U.S. patent application number 12/504604 was filed with the patent office on 2010-01-28 for compounds exhibiting thrombopoietin receptor agonism.
This patent application is currently assigned to Shionogi & Co., Ltd.. Invention is credited to Takeshi SHIOTA, Masami TAKAYAMA, Hiroshi TAKEMOTO.
Application Number | 20100022542 12/504604 |
Document ID | / |
Family ID | 26583969 |
Filed Date | 2010-01-28 |
United States Patent
Application |
20100022542 |
Kind Code |
A1 |
TAKEMOTO; Hiroshi ; et
al. |
January 28, 2010 |
COMPOUNDS EXHIBITING THROMBOPOIETIN RECEPTOR AGONISM
Abstract
Pharmaceutical compositions containing as an active ingredient
compounds of the general formula (I), prodrugs of the same,
pharmaceutically acceptable salts of both, or solvates of them and
exhibiting thrombopoietin receptor agonism:
X.sup.1--Y.sup.1-Z.sup.1-W.sup.1 (I) wherein X.sup.1 is optionally
substituted aryl, optionally substituted heteroaryl or the like;
Y.sup.1 is --NR.sup.ACO--(CH.sub.2).sub.0-2-- or the like (wherein
R.sup.A is a hydrogen or the like); Z.sup.1 is optionally
substituted phenylene or the like; and W.sup.1 is a group
represented by the below formula: ##STR00001## wherein R.sup.1,
R.sup.2, R.sup.3, and R.sup.4 are each independently a hydrogen
atom, optionally substituted lower alkyl or the like, a broken line
(---) represents the presence or absence of bond.
Inventors: |
TAKEMOTO; Hiroshi; (Osaka,
JP) ; SHIOTA; Takeshi; (Osaka, JP) ; TAKAYAMA;
Masami; (Osaka, JP) |
Correspondence
Address: |
FINNEGAN, HENDERSON, FARABOW, GARRETT & DUNNER;LLP
901 NEW YORK AVENUE, NW
WASHINGTON
DC
20001-4413
US
|
Assignee: |
Shionogi & Co., Ltd.
|
Family ID: |
26583969 |
Appl. No.: |
12/504604 |
Filed: |
July 16, 2009 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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10169362 |
Jul 2, 2002 |
7582665 |
|
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PCT/JP01/00411 |
Jan 23, 2001 |
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12504604 |
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Current U.S.
Class: |
514/236.8 ;
514/342; 514/371; 544/133; 546/270.7; 548/195 |
Current CPC
Class: |
C07D 333/38 20130101;
C07D 231/40 20130101; A61K 31/426 20130101; A61K 31/427 20130101;
C07D 277/46 20130101; A61K 31/5377 20130101; C07D 249/14 20130101;
C07D 417/04 20130101; A61K 31/4439 20130101; C07D 285/18 20130101;
C07D 417/14 20130101; C07D 277/82 20130101; C07D 285/16
20130101 |
Class at
Publication: |
514/236.8 ;
548/195; 514/371; 546/270.7; 514/342; 544/133 |
International
Class: |
A61K 31/5377 20060101
A61K031/5377; C07D 277/00 20060101 C07D277/00; A61K 31/425 20060101
A61K031/425; C07D 417/02 20060101 C07D417/02; A61K 31/4439 20060101
A61K031/4439; A61P 7/02 20060101 A61P007/02 |
Foreign Application Data
Date |
Code |
Application Number |
Jan 24, 2000 |
JP |
2000-13770 |
Feb 8, 2000 |
JP |
2000-30593 |
Claims
1. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism which contains as an active ingredient a compound of the
general formula (I): X.sup.1--Y.sup.1-Z.sup.1-W.sup.1 (I) wherein
X.sup.1 is optionally substituted aryl, optionally substituted
aralkyl, optionally substituted heteroaryl, or optionally
substituted heteroarylalkyl; Y.sup.1 is
--NR.sup.ACO--(CR.sup.CR.sup.D).sub.0-2--,
--NR.sup.ACO--(CH.sub.2).sub.0-2--V--,
--NR.sup.ACR.sup.C.dbd.CR.sup.D--,
--V--(CH.sub.2).sub.1-5--NR.sup.ACO--(CH.sub.2).sub.0-2--,
--V--(CH.sub.2).sub.1-5--CONR.sup.A--(CH.sub.2).sub.0-2--,
--CONR.sup.A--(CH.sub.2).sub.0-2--,
--(CH.sub.2).sub.0-2--NR.sup.A--SO.sub.2--(CH.sub.2).sub.0-2--,
--(CH.sub.2).sub.0-2--, SO.sub.2--NR.sup.A--(CH.sub.2).sub.0-2--,
--NR.sup.A--(CH.sub.2).sub.0-2, --NR.sup.A--CO--NR.sup.A--,
--NR.sup.A--CS--NR.sup.A--, --N.dbd.C(--SR.sup.A)--NR.sup.A,
--NR.sup.ACSNR.sup.ACO--, --N.dbd.C(--SR.sup.A)--NR.sup.ACO--,
--NR.sup.A--(CH.sub.2).sub.1-2--NR.sup.A--CO--,
--NR.sup.ACONR.sup.ANR.sup.BCO--, or
--N.dbd.C(--NR.sup.AR.sup.A)--NR.sup.A--CO--, wherein R.sup.A is
each independently a hydrogen atom or lower alkyl; R.sup.B is a
hydrogen atom or phenyl; R.sup.C and R.sup.D are each independently
a hydrogen atom, halogen atom, optionally substituted lower alkyl,
optionally substituted lower alkyloxy, optionally substituted lower
alkylthio, optionally substituted lower alkenyl, optionally
substituted lower alkynyl, optionally substituted aryl, optionally
substituted heteroaryl, optionally substituted cycloalkyl,
optionally substituted aralkyl, optionally substituted
heteroarylalkyl, optionally substituted non-aromatic heterocyclic
group, or optionally substituted amino; V is an oxygen atom or a
sulfur atom; Z.sup.1 is optionally substituted phenylene,
optionally substituted monocyclic heteroarylene, optionally
substituted monocyclic non-aromatic heterocycle-diyl, or optionally
substituted monocyclic cycloalkane-diyl; W.sup.1 is a group
represented by the formula: ##STR00305## wherein R.sup.1, R.sup.2,
R.sup.3, R.sup.4, R.sup.7, and R.sup.8 are each independently a
hydrogen atom, halogen atom, optionally substituted lower alkyl,
optionally substituted lower alkyloxy, optionally substituted lower
alkylthio, optionally substituted lower alkenyl, optionally
substituted lower alkynyl, optionally substituted aryl, optionally
substituted heteroaryl, optionally substituted cycloalkyl,
optionally substituted aralkyl, optionally substituted
heteroarylalkyl, optionally substituted nonaromatic heterocyclic
group, or optionally substituted amino; R.sup.5, R.sup.6, and
R.sup.9 are each independently a hydrogen atom, optionally
substituted lower alkyl, optionally substituted lower alkenyl,
optionally substituted lower alkynyl, optionally substituted aryl,
optionally substituted heteroaryl, optionally substituted
cycloalkyl, optionally substituted aralkyl, optionally substituted
heteroarylalkyl, or optionally substituted non-aromatic
heterocyclic group; A.sup.1 is a optionally substituted aryl or
optionally substituted heteroaryl; a broken line (---) represents
the presence or absence of a bond, its prodrug, or pharmaceutically
acceptable salts or solvates thereof.
2. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of claim 1, wherein X.sup.1 is optionally substituted
heteroaryl.
3. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of claim 1, wherein X.sup.1 is a group represented by the
formula: ##STR00306## wherein R.sup.10 and R.sup.11 are each
independently a hydrogen atom, optionally substituted lower alkyl,
carboxy, lower alkyloxycarbonyl, halogen atom, optionally
substituted aminocarbonyl, optionally substituted heteroaryl, or
optionally substituted aryl; R.sup.12 is a hydrogen atom or lower
alkyl.
4. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism which contains a compound of claim 1, wherein X.sup.1 is a
group represented by the formula: ##STR00307##
5. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of claims 1 to 4, wherein Y.sup.1 is --NHCO--,
--CONH--, --NHCH.sub.2--, --NHCO--CH.dbd.CH--, or
--NHSO.sub.2--.
6. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of claims 1 to 4, wherein Y.sup.1 is
--NHCO--.
7. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of claims 1 to 4, wherein Z.sup.1 is
1,4-phenylene optionally substituted with halogen atom or lower
alkyl.
8. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of claims 1 to 4, wherein R.sup.1 is a hydrogen
atom or lower alkyl.
9. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of claims 1 to 4, wherein R.sup.2 is a hydrogen
atom, lower alkyl, halogen atom, lower alkyloxy, lower alkylthio,
or optionally substituted amino.
10. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of claims 1 to 4, wherein W.sup.1 is a group
represented by the formula: ##STR00308## wherein R.sup.13 is a
hydrogen atom, lower alkyl, lower alkyloxy, lower alkylthio, or
halogen atom; R.sup.14 and R.sup.15 are each independently a
hydrogen atom, or optionally substituted lower alkyl, optionally
substituted lower alkenyl, optionally substituted lower alkynyl,
optionally substituted cycloalkyl, optionally substituted aryl,
optionally substituted heteroaryl, or optionally substituted
heteroarylalkyl, each substituted by one or more substituent(s)
selected from substituent group A; a broken line (---) represents
the presence or absence of a bond; substituent group A consists of
a halogen atom, halo(lower)alkyl, optionally substituted amino,
carboxy, lower alkylthio, lower alkylsilyl, or lower alkyloxy.
11. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of claims 1 to 4, wherein W.sup.1 is a group
represented by the formula: ##STR00309## R.sup.13 is a hydrogen
atom, lower alkyl, lower alkyloxy, lower alkylthio, or halogen
atom; R.sup.26 is a hydrogen atom or lower alkyl; a broken line
(---) represents the presence or absence of a bond;
12. A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of claims 1 to 4, which is a platelet production
modifier.
13. A pharmaceutical composition for platelet production
modification, comprising at least one compound according to claim 1
and at least one of an excipient, binder, penetrant, disintegrator,
or lubricant.
14. A method for modifying a platelet production of a mammal,
including a human, which comprises administration to said mammal of
a compound of any one of claims 1 to 4 in a pharmaceutically
effective amount.
15. A compound represented by the general formula (II):
X.sup.2--Y.sup.2-Z.sup.2-W.sup.2 (II) wherein X.sup.2 is optionally
substituted 5-member heteroaryl or optionally substituted pyridyl:
Y.sup.2 is --NR.sup.ACO--(CR.sup.CR.sup.D).sub.0-2--,
--NR.sup.ACO--(CH.sub.2).sub.0-2--V--,
--NR.sup.ACO--CR.sup.C.dbd.CR.sup.D--,
--V--(CH.sub.2).sub.1-5--NR.sup.ACO--(CH.sub.2).sub.0-2--,
--V--(CH.sub.2).sub.1-5--CONR.sup.A--(CH.sub.2).sub.0-2--,
--CONR.sup.A--(CH.sub.2).sub.0-2,
--(CH.sub.2).sub.0-2--NR.sup.ASO.sub.2--(CH.sub.2).sub.0-2--,
--(CH.sub.2).sub.0-2--SO.sub.2--NR.sup.A--(CH.sub.2).sub.0-2--,
--NR.sup.A--(CH.sub.2).sub.0-2--, --NR.sup.A--CO--NR.sup.A--,
--NR.sup.A--CS--NR.sup.A--, --N.dbd.C(--SR.sup.A)--NR.sup.A--,
--NR.sup.ACSNR.sup.A--CO--, --N.dbd.C(--SR.sup.A)--NR.sup.ACO--,
--NR.sup.A--(CH.sub.2).sub.1-2--NR.sup.A--CO--,
--NR.sup.ACONR.sup.ANR.sup.B--CO--, or
--N.dbd.C(--NR.sup.AR.sup.A)--NR.sup.A--CO--, wherein R.sup.A is
each independently a hydrogen atom or lower alkyl; R.sup.B is a
hydrogen atom or phenyl; R.sup.C and R.sup.D are each independently
a hydrogen atom, halogen atom, optionally substituted lower alkyl,
optionally substituted lower alkyloxy, optionally substituted lower
alkylthio, optionally substituted lower alkenyl, optionally
substituted lower alkynyl, optionally substituted aryl, optionally
substituted heteroaryl, optionally substituted cycloalkyl,
optionally substituted aralkyl, optionally substituted
heteroaryl-alkyl, optionally substituted non-aromatic heterocyclic
group, or optionally substituted amino; V is an oxygen atom or a
sulfur atom; Z.sup.2 is optionally substituted phenylene,
optionally substituted 2,5-pyridine-diyl, optionally substituted
2,5-thiophene-diyl, or optionally substituted 2,5-furan-diyl;
W.sup.2 is a group represented by the formula: ##STR00310## wherein
R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.7, and R.sup.8 are each
independently a hydrogen atom, halogen atom, optionally substituted
lower alkyl, optionally substituted lower alkyloxy, optionally
substituted lower alkylthio, optionally substituted lower alkenyl,
optionally substituted lower alkynyl, optionally substituted aryl,
optionally substituted heteroaryl, optionally substituted
cycloalkyl, optionally substituted aralkyl, optionally substituted
heteroarylalkyl, optionally substituted nonaromaticheterocyclic
group, or optionally substituted amino; R.sup.5, R.sup.6, and
R.sup.9 are each independently a hydrogen atom, optionally
substituted lower alkyl, optionally substituted lower alkenyl,
optionally substituted lower alkynyl, optionally substituted aryl,
optionally substituted heteroaryl, optionally substituted
cycloalkyl, optionally substituted aralkyl, optionally substituted
heteroarylalkyl, or optionally substituted non-aromatic
heterocyclic group; A.sup.2 is a optionally substituted aryl or
optionally substituted heteroaryl; a broken line (---) represents
the presence or absence of a bond, its prodrug, or pharmaceutically
acceptable salts or solvates thereof.
16. A compound of claim 15, wherein X.sup.2 is a group represented
by the formula: ##STR00311## wherein R.sup.10 and R.sup.11 are each
independently a hydrogen atom, optionally substituted lower alkyl,
carboxy, lower alkyloxycarbonyl, halogen atom, optionally
substituted aminocarbonyl, optionally substituted heteroaryl, or
optionally substituted aryl, its prodrug, or pharmaceutically
acceptable salts or solvates thereof.
17. A compound in of claim 15 or 16, wherein X.sup.2 is a group
represented by the formula: ##STR00312## wherein R.sup.16 is a
hydrogen atom, optionally substituted lower alkyl, carboxy, lower
alkyloxycarbonyl, halogen atom, or optionally substituted amino
carbonyl; R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21,
R.sup.22, and R.sup.23 are each independently a hydrogen atom,
optionally substituted lower alkyl by one or more substituent(s)
selected from substituent group B, cycloalkyl, optionally
substituted alkyoxy by one or more substituent(s) selected from
substituent group B, alkylthio, halogen atom, optionally
substituted phenyl by one or more substituent(s) selected from
substituent group C, optionally substituted heteroaryl by one or
more substituent(s) selected from substituent group C, or
optionally substituted nonaromatic heterocyclic group by one or
more substituent(s) selected from substituent group C; substituent
group B consists of hydroxy, alkyloxy, halogen atom, carboxy, lower
alkyloxycarbonyl, aryloxycarbonyl, optionally substituted amino,
optionally substituted phenyl by one or more substituent(s)
selected from substituent group C, non-aromatic heterocyclic group,
or heteroaryl; substituent group C consists of hydroxy, alkyl,
halogen atom, halo(lower)alkyl, carboxy, lower alkyloxycarbonyl,
alkyloxy, optionally substituted amino, non-aromaticheterocyclic
group, or heteroaryl; or R.sup.16 and R.sup.17 taken together may
form --CH.sub.2--, --CH.sub.2CH.sub.2--,
--CH.sub.2CH.sub.2CH.sub.2--, --OCH.sub.2--, or --SCH.sub.2--; its
prodrug, or pharmaceutically acceptable salts or solvates
thereof.
18. A compound of any one of claims 15 or 16, wherein Y.sup.2 is
--NHCO--; its prodrug, or pharmaceutically acceptable salts or
solvates thereof.
19. A compound of any one of claims 15 or 16, wherein Z.sup.2 is
1,4-phenylene optionally substituted with halogen atom or lower
alkyl; its prodrug, or pharmaceutically acceptable salts or
solvates thereof.
20. A compound of any one of claims 15 or 16, wherein R.sup.1 is a
hydrogen atom or lower alkyl; its prodrug, or pharmaceutically
acceptable salts or solvates thereof.
21. A compound of any one of claims 15 or 16, wherein R.sup.2 is a
hydrogen atom, lower alkyl, halogen atom, lower alkyloxy, lower
alkylthio, or optionally substituted amino; its prodrug, or their
pharmaceutically acceptable salts or solvates thereof.
22. A compound of any one of claims 15 or 16, wherein W.sup.2 is a
group represented by the formula: ##STR00313## wherein, R.sup.1,
R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and
A.sup.2 are as defined in claim 15; provided that R.sup.2 is not
imidazolyl, triazolyl, or tetrazolyl; its prodrug, or
pharmaceutically acceptable salts or solvates thereof.
23. A compound of any one of claims 15 or 16, wherein W.sup.2 is a
group represented by the formula: ##STR00314## wherein R.sup.13 is
a hydrogen atom, lower alkyl, lower alkyloxy, lower alkylthio, or
halogen atom; R.sup.14 and R.sup.15 are each independently a
hydrogen atom, or optionally substituted lower alkyl, optionally
substituted lower alkenyl, optionally substituted lower alkynyl,
optionally substituted cycloalkyl, optionally substituted aryl,
optionally substituted heteroaryl, or optionally substituted
heteroarylalkyl, each substituted by one or more substituent(s)
selected from substituent group A; substituent group A consists of
a halogen atom, halo(lower)alkyl, optionally substituted amino,
carboxy, lower alkylthio, lower alkylsilyl, or lower alkyloxy; its
prodrug, or pharmaceutically acceptable salts or solvates
thereof.
24. A compound of any one of claims 15 or 16, wherein W2 is a group
represented by the formula: ##STR00315## wherein R.sup.13 is a
hydrogen atom, lower alkyl, lower alkyloxy, lower alkylthio, or
halogen atom; R.sup.26 is a hydrogen atom or lower alkyl; a broken
line (---) represents the presence or absence of a bond; its
prodrug, or pharmaceutically acceptable salts or solvates
thereof.
25. (canceled)
26. (canceled)
27. A compound represented by the general formula (IV-B):
##STR00316## wherein R.sup.28, R.sup.29, and R.sup.30 are each
independently a hydrogen atom, optionally substituted lower alkyl
by one or more substituent(s) selected from substituent group B,
cycloalkyl, optionally substituted alkyoxy by one or more
substituent(s) selected from substituent group B, alkylthio,
halogen atom, optionally substituted phenyl by one or more
substituent(s) selected from substituent group C, optionally
substituted heteroaryl by one or more substituent(s) selected from
substituent group C, or optionally substituted nonaromatic
heterocyclic group by one or more substituent(s) selected from
substituent group C; substituent group B consists of hydroxy,
alkyloxy, halogen atom, carboxy, lower alkyloxycarbonyl,
aryloxycarbonyl, optionally substituted amino, optionally
substituted phenyl by one or more substituent(s) selected from
substituent group C, non-aromatic heterocyclic group, or
heteroaryl; substituent group C consists of hydroxy, alkyl, halogen
atom, halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy,
optionally substituted amino, non-aromatic heterocyclic group, or
heteroaryl; R.sup.31 and R.sup.32 are each independently a hydrogen
atom, lower alkyl, halogen atom, haro(lower)alkyl, lower alkyloxy,
halo(lower)alkyloxy, or hydroxy; W4 is a group represented by the
formula: ##STR00317## wherein R.sup.13 is a hydrogen atom, lower
alkyl, lower alkyloxy, lower alkylthio, or halogen atom; R.sup.14
and R.sup.15 are each independently a hydrogen atom, optionally
substituted lower alkyl, optionally substituted lower alkenyl,
optionally substituted lower alkynyl, optionally substituted
cycloalkyl, optionally substituted aryl, optionally substituted
aralkyl, optionally substituted heteroaryl, optionally substituted
heteroarylalkyl, or optionally substituted non-aromatic
heterocyclic group, each substituted by one or more substituent(s)
selected from substituent group A; substituent group A consists of
a halogen atom, halo(lower)alkyl, optionally substituted amino,
carboxy, lower alkylthio, lower alkylsilyl, or lower alkyloxy;
R.sup.24 is a hydrogen atom or lower alkyl; T is --CH2-, --CH2CH2-,
--CH2CH2CH2-, --OCH2-, or --SCH2-; its prodrug, or pharmaceutically
acceptable salts or solvates thereof.
28. A pharmaceutical composition containing as the active
ingredient a compound of any one of claims 15 or 27.
29. A pharmaceutical composition containing as the active
ingredient a compound of any one of claims 15 or 27, which is
exhibiting thrombopoietin receptor agonism.
30. A platelet production modifier which contains as the active
ingredient a compound of any one of claims 15 or 27.
31. A pharmaceutical composition for platelet production
modification, comprising at least one compound according to any one
of claims 15 or 27 and at least one of an excipient, binder,
penetrant, disintegrator, or lubricant.
32. A method for modifying a platelet production of a mammal,
including a human, which comprises administration to said mammal of
a compound of any one of claims 15 or 27 in a pharmaceutically
effective amount.
33. A compound represented by the general formula (II):
X.sup.2--Y.sup.2-Z.sup.2-W.sup.2 (II) wherein X.sup.2 is optionally
substituted 5-membered heteroaryl or optionally substituted
pyridyl; Y.sup.2 is --NR.sup.ACO--(CR.sup.CR.sup.D).sub.0-2--,
--NR.sup.ACO--(CH.sub.2).sub.0-2--V--,
--NR.sup.ACO--CR.sup.C.dbd.CR.sup.D--,
--V--(CH.sub.2).sub.1-5--NR.sup.ACO--(CH.sub.2).sub.0-2--,
--V--(CH.sub.2).sub.1-5--CONR.sup.A--(CH.sub.2).sub.0-2--,
--CONR.sup.A--(CH.sub.2).sub.0-2,
--(CH.sub.2).sub.0-2--NR.sup.ASO.sub.2--(CH.sub.2).sub.0-2--,
--(CH.sub.2).sub.0-2--SO.sub.2--NR.sup.A--(CH.sub.2).sub.0-2--,
--NR.sup.A--(CH.sub.2).sub.0-2--, --NR.sup.A--CO--NR.sup.A--,
--NR.sup.A--CS--NR.sup.A--, --N.dbd.C(--SR.sup.A)--NR.sup.A--,
--NR.sup.ACSNR.sup.ACO--, --N.dbd.C(--SR.sup.A)--NR.sup.ACO--,
--NR.sup.A--(CH.sub.2).sub.1-2--NR.sup.A--CO--,
--NR.sup.ACONR.sup.ANR.sup.B--CO--, or
--N.dbd.C(--NR.sup.AR.sup.A)--NR.sup.A--CO--, wherein R.sup.A is
each independently a hydrogen atom or lower alkyl; R.sup.B is a
hydrogen atom or phenyl; R.sup.C and R.sup.D are each independently
a hydrogen atom, halogen atom, optionally substituted lower alkyl,
optionally substituted lower alkyloxy, optionally substituted lower
alkylthio, optionally substituted lower alkenyl, optionally
substituted lower alkynyl, optionally substituted aryl, optionally
substituted heteroaryl, optionally substituted cycloalkyl,
optionally substituted aralkyl, optionally substituted
heteroarylalkyl, optionally substituted non-aromatic heterocyclic
group, or optionally substituted amino; V is an oxygen atom or a
sulfur atom; Z.sup.2 is optionally substituted phenylene,
optionally substituted 2,5-pyridine-diyl, optionally substituted
2,5-thiophene-diyl, or optionally substituted 2,5-furan-diyl;
W.sup.2 is a group represented by the formula: ##STR00318## wherein
R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.7, and R.sup.8 are each
independently a hydrogen atom, halogen atom, optionally substituted
lower alkyl, optionally substituted lower alkyloxy, optionally
substituted lower alkylthio, optionally substituted lower alkenyl,
optionally substituted lower alkynyl, optionally substituted aryl,
optionally substituted heteroaryl, optionally substituted
cycloalkyl, optionally substituted aralkyl, optionally substituted
heteroarylalkyl, optionally substituted non-aromatic heterocyclic
group, or optionally substituted amino; R.sup.5, R.sup.6, and
R.sup.9 are each independently a hydrogen atom, optionally
substituted lower alkyl, optionally substituted lower alkenyl,
optionally substituted lower alkynyl, optionally substituted aryl,
optionally substituted heteroaryl, optionally substituted
cycloalkyl, optionally substituted aralkyl, optionally substituted
heteroarylalkyl, or optionally substituted non-aromatic
heterocyclic group; A.sup.2 is optionally substituted aryl or
optionally substituted heteroaryl; a broken line (---) represents
the presence or absence of a bond, provided that, 1) when X.sup.2
is thiazolyl optionally substituted with alkyl, or benzothiazolyl
optionally substituted with alkoxyl or diethylamino; Z.sup.2 is
1,4-phenylene; and W.sup.2 is a group represented by the formula:
##STR00319## R.sup.2 is not optionally substituted imidazolyl,
optionally substituted triazolyl, or optionally substituted
tetrazolyl, 2) when X.sup.2 is 2-pyridyl; Y.sup.2 is
--NHCO--CH.dbd.CH--, or --NHCSNHCO--; Z.sup.2 is 1,4-phenylene; and
W.sup.2 is a group represented by the formula: ##STR00320## R.sup.2
is not triazolyl, 3) when X.sup.2 is benzothiazolyl; Y.sup.2 is
--NHCO--CH.dbd.CH--; Z.sup.2 is 1,4-phenylene; and W.sup.2 is a
group represented by the formula: ##STR00321## R.sup.2 is not
2-pyridyl or carboxymethyl, 4) when X.sup.2 is benzothiazolyl;
Y.sup.2 is --NHCO--; and Z.sup.2 is 1,4-phenylene; W.sup.2 is not a
group represented by the formula: ##STR00322## 5) when X.sup.2 is
thiazolyl optionally substituted with methyl, t-butyl, or
unsubstituted phenyl, or benzothiazolyl optionally substituted with
alkyl or diethylaminoethyl; Z.sup.2 is optionally substituted
phenylene; and W.sup.2 is --CH.dbd.O, Y.sup.2 is not
--NHCO--(CH.sub.2).sub.0-2--, --NHCO--CH.dbd.CH--,
--NHCO--CH.sub.2--O--, or --NHCO--CH.sub.2--NMe-, 6) when Y.sup.2
is --NH--CH.sub.2--; Z.sup.2 is 1,4-phenylene; W.sup.2 is
optionally substituted tetrazolyl wherein 2-position is substituted
phenyl, X.sup.2 is not thiadiazolyl, thiazolyl, benzothiazolyl,
oxadiazazolyl, imidazolyl, or oxazolyl, 7) when X.sup.2 is
optionally substituted benzothiazolyl; Z.sup.2 is 1,4-phenylene;
and W.sup.2 is a group represented by the formula: ##STR00323##
Y.sup.2 is not --NHCO--, --NH--CH.sub.2--, --NEt-CH.sub.2--, or
--NH-- 8) when X.sup.2 is optionally substituted benzothiazolyl;
Y.sup.2 is --NH--; and Z.sup.2 is 1,4-phenylene; W.sup.2 is not
--CH.sub.2COOH or --CH.sub.2COOEt, 9) when X.sup.2 is optionally
substituted benzothiazolyl; Y.sup.2 is --NH--; and Z.sup.2 is
2,5-pyridinediyl; W.sup.2 is not --COOH or --CONH.sub.2, 10) when
X.sup.2 is optionally substituted benzothiazolyl; Z.sup.2 is
phenylene optionally substituted with methyl or chlorine atom; and
W.sup.2 is --COOH, --COOEt, or --CONH.sub.2, Y.sup.2 is not --NH--,
--NH--CH.sub.2--, --NH--CO--, or --NH--SO.sub.2--, its prodrug, or
pharmaceutically acceptable salts or solvates thereof.
34. A compound of claim 33 wherein X.sup.2 is represented by the
formula: ##STR00324## wherein R.sup.10 and R.sup.11 are each
independently a hydrogen atom, optionally substituted lower alkyl,
carboxy, lower alkyloxycarbonyl, halogen atom, optionally
substituted aminocarbonyl, optionally substituted heteroaryl, or
optionally substituted aryl; its prodrug, or pharmaceutically
acceptable salts or solvates thereof.
35. A compound of claim 33 or 34 wherein X.sup.2 is represented by
the formula: ##STR00325## wherein R.sup.16 is a hydrogen atom,
optionally substituted lower alkyl, carboxy, lower
alkyloxycarbonyl, halogen atom, or optionally substituted
aminocarbonyl; R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21,
R.sup.22, and R.sup.23 are each independently a hydrogen atom,
optionally substituted lower alkyl by one or more substituent(s)
selected from substituent group B, cycloalkyl, optionally
substituted alkyoxy by one or more substituent(s) selected from
substituent group B, alkylthio, halogen atom, optionally
substituted phenyl by one or more substituent(s) selected from
substituent group C, optionally substituted heteroaryl by one or
more substituent(s) selected from substituent group C, or
optionally substituted nonaromatic heterocyclic group by one or
more substituent(s) selected from substituent group C; substituent
group B consists of hydroxy, alkyloxy, halogen atom, carboxy, lower
alkyloxycarbonyl, aryloxycarbonyl, optionally substituted amino,
optionally substituted phenyl by one or more substituent(s)
selected from substituent group C, non-aromatic heterocyclic group,
and heteroaryl; substituent group C consists of hydroxy, alkyl,
halogen atom, halo(lower)alkyl, carboxy, lower alkyloxycarbonyl,
alkyloxy, optionally substituted amino, non-aromatic heterocyclic
group, and heteroaryl; or R.sup.16 and R.sup.17 taken together may
form --CH.sub.2--, --CH.sub.2CH.sub.2--,
--CH.sub.2CH.sub.2CH.sub.2--, --OCH.sub.2--, or SCH.sub.2--; its
prodrug, or pharmaceutically acceptable salts or solvates
thereof.
36. A compound of any one of claims 33 or 34, wherein Y.sup.2 is
--NHCO--; its prodrug, or pharmaceutically acceptable salts or
solvates thereof.
37. A compound of any one of claims 33 or 34, wherein Z.sup.2 is
1,4-phenylene optionally substituted with halogen atom or lower
alkyl; its prodrug, or pharmaceutically acceptable salts or
solvates thereof.
38. A compound of any one of claims 33 or 34, wherein R.sup.1 is a
hydrogen atom or lower alkyl; its prodrug, or pharmaceutically
acceptable salts or solvates thereof.
39. A compound of any one of claims 33 or 34, wherein R.sup.2 is a
hydrogen atom, lower alkyl, halogen atom, lower alkyloxy, lower
alkylthio, or optionally substituted amino; its prodrug, or
pharmaceutically acceptable salts or solvates thereof.
40. A compound of any one of claims 33 or 34, wherein W.sup.2 is a
group represented by the formula: ##STR00326## wherein R.sup.1,
R.sup.2, R.sup.3, R.sup.4, R.sup.7, and R.sup.8 are each
independently a hydrogen atom, halogen atom, optionally substituted
lower alkyl, optionally substituted lower alkyloxy, optionally
substituted lower alkylthio, optionally substituted lower alkenyl,
optionally substituted lower alkynyl, optionally substituted aryl,
optionally substituted heteroaryl, optionally substituted
cycloalkyl, optionally substituted aralkyl, optionally substituted
heteroarylalkyl, optionally substituted nonaromaticheterocyclic
group, or optionally substituted amino; R.sup.5, R.sup.6, and
R.sup.9 are each independently a hydrogen atom, optionally
substituted lower alkyl, optionally substituted lower alkenyl,
optionally substituted lower alkynyl, optionally substituted aryl,
optionally substituted heteroaryl, optionally substituted
cycloalkyl, optionally substituted aralkyl, optionally substituted
heteroarylalkyl, or optionally substituted non-aromatic
heterocyclic group; A.sup.2 is a optionally substituted aryl or
optionally substituted heteroaryl; provided that R.sup.2 is not
imidazolyl, triazolyl, or tetrazolyl; its prodrug, or
pharmaceutically acceptable salts or solvates thereof.
41. A compound of any one of claims 33 or 34, wherein W.sup.2 is a
group represented by the formula: ##STR00327## wherein R.sup.13 is
a hydrogen atom, lower alkyl, lower alkyloxy, lower alkylthio, or
halogen atom; R.sup.14 and R.sup.15 are each independently a
hydrogen atom, or optionally substituted lower alkyl, optionally
substituted lower alkenyl, optionally substituted lower alkynyl,
optionally substituted cycloalkyl, optionally substituted aryl,
optionally substituted heteroaryl, or optionally substituted
heteroarylalkyl, each substituted by one or more substituent(s)
selected from substituent group A; substituent group A consists of
a halogen atom, halo(lower)alkyl, optionally substituted amino,
carboxy, lower alkylthio, lower alkylsilyl, or lower alkyloxy; its
prodrug, or pharmaceutically acceptable salts or solvates
thereof.
42. A compound of any one of claims 33 or 34, wherein W.sup.2 is a
group represented by the formula: ##STR00328## wherein R.sup.13 is
a hydrogen atom, lower alkyl, lower alkyloxy, lower alkylthio, or
halogen atom; R.sup.26 is a hydrogen atom or lower alkyl; a broken
line (---) represents the presence or absence of a bond; its
prodrug, or pharmaceutically acceptable salts or solvates
thereof.
43. A pharmaceutical composition containing as an active ingredient
a compound of any one of claims 33 or 34.
44. A pharmaceutical composition containing as an active ingredient
a compound of any one of claims 33 or 34, which exhibits
thrombopoietin receptor agonism.
45. A composition for use as a platelet production modifier which
contains as an active ingredient a compound of any one of claims 33
or 34.
46. A pharmaceutical composition for platelet production
modification, comprising at least one compound according to claim
33 or 34 and at least one of an excipient, binder, penetrant,
disintegrator, or lubricant.
47. A method for modifying the platelet production of a mammal,
including a human, which comprises administration to said mammal of
a compound of any one of claims 33 or 34 in a pharmaceutically
effective amount.
Description
TECHNICAL FIELD
[0001] The present invention relates to compounds exhibiting
thrombopoietin receptor agonism.
BACKGROUND ART
[0002] Thrombopoietin, polypeptide cytokine composed of 332 amino
acids, activates the production of platelets by stimulating the
differentiation and proliferation of megakaryocytes through the
receptor and is expected as a medicine for hemopathy accompanied
with the unusual number of platelets, for example, thrombocytopenia
and the like. DNA sequences encoding the thrombopoietin receptor
have been described in Proc. Natl. Acad. Sci., 89, 5640-5644
(1992). Low molecular peptides having an affinity for the
thrombopoietin receptor is also known (JP98/72492A and WO96/40750),
but these peptide derivatives are not generally practical for oral
administration.
[0003] 1,4-Benzodiazepine derivatives as a low molecule compound
having an affinity to the thrombopoietin receptor is described in
JP99/1477A and JP99/152276A.
[0004] The compounds having a similar structure of the present
invention compound are described in JP98/287634A and the like, but
the affinity for thrombopoietin receptor is not described
therein.
DISCLOSURE OF INVENTION
[0005] The object of the present invention is to prepare
pharmaceutical compositions exhibiting thrombopoietin receptor
agonism and provide orally administrate platelet production
modifiers.
[0006] In the above situation, the inventors of the present
invention have found that the following compounds exhibit strong
thrombopoietin receptor agonism.
[0007] The present invention relates to:
I) A pharmaceutical composition exhibiting thrombopoietin receptor
agonism which contains as an active ingredient a compound of the
general formula (I):
X.sup.1--Y.sup.1-Z.sup.1-W.sup.1 (I)
wherein X.sup.1 is optionally substituted aryl, optionally
substituted aralkyl, optionally substituted heteroaryl, or
optionally substituted heteroarylalkyl; Y.sup.1 is
--NR.sup.ACO--(CR.sup.CR.sup.D).sub.0-2--,
--NR.sup.ACO--(CH.sub.2).sub.0-2--V--,
--NR.sup.ACR.sup.C.dbd.CR.sup.D--,
--V--(CH.sub.2).sub.1-5--NR.sup.ACO--(CH.sub.2).sub.0-3--,
--V--(CH.sub.2).sub.1-5CONR.sup.A--(CH.sub.2).sub.0-2--,
--CONR.sup.A--(CH.sub.2).sub.0-2--,
--(CH.sub.2).sub.0-2--NR.sup.A--SO.sub.2--(CH.sub.2).sub.0-2--,
--(CH.sub.2).sub.0-2--, SO.sub.2--NR.sup.A--(CH.sub.2).sub.0-2--,
--NR.sup.A--(CH.sub.2).sub.0-2, --NR.sup.A--CO--NR.sup.A--,
--NR.sup.A--CS--NR.sup.A--, --N.dbd.C(--SR.sup.A)--NR.sup.A,
--NR.sup.ACSNR.sup.ACO--, --N.dbd.C(--SR.sup.A)--NR.sup.ACO--,
--NR.sup.A--(CH.sub.2).sub.1-2--NR.sup.A--CO--,
--NR.sup.ACONR.sup.ANR.sup.BCO--, or
--N.dbd.C(--NR.sup.AR.sup.A)--NR.sup.A--CO--, wherein R.sup.A is
each independently a hydrogen atom or lower alkyl; R.sup.B is a
hydrogen atom or phenyl; R.sup.C and R.sup.D are each independently
a hydrogen atom, halogen atom, optionally substituted lower alkyl,
optionally substituted lower alkyloxy, optionally substituted lower
alkylthio, optionally substituted lower alkenyl, optionally
substituted lower alkynyl, optionally substituted aryl, optionally
substituted heteroaryl, optionally substituted cycloalkyl,
optionally substituted aralkyl, optionally substituted
heteroarylalkyl, optionally substituted non-aromatic heterocyclic
group, or optionally substituted amino; V is an oxygen atom or a
sulfur atom;
[0008] Z.sup.1 is optionally substituted phenylene, optionally
substituted monocyclic heteroarylene, optionally substituted
monocyclic non-aromatic heterocycle-diyl, or optionally substituted
monocyclic cycloalkane-diyl;
[0009] W.sup.1 is a group represented by the formula:
##STR00002##
wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.7, and R.sup.8
are each independently a hydrogen atom, halogen atom, optionally
substituted lower alkyl, optionally substituted lower alkyloxy,
optionally substituted lower alkylthio, optionally substituted
lower alkenyl, optionally substituted lower alkynyl, optionally
substituted aryl, optionally substituted heteroaryl, optionally
substituted cycloalkyl, optionally substituted aralkyl, optionally
substituted heteroarylalkyl, optionally substituted non-aromatic
heterocyclic group, or optionally substituted amino;
[0010] R.sup.5, R.sup.6, and R.sup.9 are each independently a
hydrogen atom, optionally substituted lower alkyl, optionally
substituted lower alkenyl, optionally substituted lower alkynyl,
optionally substituted aryl, optionally substituted heteroaryl,
optionally substituted cycloalkyl, optionally substituted aralkyl,
optionally substituted heteroarylalkyl, or optionally substituted
non-aromatic heterocyclic group;
A.sup.1 is a optionally substituted aryl or optionally substituted
heteroaryl; a broken line (---) represents the presence or absence
of a bond, its prodrug, or their pharmaceutically acceptable salt,
or solvate thereof.
[0011] In more detail, the invention relates to the following II)
to XXIX).
II) A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of I), wherein X.sup.1 is optionally substituted
heteroaryl. III) A pharmaceutical composition exhibiting
thrombopoietin receptor agonism of I), wherein X.sup.1 is a group
represented by the formula:
##STR00003##
wherein R.sup.10 and R.sup.11 are each independently a hydrogen
atom, optionally substituted lower alkyl, carboxy, lower
alkyloxycarbonyl, halogen atom, optionally substituted
aminocarbonyl, optionally substituted heteroaryl, or optionally
substituted aryl; R.sup.12 is a hydrogen atom or lower alkyl. IV) A
pharmaceutical composition exhibiting thrombopoietin receptor
agonism which contains a compound of I), wherein X.sup.1 is a group
represented by the formula:
##STR00004##
V) A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of I) to IV), wherein Y.sup.1 is --NHCO--,
--CONH--, --NHCH.sub.2--, --NHCO--CH.dbd.CH--, or --NHSO.sub.2--.
VI) A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of I) to IV), wherein Y.sup.1 is --NHCO--. VII)
A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of I) to VI), wherein Z.sup.1 is 1,4-phenylene
optionally substituted with halogen atom or lower alkyl. VIII) A
pharmaceutical, composition exhibiting thrombopoietin receptor
agonism of any one of I) to VII), wherein R.sup.1 is a hydrogen
atom or lower alkyl. IX) A pharmaceutical composition exhibiting
thrombopoietin receptor agonism of any one of I) to IX), wherein
R.sup.2 is a hydrogen atom, lower alkyl, halogen atom, lower
alkyloxy, lower alkylthio, or optionally substituted amino. X) A
pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of I) to IX), wherein W.sup.1 is a group
represented by the formula:
##STR00005##
wherein R.sup.13 is a hydrogen atom, lower alkyl, lower alkyloxy,
lower alkylthio, or halogen atom; R.sup.14 and R.sup.15 are each
independently a hydrogen atom, or optionally substituted lower
alkyl, optionally substituted lower alkenyl, optionally substituted
lower alkynyl, optionally substituted cycloalkyl, optionally
substituted aryl, optionally substituted heteroaryl, or optionally
substituted heteroarylalkyl, each substituted by one or more
substituent(s) selected from substituent group A; a broken line
(---) is as defined in I); substituent group A consists of a
halogen atom, halo(lower)alkyl, optionally substituted amino,
carboxy, lower alkylthio, lower alkylsilyl, or lower alkyloxy. XI)
A pharmaceutical composition exhibiting thrombopoietin receptor
agonism of any one of I) to IX), wherein W.sup.1 is a group
represented by the formula:
##STR00006##
R.sup.13 is a hydrogen atom, lower alkyl, lower alkyloxy, lower
alkylthio, or halogen a torn; R.sup.26 is a hydrogen atom or lower
alkyl; a broken line (---) is as defined in I);
[0012] XII) A pharmaceutical composition exhibiting thrombopoietin
receptor agonism of any one of I) to XI), which is a platelet
production modifier.
XIII) Use of a compound of any one of I) to XI), for preparation of
a medicine for modifying a platelet production. XIV) A method for
modifying a platelet production of a mammal, including a human,
which comprises administration to said mammal of a compound of any
one of I) to XI) in a pharmaceutically effective amount. XV) A
compound represented by the general formula (II):
X.sup.2--Y.sup.2-Z.sup.2-W.sup.2 (II)
wherein X.sup.2 is optionally substituted 5-member heteroaryl or
optionally substituted pyridyl: Y.sup.2 is
--NR.sup.ACO--(CR.sup.CR.sup.D).sub.0-2--,
--NR.sup.ACO--(CH.sub.2).sub.0-2--V--,
--NR.sup.ACO--CR.sup.C.dbd.CR.sup.D--,
--V--(CH.sub.2).sub.1-5--NR.sup.ACO--(CH.sub.2).sub.0-2,
--V--(CH.sub.2).sub.1-5--CONR.sup.A--(CH.sub.2).sub.0-2--,
--CONR.sup.ACH.sub.2).sub.0-2,
--(CH.sub.2).sub.0-2--NR.sup.ASO.sub.2--(CH.sub.2).sub.0-2--,
--(CH.sub.2).sub.0-2-SO.sub.2--NR.sup.A--(CH.sub.2).sub.0-2--,
--NR.sup.A--(CH.sub.2).sub.0-2--, --NR.sup.A--CO--NR.sup.A--,
--NR.sup.A--CS--NR.sup.A--, --N.dbd.C(--SR.sup.A)--NR.sup.A--,
--NR.sup.ACSNR.sup.A--CO--, --N.dbd.C(--SR.sup.A)--NR.sup.ACO--,
--NR.sup.A--(CH.sub.2).sub.1-2--NR.sup.A--CO--,
--NR.sup.ACONR.sup.ANR.sup.B--CO--, or
--N.dbd.C(--NR.sup.AR.sup.A)--NR.sup.A--CO--, wherein R.sup.A is
each independently a hydrogen atom or lower alkyl; R.sup.B is a
hydrogen atom or phenyl; R.sup.C and R.sup.D are each independently
a hydrogen atom, halogen atom, optionally substituted lower alkyl,
optionally substituted lower alkyloxy, optionally substituted lower
alkylthio, optionally substituted lower alkenyl, optionally
substituted lower alkynyl, optionally substituted aryl, optionally
substituted heteroaryl, optionally substituted cycloalkyl,
optionally substituted aralkyl, optionally substituted
heteroarylalkyl, optionally substituted non-aromatic heterocyclic
group, or optionally substituted amino; V is an oxygen atom or a
sulfur atom; Z.sup.2 is optionally substituted phenylene,
optionally substituted 2,5-pyridino-diyl, optionally substituted
2,5-thiophene-diyl, or optionally substituted 2,5-furan-diyl;
W.sup.2 is a group represented by the formula:
##STR00007##
wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.7, and R.sup.8
are each independently a hydrogen atom, halogen atom, optionally
substituted lower alkyl, optionally substituted lower alkyloxy,
optionally substituted lower alkylthio, optionally substituted
lower alkenyl, optionally substituted lower alkynyl, optionally
substituted aryl, optionally substituted heteroaryl, optionally
substituted cycloalkyl, optionally substituted aralkyl, optionally
substituted heteroarylalkyl, optionally substituted non-aromatic
heterocyclic group, or optionally substituted amino; R.sup.5,
R.sup.6, and R.sup.9 are each independently a hydrogen atom,
optionally substituted lower alkyl, optionally substituted lower
alkenyl, optionally substituted lower alkynyl, optionally
substituted aryl, optionally substituted heteroaryl, optionally
substituted cycloalkyl, optionally substituted aralkyl, optionally
substituted heteroarylalkyl, or optionally substituted non-aromatic
heterocyclic group; A.sup.2 is a optionally substituted aryl or
optionally substituted heteroaryl; a broken line (---) represents
the presence or absence of a bond, its prodrug, or their
pharmaceutically acceptable salt, or solvate thereof. XVI) A
compound described in XV), wherein X.sup.2 is a group represented
by the formula:
##STR00008##
wherein R.sup.10 and R.sup.11 are each independently a hydrogen
atom, optionally substituted lower alkyl, carboxy, lower
alkyloxycarbonyl, halogen atom, optionally substituted
aminocarbonyl, optionally substituted heteroaryl, or optionally
substituted aryl, its prodrug, or their pharmaceutically acceptable
salt, or solvate thereof. XVII) A compound described in XV) or
XVI), wherein X.sup.2 is a group represented by the formula:
##STR00009##
wherein R.sup.16 is a hydrogen atom, optionally substituted lower
alkyl, carboxy, lower alkyloxycarbonyl, halogen atom, or optionally
substituted aminocarbonyl; R.sup.17, R.sup.18, R.sup.19, R.sup.20,
R.sup.21, R.sup.22, and R.sup.23 are each independently a hydrogen
atom, optionally substituted lower alkyl by one or more
substituent(s) selected from substituent group B, cycloalkyl,
optionally substituted alkyoxy by one or more substituent(s)
selected from substituent group B, alkylthio, halogen atom,
optionally substituted phenyl by one or more substituent(s)
selected from substituent group C, optionally substituted
heteroaryl by one or more substituent(s) selected from substituent
group C, or optionally substituted nonaromatic heterocyclic group
by one or more substituent(s) selected from substituent group C;
substituent group B consists of hydroxy, alkyloxy, halogen atom,
carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally
substituted amino, optionally substituted phenyl by one or more
substituent(s) selected from substituent group C, non-aromatic
heterocyclic group, or heteroaryl; substituent group C consists of
hydroxy, alkyl, halogen atom, halo(lower)alkyl, carboxy, lower
alkyloxycarbonyl, alkyloxy, optionally substituted amino,
non-aromatic heterocyclic group, or heteroaryl; R.sup.16 and
R.sup.17 taken together may form --CH.sub.2--,
--CH.sub.2CH.sub.2--, --CH.sub.2CH.sub.2CH.sub.2--, --OCH.sub.2--,
or --SCH.sub.2--; its prodrug, or their pharmaceutically acceptable
salt, or solvate thereof. XVIII) A compound of any one of XV) to
XVII), wherein Y.sup.2 is --NHCO--; its prodrug, or their
pharmaceutically acceptable salt, or solvate thereof. XIX) A
compound of any one of XV) to XVIII), wherein Z.sup.2 is
1,4-phenylene optionally substituted with halogen atom or lower
alkyl; its prodrug, or their pharmaceutically acceptable salt, or
solvate thereof. XX) A compound of any one of XV) to XIX), wherein
R.sup.1 is a hydrogen atom or lower alkyl; its prodrug, or their
pharmaceutically acceptable salt, or solvate thereof. XXI) A
compound of any one of XV) to XX), wherein R.sup.2 is a hydrogen
atom, lower alkyl, halogen atom, lower alkyloxy, lower alkylthio,
or optionally substituted amino; its prodrug, or their
pharmaceutically acceptable salt, or solvate thereof. XXII) A
compound of any one of XV) to XXI), wherein W.sup.2 is a group
represented by the formula:
##STR00010##
wherein, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6,
R.sup.7, R.sup.8 and A.sup.2 are as defined in claim XV); provided
that R.sup.2 is not imidazolyl, triazolyl, or tetrazolyl; its
prodrug, or their pharmaceutically acceptable salt, or solvate
thereof. XXIII) A compound of any one of XV) to XXII), wherein
W.sup.2 is a group represented by the formula:
##STR00011##
wherein R.sup.13 is a hydrogen atom, lower alkyl, lower alkyloxy,
lower alkylthio, or halogen atom; R.sup.14 and R.sup.15 are each
independently a hydrogen atom, or optionally substituted lower
alkyl, optionally substituted lower alkenyl, optionally substituted
lower alkynyl, optionally substituted cycloalkyl, optionally
substituted aryl, optionally substituted heteroaryl, or optionally
substituted heteroarylalkyl, each substituted by one or more
substituent(s) selected from substituent group A; substituent group
A consists of a halogen atom, halo(lower)alkyl, optionally
substituted amino, carboxy, lower alkylthio, lower alkylsilyl, or
lower alkyloxy; its prodrug, or their pharmaceutically acceptable
salt, or solvate thereof. XXIV) A compound of any one of XV) to
XXII), wherein W.sup.2 is a group represented by the formula:
##STR00012##
wherein R.sup.13 is a hydrogen atom, lower alkyl, lower alkyloxy,
lower alkylthio, or halogen atom; R.sup.36 is a hydrogen atom or
lower alkyl; a broken line (---) as defined in XV); its prodrug, or
their pharmaceutically acceptable salt, or solvate thereof. XXV) A
compound represented by the general formula (III):
##STR00013##
wherein R.sup.16 is a hydrogen atom, optionally substituted lower
alkyl, carboxy, lower alkyloxycarbonyl, halogen atom, or optionally
substituted aminocarbonyl; R.sup.17, R.sup.18, R.sup.19, R.sup.20,
and R.sup.21 are each independently a hydrogen atom, optionally
substituted lower alkyl by one or more substituent(s) selected from
substituent group B, cycloalkyl, optionally substituted alkyoxy by
one or more substituent(s) selected from substituent group B,
alkylthio, halogen atom, optionally substituted phenyl by one or
more substituent(s) selected from substituent group C, optionally
substituted heteroaryl by one or more substituent(s) selected from
substituent group C, or optionally substituted nonaromatic
heterocyclic group by one or more substituent(s) selected from
substituent group C; substituent group B consists of hydroxy,
alkyloxy, halogen atom, carboxy, lower alkyloxycarbonyl,
aryloxycarbonyl, optionally substituted amino, optionally
substituted phenyl by one or more substituent(s) selected from
substituent group C, non-aromatic heterocyclic group, or
heteroaryl; substituent group C consists of hydroxy, alkyl, halogen
atom, halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy,
optionally substituted amino, non-aromatic heterocyclic group, or
heteroaryl; R.sup.16 and R.sup.17 taken together may form
--CH.sub.2--, --CH.sub.2CH.sub.2--, --CH.sub.2CH.sub.2CH.sub.2--,
--OCH.sub.2--, or --SCH.sub.2--; R.sup.31 and R.sup.32 are each
independently a hydrogen atom, lower alkyl, halogen atom,
halo(lower)alkyl, lower alkyloxy, halo(lower)alkyloxy, or hydroxy;
W.sup.3 is represented by the formula:
##STR00014##
wherein R.sup.13 is a hydrogen atom, lower alkyl, lower alkyloxy,
lower alkylthio, or halogen atom; R.sup.14 and R.sup.15 are each
independently a hydrogen atom, or optionally substituted lower
alkyl, optionally substituted lower alkenyl, optionally substituted
lower alkynyl, optionally substituted cycloalkyl, optionally
substituted aryl, optionally substituted aralkyl, optionally
substituted heteroaryl, optionally substituted heteroarylalkyl, or
optionally substituted non-aromatic, heterocyclic group, each
substituted by one or more substituent(s) selected from substituent
group A; substituent group A consists of a halogen atom,
halo(lower)alkyl, optionally substituted amino, carboxy, lower
alkylthio, lower alkylsilyl, or lower alkyloxy; R.sup.24 is a
hydrogen atom or lower alkyl; R.sup.25 is lower alkyl, optionally
substituted aryl, or optionally substituted non-aromatic
heterocyclic group; A.sup.3 is heteroaryl; its prodrug, or their
pharmaceutically acceptable salt, or solvate thereof. XXVI) A
compound represented by the general formula (IV-A):
##STR00015##
wherein R.sup.27 is a hydrogen atom, C1-C3 alkyl, trifluoromethyl,
or halogen atom; R.sup.28, R.sup.29, and R.sup.30 are independently
a hydrogen atom, optionally substituted lower alkyl by one or more
substituent(s) selected from substituent group B, cycloalkyl,
optionally substituted alkyoxy by one or more substituent(s)
selected from substituent group B, alkylthio, halogen atom,
optionally substituted phenyl by one or more substituent(s)
selected from substituent group C, optionally substituted
heteroaryl by one or more substituent(s) selected from substituent
group C, or optionally substituted nonaromatic heterocyclic group
by one or more substituent(s) selected from substituent group C;
substituent group B consists of hydroxy, alkyloxy, halogen atom,
carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally
substituted amino, optionally substituted phenyl by one or more
substituent(s) selected from substituent group C, non-aromatic
heterocyclic group, or heteroaryl; substituent group C consists of
hydroxy, alkyl, halogen atom, halo(lower)alkyl, carboxy, lower
alkyloxycarbonyl, alkyloxy, optionally substituted amino,
non-aromatic heterocyclic group, or heteroaryl; R.sup.31 and
R.sup.32 are each independently a hydrogen atom, lower alkyl,
halogen atom, haro(lower)alkyl, lower alkyloxy,
halo(lower)alkyloxy, or hydroxy; W.sup.4 is a group represented by
the formula:
##STR00016##
wherein R.sup.13 is a hydrogen atom, lower alkyl, lower alkyloxy,
lower alkylthio, or halogen atom; R.sup.14 and R.sup.15 are each
independently a hydrogen atom, optionally substituted lower alkyl,
optionally substituted lower alkenyl, optionally substituted lower
alkynyl, optionally substituted cycloalkyl, optionally substituted
aryl, optionally substituted aralkyl, optionally substituted
heteroaryl, optionally substituted heteroarylalkyl, or optionally
substituted non-aromatic heterocyclic group, each substituted by
one or more substituent(s) selected from substituent group A;
substituent group A consists of a halogen atom, halo(lower)alkyl,
optionally substituted amino, carboxy, lower alkylthio, lower
alkylsilyl, or lower alkyloxy; R.sup.24 is a hydrogen atom or lower
alkyl; its prodrug, or their pharmaceutically acceptable salt, or
solvate thereof. XXVII) A compound represented by the general
formula (IV-B):
##STR00017##
wherein R.sup.28, R.sup.29, and R.sup.30 are each independently a
hydrogen atom, optionally substituted lower alkyl by one or more
substituent(s) selected from substituent group B, cycloalkyl,
optionally substituted alkyoxy by one or more substituent(s)
selected from substituent group B, alkylthio, halogen atom,
optionally substituted phenyl by one or more substituent(s)
selected from substituent group C, optionally substituted
heteroaryl by one or more substituent(s) selected from substituent
group C, or optionally substituted nonaromatic heterocyclic group
by one or more substituent(s) selected from substituent group C;
substituent group B consists of hydroxy, alkyloxy, halogen atom,
carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally
substituted amino, optionally substituted phenyl by one or more
substituent(s) selected from substituent group C, non-aromatic
heterocyclic group, or heteroaryl; substituent group C consists of
hydroxy, alkyl, halogen atom, halo(lower)alkyl, carboxy, lower
alkyloxycarbonyl, alkyloxy, optionally substituted amino,
non-aromatic heterocyclic group, or heteroaryl; R.sup.31 and
R.sup.32 are each independently a hydrogen atom, lower alkyl,
halogen atom, haro(lower)alkyl, lower alkyloxy,
halo(lower)alkyloxy, or hydroxy; W.sup.4 is a group represented by
the formula:
##STR00018##
wherein R.sup.13 is a hydrogen atom, lower alkyl, lower alkyloxy,
lower alkylthio, or halogen atom; R.sup.14 and R.sup.15 are each
independently a hydrogen atom, optionally substituted lower alkyl,
optionally substituted lower alkenyl, optionally substituted lower
alkynyl, optionally substituted cycloalkyl, optionally substituted
aryl, optionally substituted aralkyl, optionally substituted
heteroaryl, optionally substituted heteroarylalkyl, or optionally
substituted non-aromatic heterocyclic group, each substituted by
one or more substituent(s) selected from substituent group A;
substituent group A consists of a halogen atom, halo(lower)alkyl,
optionally substituted amino, carboxy, lower alkylthio, lower
alkylsilyl, or lower alkyloxy; R.sup.24 is a hydrogen atom or lower
alkyl;
T is --CH.sub.2--, --CH.sub.2CH.sub.2--,
--CH.sub.2CH.sub.2CH.sub.2--, --OCH.sub.2--, or --SCH.sub.2--;
[0013] its prodrug, or their pharmaceutically acceptable salt, or
solvate thereof. XXVIII) A pharmaceutical composition containing as
the active ingredient a compound of any one of XV) to XXVII). XXIX)
A pharmaceutical composition containing as the active ingredient a
compound of any one of XV) to XXVII), which is exhibiting
thrombopoietin receptor agonism. XXX) A platelet production
modifier which contains as the active ingredient a compound of any
one of XV) to XXVII). XXXI) Use of a compound of any one of XV) to
XXVII) for preparation of a pharmaceutical composition for
modifying a platelet production. XXXII) A method for modifying a
platelet production of a mammal, including a human, which comprises
administration to said mammal of a compound of any one of XV) to
XXVII) in a pharmaceutically effective amount.
[0014] In the present specification, the term "halogen" means
fluoro, chloro, bromo, and iodo.
[0015] In the present specification, the term "alkyl" employed
alone or in combination with other terms means a straight- or
branched chain monovalent hydrocarbon group having 1 to 15 carbon
atom(s). Examples of alkyl include methyl, ethyl, n-propyl,
isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl,
isopentyl, neo-pentyl, n-hexyl, isohexyl, n-heptyl, n-octyl,
n-nonanyl, n-decanyl, n-undecanyl, n-dodecanyl, n-tridecanyl,
n-tetradecanyl, n-pentadecanyl, and the like. C1 to C10 alkyl is
preferred. C1 to C6 alkyl is more preferred.
[0016] In the present specification, the term "lower alkyl"
employed alone or in combination with other terms means a straight-
or branched chain monovalent hydrocarbon group having 1 to 8 carbon
atom(s). Examples of alkyl include methyl, ethyl, n-propyl,
isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl,
isopentyl, neo-pentyl, n-hexyl, isohexyl, n-heptyl, n-octyl, and
the like. C1 to C6 alkyl is preferred. C1 to C3 alkyl is more
preferred.
[0017] In the present specification, the term "C1 to C3 alkylene"
include methylene, ethylene, propylene, and the like.
[0018] In the present specification, the term "cycloalkane"
employed alone or in combination with other terms means a mono
cycloalkane having 3 to 8 carbon atom. Examples of cycloalkane
include cyclopropane, cyclobutane, cyclopentane, cyclohexane,
cycloheptane, cyclooctane, and the like. C3 to C6 cycloalkane is
preferred.
[0019] In the present specification, the term "cycloalkyl" employed
alone or in combination with other terms means a mono cycloalkane
having 3 to 8 carbon atom. Examples of cycloalkyl include
cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl,
cyclooctyl, and the like. C3 to C6 cycloalkyl is preferred.
[0020] The term "lower alkenyl" in the present specification means
a straight- or branched chain monovalent hydrocarbon group having 2
to 8 carbon atoms and one or more double bond. Examples of the
alkenyl include vinyl, allyl, 1-propenyl, 2-propenyl, a variety of
butenyl isomers and the like. C2 to C6 alkenyl is preferred. C2 to
C4 alkenyl is more preferred.
[0021] The term "lower alkynyl" used in the present specification
means a straight or branched chain monovalent hydrocarbon group
having 2 to 8 carbon atoms and one or more than two triple bond.
Examples of the alkynyl include ethynyl, 1-propynyl, 2-propynyl,
1-propenyl, 2-propenyl, crotonyl, isopentenyl, a variety of butenyl
isomers and the like. C2 to C6 alkynyl is preferred. C2 to C4
alkynyl is more preferred.
[0022] In the present specification, the term "aryl" employed alone
or in combination with other terms means monocyclic or condensed
ring aromatic hydrocarbons. Examples of aryl include phenyl,
1-naphtyl, 2-naphtyl, anthryl, and the like.
[0023] The term "aralkyl" herein used means the above mentioned
"lower alkyl" substituted with the above mentioned "aryl" at any
possible position. Examples of the aralkyl are benzyl, phenethyl
(e.g., 2-phenethyl), phenylpropyl (e.g., 3-phenylpropyl),
naphthylmethyl (e.g., 1-naphthylmethyl and 2-naphthylmethyl),
anthrylmethyl (e.g., 9-anthrylmethyl), and the like. Benzyl and
phenylethy are preferred.
[0024] In the present specification, the term "non-aromatic
heterocyclic group" employed alone or in combination with other
terms means a 5 to 7 membered non-aromatic ring which contains one
or more hetero atoms selected from the group consisting of oxygen,
sulfur, and nitrogen atoms in the ring and the 5 to 7 membered
non-aromatic ring may be condensed with two or more rings. Examples
of the non-aromatic heterocyclic group are pyrrolidinyl (e.g.,
1-pyrrolidinyl, 2-pyrrolidinyl), pyrrolinyl (e.g., 3-pyrrolinyl),
imidazolidinyl (e.g., 2-imidazolidinyl), imidazolinyl (e.g.,
imidazolinyl), pyrazolidinyl (e.g., 1-pyrazolidinyl,
2-pyrazolidinyl), pyrazolinyl (e.g., pyrazolinyl), piperidinyl
(e.g., piperidino, 2-piperidinyl), piperazinyl (e.g.,
1-piperazinyl), indolynyl (e.g., 1-indolynyl), isoindoinyl (e.g.,
isoindolinyl), morpholinyl (e.g., morpholino, 3-morpholinyl),
tetrahydrofuranyl, tetrahydropyranyl, and the like.
[0025] Preferable are morpholino, piperazino, pyrrolidino,
teterahydrofuranyl, tetrahydropyranyl, and the like as
"non-aromatic heterocyclic group" of R.sup.17, R.sup.18, R.sup.19,
R.sup.20, R.sup.21, R.sup.22, R.sup.23, R.sup.28, R.sup.29, and
R.sup.30.
[0026] Preferable are morpholino, piperazino, piperidino,
tetrahydrofuranyl, tetrahydropyranyl, and the like as "non-aromatic
heterocyclic group" of substituent group B.
[0027] Preferable are morpholino, piperazino, piperidino,
pyrrolidino, teterahydrofuranyl, tetrahydropyranyl, and the like as
"non-aromatic heterocyclic group" of substituent group C.
[0028] In the present specification, the term "heteroaryl" employed
alone or in combination with other terms means a 5 to 6 membered
aromatic heterocyclic group which contains one or more hetero atoms
selected from the group consisting of oxygen, sulfur, and nitrogen
atoms in the ring and may be fused with above mentioned cycloalkyl,
above mentioned aryl, above mentioned non-aromatic heterocyclic
group, and other heteroaryl at any possible position. Examples of
the heteroaryl are pyrrolyl (e.g., 1-pyrrolyl, 2-pyrrolyl,
3-pyrrolyl), furyl (e.g., 2-furyl, 3-furyl), thienyl (e.g.,
2-thienyl 3-thienyl), imidazolyl (e.g., 2-imidazolyl,
4-imidazolyl), pyrazolyl (e.g., 1-pyrazolyl, 3-pyrazolyl),
isothiazolyl (e.g., 3-isothiazolyl), isoxazolyl (e.g.,
3-isoxazolyl), oxazolyl (e.g., 2-oxazolyl), thiazolyl (e.g.,
2-thiazolyl), pyridyl (e.g., 2-pyridyl, 3-pyridyl, 4-pyridyl),
pyrazinyl (e.g., 2-pyrazinyl), pyrimidinyl (e.g., 2-pyrimidinyl,
4-pyrimidinyl), pyridazinyl (e.g., 3-pyridazinyl), tetrazolyl(e.g.,
1H-tetrazolyl), oxadiazolyl (e.g., 1,3,4-oxadiazolyl); thiadiazolyl
(e.g., 1,3,4-thiadiazolyl), indolizinyl (e.g., 2-indolizinyl,
6-indolizinyl), isoindolyl (2-isoindolyl), indolyl (e.g.,
1-indolyl, 2-indolyl, 3-indolyl), indazolyl (e.g., 3-indazolyl),
puriyl (e.g., 8-puriyl), quinolizinyl (e.g., 2-quinolizinyl),
isoquinolyl (e.g., 3-isoquinolyl), quinolyl (e.g., 3-quinolyl,
5-quinolyl), phthalazinyl (e.g., 1-phthalazinyl), naphthyridinyl
(e.g., 2-naphthyridinyl), quinolanyl (2-quinolanyl), quinazolinyl
(e.g., 2-quinazolinyl), cinnolinyl (e.g., 3-cinnolinyl), pteridinyl
(e.g., 2-pteridinyl), carbazolyl (e.g., 2-carbazolyl,
4-carbazolyl), phenanthridinyl (e.g., 2-phenanthridinyl,
3-phenanthridinyl), acridinyl (e.g., 1-acridinyl, 2-acridinyl),
dibenzofuranyl (e.g., 1-dibenzofuranyl, 2-dibenzofuranyl),
benzimidazolyl (e.g., 2-benzimidazolyl), benzisoxazolyl (e.g.,
3-benzisoxazolyl), benzoxazolyl (e.g., 2-benzoxazolyl),
benzoxadiazolyl (e.g., 4-benzoxadiazolyl), benzisothiazolyl (e.g.,
3-benzisothiazolyl), benzothiazolyl (e.g., 2-benzothiazolyl),
benzofuryl (e.g., 3-benzofuryl), benzothienyl (e.g.,
2-benzothienyl), 4,5-dihydronaphtho[1,2-d]thiazolyl,
4H-chromeno[4,3-d]thiazolyl, 4H-thiochromeno[4,3-d]thiazolyl,
4,5-dihydrothiazo[5,4-c]quinolyl, 8H-indeno[1,2-d]thiazolyl,
5,6-dihydro-4H-3-thia-1-aza-benzo[e]azurenyl and the like.
[0029] Preferable are thiazolyl, isoxazolyl, thienyl, carbazolyl,
benzothiazolyl, pyridyl, pyrazolyl, and the like as "heteroaryl"
for X.sup.1. More preferable are thiazolyl, pyridyl, and the
like.
[0030] Preferable are pyridyl, thiazolyl, benzothiazolyl, and the
like as "heteroaryl" for R.sup.1, R.sup.2, R.sup.3, R.sup.4,
R.sup.7, and R.sup.8.
[0031] Preferable are pyridyl, thienyl, furyl, pyrimidinyl,
imidazolyl, thiazolyl, oxazolyl, triazolyl, and the like as
"heteroaryl" for R.sup.10 and R.sup.11.
[0032] Preferable are imidazolyl, triazolyl, tetrazolyl, pyridyl,
pyrimidinyl, and the like as "heteroaryl" for A.sup.1, A.sup.2, and
A.sup.3.
[0033] Preferable are pyridyl, thienyl, furyl, pyrimidinyl,
imidazolyl, thiazolyl, oxazolyl, triazolyl, and the like as
"heteroaryl" for R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21,
R.sup.22, R.sup.23, R.sup.28, R.sup.19, and R.sup.30.
[0034] Preferable are pyridyl, pyrazolyl, pyrimidinyl, imidazolyl,
oxazolyl, triazolyl, furyl, thienyl and the like as "heteroaryl"
for substituent group B.
[0035] Preferable are pyridyl, pyrazolyl, imidazolyl, and the like
as "heteroaryl" for substituent group C.
[0036] In the present specification, the term "5-membered
heteroaryl" means a 5 membered aromatic heterocyclic group which
contains one or more hetero atoms selected from the group
consisting of oxygen, sulfur, and nitrogen atoms. Examples of the
5-membered heteroaryl are thienyl, furyl, pyrrolyl, imidazolyl,
pyrazolyl, isothiazolyl, isoxazolyl, thiazolyl, oxazolyl,
1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,4-thiadiazolyl,
1,3,4-thiadiazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, and the
like. Preferable is thiazolyl.
[0037] The term "heteroarylalkyl" herein used means the
above-mentioned "lower alkyl" substituted with the above-mentioned
"heteroaryl" at any possible position. Examples of the
heteroarylalkyl are thienylmethyl (e.g., 2-thienylmethyl),
thienylethyl (e.g., 2-(thiophen-2-yl)ethyl), furylmethyl (e.g.,
2-furylmethyl), furylethyl (e.g., 2-(furan-2-yl)ethyl),
pyrrolylmethyl (e.g., 2-pyrrolylmethyl), pyrrolylethyl (e.g.,
2-(pyrrol-2-yl)ethyl), imidazolylmethyl (e.g., 2-imidazolylmethyl,
4-imidazolylmethyl), imidazolylethyl (e.g.,
2-(imidazol-2-yl)ethyl), pyrazolylmethyl (e.g., 3-pyrazolylmethyl),
pyrazolylmethyl (e.g., 2-(pyrazol-3-yl)ethyl), thiazolylmethyl
(e.g., 2-thiazolylmethyl), thiazolylethyl (e.g.,
2-(thiazol-2-yl)ethyl), isothiazolylmethyl (e.g.,
3-thiazolylmethyl), isoxazolylmethyl (e.g., 3-isoxazolylmethyl),
oxazolylmethyl (e.g., 2-oxazolylmethyl), oxazolylethyl (e.g.,
2-(oxazol-2-yl)ethyl), pyridylmethyl (e.g., 2-pyridylmethyl,
3-pyridylmethyl, 4-pyridylmethyl), pyridylethyl (e.g.,
2-pyridylethyl) and the like.
[0038] Preferable are 2-thienylmethyl, 2-furylmethyl, and the like
as "heteroarylalkyl" for R.sup.1, R.sup.2, R.sup.3, R.sup.4,
R.sup.7, and R.sup.8.
[0039] The term "phenylene" herein used means a divalent group of
the above-mentioned "phenyl". Examples of the phenylene are
1,2-phenylene, 1,3-phenylene, 1,4-phenylene, and the like.
Preferable is 1,4-phenylene.
[0040] The term "monocyclic heteroarylene" herein used means a
monocyclic heteroaryl divalent group of the above-mentioned
"heteroaryl". Examples of the heteroarylene are thiophene-diyl,
furan-diyl, pyridine-diyl, and the like. Mentioned in more detail,
it is exemplified by 2,5-thiophene-diyl, 2,5-furan-diyl,
2,5-pyridine-diyl, 2,5-thiazole-diyl, 2,5-(1,3,4-thiadiazole)-diyl,
2,5-pyridine-diyl, 2,5-parazine-diyl, 3,6-pyridazine-diyl,
2,5-(4H-pyrane)-diyl, and the like. Preferable are
2,5-thiophene-diyl, 2,5-furan-diyl, 2,5-pyridine-diyl.
[0041] The term "monocyclic non-aromatic heterocycle-diyl" herein
used means a divalent group of an above-mentioned "monocyclic
non-aromatic heterocyclic group". Examples of the non-aromatic
heterocycle-diyl are pyrrolidine-diyl, piperidine-diyl,
pyrazine-diyl and the like.
[0042] The term "monocyclic cycloalkane-diyl" herein used means a
divalent group of the above-mentioned "monocyclic cycloalkyl".
Examples of the cycloalkyl-diyl are 1,4-cyclopentane-diyl,
1,4-cyclohexane-diyl and the like.
[0043] The term "alkyloxy" herein used are methyloxy, ethyloxy,
n-propyloxy, 1-propyloxy, n-butyloxy, i-butyloxy, sec-butyloxy,
tert-butyloxy, n-pentyloxy, n-hexyloxy, n-heptyloxy, n-octyloxy,
n-nonanyloxy, n-decanyloxy, and the like. Methyloxy, ethyloxy,
n-propyloxy, i-propyloxy and n-butyloxy are preferred.
[0044] The term "lower alkyloxy" herein used are methyloxy,
ethyloxy, n-propyloxy, i-propyloxy, n-butyloxy, i-butyloxy,
sec-butyloxy, tert-butyloxy, and the like. Methyloxy, ethyloxy,
n-propyloxy, i-propyloxy and n-butyloxy are preferred.
[0045] The term "lower alkylthio" herein used are methylthio,
ethylthio, and 1 the like.
[0046] The term "lower alkyloxycarbonyl" herein used are
methyloxycarbonyl, ethyloxycarbonyl, n-propyloxycarbonyl,
isopropyloxycarbonyl, n-butyloxycarbonyl, t-butyloxycarbonyl,
n-pentyloxycarbonyl and the like.
[0047] The term "aryloxycarbonyl" herein used are
phenyloxycarbonyl, 1-naphthyloxycarbonyl, 2-naphthyloxycarbonyl,
and the like.
[0048] In the present specification, the term "acyl" employed alone
or in combination with other terms means alkylcarbonyl in which
alkyl group is the above-mentioned "lower alkyl" and arylcarbonyl
in which aryl group is the above-mentioned "aryl". Examples of the
acyl are acetyl, propyonyl, benzoyl, and the like. "Lower alkyl"
and "aryl" may be substituted respectively with substituents
mentioned below.
[0049] In the present specification, the term "halo(lower)alkyl"
employed alone or in combination with other terms means the
above-mentioned "lower alkyl" which is substituted with the above
mentioned "halogen" at 1 to 8 positions, preferably, at 1 to 5.
Examples of the halo(lower)alkyl are trifluoromethyl,
trichloromethyl, difluoroethyl, trifluoroethyl, dichloroethyl,
trichloroethyl, and the like. Preferable is trifluoromethyl.
[0050] The term "halo(lower)alkyl" herein used are trifluoromethyl,
trichloromethyl, difluoroethyl, trifluoroethyl, dichloroethyl,
trichloroethyl, and the like. Preferable is trifluoromethyl.
[0051] Examples of the term "acyloxy" herein used are acetyloxy,
propionyloxy, benzoyloxy and the like.
[0052] Examples of the term "lower alkylsilyl" herein used are
triethylsilyl, t-butyldimethylsilyl, and the like.
[0053] In the present specification, the term "optionally
substituted amino" employed alone or in combination with other
terms includes amino substituted with one or two of the above
mentioned "lower alkyl", "aralkyl", "heteroarylalkyl" or "acyl".
Examples of the optionally substituted amino are amino,
methylamino, dimethylamino, ethylmethylamino, diethylamino,
benzylamino, acetylamino, benzoylamino and the like. Preferable are
amino, methylamino, dimethylamino, ethylmethylamino, diethylamino
and acetylamino.
[0054] Examples of the term "optionally substituted aminocarbonyl"
herein used are aminocarbonyl, methylaminocarbonyl,
dimethylaminocarbonyl, ethylmethylaminocarbonyl,
diethylaminocarbonyl and the like. Preferable are aminocarbonyl,
methylaminocarbonyl, and dimethylaminocarbonyl.
[0055] In the present specification, the term "optionally
substituted ureide" includes ureide substituted with one or more
than two of the above mentioned "lower alkyl", "aryl", "aralkyl",
"heteroaryl", "heteroarylalkyl" or "acyl".
[0056] The substituents of "optionally substituted lower alkyl" are
cycloalkyl, lower alkenyl, lower alkyliden, hydroxy, lower
alkyloxy, mercapto, lower alkylthio, halogen, nitro, cyano,
carboxy, lower alkyloxycarbonyl, halo(lower)alkyl,
halo(lower)alkyloxy, optionally substituted amino, optionally
substituted aminocarbonyl, acyl, acyloxy, optionally substituted
non-aromatic heterocyclic group, aryloxy (e.g., phenyloxy),
aralkyloxy (e.g., benzyloxy), lower alkylsulfonyl, guanidino, azo
group, optionally substituted ureide, .dbd.N--O-- (acyl) and the
like. These substituents are able to locate at one or more of any
possible positions.
[0057] Preferable are halogen atom, or halo(lower)alkyl, as
substituents of "optionally substituted lower alkyl" for R.sup.C
and R.sup.D.
[0058] Preferable are hydroxy, carboxy, halogen atom, alkyloxy,
alkylthio, alkylsilyl, optionally substituted amino, cyano, acyl,
and the like as substituents of "optionally substituted lower
alkyl" for R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6,
R.sup.7, R.sup.8, and R.sup.9.
[0059] Preferable are lower alkyloxycarbonyl and halogen atom as
substituents of "optionally substituted lower alkyl" for R.sup.10,
R.sup.11, and R.sup.16.
[0060] Preferable are cycloalkyl, lower alkenyl, lower alkylidene
as substituents of "optionally substituted lower alkyl" for
R.sup.12.
[0061] The substituents of "optionally substituted lower alkyloxy"
and "optionally substituted lower alkylthio" are cycloalkyl, lower
alkenyl, lower alkyliden, hydroxy, lower alkyloxy, mercapto, lower
alkylthio, halogen, nitro, cyano, carboxy, lower alkyloxycarbonyl,
halo(lower)alkyl, halo(lower)alkyloxy, optionally substituted
amino, optionally substituted aminocarbonyl, acyl, acyloxy,
optionally substituted non-aromatic heterocyclic group, aryloxy
(e.g. phenyloxy), aralkyloxy (e.g., benzyloxy), lower
alkylsulfonyl, guanidino, azo group, optionally substituted ureide,
.dbd.N--O-- (acyl) and the like. These substituents are able to
locate at one or more of any possible positions.
[0062] The substituents of "optionally substituted lower alkenyl"
and "optionally substituted lower alknyl" are cycloalkyl, lower
alkenyl, lower alkyliden, hydroxy, lower alkyloxy, mercapto, lower
alkylthio, halogen, nitro, cyano, carboxy, lower alkyloxycarbonyl,
halo(lower)alkyl, halo(lower)alkyloxy, optionally substituted
amino, optionally substituted aminocarbonyl, acyl, acyloxy,
optionally substituted non-aromatic heterocyclic group, aryloxy
(e.g., phenyloxy), aralkyloxy (e.g., benzyloxy), lower
alkylsulfonyl, guanidino, azo group, optionally substituted ureide,
and the like. These substituents are able to locate at one or more
of any possible positions.
[0063] The substituents of "optionally substituted phenylene",
"optionally substituted heteroarylene", "optionally substituted
2,5-pyridine-diyl", "optionally substituted 2,5-thiophene-diyl",
"optionally substituted 2,5-furan-diyl", "optionally substituted
monocyclic non-aromatic heterocycle-diyl", "optionally substituted
monocyclic cycloalkane-diyl", "optionally substituted aryl",
"optionally substituted phenyl", "optionally substituted
heteroaryl", "optionally substituted 5-membered heteroaryl",
"optionally substituted pyridyl", "optionally substituted
non-aromatic heterocyclic group", "optionally substituted
cycloalkyl", "optionally substituted aralkyl", and "optionally
substituted heteroarylalkyl" herein used are optionally substituted
alkyl, cycloalkyl, lower alkenyl, lower alkynyl, hydroxy, alkyloxy,
aralkyloxy, mercapto, lower alkylthio, halogen, nitro, cyano,
carboxy, lower alkyloxycarbonyl, halo(lower)alkyl,
halo(lower)alkyloxy, optionally substituted amino, optionally
substituted aminocarbonyl, acyl, acyloxy, optionally substituted
aryl (which is substituted by halogen atom, carboxy, alkyl, or
alkyloxy, and the like), optionally substituted heteroaryl (which
is substituted by halogen atom, carboxy, alkyl, or alkyloxy, and
the like), optionally substituted non-aromatic heterocyclic group,
optionally substituted aralkyl, lower alkylsulfonyl, guanidino, azo
group, --N.dbd.N-(optionally substituted phenyl) or optionally
substituted ureide and the like. These substituents are able to
locate at one or more of any possible positions.
[0064] Preferable are halogen, nitro, cyano, lower alkyl, lower
alkyloxy, and the like as substituents of "optionally substituted
phenylene", "optionally substituted heteroarylene", "optionally
substituted 2,5-pyridine-diyl", "optionally substituted
2,5-thiophehe-diyl", "optionally substituted 2,5-furan-diyl",
"optionally substituted monocyclic non-aromatic heterocycle-diyl",
"optionally substituted monocyclic cycloalkyl-diyl". Their
unsubstituted one is preferred.
[0065] The examples of substituents of "optionally substituted
aryl" and "optionally substituted aralkyl" for X.sup.1 are lower
alkyl, hydroxy lower alkyl, hydroxy, lower alkyloxy, lower
alkylthio, halogen, nitro, cyano, carboxy, lower halo(lower)alkyl,
halo(lower)alkyloxy, aralkyloxy, unsubstituted or substituted
amino, unsubstituted or substituted aminocarbonyl, aryl,
heteroaryl, non-aromatic heterocyclic group, arylazo (e.g.,
phenylazo), and the like. Preferable substituents are lower alkyl,
hydroxy, lower alkyloxy, lower alkylthio, halogen,
halo(lower)alkyl, halo(lower)alkyloxy, aralkyloxy,
--N.dbd.N-(phenyl), alkylenedioxy, and the like.
[0066] The examples of "optionally substituted aryl" for X.sup.1
are phenyl, 3-methylphenyl, 4-methylphenyl, 3,4-dimethylphenyl,
4-ethylphenyl, 4-t-buylphenyl, 4-n-buylphenyl, 4-n-hexylphenyl,
4-n-octylphenyl, 3,5-di-t-butyl-4-hydroxyphenyl, 4-ethyloxyphenol,
4-fluorophenyl, 3,4-dichlorophenyl, 3,5-dichlorophenyl,
4-iodophenyl, 4-trifluoromethylphenyl, 4-methylthiophenyl,
4-phenylmethyloxyphenyl, 4-phenylazophenyl, 4-phenylphenyl,
2-naphtyl, benzodioxoyl (e.g., 1'-benzodioxolyl), and the like.
[0067] The substituents of "optionally substituted aryl" for
R.sup.10 and R.sup.11 are halogen atom, optionally substituted
alkyl, cycloalkyl, lower alkenyl, lower alkynyl, hydroxy, lower
alkyloxy, mercapto, lower alkylthio, nitro, cyano, carboxy, lower
alkyloxycarbonyl, halo(lower)alkyl, halo(lower)alkyloxy, optionally
substituted aminos optionally substituted aminocarbonyl, acyl,
formyl, acyloxy, optionally substituted aryl, optionally
substituted heteroaryl (e.g., pyridyl, imidazolyl), non-aromatic
heterocyclic group (e.g., morpholino, piperazinyl), aralkyl, and
the like. Preferable are optionally substituted alkyl by one or
more substituent(s) selected from substituent group B, cycloalkyl,
optionally substituted alkyloxy by one or more substituent(s)
selected from substituent group B, alkylthio, halogen atom,
optionally substituted phenyl by one or more substituent(s)
selected from substituent group C, optionally substituted
heteroaryl by one or more substituent(s) selected from substituent
group C, optionally substituted non-aromatic heterocyclic group by
one or more substituent(s) selected from substituent group C, and
the like.
[0068] Substituent group B consists of hydroxy, alkyloxy, halogen
atom, carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally
substituted amino, optionally substituted phenyl by one or more
substituent(s) selected from substituent group C, non-aromatic
heterocyclic group, and heteroaryl.
[0069] Substituent group C consists of hydroxy, alkyl, halogen
atom, halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy,
optionally substituted amino, non-aromatic heterocyclic group, and
heteroaryl.
[0070] The aryl may be fused with C5-C7 cycloalkane (e.g.,
cyclopentane, cyclohexane) and non-aromatic heterocyclic group
(e.g., tetrahydrofuranyl, 1,3-dioxolyl, 1,4-dioxynyl, pyrrolidinyl)
to form indane, 1,2,3,4-tetrahydronaphthalene,
1,2,3,4-tetrahydroquinoline, 2,3-dihydrobenzo[1,4]dioxyline,
benzo[1,3]dioxole, 2,3-dihydrobenzofuran,
2,3-dihydro-1H-indole.
[0071] The substituents of "optionally substituted heteroaryl" and
"optionally substituted heteroarylalkyl" for X.sup.1 are optionally
substituted alkyl, lower alkenyl (e.g., .dbd.CH--CH.sub.3, lower
alknyl, hydroxy, lower alkyloxy, mercapto, lower alkylthio,
halogen, nitro, cyano, carboxy, lower alkyloxycarbonyl,
halo(lower)alkyl, halo(lower)alkyloxy, optionally substituted
amino, optionally substituted aminocarbonyl, acyl (e.g., optionally
substituted aryloxycarbonyl by halogen atom nitro, cyano, and the
like) acyloxy, optionally substituted aryl, optionally substituted
heteroaryl (e.g., 2-pyridyl, 3-pyridyl, 4-pyridyl, 3-thienyl,
5-methylpyridin-2-yl, 3-quinolyl, 5-chlorothiophen-2-yl,
5-bromothiophen-2-yl), non-aromatic heterocyclic group, aralkyl,
.dbd.N--O-- (acyl) and the like. Preferable are optionally
substituted lower alkyl, lower alkenyl, lower alkyloxycarbonyl,
optionally substituted phenyl, heteroaryl, .dbd.N--O-- (acyl) and
the like.
[0072] In the case of heteroatom is nitrogen atom, the nitrogen
atom may be substituted by alkyl, oxo, and the like.
[0073] The substituents of "optionally substituted 5-membered
heteroaryl" for X.sup.3 are optionally substituted lower alkyl,
lower alkenyl (e.g., .dbd.CH--CH.sub.3), lower alkynyl, hydroxy,
lower alkyloxy, mercapto, lower alkylthio, halogen, nitro, cyano,
carboxy, lower alkyloxycarbonyl, halo(lower)alkyl,
halo(lower)alkyloxy, optionally substituted amino, optionally
substituted aminocarbonyl, acyl (e.g., aryloxycarbonyl optionally
substituted with halogen, nitro, cyano and the like), acyloxy,
optionally substituted phenyl, aryl, optionally substituted
heteroaryl (e.g., 2-pyridyl, 3-pyridyl, 4-pyridyl, 3-thienyl,
5-methylpyridine-2-yl, 3-quinolyl, 5-chlorothiophene-2-yl,
5-bromothiophene-2-yl), non-aromatic heterocyclic group, aralkyl,
.dbd.N--O-(acyl), and the like. Preferable are optionally
substituted alkyl by one or more substituent(s) selected from
substituent group B, cycloalkyl, optionally substituted alkyloxy by
one or more substituent(s) selected from substituent group B,
alkylthio, halogen atom, optionally substituted phenyl by one or
more substituent(s) selected from substituent group C, optionally
substituted heteroaryl by one or more substituent(s) selected from
substituent group C, or optionally substituted non-aromatic
heterocyclic group by one or more substituent(s) selected from
substituent group C, and the like.
[0074] Substituent group B consists of hydroxy, alkyloxy, halogen
atom, carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally
substituted amino, optionally substituted phenyl by one or more
substituent(s) selected from substituent group C, non-aromatic
heterocyclic group, and heteroaryl,
[0075] Substituent group C consists of hydroxy, alkyl, halogen
atom, halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy,
optionally substituted amino non-aromatic heterocyclic group, and
heteroaryl,
[0076] The substituents of "optionally substituted aryl" for
R.sup.10 and R.sup.11 are halogen atom, optionally substituted
alkyl, cycloalkyl, lower alkenyl, lower alkynyl, hydroxy, lower
alkyloxy, mercapto, lower alkylthio, nitro, cyano, carboxy, lower
alkyloxycarbonyl, halo(lower)alkyl, halo(lower)alkyloxy, optionally
substituted amino, optionally substituted aminocarbonyl, acyl,
formyl, acyloxy, optionally substituted aryl, optionally
substituted heteroaryl (e.g., pyridyl, imidazolyl), non-aromatic
heterocyclic group (e.g., morpholino, piperazinyl), aralkyl, and
the like. Preferable are optionally substituted alkyl by one or
more substituent(s) selected from substituent group B, cycloalkyl,
optionally substituted alkyloxy by one or more substituent(s)
selected from substituent group B, alkylthio, halogen atom,
optionally substituted phenyl by one or more substituent(s)
selected from substituent group C, optionally substituted
heteroaryl by one or more substituent(s) selected from substituent
group C, optionally substituted non-aromatic heterocyclic group by
one or more substituent(s) selected from substituent group C, and
the like,
[0077] Substituent group B consists of hydroxy, alkyloxy, halogen
atom, carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally
substituted amino, optionally substituted phenyl by one or more
substituent(s) selected from substituent group C, non-aromatic
heterocyclic group, and heteroaryl.
[0078] Substituent group C consists of hydroxy, alkyl, halogen
atom, halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy,
optionally substituted amino, non-aromatic heterocyclic group, and
heteroaryl.
[0079] In the present specification, the term
"(.alpha.).sub..beta.-.gamma." means that .alpha. is present of
number of .beta. to .gamma.. Examples of
"(.alpha.).sub..beta.-.gamma." are (CR.sup.CR.sup.D).sub.0-2,
(CH.sub.2).sub.0-2, (CH.sub.2).sub.0-5 mean that CR.sup.CR.sup.D is
present of number of 0 to 2, CH.sub.2 is present of number of 0 to
2, CH.sub.2 is present of number of 0 to 5, respectively.
[0080] In the present specification, the term "hemopathy" means
hemopathy accompanied with the unusual number of platelet, For
example the hemopathy is thrombocytopenia (after bone marrow
transplantation, after chemotherapy, anaplastic anemia, bone marrow
dysplasia syndrome, acquired thrombopenia of intractable sudden
thrombocy topenic purpura and the like, congenital thrombopenia of
thrombopoietin deficiency and the like) and the like, For example
this medicine can be used as treating agent in the case of
decreasing number of platelet by administrating antitumor agent, or
as protecting agent in the case of expecting the decrease of number
of platelet by administrating antitumor agent.
[0081] In the present specification, the term "modifying a platelet
production" means 1) increasing a number of platelet decreased by
administrating antitumor agent and the like. 2) maintaining a
number of platelet which may be decreased by administrating
antitumor agent and the like. 3) reducing the ratio of the platelet
number of decrease caused by administrating antitumor agent and the
like.
BRIEF DESCRIPTION OF THE DRAWING
[0082] FIG. 1: The chart shows the stimulation activity of a
present invention for the proliferation and differentiation of
megakaryocyte precursor cells, by counting megakaryocyte colonies
formed from human bone marrow cells.
[0083] FIG. 2: The chart represents proliferation of the human TPO
dependent cells bearing human TPO receptors by the present
invention compound, wherein the x-axis is concentration of the
present invention compound, and the y-axis is the absorbance as an
indicator of cell proliferation. Open circles indicate a response
of human TPO, and closed circles indicate a response of the
compound (B-1).
[0084] FIG. 3: The chart represents proliferation of the human TPO
independent cells bearing no human TPO receptor by the present
invention compound, wherein the x-axis is a concentration of the
present invention compound, and the y-axis is absorbance as an
indicator of cell proliferation. Open triangles indicate a response
of human TPO, and closed circles indicate a response of the
compound (B-1).
BEST MODE FOR CARRYING OUT THE INVENTION
[0085] Compounds (I) of the invention can be synthesized by the
following methods A to B and the similar process.
(Method A)
##STR00019##
[0086] wherein R.sup.1, R.sup.2, R.sup.3, and X are as defined
above mentioned.
(Step 1)
[0087] This step is a process of protecting of carboxylic acid of
4-formyl-substituted or 4-acyl-substituted benzoic acid derivatives
by R.sup.E. In step 3 combination of R.sup.E and R.sup.F is
important in order to remove selectively protecting group of two
carboxylic acid. In the case of RF is protecting group such as
methyl and ethyl, which can be removed by basic condition, it is
necessary that protecting group of R.sup.E can be removed by
another condition except basic condition. Examples of R.sup.E are
allyl (removed by palladium (0) complex), tert-butyl,
p-methoxybenzyl, triphenylmethyl, diphenylmethyl (removed by acidic
condition), trimethylsilylethyl, trimethylsilylethoxymethyl,
tert-butyldimethylsilyl (removed by fluoride ion) and the like.
[0088] Esterification condition can be used the method of reacting
with considerable halo-compound in the presence of suitable base.
And it can be synthesized by condensation reaction using a alcohol
derivative as starting material.
(Step 2)
[0089] This step is a process of converting aldehyde or ketone to
olefin, For examples, the olefin can be syntesized by the reaction
using phosphineylide such as Wittig reaction, Horner-Emmons
reaction, or by dehydrated condensation reaction such as
Knoevenagel reaction.
(Step 3)
[0090] This step is a process of removing the protecting group
R.sup.E. The removal of protecting group R.sup.E is carried out
under suitable reaction condition as described in Protective Groups
in Organic Synthesis, Theodora W Green (John Wiley & Sons).
(Step 4)
[0091] This step is a process of preparing amide derivative (VIII)
from carboxylic acid derivative (VII) and amine derivative
(X.sup.1--NH.sub.2) by the method such as active esterification,
acid chloride, mixed acid anhydride. This step is reacted in the
solvent such as tetrahydrofuran, dioxane, dichloromethane, toluene,
benzene. At active esterification method it can be carried out by
using 1-hydroxybenzotriazole, hydroxysuccinimide,
dimethylaminopyridine, and the like and dicyclohexylcarbodiimide,
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride salt,
and the like as condensation reagent. At acid halide method it can
be carried out by converting free carboxylic acid which is reacted
with thionyl chloride or oxalyl chloride to acid chloride. At mixed
acid anhydride method it can be carried out by converting
carboxylic acid which is reacted with ethylchloroformate,
isobutylchloroformate or the like to mixed acid anhydride.
Triethylamine, pyridine or the like are used as base in these
reaction according to be necessary.
(Step 5)
[0092] This step is a process of removing protecting group R.sup.F.
The protecting group R.sup.F is removed under suitable reaction
condition by using the method as described in Protective Groups in
Organic Synthesis, Theodora W Green (John Wiley & Sons).
(Step 6)
[0093] This step is a process of preparing amide derivative (I-A)
from carboxylic acid derivative (IX) and amine derivative
(R.sup.3--NH.sub.2) by the method such as active esterification,
acid chloride, mixed acid anhydride method. This step is reacted in
the solvent such as tetrahydrofuran, dioxane, dichloromethane,
toluene, benzene. At active esterification method it can be carried
out by using 1-hydroxybenzotriazole, hydroxysuccinimide,
dimethylaminopyridine, and the like and dicyclohexylcarbodiimide,
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride salt,
and the like as condensation reagent. At acid halide method it can
be carried out by converting free carboxylic acid which is reacted
with thionyl chloride or oxalyl chloride to acid chloride. At mixed
acid anhydride method it can be carried out by converting
carboxylic acid which is reacted with ethylchloroformate,
isobutylchloroformate or the like to mixed acid anhydride.
Triethylamine, pyridine or the like are used as base in these
reaction according to be necessary.
(Method B)
[0094] This method is another method for preparing compound (VIII)
as described method A.
##STR00020##
wherein R.sup.1, R.sup.2, and X.sup.1 are as defined above
mentioned.
(Step 1)
[0095] This step is a process of preparing carboamide derivative
(X.sup.1) in a manner similar to Step 4 of Method A.
(Step 2)
[0096] This step is a process of converting aldehyde derivative
(X.sup.1) to olefin derivative (XII) in a manner similar to Step 2
of Method A. Compound (XII) can be converted to compound (I-A) in a
manner similar to Step 5 and 6 of Method A.
[0097] A compound is represented by the formula wherein Y.sup.1 is
--N(-alkyl)-CO--; Z.sup.1 is optionally substituted thiazole or the
like:
##STR00021##
wherein W.sup.1 and Z.sup.1 are as defined above mentioned; Alk is
lower alkyl.
[0098] Under alkylation condition for preparing the above mentioned
compound may be obtained below mentioned compound.
##STR00022##
wherein W.sup.1, Z.sup.1 and Alk are as defined above
mentioned.
[0099] Compound in formula (I), (II) and (III) wherein a broken
line (---) represents the presence of a bond, contains cis-isomer,
trans-isomer and their mixture, For example, compound wherein
W.sup.1 is amide type possesses cis-isomer and trans-isomer blow
mentioned.
##STR00023##
wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X.sup.1, Y.sup.1, and
Z.sup.1 are as defined above mentioned.
[0100] The term "solvate" includes, for example, solvates with
organic solvents, hydrates, and the like.
[0101] The term "compound of the present invention" herein used
includes a pharmaceutically acceptable salt or solvate thereof. The
salt is exemplified by a salt with alkali metals (e.g., lithium,
sodium, potassium, and the like), alkaline earth metals (e.g.,
magnesium, calcium, and the like), ammonium, organic bases, amino
acids, mineral acids (e.g., hydrochloric acid, hydrobromic acid,
phosphoric acid, sulfuric acid, and the like), or organic acids
(e.g., acetic acid, citric acid, maleic acid, fumaric acid,
benzenesulfonic acid, p-toluenesulfonic acid, and the like). These
salts can be formed by the usual method. These hydrates can
coordinate with any water molecules when hydrates are formed.
[0102] Prodrug is a derivative of the compound having a group which
can be decomposed chemically or metabolically, and such prodrug is
a compound according to the present invention which becomes
pharmaceutically active by means of solvolysis or by placing the
compound in vivo under a physiological condition. The method of
both selection and manufacture of appropriate prodrug derivatives
is described in, for example. Design of Prodrugs, Elsevier,
Amsterdam, 1985), For instance, prodrugs such as an ester
derivative which is prepared by reacting a basal acid compound with
a suitable alcohol, or an amide derivative which is prepared by
reacting a basal acid compound with a suitable amine are
exemplified when the compounds according to present invention have
a carboxylic group. Particularly preferred esters as prodrugs are
methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl,
morpholinoethyl, and N,N-diethylglycolamido, and the like, For
instance, prodrugs such as an acyloxy derivative which is prepared
by reacting a basal hydroxy compound, with a suitable acyl halide
or a suitable acid anhydride, or an amide derivative which is
prepared by reacting a basal acid compound with a suitable amine
are exemplified when the compounds according to present invention
have a hydroxy group. Particularly preferred acyloxy derivatives as
prodrugs --OCOC.sub.2H.sub.5, --OCO(t-Bu), --OCOC.sub.15H.sub.31,
--OCO(m-COONa-Ph), --COCH.sub.2CH.sub.2COONa,
--OCOCH(NH.sub.2)CH.sub.3, --OCOCH.sub.2N(CH.sub.3).sub.2, and the
like, For instance, prodrugs such as an amide derivative which is
prepared by reacting a basal amino compound with a suitable acid
halide or a suitable acid anhydride are exemplified when the
compounds according to present invention have an amino group.
Particularly preferred amide as prodrugs are
--NHCO(CH.sub.2).sub.20CH.sub.3, --NHCOCH(NH.sub.2)CH.sub.3, and
the like.
[0103] The compound of the present invention is not restricted to
any particular isomers but includes all possible isomers and
racemic modifications.
[0104] The present invention compounds show excellent
thrombopoietin receptor agonism as described in examples mentioned
later, and may be used as a pharmaceutical composition (platelet
production modifier) for hemopathy accompanied with the unusual
number of platelet, for example thrombocytopenia and the like. And
the present compound may be used as a peripheral blood stem cell
releasing promoter, a differentiation-inducer of megakaryocytic
leukemic cell, a platelet increasing agent of a platelet donor and
the like.
[0105] When the compound of the present invention is administered
to a person for the treatment of the above diseases, it can be
administered orally as powder, granules, tablets, capsules,
pilulae, and liquid medicines, or parenterally as injections,
suppositories, percutaneous formulations, insufflation, or the
like. An effective dose of the compound is formulated by being
mixed with appropriate medicinal admixtures such as excipient,
binder, penetrant, disintegrators, lubricant, and the like if
necessary. Parenteral injections are prepared by sterilizing the
compound together with an appropriate carrier.
[0106] The dosage varies with the conditions of the patients,
administration route, their age, and body weight. In the case of
oral administration, the dosage can generally be between 0.1 to 100
mg/kg/day, and preferably 1 to 20 mg/kg/day for adult.
[0107] The following examples are provided to further illustrate
the present invention and are not to be constructed as limiting the
scope thereof.
[0108] Abbreviations described below are used in the following
examples.
Me: methyl Et: ethyl n-Pr: n-propyl i-Pr: isopropyl c-Pr:
cyclopropyl n-Bu: n-butyl i-Bu: i-butyl sec-Bu: sec-butyl t-Bu:
tert-butyl i-Bu: i-butyl n-Pen: n-pentyl c-Pen: cyclopentyl n-Hex:
n-hexyl c-Hex: cyclohexyl i-Hex: i-hexyl Ph: phenyl Bn: benzyl Bz:
benzoyl Py: pyridyl Th: thienyl Ac: acetyl Z: benzyloxycarbonyl
DMP: N,N-dimethylformamide
[0109] THF: tetrahydrofuran proppargyl, allyl, pyrazole,
pyrimidine, piperidine, methyl, cyclohexylmethyl
EXAMPLE
Example 1
[0110] The preparation of compound (A-1, A-2, and B-1)
##STR00024##
(Step 1)
[0111] A solution of terephthaladehydic acid (7.5 g), allyl bromide
(4.41 ml), and potassium carbonate (7.0 g) in DMF (100 ml) was
stirred at 60.degree. C. for 16 h. The reaction solvent was removed
under reduced pressure, and the residue was partitioned between
ethyl acetate and water. The ethyl acetate layer was washed with
sodium bicarbonate aqueous solution, water, and brine, and dried
over magnesium sulfate. The solvent was removed under reduced
pressure to obtain compound (2) 9.2 g as colorless clear oil.
[0112] .sup.1H NMR (CDCl.sub.3, .delta. ppm): 4.87 (2H, dt, J= 1.2,
5.7 Hz), 5.30-5.47 (2H, m), 5.99-6.12 (1H, m), 7.94-7.98 (2H, m),
8.20-8.25 (2H, m), 10.11 (1H, s).
(Step 2)
[0113] A solution of compound (2) (4.37 g) and ethyl
2-(triphenylphosphoranilidene)propionate (10.63 g) in toluene (100
ml) was heated with stirring at 70.degree. C. for 1 h. The reaction
solvent was concentrated to ca. 30 to 40 ml, the precipitated
triphenylphosphineoxide was filtered off. The filtrate was
concentrated, and the residue was purified by silica gel column
chromatography (ethyl acetate/n-hexane= 1/10) to obtain compound
(3) 6.9 g as colorless clear oil.
[0114] .sup.1H NMR (CDCl.sub.3, .delta. ppm): 1.36 (3H, t, J= 7.2
Hz), 2.11 (3H, d, J= 1.5 Hz), 4.29 (2H, q, J= 7.2 Hz), 4.84 (2H,
dt, J= 1.2, 5.7 Hz), 5.28-5.46 (2H, m), 5.98-6.11 (1H, m),
7.43-7.47 (2H, m), 7.69 (1H, d, J= 1.5 Hz), 8.06-8.10 (2H, m).
(Step 3)
[0115] A solution of compound (3) (6 g),
tetrakistriphenylphosphinpalladium (1.27 g), and morpholine (2.68
g) in THF (100 ml) was stirred at 60.degree. C. for 30 min. The
reaction solvent was concentrated to ca. 30 to 40 ml, and ethyl
acetate was added to the residue. The mixture was extracted with
sodium bicarbonate aqueous solution three times. The combined
sodium bicarbonate extract was acidified with 3M hydrochloric acid,
and the precipitated crystals were extracted with ethyl acetate.
The ethyl acetate layer was washed with brine, dried over magnesium
sulfate. The solvent was removed under reduced pressure to obtain
compound (4) 4.5 g as white crystals.
[0116] .sup.1H NMR (CDCl.sub.3, .delta. ppm): 1.37 (3H, t, J= 7.2
Hz), 2.13 (3H, d, J= 1.2 Hz), 4.30 (2H, q, J= 7.2 Hz), 7.49 (2H, d,
J= 8.4 Hz), 7.71 (1H, s), 8.14 (2H, d, J= 8.4 Hz).
(Step 4)
[0117] To a solution of compound (4) (5.67 g), oxalyl chloride (1.3
ml) in THF (100 ml) was added catalytic amount of DMF, and then the
reaction mixture was stirred at room temperature for 2 h. The
reaction solution was removed under reduced pressure, toluene was
added to the resulting residue, and toluene was removed under
reduced pressure. The obtained carboxylic acid chloride was
dissolved with dioxane (70 ml), was added 2-amino-4-(3,4-)
dichlorophenylythiazole (1 g), and pyridine (970 .mu.l) to the
mixture. The reaction solution was heated with stirring at
100.degree. C. for 16 h, and partitioned between ethyl acetate and
water. The ethyl acetate layer was washed with sodium bicarbonate
aqueous solution, water, and brine, and dried over magnesium
sulfate. The solvent was removed under reduced pressure to obtain
compound (A-1) 1.5 g as white crystals.
[0118] .sup.1H NMR (DMSO-d.sub.6, .delta. ppm): 1.29 (3H, t, J= 7.2
Hz), 2.10 (3H, d, J= 1.2 Hz), 4.23 (2H, q, J= 7.2 Hz), 7.62 7.68
(3H, m), 7.72 (1H, d, J= 8.4 Hz), 7.91 (1H, s), 7.94 (1H, dd, J=
1.8, 8.4 Hz), 8.15-8.20 (2H, m), 8.21 (1H, d, J= 1.8 Hz), 12.84
(1H, br).
(Step 5)
[0119] A solution of compound (A-1) (1.7 g), 4M sodium hydroxide
aqueous solution (5.5 ml) in THF (150 ml) was heated with stirring
85.degree. C. for 18 h. The reaction solution was acidified with
diluted hydrochloric acid, and the precipitated crystals were
filtered. The obtained powder was washed methanol and ethyl acetate
to obtain compound (A-2) (1.5 g) as white powder.
[0120] .sup.1H NMR (DMSO-de, .delta. ppm): 2.08 (3H, d, J= 0.9 Hz),
7.62-7.68 (3H, m), 7.72-(1H, cl, J= 8.7 Hz), 7.92 (1H, s), 7.95
(1H, dd, J= 2.1, 8.7 Hz), 8.16-8.20 (2H, m), 8.22 (1H, d, J= 1.8
Hz), 12.84 (1H, br).
(Step 6)
[0121] To a solution of compound (A-2) (690 mg), oxalyl chloride
(420 .mu.l) in THF (150 ml) was added catalytic amount of DMF, and
then the reaction solution was stirred at 70.degree. C. for 1 h.
The reaction solution was removed under reduced pressure, toluene
was added to the resulting residue, and toluene was removed under
reduced pressure. To the obtained carboxylic acid chloride was
added THF (100 ml), and cooled at ice-cooling. To a solution of 28%
ammonia aqueous solution (20 ml) was added ether and sodium
hydroxide (5 g) at ice-cooling, and stirred for 10 min, and
stranded. This ether solution was added to a THF solution of the
acid chloride, and stirred at ice-cooling for 1 h. The reaction
solution was partitioned between ethyl acetate and water. The
organic layer was successively washed with sodium bicarbonate
aqueous solution, water, and brine, and dried over magnesium
sulfate. The solvent was removed under reduced pressure, the
residue was purified by silica gel column chromatography (ethyl
acetate/n-hexane-10/1 to ethyl acetate) to obtain compound (B-1)
(400 mg) as colorless crystals.
[0122] .sup.1H NMR (DMSO-d.sub.6, .delta. ppm): 2.04 (3H, d, J= 1.5
Hz), 7.18 (1H, br), 7.32 (1H, s), 7.52-7.58 (2H, m), 7.60 (1H, br),
7.72 (1H, d, J= 8.1 Hz), 7.91 (1H, s), 7.94 (1H, dd. J= 2.1, 8.4
Hz), 8.14-8.19 (2H, m), 8.22 (1H, d, J= 2.4 Hz), 12.81 (1H,
br).
Example 2
The Preparation of Compound (A-7)
##STR00025##
[0123] (Step 1)
[0124] To a solution of 4-acetylbenzoic acid (1.64 g), oxalyl
chloride (1.31 ml) in THF (100 ml) was added catalytic amount of
DMF, and then the reaction mixture was stirred at room temperature
for 2 h. The reaction solution was removed under reduced pressure,
toluene was added to the resulting residue, and toluene was removed
under reduced pressure. To the obtained carboxylic acid chloride
was added THF (50 ml), tert-butyl alcohol (1.15 ml), and pyridine
(1.21 ml), and the reaction mixture was heated under reflux for 40
h, and partitioned between ice-water acidified with hydrochloric
acid and ethyl acetate. The ethyl acetate layer was washed with
sodium bicarbonate aqueous solution, water, and brine, and dried
over magnesium sulfate. The solvent was removed under reduced
pressure, the residue was purified by silica gel column
chromatography (ethyl acetate/n-hexane-175) to obtain compound (7)
(2.0 g) as white crystals.
[0125] .sup.1H NMR (CDCl.sub.3, .delta. ppm): 1.61 (9H, s), 2.64
(3H, s), 7.96-7.00 (2H, m), 8.04-8.09 (2H, m).
(Step 2)
[0126] To a suspension of 60% sodium hydride (360 mg) in THF (100
ml) was added 2-phosphonopropionic acid triethyl (2.14 g) at
ice-cooling. After the reaction mixture was stirred for 30 rain,
added dropwise a solution of compound (7) (1.9 g) in THF (15 ml) at
ice-cooling. The reaction solution was stirred at 50.degree. C. for
3 h, and partitioned between ice-water acidified with hydrochloric
acid and ethyl acetate. The ethyl acetate layer was washed with
sodium bicarbonate aqueous solution, water, and brine, and dried
over magnesium sulfate. The solvent was removed under reduced
pressure, the residue was purified by silica gel column
chromatography (ethyl acetate/n-hexane=1/15) to obtain compound (8)
(1.0 g) as a colorless oil.
[0127] .sup.1H NMR(CDCl.sub.3, .delta. ppm): 1.35 (3H, t, J=7.2
Hz), 1.60 (9H, s), 1.74 (3H, q, J=1.5 Hz), 2.24 (3H, q, J= 1.5 Hz),
4.27 (2H, q, J= 6.9 Hz), 7.18-7.22 (2H, m), 7.97-8.10 (2H, m).
(Step 3)
[0128] A solution of compound (8) (900 mg) in formic acid (98-100%,
10 ml) was stirred at room temperature for 3 h. The reaction
solution was concentrated, toluene was added to the residue, and
concentrated again. The obtained residue was washed with n-hexane
to obtain compound (9) (680 mg) as white crystals.
[0129] .sup.1H NMR (CDCl.sub.3, .delta. ppm): 1.36 (3H, t, J= 7.2
Hz), 1.74 (3H, q, J= 1.5 Hz), 2.26 (3H, q, J= 1.5 Hz), 4.28 (2H, q,
J= 7.2 Hz), 7.25-7.29 (2H, m), 8.10-8.14 (2H, m).
(Step 4)
[0130] Compound (A-7) was synthesized from compound (9) as starting
material in a manner similar to Step 4 of Example 1.
[0131] .sup.1H NMR (CDCl.sub.3, .delta. ppm): 1.36 (3H, t, J= 7.2
Hz), 1.74 (3H, q, J= 1.5 Hz), 2.25 (3H, q, J= 1.5 Hz), 4.28 (2H, q,
J= 7.2 Hz), 7.26-7.29 (2H, m), 7.44 (1H, d, J=8.4 Hz), 7.61 (1H,
dd, J= 2.1, 8.4 Hz), 7.91 (1H, d, J= 2.1 Hz), 7.91-7.95 (2H, m),
10.09 (1H, br).
[0132] Compound (A-3) to (A-6), (A-8) to (A-107), (B-2) to (B-46),
(C-1) to (C-5), (D-1), (E-1) to (E-2), (F-1) to (F-3), (G-1) to
(G-8), (H-1) to (H-8) and (I-1) to (I-6) were synthesized in a
manner similar to Example 1 and 2.
[0133] Their physical data of compound group A were shown in Tables
1 to 10, compound group B in Tables 11 to 17, compound group C in
Tables 18, compound group D in Tables 19, compound group E in
Tables 20, compound group F in Tables 21, compound group G in
Tables 22 to 23, compound group H in Tables 24 to 25, and compound
group I in Tables 26.
