position 116 <400> SEQUENCE: 2574 Gly Ala Val Asp Ser Ile Leu Gly Gly Val Ala Thr Tyr Gly Ala Ala 1 5 10 15 <210> SEQ ID NO 2575 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic pan-DR binding epitope peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 3 <223> OTHER INFORMATION: Xaa=cyclohexylalanine, phenylalanine, or tyrosine <400> SEQUENCE: 2575 Ala Lys Xaa Val Trp Ala Asn Thr Leu Lys Ala Ala Ala 1 5 10 <210> SEQ ID NO 2576 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Synthetic A3CON1 peptide <400> SEQUENCE: 2576 Lys Val Phe Pro Tyr Ala Leu Ile Asn Lys 1 5 10 <210> SEQ ID NO 2577 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: T7Y analogue of HBVc 141-151 <400> SEQUENCE: 2577 Ser Thr Leu Pro Glu Thr Tyr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2578 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic DR7 preferred motif <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 1 <223> OTHER INFORMATION: Xaa=Met, Phe, Leu, Ile, Val, Trp or Tyr <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Ile, Val, Met, Ser, Ala, Cys, Thr, Pro, Leu <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 8 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 9 <223> OTHER INFORMATION: Xaa=Ile or Val <400> SEQUENCE: 2578 Xaa Met Trp Ala Xaa Xaa Met Xaa Xaa 1 5 <210> SEQ ID NO 2579 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic DR7 deleterious motif <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 1 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 3 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 7 <223> OTHER INFORMATION: Xaa=Gly, Arg or Asp <400> SEQUENCE: 2579 Xaa Cys Xaa Gly Xaa Xaa Xaa Asn Gly 1 5

1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 2579 <210> SEQ ID NO 1 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1 Ala Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 10 <210> SEQ ID NO 2 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2 Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 <210> SEQ ID NO 3 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 3 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 4 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 4 Ala Ser Phe Cys Gly Ser Pro Tyr 1 5 <210> SEQ ID NO 5 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 5 Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp 1 5 10 <210> SEQ ID NO 6 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 6 Ala Ser Lys Leu Cys Leu Gly Trp 1 5 <210> SEQ ID NO 7 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 7 Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp 1 5 10 <210> SEQ ID NO 8 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 8 Ala Ser Pro Leu His Val Ala Trp 1 5 <210> SEQ ID NO 9 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 9 Cys Ile Pro Ile Pro Ser Ser Trp 1 5 <210> SEQ ID NO 10 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 10 Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 10 <210> SEQ ID NO 11 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 11 Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 12 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 12 Cys Leu Arg Arg Phe Ile Ile Phe 1 5 <210> SEQ ID NO 13 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 13 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 1 5 10 <210> SEQ ID NO 14 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 14 Cys Ser Val Val Arg Arg Ala Phe 1 5 <210> SEQ ID NO 15 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 15 Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp 1 5 10 <210> SEQ ID NO 16 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 16 Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 17 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 17 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 18 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 18 Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 19 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 19 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 10 <210> SEQ ID NO 20 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 20 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 21 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 21 Glu Ser Arg Leu Val Val Asp Phe 1 5 <210> SEQ ID NO 22 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 22 Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 10 <210> SEQ ID NO 23 <211> LENGTH: 9

<212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 23 Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 24 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 24 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 25 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 25 Phe Leu Leu Val Leu Leu Asp Tyr 1 5 <210> SEQ ID NO 26 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 26 Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 <210> SEQ ID NO 27 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 27 Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 10 <210> SEQ ID NO 28 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 28 Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 10 <210> SEQ ID NO 29 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 29 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 10 <210> SEQ ID NO 30 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 30 Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 <210> SEQ ID NO 31 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 31 Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 32 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 32 Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 10 <210> SEQ ID NO 33 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 33 Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 <210> SEQ ID NO 34 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 34 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 10 <210> SEQ ID NO 35 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 35 His Leu Asn Pro Asn Lys Thr Lys Arg Trp 1 5 10 <210> SEQ ID NO 36 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 36 His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 37 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 37 His Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 10 <210> SEQ ID NO 38 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 38 His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 10 <210> SEQ ID NO 39 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 39 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 40 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 40 Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 41 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 41 Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 <210> SEQ ID NO 42 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 42 Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 43 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 43 Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 10 <210> SEQ ID NO 44 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 44 Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 10 <210> SEQ ID NO 45 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 45 Lys Leu Cys Leu Gly Trp Leu Trp 1 5

<210> SEQ ID NO 46 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 46 Lys Leu Ile Met Pro Ala Arg Phe 1 5 <210> SEQ ID NO 47 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 47 Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 48 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 48 Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 <210> SEQ ID NO 49 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 49 Lys Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 50 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 50 Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 <210> SEQ ID NO 51 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 51 Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 52 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 52 Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 53 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 53 Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 <210> SEQ ID NO 54 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 54 Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 55 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 55 Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 56 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 56 Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 <210> SEQ ID NO 57 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 57 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 10 <210> SEQ ID NO 58 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 58 Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 59 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 59 Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 60 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 60 Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 61 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 61 Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 62 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 62 Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 63 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 63 Leu Leu Val Pro Phe Val Gln Trp 1 5 <210> SEQ ID NO 64 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 64 Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 65 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 65 Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 10 <210> SEQ ID NO 66 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 66 Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 67 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 67 Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 <210> SEQ ID NO 68 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 68 Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5

<210> SEQ ID NO 69 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 69 Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 70 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 70 Leu Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 10 <210> SEQ ID NO 71 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 71 Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 72 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 72 Leu Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 73 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 73 Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 <210> SEQ ID NO 74 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 74 Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 10 <210> SEQ ID NO 75 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 75 Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 76 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 76 Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 10 <210> SEQ ID NO 77 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 77 Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 78 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 78 Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 10 <210> SEQ ID NO 79 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 79 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 80 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 80 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 81 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 81 Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 10 <210> SEQ ID NO 82 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 82 Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 83 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 83 Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 84 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 84 Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 85 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 85 Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 86 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 86 Met Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 87 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 87 Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 10 <210> SEQ ID NO 88 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 88 Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp 1 5 10 <210> SEQ ID NO 89 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 89 Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 90 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 90 Asn Leu Asn Val Ser Ile Pro Trp 1 5 <210> SEQ ID NO 91 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 91

Asn Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 10 <210> SEQ ID NO 92 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 92 Asn Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 93 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 93 Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 <210> SEQ ID NO 94 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 94 Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 95 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 95 Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 <210> SEQ ID NO 96 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 96 Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 97 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 97 Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 10 <210> SEQ ID NO 98 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 98 Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 99 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 99 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 100 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 100 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 101 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 101 Pro Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 102 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 102 Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 103 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 103 Pro Val Asn Arg Pro Ile Asp Trp 1 5 <210> SEQ ID NO 104 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 104 Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 10 <210> SEQ ID NO 105 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 105 Arg Ile Val Gly Leu Leu Gly Phe 1 5 <210> SEQ ID NO 106 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 106 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 10 <210> SEQ ID NO 107 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 107 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 10 <210> SEQ ID NO 108 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 108 Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 109 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 109 Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 110 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 110 Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 <210> SEQ ID NO 111 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 111 Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 112 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 112 Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 113 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 113 Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 <210> SEQ ID NO 114 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 114 Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 <210> SEQ ID NO 115 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 115 Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 116 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 116 Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 117 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 117 Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 10 <210> SEQ ID NO 118 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 118 Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 119 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 119 Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 120 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 120 Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 121 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 121 Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 122 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 122 Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 123 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 123 Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 <210> SEQ ID NO 124 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 124 Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 125 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 125 Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 126 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 126 Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 127 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 127 Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 128 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 128 Thr Val Gln Ala Ser Lys Leu Cys Leu Gly Trp 1 5 10 <210> SEQ ID NO 129 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 129 Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 130 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 130 Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 131 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 131 Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 10 <210> SEQ ID NO 132 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 132 Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 133 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 133 Trp Ile Leu Arg Gly Thr Ser Phe 1 5 <210> SEQ ID NO 134 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 134 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 10 <210> SEQ ID NO 135 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 135 Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 <210> SEQ ID NO 136 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 136 Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 137 <211> LENGTH: 10 <212> TYPE: PRT

<213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 137 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 <210> SEQ ID NO 138 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 138 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 139 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 139 Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 140 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 140 Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 10 <210> SEQ ID NO 141 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 141 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 10 <210> SEQ ID NO 142 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 142 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 143 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 143 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 144 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 144 Trp Thr His Lys Val Gly Asn Phe 1 5 <210> SEQ ID NO 145 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 145 Tyr Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 10 <210> SEQ ID NO 146 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 146 Tyr Leu Val Ser Phe Gly Val Trp 1 5 <210> SEQ ID NO 147 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 147 Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 <210> SEQ ID NO 148 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 148 Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 <210> SEQ ID NO 149 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 149 Ala Ala Cys Phe Ala Arg Ser Arg Ser Gly Ala 1 5 10 <210> SEQ ID NO 150 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 150 Ala Ala Met Pro His Leu Leu Val 1 5 <210> SEQ ID NO 151 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 151 Ala Ala Asn Trp Ile Leu Arg Gly Thr 1 5 <210> SEQ ID NO 152 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 152 Ala Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala 1 5 10 <210> SEQ ID NO 153 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 153 Ala Ile Cys Ser Val Val Arg Arg Ala 1 5 <210> SEQ ID NO 154 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 154 Ala Ile Leu Cys Trp Gly Glu Leu 1 5 <210> SEQ ID NO 155 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 155 Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 156 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 156 Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 157 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 157 Ala Met Gln Trp Asn Ser Thr Thr 1 5 <210> SEQ ID NO 158 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 158 Ala Met Ser Thr Thr Asp Leu Glu Ala 1 5 <210> SEQ ID NO 159 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 159 Ala Thr Pro Thr Gly Trp Gly Leu 1 5 <210> SEQ ID NO 160

<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 160 Ala Thr Pro Thr Gly Trp Gly Leu Ala 1 5 <210> SEQ ID NO 161 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 161 Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 10 <210> SEQ ID NO 162 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 162 Ala Val Pro Asn Leu Gln Ser Leu 1 5 <210> SEQ ID NO 163 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 163 Ala Val Pro Asn Leu Gln Ser Leu Thr 1 5 <210> SEQ ID NO 164 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 164 Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu 1 5 10 <210> SEQ ID NO 165 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 165 Cys Ala Ala Asn Trp Ile Leu Arg Gly Thr 1 5 10 <210> SEQ ID NO 166 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 166 Cys Ala Phe Ser Ser Ala Gly Pro Cys Ala 1 5 10 <210> SEQ ID NO 167 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 167 Cys Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 10 <210> SEQ ID NO 168 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 168 Cys Ala Leu Arg Phe Thr Ser Ala 1 5 <210> SEQ ID NO 169 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 169 Cys Ile Pro Ile Pro Ser Ser Trp Ala 1 5 <210> SEQ ID NO 170 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 170 Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala 1 5 10 <210> SEQ ID NO 171 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 171 Cys Leu Ala Phe Ser Tyr Met Asp Asp Val 1 5 10 <210> SEQ ID NO 172 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 172 Cys Leu Ala Phe Ser Tyr Met Asp Asp Val Val 1 5 10 <210> SEQ ID NO 173 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 173 Cys Leu Gly Trp Leu Trp Gly Met 1 5 <210> SEQ ID NO 174 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 174 Cys Leu Gly Trp Leu Trp Gly Met Asp Ile 1 5 10 <210> SEQ ID NO 175 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 175 Cys Leu Ile Phe Leu Leu Val Leu 1 5 <210> SEQ ID NO 176 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 176 Cys Leu Ile Phe Leu Leu Val Leu Leu 1 5 <210> SEQ ID NO 177 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 177 Cys Leu Arg Arg Phe Ile Ile Phe Leu 1 5 <210> SEQ ID NO 178 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 178 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile 1 5 10 <210> SEQ ID NO 179 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 179 Cys Leu Thr Phe Gly Arg Glu Thr 1 5 <210> SEQ ID NO 180 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 180 Cys Leu Thr Phe Gly Arg Glu Thr Val 1 5 <210> SEQ ID NO 181 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 181 Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala 1 5 10 <210> SEQ ID NO 182 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 182 Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5

<210> SEQ ID NO 183 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 183 Asp Ala Thr Pro Thr Gly Trp Gly Leu Ala 1 5 10 <210> SEQ ID NO 184 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 184 Asp Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 10 <210> SEQ ID NO 185 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 185 Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala 1 5 10 <210> SEQ ID NO 186 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 186 Asp Leu Leu Asp Thr Ala Ser Ala 1 5 <210> SEQ ID NO 187 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 187 Asp Leu Leu Asp Thr Ala Ser Ala Leu 1 5 <210> SEQ ID NO 188 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 188 Asp Leu Asn Leu Gly Asn Leu Asn Val 1 5 <210> SEQ ID NO 189 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 189 Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 10 <210> SEQ ID NO 190 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 190 Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala 1 5 10 <210> SEQ ID NO 191 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 191 Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 <210> SEQ ID NO 192 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 192 Asp Val Leu Cys Leu Arg Pro Val 1 5 <210> SEQ ID NO 193 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 193 Asp Val Leu Cys Leu Arg Pro Val Gly Ala 1 5 10 <210> SEQ ID NO 194 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 194 Asp Val Val Leu Gly Ala Lys Ser Val 1 5 <210> SEQ ID NO 195 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 195 Glu Ala Gly Pro Leu Glu Glu Glu Leu 1 5 <210> SEQ ID NO 196 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 196 Glu Leu Gly Glu Glu Ile Arg Leu 1 5 <210> SEQ ID NO 197 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 197 Glu Leu Leu Ala Ala Cys Phe Ala 1 5 <210> SEQ ID NO 198 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 198 Glu Thr Val Leu Glu Tyr Leu Val 1 5 <210> SEQ ID NO 199 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 199 Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 <210> SEQ ID NO 200 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 200 Phe Ala Arg Ser Arg Ser Gly Ala 1 5 <210> SEQ ID NO 201 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 201 Phe Ala Ser Pro Leu His Val Ala 1 5 <210> SEQ ID NO 202 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 202 Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 <210> SEQ ID NO 203 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 203 Phe Ala Val Pro Asn Leu Gln Ser Leu Thr 1 5 10 <210> SEQ ID NO 204 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 204 Phe Ile Ile Phe Leu Phe Ile Leu 1 5 <210> SEQ ID NO 205 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 205 Phe Ile Ile Phe Leu Phe Ile Leu Leu

1 5 <210> SEQ ID NO 206 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 206 Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 1 5 10 <210> SEQ ID NO 207 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 207 Phe Ile Leu Leu Leu Cys Leu Ile 1 5 <210> SEQ ID NO 208 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 208 Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 209 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 209 Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 210 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 210 Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 <210> SEQ ID NO 211 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 211 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 10 <210> SEQ ID NO 212 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 212 Phe Leu Gly Pro Leu Leu Val Leu 1 5 <210> SEQ ID NO 213 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 213 Phe Leu Gly Pro Leu Leu Val Leu Gln Ala 1 5 10 <210> SEQ ID NO 214 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 214 Phe Leu Leu Ala Gln Phe Thr Ser Ala 1 5 <210> SEQ ID NO 215 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 215 Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 10 <210> SEQ ID NO 216 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 216 Phe Leu Leu Ser Leu Gly Ile His Leu 1 5 <210> SEQ ID NO 217 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 217 Phe Leu Leu Thr Arg Ile Leu Thr 1 5 <210> SEQ ID NO 218 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 218 Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 219 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 219 Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 220 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 220 Phe Leu Val Asp Lys Asn Pro His Asn Thr 1 5 10 <210> SEQ ID NO 221 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 221 Phe Thr Phe Ser Pro Thr Tyr Lys Ala 1 5 <210> SEQ ID NO 222 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 222 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 10 <210> SEQ ID NO 223 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 223 Phe Thr Gly Leu Tyr Ser Ser Thr 1 5 <210> SEQ ID NO 224 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 224 Phe Thr Gly Leu Tyr Ser Ser Thr Val 1 5 <210> SEQ ID NO 225 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 225 Phe Thr Gln Cys Gly Tyr Pro Ala 1 5 <210> SEQ ID NO 226 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 226 Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 <210> SEQ ID NO 227 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 227 Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met 1 5 10 <210> SEQ ID NO 228 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 228

Phe Thr Ser Ala Ile Cys Ser Val 1 5 <210> SEQ ID NO 229 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 229 Phe Thr Ser Ala Ile Cys Ser Val Val 1 5 <210> SEQ ID NO 230 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 230 Phe Val Gly Leu Ser Pro Thr Val 1 5 <210> SEQ ID NO 231 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 231 Phe Val Gly Leu Ser Pro Thr Val Trp Leu 1 5 10 <210> SEQ ID NO 232 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 232 Phe Val Leu Gly Gly Cys Arg His Lys Leu 1 5 10 <210> SEQ ID NO 233 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 233 Phe Val Leu Gly Gly Cys Arg His Lys Leu Val 1 5 10 <210> SEQ ID NO 234 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 234 Phe Val Gln Trp Phe Val Gly Leu 1 5 <210> SEQ ID NO 235 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 235 Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr 1 5 10 <210> SEQ ID NO 236 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 236 Phe Val Tyr Val Pro Ser Ala Leu 1 5 <210> SEQ ID NO 237 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 237 Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala 1 5 10 <210> SEQ ID NO 238 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 238 Gly Ala His Leu Ser Leu Arg Gly Leu 1 5 <210> SEQ ID NO 239 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 239 Gly Ala His Leu Ser Leu Arg Gly Leu Pro Val 1 5 10 <210> SEQ ID NO 240 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 240 Gly Ala Lys Ser Val Gln His Leu 1 5 <210> SEQ ID NO 241 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 241 Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu 1 5 10 <210> SEQ ID NO 242 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 242 Gly Ile His Leu Asn Pro Asn Lys Thr 1 5 <210> SEQ ID NO 243 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 243 Gly Ile Leu Tyr Lys Arg Glu Thr 1 5 <210> SEQ ID NO 244 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 244 Gly Ile Leu Tyr Lys Arg Glu Thr Thr 1 5 <210> SEQ ID NO 245 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 245 Gly Leu Cys Gln Val Phe Ala Asp Ala 1 5 <210> SEQ ID NO 246 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 246 Gly Leu Cys Gln Val Phe Ala Asp Ala Thr 1 5 10 <210> SEQ ID NO 247 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 247 Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr 1 5 10 <210> SEQ ID NO 248 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 248 Gly Leu Leu Gly Trp Ser Pro Gln Ala 1 5 <210> SEQ ID NO 249 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 249 Gly Leu Pro Val Cys Ala Phe Ser Ser Ala 1 5 10 <210> SEQ ID NO 250 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 250 Gly Leu Ser Pro Phe Leu Leu Ala 1 5 <210> SEQ ID NO 251 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 251 Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe Thr 1 5 10 <210> SEQ ID NO 252 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 252 Gly Leu Ser Pro Thr Val Trp Leu 1 5 <210> SEQ ID NO 253 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 253 Gly Leu Ser Pro Thr Val Trp Leu Ser Val 1 5 10 <210> SEQ ID NO 254 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 254 Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 10 <210> SEQ ID NO 255 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 255 Gly Met Leu Pro Val Cys Pro Leu 1 5 <210> SEQ ID NO 256 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 256 Gly Thr Asp Asn Ser Val Val Leu 1 5 <210> SEQ ID NO 257 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 257 Gly Thr Asn Leu Ser Val Pro Asn Pro Leu 1 5 10 <210> SEQ ID NO 258 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 258 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala 1 5 10 <210> SEQ ID NO 259 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 259 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 10 <210> SEQ ID NO 260 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 260 Gly Val Gly Leu Ser Pro Phe Leu 1 5 <210> SEQ ID NO 261 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 261 Gly Val Gly Leu Ser Pro Phe Leu Leu 1 5 <210> SEQ ID NO 262 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 262 Gly Val Gly Leu Ser Pro Phe Leu Leu Ala 1 5 10 <210> SEQ ID NO 263 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 263 Gly Val Trp Ile Arg Thr Pro Pro Ala 1 5 <210> SEQ ID NO 264 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 264 His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr 1 5 10 <210> SEQ ID NO 265 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 265 His Leu Leu Val Gly Ser Ser Gly Leu 1 5 <210> SEQ ID NO 266 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 266 His Leu Ser Leu Arg Gly Leu Pro Val 1 5 <210> SEQ ID NO 267 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 267 His Leu Ser Leu Arg Gly Leu Pro Val Cys Ala 1 5 10 <210> SEQ ID NO 268 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 268 His Leu Tyr Ser His Pro Ile Ile 1 5 <210> SEQ ID NO 269 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 269 His Leu Tyr Ser His Pro Ile Ile Leu 1 5 <210> SEQ ID NO 270 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 270 His Thr Ala Glu Leu Leu Ala Ala 1 5 <210> SEQ ID NO 271 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 271 His Thr Ala Glu Leu Leu Ala Ala Cys Phe Ala 1 5 10 <210> SEQ ID NO 272 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 272 His Thr Ala Leu Arg Gln Ala Ile 1 5 <210> SEQ ID NO 273 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 273 His Thr Ala Leu Arg Gln Ala Ile Leu 1 5 <210> SEQ ID NO 274 <211> LENGTH: 8

<212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 274 His Thr Leu Trp Lys Ala Gly Ile 1 5 <210> SEQ ID NO 275 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 275 His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 <210> SEQ ID NO 276 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 276 Ile Ile Phe Leu Phe Ile Leu Leu 1 5 <210> SEQ ID NO 277 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 277 Ile Ile Phe Leu Phe Ile Leu Leu Leu 1 5 <210> SEQ ID NO 278 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 278 Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 10 <210> SEQ ID NO 279 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 279 Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 280 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 280 Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 281 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 281 Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 282 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 282 Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 <210> SEQ ID NO 283 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 283 Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 <210> SEQ ID NO 284 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 284 Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 285 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 285 Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 10 <210> SEQ ID NO 286 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 286 Ile Leu Arg Gly Thr Ser Phe Val 1 5 <210> SEQ ID NO 287 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 287 Ile Leu Arg Gly Thr Ser Phe Val Tyr Val 1 5 10 <210> SEQ ID NO 288 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 288 Ile Leu Ser Thr Leu Pro Glu Thr 1 5 <210> SEQ ID NO 289 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 289 Ile Leu Ser Thr Leu Pro Glu Thr Thr 1 5 <210> SEQ ID NO 290 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 290 Ile Leu Ser Thr Leu Pro Glu Thr Thr Val 1 5 10 <210> SEQ ID NO 291 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 291 Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val 1 5 10 <210> SEQ ID NO 292 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 292 Ile Leu Thr Ile Pro Gln Ser Leu 1 5 <210> SEQ ID NO 293 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 293 Ile Leu Tyr Lys Arg Glu Thr Thr 1 5 <210> SEQ ID NO 294 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 294 Ile Val Gly Leu Leu Gly Phe Ala 1 5 <210> SEQ ID NO 295 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 295 Ile Val Gly Leu Leu Gly Phe Ala Ala 1 5 <210> SEQ ID NO 296 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 296 Lys Ala Gly Ile Leu Tyr Lys Arg Glu Thr 1 5 10

<210> SEQ ID NO 297 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 297 Lys Ala Gly Ile Leu Tyr Lys Arg Glu Thr Thr 1 5 10 <210> SEQ ID NO 298 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 298 Lys Ile Pro Met Gly Val Gly Leu 1 5 <210> SEQ ID NO 299 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 299 Lys Leu Cys Leu Gly Trp Leu Trp Gly Met 1 5 10 <210> SEQ ID NO 300 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 300 Lys Leu His Leu Tyr Ser His Pro Ile 1 5 <210> SEQ ID NO 301 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 301 Lys Leu His Leu Tyr Ser His Pro Ile Ile 1 5 10 <210> SEQ ID NO 302 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 302 Lys Leu His Leu Tyr Ser His Pro Ile Ile Leu 1 5 10 <210> SEQ ID NO 303 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 303 Lys Leu Pro Val Asn Arg Pro Ile 1 5 <210> SEQ ID NO 304 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 304 Lys Thr Lys Arg Trp Gly Tyr Ser Leu 1 5 <210> SEQ ID NO 305 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 305 Lys Val Cys Gln Arg Ile Val Gly Leu 1 5 <210> SEQ ID NO 306 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 306 Lys Val Cys Gln Arg Ile Val Gly Leu Leu 1 5 10 <210> SEQ ID NO 307 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 307 Lys Val Gly Asn Phe Thr Gly Leu 1 5 <210> SEQ ID NO 308 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 308 Lys Val Leu His Lys Arg Thr Leu 1 5 <210> SEQ ID NO 309 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 309 Lys Val Leu His Lys Arg Thr Leu Gly Leu 1 5 10 <210> SEQ ID NO 310 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 310 Leu Ala Phe Ser Tyr Met Asp Asp Val 1 5 <210> SEQ ID NO 311 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 311 Leu Ala Phe Ser Tyr Met Asp Asp Val Val 1 5 10 <210> SEQ ID NO 312 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 312 Leu Ala Phe Ser Tyr Met Asp Asp Val Val Leu 1 5 10 <210> SEQ ID NO 313 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 313 Leu Ala Gln Phe Thr Ser Ala Ile 1 5 <210> SEQ ID NO 314 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 314 Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val 1 5 10 <210> SEQ ID NO 315 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 315 Leu Ile Phe Leu Leu Val Leu Leu 1 5 <210> SEQ ID NO 316 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 316 Leu Leu Ala Gln Phe Thr Ser Ala 1 5 <210> SEQ ID NO 317 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 317 Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 <210> SEQ ID NO 318 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 318 Leu Leu Cys Leu Ile Phe Leu Leu 1 5 <210> SEQ ID NO 319 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 319 Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5

<210> SEQ ID NO 320 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 320 Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 1 5 10 <210> SEQ ID NO 321 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 321 Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu 1 5 10 <210> SEQ ID NO 322 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 322 Leu Leu Asp Thr Ala Ser Ala Leu 1 5 <210> SEQ ID NO 323 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 323 Leu Leu Asp Tyr Gln Gly Met Leu 1 5 <210> SEQ ID NO 324 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 324 Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 325 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 325 Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 <210> SEQ ID NO 326 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 326 Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu 1 5 10 <210> SEQ ID NO 327 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 327 Leu Leu Gly Phe Ala Ala Pro Phe Thr 1 5 <210> SEQ ID NO 328 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 328 Leu Leu Gly Trp Ser Pro Gln Ala 1 5 <210> SEQ ID NO 329 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 329 Leu Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile 1 5 10 <210> SEQ ID NO 330 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 330 Leu Leu Leu Cys Leu Ile Phe Leu 1 5 <210> SEQ ID NO 331 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 331 Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 <210> SEQ ID NO 332 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 332 Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 10 <210> SEQ ID NO 333 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 333 Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 1 5 10 <210> SEQ ID NO 334 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 334 Leu Leu Pro Ile Phe Phe Cys Leu 1 5 <210> SEQ ID NO 335 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 335 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 10 <210> SEQ ID NO 336 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 336 Leu Leu Ser Leu Gly Ile His Leu 1 5 <210> SEQ ID NO 337 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 337 Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 <210> SEQ ID NO 338 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 338 Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu 1 5 10 <210> SEQ ID NO 339 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 339 Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 340 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 340 Leu Leu Val Gly Ser Ser Gly Leu 1 5 <210> SEQ ID NO 341 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 341 Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 342 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 342

Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 10 <210> SEQ ID NO 343 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 343 Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 10 <210> SEQ ID NO 344 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 344 Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 10 <210> SEQ ID NO 345 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 345 Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 <210> SEQ ID NO 346 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 346 Leu Leu Trp Phe His Ile Ser Cys Leu 1 5 <210> SEQ ID NO 347 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 347 Leu Leu Trp Phe His Ile Ser Cys Leu Thr 1 5 10 <210> SEQ ID NO 348 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 348 Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 349 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 349 Leu Thr Phe Gly Arg Glu Thr Val 1 5 <210> SEQ ID NO 350 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 350 Leu Thr Phe Gly Arg Glu Thr Val Leu 1 5 <210> SEQ ID NO 351 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 351 Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 <210> SEQ ID NO 352 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 352 Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 <210> SEQ ID NO 353 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 353 Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 354 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 354 Leu Val Asp Lys Asn Pro His Asn Thr 1 5 <210> SEQ ID NO 355 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 355 Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 356 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 356 Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 10 <210> SEQ ID NO 357 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 357 Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 <210> SEQ ID NO 358 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 358 Leu Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 10 <210> SEQ ID NO 359 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 359 Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr 1 5 10 <210> SEQ ID NO 360 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 360 Leu Val Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 361 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 361 Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 10 <210> SEQ ID NO 362 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 362 Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 363 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 363 Leu Val Ser Phe Gly Val Trp Ile Arg Thr 1 5 10 <210> SEQ ID NO 364 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 364 Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 <210> SEQ ID NO 365 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 365 Asn Ala Pro Ile Leu Ser Thr Leu 1 5 <210> SEQ ID NO 366 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 366 Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr 1 5 10 <210> SEQ ID NO 367 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 367 Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 <210> SEQ ID NO 368 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 368 Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 10 <210> SEQ ID NO 369 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 369 Asn Leu Asn Val Ser Ile Pro Trp Thr 1 5 <210> SEQ ID NO 370 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 370 Asn Leu Gln Ser Leu Thr Asn Leu 1 5 <210> SEQ ID NO 371 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 371 Asn Leu Gln Ser Leu Thr Asn Leu Leu 1 5 <210> SEQ ID NO 372 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 372 Asn Leu Ser Val Pro Asn Pro Leu 1 5 <210> SEQ ID NO 373 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 373 Asn Leu Ser Trp Leu Ser Leu Asp Val 1 5 <210> SEQ ID NO 374 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 374 Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala 1 5 10 <210> SEQ ID NO 375 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 375 Asn Val Ser Ile Pro Trp Thr His Lys Val 1 5 10 <210> SEQ ID NO 376 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 376 Pro Ala Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 377 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 377 Pro Ala Ala Met Pro His Leu Leu Val 1 5 <210> SEQ ID NO 378 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 378 Pro Ala Asp Asp Pro Ser Arg Gly Arg Leu 1 5 10 <210> SEQ ID NO 379 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 379 Pro Ala Gly Gly Ser Ser Ser Gly Thr 1 5 <210> SEQ ID NO 380 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 380 Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 1 5 10 <210> SEQ ID NO 381 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 381 Pro Ala Leu Met Pro Leu Tyr Ala 1 5 <210> SEQ ID NO 382 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 382 Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 10 <210> SEQ ID NO 383 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 383 Pro Ala Pro Cys Asn Phe Phe Thr 1 5 <210> SEQ ID NO 384 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 384 Pro Ala Pro Cys Asn Phe Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 385 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 385 Pro Ala Arg Asp Val Leu Cys Leu 1 5 <210> SEQ ID NO 386 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 386 Pro Ala Arg Asp Val Leu Cys Leu Arg Pro Val 1 5 10 <210> SEQ ID NO 387 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 387 Pro Ala Arg Val Thr Gly Gly Val 1 5 <210> SEQ ID NO 388 <211> LENGTH: 10 <212> TYPE: PRT

