U.S. patent application number 12/225111 was filed with the patent office on 2010-03-04 for novel isolated and purified strains of chikungunya virus and polynucleotides and polypetide sequences, diagnostic and immunogenical uses thereof. Invention is credited to Anne-Claire Brehin, Pierre Charneau, Philippe Despres, Valerie Marechal, Philippe Souque.
Application Number | 20100055105 12/225111 |
Document ID | / |
Family ID | 38481184 |
Filed Date | 2010-03-04 |
United States Patent Application | 20100055105 |
Kind Code | A1 |
Despres; Philippe ; et al. | March 4, 2010 |
The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.
Inventors: | Despres; Philippe; (La Garenne Colombes, FR) ; Brehin; Anne-Claire; (Paris, FR) ; Marechal; Valerie; (Villejuif, FR) ; Charneau; Pierre; (Paris, FR) ; Souque; Philippe; (Plaisir, FR) |
Correspondence Address: |
FINNEGAN, HENDERSON, FARABOW, GARRETT & DUNNER;LLP 901 NEW YORK AVENUE, NW WASHINGTON DC 20001-4413 US |
Family ID: | 38481184 |
Appl. No.: | 12/225111 |
Filed: | March 15, 2007 |
PCT Filed: | March 15, 2007 |
PCT NO: | PCT/IB2007/001716 |
371 Date: | September 29, 2009 |
Current U.S. Class: | 424/139.1 ; 424/93.6; 435/235.1; 435/320.1; 435/5; 514/1.1; 514/44R; 530/350; 530/387.9; 536/23.72 |
Current CPC Class: | G01N 2800/32 20130101; C12N 7/00 20130101; G01N 2333/181 20130101; Y02A 50/30 20180101; C12N 2770/36121 20130101; C12N 2770/36122 20130101; G01N 33/56983 20130101; A61K 38/00 20130101; Y02A 50/383 20180101; A61K 39/00 20130101; A61P 31/12 20180101; C12N 2770/36131 20130101; Y02A 50/51 20180101; C07K 14/005 20130101; C07K 16/1081 20130101 |
Class at Publication: | 424/139.1 ; 435/235.1; 536/23.72; 435/320.1; 530/350; 530/387.9; 435/5; 424/93.6; 514/44.R; 514/12 |
International Class: | A61K 39/395 20060101 A61K039/395; C12N 7/00 20060101 C12N007/00; C07H 21/04 20060101 C07H021/04; C12N 15/63 20060101 C12N015/63; C07K 14/005 20060101 C07K014/005; C07K 16/08 20060101 C07K016/08; C12Q 1/70 20060101 C12Q001/70; A61K 35/76 20060101 A61K035/76; A61K 31/7088 20060101 A61K031/7088; A61K 38/16 20060101 A61K038/16 |
Date | Code | Application Number |
---|---|---|
Mar 15, 2006 | CA | 2,538,898 |
Apr 4, 2006 | CA | 2,545,597 |
Sequence CWU 1
1
103111601DNAChikungunya virus 1caaagcaaga gattaataac ccatcatgga
tcctgtgtac gtggacatag acgctgacag 60cgcctttttg aaggccctgc aacgtgcgta
ccccatgttt gaggtggaac caaggcaggt 120cacaccgaat gaccatgcta
atgctagagc gttctcgcat ctagctataa aactaataga 180gcaggaaatt
gaccccgact caaccatcct ggatatcggc agtgcgccag caaggaggat
240gatgtcggac aggaagtacc actgcgtctg cccgatgcgc agtgcggaag
atcccgagag 300actcgccaat tatgcgagaa agctagcatc tgccgcagga
aaagtcctgg acagaaacat 360ctctggaaag atcggggact tacaagcagt
aatggccgtg ccagacacgg agacgccaac 420attctgctta cacacagacg
tctcatgtag acagagagca gacgtcgcta tataccaaga 480cgtctatgct
gtacacgcac ccacgtcgct ataccaccag gcgattaaag gggtccgagt
540ggcgtactgg gttgggttcg acacaacccc gttcatgtac aatgccatgg
cgggtgccta 600cccctcatac tcgacaaact gggcagatga gcaggtactg
aaggctaaga acataggatt 660atgttcaaca gacctgacgg aaggtagacg
aggcaagttg tctattatga gagggaaaaa 720gctaaaaccg tgcgaccgtg
tgctgttctc agtagggtca acgctctacc cggaaagccg 780caagctactt
aagagctggc acctgccatc ggtgttccat ttaaagggca aactcagctt
840cacatgccgc tgtgatacag tggtttcgtg tgagggctac gtcgttaaga
gaataacgat 900gagcccaggc ctttatggaa aaaccacagg gtatgcggta
acccaccacg cagacggatt 960cctgatgtgc aagactaccg acacggttga
cggcgaaaga gtgtcattct cggtgtgcac 1020atacgtgccg gcgaccattt
gtgatcaaat gaccggcatc cttgctacag aagtcacgcc 1080ggaggatgca
cagaagctgt tggtggggct gaaccagaga atagtggtta acggcagaac
1140gcaacggaat acgaacacca tgaaaaatta tctgcttccc gtggtcgccc
aagccttcag 1200taagtgggca aaggagtgcc ggaaagacat ggaagatgaa
aaactcctgg gggtcagaga 1260aagaacactg acctgctgct gtctatgggc
attcaagaag cagaaaacac acacggtcta 1320caagaggcct gatacccagt
caattcagaa ggttcaggcc gagtttgaca gctttgtggt 1380accgagtctg
tggtcgtccg ggttgtcaat ccctttgagg actagaatca aatggttgtt
1440aagcaaggtg ccaaaaaccg acctgatccc atacagcgga gacgcccgag
aagcccggga 1500cgcagaaaaa gaagcagagg aagaacgaga agcagaactg
actcgcgaag ccctaccacc 1560tctacaggca gcacaggaag atgttcaggt
cgaaatcgac gtggaacagc ttgaggacag 1620agcgggcgca ggaataatag
agactccgag aggagctatc aaagttactg cccaaccaac 1680agaccacgtc
gtgggagagt acctggtact ctccccgcag accgtactac gtagccagaa
1740gctcagtctg attcacgctt tggcggagca agtgaagacg tgcacgcaca
acggacgagc 1800agggaggtat gcggtcgaag cgtacgacgg ccgagtccta
gtgccctcag gctatgcaat 1860ctcgcctgaa gacttccaga gtctaagcga
aagcgcaacg atggtgtata acgaaagaga 1920gttcgtaaac agaaagctac
accatattgc gatgcacgga ccagccctga acaccgacga 1980agagtcgtat
gagctggtga gggcagagag gacagaacac gagtacgtct acgacgtgga
2040tcagagaaga tgctgtaaga aggaagaagc cgcaggactg gtactggtgg
gcgacttgac 2100taatccgccc taccacgaat tcgcatatga agggctaaaa
atccgccctg cctgcccata 2160caaaattgca gtcataggag tcttcggagt
accgggatct ggcaagtcag ctattatcaa 2220gaacctagtt accaggcagg
acctggtgac tagcggaaag aaagaaaact gccaagaaat 2280caccaccgac
gtgatgagac agagaggtct agagatatct gcacgtacgg ttgactcgct
2340gctcttgaat ggatgcaaca gaccagtcga cgtgttgtac gtagacgagg
cgtttgcgtg 2400ccactctgga acgctacttg ctttgatcgc cttggtgaga
ccaaggcaga aagttgtact 2460ttgtggtgac ccgaagcagt gcggcttctt
caatatgatg cagatgaaag tcaactataa 2520tcacaacatc tgcacccaag
tgtaccacaa aagtatctcc aggcggtgta cactgcctgt 2580gaccgccatt
gtgtcatcgt tgcattacga aggcaaaatg cgcactacga atgagtacaa
2640caagccgatt gtagtggaca ctacaggctc aacaaaacct gaccctggag
acctcgtgtt 2700aacgtgcttc agagggtggg ttaaacaact gcaaattgac
tatcgtggat acgaggtcat 2760gacagcagcc gcatcccaag ggttaaccag
aaaaggagtt tacgcagtta gacaaaaagt 2820taatgaaaac ccgctctatg
catcaacgtc agagcacgtc aacgtactcc taacgcgtac 2880ggaaggtaaa
ctggtatgga agacactttc cggcgacccg tggataaaga cgctgcagaa
2940cccaccgaaa ggaaacttca aagcaactat taaggagtgg gaggtggagc
atgcatcaat 3000aatggcgggc atctgcagtc accaaatgac cttcgataca
ttccaaaata aagccaacgt 3060ttgttgggct aagagcttgg tccctatcct
cgaaacagcg gggataaaac taaatgatag 3120gcagtggtct cagataattc
aagccttcaa agaagacaaa gcatactcac ctgaagtagc 3180cctgaatgaa
atatgtacgc gcatgtatgg ggtggatcta gacagcgggc tattttctaa
3240accgttggtg tctgtgtatt acgcggataa ccactgggat aataggcctg
gagggaaaat 3300gttcggattt aaccccgagg cagcatccat tctagaaaga
aagtatccat tcacaaaagg 3360gaagtggaac atcaacaagc agatctgcgt
gactaccagg aggatagaag actttaaccc 3420taccaccaac atcataccgg
ccaacaggag actaccacac tcattagtgg ccgaacaccg 3480cccagtaaaa
ggggaaagaa tggaatggct ggttaacaag ataaacggcc accacgtgct
3540cctggtcagt ggctataacc ttgcactgcc tactaagaga gtcacttggg
tagcgccgtt 3600aggtgtccgc ggagcggact acacatacaa cctagagttg
ggtctgccag caacgcttgg 3660taggtatgac ctagtggtca taaacatcca
cacacctttt cgcatacacc attaccaaca 3720gtgcgtcgac cacgcaatga
aactgcaaat gctcgggggt gactcattga gactgctcaa 3780accgggcggc
tctctattga tcagagcata tggttacgca gatagaacca gtgaacgagt
3840catctgcgta ttgggacgca agtttagatc gtctagagcg ttgaaaccac
catgtgtcac 3900cagcaacact gagatgtttt tcctattcag caactttgac
aatggcagaa ggaatttcac 3960aactcatgtc atgaacaatc aactgaatgc
agccttcgta ggacaggtca cccgagcagg 4020atgtgcaccg tcgtaccggg
taaaacgcat ggacatcgcg aagaacgatg aagagtgcgt 4080agtcaacgcc
gctaaccctc gcgggttacc gggtgacggt gtttgcaagg cagtatacaa
4140aaaatggccg gagtccttta agaacagtgc aacaccagtg ggaaccgcaa
aaacagttat 4200gtgcggtacg tatccagtaa tccacgctgt tggaccaaac
ttctctaatt attcggagtc 4260tgaaggggac cgggaattgg cagctgccta
tcgagaagtc gcaaaggaag taactaggct 4320gggagtaaat agtgtagcta
tacctctcct ctccacaggt gtatactcag gagggaaaga 4380caggctgacc
cagtcactga accacctctt tacagccatg gactcgacgg atgcagacgt
4440ggtcatctac tgccgcgaca aagaatggga gaagaaaata tctgaggcca
tacagatgcg 4500gacccaagta gagctgctgg atgagcacat ctccatagac
tgcgatattg ttcgcgtgca 4560ccctgacagc agcttggcag gcagaaaagg
atacagcacc acggaaggcg cactgtactc 4620atatctagaa gggacccgtt
ttcatcagac ggctgtggat atggcggaga tacatactat 4680gtggccaaag
caaacagagg ccaatgagca agtctgccta tatgccctgg gggaaagtat
4740tgaatcgatc aggcagaaat gcccggtgga tgatgcagac gcatcatctc
cccccaaaac 4800tgtcccgtgc ctttgccgtt acgctatgac tccagaacgc
gtcacccggc ttcgcatgaa 4860ccacgtcaca agcataattg tgtgttcttc
gtttcccctc ccaaagtaca aaatagaagg 4920agtgcaaaaa gtcaaatgct
ctaaggtaat gctatttgac cacaacgtgc catcgcgcgt 4980aagtccaagg
gaatatagat cttcccagga gtctgcacag gaggcgagta caatcacgtc
5040actgacgcat agtcaattcg acctaagcgt tgatggcgag atactgcccg
tcccgtcaga 5100cctggatgct gacgccccag ccctagaacc agcactagac
gacggggcga cacacacgct 5160gccatccaca accggaaacc ttgcggccgt
gtctgattgg gtaatgagca ccgtacctgt 5220cgcgccgccc agaagaaggc
gagggagaaa cctgactgtg acatgtgacg agagagaagg 5280gaatataaca
cccatggcta gcgtccgatt ctttagggca gagctgtgtc cggtcgtaca
5340agaaacagcg gagacgcgtg acacagcaat gtctcttcag gcaccaccga
gtaccgccac 5400ggaaccgaat catccgccga tctccttcgg agcatcaagc
gagacgttcc ccattacatt 5460tggggacttc aacgaaggag aaatcgaaag
cttgtcttct gagctactaa ctttcggaga 5520cttcttacca ggagaagtgg
atgacttgac agacagcgac tggtccacgt gctcagacac 5580ggacgacgag
ttatgactag acagggcagg tgggtatata ttctcgtcgg acaccggtcc
5640aggtcattta caacagaagt cagtacgcca gtcagtgctg ccggtgaaca
ccctggagga 5700agtccacgag gagaagtgtt acccacctaa gctggatgaa
gcaaaggagc aactattact 5760taagaaactc caggagagtg catccatggc
caacagaagc aggtatcagt cgcgcaaagt 5820agaaaacatg aaagcagcaa
tcatccagag actaaagaga ggctgtagac tatacttaat 5880gtcagagacc
ccaaaagtcc ctacttaccg gactacatat ccggcgcctg tgtactcgcc
5940tccgatcaac gtccgattgt ccaatcccga gtccgcagtg gcagcatgca
atgagttctt 6000agctagaaac tatccaactg tctcatcata ccaaattacc
gacgagtatg atgcatatct 6060agacatggtg gacgggtcgg agagttgcct
ggaccgagcg acattcaatc cgtcaaaact 6120caggagctac ccgaaacagc
acgcttacca cgcgccctcc atcagaagcg ctgtaccgtc 6180cccattccag
aacacactac agaatgtact ggcagcagcc acgaaaagaa actgcaacgt
6240cacacagatg agggaattac ccactttgga ctcagcagta ttcaacgtgg
agtgtttcaa 6300aaaattcgca tgcaaccaag aatactggga agaatttgct
gccagcccta ttaggataac 6360aactgagaat ttagcaacct atgttactaa
actaaaaggg ccaaaagcag cagcgctatt 6420cgcaaaaacc cataatctac
tgccactaca ggaagtacca atggataggt tcacagtaga 6480tatgaaaagg
gacgtgaagg tgactcctgg tacaaagcat acagaggaaa gacctaaggt
6540gcaggttata caggcggctg aacccttggc gacagcatac ctatgtggga
ttcacagaga 6600gctggttagg aggctgaacg ccgtcctcct acccaatgta
catacactat ttgacatgtc 6660tgccgaggat ttcgatgcca tcatagccgc
acactttaag ccaggagaca ctgttttgga 6720aacggacata gcctcctttg
ataagagcca agatgattca cttgcgctta ctgctttgat 6780gctgttagag
gatttagggg tggatcactc cctgctggac ttgatagagg ctgctttcgg
6840agagatttcc agctgtcacc taccgacagg tacgcgcttc aagttcggcg
ccatgatgaa 6900atcaggtatg ttcctaactc tgttcgtcaa cacattgtta
aacatcacca tcgccagccg 6960agtgctggaa gatcgtctga caaaatccgc
gtgcgcggcc ttcatcggcg acgacaacat 7020aatacatgga gtcgtctccg
atgaattgat ggcagccaga tgtgccactt ggatgaacat 7080ggaagtgaag
atcatagatg cagttgtatc cttgaaagcc ccttactttt gtggagggtt
7140tatactgcac gatactgtga caggaacagc ttgcagagtg gcagacccgc
taaaaaggct 7200ttttaaactg ggcaaaccgc tagcggcagg tgacgaacaa
gatgaagata gaagacgagc 7260gctggctgac gaagtgatca gatggcaacg
aacagggcta attgatgagc tggagaaagc 7320ggtatactct aggtacgaag
tgcagggtat atcagttgtg gtaatgtcca tggccacctt 7380tgcaagctcc
agatccaact tcgagaagct cagaggaccc gtcataactt tgtacggcgg
7440tcctaaatag gtacgcacta cagctaccta ttttgcagaa gccgacagca
agtatctaaa 7500cactaatcag ctacaatgga gttcatccca acccaaactt
tttacaatag gaggtaccag 7560cctcgaccct ggactccgcg ccctactatc
caagtcatca ggcccagacc gcgccctcag 7620aggcaagctg ggcaacttgc
ccagctgatc tcagcagtta ataaactgac aatgcgcgcg 7680gtaccccaac
agaagccacg caggaatcgg aagaataaga agcaaaagca aaaacaacag
7740gcgccacaaa acaacacaaa tcaaaagaag cagccaccta aaaagaaacc
ggctcaaaag 7800aaaaagaagc cgggccgcag agagaggatg tgcatgaaaa
tcgaaaatga ttgtattttc 7860gaagtcaagc acgaaggtaa ggtaacaggt
tacgcgtgcc tggtggggga caaagtaatg 7920aaaccagcac acgtaaaggg
gaccatcgat aacgcggacc tggccaaact ggcctttaag 7980cggtcatcta
agtatgacct tgaatgcgcg cagatacccg tgcacatgaa gtccgacgct
8040tcgaagttca cccatgagaa accggagggg tactacaact ggcaccacgg
agcagtacag 8100tactcaggag gccggttcac catccctaca ggtgctggca
aaccagggga cagcggcaga 8160ccgatcttcg acaacaaggg acgcgtggtg
gccatagtct taggaggagc taatgaagga 8220gcccgtacag ccctctcggt
ggtgacctgg aataaagaca ttgtcactaa aatcaccccc 8280gagggggccg
aagagtggag tcttgccatc ccagttatgt gcctgttggc aaacaccacg
8340ttcccctgct cccagccccc ttgcacgccc tgctgctacg aaaaggaacc
ggaggaaacc 8400ctacgcatgc ttgaggacaa cgtcatgaga cctgggtact
atcagctgct acaagcatcc 8460ttaacatgtt ctccccaccg ccagcgacgc
agcaccaagg acaacttcaa tgtctataaa 8520gccacaagac catacttagc
tcactgtccc gactgtggag aagggcactc gtgccatagt 8580cccgtagcac
tagaacgcat cagaaatgaa gcgacagacg ggacgctgaa aatccaggtc
8640tccttgcaaa tcggaataaa gacggatgac agccacgatt ggaccaagct
gcgttatatg 8700gacaaccaca tgccagcaga cgcagagagg gcggggctat
ttgtaagaac atcagcaccg 8760tgtacgatta ctggaacaat gggacacttc
atcctggccc gatgtccaaa aggggaaact 8820ctgacggtgg gattcactga
cagtaggaag attagtcact catgtacgca cccatttcac 8880cacgaccctc
ctgtgatagg tcgggaaaaa ttccattccc gaccgcagca cggtaaagag
8940ctaccttgca gcacgtacgt gcagagcacc gccgcaacta ccgaggagat
agaggtacac 9000atgcccccag acacccctga tcgcacatta atgtcacaac
agtccggcaa cgtaaagatc 9060acagtcaatg gccagacggt gcggtacaag
tgtaattgcg gtggctcaaa tgaaggacta 9120acaactacag acaaagtgat
taataactgc aaggttgatc aatgtcatgc cgcggtcacc 9180aatcacaaaa
agtggcagta taactcccct ctggtcccgc gtaatgctga acttggggac
9240cgaaaaggaa aaattcacat cccgtttccg ctggcaaatg taacatgcag
ggtgcctaaa 9300gcaaggaacc ccaccgtgac gtacgggaaa aaccaagtca
tcatgctact gtatcctgac 9360cacccaacac tcctgtccta ccggaatatg
ggagaagaac caaactatca agaagagtgg 9420gtgatgcata agaaggaagt
cgtgctaacc gtgccgactg aagggctcga ggtcacgtgg 9480ggcaacaacg
agccgtataa gtattggccg cagttatcta caaacggtac agcccatggc
9540cacccgcatg agataattct gtattattat gagctgtacc ccactatgac
tgtagtagtt 9600gtgtcagtgg ccacgttcat actcctgtcg atggtgggta
tggcagcggg gatgtgcatg 9660tgtgcacgac gcagatgcat cacaccgtat
gaactgacac caggagctac cgtccctttc 9720ctgcttagcc taatatgctg
catcagaaca gctaaagcgg ccacatacca agaggctgcg 9780atatacctgt
ggaacgagca gcaacctttg ttttggctac aagcccttat tccgctggca
9840gccctgattg ttctatgcaa ctgtctgaga ctcttaccat gctgctgtaa
aacgttggct 9900tttttagccg taatgagcgt cggtgcccac actgtgagcg
cgtacgaaca cgtaacagtg 9960atcccgaaca cggtgggagt accgtataag
actctagtca atagacctgg ctacagcccc 10020atggtattgg agatggaact
actgtcagtc actttggagc caacactatc gcttgattac 10080atcacgtgcg
agtacaaaac cgtcatcccg tctccgtacg tgaagtgctg cggtacagca
10140gagtgcaagg acaaaaacct acctgactac agctgtaagg tcttcaccgg
cgtctaccca 10200tttatgtggg gcggcgccta ctgcttctgc gacgctgaaa
acacgcagtt gagcgaagca 10260cacgtggaga agtccgaatc atgcaaaaca
gaatttgcat cagcatacag ggctcatacc 10320gcatctgcat cagctaagct
ccgcgtcctt taccaaggaa ataacatcac tgtaactgcc 10380tatgcaaacg
gcgaccatgc cgtcacagtt aaggacgcca aattcattgt ggggccaatg
10440tcttcagcct ggacaccttt cgacaacaaa attgtggtgt acaaaggtga
cgtctataac 10500atggactacc cgccctttgg cgcaggaaga ccaggacaat
ttggcgatat ccaaagtcgc 10560acacctgaga gtaaagacgt ctatgctaat
acacaactgg tactgcagag accggctgcg 10620ggtacggtac acgtgccata
ctctcaggca ccatctggct ttaagtattg gctaaaagaa 10680cgcggggcgt
cgctgcagca cacagcacca tttggctgcc aaatagcaac aaacccggta
10740agagcggtga actgcgccgt agggaacatg cccatctcca tcgacatacc
ggaagcggcc 10800ttcactaggg tcgtcgacgc gccctcttta acggacatgt
cgtgcgaggt accagcctgc 10860acccattcct cagactttgg gggcgtcgcc
attattaaat atgcagccag caagaaaggc 10920aagtgtgcgg tgcattcgat
gactaacgcc gtcactattc gggaagctga gatagaagtt 10980gaagggaatt
ctcagctgca aatctctttc tcgacggcct tagccagcgc cgaattccgc
11040gtacaagtct gttctacaca agtacactgt gcagccgagt gccacccccc
gaaggaccac 11100atagtcaact acccggcgtc acataccacc ctcggggtcc
aggacatctc cgctacggcg 11160atgtcatggg tgcagaagat cacgggaggt
gtgggactgg ttgttgctgt tgccgcactg 11220attctaatcg tggtgctatg
cgtgtcgttc agcaggcact aacttgacaa ttaagtatga 11280aggtatatgt
gtcccctaag agacacactg tacatagcaa ataatctata gatcaaaggg
11340ctacgcaacc cctgaatagt aacaaaatac aaaatcacta aaaattataa
aaacagaaaa 11400atacataaat aggtatacgt gtcccctaag agacacattg
tatgtaggtg ataagtatag 11460atcaaagggc cgaataaccc ctgaatagta
acaaaatatg aaaatcaata aaaatcataa 11520aatagaaaaa ccataaacag
aagtagttca aagggctata aaacccctga atagtaacaa 11580aacataaaat
taataaaaat c 11601211601DNAChikungunya virus 2caaagcaaga gattaataac
ccatcatgga tcctgtgtac gtggacatag acgctgacag 60cgcctttttg aaggccctgc
aacgtgcgta ccccatgttt gaggtggaac caaggcaggt 120cacaccgaat
gaccatgcta atgctagagc gttctcgcat ctagctataa aactaataga
180gcaggaaatt gaccccgact caaccatcct ggatatcggc agtgcgccag
caaggaggat 240gatgtcggac aggaagtacc actgcgtctg cccgatgcgc
agtgcggaag atcccgagag 300actcgccaat tatgcgagaa agctagcatc
tgccgcagga aaagtcctgg acagaaacat 360ctctggaaag atcggggact
tacaagcagt aatggccgtg ccagacacgg agacgccaac 420attctgctta
cacacagacg tctcatgtag acagagagca gacgtcgcta tataccaaga
480cgtctatgct gtacacgcac ccacgtcgct ataccaccag gcgattaaag
gggtccgagt 540ggcgtactgg gttgggttcg acacaacccc gttcatgtac
aatgccatgg cgggtgccta 600cccctcatac tcgacaaact gggcagatga
gcaggtactg aaggctaaga acataggatt 660atgttcaaca gacctgacgg
aaggtagacg aggcaagttg tctattatga gagggaaaaa 720gctaaaaccg
tgcgaccgtg tgctgttctc agtagggtca acgctctacc cggaaagccg
780caagctactt aagagctggc acctgccatc ggtgttccat ttaaagggca
aactcagctt 840cacatgccgc tgtgatacag tggtttcgtg tgagggctac
gtcgttaaga gaataacgat 900gagcccaggc ctttatggaa aaaccacagg
gtatgcggta acccaccacg cagacggatt 960cctgatgtgc aagactaccg
acacggttga cggcgaaaga gtgtcattct cggtgtgcac 1020atacgtgccg
gcgaccattt gtgatcaaat gaccggcatc cttgctacag aagtcacgcc
1080ggaggatgca cagaagctgt tggtggggct gaaccagaga atagtggtta
acggcagaac 1140gcaacggaat acgaacacca tgaaaaatta tctgcttccc
gtggtcgccc aagccttcag 1200taagtgggca aaggagtgcc ggaaagacat
ggaagatgaa aaactcctgg gggtcagaga 1260aagaacactg acctgctgct
gtctatgggc attcaagaag cagaaaacac acacggtcta 1320caagaggcct
gatacccagt caattcagaa ggttcaggcc gagtttgaca gctttgtggt
1380accgagtctg tggtcgtccg ggttgtcaat ccctttgagg actagaatca
aatggttgtt 1440aagcaaggtg ccaaaaaccg acctgatccc atacagcgga
gacgcccgag aagcccggga 1500cgcagaaaaa gaagcagagg aagaacgaga
agcagaactg actcgcgaag ccctaccacc 1560tctacaggca gcacaggaag
atgttcaggt cgaaatcgac gtggaacagc ttgaggacag 1620agcgggcgca
ggaataatag agactccgag aggagctatc aaagttactg cccaaccaac
1680agaccacgtc gtgggagagt acctggtact ctccccgcag accgtactac
gtagccagaa 1740gctcagtctg attcacgctt tggcggagca agtgaagacg
tgcacgcaca acggacgagc 1800agggaggtat gcggtcgaag cgtacgacgg
ccgagtccta gtgccctcag gctatgcaat 1860ctcgcctgaa gacttccaga
gtctaagcga aagcgcaacg atggtgtata acgaaagaga 1920gttcgtaaac
agaaagctac accatattgc gatgcacgga ccagccctga acaccgacga
1980agagtcgtat gagctggtga gggcagagag gacagaacac gagtacgtct
acgacgtgga 2040tcagagaaga tgctgtaaga aggaagaagc cgcaggactg
gtactggtgg gcgacttgac 2100taatccgccc taccacgaat tcgcatatga
agggctaaaa atccgccctg cctgcccata 2160caaaattgca gtcataggag
tcttcggagt accgggatct ggcaagtcag ctattatcaa 2220gaacctagtt
accaggcagg acctggtgac tagcggaaag aaagaaaact gccaagaaat
2280caccaccgac gtgatgagac agagaggtct agagatatct gcacgtacgg
ttgactcgct 2340gctcttgaat ggatgcaaca gaccagtcga cgtgttgtac
gtagacgagg cgtttgcgtg 2400ccactctgga acgctacttg ctttgatcgc
cttggtgaga ccaaggcaga aagttgtact 2460ttgtggtgac ccgaagcagt
gcggcttctt caatatgatg cagatgaaag tcaactataa 2520tcacaacatc
tgcacccaag tgtaccacaa aagtatctcc aggcggtgta cactgcctgt
2580gaccgccatt gtgtcatcgt tgcattacga aggcaaaatg cgcactacga
atgagtacaa 2640caagccgatt gtagtggaca ctacaggctc aacaaaacct
gaccctggag acctcgtgtt 2700aacgtgcttc agagggtggg ttaaacaact
gcaaattgac tatcgtggat acgaggtcat 2760gacagcagcc gcatcccaag
ggttaaccag aaaaggagtt tacgcagtta gacaaaaagt 2820taatgaaaac
ccgctctatg catcaacgtc agagcacgtc aacgtactcc taacgcgtac
2880ggaaggtaaa ctggtatgga agacactttc cggcgacccg tggataaaga
cgctgcagaa 2940cccaccgaaa ggaaacttca aagcaactat taaggagtgg
gaggtggagc atgcatcaat 3000aatggcgggc atctgcagtc accaaatgac
cttcgataca ttccaaaata aagccaacgt 3060ttgttgggct aagagcttgg
tccctatcct cgaaacagcg gggataaaac taaatgatag 3120gcagtggtct
cagataattc aagccttcaa agaagacaaa gcatactcac ctgaagtagc
3180cctgaatgaa atatgtacgc gcatgtatgg ggtggatcta gacagcgggc
tattttctaa 3240accgttggtg tctgtgtatt acgcggataa ccactgggat
aataggcctg gagggaaaat 3300gttcggattt aaccccgagg cagcatccat
tctagaaaga aagtatccat tcacaaaagg 3360gaagtggaac
atcaacaagc agatctgcgt gactaccagg aggatagaag actttaaccc
3420taccaccaac atcataccgg ccaacaggag actaccacac tcattagtgg
ccgaacaccg 3480cccagtaaaa ggggaaagaa tggaatggct ggttaacaag
ataaacggcc accacgtgct 3540cctggtcagt ggctataacc ttgcactgcc
tactaagaga gtcacttggg tagcgccgtt 3600aggtgtccgc ggagcggact
acacatacaa cctagagttg ggtctgccag caacgcttgg 3660taggtatgac
ctagtggtca taaacatcca cacacctttt cgcatacacc attaccaaca
3720gtgcgtcgac cacgcaatga aactgcaaat gctcgggggt gactcattga
gactgctcaa 3780accgggcggc tctctattga tcagagcata tggttacgca
gatagaacca gtgaacgagt 3840catctgcgta ttgggacgca agtttagatc
gtctagagcg ttgaaaccac catgtgtcac 3900cagcaacact gagatgtttt
tcctattcag caactttgac aatggcagaa ggaatttcac 3960aactcatgtc
atgaacaatc aactgaatgc agccttcgta ggacaggtca cccgagcagg
4020atgtgcaccg tcgtaccggg taaaacgcat ggacatcgcg aagaacgatg
aagagtgcgt 4080agtcaacgcc gctaaccctc gcgggttacc gggtgacggt
gtttgcaagg cagtatacaa 4140aaaatggccg gagtccttta agaacagtgc
aacaccagtg ggaaccgcaa aaacagttat 4200gtgcggtacg tatccagtaa
tccacgctgt tggaccaaac ttctctaatt attcggagtc 4260tgaaggggac
cgggaattgg cagctgccta tcgagaagtc gcaaaggaag taactaggct
4320gggagtaaat agtgtagcta tacctctcct ctccacaggt gtatactcag
gagggaaaga 4380caggctgacc cagtcactga accacctctt tacagccatg
gactcgacgg atgcagacgt 4440ggtcatctac tgccgcgaca aagaatggga
gaagaaaata tctgaggcca tacagatgcg 4500gacccaagta gagctgctgg
atgagcacat ctccatagac tgcgatattg ttcgcgtgca 4560ccctgacagc
agcttggcag gcagaaaagg atacagcacc acggaaggcg cactgtactc
4620atatctagaa gggacccgtt ttcatcagac ggctgtggat atggcggaga
tacatactat 4680gtggccaaag caaacagagg ccaatgagca agtctgccta
tatgccctgg gggaaagtat 4740tgaatcgatc aggcagaaat gcccggtgga
tgatgcagac gcatcatctc cccccaaaac 4800tgtcccgtgc ctttgccgtt
acgctatgac tccagaacgc gtcacccggc ttcgcatgaa 4860ccacgtcaca
agcataattg tgtgttcttc gtttcccctc ccaaagtaca aaatagaagg
4920agtgcaaaaa gtcaaatgct ctaaggtaat gctatttgac cacaacgtgc
catcgcgcgt 4980aagtccaagg gaatatagat cttcccagga gtctgcacag
gaggcgagta caatcacgtc 5040actgacgcat agtcaattcg acctaagcgt
tgatggcgag atactgcccg tcccgccaga 5100cctggatgct gacgccccag
ccctagaacc agcactagac gacggggcga cacacacgct 5160gccatccaca
accggaaacc ttgcggccgt gtctgattgg gtaatgagca ccgtacctgt
5220cgcgccgccc agaagaaggc gagggagaaa cctgactgtg acatgtgacg
agagagaagg 5280gaatataaca cccatggcta gcgtccgatt ctttagggca
gagctgtgtc cggtcgtaca 5340agaaacagcg gagacgcgtg acacagcaat
gtctcttcag gcaccaccga gtaccgccac 5400ggaaccgaat catccgccga
tctccttcgg agcatcaagc gagacgttcc ccattacatt 5460tggggacttc
aacgaaggag aaatcgaaag cttgtcttct gagctactaa ctttcggaga
5520cttcttacca ggagaagtgg atgacttgac agacagcgac tggtccacgt
gctcagacac 5580ggacgacgag ttatgactag acagggcagg tgggtatata
ttctcgtcgg acaccggtcc 5640aggtcattta caacagaagt cagtacgcca
gtcagtgctg ccggtgaaca ccctggagga 5700agtccacgag gagaagtgtt
acccacctaa gctggatgaa gcaaaggagc aactattact 5760taagaaactc
caggagagtg catccatggc caacagaagc aggtatcagt cgcgcaaagt
5820agaaaacatg aaagcagcaa tcatccagag actaaagaga ggctgtagac
tatacttaat 5880gtcagagacc ccaaaagtcc ctacttaccg gactacatat
ccggcgcctg tgtactcgcc 5940tccgatcaac gtccgattgt ccaatcccga
gtccgcagtg gcagcatgca atgagttctt 6000agctagaaac tatccaactg
tctcatcata ccaaattacc gacgagtatg atgcatatct 6060agacatggtg
gacgggtcgg agagttgcct ggaccgagcg acattcaatc cgtcaaaact
6120caggagctac ccgaaacagc acgcttacca cgcgccctcc atcagaagcg
ctgtaccgtc 6180cccattccag aacacactac agaatgtact ggcagcagcc
acgaaaagaa actgcaacgt 6240cacacagatg agggaattac ccactttgga
ctcagcagta ttcaacgtgg agtgtttcaa 6300aaaattcgca tgcaaccaag
aatactggga agaatttgct gccagcccta ttaggataac 6360aactgagaat
ttagcaacct atgttactaa actaaaaggg ccaaaagcag cagcgctatt
6420cgcaaaaacc cataatctac tgccactaca ggaagtacca atggataggt
tcacagtaga 6480tatgaaaagg gacgtgaagg tgactcctgg tacaaagcat
acagaggaaa gacctaaggt 6540gcaggttata caggcggctg aacccttggc
gacagcatac ctatgtggga ttcacagaga 6600gctggttagg aggctgaacg
ccgtcctcct acccaatgta catacactat ttgacatgtc 6660tgccgaggat
ttcgatgcca tcatagccgc acactttaag ccaggagaca ctgttttgga
6720aacggacata gcctcctttg ataagagcca agatgattca cttgcgctta
ctgctttgat 6780gctgttagag gatttagggg tggatcactc cctgctggac
ttgatagagg ctgctttcgg 6840agagatttcc agctgtcacc taccgacagg
tacgcgcttc aagttcggcg ccatgatgaa 6900atcaggtatg ttcctaactc
tgttcgtcaa cacattgtta aacatcacca tcgccagccg 6960agtgctggaa
gatcgtctga caaaatccgc gtgtgcggcc ttcatcggcg acgacaacat
7020aatacatgga gtcgtctccg atgaattgat ggcagccaga tgtgccactt
ggatgaacat 7080ggaagtgaag atcatagatg cagttgtatc cttgaaagcc
ccttactttt gtggagggtt 7140tatactgcac gatactgtga caggaacagc
ttgcagagtg gcagacccgc taaaaaggct 7200ttttaaactg ggcaaaccgc
tagcggcagg tgacgaacaa gatgaagata gaagacgagc 7260gctggctgac
gaagtgatca gatggcaacg aacagggcta attgatgagc tggagaaagc
7320ggtatactct aggtacgaag tgcagggtat atcagttgtg gtaatgtcca
tggccacctt 7380tgcaagctcc agatccaact tcgagaagct cagaggaccc
gtcataactt tgtacggcgg 7440tcctaaatag gtacgcacta cagctaccta
ttttgcagaa gccgacagca agtatctaaa 7500cactaatcag ctacaatgga
gttcatccca acccaaactt tttacaatag gaggtaccag 7560cctcgaccct
ggactccgcg ccctactatc caagtcatca ggcccagacc gcgccctcag
7620aggcaagctg ggcaacttgc ccagctgatc tcagcagtta ataaactgac
aatgcgcgcg 7680gtaccccaac agaagccacg caggaatcgg aagaataaga
agcaaaagca aaaacaacag 7740gcgccacaaa acaacacaaa tcaaaagaag
cagccaccta aaaagaaacc ggctcaaaag 7800aaaaagaagc cgggccgcag
agagaggatg tgcatgaaaa tcgaaaatga ttgtattttc 7860gaagtcaagc
acgaaggtaa ggtaacaggt tacgcgtgcc tggtggggga caaagtaatg
7920aaaccagcac acgtaaaggg gaccatcgat aacgcggacc tggccaaact
ggcctttaag 7980cggtcatcta agtatgacct tgaatgcgcg cagatacccg
tgcacatgaa gtccgacgct 8040tcgaagttca cccatgagaa accggagggg
tactacaact ggcaccacgg agcagtacag 8100tactcaggag gccggttcac
catccctaca ggtgctggca aaccagggga cagcggcaga 8160ccgatcttcg
acaacaaggg acgcgtggtg gccatagtct taggaggagc taatgaagga
8220gcccgtacag ccctctcggt ggtgacctgg aataaagaca ttgtcactaa
aatcaccccc 8280gagggggccg aagagtggag tcttgccatc ccagttatgt
gcctgttggc aaacaccacg 8340ttcccctgct cccagccccc ttgcacgccc
tgctgctacg aaaaggaacc ggaggaaacc 8400ctacgcatgc ttgaggacaa
cgtcatgaga cctgggtact atcagctgct acaagcatcc 8460ttaacatgtt
ctccccaccg ccagcgacgc agcaccaagg acaacttcaa tgtctataaa
8520gccacaagac catacttagc tcactgtccc gactgtggag aagggcactc
gtgccatagt 8580cccgtagcac tagaacgcat cagaaatgaa gcgacagacg
ggacgctgaa aatccaggtc 8640tccttgcaaa tcggaataaa gacggatgac
agccacgatt ggaccaagct gcgttatatg 8700gacaaccaca tgccagcaga
cgcagagagg gcggggctat ttgtaagaac atcagcaccg 8760tgtacgatta
ctggaacaat gggacacttc atcctggccc gatgtccaaa aggggaaact
8820ctgacggtgg gattcactga cagtaggaag attagtcact catgtacgca
cccatttcac 8880cacgaccctc ctgtgatagg tcgggaaaaa ttccattccc
gaccgcggca cggtaaagag 8940ctaccttgca gcacgtacgt gcagagcacc
gccgcaacta ccgaggagat agaggtacac 9000atgcccccag acacccctga
tcgcacatta atgtcacaac agtccggcaa cgtaaagatc 9060acagtcaatg
gccagacggt gcggtacaag tgtaattgcg gtggctcaaa tgaaggacta
9120acaactacag acaaagtgat taataactgc aaggttgatc aatgtcatgc
cgcggtcacc 9180aatcacaaaa agtggcagta taactcccct ctggtcccgc
gtaatgctga acttggggac 9240cgaaaaggaa aaattcacat cccgtttccg
ctggcaaatg taacatgcag ggtgcctaaa 9300gcaaggaacc ccaccgtgac
gtacgggaaa aaccaagtca tcatgctact gtatcctgac 9360cacccaacac
tcctgtccta ccggaatatg ggagaagaac caaactatca agaagagtgg
9420gtgatgcata agaaggaagt cgtgctaacc gtgccgactg aagggctcga
ggtcacgtgg 9480ggcaacaacg agccgtataa gtattggccg cagttatcta
caaacggtac agcccatggc 9540cacccgcatg agataattct gtattattat
gagctgtacc ccactatgac tgtagtagtt 9600gtgtcagtgg ccacgttcat
actcctgtcg atggtgggta tggcagcggg gatgtgcatg 9660tgtgcacgac
gcagatgcat cacaccgtat gaactgacac caggagctac cgtccctttc
9720ctgcttagcc taatatgctg catcagaaca gctaaagcgg ccacatacca
agaggctgcg 9780atatacctgt ggaacgagca gcaacctttg ttttggctac
aagcccttat tccgctggca 9840gccctgattg ttctatgcaa ctgtctgaga
ctcttaccat gctgctgtaa aacgttggct 9900tttttagccg taatgagcgt
cggtgcccac actgtgagcg cgtacgaaca cgtaacagtg 9960atcccgaaca
cggtgggagt accgtataag actctagtca atagacctgg ctacagcccc
10020atggtattgg agatggaact actgtcagtc actttggagc caacactatc
gcttgattac 10080atcacgtgcg agtacaaaac cgtcatcccg tctccgtacg
tgaagtgctg cggtacagca 10140gagtgcaagg acaaaaacct acctgactac
agctgtaagg tcttcaccgg cgtctaccca 10200tttatgtggg gcggcgccta
ctgcttctgc gacgctgaaa acacgcagtt gagcgaagca 10260cacgtggaga
agtccgaatc atgcaaaaca gaatttgcat cagcatacag ggctcatacc
10320gcatctgcat cagctaagct ccgcgtcctt taccaaggaa ataacatcac
tgtaactgcc 10380tatgcaaacg gcgaccatgc cgtcacagtt aaggacgcca
aattcattgt ggggccaatg 10440tcttcagcct ggacaccttt cgacaacaaa
attgtggtgt acaaaggtga cgtctataac 10500atggactacc cgccctttgg
cgcaggaaga ccaggacaat ttggcgatat ccaaagtcgc 10560acacctgaga
gtaaagacgt ctatgctaat acacaactgg tactgcagag accggctgcg
10620ggtacggtac acgtgccata ctctcaggca ccatctggct ttaagtattg
gctaaaagaa 10680cgcggggcgt cgctgcagca cacagcacca tttggctgcc
aaatagcaac aaacccggta 10740agagcggtga actgcgccgt agggaacatg
cccatctcca tcgacatacc ggaagcggcc 10800ttcactaggg tcgtcgacgc
gccctcttta acggacatgt cgtgcgaggt accagcctgc 10860acccattcct
cagactttgg gggcgtcgcc attattaaat atgcagccag caagaaaggc
10920aagtgtgcgg tgcattcgat gactaacgcc gtcactattc gggaagctga
gatagaagtt 10980gaagggaatt ctcagctgca aatctctttc tcgacggcct
tagccagcgc cgaattccgc 11040gtacaagtct gttctacaca agtacactgt
gcagccgagt gccacccccc gaaggaccac 11100atagtcaact acccggcgtc
acataccacc ctcggggtcc aggacatctc cgctacggcg 11160atgtcatggg
tgcagaagat cacgggaggt gtgggactgg ttgttgctgt tgccgcactg
11220attctaatcg tggtgctatg cgtatcgttc agcaggcact aacttgacaa
ttaagtatga 11280aggtatatgt gtcccctaag agacacactg tacatagcaa
ataatctata gatcaaaggg 11340ctacgcaacc cctgaatagt aacaaaatac
aaaatcacta aaaattataa aaacagaaaa 11400atacataaat aggtatacgt
gtcccctaag agacacattg tatgtaggtg ataagtatag 11460atcaaagggc
cgaataaccc ctgaatagta acaaaatatg aaaatcaata aaaatcataa
11520aatagaaaaa ccataaacag aagtagttca aagggctata aaacccctga
atagtaacaa 11580aacataaaat taataaaaat c 11601311601DNAChikungunya
virus 3caaagcaaga gattaataac ccatcatgga tcctgtgtac gtggacatag
acgctgacag 60cgcctttttg aaggccctgc aacgtgcgta ccccatgttt gaggtggaac
caaggcaggt 120cacaccgaat gaccatgcta atgctagagc gttctcgcat
ctagctataa aactaataga 180gcaggaaatt gaccccgact caaccatcct
ggatatcggc agtgcgccag caaggaggat 240gatgtcggac aggaagtacc
actgcgtctg cccgatgcgc agtgcggaag atcccgagag 300actcgccaat
tatgcgagaa agctagcatc tgccgcagga aaagtcctgg acagaaacat
360ctctggaaag atcggggact tacaagcagt aatggccgtg ccagacacgg
agacgccaac 420attctgctta cacacagacg tctcatgtag acagagagca
gacgtcgcta tataccaaga 480cgtctatgct gtacacgcac ccacgtcgct
ataccaccag gcgattaaag gggtccgagt 540ggcgtactgg gttgggttcg
acacaacccc gttcatgtac aatgccatgg cgggtgccta 600cccctcatac
tcgacaaact gggcagatga gcaggtactg aaggctaaga acataggatt
660atgttcaaca gacctgacgg aaggtagacg aggcaagttg tctattatga
gagggaaaaa 720gctaaaaccg tgcgaccgtg tgctgttctc agtagggtca