TABLE-US-00001 TABLE I ##STR00026## Com- pound No. R.sup.6 R.sup.1
R.sup.2 R.sup.5 .sup.1H-NMR (DMSO d-6) A-3 ##STR00027## H H Et 1.28
(3H, t. J = 7.2 Hz), 4.22 (2H, q, J = 7.2 Hz), 6.80 (1H, d, J =
16.5 Hz), 7.72 (1H, d, J = 8.4 Hz); 7.73 (1H, d, J = 15.9 Hz),
7.88-7.93 (3H, m), 7.94 (1H, dd, J = 2.1, 8.7 Hz), 8.12-8.18 (2H,
m), 8.21 (1H, d, J = 1.8 Hz), 12.84 (1H, s). A-4 ##STR00028## H H H
6.70 (1H, d, J = 15.9 Hz), 7.67 (1H, d, J = 15.9 Hz), 7.72 (1H, d,
J = 8.7 Hz), 7.84 (2H, m), 7.92 (1H, s), 7.95 (1H, dd, J = 1.8, 8.1
Hz), 8.12-8.18 (2H, m), 8.21 (1H, d, J = 2.1 Hz). 12.57 (1H, br),
12.84 (1H, s). A-5 ##STR00029## H Et Et 1.13 (3H, t, J = 7.2 Hz),
1.30 (3H, t, J = 7.2 Hz), 2.50 (2H, q, J = 7.2 Hz), 4.24 (2H, q, J
= 7.2 Hz), 7.577 (1H, s), 7.60-7.63 (2H, m), 7.72 (1H, d, J = 8.7
Hz), 7.92 (1H, s), 7.95 (1H, dd, J = 1.8, 8.4 Hz), 8.16-8.20 (2H,
m), 8.21 (1H, d, J = 1.8 Hz) 12.85 (1H, br). A-6 ##STR00030## H Et
H 1.13 (3H, t, J = 7.5 Hz), 2.47 (2H, q, J = 7.2 Hz), 7.55-7.60
(2H, m), 7.61 (1H, s), 7.72 (1H, d, J = 8.4 Hz), 7.91 (1H, s), 7.95
(1H, dd, J = 2.1, 8.4 Hz), 8.15-8.20 (2H, m), 8.21 (1H, d, J = 2.1
Hz), 12.76 (1H, br). A-8 ##STR00031## Me Me H 1.71 (3H, d, J = 1.5
Hz), 2.22 (3H, d, J = 1.2 Hz), 7.37-7.42 (2H, m), 7.73 (1H, d, J =
8.4 Hz), 7.92 (1H, s), 7.95 (1H, dd, J = 2.1, 8.4 Hz), 8.13-8.18
(2H, m), 8.22 (1H, d, J = 2.1 Hz), 12.77 (1H, br). A-9 ##STR00032##
H Me Et 1.29 (3H, t, J = 6.9 Hz), 2.10 (3H, d, J = 1.8 Hz), 4.23
(2H, q, J = 6.9 Hz), 7.48-7.57 (1H, m), 7.62- 7.68 (3H, m),
7.78-7.85 (2H, m), 7.93-8.10 (1H, m), 8.15-8.20 (2H, m), 12.85 (1H,
br). A-10 ##STR00033## H Me H 2.07 (3H, d, J = 1.5 Hz), 7.47-7.57
(1H, m), 7.62- 7.67 (3H, m), 7.79-7.85 (2H, m), 7.93-8.01 (1H, m),
8.15-8.20 (2H, m), 12.81 (1H, br). A-11 ##STR00034## H Cl Et 1.33
(3H, t, J = 7.2 Hz), 4.83 (2H, q, J = 7.2 Hz), 7.72 (1H, d, J = 8.1
Hz), 7.93 (3H, s), 7.94 (1H, dd, J = 2.1, 8.1 Hz), 8.04 (2H, d, J =
8.7 Hz), 8.08 (1H, s), 8.21 (1H, d, J = 2.4 Hz), 8.21 (2H, d, J =
8.7 Hz), 12.91 (1H, s). A-12 ##STR00035## H F Et 1.26 (3H, t, J =
7.5 Hz), 4.27 (2H, q, J = 7.5 Hz), 6.91 (1H, d, J = 21 Hz), 7.22
(1H, s), 7.42 (1H, d, J = 8.1 Hz), 7.55 (2H, d, J = 8.1 Hz), 7.69
(1H, dd, J = 1.8 Hz, 8.1 Hz), 7.87 (1H, d, J = 2.1 Hz), 7.87 (2H,
d, J = 8.1 Hz), 10.15 (1H, s)
TABLE-US-00002 TABLE 2 Com- pound No. R.sup.6 R.sup.1 R.sup.2
R.sup.5 .sup.1H-NMR (DMSO d-6) A-13 ##STR00036## H NH Z Me 3.64
(1H, s), 5.12 (2H, s), 6.55 (1H, s), 7.32 (2H, d, J = 8.4 Hz),
7.35-7.42 (5H, m), 7.72 (1H, d, J = 8.7 Hz), 7.94 (1H, dd, J = 1.8
Hz, 8.7 Hz), 8.06 (2H, d, J = 8.4 Hz), 8.21 (1H, d, J = 1.8 Hz),
9.39 (1H, s), 9.39 (1H, s), 12.86 (1H, s) A-14 ##STR00037## H Cl H
7.73 (1H, d, J = 8.4 Hz), 7.94 (1H, s), 7.95 (1H, dd, J = 2.1, 8.4
Hz), 8.04 (2H, d, J = 8.1. Hz), 8.05 (1H, s), 8.21 (2H, d, J = 8.1
Hz), 8.22 (1H, d, J = 2.1 Hz), 12.90 (1H, s), 13.84 (1H, bs) A-15
##STR00038## H Br Me 3.55 (3H, s), 6.84 (1H, s), 7.56 (2H, d, J =
8.4 Hz), 7.72 (1H, d, J = 8.1 Hz), 7.93 (1H, s), 7.95 (1H, dd, J =
8.4, 2.1 Hz), 8.15 (2H, d, J = 8.4 Hz), 8.22 (1H, d, J = 2.1 Hz),
12.90 (1H, s) A-16 ##STR00039## H Br H 6.72 (1H, s), 7.58 (2H, d, J
= 8.4 Hz), 7.72 (1H, d, J = 8.4 Hz), 7.93 (1H, s), 7.95 (1H, dd, J
= 8.4 Hz, 1.8 Hz), 8.12 (2H, d, J = 8.4 Hz), 8.22 (1H, d, J = 2.4
Hz), 12.97 (1H, s), 13.97 (1H, bs) A-17 ##STR00040## H Me Et
7.15-7.21 (1H, m), 7.26-7.84 (6H, m), 7.47- 7.54 (1H, m), 7.87 (1H,
s), 8.24 (2H, d, J = 8.5 Hz), 12.97 (1H, s), 13.97 (1H, bs) A-18
##STR00041## H Me H 2.07 (3H, d, J = 1.4 Hz), 7.12-7.21 (1H, m),
7.47- 7.54 (1H, m), 7.64 (2H, d, J = 8.5 Hz), 7.66 (1H, s),
7.74-7.78 (1H, m), 7.80-7.84 (1H, m), 7.85 (1H, s), 8.18 (2H, d, J
= 8.5 Hz), 12.63 (1H, bs), 12.85 (1H, s) A-19 ##STR00042## H Me Et
1.30 (3H, t, J = 7.1 Hz), 2.10 (3H, d, J = 1.4 Hz), 4.23 (2H, q, J
= 7.1 Hz), 7.33-7.36 (1H, m), 7.58 (1H, t, J = 8.0 Hz), 7.65 (2H,
d, J = 8.5 Hz), 7.67 (1H, s), 7.91 (1H, s), 7.93 (1H, bs),
7.99-8.02 (1H, m), 8.19 (2H, d, J = 8.5 Hz), 12.85 (1H, s) A-20
##STR00043## H Me H 2.07 (3H, d, J = 1.4 Hz), 7.33-7.36 (1H, m),
7.57- 7.66 (4H, m), 7.91 (1H, s), 7.94 (1H, m), 7.99- 8.02 (1H, m),
8.18 (2H, d, J = 8.5 Hz), 12.68 (1H, bs), 12.85 (1H, s) A-21
##STR00044## H Me Et 1.29 (3H, t, J = 7.1 Hz), 2.10 (3H, d, J = 1.7
Hz), 3.89 (3H, s), 4.23 (2H, q, J = 7.1 Hz), 7.22-7.28 (1H, m),
7.63-7.66 (4H, m), 7.74-7.80 (2H, m), 8.18 (2H, d, J = 8.5 Hz),
12.80 (1H, bs) A-22 ##STR00045## H Me H 2.07 (3H, d, J = 1.4 Hz),
3.89 (3H, s), 7.22-7.28 (1H, m), 7.63-7.67 (4H, m), 7.75-7.81 (2H,
m), 8.18 (2H, d, J = 8.5 Hz), 12.80 (1H, bs) A-23 ##STR00046## H Me
Et 1.29 (3H, t, J = 7.1 Hz), 2.10 (3H, d, J = 1.7 Hz), 4.23 (2H, q,
J = 7.1 Hz), 7.26-7.32 (4H, m), 7.63- 7.66 (3H, m), 7.69 (1H, s),
7.97-8.02 (2H, m), 8.18 (2H, d, J = 8.5 Hz), 12.83 (1H, bs) A-24
##STR00047## H Me H 2.08 (3H, d, J = 1.1 Hz), 7.26-7.32 (2H, m),
7.64 (2H, d, J = 8.5 Hz), 7.06 (1H, s), 7.704 (1H, s), 7.98-8.03
(2H, m), 8.18 (2H, d, J = 8.5 Hz), 12.85 (1H, bs)
TABLE-US-00003 TABLE 3 Compound No. R.sup.6 R.sup.1 R.sup.2 R.sup.5
.sup.1H-NMR (DMSO d-6) A-25 ##STR00048## H Me Et 1.29 (3 H, t, J =
7.1 Hz), 2.10 (3 H, d, J = 1.4 Hz), 4.23 (2 H, q, J = 7.1 Hz),
7.64-7.67 (3 H, m), 7.83 (2 H, d, J = 8.5 Hz), 7.95 (1 H, s),
8.17-8.20 (4 H, m), 12.93 (1 H, bs) A-26 ##STR00049## H Me H 2.07
(3 H, d, J = 1.1 Hz), 7.65 (2 H, d, J = 8.2 Hz), 7.66 (1 H, s),
7.83 (2 H, d, J = 8.5 Hz), 7.96 (1 H, s), 8.17 (2 H, d, J = 8.2
Hz), 8.18 (2 H, d, J = 8.5 Hz), 12.93 (1 H, s) A-27 ##STR00050## H
Me Et 1.29 (3 H, t, J = 7.1 Hz), 2.10 (3 H, d, J = 1.4 Hz), 4.23 (2
H, q, J = 7.1 Hz), 7.64-7.72 (5 H, m), 7.97 (1 H, s), 8.19 (2 H, d,
J = 8.5 Hz), 8.25-8.28 (1 H, m), 8.33 (1 H, s), 12.80 (1 H, bs)
A-28 ##STR00051## H Me H 2.08 (3 H, d, J = 1.1 Hz), 7.68 (2 H, d, J
= 8.2 Hz), 7.66 (1 H, s), 7.71 (1 H, d, J = 5.2 Hz), 7.91 (1 H, s),
8.18 (2 H, d, J = 8.2 Hz), 8.26-8.28 (1 H, m), 8.33 (1 H, bs),
12.87 (1 H, s) A-29 ##STR00052## H Cl Et 1.33 (3 H, t, J = 7.1 Hz),
4.32 (2 H, q, J = 7.1 Hz), 7.15-7.21 (1 H, m), 7.47-7.54 (1 H, m),
7.81- 7.83 (1 H, m), 7.86 (1 H, s), 8.05 (2 H, d, J = 8.5 Hz), 8.09
(1 H, s), 8.22 (2 H, d, J = 8.5 Hz), 12.92 (1 H, bs) A-30
##STR00053## H Cl H 7.16-7.21 (1 H, m), 7.47-7.54 (1 H, m), 7.75-
7.78 (1 H, m), 7.81-7.84 (1 H, m), 7.86 (1 H, s), 8.04 (2 H, d, J =
8.2 Hz), 8.06 (1 H, s), 8.21 (2 H, d, J = 8.2 Hz), 12.91 (1 H, s)
A-31 ##STR00054## H Cl Et 1.33 (3 H, t, J = 7.1 Hz), 4.33 (2 H, q,
J = 7.1 Hz), 7.34-7.36 (1 H, m), 7.57-7.63 (1 H, m), 7.92 (1 H, s),
7.94 (1 H, s), 7.99-8.02 (1 H, m), 8.05 (2 H, d, J = 8.5 Hz), 8.08
(1 H, s), 8.22 (2 H, d, J = 8.5 Hz), 12.92 (1 H, bs) A-32
##STR00055## H Cl H 7.33-7.36 (1 H, m), 7.57-7.63 (1 H, m), 7.93 (1
H, s), 7.93 (1 H, m), 8.04-8.06 (4 H, m), 8.21 (2 H, d, J = 8.2
Hz), 12.92 (1 H, s) A-33 ##STR00056## H Cl Et 1.33 (3 H, t, J = 7.1
Hz), 3.88 (3 H, s), 4.33 (2 H, q, J = 7.1 Hz), 7.22-7.28 (1 H, m),
7.67 (1 H, s), 7.74- 7.80 (2 H, m), 8.05 (2 H, d, J = 8.5 Hz), 8.09
(1 H, s), 8.21 (2 H, d, J = 8.5 Hz), 12.88 (1 H, bs) A-34
##STR00057## H Cl H 3.89 (3 H, s), 7.22-7.28 (1 H, m), 7.67 (1 H,
s), 7.76-7.81 (2 H, m), 8.04 (2 H, d, J = 8.5 Hz), 8.05 (1 H, s),
8.21 (2 H, d, J = 8.5 Hz), 12.87 (1 H, bs) A-35 ##STR00058## H Cl
Et 1.33 (3 H, t, J = 7.1 Hz), 4.32 (2 H, q, J = 7.1 Hz), 7.48-7.57
(1 H, m), 7.80-7.85 (1 H, m), 7.83 (1 H, s), 7.94-8.01 (1 H, m),
8.05 (2 H, d, J = 8.5 Hz), 8.08 (1 H, s), 8.21 (2 H, d, J = 8.5
Hz), 12.91 (1 H, bs) A-36 ##STR00059## H Cl H 7.48-7.58 (1 H, m),
7.80-7.85 (1 H, m), 7.83 (1 H, s), 7.94-8.01 (1 H, m), 8.04 (2 H,
d, J = 8.5 Hz), 8.05 (1 H, s), 8.21 (2 H, d, J = 8.5 Hz), 12.92 (1
H, bs)
TABLE-US-00004 TABLE 4 Compound No. R.sup.6 R.sup.1 R.sup.2 R.sup.5
.sup.1H-NMR (DMSO d-6) A-37 ##STR00060## H Cl Et 1.33 (3 H, t, J =
7.1 Hz), 4.32 (2 H, q, J = 7.1 Hz), 7.26-7.32 (2 H, m), 7.71 (1 H,
s), 7.98-8.02 (2 H, m), 8.04 (2 H, d, J = 8.5 Hz), 8.09 (1 H, s),
8.21 (2 H, d, J = 8.5 Hz), 12.91 (1 H, bs) A-38 ##STR00061## H Cl H
7.26-7.33 (2 H, m), 7.72 (1 H, s), 7.98-8.03 (2 H, m), 8.04 (2 H,
d, J = 8.5 Hz), 8.05 (1 H, s), 8.21 (2 H, d, J = 8.5 Hz), 12.92 (1
H, bs) A-39 ##STR00062## H Cl Et 1.33 (3 H, t, J = 7.1 Hz), 4.32 (2
H, q, J = 7.1 Hz), 7.83 (2 H, d, J = 8.4 Hz), 7.97 (1 H, s), 8.05
(2 H, d, J = 8.5 Hz), 8.09 (1 H, s), 8.18 (2 H, d, J = 8.4 Hz),
8.22 (2 H, d, J = 8.5 Hz), 13.00 (1 H, s) A-40 ##STR00063## H Cl H
7.83 (2 H, d, J = 8.5 Hz), 7.96 (1 H, s), 8.04 (2 H, d, J = 8.5
Hz), 8.06 (1 H, s), 8.18 (2 H, d, J = 8.5 Hz), 8.22 (2 H, d, J =
8.5 Hz), 12.97 (1 H, bs) A-41 ##STR00064## H Cl Et 1.33 (3 H, t, J
= 7.1 Hz), 4.33 (2 H, q, J = 7.1 Hz), 7.70-7.72 (2 H, m), 7.98 (1
H, s), 8.05 (2 H, d, J = 8.5 Hz), 8.09 (1 H, s), 8.22 (2 H, d, J =
8.5 Hz), 8.25-8.28 (1 H, m), 8.33 (1 H, bs), 12.92 (1 H, s) A-42
##STR00065## H Cl H 7.70-7.72 (2 H, m), 7.98 (1 H, s), 8.04 (2 H,
d, J = 8.5 Hz), 8.06 (1 H, s), 8.22 (2 H, d, J = 8.5 Hz), 8.24-8.28
(1 H, m), 8.33 (1 H, bs), 12.92 (1 H, bs) A-43 ##STR00066## H F H
7.15 (1 H, d, J = 36.3 Hz), 7.73 (1 H, d, J = 8.4 Hz), 7.86 (2 H,
d, J = 8.7 Hz), 7.97-7.94 (2 H, m), 8.18 (2 H, d, J = 8.4 Hz), 8.22
(1 H, d, J = 2.1 Hz), 12.89 (1 H, s) A-44 ##STR00067## H F H 7.20
(1 H, d, J = 23.1 Hz), 7.68 (2 H, d, J = 8.5 Hz), 7.70 (1 H, s),
7.97 (1 H, s), 8.12 (2 H, d, J = 8.5 Hz), 8.25-8.28 (1 H, m), 8.33
(1 H, bs), 12.84 (1 H, bs) A-45 ##STR00068## H F H 7.19 (1 H, d, J
= 22.8 Hz), 7.33-7.56 (1 H, m), 7.57-7.63 (1 H, m), 7.68 (2 H, d, J
= 8.5 Hz), 7.91 (1 H, s), 7.94 (1 H, bs), 7.99-8.02 (1 H, m), 8.11
(2 H, d, J = 8.5 Hz), 12.83 (1 H, bs) A-46 ##STR00069## H F H 7.20
(1 H, d, J = 22.9 Hz), 7.68 (2 H, d, J = 8.5 Hz), 7.83 (2 H, d, J =
8.5 Hz), 7.96 (1 H, s), 8.12 (2 H, d, J = 8.5 Hz), 8.18 (2 H, d, J
= 8.5 Hz), 12.91 (1 H, s), 13.87 (1 H, bs) A-47 ##STR00070## H Cl H
7.39-7.45 (1 H, m), 7.48-7.54 (2 H, m), 7.67- 7.73 (3 H, m),
7.77-7.81 (2 H, m), 8.03-8.07 (3 H, m), 8.19-8.25 (3 H, m) A-48
##STR00071## H Cl H 1.32 (9 H, s), 7.47 (2 H, d, J = 9.0 Hz), 7.64
(1 H, s), 7.89 (2 H, d, J = 9.0 Hz), 8.01-8.06 (3 H, m), 8.22 (2 H,
d, J = 8.1 Hz), 12.89 (1 H, s), 13.90 (1 H, bs) A-49 ##STR00072## H
Cl H 0.87 (3 H, t, J = 7.2 Hz), 1.26-1.36 (4 H, m), 1.60 (2 H,
quint, J = 7.8 Hz), 2.60 (2 H, t, J = 7.5 Hz), 7.27 (2 H, d, J =
8.4 Hz), 7.64 (1 H, s), 7.87 (2 H, d, J = 8.1 Hz), 8.02-8.05 (3 H,
m), 8.21 (2 H, d, J = 8.4 Hz), 12.88 (1 H, s), 13.79 (1 H, bs)
TABLE-US-00005 TABLE 5 Compound No. R.sup.6 R.sup.1 R.sup.2 R.sup.5
.sup.1H-NMR (DMSO d-6) A-50 ##STR00073## H Cl H 7.30-7.46 (3 H, m),
7.63 (1 H, d, J = 2.4 Hz), 8.03- 8.07 (3 H, m), 8.12 (1 H, td, J =
1.8 Hz, 7.8 Hz), 8.22 (2 H, d, J = 8.7 Hz), 12.93 (1 H, s), 13.85
(1 H, bs) A-51 ##STR00074## H Cl H 7.19-7.28 (2 H, m), 7.47-7.57 (2
H, m), 8.01- 8.05 (3 H, m), 8.21 (2 H, d, J = 8.4 Hz), 12.97 (1 H,
s), 13.80 (1 H, bs) A-52 ##STR00075## H Cl H 3.82 (3 H, s),
6.89-6.94 (1 H, m), 7.36 (1 H, t, J = 8.1 Hz), 7.53-7.56 (2 H, m),
7.75 (1 H, s), 8.02- 8.06 (3 H, m), 8.21 (2 H, d, J = 8.4 Hz),
12.88 (1 H, s), 13.82 (1 H, bs) A-53 ##STR00076## H Cl H 6.60 (1 H,
dd, J = 1.8 Hz, 3.3 Hz), 6.75 (1 H, d, J = 3.3 Hz), 7.44 (1 H, s),
7.75 (1 H, d, J = 1.8 Hz), 8.01-8.04 (3 H, m), 8.21 (2 H, d, J =
8.7 Hz) A-54 ##STR00077## H Cl H 7.37 (1 H, m), 7.49-7.58 (3 H, m),
7.65 (1 H, dt, J = 1.8 Hz, 8.1 Hz), 7.71-7.76 (2 H, m), 7.88 (1 H,
s), 7.97 (1 H, dt, J = 1.8 Hz, 7.5 Hz), 8.03-8.06 (3 H, m), 8.23 (2
H, d, J = 7.8 Hz), 8.28 (1 H, t, J = 1.8 Hz), 12.90 (1 H, s), 13.82
(1 H, bs) A-55 ##STR00078## H Cl H 0.92 (3 H, t, J = 7.5 Hz), 1.34
(2 H, sext, J = 7.5 Hz), 1.60 (2 H, quint, J = 7.5 Hz), 2.64 (2 H,
t, J = 7.5 Hz), 7.17 (1 H, d, J = 7.8 Hz), 7.35 (1 H, t, J = 7.5
Hz), 7.70 (1 H, s), 7.76 (1 H, d, J = 7.8 Hz), 7.81 (1 H, s),
8.02-8.05 (3 H, m), 8.22 (2 H, d, J = 8.4 Hz) 12.86 (1 H, s), 13.84
(1 H, bs) A-56 ##STR00079## H Cl H 7.24 (1 H, dt, J = 5.8 Hz, 2.5
Hz), 7.40 (1 H, ddd, J = 11.9 Hz, 9.4 Hz, 2.5 Hz), 7.59 (1 H, d, J
= 2.5 Hz), 8.04 (2 H, d, J = 8.5 Hz), 8.05 (1 H, s), 8.09-8.20 (1
H, m), 8.21 (2 H, d, J = 8.5 Hz), 12.93 (1 H, s), 13.82 (1 H, bs)
A-57 ##STR00080## H Cl H 7.55 (1 H, t, J = 8.0 Hz), 7.77-781 (2 H,
m), 8.04 (2 H, d, J = 8.5 Hz), 8.06 (1 H, s), 8.22 (2 H, d, J = 8.5
Hz), 8.37-8.42 (1 H, m), 12.99 (1 H, s), 13.85 (1 H, bs) A-58
##STR00081## H Cl H 7.22-7.30 (1 H, m), 7.37-7.46 (1 H, m), 7.72 (1
H, d, J = 2.5 Hz), 8.04 (2 H, d, J = 8.5 Hz), 8.05 (1 H, s), 8.21
(2 H, d, J = 8.5 Hz), 12.92 (1 H, s), 13.82 (1 H, bs) A-59
##STR00082## H Cl H 0.92-0.97 (3 H, m), 1.41-1.49 (2 H, m), 1.67-
1.75 (2 H, m), 4.01 (2 H, t, J = 6.3 Hz), 7.00 (2 H, d, J = 8.5
Hz), 7.54 (1 H, s), 7.87 (2 H, d, J = 8.5 Hz), 8.04 (2 H, d, J =
8.5 Hz), 8.05 (1 H, s), 8.21 (2 H, d, J = 8.5 Hz), 12.85 (1 H, s),
13.76 (1 H, bs) A-60 ##STR00083## H Cl H 7.74-7.76 (1 H, m), 7.82
(1 H, d, J = 2.7 Hz), 7.80- 7.84 (1 H, m), 8.03-8.05 (3 H, m), 8.22
(2 H, d, J = 8.5 Hz), 8.31 (1 H, t, J = 7.6 Hz), 13.01 (1 H, s),
13.79 (1 H, bs) A-61 ##STR00084## H Cl H 3.83 (3 H, s), 6.91-6.98
(2 H, m), 7.45 (1 H, d, J = 2.5 Hz), 8.00 (4 H, m), 8.21 (2 H, d, J
= 8.5 Hz), 12.88 (1 H, s), 13.81 (1 H, bs)
TABLE-US-00006 TABLE 6 Compound No. R.sup.6 R.sup.1 R.sup.2 R.sup.5
.sup.1H-NMR (DMSO d-6) A-62 ##STR00085## H Cl H 7.68 (1 H, d, J =
2.5 Hz), 7.68-7.76 (1 H, m), 7.80- 8.07 (4 H, m), 8.20 (2 H, d, J =
8.5 Hz), 12.92 (1 H, s) A-63 ##STR00086## H Cl H 7.48 (1 H, t, J =
8.8 Hz), 7.85 (1 H, s), 7.98-8.03 (1 H, m), 8.04 (2 H, d, J = 8.5
Hz), 8.05 (1 H, s), 8.21 (2 H, d, J = 8.5 Hz), 8.30 (1 H, dd, J =
6.9 Hz, 2.2 Hz), 12.88 (1 H, s), 13.82 (1 H, bs) A-64 ##STR00087##
H Cl H 0.89 (6 H, d, J = 6.7 Hz), 1.87 (1 H, seven, J = 6.7 Hz),
2.48 (2 H, d, J = 7.3 Hz), 7.23 (2 H, d, J = 8.2 Hz), 7.64 (1 H,
s), 7.87 (2 H, d, J = 8.2 Hz), 8.04 (2 H, d, J = 8.5 Hz), 8.05 (1
H, s), 8.21 (2 H, d, J = 8.5 Hz), 12.88 (1 H, s), 13.79 (1 H, bs)
A-65 ##STR00088## H Cl H 8.02-8.05 (4 H, m), 8.05 (1 H, s), 8.22 (2
H, d, J = 8.5 Hz), 8.27 (1 H, s), 8.64 (2 H, s), 12.94 (1 H, s),
13.84 (1 H, bs) A-66 ##STR00089## H Cl H 3.86 (3 H, s), 7.17 (1 H,
t, J = 7.5 Hz), 7.25 (1 H, t, J = 7.5 Hz), 7.38 (1 H, s), 7.50 (1
H, d, J = 8.4 Hz), 7.78 (1 H, s), 8.03-8.06 (3 H, m), 8.17 (1 H, d,
J = 7.8 Hz), 8.22 (2 H, d, J = 8.4 Hz), 12.79 (1 H, bs) A-67
##STR00090## H Cl H 2.85 (6 H, s), 3.52 (2 H, t, J = 5.4 Hz), 4.41
(2 H, t, J = 5.4 Hz), 7.09 (2 H, d, J = 8.7 Hz), 7.60 (1 H, s),
7.93 (2 H, d, J = 8.7 Hz), 8.01-8.05 (3 H, m), 8.21 (2 H, d, J =
8.7 Hz), 12.84 (1 H, bs) A-68 ##STR00091## H F H 7.15 (1 H, d, J =
36 Hz), 7.24-7.33 (2 H, m), 7.70 (1 H, s), 7.86 (2 H, d, J = 8.4
Hz), 7.96-8.03 (2 H, m), 8.18 (2 h, d, J = 8.7 Hz), 12.86 (1 H, s)
A-69 ##STR00092## H Cl H 7.57 (1 H, dd, J = 8.7 Hz, 1.8 Hz), 7.67
(1 H, d, J = 2.4 Hz), 7.70 (1 H, dd, J = 11.4 Hz, 2.1 Hz), 8.02-
8.09 (4 H, m), 8.21 (2 H, d, J = 8.7 Hz), 12.97 (1 H, s), 13.69 (1
H, bs) A-70 ##STR00093## H Cl H 2.36 (3 H, s), 7.13-7.19 (2 H, m),
7.54-7.55 (1 H, m), 7.98-8.06 (4 H, m), 8.22 (2 H, d, J = 8.4 Hz),
12.89 (1 H, s), 13.80 (1 H, bs) A-71 ##STR00094## H Cl H 7.39-7.45
(1 H, m), 7.51 (2 H, t, J = 7.8 Hz), 7.67- 7.72 (3 H, m), 7.79 (2
H, d, J = 8.4 Hz), 8.03-8.07 (3 H, m), 8.19-8.25 (3 H, m), 12.97 (1
H, s), 13.86 (1 H, bs) A-72 ##STR00095## H Cl H 7.30-7.48 (2 H, m),
7.72 (1 H, d, J = 2.4 Hz), 7.88- 7.93 (1 H, m), 8.04 (2 H, d, J =
8.5 Hz), 8.05 (1 H, s), 8.22 (2 H, d, J = 8.5 Hz), 12.96 (1 H, s),
13.83 (1 H, bs) A-73 ##STR00096## H Cl H 2.00-2.10 (2 H, m),
2.86-2.94 (4 H, m), 7.29 (1 H, d, J = 7.7 Hz), 7.61 (1 H, s),
7.72-7.75 (1 H, m), 7.82 (1 H, s), 8.04 (2 H, d, J = 8.5 Hz), 8.05
(1 H, s), 8.21 (2 H, d, J = 8.5 Hz), 12.84 (1 H, s), 13.84 (1 H,
bs)
TABLE-US-00007 TABLE 7 Compound No. R.sup.6 R.sup.1 R.sup.2 R.sup.5
.sup.1H-NMR (DMSO d-6) A-74 ##STR00097## H Cl H 3.24 (2 H, t, J =
8.5 Hz), 4.57 (2 H, t, J = 8.8 Hz), 6.83 (1 H, d, J = 8.2 Hz), 7.49
(1 H, s), 7.73 (1 H, dd, J = 8.2 Hz, 1.6 Hz), 7.82 (1 H, s), 8.04
(2 H, d, J = 8.5 Hz), 8.05 (1 H, s), 8.20 (2 H, d, J = 8.5 Hz),
12.83 (1 H, bs) A-75 ##STR00098## H Cl H 7.51 (1 H, t, J = 9.1 Hz),
7.86 (1 H, s), 7.95-8.00 (1 H, m), 8.04 (2 H, d, J = 8.5 Hz), 8.05
(1 H, s), 8.16 (1 H, dd, J = 7.4 Hz, 2.2 Hz), 8.22 (2 H, d, J = 8.5
Hz), 12.90 (1 H, bs) A-76 ##STR00099## H Cl H 7.46 (2 H, d, J = 8.8
Hz), 7.72 (1 H, s), 8.04 (2 H, d, J = 8.5 Hz), 8.06 (1 H, s), 8.09
(2 H, d, J = 8.8 Hz), 8.22 (2 H, d, J = 8.5 Hz), 12.96 (1 H, s),
13.86 (1 H, bs) A-77 ##STR00100## H Cl H 7.76 (1 H, d, J = 2.4 Hz),
7.81-7.91 (1 H, m), 8.03 (2 H, d, J = 8.5 Hz), 8.04 (1 H, s), 8.20
(2 H, d, J = 8.5 Hz), 12.95 (1 H, s), 13.81 (1 H, s) A-78
##STR00101## H Cl H 2.52 (3 H, s), 7.34 (2 H, d, J = 8.5 Hz), 7.69
(1 H, s), 7.91 (2 H, d, J = 8.5 Hz), 8.04 (2 H, d, J = 8.8 Hz),
8.06 (1 H, s), 8.21 (2 H, d, J = 8.5 Hz), 12.91 (1 H, bs) A-79
##STR00102## H Cl H 7.58-7.64 (1 H, m), 7.79 (1 H, d, J = 2.5 Hz),
7.79- 7.83 (1 H, m), 8.04 (2 H, d, J = 8.5 Hz), 8.06 (1 H, s), 8.22
(2 H, d, J = 8.5 Hz), 8.52 (1 H, dd, J = 6.9 Hz, 2.2 Hz), 12.93 (1
H, s), 13.72 (1 H, bs) A-80 ##STR00103## H Cl H 7.39-7.55 (5 H, m),
7.56-7.62 (2 H, m), 8.05 (2 H, d, J = 8.5 Hz), 8.06 (1 H, s), 8.13
(1 H, td, J = 7.8 Hz, 1.8 Hz), 8.23 (2 H, d, J = 8.5 Hz), 12.96 (1
H, s), 13.82 (1 H, bs) A-81 ##STR00104## H Cl H 7.30 (1 h, t, J =
8.1 Hz), 7.68-7.74 (2 H, m), 8.02- 8.05 (3 H, m), 8.10 (1 H, td, J
= 7.8 Hz, 1.8 Hz), 8.21 (2 H, d, J = 8.7 Hz), 12.96 (1 H, s), 13.82
(1 h, bs) A-82 ##STR00105## H Cl H 3.89 (2 H, s), 7.14-7.27 (2 H,
m), 7.60-7.68 (2 H, m), 8.02-8.06 (3 H, m), 8.21 (2 H, d, J = 8.4
Hz), 12.92 (1 H, s), 13.80 (1 H, bs) A-83 ##STR00106## H Cl H 2.32
(3 H, d, J = 1.8 Hz), 7.21 (1 H, t, J = 7.5 Hz), 7.25-7.31 (1 H,
m), 7.61 (1 H, d, J = 2.7 Hz), 7.94 (1 H, td, J = 7.5 Hz, 1.8 Hz),
8.02-8.06 (3 H, m), 8.21 (2 H, d), 12.91 (1 H, s), 13.80 (1 H, bs)
A-84 ##STR00107## H Cl H 0.84-0.90 (3 H, m), 1.30-1.37 (4 H, m),
1.56- 1.66 (2 H, m), 2.68 (2 H, t, J = 7.3 Hz), 7.20-7.30 (2 H, m),
7.61 (1 H, d, J = 2.7 Hz), 7.95 (1 H, td, J = 7.3 Hz, 2.1 Hz), 8.04
(2 H, d, J = 8.5 Hz), 8.06 (1 H, s), 8.21 (2 H, d, J = 8.5 Hz),
12.88 (1 H, s), 13.89 (1 H, bs)
TABLE-US-00008 TABLE 8 Compound No. R.sup.6 R.sup.1 R.sup.2 R.sup.5
.sup.1H-NMR (DMSO d-6) A85 ##STR00108## H Cl H 0.86-0.90 (3 H, m),
1.30-1.37 (4 H, m), 1.56- 1.66 (2 H, m), 2.65 (2 H, t, J = 7.6 Hz),
7.18-7.24 (1 H, m), 7.69 (1 H, s), 7.79-7.84 (1 H, m), 7.87- 7.91
(1 H, m), 8.03 (2 H, d, J = 8.5 Hz), 8.06 (1 H, s), 8.22 (2 H, d, J
= 8.5 Hz), 12.92 (1 H, s), 14.00 (1 H, bs) A-86 ##STR00109## H Cl H
7.28 (1 H, td, J = 9.1 Hz, 1.8 Hz), 7.64 (1 H, s), 7.81-7.89 (1 H,
m), 8.04 (2 H, d, J = 8.5 Hz), 8.05 (1 H, s), 8.20 (2 H, d, J = 8.5
Hz), 13.01 (1 H, s), 13.93 (1 H, bs) A-87 ##STR00110## H Cl H 2.31
(3 H, s), 2.41 (3 H, s), 7.08 (1 H, dd, J = 7.7 Hz, 1.4 Hz), 7.18
(1 H, d, J = 7.7 Hz), 7.33 (1 H, s), 7.49 (1 H, d, J = 1.4 Hz),
8.05 (2 H, d, J = 8.5 Hz), 8.20 (2 H, d, J = 8.5 Hz), 12.85 (1 H,
bs) A-88 ##STR00111## H Cl H 7.31-7.44 (3 H, m), 7.49 (td, J = 7.5
Hz, 1.8 Hz), 7.62-7.68 (3 H, m), 8.03-8.06 (3 H, m), 8.12 (1 H, td,
J = 7.5 Hz, 1.8 Hz), 8.22 (2 H, d, J = 8.4 Hz), 12.96 (1 H, s),
13.81 (1 H, bs) A-89 ##STR00112## H Cl H 7.31-7.37 (1 H, m),
7.41-7.66 (7 H, m), 8.03 (2 H, d, J = 8.5 Hz), 8.05 (1 H, s), 8.21
(2 H, d, J = 8.5 Hz), 13.00 (1 H, bs) A-90 ##STR00113## H Cl H 7.49
(1 H, s), 7.70 (1 H, d, J = 8.5 Hz), 8.02-8.10 (4 H, m), 8.19 (2 H,
d, J = 8.5 Hz), 12.97 (1 H, s), 13.82 (1 H, bs) A-91 ##STR00114## H
Cl H 7.48 (1 H, t, J = 7.9 Hz), 7.69 (1 H, dd, J = 7.9 Hz, 1.5 Hz),
7.74 (1 H, s), 7.81 (1 H, dd, J = 7.9 Hz, 1.8 Hz), 8.04 (2 H, d, J
= 8.5 Hz), 8.06 (1 H, s), 8.21 2 H, d, J = 8.5 Hz), 12.99 (1 H, s),
13.87 (1 H, bs) A-92 ##STR00115## H Cl H 7.47 (1 H, dd, J = 8.6 Hz,
2.7 Hz), 7.62 (1 H, d, J = 8.4 Hz), 7.88 (1 H, s), 8.02-8.05 (4 H,
m), 8.21 (2 H, d, J = 8.4 Hz), 12.93 (1 H, s), 13.88 (1 H, bs) A-93
##STR00116## H Cl H 0.86 (3 H, t, J = 6.9 Hz), 1.27-1.30 (6 H, m),
1.55- 1.62 (2 H, m), 2.68 (2 H, t, J = 7.5 Hz), 7.19-7.30 (2 H, m),
7.61 (1 H, d, J = 2.7 Hz), 7.94 (1 H, dt, J = 7.0 Hz, 2.0 Hz), 8.03
(2 H, d, J = 8.5 Hz), 8.05 (1 H, s), 8.21 (2 H, d, J = 8.5 Hz),
12.92 (1 H, s), 13.86 (1 H, bs) A-94 ##STR00117## H Cl H 13.70 (bs,
1 H), 12.93 (bs, 1 H), 8.21 (d, 2 H, J = 8.2 Hz), 8.06 (s, 1 H),
8.04 (d, 2 H, J = 8.2 Hz), 7.94 (dt, 1 H, J = 7.5, 2.0 Hz), 7.61
(d, 1 H, J = 2.7 Hz), 7.32 (m, 1 H), 7.25 (t, 1 H, J = 7.5 Hz),
2.90 (m, 1 H), 1.20-1.90 (m, 10 H) A-95 ##STR00118## H Cl H
0.85-0.89 (3 H, m), 1.27-1.35 (4 H, m), 1.53- 1.60 (2 H, m), 2.63
(2 H, t, J = 7.7 Hz), 7.11-7.17 (1 H, m), 7.34-7.41 (1 H, m), 7.51
(1 H, s), 8.03 (2 H, d, J = 8.5 Hz), 8.05 (1 H, s), 8.20 (2 H, d, J
= 8.5 Hz), 12.96 (1 H, s), 13.78 (1 H, bs)
TABLE-US-00009 TABLE 9 Compound No. R.sup.6 R.sup.1 R.sup.2 R.sup.5
.sup.1H-NMR (DMSO d-6) A-96 ##STR00119## H Cl H 0.96 (3 H, t, J =
7.4 Hz), 1.41-1.54 (2 H, m), 1.70- 1.78 (2 H, m), 4.08 (2 H, t, J =
6.4 Hz), 7.13-7.24 (2 H, m), 7.61-7.66 (2 H, m), 8.03 (2 H, d, J =
8.6 Hz), 8.05 (1 H, s), 8.21 (2 H, d, J = 8.6 Hz), 12.92 (1 H, s),
13.81 (1 H, bs) A-97 ##STR00120## H Cl H 1.23 (3 H, t, J = 7.5 Hz),
2.72 (2 H, q, J = 7.5 Hz), 7.21-7.33 (2 H, m), 7.61 (1 H, d, J =
2.5 Hz), 7.95 (1 H, dd, J = 7.5 Hz, 2.0 Hz), 8.04 (2 H, d, J = 8.5
Hz), 8.05 (1 H, s), 8.21 (2 H, d, J = 8.5 Hz), 12.92 (1 H, s),
13.85 (1 H, bs) A-98 ##STR00121## H Cl H 0.88 (6 H, d, J = 6.6 Hz),
1.19-1.26 (2 H, m), 1.53- 1.66 (3 H, m), 2.66 (2 H, t, J = 7.7 Hz),
7.20- 7.30 (2 H, m), 7.61 (1 H, d, J = 2.7 Hz), 7.95 (1 H, dd, J =
7.5 Hz, 2.2 Hz), 8.04 (2 H, d, J = 8.4 Hz), 8.05 (1 H, s), 8.21 (2
H, d, J = 8.4 Hz), 12.92 (1 H, s), 13.86 (1 H, bs) A-99
##STR00122## H Cl H 0.94 (3 H, t, J = 7.5 Hz), 1.63 (2 H, sext, J =
7.5 Hz), 2.67 (2 H, t, J = 2.67 Hz), 7.20-7.31 (2 H, m), 7.61 (1 H,
d, J = 2.7 Hz), 7.95 (1 H, td, J = 7.5 Hz, 24 Hz), 8.02-8.06 (3 H,
m), 8.22 (2 H, d, J = 8.4 Hz), 12.92 (1 H, s), 13.79 (1 H, bs)
A-100 ##STR00123## H Cl H 0.92 (3 H, t, J = 7.5 Hz), 1.35 (2 H,
sext, J = 7.5 Hz), 1.59 (2 H, quint, J = 7.5 Hz), 2.69 (2 H, t, J =
7.5 Hz), 7.19-7.30 (2 H, m), 7.61 (1 H, d, J = 2.7 Hz), 7.94 (1 H,
td, J = 8.2 Hz, 2.4 Hz), 7.99-8.06 (3 H, m), 8.21 (2 H, d, J = 8.4
Hz), 12.92 (1 H, s), 13.80 (1 H, bs) A-101 ##STR00124## H Cl H 0.98
(1 H, t, J = 7.5 Hz), 1.60 (2 H, sext, J = 7.5 Hz), 2.77-2.83 (2 H,
m), 7.59 (1 H, d, J = 8.4 Hz), 7.66 (1 H, d, J = 3.0 Hz), 7.91 (1
H, t, J = 8.4 Hz), 8.01-8.07 (3 H, m), 8.21 (2 H, d, J = 8.7 Hz),
12.94 (1 H, s), 13.80 (1 H, bs) A-102 ##STR00125## H Cl H 7.46 (1
H, t, J = 8.1 Hz), 7.54-7.60 (2 H, m), 7.70 (1 H, d, J = 2.7 Hz),
7.99-8.07 (4 H, m), 8.17 (1 H, dd, J = 8.2 Hz, 1.8 Hz), 8.21 (2 H,
d, J = 8.4 Hz), 8.66 (1 H, bs), 8.83 (1 H, bs), 12.97 (1 H, s)
A-103 ##STR00126## H Cl H 1.39 (3 H, t, J = 7.0 Hz), 4.15 (2 H, q,
J = 7.0 Hz), 7.13-7.25 (2 H, m), 7.62-7.67 (2 H, m), 8.04 (2 H, d,
J = 8.5 Hz), 8.06 (1 H, s), 8.22 (2 H, d, J = 8.5 Hz), 12.94 (1 H,
s), 13.86 (1 H, bs) A-104 ##STR00127## H Cl H 2.89-2.98 (4 H, m),
7.17-7.61 (7 H, m), 7.61 (1 H, d, J = 2.5 Hz), 7.95 (1 H, dt, J =
7.4 Hz, 2.2 Hz), 8.04 (2 H, d, J = 8.6 Hz), 8.05 (1 H, s), 8.21 (2
H, d, J = 8.6 Hz), 12.92 (1 H, s), 13.86 (1 H, bs) A-105
##STR00128## H Cl H 0.97 (9 H, s), 1.45-1.50 (2 H, m), 2.62-2.68 (2
H, m), 7.19-7.30 (2 H, m), 7.62 (1 H, d, J = 2.4 Hz), 7.94 (1 H,
dt, J = 7.5 Hz, 2.1 Hz), 8.04 (2 H, d, J = 8.5 Hz), 8.06 (1 H, s),
8.22 (2 H, d, J = 8.5 Hz), 12.92 (1 H, s), 13.85 (1 H, bs)
TABLE-US-00010 TABLE 10 Compound No. R.sup.6 R.sup.1 R.sup.2
R.sup.5 .sup.1H-NMR (DMSO d-6) A-106 ##STR00129## H Cl H 1.10 (3 H,
t, J = 6.9 Hz), 2.93 (2 H, t, J = 6.9 Hz), 3.46 (2 H, q, J = 6.9
Hz), 3.62 (2 H, t, J = 6.9 Hz), 7.24 (1 H, t, J = 7.5 Hz), 7.33 (1
H, td, J = 7.2 Hz, 1.8 Hz), 7.61 (1 H, d, J = 2.7 Hz), 7.97 (1 H,
td, J = 7.2 Hz, 1.8 Hz), 8.02-8.06 (3 H, m), 8.21 (2 H, d, J = 8.4
Hz), 12.93 (1 H, s), 13.89 (1 H, bs) A-107 ##STR00130## H Cl H 4.06
(2 H, s), 7.18-7.35 (7 H, m), 7.61 (1 H, d, J = 2.7 Hz), 7.98 (1 H,
td, J = 7.5 Hz, 2.1 Hz), 8.02- 8.05 (3 H, m), 8.21 (2 H, d, J = 8.7
Hz), 12.92 (1 H, s), 13.86 (1 H, bs)
TABLE-US-00011 TABLE 11 ##STR00131## Compound No. R.sup.6 R.sup.1
R.sup.2 R .sup.1H-NMR (DMSO d-6) B-2 ##STR00132## H H --NH.sub.2
6.77 (1 H, d, J = 15.9 Hz), 7.20 (1 H, br), 7.50 (1 H, d, J = 15.9
Hz), 7.60 (1 H, br), 7.72 (1 H, d, J = 8.7 Hz), 7.72-7.76 (2 H, m),
7.91 (1 H, s), 7.95 (1 H, dd, J = 1.8, 8.4 Hz), 8.14-8.18 (2 H, m),
8.22 (1 H, d, J = 1.8 Hz), 12.82 (1 H, br). B-3 ##STR00133## H H
--NHMe 2.73 (3 H, d, J = 4.8 Hz), 6.75 (1 H, d, J = 15.6 Hz), 7.50
(1 H, d, J = 15.6 Hz), 7.72 (1 H, d, J = 8.1 Hz), 7.72-7.75 (2 H,
m), 7.91 (1 H, s), 7.95 (1 H, dd, J = 2.1, 8.4 Hz), 8.09-8.18 (3 H,
m), 8.21 (1 H, d, J = 2.1 Hz), 12.81 (1 H, br). B-4 ##STR00134## H
Me --NHMe 2.06 (3 H, d, J = 1.5 Hz), 2.72 (3 H, t, J = 4.5 Hz),
7.27 (1 H, s), 7.53-7.58 (2 H, m), 7.72 (1 H, d, J = 8.7 Hz), 7.92
(1 H, s), 7.95 (1 H, dd, J = 1.8, 8.1 Hz), 8.07 (1 H, q, J = 4.2
Hz), 8.13-8.18 (2 H, m), 8.22 (1 H, d, J = 2.1 Hz), 12.81 (1 H, s).
B-5 ##STR00135## H Me --N(Me).sub.2 2.05 (3 H, d, J = 1.5 Hz), 3.32
(6 H, s), 6.57 (1 H, s), 7.54-7.58 (2 H, m), 7.72 (1 H, d, J = 8.4
Hz), 7.91 (1 H, s), 7.95 (1 H, dd, J = 1.8, 8.4 Hz), 8.13-8.18 (2
H, m), 8.22 (1 H, d, J 1.8 Hz), 12.79 (1 H, br). B-6 ##STR00136## H
Me --NHEt 1.10 (3 H, t, J = 7.2 Hz), 2.05 (3 H, d, J = 1.2 Hz),
3.17-3.26 (1 H, m), 7.25 (1 H, s), 7.54-7.58 (2 H, m), 7.72 (1 H,
d, J = 8.4 Hz), 7.91 (1 H, s), 7.95 (1 H, dd, J = 2.1, 8.1 Hz),
8.09 (1 H, t, J = 5.4 Hz), 8.13- 8.18 (2 H, m), 8.21 (1 H, d, J =
2.1 Hz), 12.80 (1 H, s). B-7 ##STR00137## H Me --NH(n-Pr) 0.89 (3
H, t, J = 7.2 Hz), 1.51 (2 H, sextet, d = 7.2 Hz), 2.06 (3 H, d, J
= 1.5 Hz), 3.11- 3.18 (2 H, m), 7.25 (1 H, s), 7.54-7.59 (2 H, m),
7.72 (1 H, d, J = 8.4 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J = 2.1,
8.4 Hz), 8.10 (1 H, t, J = 5.4 Hz), 8.14-8.19 (2 H, m), 8.22 (1 H,
d, J = 2.1 Hz), 12.82 (1 H, s). B-8 ##STR00138## H Me ##STR00139##
2.06 (3 H, d, J = 1.2 Hz), 3.53-3.58 (4 H, m), 3.60-3.64 (4 H, m),
6.60 (1 H, s), 7.54- 7.61 (2 H, m), 7.72 (1 H, d, J = 8.7 Hz), 7.91
(1 H, s), 7.95 (1 H, dd, J = 2.1, 8.7 Hz), 8.13-8.19 (2 H, m), 8.22
(1 H, d, J = 2.1 Hz), 12.80 (1 H, br).
TABLE-US-00012 TABLE 12 Compound No. R.sup.6 R.sup.1 R.sup.2 R
.sup.1H-NMR (DMSO d-6) B-9 ##STR00140## H Me --NHBn 2.10 (3 H, d, J
= 1.5 Hz), 4.41 (2 H, d, J = 6.0 Hz), 7.52-7.38 (6 H, m), 7.56-7.61
(2 H, m), 7.72 (1 H, d, J = 8.4 Hz), 7.92 (1 H, s), 7.95 (1 H, dd,
J = 2.1, 8.4 Hz), 8.14-8.20 (2 H, m), 8.22 (1 H, d, J = 2.4 Hz),
12.82 (1 H, br). B-10 ##STR00141## H Me ##STR00142## 2.22 (3 H, t,
J = 1.2 Hz), 7.34 (1 H, dt, J = 1.2, 8.1 Hz), 7.47 (1 H, dt, J =
1.2, 8.4 Hz), 7.65-7.71 (3 H, m), 7.73 (1 H, d, J = 8.4 Hz), 7.78
(1 H, d, J = 7.8 Hz), 7.94 (1 H, s), 7.96 (1 H, dd, J = 2.1, 8.4
Hz), 8.02 (1 H, d, J = 8.2 Hz), 8.19-8.24 (3 H, m), 12.63 (1 H,
br), 12.89 (1 H, br). B-11 ##STR00143## H Me ##STR00144## 2.18 (3
H, d, J = 1.5 Hz), 7.27 (1 H, d, J = 2.4 Hz), 7.56 (1 H, d, J = 3.3
Hz), 7.59 (1 H, br), 7.63-7.68 (2 H, m), 7.73 (1 H, d, J = 8.4 Hz),
7.93 (1 H, s), 7.96 (1 H, dd, J = 2.1, 8.4 Hz), 8.17-8.22 (2 H, m),
8.23 (1 H, d, J = 2.1 Hz), 12.36 (1 H, br), 12.87 (1 H, br). B-12
##STR00145## H Me ##STR00146## 2.18 (3 H, d, J = 1.2 Hz), 7.37-7.43
(2 H, m), 7.64-7.69 (2 H, m), 7.73 (1 H, d, J = 8.4 Hz), 7.94 (1 H,
s), 7.96 (1 H, dd, J = 1.8, 8.4 Hz), 8.15 (1 H, td, J = 1.5, 6.9
Hz), 8.18-8.24 (3 H, m), 8.31 (1 H, dd, J = 1.5, 4.5 Hz) 8.89 (1 H,
d, J = 2.4 Hz), 12.87 (1 H, br). B-13 ##STR00147## H Me
##STR00148## 2.11 (3 H, d, J = 1.2 Hz), 4.49 (2 H, d, J = 6.0 Hz),
7.36 (1 H, br), 7.52-7.62 (4 H, m), 7.69-7.74 (3 H, m), 7.92 (1 H,
s), 7.95 (1 H, dd, J = 2.1, 8.1 Hz), 8.15-8.20 (2 H, m), 8.22 (1 H,
d, J = 2.1 Hz), 8.79 (1 H, t, J = 6.3 Hz), 12.83 (1 H, br). B-14
##STR00149## H Me ##STR00150## 2.09 (3 H, d, J = 1.2 Hz), 4.38 (2
H, d, J = 5.7 Hz), 7.13-7.20 (2 H, m), 7.32-7.39 (3 H, m),
7.55-7.61 (2 H, m), 7.73 (1 H, d, J = 8.4 Hz), 7.92 (1 H, s), 7.95
(1 H, dd, J = 2.1, 8.4 Hz), 8.14-8.19 (2 H, m), 8.22 (1 H, d, J =
2.1 Hz), 8.71 (1 H, t, J = 6.0 Hz), 12.84 (1 H, br). B-15
##STR00151## H Me ##STR00152## 2.08 (3 H, d, J = 1.5 Hz), 4.55 (2
H, d, J = 5.7 Hz), 6.96-7.03 (2 H, m), 7.31 (1 H, br), 7.40 (1 H,
dd, J = 1.5, 5.4 Hz), 7.55- 7.60 (2 H, m), 7.73 (1 H, d, J = 8.4
Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J = 2.1, 8.4 Hz), 8.14-8.19 (2
H, m), 8.22 (1 H, d, J = 2.1 Hz), 8.80 (1 H, t, J = 6.0 Hz), 12.84
(1 H, br).
TABLE-US-00013 TABLE 13 Compound No. R.sup.6 R.sup.1 R.sup.2 R
.sup.1H-NMR (DMSO d-6) B-16 ##STR00153## H Me ##STR00154## 2.07 (3
H, d, J = 1.2 Hz), 4.39 (2 H, d, J = 5.7 Hz), 6.28 (1 H, d, J = 3.6
Hz), 6.41 (1 H, dd, J = 1.8, 3.3 Hz), 7.30 (1 H, br), 7.55-7.61 (3
H, m), 7.73 (1 H, d, J = 8.1 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J =
2.1, 8.4 Hz), 8.14-8.18 (2 H, m), 8.22 (1 H, d, J = 2.1 Hz), 8.63
(1 H, t, J = 6.0 Hz), 12.84 (1 H, br). B-17 ##STR00155## H Et
--NH.sub.2 1.07 (3 H, t, J = 7.2 Hz), 2.47 (2 H, q, J = 7.2 Hz),
7.20 (2 H, br), 7.48-7.53 (2 H, m), 7.65 (1 H, br), 7.73 (1 H, d, J
= 8.1 Hz), 7.93 (1 H, s), 7.95 (1 H, dd, J = 2.1, 8.4 Hz),
8.13-8.18 (2 H, m), 8.22 (1 H, d, J = 2.1 Hz), 12.83 (1 H, br).
B-18 ##STR00156## H Et --NHMe 1.05 (3 H, t, J = 7.5 Hz), 2.48 (2 H,
q, J = 7.5 Hz), 2.72 (2 H, d, J = 4.5 Hz), 7.11 (1 H, s), 7.48-7.53
(2 H, m), 7.73 (1 H, d, J = 8.4 Hz), 7.92 (1 H, s), 7.95 (1 H, dd,
J = 2.4, 8.1 Hz), 8.08-8.18 (3 H, m), 8.22 (1 H, d, J = 2.4 Hz),
12.82 (1 H, br). B-19 ##STR00157## H Et --NHEt 1.05 (3 H, t, J =
7.5 Hz), 1.10 (3 H, t, J = 7.2 Hz), 2.48 (2 H, q, J = 7.2 Hz),
3.16- 3.26 (2 H, m), 7.09 (1 H, s), 7.48-7.53 (2 H, m), 7.73 (1 H,
d, J = 8.4 Hz), 7.93 (1 H, s), 7.95 (1 H, dd, J = 2.1, 8.4 Hz),
8.14-8.20 (2 H, m), 8.22 (1 H, d, J = 2.1 Hz), 12.84 (1 H, br).
B-20 ##STR00158## H Et --NHBn 1.08 (3 H, t, J = 7.5 Hz), 2.52 (2 H,
q, J = 7.8 Hz), 4.41 (2 H, d, J = 6.3 Hz), 7.18 (1 H, s), 7.22-7.40
(5 H, m), 7.50-7.54 (2 H, m), 7.73 (1 H, d, J = 8.4 Hz), 7.93 (1 H,
s), 7.95 (1 H, dd, J = 1.8, 8.4 Hz), 8.14-8.18 (2 H, m), 8.22 (1 H,
d, J = 1.8 Hz), 8.75 (1 H, t, J = 6.0 Hz), 12.84 (1 H, br). B-21
##STR00159## Me Me --NH.sub.2 1.70 (3 H, d, J = 1.2 Hz), 2.04 (3 H,
d, J = 1.2 Hz), 7.21 (1 H, br), 7.35-7.41 (2 H, m), 7.52 (1 H, br),
7.73 (1 H, d, J = 8.4 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J = 2.1,
8.4 Hz), 8.13-8.18 (2 H, m), 8.22 (1 H, d, J = 1.8 Hz), 12.80 (1 H,
br). B-22 ##STR00160## Me Me --NHMe 1.69 (3 H, d, J = 1.2 Hz), 1.99
(3 H, d, J = 1.5 Hz), 2.69 (3 H, d, J = 4.5 Hz), 7.36- 7.41 (2 H,
m), 7.73 (1 H, d, J = 8.4 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J =
2.1, 8.4 Hz), 7.99 (1 H, q, J = 4.8 Hz), 8.13- 8.18 (2 H, m), 8.22
(1 H, d, J = 2.1 Hz), 12.80 (1 H, br).
TABLE-US-00014 TABLE 14 Compound No. R.sup.6 R.sup.1 R.sup.2 R
.sup.1H-NMR (DMSO d-6) B-23 ##STR00161## Me Me --NHEt 1.10 (3 H, t,
J = 7.2 Hz), 1.69 (3 H, d, J = 1.2 Hz), 2.00 (3 H, d, J = 1.5 Hz),
3.14- 3.23 (2 H, m), 7.36-7.41 (2 H, m), 7.73 (1 H, d, J = 8.4 Hz),
7.92 (1 H, s), 7.95 (1 H, dd, J = 2.1, 8.4 Hz), 8.06 (1 H, t, J =
5.4 Hz), 8.13-8.17 (2 H, m), 8.22 (1 H, d, J = 2.1 Hz), 12.80 (1 H,
br). B-24 ##STR00162## Me Me --NHBn 1.73 (3 H, d, J = 1.5 Hz), 2.00
(3 H, d, J = 1.5 Hz), 4.39 (2 H, d, J = 5.7 Hz), 7.22- 7.42 (7 H,
m), 7.73 (1 H, d, J = 8.4 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J =
1.8, 8.4 Hz), 8.12-8.18 (2 H, m), 8.22 (1 H, d, J = 1.8 Hz), 8.62
(1 H, t, J = 6.3 Hz), 12.80 (1 H, br). B-25 ##STR00163## H Me
--NH.sub.2 2.04 (3 H, d, J = 1.2 Hz), 7.20 (1 H, br), 7.32 (1 H,
br), 7.48-7.64 (4 H, m), 7.79- 7.86 (2 H, m), 7.94-8.02 (1 H, m),
8.14- 8.18 (2 H, m), 12.83 (1 H, br). B-26 ##STR00164## H Me --NHMe
2.06 (3 H, d, J = 1.2 Hz), 2.72 (3 H, d, J = 4.8 Hz), 7.26 (1 H,
s), 7.47-7.58 (3 H, m), 7.78-7.87 (2 H, m), 7.94-8.02 (1 H, m),
8.08 (1 H, q, J = 4.5 Hz) 8.13-8.18 (2 H, m), 12.82 (1 H, br). B-27
##STR00165## H Me --NH(CH.sub.2).sub.2--N(CH.sub.3).sub.2 2.05 (3
H, d, J = 1.2 Hz), 2.19 (6 H, s), 2.39 (2 H, t, J = 6.9 Hz), 3.28
(2 H, q, J = 6.9 Hz), 7.26 (1 H, br), 7.55 (2 H, d, J = 8.7 Hz),
7.72 (1 H, d, J = 8.1 Hz), 7.91 (1 H, s), 7.95 (1 H, dd, J = 2.1
Hz, 8.1 Hz), 8.01 (1 H, t, J = 5.7 Hz), 8.16 (2 H, d, J = 8.7 Hz),
8.22 (1 H, d, J = 2.1 Hz), 12.83 (1 H, br) B-28 ##STR00166## H Me
--NH(CH.sub.2).sub.2--COOH 2.05 (3 H, d, J = 1.5 Hz), 2.49 (3 H, t,
J = 7.5 Hz), 3.39 (2 H, q, J = 6.0 Hz), 7.26 (1 H, br), 7.56 (2 H,
d, J = 8.7 Hz), 7.73 (1 H, d, J = 8.4 Hz), 7.93 (1 H, s), 7.95 (1
H, dd, J = 1.8 Hz, 8.4 Hz), 8.16 (2 H, d, J = 8.7 Hz), 8.22 (1 H,
d, J = 1.8 Hz), 12.90 (2 H, br) B-29 ##STR00167## H Me
--NHN(CH.sub.3).sub.2 2.05 (3 H, s), 2.56 (6 H, s), 7.14 (1 H, s),
7.56 (2 H, d, J = 8.1 Hz), 7.73 (1 H, d, J = 8.1 Hz), 7.93 (1 H,
s), 7.95 (1 H, dd, J = 1.8 Hz, 8.1 Hz), 8.16 (2 H, d, J = 8.1 Hz),
8.22 (1 H, d, J = 1.8 Hz), 9.08 (1 H, s), 12.83 (1 H, br) B-30
##STR00168## H Me --NHPh 2.17 (3 H, d, J = 1.1 Hz), 7.07-7.11 (1 H,
m), 7.32-7.37 (3 H, m), 7.65 (2 H, d, J = 8.5 Hz), 7.73 (3 H, d, J
= 8.5 Hz), 7.93 (1 H, s), 7.96 (1 H, dd, J = 2.2 Hz, 8.5 Hz), 8.20
(2 H, d, J = 8.5 Hz), 8.22 (1 H, d, J = 2.2 Hz), 10.01 (1 H, s),
12.85 (1 H, s)
TABLE-US-00015 TABLE 15 Compound No. R.sup.6 R.sup.1 R.sup.2 R
.sup.1H-NMR (DMSO d-6) B-31 ##STR00169## H Me --NHCH.sub.2CF.sub.3
2.09 (3 H, d, J = 1.1 Hz), 4.02 (2 H, m), 7.34 (1 H, s), 7.60 (2 H,
d, J = 8.4 Hz), 7.73 (1 H, d, J = 8.5 Hz), 7.93 (1 H, s), 7.95 (1
H, dd, J = 2.2 Hz, 8.5 Hz), 8.18 (2 H, d, J = 8.4 Hz), 8.22 (1 H,
d, J = 2.2 Hz), 8.75 (1 H, t, J = 6.0 Hz), 12.85 (1 H, s) B-32
##STR00170## H Me --NH(CH.sub.2).sub.3--SCH.sub.3 1.76 (2 H, qn, J
= 6.9 Hz), 2.06 (6 H, s), 2.49-2.53 (2 H, m), 3.26 (2 H, q, J = 5.7
Hz), 7.26 (1 H, s), 7.57 (2 H, d, J = 8.4 Hz), 7.73 (1 H, d, J =
8.4 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J = 2.1 Hz, 8.4 Hz), 8.15 (1
H, t, J = 4.8 Hz), 8.16 (2 H, d, J = 8.4 Hz), 8.22 (1 H, d, J = 2.1
Hz), 12.83 (1 H, br) B-33 ##STR00171## H Me --NHCH(CH.sub.3)--Ph
1.46 (3 H, d, J = 7.2 Hz), 2.08 (2 H, d, J = 1.5 Hz), 5.08 (1 H,
qn, J = 7.2 Hz), 7.21- 7.41 (6 H, m), 7.69 (2 H, d, J = 8.4 Hz),
7.72 (1 H, d, J = 8.4 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J = 2.1
Hz, 8.4 Hz), 8.17 (2 H, d, J = 8.4 Hz), 8.22 (1 H, d, J = 2.1 Hz),
8.48 (1 H, d, J = 8.4 Hz), 12.83 (1 H, br) B-34 ##STR00172## H Me
--NHCH.sub.2Si--(CH.sub.3).sub.3 0.06 (9 H, s), 2.06 (3 H, d, J =
1.2 Hz), 2.72 (2 H, d, J = 5.4 Hz), 7.18 (1 H, s), 7.57 (2 H, d, J
= 8.4 Hz), 7.73 (1 H, d, J = 8.4 Hz), 7.93 (1 H, s), 7.95 (1 H, dd,
J = 2.1 Hz, 8.4 Hz), 7.99 (1 H, t, J = 5.4 Hz), 8.16 (2 H, d, J =
8.4 Hz), 8.22 (1 H, d, J = 2.1 Hz), 12.83 (1 H, s) B-35
##STR00173## H Me --NH(i-Bu) 0.87 (3 H, t, J = 7.1 Hz), 1.11 (3 H,
d, J = 6.6 Hz), 1.41-1.57 (2 H, m), 2.06 (3 H, d, J = 1.4 Hz), 3.83
(1 H, sexth, J = 6.6 Hz), 7.21 (1 H, s), 7.57 (2 H, d, J = 8.4 Hz),
7.72 (1 H, d, J = 8.4 Hz), 7.80 (1 H, d, J = 8.1 Hz), 7.92 (1 H,
s), 7.95 (1 H, dd, J = 2.1 Hz, 8.4 Hz), 8.17 (2 H, d, J = 8.4 Hz),
8.22 (1 H, d, J = 2.1 Hz), 12.82 (1 H, s) B-36 ##STR00174## H Me
--NH(c-Pr) 0.52-0.70 (4 H, m), 2.04 (3 H, d, J = 0.8 Hz), 2.74-2.80
(1 H, m), 7.56 (2 H, d, J = 8.1 Hz), 7.72 (1 H, d, J = 8.4 Hz),
7.92 (1 H, s), 7.95 (1 H, dd, J = 2.1 Hz, 8.4 Hz), 8.11 (1 H, d, J
= 4.2 Hz), 8.16 (2 H, d, J = 8.1 Hz), 8.22 (1 H, d, J = 2.1 Hz),
12.82 (1 H, s)
TABLE-US-00016 TABLE 16 Compound No. R.sup.6 R.sup.1 R.sup.2 R
.sup.1H-NMR (DMSO d-6) B-37 ##STR00175## H Me
--NH(CH.sub.2).sub.3O--CH.sub.3 0.87 (3 H, t, J = 7.1 Hz), 1.11 (3
H, d, J = 6.6 Hz), 1.41-1.57 (2 H, m), 2.06 (3 H, d, J = 1.4 Hz),
3.83 (1 H, sexth, J = 6.6 Hz), 7.25 (1 H, s), 7.57 (2 H, d, J = 8.7
Hz), 7.73 (1 H, d, J = 8.1 Hz), 7.95 (1 H, dd, J = 2.1 Hz, 8.1 Hz),
8.11 (1 H, t, J = 6.0 Hz), 8.16 (2 H, d, J = 8.7 Hz), 8.22 (1 H, d,
J = 2.1 Hz), 12.83 (1 H, s) B-38 ##STR00176## H Me --NH(c-Pen)
1.46-1.58 (4 H, m), 1.63-1.71 (2 H, m), 1.81-1.90 (2 H, m), 2.05 (3
H, s), 4.10- 4.15 (1 H, m), 7.20 (1 H, s), 7.57 (2 H, d, J = 8.4
Hz), 7.73 (1 H, d, J = 8.1 Hz), 7.92- 7.96 (3 H, m), 8.16 (2 H, d,
J = 8.4 Hz), 8.22 (1 H, d, J = 1.8 Hz), 12.82 (1 H, s) B-39
##STR00177## H Me --NH(t-Bu) 1.35 (9 H, s), 2.03 (3 H, d, J = 1.5
Hz), 7.13 (1 H, s), 7.56 (2 H, d, J = 8.4 Hz), 7.72 (1 H, d, J =
8.4 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J = 2.1 Hz, 8.4 Hz), 8.16 (2
H, d, J = 8.4 Hz), 8.22 (1 H, d, J = 2.1 Hz), 12.82 (1 H, s) B-40
##STR00178## H Me --NHpropargyl 2.06 (3 H, d, J = 1.2 Hz), 3.12 (1
H, t, J = 2.4 Hz), 3.98 (2 H, dd, J = 5.4 HZ, 2.4 Hz), 7.30 (1 H,
s), 7.58 (2 H, d, J = 8.4 Hz), 7.73 (1 H, d, J = 8.4 Hz), 7.20 (1
H, s), 7.95 (1 H, dd, J = 8.4 Hz, 2.1 Hz), 8.16 (2 H, d, J = 8.4
Hz), 8.22 (1 H, d, J = 2.1 Hz), 8.57 (1 H, t, J = 5.4 Hz), 12.83 (1
H, s) B-41 ##STR00179## H Me --NHallyl 2.08 (3 H, d, J = 1.2 Hz),
3.83 (2 H, t, J = 5.7 Hz), 5.07-5.21 (2 H, m), 5.94-5.81 (1 H, m),
7.29 (1 H, s), 7.58 (2 H, d, J = 8.4 Hz), 7.73 (1 H, d, J = 8.7
Hz), 7.92 (1 H, s), 7.94 (1 H, dd, J = 8.4 Hz, 1.8 Hz), 8.17 (2 H,
d, J = 8.4 Hz), 8.22 (1 H, d, J = 1.8 Hz), 8.31 (1 H, t, J = 5.7
Hz), 12.83 (1 H, s) B-42 ##STR00180## H Me
--NH(CH.sub.2).sub.2O--CH.sub.3 2.06 (3 H, d, J = 1.2 Hz), 3.28 (3
H, s), 3.37-3.46 (4 H, m), 7.27 (1 H, s), 7.57 (2 H, d, J = 8.7
Hz), 7.72 (1 H, d, J = 8.4 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J =
8.4 Hz, 2.1 Hz), 8.15 (1 H, s), 8.17 (2 H, d, J = 8.7 Hz), 8.22 (1
H, d, J = 2.1 Hz), 12.83 (1 H, s) B-43 ##STR00181## H Me --NHNHAc
1.91 (3 H, s), 2.08 (3 H, d, J = 1.5 Hz), 7.32 (1 H, s), 7.59 (2 H,
d, J = 8.4 Hz), 7.73 (1 H, d, J = 8.4 Hz), 7.95 (1 H, dd, J = 8.4
Hz, 1.8 Hz), 8.18 (2 H, d, J = 8.4 Hz), 8.22 (1 H, d, J = 1.8 Hz),
9.81 (1 H, s), 9.95 (1 H, s), 12.85 (1 H, s)
TABLE-US-00017 TABLE 16 Compound No. R.sup.6 R.sup.1 R.sup.2 R
.sup.1H-NMR (DMSO d-6) B-44 ##STR00182## H Me --NHNHPh 2.13 (3 H,
d, J = 1.2 Hz), 6.73 (1 H, t, J = 7.5 Hz), 6.80 (2 H, d, J = 7.8
Hz), 7.17 (2 H, t, J = 8.1 Hz), 7.38 (1 H, s), 7.63 (2 H, d, J =
8.4 Hz), 7.73 (1 H, d, J = 8.1 Hz), 7.82 (1 H, d, J = 2.7 Hz), 7.93
(1 H, s), 7.96 (1 H, dd, J = 8.1 Hz, 1.8 Hz), 8.19 (2 H, d, J = 8.4
Hz), 8.23 (1 H, d, J = 1.8 Hz), 10.04 (1 H, d, J = 2.7 Hz), 12.86
(1 H, s) B-45 ##STR00183## H Me --N(CH.sub.3)NH.sub.2 2.10 (3 H,
s), 3.11 (3 H, s), 4.84 (2 H, bs), 6.59 (1 H, s), 7.53 (2 H, d, J =
8.1 Hz), 7.71 (1 H, d, J = 8.1 Hz), 7.85 (1 H, s), 7.94 (1 H, dd, J
= 8.1 Hz, 1.8 Hz), 8.15 (2 H, d, J = 8.1 Hz), 8.21 (1 H, d, J = 1.8
Hz), 12.63 (1 H, br) B-46 ##STR00184## H Me --NHOCH.sub.3 2.03 (3
H, d, J = 1.5 Hz), 3.68 (3 H, s), 7.20 (1 H, s), 7.57 (2 H, d, J =
8.4 Hz), 7.72 (1 H, d, J = 8.1 Hz), 7.95 (1 H, dd, J = 8.1 Hz, 2.1
Hz), 8.16 (2 H, d, J = 8.4 Hz), 8.22 (1 H, d, J = 2.1 Hz), 11.43 (1
H, s), 12.84 (1 H, s)
TABLE-US-00018 TABLE 18 ##STR00185## Com- pound No. R.sup.10
R.sup.1 R.sup.2 R.sup.5 .sup.1H-NMR (DMSO d-6) C-1 ##STR00186## H
Me Me 2.08 (3 h, d, J = 1.2 Hz), 3.64 (3 H, s), 6.87 (1 H, s), 7.38
(2 H, d, J = 8.7 Hz), 7.72 (1 H, d, J = 8.7 Hz), 7.91 (1 H, s),
7.95 (1 H, dd, J = 8.7 Hz, 2.1 Hz), 8.08 (2 H, d, J = 8.4 Hz), 8.21
(1 H, d, J = 2.1 Hz), 12.79 (1 H, s) C-2 ##STR00187## H Me H 2.06
(3 H, d, J = 1.2 Hz), 6.69 (1 H, s), 7.46 (2 H, d, J = 9.0 Hz),
7.72 (1 H, d, J = 8.7 Hz), 7.92 (1 H, s), 7.94 (1 H, dd, J = 8.4
Hz, 1.8 Hz), 8.08 (2 H, d, J = 8.7 Hz), 8.22 (1 H, d, J = 2.1 Hz),
12.77 (1 H, s), 12.91 (1 H, s) C-3 ##STR00188## H Br Me 3.76 (3 H,
s), 7.48 (2 H, d, J = 8.7 Hz), 7.69 (1 H, s), 7.72 (1 H, d, J = 8.4
Hz), 7.93 (1 H, s), 7.95 (1 H, dd, J = 8.4 Hz, 2.1 Hz), 8.11 (2 H,
d, J = 8.4 Hz), 8.21 (1 H, d, J = 2.1 Hz), 12.86 (1 H, s) C-4
##STR00189## H Br H 7.47 (1 H, s), 7.54 (2 H, d, J = 8.7 Hz), 7.92
(1 H, s), 7.95 (1 H, dd, J = 8.4 Hz, 2.1 Hz), 8.11 (2 H, d, J = 8.4
Hz), 8.21 (1 H, d, J = 1.8 Hz), 12.83 (1 H, s) C-5 ##STR00190## H F
H 7.19 (1 H, d, J = 23.1 Hz), 7.68 (2 H, d, J = 8.4 Hz), 7.73 (1 H,
d, J = 8.1 Hz), 7.93 (1 H, s), 7.95 (1 H, dd, J = 8.1 Hz, 2.1 Hz),
8.11 (2 H, d, J = 8.1 Hz), 8.22 (1 H, d, J = 1.8 Hz), 12.84 (1 H,
s)
TABLE-US-00019 TABLE 19 ##STR00191## Com- pound No. R.sup.10
R.sup.1 R.sup.2 Het .sup.1H-NMR (DMSO d-6) D-1 ##STR00192## H Me
##STR00193## 2.35 (3 H, d, J = 0.9 Hz), 7.12 (2 H, bs), 7.32 (1 H,
s), 7.58 (2 H, d, J = 8.1 Hz), 7.72 (1 H, d, J = 7.8 Hz), 7.92 (1
H, s), 7.95 (1 H, dd, J = 8.4 Hz, 2.1 Hz), 8.17 (2 H, d, J = 8.4
Hz), 8.22 (1 H, d, J = 1.8 Hz), 12.31 (1 H, s), 12.79 (1 H, s)
TABLE-US-00020 TABLE 20 ##STR00194## Com- pound No. R.sup.10
R.sup.1 R.sup.2 R .sup.1H-NMR (DMSO d-6) E-1 ##STR00195## H Me anti
OH 12.80 (bs, 1 H), 11.20 (s, 1 H), 8.21 (s, 1 H), 8.15 (d, 2 H, J
= 8.3 Hz), 7.95 (m, 1 H), 7.93 (s, 1 H), 7.90 (s, 1 H), 7.72 (d, 1
H, J = 8.5 Hz), 7.57 (d, 2 H, J = 8.3 Hz), 6.83 (s, 1 H), 2.10 (s,
3 H) E-2 ##STR00196## H Me syn OH 10.60 (bs, 1 H), 8.12 (d, 1 H, J
= 1.9 Hz), 8.03 (d, 2 H, J = 8.5 Hz), 7.87 (dd, 1 H, J = 8.5, 1.9
Hz), 7.58 (d, 1 H, J = 8.5 Hz), 7.26 (s, 1 H), 7.16 (d, 2 H, J =
8.2 Hz), 6.56 (d, 1 H, J = 7.1 Hz), 3.20 (m, 1 H), 2.51-2.80 (m, 2
H), 0.98 (d, 3 H, J = 6.9 Hz)
TABLE-US-00021 TABLE 21 ##STR00197## Com- pound No. R.sup.10
R.sup.1 R.sup.2 R .sup.1H-NMR (DMSO d-6) F-1 ##STR00198## H Me
--N(Me).sub.2 (CDCl3) 2.24 (d, 3 H, J = 1.5 Hz), 2.92 (s, 6 H),
7.24 (s, 1 H), 7.47 (d, 1 H, J = 8.2 Hz), 7.52 (s, 1 H), 7.53 (d, 2
H, J = 8.5 Hz), 7.64 (dd, 1 H, J = 8.2, 1.8 Hz), 7.93 (d, 1 H, J =
1.8 Hz), 8.00 (d, 2 H, J = 8.5 Hz), 9.85 (brs, 1 H). F-2
##STR00199## H Me --NH(t-Bu) (CDCl3) 1.38 (s, 9 H), 2.28 (d, 3 H, J
= 1.4 Hz), 4.19 (s, 1 H), 7.24 (s, 1 H), 7.49 (d, 1 H, J = 8.2 Hz),
7.53 (d, 2 H, J = 8.5 Hz), 7.62 (brs, 1 H), 7.66 (dd, 1 H, J = 8.2,
1.9 Hz), 7.96 (d, 1 H, J = 1.9 Hz), 8.03 (d, 2 H, J = 8.5 Hz), 9.80
(brs, 1 H). F-3 ##STR00200## H Me --NH.sub.2 2.25 (d, 3 H, J = 1.2
Hz), 7.17 (s, 2 H), 7.42 (brs, 1 H), 7.64 (d, 2 H, J = 8.2 Hz),
7.73 (d, 2 H, J = 8.2 Hz), 7.92 (s, 1 H), 7.95 (dd, 1 H, J = 8.2,
2.1 Hz), 8.18 (d, 2 H, J = 8.2 Hz), 8.22 (d, 1 H, J = 2.1 Hz),
12.90 (brs, 1 H).
TABLE-US-00022 TABLE 22 ##STR00201## Com- pound No. R.sup.10
R.sup.1 R.sup.2 R.sup.5 .sup.1H-NMR (DMSO d-6) G-1 ##STR00202## H H
Me 2.67 (2 H, t, J = 7.7 Hz), 3.02 (2 H, t, J = 7.7 Hz), 3.69 (3 H,
s), 7.20 (1 H, s), 7.26 (1 H, s), 7.29 (2 H, d, J = 8.2 Hz), 7.41
(1 H, d, J = 8.5 Hz), 7.58 (1 H, dd, J = 8.5 Hz, 2.2 Hz), 7.82 (2
H, d, J = 8.2 Hz), 7.86 (1 H, d, J = 2.2 Hz), 10.15 (1 H, bs)
(CDCl3) G-2 ##STR00203## H H H 2.61 (2 H, t, J = 7.3 Hz), 2.92 (2
H, t, J = 7.3 Hz), 7.42 (2 H, d, J = 8.5 Hz), 7.41 (1 H, d, J = 8.5
Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J = 8.5 Hz, 2.1 Hz), 8.05 (2 H,
d, J = 8.5 Hz), 8.22 (1 H, d, J = 2.1 Hz), 12.27 (1 H, bs), 14.73
(1 H, bs) G-3 ##STR00204## H Me H 1.07 (3 H, d, J = 6.6 Hz),
2.68-2.77 (2 H, m), 2.94-3.03 (1 H, m), 7.39 (2 H, d, J = 8.5 Hz),
7.72 (1 H, d, J = 8.5 Hz), 7.95 (1 H, dd, J = 8.5 Hz, 2.2 Hz), 8.06
(2 H, d, J = 8.5 Hz), 8.21 (1 H, d, J = 2.2 Hz), 12.19 (1 H, bs),
12.69 (1 H, bs) G-4 ##STR00205## H Cl H 3.19 (1 H, dd, J = 14.3 Hz,
8.2 Hz), 3.42 (1 H, dd, J = 14.3 Hz, 6.3 Hz), 4.83 (1 H, dd, J =
8.2 Hz, 6.3 Hz), 7.48 (2 H, d, J = 8.2 Hz), 7.72 (1 H, d, J = 8.5
Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J = 8.5 Hz, 1.9 Hz), 8.08 (2 H,
d, J = 8.2 Hz), 8.22 (1 H, d, J = 1.9 Hz), 12.77 (1 H, bs), 13.46
(1 H, bs) G-5 ##STR00206## H Cl Me 3.21 (1 H, dd, J = 14.3 Hz, 8.0
Hz), 3.41 (1 H, dd, J = 14.3 Hz, 6.6 Hz), 3.77 (3 H, s), 4.46 (1 H,
dd, J = 8.0 Hz, 6.6 Hz), 7.20 (1 H, s), 7.26 (2 H, d, J = 8.5 Hz),
7.35 (1 H, d, J = 8.5 Hz), 7.52 (1 H, dd, J = 8.5 Hz, 2.2 Hz),
7.78-7.81 (3 H, m), 10.71 (1 H, bs) (CDCl3) G-6 ##STR00207## H F H
3.11-3.39 (2 H, m), 5.23-5.44 (1 H, m), 7.46 (2 H, d, J = 8.2 Hz),
7.72 (1 H, d, J = 8.2 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J = 8.2
Hz, 2.1 Hz), 8.09 (2 H, d, J = 8.2 Hz), 8.22 (1 H, d, J = 2.1 Hz),
13.45 (1 H, bs)
TABLE-US-00023 TABLE 23 Com- pound No. R.sup.10 R.sup.1 R.sup.2
R.sup.5 .sup.1H-NMR (DMSO d-6) G-7 ##STR00208## H F Et 1.20 (3 H,
t, J = 7.1 Hz), 3.14-3.39 (2 H, m), 4.17 (2 H, q, J = 7.1 Hz),
5.36-5.56 (1 H, m), 7.45 (2 H, d, J = 8.5 Hz), 7.72 (1 H, d, J =
8.2 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J = 8.2 Hz, 1.9 Hz), 8.08 (2
H, d, J = 8.2 Hz), 8.22 (1 H, d, J = 1.9 Hz), 12.78 (1 H, bs) G-8
##STR00209## Me Cl H 1.39 (3 H, d, J = 7.1 Hz), 3.41-3.49 (1 H, m),
4.78 (1 H, d, J = 8.5 Hz), 7.52 (2 H, d, J = 8.5 Hz), 7.72 (1 H, d,
J = 8.5 Hz), 7.92 (1 H, s), 7.95 (1 H, dd, J = 8.5 Hz, 1.9 Hz),
8.09 (2 H, d, J = 8.2 Hz), 8.22 (1 H, d, J = 1.9 Hz), 12.76 (1 H,
bs)
TABLE-US-00024 TABLE 24 ##STR00210## Com- pound No. R.sup.10 Z
R.sup.1 R.sup.2 R.sup.5 .sup.1H-NMR (DMSO d-6) H-1 ##STR00211##
##STR00212## H H Et (CDCl.sub.3) 10.10 (bs, 1 H), 8.06 (s, 1 H),
7.91 (d, 1 H, J = 8.0 Hz), 7.89 (d, 1 H, J = 2.0 Hz), 7.72 (d, 1 H,
J = 8.0 Hz), 7.69 (d, 1 H, J = 16.0 Hz), 7.61 (d, 1 H, J = 8.5, 2.0
Hz), 7.53 (t, 1 H, J = 8.0 Hz), 7.43 (d, 1 H, J = 8.5 Hz), 7.23 (s,
1 H), 6.51 (d, 1 H, J = 16.0 Hz), 4.30 (q, 2 H, J = 7.0 Hz),1.35
(t, 3 H, J = 7.0 Hz) H-2 ##STR00213## ##STR00214## H H H 12.90 (s,
1 H), 12.50 (s, 1 H), 8.57 (s, 1 H), 8.23 (d, 1 H, J = 2.0 Hz),
8.10 (d, 1 H, J = 8.0 Hz), 7.96 (dd, 1 H, J = 8.5, 2.0 Hz), 7.94
(s, 1 H), 7.92 (d, 1 H, J = 8.0 Hz), 7.73 (d, 1 H, J = 8.0 Hz),
7.68 (d, 1 H, J = 16.0 Hz), 7.62 (t, 1 H, J = 8.0 Hz), 6.76 (d, 1
H, J = 16.0 Hz) H-3 ##STR00215## ##STR00216## H H Me 2.22 (3 H, s),
2.42 (3 H, s), 3.85 (3 H, s), 6.37 (1 H, d, J = 15.9 Hz), 7.10 (1
H, s), 7.18 (1 H, s), 7.25 (1 H, s), 7.31 (1 H, d, J = 8.5 Hz),
7.40 (1 H, dd, J = 8.5 Hz, 1.9 Hz), 7.63 (1 H, d, J = 1.9 Hz), 7.82
(1 H, d, J = 15.9 Hz), 11.30 (1 H, bs) (CDCl3) H-4 ##STR00217##
##STR00218## H H H 2.41 (6 H, s), 6.55 (1 H, d, J = 15.9 Hz), 7.53
(1 H, s), 7.69 (1 H, s), 7.72 (1 H, d, J = 8.4 Hz), 7.79 (1 H, d, J
= 15.9 Hz), 7.73 (1 H, dd, J = 8.4 Hz, 1.9 Hz), 8.18 (1 H, d, J =
1.9 Hz), 12.70 (1 H, s) H-5 ##STR00219## ##STR00220## H Cl Et 1.42
(3 H, t, J = 6.9 Hz), 2.16 (3 H, s), 2.43 (3 H, s), 4.39 (q, 2 H, J
= 6.9 Hz), 7.17 (1 H, s), 7.19 (1 H, s), 7.26 (1 H, s), 7.34 (1 H,
d, J = 8.7 Hz), 7.45 (1 H, dd, J = 8.7 Hz, 2.1 Hz), 7.47 (1 H, s),
7.69 (1 H, d, J = 2.1 Hz), 7.91 (1 H, s), 11.09 (1 H, s) (CDCl3)
H-6 ##STR00221## ##STR00222## H Cl H 2.31 (3 H, s), 2.42 (3 H, s),
7.56 (1 H, s), 7.57 (1 H, s), 7.72 (1 H, d, J = 8.5 Hz), 7.91-7.94
(2 H, m), 8.04 (1 H, s), 8.18 (1 H, d, J = 1.9 Hz), 12.71 (1 H,
s)
TABLE-US-00025 TABLE 25 ##STR00223## Com- pound No. R.sup.10 Z
R.sup.1 R.sup.2 R.sup.5 .sup.1H-NMR (DMSO d-6) H-7 ##STR00224##
##STR00225## H Cl H 7.73 (d, 1 H, J = 8.6 Hz), 7.95 (dd, 1 H, J =
8.6, 1.8 Hz), 7.97 (s, 1 H), 8.03 (s, 1 H), 8.04-8.10 (m, 2 H),
8.17 (t, 1 H, J = 7.7 Hz), 8.02 (d, 1 H, J = 1.8 Hz), 13.01 (s, 1
H), 14.09 (s, 1 H) H-8 ##STR00226## ##STR00227## H Cl H 7.55 (t, 1
H, J = 7.7 Hz), 7.78 (m, 1 H), 7.79 (d, 1 H, J = 2.7 Hz), 7.86 (d,
1 H, J = 4.5 Hz), 8.32 (s, 1 H), 8.35 (d, 1 H, J = 4.5 Hz), 8.39
(t, 1 H, J = 7.7 Hz), 13.18 (s, 1 H), 13.87 (br, 1 H)
TABLE-US-00026 TABLE 26 ##STR00228## Com- pound No. R.sup.10 Y
R.sup.1 R.sup.2 R.sup.5 .sup.1H-NMR (DMSO d-6) I-1 ##STR00229##
--NHCH.sub.2-- H Me Et (CDCl.sub.3) 7.91 (d, 1 H, J = 1.9 Hz), 7.67
(d, 1 H, J = 1.3 Hz), 7.62 (dd, 1 H, J = 8.3, 1.9 Hz), 7.43 (d, 1
H, J = 8.3 Hz), 7.41 (s, 4 H), 6.73 (s, 1 H), 5.57 (m, 1 H), 4.57
(d, 2 H, J = 5.8 Hz), 4.27 (q, 2 H, J = 7.1 Hz), 2.11 (d, 3 H, J =
1.3 Hz), 1.35 (t, 3 H, J = 7.1 Hz) I-2 ##STR00230## --NHCH.sub.2--
H Me H 12.50 (bs, 1 H), 8.29 (t, 1 H, J = 5.5 Hz), 8.03 (d, 1 H, J
= 2.0 Hz), 7.80 (dd, 1 H, J = 8.5, 2.0 Hz), 7.61 (d, 1 H, J = 8.5
Hz, 7.57 (s, 1 H), 7.45 (s, 4 H), 7.30 (s, 1 H), 4.54 (d, 2 H, J =
5.5 Hz), 2.02 (d, 3 H, J = 0.5 Hz) I-3 ##STR00231##
--NHCOCH.sub.2-- H Me Et (CDCl.sub.3) 8.82 (bs, 1 H), 7.88 (d, 1 H,
J = 2.0 Hz), 7.68 (s, 1 H), 7.58 (dd, 1 H, J = 8.0, 2.0 Hz), 7.45
(d, 2 H, J = 8.2 Hz), 7.44 (d, 1 H, J = 8.5 Hz), 7.35 (d, 1 H, J =
8.2 Hz), 7.15 (s, 1 H), 4.29 (q, 2 H, J = 7.0 Hz), 3.85 (s, 2 H),
2.14 (d, 3 H, J = 1.4 Hz), 1.36 (t, 3 H, J = 7.0 Hz) I-4
##STR00232## --NHCOCH.sub.3-- H Me H 12.60 (bs, 1 H), 12.50 (bs, 1
H), 8.14 (d, 1 H, J = 2.0 Hz), 7.88 (dd, 1 H, J = 8.5, 2.0 Hz),
7.84 (s, 1 H), 7.70 (d, 1 H, J = 8.5 Hz), 7.85 (s, 1 H), 7.45 (d, 2
H, J = 8.5 Hz), 7.40 (d, 2 H, J = 8.5 Hz), 3.84 (s, 2 H), 2.03 (d,
3 H, J = 1.5 Hz) I-5 ##STR00233## --NHSO.sub.2-- H Me Et (CDCl3)
1.35 (t, 3 H, J = 7.2 Hz), 2.06 (d, 3 H, J = 1.5 Hz), 4.27 (q, 2 H,
J = 7.2 Hz), 6.64 (s, 1 H), 7.35 (dd, 1 H, J = 8.2, 2.1 Hz), 7.42
(d, 2 H, J = 8.2 Hz), 7.44 (d, 1 H, J = 8.2 Hz), 7.58 (d, 1 H, J =
2.1 Hz), 7.62 (s, 1 H), 7.98 (d, 2 H, J = 8.2 Hz). I-6 ##STR00234##
--NHSO.sub.2-- H Me H (CDCl3 + CD3OD) 2.09 (d, 3 H, J = 1.5 Hz),
6.66 (s, 1 H), 7.40 (dd, 1 H, J = 8.2, 2.4 Hz), 7.49 (d, 2 H, J =
8.5 Hz), 7.52 (d, 1 H, J = 8.2 Hz), 7.66 (d, 1 H, J = 2.4 Hz), 7.69
(s, 1 H), 7.97 (d, 2 H, J = 8.5 Hz).
Example 3
The Preparation of Compound (A-15)
##STR00235##
[0135] To a suspension of
methoxy-methoxycarbonylmethyl-triphenylphosphonium chloride (152
mg) and 2-(4-formylbenzoylamino)-4-(3,4-dichlorophenyl)thiazole (57
mg) in methylene chloride (3 ml) was added triethylamine (38 mg),
and the reaction mixture was stirred at room temperature for
overnight. The mixture was concentrated, purified by silica gel
column chromatography to obtain compound (A-15) 30 mg.
[0136] Melting point: 203.about.205.degree. C.
[0137] .sup.1H-NMR (CDCl.sub.3) .delta. ppm: 3.85 (s, 3H), 3.89 (s,
3H), 6.96 (s, 1H), 7.22 (s, 1H), 7.46 (dd, 1H, J= 8.2, 1.9 Hz),
7.63 (d, 1H, J= 8.2 Hz) 7.86 (d, 2H, J= 8.6 Hz), 7.92 (d, 1H, J=
1.9 Hz), 7.94 (d, 2H, J= 8.6 Hz), 9.82 (brs, 1H).
Example 4
The Preparation of Compound (J-3)
[0138] A solution of (E)-3-(4-iodophenyl)-2-methylacrylic acid
ethyl ester (200 mg), dichlorobis(triphenylphosphine)palladium (II)
(22 mg), 2-amino-4-(4'-chlorophenyl)-1H-imidazole (277 mg), and
triethylamine (0.27 ml) in DMF (7 ml) was stirred under carbon
monooxide atmosphere at 90.degree. C. for 15 min. The reaction
mixture was cooled, poured into water. The precipitated crystals
were filtered, recrystallized with DMF to obtain compound (J-3) 117
mg as light yellow crystals.
Example 5
The Preparation of Compound (J-16)
[0139] To a solution of ethyl ester of compound (A-53) (300 mg) in
acetonitrile/tetrahydrofuran (1/1, 80 ml), was added
1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane
bistetrafluoroborate (50% on alumina 1.24 g), was stirred at
80.degree. C. for 30 min. Alumina was filtered off, the filtrate
was concentrated under reduced pressure, and added chloroform. The
insoluble materials was filtered off again, and the filtrate was
concentrated. The residue was purified by preparative TLC plate to
obtain fluoro derivative 20 mg as yellow crystals. The obtained
ester derivative was solvolized in a manner similar to preparing
compound (A-2) to obtain compound (J-16).
[0140] Compound (J-1) to (J-2), (J-4) to (J-15), and (J-17) were
synthesized in a manner similar to Example 4 and 5. Their physical
data of compound were shown in Tables 27 to 28.
TABLE-US-00027 TABLE 27 ##STR00236## Com- pound No. X R.sup.1
R.sup.2 R.sup.5 .sup.1H-NMR (DMSO d-6) J-1 ##STR00237## H Cl Et
1.33 (3 H, t, J = 7.2 Hz), 4.32 (2 H, q, J = 7.2 Hz), 6.13 (1 H,
s), 7.24 (1 H, t, J = 7.5 Hz), 7.46 (2 H, t, J = 8.1 Hz), 7.76 (2
H, d, J = 7.8 Hz), 7.98-8.12 (5 H, m), 11.02 (1 H, s), 11.89 (1 H,
s) J-2 ##STR00238## H Cl H 6.13 (1 H, s), 7.24 (1 H, t, J = 7.2
Hz), 7.46 (2 H, t, J = 8.1 Hz), 7.75 (2 H, d, J = 8.4 Hz),
7.96-8.12 (5 H, m), 11.01 (1 H, s), 11.86 (1 H, s), 13.80 (1 H, bs)
J-3 ##STR00239## H Me Et 12.07 (bs, 1 H), 11.74 (bs, 1 H), 8.13 (d,
2 H, J = 8.5 Hz), 7.79 (d, 2 H, J = 8.5 Hz), 7.67 (s, 1 H), 7.63
(d, 2 H, J = 8.5 Hz), 7.44 (s, 1 H), 7.40 (d, 2 H, J = 8.5 Hz),
4.22 (q, 2 H, J = 7.0 Hz), 2.09 (d, 3 H, J = 1.2 Hz), 1.29 (t, 3 H,
J = 7.0 Hz) J-4 ##STR00240## H Me H 12.10 (bs, 3 H), 8.12 (d, 2 H,
J = 8.5 Hz), 7.80 (d, 2 H, J = 8.5 Hz), 7.65 (s, 1 H), 7.62 (d, 2
H, J = 8.5 Hz), 7.45 (s, 1 H), 7.40 (d, 2 H, J = 8.5 Hz), 2.07 (d,
3 H, J = 1.5 Hz) J-5 ##STR00241## H Me Et 14.00 (bs, 1 H), 12.20
(bs, 1 H), 8.10-8.20 (m, 3 H), 7.95 (dd, 1 H, J = 8.2, 1.9 Hz),
7.77 (d, 1 H, J = 8.2 Hz), 7.60-7.70 (m, 3 H), 4.23 (q, 2 H, J =
7.0 Hz), 2.10 (s, 3 H), 1.29 (t, 3 H, J = 7.0 Hz) J-6 ##STR00242##
H Me H 13.95 (bs, 1 H), 12.69 (bs, 1 H), 12.22 (bs, 1 H), 8.10-8.18
(m, 3 H), 7.95 (dd, 1 H, J = 8.2, 2.0 Hz), 7.77 (d, 1 H, J = 8.2
Hz), 7.61- 7.68 (m, 3 H), 2.07 (d, 3 H, J = 1.2 Hz) J-7
##STR00243## H Me Et 13.24 (bs, 1 H), 8.20 (d, 2 H, J = 8.2 Hz),
7.96-8.04 (m, 2 H), 7.64-7.70 (m, 3 H), 7.52- 7.60 (m, 3 H), 4.23
(q, 2 H, J = 7.0 Hz), 2.10 (d, 3 H, J = 1.4 Hz), 1.29 (t, 3 H, J =
7.0 Hz) J-8 ##STR00244## H Me Et 13.72 (bs, 1 H), 8.20-8.30 (m, 4
H), 7.66- 7.74 (m, 3 H), 7.50-7.58 (m, 3 H), 4.23 (q, 2 H, J = 7.0
Hz), 2.10 (s, 3 H), 1.30 (t, 3 H, J = 7.0 Hz) J-9 ##STR00245## H Me
Et 10.50 (s, 1 H), 8.06 (d, 2 H, J = 8.2 Hz), 7.79 (d, 2 H, J = 7.1
Hz), 7.62-7.70 (m, 3 H), 7.41 (t, 2 H, J = 7.5 Hz), 7.30 (t, 1 H, J
= 7.5 Hz), 6.74 (s, 1 H), 4.23 (q, 2 H, J = 7.1 Hz), 3.77 (s, 3 H),
2.09 (d, 3 H, J = 1.1 Hz), 1.29 (t, 3 H, J = 7.1 Hz)
TABLE-US-00028 TABLE 28 Com- pound No. X R.sup.1 R.sup.2 R.sup.5
.sup.1H-NMR (DMSO d-6) J-10 ##STR00246## H Me H 12.64 (bs, 1 H),
7.99 (d, 2 H, J = 8.2 Hz), 7.72 (d, 2 H, J = 8.5 Hz), 7.66 (s, 1
H), 7.28- 7.38 (m, 5 H), 6.95 (s, .1 H), 2.07 (d, 3 H, J = 1.2 Hz)
J-11 ##STR00247## H Cl H 2.31 (3 H, d, J = 1.9 Hz), 7.18-7.24 (1 H,
m), 7.35-7.42 (1 H, m), 7.56-7.64 (1 H, m), 8.03 (2 H, d, J = 8.5
Hz), 8.04 (1 H, s), 8.18 (2 H, d, J = 8.5 Hz), 12.79 (1 H, bs) J-12
##STR00248## H Cl H 2.35 (3 H, d, J = 1.6 Hz), 7.51-7.56 (1 H, m),
7.84-7.92 (1 H, m), 8.03 (2 H, d, J = 8.5 Hz), 8.04 (1 H, s), 8.19
(2 H, d, J = 8.5 Hz), 12.83 (1 H, s), 13.84 (1 H, bs) J-13
##STR00249## H Cl H 2.53 (3 H, s), 7.44 (1 H, t, J = 7.9 Hz), 7.55-
7.59 (1 H, m), 7.69-7.72 (1 H, m), 7.92 (1 H, t, J = 1.8 Hz), 8.02
(2 H, d, J = 8.5 Hz), 8.04 (1 H, s), 8.19 (2 H, d, J = 8.5 Hz),
12.76 (1 H, bs), 13.80 (1 H, bs) J-14 ##STR00250## H Cl H 2.56 (3
H, s), 7.72-7.74 (2 H, m), 8.00-8.06 (5 H, m), 8.20 (2 H, d, J =
8.5 Hz), 12.77 (1 H, s), 13.75 (1 H, bs) J-15 ##STR00251## H Cl H
0.86-0.90 (3 H, m), 1.33-1.35 (4 H, m), 1.48-1.58 (2 H, m), 2.64 (2
H, t, J = 7.5 Hz), 2.98 (4 H, s), 7.08-7.09 (1 H, m), 7.20 (1 H, t,
J = 7.6 Hz), 7.63-7.66 (1 H, m), 8.03 (2 H, d, J = 8.5 Hz), 8.05 (1
H, s), 8.20 (2 H, d, J = 8.5 Hz), 12.81 (1 H, s), 13.79 (1 H, bs)
J-16 ##STR00252## H Cl H 13.80 (bs, 1 H), 13.20 (s, 1 H), 8.20 (d,
2 H, J = 8.5 Hz), 8.06 (s, 1 H), 8.04 (d, 2 H, J = 8.0 Hz), 7.75
(m, 1 H), 7.68 (m, 1 H), 7.42 (dd, 1 H, J = 8.2, 7.6 Hz), 7.26 (d,
1 H, J = 7.6 Hz), 2.65 (t, 2 H, J = 7.8 Hz), 1.50-1.70 (m, 2 H),
1.20-1.40 (m, 2 H), 0.92 (t, 3 H, J = 7.3 Hz) J-17 ##STR00253## H
Cl H 13.88 (bs, 1 H), 13.01 (s, 1 H), 8.10-8.24 (m, 4 H), 8.00-8.08
(m, 3 H), 7.74-7.80 (m, 2 H)
Example 6
##STR00254##
[0141] (Step 1)
[0142] A solution of compound (11) (1.1 g), compound (12) (760 mg),
potassium carbonate (1.44 g), tetrakistriphenylphosphinepalladium
(250 mg) in DMF was stirred at 110.degree.G for 2 h. The reaction
solution was poured into ethyl acetate, and the mixture was washed
with water four times and brine, dried over magnesium sulfate. The
solvent was concentrated, the residue was purified by silica gel
column chromatography (ethyl acetate/n-hexane=2/3) to obtain
compound (13) (870 mg) as a amorphous.
[0143] .sup.1H NMR (CDCl.sub.3, .delta. ppm): 4.06 (3H, s), 7.16
(1H, s), 7.28-7.50 (10H, m), 7.72 (1H, dd, J= 4.8 Hz, 1.8 Hz),
7.75-7.80 (2H, m), 8.25-8.30 (2H, m), 8.40 (1H, d, J=2.1 Hz).
(Step 2)
[0144] A solution of compound (13) (870 mg) in formic acid
(98-100%, 20 ml) was stirred at 50.degree. C. for 3 h. The reaction
solution was concentrated, toluene was added to the residue, and
concentrated again. The obtained residue was washed with isopropyl
ether to obtain compound (4) (473 mg) as white crystals.
[0145] .sup.1H NMR(CDCl.sub.3, .delta. ppm): 3.93 (3H, s),
7.97-8.02 (2H, m), 8.04 (1H, dd, J= 7.8 Hz, 1.8 Hz), 8.07-8.12 (2H,
m), 8.35 (1H, d, J= 1.5 Hz), 8.82 (1H, d. J= 4.8 Hz).
(Step 3)
[0146] Compound (K-14) was synthesized form compound (4) as
starting material in a manner similar to Step 4 of Example 1. Its
physical data was shown in Table 29.
(Step 4)
[0147] Compound (K-15) was synthesized form compound (K-14) as
starting material in a manner similar to Step 5 of Example 1. Its
physical data was shown in Table 29.
(Step 5)
[0148] A solution of compound (K-15) (100 mg),
diphenylphosphoroazide (55 .mu.l), triethylamine (351 .mu.l), and
tert-butanol (1 ml) in DMF (15 ml) was stirred at 100.degree. C.
for 1 h. The reaction solution was poured into ethyl acetate, THF
was added according to necessity when the precipitate was produced,
and the mixture was washed with water two times, sodium bicarbonate
aqueous solution and brine, dried over magnesium sulfate. The
solvent was concentrated, the residue was purified by silica gel
column chromatography (ethyl acetate/n-hexane=1/1) to obtain
compound (K-18) (60 mg) as white crystals.
[0149] Compound (K-16) to (K-17), and (K-19) were synthesized in a
manner similar to Example 6 and compound (K-1) to (K-13) in a
manner similar to Example 1. Their physical date were shown in
Table 29 to 31.
TABLE-US-00029 TABLE 29 ##STR00255## Com- pound No. R.sup.10 Y W
.sup.1H-NMR (DMSO d-6) K-1 ##STR00256## ##STR00257## --CONHMe 2.80
(3 H, d, J = 4.5 Hz), 7.00 (1 H, d, J = 15.8 Hz), 7.70-7.81 (4 H,
m), 7.89-7.93 (4 H, m),. 8.16 (1 H, d, J = 2.0 Hz), 8.53 (1 H, q, J
= 4.5 Hz), 12.62 (1 H, bs) K-2 ##STR00258## ##STR00259## --CONHMe
2.81 (3 H, d, J = 4.4 Hz), 7.02 (1 H, d, J = 15.8 Hz), 7.47-7.56 (1
H, m), 7.71-7.81 (5 H, m),. 7.90- 7.97 (3 H, m), 8.54 (1 H, q, J =
4.5 Hz), 12.60 (1 H, bs) K-3 ##STR00260## ##STR00261## --COOMe 3.88
(3 H, s), 7.03 (1 H, d, J = 15.9 Hz), 7.71 (1 H, d, J = 8.2 Hz),
7.76-7.83 (3 H, m), 7.89-7.92 (2 H, m), 8.03 (2 H, d, J = 8.2 Hz),
8.15 (1 H, d, J = 1.8 Hz), 12.66 (1 H, bs) K-4 ##STR00262##
##STR00263## --CONHMe 2.17 (3 H, d, J = 1.1 Hz), 2.80 (3 H, d, J =
4.5 Hz), 7.58 (2 H, d, J = 8.3 Hz), 7.62 (1 H, bs), 7.72 (1 H, d, J
= 8.4 Hz), 7.89-7.95 (4 H, m), 8.20 (1 H, d, J = 2.0 Hz), 8.53 (1
H, q, J = 4.5 Hz), 12.46 (1 H, bs) K-5 ##STR00264## ##STR00265##
--CONHMe 2.79 (3 H, d, J = 4.5 Hz), 7.16 (1 H, d, J = 24.2 Hz),
7.64 (2 H, d, J = 8.3 Hz), 7.71 (1 H, d, J = 8.5 Hz),. 7.81-7.83
(m, 2 H), 7.90-7.97 (m, 2 H), 8.18 (1 H, d, J = 1.7 Hz), 8.49 (1 H,
q, J = 4.5 Hz), 13.01 (1 H, bs) K-6 ##STR00266## ##STR00267##
--COOH 7.11 (1 H, d, J = 15.8 Hz), 7.69- 7.82 (4 H, m), 7.89-7.93
(2 H, m),. 8.02 (2 H, d, J = 8.1 Hz), 8.16 (1 H, d, J = 1.6 Hz),
12.72 (1 H, bs) K-7 ##STR00268## ##STR00269## --COOMe 2.59 (2 H, t,
J = 7.5 Hz), 3.04 (2 H, t, J = 7.5 Hz), 3.91 (3 H, s), 7.14- 7.17
(3 H, m), 7.43 (2 H, d, J = 8.7 Hz), 7.58 (1 H, dd, J = 8.7 Hz, 2.0
Hz), 7.87 (1 H, d, J = 2.0 Hz), 7.94 (2 H, d, J = 8.7 Hz), 9.87 (1
H, s) (CDCl3)
TABLE-US-00030 TABLE 30 Com- pound No. R.sup.10 Y W .sup.1H-NMR
(DMSO d-6) K-8 ##STR00270## ##STR00271## --COOH 2.82 (2 H, t, J =
7.2 Hz), 3.02 (2 H, t, J = 7.2 Hz), 7.38 (2 H, d, J = 8.5 Hz), 7.68
(1 H, d, J = 8.4 Hz), 7.83-7.89 (4 H, m), 8.12 (1 H, d, J = 2.0
Hz), 12.33 (1 H, s), 12.82 (1 H, s) K-9 ##STR00272## ##STR00273##
--SO.sub.2NH(t-Bu) (CDCl3) 1.26 (s, 9 H), 2.25 (d, 3 H, J = 1.5
Hz), 4.61 (s, 1 H), 7.21 (s, 1 H), 7.45 (d, 2 H, J = 8.5 Hz), 7.47
(d, 1 H, J = 8.2 Hz), 7.60 (brs, 1 H), 7.63 (dd, 1 H, J = 8.2, 1.8
Hz), 7.94 (d, 1 H, J = 1.8 Hz), 7.95 (d, 2 H, J = 8.5 Hz), 9.58
(brs, 1 H). K-10 ##STR00274## ##STR00275## --SO.sub.2NH.sub.2 2.14
(d, 3 H, J = 1.5 Hz), 7.42 (brs, 2 H), 7.59 (brs, 1 H), 7.65 (d, 2
H, J = 8.2 Hz), 7.69 (d, 1 H, J = 8.2 Hz), 7.86 (s, 1 H), 7.87 (d,
2 H, J = 8.2 Hz), 7.91 (dd, 1 H, J = 8.2, 2.1 Hz), 8.18 (d, 1 H, J
= 2.1 Hz), 12.47 (brs, 1 H). K-11 ##STR00276## ##STR00277##
--SO.sub.2NH(t-Bu) 1.11 (s, 9 H), 7.03 (d, 1 H, J = 16.2 Hz), 7.65
(s, 1 H), 7.67 (d, 1 H, J = 8.5 Hz), 7.80 (d, 1 H, J = 16.2 Hz),
7.81 (d, 2 H, J = 8.5 Hz), 7.89- 7.93 (m, 4 H), 8.17 (d, 1 H, J =
1.8 Hz), 12.67 (s, 1 H). K-12 ##STR00278## ##STR00279##
--SO.sub.2NH.sub.2 7.03 (d, 1 H, J = 16.0 Hz), 7.47 (2 H, s), 7.72
(d, 1 H, J = 8.5 Hz), 7.81 (d, 1 H, J = 16.0 Hz), 7.83 (d, 2 H, J =
8.4 Hz), 7.89 (d, 2 H, J = 8.4 Hz), 7.91 (s, 1 H), 7.91 (dd, 1 H, J
= 8.5, 2.1 Hz), 8.17 (d, 2 H, J = 2.1 Hz), 12.67 (s, 1 H). K-13
##STR00280## ##STR00281## --SO.sub.3H 6.94 (d, 1 H, J = 15.8 Hz),
7.60 (d, 2 H, J = 8.2 Hz), 7.67 (d, 2 H, J = 8.2 Hz), 7.72 (d, 1 H,
J = 8.2 Hz), 7.74 (d, 1 H, J = 15.8 Hz), 7.89 (s, 1 H), 7.91 (dd, 1
H, J = 8.2, 1.9 Hz), 8.16 (d, 1 H, J = 1.9 Hz), 12.57 (brs, 1 H).
K-14 ##STR00282## --NHCO-- ##STR00283## 3.94 (3 H, s), 7.72 (1 H,
d, J = 8.7 Hz), 7.93 (1 H, s), 7.95 (1 H, dd, J = 8.4 Hz, 1.8 Hz),
8.04-8.10 (3 H, m), 8.22 (1 H, d, J = 2.4 Hz), 8.30 (2 H, d, J =
8.4 Hz), 8.39 (1 H, d, J = 1.2 Hz), 12.93 (1 H, s) K-15
##STR00284## --NHCO-- ##STR00285## 7.71 (1 H, d, J = 8.4 Hz), 7.82
(1 H, bs), 7.89 (1 H, s), 7.93-8.01 (3 H, m), 8.22 (1 H, d, J = 2.1
Hz), 8.26-8.34 (3 H, m), 8.65 (1 H, bs)
TABLE-US-00031 TABLE 31 Com- pound No. R.sup.10 Y W .sup.1H-NMR
(DMSO d-6) K-16 ##STR00286## --NHCO-- ##STR00287## 3.53 (3 H, s),
5.26 (s, 1 H), 7.10 (1 H, ddd, J = 8.2 Hz, 2.5 Hz, 0.9 Hz), 7.21 (1
H, s), 7.22-7.28 (2 H, m), 7.36-7.40 (2 H, m), 7.55 (1 H, dd, J =
8.4 Hz, 2.0 Hz), 7.63 (2 H, d, J = 8.4 Hz), 7.83 (1 H, d, J = 2.0
Hz), 7.93 (2 H, d, J = 8.4 Hz), 10.86 (1 H, bs) (CDCl3) K-17
##STR00288## --NHCO-- ##STR00289## 6.82-6.86 (1 H, m), 7.12-7.13 (1
H, m), 7.17-7.20 (1 H, m), 7.28- 7.37 (1 H, m), 7.73 (1 H, d, J =
8.2 Hz), 7.89 (2 H, d, J = 8.5 Hz), 7.93 (1 H, s), 7.95 (1 H, dd, J
= 8.2 Hz, 2.0 Hz), 8.21 (2 H, d, J = 8.5 Hz), 8.23 (1 H, d, J = 2.0
Hz), 9.62 (1 H, s), 12.83 (1 H, s) K-18 ##STR00290## --NHCO--
##STR00291## 6.06 (2 H, s), 6.79 (1 H, s), 6.87 (1 H, d, J = 4.8
Hz), 7.73 (1 H, d, J = 8.4 Hz), 7.82 (2 H, d, J = 8.4 Hz), 7.93 (1
H, s), 7.96 (1 H, dd, J = 8.1 Hz, 1.5 Hz), 8.02 (1 H, d, J = 5.1
Hz), 8.21-8.27 (3 H, m), 12.88 (1 H, s) K-19 ##STR00292## --NHCO--
##STR00293## 3.06 (2 H, s), 7.28 (1 H, dt, 7.2 Hz, 2.1 Hz),
7.45-7.57 (3 H, m), 7.73 (1 H, d, J = 8.1 Hz), 7.81 (2 H, d, J =
8.4 Hz), 7.93 (1 H, s), 7.96 (1 H, dd, J = 8.4 Hz, 2.1 Hz), 8.21-
8.27 (3 H, m), 9.88 (1 H, bs), 12.84 (1 H, bs)
Example 7
The Preparation of Compounds (L-1, L-2)
##STR00294##
[0150] (Step 1)
(Step 1)
[0151] A solution of compound (15) (6.3 g), compound (16) (2.0 ml),
triethylamine (6.3 ml), tetrakistriphenylphosphinepalladium (870
mg), and copper (I) iodide (290 mg) in DMF (70 ml) was stirred at
90.degree. C. for 4 h. The reaction solution was poured into ethyl
acetate, and the mixture was washed with water four times and
brine, dried over magnesium sulfate. The solvent was concentrated,
the residue was purified by silica gel column chromatography (ethyl
acetate/n-hexane=1/4) to obtain compound (17) (2.25 g) as a
amorphous.
[0152] .sup.1H NMR (CDCl.sub.3, .delta. ppm): 3.81 (3H, s), 7.06
(1H, s), 7.28-7.42 (6H, m), 7.51-7.55 (4H, m), 7.85 (2H, d, J= 8.7
Hz), 8.17 (2H, d, J= 8.7 Hz).
(Step 2)
[0153] A solution of compound (17) (180 mg) and formic acid
(98-100%, 4 ml) in THF (4 ml) was stirred at room temperature for
18 h. The reaction solution was concentrated, toluene was added to
the residue, and concentrated again. The obtained residue was
washed with isopropyl ether to obtain compound (18) (95 mg) as
white needles.
[0154] .sup.1H NMR (CDCl.sub.3, .delta. ppm): 3.80 (3H, s), 7.79
(2H, d, J= 8.1 Hz), 8.00 (2H, d, J=8.1 Hz), 13.33 (1H, bs).
(Step 3)
[0155] Compound (L-1) was synthesized form compound (4) as starting
material in a manner similar to Step 4 of Example 1. Its physical
data was shown in Table 32.
(Step 4)
[0156] Compound (L-2) was synthesized form compound (L-1) as
starting material in a manner similar to Step 5 of Example 1. Its
physical data was shown in Table 32.
[0157] Compound (L-3) to (L-4) were synthesized in a manner similar
to Example. Their physical date were shown in Table 32.
TABLE-US-00032 TABLE 32 ##STR00295## Com- pound No. R.sup.10 Z
R.sup.5 .sup.1H-NMR (DMSO d-6) L-1 ##STR00296## ##STR00297## Me
3.82 (3 H, s), 7.72 (1 H, s), 7.85 (2 H, d, J = 8.7 Hz), 7.94 (1 H,
dd, J = 8.4 Hz, 2.1 Hz), 7.94 (1 H, s), 8.16-8.22 (3 H, m), 12.97
(1 H, s) L-2 ##STR00298## ##STR00299## H 7.72 (1 H, d, J = 8.4 Hz),
7.81 (2 H, d, J = 8.4 Hz), 7.95 (1 H, dd, J = 8.4 Hz, 2.1 Hz), 7.94
(1 H, s), 8.18 (2 H, d, J = 8.4 Hz), 8.21 (1 H, d, J = 2.1 Hz),
12.96 (1 H, s) L-3 ##STR00300## ##STR00301## Me 3.80 (3 H, s), 4.01
(3 H, s), 7.70-7.74 (3 H, m), 7.88 (1 H, s), 7.92-7.96 (2 H, m),
8.21 (1 H, d, J = 1.8 Hz), 12.99 (1 H, s) L-4 ##STR00302##
##STR00303## H 4.01 (3 H, s), 7.70-7.74 (3 H, m), 7.88 (1 H, s),
7.93-7.97 (2 H, m), 8.22 (1 H, d, J = 2.1 Hz), 12.98 (1 H, s),
13.75 (1 H, bs)
[0158] The below mentioned compounds were synthesized in a manner
similar to above described method.