<213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 388 Pro Ala Arg Val Thr Gly Gly Val Phe Leu 1 5 10 <210> SEQ ID NO 389 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 389 Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val 1 5 10 <210> SEQ ID NO 390 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 390 Pro Ala Tyr Arg Pro Pro Asn Ala 1 5 <210> SEQ ID NO 391 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 391 Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 10 <210> SEQ ID NO 392 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 392 Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 1 5 10 <210> SEQ ID NO 393 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 393 Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 10 <210> SEQ ID NO 394 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 394 Pro Ile Asp Trp Lys Val Cys Gln Arg Ile Val 1 5 10 <210> SEQ ID NO 395 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 395 Pro Ile Phe Phe Cys Leu Trp Val 1 5 <210> SEQ ID NO 396 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 396 Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 10 <210> SEQ ID NO 397 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 397 Pro Ile His Thr Ala Glu Leu Leu 1 5 <210> SEQ ID NO 398 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 398 Pro Ile His Thr Ala Glu Leu Leu Ala 1 5 <210> SEQ ID NO 399 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 399 Pro Ile His Thr Ala Glu Leu Leu Ala Ala 1 5 10 <210> SEQ ID NO 400 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 400 Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 401 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 401 Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 402 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 402 Pro Ile Leu Ser Thr Leu Pro Glu Thr 1 5 <210> SEQ ID NO 403 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 403 Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr 1 5 10 <210> SEQ ID NO 404 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 404 Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val 1 5 10 <210> SEQ ID NO 405 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 405 Pro Ile Pro Ser Ser Trp Ala Phe Ala 1 5 <210> SEQ ID NO 406 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 406 Pro Leu Glu Glu Glu Leu Pro Arg Leu 1 5 <210> SEQ ID NO 407 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 407 Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala 1 5 10 <210> SEQ ID NO 408 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 408 Pro Leu Gly Phe Phe Pro Asp His Gln Leu 1 5 10 <210> SEQ ID NO 409 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 409 Pro Leu His Pro Ala Ala Met Pro His Leu 1 5 10 <210> SEQ ID NO 410 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 410 Pro Leu His Pro Ala Ala Met Pro His Leu Leu 1 5 10 <210> SEQ ID NO 411

<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 411 Pro Leu Leu Pro Ile Phe Phe Cys Leu 1 5 <210> SEQ ID NO 412 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 412 Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 10 <210> SEQ ID NO 413 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 413 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 10 <210> SEQ ID NO 414 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 414 Pro Leu Pro Ile His Thr Ala Glu Leu 1 5 <210> SEQ ID NO 415 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 415 Pro Leu Pro Ile His Thr Ala Glu Leu Leu 1 5 10 <210> SEQ ID NO 416 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 416 Pro Leu Pro Ile His Thr Ala Glu Leu Leu Ala 1 5 10 <210> SEQ ID NO 417 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 417 Pro Leu Ser Tyr Gln His Phe Arg Lys Leu 1 5 10 <210> SEQ ID NO 418 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 418 Pro Leu Ser Tyr Gln His Phe Arg Lys Leu Leu 1 5 10 <210> SEQ ID NO 419 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 419 Pro Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 10 <210> SEQ ID NO 420 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 420 Pro Met Gly Val Gly Leu Ser Pro Phe Leu 1 5 10 <210> SEQ ID NO 421 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 421 Pro Met Gly Val Gly Leu Ser Pro Phe Leu Leu 1 5 10 <210> SEQ ID NO 422 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 422 Pro Thr Gly Trp Gly Leu Ala Ile 1 5 <210> SEQ ID NO 423 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 423 Pro Thr Ser Asn His Ser Pro Thr 1 5 <210> SEQ ID NO 424 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 424 Pro Thr Thr Gly Arg Thr Ser Leu 1 5 <210> SEQ ID NO 425 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 425 Pro Thr Thr Gly Arg Thr Ser Leu Tyr Ala 1 5 10 <210> SEQ ID NO 426 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 426 Pro Thr Val Gln Ala Ser Lys Leu 1 5 <210> SEQ ID NO 427 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 427 Pro Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 10 <210> SEQ ID NO 428 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 428 Pro Thr Val Trp Leu Ser Val Ile 1 5 <210> SEQ ID NO 429 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 429 Pro Thr Val Trp Leu Ser Val Ile Trp Met 1 5 10 <210> SEQ ID NO 430 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 430 Pro Val Cys Ala Phe Ser Ser Ala 1 5 <210> SEQ ID NO 431 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 431 Pro Val Asn Arg Pro Ile Asp Trp Lys Val 1 5 10 <210> SEQ ID NO 432 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 432 Gln Ala Phe Thr Phe Ser Pro Thr 1 5 <210> SEQ ID NO 433 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 433 Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala 1 5 10

<210> SEQ ID NO 434 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 434 Gln Ala Gly Phe Phe Leu Leu Thr 1 5 <210> SEQ ID NO 435 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 435 Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile 1 5 10 <210> SEQ ID NO 436 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 436 Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu 1 5 10 <210> SEQ ID NO 437 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 437 Gln Ala Ile Leu Cys Trp Gly Glu Leu 1 5 <210> SEQ ID NO 438 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 438 Gln Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 10 <210> SEQ ID NO 439 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 439 Gln Ala Met Gln Trp Asn Ser Thr 1 5 <210> SEQ ID NO 440 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 440 Gln Ala Met Gln Trp Asn Ser Thr Thr 1 5 <210> SEQ ID NO 441 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 441 Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu 1 5 10 <210> SEQ ID NO 442 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 442 Gln Leu Asp Pro Ala Arg Asp Val 1 5 <210> SEQ ID NO 443 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 443 Gln Leu Asp Pro Ala Arg Asp Val Leu 1 5 <210> SEQ ID NO 444 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 444 Gln Leu Asp Pro Ala Arg Asp Val Leu Cys Leu 1 5 10 <210> SEQ ID NO 445 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 445 Gln Leu Leu Trp Phe His Ile Ser Cys Leu 1 5 10 <210> SEQ ID NO 446 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 446 Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr 1 5 10 <210> SEQ ID NO 447 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 447 Gln Val Phe Ala Asp Ala Thr Pro Thr 1 5 <210> SEQ ID NO 448 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 448 Arg Ala Phe Pro His Cys Leu Ala 1 5 <210> SEQ ID NO 449 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 449 Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 <210> SEQ ID NO 450 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 450 Arg Ile Val Gly Leu Leu Gly Phe Ala 1 5 <210> SEQ ID NO 451 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 451 Arg Ile Val Gly Leu Leu Gly Phe Ala Ala 1 5 10 <210> SEQ ID NO 452 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 452 Arg Leu Lys Leu Ile Met Pro Ala 1 5 <210> SEQ ID NO 453 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 453 Arg Thr Pro Ala Arg Val Thr Gly Gly Val 1 5 10 <210> SEQ ID NO 454 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 454 Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala 1 5 10 <210> SEQ ID NO 455 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 455 Arg Val Ala Glu Asp Leu Asn Leu 1 5 <210> SEQ ID NO 456 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 456 Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu

1 5 10 <210> SEQ ID NO 457 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 457 Arg Val His Phe Ala Ser Pro Leu 1 5 <210> SEQ ID NO 458 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 458 Arg Val His Phe Ala Ser Pro Leu His Val 1 5 10 <210> SEQ ID NO 459 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 459 Arg Val His Phe Ala Ser Pro Leu His Val Ala 1 5 10 <210> SEQ ID NO 460 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 460 Arg Val Thr Gly Gly Val Phe Leu 1 5 <210> SEQ ID NO 461 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 461 Arg Val Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 462 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 462 Ser Ala Gly Pro Cys Ala Leu Arg Phe Thr 1 5 10 <210> SEQ ID NO 463 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 463 Ser Ala Ile Cys Ser Val Val Arg Arg Ala 1 5 10 <210> SEQ ID NO 464 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 464 Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 <210> SEQ ID NO 465 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 465 Ser Ile Pro Trp Thr His Lys Val 1 5 <210> SEQ ID NO 466 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 466 Ser Leu Asp Ser Trp Trp Thr Ser Leu 1 5 <210> SEQ ID NO 467 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 467 Ser Leu Gly Ile His Leu Asn Pro Asn Lys Thr 1 5 10 <210> SEQ ID NO 468 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 468 Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 <210> SEQ ID NO 469 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 469 Ser Leu Asn Phe Met Gly Tyr Val 1 5 <210> SEQ ID NO 470 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 470 Ser Leu Asn Phe Met Gly Tyr Val Ile 1 5 <210> SEQ ID NO 471 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 471 Ser Leu Arg Gly Leu Pro Val Cys Ala 1 5 <210> SEQ ID NO 472 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 472 Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 10 <210> SEQ ID NO 473 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 473 Ser Thr Gly Pro Cys Lys Thr Cys Thr 1 5 <210> SEQ ID NO 474 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 474 Ser Thr Leu Pro Glu Thr Thr Val 1 5 <210> SEQ ID NO 475 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 475 Ser Thr Leu Pro Glu Thr Thr Val Val 1 5 <210> SEQ ID NO 476 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 476 Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr 1 5 10 <210> SEQ ID NO 477 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 477 Ser Val Gln His Leu Glu Ser Leu 1 5 <210> SEQ ID NO 478 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 478 Ser Val Arg Phe Ser Trp Leu Ser Leu 1 5 <210> SEQ ID NO 479 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 479

Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 1 5 10 <210> SEQ ID NO 480 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 480 Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val 1 5 10 <210> SEQ ID NO 481 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 481 Ser Val Val Leu Ser Arg Lys Tyr Thr 1 5 <210> SEQ ID NO 482 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 482 Ser Val Val Arg Arg Ala Phe Pro His Cys Leu 1 5 10 <210> SEQ ID NO 483 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 483 Thr Ala Glu Leu Leu Ala Ala Cys Phe Ala 1 5 10 <210> SEQ ID NO 484 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 484 Thr Ala Leu Arg Gln Ala Ile Leu 1 5 <210> SEQ ID NO 485 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 485 Thr Ala Ser Ala Leu Tyr Arg Glu Ala 1 5 <210> SEQ ID NO 486 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 486 Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 <210> SEQ ID NO 487 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 487 Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr 1 5 10 <210> SEQ ID NO 488 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 488 Thr Leu Pro Glu Thr Thr Val Val 1 5 <210> SEQ ID NO 489 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 489 Thr Leu Trp Lys Ala Gly Ile Leu 1 5 <210> SEQ ID NO 490 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 490 Thr Thr Gly Arg Thr Ser Leu Tyr Ala 1 5 <210> SEQ ID NO 491 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 491 Thr Thr Ser Thr Gly Pro Cys Lys Thr 1 5 <210> SEQ ID NO 492 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 492 Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr 1 5 10 <210> SEQ ID NO 493 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 493 Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 494 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 494 Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 <210> SEQ ID NO 495 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 495 Thr Val Trp Leu Ser Val Ile Trp Met 1 5 <210> SEQ ID NO 496 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 496 Val Ala Glu Asp Leu Asn Leu Gly Asn Leu 1 5 10 <210> SEQ ID NO 497 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 497 Val Leu Cys Leu Arg Pro Val Gly Ala 1 5 <210> SEQ ID NO 498 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 498 Val Leu Gly Ala Lys Ser Val Gln His Leu 1 5 10 <210> SEQ ID NO 499 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 499 Val Leu Gly Gly Cys Arg His Lys Leu 1 5 <210> SEQ ID NO 500 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 500 Val Leu Gly Gly Cys Arg His Lys Leu Val 1 5 10 <210> SEQ ID NO 501 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 501 Val Leu His Lys Arg Thr Leu Gly Leu 1 5 <210> SEQ ID NO 502 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 502 Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 503 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 503 Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 <210> SEQ ID NO 504 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 504 Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 505 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 505 Val Leu Gln Ala Gly Phe Phe Leu 1 5 <210> SEQ ID NO 506 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 506 Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 <210> SEQ ID NO 507 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 507 Val Leu Gln Ala Gly Phe Phe Leu Leu Thr 1 5 10 <210> SEQ ID NO 508 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 508 Val Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 509 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 509 Val Val Leu Gly Ala Lys Ser Val 1 5 <210> SEQ ID NO 510 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 510 Val Val Leu Gly Ala Lys Ser Val Gln His Leu 1 5 10 <210> SEQ ID NO 511 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 511 Val Val Leu Ser Arg Lys Tyr Thr 1 5 <210> SEQ ID NO 512 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 512 Val Val Arg Arg Ala Phe Pro His Cys Leu 1 5 10 <210> SEQ ID NO 513 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 513 Val Val Arg Arg Ala Phe Pro His Cys Leu Ala 1 5 10 <210> SEQ ID NO 514 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 514 Trp Ile Leu Arg Gly Thr Ser Phe Val 1 5 <210> SEQ ID NO 515 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 515 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val 1 5 10 <210> SEQ ID NO 516 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 516 Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 10 <210> SEQ ID NO 517 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 517 Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu 1 5 10 <210> SEQ ID NO 518 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 518 Trp Leu Ser Leu Asp Val Ser Ala 1 5 <210> SEQ ID NO 519 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 519 Trp Leu Ser Leu Asp Val Ser Ala Ala 1 5 <210> SEQ ID NO 520 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 520 Trp Leu Ser Leu Leu Val Pro Phe Val 1 5 <210> SEQ ID NO 521 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 521 Trp Met Cys Leu Arg Arg Phe Ile 1 5 <210> SEQ ID NO 522 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 522 Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 <210> SEQ ID NO 523 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 523 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu 1 5 10 <210> SEQ ID NO 524 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 524 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 10 <210> SEQ ID NO 525 <211> LENGTH: 9

<212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 525 Trp Thr His Lys Val Gly Asn Phe Thr 1 5 <210> SEQ ID NO 526 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 526 Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu 1 5 10 <210> SEQ ID NO 527 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 527 Tyr Leu His Thr Leu Trp Lys Ala 1 5 <210> SEQ ID NO 528 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 528 Tyr Leu His Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 529 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 529 Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 10 <210> SEQ ID NO 530 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 530 Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 <210> SEQ ID NO 531 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 531 Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 532 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 532 Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 1 5 10 <210> SEQ ID NO 533 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 533 Tyr Met Asp Asp Val Val Leu Gly Ala 1 5 <210> SEQ ID NO 534 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 534 Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 535 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 535 Tyr Thr Ser Phe Pro Trp Leu Leu Gly Cys Ala 1 5 10 <210> SEQ ID NO 536 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 536 Tyr Val Pro Ser Ala Leu Asn Pro Ala 1 5 <210> SEQ ID NO 537 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 537 Ala Ala Cys Phe Ala Arg Ser Arg 1 5 <210> SEQ ID NO 538 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 538 Ala Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 539 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 539 Ala Leu Asn Pro Ala Asp Asp Pro Ser Arg 1 5 10 <210> SEQ ID NO 540 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 540 Ala Leu Arg Phe Thr Ser Ala Arg 1 5 <210> SEQ ID NO 541 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 541 Ala Ser Pro Leu His Val Ala Trp Arg 1 5 <210> SEQ ID NO 542 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 542 Ala Ser Thr Asn Arg Gln Ser Gly Arg 1 5 <210> SEQ ID NO 543 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 543 Cys Ala Ala Asn Trp Ile Leu Arg 1 5 <210> SEQ ID NO 544 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 544 Cys Ala Leu Arg Phe Thr Ser Ala Arg 1 5 <210> SEQ ID NO 545 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 545 Cys Leu Arg Pro Val Gly Ala Glu Ser Arg 1 5 10 <210> SEQ ID NO 546 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 546 Cys Ser Pro His His Thr Ala Leu Arg 1 5 <210> SEQ ID NO 547 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 547 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 10

<210> SEQ ID NO 548 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 548 Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 <210> SEQ ID NO 549 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 549 Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg 1 5 10 <210> SEQ ID NO 550 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 550 Glu Leu Leu Ala Ala Cys Phe Ala Arg 1 5 <210> SEQ ID NO 551 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 551 Glu Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 10 <210> SEQ ID NO 552 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 552 Glu Thr Thr Val Val Arg Arg Arg 1 5 <210> SEQ ID NO 553 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 553 Glu Thr Thr Val Val Arg Arg Arg Gly Arg 1 5 10 <210> SEQ ID NO 554 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 554 Phe Ala Ser Pro Leu His Val Ala Trp Arg 1 5 10 <210> SEQ ID NO 555 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 555 Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg 1 5 10 <210> SEQ ID NO 556 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 556 Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 557 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 557 Phe Thr Ser Ala Ile Cys Ser Val Val Arg 1 5 10 <210> SEQ ID NO 558 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 558 Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 10 <210> SEQ ID NO 559 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 559 Phe Val Leu Gly Gly Cys Arg His Lys 1 5 <210> SEQ ID NO 560 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 560 Gly Ile His Leu Asn Pro Asn Lys 1 5 <210> SEQ ID NO 561 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 561 Gly Ile His Leu Asn Pro Asn Lys Thr Lys 1 5 10 <210> SEQ ID NO 562 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 562 Gly Ile His Leu Asn Pro Asn Lys Thr Lys Arg 1 5 10 <210> SEQ ID NO 563 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 563 Gly Met Asp Ile Asp Pro Tyr Lys 1 5 <210> SEQ ID NO 564 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 564 Gly Thr Asp Asn Ser Val Val Leu Ser Arg 1 5 10 <210> SEQ ID NO 565 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 565 Gly Thr Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 <210> SEQ ID NO 566 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 566 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg 1 5 10 <210> SEQ ID NO 567 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 567 His Ile Ser Cys Leu Thr Phe Gly Arg 1 5 <210> SEQ ID NO 568 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 568 His Leu Asn Pro Asn Lys Thr Lys 1 5 <210> SEQ ID NO 569 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 569 His Leu Asn Pro Asn Lys Thr Lys Arg 1 5 <210> SEQ ID NO 570 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 570 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10

<210> SEQ ID NO 571 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 571 Ile Ser Cys Leu Thr Phe Gly Arg 1 5 <210> SEQ ID NO 572 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 572 Lys Ala Gly Ile Leu Tyr Lys Arg 1 5 <210> SEQ ID NO 573 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 573 Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys 1 5 10 <210> SEQ ID NO 574 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 574 Lys Val Phe Val Leu Gly Gly Cys Arg 1 5 <210> SEQ ID NO 575 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 575 Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 <210> SEQ ID NO 576 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 576 Leu Leu Ala Ala Cys Phe Ala Arg 1 5 <210> SEQ ID NO 577 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 577 Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 10 <210> SEQ ID NO 578 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 578 Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 10 <210> SEQ ID NO 579 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 579 Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg 1 5 10 <210> SEQ ID NO 580 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 580 Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 10 <210> SEQ ID NO 581 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 581 Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 582 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 582 Leu Ser Tyr Gln His Phe Arg Lys 1 5 <210> SEQ ID NO 583 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 583 Leu Thr Val Asn Glu Lys Arg Arg 1 5 <210> SEQ ID NO 584 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 584 Leu Val Ser Phe Gly Val Trp Ile Arg 1 5 <210> SEQ ID NO 585 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 585 Leu Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 10 <210> SEQ ID NO 586 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 586 Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 10 <210> SEQ ID NO 587 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 587 Asn Leu Glu Asp Pro Ala Ser Arg 1 5 <210> SEQ ID NO 588 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 588 Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys 1 5 10 <210> SEQ ID NO 589 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 589 Asn Ser Val Val Leu Ser Arg Lys 1 5 <210> SEQ ID NO 590 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 590 Asn Val Ser Ile Pro Trp Thr His Lys 1 5 <210> SEQ ID NO 591 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 591 Pro Ala Asp Asp Pro Ser Arg Gly Arg 1 5 <210> SEQ ID NO 592 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 592 Pro Ala Arg Asp Val Leu Cys Leu Arg 1 5 <210> SEQ ID NO 593 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 593

Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 1 5 10 <210> SEQ ID NO 594 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 594 Pro Ile Asp Trp Lys Val Cys Gln Arg 1 5 <210> SEQ ID NO 595 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 595 Pro Ile Ile Leu Gly Phe Arg Lys 1 5 <210> SEQ ID NO 596 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 596 Pro Leu Glu Glu Glu Leu Pro Arg 1 5 <210> SEQ ID NO 597 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 597 Pro Leu Ser Tyr Gln His Phe Arg 1 5 <210> SEQ ID NO 598 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 598 Pro Leu Ser Tyr Gln His Phe Arg Lys 1 5 <210> SEQ ID NO 599 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 599 Pro Leu Thr Val Asn Glu Lys Arg 1 5 <210> SEQ ID NO 600 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 600 Pro Leu Thr Val Asn Glu Lys Arg Arg 1 5 <210> SEQ ID NO 601 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 601 Pro Val Gly Ala Glu Ser Arg Gly Arg 1 5 <210> SEQ ID NO 602 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 602 Pro Val Asn Arg Pro Ile Asp Trp Lys 1 5 <210> SEQ ID NO 603 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 603 Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 10 <210> SEQ ID NO 604 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 604 Gln Ala Gly Phe Phe Leu Leu Thr Arg 1 5 <210> SEQ ID NO 605 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 605 Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg 1 5 10 <210> SEQ ID NO 606 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 606 Gln Ser Ser Gly Ile Leu Ser Arg 1 5 <210> SEQ ID NO 607 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 607 Arg Leu Lys Leu Ile Met Pro Ala Arg 1 5 <210> SEQ ID NO 608 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 608 Arg Leu Lys Val Phe Val Leu Gly Gly Cys Arg 1 5 10 <210> SEQ ID NO 609 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 609 Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 10 <210> SEQ ID NO 610 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 610 Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro Arg 1 5 10 <210> SEQ ID NO 611 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 611 Arg Ser Gln Ser Pro Arg Arg Arg 1 5 <210> SEQ ID NO 612 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 612 Arg Ser Gln Ser Pro Arg Arg Arg Arg 1 5 <210> SEQ ID NO 613 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 613 Arg Thr Pro Ser Pro Arg Arg Arg 1 5 <210> SEQ ID NO 614 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 614 Arg Thr Pro Ser Pro Arg Arg Arg Arg 1 5 <210> SEQ ID NO 615 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 615 Arg Val Thr Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 616 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 616 Ser Ala Gly Pro Cys Ala Leu Arg 1 5 <210> SEQ ID NO 617 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 617 Ser Ala Ile Cys Ser Val Val Arg 1 5 <210> SEQ ID NO 618 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 618 Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 619 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 619 Ser Ala Leu Asn Pro Ala Asp Asp Pro Ser Arg 1 5 10 <210> SEQ ID NO 620 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 620 Ser Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 10 <210> SEQ ID NO 621 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 621 Ser Ser Ala Gly Pro Cys Ala Leu Arg 1 5 <210> SEQ ID NO 622 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 622 Ser Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 623 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 623 Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 624 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 624 Ser Thr Asn Arg Gln Ser Gly Arg 1 5 <210> SEQ ID NO 625 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 625 Ser Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 10 <210> SEQ ID NO 626 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 626 Thr Ala Glu Leu Leu Ala Ala Cys Phe Ala Arg 1 5 10 <210> SEQ ID NO 627 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 627 Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 <210> SEQ ID NO 628 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 628 Thr Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 629 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 629 Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg 1 5 10 <210> SEQ ID NO 630 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 630 Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 631 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 631 Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg 1 5 10 <210> SEQ ID NO 632 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 632 Thr Ser Ala Ile Cys Ser Val Val Arg 1 5 <210> SEQ ID NO 633 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 633 Thr Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 10 <210> SEQ ID NO 634 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 634 Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 <210> SEQ ID NO 635 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 635 Thr Thr Ser Thr Gly Pro Cys Lys 1 5 <210> SEQ ID NO 636 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 636 Thr Thr Val Val Arg Arg Arg Gly Arg 1 5 <210> SEQ ID NO 637 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 637 Thr Val Val Arg Arg Arg Gly Arg 1 5 <210> SEQ ID NO 638 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 638 Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg 1 5 10 <210> SEQ ID NO 639 <211> LENGTH: 8 <212> TYPE: PRT

<213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 639 Val Leu Gly Gly Cys Arg His Lys 1 5 <210> SEQ ID NO 640 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 640 Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg 1 5 10 <210> SEQ ID NO 641 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 641 Val Ser Phe Gly Val Trp Ile Arg 1 5 <210> SEQ ID NO 642 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 642 Val Ser Ile Pro Trp Thr His Lys 1 5 <210> SEQ ID NO 643 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 643 Val Thr Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 644 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 644 Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 <210> SEQ ID NO 645 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 645 Val Val Arg Arg Arg Gly Arg Ser Pro Arg 1 5 10 <210> SEQ ID NO 646 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 646 Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg 1 5 10 <210> SEQ ID NO 647 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 647 Trp Ile Arg Thr Pro Pro Ala Tyr Arg 1 5 <210> SEQ ID NO 648 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 648 Trp Leu Gln Phe Arg Asn Ser Lys 1 5 <210> SEQ ID NO 649 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 649 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr Lys 1 5 10 <210> SEQ ID NO 650 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 650 Tyr Leu Pro Leu Asp Lys Gly Ile Lys 1 5 <210> SEQ ID NO 651 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 651 Tyr Leu Val Ser Phe Gly Val Trp Ile Arg 1 5 10 <210> SEQ ID NO 652 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 652 Tyr Met Asp Asp Val Val Leu Gly Ala Lys 1 5 10 <210> SEQ ID NO 653 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 653 Tyr Ser His Pro Ile Ile Leu Gly Phe Arg 1 5 10 <210> SEQ ID NO 654 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 654 Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys 1 5 10 <210> SEQ ID NO 655 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 655 Ala Phe Pro His Cys Leu Ala Phe 1 5 <210> SEQ ID NO 656 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 656 Ala Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 10 <210> SEQ ID NO 657 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 657 Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met 1 5 10 <210> SEQ ID NO 658 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 658 Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 10 <210> SEQ ID NO 659 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 659 Ala Phe Ser Tyr Met Asp Asp Val Val Leu 1 5 10 <210> SEQ ID NO 660 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 660 Ala Phe Thr Phe Ser Pro Thr Tyr 1 5 <210> SEQ ID NO 661 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 661 Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 10 <210> SEQ ID NO 662

<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 662 Ala Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 10 <210> SEQ ID NO 663 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 663 Ala Ile Leu Cys Trp Gly Glu Leu 1 5 <210> SEQ ID NO 664 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 664 Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 665 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 665 Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 666 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 666 Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 <210> SEQ ID NO 667 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 667 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 668 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 668 Ala Thr Pro Thr Gly Trp Gly Leu 1 5 <210> SEQ ID NO 669 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 669 Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 10 <210> SEQ ID NO 670 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 670 Ala Val Pro Asn Leu Gln Ser Leu 1 5 <210> SEQ ID NO 671 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 671 Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu 1 5 10 <210> SEQ ID NO 672 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 672 Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 <210> SEQ ID NO 673 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 673 Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 1 5 10 <210> SEQ ID NO 674 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 674 Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile 1 5 10 <210> SEQ ID NO 675 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 675 Cys Ile Pro Ile Pro Ser Ser Trp 1 5 <210> SEQ ID NO 676 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 676 Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 10 <210> SEQ ID NO 677 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 677 Cys Leu Gly Trp Leu Trp Gly Met 1 5 <210> SEQ ID NO 678 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 678 Cys Leu Gly Trp Leu Trp Gly Met Asp Ile 1 5 10 <210> SEQ ID NO 679 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 679 Cys Leu Ile Phe Leu Leu Val Leu 1 5 <210> SEQ ID NO 680 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 680 Cys Leu Ile Phe Leu Leu Val Leu Leu 1 5 <210> SEQ ID NO 681 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 681 Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 682 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 682 Cys Leu Arg Arg Phe Ile Ile Phe 1 5 <210> SEQ ID NO 683 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 683 Cys Leu Arg Arg Phe Ile Ile Phe Leu 1 5 <210> SEQ ID NO 684 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 684 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 1 5 10