acgctctacc cggaaagccg 780caagctactt aagagctggc acctgccatc
ggtgttccat ttaaagggca aactcagctt 840cacatgccgc tgtgatacag
tggtttcgtg tgagggctac gtcgttaaga gaataacgat 900gagcccaggc
ctttatggaa aaaccacagg gtatgcggta acccaccacg cagacggatt
960cctgatgtgc aagactaccg acacggttga cggcgaaaga gtgtcattct
cggtgtgcac 1020atacgtgccg gcgaccattt gtgatcaaat gaccggcatc
cttgctacag aagtcacgcc 1080ggaggatgca cagaagctgt tggtggggct
gaaccagaga atagtggtta acggcagaac 1140gcaacggaat acgaacacca
tgaaaaatta tctgcttccc gtggtcgccc aagccttcag 1200taagtgggca
aaggagtgcc ggaaagacat ggaagatgaa aaactcctgg gggtcagaga
1260aagaacactg acctgctgct gtctatgggc attcaagaag cagaaaacac
acacggtcta 1320caagaggcct gatacccagt caattcagaa ggttcaggcc
gagtttgaca gctttgtggt 1380accgagtctg tggtcgtccg ggttgtcaat
ccctttgagg actagaatca aatggttgtt 1440aagcaaggtg ccaaaaaccg
acctgatccc atacagcgga gacgcccgag aagcccggga 1500cgcagaaaaa
gaagcagagg aagaacgaga agcagaactg actcgcgaag ccctaccacc
1560tctacaggca gcacaggaag atgttcaggt cgaaatcgac gtggaacagc
ttgaggacag 1620agcgggcgca ggaataatag agactccgag aggagctatc
aaagttactg cccaaccaac 1680agaccacgtc gtgggagagt acctggtact
ctccccgcag accgtactac gtagccagaa 1740gctcagtctg attcacgctt
tggcggagca agtgaagacg tgcacgcaca acggacgagc 1800agggaggtat
gcggtcgaag cgtacgacgg ccgagtccta gtgccctcag gctatgcaat
1860ctcgcctgaa gacttccaga gtctaagcga aagcgcaacg atggtgtata
acgaaagaga 1920gttcgtaaac agaaagctac accatattgc gatgcacgga
ccagccctga acaccgacga 1980agagtcgtat gagctggtga gggcagagag
gacagaacac gagtacgtct acgacgtgga 2040tcagagaaga tgctgtaaga
aggaagaagc cgcaggactg gtactggtgg gcgacttgac 2100taatccgccc
taccacgaat tcgcatatga agggctaaaa atccgccctg cctgcccata
2160caaaattgca gtcataggag tcttcggagt accgggatct ggcaagtcag
ctattatcaa 2220gaacctagtt accaggcagg acctggtgac tagcggaaag
aaagaaaact gccaagaaat 2280caccaccgac gtgatgagac agagaggtct
agagatatct gcacgtacgg ttgactcgct 2340gctcttgaat ggatgcaaca
gaccagtcga cgtgttgtac gtagacgagg cgtttgcgtg 2400ccactctgga
acgctacttg ctttgatcgc cttggtgaga ccaaggcaga aagttgtact
2460ttgtggtgac ccgaagcagt gcggcttctt caatatgatg cagatgaaag
tcaactataa 2520tcacaacatc tgcacccaag tgtaccacaa aagtatctcc
aggcggtgta cactgcctgt 2580gaccgccatt gtgtcatcgt tgcattacga
aggcaaaatg cgcactacga atgagtacaa 2640caagccgatt gtagtggaca
ctacaggctc aacaaaacct gaccctggag acctcgtgtt 2700aacgtgcttc
agagggtggg ttaaacaact gcaaattgac tatcgtggat acgaggtcat
2760gacagcagcc gcatcccaag ggttaaccag aaaaggagtt tacgcagtta
gacaaaaagt 2820taatgaaaac ccgctctatg catcaacgtc agagcacgtc
aacgtactcc taacgcgtac 2880ggaaggtaaa ctggtatgga agacactttc
cggcgacccg tggataaaga cgctgcagaa 2940cccaccgaaa ggaaacttca
aagcaactat taaggagtgg gaggtggagc atgcatcaat 3000aatggcgggc
atctgcagtc accaaatgac cttcgataca ttccaaaata aagccaacgt
3060ttgttgggct aagagcttgg tccctatcct cgaaacagcg gggataaaac
taaatgatag 3120gcagtggtct cagataattc aagccttcaa agaagacaaa
gcatactcac ctgaagtagc 3180cctgaatgaa atatgtacgc gcatgtatgg
ggtggatcta gacagcgggc tattttctaa 3240accgttggtg tctgtgtatt
acgcggataa ccactgggat aataggcctg gagggaaaat 3300gttcggattt
aaccccgagg cagcatccat tctagaaaga aagtatccat tcacaaaagg
3360gaagtggaac atcaacaagc agatctgcgt gactaccagg aggatagaag
actttaaccc 3420taccaccaac atcataccgg ccaacaggag actaccacac
tcattagtgg ccgaacaccg 3480cccagtaaaa ggggaaagaa tggaatggct
ggttaacaag ataaacggcc accacgtgct 3540cctggtcagt ggctataacc
ttgcactgcc tactaagaga gtcacttggg tagcgccgtt 3600aggtgtccgc
ggagcggact acacatacaa cctagagttg ggtctgccag caacgcttgg
3660taggtatgac ctagtggtca taaacatcca cacacctttt cgcatacacc
attaccaaca 3720gtgcgtcgac cacgcaatga aactgcaaat gctcgggggt
gactcattga gactgctcaa 3780accgggcggc tctctattga tcagagcata
tggttacgca gatagaacca gtgaacgagt 3840catctgcgta ttgggacgca
agtttagatc gtctagagcg ttgaaaccac catgtgtcac 3900cagcaacact
gagatgtttt tcctattcag caactttgac aatggcagaa ggaatttcac
3960aactcatgtc atgaacaatc aactgaatgc agccttcgta ggacaggtca
cccgagcagg 4020atgtgcaccg tcgtaccggg taaaacgcat ggacatcgcg
aagaacgatg aagagtgcgt 4080agtcaacgcc gctaaccctc gcgggttacc
gggtgacggt gtttgcaagg cagtatacaa 4140aaaatggccg gagtccttta
agaacagtgc aacaccagtg ggaaccgcaa aaacagttat 4200gtgcggtacg
tatccagtaa tccacgctgt tggaccaaac ttctctaatt attcggagtc
4260tgaaggggac cgggaattgg cagctgccta tcgagaagtc gcaaaggaag
taactaggct 4320gggagtaaat agtgtagcta tacctctcct ctccacaggt
gtatactcag gagggaaaga 4380caggctgacc cagtcactga accacctctt
tacagccatg gactcgacgg atgcagacgt 4440ggtcatctac tgccgcgaca
aagaatggga gaagaaaata tctgaggcca tacagatgcg 4500gacccaagta
gagctgctgg atgagcacat ctccatagac tgcgatattg ttcgcgtgca
4560ccctgacagc agcttggcag gcagaaaagg atacagcacc acggaaggcg
cactgtactc 4620atatctagaa gggacccgtt ttcatcagac ggctgtggat
atggcggaga tacatactat 4680gtggccaaag caaacagagg ccaatgagca
agtctgccta tatgccctgg gggaaagtat 4740tgaatcgatc aggcagaaat
gcccggtgga tgatgcagac gcatcatctc cccccaaaac 4800tgtcccgtgc
ctttgccgtt acgctatgac tccagaacgc gtcacccggc ttcgcatgaa
4860ccacgtcaca agcataattg tgtgttcttc gtttcccctc ccaaagtaca
aaatagaagg 4920agtgcaaaaa gtcaaatgct ctaaggtaat gctatttgac
cacaacgtgc catcgcgcgt 4980aagtccaagg gaatatagat cttcccagga
gtctgcacag gaggcgagta caatcacgtc 5040actgacgcat agtcaattcg
acctaagcgt tgatggcgag atactgcccg tcccgtcaga 5100cctggatgct
gacgccccag ccctagaacc agcactagac gacggggcga cacacacgct
5160gccatccaca accggaaacc ttgcggccgt gtctgattgg gtaatgagca
ccgtacctgt 5220cgcgccgccc agaagaaggc gagggagaaa cctgactgtg
acatgtgacg agagagaagg 5280gaatataaca cccatggcta gcgtccgatt
ctttagggca gagctgtgtc cggtcgtaca 5340agaaacagcg gagacgcgtg
acacagcaat gtctcttcag gcaccaccga gtaccgccac 5400ggaaccgaat
catccgccga tctccttcgg agcatcaagc gagacgttcc ccattacatt
5460tggggacttc aacgaaggag aaatcgaaag cttgtcttct gagctactaa
ctttcggaga 5520cttcttacca ggagaagtgg atgacttgac agacagcgac
tggtccacgt gctcagacac 5580ggacgacgag ttatgactag acagggcagg
tgggtatata ttctcgtcgg acaccggtcc 5640aggtcattta caacagaagt
cagtacgcca gtcagtgctg ccggtgaaca ccctggagga 5700agtccacgag
gagaagtgtt acccacctaa gctggatgaa gcaaaggagc aactattact
5760taagaaactc caggagagtg catccatggc caacagaagc aggtatcagt
cgcgcaaagt 5820agaaaacatg aaagcagcaa tcatccagag actaaagaga
ggctgtagac tatacttaat 5880gtcagagacc ccaaaagtcc ctacttaccg
gactacatat ccggcgcctg tgtactcgcc 5940tccgatcaac gtccgattgt
ccaatcccga gtccgcagtg gcagcatgca atgagttctt 6000agctagaaac
tatccaactg tctcatcata ccaaattacc gacgagtatg atgcatatct
6060agacatggtg gacgggtcgg agagttgcct ggaccgagcg acattcaatc
cgtcaaaact 6120caggagctac ccgaaacagc acgcttacca cgcgccctcc
atcagaagcg ctgtaccgtc 6180cccattccag aacacactac agaatgtact
ggcagcagcc acgaaaagaa actgcaacgt 6240cacacagatg agggaattac
ccactttgga ctcagcagta ttcaacgtgg agtgtttcaa 6300aaaattcgca
tgcaaccaag aatactggga agaatttgct gccagcccta ttaggataac
6360aactgagaat ttagcaacct atgttactaa actaaaaggg ccaaaagcag
cagcgctatt 6420cgcaaaaacc cataatctac tgccactaca ggaagtacca
atggataggt tcacagtaga 6480tatgaaaagg gacgtgaagg tgactcctgg
tacaaagcat acagaggaaa gacctaaggt 6540gcaggttata caggcggctg
aacccttggc gacagcatac ctatgtggga ttcacagaga 6600gctggttagg
aggctgaacg ccgtcctcct acccaatgta catacactat ttgacatgtc
6660tgccgaggat ttcgatgcca tcatagccgc acactttaag ccaggagaca
ctgttttgga 6720aacggacata gcctcctttg ataagagcca
agatgattca cttgcgctta ctgctttgat 6780gctgttagag gatttagggg
tggatcactc cctgctggac ttgatagagg ctgctttcgg 6840agagatttcc
agctgtcacc taccgacagg tacgcgcttc aagttcggcg ccatgatgaa
6900atcaggtatg ttcctaactc tgttcgtcaa cacattgtta aacatcacca
tcgccagccg 6960agtgctggaa gatcgtctga caaaatccgc gtgcgcggcc
ttcatcggcg acgacaacat 7020aatacatgga gtcgtctccg atgaattgat
ggcagccaga tgtgccactt ggatgaacat 7080ggaagtgaag atcatagatg
cagttgtatc cttgaaagcc ccttactttt gtggagggtt 7140tatactgcac
gatactgtga caggaacagc ttgcagagtg gcagacccgc taaaaaggct
7200ttttaaactg ggcaaaccgc tagcggcagg tgacgaacaa gatgaagata
gaagacgagc 7260gctggctgac gaagtgatca gatggcaacg aacagggcta
attgatgagc tggagaaagc 7320ggtatactct aggtacgaag tgcagggtat
atcagttgtg gtaatgtcca tggccacctt 7380tgcaagctcc agatccaact
tcgagaagct cagaggaccc gtcataactt tgtacggcgg 7440tcctaaatag
gtacgcacta cagctaccta ttttgcagaa gccgacagca agtatctaaa
7500cactaatcag ctacaatgga gttcatccca acccaaactt tttacaatag
gaggtaccag 7560cctcgaccct ggactccgcg ccctactatc caagtcatca
ggcccagacc gcgccctcag 7620aggcaagctg ggcaacttgc ccagctgatc
tcagcagtta ataaactgac aatgcgcgcg 7680gtaccccaac agaagccacg
caggaatcgg aagaataaga agcaaaagca aaaacaacag 7740gcgccacaaa
acaacacaaa tcaaaagaag cagccaccta aaaagaaacc ggctcaaaag
7800aaaaagaagc cgggccgcag agagaggatg tgcatgaaaa tcgaaaatga
ttgtattttc 7860gaagtcaagc acgaaggtaa ggtaacaggt tacgcgtgcc
tggtggggga caaagtaatg 7920aaaccagcac acgtaaaggg gaccatcgat
aacgcggacc tggccaaact ggcctttaag 7980cggtcatcta agtatgacct
tgaatgcgcg cagatacccg tgcacatgaa gtccgacgct 8040tcgaagttca
cccatgagaa accggagggg tactacaact ggcaccacgg agcagtacag
8100tactcaggag gccggttcac catccctaca ggtgctggca aaccagggga
cagcggcaga 8160ccgatcttcg acaacaaggg acgcgtggtg gccatagtct
taggaggagc taatgaagga 8220gcccgtacag ccctctcggt ggtgacctgg
aataaagaca ttgtcactaa aatcaccccc 8280gagggggccg aagagtggag
tcttgccatc ccagttatgt gcctgttggc aaacaccacg 8340ttcccctgct
cccagccccc ttgcacgccc tgctgctacg aaaaggaacc ggaggaaacc
8400ctacgcatgc ttgaggacaa cgtcatgaga cctgggtact atcagctgct
acaagcatcc 8460ttaacatgtt ctccccaccg ccagcgacgc agcaccaagg
acaacttcaa tgtctataaa 8520gccacaagac catacttagc tcactgtccc
gactgtggag aagggcactc gtgccatagt 8580cccgtagcac tagaacgcat
cagaaatgaa gcgacagacg ggacgctgaa aatccaggtc 8640tccttgcaaa
tcggaataaa gacggatgac agccacgatt ggaccaagct gcgttatatg
8700gacaaccaca tgccagcaga cgcagagagg gcggggctat ttgtaagaac
atcagcaccg 8760tgtacgatta ctggaacaat gggacacttc atcctggccc
gatgtccaaa aggggaaact 8820ctgacggtgg gattcactga cagtaggaag
attagtcact catgtacgca cccatttcac 8880cacgaccctc ctgtgatagg
tcgggaaaaa ttccattccc gaccgcagca cggtaaagag 8940ctaccttgca
gcacgtacgt gcagagcacc gccgcaacta ccgaggagat agaggtacac
9000atgcccccag acacccctga tcgcacatta atgtcacaac agtccggcaa
cgtaaagatc 9060acagtcaatg gccagacggt gcggtacaag tgtaattgcg
gtggctcaaa tgaaggacta 9120acaactacag acaaagtgat taataactgc
aaggttgatc aatgtcatgc cgcggtcacc 9180aatcacaaaa agtggcagta
taactcccct ctggtcccgc gtaatgctga acttggggac 9240cgaaaaggaa
aaattcacat cccgtttccg ctggcaaatg taacatgcag ggtgcctaaa
9300gcaaggaacc ccaccgtgac gtacgggaaa aaccaagtca tcatgctact
gtatcctgac 9360cacccaacac tcctgtccta ccggaatatg ggagaagaac
caaactatca agaagagtgg 9420gtgatgcata agaaggaagt cgtgctaacc
gtgccgactg aagggctcga ggtcacgtgg 9480ggcaacaacg agccgtataa
gtattggccg cagttatcta caaacggtac agcccatggc 9540cacccgcatg
agataattct gtattattat gagctgtacc ccactatgac tgtagtagtt
9600gtgtcagtgg ccacgttcat actcctgtcg atggtgggta tggcagcggg
gatgtgcatg 9660tgtgcacgac gcagatgcat cacaccgtat gaactgacac
caggagctac cgtccctttc 9720ctgcttagcc taatatgctg catcagaaca
gctaaagcgg ccacatacca agaggctgcg 9780atatacctgt ggaacgagca
gcaacctttg ttttggctac aagcccttat tccgctggca 9840gccctgattg
ttctatgcaa ctgtctgaga ctcttaccat gctgctgtaa aacgttggct
9900tttttagccg taatgagcgt cggtgcccac actgtgagcg cgtacgaaca
cgtaacagtg 9960atcccgaaca cggtgggagt accgtataag actctagtca
atagacctgg ctacagcccc 10020atggtattgg agatggaact actgtcagtc
actttggagc caacactatc gcttgattac 10080atcacgtgcg agtacaaaac
cgtcatcccg tctccgtacg tgaagtgctg cggtacagca 10140gagtgcaagg
acaaaaacct acctgactac agctgtaagg tcttcaccgg cgtctaccca
10200tttatgtggg gcggcgccta ctgcttctgc gacgctgaaa acacgcagtt
gagcgaagca 10260cacgtggaga agtccgaatc atgcaaaaca gaatttgcat
cagcatacag ggctcatacc 10320gcatctgcat cagctaagct ccgcgtcctt
taccaaggaa ataacatcac tgtaactgcc 10380tatgcaaacg gcgaccatgc
cgtcacagtt aaggacgcca aattcattgt ggggccaatg 10440tcttcagcct
ggacaccttt cgacaacaaa attgtggtgt acaaaggtga cgtctataac
10500atggactacc cgccctttgg cgcaggaaga ccaggacaat ttggcgatat
ccaaagtcgc 10560acacctgaga gtaaagacgt ctatgctaat acacaactgg
tactgcagag accggctgtg 10620ggtacggtac acgtgccata ctctcaggca
ccatctggct ttaagtattg gctaaaagaa 10680cgcggggcgt cgctgcagca
cacagcacca tttggctgcc aaatagcaac aaacccggta 10740agagcggtga
actgcgccgt agggaacatg cccatctcca tcgacatacc ggaagcggcc
10800ttcactaggg tcgtcgacgc gccctcttta acggacatgt cgtgcgaggt
accagcctgc 10860acccattcct cagactttgg gggcgtcgcc attattaaat
atgcagccag caagaaaggc 10920aagtgtgcgg tgcattcgat gactaacgcc
gtcactattc gggaagctga gatagaagtt 10980gaagggaatt ctcagctgca
aatctctttc tcgacggcct tagccagcgc cgaattccgc 11040gtacaagtct
gttctacaca agtacactgt gcagccgagt gccacccccc gaaggaccac
11100atagtcaact acccggcgtc acataccacc ctcggggtcc aggacatctc
cgctacggcg 11160atgtcatggg tgcagaagat cacgggaggt gtgggactgg
ttgttgctgt tgccgcactg 11220attctaatcg tggtgctatg cgtgtcgttc
agcaggcact aacttgacaa ttaagtatga 11280aggtatatgt gtcccctaag
agacacactg tacatagcaa ataatctata gatcaaaggg 11340ctacgcaacc
cctgaatagt aacaaaatac aaaatcacta aaaattataa aaacagaaaa
11400atacataaat aggtatacgt gtcccctaag agacacattg tatgtaggtg
ataagtatag 11460atcaaagggc cgaataaccc ctgaatagta acaaaatatg
aaaatcaata aaaatcataa 11520aatagaaaaa ccataaacag aagtagttca
aagggctata aaacccctga atagtaacaa 11580aacataaaat taataaaaat c
11601411598DNAChikungunya virus 4caaagcaaga gattaataac ccatcatgga
tcctgtgtac gtggacatag acgctgacag 60cgcctttttg aaggccctgc aacgtgcgta
ccccatgttt gaggtggaac caaggcaggt 120cacaccgaat gaccatgcta
atgctagagc gttctcgcat ctagctataa aactaataga 180gcaggaaatt
gaccccgact caaccatcct ggatatcggc agtgcgccag caaggaggat
240gatgtcggac aggaagtacc actgcgtctg cccgatgcgc agtgcggaag
atcccgagag 300actcgccaat tatgcgagaa agctagcatc tgccgcagga
aaagtcctgg acagaaacat 360ctctggaaag atcggggact tacaagcagt
aatggccgtg ccagacacgg agacgccaac 420attctgctta cacacagacg
tctcatgtag acagagagca gacgtcgcta tataccaaga 480cgtctatgct
gtacacgcac ccacgtcgct ataccaccag gcgattaaag gggtccgagt
540ggcgtactgg gttgggttcg acacaacccc gttcatgtac aatgccatgg
cgggtgccta 600cccctcatac tcgacaaact gggcagatga gcaggtactg
aaggctaaga acataggatt 660atgttcaaca gacctgacgg aaggtagacg
aggcaagttg tctattatga gagggaaaaa 720gctaaaaccg tgcgaccgtg
tgctgttctc agtagggtca acgctctacc cggaaagccg 780caagctactt
aagagctggc acctgccatc ggtgttccat ttaaagggca aactcagctt
840cacatgccgc tgtgatacag tggtttcgtg tgagggctac gtcgttaaga
gaataacgat 900gagcccaggc ctttatggaa aaaccatagg gtatgcggta
acccaccacg cagacggatt 960cctgatgtgc aagactaccg acacggttga
cggcgaaaga gtgtcattct cggtgtgcac 1020atacgtgccg gcgaccattt
gtgatcaaat gaccggcatc cttgctacag aagtcacgcc 1080ggaggatgca
cagaagctgt tggtggggct gaaccagaga atagtggtta acggcagaac
1140gcaacggaat acgaacacca tgaaaaatta tctgcttccc gtggtcgccc
aagccttcag 1200taagtgggca aaggagtgcc ggaaagacat ggaagatgaa
aaactcctgg gggtcagaga 1260aagaacactg acctgctgct gtctatgggc
attcaagaag cagaaaacac acacggtcta 1320caagaggcct gatacccagt
caattcagaa ggttcaggcc gagtttgaca gctttgtggt 1380accgagtctg
tggtcgtccg ggttgtcaat ccctttgagg actagaatca aatggttgtt
1440aagcaaggtg ccaaaaaccg acctgatccc atacagcgga gacgcccgag
aagcccggga 1500cgcagaaaaa gaagcagagg aagaacgaga agcagaactg
actcgcgaag ccctaccacc 1560tctacaggca gcacaggaag atgttcaggt
cgaaatcgac gtggaacagc ttgaggacag 1620agcgggcgca ggaataatag
agactccgag aggagctatc aaagttactg cccaaccaac 1680agaccacgtc
gtgggagagt acctggtact ctccccgcag accgtactac gtagccagaa
1740gctcagtctg attcacgctt tggcggagca agtgaagacg tgcacgcaca
acggacgagc 1800agggaggtat gcggtcgaag cgtacgacgg ccgagtccta
gtgccctcag gctatgcaat 1860ctcgcctgaa gacttccaga gtctaagcga
aagcgcaacg atggtgtata acgaaagaga 1920gttcgtaaac agaaagctac
accatattgc gatgcacgga ccagccctga acaccgacga 1980agagtcgtat
gagctggtga gggcagagag gacagaacac gagtacgtct acgacgtgga
2040tcagagaaga tgctgtaaga aggaagaagc cgcaggactg gtactggtgg
gcgacttgac 2100taatccgccc taccacgaat tcgcatatga agggctaaaa
atccgccctg cctgcccata 2160caaaattgca gtcataggag tcttcggagt
accgggatct ggcaagtcag ctattatcaa 2220gaacctagtt accaggcagg
acctggtgac tagcggaaag aaagaaaact gccaagaaat 2280caccaccgac
gtgatgagac agagaggtct agagatatct gcacgtacgg ttgactcgct
2340gctcttgaat ggatgcaaca gaccagtcga cgtgttgtac gtagacgagg
cgtttgcgtg 2400ccactctgga acgctacttg ctttgatcgc cttggtgaga
ccaaggcaga aagttgtact 2460ttgtggtgac ccgaagcagt gcggcttctt
caatatgatg cagatgaaag tcaactataa 2520tcacaacatc tgcacccaag
tgtaccacaa aagtatctcc aggcggtgta cactgcctgt 2580gaccgccatt
gtgtcatcgt tgcattacga aggcaaaatg cgcactacga atgagtacaa
2640caagccgatt gtagtggaca ctacaggctc aacaaaacct gaccctggag
acctcgtgtt 2700aacgtgcttc agagggtggg ttaaacaact gcaaattgac
tatcgtggat acgaggtcat 2760gacagcagcc gcatcccaag ggttaaccag
aaaaggagtt tacgcagtta gacaaaaagt 2820taatgaaaac ccgctctatg
catcaacgtc agagcacgtc aacgtactcc taacgcgtac 2880ggaaggtaaa
ctggtatgga agacactttc cggcgacccg tggataaaga cgctgcagaa
2940cccaccgaaa ggaaacttca aagcaactat taaggagtgg gaggtggagc
atgcatcaat 3000aatggcgggc atctgcagtc accaaatgac cttcgataca
ttccaaaata aagccaacgt 3060ttgttgggct aagagcttgg tccctatcct
cgaaacagcg gggataaaac taaatgatag 3120gcagtggtct cagataattc
aagccttcaa agaagacaaa gcatactcac ctgaagtagc 3180cctgaatgaa
atatgtacgc gcatgtatgg ggtggatcta gacagcgggc tattttctaa
3240accgttggtg tctgtgtatt acgcggataa ccactgggat aataggcctg
gagggaaaat 3300gttcggattt aaccccgagg cagcatccat tctagaaaga
aagtatccat tcacaaaagg 3360gaagtggaac atcaacaagc agatctgcgt
gactaccagg aggatagaag actttaaccc 3420taccaccaac atcataccgg
ccaacaggag actaccacac tcattagtgg ccgaacaccg 3480cccagtaaaa
ggggaaagaa tggaatggct ggttaacaag ataaacggcc accacgtgct
3540cctggtcagt ggcaataacc ttgcactgcc tactaagaga gtcacttggg
tagcgccgtt 3600aggtgtccgc ggagcggact acacatacaa cctagagttg
ggtctgccag caacgcttgg 3660taggtatgac ctagtggtca taaacatcca
cacacctttt cgcatacacc attaccaaca 3720gtgcgtcgac cacgcaatga
aactgcaaat gctcgggggt gactcattga gactgctcaa 3780accgggcggc
tctctattga tcagagcata tggttacgca gatagaacca gtgaacgagt
3840catctgcgta ttgggacgca agtttagatc gtctagagcg ttgaaaccac
catgtgtcac 3900cagcaacact gagatgtttt tcctattcag caactttgac
aatggcagaa ggaatttcac 3960aactcatgtc atgaacaatc aactgaatgc
agccttcgta ggacaggtca cccgagcagg 4020atgtgcaccg tcgtaccggg
taaaacgcat ggacatcgcg aagaacgatg aagagtgcgt 4080agtcaacgcc
gctaaccctc gcgggttacc gggtgacggt gtttgcaagg cagtatacaa
4140aaaatggccg gagtccttta agaacagtgc aacaccagtg ggaaccgcaa
aaacagttat 4200gtgcggtacg tatccagtaa tccacgctgt tggaccaaac
ttctctaatt attcggagtc 4260tgaaggggac cgggaattgg cagctgccta
tcgagaagtc gcaaaggaag taactaggct 4320gggagtaaat agtgtagcta
tacctctcct ctccacaggt gtatactcag gagggaaaga 4380caggctgacc
cagtcactga accacctctt tacagccatg gactcgacgg atgcagacgt
4440ggtcatctac tgccgcgaca aagaatggga gaagaaaata tctgaggcca
tacagatgcg 4500gacccaagta gagctgctgg atgagcacat ctccatagac
tgcgatattg ttcgcgtgca 4560ccctgacagc agcttggcag gcagaaaagg
atacagcacc acggaaggcg cactgtactc 4620atatctagaa gggacccgtt
ttcatcagac ggcagtggat atggcggaga tacatactat 4680gtggccaaag
caaacagagg ccaatgagca agtctgccta tatgccctgg gggaaagtat
4740tgaatcgatc aggcagaaat gcccggtgga tgatgcagac gcatcatctc
cccccaaaac 4800tgtcccgtgc ctttgccgtt acgctatgac tccagaacgc
gtcacccggc ttcgcatgaa 4860ccacgtcaca agcataattg tgtgttcttc
gtttcccctc ccaaagtaca aaatagaagg 4920agtgcaaaaa gtcaaatgct
ctaaggtaat gctatttgac cacaacgtgc catcgcgcgt 4980aagtccaagg
gaatatagat cttcccagga gtctgcacag gaggcgagta caatcacgtc
5040actgacgcat agtcaattcg acctaagcgt tgatggcgag atactgcccg
tcccgtcaga 5100cctggatgct gacgccccag ccctagaacc agcactagac
gacggggcga cacacacgct 5160gccatccaca accggaaacc ttgcggccgt
gtctgattgg gtaatgagca ccgtacctgt 5220cgcgccgccc agaagaaggc
gagggagaaa cctgactgtg acatgtgacg agagagaagg 5280gaatataaca
cccatggcta gcgtccgatt ctttagggca gagctgtgtc cggtcgtaca
5340agaaacagcg gagacgcgtg acacagcaat gtctcttcag gcaccaccga
gtaccgccac 5400accgaatcat ccgccgatct ccttcggagc atcaagcgag
acgttcccca ttacatttgg 5460ggacttcaac gaaggagaaa tcgaaagctt
gtcttctgag ctactaactt tcggagactt 5520cttaccagga gaagtggatg
acttgacaga cagcgactgg tccacgtgct cagacacgga 5580cgacgagtta
tgactagaca gggcaggtgg gtatatattc tcgtcggaca ccggtccagg
5640tcatttacaa cagaagtcag tacgccagtc agtgctgccg gtgaacaccc
tggaggaagt 5700ccacgaggag aagtgttacc cacctaagct ggatgaagca
aaggagcaac tattacttaa 5760gaaactccag gagagtgcat ccatggccaa
cagaagcagg tatcagtcgc gcaaagtaga 5820aaacatgaaa gcagcaatca
tccagagact aaagagaggc tgtagactat acttaatgtc 5880agagacccca
aaagtcccta cttaccggac tacatatccg gcgcctgtgt actcgcctcc
5940gatcaacgtc cgattgtcca atcccgagtc cgcagtggca gcatgcaatg
agttcttagc 6000tagaaactat ccaactgtct catcatacca aattaccgac
gagtatgatg catatctaga 6060catggtggac gggtcggaga gttgcctgga
ccgagcgaca ttcaatccgt caaaactcag 6120gagctacccg aaacagcacg
cttaccacgc gccctccatc agaagcgctg taccgtcccc 6180attccagaac
acactacaga atgtactggc agcagccacg aaaagaaact gcaacgtcac
6240acagatgagg gaattaccca ctttggactc agcagtattc aacgtggagt
gtttcaaaaa 6300attcgcatgc aaccaagaat actgggaaga atttgctgcc
agccctatta ggataacaac 6360tgagaattta gcaacctatg ttactaaact
aaaagggcca aaagcagcag cgctattcgc 6420aaaaacccat aatctactgc
cactacagga agtaccaatg gataggttca cagtagatat 6480gaaaagggac
gtaaaggtga ctcctggtac aaagcataca gaggaaagac ctaaggtgca
6540ggttatacag gcggctgaac ccttggcgac agcataccta tgtgggattc
acagagagct 6600ggttaggagg ctgaacgccg tcctcctacc caatgtacat
acactatttg acatgtctgc 6660cgaggatttc gatgccatca tagccgcaca
ctttaagcca ggagacactg ttttggaaac 6720ggacatagcc tcctttgata
agagccaaga tgattcactt gcgcttactg ctttgatgct 6780gttagaggat
ttaggggtgg atcactccct gctggacttg atagaggctg ctttcggaga
6840gatttccagc tgtcacctac cgacaggtac gcgcttcaag ttcggcgcca
tgatgaaatc 6900aggtatgttc ctaactctgt tcgtcaacac attgttaaac
atcaccatcg ccagccgagt 6960gctggaagat cgtctgacaa aatccgcgtg
cgcggccttc atcggcgacg acaacataat 7020acatggagtc gtctccgatg
aattgatggc agccagatgt gccacttgga tgaacatgga 7080agtgaagatc
atagatgcag ttgtatcctt gaaagcccct tacttttgtg gagggtttat
7140actgcacgat actgtgacag gaacagcttg cagagtggca gacccgctaa
aaaggctttt 7200taaactgggc aaaccgctag cggcaggtga cgaacaagat
gaagatagaa gacgagcgct 7260ggctgacgaa gtgatcagat ggcaacgaac
agggctaatt gatgagctgg agaaagcggt 7320atactctagg tacgaagtgc
agggtatatc agttgtggta atgtccatgg ccacctttgc 7380aagctccaga
tccaacttcg agaagctcag aggacccgtc ataactttgt acggcggtcc
7440taaataggta cgcactacag ctacctattt tgcagaagcc gacagcaagt
atctaaacac 7500taatcagcta caatggagtt catcccaacc caaacttttt
acaataggag gtaccagcct 7560cgaccctgga ctccgcgccc tactatccaa
gtcatcaggc ccagaccgcg ccctcagagg 7620caagctgggc aacttgccca
gctgatctca gcagttaata aactgacaat gcgcgcggta 7680ccccaacaga
agccacgcag gaatcggaag aataagaagc aaaagcaaaa acaacaggcg
7740ccacaaaaca acacaaatca aaagaagcag ccacctaaaa agaaaccggc
tcaaaagaaa 7800aagaagccgg gccgcagaga gaggatgtgc atgaaaatcg
aaaatgattg tattttcgaa 7860gtcaagcacg aaggtaaggt aacaggttac
gcgtgcctgg tgggggacaa agtaatgaaa 7920ccagcacacg taaaggggac
catcgataac gcggacctgg ccaaactggc ctttaagcgg 7980tcatctaagt
atgaccttga atgcgcgcag atacccgtgc acatgaagtc cgacgcttcg
8040aagttcaccc atgagaaacc ggaggggtac tacaactggc accacggagc
agtacagtac 8100tcaggaggcc ggttcaccat ccctacaggt gctggcaaac
caggggacag cggcagaccg 8160atcttcgaca acaagggacg cgtggtggcc
atagtcttag gaggagctaa tgaaggagcc 8220cgtacagccc tctcggtggt
gacctggaat aaagacattg tcactaaaat cacccccgag 8280ggggccgaag
agtggagtct tgccatccca gttatgtgcc tgttggcaaa caccacgttc
8340ccctgctccc agcccccttg cacgccctgc tgctacgaaa aggaaccgga
ggaaacccta 8400cgcatgcttg aggacaacgt catgagacct gggtactatc
agctgctaca agcatcctta 8460acatgttctc cccaccgcca gcgacgcagc
accaaggaca acttcaatgt ctataaagcc 8520acaagaccat acttagctca
ctgtcccgac tgtggagaag ggcactcgtg ccatagtccc 8580gtagcactag
aacgcatcag aaatgaagcg acagacggga cgctgaaaat ccaggtctcc
8640ttgcaaatcg gaataaagac ggatgacagc cacgattgga ccaagctgcg
ttatatggac 8700aaccacatgc cagcagacgc agagagggcg gggctatttg
taagaacatc agcaccgtgt 8760acgattactg gaacaatggg acacttcatc
ctggcccgat gtccaaaagg ggaaactctg 8820acggtgggat tcactgacag
taggaagatt agtcactcat gtacgcaccc atttcaccac 8880gaccctcctg
tgataggtcg ggaaaaattc cattcccgac cgcagcacgg taaagagcta
8940ccttgcagca cgtacgtgca gagcaccgcc gcaactaccg aggagataga
ggtacacatg 9000cccccagaca cccctgatcg cacattaatg tcacaacagt
ccggcaacgt aaagatcaca 9060gtcaatggcc agacggtgcg gtacaagtgt
aattgcggtg gctcaaatga aggactaaca 9120actacagaca aagtgattaa
taactgcaag gttgatcaat gtcatgccgc ggtcaccaat 9180cacaaaaagt
ggcagtataa ctcccctctg gtcccgcgta atgctgaact tggggaccga
9240aaaggaaaaa ttcacatccc gtttccgctg gcaaatgtaa catgcagggt
gcctaaagca 9300aggaacccca ccgtgacgta cgggaaaaac caagtcatca
tgctactgta tcctgaccac 9360ccaacactcc tgtcctaccg gaatatggga
gaagaaccaa actatcaaga agagtgggtg 9420atgcataaga aggaagtcgt
gctaaccgtg ccgactgaag ggctcgaggt cacgtggggc 9480aacaacgagc
cgtataagta ttggccgcag ttatctacaa acggtacagc ccatggccac
9540ccgcatgaga taattctgta ttattatgag ctgtacccca ctatgactgt
agtagttgtg 9600tcagtggcca cgttcatact cctgtcgatg gtgggtatgg
cagcggggat gtgcatgtgt 9660gcacgacgca gatgcatcac accgtatgaa
ctgacaccag gagctaccgt ccctttcctg 9720cttagcctaa tatgctgcat
cagaacagct aaagcggcca cataccaaga ggctgcgata 9780tacctgtgga
acgagcagca acctttgttt tggctacaag cccttattcc gctggcagcc
9840ctgattgttc tatgcaactg tctgagactc ttaccatgct gctgtaaaac
gttggctttt 9900ttagccgtaa tgagcgtcgg tgcccacact gtgagcgcgt
acgaacacgt aacagtgatc 9960ccgaacacgg tgggagtacc gtataagact
ctagtcaata gacctggcta cagccccatg 10020gtattggaga tggaactact
gtcagtcact ttggagccaa cactatcgct tgattacatc 10080acgtgcgagt
acaaaaccgt catcccgtct ccgtacgtga agtgctgcgg tacagcagag
10140tgcaaggaca aaaacctacc tgactacagc tgtaaggtct tcaccggcgt
ctacccattt 10200atgtggggcg gcgcctactg cttctgcgac gctgaaaaca
cgcagttgag cgaagcacac 10260gtggagaagt ccgaatcatg caaaacagaa
tttgcatcag catacagggc tcataccgca 10320tctgcatcag ctaagctccg
cgtcctttac caaggaaata acatcactgt aactgcctat 10380gcaaacggcg
accatgccgt cacagttaag gacgccaaat tcattgtggg gccaatgtct
10440tcagcctgga cacctttcga caacaaaatt gtggtgtaca aaggtgacgt
ctataacatg 10500gactacccgc cctttggcgc aggaagacca ggacaatttg
gcgatatcca aagtcgcaca 10560cctgagagta aagacgtcta tgctaataca
caactggtac tgcagagacc ggctgtgggt 10620acggtacacg tgccatactc
tcaggcacca tctggcttta agtattggct aaaagaacgc 10680ggggcgtcgc
tgcagcacac agcaccattt ggctgccaaa tagcaacaaa cccggtaaga
10740gcggtgaact gcgccgtagg gaacatgccc atctccatcg acataccgga
agcggccttc 10800actagggtcg tcgacgcgcc ctctttaacg gacatgtcgt
gcgaggtacc agcctgcacc 10860cattcctcag actttggggg cgtcgccatt
attaaatatg cagccagcaa gaaaggcaag 10920tgtgcggtgc attcgatgac
taacgccgtc actattcggg aagctgagat agaagttgaa 10980gggaattctc
agctgcaaat ctctttctcg acggccttag ccagcgccga attccgcgta
11040caagtctgtt ctacacaagt acactgtgca gccgagtgcc accccccgaa
ggaccacata 11100gtcaactacc cggcgtcaca taccaccctc ggggtccagg
acatctccgc tacggcgatg 11160tcatgggtgc agaagatcac gggaggtgtg
ggactggttg ttgctgttgc cgcactgatt 11220ctaatcgtgg tgctatgcgt
gtcgttcagc aggcactaac ttgacaatta agtatgaagg 11280tatatgtgtc
ccctaagaga cacactgtac atagcaaata atctatagat caaagggcta
11340cgcaacccct gaatagtaac aaaatacaaa atcactaaaa attataaaaa
cagaaaaata 11400cataaatagg tatacgtgtc ccctaagaga cacattgtat
gtaggtgata agtatagatc 11460aaagggccga ataacccctg aatagtaaca
aaatatgaaa atcaataaaa atcataaaat 11520agaaaaacca taaacagaag
tagttcaaag ggctataaaa cccctgaata gtaacaaaac 11580ataaaattaa
taaaaatc 11598511601DNAChikungunya virus 5caaagcaaga gattaataac
ccatcatgga tcctgtgtac gtggacatag acgctgacag 60cgcctttttg aaggccctgc
aacgtgcgta ccccatgttt gaggtggaac caaggcaggt 120cacaccgaat
gaccatgcta atgctagagc gttctcgcat ctagctataa aactaataga
180gcaggaaatt gaccccgact caaccatcct ggatatcggc agtgcgccag
caaggaggat 240gatgtcggac aggaagtacc actgcgtctg cccgatgcgc
agtgcggaag atcccgagag 300actcgccaat tatgcgagaa agctagcatc
tgccgcagga aaagtcctgg acagaaacat 360ctctggaaag atcggggact
tacaagcagt aatggccgtg ccagacacgg agacgccaac 420attctgctta
cacacagacg tctcatgtag acagagagca gacgtcgcta tataccaaga
480cgtctatgct gtacacgcac ccacgtcgct ataccaccag gcgattaaag
gggtccgagt 540ggcgtactgg gttgggttcg acacaacccc gttcatgtac
aatgccatgg cgggtgccta 600cccctcatac tcgacaaact gggcagatga
gcaggtactg aaggctaaga acataggatt 660atgttcaaca gacctgacgg
aaggtagacg aggcaagttg tctattatga gagggaaaaa 720gctaaaaccg
tgcgaccgtg tgctgttctc agtagggtca acgctctacc cggaaagccg
780caagctactt aagagctggc acctgccatc ggtgttccat ttaaagggca
aactcagctt 840cacatgccgc tgtgatacag tggtttcgtg tgagggctac
gtcgttaaga gaataacgat 900gagcccaggc ctttatggaa aaaccacagg
gtatgcggta acccaccacg cagacggatt 960cctgatgtgc aagactaccg
acacggttga cggcgaaaga gtgtcattct cggtgtgcac 1020atacgtgccg
gcgaccattt gtgatcaaat gaccggcatc cttgctacag aagtcacgcc
1080ggaggatgca cagaagctgt tggtggggct gaaccagaga atagtggtta
acggcagaac 1140gcaacggaat acgaacacca tgaaaaatta tctgcttccc
gtggtcgccc aagccttcag 1200taagtgggca aaggagtgcc ggaaagacat
ggaagatgaa aaactcctgg gggtcagaga 1260aagaacactg acctgctgct
gtctatgggc attcaagaag cagaaaacac acacggtcta 1320caagagacct
gatacccagt caattcagaa ggttcaggcc gagtttgaca gctttgtggt
1380accgagtctg tggtcgtccg ggttgtcaat ccctttgagg actagaatca
aatggttgtt 1440aagcaaggtg ccaaaaaccg acctgatccc atacagcgga
gacgcccgag aagcccggga 1500cgcagaaaaa gaagcagagg aagaacgaga
agcagaactg actcgcgaag ccctaccacc 1560tctacaggca gcacaggaag
atgttcaggt cgaaatcgac gtggaacagc ttgaggacag 1620agcgggcgca
ggaataatag agactccgag aggagctatc aaagttactg cccaaccaac
1680agaccacgtc gtgggagagt acctggtact ctccccgcag accgtactac
gtagccagaa 1740gctcagtctg attcacgctt tggcggagca agtgaagacg
tgcacgcaca acggacgagc 1800agggaggtat gcggtcgaag cgtacgacgg
ccgagtccta gtgccctcag gctatgcaat 1860ctcgcctgaa gacttccaga
gtctaagcga aagcgcaacg atggtgtata acgaaagaga 1920gttcgtaaac
agaaagctac accatattgc gatgcacgga ccagccctga acaccgacga
1980agagtcgtat gagctggtga gggcagagag gacagaacac gagtacgtct
acgacgtgga 2040tcagagaaga tgctgtaaga aggaagaagc cgcaggactg
gtactggtgg gcgacttgac 2100taatccgccc taccacgaat tcgcatatga
agggctaaaa atccgccctg cctgcccata 2160caaaattgca gtcataggag
tcttcggagt accgggatct ggcaagtcag ctattatcaa 2220gaacctagtt
accaggcagg acctggtgac tagcggaaag aaagaaaact gccaagaaat
2280caccaccgac gtgatgagac agagaggtct agagatatct gcacgtacgg
ttgactcgct 2340gctcttgaat ggatgcaaca gaccagtcga cgtgttgtac
gtagacgagg cgtttgcgtg 2400ccactctgga acgctacttg ctttgatcgc
cttggtgaga ccaaggcaga aagttgtact 2460ttgtggtgac ccgaagcagt
gcggcttctt caatatgatg cagatgaaag tcaactataa 2520tcacaacatc
tgcacccaag tgtaccacaa aagtatctcc aggcggtgta cactgcctgt
2580gaccgccatt gtgtcatcgt tgcattacga aggcaaaatg cgcactacga
atgagtacaa 2640caagccgatt gtagtggaca ctacaggctc aacaaaacct
gaccctggag acctcgtgtt 2700aacgtgcttc agagggtggg ttaaacaact
gcaaattgac tatcgtggat acgaggtcat 2760gacagcagcc gcatcccaag
ggttaaccag aaaaggagtt tacgcagtta gacaaaaagt 2820taatgaaaac
ccgctctatg catcaacgtc agagcacgtc aacgtactcc taacgcgtac
2880ggaaggtaaa ctggtatgga agacactttc cggcgacccg tggataaaga
cgctgcagaa 2940cccaccgaaa ggaaacttca aagcaactat taaggagtgg
gaggtggagc atgcatcaat 3000aatggcgggc atctgcagtc accaaatgac
cttcgataca ttccaaaata aagccaacgt 3060ttgttgggct aagagcttgg
tccctatcct cgaaacagcg gggataaaac taaatgatag 3120gcagtggtct
cagataattc aagccttcaa agaagacaaa gcatactcac ctgaagtagc
3180cctgaatgaa atatgtacgc gcatgtatgg ggtggatcta gacagcgggc
tattttctaa 3240accgttggtg tctgtgtatt acgcggataa ccactgggat
aataggcctg gagggaaaat 3300gttcggattt aaccccgagg cagcatccat
tctagaaaga aagtatccat tcacaaaagg 3360gaagtggaac atcaacaagc
agatctgcgt gactaccagg aggatagaag actttaaccc 3420taccaccaac