##STR00304##
(Compound No., R.sup.a, R.sup.b, R.sup.c, R.sup.d, R.sup.e(M-1, H,
H, H, H, H), (M-2, H, H, H, H, Cl), (M-3, H, H, H, H, F), (M-4, H,
H, H, H, CF.sub.3), (M-5, H, H, H, H, Br), (M-6, H, H, H, H,
CH.sub.3), (M-7, H, H, H, F, H), (M-8, H, H, H, F, Cl), (M-9, H, H,
H, F, F), (M-10, H, H, H, F, CF.sub.3), (M-11, H, H, hi, F, Br),
(M-12, H, H, H, F, CH.sub.3), (M-13, H, H, H, Cl, H), (M-14, MeO,
H, H, Cl, Cl), (M-15, H, H, H, Cl, F), (M-16, H, H, H, Cl,
CF.sub.3), (M-17, H, H, H, Cl, Br), (M-18, H, H, H, Cl, CH.sub.3),
(M-19, H, H, H, CH.sub.3, H), (M-20, H, H, H, CH.sub.3, Cl), (M-21,
H, H, H, CH.sub.3, F), (M-22, H, H, H, CH.sub.3, CF.sub.3, (M-23,
H, H, H, CH.sub.3, Br), (M-24, H, H, H, CH.sub.3, CH.sub.3), (M-25,
H, H, H, Et, H), (M-26, H, H, H, Et, Cl), (M-27, H, H, H, Et, F),
(M-28, H, H, H, Et, CF.sub.3), (M-29, H, H, H, Et, Br), (M-30, H,
H, H, Et, CH.sub.3), (M-31, H, H, H, n-Pr, H), (M-32, H, H, H,
n-Pr, Cl), (M-33, H, H, H, n-Pr, F), (M-34, H, H, H, n-Pr,
CF.sub.3), (M-35, H, H, H, n-Pr, Br), (M-36, H, H, H, n-Pr,
CH.sub.3), (M-37, H, H, H, c-Pr, H), (M-38, H, H, H, c-Pr, Cl),
(M-39, H, H, H, c-Pr, F), (M-40, H, H, H, c-Pr, CF.sub.3), (M-41,
H, H, H, c-Pr, Br), (M-42, H, H, H, c-Pr, CH.sub.3), (M-43, H, H,
H, i-Pr, H), (M-44, H, H, H, i-Pr, Cl), (M-45, H, H, H, i-Pr, F),
(M-46, H, H, H, i-Pr, CF.sub.3), (M-47, H, H, H, i-Pr, Br), (M-48,
H, H, H, i-Pr, CH.sub.3), (M-49, H, H, H, n-Bu, H), (M-50, H, H, H,
n-Bu, Cl), (M-51, H, H, H, n-Bu, F), (M-52, H, H, H, n-Bu,
CF.sub.3), (M-53, H, H, H, n-Bu, Br), (M-54, H, H, H, n-Bu,
CH.sub.3), (M-55, H, H, H, i-Bu, H), (M-56, H, H, H, i-Bu, Cl),
(M-57, H, H, H, i-Bu, F), (M-58, H, H, H, i-Bu, CF.sub.3), (M-69,
H, H, H, i-Bu, Br), (M-60, H, H, H, i-Bu, CH.sub.3), (M-61, H, H,
H, sec-Bu, H), (M-62, H, H, H, sec-Bu, Cl), (M-63, H, H, H, sec-Bu,
F), (M-64, H, H, H, sec-Bu, CF.sub.3), (M-65, H, H, H, sec-Bu, Br),
(M-66, H, H, H, sec-Bu, CH.sub.3), (M-67, H, H, H, n-Pen, H),
(M-68, H, H, H, n-Pen, Cl), (M-69, H, H, H, n-Pen, F), (M-70, H, H,
H, n-Pen, CF.sub.3), (M-71, H, H, H, n-Pen, Br), (M-72, H, H, H,
n-Pen, CH.sub.3), (M-73, H, H, H, c-Pen, H), (M-74, H, H, H, c-Pen,
Cl), (M-75, H, H, H, c-Pen, F), (M-76, H, H, H, c-Pen, CF.sub.3),
(M-77, H, H, H, c-Pen, Br), (M-78, H, H, H, c-Pen, CH.sub.3),
(M-79, H, H, H, n-Hex, H), (M-80, H, H, H, n-Hex, Cl), (M-81, H, H,
H, n-Hex, F), (M-82, H, H, H, n-Hex, CF.sub.3), (M-83, H, H, H,
n-Hex, Br), (M-84, H, H, H, n-Hex, CH.sub.3), (M-85, H, H, H,
c-Hex, H), (M-86, H, H, H, c-Hex, Cl), (M-87, H, H, H, c-Hex, F),
(M-88, H, H, H, c-Hex, CF.sub.3), (M-89, H, H, H, c-Hex, Br),
(M-90, H, H, H, c-Hex, CH.sub.3), (M-91, H, H, H, OH, H), (M-92, H,
H, H, OH, Cl), (M-93, H, H, H, OH, F), (M-94, H, H, H, OH,
CF.sub.3), (M-95, H, H, H, OH, Br), (M-96, H, H, H, OH, CH.sub.3),
(M-97, H, H, H, EtO, H), (M-98, H, H, H, EtO, Cl), (M-99, H, H, H,
EtO, F), (M-100, H, H, H, EtO, CF.sub.3), (M-101, H, H, H, EtO,
Br), (M-102, H, H, H, EtO, CH.sub.3), (M-103, H, H, H, n-PrO, H),
(M-104, H, H, H, n-PrO, Cl), (M-105, H, H, H, n-PrO, F), (M-106, H,
H, H, n-PrO, CF.sub.3), (M-107, H, H, H, n-PrO, Br), (M-108, H, H,
H, n-PrO, CH.sub.3), (M-109, H, H, H, PhO, H), (M-110, H, H, H,
PhO, Cl), (M-111, H, H, H, PhO, F), (M-112, H, H, H, PhO,
CF.sub.3), (M-113, H, H, H, PhO, Br), (M-114, H, H, H, PhO,
CH.sub.3), (M-115, H, H, H, BnO, H), (M-116, H, H, H, BnO, Cl),
(M-117, H, H, H, BnO, F), (M-118, H, H, H, BnO, CF.sub.3), (M-119,
H, H, H, BnO, Br), (M-120, H, H, H, BnO, CH.sub.3), (M-121, H, H,
H, PhCH.sub.2CH.sub.2O, H), (M-122, H, H, H, PhCH.sub.2CH.sub.2O,
Cl), (M-123, H, H, H, PhCH.sub.2CH.sub.2O, F), (M-124, H, H, H,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-125, H, H, H,
PhCH.sub.2CH.sub.2O, Br), (M-126, H, H, H, PhCH.sub.2CH.sub.2O,
CH.sub.3), (M-127, H, H, H, CF.sub.3O, H), (M-128, H, H, H,
CF.sub.3O, Cl), (M-129, H, H, H, CF.sub.3O, F), (M-130, H, H, H,
CF.sub.3O, CF.sub.3), (M-131, H, H, H, CF.sub.3O, Br), (M-132, H,
H, H, CF.sub.3O, CH.sub.3), (M-133, H, H, H, Ph, H), (M-134, H, H,
H, Ph, Cl), (M-136, H, H, H, Ph, F), (M-136, H, H, H, Ph,
CF.sub.3), (M-137, H, H, H, Ph, Br), (M-138, H, H, H, Ph,
CH.sub.3), (M-139, H, H, H, 4-F-Ph, H), (M-140, H, H, H, 4-F-Ph,
Cl), (M-141, H, H, H, 4-F-Ph, F), (M-142, H, H, H, 4-F-Ph,
CF.sub.3), (M-143, H, H, H, 4-F-Ph, Br), (M-144, H, H, H, 4-F-Ph,
CH.sub.3), (M-145, H, H, H, 4-CF.sub.3-Ph, H), (M-146, H, H, H,
4-CF.sub.3-Ph, Cl), (M-147, H, H, H, 4-CF.sub.3-Ph, F), (M-148, H,
H, H, 4-CF.sub.3-Ph, CF.sub.3), (M-149, H, H, H, 4-CF.sub.3-Ph,
Br), (M-150, H, H, H, 4-CF.sub.3-Ph, CH.sub.3), (M-151, H, H, H,
4-(Me).sub.2N-Ph, H), (M-152, H, H, H, 4-(Me).sub.2N-Ph, Cl),
(M-153, H, H, H, 4-(Me).sub.2N-Ph, F), (M-154, H, H, H, 4,
(Me).sub.2N-Ph, CF.sub.3), (M-165, H, H, H, 4-(Me).sub.2N-Ph, Br),
(M-156, H, H, H, 4-(Me).sub.2N-Ph, CH.sub.2), (M-157, H, H, H,
4-OH-Ph, H), (M-158, H, H, H, 4-OH-Ph, Cl), (M-159, H, H, H,
4-OH-Ph, F), (M-160, H, H, H, 4-OH-Ph, CF.sub.3), (M-161, H, H, H,
4-OH-Ph, Br), (M-162, H, H, H, 4-OH-Ph, CH.sub.3), (M-163, H, H, H,
3,4-di-F-Ph, H), (M-164, H, H, H, 3,4-di-F-Ph, Cl), (M-165, H, H,
H, 3,4-di-F-Ph, F), (M-168, H, H, H, 3,4-di-F-Ph, CF.sub.3),
(M-167, H, H, H, 3,4-di-F-Ph, Br), (M-168, H, H, H, 3,4-di-F-Ph,
CH.sub.3), (M-169, H, H, H, 4-COOH-Ph, H), (M-170, H, H, H,
4-COOH-Ph, Cl), (M-171, H, H, H, 4-COOH-Ph, F), (M-172, H, H, H,
4-COOH-Ph, CF.sub.3), (M-173, H, H, H, 4-COOH-Ph, Br), (M-174, H,
H, H, 4-COOH-Ph, CH.sub.3), (M-175, H, H, H, Bn, H), (M-176, H, H,
H, Bn, Cl), (M-177, H, H, H, Bn, F), (M-178, H, H, H, Bn,
CF.sub.3), (M-179, H, H, H, Bn, Br), (M-180, H, H, H, Bn,
CH.sub.3), (M-181, H, H, H, 4-F-Bn, H), (M-182, H, H, H, 4-F-Bn,
Cl), (M-183, H, H, H, 4-F-Bn, F), (M-184, H, H, H, 4-F-Bn,
CF.sub.3), (M-185, H, H, H, 4-F-Bn, Br), (M-186, H, H, H, 4-F-Bn,
CH.sub.3), (M-187, H, H, H, 2-Py, H), (M-188, H, H, H, 2-Py, Cl),
(M-189, H, H, H, 2-Py, F), (M-190, H, H, H, 2-Py, CF.sub.3), M-191,
H, H, H, 2-Py, Br), (M-192, H, H, H, 2-Py, CH.sub.3), (M-193, H, H,
H, 3-Py, H), (M-194, H, H, H, 3-Py, Cl), (M-195, H, H, H, 3-Py, F),
(M-196, H, H, H, 3-Py, CF.sub.3), (M-197, H, H, H, 3-Py, Br),
(M-198, H, H, H, 3-Py, CH.sub.3), (M-199, H, H, H, 4-Py, H),
(M-200, H, H, H, 4-Py, Cl), (M-201, H, H, H, 4-Py, F), (M-202, H,
H, H, 4-Py, CF.sub.3), (M-203, H, H, H, 4-Py, Br), (M-204, H, H, H,
4-Py, CH.sub.3), (M-205, H, H, H, 2-Th, H), (M-206, H, H, H, 2-Th,
Cl), (M-207, H, H, H, 2-Th, F), (M-208, H, H, H, 2-Th, CF.sub.3),
(M-209, H, H, H, 2-Th, Br), (M-210, H, H, H, 2-Th, CH.sub.3),
(M-211, H, H, H, 3-Th, H), (M-212, H, H, H, 3-Th, Cl), (M-213, H,
H, H, 3-Th, F), (M-214, H, H, H, 3-Th, CF.sub.3), (M-215, H, H, H,
3-Th, Br), (M-216, H, H, H, 3-Th, CH.sub.3), (M-217, H, H, H,
pyrrazol-2-yl, H), (M-218, H, H, H, pyrrazol-2-yl, Cl), (M-219, H,
H, H, pyrrazol-2-yl, F), (M-220, 11, H, H, pyrrazol-2-yl,
CF.sub.3), (M-221, H, H, H, pyrrazol-2-yl, Br), (M-222, H, H, H,
pyrrazol-2-yl, CH.sub.3), (M-223, H, H, H, pyrrazol-3-yl, H),
(M-224, H, H, H, pyrrazol-3-yl, Cl), (M-225, H, H, H,
pyrrazol-3-yl, F), (M-226, H, H, H, pyrrazol-3-yl, CF.sub.3),
(M-227, H, H, H, pyrrazol-3-yl, Br), (M-228, H, H, H,
pyrrazol-3-yl, CH.sub.3), (M-229, H, H, H, pyrimidin-2-yl, H),
(M-230, H, H, H, pyrimidin-2-yl, Cl), (M-231, H, H, H,
pyrimidin-2-yl, F), (M-232, H, H, H, pyrimidin-2-yl, CF.sub.3),
(M-233, H, H, H, pyrimidin-2-yl, Br), (M-234, H, H, H,
pyrimidin-2-yl, CH.sub.3), (M-235, H, H, H, pyrimidin-4-yl, H),
(M-236, H, H, H, pyrimidin-4-yl, Cl), (M-237, H, H, H,
pyridine-4-yl, F), (M-238, H, H, H, pyrimidin-4-yl, CF.sub.3),
(M-239, H, H, H, pyrimidin-4-yl, Br), (M-240, H, H, H,
pyrimidin-4-yl, CH.sub.3), (M-241, H, H, H, pyrimidin-5-yl, H),
(M-242, H, H, H, pyrimidin-5-yl, Cl), (M-243, H, H, H,
pyrimidin-5-yl, F), (M-244, H, H, H, pyrimidin-5-yl, CF.sub.3),
(M-245, H, H, H, pyrimidin-5-yl, Br), (M-246, H, H, H,
pyrimidin-5-yl, CH.sub.3), (M-247, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-248, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-249, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-250, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-251, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-252, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-253, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-254, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-255, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-256, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-257, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-258, H, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-259, H, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-260, H, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2(Cl), (M-261, H, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-262, H, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-263,
H, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-264, H, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-265, H, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-266,
H, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Cl), (M-267, H, H, H,
(Me).sub.3NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-268,
H, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-269, H, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-270,
H, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-271, H, H, H, MeOCH.sub.2, H), (M-272, H, H, H,
MeOCH.sub.2, Cl), (M-273, H, H, H, MeOCH.sub.2, F), (M-274, H, H,
H, MeOCH.sub.2, CF.sub.3), (M-275, H, H, H, MeOCH.sub.2, Br),
(M-276, H, H, H, MeOCH.sub.2, CH.sub.3), (M-277, H, H, H,
EtOCH.sub.2, H), (M-278, H, H, H, EtOCH.sub.2, Cl), (M-279, H, H,
H, EtOCH.sub.2, F), (M-280, H, H, H, EtOCH.sub.2, CF.sub.3),
(M-281, H, H, H, EtOCH.sub.2, Br), (M-282, H, H, H, EtOCH.sub.2,
CH.sub.3), (M-283, H, H, H, EtOCH.sub.2CH.sub.2, H), (M-284, H, H,
H, EtOCH.sub.2CH.sub.2, Cl), (M-285, H, H, H, EtOCH.sub.2CH.sub.2,
F), (M-286, H, H, H, EtOCH.sub.2CH.sub.2, CF.sub.3), (M-287, H, H,
H, EtOCH.sub.2CH.sub.2, Br), (M-288, H, H, H, EtOCH.sub.2CH.sub.2,
CH.sub.3), (M-289, H, H, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
H), (M-290, H, H, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-291, H, H, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-292,
H, H, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-293,
H, H, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-294, H, H,
H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-295, H, H,
H, MeOCH.sub.2CH.sub.2, H), (M-296, H, H, H, MeOCH.sub.2CH.sub.2,
Cl), (M-297, H, H, H, MeOCH.sub.2CH.sub.2, F), (M-298, H, H, H,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-299, H, H, H,
MeOCH.sub.2CH.sub.2, Br), (M-300, H, H, H, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-301, H, H, H, HOCH.sub.2, H), (M-302, H, H, H,
HOCH.sub.2, Cl), (M-303, H, H, H, HOCH.sub.2, F), (M-304, H, H, H,
HOCH.sub.2, CF.sub.3), (M-305, H, H, H, HOCH.sub.2, Br), (M-306, H,
H, H, HOCH.sub.2, CH.sub.3), (M-307, H, H, H, HOCH.sub.2CH.sub.2,
H), (M-308, H, H, H, HOCH.sub.2CH.sub.2, Cl), (M-309, H, H, H,
HOCH.sub.2CH.sub.2, F), (M-310, H, H, H, HOCH.sub.2CH.sub.2,
CF.sub.3), (M-311, H, H, H, HOCH.sub.2CH.sub.2, Br), (M-312, H, H,
H, HOCH.sub.2CH.sub.2, CH.sub.3), (M-313, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-314, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-315, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-316, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-317, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-318, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-319, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-320, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-321, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-322, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-323, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-324, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-325, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-326, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-327, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-328, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-329, H,
H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-330, H,
H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-331, H, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-332,
H, H, H, HOCH.sub.2CH.sub.2OCH.sub.3CH.sub.2, Cl), (M-333, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-334, H, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-335, H, H, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-336, H, H, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-337, H, H, H,
(Me).sub.2N, H), (M-338, H, H, H, (Me).sub.2N, Cl), (M-339, H, H,
H, (Me).sub.2N, F), (M-340, H, H, H, (Me).sub.2N, CF.sub.3),
(M-341, H, H, H, (Me).sub.2N, Br), (M-342, H, H, H, (Me).sub.2N,
CH.sub.3), (M-343, H, H, H, piperidin-4-yl-methyl, H), (M-344, H,
H, H, piperidin-4-yl-methyl, Cl), (M-345, H, H, H,
piperidin-4-yl-methyl, F), (M-346, H, H, H, piperidin-4-yl-methyl,
CF.sub.3), (M-347, H, H, H, piperidin-4-yl-methyl, Br), (M-348, H,
H, H, piperidin-4-yl-methyl, CH.sub.3), (M-349, H, H, H,
cyclohexylmethyl, H), (M-350, H, H, H, cyclohexylmethyl, Cl),
(M-351, H, H, H, cyclohexylmethyl, F), (M-352, H, H, H,
cyclohexylmethyl, CF.sub.3), (M-353, H, H, H, cyclohexylmethyl,
Br), (M-354, H, H, H, cyclohexylmethyl, CH.sub.3), (M-355, H, H, F,
H, H), (M-356, H, H, F, H, Cl), (M-357, H, H, F, H, F), (M-358, H,
H, F, H, CF.sub.3), (M-359, H, H, F, H, Br), (M-360, H, H, F, H,
CH.sub.3), (M-361, H, H, F, F, H), (M-362, H, H, F, F, Cl), (M-363,
H, H, F, F, F), (M-364, H, H, F, F, CF.sub.3), (M-365, H, H, F, F,
Br), (M-366, H, H, F, F, CH.sub.3), (M-367, H, H, F, Cl, H),
(M-368, H, H, F, Cl, Cl), (M-369, H, H, F, Cl, F), (M-370, H, H, F,
Cl, CF.sub.3), (M-371, H, H, F, Cl, Br), (M-372, H, H, F, Cl,
CH.sub.3), (M-373, H, H, F, CH.sub.3, H), (M-374, H, H, F,
CH.sub.3, Cl), (M-375, H, H, F, CH.sub.3, F), (M-376, H, H, F,
CH.sub.3, CF.sub.3), (M-377, H, H, F, CH.sub.3, Br), (M-378, H, H,
F, CH.sub.3, CH.sub.3), (M-379, H, H, F, Et, H), (M-380, H, H, F,
Et, Cl), (M-381, H, H, F, Et, F), (M-382, H, H, F, Et, CF.sub.3),
(M-383, H, H, F, Et, Br), (M-384, H, H, F, Et, CH.sub.3), (M-385,
H, H, F, n-Pr, H), (M-386, H, H, F, n-Pr, Cl), (M-387, H, H, F,
n-Pr, F), (M-388, H, H, F, n-Pr, CF.sub.3), (M-389, H, H, F, n-Pr,
Br), (M-390, H, H, F, n-Pr, CH.sub.3), (M-391, H, H, F, c-Pr, H),
(M-392, H, H, F, c-Pr, Cl), (M-393, H, H, F, c-Pr, F), (M-394, H,
H, F, c-Pr, CF.sub.3), (M-395, H, H, F, c-Pr, Br), (M-396, H, H, F,
i-Pr, CH.sub.3), (M-397, H, H, F, i-Pr, H), (M-398, H, H, F, i-Pr,
Cl), (M-399, H, H, F, i-Pr, F), (M-400, H, H, F, i-Pr, CF.sub.3),
(M-401, H, H, F, i-Pr, Br), (M-402, H, H, F, i-Pr, CH.sub.3),
(M-403, H, H, F, n-Bu, H), (M-404, H, H, F, n-Bu, Cl), (M-405, H,
H, F, n-Bu, F), (M-406, H, H, F, n-Bu, CF.sub.3), (M-407, H, H, F,
n-Bu, Br), (M-408, H, H, F, n-Bu, CH.sub.3
), (M-409, H, H, F, i-Bu, H), (M-410, H, H, F, i-Bu, Cl), (M-411,
H, H, F, i-Bu, F), (M-412, H, H, F, i-Bu, CF.sub.3), (M-413, H, H,
F, i-Bu, Br), (M-414, H, H, F, i-Bu, CH.sub.3), (M-415, H, H, F,
sec-Bu, H), (M-416, H, H, F, sec-Bu, Cl), (M-417, H, H, F, sec-Bu,
F), (M-418, H, H, F, sec-Bu, CF.sub.3), (M-419, H, H, F, sec-Bu,
Br), (M-420, H, H, F, sec-Bu, CH.sub.3), (M-421, H, H, F, n-Pen,
H), (M-422, H, H, F, n-Pen, Cl), (M-423, H, H, F, n-Pen, F),
(M-424, H, H, F, n-Pen, CF.sub.3), (M-425, H, H, F, n-Pen, Br),
(M-426, H, H, F, n-Pen, CH.sub.3), (M-427, H, H, F, c-Pen, H),
(M-428, H, H, F, c-Pen, Cl), (M-429, H, H, F, c-Pen, F), (M-430, H,
H, F, c-Pen, CF.sub.3), (M-431, H, H, F, c-Pen, Br), (M-432, H, H,
F, c-Pen, CH.sub.3), (M-433, H, H, F, n-Hex, H), (M-434, H, H, F,
n-Hex, Cl), (M-435, H, H, F, n-Hex, F), (M-436, H, H, F, n-Hex,
CF.sub.3), (M-437, H, H, F, n-Hex, Br), (M-438, H, H, F, n-Hex,
CH.sub.3), (M-439, H, H, F, c-Hex, H), (M-440, H, H, F, c-Hex, Cl),
(M-441, H, H, F, c-Hex, F), (M-442, H, H, F, c-Hex, CF.sub.3),
(M-443, H, H, F, c-Hex, Br), (M-444, H, H, F, c-Hex, CH.sub.3),
(M-445, H, H, F, OH, H), (M-446, U, H, F, OH, Cl), (M-447, H, H, F,
OH, F), (M-448, H, H, F, OH, CF.sub.3), (M-449, H, H, F, OH, Br),
(M-450, H, H, F, OH, CH.sub.3), (M-451, H, H, F, EtO, H), (M-452,
H, H, F, EtO, Cl), (M-453, H, H, F, EtO, F), (M-454, H, H, F, EtO,
CF.sub.3), (M-455, H, H, F, EtO, Br), (M-456, H, H, F, EtO,
CH.sub.3), (M-457, H, H, F, n-PrO, H), (M-458, H, H, F, n-PrO, Cl),
(M-459, H, H, F, n-PrO, F), (M-460, H, H, F, n-PrO, CF.sub.3),
(M-461, H, H, F, n-PrO, Br), (M-462, H, H, F, n-PrO, CH.sub.3),
(M-463, H, H, F, PhO, H), (M-464, H, H, F, PhO, Cl), (M-465, H, H,
F, PhO, F), (M-466, H, H, F, PhO, CF.sub.3), (M-467, H, H, F, PhO,
Br), (M-468, H, H, F, PhO, CH.sub.3), (M-469, H, H, F, BnO, H),
(M-470, H, H, F, BnO, Cl), (M-471, H, H, F, BnO, F), (M-472, H, H,
F, BnO, CF.sub.3), (M-473, H, H, F, BnO, Br), (M-474, H, H, F, BnO,
CH.sub.3), (M-475, H, H, F, PhCH.sub.2CH.sub.2O, H), (M-476, H, H,
F, PhCH.sub.2CH.sub.2O, Cl), (M-477, H, H, F, PhCH.sub.2CH.sub.2O,
F), (M-478, H, H, F, PhCH.sub.2CH.sub.2O, CF.sub.3), (M-479, H, H,
F, PhCH.sub.2CH.sub.2O, Br), (M-480, H, H, F, PhCH.sub.2CH.sub.2O,
CH.sub.3), (M-481, H, H, F, CF.sub.3O, H), (M-482, H, H, F,
CF.sub.3O, Cl), (M-483, H, H, F, CF.sub.3O, F), (M-484, H, H, F,
CF.sub.3O, CF.sub.3), (M-485, H, H, F, CF.sub.3O, Br), (M-486, H,
H, F, CF.sub.3O, CH.sub.3), (M-487, H, H, F, Ph, H), (M-488, H, H,
F, Ph, Cl), (M-489, H, H, F, Ph, F), (M-490, H, H, F, Ph,
CF.sub.3), (M-491, H, H, F, Ph, Br), (M-492, H, H, F, Ph,
CH.sub.3), (M-493, H, H, F, 4-F-Ph, H), (M-494, H, H, F, 4-F-Ph,
Cl), (M-495, H, H, F, 4-F-Ph, F), (M-496, H, H, F, 4-F-Ph,
CF.sub.3), (M-497, H, H, F, 4-F-Ph, Br), (M-498, H, H, F, 4-F-Ph,
CH.sub.3), (M-499, H, H, F, 4-CF.sub.3-Ph, H), (M-500, H, H, F,
4-CF.sub.3-Ph, Cl), (M-501, H, H, F, 4-CF.sub.3-Ph, F), (M-502, H,
H, F, 4-CF.sub.3-Ph, CF.sub.3), (M-503, H, H, F, 4-CF.sub.3-Ph,
Br), (M-504, H, H, F, 4-CF.sub.3-Ph, CH.sub.3), (M-505, H, H, F,
4-(Me).sub.2N-Ph, H), (M-506, H, H, F, 4-(Me).sub.2N-Ph, Cl),
(M-507, H, H, F, 4-(Me).sub.2N-Ph, F), (M-508, H, H, F,
4-(Me).sub.2N-Ph, CF.sub.3), (M-509, H, H, F, 4-(Me).sub.2N-Ph,
Br), (M-510, H, H, F, 4-(Me).sub.2N-Ph, CH.sub.3), (M-511, H, H, F,
4-OH-Ph, H), (M-512, H, H, F, 4-OH-Ph, Cl), (M-513, H, H, F,
4-OH-Ph, F), (M-514, H, H, F, 4-OH-Ph, CF.sub.3), (M-515, H, H, F,
4-OH-Ph, Br), (M-516, H, H, F, 4-OH-Ph, CH.sub.3), (M-517, H, H, F,
3,4-di-F-Ph, H), (M-518, H, H, F, 3,4-di-F-Ph, Cl), (M-519, H, H,
F, 3,4-di-F-Ph, F), (M-520, H, H, F, 3,4-di-F-Ph, CF.sub.3),
(M-521, H, H, F, 3,4-di-F-Ph, Br), (M-522, H, H, F, 3,4-di-F-Ph,
CH.sub.3), (M-523, H, H, F, 4-COOH-Ph, H), (M-524, H, H, F,
4-COOH-Ph, Cl), (M-525, H, H, F, 4-COOH-Ph, F), (M-526, H, H, F,
4-COOH-Ph, CF.sub.3), (M-527, H, H, F, 4-COOH-Ph, Br), (M-528, H,
H, F, 4-COOH-Ph, CH.sub.3), (M-529, H, H, F, Bn, H), (M-530, H, H,
F, Bn, Cl), (M-531, H, H, F, Bn, F), (M-532, H, H, F, Bn,
CF.sub.3), (M-533, H, H, F, Bn, Br), (M-534, H, H, F, Bn,
CH.sub.3), (M-535, H, H, F, 4-F-Bn, H), (M-536, H, H, F, 4-F-Bn,
Cl), (M-537, H, H, F, 4-F-Bn, F), (M-538, H, H, F, 4-F-Bn,
CF.sub.3), (M-539, H, H, F, 4-F-Bn, Br), (M-540, H, H, F, 4-F-Bn,
CH.sub.3), (M-541, H, H, F, 2-Py, H), (M-542, H, H, F, 2-Py, Cl),
(M-543, H, H, F, 2-Py, F), (M-544, H, H, F, 2-Py, CF.sub.3),
(M-545, H, H, F, 2-Py, Br), (M-546, H, H, F, 2-Py, CH.sub.3),
(M-547, H, H, F, 3-Py, H), (M-548, H, H, F, 3-Py, Cl), (M-549, H,
H, F, 3-Py, F), (M-550, H, H, F, 3-Py, CF.sub.3), (M-551, H, H, F,
3-Py, Br), (M-552, H, H, F, 3-Py, CH.sub.3), (M-553, H, H, F, 4-Py,
H), (M-554, H, H, F, 4-Py, Cl), (M-555, H, H, F, 4-Py, F), (M-556,
H, H, F, 4-Py, CF.sub.3), (M-557, H, H, F, 4-Py, Br), (M-558, H, H,
F, 4-Py, CH.sub.3), (M-559, H, H, F, 2-Th, H), (M-560, H, H, F,
2-Th, Cl), (M-561, H, H, F, 2-Th, F), (M-562, H, H, F, 2-Th,
CF.sub.3), (M-563, H, H, F, 2-Th, Br), (M-564, H, H, F, 2-Th,
CH.sub.3), (M-565, H, H, F, 3-Th, H), (M-566, H, H, F, 3-Th, Cl),
(M-567, H, H, F, 3-Th, F), (M-568, H, H, F, 3-Th, CF.sub.3),
(M-569, H, H, F, 3-Th, Br), (M-570, H, H, F, 3-Th, CH.sub.3),
(M-571, H, H, F, pyrrazol-2-yl, H), (M-572, H, H, F, pyrrazol-2-yl,
Cl), (M-573, H, H, F, pyrrazol-2-yl, F), (M-574, H, H, F,
pyrrazol-2-yl, CF.sub.3), (M-575, H, H, F, pyrrazol-2-yl, Br),
(M-576, H, H, F, pyrrazol-2-yl, CH.sub.3), (M-577, H, H, F,
pyrrazol-3-yl, H), (M-578, H, H, F, pyrrazol-3-yl, Cl), (M-579, H,
H, F, pyrrazol-3-yl, F), (M-580, H, H, F, pyrrazol-3-yl, CF.sub.3),
(M-581, H, H, F, pyrrazol-3-yl, Br), (M-582, H, H, F,
pyrrazol-3-yl, CH.sub.3), (M-583, H, H, F, pyrimidine-2-yl, H),
(M-584, H, H, F, pyrimidin-2-yl, Cl), (M-585, H, H, F,
pyrimidin-2-yl, F), (M-586, H, H, F, pyrimidin-2-yl, CF.sub.3),
(M-587, H, H, F, pyrimidin-2-yl, Br), (M-588, H, H, F,
pyrimidin-2-yl, CH.sub.3), (M-589, H, H, F, pyrimidin-4-yl, H),
(M-590, H, H, F, pyrimidin-4-yl, Cl), (M-591, H, H, F,
pyrimidin-4-yl, F), (M-592, H, H, F, pyrimidin-4-yl, CF.sub.3),
(M-593, H, H, F, pyrimidin-4-yl, Br), (M-594, H, H, F,
pyrimidin-4-yl, CH.sub.3), (M-595, H, H, F, pyrimidin-5-yl, H),
(M-596, H, H, F, pyrimidin-5-yl, Cl), (M-597, H, H, F,
pyrimidin-5-yl, F), (M-598, H, H, F, pyrimidin-5-yl, CF.sub.3),
(M-599, H, H, F, pyrimidin-5-yl, Br), (M-600, H, H, F,
pyrimidin-5-yl, CH.sub.3), (M-601, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-602, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-603, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-604, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-605, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-606, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-607, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-608, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-609, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-610, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-611, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-612, H, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-613, H, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-614, H, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-615, H, H,
F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-616, H, H,
F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-617, H, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-618, H, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.aCH.sub.2CH.sub.2, CH.sub.2), (M-619,
H, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-620, H, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-621,
H, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-622, H, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-623, H, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-624,
H, H, F, (Me).sub.3NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.2), (M-625, H, H, F, MeOCH.sub.2, H), (M-626, H, H, F,
MeOCH.sub.2, Cl), (M-627, H, H, F, MeOCH.sub.2, F), (M-628, H, H,
F, MeOCH.sub.2, CF.sub.3), (M-629, H, H, F, MeOCH.sub.2, Br),
(M-630, H, H, F, MeOCH.sub.2, CH.sub.3), (M-631, H, H, F,
EtOCH.sub.2, H), (M-632, H, H, F, EtOCH.sub.2, Cl), (M-633, H, H,
F, EtOCH.sub.2, F), (M-634, H, H, F, EtOCH.sub.2, CF.sub.3),
(M-635, H, H, F, EtOCH.sub.2, Br), (M-636, H, Ft, F, EtOCH.sub.2,
CH.sub.3), (M-637, H, H, F, EtOCH.sub.2CH.sub.2, H), (M-638, H, H,
F, EtOCH.sub.2CH.sub.2, Cl), (M-639, H, H, F, EtOCH.sub.2CH.sub.2,
F), (M-640, H, H, F, EtOCH.sub.2CH.sub.2, CF.sub.3), (M-641, H, H,
F, EtOCH.sub.2CH.sub.2, Br), (M-642, H, H, F, EtOCH.sub.2CH.sub.2,
CH.sub.3), (M-643, H, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
H), (M-644, H, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-645, H, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-646,
H, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-647,
H, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-648, H, H,
F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-649, H, H,
F, MeOCH.sub.2CH.sub.2, H), (M-650, H, H, F, MeOCH.sub.2CH.sub.2,
Cl), (M-651, H, H, F, MeOCH.sub.2CH.sub.2, F), (M-652, H, H, F,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-653, H, H, F,
MeOCH.sub.2CH.sub.2, Br), (M-654, H, H, F, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-655, H, H, F, HOCH.sub.2, H), (M-656, H, H, F,
HOCH.sub.2, Cl), (M-657, H, H, F, HOC Ha, F), (M-658, H, H, F,
HOCH.sub.2, CF.sub.3), (M-659, H, H, F, HOCH.sub.2, Br), (M-660, H,
H, F, HOCH.sub.2, CH.sub.3), (M-661, H, H, F, HOCH.sub.2CH.sub.2,
H), (M-662, H, H, F, HOCH.sub.2CH.sub.2, Cl), (M-663, H, H, F,
HOCH.sub.2CH.sub.2, F), (M-664, H, H, F, HOCH.sub.2CH.sub.2,
CF.sub.3), (M-665, H, H, F, HOCH.sub.2CH.sub.2, Br), (M-666, H, H,
F, HOCH.sub.2CH.sub.2, CH.sub.3), (M-667, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-668, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-669, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-670, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.3, CF.sub.3), (M-671, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-672, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-673, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-674, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-675, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-676, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-677, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-678, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-679, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-680, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-681, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-682, H, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-683, H,
H, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-684, H,
H, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-685, H, H, F, HOCH.sub.2CH.sub.2OCH.sub.3CH.sub.2, H), (M-686,
H, H, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-687, H, H, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-688, H, H, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-689, H, H, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-690, H, H, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-691, H, H, F,
(Me).sub.2N, H), (M-692, H, H, F, (Me).sub.2N, Cl), (M-693, H, H,
F, (Me).sub.2N, F), (M-694, H, H, F, (Me).sub.2N, CF.sub.3),
(M-695, H, H, F, (Me).sub.2N, Br), (M-696, H, H, F, (Me).sub.2N,
CH.sub.3), (M-697, H, H, F, piperidin-4-ylmethyl, H), (M-698, H, H,
F, piperidin-4-yl-methyl, Cl), (M-699, H, H, F,
piperidin-4-yl-methyl, F), (M-700, H, H, F, piperidin-4-yl-methyl,
CF.sub.3), (M-701, H, H, F, piperidin-4-yl-methyl, Br), (M-702, H,
H, F, piperidin-4-yl-methyl, CH.sub.3), (M-703, H, H, F,
cyclohexylmethyl, H), (M-704, H, H, F, cyclohexylmethyl, Cl),
(M-705, H, H, F, cyclohexylmethyl, F), (M-706, H, H, F,
cyclohexylmethyl, CF.sub.3), (M-707, H, H, F, cyclohexylmethyl,
Br), (M-708, H, H, F, cyclohexylmethyl, CH.sub.3), (M-709, H, H,
Cl, H, H), (M-710, H, H, Cl, H, Cl), (M-711, H, H, Cl, H, F),
(M-712, H, H, Cl, H, CF.sub.3), (M-713, H, H, Cl, H, Br), (M-714,
H, H, Cl, H, CH.sub.3), (M-715, H, H, Cl, F, H), (M-716, H, H, Cl,
F, Cl), (M-717, H, H, Cl, F, F), (M-718, H, H, Cl, F, CF.sub.3),
(M-719, H, H, Cl, F, Br), (M-720, H, H, Cl, F, CH.sub.3), (M-721,
H, H, Cl, Cl, H), (M-722, H, H, Cl, Cl, Cl), (M-723, H, H, Cl, Cl,
F), (M-724, H, H, Cl, Cl, CF.sub.3), (M-725, H, H, Cl, Cl, Br),
(M-726, H, H, Cl, Cl, CH.sub.3), (M-727, H, H, H, CH.sub.3H),
(M-728, H, H, Cl, CH.sub.3, Cl), (M-729, H, H, Cl, CH.sub.3, F),
(M-730, H, H, Cl, CH.sub.3, CF.sub.3), (M-731, H, H, Cl, CH.sub.3,
Br), (M-732, H, H, Cl, CH.sub.3, CH.sub.3), (M-733, H, H, Cl, Et,
H), (M-734, H, H, Cl, Et, Cl), (M-735, H, H, Cl, Et, F), (M-736, H,
H, Cl, Et, CF.sub.3), (M-737, H, H, Cl, Et, Br), (M-738, H, H, Cl,
Et, CH.sub.3), (M-739, H, H, Cl, n-Pr, H), (M-740, H, H, Cl, n-Pr,
Cl), (M-741, H, H, Cl, n-Pr, F), (M-742, H, H, Cl, n-Pr, CF.sub.3),
(M-743, H, H, Cl, n-Pr, Br), (M-744, H, H, Cl, n-Pr, CH.sub.3),
(M-745, H, H, Cl, c-Pr, H), (M-746, H, H, Cl, c-Pr, Cl), (M-747, H,
H, Cl, c-Pr, F), (M-748, H, H, Cl, c-Pr, CF.sub.3), (M-749, H, H,
Cl, c-Pr, Br), (M-750, H, H, Cl, c-Pr, CH.sub.3), (M-751, H, H, Cl,
i-Pr, H), (M-752, H, H, Cl, i-Pr, Cl), (M-753, H, H, Cl, i-Pr, F),
(M-754, H, H, Cl, i-Pr, CF.sub.3), (M-755, H, H, Cl, i-Pr, Br),
(M-756, H, H, Cl, i-Pr, CH.sub.3), (M-757, H, H, Cl, n-Bu, H),
(M-758, H, H, Cl, n-Bu, Cl), (M-759, H, H, Cl, n-Bu, F), (M-760, H,
H, Cl, n-Bu, CF.sub.3), (M-761, H, H, Cl, n-Bu, Br), (M-762, H, H,
Cl, n-Bu, CH.sub.3), (M-763, H, H, Cl, i-Bu, H), (M-764, H, H, Cl,
i-Bu, Cl), (M-765, H, H, Cl, i-Bu, F), (M-766, H, H, Cl, i-Bu,
CF.sub.3), (M-767, H, H, Cl, i-Bu, Br), (M-768, H, H, Cl, i-Bu,
CH.sub.3), (M-769, H, H, Cl, sec-Bu, H), (M-770, H, H, Cl, sec-Bu,
Cl), (M-771, H, H, Cl, sec-Bu, F), (M-772, H, H, Cl, sec-Bu,
CF.sub.3), (M-773, H, H, Cl, sec-Bu, Br), (M-774, H, H, Cl, sec-Bu,
CH.sub.3), (M-775, H, H, Cl, n-Pen, H), (M-776, H, H, Cl, n-Pen,
Cl), (M-777, H, H, Cl, n-Pen, F), (M-778, H, H, Cl, n-Pen,
CF.sub.3), (M-779, H, H, Cl, n-Pen, Br), (M-780, H, H, Cl, n-Pen,
CH.sub.3), (M-781, H, H, Cl, c-Pen, H), (M-782, H, H, Cl, c-Pen,
Cl), (M-783, H, H, Cl, c-Pen, F), (M-784, H, H, Cl, c-Pen,
CF.sub.3), (M-785, H, H, Cl, c-Pen, Br), (M-786, H, H, Cl, c-Pen,
CH.sub.3), (M-787, H, H, Cl, n-Hex, H), (M-788, H, H, Cl, n-Hex,
Cl), (M-789, H, H, Cl, n-Hex, F), (M-790, H, H, Cl, n-Hex,
CF.sub.3), (M-791, H, H, Cl, n-Hex, Br), (M-792, H, H, Cl, n-Hex,
CH.sub.3), (M-793, H, H, Cl, c-Hex, H), (M-794, H, H, Cl, c-Hex,
Cl), (M-795, H, H, Cl, c-Hex, F), (M-796, H, H, Cl, c-Hex,
CF.sub.3), (M-797, H, H, Cl, c-Hex, Br), (M-798, H, H, Cl, c-Hex,
CH.sub.3), (M-799, H, H, Cl, OH, H), (M-800, H, H, Cl, OH, Cl),
(M-801, H, H, Cl, OH, F), (M-802, H, H, Cl, OH, CF.sub.3), (M-803,
H, H, Cl, OH, Br), (M-804, H, H, Cl, OH, CH.sub.3), (M-805, H, H,
Cl, EtO, H), (M-806, H, H, Cl, EtO, Cl), (M-807, H, H, Cl, EtO, P),
(M-808, H, H, Cl, EtO, CF.sub.3), (M-809, H, H, Cl, EtO, Br),
(M-810, H, H, Cl, EtO, CH
.sub.3), (M-811, H, H, Cl, n-PrO, H), (M-812, H, H, Cl, n-PrO, Cl),
(M-813, H, H, Cl, n-PrO, F), (M-814, H, H, Cl, n-PrO, CF.sub.3),
(M-815, H, H, Cl, n-PrO, Br), (M-816, H, H, Cl, n-PrO, CH.sub.3),
(M-817, H, H, Cl, PhO, H), (M-818, H, H, Cl, PhO, Cl), (M-819, H,
H, Cl, PhO, F), (M-820, H, H, Cl, PhO, CF.sub.3), (M-821, H, H, Cl,
PhO, Br), (M-822, H, H, Cl, PhO, CH.sub.3), (M-823, H, H, Cl, BnO,
H), (M-824, H, H, Cl, BnO, Cl), (M-825, H, H, Cl, BnO, F), (M-826,
H, H, Cl, BnO, CF.sub.3), (M-827, H, H, Cl, BnO, Br), (M-828, H, H,
Cl, BnO, CH.sub.3), (M-829, H, H, Cl, PhCH.sub.2CH.sub.2O, H),
(M-830, H, H, Cl, PhCH.sub.2CH.sub.2O, Cl), (M-831, H, H, Cl,
PhCH.sub.2CH.sub.2O, F), (M-832, H, H, Cl, PhCH.sub.2CH.sub.2O,
CF.sub.3), (M-833, H, H, Cl, PhCH.sub.2CH.sub.2O, Br), (M-834, H,
H, Cl, PhCH.sub.2CH.sub.2O, CH.sub.3), (M-835, H, H, Cl, CF.sub.3O,
H), (M-836, H, H, Cl, CF.sub.3O, Cl), (M-837, H, H, Cl, CF.sub.3O,
F), (M-838, H, H, Cl, CF.sub.3O, CF.sub.3), (M-839, H, H, Cl,
CF.sub.3O, Br), (M-840, H, H, Cl, CF.sub.3O, CH.sub.3), (M-841, H,
H, Cl, Ph, H), (M-842, H, H, Cl, Ph, Cl), (M-843, H, H, Cl, Ph, F),
(M-844, H, H, Cl, Ph, CF.sub.3), (M-845, H, H, Cl, Ph, Br), (M-846,
H, H, Cl, Ph, CH.sub.3), (M-847, H, H, Cl, 4-F-Ph, H), (M-848, H,
H, Cl, 4-F-Ph, Cl), (M-849, H, H, Cl, 4-F-Ph, F), (M-850, H, H, Cl,
4-F-Ph, CF.sub.3), (M-851, H, H, Cl, 4-F-Ph, Br), (M-852, H, H, Cl,
4-F-Ph, CH.sub.3), (M-853, H, H, Cl, 4-CF.sub.3-Ph, H), (M-854, H,
H, Cl, 4-CF.sub.3-Ph, Cl), (M-855, H, H, Cl, 4-CF.sub.3-Ph, F),
(M-856, H, H, Cl, 4-CF.sub.3-Ph, CF.sub.3), (M-857, H, H, Cl,
4-CF.sub.3-Ph, Br), (M-858, H, H, Cl, 4-CF.sub.3-Ph, CH.sub.3),
(M-859, H, H, Cl, 4-(Me).sub.2N-Ph, H), (M-860, H, H, Cl,
4-(Me).sub.2N-Ph, Cl), (M-861, H, H, Cl, 4-(Me).sub.2N-Ph, F),
(M-862, H, H, Cl, 4-(Me).sub.2N-Ph, CF.sub.3), (M-863, H, H, Cl,
4-(Me).sub.2N-Ph, Br), (M-864, H, H, Cl, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-865, H, H, Cl, 4-OH-Ph, H), (M-866, H, H, Cl,
4-OH-Ph, Cl), (M-867, H, H, Cl, 4-OH-Ph, F), (M-868, H, H, Cl,
4-OH-Ph, CF.sub.3), (M-869, H, H, Cl, 4-OH-Ph, Br), (M-870, H, H,
Cl, 4-OH-Ph, CH.sub.3), (M-871, H, H, Cl, 3,4-di-F-Ph, H), (M-872,
H, H, Cl, 3,4-di-F-Ph, Cl), (M-873, H, H, Cl, 3,4-di-F-Ph, F),
(M-874, H, H, Cl, 3,4-di-F-Ph, CF.sub.3), (M-875, H, H, Cl,
3,4-di-F-Ph, Br), (M-876, H, H, Cl, 3,4-di-F-Ph, CH.sub.3), (M-877,
H, H, Cl, 4-COOH-Ph, H), (M-878, H, H, Cl, 4-COOH-Ph, Cl), (M-879,
H, H, Cl, 4-COOH-Ph, F), (M-880, H, H, Cl, 4-COOH-Ph, CF.sub.3),
(M-881, H, H, Cl, 4-COOH-Ph, Br), (M-882, H, H, Cl, 4-COOH-Ph,
CH.sub.3), (M-883, H, H, Cl, Bn, H), (M-884, H, H, Cl, Bn, Cl),
(M-885, H, H, Cl, Bn, F), (M-886, H, H, Cl, Bn, CF.sub.3), (M-887,
H, H, Cl, Bn, Br), (M-888, H, H, CL, Bn, CH.sub.3), (M-889, H, H,
Cl, 4-F-Bn, H), (M-890, H, H, Cl, 4-F-Bn, Cl), (M-891, H, H, Cl,
4-F-Bu, F), (M-892, H, H, Cl, 4-F-Bn, CF.sub.3), (M-893, H, H, Cl,
4-F-Bn, Br), (M-894, H, H, Cl, 4-F-Bn, CH.sub.3), (M-895, H, H, Cl,
2-Py, H), (M-896, H, H, Cl, 2-Py, Cl), (M-897, H, H, Cl, 2-Py, F),
(M-898, H, H, Cl, 2-Py, CF.sub.3), (M-899, H, H, Cl, 2-Py, Br),
(M-900, H, H, Cl, 2-Py, CH.sub.3), (M-901, H, H, Cl, 3-Py, H),
(M-902, H, H, Cl, 3-Py, Cl), (M-903, H, H, Cl, 3-Py, F), (M-904, H,
H, Cl, 3-Py, CF.sub.3), (M-905, H, H, Cl, 3-Py, Br), (M-906, H, H,
Cl, 3-Py, CH.sub.3), (M-907, H, H, Cl, 4-Py, H), (M-908, H, H, Cl,
4-Py, Cl), (M-909, H, H, Cl, 4-Py, F), (M-910, H, H, Cl, 4-Py,
CF.sub.3), (M-911, H, H, Cl, 4-Py, Br), (M-912, H, H, Cl, 4-Py,
CH.sub.3), (M-913, H, H, Cl, 2-Th, H), (M-914, H, H, Cl, 2-Th, Cl),
(M-915, H, H, Cl, 2-Th, F), (M-916, H, H, Cl, 2-Th, CF.sub.3),
(M-917, H, H, Cl, 2-Th, Br), (M-918, H, H, Cl, 2-Th, CH.sub.3),
(M-919, H, H, Cl, 3-Th, H), (M-920, H, H, Cl, 3-Th, Cl), (M-921, H,
H, Cl, 3-Th, F), (M-922, H, H, Cl, 3-Th, CF.sub.3), (M-923, H, H,
Cl, 3-Th, Br), (M-924, H, H, Cl, 3-Th, CH.sub.3), (M-925, H, H, Cl,
pyrrazol, 2-yl, H), (M-926, H, H, Cl, pyrrazol-2-yl, Cl), (M-927,
H, H, Cl, pyrrazol-2-yl, F), (M-928, H, H, Cl, pyrrazol-2-yl,
CF.sub.3), (M-929, H, H, Cl, pyrrazol-2-yl, Br), (M-930, H, H, Cl,
pyrrazol-2-yl, CH.sub.3), (M-931, H, H, Cl, pyrrazol-3-yl, H),
(M-932, H, H, Cl, pyrrazol-3-yl, Cl), (M-933, H, H, Cl,
pyrrazol-3-yl, F), (M-934, H, H, Cl, pyrrazol-2-yl, CF.sub.3),
(M-935, H, H, Cl, pyrrazol-3-yl, Br), (M-936, H, H, Cl,
pyrrazol-3-yl, CH.sub.3), (M-937, H, H, Cl, pyrimidin-2-yl, H),
(M-938, H, H, Cl, pyrimidin-2-yl, Cl), (M-939, H, H, Cl,
pyrimidin-2-yl, F), (M-940, H, H, Cl, pyrimidin-2-yl, CF.sub.3),
(M-941, H, H, Cl, pyrimidin-2-yl, Br), (M-942, H, H, Cl,
pyrimidin-2-yl, CH.sub.2), (M-943, H, H, Cl, pyrimidin-4-yl, H),
(M-944, H, H, Cl, pyrimidin-4-yl, Cl), (M-945, H, H, Cl,
pyrimidin-4-yl, F), (M-946, H, H, Cl, pyrimidin-4-yl, CF.sub.3),
(M-947, H, H, Cl, pyrimidin-4-yl, Br), (M-948, H, H, Cl,
pyrimidin-4-yl, CH.sub.3), (M-949, H, H, Cl, pyrimidin-5-yl, H),
(M-950, H, H, Cl, pyrimidin-5-yl, Cl), (M-951, H, H, Cl,
pyrimidin-5-yl, F), (M-952, H, H, Cl, pyrimidin-5-yl, CF.sub.3),
(M-953, H, H, Cl, pyrimidin-5-yl, Br), (M-954, H, H, Cl,
pyrimidin-5-yl, CH.sub.3), (M-955, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-956, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-957, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-958, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-959, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-960, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-961, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-962, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-963, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-964, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-965, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-966, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-967, H, H, Cl,
(Me).sub.2NCOCH.sub.3CH.sub.2CH.sub.2CF.sub.2, H), (M-968, H, H,
Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-969, H,
H, Cl, (Me).sub.2NCOCH.sub.3CH.sub.2CH.sub.2CH.sub.2, F), (M-970,
H, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-971, H, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-972, H, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-973,
H, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
H), (M-974, H, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-975,
H, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
F), (M-976, H, H, Cl,
(Me.sub.2NCOC).sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-977, H, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-978,
H, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-979, H, H, Cl, MeOCH.sub.2, H), (M-980, H, H, Cl,
MeOCH.sub.2, Cl), (M-981, H, H, Cl, MeOCH.sub.2, F), (M-982, H, H,
Cl, MeOCH.sub.2, CF.sub.3), (M-983, H, H, Cl, MeOCH.sub.2, Br),
(M-984, H, H, Cl, MeOCH.sub.2, CH.sub.2), (M-985, H, H, Cl,
EtOCH.sub.2, H), (M-986, H, H, Cl, EtOCH.sub.2, Cl), (M-987, H, H,
Cl, EtOCH.sub.2, F), (M-988, H, H, Cl, EtOCH.sub.2, CF.sub.3),
(M-989, H, H, Cl, EtOCH.sub.2, Br), (M-990, H, H, Cl, EtOCH.sub.2,
CH.sub.3), (M-991, H, H, Cl, EtOCH.sub.2CH.sub.2, H), (M-992, H, H,
Cl, EtOCH.sub.2CH.sub.2, Cl), (M-993, H, H, Cl,
EtOCH.sub.2CH.sub.2, F), (M-994, H, H, Cl, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-995, H, H, Cl, EtOCH.sub.2CH.sub.2, Br), (M-996, H,
H, Cl, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-997, H, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-998, H, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-999, H, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-1000, H, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-1001, H, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-1002, H, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-1003, H, H, Cl,
MeOCH.sub.2CH.sub.2, H), (M-1004, H, H, Cl, MeOCH.sub.2CH.sub.2,
Cl), (M-1005, H, H, Cl, MeOCH.sub.2CH.sub.2, F), (M-1006, H, H, Cl,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-1007, H, H, Cl,
MeOCH.sub.2CH.sub.2, Br), (M-1008, H, H, Cl, MeOCH.sub.2CH.sub.2,
CH.sub.2), (M-1009, H, H, Cl, HOCH.sub.2, H), (M-1010, H, H, Cl,
HOCH.sub.2, Cl), (M-1011, H, H, Cl, HOCH.sub.2, F), (M-1012, H, H,
Cl, HOCH.sub.2, CF.sub.3), (M-1013, H, H, Cl, HOCH.sub.2, Br),
(M-1014, H, H, Cl, HOCH.sub.2, CH.sub.3), (M-1015, H, H, Cl,
HOCH.sub.2CH.sub.2, H), (M-1016, H, H, Cl, HOCH.sub.2CH.sub.2, Cl),
(M-1017, H, H, Cl, HOCH.sub.2CH.sub.2, F), (M-1018, H, H, Cl,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-1019, H, H, Cl,
HOCH.sub.2CH.sub.2, Br), (M-1020, H, H, Cl, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-1021, H, H, Cl, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-1022, H, H, Cl, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-1023, H, H,
Cl, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-1024, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1025, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-1026, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.2), (M-1027, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-1028, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-1029, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1030, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1031, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-1032, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-1033, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-1034, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-1035, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1036, H, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1037, H,
H, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-1038, H,
H, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-1039, H, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H),
(M-1040, H, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-1041, H, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-1042, H, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-1043, H, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br)
(M-1044, H, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-1045, H, H, Cl, (Me).sub.2N, H), (M-1046, H, H, Cl, (Me).sub.2N,
Cl), (M-1047, H, H, Cl, (Me).sub.3N, F), (M-1048, H, H, Cl,
(Me).sub.2N, CF.sub.3), (M-1049, H, H, Cl, (Me).sub.2N, Br),
(M-1050, H, H, Cl, (Me).sub.2N, CH.sub.3), (M-1051, H, H, Cl,
piperidin-4-yl-methyl, H), (M-1052, H, H, Cl,
piperidin-4-yl-methyl, Cl), (M-1053, H, H, Cl,
piperidin-4-yl-methyl, F), (M-1054, H, H, Cl,
piperidin-4-yl-methyl, CF.sub.3), (M-1055, H, H, Cl,
piperidin-4-yl-methyl, Br), (M-1056, H, H, Cl,
piperidin-4-yl-methyl, CH.sub.3), (M-1057, H, H, Cl,
cyclohexylmethyl, H), (M-1058, H, H, Cl, cyclohexylmethyl, Cl),
(M-1059, H, H, Cl, cyclohexylmethyl, F), (M-1060, H, H, Cl,
cyclohexylmethyl, CF.sub.3), (M-1061, H, H, Cl, cyclohexylmethyl,
Br), (M-1062, H, H, Cl, cyclohexylmethyl, CH.sub.3), (M-1063, H, F,
H, H, H), (M-1064, H, F, H, H, Cl), (M-1065, H, F, H, H, F),
(M-1066, H, F, H, H, CF.sub.3), (M-1067, H, F, H, H, Br), (M-1068,
H, F, H, H, CH.sub.3), (M-1069, H, F, H, F, H), (M-1070, H, F, H,
F, Cl), (M-1071, H, F, H, F, F), (M-1072, H, F, H, F, CF.sub.3),
(M-1073, H, F, H, F, Br), (M-1074, H, F, H, F, CH.sub.3), (M-1075,
H, F, H, Cl, H), (M-1076, H, F, H, Cl, Cl), (M-1077, H, F, H, Cl,
F), (M-1078, H, F, H, Cl, CF.sub.3), (M-1079, H, F, H, Cl, Br),
(M-1080, H, F, H, Cl, CH.sub.2), (M-1081, H, F, H, CH.sub.2, H),
(M-1082, H, F, H, CH.sub.2, Cl), (M-1083, H, F, H, CH.sub.2, F),
(M-1084, H, F, H, CH.sub.2, CF.sub.3), (M-1085, H, F, H, CH.sub.2,
Br), (M-1086, H, F, H, CH.sub.3, CH.sub.3), (M-1087, H, F, H, Et,
H), (M-1088, H, F, H, Et, Cl), (M-1089, H, F, H, Et, F), (M-1090,
H, F, H, Et, CF.sub.3), (M-1091, H, F, H, Et, Br), (M-1092, H, F,
H, Et, CH.sub.3), (M-1093, H, F, H, n-Pr, H), (M-1094, H, F, H,
n-Pr, Cl), (M-1095, H, F, H, n-Pr, F), (M-1096, H, F, H, n-Pr,
CF.sub.3), (M-1097, H, F, H, n-Pr, Br), (M-1098, H, F, H, n-Pr,
CH.sub.3), (M-1099, H, F, H, c-Pr, H), (M-1100, H, F, H, c-Pr, Cl),
(M-1101, H, F, H, c-Pr, F), (M-1102, H, F, H, c-Pr, CF.sub.3),
(M-1103, H, F, H, c-Pr, Br), (M-1104, H, F, H, c-Pr, CH.sub.3),
(M-1105, H, F, H, i-Pr, H), (M-1106, H, F, H, i-Pr, Cl), (M-1107,
H, F, H, i-Pr, F), (M-1108, H, F, H, i-Pr, CF.sub.3), (M-1109, H,
F, H, i-Pr, Br), (M-1110, H, F, H, i-Pr, CH.sub.3), (M-1111, H, F,
H, n-Bu, H), (M-1112, H, F, H, n-Bu, Cl), (M-1113, H, F, H, n-Bu,
F), (M-1114, H, F, H, n-Bu, CF.sub.3), (M-1115, H, F, H, n-Bu, Br),
(M-1116, H, F, H, n-Bu, CH.sub.3), (M-1117, H, F, H, i-Bu, H),
(M-1118, H, F, H, i-Bu, Cl), (M-1119, H, F, H, i-Bu, F), (M-1120,
H, F, H, i-Bu, CF.sub.3), (M-1121, H, F, H, i-Bu, Br), (M-1122, H,
F, H, i-Bu, CH.sub.3), (M-1123, H, F, H, sec-Bu, H), (M-1124, H, F,
H, sec-Bu, Cl), (M-1125, H, F, H, sec-Bu, F), (M-1126, H, F, H,
sec-Bu, CF.sub.3), (M-1127, H, F, H, sec-Bu, Br), (M-1128, H, F, H,
sec-Bu, CH.sub.3), (M-1129, H, F, H, n-Pen, H), (M-1130, B, F, H,
n-Pen, Cl), (M-1131, H, F, H, n-Pen, F), (M-1132, H, F, H, n-Pen,
CF.sub.3), (M-1133, H, F, H, n-Pen, Br), (M-1134, H, F, H, n-Pen,
CH.sub.2), (M-1135, H, F, H, c-Pen, H), (M-1136, H, F, H, c-Pen,
Cl), (M-1137, H, F, H, c-Pen, F), (M-1138, H, F, H, c-Pen,
CF.sub.3), (M-1139, H, F, H, c-Pen, Br), (M-1140, H, F, H, c-Pen,
CH.sub.3), (M-1141, H, F, H, n-Hex, H), (M-1142, H, F, H, n-Hex,
Cl), (M-1143, H, F, H, n-Hex, F), (M-1144, H, F, H, n-Hex,
CF.sub.3), (M-1145, H, F, H, n-Hex, Br), (M-1146, H, F, H, n-Hex,
CH.sub.3), (M-1147, H, F, H, c-Hex, H), (M-1148, H, F, H, c-Hex,
Cl), (M-1149, H, F, H, c-Hex, F), (M-1150, H, F, H, c-Hex,
CF.sub.3), (M-1151, H, F, H, c-Hex, Br), (M-1152, H, F, H, c-Hex,
CH.sub.2), (M-1153, H, F, H, OH, H), (M-1154, H, F, H, OH, Cl),
(M-1155, H, F, H, OH, F), (M-1156, H, F, H, OH, CF.sub.3), (M-1157,
H, F, H, OH, Br), (M-1158, H, F, H, OH, CH.sub.3), (M-1159, H, F,
H, EtO, H), (M-1160, H, F, H, EtO, Cl), (M-1161, H, F, H, EtO, F),
(M-1162, H, F, H, EtO, CF.sub.3), (M-1163, H, F, H, EtO, Br),
(M-1164, H, F, H, EtO, CH.sub.3), (M-1165, H, F, H, n-PrO, H),
(M-1166, H, F, H, n-PrO, Cl), (M-1167, H, F, H, n-PrO, F), (M-1168,
H, F, H, n-PrO, CF.sub.3), (M-1169, H, F, H, n-PrO, Br), (M-1170,
H, F, H, n-PrO, CH.sub.2), (M-1171, H, F, H, PhO, H), (M-1172, H,
F, H, PhO, Cl), (M-1173, H, F, H, PhO, F), (M-1174, H, F, H, PhO,
CF.sub.3), (M-1175, H, F, H, PhO, Br), (M-1176, H, F, H, PhO,
CH.sub.3), (M-1177, H, F, H, BnO, H), (M-1178, H, F, H, BnO, Cl),
(M-1179, H, F, H, BnO, F), (M-1180, H, F, H, BnO, CF.sub.3),
(M-1181, H, F, H, BnO, Br), (M-1182, H, F, H, BnO, CH.sub.2),
(M-1183, H, F, H, PhCH.sub.2CH.sub.2O, H), (M-1184, H, F, H,
PhCH.sub.2CH.sub.2O, Cl), (M-1185, H, F, H, PhCH.sub.2CH.sub.2O,
F), (M-1186, H, F, H, PhCH.sub.2CH.sub.2O, CF.sub.3), (M-1187, H,
F, H, PhCH.sub.2CH.sub.2O, Br), (M-1188, H, F, H,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-1189, H, F, H, CF.sub.3O, H),
(M-1190, H, F, H, CF.sub.3, Cl), (M-1191, H, F, H, CF.sub.3O, F),
(M-1192, H, F, H, CF.sub.3O, CF.sub.3), (M-1193, H, F, H,
CF.sub.3O, Br), (M-1194, H, F, H, CF.sub.3O, CH.sub.3), (M-1195, H,
F, H, Ph, H, (M-1196, H, F, H, Ph, Cl), (M-1197, H, F, H, Ph, F),
(M-1198, H, F, H, Ph, CF
.sub.3), (M-1199, H, F, H, Ph, Br), (M-1200, H, F, H, Ph,
CH.sub.3), (M-1201, H, F, H, 4-F-Ph, H), (M-1202, H, F, H, 4-F-Ph,
Cl), (M-1203, H, F, H, 4-F-Ph, F), (M-1204, H, F, H, 4-F-Ph,
CF.sub.3), (M-1205, H, F, H, 4-F-Ph, Br), (M-1206, H, F, H, 4-F-Ph,
CH.sub.3), (M-1207, H, F, H, 4-CF.sub.2-Ph, H), (M-1208, H, F, H,
4-CF.sub.3-Ph, Cl), (M-1209, H, F, H, 4-CF.sub.2-Ph, F), (M-1210,
H, F, H, 4-CF.sub.3-Ph, CF.sub.3), (M-1211, H, F, H, 4-CF.sub.3-Ph,
Br), (M-1212, H, F, H, 4-CF.sub.3-Ph, CH.sub.3), (M-1213, H, F, H,
4-(Me).sub.2N-Ph, H), (M-1214, H, F, H, 4-(Me).sub.2N-Ph, Cl),
(M-1215, H, F, H, 4-(Me).sub.2N-Ph, F), (M-1216, H, F, H,
4-(Me).sub.2N-Ph, CF.sub.3), (M-1217, H, F, H, 4-(Me).sub.2N-Ph,
Br), (M-1218, H, F, H, 4-(Me).sub.2N-Ph, CH.sub.3), (M-1219, H, F,
H, 4-OH-Ph, H), (M-1220, H, F, H, 4-OH-Ph, Cl), (M-1221, H, F, H,
4-OH-Ph, F), (M-1222, H, F, H, 4-OH-Ph, CF.sub.3), (M-1223, H, F,
H, 4-OH-Ph, Br), (M-1224, H, F, H, 4-OH-Ph, CH.sub.3), (M-1225, H,
F, H, 3,4-di-F-Ph, H), (M-1226, H, F, H, 3,4-di-F-Ph, Cl), (M-1227,
H, F, H, 3,4-di-F-Ph, F), (M-1228, H, F, H, 3,4-di-F-Ph, CF.sub.3),
(M-1229, H, F, H, 3,4-di-F-Ph, Br), (M-1230, H, F, H, 3,4-di-F-Ph,
CH.sub.3), (M-1231, H, F, H, 4-COOH-Ph, H), (M-1232, H, F, H,
4-COOH-Ph, Cl), (M-1233, H, F, H, 4-COOH-Ph, F), (M-1234, H, F, H,
4-COOH-Ph, CF.sub.3), (M-1235, H, F, H, 4-COOH-Ph, Br), (M-1236, H,
F, H, 4-COOH-Ph, CH.sub.3), (M-1237, H, F, H, Bn, H), (M-1238, H,
F, H, Bn, Cl), (M-1239, H, F, H, Bn, F), (M-1240, H, F, H, Bn,
CF.sub.3), (M-1241, H, F, H, Bn, Br), (M-1242, H, F, H, Bn,
CH.sub.3), (M-1243, H, F, H, 4-F-Bn, H), (M-1244, H, F, H, 4-F-Bn,
Cl), (M-1245, H, F, H, 4-F-Bn, F), (M-1246, H, F, H, 4-F-Bn,
CF.sub.3), (M-1247, H, F, H, 4-F-Bn, Br), (M-1248, H, F, H, 4-F-Bn,
CH.sub.3), (M-1249, H, F, H, 2-Py, H), (M-1250, H, F, H, 2-Ph, Cl),
(M-1251, H, F, H, 2-Py, F), (M-1252, H, F, H, 2-Py, CF.sub.3),
(M-1253, H, F, H, 2-Py, Br), (M-1254, H, F, H, 2-Py, CH.sub.3),
(M-1255, H, F, H, 3-Py, H), (M-1256, H, F, H, 3-Py, Cl), (M-1257,
H, F, H, 3-Py, F), (M-1258, H, F, H, 3-Py, CF.sub.3), (M-1259, H,
F, H, 3-Py, Br), (M-1260, H, F, H, 3-Py, CH.sub.3), (M-1261, H, F,
H, 4-Py, H), (M-1262, H, F, H, 4-Py, Cl), (M-1263, H, F, H, 4-Py,
F), (M-1264, H, F, H, 4-Py, CF.sub.3), (M-1265, H, F, H, 4-Py, Br),
(M-1266, H, F, H, 4-Py, CH.sub.3), (M-1267, H, F, H, 2-Th, H),
(M-1268, H, F, H, 2-Th, Cl), (M-1269, H, F, H, 2-Th, F), (M-1270,
H, F, H, 2-Th, CF.sub.3), (M-1271, H, F, H, 2-Th, Br), (M-1272, H,
F, H, 2-Th, CH.sub.3), (M-1273, H, F, H, 3-Th, H), (M-1274, H, F,
H, 3-Th, Cl), (M-1275, H, F, H, 3-Th, F), (M-1276, H, F, H, 3-Th,
CF.sub.3), (M-1277, H, F, H, 3-Th, Br), (M-1278, H, F, H, 3-Th,
CH.sub.3), (M-1279, H, F, H, pyrrazol-2-yl, H), (M-1280, H, F, H,
pyrrazol-2-yl, Cl), (M-1281, H, F, H, pyrrazol-2-yl, F), (M-1282,
H, F, H, pyrrazol-2-yl, CF.sub.3), (M-1283, H, F, H, pyrrazol-2-yl,
Br), (M-1284, H, F, H, pyrrazol-2-yl, CH.sub.3), (M-1285, H, F, H,
pyrrazol-3-yl, H), (M-1286, H, F, H, pyrrazol-3-yl, Cl), (M-1287,
H, F, H, pyrrazol-3-yl, F), (M-1288, H, F, H, pyrrazol-3-yl,
CF.sub.3), (M-1289, H, F, H, pyrrazol-3-yl, Br), (M-1290, H, F, H,
pyrrazol-3-yl, CH.sub.3), (M-1291, H, F, H, pyrimidin, 2-yl, H),
(M-1292, H, F, H, pyrimidin-2-yl, Cl), (M-1293, H, F, H,
pyrimidin-2-yl, F), (M-1294, H, F, H, pyrimidin-2-yl, CF.sub.3),
(M-1295, H, F, H, pyrimidin-2-yl, Br), (M-1296, H, F, H,
pyrimidin-2-yl, CH.sub.3), (M-1297, H, F, H, pyrimidin-4-yl, H),
(M-1298, H, F, H, pyrimidin-4-yl, Cl), (M-1299, H, F, H,
pyrimidin-4-yl, F), (M-1300, H, F, H, pyrimidin-4-yl, CF.sub.3),
(M-1301, H, F, H, pyrimidin-4-yl, Br), (M-1302, H, F, H,
pyrimidin-4-yl, CH.sub.3), (M-1303, H, F, H, pyrimidin-5-yl, H),
(M-1304, H, F, H, pyrimidin-5-yl, Cl), (M-1305, H, F, H,
pyrimidin-5-yl, F), (M-1306, H, F, H, pyrimidin-5-yl, CF.sub.3),
(M-1307, H, F, H, pyrimidin-5-yl, Br), (M-1308, H, F, H,
pyrimidin-5-yl, CH.sub.3), (M-1309, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.3, H), (M-1310, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-1311, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-1312, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1313, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-1314, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.2), (M-1315, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-1316, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-1317, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1318, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1319, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-1320, H, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-1321, H, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-1322, H, F,
H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-1323, H,
F, H, (Me).sub.3NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1324,
H, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-1325, H, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-1326, H, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-1327,
H, F, H, (Me.sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-1328, H, F, H,
(Me).sub.2NCOCH.sub.3CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-1329, H, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1330,
H, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-1331, H, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-1332, H, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-1333, H, F, H, MeOCH.sub.2, H), (M-1334, H, F, H, MeOCH.sub.2,
Cl), (M-1335, H, F, H, MeOCH.sub.2, F), (M-1336, H, F, H,
MeOCH.sub.2, CF.sub.3), (M-1337, H, F, H, MeOCH.sub.2, Br),
(M-1338, H, F, H, MeOCH.sub.2, CH.sub.3), (M-1339, H, F, H,
EtOCH.sub.2, H), (M-1340, H, F, H, EtOCH.sub.2, Cl), (M-1341, H, F,
H, EtOCH.sub.2, F), (M-1342, H, F, H, EtOCH.sub.2, CF.sub.3),
(M-1343, H, F, H, EtOCH.sub.2, Br), (M-1344, H, F, H, EtOCH.sub.2,
CH.sub.3), (M-1345, H, F, H, EtOCH.sub.2CH.sub.2, H), (M-1346, H,
F, H, EtOCH.sub.2CH.sub.2, Cl), (M-1347, H, F, H,
EtOCH.sub.2CH.sub.2, F), (M-1348, H, F, H, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-1349, H, F, H, EtOCH.sub.2CH.sub.2, Br), (M-1350, H,
F, H, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-1351, H, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-1352, H, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-1353, H, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-1354, H, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-1355, H, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-1356, H, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.1CH.sub.2, CH.sub.3), (M-1357, H, F, H,
MeOCH.sub.2CH.sub.2, H), (M-1358, H, F, H, MeOCH.sub.2CH.sub.2,
Cl), (M-1359, H, F, H, MeOCH.sub.2CH.sub.2, F), (M-1360, H, F, H,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-1361, H, F, H,
MeOCH.sub.2CH.sub.2, Br), (M-1362, H, F, H, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-1363, H, F, H, HOCH.sub.2, H), (M-1364, H, F, H,
HOCH.sub.2, Cl), (M-1365, H, F, H, HOCH.sub.2, F), (M-1366, H, F,
H, HOCH.sub.2, CF.sub.3), (M-1367, H, F, H, HOCH.sub.2, Br),
(M-1368, H, F, H, HOCH.sub.2, CH.sub.3), (M-1369, H, F, H,
HOCH.sub.2CH.sub.2, H), (M-1370, H, F, H, HOCH.sub.2CH.sub.2, Cl),
(M-1371, H, F, H, HOCH.sub.2CH.sub.2, F), (M-1372, H, F, H,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-1373, H, F, H,
HOCH.sub.2CH.sub.2, Br), (M-1374, H, F, H, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-1375, H, F, H, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-1376, H, F, H, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-1377, H, F,
H, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-1378, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1379, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-1380, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-1381, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-1382, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-1383, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1384, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1385, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-1386, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.2), (M-1387, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3, H), (M-1388, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-1389, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1390, H, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1391, H,
F, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-1392, H,
F, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-1393, H, F, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-1394,
H, F, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-1395, H, F,
H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-1396, H, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-1397, H, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-1398, H, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-1399, H, F, H,
(Me).sub.2N, H), (M-1400, H, F, H, (Me).sub.2N, Cl), (M-1401, H, F,
H, (Me).sub.2N, F), (M-1402, H, F, H, (Me).sub.2N, CF.sub.3),
(M-1403, H, F, H, (Me).sub.2N, Br), (M-1404, H, F, H, (Me).sub.2N,
CH.sub.3), (M-1405, H, F, H, piperidin-4-yl-methyl, H), (M-1406, H,
F, H, piperidin-4-yl-methyl, Cl), (M-1407, H, F, H,
piperidin-4-yl-methyl, F), (M-1408, H, F, H, piperidin-4-yl-methyl,
CF.sub.3), (M-1409, H, F, H, piperidin-4-yl-methyl, Br), (M-1410,
H, F, H, piperidin-4-yl-methyl, CH.sub.3), (M-1411, H, F, H,
cyclohexylmethyl, H), (M-1412, H, F, H, cyclohexylmethyl, Cl),
(M-1413, H, F, H, cyclohexylmethyl, F), (M-1414, H, F, H,
cyclohexylmethyl, CF.sub.3), (M-1415, H, F, H, cyclohexylmethyl,
Br), (M-1416, H, F, H, cyclohexylmethyl, CH.sub.3), (M-1417, H, F,
F, H, H), (M-1418, H, F, F, H, Cl), (M-1419, H, F, F, H, F),
(M-1420, H, F, F, H, CF.sub.3), (M-1421, H, F, F, H, Br), (M-1422,
H, F, F, H, CH.sub.3), (M-1423, H, F, F, F, H), (M-1424, H, F, F,
F, Cl), (M-1425, H, F, F, F, F), (M-1426, H, F, F, F, CF.sub.3),
(M-1427, H, F, F, F, Br), (M-1428, H, F, F, F, CH.sub.3), (M-1429,
H, F, F, Cl, H), (M-1430, H, F, F, Cl, Cl), (M-1431, H, F, F, Cl,
F), (M-1432, H, F, F, Cl, CF.sub.3), (M-1433, H, F, F, Cl, Br),
(M-1434, H, F, F, Cl, CH.sub.3), (M-1435, H, F, F, CH.sub.3, H),
(M-1436, H, F, F, CH.sub.3, Cl), (M-1437, H, F, F, CH.sub.3, F),
(M-1438, H, F, F, CH.sub.3, CF.sub.3), (M-1439, H, F, F, CH.sub.3,
Br), (M-1440, H, F, F, CH.sub.3, CH.sub.3), (M-1441, H, F, F, Et,
H), (M-1442, H, F, F, Et, Cl), (M-1443, H, F, F, Et, F), (M-1444,
H, F, F, Et, CF.sub.3), (M-1445, H, F, F, Et, Br), (M-1446, H, F,
F, Et, CH.sub.3), (M-1447, H, F, F, n-Pr, H), (M-1448, H, F, F,
n-Pr, Cl), (M-1449, H, F, F, n-Pr, F), (M-1450, H, F, F, n-Pr,
CF.sub.3), (M-1451, H, F, F, n-Pr, Br), (M-1452, H, F, F, n-Pr,
CH.sub.3), (M-1453, H, F, F, c-Pr, H), (M-1454, H, F, F, c-Pr, Cl),
(M-1455, H, F, F, c-Pr, F), (M-1456, H, F, F, c-Pr, CF.sub.3),
(M-1457, H, F, F, c-Pr, Br), (M-1458, H, F, F, c-Pr, CH.sub.3),
(M-1459, H, F, F, i-Pr, H), (M-1460, H, F, F, i-Pr, Cl), (M-1461,
H, F, F, i-Pr, F), (M-1462, H, F, F, i-Pr, CF.sub.3), (M-1463, H,
F, F, i-Pr, Br), (M-1464, H, F, F, i-Pr, CH.sub.3), (M-1465, H, F,
F, n-Bu, H), (M-1466, H, F, F, n-Bu, Cl), (M-1467, H, F, F, n-Bu,
F), (M-1468, H, F, F, n-Bu, CF.sub.3), (M-1469, H, F, F, n-Bu, Br),
(M-1470, H, F, F, n-Bu, CH.sub.3), (M-1471, H, F, F, i-Bu, H),
(M-1472, H, F, F, i-Bu, Cl), (M-1473, H, F, F, i-Bu, F), (M-1474,
H, F, F, i-Bu, CF.sub.3), (M-1475, H, F, F, i-Bu, Be), (M-1476, H,
F, F, i-Bu, CH.sub.3), (M-1477, H, F, F, sec-Bu, H), (M-1478, H, F,
F, sec-Bu, Cl), (M-1479, H, F, F, sec-Bu, F), (M-1480, H, F, F,
sec-Bu, CF.sub.3), (M-1481, H, F, F, sec-Bu, Br), (M-1482, H, F, F,
sec-Bu, CH.sub.3), (M-1483, H, F, F, n-Pen, H), (M-1484, H, F, F,
n-Pen, Cl), (M-1485, H, F, F, n-Pen, F), (M-1486, H, F, F, n-Pen,
CF.sub.3), (M-1487, H, F, F, n-Pen, Br), (M-1488, H, F, F, n-Pen,
CH.sub.3), (M-1489, H, F, F, c-Pen, H), (M-1490, H, F, F, c-Pen,
Cl), (M-1491, H, F, F, c-Pen, F), (M-1492, H, F, F, c-Pen,
CF.sub.3), (M-1493, H, F, F, c-Pen, Br), (M-1494, H, F, F, c-Pen,
CH.sub.3), (M-1495, H, F, F, n-Hex, H), (M-1496, H, F, F, n-Hex,
Cl), (M-1497, H, F, F, n-Hex, F), (M-1498, H, F, F, n-Hex,
CF.sub.3), (M-1499, H, F, F, n-Hex, Br), (M-1500, H, F, F, n-Hex,
CH.sub.3), (M-1501, H, F, F, c-Hex, H), (M-1502, H, F, F, c-Hex,
Cl), (M-1503, H, F, F, c-Hex, F), (M-1504, H, F, F, c-Hex,
CF.sub.3), (M-1505, H, F, F, c-Hex, Br), (M-1506, H, F, F, c-Hex,
CH.sub.3), (M-1507, H, F, F, OH, H), (M-1508, H, F, F, OH, Cl),
(M-1509, H, F, F, OH, F), (M-1510, H, F, F, OH, CF.sub.3), (M-1511,
H, F, F, OH, Br), (M-1512, H, F, F, OH, CH.sub.3), (M-1513, H, F,
F, EtO, H), (M-1514, H, F, F, EtO, Cl), (M-1515, H, F, F, EtO, F),
(M-1516, H, F, F, EtO, CF.sub.3), (M-1517, H, F, F, EtO, Br),
(M-1518, H, F, F, EtO, CH.sub.3), (M-1519, H, F, F, n-PrO, H),
(M-1520, H, F, F, n-PrO, Cl), (M-1521, H, F, F, n-PrO, F), (M-1522,
H, F, F, n-PrO, CF.sub.3), (M-1523, H, F, F, n-PrO, Br), (M-1524,
H, F, F, n-PrO, CH.sub.3), (M-1525, H, F, F, PhO, H), (M-1526, H,
F, F, PhO, Cl), (M-1527, H, F, F, PhO, F), (M-1528, H, F, F, PhO,
CF.sub.3), (M-1529, H, F, F, PhO, Br), (M-1530, H, F, F, PhO,
CH.sub.3), (M-1531, H, F, F, BnO, H), (M-1532, H, F, F, BnO, Cl),
(M-1533, H, F, F, BnO, F), (M-1534, H, F, F, BnO, CF.sub.3),
(M-1535, H, F, F, BnO, Br), (M-1536, H, F, F, BnO, CH.sub.3),
(M-1537, H, F, F, PhCH.sub.2CH.sub.2O, H), (M-1538, H, F, F,
PhCH.sub.2CH.sub.2O, Cl), (M-1539, H, F, F, PhCH.sub.2CH.sub.3O,
F), (M-1540, H, F, F, PhCH.sub.2CH.sub.2O, CF.sub.3), (M-1541, H,
F, F, PhCH.sub.2CH.sub.2O, Br), (M-1542, H, F, F,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-1543, H, F, F, CF.sub.3O, H),
(M-1544, H, F, F, CF.sub.3O, Cl), (M-1545, H, F, F, CF.sub.3O, F),
(M-1546, H, F, F, CF.sub.3O, CF.sub.3), (M-1547, H, F, F,
CF.sub.3O, Br), (M-1548, H, F, F, CF.sub.3O, CH.sub.3), (M-1549, H,
F, F, Ph, H), (M-1550, H, F, F, Ph, Cl), (M-1551, H, F, F, Ph, F),
(M-1552, H, F, F, Ph, CF.sub.3), (M-1553, H, F, F, Ph, Br),
(M-1554, H, F, F, Ph, CH.sub.3), (M-1555, H, F, F, 4-F-Ph, H),
(M-1556, H, F, F, 4-F-Ph, Cl), (M-1557, H, F, F, 4-F-Ph, F),
(M-1558, H, F, F, 4-F-Ph, CF.sub.3), (M-1559, H, F, F, 4-F-Ph, Br),
(M-1560, H, F, F, 4-F-Ph, CH.sub.3), (M-1561, H, F, F,
4-CF.sub.2-Ph, H), (M-1562, H, F, F, 4-CF.sub.2-Ph, Cl), (M-1563,
H, F, F, 4-CF.sub.2, Ph, F), (M-1564, H, F, F, 4-CF.sub.3-Ph,
CF.sub.3), (M-1565, H, F, F, 4-CF.sub.2-Ph, Br), (M-1566, H, F, F,
4-CF.sub.3-Ph, CH.sub.3), (M-1567, H, F, F, 4-(Me).sub.2N-Ph, H),
(M-1568, H, F, F, 4-(Me).sub.2N-Ph, Cl), (M-1569, H, F, F,
4-(Me).sub.2N-Ph, F), (M-1570, H, F, F, 4-(Me).sub.2N-Ph,
CF.sub.3), (M-1571, H, F, F, 4-(Me).sub.2N-Ph, Br), (M-1572, H, F,
F, 4-(Me).sub.2N-Ph, CH.sub.3), (M-1573, H, F, F, 4-OH-Ph, H),
(M-1574, H, F, F, 4-OH-Ph, Cl), (M-1575, H, F, F, 4-OH-Ph, F),
(M-1576, H, F, F, 4-OH-Ph, CF.sub.3), (M-1577, H, F, F, 4-OH-Ph,
Br), (M-1578, H, F, F, 4-OH-Ph, CH.sub.3), (M-1579, H, F, F,
3,4-di-F-Ph, H), (M-1580, H, F, F, 3,4-di-F-Ph, Cl), (M-1581, H, F,
F, 3,4-di-F-Ph, F), (M-1582, H, F, F, 3,4-di-F-Ph, CF.sub.3),
(M-1583, H, F, F, 3,4-di-F-Ph, Br), (M-1584, H, F, F, 3,4-di-F-Ph,
CH
.sub.3), (M-1585, H, F, F, 4-COOH-Ph, H), (M-1586, H, F, F,
4-COOH-Ph, Cl), (M-1587, H, F, F, 4-COOH-Ph, F), (M-1588, H, F, F,
4-COOH-Ph, CF.sub.3), (M-1589, H, F, F, 4-COOH-Ph, Br), (M-1590, H,
F, F, 4-COOH-Ph, CH.sub.3), (M-1591, H, F, F, Bn, H), (M-1592, H,
F, F, Bn, Cl), (M-1593, H, F, F, Bn, F), (M-1594, H, F, F, Bn,
CF.sub.3), (M-1595, H, F, F, Bn, Br), (M-1596, H, F, F, Bn,
CH.sub.3), (M-1597, H, F, F, 4-F-Bn, H), (M-1598, H, F, F, 4-F-Bn,
Cl), (M-1599, H, F, F, 4-F-Bn, F), (M-1600, H, F, F, 4-F-Bn,
CF.sub.3), (M-1601, H, F, F, 4-F-Bn, Br), (M-1602, H, F, F, 4-F-Bn,
CH.sub.3), (M-1603, H, F, F, 2-Py, H), (M-1604, H, F, F, 2-Py, Cl),
(M-1605, H, F, F, 2-Py, F), (M-1606, H, F, F, 2-Py, CF.sub.3),
(M-1607, H, F, F, 2-Py, Br), (M-1608, H, F, F, 2-Py, CH.sub.3),
(M-1609, H, F, F, 3-Py, H), (M-1610, H, F, F, 3-Py, Cl), (M-1611,
H, F, F, 3-Py, F), (M-1612, H, F, F, 3-Py, CF.sub.3), (M-1613, H,
F, F, 3-Py, Br), (M-1614, H, F, F, 3-Py, CH.sub.3), (M-1615, H, F,
F, 4-Py, H), (M-1616, H, F, F, 4-Py, Cl), (M-1617, H, F, F, 4-Py,
F), (M-1618, H, F, F, 4-Py, CF.sub.3), (M-1619, H, F, F, 4-Py, Br),
(M-1620, H, F, F, 4-Py, CH.sub.3), (M-1621, H, F, F, 2-Th, H),
(M-1622, H, F, F, 2-Th, Cl), (M-1623, B, F, F, 2-Th, F), (M-1624,
H, F, F, 2-Th, CF.sub.3), (M-1625, H, F, F, 2-Th, Br), (M-1626, H,
F, F, 2-Th, CH.sub.3), (M-1627, H, F, F, 3-Th, H), (M-1628, H, F,
F, 3-Th, Cl), (M-1629, H, F, F, 3-Th, F), (M-1630, H, F, F, 3-Th,
CF.sub.3), (M-1631, H, F, F, 3-Th, Br), (M-1632, H, F, F, 3-Th,
CH.sub.3), (M-1633, H, F, F, pyrrazol-2-yl, H), (M-1634, H, F, F,
pyrrazol-2-yl, Cl), (M-1635, H, F, F, pyrrazol-2-yl, F), (M-1636,
H, F, F, pyrrazol-2-yl, CF.sub.3), (M-1637, H, F, F, pyrrazol-2-yl,
Br), (M-1638, H, F, F, pyrrazol-2-yl, CH.sub.3), (M-1639, H, F, F,
pyrrazol-3-yl, H), (M-1640, H, F, F, pyrrazol-3-yl, Cl), (M-1641,
H, F, F, pyrrazol-3-yl, F), (M-1642, H, F, F, pyrrazol-3-yl,
CF.sub.3), (M-1643, H, F, F, pyrrazol-3-yl, Br), (M-1644, H, F, F,
pyrrazol-3-yl, CH.sub.3), (M-1645, H, F, F, pyrimidin-2-yl, H),
(M-1646, H, F, F, pyrimidin-2-yl, Cl), (M-1647, H, F, F,
pyrimidin-2-yl, F), (M-1648, H, F, F, pyrimidin-2-yl, CF.sub.3),
(M-1649, H, F, F, pyrimidin-2-yl, Br), (M-1650, H, F, F,
pyrimidin-2-yl, CH.sub.3), (M-1651, H, F, F, pyrimidin-4-yl, H),
(M-1652, H, F, F, pyrimidin-4-yl, Cl), (M-1653, H, F, F,
pyrimidin-4-yl, F), (M-1654, H, F, F, pyrimidin-4-yl, CF.sub.3),
(M-1655, H, F, F, pyrimidin-4-yl, Br), (M-1656, H, F, F,
pyrimidin-4-yl, CH.sub.3), (M-1657, H, F, F, pyrimidin-5-yl, H),
(M-1658, H, F, F, pyrimidin-5-yl, Cl), (M-1659, H, F, F,
pyrimidin-5-yl, F), (M-1660, H, F, F, pyrimidin-5-yl, CF.sub.3),
(M-1661, H, F, F, pyrimidin-5-yl, Br), (M-1662, H, F, F,
pyrimidin-5-yl, CH.sub.3), (M-1663, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-1664, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-1665, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-1666, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1667, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-1668, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-1669, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-1670, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-1671, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1672, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1673, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-1674, H, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-1675, H, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-1676, H, F,
F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-1677, H,
F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1678,
H, F, F, (Me).sub.3NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-1679, H, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-1680, H, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-1681,
H, F, F, (Me).sub.3NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-1682, H, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-1683, H, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1684,
H, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-1685, H, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-1686, H, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.3),
(M-1687, H, F, F, MeOCH.sub.2, H), (M-1688, H, F, F, MeOCH.sub.2,
Cl), (M-1689, H, F, F, MeOCH.sub.2, F), (M-1690, H, F, F,
MeOCH.sub.2, CF.sub.3), (M-1691, H, F, F, MeOCH.sub.2, Br),
(M-1692, H, F, F, MeOCH.sub.2, CH.sub.3), (M-1693, H, F, F,
EtOCH.sub.2, H), (M-1694, H, F, F, EtOCH.sub.2, Cl), (M-1695, H, F,
F, EtOCH.sub.2, F), (M-1696, H, F, F, EtOCH.sub.2, CF.sub.3),
(M-1697, H, F, F, EtOCH.sub.2, Br), (M-1698, H, F, F, EtOCH.sub.2,
CH.sub.3), (M-1699, H, F, F, EtOCH.sub.2CH.sub.2, H), (M-1700, H,
F, F, EtOCH.sub.2CH.sub.2, Cl), (M-1701, H, F, F,
EtOCH.sub.2CH.sub.2, F), (M-1702, H, F, F, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-1703, H, F, F, EtOCH.sub.2CH.sub.2, Br), (M-1704, H,
F, F, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-1705, H, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-1706, H, F, F,
MeOCH.sub.2--CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-1707, H, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-1708, H, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-1709, H, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-1710, H, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-1711, H, F, F,
MeOCH.sub.2CH.sub.2, H), (M-1712, H, F, F, MeOCH.sub.2CH.sub.2,
Cl), (M-1713, H, F, F, MeOCH.sub.2CH.sub.2, F), (M-1714, H, F, F,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-1715, H, F, F,
MeOCH.sub.2CH.sub.2, Br), (M-1716, H, F, F, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-1717, H, F, F, HOCH.sub.2, H), (M-1718, H, F, F,
HOCH.sub.2, Cl), (M-1719, H, F, F, HOCH.sub.2, F), (M-1720, H, F,
F, HOCH.sub.2, CF.sub.3), (M-1721, H, F, F, HOCH.sub.2, Br),
(M-1722, H, F, F, HOCH.sub.2, CH.sub.3), (M-1723, H, F, F,
HOCH.sub.1CH.sub.2, H), (M-1724, H, F, F, HOCH.sub.2CH.sub.2, Cl),
(M-1725, H, F, F, HOCH.sub.2CH.sub.2, F), (M-1726, H, F, F,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-1727, H, F, F,
HOCH.sub.2CH.sub.2, Br), (M-1728, H, F, F, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-1729, H, F, F, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-1730, H, F, F, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-1731, H, F,
F, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-1732, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1733, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-1734, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-1735, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-1736, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-1737, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1738, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1739, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-1740, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-1741, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-1742, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-1743, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-1744, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-1745, H,
F, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-1746, H, F,
F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-1747,
H, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-1748, H, F, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-1749, H, F, F,
HOCH.sub.2CH.sub.3OCH.sub.2CH.sub.2, F), (M-1750, H, F, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-1751, H, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-1752, H, F, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-1753, H, F, F,
(Me).sub.2N, H), (M-1754, H, F, F, (Me).sub.2N, Cl), (M-1755, H, F,
F, (Me).sub.2N, F), (M-1756, H, F, F, (Me).sub.2N, CF.sub.3),
(M-1757, H, F, F, (Me).sub.2N, Br), (M-1758, H, F, F, (Me).sub.2N,
CH.sub.2) (M-1759, H, F, F, piperidin-4-yl-methyl, H), (M-1760, H,
F, F, piperidin-4-yl-methyl, Cl), (M-1761, H, F, F,
piperidin-4-yl-methyl, F), (M-1762, H, F, F, piperidin-4-yl-methyl,
CF.sub.3), (M-1763, H, F, F, piperidin-4-yl-methyl, Br), (M-1764,
H, F, F, piperidin-4-yl-methyl, CH.sub.3), (M-1765, H, F, F,
cyclohexylmethyl, H), (M-1766, H, F, F, cyclohexylmethyl, Cl),
(M-1767, H, F, F, cyclohexylmethyl, F), (M-1768, H, F, F,
cyclohexylmethyl, CF.sub.3), (M-1769, H, F, F, cyclohexylmethyl,
Br), (M-1770, H, F, F, cyclohexylmethyl, CH.sub.3), (M-1771, H, F,
Cl, H, H), (M-1772, H, F, Cl, H, Cl), (M-1773, H, F, Cl, H, F),
(M-1774, H, F, Cl, H, CF.sub.3), (M-1775, H, F, Cl, H, Br),
(M-1776, H, F, Cl, H, CH.sub.3), (M-1777, H, F, Cl, F, H), (M-1778,
H, F, Cl, F, Cl), (M-1779, H, F, Cl, F, F), (M-1780, H, F, Cl, F,
CF.sub.3), (M-1781, H, F, Cl, F, Br), (M-1782, H, F, Cl, F,
CH.sub.3), (M-1783, H, F, Cl, Cl, H), (M-1784, H, F, Cl, Cl, Cl),
(M-1785, H, F, Cl, Cl, F), (M-1786, H, F, Cl, Cl, CF.sub.3),
(M-1787, H, F, Cl, Cl, Br), (M-1788, H, F, Cl, Cl, CH.sub.3),
(M-1789, H, F, Cl, CH.sub.3, H), (M-1790, H, F, Cl, CH.sub.3, Cl),
(M-1791, H, F, Cl, CH.sub.3, F), (M-1792, H, F, Cl, CH.sub.3,
CF.sub.3), (M-1793, H, F, Cl, CH.sub.3, Br), (M-1794, H, F, Cl,
CH.sub.3, CH.sub.3), (M-1795, H, F, Cl, Et, H), (M-1796, H, F, Cl,
Et, Cl), (M-1797, H, F, Cl, Et, F), (M-1798, H, F, Cl, Et,
CF.sub.3), (M-1799, H, F, Cl, Et, Br), (M-1800, H, F, Cl, Et,
CH.sub.3), (M-1801, H, F, Cl, n-Pr, H), (M-1802, H, F, Cl, n-Pr,
Cl), (M-1803, H, F, Cl, n-Pr, F), (M-1804, H, F, Cl, n-Pr,
CF.sub.3), (M-1805, H, F, Cl, n-Pr, Br), (M-1806, H, F, Cl, n-Pr,
CH.sub.3), (M-1807, H, F, Cl, c-Pr, H), (M-1808, H, F, Cl, c-Pr,
Cl), (M-1809, H, F, Cl, c-Pr, F), (M-1810, H, F, Cl, c-Pr,
CF.sub.3), (M-1811, H, F, Cl, c-Pr, Br), (M-1812, H, F, Cl, c-Pr,
CF.sub.3), (M-1813, H, F, Cl, i-Pr, H), (M-1814, H, F, Cl, i-Pr,
Cl), (M-1815, H, F, Cl, i-Pr, F), (M-1816, H, F, Cl, i-Pr,
CF.sub.3), (M-1817, H, F, Cl, i-Pr, Br), (M-1818, H, F, Cl, i-Pr,
CH.sub.3), (M-1819, H, F, Cl, n-Bu, H), (M-1820, H, F, Cl, n-Bu,
Cl), (M-1821, H, F, Cl, n-Bu, F), (M-1822, H, F, Cl, n-Bu,
CF.sub.3), (M-1823, H, F, Cl, n-Bu, Br), (M-1824, H, F, Cl, n-Bu,
CH.sub.3), (M-1825, H, F, Cl, i-Bu, H), (M-1826, H, F, Cl, i-Bu,
Cl), (M-1827, H, F, Cl, i-Bu, F), (M-1828, H, F, Cl, i-Bu,
CF.sub.3), (M-1829, H, F, Cl, i-Bu, Br), (M-1830, H, F, Cl, i-Bu,
CH.sub.3), (M-1831, H, F, Cl, sec-Bu, H), (M-1832, H, F, Cl,
sec-Bu, Cl), (M-1833, H, F, Cl, sec-Bu, F), (M-1834, H, F, Cl,
sec-Bu, CF.sub.3), (M-1835, H, F, Cl, sec-Bu, Br), (M-1836, H, F,
Cl, sec-Bu, CH.sub.3), (M-1837, H, F, Cl, n-Pen, H), (M-1838, H, F,
Cl, n-Pen, Cl), (M-1839, H, F, Cl, n-Pen, F), (M-1840, H, F, Cl,
n-Pen, CF.sub.3), (M-1841, H, F, Cl, n-Pen, Br), (M-1842, H, F, Cl,
n-Pen, CH.sub.3), (M-1843, H, F, Cl, c-Pen, H), (M-1844, H, F, Cl,
c-Pen, Cl), (M-1845, H, F, Cl, c-Pen, F), (M-1846, H, F, Cl, c-Pen,
CF.sub.3), (M-1847, H, F, Cl, c-Pen, Br), (M-1848, H, F, Cl, c-Pen,
CH.sub.3), (M-1849, H, F, Cl, n-Hex, H), (M-1850, H, F, Cl, n-Hex,
Cl), (M-1851, H, F, Cl, n-Hex, F), (M-1852, H, F, Cl, n-Hex,
CF.sub.3), (M-1853, H, F, Cl, n-Hex, Br), (M-1854, H, F, Cl, n-Hex,
CH.sub.3), (M-1855, H, F, Cl, c-Hex, H), (M-1856, H, F, Cl, c-Hex,
Cl), (M-1857, H, F, Cl, c-Hex, F), (M-1858, H, F, Cl, c-Hex,
CF.sub.3), (M-1859, H, F, Cl, c-Hex, Br), (M-1860, H, F, Cl, c-Hex,
CH.sub.3), (M-1861, H, F, Cl, OH, H), (M-1862, H, F, Cl, OH, Cl),
(M-1863, H, F, Cl, OH, F), (M-1864, H, F, Cl, OH, CF.sub.3),
(M-1865, H, F, Cl, OH, Br), (M-1866, H, F, Cl, OH, CH.sub.3),
(M-1867, H, F, Cl, EtO, H), (M-1868, H, F, Cl, EtO, Cl), (M-1869,
H, F, Cl, EtO, F), (M-1870, H, F, Cl, EtO, CF.sub.3), (M-1871, H,
F, Cl, EtO, Br), (M-1872, H, F, Cl, EtO, CH.sub.3), (M-1873, H, F,
Cl, n-PrO, H), (M-1874, H, F, Cl, n-PrO, Cl), (M-1875, H, F, Cl,
n-PrO, F), (M-1876, H, F, Cl, n-PrO, CF.sub.3), (M-1877, H, F, Cl,
n-PrO, Br), (M-1878, H, F, Cl, n-PrO, CH.sub.3), (M-1879, H, F, Cl,
PhO, H), (M-1880, H, F, Cl, PhO, Cl), (M-1881, H, F, Cl, PhO, F),
(M-1882, H, F, Cl, PhO, CF.sub.3), (M-1883, H, F, Cl, PhO, Br),
(M-1884, H, F, Cl, PhO, CH.sub.3), (M-1885, H, F, Cl, BnO, H),
(M-1886, H, F, Cl, BnO, Cl), (M-1887, H, F, Cl, BnO, F), (M-1888,
H, F, Cl, BnO, CF.sub.3), (M-1889, H, F, Cl, BnO, Br), (M-1890, H,
F, Cl, BnO, CH.sub.3), (M-1891, H, F, Cl, PhCH.sub.2CH.sub.2O, H),
(M-1892, H, F, Cl, PhCH.sub.2CH.sub.2O, Cl), (M-1893, H, F, Cl,
PhCH.sub.2CH.sub.2O, F), (M-1894, H, F, Cl, PhCH.sub.2CH.sub.2O,
CF.sub.3), (M-1895, H, F, Cl, PhCH.sub.2CH.sub.2O, Br), (M-1896, H,
F, Cl, PhCH.sub.2CH.sub.2O, CH.sub.3), (M-1897, H, F, Cl,
CF.sub.3O, H), (M-1898, H, F, Cl, CF.sub.3O, Cl), (M-1899, H, F,
Cl, CF.sub.3O, F), (M-1900, H, F, Cl, CF.sub.3O, CF.sub.3),
(M-1901, H, F, Cl, CF.sub.3O, Br), (M-1902, H, F Cl, CF.sub.3O,
CH.sub.3), (M-1903, H, F, Cl, Ph, H), (M-1904, H, F, Cl, Ph, Cl),
(M-1905, H, F, Cl, Ph, F), (M-1906, H, F, Cl, Ph, CF.sub.3),
(M-1907, H, F, Cl, Ph, Br), (M-1908, H, F, Cl, Ph, CH.sub.3),
(M-1909, H, F, Cl, 4-F-Ph, H), (M-1910, H, F, Cl, 4-F-Ph, Cl),
(M-1911, H, F, Cl, 4-F-Ph, F), (M-1912, H, F, Cl, 4-F-Ph,
CF.sub.3), (M-1913, H, F, Cl, 4-F-Ph, Br), (M-1914, H, F, Cl,
4-F-Ph, CH.sub.3), (M-1915, H, F, Cl, 4-CF.sub.3-Ph, H), (M-1916,
H, F, Cl, 4-CF.sub.3-Ph, Cl), (M-1917, H, F, Cl, 4-CF.sub.3-Ph, F),
(M-1918, H, F, Cl, 4-CF.sub.3-Ph, CF.sub.3), (M-1919, H, F, Cl,
4-CF.sub.3-Ph, Br), (M-1920, H, F, Cl, 4-CF.sub.3-Ph, CH.sub.3),
(M-1921, H, F, Cl, 4-(Me).sub.2N-Ph, H), (M-1922, H, F, Cl,
4-(Me).sub.2N-Ph, Cl), (M-1923, H, F, Cl, 4-(Me).sub.2N-Ph, F),
(M-1924, H, F, Cl, 4-(Me).sub.2N-Ph, CF.sub.3), (M-1925, H, F, Cl,
4-(Me).sub.2N-Ph, Br), (M-1926, H, F, Cl, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-1927, H, F, Cl, 4-OH-Ph, H), (M-1928, H, F, Cl,
4-OH-Ph, Cl), (M-1929, H, F, Cl, 4-OH-Ph, F), (M-1930, H, F, Cl,
4-OH-Ph, CF.sub.3), (M-1931, H, F, Cl, 4-OH-Ph, Br), (M-1932, H, F,
Cl, 4-OH-Ph, CH.sub.3), (M-1933, H, F, Cl, 3,4-di-F-Ph, H),
(M-1934, H, F, Cl, 3,4-di-F-Ph, Cl), (M-1935, H, F, Cl,
3,4-di-F-Ph, F), (M-1936, H, F, Cl, 3,4-di-F-Ph, CF.sub.3),
(M-1937, H, F, Cl, 3,4-di-F-Ph, Br), (M-1938, H, F, Cl,
3,4-di-F-Ph, CH.sub.3), (M-1939, H, F, Cl, 4-COOH-Ph, H), (M-1940,
H, F, Cl, 4-COOH-Ph, Cl), (M-1941, H, F, Cl, 4-COOH-Ph, F),
(M-1942, H, F, Cl, 4-COOH-Ph, CF.sub.3), (M-1943, H, F, Cl,
4-COOH-Ph, Br), (M-1944, H, F, Cl, 4-COOH-Ph, CH.sub.3), (M-1945,
H, F, Cl, Bn, H), (M-1946, H, F, Cl, Bn, Cl), (M-1947, H, F, Cl,
Bn, F), (M-1948, H, F, Cl, Bn, CF.sub.3), (M-1949, H, F, Cl, Bn,
Br), (M-1950, H, F, Cl, Bn, CH.sub.3), (M-1951, H, F, Cl, 4-F-Bn,
H), (M-1952, H, F, Cl, 4-F-Bn, Cl), (M-1953, H, F, Cl, 4-F-Bn, F),
(M-1954, H, F, Cl, 4-F-Bn, CF.sub.3), (M-1955, H, F, Cl, 4-F-Bn,
Br), (M-1956, H, F, Cl, 4-F-Bn, CH.sub.3), (M-1957, H, F, Cl, 2-Py,
H), (M-1958, H, F, Cl, 2-Py, Cl), (M-1959, H, F, Cl, 2-Py, F),
(M-1960, H, F, Cl, 2-Py, CF.sub.3), (M-1961, H, F, Cl, 2-Py, Br),
(M-1962, H, F, Cl, 2-Py, CH.sub.3), (M-1963, H, F, Cl, 3-Py, H),
(M-1964, H, F, Cl, 3-Py, Cl), (M-1965, H, F, Cl, 3-Py, F), (M-1966,
H, F, Cl, 3-Py, CF.sub.3), (M-1967, H, F, Cl, 3-Py, Br), (M-1968,
H, F, Cl, 3-Py, CH.sub.3
), (M-1969, H, F, Cl, 4-Py, H), (M-1970, H, F, Cl, 4-Py, Cl),
(M-1971, H, F, Cl, 4-Py, F), (M-1972, H, F, Cl, 4-Py, CF.sub.3),
(M-1973, H, F, Cl, 4-Py, Br), (M-1974, H, F, Cl, 4-Py, CH.sub.3),
(M-1975, H, F, Cl, 2-Th, H), (M-1976, H, F, Cl, 2-Th, Cl), (M-1977,
H, F, Cl, 2-Th, F), (M-1978, H, F, Cl, 2-Th, CF.sub.3), (M-1979, H,
F, Cl, 2-Th, Br), (M-1980, H, F, Cl, 2-Th, CH.sub.3), (M-1981, H,
F, Cl, 3-Th, H), (M-1982, H, F, Cl, 3-Th, Cl), (M-1983, H, F, Cl,
3-Th, F), (M-1984, H, F, Cl, 3-Th, CF.sub.3), (M-1985, H, F, Cl,
3-Th, Br), (M-1986, H, F, Cl, 3-Th, CH.sub.3), (M-1987, H, F, Cl,
pyrrazol-2-yl, H), (M-1988, H, F, Cl, pyrrazol-2-yl, Cl), (M-1989,
H, F, Cl, pyrrazol-2-yl, F), (M-1990, H, F, Cl, pyrrazol-2-yl,
CF.sub.3), (M-1991, H, F, Cl, pyrrazol-2-yl, Br), (M-1992, H, F,
Cl, pyrrazol-2-yl, CH.sub.3), (M-1993, H, F, Cl, pyrrazol-3-yl, H),
(M-1994, H, F, Cl, pyrrazol-3-yl, Cl), (M-1995, H, F, Cl,
pyrrazol-3-yl, F), (M-1996, H, F, Cl, pyrrazol-3-yl, CF.sub.3),
(M-1997, H, F, Cl, pyrrazol-3-yl, Br), (M-1998, H, F, Cl,
pyrrazol-3-yl, CH.sub.3), (M-1999, H, F, Cl, pyrimidin-2-yl, H),
(M-2000, H, F, Cl, pyrimidin-2-yl, Cl), (M-2001, H, F, Cl,
pyrimidin-2-yl, F), (M-2002, H, F, Cl, pyrimidin-2-yl, CF.sub.3),
(M-2003, H, F, Cl, pyrimidin-2-yl, Br), (M-2004, H, F, Cl,
pyrimidin-2-yl, CH.sub.3), (M-2005, H, F, Cl, pyrimidin-4-yl, H),
(M-2006, H, F, Cl, pyrimidin-4-yl, Cl), (M-2007, H, F, Cl,
pyrimidin-4-yl, F), (M-2008, H, F, Cl, pyrimidin-4-yl, CF.sub.3),
(M-2009, H, F, Cl, pyrimidin-4-yl, Br), (M-2010, H, F, Cl,
pyrimidin-4-yl, CH.sub.3), (M-2011, H, F, Cl, pyrimidin-5-yl, H),
(M-2012, H, F, Cl, pyrimidin-5-yl, Cl), (M-2013, H, F, Cl,
pyrimidin-5-yl, F), (M-2014, H, F, Cl, pyrimidin-5-yl, CF.sub.3),
(M-2015, H, F, Cl, pyrimidin-5-yl, Br), (M-2016, H, F, Cl,
pyrimidin-5-yl, CH.sub.3), (M-2017, H, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-2018, H, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-2019, H, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-2020, H, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2021, H, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-2022, H, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-2023, H, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2024, H, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-2025, H, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2026, H, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2027, H, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-2028, H, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-2029, H, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2030, H, F,
Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-2031, H,
F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2032,
H, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-2033, H, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-2034, H, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-2035,
H, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H),
(M-2036, H, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-2037, H, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2038,
H, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-2039, H, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-2040, H, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3),
(M-2041, H, F, Cl, MeOCH.sub.2, H), (M-2042, H, F, Cl, MeOCH.sub.2,
Cl), (M-2043, H, F, Cl, MeOCH.sub.2, F), (M-2044, H, F, Cl,
MeOCH.sub.2, CF.sub.3), (M-2045, H, F, Cl, MeOCH.sub.2, Br),
(M-2046, H, F, Cl, MeOCH.sub.2, CH.sub.3), (M-2047, H, F, Cl,
EtOCH.sub.2, H), (M-2048, H, F, Cl, EtOCH.sub.2, Cl), (M-2049, H,
F, Cl, EtOCH.sub.2, F), (M-2050, H, F, Cl, EtOCH.sub.2, CF.sub.3),
(M-2051, H, F, Cl, EtOCH.sub.2, Br), (M-2052, H, F, Cl,
EtOCH.sub.2, CH.sub.3), (M-2053, H, F, Cl, EtOCH.sub.2CH.sub.2, H),
(M-2054, H, F, Cl, EtOCH.sub.2CH.sub.2, Cl), (M-2055, H, F, Cl,
EtOCH.sub.2CH.sub.2, F), (M-2056, H, F, Cl, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-2057, H, F, Cl, EtOCH.sub.2CH.sub.2, Br), (M-2058, H,
F, Cl, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-2059, H, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-2060, H, F, Cl,
MeOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-2061, H, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-2062, H, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-2063, H, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-2064, H, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-2065, H, F, Cl,
MeOCH.sub.2CH.sub.2, H), (M-2066, H, F, Cl, MeOCH.sub.2CH.sub.2,
Cl), (M-2067, H, F, Cl, MeOCH.sub.2CH.sub.2, F), (M-2068, H, F, Cl,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-2069, H, F, Cl,
MeOCH.sub.2CH.sub.2, Br), (M-2070, H, F, Cl, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-2071, H, F, Cl, HOCH.sub.2, H), (M-2072, H, F, Cl,
HOCH.sub.2, Cl), (M-2073, H, F, Cl, HOCH.sub.2, F), (M-2074, H, F,
Cl, HOCH.sub.2, CF.sub.3), (M-2075, H, F, Cl, HOCH.sub.2, Br),
(M-2076, H, F, Cl, HOCH.sub.2, CH.sub.3), (M-2077, H, F, Cl,
HOCH.sub.2CH.sub.2, H), (M-2078, H, F, Cl, HOCH.sub.2CH.sub.2, Cl),
(M-2079, H, F, Cl, HOCH.sub.2CH.sub.2, F), (M-2080, H, F, Cl,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-2081, H, F, Cl,
HOCH.sub.2CH.sub.2, Br), (M-2082, H, F, Cl, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-2083, H, F, Cl, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-2084, H, F, Cl, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-2085, H, F,
Cl, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-2086, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2087, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-2088, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-2089, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2090, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-2091, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2092, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2093, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-2094, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-2095, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-2096, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-2097, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2098, H, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-2099, H, F,
Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-2100, H, F,
Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-2101,
H, F, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-2102, H, F,
Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-2103, H, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-2104, H, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-2105, H, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-2106, H, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-2107, H, F, Cl,
(Me).sub.2N, H), (M-2108, H, F, Cl, (Me).sub.2N, Cl), (M-2109, H,
F, Cl, (Me).sub.2N, F), (M-2110, H, F, Cl, (Me).sub.2N, CF.sub.3),
(M-2111, H, F, Cl, (Me).sub.2N, Br), (M-2112, H, F, Cl,
(Me).sub.2N, CH.sub.3), (M-2113, H, F, Cl, piperidin-4-yl-methyl,
H), (M-2114, H, F, Cl, piperidin-4-yl-methyl, Cl), (M-2115, H, F,
Cl, piperidin-4-yl-methyl, F), (M-2116, H, F, Cl,
piperidin-4-yl-methyl, CF.sub.3), (M-2117, H, F, Cl,
piperidin-4-yl-methyl, Br), (M-2118, H, F, Cl, piperidin,
4-yl-methyl, CH.sub.3), (M-2119, H, F, Cl, cyclohexylmethyl, H),
(M-2120, H, F, Cl, cyclohexylmethyl, Cl), (M-2121, H, F, Cl,
cyclohexylmethyl, F), (M-2122, H, F, Cl, cyclohexylmethyl,
CF.sub.3), (M-2123, H, F, Cl, cyclohexylmethyl, Br), (M-2124, H, F,
Cl, cyclohexylmethyl, CH.sub.3), (M-2125, H, CH.sub.3, H, H, H),
(M-2126, H, CH.sub.3, H, H, Cl), (M-2127, H, CH.sub.3, H, H, F),
(M-2128, H, CH.sub.3, H, H, CF.sub.3), (M-2129, H, CH.sub.3, H, H,
Br), (M-2130, H, CH.sub.3, H, H, CH.sub.3), (M-2131, H, CH.sub.3,
H, F, H), (M-2132, H, CH.sub.3, H, F, Cl), (M-2133, H, CH.sub.3, H,
F, F), (M-2134, H, CH.sub.3, H, F, CF.sub.3), (M-2135, H, CH.sub.3,
H, F, Br), (M-2136, H, CH.sub.3, H, F, CH.sub.3), (M-2137, H,
CH.sub.3, H, Cl, H), (M-2138, H, CH.sub.3, H, Cl, Cl), (M-2139, H,
CH.sub.3, H, Cl, F), (M-2140, H, CH.sub.3, H, Cl, CF.sub.3),
(M-2141, H, CH.sub.3, H, Cl, Br), (M-2142, H, CH.sub.3, H, Cl,
CH.sub.3), (M-2143, H, CH.sub.3, H, CH.sub.3, H), (M-2144, H,
CH.sub.3, H, CH.sub.3, Cl), (M-2145, H, CH.sub.3, H, CH.sub.3, F),
(M-2146, H, CH.sub.3, H, CH.sub.3, CF.sub.3), (M-2147, H, CH.sub.3,
H, CH.sub.3, Br), (M-2148, H, CH.sub.3, H, CH.sub.3, CH.sub.3),
(M-2149, H, CH.sub.3, H, Et, H), (M-2150, H, CH.sub.3, H, Et, Cl),
(M-2151, H, CH.sub.3, H, Et, F), (M-2152, H, CH.sub.3, H, Et,
CF.sub.3), (M-2153, H, CH.sub.3, H, Et, Br), (M-2154, H, CH.sub.3,
H, Et, CH.sub.3), (M-2155, H, CH.sub.3, H, n-Pr, H), (M-2156, H,
CH.sub.3, H, n-Pr, Cl), (M-2357, H, CH.sub.3, H, n-Pr, F), (M-2158,
H, CH.sub.3, H, n-Pr, CF.sub.3), (M-2159, H, CH.sub.3, H, n-Pr,
Br), (M-2160, H, CH.sub.3, H, n-Pr, CH.sub.3), (M-2161, H,
CH.sub.3, H, c-Pr, H), (M-2162, H, CH.sub.3, H, c-Pr, Cl), (M-2163,
H, CH.sub.3, H, c-Pr, F), (M-2164, H, CH.sub.3, H, c-Pr, CF.sub.3),
(M-2165, H, CH.sub.3, H, c-Pr, Br), (M-2166, H, CH.sub.3, H, c-Pr,
CH.sub.3), (M-2167, H, CH.sub.3, H, i-Pr, H), (M-2168, H, CH.sub.3,
H, i-Pr, Cl), (M-2169, H, CH.sub.3, H, i-Pr, F), (M-2170, H,
CH.sub.3, H, i-Pr, CF.sub.3), (M-2171, H, CH.sub.3, H, i-Pr, Br),
(M-2172, H, CH.sub.3, H, i-Pr, CH.sub.3), (M-2173, H, CH.sub.3, H,
n-Bu, H), (M-2174, H, CH.sub.3, H, n-Bu, Cl), (M-2175, H, CH.sub.3,
H, n-Bu, F), (M-2176, H, CH.sub.3, H, n-Bu, CF.sub.3), (M-2177, H,
CH.sub.3, H, n-Bu, Br), (M-2178, H, CH.sub.3, H, n-Bu, CH.sub.3),
(M-2179, H, CH.sub.3H, i-Bu, H), (M-2180, H, CH.sub.3, H, i-Bu,
Cl), (M-2181, H, CH.sub.3, H, i-Bu, F), (M-2182, H, CH.sub.3, H,
i-Bu, CF.sub.3), (M-2183, H, CH.sub.3, H, i-Bu, Br), (M-2184, H,
CH.sub.3, H, i-Bu, CH.sub.3), (M-2185, H, CH.sub.3, H, sec-Bu, H),
(M-2186, H, CH.sub.3, H, sec-Bu, Cl), (M-2187, H, CH.sub.3, H,
sec-Bu, F), (M-2188, H, CH.sub.3, H, sec-Bu, CF.sub.3), (M-2189, H,
CH.sub.3, H, sec-Bu, Br), (M-2190, H, CH.sub.3, H, sec-Bu,
CH.sub.3), (M-2191, H, CH.sub.3, H, n-Pen, H), (M-2192, H,
CH.sub.3, H, n-Pen, Cl), (M-2193, H, CH.sub.3, H, n-Pen, F),
(M-2194, H, CH.sub.3, H, n-Pen, CF.sub.3), (M-2195, H, CH.sub.3, H,
n-Pen, Br), (M-2196, H, CH.sub.3, H, n-Pen, CH.sub.3), (M-2197, H,
CH.sub.2, H, c-Pen, H), (M-2198, H, CH.sub.3, H, c-Pen, Cl),
(M-2199, H, CH.sub.3, H, c-Pen, F), (M-2200, H, CH.sub.3, H, c-Pen,
CF.sub.3), (M-2201, H, CH.sub.3, H, c-Pen, Br), (M-2202, H,
CH.sub.3, H, c-Pen, CH.sub.3), (M-2203, H, CH.sub.3, H, n-Hex, H),
(M-2204, H, CH.sub.3, H, n-Hex, Cl), (M-2205, H, CH.sub.3, H,
n-Hex, F), (M-2206, H, CH.sub.3, H, n-Hex, CF.sub.3), (M-2207, H,
CH.sub.3, H, n-Hex, Br), (M-2208, H, CH.sub.3, H, n-Hex, CH.sub.3),
(M-2209, H, CH.sub.3, H, c-Hex, H), (M-2210, H, CH.sub.3, H, c-Hex,
Cl), (M-2211, H, CH.sub.3, H, c-Hex, F), (M-2212, H, CH.sub.3, H,
c-Hex, CF.sub.3), (M-2213, H, CH.sub.3, H, c-Hex, Br), (M-2214, H,
CH.sub.3, H, c-Hex, CH.sub.3), (M-2215, H, CH.sub.3, H, OH, H),
(M-2216, H, CH.sub.3, H, OH, Cl), (M-2217, H, CH.sub.3, H, OH, F),
(M-2218, H, CH.sub.3, H, OH, CF.sub.3), (M-2219, H, CH.sub.3, H,
OH, Br), (M-2220, H, CH.sub.3, H, OH, CH.sub.3), (M-2221, H,
CH.sub.3, H, EtO, H), (M-2222, H, CH.sub.3, H, EtO, Cl), (M-2223,
H, CH.sub.3, H, EtO, F), (M-2224, H, CH.sub.3, H, EtO, CF.sub.3),
(M-2225, H, CH.sub.3, H, EtO, Br), (M-2226, H, CH.sub.3, H, EtO,
CH.sub.3), (M-2227, H, CH.sub.3, H, n-PrO, H), (M-2228, H,
CH.sub.3, H, n-PrO, Cl), (M-2229, H, CH.sub.3, H, n-PrO, F),
(M-2230, H, CH.sub.3, H, n-PrO, CF.sub.3), (M-2231, H, CH.sub.3, H,
n-PrO, Br), (M-2232, H, CH.sub.3, H, n-PrO, CH.sub.3), (M-2233, H,
CH.sub.3, H, PhO, H), (M-2234, H, CH.sub.3, H, PhO, Cl), (M-2235,
H, CH.sub.3, H, PhO, F), (M-2236, H, CH.sub.3, H, PhO, CF.sub.3),
(M-2237, H, CH.sub.3, H, PhO, Br), (M-2238, H, CH.sub.3, H, PhO,
CH.sub.3), (M-2239, H, CH.sub.3, H, BnO, H), (M-2240, H, CH.sub.3,
H, BnO, Cl), (M-2241, H, CH.sub.3, H, BnO, F), (M-2242, H,
CH.sub.3, H, BnO, CF.sub.3), (M-2243, H, CH.sub.3, H, BnO, Br),
(M-2244, H, CH.sub.3, H, BnO, CH.sub.3), (M-2245, H, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, H), (M-2246, H, CH.sub.3, H,
PhCH.sub.2CH.sub.30, Cl), (M-2247, H, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, F), (M-2248, H, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-2249, H, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, Br), (M-2250, H, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-2251, H, CH.sub.3, H, CF.sub.3O,
H), (M-2252, H, CH.sub.3, H, CF.sub.3O, Cl), (M-2253, H, CH.sub.3,
H, CF.sub.3O, F), (M-2254, H, CH.sub.3, H, CF.sub.3O, CF.sub.3),
(M-2255, H, CH.sub.3, H, CF.sub.3O, Br), (M-2256, H, CH.sub.3, H,
CF.sub.3O, CH.sub.3), (M-2257, H, CH.sub.3, H, Ph, H), (M-2258, H,
CH.sub.3, H, Ph, Cl), (M-2259, H, CH.sub.3, H, Ph, F), (M-2260, H,
CH.sub.3, H, Ph, CF.sub.3), (M-2261, H, CH.sub.3, H, Ph, Br),
(M-2262, H, CH.sub.3, H, Ph, CH.sub.3), (M-2263, H, CH.sub.3, H,
4-F-Ph, H), (M-2264, H, CH.sub.3, H, 4-F-Ph, Cl), (M-2265, H,
CH.sub.3(H, 4-F-Ph, F), (M-2266, H, CH.sub.3, H, 4-F-Ph, CF.sub.3),
(M-2267, H, CH.sub.3, H, 4-F-Ph, Br), (M-2268, H, CH.sub.3, H,
4-F-Ph, CH.sub.3), (M-2269, H, CH.sub.3, H, 4-CF.sub.3-Ph, H),
(M-2270, H, CH.sub.3, H, 4-CF.sub.3-Ph, Cl), (M-2271, H, CH.sub.3,
H, 4-CF.sub.3-Ph, F), (M-2272, H, CH.sub.3, H, 4-CF.sub.3-Ph,
CF.sub.3), (M-2273, H, CH.sub.3, H, 4-CF.sub.3-Ph, Br), (M-2274, H,
CH.sub.3, H, 4-CF.sub.3-Ph, CH.sub.3), (M-2275, H, CH.sub.3, H,
4-(Me).sub.2N-Ph, H), (M-2276, H, CH.sub.3, H, 4-(Me).sub.2N-Ph,
Cl), (M-2277, H, CH.sub.3, H, 4-(Me).sub.2N-Ph, F), (M-2278, H,
CH.sub.3, H, 4-(Me).sub.2N-Ph, CF.sub.3), (M-2279, H, CH.sub.3, H,
4-(Me).sub.2N-Ph, Br), (M-2280, H, CH.sub.3, H, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-2281, H, CH.sub.3, H, 4-OH-Ph, H), (M-2282, H,
CH.sub.3, H, 4-OH-Ph, Cl), (M-2283, H, CH.sub.3, H, 4-OH-Ph, F),
(M-2284, H, CH.sub.3, H, 4-OH-Ph, CF.sub.3), (M-2285, H, CH.sub.3,
H, 4-OH-Ph, Br), (M-2286, H, CH.sub.3, H, 4-OH-Ph, CH.sub.3),
(M-2287, H, CH.sub.3, H, 3,4-di-F-Ph, H), (M-2288, H, CH.sub.3, H,
3,4-di-F-Ph, Cl), (M-2289, H, CH.sub.3, H, 3,4-di-F-Ph, F),
(M-2290, H, CH.sub.3, H, 3,4-di-F-Ph, CF.sub.3), (M-2291, H,
CH.sub.3, H, 3,4-di-F-Ph, Br), (M-2292, H, CH.sub.3, H,
3,4-di-F-Ph, CH.sub.3), (M-2293, H, CH.sub.3, H, 4-COOH-Ph, H),
(M-2294, H, CH.sub.3, H, 4-COOH-Ph, Cl), (M-2295, H, CH.sub.3, H,
4-COOH-Ph, F), (M-2296, H, CH.sub.3, H, 4-COOH-Ph, CF.sub.3),
(M-2297, H, CH.sub.3, H, 4-COOH-Ph, Br), (M-2298, H, CH.sub.3, H,
4-COOH-Ph, CH.sub.3), (M-2299, H, CH.sub.3, H, Bn, H), (M-2300, H,
CH.sub.3, H, Bn, Cl), (M-2301, H, CH.sub.3, H, Bn, F), (M-2302, H,
CH.sub.3, H, Bn, CF.sub.3), (M-2303, H, CH.sub.3, H, Bn, Br),
(M-2304, H, CH.sub.3, H, Bn, CH.sub.3), (M-2305, H, CH.sub.3, H,
4-F-Bn, H), (M-2306, H, CH.sub.3, H, 4-F-Bn, Cl), (M-2307, H,
CH.sub.3, H, 4-F-Bn, F), (M-2308, H, CH.sub.3, H, 4-F-Bn,
CF.sub.3), (M-2309, H, CH.sub.3, H, 4-F-Bn, Br), (M-2310, H,
CH.sub.3, H, 4-F-Bn, CH.sub.3), (M-2311, H, CH.sub.3, H, 2-Py, H),
(M-2312, H, CH.sub.3, H, 2-Py, Cl), (M-2313, H, CH
.sub.3, H, 2-Py, F), (M-2314, H, CH.sub.3, H, 2-Py, CF.sub.3),
(M-2315, H, CH.sub.3, H, 2-Py, Br), (M-2316, H, CH.sub.3, H, 2-Py,
CH.sub.3), (M-2317, H, CH.sub.3, H, 3-Py, H), (M-2318, H, CH.sub.3,
H, 3-Py, Cl), (M-2319, H, CH.sub.3, H, 3-Py, F), (M-2320, H,
CH.sub.3, H, 3-Py, CF.sub.3), (M-2321, H, CH.sub.3, H, 3-Py, Br),
(M-2322, H, CH.sub.3, H, 3-Py, CH.sub.3), (M-2323, H, CH.sub.3, H,
4-Py, H), (M-2324, H, CH.sub.3, H, 4-Py, Cl), (M-2325, H, CH.sub.3,
H, 4-Py, F), (M-2326, H, CH.sub.3, H, 4-Py, CF.sub.3), (M-2327, H,
CH.sub.3, H, 4-Py, Br), (M-2328, H, CH.sub.3, H, 4-Py, CH.sub.3),
(M-2329, H, CH.sub.3, H, 2-Th, H), (M-2330, H, CH.sub.3, H, 2-Th,
Cl), (M-2331, H, CH.sub.3, H, 2-Th, F), (M-2332, H, CH.sub.3, H,
2-Th, CF.sub.3), (M-2333, H, CH.sub.3, H, 2-Th, Br), (M-2334, H,
CH.sub.3, H, 2-Th, CH.sub.3), (M-2335, H, CH.sub.3, H, 3-Th, H),
(M-2336, H, CH.sub.3, H, 3-Th, Cl), (M-2337, H, CH.sub.3, H, 3-Th,
F), (M-2338, H, CH.sub.3, H, 3-Th, CF.sub.3), (M-2339, H, CH.sub.3,
H, 3-Th, Br), (M-2340, H, CH.sub.3, H, 3-Th, CH.sub.3), (M-2341, H,
CH.sub.3, H, pyrrazol-2-yl, H), (M-2342, H, CH.sub.3, H,
pyrrazol-2-yl, Cl), (M-2343, H, CH.sub.3, H, pyrrazol-2-yl, F),
(M-2344, H, CH.sub.3, H, pyrrazol-2-yl, CF.sub.3), (M-2345, H,
CH.sub.3, H, pyrrazol-2-yl, Br), (M-2346, H, CH.sub.3, H,
pyrrazol-2-yl, CH.sub.3), (M-2347, H, CH.sub.3, H, pyrrazol-3-yl,
H), (M-2348, H, CH.sub.3, H, pyrrazol-3-yl, Cl), (M-2349, H,
CH.sub.3, H, pyrrazol-3-yl, F), (M-2350, H, CH.sub.3, H,
pyrrazol-3-yl, CF.sub.3), (M-2351, H, CH.sub.3, H, pyrrazol-3-yl,
Br), (M-2352, H, CH.sub.3, H, pyrrazol-3-yl, CH.sub.3), (M-2353, H,
CH.sub.3, H, pyrimidin-2-yl, H), (M-2354, H, CH.sub.3, H,
pyrimidin-2-yl, Cl), (M-2355, H, CH.sub.3, H, pyrimidin-2-yl, F),
(M-2356, H, CH.sub.3, H, pyrimidin-2-yl, CF.sub.3), (M-2357, H,
CH.sub.3, H, pyrimidin-2-yl, Br), (M-2358, H, CH.sub.3, H,
pyrimidin-2-yl, CH.sub.3), (M-2359, H, CH.sub.3, H, pyrimidin-4-yl,
H), (M-2360, H, CH.sub.3, H, pyrimidin-4-yl, Cl), (M-2361, H,
CH.sub.3, H, pyrimidin-4-yl, F), (M-2362, H, CH.sub.3, H,
pyrimidin-4-yl, CF.sub.3), (M-2363, H, CH.sub.3, H, pyrimidin-4-yl,
Br), (M-2364, H, CH.sub.3, H, pyrimidin-4-yl, CH.sub.3), (M-2365,
H, CH.sub.3, H, pyrimidin-5-yl, H), (M-2366, H, CH.sub.3, H,
pyrimidin-5-yl, Cl), (M-2367, H, CH.sub.3, H, pyrimidin-5-yl, F),
(M-2368, H, CH.sub.3, H, pyrimidin-5-yl, CF.sub.3), (M-2369, H,
CH.sub.3, H, pyrimidin-5-yl, Br), (M-2370, H, CH.sub.3, H,
pyrimidin-5-yl, CH.sub.3), (M-2371, H, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-2372, H, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-2373, H, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-2374, H, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2375, H, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-2376, H, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-2377, H, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2378, H, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-2379, H, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2380, H, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2381, H,
CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-2382, H,
CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-2383, H, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2384, H,
CH.sub.3, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-2385, H, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2386, H,
CH.sub.3, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-2387, H, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-2388, H,
CH.sub.3, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-2389, H, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2390,
H, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-2391,
H, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2392,
H, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-2393, H, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-2394, H, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-2395, H, CH.sub.3, H, MeOCH.sub.2, H), (M-2396, H, CH.sub.3, H,
MeOCH.sub.2, Cl), (M-2397, H, CH.sub.3, H, MeOCH.sub.2, F),
(M-2398, H, CH.sub.3, H, MeOCH.sub.2, CF.sub.3), (M-2399, H,
CH.sub.3, H, MeOCH.sub.2, Br), (M-2400, H, CH.sub.3, H,
MeOCH.sub.2, CH.sub.3), (M-2401, H, CH.sub.3, H, EtOCH.sub.2, H),
(M-2402, H, CH.sub.3, H, EtOCH.sub.2, Cl), (M-2403, H, CH.sub.3, H,
EtOCH.sub.2, F), (M-2404, H, CH.sub.3, H, EtOCH.sub.2, CF.sub.3),
(M-2405, H, CH.sub.3, H, EtOCH.sub.2, Br), (M-2406, H, CH.sub.3, H,
EtOCH.sub.2, CH.sub.3), (M-2407, H, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, H), (M-2408, H, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, Cl), (M-2409, H, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, F), (M-2410, H, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-2411, H, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, Br), (M-2412, H, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-2413, H, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-2414, H, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-2415, H, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-2416, H, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-2417, H,
CH.sub.3, H, MeOCH.sub.2CH.sub.2OCH.sub.3, Br), (M-2418, H,
CH.sub.3, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-2419, H, CH.sub.3, H, MeOCH.sub.2CH.sub.2, H), (M-2420, H,
CH.sub.3, H, MeOCH.sub.2CH.sub.2, Cl), (M-2421, H, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, F), (M-2422, H, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-2423, H, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, Br), (M-2424, H, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-2425, H, CH.sub.3, H,
HOCH.sub.2, H), (M-2426, H, CH.sub.3, H, HOCH.sub.2, Cl), (M-2427,
H, CH.sub.3, H, HOCH.sub.2, F), (M-2428, H, CH.sub.3, H,
HOCH.sub.2, CF.sub.3), (M-2429, H, CH.sub.3, H, HOCH.sub.2, Br),
(M-2430, H, CH.sub.3, H, HOCH.sub.2, CH.sub.3), (M-2431, H,
CH.sub.3, H, HOCH.sub.2CH.sub.2, H), (M-2432, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2, Cl), (M-2433, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2, F), (M-2434, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-2435, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2, Br), (M-2436, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-2437, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-2438, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-2439, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-2440, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2441, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-2442, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-2443, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2444, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-2445, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2446, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2447, H,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-2448, H,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-2449, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-2450, H, CH.sub.3,
H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-2451, H,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-2452, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-2453, H,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br),
(M-2454, H, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-2455, H,
CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-2456, H,
CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-2457, H,
CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-2458, H,
CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-2459, H, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-2460, H, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-2461, H, CH.sub.3, H, (Me).sub.2N, H), (M-2462, H,
CH.sub.3, H, (Me).sub.2N, Cl), (M-2463, H, CH.sub.3, H,
(Me).sub.2N, F), (M-2464, H, CH.sub.3, H, (Me).sub.2N, CF.sub.3),
(M-2465, H, CH.sub.3, H, (Me).sub.2N, Br), (M-2466, H, CH.sub.3, H,
(Me).sub.2N, CH.sub.3), (M-2467, H, CH.sub.3, H,
piperidin-4-yl-methyl, H), (M-2468, H, CH.sub.3, H,
piperidin-4-yl-methyl, Cl), (M-2469, H, CH.sub.3, H,
piperidin-4-yl-methyl, F), (M-2470, H, CH.sub.3, H,
piperidin-4-yl-methyl, CF.sub.3), (M-2471, H, CH.sub.3, H,
piperidin-4-yl-methyl, Br), (M-2472, H, CH.sub.3, H,
piperidin-4-yl-methyl, CH.sub.3), (M-2473, H, CH.sub.3, H,
cyclohexylmethyl, H), (M-2474, H, CH.sub.3, H, cyclohexylmethyl,
Cl), (M-2475, H, CH.sub.3, H, cyclohexylmethyl, F), (M-2476, H,
CH.sub.3, H, cyclohexylmethyl, CF.sub.3), (M-2477, H, CH.sub.3, H,
cyclohexylmethyl, Br), (M-2478, H, CH.sub.3, H, cyclohexylmethyl,
CH.sub.3), (M-2479, H, CH.sub.3, F, H, H), (M-2480, H, CH.sub.3, F,
H, Cl), (M-2481, H, CH.sub.3, F, H, F), (M-2482, H, CH.sub.3, F, H,
CF.sub.3), (M-2483, H, CH.sub.3, F, H, Br), (M-2484, H, CH.sub.3,
F, H, CH.sub.3), (M-2485, H, CH.sub.3, F, F, H), (M-2486, H,
CH.sub.3, F, F, Cl), (M-2487, H, CH.sub.3, F, F, F), (M-2488, H,
CH.sub.3, F, F, CF.sub.3), (M-2489, H, CH.sub.3, F, F, Br),
(M-2490, H, CH.sub.3, F, F, CH.sub.3), (M-2491, H, CH.sub.3, F, Cl,
H), (M-2492, H, CH.sub.3, F, Cl, Cl), (M-2493, H, CH.sub.3, F, Cl,
F), (M-2494, H, CH.sub.3, F, Cl, CF.sub.3), (M-2495, H, CH.sub.3,
F, Cl, Br), (M-2496, H, CH.sub.3, F, Cl, CH.sub.3), (M-2497, H,
CH.sub.3, F, CH.sub.3, H), (M-2498, H, CH.sub.3, F, CH.sub.3, Cl),
(M-2499, H, CH.sub.3, F, CH.sub.3, F), (M-2500, H, CH.sub.3, F,
CH.sub.3, CF.sub.3), (M-2501, H, CH.sub.3, F, CH.sub.3, Br),
(M-2502, H, CH.sub.3, F, CH.sub.3, CH.sub.3), (M-2503, H, CH.sub.3,
F, Et, H), (M-2504, H, CH.sub.3, F, Et, Cl), (M-2505, H, CH.sub.3,
F, Et, F), (M-2506, H, CH.sub.3, F, Et, CF.sub.3), (M-2507, H,
CH.sub.3, F, Et, Br), (M-2508, H, CH.sub.3, F, Et, CH.sub.3),
(M-2509, H, CH.sub.3, F, n-Pr, H), (M-2510, H, CH.sub.3, F, n-Pr,
Cl), (M-2511, H, CH.sub.3, F, n-Pr, F), (M-2512, H, CH.sub.3, F,
n-Pr, CF.sub.3), (M-2513, H, CH.sub.3, F, n-Pr, Br), (M-2514, H,
CH.sub.3, F, n-Pr, CH.sub.3), (M-2515, H, CH.sub.3, F, c-Pr, H),
(M-2516, H, CH.sub.3, F, c-Pr, Cl), (M-2517, H, CH.sub.3, F, c-Pr,
F), (M-2518, H, CH.sub.3, F, c-Pr, CF.sub.3), (M-2519, H, CH.sub.3,
F, c-Pr, Br), (M-2520, H, CH.sub.3, F, c-Pr, CH.sub.3), (M-2521, H,
CH.sub.3, F, i-Pr, H), (M-2522, H, CH.sub.3, F, i-Pr, Cl), (M-2523,
H, CH.sub.3, F, i-Pr, F), (M-2524, H, CH.sub.3, F, i-Pr, CF.sub.3),
(M-2525, H, CH.sub.3, F, i-Pr, Br), (M-2526, H, CH.sub.3, F, i-Pr,
CH.sub.3), (M-2527, H, CH.sub.3, F, n-Bu, H), (M-2528, H, CH.sub.3,
F, n-Bu, Cl), (M-2529, H, CH.sub.3, F, n-Bu, F), (M-2530, H,
CH.sub.3, F, n-Bu, CF.sub.3), (M-2531, H, CH.sub.3, F, n-Bu, Br),
(M-2532, H, CH.sub.3, F, n-Bu, CH.sub.3), (M-2533, H, CH.sub.3, F,
i-Bu, H), (M-2534, H, CH.sub.3, F, i-Bu, Cl), (M-2535, H, CH.sub.3,
F, i-Bu, F), (M-2536, H, CH.sub.3, F, i-Bu, CF.sub.3), (M-2537, H,
CH.sub.3, F, i-Bu, Br), (M-2538, H, CH.sub.3, F, i-Bu, CH.sub.3),
(M-2539, H, CH.sub.3, F, sec-Bu, H), (M-2540, H, CH.sub.3, F,
sec-Bu, Cl), (M-2541, H, CH.sub.3, F, sec-Bu, F), (M-2542, H,
CH.sub.3, F, sec-Bu, CF.sub.3), (M-2543, H, CH.sub.3, F, sec-Bu,
Br), (M-2544, H, CH.sub.3, F, sec-Bu, CH.sub.3), (M-2545, H,
CH.sub.3, F, n-Pen, H), (M-2546, H, CH.sub.3, F, n-Pen, Cl),
(M-2547, H, CH.sub.3, F, n-Pen, F), (M-2548, H, CH.sub.3, F, n-Pen,
CF.sub.3), (M-2549, H, CH.sub.3, F, n-Pen, Br), (M-2550, H,
CH.sub.3, F, n-Pen, CH.sub.3), (M-2551, H, CH.sub.3, F, c-Pen, H),
(M-2552, H, CH.sub.3, F, c-Pen, Cl), (M-2553, H, CH.sub.3, F,
c-Pen, F), (M-2554, H, CH.sub.3, F, c-Pen, CF.sub.3), (M-2555, H,
CH.sub.3, F, c-Pen, Br), (M-2556, H, CH.sub.3, F, c-Pen, CH.sub.3),
(M-2557, H, CH.sub.3, F, n-Hex, H), (M-2558, H, CH.sub.3, F, n-Hex,
Cl), (M-2559, H, CH.sub.3, F, n-Hex, F), (M-2560, H, CH.sub.3, F,
n-Hex, CF.sub.3), (M-2561, H, CH.sub.3, F, n-Hex, Br), (M-2562, H,
CH.sub.3, F, n-Hex, CH.sub.3), (M-2563, H, CH.sub.3, F, c-Hex, H),
(M-2564, H, CH.sub.3, F, c-Hex, Cl), (M-2565, H, CH.sub.3, F,
c-Hex, F), (M-2566, H, CH.sub.3, F, c-Hex, CF.sub.3), (M-2567, H,
CH.sub.3, F, c-Hex, Br), (M-2568, H, CH.sub.3, F, c-Hex, CH.sub.3),
(M-2569, H, CH.sub.3, F, OH, H), (M-2570, H, CH.sub.3, F, OH, Cl),
(M-2571, H, CH.sub.3, F, OH, F), (M-2572, H, CH.sub.3, F, OH,
CF.sub.3), (M-2573, H, CH.sub.3, F, OH, Br), (M-2574, H, CH.sub.3,
F, OH, CH.sub.3), (M-2575, H, CH.sub.3, F, EtO, H), (M-2576, H,
CH.sub.3, F, EtO, Cl), (M-2577, H, CH.sub.3, F, EtO, F), (M-2578,
H, CH.sub.3, F, EtO, CF.sub.3), (M-2579, H, CH.sub.3, F, EtO, Br),
(M-2580, H, CH.sub.3, F, EtO, CH.sub.3), (M-2581, H, CH.sub.3, F,
n-PrO, H), (M-2582, H, CH.sub.3, F, n-PrO, Cl), (M-2583, H,
CH.sub.3, F, n-PrO, F), (M-2584, H, CH.sub.3, F, n-PrO, CF.sub.3),
(M-2585, H, CH.sub.3, F, n-PrO, Br), (M-2586, H, CH.sub.3, F,
n-PrO, CH.sub.3), (M-2587, H, CH.sub.3, F, PhO, H), (M-2588, H,
CH.sub.3, F, PhO, Cl), (M-2589, H, CH.sub.3, F, PhO, F), (M-2590,
H, CH.sub.3, F, PhO, CF.sub.3), (M-2591, H, CH.sub.3, F, PhO, Br),
(M-2592, H, CH.sub.3, F, PhO, CH.sub.3), (M-2593, H, CH.sub.3, F,
BnO, H), (M-2594, H, CH.sub.3, F, BnO, Cl), (M-2595, H, CH.sub.3,
F, BnO, F), (M-2596, H, CH.sub.3, F, BnO, CF.sub.3), (M-2597, H,
CH.sub.3, F, BnO, Br), (M-2598, H, CH.sub.3, F, BnO, CH.sub.3),
(M-2599, H, CH.sub.3, F, PhCH.sub.2CH.sub.2O, H), (M-2600, H,
CH.sub.3, F, PhCH.sub.2CH.sub.2O, Cl), (M-2601, H, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, F), (M-2602, H, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-2603, H, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, Br), (M-2604, H, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-2605, H, CH.sub.3, F, CF.sub.3O,
H), (M-2606, H, CH.sub.3, F, CF.sub.3O, Cl), (M-2607, H, CH.sub.3,
F, CF.sub.3O, F), (M-2608, H, CH.sub.3, F, CF.sub.3O, CF.sub.3),
(M-2609, H, CH.sub.3, F, CF.sub.3O, Br), (M-2610, H, CH.sub.3, F,
CF.sub.3O, CH.sub.3), (M-2611, H, CH.sub.3, F, Ph, H), (M-2612, H,
CH.sub.3, F, Ph, Cl), (M-2613, H, CH.sub.3, F, Ph, F), (M-2614, H,
CH.sub.3, F, Ph, CF.sub.3), (M-2615, H, CH.sub.3, F, Ph, Br),
(M-2616, H, CH.sub.3, F, Ph, CH.sub.3), (M-2617, H, CH.sub.3, F,
4-F-Ph, H), (M-2618, H, CH.sub.3, F, 4-F-Ph, Cl), (M-2619, H,
CH.sub.3, F, 4-F-Ph, F), (M-2620, H, CH.sub.3, F, 4-F-Ph,
CF.sub.3), (M-2621, H, CH.sub.3, F, 4-F-Ph, Br), (M-2622, H,
CH.sub.3, F, 4-F-Ph, CH.sub.3), (M-2623, H, CH.sub.3, F,
4-CF.sub.3-Ph, H), (M-2624, H, CH.sub.3, F, 4-CF.sub.3-Ph, Cl),
(M-2625, H, CH.sub.3, F, 4-CF.sub.3-Ph, F), (M-2626, H, CH.sub.3,
F, 4-CF.sub.3-Ph, CF.sub.3), (M-2627, H, CH.sub.3, F,
4-CF.sub.3-Ph, Br), (M-2628, H, CH.sub.3, F, 4-CF.sub.3-Ph,
CH.sub.3), (M-2629, H, CH.sub.3, F, 4-(Me).sub.2N-Ph, H), (M-2630,
H, CH.sub.3, F, 4-(Me).sub.3N-Ph, Cl), (M-2631, H, CH.sub.3, F,
4-(Me).sub.2N-Ph, F), (M-2632, H, CH.sub.3, F, 4-(Me).sub.2N-Ph,
CF.sub.3), (M-2633, H, CH.sub.3, F, 4-(Me).sub.2N-Ph, Br), (M-2634,
H, CH.sub.3, F, 4-(Me).sub.2N-Ph, CH.sub.3
), (M-2635, H, CH.sub.3, F, 4-OH-Ph, H), (M-2636, H, CH.sub.3, F,
4-OH-Ph, Cl), (M-2637, H, CH.sub.3, F, 4-OH-Ph, F), (M-2638, H,
CH.sub.3, F, 4-OH-Ph, CF.sub.3), (M-2639, H, CH.sub.3, F, 4-OH-Ph,
Br), (M-2640, H, CH.sub.3, F, 4-OH-Ph, CH.sub.3), (M-2641, H,
CH.sub.3, F, 3,4-di-F-Ph, H), (M-2642, H, CH.sub.3, F, 3,4-di-F-Ph,
Cl), (M-2643, H, CH.sub.3, F, 3,4-di-F-Ph, F), (M-2644, H,
CH.sub.3, F, 3,4-di-F-Ph, CF.sub.3), (M-2645, H, CH.sub.3, F,
3,4-di-F-Ph, Br), (M-2646, H, CH.sub.3, F, 3,4-di-F-Ph, CH.sub.3),
(M-2647, H, CH.sub.3, F, 4-COOH-Ph, H), (M-2648, H, CH.sub.3, F,
4-COOH-Ph, Cl), (M-2649, H, CH.sub.3, F, 4-COOH-Ph, F), (M-2650, H,
CH.sub.3, F, 4-COOH-Ph, CF.sub.3), (M-2651, H, CH.sub.3, F,
4-COOH-Ph, Br), (M-2652, H, CH.sub.3, F, 4-COOH-Ph, CH.sub.3),
(M-2653, H, CH.sub.3, F, Bn, H), (M-2654, H, CH.sub.31 F, Bn, Cl),
(M-2655, H, CH.sub.3F, Bn, F), (M-2656, H, CH.sub.3, F, Bn,
CF.sub.3), (M-2657, H, CH.sub.3, F, Bn, Br), (M-2658, H, CH.sub.3,
F, Bn, CH.sub.3), (M-2659, H, CH.sub.3, F, 4-F-Bn, H), (M-2660, H,
CH.sub.3, F, 4-F-Bn, Cl), (M-2661, H, CH.sub.3, F, 4-F-Bn, F),
(M-2662, H, CH.sub.3, F, 4-F-Bn, CF.sub.3), (M-2663, H, CH.sub.3,
F, 4-F-Bn, Br), (M-2664, H, CH.sub.3, F, 4-F-Bn, CH.sub.3),
(M-2665, H, CH.sub.3, F, 2-Py, H), (M-2666, H, CH.sub.3, F, 2-Py,
Cl), (M-2667, H, CH.sub.3, F, 2-Py, F), (M-2668, H, CH.sub.3, F,
2-Py, CF.sub.3), (M-2669, H, CH.sub.3, F, 2-Py, Br), (M-2670, H,
CH.sub.3, F, 2-Py, CH.sub.3), (M-2671, H, CH.sub.3, F, 3-Py, H),
(M-2672, H, CH.sub.3, F, 3-Py, Cl), (M-2673, H, CH.sub.3, F, 3-Py,
F), (M-2674, H, CH.sub.3, F, 3-Py, CF.sub.3), (M-2675, H, CH.sub.3,
F, 3-Py, Br), (M-2676, H, CH.sub.3, F, 3-Py, CH.sub.3), (M-2677, H,
CH.sub.3, F, 4-Py, H), (M-2678, H, CH.sub.3, F, 4-Py, Cl), (M-2679,
H, CH.sub.3, F, 4-Py, F), (M-2680, H, CH.sub.3, F, 4-Py, CF.sub.3),
(M-2681, H, CH.sub.3, F, 4-Py, Br), (M-2682, H, CH.sub.3, F, 4-Py,
CH.sub.3), (M-2683, H, CH.sub.3, F, 2-Th, H), (M-2684, H, CH.sub.3,
F, 2-Th, Cl), (M-2685, H, CH.sub.3, F, 2-Th, F), (M-2686, H,
CH.sub.3, F, 2-Th, CF.sub.3), (M-2687, H, CH.sub.3, F, 2-Th, Br),
(M-2688, H, CH.sub.3, F, 2-Th, CH.sub.3), (M-2689, H, CH.sub.3, F,
3-Th, H), (M-2690, H, CH.sub.3, F, 3-Th, Cl), (M-2691, H, CH.sub.3,
F, 3-Th, F), (M-2692, H, CH.sub.3, F, 3-Th, CF.sub.3), (M-2693, H,
CH.sub.3, F, 3-Th, Br), (M-2694, H, CH.sub.3, F, 3-Th, CH.sub.3),
(M-2695, H, CH.sub.3, F, pyrrazol-2-yl, H), (M-2696, H, CH.sub.3,
F, pyrrazol-2-yl, Cl), (M-2697, H, CH.sub.3, F, pyrazolyl, F),
(M-2698, H, CH.sub.3, F, pyrrazol-2-yl, CF.sub.3), (M-2699, H,
CH.sub.3, F, pyrrazol-2-yl, Br), (M-2700, H, CH.sub.3, F,
pyrrazol-2-yl, CH.sub.3), (M-2701, H, CH.sub.3, F, pyrrazol-3-yl,
H), (M-2702, H, CH.sub.3, F, pyrrazol-3-yl, Cl), (M-2703, H,
CH.sub.3, F, pyrrazol-3-yl, F), (M-2704, H, CH.sub.3, F,
pyrrazol-3-yl, CF.sub.3), (M-2705, H, CH.sub.3, F, pyrrazol-3-yl,
Br), (M-2706, H, CH.sub.3, F, pyrazol-3-yl, CH.sub.3), (M-2707, H,
CH.sub.3, F, pyrimidin-2-yl, H), (M-2708, H, CH.sub.3, F,
pyrimidin-2-yl, Cl), (M-2709, H, CH.sub.3, F, pyrimidin-2-yl, F),
(M-2710, H, CH.sub.3, F, pyrimidin-2-yl, CF.sub.3), (M-2711, H,
CH.sub.3, F, pyrimidin-2-yl, Br), (M-2712, H, CH.sub.3, F,
pyrimidin-2-yl, CH.sub.3), (M-2713, H, CH.sub.3, F, pyrimidin-4-yl,
H), (M-2714, H, CH.sub.3, F, pyrimidin-4-yl, Cl), (M-2715, H,
CH.sub.3, F, pyrimidin-4-yl, F), (M-2716, H, CH.sub.3, F,
pyrimidin-4-yl, CF.sub.3), (M-2717, H, CH.sub.3, F, pyrimidin-4-yl,
Br), (M-2718, H, CH.sub.3, F, pyrimidin-4-yl, CH.sub.3), (M-2719,
H, CH.sub.3, F, pyrimidin-5-yl, H), (M-2720, H, CH.sub.3, F,
pyrimidin-5-yl, Cl), (M-2721, H, CH.sub.3, F, pyrimidin-5-yl, F),
(M-2722, H, CH.sub.3, F, pyrimidin-5-yl, CF.sub.3), (M-2723, H,
CH.sub.3, F, pyrimidin-5-yl, Br), (M-2724, H, CH.sub.3, F,
pyrimidin-5-yl, CH.sub.3), (M-2725, H, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2H), (M-2726, H, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-2727, H, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-2728, H, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2729, H, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2Br), (M-2730, H, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-2731, H, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2732, H, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-2733, H, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2734, H, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2735, H,
CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-2736, H,
CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-2737, H, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2738, H,
CH.sub.3, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-2739, H, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2740, H,
CH.sub.3, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-2741, H, CH.sub.3, F,
(Me).sub.2NCOCH.sub.3CH.sub.2CH.sub.2CH.sub.2, Br), (M-2742, H,
CH.sub.3, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-2743, H, CH.sub.3, F,
(Me).sub.3NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2744,
H, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-2745, H, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2746,
H, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-2747, H, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-2748, H, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-2749, H, CH.sub.3, F, MeOCH.sub.2, H), (M-2750, H, CH.sub.3, F,
MeOCH.sub.2, Cl), (M-2751, H, CH.sub.3, F, MeOCH.sub.2, F),
(M-2752, H, CH.sub.3, F, MeOCH.sub.2, CF.sub.3), (M-2753, H,
CH.sub.3, F, MeOCH.sub.2, Br), (M-2754, H, CH.sub.3, F,
MeOCH.sub.2, CH.sub.3), (M-2755, H, CH.sub.3, F, EtOCH.sub.2, H),
(M-2756, H, CH.sub.3, F, EtOCH.sub.2, Cl), (M-2757, H, CH.sub.3, F,
EtOCH.sub.2, F), (M-2758, H, CH.sub.3, F, EtOCH.sub.2, CF.sub.3),
(M-2759, H, CH.sub.3, F, EtOCH.sub.2, Br), (M-2760, H, CH.sub.3, F,
EtOCH.sub.2, CH.sub.3), (M-2761, H, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, H), (M-2762, H, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, Cl), (M-2763, H, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, F), (M-2764, H, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-2765, H, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, Br), (M-2766, H, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-2767, H, CH.sub.3, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-2768, H, CH.sub.3, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-2769, H, CH.sub.3, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-2770, H, CH.sub.3, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-2771, H,
CH.sub.3, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-2772, H,
CH.sub.3, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-2773, H, CH.sub.3, F, MeOCH.sub.2CH.sub.2, H), (M-2774, H,
CH.sub.3, F, MeOCH.sub.2CH.sub.2, Cl), (M-2775, H, CH.sub.3, F,
MeOCH.sub.2CH.sub.2, F), (M-2776, H, CH.sub.3, F,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-2777, H, CH.sub.3, F,
MeOCH.sub.2CH.sub.2, Br), (M-2778, H, CH.sub.3, F,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-2779, H, CH.sub.3, F,
HOCH.sub.2, H), (M-2780, H, CH.sub.3, F, HOCH.sub.2, Cl), (M-2781,
H, CH.sub.3, F, HOCH.sub.2, F), (M-2782, H, CH.sub.3, F,
HOCH.sub.2, CF.sub.3), (M-2783, H, CH.sub.3, F, HOCH.sub.2, Br),
(M-2784, H, CH.sub.3, F, HOCH.sub.2, CH.sub.3), (M-2785, H,
CH.sub.3, F, HOCH.sub.2CH.sub.3, H), (M-2786, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2, Cl), (M-2787, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2, F), (M-2788, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-2789, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2, Br), (M-2790, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-2791, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-2792, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-2793, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-2794, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2795, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-2796, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-2797, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2798, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-2799, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2800, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-2801, H,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-2802, H,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-2803, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-2804, H,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl),
(M-2805, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-2806, H,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-2807, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-2808, H,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3),
(M-2809, H, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H),
(M-2810, H, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-2811, H, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-2812, H, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CF.sub.3), (M-2813, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-2814, H, CH.sub.3, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-2815, H,
CH.sub.3, F, (Me).sub.2N, H), (M-2816, H, CH.sub.3, F, (Me).sub.2N,
Cl), (M-2817, H, CH.sub.3, F, (Me).sub.2N, F), (M-2818, H,
CH.sub.3, F, (Me).sub.2N, CF.sub.3), (M-2819, H, CH.sub.3, F,
(Me).sub.2N, Br), (M-2820, H, CH.sub.3, F, (Me).sub.2N, CH.sub.3),
(M-2821, H, CH.sub.3, F, piperidin-4-yl-methyl, H), (M-2822, H,
CH.sub.3, F, piperidin-4-yl-methyl, Cl), (M-2823, H, CH.sub.3, F,
piperidin-4-yl-methyl, F), (M-2824, H, CH.sub.3, F,
piperidin-4-yl-methyl, CF.sub.3), (M-2825, H, CH.sub.3, F,
piperidin-4-yl-methyl, Br), (M-2826, H, CH.sub.3, F,
piperidin-4-yl-methyl, CH.sub.3), (M-2827, H, CH.sub.3, F,
cyclohexylmethyl, H), (M-2828, H, CH.sub.3, F, cyclohexylmethyl,
Cl), (M-2829, H, CH.sub.3, F, cyclohexylmethyl, F), (M-2830, H,
CH.sub.3, F, cyclohexylmethyl, CF.sub.3), (M-2831, H, CH.sub.3, F,
cyclohexylmethyl, Br), (M-2832, H, CH.sub.3, F, cyclohexylmethyl,
CH.sub.3), (M-2833, H, CH.sub.3, Cl, H, H), (M-2834, H, CH.sub.3,
Cl, H, Cl), (M-2835, H, CH.sub.3, Cl, H, F), (M-2836, H, CH.sub.3,
Cl, H, CF.sub.3), (M-2837, H, CH.sub.3, Cl, H, Br), (M-2838, H,
CH.sub.3, Cl, H, CH.sub.3), (M-2839, H, CH.sub.3, Cl, F, H),
(M-2840, H, CH.sub.3, Cl, F, Cl), (M-2841, H, CH.sub.3, Cl, F, F),
(M-2842, H, CH.sub.3, Cl, F, CF.sub.3), (M-2843, H, CH.sub.3, Cl,
F, Br), (M-2844, H, CH.sub.3, Cl, F, CH.sub.3), (M-2845, H,
CH.sub.3, Cl, Cl, H), (M-2846, H, CH.sub.3, Cl, Cl, Cl), (M-2847,
H, CH.sub.3, Cl, Cl, F), (M-2848, H, CH.sub.3, Cl, Cl, CF.sub.3),
(M-2849, H, CH.sub.3, Cl, Cl, Br), (M-2850, H, CH.sub.3, Cl, Cl,
CH.sub.3), (M-2851, H, CH.sub.3, Cl, CH.sub.3, H), (M-2852, H,
CH.sub.3, Cl, CH.sub.3, Cl), (M-2853, H, CH.sub.3, Cl, CH.sub.3,
F), (M-2854, H, CH.sub.3, Cl, CH.sub.3, CF.sub.3), (M-2855, H,
CH.sub.3, Cl, CH.sub.3, Br), (M-2856, H, CH.sub.3, Cl, CH.sub.3,
CH.sub.3), (M-2857, H, CH.sub.3, Cl, Et, H), (M-2858, H, CH.sub.3,
Cl, Et, Cl), (M-2859, H, CH.sub.3, Cl, Et, F), (M-2860, H,
CH.sub.3, Cl, Et, CF.sub.3), (M-2861, H, CH.sub.3, Cl, Et, Br),
(M-2862, H, CH.sub.3, Cl, Et, CH.sub.3), (M-2863, H, CH.sub.3, Cl,
n-Pr, H), (M-2864, H, CH.sub.3, Cl, n-Pr, Cl), (M-2865, H,
CH.sub.3, Cl, n-Pr, F), (M-2866, H, CH.sub.3, Cl, n-Pr, CF.sub.3),
(M-2867, H, CH.sub.3, Cl, n-Pr, Br), (M-2868, H, CH.sub.3, Cl,
n-Pr, CH.sub.3), (M-2869, H, CH.sub.3, Cl, c-Pr, H), (M-2870, H,
CH.sub.3, Cl, c-Pr, Cl), (M-2871, H, CH.sub.3, Cl, c-Pr, F),
(M-2872, H, CH.sub.3, Cl, c-Pr, CF.sub.3), (M-2873, H, CH.sub.3,
Cl, c-Pr, Br), (M-2874, H, CH.sub.3, Cl, c-Pr, CH.sub.3), (M-2875,
H, CH.sub.3, Cl, i-Pr, H), (M-2876, H, CH.sub.3, Cl, i-Pr, Cl),
(M-2877, H, CH.sub.3, Cl, i-Pr, F), (M-2878, H, CH.sub.3, Cl, i-Pr,
CF.sub.3), (M-2879, H, CH.sub.3, Cl, i-Pr, Br), (M-2880, H,
CH.sub.3, Cl, i-Pr, CH.sub.3), (M-2881, H, CH.sub.3, Cl, n-Bu, H),
(M-2882, H, CH.sub.3, Cl, n-Bu, Cl), (M-2883, H, CH.sub.3, Cl,
n-Bu, F), (M-2884, H, CH.sub.3, Cl, n-Bu, CF.sub.3), (M-2885, H,
CH.sub.3, Cl, n-Bu, Br), (M-2886, H, CH.sub.3, Cl, n-Bu, CH.sub.3),
(M-2887, H, CH.sub.3, Cl, i-Bu, H), (M-2888, H, CH.sub.3, Cl, i-Bu,
Cl), (M-2889, H, CH.sub.3, Cl, i-Bu, F), (M-2890, H, CH.sub.3, Cl,
i-Bu, CF.sub.3), (M-2891, H, CH.sub.3, Cl, i-Bu, Br), (M-2892, H,
CH.sub.3, Cl, i-Bu, CH.sub.3), (M-2893, H, CH.sub.3, Cl, sec-Bu,
H), (M-2894, H, CH.sub.3, Cl, sec-Bu, Cl), (M-2895, H, CH.sub.3,
Cl, sec-Bu, F), (M-2896, H, CH.sub.3, Cl, sec-Bu, CF.sub.3),
(M-2897, H, CH.sub.3, Cl, sec-Bu, Br), (M-2898, H, CH.sub.3, Cl,
sec-Bu, CH.sub.3), (M-2899, H, CH.sub.3, Cl, n-Pen, H), (M-2900, H,
CH.sub.3, Cl, n-Pen, Cl), (M-2901, H, CH.sub.3, Cl, n-Pen, F),
(M-2902, H, CH.sub.3, Cl, n-Pen, CF.sub.3), (M-2903, H, CH.sub.3,
Cl, n-Pen, Br), (M-2904, H, CH.sub.3, Cl, n-Pen, CH.sub.3),
(M-2905, H, CH.sub.3, Cl, c-Pen, H), (M-2906, H, CH.sub.3, Cl,
c-Pen, Cl), (M-2907, H, CH.sub.3, Cl, c-Pen, F), (M-2908, H,
CH.sub.3, Cl, c-Pen, CF.sub.3), (M-2909, H, CH.sub.3, Cl, c-Pen,
Br), (M-2910, H, CH.sub.3, Cl, c-Pen, CH.sub.3), (M-2911, H,
CH.sub.3, Cl, n-Hex, H), (M-2912, H, CH.sub.3, Cl, n-Hex, Cl),
(M-2913, H, CH.sub.3, Cl, n-Hex, F), (M-2914, H, CH.sub.3, Cl,
n-Hex, CF.sub.3), (M-2915, H, CH.sub.3, Cl, n-Hex, Br), (M-2916, H,
CH.sub.3, Cl, n-Hex, CH.sub.3), (M-2917, H, CH.sub.3, Cl, c-Hex,
H), (M-2918, H, CH.sub.3, Cl, c-Hex, Cl), (M-2919, H, CH.sub.3, Cl,
c-Hex, F), (M-2920, H, CH.sub.3, Cl, c-Hex, CF.sub.3), (M-2921, H,
CH.sub.3, Cl, c-Hex, Br), (M-2922, H, CH.sub.3, Cl, c-Hex,
CH.sub.3), (M-2923, H, CH.sub.3, Cl, OH, H), (M-2924, H, CH.sub.3,
Cl, OH, Cl), (M-2925, H, CH.sub.3, Cl, OH, F), (M-2926, H,
CH.sub.3, Cl, OH, CF.sub.3), (M-2927, H, CH.sub.3, Cl, OH, Br),
(M-2928, H, CH.sub.3, Cl, OH, CH.sub.3), (M-2929, H, CH.sub.3, Cl,
EtO, H), (M-2930, H, CH.sub.3, Cl, EtO, Cl), (M-2931, H, CH.sub.3,
Cl, EtO, F), (M-2932, H, CH.sub.3, Cl, EtO, CF.sub.3), (M-2933, H,
CH.sub.3, Cl, EtO, Br), (M-2934, H, CH.sub.3, Cl, EtO, CH.sub.3),
(M-2935, H, CH.sub.3, Cl, n-PrO, H), (M-2936, H, CH.sub.3, Cl,
n-PrO, Cl), (M-2937, H, CH.sub.3, Cl, n-PrO, F), (M-2938, H,
CH.sub.3, Cl, n-PrO, CF.sub.3), (M-2939, H, CH.sub.3, Cl, n-PrO,
Br), (M-2940, H, CH.sub.3, Cl, n-PrO, CH.sub.3), (M-2941, H,
CH.sub.3, Cl, PhO, H), (M-2942, H, CH.sub.3, Cl, PhO, Cl), (M-2943,
H, CH.sub.3, Cl, PhO, F), (M-2944, H, CH.sub.3, Cl, PhO, CF.sub.3),
(M-2945, H, CH.sub.3, Cl, PhO, Br), (M-2946, H, CH.sub.3, Cl, PhO,
CH.sub.3), (M-2947, H, CH.sub.3, Cl, BnO, H), (M-2948, H, CH.sub.3,
Cl, BnO, Cl), (M-2949, H, CH.sub.3, Cl, BnO, F), (M-2950, H,
CH.sub.3, Cl, BnO, CF.sub.3), (M-2951, H, CH.sub.3, Cl, BnO, Br),
(M-2952, H, CH.sub.3, Cl, BnO, CH.sub.3), (M-2953, H, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, H), (M-2954, H, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, Cl), (M-2955, H, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, F), (M-2956, H, CH
.sub.3, Cl, PhCH.sub.2CH.sub.2O, CF.sub.3), (M-2957, H, CH.sub.3,
Cl, PhCH.sub.2CH.sub.2O, Br), (M-2958, H, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-2959, H, CH.sub.3, Cl,
CF.sub.3O, H), (M-2960, H, CH.sub.3, Cl, CF.sub.3O, Cl), (M-2961,
H, CH.sub.3, Cl, CF.sub.3O, F), (M-2962, H, CH.sub.3, Cl,
CF.sub.3O, CF.sub.3), (M-2963, H, CH.sub.3, Cl, CF.sub.3O, Br),
(M-2964, H, CH.sub.3, Cl, CF.sub.3O, CH.sub.3), (M-2965, H,
CH.sub.3, Cl, Ph, H), (M-2966, H, CH.sub.3, Cl, Ph, Cl), (M-2967,
H, CH.sub.3, Cl, Ph, F), (M-2968, H, CH.sub.3, Cl, Ph, CF.sub.3),
(M-2969, H, CH.sub.3, Cl, Ph, Br), (M-2970, H, CH.sub.3, Cl, Ph,
CH.sub.3), (M-2971, H, CH.sub.3, Cl, 4-F-Ph, H), (M-2972, H,
CH.sub.3, Cl, 4-F-Ph, Cl), (M-2973, H, CH.sub.3, Cl, 4-F-Ph, F),
(M-2974, H, CH.sub.3, Cl, 4-F-Ph, CF.sub.3), (M-2975, H, CH.sub.3,
Cl, 4-F-Ph, Br), (M-2976, H, CH.sub.3, Cl, 4-F-Ph, CH.sub.3),
(M-2977, H, CH.sub.3, Cl, 4-CF.sub.3-Ph, H), (M-2978, H, CH.sub.3,
Cl, 4-CF.sub.3-Ph, Cl), (M-2979, H, CH.sub.3, Cl, 4-CF.sub.3-Ph,
F), (M-2980, H, CH.sub.3, Cl, 4-CF.sub.3-Ph, CF.sub.3), (M-2981, H,
CH.sub.3, Cl, 4-CF.sub.3-Ph, Br), (M-2982, H, CH.sub.3, Cl,
4-CF.sub.3-Ph, CH.sub.3), (M-2983, H, CH.sub.3, Cl,
4-(Me).sub.2N-Ph, H), (M-2984, H, CH.sub.3, Cl, 4-(Me).sub.2N-Ph,
Cl), (M-2985, H, CH.sub.3, Cl, 4-(Me).sub.2N-Ph, F), (M-2986, H,
CH.sub.3, Cl, 4-(Me).sub.2N-Ph, CF.sub.3), (M-2987, H, CH.sub.3,
Cl, 4-(Me).sub.2N-Ph, Br), (M-2988, H, CH.sub.3, Cl,
4-(Me).sub.2N-Ph, CH.sub.3), (M-2989, H, CH.sub.3, Cl, 4-OH-Ph, H),
(M-2990, H, CH.sub.3, Cl, 4-OH-Ph, Cl), (M-2991, H, CH.sub.3, Cl,
4-OH-Ph, F), (M-2992, H, CH.sub.3, Cl, 4-OH-Ph, CF.sub.3), (M-2993,
H, CH.sub.3, Cl, 4-OH-Ph, Br), (M-2994, H, CH.sub.3, Cl, 4-OH-Ph,
CH.sub.3), (M-2995, H, CH.sub.3, Cl, 3,4-di-F-Ph, H), (M-2996, H,
CH.sub.3, Cl, 3,4-di-F-Ph, Cl), (M-2997, H, CH.sub.3, Cl,
3,4-di-F-Ph, F), (M-2998, H, CH.sub.3, Cl, 3,4-di-F-Ph, CF.sub.3),
(M-2999, H, CH.sub.3, Cl, 3,4-di-F-Ph, Br), (M-3000, H, CH.sub.3,
Cl, 3,4-di-F-Ph, CH.sub.3), (M-3001, H, CH.sub.3, Cl, 4-COOH-Ph,
H), (M-3002, H, CH.sub.3, Cl, 4-COOH-Ph, Cl), (M-3003, H, CH.sub.3,
Cl, 4-COOH-Ph, F), (M-3004, H, CH.sub.3, Cl, 4-COOH-Ph, CF.sub.3),
(M-3005, H, CH.sub.3, Cl, 4-COOH-Ph, Br), (M-3006, H, CH.sub.3, Cl,
4-COOH-Ph, CH.sub.3), (M-3007, H, CH.sub.3, Cl, Bn, H), (M-3008, H,
CH.sub.3, Cl, Bn, Cl), (M-3009, H, CH.sub.3, Cl, Bn, F), (M-3010,
H, CH.sub.3, Cl, Bn, CF.sub.3), (M-3011, H, CH.sub.3, Cl, Bn, Br),
(M-3012, H, CH.sub.3, Cl, Bn, CH.sub.3), (M-3013, H, CH.sub.3, Cl,
4-F-Bn, H), (M-3014, H, CH.sub.3, Cl, 4-F-Bn, Cl), (M-3015, H,
CH.sub.3, Cl, 4-F-Bn, F), (M-3016, H, CH.sub.3, Cl, 4-F-Bn,
CF.sub.3), (M-3017, H, CH.sub.3, Cl, 4-F-Bn, Br), (M-3018, H,
CH.sub.3, Cl, 4-F-Bn, CH.sub.3), (M-3019, H, CH.sub.3, Cl, 2-Py,
H), (M-3020, H, CH.sub.3, Cl, 2-Py, Cl), (M-3021, H, CH.sub.3, Cl,
2-Py, F), (M-3022, H, CH.sub.3, Cl, 2-Py, CF.sub.3), (M-3023, H,
CH.sub.3, Cl, 2-Py, Br), (M-3024, H, CH.sub.3, Cl, 2-Py, CH.sub.3),
(M-3025, H, CH.sub.3, Cl, 3-Py, H), (M-3026, H, CH.sub.3, Cl, 3-Py,
Cl), (M-3027, H, CH.sub.3, Cl, 3-Py, F), (M-3028, H, CH.sub.3, Cl,
3-Py, CF.sub.3), (M-3029, H, CH.sub.3, Cl, 3-Py, Br), (M-3030, H,
CH.sub.3, Cl, 3-Py, CH.sub.3), (M-3031, H, CH.sub.3, Cl, 4-Py, H),
(M-3032, H, CH.sub.3, Cl, 4-Py, Cl), (M-3033, H, CH.sub.3, Cl,
4-Py, F), (M-3034, H, CH.sub.3, Cl, 4-Py, CF.sub.3), (M-3035, H,
CH.sub.3, Cl, 4-Py, Br), (M-3036, H, CH.sub.3, Cl, 4-Py, CH.sub.3),
(M-3037, H, CH.sub.3, Cl, 2-Th, H), (M-3038, H, CH.sub.3, Cl, 2-Th,
Cl), (M-3039, H, CH.sub.3, Cl, 2-Th, F), (M-3040, H, CH.sub.3, Cl,
2-Th, CF.sub.3), (M-3041, H, CH.sub.3, Cl, 2-Th, Br), (M-3042, H,
CH.sub.3, Cl, 2-Th, CH.sub.3), (M-3043, H, CH.sub.3, Cl, 3-Th, H),
(M-3044, H, CH.sub.3, Cl, 3-Th, Cl), (M-3045, H, CH.sub.3, Cl,
3-Th, F), (M-3046, H, CH.sub.3, Cl, 3-Th, CF.sub.3), (M-3047, H,
CH.sub.3, Cl, 3-Th, Br), (M-3048, H, CH.sub.3, Cl, 3-Th, CH.sub.3),
(M-3049, H, CH.sub.3, Cl, pyrrazol-2-yl, H), (M-3050, H, CH.sub.3,
Cl, pyrrazol-2-yl, Cl), (M-3051, H, CH.sub.3, Cl, pyrrazol-2-yl,
F), (M-3052, H, CH.sub.3, Cl, pyrrazol-2-yl, CF.sub.3), (M-3053, H,
CH.sub.3, Cl, pyrrazol-2-yl, Br), (M-3054, H, CH.sub.3, Cl,
pyrrazol-2-yl, CH.sub.3), (M-3055, H, CH.sub.3, Cl, pyrrazol-3-yl,
H), (M-3056, H, CH.sub.3, Cl, pyrrazol-3-yl, Cl), (M-3057, H,
CH.sub.3, Cl, pyrrazol-3-yl, F), (M-3058, H, CH.sub.3, Cl,
pyrrazol-3-yl, CF.sub.3), (M-3059, H, CH.sub.3, Cl, pyrrazol-3-yl,
Br), (M-3060, H, CH.sub.3, Cl, pyrrazol-3-yl, CH.sub.3), (M-3061,
H, CH.sub.3, Cl, pyrimidin-2-yl, H), (M-3062, H, CH.sub.3, Cl,
pyrimidin-2-yl, Cl), (M-3063, H, CH.sub.3, Cl, pyrimidin-2-yl, F),
(M-3064, H, CH.sub.3, Cl, pyrimidin-2-yl, CF.sub.3), (M-3065, H,
CH.sub.3, Cl, pyrimidin-2-yl, Br), (M-3066, H, CH.sub.3, Cl,
pyrimidin-2-yl, CH.sub.3), (M-3067, H, CH.sub.3, Cl,
pyrimidin-4-yl, H), (M-3068, H, CH.sub.3, Cl, pyrimidin-4-yl, Cl),
(M-3069, H, CH.sub.3, Cl, pyrimidin-4-yl, F), (M-3070, H, CH.sub.3,
Cl, pyrimidin-4-yl, CF.sub.3), (M-3071, H, CH.sub.3, Cl,
pyrimidin-4-yl, Br), (M-3072, H, CH.sub.3, Cl, pyrimidin-4-yl,
CH.sub.3), (M-3073, H, CH.sub.3, Cl, pyrimidin-5-yl, H), (M-3074,
H, CH.sub.3, Cl, pyrimidin-4-yl, Cl), (M-3075, H, CH.sub.3, Cl,
pyrimidin-5-yl, F), (M-3076, H, CH.sub.3, Cl, pyrimidin-5-yl,
CF.sub.3), (M-3077, H, CH.sub.3, Cl, pyrimidin-5-yl, Br), (M-3078,
H, CH.sub.3, Cl, pyrimidin-5-yl, CH.sub.3), (M-3079, H, CH.sub.3,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-3080, H, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-3081, H, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-3082, H, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3083, H, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-3084, H, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-3085, H, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3086, H, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-3087, H, CH.sub.3,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3088, H, CH.sub.3,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3089, H,
CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-3090,
H, CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-3091, H, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3092, H,
CH.sub.3, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-3093, H, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3094, H,
CH.sub.3, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-3095, H, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-3096, H,
CH.sub.3, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-3097, H, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3098,
H, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-3099, H, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3100,
H, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-3101, H, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-3102,
H, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-3103, H, CH.sub.3, Cl, MeOCH.sub.2, H), (M-3104, H, CH.sub.3,
Cl, MeOCH.sub.2, Cl), (M-3105, H, CH.sub.3, Cl, MeOCH.sub.2, F),
(M-3106, H, CH.sub.3, Cl, MeOCH.sub.2, CF.sub.3), (M-3107, H,
CH.sub.3, Cl, MeOCH.sub.2, Br), (M-3108, H, CH.sub.3, Cl,
MeOCH.sub.2, CH.sub.3), (M-3109, H, CH.sub.3, Cl, EtOCH.sub.2, H),
(M-3110, H, CH.sub.3, Cl, EtOCH.sub.2, Cl), (M-3111, H, CH.sub.3,
Cl, EtOCH.sub.2, F), (M-3112, H, CH.sub.3, Cl, EtOCH.sub.2,
CF.sub.3), (M-3113, H, CH.sub.3, Cl, EtOCH.sub.2, Br), (M-3114, H,
CH.sub.3, Cl, EtOCH.sub.2, CH.sub.3), (M-3115, H, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, H), (M-3116, H, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, Cl), (M-3117, H, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, F), (M-3118, H, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-3119, H, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, Br), (M-3120, H, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-3121, H, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2, H), (M-3122, H, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-3123, H, CH.sub.3,
Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-3124, H, CH.sub.3,
Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.3, CF.sub.3), (M-3125, H,
CH.sub.3, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-3126,
H, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-3127, H, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2, H), (M-3128, H,
CH.sub.3, Cl, MeOCH.sub.2CH.sub.2, Cl), (M-3129, H, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, F), (M-3130, H, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-3131, H, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, Br), (M-3132, H, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-3133, H, CH.sub.3, Cl,
HOCH.sub.2, H), (M-3134, H, CH.sub.3, Cl, HOCH.sub.2, Cl), (M-3135,
H, CH.sub.3, Cl, HOCH.sub.2, F), (M-3136, H, CH.sub.3, Cl,
HOCH.sub.2, CF.sub.3), (M-3137, H, CH.sub.3, Cl, HOCH.sub.2, Br),
(M-3138, H, CH.sub.3, Cl, HOCH.sub.2, CH.sub.3), (M-3139, H,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2, H), (M-3140, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, Cl), (M-3141, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, F), (M-3142, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-3143, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, Br), (M-3144, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-3145, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2H), (M-3146, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-3147, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-3148, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3149, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-3150, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-3151, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3152, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-3153, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3154, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3155, H,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-3156, H,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-3157, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-3158, H, CH.sub.3,
Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-3159, H,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-3160, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-3161, H,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br),
(M-3162, H, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-3163, H,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-3164, H,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-3165, H,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-3106, H,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-3167, H, CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-3168, H, CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-3169, H, CH.sub.3, Cl, (Me).sub.2N, H), (M-3170, H,
CH.sub.3, Cl, (Me).sub.2N, Cl), (M-3171, H, CH.sub.3, Cl,
(Me).sub.2N, F), (M-3172, H, CH.sub.3, Cl, (Me).sub.2N, CF.sub.3),
(M-3173, H, CH.sub.3, Cl, (Me).sub.2N, Br), (M-3174, H, CH.sub.3,
Cl, (Me).sub.2N, CH.sub.3), (M-3175, H, CH.sub.3, Cl,
piperidin-4-yl-methyl, H), (M-3176, H, CH.sub.3, Cl,
piperidin-4-yl-methyl, Cl), (M-3177, H, CH.sub.3, Cl,
piperidin-4-yl-methyl, F), (M-3178, H, CH.sub.3, Cl,
piperidin-4-yl-methyl, CF.sub.3), (M-3179, H, CH.sub.3, Cl,
piperidin-4-yl-methyl, Br), (M-3180, H, CH.sub.3, Cl,
piperidin-4-yl-methyl, CH.sub.3), (M-3181, H, CH.sub.3, Cl,
cyclohexylmethyl, H), (M-3182, H, CH.sub.3, Cl, cyclohexylmethyl,
Cl), (M-3183, H, CH.sub.3, Cl, cyclohexylmethyl, F), (M-3184, H,
CH.sub.3, Cl, cyclohexylmethyl, CF.sub.3), (M-3185, H, CH.sub.3,
Cl, cyclohexylmethyl, Br), (M-3186, H, CH.sub.3, Cl,
cyclohexylmethyl, CH.sub.3), (M-3187, F, H, H, H, H), (M-3188, F,
H, H, H, Cl), (M-3189, MeO, F, H, H, CF.sub.3), (M-3190, MeO, F, F,
H, CF.sub.3), (M-3191, F, H, H, H, Br), (M-3192, F, H, H, H,
CH.sub.3), (M-3193, F, H, H, F, H), (M-3194, F, H, H, F, Cl),
(M-3195, F, H, H, F, F), (M-3196, F, H, H, F, CF.sub.3), (M-3197,
F, H, H, F, Br), (M-3198, F, H, H, F, CH.sub.3), (M-3199, F, H, H,
Cl, H), (M-3200, MeO, F, H, H, n-Pr), (M-3201, F, H, H, Cl, F),
(M-3202, F, H, H, Cl, CF.sub.3), (M-3203, F, H, H, Cl, Br),
(M-3204, F, H, H, Cl, CH.sub.3), (M-3205, F, H, H, CH.sub.3, H),
(M-3206, F, H, H, CH.sub.3, Cl), (M-3207, F, H, H, CH.sub.3, F),
(M-3208, F, H, H, CH.sub.3, CF.sub.3), (M-3209, F, H, H, CH.sub.3,
Br), (M-3210, F, H, H, CH.sub.3, CH.sub.3), (M-3211, F, H, H, Et,
H), (M-3212, F, H, H, Et, Cl), (M-3213, F, H, H, Et, F), (M-3214,
F, H, H, Et, CF.sub.3), (M-3215, F, H, H, Et, Br), (M-3216, F, H,
H, Et, CH.sub.3), (M-3217, F, H, H, n-Pr, H), (M-3218, F, H, H,
n-Pr, Cl), (M-3219, F, H, H, n-Pr, F), (M-3220, F, H, H, n-Pr,
CF.sub.3), (M-3221, F, H, H, n-Pr, Br), (M-3222, F, H, H, n-Pr,
CH.sub.3), (M-3223, F, H, H, c-Pr, H), (M-3224, F, H, H, c-Pr, Cl),
(M-3225, F, H, H, c-Pr, F), (M-3226, F, H, H, c-Pr, CF.sub.3),
(M-3227, F, H, H, c-Pr, Br), (M-3228, F, H, H, c-Pr, CH.sub.3),
(M-3229, F, H, H, i-Pr, H), (M-3230, F, H, H, i-Pr, Cl), (M-3231,
F, H, H, i-Pr, F), (M-3232, F, H, H, i-Pr, CF.sub.3), (M-3233, F,
H, H, i-Pr, Br), (M-3234, F, H, H, i-Pr, CH.sub.3), (M-3235, F, H,
H, n-Bu, H), (M-3236, F, H, H, n-Bu, Cl), (M-3237, F, H, H, n-Bu,
F), (M-3238, F, H, H, n-Bu, CF.sub.3), (M-3239, F, H, H, n-Bu, Br),
(M-3240, F, H, H, n-Bu, CH.sub.3), (M-3241, F, H, H, i-Bu, H),
(M-3242, F, H, H, i-Bu, Cl), (M-3243, F, H, H, i-Bu, F), (M-3244,
F, H, H, i-Bu, CF.sub.3), (M-3245, F, H, H, i-Bu, Br), (M-3246, F,
H, H, i-Bu, CH.sub.3), (M-3247, F, H, H, sec-Bu, H), (M-3248, F, H,
H, sec-Bu, Cl), (M-3249, F, H, H, sec-Bu, F), (M-3250, F, H, H,
sec-Bu, CF.sub.3), (M-3251, F, H, H, sec-Bu, Br), (M-3252, F, H, H,
sec-Bu, CH.sub.3), (M-3253, F, H, H, n-Pen, H), (M-3254, F, H, H,
n-Pen, Cl), (M-3255, F, H, H, n-Pen, F), (M-3256, F, H, H, n-Pen,
CF.sub.3), (M-3257, F, H, H, n-Pen, Br), (M-3258, F, H, H, n-Pen,
CH.sub.3), (M-3259, F, H, H, c-Pen, H), (M-3260, F, H, H, c-Pen,
Cl), (M-3261, F, H, H, c-Pen, F), (M-3262, F, H, H, c-Pen,
CF.sub.3), (M-3263, F, H, H, c-Pen, Br), (M-3264, F, H, H, c-Pen,
CH.sub.3), (M-3265, F, H, H, n-Hex, H), (M-3266, F, H, H, n-Hex,
Cl), (M-3267, F, H, H, n-Hex, F), (M-3268, F, H, H, n-Hex,
CF.sub.3), (M-3269, F, H, H, n-Hex, Br), (M-3270, F, H, H, n-Hex,
CH.sub.3), (M-3271, F, H, H, c-Hex, H), (M-3272, F, H, H, c-Hex,
Cl), (M-3273, F, H, H, c-Hex, F), (M-3274, F, H, H, c-Hex,
CF.sub.3), (M-3275, F, H, H, c-Hex, Br), (M-3276, F, H, H, c-Hex,
CH.sub.3), (M-3277, F, H, H, OH, H), (M-3278, F, H, H, OH, Cl),
(M-3279, F, H, H, OH, F), (M-3280, F, H, H, OH, CF.sub.3), (M-3281,
F, H, H, OH, Br), (M-3282, F, H, H, OH, CH.sub.3), (M-3283, F, H,
H, EtO, H), (M-3284, F, H, H, EtO, Cl), (M-3285, F, H, H, EtO, F),
(M-3286, F, H, H, EtO, CF.sub.3), (M-3287, F, H, H, EtO, Br),
(M-3288, F, H, H, EtO, CH.sub.3), (M-3289, F, H, H, n-PrO, H),
(M-3290, F, H, H, n-PrO, Cl), (M-3291, F, H, H, n-PrO, F), (M-3292,
F, H, H, n-PrO, CF
.sub.3), (M-3293, F, H, H, n-PrO, Br), (M-3294, F, H, H, n-PrO,
CH.sub.3), (M-3295, F, H, H, PhO, H), (M-3296, F, H, H, PhO, Cl),
(M-3297, F, H, H, PhO, F), (M-3298, F, H, H, PhO, CF.sub.3),
(M-3299, F, H, H, PhO, Br), (M-3300, F, H, H, PhO, CH.sub.3),
(M-3301, F, H, H, BnO, H), (M-3302, F, H, H, BnO, Cl), (M-3303, F,
H, H, BnO, F), (M-3304, F, H, H, BnO, CF.sub.3), (M-3305, F, H, H,
BnO, Br), (M-3306, F, H, H, BnO, CH.sub.3), (M-3307, F, H, H,
PhCH.sub.2CH.sub.2O, H), (M-3308, F, H, H, PhCH.sub.2CH.sub.2O,
Cl), (M-3309, F, H, H, PhCH.sub.2CH.sub.2O, F), (M-3310, F, H, H,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-3311, F, H, H,
PhCH.sub.2CH.sub.2O, Br), (M-3312, F, H, H, PhCH.sub.2CH.sub.2O,
CH.sub.3), (M-3313, MeO, H, H, CF.sub.3O, CH.sub.3), (M-3314, F, H,
H, CF.sub.3O, Cl), (M-3315, F, H, H, CF.sub.3O, F), (M-3316, F, H,
H, CF.sub.3O, CF.sub.3), (M-3317, F, H, H, CF.sub.3O, Br), (M-3318,
F, H, H, CF.sub.3O, CH.sub.3), (M-3319, F, H, H, Ph, H), (M-3320,
F, H, H, Ph, Cl), (M-3321, F, H, H, Ph, F), (M-3322, F, H, H, Ph,
CF.sub.3), (M-3323, F, H, H, Ph, Br), (M-3324, F, H, H, Ph,
CH.sub.3), (M-3325, F, H, H, 4-F-Ph, H), (M-3326, F, H, H, 4-F-Ph,
Cl), (M-3327, F, H, H, 4-F-Ph, F), (M-3328, F, H, H, 4-F-Ph,
CF.sub.3), (M-3329, F, H, H, 4-F-Ph, Br), (M-3330, F, H, H, 4-F-Ph,
CH.sub.3), (M-3331, F, H, H, 4-CF.sub.3-Ph, H), (M-3332, F, H, H,
4-CF.sub.3-Ph, Cl), (M-3333, F, H, H, 4-CF.sub.3-Ph, F), (M-3334,
F, H, H, 4-CF.sub.3-Ph, CF.sub.3), (M-3335, F, H, H, 4-CF.sub.3-Ph,
Br), (M-3336, F, H, H, 4-CF.sub.3-Ph, CH.sub.3), (M-3337, F, H, H,
4-(Me).sub.2N-Ph, H), (M-3338, F, H, H, 4-(Me).sub.2N-Ph, Cl),
(M-3339, F, H, H, 4-(Me).sub.2N-Ph, F), (M-3340, F, H, H,
4-(Me).sub.2N-Ph, CF.sub.3), (M-3341, F, H, H, 4-(Me).sub.2N-Ph,
Br), (M-3342, F, H, H, 4-(Me).sub.3N-Ph, CH.sub.3), (M-3343, F, H,
H, 4-OH-Ph, H), (M-3344, F, H, H, 4-OH-Ph, Cl), (M-3345, F, H, H,
4-OH-Ph, F), (M-3346, F, H, H, 4-OH-Ph, CF.sub.3), (M-3347, F, H,
H, 4-OH-Ph, Br), (M-3348, F, H, H, 4-OH-Ph, CH.sub.3), (M-3349, F,
H, H, 3,4-di-F-Ph, H), (M-3350, F, H, H, 3,4-di-F-Ph, Cl), (M-3351,
F, H, H, 3,4-di-F-Ph, F), (M-3352, F, H, H, 3,4-di-F-Ph, CF.sub.3),
(M-3353, F, H, H, 3,4-di-F-Ph, Br), (M-3354, F, H, H, 3,4-di-F-Ph,
CH.sub.3), (M-3355, F, H, H, 4-COOH-Ph, H), (M-3356, F, H, H,
4-COOH-Ph, Cl), (M-3357, F, H, H, 4-COOH-Ph, F), (M-3358, F, H, H,
4-COOH-Ph, CF.sub.3), (M-3359, F, H, H, 4-COOH-Ph, Br), (M-3360, F,
H, H, 4-COOH-Ph, CH.sub.3), (M-3361, F, H, H, Bo, H), (M-3362, F,
H, H, Bn, Cl), (M-3363, F, H, H, Bn, F), (M-3364, F, H, H, Bn,
CF.sub.3), (M-3365, F, H, H, Bu, Br), (M-3366, F, H, H, Bn,
CH.sub.3), (M-3367, F, H, H, 4-F-Bn, H), (M-3368, F, H, H, 4-F-Bn,
Cl), (M-3369, F, H, H, 4-F-Bn, F), (M-3370, F, H, H, 4-F-Bn,
CF.sub.3), (M-3371, F, H, H, 4-F-Bn, Br), (M-3372, F, H, H, 4-F-Bn,
CH.sub.3), (M-3373, F, H, H, 2-Py, H), (M-3374, F, H, H, 2-Py, Cl),
(M-3375, F, H, H, 2-Py, F), (M-3376, F, H, H, 2-Py, CF.sub.3),
(M-3377, F, H, H, 2-Py, Br), (M-3378, F, H, H, 2-Py, CH.sub.3),
(M-3379, F, H, H, 3-Py, H), (M-3380, F, H, H, 3-Py, Cl), (M-3381,
F, H, H, 3-Py, F), (M-3382, F, H, H, 3-Py, CF.sub.3), (M-3383, F,
H, H, 3-Py, Br), (M-3384, F, H, H, 3-Py, CH.sub.3), (M-3385, F, H,
H, 4-Py, H), (M-3386, F, H, H, 4-Py, Cl), (M-3387, F, H, H, 4-Py,
F), (M-3388, F, H, H, 4-Py, CF.sub.3), (M-3389, F, H, H, 4-Py, Br),
(M-3390, F, H, H, 4-Py, CH.sub.3), (M-3391, F, H, H, 2-Th, H),
(M-3392, F, H, H, 2-Th, Cl), (M-3393, F, H, H, 2-Th, F), (M-3394,
F, H, H, 2-Th, CF.sub.3), (M-3395, F, H, H, 2-Th, Br), (M-3396, F,
H, H, 2-Th, CH.sub.3), (M-3397, F, H, H, 3-Th, H), (M-3398, F, H,
H, 3-Th, Cl), (M-3399, F, H, H, 3-Th, F), (M-3400, F, H, H, 3-Th,
CF.sub.3), (M-3401, F, H, H, 3-Th, Br), (M-3402, F, H, H, 3-Th,
CH.sub.3), (M-3403, F, H, H, pyrrazol-2-yl, H), (M-3404, F, H, H,
pyrrazol-2-yl, Cl), (M-3405, F, H, H, pyrrazol-2-yl, F), (M-3406,
F, H, H, pyrrazol-2-yl, CF.sub.3), (M-3407, F, H, H, pyrrazol-2-yl,
Br), (M-3408, F, H, H, pyrrazol-2-yl, CH.sub.3), (M-3409, F, H, H,
pyrrazol-3-yl, H), (M-3410, F, H, H, pyrrazol-3-yl, Cl), (M-3411,
F, H, H, pyrrazol-3-yl, F), (M-3412, F, H, H, pyrrazol-3-yl,
CF.sub.3), (M-3413, F, H, H, pyrrazol-3-yl, Br), (M-3414, F, H, H,
pyrrazol-3-yl, CH.sub.3), (M-3415, F, H, H, pyrimidin-2-yl, H),
(M-3416, F, H, H, pyrimidin-2-yl, Cl), (M-3417, F, H, H,
pyrimidin-2-yl, F), (M-3418, F, H, H, pyrimidin-2-yl, CF.sub.3),
(M-3419, F, H, H, pyrimidin-2-yl, Br), (M-3420, F, H, H,
pyrimidin-2-yl, CH.sub.3), (M-3421, F, H, H, pyrimidin-4-yl, H),
(M-3422, F, H, H, pyrimidin-4-yl, Cl), (M-3423, F, H, H,
pyrimidin-4-yl, F), (M-3424, F, H, H, pyrimidin-4-yl, CF.sub.3),
(M-3425, F, H, H, pyrimidin-4-yl, Br), (M-3426, F, H, H,
pyrimidin-4-yl, CH.sub.3), (M-3427, F, H, H, pyrimidin-5-yl, PT),
(M-3428, F, H, H, pyrimidin-5-yl, Cl), (M-3429, F, H, H,
pyrimidin-5-yl, F), (M-3430, F, H, H, pyrimidin-5-yl, CF.sub.3),
(M-3431, F, H, H, pyrimidin-5-yl, Br), (M-3432, F, H, H,
pyrimidin-5-yl, CH.sub.3), (M-3433, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-3434, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-3435, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-3436, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3437, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2Br), (M-3438, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-3439, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3440, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-3441, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3442, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3443, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-3444, F, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-3445, F, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3446, F, H,
H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-3447, F,
H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3448,
F, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-3449, F, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
(Br), (M-3450, F, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-3451,
F, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-3452, F, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-3453, F, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3454,
F, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-3455, F, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-3456, F, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-3457, F, H, H, MeOCH.sub.2, H), (M-3458, F, H, H, MeOCH.sub.2,
Cl), (M-3459, F, H, H, MeOCH.sub.2, F), (M-3460, F, H, H,
MeOCH.sub.2, CF.sub.3), (M-3461, F, H, H, MeOCH.sub.2, Br),
(M-3462, F, H, H, MeOCH.sub.2, CH.sub.3), (M-3463, F, H, H,
EtOCH.sub.2, H), (M-3464, F, H, H, EtOCH.sub.2, Cl), (M-3465, F, H,
H, EtOCH.sub.2, F), (M-3466, F, H, H, EtOCH.sub.2, CF.sub.3),
(M-3467, F, H, H, EtOCH.sub.2, Br), (M-3468, F, H, H, EtOCH.sub.2,
CH.sub.3), (M-3469, F, H, H, EtOCH.sub.2CH.sub.2, H), (M-3470, F,
H, H, EtOCH.sub.2CH.sub.2, Cl), (M-3471, F, H, H,
EtOCH.sub.2CH.sub.2, F), (M-3472, F, H, H, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-3473, F, H, H, EtOCH.sub.2CH.sub.2, Br), (M-3474, F,
H, H, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-3475, F, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-3476, F, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-3477, F, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, V), (M-3478, F, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-3479, F, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-3480, F, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-3481, F, H, H,
MeOCH.sub.2CH.sub.2, H), (M-3482, F, H, H, MeOCH.sub.2CH.sub.2,
Cl), (M-3483, F, H, H, MeOCH.sub.2CH.sub.2, F), (M-3484, F, H, H,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-3485, F, H, H,
MeOCH.sub.2CH.sub.2, Br), (M-3486, F, H, H, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-3487, F, H, H, HOCH.sub.2, H), (M-3488, F, H, H,
HOCH.sub.2, Cl), (M-3489, F, H, H, HOCH.sub.2, F), (M-3490, F, H,
H, HOCH.sub.2, CF.sub.3), (M-3491, F, H, H, HOCH.sub.2, Br),
(M-3492, F, H, H, HOCH.sub.2, CH.sub.3), (M-3493, F, H, H,
HOCH.sub.2CH.sub.2, H), (M-3494, F, H, H, HOCH.sub.2CH.sub.2, Cl),
(M-3495, F, H, H, HOCH.sub.2CH.sub.2, F), (M-3496, F, H, H,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-3497, F, H, H,
HOCH.sub.2CH.sub.2, Br), (M-3498, F, H, H, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-3499, F, H, H, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-3500, F, H, H, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-3501, F, H,
H, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-3502, F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3503, F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-3504, F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-3505, F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3506 F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-3507, F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3508, F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2 CH.sub.2, CF.sub.3), (M-3509, F, H, B,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-3510, F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-3511, F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3512, F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-3513, F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3514, F, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3515, F,
H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-3516, F,
H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-3517, F, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-3518,
F, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-3519, F, H,
H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-3520, F, H, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-3521, F, H, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-3522, F, H, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-3523, F, H, H,
(Me).sub.2N, H), (M-3524, F, H, H, (Me).sub.2N, Cl), (M-3525, F, H,
H, (Me).sub.2N, F), (M-3526, F, H, H, (Me).sub.2N, CF.sub.3),
(M-3527, F, H, H, (Me).sub.2N, Br), (M-3528, F, H, H, (Me).sub.2N,
CH.sub.3), (M-3529, F, H, H, piperidin-4-yl-methyl, H), (M-3530, F,
H, H, piperidin-4-yl-methyl, Cl), (M-3531, F, H, H,
piperidin-4-yl-methyl, F), (M-3532, F, H, H, piperidin-4-yl-methyl,
CF.sub.3), (M-3533, F, H, H, piperidin-4-yl-methyl, Br), (M-3534,
F, H, H, piperidin-4-yl-methyl, CH.sub.3), (M-3535, F, H, H,
cyclohexylmethyl, H), (M-3536, F, H, H, cyclohexylmethyl, Cl),
(M-3537, F, H, H, cyclohexylmethyl, F), (M-3538, F, H, H,
cyclohexylmethyl, CF.sub.3), (M-3539, F, H, H, cyclohexylmethyl,
Br), (M-3540, F, H, H, cyclohexylmethyl, CH.sub.3), (M-3541, F, H,
F, H, H), (M-3542, F, H, F, H, Cl), (M-3543, F, H, F, H, F),
(M-3544, F, H, F, H, CF.sub.3), (M-3545, F, H, F, H, Br), (M-3546,
F, H, F, H, CH.sub.3), (M-3547, F, H, F, F, H), (M-3548, F, H, F,
F, Cl), (M-3549, F, H, F, F, F), (M-3550, F, H, F, F, CF.sub.3),
(M-3551, F, H, F, F, Br), (M-3552, F, H, F, F, CH.sub.3), (M-3553,
F, H, F, Cl, H), (M-3554, F, H, F, Cl, Cl), (M-3555, F, H, F, Cl,
F), (M-3556, F, H, F, Cl, CF.sub.3), (M-3557, F, H, F, Cl, Br),
(M-3558, F, H, F, Cl, CH.sub.3), (M-3559, F, H, F, CH.sub.3, H),
(M-3560, F, H, F, CH.sub.3, Cl), (M-3561, F, H, F, CH.sub.3, F),
(M-3562, F, H, F, CH.sub.3, CF.sub.3), (M-3663, F, H, F, CH.sub.3,
Br), (M-3564, F, H, F, CH.sub.3, CH.sub.3), (M-3565, F, H, F, Et,
H), (M-3566, F, H, F, Et, Cl), (M-3567, F, H, F, Et, P), (M-3568,
F, H, F, Et, CF.sub.3), (M-3569, F, H, F, Et, Br), (M-3570, F, H,
F, Et, CH.sub.3), (M-3571, F, H, F, n-Pr, H), (M-3572, F, H, F,
n-Pr, Cl), (M-3573, F, H, F, n-Pr, F), (M-3574, F, H, F, n-Pr,
CF.sub.3), (M-3575, F, H, F, n-Pr, Br), (M-3576, F, H, F, n-Pr,
CH.sub.3), (M-3577, F, H, F, c-Pr, H), (M-3578, F, H, F, c-Pr, Cl),
(M-3579, F, H, F, c-Pr, F), (M-3580, F, H, F, c-Pr, CF.sub.3),
(M-3581, F, H, F, c-Pr, Br), (M-3582, F, H, F, c-Pr, CH.sub.3),
(M-3583, F, H, F, i-Pr, H), (M-3584, F, H, F, i-Pr, Cl), (M-3585,
F, H, F, i-Pr, F), (M-3586, F, H, F, i-Pr, CF.sub.3), (M-3587, F,
H, F, i-Pr, Br), (M-3588, F, H, F, i-Pr, CH.sub.3), (M-3589, F, H,
F, n-Bu, H), (M-3590, F, H, F, n-Bu, Cl), (M-3591, F, H, F, n-Bu,
F), (M-3592, F, H, F, n-Bu, CF.sub.3), (M-3593, F, H, F, n-Bu, Br),
(M-3594, F, H, F, n-Bu, CH.sub.3), (M-3595, F, H, F, i-Bu, H),
(M-3596, F, H, F, i-Bu, Cl), (M-3597, F, H, F, i-Bu, F), (M-3598,
F, H, F, i-Bu, CF.sub.3), (M-3599, F, H, F, i-Bu, Br), (M-3600, F,
H, F, i-Bu, CH.sub.3), (M-3601, F, H, F, sec-Bu, H), (M-3602, F, H,
F, sec-Bu, Cl), (M-3603, F, H, F, sec-Bu, F), (M-3604, F, H, F,
sec-Bu, CF.sub.3), (M-3605, F, H, F, sec-Bu, Br), (M-3606, F, H, F,
sec-Bu, CH.sub.3), (M-3607, F, H, F, n-Pen, H), (M-3608, F, H, F,
n-Pen, Cl), (M-3609, F, H, F, n-Pen, F), (M-3610, F, H, F, n-Pen,
CF.sub.3), (M-3611, F, H, F, n-Pen, Br), (M-3612, F, H, F, n-Pen,
CH.sub.3), (M-3613, F, H, F, c-Pen, H), (M-3614, F, H, F, c-Pen,
Cl), (M-3615, F, H, F, c-Pen, F), (M-3616, F, H, F, c-Pen,
CF.sub.3), (M-3617, F, H, F, c-Pen, Br), (M-3618, F, H, F, c-Pen,
CH.sub.3), (M-3619, F, H, F, n-Hex, H), (M-3620, F, H, F, n-Hex,
Cl), (M-3621, F, H, F, n-Hex, F), (M-3622, F, H, F, n-Hex,
CF.sub.3), (M-3623, F, H, F, n-Hex, Br), (M-3624, F, H, F, n-Hex,
CH.sub.3), (M-3625, F, H, F, c-Hex, H), (M-3626, F, H, F, c-Hex,
Cl), (M-3627, F, H, F, c-Hex, F), (M-3628, F, H, F, c-Hex,
CF.sub.3), (M-3629, F, H, F, c-Hex, Br), (M-3630, F, H, F, c-Hex,
CH.sub.3), (M-3631, F, H, F, OH, H), (M-3632, F, H, F, OH, Cl),
(M-3633, F, H, F, OH, F), (M-3634, F, H, F, OH, CF.sub.3), (M-3635,
F, H, F, OH, Br), (M-3636, F, H, F, OH, CH.sub.3), (M-3637, F, H,
F, EtO, H), (M-3638, F, H, F, EtO, Cl), (M-3639, F, H, F, EtO, F),
(M-3640, F, H, F, EtO, CF.sub.3), (M-3641, F, H, F, EtO, Br),
(M-3642, F, H, F, EtO, CH.sub.3), (M-3643, F, H, F, n-PrO, H),
(M-3644, F, H, F, n-PrO, Cl), (M-3645, F, H, F, n-PrO, F), (M-3646,
F, H, F, n-PrO, CF.sub.3), (M-3647, F, H, F, n-PrO, Br), (M-3648,
F, H, P, n-PrO, CH.sub.3), (M-3649, F, H, F, PhO, H), (M-3650, F,
H, F, PhO, Cl), (M-3651, F, H, F, PhO, F), (M-3652, F, H, F, PhO,
CF.sub.3), (M-3653, F, H, F, PhO, Br), (M-3654, F, H, F, PhO,
CH.sub.3), (M-3655, F, H, F, BnO, H), (M-3656, F, H, F, BnO, Cl),
(M-3657, F, H, F, BnO, F), (M-3658, F, H, F, BnO, CF.sub.3),
(M-3659, F, H, F, BnO, Br), (M-3660, F, H, F, BnO, CH.sub.3),
(M-3661, F, H, F, PhCH.sub.2CH.sub.2O, H), (M-3662, F, H, F,
PhCH.sub.2CH.sub.2O, Cl), (M-3663, F, H, F, PhCH.sub.2CH.sub.2O,
F), (M-3664, F, H, F, PhCH.sub.2CH.sub.2O, CF.sub.3), (M-3665, F,
H, F, PhCH.sub.2CH.sub.2O, Br), (M-3666, F, H, F,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-3667, F, H, F, CF.sub.3O, H),
(M-3668, F, H, F, CF.sub.3O, Cl), (M-3669, F, H, F, CF.sub.3O, F),
(M-3670, F, H, F, CF.sub.3O, CF.sub.3), (M-3671, F, H, F,
CF.sub.3O, Br), (M-3672, F, H, F, CF.sub.3O, CH.sub.3), (M-3673, F,
H, F, Ph, H), (M-3674, F, H, F, Ph, Cl), (M-3675, F, H, F, Ph, F),
(M-3676, F, H, F, Ph, CF.sub.3), (M-3677, F, H, F, Ph, Br),
(M-3678, F, H, F, Ph, CH.sub.3), (M-3679, F, H, F, 4-F-Ph, H),
(M-3680, F, H, F, 4-F-Ph, Cl), (M-3681, F, H, F, 4-F-Ph, F),
(M-3682, F, H, F, 4-F-Ph, CF
.sub.3), (M-3683, F, H, F, 4-F-Ph, Br), (M-3684, F, H, F, 4-F-Ph,
CH.sub.3), (M-3685, F, H, F, 4-CF.sub.3-Ph, H), (M-3686, F, H, F,
4-CF.sub.3-Ph, Cl), (M-3687, F, H, F, 4-CF.sub.3-Ph, F), (M-3688,
F, H, F, 4-CF.sub.3-Ph, CF.sub.3), (M-3689, F, H, F, 4-CF.sub.3-Ph,
Br), (M-3690, F, H, F, 4-CF.sub.3-Ph, CH.sub.3), (M-3691, F, H, F,
4-(Me).sub.2N-Ph, H), (M-3692, F, H, F, 4-(Me).sub.2N-Ph, Cl),
(M-3693, F, H, F, 4-(Me).sub.2N-Ph, F), (M-3694, F, H, F,
4-(Me).sub.2N-Ph, CF.sub.3), (M-3695, F, H, F, 4-(Me).sub.2N-Ph,
Br), (M-3696, F, H, F, 4-(Me).sub.2N-Ph, CH.sub.3), (M-3697, F, H,
F, 4-OH-Ph, H), (M-3698, F, H, F, 4-OH-Ph, Cl), (M-3699, F, H, F,
4-OH-Ph, F), (M-3700, F, H, F, 4-OH-Ph, CF.sub.3), (M-3701, F, H,
F, 4-OH-Ph, Br), (M-3702, F, H, F, 4-OH-Ph, CH.sub.3), (M-3703, F,
H, F, 3,4-di-F-Ph, H), (M-3704, F, H, F, 3,4-di-F-Ph, Cl), (M-3705,
F, H, F, 3,4-di-F-Ph, F), (M-3706, F, H, F, 3,4-di-F-Ph, CF.sub.3),
(M-3707, F, H, F, 3,4-di-F-Ph, Br), (M-3708, F, H, F, 3,4-di-F-Ph,
CH.sub.3), (M-3709, F, H, F, 4-COOH-Ph, H), (M-3710, F, H, F,
4-COOH-Ph, Cl), (M-3711, F, H, F, 4-COOH-Ph, F), (M-3712, F, H, F,
4-COOH-Ph, CF.sub.3), (M-3713, F, H, F, 4-COOH-Ph, Br), (M-3714, F,
H, F, 4-COOH-Ph, CH.sub.3), (M-3715, F, H, F, Bn, H), (M-3716, F,
H, F, Bn, Cl), (M-3717, F, H, F, Bn, F), (M-3718, F, H, F, Bn,
CF.sub.3), (M-3719, F, H, F, Bn, Br), (M-3720, F, H, F, Bn,
CH.sub.3), (M-3721, F, H, F, 4-F-Bn, H), (M-3722, F, H, F, 4-F-Bn,
Cl), (M-3723, F, H, F, 4-F-Bn, F), (M-3724, F, H, F, 4-F-Bn,
CF.sub.3), (M-3725, F, H, F, 4-F-Bn, Br), (M-3726, F, H, F, 4-F-Bn,
CH.sub.3), (M-3727, F, H, F, 2-Py, H), (M-3728, F, H, F, 2-Py, Cl),
(M-3729, F, H, F, 2-Py, F), (M-3730, F, H, F, 2-Py, CF.sub.3),
(M-3731, F, H, F, 2-Py, Br), (M-3732, F, H, F, 2-Py, CH.sub.3),
(M-3733, F, H, F, 3-Py, H), (M-3734, F, H, F, 3-Py, Cl), (M-3735,
F, H, F, 3-Py, F), (M-3736, F, H, F, 3-Py, CF.sub.3), (M-3737, F,
H, F, 3-Py, Br), (M-3738, F, H, F, 3-Py, CH.sub.3), (M-3739, F, H,
F, 4-Py, H), (M-3740, F, H, F, 4-Py, Cl), (M-3741, F, H, F, 4-Py,
F), (M-3742, F, H, F, 4-Py, CF.sub.3), (M-3743, F, H, F, 4-Py, Br),
(M-3744, F, H, F, 4-Py, CH.sub.3), (M-3745, F, H, F, 2-Th, H),
(M-3746, F, H, F, 2-Th, Cl), (M-3747, F, H, F, 2-Th, F), (M-3748,
F, H, F, 2-Th, CF.sub.3), (M-3749, F, H, F, 2-Th, Br), (M-3750, F,
H, F, 2-Th, CH.sub.3), (M-3751, F, H, F, 3-Th, H), (M-3752, F, H,
F, 3-Th, Cl), (M-3753, F, H, F, 3-Th, F), (M-3754, F, H, F, 3-Th,
CF.sub.3), (M-3755, F, H, F, 3-Th, Br), (M-3756, F, H, F, 3-Th,
CH.sub.3), (M-3757, F, H, F, pyrrazol-2-yl, H), (M-3758, F, H, F,
pyrrazol-2-yl, Cl), (M-3759, F, H, F, pyrrazol-2-yl, F), (M-3760,
F, H, F, pyrrazol-2-yl, CF.sub.3), (M-3761, F, H, F, pyrrazol-2-yl,
Br), (M-3762, F, H, F, pyrrazol-2-yl, CH.sub.3), (M-3763, F, H, F,
pyrrazol-3-yl, H), (M-3764, F, H, F, pyrrazol-3-yl, Cl), (M-3765,
F, H, F, pyrrazol-3-yl, F), (M-3766, F, H, F, pyrrazol-3-yl,
CF.sub.3), (M-3767, F, H, F, pyrrazol-3-yl, Br), (M-3768, F, H, F,
pyrrazol-3-yl, CH.sub.3), (M-3769, F, H, F, pyrimidin-2-yl, H),
(M-3770, F, H, F, pyrimidin-2-yl, Cl), (M-3771, F, H, F,
pyrimidin-2-yl, F), (M-3772, F, h, F, pyrimidin-2-yl, CF.sub.3),
(M-3773, F, H, F, pyrimidin-2-yl, Br), (M-3774, F, H, F,
pyrimidin-2-yl, CH.sub.3), (M-3775, F, H, F, pyrimidin-4-yl, H),
(M-3776, F, H, F, pyrimidin-4-yl, Cl), (M-3777, F, H, F,
pyrimidin-4-yl, F), (M-3778, F, H, F, pyrimidin-4-yl, CF.sub.3),
(M-3779, F, H, F, pyrimidin-4-yl, Br), (M-3780, F, H, F,
pyrimidin-4-yl, CH.sub.3), (M-3781, F, H, F, pyrimidin-5-yl, h),
(M-3782, F, H, F, pyrimidin-5-yl, Cl), (M-3783, F, H, F,
pyrimidin-5-yl, F), (M-3784, F, H, F, pyrimidin-5-yl, CF.sub.3),
(M-3785, F, H, F, pyrimidin-5-yl, Br), (M-3786, F, H, F,
pyrimidin-5-yl, CH.sub.3), (M-3787, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-3788, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-3789, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-3790, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3791, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-3792, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-3793, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3794, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-3795, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3796, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3797, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-3798, F, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-3799, F, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3800, F, H,
F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-3801, F,
H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3802,
F, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-3803, F, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-3804, F, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.3), (M-3805,
F, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-3806, F, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2) Cl),
(M-3807, F, h, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3808,
F, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-3809, F, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-3810, F, h, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-3811, F, H, F, MeOCH.sub.2, H), (M-3812, F, H, F, MeOCH.sub.2,
Cl), (M-3813, F, H, F, MeOCH.sub.2, F), (M-3814, F, H, F,
MeOCH.sub.2, CF.sub.3), (M-3815, F, H, F, MeOCH.sub.2, Br),
(M-3816, F, H, F, MeOCH.sub.2, CH.sub.3), (M-3817, F, H, F,
EtOCH.sub.2, H), (M-3818, F, H, F, EtOCH.sub.2, Cl), (M-3819, F, H,
F, EtOCH.sub.2, F), (M-3820, F, H, F, EtOCH.sub.2, CF.sub.3),
(M-3821, F, H, F, EtOCH.sub.2, Br), (M-3822, F, H, F, EtOCH.sub.2,
CH.sub.3), (M-3823, F, H, F, EtOCH.sub.2CH.sub.2, H), (M-3824, F,
H, F, EtOCH.sub.2CH.sub.2, Cl), (M-3825, F, H, F,
EtOCH.sub.2CH.sub.2, F), (M-3826, F, H, F, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-3827, F, H, F, EtOCH.sub.2CH.sub.2, Br), (M-3828, F,
H, F, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-3829, F, H, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-3830, F, H, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-3831, F, H, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-3832, F, H, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-3833, F, H, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-3834, F, H, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-3835, F, H, F,
MeOCH.sub.2CH.sub.2, H), (M-3836, F, H, F, MeOCH.sub.2CH.sub.2,
Cl), (M-3837, F, H, F, MeOCH.sub.2CH.sub.2, F), (M-3838, F, H, F,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-3839, F, H, F,
MeOCH.sub.2CH.sub.2, Br), (M-3840, F, H, F, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-3841, F, H, F, HOCH.sub.2, H), (M-3842, F, H, F,
HOCH.sub.2, Cl), (M-3843, F, H, F, HOCH.sub.2, F), (M-3844, F, H,
F, HOCH.sub.2, CF.sub.3), (M-3845, F, H, F, HOCH.sub.2, Br),
(M-3846, F, H, F, HOCH.sub.2, CH.sub.3), (M-3847, F, H, F,
HOCH.sub.2CH.sub.2, H), (M-3848, F, H, F, HOCH.sub.2CH.sub.2, Cl),
(M-3849, F, H, F, HOCH.sub.2CH.sub.2, F), (M-3850, F, H, F,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-3851, F, H, F,
HOCH.sub.2CH.sub.2, Br), (M-3852, F, H, F, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-3853, F, H, F, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-3854, F, H, F, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-3855, F, H,
F, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-3856, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3857, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-3858, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-3859, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3860, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-3861, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3862, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3863, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-3864, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-3865, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-3866, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-3867, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-3868, F, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-3869, F,
H, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3, Br), (M-3870, F,
H, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-3871, F, H, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-3872,
F, H, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-3873, F, H,
F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-3874, F, H, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-3875, F, H, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-3876, F, H, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-3877, F, H, F,
(Me).sub.2N, H), (M-3878, F, H, F, (Me).sub.2N, Cl), (M-3879, F, H,
F, (Me).sub.2N, F), (M-3880, F, H, F, (Me).sub.2N, CF.sub.3),
(M-3881, F, H, F, (Me).sub.2N, Br), (M-3882, F, H, F, (Me).sub.2N,
CH.sub.3), (M-3883, F, H, F, piperidin-4-yl-methyl, H), (M-3884, F,
H, F, piperidin-4-yl-methyl, Cl), (M-3885, F, H, F,
piperidin-4-yl-methyl, F), (M-3886, F, H, F, piperidin-4-yl-methyl,
CF.sub.3), (M-3887, F, H, F, piperidin-4-yl-methyl, Br), (M-3888,
F, H, F, piperidin-4-yl-methyl, CH.sub.3), (M-3889, F, H, F,
cyclohexylmethyl, H), (M-3890, F, H, F, cyclohexylmethyl, Cl),
(M-3891, F, H, F, cyclohexylmethyl, F), (M-3892, F, H, F,
cyclohexylmethyl, CF.sub.3), (M-3893, F, H, F, cyclohexylmethyl,
Br), (M-3894, F, H, F, cyclohexylmethyl, CH.sub.3), (M-3895, F, H,
Cl, H, H), (M-3896, F, H, Cl, H, Cl), (M-3897, F, H, Cl, H, F),
(M-3898, F, H, Cl, H, CF.sub.3), (M-3899, F, H, Cl, H, Br),
(M-3900, F, H, Cl, H, CH.sub.3), (M-3901, F, H, Cl, F, H), (M-3902,
F, H, Cl, F, Cl), (M-3903, F, H, Cl, F, F), (M-3904, F, H, Cl, F,
CF.sub.3), (M-3905, F, H, Cl, F, Br), (M-3906, F, H, Cl, F,
CH.sub.3), (M-3907, F, H, Cl, Cl, H), (M-3908, F, H, Cl, Cl, Cl),
(M-3909, F, H, Cl, Cl, F), (M-3910, F, H, Cl, Cl, CF.sub.3),
(M-3911, F, H, Cl, Cl, Br), (M-3912, F, H, Cl, Cl, CH.sub.3),
(M-3913, F, H, Cl, CH.sub.3, H), (M-3914, F, H, Cl, CH.sub.3, Cl),
(M-3915, F, H, Cl, CH.sub.3, F), (M-3916, F, H, Cl, CH.sub.3,
CF.sub.3), (M-3917, F, H, Cl, CH.sub.3, Br), (M-3918, F, H, Cl,
CH.sub.3, CH.sub.3), (M-3919, F, H, Cl, Et, H), (M-3920, F, H, Cl,
Et, Cl), (M-3921, F, H, Cl, Et, F), (M-3922, F, H, Cl, Et,
CF.sub.3), (M-3923, F, H, Cl, Et, Br), (M-3924, F, H, Cl, Et,
CH.sub.3), (M-3925, F, H, Cl, n-Pr, H), (M-3926, F, H, Cl, n-Pr,
Cl), (M-3927, F, H, Cl, n-Pr, F), (M-3928, F, H, Cl, n-Pr,
CF.sub.3), (M-3929, F, H, Cl, n-Pr, Br), (M-3930, F, H, Cl, n-Pr,
CH.sub.3), (M-3931, F, H, Cl, c-Pr, H), (M-3932, F, H, Cl, c-Pr,
Cl), (M-3933, F, H, Cl, c-Pr, F), (M-3934, F, H, Cl, c-Pr,
CF.sub.3), (M-3935, F, H, Cl, c-Pr, Br), (M-3936, F, H, Cl, c-Pr,
CH.sub.3), (M-3937, F, H, Cl, i-Pr, H), (M-3938, F, H, Cl, i-Pr,
Cl), (M-3939, F, H, Cl, i-Pr, F), (M-3940, F, H, Cl, i-Pr,
CF.sub.3), (M-3941, F, H, Cl, i-Pr, Br), (M-3942, F, H, Cl, i-Pr,
CH.sub.3), (M-3943, F, H, Cl, n-Bu, H), (M-3944, F, H, Cl, n-Bu,
Cl), (M-3945, F, H, Cl, n-Bu, F), (M-3946, F, H, Cl, n-Bu,
CF.sub.3), (M-3947, F, H, Cl, n-Bu, Br), (M-3948, F, H, Cl, n-Bu,
CH.sub.3), (M-3949, F, H, Cl, i-Bu, H), (M-3950, F, H, Cl, i-Bu,
Cl), (M-3951, F, H, Cl, i-Bu, F), (M-3952, F, H, Cl, i-Bu,
CF.sub.3), (M-3953, F, H, Cl, i-Bu, Br), (M-3954, F, H, Cl, i-Bu,
CH.sub.3), (M-3955, F, H, Cl, sec-Bu, H), (M-3956, F, H, Cl,
sec-Bu, Cl), (M-3957, F, H, Cl, sec-Bu, F), (M-3958, F, H, Cl,
sec-Bu, CF.sub.3), (M-3959, F, H, Cl, sec-Bu, Br), (M-3960, F, H,
Cl, sec-Bu, CH.sub.3), (M-3961, F, H, Cl, n-Pen, H), (M-3962, F, H,
Cl, n-Pen, Cl), (M-3963, F, H, Cl, n-Fen, F), (M-3964, F, H, Cl,
n-Pen, CF.sub.3), (M-3965, F, H, Cl, n-Pen, Br), (M-3966, F, H, Cl,
n-Pen, CH.sub.3), (M-3967, F, H, Cl, c-Pen, H), (M-3968, F, H, Cl,
c-Pen, Cl), (M-3969, F, H, Cl, c-Pen, F), (M-3970, F, H, Cl, c-Pen,
CF.sub.3), (M-3971, F, H, Cl, c-Pen, Br), (M-3972, F, H, Cl, c-Pen,
CH.sub.3), (M-3973, F, H, Cl, n-Hex, H), (M-3974, F, H, Cl, n-Hex,
Cl), (M-3975, F, H, Cl, n-Hex, F), (M-3976, F, H, Cl, n-Hex,
CF.sub.3), (M-3977, F, H, Cl, n-Hex, Br), (M-3978, F, H, Cl, n-Hex,
CH.sub.3), (M-3979, F, H, Cl, c-Hex, H), (M-3980, F, H, Cl, c-Hex,
Cl), (M-3981, F, H, Cl, c-Hex, F), (M-3982, F, H, Cl, c-Hex,
CF.sub.3), (M-3983, F, H, Cl, c-Hex, Br), (M-3984, F, H, Cl, c-Hex,
CH.sub.3), (M-3985, F, H, Cl, OH, H), (M-3986, F, H, Cl, OH, Cl),
(M-3987, F, H, Cl, OH, F), (M-3988, F, H, Cl, OH, CF.sub.3),
(M-3989, F, H, Cl, OH, Br), (M-3990, F, H, Cl, OH, CH.sub.3),
(M-3991, F, H, Cl, EtO, H), (M-3992, F, H, Cl, EtO, Cl), (M-3993,
F, H, Cl, EtO, F), (M-3994, F, H, Cl, EtO, CF.sub.3), (M-3995, F,
H, Cl, EtO, Br), (M-3996, F, H, Cl, EtO, CH.sub.3), (M-3997, F, H,
Cl, n-PrO, H), (M-3998, F, H, Cl, n-PrO, Cl), (M-3999, F, H, Cl,
n-PrO, F), (M-4000, F, H, Cl, n-PrO, CF.sub.3), (M-4001, F, H, Cl,
n-PrO, Br), (M-4002, F, H, Cl, n-PrO, CH.sub.3), (M-4003, F, H, Cl,
PhO, H), (M-4004, F, H, Cl, PhO, Cl), (M-4005, F, H, Cl, PhO, F),
(M-4006, F, H, Cl, PhO, CF.sub.3), (M-4007, F, H, Cl, PhO, Br),
(M-4008, F, H, Cl, PhO, CH.sub.3), (M-4009, F, H, Cl, BnO, H),
(M-4010, F, H, Cl, BnO, Cl), (M-4011, F, H, Cl, BnO, F), (M-4012,
F, H, Cl, BnO, CF.sub.3), (M-4013, F, H, Cl, BnO, Br), (M-4014, F,
H, Cl, BnO, CH.sub.3), (M-4015, F, H, Cl, PhCH.sub.2CH.sub.2O, H),
(M-4016, F, H, Cl, PhCH.sub.2CH.sub.2O, Cl), (M-4017, F, H, Cl,
PhCH.sub.2CH.sub.2O, F), (M-4018, F, H, Cl, PhCH.sub.2CH.sub.2O,
CF.sub.3), (M-4019, F, H, Cl, PhCH.sub.2CH.sub.2O, Br), (M-4020, F,
H, Cl, PhCH.sub.2CH.sub.2O, CH.sub.3), (M-4021, F, H, Cl,
CF.sub.3O, H), (M-4022, F, H, Cl, CF.sub.3O, Cl), (M-4023, F, H,
CJ, CF.sub.3O, F), (M-4024, F, H, Cl, CF.sub.3O, CF.sub.3),
(M-4025, F, H, Cl, CF.sub.3O, Br), (M-4026, F, H, Cl, CF.sub.3O,
CH.sub.3), (M-4027, F, H, Cl, Ph, H), (M-4028, F, H, Cl, Ph, Cl),
(M-4029, F, H, Cl, Ph, F), (M-4030, F, H, Cl, Ph, CF.sub.3),
(M-4031, F, H, Cl, Ph, Br), (M-4032, F, H, Cl, Ph, CH.sub.3),
(M-4033, F, H, Cl, 4-F-Ph, H), (M-4034, F, H, Cl, 4-F-Ph, Cl),
(M-4035, F, H, Cl, 4-F-Ph, F), (M-4036, F, H, Cl, 4-F-Ph,
CF.sub.3), (M-4037, F, H, Cl, 4-F-Ph, Br), (M-4038, F, H, Cl,
4-F-Ph, CH.sub.3), (M-4039, F, H, Cl, 4-CF.sub.3-Ph, H), (M-4040,
F, H, Cl, 4-CF.sub.3-Ph, Cl), (M-4041, F, H, Cl, 4-CF.sub.3-Ph, F),
(M-4042, F, H, Cl, 4-CF.sub.3-Ph, CF.sub.3), (M-4043, F, H, Cl,
4-CF.sub.3-Ph, Br), (M-4044, F, H, Cl, 4-CF.sub.3-Ph, CH.sub.3),
(M-4045, F, H, Cl, 4-(Me).sub.2N-Ph, H), (M-4046, F, H, Cl,
4-(Me).sub.2N-Ph, Cl), (M-4047, F, H, Cl, 4-(Me).sub.2N-Ph, F),
(M-4048, F, H, Cl, 4-(Me).sub.2N-Ph, CF.sub.3), (M-4049, F, H, Cl,
4-(Me).sub.2N-Ph, Br), (M-4050, F, H, Cl, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-4051, F, H, Cl, 4-OH-Ph, H), (M-4052, F, H, Cl,
4-OH-Ph, Cl), (M-4053, F, H, Cl, 4-OH-Ph, F), (M-4054, F, H, Cl,
4-OH-Ph, CF.sub.3), (M-4055, F, H, Cl, 4-OH-Ph, Br), (M-4056, F, H,
Cl, 4-OH-Ph, CH.sub.3), (M-4057, F, H, Cl, 3,4-di-F-Ph, H),
(M-4058, F, H, Cl, 3,4-di-F-Ph, Cl), (M-4059, F, H, Cl,
3,4-di-F-Ph, F), (M-4060, F, H, Cl, 3,4-di-F-Ph, CF.sub.3),
(M-4061, F, H, Cl, 3,4-di-F-Ph, Br), (M-4062, F, H, Cl,
3,4-di-F-Ph, CH
.sub.3), (M-4063, F, H, Cl, 4-COOH-Ph, H), (M-4064, F, H, Cl,
4-COOH-Ph, Cl), (M-4065, F, H, Cl, 4-COOH-Ph, F), (M-4066, F, H,
Cl, 4-COOH-Ph, CF.sub.3), (M-4067, F, H, Cl, 4-COOH-Ph, Br),
(M-4068, F, H, Cl, 4-COOH-Ph, CH.sub.3), (M-4069, F, H, Cl, Bn, H),
(M-4070, F, H, Cl, Bn, Cl), (M-4071, F, H, Cl, Bn, F), (M-4072, F,
H, Cl, Bn, CF.sub.3), (M-4073, F, H, Cl, Bn, Br), (M-4074, F, H,
Cl, Bn, CH.sub.3), (M-4075, F, H, Cl, 4-F-Bn, H), (M-4076, F, hi,
Cl, 4-F-Bn, Cl), (M-4077, F, H, Cl, 4-F-Bn, F), (M-4078, F, H, Cl,
4-F-Bn, CF.sub.3), (M-4079, F, H, Cl, 4-F-Bn, Br), (M-4080, F, H,
Cl, 4-F-Bn, CH.sub.3), (M-4081, F, H, Cl, 2-Py, H), (M-4082, F, H,
Cl, 2-Py, Cl), (M-4083, F, H, Cl, 2-Py, F), (M-4084, F, H, Cl,
2-Py, CF.sub.3), (M-4085, F, H, Cl, 2-Py, Br), (M-4086, F, H, Cl,
2-Py, CH.sub.3), (M-4087, F, H, Cl, 3-Py, H), (M-4088, F, H, Cl,
3-Py, Cl), (M-4089, F, H, Cl, 3-Py, F), (M-4090, F, H, Cl, 3-Py,
CF.sub.3), (M-4091, F, H, Cl, 3-Py, Br), (M-4092, F, H, Cl, 3-Py,
CH.sub.3), (M-4093, F, H, Cl, 4-Py, H), (M-4094, F, H, Cl, 4-Py,
Cl), (M-4095, F, H, Cl, 4-Py, F), (M-4096, F, H, Cl, 4-Py,
CF.sub.3), (M-4097, F, H, Cl, 4-Py, Br), (M-4098, F, H, Cl, 4-Py,
CH.sub.3), (M-4099, F, H, Cl, 2-Th, H), (M-4100, F, H, Cl, 2-Th,
Cl), (M-4101, F, H, Cl, 2-Th, F), (M-4102, F, H, Cl, 2-Th,
CF.sub.3), (M-4103, F, H, Cl, 2-Th, Br), (M-4104, F, H, Cl, 2-Th,
CH.sub.3), (M-4105, F, H, Cl, 3-Th, H), (M-4106, F, H, Cl, 3-Th,
Cl), (M-4107, F, H, Cl, 3-Th, F), (M-4108, F, H, Cl, 3-Th,
CF.sub.3), (M-4109, F, H, Cl, 3-Th, Br), (M-4110, F, H, Cl, 3-Th,
CH.sub.3), (M-4111, F, H, Cl, pyrrazol-2-yl, H), (M-4112, F, H, Cl,
pyrrazol-2-yl, Cl), (M-4113, F, H, Cl, pyrrazol-2-yl, F), (M-4114,
F, H, Cl, pyrrazol-2-yl, CF.sub.3), (M-4115, F, H, Cl,
pyrrazol-2-yl, Br), (M-4116, F, H, Cl, pyrrazol-2-yl, CH.sub.3),
(M-4117, F, H, Cl, pyrrazol-3-yl, H), (M-4118, F, H, Cl,
pyrrazol-3-yl, Cl), (M-4119, F, H, Cl, pyrrazol-3-yl, F), (M-4120,
F, H, Cl, pyrrazol-3-yl, CF.sub.3), (M-4121, F, H, Cl,
pyrrazol-3-yl, Br), (M-4122, F, H, Cl, pyrrazol-3-yl, CH.sub.3),
(M-4123, F, H, Cl, pyrimidin-2-yl, H), (M-4124, F, H, Cl,
pyrimidin-2-yl, Cl), (M-4125, F, H, Cl, pyrimidin-2-yl, F),
(M-4126, F, H, Cl, pyrimidin-2-yl, CF.sub.3), (M-4127, F, H, Cl,
pyrimidin-2-yl, Br), (M-4128, F, H, Cl, pyrimidin-2-yl, CH.sub.3),
(M-4129, F, H, Cl, pyrimidin-4-yl, H), (M-4130, F, H, Cl,
pyrimidin-4-yl, Cl), (M-4131, F, H, Cl, pyrimidin-4-yl, F),
(M-4132, F, H, Cl, pyrimidin-4-yl, CF.sub.3), (M-4133, F, H, Cl,
pyrimidin-4-yl, Br), (M-4134, F, H, Cl, pyrimidin-4-yl, CH.sub.3),
(M-4135, F, H, Cl, pyrimidin-5-yl, H), (M-4136, F, H, Cl,
pyrimidin-5-yl, Cl), (M-4137, F, H, Cl, pyrimidin-5-yl, F),
(M-4138, F, H, Cl, pyrimidin-5-yl, CF.sub.3), (M-4139, F, H, Cl,
pyrimidin-5-yl, Br), (M-4140, F, H, Cl, pyrimidin-5-yl, CH.sub.3),
(M-4141, F, H, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-4142, F, H,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-4143, F, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-4144, F, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4145, F, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-4146, F, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-4147, F, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-4148, F, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-4149, F, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4150, F, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4151, F, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-4152, F, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4153, F, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-4154, F, H,
Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.3, Cl), (M-4155, F,
H, Cl, (Me).sub.3NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4156,
F, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-4157, F, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-4158, F, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-4159, F,
H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2C.sub.2CH.sub.2CH.sub.2, H),
(M-4160, F, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-4161, F, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4162,
F, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-4163, F, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-4164, F, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-4165, F, H, Cl, MeOCH.sub.2, H), (M-4166,
[0159] F, H, Cl, MeOCH.sub.2, Cl), (M-4167, F, H, Cl, MeOCH.sub.2,
F), (M-4168, F, H, Cl, MeOCH.sub.2, CF.sub.3), (M-4169, F, H, Cl,
MeOCH.sub.2, Br), (M-4170, F, H, Cl, MeOCH.sub.2, CH.sub.3),
(M-4171, F, H, Cl, EtOCH.sub.2, H), (M-4172, F, H, Cl, EtOCH.sub.2,
Cl), (M-4173, F, H, Cl, EtOCH.sub.2, F), (M-4174, F, H, Cl,
EtOCH.sub.2, CF.sub.3), (M-4175, F, H, Cl, EtOCH.sub.2, Br),
(M-4176, F, H, Cl, EtOCH.sub.2, CH.sub.3), (M-4177, F, H, Cl,
EtOCH.sub.2CH.sub.3, H), (M-4178, F, H, Cl, EtOCH.sub.2CH.sub.2,
Cl), (M-4179, F, H, Cl, EtOCH.sub.2CH.sub.2, F), (M-4180, F, H, Cl,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-4181, F, H, Cl,
EtOCH.sub.2CH.sub.2, Br), (M-4182, F, H, Cl, EtOCH.sub.2CH.sub.2,
CH.sub.3), (M-4183, F, H, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
H), (M-4184, F, H, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-4185, F, H, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-4186, F, H, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-4187, F, H, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-4188, F, H, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-4189, F, H, Cl, MeOCH.sub.2CH.sub.2, H), (M-4190, F, H, Cl,
MeOCH.sub.2CH.sub.2, Cl), (M-4191, F, H, Cl, MeOCH.sub.2CH.sub.2,
F), (M-4192, F, H, Cl, MeOCH.sub.2CH.sub.2, CF.sub.3), (M-4193, F,
H, Cl, MeOCH.sub.2CH.sub.2, Br), (M-4194, F, H, Cl,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-4195, F, H, Cl, HOCH.sub.2, H),
(M-4196, F, H, Cl, HOCH.sub.2, Cl), (M-4197, F, H, Cl, HOCH.sub.2,
F), (M-4198, F, H, Cl, HOCH.sub.2, CH.sub.3), (M-4199, F, H, Cl,
HOCH.sub.2, Br), (M-4200, F, H, Cl, HOCH.sub.2, CH.sub.3), (M-4201,
F, H, Cl, HOCH.sub.2CH.sub.2, H), (M-4202, F, H, Cl,
HOCH.sub.2CH.sub.2, Cl), (M-4203, F, H, Cl, HOCH.sub.2CH.sub.2, F),
(M-4204, F, H, Cl, HOCH.sub.2CH.sub.2, CF.sub.3), (M-4205, F, H,
Cl, HOCH.sub.2CH.sub.2, Br), (M-4206, F, H, Cl, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-4207, F, H, Cl, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-4208, F, H, Cl, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-4209, F, H,
Cl, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-4210, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4211, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-4212, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4213, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-4214, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-4215, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4216, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4217, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-4218, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4219, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-4220, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-4221, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4222, F, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-4223, F, H,
Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-4224, F, H,
Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4225,
F, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-4226, F, H,
Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-4227, F, H, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-4228, F, H, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-4229, F, H, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-4230, F, H, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-4231, F, H, Cl,
(Me).sub.2N, H), (M-4232, F, H, Cl, (Me).sub.2N, Cl), (M-4233, F,
H, Cl, (Me).sub.2N, F), (M-4234, F, H, Cl, (Me).sub.2N, CF.sub.3),
(M-4235, F, H, Cl, (Me).sub.2N, Br), (M-4236, F, H, Cl,
(Me).sub.2N, CH.sub.3), (M-4237, F, H, Cl, piperidin-4-yl-methyl,
H), (M-4238, F, H, Cl, piperidin-4-yl-methyl, Cl), (M-4239, F, H,
Cl, piperidin-4-yl-methyl, F), (M-4240, F, H, Cl,
piperidin-4-yl-methyl, CF.sub.3), (M-4241, F, H, Cl,
piperidin-4-yl-methyl, Br), (M-4242, F, H, Cl,
piperidin-4-yl-methyl, CH.sub.3), (M-4243, F, H, Cl,
cyclohexylmethyl, H), (M-4244, F, H, Cl, cyclohexylmethyl, Cl),
(M-4245, F, H, Cl, cyclohexylmethyl, F), (M-4246, F, H, Cl,
cyclohexylmethyl, CF.sub.3), (M-4247, F, H, Cl, cyclohexylmethyl,
Br), (M-4248, F, H, Cl, cyclohexylmethyl, CH.sub.3), (M-4249, F, F,
H, H, H), (M-4250, F, F, H, H, Cl), (M-4251, F, F, H, H, F),
(M-4252, F, F, H, H, CF.sub.3), (M-4253, F, F, H, H, Br), (M-4254,
F, F, H, H, CH.sub.3), (M-4255, F, F, H, F, H), (M-4256, F, F, H,
F, Cl), (M-4257, F, F, H, F, F), (M-4258, F, F, H, F, CF.sub.3),
(M-4259, F, F, H, F, Br), (M-4260, F, F, H, F, CH.sub.3), (M-4261,
F, F, H, Cl, H), (M-4262, F, F, H, Cl, Cl), (M-4263, F, F, H, Cl,
F), (M-4264, F, F, H, Cl, CF.sub.3), (M-4265, F, F, H, Cl, Br),
(M-4266, F, F, H, Cl, CH.sub.3), (M-4267, F, F, H, CH.sub.3, H),
(M-4268, F, F, H, CH.sub.3, Cl), (M-4269, F, F, H, CH.sub.3, F),
(M-4270, F, F, H, CH.sub.3, CF.sub.3), (M-4271, F, F, H, CH.sub.3,
Br), (M-4272, F, F, H, CH.sub.3, CH.sub.3), (M-4273, F, F, H, Et,
H), (M-4274, F, F, H, Et, Cl), (M-4275, F, F, H, Et, F), (M-4276,
F, F, H, Et, CF.sub.3), (M-4277, F, F, H, Et, Br), (M-4278, F, F,
H, Et, CH.sub.3), (M-4279, F, F, H, n-Pr, H), (M-4280, F, F, H,
n-Pr, Cl), (M-4281, F, F, H, n-Pr, F), (M-4282, F, F, H, n-Pr,
CF.sub.3), (M-4283, F, F, H, n-Pr, Br), (M-4284, F, F, H, n-Pr,
CH.sub.3), (M-4285, F, F, H, c-Pr, H), (M-4286, F, F, H, c-Pr, Cl),
(M-4287, F, F, H, c-Pr, F), (M-4288, F, F, H, c-Pr, CF.sub.3),
(M-4289, F, F, H, c-Pr, Br), (M-4290, F, F, H, c-Pr, CH.sub.3),
(M-4291, F, F, H, i-Pr, H), (M-4292, F, F, H, i-Pr, Cl), (M-4293,
F, F, H, i-Pr, F), (M-4294, F, F, H, i-Pr, CF.sub.3), (M-4295, F,
F, H, i-Pr, Br), (M-4296, F, F, H, i-Pr, CH.sub.3), (M-4297, F, F,
H, n-Bu, H), (M-4298, F, F, H, n-Bu, Cl), (M-4299, F, F, H, n-Bu,
F), (M-4300, F, F, H, n-Bu, CF.sub.3), (M-4301, F, F, H, n-Bu, Br),
(M-4302, F, F, H, n-Bu, CH.sub.3), (M-4303, F, F, H, i-Bu, H),
(M-4304, F, F, H, i-Bu, Cl), (M-4305, F, F, H, i-Bu, F), (M-4306,
F, F, H, i-Bu, CF.sub.3), (M-4307, F, F, H, i-Bu, Br), (M-4308, F,
F, H, i-Bu, CH.sub.3), (M-4309, F, F, H, sec-Bu, H), (M-4310, F, F,
H, sec-Bu, Cl), (M-4311, F, F, H, sec-Bu, F), (M-4312, F, F, H,
sec-Bu, CF.sub.3), (M-4313, F, F, H, sec-Bu, Br), (M-4314, F, F, H,
sec-Bu, CH.sub.3), (M-4315, F, F, H, n-Pen, H), (M-4316, F, F, H,
n-Pen, Cl), (M-4317, F, F, H, n-Pen, F), (M-4318, F, F, H, n-Pen,
CF.sub.3), (M-4319, F, F, H, n-Pen, Br), (M-4320, F, F, H, n-Pen,
CH.sub.3), (M-4321, F, F, H, c-Pen, H), (M-4322, F, F, H, c-Pen,
Cl), (M-4323, F, F, H, c-Pen, F), (M-4324, F, F, H, c-Pen,
CF.sub.3), (M-4325, F, F, H, c-Pen, Br), (M-4326, F, F, H, c-Pen,
CH.sub.3), (M-4327, F, F, H, n-Hex, H), (M-4328, F, F, H, n-Hex,
Cl), (M-4329, F, F, H, n-Hex, F), (M-4330, F, F, H, n-Hex,
CF.sub.3), (M-4331, F, F, H, n-Hex, Br), (M-4332, F, F, H, n-Hex,
CH.sub.3), (M-4333, F, F, H, c-Hex, H), (M-4334, F, F, H, c-Hex,
Cl), (M-4335, F, F, H, c-Hex, F), (M-4336, F, F, H, C-Hex,
CF.sub.3), (M-4337, F, F, H, c-Hex, Br), (M-4338, F, F, H, c-Hex,
CH.sub.3), (M-4339, F, F, H, OH, H), (M-4340, F, F, H, OH, Cl),
(M-4341, F, F, H, OH, F), (M-4342, F, F, H, OH, CF.sub.3), (M-4343,
F, F, H, OH, Br), (M-4344, F, F, H, OH, CH.sub.3), (M-4345, F, F,
H, EtO, H), (M-4346, F, F, H, EtO, Cl), (M-4347, F, F, H, EtO, F),
(M-4348, F, F, H, EtO, CF.sub.3), (M-4349, F, F, H, EtO, Br),
(M-4350, F, F, H, EtO, CH.sub.3), (M-4351, F, F, H, n-PrO, H),
(M-4352, F, F, H, n-PrO, Cl), (M-4363, F, F, H, n-PrO, F), (M-4354,
F, F, H, n-PrO, CF.sub.3), (M-4355, F, F, H, n-PrO, Br), (M-4356,
F, F, H, n-PrO, CH.sub.3), (M-4357, F, F, H, PhO, H), (M-4358, F,
F, H, PhO, Cl), (M-4359, F, F, H, PhO, F), (M-4360, F, F, H, PhO,
CF.sub.3), (M-4361, F, F, H, PhO, Br), (M-4362, F, F, H, PhO,
CH.sub.3), (M-4363, F, F, H, BnO, H), (M-4364, F, F, H, BnO, Cl),
(M-4365, F, F, H, BnO, F), (M-4366, F, F, H, BnO, CF.sub.3),
(M-4367, F, F, H, BnO, Br), (M-4368, F, F, H, BnO, CH.sub.3),
(M-4369, F, F, H, PhCH.sub.2CH.sub.2O, H), (M-4370, F, F, H,
PhCH.sub.2CH.sub.2, Cl), (M-4371, F, F, H, PhCH.sub.2CH.sub.2O, F),
(M-4372, F, F, H, PhCH.sub.2CH.sub.2O, CF.sub.3), (M-4373, F, F, H,
PhCH.sub.2CH.sub.2O, Br), (M-4374, F, F, H, PhCH.sub.2CH.sub.2O,
CH.sub.3), (M-4375, F, F, H, CF.sub.3O, H), (M-4376, F, F, H,
CF.sub.3O, Cl), (M-4377, F, P, H, CF.sub.3O, F), (M-4378, F, F, H,
CF.sub.3O, CF.sub.3), (M-4379, F, F, H, CF.sub.3O, Br), (M-4380, F,
F, H, CF.sub.3O, CH.sub.3), (M-4381, F, F, H, Ph, H), (M-4382, F,
F, H, Ph, Cl), (M-4383, F, F, H, Ph, F), (M-4384, F, F, H, Ph,
CF.sub.3), (M-4385, F, F, H, Ph, Br), (M-4386, F, F, H, Ph,
CH.sub.3), (M-4387, F, F, H, 4-F-Ph, H), (M-4388, F, F, H, 4-F-Ph,
Cl), (M-4389, F, F, H, 4-F-Ph, F), (M-4390, F, F, H, 4-F-Ph,
CF.sub.3), (M-4391, F, F, H, 4-F-Ph, Br), (M-4392, F, F, H, 4-F-Ph,
CH.sub.3), (M-4393, F, F, H, 4-CF.sub.3-Ph, H), (M-4394, F, F, H,
4-CF.sub.3-Ph, Cl), (M-4395, F, F, H, 4-CF.sub.3-Ph, F), (M-4396,
F, F, H, 4-CF.sub.3-Ph, CF.sub.3), <M-4397, F, F, H,
4-CF.sub.3-Ph, Br), (M-4398, F, F, H, 4-CF.sub.3-Ph, CH.sub.3),
(M-4399, F, F, H, 4-(Me).sub.2N-Ph, H), (M-4400, F, F, H,
4-(Me).sub.2N-Ph, Cl), (M-4401, F, F, H, 4-(Me).sub.2N-Ph, F),
(M-4402, F, F, H, 4-(Me).sub.2N-Ph, CF.sub.3), (M-4403, F, F, H,
4-(Me).sub.2N-Ph, Br), (M-4404, F, F, H, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-4405, F, F, H, 4-OH-Ph, H), (M-4406, F, F, H,
4-OH-Ph, Cl), (M-4407, F, F, H, 4-OH-Ph, F), (M-4408, F, F, H,
4-OH-Ph, CF.sub.3), (M-4409, F, F, H, 4-OH-Ph, Br), (M-4410, F, F,
H, 4-OH-Ph, CH.sub.3), (M-4411, F, F, H, 3,4-di-F-Ph, H), (M-4412,
F, F, H, 3,4-di-F-Ph, Cl), (M-4413, F, F, H, 3,4-di-F-Ph, F),
(M-4414, F, F, H, 3,4-di-F-Ph, CF.sub.3), (M-4415, F, F, H,
3,4-di-F-Ph, Br), (M-4416, F, F, H, 3,4-di-R-Ph, CH.sub.3),
(M-4417, F, F, H, 4-COOH-Ph, H), (M-4418, F, F, H, 4-COOH-Ph, Cl),
(M-4419, F, F, H, 4-COOH-Ph, F), (M-4420, F, F, H, 4-COOH-Ph,
CF.sub.3), (M-4421, F, F, H, 4-COOH-Ph, Br), (M-4422, F, F, H,
4-COOH-Ph, CH.sub.3), (M-4423, F, F, H, Bn, H), (M-4424, F, F, H,
Bn, Cl), (M-4425, F, F, H, Bn, F), (M-4426, F, F, H, Bn, CF.sub.3),
(M-4427, F, F, H, Bn, Br), (M-4428, F, F, H, Bn, CH.sub.3),
(M-4429, F, F, H, 4-F-Bn, H), (M-4430, F, F, H, 4-F-Bn, Cl),
(M-4431, F, F, H, 4-F-Bn, F), (M-4432, F, F, H, 4-F-Bn, CF.sub.3),
(M-4433, F, F, H, 4-F-Bn, Br), (M-4434, F, F, H, 4-F-Bn, CH.sub.3),
(M-4435, F, F, H, 2-Py, H), (M-4436, F, F, H, 2-Py, Cl), (M-4437,
F, F, H, 2-Py, F), (M-4438, F, F, H, 2-Py, CF.sub.3), (M-4439, F,
F, H, 2-Py, Br), (M-4440, F, F, H, 2-Py, CH.sub.3), (M-4441, F, F,
H, 3-Py, H), (M-4442, F, F, H, 3-Py, Cl), (M-4443, F, F, H, 3-Py,
F), (M-4444, F, F, H, 3-Py, CF.sub.3), (M-4445, F, F, H, 3-Py, Br),
(M-4446, F, F, H, 3-Py, CH.sub.3), (M-4447, F, F, H, 4-Py, H),
(M-4448, F, F, H, 4-Py, Cl), (M-4449, F, F, H, 4-Py, F), (M-4450,
F, F, H, 4-Py, CF.sub.3), (M-4451, F, F, H, 4-Py, Br), (M-4452, F,
F, H, 4-Py, CH.sub.3), (M-4453, F, F, H, 2-Th, H), (M-4454, F, F,
H, 2-Th, Cl), (M-4455, F, F, H, 2-Th, F), (M-4456, F, F, H, 2-Th,
CF.sub.3), (M-4457, F, F, H, 2-Th, Br), (M-4458, F, F, H, 2-Th,
CH.sub.3), (M-4459, F, F, H, 3-Th, H), (M-4460, F, F, H, 3-Th, Cl),
(M-4461, F, F, H, 3-Th, F), (M-4462, F, F, H, 3-Th, CF.sub.3),
(M-4463, F, F, H, 3-Th, Br), (M-4464, F, F, H, 3-Th, CH.sub.3),
(M-4465, F, F, H, pyrrazol-2-yl, H), (M-4466, F, F, H,
pyrrazol-2-yl, Cl), (M-4467, F, F, H, pyrrazol-2-yl, F), (M-4468,
F, F, H, pyrrazol-2-yl, CF.sub.3), (M-4469, F, F, H, pyrrazol-2-yl,
Br), (M-4470, F, F, H, pyrrazol-2-yl, CH.sub.3), (M-4471, F, F, H,
pyrrazol-3-yl, H), (M-4472, F, F, H, pyrrazol-3-yl, Cl), (M-4473,
F, F, H, pyrrazol-3-yl, F), (M-4474, F, F, H, pyrrazol-3-yl,
CF.sub.3), (M-4475, F, F, H, pyrrazol-3-yl, Br), (M-4476, F, F, H,
pyrrazol-3-yl, CH.sub.3), (M-4477, F, F, H, pyrimidin-2-yl, H),
(M-4478, F, F, H, pyrimidin-2-yl, Cl), (M-4479, F, F, H,
pyrimidin-2-yl, F), (M-4480, F, F, H, pyrimidin-2-yl, CF.sub.3),
(M-4481, F, F, H, pyrimidin-2-yl, Br), (M-4482, F, F, H,
pyrimidin-2-yl, CH.sub.3), (M-4483, F, F, H, pyrimidin-4-yl, H),
(M-4484, F, F, H, pyrimidin-4-yl, Cl), (M-4485, F, F, H,
pyrimidin-4-yl, F), (M-4486, F, F, H, pyrimidin-4-yl, CF.sub.3),
(M-4487, F, F, H, pyrimidin-4-yl, Br), (M-4488, F, F, H,
pyrimidin-4-yl, CH.sub.3), (M-4489, F, F, H, pyrimidin-5-yl, H),
(M-4490, F, F, H, pyrimidin-5-yl, Cl), (M-4491, F, F, H,
pyrimidin-5-yl, F), (M-4492, F, F, H, pyrimidin-5-yl, CF.sub.3),
(M-4493, F, F, H, pyrimidin-5-yl, Br), (M-4494, F, F, H,
pyrimidin-5-yl, CH.sub.3), (M-4495, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2H), (M-4496, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2Cl), (M-4497, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-4498, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-4499, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2Br), (M-4500, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-4501, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-4502, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-4503, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4504, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4505, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-4506, F, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4507, F, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-4508, F, F,
H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-4509, F,
F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4510,
F, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-4511, F, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2, CH.sub.2,
Br), (M-4512, F, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4513,
F, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-4514, F, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-4515, F, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4516,
F, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-4517, F, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-4518, F, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-4519, F, F, H, MeOCH.sub.2, H), (M-4520, F, F, H, MeOCH.sub.2,
Cl), (M-4521, F, F, H, MeOCH.sub.2, F), (M-4522, F, F, H,
MeOCH.sub.2, CF.sub.3), (M-4523, F, F, H, MeOCH.sub.2, Br),
(M-4524, F, F, H, MeOCH.sub.2, CH.sub.3), (M-4525, F, F, H,
EtOCH.sub.2, H), (M-4526, F, F, H, EtOCH.sub.2, Cl), (M-4527, F, F,
H, EtOCH.sub.2, F), (M-4528, F, F, H, EtOCH.sub.2, CF.sub.3),
(M-4529, F, F, H, EtOCH.sub.2, Br), (M-4530, F, F, H, EtOCH.sub.2,
CH.sub.3), (M-4531, F, F, H, EtOCH.sub.2CH.sub.2, H), (M-4532, F,
F, H, EtOCH.sub.2CH.sub.2, Cl), (M-4533, F, F, H,
EtOCH.sub.2CH.sub.2, F), (M-4534, F, F, H, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-4535, F, F, H, EtOCH.sub.2CH.sub.2, Br), (M-4536, F,
F, H, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-4537, F, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-4538, F, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-4539, F, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-4540, F, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-4541, F, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-4542, F, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-4543, F, F, H,
MeOCH
.sub.2CH.sub.2, H), (M-4544, F, F, H, MeOCH.sub.2CH.sub.2, Cl),
(M-4545, F, F, H, MeOCH.sub.2CH.sub.2, F), (M-4546, F, F, H,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-4547, F, F, H,
MeOCH.sub.2CH.sub.2, Br), (M-4548, F, F, H, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-4549, F, F, H, HOCH.sub.2, H), (M-4550, F, F, H,
HOCH.sub.2, Cl), (M-4551, F, F, H, HOCH.sub.2, F), (M-4552, F, F,
H, HOCH.sub.2, CF.sub.3), (M-4553, F, F, H, HOCH.sub.2, Br),
(M-4554, F, F, H, HOCH.sub.2, CH.sub.3), (M-4555, F, F, H,
HOCH.sub.2CH.sub.2, H), (M-4556, F, F, H, HOCH.sub.2CH.sub.2, Cl),
(M-4557, F, F, H, HOCH.sub.2CH.sub.2, F), (M-4558, F, F, H,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-4559, F, F, H,
HOCH.sub.2CH.sub.2, Br), (M-4560, F, F, H, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-4561, F, F, H, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-4562, F, F, H, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-4563, F, F,
H, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-4564, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4565, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-4566, F, F, Pt,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4567, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-4568, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-4569, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4570, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4571, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-4572, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4573, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-4574, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-4575, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4576, F, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4577, F,
F, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-4578, F, F,
H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4579,
F, F, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-4580, F, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-4581, F, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-4582, F, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-4583, F, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-4584, F, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-4585, F, F, H,
(Me).sub.2N, H), (M-4586, F, F, H, (Me).sub.2N, Cl), (M-4587, F, F,
H, (Me).sub.2N, F), (M-4588, F, F, H, (Me).sub.2N, CF.sub.3),
(M-4589, F, F, H, (Me).sub.2N, Br), (M-4590, F, F, H, (Me).sub.2N,
CH.sub.3), (M-4591, F, F, H, piperidin-4-yl-methyl, H), (M-4592, F,
F, H, piperidin-4-yl-methyl, Cl), (M-4593, F, F, H,
piperidin-4-yl-methyl, F), (M-4594, F, F, H, piperidin-4-yl-methyl,
CF.sub.3), (M-4595, F, F, B, piperidin-4-yl-methyl, Br), (M-4596,
F, F, H, piperidin-4-yl-methyl, CH.sub.3), (M-4597, F, F, H,
cyclohexylmethyl, H), (M-4598, F, F, H, cyclohexylmethyl, Cl),
(M-4599, F, F, H, cyclohexylmethyl, F), (M-4600, F, F, H,
cyclohexylmethyl, CF.sub.3), (M-4601, F, F, H, cyclohexylmethyl,
Br), (M-4602, F, F, H, cyclohexylmethyl, CH.sub.3), (M-4603, F, F,
F, H, H), (M-4604, F, F, F, H, Cl), (M-4605, F, F, F, H, F),
(M-4606, F, F, F, H, CF.sub.3), (M-4607, F, F, F, H, Br), (M-4608,
F, F, F, H, CH.sub.3), (M-4609, F, F, F, F, H), (M-4610, F, F, F,
F, Cl), (M-4611, F, F, F, F, F), (M-4612, F, F, F, F, CF.sub.3),
(M-4613, F, F, F, F, Br), (M-4614, F, F, F, F, CH.sub.3), (M-4615,
F, F, F, Cl, H), (M-4616, F, F, F, Cl, Cl), (M-4617, F, F, F, Cl,
F), (M-4618, F, F, F, Cl, CF.sub.3), (M-4619, F, F, F, Cl, Br),
(M-4620, F, F, F, Cl, CH.sub.3), (M-4621, F, F, F, CH.sub.3, H),
(M-4622, F, F, F, CH.sub.3, Cl), (M-4623, F, F, F, CH.sub.3, F),
(M-4624, F, F, F, CH.sub.3, CF.sub.3), (M-4625, F, F, F, CH.sub.3,