<210> SEQ ID NO 685 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 685 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile 1 5 10 <210> SEQ ID NO 686 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 686 Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp 1 5 10 <210> SEQ ID NO 687 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 687 Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 688 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 688 Asp Leu Leu Asp Thr Ala Ser Ala Leu 1 5 <210> SEQ ID NO 689 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 689 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 690 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 690 Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 10 <210> SEQ ID NO 691 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 691 Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 <210> SEQ ID NO 692 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 692 Asp Trp Lys Val Cys Gln Arg Ile 1 5 <210> SEQ ID NO 693 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 693 Asp Trp Lys Val Cys Gln Arg Ile Val Gly Leu 1 5 10 <210> SEQ ID NO 694 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 694 Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu 1 5 10 <210> SEQ ID NO 695 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 695 Glu Leu Gly Glu Glu Ile Arg Leu 1 5 <210> SEQ ID NO 696 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 696 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 10 <210> SEQ ID NO 697 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 697 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 698 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 698 Glu Tyr Leu Val Ser Phe Gly Val Trp 1 5 <210> SEQ ID NO 699 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 699 Glu Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 10 <210> SEQ ID NO 700 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 700 Phe Phe Cys Leu Trp Val Tyr Ile 1 5 <210> SEQ ID NO 701 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 701 Phe Phe Leu Leu Thr Arg Ile Leu 1 5 <210> SEQ ID NO 702 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 702 Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 10 <210> SEQ ID NO 703 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 703 Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe 1 5 10 <210> SEQ ID NO 704 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 704 Phe Ile Ile Phe Leu Phe Ile Leu 1 5 <210> SEQ ID NO 705 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 705 Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 <210> SEQ ID NO 706 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 706 Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 1 5 10 <210> SEQ ID NO 707 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 707 Phe Ile Leu Leu Leu Cys Leu Ile

1 5 <210> SEQ ID NO 708 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 708 Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 709 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 709 Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 710 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 710 Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 711 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 711 Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 <210> SEQ ID NO 712 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 712 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 10 <210> SEQ ID NO 713 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 713 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 714 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 714 Phe Leu Gly Pro Leu Leu Val Leu 1 5 <210> SEQ ID NO 715 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 715 Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 10 <210> SEQ ID NO 716 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 716 Phe Leu Leu Ser Leu Gly Ile His Leu 1 5 <210> SEQ ID NO 717 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 717 Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 718 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 718 Phe Leu Leu Val Leu Leu Asp Tyr 1 5 <210> SEQ ID NO 719 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 719 Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 720 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 720 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 10 <210> SEQ ID NO 721 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 721 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 10 <210> SEQ ID NO 722 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 722 Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 <210> SEQ ID NO 723 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 723 Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met 1 5 10 <210> SEQ ID NO 724 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 724 Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 <210> SEQ ID NO 725 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 725 Phe Val Gly Leu Ser Pro Thr Val Trp Leu 1 5 10 <210> SEQ ID NO 726 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 726 Phe Val Leu Gly Gly Cys Arg His Lys Leu 1 5 10 <210> SEQ ID NO 727 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 727 Phe Val Gln Trp Phe Val Gly Leu 1 5 <210> SEQ ID NO 728 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 728 Phe Val Tyr Val Pro Ser Ala Leu 1 5 <210> SEQ ID NO 729 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 729 Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 10 <210> SEQ ID NO 730 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 730

Gly Phe Phe Leu Leu Thr Arg Ile 1 5 <210> SEQ ID NO 731 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 731 Gly Phe Phe Leu Leu Thr Arg Ile Leu 1 5 <210> SEQ ID NO 732 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 732 Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 10 <210> SEQ ID NO 733 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 733 Gly Phe Phe Pro Asp His Gln Leu 1 5 <210> SEQ ID NO 734 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 734 Gly Phe Leu Gly Pro Leu Leu Val Leu 1 5 <210> SEQ ID NO 735 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 735 Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu 1 5 10 <210> SEQ ID NO 736 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 736 Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 737 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 737 Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 10 <210> SEQ ID NO 738 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 738 Gly Leu Ser Pro Thr Val Trp Leu 1 5 <210> SEQ ID NO 739 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 739 Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 10 <210> SEQ ID NO 740 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 740 Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 <210> SEQ ID NO 741 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 741 Gly Met Leu Pro Val Cys Pro Leu 1 5 <210> SEQ ID NO 742 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 742 Gly Thr Asp Asn Ser Val Val Leu 1 5 <210> SEQ ID NO 743 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 743 Gly Thr Asn Leu Ser Val Pro Asn Pro Leu 1 5 10 <210> SEQ ID NO 744 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 744 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 10 <210> SEQ ID NO 745 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 745 Gly Val Gly Leu Ser Pro Phe Leu 1 5 <210> SEQ ID NO 746 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 746 Gly Val Gly Leu Ser Pro Phe Leu Leu 1 5 <210> SEQ ID NO 747 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 747 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 10 <210> SEQ ID NO 748 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 748 Gly Trp Leu Trp Gly Met Asp Ile 1 5 <210> SEQ ID NO 749 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 749 Gly Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 10 <210> SEQ ID NO 750 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 750 Gly Trp Ser Pro Gln Ala Gln Gly Ile 1 5 <210> SEQ ID NO 751 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 751 Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu 1 5 10 <210> SEQ ID NO 752 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 752 Gly Tyr Pro Ala Leu Met Pro Leu 1 5 <210> SEQ ID NO 753 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 753 Gly Tyr Pro Ala Leu Met Pro Leu Tyr 1 5 <210> SEQ ID NO 754 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 754 Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 1 5 10 <210> SEQ ID NO 755 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 755 Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile 1 5 10 <210> SEQ ID NO 756 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 756 Gly Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 <210> SEQ ID NO 757 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 757 Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val Ile 1 5 10 <210> SEQ ID NO 758 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 758 His Phe Ala Ser Pro Leu His Val Ala Trp 1 5 10 <210> SEQ ID NO 759 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 759 His Phe Arg Lys Leu Leu Leu Leu 1 5 <210> SEQ ID NO 760 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 760 His Leu Leu Val Gly Ser Ser Gly Leu 1 5 <210> SEQ ID NO 761 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 761 His Leu Asn Pro Asn Lys Thr Lys Arg Trp 1 5 10 <210> SEQ ID NO 762 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 762 His Leu Tyr Ser His Pro Ile Ile 1 5 <210> SEQ ID NO 763 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 763 His Leu Tyr Ser His Pro Ile Ile Leu 1 5 <210> SEQ ID NO 764 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 764 His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 765 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 765 His Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 10 <210> SEQ ID NO 766 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 766 His Thr Ala Leu Arg Gln Ala Ile 1 5 <210> SEQ ID NO 767 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 767 His Thr Ala Leu Arg Gln Ala Ile Leu 1 5 <210> SEQ ID NO 768 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 768 His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 10 <210> SEQ ID NO 769 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 769 His Thr Leu Trp Lys Ala Gly Ile 1 5 <210> SEQ ID NO 770 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 770 His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 <210> SEQ ID NO 771 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 771 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 772 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 772 His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 773 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 773 Ile Phe Phe Cys Leu Trp Val Tyr 1 5 <210> SEQ ID NO 774 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 774 Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 <210> SEQ ID NO 775 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 775 Ile Phe Leu Phe Ile Leu Leu Leu 1 5 <210> SEQ ID NO 776 <211> LENGTH: 10

<212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 776 Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 10 <210> SEQ ID NO 777 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 777 Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 10 <210> SEQ ID NO 778 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 778 Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 <210> SEQ ID NO 779 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 779 Ile Ile Phe Leu Phe Ile Leu Leu 1 5 <210> SEQ ID NO 780 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 780 Ile Ile Phe Leu Phe Ile Leu Leu Leu 1 5 <210> SEQ ID NO 781 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 781 Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 10 <210> SEQ ID NO 782 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 782 Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 783 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 783 Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 784 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 784 Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 785 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 785 Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 <210> SEQ ID NO 786 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 786 Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 787 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 787 Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 <210> SEQ ID NO 788 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 788 Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 789 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 789 Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 <210> SEQ ID NO 790 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 790 Ile Leu Thr Ile Pro Gln Ser Leu 1 5 <210> SEQ ID NO 791 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 791 Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 792 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 792 Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 10 <210> SEQ ID NO 793 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 793 Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 10 <210> SEQ ID NO 794 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 794 Lys Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 10 <210> SEQ ID NO 795 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 795 Lys Ile Pro Met Gly Val Gly Leu 1 5 <210> SEQ ID NO 796 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 796 Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 10 <210> SEQ ID NO 797 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 797 Lys Leu Cys Leu Gly Trp Leu Trp 1 5 <210> SEQ ID NO 798 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 798 Lys Leu Cys Leu Gly Trp Leu Trp Gly Met 1 5 10

<210> SEQ ID NO 799 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 799 Lys Leu His Leu Tyr Ser His Pro Ile 1 5 <210> SEQ ID NO 800 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 800 Lys Leu His Leu Tyr Ser His Pro Ile Ile 1 5 10 <210> SEQ ID NO 801 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 801 Lys Leu His Leu Tyr Ser His Pro Ile Ile Leu 1 5 10 <210> SEQ ID NO 802 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 802 Lys Leu Ile Met Pro Ala Arg Phe 1 5 <210> SEQ ID NO 803 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 803 Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 804 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 804 Lys Leu Pro Val Asn Arg Pro Ile 1 5 <210> SEQ ID NO 805 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 805 Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 <210> SEQ ID NO 806 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 806 Lys Thr Lys Arg Trp Gly Tyr Ser Leu 1 5 <210> SEQ ID NO 807 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 807 Lys Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 808 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 808 Lys Val Cys Gln Arg Ile Val Gly Leu 1 5 <210> SEQ ID NO 809 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 809 Lys Val Cys Gln Arg Ile Val Gly Leu Leu 1 5 10 <210> SEQ ID NO 810 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 810 Lys Val Gly Asn Phe Thr Gly Leu 1 5 <210> SEQ ID NO 811 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 811 Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 <210> SEQ ID NO 812 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 812 Lys Val Leu His Lys Arg Thr Leu 1 5 <210> SEQ ID NO 813 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 813 Lys Val Leu His Lys Arg Thr Leu Gly Leu 1 5 10 <210> SEQ ID NO 814 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 814 Lys Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 <210> SEQ ID NO 815 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 815 Lys Tyr Thr Ser Phe Pro Trp Leu 1 5 <210> SEQ ID NO 816 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 816 Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 817 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 817 Leu Phe Ile Leu Leu Leu Cys Leu 1 5 <210> SEQ ID NO 818 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 818 Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 <210> SEQ ID NO 819 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 819 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 820 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 820 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 821 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 821 Leu Ile Phe Leu Leu Val Leu Leu 1 5

<210> SEQ ID NO 822 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 822 Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 823 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 823 Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 824 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 824 Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 <210> SEQ ID NO 825 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 825 Leu Leu Cys Leu Ile Phe Leu Leu 1 5 <210> SEQ ID NO 826 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 826 Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 1 5 10 <210> SEQ ID NO 827 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 827 Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu 1 5 10 <210> SEQ ID NO 828 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 828 Leu Leu Asp Thr Ala Ser Ala Leu 1 5 <210> SEQ ID NO 829 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 829 Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 <210> SEQ ID NO 830 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 830 Leu Leu Asp Tyr Gln Gly Met Leu 1 5 <210> SEQ ID NO 831 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 831 Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 832 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 832 Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 <210> SEQ ID NO 833 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 833 Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu 1 5 10 <210> SEQ ID NO 834 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 834 Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 835 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 835 Leu Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile 1 5 10 <210> SEQ ID NO 836 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 836 Leu Leu Leu Cys Leu Ile Phe Leu 1 5 <210> SEQ ID NO 837 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 837 Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 <210> SEQ ID NO 838 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 838 Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 1 5 10 <210> SEQ ID NO 839 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 839 Leu Leu Pro Ile Phe Phe Cys Leu 1 5 <210> SEQ ID NO 840 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 840 Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 <210> SEQ ID NO 841 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 841 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 10 <210> SEQ ID NO 842 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 842 Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 843 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 843 Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 844 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 844

Leu Leu Ser Leu Gly Ile His Leu 1 5 <210> SEQ ID NO 845 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 845 Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 846 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 846 Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 <210> SEQ ID NO 847 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 847 Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu 1 5 10 <210> SEQ ID NO 848 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 848 Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 849 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 849 Leu Leu Val Gly Ser Ser Gly Leu 1 5 <210> SEQ ID NO 850 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 850 Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 851 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 851 Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 10 <210> SEQ ID NO 852 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 852 Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 853 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 853 Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 854 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 854 Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 10 <210> SEQ ID NO 855 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 855 Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 10 <210> SEQ ID NO 856 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 856 Leu Leu Val Pro Phe Val Gln Trp 1 5 <210> SEQ ID NO 857 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 857 Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 858 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 858 Leu Leu Trp Phe His Ile Ser Cys Leu 1 5 <210> SEQ ID NO 859 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 859 Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 10 <210> SEQ ID NO 860 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 860 Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 861 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 861 Leu Thr Phe Gly Arg Glu Thr Val Leu 1 5 <210> SEQ ID NO 862 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 862 Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 10 <210> SEQ ID NO 863 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 863 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 864 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 864 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 865 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 865 Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 <210> SEQ ID NO 866 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 866 Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 10 <210> SEQ ID NO 867 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 867 Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 <210> SEQ ID NO 868 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 868 Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 869 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 869 Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 870 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 870 Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 10 <210> SEQ ID NO 871 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 871 Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 872 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 872 Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 <210> SEQ ID NO 873 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 873 Leu Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 10 <210> SEQ ID NO 874 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 874 Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 875 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 875 Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 10 <210> SEQ ID NO 876 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 876 Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 877 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 877 Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 878 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 878 Leu Trp Phe His Ile Ser Cys Leu 1 5 <210> SEQ ID NO 879 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 879 Leu Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 10 <210> SEQ ID NO 880 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 880 Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 <210> SEQ ID NO 881 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 881 Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 882 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 882 Leu Tyr Ser His Pro Ile Ile Leu 1 5 <210> SEQ ID NO 883 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 883 Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 884 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 884 Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 <210> SEQ ID NO 885 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 885 Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 886 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 886 Met Trp Tyr Trp Gly Pro Ser Leu 1 5 <210> SEQ ID NO 887 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 887 Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 <210> SEQ ID NO 888 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 888 Asn Phe Leu Leu Ser Leu Gly Ile 1 5 <210> SEQ ID NO 889 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 889 Asn Phe Leu Leu Ser Leu Gly Ile His Leu 1 5 10 <210> SEQ ID NO 890 <211> LENGTH: 9 <212> TYPE: PRT

<213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 890 Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 <210> SEQ ID NO 891 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 891 Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp 1 5 10 <210> SEQ ID NO 892 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 892 Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 893 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 893 Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 10 <210> SEQ ID NO 894 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 894 Asn Leu Asn Val Ser Ile Pro Trp 1 5 <210> SEQ ID NO 895 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 895 Asn Leu Gln Ser Leu Thr Asn Leu 1 5 <210> SEQ ID NO 896 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 896 Asn Leu Gln Ser Leu Thr Asn Leu Leu 1 5 <210> SEQ ID NO 897 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 897 Asn Leu Ser Val Pro Asn Pro Leu 1 5 <210> SEQ ID NO 898 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 898 Asn Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 10 <210> SEQ ID NO 899 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 899 Asn Trp Ile Leu Arg Gly Thr Ser Phe 1 5 <210> SEQ ID NO 900 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 900 Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 10 <210> SEQ ID NO 901 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 901 Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 10 <210> SEQ ID NO 902 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 902 Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 10 <210> SEQ ID NO 903 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 903 Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met 1 5 10 <210> SEQ ID NO 904 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 904 Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 <210> SEQ ID NO 905 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 905 Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 10 <210> SEQ ID NO 906 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 906 Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 <210> SEQ ID NO 907 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 907 Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 10 <210> SEQ ID NO 908 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 908 Pro Ile His Thr Ala Glu Leu Leu 1 5 <210> SEQ ID NO 909 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 909 Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 910 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 910 Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 911 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 911 Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 912 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 912 Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 <210> SEQ ID NO 913

<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 913 Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 914 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 914 Pro Leu Glu Glu Glu Leu Pro Arg Leu 1 5 <210> SEQ ID NO 915 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 915 Pro Leu Gly Phe Phe Pro Asp His Gln Leu 1 5 10 <210> SEQ ID NO 916 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 916 Pro Leu His Pro Ala Ala Met Pro His Leu 1 5 10 <210> SEQ ID NO 917 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 917 Pro Leu His Pro Ala Ala Met Pro His Leu Leu 1 5 10 <210> SEQ ID NO 918 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 918 Pro Leu Leu Pro Ile Phe Phe Cys Leu 1 5 <210> SEQ ID NO 919 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 919 Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 10 <210> SEQ ID NO 920 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 920 Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 921 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 921 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 922 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 922 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 1 5 10 <210> SEQ ID NO 923 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 923 Pro Leu Pro Ile His Thr Ala Glu Leu 1 5 <210> SEQ ID NO 924 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 924 Pro Leu Pro Ile His Thr Ala Glu Leu Leu 1 5 10 <210> SEQ ID NO 925 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 925 Pro Leu Ser Tyr Gln His Phe Arg Lys Leu 1 5 10 <210> SEQ ID NO 926 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 926 Pro Leu Ser Tyr Gln His Phe Arg Lys Leu Leu 1 5 10 <210> SEQ ID NO 927 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 927 Pro Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 10 <210> SEQ ID NO 928 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 928 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 929 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 929 Pro Met Gly Val Gly Leu Ser Pro Phe Leu 1 5 10 <210> SEQ ID NO 930 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 930 Pro Met Gly Val Gly Leu Ser Pro Phe Leu Leu 1 5 10 <210> SEQ ID NO 931 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 931 Pro Thr Gly Trp Gly Leu Ala Ile 1 5 <210> SEQ ID NO 932 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 932 Pro Thr Thr Gly Arg Thr Ser Leu 1 5 <210> SEQ ID NO 933 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 933 Pro Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 934 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 934 Pro Thr Val Gln Ala Ser Lys Leu 1 5 <210> SEQ ID NO 935 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 935 Pro Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 10

<210> SEQ ID NO 936 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 936 Pro Thr Val Trp Leu Ser Val Ile 1 5 <210> SEQ ID NO 937 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 937 Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 938 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 938 Pro Thr Val Trp Leu Ser Val Ile Trp Met 1 5 10 <210> SEQ ID NO 939 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 939 Pro Val Asn Arg Pro Ile Asp Trp 1 5 <210> SEQ ID NO 940 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 940 Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 10 <210> SEQ ID NO 941 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 941 Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 10 <210> SEQ ID NO 942 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 942 Pro Trp Thr His Lys Val Gly Asn Phe 1 5 <210> SEQ ID NO 943 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 943 Gln Leu Asp Pro Ala Arg Asp Val Leu 1 5 <210> SEQ ID NO 944 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 944 Gln Leu Asp Pro Ala Arg Asp Val Leu Cys Leu 1 5 10 <210> SEQ ID NO 945 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 945 Gln Leu Leu Trp Phe His Ile Ser Cys Leu 1 5 10 <210> SEQ ID NO 946 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 946 Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 10 <210> SEQ ID NO 947 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 947 Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 10 <210> SEQ ID NO 948 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 948 Arg Phe Ile Ile Phe Leu Phe Ile 1 5 <210> SEQ ID NO 949 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 949 Arg Phe Ile Ile Phe Leu Phe Ile Leu 1 5 <210> SEQ ID NO 950 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 950 Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 10 <210> SEQ ID NO 951 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 951 Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 1 5 10 <210> SEQ ID NO 952 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 952 Arg Phe Ser Trp Leu Ser Leu Leu 1 5 <210> SEQ ID NO 953 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 953 Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 10 <210> SEQ ID NO 954 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 954 Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 <210> SEQ ID NO 955 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 955 Arg Ile Val Gly Leu Leu Gly Phe 1 5 <210> SEQ ID NO 956 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 956 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 10 <210> SEQ ID NO 957 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 957 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 10 <210> SEQ ID NO 958 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 958 Arg Leu Val Val Asp Phe Ser Gln Phe

1 5 <210> SEQ ID NO 959 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 959 Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 960 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 960 Arg Val Ala Glu Asp Leu Asn Leu 1 5 <210> SEQ ID NO 961 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 961 Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu 1 5 10 <210> SEQ ID NO 962 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 962 Arg Val His Phe Ala Ser Pro Leu 1 5 <210> SEQ ID NO 963 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 963 Arg Val Thr Gly Gly Val Phe Leu 1 5 <210> SEQ ID NO 964 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 964 Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 965 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 965 Arg Trp Gly Tyr Ser Leu Asn Phe Met 1 5 <210> SEQ ID NO 966 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 966 Arg Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 10 <210> SEQ ID NO 967 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 967 Arg Trp Met Cys Leu Arg Arg Phe 1 5 <210> SEQ ID NO 968 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 968 Arg Trp Met Cys Leu Arg Arg Phe Ile 1 5 <210> SEQ ID NO 969 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 969 Arg Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 10 <210> SEQ ID NO 970 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 970 Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 971 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 971 Ser Phe Cys Gly Ser Pro Tyr Ser Trp 1 5 <210> SEQ ID NO 972 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 972 Ser Phe Leu Pro Ser Asp Phe Phe 1 5 <210> SEQ ID NO 973 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 973 Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 <210> SEQ ID NO 974 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 974 Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 <210> SEQ ID NO 975 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 975 Ser Leu Asp Ser Trp Trp Thr Ser Leu 1 5 <210> SEQ ID NO 976 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 976 Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 977 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 977 Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 978 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 978 Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 <210> SEQ ID NO 979 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 979 Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 <210> SEQ ID NO 980 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 980 Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 981 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 981

Ser Leu Asn Phe Met Gly Tyr Val Ile 1 5 <210> SEQ ID NO 982 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 982 Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 983 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 983 Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 10 <210> SEQ ID NO 984 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 984 Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 985 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 985 Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 986 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 986 Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 987 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 987 Ser Val Gln His Leu Glu Ser Leu 1 5 <210> SEQ ID NO 988 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 988 Ser Val Arg Phe Ser Trp Leu Ser Leu 1 5 <210> SEQ ID NO 989 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 989 Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 1 5 10 <210> SEQ ID NO 990 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 990 Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 991 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 991 Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 992 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 992 Ser Val Val Arg Arg Ala Phe Pro His Cys Leu 1 5 10 <210> SEQ ID NO 993 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 993 Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 <210> SEQ ID NO 994 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 994 Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 995 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 995 Ser Trp Pro Lys Phe Ala Val Pro Asn Leu 1 5 10 <210> SEQ ID NO 996 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 996 Ser Trp Trp Thr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 997 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 997 Ser Trp Trp Thr Ser Leu Asn Phe Leu 1 5 <210> SEQ ID NO 998 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 998 Ser Tyr Met Asp Asp Val Val Leu 1 5 <210> SEQ ID NO 999 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 999 Ser Tyr Gln His Phe Arg Lys Leu 1 5 <210> SEQ ID NO 1000 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1000 Ser Tyr Gln His Phe Arg Lys Leu Leu 1 5 <210> SEQ ID NO 1001 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1001 Ser Tyr Gln His Phe Arg Lys Leu Leu Leu 1 5 10 <210> SEQ ID NO 1002 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1002 Ser Tyr Gln His Phe Arg Lys Leu Leu Leu Leu 1 5 10 <210> SEQ ID NO 1003 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1003 Thr Phe Gly Arg Glu Thr Val Leu 1 5 <210> SEQ ID NO 1004 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 1004 Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 10 <210> SEQ ID NO 1005 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1005 Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu 1 5 10 <210> SEQ ID NO 1006 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1006 Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 <210> SEQ ID NO 1007 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1007 Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 10 <210> SEQ ID NO 1008 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1008 Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 <210> SEQ ID NO 1009 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1009 Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 1010 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1010 Thr Leu Trp Lys Ala Gly Ile Leu 1 5 <210> SEQ ID NO 1011 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1011 Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 1012 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1012 Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 1013 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1013 Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 1014 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1014 Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 1015 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1015 Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 <210> SEQ ID NO 1016 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1016 Thr Val Gln Ala Ser Lys Leu Cys Leu Gly Trp 1 5 10 <210> SEQ ID NO 1017 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1017 Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 1018 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1018 Thr Val Trp Leu Ser Val Ile Trp Met 1 5 <210> SEQ ID NO 1019 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1019 Val Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 10 <210> SEQ ID NO 1020 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1020 Val Phe Val Leu Gly Gly Cys Arg His Lys Leu 1 5 10 <210> SEQ ID NO 1021 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1021 Val Leu Gly Ala Lys Ser Val Gln His Leu 1 5 10 <210> SEQ ID NO 1022 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1022 Val Leu Gly Gly Cys Arg His Lys Leu 1 5 <210> SEQ ID NO 1023 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1023 Val Leu His Lys Arg Thr Leu Gly Leu 1 5 <210> SEQ ID NO 1024 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1024 Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 1025 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1025 Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 <210> SEQ ID NO 1026 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1026 Val Leu Gln Ala Gly Phe Phe Leu 1 5 <210> SEQ ID NO 1027 <211> LENGTH: 9

<212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1027 Val Leu Gln Ala Gly Phe Phe Leu Leu 1 5 <210> SEQ ID NO 1028 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1028 Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 1029 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1029 Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 10 <210> SEQ ID NO 1030 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1030 Val Val Leu Gly Ala Lys Ser Val Gln His Leu 1 5 10 <210> SEQ ID NO 1031 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1031 Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 1032 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1032 Val Val Arg Arg Ala Phe Pro His Cys Leu 1 5 10 <210> SEQ ID NO 1033 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1033 Val Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 <210> SEQ ID NO 1034 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1034 Val Trp Leu Ser Val Ile Trp Met 1 5 <210> SEQ ID NO 1035 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1035 Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 1036 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1036 Trp Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 10 <210> SEQ ID NO 1037 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1037 Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 1 5 10 <210> SEQ ID NO 1038 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1038 Trp Ile Leu Arg Gly Thr Ser Phe 1 5 <210> SEQ ID NO 1039 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1039 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 10 <210> SEQ ID NO 1040 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1040 Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 <210> SEQ ID NO 1041 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1041 Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 1042 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1042 Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 10 <210> SEQ ID NO 1043 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1043 Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu 1 5 10 <210> SEQ ID NO 1044 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1044 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 <210> SEQ ID NO 1045 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1045 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 1046 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1046 Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 1047 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1047 Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 10 <210> SEQ ID NO 1048 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1048 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 10 <210> SEQ ID NO 1049 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1049 Trp Met Cys Leu Arg Arg Phe Ile 1 5

<210> SEQ ID NO 1050 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1050 Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 <210> SEQ ID NO 1051 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1051 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 1052 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1052 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu 1 5 10 <210> SEQ ID NO 1053 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1053 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 10 <210> SEQ ID NO 1054 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1054 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 1055 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1055 Trp Thr His Lys Val Gly Asn Phe 1 5 <210> SEQ ID NO 1056 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1056 Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu 1 5 10 <210> SEQ ID NO 1057 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1057 Trp Trp Thr Ser Leu Asn Phe Leu 1 5 <210> SEQ ID NO 1058 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1058 Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 <210> SEQ ID NO 1059 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1059 Tyr Leu His Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 1060 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1060 Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 10 <210> SEQ ID NO 1061 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1061 Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 <210> SEQ ID NO 1062 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1062 Tyr Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 10 <210> SEQ ID NO 1063 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1063 Tyr Leu Val Ser Phe Gly Val Trp 1 5 <210> SEQ ID NO 1064 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1064 Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 1065 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1065 Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 1066 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1066 Ala Pro Cys Asn Phe Phe Thr Ser Ala 1 5 <210> SEQ ID NO 1067 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1067 Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 <210> SEQ ID NO 1068 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1068 Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala 1 5 10 <210> SEQ ID NO 1069 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1069 Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 10 <210> SEQ ID NO 1070 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1070 Cys Pro Gly Tyr Arg Trp Met Cys Leu 1 5 <210> SEQ ID NO 1071 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1071 Cys Pro Thr Val Gln Ala Ser Lys Leu 1 5 <210> SEQ ID NO 1072 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1072 Cys Pro Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 10

<210> SEQ ID NO 1073 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1073 Asp Pro Ala Arg Asp Val Leu Cys Leu 1 5 <210> SEQ ID NO 1074 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1074 Asp Pro Arg Val Arg Gly Leu Tyr 1 5 <210> SEQ ID NO 1075 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1075 Asp Pro Ser Arg Gly Arg Leu Gly Leu 1 5 <210> SEQ ID NO 1076 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1076 Asp Pro Tyr Lys Glu Phe Gly Ala 1 5 <210> SEQ ID NO 1077 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1077 Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 1 5 10 <210> SEQ ID NO 1078 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1078 Phe Pro Asp His Gln Leu Asp Pro Ala 1 5 <210> SEQ ID NO 1079 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1079 Phe Pro Asp His Gln Leu Asp Pro Ala Phe 1 5 10 <210> SEQ ID NO 1080 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1080 Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 1081 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1081 Phe Pro His Cys Leu Ala Phe Ser Tyr Met 1 5 10 <210> SEQ ID NO 1082 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1082 Phe Pro Trp Leu Leu Gly Cys Ala 1 5 <210> SEQ ID NO 1083 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1083 Phe Pro Trp Leu Leu Gly Cys Ala Ala 1 5 <210> SEQ ID NO 1084 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1084 Phe Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 10 <210> SEQ ID NO 1085 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1085 Gly Pro Cys Ala Leu Arg Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 1086 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1086 Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu 1 5 10 <210> SEQ ID NO 1087 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1087 Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala 1 5 10 <210> SEQ ID NO 1088 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1088 Gly Pro Leu Leu Val Leu Gln Ala 1 5 <210> SEQ ID NO 1089 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1089 Gly Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 10 <210> SEQ ID NO 1090 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1090 Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 1091 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1091 Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 10 <210> SEQ ID NO 1092 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1092 His Pro Ala Ala Met Pro His Leu 1 5 <210> SEQ ID NO 1093 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1093 His Pro Ala Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 1094 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1094 His Pro Ala Ala Met Pro His Leu Leu Val 1 5 10 <210> SEQ ID NO 1095 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1095

His Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 10 <210> SEQ ID NO 1096 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1096 Ile Pro Ile Pro Ser Ser Trp Ala 1 5 <210> SEQ ID NO 1097 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1097 Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 1098 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1098 Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala 1 5 10 <210> SEQ ID NO 1099 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1099 Ile Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 10 <210> SEQ ID NO 1100 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1100 Ile Pro Met Gly Val Gly Leu Ser Pro Phe Leu 1 5 10 <210> SEQ ID NO 1101 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1101 Ile Pro Gln Ser Leu Asp Ser Trp 1 5 <210> SEQ ID NO 1102 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1102 Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 <210> SEQ ID NO 1103 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1103 Ile Pro Ser Ser Trp Ala Phe Ala 1 5 <210> SEQ ID NO 1104 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1104 Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 <210> SEQ ID NO 1105 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1105 Leu Pro Ile Phe Phe Cys Leu Trp 1 5 <210> SEQ ID NO 1106 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1106 Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 <210> SEQ ID NO 1107 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1107 Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 10 <210> SEQ ID NO 1108 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1108 Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 10 <210> SEQ ID NO 1109 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1109 Leu Pro Ile His Thr Ala Glu Leu 1 5 <210> SEQ ID NO 1110 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1110 Leu Pro Ile His Thr Ala Glu Leu Leu 1 5 <210> SEQ ID NO 1111 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1111 Leu Pro Ile His Thr Ala Glu Leu Leu Ala 1 5 10 <210> SEQ ID NO 1112 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1112 Leu Pro Ile His Thr Ala Glu Leu Leu Ala Ala 1 5 10 <210> SEQ ID NO 1113 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1113 Leu Pro Lys Val Leu His Lys Arg Thr Leu 1 5 10 <210> SEQ ID NO 1114 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1114 Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 10 <210> SEQ ID NO 1115 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1115 Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 1116 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1116 Leu Pro Val Cys Ala Phe Ser Ser Ala 1 5 <210> SEQ ID NO 1117 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1117 Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 <210> SEQ ID NO 1118 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 1118 Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val 1 5 10 <210> SEQ ID NO 1119 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1119 Met Pro His Leu Leu Val Gly Ser Ser Gly Leu 1 5 10 <210> SEQ ID NO 1120 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1120 Met Pro Leu Ser Tyr Gln His Phe 1 5 <210> SEQ ID NO 1121 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1121 Met Pro Leu Ser Tyr Gln His Phe Arg Lys Leu 1 5 10 <210> SEQ ID NO 1122 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1122 Asn Pro Ala Asp Asp Pro Ser Arg Gly Arg Leu 1 5 10 <210> SEQ ID NO 1123 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1123 Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu 1 5 10 <210> SEQ ID NO 1124 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1124 Asn Pro Asn Lys Thr Lys Arg Trp 1 5 <210> SEQ ID NO 1125 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1125 Asn Pro Asn Lys Thr Lys Arg Trp Gly Tyr 1 5 10 <210> SEQ ID NO 1126 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1126 Pro Pro Ala Tyr Arg Pro Pro Asn Ala 1 5 <210> SEQ ID NO 1127 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1127 Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 10 <210> SEQ ID NO 1128 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1128 Pro Pro His Gly Gly Leu Leu Gly Trp 1 5 <210> SEQ ID NO 1129 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1129 Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu 1 5 10 <210> SEQ ID NO 1130 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1130 Arg Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 10 <210> SEQ ID NO 1131 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1131 Arg Pro Pro Asn Ala Pro Ile Leu 1 5 <210> SEQ ID NO 1132 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1132 Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu 1 5 10 <210> SEQ ID NO 1133 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1133 Ser Pro Glu His Cys Ser Pro His His Thr Ala 1 5 10 <210> SEQ ID NO 1134 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1134 Ser Pro Phe Leu Leu Ala Gln Phe 1 5 <210> SEQ ID NO 1135 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1135 Ser Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 1136 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1136 Ser Pro His His Thr Ala Leu Arg Gln Ala 1 5 10 <210> SEQ ID NO 1137 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1137 Ser Pro His His Thr Ala Leu Arg Gln Ala Ile 1 5 10 <210> SEQ ID NO 1138 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1138 Ser Pro Gln Ala Gln Gly Ile Leu 1 5 <210> SEQ ID NO 1139 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1139 Ser Pro Ser Val Pro Ser His Leu 1 5 <210> SEQ ID NO 1140 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1140 Ser Pro Thr Val Trp Leu Ser Val 1 5 <210> SEQ ID NO 1141 <211> LENGTH: 9 <212> TYPE: PRT

<213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1141 Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 <210> SEQ ID NO 1142 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1142 Ser Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 10 <210> SEQ ID NO 1143 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1143 Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met 1 5 10 <210> SEQ ID NO 1144 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1144 Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 <210> SEQ ID NO 1145 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1145 Thr Pro Ala Arg Val Thr Gly Gly Val 1 5 <210> SEQ ID NO 1146 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1146 Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 1147 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1147 Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu 1 5 10 <210> SEQ ID NO 1148 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1148 Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala 1 5 10 <210> SEQ ID NO 1149 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1149 Thr Pro Pro His Gly Gly Leu Leu 1 5 <210> SEQ ID NO 1150 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1150 Thr Pro Pro His Gly Gly Leu Leu Gly Trp 1 5 10 <210> SEQ ID NO 1151 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1151 Thr Pro Thr Gly Trp Gly Leu Ala 1 5 <210> SEQ ID NO 1152 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1152 Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 <210> SEQ ID NO 1153 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1153 Val Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 1154 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1154 Val Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 10 <210> SEQ ID NO 1155 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1155 Val Pro Asn Leu Gln Ser Leu Thr Asn Leu 1 5 10 <210> SEQ ID NO 1156 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1156 Val Pro Asn Leu Gln Ser Leu Thr Asn Leu Leu 1 5 10 <210> SEQ ID NO 1157 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1157 Val Pro Ser Ala Leu Asn Pro Ala 1 5 <210> SEQ ID NO 1158 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1158 Trp Pro Lys Phe Ala Val Pro Asn Leu 1 5 <210> SEQ ID NO 1159 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1159 Tyr Pro Ala Leu Met Pro Leu Tyr 1 5 <210> SEQ ID NO 1160 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1160 Tyr Pro Ala Leu Met Pro Leu Tyr Ala 1 5 <210> SEQ ID NO 1161 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1161 Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 10 <210> SEQ ID NO 1162 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1162 Ala His Leu Ser Leu Arg Gly Leu 1 5 <210> SEQ ID NO 1163 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1163 Ala Lys Ser Val Gln His Leu Glu Ser Leu 1 5 10 <210> SEQ ID NO 1164

<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1164 Ala Arg Val Thr Gly Gly Val Phe 1 5 <210> SEQ ID NO 1165 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1165 Ala Arg Val Thr Gly Gly Val Phe Leu 1 5 <210> SEQ ID NO 1166 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1166 Asp His Gly Ala His Leu Ser Leu 1 5 <210> SEQ ID NO 1167 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1167 Asp His Gly Ala His Leu Ser Leu Arg Gly Leu 1 5 10 <210> SEQ ID NO 1168 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1168 Asp His Gln Leu Asp Pro Ala Phe 1 5 <210> SEQ ID NO 1169 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1169 Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 <210> SEQ ID NO 1170 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1170 Glu His Cys Ser Pro His His Thr Ala Leu 1 5 10 <210> SEQ ID NO 1171 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1171 Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 1172 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1172 Phe Arg Lys Ile Pro Met Gly Val Gly Leu 1 5 10 <210> SEQ ID NO 1173 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1173 Phe Arg Lys Leu Pro Val Asn Arg Pro Ile 1 5 10 <210> SEQ ID NO 1174 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1174 Gly Arg Glu Thr Val Leu Glu Tyr 1 5 <210> SEQ ID NO 1175 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1175 Gly Arg Glu Thr Val Leu Glu Tyr Leu 1 5 <210> SEQ ID NO 1176 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1176 His His Thr Ala Leu Arg Gln Ala Ile 1 5 <210> SEQ ID NO 1177 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1177 His His Thr Ala Leu Arg Gln Ala Ile Leu 1 5 10 <210> SEQ ID NO 1178 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1178 His Lys Val Gly Asn Phe Thr Gly Leu 1 5 <210> SEQ ID NO 1179 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1179 His Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 10 <210> SEQ ID NO 1180 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1180 Ile His Leu Asn Pro Asn Lys Thr Lys Arg Trp 1 5 10 <210> SEQ ID NO 1181 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1181 Ile His Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 10 <210> SEQ ID NO 1182 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1182 Lys Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 1183 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1183 Lys Arg Trp Gly Tyr Ser Leu Asn Phe Met 1 5 10 <210> SEQ ID NO 1184 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1184 Leu His Lys Arg Thr Leu Gly Leu 1 5 <210> SEQ ID NO 1185 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1185 Leu His Leu Tyr Ser His Pro Ile 1 5 <210> SEQ ID NO 1186 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1186 Leu His Leu Tyr Ser His Pro Ile Ile 1 5

<210> SEQ ID NO 1187 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1187 Leu His Leu Tyr Ser His Pro Ile Ile Leu 1 5 10 <210> SEQ ID NO 1188 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1188 Leu His Pro Ala Ala Met Pro His Leu 1 5 <210> SEQ ID NO 1189 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1189 Leu His Pro Ala Ala Met Pro His Leu Leu 1 5 10 <210> SEQ ID NO 1190 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1190 Leu His Thr Leu Trp Lys Ala Gly Ile 1 5 <210> SEQ ID NO 1191 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1191 Leu His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 10 <210> SEQ ID NO 1192 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1192 Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 1193 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1193 Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 <210> SEQ ID NO 1194 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1194 Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 10 <210> SEQ ID NO 1195 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1195 Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 <210> SEQ ID NO 1196 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1196 Leu Arg Gly Thr Ser Phe Val Tyr 1 5 <210> SEQ ID NO 1197 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1197 Leu Arg Gln Ala Ile Leu Cys Trp 1 5 <210> SEQ ID NO 1198 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1198 Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu 1 5 10 <210> SEQ ID NO 1199 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1199 Leu Arg Arg Phe Ile Ile Phe Leu 1 5 <210> SEQ ID NO 1200 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1200 Leu Arg Arg Phe Ile Ile Phe Leu Phe 1 5 <210> SEQ ID NO 1201 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1201 Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile 1 5 10 <210> SEQ ID NO 1202 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1202 Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu 1 5 10 <210> SEQ ID NO 1203 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1203 Asn Lys Thr Lys Arg Trp Gly Tyr 1 5 <210> SEQ ID NO 1204 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1204 Asn Lys Thr Lys Arg Trp Gly Tyr Ser Leu 1 5 10 <210> SEQ ID NO 1205 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1205 Asn Arg Arg Val Ala Glu Asp Leu 1 5 <210> SEQ ID NO 1206 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1206 Asn Arg Arg Val Ala Glu Asp Leu Asn Leu 1 5 10 <210> SEQ ID NO 1207 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1207 Pro His Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 1208 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1208 Pro His Cys Leu Ala Phe Ser Tyr Met 1 5 <210> SEQ ID NO 1209 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1209 Pro His Gly Gly Leu Leu Gly Trp

1 5 <210> SEQ ID NO 1210 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1210 Pro His His Thr Ala Leu Arg Gln Ala Ile 1 5 10 <210> SEQ ID NO 1211 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1211 Pro His His Thr Ala Leu Arg Gln Ala Ile Leu 1 5 10 <210> SEQ ID NO 1212 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1212 Pro His Leu Leu Val Gly Ser Ser Gly Leu 1 5 10 <210> SEQ ID NO 1213 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1213 Pro Lys Phe Ala Val Pro Asn Leu 1 5 <210> SEQ ID NO 1214 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1214 Pro Lys Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 10 <210> SEQ ID NO 1215 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1215 Pro Lys Val Leu His Lys Arg Thr Leu 1 5 <210> SEQ ID NO 1216 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1216 Pro Lys Val Leu His Lys Arg Thr Leu Gly Leu 1 5 10 <210> SEQ ID NO 1217 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1217 Gln His Phe Arg Lys Leu Leu Leu 1 5 <210> SEQ ID NO 1218 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1218 Gln His Phe Arg Lys Leu Leu Leu Leu 1 5 <210> SEQ ID NO 1219 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1219 Gln Arg Ile Val Gly Leu Leu Gly Phe 1 5 <210> SEQ ID NO 1220 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1220 Arg His Tyr Leu His Thr Leu Trp 1 5 <210> SEQ ID NO 1221 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1221 Arg Lys Ile Pro Met Gly Val Gly Leu 1 5 <210> SEQ ID NO 1222 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1222 Arg Lys Leu Pro Val Asn Arg Pro Ile 1 5 <210> SEQ ID NO 1223 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1223 Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 <210> SEQ ID NO 1224 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1224 Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 <210> SEQ ID NO 1225 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1225 Arg Lys Tyr Thr Ser Phe Pro Trp Leu 1 5 <210> SEQ ID NO 1226 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1226 Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 10 <210> SEQ ID NO 1227 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1227 Arg Arg Ala Phe Pro His Cys Leu 1 5 <210> SEQ ID NO 1228 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1228 Arg Arg Ala Phe Pro His Cys Leu Ala Phe 1 5 10 <210> SEQ ID NO 1229 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1229 Arg Arg Phe Ile Ile Phe Leu Phe 1 5 <210> SEQ ID NO 1230 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1230 Arg Arg Phe Ile Ile Phe Leu Phe Ile 1 5 <210> SEQ ID NO 1231 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1231 Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu 1 5 10 <210> SEQ ID NO 1232 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1232

Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 10 <210> SEQ ID NO 1233 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1233 Arg Arg Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 10 <210> SEQ ID NO 1234 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1234 Arg Arg Val Ala Glu Asp Leu Asn Leu 1 5 <210> SEQ ID NO 1235 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1235 Ser His Pro Ile Ile Leu Gly Phe 1 5 <210> SEQ ID NO 1236 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1236 Ser His Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 10 <210> SEQ ID NO 1237 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1237 Ser Lys Leu Cys Leu Gly Trp Leu 1 5 <210> SEQ ID NO 1238 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1238 Ser Lys Leu Cys Leu Gly Trp Leu Trp 1 5 <210> SEQ ID NO 1239 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1239 Ser Lys Leu Cys Leu Gly Trp Leu Trp Gly Met 1 5 10 <210> SEQ ID NO 1240 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1240 Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 <210> SEQ ID NO 1241 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1241 Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu 1 5 10 <210> SEQ ID NO 1242 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1242 Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 10 <210> SEQ ID NO 1243 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1243 Ser Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 10 <210> SEQ ID NO 1244 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1244 Ser Arg Asn Leu Tyr Val Ser Leu 1 5 <210> SEQ ID NO 1245 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1245 Thr His Lys Val Gly Asn Phe Thr Gly Leu 1 5 10 <210> SEQ ID NO 1246 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1246 Thr His Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 10 <210> SEQ ID NO 1247 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1247 Thr Lys Arg Trp Gly Tyr Ser Leu 1 5 <210> SEQ ID NO 1248 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1248 Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 1249 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1249 Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe Met 1 5 10 <210> SEQ ID NO 1250 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1250 Thr Lys Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 10 <210> SEQ ID NO 1251 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1251 Thr Arg His Tyr Leu His Thr Leu 1 5 <210> SEQ ID NO 1252 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1252 Thr Arg His Tyr Leu His Thr Leu Trp 1 5 <210> SEQ ID NO 1253 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1253 Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 <210> SEQ ID NO 1254 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1254 Val His Phe Ala Ser Pro Leu His Val Ala Trp 1 5 10 <210> SEQ ID NO 1255 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 1255 Val Arg Phe Ser Trp Leu Ser Leu 1 5 <210> SEQ ID NO 1256 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1256 Val Arg Phe Ser Trp Leu Ser Leu Leu 1 5 <210> SEQ ID NO 1257 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1257 Val Arg Arg Ala Phe Pro His Cys Leu 1 5 <210> SEQ ID NO 1258 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1258 Val Arg Arg Ala Phe Pro His Cys Leu Ala Phe 1 5 10 <210> SEQ ID NO 1259 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1259 Trp Lys Val Cys Gln Arg Ile Val Gly Leu 1 5 10 <210> SEQ ID NO 1260 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1260 Trp Lys Val Cys Gln Arg Ile Val Gly Leu Leu 1 5 10 <210> SEQ ID NO 1261 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1261 Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 <210> SEQ ID NO 1262 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1262 Tyr Arg Pro Pro Asn Ala Pro Ile Leu 1 5 <210> SEQ ID NO 1263 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1263 Tyr Arg Trp Met Cys Leu Arg Arg Phe 1 5 <210> SEQ ID NO 1264 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1264 Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile 1 5 10 <210> SEQ ID NO 1265 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1265 Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 10 <210> SEQ ID NO 1266 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1266 Ala Asp Ala Thr Pro Thr Gly Trp 1 5 <210> SEQ ID NO 1267 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1267 Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 <210> SEQ ID NO 1268 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1268 Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu Ala 1 5 10 <210> SEQ ID NO 1269 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1269 Ala Asp Asp Pro Ser Arg Gly Arg Leu 1 5 <210> SEQ ID NO 1270 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1270 Ala Asp Asp Pro Ser Arg Gly Arg Leu Gly Leu 1 5 10 <210> SEQ ID NO 1271 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1271 Ala Glu Asp Leu Asn Leu Gly Asn Leu 1 5 <210> SEQ ID NO 1272 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1272 Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val 1 5 10 <210> SEQ ID NO 1273 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1273 Ala Glu Leu Leu Ala Ala Cys Phe 1 5 <210> SEQ ID NO 1274 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1274 Ala Glu Leu Leu Ala Ala Cys Phe Ala 1 5 <210> SEQ ID NO 1275 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1275 Asp Asp Pro Ser Arg Gly Arg Leu 1 5 <210> SEQ ID NO 1276 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1276 Asp Asp Pro Ser Arg Gly Arg Leu Gly Leu 1 5 10 <210> SEQ ID NO 1277 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1277 Asp Asp Val Val Leu Gly Ala Lys Ser Val 1 5 10 <210> SEQ ID NO 1278 <211> LENGTH: 10

<212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1278 Asp Glu Ala Gly Pro Leu Glu Glu Glu Leu 1 5 10 <210> SEQ ID NO 1279 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1279 Glu Asp Leu Asn Leu Gly Asn Leu 1 5 <210> SEQ ID NO 1280 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1280 Glu Asp Leu Asn Leu Gly Asn Leu Asn Val 1 5 10 <210> SEQ ID NO 1281 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1281 Glu Glu Glu Leu Pro Arg Leu Ala 1 5 <210> SEQ ID NO 1282 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1282 Glu Glu Leu Gly Glu Glu Ile Arg Leu 1 5 <210> SEQ ID NO 1283 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1283 Ile Asp Pro Tyr Lys Glu Phe Gly Ala 1 5 <210> SEQ ID NO 1284 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1284 Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 <210> SEQ ID NO 1285 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1285 Ile Asp Trp Lys Val Cys Gln Arg Ile Val 1 5 10 <210> SEQ ID NO 1286 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1286 Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 <210> SEQ ID NO 1287 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1287 Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 <210> SEQ ID NO 1288 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1288 Leu Asp Pro Ala Arg Asp Val Leu 1 5 <210> SEQ ID NO 1289 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1289 Leu Asp Pro Ala Arg Asp Val Leu Cys Leu 1 5 10 <210> SEQ ID NO 1290 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1290 Leu Asp Ser Trp Trp Thr Ser Leu 1 5 <210> SEQ ID NO 1291 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1291 Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 1292 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1292 Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu 1 5 10 <210> SEQ ID NO 1293 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1293 Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 <210> SEQ ID NO 1294 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1294 Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala 1 5 10 <210> SEQ ID NO 1295 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1295 Leu Asp Val Ser Ala Ala Phe Tyr 1 5 <210> SEQ ID NO 1296 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1296 Leu Asp Tyr Gln Gly Met Leu Pro Val 1 5 <210> SEQ ID NO 1297 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1297 Leu Glu Glu Glu Leu Pro Arg Leu 1 5 <210> SEQ ID NO 1298 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1298 Leu Glu Glu Glu Leu Pro Arg Leu Ala 1 5 <210> SEQ ID NO 1299 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1299 Met Asp Asp Val Val Leu Gly Ala 1 5 <210> SEQ ID NO 1300 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1300 Met Asp Asp Val Val Leu Gly Ala Lys Ser Val 1 5 10

<210> SEQ ID NO 1301 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1301 Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 1302 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1302 Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala 1 5 10 <210> SEQ ID NO 1303 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1303 Pro Asp His Gln Leu Asp Pro Ala 1 5 <210> SEQ ID NO 1304 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1304 Pro Asp His Gln Leu Asp Pro Ala Phe 1 5 <210> SEQ ID NO 1305 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1305 Pro Glu His Cys Ser Pro His His Thr Ala 1 5 10 <210> SEQ ID NO 1306 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1306 Pro Glu His Cys Ser Pro His His Thr Ala Leu 1 5 10 <210> SEQ ID NO 1307 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1307 Arg Asp Leu Leu Asp Thr Ala Ser Ala 1 5 <210> SEQ ID NO 1308 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1308 Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu 1 5 10 <210> SEQ ID NO 1309 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1309 Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 1310 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1310 Arg Asp Val Leu Cys Leu Arg Pro Val 1 5 <210> SEQ ID NO 1311 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1311 Arg Asp Val Leu Cys Leu Arg Pro Val Gly Ala 1 5 10 <210> SEQ ID NO 1312 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1312 Arg Glu Thr Val Leu Glu Tyr Leu 1 5 <210> SEQ ID NO 1313 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1313 Arg Glu Thr Val Leu Glu Tyr Leu Val 1 5 <210> SEQ ID NO 1314 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1314 Thr Asp Asn Ser Val Val Leu Ser Arg Lys Tyr 1 5 10 <210> SEQ ID NO 1315 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1315 Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 10 <210> SEQ ID NO 1316 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1316 Trp Glu Glu Leu Gly Glu Glu Ile 1 5 <210> SEQ ID NO 1317 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1317 Trp Glu Glu Leu Gly Glu Glu Ile Arg Leu 1 5 10 <210> SEQ ID NO 1318 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1318 Ala Ala Met Pro His Leu Leu Val 1 5 <210> SEQ ID NO 1319 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1319 Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 <210> SEQ ID NO 1320 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1320 Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 <210> SEQ ID NO 1321 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1321 Ala Ser Phe Cys Gly Ser Pro Tyr 1 5 <210> SEQ ID NO 1322 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1322 Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp 1 5 10 <210> SEQ ID NO 1323 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1323 Ala Ser Lys Leu Cys Leu Gly Trp 1 5

<210> SEQ ID NO 1324 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1324 Ala Ser Lys Leu Cys Leu Gly Trp Leu 1 5 <210> SEQ ID NO 1325 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1325 Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp 1 5 10 <210> SEQ ID NO 1326 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1326 Ala Ser Pro Leu His Val Ala Trp 1 5 <210> SEQ ID NO 1327 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1327 Ala Ser Val Arg Phe Ser Trp Leu 1 5 <210> SEQ ID NO 1328 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1328 Ala Ser Val Arg Phe Ser Trp Leu Ser Leu 1 5 10 <210> SEQ ID NO 1329 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1329 Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 1 5 10 <210> SEQ ID NO 1330 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1330 Ala Thr Pro Thr Gly Trp Gly Leu 1 5 <210> SEQ ID NO 1331 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1331 Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 10 <210> SEQ ID NO 1332 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1332 Cys Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 10 <210> SEQ ID NO 1333 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1333 Cys Ser Pro His His Thr Ala Leu 1 5 <210> SEQ ID NO 1334 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1334 Cys Ser Arg Asn Leu Tyr Val Ser Leu 1 5 <210> SEQ ID NO 1335 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1335 Cys Ser Val Val Arg Arg Ala Phe 1 5 <210> SEQ ID NO 1336 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1336 Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp 1 5 10 <210> SEQ ID NO 1337 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1337 Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 <210> SEQ ID NO 1338 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1338 Asp Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile 1 5 10 <210> SEQ ID NO 1339 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1339 Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 1340 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1340 Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu 1 5 10 <210> SEQ ID NO 1341 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1341 Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala 1 5 10 <210> SEQ ID NO 1342 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1342 Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 <210> SEQ ID NO 1343 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1343 Glu Ala Gly Pro Leu Glu Glu Glu Leu 1 5 <210> SEQ ID NO 1344 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1344 Glu Ser Arg Leu Val Val Asp Phe 1 5 <210> SEQ ID NO 1345 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1345 Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 10 <210> SEQ ID NO 1346 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1346

Glu Thr Val Leu Glu Tyr Leu Val 1 5 <210> SEQ ID NO 1347 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1347 Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 10 <210> SEQ ID NO 1348 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1348 Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 <210> SEQ ID NO 1349 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1349 Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 <210> SEQ ID NO 1350 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1350 Phe Ala Ser Pro Leu His Val Ala Trp 1 5 <210> SEQ ID NO 1351 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1351 Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 <210> SEQ ID NO 1352 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1352 Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 <210> SEQ ID NO 1353 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1353 Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 <210> SEQ ID NO 1354 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1354 Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 <210> SEQ ID NO 1355 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1355 Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 10 <210> SEQ ID NO 1356 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1356 Phe Ser Trp Leu Ser Leu Leu Val 1 5 <210> SEQ ID NO 1357 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1357 Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 10 <210> SEQ ID NO 1358 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1358 Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val 1 5 10 <210> SEQ ID NO 1359 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1359 Phe Ser Tyr Met Asp Asp Val Val 1 5 <210> SEQ ID NO 1360 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1360 Phe Ser Tyr Met Asp Asp Val Val Leu 1 5 <210> SEQ ID NO 1361 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1361 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 10 <210> SEQ ID NO 1362 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1362 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 10 <210> SEQ ID NO 1363 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1363 Phe Thr Gly Leu Tyr Ser Ser Thr Val 1 5 <210> SEQ ID NO 1364 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1364 Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 <210> SEQ ID NO 1365 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1365 Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met 1 5 10 <210> SEQ ID NO 1366 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1366 Phe Thr Ser Ala Ile Cys Ser Val 1 5 <210> SEQ ID NO 1367 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1367 Phe Thr Ser Ala Ile Cys Ser Val Val 1 5 <210> SEQ ID NO 1368 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1368 Gly Ala His Leu Ser Leu Arg Gly Leu 1 5 <210> SEQ ID NO 1369 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 1369 Gly Ala His Leu Ser Leu Arg Gly Leu Pro Val 1 5 10 <210> SEQ ID NO 1370 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1370 Gly Ala Lys Ser Val Gln His Leu 1 5 <210> SEQ ID NO 1371 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1371 Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu 1 5 10 <210> SEQ ID NO 1372 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1372 Gly Ser Ser Ser Gly Thr Val Asn Pro Val 1 5 10 <210> SEQ ID NO 1373 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1373 Gly Thr Asp Asn Ser Val Val Leu 1 5 <210> SEQ ID NO 1374 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1374 Gly Thr Asn Leu Ser Val Pro Asn Pro Leu 1 5 10 <210> SEQ ID NO 1375 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1375 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 10 <210> SEQ ID NO 1376 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1376 His Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 10 <210> SEQ ID NO 1377 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1377 His Thr Ala Leu Arg Gln Ala Ile 1 5 <210> SEQ ID NO 1378 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1378 His Thr Ala Leu Arg Gln Ala Ile Leu 1 5 <210> SEQ ID NO 1379 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1379 His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 10 <210> SEQ ID NO 1380 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1380 His Thr Leu Trp Lys Ala Gly Ile 1 5 <210> SEQ ID NO 1381 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1381 His Thr Leu Trp Lys Ala Gly Ile Leu 1 5 <210> SEQ ID NO 1382 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1382 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 1383 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1383 Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val 1 5 10 <210> SEQ ID NO 1384 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1384 Lys Ser Val Gln His Leu Glu Ser Leu 1 5 <210> SEQ ID NO 1385 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1385 Lys Thr Lys Arg Trp Gly Tyr Ser Leu 1 5 <210> SEQ ID NO 1386 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1386 Lys Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 1387 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1387 Leu Ala Phe Ser Tyr Met Asp Asp Val 1 5 <210> SEQ ID NO 1388 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1388 Leu Ala Phe Ser Tyr Met Asp Asp Val Val 1 5 10 <210> SEQ ID NO 1389 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1389 Leu Ala Phe Ser Tyr Met Asp Asp Val Val Leu 1 5 10 <210> SEQ ID NO 1390 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1390 Leu Ala Gln Phe Thr Ser Ala Ile 1 5 <210> SEQ ID NO 1391 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1391 Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val 1 5 10 <210> SEQ ID NO 1392 <211> LENGTH: 8 <212> TYPE: PRT

<213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1392 Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 1393 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1393 Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 <210> SEQ ID NO 1394 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1394 Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 1395 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1395 Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 1396 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1396 Leu Ser Leu Leu Val Pro Phe Val 1 5 <210> SEQ ID NO 1397 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1397 Leu Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 10 <210> SEQ ID NO 1398 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1398 Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 1399 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1399 Leu Ser Leu Arg Gly Leu Pro Val 1 5 <210> SEQ ID NO 1400 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1400 Leu Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 1401 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1401 Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 <210> SEQ ID NO 1402 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1402 Leu Ser Pro Thr Val Trp Leu Ser Val 1 5 <210> SEQ ID NO 1403 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1403 Leu Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 10 <210> SEQ ID NO 1404 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1404 Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 10 <210> SEQ ID NO 1405 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1405 Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 1406 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1406 Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 10 <210> SEQ ID NO 1407 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1407 Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu 1 5 10 <210> SEQ ID NO 1408 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1408 Leu Ser Ser Asn Leu Ser Trp Leu 1 5 <210> SEQ ID NO 1409 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1409 Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu 1 5 10 <210> SEQ ID NO 1410 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1410 Leu Ser Thr Leu Pro Glu Thr Thr Val 1 5 <210> SEQ ID NO 1411 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1411 Leu Ser Thr Leu Pro Glu Thr Thr Val Val 1 5 10 <210> SEQ ID NO 1412 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1412 Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 1413 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1413 Leu Ser Trp Leu Ser Leu Asp Val 1 5 <210> SEQ ID NO 1414 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1414 Leu Ser Tyr Gln His Phe Arg Lys Leu 1 5 <210> SEQ ID NO 1415