atcataccgg ccaacaggag actaccacac tcattagtgg ccgaacaccg
3480cccagtaaaa ggggaaagaa tggaatggct ggttaacaag ataaacggcc
accacgtgct 3540cctggtcagt ggctataacc ttgcactgcc tactaagaga
gtcacttggg tagcgccgtt 3600aggtgtccgc ggagcggact acacatacaa
cctagagttg ggtctgccag caacgcttgg 3660taggtatgac ctagtggtca
taaacatcca cacacctttt cgcatacacc attaccaaca 3720gtgcgtcgac
cacgcaatga aactgcaaat gctcgggggt gactcattga gactgctcaa
3780accgggcggc tctctattga tcagagcata tggttacgca gatagaacca
gtgaacgagt 3840catctgcgta ttgggacgca agtttagatc gtctagagcg
ttgaaaccac catgtgtcac 3900cagcaacact gagatgtttt tcctattcag
caactttgac aatggcagaa ggaatttcac 3960aactcatgtc atgaacaatc
aactgaatgc agccttcgta ggacaggtca cccgagcagg 4020atgtgcaccg
tcgtaccggg taaaacgcat ggacatcgcg aagaacgatg aagagtgcgt
4080agtcaacgcc gctaaccctc gcgggttacc gggtgacggt gtttgcaagg
cagtatacaa 4140aaaatggccg gagtccttta agaacagtgc aacaccagtg
ggaaccgcaa aaacagttat 4200gtgcggtacg tatccagtaa tccacgctgt
tggaccaaac ttctctaatt attcggagtc 4260tgaaggggac cgggaattgg
cagctgccta tcgagaagtc gcaaaggaag taactaggct 4320gggagtaaat
agtgtagcta tacctctcct ctccacaggt gtatactcag gagggaaaga
4380caggctgacc cagtcactga accacctctt tacagccatg gactcgacgg
atgcagacgt 4440ggtcatctac tgccgcgaca aagaatggga gaagaaaata
tctgaggcca tacagatgcg 4500gacccaagta gagctgctgg atgagcacat
ctccatagac tgcgatattg ttcgcgtgca 4560ccctgacagc agcttggcag
gcagaaaagg atacagcacc acggaaggcg cactgtactc 4620atatctagaa
gggacccgtt ttcatcagac ggctgtggat atggcggaga tacatactat
4680gtggccaaag caaacagagg ccaatgagca agtctgccta tatgccctgg
gggaaagtat 4740tgaatcgatc aggcagaaat gcccggtgga tgatgcagac
gcatcatctc cccccaaaac 4800tgtcccgtgc ctttgccgtt acgctatgac
tccagaacgc gtcacccggc ttcgcatgaa 4860ccacgtcaca agcataattg
tgtgttcttc gtttcccctc ccaaagtaca aaatagaagg 4920agtgcaaaaa
gtcaaatgct ctaaggtaat gctatttgac cacaacgtgc catcgcgcgt
4980aagtccaagg gaatatagat cttcccagga gtctgcacag gaggcgagta
caatcacgtc 5040actgacgcat agtcaattcg acctaagcgt tgatggcgag
atactgcccg tcccgtcaga 5100cctggatgct gacgccccag ccctagaacc
agcactagac gacggggcga cacacacgct 5160gccatccaca accggaaacc
ttgcggccgt gtctgattgg gtaatgagca ccgtacctgt 5220cgcgccgccc
agaagaaggc gagggagaaa cctgactgtg acatgtgacg agagagaagg
5280gaatataaca cccatggcta gcgtccgatt ctttagggca gagctgtgtc
cggtcgtaca 5340agaaacagcg gagacgcgtg acacagcaat gtctcttcag
gcaccaccga gtaccgccac 5400ggaaccgaat catccgccga tctccttcgg
agcatcaagc gagacgttcc ccattacatt 5460tggggacttc aacgaaggag
aaatcgaaag cttgtcttct gagctactaa ctttcggaga 5520cttcttacca
ggagaagtgg atgacttgac agacagcgac tggtccacgt gctcagacac
5580ggacgacgag ttatgactag acagggcagg tgggtatata ttctcgtcgg
acaccggtcc 5640aggtcattta caacagaagt cagtacgcca gtcagtgctg
ccggtgaaca ccctggagga 5700agtccacgag gagaagtgtt acccacctaa
gctggatgaa gcaaaggagc aactattact 5760taagaaactc caggagagtg
catccatggc caacagaagc aggtatcagt cgcgcaaagt 5820agaaaacatg
aaagcagcaa tcatccagag actaaagaga ggctgtagac tatacttaat
5880gtcagagacc ccaaaagtcc ctacttaccg gactacatat ccggcgcctg
tgtactcgcc 5940tccgatcaac gtccgattgt ccaatcccga gtccgcagtg
gcagcatgca atgagttctt 6000agctagaaac tatccaactg tctcatcata
ccaaattacc gacgagtatg atgcatatct 6060agacatggtg gacgggtcgg
agagttgcct ggaccgagcg acattcaatc cgtcaaaact 6120caggagctac
ccgaaacagc acgcttacca cgcgccctcc atcagaagcg ctgtaccgtc
6180cccattccag aacacactac agaatgtact ggcagcagcc acgaaaagaa
actgcaacgt 6240cacacagatg agggaattac ccactttgga ctcagcagta
ttcaacgtgg agtgtttcaa 6300aaaattcgca tgcaaccaag aatactggga
agaatttgct gccagcccta ttaggataac 6360aactgagaat ttagcaacct
atgttactaa actaaaaggg ccaaaagcag cagcgctatt 6420cgcaaaaacc
cataatctac tgccactaca ggaagtacca atggataggt tcacagtaga
6480tatgaaaagg gacgtaaagg tgactcctgg tacaaagcat acagaggaaa
gacctaaggt 6540gcaggttata caggcggctg aacccttggc gacagcatac
ctatgtggga ttcacagaga 6600gctggttagg aggctgaacg ccgtcctcct
acccaatgta catacactat ttgacatgtc 6660tgccgaggat ttcgatgcca
tcatagccgc acactttaag ccaggagaca ctgttttgga 6720aacggacata
gcctcctttg ataagagcca agatgattca cttgcgctta ctgctttgat
6780gctgttagag gatttagggg tggatcactc cctgctggac ttgatagagg
ctgctttcgg 6840agagatttcc agctgtcacc taccgacagg tacgcgcttc
aagttcggcg ccatgatgaa 6900atcaggtatg ttcctaactc tgttcgtcaa
cacattgtta aacatcacca tcgccagccg 6960agtgctggaa gatcgtctga
caaaatccgc gtgcgcggcc ttcatcggcg acgacaacat 7020aatacatgga
gtcgtctccg atgaattgat ggcagccaga tgtgccactt ggatgaacat
7080ggaagtgaag atcatagatg cagttgtatc cttgaaagcc ccttactttt
gtggagggtt 7140tatactgcac gatactgtga caggaacagc ttgcagagtg
gcagacccgc taaaaaggct 7200ttttaaactg ggcaaaccgc tagcggcagg
tgacgaacaa gatgaagata gaagacgagc 7260gctggctgac gaagtgatca
gatggcaacg aacagggcta attgatgagc tggagaaagc 7320ggtatactct
aggtacgaag tgcagggtat atcagttgtg gtaatgtcca tggccacctt
7380tgcaagctcc agatccaact tcgagaagct cagaggaccc gtcataactt
tgtacggcgg 7440tcctaaatag gtacgcacta cagctaccta ttttgcagaa
gccgacagca agtatctaaa 7500cactaatcag ctacaatgga gttcatccca
acccaaactt tttacaatag gaggtaccag 7560cctcgaccct ggactccgcg
ccctactatc caagtcatca ggcccagacc gcgccctcag 7620aggcaagctg
ggcaacttgc ccagctgatc tcagcagtta ataaactgac aatgcgcgcg
7680gtaccccaac agaagccacg caggaatcgg aagaataaga agcaaaagca
aaaacaacag 7740gcgccacaaa acaacacaaa tcaaaagaag cagccaccta
aaaagaaacc ggctcaaaag 7800aaaaagaagc cgggccgcag agagaggatg
tgcatgaaaa tcgaaaatga ttgtattttc 7860gaagtcaagc acgaaggtaa
ggtaacaggt tacgcgtgcc tggtggggga caaagtaatg 7920aaaccagcac
acgtaaaggg gaccatcgat aacgcggacc tggccaaact ggcctttaag
7980cggtcatcta agtatgacct tgaatgcgcg cagatacccg tgcacatgaa
gtccgacgct 8040tcgaagttca cccatgagaa accggagggg tactacaact
ggcaccacgg agcagtacag 8100tactcaggag gccggttcac catccctaca
ggtgctggca aaccagggga cagcggcaga 8160ccgatcttcg acaacaaggg
acgcgtggtg gccatagtct taggaggagc taatgaagga 8220gcccgtacag
ccctctcggt ggtgacctgg aataaagaca ttgtcactaa aatcaccccc
8280gagggggccg aagagtggag tcttgccatc ccagttatgt gcctgttggc
aaacaccacg 8340ttcccctgct cccagccccc ttgcacgccc tgctgctacg
aaaaggaacc ggaggaaacc 8400ctacgcatgc ttgaggacaa cgtcatgaga
cctgggtact atcagctgct acaagcatcc 8460ttaacatgtt ctccccaccg
ccagcgacgc agcaccaagg acaacttcaa tgtctataaa 8520gccacaagac
catacttagc tcactgtccc gactgtggag aagggcactc gtgccatagt
8580cccgtagcac tagaacgcat cagaaatgaa gcgacagacg ggacgctgaa
aatccaggtc 8640tccttgcaaa tcggaataaa gacggatgac agccacgatt
ggaccaagct gcgttatatg 8700gacaaccaca tgccagcaga cgcagagagg
gcggggctat ttgtaagaac atcagcaccg 8760tgtacgatta ctggaacaat
gggacacttc atcctggccc gatgtccaaa aggggaaact 8820ctgacggtgg
gattcactga cagtaggaag attagtcact catgtacgca cccatttcac
8880cacgaccctc ctgtgatagg tcgggaaaaa ttccattccc gaccgcagca
cggtaaagag 8940ctaccttgca gcacgtacgt gcagagcacc gccgcaacta
ccgaggagat agaggtacac 9000atgcccccag acacccctga tcgcacatta
atgtcacaac agtccggcaa cgtaaagatc 9060acagtcaatg gccagacggt
gcggtacaag tgtaattgcg gtggctcaaa tgaaggacta 9120acaactacag
acaaagtgat taataactgc aaggttgatc aatgtcatgc cgcggtcacc
9180aatcacaaaa agtggcagta taactcccct ctggtcccgc gtaatgctga
acttggggac 9240cgaaaaggaa aaattcacat cccgtttccg ctggcaaatg
taacatgcag ggtgcctaaa 9300gcaaggaacc ccaccgtgac gtacgggaaa
aaccaagtca tcatgctact gtatcctgac 9360cacccaacac tcctgtccta
ccggaatatg ggagaagaac caaactatca agaagagtgg 9420gtgatgcata
agaaggaagt cgtgctaacc gtgccgactg aagggctcga ggtcacgtgg
9480ggcaacaacg agccgtataa gtattggccg cagttatcta caaacggtac
agcccatggc 9540cacccgcacg agataattct gtattattat gagctgtacc
ccactatgac tgtagtagtt 9600gtgtcagtgg ccacgttcat actcctgtcg
atggtgggta tggcagcggg gatgtgcatg 9660tgtgcacgac gcagatgcat
cacaccgtat gaactgacac caggagctac cgtccctttc 9720ctgcttagcc
taatatgctg catcagaaca gctaaagcgg ccacatacca agaggctgcg
9780atatacctgt ggaacgagca gcaacctttg ttttggctac aagcccttat
tccgctggca 9840gccctgattg ttctatgcaa ctgtctgaga ctcttaccat
gctgctgtaa aacgttggct 9900tttttagccg taatgagcgt cggtgcccac
actgtgagcg cgtacgaaca cgtaacagtg 9960atcccgaaca cggtgggagt
accgtataag actctagtca atagacctgg ctacagcccc 10020atggtattgg
agatggaact actgtcagtc actttggagc caacactatc gcttgattac
10080atcacgtgcg agtacaaaac cgtcatcccg tctccgtacg tgaagtgctg
cggtacagca 10140gagtgcaagg acaaaaacct acctgactac agctgtaagg
tcttcaccgg cgtctaccca 10200tttatgtggg gcggcgccta ctgcttctgc
gacgctgaaa acacgcagtt gagcgaagca 10260cacgtggaga agtccgaatc
atgcaaaaca gaatttgcat cagcatacag ggctcatacc 10320gcatctgcat
cagctaagct ccgcgtcctt taccaaggaa ataacatcac tgtaactgcc
10380tatgcaaacg gcgaccatgc cgtcacagtt aaggacgcca aattcattgt
ggggccaatg 10440tcttcagcct ggacaccttt cgacaacaaa attgtggtgt
acaaaggtga cgtctataac 10500atggactacc cgccctttgg cgcaggaaga
ccaggacaat ttggcgatat ccaaagtcgc 10560acacctgaga gtaaagacgt
ctatgctaat acacaactgg tactgcagag accggctgtg 10620ggtacggtac
acgtgccata ctctcaggca ccatctggct ttaagtattg gctaaaagaa
10680cgcggggcgt cgctgcagca cacagcacca tttggctgcc aaatagcaac
aaacccggta 10740agagcggtga actgcgccgt agggaacatg cccatctcca
tcgacatacc ggaagcggcc 10800ttcactaggg tcgtcgacgc gccctcttta
acggacatgt cgtgcgaggt accagcctgc 10860acccattcct cagactttgg
gggcgtcgcc attattaaat atgcagccag caagaaaggc 10920aagtgtgcgg
tgcattcgat gactaacgcc gtcactattc gggaagctga gatagaagtt
10980gaagggaatt ctcagctgca aatctctttc tcgacggcct tagccagcgc
cgaattccgc 11040gtacaagtct gttctacaca agtacactgt gcagccgagt
gccacccccc gaaggaccac 11100atagtcaact acccggcgtc acataccacc
ctcggggtcc aggacatctc cgctacggcg 11160atgtcatggg tgcagaagat
cacgggaggt gtgggactgg ttgttgctgt tgccgcactg 11220attctaatcg
tggtgctatg cgtgtcgttc agcaggcact aacttgacaa ttaagtatga
11280aggtatatgt gtcccctaag agacacactg tacatagcaa ataatctata
gatcaaaggg 11340ctacgcaacc cctgaatagt aacaaaatat aaaatcacta
aaaattataa aaacagaaaa 11400atacataaat aggtatacgt gtcccctaag
agacacattg tatgtaggtg ataagtatag 11460atcaaagggc cgaataaccc
ctgaatagta acaaaatatg aaaatcaata aaaatcataa 11520aatagaaaaa
ccataaacag aagtagttca aagggctata aaacccctga atagtaacaa
11580aacataaaat taataaaaat c 11601611237DNAChikungunya virus
6cagtttctta ctgctctact ctgcaaagca agagattaat aacccatcat ggatcctgtg
60tacgtggaca tagacgctga cagcgccttt ttgaaggccc tgcaacgtgc gtaccccatg
120tttgaggtgg aaccaaggca ggtcacaccg aatgaccatg ctaatgctag
agcgttctcg 180catctagcta taaaactaat agagcaggaa attgaccccg
actcaaccat cctggatatc 240ggcagtgcgc cagcaaggag gatgatgtcg
gacaggaagt accactgcgt ctgcccgatg 300cgcagtgcgg aagatcccga
gagactcgcc aattatgcga gaaagctagc atctgccgca 360ggaaaagtcc
tggacagaaa catctctgga aagatcgggg acttacaagc agtaatggcc
420gtgccagaca cggagacgcc aacattctgc ttacacacag acgtctcatg
tagacagaga 480gcagacgtcg ctatatacca agacgtctat gctgtacacg
cacccacgtc gctataccac 540caggcgatta aaggggtccg agtggcgtac
tgggttgggt tcgacacaac cccgttcatg 600tacaatgcca tggcgggtgc
ctacccctca tactcgacaa actgggcaga tgagcaggta 660ctgaaggcta
agaacatagg attatgttca acagacctga cggaaggtag acgaggcaag
720ttgtctatta tgagagggaa aaagctaaaa ccgtgcgacc gtgtgctgtt
ctcagtaggg 780tcaacgctct acccggaaag ccgcaagcta cttaagagct
ggcacctgcc atcggtgttc 840catttaaagg gcaaactcag cttcacatgc
cgctgtgata cagtggtttc gtgtgagggc 900tacgtcgtta agagaataac
gatgagccca ggcctttatg gaaaaaccac agggtatgcg 960gtaacccacc
acgcagacgg attcctgatg tgcaagacta ccgacacggt tgacggcgaa
1020agagtgtcat tctcggtgtg cacatacgtg ccggcgacca tttgtgatca
aatgaccggc 1080atccttgcta cagaagtcac gccggaggat gcacagaagc
tgttggtggg gctgaaccag 1140agaatagtgg ttaacggcag aacgcaacgg
aatacgaaca ccatgaaaaa ttatctgctt 1200cccgtggtcg cccaagcctt
cagtaagtgg gcaaaggagt gccggaaaga catggaagat 1260gaaaaactcc
tgggggtcag agaaagaaca ctgacctgct gctgtctatg ggcattcaag
1320aagcagaaaa cacacacggt ctacaagagg cctgataccc agtcaattca
gaaggttcag 1380gccgagtttg acagctttgt ggtaccgagt ctgtggtcgt
ccgggttgtc aatccctttg 1440aggactagaa tcaaatggtt gttaagcaag
gtgccaaaaa ccgacctgat cccatacagc 1500ggagacgccc gagaagcccg
ggacgcagaa aaagaagcag aggaagaacg agaagcagaa 1560ctgactcgcg
aagccctacc acctctacag gcagcacagg aagatgttca ggtcgaaatc
1620gacgtggaac agcttgagga cagagcgggc gcaggaataa tagagactcc
gagaggagct 1680atcaaagtta ctgcccaacc aacagaccac gtcgtgggag
agtacctggt actctccccg 1740cagaccgtac tacgtagcca gaagctcagt
ctgattcacg ctttggcgga gcaagtgaag 1800acgtgcacgc acaacggacg
agcagggagg tatgcggtcg aagcgtacga cggccgagtc
1860ctagtgccct caggctatgc aatctcgcct gaagacttcc agagtctaag
cgaaagcgca 1920acgatggtgt ataacgaaag agagttcgta aacagaaagc
tacaccatat tgcgatgcac 1980ggaccagccc tgaacaccga cgaagagtcg
tatgagctgg tgagggcaga gaggacagaa 2040cacgagtacg tctacgacgt
ggatcagaga agatgctgta agaaggaaga agccgcagga 2100ctggtactgg
tgggcgactt gactaatccg ccctaccacg aattcgcata tgaagggcta
2160aaaatccgcc ctgcctgccc atacaaaatt gcagtcatag gagtcttcgg
agtaccggga 2220tctggcaagt cagctattat caagaaccta gttaccaggc
aggacctggt gactagcgga 2280aagaaagaaa actgccaaga aatcaccacc
gacgtgatga gacagagagg tctagagata 2340tctgcacgta cggttgactc
gctgctcttg aatggatgca acagaccagt cgacgtgttg 2400tacgtagacg
aggcgtttgc gtgccactct ggaacgctac ttgctttgat cgccttggtg
2460agaccaaggc agaaagttgt actttgtggt gacccgaagc agtgcggctt
cttcaatatg 2520atgcagatga aagtcaacta taatcacaac atctgcaccc
aagtgtacca caaaagtatc 2580tccaggcggt gtacactgcc tgtgaccgcc
attgtgtcat cgttgcatta cgaaggcaaa 2640atgcgcacta cgaatgagta
caacaagccg attgtagtgg acactacagg ctcaacaaaa 2700cctgaccctg
gagacctcgt gttaacgtgc ttcagagggt gggttaaaca actgcaaatt
2760gactatcgtg gatacgaggt catgacagca gccgcatccc aagggttaac
cagaaaagga 2820gtttacgcag ttagacaaaa agttaatgaa aacccgctct
atgcatcaac gtcagagcac 2880gtcaacgtac tcctaacgcg tacggaaggt
aaactggtat ggaagacact ttccggcgac 2940ccgtggataa agacgctgca
gaacccaccg aaaggaaact tcaaagcaac tattaaggag 3000tgggaggtgg
agcatgcatc aataatggcg ggcatctgca gtcaccaaat gaccttcgat
3060acattccaaa ataaagccaa cgtttgttgg gctaagagct tggtccctat
cctcgaaaca 3120gcggggataa aactaaatga taggcagtgg tctcagataa
ttcaagcctt caaagaagac 3180aaagcatact cacctgaagt agccctgaat
gaaatatgta cgcgcatgta tggggtggat 3240ctagacagcg ggctattttc
taaaccgttg gtgtctgtgt attacgcgga taaccactgg 3300gataataggc
ctggagggaa aatgttcgga tttaaccccg aggcagcatc cattctagaa
3360agaaagtatc cattcacaaa agggaagtgg aacatcaaca agcagatctg
cgtgactacc 3420aggaggatag aagactttaa ccctaccacc aacatcatac
cggccaacag gagactacca 3480cactcattag tggccgaaca ccgcccagta
aaaggggaaa gaatggaatg gctggttaac 3540aagataaacg gccaccacgt
gctcctggtc agtggctata accttgcact gcctactaag 3600agagtcactt
gggtagcgcc gttaggtgtc cgcggagcgg actacacata caacctagag
3660ttgggtctgc cagcaacgct tggtaggtat gacctagtgg tcataaacat
ccacacacct 3720tttcgcatac accattacca acagtgcgtc gaccacgcaa
tgaaactgca aatgctcggg 3780ggtgactcat tgagactgct caaaccgggc
ggctctctat tgatcagagc atatggttac 3840gcagatagaa ccagtgaacg
agtcatctgc gtattgggac gcaagtttag atcgtctaga 3900gcgttgaaac
caccatgtgt caccagcaac actgagatgt ttttcctatt cagcaacttt
3960gacaatggca gaaggaattt cacaactcat gtcatgaaca atcaactgaa
tgcagccttc 4020gtaggacagg tcacccgagc aggatgtgca ccgtcgtacc
gggtaaaacg catggacatc 4080gcgaagaacg atgaagagtg cgtagtcaac
gccgctaacc ctcgcgggtt accgggtgac 4140ggtgtttgca aggcagtata
caaaaaatgg ccggagtcct ttaagaacag tgcaacacca 4200gtgggaaccg
caaaaacagt tatgtgcggt acgtatccag taatccacgc tgttggacca
4260aacttctcta attattcgga gtctgaaggg gaccgggaat tggcagctgc
ctatcgagaa 4320gtcgcaaagg aagtaactag gctgggagta aatagtgtag
ctatacctct cctctccaca 4380ggtgtatact caggagggaa agacaggctg
acccagtcac tgaaccacct ctttacagcc 4440atggactcga cggatgcaga
cgtggtcatc tactgccgcg acaaagaatg ggagaagaaa 4500atatctgagg
ccatacagat gcggacccaa gtagagctgc tggatgagca catctccata
4560gactgcgata ttgttcgcgt gcaccctgac agcagcttgg caggcagaaa
aggatacagc 4620accacggaag gcgcactgta ctcatatcta gaagggaccc
gttttcatca gacggctgtg 4680gatatggcgg agatacatac tatgtggcca
aagcaaacag aggccaatga gcaagtctgc 4740ctatatgccc tgggggaaag
tattgaatcg atcaggcaga aatgcccggt ggatgatgca 4800gacgcatcat
ctccccccaa aactgtcccg tgcctttgcc gttacgctat gactccagaa
4860cgcgtcaccc ggcttcgcat gaaccacgtc acaagcataa ttgtgtgttc
ttcgtttccc 4920ctcccaaagt acaaaataga aggagtgcaa aaagtcaaat
gctctaaggt aatgctattt 4980gaccacaacg tgccatcgcg cgtaagtcca
agggaatata gatcttccca ggagtctgca 5040caggaggcga gtacaatcac
gtcactgacg catagtcaat tcgacctaag cgttgatggc 5100gagatactgc
ccgtcccgtc agacctggat gctgacgccc cagccctaga accagcacta
5160gacgacgggg cgacacacac gctgccatcc acaaccggaa accttgcggc
cgtgtctaga 5220cagggcaggt gggtatatat tctcgtcgga caccggtcca
ggtcatttac aacagaagtc 5280agtacgccag tcagtgctgc cggtgaacac
cctggaggaa gtccacgagg agaagtgtta 5340cccacctaag ctggatgaag
caaaggagca actattactt aagaaactcc aggagagtgc 5400atccatggcc
aacagaagca ggtatcagtc gcgcaaagta gaaaacatga aagcagcaat
5460catccagaga ctaaagagag gctgtagact atacttaatg tcagagaccc
caaaagtccc 5520tacttaccgg actacatatc cggcgcctgt gtactcgcct
ccgatcaacg tccgattgtc 5580caatcccgag tccgcagtgg cagcatgcaa
tgagttctta gctagaaact atccaactgt 5640ctcatcatac caaattaccg
acgagtatga tgcatatcta gacatggtgg acgggtcgga 5700gagttgcctg
gaccgagcga cattcaatcc gtcaaaactc aggagctacc cgaaacagca
5760cgcttaccac gcgccctcca tcagaagcgc tgtaccgtcc ccattccaga
acacactaca 5820gaatgtactg gcagcagcca cgaaaagaaa ctgcaacgtc
acacagatga gggaattacc 5880cactttggac tcagcagtat tcaacgtgga
gtgtttcaaa aaattcgcat gcaaccaaga 5940atactgggaa gaatttgctg
ccagccctat taggataaca actgagaatt tagcaaccta 6000tgttactaaa
ctaaaagggc caaaagcagc agcgctattc gcaaaaaccc ataatctact
6060gccactacag gaagtaccaa tggataggtt cacagtagat atgaaaaggg
acgtgaaggt 6120gactcctggt acaaagcata cagaggaaag acctaaggtg
caggttatac aggcggctga 6180acccttggcg acagcatacc tatgtgggat
tcacagagag ctggttagga ggctgaacgc 6240cgtcctccta cccaatgtac
atacactatt tgacatgtct gccgaggatt tcgatgccat 6300catagccgca
cactttaagc caggagacac tgttttggaa acggacatag cctcctttga
6360taagagccaa gatgattcac ttgcgcttac tgctttgatg ctgttagagg
atttaggggt 6420ggatcactcc ctgctggact tgatagaggc tgctttcgga
gagatttcca gctgtcacct 6480accgacaggt acgcgcttca agttcggcgc
catgatgaaa tcaggtatgt tcctaactct 6540gttcgtcaac acattgttaa
acatcaccat cgccagccga gtgctggaag atcgtctgac 6600aaaatccgcg
tgcgcggcct tcatcggcga cgacaacata atacatggag tcgtctccga
6660tgaattgatg gcagccagat gtgccacttg gatgaacatg gaagtgaaga
tcatagatgc 6720agttgtatcc ttgaaagccc cttacttttg tggagggttt
atactgcacg atactgtgac 6780aggaacagct tgcagagtgg cagacccgct
aaaaaggctt tttaaactgg gcaaaccgct 6840agcggcaggt gacgaacaag
atgaagatag aagacgagcg ctggctgacg aagtgatcag 6900atggcaacga
acagggctaa ttgatgagct ggagaaagcg gtatactcta ggtacgaagt
6960gcagggtata tcagttgtgg taatgtccat ggccaccttt gcaagctcca
gatccaactt 7020cgagaagctc agaggacccg tcataacttt gtacggcggt
cctaaatagg tacgcactac 7080agctacctat tttgcagaag ccgacagcaa
gtatctaaac actaatcagc tacaatggag 7140ttcatcccaa cccaaacttt
ttacaatagg aggtaccagc ctcgaccctg gactccgcgc 7200cctactatcc
aagtcatcag gcccagaccg cgccctcaga ggcaagctgg gcaacttgcc
7260cagctgatct cagcagttaa taaactgaca atgcgcgcgg taccccaaca
gaagccacgc 7320aggaatcgga agaataagaa gcaaaagcaa aaacaacagg
cgccacaaaa caacacaaat 7380caaaagaagc agccacctaa aaagaaaccg
gctcaaaaga aaaagaagcc gggccgcaga 7440gagaggatgt gcatgaaaat
cgaaaatgat tgtattttcg aagtcaagca cgaaggtaag 7500gtaacaggtt
acgcgtgcct ggtgggggac aaagtaatga aaccagcaca cgtaaagggg
7560accatcgata acgcggacct ggccaaactg gcctttaagc ggtcatctaa
gtatgacctt 7620gaatgcgcgc agatacccgt gcacatgaag tccgacgctt
cgaagttcac ccatgagaaa 7680ccggaggggt actacaactg gcaccacgga
gcagtacagt actcaggagg ccggttcacc 7740atccctacag gtgctggcaa
accaggggac agcggcagac cgatcttcga caacaaggga 7800cgcgtggtgg
ccatagtctt aggaggagct aatgaaggag cccgtacagc cctctcggtg
7860gtgacctgga ataaagacat tgtcactaaa atcacccccg agggggccga
agagtggagt 7920cttgccatcc cagttatgtg cctgttggca aacaccacgt
tcccctgctc ccagccccct 7980tgcacgccct gctgctacga aaaggaaccg
gaggaaaccc tacgcatgct tgaggacaac 8040gtcatgagac ctgggtacta
tcagctgcta caagcatcct taacatgttc tccccaccgc 8100cagcgacgca
gcaccaagga caacttcaat gtctataaag ccacaagacc atacttagct
8160cactgtcccg actgtggaga agggcactcg tgccatagtc ccgtagcact
agaacgcatc 8220agaaatgaag cgacagacgg gacgctgaaa atccaggtct
ccttgcaaat cggaataaag 8280acggatgaca gccacgattg gaccaagctg
cgttatatgg acaaccacat gccagcagac 8340gcagagaggg cggggctatt
tgtaagaaca tcagcaccgt gtacgattac tggaacaatg 8400ggacacttca
tcctggcccg atgtccaaaa ggggaaactc tgacggtggg attcactgac
8460agtaggaaga ttagtcactc atgtacgcac ccatttcacc acgaccctcc
tgtgataggt 8520cgggaaaaat tccattcccg accgcagcac ggtaaagagc
taccttgcag cacgtacgtg 8580cagagcaccg ccgcaactac cgaggagata
gaggtacaca tgcccccaga cacccctgat 8640cgcacattaa tgtcacaaca
gtccggcaac gtaaagatca cagtcaatgg ccagacggtg 8700cggtacaagt
gtaattgcgg tggctcaaat gaaggactaa caactacaga caaagtgatt
8760aataactgca aggttgatca atgtcatgcc gcggtcacca atcacaaaaa
gtggcagtat 8820aactcccctc tggtcccgcg taatgctgaa cttggggacc
gaaaaggaaa aattcacatc 8880ccgtttccgc tggcaaatgt aacatgcagg
gtgcctaaag caaggaaccc caccgtgacg 8940tacgggaaaa accaagtcat
catgctactg tatcctgacc acccaacact cctgtcctac 9000cggaatatgg
gagaagaacc aaactatcaa gaagagtggg tgatgcataa gaaggaagtc
9060gtgctaaccg tgccgactga agggctcgag gtcacgtggg gcaacaacga
gccgtataag 9120tattggccgc agttatctac aaacggtaca gcccatggcc
acccgcatga gataattctg 9180tattattatg agctgtaccc cactatgact
gtagtagttg tgtcagtggc cacgttcata 9240ctcctgtcga tggtgggtat
ggcagcgggg atgtgcatgt gtgcacgacg cagatgcatc 9300acaccgtatg
aactgacacc aggagctacc gtccctttcc tgcttagcct aatatgctgc
9360atcagaacag ctaaagcggc cacataccaa gaggctgcga tatacctgtg
gaacgagcag 9420caacctttgt tttggctaca agcccttatt ccgctggcag
ccctgattgt tctatgcaac 9480tgtctgagac tcttaccatg ctgctgtaaa
acgttggctt ttttagccgt aatgagcgtc 9540ggtgcccaca ctgtgagcgc
gtacgaacac gtaacagtga tcccgaacac ggtgggagta 9600ccgtataaga
ctctagtcaa tagacctggc tacagcccca tggtattgga gatggaacta
9660ctgtcagtca ctttggagcc aacactatcg cttgattaca tcacgtgcga
gtacaaaacc 9720gtcatcccgt ctccgtacgt gaagtgctgc ggtacagcag
agtgcaagga caaaaaccta 9780cctgactaca gctgtaaggt cttcaccggc
gtctacccat ttatgtgggg cggcgcctac 9840tgcttctgcg acgctgaaaa
cacgcagttg agcgaagcac acgtggagaa gtccgaatca 9900tgcaaaacag
aatttgcatc agcatacagg gctcataccg catctgcatc agctaagctc
9960cgcgtccttt accaaggaaa taacatcact gtaactgcct atgcaaacgg
cgaccatgcc 10020gtcacagtta aggacgccaa attcattgtg gggccaatgt
cttcagcctg gacacctttc 10080gacaacaaaa ttgtggtgta caaaggtgac
gtctataaca tggactaccc gccctttggc 10140gcaggaagac caggacaatt
tggcgatatc caaagtcgca cacctgagag taaagacgtc 10200tatgctaata
cacaactggt actgcagaga ccggctgcgg gtacggtaca cgtgccatac
10260tctcaggcac catctggctt taagtattgg ctaaaagaac gcggggcgtc
gctgcagcac 10320acagcaccat ttggctgcca aatagcaaca aacccggtaa
gagcggtgaa ctgcgccgta 10380gggaacatgc ccatctccat cgacataccg
gaagcggcct tcactagggt cgtcgacgcg 10440ccctctttaa cggacatgtc
gtgcgaggta ccagcctgca cccattcctc agactttggg 10500ggcgtcgcca
ttattaaata tgcagccagc aagaaaggca agtgtgcggt gcattcgatg
10560actaacgccg tcactattcg ggaagctgag atagaagttg aagggaattc
tcagctgcaa 10620atctctttct cgacggcctt agccagcgcc gaattccgcg
tacaagtctg ttctacacaa 10680gtacactgtg cagccgagtg ccaccccccg
aaggaccaca tagtcaacta cccggcgtca 10740cataccaccc tcggggtcca
ggacatctcc gctacggcga tgtcatgggt gcagaagatc 10800acgggaggtg
tgggactggt tgttgctgtt gccgcactga ttctaatcgt ggtgctatgc
10860gtgtcgttca gcaggcacta acttgacaat taagtatgaa ggtatatgtg
tcccctaaga 10920gacacactgt acatagcaaa taatctatag atcaaagggc
tacgcaaccc ctgaatagta 10980acaaaataca aaatcactaa aaattataaa
aacagaaaaa tacataaata ggtatacgtg 11040tcccctaaga gacacattgt
atgtaggtga taagtataga tcaaagggcc gaataacccc 11100tgaatagtaa
caaaatatga aaatcaataa aaatcataaa atagaaaaac cataaacaga
11160agtagttcaa agggctataa aacccctgaa tagtaacaaa acataaaatt
aataaaaatc 11220aaatgaatac catatgg 1123771797DNAChikungunya virus
7atacccgtgc acatgaagtc cgacgcttcg aagttcaccc atgagaaacc ggaggggtac
60tacaactggc accacggagc agtacagtac tcaggaggcc ggttcaccat ccctacaggt
120gctggcaaac caggggacag cggcagaccg atcttcgaca acaagggacg
cgtggtggcc 180atagtcttag gaggagctaa tgaaggagcc cgtacagccc
tctcggtggt gacctggaat 240aaagacattg tcactaaaat cacccccgag
ggggccgaag agtggagtct tgccatccca 300gttatgtgcc tgttggcaaa
caccacgttc ccctgctccc agcccccttg cacgccctgc 360tgctacgaaa
aggaaccgga ggaaacccta cgcatgcttg aggacaacgt catgagacct
420gggtactatc agctgctaca agcatcctta acatgttctc cccaccgcca
gcgacgcagc 480accaaggaca acttcaatgt ctataaagcc acaagaccat
acttagctca ctgtcccgac 540tgtggagaag ggcactcgtg ccatagtccc
gtagcactag aacgcatcag aaatgaagcg 600acagacggga cgctgaaaat
ccaggtctcc ttgcaaatcg gaataaagac ggatgacagc 660cacgattgga
ccaagctgcg ttatatggac aaccacatgc cagcagacgc agagagggcg
720gggctatttg taagaacatc agcaccgtgt acgattactg gaacaatggg
acacttcatc 780ctggcccgat gtccaaaagg ggaaactctg acggtgggat
tcactgacag taggaagatt 840agtcactcat gtacgcaccc atttcaccac
gaccctcctg tgataggtcg ggaaaaattc 900cattcccgac cgcagcacgg
taaagagcta ccttgcagca cgtacgtgca gagcaccgcc 960gcaactaccg
aggagataga ggtacacatg cccccagaca cccctgatcg cacattaatg
1020tcacaacagt ccggcaacgt aaagatcaca gtcaatggcc agacggtgcg
gtacaagtgt 1080aattgcggtg gctcaaatga aggactaaca actacagaca
aagtgattaa taactgcaag 1140gttgatcaat gtcatgccgc ggtcaccaat
cacaaaaagt ggcagtataa ctcccctctg 1200gtcccgcgta atgctgaact
tggggaccga aaaggaaaaa ttcacatccc gtttccgctg 1260gcaaatgtaa
catgcagggt gcctaaagca aggaacccca ccgtgacgta cgggaaaaac
1320caagtcatca tgctactgta tcctgaccac ccaacactcc tgtcctaccg
gaatatggga 1380gaagaaccaa actatcaaga agagtgggtg atgcataaga
aggaagtcgt gctaaccgtg 1440ccgactgaag ggctcgaggt cacgtggggc
aacaacgagc cgtataagta ttggccgcag 1500ttatctacaa acggtacagc
ccatggccac ccgcatgaga taattctgta ttattatgag 1560ctgtacccca
ctatgactgt agtagttgtg tcagtggcca cgttcatact cctgtcgatg
1620gtgggtatgg cagcggggat gtgcatgcgt gcacgacgca gatgcatcac
accgtatgaa 1680ctgacaccag gagctaccgt ccctttcctg cttagcctaa
tatgctgcat cagaacagct 1740aaagcggcca cataccaaga ggctgcgata
tacctgtgga acgagcagca accttta 179781797DNAChikungunya virus
8atacccgtgc acatgaagtc cgacgcttcg aagttcaccc atgagaaacc ggaggggtac
60tacaactggc accacggagc agtacagtac tcaggaggcc ggttcaccat ccctacaggt
120gctggcaaac caggggacag cggcagaccg atcttcgaca acaagggacg
cgtggtggcc 180atagtcttag gaggagctaa tgaaggagcc cgtacagccc
tctcggtggt gacctggaat 240aaagacattg tcactaaaat cacccccgag
ggggccgaag agtggagtct tgccatccca 300gttatgtgcc tgttggcaaa
caccacgttc ccctgctccc agcccccttg cacgccctgc 360tgctacgaaa
aggaaccgga ggaaacccta cgcatgcttg aggacaacgt catgagacct
420gggtactatc agctgctaca agcatcctta acatgttctc cccaccgcca
gcgacgcagc 480accaaggaca acttcaatgt ctataaagcc acaagaccat
acttagctca ctgtcccgac 540tgtggagaag ggcactcgtg ccatagtccc
gtagcactag aacgcatcag aaatgaagcg 600acagacggga cgctgaaaat
ccaggtctcc ttgcaaatcg gaataaagac ggatgacagc 660cacgattgga
ccaagctgcg ttatatggac aaccacatgc cagcagacgc agagagggcg
720gggctatttg taagaacatc agcaccgtgt acgattactg gaacaatggg
acacttcatc 780ctggcccgat gtccaaaagg ggaaactctg acggtgggat
tcactgacag taggaagatt 840agtcactcat gtacgcaccc atttcaccac
gaccctcctg tgataggtcg ggaaaaattc 900cattcccgac cgcagcacgg
taaagagcta ccttgcagca cgtacgtgca gagcaccgcc 960gcaactaccg
aggagataga ggtacacatg cccccagaca cccctgatcg cacattaatg
1020tcacaacagt ccggcaacgt aaagatcaca gtcaatggcc agacggtgcg
gtacaagtgt 1080aattgcggtg gctcaaatga aggactaaca actacagaca
aagtgattaa taactgcaag 1140gttgatcaat gtcatgccgc ggtcaccaat
cacaaaaagt ggcagtataa ctcccctctg 1200gtcccgcgta atgctgaact
tggggaccga aaaggaaaaa ttcacatccc gtttccgctg 1260gcaaatgtaa
catgcagggt gcctaaagca aggaacccca ccgtgacgta cgggaaaaac
1320caagtcatca tgctactgta tcctgaccac ccaacactcc tgtcctaccg
gaatatggga 1380gaagaaccaa actatcaaga agagtgggtg atgcataaga
aggaagtcgt gctaaccgtg 1440ccgactgaag ggctcgaggt cacgtggggc
aacaacgagc cgtataagta ttggccgcag 1500ttatctacaa acggtacagc
ccatggccac ccgcatgaga taattctgta ttattatgag 1560ctgtacccca
ctatgactgt agtagttgtg tcagtggcca cgttcatact cctgtcgatg
1620gtgggtatgg cagcggggat gtgcatgtgt gcacgacgca gatgcatcac
accgtatgaa 1680ctgacaccag gagctaccgt ccctttcctg cttagcctaa
tatgctgcat cagaacagct 1740aaagcggcca cataccaaga ggctgcgata
tacctgtgga acgagcagca accttta 179791797DNAChikungunya virus
9atacccgtgc acatgaagtc cgacgcttcg aagttcaccc atgagaaacc ggaggggtac
60tacaactggc accacggagc agtacagtac tcaggaggcc ggttcaccat ccctacaggt
120gctggcaaac caggggacag cggcagaccg atcttcgaca acaagggacg
cgtggtggcc 180atagtcttag gaggagctaa tgaaggagcc cgtacagccc
tctcggtggt gacctggaat 240aaagacattg tcactaaaat cacccccgag
ggggccgaag agtggagtct tgccatccca 300gttatgtgcc tgttggcaaa
caccacgttc ccctgctccc agcccccttg cacgccctgc 360tgctacgaaa
aggaaccgga ggaaacccta cgcatgcttg aggacaacgt catgagacct
420gggtactatc agctgctaca agcatcctta acatgttctc cccaccgcca
gcgacgcagc 480accaaggaca acttcaatgt ctataaagcc acaagaccat
acttagctca ctgtcccgac 540tgtggagaag ggcactcgtg ccatagtccc
gtagcactag aacgcatcag aaatgaagcg 600acagacggga cgctgaaaat
ccaggtctcc ttgcaaatcg gaataaagac ggatgacagc 660cacgattgga
ccaagctgcg ttatatggac aaccacatgc cagcagacgc agagagggcg
720gggctatttg taagaacatc agcaccgtgt acgattactg gaacaatggg
acacttcatc 780ctggcccgat gtccaaaagg ggaaactctg acggtgggat
tcactgacag taggaagatt 840agtcactcat gtacgcaccc atttcaccac
gaccctcctg tgataggtcg ggaaaaattc 900cattcccgac cgcagcacgg
taaagagcta ccttgcagca cgtacgtgca gagcaccgcc 960gcaactaccg
aggagataga ggtacacatg cccccagaca cccctgatcg cacattaatg
1020tcacaacagt ccggcaacgt aaagatcaca gtcaatggcc agacggtgcg
gtacaagtgt 1080aattgcggtg gctcaaatga aggactaaca actacagaca
aagtgattaa taactgcaag 1140gttgatcaat gtcatgccgc ggtcaccaat
cacaaaaagt ggcagtataa ctcccctctg 1200gtcccgcgta atgctgaact
tggggaccga aaaggaaaaa ttcacatccc gtttccgctg 1260gcaaatgtaa
catgcagggt gcctaaagca aggaacccca ccgtgacgta cgggaaaaac
1320caagtcatca tgctactgta tcctgaccac ccaacactcc tgtcctaccg
gaatatggga 1380gaagaaccaa actatcaaga agagtgggtg atgcataaga
aggaagtcgt gctaaccgtg 1440ccgactgaag ggctcgaggt cacgtggggc
aacaacgagc cgtataagta ttggccgcag 1500ttatctacaa acggtacagc
ccatggccac ccgcacgaga taattctgta ttattatgag 1560ctgtacccca
ctatgactgt agtagttgtg tcagtggcca cgttcatact cctgtcgatg
1620gtgggtatgg cagcggggat gtgcatgtgt gcacgacgca gatgcatcac
accgtatgaa 1680ctgacaccag gagctaccgt ccctttcctg cttagcctaa
tatgctgcat cagaacagct 1740aaagcggcca cataccaaga ggctgcgata
tacctgtgga acgagcagca accttta 1797101797DNAChikungunya virus
10atacccgtgc acatgaagtc cgacgcttcg aagttcaccc atgagaaacc ggaggggtac
60tacaactggc accacggagc agtacagtac tcaggaggcc ggttcaccat
ccctacaggt
120gctggcaaac caggggacag cggcagaccg atcttcgaca acaagggacg
cgtggtggcc 180atagtcttag gaggagctaa tgaaggagcc cgtacagccc
tctcggtggt gacctggaat 240aaagacattg tcactaaaat cacccccgag
ggggccgaag agtggagtct tgccatccca 300gttatgtgcc tgttggcaaa
caccacgttc ccctgctccc agcccccttg cacgccctgc 360tgctacgaaa
aggaaccgga ggaaacccta cgcatgcttg aggacaacgt catgagacct
420gggtactatc agctgctaca agcatcctta acatgttctc cccaccgcca
gcgacgcagc 480accaaggaca acttcaatgt ctataaagcc acaagaccat
acttagctca ctgtcccgac 540tgtggagaag ggcactcgtg ccatagtccc
gtagcactag aacgcatcag aaatgaagcg 600acagacggga cgctgaaaat
ccaggtctcc ttgcaaatcg gaataaagac ggatgacagc 660cacgattgga
ccaagctgcg ttatatggac aaccacatgc cagcagacgc agagagggcg
720gggctatttg taagaacatc agcaccgtgt acgattactg gaacaatggg
acacttcatc 780ctggcccgat gtccaaaagg ggaaactctg acggtgggat
tcactgacag taggaagatt 840agtcactcat gtacgcaccc atttcaccac
gaccctcctg tgataggtcg ggaaaaattc 900cattcccgac cgcagcacgg
taaagagata ccttgcagca cgtacgtgca gagcaccgcc 960gcaactaccg
aggagataga ggtacacatg cccccagaca cccctgatcg cacattaatg
1020tcacaacagt ccggcaacgt aaagatcaca gtcaatggcc agacggtgcg