Br), (M-4626, F, F, F, CH.sub.3, CH.sub.3), (M-4627, F, F, F, Et,
H), (M-4628, F, F, F, Et, Cl), (M-4629, F, F, F, Et, F), (M-4630,
F, F, F, Et, CF.sub.3), (M-4631, F, F, F, Et, Br), (M-4632, F, F,
F, Et, CH.sub.3), (M-4633, F, F, F, n-Pr, H), (M-4634, F, F, F,
n-Pr, Cl), (M-4635, F, F, F, n-Pr, F), (M-4636, F, F, F, n-Pr,
CF.sub.3), (M-4637, F, F, F, n-Pr, Br), (M-4638, F, F, F, n-Pr,
CH.sub.3), (M-4639, F, F, F, c-Pr, H), (M-4640, F, F, F, c-Pr, Cl),
(M-4641, F, F, F, c-Pr, F), (M-4642, F, F, F, c-Pr, CF.sub.3),
(M-4643, F, F, F, c-Pr, Br), (M-4644, F, F, F, c-Pr, CH.sub.3),
(M-4645, F, F, F, i-Pr, H), (M-4646, F, F, F, i-Pr, Cl), (M-4647,
F, F, F, i-Pr, F), (M-4648, F, F, F, i-Pr, CF.sub.3), (M-4649, F,
F, F, i-Pr, Br), (M-4650, F, F, F, i-Pr, CH.sub.3), (M-4651, F, F,
F, n-Bu, H), (M-4652, F, F, F, n-Bu, Cl), (M-4653, F, F, F, n-Bu,
F), (M-4654, F, F, F, n-Bu, CF.sub.3), (M-4655, F, F, F, n-Bu, Br),
(M-4656, F, F, F, n-Bu, CH.sub.3), (M-4657, F, F, F, i-Bu, H),
(M-4658, F, F, F, i-Bu, Cl), (M-4659, F, F, F, i-Bu, F), (M-4660,
F, F, F, i-Bu, CF.sub.3), (M-4661, F, F, F, i-Bu, Br), (M-4662, F,
F, F, i-Bu, CH.sub.3), (M-4663, F, F, F, sec-Bu, H), (M-4664, F, F,
F, sec-Bu, Cl), (M-4665, F, F, F, sec-Bu, F), (M-4666, F, F, F,
sec-Bu, CF.sub.3), (M-4667, F, F, F, sec-Bu, Br), (M-4668, F, F, F,
sec-Bu, CH.sub.3), (M-4669, F, F, F, n-Pen, H), (M-4670, F, F, F,
n-Pen, Cl), (M-4671, F, F, F, n-Pen, F), (M-4672, F, F, F, n-Pen,
CF.sub.3), (M-4673, F, F, F, n-Pen, Br), (M-4674, F, F, F, n-Pen,
CH.sub.3), (M-4675, F, F, F, c-Pen, H), (M-4676, F, F, F, c-Pen,
Cl), (M-4677, F, F, F, c-Pen, F), (M-4678, F, F, F, c-Pen,
CF.sub.3), (M-4679, F, F, F, c-Pen, Br), (M-4680, F, F, F, c-Pen,
CH.sub.3), (M-4681, F, F, F, n-Hex, H), (M-4682, F, F, F, n-Hex,
Cl), (M-4683, F, F, F, n-Hex, F), (M-4684, F, F, F, n-Hex,
CF.sub.3), (M-4685, F, F, F, n-Hex, Br), (M-4686, F, F, F, n-Hex,
CH.sub.3), (M-4687, F, F, F, c-Hex, H), (M-4688, F, F, F, c-Hex,
Cl), (M-4689, F, F, F, c-Hex, F), (M-4690, F, F, F, c-Hex,
CF.sub.3), (M-4691, F, F, F, c-Hex, Br), (M-4692, F, F, F, c-Hex,
CH.sub.3), (M-4693, F, F, F, OH, H), (M-4694, F, F, F, OH, Cl),
(M-4695, F, F, F, OH, F), (M-4696, F, F, F, OH, CF.sub.3), (M-4697,
F, F, F, OH, Br), (M-4698, F, F, F, OH, CH.sub.3), (M-4699, F, F,
F, EtO, H), (M-4700, F, F, F, EtO, Cl), (M-4701, F, F, F, EtO, F),
(M-4702, F, F, F, EtO, CF.sub.3), (M-4703, F, F, F, EtO, Br),
(M-4704, F, F, F, EtO, CH.sub.3), (M-4705, F, F, F, n-PrO, H),
(M-4706, F, F, F, n-PrO, Cl), (M-4707, F, F, F, n-PrO, F), (M-4708,
F, F, F, n-PrO, CF.sub.3), (M-4709, F, F, F, n-PrO, Br), (M-4710,
F, F, F, n-PrO, CH.sub.3), (M-4711, F, F, F, PhO, H), (M-4712, F,
F, F, PhO, Cl), (M-4713, F, F, F, PhO, F), (M-4714, F, F, F, PhO,
CF.sub.3), (M-4715, F, F, F, PhO, Br), (M-4716, F, F, F, PhO,
CH.sub.3), (M-4717, F, F, F, BnO, H), (M-4718, F, F, F, BnO, Cl),
(M-4719, F, F, F, BnO, F), (M-4720, F, F, F, BnO, CF.sub.3),
(M-4721, F, F, F, BnO, Br), (M-4722, F, F, F, BnO, CH.sub.3),
(M-4723, F, F, F, PhCH.sub.2CH.sub.2O, H), (M-4724, F, F, F,
PhCH.sub.2CH.sub.2O, Cl), (M-4725, F, F, F, PhCH.sub.2CH.sub.2O,
F), (M-4726, F, F, F, PhCH.sub.2CH.sub.2O, CF.sub.3), (M-4727, F,
F, F, PhCH.sub.2CH.sub.2O, Br), (M-4728, F, F, F,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-4729, F, F, F, CF.sub.3O, H),
(M-4730, F, F, F, CF.sub.3O, Cl), (M-4731, F, F, F, CF.sub.3O, F),
(M-4732, F, F, F, CF.sub.3O, CF.sub.3), (M-4733, F, F, F,
CF.sub.3O, Br), (M-4734, F, F, F, CF.sub.3O, CH.sub.3), (M-4735, F,
F, F, Ph, H), (M-4736, F, F, F, Ph, Cl), (M-4737, F, F, F, Ph, F),
(M-4738, F, F, F, Ph, CF.sub.3), (M-4739, F, F, F, Ph, Br),
(M-4740, F, F, F, Ph, CH.sub.3), (M-4741, F, F, F, 4-F-Ph, H),
(M-4742, F, F, F, 4-F-Ph, Cl), (M-4743, F, F, F, 4-F-Ph, F),
(M-4744, F, F, F, 4-F-Ph, CF.sub.3), (M-4745, F, F, F, 4-F-Ph, Br),
(M-4746, F, F, F, 4-F-Ph, CH.sub.3), (M-4747, F, F, F,
4-CF.sub.3-Ph, H), (M-4748, F, F, F, 4-CF.sub.3-Ph, Cl), (M-4749,
F, F, F, 4-CF.sub.3-Ph, F), (M-4750, F, F, F, 4-CF.sub.3-Ph,
CF.sub.3), (M-4751, F, F, F, 4-CF.sub.3-Ph, Br), (M-4752, F, F, F,
4-CF.sub.3-Ph, CH.sub.3), (M-4753, F, F, F, 4-(Me).sub.2N-Ph, H),
(M-4754, F, F, F, 4-(Me).sub.2N-Ph, Cl), (M-4755, F, F, F,
4-(Me).sub.2N-Ph, F), (M-4756, F, F, F, 4-(Me).sub.2N-Ph,
CF.sub.3), (M-4757, F, F, F, 4-(Me).sub.2N-Ph, Br), (M-4758, F, F,
F, 4-(Me).sub.2N-Ph, CH.sub.3), (M-4759, F, F, F, 4-OH-Ph, H),
(M-4760, F, F, F, 4-OH-Ph, Cl), (M-4761, F, F, F, 4-OH-Ph, F),
(M-4762, F, F, F, 4-OH-Ph, CF.sub.3), (M-4763, F, F, F, 4-OH-Ph,
Br), (M-4764, F, F, F, 4-OH-Ph, CH.sub.3), (M-4765, F, F, F,
3,4-di-F-Ph, H), (M-4766, F, F, F, 3,4-di-F-Ph, Cl), (M-4767, F, F,
F, 3,4-di-F-Ph, F), (M-4768, F, F, F, 3,4-di-F-Ph, CF.sub.3),
(M-4769, F, F, F, 3,4-di-F-Ph, Br), (M-4770, F, F, F, 3,4-di-F-Ph,
CH.sub.3), (M-4771, F, F, F, 4-COOH-Ph, H), (M-4772, F, F, F,
4-COOH-Ph, Cl), (M-4773, F, F, F, 4-COOH-Ph, F), (M-4774, F, F, F,
4-COOH-Ph, CF.sub.3), (M-4775, F, F, F, 4-COOH-Ph, Br), (M-4776, F,
F, F, 4-COOH-Ph, CH.sub.3), (M-4777, F, F, F, Bn, H), (M-4778, F,
F, F, Bn, Cl), (M-4779, F, F, F, Bn, F), (M-4780, F, F, F, Bn,
CF.sub.3), (M-4781, F, F, F, Bn, Br), (M-4782, F, F, F, Bn,
CH.sub.3), (M-4783, F, F, F, 4-F-Bn, H), (M-4784, F, F, F, 4-F-Bn,
Cl), (M-4785, F, F, F, 4-F-Bn, F), (M-4786, F, F, F, 4-F-Bn,
CF.sub.3), (M-4787, F, F, F, 4-F-Bn, Br), (M-4788, F, F, F, 4-F-Bn,
CH.sub.3), (M-4789, F, F, F, 2-Py, H), (M-4790, F, F, F, 2-Py, Cl),
(M-4791, F, F, F, 2-Py, F), (M-4792, F, F, F, 2-Py, CF.sub.3),
(M-4793, F, F, F, 2-Py, Br), (M-4794, F, F, F, 2-Py, CH.sub.3),
(M-4795, F, F, F, 3-Py, H), (M-4796, F, F, F, 3-Py, Cl), (M-4797,
F, F, F, 3-Py, F), (M-4798, F, F, F, 3-Py, CF.sub.3), (M-4799, F,
F, F, 3-Py, Br), (M-4800, F, F, F, 3-Py, CH.sub.3), (M-4801, F, F,
F, 4-Py, H), (M-4802, F, F, F, 4-Py, Cl), (M-4803, F, F, F, 4-Py,
F), (M-4804, F, F, F, 4-Py, CF.sub.3), (M-4805, F, F, F, 4-Py, Br),
(M-4806, F, F, F, 4-Py, CH.sub.3), (M-4807, F, F, F, 2-Th, H),
(M-4808, F, F, F, 2-Th, Cl), (M-4809, F, F, F, 2-Th, F), (M-4810,
F, F, F, 2-Th, CF.sub.3), (M-4811, F, F, F, 2-Th, Br), (M-4812, F,
F, F, 2-Th, CH.sub.3), (M-4813, F, F, F, 3-Th, H), (M-4814, F, F,
F, 3-Th, Cl), (M-4815, F, F, F, 3-Th, F), (M-4816, F, F, F, 3-Th,
CF.sub.3), (M-4817, F, F, F, 3-Th, Br), (M-4818, F, F, F, 3-Th,
CH.sub.3), (M-4819, F, F, F, pyrrazol-2-yl, H), (M-4820, F, F, F,
pyrrazol-2-yl, Cl), (M-4821, F, F, F, pyrrazol-2-yl, F), (M-4822,
F, F, F, pyrrazol-2-yl, CF.sub.3), (M-4823, F, F, F, pyrrazol-2-yl,
Br), (M-4824, F, F, F, pyrrazol-2-yl, CH.sub.3), (M-4825, F, F, F,
pyrrazol-3-yl, H), (M-4826, F, F, F, pyrrazol-3-yl, Cl), (M-4827,
F, F, F, pyrrazol-3-yl, F), (M-4828, F, F, F, pyrrazol-3-yl,
CF.sub.3), (M-4829, F, F, F, pyrrazol-3-yl, Br), (M-4830, F, F, F,
pyrrazol-3-yl, CH.sub.3), (M-4831, F, F, F, pyrimidin-2-yl, H),
(M-4832, F, F, F, pyrimidin-2-yl, Cl), (M-4833, F, F, F,
pyrimidin-2-yl, F), (M-4834, F, F, F, pyrimidin-2-yl, CF.sub.3),
(M-4835, F, F, F, pyrimidin-2-yl, Br), (M-4836, F, F, F,
pyrimidin-2-yl, CH.sub.3), (M-4837, F, F, F, pyrimidin-4-yl, H),
(M-4838, F, F, F, pyrimidin-4-yl, Cl), (M-4839, F, F, F,
pyrimidin-4-yl, F), (M-4840, F, F, F, pyrimidin-4-yl, CF.sub.3),
(M-4841, F, F, F, pyrimidin-4-yl, Br), (M-4842, F, F, F,
pyrimidin-4-yl, CH.sub.3), (M-4843, F, F, F, pyrimidin-5-yl, H),
(M-4844, F, F, F, pyrimidin-5-yl, Cl), (M-4845, F, F, F,
pyrimidin-5-yl, F), (M-4846, F, F, F, pyrimidin-5-yl, CF.sub.3),
(M-4847, F, F, F, pyrimidin-5-yl, Br), (M-4848, F, F, F,
pyrimidin-5-yl, CH.sub.3), (M-4849, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-4850, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-4851, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-4852, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4853, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-4854, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4855, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-4856, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-4857, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4858, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4859, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-4860, F, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4861, F, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-4862, F, F,
F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-4863, F,
F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4864,
F, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-4865, F, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-4866, F, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4867,
F, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-4868, F, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-4869, F, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4870,
F, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-4871, F, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-4872, F, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-4873, F, F, F, MeOCH.sub.2, H), (M-4874, F, F, F, MeOCH.sub.2,
Cl), (M-4875, F, F, F, MeOCH.sub.2, F), (M-4876, F, F, F,
MeOCH.sub.2, CF.sub.3), (M-4877, F, F, F, MeOCH.sub.2, Br),
(M-4878, F, F, F, MeOCH.sub.2, CH.sub.3), (M-4879, F, F, F,
EtOCH.sub.2, H), (M-4880, F, F, F, EtOCH.sub.2, Cl), (M-4881, F, F,
F, EtOCH.sub.2, F), (M-4882, F, F, F, EtOCH.sub.2, CF.sub.3),
(M-4883, F, F, F, EtOCH.sub.2, Br), (M-4884, F, F, F, EtOCH.sub.2,
CH.sub.3), (M-4885, F, F, F, EtOCH.sub.2CH.sub.2, H), (M-4886, F,
F, F, EtOCH.sub.2CH.sub.2, Cl), (M-4887, F, F, F,
EtOCH.sub.2CH.sub.2, F), (M-4888, F, F, F, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-4889, F, F, F, EtOCH.sub.2CH.sub.2, Br), (M-4890, F,
F, F, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-4891, F, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-4892, F, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-4893, F, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-4894, F, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-4895, F, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-4896, F, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-4897, F, F, F,
MeOCH.sub.2CH.sub.2, H), (M-4898, F, F, F, MeOCH.sub.2CH.sub.2,
Cl), (M-4899, F, F, F, MeOCH.sub.2CH.sub.2, F), (M-4900, F, F, F,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-4901, F, F, F,
MeOCH.sub.2CH.sub.2, Br), (M-4902, F, F, F, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-4903, F, F, F, HOCH.sub.2, H), (M-4904, F, F, F,
HOCH.sub.2, Cl), (M-4905, F, F, F, HOCH.sub.2, F), (M-4906, F, F,
F, HOCH.sub.2, CF.sub.3), (M-4907, F, F, F, HOCH.sub.2, Br),
(M-4908, F, F, F, HOCH.sub.2, CH.sub.3), (M-4909, F, F, F,
HOCH.sub.2CH.sub.2, H), (M-4910, F, F, F, HOCH.sub.2CH.sub.2, Cl),
(M-4911, F, F, F, HOCH.sub.2CH.sub.2, F), (M-4912, F, F, F,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-4913, F, F, F,
HOCH.sub.2CH.sub.2, Br), (M-4914, F, F, F, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-4915, F, F, F, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-4916, F, F, F, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-4917, F, F,
F, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-4918, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4919, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-4920, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4921, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-4922, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2
CH.sub.2, Cl), (M-4923, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4924, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-4925, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-4926, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-4927, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-4928, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-4929, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-4930, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-4931, F, F,
F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-4932, F, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-4933, F, F,
F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-4934, F, F, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-4935, F, F, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-4936, F, F, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-4937, F, F, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-4938, F, F, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-4939, F, F, F,
(Me).sub.2N, H), (M-4940, F, F, F, (Me).sub.2N, Cl), (M-4941, F, F,
F, (Me).sub.2N, F), (M-4942, F, F, F, (Me).sub.2N, CF.sub.3),
(M-4943, F, F, F, (Me).sub.2N, Br), (M-4944, F, F, F, (Me).sub.2N,
CH.sub.3), (M-4945, F, F, F, piperidin-4-yl-methyl, H), (M-4946, F,
F, F, piperidin-4-yl-methyl, Cl), (M-4947, F, F, F,
piperidin-4-yl-methyl, F), (M-4948, F, F, F, piperidin-4-yl-methyl,
CF.sub.3), (M-4949, F, F, F, piperidin-4-yl-methyl, Br), (M-4950,
F, F, F, piperidin-4-yl-methyl, CH.sub.3), (M-4951, F, F, F,
cyclohexylmethyl, H), (M-4952, F, F, F, cyclohexylmethyl, Cl),
(M-4953, F, F, F, cyclohexylmethyl, F), (M-4954, F, F, F,
cyclohexylmethyl, CF.sub.3), (M-4955, F, F, F, cyclohexylmethyl,
Br), (M-4956, F, F, F, cyclohexylmethyl, CH.sub.3), (M-4957, F, F,
Cl, H, H), (M-4958, F, F, Cl, H, Cl), (M-4959, F, F, Cl, H, F),
(M-4960, F, F, Cl, H, CF.sub.3), (M-4961, F, F, Cl, H, Br),
(M-4962, F, F, Cl, H, CH.sub.3), (M-4963, F, F, Cl, F, H), (M-4964,
F, F, Cl, F, Cl), (M-4965, F, F, Cl, F, F), (M-4966, F, F, Cl, F,
CF.sub.3), (M-4967, F, F, Cl, F, Br), (M-4968, F, F, Cl, F,
CH.sub.3), (M-4969, F, F, Cl, Cl, H), (M-4970, F, F, Cl, Cl, Cl),
(M-4971, F, F, Cl, Cl, F), (M-4972, F, F, Cl, Cl, CF.sub.3),
(M-4973, F, F, Cl, Cl, Br), (M-4974, F, F, Cl, Cl, CH.sub.3),
(M-4975, F, F, Cl, CH.sub.3, H), (M-4976, F, F, Cl, CH.sub.3, Cl),
(M-4977, F, F, Cl, CH.sub.3, F), (M-4978, F, F, Cl, CH.sub.3,
CF.sub.3), (M-4979, F, F, Cl, CH.sub.3, Br), (M-4980, F, F, Cl,
CH.sub.3, CH.sub.3), (M-4981, F, F, Cl, Et, H), (M-4982, F, F, Cl,
Et, Cl), (M-4983, F, F, Cl, Et, F), (M-4984, F, F, Cl, Et,
CF.sub.3), (M-4985, F, F, Cl, Et, Br), (M-4986, F, F, Cl, Et,
CH.sub.3), (M-4987, F, F, Cl, Q-Pr, H), (M-4988, F, F, Cl, n-Pr,
Cl), (M-4989, F, F, Cl, n-Pr, F), (M-4990, F, F, Cl, n-Pr,
CF.sub.3), (M-4991, F, F, Cl, n-Pr, Br), (M-4992, F, F, Cl, n-Pr,
CH.sub.3), (M-4993, F, F, Cl, c-Pr, H), (M-4994, F, F, Cl, c-Pr,
Cl), (M-4995, F, F, Cl, c-Pr, F), (M-4996, F, F, Cl, c-Pr,
CF.sub.3), (M-4997, F, F, Cl, c-Pr, Br), (M-4998, F, F, Cl, c-Pr,
CH.sub.3), (M-4999, F, F, Cl, i-Pr, H), (M-5000, F, F, Cl, i-Pr,
Cl), (M-5001, F, F, Cl, i-Pr, F), (M-5002, F, F, Cl, i-Pr,
CF.sub.3), (M-5003, F, F, Cl, i-Pr, Br), (M-5004, F, F, Cl, i-Pr,
CH.sub.3), (M-5005, F, F, Cl, n-Bu, H), (M-5006, F, F, Cl, n-Bu,
Cl), (M-5007, F, F, Cl, n-Bu, F), (M-5008, F, F, Cl, n-Bu,
CF.sub.3), (M-5009, F, F, Cl, n-Bu, Br), (M-5010, F, F, Cl, n-Bu,
CH.sub.3), (M-5011, F, F, Cl, i-Bu, H), (M-5012, F, F, Cl, i-Bu,
Cl), (M-5013, F, F, Cl, i-Bu, F), (M-5014, F, F, Cl, i-Bu,
CF.sub.3), (M-5015, F, F, Cl, i-Bu, Br), (M-5016, F, F, Cl, i-Bu,
CH.sub.3), (M-5017, F, F, Cl, sec-Bu, H), (M-5018, F, F, Cl,
sec-Bu, Cl), (M-5019, F, F, Cl, sec-Bu, F), (M-5020, F, F, Cl,
sec-Bu, CF.sub.3), (M-5021, F, F, Cl, sec-Bu, Br), (M-5022, F, F,
Cl, sec-Bu, CH.sub.3), (M-5023, F, F, Cl, n-Pen, H), (M-5024, F, F,
Cl, n-Pen, Cl), (M-5025, F, F, Cl, n-Pen, F), (M-5026, F, F, Cl,
n-Pen, CF.sub.3), (M-5027, F, F, Cl, n-Pen, Br), (M-5028, F, F, Cl,
n-Pen, CH.sub.3), (M-5029, F, F, Cl, c-Pen, H), (M-5030, F, F, Cl,
c-Pen, Cl), (M-5031, F, F, Cl, c-Pen, F), (M-5032, F, F, Cl, c-Pen,
CF.sub.3), (M-5033, F, F, Cl, c-Pen, Br), (M-5034, F, F, Cl, c-Pen,
CH.sub.3), (M-5035, F, F, Cl, n-Hex, H), (M-5036, F, F, Cl, n-Hex,
Cl), (M-5037, F, F, Cl, n-Hex, F), (M-5038, F, F, Cl, n-Hex,
CF.sub.3), (M-5039, F, F, Cl, n-Hex, Br), (M-5040, F, F, Cl, n-Hex,
CH.sub.3), (M-5041, F, F, Cl, c-Hex, H), (M-5042, F, F, Cl, c-Hex,
Cl), (M-5043, F, F, Cl, c-Hex, F), (M-5044, F, F, Cl, c-Hex,
CF.sub.3), (M-5045, F, F, Cl, c-Hex, Br), (M-5046, F, F, Cl, c-Hex,
CH.sub.3), (M-5047, F, F, Cl, OH, H), (M-5048, F, F, Cl, OH, Cl),
(M-5049, F, F, Cl, OH, F), (M-5050, F, F, Cl, OH, CF.sub.3),
(M-5051, F, F, Cl, OH, Br), (M-5052, F, F, Cl, OH, CH.sub.3),
(M-5053, F, F, Cl, EtO, H), (M-5054, F, F, Cl, EtO, Cl), (M-5055,
F, F, Cl, EtO, F), (M-5056, F, F, Cl, EtO, CF.sub.3), (M-5057, F,
F, Cl, EtO, Br), (M-5058, F, F, Cl, EtO, CH.sub.3), (M-5059, F, F,
Cl, n-PrO, H), (M-5060, F, F, Cl, n-PrO, Cl), (M-5061, F, F, Cl,
n-PrO, F), (M-5062, F, F, Cl, n-PrO, CF.sub.3), (M-5063, F, F, Cl,
n-PrO, Br), (M-5064, F, F, Cl, n-PrO, CH.sub.3), (M-5065, F, F, Cl,
PhO, H), (M-5066, F, F, Cl, PhO, Cl), (M-5067, F, F, Cl, PhO, F),
(M-5068, F, F, Cl, PhO, CF.sub.3), (M-5069, F, F, Cl, PhO, Br),
(M-5070, F, F, Cl, PhO, CH.sub.3), (M-5071, F, F, Cl, BnO, H),
(M-5072, F, F, Cl, BnO, Cl), (M-5073, F, F, Cl, BnO, F), (M-5074,
F, F, Cl, BnO, CF.sub.3), (M-5075, F, F, Cl, BnO, Br), (M-5076, F,
F, Cl, BnO, CH.sub.3), (M-5077, F, F, Cl, PhCH.sub.2CH.sub.2O, H),
(M-5078, F, F, Cl, PhCH.sub.2CH.sub.2O, Cl), (M-5079, F, F, Cl,
PhCH.sub.2CH.sub.2O, F), (M-5080, F, F, Cl, PhCH.sub.2CH.sub.2O,
CF.sub.3), (M-5081, F, F, Cl, PhCH.sub.2CH.sub.2O, Br), (M-5082, F,
F, Cl, PhCH.sub.2CH.sub.2O, CH.sub.3), (M-5083, F, F, Cl,
CF.sub.3O, H), (M-5084, F, F, Cl, CF.sub.3O, Cl), (M-5085, F, F,
Cl, CF.sub.3O, F), (M-5086, F, F, Cl, CF.sub.3O, CF.sub.3),
(M-5087, F, F, Cl, CF.sub.3O, Br), (M-5088, F, F, Cl, CF.sub.3O,
CH.sub.3), (M-5089, F, F, Cl, Ph, H), (M-5090, F, F, Cl, Ph, Cl),
(M-5091, F, F, Cl, Ph, F), (M-5092, F, F, Cl, Ph, CF.sub.3),
(M-5093, F, F, Cl, Ph, Br), (M-5094, F, F, Cl, Ph, CH.sub.3),
(M-5095, F, F, Cl, 4-F-Ph, H), (M-5096, F, F, Cl, 4-F-Ph, Cl),
(M-5097, F, F, Cl, 4-F-Ph, F, (M-5098, F, F, Cl, 4-F-Ph, CF.sub.3),
(M-5099, F, F, Cl, 4-F-Ph, Br), (M-5100, F, F, Cl, 4-F-Ph,
CH.sub.3), (M-5101, F, F, Cl, 4-CF.sub.3-Ph, H), (M-5102, F, F, Cl,
4-CF.sub.3-Ph, Cl), (M-5103, F, F, Cl, 4-CF.sub.3-Ph, F), (M-5104,
F, F, Cl, 4-CF.sub.3-Ph, CF.sub.3), (M-5105, F, F, Cl,
4-CF.sub.3-Ph, Br), (M-5106, F, F, Cl, 4-CF.sub.3-Ph, CH.sub.3),
(M-5107, F, F, Cl, 4-(Me).sub.2N-Ph, H), (M-5108, F, F, Cl,
4-<Me).sub.2N-Ph, Cl), (M-5109, F, F, Cl, 4-(Me).sub.2N-Ph, F),
(M-5110, F, F, Cl, 4-(Me).sub.2N-Ph, CF.sub.3), (M-5111, F, F, Cl,
4-(Me).sub.2N-Ph, Br), (M-5112, F, F, Cl, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-5113, F, F, Cl, 4-OH-Ph, H), (M-5114, F, F, Cl,
4-OH-Ph, Cl), (M-5115, F, F, Cl, 4-OH-Ph, F), (M-5116, F, F, Cl,
4-OH-Ph, CF.sub.3), (M-5117, F, F, Cl, 4-OH-Ph, Br), (M-5118, F, F,
Cl, 4-OH-Ph, CH.sub.3), (M-5119, F, F, Cl, 3,4-di-F-Ph, H),
(M-5120, F, F, Cl, 3,4-di-F-Ph, Cl), (M-5121, F, F, Cl,
3,4-di-F-Ph, F), (M-5122, F, F, Cl, 3,4-di-F-Ph, CF.sub.3),
(M-5123, F, F, Cl, 3,4-di-F-Ph, Br), (M-5124, F, F, Cl,
3,4-di-F-Ph, CH.sub.3), (M-6125, F, F, Cl, 4-COOH-Ph, H), (M-5126,
F, F, Cl, 4-COOH-Ph, Cl), (M-5127, F, F, Cl, 4-COOH-Ph, F),
(M-5128, F, F, Cl, 4-COOH-Ph, CF.sub.3), (M-5129, F, F, Cl,
4-COOH-Ph, Br), (M-5130, F, F, Cl, 4-COOH-Ph, CH.sub.3), (M-5131,
F, F, Cl, Bn, H), (M-5132, F, F, Cl, Bn, Cl), (M-5133, F, F, Cl,
Bn, F), (M-5134, F, F, Cl, Bn, CF.sub.3), (M-5135, F, F, Cl, Bn,
Br), (M-5136, F, F, Cl, Bn, CH.sub.3), (M-5137, F, F, Cl, 4-F-Bn,
H), (M-5138, F, F, Cl, 4-F-Bn, Cl), (M-5139, F, F, Cl, 4-F-Bn, F),
(M-5140, F, F, Cl, 4-F-Bn, CF.sub.3), (M-5141, F, F, Cl, 4-F-Bn,
Br), (M-5142, F, F, Cl, 4-F-Bn, CH.sub.3), (M-5143, F, F, Cl, 2-Py,
H), (M-5144, F, F, Cl, 2-Py, Cl), (M-5145, F, F, Cl, 2-Py, F),
(M-5146, F, F, Cl, 2-Py, CF.sub.3), (M-5147, F, F, Cl, 2-Py, Br),
(M-5148, F, F, Cl, 2-Py, CH.sub.3), (M-5149, F, F, Cl, 3-Py, H),
(M-5150, F, F, Cl, 3-Py, Cl), (M-5151, F, F, Cl, 3-Py, F), (M-5152,
F, F, Cl, 3-Py, CF.sub.3), (M-5153, F, F, Cl, 3-Py, Br), (M-5154,
F, F, Cl, 3-Py, CH.sub.3), (M-5155, F, F, Cl, 4-Py, H), (M-5156, F,
F, Cl, 4-Py, Cl), (M-5157, F, F, Cl, 4-Py, F), (M-5158, F, F, Cl,
4-Py, CF.sub.3), (M-5159, F, F, Cl, 4-Py, Br), (M-5160, F, F, Cl,
4-Py, CH.sub.3), (M-5161, F, F, Cl, 2-Th, H), (M-5162, F, F, Cl,
2-Th, Cl), (M-5163, F, F, Cl, 2-Th, F), (M-5164, F, F, Cl, 2-Th,
CF.sub.3), (M-5165, F, F, Cl, 2-Th, Br), (M-5166, F, F, Cl, 2-Th,
CH.sub.3), (M-5167, F, F, Cl, 3-Th, H), (M-5168, F, F, Cl, 3-Th,
Cl), (M-5169, F, F, Cl, 3-Th, F), (M-6170, F, F, Cl, 3-Th,
CF.sub.3), (M-5171, F, F, Cl, 3-Th, Br), (M-5172, F, F, Cl, 3-Th,
CH.sub.3), (M-5173, F, F, Cl, pyrrazol-2-yl, H), (M-5174, F, F, Cl,
pyrrazol-2-yl, Cl), (M-5175, F, F, Cl, pyrrazol-2-yl, F), (M-5176,
F, F, Cl, pyrrazol-2-yl, CF.sub.3), (M-5177, F, F, Cl,
pyrrazol-2-yl, Br), (M-5178, F, F, Cl, pyrrazol-2-yl, CH.sub.3),
(M-5179, F, F, Cl, pyrrazol-3-yl, H), (M-5180, F, F, Cl,
pyrrazol-3-yl, Cl), (M-5181, F, F, Cl, pyrrazol-3-yl, F), (M-5182,
F, F, Cl, pyrrazol-3-yl, CF.sub.3), (M-5183, F, F, Cl,
pyrrazol-3-yl, Br), (M-5184, F, F, Cl, pyrrazol-3-yl, CH.sub.3),
(M-5185, F, F, Cl, pyrimidin-2-yl, H), (M-5186, F, F, Cl,
pyrimidin-2-yl, Cl), (M-5187, F, F, Cl, pyrimidin-2-yl, F),
(M-5188, F, F, Cl, pyrimidin-2-yl, CF.sub.3), (M-5189, F, F, Cl,
pyrimidin-2-yl, Br), (M-5190, F, F, Cl, pyrimidin-2-yl, CH.sub.3),
(M-5191, F, F, Cl, pyrimidin-4-yl, H), (M-5192, F, F, Cl,
pyrimidin-4-yl, Cl), (M-5193, F, F, Cl, pyrimidin-4-yl, F),
(M-5194, F, F, Cl, pyrimidin-4-yl, CF.sub.3), (M-5195, F, F, Cl,
pyrimidin-4-yl, Br), (M-5196, F, F, Cl, pyrimidin-4-yl, CH.sub.3),
(M-5197, F, F, Cl, pyrimidin-5-yl, H), (M-5198, F, F, Cl,
pyrimidin-5-yl, Cl), (M-5199, F, F, Cl, pyrimidin-5-yl, F),
(M-5200, F, F, Cl, pyrimidin-5-yl, CF.sub.3), (M-5201, F, F, Cl,
pyrimidin-5-yl, Br), (M-5202, F, F, Cl, pyrimidin-5-yl, CH.sub.3),
(M-5203, F, F, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-5204, F, F,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-5205, F, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-5206, F, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-5207, F, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-5208, F, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-5209, F, F, Cl,
HOOCCH.sub.2CH.sub.26H.sub.2CH.sub.2, H), (M-5210, F, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-5211, F, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5212, F, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-5213, F, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-5214, F, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-5215, F, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5216, F, F,
Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-5217, F,
F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5218,
F, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-5219, F, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-5220, F, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-5221,
F, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
H), (M-5222, F, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-5223, F, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5224,
F, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-5225, F, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-5226, F, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-5227, F, F, Cl, MeOCH.sub.2, H), (M-5228, F, F, Cl, MeOCH.sub.2,
Cl), (M-5229, F, F, Cl, MeOCH.sub.2, F), (M-5230, F, F, Cl,
MeOCH.sub.2, CF.sub.3), (M-5231, F, F, Cl, MeOCH.sub.2, Br),
(M-5232, F, F, Cl, MeOCH.sub.2, CH.sub.3), (M-5233, F, F, Cl,
EtOCH.sub.2, H), (M-5234, F, F, Cl, EtOCH.sub.2, Cl), (M-5235, F,
F, Cl, EtOCH.sub.2, F), (M-5236, F, F, Cl, EtOCH.sub.2, CF.sub.3),
(M-5237, F, F, Cl, EtOCH.sub.2, Br), (M-5238, F, F, Cl,
EtOCH.sub.2, CH.sub.3), (M-5239, F, F, Cl, EtOCH.sub.2CH.sub.2, H),
(M-5240, F, F, Cl, EtOCH.sub.2CH.sub.2, Cl), (M-5241, F, F, Cl,
EtOCH.sub.2CH.sub.2, F), (M-5242, F, F, Cl, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-5243, F, F, Cl, EtOCH.sub.2CH.sub.2, Br), (M-5244, F,
F, Cl, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-5245, F, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-5246, F, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-5247, F, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-5248, F, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-5249, F, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-5250, F, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-5251, F, F, Cl,
MeOCH.sub.2CH.sub.2, H), (M-5252, F, F, Cl, MeOCH.sub.2CH.sub.2,
Cl), (M-5253, F, F, Cl, MeOCH.sub.2CH.sub.2, F), (M-5254, F, F, Cl,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-5255, F, F, Cl,
MeOCH.sub.2CH.sub.2, Br), (M-5256, F, F, Cl, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-5257, F, F, Cl, HOCH.sub.2, H), (M-5258, F, F, Cl,
HOCH.sub.2, Cl), (M-5259, F, F, Cl, HOCH.sub.2, F), (M-5260, F, F,
Cl, HOCH.sub.2, CF.sub.3), (M-5261, F, F, Cl, HOCH.sub.2, Br),
(M-5262, F, F, Cl, HOCH.sub.2, CH.sub.3), (M-5263, F, F, Cl,
HOCH.sub.2CH.sub.2, H), (M-5264, F, F, Cl, HOCH.sub.2CH.sub.2, Cl),
(M-5265, F, F, Cl, HOCH.sub.2CH.sub.2, F), (M-5266, F, F, Cl,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-5267, F, F, Cl,
HOCH.sub.2CH.sub.2, Br), (M-5268, F, F, Cl, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-5269, F, F, Cl, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-5270, F, F, Cl, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-5271, F, F,
Cl HOCH.sub.2CH.sub.2CH.sub.2, F), (M-5272, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-5273, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-5274, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-5275, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5276, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-5277, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5278, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-5279, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-5280, F, F, Cl,
HOCH.sub.2CH.sub.1CH.sub.2CH.sub.2, CH.sub.3), (M-5281, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5282, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-5283, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5284, F, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-5285, F, F,
Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-5286, F, F,
Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-5287,
F, F, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-5288, F, F,
Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-5289, F, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2
CH.sub.2, F), (M-5290, F, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-5291, F, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-5292, F, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-5293, F, F, Cl,
(Me).sub.2N, H), (M-5294, F, F, Cl, (Me).sub.2N, Cl), (M-5295, F,
F, Cl, (Me).sub.2N, F), (M-5296, F, F, Cl, (Me).sub.2N, CF.sub.3),
(M-5297, F, F, Cl, (Me).sub.3N, Br), (M-5298, F, F, Cl,
(Me).sub.2N, CH.sub.3), (M-5299, F, F, Cl, piperidin-4-yl-methyl,
H), (M-5300, F, F, Cl, piperidin-4-yl-methyl, Cl), (M-5301, F, F,
Cl, piperidin-4-yl-methyl, F), (M-5302, F, F, Cl,
piperidin-4-yl-methyl, CF.sub.3), (M-5303, F, F, Cl,
piperidin-4-yl-methyl, Br), (M-5304, F, F, Cl,
piperidin-4-yl-methyl, CH.sub.3), (M-5305, F, F, Cl,
cyclohexylmethyl, H), (M-5306, F, F, Cl, cyclohexylmethyl, Cl),
(M-5307, F, F, Cl, cyclohexylmethyl, F), (M-5308, F, F, Cl,
cyclohexylmethyl, CF.sub.3), (M-5309, F, F, Cl, cyclohexylmethyl,
Br), (M-5310, F, F, Cl, cyclohexylmethyl, CH.sub.3), (M-53H, F,
CH.sub.3, H, H, H), (M-5312, F, CH.sub.3, H, H, Cl), (M-5313, F,
CH.sub.3, H, H, F), (M-5314, F, CH.sub.3, H, H, CF.sub.3), (M-5315,
F, CH.sub.3, H, H, Br), (M-5316, F, CH.sub.3, H, H, CH.sub.3),
(M-5317, F, CH.sub.3, H, F, H), (M-5318, F, CH.sub.3, H, F, Cl),
(M-5319, F, CH.sub.3, H, F, F), (M-5320, F, CH.sub.3, H, F,
CF.sub.3), (M-5321, F, CH.sub.3, H, F, Br), (M-5322, F, CH.sub.3,
H, F, CH.sub.3), (M-5323, F, CH.sub.3, H, Cl, H), (M-5324, F,
CH.sub.3, H, Cl, Cl), (M-5325, F, CH.sub.3, H, Cl, F), (M-5326, F,
CH.sub.3, H, Cl, CF.sub.3), (M-5327, F, CH.sub.3, H, Cl, Br),
(M-5328, F, CH.sub.3, H, Cl, CH.sub.3), (M-5329, F, CH.sub.3, H,
CH.sub.3, H), (M-5330, F, CH.sub.3, H, CH.sub.3, Cl), (M-5331, F,
CH.sub.3, H, CH.sub.3, F), (M-5332, F, CH.sub.3, H, CH.sub.3,
CF.sub.3), (M-5333, F, CH.sub.3, H, CH.sub.3, Br), (M-5334, F,
CH.sub.3, H, CH.sub.3, CH.sub.3), (M-5335, F, CH.sub.3, H, Et, H),
(M-5336, F, CH.sub.3, H, Et, Cl), (M-5337, F, CH.sub.3, H, Et, F),
(M-5338, F, CH.sub.3, H, Et, CF.sub.3), (M-5339, F, CH.sub.3, H,
Et, Br), (M-5340, F, CH.sub.3, H, Et, CH.sub.3), (M-5341, F,
CH.sub.3, H, n-Pr, H), (M-5342, F, CH.sub.3, H, n-Pr, Cl), (M-5343,
F, CH.sub.3, H, n-Pr, F), (M-5344, P, CH.sub.3, H, n-Pr, CF.sub.3),
(M-5345, F, CH.sub.3, H, n-Pr, Br), (M-5346, F, CH.sub.3, H, n-Pr,
CH.sub.3), (M-5347, F, CH.sub.3, H, c-Pr, H), (M-5348, F, CH.sub.3,
H, c-Pr, Cl), (M-5349, F, CH.sub.3, H, c-Pr, F), (M-5350, F,
CH.sub.3, H, c-Pr, CF.sub.3), (M-5351, F, CH.sub.3, H, c-Pr, Br),
(M-5352, F, CH.sub.3, H, c-Pr, CH.sub.3), (M-5353, F, CH.sub.3, H,
i-Pr, H), (M-5354, F, CH.sub.3, H, i-Pr, Cl), (M-5355, F, CH.sub.3,
H, i-Pr, F), (M-5356, F, CH.sub.3, H, i-Pr, CF.sub.3), (M-5357, F,
CH.sub.3, H, i-Pr, Br), (M-5358, F, CH.sub.3, H, i-Pr, CH.sub.3),
(M-5359, F, CH.sub.3, H, n-Bu, H), (M-5360, F, CH.sub.3, H, n-Bu,
Cl), (M-5361, F, CH.sub.3, H, n-Bu, F), (M-5362, F, CH.sub.3, H,
n-Bu, CF.sub.3), (M-5363, F, CH.sub.3, H, n-Bu, Br), (M-5364, F,
CH.sub.3, H, n-Bu, CH.sub.3), (M-5365, F, CH.sub.3, H, i-Bu, H),
(M-5366, F, CH.sub.3, H, i-Bu, Cl), (M-5367, F, CH.sub.3, H, i-Bu,
F), (M-5368, F, CH.sub.3, H, i-Bu, CF.sub.3), (M-5369, F, CH.sub.3,
H, i-Bu, Br), (M-5370, F, CH.sub.3, H, i-Bu, CH.sub.3), (M-5371, F,
CH.sub.3, H, sec-Bu, H), (M-5372, F, CH.sub.3, H, sec-Bu, Cl),
(M-5373, F, CH.sub.3, H, sec-Bu, F), (M-5374, F, CH.sub.3, H,
sec-Bu, CF.sub.3), (M-5375, F, CH.sub.3, H, sec-Bu, Br), (M-5376,
F, CH.sub.3, H, sec-Bu, CH.sub.3), (M-5377, F, CH.sub.3, H, n-Pen,
H), (M-5378, F, CH.sub.3, H, n-Pen, Cl), (M-5379, F, CH.sub.3, H,
n-Pen, F), (M-5380, F, CH.sub.3, H, n-Pen, CF.sub.3), (M-5381, F,
CH.sub.3, H, n-Pen, Br), (M-5382, F, CH.sub.3, H, n-Pen, CH.sub.3),
(M-5383, F, CH.sub.3, H, c-Pen, H), (M-5384, F, CH.sub.3, H, c-Pen,
Cl), (M-5385, F, CH.sub.3, H, c-Pen, F), (M-5386, F, CH.sub.3, H,
c-Pen, CF.sub.3), (M-5387, F, CH.sub.3, H, c-Pen, Br), (M-5388, F,
CH.sub.3, H, c-Pen, CH.sub.3), (M-5389, F, CH.sub.3, H, n-Hex, H),
(M-5390, F, CH.sub.3, H, n-Hex, Cl), (M-5391, F, CH.sub.3, H,
n-Hex, F), (M-5392, F, CH.sub.3, H, n-Hex, CF.sub.3), (M-5393, F,
CH.sub.3, H, n-Hex, Br), (M-5394, F, CH.sub.3, H, n-Hex, CH.sub.3),
(M-5395, F, CH.sub.3, H, c-Hex, H), (M-5396, F, CH.sub.3, H, c-Hex,
Cl), (M-5397, F, CH.sub.3, H, c-Hex, F), (M-5398, F, CH.sub.3, H,
c-Hex, CF.sub.3), (M-5399, F, CH.sub.3, H, c-Hex, Br), (M-5400, F,
CH.sub.3, H, c-Hex, CH.sub.3), (M-5401, F, CH.sub.3, H, OH, H),
(M-5402, F, CH.sub.3, H, OH, Cl), (M-5403, F, CH.sub.3, H, OH, F),
(M-5404, F, CH.sub.3, H, OH, CF.sub.3), (M-5405, F, CH.sub.3, H,
OH, Br), (M-5406, F, CH.sub.3, H, OH, CH.sub.3), (M-5407, F,
CH.sub.3, H, EtO, H), (M-5408, F, CH.sub.3, H, EtO, Cl), (M-5409,
F, CH.sub.3, H, EtO, F), (M-5410, F, CH.sub.3, H, EtO, CF.sub.3),
(M-5411, F, CH.sub.3, H, EtO, Br), (M-5412, F, CH.sub.3, H, EtO,
CH.sub.3), (M-5413, F, CH.sub.3, H, n-PrO, H), (M-5414, F,
CH.sub.3, H, n-PrO, Cl), (M-5415, F, CH.sub.3, H, n-PrO, F),
(M-5416, F, CH.sub.3, H, n-PrO, CF.sub.3), (M-5417, F, CH.sub.3, H,
n-PrO, Br), (M-5418, F, CH.sub.3, H, n-PrO, CH.sub.3), (M-5419, F,
CH.sub.3, H, PhO, H), (M-5420, F, CH.sub.3, H, PhO, Cl), (M-5421,
F, CH.sub.3, H, PhO, F), (M-5422, F, CH.sub.3, H, PhO, CF.sub.3),
(M-5423, F, CH.sub.3, H, PhO, Br), (M-5424, F, CH.sub.3, H, PhO,
CH.sub.3), (M-5425, F, CH.sub.3, H, BnO, H), (M-5426, F, CH.sub.3,
H, BnO, Cl), (M-5427, F, CH.sub.3, H, BnO, F), (M-5428, F,
CH.sub.3, H, BnO, CF.sub.3), (M-5429, F, CH.sub.3, H, BnO, Br),
(M-5430, F, CH.sub.3, H, BnO, CH.sub.3), (M-5431, F, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, H), (M-5432, F, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, Cl), (M-5433, F, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, F), (M-5434, F, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-5435, F, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, Br), (M-5436, F, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-5437, F, CH.sub.3, H, CF.sub.3O,
H), (M-5438, F, CH.sub.3, H, CF.sub.3O, Cl), (M-5439, F, CH.sub.3,
H, CF.sub.3O, F), (M-5440, F, CH.sub.3, H, CF.sub.3O, CF.sub.3),
(M-5441, F, CH.sub.3, H, CF.sub.3O, Br), (M-5442, F, CH.sub.3, H,
CF.sub.3O, CH.sub.3), (M-5443, F, CH.sub.3, H, Ph, H), (M-5444, F,
CH.sub.3, H, Ph, Cl), (M-5445, F, CH.sub.3, H, Ph, F), (M-5446, F,
CH.sub.3, H, Ph, CF.sub.3), (M-5447, F, CH.sub.3, H, Ph, Br),
(M-5448, F, CH.sub.3, H, Ph, CH.sub.3), (M-5449, F, CH.sub.3, H,
4-F-Ph, H), (M-5450, F, CH.sub.3, H, 4-F-Ph, Cl), (M-5451, F,
CH.sub.3, H, 4-F-Ph, F), (M-5452, F, CH.sub.3, H, 4-F-Ph,
CF.sub.3), (M-5453, F, CH.sub.3, H, 4-F-Ph, Br), (M-5454, F,
CH.sub.3, H, 4-F-Ph, CH.sub.3), (M-5455, F, CH.sub.3, H,
4-CF.sub.3-Ph, H), (M-5456, F, CH.sub.3, H, 4-CF.sub.3-Ph, Cl),
(M-5457, F, CH.sub.3, H, 4-CF.sub.3-Ph, F), (M-5458, F, CH.sub.3,
H, 4-CF.sub.3-Ph, CF.sub.3), (M-5459, F, CH.sub.3, H,
4-CF.sub.3-Ph, Br), (M-5460, F, CH.sub.3, H, 4-CF.sub.3-Ph,
CH.sub.3), (M-5461, F, CH.sub.3, H, 4-(Me).sub.2N-Ph, H), (M-5462,
F, CH.sub.3, H, 4-(Me).sub.2N-Ph, Cl), (M-5463, F, CH.sub.3, H,
4-(Me).sub.2N-Ph, F), (M-5464, F, CH.sub.3, H, 4-(Me).sub.2N-Ph,
CF.sub.3), (M-5465, F, CH.sub.3, H, 4-(Me).sub.2N-Ph, Br), (M-5466,
F, CH.sub.3, H, 4-(Me).sub.2N-Ph, CH.sub.3), (M-5467, F, CH.sub.3,
H, 4-OH-Ph, H), (M-5468, F, CH.sub.3, H, 4-OH-Ph, Cl), (M-5469, F,
CH.sub.3, H, 4-OH-Ph, F), (M-5470, F, CH.sub.3, H, 4-OH-Ph,
CF.sub.3), (M-5471, F, CH.sub.3, H, 4-OH-Ph, Br), (M-5472, F,
CH.sub.3, H, 4-OH-Ph, CH.sub.3), (M-5473, F, CH.sub.3, H,
3,4-di-F-Ph, H), (M-5474, F, CH.sub.3, H, 3,4-di-F-Ph, Cl),
(M-5475, F, CH.sub.3, H, 3,4-di-F-Ph, F), (M-5476, F, CH.sub.3, H,
3,4-di-F-Ph, CF.sub.3), (M-5477, F, CH.sub.3, H, 3,4-di-F-Ph, Br),
(M-5478, F, CH.sub.3, H, 3,4-di-F-Ph, CH.sub.3), (M-5479, F,
CH.sub.3, H, 4-COOH-Ph, H), (M-5480, F, CH.sub.3, H, 4-COOH-Ph,
Cl), (M-5481, F, CH.sub.3, H, 4-COOH-Ph, F), (M-5482, F, CH.sub.3,
H, 4-COOH-Ph, CF.sub.3), (M-5483, F, CH.sub.3, H, 4-COOH-Ph, Br),
(M-5484, F, CH.sub.3, H, 4-COOH-Ph, CH.sub.3), (M-5485, F,
CH.sub.3, H, Bn, H), (M-5486, F, CH.sub.3, H, Bn, Cl), (M-5487, F,
CH.sub.3, H, Bn, F), (M-5488, F, CH.sub.3, H, Bn, CF.sub.3),
(M-5489, F, CH.sub.3, H, Bn, Br), (M-5490, F, CH.sub.3, H, Bn,
CH.sub.3), (M-5491, F, CH.sub.3, H, 4-F-Bn, H), (M-5492, F,
CH.sub.3, H, 4-F-Bn, Cl), (M-5493, F, CH.sub.3, H, 4-F-Bn, F),
(M-5494, F, CH.sub.3, H, 4-F-Bn, CF.sub.3), (M-5495, F, CH.sub.3,
H, 4-F-Bu, Br), (M-5496, F, CH.sub.3, H, 4-F-Bn, CH.sub.3),
(M-5497, F, CH.sub.3, H, 2-Py, H), (M-5498, F, CH.sub.3, H, 2-Py,
Cl), (M-5499, F, CH.sub.3, H, 2-Py, F), (M-5500, F, CH.sub.3, H,
2-Py, CF.sub.3), (M-5501, F, CH.sub.3, H, 2-Py, Br), (M-5502, F,
CH.sub.3, H, 2-Py, CH.sub.3), (M-5503, F, CH.sub.3, H, 3-Py, H),
(M-5504, F, CH.sub.3, H, 3-Py, Cl), (M-5505, F, CH.sub.3, H, 3-Py,
F), (M-5506, F, CH.sub.3, H, 3-Py, CF.sub.3), (M-5507, F, CH.sub.3,
H, 3-Py, Br), (M-5508, F, CH.sub.3, H, 3-Py, CH.sub.3), (M-5509, F,
CH.sub.3, H, 4-Py, H), (M-5510, F, CH.sub.3, H, 4-Py, Cl), (M-5511,
F, CH.sub.3, H, 4-Py, F), (M-5512, F, CH.sub.3, H, 4-Py, CF.sub.3),
(M-5513, F, CH.sub.3, H, 4-Py, Br), (M-5514, F, CH.sub.3, H, 4-Py,
CH.sub.3), (M-5515, F, CH.sub.3, H, 2-Th, H), (M-5516, F, CH.sub.3,
H, 2-Th, Cl), (M-5517, F, CH.sub.3, H, 2-Th, F), (M-5518, F,
CH.sub.3, H, 2-Th, CF.sub.3), (M-5519, F, CH.sub.3, H, 2-Th, Br),
(M-5520, F, CH.sub.3, H, 2-Th, CH.sub.3), (M-5521, F, CH.sub.3, H,
3-Th, H), (M-5522, F, CH.sub.3, H, 3-Th, Cl), (M-5523, F, CH.sub.3,
H, 3-Th, F), (M-5524, F, CH.sub.3, H, 3-Th, CF.sub.3), (M-5525, F,
CH.sub.3, H, 3-Th, Br), (M-5526, F, CH.sub.3, H, 3-Th, CH.sub.3),
(M-5527, F, CH.sub.3, H, pyrrazol-2-yl, H), (M- 5528, F, CH.sub.3,
H, pyrrazol-2-yl, Cl), (M-5529, F, CH.sub.3, H, pyrrazol-2-yl, F),
(M-5530, F, CH.sub.3, H, pyrrazol-2-yl, CF.sub.3), (M-5531, F,
CH.sub.3, H, pyrrazol-2-yl, Br), (M-5532, F, CH.sub.3, H,
pyrrazol-2-yl, CH.sub.3), (M-5533, F, CH.sub.3, H, pyrrazol-3-yl,
H), (M-5534, F, CH.sub.3, H, pyrrazol-3-yl, Cl), (M-5535, F,
CH.sub.3, H, pyrrazol-3-yl, F), (M-5536, F, CH.sub.3, H,
pyrrazol-3-yl, CF.sub.3), (M-5537, F, CH.sub.3, H, pyrrazol-3-yl,
Br), (M-5538, F, CH.sub.3, H, pyrrazol-3-yl, CH.sub.3), (M-5539, F,
CH.sub.3, H, pyrimidin-2-yl, H), (M-5540, F, CH.sub.3, H,
pyrimidin-2-yl, Cl), (M-5541, F, CH.sub.3, H, pyrimidin-2-yl, F),
(M-5542, F, CH.sub.3, H, pyrimidin-2-yl, CF.sub.3), (M-5543, F,
CH.sub.3, H, pyrimidin-2-yl, Br), (M-5544, F, CH.sub.3, H,
pyrimidin-2-yl, CH.sub.3), (M-5545, F, CH.sub.3, H, pyrimidin-4-yl,
H), (M-5546, F, CH.sub.3, H, pyrimidin-4-yl, Cl), (M-5547, F,
CH.sub.3, H, pyrimidin-4-yl, F), (M-5548, F, CH.sub.3, H,
pyrimidin-4-yl, CF.sub.3), (M-5549, F, CH.sub.3, H, pyrimidin-4-yl,
Br), (M-5550, F, CH.sub.3, H, pyrimidin-4-yl, CH.sub.3), (M-5551,
F, CH.sub.3, H, pyrimidin-5-yl, H), (M-5552, F, CH.sub.3, H,
pyrimidin-5-yl, Cl), (M-5553, F, CH.sub.3, H, pyrimidin-5-yl, F),
(M-5554, F, CH.sub.3, H, pyrimidin-5-yl, CF.sub.3), (M-5555, F,
CH.sub.3, H, pyrimidin-5-yl, Br), (M-5556, F, CH.sub.3, H,
pyrimidin-5-yl, CH.sub.3), (M-5557, F, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-5558, F, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2Cl), (M-5559, F, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-5560, F, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-5561, F, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-5562, F, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-5563, F, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5564, F, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-5565, F, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5566, F, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-5567, F,
CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-5568, F,
CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-5569, F, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5570, F,
CH.sub.3, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-5571, F, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5572, F,
CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-5573, F,
CH.sub.3, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-5574, F, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-6575,
F, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5676,
F, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-5577,
F, CH.sub.3, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3, F), (M-5578, F, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-5579, F, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-5580, F, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3),
(M-5581, F, CH.sub.3, H, MeOCH.sub.2, H), (M-5582, F, CH.sub.3, H,
MeOCH.sub.2, Cl), (M-5583, F, CH.sub.3, H, MeOCH.sub.2, F),
(M-5584, F, CH.sub.3, H, MeOCH.sub.2, CH.sub.3), (M-5585, F,
CH.sub.3, H, MeOCH.sub.2, Br), (M-5586, F, CH.sub.3, H,
MeOCH.sub.2, CH.sub.3), (M-5587, F, CH.sub.3, H, EtOCH.sub.2, H),
(M-5588, F, CH.sub.3, H, EtOCH.sub.2, Cl), (M-5589, F, CH.sub.3, H,
EtOCH.sub.2, F), (M-5590, F, CH.sub.3, H, EtOCH.sub.2, CF.sub.3),
(M-5591, F, CH.sub.3, H, EtOCH.sub.2, Br), (M-5592, F, CH.sub.3, H,
EtOCH.sub.2, CH.sub.3), (M-5593, F, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, H), (M-5594, F, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, Cl), (M-5595, F, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, F), (M-5596, F, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-5597, F, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, Br), (M-5598, F, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-5599, F, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-5600, F, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-5601, F, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-5602, F, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-5603, F,
CH.sub.3, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-5604, F,
CH.sub.3, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-5605, F, CH.sub.3, H, MeOCH.sub.2CH.sub.2, H), (M-5606, F,
CH.sub.3, H, MeOCH.sub.2CH.sub.2, Cl), (M-5607, F, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, F), (M-5608, F, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-5609, F, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, Br), (M-5610, F, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-5611, F, CH.sub.3, H,
HOCH.sub.2, H), (M-5612, F, CH.sub.3, H, HOCH.sub.2, Cl), (M-5613,
F, CH.sub.3, H, HOCH.sub.2, F), (M-5614, F, CH.sub.3, H,
HOCH.sub.2, CF.sub.3), (M-5615, F, CH.sub.3, H, HOCH.sub.2, Br),
(M-5616, F, CH.sub.3, H, HOCH.sub.2, CH.sub.3), (M-5617, F,
CH.sub.3, H, HOCH.sub.2CH.sub.2, H), (M-5618, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2, Cl), (M-5619, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2, F), (M-5620, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-5621, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2, Br), (M-5622, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-5623, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-5624, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-5625, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-6626, F, CH.sub.3, H,
HOCH.sub.2CH
.sub.2CH.sub.2, CF.sub.3), (M-5627, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-5628, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-5629, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5630, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-5631, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5632, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-5633, F,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-5634, F,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-5635, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5636, F,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl),
(M-5637, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5638, F,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-5639, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-5640, F,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3),
(M-5641, F, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H),
(M-6642, F, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-5643, F, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-5644, F, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CF.sub.3), (M-5645, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-5646, F, CH.sub.3, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-5647, F,
CH.sub.3, H, (Me).sub.2N, H), (M-5648, F, CH.sub.3, H, (Me).sub.2N,
Cl), (M-5649, F, CH.sub.3, H, (Me).sub.2N, F), (M-5650, F,
CH.sub.3, H, (Me).sub.2N, CF.sub.3), (M-5651, F, CH.sub.3, H,
(Me).sub.2N, Br), (M-5652, F, CH.sub.3, H, (Me).sub.2N, CH.sub.3),
(M-5653, F, CH.sub.3, H, piperidin-4-yl-methyl, H), (M-5654, F,
CH.sub.3, H, piperidin-4-yl-methyl, Cl), (M-5655, F, CH.sub.3, H,
piperidin-4-yl-methyl, F), (M-5656, F, CH.sub.3, H,
piperidin-4-yl-methyl, CF.sub.3), (M-5657, F, CH.sub.3, H,
piperidin-4-yl-methyl, Br), (M-5658, F, CH.sub.3, H,
piperidin-4-yl-methyl, CH.sub.3), (M-5659, F, CH.sub.3, H,
cyclohexylmethyl, H), (M-5660, F, CH.sub.3, H, cyclohexylmethyl,
Cl), (M-5661, F, CH.sub.3, H, cyclohexylmethyl, F), (M-5662, F,
CH.sub.3, H, cyclohexylmethyl, CF.sub.3), (M-5663, F, CH.sub.3, H,
cyclohexylmethyl, Br), (M-5664, F, CH.sub.3, H, cyclohexylmethyl,
CH.sub.3), (M-5665, F, CH.sub.3, F, H, H), (M-5666, F, CH.sub.3, F,
H, Cl), (M-5667, F, CH.sub.3, F, H, F), (M-5668, F, CH.sub.3, F, H,
CF.sub.3), (M-5669, F, CH.sub.3, F, H, Br), (M-5670, F, CH.sub.3,
F, H, CH.sub.3), (M-5671, F, CH.sub.3, F, F, H), (M-5672, F,
CH.sub.3, F, F, Cl), (M-5673, F, CH.sub.3, F, F, F), (M-5674, F,
CH.sub.3, F, F, CF.sub.3), (M-5675, F, CH.sub.3, F, F, Br),
(M-5676, F, CH.sub.3, F, F, CH.sub.3), (M-5677, F, CH.sub.3, F, Cl,
H), (M-5678, F, CH.sub.3, F, Cl, Cl), (M-5679, F, CH.sub.3, F, Cl,
F), (M-5680, F, CH.sub.3, F, Cl, CF.sub.3), (M-6681, F, CH.sub.3,
F, Cl, Br), (M-5682, F, CH.sub.3, F, Cl, CH.sub.3), (M-5683, F,
CH.sub.3, F, CH.sub.3, H), (M-5684, F, CH.sub.3, F, CH.sub.3, Cl),
(M-5685, F, CH.sub.3, F, CH.sub.3, F), (M-5686, F, CH.sub.3, F,
CH.sub.3, CF.sub.3), (M-5687, F, CH.sub.3, F, CH.sub.3, Br),
(M-5688, F, CH.sub.3, F, CH.sub.3, CH.sub.3), (M-5689, F, CH.sub.3,
F, Et, H), (M-5690, F, CH.sub.3, F, Et, Cl), (M-5691, F, CH.sub.3,
F, Et, F), (M-5692, F, CH.sub.3, F, Et, CF.sub.3), (M-5693, F,
CH.sub.3, F, Et, Br), (M-5694, F, CH.sub.3, F, Et, CH.sub.3),
(M-5695, F, CH.sub.3, F, n-Pr, H), (M-5696, F, CH.sub.3, F, n-Pr,
Cl), (M-5697, F, CH.sub.3, F, n-Pr, F), (M-5698, F, CH.sub.3, F,
n-Pr, CF.sub.3), (M-5699, F, CH.sub.3, F, n-Pr, Br), (M-5700, F,
CH.sub.3, F, n-Pr, CH.sub.3), (M-5701, F, CH.sub.3, F, c-Pr, H),
(M-5702, F, CH.sub.3, F, c-Pr, Cl), (M-5703, F, CH.sub.3, F, c-Pr,
F), (M-5704, F, CH.sub.3, F, c-Pr, CF.sub.3), (M-5705, F, CH.sub.3,
F, c-Pr, Br), (M-5706, F, CH.sub.3, F, c-Pr, CH.sub.3), (M-5707, F,
CH.sub.3, F, i-Pr, H), (M-5708, F, CH.sub.3, F, i-Pr, Cl), (M-5709,
F, CH.sub.3, F, i-Pr, F), (M-5710, F, CH.sub.3, F, i-Pr, CF.sub.3),
(M-5711, F, CH.sub.3, F, i-Pr, Br), (M-5712, F, CH.sub.3, F, i-Pr,
CH.sub.3), (M-5713, F, CH.sub.3, F, n-Bu, H), (M-5714, F, CH.sub.3,
F, n-Bu, Cl), (M-5715, F, CH.sub.3, F, n-Bu, F), (M-5716, F,
CH.sub.3, F, n-Bu, CF.sub.3), (M-5717, F, CH.sub.3, F, n-Bu, Br),
(M-5718, F, CH.sub.3, F, n-Bu, CH.sub.3), (M-5719, F, CH.sub.3, F,
i-Bu, H), (M-5720, F, CH.sub.3, F, i-Bu, Cl), (M-5721, F, CH.sub.3,
F, i-Bu, F), (M-5722, F, CH.sub.3, F, i-Bu, CF.sub.3), (M-5723, F,
CH.sub.3, F, i-Bu, Br), (M-5724, F, CH.sub.3, F, i-Bu, CH.sub.3),
(M-5725, F, CH.sub.3, F, sec-Bu, H), (M-5726, F, CH.sub.3, F,
sec-Bu, Cl), (M-5727, F, CH.sub.3, F, sec-Bu, F), (M-5728, F,
CH.sub.3, F, sec-Bu, CF.sub.3), (M-5729, F, CH.sub.3, F, sec-Bu,
Br), (M-5730, F, CH.sub.3, F, sec-Bu, CH.sub.3), (M-5731, F,
CH.sub.3, F, n-Pea, H), (M-5732, F, CH.sub.3, F, n-Pen, Cl),
(M-5733, F, CH.sub.3, F, n-Pen, F), (M-5734, F, CH.sub.3, F, n-Pen,
CF.sub.3), (M-5735, F, CH.sub.3, F, n-Pen, Br), (M-5736, F,
CH.sub.3, F, n-Pen, CH.sub.3), (M-5737, F, CH.sub.3, F, c-Pen, H),
(M-5738, F, CH.sub.3, F, c-Pen, Cl), (M-5739, F, CH.sub.3, F,
c-Pen, F), (M-5740, F, CH.sub.3, F, c-Pen, CF.sub.3), (M-5741, F,
CH.sub.3, F, c-Pen, Br), (M-5742, F, CH.sub.3, F, c-Pen, CH.sub.3),
(M-5743, F, CH.sub.3, F, n-Hex, H), (M-5744, F, CH.sub.3, F, n-Hex,
Cl), (M-5745, F, CH.sub.3, F, n-Hex, F), (M-5746, F, CH.sub.3, F,
n-Hex, CF.sub.3), (M-5747, F, CH.sub.3, F, n-Hex, Br), (M-5748, F,
CH.sub.3, F, n-Hex, CH.sub.3), (M-5749, F, CH.sub.3, F, c-Hex, H),
(M-5750, F, CH.sub.3, F, c-Hex, Cl), (M-5751, F, CH.sub.3, F,
c-Hex, F), (M-5752, F, CH.sub.3, F, c-Hex, CF.sub.3), (M-5753, F,
CH.sub.3, F, c-Hex, Br), (M-5754, F, CH.sub.3, F, c-Hex, CH.sub.3),
(M-5755, F, CH.sub.3, F, OH, H), (M-5756, F, CH.sub.3, F, OH, Cl,
(M-5757, F, CH.sub.3, F, OH, F), (M-5758, F, CH.sub.3, F, OH,
CF.sub.3), (M-5759, F, CH.sub.3, F, OH, Br), (M-5760, F, CH.sub.3,
F, OH, CH.sub.3), (M-5761, F, CH.sub.3, F, EtO, H), (M-5762, F,
CH.sub.3, F, EtO, Cl), (M-5763, F, CH.sub.3, F, EtO, F), (M-5764,
F, CH.sub.3, F, EtO, CF.sub.3), (M-5765, F, CH.sub.3, F, EtO, Br),
(M-5766, F, CH.sub.3, F, EtO, CH.sub.3), (M-5767, F, CH.sub.3, F,
n-PrO, H), (M-5768, F, CH.sub.3, F, n-PrO, Cl), (M-5769, F,
CH.sub.3, F, n-PrO, F), (M-5770, F, CH.sub.3, F, n-PrO, CF.sub.3),
(M-5771, F, CH.sub.3, F, n-PrO, Br), (M-5772, F, CH.sub.3, F,
n-PrO, CH.sub.3), (M-5773, F, CH.sub.3, F, PhO, H), (M-5774, F,
CH.sub.3, F, PhO, Cl), (M-5775, F, CH.sub.3, F, PhO, F), (M-5776,
F, CH.sub.3, F, PhO, CF.sub.3), (M-5777, F, CH.sub.3, F, PhO, Br),
(M-5778, F, CH.sub.3, F, PhO, CH.sub.3), (M-5779, F, CH.sub.3, F,
BnO, H), (M-5780, F, CH.sub.3, F, BnO, Cl), (M-5781, F, CH.sub.3,
F, BnO, F), (M-5782, F, CH.sub.3, F, BnO, CF.sub.3), (M-5783, F,
CH.sub.3, F, BnO, Br), (M-5784, F, CH.sub.3, F, BnO, CH.sub.3),
(M-5785, F, CH.sub.3, F, PhCH.sub.2CH.sub.2O, H), (M-5786, F,
CH.sub.3, F, PhCH.sub.2CH.sub.2O, Cl), (M-5787, F, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, F), (M-5788, F, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-5789, F, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, Br), (M-5790, F, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-5791, F, CH.sub.3, F, CF.sub.3O,
H), (M-5792, F, CH.sub.3, F, CF.sub.3O, Cl), (M-5793, F, CH.sub.3,
F, CF.sub.3O, F), (M-5794, F, CH.sub.3, F, CF.sub.3O, CF.sub.3),
(M-5795, F, CH.sub.3, F, CF.sub.3O, Br), (M-5796, F, CH.sub.3, F,
CF.sub.3O, CH.sub.3), (M-5797, F, CH.sub.3, F, Ph, H), (M-5798, F,
CH.sub.3, F, Ph, Cl), (M-5799, F, CH.sub.3, F, Ph, F), (M-5800, F,
CH.sub.3, F, Ph, CF.sub.3), (M-5801, F, CH.sub.3, F, Ph, Br),
(M-5802, F, CH.sub.3, F, Ph, CH.sub.3), (M-5803, F, CH.sub.3, F,
4-F-Ph, H), (M-5804, F, CH.sub.3, F, 4-F-Ph, Cl), (M-5805, F,
CH.sub.3, F, 4-F-Ph, F), (M-5806, F, CH.sub.3, F, 4-F-Ph,
CH.sub.3), (M-5807, F, CH.sub.3, F, 4-F-Ph, Br), (M-5808, F,
CH.sub.3, F, 4-F-Ph, CH.sub.3), (M-5809, F, CH.sub.3, F,
4-CF.sub.3-Ph, H), (M-5810, F, CH.sub.3, F, 4-CF.sub.3-Ph, Cl),
(M-5811, F, CH.sub.3, F, 4-CF.sub.3-Ph, F), (M-5812, F, CH.sub.3,
F, 4-CF.sub.3-Ph, CF.sub.3), (M-5813, F, CH.sub.3, F,
4-CF.sub.3-Ph, Br), (M-5814, F, CH.sub.3, F, 4-CF.sub.3-Ph,
CH.sub.3), (M-5815, F, CH.sub.3, F, 4-(Me).sub.2N-Ph, H), (M-5816,
F, CH.sub.3, F, 4-(Me).sub.3N-Ph, Cl), (M-5817, F, CH.sub.3, F,
4-(Me).sub.2N-Ph, F), (M-5818, F, CH.sub.3, F, 4-(Me).sub.2N-Ph,
CF.sub.3), (M-5819, F, CH.sub.3, F, 4-(Me).sub.3N-Ph, Br), (M-5820,
F, CH.sub.3, F, 4-(Me).sub.2N-Ph, CH.sub.3), (M-5821, F, CH.sub.3,
F, 4-OH-Ph, H), (M-5822, F, CH.sub.3, F, 4-OH-Ph, Cl), (M-5823, F,
CH.sub.3, F, 4-OH-Ph, F), (M-5824, F, CH.sub.3, F, 4-OH-Ph,
CH.sub.3), (M-5825, F, CH.sub.3, F, 4-OH-Ph, Br), (M-5826, F,
CH.sub.3, F, 4-OH-Ph, CH.sub.3), (M-5827, F, CH.sub.3, F,
3,4-di-F-Ph, H), (M-5828, F, CH.sub.3, F, 3,4-di-F-Ph, Cl),
(M-5829, F, CH.sub.3, F, 3,4-di-F-Ph, F), (M-5830, F, CH.sub.3, F,
3,4-di-F-Ph, CF.sub.3), (M-5831, F, CH.sub.3, F, 3,4-di-F-Ph, Br),
(M-5832, F, CH.sub.3, F, 3,4-di-F-Ph, CH.sub.3), (M-5833, F,
CH.sub.3, F, 4-COOH-Ph, H), (M-5834, F, CH.sub.3, F, 4-COOH-Ph,
Cl), (M-5835, F, CH.sub.3, F, 4-COOH-Ph, F), (M-5836, F, CH.sub.3,
F, 4-COOH-Ph, CF.sub.3), (M-5837, F, CH.sub.3, F, 4-COOH-Ph, Br),
(M-5838, F, CH.sub.3, F, 4-COOH-Ph, CH.sub.3), (M-5839, F,
CH.sub.3, F, Bu, H), (M-5840, F, CH.sub.3, F, Bn, Cl), (M-5841, F,
CH.sub.3, F, Bn, F), (M-5842, F, CH.sub.3, F, Bn, CF.sub.3),
(M-5843, F, CH.sub.3, F, Bn, Br), (M-5844, F, CH.sub.3, F, Bn,
CH.sub.3), (M-5845, F, CH.sub.3, F, 4-F-Bn, H), (M-5846, F,
CH.sub.3, F, 4-F-Bn, Cl), (M-5847, F, CH.sub.3, F, 4-F-Bn, F),
(M-5848, F, CH.sub.3, F, 4-F-Bn, CF.sub.3), (M-5849, F, CH.sub.3,
F, 4-F-Bn, Br), (M-5850, F, CH.sub.3, F, 4-F-Bn, CH.sub.3),
(M-5851, F, CH.sub.3, F, 2-Py, H), (M-5852, F, CH.sub.3, F, 2-Py,
Cl), (M-5853, F, CH.sub.3, F, 2-Py, F), (M-5854, F, CH.sub.3, F,
2-Py, CF.sub.3), (M-5855, F, CH.sub.3, F, 2-Py, Br), (M-5856, F,
CH.sub.3, F, 2-Py, CH.sub.3), (M-5857, F, CH.sub.3, F, 3-Py, H),
(M-5858, F, CH.sub.3, F, 3-Py, Cl), (M-5859, F, CH.sub.3, F, 3-Py,
F), (M-5860, F, CH.sub.3, F, 3-Py, CF.sub.3), (M-5861, F, CH.sub.3,
F, 3-Py, Br), (M-5862, F, CH.sub.3, F, 3-Py, CH.sub.3), (M-5863, F,
CH.sub.3, F, 4-Py, H), (M-5864, F, CH.sub.3, F, 4-Py, Cl), (M-5865,
F, CH.sub.3, F, 4-Py, F), (M-5866, F, CH.sub.3, F, 4-Py, CF.sub.3),
(M-5867, F, CH.sub.3, F, 4-Py, Br), (M-5868, F, CH.sub.3, F, 4-Py,
CH.sub.3), (M-5869, F, CH.sub.3, F, 2-Th, H), (M-5870, F, CH.sub.3,
F, 2-Th, Cl), (M-5871, F, CH.sub.3, F, 2-Th, F), (M-5872, F,
CH.sub.3, F, 2-Th, CF.sub.3), (M-5873, F, CH.sub.3, F, 2-Th, Br),
(M-5874, F, CH.sub.3, F, 2-Th, CH.sub.3), (M-5875, F, CH.sub.3, F,
3-Th, H), (M-5876, F, CH.sub.3, F, 3-Th, Cl), (M-5877, F, CH.sub.3,
F, 3-Th, F), (M-5878, F, CH.sub.3, F, 3-Th, CF.sub.3), (M-5879, F,
CH.sub.3, F, 3-Th, Br), (M-5880, F, CH.sub.3, F, 3-Th, CH.sub.3),
(M-5881, F, CH.sub.3, F, pyrrazol-2-yl, H), (M-5882, F, CH.sub.3,
F, pyrrazol-2-yl, Cl), (M-5883, F, CH.sub.3, F, pyrrazol-2-yl, F),
(M-5884, F, CH.sub.3, F, pyrrazol-2-yl, CF.sub.3), (M-5885, F,
CH.sub.3, F, pyrrazol-2-yl, Br), (M-5886, F, CH.sub.3, F,
pyrrazol-2-yl, CH.sub.3), (M-5887, F, CH.sub.3, F, pyrrazol-3-yl,
H), (M-5888, F, CH.sub.3, F, pyrrazol-3-yl, Cl), (M-5889, F,
CH.sub.3, F, pyrrazol-3-yl, F), (M-5890, F, CH.sub.3, F,
pyrrazol-3-yl, CF.sub.3), (M-5891, F, CH.sub.3, F, pyrrazol-3-yl,
Br), (M-5892, F, CH.sub.3, F, pyrrazol-3-yl, CH.sub.3), (M-5893, F,
CH.sub.3, F, pyrimidin-2-yl, H), (M-5894, F, CH.sub.3, F,
pyrimidin-2-yl, Cl), (M-5895, F, CH.sub.3, F, pyrimidin-2-yl, F),
(M-5896, F, CH.sub.3, F, pyrimidin-2-yl, CF.sub.3), (M-5897, F,
CH.sub.3, F, pyrimidin-2-yl, Br), (M-5898, F, CH.sub.3, F,
pyrimidin-2-yl, CH.sub.3), (M-5899, F, CH.sub.3, F, pyrimidin-4-yl,
H), (M-5900, F, CH.sub.3, F, pyrimidin-4-yl, Cl), (M-5901, F,
CH.sub.3, F, pyrimidin-4-yl, F), (M-5902, F, CH.sub.3, F,
pyrimidin-4-yl, CF.sub.3), (M-5903, F, CH.sub.3, F, pyrimidin-4-yl,
Br), (M-5904, F, CH.sub.3, F, pyrimidin-4-yl, CH.sub.3), (M-5905,
F, CH.sub.3, F, pyrimidin-5-yl, H), (M-5906, F, CH.sub.3, F,
pyrimidin-5-yl, Cl), (M-5907, F, CH.sub.3, F, pyrimidin-5-yl, F),
(M-5908, F, CH.sub.3, F, pyrimidin-5-yl, CF.sub.3), (M-5909, F,
CH.sub.3, F, pyrimidin-5-yl, Br), (M-5910, F, CH.sub.3, F,
pyrimidin-5-yl, CH.sub.3), (M-5911, F, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-5912, F, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-5913, F, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-5914, F, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-5915, F, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2Br), (M-5916, F, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-5917, F, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5918, F, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-5919, F, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5920, F, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-5921, F,
CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-5922, F,
CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-5923, F, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5924, F,
CH.sub.3, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-5925, F, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5926, F,
CH.sub.3, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-5927, F, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-5928, F,
CH.sub.3, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.3,
CH.sub.3), (M-5929, F, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-5930,
F, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-5931,
F, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5932,
F, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-5933, F, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-5934,
F, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-5935, F, CH.sub.3, F, MeOCH.sub.2, H), (M-5936, F, CH.sub.3, F,
MeOCH.sub.2, Cl), (M-5937, F, CH.sub.3, F, MeOCH.sub.2, F),
(M-5938, F, CH.sub.3, F, MeOCH.sub.2, CF.sub.3), (M-5939, F,
CH.sub.3, F, MeOCH.sub.2, Br), (M-5940, F, CH.sub.3, F,
MeOCH.sub.2, CH.sub.3), (M-5941, F, CH.sub.3, F, EtOCH.sub.2, H),
(M-5942, F, CH.sub.3, F, EtOCH.sub.2, Cl), (M-5943, F, CH.sub.3, F,
EtOCH.sub.2, F), (M-5944, F, CH.sub.3, F, EtOCH.sub.2, CF.sub.3),
(M-5945, F, CH.sub.3, F, EtOCH.sub.2, Br), (M-5946, F, CH.sub.3, F,
EtOCH.sub.2, CH.sub.3), (M-5947, F, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, H), (M-5948, F, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, Cl), (M-5949, F, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, F), (M-5950, F, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-5951, F, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, Br), (M-5952, F, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-5953, F, CH.sub.3, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-5954, F, CH.sub.3, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-5955, F, CH.sub.3, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-5956, F, CH
.sub.3, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-5957, F, CH.sub.3, F, MeOCH.sub.2CH.sub.2CH.sub.2CH.sub.3, Br),
(M-5958, F, CH.sub.3, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-5959, F, CH.sub.3, F, MeOCH.sub.2CH.sub.2, H),
(M-5960, F, CH.sub.3, F, MeOCH.sub.2CH.sub.2, Cl), (M-5961, F,
CH.sub.3, F, MeOCH.sub.2CH.sub.2, F), (M-5962, F, CH.sub.3, F,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-5963, F, CH.sub.3, F,
MeOCH.sub.2CH.sub.2, Br), (M-5964, F, CH.sub.3, F,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-5965, F, CH.sub.3, F,
HOCH.sub.2, H), (M-5966, F, CH.sub.3, F, HOCH.sub.2, Cl), (M-5967,
F, CH.sub.3, F, HOCH.sub.2, F), (M-5968, F, CH.sub.3, F,
HOCH.sub.2, CF.sub.3), (M-5969, F, CH.sub.3, F, HOCH.sub.2, Br),
(M-5970, F, CH.sub.3, F, HOCH.sub.2, CH.sub.3), (M-5971, F,
CH.sub.3, F, HOCH.sub.2CH.sub.2, H), (M-5972, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2, Cl), (M-5973, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2, F), (M-5974, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-5975, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2, Br), (M-5976, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-5977, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-5978, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-5979, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-5980, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-5981, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-5982, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-5983, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5984, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-5985, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5986, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-5987, F,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-5988, F,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-5989, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-5990, F,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl),
(M-5991, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-5992, F,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-5993, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-5994, F,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3),
(M-5995, F, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H),
(M-5996, F, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-5997, F, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-5998, F, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CF.sub.3), (M-5999, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-6000, F, CH.sub.3, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-6001, F,
CH.sub.3, F, (Me).sub.2N, H), (M-6002, F, CH.sub.3, F, (Me).sub.2N,
Cl), (M-6003, F, CH.sub.3, F, (Me).sub.2N, F), (M-6004, F,
CH.sub.3, F, (Me).sub.2N, CF.sub.3), (M-6005, F, CH.sub.3, F,
(Me).sub.2N, Br), (M-6006, F, CH.sub.3, F, (Me).sub.2N, CH.sub.3),
(M-6007, F, CH.sub.3, F, piperidin-4-yl-methyl, H), (M-6008, F,
CH.sub.3, F, piperidin-4-yl-methyl, Cl), (M-6009, F, CH.sub.3, F,
piperidin-4-yl-methyl, F), (M-6010, F, CH.sub.3, F,
piperidin-4-yl-methyl, CF.sub.3), (M-6011, F, CH.sub.3, F,
piperidin-4-yl-methyl, Br), (M-6012, F, CH.sub.3, F,
piperidin-4-yl-methyl, CH.sub.3), (M-6013, F, CH.sub.3, F,
cyclohexylmethyl, H), (M-6014, F, CH.sub.3, F, cyclohexylmethyl,
Cl), (M-6015, F, CH.sub.3, F, cyclohexylmethyl, F), (M-6016, F,
CH.sub.3, F, cyclohexylmethyl, CF.sub.3), (M-6017, F, CH.sub.3, F,
cyclohexylmethyl, Br), (M-6018, F, CH.sub.3, F, cyclohexylmethyl,
CH.sub.3), (M-6019, F, CH.sub.3, Cl, H, H), (M-6020, F, CH.sub.3,
Cl, H, Cl), (M-6021, F, CH.sub.3, Cl, H, F), (M-6022, F, CH.sub.3,
Cl, H, CF.sub.3), (M-6023, F, CH.sub.3, Cl, H, Br), (M-6024, F,
CH.sub.3, Cl, H, CH.sub.3), (M-6025, F, CH.sub.3, Cl, F, H),
(M-6026, F, CH.sub.3, Cl, F, Cl), (M-6027, F, CH.sub.3, Cl, F, F),
(M-6028, F, CH.sub.3, Cl, F, CF.sub.3), (M-6029, F, CH.sub.3, Cl,
F, Br), (M-6030, F, CH.sub.3, Cl, F, CH.sub.3), (M-6031, F,
CH.sub.3, Cl, Cl, H), (M-6032, F, CH.sub.3, Cl, Cl, Cl), (M-6033,
F, CH.sub.3, Cl, Cl, F), (M-6034, F, CH.sub.3, Cl, Cl, CF.sub.3),
(M-6035, F, CH.sub.3, Cl, Cl, Br), (M-6036, F, CH.sub.3, Cl, Cl,
CH.sub.3), (M-6037, F, CH.sub.3, Cl, CH.sub.3, H), (M-6038, F,
CH.sub.31 Cl, CH.sub.3, Cl), (M-6039, F, CH.sub.3, Cl, CH.sub.3,
F), (M-6040, F, CH.sub.3, Cl, CH.sub.3, CF.sub.3), (M-6041, F,
CH.sub.3, Cl, CH.sub.3, Br), (M-6042, F, CH.sub.3, Cl, CH.sub.3,
CH.sub.3), (M-6043, F, CH.sub.3, Cl, Et, H), (M-6044, F, CH.sub.3,
Cl, Et, Cl), (M-6045, F, CH.sub.3, Cl, Et, F), (M-6046, F,
CH.sub.3, Cl, Et, CF.sub.3), (M-6047, F, CH.sub.3, Cl, Et, Br),
(M-6048, F, CH.sub.3, Cl, Et, CH.sub.3), (M-6049, F, CH.sub.3, Cl,
n-Pr, H), (M-6050, F, CH.sub.3, Cl, n-Pr, Cl), (M-6051, F,
CH.sub.3, Cl, n-Pr, F), (M-6052, F, CH.sub.3, Cl, n-Pr, CF.sub.3),
(M-6053, F, CH.sub.3, Cl, n-Pr, Br), (M-6054, F, CH.sub.3, Cl,
n-Pr, CH.sub.3), (M-6055, F, CH.sub.3, Cl, c-Pr, H), (M-6056, F,
CH.sub.3, Cl, c-Pr, Cl), (M-6057, F, CH.sub.3, Cl, c-Pr, F),
(M-6058, F, CH.sub.3, Cl, c-Pr, CF.sub.3), (M-6059, F, CH.sub.3,
Cl, c-Pr, Br), (M-6060, F, CH.sub.3, Cl, c-Pr, CH.sub.3), (M-6061,
F, CH.sub.3, Cl, i-Pr, H), (M-6062, F, CH.sub.3, Cl, i-Pr, Cl),
(M-6063, F, CH.sub.3, Cl, i-Pr, F), (M-6064, F, CH.sub.3, Cl, i-Pr,
CF.sub.3), (M-6065, F, CH.sub.3, Cl, i-Pr, Br), (M-6066, F,
CH.sub.3, Cl, i-Pr, CH.sub.3), (M-6067, F, CH.sub.3, Cl, n-Bu, H),
(M-6068, F, CH.sub.3, Cl, n-Bu, Cl), (M-6069, F, CH.sub.3, Cl,
n-Bu, F), (M-6070, F, CH.sub.3, Cl, n-Bu, CF.sub.3), (M-6071, F,
CH.sub.3, Cl, n-Bu, Br), (M-6072, F, CH.sub.3, Cl, n-Bu, CH.sub.3),
(M-6073, F, CH.sub.3, Cl, i-Bu, H), (M-6074, F, CH.sub.3, Cl, i-Bu,
Cl), (M-6075, F, CH.sub.3, Cl, i-Bu, F), (M-6076, F, CH.sub.3, Cl,
i-Bu, CF.sub.3), (M-6077, F, CH.sub.3, Cl, i-Bu, Br), (M-6078, F,
CH.sub.3, Cl, i-Bu, CH.sub.3), (M-6079, F, CH.sub.3, Cl, sec-Bu,
H), (M-6080, F, CH.sub.3, Cl, sec-Bu, Cl), (M-6081, F, CH.sub.3,
Cl, sec-Bu, F), (M-6082, F, CH.sub.3, Cl, sec-Bu, CF.sub.3),
(M-6083, F, CH.sub.3, Cl, sec-Bu, Br), (M-6084, F, CH.sub.3, Cl,
sec-Bu, CH.sub.3), (M-6085, F, CH.sub.3, Cl, n-Pen, H), (M-6086, F,
CH.sub.3, Cl, n-Pen, Cl), (M-6087, F, CH.sub.3, Cl, n-Pen, F),
(M-6088, F, CH.sub.3, Cl, n-Pen, CF.sub.3), (M-6089, F, CH.sub.3,
Cl, n-Pen, Br), (M-6090, F, CH.sub.3, Cl, n-Pen, CH.sub.3),
(M-6091, F, CH.sub.3, Cl, c-Pen, H), (M-6092, F, CH.sub.3, Cl,
c-Pen, Cl), (M-6093, F, CH.sub.3, Cl, c-Pen, F), (M-6094, F,
CH.sub.3, Cl, c-Pen, CF.sub.3), (M-6095, F, CH.sub.3, Cl, c-Pen,
Br), (M-6096, F, CH.sub.3, Cl, c-Pen, CH.sub.3), (M-6097, F,
CH.sub.3, Cl, n-Hex, H), (M-6098, F, CH.sub.3, Cl, n-Hex, Cl),
(M-6099, F, CH.sub.3, Cl, n-Hex, F), (M-6100, F, CH.sub.3, Cl,
n-Hex, CF.sub.3), (M-6101, F, CH.sub.3, CL n-Hex, Br), (M-6102, F,
CH.sub.3, Cl, n-Hex, CH.sub.3), (M-6103, F, CH.sub.3, Cl, c-Hex,
H), (M-6104, F, CH.sub.3, Cl, c-Hex, Cl), (M-6105, F, CH.sub.3, Cl,
c-Hex, F), (M-6106, F, CH.sub.3, Cl, c-Hex, CF.sub.3), (M-6107, F,
CH.sub.3, Cl, c-Hex, Br), (M-6108, F, CH.sub.3, Cl, c-Hex,
CH.sub.3), (M-6109, F, CH.sub.3, Cl, Oil, H), (M-6110, F, CH.sub.3,
Cl, OH, Cl), (M-6111, F, CH.sub.3, Cl, OH, F), (M-6112, F,
CH.sub.3, Cl, OH, CF.sub.3), (M-6113, F, CH.sub.3, Cl, OH, Br),
(M-6114, F, CH.sub.3, Cl, OH, CH.sub.3), (M-6115, F, CH.sub.3, Cl,
EtO, H), (M-6116, F, CH.sub.3, Cl, EtO, Cl), (M-6117, F, CH.sub.3,
Cl, EtO, F), (M-6118, F, CH.sub.3, Cl, EtO, CF.sub.3), (M-6119, F,
CH.sub.3, Cl, EtO, Br), (M-6120, F, CH.sub.3, Cl, EtO, CH.sub.3),
(M-6121, F, CH.sub.3, Cl, n-PrO, H), (M-6122, F, CH.sub.3, Cl,
n-PrO, Cl), (M-6123, F, CH.sub.3, Cl, n-PrO, F), (M-6124, F,
CH.sub.3, Cl, n-PrO, CF.sub.3), (M-6125, F, CH.sub.3, Cl, n-PrO,
Br), (M-6126, F, CH.sub.3, Cl, n-PrO, CH.sub.3), (M-6127, F,
CH.sub.3, Cl, PhO, H), (M-6128, F, CH.sub.3, Cl, PhO, Cl), (M-6129,
F, CH.sub.3, Cl, PhO, F), (M-6130, F, CH.sub.3, Cl, PhO, CF.sub.3),
(M-6131, F, CH.sub.3, Cl, PhO, Br), (M-6132, F, CH.sub.3, Cl, PhO,
CH.sub.3), (M-6133, F, CH.sub.3, Cl, BnO, H), (M-6134, F, CH.sub.3,
Cl, BnO, Cl), (M-6135, F, CH.sub.3, Cl, BnO, F), (M-6136, F,
CH.sub.3, Cl, BnO, CF.sub.3), (M-6137, F, CH.sub.3, Cl, BnO, Br),
(M-6138, F, CH.sub.3, Cl, BnO, CH.sub.3), (M-6139, F, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, H), (M-6140, F, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, Cl), (M-6141, F, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, F), (M-6142, F, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-6143, F, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, Br), (M-6144, F, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-6145, F, CH.sub.3, Cl,
CF.sub.3O, H), (M-6146, F, CH.sub.3, Cl, CF.sub.3O, Cl), (M-6147,
F, CH.sub.3, Cl, CF.sub.3O, F), (M-6148, F, CH.sub.3, Cl,
CF.sub.3O, CF.sub.3), (M-6149, F, CH.sub.3, Cl, CF.sub.3O, Br),
(M-6150, F, CH.sub.3, Cl, CF.sub.3O, CH.sub.3), (M-6151, F,
CH.sub.3, Cl, Ph, H), (M-6152, F, CH.sub.3, Cl, Ph, Cl), (M-6153,
F, CH.sub.3, Cl, Ph, F), (M-6154, F, CH.sub.3, Cl, Ph, CF.sub.3),
(M-6155, F, CH.sub.3, Cl, Ph, Br), (M-6156, F, CH.sub.3, Cl, Ph,
CH.sub.3), (M-6157, F, CH.sub.3, Cl, 4-F-Ph, H), (M-6158, F,
CH.sub.3, Cl, 4-F-Ph, Cl), (M-6159, F, CH.sub.3, Cl, 4-F-Ph, F),
(M-6160, F, CH.sub.3, Cl, 4-F-Ph, CF.sub.3), (M-6161, F, CH.sub.3,
Cl, 4-F-Ph, Br), (M-6162, F, CH.sub.3, Cl, 4-F-Ph, CH.sub.3),
(M-6163, F, CH.sub.3, Cl, 4-CF.sub.3-Ph, H), (M-6164, F, CH.sub.3,
Cl, 4-CF.sub.3-Ph, Cl), (M-6165, F, CH.sub.3, Cl, 4-CF.sub.3-Ph,
F), (M-6166, F, CH.sub.3, Cl, 4-CF.sub.3-Ph, CF.sub.3), (M-6167, F,
CH.sub.3, Cl, 4-CF.sub.3-Ph, Br), (M-6168, F, CH.sub.3, Cl,
4-CF.sub.3-Ph, CH.sub.3), (M-6169, F, CH.sub.3, Cl,
4-(Me).sub.2N-Ph, H), (M-6170, F, CH.sub.3, Cl, 4-(Me).sub.2N-Ph,
Cl), (M-6171, F, CH.sub.3, Cl, 4-(Me).sub.2N-Ph, F), (M-6172, F,
CH.sub.3, Cl, 4-(Me).sub.2N-Ph, CF.sub.3), (M-6173, F, CH.sub.3,
Cl, 4-(Me).sub.2N-Ph, Br), (M-6174, F, CH.sub.3, Cl,
4-(Me).sub.2N-Ph, CH.sub.3), (M-6175, F, CH.sub.3, Cl, 4-OH-Ph, H),
(M-6176, F, CH.sub.3, Cl, 4-OH-Ph, Cl), (M-6177, F, CH.sub.3, Cl,
4-OH-Ph, F), (M-6178, F, CH.sub.3, Cl, 4-OH-Ph, CF.sub.3), (M-6179,
F, CH.sub.3, Cl, 4-OH-Ph, Br), (M-6180, F, CH.sub.3, Cl, 4-OH-Ph,
CH.sub.3), (M-6181, F, CH.sub.3, Cl, 3,4-di-F-Ph, H), (M-6182, F,
CH.sub.3, Cl, 3,4-di-F-Ph, Cl), (M-6183, F, CH.sub.3, Cl,
3,4-di-F-Ph, F), (M-6184, F, CH.sub.3, Cl, 3,4-di-F-Ph, CF.sub.3),
(M-6185, F, CH.sub.3, Cl, 3,4-di-F-Ph, Br), (M-6186, F, CH.sub.3,
Cl, 3,4-di-F-Ph, CH.sub.3), (M-6187, F, CH.sub.3, Cl, 4-COOH-Ph,
H), (M-6188, F, CH.sub.3, Cl, 4-COOH-Ph, Cl), (M-6189, F, CH.sub.3,
Cl, 4-COOH-Ph, F), (M-6190, F, CH.sub.3, Cl, 4-COOH-Ph, CF.sub.3),
(M-6191, F, CH.sub.3, Cl, 4-COOH-Ph, Br), (M-6192, F, CH.sub.3, Cl,
4-COOH-Ph, CH.sub.3), (M-6193, F, CH.sub.3, Cl, Bn, H), (M-6194, F,
CH.sub.3, Cl, Bn, Cl), (M-6195, F, CH.sub.3, Cl, Bn, F), (M-6196,
F, CH.sub.3, Cl, Bn, CF.sub.3), (M-6197, F, CH.sub.3, Cl, Bn, Br),
(M-6198, F, CH.sub.3, Cl, Bn, CH.sub.3), (M-6199, F, CH.sub.3, Cl,
4-F-Bn, H), (M-6200, F, CH.sub.3, Cl, 4-F-Bn, Cl), (M-6201, F,
CH.sub.3, Cl, 4-F-Bn, F), (M-6202, F, CH.sub.3, Cl, 4-F-Bn,
CH.sub.3), (M-6203, F, CH.sub.3, Cl, 4-F-Bn, Br), (M-6204, F,
CH.sub.3, Cl, 4-F-Bn, CH.sub.3), (M-6205, F, CH.sub.3, Cl, 2-Py,
H), (M-6206, F, CH.sub.3, Cl, 2-Py, Cl), (M-6207, F, CH.sub.3, Cl,
2-Py, F), (M-6208, F, CH.sub.3, Cl, 2-Py, CF.sub.3), (M-6209, F,
CH.sub.3, Cl, 2-Py, Br), (M-6210, F, CH.sub.3, Cl, 2-Py, CH.sub.3),
(M-6211, F, CH.sub.3, Cl, 3-Py, H), (M-6212, F, CH.sub.3, Cl, 3-Py,
Cl), (M-6213, F, CH.sub.3, Cl, 3-Py, F), (M-6214, F, CH.sub.3, Cl,
3-Py, CF.sub.3), (M-6215, F, CH.sub.3, Cl, 3-Py, Br), (M-6216, F,
CH.sub.3, Cl, 3-Py, CH.sub.3), (M-6217, F, CH.sub.3, Cl, 4-Py, H),
(M-6218, F, CH.sub.3, Cl, 4-Py, Cl), (M-6219, F, CH.sub.3, Cl,
4-Py, F), (M-6220, F, CH.sub.3, Cl, 4-Py, CF.sub.3), (M-6221, F,
CH.sub.3, Cl, 4-Py, Br), (M-6222, F, CH.sub.3, Cl, 4-Py, CH.sub.3),
(M-6223, F, CH.sub.3, Cl, 2-Th, H), (M-6224, F, CH.sub.3, Cl, 2-Th,
Cl), (M-6225, F, CH.sub.3, Cl, 2-Th, F), (M-6226, F, CH.sub.3, Cl,
2-Th, CF.sub.3), (M-6227, F, CH.sub.3, Cl, 2-Th, Br), (M-6228, F,
CH.sub.3, Cl, 2-Th, CH.sub.3), (M-6229, F, CH.sub.3, Cl, 3-Th, H),
(M-6230, F, CH.sub.3, Cl, 3-Th, Cl), (M-6231, F, CH.sub.3, Cl,
3-Th, F), (M-6232, F, CH.sub.3, Cl, 3-Th, CF.sub.3), (M-6233, F,
CH.sub.3, Cl, 3-Th, Br), (M-6234, F, CH.sub.3, Cl, 3-Th, CH.sub.3),
(M-6235, F, CH.sub.3, Cl, pyrrazol-2-yl, H), (M-6236, F, CH.sub.3,
Cl, pyrrazol-2-yl, Cl), (M-6237, F, CH.sub.3, Cl, pyrrazol-2-yl,
F), (M-6238, F, CH.sub.3, Cl, pyrrazol-2-yl, CF.sub.3), (M-6239, F,
CH.sub.3, Cl, pyrrazol-2-yl, Br), (M-6240, F, CH.sub.3, Cl,
pyrrazol-2-yl, CH.sub.3), (M-6241, F, CH.sub.3, Cl, pyrrazol-3-yl,
H), (M-6242, F, CH.sub.3, Cl, pyrrazol-3-yl, Cl), (M-6243, F,
CH.sub.3, Cl, pyrrazol-3-yl, F), (M-6244, F, CH.sub.3, Cl,
pyrrazol-3-yl, CF.sub.3), (M-6245, F, CH.sub.3, Cl, pyrrazol-3-yl,
Br), (M-6246, F, CH.sub.3, Cl, pyrrazol-3-yl, CH.sub.3), (M-6247,
F, CH.sub.3, Cl, pyrimidin-2-yl, H), (M-6248, F, CH.sub.3, Cl,
pyrimidin-2-yl, Cl), (M-6249, F, CH.sub.3, Cl, pyrimidin-2-yl, F),
(M-6250, F, CH.sub.3, Cl, pyrimidin-2-yl, CF.sub.3), (M-6251, F,
CH.sub.3, Cl, pyrimidin-2-yl, Br), (M-6252, F, CH.sub.3, Cl,
pyrimidin-2-yl, CH.sub.3), (M-6253, F, CH.sub.3, Cl,
pyrimidin-4-yl, H), (M-6254, F, CH.sub.3, Cl, pyrimidin-4-yl, Cl),
(M-6255, F, CH.sub.3, Cl, pyrimidin-4-yl, F), (M-6256, F, CH.sub.3,
Cl, pyrimidin-4-yl, CF.sub.3), (M-6257, F, CH.sub.3, Cl,
pyrimidin-4-yl, Br), (M-6258, F, CH.sub.3, Cl, pyrimidin-4-yl,
CH.sub.3), (M-6259, F, CH.sub.3, Cl, pyrimidin-5-yl, H), (M-6260,
F, CH.sub.3, Cl, pyrimidin-5-yl, Cl), (M-6261, F, CH.sub.3, Cl,
pyrimidin-5-yl, F), (M-6262, F, CH.sub.3, Cl, pyrimidin-5-yl,
CF.sub.3), (M-6263, F, CH.sub.3, Cl, pyrimidin-5-yl, Br), (M-6264,
F, CH.sub.3, Cl, pyrimidin-5-yl, CH.sub.3), (M-6265, F, CH.sub.3,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-6266, F, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-6267, F, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-6268, F, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-6269, F, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2Br), (M-6270, F, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-6271, F, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-6272, F, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-6273, F, CH.sub.3,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6274, F, CH.sub.3,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-6275, F,
CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-6276,
F, CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-6277, F, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-6278, F,
CH.sub.3, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-6279, F, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6280, F,
CH.sub.3, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-6281, F, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-6282, F,
CH.sub.3, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-6283, F, CH
.sub.3, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
H), (M-6284, F, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-6285, F, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6286,
F, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-6287, F, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-6288, F, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-6289, F, CH.sub.3, Cl, MeOCH.sub.2, H), (M-6290, F, CH.sub.3,
Cl, MeOCH.sub.2, Cl), (M-6291, F, CH.sub.3, Cl, MeOCH.sub.2, F),
(M-6292, F, CH.sub.3, Cl, MeOCH.sub.2, CF.sub.3), (M-6293, F,
CH.sub.3, Cl, MeOCH.sub.2, Br), (M-6294, F, CH.sub.3, Cl,
MeOCH.sub.2, CH.sub.3), (M-6295, F, CH.sub.3, Cl, EtOCH.sub.2, H),
(M-6296, F, CH.sub.3, Cl, EtOCH.sub.2, Cl), (M-6297, F, CH.sub.3,
Cl, EtOCH.sub.2, F), (M-6298, F, CH.sub.3, Cl, EtOCH.sub.2,
CF.sub.3), (M-6299, F, CH.sub.3, Cl, EtOCH.sub.2, Br), (M-6300, F,
CH.sub.3, Cl, EtOCH.sub.2, CH.sub.3), (M-6301, F, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, H), (M-6302, F, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, Cl), (M-6303, F, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, F), (M-6304, F, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-6305, F, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, Br), (M-6306, F, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-6307, F, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-6308, F, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-6309, F, CH.sub.3,
Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-6310, F, CH.sub.3,
Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-6311, F,
CH.sub.3, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-6312,
F, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-6313, F, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2, H), (M-6314, F,
CH.sub.3, Cl, MeOCH.sub.2CH.sub.2, Cl), (M-6315, F, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, F), (M-6316, F, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-6317, F, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, Br), (M-6318, F, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-6319, F, CH.sub.3, Cl,
HOCH.sub.2, H), (M-6320, F, CH.sub.3, Cl, HOCH.sub.2, Cl), (M-6321,
F, CH.sub.3, Cl, HOCH.sub.2, F), (M-6322, F, CH.sub.3, Cl,
HOCH.sub.2, CF.sub.3), (M-6323, F, CH.sub.3, Cl, HOCH.sub.2, Br),
(M-6324, F, CH.sub.3, Cl, HOCH.sub.2, CH.sub.3), (M-6325, F,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2, H), (M-6326, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, Cl), (M-6327, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, F), (M-6328, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-6329, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, Br), (M-6330, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-6331, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-6332, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-6333, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-6334, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-6335, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-6336, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-6337, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-6338, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-6339, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6340, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-6341, F,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-6342, F,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-6343, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-6344, F,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl),
(M-6345, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3, F), (M-6346, F,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-6347, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-6348, F,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2 CH.sub.2,
CH.sub.3), (M-6349, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-6350, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-6351, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-6352, F, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-6353, F,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-6354, F,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-6355, F, CH.sub.3, Cl, (Me).sub.2N, H), (M-6356, F, CH.sub.3,
Cl, (Me).sub.2N, Cl), (M-6357, F, CH.sub.3, Cl, (Me).sub.2N, F),
(M-6358, F, CH.sub.3, Cl, (Me).sub.2N, CF.sub.3), (M-6359, F,
CH.sub.3, Cl, (Me).sub.2N, Br), (M-6360, F, CH.sub.3, Cl,
(Me).sub.2H, CH.sub.3), (M-6361, F, CH.sub.3, Cl,
piperidin-4-yl-methyl, H), (M-6362, F, CH.sub.3, Cl,
piperidin-4-yl-methyl, Cl), (M-6363, F, CH.sub.3, Cl,
piperidin-4-yl-methyl, F), (M-6364, F, CH.sub.3, Cl,
piperidin-4-yl-methyl, CF.sub.3), (M-6365, F, CH.sub.3, Cl,
piperidin-4-yl-methyl, Br), (M-6366, F, CH.sub.3, Cl,
piperidin-4-yl-methyl, CH.sub.3), (M-6367, F, CH.sub.3, Cl,
cyclohexylmethyl, H), (M-6368, F, CH.sub.3, Cl, cyclohexylmethyl,
Cl), (M-6369, F, CH.sub.3, Cl, cyclohexylmethyl, F), (M-6370, F,
CH.sub.3, Cl, cyclohexylmethyl, CF.sub.3), (M-6371, F, CH.sub.3,
Cl, cyclohexylmethyl, Br), (M-6372, F, CH.sub.3, Cl,
cyclohexylmethyl, CH.sub.3), (M-6373, Cl, H, H, H, H), (M-6374, Cl,
H, H, H, Cl), (M-6375, MeO, F, H, H, F), (M-6376, MeO, F, H, H,
c-Pr), (M-6377, Cl, H, H, H, Br), (M-6378, Cl, H, H, H, CH.sub.3),
(M-6379, MeO, H, H, F, c-Pr), (M-6380, Cl, H, H, F, Cl), (M-6381,
MeO, H, H, F, F), (M-6382, Cl, H, H, F, CF.sub.3), (M-6383, Cl, H,
H, F, Br), (M-6384, Cl, H, H, F, CH.sub.3), (M-6385, Cl, H, H, Cl,
H), (M-6386, MeO, F, H, H, Et), (M-6387, MeO, H, H, Cl, F),
(M-6388, Cl, H, H, Cl, CF.sub.3), (M-6389, Cl, H, H, Cl, Br),
(M-6390, Cl, H, H, Cl, CH.sub.3), (M-6391, Cl, H, H, CH.sub.3, H),
(M-6392, Cl, H, H, CH.sub.3, Cl), (M-6393, Cl, H, H, CH.sub.3, F),
(M-6394, Cl, H, H, CH.sub.3, CF.sub.3), (M-6395, Cl, H, H,
CH.sub.3, Br), (M-6396, Cl, H, H, CH.sub.3, CH.sub.3), (M-6397, Cl,
H, H, Et, H), (M-6398, Cl, H, H, Et, Cl), (M-6399, Cl, H, H, Et,
F), (M-6400, Cl, H, H, Et, CF.sub.3), (M-6401, Cl, H, H, Et, Br),
(M-6402, Cl, H, H, Et, CH.sub.3), (M-6403, Cl, H, H, n-Pr, H),
(M-6404, Cl, H, H, n-Pr, Cl), (M-6405, Cl, H, H, n-Pr, F), (M-6406,
Cl, H, H, n-Pr, CF.sub.3), (M-6407, Cl, H, H, n-Pr, Br), (M-6408,
Cl, H, H, n-Pr, CH.sub.3), (M-6409, Cl, H, H, c-Pr, H), (M-6410,
Cl, H, H, c-Pr, Cl), (M-6411, Cl, H, H, c-Pr, F), (M-6412, Cl, H,
H, c-Pr, CF.sub.3), (M-6413, Cl, H, H, c-Pr, Br), (M-6414, Cl, H,
H, c-Pr, CH.sub.3), (M-6415, Cl, H, H, i-Pr, H), (M-6416, Cl, H, H,
i-Pr, Cl), (M-6417, Cl, H, H, i-Pr, F), (M-6418, Cl, H, H, i-Pr,
CF.sub.3), (M-6419, Cl, H, H, i-Pr, Br), (M-6420, Cl, H, H, i-Pr,
CH.sub.3), (M-6421, MeO, H, H, n-Bu, H), (M-6422, Cl, H, H, n-Bu,
Cl), (M-6423, Cl, H, H, n-Bu, F), (M-6424, Cl, H, H, n-Bu,
CF.sub.3), (M-6425, Cl, H, H, n-Bu, Br), (M-6426, Cl, H, H, n-Bu,
CH.sub.3), (M-6427, Cl, H, H, i-Bu, H), (M-6428, Cl, H, H, i-Bu,
Cl), (M-6429, CL, H, H, i-Bu, F), (M-6430, Cl, H, H, i-Bu,
CF.sub.3), (M-6431, Cl, H, H, i-Bu, Br), (M-6432, Cl, H, H, i-Bu,
CH.sub.3), (M-6433, Cl, H, H, sec-Bu, H), (M-6434, Cl, H, H,
sec-Bu, Cl), (M-6435, Cl, H, H, sec-Bu, F), (M-6436, Cl, H, H,
sec-Bu, CF.sub.3), (M-6437, Cl, H, H, sec-Bu, Br), (M-6438, Cl, H,
H, sec-Bu, CH.sub.3), (M-6439, Cl, H, H, n-Pen, H), (M-6440, Cl, H,
H, n-Pen, Cl), (M-6441, MeO, H, H, n-Pen, F), (M-6442, Cl, H, H,
n-Pen, CF.sub.3), (M-6443, Cl, H, H, n-Pen, Br), (M-6444, Cl, H, H,
n-Pen, CH.sub.3), (M-6445, Cl, H, H, c-Pen, H), (M-6446, Cl, H, H,
c-Pen, Cl), (M-6447, Cl, H, H, c-Pen, F), (M-6448, Cl, H, H, c-Pen,
CF.sub.3), (M-6449, Cl, H, H, c-Pen, Br), (M-6450, Cl, H, H, c-Pen,
CH.sub.3), (M-6451, Cl, H, H, n-Hex, H), (M-6452, Cl, H, H, n-Hex,
Cl), (M-6453, Cl, H, H, n-Hex, F), (M-6454, Cl, H, H, n-Hex,
CF.sub.3), (M-6455, Cl, H, H, n-Hex, Br), (M-6456, Cl, H, H, n-Hex,
CH.sub.3), (M-6457, Cl, H, H, c-Hex, H), (M-6458, Cl, H, H, c-Hex,
Cl), (M-6459, Cl, H, H, c-Hex, F), (M-6460, Cl, H, H, c-Hex,
CF.sub.3), (M-6461, Cl, H, H, c-Hex, Br), (M-6462, Cl, H, H, c-Hex,
CH.sub.3), (M-6463, Cl, H, H, OH, H), (M-6464, Cl, H, H, OH, Cl),
(M-6465, Cl, H, H, OH, F), (M-6460, Cl, H, H, OH, CF.sub.3),
(M-6467, Cl, H, H, OH, Br), (M-6468, Cl, H, H, OH, CH.sub.3),
(M-6469, Cl, H, H, EtO, H), (M-6470, Cl, H, H, EtO, Cl), (M-6471,
Cl, H, H, EtO, F), (M-6472, Cl, H, H, EtO, CF.sub.3), (M-6473, Cl,
H, H, EtO, Br), (M-6474, Cl, H, H, EtO, CH.sub.3), (M-6475, Cl, H,
H, n-PrO, H), (M-6476, Cl, H, H, n-PrO, Cl), (M-6477, Cl, H, H,
n-PrO, F), (M-6478, Cl, H, H, n-PrO, CF.sub.3), (M-6479, Cl, H, H,
n-PrO, Br), (M-6480, Cl, H, H, n-PrO, CH.sub.3), (M-6481, Cl, H, H,
PhO, H), (M-6482, Cl, H, H, PhO, Cl), (M-6483, Cl, H, H, PhO, F),
(M-6484, Cl, H, H, PhO, CF.sub.3), (M-6485, Cl, H, H, PhO, Br),
(M-6486, Cl, H, H, PhO, CH.sub.3), (M-6487, Cl, H, H, BnO, H),
(M-6488, Cl, H, H, BnO, Cl), (M-6489, Cl, H, H, BnO, F), (M-6490,
Cl, H, H, BnO, CF.sub.3), (M-6491, Cl, H, H, BnO, Br), (M-6492, Cl,
H, H, BnO, CH.sub.3), (M-6493, Cl, H, H, PhCH.sub.2CH.sub.2O, H),
(M-6494, Cl, H, H, PhCH.sub.2CH.sub.2O, Cl), (M-6495, Cl, H, H,
PhCH.sub.2CH.sub.2O, F), (M-6496, Cl, H, H, PhCH.sub.2CH.sub.2O,
CF.sub.3), (M-6497, Cl, H, H, PhCH.sub.2CH.sub.2O, Br), (M-6498,
Cl, H, H, PhCH.sub.2CH.sub.2O, CH.sub.3), (M-6499, MeO, H, H,
CF.sub.3O, CF.sub.3), (M-6500, Cl, H, H, CF.sub.3O, Cl), (M-6501,
Cl, H, H, CF.sub.3O, F), (M-6502, Cl, H, H, CF.sub.3O, CF.sub.3),
(M-6503, Cl, H, H, CF.sub.3O, Br), (M-6504, Cl, H, H, CF.sub.3O,
CH.sub.3), (M-6505, MeO, H, H, Ph, H), (M-6506, Cl, H, H, Ph, Cl),
(M-6507, Cl, H, H, Ph, F), (M-6508, Cl, H, H, Ph, CF.sub.3),
(M-6509, Cl, H, H, Ph, Br), (M-6510, Cl, H, H, Ph, CH.sub.3),
(M-6511, Cl, H, H, 4-F-Ph, H), (M-6512, Cl, H, H, 4-F-Ph, Cl),
(M-6513, Cl, H, H, 4-F-Ph, F), (M-6514, Cl, H, H, 4-F-Ph,
CF.sub.3), (M-6515, Cl, H, H, 4-F-Ph, Br), (M-6516, Cl, H, H,
4-F-Ph, CH.sub.3), (M-6517, Cl, H, H, 4-CF.sub.3-Ph, H), (M-6518,
Cl, H, H, 4-CF.sub.3-Ph, Cl), (M-6519, Cl, H, H, 4-CF.sub.3-Ph, F),
(M-6520, Cl, H, H, 4-CF.sub.3-Ph, CF.sub.3), (M-6521, Cl, H, H,
4-CF.sub.3-Ph, Br), (M-6522, Cl, H, H, 4-CF.sub.3-Ph, CH.sub.3),
(M-6523, Cl, H, H, 4-(Me).sub.2N-Ph, H), (M-6524, Cl, H, H,
4-(Me).sub.2N-Ph, Cl), (M-6525, Cl, H, H, 4-(Me).sub.2N-Ph, F),
(M-6526, Cl, H, H, 4-(Me).sub.2N-Ph, CF.sub.3), (M-6527, Cl, H, H,
4-(Me).sub.2N-Ph, Br), (M-6528, Cl, H, H, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-6529, Cl, H, H, 4-OH-Ph, H), (M-6530, Cl, H, H,
4-OH-Ph, Cl), (M-6531, Cl, H, H, 4-OH-Ph, F), (M-6532, Cl, H, H,
4-OH-Ph, CF.sub.3), (M-6533, Cl, H, H, 4-OH-Ph, Br), (M-6534, Cl,
H, H, 4-OH-Ph, CH.sub.3), (M-6535, Cl, H, H, 3,4-di-F-Ph, H),
(M-6536, Cl, H, H, 3,4-di-F-Ph, Cl), (M-6537, Cl, H, H,
3,4-di-F-Ph, F), (M-6538, Cl, H, H, 3,4-di-F-Ph, CF.sub.3),
(M-6539, Cl, H, H, 3,4-di-F-Ph, Br), (M-6540, Cl, H, H,
3,4-di-F-Ph, CH.sub.3), (M-6541, Cl, H, H, 4-COOH-Ph, H), (M-6542,
Cl, H, H, 4-COOH-Ph, Cl), (M-6543, Cl, H, H, 4-COOH-Ph, F),
(M-6544, Cl, H, H, 4-COOH-Ph, CF.sub.3), (M-6545, Cl, H, H,
4-COOH-Ph, Br), (M-6546, Cl, H, H, 4-COOH-Ph, CH.sub.3), (M-6547,
Cl, H, H, Bn, H), (M-6548, Cl, H, H, Bn, Cl), (M-6049, Cl, H, H,
Bn, F), (M-6550, Cl, H, H, Bn, CF.sub.3), (M-6551, Cl, H, H, Bn,
Br), (M-6552, Cl, H, H, Bn, CH.sub.3), (M-6553, Cl, H, H, 4-F-Bn,
H), (M-6554, Cl, H, H, 4-F-Bn, Cl), (M-6555, Cl, H, H, 4-F-Bn, F),
(M-6556, Cl, H, H, 4-F-Bn, CF.sub.3), (M-6557, Cl, H, H, 4-F-Bn,
Br), (M-6558, Cl, H, H, 4-F-Bn, CH.sub.3), (M-6559, Cl, H, H, 2-Py,
H), (M-6560, Cl, H, H, 2-Py, Cl), (M-6561, Cl, H, H, 2-Py, F),
(M-6562, Cl, H, H, 2-Py, CF.sub.3), (M-6563, Cl, H, H, 2-Py, Br),
(M-6564, Cl, H, H, 2-Py, CH.sub.3), (M-6565, Cl, H, H, 3-Py, H),
(M-6566, Cl, H, H, 3-Py, Cl), (M-6667, Cl, H, H, 3-Py, F), (M-6568,
Cl, H, H, 3-Py, CF.sub.3), (M-6569, Cl, H, H, 3-Py, Br), (M-6570,
Cl, H, H, 3-Py, CH.sub.3), (M-6571, Cl, H, H, 4-Py, H), (M-6572,
Cl, H, H, 4-Py, Cl), (M-6573, Cl, H, H, 4-Py, F), (M-6574, Cl, H,
H, 4-Py, CF.sub.3), (M-6575, Cl, H, H, 4-Py, Br), (M-6576, Cl, H,
H, 4-Py, CH.sub.3), (M-6577, Cl, H, H, 2-Th, H), (M-6578, Cl, H, H,
2-Th, Cl), (M-6579, Cl, H, H, 2-Th, F), (M-6680, Cl, H, H, 2-Th,
CF.sub.3), (M-6581, Cl, H, H, 2-Th, Br), (M-6582, Cl, H, H, 2-Th,
CH.sub.3), (M-6583, Cl, H, H, 3-Th, H), (M-6584, Cl, H, H, 3-Th,
Cl), (M-6585, Cl, H, H, 3-Th, F), (M-6586, Cl, H, H, 3-Th,
CF.sub.3), (M-6587, Cl, H, H, 3-Th, Br), (M-6588, Cl, H, H, 3-Th,
CH.sub.3), (M-6589, Cl, H, H, pyrrazol-2-yl, H), (M-6590, Cl, H, H,
pyrrazol-2-yl, Cl), (M-6591, Cl, H, H, pyrrazol-2-yl, F), (M-6592,
Cl, H, H, pyrrazol-2-yl, CF.sub.3), (M-6593, Cl, H, H,
pyrrazol-2-yl, Br), (M-6594, Cl, H, H, pyrrazol-2-yl, CH.sub.3),
(M-6595, Cl, H, H, pyrrazol-3-yl, H), (M-6596, Cl, H, H,
pyrrazol-3-yl, Cl), (M-6597, Cl, H, H, pyrrazol-3-yl, F), (M-6598,
Cl, H, H, pyrrazol-3-yl, CF.sub.3), (M-6599, Cl, H, H,
pyrrazol-3-yl, Br), (M-6600, Cl, H, H, pyrrazol-3-yl, CH.sub.3),
(M-6601, Cl, H, H, pyrimidin-2-yl, H), (M-6602, Cl, H, H,
pyrimidin-2-yl, Cl), (M-6603, Cl, H, H, pyrimidin-2-yl, F),
(M-6604, Cl, H, H, pyrimidin-2-yl, CF.sub.3), (M-6605, Cl, H, H,
pyrimidin-2-yl, Br), (M-6606, Cl, H, H, pyrimidin-2-yl, CH.sub.3),
(M-6607, Cl, H, H, pyrimidin-4-yl, H), (M-6608, Cl, H, H,
pyrimidin-4-yl, Cl), (M-6609, Cl, H, H, pyrimidin-4-yl, F),
(M-6610, Cl, H, H, pyrimidin-4-yl, CF.sub.3), (M-6611, Cl, H, H,
pyrimidin-4-yl, Br), (M-6612, Cl, H, H, pyrimidin-4-yl, CH.sub.3),
(M-6613, Cl, H, H, pyrimidin-5-yl, H), (M-6614, Cl, H, H,
pyrimidin-5-yl, Cl), (M-6615, Cl, H, H, pyrimidin-5-yl, F),
(M-6616, Cl, H, H, pyrimidin-5-yl, CF.sub.3), (M-6617, Cl, H, H,
pyrimidin-5-yl, Br), (M-6618, Cl, H, H, pyrimidin-5-yl, CH.sub.3),
(M-6619, Cl, H, H, HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-6620, Cl,
H, H, HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-6621, Cl, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-6622, Cl, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-6623, Cl, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-6624, Cl, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-6625, Cl, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-6626, Cl, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-6627, Cl, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6628, Cl, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-6629, Cl, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-6630, Cl, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-6631, Cl, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-6632, Cl, H,
H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-6633, Cl,
H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6634,
Cl, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-6635, Cl, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-6636, Cl, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.2), (M-6637,
Cl, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
H), (M-6638, Cl, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-6639,
Cl, H, H, (Me)
.sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6640, Cl,
H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-6641, Cl, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-6642, Cl, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-6643, Cl, H, H, MeOCH.sub.2, H), (M-6644, Cl, H, H, MeOCH.sub.2,
Cl), (M-6645, Cl, H, H, MeOCH.sub.2, F), (M-6646, Cl, H, H,
MeOCH.sub.2, CF.sub.3), (M-6647, Cl, H, H, MeOCH.sub.2, Br),
(M-6648, Cl, H, H, MeOCH.sub.2, CH.sub.3), (M-6649, Cl, H, H,
EtOCH.sub.2, H), (M-6650, Cl, H, H, EtOCH.sub.2, Cl), (M-6651, Cl,
H, H, EtOCH.sub.2, F), (M-6652, Cl, H, H, EtOCH.sub.2, CF.sub.3),
(M-6653, Cl, H, H, EtOCH.sub.2, Br), (M-6654, Cl, H, H,
EtOCH.sub.2, CH.sub.3), (M-6655, Cl, H, H, EtOCH.sub.2CH.sub.2, H),
(M-6656, Cl, H, H, EtOCH.sub.2CH.sub.2, Cl), (M-6657, Cl, H, H,
EtOCH.sub.2CH.sub.2, F), (M-6658, Cl, H, H, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-6659, Cl, H, H, EtOCH.sub.2CH.sub.2, Br), (M-6660,
Cl, H, H, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-6661, Cl, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-6662, Cl, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-6663, Cl, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-6664, Cl, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-6665, Cl, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-6666, Cl, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-6667, Cl, H, H,
MeOCH.sub.2CH.sub.2, H), (M-6668, Cl, H, H, MeOCH.sub.2CH.sub.2,
Cl), (M-6669, Cl, H, H, MeOCH.sub.2CH.sub.2, F), (M-6670, Cl, H, H,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-6671, Cl, H, H,
MeOCH.sub.2CH.sub.2, Br), (M-6672, Cl, H, H, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-6673, Cl, H, H, HOCH.sub.2, H), (M-6674, Cl, H, H,
HOCH.sub.2, Cl), (M-6675, Cl, H, H, HOCH.sub.2, F), (M-6676, Cl, H,
H, HOCH.sub.2, CF.sub.3), (M-6677, Cl, H, H, HOCH.sub.2, Br),
(M-6678, Cl, H, H, HOCH.sub.2, CH.sub.3), (M-6679, Cl, H, H,
HOCH.sub.2CH.sub.2, H), (M-6680, Cl, H, H, HOCH.sub.2CH.sub.2, Cl),
(M-6681, Cl, H, H, HOCH.sub.2CH.sub.2, F), (M-6682, Cl, H, H,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-6683, Cl, H, H,
HOCH.sub.2CH.sub.2, Br), (M-6684, Cl, H, H, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-6685, Cl, H, H, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-6686, Cl, H, H, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-6687, Cl, H,
H, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-6688, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-6689, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-6690, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-6691, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-6692, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-6693, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6694, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), <M-6695, Cl, H,
H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-6696, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-6697, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-6698, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-6699, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6700, Cl, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-6701, Cl,
H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-6702, Cl,
H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-6703, Cl, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H),
(M-6704, Cl, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-6705, Cl, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.3, F),
(M-6706, Cl, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-6707, Cl, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-6708, Cl, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-6709, Cl, H, H, (Me).sub.2N, H), (M-6710, Cl, H, H, (Me).sub.2N,
Cl), (M-6711, Cl, H, H, (Me).sub.2N, F), (M-6712, Cl, H, H,
(Me).sub.2N, CF.sub.3), (M-6713, Cl, H, H, (Me).sub.2N, Br),
(M-6714, Cl, H, H, (Me).sub.2N, CH.sub.3), (M-6715, Cl, H, H,
piperidin-4-yl-methyl, H), (M-6716, Cl, H, H,
piperidin-4-yl-methyl, Cl), (M-6717, Cl, H, H,
piperidin-4-yl-methyl, F), (M-6718, Cl, H, H,
piperidin-4-yl-methyl, CF.sub.3), (M-6719, Cl, H, H,
piperidin-4-yl-methyl, Br), (M-6720, Cl, H, H,
piperidin-4-yl-methyl, CH.sub.3), (M-6721, Cl, H, H,
cyclohexylmethyl, H), (M-6722, Cl, H, H, cyclohexylmethyl, Cl),
(M-6723, Cl, H, H, cyclohexylmethyl, F), (M-6724, Cl, H, H,
cyclohexylmethyl, CF.sub.3), (M-6725, Cl, H, H, cyclohexylmethyl,
Br), (M-6726, Cl, H, H, cyclohexylmethyl, CH.sub.3), (M-6727, MeO,
H, F, H, H), (M-6728, Cl, H, F, H, Cl), (M-6729, MeO, H, F, H, F),
(M-6730, MeO, H, F, H, CF.sub.3), (M-6731, MeO, H, F, H, Br),
(M-6732, MeO, H, F, H, CH.sub.3), (M-6733, MeO, H, F, F, H),
(M-6734, Cl, H, F, F, Cl), (M-6735, Cl, H, F, F, F), (M-6736, Cl,
H, F, F, CF.sub.3), (M-6737, Cl, H, F, F, Br), (M-6738, Cl, H, F,
F, CH.sub.3), (M-6739, Cl, H, F, Cl, H), (M-6740, Cl, H, F, Cl,
Cl), (M-6741, Cl, H, F, Cl, F), (M-6742, Cl, H, F, Cl, CF.sub.3),
(M-6743, Cl, H, F, Cl, Br), (M-6744, Cl, H, F, Cl, CH.sub.3),
(M-6745, MeO, H, F, CH.sub.3, H), (M-6746, Cl, H, F, CH.sub.3, Cl),
(M-6747, Cl, H, F, CH.sub.3, F), (M-6748, Cl, H, F, CH.sub.3,
CF.sub.3), (M-6749, Cl, H, F, CH.sub.3, Br), (M-6750, Cl, H, F,
CH.sub.3, CH.sub.3), (M-6751, MeO, H, F, Et, H), (M-6752, Cl, H, F,
Et, Cl), (M-6753, Cl, H, F, Et, F), (M-6754, Cl, H, F, Et,
CF.sub.3), (M-6755, Cl, H, F, Et, Br), (M-6756, Cl, H, F, Et,
CH.sub.3), (M-6757, MeO, H, F, n-Pr, H), (M-6758, Cl, H, F, n-Pr,
Cl), (M-6759, Cl, H, F, n-Pr, F), (M-6760, Cl, H, F, n-Pr,
CF.sub.3), (M-6761, MeO, H, F, n-Pr, Br), (M-6762, Cl, H, F, n-Pr,
CH.sub.3), (M-6763, Cl, H, F, c-Pr, H), (M-6764, Cl, H, F, c-Pr,
Cl), (M-6765, Cl, H, F, c-Pr, F), (M-6766, Cl, H, F, c-Pr,
CF.sub.3), (M-6767, Cl, H, F, c-Pr, Br), (M-6768, Cl, H, F, c-Pr,
CH.sub.3), (M-6769, Cl, H, F, i-Pr, H), (M-6770, Cl, H, F, i-Pr,
Cl), (M-6771, Cl, H, F, i-Pr, F), (M-6772, Cl, H, F, i-Pr,
CF.sub.3), (M-6773, Cl, H, F, i-Pr, Br), (M-6774, Cl, H, F, i-Pr,
CH.sub.3), (M-6775, MeO, H, F, n-Bu, H), (M-6776, Cl, H, F, n-Bu,
Cl), (M-6777, Cl, H, F, n-Bu, F), (M-6778, Cl, H, F, n-Bu,
CF.sub.3), (M-6779, Cl, H, F, n-Bu, Br), (M-6780, Cl, H, F, n-Bu,
CH.sub.3), (M-6781, Cl, H, F, i-Bu, H), (M-6782, Cl, H, F, i-Bu,
Cl), (M-6783, Cl, H, F, i-Bu, F), (M-6784, Cl, H, F, i-Bu,
CF.sub.3), (M-6785, Cl, H, F, i-Bu, Br), (M-6786, Cl, H, F, i-Bu,
CH.sub.3), (M-6787, Cl, H, F, sec-Bu, H), (M-6788, Cl, H, F,
sec-Bu, Cl), (M-6789, Cl, H, F, sec-Bu, F), (M-6790, Cl, H, F,
sec-Bu, CF.sub.3), (M-6791, Cl, H, F, sec-Bu, Br), (M-6792, Cl, H,
F, sec-Bu, CH.sub.3), (M-6793, MeO, H, F, n-Pen, H), (M-6794, Cl,
H, F, n-Pen, Cl), (M-6795, MeO, H, F, n-Pen, F), (M-6796, Cl, H, F,
n-Pen, CF.sub.3), (M-6797, Cl, H, F, n-Pen, Br), (M-6798, Cl, H, F,
n-Pen, CH.sub.3), (M-6799, Cl, H, F, c-Pen, H), (M-6800, Cl, H, F,
c-Pen, Cl), (M-6801, Cl, H, F, c-Pen, F), (M-6802, Cl, H, F, c-Pen,
CF.sub.3), (M-6803, Cl, H, F, c-Pen, Br), (M-6804, Cl, H, F, c-Pen,
CH.sub.3), (M-6805, MeO, H, F, n-Hex, H), (M-6806, Cl, H, F, n-Hex,
Cl), (M-6807, Cl, H, F, n-Hex, F), (M-6808, Cl, H, F, n-Hex,
CF.sub.3), (M-6809, Cl, H, F, n-Hex, Br), (M-6810, Cl, H, F, n-Hex,
CH.sub.3), (M-6811, MeO, H, F, c-Hex, H), (M-6812, Cl, H, F, c-Hex,
Cl), (M-6813, Cl, H, F, c-Hex, F), (M-6814, Cl, H, F, c-Hex,
CF.sub.3), (M-6815, Cl, H, F, c-Hex, Br), (M-6816, Cl, H, F, c-Hex,
CH.sub.3), (M-6817, Cl, H, F, OH, H), (M-6818, Cl, H, F, OH, Cl),
(M-6819, Cl, H, F, OH, F), (M-6820, Cl, H, F, OH, CF.sub.3),
(M-6821, Cl, H, F, OH, Br), (M-6822, Cl, H, F, OH, CH.sub.3),
(M-6823, MeO, H, F, EtO, H), (M-6824, Cl, H, F, EtO, Cl), (M-6825,
Cl, H, F, EtO, F), (M-6826, Cl, H, F, EtO, CF.sub.3), (M-6827, Cl,
H, F, EtO, Br), (M-6828, Cl, H, F, EtO, CH.sub.3), (M-6829, Cl, H,
F, n-PrO, H), (M-6830, Cl, H, F, n-PrO, Cl), (M-6831, Cl, H, F,
n-PrO, F), (M-6832, Cl, H, F, n-PrO, CF.sub.3), (M-6833, Cl, H, F,
n-PrO, Br), (M-6834, Cl, H, F, n-PrO, CH.sub.3), (M-6835, Cl, H, F,
PhO, H), (M-6836, Cl, H, F, PhO, Cl), (M-6837, Cl, H, F, PhO, F),