<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1415 Leu Ser Tyr Gln His Phe Arg Lys Leu Leu 1 5 10 <210> SEQ ID NO 1416 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1416 Leu Ser Tyr Gln His Phe Arg Lys Leu Leu Leu 1 5 10 <210> SEQ ID NO 1417 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1417 Leu Thr Phe Gly Arg Glu Thr Val 1 5 <210> SEQ ID NO 1418 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1418 Leu Thr Phe Gly Arg Glu Thr Val Leu 1 5 <210> SEQ ID NO 1419 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1419 Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 10 <210> SEQ ID NO 1420 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1420 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 1421 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1421 Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 1422 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1422 Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 <210> SEQ ID NO 1423 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1423 Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 10 <210> SEQ ID NO 1424 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1424 Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 <210> SEQ ID NO 1425 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1425 Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 1426 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1426 Met Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 1427 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1427 Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 10 <210> SEQ ID NO 1428 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1428 Asn Ala Pro Ile Leu Ser Thr Leu 1 5 <210> SEQ ID NO 1429 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1429 Asn Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 1430 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1430 Pro Ala Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 1431 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1431 Pro Ala Ala Met Pro His Leu Leu Val 1 5 <210> SEQ ID NO 1432 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1432 Pro Ala Asp Asp Pro Ser Arg Gly Arg Leu 1 5 10 <210> SEQ ID NO 1433 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1433 Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 1 5 10 <210> SEQ ID NO 1434 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1434 Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 10 <210> SEQ ID NO 1435 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1435 Pro Ala Arg Asp Val Leu Cys Leu 1 5 <210> SEQ ID NO 1436 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1436 Pro Ala Arg Asp Val Leu Cys Leu Arg Pro Val 1 5 10 <210> SEQ ID NO 1437 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1437 Pro Ala Arg Val Thr Gly Gly Val 1 5

<210> SEQ ID NO 1438 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1438 Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 <210> SEQ ID NO 1439 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1439 Pro Ala Arg Val Thr Gly Gly Val Phe Leu 1 5 10 <210> SEQ ID NO 1440 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1440 Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val 1 5 10 <210> SEQ ID NO 1441 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1441 Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 10 <210> SEQ ID NO 1442 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1442 Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 1 5 10 <210> SEQ ID NO 1443 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1443 Pro Ser Arg Gly Arg Leu Gly Leu 1 5 <210> SEQ ID NO 1444 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1444 Pro Thr Gly Trp Gly Leu Ala Ile 1 5 <210> SEQ ID NO 1445 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1445 Pro Thr Thr Gly Arg Thr Ser Leu 1 5 <210> SEQ ID NO 1446 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1446 Pro Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 1447 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1447 Pro Thr Val Gln Ala Ser Lys Leu 1 5 <210> SEQ ID NO 1448 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1448 Pro Thr Val Gln Ala Ser Lys Leu Cys Leu 1 5 10 <210> SEQ ID NO 1449 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1449 Pro Thr Val Trp Leu Ser Val Ile 1 5 <210> SEQ ID NO 1450 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1450 Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 1451 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1451 Pro Thr Val Trp Leu Ser Val Ile Trp Met 1 5 10 <210> SEQ ID NO 1452 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1452 Gln Ala Phe Thr Phe Ser Pro Thr Tyr 1 5 <210> SEQ ID NO 1453 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1453 Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu 1 5 10 <210> SEQ ID NO 1454 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1454 Gln Ala Ile Leu Cys Trp Gly Glu Leu 1 5 <210> SEQ ID NO 1455 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1455 Gln Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 10 <210> SEQ ID NO 1456 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1456 Gln Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 10 <210> SEQ ID NO 1457 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1457 Gln Ala Ser Lys Leu Cys Leu Gly Trp 1 5 <210> SEQ ID NO 1458 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1458 Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu 1 5 10 <210> SEQ ID NO 1459 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1459 Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp 1 5 10 <210> SEQ ID NO 1460 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1460 Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu

1 5 10 <210> SEQ ID NO 1461 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1461 Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu 1 5 10 <210> SEQ ID NO 1462 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1462 Arg Ala Phe Pro His Cys Leu Ala Phe 1 5 <210> SEQ ID NO 1463 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1463 Arg Ala Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 10 <210> SEQ ID NO 1464 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1464 Arg Thr Pro Ala Arg Val Thr Gly Gly Val 1 5 10 <210> SEQ ID NO 1465 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1465 Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 1466 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1466 Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 <210> SEQ ID NO 1467 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1467 Ser Ala Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 10 <210> SEQ ID NO 1468 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1468 Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 <210> SEQ ID NO 1469 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1469 Ser Ala Ser Phe Cys Gly Ser Pro Tyr 1 5 <210> SEQ ID NO 1470 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1470 Ser Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp 1 5 10 <210> SEQ ID NO 1471 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1471 Ser Ser Ala Gly Pro Cys Ala Leu 1 5 <210> SEQ ID NO 1472 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1472 Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 10 <210> SEQ ID NO 1473 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1473 Ser Ser Gly Thr Val Asn Pro Val 1 5 <210> SEQ ID NO 1474 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1474 Ser Ser Asn Leu Ser Trp Leu Ser Leu 1 5 <210> SEQ ID NO 1475 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1475 Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp Val 1 5 10 <210> SEQ ID NO 1476 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1476 Ser Ser Ser Gly Thr Val Asn Pro Val 1 5 <210> SEQ ID NO 1477 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1477 Ser Thr Leu Pro Glu Thr Thr Val 1 5 <210> SEQ ID NO 1478 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1478 Ser Thr Leu Pro Glu Thr Thr Val Val 1 5 <210> SEQ ID NO 1479 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1479 Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 1480 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1480 Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 1481 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1481 Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 <210> SEQ ID NO 1482 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1482 Thr Ala Leu Arg Gln Ala Ile Leu 1 5 <210> SEQ ID NO 1483 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1483

Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 10 <210> SEQ ID NO 1484 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1484 Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 <210> SEQ ID NO 1485 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1485 Thr Ser Ala Ile Cys Ser Val Val 1 5 <210> SEQ ID NO 1486 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1486 Thr Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 10 <210> SEQ ID NO 1487 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1487 Thr Ser Gly Phe Leu Gly Pro Leu 1 5 <210> SEQ ID NO 1488 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1488 Thr Ser Gly Phe Leu Gly Pro Leu Leu 1 5 <210> SEQ ID NO 1489 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1489 Thr Ser Gly Phe Leu Gly Pro Leu Leu Val 1 5 10 <210> SEQ ID NO 1490 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1490 Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu 1 5 10 <210> SEQ ID NO 1491 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1491 Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 1492 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1492 Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 1493 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1493 Val Ala Glu Asp Leu Asn Leu Gly Asn Leu 1 5 10 <210> SEQ ID NO 1494 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1494 Val Ser Ile Pro Trp Thr His Lys Val 1 5 <210> SEQ ID NO 1495 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1495 Val Ser Trp Pro Lys Phe Ala Val 1 5 <210> SEQ ID NO 1496 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1496 Val Ser Trp Pro Lys Phe Ala Val Pro Asn Leu 1 5 10 <210> SEQ ID NO 1497 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1497 Val Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 1498 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1498 Trp Ser Pro Gln Ala Gln Gly Ile 1 5 <210> SEQ ID NO 1499 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1499 Trp Ser Pro Gln Ala Gln Gly Ile Leu 1 5 <210> SEQ ID NO 1500 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1500 Trp Thr His Lys Val Gly Asn Phe 1 5 <210> SEQ ID NO 1501 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1501 Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu 1 5 10 <210> SEQ ID NO 1502 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1502 Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 <210> SEQ ID NO 1503 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1503 Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 <210> SEQ ID NO 1504 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1504 Tyr Ser Leu Asn Phe Met Gly Tyr Val 1 5 <210> SEQ ID NO 1505 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1505 Tyr Ser Leu Asn Phe Met Gly Tyr Val Ile 1 5 10 <210> SEQ ID NO 1506 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 1506 Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 1507 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1507 Ala Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 10 <210> SEQ ID NO 1508 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1508 Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 1509 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1509 Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 1510 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1510 Ala Leu Arg Gln Ala Ile Leu Cys Trp 1 5 <210> SEQ ID NO 1511 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1511 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 1512 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1512 Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 <210> SEQ ID NO 1513 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1513 Ala Gln Phe Thr Ser Ala Ile Cys Ser Val 1 5 10 <210> SEQ ID NO 1514 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1514 Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val 1 5 10 <210> SEQ ID NO 1515 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1515 Cys Ile Pro Ile Pro Ser Ser Trp 1 5 <210> SEQ ID NO 1516 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1516 Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 10 <210> SEQ ID NO 1517 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1517 Cys Leu Ala Phe Ser Tyr Met Asp Asp Val 1 5 10 <210> SEQ ID NO 1518 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1518 Cys Leu Ala Phe Ser Tyr Met Asp Asp Val Val 1 5 10 <210> SEQ ID NO 1519 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1519 Cys Leu Gly Trp Leu Trp Gly Met 1 5 <210> SEQ ID NO 1520 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1520 Cys Leu Gly Trp Leu Trp Gly Met Asp Ile 1 5 10 <210> SEQ ID NO 1521 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1521 Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 1522 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1522 Cys Leu Arg Arg Phe Ile Ile Phe 1 5 <210> SEQ ID NO 1523 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1523 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 1 5 10 <210> SEQ ID NO 1524 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1524 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile 1 5 10 <210> SEQ ID NO 1525 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1525 Cys Leu Thr Phe Gly Arg Glu Thr Val 1 5 <210> SEQ ID NO 1526 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1526 Cys Gln Leu Asp Pro Ala Arg Asp Val 1 5 <210> SEQ ID NO 1527 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1527 Cys Gln Arg Ile Val Gly Leu Leu Gly Phe 1 5 10 <210> SEQ ID NO 1528 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1528 Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 1529 <211> LENGTH: 10

<212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1529 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 1530 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1530 Asp Leu Asn Leu Gly Asn Leu Asn Val 1 5 <210> SEQ ID NO 1531 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1531 Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 10 <210> SEQ ID NO 1532 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1532 Asp Pro Arg Val Arg Gly Leu Tyr 1 5 <210> SEQ ID NO 1533 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1533 Asp Val Leu Cys Leu Arg Pro Val 1 5 <210> SEQ ID NO 1534 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1534 Asp Val Val Leu Gly Ala Lys Ser Val 1 5 <210> SEQ ID NO 1535 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1535 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 10 <210> SEQ ID NO 1536 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1536 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 1537 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1537 Phe Ile Leu Leu Leu Cys Leu Ile 1 5 <210> SEQ ID NO 1538 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1538 Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 1539 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1539 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 10 <210> SEQ ID NO 1540 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1540 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 1541 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1541 Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 10 <210> SEQ ID NO 1542 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1542 Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 1543 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1543 Phe Leu Leu Val Leu Leu Asp Tyr 1 5 <210> SEQ ID NO 1544 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1544 Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 1545 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1545 Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 1 5 10 <210> SEQ ID NO 1546 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1546 Phe Pro Asp His Gln Leu Asp Pro Ala Phe 1 5 10 <210> SEQ ID NO 1547 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1547 Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 1548 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1548 Phe Pro His Cys Leu Ala Phe Ser Tyr Met 1 5 10 <210> SEQ ID NO 1549 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1549 Phe Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 10 <210> SEQ ID NO 1550 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1550 Phe Val Gly Leu Ser Pro Thr Val 1 5 <210> SEQ ID NO 1551 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1551 Phe Val Gly Leu Ser Pro Thr Val Trp 1 5

<210> SEQ ID NO 1552 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1552 Phe Val Leu Gly Gly Cys Arg His Lys Leu Val 1 5 10 <210> SEQ ID NO 1553 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1553 Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 1554 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1554 Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 10 <210> SEQ ID NO 1555 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1555 Gly Leu Ser Pro Thr Val Trp Leu Ser Val 1 5 10 <210> SEQ ID NO 1556 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1556 Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 10 <210> SEQ ID NO 1557 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1557 Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 <210> SEQ ID NO 1558 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1558 Gly Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 10 <210> SEQ ID NO 1559 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1559 Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 1560 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1560 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 10 <210> SEQ ID NO 1561 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1561 His Leu Asn Pro Asn Lys Thr Lys Arg Trp 1 5 10 <210> SEQ ID NO 1562 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1562 His Leu Ser Leu Arg Gly Leu Pro Val 1 5 <210> SEQ ID NO 1563 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1563 His Leu Tyr Ser His Pro Ile Ile 1 5 <210> SEQ ID NO 1564 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1564 His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 1565 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1565 His Pro Ala Ala Met Pro His Leu Leu Val 1 5 10 <210> SEQ ID NO 1566 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1566 His Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 10 <210> SEQ ID NO 1567 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1567 Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 1568 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1568 Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 1569 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1569 Ile Leu Cys Trp Gly Glu Leu Met 1 5 <210> SEQ ID NO 1570 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1570 Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 <210> SEQ ID NO 1571 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1571 Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 1572 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1572 Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 10 <210> SEQ ID NO 1573 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1573 Ile Leu Arg Gly Thr Ser Phe Val 1 5 <210> SEQ ID NO 1574 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1574 Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5

<210> SEQ ID NO 1575 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1575 Ile Leu Arg Gly Thr Ser Phe Val Tyr Val 1 5 10 <210> SEQ ID NO 1576 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1576 Ile Leu Ser Thr Leu Pro Glu Thr Thr Val 1 5 10 <210> SEQ ID NO 1577 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1577 Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val 1 5 10 <210> SEQ ID NO 1578 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1578 Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 <210> SEQ ID NO 1579 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1579 Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 1580 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1580 Ile Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 10 <210> SEQ ID NO 1581 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1581 Ile Pro Gln Ser Leu Asp Ser Trp 1 5 <210> SEQ ID NO 1582 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1582 Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 <210> SEQ ID NO 1583 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1583 Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 <210> SEQ ID NO 1584 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1584 Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 10 <210> SEQ ID NO 1585 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1585 Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 10 <210> SEQ ID NO 1586 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1586 Lys Leu Cys Leu Gly Trp Leu Trp 1 5 <210> SEQ ID NO 1587 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1587 Lys Leu Cys Leu Gly Trp Leu Trp Gly Met 1 5 10 <210> SEQ ID NO 1588 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1588 Lys Leu His Leu Tyr Ser His Pro Ile 1 5 <210> SEQ ID NO 1589 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1589 Lys Leu His Leu Tyr Ser His Pro Ile Ile 1 5 10 <210> SEQ ID NO 1590 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1590 Lys Leu Ile Met Pro Ala Arg Phe 1 5 <210> SEQ ID NO 1591 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1591 Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 1592 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1592 Lys Leu Pro Val Asn Arg Pro Ile 1 5 <210> SEQ ID NO 1593 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1593 Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 <210> SEQ ID NO 1594 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1594 Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr 1 5 10 <210> SEQ ID NO 1595 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1595 Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 <210> SEQ ID NO 1596 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1596 Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 1597 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1597

Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 1598 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1598 Leu Leu Ala Gln Phe Thr Ser Ala Ile 1 5 <210> SEQ ID NO 1599 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1599 Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 <210> SEQ ID NO 1600 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1600 Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 <210> SEQ ID NO 1601 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1601 Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 1602 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1602 Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 1603 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1603 Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 <210> SEQ ID NO 1604 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1604 Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 1605 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1605 Leu Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile 1 5 10 <210> SEQ ID NO 1606 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1606 Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 10 <210> SEQ ID NO 1607 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1607 Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 <210> SEQ ID NO 1608 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1608 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 10 <210> SEQ ID NO 1609 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1609 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 10 <210> SEQ ID NO 1610 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1610 Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 1611 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1611 Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 1612 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1612 Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 1613 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1613 Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 1614 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1614 Leu Leu Val Gly Ser Ser Gly Leu 1 5 <210> SEQ ID NO 1615 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1615 Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 <210> SEQ ID NO 1616 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1616 Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 1617 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1617 Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 1618 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1618 Leu Leu Val Pro Phe Val Gln Trp 1 5 <210> SEQ ID NO 1619 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1619 Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 1620 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 1620 Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 <210> SEQ ID NO 1621 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1621 Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 10 <210> SEQ ID NO 1622 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1622 Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 1623 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1623 Leu Pro Ile Phe Phe Cys Leu Trp 1 5 <210> SEQ ID NO 1624 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1624 Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 <210> SEQ ID NO 1625 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1625 Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 10 <210> SEQ ID NO 1626 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1626 Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 10 <210> SEQ ID NO 1627 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1627 Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 10 <210> SEQ ID NO 1628 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1628 Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 1629 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1629 Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 <210> SEQ ID NO 1630 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1630 Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val 1 5 10 <210> SEQ ID NO 1631 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1631 Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile 1 5 10 <210> SEQ ID NO 1632 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1632 Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 1633 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1633 Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 1634 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1634 Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 1635 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1635 Leu Val Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 1636 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1636 Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 1637 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1637 Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 1638 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1638 Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 1639 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1639 Met Pro Leu Ser Tyr Gln His Phe 1 5 <210> SEQ ID NO 1640 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1640 Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 1641 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1641 Asn Leu Gly Asn Leu Asn Val Ser Ile 1 5 <210> SEQ ID NO 1642 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1642 Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp 1 5 10 <210> SEQ ID NO 1643 <211> LENGTH: 9 <212> TYPE: PRT

<213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1643 Asn Leu Leu Ser Ser Asn Leu Ser Trp 1 5 <210> SEQ ID NO 1644 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1644 Asn Leu Asn Val Ser Ile Pro Trp 1 5 <210> SEQ ID NO 1645 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1645 Asn Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 10 <210> SEQ ID NO 1646 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1646 Asn Leu Ser Trp Leu Ser Leu Asp Val 1 5 <210> SEQ ID NO 1647 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1647 Asn Pro Asn Lys Thr Lys Arg Trp 1 5 <210> SEQ ID NO 1648 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1648 Asn Pro Asn Lys Thr Lys Arg Trp Gly Tyr 1 5 10 <210> SEQ ID NO 1649 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1649 Asn Val Ser Ile Pro Trp Thr His Lys Val 1 5 10 <210> SEQ ID NO 1650 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1650 Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 10 <210> SEQ ID NO 1651 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1651 Pro Ile Asp Trp Lys Val Cys Gln Arg Ile Val 1 5 10 <210> SEQ ID NO 1652 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1652 Pro Ile Phe Phe Cys Leu Trp Val 1 5 <210> SEQ ID NO 1653 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1653 Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 <210> SEQ ID NO 1654 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1654 Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 10 <210> SEQ ID NO 1655 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1655 Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 <210> SEQ ID NO 1656 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1656 Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met 1 5 10 <210> SEQ ID NO 1657 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1657 Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val 1 5 10 <210> SEQ ID NO 1658 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1658 Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 1659 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1659 Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 <210> SEQ ID NO 1660 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1660 Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 1661 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1661 Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp 1 5 10 <210> SEQ ID NO 1662 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1662 Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 10 <210> SEQ ID NO 1663 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1663 Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 1664 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1664 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 1665 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1665 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 1666

<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1666 Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 10 <210> SEQ ID NO 1667 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1667 Pro Pro His Gly Gly Leu Leu Gly Trp 1 5 <210> SEQ ID NO 1668 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1668 Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 10 <210> SEQ ID NO 1669 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1669 Pro Gln Ser Leu Asp Ser Trp Trp 1 5 <210> SEQ ID NO 1670 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1670 Pro Val Asn Arg Pro Ile Asp Trp 1 5 <210> SEQ ID NO 1671 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1671 Pro Val Asn Arg Pro Ile Asp Trp Lys Val 1 5 10 <210> SEQ ID NO 1672 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1672 Gln Leu Asp Pro Ala Arg Asp Val 1 5 <210> SEQ ID NO 1673 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1673 Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 10 <210> SEQ ID NO 1674 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1674 Arg Ile Val Gly Leu Leu Gly Phe 1 5 <210> SEQ ID NO 1675 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1675 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 10 <210> SEQ ID NO 1676 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1676 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 10 <210> SEQ ID NO 1677 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1677 Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 1678 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1678 Arg Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 1 5 10 <210> SEQ ID NO 1679 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1679 Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 10 <210> SEQ ID NO 1680 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1680 Arg Gln Leu Leu Trp Phe His Ile 1 5 <210> SEQ ID NO 1681 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1681 Arg Val His Phe Ala Ser Pro Leu His Val 1 5 10 <210> SEQ ID NO 1682 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1682 Arg Val Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 1683 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1683 Ser Ile Pro Trp Thr His Lys Val 1 5 <210> SEQ ID NO 1684 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1684 Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 <210> SEQ ID NO 1685 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1685 Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 1686 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1686 Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 1687 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1687 Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 <210> SEQ ID NO 1688 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1688 Ser Leu Leu Val Pro Phe Val Gln Trp 1 5

<210> SEQ ID NO 1689 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1689 Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 1690 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1690 Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 <210> SEQ ID NO 1691 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1691 Ser Leu Asn Phe Met Gly Tyr Val 1 5 <210> SEQ ID NO 1692 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1692 Ser Leu Asn Phe Met Gly Tyr Val Ile 1 5 <210> SEQ ID NO 1693 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1693 Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 1694 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1694 Ser Pro Phe Leu Leu Ala Gln Phe 1 5 <210> SEQ ID NO 1695 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1695 Ser Pro His His Thr Ala Leu Arg Gln Ala Ile 1 5 10 <210> SEQ ID NO 1696 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1696 Ser Pro Thr Val Trp Leu Ser Val 1 5 <210> SEQ ID NO 1697 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1697 Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 <210> SEQ ID NO 1698 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1698 Ser Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 10 <210> SEQ ID NO 1699 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1699 Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met 1 5 10 <210> SEQ ID NO 1700 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1700 Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 1701 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1701 Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val 1 5 10 <210> SEQ ID NO 1702 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1702 Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 1703 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1703 Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 1704 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1704 Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 <210> SEQ ID NO 1705 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1705 Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 <210> SEQ ID NO 1706 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1706 Thr Leu Pro Glu Thr Thr Val Val 1 5 <210> SEQ ID NO 1707 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1707 Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 1708 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1708 Thr Pro Ala Arg Val Thr Gly Gly Val 1 5 <210> SEQ ID NO 1709 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1709 Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 1710 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1710 Thr Pro Pro His Gly Gly Leu Leu Gly Trp 1 5 10 <210> SEQ ID NO 1711 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1711 Thr Pro Thr Gly Trp Gly Leu Ala Ile

1 5 <210> SEQ ID NO 1712 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1712 Thr Gln Cys Gly Tyr Pro Ala Leu Met 1 5 <210> SEQ ID NO 1713 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1713 Thr Val Gln Ala Ser Lys Leu Cys Leu Gly Trp 1 5 10 <210> SEQ ID NO 1714 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1714 Thr Val Trp Leu Ser Val Ile Trp 1 5 <210> SEQ ID NO 1715 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1715 Thr Val Trp Leu Ser Val Ile Trp Met 1 5 <210> SEQ ID NO 1716 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1716 Val Leu Gly Gly Cys Arg His Lys Leu Val 1 5 10 <210> SEQ ID NO 1717 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1717 Val Leu Leu Asp Tyr Gln Gly Met 1 5 <210> SEQ ID NO 1718 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1718 Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 1719 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1719 Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 1720 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1720 Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp 1 5 10 <210> SEQ ID NO 1721 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1721 Val Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 1722 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1722 Val Gln Ala Ser Lys Leu Cys Leu Gly Trp 1 5 10 <210> SEQ ID NO 1723 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1723 Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val 1 5 10 <210> SEQ ID NO 1724 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1724 Val Val Leu Gly Ala Lys Ser Val 1 5 <210> SEQ ID NO 1725 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1725 Trp Ile Leu Arg Gly Thr Ser Phe 1 5 <210> SEQ ID NO 1726 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1726 Trp Ile Leu Arg Gly Thr Ser Phe Val 1 5 <210> SEQ ID NO 1727 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1727 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 10 <210> SEQ ID NO 1728 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1728 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val 1 5 10 <210> SEQ ID NO 1729 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1729 Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 <210> SEQ ID NO 1730 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1730 Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 <210> SEQ ID NO 1731 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1731 Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile 1 5 10 <210> SEQ ID NO 1732 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1732 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 <210> SEQ ID NO 1733 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1733 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 1734 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1734

Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 1735 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1735 Trp Leu Ser Leu Leu Val Pro Phe Val 1 5 <210> SEQ ID NO 1736 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1736 Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp 1 5 10 <210> SEQ ID NO 1737 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1737 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 10 <210> SEQ ID NO 1738 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1738 Trp Met Cys Leu Arg Arg Phe Ile 1 5 <210> SEQ ID NO 1739 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1739 Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 <210> SEQ ID NO 1740 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1740 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 1741 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1741 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu 1 5 10 <210> SEQ ID NO 1742 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1742 Tyr Leu His Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 1743 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1743 Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 <210> SEQ ID NO 1744 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1744 Tyr Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 10 <210> SEQ ID NO 1745 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1745 Tyr Leu Val Ser Phe Gly Val Trp 1 5 <210> SEQ ID NO 1746 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1746 Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 <210> SEQ ID NO 1747 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1747 Tyr Pro Ala Leu Met Pro Leu Tyr 1 5 <210> SEQ ID NO 1748 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1748 Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 10 <210> SEQ ID NO 1749 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1749 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 1750 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1750 Asp Asn Ser Val Val Leu Ser Arg Lys Tyr 1 5 10 <210> SEQ ID NO 1751 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1751 Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 10 <210> SEQ ID NO 1752 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1752 Gly Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 <210> SEQ ID NO 1753 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1753 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 1754 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1754 Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr 1 5 10 <210> SEQ ID NO 1755 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1755 Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 <210> SEQ ID NO 1756 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1756 Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 1757 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 1757 Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 1758 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1758 Met Ser Thr Thr Asp Leu Glu Ala Tyr 1 5 <210> SEQ ID NO 1759 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1759 Asn Ser Val Val Leu Ser Arg Lys Tyr 1 5 <210> SEQ ID NO 1760 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1760 Pro Leu Asp Lys Gly Ile Lys Pro Tyr 1 5 <210> SEQ ID NO 1761 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1761 Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 10 <210> SEQ ID NO 1762 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1762 Pro Thr Thr Gly Arg Thr Ser Leu Tyr 1 5 <210> SEQ ID NO 1763 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1763 Ser Ala Ser Phe Cys Gly Ser Pro Tyr 1 5 <210> SEQ ID NO 1764 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1764 Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 <210> SEQ ID NO 1765 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1765 Ala Ala Cys Phe Ala Arg Ser Arg 1 5 <210> SEQ ID NO 1766 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1766 Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 <210> SEQ ID NO 1767 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1767 Ala Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 10 <210> SEQ ID NO 1768 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1768 Ala Phe Ser Ser Ala Gly Pro Cys Ala 1 5 <210> SEQ ID NO 1769 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1769 Ala Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 1770 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1770 Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala 1 5 10 <210> SEQ ID NO 1771 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1771 Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg 1 5 10 <210> SEQ ID NO 1772 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1772 Ala Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 1773 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1773 Ala Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 10 <210> SEQ ID NO 1774 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1774 Ala Leu Asn Pro Ala Asp Asp Pro Ser Arg 1 5 10 <210> SEQ ID NO 1775 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1775 Ala Leu Arg Phe Thr Ser Ala Arg 1 5 <210> SEQ ID NO 1776 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1776 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 1777 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1777 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 1778 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1778 Ala Met Gln Trp Asn Ser Thr Thr Phe His 1 5 10 <210> SEQ ID NO 1779 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1779 Ala Ser Pro Leu His Val Ala Trp Arg 1 5 <210> SEQ ID NO 1780 <211> LENGTH: 9

<212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1780 Ala Ser Thr Asn Arg Gln Ser Gly Arg 1 5 <210> SEQ ID NO 1781 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1781 Cys Ala Ala Asn Trp Ile Leu Arg 1 5 <210> SEQ ID NO 1782 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1782 Cys Ala Leu Arg Phe Thr Ser Ala Arg 1 5 <210> SEQ ID NO 1783 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1783 Cys Phe Ala Arg Ser Arg Ser Gly Ala 1 5 <210> SEQ ID NO 1784 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1784 Cys Phe Arg Lys Leu Pro Val Asn Arg 1 5 <210> SEQ ID NO 1785 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1785 Cys Gly Tyr Pro Ala Leu Met Pro Leu Tyr 1 5 10 <210> SEQ ID NO 1786 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1786 Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 10 <210> SEQ ID NO 1787 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1787 Cys Leu Arg Pro Val Gly Ala Glu Ser Arg 1 5 10 <210> SEQ ID NO 1788 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1788 Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 1 5 10 <210> SEQ ID NO 1789 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1789 Cys Ser Pro His His Thr Ala Leu Arg 1 5 <210> SEQ ID NO 1790 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1790 Cys Ser Val Val Arg Arg Ala Phe Pro His 1 5 10 <210> SEQ ID NO 1791 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1791 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 1792 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1792 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 10 <210> SEQ ID NO 1793 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1793 Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 <210> SEQ ID NO 1794 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1794 Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 <210> SEQ ID NO 1795 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1795 Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg 1 5 10 <210> SEQ ID NO 1796 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1796 Glu Leu Leu Ala Ala Cys Phe Ala Arg 1 5 <210> SEQ ID NO 1797 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1797 Glu Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 10 <210> SEQ ID NO 1798 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1798 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 10 <210> SEQ ID NO 1799 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1799 Glu Ser Pro Glu His Cys Ser Pro His 1 5 <210> SEQ ID NO 1800 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1800 Glu Ser Pro Glu His Cys Ser Pro His His 1 5 10 <210> SEQ ID NO 1801 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1801 Glu Thr Thr Val Val Arg Arg Arg 1 5 <210> SEQ ID NO 1802 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1802 Glu Thr Thr Val Val Arg Arg Arg Gly Arg 1 5 10