gtacaagtgt 1080aattgcggtg gctcaaatga aggactaaca actacagaca
aagtgattaa taactgcaag 1140gttgatcaat gtcatgccgc ggtcaccaat
cacaaaaagt ggcagtataa ctcccctctg 1200gtcccgcgta atgctgaact
tggggaccga aaaggaaaaa ttcacatccc gtttccgctg 1260gcaaatgtaa
catgcagggt gcctaaagca aggaacccca ccgtgacgta cgggaaaaac
1320caagtcatca tgctactgta tcctgaccac ccaacactcc tgtcctaccg
gaatatggga 1380gaagaaccaa actatcaaga agagtgggtg atgcataaga
aggaagtcgt gctaaccgtg 1440ccgactgaag ggctcgaggt cacgtggggc
aacaacgagc cgtataagta ttggccgcag 1500ttatctacaa acggtacagc
ccatggccac ccgcatgaga taattctgta ttattatgag 1560ctgtacccca
ctatgactgt agtagttgtg tcagtggcca cgttcatact cctgtcgatg
1620gtgggtatgg cagcggggat gtgcatgtgt gcacgacgca gatgcatcac
accgtatgaa 1680ctgacaccag gagctaccgt ccctttcctg cttagcctaa
tatgctgcat cagaacagct 1740aaagcggcca cataccaaga ggctgcgata
tacctgtgga acgagcagca accttta 1797111092DNAChikungunya virus
11gacaacttca atgtctataa agccacaaga ccatacttag ctcactgtcc cgactgtgga
60gaagggcact cgtgccatag tcccgtagca ctagaacgca tcagaaatga agcgacagac
120gggacgctga aaatccaggt ctccttgcaa atcggaataa agacggatga
cagccacgat 180tggaccaagc tgcgttatat ggacaaccac atgccagcag
acgcagagag ggcggggcta 240tttgtaagaa catcagcacc gtgtacgatt
actggaacaa tgggacactt catcctggcc 300cgatgtccaa aaggggaaac
tctgacggtg ggattcactg acagtaggaa gattagtcac 360tcatgtacgc
acccatttca ccacgaccct cctgtgatag gtcgggaaaa attccattcc
420cgaccgcagc acggtaaaga gctaccttgc agcacgtacg tgcagagcac
cgccgcaact 480accgaggaga tagaggtaca catgccccca gacacccctg
atcgcacatt aatgtcacaa 540cagtccggca acgtaaagat cacagtcaat
ggccagacgg tgcggtacaa gtgtaattgc 600ggtggctcaa atgaaggact
aacaactaca gacaaagtga ttaataactg caaggttgat 660caatgtcatg
ccgcggtcac caatcacaaa aagtggcagt ataactcccc tctggtcccg
720cgtaatgctg aacttgggga ccgaaaagga aaaattcaca tcccgtttcc
gctggcaaat 780gtaacatgca gggtgcctaa agcaaggaac cccaccgtga
cgtacgggaa aaaccaagtc 840atcatgctac tgtatcctga ccacccaaca
ctcctgtcct accggaatat gggagaagaa 900ccaaactatc aagaagagtg
ggtgatgcat aagaaggaag tcgtgctaac cgtgccgact 960gaagggctcg
aggtcacgtg gggcaacaac gagccgtata agtattggcc gcagttatct
1020acaaacggta cagcccatgg ccacccgcat gagataattc tgtattatta
tgagctgtac 1080cccactatga ct 1092121092DNAChikungunya virus
12gacaacttca atgtctataa agccacaaga ccatacttag ctcactgtcc cgactgtgga
60gaagggcact cgtgccatag tcccgtagca ctagaacgca tcagaaatga agcgacagac
120gggacgctga aaatccaggt ctccttgcaa atcggaataa agacggatga
cagccacgat 180tggaccaagc tgcgttatat ggacaaccac atgccagcag
acgcagagag ggcggggcta 240tttgtaagaa catcagcacc gtgtacgatt
actggaacaa tgggacactt catcctggcc 300cgatgtccaa aaggggaaac
tctgacggtg ggattcactg acagtaggaa gattagtcac 360tcatgtacgc
acccatttca ccacgaccct cctgtgatag gtcgggaaaa attccattcc
420cgaccgcagc acggtaaaga gctaccttgc agcacgtacg tgcagagcac
cgccgcaact 480accgaggaga tagaggtaca catgccccca gacacccctg
atcgcacatt aatgtcacaa 540cagtccggca acgtaaagat cacagtcaat
ggccagacgg tgcggtacaa gtgtaattgc 600ggtggctcaa atgaaggact
aacaactaca gacaaagtga ttaataactg caaggttgat 660caatgtcatg
ccgcggtcac caatcacaaa aagtggcagt ataactcccc tctggtcccg
720cgtaatgctg aacttgggga ccgaaaagga aaaattcaca tcccgtttcc
gctggcaaat 780gtaacatgca gggtgcctaa agcaaggaac cccaccgtga
cgtacgggaa aaaccaagtc 840atcatgctac tgtatcctga ccacccaaca
ctcctgtcct accggaatat gggagaagaa 900ccaaactatc aagaagagtg
ggtgatgcat aagaaggaag tcgtgctaac cgtgccgact 960gaagggctcg
aggtcacgtg gggcaacaac gagccgtata agtattggcc gcagttatct
1020acaaacggta cagcccatgg ccacccgcat gagataattc tgtattatta
tgagctgtac 1080cccactatga ct 1092131092DNAChikungunya virus
13gacaacttca atgtctataa agccacaaga ccatacttag ctcactgtcc cgactgtgga
60gaagggcact cgtgccatag tcccgtagca ctagaacgca tcagaaatga agcgacagac
120gggacgctga aaatccaggt ctccttgcaa atcggaataa agacggatga
cagccacgat 180tggaccaagc tgcgttatat ggacaaccac atgccagcag
acgcagagag ggcggggcta 240tttgtaagaa catcagcacc gtgtacgatt
actggaacaa tgggacactt catcctggcc 300cgatgtccaa aaggggaaac
tctgacggtg ggattcactg acagtaggaa gattagtcac 360tcatgtacgc
acccatttca ccacgaccct cctgtgatag gtcgggaaaa attccattcc
420cgaccgcagc acggtaaaga gctaccttgc agcacgtacg tgcagagcac
cgccgcaact 480accgaggaga tagaggtaca catgccccca gacacccctg
atcgcacatt aatgtcacaa 540cagtccggca acgtaaagat cacagtcaat
ggccagacgg tgcggtacaa gtgtaattgc 600ggtggctcaa atgaaggact
aacaactaca gacaaagtga ttaataactg caaggttgat 660caatgtcatg
ccgcggtcac caatcacaaa aagtggcagt ataactcccc tctggtcccg
720cgtaatgctg aacttgggga ccgaaaagga aaaattcaca tcccgtttcc
gctggcaaat 780gtaacatgca gggtgcctaa agcaaggaac cccaccgtga
cgtacgggaa aaaccaagtc 840atcatgctac tgtatcctga ccacccaaca
ctcctgtcct accggaatat gggagaagaa 900ccaaactatc aagaagagtg
ggtgatgcat aagaaggaag tcgtgctaac cgtgccgact 960gaagggctcg
aggtcacgtg gggcaacaac gagccgtata agtattggcc gcagttatct
1020acaaacggta cagcccatgg ccacccgcac gagataattc tgtattatta
tgagctgtac 1080cccactatga ct 1092141092DNAChikungunya virus
14gacaacttca atgtctataa agccacaaga ccatacttag ctcactgtcc cgactgtgga
60gaagggcact cgtgccatag tcccgtagca ctagaacgca tcagaaatga agcgacagac
120gggacgctga aaatccaggt ctccttgcaa atcggaataa agacggatga
cagccacgat 180tggaccaagc tgcgttatat ggacaaccac atgccagcag
acgcagagag ggcggggcta 240tttgtaagaa catcagcacc gtgtacgatt
actggaacaa tgggacactt catcctggcc 300cgatgtccaa aaggggaaac
tctgacggtg ggattcactg acagtaggaa gattagtcac 360tcatgtacgc
acccatttca ccacgaccct cctgtgatag gtcgggaaaa attccattcc
420cgaccgcagc acggtaaaga gataccttgc agcacgtacg tgcagagcac
cgccgcaact 480accgaggaga tagaggtaca catgccccca gacacccctg
atcgcacatt aatgtcacaa 540cagtccggca acgtaaagat cacagtcaat
ggccagacgg tgcggtacaa gtgtaattgc 600ggtggctcaa atgaaggact
aacaactaca gacaaagtga ttaataactg caaggttgat 660caatgtcatg
ccgcggtcac caatcacaaa aagtggcagt ataactcccc tctggtcccg
720cgtaatgctg aacttgggga ccgaaaagga aaaattcaca tcccgtttcc
gctggcaaat 780gtaacatgca gggtgcctaa agcaaggaac cccaccgtga
cgtacgggaa aaaccaagtc 840atcatgctac tgtatcctga ccacccaaca
ctcctgtcct accggaatat gggagaagaa 900ccaaactatc aagaagagtg
ggtgatgcat aagaaggaag tcgtgctaac cgtgccgact 960gaagggctcg
aggtcacgtg gggcaacaac gagccgtata agtattggcc gcagttatct
1020acaaacggta cagcccatgg ccacccgcat gagataattc tgtattatta
tgagctgtac 1080cccactatga ct 109215599PRTChikungunya virus 15Ile
Pro Val His Met Lys Ser Asp Ala Ser Lys Phe Thr His Glu Lys1 5 10
15Pro Glu Gly Tyr Tyr Asn Trp His His Gly Ala Val Gln Tyr Ser Gly
20 25 30Gly Arg Phe Thr Ile Pro Thr Gly Ala Gly Lys Pro Gly Asp Ser
Gly 35 40 45Arg Pro Ile Phe Asp Asn Lys Gly Arg Val Val Ala Ile Val
Leu Gly 50 55 60Gly Ala Asn Glu Gly Ala Arg Thr Ala Leu Ser Val Val
Thr Trp Asn65 70 75 80Lys Asp Ile Val Thr Lys Ile Thr Pro Glu Gly
Ala Glu Glu Trp Ser 85 90 95Leu Ala Ile Pro Val Met Cys Leu Leu Ala
Asn Thr Thr Phe Pro Cys 100 105 110Ser Gln Pro Pro Cys Thr Pro Cys
Cys Tyr Glu Lys Glu Pro Glu Glu 115 120 125Thr Leu Arg Met Leu Glu
Asp Asn Val Met Arg Pro Gly Tyr Tyr Gln 130 135 140Leu Leu Gln Ala
Ser Leu Thr Cys Ser Pro His Arg Gln Arg Arg Ser145 150 155 160Thr
Lys Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala 165 170
175His Cys Pro Asp Cys Gly Glu Gly His Ser Cys His Ser Pro Val Ala
180 185 190Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys
Ile Gln 195 200 205Val Ser Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser
His Asp Trp Thr 210 215 220Lys Leu Arg Tyr Met Asp Asn His Met Pro
Ala Asp Ala Glu Arg Ala225 230 235 240Gly Leu Phe Val Arg Thr Ser
Ala Pro Cys Thr Ile Thr Gly Thr Met 245 250 255Gly His Phe Ile Leu
Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val 260 265 270Gly Phe Thr
Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro Phe 275 280 285His
His Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro 290 295
300Gln His Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr
Ala305 310 315 320Ala Thr Thr Glu Glu Ile Glu Val His Met Pro Pro
Asp Thr Pro Asp 325 330 335Arg Thr Leu Met Ser Gln Gln Ser Gly Asn
Val Lys Ile Thr Val Asn 340 345 350Gly Gln Thr Val Arg Tyr Lys Cys
Asn Cys Gly Gly Ser Asn Glu Gly 355 360 365Leu Thr Thr Thr Asp Lys
Val Ile Asn Asn Cys Lys Val Asp Gln Cys 370 375 380His Ala Ala Val
Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu385 390 395 400Val
Pro Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile 405 410
415Pro Phe Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg Asn
420 425 430Pro Thr Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu Leu
Tyr Pro 435 440 445Asp His Pro Thr Leu Leu Ser Tyr Arg Asn Met Gly
Glu Glu Pro Asn 450 455 460Tyr Gln Glu Glu Trp Val Met His Lys Lys
Glu Val Val Leu Thr Val465 470 475 480Pro Thr Glu Gly Leu Glu Val
Thr Trp Gly Asn Asn Glu Pro Tyr Lys 485 490 495Tyr Trp Pro Gln Leu
Ser Thr Asn Gly Thr Ala His Gly His Pro His 500 505 510Glu Ile Ile
Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr Val Val 515 520 525Val
Val Ser Val Ala Thr Phe Ile Leu Leu Ser Met Val Gly Met Ala 530 535
540Ala Gly Met Cys Met Arg Ala Arg Arg Arg Cys Ile Thr Pro Tyr
Glu545 550 555 560Leu Thr Pro Gly Ala Thr Val Pro Phe Leu Leu Ser
Leu Ile Cys Cys 565 570 575Ile Arg Thr Ala Lys Ala Ala Thr Tyr Gln
Glu Ala Ala Ile Tyr Leu 580 585 590Trp Asn Glu Gln Gln Pro Leu
59516599PRTChikungunya virus 16Ile Pro Val His Met Lys Ser Asp Ala
Ser Lys Phe Thr His Glu Lys1 5 10 15Pro Glu Gly Tyr Tyr Asn Trp His
His Gly Ala Val Gln Tyr Ser Gly 20 25 30Gly Arg Phe Thr Ile Pro Thr
Gly Ala Gly Lys Pro Gly Asp Ser Gly 35 40 45Arg Pro Ile Phe Asp Asn
Lys Gly Arg Val Val Ala Ile Val Leu Gly 50 55 60Gly Ala Asn Glu Gly
Ala Arg Thr Ala Leu Ser Val Val Thr Trp Asn65 70 75 80Lys Asp Ile
Val Thr Lys Ile Thr Pro Glu Gly Ala Glu Glu Trp Ser 85 90 95Leu Ala
Ile Pro Val Met Cys Leu Leu Ala Asn Thr Thr Phe Pro Cys 100 105
110Ser Gln Pro Pro Cys Thr Pro Cys Cys Tyr Glu Lys Glu Pro Glu Glu
115 120 125Thr Leu Arg Met Leu Glu Asp Asn Val Met Arg Pro Gly Tyr
Tyr Gln 130 135 140Leu Leu Gln Ala Ser Leu Thr Cys Ser Pro His Arg
Gln Arg Arg Ser145 150 155 160Thr Lys Asp Asn Phe Asn Val Tyr Lys
Ala Thr Arg Pro Tyr Leu Ala 165 170 175His Cys Pro Asp Cys Gly Glu
Gly His Ser Cys His Ser Pro Val Ala 180 185 190Leu Glu Arg Ile Arg
Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile Gln 195 200 205Val Ser Leu
Gln Ile Gly Ile Lys Thr Asp Asp Ser His Asp Trp Thr 210 215 220Lys
Leu Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala Glu Arg Ala225 230
235 240Gly Leu Phe Val Arg Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr
Met 245 250 255Gly His Phe Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr
Leu Thr Val 260 265 270Gly Phe Thr Asp Ser Arg Lys Ile Ser His Ser
Cys Thr His Pro Phe 275 280 285His His Asp Pro Pro Val Ile Gly Arg
Glu Lys Phe His Ser Arg Pro 290 295 300Gln His Gly Lys Glu Leu Pro
Cys Ser Thr Tyr Val Gln Ser Thr Ala305 310 315 320Ala Thr Thr Glu
Glu Ile Glu Val His Met Pro Pro Asp Thr Pro Asp 325 330 335Arg Thr
Leu Met Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val Asn 340 345
350Gly Gln Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu Gly
355 360 365Leu Thr Thr Thr Asp Lys Val Ile Asn Asn Cys Lys Val Asp
Gln Cys 370 375 380His Ala Ala Val Thr Asn His Lys Lys Trp Gln Tyr
Asn Ser Pro Leu385 390 395 400Val Pro Arg Asn Ala Glu Leu Gly Asp
Arg Lys Gly Lys Ile His Ile 405 410 415Pro Phe Pro Leu Ala Asn Val
Thr Cys Arg Val Pro Lys Ala Arg Asn 420 425 430Pro Thr Val Thr Tyr
Gly Lys Asn Gln Val Ile Met Leu Leu Tyr Pro 435 440 445Asp His Pro
Thr Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro Asn 450 455 460Tyr
Gln Glu Glu Trp Val Met His Lys Lys Glu Val Val Leu Thr Val465 470
475 480Pro Thr Glu Gly Leu Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr
Lys 485 490 495Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr Ala His Gly
His Pro His 500 505 510Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro
Thr Met Thr Val Val 515 520 525Val Val Ser Val Ala Thr Phe Ile Leu
Leu Ser Met Val Gly Met Ala 530 535 540Ala Gly Met Cys Met Cys Ala
Arg Arg Arg Cys Ile Thr Pro Tyr Glu545 550 555 560Leu Thr Pro Gly
Ala Thr Val Pro Phe Leu Leu Ser Leu Ile Cys Cys 565 570 575Ile Arg
Thr Ala Lys Ala Ala Thr Tyr Gln Glu Ala Ala Ile Tyr Leu 580 585
590Trp Asn Glu Gln Gln Pro Leu 59517599PRTChikungunya virus 17Ile
Pro Val His Met Lys Ser Asp Ala Ser Lys Phe Thr His Glu Lys1 5 10
15Pro Glu Gly Tyr Tyr Asn Trp His His Gly Ala Val Gln Tyr Ser Gly
20 25 30Gly Arg Phe Thr Ile Pro Thr Gly Ala Gly Lys Pro Gly Asp Ser
Gly 35 40 45Arg Pro Ile Phe Asp Asn Lys Gly Arg Val Val Ala Ile Val
Leu Gly 50 55 60Gly Ala Asn Glu Gly Ala Arg Thr Ala Leu Ser Val Val
Thr Trp Asn65 70 75 80Lys Asp Ile Val Thr Lys Ile Thr Pro Glu Gly
Ala Glu Glu Trp Ser 85 90 95Leu Ala Ile Pro Val Met Cys Leu Leu Ala
Asn Thr Thr Phe Pro Cys 100 105 110Ser Gln Pro Pro Cys Thr Pro Cys
Cys Tyr Glu Lys Glu Pro Glu Glu 115 120 125Thr Leu Arg Met Leu Glu
Asp Asn Val Met Arg Pro Gly Tyr Tyr Gln 130 135 140Leu Leu Gln Ala
Ser Leu Thr Cys Ser Pro His Arg Gln Arg Arg Ser145 150 155 160Thr
Lys Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala 165 170
175His Cys Pro Asp Cys Gly Glu Gly His Ser Cys His Ser Pro Val Ala
180 185 190Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys
Ile Gln 195 200 205Val Ser Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser
His Asp Trp Thr 210 215
220Lys Leu Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala Glu Arg
Ala225 230 235 240Gly Leu Phe Val Arg Thr Ser Ala Pro Cys Thr Ile
Thr Gly Thr Met 245 250 255Gly His Phe Ile Leu Ala Arg Cys Pro Lys
Gly Glu Thr Leu Thr Val 260 265 270Gly Phe Thr Asp Ser Arg Lys Ile
Ser His Ser Cys Thr His Pro Phe 275 280 285His His Asp Pro Pro Val
Ile Gly Arg Glu Lys Phe His Ser Arg Pro 290 295 300Gln His Gly Lys
Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr Ala305 310 315 320Ala
Thr Thr Glu Glu Ile Glu Val His Met Pro Pro Asp Thr Pro Asp 325 330
335Arg Thr Leu Met Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val Asn
340 345 350Gly Gln Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn
Glu Gly 355 360 365Leu Thr Thr Thr Asp Lys Val Ile Asn Asn Cys Lys
Val Asp Gln Cys 370 375 380His Ala Ala Val Thr Asn His Lys Lys Trp
Gln Tyr Asn Ser Pro Leu385 390 395 400Val Pro Arg Asn Ala Glu Leu
Gly Asp Arg Lys Gly Lys Ile His Ile 405 410 415Pro Phe Pro Leu Ala
Asn Val Thr Cys Arg Val Pro Lys Ala Arg Asn 420 425 430Pro Thr Val
Thr Tyr Gly Lys Asn Gln Val Ile Met Leu Leu Tyr Pro 435 440 445Asp
His Pro Thr Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro Asn 450 455
460Tyr Gln Glu Glu Trp Val Met His Lys Lys Glu Val Val Leu Thr
Val465 470 475 480Pro Thr Glu Gly Leu Glu Val Thr Trp Gly Asn Asn
Glu Pro Tyr Lys 485 490 495Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr
Ala His Gly His Pro His 500 505 510Glu Ile Ile Leu Tyr Tyr Tyr Glu
Leu Tyr Pro Thr Met Thr Val Val 515 520 525Val Val Ser Val Ala Thr
Phe Ile Leu Leu Ser Met Val Gly Met Ala 530 535 540Ala Gly Met Cys
Met Cys Ala Arg Arg Arg Cys Ile Thr Pro Tyr Glu545 550 555 560Leu
Thr Pro Gly Ala Thr Val Pro Phe Leu Leu Ser Leu Ile Cys Cys 565 570
575Ile Arg Thr Ala Lys Ala Ala Thr Tyr Gln Glu Ala Ala Ile Tyr Leu
580 585 590Trp Asn Glu Gln Gln Pro Leu 59518599PRTChikungunya virus
18Ile Pro Val His Met Lys Ser Asp Ala Ser Lys Phe Thr His Glu Lys1
5 10 15Pro Glu Gly Tyr Tyr Asn Trp His His Gly Ala Val Gln Tyr Ser
Gly 20 25 30Gly Arg Phe Thr Ile Pro Thr Gly Ala Gly Lys Pro Gly Asp
Ser Gly 35 40 45Arg Pro Ile Phe Asp Asn Lys Gly Arg Val Val Ala Ile
Val Leu Gly 50 55 60Gly Ala Asn Glu Gly Ala Arg Thr Ala Leu Ser Val
Val Thr Trp Asn65 70 75 80Lys Asp Ile Val Thr Lys Ile Thr Pro Glu
Gly Ala Glu Glu Trp Ser 85 90 95Leu Ala Ile Pro Val Met Cys Leu Leu
Ala Asn Thr Thr Phe Pro Cys 100 105 110Ser Gln Pro Pro Cys Thr Pro
Cys Cys Tyr Glu Lys Glu Pro Glu Glu 115 120 125Thr Leu Arg Met Leu
Glu Asp Asn Val Met Arg Pro Gly Tyr Tyr Gln 130 135 140Leu Leu Gln
Ala Ser Leu Thr Cys Ser Pro His Arg Gln Arg Arg Ser145 150 155
160Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala
165 170 175His Cys Pro Asp Cys Gly Glu Gly His Ser Cys His Ser Pro
Val Ala 180 185 190Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr
Leu Lys Ile Gln 195 200 205Val Ser Leu Gln Ile Gly Ile Lys Thr Asp
Asp Ser His Asp Trp Thr 210 215 220Lys Leu Arg Tyr Met Asp Asn His
Met Pro Ala Asp Ala Glu Arg Ala225 230 235 240Gly Leu Phe Val Arg
Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr Met 245 250 255Gly His Phe
Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val 260 265 270Gly
Phe Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro Phe 275 280
285His His Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro
290 295 300Gln His Gly Lys Glu Ile Pro Cys Ser Thr Tyr Val Gln Ser
Thr Ala305 310 315 320Ala Thr Thr Glu Glu Ile Glu Val His Met Pro
Pro Asp Thr Pro Asp 325 330 335Arg Thr Leu Met Ser Gln Gln Ser Gly
Asn Val Lys Ile Thr Val Asn 340 345 350Gly Gln Thr Val Arg Tyr Lys
Cys Asn Cys Gly Gly Ser Asn Glu Gly 355 360 365Leu Thr Thr Thr Asp
Lys Val Ile Asn Asn Cys Lys Val Asp Gln Cys 370 375 380His Ala Ala
Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu385 390 395
400Val Pro Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile
405 410 415Pro Phe Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala
Arg Asn 420 425 430Pro Thr Val Thr Tyr Gly Lys Asn Gln Val Ile Met
Leu Leu Tyr Pro 435 440 445Asp His Pro Thr Leu Leu Ser Tyr Arg Asn
Met Gly Glu Glu Pro Asn 450 455 460Tyr Gln Glu Glu Trp Val Met His
Lys Lys Glu Val Val Leu Thr Val465 470 475 480Pro Thr Glu Gly Leu
Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys 485 490 495Tyr Trp Pro
Gln Leu Ser Thr Asn Gly Thr Ala His Gly His Pro His 500 505 510Glu
Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr Val Val 515 520
525Val Val Ser Val Ala Thr Phe Ile Leu Leu Ser Met Val Gly Met Ala
530 535 540Ala Gly Met Cys Met Cys Ala Arg Arg Arg Cys Ile Thr Pro
Tyr Glu545 550 555 560Leu Thr Pro Gly Ala Thr Val Pro Phe Leu Leu
Ser Leu Ile Cys Cys 565 570 575Ile Arg Thr Ala Lys Ala Ala Thr Tyr
Gln Glu Ala Ala Ile Tyr Leu 580 585 590Trp Asn Glu Gln Gln Pro Leu
59519364PRTChikungunya virus 19Asp Asn Phe Asn Val Tyr Lys Ala Thr
Arg Pro Tyr Leu Ala His Cys1 5 10 15Pro Asp Cys Gly Glu Gly His Ser
Cys His Ser Pro Val Ala Leu Glu 20 25 30Arg Ile Arg Asn Glu Ala Thr
Asp Gly Thr Leu Lys Ile Gln Val Ser 35 40 45Leu Gln Ile Gly Ile Lys
Thr Asp Asp Ser His Asp Trp Thr Lys Leu 50 55 60Arg Tyr Met Asp Asn
His Met Pro Ala Asp Ala Glu Arg Ala Gly Leu65 70 75 80Phe Val Arg
Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr Met Gly His 85 90 95Phe Ile
Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val Gly Phe 100 105
110Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro Phe His His
115 120 125Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro
Gln His 130 135 140Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser
Thr Ala Ala Thr145 150 155 160Thr Glu Glu Ile Glu Val His Met Pro
Pro Asp Thr Pro Asp Arg Thr 165 170 175Leu Met Ser Gln Gln Ser Gly
Asn Val Lys Ile Thr Val Asn Gly Gln 180 185 190Thr Val Arg Tyr Lys
Cys Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr 195 200 205Thr Thr Asp
Lys Val Ile Asn Asn Cys Lys Val Asp Gln Cys His Ala 210 215 220Ala
Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro225 230
235 240Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile Pro
Phe 245 250 255Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg
Asn Pro Thr 260 265 270Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu
Leu Tyr Pro Asp His 275 280 285Pro Thr Leu Leu Ser Tyr Arg Asn Met
Gly Glu Glu Pro Asn Tyr Gln 290 295 300Glu Glu Trp Val Met His Lys
Lys Glu Val Val Leu Thr Val Pro Thr305 310 315 320Glu Gly Leu Glu
Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp 325 330 335Pro Gln
Leu Ser Thr Asn Gly Thr Ala His Gly His Pro His Glu Ile 340 345
350Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr 355
36020364PRTChikungunya virus 20Asp Asn Phe Asn Val Tyr Lys Ala Thr
Arg Pro Tyr Leu Ala His Cys1 5 10 15Pro Asp Cys Gly Glu Gly His Ser
Cys His Ser Pro Val Ala Leu Glu 20 25 30Arg Ile Arg Asn Glu Ala Thr
Asp Gly Thr Leu Lys Ile Gln Val Ser 35 40 45Leu Gln Ile Gly Ile Lys
Thr Asp Asp Ser His Asp Trp Thr Lys Leu 50 55 60Arg Tyr Met Asp Asn
His Met Pro Ala Asp Ala Glu Arg Ala Gly Leu65 70 75 80Phe Val Arg
Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr Met Gly His 85 90 95Phe Ile
Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val Gly Phe 100 105
110Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro Phe His His
115 120 125Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro
Gln His 130 135 140Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser
Thr Ala Ala Thr145 150 155 160Thr Glu Glu Ile Glu Val His Met Pro
Pro Asp Thr Pro Asp Arg Thr 165 170 175Leu Met Ser Gln Gln Ser Gly
Asn Val Lys Ile Thr Val Asn Gly Gln 180 185 190Thr Val Arg Tyr Lys
Cys Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr 195 200 205Thr Thr Asp
Lys Val Ile Asn Asn Cys Lys Val Asp Gln Cys His Ala 210 215 220Ala
Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro225 230
235 240Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile Pro
Phe 245 250 255Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg
Asn Pro Thr 260 265 270Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu
Leu Tyr Pro Asp His 275 280 285Pro Thr Leu Leu Ser Tyr Arg Asn Met
Gly Glu Glu Pro Asn Tyr Gln 290 295 300Glu Glu Trp Val Met His Lys
Lys Glu Val Val Leu Thr Val Pro Thr305 310 315 320Glu Gly Leu Glu
Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp 325 330 335Pro Gln
Leu Ser Thr Asn Gly Thr Ala His Gly His Pro His Glu Ile 340 345
350Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr 355
36021364PRTChikungunya virus 21Asp Asn Phe Asn Val Tyr Lys Ala Thr
Arg Pro Tyr Leu Ala His Cys1 5 10 15Pro Asp Cys Gly Glu Gly His Ser
Cys His Ser Pro Val Ala Leu Glu 20 25 30Arg Ile Arg Asn Glu Ala Thr
Asp Gly Thr Leu Lys Ile Gln Val Ser 35 40 45Leu Gln Ile Gly Ile Lys
Thr Asp Asp Ser His Asp Trp Thr Lys Leu 50 55 60Arg Tyr Met Asp Asn
His Met Pro Ala Asp Ala Glu Arg Ala Gly Leu65 70 75 80Phe Val Arg
Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr Met Gly His 85 90 95Phe Ile
Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val Gly Phe 100 105
110Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro Phe His His
115 120 125Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro
Gln His 130 135 140Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser
Thr Ala Ala Thr145 150 155 160Thr Glu Glu Ile Glu Val His Met Pro
Pro Asp Thr Pro Asp Arg Thr 165 170 175Leu Met Ser Gln Gln Ser Gly
Asn Val Lys Ile Thr Val Asn Gly Gln 180 185 190Thr Val Arg Tyr Lys
Cys Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr 195 200 205Thr Thr Asp
Lys Val Ile Asn Asn Cys Lys Val Asp Gln Cys His Ala 210 215 220Ala
Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro225 230
235 240Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile Pro
Phe 245 250 255Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg
Asn Pro Thr 260 265 270Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu
Leu Tyr Pro Asp His 275 280 285Pro Thr Leu Leu Ser Tyr Arg Asn Met
Gly Glu Glu Pro Asn Tyr Gln 290 295 300Glu Glu Trp Val Met His Lys
Lys Glu Val Val Leu Thr Val Pro Thr305 310 315 320Glu Gly Leu Glu
Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp 325 330 335Pro Gln
Leu Ser Thr Asn Gly Thr Ala His Gly His Pro His Glu Ile 340 345
350Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr 355
36022364PRTChikungunya virus 22Asp Asn Phe Asn Val Tyr Lys Ala Thr
Arg Pro Tyr Leu Ala His Cys1 5 10 15Pro Asp Cys Gly Glu Gly His Ser
Cys His Ser Pro Val Ala Leu Glu 20 25 30Arg Ile Arg Asn Glu Ala Thr
Asp Gly Thr Leu Lys Ile Gln Val Ser 35 40 45Leu Gln Ile Gly Ile Lys
Thr Asp Asp Ser His Asp Trp Thr Lys Leu 50 55 60Arg Tyr Met Asp Asn
His Met Pro Ala Asp Ala Glu Arg Ala Gly Leu65 70 75 80Phe Val Arg
Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr Met Gly His 85 90 95Phe Ile
Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val Gly Phe 100 105
110Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro Phe His His
115 120 125Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro
Gln His 130 135 140Gly Lys Glu Ile Pro Cys Ser Thr Tyr Val Gln Ser
Thr Ala Ala Thr145 150 155 160Thr Glu Glu Ile Glu Val His Met Pro
Pro Asp Thr Pro Asp Arg Thr 165 170 175Leu Met Ser Gln Gln Ser Gly
Asn Val Lys Ile Thr Val Asn Gly Gln 180 185 190Thr Val Arg Tyr Lys
Cys Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr 195 200 205Thr Thr Asp
Lys Val Ile Asn Asn Cys Lys Val Asp Gln Cys His Ala 210 215 220Ala
Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro225 230
235 240Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile Pro
Phe 245 250 255Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg
Asn Pro Thr 260 265 270Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu
Leu Tyr Pro Asp His 275 280 285Pro Thr Leu Leu Ser Tyr Arg Asn Met
Gly Glu Glu Pro Asn Tyr Gln 290 295 300Glu Glu Trp Val Met His Lys
Lys Glu Val Val Leu Thr Val Pro Thr305 310 315 320Glu Gly Leu Glu
Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp 325 330 335Pro Gln
Leu Ser Thr Asn Gly Thr Ala His Gly His Pro His Glu Ile 340 345
350Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr 355
360231248PRTChikungunya virus 23Met Glu Phe Ile Pro Thr Gln Thr Phe
Tyr Asn Arg Arg Tyr Gln Pro1 5 10 15Arg Pro Trp Thr Pro Arg Pro Thr
Ile Gln Val Ile Arg Pro Arg Pro 20 25
30Arg Pro Gln Arg Gln Ala Gly Gln Leu Ala Gln Leu Ile Ser Ala Val
35 40 45Asn Lys Leu Thr Met Arg Ala Val Pro Gln Gln Lys Pro Arg Arg
Asn 50 55 60Arg Lys Asn Lys Lys Gln Lys Gln Lys Gln Gln Ala Pro Gln
Asn Asn65 70 75 80Thr Asn Gln Lys Lys Gln Pro Pro Lys Lys Lys Pro
Ala Gln Lys Lys 85 90 95Lys Lys Pro Gly Arg Arg Glu Arg Met Cys Met
Lys Ile Glu Asn Asp 100 105 110Cys Ile Phe Glu Val Lys His Glu Gly
Lys Val Thr Gly Tyr Ala Cys 115 120 125Leu Val Gly Asp Lys Val Met
Lys Pro Ala His Val Lys Gly Thr Ile 130 135 140Asp Asn Ala Asp Leu
Ala Lys Leu Ala Phe Lys Arg Ser Ser Lys Tyr145 150 155 160Asp Leu
Glu Cys Ala Gln Ile Pro Val His Met Lys Ser Asp Ala Ser 165 170
175Lys Phe Thr His Glu Lys Pro Glu Gly Tyr Tyr Asn Trp His His Gly
180 185 190Ala Val Gln Tyr Ser Gly Gly Arg Phe Thr Ile Pro Thr Gly
Ala Gly 195 200 205Lys Pro Gly Asp Ser Gly Arg Pro Ile Phe Asp Asn
Lys Gly Arg Val 210 215 220Val Ala Ile Val Leu Gly Gly Ala Asn Glu
Gly Ala Arg Thr Ala Leu225 230 235 240Ser Val Val Thr Trp Asn Lys
Asp Ile Val Thr Lys Ile Thr Pro Glu 245 250 255Gly Ala Glu Glu Trp
Ser Leu Ala Ile Pro Val Met Cys Leu Leu Ala 260 265 270Asn Thr Thr
Phe Pro Cys Ser Gln Pro Pro Cys Ile Pro Cys Cys Tyr 275 280 285Glu
Lys Glu Pro Glu Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met 290 295
300Arg Pro Gly Tyr Tyr Gln Leu Leu Gln Ala Ser Leu Thr Cys Ser
Pro305 310 315 320His Arg Gln Arg Arg Ser Thr Lys Asp Asn Phe Asn
Val Tyr Lys Ala 325 330 335Thr Arg Pro Tyr Leu Ala His Cys Pro Asp
Cys Gly Glu Gly His Ser 340 345 350Cys His Ser Pro Val Ala Leu Glu
Arg Ile Arg Asn Glu Ala Thr Asp 355 360 365Gly Thr Leu Lys Ile Gln
Val Ser Leu Gln Ile Gly Ile Gly Thr Asp 370 375 380Asp Ser His Asp
Trp Thr Lys Leu Arg Tyr Met Asp Asn His Ile Pro385 390 395 400Ala
Asp Ala Gly Arg Ala Gly Leu Phe Val Arg Thr Ser Ala Pro Cys 405 410
415Thr Ile Thr Gly Thr Met Gly His Phe Ile Leu Ala Arg Cys Pro Lys
420 425 430Gly Glu Thr Leu Thr Val Gly Phe Thr Asp Ser Arg Lys Ile
Ser His 435 440 445Ser Cys Thr His Pro Phe His His Asp Pro Pro Val
Ile Gly Arg Glu 450 455 460Lys Phe His Ser Arg Pro Gln His Gly Lys
Glu Leu Pro Cys Ser Thr465 470 475 480Tyr Val Gln Ser Asn Ala Ala
Thr Ala Glu Glu Ile Glu Val His Met 485 490 495Pro Pro Asp Thr Pro
Asp Arg Thr Leu Leu Ser Gln Gln Ser Gly Asn 500 505 510Val Lys Ile
Thr Val Asn Gly Arg Thr Val Arg Tyr Lys Cys Asn Cys 515 520 525Gly
Gly Ser Asn Glu Gly Leu Ile Thr Thr Asp Lys Val Ile Asn Asn 530 535
540Cys Lys Val Asp Gln Cys His Ala Ala Val Thr Asn His Lys Lys
Trp545 550 555 560Gln Tyr Asn Ser Pro Leu Val Pro Arg Asn Ala Glu
Leu Gly Asp Arg 565 570 575Lys Gly Lys Ile His Ile Pro Phe Pro Leu
Ala Asn Val Thr Cys Met 580 585 590Val Pro Lys Ala Arg Asn Pro Thr
Val Thr Tyr Gly Lys Asn Gln Val 595 600 605Ile Met Leu Leu Tyr Pro
Asp His Pro Thr Leu Leu Ser Tyr Arg Ser 610 615 620Met Gly Glu Glu
Pro Asn Tyr Gln Glu Glu Trp Val Thr His Lys Lys625 630 635 640Glu
Val Val Leu Thr Val Pro Thr Glu Gly Leu Glu Val Thr Trp Gly 645 650
655Asn Asn Glu Pro Tyr Lys Tyr Trp Pro Gln Leu Ser Ala Asn Gly Thr
660 665 670Ala His Gly His Pro His Glu Ile Ile Leu Tyr Tyr Tyr Glu
Leu Tyr 675 680 685Pro Thr Met Thr Val Val Val Val Ser Val Ala Ser
Phe Ile Leu Leu 690 695 700Ser Met Val Gly Met Ala Val Gly Met Cys
Met Cys Ala Arg Arg Arg705 710 715 720Cys Ile Thr Pro Tyr Glu Leu
Thr Pro Gly Ala Thr Val Pro Phe Leu 725 730 735Leu Ser Leu Ile Cys
Cys Ile Arg Thr Ala Lys Ala Ala Thr Tyr Gln 740 745 750Glu Ala Ala
Val Tyr Leu Trp Asn Glu Gln Gln Pro Leu Phe Trp Leu 755 760 765Gln
Ala Leu Ile Pro Leu Ala Ala Leu Ile Val Leu Cys Asn Cys Leu 770 775
780Arg Leu Leu Pro Cys Cys Cys Lys Thr Leu Ala Phe Leu Ala Val
Met785 790 795 800Ser Ile Gly Ala His Thr Val Ser Ala Tyr Glu His
Val Thr Val Ile 805 810 815Pro Asn Thr Val Gly Val Pro Tyr Lys Thr
Leu Val Asn Arg Pro Gly 820 825 830Tyr Ser Pro Met Val Leu Glu Met
Glu Leu Leu Ser Val Thr Leu Glu 835 840 845Pro Thr Leu Ser Leu Asp
Tyr Ile Thr Cys Glu Tyr Lys Thr Val Ile 850 855 860Pro Ser Pro Tyr
Val Lys Cys Cys Gly Thr Ala Glu Cys Lys Asp Lys865 870 875 880Asn
Leu Pro Asp Tyr Ser Cys Lys Val Phe Thr Gly Val Tyr Pro Phe 885 890
895Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Ala Glu Asn Thr Gln Leu
900 905 910Ser Glu Ala His Val Glu Lys Ser Glu Ser Cys Lys Thr Glu
Phe Ala 915 920 925Ser Ala Tyr Arg Ala His Thr Ala Ser Ala Ser Ala
Lys Leu Arg Val 930 935 940Leu Tyr Gln Gly Asn Asn Ile Thr Val Thr
Ala Tyr Ala Asn Gly Asp945 950 955 960His Ala Val Thr Val Lys Asp
Ala Lys Phe Ile Val Gly Pro Met Ser 965 970 975Ser Ala Trp Thr Pro
Phe Asp Asn Lys Ile Val Val Tyr Lys Gly Asp 980 985 990Val Tyr Asn
Met Asp Tyr Pro Pro Phe Gly Ala Gly Arg Pro Gly Gln 995 1000
1005Phe Gly Asp Ile Gln Ser Arg Thr Pro Glu Ser Lys Asp Val Tyr
1010 1015 1020Ala Asn Thr Gln Leu Val Leu Gln Arg Pro Ala Ala Gly
Thr Val 1025 1030 1035His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe
Lys Tyr Trp Leu 1040 1045 1050Lys Glu Arg Gly Ala Ser Leu Gln His
Thr Ala Pro Phe Gly Cys 1055 1060 1065Gln Ile Ala Thr Asn Pro Val
Arg Ala Met Asn Cys Ala Val Gly 1070 1075 1080Asn Met Pro Ile Ser
Ile Asp Ile Pro Asp Ala Ala Phe Thr Arg 1085 1090 1095Val Val Asp
Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Pro 1100 1105 1110Ala
Cys Thr His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys 1115 1120