(M-6838, Cl, H, F, PhO, CF.sub.3), (M-6839, Cl, H, F, PhO, Br),
(M-6840, Cl, H, F, PhO, CH.sub.3), (M-6841, Cl, H, F, BnO, H),
(M-6842, Cl, H, F, BnO, Cl), (M-6843, Cl, H, F, BnO, F), (M-6844,
Cl, H, F, BnO, CF.sub.3), (M-6845, Cl, H, F, BnO, Br), (M-6846, Cl,
H, F, BnO, CH.sub.3), (M-6847, Cl, H, F, PhCH.sub.2CH.sub.2O, H),
(M-6848, Cl, H, F, PhCH.sub.2CH.sub.2O, Cl), (M-6849, Cl, H, F,
PhCH.sub.2CH.sub.2O, F), (M-6850, Cl, H, F, PhCH.sub.2CH.sub.2O,
CF.sub.3), (M-6851, Cl, H, F, PhCH.sub.2CH.sub.2O, Br), (M-6852,
Cl, H, F, PhCH.sub.2CH.sub.2O, CH.sub.3), (M-6853, Cl, H, F,
CF.sub.3O, H), (M-6854, Cl, H, F, CF.sub.3O, Cl), (M-6855, Cl, H,
F, CF.sub.3O, F), (M-6856, Cl, H, F, CF.sub.3O, CF.sub.3), (M-6857,
Cl, H, F, CF.sub.3O, Br), (M-6558, Cl, H, F, CF.sub.3O, CH.sub.3),
(M-6859, MeO, H, F, Ph, H), (M-6860, Cl, H, F, Ph, Cl), (M-6861,
MeO, H, F, Ph, F), (M-6862, Cl, H, F, Ph, CF.sub.3), (M-6863, Cl,
H, F, Ph, Br), (M-6864, Cl, H, F, Ph, CH.sub.3), (M-6865, MeO, H,
F, 4-F-Ph, H), (M-6866, Cl, H, F, 4-F-Ph, Cl), (M-6867, Cl, H, F,
4-F-Ph, F), (M-6868, Cl, H, F, 4-F-Ph, CF.sub.3), (M-6869, Cl, H,
F, 4-F-Ph, Br), (M-6870, Cl, H, F, 4-F-Ph, CH.sub.3), (M-6871, Cl,
H, F, 4-CF.sub.3-Ph, H), (M-6872, Cl, H, F, 4-CF.sub.3-Ph, Cl),
(M-6873, Cl, H, F, 4-CF.sub.3-Ph, F), (M-6874, Cl, H, F,
4-CF.sub.3-Ph, CF.sub.3), (M-6875, Cl, H, F, 4-CF.sub.3-Ph, Br),
(M-6876, Cl, H, F, 4-CF.sub.3-Ph, CH.sub.3), (M-6877, Cl, H, F,
4-(Me).sub.2N-Ph, H), (M-6878, Cl, H, F, 4-(Me).sub.2N-Ph, Cl),
(M-6879, Cl, H, F, 4-(Me).sub.2N-Ph, F), (M-6880, Cl, H, F,
4-(Me).sub.2N-Ph, CF.sub.3), (M-6881, Cl, H, F, 4-(Me).sub.2N-Ph,
Br), (M-6882, Cl, H, F, 4-(Me).sub.2N-Ph, CH.sub.3), (M-6883, Cl,
H, F, 4-OH-Ph, H), (M-6884, Cl, H, F, 4-OH-Ph, Cl), (M-6885, Cl, H,
F, 4-OH-Ph, F), (M-6886, Cl, H, F, 4-OH-Ph, CF.sub.3), (M-6887, Cl,
H, F, 4-OH-Ph, Br), (M-6888, Cl, H, F, 4-OH-Ph, CH.sub.3), (M-6889,
Cl, H, F, 3,4-di-F-Ph, H), (M-6890, Cl, H, F, 3,4-di-F-Ph, Cl),
(M-6891, Cl, H, F, 3,4-di-F-Ph, F), (M-6892, Cl, H, F, 3,4-di-F-Ph,
CF.sub.3), (M-6893, Cl, H, F, 3,4-di-F-Ph, Br), (M-6894, Cl, H, F,
3,4-di-F-Ph, CH.sub.3), (M-6895, Cl, H, F, 4-COOH-Ph, H), (M-6896,
Cl, H, F, 4-COOH-Ph, Cl), (M-6897, Cl, H, F, 4-COOH-Ph, F),
(M-6898, Cl, H, F, 4-COOH-Ph, CF.sub.3), (M-6899, Cl, H, F,
4-COOH-Ph, Br), (M-6900, Cl, H, F, 4-COOH-Ph, CH.sub.3), (M-6901,
MeO, H, F, Bn, H), (M-6902, Cl, H, F, Bn, Cl), (M-6903, Cl, H, F,
Bn, F), (M-6904, Cl, H, F, Bn, CF.sub.3), (M-6905, Cl, H, F, Bn,
Br), (M-6906, Cl, H, F, Bn, CH.sub.3), (M-6907, Cl, H, F, 4-F-Bn,
H), (M-6908, Cl, H, F, 4-F-Bn, Cl), (M-6909, Cl, H, F, 4-F-Bn, F),
(M-6910, Cl, H, F, 4-F-Bn, CF.sub.3), (M-6911, Cl, H, F, 4-F-Bn,
Br), (M-6912, Cl, H, F, 4-F-Bn, CH.sub.3), (M-6913, Cl, H, F, 2-Py,
H), (M-6914, Cl, H, F, 2-Py, Cl), (M-6916, Cl, H, F, 2-Py, F),
(M-6916, Cl, H, F, 2-Py, CF.sub.3), (M-6917, Cl, H, F, 2-Py, Br),
(M-6918, Cl, H, F, 2-Py, CH.sub.3), (M-6919, MeO, H, F, 3-Py, H),
(M-6920, Cl, H, F, 3-Py, Cl), (M-6921, Cl, H, F, 3-Py, F), (M-6922,
Cl, H, F, 3-Py, CF.sub.3), (M-6923, Cl, H, F, 3-Py, Br), (M-6924,
Cl, H, F, 3-Py, CH.sub.3), (M-6925, Cl, H, F, 4-Py, H), (M-6926,
Cl, H, F, 4-Py, Cl), (M-6927, Cl, H, F, 4-Py, F), (M-6928, Cl, H,
F, 4-Py, CF.sub.3), (M-6929, Cl, H, F, 4-Py, Br), (M-6930, Cl, H,
F, 4-Py, CH.sub.3), (M-6931, Cl, H, F, 2-Th, H), (M-6932, Cl, H, F,
2-Th, Cl), (M-6933, Cl, H, F, 2-Th, F), (M-6934, Cl, H, F, 2-Th,
CF.sub.3), (M-6935, Cl, H, F, 2-Th, Br), (M-6936, Cl, H, F, 2-Th,
CH.sub.3), (M-6937, Cl, H, F, 3-Th, H), (M-6938, Cl, H, F, 3-Th,
Cl), (M-6939, Cl, H, F, 3-Th, F), (M-6940, Cl, H, F, 3-Th,
CF.sub.3), (M-6941, Cl, H, F, 3-Th, Br), (M-6942, Cl, H, F, 3-Th,
CH.sub.3), (M-6943, Cl, H, F, pyrrazol-2-yl, H), (M-6944, Cl, H, F,
pyrrazol-2-yl, Cl), (M-6945, Cl, H, F, pyrrazol-2-yl, F), (M-6946,
Cl, H, F, pyrrazol-2-yl, CF.sub.3), (M-6947, Cl, H, F,
pyrrazol-2-yl, Br), (M-6948, Cl, H, F, pyrrazol-2-yl, CH.sub.3),
(M-6949, Cl, H, F, pyrrazol-3-yl, H), (M-6950, Cl, H, F,
pyrrazol-3-yl, Cl), (M-6951, Cl, H, F, pyrrazol-3-yl, F), (M-6952,
Cl, H, F, pyrrazol-3-yl, CF.sub.3), (M-6953, Cl, H, F,
pyrrazol-3-yl, Br), (M-6954, Cl, H, F, pyrrazol-3-yl, CH.sub.3),
(M-6955, Cl, H, F, pyrimidin-2-yl, H), (M-6956, Cl, H, F,
pyrimidin-2-yl, Cl), (M-6957, Cl, H, F, pyrimidin-2-yl, F),
(M-6958, Cl, H, F, pyrimidin-2-yl, CF.sub.3), (M-6959, Cl, H, F,
pyrimidin-2-yl, Br), (M-6960, Cl, H, F, pyrimidin-2-yl, CH.sub.3),
(M-6961, Cl, H, F, pyrimidin-4-yl, H), (M-6962, Cl, H, F,
pyrimidin-4-yl, Cl), (M-6963, Cl, H, F, pyrimidin-4-yl, F),
(M-6964, Cl, H, F, pyrimidin-4-yl, CF.sub.3), (M-6965, Cl, H, F,
pyrimidin-4-yl, Br), (M-6966, Cl, H, F, pyrimidin-4-yl, CH.sub.3),
(M-6967, Cl, H, F, pyrimidin-5-yl, H), (M-6968, Cl, H, F,
pyrimidin-5-yl, Cl), (M-6969, Cl, H, F, pyrimidin-5-yl, F),
(M-6970, Cl, H, F, pyrimidin-5-yl, CF.sub.3), (M-6971, Cl, H, F,
pyrimidin-5-yl, Br), (M-6972, Cl, H, F, pyrimidin-5-yl, CH.sub.3),
(M-6973, Cl, H, F, HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-6974, Cl,
H, F, HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-6975, Cl, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-6976, Cl, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-6977, Cl, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-6978, Cl, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-6979, Cl, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-6980, Cl, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-6981, Cl, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6982, Cl, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-6983, Cl, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-6984, Cl, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-6985, Cl, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-6986, Cl, H,
F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-6987, Cl,
H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6988,
Cl, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-6989, Cl, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-6990, Cl, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-6991,
Cl, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
H), (M-6992, Cl, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-6993, Cl, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-6994,
Cl, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-6995, Cl, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-6996, Cl, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-6997, Cl, H, F, MeOCH.sub.2, H), (M-6998, Cl, H, F, MeOCH.sub.2,
Cl), (M-6999, Cl, H, F, MeOCH.sub.2, F), (M-7000, Cl, H, F,
MeOCH.sub.2, CF.sub.3), (M-7001, Cl, H, F, MeOCH.sub.2, Br),
(M-7002, Cl, H, F, MeOCH.sub.2, CH.sub.3), (M-7003, Cl, H, F,
EtOCH.sub.2, H), (M-7004, Cl, H, F, EtOCH.sub.2, Cl), (M-7005, Cl,
H, F, EtOCH.sub.2, F), (M-7006, Cl, H, F, EtOCH.sub.2, CF.sub.3),
(M-7007, Cl, H, F, EtOCH.sub.2, Br), (M-7008, Cl, H, F,
EtOCH.sub.2, CH.sub.3), (M-7009, MeO, H, F, EtOCH
.sub.2CH.sub.2, H), (M-7010, Cl, H, F, EtOCH.sub.2CH.sub.2, Cl),
(M-7011, Cl, H, F, EtOCH.sub.2CH.sub.2, F), (M-7012, Cl, H, F,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-7013, Cl, H, F,
EtOCH.sub.2CH.sub.2, Br), (M-7014, Cl, H, F, EtOCH.sub.2CH.sub.2,
CH.sub.3), (M-7015, Cl, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
H), (M-7016, Cl, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-7017, Cl, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-7018, Cl, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-7019, Cl, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-7020, Cl, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-7021, Cl, H, F, MeOCH.sub.2CH.sub.2, H), (M-7022, Cl, H, F,
MeOCH.sub.2CH.sub.2, Cl), (M-7023, Cl, H, F, MeOCH.sub.2CH.sub.2,
F), (M-7024, Cl, H, F, MeOCH.sub.2CH.sub.2, CF.sub.3), (M-7025, Cl,
H, F, MeOCH.sub.2CH.sub.2, Br), (M-7026, Cl, H, F,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-7027, Cl, H, F, HOCH.sub.2, H),
(M-7028, Cl, H, F, HOCH.sub.2, Cl), (M-7029, Cl, H, F, HOCH.sub.2,
F), (M-7030, Cl, H, F, HOCH.sub.2, CF.sub.3), (M-7031, Cl, H, F,
HOCH.sub.2, Br), (M-7032, Cl, H, F, HOCH.sub.2, CH.sub.3), (M-7033,
Cl, H, F, HOCH.sub.2CH.sub.2, H), (M-7034, Cl, H, F,
HOCH.sub.2CH.sub.2, Cl), (M-7035, Cl, H, F, HOCH.sub.2CH.sub.2, F),
(M-7036, Cl, H, F, HOCH.sub.2CH.sub.2, CF.sub.3), (M-7037, Cl, H,
F, HOCH.sub.2CH.sub.2, Br), (M-7038, Cl, H, F, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-7039, Cl, H, F, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-7040, Cl, H, F, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-7041, Cl, H,
F, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-7042, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7043, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-7044, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-7045, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-7046, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-7047, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-7048, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7049, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-7050, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-7051, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-7052, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-7053, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-7054, Cl, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7055, Cl,
H, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-7056, Cl,
H, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-7057,
Cl, H, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-7058, Cl, H,
F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-7059, Cl, H, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-7060, Cl, H, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-07061, Cl, H, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-7062, Cl, H, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-7063, Cl, H, F,
(Me).sub.2N, H), (M-7064, Cl, H, F, (Me).sub.2N, Cl), (M-7065, Cl,
H, F, (Me).sub.2N, F), (M-7066, Cl, H, F, (Me).sub.2N, CF.sub.3),
(M-7067, Cl, H, F, (Me).sub.2N, Br), (M-7068, Cl, H, F,
(Me).sub.2N, CH.sub.3), (M-7069, Cl, H, F, piperidin-4-yl-methyl,
H), (M-7070, Cl, H, F, piperidin-4-yl-methyl, Cl), (M-7071, Cl, H,
F, piperidin-4-yl-methyl, F), (M-7072, Cl, H, F,
piperidin-4-yl-methyl, CF.sub.3), (M-7073, Cl, H, F,
piperidin-4-yl-methyl, Br), (M-7074, Cl, H, F,
piperidin-4-yl-methyl, CH.sub.3), (M-7075, Cl, H, F,
cyclohexylmethyl, H), (M-7076, Cl, H, F, cyclohexylmethyl, Cl),
(M-7077, Cl, H, F, cyclohexylmethyl, F), (M-7078, Cl, H, F,
cyclohexylmethyl, CF.sub.3), (M-7079, Cl, H, F, cyclohexylmethyl,
Br), (M-7080, Cl, H, F, cyclohexylmethyl, CH.sub.3), (M-7081, Cl,
H, Cl, H, H), (M-7082, Cl, H, Cl, H, Cl), (M-7083, Cl, H, Cl, H,
F), (M-7084, Cl, H, Cl, H, CF.sub.3), (M-7085, Cl, H, Cl, H, Br),
(M-7086, Cl, H, Cl, H, CH.sub.3), (M-7087, Cl, H, Cl, F, H),
(M-7088, Cl, H, Cl, F, Cl), (M-7089, Cl, H, Cl, F, F), (M-7090, Cl,
H, Cl, F, CF.sub.3), (M-7091, Cl, H, Cl, F, Br), (M-7092, Cl, H,
Cl, F, CH.sub.3), (M-7093, MeO, H, Cl, Cl, H), (M-7094, Cl, H, Cl,
Cl, Cl), (M-7095, Cl, H, Cl, Cl, F), (M-7096, Cl, H, Cl, Cl,
CF.sub.3), (M-7097, Cl, H, Cl, Cl, Br), (M-7098, Cl, H, Cl, Cl,
CH.sub.3), (M-7099, Cl, H, Cl, CH.sub.3, H), (M-7100, Cl, H, Cl,
CH.sub.3, Cl), (M-7101, Cl, H, Cl, CH.sub.3, F), (M-7102, Cl, H,
Cl, CH.sub.2, CF.sub.3), (M-7103, Cl, H, Cl, CH.sub.2, Br),
(M-7104, Cl, H, Cl, CH.sub.3, CH.sub.3), (M-7105, Cl, H, Cl, Et,
H), (M-7106, Cl, H, Cl, Et, Cl), (M-7107, Cl, H, Cl, Et, F),
(M-7108, Cl, H, Cl, Et, CF.sub.3), (M-7109, Cl, H, Cl, Et, Br),
(M-7110, Cl, H, Cl, Et, CH.sub.3), (M-7111, Cl, H, Cl, n-Pr, H),
(M-7112, Cl, H, Cl, n-Pr, Cl), (M-7113, Cl, H, Cl, n-Pr, F),
(M-7114, Cl, H, Cl, n-Pr, CF.sub.3), (M-7115, Cl, H, Cl, n-Pr, Br),
(M-7116, Cl, H, Cl, n-Pr, CH.sub.3), (M-7117, Cl, H, Cl, c-Pr, H),
(M-7118, Cl, H, Cl, c-Pr, Cl), (M-7119, Cl, H, Cl, c-Pr, F),
(M-7120, Cl, H, Cl, c-Pr, CF.sub.3), (M-7121, Cl, H, Cl, c-Pr, Br),
(M-7122, Cl, H, Cl, c-Pr, CH.sub.3), (M-7123, Cl, H, Cl, i-Pr, H),
(M-7124, Cl, H, Cl, i-Pr, Cl), (M-7125, Cl, H, Cl, i-Pr, F),
(M-7126, Cl, H, Cl, i-Pr, CF.sub.3), (M-7127, Cl, H, Cl, i-Pr, Br),
(M-7128, Cl, H, Cl, i-Pr, CH.sub.3), (M-7129, Cl, H, Cl, n-Bu, H),
(M-7130, Cl, H, Cl, n-Bu, Cl), (M-7131, Cl, H, Cl, n-Bu, F),
(M-7132, Cl, H, Cl, n-Bu, CF.sub.3), (M-7133, Cl, H, Cl, n-Bu, Br),
(M-7134, Cl, H, Cl, n-Bu, CH.sub.3), (M-7135, Cl, H, Cl, i-Bu, H),
(M-7136, Cl, H, Cl, i-Bu, Cl), (M-7137, Cl, H, Cl, i-Bu, F),
(M-7138, Cl, H, Cl, i-Bu, CF.sub.3), (M-7139, Cl, H, Cl, i-Bu, Br),
(M-7140, Cl, H, Cl, i-Bu, CH.sub.3), (M-7141, Cl, H, Cl, sec-Bu,
H), (M-7142, Cl, H, Cl, sec-Bu, Cl), (M-7143, Cl, H, Cl, sec-Bu,
F), (M-7144, Cl, H, Cl, sec-Bu, CF.sub.3), (M-7145, Cl, H, Cl,
sec-Bu, Br), (M-7146, Cl, H, Cl, sec-Bu, CH.sub.3), (M-7147, Cl, H,
Cl, n-Pen, H), (M-7148, Cl, H, Cl, n-Pen, Cl), (M-7149, Cl, H, Cl,
n-Pen, F), (M-7150, Cl, H, Cl, n-Pen, CF.sub.3), (M-7151, Cl, H,
Cl, n-Pen, Br), (M-7152, Cl, H, Cl, n-Pen, CH.sub.3), (M-7153, Cl,
H, Cl, c-Pen, H), (M-7154, Cl, H, Cl, c-Pen, Cl), (M-7155, Cl, H,
Cl, c-Pen, F), (M-7156, Cl, H, Cl, c-Pen, CF.sub.3), (M-7157, Cl,
H, Cl, c-Pen, Br), (M-7158, Cl, H, Cl, c-Pen, CH.sub.3), (M-7159,
Cl, H, Cl, n-Hex, H), (M-7160, Cl, H, Cl, n-Hex, Cl), (M-7161, Cl,
H, Cl, n-Hex, F), (M-7162, Cl, H, Cl, n-Hex, CF.sub.3), (M-7163,
Cl, H, Cl, n-Hex, Br), (M-7164, Cl, H, Cl, n-Hex, CH.sub.3),
(M-7165, Cl, H, Cl, c-Hex, H), (M-7166, Cl, H, Cl, c-Hex, Cl),
(M-7167, Cl, H, Cl, c-Hex, F), (M-7168, Cl, H, Cl, c-Hex,
CF.sub.3), (M-7169, Cl, H, Cl, c-Hex, Br), (M-7170, Cl, H, Cl,
c-Hex, CH.sub.3), (M-7171, Cl, H, Cl, OH, H), (M-7172, Cl, H, Cl,
OH, Cl), (M-7173, Cl, H, Cl, OH, F), (M-7174, Cl, H, Cl, OH,
CF.sub.3), (M-7175, Cl, H, Cl, OH, Br), (M-7176, Cl, H, Cl, OH,
CH.sub.3), (M-7177, Cl, H, Cl, EtO, H), (M-7178, Cl, H, Cl, EtO,
Cl), (M-7179, Cl, H, Cl, EtO, F), (M-7180, Cl, H, Cl, EtO,
CF.sub.3), (M-7181, Cl, H, Cl, EtO, Br), (M-7182, Cl, H, Cl, EtO,
CH.sub.3), (M-7183, Cl, H, Cl, n-PrO, H), (M-7184, Cl, H, Cl,
n-PrO, Cl), (M-7185, Cl, H, Cl, n-PrO, F), (M-7186, Cl, H, Cl,
n-PrO, CF.sub.3), (M-7187, Cl, H, Cl, n-PrO, Br), (M-7188, Cl, H,
Cl, n-PrO, CH.sub.3), (M-7189, Cl, H, Cl, PhO, H), (M-7190, Cl, H,
Cl, PhO, Cl), (M-7191, Cl, H, Cl, PhO, F), (M-7192, Cl, H, Cl, PhO,
CF.sub.3), (M-7193, Cl, H, Cl, PhO, Br), (M-7194, Cl, H, Cl, PhO,
CH.sub.3), (M-7195, Cl, H, Cl, BnO, H), (M-7196, Cl, H, Cl, BnO,
Cl), (M-7197, Cl, H, Cl, BnO, P), (M-7198, Cl, H, Cl, BnO,
CF.sub.3), (M-7199, Cl, H, Cl, BnO, Br), (M-7200, Cl, H, Cl, BnO,
CH.sub.3), (M-7201, Cl, H, Cl, PhCH.sub.2CH.sub.2O, H), (M-7202,
Cl, H, Cl, PhCH.sub.2CH.sub.2O, Cl), (M-7203, Cl, H, Cl,
PhCH.sub.2CH.sub.2O, F), (M-7204, Cl, H, Cl, PhCH.sub.2CH.sub.2O,
CF.sub.3), (M-7205, Cl, H, Cl, PhCH.sub.2CH.sub.2O, Br), (M-7206,
Cl, H, Cl, PhCH.sub.2CH.sub.2O, CH.sub.3), (M-7207, Cl, H, Cl,
CF.sub.3O, H), (M-7208, Cl, H, Cl, CF.sub.30, Cl), (M-7209, Cl, H,
Cl, CF.sub.3O, F), (M-7210, Cl, H, Cl, CF.sub.3O, CF.sub.3),
(M-7211, Cl, H, Cl, CF.sub.3O, Br), (M-7212, Cl, H, Cl, CF.sub.3O,
CH.sub.3), (M-7213, Cl, H, Cl, Ph, H), (M-7214, Cl, H, Cl, Ph, Cl),
(M-7215, Cl, H, Cl, Ph, F), (M-7216, Cl, H, Cl, Ph, CF.sub.3),
(M-7217, Cl, H, Cl, Ph, Br), (M-7218, Cl, H, Cl, Ph, CH.sub.3),
(M-7219, Cl, H, Cl, 4-F-Ph, H), (M-7220, Cl, H, Cl, 4-F-Ph, Cl),
(M-7221, Cl, H, Cl, 4-F-Ph, F), (M-7222, Cl, H, Cl, 4-F-Ph,
CF.sub.3), (M-7223, Cl, H, Cl, 4-F-Ph, Br), (M-7224, Cl, H, Cl,
4-F-Ph, CH.sub.3), (M-7225, Cl, H, Cl, 4-CF.sub.3-Ph, H), (M-7226,
Cl, H, Cl, 4-CF.sub.3-Ph, Cl), (M-7227, Cl, H, Cl, 4-CF.sub.3-Ph,
F), (M-7228, Cl, H, Cl, 4-CF.sub.3-Ph, CF.sub.3), (M-7229, Cl, H,
Cl, 4-CF.sub.3-Ph, Br), (M-7230, Cl, H, Cl, 4-CF.sub.3-Ph,
CH.sub.3), (M-7231, Cl, H, Cl, 4-(Me).sub.2N-Ph, H), (M-7232, Cl,
H, Cl, 4-(Me).sub.2N-Ph, Cl), (M-7233, Cl, H, Cl, 4-(Me).sub.2N-Ph,
F), (M-7234, Cl, H, Cl, 4-(Me).sub.2N-Ph, CF.sub.3), (M-7235, Cl,
H, Cl, 4-(Me).sub.2N-Ph, Br), (M-7236, Cl, H, Cl, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-7237, Cl, H, Cl, 4-OH-Ph, H), (M-7238, Cl, H, Cl,
4-OH-Ph, Cl), (M-7239, Cl, H, Cl, 4-OH-Ph, F), (M-7240, Cl, H, Cl,
4-OH-Ph, CF.sub.3), (M-7241, Cl, H, Cl, 4-OH-Ph, Br), (M-7242, Cl,
H, Cl, 4-OH-Ph, CH.sub.3), (M-7243, Cl, H, Cl, 3,4-di-F-Ph, H),
(M-7244, Cl, H, Cl, 3,4-di-F-Ph, Cl), (M-7245, Cl, H, Cl,
3,4-di-F-Ph, F), (M-7246, Cl, H, Cl, 3,4-di-F-Ph, CF.sub.3),
(M-7247, Cl, H, Cl, 3,4-di-F-Ph, Br), (M-7248, Cl, Ft, Cl,
3,4-di-F-Ph, CH.sub.3), (M-7249, Cl, H, Cl, 4-COOH-Ph, H), (M-7250,
Cl, H, Cl, 4-COOH-Ph, Cl), (M-7251, Cl, H, Cl, 4-COOH-Ph, F),
(M-7252, Cl, H, Cl, 4-COOH-Ph, CF.sub.3), (M-7253, Cl, H, Cl,
4-COOH-Ph, Br), (M-7254, Cl, H, Cl, 4-COOH-Ph, CH.sub.3), (M-7255,
Cl, H, Cl, Bn, H), (M-7256, Cl, H, Cl, Bn, Cl), (M-7257, Cl, H, Cl,
Bn, F), (M-7258, Cl, H, Cl, Bn, CF.sub.3), (M-7259, Cl, H, Cl, Bn,
Br), (M-7260, Cl, H, Cl, Bn, CH.sub.3), (M-7261, Cl, H, Cl, 4-F-Bn,
H), (M-7262, Cl, H, Cl, 4-F-Bn, Cl), (M-7263, Cl, H, Cl, 4-F-Bn,
F), (M-7264, Cl, H, Cl, 4-F-Bn, CF.sub.3), (M-7265, Cl, H, Cl,
4-F-Bn, Br), (M-7266, Cl, H, Cl, 4-F-Bn, CH.sub.3), (M-7267, Cl, H,
Cl, 2-Py, H), (M-7268, Cl, H, Cl, 2-Py, Cl), (M-7269, Cl, H, Cl,
2-Py, F), (M-7270, Cl, H, Cl, 2-Py, CF.sub.3), (M-7271, Cl, H, Cl,
2-Py, Br), (M-7272, Cl, H, Cl, 2-Py, CH.sub.3), (M-7273, Cl, H, Cl,
3-Py, H), (M-7274, Cl, H, Cl, 3-Py, Cl), (M-7275, Cl, H, Cl, 3-Py,
F), (M-7276, Cl, H, Cl, 3-Py, CF.sub.3), (M-7277, Cl, H, Cl, 3-Py,
Br), (M-7278, Cl, H, Cl, 3-Py, CH.sub.3), (M-7279, Cl, H, Cl, 4-Py,
H), (M-7280, Cl, H, Cl, 4-Py, Cl), (M-7281, Cl, H, Cl, 4-Py, F),
(M-7282, Cl, H, Cl, 4-Py, CF.sub.3), (M-7283, Cl, H, Cl, 4-Py, Br),
(M-7284, Cl, H, Cl, 4-Py, CH.sub.3), (M-7285, Cl, H, Cl, 2-Th, H),
(M-7286, Cl, H, Cl, 2-Th, Cl), (M-7287, Cl, H, Cl, 2-Th, F),
(M-7288, Cl, H, Cl, 2-Th, CF.sub.3), (M-7289, Cl, H, Cl, 2-Th, Br),
(M-7290, Cl, H, Cl, 2-Th, CH.sub.3), (M-7291, Cl, H, Cl, 3-Th, H),
(M-7292, Cl, H, Cl, 3-Th, Cl), (M-7293, Cl, H, Cl, 3-Th, F),
(M-7294, Cl, H, Cl, 3-Th, CF.sub.3), (M-7295, Cl, H, Cl, 3-Th, Br),
(M-7296, Cl, H, Cl, 3-Th, CH.sub.3), (M-7297, Cl, H, Cl,
pyrrazol-2-yl, H), (M-7298, Cl, H, Cl, pyrrazol-2-yl, Cl), (M-7299,
Cl, H, Cl, pyrrazol-2-yl, F), (M-7300, Cl, H, Cl, pyrrazol-2-yl,
CF.sub.3), (M-7301, Cl, H, Cl, pyrrazol-2-yl, Br), (M-7302, Cl, H,
Cl, pyrrazol-2-yl, CH.sub.3), (M-7303, Cl, H, Cl, pyrrazol-3-yl,
H), (M-7304, Cl, H, Cl, pyrrazol-3-yl, Cl), (M-7305, Cl, H, Cl,
pyrrazol-3-yl, F), (M-7306, Cl, H, Cl, pyrrazol-3-yl, CF.sub.3),
(M-7307, Cl, H, Cl, pyrrazol-3-yl, Br), (M-7308, Cl, H, Cl,
pyrrazol-3-yl, CH.sub.3), (M-7309, Cl, H, Cl, pyrimidin-2-yl, H),
(M-7310, Cl, H, Cl, pyrimidin-2-yl, Cl), (M-7311, Cl, H, Cl,
pyrimidin-2-yl, F), (M-7312, Cl, H, Cl, pyrimidin-2-yl, CF.sub.3),
(M-7313, Cl, H, Cl, pyrimidin-2-yl, Br), (M-7314, Cl, H, Cl,
pyrimidin-2-yl, CH.sub.3), (M-7315, Cl, H, Cl, pyrimidin-4-yl, H),
(M-7316, Cl, H, Cl, pyrimidin, 4-yl, Cl), (M-7317, Cl, H, Cl,
pyrimidin-4-yl, F), (M-7318, Cl, H, Cl, pyrimidin-4-yl, CF.sub.3),
(M-7319, Cl, H, Cl, pyrimidin-4-yl, Br), (M-7320, Cl, H, Cl,
pyrimidin-4-yl, CH.sub.3), (M-7321, Cl, H, Cl, pyrimidin-5-yl, H),
(M-7322, Cl, H, Cl, pyrimidin-5-yl, Cl), (M-7323, Cl, H, Cl,
pyrimidin-5-yl, F), (M-7324, Cl, H, Cl, pyrimidin-5-yl, CF.sub.3),
(M-7325, Cl, H, Cl, pyrimidin-5-yl, Br), (M-7326, Cl, H, Cl,
pyrimidin-5-yl, CH.sub.3), (M-7327, Cl, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-7328, Cl, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-7329, Cl, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-7330, Cl, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7331, Cl, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-7332, Cl, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-7333, Cl, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-7334, Cl, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-7335, Cl, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-7336, Cl, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7337, Cl, H,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-7338, Cl, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-7339, Cl, H,
Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-7340, Cl,
H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-7341,
Cl, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-7342, Cl, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-7343, Cl, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-7344, Cl, B,
Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-7345, Cl, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-7346,
Cl, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Cl), (M-7347, Cl, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-7348,
Cl, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-7349, Cl, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-7350, Cl, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-7351, Cl, H, Cl, MeOCH.sub.2, H), (M-7352, Cl, H, Cl,
MeOCH.sub.2, Cl), (M-7353, Cl, H, Cl, MeOCH.sub.2, F), (M-7354, Cl,
H, Cl, MeOCH.sub.2, CF.sub.3), (M-7355, Cl, H, Cl, MeOCH.sub.2,
Br), (M-7356, Cl, H, Cl, MeOCH.sub.2, CH.sub.3), (M-7357, Cl, H,
Cl, EtOCH.sub.2, H), (M-7358, Cl, H, Cl, EtOCH.sub.2, Cl), (M-7359,
Cl, H, Cl, EtOCH.sub.2, F), (M-7360, Cl, H, Cl, EtOCH.sub.2,
CF.sub.3), (M-7361, Cl, H, Cl, EtOCH.sub.2, Br), (M-7362, Cl, H,
Cl, EtOCH.sub.2, CH.sub.3), (M-7363, Cl, H, Cl,
EtOCH.sub.2CH.sub.2, H), (M-7364, Cl, H, Cl, EtOCH.sub.2CH.sub.2,
Cl), (M-7365, Cl, H, Cl, EtOCH.sub.2CH.sub.2, F), (M-7366, Cl, H,
Cl, EtOCH.sub.2CH.sub.2, CF.sub.3), (M-7367, Cl, H, Cl,
EtOCH.sub.2CH.sub.2, Br), (M-7368, Cl, H, Cl, EtOCH.sub.2CH.sub.2,
CH.sub.3), (M-7369, Cl, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-7370, Cl, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-7371, Cl, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-7372, Cl, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3
), (M-7373, Cl, H, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-7374, Cl, H, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-7375, Cl, H, Cl, MeOCH.sub.2CH.sub.2, H), (M-7376,
Cl, H, Cl, MeOCH.sub.2CH.sub.2, Cl), (M-7377, Cl, H, Cl,
MeOCH.sub.2CH.sub.2, F), (M-7378, Cl, H, Cl, MeOCH.sub.2CH.sub.2,
CF.sub.3), (M-7379, Cl, H, Cl, MeOCH.sub.2CH.sub.2, Br), (M-7380,
Cl, H, Cl, MeOCH.sub.2CH.sub.2, CH.sub.3), (M-7381, Cl, H, Cl,
HOCH.sub.2, H), (M-7382, Cl, H, Cl, HOCH.sub.2, Cl), (M-7383, Cl,
H, Cl, HOCH.sub.2, F), (M-7384, Cl, H, Cl, HOCH.sub.2, CF.sub.3),
(M-7385, Cl, H, Cl, HOCH.sub.2, Br), (M-7386, Cl, H, Cl,
HOCH.sub.2, CH.sub.3), (M-7387, Cl, H, Cl, HOCH.sub.2CH.sub.2, H),
(M-7388, Cl, H, Cl, HOCH.sub.2CH.sub.2, Cl), (M-7389, Cl, H, Cl,
HOCH.sub.2CH.sub.2, F), (M-7390, Cl, H, Cl, HOCH.sub.2CH.sub.2,
CF.sub.3), (M-7391, Cl, H, Cl, HOCH.sub.2CH.sub.2, Br), (M-7392,
Cl, H, Cl, HOCH.sub.2CH.sub.2, CH.sub.3), (M-7393, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-7394, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-7396, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-7396, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7397, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-7398, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-7399, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-7400, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-7401, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-7402, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7403, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-7404, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-7405, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-7406, Cl, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-7407, Cl, H,
Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-7408, Cl, H,
Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7409,
Cl, H, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-7410, Cl, H, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-7411, Cl, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
H), (M-7412, Cl, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-7413, Cl, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-7414, Cl, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-7415, Cl, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-7416, Cl, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-7417, Cl, H, Cl, (Me).sub.2N, H), (M-7418, Cl, H, Cl,
(Me).sub.2N, Cl), (M-7419, Cl, H, Cl, (Me).sub.2N, F), (M-7420, Cl,
H, Cl, (Me).sub.2N, CF.sub.3), (M-7421, Cl, H, Cl, (Me).sub.2N,
Br), (M-7422, Cl, H, Cl, (Me).sub.2N, CH.sub.3), (M-7423, Cl, H,
Cl, piperidin-4-yl-methyl, H), (M-7424, Cl, H, Cl,
piperidin-4-yl-methyl, Cl), (M-7425, Cl, H, Cl,
piperidin-4-yl-methyl, F), (M-7426, Cl, H, Cl,
piperidin-4-yl-methyl, CF.sub.3), (M-7427, Cl, H, Cl,
piperidin-4-yl-methyl, Br), (M-7428, Cl, H, Cl,
piperidin-4-yl-methyl, CH.sub.3), (M-7429, Cl, H, Cl,
cyclohexylmethyl, H), (M-7430, Cl, H, Cl, cyclohexylmethyl, Cl),
(M-7431, Cl, H, Cl, cyclohexylmethyl, F), (M-7432, Cl, H, Cl,
cyclohexylmethyl, CF.sub.3), (M-7433, Cl, H, Cl, cyclohexylmethyl,
Br), (M-7434, Cl, H, Cl, cyclohexylmethyl, CH.sub.3), (M-7435, Cl,
F, H, H, H), (M-7436, Cl, F, H, H, Cl), (M-7437, Cl, F, H, H, F),
(M-7438, Cl, F, H, H, CF.sub.3), (M-7439, Cl, F, H, H, Br),
(M-7440, Cl, F, H, H, CH.sub.3), (M-7441, Cl, F, H, F, H), (M-7442,
Cl, F, H, F, Cl), (M-7443, Cl, F, H, F, F), (M-7444, Cl, F, H, F,
CF.sub.3), (M-7445, Cl, F, H, F, Br), (M-7446, Cl, F, H, F,
CH.sub.3), (M-7447, Cl, F, H, Cl, H), (M-7448, Cl, F, H, Cl, Cl),
(M-7449, Cl, F, H, Cl, F), (M-7450, Cl, F, H, Cl, CF.sub.3),
(M-7451, Cl, F, H, Cl, Br), (M-7452, Cl, F, H, Cl, CH.sub.3),
(M-7453, Cl, F, H, CH.sub.3, H), (M-7454, Cl, F, H, CH.sub.3, Cl),
(M-7455, Cl, F, H, CH.sub.3, F), (M-7456, Cl, F, H, CH.sub.3,
CF.sub.3), (M-7457, Cl, F, H, CH.sub.3, Br), (M-7458, Cl, F, H,
CH.sub.3, CH.sub.3), (M-7459, Cl, F, H, Et, H), (M-7460, Cl, F, H,
Et, Cl), (M-7461, Cl, F, H, Et, F), (M-7462, Cl, F, H, Et,
CF.sub.2), (M-7463, Cl, F, H, Et, Br), (M-7464, Cl, F, H, Et,
CH.sub.3), (M-7465, Cl, F, H, n-Pr, H), (M-7466, Cl, F, H, n-Pr,
Cl), (M-7467, Cl, F, H, n-Pr, F), (M-7468, Cl, F, H, n-Pr,
CF.sub.3), (M-7469, Cl, F, H, n-Pr, Br), (M-7470, Cl, F, H, n-Pr,
CH.sub.3), (M-7471, Cl, F, H, c-Pr, H), (M-7472, Cl, F, H, c-Pr,
Cl), (M-7473, Cl, F, H, c-Pr, F), (M-7474, Cl, F, H, c-Pr,
CF.sub.3), (M-7475, Cl, F, H, c-Pr, Br), (M-7476, Cl, F, H, c-Pr,
CH.sub.3), (M-7477, Cl, F, H, i-Pr, H), (M-7478, Cl, F, H, i-Pr,
Cl), (M-7479, Cl, F, H, i-Pr, F), (M-7480, Cl, F, H, i-Pr,
CF.sub.3), (M-7481, Cl, F, ft, i-Pr, Br), (M-7482, Cl, F, H, i-Pr,
CH.sub.3), (M-7483, MeO, F, H, n-Bu, H), (M-7484, Cl, F, H, n-Bu,
Cl), (M-7480, Cl, F, H, n-Bu, F), (M-7486, Cl, F, H, n-Bu,
CF.sub.3), (M-7487, Cl, F, H, n-Bu, Br), (M-7488, Cl, F, H, n-Bu,
CH.sub.3), (M-7489, Cl, F, H, i-Bu, H), (M-7490, Cl, F, H, i-Bu,
Cl), (M-7491, Cl, F, H, i-Bu, F), (M-7492, Cl, F, H, i-Bu,
CF.sub.3), (M-7493, Cl, F, H, i-Bu, Br), (M-7494, Cl, F, H, i-Bu,
CH.sub.3), (M-7495, Cl, F, H, sec-Bu, H), (M-7496, Cl, F, H,
sec-Bu, Cl), (M-7497, Cl, F, H, sec-Bu, F), (M-7498, Cl, F, H,
sec-Bu, CF.sub.3), (M-7499, Cl, F, H, sec-Bu, Br), (M-7500, Cl, F,
H, sec-Bu, CH.sub.3), (M-7501, Cl, F, H, n-Pen, H), (M-7502, Cl, F,
H, n-Pen, Cl), (M-7503, Cl, F, H, n-Pen, F), (M-7504, Cl, F, H,
n-Pen, CF.sub.3), (M-7505, Cl, F, H, n-Pen, Br), (M-7506, CL F, H,
n-Pen, CH.sub.3), (M-7507, Cl, F, H, c-Pen, H), (M-7508, Cl, F, H,
c-Pen, Cl), (M-7509, Cl, F, H, c-Pen, F), (M-7510, Cl, F, H, c-Pen,
CF.sub.3), (M-7511, Cl, F, H, c-Pen, Br), (M-7512, Cl, F, H, c-Pen,
CH.sub.3), (M-7513, Cl, F, H, n-Hex, H), (M-7514, Cl, F, H, n-Hex,
Cl), (M-7515, Cl, F, H, n-Hex, F), (M-7516, Cl, F, H, n-Hex,
CF.sub.3), (M-7517, Cl, F, H, n-Hex, Br), (M-7518, Cl, F, H, n-Hex,
CH.sub.3), (M-7519, Cl, F, H, c-Hex, H), (M-7520, Cl, F, H, c-Hex,
Cl), (M-7521, Cl, F, H, c-Hex, F), (M-7522, Cl, F, H, c-Hex,
CF.sub.3), (M-7523, Cl, F, H, c-Hex, Br), (M-7524, Cl, F, H, c-Hex,
CH.sub.3), (M-7525, Cl, F, H, OH, H), (M-7526, Cl, F, H, OH, Cl),
(M-7527, Cl, F, H, OH, F), (M-7528, Cl, F, H, OH, CF.sub.3),
(M-7529, Cl, F, H, OH, Br), (M-7530, Cl, F, H, OH, CH.sub.3),
(M-7531, Cl, F, H, EtO, H), (M-7532, Cl, F, H, EtO, Cl), (M-7533,
Cl, F, H, EtO, F), (M-7534, C), F, H, EtO, CF.sub.3), (M-7535, Cl,
F, H, EtO, Br), (M-7536, Cl, F, H, EtO, CH.sub.3), (M-7537, Cl, F,
H, n-PrO, H), (M-7538, Cl, F, H, n-PrO, Cl), (M-7539, Cl, F, H,
n-PrO, F), (M-7540, Cl, F, H, n-PrO, CF.sub.3), (M-7541, Cl, F, H,
n-PrO, Br), (M-7542, Cl, F, H, n-PrO, CH.sub.3), (M-7543, Cl, F, H,
PhO, H), (M-7544, Cl, F, H, PhO, Cl), (M-7545, Cl, F, H, PhO, F),
(M-7546, Cl, F, H, PhO, CF.sub.3), (M-7547, Cl, F, H, PhO, Br),
(M-7548, Cl, F, H, PhO, CH.sub.3), (M-7549, Cl, F, H, BnO, H),
(M-7550, Cl, F, H, BnO, Cl), (M-7551, Cl, F, H, BnO, F), (M-7552,
Cl, F, H, BnO, CF.sub.3), (M-7553, Cl, F, H, BnO, Br), (M-7554, Cl,
F, H, BnO, CH.sub.3), (M-7555, Cl, F, H, PhCH.sub.2CH.sub.2O, H),
(M-7556, Cl, F, H, PhCH.sub.2CH.sub.2O, Cl), (M-7557, Cl, F, H,
PhCH.sub.2CH.sub.2O, F), (M-7558, Cl, F, H, PhCH.sub.2CH.sub.2O,
CF.sub.3), (M-7559, Cl, F, H, PhCH.sub.2CH.sub.2O, Br), (M-7560,
Cl, F, H, PhCH.sub.2CH.sub.2O, CH.sub.3), (M-7561, Cl, F, H,
CF.sub.3O, H), (M-7562, Cl, F, H, CF.sub.3O, Cl), (M-7563, Cl, F,
H, CF.sub.3O, F), (M-7564, Cl, F, H, CF.sub.3O, CF.sub.3), (M-7565,
Cl, F, H, CF.sub.3O, Br), (M-7566, Cl, F, H, CF.sub.3O, CH.sub.3),
(M-7567, Cl, F, H, Ph, H), (M-7568, Cl, F, H, Ph, Cl), (M-7569, Cl,
F, H, Ph, F), (M-7570, Cl, F, H, Ph, CF.sub.3), (M-7571, Cl, F, H,
Ph, Br), (M-7572, Cl, F, H, Ph, CH.sub.3), (M-7573, Cl, F, H,
4-F-Ph, H), (M-7574, Cl, F, H, 4-F-Ph, Cl), (M-7575, Cl, F, H,
4-F-Ph, F), (M-7576, Cl, F, H, 4-F-Ph, CF.sub.3), (M-7577, Cl, F,
H, 4-F-Ph, Br), (M-7578, Cl, F, H, 4-F-Ph, CH.sub.3), (M-7579, Cl,
F, H, 4-CF.sub.3-Ph, H), (M-7580, Cl, F, H, 4-CF.sub.3-Ph, Cl),
(M-7581, Cl, F, H, 4-CF.sub.3-Ph, F), (M-7582, Cl, F, H,
4-CF.sub.3-Ph, CF.sub.3), (M-7583, Cl, F, H, 4-CF.sub.3-Ph, Br),
(M-7584, Cl, F, H, 4-CF.sub.3-Ph, CH.sub.3), (M-7585, Cl, F, H,
4-(Me).sub.2N-Ph, H), (M-7586, Cl, F, H, 4-(Me).sub.2N-Ph, Cl),
(M-7587, Cl, F, H, 4-(Me).sub.2N-Ph, F), (M-7588, Cl, F, H,
4-(Me).sub.2N-Ph, CF.sub.3), (M-7589, Cl, F, H, 4-(Me).sub.2N-Ph,
Br), (M-7590, Cl, F, H, 4-(Me).sub.2N-Ph, CH.sub.3), (M-7591, Cl,
F, H, 4-OH-Ph, H), (M-7592, Cl, F, H, 4-OH-Ph, Cl), (M-7593, Cl, F,
H, 4-OH-Ph, F), (M-7594, Cl, F, H, 4-OH-Ph, CF.sub.3), (M-7595, Cl,
F, H, 4-OH-Ph, Br), (M-7596, Cl, F, H, 4-OH-Ph, CH.sub.3), (M-7597,
Cl, F, H, 3,4-di-F-Ph, H), (M-7598, Cl, F, H, 3,4-di-F-Ph, Cl),
(M-7599, Cl, F, H, 3,4-di-F-Ph, F), (M-7600, Cl, F, H, 3,4-di-F-Ph,
CF.sub.3), (M-7601, Cl, F, H, 3,4-di-F-Ph, Br), (M-7602, Cl, F, H,
3,4-di-F-Ph, CH.sub.3), (M-7603, Cl, F, H, 4-COOH-Ph, H), (M-7604,
Cl, F, H, 4-COOH-Ph, Cl), (M-7605, Cl, F, H, 4-COOH-Ph, F),
(M-7606, Cl, F, H, 4-COOH-Ph, CF.sub.3), (M-7607, Cl, F, H,
4-COOH-Ph, Br), (M-7608, Cl, F, H, 4-COOH-Ph, CH.sub.3), (M-7609,
Cl, F, H, Bn, H), (M-7610, Cl, F, H, Bn, Cl), (M-7611, Cl, F, H,
Bn, F), (M-7612, Cl, F, H, Bn, CF.sub.3), (M-7613, Cl, F, H, Bn,
Br), (M-7614, Cl, F, H, Bn, CH.sub.3), (M-7615, Cl, F, H, 4-F-Bn,
H), (M-7616, Cl, F, H, 4-F-Bn, Cl), (M-7617, Cl, F, H, 4-F-Bn, F),
(M-7618, Cl, F, H, 4-F-Bn, CF.sub.3), (M-7619, Cl, F, H, 4-F-Bn,
Br), (M-7620, Cl, F, H, 4-F-Bn, CH.sub.3), (M-7621, Cl, F, H, 2-Py,
H), (M-7622, Cl, F, H, 2-Py, Cl), (M-7623, Cl, F, H, 2-Py, F),
(M-7624, Cl, F, H, 2-Py, CF.sub.3), (M-7625, Cl, F, H, 2-Py, Br),
(M-7626, Cl, F, H, 2-Py, CH.sub.3), (M-7627, Cl, F, H, 3-Py, H),
(M-7628, Cl, F, H, 3-Py, Cl), (M-7629, Cl, F, H, 3-Py, F), (M-7630,
Cl, F, H, 3-Py, CF.sub.3), (M-7631, Cl, F, H, 3-Py, Br), (M-7632,
Cl, F, H, 3-Py, CH.sub.3), (M-7633, Cl, F, H, 4-Py, H), (M-7634,
Cl, F, H, 4-Py, Cl), (M-7635, Cl, F, H, 4-Py, F), (M-7636, Cl, F,
H, 4-Py, CF.sub.3), (M-7637, Cl, F, H, 4-Py, Br), (M-7638, Cl, F,
H, 4-Py, CH.sub.3), (M-7639, Cl, F, H, 2-Th, H), (M-7640, Cl, F, H,
2-Th, Cl), (M-7641, Cl, F, H, 2-Th, F), (M-7642, Cl, F, H, 2-Th,
CF.sub.3), (M-7643, Cl, F, H, 2-Th, Br), (M-7644, Cl, F, H, 2-Th,
CH.sub.3), (M-7645, Cl, F, H, 3-Th, H), (M-7646, Cl, F, H, 3-Th,
Cl), (M-7647, Cl, F, H, 3-Th, F), (M-7648, Cl, F, H, 3-Th,
CF.sub.3), (M-7649, Cl, F, H, 3-Th, Br), (M-7650, Cl, F, H, 3-Th,
CH.sub.3), (M-7651, Cl, F, H, pyrrazol-2-yl, H), (M-7652, Cl, F, H,
pyrrazol-2-yl, Cl), (M-7653, Cl, F, H, pyrrazol-2-yl, F), (M-7654,
Cl, F, H, pyrrazol-2-yl, CF.sub.3), (M-7655, Cl, F, H,
pyrrazol-2-yl, Br), (M-7656, Cl, F, H, pyrrazol-2-yl, CH.sub.3),
(M-7657, Cl, F, H, pyrrazol-3-yl, H), (M-7658, Cl, F, H,
pyrrazol-3-yl, Cl), (M-7659, Cl, F, H, pyrrazol-3-yl, F), (M-7660,
Cl, F, H, pyrrazol-3-yl, CF.sub.3), (M-7661, Cl, F, H,
pyrrazol-3-yl, Br), (M-7662, Cl, F, H, pyrrazol-3-yl, CH.sub.3),
(M-7663, Cl, F, H, pyrimidin-2-yl, H), (M-7664, Cl, F, H,
pyrimidin-2-yl, Cl), (M-7665, Cl, F, H, pyrimidin-2-yl, F),
(M-7666, Cl, F, H, pyrimidin-2-yl, CF.sub.3), (M-7667, Cl, F, H,
pyrimidin-2-yl, Br), (M-7668, Cl, F, H, pyrimidin-2-yl, CH.sub.3),
(M-7669, Cl, F, H, pyrimidin-4-yl, H), (M-7670, Cl, F, H,
pyrimidin-4-yl, Cl), (M-7671, Cl, F, H, pyrimidin-4-yl, F),
(M-7672, Cl, F, H, pyrimidin-4-yl, CF.sub.3), (M-7673, Cl, F, H,
pyrimidin-4-yl, Br), (M-7674, Cl, F, H, pyrimidin-4-yl, CH.sub.3),
(M-7675, Cl, F, H, pyrimidin-5-yl, H), (M-7676, Cl, F, H,
pyrimidin-5-yl, Cl), (M-7677, Cl, F, H, pyrimidin-5-yl, F),
(M-7678, Cl, F, H, pyrimidin-5-yl, CF.sub.3), (M-7679, Cl, F, H,
pyrimidin-5-yl, Br), (M-7680, Cl, F, H, pyrimidin-5-yl, CH.sub.3),
(M-7681, Cl, F, H, HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-7682, Cl,
F, H, HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-7683, Cl, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-7684, Cl, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7685, Cl, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-7686, Cl, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-7687, Cl, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-7688, Cl, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-7689, Cl, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-7690, Cl, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7691, Cl, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-7692, Cl, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-7693, Cl, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-7694, Cl, F,
H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-7695, Cl,
F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-7696,
Cl, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-7697, Cl, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-7698, Cl, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-7699,
Cl, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
H), (M-7700, Cl, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-7701, Cl, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-7702,
Cl, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-7703, Cl, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-7704, Cl, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-7705, Cl, F, H, MeOCH.sub.2, H), (M-7706, Cl, F, H, MeOCH.sub.2,
Cl), (M-7707, Cl, F, H, MeOCH.sub.2, F), (M-7708, Cl, F, H,
MeOCH.sub.2, CF.sub.3), (M-7709, Cl, F, H, MeOCH.sub.2, Br),
(M-7710, Cl, F, H, MeOCH.sub.2, CH.sub.3), (M-7711, Cl, F, H,
EtOCH.sub.2, H), (M-7712, Cl, F, H, EtOCH.sub.2, Cl), (M-7713, Cl,
F, H, EtOCH.sub.2, F), (M-7714, Cl, F, H, EtOCH.sub.2, CF.sub.3),
(M-7715, Cl, F, H, EtOCH.sub.2, Br), (M-7716, Cl, F, H,
EtOCH.sub.2, CH.sub.3), (M-7717, Cl, F, H, EtOCH.sub.2CH.sub.2, H),
(M-7718, Cl, F, H, EtOCH.sub.2CH.sub.2, Cl), (M-7719, Cl, F, H,
EtOCH.sub.2CH.sub.2, F), (M-7720, Cl, F, H, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-7721, Cl, F, H, EtOCH.sub.2CH.sub.2, Br), (M-7722,
Cl, F, H, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-7723, Cl, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-7724, Cl, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-7725, Cl, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-7726, Cl, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-7727, Cl, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-7728, Cl, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-7729, Cl, F, H,
MeOCH.sub.2CH.sub.2, H), (M-7730, Cl, F, H, MeOCH.sub.2CH.sub.2,
Cl), (M-7731, Cl, F, H, MeOCH.sub.2CH.sub.2, F), (M-7732, Cl, F, H,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-7733, Cl, F, H,
MeOCH.sub.2CH.sub.2, Br), (M-7734, Cl, F, H, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-7735, Cl, F, H, HOCH.sub.2, H), (M-7736, Cl, F, H,
HOCH.sub.2, Cl), (M-7737, Cl, F, H, HOCH.sub.2, F), (M-7738, Cl, F,
H, HOCH.sub.2, CF.sub.3), (M-7739, Cl, F, H, HOCH.sub.2, Br),
(M-7740, Cl, F, H, HOCH.sub.2, CH.sub.3), (M-7741, Cl, F, H,
HOCH.sub.2CH.sub.2, H), (M-7742, Cl, F, H, HOCH.sub.2CH.sub.2, Cl),
(M-7743, Cl, F, H, HOCH
.sub.2CH.sub.2, F), (M-7744, Cl, F, H, HOCH.sub.2CH.sub.2,
CF.sub.3), (M-7745, Cl, F, H, HOCH.sub.2CH.sub.2, Br), (M-7746, Cl,
F, H, HOCH.sub.2CH.sub.2, CH.sub.3), (M-7747, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-7748, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-7749, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-7750, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7751, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-7752, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-7753, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-7754, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-7755, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-7756, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-7757, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-7758, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-7759, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-7760, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-7761, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-7762, Cl, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-7763, Cl,
F, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-7764, Cl,
F, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-7765,
Cl, F, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-7766, Cl, F,
H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-7767, Cl, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-7768, Cl, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-7769, Cl, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-7770, Cl, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-7771, Cl, F, H,
(Me).sub.2N, H), (M-7772, Cl, F, H, (Me).sub.2N, Cl), (M-7773, Cl,
F, H, (Me).sub.2N, F), (M-7774, Cl, F, H, (Me).sub.2N, CF.sub.3),
(M-7775, Cl, F, H, (Me).sub.2N, Br), (M-7776, Cl, F, H,
(Me).sub.2N, CH.sub.3), (M-7777, Cl, F, H, piperidin-4-yl-methyl,
H), (M-7778, Cl, F, H, piperidin-4-yl-methyl, Cl), (M-7779, Cl, F,
H, piperidin-4-yl-methyl, F), (M-7780, Cl, F, H,
piperidin-4-yl-methyl, CF.sub.3), (M-7781, Cl, F, H,
piperidin-4-yl-methyl, Br), (M-7782, Cl, F, H,
piperidin-4-yl-methyl, CH.sub.3), (M-7783, Cl, F, H,
cyclohexylmethyl, H), (M-7784, Cl, F, H, cyclohexylmethyl, Cl),
(M-7785, Cl F, H, cyclohexylmethyl, F), (M-7786, Cl, F, H,
cyclohexylmethyl, CF.sub.3), (M-7787, Cl, F, H, cyclohexylmethyl,
Br), (M-7788, Cl, F, H, cyclohexylmethyl, CH.sub.3), (M-7789, Cl,
F, F, H, H), (M-7790, Cl, F, F, H, Cl), (M-7791, Cl, F, F, H, F),
(M-7792, Cl, F, F, H, CF.sub.3), (M-7793, Cl, F, F, H, Br),
(M-7794, Cl, F, F, H, CH.sub.3), (M-7795, Cl, F, F, F, H), (M-7796,
Cl, F, F, F, Cl), (M-7797, Cl, F, F, F, F), (M-7798, Cl, F, F, F,
CF.sub.3), (M-7799, Cl, F, F, F, Br), (M-7800, Cl, F, F, F,
CH.sub.3), (M-7801, Cl, F, F, Cl, H), (M-7802, Cl, F, F, Cl, Cl),
(M-7803, Cl, F, F, Cl, F), (M-7804, Cl, F, F, Cl, CF.sub.3),
(M-7805, Cl, F, F, Cl, Br), (M-7806, Cl, F, F, Cl, CH.sub.3),
(M-7807, Cl, F, F, CH.sub.3, H), (M-7808, Cl, F, F, CH.sub.3, Cl),
(M-7809, Cl, F, F, CH.sub.3, F), (M-7810, Cl, F, F, CH.sub.3,
CF.sub.3), (M-7811, Cl, F, F, CH.sub.3, Br), (M-7812, Cl, F, F,
CH.sub.3, CH.sub.3), (M-7813, Cl, F, F, Et, H), (M-7814, Cl, F, F,
Et, Cl), (M-7815, Cl, F, F, Et, F), (M-7816, Cl, F, F, Et,
CF.sub.3), (M-7817, Cl, F, F, Et, Br), (M-7818, Cl, F, F, Et,
CH.sub.3), (M-7819, Cl, F, F, n-Pr, H), (M-7820, Cl, F, F, n-Pr,
Cl), (M-7821, Cl, F, F, n-Pr, F), (M-7822, Cl, F, F, n-Pr,
CF.sub.3), (M-7823, Cl, F, F, n-Pr, Br), (M-7824, Cl, F, F, n-Pr,
CH.sub.3), (M-7825, Cl, F, F, c-Pr, H), (M-7826, Cl, F, F, c-Pr,
Cl), (M-7827, Cl, F, F, c-Pr, F), (M-7828, Cl, F, F, c-Pr,
CF.sub.3), (M-7829, Cl, F, F, c-Pr, Br), (M-7830, Cl, F, F, c-Pr,
CH.sub.3), (M-7831, Cl, F, F, i-Pr, H), (M-7832, Cl, F, F, i-Pr,
Cl), (M-7833, Cl, F, F, i-Pr, F), (M-7834, Cl, F, F, i-Pr,
CF.sub.3), (M-7835, Cl, F, F, i-Pr, Br), (M-7836, Cl, F, F, i-Pr,
CH.sub.3), (M-7837, Cl, F, F, n-Bu, H), (M-7838, Cl, F, F, n-Bu,
Cl), (M-7839, Cl, F, F, n-Bu, F), (M-7840, Cl, F, F, n-Bu,
CF.sub.3), (M-7841, Cl, F, F, n-Bu, Br), (M-7842, Cl, F, F, n-Bu,
CH.sub.3), (M-7843, Cl, F, F, i-Bu, H), (M-7844, Cl, F, F, i-Bu,
Cl), (M-7845, Cl, F, F, i-Bu, F), (M-7846, Cl, F, F, i-Bu,
CF.sub.3), (M-7847, Cl, F, F, i-Bu, Br), (M-7848, Cl, F, F, i-Bu,
CH.sub.3), (M-7849, Cl, F, F, sec-Bu, H), (M-7850, Cl, F, F,
sec-Bu, Cl), (M-7851, Cl, F, F, sec-Bu, F), (M-7852, Cl, F, F,
sec-Bu, CF.sub.3), (M-7853, Cl, F, F, sec-Bu, Br), (M-7854, Cl, F,
F, sec-Bu, CH.sub.3), (M-7855, Cl, F, F, n-Pen, H), (M-7856, Cl, F,
F, n-Pen, Cl), (M-7857, Cl, F, F, Q-Pen, F), (M-7858, Cl, F, F,
n-Pen, CF.sub.3), (M-7859, Cl, F, F, n-Pen, Br), (M-7860, Cl, F, F,
n-Pen, CH.sub.3), (M-7861, Cl, F, F, c-Pen, H), (M-7862, Cl, F, F,
c-Pen, Cl), (M-7863, Cl, F, F, c-Pen, F), (M-7864, Cl, F, F, c-Pen,
CF.sub.3), (M-7865, Cl, F, F, c-Pen, Br), (M-7866, Cl, F, F, c-Pen,
CH.sub.3), (M-7867, Cl, F, F, n-Hex, H), (M-7868, Cl, F, F, n-Hex,
Cl), (M-7869, Cl, F, F, n-Hex, F), (M-7870, Cl, F, F, n-Hex,
CF.sub.3), (M-7871, Cl, F, F, n-Hex, Br), (M-7872, Cl, F, F, n-Hex,
CH.sub.3), (M-7873, Cl, F, F, c-Hex, H), (M-7874, Cl, F, F, c-Hex,
Cl), (M-7875, Cl, F, F, c-Hex, F), (M-7876, Cl, F, F, c-Hex,
CF.sub.3), (M-7877, Cl, F, F, c-Hex, Br), (M-7878, Cl, F, F, c-Hex,
CH.sub.3), (M-7879, Cl, F, F, OH, H), (M-7880, Cl, F, F, OH, Cl),
(M-7881, Cl, F, F, OH, F), (M-7882, Cl, F, F, OH, CF.sub.3),
(M-7883, Cl, F, F, OH, Br), (M-7884, Cl, F, F, OH, CH.sub.3),
(M-7885, Cl, F, F, EtO, H), (M-7886, Cl, F, F, EtO, Cl), (M-7887,
Cl, F, F, EtO, F), (M-7888, Cl, F, F, EtO, CF.sub.3), (M-7889, Cl,
F, F, EtO, Br), (M-7890, Cl, F, F, EtO, CH.sub.3), (M-7891, Cl, F,
F, n-PrO, H), (M-7892, Cl, F, F, n-PrO, Cl), (M-7893, Cl, F, F,
n-PrO, F), (M-7894, Cl, F, F, n-PrO, CF.sub.3), (M-7895, Cl, F, F,
n-PrO, Br), (M-7896, Cl, F, F, n-PrO, CH.sub.3), (M-7897, Cl, F, F,
PhO, H), (M-7898, Cl, F, F, PhO, Cl), (M-7899, Cl, F, F, PhO, F),
(M-7900, Cl, F, F, PhO, CF.sub.3), (M-7901, Cl, F, F, PhO, Br),
(M-7902, Cl, F, F, PhO, CH.sub.3), (M-7903, Cl, P, F, BnO, H),
(M-7904, Cl, F, F, BnO, Cl), (M-7905, Cl, F, F, BnO, F), (M-7906,
Cl, F, F, BnO, CF.sub.3), (M-7907, Cl, F, F, BnO, Br), (M-7908, Cl,
F, F, BnO, CH.sub.3), (M-7909, Cl, F, F, PhCH.sub.2CH.sub.2O, H),
(M-7910, Cl, F, F, PhCH.sub.2CH.sub.2O, Cl), (M-7911, Cl, F, F,
PhCH.sub.2CH.sub.2O, F), (M-7912, Cl, F, F, PhCH.sub.2CH.sub.2O,
CF.sub.3), (M-7913, Cl, F, F, PhCH.sub.2CH.sub.2O, Br), (M-7914,
Cl, F, F, PhCH.sub.2CH.sub.2O, CH.sub.3), (M-7915, Cl, F, F,
CF.sub.3O, H), (M-7916, Cl, F, F, CF.sub.3O, Cl), (M-7917, Cl, F,
F, CF.sub.3O, F), (M-7918, Cl, F, F, CF.sub.3O, CF.sub.3), (M-7919,
Cl, F, F, CF.sub.3O, Br), (M-7920, Cl, F, F, CF.sub.3O, CH.sub.3),
(M-7921, Cl, F, F, Ph, H), (M-7922, Cl, F, F, Ph, Cl), (M-7923, Cl,
F, F, Ph, F), (M-7924, Cl, F, F, Ph, CF.sub.3), (M-7925, Cl, F, F,
Ph, Br), (M-7926, Cl, F, F, Ph, CH.sub.3), (M-7927, Cl, F, F,
4-F-Ph, H), (M-7928, Cl, F, F, 4-F-Ph, Cl), (M-7929, Cl, F, F,
4-F-Ph, F), (M-7930, Cl, F, F, 4-F-Ph, CF.sub.3), (M-7931, Cl, F,
F, 4-F-Ph, Br), (M-7932, Cl, F, F, 4-F-Ph, CH.sub.3), (M-7933, Cl,
F, F, 4-CF.sub.3-Ph, H), (M-7934, Cl, F, F, 4-CF.sub.3-Ph, Cl),
(M-7935, Cl, F, F, 4-CF.sub.3-Ph, F), (M-7936, Cl, F, F,
4-CF.sub.3-Ph, CF.sub.3), (M-7937, Cl, F, F, 4-CF.sub.3-Ph, Br),
(M-7938, Cl, F, F, 4-CF.sub.3-Ph, CH.sub.3), (M-7939, Cl, F, F,
4-(Me).sub.2N-Ph, H), (M-7940, Cl, F, F, 4-(Me).sub.3N-Ph, Cl),
(M-7941, Cl, F, F, 4-(Me).sub.2N-Ph, F), (M-7942, Cl, F, F,
4-(Me).sub.2M-Ph, CF.sub.3), (M-7943, Cl, F, F, 4-(Me).sub.2N-Ph,
Br), (M-7944, Cl, F, F, 4-(Me).sub.2N-Ph, CH.sub.3), (M-7945, Cl,
F, F, 4-OH-Ph, H), (M-7946, Cl, F, F, 4-OH-Ph, Cl), (M-7947, Cl, F,
F, 4-OH-Ph, F), (M-7948, Cl, F, F, 4-OH-Ph, CF.sub.3), (M-7949, Cl,
F, F, 4-OH-Ph, Br), (M-7950, Cl, F, F, 4-OH-Ph, CH.sub.3), (M-7951,
Cl, F, F, 3,4-di-F-Ph, H), (M-7952, Cl, F, F, 3,4-di-F-Ph, Cl),
(M-7953, Cl, F, F, 3,4-di-F-Ph, F), (M-7954, Cl, F, F, 3,4-di-F-Ph,
CF.sub.3), (M-7955, Cl, F, F, 3,4-di-F-Ph, Br), (M-7956, Cl, F, F,
3,4-di-F-Ph, CH.sub.3), (M-7957, Cl, F, F, 4-COOH-Ph, H), (M-7958,
Cl, F, F, 4-COOH-Ph, Cl), (M-7959, Cl, F, F, 4-COOH-Ph, F),
(M-7960, Cl, F, F, 4-COOH-Ph, CF.sub.3), (M-7961, Cl, F, F,
4-COOH-Ph, Br), (M-7962, Cl, F, F, 4-COOH-Ph, CH.sub.3), (M-7963,
Cl, F, F, Bn, H), (M-7964, Cl, F, F, Bn, Cl), (M-7965, Cl, F, F,
Bn, F), (M-7966, Cl, F, F, Bn, CF.sub.3), (M-7967, Cl, F, F, Bn,
Br), (M-7968, Cl, F, F, Bn, CH.sub.3), (M-7969, Cl, F, F, 4-F-Bn,
H), (M-7970, Cl, F, F, 4-F-Bn, Cl), (M-7971, Cl, F, F, 4-F-Bn, F),
(M-7972, Cl, F, F, 4-F-Bn, CF.sub.3), (M-7973, Cl, F, F, 4-F-Bn,
Br), (M-7974, Cl, F, F, 4-F-Bn, CH.sub.3), (M-7975, Cl, F, F, 2-Py,
H), (M-7976, Cl, F, F, 2-Py, Cl), (M-7977, Cl, F, F, 2-Py, F),
(M-7978, Cl, F, F, 2-Py, CF.sub.3), (M-7979, Cl, F, F, 2-Py, Br),
(M-7980, Cl, F, F, 2-Py, CH.sub.3), (M-7981, Cl, F, F, 3-Py, H),
(M-7982, Cl, F, F, 3-Py, Cl), (M-7983, Cl, F, F, 3-Py, F), (M-7984,
Cl, F, F, 3-Py, CF.sub.3), (M-7985, Cl, F, F, 3-Py, Br), (M-7986,
Cl, F, F, 3-Py, CH.sub.3), (M-7987, Cl, F, F, 4-Py, H), (M-7988,
Cl, F, F, 4-Py, Cl), (M-7989, Cl, F, F, 4-Py, F), (M-7990, Cl, F,
F, 4-Py, CF.sub.3), (M-7991, Cl, F, F, 4-Py, Br), (M-7992, Cl, F,
F, 4-Py, CH.sub.3), (M-7993, Cl, F, F, 2-th, H), (M-7994, Cl, F, F,
2-Th, Cl), (M-7995, Cl, F, F, 2-Th, F), (M-7996, Cl, F, F, 2-Th,
CF.sub.3), (M-7997, Cl, F, F, 2-Th, Br), (M-7998, Cl, F, F, 2-Th,
CH.sub.3), (M-7999, Cl, F, F, 3-Th, H), (M-8000, Cl, F, F, 3-Th,
Cl), (M-8001, Cl, F, F, 3-Th, F), (M-8002, Cl, F, F, 3-Th,
CF.sub.3), (M-8003, Cl, F, F, 3-Th, Br), (M-8004, Cl, F, F, 3-Th,
CH.sub.3), (M-8005, Cl, F, F, pyrrazol-2-yl, H), (M-8006, Cl, F, F,
pyrrazol-2-yl, Cl), (M-8007, Cl, F, F, pyrrazol-2-yl, F), (M-8008,
Cl, F, F, pyrrazol-2-yl, CF.sub.3), (M-8009, Cl, F, F,
pyrrazol-2-yl, Br), (M-8010, Cl, F, E, pyrrazol-2-yl, CH.sub.3),
(M-8011, Cl, F, F, pyrrazol-3-yl, H), (M-8012, Cl, F, F,
pyrrazol-3-yl, Cl), (M-8013, Cl, F, F, pyrrazol-3-yl, F), (M-8014,
Cl, F, F, pyrrazol-3-yl, CF.sub.3), (M-8015, Cl, F, F,
pyrrazol-3-yl, Br), (M-8016, Cl, F, F, pyrrazol-3-yl, CH.sub.3),
(M-8017, Cl, F, F, pyrimidin-2-yl, H), (M-8018, Cl, F, F,
pyrimidin-2-yl, Cl), (M-8019, Cl, F, F, pyrimidin-2-yl, F),
(M-8020, Cl, F, F, pyrimidin-2-yl, CF.sub.3), (M-8021, Cl, F, F,
pyrimidin-2-yl, Br), (M-8022, Cl, F, F, pyrimidin-2-yl, CH.sub.3),
(M-8023, Cl, F, F, pyrimidin-4-yl, H), (M-8024, Cl, F, F,
pyrimidin-4-yl, Cl), (M-8025, Cl, F, F, pyrimidin-4-yl, F),
(M-8026, Cl, F, F, pyrimidin-4-yl, CF.sub.3), (M-8027, Cl, F, F,
pyrimidin-4-yl, Br), (M-8028, Cl, F, F, pyrimidin-4-yl, CH.sub.3),
(M-8029, Cl, F, F, pyrimidin-5-yl, H), (M-8030, Cl, F, F,
pyrimidin-5-yl, Cl), (M-8031, Cl, F, F, pyrimidin-5-yl, F),
(M-8032, Cl, F, F, pyrimidin-5-yl, CF.sub.3), (M-8033, Cl, F, F,
pyrimidin-5-yl, Br), (M-8034, Cl, F, F, pyrimidin-5-yl, CH.sub.3),
(M-8035, Cl, F, F, HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-8036, Cl,
F, F, HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-8037, Cl, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-8038, Cl, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8039, Cl, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-8040, Cl, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-8041, Cl, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-8042, Cl, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-8043, Cl, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8044, Cl, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8045, Cl, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-8046, Cl, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-8047, Cl, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-8048, Cl, F,
F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-8049, Cl,
F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8050,
Cl, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-8051, Cl, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-8052, Cl, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-8053,
Cl, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
H), (M-8054, Cl, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-8055, Cl, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8056,
Cl, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-8057, Cl, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-8058, Cl, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-8059, Cl, F, F, MeOCH.sub.2, H), (M-8060, Cl, F, F, MeOCH.sub.2,
Cl), (M-8061, Cl, F, F, MeOCH.sub.2, F), (M-8062, Cl, F, F,
MeOCH.sub.2, CF.sub.3), (M-8063, Cl, F, F, MeOCH.sub.2, Br),
(M-8064, Cl, F, F, MeOCH.sub.2, CH.sub.3), (M-8065, Cl, F, F,
EtOCH.sub.2, H), (M-8066, Cl, F, F, EtOCH.sub.2, Cl), (M-8067, Cl,
F, F, EtOCH.sub.2, F), (M-8068, Cl, F, F, EtOCH.sub.2, CF.sub.3),
(M-8069, Cl, F, F, EtOCH.sub.2, Br), (M-8070, Cl, F, F,
EtOCH.sub.2, CH.sub.3), (M-8071, Cl, F, F, EtOCH.sub.2CH.sub.2, H),
(M-8072, Cl, F, F, EtOCH.sub.2CH.sub.2, Cl), (M-8073, Cl, F, F,
EtOCH.sub.2CH.sub.2, F), (M-8074, Cl, F, F, EtOCH.sub.2CH.sub.2,
CF.sub.3), (M-8075, Cl, F, F, EtOCH.sub.2CH.sub.2, Br), (M-8076,
Cl, F, F, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-8077, Cl, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-8078, Cl, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-8079, Cl, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-8080, Cl, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-8081, Cl, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-8082, Cl, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-8083, Cl, F, F,
MeOCH.sub.2CH.sub.2, H), (M-8084, Cl, F, F, MeOCH.sub.2CH.sub.2,
Cl), (M-8085, Cl, F, F, MeOCH.sub.2CH.sub.2, F), (M-8086, Cl, F, F,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-8087, Cl, F, F,
MeOCH.sub.2CH.sub.2, Br), (M-8088, Cl, F, F, MeOCH.sub.2CH.sub.2,
CH.sub.3), (M-8089, Cl, F, F, HOCH.sub.2, H), (M-8090, Cl, F, F,
HOCH.sub.2, Cl), (M-8091, Cl, F, F, HOCH.sub.2, F), (M-8092, Cl, F,
F, HOCH.sub.2, CF.sub.3), (M-8093, Cl, F, F, HOCH.sub.2, Br),
(M-8094, Cl, F, F, HOCH.sub.2, CH.sub.3), (M-8095, Cl, F, F,
HOCH.sub.2CH.sub.2, H), (M-8096, Cl, F, F, HOCH.sub.2CH.sub.2, Cl),
(M-8097, Cl, F, F, HOCH.sub.2CH.sub.2, F), (M-8098, Cl, F, F,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-8099, Cl, F, F,
HOCH.sub.2CH.sub.2, Br), (M-8100, Cl, F, F, HOCH.sub.2CH.sub.2,
CH.sub.3), (M-8101, Cl, F, F, HOCH.sub.2CH.sub.2CH.sub.2, H),
(M-8102, Cl, F, F, HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-8103, Cl, F,
F, HOCH.sub.2CH.sub.2CH.sub.2, F), (M-8104, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8105, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-8106, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-8107, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-8108, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-8109, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8110, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8111, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-8112, Cl, F, F,
HOCH
.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-8113, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-8114, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-8115, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8116, Cl, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8117, Cl,
F, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-8118, Cl,
F, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-8119, Cl, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H),
(M-8120, Cl, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-8121, Cl, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-8122, Cl, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-8123, Cl, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-8124, Cl, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-8125, Cl, F, F, (Me).sub.2N, H), (M-8126, Cl, F, F, (Me).sub.2N,
Cl), (M-8127, Cl, F, F, (Me).sub.2N, F), (M-8128, Cl, F, F,
(Me).sub.2N, CF.sub.3), (M-8129, Cl, F, F, (Me).sub.2N, Br),
(M-8130, Cl, F, F, (Me).sub.2N, CH.sub.3), (M-8131, Cl, F, F,
piperidin-4-yl-methyl, H), (M-8132, Cl, F, F,
piperidin-4-yl-methyl, Cl), (M-8133, Cl, F, F,
piperidin-4-yl-methyl, F), (M-8134, Cl, F, F,
piperidin-4-yl-methyl, CF.sub.3), (M-8185, Cl, F, F,
piperidin-4-yl-methyl, Br), (M-8136, Cl, F, F,
piperidin-4-yl-methyl, CH.sub.3), (M-8137, Cl, F, F,
cyclohexylmethyl, H), (M-8138, Cl, F, F, cyclohexylmethyl, Cl),
(M-8139, Cl, F, F, cyclohexylmethyl, F), (M-8140, Cl, F, F,
cyclohexylmethyl, CF.sub.3), (M-8141, Cl, F, F, cyclohexylmethyl,
Br), (M-8142, Cl, F, F, cyclohexylmethyl, CH.sub.3), (M-8143, Cl,
F, Cl, H, H), (M-8144, Cl, F, Cl, H, Cl), (M-8145, Cl, F, Cl, H,
F), (M-8146, Cl, F, Cl, H, CF.sub.3), (M-8147, Cl, F, Cl, H, Br),
(M-8148, Cl, F, Cl, H, CH.sub.3), (M-8149, Cl, F, Cl, F, H),
(M-8150, Cl, F, Cl, F, Cl), (M-8151, Cl, F, Cl, F, F), (M-8152, Cl,
F, Cl, F, CF.sub.3), (M-8153, Cl, F, Cl, F, Br), (M-8154, Cl, F,
Cl, F, CH.sub.3), (M-8155, Cl, F, Cl, Cl, H), (M-8156, Cl, F, Cl,
Cl, Cl), (M-8157, Cl, F, Cl, Cl, F), (M-8158, Cl, F, CU Cl,
CF.sub.3), (M-8159, Cl, F, Cl, Cl, Br), (M-8160, Cl, F, Cl, Cl,
CH.sub.3), (M-8161, Cl, F, Cl, CH.sub.3, H), (M-8162, Cl, F, Cl,
CH.sub.3, Cl), (M-8163, Cl, F, Cl, CH.sub.3, F), (M-8164, Cl, F,
Cl, CH.sub.3, CF.sub.3), (M-8165, Cl, F, Cl, CH.sub.3, Br),
(M-8166, Cl, F, Cl, CH.sub.3, CH.sub.3), (M-8167, Cl, F, Cl, Et,
H), (M-8168, Cl, F, Cl, Et, Cl), (M-8169, Cl, F, Cl, Et, F),
(M-8170, Cl, F, Cl, Et, CF.sub.3), (M-8171, Cl, F, Cl, Et, Br),
(M-8172, Cl, F, Cl, Et, CH.sub.3), (M-8173, Cl, F, Cl, n-Pr, H),
(M-8174, Cl, F, Cl, n-Pr, Cl), (M-8175, Cl, F, Cl, n-Pr, F),
(M-8176, Cl, F, Cl, n-Pr, CF.sub.3), (M-8177, Cl, F, Cl, n-Pr, Br),
(M-8178, Cl, F, Cl, n-Pr, CH.sub.3), (M-8179, Cl, F, Cl, c-Pr, H),
(M-8180, Cl, F, Cl, c-Pr, Pr, Cl), (M-8181, Cl, F, Cl, c-Pr, F),
(M-8182, Cl, F, Cl, c-Pr, CF.sub.3), (M-8183, Cl, F, Cl, c-Pr, Br),
(M-8184, Cl, F, Cl, c-Pr, CH.sub.3), (M-8185, Cl, F, Cl, i-Pr, H),
(M-8186, Cl, F, Cl, i-Pr, Cl), (M-8187, Cl, F, Cl, i-Pr, F),
(M-8188, Cl, F, Cl, i-Pr, CF.sub.3), (M-8189, Cl, F, Cl, i-Pr, Br),
(M-8190, Cl, F, Cl, i-Pr, CH.sub.3), (M-8191, Cl, F, Cl, n-Bu, H),
(M-8192, Cl, F, Cl, n-Bu, Cl), (M-8193, Cl, F, Cl, n-Bu, F),
(M-8194, Cl, F, Cl, n-Bu, CF.sub.3), (M-8195, Cl, F, Cl, n-Bu, Br),
(M-8196, Cl, F, Cl, n-Bu, CH.sub.3), (M-8197, Cl, F, Cl, i-Bu, H),
(M-8198, Cl, F, Cl, i-Bu, Cl), (M-8199, Cl, F, Cl, i-Bu, F),
(M-8200, Cl, F, Cl, i-Bu, CF.sub.3), (M-8201, Cl, F, Cl, i-Bu, Br),
(M-8202, Cl, F, Cl, i-Bu, CH.sub.3), (M-8203, Cl, F, Cl, sec-Bu,
H), (M-8204, Cl, F, Cl, sec-Bu, Cl), (M-8205, Cl, F, Cl, sec-Bu,
F), (M-8206, Cl, F, Cl, sec-Bu, CF.sub.3), (M-8207, Cl, F, Cl,
sec-Bu, Br), (M-8208, Cl, F, Cl, sec-Bu, CH.sub.3), (M-8209, Cl, F,
Cl, n-Pen, H), (M-8210, Cl, F, Cl, n-Pen, Cl), (M-8211, Cl, F, Cl,
n-Pen, F), (M-8212, Cl, F, Cl, n-Pen, CF.sub.3), (M-8213, Cl, F,
Cl, n-Pen, Br), (M-8214, Cl, F, Cl, n-Pen, CH.sub.3), (M-8215, Cl,
F, Cl, c-Pen, H), (M-8216, Cl, F, Cl, c-Pen, Cl), (M-8217, Cl, F,
Cl, c-Pen, F), (M-8218, Cl, F, Cl, c-Pen, CF.sub.3), (M-8219, Cl,
F, Cl, c-Pen, Br), (M-8220, Cl, F, Cl, c-Pen, CH.sub.3), (M-8221,
Cl, F, Cl, n-Hex, H), (M-8222, Cl, F, Cl, n-Hex, Cl), (M-8223, Cl,
F, Cl, n-Hex, F), (M-8224, Cl, F, Cl, n-Hex, CF.sub.3), (M-8225,
Cl, F, Cl, n-Hex, Br), (M-8226, Cl, F, Cl, n-Hex, CH.sub.3),
(M-8227, Cl, F, Cl, c-Hex, H), (M-8228, Cl, F, Cl, c-Hex, Cl),
(M-8229, Cl, F, Cl, c-Hex, F), (M-8230, Cl, F, Cl, c-Hex,
CF.sub.3), (M-8231, Cl, F, Cl, c-Hex, Br), (M-8232, Cl, F, Cl,
c-Hex, CH.sub.3), (M-8233, Cl, F, Cl, OH, H), (M-8234, Cl, F, Cl,
OH, Cl), (M-8235, Cl, F, Cl, OH, F), (M-8236, Cl, F, Cl, OH,
CF.sub.3), (M-8237, Cl, F, Cl, OH, Br), (M-8238, Cl, F, Cl, OH,
CH.sub.3), (M-8239, Cl, F, Cl, EtO, H), (M-8240, Cl, F, Cl, EtO,
Cl), (M-8241, Cl, F, Cl, EtO, F), (M-8242, Cl, F, Cl, EtO,
CF.sub.3), (M-8243, Cl, F, Cl, EtO, Br), (M-8244, Cl, F, Cl, EtO,
CH.sub.3), (M-8245, Cl, F, Cl, n-PrO, H), (M-8246, Cl, F, Cl,
n-PrO, Cl), (M-8247, Cl, F, Cl, n-PrO, F), (M-8248, Cl, F, Cl,
n-PrO, CF.sub.3), (M-8249, Cl, F, Cl, n-PrO, Br), (M-8250, Cl, F,
Cl, n-PrO, CH.sub.3), (M-8251, Cl, F, Cl, PhO, H), (M-8252, Cl, F,
Cl, PhO, Cl), (M-8253, Cl, F, Cl, PhO, F), (M-8254, Cl, F, Cl, PhO,
CF.sub.3), (M-8255, Cl, F, Cl, PhO, Br), (M-8256, Cl, F, Cl, PhO,
CH.sub.3), (M-8257, Cl, F, Cl, BuO, H), (M-8258, Cl, F, Cl, BnO,
Cl), (M-8259, Cl, F, Cl, BnO, F), (M-8260, Cl, F, Cl, BnO,
CF.sub.3), (M-8261, Cl, F, Cl, BnO, Br), (M-8262, Cl, F, Cl, BnO,
CH.sub.3), (M-8263, Cl, F, Cl, PhCH.sub.2CH.sub.2O, H), (M-8264,
Cl, F, Cl, PhCH.sub.2CH.sub.2O, Cl), (M-8265, Cl, F, Cl,
PhCH.sub.2CH.sub.2O, F), (M-8266, Cl, F, Cl, PhCH.sub.2CH.sub.2O,
CF.sub.3), (M-8267, Cl, F, Cl, PhCH.sub.2CH.sub.2O, Br), (M-8268,
Cl, F, Cl, PhCH.sub.2CH.sub.2O, CH.sub.3), (M-8269, Cl, F, Cl,
CF.sub.3O, H), (M-8270, Cl, F, Cl, CF.sub.3O, Cl), (M-8271, Cl, F,
Cl, CF.sub.3O, F), (M-8272, Cl, F, Cl, CF.sub.3O, CF.sub.3),
(M-8273, Cl, F, Cl, CF.sub.3O, Br), (M-8274, Cl, F, Cl, CF.sub.3O,
CH.sub.3), (M-8275, Cl, F, Cl, Ph, H), (M-8276, Cl, F, Cl, Ph, Cl),
(M-8277, Cl, F, Cl, Ph, F), (M-8278, Cl, F, Cl, Ph, CF.sub.3),
(M-8279, Cl, F, Cl, Ph, Br), (M-8280, Cl, F, Cl, Ph, CH.sub.3),
(M-8281, Cl, F, Cl, 4-F-Ph, H), (M-8282, Cl, F, Cl, 4-F-Ph, Cl),
(M-8283, Cl, F, Cl, 4-F-Ph, F), (M-8284, Cl, F, Cl, 4-F-Ph,
CH.sub.3), (M-8285, Cl, F, Cl, 4-F-Ph, Br), (M-8286, Cl, F, Cl,
4-F-Ph, CH.sub.3), (M-8287, Cl, F, Cl, 4-CF.sub.3-Ph, H), (M-8288,
Cl, F, Cl, 4-CF.sub.3-Ph, Cl), (M-8289, Cl, F, Cl, 4-CF.sub.3-Ph,
F), (M-8290, Cl, F, Cl, 4-CF.sub.3-Ph, CF.sub.3), (M-8291, Cl, F,
Cl, 4-CF.sub.3-Ph, Br), (M-8292, Cl, F, Cl, 4-CF.sub.3-Ph,
CH.sub.3), (M-8293, Cl, F, Cl, 4-(Me).sub.2N-Ph, H), (M-8294, Cl,
F, Cl, 4-(Me).sub.2N-Ph, Cl), (M-8295, Cl, F, Cl, 4-(Me).sub.2N-Ph,
F), (M-8296, Cl, F, Cl, 4-(Me).sub.2N-Ph, CF.sub.3), (M-8297, Cl,
F, Cl, 4-(Me).sub.2N-Ph, Br), (M-8298, Cl, F, Cl, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-8299, Cl, F, Cl, 4-OH-Ph, H), (M-8300, Cl, F, Cl,
4-OH-Ph, Cl), (M-8301, Cl, F, Cl, 4-OH-Ph, F), (M-8302, Cl, F, Cl,
4-OH-Ph, CF.sub.3), (M-8303, Cl, F, Cl, 4-OH-Ph, Br), (M-8304, Cl,
F, Cl, 4-OH-Ph, CH.sub.3), (M-8305, Cl, F, Cl, 3,4-di-F-Ph, H),
(M-8306, Cl, F, Cl, 3,4-di-F-Ph, Cl), (M-8307, Cl, F, Cl,
3,4-di-F-Ph, F), (M-8308, Cl, F, Cl, 3,4-di-F-Ph, CF.sub.3),
(M-8309, Cl, F, Cl, 3,4-di-F-Ph, Br), (M-8310, Cl, F, Cl,
3,4-di-F-Ph, CH.sub.3), (M-8311, Cl, F, Cl, 4-COOH-Ph, H), (M-8312,
Cl, F, Cl, 4-COOH-Ph, Cl), (M-8313, Cl, F, Cl, 4-COOH-Ph, F),
(M-8314, Cl, F, Cl, 4-COOH-Ph, CF.sub.3), (M-8315, Cl, F, Cl,
4-COOH-Ph, Br), (M-8316, Cl, F, Cl, 4-COOH-Ph, CH.sub.3), (M-8317,
C), F, Cl, Bn, H), (M-8318, Cl, F, Cl, Bn, Cl), (M-8319, Cl, F, Cl,
Bn, F), (M-8320, Cl, F, Cl, Bn, CF.sub.3), (M-8321, Cl, F, Cl, Bn,
Br), (M-8322, Cl, F, Cl, Bn, CH.sub.3), (M-8323, Cl, F, Cl, 4-F-Bu,
H), (M-8324, Cl, F, Cl, 4-F-Bn, Cl), (M-8325, Cl, F, Cl, 4-F-Bn,
F), (M-8326, Cl, F, Cl, 4-F-Bn, CF.sub.3), (M-8327, Cl, F, Cl,
4-F-Bn, Br), (M-8328, Cl, F, Cl, 4-F-Bn, CH.sub.3), (M-8329, Cl, F,
Cl, 2-Py, H), (M-8330, Cl, F, Cl, 2-Py, Cl), (M-8331, Cl, F, Cl,
2-Py, F), (M-8332, Cl, F, Cl, 2-Py, CF.sub.3), (M-8333, Cl, F, Cl,
2-Py, Br), (M-8334, Cl, F, Cl, 2-Py, CH.sub.3), (M-8335, Cl, F, Cl,
3-Py, H), (M-8336, Cl, F, Cl, 3-Py, Cl), (M-8337, Cl, F, Cl, 3-Py,
F), (M-8338, Cl, F, Cl, 3-Py, CF.sub.3), (M-8339, Cl, F, Cl, 3-Py,
Br), (M-8340, Cl, F, Cl, 3-Py, CH.sub.3), (M-8341, Cl, F, Cl, 4-Py,
H), (M-8342, Cl, F, Cl, 4-Py, Cl), (M-8343, Cl, F, Cl, 4-Py, F),
(M-8344, Cl, F, Cl, 4-Py, CF.sub.3), (M-8345, Cl, F, Cl, 4-Py, Br),
(M-8346, Cl, F, Cl, 4-Py, CH.sub.3), (M-8347, Cl, F, Cl, 2-Th, H),
(M-8348, Cl, F, Cl, 2-Th, Cl), (M-8349, Cl, F, Cl, 2-Th, F),
(M-8350, Cl, F, Cl, 2-th, CF.sub.3), (M-8351, Cl, F, Cl, 2-Th, Br),
(M-8352, Cl, F, Cl, 2-Th, CH.sub.3), (M-8353, Cl, F, Cl, 3-Th, H),
(M-8354, Cl, F, Cl, 3-Th, Cl), (M-8355, Cl, F, Cl, 3-Th, F),
(M-8356, Cl, F, Cl, 3-Th, CF.sub.3), (M-8357, Cl, F, Cl, 3-Th, Br),
(M-8358, Cl, F, Cl, 3-Th, CH.sub.3), (M-8359, Cl, F, Cl,
pyrrazol-2-yl, H), (M-8360, Cl, F, Cl, pyrrazol-2-yl, Cl), (M-8361,
Cl, F, Cl, pyrrazol-2-yl, F), (M-8362, Cl, F, Cl, pyrrazol-2-yl,
CF.sub.3), (M-8363, Cl, F, Cl, pyrrazol-2-yl, Br), (M-8364, Cl, F,
Cl, pyrrazol-2-yl, CH.sub.3), (M-8365, Cl, F, Cl, pyrrazol-3-yl,
H), (M-8366, Cl, F, Cl, pyrrazol-3-yl, Cl), (M-8367, Cl, F, Cl,
pyrrazol-3-yl, F), (M-8368, Cl, F, Cl, pyrrazol-3-yl, CF.sub.3),
(M-8369, Cl, F, Cl, pyrrazol-3-yl, Br), (M-8370, Cl, F, Cl,
pyrrazol-3-yl, CH.sub.3), (M-8371, Cl, F, Cl, pyrimidin-2-yl, H),
(M-8372, Cl, F, Cl, pyrimidin-2-yl, Cl), (M-8373, Cl, F, Cl,
pyrimidin-2-yl, F), (M-8374, Cl, F, Cl, pyrimidin-2-yl, CF.sub.3),
(M-8375, Cl, F, Cl, pyrimidin-2-yl, Br), (M-8376, Cl, F, Cl,
pyrimidin-2-yl, CH.sub.3), (M-8377, Cl, F, Cl, pyrimidin-4-yl, H),
(M-8378, Cl, F, Cl, pyrimidin-4-yl, Cl), (M-8379, Cl, F, Cl,
pyrimidin-4-yl, F), (M-8380, Cl, F, Cl, pyrimidin-4-yl, CF.sub.3),
(M-8381, Cl, F, Cl, pyrimidin-4-yl, Br), (M-8382, Cl, F, Cl,
pyrimidin-4-yl, CH.sub.3), (M-8383, Cl, F, Cl, pyrimidin-5-yl, H),
(M-8384, Cl, F, Cl, pyrimidin-5-yl, Cl), (M-8385, Cl, F, Cl,
pyrimidin-5-yl, F), (M-8386, Cl, F, Cl, pyrimidin-5-yl, CF.sub.3),
(M-8387, Cl, F, Cl, pyrimidin-5-yl, Br), (M-8388, Cl, F, Cl,
pyrimidin-5-yl, CH.sub.3), (M-8389, Cl, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-8390, Cl, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-8391, Cl, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-8392, Cl, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8393, Cl, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2Br), (M-8394, Cl, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-8395, Cl, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-8396, Cl, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-8397, Cl, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8398, Cl, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8399, Cl, F,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-8400, Cl, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-8401, Cl, F,
Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-8402, Cl,
F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-8403,
Cl, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-8404, Cl, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-8405, Cl, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-8406, Cl, F,
Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-8407, Cl, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-8408,
Cl, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-8409,
Cl, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
F), (M-8410, Cl, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-8411, Cl, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-8412, Cl, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-8413, Cl, F, Cl, MeOCH.sub.2, H), (M-8414, Cl, F, Cl,
MeOCH.sub.2, Cl), (M-8415, Cl, F, Cl, MeOCH.sub.2, F), (M-8416, Cl,
F, Cl, MeOCH.sub.2, CF.sub.3), (M-8417, Cl, F, Cl, MeOCH.sub.2,
Br), (M-8418, Cl, F, Cl, MeOCH.sub.2, CH.sub.3), (M-8419, Cl, F,
Cl, EtOCH.sub.2, H), (M-8420, Cl, F, Cl, EtOCH.sub.2, Cl), (M-8421,
Cl, F, Cl, EtOCH.sub.2, F), (M-8422, Cl, F, Cl, EtOCH.sub.2,
CF.sub.3), (M-8423, Cl, F, Cl, EtOCH.sub.2, Br), (M-8424, Cl, F,
Cl, EtOCH.sub.2, CH.sub.3), (M-8425, Cl, F, Cl,
EtOCH.sub.2CH.sub.2, H), (M-8426, Cl, F, Cl, EtOCH.sub.2CH.sub.2,
Cl), (M-8427, Cl, F, Cl, EtOCH.sub.2CH.sub.2, F), (M-8428, Cl, F,
Cl, EtOCH.sub.2CH.sub.2, CF.sub.3), (M-8429, Cl, F, Cl,
EtOCH.sub.2CH.sub.2, Br), (M-8430, Cl, F, Cl, EtOCH.sub.2CH.sub.2,
CH.sub.3), (M-8431, Cl, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-8432, Cl, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-8433, Cl, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-8434, Cl, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-8435, Cl, F,
Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-8436, Cl, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-8437, Cl, F,
Cl, MeOCH.sub.2CH.sub.2, H), (M-8438, Cl, F, Cl,
MeOCH.sub.2CH.sub.2, Cl), (M-8439, Cl, F, Cl, MeOCH.sub.2CH.sub.2,
F), (M-8440, Cl, F, Cl, MeOCH.sub.2CH.sub.2, CF.sub.3), (M-8441,
Cl, F, Cl, MeOCH.sub.2CH.sub.2, Br), (M-8442, Cl, F, Cl,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-8443, Cl, F, Cl, HOCH.sub.2, H),
(M-8444, Cl, F, Cl, HOCH.sub.2, Cl), (M-8445, Cl, F, Cl,
HOCH.sub.2, F), (M-8446, Cl, F, Cl, HOCH.sub.2, CF.sub.3), (M-8447,
Cl, F, Cl, HOCH.sub.2, Br), (M-8448, Cl, F, Cl, HOCH.sub.2,
CH.sub.3), (M-8449, Cl, F, Cl, HOCH.sub.2CH.sub.2H), (M-8450, Cl,
F, Cl, HOCH.sub.2CH.sub.2, Cl), (M-8451, Cl, F, Cl,
HOCH.sub.2CH.sub.2, F), (M-8452, Cl, F, Cl, HOCH.sub.2CH.sub.2,
CF.sub.3), (M-8453, Cl, F, Cl, HOCH.sub.2CH.sub.2, Br), (M-8454,
Cl, F, Cl, HOCH.sub.2CH.sub.2, CH.sub.3), (M-8455, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-8456, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-8457, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-8458, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8459, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-8460, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-8461, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-8462, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-8463, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8464, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8465, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-8466, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-8467, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-8468, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-8469, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8470, Cl, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-8471, Cl,
F, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-8472, Cl,
F, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3),
(M-8473, Cl, F, Cl, HOCH
.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-8474, Cl, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-8475, Cl, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-8476, Cl, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-8477, Cl, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-8478, Cl, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.1CH.sub.2, CH.sub.3), (M-8479, Cl, F, Cl,
(Me).sub.2N, H), (M-8480, Cl, F, Cl, (Me).sub.2N, Cl), (M-8481, Cl,
F, Cl, (Me).sub.2N, F), (M-8482, Cl, F, Cl, (Me).sub.2N, CF.sub.3),
(M-8483, Cl, F, Cl, (Me).sub.2N, Br), (M-8484, Cl, F, Cl,
(Me).sub.2N, CH.sub.3), (M-8485, Cl, F, Cl, piperidin-4-yl-methyl,
H), (M-8486, Cl, F, Cl, piperidin-4-yl-methyl, Cl), (M-8487, Cl, F,
Cl, piperidin-4-yl-methyl, F), (M-8488, Cl, F, Cl,
piperidin-4-yl-methyl, CF.sub.3), (M-8489, Cl, F, Cl,
piperidin-4-yl-methyl, Br), (M-8490, Cl, F, Cl,
piperidin-4-yl-methyl, CH.sub.3), (M-8491, Cl, F, Cl,
cyclohexylmethyl, H), (M-8492, Cl, F, Cl, cyclohexylmethyl, Cl),
(M-8493, Cl, F, Cl, cyclohexylmethyl, F), (M-8494, Cl, F, Cl,
cyclohexylmethyl, CF.sub.3), (M-8495, Cl, F, Cl, cyclohexylmethyl,
Br), (M-8496, Cl, F, Cl, cyclohexylmethyl, CH.sub.3), (M-8497, Cl,
CH.sub.3, H, H, H), (M-8498, Cl, CH.sub.3, H, H, Cl), (M-8499, Cl,
CH.sub.3, H, H, F), (M-8500, Cl, CH.sub.3, H, H, CF.sub.3),
(M-8501, Cl, CH.sub.3, H, H, Br), (M-8502, Cl, CH.sub.3, H, H,
CH.sub.3), (M-8503, Cl, CH.sub.3, H, F, H), (M-8504, Cl, CH.sub.3,
H, F, Cl), (M-8505, Cl, CH.sub.3, H, F, F), (M-8506, Cl, CH.sub.3,
H, F, CF.sub.3), (M-8507, Cl, CH.sub.3, H, F, Br), (M-8508, Cl,
CH.sub.3, H, F, CH.sub.3), (M-8509, Cl, CH.sub.3, H, Cl, H),
(M-8510, Cl, CH.sub.3, H, Cl, Cl), (M-8511, Cl, CH.sub.3, H, Cl,
F), (M-8512, Cl, CH.sub.3, H, Cl, CF.sub.3), (M-8513, Cl, CH.sub.3,
H, Cl, Br), (M-8514, Cl, CH.sub.3, H, Cl, CH.sub.3), (M-8515, Cl,
CH.sub.3, H, CH.sub.3, H), (M-8516, Cl, CH.sub.3, H, CH.sub.3, Cl),
(M-8517, Cl, CH.sub.3, H, CH.sub.3, F), (M-8518, Cl, CH.sub.3, H,
CH.sub.3, CF.sub.3), (M-8519, Cl, CH.sub.3, H, CH.sub.3, Br),
(M-8520, Cl, CH.sub.3, H, CH.sub.3, CH.sub.3), (M-8521, Cl,
CH.sub.3, H, Et, H), (M-8522, Cl, CH.sub.3, H, Et, Cl), (M-8523,
Cl, CH.sub.3, H, Et, F), (M-8524, Cl, CH.sub.3, H, Et, CF.sub.3),
(M-8525, Cl, CH.sub.3, H, Et, Br), (M-8526, Cl, CH.sub.3, H, Et,
CH.sub.3), (M-8527, Cl, CH.sub.3, H, n-Pr, H), (M-8528, Cl,
CH.sub.3, H, n-Pr, Cl), (M-8529, Cl, CH.sub.3, H, n-Pr, F),
(M-8530, Cl, CH.sub.3, H, n-Pr, CF.sub.3), (M-8531, Cl, CH.sub.3,
H, n-Pr, Br), (M-8532, Cl, CH.sub.3, H, n-Pr, CH.sub.3), (M-8533,
Cl, CH.sub.3, H, c-Pr, H), (M-8534, Cl, CH.sub.3, H, c-Pr, Cl),
(M-8535, Cl, CH.sub.3, H, c-Pr, F), (M-8536, Cl, CH.sub.3, H, c-Pr,
CF.sub.3), (M-8537, Cl, CH.sub.3, H, c-Pr, Br), (M-8538, Cl,
CH.sub.3, H, c-Pr, CH.sub.3), (M-8539, Cl, CH.sub.3, H, i-Pr, H),
(M-8540, Cl, CH.sub.3, H, i-Pr, Cl), (M-8541, Cl, CH.sub.3, H,
i-Pr, F), (M-8542, Cl, CH.sub.3, H, i-Pr, CF.sub.3), (M-8543, Cl,
CH.sub.3, H, i-Pr, Br), (M-8544, Cl, CH.sub.3, H, i-Pr, CH.sub.3),
(M-8545, Cl, CH.sub.3, H, n-Bu, H), (M-8546, Cl, CH.sub.3, H, n-Bu,
Cl), (M-8547, Cl, CH.sub.3, H, n-Bu, F), (M-8548, Cl, CH.sub.3, H,
n-Bu, CF.sub.3), (M-8549, Cl, CH.sub.3, H, n-Bu, Br), (M-8550, Cl,
CH.sub.3, H, n-Bu, CH.sub.3), (M-8551, Cl, CH.sub.3, H, i-Bu, H),
(M-8552, Cl, CH.sub.3, H, i-Bu, Cl), (M-8553, Cl, CH.sub.3, H,
i-Bu, F), (M-8554, Cl, CH.sub.3, H, i-Bu, CF.sub.3), (M-8555, Cl,
CH.sub.3, H, i-Bu, Br), (M-8556, Cl, CH.sub.3, H, i-Bu, CH.sub.3),
(M-8557, Cl, CH.sub.3, H, sec-Bu, H), (M-8558, Cl, CH.sub.3, H,
sec-Bu, Cl), (M-8559, Cl, CH.sub.3, H, sec-Bu, F), (M-8560, Cl,
CH.sub.3, H, sec-Bu, CF.sub.3), (M-8561, Cl, CH.sub.3, H, sec-Bu,
Br), (M-8562, Cl, CH.sub.3, H, sec-Bu, CH.sub.3), (M-8563, Cl,
CH.sub.3, H, n-Pen, H), (M-8564, Cl, CH.sub.3, H, n-Pen, Cl),
(M-8565, Cl, CH.sub.3, H, n-Pen, F), (M-8566, Cl, CH.sub.3, H,
n-Pen, CF.sub.3), (M-8567, Cl, CH.sub.3, H, n-Pen, Br), (M-8568,
Cl, CH.sub.3, H, n-Pen, CH.sub.3), (M-8569, Cl, CH.sub.3, H, c-Pen,
H), (M-8570, Cl, CH.sub.3, H, c-Pen, Cl), (M-8571, Cl, CH.sub.3, H,
c-Pen, F), (M-8572, Cl, CH.sub.3, H, c-Pen, CF.sub.3), (M-8573, Cl,
CH.sub.3, H, c-Pen, Br), (M-8574, Cl, CH.sub.3, H, c-Pen,
CH.sub.3), (M-8575, Cl, CH.sub.3, H, n-Hex, H), (M-8576, Cl,
CH.sub.3, H, n-Hex, Cl), (M-8577, Cl, CH.sub.3, H, n-Hex, F),
(M-8578, Cl, CH.sub.3, H, n-Hex, CF.sub.3), (M-8579, Cl, CH.sub.3,
H, n-Hex, Br), (M-8580, Cl, CH.sub.3, H, n-Hex, CH.sub.3), (M-8581,
Cl, CH.sub.3, H, c-Hex, H), (M-8582, Cl, CH.sub.3, H, c-Hex, Cl),
(M-8583, Cl, CH.sub.3, H, c-Hex, F), (M-8584, Cl, CH.sub.3, H,
c-Hex, CF.sub.3), (M-8585, Cl, CH.sub.3, H, c-Hex, Br), (M-8586,
Cl, CH.sub.3, H, c-Hex, CH.sub.3), (M-8587, Cl, CH.sub.3, H, OH,
H), (M-8588, Cl, CH.sub.3, H, OH, Cl), (M-8589, Cl, CH.sub.3, H,
OH, F), (M-8590, Cl, CH.sub.3, H, OH, CF.sub.3), (M-8591, Cl,
CH.sub.3, H, OH, Br), (M-8592, Cl, CH.sub.3, H, OH, CH.sub.3),
(M-8593, Cl, CH.sub.3, H, EtO, H), (M-8594, Cl, CH.sub.3, H, EtO,
Cl), (M-8595, Cl, CH.sub.3, H, EtO, F), (M-8596, Cl, CH.sub.3, H,
EtO, CF.sub.3), (M-8597, Cl, CH.sub.3, H, EtO, Br), (M-8598, Cl,
CH.sub.3, H, EtO, CH.sub.3), (M-8599, Cl, CH.sub.3, H, n-PrO, H),
(M-8600, Cl, CH.sub.3, H, n-PrO, Cl), (M-8601, Cl, CH.sub.3, H,
n-PrO, P), (M-8602, Cl, CH.sub.3, H, n-PrO, CF.sub.3), (M-8603, Cl,
CH.sub.3, H, n-PrO, Br), (M-8604, CL, CH.sub.3, H, n-PrO,
CH.sub.3), (M-8605, Cl, CH.sub.3, H, PhO, H), (M-8606, Cl,
CH.sub.3, H, PhO, Cl), (M-8607, Cl, CH.sub.3, H, PhO, F), (M-8608,
Cl, CH.sub.3, H, PhO, CF.sub.3), (M-8609, Cl, CH.sub.3, H, PhO,
Br), (M-8610, Cl, CH.sub.3, H, PhO, CH.sub.3), (M-8611, Cl,
CH.sub.3, H, BnO, H), (M-8612, Cl, CH.sub.3, H, BnO, Cl), (M-8613,
Cl, CH.sub.3, H, BnO, F), (M-8614, Cl, CH.sub.3, H, BnO, CF.sub.3),
(M-8615, Cl, CH.sub.3, H, BnO, Br), (M-8616, Cl, CH.sub.3, H, BnO,
CH.sub.3), (M-8617, Cl, CH.sub.3, H, PhCH.sub.2CH.sub.2O, H),
(M-8618, Cl, CH.sub.3, H, PhCH.sub.2CH.sub.2O, Cl), (M-8619, Cl,
CH.sub.3, H, PhCH.sub.2CH.sub.2O, P), (M-8620, Cl, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-8621, Cl, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, Br), (M-8622, Cl, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-8623, Cl, CH.sub.3, H,
CF.sub.3O, H), (M-8624, Cl, CH.sub.3, H, CF.sub.3O, Cl), (M-8625,
Cl, CH.sub.3, H, CF.sub.3O, F), (M-8626, Cl, CH.sub.3, H,
CF.sub.3O, CF.sub.3), (M-8627, Cl, CH.sub.3, H, CF.sub.3O, Br),
(M-8628, Cl, CH.sub.3, H, CF.sub.3O, CH.sub.3), (M-8629, Cl,
CH.sub.3, H, Ph, H), (M-8630, Cl, CH.sub.3, H, Ph, Cl), (M-8631,
Cl, CH.sub.3, H, Ph, F), (M-8632, Cl, CH.sub.3, H, Ph, CF.sub.3),
(M-8633, Cl, CH.sub.3, H, Ph, Br), (M-8634, Cl, CH.sub.3, H, Ph,
CH.sub.3), (M-8635, Cl, CH.sub.3, H, 4-F-Ph, H), (M-8636, Cl,
CH.sub.3, H, 4-F-Ph, Cl), (M-8637, Cl, CH.sub.3, H, 4-F-Ph, F),
(M-8638, Cl, CH.sub.3, H, 4-F-Ph, CF.sub.3), (M-8639, Cl, CH.sub.3,
H, 4-F-Ph, Br), (M-8640, Cl, CH.sub.3, H, 4-F-Ph, CH.sub.3),
(M-8641, Cl, CH.sub.3, H, 4-CF.sub.3-Ph, H), (M-8642, Cl, CH.sub.3,
H, 4-CF.sub.3-Ph, Cl), (M-8643, Cl, CH.sub.3, H, 4-CF.sub.3-Ph, F),
(M-8644, Cl, CH.sub.3, H, 4-CF.sub.3-Ph, CF.sub.3), (M-8645, Cl,
CH.sub.3, H, 4-CF.sub.3-Ph, Br), (M-8646, Cl, CH.sub.3, H,
4-CF.sub.3-Ph, CH.sub.3), (M-8647, Cl, CH.sub.3, H,
4-(Me).sub.2N-Ph, H), (M-8648, Cl, CH.sub.3, H, 4-(Me).sub.2N-Ph,
Cl), (M-8649, CL, CH.sub.3, H, 4-(Me).sub.2N-Ph, F), (M-8650, Cl,
CH.sub.3, H, 4-(Me).sub.2N-Ph, CF.sub.3), (M-8651, Cl, CH.sub.3, H,
4-(Me).sub.2N-Ph, Br), (M-8652, Cl, CH.sub.3, H, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-8653, Cl, CH.sub.3, H, 4-OH-Ph, H), (M-8654, Cl,
CH.sub.3, H, 4-OH-Ph, Cl), (M-8655, Cl, CH.sub.3, H, 4-OH-Ph, F),
(M-8656, Cl, CH.sub.3, H, 4-OH-Ph, CF.sub.3), (M-8657, Cl,
CH.sub.3, H, 4-OH-Ph, Br), (M-8658, Cl, CH.sub.3, H, 4-OH-Ph,
CH.sub.3), (M-8659, Cl, CH.sub.3, H, 3,4-di-F-Ph, H), (M-8660, Cl,
CH.sub.3, H, 3,4-di-F-Ph, Cl), (M-8661, Cl, CH.sub.3, H,
3,4-di-F-Ph, F), (M-8662, Cl, CH.sub.3, H, 3,4-di-F-Ph, CF.sub.3),
(M-8663, Cl, CH.sub.3, H, 3,4-di-F-Ph, Br), (M-8664, Cl, CH.sub.3,
H, 3,4-di-F-Ph, CH.sub.3), (M-8665, Cl, CH.sub.3, H, 4-COOH-Ph, H),
(M-8666, Cl, CH.sub.3, H, 4-COOH-Ph, Cl), (M-8667, Cl, CH.sub.3, H,
4-COOH-Ph, F), (M-8668, Cl, CH.sub.3, H, 4-COOH-Ph, CF.sub.3),
(M-8669, Cl, CH.sub.3, H, 4-COOH-Ph, Br), (M-8670, Cl, CH.sub.3, H,
4-COOH-Ph, CH.sub.3), (M-8671, Cl, CH.sub.3, H, Bn, H), (M-8672,
Cl, CH.sub.3, H, Bn, Cl), (M-8673, Cl, CH.sub.3, H, Bn, F),
(M-8674, Cl, CH.sub.3, H, Bn, CF.sub.3), (M-8675, Cl, CH.sub.3, H,
Bn, Br), (M-8676, Cl, CH.sub.3, H, Bn, CH.sub.3), (M-8677, Cl,
CH.sub.3, H, 4-F-Bu, H), (M-8678, Cl, CH.sub.3, H, 4-F-Bu, Cl),
(M-8679, Cl, CH.sub.3, H, 4-F-Bn, F), (M-8680, Cl, CH.sub.3, H,
4-F-Bn, CF.sub.3), (M-8681, Cl, CH.sub.3, Ft, 4-F-Bn, Br), (M-8682,
Cl, CH.sub.3, H, 4-F-Bn, CH.sub.3), (M-8683, Cl, CH.sub.3, H, 2-Py,
H), (M-8684, Cl, CH.sub.3, H, 2-Py, Cl), (M-8685, Cl, CH.sub.3, H,
2-Py, F), (M-8686, Cl, CH.sub.3, H, 2-Py, CF.sub.3), (M-8687, Cl,
CH.sub.3, H, 2-Py, Br), (M-8688, Cl, CH.sub.3, H, 2-Py, CH.sub.3),
(M-8689, Cl, CH.sub.3, H, 3-Py, H), (M-8690, Cl, CH.sub.3, H, 3-Py,
Cl), (M-8691, Cl, CH.sub.3, H, 3-Py, F), (M-8692, Cl, CH.sub.3, H,
3-Py, CF.sub.3), (M-8693, Cl, CH.sub.3, H, 3-Py, Br), (M-8694, Cl,
CH.sub.3, H, 3-Py, CH.sub.3), (M-8695, Cl, CH.sub.3, H, 4-Py, H),
(M-8696, Cl, CH.sub.3, H, 4-Py, Cl), (M-8697, Cl, CH.sub.3, H,
4-Py, F), (M-8698, Cl, CH.sub.3, H, 4-Py, CF.sub.3), (M-8699, Cl,
CH.sub.3, H, 4-Py, Br), (M-8700, Cl, CH.sub.3, H, 4-Py, CH.sub.3),
(M-8701, Cl, CH.sub.3, H, 2-Th, H), (M-8702, Cl, CH.sub.3, H, 2-Th,
Cl), (M-8703, Cl, CH.sub.3, H, 2-Th, F), (M-8704, Cl, CH.sub.3, H,
2-Th, CF.sub.3), (M-8705, Cl, CH.sub.3, H, 2-Th, Br), (M-8706, Cl,
CH.sub.3, H, 2-Th, CH.sub.3), (M-8707, Cl, CH.sub.3, H, 3-Th, H),
(M-8708, Cl, CH.sub.3, H, 3-Th, Cl), (M-8709, Cl, CH.sub.3, H,
3-Th, F), (M-8710, Cl, CH.sub.3, H, 3-Th, CF.sub.3), (M-8711, Cl,
CH.sub.3, H, 3-Th, Br), (M-8712, Cl, CH.sub.3, H, 3-Th, CH.sub.3),
(M-8713, Cl, CH.sub.3, H, pyrrazol-2-yl, H), (M-8714, Cl, CH.sub.3,
H, pyrrazol-2-yl, Cl), (M-8715, Cl, CH.sub.3, H, pyrrazol-2-yl, F),
(M-8716, Cl, CH.sub.3, H, pyrrazol-2-yl, CF.sub.3), (M-8717, Cl,
CH.sub.3, H, pyrrazol-2-yl, Br), (M-8718, Cl, CH.sub.3, H,
pyrrazol-2-yl, CH.sub.3), (M-8719, Cl, CH.sub.3, H, pyrrazol-3-yl,
H), (M-8720, Cl, CH.sub.3, H, pyrrazol-3-yl, Cl), (M-8721, Cl,
CH.sub.3< H, pyrrazol-3-yl, F), (M-8722, Cl, CH.sub.3, H,
pyrrazol-3-yl, CF.sub.3), (M-8723, Cl, CH.sub.3, H, pyrrazol-3-yl,
Br), (M-8724, Cl, CH.sub.3, H, pyrrazol-3-yl, CH.sub.3), (M-8725,
Cl, CH.sub.3, H, pyrimidin-2-yl, H), (M-8726, Cl, CH.sub.3, H,
pyrimidin-2-yl, Cl), (M-8727, Cl, CH.sub.3, H, pyrimidin-2-yl, F),
(M-8728, Cl, CH.sub.3, H, pyrimidin-2-yl, CF.sub.3), (M-8729, Cl,
CH.sub.3, H, pyrimidin-2-yl, Br), (M-8730, Cl, CH.sub.3, H,
pyrimidin-2-yl, CH.sub.3), (M-8731, Cl, CH.sub.3, H,
pyrimidin-4-yl, H), (M-8732, Cl, CH.sub.3, H, pyrimidin-4-yl, Cl),
(M-8733, Cl, CH.sub.3, H, pyrimidin-4-yl, F), (M-8734, Cl,
CH.sub.3, H, pyrimidin-4-yl, CF.sub.3), (M-8735, Cl, CH.sub.3, H,
pyrimidin-4-yl, Br), (M-8736, Cl, CH.sub.3, H, pyrimidin-4-yl,
CH.sub.3), (M-8737, Cl, CH.sub.3, H, pyrimidin-5-yl, H), (M-8738,
Cl, CH.sub.3, H, pyrimidin-5-yl, Cl), (M-8739, Cl, CH.sub.3, H,
pyrimidin-5-yl, F), (M-8740, Cl, CH.sub.3, H, pyrimidin-5-yl,
CF.sub.3), (M-8741, Cl, CH.sub.3, H, pyrimidin-6-yl, Br), (M-8742,
Cl, CH.sub.3, H, pyrimidin-5-yl, CH.sub.3), (M-8743, Cl, CH.sub.3,
H, HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-8744, Cl, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-8745, Cl, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-8746, Cl, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8747, Cl, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-8748, Cl, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-8749, Cl, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-8750, Cl, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-8751, Cl, CH.sub.3,
H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8752, Cl, CH.sub.3,
H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8753, Cl,
CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.3, Br), (M-8754,
Cl, CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-8755, Cl, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-8756, Cl,
CH.sub.3, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-8757, Cl, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8758, Cl,
CH.sub.3, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-8759, Cl, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-8760, Cl,
CH.sub.3, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-8761, Cl, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-8762,
Cl, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-8763, Cl, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8764,
Cl, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-8765, Cl, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-8766, Cl, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-8767, Cl, CH.sub.3, H, MeOCH.sub.2, H), (M-8768, Cl, CH.sub.3,
H, MeOCH.sub.2, Cl), (M-8769, Cl, CH.sub.3, H, MeOCH.sub.2, F),
(M-8770, Cl, CH.sub.3, H, MeOCH.sub.2, CF.sub.3), (M-8771, Cl,
CH.sub.3, H, MeOCH.sub.2, Br), (M-8772, Cl, CH.sub.3, H,
MeOCH.sub.2, CH.sub.3), (M-8773, Cl, CH.sub.3, H, EtOCH.sub.2, H),
(M-8774, Cl, CH.sub.3, H, EtOCH.sub.2, Cl), (M-8775, Cl, CH.sub.3,
H, EtOCH.sub.2, F), (M-8776, Cl, CH.sub.3, H, EtOCH.sub.2,
CF.sub.3), (M-8777, Cl, CH.sub.3, H, EtOCH.sub.2, Br), (M-8778, Cl,
CH.sub.3, H, EtOCH.sub.2, CH.sub.3), (M-8779, Cl, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, H), (M-8780, Cl, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, Cl), (M-8781, Cl, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, F), (M-8782, Cl, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-8783, Cl, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, Br), (M-8784, Cl, CH.sub.3, H,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-8785, Cl, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-8786, Cl, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-8787, Cl, CH.sub.3,
H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-8788, Cl, CH.sub.3,
H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-8789, Cl,
CH.sub.3, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-8790,
Cl, CH.sub.3, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-8791, Cl, CH.sub.3, H, MeOCH.sub.2CH.sub.2, H), (M-8792, Cl,
CH.sub.3, H, MeOCH.sub.2CH.sub.2, Cl), (M-8793, Cl, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, F), (M-8794, Cl, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-8795, Cl, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, Br), (M-8796, Cl, CH.sub.3, H,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-8797, Cl, CH.sub.3, H,
HOCH.sub.2, H), (M-8798, Cl, CH.sub.3, H, HOCH.sub.2, Cl), (M-8799,
Cl, CH.sub.3, H, HOCH.sub.2, F), (M-8800, Cl, CH.sub.3, H,
HOCH.sub.2, CF.sub.3), (M-8801, Cl, CH.sub.3, H, HOCH.sub.2, Br),
(M-8802, Cl, CH.sub.3, H, HOCH.sub.2, CH.sub.3), (M-8803, Cl,
CH.sub.3, H, HOCH.sub.2
CH.sub.2, H), (M-8804, Cl, CH.sub.3, H, HOCH.sub.2CH.sub.2, Cl),
(M-8805, Cl, CH.sub.3, H, HOCH.sub.2CH.sub.2, F), (M-8806, Cl,
CH.sub.3, H, HOCH.sub.2CH.sub.2, CF.sub.3), (M-8807, Cl, CH.sub.3,
H, HOCH.sub.2CH.sub.2, Br), (M-8808, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-8809, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-8810, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-8811, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-8812, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8813, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-8814, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-8815, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-8816, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-8817, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8818, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-8819, Cl,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-8820, Cl,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-8821, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-8822, Cl,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl),
(M-8823, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-8824, Cl,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-8825, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-8826, Cl,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3),
(M-8827, Cl, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H),
(M-8828, Cl, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-8829, Cl, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-8830, Cl, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2 CH.sub.2,
CF.sub.3), (M-8831, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-8832, Cl, CH.sub.3, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-8833, Cl,
CH.sub.3, H, (Me).sub.2N, H), (M-8834, Cl, CH.sub.3, H,
(Me).sub.2N, Cl), (M-8835, Cl, CH.sub.3, H, (Me).sub.2N, F),
(M-8836, Cl, CH.sub.3, H, (Me).sub.2N, CF.sub.3), (M-8837, Cl,
CH.sub.3, H, (Me).sub.2N, Br), (M-8838, Cl, CH.sub.3, H,
(Me).sub.2N, CH.sub.3), (M-8839, Cl, CH.sub.3, H,
piperidin-4-yl-methyl, H), (M-8840, Cl, CH.sub.3, H,
piperidin-4-yl-methyl, Cl), (M-8841, Cl, CH.sub.3, H,
piperidin-4-yl-methyl, F), (M-8842, Cl, CH.sub.3, H,
piperidin-4-yl-methyl, CF.sub.3), (M-8843, Cl, CH.sub.3, H,
piperidin-4-yl-methyl, Br), (M-8844, Cl, CH.sub.3, H,
piperidin-4-yl-methyl, CH.sub.3), (M-8845, Cl, CH.sub.3, H,
cyclohexylmethyl, H), (M-8846, Cl, CH.sub.3, H, cyclohexylmethyl,
Cl), (M-8847, Cl, CH.sub.3, H, cyclohexylmethyl, F), (M-8848, Cl,
CH.sub.3, H, cyclohexylmethyl, CF.sub.3), (M-8849, Cl, CH.sub.3, H,
cyclohexylmethyl, Br), (M-8850, Cl, CH.sub.3, H, cyclohexylmethyl,
CH.sub.3), (M-8851, Cl, CH.sub.3, F, H, H), (M-8852, Cl, CH.sub.3,
F, H, Cl), (M-8853, MeO, CH.sub.3, F, H, F), (M-8854, Cl, CH.sub.3,
F, H, CF.sub.3), (M-8855, Cl, CH.sub.3, F, H, Br), (M-8856, Cl,
CH.sub.3, F, H, CH.sub.3), (M-8857, Cl, CH.sub.3, F, F, H),
(M-8858, Cl, CH.sub.3, F, F, Cl), (M-8859, Cl, CH.sub.3, F, F, F),
(M-8860, Cl, CH.sub.3, F, F, CF.sub.3), (M-8861, Cl, CH.sub.3, F,
F, Br), (M-8862, Cl, CH.sub.3, F, F, CH.sub.3), (M-8863, Cl,
CH.sub.3, F, Cl, H), (M-8864, Cl, CH.sub.3, F, Cl, Cl), (M-8865,
Cl, CH.sub.3, F, Cl, F), (M-8866, Cl, CH.sub.3, F, Cl, CF.sub.3),
(M-8867, Cl, CH.sub.3, F, Cl, Br), (M-8868, Cl, CH.sub.3, F, Cl,
CH.sub.3), (M-8869, Cl, CH.sub.3, F, CH.sub.3, H), (M-8870, Cl,
CH.sub.3, F, CH.sub.3, Cl), (M-8871, Cl, CH.sub.3, F, CH.sub.3, F),
(M-8872, Cl, CH.sub.3, F, CH.sub.3, CF.sub.3), (M-8873, Cl,
CH.sub.3, F, CH.sub.3, Br), (M-8874, Cl, CH.sub.3, F, CH.sub.3,
CH.sub.3), (M-8875, Cl, CH.sub.3, F, Et, H), (M-8876, Cl, CH.sub.3,
F, Et, Cl), (M-8877, Cl, CH.sub.3, F, Et, F), (M-8878, Cl,
CH.sub.3, F, Et, CF.sub.3), (M-8879, Cl, CH.sub.3, F, Et, Br),
(M-8880, Cl, CH.sub.3, F, Et, CH.sub.3), (M-8881, Cl, CH.sub.3, F,
n-Pr, H), (M-8882, Cl, CH.sub.3, F, n-Pr, Cl), (M-8883, Cl,
CH.sub.3, F, n-Pr, F), (M-8884, Cl, CH.sub.3, F, n-Pr, CF.sub.3),
(M-8885, Cl, CH.sub.3, F, n-Pr, Br), (M-8886, Cl, CH.sub.3, F,
n-Pr, CH.sub.3), (M-8887, Cl, CH.sub.3, F, c-Pr, H), (M-8888, Cl,
CH.sub.3, F, c-Pr, Cl), (M-8889, Cl, CH.sub.3, F, c-Pr, F),
(M-8890, Cl, CH.sub.3, F, c-Pr, CF.sub.3), (M-8891, Cl, CH.sub.3,
F, c-Pr, Br), (M-8892, Cl, CH.sub.3, F, c-Pr, CH.sub.3), (M-8893,
Cl, CH.sub.3, F, i-Pr, H), (M-8894, Cl, CH.sub.3, F, i-Pr, Cl),
(M-8895, Cl, CH.sub.3, F, i-Pr, F), (M-8896, Cl, CH.sub.3, F, i-Pr,
CF.sub.3), (M-8897, Cl, CH.sub.3, F, i-Pr, Br), (M-8898, Cl,
CH.sub.3, F, i-Pr, CH.sub.3), (M-8899, Cl, CH.sub.3, F, n-Bu, H),
(M-8900, Cl, CH.sub.3, F, n-Bu, Cl), (M-8901, Cl, CH.sub.3, F,
n-Bu, F), (M-8902, Cl, CH.sub.3, F, n-Bu, CF.sub.3), (M-8903, Cl,
CH.sub.3, F, n-Bu, Br), (M-8904, Cl, CH.sub.3, F, n-Bu, CH.sub.3),
(M-8905, Cl, CH.sub.3, F, i-Bu, H), (M-8906, Cl, CH.sub.3, F, i-Bu,
Cl), (M-8907, Cl, CH.sub.3, F, i-Bu, F), (M-8908, Cl, CH.sub.3, F,
i-Bu, CF.sub.3), (M-8909, Cl, CH.sub.3, F, i-Bu, Br), (M-8910, Cl,
CH.sub.3, F, i-Bu, CH.sub.3), (M-8911, Cl, CH.sub.3, F, sec-Bu, H),
(M-8912, Cl, CH.sub.3, F, sec-Bu, Cl), (M-8913, Cl, CH.sub.3, F,
sec-Bu, F), (M-8914, Cl, CH.sub.3, F, sec-Bu, CF.sub.3), (M-8915,
Cl, CH.sub.3, F, sec-Bu, Br), (M-8916, Cl, CH.sub.3, F, sec-Bu,
CH.sub.3), (M-8917, Cl, CH.sub.3, F, n-Pen, H), (M-8918, Cl,
CH.sub.3, F, n-Pen, Cl), (M-8919, Cl, CH.sub.3, F, n-Pen, F),
(M-8920, Cl, CH.sub.3, F, n-Pen, CF.sub.3), (M-8921, Cl, CH.sub.3,
F, n-Pen, Br), (M-8922, Cl, CH.sub.3, F, n-Pen, CH.sub.3), (M-8923,
Cl, CH.sub.3, F, c-Pen, H), (M-8924, Cl, CH.sub.31 F, c-Pen, Cl),
(M-8925, Cl, CH.sub.3, F, c-Pen, F), (M-8926, Cl, CH.sub.3, F,
c-Pen, CF.sub.3), (M-8927, Cl, CH.sub.3, F, c-Pen, Br), (M-8928,
Cl, CH.sub.3, F, c-Pen, CH.sub.3), (M-8929, Cl, CH.sub.3, F, n-Hex,
H), (M-8930, Cl, CH.sub.3, F, n-Hex, Cl), (M-8931, Cl, CH.sub.3, F,
n-Hex, F), (M-8932, Cl, CH.sub.3, F, n-Hex, CF.sub.3), (M-8933, Cl,
CH.sub.3, F, n-Hex, Br), (M-8934, Cl, CH.sub.3, F, n-Hex,
CH.sub.3), (M-8935, Cl, CH.sub.3, F, c-Hex, H), (M-8936, Cl,
CH.sub.3, F, c-Hex, Cl), (M-8937, Cl, CH.sub.3, F, c-Hex, F),
(M-8938, Cl, CH.sub.3, F, c-Hex, CF.sub.3), (M-8939, Cl, CH.sub.3,
F, c-Hex, Br), (M-8940, Cl, CH.sub.3, F, c-Hex, CH.sub.3), (M-8941,
Cl, CH.sub.3, F, OH, H), (M-8942, Cl, CH.sub.3, F, OH, Cl),
(M-8943, Cl, CH.sub.3, F, OH, F), (M-8944, Cl, CH.sub.3, F, OH,
CF.sub.3), (M-8945, Cl, CH.sub.3, F, OH, Br), (M-8946, Cl,
CH.sub.3, F, OH, CH.sub.3), (M-8947, Cl, CH.sub.3, F, EtO, H),
(M-8948, Cl, CH.sub.3, F, EtO, Cl), (M-8949, Cl, CH.sub.3, F, EtO,
F), (M-8950, Cl, CH.sub.3, F, EtO, CF.sub.3), (M-8951, Cl,
CH.sub.3, F, EtO, Br), (M-8952, Cl, CH.sub.3, F, EtO, CH.sub.3),
(M-8953, Cl, CH.sub.3, F, n-PrO, H), (M-8954, Cl, CH.sub.3, F,
n-PrO, Cl), (M-8955, Cl, CH.sub.3, F, n-PrO, F), (M-8956, Cl,
CH.sub.3, F, n-PrO, CF.sub.3), (M-8957, Cl, CH.sub.3, F, n-PrO,
Br), (M-8958, Cl, CH.sub.3, F, n-PrO, CH.sub.3), <M-8959, Cl,
CH.sub.3, F, PhO, H), (M-8960, Cl, CH.sub.3, F, PhO, Cl), (M-8961,
Cl, CH.sub.3, F, PhO, F), (M-8962, Cl, CH.sub.3, F, PhO, CF.sub.3),
(M-8963, Cl, CH.sub.3, F, PhO, Br), (M-8964, Cl, CH.sub.3, F, PhO,
CH.sub.3), (M-8965, Cl, CH.sub.3, F, BnO, H), (M-8966, Cl,
CH.sub.3, F, BnO, Cl), (M-8967, Cl, CH.sub.3, F, BnO, F), (M-8968,
Cl, CH.sub.3, F, BnO, CF.sub.3), (M-8969, Cl, CH.sub.3, F, BnO,
Br), (M-8970, Cl, CH.sub.3, F, BnO, CH.sub.3), (M-8971, Cl,
CH.sub.3, F, PhCH.sub.2CH.sub.2O, H), (M-8972, Cl, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, Cl), (M-8973, Cl, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, F), (M-8974, Cl, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-8975, Cl, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, Br), (M-8976, Cl, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-8977, Cl, CH.sub.3, F,
CF.sub.3O, H), (M-8978, Cl, CH.sub.3, F, CF.sub.3O, Cl), (M-8979,
Cl, CH.sub.3, F, CF.sub.3O, F), (M-8980, Cl, CH.sub.3, F,
CF.sub.3O, CF.sub.3), (M-8981, Cl, CH.sub.3, F, CF.sub.3O, Br),
(M-8982, Cl, CH.sub.3, F, CF.sub.3O, CH.sub.3), (M-8983, Cl,
CH.sub.3, F, Ph, H), (M-8984, Cl, CH.sub.3, F, Ph, Cl), (M-8985,
Cl, CH.sub.3, F, Ph, F), (M-8986, Cl, CH.sub.3, F, Ph, CF.sub.3),
(M-8987, Cl, CH.sub.3, F, Ph, Br), (M-8988, Cl, CH.sub.3, F, Ph,
CH.sub.3), (M-8989, Cl, CH.sub.3, F, 4-F-Ph, H), (M-8990, Cl,
CH.sub.3, F, 4-F-Ph, Cl), (M-8991, Cl, CH.sub.3, F, 4-F-Ph, F),
(M-8992, Cl, CH.sub.3, F, 4-F-Ph, CF.sub.3), (M-8993, Cl, CH.sub.3,
F, 4-F-Ph, Br), (M-8994, Cl, CH.sub.3, F, 4-F-Ph, CH.sub.3),
(M-8995, Cl, CH.sub.3, F, 4-CF.sub.3-Ph, H), (M-8996, Cl, CH.sub.3,
F, 4-CF.sub.3-Ph, Cl), (M-8997, Cl, CH.sub.3, F, 4-CF.sub.3-Ph, F),
(M-8998, Cl, CH.sub.3, F, 4-CF.sub.3-Ph, CF.sub.3), (M-8999, Cl,
CH.sub.3, F, 4-CF.sub.3-Ph, Br), (M-9000, Cl, CH.sub.3, F,
4-CF.sub.3-Ph, CH.sub.3), (M-9001, Cl, CH.sub.3, F,
4-(Me).sub.2N-Ph, H), (M-9002, Cl, CH.sub.3, F, 4-(Me).sub.2N-Ph,
Cl), (M-9003, Cl, CH.sub.3, F, 4-(Me).sub.2N-Ph, F), (M-9004, Cl,
CH.sub.3, F, 4-(Me).sub.2N-Ph, CF.sub.3), (M-9005, Cl, CH.sub.3, F,
4-(Me).sub.2N-Ph, Br), (M-9006, Cl, CH.sub.3, F, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-9007, Cl, CH.sub.3, F, 4-OH-Ph, H), (M-9008, Cl,
CH.sub.3, F, 4-OH-Ph, Cl), (M-9009, Cl, CH.sub.3, F, 4-OH-Ph, F),
(M-9010, Cl, CH.sub.3, F, 4-OH-Ph, CF.sub.3), (M-9011, Cl,
CH.sub.3, F, 4-OH-Ph, Br), (M-9012, Cl, CH.sub.3, F, 4-OH-Ph,
CH.sub.3), (M-9013, Cl, CH.sub.3, F, 3,4-di-F-Ph, H), (M-9014, Cl,
CH.sub.3, F, 3,4-di-F-Ph, Cl), (M-9015, Cl, CH.sub.3, F,
3,4-di-F-Ph, F), (M-9016, Cl, CH.sub.3, F, 3,4-di-F-Ph, CF.sub.3),
(M-9017, Cl, CH.sub.3, F, 3,4-di-F-Ph, Br), (M-9018, Cl, CH.sub.3,
F, 3,4-di-F-Ph, CH.sub.3), (M-9019, Cl, CH.sub.3, F, 4-COOH-Ph, H),
(M-9020, Cl, CH.sub.3, F, 4-COOH-Ph, Cl), (M-9021, Cl, CH.sub.3, F,
4-COOH-Ph, F), (M-9022, Cl, CH.sub.3, F, 4-COOH-Ph, CF.sub.3),
(M-9023, Cl, CH.sub.3, F, 4-COOH-Ph, Br), (M-9024, Cl, CH.sub.3, F,
4-COOH-Ph, CH.sub.3), (M-9025, Cl, CH.sub.3, F, Bn, H), (M-9026,
Cl, CH.sub.3, F, Bn, Cl), (M-9027, Cl, CH.sub.3, F, Bn, F),
(M-9028, Cl, CH.sub.3, F, Bn, CF.sub.3), (M-9029, Cl, CH.sub.3, F,
Bn, Br), (M-9030, Cl, CH.sub.3, F, Bn, CH.sub.3), (M-9031, Cl,
CH.sub.3, F, 4-F-Bn, H), (M-9032, Cl, CH.sub.3, F, 4-F-Bn, Cl),
(M-9033, Cl, CH.sub.3, F, 4-F-Bn, F), (M-9034, Cl, CH.sub.3, F,
4-F-Bn, CF.sub.3), (M-9035, Cl, CH.sub.3, F, 4-F-Bn, Br), (M-9036,
Cl, CH.sub.3, F, 4-F-Bn, CH.sub.3), (M-9037, Cl, CH.sub.3, F, 2-Py,
H), (M-9038, Cl, CH.sub.3, F, 2-Py, Cl), (M-9039, Cl, CH.sub.3, F,
2-Py, F), (M-9040, Cl, CH.sub.3, F, 2-Py, CF.sub.3), (M-9041, Cl,
CH.sub.3, F, 2-Py, Br), (M-9042, Cl, CH.sub.3, F, 2-Py, CH.sub.3),
(M-9043, Cl, CH.sub.3, F, 3-Py, H), (M-9044, Cl, CH.sub.3, F, 3-Py,
Cl), (M-9045, Cl, CH.sub.3, F, 3-Py, F), (M-9046, Cl, CH.sub.3, F,
3-Py, CF.sub.3), (M-9047, Cl, CH.sub.3, F, 3-Py, Br), (M-9048, Cl,
CH.sub.3, F, 3-Py, CH.sub.3), (M-9049, Cl, CH.sub.3, F, 4-Py, H),
(M-9050, Cl, CH.sub.3, F, 4-Py, Cl), (M-9051, Cl, CH.sub.3, F,
4-Py, F), (M-9052, Cl, CH.sub.3, F, 4-Py, CF.sub.3), (M-9053, Cl,
CH.sub.3, F, 4-Py, Br), (M-9054, Cl, CH.sub.3, F, 4-Py, CH.sub.3),
(M-9055, Cl, CH.sub.3, F, 2-Th, H), (M-9056, Cl, CH.sub.3, F, 2-Th,
Cl), (M-9057, Cl, CH.sub.3, F, 2-Th, F), (M-9058, Cl, CH.sub.3, F,
2-Th, CF.sub.3), (M-9059, Cl, CH.sub.3, F, 2-Th, Br), (M-9060, Cl,
CH.sub.3, F, 2-Th, CH.sub.3), (M-9061, Cl, CH.sub.3, F, 3-Th, H),
(M-9062, Cl, CH.sub.3, F, 3-Th, Cl), (M-9063, Cl, CH.sub.3, F,
3-Th, F), (M-9064, Cl, CH.sub.3, F, 3-Th, CF.sub.3), (M-9065, Cl,
CH.sub.3, F, 3-Th, Br), (M-9066, Cl, CH.sub.3, F, 3-Th, CH.sub.3),
(M-9067, Cl, CH.sub.3, F, pyrrazol-2-yl, H), (M-9068, Cl, CH.sub.3,
F, pyrrazol-2-yl, Cl), (M-9069, Cl, CH.sub.3, F, pyrrazol-2-yl, F),
(M-9070, Cl, CH.sub.3, F, pyrrazol-2-yl, CF.sub.3), (M-9071, Cl,
CH.sub.3, F, pyrrazol-2-yl, Br), (M-9072, Cl, CH.sub.3, F,
pyrrazol-2-yl, CH.sub.3), (M-9073, Cl, CH.sub.3, F, pyrrazol-3-yl,
H), (M-9074, Cl, CH.sub.3, F, pyrrazol-3-yl, Cl), (M-9075, Cl,
CH.sub.3, F, pyrrazol-3-yl, F), (M-9076, Cl, CH.sub.3, F,
pyrrazol-3-yl, CF.sub.3), (M-9077, Cl, CH.sub.3, F, pyrrazol-5-yl,
Br), (M-9078, Cl, CH.sub.3, F, pyrrazol-3-yl, CH.sub.3), (M-9079,
Cl, CH.sub.3, F, pyrimidin-2-yl, H), (M-9080, Cl, CH.sub.3, F,
pyrimidin-2-yl, Cl), (M-9081, Cl, CH.sub.3, F, pyrimidin-2-yl, F),
(M-9082, Cl, CH.sub.3, F, pyrimidin-2-yl, CF.sub.3), (M-9083, Cl,
CH.sub.3, F, pyrimidin-2-yl, Br), (M-9084, Cl, CH.sub.3, F,
pyrimidin-2-yl, CH.sub.3), (M-9085, Cl, CH.sub.3, F,
pyrimidin-4-yl, H), (M-9086, Cl, CH.sub.3, F, pyrimidin-4-yl, Cl),
(M-9087, Cl, CH.sub.3, F, pyrimidin-4-yl, F), (M-9088, Cl,