<210> SEQ ID NO 1803 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1803 Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 10 <210> SEQ ID NO 1804 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1804 Phe Ala Ser Pro Leu His Val Ala Trp Arg 1 5 10 <210> SEQ ID NO 1805 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1805 Phe Phe Pro Asp His Gln Leu Asp Pro Ala 1 5 10 <210> SEQ ID NO 1806 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1806 Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 <210> SEQ ID NO 1807 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1807 Phe Gly Val Glu Pro Ser Gly Ser Gly His 1 5 10 <210> SEQ ID NO 1808 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1808 Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 <210> SEQ ID NO 1809 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1809 Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg 1 5 10 <210> SEQ ID NO 1810 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1810 Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 10 <210> SEQ ID NO 1811 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1811 Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 1812 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1812 Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 10 <210> SEQ ID NO 1813 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1813 Phe Thr Ser Ala Ile Cys Ser Val Val Arg 1 5 10 <210> SEQ ID NO 1814 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1814 Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 10 <210> SEQ ID NO 1815 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1815 Phe Val Leu Gly Gly Cys Arg His Lys 1 5 <210> SEQ ID NO 1816 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1816 Gly Cys Ala Ala Asn Trp Ile Leu Arg 1 5 <210> SEQ ID NO 1817 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1817 Gly Ile His Leu Asn Pro Asn Lys 1 5 <210> SEQ ID NO 1818 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1818 Gly Ile His Leu Asn Pro Asn Lys Thr Lys 1 5 10 <210> SEQ ID NO 1819 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1819 Gly Ile His Leu Asn Pro Asn Lys Thr Lys Arg 1 5 10 <210> SEQ ID NO 1820 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1820 Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 <210> SEQ ID NO 1821 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1821 Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 10 <210> SEQ ID NO 1822 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1822 Gly Met Asp Ile Asp Pro Tyr Lys 1 5 <210> SEQ ID NO 1823 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1823 Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 <210> SEQ ID NO 1824 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1824 Gly Thr Asp Asn Ser Val Val Leu Ser Arg 1 5 10 <210> SEQ ID NO 1825 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1825 Gly Thr Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10

<210> SEQ ID NO 1826 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1826 Gly Val Glu Pro Ser Gly Ser Gly His 1 5 <210> SEQ ID NO 1827 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1827 Gly Val Phe Leu Val Asp Lys Asn Pro His 1 5 10 <210> SEQ ID NO 1828 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1828 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr 1 5 10 <210> SEQ ID NO 1829 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1829 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg 1 5 10 <210> SEQ ID NO 1830 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1830 His Cys Ser Pro His His Thr Ala Leu Arg 1 5 10 <210> SEQ ID NO 1831 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1831 His Phe Ala Ser Pro Leu His Val Ala 1 5 <210> SEQ ID NO 1832 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1832 His Ile Ser Cys Leu Thr Phe Gly Arg 1 5 <210> SEQ ID NO 1833 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1833 His Leu Asn Pro Asn Lys Thr Lys 1 5 <210> SEQ ID NO 1834 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1834 His Leu Asn Pro Asn Lys Thr Lys Arg 1 5 <210> SEQ ID NO 1835 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1835 His Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 10 <210> SEQ ID NO 1836 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1836 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 1837 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1837 Ile Cys Ser Val Val Arg Arg Ala Phe 1 5 <210> SEQ ID NO 1838 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1838 Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 <210> SEQ ID NO 1839 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1839 Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 <210> SEQ ID NO 1840 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1840 Ile Ser Cys Leu Thr Phe Gly Arg 1 5 <210> SEQ ID NO 1841 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1841 Lys Ala Gly Ile Leu Tyr Lys Arg 1 5 <210> SEQ ID NO 1842 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1842 Lys Leu Ile Met Pro Ala Arg Phe Tyr 1 5 <210> SEQ ID NO 1843 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1843 Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys 1 5 10 <210> SEQ ID NO 1844 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1844 Lys Val Phe Val Leu Gly Gly Cys Arg 1 5 <210> SEQ ID NO 1845 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1845 Lys Val Phe Val Leu Gly Gly Cys Arg His 1 5 10 <210> SEQ ID NO 1846 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1846 Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 <210> SEQ ID NO 1847 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1847 Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 <210> SEQ ID NO 1848 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1848

Leu Asp Lys Gly Ile Lys Pro Tyr Tyr 1 5 <210> SEQ ID NO 1849 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1849 Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 1 5 10 <210> SEQ ID NO 1850 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1850 Leu Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 <210> SEQ ID NO 1851 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1851 Leu Asp Val Ser Ala Ala Phe Tyr His 1 5 <210> SEQ ID NO 1852 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1852 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 1853 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1853 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 1854 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1854 Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg 1 5 10 <210> SEQ ID NO 1855 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1855 Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 <210> SEQ ID NO 1856 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1856 Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 <210> SEQ ID NO 1857 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1857 Leu Leu Ala Ala Cys Phe Ala Arg 1 5 <210> SEQ ID NO 1858 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1858 Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg 1 5 10 <210> SEQ ID NO 1859 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1859 Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg 1 5 10 <210> SEQ ID NO 1860 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1860 Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg 1 5 10 <210> SEQ ID NO 1861 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1861 Leu Leu Ser Phe Leu Pro Ser Asp Phe 1 5 <210> SEQ ID NO 1862 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1862 Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 10 <210> SEQ ID NO 1863 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1863 Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 <210> SEQ ID NO 1864 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1864 Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 <210> SEQ ID NO 1865 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1865 Leu Ser Phe Leu Pro Ser Asp Phe Phe 1 5 <210> SEQ ID NO 1866 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1866 Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 1867 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1867 Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 10 <210> SEQ ID NO 1868 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1868 Leu Ser Leu Arg Gly Leu Pro Val Cys Ala 1 5 10 <210> SEQ ID NO 1869 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1869 Leu Ser Pro Phe Leu Leu Ala Gln Phe 1 5 <210> SEQ ID NO 1870 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1870 Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 1871 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 1871 Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 <210> SEQ ID NO 1872 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1872 Leu Ser Trp Leu Ser Leu Asp Val Ser Ala 1 5 10 <210> SEQ ID NO 1873 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1873 Leu Ser Tyr Gln His Phe Arg Lys 1 5 <210> SEQ ID NO 1874 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1874 Leu Thr Val Asn Glu Lys Arg Arg 1 5 <210> SEQ ID NO 1875 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1875 Leu Val Ser Phe Gly Val Trp Ile Arg 1 5 <210> SEQ ID NO 1876 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1876 Leu Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 10 <210> SEQ ID NO 1877 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1877 Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 <210> SEQ ID NO 1878 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1878 Met Asp Asp Val Val Leu Gly Ala Lys 1 5 <210> SEQ ID NO 1879 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1879 Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 1880 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1880 Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 1881 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1881 Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 10 <210> SEQ ID NO 1882 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1882 Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 10 <210> SEQ ID NO 1883 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1883 Asn Phe Leu Leu Ser Leu Gly Ile His 1 5 <210> SEQ ID NO 1884 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1884 Asn Leu Glu Asp Pro Ala Ser Arg 1 5 <210> SEQ ID NO 1885 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1885 Asn Leu Asn Val Ser Ile Pro Trp Thr His 1 5 10 <210> SEQ ID NO 1886 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1886 Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys 1 5 10 <210> SEQ ID NO 1887 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1887 Asn Leu Ser Val Pro Asn Pro Leu Gly Phe 1 5 10 <210> SEQ ID NO 1888 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1888 Asn Ser Gln Ser Pro Thr Ser Asn His 1 5 <210> SEQ ID NO 1889 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1889 Asn Ser Val Val Leu Ser Arg Lys 1 5 <210> SEQ ID NO 1890 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1890 Asn Val Ser Ile Pro Trp Thr His Lys 1 5 <210> SEQ ID NO 1891 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1891 Pro Ala Asp Asp Pro Ser Arg Gly Arg 1 5 <210> SEQ ID NO 1892 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1892 Pro Ala Arg Asp Val Leu Cys Leu Arg 1 5 <210> SEQ ID NO 1893 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1893 Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 <210> SEQ ID NO 1894 <211> LENGTH: 10 <212> TYPE: PRT

<213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1894 Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 1 5 10 <210> SEQ ID NO 1895 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1895 Pro Cys Ala Leu Arg Phe Thr Ser Ala Arg 1 5 10 <210> SEQ ID NO 1896 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1896 Pro Asp His Gln Leu Asp Pro Ala Phe 1 5 <210> SEQ ID NO 1897 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1897 Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 1898 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1898 Pro Phe Thr Gln Cys Gly Tyr Pro Ala 1 5 <210> SEQ ID NO 1899 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1899 Pro Gly Tyr Arg Trp Met Cys Leu Arg 1 5 <210> SEQ ID NO 1900 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1900 Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg 1 5 10 <210> SEQ ID NO 1901 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1901 Pro Ile Asp Trp Lys Val Cys Gln Arg 1 5 <210> SEQ ID NO 1902 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1902 Pro Ile Phe Phe Cys Leu Trp Val Tyr 1 5 <210> SEQ ID NO 1903 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1903 Pro Ile Ile Leu Gly Phe Arg Lys 1 5 <210> SEQ ID NO 1904 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1904 Pro Leu Glu Glu Glu Leu Pro Arg 1 5 <210> SEQ ID NO 1905 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1905 Pro Leu His Pro Ala Ala Met Pro His 1 5 <210> SEQ ID NO 1906 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1906 Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 <210> SEQ ID NO 1907 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1907 Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 <210> SEQ ID NO 1908 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1908 Pro Leu Ser Tyr Gln His Phe Arg 1 5 <210> SEQ ID NO 1909 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1909 Pro Leu Ser Tyr Gln His Phe Arg Lys 1 5 <210> SEQ ID NO 1910 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1910 Pro Leu Thr Val Asn Glu Lys Arg 1 5 <210> SEQ ID NO 1911 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1911 Pro Leu Thr Val Asn Glu Lys Arg Arg 1 5 <210> SEQ ID NO 1912 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1912 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 1913 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1913 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 1914 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1914 Pro Val Gly Ala Glu Ser Arg Gly Arg 1 5 <210> SEQ ID NO 1915 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1915 Pro Val Asn Arg Pro Ile Asp Trp Lys 1 5 <210> SEQ ID NO 1916 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1916 Gln Ala Phe Thr Phe Ser Pro Thr Tyr 1 5 <210> SEQ ID NO 1917

<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1917 Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 10 <210> SEQ ID NO 1918 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1918 Gln Ala Gly Phe Phe Leu Leu Thr Arg 1 5 <210> SEQ ID NO 1919 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1919 Gln Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 10 <210> SEQ ID NO 1920 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1920 Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg 1 5 10 <210> SEQ ID NO 1921 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1921 Gln Ser Ser Gly Ile Leu Ser Arg 1 5 <210> SEQ ID NO 1922 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1922 Arg Ala Phe Pro His Cys Leu Ala Phe 1 5 <210> SEQ ID NO 1923 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1923 Arg Leu Lys Leu Ile Met Pro Ala Arg 1 5 <210> SEQ ID NO 1924 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1924 Arg Leu Lys Leu Ile Met Pro Ala Arg Phe 1 5 10 <210> SEQ ID NO 1925 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1925 Arg Leu Lys Val Phe Val Leu Gly Gly Cys Arg 1 5 10 <210> SEQ ID NO 1926 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1926 Arg Leu Val Val Asp Phe Ser Gln Phe 1 5 <210> SEQ ID NO 1927 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1927 Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 10 <210> SEQ ID NO 1928 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1928 Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro Arg 1 5 10 <210> SEQ ID NO 1929 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1929 Arg Ser Gln Ser Pro Arg Arg Arg 1 5 <210> SEQ ID NO 1930 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1930 Arg Ser Gln Ser Pro Arg Arg Arg Arg 1 5 <210> SEQ ID NO 1931 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1931 Arg Thr Pro Ser Pro Arg Arg Arg 1 5 <210> SEQ ID NO 1932 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1932 Arg Thr Pro Ser Pro Arg Arg Arg Arg 1 5 <210> SEQ ID NO 1933 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1933 Arg Val His Phe Ala Ser Pro Leu His 1 5 <210> SEQ ID NO 1934 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1934 Arg Val Thr Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 1935 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1935 Ser Ala Gly Pro Cys Ala Leu Arg 1 5 <210> SEQ ID NO 1936 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1936 Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 <210> SEQ ID NO 1937 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1937 Ser Ala Ile Cys Ser Val Val Arg 1 5 <210> SEQ ID NO 1938 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1938 Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 1939 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1939 Ser Ala Leu Asn Pro Ala Asp Asp Pro Ser Arg 1 5 10

<210> SEQ ID NO 1940 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1940 Ser Ala Ser Phe Cys Gly Ser Pro Tyr 1 5 <210> SEQ ID NO 1941 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1941 Ser Phe Pro Trp Leu Leu Gly Cys Ala 1 5 <210> SEQ ID NO 1942 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1942 Ser Phe Pro Trp Leu Leu Gly Cys Ala Ala 1 5 10 <210> SEQ ID NO 1943 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1943 Ser Leu Asp Val Ser Ala Ala Phe Tyr His 1 5 10 <210> SEQ ID NO 1944 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1944 Ser Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 10 <210> SEQ ID NO 1945 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1945 Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 <210> SEQ ID NO 1946 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1946 Ser Leu Arg Gly Leu Pro Val Cys Ala Phe 1 5 10 <210> SEQ ID NO 1947 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1947 Ser Ser Ala Gly Pro Cys Ala Leu Arg 1 5 <210> SEQ ID NO 1948 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1948 Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe 1 5 10 <210> SEQ ID NO 1949 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1949 Ser Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 1950 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1950 Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 1951 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1951 Ser Thr Asn Arg Gln Ser Gly Arg 1 5 <210> SEQ ID NO 1952 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1952 Ser Thr Thr Asp Leu Glu Ala Tyr Phe 1 5 <210> SEQ ID NO 1953 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1953 Ser Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 10 <210> SEQ ID NO 1954 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1954 Ser Val Val Arg Arg Ala Phe Pro His 1 5 <210> SEQ ID NO 1955 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1955 Thr Ala Glu Leu Leu Ala Ala Cys Phe 1 5 <210> SEQ ID NO 1956 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1956 Thr Ala Glu Leu Leu Ala Ala Cys Phe Ala Arg 1 5 10 <210> SEQ ID NO 1957 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1957 Thr Asp Asn Ser Val Val Leu Ser Arg 1 5 <210> SEQ ID NO 1958 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1958 Thr Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 <210> SEQ ID NO 1959 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1959 Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 10 <210> SEQ ID NO 1960 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1960 Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 <210> SEQ ID NO 1961 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1961 Thr Gly Gly Val Phe Leu Val Asp Lys 1 5 <210> SEQ ID NO 1962 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1962 Thr Leu Pro Glu Thr Thr Val Val Arg

1 5 <210> SEQ ID NO 1963 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1963 Thr Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 1964 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1964 Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg 1 5 10 <210> SEQ ID NO 1965 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1965 Thr Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 1966 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1966 Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 1967 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1967 Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg 1 5 10 <210> SEQ ID NO 1968 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1968 Thr Ser Ala Ile Cys Ser Val Val Arg 1 5 <210> SEQ ID NO 1969 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1969 Thr Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 10 <210> SEQ ID NO 1970 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1970 Thr Ser Phe Pro Trp Leu Leu Gly Cys Ala 1 5 10 <210> SEQ ID NO 1971 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1971 Thr Ser Phe Val Tyr Val Pro Ser Ala 1 5 <210> SEQ ID NO 1972 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1972 Thr Thr Asp Leu Glu Ala Tyr Phe Lys 1 5 <210> SEQ ID NO 1973 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1973 Thr Thr Ser Thr Gly Pro Cys Lys 1 5 <210> SEQ ID NO 1974 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1974 Thr Thr Val Val Arg Arg Arg Gly Arg 1 5 <210> SEQ ID NO 1975 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1975 Thr Val Val Arg Arg Arg Gly Arg 1 5 <210> SEQ ID NO 1976 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1976 Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg 1 5 10 <210> SEQ ID NO 1977 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1977 Val Phe Leu Val Asp Lys Asn Pro His 1 5 <210> SEQ ID NO 1978 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1978 Val Phe Val Leu Gly Gly Cys Arg His 1 5 <210> SEQ ID NO 1979 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1979 Val Phe Val Leu Gly Gly Cys Arg His Lys 1 5 10 <210> SEQ ID NO 1980 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1980 Val Gly Leu Leu Gly Phe Ala Ala Pro Phe 1 5 10 <210> SEQ ID NO 1981 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1981 Val Gly Pro Leu Thr Val Asn Glu Lys 1 5 <210> SEQ ID NO 1982 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1982 Val Gly Pro Leu Thr Val Asn Glu Lys Arg 1 5 10 <210> SEQ ID NO 1983 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1983 Val Leu Gly Ala Lys Ser Val Gln His 1 5 <210> SEQ ID NO 1984 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1984 Val Leu Gly Gly Cys Arg His Lys 1 5 <210> SEQ ID NO 1985 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1985

Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg 1 5 10 <210> SEQ ID NO 1986 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1986 Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 <210> SEQ ID NO 1987 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1987 Val Ser Phe Gly Val Trp Ile Arg 1 5 <210> SEQ ID NO 1988 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1988 Val Ser Ile Pro Trp Thr His Lys 1 5 <210> SEQ ID NO 1989 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1989 Val Thr Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 1990 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1990 Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 <210> SEQ ID NO 1991 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1991 Val Val Leu Gly Ala Lys Ser Val Gln His 1 5 10 <210> SEQ ID NO 1992 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1992 Val Val Leu Ser Arg Lys Tyr Thr Ser Phe 1 5 10 <210> SEQ ID NO 1993 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1993 Val Val Arg Arg Arg Gly Arg Ser Pro Arg 1 5 10 <210> SEQ ID NO 1994 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1994 Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg 1 5 10 <210> SEQ ID NO 1995 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1995 Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 1996 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1996 Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 1997 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1997 Trp Gly Met Asp Ile Asp Pro Tyr Lys 1 5 <210> SEQ ID NO 1998 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1998 Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr 1 5 10 <210> SEQ ID NO 1999 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 1999 Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 1 5 10 <210> SEQ ID NO 2000 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2000 Trp Ile Arg Thr Pro Pro Ala Tyr Arg 1 5 <210> SEQ ID NO 2001 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2001 Trp Leu Gln Phe Arg Asn Ser Lys 1 5 <210> SEQ ID NO 2002 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2002 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 <210> SEQ ID NO 2003 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2003 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr 1 5 10 <210> SEQ ID NO 2004 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2004 Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr Lys 1 5 10 <210> SEQ ID NO 2005 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2005 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 2006 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2006 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 2007 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2007 Tyr Leu Pro Leu Asp Lys Gly Ile Lys 1 5 <210> SEQ ID NO 2008 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 2008 Tyr Leu Val Ser Phe Gly Val Trp Ile Arg 1 5 10 <210> SEQ ID NO 2009 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2009 Tyr Met Asp Asp Val Val Leu Gly Ala Lys 1 5 10 <210> SEQ ID NO 2010 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2010 Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 <210> SEQ ID NO 2011 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2011 Tyr Ser His Pro Ile Ile Leu Gly Phe Arg 1 5 10 <210> SEQ ID NO 2012 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2012 Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys 1 5 10 <210> SEQ ID NO 2013 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2013 Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 10 <210> SEQ ID NO 2014 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2014 Ala Phe Ser Tyr Met Asp Asp Val Val Leu 1 5 10 <210> SEQ ID NO 2015 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2015 Ala Met Gln Trp Asn Ser Thr Thr Phe 1 5 <210> SEQ ID NO 2016 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2016 Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 <210> SEQ ID NO 2017 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2017 Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 1 5 10 <210> SEQ ID NO 2018 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2018 Glu Tyr Leu Val Ser Phe Gly Val Trp 1 5 <210> SEQ ID NO 2019 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2019 Glu Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 10 <210> SEQ ID NO 2020 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2020 Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 10 <210> SEQ ID NO 2021 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2021 Gly Phe Phe Leu Leu Thr Arg Ile Leu 1 5 <210> SEQ ID NO 2022 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2022 Gly Phe Leu Gly Pro Leu Leu Val Leu 1 5 <210> SEQ ID NO 2023 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2023 Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 <210> SEQ ID NO 2024 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2024 Gly Trp Ser Pro Gln Ala Gln Gly Ile 1 5 <210> SEQ ID NO 2025 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2025 Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu 1 5 10 <210> SEQ ID NO 2026 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2026 Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 1 5 10 <210> SEQ ID NO 2027 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2027 His Phe Ala Ser Pro Leu His Val Ala Trp 1 5 10 <210> SEQ ID NO 2028 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2028 Ile Phe Phe Cys Leu Trp Val Tyr Ile 1 5 <210> SEQ ID NO 2029 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2029 Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 10 <210> SEQ ID NO 2030 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2030 Lys Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 10 <210> SEQ ID NO 2031 <211> LENGTH: 9

<212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2031 Lys Tyr Leu Pro Leu Asp Lys Gly Ile 1 5 <210> SEQ ID NO 2032 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2032 Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 2033 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2033 Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 <210> SEQ ID NO 2034 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2034 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 <210> SEQ ID NO 2035 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2035 Leu Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 10 <210> SEQ ID NO 2036 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2036 Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 2037 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2037 Asn Phe Leu Leu Ser Leu Gly Ile His Leu 1 5 10 <210> SEQ ID NO 2038 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2038 Asn Trp Ile Leu Arg Gly Thr Ser Phe 1 5 <210> SEQ ID NO 2039 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2039 Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu 1 5 10 <210> SEQ ID NO 2040 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2040 Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 <210> SEQ ID NO 2041 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2041 Pro Met Gly Val Gly Leu Ser Pro Phe 1 5 <210> SEQ ID NO 2042 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2042 Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp 1 5 10 <210> SEQ ID NO 2043 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2043 Pro Trp Thr His Lys Val Gly Asn Phe 1 5 <210> SEQ ID NO 2044 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2044 Arg Phe Ile Ile Phe Leu Phe Ile Leu 1 5 <210> SEQ ID NO 2045 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2045 Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 10 <210> SEQ ID NO 2046 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2046 Arg Trp Met Cys Leu Arg Arg Phe Ile 1 5 <210> SEQ ID NO 2047 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2047 Arg Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 10 <210> SEQ ID NO 2048 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2048 Ser Phe Cys Gly Ser Pro Tyr Ser Trp 1 5 <210> SEQ ID NO 2049 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2049 Ser Phe Val Tyr Val Pro Ser Ala Leu 1 5 <210> SEQ ID NO 2050 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2050 Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 2051 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2051 Ser Trp Pro Lys Phe Ala Val Pro Asn Leu 1 5 10 <210> SEQ ID NO 2052 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2052 Ser Trp Trp Thr Ser Leu Asn Phe Leu 1 5 <210> SEQ ID NO 2053 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2053 Ser Tyr Gln His Phe Arg Lys Leu Leu 1 5

<210> SEQ ID NO 2054 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2054 Ser Tyr Gln His Phe Arg Lys Leu Leu Leu 1 5 10 <210> SEQ ID NO 2055 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2055 Thr Phe Ser Pro Thr Tyr Lys Ala Phe 1 5 <210> SEQ ID NO 2056 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2056 Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 10 <210> SEQ ID NO 2057 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2057 Val Phe Ala Asp Ala Thr Pro Thr Gly Trp 1 5 10 <210> SEQ ID NO 2058 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2058 Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 2059 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2059 Trp Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 10 <210> SEQ ID NO 2060 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2060 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 <210> SEQ ID NO 2061 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2061 Ala Ala Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val Pro 1 5 10 15 <210> SEQ ID NO 2062 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2062 Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp 1 5 10 15 <210> SEQ ID NO 2063 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2063 Ala Glu Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg Ser Gly Ala 1 5 10 15 <210> SEQ ID NO 2064 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2064 Ala Phe Ser Tyr Met Asp Asp Val Val Leu Gly Ala Lys Ser Val 1 5 10 15 <210> SEQ ID NO 2065 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2065 Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser 1 5 10 15 <210> SEQ ID NO 2066 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2066 Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala Asp Glu Gly 1 5 10 15 <210> SEQ ID NO 2067 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2067 Ala Lys Leu Ile Gly Thr Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 15 <210> SEQ ID NO 2068 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2068 Ala Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val Pro Ser 1 5 10 15 <210> SEQ ID NO 2069 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2069 Ala Arg Asp Val Leu Cys Leu Arg Pro Val Gly Ala Glu Ser Arg 1 5 10 15 <210> SEQ ID NO 2070 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2070 Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 1 5 10 15 <210> SEQ ID NO 2071 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2071 Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp Gly Met Asp Ile Asp 1 5 10 15 <210> SEQ ID NO 2072 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2072 Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 10 15 <210> SEQ ID NO 2073 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2073 Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val Ser 1 5 10 15 <210> SEQ ID NO 2074 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2074 Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 1 5 10 15 <210> SEQ ID NO 2075 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2075 Cys Pro Thr Val Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp 1 5 10 15 <210> SEQ ID NO 2076 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2076 Cys Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu Ala 1 5 10 15

<210> SEQ ID NO 2077 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2077 Cys Ser Val Val Arg Arg Ala Phe Pro His Cys Leu Ala Phe Ser 1 5 10 15 <210> SEQ ID NO 2078 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2078 Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Arg Phe 1 5 10 15 <210> SEQ ID NO 2079 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2079 Cys Trp Trp Leu Gln Phe Arg Asn Ser Lys Pro Cys Ser Asp Tyr 1 5 10 15 <210> SEQ ID NO 2080 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2080 Asp Asp Val Val Leu Gly Ala Lys Ser Val Gln His Leu Glu Ser 1 5 10 15 <210> SEQ ID NO 2081 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2081 Asp Glu Gly Leu Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly 1 5 10 15 <210> SEQ ID NO 2082 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2082 Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp Thr His 1 5 10 15 <210> SEQ ID NO 2083 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2083 Asp Val Val Leu Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu 1 5 10 15 <210> SEQ ID NO 2084 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2084 Asp Trp Lys Val Cys Gln Arg Ile Val Gly Leu Leu Gly Phe Ala 1 5 10 15 <210> SEQ ID NO 2085 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2085 Glu Ile Arg Leu Lys Val Phe Val Leu Gly Gly Cys Arg His Lys 1 5 10 15 <210> SEQ ID NO 2086 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2086 Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg Gly Asn 1 5 10 15 <210> SEQ ID NO 2087 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2087 Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp 1 5 10 15 <210> SEQ ID NO 2088 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2088 Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn 1 5 10 15 <210> SEQ ID NO 2089 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2089 Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 15 <210> SEQ ID NO 2090 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2090 Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 1 5 10 15 <210> SEQ ID NO 2091 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2091 Phe Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg Gly 1 5 10 15 <210> SEQ ID NO 2092 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2092 Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val Cys 1 5 10 15 <210> SEQ ID NO 2093 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2093 Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 15 <210> SEQ ID NO 2094 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2094 Phe Ser Tyr Met Asp Asp Val Val Leu Gly Ala Lys Ser Val Gln 1 5 10 15 <210> SEQ ID NO 2095 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2095 Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser 1 5 10 15 <210> SEQ ID NO 2096 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2096 Gly Ala His Leu Ser Leu Arg Gly Leu Pro Val Cys Ala Phe Ser 1 5 10 15 <210> SEQ ID NO 2097 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2097 Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 15 <210> SEQ ID NO 2098 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2098 Gly Ile His Leu Asn Pro Asn Lys Thr Lys Arg Trp Gly Tyr Ser 1 5 10 15 <210> SEQ ID NO 2099 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2099