1125Tyr Ala Val Ser Lys Lys Gly Lys Cys Ala Val His Ser Met Thr
1130 1135 1140Asn Ala Val Thr Ile Arg Glu Ala Glu Ile Glu Val Glu
Gly Asn 1145 1150 1155Ser Gln Leu Gln Ile Ser Phe Ser Thr Ala Leu
Ala Ser Ala Glu 1160 1165 1170Phe Arg Val Gln Val Cys Ser Thr Gln
Val His Cys Ala Ala Glu 1175 1180 1185Cys His Pro Pro Lys Asp His
Ile Val Asn Tyr Pro Ala Ser His 1190 1195 1200Thr Thr Leu Gly Val
Gln Asp Ile Ser Ala Thr Ala Met Ser Trp 1205 1210 1215Val Gln Lys
Ile Thr Gly Gly Val Gly Leu Val Val Ala Val Ala 1220 1225 1230Ala
Leu Ile Leu Ile Val Val Leu Cys Val Ser Phe Ser Arg His 1235 1240
1245241248PRTChikungunya virus 24Met Glu Phe Ile Pro Thr Gln Thr
Phe Tyr Asn Arg Arg Tyr Gln Pro1 5 10 15Arg Pro Trp Thr Pro Arg Pro
Thr Ile Gln Val Ile Arg Pro Arg Pro 20 25 30Arg Pro Gln Arg Gln Ala
Gly Gln Leu Ala Gln Leu Ile Ser Ala Val 35 40 45Asn Lys Leu Thr Met
Arg Ala Val Pro Gln Gln Lys Pro Arg Arg Asn 50 55 60Arg Lys Asn Lys
Lys Gln Lys Gln Lys Gln Gln Ala Pro Gln Asn Asn65 70 75 80Thr Asn
Gln Lys Lys Gln Pro Pro Lys Lys Lys Pro Ala Gln Lys Lys 85 90 95Lys
Lys Pro Gly Arg Arg Glu Arg Met Cys Met Lys Ile Glu Asn Asp 100 105
110Cys Ile Phe Glu Val Lys His Glu Gly Lys Val Thr Gly Tyr Ala Cys
115 120 125Leu Val Gly Asp Lys Val Met Lys Pro Ala His Val Lys Gly
Thr Ile 130 135 140Asp Asn Ala Asp Leu Ala Lys Leu Ala Phe Lys Arg
Ser Ser Lys Tyr145 150 155 160Asp Leu Glu Cys Ala Gln Ile Pro Val
His Met Lys Ser Asp Ala Ser 165 170 175Lys Phe Thr His Glu Lys Pro
Glu Gly Tyr Tyr Asn Trp His His Gly 180 185 190Ala Val Gln Tyr Ser
Gly Gly Arg Phe Thr Ile Pro Thr Gly Ala Gly 195 200 205Lys Pro Gly
Asp Ser Gly Arg Pro Ile Phe Asp Asn Lys Gly Arg Val 210 215 220Val
Ala Ile Val Leu Gly Gly Ala Asn Glu Gly Ala Arg Thr Ala Leu225 230
235 240Ser Val Val Thr Trp Asn Lys Asp Ile Val Thr Lys Ile Thr Pro
Glu 245 250 255Gly Ala Glu Glu Trp Ser Leu Ala Ile Pro Val Met Cys
Leu Leu Ala 260 265 270Asn Thr Thr Phe Pro Cys Ser Gln Pro Pro Cys
Thr Pro Cys Cys Tyr 275 280 285Glu Lys Glu Pro Glu Glu Thr Leu Arg
Met Leu Glu Asp Asn Val Met 290 295 300Arg Pro Gly Tyr Tyr Gln Leu
Leu Gln Ala Ser Leu Thr Cys Ser Pro305 310 315 320His Arg Gln Arg
Arg Ser Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala 325 330 335Thr Arg
Pro Tyr Leu Ala His Cys Pro Asp Cys Gly Glu Gly His Ser 340 345
350Cys His Ser Pro Val Ala Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp
355 360 365Gly Thr Leu Lys Ile Gln Val Ser Leu Gln Ile Gly Ile Lys
Thr Asp 370 375 380Asp Ser His Asp Trp Thr Lys Leu Arg Tyr Met Asp
Asn His Met Pro385 390 395 400Ala Asp Ala Glu Arg Ala Gly Leu Phe
Val Arg Thr Ser Ala Pro Cys 405 410 415Thr Ile Thr Gly Thr Met Gly
His Phe Ile Leu Ala Arg Cys Pro Lys 420 425 430Gly Glu Thr Leu Thr
Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His 435 440 445Ser Cys Thr
His Pro Phe His His Asp Pro Pro Val Ile Gly Arg Glu 450 455 460Lys
Phe His Ser Arg Pro Gln His Gly Lys Glu Leu Pro Cys Ser Thr465 470
475 480Tyr Val Gln Ser Thr Ala Ala Thr Thr Glu Glu Ile Glu Val His
Met 485 490 495Pro Pro Asp Thr Pro Asp Arg Thr Leu Met Ser Gln Gln
Ser Gly Asn 500 505 510Val Lys Ile Thr Val Asn Gly Gln Thr Val Arg
Tyr Lys Cys Asn Cys 515 520 525Gly Gly Ser Asn Glu Gly Leu Thr Thr
Thr Asp Lys Val Ile Asn Asn 530 535 540Cys Lys Val Asp Gln Cys His
Ala Ala Val Thr Asn His Lys Lys Trp545 550 555 560Gln Tyr Asn Ser
Pro Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg 565 570 575Lys Gly
Lys Ile His Ile Pro Phe Pro Leu Ala Asn Val Thr Cys Arg 580 585
590Val Pro Lys Ala Arg Asn Pro Thr Val Thr Tyr Gly Lys Asn Gln Val
595 600 605Ile Met Leu Leu Tyr Pro Asp His Pro Thr Leu Leu Ser Tyr
Arg Asn 610 615 620Met Gly Glu Glu Pro Asn Tyr Gln Glu Glu Trp Val
Met His Lys Lys625 630 635 640Glu Val Val Leu Thr Val Pro Thr Glu
Gly Leu Glu Val Thr Trp Gly 645 650 655Asn Asn Glu Pro Tyr Lys Tyr
Trp Pro Gln Leu Ser Thr Asn Gly Thr 660 665 670Ala His Gly His Pro
His Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr 675 680 685Pro Thr Met
Thr Val Val Val Val Ser Val Ala Thr Phe Ile Leu Leu 690 695 700Ser
Met Val Gly Met Ala Ala Gly Met Cys Met Cys Ala Arg Arg Arg705 710
715 720Cys Ile Thr Pro Tyr Glu Leu Thr Pro Gly Ala Thr Val Pro Phe
Leu 725 730 735Leu Ser Leu Ile Cys Cys Ile Arg Thr Ala Lys Ala Ala
Thr Tyr Gln 740 745 750Glu Ala Ala Ile Tyr Leu Trp Asn Glu Gln Gln
Pro Leu Phe Trp Leu 755 760 765Gln Ala Leu Ile Pro Leu Ala Ala Leu
Ile Val Leu Cys Asn Cys Leu 770 775 780Arg Leu Leu Pro Cys Cys Cys
Lys Thr Leu Ala Phe Leu Ala Val Met785 790 795 800Ser Val Gly Ala
His Thr Val Ser Ala Tyr Glu His Val Thr Val Ile 805 810 815Pro Asn
Thr Val Gly Val Pro Tyr Lys Thr Leu Val Asn Arg Pro Gly 820 825
830Tyr Ser Pro Met Val Leu Glu Met Glu Leu Leu Ser Val Thr Leu Glu
835 840 845Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys Glu Tyr Lys Thr
Val Ile 850 855 860Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr Ala Glu
Cys Lys Asp Lys865 870 875 880Asn Leu Pro Asp Tyr Ser Cys Lys Val
Phe Thr Gly Val Tyr Pro Phe 885 890 895Met Trp Gly Gly Ala Tyr Cys
Phe Cys Asp Ala Glu Asn Thr Gln Leu 900 905 910Ser Glu Ala His Val
Glu Lys Ser Glu Ser Cys Lys Thr Glu Phe Ala 915 920 925Ser Ala Tyr
Arg Ala His Thr Ala Ser Ala Ser Ala Lys Leu Arg Val 930 935 940Leu
Tyr Gln Gly Asn Asn Ile Thr Val Thr Ala Tyr Ala Asn Gly Asp945 950
955 960His Ala Val Thr Val Lys Asp Ala Lys Phe Ile Val Gly Pro Met
Ser 965 970 975Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile Val Val Tyr
Lys Gly Asp 980 985 990Val Tyr Asn Met Asp Tyr Pro Pro Phe Gly Ala
Gly Arg Pro Gly Gln 995 1000 1005Phe Gly Asp Ile Gln Ser Arg Thr
Pro Glu Ser Lys Asp Val Tyr 1010 1015 1020Ala Asn Thr Gln Leu Val
Leu Gln Arg Pro Ala Ala Gly Thr Val 1025 1030 1035His Val Pro Tyr
Ser Gln Ala Pro Ser Gly Phe Lys Tyr Trp Leu 1040 1045 1050Lys Glu
Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe Gly Cys 1055 1060
1065Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala Val Gly
1070 1075 1080Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe
Thr Arg 1085 1090 1095Val Val Asp Ala Pro Ser Leu Thr Asp Met Ser
Cys Glu Val Pro 1100 1105 1110Ala Cys Thr His Ser Ser Asp Phe Gly
Gly Val Ala Ile Ile Lys 1115 1120 1125Tyr Ala Ala Ser Lys Lys Gly
Lys Cys Ala Val His Ser Met Thr 1130 1135 1140Asn Ala Val Thr Ile
Arg Glu Ala Glu Ile Glu Val Glu Gly Asn 1145 1150 1155Ser Gln Leu
Gln Ile Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu 1160 1165 1170Phe
Arg Val Gln Val Cys Ser Thr Gln Val His Cys Ala Ala Glu 1175 1180
1185Cys His Pro Pro Lys Asp His Ile Val Asn Tyr Pro Ala Ser His
1190 1195 1200Thr Thr Leu Gly Val Gln Asp Ile Ser Ala Thr Ala Met
Ser Trp 1205 1210 1215Val Gln Lys Ile Thr Gly Gly Val Gly Leu Val
Val Ala Val Ala 1220 1225 1230Ala Leu Ile Leu Ile Val Val Leu Cys
Val Ser Phe Ser Arg His 1235
1240 1245251248PRTChikungunya virus 25Met Glu Phe Ile Pro Thr Gln
Thr Phe Tyr Asn Arg Arg Tyr Gln Pro1 5 10 15Arg Pro Trp Thr Pro Arg
Pro Thr Ile Gln Val Ile Arg Pro Arg Pro 20 25 30Arg Pro Gln Arg Gln
Ala Gly Gln Leu Ala Gln Leu Ile Ser Ala Val 35 40 45Asn Lys Leu Thr
Met Arg Ala Val Pro Gln Gln Lys Pro Arg Arg Asn 50 55 60Arg Lys Asn
Lys Lys Gln Lys Gln Lys Gln Gln Ala Pro Gln Asn Asn65 70 75 80Thr
Asn Gln Lys Lys Gln Pro Pro Lys Lys Lys Pro Ala Gln Lys Lys 85 90
95Lys Lys Pro Gly Arg Arg Glu Arg Met Cys Met Lys Ile Glu Asn Asp
100 105 110Cys Ile Phe Glu Val Lys His Glu Gly Lys Val Thr Gly Tyr
Ala Cys 115 120 125Leu Val Gly Asp Lys Val Met Lys Pro Ala His Val
Lys Gly Thr Ile 130 135 140Asp Asn Ala Asp Leu Ala Lys Leu Ala Phe
Lys Arg Ser Ser Lys Tyr145 150 155 160Asp Leu Glu Cys Ala Gln Ile
Pro Val His Met Lys Ser Asp Ala Ser 165 170 175Lys Phe Thr His Glu
Lys Pro Glu Gly Tyr Tyr Asn Trp His His Gly 180 185 190Ala Val Gln
Tyr Ser Gly Gly Arg Phe Thr Ile Pro Thr Gly Ala Gly 195 200 205Lys
Pro Gly Asp Ser Gly Arg Pro Ile Phe Asp Asn Lys Gly Arg Val 210 215
220Val Ala Ile Val Leu Gly Gly Ala Asn Glu Gly Ala Arg Thr Ala
Leu225 230 235 240Ser Val Val Thr Trp Asn Lys Asp Ile Val Thr Lys
Ile Thr Pro Glu 245 250 255Gly Ala Glu Glu Trp Ser Leu Ala Ile Pro
Val Met Cys Leu Leu Ala 260 265 270Asn Thr Thr Phe Pro Cys Ser Gln
Pro Pro Cys Thr Pro Cys Cys Tyr 275 280 285Glu Lys Glu Pro Glu Glu
Thr Leu Arg Met Leu Glu Asp Asn Val Met 290 295 300Arg Pro Gly Tyr
Tyr Gln Leu Leu Gln Ala Ser Leu Thr Cys Ser Pro305 310 315 320His
Arg Gln Arg Arg Ser Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala 325 330
335Thr Arg Pro Tyr Leu Ala His Cys Pro Asp Cys Gly Glu Gly His Ser
340 345 350Cys His Ser Pro Val Ala Leu Glu Arg Ile Arg Asn Glu Ala
Thr Asp 355 360 365Gly Thr Leu Lys Ile Gln Val Ser Leu Gln Ile Gly
Ile Lys Thr Asp 370 375 380Asp Ser His Asp Trp Thr Lys Leu Arg Tyr
Met Asp Asn His Met Pro385 390 395 400Ala Asp Ala Glu Arg Ala Gly
Leu Phe Val Arg Thr Ser Ala Pro Cys 405 410 415Thr Ile Thr Gly Thr
Met Gly His Phe Ile Leu Ala Arg Cys Pro Lys 420 425 430Gly Glu Thr
Leu Thr Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His 435 440 445Ser
Cys Thr His Pro Phe His His Asp Pro Pro Val Ile Gly Arg Glu 450 455
460Lys Phe His Ser Arg Pro Arg His Gly Lys Glu Leu Pro Cys Ser
Thr465 470 475 480Tyr Val Gln Ser Thr Ala Ala Thr Thr Glu Glu Ile
Glu Val His Met 485 490 495Pro Pro Asp Thr Pro Asp Arg Thr Leu Met
Ser Gln Gln Ser Gly Asn 500 505 510Val Lys Ile Thr Val Asn Gly Gln
Thr Val Arg Tyr Lys Cys Asn Cys 515 520 525Gly Gly Ser Asn Glu Gly
Leu Thr Thr Thr Asp Lys Val Ile Asn Asn 530 535 540Cys Lys Val Asp
Gln Cys His Ala Ala Val Thr Asn His Lys Lys Trp545 550 555 560Gln
Tyr Asn Ser Pro Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg 565 570
575Lys Gly Lys Ile His Ile Pro Phe Pro Leu Ala Asn Val Thr Cys Arg
580 585 590Val Pro Lys Ala Arg Asn Pro Thr Val Thr Tyr Gly Lys Asn
Gln Val 595 600 605Ile Met Leu Leu Tyr Pro Asp His Pro Thr Leu Leu
Ser Tyr Arg Asn 610 615 620Met Gly Glu Glu Pro Asn Tyr Gln Glu Glu
Trp Val Met His Lys Lys625 630 635 640Glu Val Val Leu Thr Val Pro
Thr Glu Gly Leu Glu Val Thr Trp Gly 645 650 655Asn Asn Glu Pro Tyr
Lys Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr 660 665 670Ala His Gly
His Pro His Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr 675 680 685Pro
Thr Met Thr Val Val Val Val Ser Val Ala Thr Phe Ile Leu Leu 690 695
700Ser Met Val Gly Met Ala Ala Gly Met Cys Met Cys Ala Arg Arg
Arg705 710 715 720Cys Ile Thr Pro Tyr Glu Leu Thr Pro Gly Ala Thr
Val Pro Phe Leu 725 730 735Leu Ser Leu Ile Cys Cys Ile Arg Thr Ala
Lys Ala Ala Thr Tyr Gln 740 745 750Glu Ala Ala Ile Tyr Leu Trp Asn
Glu Gln Gln Pro Leu Phe Trp Leu 755 760 765Gln Ala Leu Ile Pro Leu
Ala Ala Leu Ile Val Leu Cys Asn Cys Leu 770 775 780Arg Leu Leu Pro
Cys Cys Cys Lys Thr Leu Ala Phe Leu Ala Val Met785 790 795 800Ser
Val Gly Ala His Thr Val Ser Ala Tyr Glu His Val Thr Val Ile 805 810
815Pro Asn Thr Val Gly Val Pro Tyr Lys Thr Leu Val Asn Arg Pro Gly
820 825 830Tyr Ser Pro Met Val Leu Glu Met Glu Leu Leu Ser Val Thr
Leu Glu 835 840 845Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys Glu Tyr
Lys Thr Val Ile 850 855 860Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr
Ala Glu Cys Lys Asp Lys865 870 875 880Asn Leu Pro Asp Tyr Ser Cys
Lys Val Phe Thr Gly Val Tyr Pro Phe 885 890 895Met Trp Gly Gly Ala
Tyr Cys Phe Cys Asp Ala Glu Asn Thr Gln Leu 900 905 910Ser Glu Ala
His Val Glu Lys Ser Glu Ser Cys Lys Thr Glu Phe Ala 915 920 925Ser
Ala Tyr Arg Ala His Thr Ala Ser Ala Ser Ala Lys Leu Arg Val 930 935
940Leu Tyr Gln Gly Asn Asn Ile Thr Val Thr Ala Tyr Ala Asn Gly
Asp945 950 955 960His Ala Val Thr Val Lys Asp Ala Lys Phe Ile Val
Gly Pro Met Ser 965 970 975Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile
Val Val Tyr Lys Gly Asp 980 985 990Val Tyr Asn Met Asp Tyr Pro Pro
Phe Gly Ala Gly Arg Pro Gly Gln 995 1000 1005Phe Gly Asp Ile Gln
Ser Arg Thr Pro Glu Ser Lys Asp Val Tyr 1010 1015 1020Ala Asn Thr
Gln Leu Val Leu Gln Arg Pro Ala Ala Gly Thr Val 1025 1030 1035His
Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe Lys Tyr Trp Leu 1040 1045
1050Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe Gly Cys
1055 1060 1065Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala
Val Gly 1070 1075 1080Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala
Ala Phe Thr Arg 1085 1090 1095Val Val Asp Ala Pro Ser Leu Thr Asp
Met Ser Cys Glu Val Pro 1100 1105 1110Ala Cys Thr His Ser Ser Asp
Phe Gly Gly Val Ala Ile Ile Lys 1115 1120 1125Tyr Ala Ala Ser Lys
Lys Gly Lys Cys Ala Val His Ser Met Thr 1130 1135 1140Asn Ala Val
Thr Ile Arg Glu Ala Glu Ile Glu Val Glu Gly Asn 1145 1150 1155Ser
Gln Leu Gln Ile Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu 1160 1165
1170Phe Arg Val Gln Val Cys Ser Thr Gln Val His Cys Ala Ala Glu
1175 1180 1185Cys His Pro Pro Lys Asp His Ile Val Asn Tyr Pro Ala
Ser His 1190 1195 1200Thr Thr Leu Gly Val Gln Asp Ile Ser Ala Thr
Ala Met Ser Trp 1205 1210 1215Val Gln Lys Ile Thr Gly Gly Val Gly
Leu Val Val Ala Val Ala 1220 1225 1230Ala Leu Ile Leu Ile Val Val
Leu Cys Val Ser Phe Ser Arg His 1235 1240 1245261248PRTChikungunya
virus 26Met Glu Phe Ile Pro Thr Gln Thr Phe Tyr Asn Arg Arg Tyr Gln
Pro1 5 10 15Arg Pro Trp Thr Pro Arg Pro Thr Ile Gln Val Ile Arg Pro
Arg Pro 20 25 30Arg Pro Gln Arg Gln Ala Gly Gln Leu Ala Gln Leu Ile
Ser Ala Val 35 40 45Asn Lys Leu Thr Met Arg Ala Val Pro Gln Gln Lys
Pro Arg Arg Asn 50 55 60Arg Lys Asn Lys Lys Gln Lys Gln Lys Gln Gln
Ala Pro Gln Asn Asn65 70 75 80Thr Asn Gln Lys Lys Gln Pro Pro Lys
Lys Lys Pro Ala Gln Lys Lys 85 90 95Lys Lys Pro Gly Arg Arg Glu Arg
Met Cys Met Lys Ile Glu Asn Asp 100 105 110Cys Ile Phe Glu Val Lys
His Glu Gly Lys Val Thr Gly Tyr Ala Cys 115 120 125Leu Val Gly Asp
Lys Val Met Lys Pro Ala His Val Lys Gly Thr Ile 130 135 140Asp Asn
Ala Asp Leu Ala Lys Leu Ala Phe Lys Arg Ser Ser Lys Tyr145 150 155
160Asp Leu Glu Cys Ala Gln Ile Pro Val His Met Lys Ser Asp Ala Ser
165 170 175Lys Phe Thr His Glu Lys Pro Glu Gly Tyr Tyr Asn Trp His
His Gly 180 185 190Ala Val Gln Tyr Ser Gly Gly Arg Phe Thr Ile Pro
Thr Gly Ala Gly 195 200 205Lys Pro Gly Asp Ser Gly Arg Pro Ile Phe
Asp Asn Lys Gly Arg Val 210 215 220Val Ala Ile Val Leu Gly Gly Ala
Asn Glu Gly Ala Arg Thr Ala Leu225 230 235 240Ser Val Val Thr Trp
Asn Lys Asp Ile Val Thr Lys Ile Thr Pro Glu 245 250 255Gly Ala Glu
Glu Trp Ser Leu Ala Ile Pro Val Met Cys Leu Leu Ala 260 265 270Asn
Thr Thr Phe Pro Cys Ser Gln Pro Pro Cys Thr Pro Cys Cys Tyr 275 280
285Glu Lys Glu Pro Glu Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met
290 295 300Arg Pro Gly Tyr Tyr Gln Leu Leu Gln Ala Ser Leu Thr Cys
Ser Pro305 310 315 320His Arg Gln Arg Arg Ser Thr Lys Asp Asn Phe
Asn Val Tyr Lys Ala 325 330 335Thr Arg Pro Tyr Leu Ala His Cys Pro
Asp Cys Gly Glu Gly His Ser 340 345 350Cys His Ser Pro Val Ala Leu
Glu Arg Ile Arg Asn Glu Ala Thr Asp 355 360 365Gly Thr Leu Lys Ile
Gln Val Ser Leu Gln Ile Gly Ile Lys Thr Asp 370 375 380Asp Ser His
Asp Trp Thr Lys Leu Arg Tyr Met Asp Asn His Met Pro385 390 395
400Ala Asp Ala Glu Arg Ala Gly Leu Phe Val Arg Thr Ser Ala Pro Cys
405 410 415Thr Ile Thr Gly Thr Met Gly His Phe Ile Leu Ala Arg Cys
Pro Lys 420 425 430Gly Glu Thr Leu Thr Val Gly Phe Thr Asp Ser Arg
Lys Ile Ser His 435 440 445Ser Cys Thr His Pro Phe His His Asp Pro
Pro Val Ile Gly Arg Glu 450 455 460Lys Phe His Ser Arg Pro Gln His
Gly Lys Glu Leu Pro Cys Ser Thr465 470 475 480Tyr Val Gln Ser Thr
Ala Ala Thr Thr Glu Glu Ile Glu Val His Met 485 490 495Pro Pro Asp
Thr Pro Asp Arg Thr Leu Met Ser Gln Gln Ser Gly Asn 500 505 510Val
Lys Ile Thr Val Asn Gly Gln Thr Val Arg Tyr Lys Cys Asn Cys 515 520
525Gly Gly Ser Asn Glu Gly Leu Thr Thr Thr Asp Lys Val Ile Asn Asn
530 535 540Cys Lys Val Asp Gln Cys His Ala Ala Val Thr Asn His Lys
Lys Trp545 550 555 560Gln Tyr Asn Ser Pro Leu Val Pro Arg Asn Ala
Glu Leu Gly Asp Arg 565 570 575Lys Gly Lys Ile His Ile Pro Phe Pro
Leu Ala Asn Val Thr Cys Arg 580 585 590Val Pro Lys Ala Arg Asn Pro
Thr Val Thr Tyr Gly Lys Asn Gln Val 595 600 605Ile Met Leu Leu Tyr
Pro Asp His Pro Thr Leu Leu Ser Tyr Arg Asn 610 615 620Met Gly Glu
Glu Pro Asn Tyr Gln Glu Glu Trp Val Met His Lys Lys625 630 635
640Glu Val Val Leu Thr Val Pro Thr Glu Gly Leu Glu Val Thr Trp Gly
645 650 655Asn Asn Glu Pro Tyr Lys Tyr Trp Pro Gln Leu Ser Thr Asn
Gly Thr 660 665 670Ala His Gly His Pro His Glu Ile Ile Leu Tyr Tyr
Tyr Glu Leu Tyr 675 680 685Pro Thr Met Thr Val Val Val Val Ser Val
Ala Thr Phe Ile Leu Leu 690 695 700Ser Met Val Gly Met Ala Ala Gly
Met Cys Met Cys Ala Arg Arg Arg705 710 715 720Cys Ile Thr Pro Tyr
Glu Leu Thr Pro Gly Ala Thr Val Pro Phe Leu 725 730 735Leu Ser Leu
Ile Cys Cys Ile Arg Thr Ala Lys Ala Ala Thr Tyr Gln 740 745 750Glu
Ala Ala Ile Tyr Leu Trp Asn Glu Gln Gln Pro Leu Phe Trp Leu 755 760
765Gln Ala Leu Ile Pro Leu Ala Ala Leu Ile Val Leu Cys Asn Cys Leu
770 775 780Arg Leu Leu Pro Cys Cys Cys Lys Thr Leu Ala Phe Leu Ala
Val Met785 790 795 800Ser Val Gly Ala His Thr Val Ser Ala Tyr Glu
His Val Thr Val Ile 805 810 815Pro Asn Thr Val Gly Val Pro Tyr Lys
Thr Leu Val Asn Arg Pro Gly 820 825 830Tyr Ser Pro Met Val Leu Glu
Met Glu Leu Leu Ser Val Thr Leu Glu 835 840 845Pro Thr Leu Ser Leu
Asp Tyr Ile Thr Cys Glu Tyr Lys Thr Val Ile 850 855 860Pro Ser Pro
Tyr Val Lys Cys Cys Gly Thr Ala Glu Cys Lys Asp Lys865 870 875
880Asn Leu Pro Asp Tyr Ser Cys Lys Val Phe Thr Gly Val Tyr Pro Phe
885 890 895Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Ala Glu Asn Thr
Gln Leu 900 905 910Ser Glu Ala His Val Glu Lys Ser Glu Ser Cys Lys
Thr Glu Phe Ala 915 920 925Ser Ala Tyr Arg Ala His Thr Ala Ser Ala
Ser Ala Lys Leu Arg Val 930 935 940Leu Tyr Gln Gly Asn Asn Ile Thr
Val Thr Ala Tyr Ala Asn Gly Asp945 950 955 960His Ala Val Thr Val
Lys Asp Ala Lys Phe Ile Val Gly Pro Met Ser 965 970 975Ser Ala Trp
Thr Pro Phe Asp Asn Lys Ile Val Val Tyr Lys Gly Asp 980 985 990Val
Tyr Asn Met Asp Tyr Pro Pro Phe Gly Ala Gly Arg Pro Gly Gln 995
1000 1005Phe Gly Asp Ile Gln Ser Arg Thr Pro Glu Ser Lys Asp Val
Tyr 1010 1015 1020Ala Asn Thr Gln Leu Val Leu Gln Arg Pro Ala Ala
Gly Thr Val 1025 1030 1035His Val Pro Tyr Ser Gln Ala Pro Ser Gly
Phe Lys Tyr Trp Leu 1040 1045 1050Lys Glu Arg Gly Ala Ser Leu Gln
His Thr Ala Pro Phe Gly Cys 1055 1060 1065Gln Ile Ala Thr Asn Pro
Val Arg Ala Val Asn Cys Ala Val Gly 1070 1075 1080Asn Met Pro Ile
Ser Ile Asp Ile Pro Glu Ala Ala Phe Thr Arg 1085 1090 1095Val Val
Asp Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Pro 1100 1105
1110Ala Cys Thr His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys
1115 1120 1125Tyr Ala Ala Ser Lys Lys Gly Lys Cys Ala Val His Ser
Met Thr 1130 1135 1140Asn Ala Val Thr Ile Arg Glu Ala Glu Ile Glu
Val Glu Gly Asn 1145 1150 1155Ser Gln Leu Gln Ile Ser Phe Ser Thr
Ala Leu Ala Ser Ala Glu 1160 1165 1170Phe Arg Val Gln Val Cys Ser
Thr Gln Val His Cys Ala Ala Glu 1175 1180 1185Cys His Pro Pro Lys
Asp His Ile Val Asn Tyr Pro Ala Ser His 1190 1195 1200Thr Thr
Leu Gly Val Gln Asp Ile Ser Ala Thr Ala Met Ser Trp 1205 1210
1215Val Gln Lys Ile Thr Gly Gly Val Gly Leu Val Val Ala Val Ala
1220 1225 1230Ala Leu Ile Leu Ile Val Val Leu Cys Val Ser Phe Ser
Arg His 1235 1240 1245271248PRTChikungunya virus 27Met Glu Phe Ile
Pro Thr Gln Thr Phe Tyr Asn Arg Arg Tyr Gln Pro1 5 10 15Arg Pro Trp
Thr Pro Arg Pro Thr Ile Gln Val Ile Arg Pro Arg Pro 20 25 30Arg Pro
Gln Arg Gln Ala Gly Gln Leu Ala Gln Leu Ile Ser Ala Val 35 40 45Asn
Lys Leu Thr Met Arg Ala Val Pro Gln Gln Lys Pro Arg Arg Asn 50 55
60Arg Lys Asn Lys Lys Gln Lys Gln Lys Gln Gln Ala Pro Gln Asn Asn65
70 75 80Thr Asn Gln Lys Lys Gln Pro Pro Lys Lys Lys Pro Ala Gln Lys
Lys 85 90 95Lys Lys Pro Gly Arg Arg Glu Arg Met Cys Met Lys Ile Glu
Asn Asp 100 105 110Cys Ile Phe Glu Val Lys His Glu Gly Lys Val Thr
Gly Tyr Ala Cys 115 120 125Leu Val Gly Asp Lys Val Met Lys Pro Ala
His Val Lys Gly Thr Ile 130 135 140Asp Asn Ala Asp Leu Ala Lys Leu
Ala Phe Lys Arg Ser Ser Lys Tyr145 150 155 160Asp Leu Glu Cys Ala
Gln Ile Pro Val His Met Lys Ser Asp Ala Ser 165 170 175Lys Phe Thr
His Glu Lys Pro Glu Gly Tyr Tyr Asn Trp His His Gly 180 185 190Ala
Val Gln Tyr Ser Gly Gly Arg Phe Thr Ile Pro Thr Gly Ala Gly 195 200
205Lys Pro Gly Asp Ser Gly Arg Pro Ile Phe Asp Asn Lys Gly Arg Val
210 215 220Val Ala Ile Val Leu Gly Gly Ala Asn Glu Gly Ala Arg Thr
Ala Leu225 230 235 240Ser Val Val Thr Trp Asn Lys Asp Ile Val Thr
Lys Ile Thr Pro Glu 245 250 255Gly Ala Glu Glu Trp Ser Leu Ala Ile
Pro Val Met Cys Leu Leu Ala 260 265 270Asn Thr Thr Phe Pro Cys Ser
Gln Pro Pro Cys Thr Pro Cys Cys Tyr 275 280 285Glu Lys Glu Pro Glu
Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met 290 295 300Arg Pro Gly
Tyr Tyr Gln Leu Leu Gln Ala Ser Leu Thr Cys Ser Pro305 310 315
320His Arg Gln Arg Arg Ser Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala
325 330 335Thr Arg Pro Tyr Leu Ala His Cys Pro Asp Cys Gly Glu Gly
His Ser 340 345 350Cys His Ser Pro Val Ala Leu Glu Arg Ile Arg Asn
Glu Ala Thr Asp 355 360 365Gly Thr Leu Lys Ile Gln Val Ser Leu Gln
Ile Gly Ile Lys Thr Asp 370 375 380Asp Ser His Asp Trp Thr Lys Leu
Arg Tyr Met Asp Asn His Met Pro385 390 395 400Ala Asp Ala Glu Arg
Ala Gly Leu Phe Val Arg Thr Ser Ala Pro Cys 405 410 415Thr Ile Thr
Gly Thr Met Gly His Phe Ile Leu Ala Arg Cys Pro Lys 420 425 430Gly
Glu Thr Leu Thr Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His 435 440
445Ser Cys Thr His Pro Phe His His Asp Pro Pro Val Ile Gly Arg Glu
450 455 460Lys Phe His Ser Arg Pro Gln His Gly Lys Glu Leu Pro Cys
Ser Thr465 470 475 480Tyr Val Gln Ser Thr Ala Ala Thr Thr Glu Glu
Ile Glu Val His Met 485 490 495Pro Pro Asp Thr Pro Asp Arg Thr Leu
Met Ser Gln Gln Ser Gly Asn 500 505 510Val Lys Ile Thr Val Asn Gly
Gln Thr Val Arg Tyr Lys Cys Asn Cys 515 520 525Gly Gly Ser Asn Glu
Gly Leu Thr Thr Thr Asp Lys Val Ile Asn Asn 530 535 540Cys Lys Val
Asp Gln Cys His Ala Ala Val Thr Asn His Lys Lys Trp545 550 555
560Gln Tyr Asn Ser Pro Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg
565 570 575Lys Gly Lys Ile His Ile Pro Phe Pro Leu Ala Asn Val Thr
Cys Arg 580 585 590Val Pro Lys Ala Arg Asn Pro Thr Val Thr Tyr Gly
Lys Asn Gln Val 595 600 605Ile Met Leu Leu Tyr Pro Asp His Pro Thr
Leu Leu Ser Tyr Arg Asn 610 615 620Met Gly Glu Glu Pro Asn Tyr Gln
Glu Glu Trp Val Met His Lys Lys625 630 635 640Glu Val Val Leu Thr
Val Pro Thr Glu Gly Leu Glu Val Thr Trp Gly 645 650 655Asn Asn Glu
Pro Tyr Lys Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr 660 665 670Ala
His Gly His Pro His Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr 675 680
685Pro Thr Met Thr Val Val Val Val Ser Val Ala Thr Phe Ile Leu Leu
690 695 700Ser Met Val Gly Met Ala Ala Gly Met Cys Met Cys Ala Arg
Arg Arg705 710 715 720Cys Ile Thr Pro Tyr Glu Leu Thr Pro Gly Ala
Thr Val Pro Phe Leu 725 730 735Leu Ser Leu Ile Cys Cys Ile Arg Thr
Ala Lys Ala Ala Thr Tyr Gln 740 745 750Glu Ala Ala Ile Tyr Leu Trp
Asn Glu Gln Gln Pro Leu Phe Trp Leu 755 760 765Gln Ala Leu Ile Pro
Leu Ala Ala Leu Ile Val Leu Cys Asn Cys Leu 770 775 780Arg Leu Leu
Pro Cys Cys Cys Lys Thr Leu Ala Phe Leu Ala Val Met785 790 795
800Ser Val Gly Ala His Thr Val Ser Ala Tyr Glu His Val Thr Val Ile
805 810 815Pro Asn Thr Val Gly Val Pro Tyr Lys Thr Leu Val Asn Arg
Pro Gly 820 825 830Tyr Ser Pro Met Val Leu Glu Met Glu Leu Leu Ser
Val Thr Leu Glu 835 840 845Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys
Glu Tyr Lys Thr Val Ile 850 855 860Pro Ser Pro Tyr Val Lys Cys Cys
Gly Thr Ala Glu Cys Lys Asp Lys865 870 875 880Asn Leu Pro Asp Tyr
Ser Cys Lys Val Phe Thr Gly Val Tyr Pro Phe 885 890 895Met Trp Gly
Gly Ala Tyr Cys Phe Cys Asp Ala Glu Asn Thr Gln Leu 900 905 910Ser
Glu Ala His Val Glu Lys Ser Glu Ser Cys Lys Thr Glu Phe Ala 915 920
925Ser Ala Tyr Arg Ala His Thr Ala Ser Ala Ser Ala Lys Leu Arg Val
930 935 940Leu Tyr Gln Gly Asn Asn Ile Thr Val Thr Ala Tyr Ala Asn
Gly Asp945 950 955 960His Ala Val Thr Val Lys Asp Ala Lys Phe Ile
Val Gly Pro Met Ser 965 970 975Ser Ala Trp Thr Pro Phe Asp Asn Lys
Ile Val Val Tyr Lys Gly Asp 980 985 990Val Tyr Asn Met Asp Tyr Pro
Pro Phe Gly Ala Gly Arg Pro Gly Gln 995 1000 1005Phe Gly Asp Ile
Gln Ser Arg Thr Pro Glu Ser Lys Asp Val Tyr 1010 1015 1020Ala Asn
Thr Gln Leu Val Leu Gln Arg Pro Ala Val Gly Thr Val 1025 1030
1035His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe Lys Tyr Trp Leu
1040 1045 1050Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe
Gly Cys 1055 1060 1065Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn
Cys Ala Val Gly 1070 1075 1080Asn Met Pro Ile Ser Ile Asp Ile Pro
Glu Ala Ala Phe Thr Arg 1085 1090 1095Val Val Asp Ala Pro Ser Leu
Thr Asp Met Ser Cys Glu Val Pro 1100 1105 1110Ala Cys Thr His Ser
Ser Asp Phe Gly Gly Val Ala Ile Ile Lys 1115 1120 1125Tyr Ala Ala
Ser Lys Lys Gly Lys Cys Ala Val His Ser Met Thr 1130 1135 1140Asn
Ala Val Thr Ile Arg Glu Ala Glu Ile Glu Val Glu Gly Asn 1145 1150
1155Ser Gln Leu Gln Ile Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu
1160 1165 1170Phe Arg Val Gln Val Cys Ser Thr Gln Val His Cys Ala
Ala Glu 1175 1180 1185Cys His Pro Pro Lys Asp His Ile Val Asn Tyr
Pro Ala Ser His 1190 1195 1200Thr Thr Leu Gly Val Gln Asp Ile Ser
Ala Thr Ala Met Ser Trp 1205 1210 1215Val Gln Lys Ile Thr Gly Gly
Val Gly Leu Val Val Ala Val Ala 1220 1225 1230Ala Leu Ile Leu Ile
Val Val Leu Cys Val Ser Phe Ser Arg His 1235 1240
1245281248PRTChikungunya virus 28Met Glu Phe Ile Pro Thr Gln Thr
Phe Tyr Asn Arg Arg Tyr Gln Pro1 5 10 15Arg Pro Trp Thr Pro Arg Pro
Thr Ile Gln Val Ile Arg Pro Arg Pro 20 25 30Arg Pro Gln Arg Gln Ala
Gly Gln Leu Ala Gln Leu Ile Ser Ala Val 35 40 45Asn Lys Leu Thr Met
Arg Ala Val Pro Gln Gln Lys Pro Arg Arg Asn 50 55 60Arg Lys Asn Lys
Lys Gln Lys Gln Lys Gln Gln Ala Pro Gln Asn Asn65 70 75 80Thr Asn
Gln Lys Lys Gln Pro Pro Lys Lys Lys Pro Ala Gln Lys Lys 85 90 95Lys
Lys Pro Gly Arg Arg Glu Arg Met Cys Met Lys Ile Glu Asn Asp 100 105
110Cys Ile Phe Glu Val Lys His Glu Gly Lys Val Thr Gly Tyr Ala Cys
115 120 125Leu Val Gly Asp Lys Val Met Lys Pro Ala His Val Lys Gly
Thr Ile 130 135 140Asp Asn Ala Asp Leu Ala Lys Leu Ala Phe Lys Arg
Ser Ser Lys Tyr145 150 155 160Asp Leu Glu Cys Ala Gln Ile Pro Val
His Met Lys Ser Asp Ala Ser 165 170 175Lys Phe Thr His Glu Lys Pro
Glu Gly Tyr Tyr Asn Trp His His Gly 180 185 190Ala Val Gln Tyr Ser
Gly Gly Arg Phe Thr Ile Pro Thr Gly Ala Gly 195 200 205Lys Pro Gly
Asp Ser Gly Arg Pro Ile Phe Asp Asn Lys Gly Arg Val 210 215 220Val
Ala Ile Val Leu Gly Gly Ala Asn Glu Gly Ala Arg Thr Ala Leu225 230
235 240Ser Val Val Thr Trp Asn Lys Asp Ile Val Thr Lys Ile Thr Pro
Glu 245 250 255Gly Ala Glu Glu Trp Ser Leu Ala Ile Pro Val Met Cys
Leu Leu Ala 260 265 270Asn Thr Thr Phe Pro Cys Ser Gln Pro Pro Cys
Thr Pro Cys Cys Tyr 275 280 285Glu Lys Glu Pro Glu Glu Thr Leu Arg
Met Leu Glu Asp Asn Val Met 290 295 300Arg Pro Gly Tyr Tyr Gln Leu
Leu Gln Ala Ser Leu Thr Cys Ser Pro305 310 315 320His Arg Gln Arg
Arg Ser Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala 325 330 335Thr Arg
Pro Tyr Leu Ala His Cys Pro Asp Cys Gly Glu Gly His Ser 340 345
350Cys His Ser Pro Val Ala Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp
355 360 365Gly Thr Leu Lys Ile Gln Val Ser Leu Gln Ile Gly Ile Lys
Thr Asp 370 375 380Asp Ser His Asp Trp Thr Lys Leu Arg Tyr Met Asp
Asn His Met Pro385 390 395 400Ala Asp Ala Glu Arg Ala Gly Leu Phe
Val Arg Thr Ser Ala Pro Cys 405 410 415Thr Ile Thr Gly Thr Met Gly
His Phe Ile Leu Ala Arg Cys Pro Lys 420 425 430Gly Glu Thr Leu Thr
Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His 435 440 445Ser Cys Thr
His Pro Phe His His Asp Pro Pro Val Ile Gly Arg Glu 450 455 460Lys
Phe His Ser Arg Pro Gln His Gly Lys Glu Leu Pro Cys Ser Thr465 470
475 480Tyr Val Gln Ser Thr Ala Ala Thr Thr Glu Glu Ile Glu Val His
Met 485 490 495Pro Pro Asp Thr Pro Asp Arg Thr Leu Met Ser Gln Gln
Ser Gly Asn 500 505 510Val Lys Ile Thr Val Asn Gly Gln Thr Val Arg
Tyr Lys Cys Asn Cys 515 520 525Gly Gly Ser Asn Glu Gly Leu Thr Thr
Thr Asp Lys Val Ile Asn Asn 530 535 540Cys Lys Val Asp Gln Cys His
Ala Ala Val Thr Asn His Lys Lys Trp545 550 555 560Gln Tyr Asn Ser
Pro Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg 565 570 575Lys Gly
Lys Ile His Ile Pro Phe Pro Leu Ala Asn Val Thr Cys Arg 580 585
590Val Pro Lys Ala Arg Asn Pro Thr Val Thr Tyr Gly Lys Asn Gln Val
595 600 605Ile Met Leu Leu Tyr Pro Asp His Pro Thr Leu Leu Ser Tyr
Arg Asn 610 615 620Met Gly Glu Glu Pro Asn Tyr Gln Glu Glu Trp Val
Met His Lys Lys625 630 635 640Glu Val Val Leu Thr Val Pro Thr Glu
Gly Leu Glu Val Thr Trp Gly 645 650 655Asn Asn Glu Pro Tyr Lys Tyr
Trp Pro Gln Leu Ser Thr Asn Gly Thr 660 665 670Ala His Gly His Pro
His Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr 675 680 685Pro Thr Met
Thr Val Val Val Val Ser Val Ala Thr Phe Ile Leu Leu 690 695 700Ser
Met Val Gly Met Ala Ala Gly Met Cys Met Cys Ala Arg Arg Arg705 710
715 720Cys Ile Thr Pro Tyr Glu Leu Thr Pro Gly Ala Thr Val Pro Phe
Leu 725 730 735Leu Ser Leu Ile Cys Cys Ile Arg Thr Ala Lys Ala Ala
Thr Tyr Gln 740 745 750Glu Ala Ala Ile Tyr Leu Trp Asn Glu Gln Gln
Pro Leu Phe Trp Leu 755 760 765Gln Ala Leu Ile Pro Leu Ala Ala Leu
Ile Val Leu Cys Asn Cys Leu 770 775 780Arg Leu Leu Pro Cys Cys Cys
Lys Thr Leu Ala Phe Leu Ala Val Met785 790 795 800Ser Val Gly Ala
His Thr Val Ser Ala Tyr Glu His Val Thr Val Ile 805 810 815Pro Asn
Thr Val Gly Val Pro Tyr Lys Thr Leu Val Asn Arg Pro Gly 820 825
830Tyr Ser Pro Met Val Leu Glu Met Glu Leu Leu Ser Val Thr Leu Glu
835 840 845Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys Glu Tyr Lys Thr
Val Ile 850 855 860Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr Ala Glu
Cys Lys Asp Lys865 870 875 880Asn Leu Pro Asp Tyr Ser Cys Lys Val
Phe Thr Gly Val Tyr Pro Phe 885 890 895Met Trp Gly Gly Ala Tyr Cys
Phe Cys Asp Ala Glu Asn Thr Gln Leu 900 905 910Ser Glu Ala His Val
Glu Lys Ser Glu Ser Cys Lys Thr Glu Phe Ala 915 920 925Ser Ala Tyr
Arg Ala His Thr Ala Ser Ala Ser Ala Lys Leu Arg Val 930 935 940Leu
Tyr Gln Gly Asn Asn Ile Thr Val Thr Ala Tyr Ala Asn Gly Asp945 950
955 960His Ala Val Thr Val Lys Asp Ala Lys Phe Ile Val Gly Pro Met
Ser 965 970 975Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile Val Val Tyr
Lys Gly Asp 980 985 990Val Tyr Asn Met Asp Tyr Pro Pro Phe Gly Ala
Gly Arg Pro Gly Gln 995 1000 1005Phe Gly Asp Ile Gln Ser Arg Thr
Pro Glu Ser Lys Asp Val Tyr 1010 1015 1020Ala Asn Thr Gln Leu Val
Leu Gln Arg Pro Ala Val Gly Thr Val 1025 1030 1035His Val Pro Tyr
Ser Gln Ala Pro Ser Gly Phe Lys Tyr Trp Leu 1040 1045 1050Lys Glu
Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe Gly Cys 1055 1060
1065Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala Val Gly
1070 1075 1080Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe
Thr Arg 1085 1090 1095Val Val Asp Ala Pro Ser Leu Thr Asp Met Ser
Cys Glu Val Pro 1100 1105 1110Ala Cys Thr His Ser Ser Asp Phe Gly
Gly Val Ala Ile Ile Lys 1115 1120 1125Tyr Ala Ala Ser Lys Lys Gly
Lys Cys Ala Val His Ser Met Thr 1130 1135 1140Asn Ala Val Thr Ile
Arg Glu Ala Glu Ile Glu Val Glu Gly Asn 1145 1150 1155Ser Gln Leu
Gln Ile Ser Phe Ser Thr Ala Leu Ala Ser
Ala Glu 1160 1165 1170Phe Arg Val Gln Val Cys Ser Thr Gln Val His
Cys Ala Ala Glu 1175 1180 1185Cys His Pro Pro Lys Asp His Ile Val
Asn Tyr Pro Ala Ser His 1190 1195 1200Thr Thr Leu Gly Val Gln Asp
Ile Ser Ala Thr Ala Met Ser Trp 1205 1210 1215Val Gln Lys Ile Thr
Gly Gly Val Gly Leu Val Val Ala Val Ala 1220 1225 1230Ala Leu Ile
Leu Ile Val Val Leu Cys Val Ser Phe Ser Arg His 1235 1240
1245291248PRTChikungunya virus 29Met Glu Phe Ile Pro Thr Gln Thr
Phe Tyr Asn Arg Arg Tyr Gln Pro1 5 10 15Arg Pro Trp Thr Pro Arg Pro
Thr Ile Gln Val Ile Arg Pro Arg Pro 20 25 30Arg Pro Gln Arg Gln Ala
Gly Gln Leu Ala Gln Leu Ile Ser Ala Val 35 40 45Asn Lys Leu Thr Met
Arg Ala Val Pro Gln Gln Lys Pro Arg Arg Asn 50 55 60Arg Lys Asn Lys
Lys Gln Lys Gln Lys Gln Gln Ala Pro Gln Asn Asn65 70 75 80Thr Asn
Gln Lys Lys Gln Pro Pro Lys Lys Lys Pro Ala Gln Lys Lys 85 90 95Lys
Lys Pro Gly Arg Arg Glu Arg Met Cys Met Lys Ile Glu Asn Asp 100 105
110Cys Ile Phe Glu Val Lys His Glu Gly Lys Val Thr Gly Tyr Ala Cys
115 120 125Leu Val Gly Asp Lys Val Met Lys Pro Ala His Val Lys Gly
Thr Ile 130 135 140Asp Asn Ala Asp Leu Ala Lys Leu Ala Phe Lys Arg
Ser Ser Lys Tyr145 150 155 160Asp Leu Glu Cys Ala Gln Ile Pro Val
His Met Lys Ser Asp Ala Ser 165 170 175Lys Phe Thr His Glu Lys Pro
Glu Gly Tyr Tyr Asn Trp His His Gly 180 185 190Ala Val Gln Tyr Ser
Gly Gly Arg Phe Thr Ile Pro Thr Gly Ala Gly 195 200 205Lys Pro Gly
Asp Ser Gly Arg Pro Ile Phe Asp Asn Lys Gly Arg Val 210 215 220Val
Ala Ile Val Leu Gly Gly Ala Asn Glu Gly Ala Arg Thr Ala Leu225 230
235 240Ser Val Val Thr Trp Asn Lys Asp Ile Val Thr Lys Ile Thr Pro
Glu 245 250 255Gly Ala Glu Glu Trp Ser Leu Ala Ile Pro Val Met Cys
Leu Leu Ala 260 265 270Asn Thr Thr Phe Pro Cys Ser Gln Pro Pro Cys
Thr Pro Cys Cys Tyr 275 280 285Glu Lys Glu Pro Glu Glu Thr Leu Arg
Met Leu Glu Asp Asn Val Met 290 295 300Arg Pro Gly Tyr Tyr Gln Leu
Leu Gln Ala Ser Leu Thr Cys Ser Pro305 310 315 320His Arg Gln Arg
Arg Ser Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala 325 330 335Thr Arg
Pro Tyr Leu Ala His Cys Pro Asp Cys Gly Glu Gly His Ser 340 345
350Cys His Ser Pro Val Ala Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp
355 360 365Gly Thr Leu Lys Ile Gln Val Ser Leu Gln Ile Gly Ile Lys
Thr Asp 370 375 380Asp Ser His Asp Trp Thr Lys Leu Arg Tyr Met Asp
Asn His Met Pro385 390 395 400Ala Asp Ala Glu Arg Ala Gly Leu Phe
Val Arg Thr Ser Ala Pro Cys 405 410 415Thr Ile Thr Gly Thr Met Gly
His Phe Ile Leu Ala Arg Cys Pro Lys 420 425 430Gly Glu Thr Leu Thr
Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His 435 440 445Ser Cys Thr
His Pro Phe His His Asp Pro Pro Val Ile Gly Arg Glu 450 455 460Lys
Phe His Ser Arg Pro Gln His Gly Lys Glu Leu Pro Cys Ser Thr465 470
475 480Tyr Val Gln Ser Thr Ala Ala Thr Thr Glu Glu Ile Glu Val His
Met 485 490 495Pro Pro Asp Thr Pro Asp Arg Thr Leu Met Ser Gln Gln
Ser Gly Asn 500 505 510Val Lys Ile Thr Val Asn Gly Gln Thr Val Arg
Tyr Lys Cys Asn Cys 515 520 525Gly Gly Ser Asn Glu Gly Leu Thr Thr
Thr Asp Lys Val Ile Asn Asn 530 535 540Cys Lys Val Asp Gln Cys His
Ala Ala Val Thr Asn His Lys Lys Trp545 550 555 560Gln Tyr Asn Ser
Pro Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg 565 570 575Lys Gly
Lys Ile His Ile Pro Phe Pro Leu Ala Asn Val Thr Cys Arg 580 585
590Val Pro Lys Ala Arg Asn Pro Thr Val Thr Tyr Gly Lys Asn Gln Val
595 600 605Ile Met Leu Leu Tyr Pro Asp His Pro Thr Leu Leu Ser Tyr
Arg Asn 610 615 620Met Gly Glu Glu Pro Asn Tyr Gln Glu Glu Trp Val
Met His Lys Lys625 630 635 640Glu Val Val Leu Thr Val Pro Thr Glu
Gly Leu Glu Val Thr Trp Gly 645 650 655Asn Asn Glu Pro Tyr Lys Tyr
Trp Pro Gln Leu Ser Thr Asn Gly Thr 660 665 670Ala His Gly His Pro
His Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr 675 680 685Pro Thr Met
Thr Val Val Val Val Ser Val Ala Thr Phe Ile Leu Leu 690 695 700Ser
Met Val Gly Met Ala Ala Gly Met Cys Met Cys Ala Arg Arg Arg705 710
715 720Cys Ile Thr Pro Tyr Glu Leu Thr Pro Gly Ala Thr Val Pro Phe
Leu 725 730 735Leu Ser Leu Ile Cys Cys Ile Arg Thr Ala Lys Ala Ala
Thr Tyr Gln 740 745 750Glu Ala Ala Ile Tyr Leu Trp Asn Glu Gln Gln
Pro Leu Phe Trp Leu 755 760 765Gln Ala Leu Ile Pro Leu Ala Ala Leu
Ile Val Leu Cys Asn Cys Leu 770 775 780Arg Leu Leu Pro Cys Cys Cys
Lys Thr Leu Ala Phe Leu Ala Val Met785 790 795 800Ser Val Gly Ala
His Thr Val Ser Ala Tyr Glu His Val Thr Val Ile 805 810 815Pro Asn
Thr Val Gly Val Pro Tyr Lys Thr Leu Val Asn Arg Pro Gly 820 825
830Tyr Ser Pro Met Val Leu Glu Met Glu Leu Leu Ser Val Thr Leu Glu
835 840 845Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys Glu Tyr Lys Thr
Val Ile 850 855 860Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr Ala Glu
Cys Lys Asp Lys865 870 875 880Asn Leu Pro Asp Tyr Ser Cys Lys Val
Phe Thr Gly Val Tyr Pro Phe 885 890 895Met Trp Gly Gly Ala Tyr Cys
Phe Cys Asp Ala Glu Asn Thr Gln Leu 900 905 910Ser Glu Ala His Val
Glu Lys Ser Glu Ser Cys Lys Thr Glu Phe Ala 915 920 925Ser Ala Tyr
Arg Ala His Thr Ala Ser Ala Ser Ala Lys Leu Arg Val 930 935 940Leu
Tyr Gln Gly Asn Asn Ile Thr Val Thr Ala Tyr Ala Asn Gly Asp945 950
955 960His Ala Val Thr Val Lys Asp Ala Lys Phe Ile Val Gly Pro Met
Ser 965 970 975Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile Val Val Tyr
Lys Gly Asp 980 985 990Val Tyr Asn Met Asp Tyr Pro Pro Phe Gly Ala
Gly Arg Pro Gly Gln 995 1000 1005Phe Gly Asp Ile Gln Ser Arg Thr
Pro Glu Ser Lys Asp Val Tyr 1010 1015 1020Ala Asn Thr Gln Leu Val
Leu Gln Arg Pro Ala Val Gly Thr Val 1025 1030 1035His Val Pro Tyr
Ser Gln Ala Pro Ser Gly Phe Lys Tyr Trp Leu 1040 1045 1050Lys Glu
Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe Gly Cys 1055 1060
1065Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala Val Gly
1070 1075 1080Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe
Thr Arg 1085 1090 1095Val Val Asp Ala Pro Ser Leu Thr Asp Met Ser
Cys Glu Val Pro 1100 1105 1110Ala Cys Thr His Ser Ser Asp Phe Gly
Gly Val Ala Ile Ile Lys 1115 1120 1125Tyr Ala Ala Ser Lys Lys Gly
Lys Cys Ala Val His Ser Met Thr 1130 1135 1140Asn Ala Val Thr Ile
Arg Glu Ala Glu Ile Glu Val Glu Gly Asn 1145 1150 1155Ser Gln Leu
Gln Ile Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu 1160 1165 1170Phe
Arg Val Gln Val Cys Ser Thr Gln Val His Cys Ala Ala Glu 1175 1180
1185Cys His Pro Pro Lys Asp His Ile Val Asn Tyr Pro Ala Ser His
1190 1195 1200Thr Thr Leu Gly Val Gln Asp Ile Ser Ala Thr Ala Met
Ser Trp 1205 1210 1215Val Gln Lys Ile Thr Gly Gly Val Gly Leu Val
Val Ala Val Ala 1220 1225 1230Ala Leu Ile Leu Ile Val Val Leu Cys
Val Ser Phe Ser Arg His 1235 1240 1245302473PRTChikungunya virus
30Met Asp Pro Val Tyr Val Asp Ile Asp Ala Asp Ser Ala Phe Leu Lys1
5 10 15Ala Leu Gln Arg Ala Tyr Pro Met Phe Glu Val Glu Pro Arg Gln
Val 20 25 30Thr Pro Asn Asp His Ala Asn Ala Arg Ala Phe Ser His Leu
Ala Ile 35 40 45Lys Leu Ile Glu Gln Glu Ile Asp Pro Asp Ser Thr Ile
Leu Asp Ile 50 55 60Gly Ser Ala Pro Ala Arg Arg Met Met Ser Asp Arg
Lys Tyr His Cys65 70 75 80Val Cys Pro Met Arg Ser Ala Glu Asp Pro
Glu Arg Leu Ala Asn Tyr 85 90 95Ala Arg Lys Leu Ala Ser Ala Ala Gly
Lys Val Leu Asp Arg Asn Ile 100 105 110Ser Gly Lys Ile Gly Asp Leu
Gln Ala Val Met Ala Val Pro Asp Thr 115 120 125Glu Thr Pro Thr Phe
Cys Leu His Thr Asp Val Ser Cys Arg Gln Arg 130 135 140Ala Asp Val
Ala Ile Tyr Gln Asp Val Tyr Ala Val His Ala Pro Thr145 150 155
160Ser Leu Tyr His Gln Ala Ile Lys Gly Val Arg Val Ala Tyr Trp Val
165 170 175Gly Phe Asp Thr Thr Pro Phe Met Tyr Asn Ala Met Ala Gly
Ala Tyr 180 185 190Pro Ser Tyr Ser Thr Asn Trp Ala Asp Glu Gln Val
Leu Lys Ala Lys 195 200 205Asn Ile Gly Leu Cys Ser Thr Asp Leu Thr
Glu Gly Arg Arg Gly Lys 210 215 220Leu Ser Ile Met Arg Gly Lys Lys
Leu Lys Pro Cys Asp Arg Val Leu225 230 235 240Phe Ser Val Gly Ser
Thr Leu Tyr Pro Glu Ser Arg Lys Leu Leu Lys 245 250 255Ser Trp His
Leu Pro Ser Val Phe His Leu Lys Gly Lys Leu Ser Phe 260 265 270Thr
Cys Arg Cys Asp Thr Val Val Ser Cys Glu Gly Tyr Val Val Lys 275 280
285Arg Ile Thr Met Ser Pro Gly Leu Tyr Gly Lys Thr Thr Gly Tyr Ala
290 295 300Val Thr His His Ala Asp Gly Phe Leu Met Cys Lys Thr Thr
Asp Thr305 310 315 320Val Asp Gly Glu Arg Val Ser Phe Ser Val Cys
Thr Tyr Val Pro Ala 325 330 335Thr Ile Cys Asp Gln Met Thr Gly Ile
Leu Ala Thr Glu Val Thr Pro 340 345 350Glu Asp Ala Gln Lys Leu Leu
Val Gly Leu Asn Gln Arg Ile Val Val 355 360 365Asn Gly Arg Thr Gln
Arg Asn Thr Asn Thr Met Lys Asn Tyr Leu Leu 370 375 380Pro Val Val
Ala Gln Ala Phe Ser Lys Trp Ala Lys Glu Cys Arg Lys385 390 395
400Asp Met Glu Asp Glu Lys Leu Leu Gly Val Arg Glu Arg Thr Leu Thr
405 410 415Cys Cys Cys Leu Trp Ala Phe Lys Lys Gln Lys Thr His Thr
Val Tyr 420 425 430Lys Arg Pro Asp Thr Gln Ser Ile Gln Lys Val Gln
Ala Glu Phe Asp 435 440 445Ser Phe Val Val Pro Ser Leu Trp Ser Ser
Gly Leu Ser Ile Pro Leu 450 455 460Arg Thr Arg Ile Lys Trp Leu Leu
Ser Lys Val Pro Lys Thr Asp Leu465 470 475 480Ile Pro Tyr Ser Gly
Asp Ala Arg Glu Ala Arg Asp Ala Glu Lys Glu 485 490 495Ala Glu Glu
Glu Arg Glu Ala Glu Leu Thr Arg Glu Ala Leu Pro Pro 500 505 510Leu
Gln Ala Ala Gln Glu Asp Val Gln Val Glu Ile Asp Val Glu Gln 515 520
525Leu Glu Asp Arg Ala Gly Ala Gly Ile Ile Glu Thr Pro Arg Gly Ala
530 535 540Ile Lys Val Thr Ala Gln Pro Thr Asp His Val Val Gly Glu
Tyr Leu545 550 555 560Val Leu Ser Pro Gln Thr Val Leu Arg Ser Gln
Lys Leu Ser Leu Ile 565 570 575His Ala Leu Ala Glu Gln Val Lys Thr
Cys Thr His Asn Gly Arg Ala 580 585 590Gly Arg Tyr Ala Val Glu Ala
Tyr Asp Gly Arg Val Leu Val Pro Ser 595 600 605Gly Tyr Ala Ile Ser
Pro Glu Asp Phe Gln Ser Leu Ser Glu Ser Ala 610 615 620Thr Met Val
Tyr Asn Glu Arg Glu Phe Val Asn Arg Lys Leu His His625 630 635
640Ile Ala Met His Gly Pro Ala Leu Asn Thr Asp Glu Glu Ser Tyr Glu
645 650 655Leu Val Arg Ala Glu Arg Thr Glu His Glu Tyr Val Tyr Asp
Val Asp 660 665 670Gln Arg Arg Cys Cys Lys Lys Glu Glu Ala Ala Gly
Leu Val Leu Val 675 680 685Gly Asp Leu Thr Asn Pro Pro Tyr His Glu
Phe Ala Tyr Glu Gly Leu 690 695 700Lys Ile Arg Pro Ala Cys Pro Tyr
Lys Ile Ala Val Ile Gly Val Phe705 710 715 720Gly Val Pro Gly Ser
Gly Lys Ser Ala Ile Ile Lys Asn Leu Val Thr 725 730 735Arg Gln Asp
Leu Val Thr Ser Gly Lys Lys Glu Asn Cys Gln Glu Ile 740 745 750Thr
Thr Asp Val Met Arg Gln Arg Gly Leu Glu Ile Ser Ala Arg Thr 755 760
765Val Asp Ser Leu Leu Leu Asn Gly Cys Asn Arg Pro Val Asp Val Leu
770 775 780Tyr Val Asp Glu Ala Phe Ala Cys His Ser Gly Thr Leu Leu
Ala Leu785 790 795 800Ile Ala Leu Val Arg Pro Arg Gln Lys Val Val
Leu Cys Gly Asp Pro 805 810 815Lys Gln Cys Gly Phe Phe Asn Met Met
Gln Met Lys Val Asn Tyr Asn 820 825 830His Asn Ile Cys Thr Gln Val
Tyr His Lys Ser Ile Ser Arg Arg Cys 835 840 845Thr Leu Pro Val Thr
Ala Ile Val Ser Ser Leu His Tyr Glu Gly Lys 850 855 860Met Arg Thr
Thr Asn Glu Tyr Asn Lys Pro Ile Val Val Asp Thr Thr865 870 875
880Gly Ser Thr Lys Pro Asp Pro Gly Asp Leu Val Leu Thr Cys Phe Arg
885 890 895Gly Trp Val Lys Gln Leu Gln Ile Asp Tyr Arg Gly Tyr Glu
Val Met 900 905 910Thr Ala Ala Ala Ser Gln Gly Leu Thr Arg Lys Gly
Val Tyr Ala Val 915 920 925Arg Gln Lys Val Asn Glu Asn Pro Leu Tyr
Ala Ser Thr Ser Glu His 930 935 940Val Asn Val Leu Leu Thr Arg Thr
Glu Gly Lys Leu Val Trp Lys Thr945 950 955 960Leu Ser Gly Asp Pro
Trp Ile Lys Thr Leu Gln Asn Pro Pro Lys Gly 965 970 975Asn Phe Lys
Ala Thr Ile Lys Glu Trp Glu Val Glu His Ala Ser Ile 980 985 990Met
Ala Gly Ile Cys Ser His Gln Met Thr Phe Asp Thr Phe Gln Asn 995
1000 1005Lys Ala Asn Val Cys Trp Ala Lys Ser Leu Val Pro Ile Leu
Glu 1010 1015 1020Thr Ala Gly Ile Lys Leu Asn Asp Arg Gln Trp Ser
Gln Ile Ile 1025 1030 1035Gln Ala Phe Lys Glu Asp Lys Ala Tyr Ser
Pro Glu Val Ala Leu 1040 1045 1050Asn Glu Ile Cys Thr Arg Met Tyr
Gly Val Asp Leu Asp Ser Gly 1055 1060 1065Leu Phe Ser Lys Pro Leu
Val Ser Val Tyr Tyr Ala Asp Asn His 1070 1075 1080Trp Asp Asn Arg
Pro Gly Gly Lys Met Phe Gly Phe Asn Pro Glu 1085 1090 1095Ala Ala
Ser Ile Leu Glu Arg Lys Tyr Pro Phe Thr Lys Gly Lys 1100 1105
1110Trp Asn Ile Asn Lys Gln Ile Cys Val Thr Thr Arg Arg Ile Glu
1115 1120
1125Asp Phe Asn Pro Thr Thr Asn Ile Ile Pro Ala Asn Arg Arg Leu
1130 1135 1140Pro His Ser Leu Val Ala Glu His Arg Pro Val Lys Gly
Glu Arg 1145 1150 1155Met Glu Trp Leu Val Asn Lys Ile Asn Gly His
His Val Leu Leu 1160 1165 1170Val Ser Gly Tyr Asn Leu Ala Leu Pro
Thr Lys Arg Val Thr Trp 1175 1180 1185Val Ala Pro Leu Gly Val Arg
Gly Ala Asp Tyr Thr Tyr Asn Leu 1190 1195 1200Glu Leu Gly Leu Pro
Ala Thr Leu Gly Arg Tyr Asp Leu Val Val 1205 1210 1215Ile Asn Ile
His Thr Pro Phe Arg Ile His His Tyr Gln Gln Cys 1220 1225 1230Val
Asp His Ala Met Lys Leu Gln Met Leu Gly Gly Asp Ser Leu 1235 1240
1245Arg Leu Leu Lys Pro Gly Gly Ser Leu Leu Ile Arg Ala Tyr Gly
1250 1255 1260Tyr Ala Asp Arg Thr Ser Glu Arg Val Ile Cys Val Leu
Gly Arg 1265 1270 1275Lys Phe Arg Ser Ser Arg Ala Leu Lys Pro Pro
Cys Val Thr Ser 1280 1285 1290Asn Thr Glu Met Phe Phe Leu Phe Ser
Asn Phe Asp Asn Gly Arg 1295 1300 1305Arg Asn Phe Thr Thr His Val
Met Asn Asn Gln Leu Asn Ala Ala 1310 1315 1320Phe Val Gly Gln Val
Thr Arg Ala Gly Cys Ala Pro Ser Tyr Arg 1325 1330 1335Val Lys Arg
Met Asp Ile Ala Lys Asn Asp Glu Glu Cys Val Val 1340 1345 1350Asn
Ala Ala Asn Pro Arg Gly Leu Pro Gly Asp Gly Val Cys Lys 1355 1360
1365Ala Val Tyr Lys Lys Trp Pro Glu Ser Phe Lys Asn Ser Ala Thr
1370 1375 1380Pro Val Gly Thr Ala Lys Thr Val Met Cys Gly Thr Tyr
Pro Val 1385 1390 1395Ile His Ala Val Gly Pro Asn Phe Ser Asn Tyr
Ser Glu Ser Glu 1400 1405 1410Gly Asp Arg Glu Leu Ala Ala Ala Tyr
Arg Glu Val Ala Lys Glu 1415 1420 1425Val Thr Arg Leu Gly Val Asn
Ser Val Ala Ile Pro Leu Leu Ser 1430 1435 1440Thr Gly Val Tyr Ser
Gly Gly Lys Asp Arg Leu Thr Gln Ser Leu 1445 1450 1455Asn His Leu
Phe Thr Ala Met Asp Ser Thr Asp Ala Asp Val Val 1460 1465 1470Ile
Tyr Cys Arg Asp Lys Glu Trp Glu Lys Lys Ile Ser Glu Ala 1475 1480
1485Ile Gln Met Arg Thr Gln Val Glu Leu Leu Asp Glu His Ile Ser
1490 1495 1500Ile Asp Cys Asp Ile Val Arg Val His Pro Asp Ser Ser
Leu Ala 1505 1510 1515Gly Arg Lys Gly Tyr Ser Thr Thr Glu Gly Ala
Leu Tyr Ser Tyr 1520 1525 1530Leu Glu Gly Thr Arg Phe His Gln Thr
Ala Val Asp Met Ala Glu 1535 1540 1545Ile His Thr Met Trp Pro Lys
Gln Thr Glu Ala Asn Glu Gln Val 1550 1555 1560Cys Leu Tyr Ala Leu
Gly Glu Ser Ile Glu Ser Ile Arg Gln Lys 1565 1570 1575Cys Pro Val
Asp Asp Ala Asp Ala Ser Ser Pro Pro Lys Thr Val 1580 1585 1590Pro
Cys Leu Cys Arg Tyr Ala Met Thr Pro Glu Arg Val Thr Arg 1595 1600
1605Leu Arg Met Asn His Val Thr Ser Ile Ile Val Cys Ser Ser Phe
1610 1615 1620Pro Leu Pro Lys Tyr Lys Ile Glu Gly Val Gln Lys Val
Lys Cys 1625 1630 1635Ser Lys Val Met Leu Phe Asp His Asn Val Pro
Ser Arg Val Ser 1640 1645 1650Pro Arg Glu Tyr Arg Ser Ser Gln Glu
Ser Ala Gln Glu Ala Ser 1655 1660 1665Thr Ile Thr Ser Leu Thr His
Ser Gln Phe Asp Leu Ser Val Asp 1670 1675 1680Gly Glu Ile Leu Pro
Val Pro Ser Asp Leu Asp Ala Asp Ala Pro 1685 1690 1695Ala Leu Glu
Pro Ala Leu Asp Asp Gly Ala Thr His Thr Leu Pro 1700 1705 1710Ser
Thr Thr Gly Asn Leu Ala Ala Val Ser Asp Trp Val Met Ser 1715 1720
1725Thr Val Pro Val Ala Pro Pro Arg Arg Arg Arg Gly Arg Asn Leu
1730 1735 1740Thr Val Thr Cys Asp Glu Arg Glu Gly Asn Ile Thr Pro
Met Ala 1745 1750 1755Ser Val Arg Phe Phe Arg Ala Glu Leu Cys Pro
Val Val Gln Glu 1760 1765 1770Thr Ala Glu Thr Arg Asp Thr Ala Met
Ser Leu Gln Ala Pro Pro 1775 1780 1785Ser Thr Ala Thr Glu Pro Asn
His Pro Pro Ile Ser Phe Gly Ala 1790 1795 1800Ser Ser Glu Thr Phe
Pro Ile Thr Phe Gly Asp Phe Asn Glu Gly 1805 1810 1815Glu Ile Glu
Ser Leu Ser Ser Glu Leu Leu Thr Phe Gly Asp Phe 1820 1825 1830Leu
Pro Gly Glu Val Asp Asp Leu Thr Asp Ser Asp Trp Ser Thr 1835 1840
1845Cys Ser Asp Thr Asp Asp Glu Leu Leu Asp Arg Ala Gly Gly Tyr
1850 1855 1860Ile Phe Ser Ser Asp Thr Gly Pro Gly His Leu Gln Gln
Lys Ser 1865 1870 1875Val Arg Gln Ser Val Leu Pro Val Asn Thr Leu
Glu Glu Val His 1880 1885 1890Glu Glu Lys Cys Tyr Pro Pro Lys Leu
Asp Glu Ala Lys Glu Gln 1895 1900 1905Leu Leu Leu Lys Lys Leu Gln
Glu Ser Ala Ser Met Ala Asn Arg 1910 1915 1920Ser Arg Tyr Gln Ser
Arg Lys Val Glu Asn Met Lys Ala Ala Ile 1925 1930 1935Ile Gln Arg
Leu Lys Arg Gly Cys Arg Leu Tyr Leu Met Ser Glu 1940 1945 1950Thr
Pro Lys Val Pro Thr Tyr Arg Thr Thr Tyr Pro Ala Pro Val 1955 1960
1965Tyr Ser Pro Pro Ile Asn Val Arg Leu Ser Asn Pro Glu Ser Ala
1970 1975 1980Val Ala Ala Cys Asn Glu Phe Leu Ala Arg Asn Tyr Pro
Thr Val 1985 1990 1995Ser Ser Tyr Gln Ile Thr Asp Glu Tyr Asp Ala
Tyr Leu Asp Met 2000 2005 2010Val Asp Gly Ser Glu Ser Cys Leu Asp
Arg Ala Thr Phe Asn Pro 2015 2020 2025Ser Lys Leu Arg Ser Tyr Pro
Lys Gln His Ala Tyr His Ala Pro 2030 2035 2040Ser Ile Arg Ser Ala
Val Pro Ser Pro Phe Gln Asn Thr Leu Gln 2045 2050 2055Asn Val Leu
Ala Ala Ala Thr Lys Arg Asn Cys Asn Val Thr Gln 2060 2065 2070Met
Arg Glu Leu Pro Thr Leu Asp Ser Ala Val Phe Asn Val Glu 2075 2080
2085Cys Phe Lys Lys Phe Ala Cys Asn Gln Glu Tyr Trp Glu Glu Phe
2090 2095 2100Ala Ala Ser Pro Ile Arg Ile Thr Thr Glu Asn Leu Ala
Thr Tyr 2105 2110 2115Val Thr Lys Leu Lys Gly Pro Lys Ala Ala Ala
Leu Phe Ala Lys 2120 2125 2130Thr His Asn Leu Leu Pro Leu Gln Glu
Val Pro Met Asp Arg Phe 2135 2140 2145Thr Val Asp Met Lys Arg Asp
Val Lys Val Thr Pro Gly Thr Lys 2150 2155 2160His Thr Glu Glu Arg
Pro Lys Val Gln Val Ile Gln Ala Ala Glu 2165 2170 2175Pro Leu Ala
Thr Ala Tyr Leu Cys Gly Ile His Arg Glu Leu Val 2180 2185 2190Arg
Arg Leu Asn Ala Val Leu Leu Pro Asn Val His Thr Leu Phe 2195 2200
2205Asp Met Ser Ala Glu Asp Phe Asp Ala Ile Ile Ala Ala His Phe
2210 2215 2220Lys Pro Gly Asp Thr Val Leu Glu Thr Asp Ile Ala Ser
Phe Asp 2225 2230 2235Lys Ser Gln Asp Asp Ser Leu Ala Leu Thr Ala
Leu Met Leu Leu 2240 2245 2250Glu Asp Leu Gly Val Asp His Ser Leu
Leu Asp Leu Ile Glu Ala 2255 2260 2265Ala Phe Gly Glu Ile Ser Ser
Cys His Leu Pro Thr Gly Thr Arg 2270 2275 2280Phe Lys Phe Gly Ala
Met Met Lys Ser Gly Met Phe Leu Thr Leu 2285 2290 2295Phe Val Asn
Thr Leu Leu Asn Ile Thr Ile Ala Ser Arg Val Leu 2300 2305 2310Glu
Asp Arg Leu Thr Lys Ser Ala Cys Ala Ala Phe Ile Gly Asp 2315 2320
2325Asp Asn Ile Ile His Gly Val Val Ser Asp Glu Leu Met Ala Ala
2330 2335 2340Arg Cys Ala Thr Trp Met Asn Met Glu Val Lys Ile Ile
Asp Ala 2345 2350 2355Val Val Ser Leu Lys Ala Pro Tyr Phe Cys Gly
Gly Phe Ile Leu 2360 2365 2370His Asp Thr Val Thr Gly Thr Ala Cys
Arg Val Ala Asp Pro Leu 2375 2380 2385Lys Arg Leu Phe Lys Leu Gly
Lys Pro Leu Ala Ala Gly Asp Glu 2390 2395 2400Gln Asp Glu Asp Arg
Arg Arg Ala Leu Ala Asp Glu Val Ile Arg 2405 2410 2415Trp Gln Arg
Thr Gly Leu Ile Asp Glu Leu Glu Lys Ala Val Tyr 2420 2425 2430Ser
Arg Tyr Glu Val Gln Gly Ile Ser Val Val Val Met Ser Met 2435 2440
2445Ala Thr Phe Ala Ser Ser Arg Ser Asn Phe Glu Lys Leu Arg Gly
2450 2455 2460Pro Val Ile Thr Leu Tyr Gly Gly Pro Lys 2465
2470312473PRTChikungunya virus 31Met Asp Pro Val Tyr Val Asp Ile
Asp Ala Asp Ser Ala Phe Leu Lys1 5 10 15Ala Leu Gln Arg Ala Tyr Pro
Met Phe Glu Val Glu Pro Arg Gln Val 20 25 30Thr Pro Asn Asp His Ala
Asn Ala Arg Ala Phe Ser His Leu Ala Ile 35 40 45Lys Leu Ile Glu Gln
Glu Ile Asp Pro Asp Ser Thr Ile Leu Asp Ile 50 55 60Gly Ser Ala Pro
Ala Arg Arg Met Met Ser Asp Arg Lys Tyr His Cys65 70 75 80Val Cys
Pro Met Arg Ser Ala Glu Asp Pro Glu Arg Leu Ala Asn Tyr 85 90 95Ala
Arg Lys Leu Ala Ser Ala Ala Gly Lys Val Leu Asp Arg Asn Ile 100 105
110Ser Gly Lys Ile Gly Asp Leu Gln Ala Val Met Ala Val Pro Asp Thr
115 120 125Glu Thr Pro Thr Phe Cys Leu His Thr Asp Val Ser Cys Arg
Gln Arg 130 135 140Ala Asp Val Ala Ile Tyr Gln Asp Val Tyr Ala Val
His Ala Pro Thr145 150 155 160Ser Leu Tyr His Gln Ala Ile Lys Gly
Val Arg Val Ala Tyr Trp Val 165 170 175Gly Phe Asp Thr Thr Pro Phe
Met Tyr Asn Ala Met Ala Gly Ala Tyr 180 185 190Pro Ser Tyr Ser Thr
Asn Trp Ala Asp Glu Gln Val Leu Lys Ala Lys 195 200 205Asn Ile Gly
Leu Cys Ser Thr Asp Leu Thr Glu Gly Arg Arg Gly Lys 210 215 220Leu
Ser Ile Met Arg Gly Lys Lys Leu Lys Pro Cys Asp Arg Val Leu225 230
235 240Phe Ser Val Gly Ser Thr Leu Tyr Pro Glu Ser Arg Lys Leu Leu
Lys 245 250 255Ser Trp His Leu Pro Ser Val Phe His Leu Lys Gly Lys
Leu Ser Phe 260 265 270Thr Cys Arg Cys Asp Thr Val Val Ser Cys Glu
Gly Tyr Val Val Lys 275 280 285Arg Ile Thr Met Ser Pro Gly Leu Tyr
Gly Lys Thr Thr Gly Tyr Ala 290 295 300Val Thr His His Ala Asp Gly
Phe Leu Met Cys Lys Thr Thr Asp Thr305 310 315 320Val Asp Gly Glu
Arg Val Ser Phe Ser Val Cys Thr Tyr Val Pro Ala 325 330 335Thr Ile
Cys Asp Gln Met Thr Gly Ile Leu Ala Thr Glu Val Thr Pro 340 345
350Glu Asp Ala Gln Lys Leu Leu Val Gly Leu Asn Gln Arg Ile Val Val
355 360 365Asn Gly Arg Thr Gln Arg Asn Thr Asn Thr Met Lys Asn Tyr
Leu Leu 370 375 380Pro Val Val Ala Gln Ala Phe Ser Lys Trp Ala Lys
Glu Cys Arg Lys385 390 395 400Asp Met Glu Asp Glu Lys Leu Leu Gly
Val Arg Glu Arg Thr Leu Thr 405 410 415Cys Cys Cys Leu Trp Ala Phe
Lys Lys Gln Lys Thr His Thr Val Tyr 420 425 430Lys Arg Pro Asp Thr
Gln Ser Ile Gln Lys Val Gln Ala Glu Phe Asp 435 440 445Ser Phe Val
Val Pro Ser Leu Trp Ser Ser Gly Leu Ser Ile Pro Leu 450 455 460Arg
Thr Arg Ile Lys Trp Leu Leu Ser Lys Val Pro Lys Thr Asp Leu465 470
475 480Ile Pro Tyr Ser Gly Asp Ala Arg Glu Ala Arg Asp Ala Glu Lys
Glu 485 490 495Ala Glu Glu Glu Arg Glu Ala Glu Leu Thr Arg Glu Ala
Leu Pro Pro 500 505 510Leu Gln Ala Ala Gln Glu Asp Val Gln Val Glu
Ile Asp Val Glu Gln 515 520 525Leu Glu Asp Arg Ala Gly Ala Gly Ile
Ile Glu Thr Pro Arg Gly Ala 530 535 540Ile Lys Val Thr Ala Gln Pro
Thr Asp His Val Val Gly Glu Tyr Leu545 550 555 560Val Leu Ser Pro
Gln Thr Val Leu Arg Ser Gln Lys Leu Ser Leu Ile 565 570 575His Ala
Leu Ala Glu Gln Val Lys Thr Cys Thr His Asn Gly Arg Ala 580 585
590Gly Arg Tyr Ala Val Glu Ala Tyr Asp Gly Arg Val Leu Val Pro Ser
595 600 605Gly Tyr Ala Ile Ser Pro Glu Asp Phe Gln Ser Leu Ser Glu
Ser Ala 610 615 620Thr Met Val Tyr Asn Glu Arg Glu Phe Val Asn Arg
Lys Leu His His625 630 635 640Ile Ala Met His Gly Pro Ala Leu Asn
Thr Asp Glu Glu Ser Tyr Glu 645 650 655Leu Val Arg Ala Glu Arg Thr
Glu His Glu Tyr Val Tyr Asp Val Asp 660 665 670Gln Arg Arg Cys Cys
Lys Lys Glu Glu Ala Ala Gly Leu Val Leu Val 675 680 685Gly Asp Leu
Thr Asn Pro Pro Tyr His Glu Phe Ala Tyr Glu Gly Leu 690 695 700Lys
Ile Arg Pro Ala Cys Pro Tyr Lys Ile Ala Val Ile Gly Val Phe705 710
715 720Gly Val Pro Gly Ser Gly Lys Ser Ala Ile Ile Lys Asn Leu Val
Thr 725 730 735Arg Gln Asp Leu Val Thr Ser Gly Lys Lys Glu Asn Cys
Gln Glu Ile 740 745 750Thr Thr Asp Val Met Arg Gln Arg Gly Leu Glu
Ile Ser Ala Arg Thr 755 760 765Val Asp Ser Leu Leu Leu Asn Gly Cys
Asn Arg Pro Val Asp Val Leu 770 775 780Tyr Val Asp Glu Ala Phe Ala
Cys His Ser Gly Thr Leu Leu Ala Leu785 790 795 800Ile Ala Leu Val
Arg Pro Arg Gln Lys Val Val Leu Cys Gly Asp Pro 805 810 815Lys Gln
Cys Gly Phe Phe Asn Met Met Gln Met Lys Val Asn Tyr Asn 820 825
830His Asn Ile Cys Thr Gln Val Tyr His Lys Ser Ile Ser Arg Arg Cys
835 840 845Thr Leu Pro Val Thr Ala Ile Val Ser Ser Leu His Tyr Glu
Gly Lys 850 855 860Met Arg Thr Thr Asn Glu Tyr Asn Lys Pro Ile Val
Val Asp Thr Thr865 870 875 880Gly Ser Thr Lys Pro Asp Pro Gly Asp
Leu Val Leu Thr Cys Phe Arg 885 890 895Gly Trp Val Lys Gln Leu Gln
Ile Asp Tyr Arg Gly Tyr Glu Val Met 900 905 910Thr Ala Ala Ala Ser
Gln Gly Leu Thr Arg Lys Gly Val Tyr Ala Val 915 920 925Arg Gln Lys
Val Asn Glu Asn Pro Leu Tyr Ala Ser Thr Ser Glu His 930 935 940Val
Asn Val Leu Leu Thr Arg Thr Glu Gly Lys Leu Val Trp Lys Thr945 950
955 960Leu Ser Gly Asp Pro Trp Ile Lys Thr Leu Gln Asn Pro Pro Lys
Gly 965 970 975Asn Phe Lys Ala Thr Ile Lys Glu Trp Glu Val Glu His
Ala Ser Ile 980 985 990Met Ala Gly Ile Cys Ser His Gln Met Thr Phe
Asp Thr Phe Gln Asn 995 1000 1005Lys Ala Asn Val Cys Trp Ala Lys
Ser Leu Val Pro Ile Leu Glu 1010 1015 1020Thr Ala Gly Ile Lys Leu
Asn Asp Arg Gln Trp Ser Gln Ile Ile 1025 1030 1035Gln Ala Phe Lys
Glu Asp Lys Ala Tyr Ser Pro Glu Val Ala Leu 1040 1045 1050Asn Glu
Ile Cys Thr Arg Met Tyr Gly Val Asp Leu Asp Ser Gly 1055 1060
1065Leu Phe Ser Lys Pro Leu Val Ser Val Tyr Tyr Ala Asp Asn His
1070 1075 1080Trp Asp Asn Arg Pro Gly Gly Lys Met Phe Gly Phe Asn
Pro Glu 1085 1090 1095Ala Ala Ser Ile
Leu Glu Arg Lys Tyr Pro Phe Thr Lys Gly Lys 1100 1105 1110Trp Asn
Ile Asn Lys Gln Ile Cys Val Thr Thr Arg Arg Ile Glu 1115 1120
1125Asp Phe Asn Pro Thr Thr Asn Ile Ile Pro Ala Asn Arg Arg Leu
1130 1135 1140Pro His Ser Leu Val Ala Glu His Arg Pro Val Lys Gly
Glu Arg 1145 1150 1155Met Glu Trp Leu Val Asn Lys Ile Asn Gly His
His Val Leu Leu 1160 1165 1170Val Ser Gly Tyr Asn Leu Ala Leu Pro
Thr Lys Arg Val Thr Trp 1175 1180 1185Val Ala Pro Leu Gly Val Arg
Gly Ala Asp Tyr Thr Tyr Asn Leu 1190 1195 1200Glu Leu Gly Leu Pro
Ala Thr Leu Gly Arg Tyr Asp Leu Val Val 1205 1210 1215Ile Asn Ile
His Thr Pro Phe Arg Ile His His Tyr Gln Gln Cys 1220 1225 1230Val
Asp His Ala Met Lys Leu Gln Met Leu Gly Gly Asp Ser Leu 1235 1240
1245Arg Leu Leu Lys Pro Gly Gly Ser Leu Leu Ile Arg Ala Tyr Gly
1250 1255 1260Tyr Ala Asp Arg Thr Ser Glu Arg Val Ile Cys Val Leu
Gly Arg 1265 1270 1275Lys Phe Arg Ser Ser Arg Ala Leu Lys Pro Pro
Cys Val Thr Ser 1280 1285 1290Asn Thr Glu Met Phe Phe Leu Phe Ser
Asn Phe Asp Asn Gly Arg 1295 1300 1305Arg Asn Phe Thr Thr His Val
Met Asn Asn Gln Leu Asn Ala Ala 1310 1315 1320Phe Val Gly Gln Val
Thr Arg Ala Gly Cys Ala Pro Ser Tyr Arg 1325 1330 1335Val Lys Arg
Met Asp Ile Ala Lys Asn Asp Glu Glu Cys Val Val 1340 1345 1350Asn
Ala Ala Asn Pro Arg Gly Leu Pro Gly Asp Gly Val Cys Lys 1355 1360
1365Ala Val Tyr Lys Lys Trp Pro Glu Ser Phe Lys Asn Ser Ala Thr
1370 1375 1380Pro Val Gly Thr Ala Lys Thr Val Met Cys Gly Thr Tyr
Pro Val 1385 1390 1395Ile His Ala Val Gly Pro Asn Phe Ser Asn Tyr
Ser Glu Ser Glu 1400 1405 1410Gly Asp Arg Glu Leu Ala Ala Ala Tyr
Arg Glu Val Ala Lys Glu 1415 1420 1425Val Thr Arg Leu Gly Val Asn
Ser Val Ala Ile Pro Leu Leu Ser 1430 1435 1440Thr Gly Val Tyr Ser
Gly Gly Lys Asp Arg Leu Thr Gln Ser Leu 1445 1450 1455Asn His Leu
Phe Thr Ala Met Asp Ser Thr Asp Ala Asp Val Val 1460 1465 1470Ile
Tyr Cys Arg Asp Lys Glu Trp Glu Lys Lys Ile Ser Glu Ala 1475 1480
1485Ile Gln Met Arg Thr Gln Val Glu Leu Leu Asp Glu His Ile Ser
1490 1495 1500Ile Asp Cys Asp Ile Val Arg Val His Pro Asp Ser Ser
Leu Ala 1505 1510 1515Gly Arg Lys Gly Tyr Ser Thr Thr Glu Gly Ala
Leu Tyr Ser Tyr 1520 1525 1530Leu Glu Gly Thr Arg Phe His Gln Thr
Ala Val Asp Met Ala Glu 1535 1540 1545Ile His Thr Met Trp Pro Lys
Gln Thr Glu Ala Asn Glu Gln Val 1550 1555 1560Cys Leu Tyr Ala Leu
Gly Glu Ser Ile Glu Ser Ile Arg Gln Lys 1565 1570 1575Cys Pro Val
Asp Asp Ala Asp Ala Ser Ser Pro Pro Lys Thr Val 1580 1585 1590Pro
Cys Leu Cys Arg Tyr Ala Met Thr Pro Glu Arg Val Thr Arg 1595 1600
1605Leu Arg Met Asn His Val Thr Ser Ile Ile Val Cys Ser Ser Phe
1610 1615 1620Pro Leu Pro Lys Tyr Lys Ile Glu Gly Val Gln Lys Val
Lys Cys 1625 1630 1635Ser Lys Val Met Leu Phe Asp His Asn Val Pro
Ser Arg Val Ser 1640 1645 1650Pro Arg Glu Tyr Arg Ser Ser Gln Glu
Ser Ala Gln Glu Ala Ser 1655 1660 1665Thr Ile Thr Ser Leu Thr His
Ser Gln Phe Asp Leu Ser Val Asp 1670 1675 1680Gly Glu Ile Leu Pro
Val Pro Pro Asp Leu Asp Ala Asp Ala Pro 1685 1690 1695Ala Leu Glu
Pro Ala Leu Asp Asp Gly Ala Thr His Thr Leu Pro 1700 1705 1710Ser
Thr Thr Gly Asn Leu Ala Ala Val Ser Asp Trp Val Met Ser 1715 1720
1725Thr Val Pro Val Ala Pro Pro Arg Arg Arg Arg Gly Arg Asn Leu
1730 1735 1740Thr Val Thr Cys Asp Glu Arg Glu Gly Asn Ile Thr Pro
Met Ala 1745 1750 1755Ser Val Arg Phe Phe Arg Ala Glu Leu Cys Pro
Val Val Gln Glu 1760 1765 1770Thr Ala Glu Thr Arg Asp Thr Ala Met
Ser Leu Gln Ala Pro Pro 1775 1780 1785Ser Thr Ala Thr Glu Pro Asn
His Pro Pro Ile Ser Phe Gly Ala 1790 1795 1800Ser Ser Glu Thr Phe
Pro Ile Thr Phe Gly Asp Phe Asn Glu Gly 1805 1810 1815Glu Ile Glu
Ser Leu Ser Ser Glu Leu Leu Thr Phe Gly Asp Phe 1820 1825 1830Leu
Pro Gly Glu Val Asp Asp Leu Thr Asp Ser Asp Trp Ser Thr 1835 1840
1845Cys Ser Asp Thr Asp Asp Glu Leu Leu Asp Arg Ala Gly Gly Tyr
1850 1855 1860Ile Phe Ser Ser Asp Thr Gly Pro Gly His Leu Gln Gln
Lys Ser 1865 1870 1875Val Arg Gln Ser Val Leu Pro Val Asn Thr Leu
Glu Glu Val His 1880 1885 1890Glu Glu Lys Cys Tyr Pro Pro Lys Leu
Asp Glu Ala Lys Glu Gln 1895 1900 1905Leu Leu Leu Lys Lys Leu Gln
Glu Ser Ala Ser Met Ala Asn Arg 1910 1915 1920Ser Arg Tyr Gln Ser
Arg Lys Val Glu Asn Met Lys Ala Ala Ile 1925 1930 1935Ile Gln Arg
Leu Lys Arg Gly Cys Arg Leu Tyr Leu Met Ser Glu 1940 1945 1950Thr
Pro Lys Val Pro Thr Tyr Arg Thr Thr Tyr Pro Ala Pro Val 1955 1960
1965Tyr Ser Pro Pro Ile Asn Val Arg Leu Ser Asn Pro Glu Ser Ala
1970 1975 1980Val Ala Ala Cys Asn Glu Phe Leu Ala Arg Asn Tyr Pro
Thr Val 1985 1990 1995Ser Ser Tyr Gln Ile Thr Asp Glu Tyr Asp Ala
Tyr Leu Asp Met 2000 2005 2010Val Asp Gly Ser Glu Ser Cys Leu Asp
Arg Ala Thr Phe Asn Pro 2015 2020 2025Ser Lys Leu Arg Ser Tyr Pro
Lys Gln His Ala Tyr His Ala Pro 2030 2035 2040Ser Ile Arg Ser Ala
Val Pro Ser Pro Phe Gln Asn Thr Leu Gln 2045 2050 2055Asn Val Leu
Ala Ala Ala Thr Lys Arg Asn Cys Asn Val Thr Gln 2060 2065 2070Met
Arg Glu Leu Pro Thr Leu Asp Ser Ala Val Phe Asn Val Glu 2075 2080
2085Cys Phe Lys Lys Phe Ala Cys Asn Gln Glu Tyr Trp Glu Glu Phe
2090 2095 2100Ala Ala Ser Pro Ile Arg Ile Thr Thr Glu Asn Leu Ala
Thr Tyr 2105 2110 2115Val Thr Lys Leu Lys Gly Pro Lys Ala Ala Ala
Leu Phe Ala Lys 2120 2125 2130Thr His Asn Leu Leu Pro Leu Gln Glu
Val Pro Met Asp Arg Phe 2135 2140 2145Thr Val Asp Met Lys Arg Asp
Val Lys Val Thr Pro Gly Thr Lys 2150 2155 2160His Thr Glu Glu Arg
Pro Lys Val Gln Val Ile Gln Ala Ala Glu 2165 2170 2175Pro Leu Ala
Thr Ala Tyr Leu Cys Gly Ile His Arg Glu Leu Val 2180 2185 2190Arg
Arg Leu Asn Ala Val Leu Leu Pro Asn Val His Thr Leu Phe 2195 2200
2205Asp Met Ser Ala Glu Asp Phe Asp Ala Ile Ile Ala Ala His Phe
2210 2215 2220Lys Pro Gly Asp Thr Val Leu Glu Thr Asp Ile Ala Ser
Phe Asp 2225 2230 2235Lys Ser Gln Asp Asp Ser Leu Ala Leu Thr Ala
Leu Met Leu Leu 2240 2245 2250Glu Asp Leu Gly Val Asp His Ser Leu
Leu Asp Leu Ile Glu Ala 2255 2260 2265Ala Phe Gly Glu Ile Ser Ser
Cys His Leu Pro Thr Gly Thr Arg 2270 2275 2280Phe Lys Phe Gly Ala
Met Met Lys Ser Gly Met Phe Leu Thr Leu 2285 2290 2295Phe Val Asn
Thr Leu Leu Asn Ile Thr Ile Ala Ser Arg Val Leu 2300 2305 2310Glu
Asp Arg Leu Thr Lys Ser Ala Cys Ala Ala Phe Ile Gly Asp 2315 2320
2325Asp Asn Ile Ile His Gly Val Val Ser Asp Glu Leu Met Ala Ala
2330 2335 2340Arg Cys Ala Thr Trp Met Asn Met Glu Val Lys Ile Ile