CH.sub.3, F, pyrimidin-4-yl, CF.sub.3), (M-9089, Cl, CH.sub.3, F,
pyrimidin-4-yl, Br), (M-9090, Cl, CH.sub.3, F, pyrimidin-4-yl,
CH.sub.3), (M-9091, Cl, CH.sub.3, F, pyrimidin-5-yl, H), (M-9092,
Cl, CH.sub.3, F, pyrimidin-5-yl, Cl), (M-9093, Cl, CH.sub.3, F,
pyrimidin-5-yl, F), (M-9094, Cl, CH.sub.3, F, pyrimidin-5-yl,
CF.sub.3), (M-9095, Cl, CH.sub.3, F, pyrimidin-5-yl, Br), (M-9096,
Cl, CH.sub.3, F, pyrimidin-5-yl, CF.sub.3), (M-9097, Cl, CH.sub.3,
F, HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-9098, Cl, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-9099, Cl, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-9100, Cl, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9101, Cl, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-9102, Cl, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-9103, Cl, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9104, Cl, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-9105, Cl, CH.sub.3,
F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9106, Cl, CH.sub.3,
F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9107, Cl,
CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-9108,
Cl, CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-9109, Cl, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9110, Cl,
CH.sub.3, P, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-9111, Cl, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9112, Cl,
CH.sub.3, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-9113, Cl, CH.sub.3, F,
(Me).sub.3NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-9114, Cl,
CH.sub.3, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-9115, Cl, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9116,
Cl, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-9117, Cl, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9118,
Cl, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-9119, Cl, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-9120, Cl, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-9121, Cl, CH.sub.3, F, MeOCH.sub.2, H), (M-9122, Cl, CH.sub.3,
F, MeOCH.sub.2, Cl), (M-9123, Cl, CH.sub.3, F, MeOCH.sub.2, F),
(M-9124, Cl, CH.sub.3, F, MeOCH.sub.2, CH.sub.3), (M-9125, Cl,
CH.sub.3, F, MeOCH.sub.2, Br), (M-9126, Cl, CH.sub.3
, F, MeOCH.sub.2, CH.sub.3), (M-9127, Cl, CH.sub.3, F, EtOCH.sub.2,
H), (M-9128, Cl, CH.sub.3, F, EtOCH.sub.2, Cl), (M-9129, Cl,
CH.sub.3, F, EtOCH.sub.2, F), (M-9130, Cl, CH.sub.3, F,
EtOCH.sub.2, CF.sub.3), (M-9131, Cl, CH.sub.3, F, EtOCH.sub.2, Br),
(M-9132, Cl, CH.sub.3, F, EtOCH.sub.2, CH.sub.3), (M-9133, Cl,
CH.sub.3, F, EtOCH.sub.2CH.sub.2, H), (M-9134, Cl, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, Cl), (M-9135, Cl, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, F), (M-9136, Cl, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-9137, Cl, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, Br), (M-9138, Cl, CH.sub.3, F,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-9139, Cl, CH.sub.3, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-9140, Cl, CH.sub.3, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.3, Cl), (M-9141, Cl, CH.sub.3,
F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-9142, Cl, CH.sub.3,
F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-9143, Cl,
CH.sub.3, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Be), (M-9144,
Cl, CH.sub.3, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-9145, Cl, CH.sub.3, F, MeOCH.sub.2CH.sub.2, H), (M-9146, Cl,
CH.sub.3, F, MeOCH.sub.2CH.sub.2, Cl), (M-9147, Cl, CH.sub.3, F,
MeOCH.sub.2CH.sub.2, F), (M-9148, Cl, CH.sub.3, F,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-9149, Cl, CH.sub.3, F,
MeOCH.sub.2CH.sub.2, Br), (M-9150, Cl, CH.sub.3, F,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-9151, Cl, CH.sub.3, F,
HOCH.sub.2, H), (M-9152, Cl, CH.sub.3, F, HOCH.sub.2, Cl), (M-9153,
Cl, CH.sub.3, F, HOCH.sub.2, F), (M-9154, Cl, CH.sub.3, F,
HOCH.sub.2, CF.sub.3), (M-9155, Cl, CH.sub.3, F, HOCH.sub.2, Br),
(M-9156, Cl, CH.sub.3, F, HOCH.sub.2, CH.sub.3), (M-9157, Cl,
CH.sub.3, F, HOCH.sub.2CH.sub.2, H), (M-9158, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2, Cl), (M-9159, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2, F), (M-9160, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-9161, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2, Br), (M-9162, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-9163, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-9164, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.3, Cl), (M-9165, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-9166, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9167, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-9168, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-9169, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9170, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-9171, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9172, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9173, Cl,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-9174, Cl,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-9175, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9176, Cl,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl),
(M-9177, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9178, Cl,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-9179, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-9180, Cl,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.3),
(M-9181, Cl, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H),
(M-9182, Cl, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl),
(M-9183, Cl, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-9184, Cl, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CF.sub.3), (M-9185, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-9186, Cl, CH.sub.3, F,
HOCH.sub.2CH.sub.2OCH.sub.3CH.sub.3, CH.sub.3), (M-9187, Cl,
CH.sub.3, F, (Me).sub.2N, H), (M-9188, Cl, CH.sub.3, F,
(Me).sub.2N, Cl), (M-9189, Cl, CH.sub.3, F, (Me).sub.2N, F),
(M-9190, Cl, CH.sub.3, F, (Me).sub.2N, CF.sub.3), (M-9191, Cl,
CH.sub.3, F, (Me).sub.2N, Br), (M-9192, Cl, CH.sub.3, F,
(Me).sub.2N, CH.sub.3), (M-9193, Cl, CH.sub.3, F,
piperidin-4-yl-methyl, H), (M-9194, Cl, CH.sub.3, F,
piperidin-4-yl-methyl, Cl), (M-9195, Cl, CH.sub.3, F,
piperidin-4-yl-methyl, F), (M-9196, Cl, CH.sub.3, F,
piperidin-4-yl-methyl, CF.sub.3), (M-9197, Cl, CH.sub.3, F,
piperidin-4-yl-methyl, Br), (M-9198, Cl, CH.sub.3, F,
piperidin-4-yl-methyl, CH.sub.3), (M-9199, Cl, CH.sub.3, F,
cyclohexylmethyl, H), (M-9200, Cl, CH.sub.3, F, cyclohexylmethyl,
Cl), (M-9201, Cl, CH.sub.3, F, cyclohexylmethyl, F), (M-9202, Cl,
CH.sub.3, F, cyclohexylmethyl, CF.sub.3), (M-9203, Cl, CH.sub.3, F,
cyclohexylmethyl, Br), (M-9204, Cl, CH.sub.3, F, cyclohexylmethyl,
CH.sub.3), (M-9205, Cl, CH.sub.3, Cl, H, H), (M-9206, Cl, CH.sub.3,
Cl, H, Cl), (M-9207, Cl, CH.sub.3, Cl, H, F), (M-9208, Cl,
CH.sub.3, CL H, CF.sub.3), (M-9209, Cl, CH.sub.3, Cl, H, Br),
(M-9210, Cl, CH.sub.3, Cl, H, CH.sub.3), (M-9211, Cl, CH.sub.3, Cl,
F, H), (M-9212, CL, CH.sub.3, Cl, F, Cl), (M-9213, Cl, CH.sub.3,
Cl, F, F), (M-9214, Cl, CH.sub.3, Cl, F, CF.sub.3), (M-9215, Cl,
CH.sub.3, Cl, F, Br), (M-9216, Cl, CH.sub.3, Cl, F, CH.sub.3),
(M-9217, Cl, CH.sub.3, Cl, Cl, H), (M-9218, Cl, CH.sub.3, Cl, Cl,
Cl), (M-9219, Cl, CH.sub.3, Cl, Cl, F), (M-9220, Cl, CH.sub.3, Cl,
Cl, CF.sub.3), (M-9221, Cl, CH.sub.3, Cl, Cl, Br), (M-9222, Cl,
CH.sub.3, Cl, Cl, CH.sub.3), (M-9223, Cl, CH.sub.3, Cl, CH.sub.3,
H), (M-9224, Cl, CH.sub.3, Cl, CH.sub.3, Cl), (M-9225, Cl,
CH.sub.3, Cl, CH.sub.3, F), (M-9226, Cl, CH.sub.3, Cl, CH.sub.3,
CF.sub.3), (M-9227, Cl, CH.sub.3, Cl, CH.sub.3, Br), (M-9228, Cl,
CH.sub.3, Cl, CH.sub.3, CH.sub.3), (M-9229, Cl, CH.sub.3, Cl, Et,
H), (M-9230, Cl, CH.sub.3, Cl, Et, Cl), (M-9231, Cl, CH.sub.3, Cl,
Et, F), (M-9232, Cl, CH.sub.3, Cl, Et, CF.sub.3), (M-9233, Cl,
CH.sub.3, Cl, Et, Br), (M-9234, Cl, CH.sub.3, Cl, Et, CH.sub.3),
(M-9235, Cl, CH.sub.3, Cl, N-Pr, H), (M-9236, Cl, CH.sub.3, Cl,
n-Pr, Cl), (M-9237, Cl, CH.sub.3, Cl, n-Pr, F), (M-9238, Cl,
CH.sub.3, Cl, n-Pr, CF.sub.3), (M-9239, Cl. CH.sub.3, Cl, n-Pr,
Br), (M-9240, Cl, CH.sub.3, Cl, n-Pr, CH.sub.3), (M-9241, Cl,
CH.sub.3, Cl, c-Pr, H), (M-9242, Cl, CH.sub.3, Cl, c-Pr, Cl),
(M-9243, Cl, CH.sub.3, Cl, c-Pr, F), (M-9244, Cl, CH.sub.3, Cl,
c-Pr, CF.sub.3), (M-9245, Cl, CH.sub.3, Cl, c-Pr, Br), (M-9246, Cl,
CH.sub.3, Cl, c-Pr, CH.sub.3), (M-9247, Cl, CH.sub.3, Cl, i-Pr, H),
(M-9248, Cl, CH.sub.3, Cl, i-Pr, Cl), (M-9249, Cl, CH.sub.3, Cl,
i-Pr, F), (M-9250, Cl, CH.sub.3, Cl, i-Pr, CF.sub.3), (M-9251, Cl,
CH.sub.3, Cl, i-Pr, Br), (M-9252, Cl, CH.sub.3, Cl, i-Pr,
CH.sub.3), (M-9253, Cl, CH.sub.3, Cl, n-Bu, H), (M-9254, Cl,
CH.sub.3, Cl, n-Bu, Cl), (M-9255, Cl, CH.sub.3, Cl, n-Bu, F),
(M-9256, Cl, CH.sub.3, Cl, n-Bu, CF.sub.3), (M-9257, Cl, CH.sub.3,
Cl, n-Bu, Br), (M-9258, Cl, CH.sub.3, Cl, n-Bu, CH.sub.3), (M-9259,
Cl, CH.sub.3, Cl, i-Bu, H), (M-9260, Cl, CH.sub.3, Cl, i-Bu, Cl),
(M-9261, Cl, CH.sub.3, Cl, i-Bu, F), (M-9262, Cl, CH.sub.3, Cl,
i-Bu, CF.sub.3), (M-9263, Cl, CH.sub.3, Cl, i-Bu, Br), (M-9264, Cl,
CH.sub.3, Cl, i-Bu, CH.sub.3), (M-9265, Cl, CH.sub.3, Cl, sec-Bu,
H), (M-9266, Cl, CH.sub.3, Cl, sec-Bu, Cl), (M-9267, Cl, CH.sub.3,
Cl, sec-Bu, F), (M-9268, Cl, CH.sub.3, Cl, sec-Bu, CF.sub.3),
(M-9269, Cl, CH.sub.3, Cl, sec-Bu, Br), (M-9270, Cl, CH.sub.3, Cl,
sec-Bu, CH.sub.3), (M-9271, Cl, CH.sub.3, Cl, n-Pen, H), (M-9272,
Cl, CH.sub.3, Cl, n-Pen, Cl), (M-9273, Cl, CH.sub.3, Cl, n-Pen, F),
(M-9274, Cl, CH.sub.3, Cl, n-Pen, CF.sub.3), (M-9275, Cl, CH.sub.3,
Cl, n-Pen, Br), (M-9276, Cl, CH.sub.3, Cl, n-Pen, CH.sub.3),
(M-9277, Cl, CH.sub.3, Cl, c-Pen, H), (M-9278, Cl, CH.sub.3, Cl,
c-Pen, Cl), (M-9279, Cl, CH.sub.3, Cl, c-Pen, F), (M-9280, Cl,
CH.sub.3, Cl, c-Pen, CF.sub.3), (M-9281, Cl, CH.sub.3, Cl, c-Pen,
Br), (M-9282, Cl, CH.sub.3, Cl, c-Pen, CH.sub.3), (M-9283, Cl,
CH.sub.3, Cl, n-Hex, H), (M-9284, Cl, CH.sub.3, Cl, n-Hex, Cl),
(M-9285, Cl, CH.sub.3, Cl, n-Hex, F), (M-9286, Cl, CH.sub.3, Cl,
n-Hex, CF.sub.3), (M-9287, Cl, CH.sub.3, Cl, n-Hex, Br), (M-9288,
Cl, CH.sub.3, Cl, n-Hex, CH.sub.3), (M-9289, Cl, CH.sub.3, CJ,
c-Hex, H), (M-9290, Cl, CH.sub.3, Cl, c-Hex, Cl), (M-9291, Cl,
CH.sub.3, Cl, c-Hex, F), (M-9292, Cl, CH.sub.3, Cl, c-Hex,
CF.sub.3), (M-9293, Cl, CH.sub.3, Cl, c-Hex, Br), (M-9294, Cl,
CH.sub.3, Cl, c-Hex, CH.sub.3), (M-9295, Cl, CH.sub.3, Cl, OH, H),
(M-9296, Cl, CH.sub.3, Cl, OH, Cl), (M-9297, Cl, CH.sub.3, Cl, OH,
F), (M-9298, Cl, CH.sub.3, Cl, OH, CF.sub.3), (M-9299, Cl,
CH.sub.3, Cl, OH, Br), (M-9300, Cl, CH.sub.3, Cl, OH, CH.sub.3),
(M-9301, Cl, CH.sub.3, Cl, EtO, H), (M-9302, Cl, CH.sub.3, Cl, EtO,
Cl), (M-9303, Cl, CH.sub.3, Cl, EtO, F), (M-9304, Cl, CH.sub.3, Cl,
EtO, CF.sub.3), (M-9305, Cl, CH.sub.3, Cl, EtO, Br), (M-9306, Cl,
CH.sub.3, Cl, EtO, CH.sub.3), (M-9307, Cl, CH.sub.3, Cl, n-PrO, H),
(M-9308, Cl, CH.sub.3, Cl, n-PrO, Cl), (M-9309, Cl, CH.sub.3, Cl,
n-PrO, F), (M-9310, Cl, CH.sub.3, Cl, n-PrO, CF.sub.3), (M-9311,
Cl, CH.sub.3, Cl, n-PrO, Br), (M-9312, Cl, CH.sub.3, Cl, n-PrO,
CH.sub.3), (M-9313, Cl, CH.sub.3, Cl, PhO, H), (M-9314, Cl,
CH.sub.3, Cl, PhO, Cl), (M-9315, Cl, CH.sub.3, Cl, PhO, F),
(M-9316, Cl, CH.sub.3, Cl, PhO, CF.sub.3), (M-9317, Cl, CH.sub.3,
Cl, PhO, Br), (M-9318, Cl, CH.sub.3, Cl, PhO, CH.sub.3), (M-9319,
Cl, CH.sub.3, Cl, BnO, H), (M-9320, Cl, CH.sub.3, Cl, BnO, Cl),
(M-9321, Cl, CH.sub.3, Cl, BnO, P), (M-9322, Cl, CH.sub.3, Cl, BnO,
CF.sub.3), (M-9323, Cl, CH.sub.3, Cl, BnO, Br), (M-9324, Cl,
CH.sub.3, Cl, BnO, CH.sub.3), (M-9325, Cl, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, H), (M-9321, Cl, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, Cl), (M-9327, Cl, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, F), (M-9328, Cl, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-9329, Cl, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, Br), (M-9330, Cl, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-9331, Cl, CH.sub.3, Cl,
CF.sub.3O, H), (M-9332, Cl, CH.sub.3, Cl, CF.sub.3O, Cl), (M-9333,
Cl, CH.sub.3, Cl, CF.sub.3O, F), (M-9334, Cl, CH.sub.3, Cl,
CF.sub.3O, CF.sub.3), (M-9335, Cl, CH.sub.3, Cl, CF.sub.3O, Br),
(M-9336, Cl, CH.sub.3, Cl, CF.sub.3O, CH.sub.3), (M-9337, Cl,
CH.sub.3, Cl, Ph, H), (M-9338, Cl, CH.sub.3, Cl, Ph, Cl), (M-9339,
Cl, CH.sub.3, Cl, Ph, F), (M-9340, Cl, CH.sub.3, Cl, Ph, CF.sub.3),
(M-9341, Cl, CH.sub.3, Cl, Ph, Br), (M-9342, Cl, CH.sub.3, Cl, Ph,
CH.sub.3), (M-9343, Cl, CH.sub.3, Cl, 4-F-Ph, H), (M-9344, Cl,
CH.sub.3, Cl, 4-F-Ph, Cl), (M-9345, Cl, CH.sub.3, Cl, 4-F-Ph, F),
(M-9346, Cl, CH.sub.3, Cl, 4-F-Ph, CF.sub.3), (M-9347, Cl,
CH.sub.3, Cl, 4-F-Ph, Br), (M-9348, Cl, CH.sub.3, Cl, 4-F-Ph,
CH.sub.3), (M-9349, Cl, CH.sub.3, Cl, 4-CF.sub.3-Ph, H), (M-9350,
Cl, CH.sub.3, Cl, 4-CF.sub.3-Ph, Cl), (M-9351, Cl, CH.sub.3, Cl,
4-CF.sub.3-Ph, F), (M-9352, Cl, CH.sub.3, Cl, 4-CF.sub.3-Ph,
CF.sub.3), (M-9353, Cl, CH.sub.3, Cl, 4-CF.sub.3-Ph, Br), (M-9354,
Cl, CH.sub.3, Cl, 4-CF.sub.3-Ph, CH.sub.3), (M-9355, Cl, CH.sub.3,
Cl, 4-(Me).sub.2N-Ph, H), (M-9356, Cl, CH.sub.3, Cl,
4-(Me).sub.2N-Ph, Cl), (M-9357, Cl, CH.sub.3, Cl, 4-(Me).sub.2N-Ph,
F), (M-9358, Cl, CH.sub.3, Cl, 4-(Me).sub.2N-Ph, CF.sub.3),
(M-9359, Cl, CH.sub.3, Cl, 4-(Me).sub.2N-Ph, Br), (M-9360, Cl,
CH.sub.3, Cl, 4-(Me).sub.2N-Ph, CH.sub.3), (M-9361, Cl, CH.sub.3,
Cl, 4-OH-Ph, H), (M-9362, Cl, CH.sub.3, Cl, 4-OH-Ph, Cl), (M-9363,
Cl, CH.sub.3, Cl, 4-OH-Ph, F), (M-9364, Cl, CH.sub.3, Cl, 4-OH-Ph,
CF.sub.3), (M-9365, Cl, CH.sub.3, Cl, 4-OH-Ph, Br), (M-9366, Cl,
CH.sub.3, Cl, 4-OH-Ph, CH.sub.3), (M-9367, Cl, CH.sub.3, Cl,
3,4-di-F-Ph, H), (M-9368, Cl, CH.sub.3, Cl, 3,4-di-F-Ph, Cl),
(M-9369, Cl, CH.sub.3, Cl, 3,4-di-F-Ph, F), (M-9370, Cl, CH.sub.3,
Cl, 3,4-di-F-Ph, CF.sub.3), (M-9371, Cl, CH.sub.3, Cl, 3,4-di-F-Ph,
Br), (M-9372, Cl, CH.sub.3, Cl, 3,4-di-F-Ph, CH.sub.3), (M-9373,
Cl, CH.sub.3, Cl, 4-COOH-Ph, H), (M-9374, Cl, CH.sub.3, Cl,
4-COOH-Ph, Cl), (M-9375, Cl, CH.sub.3, Cl, 4-COOH-Ph, F), (M-9376,
Cl, CH.sub.3, Cl, 4-COOH-Ph, CF.sub.3), (M-9377, Cl, CH.sub.3, Cl,
4-COOH-Ph, Br), (M-9378, Cl, CH.sub.3, Cl, 4-COOH-Ph, CH.sub.3),
(M-9379, Cl, CH.sub.3, Cl, Bn, H), (M-9380, Cl, CH.sub.3, Cl, Bn,
Cl), (M-9381, Cl, CH.sub.3, Cl, Bn, F), (M-9382, Cl, CH.sub.3, Cl,
Bn, CF.sub.3), (M-9383, Cl, CH.sub.3, Cl, Bn, Br), (M-9384, Cl,
CH.sub.3, Cl, Bn, CH.sub.3), (M-9385, Cl, CH.sub.3, Cl, 4-F-Bn, H),
(M-9386, Cl, CH.sub.3, Cl, 4-F-Bn, Cl), (M-9387, Cl, CH.sub.3, Cl,
4-F-Bn, F), (M-9388, Cl, CH.sub.3, Cl, 4-F-Bn, CF.sub.3), (M-9389,
Cl, CH.sub.3, Cl, 4-F-Bn, Br), (M-9390, Cl, CH.sub.3, Cl, 4-F-Bn,
CH.sub.3), (M-9391, Cl, CH.sub.3, Cl, 2-Py, H), (M-9392, Cl,
CH.sub.3, Cl, 2-Py, Cl), (M-9393, Cl, CH.sub.3, Cl, 2-Py, F),
(M-9394, Cl, CH.sub.3, Cl, 2-Py, CF.sub.3), (M-9395, Cl, CH.sub.3,
Cl, 2-Py, Br), (M-9396, Cl, CH.sub.3, Cl, 2-Py, CH.sub.3), (M-9397,
Cl, CH.sub.3, Cl, 3-Py, H), (M-9398, Cl, CH.sub.3, Cl, 3-Py, Cl),
(M-9399, Cl, CH.sub.3, Cl, 3-Py, F), (M-9400, Cl, CH.sub.3, Cl,
3-Py, CF.sub.3), (M-9401, Cl, CH.sub.3, Cl, 3-Py, Br), (M-9402, Cl,
CH.sub.3, Cl, 3-Py, CH.sub.3), (M-9403, Cl, CH.sub.3, Cl, 4-Py, H),
(M-9404, Cl, CH.sub.3, Cl, 4-Py, Cl), (M-9405, Cl, CH.sub.3, Cl,
4-Py, F), (M-9406, Cl, CH.sub.3, Cl, 4-Py, CF.sub.3), (M-9407, Cl,
CH.sub.3, Cl, 4-Py, Br), (M-9408, Cl, CH.sub.3, Cl, 4-Py,
CH.sub.3), (M-9409, Cl, CH.sub.3, Cl, 2-Th, H), (M-9410, Cl,
CH.sub.3, Cl, 2-Th, Cl), (M-9411, Cl, CH.sub.3, Cl, 2-Th, F),
(M-9412, Cl, CH.sub.3, Cl, 2-Th, CF.sub.3), (M-9413, Cl, CH.sub.3,
Cl, 2-Th, Br), (M-9414, Cl, CH.sub.3, Cl, 2-Th, CH.sub.3), (M-9415,
Cl, CH.sub.3, Cl, 3-Th, H), (M-9416, Cl, CH.sub.3, Cl, 3-Th, Cl),
(M-9417, Cl, CH.sub.3, Cl, 3-Th, F), (M-9418, Cl, CH.sub.3, Cl,
3-Th, CF.sub.3), (M-9419, Cl, CH.sub.3, Cl, 3-Th, Br), (M-9420, Cl,
CH.sub.3, Cl, 3-Th, CH.sub.3), (M-9421, Cl, CH.sub.3, Cl,
pyrrazol-2-yl, H), (M-9422, Cl, CH.sub.3, Cl, pyrrazol-2-yl, Cl),
(M-9423, Cl, CH.sub.3, Cl, pyrrazol-2-yl, F), (M-9424, Cl,
CH.sub.3, Cl, pyrrazol-2-yl, CF.sub.3), (M-9425, Cl, CH.sub.3, Cl,
pyrrazol-2-yl, Br), (M-9426, Cl, CH.sub.3, Cl, pyrrazol-2-yl,
CH.sub.3), (M-9427, Cl, CH.sub.3, Cl, pyrrazol-3-yl, H), (M-9428,
Cl, CH.sub.3, Cl, pyrrazol-3-yl, Cl), (M-9429, Cl, CH.sub.3, Cl,
pyrrazol-3-yl, F), (M-9430, Cl, CH.sub.3, Cl, pyrrazol-3-yl,
CF.sub.3), (M-9431, Cl, CH.sub.3, Cl, pyrrazol-3-yl, Br), (M-9432,
Cl, CH.sub.3, Cl, pyrrazol-3-yl, CH.sub.3), (M-9433, Cl, CH.sub.3,
Cl, pyrimidin-2-yl, H), (M-9434, Cl, CH.sub.3, Cl, pyrimidin-2-yl,
Cl), (M-9435, Cl, CH.sub.3, Cl, pyrimidin-2-yl, F), (M-9436, Cl,
CH.sub.3, Cl, pyrimidin-2-yl, CF.sub.3), (M-9437, Cl, CH.sub.3, Cl,
pyrimidin-2-yl, Br), (M-9438, Cl, CH.sub.3, Cl, pyrimidin-2-yl,
CH.sub.3), (M-9439, Cl, CH.sub.3, Cl, pyrimidin-4-yl, H), (M-9440,
Cl, CH.sub.3, Cl, pyrimidin-4-yl, Cl), (M-9441, Cl, CH.sub.3, Cl,
pyrimidin-4-yl, F), (M-9442, Cl, CH.sub.3, Cl, pyrimidin-4-yl,
CF.sub.3), (M-9443, Cl, CH.sub.3, Cl, pyrimidin-4-yl, Br), (M-9444,
Cl, CH.sub.3, Cl, pyrimidin-4-yl, CH.sub.3), (M-9445, Cl, CH.sub.3,
Cl, pyrimidin-5-yl, H), (M-9446, Cl, CH.sub.3, Cl, pyrimidin-5-yl,
Cl), (M-9447, Cl, CH.sub.3, Cl, pyrimidin-5-yl, F), (M-9448, Cl,
CH.sub.3, Cl, pyrimidin-5-yl, CF.sub.3), (M-9449, Cl, CH.sub.3, Cl,
pyrimidin-5-yl, Br), (M-9450, Cl, CH.sub.3, Cl, pyrimidin-5-yl,
CH.sub.3), (M-9451, Cl, CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2,
H), (M-9452, Cl, CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, Cl),
(M-9453, Cl, CH
.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-9454, Cl,
CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9455, Cl,
CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-9456, Cl,
CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-9457, Cl,
CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9458,
Cl, CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-9459, Cl, CH.sub.3, Cl, HOOCCH.sub.1CH.sub.2CH.sub.2CH.sub.2,
F), (M-9460, Cl, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9461, Cl,
CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-9462,
Cl, CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-9463, Cl, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9464, Cl,
CH.sub.3, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-9465, Cl, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9466, Cl,
CH.sub.3, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-9467, Cl, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-9468, Cl,
CH.sub.3, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-9469, Cl, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9470,
Cl, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-9471, Cl, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9472,
Cl, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-9473, Cl, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-9474, Cl, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-9475, Cl, CH.sub.3, Cl, MeOCH.sub.2, H), (M-9476, Cl, CH.sub.3,
Cl, MeOCH.sub.2, Cl), (M-9477, Cl, CH.sub.3, Cl, MeOCH.sub.2, F),
(M-9478, Cl, CH.sub.3, Cl, MeOCH.sub.2, CF.sub.3), (M-9479, Cl,
CH.sub.3, Cl, MeOCH.sub.2, Br), (M-9480, Cl, CH.sub.3, Cl,
MeOCH.sub.2, CH.sub.3), (M-9481, Cl, CH.sub.3, Cl, EtOCH.sub.2, H),
(M-9482, Cl, CH.sub.3, Cl, EtOCH.sub.2, Cl), (M-9483, Cl, CH.sub.3,
Cl, EtOCH.sub.2, F), (M-9484, Cl, CH.sub.3, Cl, EtOCH.sub.2,
CF.sub.3), (M-9485, Cl, CH.sub.3, Cl, EtOCH.sub.2, Br), (M-9486,
Cl, CH.sub.3, Cl, EtOCH.sub.2, CH.sub.3), (M-9487, Cl, CH.sub.3,
Cl, EtOCH.sub.2CH.sub.2, H), (M-9488, Cl, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, Cl), (M-9489, Cl, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, F), (M-9490, Cl, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-9491, Cl, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, Br), (M-9492, Cl, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-9493, Cl, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-9494, Cl, CH.sub.3,
Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-9495, Cl,
CH.sub.3, Cl, (MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-9496,
Cl, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-9497, Cl, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
Br), (M-9498, Cl, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-9499, Cl,
CH.sub.3, Cl, MeOCH.sub.2CH.sub.2, H), (M-9500, Cl, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, Cl), (M-9501, Cl, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, F), (M-9502, Cl, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-9503, Cl, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, Br), (M-9504, Cl, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-9505, Cl, CH.sub.3, Cl,
HOCH.sub.2, H), (M-9506, Cl, CH.sub.3, Cl, HOCH.sub.2, Cl),
(M-9507, Cl, CH.sub.3, Cl, HOCH.sub.2, F), (M-9508, Cl, CH.sub.3,
Cl, HOCH.sub.2, CF.sub.3), (M-9509, Cl, CH.sub.3, Cl, HOCH.sub.2,
Br), (M-9510, Cl, CH.sub.3, Cl, HOCH.sub.2, CH.sub.3), (M-9511, Cl,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2, H), (M-9512, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, Cl), (M-9513, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, F), (M-9514, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-9515, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, Br), (M-9516, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-9517, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-9518, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-9519, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-9520, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9521, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-9522, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-9523, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9524, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-9525, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9526, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9527, Cl,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-9528, Cl,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-9529, CL, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9530, Cl,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-9531, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9532, Cl,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-9533, Cl, CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2
CH.sub.2CH.sub.2, Br), (M-9534, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-9535, Cl,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-9536, Cl,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.3CH.sub.3, Cl), (M-9537,
Cl, CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-9538,
Cl, CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-9539, Cl, CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
Br), (M-9540, Cl, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-9541, Cl,
CH.sub.3, Cl, (Me).sub.2N, H), (M-9542, Cl, CH.sub.3, Cl,
(Me).sub.2N, Cl), (M-9543, Cl, CH.sub.3, Cl, (Me).sub.2N, F),
(M-9544, Cl, CH.sub.3, Cl, (Me).sub.2N, CF.sub.3), (M-9545, Cl,
CH.sub.3, Cl, (Me).sub.2N, Br), (M-9546, Cl, CH.sub.3, Cl,
(Me).sub.2N, CH.sub.3), (M-9547, Cl, CH.sub.3, Cl,
piperidin-4-yl-methyl, H), (M-9548, Cl, CH.sub.3, Cl,
piperidin-4-yl-methyl, Cl), (M-9549, Cl, CH.sub.3, Cl,
piperidin-4-yl-methyl, F), (M-9550, Cl, CH.sub.3, Cl,
piperidin-4-yl-methyl, CF.sub.3), (M-9551, Cl, CH.sub.3, Cl,
piperidin-4-yl-methyl, Br), (M-9552, Cl, CH.sub.3, Cl,
piperidin-4-yl-methyl, CH.sub.3), (M-9553, Cl, CH.sub.3, Cl,
cyclohexylmethyl, H), (M-9554, Cl, CH.sub.3, Cl, cyclohexylmethyl,
Cl), (M-9555, Cl, CH.sub.3, Cl, cyclohexylmethyl, F), (M-9556, Cl,
CH.sub.3, Cl, cyclohexylmethyl, CF.sub.3), (M-9557, Cl, CH.sub.3,
Cl, cyclohexylmethyl, Br), (M-9558, Cl, CH.sub.3, Cl,
cyclohexylmethyl, CH.sub.3), (M-9559, CH.sub.3, H, H, H, H),
(M-9560, CH.sub.3, H, H, H, Cl), (M-9561, MeO, H, H, H, F),
(M-9562, MeO, H, H, H, CF.sub.3), (M-9563, CH.sub.3, H, H, H, Br),
(M-9564, CH.sub.3, H, H, H, CH.sub.3), (M-9565, MeO, H, H, F, H),
(M-9566, CH.sub.3, H, H, F, Cl), (M-9567, MeO, F, H, F, F),
(M-9568, CH.sub.3, H, H, F, CF.sub.3), (M-9569, CH.sub.3, H, H, F,
Br), (M-9570, CH.sub.3, H, H, F, CH.sub.3), (M-9571, CH.sub.3, H,
H, Cl, H), (M-9572, MeO, F, H, H, i-Pr), (M-9573, CH.sub.3, H, H,
Cl, F), (M-9574, CH.sub.3, H, H, Cl, CF.sub.3), (M-9575, CH.sub.3,
H, H, Cl, Br), (M-9576, CH.sub.3, H, H, Cl, CH.sub.3), (M-9577,
CH.sub.3, H, H, CH.sub.3, H), (M-9578, CH.sub.3, H, H, CH.sub.3,
Cl), (M-9579, CH.sub.3, H, H, CH.sub.3, F), (M-9580, CH.sub.3, H,
H, CH.sub.3, CF.sub.3), (M-9581, CH.sub.3, H, H, CH.sub.3, Br),
(M-9582, CH.sub.3, H, H, CH.sub.3, CH.sub.3), (M-9583, CH.sub.3, H,
H, Et, H), (M-9584, CH.sub.3, H, H, Et, Cl), (M-9585, CH.sub.3, H,
H, Et, F), (M-9586, CH.sub.3, H, H, Et, CF.sub.3), (M-9587,
CH.sub.3, H, H, Et, Br), (M-9588, CH.sub.3, H, H, Et, CH.sub.3),
(M-9589, CH.sub.3, H, H, n-Pr, H), (M-9590, CH.sub.3, H, H, n-Pr,
Cl), (M-9591, CH.sub.3, H, H, n-Pr, F), (M-9592, CH.sub.3, H, H,
n-Pr, CF.sub.3), (M-9593, CH.sub.3, H, H, n-Pr, Br), (M-9594,
CH.sub.3, H, H, n-Pr, CH.sub.3), (M-9595, Et, CH.sub.3, H, H, c-Pr,
H), (M-9596, CH.sub.3, H, H, c-Pr, Cl), (M-9597, CH.sub.3, H, H,
c-Pr, F), (M-9598, CH.sub.3, H, H, c-Pr, CF.sub.3), (M-9599,
CH.sub.3, H, H, c-Pr, Br), (M-9600, CH.sub.3, H, H, c-Pr,
CH.sub.3), (M-9601, CH.sub.3, H, H, i-Pr, H), (M-9602, CH.sub.3, H,
H, i-Pr, Cl), (M-9603, CH.sub.3, H, H, i-Pr, F), (M-9604, CH.sub.3,
H, H, i-Pr, CF.sub.3), (M-9605, CH.sub.3, H, H, i-Pr, Br), (M-9606,
CH.sub.3, H, H, i-Pr, CH.sub.3), (M-9607, CH.sub.3, H, H, n-Bu, H),
(M-9608, CH.sub.3, H, H, n-Bu, Cl), (M-9609, CH.sub.3, H, H, n-Bu,
F), (M-9610, CH.sub.3, H, H, n-Bu, CF.sub.3), (M-9611, CH.sub.3, H,
H, n-Bu, Br), (M-9612, CH.sub.3, H, H, n-Bu, CH.sub.3), (M-9613,
CH.sub.3, H, H, i-Bu, H), (M-9614, CH.sub.3, H, H, i-Bu, Cl),
(M-9615, CH.sub.3, H, H, i-Bu, F), (M-9616, CH.sub.3, H, H, i-Bu,
CF.sub.3), (M-9617, CH.sub.3, H, H, i-Bu, Br), (M-9618, CH.sub.3,
H, H, i-Bu, CH.sub.3), (M-9619, CH.sub.3, H, H, sec-Bu, H),
(M-9620, CH.sub.3, H, H, sec-Bu, Cl), (M-9621, CH.sub.3, H, H,
sec-Bu, F), (M-9622, CH.sub.3, H, H, sec-Bu, CF.sub.3), (M-9623,
CH.sub.3, H, H, sec-Bu, Br), (M-9624, CH.sub.3, H, H, sec-Bu,
CH.sub.3), (M-9625, CH.sub.3, H, H, n-Pen, H), (M-9626, CH.sub.3,
H, H, n-Pen, Cl), (M-9627, CH.sub.3, H, H, n-Pen, F), (M-9628,
CH.sub.3, H, H, n-Pen, CF.sub.3), (M-9629, CH.sub.3, H, H, n-Pen,
Br), (M-9630, CH.sub.3, H, H, n-Pen, CH.sub.3), (M-9631, CH.sub.3,
H, H, c-Pen, H), (M-9632, CH.sub.3, H, H, c-Pen, Cl), (M-9633,
CH.sub.3, H, H, c-Pen, F), (M-9634, CH.sub.3, H, H, c-Pen,
CF.sub.3), (M-9635, CH.sub.3, H, H, c-Pen, Br), (M-9636, CH.sub.3,
H, H, c-Pen, CH.sub.3), (M-9637, CH.sub.3, H, H, n-Hex, H),
(M-9638, CH.sub.3, H, H, n-Hex, Cl), (M-9639, CH.sub.3, H, H,
n-Hex, F), (M-9640, CH.sub.3, H, H, n-Hex, CF.sub.3), (M-9641,
CH.sub.3, H, H, n-Hex, Br), (M-9642, CH.sub.3, H, H, n-Hex,
CH.sub.3), (M-9643, CH.sub.3, H, H, c-Hex, H), (M-9644, CH.sub.3,
H, H, c-Hex, Cl), (M-9645, CH.sub.3, H, H, c-Hex, F), (M-9646,
CH.sub.3, H, H, c-Hex, CF.sub.3), (M-9647, CH.sub.3, H, H, c-Hex,
Br), (M-9648, CH.sub.3, H, H, c-Hex, CH.sub.3), (M-9649, CH.sub.3,
H, H, OH, H), (M-9650, CH.sub.3, H, H, OH, Cl), (M-9651, CH.sub.3,
H, H, OH, F), (M-9652, CH.sub.3, H, H, OH, CF.sub.3), (M-9653,
CH.sub.3, H, H, OH, Br), (M-9654, CH.sub.3, H, H, OH, CH.sub.3),
(M-9655, CH.sub.3, H, H, EtO, H), (M-9656, CH.sub.3, H, H, EtO,
Cl), (M-9657, CH.sub.3, H, H, EtO, F), (M-9658, CH.sub.3, H, H,
EtO, CF.sub.3), (M-9659, CH.sub.3, H, H, EtO, Br), (M-9660,
CH.sub.3, H, H, EtO, CH.sub.3), (M-9661, CH.sub.3, H, H, n-PrO, H),
(M-9662, CH.sub.3, H, H, n-PrO, Cl), (M-9663, CH.sub.3, H, H,
n-PrO, F), (M-9664, CH.sub.3, H, H, n-PrO, CF.sub.3), (M-9665,
CH.sub.3, H, H, n-PrO, Br), (M-9666, CH.sub.3, H, H, n-PrO,
CH.sub.3), (M-9667, CH.sub.3, H, H, PhO, H), (M-9668, CH.sub.3, H,
H, PhO, Cl), (M-9669, CH.sub.3, H, H, PhO, F), (M-9670, CH.sub.3,
H, H, PhO, CF.sub.3), (M-9671, CH.sub.3, H, H, PhO, Br), (M-9672,
CH.sub.3, H, H, PhO, CH.sub.3), (M-9673, CH.sub.3, H, H, BnO, H),
(M-9674, CH.sub.3, H, H, BnO, Cl), (M-9675, CH.sub.3, H, H, BnO,
F), (M-9676, CH.sub.3, H, H, BnO, CF.sub.3), (M-9677, CH.sub.3, H,
H, BnO, Br), (M-9678, CH.sub.3, H, H, BnO, CH.sub.3), (M-9679,
CH.sub.3, H, H, PhCH.sub.2CH.sub.2O, H), (M-9680, CH.sub.3, H, H,
PhCH.sub.2CH.sub.2O, Cl), (M-9681, CH.sub.3, H, H,
PhCH.sub.2CH.sub.2O, F), (M-9682, CH.sub.3, H, H,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-9683, CH.sub.3, H, H,
PhCH.sub.2CH.sub.2O, Br), (M-9684, CH.sub.3, H, H,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-9685, MeO, H, H, CF.sub.3O, H),
(M-9686, CH.sub.3, H, H, CF.sub.3O, Cl), (M-9687, CH.sub.3, H, H,
CF.sub.3O, F), (M-9688, CH.sub.3, H, H, CF.sub.3O, CF.sub.3),
(M-9689, CH.sub.3, H, H, CF.sub.3O, Br), (M-9690, CH.sub.3, H, H,
CF.sub.30, CH.sub.3), (M-9691, CH.sub.3, H, H, Ph, H), (M-9692,
CH.sub.3, H, H, Ph, Cl), (M-9693, CH.sub.3, H, H, Ph, F), (M-9694,
CH.sub.3, H, H, Ph, CF.sub.3), (M-9695, CH.sub.3, H, H, Ph, Br),
(M-9696, CH.sub.3, H, H, Ph, CH.sub.3), (M-9697, CH.sub.3, H, H,
4-F-Ph, H), (M-9698, CH.sub.3, H, H, 4-F-Ph, Cl), (M-9699,
CH.sub.3, H, H, 4-F-Ph, F), (M-9700, CH.sub.3, H, H, 4-F-Ph,
CF.sub.3), (M-9701, CH.sub.3, H, H, 4-F-Ph, Br), (M-9702, CH.sub.3,
H, H, 4-F-Ph, CH.sub.3), (M-9703, CH.sub.3, H, H, 4-CF.sub.3-Ph,
H), (M-9704, CH.sub.3, H, H, 4-CF.sub.3-Ph, Cl), (M-9705, CH.sub.3,
H, H, 4-CF.sub.3-Ph, F), (M-9706, CH.sub.3, H, H, 4-CF.sub.3-Ph,
CF.sub.3), (M-9707, CH.sub.3, H, H, 4-CF.sub.3-Ph, Br), (M-9708,
CH.sub.3, H, H, 4-CF.sub.3-Ph, PhCH.sub.3), (M-9709, CH.sub.3, H,
H, 4-<Me).sub.2N-Ph, H), (M-9710, CH.sub.3, H, H,
4-(Me).sub.2N-Ph, Cl), (M-9711, CH.sub.3, H, H, 4-(Me).sub.2N-Ph,
F), (M-9712, CH.sub.3, H, H, 4-(Me).sub.2N-Ph, CF.sub.3), (M-9713,
CH.sub.3, H, H, 4-(Me).sub.2N-Ph, Br), (M-9714, CH.sub.3, H, H,
4-(Me).sub.2N-Ph, CH.sub.3), (M-9715, CH.sub.3, H, H, 4-OH-Ph, H),
(M-9716, CH.sub.3, H, H, 4-OH-Ph, Cl), (M-9717, CH.sub.3, H, H,
4-OH-Ph, F), (M-9718, CH.sub.3, H, H, 4-OH-Ph, CF.sub.3), (M-9719,
CH.sub.3, H, H, 4-OH-Ph, Br), (M-9720, CH.sub.3, H, H, 4-OH-Ph,
CH.sub.3), (M-9721, CH.sub.3, H, H, 3,4-di-F-Ph, H), (M-9722,
CH.sub.3, H, H, 3,4-di-F-Ph, Cl), (M-9723, CH.sub.3, H, H,
3,4-di-F-Ph, F), (M-9724, CH.sub.3, H, H, 3,4-di-F-Ph, CF.sub.3),
(M-9725, CH.sub.3, H, H, 8,4-di-F-Ph, Br), (M-9726, CH.sub.3, H, H,
3,4-di-F-Ph, CH.sub.3), (M-9727, CH.sub.3, H, H, 4-COOH-Ph, H),
(M-9728, CH.sub.3, H, H, 4-COOH-Ph, Cl), (M-9729, CH.sub.3, H, H,
4-COOH-Ph, F), (M-9730, CH.sub.3, H, H, 4-COOH-Ph, CF.sub.3),
(M-9731, CH.sub.3, H, H, 4-COOH-Ph, Br), (M-9732, CH.sub.3, H, H,
4-COOH-Ph, CH.sub.3), (M-9733, CH.sub.3, H, H, Bn, H), (M-9734,
CH.sub.3, H, H, Bn, Cl), (M-9735, CH.sub.3, H, H, Bn, F), (M-9736,
CH.sub.3, H, H, Bn, CF.sub.3), (M-9737, CH.sub.3, H, H, Bn, Br),
(M-9738, CH.sub.3, H, H, Bn, CH.sub.3), (M-9739, CH.sub.3, H, H,
4-F-Bn, H), (M-9740, CH.sub.3, H, H, 4-F-Bn, Cl), (M-9741,
CH.sub.3, H, H, 4-F-Bn, F), (M-9742, CH.sub.3, H, H, 4-F-Bn,
CF.sub.3), (M-9743, CH.sub.3, H, H, 4-F-Bn, Br), (M-9744, CH.sub.3,
H, H, 4-F-Bn, CH.sub.3), (M-9745, CH.sub.3, H, H, 2-Py, H),
(M-9746, CH.sub.3, H, H, 2-Py, Cl), (M-9747, CH.sub.3, H, H, 2-Py,
F), (M-9748, CH.sub.3, H, H, 2-Py, CF.sub.3), (M-9749, CH.sub.3, H,
H, 2-Py, Br), (M-9750, CH.sub.3, H, H, 2-Py, CH.sub.3), (M-9751,
CH.sub.3, H, H, 3-Py, H), (M-9752, CH.sub.3, H, H, 3-Py, Cl),
(M-9753, CH.sub.3, H, H, 3-Py, F), (M-9754, CH.sub.3, H, H, 3-Py,
CF.sub.3), (M-9755, CH.sub.3, H, H, 3-Py, Br), (M-9756, CH.sub.3,
H, H, 3-Py, CH.sub.3), (M-9757, CH.sub.3, H, H, 4-Py, H), (M-9758,
CH.sub.3, H, H, 4-Py, Cl), (M-9759, CH.sub.3, H, H, 4-Py, F),
(M-9760, CH.sub.3, H, H, 4-Py, CF.sub.3), (M-9761, CH.sub.3, H, H,
4-Py, Br), (M-9762, CH.sub.3, H, H, 4-Py, CH.sub.3), (M-9763,
CH.sub.3, H, H, 2-Th, H), (M-9764, CH.sub.3, H, H, 2-Th, Cl),
(M-9765, CH.sub.3, H, H, 2-Th, F), (M-9766, CH.sub.3, H, H, 2-Th,
CF.sub.3), (M-9767, CH.sub.3, H, H, 2-Th, Br), (M-9768, CH.sub.3,
H, H, 2-Th, CH.sub.3), (M-9769, CH.sub.3, H, H, 3-Th, H), (M-9770,
CH.sub.3, H, H, 3-Th, Cl), (M-9771, CH.sub.3, H, H, 3-Th, F),
(M-9772, CH.sub.3, H, H, 3-Th, CF.sub.3), (M-9773, CH.sub.3, H, H,
3-Th, Br), (M-9774, CH.sub.3, H, H, 3-Th, CH.sub.3), (M-9775,
CH.sub.3, H, H, pyrrazol-2-yl, H), (M-9776, CH
.sub.3, H, H, pyrrazol-2-yl, Cl), (M-9777, CH.sub.3, H, H,
pyrrazol-2-yl, F), (M-9778, CH.sub.3, H, H, pyrrazol-2-yl,
CF.sub.3), (M-9779, CH.sub.3, H, H, pyrrazol-2-yl, Br), (M-9780,
CH.sub.3, H, H, pyrrazol-2-yl, CH.sub.3), (M-9781, CH.sub.3, H, H,
pyrrazol-3-yl, H), (M-9782, CH.sub.3, H, H, pyrrazol-3-yl, Cl),
(M-9783, CH.sub.3, H, H, pyrrazol-3-yl, F), (M-9784, CH.sub.3, H,
H, pyrrazol-3-yl, CF.sub.3), (M-9785, CH.sub.3, H, H,
pyrrazol-3-yl, Br), (M-9786, CH.sub.3, H, H, pyrrazol-3-yl,
CH.sub.3), (M-9787, CH.sub.3, H, H, pyrimidin-2-yl, H), (M-9788,
CH.sub.3, H, H, pyrimidin-2-yl, Cl), (M-9789, CH.sub.3, H, H,
pyrimidin-2-yl, F), (M-9790, CH.sub.3, H, H, pyrimidin-2-yl,
CF.sub.3), (M-9791, CH.sub.3, H, H, pyrimidin-2-yl, Br), (M-9792,
CH.sub.3, H, H, pyrimidin-2-yl, CH.sub.3), (M-9793, CH.sub.3, H, H,
pyrimidin-4-yl, H), (M-9794, CH.sub.3, H, H, pyrimidin-4-yl, Cl),
(M-9795, CH.sub.3, H, H, pyrimidin-4-yl, F), (M-9796, CH.sub.3, H,
H, pyrimidin-4-yl, CF.sub.3), (M-9797, CH.sub.3, H, H,
pyrimidin-4-yl, Br), (M-9798, CH.sub.3, H, H, pyrimidin-4-yl,
CH.sub.3), (M-9799, CH.sub.3, H, H, pyrimidin-5-yl, H), (M-9800,
CH.sub.3, H, H, pyrimidin-5-yl, Cl), (M-9801, CH.sub.3, H, H,
pyrimidin-5-yl, F), (M-9802, CH.sub.3, H, H, pyrimidin-5-yl,
CF.sub.3), (M-9803, CH.sub.3, H, H, pyrimidin-5-yl, Br), (M-9804,
CH.sub.3, H, H, pyrimidin-5-yl, CH.sub.3), (M-9805, CH.sub.3, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2H), (M-9806, CH.sub.3, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2Cl), (M-9807, CH.sub.3, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-9808, CH.sub.3, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9809, CH.sub.3, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-9810, CH.sub.3, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-9811, CH.sub.3, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9812, CH.sub.3, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-9813, CH.sub.3, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9814, CH.sub.3, H, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9815, CH.sub.3,
H, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-9816, CH.sub.3,
H, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-9817,
CH.sub.3, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-9818, CH.sub.3, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-9819,
CH.sub.3, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-9820, CH.sub.3, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9821,
CH.sub.3, H, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-9822, CH.sub.3, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-9823,
CH.sub.3, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3, H), (M-9824,
CH.sub.3, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-9825,
CH.sub.3, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9826,
CH.sub.3, H H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-9827, CH.sub.3, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-9828, CH.sub.3, H, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-9829, CH.sub.3, H, H, MeOCH.sub.2, H), (M-9830, CH.sub.3, H, H,
MeOCH.sub.2, Cl), (M-9831, CH.sub.3, H, H, MeOCH.sub.2, F),
(M-9832, CH.sub.3, H, H, MeOCH.sub.2, CF.sub.3), (M-9833, CH.sub.3,
H, H, MeOCH.sub.2, Br), (M-9834, CH.sub.3, H, H, MeOCH.sub.2,
CH.sub.3), (M-9835, CH.sub.3, H, H, EtOCH.sub.2, H), (M-9836,
CH.sub.3, H, H, EtOCH.sub.2, Cl), (M-9837, CH.sub.3, H, H,
EtOCH.sub.2, F), (M-9838, CH.sub.3, H, H, EtOCH.sub.2, CF.sub.3),
(M-9839, CH.sub.3, H, H, EtOCH.sub.2, Br), (M-9840, CH.sub.3, H, H,
EtOCH.sub.2, CH.sub.3), (M-9841, CH.sub.3, H, H,
EtOCH.sub.2CH.sub.2, H), (M-9842, CH.sub.3, H, H,
EtOCH.sub.2CH.sub.2, Cl), (M-9843, CH.sub.3, H, H,
EtOCH.sub.2CH.sub.2, F), (M-9844, CH.sub.3, H, H,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-9845, CH.sub.3, H, H,
EtOCH.sub.2CH.sub.2, Br), (M-9846, CH.sub.3, H, H,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-9847, CH.sub.3, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-9848, CH.sub.3, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-9849, CH.sub.3, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-9850, CH.sub.3, H, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-9851, CH.sub.3,
H, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-9852, CH.sub.3,
H, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-9853,
CH.sub.3, H, H, MeOCH.sub.2CH.sub.2, H), (M-9854, CH.sub.3, H, H,
MeOCH.sub.2CH.sub.2, Cl), (M-9855, CH.sub.3, H, H,
MeOCH.sub.2CH.sub.2, F), (M-9856, CH.sub.3, H, H,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-9857, CH.sub.3, H, H,
MeOCH.sub.2CH.sub.2, Br), (M-9858, CH.sub.3, H, H,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-9859, CH.sub.3, H, H,
HOCH.sub.2, H), (M-9860, CH.sub.3, H, H, HOCH.sub.2, Cl), (M-9861,
CH.sub.3, H, H, HOCH.sub.2, F), (M-9862, CH.sub.3, H, H,
HOCH.sub.2, CF.sub.3), (M-9863, CH.sub.3, H, H, HOCH.sub.2, Br),
(M-9864, CH.sub.3, H, H, HOCH.sub.2, CH.sub.3), (M-9865, CH.sub.3,
H, H, HOCH.sub.2CH.sub.2, H), (M-9866, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2, Cl), (M-9867, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2, F), (M-9868, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-9869, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2, Br), (M-9870, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-9871, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-9872, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-9873, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-9874, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9875, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-9876, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-9877, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-9878, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-9879, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9880, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-9881, CH.sub.3,
H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-9882, CH.sub.3,
H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-9883,
CH.sub.3, H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H),
(M-9884, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.3CH.sub.3, Cl), (M-9885, CH.sub.3,
H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-9886,
CH.sub.3, H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-9887, CH.sub.3, H, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-9888, CH.sub.3,
H, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-9889,
CH.sub.3, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-9890,
CH.sub.3, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-9891,
CH.sub.3, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-9892,
CH.sub.3, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-9893, CH.sub.3, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-9894, CH.sub.3, H, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-9895, CH.sub.3, H, H, (Me).sub.3N, H), (M-9896,
CH.sub.3, H, H, (Me).sub.2N, Cl), (M-9897, CH.sub.3, H, H,
(Me).sub.2H, F), (M-9898, CH.sub.3, H, H, (Me).sub.2N, CF.sub.3),
(M-9899, CH.sub.3, H, H, (Me).sub.2N, Br), (M-9900, CH.sub.3, H, H,
(Me).sub.2N, CH.sub.3), (M-9901, CH.sub.3, H, H,
piperidin-4-yl-methyl, H), (M-9902, CH.sub.3, H, H,
piperidin-4-yl-methyl, Cl), (M-9903, CH.sub.3, H, H,
piperidin-4-yl-methyl, F), (M-9904, CH.sub.3, H, H,
piperidin-4-yl-methyl, CF.sub.3), (M-9905, CH.sub.3, H, H,
piperidin-4-yl-methyl, Br), (M-9906, CH.sub.3, H, H,
piperidin-4-yl-methyl, CH.sub.3), (M-9907, CH.sub.3, H, H,
cyclohexylmethyl, H), (M-9908, CH.sub.3, H, H, cyclohexylmethyl,
Cl), (M-9909, CH.sub.3, H, H, cyclohexylmethyl, F), (M-9910,
CH.sub.3, H, H, cyclohexylmethyl, CF.sub.3), (M-9911, CH.sub.3, H,
H, cyclohexylmethyl, Br), (M-9912, CH.sub.3, H, H,
cyclohexylmethyl, CH.sub.3), (M-9913, CH.sub.3, H, F, H, H),
(M-9914, CH.sub.3, H, F, H, Cl), (M-9915, CH.sub.3, H, F, H, F),
(M-9916, CH.sub.3, H, F, H, CF.sub.3), (M-9917, CH.sub.3, H, F, H,
Br), (M-9918, CH.sub.3, H, F, H, CH.sub.3), (M-9919, CH.sub.3, H,
F, F, H), (M-9920, CH.sub.3, H, F, F, Cl), (M-9921, CH.sub.3, H, F,
F, F), (M-9922, CH.sub.3, H, F, F, CF.sub.3), (M-9923, CH.sub.3, H,
F, F, Br), (M-9924, CH.sub.3, H, F, F, CH.sub.3), (M-9925,
CH.sub.3, H, F, Cl, H), (M-9926, CH.sub.3, H, F, Cl, Cl), (M-9927,
CH.sub.3, H, F, Cl, F), (M-9928, CH.sub.3, H, F, Cl, CF.sub.3),
(M-9929, CH.sub.3, H, F, Cl, Br), (M-9930, CH.sub.3, H, F, Cl,
CH.sub.3), (M-9931, CH.sub.3, H, F, CH.sub.3, H), (M-9932,
CH.sub.3, H, F, CH.sub.3, Cl), (M-9933, CH.sub.3, H, F, CH.sub.3,
F), (M-9934, CH.sub.3, H, F, CH.sub.3, CF.sub.3), (M-9935,
CH.sub.3, H, F, CH.sub.3, Br), (M-9936, CH.sub.3, H, F, CH.sub.3,
CH.sub.3), (M-9937, CH.sub.3, H, F, Et, H), (M-9938, CH.sub.3, H,
F, Et, Cl), (M-9939, CH.sub.3, H, F, Et, F), (M-9940, CH.sub.3, H,
F, Et, CF.sub.3), (M-9941, CH.sub.3, H, F, Et, Br), (M-9942,
CH.sub.3, H, F, Et, CH.sub.3), (M-9943, CH.sub.3, H, F, n-Pr, H),
(M-9944, CH.sub.3, H, F, n-Pr, Cl), (M-9945, CH.sub.3, H, F, n-Pr,
F), (M-9946, CH.sub.3, H, F, n-Pr, CF.sub.3), (M-9947, CH.sub.3, H,
F, n-Pr, Br), (M-9948, CH.sub.3, H, F, n-Pr, CH.sub.3), (M-9949,
CH.sub.3, H, F, c-Pr, H), (M-9950, CH.sub.3, H, F, c-Pr, Cl),
(M-9951, CH.sub.3, H, F, c-Pr, F), (M-9952, CH.sub.3, H, F, c-Pr,
CF.sub.3), (M-9953, CH.sub.3, H, F, c-Pr, Br), (M-9954, CH.sub.3,
H, F, c-Pr, CH.sub.3), (M-9955, CH.sub.3, H, F, i-Pr, H), (M-9956,
CH.sub.3, H, F, i-Pr, Cl), (M-9957, CH.sub.3, H, F, i-Pr, F),
(M-9958, CH.sub.3, H, F, i-Pr, CF.sub.3), (M-9959, CH.sub.3, H, F,
i-Pr, Br), (M-9960, CH.sub.3, H, F, i-Pr, CH.sub.3), (M-9961,
CH.sub.3, H, F, n-Bu, H), (M-9962, CH.sub.3, H, F, n-Bu, Cl),
(M-9963, CH.sub.3, H, F, n-Bu, F), (M-9964, CH.sub.3, H, F, n-Bu,
CF.sub.3), (M-9965, CH.sub.3, H, F, n-Bu, Br), (M-9966, CH.sub.3,
H, F, n-Bu, CH.sub.3), (M-9967, CH.sub.3, H, F, i-Bu, H), (M-9968,
CH.sub.3, H, F, i-Bu, Cl), (M-9969, CH.sub.3, H, F, i-Bu, F),
(M-9970, CH.sub.3, H, F, i-Bu, CF.sub.3), (M-9971, CH.sub.3, H, F,
i-Bu, Br), (M-9972, CH.sub.3, H, F, i-Bu, CH.sub.3), (M-9973,
CH.sub.3, H, F, sec-Bu, H), (M-9974, CH.sub.3, H, F, sec-Bu, Cl),
(M-9975, CH.sub.3, H, F, sec-Bu, F), (M-9976, CH.sub.3, H, F,
sec-Bu, CF.sub.3), (M-9977, CH.sub.3, H, F, sec-Bu, Br), (M-9978,
CH.sub.3, H, F, sec-Bu, CH.sub.3), (M-9979, CH.sub.3, H, F, n-Pen,
H), (M-9980, CH.sub.3, H, F, n-Pea, Cl), (M-9981, CH.sub.3, H, F,
n-Pen, F), (M-9982, CH.sub.3, H, F, n-Pen, CF.sub.3), (M-9983,
CH.sub.3, H, F, n-Pen, Br), (M-9984, CH.sub.3, H, F, n-Pen,
CH.sub.3), (M-9985, CH.sub.3, H, F, c-Pen, H), (M-9986, CH.sub.3,
H, F, c-Pen, Cl), (M-9987, CH.sub.3, H, F, c-Pen, F), (M-9988,
CH.sub.3, H, F, c-Pen, CF.sub.3), (M-9989, CH.sub.3, H, F, c-Pen,
Br), (M-9990, CH.sub.3, H, F, c-Pen, CH.sub.3), (M-9991, CH.sub.3,
H, F, n-Hex, H), (M-9992, CH.sub.3, H, F, n-Hex, Cl), (M-9993,
CH.sub.3, H, F, n-Hex, F, (M-9994, CH.sub.3, H, F, n-Hex,
CF.sub.3), (M-9995, CH.sub.3, H, F, n-Hex, Br), (M-9996, CH.sub.3,
H, F, n-Hex, CH.sub.3), (M-9997, CH.sub.3, H, F, c-Hex, H),
(M-9998, CH.sub.3, H, F, c-Hex, Cl), (M-9999, CH.sub.3, H, F,
c-Hex, F), (M-10000, CH.sub.3, H, F, c-Hex, CF.sub.3), (M-10001,
CH.sub.3, H, F, c-Hex, Br), (M-10002, CH.sub.3, H, F, c-Hex,
CH.sub.3), (M-10003, CH.sub.3, H, F, OH, H), (M-10004, CH.sub.3, H,
F, OH, Cl), (M-10005, CH.sub.3, H, F, OH, F), (M-10006, CH.sub.3,
H, F, OH, CF.sub.3), (M-10007, CH.sub.3, H, F, OH, Br), (M-10008,
CH.sub.3, H, F, OH, CH.sub.3), (M-10009, CH.sub.3, H, F, EtO, H),
(M-10010, CH.sub.3, H, F, EtO, Cl), (M-10011, CH.sub.3, H, F, EtO,
F), (M-10012, CH.sub.3, H, F, EtO, CF.sub.3), (M-10013, CH.sub.3,
H, F, EtO, Br), (M-10014, CH.sub.3, H, F, EtO, CH.sub.3), (M-10015,
CH.sub.3, H, F, n-PrO, H), (M-10016, CH.sub.3, H, F, n-PrO, Cl),
(M-10017, CH.sub.3, H, F, n-PrO, F), (M-10018, CH.sub.3, H, F,
n-PrO, CF.sub.3), (M-10019, CH.sub.3, H, F, n-PrO, Br), (M-10020,
CH.sub.3, H, F, n-PrO, CH.sub.3), (M-10021, CH.sub.3, H, F, PhO,
H), (M-10022, CH.sub.3, H, F, PhO, Cl), (M-10023, CH.sub.3, H, F,
PhO, F), (M-10024, CH.sub.3, H, F, PhO, CF.sub.3), (M-10025,
CH.sub.3, H, F, PhO, Br), (M-10026, CH.sub.3, H, F, PhO, CH.sub.3),
(M-10027, CH.sub.3, H, F, BnO, H), (M-10028, CH.sub.3, H, F, BnO,
Cl), (M-10029, CH.sub.3, H, F, BnO, F), (M-10030, CH.sub.3, H, F,
BnO, CF.sub.3), (M-10031, CH.sub.3, H, F, BnO, Br), (M-10032,
CH.sub.3, H, F, BnO, CH.sub.3), (M-10033, CH.sub.3, H, F,
PhCH.sub.2CH.sub.2O, H), (M-10034, CH.sub.3, H, F,
PhCH.sub.2CH.sub.2O, Cl), (M-10035, CH.sub.3, H, F,
PhCH.sub.2CH.sub.2O, F), (M-10036, CH.sub.3, H, F,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-10037, CH.sub.3, H, F,
PhCH.sub.2CH.sub.2O, Br), (M-10038, CH.sub.3, H, F,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-10039, CH.sub.3, H, F,
CF.sub.3O, H), (M-10040, CH.sub.3, H, F, CF.sub.30, Cl), (M-10041,
CH.sub.3, H, F, CF.sub.3O, F), (M-10042, CH.sub.3, H, F, CF.sub.3O,
CF.sub.3), (M-10043, CH.sub.3, H, F, CF.sub.3O, Br), (M-10044,
CH.sub.3, H, F, CF.sub.3O, CH.sub.3), (M-10045, CH.sub.3, H, F, Ph,
H), (M-10046, CH.sub.3, H, F, Ph, Cl), (M-10047, CH.sub.3, H, F,
Ph, F), (M-10048, CH.sub.3, H, F, Ph, CF.sub.3), (M-10049,
CH.sub.3, H, F, Ph, Br), (M-10050, CH.sub.3, H, P, Ph, CF.sub.3),
(M-10051, CH.sub.3, H, F, 4-F-Ph, H), (M-10052, CH.sub.3, H, F,
4-F-Ph, Cl), (M-10053, CH.sub.3, H, F, 4-F-Ph, F), (M-10054,
CH.sub.3, H, F, 4-F-Ph, CF.sub.3), (M-10055, CH.sub.3, H, F,
4-F-Ph, Br), (M-10056, CH.sub.3, H, F, 4-F-Ph, CH.sub.3), (M-10057,
CH.sub.3, H, F, 4-CF.sub.3-Ph, H), (M-10058, CH.sub.3, H, F,
4-CF.sub.3-Ph, Cl), (M-10059, CH.sub.3, H, F, 4-CF.sub.3-Ph, F),
(M-10060, CH.sub.3, H, F, 4-CF.sub.3-Ph, CF.sub.3), (M-10061,
CH.sub.3, H, F, 4-CF.sub.3-Ph, Br), (M-10062, CH.sub.3, H, F,
4-CF.sub.3-Ph, CH.sub.3), (M-10063, CH.sub.3, H, F,
4-(Me).sub.2N-Ph, H), (M-10064, CH.sub.3, H, F, 4-(Me).sub.2N-Ph,
Cl), (M-10065, CH.sub.3, H, F, 4-(Me).sub.2N-Ph, F), (M-10066,
CH.sub.3, H, F, 4-(Me).sub.2N-Ph, CF.sub.3), (M-10067, CH.sub.3, H,
F, 4-(Me).sub.2N-Ph, Br), (M-10068, CH.sub.3, H, F,
4-(Me).sub.2N-Ph, CH.sub.3), (M-10069, CH.sub.3, H, F, 4-OH-Ph, H),
(M-10070, CH.sub.3, H, F, 4-OH-Ph, Cl), (M-10071, CH.sub.3, H, F,
4-OH-Ph, F), (M-10072, CH.sub.3, H, E, 4-OH-Ph, CF.sub.3),
(M-10073, CH.sub.3, H, F, 4-OH-Ph, Br), (M-10074, CH.sub.3, H, F,
4-OH-Ph, CH.sub.3), (M-10075, CH.sub.3, H, F, 3,4-di-F-Ph, H),
(M-10076, CH.sub.3, H, F, 3,4-di-F-Ph, Cl), (M-10077, CH.sub.3, H,
F, 3,4-di-F-Ph, F), (M-10078, CH.sub.3, H, F, 3,4-di-F-Ph,
CF.sub.3), (M-10079, CH.sub.3, H, F, 3,4-di-F-Ph, Br), (M-10080,
CH.sub.3, H, F, 3,4-di-F-Ph, CH.sub.3), (M-10081, CH.sub.3, H, F,
4-COOH-Ph, H), (M-10082, CH.sub.3, H, F, 4-COOH-Ph, Cl), (M-10083,
CH.sub.3, H, F, 4-COOH-Ph, F), (M-10084, CH.sub.3, H, F, 4-COOH-Ph,
CF.sub.3), (M-10085, CH.sub.3, H, F, 4-COOH-Ph, Br), (M-10086,
CH.sub.3, H, F, 4-COOH-Ph, CH.sub.3), (M-10087, CH.sub.3, H, F, Bn,
H), (M-10088, CH.sub.3, H, F, Bn, Cl), (M-10089, CH.sub.3, H, F,
Bn, F), (M-10090, CH.sub.3, H, F, Bn, CF.sub.3), (M-10091,
CH.sub.3, H, F, Bn, Br), (M-10092, CH.sub.3, H, F, Bn, CH.sub.3),
(M-10093, CH.sub.3
, H, F, 4-F-Bn, H), (M-10094, CH.sub.3, H, F, 4-F-Bn, Cl),
(M-10095, CH.sub.3, H, F, 4-F-Bn, F), (M-10096, CH.sub.3, H, F,
4-F-Bn, CF.sub.3), (M-10097, CH.sub.3, H, F, 4-F-Bn, Br), (M-10098,
CH.sub.3, H, F, 4-F-Bn, CH.sub.3), (M-10099, CH.sub.3, H, F, 2-Py,
H), (M-10100, CH.sub.3, H, F, 2-Py, Cl), (M-10101, CH.sub.3, H, F,
2-Py, F), M-10102, CH.sub.3, H, F, 2-Py, CF.sub.3), (M-10103,
CH.sub.3, H, F, 2-Py, Br), (M-10104, CH.sub.3, H, F, 2-Py,
CH.sub.3), (M-10105, CH.sub.3, H, F, 3-Py, H), (M-10106, CH.sub.3,
H, F, 3-Py, Cl), (M-10107, CH.sub.3, H, F, 3-Py, F), (M-10108,
CH.sub.3, H, F, 3-Py, CF.sub.3), (M-10109, CH.sub.3, H, F, 3-Py,
Br), (M-10110, CH.sub.3, H, F, 3-Py, CH.sub.3), (M-10111, CH.sub.3,
H, F, 4-Py, H), (M-10112, CH.sub.3, H, F, 4-Py, Cl), (M-10113,
CH.sub.3, H, F, 4-Py, F), (M-10114, CH.sub.3, H, F, 4-Py,
CF.sub.3), (M-10115, CH.sub.3, H, F, 4-Py, Br), (M-10116, CH.sub.3,
H, F, 4-Py, CH.sub.3), (M-10117, CH.sub.3, H, F, 2-Th, H),
(M-10118, CH.sub.3, H, F, 2-Th, Cl), (M-10119, CH.sub.3, H, F,
2-Th, F), (M-10120, CH.sub.3, H, F, 2-Th, CF.sub.3), (M-10121,
CH.sub.3, H, F, 2-Th, Br), (M-10122, CH.sub.3, H, F, 2-Th,
CH.sub.3), (M-10123, CH.sub.3, H, F, 3-Th, H), (M-10124, CH.sub.3,
H, F, 3-Th, Cl), (M-10125, CH.sub.3, H, F, 3-Th, F), (M-10126,
CH.sub.3, H, F, 3-Th, CF.sub.3), (M-10127, CH.sub.3, H, F, 3-Th,
Br), (M-10128, CH.sub.3, H, F, 3-Th, CH.sub.3), (M-10129, CH.sub.3,
H, F, pyrrazol-2-yl, H), (M-10130, CH.sub.3, H, F, pyrrazol-2-yl,
Cl), (M-10131, CH.sub.3, H, F, pyrrazol-2-yl, F), (M-10132,
CH.sub.3, H, F, pyrrazol-2-yl, CF.sub.3), (M-10133, CH.sub.3, H, F,
pyrrazol-2-yl, Br), (M-10134, CH.sub.3, H, F, pyrrazol-2-yl,
CH.sub.3), (M-10135, CH.sub.3, H, F, pyrrazol-3-yl, H), (M-10136,
CH.sub.3, H, F, pyrrazol-3-yl, Cl), (M-10137, CH.sub.3, H, F,
pyrrazol-3-yl, F), (M-10138, CH.sub.3, H, F, pyrrazol-3-yl,
CF.sub.3), (M-10139, CH.sub.3, H, F, pyrrazol-3-yl, Br), (M-10140,
CH.sub.3, H, F, pyrrazol-3-yl, CH.sub.3), (M-10141, CH.sub.3, H, F,
pyrimidin-2-yl, H), (M-10142, CH.sub.3, H, F, pyrimidin-2-yl, Cl),
(M-10143, CH.sub.3, H, F, pyrimidin-2-yl, F), (M-10144, CH.sub.3,
H, F, pyrimidin-2-yl, CF.sub.3), (M-10145, CH.sub.3, H, F,
pyrimidin-2-yl, Br), (M-10146, CH.sub.3, H, F, pyrimidin-2-yl,
CH.sub.3), (M-10147, CH.sub.3, H, F, pyrimidin-4-yl, H), (M-10148,
CH.sub.3, H, F, pyrimidin-4-yl, Cl), (M-10149, CH.sub.3, H, F,
pyrimidin-4-yl, F), (M-10150, CH.sub.3, H, F, pyrimidin-4-yl,
CF.sub.3), (M-10151, CH.sub.3, H, F, pyrimidin-4-yl, Br), (M-10152,
CH.sub.3, H, F, pyrimidin-4-yl, CH.sub.3), (M-10153, CH.sub.3, H,
F, pyrimidin-5-yl, H), (M-10154, CH.sub.3, H, F, pyrimidin-5-yl,
Cl), (M-10155, CH.sub.3, H, F, pyrimidin-5-yl, F), (M-10156,
CH.sub.3, H, F, pyrimidin-5-yl, CF.sub.3), (M-10157, CH.sub.3, H,
F, pyrimidin-5-yl, Br), (M-10158, CH.sub.3, H, F, pyrimidin-5-yl,
CH.sub.3), (M-10159, CH.sub.3, H, F, HOOCCH.sub.2CH.sub.2CH.sub.2,
H), (M-10160, CH.sub.3, H, F, HOOCCH.sub.2CH.sub.2CH.sub.2Cl),
(M-10161, CH.sub.3, H, F, HOOCCH.sub.2CH.sub.2CH.sub.2, F),
(M-10162, CH.sub.3, H, F, HOOCCH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-10163, CH.sub.3, H, F, HOOCCH.sub.2CH.sub.2CH.sub.2Br),
(M-10164, CH.sub.3, H, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.3),
(M-10165, CH.sub.3, H, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-10166, CH.sub.3, H, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Cl), (M-10167, CH.sub.3, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-10168, CH.sub.3, H, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-10169,
CH.sub.3, H, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-10170, CH.sub.3, H, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-10171, CH.sub.3, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-10172,
CH.sub.3, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-10173, CH.sub.3, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-10174,
CH.sub.3, H, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-10175, CH.sub.3, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-10176,
CH.sub.3, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-10177,
CH.sub.3, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-10178, CH.sub.3, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-10179, CH.sub.3, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-10180, CH.sub.3, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-10181, CH.sub.3, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-10182, CH.sub.3, H, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-10183, CH.sub.3, H, F, MeOCH.sub.2, H), (M-10184, CH.sub.3, H,
F, MeOCH.sub.2, Cl), (M-10185, CH.sub.3, H, F, MeOCH.sub.2, F),
(M-10186, CH.sub.3, H, F, MeOCH.sub.2, CF.sub.3), (M-10187,
CH.sub.3, H, F, MeOCH.sub.2, Br), (M-10188, CH.sub.3, H, F,
MeOCH.sub.2, CH.sub.3), (M-10189, CH.sub.3, H, F, EtOCH.sub.2, H),
(M-10190, CH.sub.3, H, F, EtOCH.sub.2, Cl), (M-10191, CH.sub.3, H,
F, EtOCH.sub.2, F), (M-10192, CH.sub.3, H, F, EtOCH.sub.2,
CF.sub.3), (M-10193, CH.sub.3, H, F, EtOCH.sub.2, Br), (M-10194,
CH.sub.3, H, F, EtOCH.sub.2, CH.sub.3), (M-10195, CH.sub.3, H, F,
EtOCH.sub.2CH.sub.2, H), (M-10196, CH.sub.3, H, F,
EtOCH.sub.2CH.sub.2, Cl), (M-10197, CH.sub.3, H, F,
EtOCH.sub.2CH.sub.2, F), (M-10198, CH.sub.3, H, F,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-10199, CH.sub.3, H, F,
EtOCH.sub.2CH.sub.2, Br), (M-10200, CH.sub.3, H, F,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-10201, CH.sub.3, H, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-10202, CH.sub.3, H, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-10203, CH.sub.3, H,
F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-10204, CH.sub.3, H,
F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-10205,
CH.sub.3, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-10206, CH.sub.3, H, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-10207, CH.sub.3, H, F, MeOCH.sub.2CH.sub.2, H),
(M-10208, CH.sub.3, H, F, MeOCH.sub.2CH.sub.2, Cl), (M-10209,
CH.sub.3, H, F, MeOCH.sub.2CH.sub.2, F), (M-10210, CH.sub.3, H, F,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-10211, CH.sub.3, H, F,
MeOCH.sub.2CH.sub.2, Br), (M-10212, CH.sub.3, H, F,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-10213, CH.sub.3, H, F,
HOCH.sub.2, H), (M-10214, CH.sub.3, H, F, HOCH.sub.2, Cl),
(M-10215, CH.sub.3, H, F, HOCH.sub.2, F), (M-10216, CH.sub.3, H, F,
HOCH.sub.2, CF.sub.3), (M-10217, CH.sub.3, H, F, HOCH.sub.2, Br),
(M-10218, CH.sub.3, H, F, HOCH.sub.2, CH.sub.3), (M-10219,
CH.sub.3, H, F, HOCH.sub.2CH.sub.2, H), (M-10220, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2, Cl), (M-10221, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2, F), (M-10222, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-10223, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2, Br), (M-10224, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-10225, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-10226, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-10227, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-10228, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-10229, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-10230, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-10231, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.3, H), (M-10232, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-10233, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-10234, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-10235, CH.sub.3,
H, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-10236, CH.sub.3,
H, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-10237,
CH.sub.3, H, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H),
(M-10238, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-10239,
CH.sub.3, H, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-10240, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-10241,
CH.sub.3, H, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-10242, CH.sub.3, H, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-10243,
CH.sub.3, H, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-10244,
CH.sub.3, H, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-10245,
CH.sub.3, H, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-10246,
CH.sub.3, H, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-10247, CH.sub.3, H, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-10248, CH.sub.3, H, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-10249, CH.sub.3, H, F, (Me).sub.2N, H), (M-10250,
CH.sub.3, H, F, (Me).sub.2N, Cl), (M-10251, CH.sub.3, H, F,
(Me).sub.2N, F), (M-10252, CH.sub.3, H, F, (Me).sub.2N, CF.sub.3),
(M-10253, CH.sub.3, H, F, (Me).sub.2N, Br), (M-10254, CH.sub.3, H,
F, (Me).sub.2N, CH.sub.3), (M-10255, CH.sub.3, H, F,
piperidin-4-yl-methyl, H), (M-10256, CH.sub.3, H, F,
piperidin-4-yl-methyl, Cl), (M-J 0257, CH.sub.3, H, F,
piperidin-4-yl-methyl, F), (M-10258, CH.sub.3, H, F,
piperidin-4-yl-methyl, CF.sub.3), (M-10259, CH.sub.3, H, F,
piperidin-4-yl-methyl, Br), (M-10260, CH.sub.3, H, F,
piperidin-4-yl-methyl, CH.sub.3), (M-10261, CH.sub.3, H, F,
cyclohexylmethyl, H), (M-10262, CH.sub.3, H, F, cyclohexylmethyl,
Cl), (M-10263, CH.sub.3, H, F, cyclohexylmethyl, F), (M-10264,
CH.sub.3, H, F, cyclohexylmethyl, CF.sub.3), (M-10265, CH.sub.3, H,
F, cyclohexylmethyl, Br), (M-10266, CH.sub.3, H, F,
cyclohexylmethyl, CH.sub.3), (M-102671, CH.sub.3, H, Cl, H, H),
(M-10268, CH.sub.3, H, Cl, H, Cl), (M-10269, CH.sub.3, H, Cl, H,
F), (M-10270, CH.sub.3, H, Cl, H, CF.sub.3), (M-10271, CH.sub.3, H,
Cl, H, Br), (M-10272, CH.sub.3, H, Cl, H, CH.sub.3), (M-10273,
CH.sub.3, H, Cl, F, H), (M-10274, CH.sub.3, H, Cl, F, Cl),
(M-10275, CH.sub.3, H, Cl, F, F), (M-10276, CH.sub.3, H, Cl, F,
CF.sub.3), (M-10277, CH.sub.3, H, Cl, F, Br), (M-10278, CH.sub.3,
H, Cl, F, CH.sub.3), (M-10279, CH.sub.3, H, Cl, Cl, H), (M-10280,
CH.sub.3, H, Cl, Cl, Cl), (M-10281, CH.sub.3, H, Cl, Cl, F),
(M-10282, CH.sub.3, H, Cl, Cl, CF.sub.3), (M-10283, CH.sub.3, H,
Cl, Cl, Br), (M-10284, CH.sub.3, H, Cl, Cl, CH.sub.3), (M-10285,
CH.sub.3, H, Cl, CH.sub.3, H), (M-10286, CH.sub.3, H, Cl, CH.sub.3,
Cl), (M-10287, CH.sub.3, H, Cl, CH.sub.3, F), (M-10288, CH.sub.3,
H, Cl, CH.sub.3, CF.sub.3), (M-10289, CH.sub.3, H, Cl, CH.sub.3,
Br), (M-10290, CH.sub.3, H, Cl, CH.sub.3, CH.sub.3), (M-10291,
CH.sub.3, H, Cl, Et, H), (M-10292, CH.sub.3, H, Cl, Et, Cl),
(M-10293, CH.sub.3, H, Cl, Et, F), (M-10294, CH.sub.3, H, Cl, Et,
CF.sub.3), (M-10295, CH.sub.3, H, Cl, Et, Br), (M-10296, CH.sub.3,
H, Cl, Et, CH.sub.3), (M-10297, CH.sub.3, H, Cl, n-Pr, H),
(M-10298, CH.sub.3, H, Cl, n-Pr, Cl), (M-10299, CH.sub.3, H, Cl,
n-Pr, F), (M-10300, CH.sub.3, H, Cl, n-Pr, CF.sub.3), (M-10301,
CH.sub.3, H, Cl, n-Pr, Br), (M-10302, CH.sub.3, H, Cl, n-Pr,
CH.sub.3), (M-10303, CH.sub.3, H, Cl, c-Pr, H), (M-10304, CH.sub.3,
H, Cl, c-Pr, Cl), (M-10305, CH.sub.3, H, Cl, c-Pr, F), (M-10306,
CH.sub.3, H, Cl, c-Pr, CF.sub.3), (M-10307, CH.sub.3, H, Cl, c-Pr,
Br), (M-10308, CH.sub.3, H, Cl, c-Pr, CH.sub.3), (M-10309,
CH.sub.3, H, Cl, i-Pr, H), (M-10310, CH.sub.3, H, Cl, i-Pr, Cl),
(M-10311, CH.sub.3, H, Cl, i-Pr, F), (M-10312, CH.sub.3, H, Cl,
i-Pr, CF.sub.3), (M-10313, CH.sub.3, H, Cl, i-Pr, Br), (M-10314,
CH.sub.3, H, Cl, i-Pr, CH.sub.3), (M-10315, CH.sub.3, H, Cl, n-Bu,
H), (M-10316, CH.sub.3, H, Cl, n-Bu, Cl), (M-10317, CH.sub.3, H,
Cl, n-Bu, F), (M-10318, CH.sub.3, H, Cl, n-Bu, CF.sub.3), (M-10319,
CH.sub.3, H, Cl, n-Bu, Br), (M-10820, CH.sub.3, H, Cl, n-Bu,
CH.sub.3), (M-10321, CH.sub.3, H, Cl, i-Bu, H), (M-10322, CH.sub.3,
H, Cl, i-Bu, Cl), (M-10323, CH.sub.3, H, Cl, i-Bu, F), (M-10324,
CH.sub.3, H, Cl, i-Bu, CF.sub.3), (M-10325, CH.sub.3, H, Cl, i-Bu,
Br), (M-10326, CH.sub.3, H, Cl, i-Bu, CH.sub.3), (M-10327,
CH.sub.3, H, Cl, sec-Bu, H), (M-10328, CH.sub.3, H, Cl, sec-Bu,
Cl), (M-10329, CH.sub.3, H, Cl, sec-Bu, F), (M-10330, CH.sub.3, H,
Cl, sec-Bu, CF.sub.3), (M-10331, CH.sub.3, H, Cl, sec-Bu, Br),
(M-10332, CH.sub.3, H, Cl, sec-Bu, CH.sub.3), (M-10333, CH.sub.3,
H, Cl, n-Pen, H), (M-10334, CH.sub.3, H, Cl, n-Pen, Cl), (M-10335,
CH.sub.3, H, Cl, n-Pen, F), (M-10336, CH.sub.3, H, Cl, n-Pen,
CF.sub.3), (M-10337, CH.sub.3, H, Cl, n-Pen, Br), (M-10338,
CH.sub.3, H, Cl, n-Pen, CH.sub.3), (M-10339, CH.sub.3, H, Cl,
c-Pen, H), (M-10340, CH.sub.3, H, Cl, c-Pen, Cl), (M-10341,
CH.sub.3, H, Cl, c-Pen, F), (M-10342, CH.sub.3, H, Cl, c-Pen,
CF.sub.3), (M-10343, CH.sub.3, H, Cl, c-Pen, Br), (M-10344,
CH.sub.3, H, Cl, c-Pen, CH.sub.3), (M-10345, CH.sub.3, H, Cl,
n-Hex, H), (M-10346, CH.sub.3, H, Cl, n-Hex, Cl), (M-10347,
CH.sub.3, H, Cl, n-Hex, F), (M-10348, CH.sub.3, H, Cl, n-Hex,
CF.sub.3), (M-10349, CH.sub.3, H, Cl, n-Hex, Br), (M-10350,
CH.sub.3, H, Cl, n-Hex, CH.sub.3), (M-10351, CH.sub.3, H, Cl,
c-Hex, H), (M-10352, CH.sub.3, H, Cl, c-Hex, Cl), (M-10353,
CH.sub.3, H, Cl, c-Hex, F), (M-10354, CH.sub.3, H, Cl, c-Hex,
CF.sub.3), (M-10355, CH.sub.3, H, Cl, c-Hex, Br), (M-10356,
CH.sub.3, H, Cl, c-Hex, CH.sub.3), (M-10357, CH.sub.3, H, Cl, OH,
H), (M-10358, CH.sub.3, H, Cl, OH, Cl), (M-10359, CH.sub.3, H, Cl,
OH, F), (M-10360, CH.sub.3, H, Cl, OH, CF.sub.3), (M-10361,
CH.sub.3, H, Cl, OH, Br), (M-10362, CH.sub.3, H, Cl, OH, CH.sub.3),
(M-10363, CH.sub.3, H, Cl, EtO, H), (M-10364, CH.sub.3, H, Cl, EtO,
Cl), (M-10365, CH.sub.3, H, Cl, EtO, F), (M-10366, CH.sub.3, H, Cl,
EtO, CF.sub.3), (M-10367, CH.sub.3, H, Cl, EtO, Br), (M-10368,
CH.sub.3, H, Cl, EtO, CH.sub.3), (M-10369, CH.sub.3, H, Cl, n-PrO,
H), (M-10370, CH.sub.3, H, Cl, n-PrO, Cl), (M-10371, CH.sub.3, H,
Cl, n-PrO, F), (M-10372, CH.sub.3, H, Cl, n-PrO, CF.sub.3),
(M-10373, CH.sub.3, H, Cl, n-PrO, Br), (M-10374, CH.sub.3, H, Cl,
n-PrO, CH.sub.3), (M-10375, CH.sub.3, H, Cl, PhO, H), (M-10376,
CH.sub.3, H, Cl, PhO, Cl), (M-10377, CH.sub.3, H, Cl, PhO, F),
(M-10378, CH.sub.3, H, Cl, PhO, CF.sub.3), (M-10379, CH.sub.3, H,
Cl, PhO, Br), (M-10380, CH.sub.3, H, Cl, PhO, CH.sub.3), (M-10381,
CH.sub.3, H, Cl, BnO, H), (M-10382, CH.sub.3, H, Cl, BnO, Cl),
(M-10383, CH.sub.3, H, Cl, BnO, F), (M-10384, CH.sub.3, H, Cl, BnO,
CF.sub.3), (M-10385, CH.sub.3, H, Cl, BnO, Br), (M-10386, CH.sub.3,
H, Cl, BnO, CH.sub.3), (M-10387, CH.sub.3, H, Cl,
PhCH.sub.2CH.sub.2O, H), (M-10388, CH.sub.3, H, Cl,
PhCH.sub.1CH.sub.2O, Cl), (M-10389, CH.sub.3, H, Cl,
PhCH.sub.2CH.sub.2O, F), (M-10390, CH.sub.3, H, Cl,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-10391, CH.sub.3, H, Cl,
PhCH.sub.2CH.sub.2O, Br), (M-10392, CH.sub.3, H, Cl,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-10393, CH.sub.3, H, Cl,
CF.sub.3O, H), (M-10394, CH.sub.3, H, Cl, CF.sub.3O, Cl), (M-10395,
CH.sub.3, H, Cl, CF.sub.3O, F), (M-10396, CH.sub.3, H, Cl,
CF.sub.3O, CF.sub.3), (M-10397, CH.sub.3, H, Cl, CF.sub.3O, Br),
(M-10398, CH.sub.3, H, Cl, CF.sub.3O, CH.sub.3), (M-10399,
CH.sub.3, H, Cl, Ph, H), (M-10400, CH.sub.3, H, Cl, Ph, Cl),
(M-10401, CH.sub.3, H, Cl, Ph, F), (M-10402, CH.sub.3, H, Cl, Ph,
CF.sub.3), (M-10403, CH.sub.3, H, Cl, Ph, Br), (M-10404, CH.sub.3,
H, Cl, Ph, CH.sub.3), (M-10405, CH.sub.3, H, Cl, 4-F-Ph, H),
(M-10406, CH.sub.3
, H, Cl, 4-F-Ph, Cl), (M-10407, CH.sub.3, H, Cl, 4-F-Ph, F),
(M-10408, CH.sub.3, H, Cl, 4-F-Ph, CF.sub.3), (M-10409, CH.sub.3,
H, Cl, 4-F-Ph, Br), (M-10410, CH.sub.3, H, Cl, 4-F-Ph, CH.sub.3),
(M-10411, CH.sub.3, H, Cl, 4-CF.sub.3-Ph, H), (M-10412, CH.sub.3,
H, Cl, 4-CF.sub.3-Ph, Cl), (M-10413, CH.sub.3, H, Cl,
4-CF.sub.3-Ph, F), (M-10414, CH.sub.3, H, Cl, 4-CF.sub.3-Ph,
CF.sub.3), (M-10415, CH.sub.3, H, Cl, 4-CF.sub.3-Ph, Br), (M-10416,
CH.sub.3, H, Cl, 4-CF.sub.3-Ph, CF.sub.3), (M-10417, CH.sub.3, H,
Cl, 4-(Me).sub.2N-Ph, H), (M-10418, CH.sub.3, H, Cl,
4-(Me).sub.2N-Ph, Cl), (M-10419, CH.sub.3, H, Cl, 4-(Me).sub.2N-Ph,
F), (M-10420, CH.sub.3, H, Cl, 4-(Me).sub.2N-Ph, CF.sub.3),
(M-10421, CH.sub.3, H, Cl, 4-(Me).sub.2N-Ph, Br), (M-10422,
CH.sub.3, H, Cl, 4-(Me).sub.2N-Ph, CH.sub.3), (M-10423, CH.sub.3,
H, Cl, 4-OH-Ph, H), (M-10424, CH.sub.3, H, Cl, 4-OH-Ph, Cl),
(M-10425, CH.sub.3, H, Cl, 4-OH-Ph, F), (M-10426, CH.sub.3, H, Cl,
4-OH-Ph, CF.sub.3), (M-10427, CH.sub.3, H, Cl, 4-OH-Ph, Br),
(M-10428, CH.sub.3, H, Cl, 4-OH-Ph, CH.sub.3), (M-10429, CH.sub.3,
H, Cl, 3,4-di-F-Ph, H), (M-10430, CH.sub.3, H, Cl, 3,4-di-F-Ph,
Cl), (M-10431, CH.sub.3, H, Cl, 3,4-di-F-Ph, F), (M-10432,
CH.sub.3, H, Cl, 3,4-di-F-Ph, CF.sub.3), (M-10433, CH.sub.3, H, Cl,
3,4-di-F-Ph, Br), (M-10434, CH.sub.3, H, Cl, 3,4-di-F-Ph,
CH.sub.3), (M-10435, CH.sub.3, H, Cl, 4-COOH-Ph, H), (M-10436,
CH.sub.3, H, Cl, 4-COOH-Ph, Cl), (M-10437, CH.sub.3, H, Cl,
4-COOH-Ph, F), (M-10438, CH.sub.3, H, Cl, 4-COOH-Ph, CF.sub.3),
(M-10439, CH.sub.3, H, Cl, 4-COOH-Ph, Br), (M-10440, CH.sub.3, H,
Cl, 4-COOH-Ph, CH.sub.3), (M-10441, CH.sub.3, H, Cl, Bn, H),
(M-10442, CH.sub.3, H, Cl, Bn, Cl), (M-10443, CH.sub.3, H, Cl, Bn,
F), (M-10444, CH.sub.3, H, Cl, Bn, CF.sub.3), (M-10445, CH.sub.3,
H, Cl, Bn, Br), (M-10446, CH.sub.3, H, Cl, Bn, CH.sub.3), (M-10447,
CH.sub.3, H, Cl, 4-F-Bn, H), (M-10448, CH.sub.3, H, Cl, 4-F-Bn,
Cl), (M-10449, CH.sub.3, H, Cl, 4-F-Bn, F), (M-10450, CH.sub.3, H,
Cl, 4-F-Bn, CF.sub.3), (M-10451, CH.sub.3, H, Cl, 4-F-Bn, Br),
(M-10452, CH.sub.3, H, Cl, 4-F-Bn, CH.sub.3), (M-10453, CH.sub.3,
H, Cl, 2-Py, H), (M-10454, CH.sub.3, H, Cl, 2-Py, Cl), (M-10455,
CH.sub.3, H, Cl, 2-Py, F), (M-10456, CH.sub.3, H, Cl, 2-Py,
CF.sub.3), (M-10457, CH.sub.3, H, Cl, 2-Py, Br), (M-10458,
CH.sub.3, H, Cl, 2-Py, CH.sub.3), (M-10459, CH.sub.3, H, Cl, 3-Py,
H), (M-10460, CH.sub.3, H, Cl, 3-Py, Cl), (M-10461, CH.sub.3, H,
Cl, 3-Py, F), (M-10462, CH.sub.3, H, Cl, 3-Py, CF.sub.3), (M-10463,
CH.sub.3, H, Cl, 3-Py, Br), (M-10464, CH.sub.3, H, Cl, 3-Py,
CH.sub.3), (M-10465, CH.sub.3, H, Cl, 4-Py, H), (M-10466, CH.sub.3,
H, Cl, 4-Py, Cl), (M-10467, CH.sub.3, H, Cl, 4-Py, F), (M-10468,
CH.sub.3, H, Cl, 4-Py, CF.sub.3), (M-10469, CH.sub.3, H, Cl, 4-Py,
Br), (M-10470, CH.sub.3, H, Cl, 4-Py, CH.sub.3), (M-10471,
CH.sub.3, H, Cl, 2-Th, H), (M-10472, CH.sub.3, H, Cl, 2-Th, Cl),
(M-10473, CH.sub.3, H, Cl, 2-Th, F), (M-10474, CH.sub.3, H, Cl,
2-Th, CF.sub.3), (M-10475, CH.sub.3, H, Cl, 2-Th, Br), (M-10476,
CH.sub.3, H, Cl, 2-Th, CH.sub.3), (M-10477, CH.sub.3, H, Cl, 3-Th,
H), (M-10478, CH.sub.3, H, Cl, 3-Th, Cl), (M-10479, CH.sub.3, H,
Cl, 3-Th, F), (M-10480, CH.sub.3, H, Cl, 3-Th, CF.sub.3), (M-10481,
CH.sub.3, H, Cl, 3-Th, Br), (M-10482, CH.sub.3, H, Cl, 3-Th,
CH.sub.3), (M-10483, CH.sub.3, H, Cl, pyrrazol-2-yl, H), (M-10484,
CH.sub.3, H, Cl, pyrrazol-2-yl, Cl), (M-10485, CH.sub.3, H, Cl,
pyrrazol-2-yl, F), (M-10486, CH.sub.3, H, Cl, pyrrazol-2-yl,
CF.sub.3), (M-10487, CH.sub.3, H, Cl, pyrrazol-2-yl, Br), (M-10488,
CH.sub.3, H, Cl, pyrrazol-2-yl, CH.sub.3), (M-10489, CH.sub.3, H,
Cl, pyrrazol-3-yl, H), (M-10490, CH.sub.3, H, Cl, pyrrazol-3-yl,
Cl), (M-10491, CH.sub.3, H, Cl, pyrrazol-3-yl, F), (M-10492,
CH.sub.3, H, Cl, pyrrazol-3-yl, CF.sub.3), (M-10493, CH.sub.3, H,
Cl, pyrrazol-3-yl, Br), (M-10494, CH.sub.3, H, Cl, pyrrazol-3-yl,
CH.sub.3), (M-10495, CH.sub.3, H, Cl, pyrimidin-2-yl, H), (M-10496,
CH.sub.3, H, Cl, pyrimidin-2-yl, Cl), (M-10497, CH.sub.3, H, Cl,
pyrimidin-2-yl, F), (M-10498, CH.sub.3, H, Cl, pyrimidin-2-yl,
CF.sub.3), (M-10499, CH.sub.3, H, Cl, pyrimidin-2-yl, Br),
(M-10500, CH.sub.3, H, Cl, pyrimidin-2-yl, CH.sub.3), (M-10501,
CH.sub.3, H, Cl, pyrimidin-4-yl, H), (M-10502, CH.sub.3, H, Cl,
pyrimidin-4-yl, Cl), (M-10503, CH.sub.3, H, Cl, pyrimidin-4-yl, F),
(M-10504, CH.sub.3, H, Cl, pyrimidin-4-yl, CF.sub.3), (M-10505,
CH.sub.3, H, Cl, pyrimidin-4-yl, Br), (M-10506, CH.sub.3, H, Cl,
pyrimidin-4-yl, CH.sub.3), (M-10507, CH.sub.3, H, Cl,
pyrimidin-5-yl, H), (M-10508, CH.sub.3, H, Cl, pyrimidin-5-yl, Cl),
(M-10509, CH.sub.3, H, Cl, pyrimidin-5-yl, F), (M-10510, CH.sub.3,
H, Cl, pyrimidin-5-yl, CF.sub.3), (M-10511, CH.sub.3, H, Cl,
pyrimidin-5-yl, Br), (M-10512, CH.sub.3, H, Cl, pyrimidin-5-yl,
CH.sub.3), (M-10513, CH.sub.3, H, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2,
H), (M-10514, CH.sub.3, H, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, Cl),
(M-10616, CH.sub.3, H, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, F),
(M-10516, CH.sub.3, H, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-10517, CH.sub.3, H, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, Br),
(M-10518, CH.sub.3, H, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-10519, CH.sub.3, H, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
H), (M-10520, CH.sub.3, H, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-10521, CH.sub.3, H,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-10522, CH.sub.3,
H, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-10523,
CH.sub.3, H, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.21 Br),
(M-10524, CH.sub.3, H, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-10525, CH.sub.3, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-10526,
CH.sub.3, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Cl), (M-10527, CH.sub.3, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-10528,
CH.sub.3, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-10529, CH.sub.3, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-10530,
CH.sub.3, H, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-10531, CH.sub.3, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-10532, CH.sub.3, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-10533, CH.sub.3, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-10534, CH.sub.3, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-10535, CH.sub.3, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-10536, CH.sub.3, H, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-10537, CH.sub.3, H, Cl, MeOCH.sub.2, H), (M-10538, CH.sub.3, H,
Cl, MeOCH.sub.2, Cl), (M-10539, CH.sub.3, H, Cl, MeOCH.sub.2, F),
(M-10540, CH.sub.3, H, Cl, MeOCH.sub.2, CF.sub.3), (M-10541,
CH.sub.3, H, Cl, MeOCH.sub.2, Br), (M-10542, CH.sub.3, H, Cl,
MeOCH.sub.2, CH.sub.3), (M-10543, CH.sub.3, H, Cl, EtOCH.sub.2, H),
(M-10544, CH.sub.3, H, Cl, EtOCH.sub.2, Cl), (M-10545, CH.sub.3, H,
Cl, EtOCH.sub.2, F), (M-10546, CH.sub.3, H, Cl, EtOCH.sub.2,
CF.sub.3), (M-10547, CH.sub.3, H, Cl, EtOCH.sub.2, Br), (M-10548,
CH.sub.3, H, Cl, EtOCH.sub.2, CH.sub.3), (M-10549, CH.sub.3, H, Cl,
EtOCH.sub.2CH.sub.2, H), (M-10550, CH.sub.3, H, Cl,
EtOCH.sub.2CH.sub.2, Cl), (M-10551, CH.sub.3, H, Cl,
EtOCH.sub.2CH.sub.2, F), (M-10552, CH.sub.3, H, Cl,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-10553, CH.sub.3, H, Cl,
EtOCH.sub.2CH.sub.2, Br), (M-10554, CH.sub.3, H, Cl,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-10555, CH.sub.3, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-10556, CH.sub.3, H,
Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-10557, CH.sub.3,
H, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-10558,
CH.sub.3, H, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.3, CF.sub.3),
(M-10559, CH.sub.3, H, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
Br), (M-10560, CH.sub.3, H, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-10561,
CH.sub.3, H, Cl, MeOCH.sub.2CH.sub.2, H), (M-10562, CH.sub.3, H,
Cl, MeOCH.sub.2CH.sub.2, Cl), (M-10563, CH.sub.3, H, Cl,
MeOCH.sub.2CH.sub.2, F), (M-10564, CH.sub.3, H, Cl,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-10565, CH.sub.3, H, Cl,
MeOCH.sub.2CH.sub.2, Br), (M-10566, CH.sub.3, H, Cl,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-10567, CH.sub.3, H, Cl,
HOCH.sub.2, H), (M-10568, CH.sub.3, H, Cl, HOCH.sub.2, Cl),
(M-10569, CH.sub.3, H, Cl, HOCH.sub.2, F), (M-10570, CH.sub.3, H,
Cl, HOCH.sub.2, CF.sub.3), (M-10571, CH.sub.3, H, Cl, HOCH.sub.2,
Br), (M-10572, CH.sub.3, H, Cl, HOCH.sub.2, CH.sub.3), (M-10573,
CH.sub.3, H, Cl, HOCH.sub.2CH.sub.2, H), (M-10574, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2, Cl), (M-10575, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2, F), (M-10576, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-10577, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2, Br), (M-10578, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-10579, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-10580, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-10581, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-10582, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-10583, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-10584, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-10585, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-10586, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-10587, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-10588, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-10589, CH.sub.3,
H, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-10590, CH.sub.3,
H, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-10591,
CH.sub.3, H, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-10592, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-10593, CH.sub.3,
H, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-10594,
CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-10595,
CH.sub.3, H, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br),
(M-10596, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-10597,
CH.sub.3, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-10598,
CH.sub.3, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.3, Cl),
(M-10599, CH.sub.3, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-10600, CH.sub.3, H, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CF.sub.3), (M-10601, CH.sub.3, H, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-10602, CH.sub.3, H,
Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-10603,
CH.sub.3, H, Cl, (Me).sub.2N, H), (M-10604, CH.sub.3, H, Cl,
(Me).sub.2N, Cl), (M-10605, CH.sub.3, H, Cl, (Me).sub.2N, F),
(M-10606, CH.sub.3, H, Cl, (Me).sub.2N, CF.sub.3), (M-10607,
CH.sub.3, H, Cl, (Me).sub.2N, Br), (M-10608, CH.sub.3, H, Cl,
(Me).sub.2N, CH.sub.3), (M-10609, CH.sub.3, H, Cl,
piperidin-4-yl-methyl, H), (M-10610, CH.sub.3, H, Cl,
piperidin-4-yl-methyl, Cl), (M-10611, CH.sub.3, H, Cl,
piperidin-4-yl-methyl, F), (M-10612, CH.sub.3, H, Cl,
piperidin-4-yl-methyl, CF.sub.3), (M-10613, CH.sub.3, H, Cl,
piperidin-4-yl-methyl, Br), (M-10614, CH.sub.3, H, Cl,
piperidin-4-yl-methyl, CH.sub.3), (M-10615, CH.sub.3, H, Cl,
cyclohexylmethyl, H), (M-10616, CH.sub.3, H, Cl, cyclohexylmethyl,
Cl), (M-10617, CH.sub.3, H, Cl, cyclohexylmethyl, F), (M-10618,
CH.sub.3, H, Cl, cyclohexylmethyl, CF.sub.3), (M-10619, CH.sub.3,
H, Cl, cyclohexylmethyl, Br), (M-10620, CH.sub.3, H, Cl,
cyclohexylmethyl, CH.sub.3), (M-10621, CH.sub.3, F, H, H, H),
(M-10622, CH.sub.3, F, H, H, Cl), (M-10623, CH.sub.3, F, H, H, F),
(M-10624, CH.sub.3, F, H, H, CF.sub.3), (M-10625, CH.sub.3, F, H,
H, Br), (M-10626, CH.sub.3, F, H, H, CH.sub.3), (M-10627, CH.sub.3,
F, PI, F, H), (M-10628, CH.sub.3, F, H, F, Cl), (M-10629, CH.sub.3,
F, H, F, F), (M-10630, CH.sub.3, F, H, F, CF.sub.3), (M-10631,
CH.sub.3, F, H, F, Br), (M-10632, CH.sub.3, F, H, F, CH.sub.3),
(M-10633, CH.sub.3, F, H, Cl, H), (M-10634, CH.sub.3, F, H, Cl,
Cl), (M-10635, CH.sub.3, F, H, Cl, F), (M-10636, CH.sub.3, F, H,
Cl, CF.sub.3), (M-10637, CH.sub.3, F, H, Cl, Br), (M-10638,
CH.sub.3, F, H, Cl, CH.sub.3), (M-10639, CH.sub.3, F, H, CH.sub.3,
H), (M-10640, CH.sub.3, F, H, CH.sub.3, Cl), (M-10641, CH.sub.3, F,
H, CH.sub.3, F), (M-10642, CH.sub.3, F, H, CH.sub.3, CF.sub.3),
(M-10643, CH.sub.3, F, H, CH.sub.3, Br), (M-10644, CH.sub.3, F, H,
CH.sub.3, CH.sub.3), (M-10645, CH.sub.3, F, H, Et, H), (M-10646,
CH.sub.3, F, H, Et, Cl), (M-10647, CH.sub.3, F, H, Et, F),
(M-10648, CH.sub.3, F, H, Et, CF.sub.3), (M-10649, CH.sub.3, F, H,
Et, Br), (M-10650, CH.sub.3, F, H, Et, CH.sub.3), (M-10651,
CH.sub.3, F, H, n-Pr, H), (M-10652, CH.sub.3, F, H, n-Pr, Cl),
(M-10653, CH.sub.3, F, H, n-Pr, F), (M-10654, CH.sub.3, F, H, n-Pr,
CF.sub.3), (M-10655, CH.sub.3, F, H, n-Pr, Br), (M-10656, CH.sub.3,
F, H, n-Pr, CH.sub.3), (M-10657, CH.sub.3, F, H, c-Pr, H),
(M-10658, CH.sub.3, F, H, c-Pr, Cl), (M-10659, CH.sub.3, F, H,
c-Pr, F), (M-10660, CH.sub.3, F, H, c-Pr, CF.sub.3), (M-10661,
CH.sub.3, F, H, c-Pr, Br), (M-10662, CH.sub.3, F, H, c-Pr,
CH.sub.3), (M-10663, CH.sub.3, F, H, i-Pr, H), (M-10664, CH.sub.3,
F, H, i-Pr, Cl), (M-10665, CH.sub.3, F, H, i-Pr, F), (M-10666,
CH.sub.3, F, H, i-Pr, CF.sub.3), (M-10667, CH.sub.3, F, H, i-Pr,
Br), (M-10668, CH.sub.3, F, H, i-Pr, CH.sub.3), (M-10669, CH.sub.3,
F, H, n-Bu, H), (M-10670, CH.sub.3, F, H, n-Bu, Cl), (M-10671,
CH.sub.3, F, H, n-Bu, F), (M-10672, CH.sub.3, F, H, n-Bu,
CF.sub.3), (M-10673, CH.sub.3, F, H, n-Bu, Br), (M-10674, CH.sub.3,
F, H, n-Bu, CH.sub.3), (M-10675, CH.sub.3, F, H, i-Bu, H),
(M-10676, CH.sub.3, F, H, i-Bu, Cl), (M-10677, CH.sub.3, F, H,
i-Bu, F), (M-10678, CH.sub.3, F, H, i-Bu, CF.sub.3), (M-10679,
CH.sub.3, F, H, i-Bu, Br), (M-10680, CH.sub.3, F, H, i-Bu,
CH.sub.3), (M-10681, CH.sub.3, F, H, sec-Bu, H), (M-10682,
CH.sub.3, F, H, sec-Bu, Cl), (M-10683, CH.sub.3, F, H, sec-Bu, F),
(M-10684, CH.sub.3, F, H, sec-Bu, CF.sub.3), (M-10685, CH.sub.3, F,
H, sec-Bu, Br), (M-10686, CH.sub.3, F, H, sec-Bu, CH.sub.3),
(M-10687, CH.sub.3, F, H, n-Pen, H), (M-10688, CH.sub.3, F, H,
n-Pen, Cl), (M-10689, CH.sub.3, F, H, n-Pen, F), (M-10690,
CH.sub.3, F, H, n-Pen, CF.sub.3), (M-10691, CH.sub.3, F, H, n-Pen,
Br), (M-10692, CH.sub.3, F, H, n-Pen, CH.sub.3), (M-10693,
CH.sub.3, F, H, c-Pen, H), (M-10694, CH.sub.3, F, H, c-Pen, Cl),
(M-10695, CH.sub.3, F, H, c-Pen, F), (M-10696, CH.sub.3, F, H,
c-Pen, CF.sub.3), (M-10697, CH.sub.3, F, H, c-Pen, Br), (M-10698,
CH.sub.3, F, H, c-Pen, CH.sub.3), (M-10699, CH.sub.3, F, H, n-Hex,
H), (M-10700, CH.sub.3, F, H, n-Hex, Cl), (M-10701, CH.sub.3, F, H,
n-Hex, F), (M-10702, CH.sub.3, F, H, n-Hex, CF.sub.3), (M-10703,
CH.sub.3, F, H, n-Hex, Br), (M-10704, CH.sub.3, F, H, n-Hex,
CH.sub.3), (M-10705, CH.sub.3, F, H, c-Hex, H), (M-10706, CH.sub.3,
F, H, c-Hex, Cl), (M-10707, CH.sub.3, F, H, c-Hex, F), (M-10708,
CH.sub.3, F, H, c-Hex, CF.sub.3), (M-10709, CPIs, F, H, c-Hex, Br),
(M-10710, CH.sub.3, F, H, c-Hex, CH.sub.3), (M-10711, CH.sub.3, F,
H, OH, H), (M-10712, CH.sub.3, F, H, OH, Cl), (M-10713, CH.sub.3,
F, H, OH, F), (M-10714, CH
.sub.3, F, H, OH, CF.sub.3), (M-10715, CH.sub.3, F, H, OH, Br),
(M-10716, CH.sub.3, F, H, OH, CH.sub.3), (M-10717, CH.sub.3, F, H,
EtO, H), (M-10718, CH.sub.3, F, H, EtO, Cl), (M-10719, CH.sub.3, F,
H, EtO, F), (M-10720, CH.sub.3, F, H, EtO, CF.sub.3), (M-10721,
CH.sub.3, F, H, EtO, Br), (M-10722, CH.sub.3, F, H, EtO, CH.sub.3),
(M-10723, CH.sub.3, F, H, n-PrO, H), (M-10724, CH.sub.3, F, H,
n-PrO, Cl), (M-10725, CH.sub.3, F, H, n-PrO, F), (M-10726,
CH.sub.3, F, H, n-PrO, CF.sub.3), (M-10727, CH.sub.3, F, H, n-PrO,
Br), (M-10728, CH.sub.3, F, H, n-PrO, CH.sub.3), (M-10729,
CH.sub.3, F, H, PhO, H), (M-10730, CH.sub.3, F, H, PhO, Cl),
(M-10731, CH.sub.3, F, H, PhO, F), (M-10732, CH.sub.3, F, H, PhO,
CF.sub.3), (M-10733, CH.sub.3, F, H, PhO, Br), (M-10734, CH.sub.3,
F, H, PhO, CH.sub.3), (M-10735, CH.sub.3, F, H, BnO, H), (M-10736,
CH.sub.3, F, H, BnO, Cl), (M-10737, CH.sub.3, F, H, BnO, F),
(M-10738, CH.sub.3, F, H, BnO, CF.sub.3), (M-10739, CPIs, F, H,
BnO, Br), (M-10740, CH.sub.3, F, H, BnO, CH.sub.3), (M-10741,
CH.sub.3, F, H, PhCH.sub.2CH.sub.2O, H), (M-10742, CH.sub.3, F, H,
PhCH.sub.2CH.sub.2O, Cl), (M-10743, CH.sub.3, F, H,
PhCH.sub.2CH.sub.2O, F), (M-10744, CH.sub.3, F, H,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-10745, CH.sub.3, F, H,
PhCH.sub.2CH.sub.2O, Br), (M-10746, CH.sub.3, F, H,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-10747, CH.sub.3, F, H,
CF.sub.3O, H), (M-10748, CH.sub.3, F, H, CF.sub.3O, Cl), (M-10749,
CH.sub.3, F, H, CF.sub.3O, F), (M-10750, CH.sub.3, F, H, CF.sub.3O,
CF.sub.3), (M-10751, CH.sub.3, F, H, CF.sub.3O, Br), (M-10752,
CH.sub.3, F, H, CF.sub.3O, CH.sub.3), (M-10753, CH.sub.3, F, H, Ph,
H), (M-10754, CH.sub.3, F, H, Ph, Cl), (M-10755, CH.sub.3, F, H,
Ph, F), (M-10756, CH.sub.3, F, H, Ph, CF.sub.3), (M-10757,
CH.sub.3, F, H, Ph, Br), (M-10758, CH.sub.3, F, H, Ph, CH.sub.3),
(M-10759, CH.sub.3, F, H, 4-F-Ph, H), (M-10760, CH.sub.3, F, H,
4-F-Ph, Cl), (M-10761, CH.sub.3, F, H, 4-F-Ph, F), (M-10762,
CH.sub.3, F, H, 4-F-Ph, CF.sub.3), (M-10763, CH.sub.3, F, H,
4-F-Ph, Br), (M-10764, CH.sub.3, F, H, 4-F-Ph, CH.sub.3), (M-10765,
CH.sub.3, F, H, 4-CF.sub.3-Ph, H), (M-10766, CH.sub.3, F, H,
4-CF.sub.3-Ph, Cl), (M-10767, CH.sub.3, F, H, 4-CF.sub.3-Ph, F),
(M-10768, CH.sub.3, F, H, 4-CF.sub.3-Ph, CF.sub.3), (M-10769,
CH.sub.3, F, H, 4-CF.sub.3-Ph, Br), (M-10770, CH.sub.3, F, H,
4-CF.sub.3-Ph, CH.sub.3), (M-10771, CH.sub.3, F, H,
4-(Me).sub.2N-Ph, H), (M-10772, CH.sub.3, F, H, 4-(Me).sub.2N-Ph,
Cl), (M-10773, CH.sub.3, F, H, 4-(Me).sub.2N-Ph, F), (M-10774,
CH.sub.3, F, H, 4-(Me).sub.2N-Ph, CF.sub.3), (M-10775, CH.sub.3, F,
H, 4-(Me).sub.2N-Ph, Br), (M-10776, CH.sub.3, F, H,
4-(Me).sub.2N-Ph, CH.sub.3), (M-10777, CH.sub.3, F, H, 4-OH-Ph, H),
(M-10778, CH.sub.3, F, H, 4-OH-Ph, Cl), (M-10779, CH.sub.3, F, H,
4-OH-Ph, F), (M-10780, CH.sub.3, F, H, 4-OH-Ph, CF.sub.3),
(M-10781, CH.sub.3, F, H, 4-OH-Ph, Br), (M-10782, CH.sub.3, F, H,
4-OH-Ph, CH.sub.3), (M-10783, CH.sub.3, F, H, 3,4-di-F-Ph, H),
(M-10784, CH.sub.3, F, H, 3,4-di-F-Ph, Cl), (M-10785, CH.sub.3, F,
H, 3,4-di-F-Ph, F), (M-10786, CH.sub.3, F, H, 3,4-di-F-Ph,
CF.sub.3), (M-10787, CH.sub.3, F, H, 3,4-di-F-Ph, Br), (M-10788,
CH.sub.3, F, H, 3,4-di-F-Ph, CH.sub.3), (M-10789, CH.sub.3, F, H,
4-COOH-Ph, H), (M-10790, CH.sub.3, F, H, 4-COOH-Ph, Cl), (M-10791,
CH.sub.3, F, H, 4-COOH-Ph, F), (M-10792, CH.sub.3, F, H, 4-COOH-Ph,
CF.sub.3), (M-10793, CH.sub.3, F, H, 4-COOH-Ph, Br), (M-10794,
CH.sub.3, F, H, 4-COOH-Ph, CH.sub.3), (M-10795, CH.sub.3, F, H, Bn,
H), (M-10796, CH.sub.3, F, H, Bn, Cl), (M-10797, CH.sub.3, F, H,
Bn, F), (M-10798, CH.sub.3, F, H, Bn, CF.sub.3), (M-10799,
CH.sub.3, F, H, Bn, Br), (M-10800, CH.sub.3, F, H, Bn, CH.sub.3),
(M-10801, CH.sub.3, F, H, 4-F-Bn, H), (M-10802, CH.sub.3, F, H,
4-F-Bn, Cl), (M-10803, CH.sub.3, F, H, 4-F-Bn, F), (M-10804,
CH.sub.3, F, H, 4-F-Bn, CF.sub.3), (M-10805, CH.sub.3, F, H,
4-F-Bn, Br), (M-10806, CH.sub.3, F, H, 4-F-Bn, CH.sub.3), (M-10807,
CH.sub.3, F, H, 2-Py, H), (M-10808, CH.sub.3, F, H, 2-Py, Cl),
(M-10809, CH.sub.3, F, H, 2-Py, F), (M-10810, CH.sub.3, F, H, 2-Py,
CF.sub.3), (M-10811, CH.sub.3, F, H, 2-Py, Br), (M-10812, CH.sub.3,
F, H, 2-Py, CH.sub.3), (M-10813, CH.sub.3, F, H, 3-Py, H),
(M-10814, CH.sub.3, F, H, 3-Py, Cl), (M-10815, CH.sub.3, F, H,
3-Py, F), (M-10816, CH.sub.3, F, H, 3-Py, CF.sub.3), (M-10817,
CH.sub.3, F, H, 3-Py, Br), (M-10818, CH.sub.3, F, H, 3-Py,
CH.sub.3), (M-10819, CH.sub.3, F, H, 4-Py, H), (M-10820, CH.sub.3,
F, H, 4-Py, Cl), (M-10821, CH.sub.3, F, H, 4-Py, F), (M-10822,
CH.sub.3, F, H, 4-Py, CF.sub.3), (M-10823, CH.sub.3, F, H, 4-Py,
Br), (M-10824, CH.sub.3, F, H, 4-Py, CH.sub.3), (M-10825, CH.sub.3,
F, H, 2-Th, H), (M-10826, CH.sub.3, F, H, 2-Th, Cl), (M-10827,
CH.sub.3, F, H, 2-Th, F), (M-10828, CH.sub.3, F, H, 2-Th,
CF.sub.3), (M-10829, CH.sub.3, F, H, 2-Th, Br), (M-10830, CH.sub.3,
F, H, 2-Th, CH.sub.3), (M-10831, CH.sub.3, F, H, 3-Th, H),
(M-10832, CH.sub.3, F, H, 3-Th, Cl), (M-10833, CH.sub.3, F, H,
3-Th, F), (M-10834, CH.sub.3, F, H, 3-Th, CF.sub.3), (M-10835,
CH.sub.3, F, H, 3-Th, Br), (M-10836, CH.sub.3, F, H, 3-Th,
CH.sub.3), (M-10837, CH.sub.3, F, H, pyrrazol-2-yl, H), (M-10838,
CH.sub.3, F, H, pyrrazol-2-yl, Cl), (M-10839, CH.sub.3, F, H,
pyrrazol-2-yl, F), (M-10840, CH.sub.3, F, H, pyrrazol-2-yl,
CF.sub.3), (M-10841, CH.sub.3, F, H, pyrrazol-2-yl, Br), (M-10842,
CH.sub.3, F, H, pyrrazol-2-yl, CH.sub.3), (M-10843, CH.sub.3, F, H,
pyrrazol-3-yl, H), (M-10844, CH.sub.3, F, H, pyrrazol-3-yl, Cl),
(M-10845, CH.sub.3, F, H, pyrrazol-3-yl, F), (M-10846, CH.sub.3, F,
H, pyrrazol-3-yl, CF.sub.3), (M-10847, CH.sub.3, F, H,
pyrrazol-3-yl, Br), (M-10848, CH.sub.3, F, H, pyrrazol-3-yl,
CH.sub.3), (M-10849, CH.sub.3, F, H, pyrimidin-2-yl, H), (M-10850,
CH.sub.3, F, H, pyrimidin-2-yl, Cl), (M-10851, CH.sub.3, F, H,
pyrimidin-2-yl, F), (M-10852, CH.sub.3, F, H, pyrimidin-2-yl,
CF.sub.3), (M-10853, CH.sub.3, F, H, pyrimidin-2-yl, Br), (M-10854,
CH.sub.3, F, H, pyrimidin-2-yl, CH.sub.3), (M-10855, CH.sub.3, F,
H, pyrimidin-4-yl, H), (M-10856, CH.sub.3, F, H, pyrimidin-4-yl,
Cl), (M-10857, CH.sub.3, F, H, pyrimidin-4-yl, F), (M-10858,
CH.sub.3, F, H, pyrimidin-4-yl, CF.sub.3), (M-10859, CH.sub.3, F,
H, pyrimidin-4-yl, Br), (M-10860, CH.sub.3, F, H, pyrimidin-4-yl,
CH.sub.3), (M-10861, CH.sub.3, F, H, pyrimidin-5-yl, H), (M-10862,
CH.sub.3, F, H, pyrimidin-5-yl, Cl), (M-10863, CH.sub.3, F, H,
pyrimidin-5-yl, F), (M-10864, CH.sub.3, F, H, pyrimidin-5-yl,
CF.sub.3), (M-10865, CH.sub.3, F, H, pyrimidin-5-yl, Br), (M-10866,
CH.sub.3, F, H, pyrimidin-5-yl, CH.sub.3), (M-10867, CH.sub.3, F,
H, HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-10868, CH.sub.3, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-10869, CH.sub.3, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-10870, CH.sub.3, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-10871, CH.sub.3, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2Br), (M-10872, CH.sub.3, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-10873, CH.sub.3, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-10874, CH.sub.3, F, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-10875, CH.sub.3, F,
H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-10876, CH.sub.3, F,
H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-10877,
CH.sub.3, F, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-10878, CH.sub.3, F, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-10879, CH.sub.3, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-10880,
CH.sub.3, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-10881, CH.sub.3, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.3, F), (M-10882,
CH.sub.3, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-10883, CH.sub.3, F, H,
(Me).sub.3NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2Br), (M-10884,
CH.sub.3, F, H, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-10885, CH.sub.3, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-10886, CH.sub.3, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-10887, CH.sub.3, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-10888, CH.sub.3, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-10889, CH.sub.3, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-10890, CH.sub.3, F, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-10891, CH.sub.3, F, H, MeOCH.sub.2, H), (M-10892, CH.sub.3, F,
H, MeOCH.sub.2, Cl), (M-10893, CH.sub.3, F, H, MeOCH.sub.2, F),
(M-10894, CH.sub.3, F, H, MeOCH.sub.2, CF.sub.3), (M-10895,
CH.sub.3, F, H, MeOCH.sub.2, Br), (M-10896, CH.sub.3, F, H,
MeOCH.sub.2, CH.sub.3), (M-10897, CH.sub.3, F, H, EtOCH.sub.2, H),
(M-10898, CH.sub.3, F, H, EtOCH.sub.2, Cl), (M-10899, CH.sub.3, F,
H, EtOCH.sub.2, F), (M-10900, CH.sub.3, F, H, EtOCH.sub.2,
CF.sub.3), (M-10901, CH.sub.3, F, H, EtOCH.sub.2, Br), (M-10902,
CH.sub.3, F, H, EtOCH.sub.2, CH.sub.3), (M-10903, CH.sub.3, F, H,
EtOCH.sub.2CH.sub.2, H), (M-10904, CH.sub.3, F, H,
EtOCH.sub.2CH.sub.2, Cl), (M-10905, CH.sub.3, F, H,
EtOCH.sub.2CH.sub.2, F), (M-10906, CH.sub.3, F, H,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-10907, CH.sub.3, F, H,
EtOCH.sub.2CH.sub.2, Br), (M-10908, CH.sub.3, F, H,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-10909, CH.sub.3, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-10910, CH.sub.3, F, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-10911, CH.sub.3, F,
H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-10912, CH.sub.3, F,
H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-10913,
CH.sub.3, F, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-10914, CH.sub.3, F, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-10915, CH.sub.3, F, H, MeOCH.sub.2CH.sub.2, H),
(M-10916, CH.sub.3, F, H, MeOCH.sub.2CH.sub.2, Cl), (M-10917,
CH.sub.3, F, H, MeOCH.sub.2CH.sub.2, F), (M-10918, CH.sub.3, F, H,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-10919, CH.sub.3, F, H,
MeOCH.sub.2CH.sub.2, Br), (M-10920, CH.sub.3, F, H,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-10921, CH.sub.3, F, H,
HOCH.sub.2, H), (M-10922, CH.sub.3, F, H, HOCH.sub.2, Cl),
(M-10923, CH.sub.3, F, H, HOCH.sub.2, F), (M-10924, CH.sub.3, F, H,
HOCH.sub.2, CF.sub.3), (M-10925, CH.sub.3, F, H, HOCH.sub.2, Br),
(M-10926, CH.sub.3, F, H, HOCH.sub.2, CH.sub.3), (M-10927,
CH.sub.3, F, H, HOCH.sub.2CH.sub.2, H), (M-10928, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2, Cl), (M-10929, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2, F), (M-10930, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-10931, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2, Br), (M-10932, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-10933, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-10934, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-10935, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-10936, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-10937, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-10938, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-10939, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-10940, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-10941, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-10942, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-10943, CH.sub.3,
F, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-10944, CH.sub.3,
F, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-10945,
CH.sub.3, F, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H),
(M-10946, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-10947, CH.sub.3,
F, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-10948,
CH.sub.3, F, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-10949, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-10950,
CH.sub.3, F, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-10951, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-10952, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-10953, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-10954, CH.sub.3, F, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-10955, CH.sub.3,
F, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-10956, CH.sub.3,
F, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-10957,
CH.sub.3, F, H, (Me).sub.2N, H), (M-10958, CH.sub.3, F, H,
(Me).sub.2N, Cl), (M-10959, CH.sub.3, F, H, (Me).sub.2N, F),
(M-10960, CH.sub.3, F, H, (Me).sub.2N, CF.sub.3), (M-10961,
CH.sub.3, F, H, (Me).sub.2N, Br), (M-10962, CH.sub.3, F, H,
(Me).sub.2N, CH.sub.3), (M-10963, CH.sub.3, F, H,
piperidin-4-yl-methyl, H), (M-10964, CH.sub.3, F, H,
piperidin-4-yl-methyl, Cl), (M-10965, CH.sub.3, F, H,
piperidin-4-yl-methyl, F), (M-10966, CH.sub.3, F, H,
piperidin-4-yl-methyl, CF.sub.3), (M-10967, CH.sub.3, F, H,
piperidin-4-yl-methyl, Br), (M-10968, CH.sub.3, F, Ft,
piperidin-4-yl-methyl, CH.sub.3), (M-10969, CH.sub.3, F, H,
cyclohexylmethyl, H), (M-10970, CH.sub.3, F, H, cyclohexylmethyl,
Cl), (M-10971, CH.sub.3, F, H, cyclohexylmethyl, F), (M-10972,
CH.sub.3, F, H, cyclohexylmethyl, CF.sub.3), (M-10973, CH.sub.3, F,
H, cyclohexylmethyl, Br), (M-10974, CH.sub.3, F, H,
cyclohexylmethyl, CH.sub.3), (M-10975, CH.sub.3, F, F, H, H),
(M-10976, CH.sub.3, F, F, H, Cl), (M-10977, CH.sub.3, F, F, H, F),
(M-10978, CH.sub.3, F, F, H, CF.sub.3), (M-10979, CH.sub.3, F, F,
H, Br), (M-10980, CH.sub.3, F, F, H, CH.sub.3), (M-10981, CH.sub.3,
F, F, F, H), (M-10982, CH.sub.3, F, F, F, Cl), (M-10983, CH.sub.3,
F, F, F, F), (M-10984, CH.sub.3, F, F, F, CF.sub.3), (M-10985,
CH.sub.3, F, F, F, Br), (M-10986, CH.sub.3, F, F, F, CH.sub.3),
(M-10987, CH.sub.3, F, F, Cl, H), (M-10988, CH.sub.3, F, F, Cl,
Cl), (M-10989, CH.sub.3, F, F, Cl, F), (M-10990, CH.sub.3, F, F,
Cl, CF.sub.3), (M-10991, CH.sub.3, F, F, Cl, Br), (M-10992,
CH.sub.3, F, F, Cl, CH.sub.3), (M-10993, CH.sub.3, F, F, CH.sub.3,
H), (M-10994, CH.sub.3, F, F, CH.sub.3, Cl), (M-10995, CH.sub.3, F,
F, CH.sub.3, F), (M-10996, CH.sub.3, F, F, CH.sub.3, CF.sub.3),
(M-10997, CH.sub.3, F, F, CH.sub.3, Br), (M-10998, CH.sub.3, F, F,
CH.sub.3, CH.sub.3), (M-10999, CH.sub.3, F, F, Et, H), (M-11000,
CH.sub.3, F, F, Et, Cl), (M-11001, CH.sub.3, F, F, Et, F),
(M-11002, CH.sub.3, F, F, Et, CF.sub.3), (M-11003, CH.sub.3, F, F,
Et, Br), (M-11004, CH.sub.3, F, F, Et, CH.sub.3), (M-11005,
CH.sub.3, F, F, n-Pr, H), (M-11006, CH.sub.3, F, F, n-Pr, Cl),
(M-11007, CH.sub.3, F, F, n-Pr, F), (M-11008, CH.sub.3, F, F, n-Pr,
CF.sub.3), (M-11009, CH.sub.3, F, F, n-Pr, Br), (M-11010, CH.sub.3,
F, F, n-Pr, CH.sub.3), (M-11011, CH.sub.3, F, F, c-Pr, H),
(M-11012, CH.sub.3, F, F, c-Pr, Cl), (M-11013, CH.sub.3, F, F,
c-Pr, F), (M-11014, CH.sub.3, F, F, c-Pr, CF.sub.3), (M-11015,
CH.sub.3, F, F, c-Pr, Br), (M-11016, CH.sub.3, F, F, c-Pr,
CH.sub.3), (M-11017, CH.sub.3, F, F, i-Pr, H), (M-11018, CH.sub.3,
F, F, i-Pr, Cl), (M-11019, CH.sub.3, F, F, i-Pr, F), (M-11020,
CH.sub.3, F, F, i-Pr, CF.sub.3), (M-11021, CH.sub.3, F, F, i-Pr,
Br), (M-11022, CH.sub.3, F, F, i-Pr, CH.sub.3), (M-11023, CH.sub.3,
F, F, n-Bu, H), (M-11024, CH.sub.3, F, F, n-Bu, Cl), (M-11025,
CH.sub.3, F, F, n-Bu, F), (M-11026, CH
.sub.3, F, F, n-Bu, CF.sub.3), (M-11027, CH.sub.3, F, F, n-Bu, Br),
(M-11028, CH.sub.3, F, F, n-Bu, CH.sub.3), (M-11029, CH.sub.3, F,
F, i-Bu, H), (M-11030, CH.sub.3, F, F, i-Bu, Cl), (M-11031,
CH.sub.3, F, F, i-Bu, F), (M-11032, CH.sub.3, F, F, i-Bu,
CF.sub.3), (M-11033, CH.sub.3, F, F, i-Bu, Br), (M-11034, CH.sub.3,
F, F, i-Bu, CH.sub.3), (M-11035, CH.sub.3, F, F, sec-Bu, H),
(M-11036, CH.sub.3, F, F, sec-Bu, Cl), (M-11037, CH.sub.3, F, F,
sec-Bu, F), (M-11038, CH.sub.3, F, F, sec-Bu, CF.sub.3), (M-11039,
CH.sub.3, F, F, sec-Bu, Br), (M-11040, CH.sub.3, F, F, sec-Bu,
CH.sub.3), (M-11041, CH.sub.3, F, F, n-Pen, H), (M-11042, CH.sub.3,
F, F, n-Pen, Cl), (M-11043, CH.sub.3, F, F, n-Pen, F), (M-11044,
CH.sub.3, F, F, n-Pen, CF.sub.3), (M-11045, CH.sub.3, F, F, n-Pen,
Br), (M-11046, CH.sub.3, F, F, n-Pen, CH.sub.3), (M-11047,
CH.sub.3, F, F, c-Pen, H), (M-11048, CH.sub.3, F, F, c-Pen, Cl),
(M-11049, CH.sub.3, F, F, c-Pen, F), (M-11050, CH.sub.3, F, F,
c-Pen, CF.sub.3), (M-11051, CH.sub.3, F, F, c-Pen, Br), (M-11052,
CH.sub.3, F, F, c-Pen, CH.sub.3), (M-11053, CH.sub.3, F, F, n-Hex,
H), (M-11054, CH.sub.3, F, F, n-Hex, Cl), (M-11055, CH.sub.3, F, F,
n-Hex, F), (M-11056, CH.sub.3, F, F, n-Hex, CF.sub.3), (M-11057,
CH.sub.3, F, F, n-Hex, Br), (M-11058, CH.sub.3, F, F, n-Hex,
CH.sub.3), (M-11059, CH.sub.3, F, F, c-Hex, H), (M-11060, CH.sub.3,
F, F, c-Hex, Cl), (M-11061, CH.sub.3, F, F, c-Hex, F), (M-11062,
CH.sub.3, F, F, c-Hex, CF.sub.3), (M-11063, CH.sub.3, F, F, c-Hex,
Br), (M-11064, CH.sub.3, F, F, c-Hex, CH.sub.3), (M-11065,
CH.sub.3, F, F, OH, H), (M-11066, CH.sub.3, F, F, OH, Cl),