Gly Leu Pro Val Cys Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu 1 5 10 15 <210> SEQ ID NO 2100 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2100 Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn 1 5 10 15 <210> SEQ ID NO 2101 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2101 Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp 1 5 10 15 <210> SEQ ID NO 2102 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2102 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala Asp 1 5 10 15 <210> SEQ ID NO 2103 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2103 Gly Val Phe Leu Val Asp Lys Asn Pro His Asn Thr Thr Glu Ser 1 5 10 15 <210> SEQ ID NO 2104 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2104 Gly Val Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala 1 5 10 15 <210> SEQ ID NO 2105 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2105 Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala 1 5 10 15 <210> SEQ ID NO 2106 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2106 His Gly Gly Leu Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu 1 5 10 15 <210> SEQ ID NO 2107 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2107 His Leu Pro Leu His Pro Ala Ala Met Pro His Leu Leu Val Gly 1 5 10 15 <210> SEQ ID NO 2108 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2108 His Leu Ser Leu Arg Gly Leu Pro Val Cys Ala Phe Ser Ser Ala 1 5 10 15 <210> SEQ ID NO 2109 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2109 His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met 1 5 10 15 <210> SEQ ID NO 2110 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2110 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg Glu Thr Thr 1 5 10 15 <210> SEQ ID NO 2111 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2111 Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 10 15 <210> SEQ ID NO 2112 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2112 Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 15 <210> SEQ ID NO 2113 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2113 Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu Ser Pro 1 5 10 15 <210> SEQ ID NO 2114 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2114 Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 15 <210> SEQ ID NO 2115 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2115 Ile Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala 1 5 10 15 <210> SEQ ID NO 2116 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2116 Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly 1 5 10 15 <210> SEQ ID NO 2117 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2117 Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly 1 5 10 15 <210> SEQ ID NO 2118 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2118 Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile Leu 1 5 10 15 <210> SEQ ID NO 2119 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2119 Lys Phe Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu Leu Ser 1 5 10 15 <210> SEQ ID NO 2120 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2120 Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe Leu Leu Ala Gln 1 5 10 15 <210> SEQ ID NO 2121 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2121 Lys Leu His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys 1 5 10 15 <210> SEQ ID NO 2122 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 2122 Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys 1 5 10 15 <210> SEQ ID NO 2123 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2123 Lys Gln Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 15 <210> SEQ ID NO 2124 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2124 Lys Arg Arg Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr Pro Asn 1 5 10 15 <210> SEQ ID NO 2125 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2125 Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg Ala 1 5 10 15 <210> SEQ ID NO 2126 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2126 Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 15 <210> SEQ ID NO 2127 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2127 Leu Cys Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 15 <210> SEQ ID NO 2128 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2128 Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro 1 5 10 15 <210> SEQ ID NO 2129 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2129 Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu 1 5 10 15 <210> SEQ ID NO 2130 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2130 Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala 1 5 10 15 <210> SEQ ID NO 2131 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2131 Leu Gly Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys Val Gly 1 5 10 15 <210> SEQ ID NO 2132 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2132 Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr 1 5 10 15 <210> SEQ ID NO 2133 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2133 Leu Gly Trp Leu Trp Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 10 15 <210> SEQ ID NO 2134 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2134 Leu His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 10 15 <210> SEQ ID NO 2135 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2135 Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg Glu Thr 1 5 10 15 <210> SEQ ID NO 2136 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2136 Leu Lys Val Phe Val Leu Gly Gly Cys Arg His Lys Leu Val Cys 1 5 10 15 <210> SEQ ID NO 2137 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2137 Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly 1 5 10 15 <210> SEQ ID NO 2138 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2138 Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro 1 5 10 15 <210> SEQ ID NO 2139 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2139 Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala 1 5 10 15 <210> SEQ ID NO 2140 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2140 Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr 1 5 10 15 <210> SEQ ID NO 2141 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2141 Leu Pro Lys Val Leu His Lys Arg Thr Leu Gly Leu Ser Ala Met 1 5 10 15 <210> SEQ ID NO 2142 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2142 Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile Glx 1 5 10 15 <210> SEQ ID NO 2143 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2143 Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 10 15 <210> SEQ ID NO 2144 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2144 Leu Ser Ala Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe Lys Asp 1 5 10 15 <210> SEQ ID NO 2145 <211> LENGTH: 15 <212> TYPE: PRT

<213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2145 Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg Gly Arg 1 5 10 15 <210> SEQ ID NO 2146 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2146 Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Ile 1 5 10 15 <210> SEQ ID NO 2147 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2147 Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp 1 5 10 15 <210> SEQ ID NO 2148 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2148 Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu 1 5 10 15 <210> SEQ ID NO 2149 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2149 Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val 1 5 10 15 <210> SEQ ID NO 2150 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2150 Met Gln Leu Phe His Leu Cys Leu Ile Ile Ser Cys Ser Cys Pro 1 5 10 15 <210> SEQ ID NO 2151 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2151 Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg 1 5 10 15 <210> SEQ ID NO 2152 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2152 Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe 1 5 10 15 <210> SEQ ID NO 2153 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2153 Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His 1 5 10 15 <210> SEQ ID NO 2154 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2154 Asn Arg Pro Ile Asp Trp Lys Val Cys Gln Arg Ile Val Gly Leu 1 5 10 15 <210> SEQ ID NO 2155 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2155 Pro Ala Ala Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser 1 5 10 15 <210> SEQ ID NO 2156 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2156 Pro Asp Arg Val His Phe Ala Ser Pro Leu His Val Ala Trp Arg 1 5 10 15 <210> SEQ ID NO 2157 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2157 Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val 1 5 10 15 <210> SEQ ID NO 2158 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2158 Pro His Cys Leu Ala Phe Ser Tyr Met Asp Asp Val Val Leu Gly 1 5 10 15 <210> SEQ ID NO 2159 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2159 Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu 1 5 10 15 <210> SEQ ID NO 2160 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2160 Pro Leu Pro Ile His Thr Ala Glu Leu Leu Ala Ala Cys Phe Ala 1 5 10 15 <210> SEQ ID NO 2161 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2161 Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu 1 5 10 15 <210> SEQ ID NO 2162 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2162 Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe His Gln Thr Leu 1 5 10 15 <210> SEQ ID NO 2163 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2163 Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly 1 5 10 15 <210> SEQ ID NO 2164 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2164 Gln Cys Gly Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln 1 5 10 15 <210> SEQ ID NO 2165 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2165 Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu 1 5 10 15 <210> SEQ ID NO 2166 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2166 Gln Gln Tyr Val Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 10 15 <210> SEQ ID NO 2167 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2167 Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 10 15 <210> SEQ ID NO 2168

<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2168 Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu 1 5 10 15 <210> SEQ ID NO 2169 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2169 Arg Asp Val Leu Cys Leu Arg Pro Val Gly Ala Glu Ser Arg Gly 1 5 10 15 <210> SEQ ID NO 2170 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2170 Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 15 <210> SEQ ID NO 2171 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2171 Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe 1 5 10 15 <210> SEQ ID NO 2172 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2172 Arg Pro Gly Leu Cys Gln Val Phe Ala Asp Ala Thr Pro Thr Gly 1 5 10 15 <210> SEQ ID NO 2173 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2173 Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 1 5 10 15 <210> SEQ ID NO 2174 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2174 Arg Arg Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asp Asp 1 5 10 15 <210> SEQ ID NO 2175 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2175 Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 10 15 <210> SEQ ID NO 2176 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2176 Arg Arg Ser Phe Gly Val Glu Pro Ser Gly Ser Gly His Ile Asp 1 5 10 15 <210> SEQ ID NO 2177 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2177 Arg Val Ser Trp Pro Lys Phe Ala Val Pro Asn Leu Gln Ser Leu 1 5 10 15 <210> SEQ ID NO 2178 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2178 Arg Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val Ile Gly Ser 1 5 10 15 <210> SEQ ID NO 2179 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2179 Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro 1 5 10 15 <210> SEQ ID NO 2180 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2180 Ser Phe Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg 1 5 10 15 <210> SEQ ID NO 2181 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2181 Ser Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala Asp Asp Pro 1 5 10 15 <210> SEQ ID NO 2182 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2182 Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe 1 5 10 15 <210> SEQ ID NO 2183 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2183 Ser Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val 1 5 10 15 <210> SEQ ID NO 2184 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2184 Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 15 <210> SEQ ID NO 2185 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2185 Ser Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser 1 5 10 15 <210> SEQ ID NO 2186 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2186 Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln 1 5 10 15 <210> SEQ ID NO 2187 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2187 Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 10 15 <210> SEQ ID NO 2188 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2188 Thr Asn Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys 1 5 10 15 <210> SEQ ID NO 2189 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2189 Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp Val 1 5 10 15 <210> SEQ ID NO 2190 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2190 Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr 1 5 10 15

<210> SEQ ID NO 2191 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2191 Thr Ser Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala Asp Asp 1 5 10 15 <210> SEQ ID NO 2192 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2192 Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe 1 5 10 15 <210> SEQ ID NO 2193 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2193 Val Ala Pro Leu Pro Ile His Thr Ala Glu Leu Leu Ala Ala Cys 1 5 10 15 <210> SEQ ID NO 2194 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2194 Val Cys Ala Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe Thr 1 5 10 15 <210> SEQ ID NO 2195 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2195 Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile 1 5 10 15 <210> SEQ ID NO 2196 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2196 Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 1 5 10 15 <210> SEQ ID NO 2197 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2197 Val Gly Asn Phe Thr Gly Leu Tyr Ser Ser Thr Val Pro Val Phe 1 5 10 15 <210> SEQ ID NO 2198 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2198 Val Leu Cys Leu Arg Pro Val Gly Ala Glu Ser Arg Gly Arg Pro 1 5 10 15 <210> SEQ ID NO 2199 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2199 Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val 1 5 10 15 <210> SEQ ID NO 2200 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2200 Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 10 15 <210> SEQ ID NO 2201 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2201 Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Ile Pro Leu 1 5 10 15 <210> SEQ ID NO 2202 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2202 Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu 1 5 10 15 <210> SEQ ID NO 2203 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2203 Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 10 15 <210> SEQ ID NO 2204 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2204 Trp Pro Lys Phe Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu 1 5 10 15 <210> SEQ ID NO 2205 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2205 Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser Lys Gln 1 5 10 15 <210> SEQ ID NO 2206 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2206 Ala Phe Ser Tyr Met Asp Asp Val Val Leu Gly Ala Lys Ser Val 1 5 10 15 <210> SEQ ID NO 2207 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2207 Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys Gln 1 5 10 15 <210> SEQ ID NO 2208 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2208 Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala Asp Glu Gly 1 5 10 15 <210> SEQ ID NO 2209 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2209 Ala Lys Leu Ile Gly Thr Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 15 <210> SEQ ID NO 2210 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2210 Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 1 5 10 15 <210> SEQ ID NO 2211 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2211 Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val Ser 1 5 10 15 <210> SEQ ID NO 2212 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2212 Asp His Gly Ala His Leu Ser Leu Arg Gly Leu Pro Val Cys Ala 1 5 10 15 <210> SEQ ID NO 2213 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2213 Asp Asn Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp

1 5 10 15 <210> SEQ ID NO 2214 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2214 Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg Gly Asn 1 5 10 15 <210> SEQ ID NO 2215 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2215 Phe His Gln Ala Val Leu Asp Pro Arg Val Arg Gly Leu Tyr Leu 1 5 10 15 <210> SEQ ID NO 2216 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2216 Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys 1 5 10 15 <210> SEQ ID NO 2217 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2217 Gly Gly Val Phe Leu Val Asp Lys Asn Pro His Asn Thr Thr Glu 1 5 10 15 <210> SEQ ID NO 2218 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2218 Leu Cys Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 15 <210> SEQ ID NO 2219 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2219 Leu Arg Pro Val Gly Ala Glu Ser Arg Gly Arg Pro Val Ser Gly 1 5 10 15 <210> SEQ ID NO 2220 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2220 Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Ile 1 5 10 15 <210> SEQ ID NO 2221 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2221 Leu Trp Gly Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser 1 5 10 15 <210> SEQ ID NO 2222 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2222 Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val 1 5 10 15 <210> SEQ ID NO 2223 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2223 Asn Val Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr Gly 1 5 10 15 <210> SEQ ID NO 2224 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2224 Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly 1 5 10 15 <210> SEQ ID NO 2225 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2225 Arg Arg Ser Phe Gly Val Glu Pro Ser Gly Ser Gly His Ile Asp 1 5 10 15 <210> SEQ ID NO 2226 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2226 Thr Lys Tyr Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr Pro 1 5 10 15 <210> SEQ ID NO 2227 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2227 Val Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Lys Leu Ile 1 5 10 15 <210> SEQ ID NO 2228 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2228 Tyr Met Asp Asp Val Val Leu Gly Ala 1 5 <210> SEQ ID NO 2229 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2229 Phe Ser Pro Thr Tyr Lys Ala Phe Leu 1 5 <210> SEQ ID NO 2230 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2230 Leu Glu Glu Glu Leu Pro Arg Leu Ala 1 5 <210> SEQ ID NO 2231 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2231 Ile Gly Thr Asp Asn Ser Val Val Leu 1 5 <210> SEQ ID NO 2232 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2232 Leu Tyr Arg Glu Ala Leu Glu Ser Pro 1 5 <210> SEQ ID NO 2233 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2233 Phe Gly Arg Glu Thr Val Leu Glu Tyr 1 5 <210> SEQ ID NO 2234 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2234 Ala His Leu Ser Leu Arg Gly Leu Pro 1 5 <210> SEQ ID NO 2235 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2235 Val Val Leu Ser Arg Lys Tyr Thr Ser 1 5 <210> SEQ ID NO 2236 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2236

Leu Val Val Asp Phe Ser Gln Phe Ser 1 5 <210> SEQ ID NO 2237 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2237 Ala Val Leu Asp Pro Arg Val Arg Gly 1 5 <210> SEQ ID NO 2238 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2238 Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 <210> SEQ ID NO 2239 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2239 Phe Leu Val Asp Lys Asn Pro His Asn 1 5 <210> SEQ ID NO 2240 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2240 Val Phe Ala Asp Ala Thr Pro Thr Gly 1 5 <210> SEQ ID NO 2241 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2241 Val Gly Ala Glu Ser Arg Gly Arg Pro 1 5 <210> SEQ ID NO 2242 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2242 Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 <210> SEQ ID NO 2243 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2243 Met Asp Ile Asp Pro Tyr Lys Glu Phe 1 5 <210> SEQ ID NO 2244 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2244 Val Ala Glu Asp Leu Asn Leu Gly Asn 1 5 <210> SEQ ID NO 2245 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2245 Ile Pro Trp Thr His Lys Val Gly Asn 1 5 <210> SEQ ID NO 2246 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2246 Phe Phe Pro Asp His Gln Leu Asp Pro 1 5 <210> SEQ ID NO 2247 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2247 Phe Gly Val Glu Pro Ser Gly Ser Gly 1 5 <210> SEQ ID NO 2248 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2248 Leu Pro Leu Asp Lys Gly Ile Lys Pro 1 5 <210> SEQ ID NO 2249 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2249 Leu Thr Val Asn Glu Lys Arg Arg Leu 1 5 <210> SEQ ID NO 2250 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2250 Ala Leu Phe Lys Asp Trp Glu Glu Leu 1 5 <210> SEQ ID NO 2251 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV9 <400> SEQUENCE: 2251 Ala Leu Met Pro Leu Tyr Ala Cys Val 1 5 <210> SEQ ID NO 2252 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2252 Ala Leu Met Pro Leu Tyr Ala Ser Ile 1 5 <210> SEQ ID NO 2253 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2253 Ala Leu Met Pro Leu Tyr Ala Xaa Ile 1 5 <210> SEQ ID NO 2254 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2254 Ala Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2255 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 10 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2255 Ala Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2256 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2256 Ala Leu Ser Leu Ile Val Asn Leu Leu 1 5 <210> SEQ ID NO 2257 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide

<400> SEQUENCE: 2257 Ala Met Thr Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 2258 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 17 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2258 Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser 1 5 10 15 Xaa <210> SEQ ID NO 2259 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2259 Cys Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 2260 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2260 Cys Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 2261 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2261 Asp Pro Phe Arg Gly Arg Leu Gly Leu 1 5 <210> SEQ ID NO 2262 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2262 Asp Pro Ser Arg Gly Arg Leu Gly Ile 1 5 <210> SEQ ID NO 2263 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 14 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2263 Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2264 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide LA2.V10 <400> SEQUENCE: 2264 Phe Ala Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2265 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2265 Phe Ile Leu Leu Leu Xaa Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 2266 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2266 Phe Leu Ala Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2267 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.LV1 <400> SEQUENCE: 2267 Phe Leu Gly Leu Ser Pro Thr Val Trp Val 1 5 10 <210> SEQ ID NO 2268 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2268 Phe Leu Lys Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2269 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV10 <400> SEQUENCE: 2269 Phe Leu Leu Ala Gln Phe Thr Ser Ala Val 1 5 10 <210> SEQ ID NO 2270 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.AV9 <400> SEQUENCE: 2270 Phe Leu Leu Ala Gln Phe Thr Ser Val 1 5 <210> SEQ ID NO 2271 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2271 Phe Leu Leu Pro Ile Phe Phe Cys Leu 1 5 <210> SEQ ID NO 2272 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2272 Phe Leu Leu Ser Leu Gly Ile His Val 1 5 <210> SEQ ID NO 2273 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV9 <400> SEQUENCE: 2273 Phe Leu Leu Thr Arg Ile Leu Thr Val 1 5 <210> SEQ ID NO 2274 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2274 Phe Leu Leu Thr Arg Ile Leu Tyr Ile 1 5 <210> SEQ ID NO 2275 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2275

Phe Leu Leu Thr Tyr Ile Leu Thr Ile 1 5 <210> SEQ ID NO 2276 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2276 Phe Leu Met Ser Asp Tyr Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2277 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2277 Phe Leu Met Ser Tyr Phe Pro Ser Val 1 5 <210> SEQ ID NO 2278 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.SA4 <400> SEQUENCE: 2278 Phe Leu Pro Ala Asp Phe Phe Pro Ser Ile 1 5 10 <210> SEQ ID NO 2279 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2279 Phe Leu Pro Ala Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2280 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.SD4 <400> SEQUENCE: 2280 Phe Leu Pro Asp Asp Phe Phe Pro Ser Ala 1 5 10 <210> SEQ ID NO 2281 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2281 Phe Leu Pro Asp Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2282 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.SN4 <400> SEQUENCE: 2282 Phe Leu Pro Asn Asp Phe Phe Pro Ser Ala 1 5 10 <210> SEQ ID NO 2283 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2283 Phe Leu Pro Asn Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2284 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2284 Phe Leu Pro Ser Xaa Tyr Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2285 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2285 Phe Leu Pro Ser Ala Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2286 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2286 Phe Leu Pro Ser Asp Xaa Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2287 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2287 Phe Leu Pro Ser Asp Ala Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2288 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2288 Phe Leu Pro Ser Asp Phe Ala Pro Ser Val 1 5 10 <210> SEQ ID NO 2289 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 7 <223> OTHER INFORMATION: Xaa=F-NH-2 <400> SEQUENCE: 2289 Phe Leu Pro Ser Asp Phe Xaa 1 5 <210> SEQ ID NO 2290 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2290 Phe Leu Pro Ser Asp Phe Phe Ala Ser Val 1 5 10 <210> SEQ ID NO 2291 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2291 Phe Leu Pro Ser Asp Phe Phe Lys Ser Val 1 5 10 <210> SEQ ID NO 2292 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2292 Phe Leu Pro Ser Asp Phe Phe Pro 1 5 <210> SEQ ID NO 2293 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8 <223> OTHER INFORMATION: Xaa=P-NH-2 <400> SEQUENCE: 2293 Phe Leu Pro Ser Asp Phe Phe Xaa

1 5 <210> SEQ ID NO 2294 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2294 Phe Leu Pro Ser Asp Phe Phe Pro Ala Val 1 5 10 <210> SEQ ID NO 2295 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2295 Phe Leu Pro Ser Asp Phe Phe Pro Lys Val 1 5 10 <210> SEQ ID NO 2296 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2296 Phe Leu Pro Ser Asp Phe Phe Pro Ser 1 5 <210> SEQ ID NO 2297 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 9 <223> OTHER INFORMATION: Xaa=S-NH2 <400> SEQUENCE: 2297 Phe Leu Pro Ser Asp Phe Phe Pro Xaa 1 5 <210> SEQ ID NO 2298 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.VA10 <400> SEQUENCE: 2298 Phe Leu Pro Ser Asp Phe Phe Pro Ser Ala 1 5 10 <210> SEQ ID NO 2299 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.VI10 <400> SEQUENCE: 2299 Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile 1 5 10 <210> SEQ ID NO 2300 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 10 <223> OTHER INFORMATION: Xaa=V(CONH2) <400> SEQUENCE: 2300 Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2301 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 10 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2301 Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2302 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2302 Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg 1 5 10 <210> SEQ ID NO 2303 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 11 <223> OTHER INFORMATION: Xaa=R-NH-2 <400> SEQUENCE: 2303 Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Xaa 1 5 10 <210> SEQ ID NO 2304 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2304 Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp 1 5 10 <210> SEQ ID NO 2305 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2305 Phe Leu Pro Ser Asp Phe Tyr Pro Ser Val 1 5 10 <210> SEQ ID NO 2306 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2306 Phe Leu Pro Ser Asp Leu Leu Pro Ser Val Arg 1 5 10 <210> SEQ ID NO 2307 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2307 Phe Leu Pro Ser Asp Tyr Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2308 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2308 Phe Leu Pro Ser Glu Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2309 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.FY5 <400> SEQUENCE: 2309 Phe Leu Pro Ser Tyr Phe Pro Ser Ala 1 5 <210> SEQ ID NO 2310 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.FY5 <400> SEQUENCE: 2310 Phe Leu Pro Ser Tyr Phe Pro Ser Val 1 5 <210> SEQ ID NO 2311 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2311 Phe Leu Pro Ser Glx Phe Phe Pro Ser Val 1 5 10

<210> SEQ ID NO 2312 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2312 Phe Leu Pro Ser Glx Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2313 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.5V4 <400> SEQUENCE: 2313 Phe Leu Pro Val Asp Phe Phe Pro Ser Ile 1 5 10 <210> SEQ ID NO 2314 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2314 Phe Leu Pro Val Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2315 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2315 Phe Leu Ser Lys Gln Tyr Leu Asn Leu 1 5 <210> SEQ ID NO 2316 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2316 Phe Leu Tyr Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 2317 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2317 Phe Met Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 2318 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide IM2.L10 <400> SEQUENCE: 2318 Phe Met Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 <210> SEQ ID NO 2319 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide LM2.V1 <400> SEQUENCE: 2319 Phe Met Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2320 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2320 Phe Pro Ala Ala Met Pro His Leu 1 5 <210> SEQ ID NO 2321 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2321 Phe Pro Ala Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 2322 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2322 Phe Pro Ala Ala Met Pro His Leu Leu Val 1 5 10 <210> SEQ ID NO 2323 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2323 Phe Pro Ala Leu Met Pro Leu Tyr Ala 1 5 <210> SEQ ID NO 2324 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2324 Phe Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 2325 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2325 Phe Pro Cys Ala Leu Arg Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 2326 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2326 Phe Pro Phe Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 2327 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2327 Phe Pro Phe Cys Leu Ala Phe Ser Tyr Met 1 5 10 <210> SEQ ID NO 2328 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2328 Phe Pro His Cys Leu Ala Phe Ala Leu 1 5 <210> SEQ ID NO 2329 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2329 Phe Pro His Cys Leu Ala Phe Ala Tyr 1 5 <210> SEQ ID NO 2330 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2330 Phe Pro His Cys Leu Ala Phe Ser Ala 1 5 <210> SEQ ID NO 2331 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence

<220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2331 Phe Pro His Cys Leu Ala Phe Ser Ile 1 5 <210> SEQ ID NO 2332 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2332 Phe Pro His Cys Leu Ala Phe Ser Leu 1 5 <210> SEQ ID NO 2333 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2333 Phe Pro His Cys Leu Ala Phe Ser Tyr Ile 1 5 10 <210> SEQ ID NO 2334 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2334 Phe Pro His Xaa Leu Ala Phe Ser Tyr Met 1 5 10 <210> SEQ ID NO 2335 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2335 Phe Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2336 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2336 Phe Pro Ser Arg Gly Arg Leu Gly Leu 1 5 <210> SEQ ID NO 2337 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2337 Phe Pro Val Cys Ala Phe Ser Ser Ala 1 5 <210> SEQ ID NO 2338 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2338 Phe Pro Val Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 2339 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2339 Phe Gln Pro Ser Asp Tyr Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2340 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2340 Phe Val Phe Ser Pro Thr Tyr Lys 1 5 <210> SEQ ID NO 2341 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2341 Phe Val Leu Gly Gly Xaa Arg His Lys 1 5 <210> SEQ ID NO 2342 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.AV9 <400> SEQUENCE: 2342 Gly Leu Cys Gln Val Phe Ala Asp Val 1 5 <210> SEQ ID NO 2343 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.AV9 <400> SEQUENCE: 2343 Gly Leu Leu Gly Trp Ser Pro Gln Val 1 5 <210> SEQ ID NO 2344 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.AV9 <400> SEQUENCE: 2344 Gly Leu Trp Ile Arg Thr Pro Pro Val 1 5 <210> SEQ ID NO 2345 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 3 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2345 Gly Leu Xaa Gln Val Phe Ala Asp Ala 1 5 <210> SEQ ID NO 2346 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2346 Gly Met Asp Asn Ser Val Val Leu Ser Arg 1 5 10 <210> SEQ ID NO 2347 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2347 Gly Met Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 <210> SEQ ID NO 2348 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2348 Gly Pro Cys Ala Leu Arg Phe Thr Ser Ile 1 5 10 <210> SEQ ID NO 2349 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2349

Gly Pro Phe Ala Leu Arg Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 2350 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 3 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2350 Gly Pro Xaa Ala Leu Arg Phe Thr Ser Ala 1 5 10 <210> SEQ ID NO 2351 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2351 Gly Thr Phe Asn Ser Val Val Leu Ser Arg 1 5 10 <210> SEQ ID NO 2352 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2352 Gly Thr Phe Asn Ser Val Val Leu Ser Arg Lys 1 5 10 <210> SEQ ID NO 2353 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2353 Gly Val Asp Asn Ser Val Val Leu Ser Arg 1 5 10 <210> SEQ ID NO 2354 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2354 Gly Val Asp Asn Ser Val Val Leu Ser Arg Lys 1 5 10 <210> SEQ ID NO 2355 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2355 Gly Tyr Arg Trp Met Xaa Leu Arg Arg Phe 1 5 10 <210> SEQ ID NO 2356 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2356 His Ile Ser Xaa Leu Thr Phe Gly Arg 1 5 <210> SEQ ID NO 2357 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2357 His Met Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 2358 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2358 His Met Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 2359 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2359 His Pro Ala Ala Met Pro His Ile 1 5 <210> SEQ ID NO 2360 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2360 His Pro Ala Ala Met Pro His Leu Ile 1 5 <210> SEQ ID NO 2361 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2361 His Pro Ala Ala Met Pro His Leu Leu Ile 1 5 10 <210> SEQ ID NO 2362 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2362 His Pro Phe Ala Met Pro His Leu 1 5 <210> SEQ ID NO 2363 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2363 His Pro Phe Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 2364 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2364 His Pro Phe Ala Met Pro His Leu Leu Val 1 5 10 <210> SEQ ID NO 2365 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2365 His Thr Leu Trp Lys Ala Gly Ile Leu Lys 1 5 10 <210> SEQ ID NO 2366 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2366 His Thr Leu Trp Lys Ala Gly Ile Leu Arg 1 5 10 <210> SEQ ID NO 2367 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2367 His Val Leu Trp Lys Ala Gly Ile Leu Tyr 1 5 10 <210> SEQ ID NO 2368

<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2368 His Val Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 2369 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2369 Ile Ile Lys Lys Ser Glu Gln Phe Val 1 5 <210> SEQ ID NO 2370 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.AV9 <400> SEQUENCE: 2370 Ile Leu Gly Leu Leu Gly Phe Ala Val 1 5 <210> SEQ ID NO 2371 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV10 <400> SEQUENCE: 2371 Ile Leu Leu Leu Cys Leu Ile Phe Leu Val 1 5 10 <210> SEQ ID NO 2372 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2372 Ile Leu Leu Leu Xaa Leu Ile Phe Leu 1 5 <210> SEQ ID NO 2373 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2373 Ile Leu Leu Leu Xaa Leu Ile Phe Leu Leu 1 5 10 <210> SEQ ID NO 2374 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2374 Ile Pro Phe Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2375 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2375 Ile Pro Ile Leu Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2376 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2376 Ile Pro Ile Pro Met Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2377 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2377 Ile Pro Ile Pro Ser Ser Trp Ala Ile 1 5 <210> SEQ ID NO 2378 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2378 Ile Pro Ile Thr Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2379 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2379 Lys Ile Lys Glu Ser Phe Arg Lys Leu 1 5 <210> SEQ ID NO 2380 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2380 Lys Leu Phe Leu Tyr Ser His Pro Ile 1 5 <210> SEQ ID NO 2381 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV9 <400> SEQUENCE: 2381 Lys Leu His Leu Tyr Ser His Pro Val 1 5 <210> SEQ ID NO 2382 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2382 Lys Val Gly Asn Phe Thr Gly Leu Lys 1 5 <210> SEQ ID NO 2383 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2383 Lys Val Gly Asn Phe Thr Gly Leu Arg 1 5 <210> SEQ ID NO 2384 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV9 <400> SEQUENCE: 2384 Leu Leu Ala Gln Phe Thr Ser Ala Val 1 5 <210> SEQ ID NO 2385 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2385 Leu Leu Phe Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 2386 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2386 Leu Leu Gly Ser Ala Ala Asn Trp Ile 1 5 <210> SEQ ID NO 2387

<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2387 Leu Leu Gly Xaa Ala Ala Asn Trp Ile Leu 1 5 10 <210> SEQ ID NO 2388 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2388 Leu Leu Leu Xaa Leu Ile Phe Leu Leu 1 5 <210> SEQ ID NO 2389 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2389 Leu Leu Leu Xaa Leu Ile Phe Leu Leu Val 1 5 10 <210> SEQ ID NO 2390 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2390 Leu Leu Leu Tyr Gln Gly Met Leu Pro Val 1 5 10 <210> SEQ ID NO 2391 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.V9 <400> SEQUENCE: 2391 Leu Leu Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 2392 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 7 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2392 Leu Leu Pro Ile Phe Phe Xaa Leu Trp Val 1 5 10 <210> SEQ ID NO 2393 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 13 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2393 Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2394 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2394 Leu Leu Ser Ser Asn Leu Ser Trp Val 1 5 <210> SEQ ID NO 2395 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV10 <400> SEQUENCE: 2395 Leu Leu Val Leu Gln Ala Gly Phe Phe Val 1 5 10 <210> SEQ ID NO 2396 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 3 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2396 Leu Leu Xaa Leu Ile Phe Leu Leu Val 1 5 <210> SEQ ID NO 2397 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VM2.LV <400> SEQUENCE: 2397 Leu Met Leu Leu Asp Tyr Gln Gly Met Val 1 5 10 <210> SEQ ID NO 2398 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VM2.LV <400> SEQUENCE: 2398 Leu Met Leu Gln Ala Gly Phe Phe Leu Val 1 5 10 <210> SEQ ID NO 2399 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VM2.V9 <400> SEQUENCE: 2399 Leu Met Pro Phe Val Gln Trp Phe Val 1 5 <210> SEQ ID NO 2400 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2400 Leu Pro Phe Cys Ala Phe Ser Ser Ala 1 5 <210> SEQ ID NO 2401 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2401 Leu Pro Ile Phe Phe Cys Leu Ile 1 5 <210> SEQ ID NO 2402 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2402 Leu Pro Ile Phe Phe Cys Leu Trp Ile 1 5 <210> SEQ ID NO 2403 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2403 Leu Pro Ile His Thr Ala Glu Leu Ile 1 5 <210> SEQ ID NO 2404 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide

<400> SEQUENCE: 2404 Leu Pro Ile His Thr Ala Glu Leu Leu Ala Ile 1 5 10 <210> SEQ ID NO 2405 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 9 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2405 Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 <210> SEQ ID NO 2406 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2406 Leu Pro Val Cys Ala Phe Ser Ser Ile 1 5 <210> SEQ ID NO 2407 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2407 Leu Pro Val Xaa Ala Phe Ser Ser Ala 1 5 <210> SEQ ID NO 2408 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2408 Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2409 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 12 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2409 Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2410 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2410 Met Met Trp Tyr Trp Gly Pro Ser Leu Lys 1 5 10 <210> SEQ ID NO 2411 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2411 Met Met Trp Tyr Trp Gly Pro Ser Leu Arg 1 5 10 <210> SEQ ID NO 2412 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide M2.LV9 <400> SEQUENCE: 2412 Met Met Trp Tyr Trp Gly Pro Ser Val 1 5 <210> SEQ ID NO 2413 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2413 Met Pro Leu Ser Tyr Gln His Ile 1 5 <210> SEQ ID NO 2414 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV9 <400> SEQUENCE: 2414 Asn Leu Gly Asn Leu Asn Val Ser Val 1 5 <210> SEQ ID NO 2415 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2415 Asn Leu Asn Asn Leu Asn Val Ser Ile 1 5 <210> SEQ ID NO 2416 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2416 Asn Met Gly Leu Lys Tyr Arg Gln Leu 1 5 <210> SEQ ID NO 2417 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2417 Asn Pro Leu Gly Phe Phe Pro Asp His Gln Ile 1 5 10 <210> SEQ ID NO 2418 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2418 Pro Leu Leu Pro Ile Phe Phe Cys Val 1 5 <210> SEQ ID NO 2419 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2419 Pro Leu Leu Pro Ile Phe Phe Xaa Leu 1 5 <210> SEQ ID NO 2420 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2420 Pro Ser Asp Phe Phe Pro Ser Val 1 5 <210> SEQ ID NO 2421 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2421 Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 <210> SEQ ID NO 2422 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide

<220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 9 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2422 Gln Leu Leu Trp Phe His Ile Ser Xaa Leu 1 5 10 <210> SEQ ID NO 2423 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2423 Gln Met Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 10 <210> SEQ ID NO 2424 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2424 Gln Val Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 10 <210> SEQ ID NO 2425 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2425 Arg Ile Pro Arg Thr Pro Arg Ser Val 1 5 <210> SEQ ID NO 2426 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.V9 <400> SEQUENCE: 2426 Arg Leu Ser Trp Pro Lys Phe Ala Val 1 5 <210> SEQ ID NO 2427 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.V9 <400> SEQUENCE: 2427 Arg Leu Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 2428 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide IM2.LV9 <400> SEQUENCE: 2428 Arg Met Leu Thr Ile Pro Gln Ser Val 1 5 <210> SEQ ID NO 2429 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VM2.V9 <400> SEQUENCE: 2429 Arg Met Thr Gly Gly Val Phe Leu Val 1 5 <210> SEQ ID NO 2430 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2430 Arg Met Tyr Leu His Thr Leu Trp Lys 1 5 <210> SEQ ID NO 2431 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2431 Arg Val Tyr Leu His Thr Leu Trp Lys 1 5 <210> SEQ ID NO 2432 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 4 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2432 Ser Ala Ile Xaa Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 2433 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2433 Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2434 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 11 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2434 Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 <210> SEQ ID NO 2435 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2435 Ser Leu Asp Ser Trp Trp Thr Ser Val 1 5 <210> SEQ ID NO 2436 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 10 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2436 Ser Leu Asn Phe Leu Gly Gly Thr Thr Xaa 1 5 10 <210> SEQ ID NO 2437 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2437 Ser Met Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 2438 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2438 Ser Met Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 2439 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2439 Ser Met Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2440 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide IM2.LV1 <400> SEQUENCE: 2440

Ser Met Leu Ser Pro Phe Leu Pro Leu Val 1 5 10 <210> SEQ ID NO 2441 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2441 Ser Pro Phe Leu Leu Ala Gln Ile 1 5 <210> SEQ ID NO 2442 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2442 Ser Thr Leu Pro Glu Thr Tyr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2443 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2443 Ser Val Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 2444 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2444 Ser Val Leu Pro Glu Thr Thr Val Val Arg 1 5 10 <210> SEQ ID NO 2445 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2445 Ser Val Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2446 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2446 Ser Val Asn Arg Pro Ile Asp Trp Lys 1 5 <210> SEQ ID NO 2447 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2447 Ser Val Val Arg Arg Ala Phe Pro Lys 1 5 <210> SEQ ID NO 2448 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2448 Ser Val Val Arg Arg Ala Phe Pro Arg 1 5 <210> SEQ ID NO 2449 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2449 Thr Leu Trp Lys Ala Gly Ile Leu Lys 1 5 <210> SEQ ID NO 2450 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2450 Thr Leu Trp Lys Ala Gly Ile Leu Arg 1 5 <210> SEQ ID NO 2451 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2451 Thr Met Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2452 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2452 Thr Met Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 2453 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2453 Thr Met Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 2454 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2454 Thr Pro Ala Arg Val Thr Gly Gly Val Ile 1 5 10 <210> SEQ ID NO 2455 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2455 Thr Pro Phe Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 2456 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <400> SEQUENCE: 2456 Thr Ser Ala Ile Xaa Ser Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2457 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 16 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2457 Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 15 <210> SEQ ID NO 2458 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2458 Thr Val Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2459 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:

<223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2459 Thr Val Trp Lys Ala Gly Ile Leu Tyr 1 5 <210> SEQ ID NO 2460 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2460 Thr Val Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 2461 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 15 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2461 Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Xaa 1 5 10 15 <210> SEQ ID NO 2462 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 10 <223> OTHER INFORMATION: Xaa=V-NH-2 <400> SEQUENCE: 2462 Val Leu Glu Tyr Leu Val Ser Phe Gly Xaa 1 5 10 <210> SEQ ID NO 2463 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2463 Val Leu Gly Gly Ser Arg His Lys Leu 1 5 <210> SEQ ID NO 2464 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2464 Val Leu Leu Asp Tyr Gln Gly Met Val 1 5 <210> SEQ ID NO 2465 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.LV9 <400> SEQUENCE: 2465 Val Leu Gln Ala Gly Phe Phe Leu Val 1 5 <210> SEQ ID NO 2466 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2466 Val Met Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 2467 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2467 Val Pro Phe Val Gln Trp Phe Val Gly Ile 1 5 10 <210> SEQ ID NO 2468 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2468 Val Pro Ser Ala Leu Asn Pro Ile 1 5 <210> SEQ ID NO 2469 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2469 Val Val Phe Phe Ser Gln Phe Ser Arg 1 5 <210> SEQ ID NO 2470 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2470 Val Val Gly Gly Val Phe Leu Val Asp Lys 1 5 10 <210> SEQ ID NO 2471 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide IL2.V9 <400> SEQUENCE: 2471 Trp Leu Leu Arg Gly Thr Ser Phe Val 1 5 <210> SEQ ID NO 2472 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: clostridium tetani <400> SEQUENCE: 2472 Tyr Leu Phe Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 2473 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide L2.IV10 <400> SEQUENCE: 2473 Tyr Leu His Thr Leu Trp Lys Ala Gly Val 1 5 10 <210> SEQ ID NO 2474 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2474 Tyr Leu Leu Thr Leu Trp Lys Ala Gly Ile 1 5 10 <210> SEQ ID NO 2475 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2475 Tyr Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 2476 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide VL2.AV9 <400> SEQUENCE: 2476 Tyr Leu Pro Ser Ala Leu Asn Pro Val 1 5 <210> SEQ ID NO 2477 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2477 Tyr Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2478 <211> LENGTH: 9 <212> TYPE: PRT

<213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide M2.AV9 <400> SEQUENCE: 2478 Tyr Met Asp Asp Val Val Leu Gly Val 1 5 <210> SEQ ID NO 2479 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2479 Tyr Met Phe Asp Val Val Leu Gly Ala 1 5 <210> SEQ ID NO 2480 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2480 Tyr Met Phe Asp Val Val Leu Gly Ala Lys 1 5 10 <210> SEQ ID NO 2481 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2481 Tyr Asn Met Gly Leu Lys Phe Arg Gln Leu 1 5 10 <210> SEQ ID NO 2482 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2482 Tyr Pro Ala Leu Met Pro Leu Ile 1 5 <210> SEQ ID NO 2483 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2483 Tyr Pro Ala Leu Met Pro Leu Tyr Ile 1 5 <210> SEQ ID NO 2484 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2484 Tyr Pro Phe Leu Met Pro Leu Tyr Ala 1 5 <210> SEQ ID NO 2485 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV analog peptide <400> SEQUENCE: 2485 Tyr Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2486 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*0101 <400> SEQUENCE: 2486 Tyr Leu Glu Pro Ala Ile Ala Lys Tyr 1 5 <210> SEQ ID NO 2487 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to multiple HLAs <400> SEQUENCE: 2487 Phe Leu Pro Ser Asp Tyr Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2488 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*6802 <400> SEQUENCE: 2488 Phe Thr Gln Ala Gly Tyr Pro Ala Leu 1 5 <210> SEQ ID NO 2489 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*0301, A*6801 <400> SEQUENCE: 2489 Lys Val Phe Pro Tyr Ala Leu Ile Asn Lys 1 5 10 <210> SEQ ID NO 2490 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*1101 <400> SEQUENCE: 2490 Ala Val Asp Leu Tyr His Phe Leu Lys 1 5 <210> SEQ ID NO 2491 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*3301 <400> SEQUENCE: 2491 Ser Thr Leu Pro Glu Thr Tyr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2492 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA A*2401 <400> SEQUENCE: 2492 Ala Tyr Ile Asp Asn Tyr Asn Lys Phe 1 5 <210> SEQ ID NO 2493 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA B*0702 <400> SEQUENCE: 2493 Ala Pro Arg Thr Leu Val Tyr Leu Leu 1 5 <210> SEQ ID NO 2494 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA B*3501, B51, B*5301, B*5401 <400> SEQUENCE: 2494 Phe Pro Phe Lys Tyr Ala Ala Ala Phe 1 5 <210> SEQ ID NO 2495 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*0101, DRB1*0401 <400> SEQUENCE: 2495 Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 1 5 10 <210> SEQ ID NO 2496 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*0301 <400> SEQUENCE: 2496 Tyr Lys Thr Ile Ala Phe Asp Glu Glu Ala Arg Arg 1 5 10

<210> SEQ ID NO 2497 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*0404, DRB1*0405 <400> SEQUENCE: 2497 Tyr Ala Arg Phe Gln Ser Gln Thr Thr Leu Lys Gln Lys Thr 1 5 10 <210> SEQ ID NO 2498 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to multiple HLA DRB1s <400> SEQUENCE: 2498 Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 1 5 10 <210> SEQ ID NO 2499 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*1201 <400> SEQUENCE: 2499 Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu Ser 1 5 10 15 <210> SEQ ID NO 2500 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*1302 <400> SEQUENCE: 2500 Gln Tyr Ile Lys Ala Asn Ala Lys Phe Ile Gly Ile Thr Glu 1 5 10 <210> SEQ ID NO 2501 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB1*1501 <400> SEQUENCE: 2501 Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile 1 5 10 15 Val Thr Pro Arg Thr Pro Pro Pro 20 <210> SEQ ID NO 2502 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB3*0101 <400> SEQUENCE: 2502 Asn Gly Gln Ile Gly Asn Asp Pro Asn Arg Asp Ile Leu 1 5 10 <210> SEQ ID NO 2503 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB4*0101 <400> SEQUENCE: 2503 Tyr Ala Arg Phe Gln Ser Gln Thr Thr Leu Lys Gln Lys Thr 1 5 10 <210> SEQ ID NO 2504 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic peptide that binds to HLA DRB5*0101 <400> SEQUENCE: 2504 Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 1 5 10 <210> SEQ ID NO 2505 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2505 Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2506 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV ENV 313 substitution peptide <400> SEQUENCE: 2506 Phe Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2507 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV ENV 313 substitution peptide <400> SEQUENCE: 2507 Ile Pro Ile Pro Ser Ser Trp Ala Ile 1 5 <210> SEQ ID NO 2508 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2508 Phe Pro His Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 2509 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV POL 541 substitution peptide <400> SEQUENCE: 2509 Phe Pro His Cys Leu Ala Phe Ala Leu 1 5 <210> SEQ ID NO 2510 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV POL 541 substitution peptide <400> SEQUENCE: 2510 Phe Pro His Cys Leu Ala Phe Ser Leu 1 5 <210> SEQ ID NO 2511 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV POL 541 substitution peptide <400> SEQUENCE: 2511 Phe Pro Phe Cys Leu Ala Phe Ser Tyr 1 5 <210> SEQ ID NO 2512 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV POL 541 substitution peptide <400> SEQUENCE: 2512 Phe Pro His Cys Leu Ala Phe Ser Ile 1 5 <210> SEQ ID NO 2513 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HBV POL 541 substitution peptide <400> SEQUENCE: 2513 Phe Pro His Cys Leu Ala Phe Ser Ala 1 5 <210> SEQ ID NO 2514 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis C virus <400> SEQUENCE: 2514 Leu Pro Gly Cys Ser Phe Ser Ile Phe 1 5 <210> SEQ ID NO 2515 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: HCV Core 168 substitution peptide <400> SEQUENCE: 2515

Phe Pro Gly Cys Ser Phe Ser Ile Phe 1 5 <210> SEQ ID NO 2516 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 2516 Val Pro Ile Ser His Leu Tyr Ile Leu 1 5 <210> SEQ ID NO 2517 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic MAGE2 170 substitution peptide <400> SEQUENCE: 2517 Phe Pro Ile Ser His Leu Tyr Ile Leu 1 5 <210> SEQ ID NO 2518 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 2518 Met Pro Lys Ala Gly Leu Leu Ile Ile 1 5 <210> SEQ ID NO 2519 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic MAGE3 196 substitution peptide <400> SEQUENCE: 2519 Phe Pro Lys Ala Gly Leu Leu Ile Ile 1 5 <210> SEQ ID NO 2520 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic MAGE3 196 substitution peptide <400> SEQUENCE: 2520 Met Pro Phe Ala Gly Leu Leu Ile Ile 1 5 <210> SEQ ID NO 2521 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2521 Phe Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 10 <210> SEQ ID NO 2522 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2522 Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 <210> SEQ ID NO 2523 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2523 Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 <210> SEQ ID NO 2524 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2524 Trp Leu Ser Leu Leu Val Pro Phe Val 1 5 <210> SEQ ID NO 2525 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2525 Tyr Met Asp Asp Val Val Leu Gly Ala 1 5 <210> SEQ ID NO 2526 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2526 Gly Leu Ser Arg Tyr Val Ala Arg Leu 1 5 <210> SEQ ID NO 2527 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2527 Phe Leu Leu Ser Leu Gly Ile His Leu 1 5 <210> SEQ ID NO 2528 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2528 Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 1 5 10 <210> SEQ ID NO 2529 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2529 Leu Leu Val Pro Phe Val Gln Trp Phe Val 1 5 10 <210> SEQ ID NO 2530 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2530 His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 <210> SEQ ID NO 2531 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2531 Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2532 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2532 Asn Val Ser Ile Pro Trp Thr His Lys 1 5 <210> SEQ ID NO 2533 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2533 Leu Val Val Asp Phe Ser Gln Phe Ser Arg 1 5 10 <210> SEQ ID NO 2534 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2534 Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys 1 5 10 <210> SEQ ID NO 2535 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2535 Ser Ala Ile Cys Ser Val Val Arg Arg 1 5 <210> SEQ ID NO 2536 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2536 Lys Val Gly Asn Phe Thr Gly Leu Tyr 1 5 <210> SEQ ID NO 2537 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2537 Phe Pro His Cys Leu Ala Phe Ser Tyr Met 1 5 10

<210> SEQ ID NO 2538 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2538 Leu Pro Ser Asp Phe Phe Pro Ser Val 1 5 <210> SEQ ID NO 2539 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2539 Ile Pro Ile Pro Ser Ser Trp Ala Phe 1 5 <210> SEQ ID NO 2540 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2540 His Pro Ala Ala Met Pro His Leu Leu 1 5 <210> SEQ ID NO 2541 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2541 Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile 1 5 10 <210> SEQ ID NO 2542 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2542 Thr Pro Ala Arg Val Thr Gly Gly Val Phe 1 5 10 <210> SEQ ID NO 2543 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2543 Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr 1 5 10 <210> SEQ ID NO 2544 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2544 Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr 1 5 10 <210> SEQ ID NO 2545 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2545 Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 1 5 10 <210> SEQ ID NO 2546 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2546 Arg Trp Met Cys Leu Arg Arg Phe Ile Ile 1 5 10 <210> SEQ ID NO 2547 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2547 Ser Trp Leu Ser Leu Leu Val Pro Phe 1 5 <210> SEQ ID NO 2548 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2548 Ser Trp Trp Thr Ser Leu Asn Phe Leu 1 5 <210> SEQ ID NO 2549 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2549 Glu Tyr Leu Val Ser Phe Gly Val Trp Ile 1 5 10 <210> SEQ ID NO 2550 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2550 Ala Tyr Arg Pro Pro Asn Ala Pro Ile 1 5 <210> SEQ ID NO 2551 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2551 Trp Phe His Ile Ser Cys Leu Thr Phe 1 5 <210> SEQ ID NO 2552 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2552 Ser Trp Pro Lys Phe Ala Val Pro Asn Leu 1 5 10 <210> SEQ ID NO 2553 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2553 Lys Tyr Thr Ser Phe Pro Trp Leu Leu 1 5 <210> SEQ ID NO 2554 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2554 Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 1 5 10 <210> SEQ ID NO 2555 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2555 Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu 1 5 10 15 <210> SEQ ID NO 2556 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2556 Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys 1 5 10 15 <210> SEQ ID NO 2557 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2557 Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser 1 5 10 15 <210> SEQ ID NO 2558 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2558 Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala Asp 1 5 10 15 <210> SEQ ID NO 2559 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2559 Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro 1 5 10 15 Asn Ala Pro Ile 20 <210> SEQ ID NO 2560 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus

<400> SEQUENCE: 2560 Arg His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 1 5 10 15 <210> SEQ ID NO 2561 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2561 Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val 1 5 10 15 <210> SEQ ID NO 2562 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2562 Leu His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys Ile 1 5 10 15 <210> SEQ ID NO 2563 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2563 Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val 1 5 10 15 <210> SEQ ID NO 2564 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2564 Lys Gln Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp 1 5 10 15 <210> SEQ ID NO 2565 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2565 Ala Ala Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val Pro 1 5 10 15 <210> SEQ ID NO 2566 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2566 Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu 1 5 10 15 Met Thr Leu Ala 20 <210> SEQ ID NO 2567 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2567 Leu Cys Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 1 5 10 15 <210> SEQ ID NO 2568 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2568 Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg Gly Asn 1 5 10 15 <210> SEQ ID NO 2569 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2569 Val Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Lys Leu Ile 1 5 10 15 <210> SEQ ID NO 2570 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2570 Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe 1 5 10 15 <210> SEQ ID NO 2571 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Orthohepadnaviridae hepatitis B virus <400> SEQUENCE: 2571 Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His 1 5 10 15 <210> SEQ ID NO 2572 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Clostridium tetani <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)...(14) <223> OTHER INFORMATION: tetanus toxoid positions 830-843 <400> SEQUENCE: 2572 Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 1 5 10 <210> SEQ ID NO 2573 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Plasmodium falciparum <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)...(21) <223> OTHER INFORMATION: CS protein positions 378-398 <400> SEQUENCE: 2573 Asp Ile Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe 1 5 10 15 Asn Val Val Asn Ser 20 <210> SEQ ID NO 2574 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Streptococcus sp. <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)...(16) <223> OTHER INFORMATION: 18kd protein position 116 <400> SEQUENCE: 2574 Gly Ala Val Asp Ser Ile Leu Gly Gly Val Ala Thr Tyr Gly Ala Ala 1 5 10 15 <210> SEQ ID NO 2575 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic pan-DR binding epitope peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 3 <223> OTHER INFORMATION: Xaa=cyclohexylalanine, phenylalanine, or tyrosine <400> SEQUENCE: 2575 Ala Lys Xaa Val Trp Ala Asn Thr Leu Lys Ala Ala Ala 1 5 10 <210> SEQ ID NO 2576 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Synthetic A3CON1 peptide <400> SEQUENCE: 2576 Lys Val Phe Pro Tyr Ala Leu Ile Asn Lys 1 5 10 <210> SEQ ID NO 2577 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: T7Y analogue of HBVc 141-151 <400> SEQUENCE: 2577 Ser Thr Leu Pro Glu Thr Tyr Val Val Arg Arg 1 5 10 <210> SEQ ID NO 2578 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic DR7 preferred motif <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 1 <223> OTHER INFORMATION: Xaa=Met, Phe, Leu, Ile, Val, Trp or Tyr <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Ile, Val, Met, Ser, Ala, Cys, Thr, Pro, Leu <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 8 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 9 <223> OTHER INFORMATION: Xaa=Ile or Val <400> SEQUENCE: 2578 Xaa Met Trp Ala Xaa Xaa Met Xaa Xaa

1 5 <210> SEQ ID NO 2579 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic DR7 deleterious motif <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 1 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 3 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 5 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 6 <223> OTHER INFORMATION: Xaa=Any amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION: 7 <223> OTHER INFORMATION: Xaa=Gly, Arg or Asp <400> SEQUENCE: 2579 Xaa Cys Xaa Gly Xaa Xaa Xaa Asn Gly 1 5

Claims

1. A peptide composition of less than 100 amino acid residues comprising a peptide epitope useful for inducing an immune response against hepatitis B virus (HBV) said epitope (a) having an amino acid sequence of about 8 to about 13 amino acid residues that have at least 65% identity with a native amino acid sequence for HBV, and, (b) binding to at least one MHC class I HLA allele with a dissociation constant of less than about 500 nM.

2. The composition of claim 1, further wherein said peptide has at least 77% identity with a native HBV amino acid sequence.

3. The composition of claim 1, further wherein said peptide has 100% identity with a native HBV amino acid sequence.

4. The composition of claim 1, further wherein said peptide is one of those peptides described in Tables VI-XVII or XXI.

5. The composition of claim 4, further wherein said peptide is one of the peptides designated as being from the envelope region of HBV.

6. The composition of claim 4, further wherein said peptide is one of the peptides designated as being from the polymerase region of HBV.

7. The composition of claim 4, further wherein said peptide is one of the peptides designated as being from the protein X region of HBV.

8. The composition of claim 4, further wherein said peptide is one of the peptides designated as being from the nucleocapsid core region of HBV.

9. A composition of less than 100 amino acid residues comprising a peptide epitope useful for inducing an immune response against hepatitis B virus (HBV) said peptide (a) having an amino acid sequence of about 8 to about 13 amino acid residues and (b) bearing one of the HLA motifs set out in Tables I and II.

10. The composition of claim 9, further wherein said peptide is one of those peptides described in Table VI or Table XXI bearing an HLA A1 supermotif.

11. The composition of claim 9, further wherein said peptide is one of those peptides described in Table VII or Table XXI bearing an HLA A2 supermotif.

12. The composition of claim 9, further wherein said peptide is one of those peptides described in Table VIII or Table XXI bearing an HLA A3 supermotif.

13. The composition of claim 9, further wherein said peptide is one of those peptides described in Table IX or Table XXI bearing an HLA A24 supermotif.

14. The composition of claim 9, further wherein said peptide is one of those peptides described in Table X or Table XXI bearing an HLA B7 supermotif.

15. The composition of claim 9, further wherein said peptide is one of those peptides described in Table XI bearing an HLA B27 supermotif.

16. The composition of claim 9, further wherein said peptide is one of those peptides described in Table XII bearing an HLA B44 supermotif.

17. The composition of claim 9, further wherein said peptide is one of those peptides described in Table XIII bearing an HLA B58 supermotif.

18. The composition of claim 9, further wherein said peptide is one of those peptides described in Table XIV bearing an HLA B62 supermotif.

19. The composition of claim 9, further wherein said peptide is one of those peptides described in Table XV bearing an HLA A1 motif.

20. The composition of claim 9, further wherein said peptide is one of those peptides described in Table XVI bearing an HLA A3 motif.

21. The composition of claim 9, further wherein said peptide is one of those peptides described in Table XVI bearing an HLA A11 motif.

22. The composition of claim 9, further wherein said peptide is one of those peptides described in Table XVII bearing an HLA A24 motif.

23. The composition of claim 9, further wherein said peptide is one of those peptides described in Table VII bearing an HLA A2.1 motif wherein the epitope is numbered from an amino terminal to carboxyl terminal orientation relative to the peptide, with the proviso that the peptide does not bear L or M at position 2 and V at C-terminal position 9 of a 9 amino acid peptide.

24. An analog of an HBV peptide of less than 100 amino acid residues in length that bears an HLA binding motif, the analog bearing the same HLA binding motif as the peptide but comprising at least one anchor residue that is different from that of the peptide.

25. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table VI bearing an HLA A1 supermotif.

26. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table VII bearing an HLA A2 supermotif.

27. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table VIII bearing an HLA A3 supermotif.

28. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table IX bearing an HLA A24 supermotif.

29. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table X bearing an HLA B7 supermotif.

30. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table XI bearing an HLA B27 supermotif.

31. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table XII bearing an HLA B44 supermotif.

32. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table XIII bearing an HLA B58 supermotif

33. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table XIV bearing an HLA B62 supermotif.

34. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table XV bearing an HLA A1 motif.

35. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table XVI bearing an HLA A3 motif.

36. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table XVI bearing an HLA A11 motif.

37. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table XVII bearing an HLA A24 motif.

38. The composition of claim 24, further wherein said peptide is an analog of a peptide described in Table VII bearing an HLA A2.1 motif.

39. The composition of claim 24, wherein said peptide is an analog of a peptide described in Table XVIII or Table XIX comprising at HLA class II motif.

40. A composition of less than 100 amino acid residues comprising a peptide epitope useful for inducing an immune response against hepatitis B virus (HBV) said peptide (a) having an amino acid sequence of about 9 to about 25 amino acid residues that have at least 65% identity with a native amino acid sequence for HBV and (b) binding to at least one MHC class II HLA allele with a dissociation constant of less than about 1000 nM.

41. The composition of claim 40, further wherein said peptide has at least 77% identity with a native HBV amino acid sequence.

42. The composition of claim 40, further wherein said peptide has 100% identity with a native HBV amino acid sequence.

43. The composition of claim 40, further wherein said peptide is one of those peptides described in Table XVIII or Table XIX.

44. A peptide composition of less than 100 amino acid residues, said composition comprising an epitope useful for inducing an immune response against hepatitis B virus (HBV) said epitope (a) having an amino acid sequence of about 9 to about 25 amino acid residues and (b) bearing one of the class II HLA motifs set out in Table III.

45. The composition of claim 44, further wherein said peptide is one of those peptides described in Table XVIII or XIX.

46. A composition that comprises an isolated nucleic acid sequence that encodes one of the peptides set out in Tables VI-XIX or XXI or XXIII.

47. A composition that comprises at least two peptides at least one of said at least two peptides selected from Tables VI-XIX or XXI or XXIII.

48. A composition of claim 47 wherein two or more of the at least two peptides are depicted in Tables VI-XIX or XXI or XXIII.

49. A composition that comprises at least one nucleic acid sequence, that encodes the peptides of claim 47.

50. The composition of claim 47 wherein each of said at least two peptides are encoded by a nucleic acid sequence, wherein each of the nucleic acid sequences are located on a single vector.

51. A peptide composition of less than 100 amino acid residues, said composition comprising an epitope useful for inducing an immune response against hepatitis B virus (HBV) said epitope having at least one of the amino acid sequences set out in Table XXIII.

52. A method for inducing a cytotoxic T cell response to HBV in a mammal comprising administering to said mammal at least one peptide from Tables VI to XIX or Table XXI.

53. A vaccine for treating HBV infection that induces a protective immune response, wherein said vaccine comprises at least one peptide selected from Tables VI to Table XIX or Table XXI in a pharmaceutically acceptable carrier.

54. A vaccine for preventing HBV infection that induces a protective immune response, wherein said vaccine comprises at least one peptide selected from Tables VI to XIX or Table XXI in a pharmaceutically acceptable carrier.

55. A method for inducing a cytotoxic T cell response to HBV in a mammal, comprising administering to said mammal a nucleic acid sequence encoding a peptide selected from Tables VI to XIX or Table XXI.

56. A kit for a vaccine for treating or preventing HBV infection, wherein the vaccine induces a protective immune response, said vaccine comprising at least one peptide selected from Tables VI to XIX or Table XXI in a pharmaceutically acceptable carrier and instructions for administration to a patient.

57. A method for monitoring an immune response to HBV or an epitope thereof in a patient having a known HLA-type, the method comprising incubating a T lymphocyte sample from the patient with a peptide selected from Tables VI to XIX or Table XXI, which peptide binds a motif corresponding to at least one HLA allele present in said patient, and detecting the presence of a T lymphocyte that recognizes the peptide.

58. The method of claim 57, wherein the peptide comprises a tetrameric complex.