Asp Ala 2345 2350 2355Val Val Ser Leu Lys Ala Pro Tyr Phe Cys Gly
Gly Phe Ile Leu 2360 2365 2370His Asp Thr Val Thr Gly Thr Ala Cys
Arg Val Ala Asp Pro Leu 2375 2380 2385Lys Arg Leu Phe Lys Leu Gly
Lys Pro Leu Ala Ala Gly Asp Glu 2390 2395 2400Gln Asp Glu Asp Arg
Arg Arg Ala Leu Ala Asp Glu Val Ile Arg 2405 2410 2415Trp Gln Arg
Thr Gly Leu Ile Asp Glu Leu Glu Lys Ala Val Tyr 2420 2425 2430Ser
Arg Tyr Glu Val Gln Gly Ile Ser Val Val Val Met Ser Met 2435 2440
2445Ala Thr Phe Ala Ser Ser Arg Ser Asn Phe Glu Lys Leu Arg Gly
2450 2455 2460Pro Val Ile Thr Leu Tyr Gly Gly Pro Lys 2465
2470322473PRTChikungunya virus 32Met Asp Pro Val Tyr Val Asp Ile
Asp Ala Asp Ser Ala Phe Leu Lys1 5 10 15Ala Leu Gln Arg Ala Tyr Pro
Met Phe Glu Val Glu Pro Arg Gln Val 20 25 30Thr Pro Asn Asp His Ala
Asn Ala Arg Ala Phe Ser His Leu Ala Ile 35 40 45Lys Leu Ile Glu Gln
Glu Ile Asp Pro Asp Ser Thr Ile Leu Asp Ile 50 55 60Gly Ser Ala Pro
Ala Arg Arg Met Met Ser Asp Arg Lys Tyr His Cys65 70 75 80Val Cys
Pro Met Arg Ser Ala Glu Asp Pro Glu Arg Leu Ala Asn Tyr 85 90 95Ala
Arg Lys Leu Ala Ser Ala Ala Gly Lys Val Leu Asp Arg Asn Ile 100 105
110Ser Gly Lys Ile Gly Asp Leu Gln Ala Val Met Ala Val Pro Asp Thr
115 120 125Glu Thr Pro Thr Phe Cys Leu His Thr Asp Val Ser Cys Arg
Gln Arg 130 135 140Ala Asp Val Ala Ile Tyr Gln Asp Val Tyr Ala Val
His Ala Pro Thr145 150 155 160Ser Leu Tyr His Gln Ala Ile Lys Gly
Val Arg Val Ala Tyr Trp Val 165 170 175Gly Phe Asp Thr Thr Pro Phe
Met Tyr Asn Ala Met Ala Gly Ala Tyr 180 185 190Pro Ser Tyr Ser Thr
Asn Trp Ala Asp Glu Gln Val Leu Lys Ala Lys 195 200 205Asn Ile Gly
Leu Cys Ser Thr Asp Leu Thr Glu Gly Arg Arg Gly Lys 210 215 220Leu
Ser Ile Met Arg Gly Lys Lys Leu Lys Pro Cys Asp Arg Val Leu225 230
235 240Phe Ser Val Gly Ser Thr Leu Tyr Pro Glu Ser Arg Lys Leu Leu
Lys 245 250 255Ser Trp His Leu Pro Ser Val Phe His Leu Lys Gly Lys
Leu Ser Phe 260 265 270Thr Cys Arg Cys Asp Thr Val Val Ser Cys Glu
Gly Tyr Val Val Lys 275 280 285Arg Ile Thr Met Ser Pro Gly Leu Tyr
Gly Lys Thr Thr Gly Tyr Ala 290 295 300Val Thr His His Ala Asp Gly
Phe Leu Met Cys Lys Thr Thr Asp Thr305 310 315 320Val Asp Gly Glu
Arg Val Ser Phe Ser Val Cys Thr Tyr Val Pro Ala 325 330 335Thr Ile
Cys Asp Gln Met Thr Gly Ile Leu Ala Thr Glu Val Thr Pro 340 345
350Glu Asp Ala Gln Lys Leu Leu Val Gly Leu Asn Gln Arg Ile Val Val
355 360 365Asn Gly Arg Thr Gln Arg Asn Thr Asn Thr Met Lys Asn Tyr
Leu Leu 370 375 380Pro Val Val Ala Gln Ala Phe Ser Lys Trp Ala Lys
Glu Cys Arg Lys385 390 395 400Asp Met Glu Asp Glu Lys Leu Leu Gly
Val Arg Glu Arg Thr Leu Thr 405 410 415Cys Cys Cys Leu Trp Ala Phe
Lys Lys Gln Lys Thr His Thr Val Tyr 420 425 430Lys Arg Pro Asp Thr
Gln Ser Ile Gln Lys Val Gln Ala Glu Phe Asp 435 440 445Ser Phe Val
Val Pro Ser Leu Trp Ser Ser Gly Leu Ser Ile Pro Leu 450 455 460Arg
Thr Arg Ile Lys Trp Leu Leu Ser Lys Val Pro Lys Thr Asp Leu465 470
475 480Ile Pro Tyr Ser Gly Asp Ala Arg Glu Ala Arg Asp Ala Glu Lys
Glu 485 490 495Ala Glu Glu Glu Arg Glu Ala Glu Leu Thr Arg Glu Ala
Leu Pro Pro 500 505 510Leu Gln Ala Ala Gln Glu Asp Val Gln Val Glu
Ile Asp Val Glu Gln 515 520 525Leu Glu Asp Arg Ala Gly Ala Gly Ile
Ile Glu Thr Pro Arg Gly Ala 530 535 540Ile Lys Val Thr Ala Gln Pro
Thr Asp His Val Val Gly Glu Tyr Leu545 550 555 560Val Leu Ser Pro
Gln Thr Val Leu Arg Ser Gln Lys Leu Ser Leu Ile 565 570 575His Ala
Leu Ala Glu Gln Val Lys Thr Cys Thr His Asn Gly Arg Ala 580 585
590Gly Arg Tyr Ala Val Glu Ala Tyr Asp Gly Arg Val Leu Val Pro Ser
595 600 605Gly Tyr Ala Ile Ser Pro Glu Asp Phe Gln Ser Leu Ser Glu
Ser Ala 610 615 620Thr Met Val Tyr Asn Glu Arg Glu Phe Val Asn Arg
Lys Leu His His625 630 635 640Ile Ala Met His Gly Pro Ala Leu Asn
Thr Asp Glu Glu Ser Tyr Glu 645 650 655Leu Val Arg Ala Glu Arg Thr
Glu His Glu Tyr Val Tyr Asp Val Asp 660 665 670Gln Arg Arg Cys Cys
Lys Lys Glu Glu Ala Ala Gly Leu Val Leu Val 675 680 685Gly Asp Leu
Thr Asn Pro Pro Tyr His Glu Phe Ala Tyr Glu Gly Leu 690 695 700Lys
Ile Arg Pro Ala Cys Pro Tyr Lys Ile Ala Val Ile Gly Val Phe705 710
715 720Gly Val Pro Gly Ser Gly Lys Ser Ala Ile Ile Lys Asn Leu Val
Thr 725 730 735Arg Gln Asp Leu Val Thr Ser Gly Lys Lys Glu Asn Cys
Gln Glu Ile 740 745 750Thr Thr Asp Val Met Arg Gln Arg Gly Leu Glu
Ile Ser Ala Arg Thr 755 760 765Val Asp Ser Leu Leu Leu Asn Gly Cys
Asn Arg Pro Val Asp Val Leu 770 775 780Tyr Val Asp Glu Ala Phe Ala
Cys His Ser Gly Thr Leu Leu Ala Leu785 790 795 800Ile Ala Leu Val
Arg Pro Arg Gln Lys Val Val Leu Cys Gly Asp Pro 805 810 815Lys Gln
Cys Gly Phe Phe Asn Met Met Gln Met Lys Val Asn Tyr Asn 820 825
830His Asn Ile Cys Thr Gln Val Tyr His Lys Ser Ile Ser Arg Arg Cys
835 840 845Thr Leu Pro Val Thr Ala Ile Val Ser Ser Leu His Tyr Glu
Gly Lys 850 855 860Met Arg Thr Thr Asn Glu Tyr Asn Lys Pro Ile Val
Val Asp Thr Thr865 870 875 880Gly Ser Thr Lys Pro Asp Pro Gly Asp
Leu Val Leu Thr Cys Phe Arg 885 890 895Gly Trp Val Lys Gln Leu Gln
Ile Asp Tyr Arg Gly Tyr Glu Val Met 900 905 910Thr Ala Ala Ala Ser
Gln Gly Leu Thr Arg Lys Gly Val Tyr Ala Val 915 920 925Arg Gln Lys
Val Asn Glu Asn Pro Leu Tyr Ala Ser Thr Ser Glu His 930 935 940Val
Asn Val Leu Leu Thr Arg Thr Glu Gly Lys Leu Val Trp Lys Thr945 950
955 960Leu Ser Gly Asp Pro Trp Ile Lys Thr Leu Gln Asn Pro Pro Lys
Gly 965 970 975Asn Phe Lys Ala Thr Ile Lys Glu Trp Glu Val Glu His
Ala Ser Ile 980 985 990Met Ala Gly Ile Cys Ser His Gln Met Thr Phe
Asp Thr Phe Gln Asn 995 1000 1005Lys Ala Asn Val Cys Trp Ala Lys
Ser Leu Val Pro Ile Leu Glu 1010 1015 1020Thr Ala Gly Ile Lys Leu
Asn Asp Arg Gln Trp Ser Gln Ile Ile 1025 1030 1035Gln Ala Phe Lys
Glu Asp Lys Ala Tyr Ser Pro Glu Val Ala Leu 1040 1045 1050Asn Glu
Ile Cys Thr Arg Met Tyr Gly Val Asp Leu Asp Ser Gly 1055 1060
1065Leu Phe Ser Lys Pro Leu Val Ser Val Tyr Tyr Ala Asp
Asn His 1070 1075 1080Trp Asp Asn Arg Pro Gly Gly Lys Met Phe Gly
Phe Asn Pro Glu 1085 1090 1095Ala Ala Ser Ile Leu Glu Arg Lys Tyr
Pro Phe Thr Lys Gly Lys 1100 1105 1110Trp Asn Ile Asn Lys Gln Ile
Cys Val Thr Thr Arg Arg Ile Glu 1115 1120 1125Asp Phe Asn Pro Thr
Thr Asn Ile Ile Pro Ala Asn Arg Arg Leu 1130 1135 1140Pro His Ser
Leu Val Ala Glu His Arg Pro Val Lys Gly Glu Arg 1145 1150 1155Met
Glu Trp Leu Val Asn Lys Ile Asn Gly His His Val Leu Leu 1160 1165
1170Val Ser Gly Tyr Asn Leu Ala Leu Pro Thr Lys Arg Val Thr Trp
1175 1180 1185Val Ala Pro Leu Gly Val Arg Gly Ala Asp Tyr Thr Tyr
Asn Leu 1190 1195 1200Glu Leu Gly Leu Pro Ala Thr Leu Gly Arg Tyr
Asp Leu Val Val 1205 1210 1215Ile Asn Ile His Thr Pro Phe Arg Ile
His His Tyr Gln Gln Cys 1220 1225 1230Val Asp His Ala Met Lys Leu
Gln Met Leu Gly Gly Asp Ser Leu 1235 1240 1245Arg Leu Leu Lys Pro
Gly Gly Ser Leu Leu Ile Arg Ala Tyr Gly 1250 1255 1260Tyr Ala Asp
Arg Thr Ser Glu Arg Val Ile Cys Val Leu Gly Arg 1265 1270 1275Lys
Phe Arg Ser Ser Arg Ala Leu Lys Pro Pro Cys Val Thr Ser 1280 1285
1290Asn Thr Glu Met Phe Phe Leu Phe Ser Asn Phe Asp Asn Gly Arg
1295 1300 1305Arg Asn Phe Thr Thr His Val Met Asn Asn Gln Leu Asn
Ala Ala 1310 1315 1320Phe Val Gly Gln Val Thr Arg Ala Gly Cys Ala
Pro Ser Tyr Arg 1325 1330 1335Val Lys Arg Met Asp Ile Ala Lys Asn
Asp Glu Glu Cys Val Val 1340 1345 1350Asn Ala Ala Asn Pro Arg Gly
Leu Pro Gly Asp Gly Val Cys Lys 1355 1360 1365Ala Val Tyr Lys Lys
Trp Pro Glu Ser Phe Lys Asn Ser Ala Thr 1370 1375 1380Pro Val Gly
Thr Ala Lys Thr Val Met Cys Gly Thr Tyr Pro Val 1385 1390 1395Ile
His Ala Val Gly Pro Asn Phe Ser Asn Tyr Ser Glu Ser Glu 1400 1405
1410Gly Asp Arg Glu Leu Ala Ala Ala Tyr Arg Glu Val Ala Lys Glu
1415 1420 1425Val Thr Arg Leu Gly Val Asn Ser Val Ala Ile Pro Leu
Leu Ser 1430 1435 1440Thr Gly Val Tyr Ser Gly Gly Lys Asp Arg Leu
Thr Gln Ser Leu 1445 1450 1455Asn His Leu Phe Thr Ala Met Asp Ser
Thr Asp Ala Asp Val Val 1460 1465 1470Ile Tyr Cys Arg Asp Lys Glu
Trp Glu Lys Lys Ile Ser Glu Ala 1475 1480 1485Ile Gln Met Arg Thr
Gln Val Glu Leu Leu Asp Glu His Ile Ser 1490 1495 1500Ile Asp Cys
Asp Ile Val Arg Val His Pro Asp Ser Ser Leu Ala 1505 1510 1515Gly
Arg Lys Gly Tyr Ser Thr Thr Glu Gly Ala Leu Tyr Ser Tyr 1520 1525
1530Leu Glu Gly Thr Arg Phe His Gln Thr Ala Val Asp Met Ala Glu
1535 1540 1545Ile His Thr Met Trp Pro Lys Gln Thr Glu Ala Asn Glu
Gln Val 1550 1555 1560Cys Leu Tyr Ala Leu Gly Glu Ser Ile Glu Ser
Ile Arg Gln Lys 1565 1570 1575Cys Pro Val Asp Asp Ala Asp Ala Ser
Ser Pro Pro Lys Thr Val 1580 1585 1590Pro Cys Leu Cys Arg Tyr Ala
Met Thr Pro Glu Arg Val Thr Arg 1595 1600 1605Leu Arg Met Asn His
Val Thr Ser Ile Ile Val Cys Ser Ser Phe 1610 1615 1620Pro Leu Pro
Lys Tyr Lys Ile Glu Gly Val Gln Lys Val Lys Cys 1625 1630 1635Ser
Lys Val Met Leu Phe Asp His Asn Val Pro Ser Arg Val Ser 1640 1645
1650Pro Arg Glu Tyr Arg Ser Ser Gln Glu Ser Ala Gln Glu Ala Ser
1655 1660 1665Thr Ile Thr Ser Leu Thr His Ser Gln Phe Asp Leu Ser
Val Asp 1670 1675 1680Gly Glu Ile Leu Pro Val Pro Ser Asp Leu Asp
Ala Asp Ala Pro 1685 1690 1695Ala Leu Glu Pro Ala Leu Asp Asp Gly
Ala Thr His Thr Leu Pro 1700 1705 1710Ser Thr Thr Gly Asn Leu Ala
Ala Val Ser Asp Trp Val Met Ser 1715 1720 1725Thr Val Pro Val Ala
Pro Pro Arg Arg Arg Arg Gly Arg Asn Leu 1730 1735 1740Thr Val Thr
Cys Asp Glu Arg Glu Gly Asn Ile Thr Pro Met Ala 1745 1750 1755Ser
Val Arg Phe Phe Arg Ala Glu Leu Cys Pro Val Val Gln Glu 1760 1765
1770Thr Ala Glu Thr Arg Asp Thr Ala Met Ser Leu Gln Ala Pro Pro
1775 1780 1785Ser Thr Ala Thr Glu Pro Asn His Pro Pro Ile Ser Phe
Gly Ala 1790 1795 1800Ser Ser Glu Thr Phe Pro Ile Thr Phe Gly Asp
Phe Asn Glu Gly 1805 1810 1815Glu Ile Glu Ser Leu Ser Ser Glu Leu
Leu Thr Phe Gly Asp Phe 1820 1825 1830Leu Pro Gly Glu Val Asp Asp
Leu Thr Asp Ser Asp Trp Ser Thr 1835 1840 1845Cys Ser Asp Thr Asp
Asp Glu Leu Leu Asp Arg Ala Gly Gly Tyr 1850 1855 1860Ile Phe Ser
Ser Asp Thr Gly Pro Gly His Leu Gln Gln Lys Ser 1865 1870 1875Val
Arg Gln Ser Val Leu Pro Val Asn Thr Leu Glu Glu Val His 1880 1885
1890Glu Glu Lys Cys Tyr Pro Pro Lys Leu Asp Glu Ala Lys Glu Gln
1895 1900 1905Leu Leu Leu Lys Lys Leu Gln Glu Ser Ala Ser Met Ala
Asn Arg 1910 1915 1920Ser Arg Tyr Gln Ser Arg Lys Val Glu Asn Met
Lys Ala Ala Ile 1925 1930 1935Ile Gln Arg Leu Lys Arg Gly Cys Arg
Leu Tyr Leu Met Ser Glu 1940 1945 1950Thr Pro Lys Val Pro Thr Tyr
Arg Thr Thr Tyr Pro Ala Pro Val 1955 1960 1965Tyr Ser Pro Pro Ile
Asn Val Arg Leu Ser Asn Pro Glu Ser Ala 1970 1975 1980Val Ala Ala
Cys Asn Glu Phe Leu Ala Arg Asn Tyr Pro Thr Val 1985 1990 1995Ser
Ser Tyr Gln Ile Thr Asp Glu Tyr Asp Ala Tyr Leu Asp Met 2000 2005
2010Val Asp Gly Ser Glu Ser Cys Leu Asp Arg Ala Thr Phe Asn Pro
2015 2020 2025Ser Lys Leu Arg Ser Tyr Pro Lys Gln His Ala Tyr His
Ala Pro 2030 2035 2040Ser Ile Arg Ser Ala Val Pro Ser Pro Phe Gln
Asn Thr Leu Gln 2045 2050 2055Asn Val Leu Ala Ala Ala Thr Lys Arg
Asn Cys Asn Val Thr Gln 2060 2065 2070Met Arg Glu Leu Pro Thr Leu
Asp Ser Ala Val Phe Asn Val Glu 2075 2080 2085Cys Phe Lys Lys Phe
Ala Cys Asn Gln Glu Tyr Trp Glu Glu Phe 2090 2095 2100Ala Ala Ser
Pro Ile Arg Ile Thr Thr Glu Asn Leu Ala Thr Tyr 2105 2110 2115Val
Thr Lys Leu Lys Gly Pro Lys Ala Ala Ala Leu Phe Ala Lys 2120 2125
2130Thr His Asn Leu Leu Pro Leu Gln Glu Val Pro Met Asp Arg Phe
2135 2140 2145Thr Val Asp Met Lys Arg Asp Val Lys Val Thr Pro Gly
Thr Lys 2150 2155 2160His Thr Glu Glu Arg Pro Lys Val Gln Val Ile
Gln Ala Ala Glu 2165 2170 2175Pro Leu Ala Thr Ala Tyr Leu Cys Gly
Ile His Arg Glu Leu Val 2180 2185 2190Arg Arg Leu Asn Ala Val Leu
Leu Pro Asn Val His Thr Leu Phe 2195 2200 2205Asp Met Ser Ala Glu
Asp Phe Asp Ala Ile Ile Ala Ala His Phe 2210 2215 2220Lys Pro Gly
Asp Thr Val Leu Glu Thr Asp Ile Ala Ser Phe Asp 2225 2230 2235Lys
Ser Gln Asp Asp Ser Leu Ala Leu Thr Ala Leu Met Leu Leu 2240 2245
2250Glu Asp Leu Gly Val Asp His Ser Leu Leu Asp Leu Ile Glu Ala
2255 2260 2265Ala Phe Gly Glu Ile Ser Ser Cys His Leu Pro Thr Gly
Thr Arg 2270 2275 2280Phe Lys Phe Gly Ala Met Met Lys Ser Gly Met
Phe Leu Thr Leu 2285 2290 2295Phe Val Asn Thr Leu Leu Asn Ile Thr
Ile Ala Ser Arg Val Leu 2300 2305 2310Glu Asp Arg Leu Thr Lys Ser
Ala Cys Ala Ala Phe Ile Gly Asp 2315 2320 2325Asp Asn Ile Ile His
Gly Val Val Ser Asp Glu Leu Met Ala Ala 2330 2335 2340Arg Cys Ala
Thr Trp Met Asn Met Glu Val Lys Ile Ile Asp Ala 2345 2350 2355Val
Val Ser Leu Lys Ala Pro Tyr Phe Cys Gly Gly Phe Ile Leu 2360 2365
2370His Asp Thr Val Thr Gly Thr Ala Cys Arg Val Ala Asp Pro Leu
2375 2380 2385Lys Arg Leu Phe Lys Leu Gly Lys Pro Leu Ala Ala Gly
Asp Glu 2390 2395 2400Gln Asp Glu Asp Arg Arg Arg Ala Leu Ala Asp
Glu Val Ile Arg 2405 2410 2415Trp Gln Arg Thr Gly Leu Ile Asp Glu
Leu Glu Lys Ala Val Tyr 2420 2425 2430Ser Arg Tyr Glu Val Gln Gly
Ile Ser Val Val Val Met Ser Met 2435 2440 2445Ala Thr Phe Ala Ser
Ser Arg Ser Asn Phe Glu Lys Leu Arg Gly 2450 2455 2460Pro Val Ile
Thr Leu Tyr Gly Gly Pro Lys 2465 2470332473PRTChikungunya virus
33Met Asp Pro Val Tyr Val Asp Ile Asp Ala Asp Ser Ala Phe Leu Lys1
5 10 15Ala Leu Gln Arg Ala Tyr Pro Met Phe Glu Val Glu Pro Arg Gln
Val 20 25 30Thr Pro Asn Asp His Ala Asn Ala Arg Ala Phe Ser His Leu
Ala Ile 35 40 45Lys Leu Ile Glu Gln Glu Ile Asp Pro Asp Ser Thr Ile
Leu Asp Ile 50 55 60Gly Ser Ala Pro Ala Arg Arg Met Met Ser Asp Arg
Lys Tyr His Cys65 70 75 80Val Cys Pro Met Arg Ser Ala Glu Asp Pro
Glu Arg Leu Ala Asn Tyr 85 90 95Ala Arg Lys Leu Ala Ser Ala Ala Gly
Lys Val Leu Asp Arg Asn Ile 100 105 110Ser Gly Lys Ile Gly Asp Leu
Gln Ala Val Met Ala Val Pro Asp Thr 115 120 125Glu Thr Pro Thr Phe
Cys Leu His Thr Asp Val Ser Cys Arg Gln Arg 130 135 140Ala Asp Val
Ala Ile Tyr Gln Asp Val Tyr Ala Val His Ala Pro Thr145 150 155
160Ser Leu Tyr His Gln Ala Ile Lys Gly Val Arg Val Ala Tyr Trp Val
165 170 175Gly Phe Asp Thr Thr Pro Phe Met Tyr Asn Ala Met Ala Gly
Ala Tyr 180 185 190Pro Ser Tyr Ser Thr Asn Trp Ala Asp Glu Gln Val
Leu Lys Ala Lys 195 200 205Asn Ile Gly Leu Cys Ser Thr Asp Leu Thr
Glu Gly Arg Arg Gly Lys 210 215 220Leu Ser Ile Met Arg Gly Lys Lys
Leu Lys Pro Cys Asp Arg Val Leu225 230 235 240Phe Ser Val Gly Ser
Thr Leu Tyr Pro Glu Ser Arg Lys Leu Leu Lys 245 250 255Ser Trp His
Leu Pro Ser Val Phe His Leu Lys Gly Lys Leu Ser Phe 260 265 270Thr
Cys Arg Cys Asp Thr Val Val Ser Cys Glu Gly Tyr Val Val Lys 275 280
285Arg Ile Thr Met Ser Pro Gly Leu Tyr Gly Lys Thr Thr Gly Tyr Ala
290 295 300Val Thr His His Ala Asp Gly Phe Leu Met Cys Lys Thr Thr
Asp Thr305 310 315 320Val Asp Gly Glu Arg Val Ser Phe Ser Val Cys
Thr Tyr Val Pro Ala 325 330 335Thr Ile Cys Asp Gln Met Thr Gly Ile
Leu Ala Thr Glu Val Thr Pro 340 345 350Glu Asp Ala Gln Lys Leu Leu
Val Gly Leu Asn Gln Arg Ile Val Val 355 360 365Asn Gly Arg Thr Gln
Arg Asn Thr Asn Thr Met Lys Asn Tyr Leu Leu 370 375 380Pro Val Val
Ala Gln Ala Phe Ser Lys Trp Ala Lys Glu Cys Arg Lys385 390 395
400Asp Met Glu Asp Glu Lys Leu Leu Gly Val Arg Glu Arg Thr Leu Thr
405 410 415Cys Cys Cys Leu Trp Ala Phe Lys Lys Gln Lys Thr His Thr
Val Tyr 420 425 430Lys Arg Pro Asp Thr Gln Ser Ile Gln Lys Val Gln
Ala Glu Phe Asp 435 440 445Ser Phe Val Val Pro Ser Leu Trp Ser Ser
Gly Leu Ser Ile Pro Leu 450 455 460Arg Thr Arg Ile Lys Trp Leu Leu
Ser Lys Val Pro Lys Thr Asp Leu465 470 475 480Ile Pro Tyr Ser Gly
Asp Ala Arg Glu Ala Arg Asp Ala Glu Lys Glu 485 490 495Ala Glu Glu
Glu Arg Glu Ala Glu Leu Thr Arg Glu Ala Leu Pro Pro 500 505 510Leu
Gln Ala Ala Gln Glu Asp Val Gln Val Glu Ile Asp Val Glu Gln 515 520
525Leu Glu Asp Arg Ala Gly Ala Gly Ile Ile Glu Thr Pro Arg Gly Ala
530 535 540Ile Lys Val Thr Ala Gln Pro Thr Asp His Val Val Gly Glu
Tyr Leu545 550 555 560Val Leu Ser Pro Gln Thr Val Leu Arg Ser Gln
Lys Leu Ser Leu Ile 565 570 575His Ala Leu Ala Glu Gln Val Lys Thr
Cys Thr His Asn Gly Arg Ala 580 585 590Gly Arg Tyr Ala Val Glu Ala
Tyr Asp Gly Arg Val Leu Val Pro Ser 595 600 605Gly Tyr Ala Ile Ser
Pro Glu Asp Phe Gln Ser Leu Ser Glu Ser Ala 610 615 620Thr Met Val
Tyr Asn Glu Arg Glu Phe Val Asn Arg Lys Leu His His625 630 635
640Ile Ala Met His Gly Pro Ala Leu Asn Thr Asp Glu Glu Ser Tyr Glu
645 650 655Leu Val Arg Ala Glu Arg Thr Glu His Glu Tyr Val Tyr Asp
Val Asp 660 665 670Gln Arg Arg Cys Cys Lys Lys Glu Glu Ala Ala Gly
Leu Val Leu Val 675 680 685Gly Asp Leu Thr Asn Pro Pro Tyr His Glu
Phe Ala Tyr Glu Gly Leu 690 695 700Lys Ile Arg Pro Ala Cys Pro Tyr
Lys Ile Ala Val Ile Gly Val Phe705 710 715 720Gly Val Pro Gly Ser
Gly Lys Ser Ala Ile Ile Lys Asn Leu Val Thr 725 730 735Arg Gln Asp
Leu Val Thr Ser Gly Lys Lys Glu Asn Cys Gln Glu Ile 740 745 750Thr
Thr Asp Val Met Arg Gln Arg Gly Leu Glu Ile Ser Ala Arg Thr 755 760
765Val Asp Ser Leu Leu Leu Asn Gly Cys Asn Arg Pro Val Asp Val Leu
770 775 780Tyr Val Asp Glu Ala Phe Ala Cys His Ser Gly Thr Leu Leu
Ala Leu785 790 795 800Ile Ala Leu Val Arg Pro Arg Gln Lys Val Val
Leu Cys Gly Asp Pro 805 810 815Lys Gln Cys Gly Phe Phe Asn Met Met
Gln Met Lys Val Asn Tyr Asn 820 825 830His Asn Ile Cys Thr Gln Val
Tyr His Lys Ser Ile Ser Arg Arg Cys 835 840 845Thr Leu Pro Val Thr
Ala Ile Val Ser Ser Leu His Tyr Glu Gly Lys 850 855 860Met Arg Thr
Thr Asn Glu Tyr Asn Lys Pro Ile Val Val Asp Thr Thr865 870 875
880Gly Ser Thr Lys Pro Asp Pro Gly Asp Leu Val Leu Thr Cys Phe Arg
885 890 895Gly Trp Val Lys Gln Leu Gln Ile Asp Tyr Arg Gly Tyr Glu
Val Met 900 905 910Thr Ala Ala Ala Ser Gln Gly Leu Thr Arg Lys Gly
Val Tyr Ala Val 915 920 925Arg Gln Lys Val Asn Glu Asn Pro Leu Tyr
Ala Ser Thr Ser Glu His 930 935 940Val Asn Val Leu Leu Thr Arg Thr
Glu Gly Lys Leu Val Trp Lys Thr945 950 955 960Leu Ser Gly Asp Pro
Trp Ile Lys Thr Leu Gln Asn Pro Pro Lys Gly 965 970 975Asn Phe Lys
Ala Thr Ile Lys Glu Trp Glu Val Glu His Ala Ser Ile 980 985 990Met
Ala Gly Ile Cys Ser His Gln Met Thr Phe Asp Thr Phe Gln Asn 995
1000 1005Lys Ala Asn Val Cys Trp Ala Lys Ser Leu Val Pro Ile Leu
Glu 1010 1015 1020Thr Ala Gly Ile Lys Leu Asn Asp Arg Gln Trp Ser
Gln Ile Ile 1025 1030 1035Gln Ala Phe Lys Glu Asp Lys Ala Tyr Ser
Pro Glu Val Ala Leu 1040
1045 1050Asn Glu Ile Cys Thr Arg Met Tyr Gly Val Asp Leu Asp Ser
Gly 1055 1060 1065Leu Phe Ser Lys Pro Leu Val Ser Val Tyr Tyr Ala
Asp Asn His 1070 1075 1080Trp Asp Asn Arg Pro Gly Gly Lys Met Phe
Gly Phe Asn Pro Glu 1085 1090 1095Ala Ala Ser Ile Leu Glu Arg Lys
Tyr Pro Phe Thr Lys Gly Lys 1100 1105 1110Trp Asn Ile Asn Lys Gln
Ile Cys Val Thr Thr Arg Arg Ile Glu 1115 1120 1125Asp Phe Asn Pro
Thr Thr Asn Ile Ile Pro Ala Asn Arg Arg Leu 1130 1135 1140Pro His
Ser Leu Val Ala Glu His Arg Pro Val Lys Gly Glu Arg 1145 1150
1155Met Glu Trp Leu Val Asn Lys Ile Asn Gly His His Val Leu Leu
1160 1165 1170Val Ser Gly Tyr Asn Leu Ala Leu Pro Thr Lys Arg Val
Thr Trp 1175 1180 1185Val Ala Pro Leu Gly Val Arg Gly Ala Asp Tyr
Thr Tyr Asn Leu 1190 1195 1200Glu Leu Gly Leu Pro Ala Thr Leu Gly
Arg Tyr Asp Leu Val Val 1205 1210 1215Ile Asn Ile His Thr Pro Phe
Arg Ile His His Tyr Gln Gln Cys 1220 1225 1230Val Asp His Ala Met
Lys Leu Gln Met Leu Gly Gly Asp Ser Leu 1235 1240 1245Arg Leu Leu
Lys Pro Gly Gly Ser Leu Leu Ile Arg Ala Tyr Gly 1250 1255 1260Tyr
Ala Asp Arg Thr Ser Glu Arg Val Ile Cys Val Leu Gly Arg 1265 1270
1275Lys Phe Arg Ser Ser Arg Ala Leu Lys Pro Pro Cys Val Thr Ser
1280 1285 1290Asn Thr Glu Met Phe Phe Leu Phe Ser Asn Phe Asp Asn
Gly Arg 1295 1300 1305Arg Asn Phe Thr Thr His Val Met Asn Asn Gln
Leu Asn Ala Ala 1310 1315 1320Phe Val Gly Gln Val Thr Arg Ala Gly
Cys Ala Pro Ser Tyr Arg 1325 1330 1335Val Lys Arg Met Asp Ile Ala
Lys Asn Asp Glu Glu Cys Val Val 1340 1345 1350Asn Ala Ala Asn Pro
Arg Gly Leu Pro Gly Asp Gly Val Cys Lys 1355 1360 1365Ala Val Tyr
Lys Lys Trp Pro Glu Ser Phe Lys Asn Ser Ala Thr 1370 1375 1380Pro
Val Gly Thr Ala Lys Thr Val Met Cys Gly Thr Tyr Pro Val 1385 1390
1395Ile His Ala Val Gly Pro Asn Phe Ser Asn Tyr Ser Glu Ser Glu
1400 1405 1410Gly Asp Arg Glu Leu Ala Ala Ala Tyr Arg Glu Val Ala
Lys Glu 1415 1420 1425Val Thr Arg Leu Gly Val Asn Ser Val Ala Ile
Pro Leu Leu Ser 1430 1435 1440Thr Gly Val Tyr Ser Gly Gly Lys Asp
Arg Leu Thr Gln Ser Leu 1445 1450 1455Asn His Leu Phe Thr Ala Met
Asp Ser Thr Asp Ala Asp Val Val 1460 1465 1470Ile Tyr Cys Arg Asp
Lys Glu Trp Glu Lys Lys Ile Ser Glu Ala 1475 1480 1485Ile Gln Met
Arg Thr Gln Val Glu Leu Leu Asp Glu His Ile Ser 1490 1495 1500Ile
Asp Cys Asp Ile Val Arg Val His Pro Asp Ser Ser Leu Ala 1505 1510
1515Gly Arg Lys Gly Tyr Ser Thr Thr Glu Gly Ala Leu Tyr Ser Tyr
1520 1525 1530Leu Glu Gly Thr Arg Phe His Gln Thr Ala Val Asp Met
Ala Glu 1535 1540 1545Ile His Thr Met Trp Pro Lys Gln Thr Glu Ala
Asn Glu Gln Val 1550 1555 1560Cys Leu Tyr Ala Leu Gly Glu Ser Ile
Glu Ser Ile Arg Gln Lys 1565 1570 1575Cys Pro Val Asp Asp Ala Asp
Ala Ser Ser Pro Pro Lys Thr Val 1580 1585 1590Pro Cys Leu Cys Arg
Tyr Ala Met Thr Pro Glu Arg Val Thr Arg 1595 1600 1605Leu Arg Met
Asn His Val Thr Ser Ile Ile Val Cys Ser Ser Phe 1610 1615 1620Pro
Leu Pro Lys Tyr Lys Ile Glu Gly Val Gln Lys Val Lys Cys 1625 1630
1635Ser Lys Val Met Leu Phe Asp His Asn Val Pro Ser Arg Val Ser
1640 1645 1650Pro Arg Glu Tyr Arg Ser Ser Gln Glu Ser Ala Gln Glu
Ala Ser 1655 1660 1665Thr Ile Thr Ser Leu Thr His Ser Gln Phe Asp
Leu Ser Val Asp 1670 1675 1680Gly Glu Ile Leu Pro Val Pro Ser Asp
Leu Asp Ala Asp Ala Pro 1685 1690 1695Ala Leu Glu Pro Ala Leu Asp
Asp Gly Ala Thr His Thr Leu Pro 1700 1705 1710Ser Thr Thr Gly Asn
Leu Ala Ala Val Ser Asp Trp Val Met Ser 1715 1720 1725Thr Val Pro
Val Ala Pro Pro Arg Arg Arg Arg Gly Arg Asn Leu 1730 1735 1740Thr
Val Thr Cys Asp Glu Arg Glu Gly Asn Ile Thr Pro Met Ala 1745 1750
1755Ser Val Arg Phe Phe Arg Ala Glu Leu Cys Pro Val Val Gln Glu
1760 1765 1770Thr Ala Glu Thr Arg Asp Thr Ala Met Ser Leu Gln Ala
Pro Pro 1775 1780 1785Ser Thr Ala Thr Glu Pro Asn His Pro Pro Ile
Ser Phe Gly Ala 1790 1795 1800Ser Ser Glu Thr Phe Pro Ile Thr Phe
Gly Asp Phe Asn Glu Gly 1805 1810 1815Glu Ile Glu Ser Leu Ser Ser
Glu Leu Leu Thr Phe Gly Asp Phe 1820 1825 1830Leu Pro Gly Glu Val
Asp Asp Leu Thr Asp Ser Asp Trp Ser Thr 1835 1840 1845Cys Ser Asp
Thr Asp Asp Glu Leu Leu Asp Arg Ala Gly Gly Tyr 1850 1855 1860Ile
Phe Ser Ser Asp Thr Gly Pro Gly His Leu Gln Gln Lys Ser 1865 1870
1875Val Arg Gln Ser Val Leu Pro Val Asn Thr Leu Glu Glu Val His
1880 1885 1890Glu Glu Lys Cys Tyr Pro Pro Lys Leu Asp Glu Ala Lys
Glu Gln 1895 1900 1905Leu Leu Leu Lys Lys Leu Gln Glu Ser Ala Ser
Met Ala Asn Arg 1910 1915 1920Ser Arg Tyr Gln Ser Arg Lys Val Glu
Asn Met Lys Ala Ala Ile 1925 1930 1935Ile Gln Arg Leu Lys Arg Gly
Cys Arg Leu Tyr Leu Met Ser Glu 1940 1945 1950Thr Pro Lys Val Pro
Thr Tyr Arg Thr Thr Tyr Pro Ala Pro Val 1955 1960 1965Tyr Ser Pro
Pro Ile Asn Val Arg Leu Ser Asn Pro Glu Ser Ala 1970 1975 1980Val
Ala Ala Cys Asn Glu Phe Leu Ala Arg Asn Tyr Pro Thr Val 1985 1990
1995Ser Ser Tyr Gln Ile Thr Asp Glu Tyr Asp Ala Tyr Leu Asp Met
2000 2005 2010Val Asp Gly Ser Glu Ser Cys Leu Asp Arg Ala Thr Phe
Asn Pro 2015 2020 2025Ser Lys Leu Arg Ser Tyr Pro Lys Gln His Ala
Tyr His Ala Pro 2030 2035 2040Ser Ile Arg Ser Ala Val Pro Ser Pro
Phe Gln Asn Thr Leu Gln 2045 2050 2055Asn Val Leu Ala Ala Ala Thr
Lys Arg Asn Cys Asn Val Thr Gln 2060 2065 2070Met Arg Glu Leu Pro
Thr Leu Asp Ser Ala Val Phe Asn Val Glu 2075 2080 2085Cys Phe Lys
Lys Phe Ala Cys Asn Gln Glu Tyr Trp Glu Glu Phe 2090 2095 2100Ala
Ala Ser Pro Ile Arg Ile Thr Thr Glu Asn Leu Ala Thr Tyr 2105 2110
2115Val Thr Lys Leu Lys Gly Pro Lys Ala Ala Ala Leu Phe Ala Lys
2120 2125 2130Thr His Asn Leu Leu Pro Leu Gln Glu Val Pro Met Asp
Arg Phe 2135 2140 2145Thr Val Asp Met Lys Arg Asp Val Lys Val Thr
Pro Gly Thr Lys 2150 2155 2160His Thr Glu Glu Arg Pro Lys Val Gln
Val Ile Gln Ala Ala Glu 2165 2170 2175Pro Leu Ala Thr Ala Tyr Leu
Cys Gly Ile His Arg Glu Leu Val 2180 2185 2190Arg Arg Leu Asn Ala
Val Leu Leu Pro Asn Val His Thr Leu Phe 2195 2200 2205Asp Met Ser
Ala Glu Asp Phe Asp Ala Ile Ile Ala Ala His Phe 2210 2215 2220Lys
Pro Gly Asp Thr Val Leu Glu Thr Asp Ile Ala Ser Phe Asp 2225 2230
2235Lys Ser Gln Asp Asp Ser Leu Ala Leu Thr Ala Leu Met Leu Leu
2240 2245 2250Glu Asp Leu Gly Val Asp His Ser Leu Leu Asp Leu Ile
Glu Ala 2255 2260 2265Ala Phe Gly Glu Ile Ser Ser Cys His Leu Pro
Thr Gly Thr Arg 2270 2275 2280Phe Lys Phe Gly Ala Met Met Lys Ser
Gly Met Phe Leu Thr Leu 2285 2290 2295Phe Val Asn Thr Leu Leu Asn
Ile Thr Ile Ala Ser Arg Val Leu 2300 2305 2310Glu Asp Arg Leu Thr
Lys Ser Ala Cys Ala Ala Phe Ile Gly Asp 2315 2320 2325Asp Asn Ile
Ile His Gly Val Val Ser Asp Glu Leu Met Ala Ala 2330 2335 2340Arg
Cys Ala Thr Trp Met Asn Met Glu Val Lys Ile Ile Asp Ala 2345 2350
2355Val Val Ser Leu Lys Ala Pro Tyr Phe Cys Gly Gly Phe Ile Leu
2360 2365 2370His Asp Thr Val Thr Gly Thr Ala Cys Arg Val Ala Asp
Pro Leu 2375 2380 2385Lys Arg Leu Phe Lys Leu Gly Lys Pro Leu Ala
Ala Gly Asp Glu 2390 2395 2400Gln Asp Glu Asp Arg Arg Arg Ala Leu
Ala Asp Glu Val Ile Arg 2405 2410 2415Trp Gln Arg Thr Gly Leu Ile
Asp Glu Leu Glu Lys Ala Val Tyr 2420 2425 2430Ser Arg Tyr Glu Val
Gln Gly Ile Ser Val Val Val Met Ser Met 2435 2440 2445Ala Thr Phe
Ala Ser Ser Arg Ser Asn Phe Glu Lys Leu Arg Gly 2450 2455 2460Pro
Val Ile Thr Leu Tyr Gly Gly Pro Lys 2465 2470342472PRTChikungunya
virus 34Met Asp Pro Val Tyr Val Asp Ile Asp Ala Asp Ser Ala Phe Leu
Lys1 5 10 15Ala Leu Gln Arg Ala Tyr Pro Met Phe Glu Val Glu Pro Arg
Gln Val 20 25 30Thr Pro Asn Asp His Ala Asn Ala Arg Ala Phe Ser His
Leu Ala Ile 35 40 45Lys Leu Ile Glu Gln Glu Ile Asp Pro Asp Ser Thr
Ile Leu Asp Ile 50 55 60Gly Ser Ala Pro Ala Arg Arg Met Met Ser Asp
Arg Lys Tyr His Cys65 70 75 80Val Cys Pro Met Arg Ser Ala Glu Asp
Pro Glu Arg Leu Ala Asn Tyr 85 90 95Ala Arg Lys Leu Ala Ser Ala Ala
Gly Lys Val Leu Asp Arg Asn Ile 100 105 110Ser Gly Lys Ile Gly Asp
Leu Gln Ala Val Met Ala Val Pro Asp Thr 115 120 125Glu Thr Pro Thr
Phe Cys Leu His Thr Asp Val Ser Cys Arg Gln Arg 130 135 140Ala Asp
Val Ala Ile Tyr Gln Asp Val Tyr Ala Val His Ala Pro Thr145 150 155
160Ser Leu Tyr His Gln Ala Ile Lys Gly Val Arg Val Ala Tyr Trp Val
165 170 175Gly Phe Asp Thr Thr Pro Phe Met Tyr Asn Ala Met Ala Gly
Ala Tyr 180 185 190Pro Ser Tyr Ser Thr Asn Trp Ala Asp Glu Gln Val
Leu Lys Ala Lys 195 200 205Asn Ile Gly Leu Cys Ser Thr Asp Leu Thr
Glu Gly Arg Arg Gly Lys 210 215 220Leu Ser Ile Met Arg Gly Lys Lys
Leu Lys Pro Cys Asp Arg Val Leu225 230 235 240Phe Ser Val Gly Ser
Thr Leu Tyr Pro Glu Ser Arg Lys Leu Leu Lys 245 250 255Ser Trp His
Leu Pro Ser Val Phe His Leu Lys Gly Lys Leu Ser Phe 260 265 270Thr
Cys Arg Cys Asp Thr Val Val Ser Cys Glu Gly Tyr Val Val Lys 275 280
285Arg Ile Thr Met Ser Pro Gly Leu Tyr Gly Lys Thr Ile Gly Tyr Ala
290 295 300Val Thr His His Ala Asp Gly Phe Leu Met Cys Lys Thr Thr
Asp Thr305 310 315 320Val Asp Gly Glu Arg Val Ser Phe Ser Val Cys
Thr Tyr Val Pro Ala 325 330 335Thr Ile Cys Asp Gln Met Thr Gly Ile
Leu Ala Thr Glu Val Thr Pro 340 345 350Glu Asp Ala Gln Lys Leu Leu
Val Gly Leu Asn Gln Arg Ile Val Val 355 360 365Asn Gly Arg Thr Gln
Arg Asn Thr Asn Thr Met Lys Asn Tyr Leu Leu 370 375 380Pro Val Val
Ala Gln Ala Phe Ser Lys Trp Ala Lys Glu Cys Arg Lys385 390 395
400Asp Met Glu Asp Glu Lys Leu Leu Gly Val Arg Glu Arg Thr Leu Thr
405 410 415Cys Cys Cys Leu Trp Ala Phe Lys Lys Gln Lys Thr His Thr
Val Tyr 420 425 430Lys Arg Pro Asp Thr Gln Ser Ile Gln Lys Val Gln
Ala Glu Phe Asp 435 440 445Ser Phe Val Val Pro Ser Leu Trp Ser Ser
Gly Leu Ser Ile Pro Leu 450 455 460Arg Thr Arg Ile Lys Trp Leu Leu
Ser Lys Val Pro Lys Thr Asp Leu465 470 475 480Ile Pro Tyr Ser Gly
Asp Ala Arg Glu Ala Arg Asp Ala Glu Lys Glu 485 490 495Ala Glu Glu
Glu Arg Glu Ala Glu Leu Thr Arg Glu Ala Leu Pro Pro 500 505 510Leu
Gln Ala Ala Gln Glu Asp Val Gln Val Glu Ile Asp Val Glu Gln 515 520
525Leu Glu Asp Arg Ala Gly Ala Gly Ile Ile Glu Thr Pro Arg Gly Ala
530 535 540Ile Lys Val Thr Ala Gln Pro Thr Asp His Val Val Gly Glu
Tyr Leu545 550 555 560Val Leu Ser Pro Gln Thr Val Leu Arg Ser Gln
Lys Leu Ser Leu Ile 565 570 575His Ala Leu Ala Glu Gln Val Lys Thr
Cys Thr His Asn Gly Arg Ala 580 585 590Gly Arg Tyr Ala Val Glu Ala
Tyr Asp Gly Arg Val Leu Val Pro Ser 595 600 605Gly Tyr Ala Ile Ser
Pro Glu Asp Phe Gln Ser Leu Ser Glu Ser Ala 610 615 620Thr Met Val
Tyr Asn Glu Arg Glu Phe Val Asn Arg Lys Leu His His625 630 635
640Ile Ala Met His Gly Pro Ala Leu Asn Thr Asp Glu Glu Ser Tyr Glu
645 650 655Leu Val Arg Ala Glu Arg Thr Glu His Glu Tyr Val Tyr Asp
Val Asp 660 665 670Gln Arg Arg Cys Cys Lys Lys Glu Glu Ala Ala Gly
Leu Val Leu Val 675 680 685Gly Asp Leu Thr Asn Pro Pro Tyr His Glu
Phe Ala Tyr Glu Gly Leu 690 695 700Lys Ile Arg Pro Ala Cys Pro Tyr
Lys Ile Ala Val Ile Gly Val Phe705 710 715 720Gly Val Pro Gly Ser
Gly Lys Ser Ala Ile Ile Lys Asn Leu Val Thr 725 730 735Arg Gln Asp
Leu Val Thr Ser Gly Lys Lys Glu Asn Cys Gln Glu Ile 740 745 750Thr
Thr Asp Val Met Arg Gln Arg Gly Leu Glu Ile Ser Ala Arg Thr 755 760
765Val Asp Ser Leu Leu Leu Asn Gly Cys Asn Arg Pro Val Asp Val Leu
770 775 780Tyr Val Asp Glu Ala Phe Ala Cys His Ser Gly Thr Leu Leu
Ala Leu785 790 795 800Ile Ala Leu Val Arg Pro Arg Gln Lys Val Val
Leu Cys Gly Asp Pro 805 810 815Lys Gln Cys Gly Phe Phe Asn Met Met
Gln Met Lys Val Asn Tyr Asn 820 825 830His Asn Ile Cys Thr Gln Val
Tyr His Lys Ser Ile Ser Arg Arg Cys 835 840 845Thr Leu Pro Val Thr
Ala Ile Val Ser Ser Leu His Tyr Glu Gly Lys 850 855 860Met Arg Thr
Thr Asn Glu Tyr Asn Lys Pro Ile Val Val Asp Thr Thr865 870 875
880Gly Ser Thr Lys Pro Asp Pro Gly Asp Leu Val Leu Thr Cys Phe Arg
885 890 895Gly Trp Val Lys Gln Leu Gln Ile Asp Tyr Arg Gly Tyr Glu
Val Met 900 905 910Thr Ala Ala Ala Ser Gln Gly Leu Thr Arg Lys Gly
Val Tyr Ala Val 915 920 925Arg Gln Lys Val Asn Glu Asn Pro Leu Tyr
Ala Ser Thr Ser Glu His 930 935 940Val Asn Val Leu Leu Thr Arg Thr
Glu Gly Lys Leu Val Trp Lys Thr945 950 955 960Leu Ser Gly Asp Pro
Trp Ile Lys Thr Leu Gln Asn Pro Pro Lys Gly 965 970 975Asn Phe Lys
Ala Thr Ile Lys Glu Trp Glu Val Glu His Ala Ser Ile 980 985 990Met
Ala Gly Ile Cys Ser His Gln Met Thr Phe Asp Thr Phe Gln Asn 995
1000 1005Lys Ala Asn Val Cys Trp Ala Lys Ser Leu Val Pro Ile Leu
Glu 1010 1015
1020Thr Ala Gly Ile Lys Leu Asn Asp Arg Gln Trp Ser Gln Ile Ile
1025 1030 1035Gln Ala Phe Lys Glu Asp Lys Ala Tyr Ser Pro Glu Val
Ala Leu 1040 1045 1050Asn Glu Ile Cys Thr Arg Met Tyr Gly Val Asp
Leu Asp Ser Gly 1055 1060 1065Leu Phe Ser Lys Pro Leu Val Ser Val
Tyr Tyr Ala Asp Asn His 1070 1075 1080Trp Asp Asn Arg Pro Gly Gly
Lys Met Phe Gly Phe Asn Pro Glu 1085 1090 1095Ala Ala Ser Ile Leu
Glu Arg Lys Tyr Pro Phe Thr Lys Gly Lys 1100 1105 1110Trp Asn Ile
Asn Lys Gln Ile Cys Val Thr Thr Arg Arg Ile Glu 1115 1120 1125Asp
Phe Asn Pro Thr Thr Asn Ile Ile Pro Ala Asn Arg Arg Leu 1130 1135
1140Pro His Ser Leu Val Ala Glu His Arg Pro Val Lys Gly Glu Arg
1145 1150 1155Met Glu Trp Leu Val Asn Lys Ile Asn Gly His His Val
Leu Leu 1160 1165 1170Val Ser Gly Asn Asn Leu Ala Leu Pro Thr Lys
Arg Val Thr Trp 1175 1180 1185Val Ala Pro Leu Gly Val Arg Gly Ala
Asp Tyr Thr Tyr Asn Leu 1190 1195 1200Glu Leu Gly Leu Pro Ala Thr
Leu Gly Arg Tyr Asp Leu Val Val 1205 1210 1215Ile Asn Ile His Thr
Pro Phe Arg Ile His His Tyr Gln Gln Cys 1220 1225 1230Val Asp His
Ala Met Lys Leu Gln Met Leu Gly Gly Asp Ser Leu 1235 1240 1245Arg
Leu Leu Lys Pro Gly Gly Ser Leu Leu Ile Arg Ala Tyr Gly 1250 1255
1260Tyr Ala Asp Arg Thr Ser Glu Arg Val Ile Cys Val Leu Gly Arg
1265 1270 1275Lys Phe Arg Ser Ser Arg Ala Leu Lys Pro Pro Cys Val
Thr Ser 1280 1285 1290Asn Thr Glu Met Phe Phe Leu Phe Ser Asn Phe
Asp Asn Gly Arg 1295 1300 1305Arg Asn Phe Thr Thr His Val Met Asn
Asn Gln Leu Asn Ala Ala 1310 1315 1320Phe Val Gly Gln Val Thr Arg
Ala Gly Cys Ala Pro Ser Tyr Arg 1325 1330 1335Val Lys Arg Met Asp
Ile Ala Lys Asn Asp Glu Glu Cys Val Val 1340 1345 1350Asn Ala Ala
Asn Pro Arg Gly Leu Pro Gly Asp Gly Val Cys Lys 1355 1360 1365Ala
Val Tyr Lys Lys Trp Pro Glu Ser Phe Lys Asn Ser Ala Thr 1370 1375
1380Pro Val Gly Thr Ala Lys Thr Val Met Cys Gly Thr Tyr Pro Val
1385 1390 1395Ile His Ala Val Gly Pro Asn Phe Ser Asn Tyr Ser Glu
Ser Glu 1400 1405 1410Gly Asp Arg Glu Leu Ala Ala Ala Tyr Arg Glu
Val Ala Lys Glu 1415 1420 1425Val Thr Arg Leu Gly Val Asn Ser Val
Ala Ile Pro Leu Leu Ser 1430 1435 1440Thr Gly Val Tyr Ser Gly Gly
Lys Asp Arg Leu Thr Gln Ser Leu 1445 1450 1455Asn His Leu Phe Thr
Ala Met Asp Ser Thr Asp Ala Asp Val Val 1460 1465 1470Ile Tyr Cys
Arg Asp Lys Glu Trp Glu Lys Lys Ile Ser Glu Ala 1475 1480 1485Ile
Gln Met Arg Thr Gln Val Glu Leu Leu Asp Glu His Ile Ser 1490 1495
1500Ile Asp Cys Asp Ile Val Arg Val His Pro Asp Ser Ser Leu Ala
1505 1510 1515Gly Arg Lys Gly Tyr Ser Thr Thr Glu Gly Ala Leu Tyr
Ser Tyr 1520 1525 1530Leu Glu Gly Thr Arg Phe His Gln Thr Ala Val
Asp Met Ala Glu 1535 1540 1545Ile His Thr Met Trp Pro Lys Gln Thr
Glu Ala Asn Glu Gln Val 1550 1555 1560Cys Leu Tyr Ala Leu Gly Glu
Ser Ile Glu Ser Ile Arg Gln Lys 1565 1570 1575Cys Pro Val Asp Asp
Ala Asp Ala Ser Ser Pro Pro Lys Thr Val 1580 1585 1590Pro Cys Leu
Cys Arg Tyr Ala Met Thr Pro Glu Arg Val Thr Arg 1595 1600 1605Leu
Arg Met Asn His Val Thr Ser Ile Ile Val Cys Ser Ser Phe 1610 1615
1620Pro Leu Pro Lys Tyr Lys Ile Glu Gly Val Gln Lys Val Lys Cys
1625 1630 1635Ser Lys Val Met Leu Phe Asp His Asn Val Pro Ser Arg
Val Ser 1640 1645 1650Pro Arg Glu Tyr Arg Ser Ser Gln Glu Ser Ala
Gln Glu Ala Ser 1655 1660 1665Thr Ile Thr Ser Leu Thr His Ser Gln
Phe Asp Leu Ser Val Asp 1670 1675 1680Gly Glu Ile Leu Pro Val Pro
Ser Asp Leu Asp Ala Asp Ala Pro 1685 1690 1695Ala Leu Glu Pro Ala
Leu Asp Asp Gly Ala Thr His Thr Leu Pro 1700 1705 1710Ser Thr Thr
Gly Asn Leu Ala Ala Val Ser Asp Trp Val Met Ser 1715 1720 1725Thr
Val Pro Val Ala Pro Pro Arg Arg Arg Arg Gly Arg Asn Leu 1730 1735
1740Thr Val Thr Cys Asp Glu Arg Glu Gly Asn Ile Thr Pro Met Ala
1745 1750 1755Ser Val Arg Phe Phe Arg Ala Glu Leu Cys Pro Val Val
Gln Glu 1760 1765 1770Thr Ala Glu Thr Arg Asp Thr Ala Met Ser Leu
Gln Ala Pro Pro 1775 1780 1785Ser Thr Ala Thr Pro Asn His Pro Pro
Ile Ser Phe Gly Ala Ser 1790 1795 1800Ser Glu Thr Phe Pro Ile Thr
Phe Gly Asp Phe Asn Glu Gly Glu 1805 1810 1815Ile Glu Ser Leu Ser
Ser Glu Leu Leu Thr Phe Gly Asp Phe Leu 1820 1825 1830Pro Gly Glu
Val Asp Asp Leu Thr Asp Ser Asp Trp Ser Thr Cys 1835 1840 1845Ser
Asp Thr Asp Asp Glu Leu Leu Asp Arg Ala Gly Gly Tyr Ile 1850 1855
1860Phe Ser Ser Asp Thr Gly Pro Gly His Leu Gln Gln Lys Ser Val
1865 1870 1875Arg Gln Ser Val Leu Pro Val Asn Thr Leu Glu Glu Val
His Glu 1880 1885 1890Glu Lys Cys Tyr Pro Pro Lys Leu Asp Glu Ala
Lys Glu Gln Leu 1895 1900 1905Leu Leu Lys Lys Leu Gln Glu Ser Ala
Ser Met Ala Asn Arg Ser 1910 1915 1920Arg Tyr Gln Ser Arg Lys Val
Glu Asn Met Lys Ala Ala Ile Ile 1925 1930 1935Gln Arg Leu Lys Arg
Gly Cys Arg Leu Tyr Leu Met Ser Glu Thr 1940 1945 1950Pro Lys Val
Pro Thr Tyr Arg Thr Thr Tyr Pro Ala Pro Val Tyr 1955 1960 1965Ser
Pro Pro Ile Asn Val Arg Leu Ser Asn Pro Glu Ser Ala Val 1970 1975
1980Ala Ala Cys Asn Glu Phe Leu Ala Arg Asn Tyr Pro Thr Val Ser
1985 1990 1995Ser Tyr Gln Ile Thr Asp Glu Tyr Asp Ala Tyr Leu Asp
Met Val 2000 2005 2010Asp Gly Ser Glu Ser Cys Leu Asp Arg Ala Thr
Phe Asn Pro Ser 2015 2020 2025Lys Leu Arg Ser Tyr Pro Lys Gln His
Ala Tyr His Ala Pro Ser 2030 2035 2040Ile Arg Ser Ala Val Pro Ser
Pro Phe Gln Asn Thr Leu Gln Asn 2045 2050 2055Val Leu Ala Ala Ala
Thr Lys Arg Asn Cys Asn Val Thr Gln Met 2060 2065 2070Arg Glu Leu
Pro Thr Leu Asp Ser Ala Val Phe Asn Val Glu Cys 2075 2080 2085Phe
Lys Lys Phe Ala Cys Asn Gln Glu Tyr Trp Glu Glu Phe Ala 2090 2095
2100Ala Ser Pro Ile Arg Ile Thr Thr Glu Asn Leu Ala Thr Tyr Val
2105 2110 2115Thr Lys Leu Lys Gly Pro Lys Ala Ala Ala Leu Phe Ala
Lys Thr 2120 2125 2130His Asn Leu Leu Pro Leu Gln Glu Val Pro Met
Asp Arg Phe Thr 2135 2140 2145Val Asp Met Lys Arg Asp Val Lys Val
Thr Pro Gly Thr Lys His 2150 2155 2160Thr Glu Glu Arg Pro Lys Val
Gln Val Ile Gln Ala Ala Glu Pro 2165 2170 2175Leu Ala Thr Ala Tyr
Leu Cys Gly Ile His Arg Glu Leu Val Arg 2180 2185 2190Arg Leu Asn
Ala Val Leu Leu Pro Asn Val His Thr Leu Phe Asp 2195 2200 2205Met
Ser Ala Glu Asp Phe Asp Ala Ile Ile Ala Ala His Phe Lys 2210 2215
2220Pro Gly Asp Thr Val Leu Glu Thr Asp Ile Ala Ser Phe Asp Lys
2225 2230 2235Ser Gln Asp Asp Ser Leu Ala Leu Thr Ala Leu Met Leu
Leu Glu 2240 2245 2250Asp Leu Gly Val Asp His Ser Leu Leu Asp Leu
Ile Glu Ala Ala 2255 2260 2265Phe Gly Glu Ile Ser Ser Cys His Leu
Pro Thr Gly Thr Arg Phe 2270 2275 2280Lys Phe Gly Ala Met Met Lys
Ser Gly Met Phe Leu Thr Leu Phe 2285 2290 2295Val Asn Thr Leu Leu
Asn Ile Thr Ile Ala Ser Arg Val Leu Glu 2300 2305 2310Asp Arg Leu
Thr Lys Ser Ala Cys Ala Ala Phe Ile Gly Asp Asp 2315 2320 2325Asn
Ile Ile His Gly Val Val Ser Asp Glu Leu Met Ala Ala Arg 2330 2335
2340Cys Ala Thr Trp Met Asn Met Glu Val Lys Ile Ile Asp Ala Val
2345 2350 2355Val Ser Leu Lys Ala Pro Tyr Phe Cys Gly Gly Phe Ile
Leu His 2360 2365 2370Asp Thr Val Thr Gly Thr Ala Cys Arg Val Ala
Asp Pro Leu Lys 2375 2380 2385Arg Leu Phe Lys Leu Gly Lys Pro Leu
Ala Ala Gly Asp Glu Gln 2390 2395 2400Asp Glu Asp Arg Arg Arg Ala
Leu Ala Asp Glu Val Ile Arg Trp 2405 2410 2415Gln Arg Thr Gly Leu
Ile Asp Glu Leu Glu Lys Ala Val Tyr Ser 2420 2425 2430Arg Tyr Glu
Val Gln Gly Ile Ser Val Val Val Met Ser Met Ala 2435 2440 2445Thr
Phe Ala Ser Ser Arg Ser Asn Phe Glu Lys Leu Arg Gly Pro 2450 2455
2460Val Ile Thr Leu Tyr Gly Gly Pro Lys 2465 24703522DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
35cacgtagcct accagtttct ta 223621DNAArtificial SequenceDescription
of Artificial Sequence Synthetic primer 36atggaacacc gatggtaggt g
213721DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 37aaccccgttc atgtacaatg c 213822DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
38cggtaccaca aagctgtcaa ac 223922DNAArtificial SequenceDescription
of Artificial Sequence Synthetic primer 39cactgacctg ctgctgtcta tg
224021DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 40agtcctgcag cttcttcctt c 214122DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
41cgagtttgac agctttgtgg ta 224222DNAArtificial SequenceDescription
of Artificial Sequence Synthetic primer 42atgactgcaa ttttgtatgg gc
224321DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 43caatctcgcc tgaagacttc c 214421DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
44tccactacaa tcggcttgtt g 214522DNAArtificial SequenceDescription
of Artificial Sequence Synthetic primer 45gtgcggcttc ttcaatatga tg
224621DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 46tccaggccta ttatcccagt g 214722DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
47aacatctgca cccaagtgta cc 224822DNAArtificial SequenceDescription
of Artificial Sequence Synthetic primer 48gtctcctgtt ggccggtata at
224922DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 49taataggcct ggagggaaga tg 225022DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
50ctacgcactc ttcatcgttc tt 225122DNAArtificial SequenceDescription
of Artificial Sequence Synthetic primer 51gaacgagtca tctgcgtatt gg
225222DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 52atatctctgc catatccact gc 225322DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
53tctttacagc catggactcg ac 225422DNAArtificial SequenceDescription
of Artificial Sequence Synthetic primer 54cgacaggtac ggtgctcatt ac
225522DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 55tgtacaggaa gcgagtacga cc 225622DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
56tctactttgc gcgactgata cc 225722DNAArtificial SequenceDescription
of Artificial Sequence Synthetic primer 57acggacgacg agttacgact ag
225821DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 58cccagtattc ttggttgcat g 215920DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
59aaaacagcac gcttaccacg 206021DNAArtificial SequenceDescription of
Artificial Sequence Synthetic primer 60aacttgaagc gcgtacctgt c
216121DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 61tcatagccgc acactttaag c 216221DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
62aggaccgccg tacaaagtta c 216321DNAArtificial SequenceDescription
of Artificial Sequence Synthetic primer 63gcaggtgacg aacaagatga g
216419DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 64ccgcttaaag gccaatttg 196519DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
65tcgaagtcaa gcacgaagg 196622DNAArtificial SequenceDescription of
Artificial Sequence Synthetic primer 66gtctgtcgct tcatttctga tg
226722DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 67tgcttgagga caacgtcatg ag 226819DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
68tttgtgattg gtgaccgcg 196922DNAArtificial SequenceDescription of
Artificial Sequence Synthetic primer 69agtccggcaa cgtaaagatc ac
227021DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 70aaaggttgct gctcgttcca c 217122DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
71agttgtgtca gtggcctcgt tc 227222DNAArtificial SequenceDescription
of Artificial Sequence Synthetic primer 72taaaggacgc ggagcttagc tg
227321DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 73acaaaaccgt catcccgtct c 217422DNAArtificial
SequenceDescription of Artificial Sequence Synthetic primer
74tgactatgtg gtccttcgga gg 227521DNAArtificial SequenceDescription
of Artificial Sequence Synthetic primer 75cagcaagaaa ggcaagtgtg c
217620DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 76tttgccaatt atggtattca 207717PRTChikungunya virus
77Met Leu Leu Ser Val Pro Leu Leu Leu Leu Gly Leu Leu Gly Leu Ala1
5 10 15Ala782450PRTChikungunya virus 78Met Phe Glu Val Glu Pro Arg
Gln Val Thr Pro Asn Asp His Ala Asn1 5 10 15Ala Arg Ala Phe Ser His
Leu Ala Ile Lys Leu Ile Glu Gln Glu Ile 20 25 30Asp Pro Asp Ser Thr
Ile Leu Asp Ile Gly Ser Ala Pro Ala Arg Arg 35 40 45Met Met Ser Asp
Arg Lys Tyr His Cys Val Cys Pro Met Arg Ser Ala 50 55 60Glu Asp
Pro
Glu Arg Leu Ala Asn Tyr Ala Arg Lys Leu Ala Ser Ala65 70 75 80Ala
Gly Lys Val Leu Asp Arg Asn Ile Ser Gly Lys Ile Gly Asp Leu 85 90
95Gln Ala Val Met Ala Val Pro Asp Thr Glu Thr Pro Thr Phe Cys Leu
100 105 110His Thr Asp Val Ser Cys Arg Gln Arg Ala Asp Val Ala Ile
Tyr Gln 115 120 125Asp Val Tyr Ala Val His Ala Pro Thr Ser Leu Tyr
His Gln Ala Ile 130 135 140Lys Gly Val Arg Val Ala Tyr Trp Val Gly
Phe Asp Thr Thr Pro Phe145 150 155 160Met Tyr Asn Ala Met Ala Gly
Ala Tyr Pro Ser Tyr Ser Thr Asn Trp 165 170 175Ala Asp Glu Gln Val
Leu Lys Ala Lys Asn Ile Gly Leu Cys Ser Thr 180 185 190Asp Leu Thr
Glu Gly Arg Arg Gly Lys Leu Ser Ile Met Arg Gly Lys 195 200 205Lys
Leu Lys Pro Cys Asp Arg Val Leu Phe Ser Val Gly Ser Thr Leu 210 215
220Tyr Pro Glu Ser Arg Lys Leu Leu Lys Ser Trp His Leu Pro Ser
Val225 230 235 240Phe His Leu Lys Gly Lys Leu Ser Phe Thr Cys Arg
Cys Asp Thr Val 245 250 255Val Ser Cys Glu Gly Tyr Val Val Lys Arg
Ile Thr Met Ser Pro Gly 260 265 270Leu Tyr Gly Lys Thr Thr Gly Tyr
Ala Val Thr His His Ala Asp Gly 275 280 285Phe Leu Met Cys Lys Thr
Thr Asp Thr Val Asp Gly Glu Arg Val Ser 290 295 300Phe Ser Val Cys
Thr Tyr Val Pro Ala Thr Ile Cys Asp Gln Met Thr305 310 315 320Gly
Ile Leu Ala Thr Glu Val Thr Pro Glu Asp Ala Gln Lys Leu Leu 325 330
335Val Gly Leu Asn Gln Arg Ile Val Val Asn Gly Arg Thr Gln Arg Asn
340 345 350Thr Asn Thr Met Lys Asn Tyr Leu Leu Pro Val Val Ala Gln
Ala Phe 355 360 365Ser Lys Trp Ala Lys Glu Cys Arg Lys Asp Met Glu
Asp Glu Lys Leu 370 375 380Leu Gly Val Arg Glu Arg Thr Leu Thr Cys
Cys Cys Leu Trp Ala Phe385 390 395 400Lys Lys Gln Lys Thr His Thr
Val Tyr Lys Arg Pro Asp Thr Gln Ser 405 410 415Ile Gln Lys Val Gln
Ala Glu Phe Asp Ser Phe Val Val Pro Ser Leu 420 425 430Trp Ser Ser
Gly Leu Ser Ile Pro Leu Arg Thr Arg Ile Lys Trp Leu 435 440 445Leu
Ser Lys Val Pro Lys Thr Asp Leu Ile Pro Tyr Ser Gly Asp Ala 450 455
460Arg Glu Ala Arg Asp Ala Glu Lys Glu Ala Glu Glu Glu Arg Glu
Ala465 470 475 480Glu Leu Thr Arg Glu Ala Leu Pro Pro Leu Gln Ala
Ala Gln Glu Asp 485 490 495Val Gln Val Glu Ile Asp Val Glu Gln Leu
Glu Asp Arg Ala Gly Ala 500 505 510Gly Ile Ile Glu Thr Pro Arg Gly
Ala Ile Lys Val Thr Ala Gln Pro 515 520 525Thr Asp His Val Val Gly
Glu Tyr Leu Val Leu Ser Pro Gln Thr Val 530 535 540Leu Arg Ser Gln
Lys Leu Ser Leu Ile His Ala Leu Ala Glu Gln Val545 550 555 560Lys
Thr Cys Thr His Asn Gly Arg Ala Gly Arg Tyr Ala Val Glu Ala 565 570
575Tyr Asp Gly Arg Val Leu Val Pro Ser Gly Tyr Ala Ile Ser Pro Glu
580 585 590Asp Phe Gln Ser Leu Ser Glu Ser Ala Thr Met Val Tyr Asn
Glu Arg 595 600 605Glu Phe Val Asn Arg Lys Leu His His Ile Ala Met
His Gly Pro Ala 610 615 620Leu Asn Thr Asp Glu Glu Ser Tyr Glu Leu
Val Arg Ala Glu Arg Thr625 630 635 640Glu His Glu Tyr Val Tyr Asp
Val Asp Gln Arg Arg Cys Cys Lys Lys 645 650 655Glu Glu Ala Ala Gly
Leu Val Leu Val Gly Asp Leu Thr Asn Pro Pro 660 665 670Tyr His Glu
Phe Ala Tyr Glu Gly Leu Lys Ile Arg Pro Ala Cys Pro 675 680 685Tyr
Lys Ile Ala Val Ile Gly Val Phe Gly Val Pro Gly Ser Gly Lys 690 695
700Ser Ala Ile Ile Lys Asn Leu Val Thr Arg Gln Asp Leu Val Thr
Ser705 710 715 720Gly Lys Lys Glu Asn Cys Gln Glu Ile Thr Thr Asp
Val Met Arg Gln 725 730 735Arg Gly Leu Glu Ile Ser Ala Arg Thr Val
Asp Ser Leu Leu Leu Asn 740 745 750Gly Cys Asn Arg Pro Val Asp Val
Leu Tyr Val Asp Glu Ala Phe Ala 755 760 765Cys His Ser Gly Thr Leu
Leu Ala Leu Ile Ala Leu Val Arg Pro Arg 770 775 780Gln Lys Val Val
Leu Cys Gly Asp Pro Lys Gln Cys Gly Phe Phe Asn785 790 795 800Met
Met Gln Met Lys Val Asn Tyr Asn His Asn Ile Cys Thr Gln Val 805 810
815Tyr His Lys Ser Ile Ser Arg Arg Cys Thr Leu Pro Val Thr Ala Ile
820 825 830Val Ser Ser Leu His Tyr Glu Gly Lys Met Arg Thr Thr Asn
Glu Tyr 835 840 845Asn Lys Pro Ile Val Val Asp Thr Thr Gly Ser Thr
Lys Pro Asp Pro 850 855 860Gly Asp Leu Val Leu Thr Cys Phe Arg Gly
Trp Val Lys Gln Leu Gln865 870 875 880Ile Asp Tyr Arg Gly Tyr Glu
Val Met Thr Ala Ala Ala Ser Gln Gly 885 890 895Leu Thr Arg Lys Gly
Val Tyr Ala Val Arg Gln Lys Val Asn Glu Asn 900 905 910Pro Leu Tyr
Ala Ser Thr Ser Glu His Val Asn Val Leu Leu Thr Arg 915 920 925Thr
Glu Gly Lys Leu Val Trp Lys Thr Leu Ser Gly Asp Pro Trp Ile 930 935
940Lys Thr Leu Gln Asn Pro Pro Lys Gly Asn Phe Lys Ala Thr Ile
Lys945 950 955 960Glu Trp Glu Val Glu His Ala Ser Ile Met Ala Gly
Ile Cys Ser His 965 970 975Gln Met Thr Phe Asp Thr Phe Gln Asn Lys
Ala Asn Val Cys Trp Ala 980 985 990Lys Ser Leu Val Pro Ile Leu Glu
Thr Ala Gly Ile Lys Leu Asn Asp 995 1000 1005Arg Gln Trp Ser Gln
Ile Ile Gln Ala Phe Lys Glu Asp Lys Ala 1010 1015 1020Tyr Ser Pro
Glu Val Ala Leu Asn Glu Ile Cys Thr Arg Met Tyr 1025 1030 1035Gly
Val Asp Leu Asp Ser Gly Leu Phe Ser Lys Pro Leu Val Ser 1040 1045
1050Val Tyr Tyr Ala Asp Asn His Trp Asp Asn Arg Pro Gly Gly Lys
1055 1060 1065Met Phe Gly Phe Asn Pro Glu Ala Ala Ser Ile Leu Glu
Arg Lys 1070 1075 1080Tyr Pro Phe Thr Lys Gly Lys Trp Asn Ile Asn
Lys Gln Ile Cys 1085 1090 1095Val Thr Thr Arg Arg Ile Glu Asp Phe
Asn Pro Thr Thr Asn Ile 1100 1105 1110Ile Pro Ala Asn Arg Arg Leu
Pro His Ser Leu Val Ala Glu His 1115 1120 1125Arg Pro Val Lys Gly
Glu Arg Met Glu Trp Leu Val Asn Lys Ile 1130 1135 1140Asn Gly His
His Val Leu Leu Val Ser Gly Tyr Asn Leu Ala Leu 1145 1150 1155Pro
Thr Lys Arg Val Thr Trp Val Ala Pro Leu Gly Val Arg Gly 1160 1165
1170Ala Asp Tyr Thr Tyr Asn Leu Glu Leu Gly Leu Pro Ala Thr Leu
1175 1180 1185Gly Arg Tyr Asp Leu Val Val Ile Asn Ile His Thr Pro
Phe Arg 1190 1195 1200Ile His His Tyr Gln Gln Cys Val Asp His Ala
Met Lys Leu Gln 1205 1210 1215Met Leu Gly Gly Asp Ser Leu Arg Leu
Leu Lys Pro Gly Gly Ser 1220 1225 1230Leu Leu Ile Arg Ala Tyr Gly
Tyr Ala Asp Arg Thr Ser Glu Arg 1235 1240 1245Val Ile Cys Val Leu
Gly Arg Lys Phe Arg Ser Ser Arg Ala Leu 1250 1255 1260Lys Pro Pro
Cys Val Thr Ser Asn Thr Glu Met Phe Phe Leu Phe 1265 1270 1275Ser
Asn Phe Asp Asn Gly Arg Arg Asn Phe Thr Thr His Val Met 1280 1285
1290Asn Asn Gln Leu Asn Ala Ala Phe Val Gly Gln Val Thr Arg Ala
1295 1300 1305Gly Cys Ala Pro Ser Tyr Arg Val Lys Arg Met Asp Ile
Ala Lys 1310 1315 1320Asn Asp Glu Glu Cys Val Val Asn Ala Ala Asn
Pro Arg Gly Leu 1325 1330 1335Pro Gly Asp Gly Val Cys Lys Ala Val
Tyr Lys Lys Trp Pro Glu 1340 1345 1350Ser Phe Lys Asn Ser Ala Thr
Pro Val Gly Thr Ala Lys Thr Val 1355 1360 1365Met Cys Gly Thr Tyr
Pro Val Ile His Ala Val Gly Pro Asn Phe 1370 1375 1380Ser Asn Tyr
Ser Glu Ser Glu Gly Asp Arg Glu Leu Ala Ala Ala 1385 1390 1395Tyr
Arg Glu Val Ala Lys Glu Val Thr Arg Leu Gly Val Asn Ser 1400 1405
1410Val Ala Ile Pro Leu Leu Ser Thr Gly Val Tyr Ser Gly Gly Lys
1415 1420 1425Asp Arg Leu Thr Gln Ser Leu Asn His Leu Phe Thr Ala
Met Asp 1430 1435 1440Ser Thr Asp Ala Asp Val Val Ile Tyr Cys Arg
Asp Lys Glu Trp 1445 1450 1455Glu Lys Lys Ile Ser Glu Ala Ile Gln
Met Arg Thr Gln Val Glu 1460 1465 1470Leu Leu Asp Glu His Ile Ser
Ile Asp Cys Asp Ile Val Arg Val 1475 1480 1485His Pro Asp Ser Ser
Leu Ala Gly Arg Lys Gly Tyr Ser Thr Thr 1490 1495 1500Glu Gly Ala
Leu Tyr Ser Tyr Leu Glu Gly Thr Arg Phe His Gln 1505 1510 1515Thr
Ala Val Asp Met Ala Glu Ile His Thr Met Trp Pro Lys Gln 1520 1525
1530Thr Glu Ala Asn Glu Gln Val Cys Leu Tyr Ala Leu Gly Glu Ser
1535 1540 1545Ile Glu Ser Ile Arg Gln Lys Cys Pro Val Asp Asp Ala
Asp Ala 1550 1555 1560Ser Ser Pro Pro Lys Thr Val Pro Cys Leu Cys
Arg Tyr Ala Met 1565 1570 1575Thr Pro Glu Arg Val Thr Arg Leu Arg
Met Asn His Val Thr Ser 1580 1585 1590Ile Ile Val Cys Ser Ser Phe
Pro Leu Pro Lys Tyr Lys Ile Glu 1595 1600 1605Gly Val Gln Lys Val
Lys Cys Ser Lys Val Met Leu Phe Asp His 1610 1615 1620Asn Val Pro
Ser Arg Val Ser Pro Arg Glu Tyr Arg Ser Ser Gln 1625 1630 1635Glu
Ser Ala Gln Glu Ala Ser Thr Ile Thr Ser Leu Thr His Ser 1640 1645
1650Gln Phe Asp Leu Ser Val Asp Gly Glu Ile Leu Pro Val Pro Ser
1655 1660 1665Asp Leu Asp Ala Asp Ala Pro Ala Leu Glu Pro Ala Leu
Asp Asp 1670 1675 1680Gly Ala Thr His Thr Leu Pro Ser Thr Thr Gly
Asn Leu Ala Ala 1685 1690 1695Val Ser Asp Trp Val Met Ser Thr Val
Pro Val Ala Pro Pro Arg 1700 1705 1710Arg Arg Arg Gly Arg Asn Leu
Thr Val Thr Cys Asp Glu Arg Glu 1715 1720 1725Gly Asn Ile Thr Pro
Met Ala Ser Val Arg Phe Phe Arg Ala Glu 1730 1735 1740Leu Cys Pro
Val Val Gln Glu Thr Ala Glu Thr Arg Asp Thr Ala 1745 1750 1755Met
Ser Leu Gln Ala Pro Pro Ser Thr Ala Thr Glu Pro Asn His 1760 1765
1770Pro Pro Ile Ser Phe Gly Ala Ser Ser Glu Thr Phe Pro Ile Thr
1775 1780 1785Phe Gly Asp Phe Asn Glu Gly Glu Ile Glu Ser Leu Ser
Ser Glu 1790 1795 1800Leu Leu Thr Phe Gly Asp Phe Leu Pro Gly Glu
Val Asp Asp Leu 1805 1810 1815Thr Asp Ser Asp Trp Ser Thr Cys Ser
Asp Thr Asp Asp Glu Leu 1820 1825 1830Leu Asp Arg Ala Gly Gly Tyr
Ile Phe Ser Ser Asp Thr Gly Pro 1835 1840 1845Gly His Leu Gln Gln
Lys Ser Val Arg Gln Ser Val Leu Pro Val 1850 1855 1860Asn Thr Leu
Glu Glu Val His Glu Glu Lys Cys Tyr Pro Pro Lys 1865 1870 1875Leu
Asp Glu Ala Lys Glu Gln Leu Leu Leu Lys Lys Leu Gln Glu 1880 1885
1890Ser Ala Ser Met Ala Asn Arg Ser Arg Tyr Gln Ser Arg Lys Val
1895 1900 1905Glu Asn Met Lys Ala Ala Ile Ile Gln Arg Leu Lys Arg
Gly Cys 1910 1915 1920Arg Leu Tyr Leu Met Ser Glu Thr Pro Lys Val
Pro Thr Tyr Arg 1925 1930 1935Thr Thr Tyr Pro Ala Pro Val Tyr Ser
Pro Pro Ile Asn Val Arg 1940 1945 1950Leu Ser Asn Pro Glu Ser Ala
Val Ala Ala Cys Asn Glu Phe Leu 1955 1960 1965Ala Arg Asn Tyr Pro
Thr Val Ser Ser Tyr Gln Ile Thr Asp Glu 1970 1975 1980Tyr Asp Ala
Tyr Leu Asp Met Val Asp Gly Ser Glu Ser Cys Leu 1985 1990 1995Asp
Arg Ala Thr Phe Asn Pro Ser Lys Leu Arg Ser Tyr Pro Lys 2000 2005
2010Gln His Ala Tyr His Ala Pro Ser Ile Arg Ser Ala Val Pro Ser
2015 2020 2025Pro Phe Gln Asn Thr Leu Gln Asn Val Leu Ala Ala Ala
Thr Lys 2030 2035 2040Arg Asn Cys Asn Val Thr Gln Met Arg Glu Leu
Pro Thr Leu Asp 2045 2050 2055Ser Ala Val Phe Asn Val Glu Cys Phe
Lys Lys Phe Ala Cys Asn 2060 2065 2070Gln Glu Tyr Trp Glu Glu Phe
Ala Ala Ser Pro Ile Arg Ile Thr 2075 2080 2085Thr Glu Asn Leu Ala
Thr Tyr Val Thr Lys Leu Lys Gly Pro Lys 2090 2095 2100Ala Ala Ala
Leu Phe Ala Lys Thr His Asn Leu Leu Pro Leu Gln 2105 2110 2115Glu
Val Pro Met Asp Arg Phe Thr Val Asp Met Lys Arg Asp Val 2120 2125
2130Lys Val Thr Pro Gly Thr Lys His Thr Glu Glu Arg Pro Lys Val
2135 2140 2145Gln Val Ile Gln Ala Ala Glu Pro Leu Ala Thr Ala Tyr
Leu Cys 2150 2155 2160Gly Ile His Arg Glu Leu Val Arg Arg Leu Asn
Ala Val Leu Leu 2165 2170 2175Pro Asn Val His Thr Leu Phe Asp Met
Ser Ala Glu Asp Phe Asp 2180 2185 2190Ala Ile Ile Ala Ala His Phe
Lys Pro Gly Asp Thr Val Leu Glu 2195 2200 2205Thr Asp Ile Ala Ser
Phe Asp Lys Ser Gln Asp Asp Ser Leu Ala 2210 2215 2220Leu Thr Ala
Leu Met Leu Leu Glu Asp Leu Gly Val Asp His Ser 2225 2230 2235Leu
Leu Asp Leu Ile Glu Ala Ala Phe Gly Glu Ile Ser Ser Cys 2240 2245
2250His Leu Pro Thr Gly Thr Arg Phe Lys Phe Gly Ala Met Met Lys
2255 2260 2265Ser Gly Met Phe Leu Thr Leu Phe Val Asn Thr Leu Leu
Asn Ile 2270 2275 2280Thr Ile Ala Ser Arg Val Leu Glu Asp Arg Leu
Thr Lys Ser Ala 2285 2290 2295Cys Ala Ala Phe Ile Gly Asp Asp Asn
Ile Ile His Gly Val Val 2300 2305 2310Ser Asp Glu Leu Met Ala Ala
Arg Cys Ala Thr Trp Met Asn Met 2315 2320 2325Glu Val Lys Ile Ile
Asp Ala Val Val Ser Leu Lys Ala Pro Tyr 2330 2335 2340Phe Cys Gly
Gly Phe Ile Leu His Asp Thr Val Thr Gly Thr Ala 2345 2350 2355Cys
Arg Val Ala Asp Pro Leu Lys Arg Leu Phe Lys Leu Gly Lys 2360 2365
2370Pro Leu Ala Ala Gly Asp Glu Gln Asp Glu Asp Arg Arg Arg Ala
2375 2380 2385Leu Ala Asp Glu Val Ile Arg Trp Gln Arg Thr Gly Leu
Ile Asp 2390 2395 2400Glu Leu Glu Lys Ala Val Tyr Ser Arg Tyr Glu
Val Gln Gly Ile 2405 2410 2415Ser Val Val Val Met Ser Met Ala Thr
Phe Ala Ser Ser Arg Ser 2420 2425 2430Asn Phe Glu Lys Leu Arg Gly
Pro Val Ile Thr Leu Tyr Gly Gly 2435 2440 2445Pro Lys
24507943DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 79aaaaaagatc tgacaacttc aatgtctata aagccacaag acc
438046DNAArtificial SequenceDescription of Artificial Sequence
Synthetic primer 80tttttgcggc cgcgtcatag tagggtacag ctcataatag
tacaag 468163DNAChikungunya virusCDS(13)..(63) 81cgcagcacca ag gac
aac ttc aat gtc tat aaa gcc aca aga cca tac cta 51 Asp Asn Phe
Asn
Val Tyr Lys Ala Thr Arg Pro Tyr Leu 1 5 10gct cac tgt cca 63Ala His
Cys Pro 158263DNAChikungunya virusCDS(1)..(63) 82ccg cat gag ata
atc ttg tac tat tat gag ctg tac cct act atg act 48Pro His Glu Ile
Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr1 5 10 15gta gta gtt
gtg tca 63Val Val Val Val Ser 208317PRTChikungunya virus 83Asp Asn
Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala His Cys1 5 10
15Pro8421PRTChikungunya virus 84Pro His Glu Ile Ile Leu Tyr Tyr Tyr
Glu Leu Tyr Pro Thr Met Thr1 5 10 15Val Val Val Val Ser
20851161DNAChikungunya virusCDS(13)..(1155) 85ggatccgcca cc atg ctg
ctg agc gtg ccc ctg ctg ctg ggc ctg ctg ggc 51 Met Leu Leu Ser Val
Pro Leu Leu Leu Gly Leu Leu Gly 1 5 10ctg gcc gtg gac aac ttc aac
gtg tac aag gct acc aga ccc tac ctg 99Leu Ala Val Asp Asn Phe Asn
Val Tyr Lys Ala Thr Arg Pro Tyr Leu 15 20 25gcc cac tgc ccc gac tgc
ggc gag gga cac agc tgc cac agc ccc gtg 147Ala His Cys Pro Asp Cys
Gly Glu Gly His Ser Cys His Ser Pro Val30 35 40 45gcc ctg gag aga
atc cgg aac gag gct acc gac ggc acc ctg aag atc 195Ala Leu Glu Arg
Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile 50 55 60cag gtg agc
ctg cag atc ggc atc aag acc gac gac agc cac gac tgg 243Gln Val Ser
Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser His Asp Trp 65 70 75acc aag
ctg aga tac atg gac aac cac atg ccc gcc gac gcc gag aga 291Thr Lys
Leu Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala Glu Arg 80 85 90gcc
ggc ctg ttc gtg aga acc agc gcc ccc tgc acc atc acc ggc acc 339Ala
Gly Leu Phe Val Arg Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr 95 100
105atg ggc cac ttc atc ctg gcc aga tgc ccc aag ggc gag acc ctg acc
387Met Gly His Phe Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu
Thr110 115 120 125gtg ggc ttc acc gac agc aga aag atc agc cac agc
tgc acc cac ccc 435Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His Ser
Cys Thr His Pro 130 135 140ttc cac cac gac cct ccc gtg atc ggc aga
gag aag ttc cac agc aga 483Phe His His Asp Pro Pro Val Ile Gly Arg
Glu Lys Phe His Ser Arg 145 150 155ccc cag cac ggc aag gag ctg ccc
tgc agc acc tac gtg cag agc acc 531Pro Gln His Gly Lys Glu Leu Pro
Cys Ser Thr Tyr Val Gln Ser Thr 160 165 170gcc gct aca acc gag gag
atc gag gtg cac atg ccc ccc gac acc ccc 579Ala Ala Thr Thr Glu Glu
Ile Glu Val His Met Pro Pro Asp Thr Pro 175 180 185gac aga acc ctg
atg agc cag cag agc ggc aac gtg aag atc acc gtg 627Asp Arg Thr Leu
Met Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val190 195 200 205aac
ggc cag acc gtg aga tac aag tgc aac tgc ggc ggc agc aac gag 675Asn
Gly Gln Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu 210 215
220ggc ctg acc aca acc gac aag gtg atc aac aac tgc aag gtg gac cag
723Gly Leu Thr Thr Thr Asp Lys Val Ile Asn Asn Cys Lys Val Asp Gln
225 230 235tgc cac gcc gcc gtg acc aac cac aag aag tgg cag tac aac
agc ccc 771Cys His Ala Ala Val Thr Asn His Lys Lys Trp Gln Tyr Asn
Ser Pro 240 245 250ctg gtg ccc aga aac gcc gag ctg ggc gac aga aag
ggc aag atc cac 819Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg Lys
Gly Lys Ile His 255 260 265atc ccc ttc ccc ctg gcc aac gtg acc tgc
aga gtg ccc aag gcc aga 867Ile Pro Phe Pro Leu Ala Asn Val Thr Cys
Arg Val Pro Lys Ala Arg270 275 280 285aac ccc acc gtg acc tac ggc
aag aac cag gtg atc atg ctg ctg tac 915Asn Pro Thr Val Thr Tyr Gly
Lys Asn Gln Val Ile Met Leu Leu Tyr 290 295 300ccc gat cac ccc acc
ctg ctg agc tac aga aac atg ggc gag gag ccc 963Pro Asp His Pro Thr
Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro 305 310 315aac tac cag
gag gag tgg gtg atg cac aag aag gag gtg gtg ctg acc 1011Asn Tyr Gln
Glu Glu Trp Val Met His Lys Lys Glu Val Val Leu Thr 320 325 330gtg
ccc acc gag ggc ctg gag gtg acc tgg ggc aac aac gag ccc tac 1059Val
Pro Thr Glu Gly Leu Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr 335 340
345aag tac tgg ccc cag ctg agc acc aac ggc acc gcc cac gga cac ccc
1107Lys Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr Ala His Gly His
Pro350 355 360 365cac gag atc atc ctg tac tac tac gag ctg tac ccc
acc atg acc tga 1155His Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro
Thr Met Thr 370 375 380ctcgag 116186380PRTChikungunya virus 86Met
Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val1 5 10
15Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala His Cys
20 25 30Pro Asp Cys Gly Glu Gly His Ser Cys His Ser Pro Val Ala Leu
Glu 35 40 45Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile Gln
Val Ser 50 55 60Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser His Asp Trp
Thr Lys Leu65 70 75 80Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala
Glu Arg Ala Gly Leu 85 90 95Phe Val Arg Thr Ser Ala Pro Cys Thr Ile
Thr Gly Thr Met Gly His 100 105 110Phe Ile Leu Ala Arg Cys Pro Lys
Gly Glu Thr Leu Thr Val Gly Phe 115 120 125Thr Asp Ser Arg Lys Ile
Ser His Ser Cys Thr His Pro Phe His His 130 135 140Asp Pro Pro Val
Ile Gly Arg Glu Lys Phe His Ser Arg Pro Gln His145 150 155 160Gly
Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr Ala Ala Thr 165 170
175Thr Glu Glu Ile Glu Val His Met Pro Pro Asp Thr Pro Asp Arg Thr
180 185 190Leu Met Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val Asn
Gly Gln 195 200 205Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn
Glu Gly Leu Thr 210 215 220Thr Thr Asp Lys Val Ile Asn Asn Cys Lys
Val Asp Gln Cys His Ala225 230 235 240Ala Val Thr Asn His Lys Lys
Trp Gln Tyr Asn Ser Pro Leu Val Pro 245 250 255Arg Asn Ala Glu Leu
Gly Asp Arg Lys Gly Lys Ile His Ile Pro Phe 260 265 270Pro Leu Ala
Asn Val Thr Cys Arg Val Pro Lys Ala Arg Asn Pro Thr 275 280 285Val
Thr Tyr Gly Lys Asn Gln Val Ile Met Leu Leu Tyr Pro Asp His 290 295
300Pro Thr Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro Asn Tyr
Gln305 310 315 320Glu Glu Trp Val Met His Lys Lys Glu Val Val Leu
Thr Val Pro Thr 325 330 335Glu Gly Leu Glu Val Thr Trp Gly Asn Asn
Glu Pro Tyr Lys Tyr Trp 340 345 350Pro Gln Leu Ser Thr Asn Gly Thr
Ala His Gly His Pro His Glu Ile 355 360 365Ile Leu Tyr Tyr Tyr Glu
Leu Tyr Pro Thr Met Thr 370 375 3808759DNAChikungunya virus
87tatagatcaa agggctacgc aacccctgaa tagtaacaaa atacaaaatc actaaaaat
598860DNAChikungunya virus 88tatagatcaa agggccgaat aacccctgaa
tagtaacaaa atatgaaaat caataaaaat 608959DNAChikungunya virus
89agtagttcaa agggctataa aacccctgaa tagtaacaaa acataaaatt aataaaaat
599059DNAChikungunya virus 90tctagatcaa agggctatat aacccctgaa
tagtaacaaa atacaaaatc actaaaaat 599160DNAChikungunya virus
91tatagatcaa agggccgaac aacccctgaa tagtaacaaa atataaaaat taataaaaat
609260DNAChikungunya virus 92agtagttcaa agggctataa aaacccctga
atagtaacaa aacataaaac taataaaaat 609360DNAChikungunya virus
93attagatcaa agggctatac aacccctgaa tagtaacaaa acacaaaaac caataaaaat
609460DNAChikungunya virus 94tatagatcaa agggctatat taacccctga
atagtaacaa aacacaaaaa caataaaaac 609560DNAChikungunya virus
95agtagttcaa agggctacaa aacccctgaa tagtaacaaa acataaaatg taataaaaat
609660DNAChikungunya virus 96agtagttcaa agggctataa aaacccctga
atagtaacaa aacataaaac taataaaaat 609760DNAChikungunya virus
97tatagatcaa aggcttgaat aacccctgaa taataataaa atataaaaat aaataagaat
609859DNAChikungunya virus 98agatgttcaa agtggctata aaaccctgaa
tagtaataaa acataaaatt aataaggat 599959DNAChikungunya virus
99tgtagatcaa agggctatat aacccctgaa tagtaacaaa atacaaaatc actaaaaat
5910061DNAChikungunya virus 100agtagttcaa agggctataa aaacccctga
atagtaacaa aacataaaac ctaataaaga 60t 6110160DNAChikungunya virus
101agatgttcaa agtggctata aaacccctga atagtaataa aacataaaat
taataaggat 6010226RNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotide 102uaagucccca acgcaucggg aaacua
2610360DNAChikungunya virus 103ccgcatgaga taatcttgta ctattatgag
ctgtacccta ctatgacgcg gccgcaaaaa 60
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