(M-11067, CH.sub.3, F, F, OH, F), (M-11068, CH.sub.3, F, F, OH,
CF.sub.3), (M-11069, CH.sub.3, F, F, OH, Br), (M-11070, CH.sub.3,
F, F, OH, CH.sub.3), (M-11071, CH.sub.3, F, F, EtO, H), (M-11072,
CH.sub.3, F, F, EtO, Cl), (M-11073, CH.sub.3, F, F, EtO, F),
(M-11074, CH.sub.3, F, F, EtO, CF.sub.3), (M-11075, CH.sub.3, F, F,
EtO, Br), (M-11076, CH.sub.3, F, F, EtO, CH.sub.3), (M-11077,
CH.sub.3, F, F, n-PrO, H), (M-11078, CH.sub.3, F, F, n-PrO, Cl),
(M-11079, CH.sub.3, F, F, n-PrO, F), (M-11080, CH.sub.3, F, F,
n-PrO, CF.sub.3), (M-11081, CH.sub.3, F, F, n-PrO, Br), (M-11082,
CH.sub.3, F, F, n-PrO, CH.sub.3), (M-11083, CH.sub.3, F, F, PhO,
H), (M-11084, CH.sub.3, F, F, PhO, Cl), (M-11085, CH.sub.3, F, F,
PhO, F), (M-11086, CH.sub.3, F, F, PhO, CF.sub.3), (M-11087,
CH.sub.3, F, F, PhO, Br), (M-11088, CH.sub.3, F, F, PhO, CH.sub.3),
(M-11089, CH.sub.3, F, F, BnO, H), (M-11090, CH.sub.3, F, F, BnO,
Cl), (M-11091, CH.sub.3, F, F, BnO, F), (M-11092, CH.sub.3, F, F,
BnO, CF.sub.3), (M-11093, CH.sub.3, F, F, BnO, Br), (M-11094,
CH.sub.3, F, F, BnO, CH.sub.3), (M-11095, CH.sub.3, F, F,
PhCH.sub.2CH.sub.2O, H), (M-11096, CH.sub.3, F, F,
PhCH.sub.2CH.sub.2O, Cl), (M-11097, CH.sub.3, F, F,
PhCH.sub.2CH.sub.2O, F), (M-11098, CH.sub.3, F, F,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-11099, CH.sub.3, F, F,
PhCH.sub.2CH.sub.2O, Br), (M-11100, CH.sub.3, F, F,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-11101, CH.sub.3, F, F,
CF.sub.3O, H), (M-11102, CH.sub.3, F, F, CF.sub.3O, Cl), (M-11103,
CH.sub.3, F, F, CF.sub.3O, F), (M-11104, CH.sub.3, F, F, CF.sub.3O,
CH.sub.3), (M-11105, CH.sub.3, F, F, CF.sub.3O, Br), (M-11106,
CH.sub.3, F, F, CF.sub.3O, CH.sub.3), (M-11107, CH.sub.3, F, F, Ph,
H), (M-11108, CH.sub.3, F, F, Ph, Cl), (M-11109, CH.sub.3, F, F,
Ph, F), (M-11110, CH.sub.3, F, F, Ph, CF.sub.3), (M-11111,
CH.sub.3, F, F, Ph, Br), (M-11112, CH.sub.3, F, F, Ph, CH.sub.3),
(M-11113, CH.sub.3, F, F, 4-F-Ph, H), (M-11114, CH.sub.3, F, F,
4-F-Ph, Cl), (M-11115, CH.sub.3, F, F, 4-F-Ph, F), (M-11116, CPIs,
F, F, 4-F-Ph, CF.sub.3), (M-11117, CH.sub.3, F, F, 4-F-Ph, Br),
(M-11118, CH.sub.3, F, F, 4-F-Ph, CH.sub.3), (M-11119, CH.sub.3, F,
F, 4-CF.sub.3-Ph, H), (M-11120, CH.sub.3, F, F, 4-CF.sub.3-Ph, Cl),
(M-11121, CH.sub.3, F, F, 4-CF.sub.3-Ph, F), (M-11122, CH.sub.3, F,
F, 4-CF.sub.3-Ph, CF.sub.3), (M-11123, CH.sub.3, F, F,
4-CF.sub.3-Ph, Br), (M-11124, CH.sub.3, F, F, 4-CF.sub.3-Ph,
CH.sub.3), (M-11125, CH.sub.3, F, F, 4-(Me).sub.2N-Ph, H),
(M-11126, CH.sub.3, F, F, 4-(Me).sub.2N-Ph, Cl), (M-11127,
CH.sub.3, F, F, 4-(Me).sub.2N-Ph, F), (M-11128, CH.sub.3, F, F,
4-(Me).sub.2N-Ph, CF.sub.3), (M-11129, CH.sub.3, F, F,
4-(Me).sub.2N-Ph, Br), (M-11130, CH.sub.3, F, F, 4-(Me).sub.2N-Ph,
CH.sub.3), (M-11131, CH.sub.3, F, F, 4-OH-Ph, H), (M-11132,
CH.sub.3, F, F, 4-OH-Ph, Cl), (M-11133, CH.sub.3, F, F, 4-OH-Ph,
F), (M-11134, CH.sub.3, F, F, 4-OH-Ph, CF.sub.3), (M-11135,
CH.sub.3, F, F, 4-OH-Ph, Br), (M-11136, CH.sub.3, F, F, 4-OH-Ph,
CH.sub.3), (M-11137, CH.sub.3, F, F, 3,4-di-F-Ph, H), (M-11138,
CH.sub.3, F, F, 3,4-di-F-Ph, Cl), (M-11139, CH.sub.3, F, F,
3,4-di-F-Ph, F), (M-11140, CH.sub.3, F, F, 3,4-di-F-Ph, CF.sub.3),
(M-11141, CH.sub.3, F, F, 3,4-di-F-Ph, Br), (M-11142, CH.sub.3, F,
F, 3,4-di-F-Ph, CH.sub.3), (M-11143, CH.sub.3, F, F, 4-COOH-Ph, H),
(M-11144, CH.sub.3, F, F, 4-COOH-Ph, Cl), (M-11145, CH.sub.3, F, F,
4-COOH-Ph, F), (M-11146, CH.sub.3, F, F, 4-COOH-Ph, CF.sub.3),
(M-11147, CH.sub.3, F, F, 4-COOH-Ph, Br), (M-11148, CH.sub.3, F, F,
4-COOH-Ph, CH.sub.3), (M-11149, CH.sub.3, F, F, Bn, H), (M-11150,
CH.sub.3, F, F, Bn, Cl), (M-11151, CH.sub.3, F, F, Bn, F),
(M-11152, CH.sub.3, F, F, Bn, CF.sub.3), (M-11153, CH.sub.3, F, F,
Bn, Br), (M-11154, CH.sub.3, F, F, Bn, CH.sub.3), (M-11155,
CH.sub.3, F, F, 4-F-Bn, H), (M-11156, CH.sub.3, F, F, 4-F-Bn, Cl),
(M-11157, CH.sub.3, F, F, 4-F-Bn, F), (M-11158, CH.sub.3, F, F,
4-F-Bn, CF.sub.3), (M-11159, CH.sub.3, F, F, 4-F-Bn, Br), (M-11160,
CH.sub.3, F, F, 4-F-Bn, CH.sub.3), (M-11161, CH.sub.3, F, F, 2-Py,
H), (M-11162, CH.sub.3, F, F, 2-Py, Cl), (M-11163, CH.sub.3, F, F,
2-Py, F), (M-11164, CH.sub.3, F, F, 2-Py, CF.sub.3), (M-11165,
CH.sub.3, F, F, 2-Py, Br), (M-11166, CH.sub.3, F, F, 2-Py,
CH.sub.3), (M-11167, CH.sub.3, F, F, 3-Py, H), (M-11168, CH.sub.3,
F, F, 3-Py, Cl), (M-11169, CH.sub.3, F, F, 3-Py, F), (M-11170,
CH.sub.3, F, F, 3-Py, CF.sub.3), (M-11171, CH.sub.3, F, F, 3-Py,
Br), (M-11172, CH.sub.3, F, F, 3-Py, CH.sub.3), (M-11173, CH.sub.3,
F, F, 4-Py, H), (M-11174, CH.sub.3, F, F, 4-Py, Cl), (M-11175,
CH.sub.3, F, F, 4-Py, F), (M-11176, CH.sub.3, F, F, 4-Py,
CF.sub.3), (M-11177, CH.sub.3, F, F, 4-Py, Br), (M-11178, CH.sub.3,
F, F, 4-Py, CH.sub.3), (M-11179, CH.sub.3, F, F, 2-Th, H),
(M-11180, CH.sub.3, F, F, 2-Th, Cl), (M-11181, CH.sub.3, F, F,
2-Th, F), (M-11182, CH.sub.3, F, F, 2-Th, CF.sub.3), (M-11183,
CH.sub.3, F, F, 2-Th, Br), (M-11184, CH.sub.3, F, F, 2-Th,
CH.sub.3), (M-11185, CH.sub.3, F, F, 3-Th, H), (M-11186, CH.sub.3,
F, F, 3-Th, Cl), (M-11187, CH.sub.3, F, F, 3-Th, F), (M-11188,
CH.sub.3, F, F, 3-Th, CF.sub.3), (M-11189, CH.sub.3, F, F, 3-Th,
Br), (M-11190, CH.sub.3, F, F, 3-Th, CH.sub.3), (M-11191, CH.sub.3,
F, F, pyrrazol-2-yl, H), (M-11192, CH.sub.3, F, F, pyrrazol-2-yl,
Cl), (M-11193, CH.sub.3, F, F, pyrrazol-2-yl, F), (M-11194,
CH.sub.3, F, F, pyrrazol-2-yl, CF.sub.3), (M-11195, CH.sub.3, F, F,
pyrrazol-2-yl, Br), (M-11196, CH.sub.3, F, F, pyrrazol-2-yl,
CH.sub.3), (M-11197, CH.sub.3, F, F, pyrrazol-3-yl, H), (M-11198,
CH.sub.3, F, F, pyrrazol-3-yl, Cl), (M-11199, CH.sub.3, F, F,
pyrrazol-3-yl, F), (M-11200, CH.sub.3, F, F, pyrrazol-3-yl,
CF.sub.3), (M-11201, CH.sub.3, F, F, pyrrazol-3-yl, Br), (M-11202,
CH.sub.3, F, F, pyrrazol-3-yl, CH.sub.3), (M-11203, CH.sub.3, F, F,
pyrimidin-2-yl, H), (M-11204, CH.sub.3, F, F, pyrimidin-2-yl, Cl),
(M-11205, CH.sub.3, F, F, pyrimidin-2-yl, F), (M-11206, CH.sub.3,
F, F, pyrimidin-2-yl, CF.sub.3), (M-11207, CH.sub.3, F, F,
pyrimidin-2-yl, Br), (M-11208, CH.sub.3, F, F, pyrimidin-2-yl,
CH.sub.3), (M-11209, CH.sub.3, F, F, pyrimidin-4-yl, H), (M-11210,
CH.sub.3, F, F, pyrimidin-4-yl, Cl), (M-11211, CH.sub.3, F, F,
pyrimidin-4-yl, F), (M-11212, CH.sub.3, F, F, pyrimidin-4-yl,
CF.sub.3), (M-11213, CH.sub.3, F, F, pyrimidin-4-yl, Br), (M-11214,
CH.sub.3, F, F, pyrimidin-4-yl, CH.sub.3), (M-11215, CH.sub.3, F,
F, pyrimidin-5-yl, H), (M-11216, CH.sub.3, F, F, pyrimidin-5-yl,
Cl), (M-11217, CH.sub.3, F, F, pyrimidin-5-yl, F), (M-11218,
CH.sub.3, F, F, pyrimidin-5-yl, CF.sub.3), (M-11219, CH.sub.3, F,
F, pyrimidin-5-yl, Br), (M-11220, CH.sub.3, F, F, pyrimidin-5-yl,
CH.sub.3), (M-11221, CH.sub.3, F, F, HOOCCH.sub.2CH.sub.2CH.sub.2,
H), (M-11222, CH.sub.3, F, F, HOOCCH.sub.26H.sub.2CH.sub.2, Cl),
(M-11223, CH.sub.3, F, F, HOOCCH.sub.2CH.sub.2CH.sub.2, F),
(M-11224, CH.sub.3, F, F, HOOCCH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-11225, CH.sub.3, F, F, HOOCCH.sub.2CH.sub.2CH.sub.2, Br),
(M-11226, CH.sub.3, F, F, HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-11227, CH.sub.3, F, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-11228, CH.sub.3, F, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Cl), (M-11229, CH.sub.3, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-11230, CH.sub.3, F, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-11231,
CH.sub.3, F, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-11232, CH.sub.3, F, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-11233, CH.sub.3, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-11234,
CH.sub.3, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-11235, CH.sub.3, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-11236,
CH.sub.3, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-11237, CH.sub.3, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-11238,
CH.sub.3, F, F, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-11239, CH.sub.3, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-11240, CH.sub.3, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-11241,
CH.sub.3, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-11242, CH.sub.3, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-11243, CH.sub.3, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-11244, CH.sub.3, F, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-11245, CH.sub.3, F, F, MeOCH.sub.2, H), (M-11246, CH.sub.3, F,
F, MeOCH.sub.2, Cl), (M-11247, CH.sub.3, F, F, MeOCH.sub.2, F),
(M-11248, CH.sub.3, F, F, MeOCH.sub.2, CF.sub.3), (M-11249,
CH.sub.3, F, F, MeOCH.sub.2, Br), (M-11250, CH.sub.3, F, F,
MeOCH.sub.2, CH.sub.3), (M-11251, CH.sub.3, F, F, EtOCH.sub.2, H),
(M-11252, CH.sub.3, F, F, EtOCH.sub.2, Cl), (M-11253, CH.sub.3, F,
F, EtOCH.sub.2, F), (M-11254, CH.sub.3, F, F, EtOCH.sub.2,
CF.sub.3), (M-11255, CH.sub.3, F, F, EtOCH.sub.2, Br), (M-11256,
CH.sub.3, F, F, EtOCH.sub.2, CH.sub.3), (M-11257, CH.sub.3, F, F,
EtOCH.sub.2CH.sub.2, H), (M-11258, CH.sub.3, F, F,
EtOCH.sub.2CH.sub.2, Cl), (M-11259, CH.sub.3, F, F,
EtOCH.sub.2CH.sub.2, F), (M-11260, CH.sub.3, F, F,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-11261, CH.sub.3, F, F,
EtOCH.sub.2CH.sub.2, Br), (M-11262, CH.sub.3, F, F,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-11263, CH.sub.3, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-11264, CH.sub.3, F, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-11265, CH.sub.3, F,
F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-11266, CH.sub.3, F,
F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-11267,
CH.sub.3, F, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-11268, CH.sub.3, F, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-11269, CH.sub.3, F, F, MeOCH.sub.2CH.sub.2, H),
(M-11270, CH.sub.3, F, F, MeOCH.sub.2CH.sub.2, Cl), (M-11271,
CH.sub.3, F, F, MeOCH.sub.2CH.sub.2, F), (M-11272, CH.sub.3, F, F,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-11273, CH.sub.3, F, F,
MeOCH.sub.2CH.sub.2, Br), (M-11274, CH.sub.3, F, F,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-11275, CH.sub.3, F, F,
HOCH.sub.2, H), (M-11276, CH.sub.3, F, F, HOCH.sub.2, Cl),
(M-11277, CH.sub.3, F, F, HOCH.sub.2, F), (M-11278, CH.sub.3, F, F,
HOCH.sub.2, CF.sub.3), (M-11279, CH.sub.3, F, F, HOCH.sub.2, Br),
(M-11280, CH.sub.3, F, F, HOCH.sub.2, CH.sub.3), (M-11281,
CH.sub.3, F, F, HOCH.sub.2CH.sub.2, H), (M-11282, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2, Cl), (M-11283, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2, F), (M-11284, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-11286, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2, Br), (M-11286, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-11287, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-11288, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-11289, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-11290, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-11291, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-11292, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-11293, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-11294, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-11295, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-11296, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-11297, CH.sub.3,
F, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-11298, CH.sub.3,
F, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-11299,
CH.sub.3, F, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H),
(M-11300, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-11301,
CH.sub.3, F, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-11302, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3), (M-11303,
CH.sub.3, F, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Br),
(M-11304, CH.sub.3, F, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-11306,
CH.sub.3, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-11306,
CH.sub.3, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-11307,
CH.sub.3, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-11308,
CH.sub.3, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-11309, CH.sub.3, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-11310, CH.sub.3, F, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-11311, CH.sub.3, F, F, (Me).sub.2N, H), (M-11312,
CH.sub.3, F, F, (Me).sub.2N, Cl), (M-11313, CH.sub.3, F, F,
(Me).sub.2N, F), (M-11314, CH.sub.3, F, F, (Me).sub.2N, CF.sub.3),
(M-11315, CH.sub.3, F, F, (Me).sub.2N, Br), (M-11316, CH.sub.3, F,
F, (Me).sub.2N, CH.sub.3), (M-11317, CH.sub.3, F, F,
piperidin-4-yl-methyl, H), (M-11318, CH.sub.3, F, F,
piperidin-4-yl-methyl, Cl), (M-11319, CH.sub.3, F, F,
piperidin-4-yl-methyl, F), (M-11320, CH.sub.3, F, F,
piperidin-4-yl-methyl, CF.sub.3), (M-11321, CH.sub.3, F, F,
piperidin-4-yl-methyl, Br), (M-11322, CH.sub.3, F, F,
piperidin-4-yl-methyl, CH.sub.3), (M-11323, CH.sub.3, F, F,
cyclohexylmethyl, H), (M-11324, CH.sub.3, F, F, cyclohexylmethyl,
Cl), (M-11325, CH.sub.3, F, F, cyclohexylmethyl, F), (M-11326,
CH.sub.3, F, F, cyclohexylmethyl, CF.sub.3), (M-11327, CH.sub.3, F,
F, cyclohexylmethyl, Br), (M-11328, CH.sub.3, F, F,
cyclohexylmethyl, CH.sub.3), (M-11329, CH.sub.3, F, Cl, H, H),
(M-11330, CH.sub.3, F, Cl, H, Cl), (M-11331, CH.sub.3, F, Cl, H,
F), (M-11332, CH.sub.3, F, Cl, H, CF.sub.3), (M-11333, CH.sub.3, F,
Cl, H, Br), (M-11334, CH.sub.3, F, Cl, H, CH.sub.3), (M-11335,
CH.sub.3, F, Cl, F, H), (M-11336, CH.sub.3, F, Cl, F, Cl),
(M-11337, CH
.sub.3, F, Cl, F, F), (M-11338, CH.sub.3, F, Cl, F, CF.sub.3),
(M-11339, CH.sub.3, F, Cl, F, Br), (M-11340, CH.sub.3, F, Cl, F,
CH.sub.3), (M-11341, CH.sub.3, F, Cl, Cl, H), (M-11342, CH.sub.3,
F, Cl, Cl, Cl), (M-11343, CH.sub.3, F, Cl, Cl, F), (M-11344,
CH.sub.3, F, Cl, Cl, CF.sub.3), (M-11345, CH.sub.3, F, Cl, Cl, Br),
(M-11346, CH.sub.3, F, Cl, Cl, CH.sub.3), (M-11347, CH.sub.3, F,
Cl, CH.sub.3, H), (M-11348, CH.sub.3, F, Cl, CH.sub.3, Cl),
(M-11349, CH.sub.3, F, Cl, CH.sub.3, F), (M-11350, CH.sub.3, F, Cl,
CH.sub.3, CF.sub.3), (M-11351, CH.sub.3, F, Cl, CH.sub.3, Br),
(M-11352, CH.sub.3, F, Cl, CH.sub.3, CH.sub.3), (M-11353, CH.sub.3,
F, Cl, Et, H), (M-11354, CH.sub.3, F, Cl, Et, Cl), (M-11355,
CH.sub.3, F, Cl, Et, F), (M-11356, CH.sub.3, F, Cl, Et, CF.sub.3),
(M-11357, CH.sub.3, F, Cl, Et, Br), (M-11358, CH.sub.3, F, Cl, Et,
CH.sub.3), (M-11359, CH.sub.3, F, Cl, n-Pr, H), (M-11360, CH.sub.3,
F, Cl, n-Pr, Cl), (M-11361, CH.sub.3, F, Cl, n-Pr, F), (M-11362,
CH.sub.3, F, Cl, n-Pr, CF.sub.3), (M-11363, CH.sub.3, F, Cl, n-Pr,
Br), (M-11364, CH.sub.3, F, Cl, n-Pr, CH.sub.3), (M-11365,
CH.sub.3, F, Cl, c-Pr, H), (M-11366, CH.sub.3, F, Cl, c-Pr, Cl),
(M-11367, CH.sub.3, F, Cl, c-Pr, F), (M-11368, CH.sub.3, F, Cl,
c-Pr, CF.sub.3), (M-11369, CH.sub.3, F, Cl, c-Pr, Br), (M-11370,
CH.sub.3, F, Cl, c-Pr, CH.sub.3), (M-11371, CH.sub.3, F, Cl, i-Pr,
H), (M-11372, CH.sub.3, F, Cl, i-Pr, Cl), (M-11373, CH.sub.3, F,
Cl, i-Pr, F), (M-11374, CH.sub.3, F, Cl, i-Pr, CF.sub.3), (M-11375,
CH.sub.3, F, Cl, i-Pr, Br), (M-11376, CH.sub.3, F, Cl, i-Pr,
CH.sub.3), (M-11377, CH.sub.3, F, Cl, n-Bu, H), (M-11378, CH.sub.3,
F, Cl, n-Bu, Cl), (M-11379, CH.sub.3, F, Cl, n-Bu, F), (M-11380,
CH.sub.3, F, Cl, n-Bu, CF.sub.3), (M-11381, CH.sub.3, F, Cl, n-Bu,
Br), (M-11382, CH.sub.3, F, Cl, n-Bu, CH.sub.3), (M-11383,
CH.sub.3, F, Cl, i-Bu, H), (M-11384, CH.sub.3, F, Cl, i-Bu, Cl),
(M-11385, CH.sub.3, F, Cl, i-Bu, F), (M-11386, CH.sub.3, F, Cl,
i-Bu, CF.sub.3), (M-11387, CH.sub.3, F, Cl, i-Bu, Br), (M-11388,
CH.sub.3, F, Cl, i-Bu, CH.sub.3), (M-11389, CH.sub.3, F, Cl,
sec-Bu, H), (M-11390, CH.sub.3, F, Cl, sec-Bu, Cl), (M-11391,
CH.sub.3, F, Cl, sec-Bu, F), (M-11392, CH.sub.3, F, Cl, sec-Bu,
CF.sub.3), (M-11393, CH.sub.3, F, Cl, sec-Bu, Br), (M-11394,
CH.sub.3, F, Cl, sec-Bu, CH.sub.3), (M-11395, CH.sub.3, F, Cl,
n-Pen, H), (M-11396, CH.sub.3, F, Cl, n-Pen, Cl), (M-11397,
CH.sub.3, F, Cl, n-Pen, F), (M-11398, CH.sub.3, F, Cl, n-Pen,
CF.sub.3), (M-11399, CH.sub.3, F, Cl, n-Pen, Br), (M-11400,
CH.sub.3, F, Cl, n-Pen, CH.sub.3), (M-11401, CH.sub.3, F, Cl,
c-Pen, H), (M-11402, CH.sub.3, F, Cl, c-Pen, Cl), (M-11403,
CH.sub.3, F, Cl, c-Pen, F), (M-11404, CH.sub.3, F, Cl, c-Pen,
CF.sub.3), (M-11405, CH.sub.3, F, Cl, c-Pen, Br), (M-11406,
CH.sub.3, F, Cl, c-Pen, CH.sub.3), (M-11407, CH.sub.3, F, Cl,
n-Hex, H), (M-11408, CH.sub.3, F, Cl, n-Hex, Cl), (M-11409,
CH.sub.3, F, Cl, n-Hex, F), (M-11410, CH.sub.3, F, Cl, n-Hex,
CF.sub.3), (M-11411, CH.sub.3, F, Cl, n-Hex, Br), (M-11412,
CH.sub.3, F, Cl, n-Hex, CH.sub.3), (M-11413, CH.sub.3, F, Cl,
c-Hex, H), (M-11414, CH.sub.3, F, Cl, c-Hex, Cl), (M-11415,
CH.sub.3, F, Cl, c-Hex, F), (M-11416, CH.sub.3, F, Cl, c-Hex,
CF.sub.3), (M-11417, CH.sub.3, F, Cl, c-Hex, Br), (M-11418,
CH.sub.3, F, Cl, c-Hex, CH.sub.3), (M-11419, CH.sub.3, F, Cl, OH,
H), (M-11420, CH.sub.3, F, Cl, OH, Cl), (M-11421, CH.sub.3, F, Cl,
OH, F), (M-11422, CH.sub.3, F, Cl, OH, CF.sub.3), (M-11423,
CH.sub.3, F, Cl, OH, Br), (M-11424, CH.sub.3, F, Cl, OH, CH.sub.3),
(M-11425, CH.sub.3, F, Cl, EtO, H), (M-11426, CH.sub.3, F, Cl, EtO,
Cl), (M-11427, CH.sub.3, F, Cl, EtO, F), (M-11428, CH.sub.3, F, Cl,
EtO, CF.sub.3), (M-11429, CH.sub.3, F, Cl, EtO, Br), (M-11430,
CH.sub.3, F, Cl, EtO, CH.sub.3), (M-11431, CH.sub.3, F, Cl, n-PrO,
H), (M-11432, CH.sub.3, F, Cl, n-PrO, Cl), (M-11433, CH.sub.3, F,
Cl, n-PrO, F), (M-11434, CH.sub.3, F, Cl, n-PrO, CF.sub.3),
(M-11435, CH.sub.3, F, Cl, n-PrO, Br), (M-11436, CH.sub.3, F, Cl,
n-PrO, CH.sub.3), (M-11437, CH.sub.3, F, Cl, PhO, H), (M-11438,
CH.sub.3, F, Cl, PhO, Cl), (M-11439, CH.sub.3, F, Cl, PhO, F),
(M-11440, CH.sub.3, F, Cl, PhO, CF.sub.3), (M-11441, CH.sub.3, F,
Cl, PhO, Br), (M-11442, CH.sub.3, F, Cl, PhO, CH.sub.3), (M-11443,
CH.sub.3, F, Cl, BnO, H), (M-11444, CH.sub.3, F, Cl, BnO, Cl),
(M-11445, CH.sub.3, F, Cl, BnO, F), (M-11446, CH.sub.3, F, Cl, BnO,
CF.sub.3), (M-11447, CH.sub.3, F, Cl, BnO, Br), (M-11448, CH.sub.3,
F, Cl, BnO, CH.sub.3), (M-11449, CH.sub.3, F, Cl,
PhCH.sub.2CH.sub.2O, H), (M-11450, CH.sub.3, F, Cl,
PhCH.sub.2CH.sub.2O, Cl), (M-11451, CH.sub.3, F, Cl,
PhCH.sub.2CH.sub.2O, F), (M-11452, CH.sub.3, F, Cl,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-11453, CH.sub.3, F, Cl,
PhCH.sub.2CH.sub.2O, Br), (M-11454, CH.sub.3, F, Cl,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-11455, CH.sub.3, F, Cl,
CF.sub.3O, H), (M-11456, CH.sub.3, F, Cl, CF.sub.3O, Cl), (M-11457,
CH.sub.3, F, Cl, CF.sub.3O, F), (M-11458, CH.sub.3, F, Cl,
CF.sub.3O, CF.sub.3), (M-11459, CH.sub.3, F, Cl, CF.sub.3O, Br),
(M-11460, CH.sub.3, F, Cl, CF.sub.3O, CH.sub.3), (M-11461,
CH.sub.3, F, Cl, Ph, H), (M-11462, CH.sub.3, F, Cl, Ph, Cl),
(M-11463, CH.sub.3, F, Cl, Ph, F), (M-11464, CH.sub.3, F, Cl, Ph,
CF.sub.3), (M-11465, CH.sub.3, F, Cl, Ph, Br), (M-11466, CH.sub.3,
F, Cl, Ph, CH.sub.3), (M-11467, CH.sub.3, F, Cl, 4-F-Ph, H),
(M-11468, CH.sub.3, F, Cl, 4-F-Ph, Cl), (M-11469, CH.sub.3, F, Cl,
4-F-Ph, F), (M-11470, CH.sub.3, F, Cl, 4-F-Ph, CF.sub.3), (M-11471,
CH.sub.3, F, Cl, 4-F-Ph, Br), (M-11472, CH.sub.3, F, Cl, 4-F-Ph,
CH.sub.3), (M-11473, CH.sub.3, F, Cl, 4-CF.sub.3-Ph, H), (M-11474,
CH.sub.3, F, Cl, 4-CF.sub.3-Ph, Cl), (M-11475, CH.sub.3, F, Cl,
4-CF.sub.3-Ph, F), (M-11476, CH.sub.3, F, Cl, 4-CF.sub.3-Ph,
CF.sub.3), (M-11477, CH.sub.3, F, Cl, 4-CF.sub.3-Ph, Br), (M-11478,
CH.sub.3, F, Cl, 4-CF.sub.3-Ph, CH.sub.3), (M-11479, CH.sub.3, F,
Cl, 4-(Me).sub.2N-Ph, H), (M-11480, CH.sub.3, F, Cl, 4-(Me).sub.2N,
Ph, Cl), (M-11481, CH.sub.3, F, Cl, 4-(Me).sub.2N-Ph, F), (M-11482,
CH.sub.3, F, Cl, 4-(Me).sub.2N-Ph, CF.sub.3), (M-11483, CH.sub.3,
F, Cl, 4-(Me).sub.2N-Ph, Br), (M-11484, CH.sub.3, F, Cl,
4-(Me).sub.2N-Ph, CH.sub.3), (M-11485, CH.sub.3, F, Cl, 4-OH-Ph,
H), (M-11486, CH.sub.3, F, Cl, 4-OH-Ph, Cl), (M-11487, CH.sub.3, F,
Cl, 4-OH-Ph, F), (M-11488, CH.sub.3, F, Cl, 4-OH-Ph, CF.sub.3),
(M-11489, CH.sub.3, F, Cl, 4-OH-Ph, Br), (M-11490, CH.sub.3, F, Cl,
4-OH-Ph, CH.sub.3), (M-11491, CH.sub.3, F, Cl, 3,4-di-F-Ph, H),
(M-11492, CH.sub.3, F, Cl, 3,4-di-F-Ph, Cl), (M-11493, CH.sub.3, F,
Cl, 3,4-di-F-Ph, F), (M-11494, CH.sub.3, F, Cl, 3,4-di-F-Ph,
CF.sub.3), (M-11495, CH.sub.3, F, Cl, 3,4-di-F-Ph, Br), (M-11496,
CH.sub.3, F, Cl, 3,4-di-F-Ph, CH.sub.3), (M-11497, CH.sub.3, F, Cl,
4-COOH-Ph, H), (M-11498, CH.sub.3, F, Cl, 4-COOH-Ph, Cl), (M-11499,
CH.sub.3, F, Cl, 4-COOH-Ph, F), (M-11500, CH.sub.3, F, Cl,
4-COOH-Ph, CF.sub.3), (M-11501, CH.sub.3, F, Cl, 4-COOH-Ph, Br),
(M-11502, CH.sub.3, F, Cl, 4-COOH-Ph, CH.sub.3), (M-11503,
CH.sub.3, F, Cl, Bn, H), (M-11504, CH.sub.3, F, Cl, Bn, Cl),
(M-11505, CH.sub.3, F, Cl, Bn, F), (M-11506, CH.sub.3, F, Cl, Bn,
CF.sub.3), (M-11507, CH.sub.3, F, Cl, Bn, Br), (M-11508, CH.sub.3,
F, Cl, Bn, CH.sub.3), (M-11509, CH.sub.3, F, Cl, 4-F-Bn, H),
(M-11510, CH.sub.3, F, Cl, 4-F-Bn, Cl), (M-11511, CH.sub.3, F, Cl,
4-F-Bn, F), (M-11512, CH.sub.3, F, Cl, 4-F-Bn, CF.sub.3), (M-11513,
CH.sub.3, F, Cl, 4-F-Bo, Br), (M-11514, CH.sub.3, F, Cl, 4-F-Bn,
CH.sub.3), (M-11510, CH.sub.3, F, Cl, 2-Py, H), (M-11516, CH.sub.3,
F, Cl, 2-Py, Cl), (M-11517, CH.sub.3, F, Cl, 2-Py, F), (M-11518,
CH.sub.3, F, Cl, 2-Py, CF.sub.3), (M-11519, CH.sub.3, F, Cl, 2-Py,
Br), (M-11520, CH.sub.3, F, Cl, 2-Py, CH.sub.3), (M-11521,
CH.sub.3, F, Cl, 3-Py, H), (M-11522, CH.sub.3, F, Cl, 3-Py, Cl),
(M-11523, CH.sub.3, F, Cl, 3-Py, P), (M-11524, CH.sub.3, F, Cl,
3-Py, CF.sub.3), (M-11525, CH.sub.3, F, Cl, 3-Py, Br), (M-11526,
CH.sub.3, F, Cl, 3-Py, CH.sub.3), (M-11527, CH.sub.3, F, Cl, 4-Py,
H), (M-11528, CH.sub.3, F, Cl, 4-Py, Cl), (M-11529, CH.sub.3, F,
Cl, 4-Py, F), (M-11530, CH.sub.3, F, Cl, 4-Py, CF.sub.3), (M-11531,
CH.sub.3, F, Cl, 4-Py, Br), (M-11532, CH.sub.3, F, Cl, 4-Py,
CH.sub.3), (M-11533, CH.sub.3, F, Cl, 2-Th, H), (M-11534, CH.sub.3,
F, Cl, 2-Th, Cl), (M-11535, CH.sub.3, F, Cl, 2-Th, F), (M-11536,
CH.sub.3, F, Cl, 2-Th, CF.sub.3), (M-11537, CH.sub.3, F, Cl, 2-Th,
Br), (M-11538, CH.sub.3, F, Cl, 2-Th, CH.sub.3), (M-11539,
CH.sub.3, F, Cl, 3-Th, H), (M-11540, CH.sub.3, F, Cl, 3-Th, Cl),
(M-11541, CH.sub.3, F, Cl, 3-Th, F), (M-11542, CH.sub.3, F, Cl,
3-Th, CF.sub.3), (M-11543, CH.sub.3, F, Cl, 3-Th, Br), (M-11544,
CH.sub.3, F, Cl, 3-Th, CH.sub.3), (M-11545, CH.sub.3, F, Cl,
pyrrazol-2-yl, H), (M-11546, CH.sub.3, F, Cl, pyrrazol-2-yl, Cl),
(M-11547, CH.sub.3, F, Cl, pyrrazol-2-yl, F), (M-11548, CH.sub.3,
F, Cl, pyrrazol-2-yl, CF.sub.3), (M-11549, CH.sub.3, F, Cl,
pyrrazol-2-yl, Br), (M-11550, CH.sub.3, F, Cl, pyrrazol-2-yl,
CH.sub.3), (M-11551, CH.sub.3, F, Cl, pyrrazol-3-yl, H), (M-11552,
CH.sub.3, F, Cl, pyrrazol-3-yl, Cl), (M-11553, CH.sub.3, F, Cl,
pyrrazol-3-yl, F), (M-11554, CH.sub.3, F, Cl, pyrrazol-3-yl,
CF.sub.3), (M-11555, CH.sub.3, F, Cl, pyrrazol-3-yl, Br), (M-11556,
CH.sub.3, F, Cl, pyrazol-3-yl, CH.sub.3), (M-11557, CH.sub.3, F,
Cl, pyrimidin-2-yl, H), (M-11558, CH.sub.3, F, Cl, pyrimidin-2-yl,
Cl), (M-11559, CH.sub.3, F, Cl, pyrimidin-2-yl, F), (M-11560,
CH.sub.3, F, Cl, pyrimidin-2-yl, CF.sub.3), (M-11561, CH.sub.3, F,
Cl, pyrimidin-2-yl, Br), (M-11562, CH.sub.3, F, Cl, pyrimidin-2-yl,
CH.sub.3), (M-11563, CH.sub.3, F, Cl, pyrimidin-4-yl, H), (M-11564,
CH.sub.3, F, Cl, pyrimidin-4-yl, Cl), (M-11565, CH.sub.3, F, Cl,
pyrimidin-4-yl, F), (M-11566, CH.sub.3, F, Cl, pyrimidin-4-yl,
CF.sub.3), (M-11567, CH.sub.3, F, Cl, pyrimidin-4-yl, Br),
(M-11568, CH.sub.3, F, Cl, pyrimidin-4-yl, CH.sub.3), (M-11569,
CH.sub.3, F, Cl, pyrimidin-5-yl, H), (M-11570, CH.sub.3, F, Cl,
pyrimidin-5-yl, Cl), (M-11571, CH.sub.3, F, Cl, pyrimidin-5-yl, F),
(M-11572, CH.sub.3, F, Cl, pyrimidin-5-yl, CF.sub.3), (M-11573,
CH.sub.3, F, Cl, pyrimidin-5-yl, Br), (M-11574, CH.sub.3, F, Cl,
pyrimidin-5-yl, CH.sub.3), (M-11575, CH.sub.3, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-11576, CH.sub.3, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-11577, CH.sub.3, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-11578, CH.sub.3, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-11579, CH.sub.3, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-11580, CH.sub.3, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-11581, CH.sub.3, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-11582, CH.sub.3, F,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-11583, CH.sub.3,
F, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-11584,
CH.sub.3, F, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-11585, CH.sub.3, F, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-11586, CH.sub.3, F, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-11587,
CH.sub.3, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-11588, CH.sub.3, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-11589,
CH.sub.3, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-11590, CH.sub.3, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-11591,
CH.sub.3, F, Cl, (Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
Br), (M-11592, CH.sub.3, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-11593,
CH.sub.3, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2C.sub.2, H), (M-11594,
CH.sub.3, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-11595, CH.sub.3, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-11596, CH.sub.3, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-11597, CH.sub.3, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-11598, CH.sub.3, F, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-11599, CH.sub.3, F, Cl, MeOCH.sub.2, H), (M-11600, CH.sub.3, F,
Cl, MeOCH.sub.2, Cl), (M-11601, CH.sub.3, F, Cl, MeOCH.sub.2, F),
(M-11602, CH.sub.3, F, Cl, MeOCH.sub.2, CF.sub.3), (M-11603,
CH.sub.3, F, Cl, MeOCH.sub.2, Br), (M-11604, CH.sub.3, F, Cl,
MeOCH.sub.2, CH.sub.3), (M-11605, CH.sub.3, F, Cl, EtOCH.sub.2, H),
(M-11606, CH.sub.3, F, Cl, EtOCH.sub.2, Cl), (M-11607, CH.sub.3, F,
Cl, EtOCH.sub.2, F), (M-11608, CH.sub.3, F, Cl, EtOCH.sub.2,
CF.sub.3), (M-11609, CH.sub.3, F, Cl, EtOCH.sub.2, Br), (M-101610,
CH.sub.3, F, Cl, EtOCH.sub.2, CH.sub.3), (M-11611, CH.sub.3, F, Cl,
EtOCH.sub.2CH.sub.2, H), (M-11612, CH.sub.3, F, Cl,
EtOCH.sub.2CH.sub.2, Cl), (M-11613, CH.sub.3, F, Cl,
EtOCH.sub.2CH.sub.2, F), (M-11614, CH.sub.3, F, Cl,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-11615, CH.sub.3, F, Cl,
EtOCH.sub.2CH.sub.2, Br), (M-11616, CH.sub.3, F, Cl,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-11617, CH.sub.3, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-11618, CH.sub.3, F,
Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-11619, CH.sub.3,
F, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-11620,
CH.sub.3, F, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3),
(M-11621, CH.sub.3, F, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
Br), (M-11622, CH.sub.3, F, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-11623,
CH.sub.3, F, Cl, MeOCH.sub.2CH.sub.2, H), (M-11624, CH.sub.3, F,
Cl, MeOCH.sub.2CH.sub.2, Cl), (M-11625, CH.sub.3, F, Cl,
MeOCH.sub.2CH.sub.2, F), (M-11626, CH.sub.3, F, Cl,
MeOCH.sub.2CH.sub.2, CF.sub.3), (M-11627, CH.sub.3, F, Cl,
MeOCH.sub.2CH.sub.2, Br), (M-11628, CH.sub.3, F, Cl,
MeOCH.sub.2CH.sub.2, CH.sub.3), (M-11629, CH.sub.3, F, Cl,
HOCH.sub.2, H), (M-11630, CH.sub.3, F, Cl, HOCH.sub.2, Cl),
(M-11631, CH.sub.3, F, Cl, HOCH.sub.2, F), (M-11632, CH.sub.3, F,
Cl, HOCH.sub.2, CF.sub.3), (M-11633, CH.sub.3, F, Cl, HOCH.sub.2,
Br), (M-11634, CH.sub.3, F, Cl, HOCH.sub.2, CH.sub.3), (M-11635,
CH.sub.3, F, Cl, HOCH.sub.2CH.sub.2, H), (M-11636, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2, Cl), (M-11637, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2, F), (M-11638, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-11639, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2, Br), (M-11640, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-11641, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-11642, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-11643, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-11644, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-11645, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-11646, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-11647, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-11648, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-11649, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-11650, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-11651, CH.sub.3,
F, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-11652, CH.sub.3,
F, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-11653,
CH.sub.3, F, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H),
(M-11654, CH
.sub.3, F, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-11655, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-11656, CH.sub.3,
F, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-11657, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-11658,
CH.sub.3, F, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-11659, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-11860, CH.sub.3, F, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-11661, CH.sub.3, F,
Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-11662, CH.sub.3, F,
Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-11663,
CH.sub.3, F, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-11664, CH.sub.3, F, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-11665, CH.sub.3, F, Cl, (Me).sub.2N, H), (M-11666,
CH.sub.3, F, Cl, (Me).sub.2N, Cl), (M-11667, CH.sub.3, F, Cl,
(Me).sub.2N, F), (M-11668, CH.sub.3, F, Cl, (Me).sub.2N, CF.sub.3),
(M-11669, CH.sub.3, F, Cl, (Me).sub.2N, Br), (M-11670, CH.sub.3, F,
Cl, (Me).sub.2N, CH.sub.3), (M-11671, CH.sub.3, F, Cl,
piperidin-4-yl-methyl, H), (M-11672, CH.sub.3, F, Cl,
piperidin-4-yl-methyl, Cl), (M-11673, CH.sub.3, F, Cl,
piperidin-4-yl-methyl, F), (M-11674, CH.sub.3, F, Cl,
piperidin-4-yl-methyl, CF.sub.3), (M-11675, CH.sub.3, F, Cl,
piperidin-4-yl-methyl, Br), (M-11676, CH.sub.3, F, Cl,
piperidin-4-yl-methyl, CH.sub.3), (M-11677, CH.sub.3, F, Cl,
cyclohexylmethyl, H), (M-11678, CH.sub.3, F, Cl, cyclohexylmethyl,
Cl), (M-11679, CH.sub.3, F, Cl, cyclohexylmethyl, F), (M-11680,
CH.sub.3, F, Cl, cyclohexylmethyl, CF.sub.3), (M-11681, CH.sub.3,
F, Cl, cyclohexylmethyl, Br), (M-11682, CH.sub.3, F, Cl,
cyclohexylmethyl, CH.sub.3), (M-11683, CH.sub.3, CH.sub.3, H, H,
H), (M-11684, CH.sub.3, CH.sub.3, H, H, Cl), (M-11685, CH.sub.3,
CH.sub.3, H, H, F), (M-11686, CH.sub.3, CH.sub.3, H, H, CF.sub.3),
(M-11687, CH.sub.3, CH.sub.3, H, H, Br), (M-11688, CH.sub.3,
CH.sub.3, H, H, CH.sub.3), (M-11689, CH.sub.3, CH.sub.3, H, F, H),
(M-11690, CH.sub.3, CH.sub.3, H, F, Cl), (M-11691, CH.sub.3,
CH.sub.3, H, F, F), (M-11692, CH.sub.3, CH.sub.3, H, F, CF.sub.3),
(M-11693, CH.sub.3, CH.sub.3, H, F, Br), (M-11694, CH.sub.3,
CH.sub.3, H, F, CH.sub.3), (M-11695, CH.sub.3, CH.sub.3, H, Cl, H),
(M-11696, CH.sub.3, CH.sub.3, H, Cl, Cl), (M-11697, CH.sub.3,
CH.sub.3, H, Cl, F), (M-11698, CH.sub.3, CH.sub.3, H, Cl,
CF.sub.3), (M-11699, CH.sub.3, CH.sub.3, H, Cl, Br), (M-11700,
CH.sub.3, CH.sub.3, H, Cl, CH.sub.3), (M-11701, CH.sub.3, CH.sub.3,
H, CH.sub.3, H), (M-11702, CH.sub.3, CH.sub.3, H, CH.sub.3, Cl),
(M-11703, CH.sub.3, CH.sub.3, H, CH.sub.3, F), (M-11704, CH.sub.3,
CH.sub.3, H, CH.sub.3, CF.sub.3), (M-11705, CH.sub.3, CH.sub.3, H,
CH.sub.3, Br), (M-11706, CH.sub.3, CH.sub.3, H, CH.sub.3,
CH.sub.3), (M-11707, CH.sub.3, CH.sub.3, H, Et, H), (M-11708,
CH.sub.3, CH.sub.3, H, Et, Cl), (M-11709, CH.sub.2, CH.sub.3, H,
Et, F), (M-11710, CH.sub.3, CH.sub.3, H, Et, CF.sub.3), (M-11711,
CH.sub.3, CH.sub.3, H, Et, Br), (M-11712, CH.sub.3, CH.sub.3, H,
Et, CH.sub.3), (M-11713, CH.sub.3, CH.sub.3, H, n-Pr, H), (M-11714,
CH.sub.3, CH.sub.3, H, n-Pr, CL), (M-11715, CH.sub.3, CH.sub.3, H,
n-Pr, F), (M-11716, CH.sub.3, CH.sub.3, H, n-Pr, CF.sub.3),
(M-11717, CH.sub.3, CH.sub.3, H, n-Pr, Br), (M-11718, CH.sub.3,
CH.sub.3, H, n-Pr, CH.sub.3), (M-11719, CH.sub.3, CH.sub.3, H,
c-Pr, H), (M-11720, CH.sub.3, CH.sub.3, H, c-Pr, Cl), (M-11721,
CH.sub.3, CH.sub.3, H, c-Pr, F), (M-11722, CH.sub.3, CH.sub.3, H,
c-Pr, CF.sub.3), (M-11723, CH.sub.3, CH.sub.3, H, c-Pr, Br),
(M-11724, CH.sub.3, CH.sub.3, H, c-Pr, CH.sub.3), (M-11725,
CH.sub.3, CH.sub.3, H, i-Pr, H), (M-11726, CH.sub.3, CH.sub.3, H,
i-Pr, Cl), (M-11727, CH.sub.3, CH.sub.3, H, i-Pr, F), (M-11728,
CH.sub.3, CH.sub.3, H, i-Pr, CF.sub.3), (M-11729, CH.sub.3,
CH.sub.3, H, i-Pr, Br), (M-11730, CH.sub.3, CH.sub.3, H, i-Pr,
CH.sub.3), (M-11731, CH.sub.3, CH.sub.3, H, n-Bu, H), (M-11732,
CH.sub.3, CH.sub.3, H, n-Bu, Cl), (M-11733, CH.sub.3, CH.sub.3, H,
n-Bu, F), (M-11734, CH.sub.3, CH.sub.3, H, n-Bu, CF.sub.3),
(M-11735, CH.sub.3, CH.sub.3, H, n-Bu, Br), (M-11736, CH.sub.3,
CH.sub.3, H, n-Bu, CH.sub.3), (M-11737, CH.sub.3, CH.sub.3, H,
i-Bu, H), (M-11738, CH.sub.3, CH.sub.3, H, i-Bu, Cl), (M-11739,
CH.sub.3, CH.sub.3, H, i-Bu, F), (M-11740, CH.sub.3, CH.sub.3, H,
i-Bu, CF.sub.3), (M-11741, CH.sub.3, CH.sub.3, H, i-Bu, Br),
(M-11742, CH.sub.3, CH.sub.3, H, i-Bu, CH.sub.3), (M-11743,
CH.sub.3, CH.sub.3, H, sec-Bu, H), (M-11744, CH.sub.3, CH.sub.3, H,
sec-Bu, Cl), (M-11745, CH.sub.3, CH.sub.3, H, sec-Bu, F), (M-11746,
CH.sub.3, CH.sub.3, H, sec-Bu, CF.sub.3), (M-11747, CH.sub.3,
CH.sub.3, H, sec-Bu, Br), (M-11748, CH.sub.3, CH.sub.3, H, sec-Bu,
CH.sub.3), (M-11749, CH.sub.3, CH.sub.3, H, n-Pen, H), (M-11750,
CH.sub.3, CH.sub.3, H, n-Pen, Cl), (M-11751, CH.sub.3, CH.sub.3, H,
n-Pen, F), (M-11752, CH.sub.3, CH.sub.3, H, n-Pen, CF.sub.3),
(M-11753, CH.sub.3, CH.sub.3, H, n-Pen, Br), (M-11754, CH.sub.3,
CH.sub.3, H, n-Pen, CH.sub.3), (M-11755, CH.sub.3, CH.sub.3, H,
c-Pen, H), (M-11756, CH.sub.3, CH.sub.3, H, c-Pen, Cl), (M-11757,
CH.sub.3, CH.sub.3, H, c-Pen, F), (M-11758, CH.sub.3, CH.sub.3, H,
c-Pen, CF.sub.3), (M-11759, CH.sub.3, CH.sub.3, H, c-Pen, Br),
(M-11760, CH.sub.3, CH.sub.3, H, c-Pen, CH.sub.3), (M-11761,
CH.sub.3, CH.sub.3, H, n-Hex, H), (M-11762, CH.sub.3, CH.sub.3, H,
n-Hex, Cl), (M-11763, CH.sub.3, CH.sub.3, H, n-Hex, F), (M-11764,
CH.sub.3, CH.sub.3, H, n-Hex, CF.sub.3), (M-11765, CH.sub.3,
CH.sub.3, H, n-Hex, Br), (M-11766, CH.sub.3, CH.sub.3, H, n-Hex,
CH.sub.3), (M-11767, CH.sub.3, CH.sub.3, H, c-Hex, H), (M-11768,
CH.sub.3, CH.sub.3, H, c-Hex, Cl), (M-11769, CH.sub.3, CH.sub.3, H,
c-Hex, F), (M-11770, CH.sub.3, CH.sub.3, H, c-Hex, CF.sub.3),
(M-11771, CH.sub.3, CH.sub.3, H, c-Hex, Br), (M-11772, CH.sub.3,
CH.sub.3, H, c-Hex, CH.sub.3), (M-11773, CH.sub.3, CH.sub.3, H, OH,
H), (M-11774, CH.sub.3, CH.sub.3, H, OH, Cl), (M-11775, CH.sub.3,
CH.sub.3, H, OH, F), (M-11776, CH.sub.3, CH.sub.3, H, OH,
CF.sub.3), (M-11777, CH.sub.3, CH.sub.3, H, OH, Br), (M-11778,
CH.sub.3, CH.sub.3, H, OH, CH.sub.3), (M-11779, CH.sub.3, CH.sub.3,
H, EtO, H), (M-11780, CH.sub.3, CH.sub.3, H, EtO, Cl), (M-11781,
CH.sub.3, CH.sub.3, H, EtO, F), (M-11782, CH.sub.3, CH.sub.3, H,
EtO, CF.sub.3), (M-11783, CH.sub.3, CH.sub.3, H, EtO, Br),
(M-11784, CH.sub.3, CH.sub.3, H, EtO, CH.sub.3), (M-11785,
CH.sub.3, CH.sub.3, H, n-PrO, H), (M-11786, CH.sub.3, CH.sub.3, H,
n-PrO, Cl), (M-11787, CH.sub.3, CH.sub.3, H, n-PrO, F), (M-11788,
CH.sub.3, CH.sub.3, H, n-PrO, CF.sub.3), (M-11789, CH.sub.3,
CH.sub.3, H, n-PrO, Br), (M-11790, CH.sub.3, CH.sub.3, H, n-PrO,
CH.sub.3), (M-11791, CH.sub.3, CH.sub.3, H, PhO, H), (M-11792,
CH.sub.3, CH.sub.3, H, PhO, Cl), (M-11793, CH.sub.3, CH.sub.3, H,
PhO, F), (M-11794, CH.sub.3, CH.sub.3, H, PhO, CF.sub.3), (M-11795,
CH.sub.3, CH.sub.3, H, PhO, Br), (M-11796, CH.sub.3, CH.sub.3, H,
PhO, CH.sub.3), (M-11797, CH.sub.3, CH.sub.3, H, BnO, H), (M-11798,
CH.sub.3, CH.sub.3, H, BnO, Cl), (M-11799, CH.sub.3, CH.sub.3, H,
BnO, F), (M-11800, CH.sub.3, CH.sub.3, H, BnO, CF.sub.3), (M-11801,
CH.sub.3, CH.sub.3, H, BnO, Br), (M-11802, CH.sub.3, CH.sub.3, H,
BnO, CH.sub.3), (M-11803, CH.sub.3, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, H), (M-11804, CH.sub.3, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, Cl), (M-11805, CH.sub.3, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, F), (M-11806, CH.sub.3, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-11807, CH.sub.3, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, Br), (M-11808, CH.sub.3, CH.sub.3, H,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-11809, CH.sub.3, CH.sub.3, H,
CF.sub.3O, H), (M-11810, CH.sub.3, CH.sub.3, H, CF.sub.3O, Cl),
(M-11811, CH.sub.3, CH.sub.3, H, CF.sub.3O, E), (M-11812, CH.sub.3,
CH.sub.3, H, CF.sub.3O, CF.sub.3), (M-11813, CH.sub.3, CH.sub.3, H,
CF.sub.3O, Br), (M-11814, CH.sub.3, CH.sub.3, H, CF.sub.3O,
CH.sub.3), (M-11815, CH.sub.3, CH.sub.3, H, Ph, H), (M-11816,
CH.sub.3, CH.sub.3, H, Ph, Cl), (M-11817, CH.sub.3, CH.sub.3, H,
Ph, F), (M-11818, CH.sub.3, CH.sub.3, H, Ph, CF.sub.3), (M-11819,
CH.sub.3, CH.sub.3, H, Ph, Br), (M-11820, CH.sub.3, CH.sub.3, H,
Ph, CH.sub.3), (M-11821, CH.sub.3, CH.sub.3, H, 4-F-Ph, H),
(M-11822, CH.sub.3, CH.sub.3, H, 4-F-Ph, Cl), (M-11823, CH.sub.3,
CH.sub.3, H, 4-F-Ph, F), (M-11824, CH.sub.3, CH.sub.3, H, 4-F-Ph,
CF.sub.3), (M-11825, CH.sub.3, CH.sub.3, H, 4-F-Ph, Br), (M-11826,
CH.sub.3, CH.sub.3, H, 4-F-Ph, CH.sub.3), (M-11827, CH.sub.3,
CH.sub.3, H, 4-CF.sub.3-Ph, H), (M-11828, CH.sub.3, CH.sub.3, H,
4-CF.sub.3-Ph, Cl), (M-11829, CH.sub.3, CH.sub.3, H, 4-CF.sub.3-Ph,
F), (M-11830, CH.sub.3, CH.sub.3, H, 4-CF.sub.3-Ph, CF.sub.3),
(M-11831, CH.sub.3, CH.sub.3, H, 4-CF.sub.3-Ph, Br), (M-11832,
CH.sub.3, CH.sub.3, H, 4-CF.sub.3-Ph, CH.sub.3), (M-11833,
CH.sub.3, CH.sub.3, H, 4-(Me).sub.2N-Ph, H), (M-11834, CH.sub.3,
CH.sub.3, H, 4-(Me).sub.2N-Ph, Cl), (M-11835, CH.sub.3, CH.sub.3,
H, 4-(Me).sub.2N-Ph, F), (M-11836, CH.sub.3, CH.sub.3, H,
4-(Me).sub.2N-Ph, CF.sub.3), (M-11837, CH.sub.3, CH.sub.3, H,
4-(Me).sub.2N-Ph, Br), (M-11838, CH.sub.3, CH.sub.3, H,
4-(Me).sub.2N-Ph, CH.sub.3), (M-11839, CH.sub.3, CH.sub.3, H,
4-OH-Ph, H), (M-11840, CH.sub.3, CH.sub.3, H, 4-OH-Ph, Cl),
(M-11841, CH.sub.3, CH.sub.3, H, 4-OH-Ph, F), (M-11842, CH.sub.3,
CH.sub.3, H, 4-OH-Ph, CF.sub.3), (M-11843, CH.sub.3, CH.sub.3, H,
4-OH-Ph, Br), (M-11844, CH.sub.3, CH.sub.3, H, 4-OH-Ph, CH.sub.3),
(M-11845, CH.sub.3, CH.sub.3, H, 3,4-di-F-Ph, H), (M-11846,
CH.sub.3, CH.sub.3, H, 3,4-di-F-Ph, Cl), (M-11847, CH.sub.3,
CH.sub.3, H, 3,4-di-F-Ph, F), (M-11848, CH.sub.3, CH.sub.3, H,
3,4-di-F-Ph, CF.sub.3), (M-11849, CH.sub.3, CH.sub.3, H,
3,4-di-F-Ph, Br), (M-11850, CH.sub.3, CH.sub.3, H, 3,4-di-F-Ph,
CH.sub.3), (M-11851, CH.sub.3, CH.sub.3, H, 4-COOH-Ph, H),
(M-11852, CH.sub.3, CH.sub.3, H, 4-COOH-Ph, Cl), (M-11853,
CH.sub.3, CH.sub.3, H, 4-COOH-Ph, F), (M-11854, CH.sub.3, CH.sub.3,
H, 4-COOH-Ph, CF.sub.3), (M-11855, CH.sub.3, CH.sub.3, H,
4-COOH-Ph, Br), (M-11856, CH.sub.3, CH.sub.3, H, 4-COOH-Ph,
CH.sub.3), (M-11857, CH.sub.3, CH.sub.3, H, Bn, H), (M-11858,
CH.sub.3, CH.sub.3, H, Bn, Cl), (M-11859, CH.sub.3, CH.sub.3, H,
Bn, F), (M-11860, CH.sub.3, CH.sub.3, H, Bn, CF.sub.3), (M-11861,
CH.sub.3, CH.sub.3, H, Bn, Br), (M-11862, CH.sub.3, CH.sub.3, H,
Bn, CH.sub.3), (M-11863, CH.sub.3, CH.sub.3, H, 4-F-Bn, H),
(M-11864, CH.sub.3, CH.sub.3, H, 4-F-Bn, Cl), (M-11865, CH.sub.3,
CH.sub.3, H, 4-F-Bn, F), (M-11866, CH.sub.3, CH.sub.3, H, 4-F-Bn,
CF.sub.3), (M-11867, CH.sub.3, CH.sub.3, H, 4-F-Bn, Br), (M-11868,
CH.sub.3, CH.sub.3, H, 4-F-Bn, CH.sub.3), (M-11869, CH.sub.3,
CH.sub.3, H, 2-Py, H), (M-11870, CH.sub.3, CH.sub.3, H, 2-Py, Cl),
(M-11871, CH.sub.3, CH.sub.3, H, 2-Py, F), (M-11872, CH.sub.3,
CH.sub.3, H, 2-Py, CF.sub.3), (M-11873, CH.sub.3, CH.sub.3, H,
2-Py, Br), (M-11874, CH.sub.3, CH.sub.3, H, 2-Py, CH.sub.3),
(M-11875, CH.sub.3, CH.sub.3, H, 3-Py, H), (M-11876, CH.sub.3,
CH.sub.3, H, 3-Py, Cl), (M-11877, CH.sub.3, CH.sub.3, H, 3-Py, F),
(M-11878, CH.sub.3, CH.sub.3, H, 3-Py, CF.sub.3), (M-11879,
CH.sub.3, CH.sub.3, H, 3-Py, Br), (M-11880, CH.sub.3, CH.sub.3, H,
3-Py, CH.sub.3), (M-11881, CH.sub.3, CH.sub.3, H, 4-Py, H),
(M-11882, CH.sub.3, CH.sub.3, H, 4-Py, Cl), (M-11883, CH.sub.3,
CH.sub.3, H, 4-Py, F), (M-11884, CH.sub.3, CH.sub.3, H, 4-Py,
CF.sub.3), (M-11885, CH.sub.3, CH.sub.3, H, 4-Py, Br), (M-11886,
CH.sub.3, CH.sub.3, H, 4-Py, CH.sub.3), (M-11887, CH.sub.3,
CH.sub.3, H, 2-Th, H), (M-11888, CH.sub.3, CH.sub.3, H, 2-Th, Cl),
(M-11889, CH.sub.3, CH.sub.3, H, 2-Th, F), (M-11890, CH.sub.3,
CH.sub.3, H, 2-Th, CF.sub.3), (M-11891, CH.sub.3, CH.sub.3, H,
2-Th, Br), (M-11892, CH.sub.3, CH.sub.3, H, 2-Th, CH.sub.3),
(M-11893, CH.sub.3, CH.sub.3, H, 3-Th, H), (M-11894, CH.sub.3,
CH.sub.3, H, 3-Th, Cl), (M-11895, CH.sub.3, CH.sub.3, H, 3-Th, F),
(M-11896, CH.sub.3, CH.sub.3, H, 3-Th, CF.sub.3), (M-11897,
CH.sub.3, CH.sub.3, H, 3-Th, Br), (M-11898, CH.sub.3, CH.sub.3, H,
3-Th, CH.sub.3), (M-11899, CH.sub.3, CH.sub.3, H, pyrrazol-2-yl,
H), (M-11900, CH.sub.2, CH.sub.3, H, pyrrazol-2-yl, Cl), (M-11901,
CH.sub.3, CH.sub.3, H, pyrrazol-2-yl, F), (M-11902, CH.sub.3,
CH.sub.3, H, pyrrazol-2-yl, CF.sub.3), (M-11903, CH.sub.3,
CH.sub.3, H, pyrrazol-2-yl, Br), (M-11904, CH.sub.3, CH.sub.3, H,
pyrrazol-2-yl, CH.sub.3), (M-11905, CH.sub.3, CH.sub.3, H,
pyrrazol-3-yl, H), (M-11906, CH.sub.3, CH.sub.3, H, pyrrazol-3-yl,
Cl), (M-11907, CH.sub.3, CH.sub.3, H, pyrrazol-3-yl, F), (M-11908,
CH.sub.3, CH.sub.3, H, pyrrazol-3-yl, CF.sub.3), (M-11909,
CH.sub.3, CH.sub.3, H, pyrrazol-3-yl, Br), (M-11910, CH.sub.3,
CH.sub.3, H, pyrrazol-3-yl, CH.sub.3), (M-11911, CH.sub.3,
CH.sub.3, H, pyrimidin-2-yl, H), (M-11912, CH.sub.3, CH.sub.3, H,
pyrimidin-2-yl, Cl), (M-11913, CH.sub.3, CH.sub.3, H,
pyrimidin-2-yl, F), (M-11914, CH.sub.3, CH.sub.3, H,
pyrimidin-2-yl, CF.sub.3), (M-11915, CH.sub.3, CH.sub.3, H,
pyrimidin-2-yl, Br), (M-11916, CH.sub.3, CH.sub.3, H,
pyrimidin-2-yl, CH.sub.3), (M-11917, CH.sub.3, CH.sub.3, H,
pyrimidin-4-yl, H), (M-11918, CH.sub.3, CH.sub.3, H,
pyrimidin-4-yl, Cl), (M-11919, CH.sub.3, CH.sub.3, H,
pyrimidin-4-yl, F), (M-11920, CH.sub.3, CH.sub.3, H,
pyrimidin-4-yl, CF.sub.3), (M-11921, CH.sub.3, CH.sub.3, H,
pyrimidin-4-yl, Br), (M-11922, CH.sub.3, CH.sub.3, H,
pyrimidin-4-yl, CH.sub.3), (M-11923, CH.sub.3, CH.sub.3, H,
pyrimidin-5-yl, H), (M-11924, CH.sub.3, CH.sub.3, H,
pyrimidin-5-yl, Cl), (M-11925, CH.sub.3, CH.sub.3, H,
pyrimidin-5-yl, F), (M-11926, CH.sub.3, CH.sub.3, H,
pyrimidin-5-yl, CF.sub.3), (M-11927, CH.sub.3, CH.sub.3, H,
pyrimidin-5-yl, Br), (M-11928, CH.sub.3, CH.sub.3, H,
pyrimidin-5-yl, CH.sub.3), (M-11929, CH.sub.3, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-11930, CH.sub.3, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-11931, CH.sub.3, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-11932, CH.sub.3, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-11933, CH.sub.3,
CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-11934, CH.sub.3,
CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-11935,
CH.sub.3, CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-11936, CH.sub.3, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-11937, CH.sub.3,
CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-11938,
CH.sub.3, CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-11939, CH.sub.3, CH.sub.3, H,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-11940, CH.sub.3,
CH.sub.3, H, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-11941, CH.sub.3, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-11942,
CH.sub.3, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-11943,
CH.sub.3, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-11944,
CH.sub.3, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-11945,
CH.sub.3, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-11946,
CH.sub.3, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-11947,
CH.sub.3, CH.sub.3, H, (Me)
.sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-11948,
CH.sub.3, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-11949, CH.sub.3, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-11950, CH.sub.3, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-11951, CH.sub.3, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-11952, CH.sub.3, CH.sub.3, H,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-11953, CH.sub.3, CH.sub.3, H, MeOCH.sub.2, H), (M-11954,
CH.sub.3, CH.sub.3, H, MeOCH.sub.2, Cl), (M-11955, CH.sub.3,
CH.sub.3, H, MeOCH.sub.2, F), (M-11956, CH.sub.3, CH.sub.3, H,
MeOCH.sub.2, CF.sub.3), (M-11957, CH.sub.3, CH.sub.3, H,
MeOCH.sub.2, Br), (M-11958, CH.sub.3, CH.sub.3, H, MeOCH.sub.2,
CH.sub.3), (M-11959, CH.sub.3, CH.sub.3, H, EtOCH.sub.2, H),
(M-11960, CH.sub.3, CH.sub.3, H, EtOCH.sub.2, Cl), (M-11961,
CH.sub.3, CH.sub.3, H, EtOCH.sub.2, F), (M-11962, CH.sub.3,
CH.sub.3, H, EtOCH.sub.2, CF.sub.3), (M-11963, CH.sub.3, CH.sub.3,
H, EtOCH.sub.2, Br), (M-11964, CH.sub.3, CH.sub.3, H, EtOCH.sub.2,
CH.sub.3), (M-11965, CH.sub.3, CH.sub.3, H, EtOCH.sub.2CH.sub.2,
H), (M-11966, CH.sub.3, CH.sub.3, H, EtOCH.sub.2CH.sub.2, Cl),
(M-11967, CH.sub.3, CH.sub.3, H, EtOCH.sub.2CH.sub.2, F), (M-11968,
CH.sub.3, CH.sub.3, H, EtOCH.sub.2CH.sub.2, CF.sub.3), (M-11969,
CH.sub.3, CH.sub.3, H, EtOCH.sub.2CH.sub.2, Br), (M-11970,
CH.sub.3, CH.sub.3, H, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-11971,
CH.sub.3, CH.sub.3, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H),
(M-11972, CH.sub.3, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-11973, CH.sub.3,
CH.sub.3, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-11974,
CH.sub.3, CH.sub.3, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CF.sub.3), (M-11975, CH.sub.3, CH.sub.3, H,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-110976, CH.sub.3,
CH.sub.3, H, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-11977, CH.sub.3, CH.sub.3, H, MeOCH.sub.2CH.sub.2, H), (M-11978,
CH.sub.3, CH.sub.3, H, MeOCH.sub.2CH.sub.2, Cl), (M-11979,
CH.sub.3, CH.sub.3, H, MeOCH.sub.2CH.sub.2, F), (M-11980, CH.sub.3,
CH.sub.3, H, MeOCH.sub.2CH.sub.2, CF.sub.3), (M-11981, CH.sub.3,
CH.sub.3, H, MeOCH.sub.2CH.sub.2, Br), (M-11982, CH.sub.3,
CH.sub.3, H, MeOCH.sub.2CH.sub.2, CH.sub.3), (M-11983, CH.sub.3,
CH.sub.3, H, HOCH.sub.2, H), (M-11984, CH.sub.3, CH.sub.3, H,
HOCH.sub.2, Cl), (M-11985, CH.sub.3, CH.sub.3, H, HOCH.sub.2, F),
(M-11986, CH.sub.3, CH.sub.3, H, HOCH.sub.2, CF.sub.3), (M-11987,
CH.sub.3, CH.sub.3, H, HOCH.sub.2, Br), (M-11988, CH.sub.3,
CH.sub.3, H, HOCH.sub.2, CH.sub.3), (M-11989, CH.sub.3, CH.sub.3,
H, HOCH.sub.2CH.sub.2, H), (M-11990, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2, Cl), (M-11991, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2, F), (M-11992, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-11993, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2, Br), (M-11994, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-11995, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-11996, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-11997, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-11998, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-11999, CH.sub.3,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-12000, CH.sub.3,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-12001,
CH.sub.3, CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-12002, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-12003, CH.sub.3,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-12004,
CH.sub.3, CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-12005, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-12006, CH.sub.3,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-12007, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-12008, CH.sub.3,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-12009, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-12010, CH.sub.3,
CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-12011, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-12012,
CH.sub.3, CH.sub.3, H, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CH.sub.3), (M-12013, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-12014, CH.sub.3,
CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-12015,
CH.sub.3, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-12016, CH.sub.3, CH.sub.3, H,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-12017, CH.sub.3,
CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-12018,
CH.sub.3, CH.sub.3, H, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-12019, CH.sub.3, CH.sub.3, H, (Me).sub.2N, H),
(M-12020, CH.sub.3, CH.sub.3, H, (Me).sub.2N, Cl), (M-12021,
CH.sub.3, CH.sub.3, H, (Me).sub.2N, F), (M-12022, CH.sub.3,
CH.sub.3, H, (Me).sub.2N, CF.sub.3), (M-12023, CH.sub.3, CH.sub.3,
H, (Me).sub.2N, Br), (M-12024, CH.sub.3, CH.sub.3, H, (Me).sub.2N,
CH.sub.3), (M-12025, CH.sub.3, CH.sub.3, H, piperidin-4-yl-methyl,
H), (M-12026, CH.sub.3, CH.sub.3, H, piperidin-4-yl-methyl, Cl),
(M-12027, CH.sub.3, CH.sub.3, H, piperidin-4-yl-methyl, F),
(M-12028, CH.sub.3, CH.sub.3, H, piperidin-4-yl-methyl, CF.sub.3),
(M-12029, CH.sub.3, CH.sub.3, H, piperidin-4-yl-methyl, Br),
(M-12030, CH.sub.3, CH.sub.3, H, piperidin-4-yl-methyl, CH.sub.3),
(M-12031, CH.sub.3, CH.sub.3, H, cyclohexylmethyl, H), (M-12032,
CH.sub.3, CH.sub.3, H, cyclohexylmethyl, Cl), (M-12033, CH.sub.3,
CH.sub.3, H, cyclohexylmethyl, F), (M-12034, CH.sub.3, CH.sub.3, H,
cyclohexylmethyl, CF.sub.3), (M-12035, CH.sub.3, CH.sub.3, H,
cyclohexylmethyl, Br), (M-12036, CH.sub.3, CH.sub.3, H,
cyclohexylmethyl, CH.sub.3), (M-12037, CH.sub.3, CH.sub.3, F, H,
H), (M-12038, CH.sub.3, CH.sub.3, F, H, Cl), (M-12039, CH.sub.3,
CH.sub.3, F, H, F), (M-12040, CH.sub.3, CH.sub.3, F, H, CF.sub.3),
(M-12041, CH.sub.3, CH.sub.3, F, H, Br), (M-12042, CH.sub.3,
CH.sub.3, F, H, CH.sub.3), (M-12043, CH.sub.3, CH.sub.3, F, F, H),
(M-12044, CH.sub.3, CH.sub.3, F, F, Cl), (M-12045, CH.sub.3,
CH.sub.3, F, F, F), (M-12046, CH.sub.3, CH.sub.3, F, F, CF.sub.3),
(M-12047, CH.sub.3, CH.sub.3, F, F, Br), (M-12048, CH.sub.3,
CH.sub.3, F, F, CH.sub.3), (M-12049, CH.sub.3, CH.sub.3, F, Cl, H),
(M-12050, CH.sub.3, CH.sub.3, F, Cl, Cl), (M-12051, CH.sub.3,
CH.sub.3, F, Cl, F), (M-12052, CH.sub.3, CH.sub.3, F, Cl,
CF.sub.3), (M-12053, CH.sub.3, CH.sub.3, F, Cl, Br), (M-12054,
CH.sub.3, CH.sub.3, F, Cl, CH.sub.3), (M-12055, CH.sub.3, CH.sub.3,
F, CH.sub.3, H), (M-12056, CH.sub.3, CH.sub.3, F, CH.sub.3, Cl),
(M-12057, CH.sub.3, CH.sub.3, F, CH.sub.3, F), (M-12058, CH.sub.3,
CH.sub.3, F, CH.sub.3, CF.sub.3), (M-12059, CH.sub.3, CH.sub.3, F,
CH.sub.3, Br), (M-12060, CH.sub.3, CH.sub.3, F, CH.sub.3,
CH.sub.3), (M-12061, CH.sub.3, CH.sub.3, F, Et, H), (M-12062,
CH.sub.3, CH.sub.3, F, Et, Cl), (M-12063, CH.sub.3, CH.sub.3, F,
Et, F), (M-12064, CH.sub.3, CH.sub.3, F, Et, CF.sub.3), (M-12065,
CH.sub.3, CH.sub.3, F, Et, Br), (M-12066, CH.sub.3, CH.sub.3, F,
Et, CH.sub.3), (M-12067, CH.sub.3, CH.sub.3, F, n-Pr, H), (M-12068,
CH.sub.3, CH.sub.3, F, n-Pr, Cl), (M-12069, CH.sub.3, CH.sub.3, F,
n-Pr, F), (M-12070, CH.sub.3, CH.sub.3, F, n-Pr, CF.sub.3),
(M-12071, CH.sub.3, CH.sub.3, F, n-Pr, Br), (M-12072, CH.sub.3,
CH.sub.3, F, n-Pr, CH.sub.3), (M-12073, CH.sub.3, CH.sub.3, F,
c-Pr, H), (M-12074, CH.sub.3, CH.sub.3, F, c-Pr, Cl), (M-12075,
CH.sub.3, CH.sub.3, F, c-Pr, F), (M-12076, CH.sub.3, CH.sub.3, F,
c-Pr, CF.sub.3), (M-12077, CH.sub.3, CH.sub.3, F, c-Pr, Br),
(M-12078, CH.sub.3, CH.sub.3, F, c-Pr, CH.sub.3), (M-12079,
CH.sub.3, CH.sub.3, F, i-Pr, H), (M-12080, CH.sub.3, CH.sub.3, F,
i-Pr, Cl), (M-12081, CH.sub.3, CH.sub.3, F, i-Pr, F), (M-12082,
CH.sub.3, CH.sub.3, F, i-Pr, CF.sub.3), (M-12083, CH.sub.3,
CH.sub.3, F, i-Pr, Br), (M-12084, CH.sub.3, CH.sub.3, F, i-Pr,
CH.sub.3), (M-12085, CH.sub.3, CH.sub.3, F, n-Bu, H), (M-12086,
CH.sub.3, CH.sub.3, F, n-Bu, Cl), (M-12087, CH.sub.3, CH.sub.3, F,
n-Bu, F), (M-12088, CH.sub.3, CH.sub.3, F, n-Bu, CF.sub.3),
(M-12089, CH.sub.3, CH.sub.3, F, n-Bu, Br), (M-12090, CH.sub.3,
CH.sub.3, F, n-Bu, CH.sub.3), (M-12091, CH.sub.3, CH.sub.3, F,
i-Bu, H), (M-12092, CH.sub.3, CH.sub.3, F, i-Bu, Cl), (M-12093,
CH.sub.3, CH.sub.3, F, i-Bu, F), (M-12094, CH.sub.3, CH.sub.3, F,
i-Bu, CF.sub.3), (M-12095, CH.sub.3, CH.sub.3, F, i-Bu, Br),
(M-12096, CH.sub.3, CH.sub.3, F, i-Bu, CH.sub.3), (M-12097,
CH.sub.3, CH.sub.3, F, sec-Bu, H), (M-12098, CH.sub.3, CH.sub.3, F,
sec-Bu, Cl), (M-12099, CH.sub.3, CH.sub.3, F, sec-Bu, F), (M-12100,
CH.sub.3, CH.sub.3, F, sec-Bu, CF.sub.3), (M-12101, CH.sub.3,
CH.sub.3, F, sec-Bu, Br), (M-12102, CH.sub.3, CH.sub.3, F, sec-Bn,
CH.sub.3), (M-12103, CH.sub.3, CH.sub.3, F, n-Pen, H), (M-12104,
CH.sub.3, CH.sub.3, F, n-Pen, Cl), (M-12105, CH.sub.3, CH.sub.3, F,
n-Pen, F), (M-12106, CH.sub.3, CH.sub.3, F, n-Pen, CF.sub.3),
(M-12107, CH.sub.3, CH.sub.3, F, n-Pen, Br), (M-12108, CH.sub.3,
CH.sub.3, F, n-Pen, CH.sub.3), (M-12109, CH.sub.3, CH.sub.3, F,
c-Pen, H), (M-12110, CH.sub.3, CH.sub.3, F, c-Pen, Cl), (M-12111,
CH.sub.3, CH.sub.3, F, c-Pen, F), (M-12112, CH.sub.3, CH.sub.3, F,
c-Pen, CF.sub.3), (M-12113, CH.sub.3, CH.sub.3, F, c-Pen, Br),
(M-12114, CH.sub.3, CH.sub.3, F, c-Pen, CH.sub.3), (M-12115,
CH.sub.3, CH.sub.3, F, n-Hex, H), (M-12116, CH.sub.3, CH.sub.3, F,
n-Hex, Cl), (M-12117, CH.sub.3, CH.sub.3, F, n-Hex, F), (M-12118,
CH.sub.3, CH.sub.3, F, n-Hex, CF.sub.3), (M-12119, CH.sub.3,
CH.sub.3, F, n-Hex, Br), (M-12120, CH.sub.3, CH.sub.3, F, n-Hex,
CH.sub.3), (M-12121, CH.sub.3, CH.sub.3, F, c-Hex, H), (M-12122,
CH.sub.3, CH.sub.3, F, c-Hex, Cl), (M-12123, CH.sub.3, CH.sub.3, F,
c-Hex, F), (M-12124, CH.sub.3, CH.sub.3, F, c-Hex, CF.sub.3),
(M-12125, CH.sub.3, CH.sub.3, F, c-Hex, Br), (M-12126, CH.sub.3,
CH.sub.3, F, c-Hex, CH.sub.3), (M-12127, CH.sub.3, CH.sub.3, F, OH,
H), (M-12128, CH.sub.3, CH.sub.3, F, OH, Cl), (M-12129, CH.sub.3,
CH.sub.3, F, OH, F), (M-12130, CH.sub.3, CH.sub.3, F, OH,
CF.sub.3), (M-12131, CH.sub.3, CH.sub.3, F, OH, Br), (M-12132,
CH.sub.3, CH.sub.3, F, OH, CH.sub.3), (M-12133, CH.sub.3, CH.sub.3,
F, EtO, H), (M-12134, CPIs, CH.sub.3, F, EtO, Cl), (M-12135,
CH.sub.3, CH.sub.3, F, EtO, F), (M-12136, CH.sub.3, CH.sub.3, F,
EtO, CF.sub.3), (M-12137, CH.sub.3, CH.sub.3, F, EtO, Br),
(M-12138, CH.sub.3, CH.sub.3, F, EtO, CH.sub.3), (M-12139,
CH.sub.3, CH.sub.3, F, n-PrO, H), (M-12140, CH.sub.3, CH.sub.3, F,
n-PrO, Cl), (M-12141, CH.sub.3, CH.sub.3, F, n-PrO, F), (M-12142,
CH.sub.3, CH.sub.3, F, n-PrO, CF.sub.3), (M-12143, CH.sub.3,
CH.sub.3, F, n-PrO, Br), (M-12144, CH.sub.3, CH.sub.3, F, n-PrO,
CH.sub.3), (M-12145, CH.sub.3, CH.sub.3, F, PhO, H), (M-12146,
CH.sub.3, CH.sub.3, F, PhO, Cl), (M-12147, CH.sub.3, CH.sub.3, F,
PhO, F), (M-12148, CH.sub.3, CH.sub.3, F, PhO, CF.sub.3), (M-12149,
CH.sub.3, CH.sub.3, F, PhO, Br), (M-12150, CH.sub.3, CH.sub.3, F,
PhO, CH.sub.3), (M-12151, CH.sub.3, CH.sub.3, F, BnO, H), (M-12152,
CH.sub.3, CH.sub.3(F, BnO, Cl), (M-12153, CH.sub.3, CH.sub.3, F,
BnO, F), (M-12154, CH.sub.3, CH.sub.3, F, BnO, CF.sub.3), (M-12155,
CH.sub.3, CH.sub.3, F, BnO, Br), (M-12156, CH.sub.3, CH.sub.3, F,
BnO, CH.sub.3), (M-12157, CH.sub.3, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, H), (M-12158, CH.sub.3, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, Cl), (M-12159, CH.sub.3, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, F), (M-12160, CH.sub.3, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-12161, CH.sub.3, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, Br), (M-12162, CH.sub.3, CH.sub.3, F,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-12163, CH.sub.3, CH.sub.3, F,
CF.sub.3O, H), (M-12164, CH.sub.3, CH.sub.3, F, CF.sub.3O, Cl),
(M-12165, CH.sub.3, CH.sub.3, F, CF.sub.3O, F), (M-12166, CH.sub.3,
CH.sub.3, F, CF.sub.30, CF.sub.3), (M-12167, CH.sub.3, CH.sub.3, F,
CF.sub.3O, Br), (M-12168, CH.sub.3, CH.sub.3, F, CF.sub.3O,
CH.sub.3), (M-12169, CH.sub.3, CH.sub.3, F, Ph, H), (M-12170,
CH.sub.3, CH.sub.3, F, Ph, Cl), (M-12171, CH.sub.3, CH.sub.3, F,
Ph, F), (M-12172, CH.sub.3, CH.sub.3, F, Ph, CF.sub.3), (M-12173,
CH.sub.3, CH.sub.3, F, Ph, Br), (M-12174, CH.sub.3, CH.sub.3, F,
Ph, CH.sub.3), (M-12175, CH.sub.3, CH.sub.3, F, 4-F-Ph, H),
(M-12176, CH.sub.3, CH.sub.3, F, 4-F-Ph, Cl), (M-12177, CH.sub.3,
CH.sub.3, F, 4-F-Ph, F), (M-12178, CH.sub.3, CH.sub.3, F, 4-F-Ph,
CF.sub.3), (M-12179, CH.sub.3, CH.sub.3, F, 4-F-Ph, Br), (M-12180,
CH.sub.3, CH.sub.3, F, 4-F-Ph, CH.sub.3), (M-12181, CH.sub.3,
CH.sub.3, F, 4-CF.sub.3-Ph, H), (M-12182, CH.sub.3, CH.sub.3, F,
4-CF.sub.3-Ph, Cl), (M-12183, CH.sub.3, CH.sub.3, F, 4-CF.sub.3-Ph,
F), (M-12184, CH.sub.3, CH.sub.3, F, 4-CF.sub.3-Ph, CF.sub.3),
(M-12185, CH.sub.3, CH.sub.3, F, 4-CF.sub.3-Ph, Br), (M-12186,
CH.sub.3, CH.sub.3, F, 4-CF.sub.3-Ph, CH.sub.3), (M-12187,
CH.sub.3, CH.sub.3, F, 4-(Me).sub.2N-Ph, H), (M-12188, CH.sub.3,
CH.sub.3, F, 4-(Me).sub.2N-Ph, Cl), (M-12189, CH.sub.3, CH.sub.3,
F, 4-(Me).sub.2N-Ph, F), (M-12190, CH.sub.3, CH.sub.3, F,
4-(Me).sub.2N-Ph, CF.sub.3), (M-12191, CH.sub.3, CH.sub.3, F,
4-(Me).sub.2N-Ph, Br), (M-12192, CH.sub.3, CH.sub.3, F,
4-(Me).sub.2N-Ph, CH.sub.3), (M-12193, CH.sub.3, CH.sub.3, F,
4-OH-Ph, H), (M-12194, CH.sub.3, CH.sub.3, F, 4-OH-Ph, Cl),
(M-12195, CH.sub.3, CH.sub.3, F, 4-OH-Ph, F), (M-12196, CH.sub.3,
CH.sub.3, F, 4-OH-Ph, CF.sub.3), (M-12197, CH.sub.3, CH.sub.3, F,
4-OH-Ph, Br), (M-12198, CH.sub.3, CH.sub.3, F, 4-OH-Ph, CH.sub.3),
(M-12199, CH.sub.3, CH.sub.3, F, 3,4-di-F-Ph, H), (M-12200,
CH.sub.3, CH.sub.3, F, 3,4-di-F-Ph, Cl), (M-12201, CH.sub.3,
CH.sub.3, F, 3,4-di-F-Ph, F), (M-12202, CH.sub.3, CH.sub.3, F,
3,4-di-F-Ph, CF.sub.3), (M-12203, CH.sub.3, CH.sub.3, F,
3,4-di-F-Ph, Br), (M-12204, CH.sub.3, CH.sub.3, F, 3,4-di-F-Ph,
CH.sub.3), (M-12205, CH.sub.3, CH.sub.3, F, 4-COOH-Ph, H),
(M-12206, CH.sub.3, CH.sub.3, F, 4-COOH-Ph, Cl), (M-12207,
CH.sub.3, CH.sub.3, F, 4-COOH-Ph, F), (M-12208, CH.sub.3, CH.sub.3,
F, 4-COOH-Ph, CF.sub.3), (M-12209, CH.sub.3, CH.sub.3, F,
4-COOH-Ph, Br), (M-12210, CH.sub.3, CH.sub.3, F, 4-COOH-Ph,
CH.sub.3), (M-12211, CH.sub.3, CH.sub.3, F, Bn, H), (M-12212,
CH.sub.3, CH.sub.3, F, Bn, Cl), (M-12213, CH.sub.3, CH.sub.3, F,
Bn, F), (M-12214, CH.sub.3, CH.sub.3, F, Bn, CF.sub.3), (M-12215,
CH.sub.3, CH.sub.3, F, Bn, Br), (M-12216, CH.sub.3, CH.sub.3, F,
Bn, CH.sub.3), (M-12217, CH.sub.3, CH.sub.3, F, 4-F-Bn, H),
(M-12218, CH.sub.3, CH.sub.3, F, 4-F-Bn, Cl), (M-12219, CH.sub.3,
CH.sub.3, F, 4-F-Bn, F), (M-12220, CH.sub.3, CH.sub.3, F, 4-F-Bn,
CF.sub.3), (M-12221, CH.sub.3, CH.sub.3, F, 4-F-Bn, Br), (M-12222,
CH.sub.3, CH.sub.3, F, 4-F-Bn, CH.sub.3), (M-12223, CH.sub.3,
CH.sub.3, F, 2-Py, H), (M-12224, CH.sub.3, CH.sub.3, F, 2-Py, Cl),
(M-12225, CH.sub.3, CH.sub.3, F, 2-Py, F), (M-12226, CH.sub.3,
CH.sub.3, F, 2-Py, CF.sub.3), (M-12227, CH.sub.3, CH.sub.3, F,
2-Py, Br), (M-12228, CH.sub.3, CH.sub.3, F, 2-Py, CH.sub.3),
(M-12229, CH.sub.3, CH.sub.3, F, 3-Py, H), (M-12230, CH
.sub.3, CH.sub.3, F, 3-Py, Cl), (M-12231, CH.sub.3, CH.sub.3, F,
3-Py, F), (M-12232, CH.sub.3, CH.sub.3, F, 3-Py, CF.sub.3),
(M-12233, CH.sub.3, CH.sub.3, F, 3-Py, Br), (M-12234, CH.sub.3,
CH.sub.3, F, 3-Py, CH.sub.3), (M-12235, CH.sub.3, CH.sub.3, F,
4-Py, H), (M-12236, CH.sub.3, CH.sub.3, F, 4-Py, Cl), (M-12237,
CH.sub.3, CH.sub.3, F, 4-Py, F), (M-12238, CH.sub.3, CH.sub.3, F,
4-Py, CF.sub.3), (M-12239, CH.sub.3, CH.sub.3, F, 4-Py, Br),
(M-12240, CH.sub.3, CH.sub.3, F, 4-Py, CH.sub.3), (M-12241,
CH.sub.3, CH.sub.3, F, 2-Th, H), (M-12242, CH.sub.3, CH.sub.3, F,
2-Th, Cl), (M-12243, CH.sub.3, CH.sub.3, F, 2-Th, F), (M-12244,
CH.sub.3, CH.sub.3, F, 2-Th, CF.sub.3), (M-12245, CH.sub.3,
CH.sub.3, F, 2-Th, Br), (M-12246, CH.sub.3, CH.sub.3, F, 2-Th,
CH.sub.3), (M-12247, CH.sub.3, CH.sub.3, F, 3-Th, H), (M-12248,
CH.sub.3, CH.sub.3, F, 3-Th, Cl), (M-12249, CH.sub.3, CH.sub.3, F,
3-Th, F), (M-12250, CH.sub.3, CH.sub.3, F, 3-Th, CF.sub.3),
(M-12251, CH.sub.3, CH.sub.3, F, 3-Th, Br), (M-12252, CH.sub.3,
CH.sub.3, F, 3-Th, CH.sub.3), (M-12253, CH.sub.3, CH.sub.3, F,
pyrrazol-2-yl, H), (M-12254, CH.sub.3, CH.sub.3, F, pyrrazol-2-yl,
Cl), (M-12255, CH.sub.3, CH.sub.3, F, pyrrazol-2-yl, F), (M-12256,
CH.sub.3, CH.sub.3, F, pyrrazol-2-yl, CF.sub.3), (M-12257,
CH.sub.3, CH.sub.3, F, pyrrazol-2-yl, Br), (M-12258, CH.sub.3,
CH.sub.3, F, pyrrazol-2-yl, CH.sub.3), (M-12259, CH.sub.3,
CH.sub.3, F, pyrrazol-3-yl, H), (M-12260, CH.sub.3, CH.sub.3, F,
pyrrazol-3-yl, Cl), (M-12261, CH.sub.3, CH.sub.3, F, pyrrazol-3-yl,
F), (M-12262, CH.sub.3, CH.sub.3, F, pyrrazol-3-yl, CF.sub.3),
(M-12263, CH.sub.3, CH.sub.3, F, pyrrazol-3-yl, Br), (M-12264,
CH.sub.3, CH.sub.3, F, pyrrazol-3-yl, CH.sub.3), (M-12265,
CH.sub.3, CH.sub.3, F, pyrimidin-2-yl, H), (M-12266, CH.sub.3,
CH.sub.3, F, pyrimidin-2-yl, Cl), (M-12267, CH.sub.3, CH.sub.3, F,
pyrimidin-2-yl, F), (M-12268, CH.sub.3, CH.sub.3, F,
pyrimidin-2-yl, CF.sub.3), (M-12269, CH.sub.3, CH.sub.3, F,
pyrimidin-2-yl, Br), (M-12270, CH.sub.3, CH.sub.3, F,
pyrimidin-2-yl, CH.sub.3), (M-12271, CH.sub.3, CH.sub.3, F,
pyrimidin-4-yl, H), (M-12272, CH.sub.3, CH.sub.3, F,
pyrimidin-4-yl, Cl), (M-12273, CH.sub.3, CH.sub.3, F,
pyrimidin-4-yl, F), (M-12274, CH.sub.3, CH.sub.3, F,
pyrimidin-4-yl, CF.sub.3), (M-12275, CH.sub.3, CH.sub.3, F,
pyrimidin-4-yl, Br), (M-12276, CH.sub.3, CH.sub.3, F,
pyrimidin-4-yl, CH.sub.3), (M-12277, CH.sub.3, CH.sub.3, F,
pyrimidin-5-yl, H), (M-12278, CH.sub.3, CH.sub.3, F,
pyrimidin-5-yl, Cl), (M-12279, CH.sub.3, CH.sub.3, F,
pyrimidin-5-yl, F), (M-12280, CH.sub.3, CH.sub.3, F,
pyrimidin-5-yl, CF.sub.3), (M-12281, CH.sub.3, CH.sub.3, F,
pyrimidin-5-yl, Br), (M-12282, CH.sub.3, CH.sub.3, F,
pyrimidin-5-yl, CH.sub.3), (M-12283, CH.sub.3, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.3, H), (M-12284, CH.sub.3, CH.sub.3, F,
HOOCCH.sub.3CH.sub.2CH.sub.3, Cl), (M-12285, CH.sub.3, CH.sub.3, F,
HOOCCH.sub.3CH.sub.2CH.sub.2, F), (M-12286, CH.sub.3, CH.sub.3, F,
HOOCCH.sub.3CH.sub.2CH.sub.2, CF.sub.3), (M-12287, CH.sub.3,
CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-12288, CH.sub.3,
CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-12289,
CH.sub.3, CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-12290, CH.sub.3, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-12291, CH.sub.3,
CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-12292,
CH.sub.3, CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-12293, CH.sub.3, CH.sub.3, F,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-12294, CH.sub.3,
CH.sub.3, F, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-12295, CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-12296,
CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-12297,
CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-12298,
CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.3, CF.sub.3), (M-12299,
CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-12300,
CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.3), (M-12301,
CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-12302, CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl), (M-12303,
CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-12304, CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-12305, CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-12306, CH.sub.3, CH.sub.3, F,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-12307, CH.sub.3, CH.sub.3, F, MeOCH.sub.2, H), (M-12308,
CH.sub.3, CH.sub.3, F, MeOCH.sub.2, Cl), (M-12309, CH.sub.3,
CH.sub.3, F, MeOCH.sub.2, F), (M-12310, CH.sub.3, CH.sub.3, F,
MeOCH.sub.2, CF.sub.3), (M-12311, CH.sub.3, CH.sub.3, F,
MeOCH.sub.2, Br), (M-12312, CH.sub.3, CH.sub.3, F, MeOCH.sub.2,
CH.sub.3), (M-12313, CH.sub.3, CH.sub.3, F, EtOCH.sub.2, H),
(M-12314, CH.sub.3, CH.sub.3, F, EtOCH.sub.2, Cl), (M-12315,
CH.sub.3, CH.sub.3, F, EtOCH.sub.2, F), (M-12316, CH.sub.3,
CH.sub.3, F, EtOCH.sub.2, CF.sub.3), (M-12317, CH.sub.3, CH.sub.3,
F, EtOCH.sub.2, Br), (M-12318, CH.sub.3, CH.sub.3, F, EtOCH.sub.2,
CH.sub.3), (M-12319, CH.sub.3, CH.sub.3, F, EtOCH.sub.2CH.sub.2,
H), (M-12320, CH.sub.3, CH.sub.3, F, EtOCH.sub.2CH.sub.2, Cl),
(M-12321, CH.sub.3, CH.sub.3, F, EtOCH.sub.2CH.sub.2, F), (M-12322,
CH.sub.3, CH.sub.3, F, EtOCH.sub.2CH.sub.2, CF.sub.3), (M-12323,
CH.sub.3, CH.sub.3, F, EtOCH.sub.2CH.sub.2, Br), (M-12324,
CH.sub.3, CH.sub.3, F, EtOCH.sub.2CH.sub.2, CH.sub.3), (M-12325,
CH.sub.3, CH.sub.3, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H),
(M-12326, CH.sub.3, CH.sub.3, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-12327, CH.sub.3,
CH.sub.3, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-12328,
CH.sub.3, CH.sub.3, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CF.sub.3), (M-12329, CH.sub.3, CH.sub.3, F,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-12330, CH.sub.3,
CH.sub.3, F, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-12331, CH.sub.3, CH.sub.3, F, MeOCH.sub.2CH.sub.2, H), (M-12332,
CH.sub.3, CH.sub.3, F, MeOCH.sub.2CH.sub.2, Cl), (M-12333,
CH.sub.3, CH.sub.3, F, MeOCH.sub.2CH.sub.2, F), (M-12334, CH.sub.3,
CH.sub.3, F, MeOCH.sub.2CH.sub.2, CF.sub.3), (M-12335, CH.sub.3,
CH.sub.3, F, MeOCH.sub.2CH.sub.2, Br), (M-12336, CH.sub.3,
CH.sub.3, F, MeOCH.sub.2CH.sub.2, CH.sub.3), (M-12337, CH.sub.3,
CH.sub.3, F, HOCH.sub.2, H), (M-12338, CH.sub.3, CH.sub.3, F,
HOCH.sub.2, Cl), (M-12339, CH.sub.3, CH.sub.3, F, HOCH.sub.2, F),
(M-12340, CH.sub.3, CH.sub.3, F, HOCH.sub.2, CF.sub.3), (M-12341,
CH.sub.3, CH.sub.3, F, HOCH.sub.2, Br), (M-12342, CH.sub.3,
CH.sub.3, F, HOCH.sub.2, CH.sub.3), (M-12343, CH.sub.3, CH.sub.3,
F, HOCH.sub.2CH.sub.2, H), (M-12344, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2, Cl), (M-12345, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2, F), (M-12346, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2, CF.sub.3), (M-12347, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2, Br), (M-12348, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-12349, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-12350, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-12351, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.3, F), (M-12352, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-12353, CH.sub.3,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-12354, CH.sub.3,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-12355,
CH.sub.3, CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-12356, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-12357, CH.sub.3,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-12358,
CH.sub.3, CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-12359, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-12360, CH.sub.3,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-12361, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-12362, CH.sub.3,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl),
(M-12363, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-12364, CH.sub.3,
CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-12365, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.3CH.sub.3, Br), (M-12366,
CH.sub.3, CH.sub.3, F, HOCH.sub.2CH.sub.2CH.sub.3CH.sub.2CH.sub.2,
CH.sub.3), (M-12367, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-12368, CH.sub.3,
CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-12369,
CH.sub.3, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-12370, CH.sub.3, CH.sub.3, F,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-12371, CH.sub.3,
CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-12372,
CH.sub.3, CH.sub.3, F, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CH.sub.3), (M-12373, CH.sub.3, CH.sub.3, F, (Me).sub.2N, H),
(M-12374, CH.sub.3, CH.sub.3, F, (Me).sub.2N, Cl), (M-12375,
CH.sub.3, CH.sub.3, F, (Me).sub.2N, F), (M-12376, CH.sub.3,
CH.sub.3, F, (Me).sub.2N, CF.sub.3), (M-12377, CH.sub.3, CH.sub.3,
F, (Me).sub.2N, Br), (M-12378, CH.sub.3, CH.sub.3, F, (Me).sub.2N,
CH.sub.3), (M-12379, CH.sub.3, CH.sub.3, F, piperidin-4-yl-methyl,
H), (M-12380, CH.sub.3, CH.sub.3, F, piperidin-4-yl-methyl, Cl),
(M-12381, CH.sub.3, CH.sub.3, F, piperidin-4-yl-methyl, F),
(M-12382, CH.sub.3, CH.sub.3, F, piperidin-4-yl-methyl, CF.sub.3),
(M-12383, CH.sub.3, CH.sub.3, F, piperidin-4-yl-methyl, Br),
(M-12384, CH.sub.3, CH.sub.3, F, piperidin-4-yl-methyl, CH.sub.3),
(M-12385, CH.sub.3, CH.sub.3, F, cyclohexylmethyl, H), (M-12386,
CH.sub.3, CH.sub.3, F, cyclohexylmethyl, Cl), (M-12387, CH.sub.3,
CH.sub.3, F, cyclohexylmethyl, F), (M-12388, CH.sub.3, CH.sub.3, F,
cyclohexylmethyl, CF.sub.3), (M-12389, CH.sub.3, CH.sub.3, F,
cyclohexylmethyl, Br), (M-12390, CH.sub.3, CH.sub.3, F,
cyclohexylmethyl, CH.sub.3), (M-12391, CH.sub.3, CH.sub.3, Cl, H,
H), (M-12392, CH.sub.3, CH.sub.3, Cl, H, Cl), (M-12393, CH.sub.3,
CH.sub.3, Cl, H, F), (M-12394, CH.sub.3, CH.sub.3, Cl, H,
CF.sub.3), (M-12395, CH.sub.3, CH.sub.3, Cl, H, Br), (M-12396,
CH.sub.3, CH.sub.3, Cl, H, CH.sub.3), (M-12397, CH.sub.3, CH.sub.3,
Cl, F, H), (M-12398, CH.sub.3, CH.sub.3, Cl, F, Cl), (M-12399,
CH.sub.3, CH.sub.3, Cl, F, F), (M-12400, CH.sub.3, CH.sub.3, Cl, F,
CF.sub.3), (M-12401, CH.sub.3, CH.sub.3, Cl, F, Br), (M-12402,
CH.sub.3, CH.sub.3, Cl, F, CH.sub.3), (M-12403, CH.sub.3, CH.sub.3,
Cl, Cl, H), (M-12404, CH.sub.3, CH.sub.3, Cl, Cl, Cl), (M-12405,
CH.sub.3, CH.sub.3, Cl, Cl, F), (M-12406, CH.sub.3, CH.sub.3, Cl,
Cl, CF.sub.3), (M-12407, CH.sub.3, CH.sub.3, Cl, Cl, Br), (M-12408,
CH.sub.3, CH.sub.3, Cl, Cl, CH.sub.3), (M-12409, CH.sub.3,
CH.sub.3, Cl, CH.sub.3, H), (M-12410, CH.sub.3, CH.sub.3, Cl,
CH.sub.3, Cl), (M-12411, CH.sub.3, CH.sub.3, Cl, CH.sub.3, F),
(M-12412, CH.sub.3, CH.sub.3, Cl, CH.sub.3, CF.sub.3), (M-12413,
CH.sub.3, CH.sub.3, Cl, CH.sub.3, Br), (M-12414, CH.sub.3,
CH.sub.3, Cl, CH.sub.3, CH.sub.3), (M-12415, CH.sub.3, CH.sub.3,
Cl, Et, H), (M-12416, CH.sub.3, CH.sub.3, Cl, Et, Cl), (M-12417,
CH.sub.3, CH.sub.3, Cl, Et, F), (M-12418, CH.sub.3, CH.sub.3, Cl,
Et, CF.sub.3), (M-12419, CH.sub.3, CH.sub.3, Cl, Et, Br), (M-12420,
CH.sub.3, CH.sub.3, Cl, Et, CH.sub.3), (M-12421, CH.sub.3,
CH.sub.3, Cl, n-Pr, H), (M-12422, CH.sub.3, CH.sub.3, Cl, n-Pr,
Cl), (M-12423, CH.sub.3, CH.sub.3, Cl, n-Pr, F), (M-12424,
CH.sub.3, CH.sub.3, Cl, n-Pr, CF.sub.3), (M-12425, CH.sub.3,
CH.sub.3, Cl, n-Pr, Br), (M-12426, CH.sub.3, CH.sub.3, Cl, n-Pr,
CH.sub.3), (M-12427, CH.sub.3, CH.sub.3, Cl, c-Pr, H), (M-12428,
CH.sub.3, CH.sub.3, Cl, c-Pr, Cl), (M-12429, CH.sub.3, CH.sub.3,
Cl, c-Pr, F), (M-12430, CH.sub.3, CH.sub.3, Cl, c-Pr, CF.sub.3),
(M-12431, CH.sub.3, CH.sub.3, Cl, c-Pr, Br), (M-12432, CH.sub.3,
CH.sub.3, Cl, c-Pr, CH.sub.3), (M-12433, CH.sub.3, CH.sub.3, Cl,
i-Pr, H), (M-12434, CH.sub.3, CH.sub.3, Cl, i-Pr, Cl), (M-12435,
CH.sub.3, CH.sub.3, Cl, i-Pr, F), (M-12436, CH.sub.3, CH.sub.3, Cl,
i-Pr, CF.sub.3), (M-12437, CH.sub.3, CH.sub.3, Cl, i-Pr, Br),
(M-12438, CH.sub.3, CH.sub.3, Cl, i-Pr, CH.sub.3), (M-12439,
CH.sub.3, CH.sub.3, Cl, n-Bu, H), (M-12440, CH.sub.3, CH.sub.3, Cl,
n-Bu, Cl), (M-12441, CH.sub.3, CH.sub.3, Cl, n-Bu, F), (M-12442,
CH.sub.3, CH.sub.3, Cl, n-Bu, CF.sub.3), (M-12443, CH.sub.3,
CH.sub.3, Cl, n-Bu, Br), (M-12444, CH.sub.3, CH.sub.3, Cl, n-Bu,
CH.sub.3), (M-12445, CH.sub.3, CH.sub.3, Cl, i-Bu, H), (M-12446,
CH.sub.3, CH.sub.3, Cl, i-Bu, Cl), (M-12447, CH.sub.3, CH.sub.3,
Cl, i-Bu, F), (M-12448, CH.sub.3, CH.sub.3, Cl, i-Bu, CF.sub.3),
(M-12449, CH.sub.3, CH.sub.3, Cl, i-Bu, Br), (M-12450, CH.sub.3,
CH.sub.3, Cl, i-Bn, CH.sub.3), (M-12451, CH.sub.3, CH.sub.3, Cl,
sec-Bu, H), (M-12452, CH.sub.3, CH.sub.3, Cl, sec-Bu, Cl),
(M-12453, CH.sub.3, CH.sub.3, Cl, sec-Bu, F), (M-12454, CH.sub.3,
CH.sub.3, Cl, sec-Bu, CF.sub.3), (M-12455, CH.sub.3, CH.sub.3, Cl,
sec-Bu, Br), (M-12456, CH.sub.3, CH.sub.3, Cl, sec-Bu, CH.sub.3),
(M-12457, CH.sub.3, CH.sub.3, Cl, n-Pen, H), (M-12458, CH.sub.3,
CH.sub.3, Cl, n-Pen, Cl), (M-12459, CH.sub.3, CH.sub.3, Cl, n-Pen,
F), (M-12460, CH.sub.3, CH.sub.3, Cl, n-Pen, CF.sub.3), (M-12461,
CH.sub.3, CH.sub.3, Cl, n-Pen, Br), (M-12462, CH.sub.3, CH.sub.3,
Cl, n-Pen, CH.sub.3), (M-12463, CH.sub.3, CH.sub.3, Cl, c-Pen, H),
(M-12464, CH.sub.3, CH.sub.3, Cl, c-Pen, Cl), (M-12465, CH.sub.3,
CH.sub.3, Cl, c-Pen, F), (M-12466, CH.sub.3, CH.sub.3, Cl, c-Pen,
CF.sub.3), (M-12467, CH.sub.3, CH.sub.3, Cl, c-Pen, Br), (M-12468,
CH.sub.3, CH.sub.3, Cl, c-Pen, CH.sub.3), (M-12469, CH.sub.3,
CH.sub.3, Cl, n-Hex, H), (M-12470, CH.sub.3, CH.sub.3, Cl, n-Hex,
Cl), (M-12471, CH.sub.3, CH.sub.3, Cl, n-Hex, F), (M-12472,
CH.sub.3, CH.sub.3, Cl, h-Hex, CF.sub.3), (M-12473, CH.sub.3,
CH.sub.3, Cl, n-Hex, Br), (M-12474, CH.sub.3, CH.sub.3, Cl, n-Hex,
CH.sub.3), (M-12475, CH.sub.3, CH.sub.3, Cl, c-Hex, H), (M-12476,
CH.sub.3, CH.sub.3, Cl, c-Hex, Cl), (M-12477, CH.sub.3, CH.sub.3,
Cl, c-Hex, F), (M-12478, CH.sub.3, CH.sub.3, Cl, c-Hex, CF.sub.3),
(M-12479, CH.sub.3, CH.sub.3, Cl, c-Hex, Br), (M-12480, CH.sub.3,
CH.sub.3, Cl, c-Hex, CH.sub.3), (M-12481, CH.sub.3, CH.sub.3, Cl,
OH, H), (M-12482, CH.sub.3, CH.sub.3, Cl, OH, Cl), (M-12483,
CH.sub.3, CH.sub.3, Cl, OH, F), (M-12484, CH.sub.3, CH.sub.3, Cl,
OH, CF.sub.3), (M-12485, CH.sub.3, CH.sub.3, Cl, OH, Br), (M-12486,
CH.sub.3, CH.sub.3, Cl, OH, CH.sub.3), (M-12487, CH.sub.3,
CH.sub.3, Cl, EtO, H), (M-12488, CH.sub.3, CH.sub.3, Cl, EtO, Cl),
(M-12489, CH.sub.3, CH.sub.3, Cl, EtO, F), (M-12490, CH.sub.3,
CH.sub.3, Cl, EtO, CF.sub.3), (M-12491, CH.sub.3, CH.sub.3, Cl,
EtO, Br), (M-12492, CH.sub.3, CH.sub.3, Cl, EtO, CH.sub.3),
(M-12493, CH.sub.3, CH.sub.3, Cl, n-PrO, H), (M-12494, CH.sub.3,
CH.sub.3, Cl, n-PrO, Cl), (M-12495, CH.sub.3, CH.sub.3, Cl, n-PrO,
F), (M-12496, CH.sub.3, CH.sub.3, Cl, n-PrO, CF.sub.3), (M-12497,
CH.sub.3, CH.sub.3, Cl, n-PrO, Br), (M-12498, CH
.sub.3, CH.sub.3, Cl, n-PrO, CH.sub.3), (M-12499, CH.sub.3,
CH.sub.3, Cl, PhO, H), (M-12500, CH.sub.3, CH.sub.3, Cl, PhO, Cl),
(M-12501, CH.sub.3, CH.sub.3, Cl, PhO, F), (M-12502, CH.sub.3,
CH.sub.3, Cl, PhO, CF.sub.3), (M-12503, CH.sub.3, CH.sub.3, Cl,
PhO, Br), (M-12504, CH.sub.3, CH.sub.3, Cl, PhO, CH.sub.3),
(M-12505, CH.sub.3, CH.sub.3) Cl, BnO, H), (M-12506, CH.sub.3,
CH.sub.3, Cl, BnO, Cl), (M-12507, CH.sub.3, CH.sub.3, Cl, BnO, F),
(M-12508, CH.sub.3, CH.sub.3, Cl, BnO, CF.sub.3), (M-12509,
CH.sub.3, CH.sub.3, Cl, BnO, Br), (M-12510, CH.sub.3, CH.sub.3, Cl,
BnO, CH.sub.3), (M-12511, CH.sub.3, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, H), (M-12512, CH.sub.3, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, Cl), (M-12513, CH.sub.3, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, F), (M-12514, CH.sub.3, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, CF.sub.3), (M-12515, CH.sub.3, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, Br), (M-12516, CH.sub.3, CH.sub.3, Cl,
PhCH.sub.2CH.sub.2O, CH.sub.3), (M-12517, CH.sub.3, CH.sub.3, Cl,
CF.sub.3O, H), (M-12518, CH.sub.3, CH.sub.3, Cl, CF.sub.3O, Cl),
(M-12519, CH.sub.3, CH.sub.3, Cl, CF.sub.3O, F), (M-12520,
CH.sub.3, CH.sub.3, Cl, CF.sub.3O, CF.sub.3), (M-12521, CH.sub.3,
CH.sub.3, Cl, CF.sub.3O, Br), (M-12622, CH.sub.3, CH.sub.3, Cl,
CF.sub.3O, CH.sub.3), (M-12523, CH.sub.3, CH.sub.3, Cl, Ph, H),
(M-12524, CH.sub.3, CH.sub.3, Cl, Ph, Cl), (M-12525, CH.sub.3,
CH.sub.3, Cl, Ph, F), (M-12526, CH.sub.3, CH.sub.3, Cl, Ph,
CF.sub.3), (M-12527, CH.sub.3, CH.sub.3, Cl, Ph, Br), (M-12528,
CH.sub.3, CH.sub.3, Cl, Ph, CH.sub.3), (M-12529, CH.sub.3,
CH.sub.3, Cl, 4-F-Ph, H), (M-12530, CH.sub.3, CH.sub.3, Cl, 4-F-Ph,
Cl), (M-12531, CH.sub.3, CH.sub.3, Cl, 4-F-Ph, F), (M-12632,
CH.sub.3, CH.sub.3, Cl, 4-F-Ph, CF.sub.3), (M-12533, CH.sub.3,
CH.sub.3, Cl, 4-F-Ph, Br), (M-12534, CH.sub.3, CH.sub.3, Cl,
4-F-Ph, CH.sub.3), (M-12535, CH.sub.3, CH.sub.3, Cl, 4-CF.sub.3-Ph,
H), (M-12536, CH.sub.3, CH.sub.3, Cl, 4-CF.sub.3-Ph, Cl), (M-12537,
CH.sub.3, CH.sub.3, Cl, 4-CF.sub.3-Ph, F), (M-12538, CH.sub.3,
CH.sub.3, Cl, 4-CF.sub.3-Ph, CF.sub.3), (M-12539, CH.sub.3,
CH.sub.3, Cl, 4-CF.sub.3-Ph, Br), (M-12540, CH.sub.3, CH.sub.3, Cl,
4-CF.sub.3-Ph, CH.sub.3), (M-12541, CH.sub.3, CH.sub.3, Cl,
4-(Me).sub.2N-Ph, H), (M-12542, CH.sub.3, CH.sub.3, Cl,
4-(Me).sub.2N-Ph, Cl), (M-12543, CH.sub.3, CH.sub.3, Cl,
4-(Me).sub.2N-Ph, F), (M-12544, CH.sub.3, CH.sub.3, Cl,
4-(Me).sub.2N-Ph, CF.sub.3), (M-12545, CH.sub.3, CH.sub.3, Cl,
4-(Me).sub.2N-Ph, Br), (M-12546, CH.sub.3, CH.sub.3, Cl,
4-(Me).sub.2N-Ph, CH.sub.3), (M-12547, CH.sub.3, CH.sub.3, Cl,
4-OH-Ph, H), (M-12548, CH.sub.3, CH.sub.3, Cl, 4-OH-Ph, Cl),
(M-12549, CH.sub.3, CH.sub.3, Cl, 4-OH-Ph, F), (M-12550, CH.sub.3,
CH.sub.3, Cl, 4-OH-Ph, CF.sub.3), (M-12551, CH.sub.3, CH.sub.3, Cl,
4-OH-Ph, Br), (M-12552, CH.sub.3, CH.sub.3, Cl, 4-OH-Ph, CH.sub.3),
(M-12553, CH.sub.3, CH.sub.3, Cl, 3,4-di-F-Ph, H), (M-12554,
CH.sub.3, CH.sub.3, Cl, 3,4-di-F-Ph, Cl), (M-12555, CH.sub.3,
CH.sub.3, Cl, 3,4-di-F-Ph, F), (M-12556, CH.sub.3, CH.sub.3, Cl,
3,4-di-F-Ph, CF.sub.3), (M-12557, CH.sub.3, CH.sub.3, Cl,
3,4-di-F-Ph, Br), (M-12558, CH.sub.3, CH.sub.3, Cl, 3,4-di-F-Ph,
CH.sub.3), (M-12559, CH.sub.3, CH.sub.3, Cl, 4-COOH-Ph, H),
(M-12560, CH.sub.3, CH.sub.3, Cl, 4-COOH-Ph, Cl), (M-12561,
CH.sub.3, CH.sub.3, Cl, 4-COOH-Ph, F), (M-12562, CH.sub.3,
CH.sub.3, Cl, 4-COOH-Ph, CF.sub.3), (M-12563, CH.sub.3, CH.sub.3,
Cl, 4-COOH-Ph, Br), (M-12564, CH.sub.3, CH.sub.3, Cl, 4-COOH-Ph,
CH.sub.3), (M-12565, CH.sub.3, CH.sub.3, Cl, Bn, H), (M-12566,
CH.sub.3, CH.sub.3, Cl, Bn, Cl), (M-12567, CH.sub.3, CH.sub.3, Cl,
Bn, F), (M-12568, CH.sub.3, CH.sub.3, Cl, Bn, CF.sub.3), (M-12569,
CH.sub.3, CH.sub.3, Cl, Bn, Br), (M-12570, CH.sub.3, CH.sub.3, Cl,
Bn, CH.sub.3), (M-12571, CH.sub.3, CH.sub.3, Cl, 4-F-Bn, H),
(M-12572, CH.sub.3, CH.sub.3, Cl, 4-F-Bn, Cl), (M-12573, CH.sub.3,
CH.sub.3, Cl, 4-F-Bn, F), (M-12574, CH.sub.3, CH.sub.3, Cl, 4-F-Bn,
CF.sub.3), (M-12575, CH.sub.3, CH.sub.3, Cl, 4-F-Bn, Br), (M-12576,
CPU, CH.sub.3, Cl, 4-F-Bn, CH.sub.3), (M-12577, CH.sub.3, CH.sub.3,
Cl, 2-Py, H), (M-12578, CH.sub.3, CH.sub.3, Cl, 2-Py, Cl),
(M-12579, CH.sub.3, CH.sub.3, Cl, 2-Py, F), (M-12580, CH.sub.3,
CH.sub.3, Cl, 2-Py, CF.sub.3), (M-12581, CH.sub.3, CH.sub.3, Cl,
2-Py, Br), (M-12582, CH.sub.3, CH.sub.3, Cl, 2-Py, CH.sub.3),
(M-12583, CH.sub.3, CH.sub.3, Cl, 3-Py, H), (M-12584, CH.sub.3,
CH.sub.3, Cl, 3-Py, Cl), (M-12585, CH.sub.3, CH.sub.3, Cl, 3-Py,
F), (M-12586, CH.sub.3, CH.sub.3, Cl, 3-Py, CF.sub.3), (M-12587,
CH.sub.3, CH.sub.3, Cl, 3-Py, Br), (M-12588, CH.sub.3, CH.sub.3,
Cl, 3-Py, CH.sub.3), (M-12589, CH.sub.3, CH.sub.3, Cl, 4-Py, H),
(M-12590, CH.sub.3, CH.sub.3, Cl, 4-Py, Cl), (M-12591, CH.sub.3,
CH.sub.3, Cl, 4-Py, F), (M-12592, CH.sub.3, CH.sub.3, Cl, 4-Py,
CF.sub.3), (M-12593, CH.sub.3, CH.sub.3, Cl, 4-Py, Br), (M-12594,
CH.sub.3, CH.sub.3, Cl, 4-Py, CH.sub.3), (M-12595, CH.sub.3,
CH.sub.3, Cl, 2-Th, H), (M-12596, CH.sub.3, CH.sub.3, Cl, 2-Th,
Cl), (M-12597, CH.sub.3, CH.sub.3, Cl, 2-Th, F), (M-12598,
CH.sub.3, CH.sub.3, Cl, 2-Th, CF.sub.3), (M-12599, CH.sub.3,
CH.sub.3, Cl, 2-Th, Br), (M-12600, CH.sub.3, CH.sub.3, Cl, 2-Th,
CH.sub.3), (M-12601, CH.sub.3, CH.sub.3, Cl, 3-Th, H), (M-12602,
CH.sub.3, CH.sub.3, Cl, 3-Th, Cl), (M-12603, CH.sub.3, CH.sub.3,
Cl, 3-Th, F), (M-12604, CH.sub.3, CH.sub.3, Cl, 3-Th, CF.sub.3),
(M-12605, CH.sub.3, CH.sub.3, Cl, 3-Th, Br), (M-12606, CH.sub.3,
CH.sub.3, Cl, 3-Th, CH.sub.3), (M-12607, CH.sub.3, CH.sub.3, Cl,
pyrrazol-2-yl, H), (M-12608, CH.sub.3, CH.sub.3, Cl, pyrrazol-2-yl,
Cl), (M-12609, CH.sub.3, CH.sub.3, Cl, pyrrazol-2-yl, F), (M-12610,
CH.sub.3, CH.sub.3, Cl, pyrrazol-2-yl, CF.sub.3), (M-12611,
CH.sub.3, CH.sub.3, Cl, pyrrazol-2-yl, Br), (M-12612, CH.sub.3,
CH.sub.3, Cl, pyrrazol-2-yl, CH.sub.3), (M-12613, CH.sub.3,
CH.sub.3, Cl, pyrrazol-3-yl, H), (M-12614, CH.sub.3, CH.sub.3, Cl,
pyrrazol-3-yl, Cl), (M-12615, CH.sub.3, CH.sub.3, Cl,
pyrrazol-3-yl, F), (M-12616, CH.sub.3, CH.sub.3, Cl, pyrrazol-3-yl,
CF.sub.3), (M-12617, CH.sub.3, CH.sub.3, Cl, pyrrazol-3-yl, Br),
(M-12618, CH.sub.3, CH.sub.3, Cl, pyrrazol-3-yl, CH.sub.3),
(M-12619, CH.sub.3, CH.sub.3, Cl, pyrimidin-2-yl, H), (M-12620,
CH.sub.3, CH.sub.3, Cl, pyrimidin-2-yl, Cl), (M-12621, CH.sub.3,
CH.sub.3, Cl, pyrimidin-2-yl, F), (M-12622, CH.sub.3, CH.sub.3, Cl,
pyrimidin-2-yl, CF.sub.3), (M-12623, CH.sub.3, CH.sub.3, Cl,
pyrimidin-2-yl, Br), (M-12624, CH.sub.3, CH.sub.3, Cl,
pyrimidin-2-yl, CH.sub.3), (M-12625, CH.sub.3, CH.sub.3, Cl,
pyrimidin-4-yl, H), (M-12626, CH.sub.3, CH.sub.3, Cl,
pyrimidin-4-yl, Cl), (M-12627, CH.sub.3, CH.sub.3, Cl,
pyrimidin-4-yl, F), (M-12628, CH.sub.3, CH.sub.3, Cl,
pyrimidin-4-yl, CF.sub.3), (M-12629, CH.sub.3, CH.sub.3, Cl,
pyrimidin-4-yl, Br), (M-12630, CH.sub.3, CH.sub.3, Cl,
pyrimidin-4-yl, CH.sub.3), (M-12631, CH.sub.3, CH.sub.3, Cl,
pyrimidin-5-yl, H), (M-12632, CH.sub.3, CH.sub.3, Cl,
pyrimidin-5-yl, Cl), (M-12633, CH.sub.3, CH.sub.3, Cl,
pyrimidin-5-yl, F), (M-12634, CH.sub.3, CH.sub.3, Cl,
pyrimidin-5-yl, CF.sub.3), (M-12635, CH.sub.3, CH.sub.3, Cl,
pyrimidin-5-yl, Br), (M-12636, CH.sub.3, CH.sub.3, Cl,
pyrimidin-5-yl, CH.sub.3), (M-12637, CH.sub.3, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, H), (M-12638, CH.sub.3, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2, Cl), (M-12639, CH.sub.3, CH.sub.3,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, F), (M-12640, CH.sub.3, CH.sub.3,
Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-12641, CH.sub.3,
CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, Br), (M-12642,
CH.sub.3, CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-12643, CH.sub.3, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-12644, CH.sub.3,
CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-12645,
CH.sub.3, CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-12646, CH.sub.3, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-12647,
CH.sub.3, CH.sub.3, Cl, HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-12648, CH.sub.3, CH.sub.3, Cl,
HOOCCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-12649,
CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H), (M-12650,
CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-12651,
CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-12652,
CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-12653,
CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-12654,
CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-12655,
CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-12656, CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl),
(M-12657, CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F),
(M-12658, CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, CF.sub.3),
(M-12659, CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br),
(M-12660, CH.sub.3, CH.sub.3, Cl,
(Me).sub.2NCOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3),
(M-12661, CH.sub.3, CH.sub.3, Cl, MeOCH.sub.2, H), (M-12662,
CH.sub.3, CH.sub.3, Cl, MeOCH.sub.2, Cl), (M-12663, CH.sub.3,
CH.sub.3, Cl, MeOCH.sub.2, F), (M-12664, CH.sub.3, CH.sub.3, Cl,
MeOCH.sub.2, CF.sub.3), (M-12665, CH.sub.3, CH.sub.3, Cl,
MeOCH.sub.2, Br), (M-12666, CH.sub.3, CH.sub.3, Cl, MeOCH.sub.2,
CH.sub.3), (M-12667, CH.sub.3, CH.sub.3, Cl, EtOCH.sub.2, H),
(M-12668, CH.sub.3, CH.sub.3, Cl, EtOCH.sub.2, Cl), (M-12669,
CH.sub.3, CH.sub.3, Cl, EtOCH.sub.2, F), (M-12670, CH.sub.3,
CH.sub.3, Cl, EtOCH.sub.2, CF.sub.3), (M-12671, CH.sub.3, CH.sub.3,
Cl, EtOCH.sub.2, Br), (M-12672, CH.sub.3, CH.sub.3, Cl,
EtOCH.sub.2, CH.sub.3), (M-12673, CH.sub.3, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, H), (M-12674, CH.sub.3, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, Cl), (M-12675, CH.sub.3, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, F), (M-12676, CH.sub.3, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, CF.sub.3), (M-12677, CH.sub.3, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, Br), (M-12678, CH.sub.3, CH.sub.3, Cl,
EtOCH.sub.2CH.sub.2, CH.sub.3), (M-12679, CH.sub.3, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H), (M-12680, CH.sub.3,
CH.sub.3, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-12681,
CH.sub.3, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F),
(M-12682, CH.sub.3, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CF.sub.3), (M-12683,
CH.sub.3, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br),
(M-12684, CH.sub.3, CH.sub.3, Cl,
MeOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3), (M-12685,
CH.sub.3, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2, H), (M-12686,
CH.sub.3, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2, Cl), (M-12687,
CH.sub.3, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2, F), (M-12688,
CH.sub.3, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2, CF.sub.3), (M-12689,
CH.sub.3, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2, Br), (M-12690,
CH.sub.3, CH.sub.3, Cl, MeOCH.sub.2CH.sub.2, CH.sub.3), (M-12691,
CH.sub.3, CH.sub.3, Cl, HOCH.sub.2, H), (M-12692, CH.sub.3,
CH.sub.3, Cl, HOCH.sub.2, Cl), (M-12693, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2, F), (M-12694, CH.sub.3, CH.sub.3, Cl, HOCH.sub.2,
CF.sub.3), (M-12695, CH.sub.3, CH.sub.3, Cl, HOCH.sub.2, Br),
(M-12696, CH.sub.3, CH.sub.3, Cl, HOCH.sub.2, CH.sub.3), (M-12697,
CH.sub.3, CH.sub.3, Cl, HOCH.sub.2CH.sub.2, H), (M-12698, CH.sub.3,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2, Cl), (M-12699, CH.sub.3,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2, F), (M-12700, CH.sub.3, CH.sub.3,
Cl, HOCH.sub.2CH.sub.2, CF.sub.3), (M-12701, CH.sub.3, CH.sub.3,
Cl, HOCH.sub.2CH.sub.2, Br), (M-12702, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2, CH.sub.3), (M-12703, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, H), (M-12704, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, Cl), (M-12705, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, F), (M-12706, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2, CF.sub.3), (M-12707, CH.sub.3,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2, Br), (M-12708, CH.sub.3,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2, CH.sub.3), (M-12709,
CH.sub.3, CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, H),
(M-12710, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Cl), (M-12711, CH.sub.3,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-12712,
CH.sub.3, CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2,
CF.sub.3), (M-12713, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-12714, CH.sub.3,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2, CH.sub.3),
(M-12715, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2H), (M-12716, CH.sub.3,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2Cl),
(M-12717, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, F), (M-12718, CH.sub.3,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CF.sub.3),
(M-12719, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2, Br), (M-12720,
CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.2CH.sub.3), (M-12721,
CH.sub.3, CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, H),
(M-12722, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Cl), (M-12723, CH.sub.3,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, F), (M-12724,
CH.sub.3, CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2,
CF.sub.3), (M-12725, CH.sub.3, CH.sub.3, Cl,
HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, Br), (M-12726, CH.sub.3,
CH.sub.3, Cl, HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2, CH.sub.3),
(M-12727, CH.sub.3, CH.sub.3, Cl, (Me).sub.2N, H), (M-12728,
CH.sub.3, CH.sub.3, Cl, (Me).sub.2N, Cl), (M-12729, CH.sub.3,
CH.sub.3, Cl, (Me).sub.2N, F), (M-12730, CH.sub.3, CH.sub.3, Cl,
(Me).sub.2N, CF.sub.3), (M-12731, CH.sub.3, CH.sub.3, Cl,
(Me).sub.2N, Br), (M-12732, CH.sub.3, CH.sub.3, Cl, (Me).sub.2N,
CH.sub.3), (M-12733, CH.sub.3, CH.sub.3, Cl, piperidin-4-yl-methyl,
H), (M-12734, CH.sub.3, CH.sub.3, Cl, piperidin-4-yl-methyl, Cl),
(M-12735, CH.sub.3, CH.sub.3, Cl, piperidin-4-yl-methyl, F),
(M-12736, CH.sub.3, CH.sub.3, Cl, piperidin-4-yl-methyl, CF.sub.3),
(M-12737, CH.sub.3, CH.sub.3, Cl, piperidin-4-yl-methyl, Br),
(M-12738, CH.sub.3, CH.sub.3, Cl, piperidin-4-yl-methyl, CH.sub.3),
(M-12739, CH.sub.3, CH.sub.3, Cl, cyclohexylmethyl, H), (M-12740,
CH.sub.3, CH.sub.3, Cl, cyclohexylmethyl, Cl), (M-12741, CH.sub.3,
CH.sub.3, Cl, cyclohexylmethyl, F), (M-12742, CH.sub.3, CH.sub.3,
Cl, cyclohexylmethyl, CF.sub.3), (M-12743, CH.sub.3, CH.sub.3, Cl,
cyclohexylmethyl, Br), (M-12744, CH.sub.3, CH.sub.3, Cl,
cyclohexylmethyl, CH.sub.3), (M-12745, H, H, H, CH.sub.3, H),
(M-12746, H, H, H, CH.sub.3, Cl), (M-12747, H, H, H, CH.sub.3, F),
(M-12748, H, H, H, CH.sub.3, CF.sub.3), (M-12749, H, H, H,
CH.sub.3, Br), (M-12750, H, H, H, CF.sub.3, CH.sub.3), (M-12751, H,
H, F, CF.sub.3, H), (M-12752, H, H, F, CF.sub.3, Cl), (M-12753, H,
H, F, CF.sub.3, F), (M-12754, H, H, F, CF.sub.3, CF.sub.3),
(M-12755, H, H, F, CF.sub.3, Br), (M-12756, H, H, F, CF.sub.3,
CH.sub.3), (M-12757, H, H, Cl, CF.sub.3, H), (M-12758, H, H, Cl,
CF.sub.3
, Cl), (M-12759, H, H, Cl, CF.sub.3, F), (M-12760, H, H, Cl,
CF.sub.3, CF.sub.3), (M-12761, H, H, Cl, CF.sub.3, Br), (M-12762,
H, H, Cl, CF.sub.3, CH.sub.3), (M-12763, H, F, H, CF.sub.3, H),
(M-12764, H, F, H, CF.sub.3, Cl), (M-12765, H, F, H, CF.sub.3, F),
(M-12766, H, F, H, CF.sub.3, CF.sub.3), (M-12767, H, F, H,
CF.sub.3, Br), (M-12768, H, F, H, CF.sub.3, CH.sub.3), (M-12769, H,
F, F, CF.sub.3, H), (M-12770, H, F, F, CF.sub.3, Cl), (M-12771, H,
F, F, CF.sub.3, F), (M-12772, H, F, F, CF.sub.3, CF.sub.3),
(M-12773, H, F, F, CF.sub.3, Br), (M-12774, H, F, F, CF.sub.3,
CH.sub.3), (M-12775, H, F, Cl, CF.sub.3, H), (M-12776, H, F, Cl,
CF.sub.3, Cl), (M-12777, H, F, Cl, CF.sub.3, F), (M-12778, H, F,
Cl, CF.sub.3, CF.sub.3), (M-12779, H, F, Cl, CF.sub.3, Br),
(M-12780, H, F, Cl, CF.sub.3, CH.sub.3), (M-12781, H, CH.sub.3, H,
CF.sub.3, H), (M-12782, H, CH.sub.3, H, CF.sub.3, Cl), (M-12783, H,
CH.sub.3, H, CF.sub.3, F), (M-12784, H, CH.sub.3, H, CF.sub.3,
CF.sub.3), (M-12785, H, CH.sub.3, H, CF.sub.3, Br), (M-12786, H,
CH.sub.3, H, CF.sub.3, CH.sub.3), (M-12787, H, CH.sub.3, F,
CF.sub.3, H), (M-12788, H, CH.sub.3, F, CF.sub.3, Cl), (M-12789, H,
CH.sub.3, F, CF.sub.3, F), (M-12790, H, CH.sub.3, F, CF.sub.3,
CF.sub.3), (M-12791, H, CH.sub.3, F, CF.sub.3, Br), (M-12792, H,
CH.sub.3, F, CF.sub.3, CH.sub.3), (M-12793, H, CH.sub.3, Cl,
CF.sub.3, H), (M-12794, H, CH.sub.3, Cl, CF.sub.3, Cl), (M-12795,
H, CH.sub.3, Cl, CF.sub.3, F), (M-12796, H, CH.sub.3, Cl, CF.sub.3,
CF.sub.3), (M-12797, H, CH.sub.3, Cl, CF.sub.3, Br), (M-12798, H,
CH.sub.3, Cl, CF.sub.3, CH.sub.3), (M-12799, F, H, H, CF.sub.3,
i-Pr), (M-12800, F, H, H, CF.sub.3, Cl), (M-12801, F, H, H,
CF.sub.3, F), (M-12802, F, H, H, CF.sub.3, CF.sub.3), (M-12803, F,
H, H, CF.sub.3, Br), (M-12804, F, H, H, CF.sub.3, CH.sub.3),
(M-12805, F, H, F, CF.sub.3, H), (M-12806, F, H, F, CF.sub.3, Cl),
(M-12807, F, H, F, CF.sub.3, F), (M-12808, F, H, F, CF.sub.3,
CF.sub.3), (M-12809, F, H, F, CF.sub.3, Br), (M-12810, F, H, F,
CF.sub.3, CH.sub.3), (M-12811, F, H, Cl, CF.sub.3, H), (M-12812, F,
H, Cl, CF.sub.3, Cl), (M-12813, F, H, Cl, CF.sub.3, F), (M-12814,
K, H, Cl, CF.sub.3, CF.sub.3), (M-12815, F, H, Cl, CF.sub.3, Br),
(M-12816, F, H, Cl, CF.sub.3, CH.sub.3), (M-12817, F, F, H,
CF.sub.3, H), (M-12818, F, F, H, CF.sub.3, Cl), (M-12819, F, F, H,
CF.sub.3, F), (M-12820, F, F, H, CF.sub.3, CF.sub.3), (M-12821, F,
F, H, CF.sub.3, Br), (M-12822, F, F, H, CF.sub.3, CH.sub.3),
(M-12823, F, F, F, CF.sub.3, H), (M-12824, F, F, F, CF.sub.3, Cl),
(M-12825, F, F, F, CF.sub.3, F), (M-12826, F, F, F, CF.sub.3,
CF.sub.3), (M-12827, F, F, F, CF.sub.3, Br), (M-12828, V, F, F,
CF.sub.3, CH.sub.3), (M-12829, F, F, Cl, CF.sub.3, H), (M-12830, F,
F, Cl, CF.sub.3, Cl), (M-12831, F, F, Cl, CF.sub.3, F), (M-12832,
F, F, Cl, CF.sub.3, CF.sub.3), (M-12833, F, F, Cl, CF.sub.3, Br),
(M-12834, F, F, Cl, CF.sub.3, CH.sub.3), (M-12835, F, CH.sub.3, H,
CF.sub.3, H), (M-12836, F, CH.sub.3, H, CF.sub.3, Cl), (M-12837, F,
CH.sub.3, H, CF.sub.3, F), (M-12838, F, CH.sub.3, H, CF.sub.3,
CF.sub.3), (M-12839, F, CH.sub.3, H, CF.sub.3, Br), (M-12840, F,
CH.sub.3, H, CF.sub.3, CH.sub.3), (M-12841, F, CH.sub.3, F,
CF.sub.3, H), (M-12842, F, CH.sub.3, F, CF.sub.3, Cl), (M-12843, F,
CH.sub.3, F, CF.sub.3, F), (M-12844, F, CH.sub.3, F, CF.sub.3,
CF.sub.3), (M-12845, F, CH.sub.3, F, CF.sub.3, Br), (M-12846, F,
CH.sub.3, F, CF.sub.3, CH.sub.3), (M-12847, F, CH.sub.3, Cl,
CF.sub.3, H), (M-12848, F, CH.sub.3, Cl, CF.sub.3, Cl), (M-12849,
F, CH.sub.3, Cl, CF.sub.3, P), (M-12850, F, CH.sub.3, Cl, CF.sub.3,
CF.sub.3), (M-12851, F, CH.sub.3, Cl, CF.sub.3, Br), (M-12852, F,
CH.sub.3, Cl, CF.sub.3, CH.sub.3), (M-12853, Cl, H, H, CF.sub.3,
i-Pr), (M-12854, Cl, H, H, CF.sub.3, Cl), (M-12855, Cl, H, H,
CF.sub.3, F), (M-12856, Cl, H, H, CF.sub.3, CF.sub.3), (M-12867,
Cl, H, H, CF.sub.3, Br), (M-12858, Cl, H, H, CF.sub.3, CH.sub.3),
(M-12859, Cl, H, F, CF.sub.3, i-Pr), (M-12860, Cl, H, F, CF.sub.3,
Cl), (M-12861, Cl, H, F, CF.sub.3, F), (M-12862, Cl, H, F,
CF.sub.3, CF.sub.3), (M-12863, Cl, H, F, CF.sub.3, Br), (M-12864,
Cl, H, F, CF.sub.3, CH.sub.3), (M-12865, Cl, H, Cl, CF.sub.3, H),
(M-12866, Cl, H, Cl, CF.sub.3, Cl), (M-12867, Cl, Ft, Cl, CF.sub.3,
F), (M-12868, Cl, H, Cl, CF.sub.3, CF.sub.3), (M-12869, Cl, H, Cl,
CF.sub.3, Br), (M-12870, Cl, H, Cl, CF.sub.3, CH.sub.3), (M-12871,
Cl, F, H, CF.sub.3, i-Pr), (M-12872, Cl, F, H, CF.sub.3, Cl),
(M-12873, Cl, F, H, CF.sub.3, F), (M-12874, Cl, F, H, CF.sub.3,
CF.sub.3), (M-12875, Cl, F, H, CF.sub.3, Br), (M-12876, Cl, F, H,
CF.sub.3, CH.sub.3), (M-12877, Cl, F, F, CF.sub.3, H), (M-12878,
Cl, F, F, CF.sub.3, Cl), (M-12879, Cl, F, F, CF.sub.3, F),
(M-12880, Cl, F, F, CF.sub.3, CF.sub.3), (M-12881, Cl, F, F,
CF.sub.3, Br), (M-12882, Cl, F, F, CF.sub.3, CH.sub.3), (M-12883,
Cl, F, Cl, CF.sub.3, H), (M-12884, Cl, F, Cl, CF.sub.3, Cl),
(M-12885, Cl, F, Cl, CF.sub.3, F), (M-12886, Cl, F, Cl, CF.sub.3,
CF.sub.3), (M-12887, Cl, F, Cl, CF.sub.3, Br), (M-12888, Cl, F, Cl,
CF.sub.3, CH.sub.3), (M-12889, Cl, CH.sub.3, H, CF.sub.3, i-Pr),
(M-12890, Cl, CH.sub.3, H, CF.sub.3) Cl), M-12891, Cl, CH.sub.3, H,
CF.sub.3, F), (M-12892, Cl, CH.sub.3, H, CF.sub.3, CF.sub.3),
(M-12893, Cl, CH.sub.3, H, CF.sub.3, Br), (M-12894, Cl, CH.sub.3,
H, CF.sub.3, CH.sub.3), (M-12895, Cl, CH.sub.3, F, CF.sub.3, i-Pr),
(M-12896, Cl, CH.sub.3, F, CF.sub.3, Cl), (M-12897, Cl, CH.sub.3,
F, CF.sub.3, F), (M-12898, Cl, CH.sub.3, F, CF.sub.3, CF.sub.3),
(M-12899, Cl, CH.sub.3, F, CF.sub.3, Br), (M-12900, Cl, CH.sub.3,
F, CF.sub.3, CH.sub.3), (M-12901, Cl, CH.sub.3, Cl, CF.sub.3, H),
(M-12902, Cl, CH.sub.3, Cl, CF.sub.3, Cl), (M-12903, Cl, CH.sub.3,
Cl, CF.sub.3, F), (M-12904, Cl, CH.sub.3, Cl, CF.sub.3, CF.sub.3),
(M-12905, Cl, CH.sub.3, Cl, CF.sub.3, Br), (M-12906, Cl, CH.sub.3,
Cl, CF.sub.3, CH.sub.3), (M-12907, CH.sub.3, H, H, CF.sub.3, i-Pr),
(M-12908, CH.sub.3, H, H, CF.sub.3, Cl), (M-12909, CH.sub.3, H, H,
CF.sub.3, F), (M-12910, CH.sub.3, H, H, CF.sub.3, CF.sub.3),
(M-12911, CH.sub.3, H, H, CF.sub.3, Br), (M-12912, CH.sub.3, H, H,
CF.sub.3, CH.sub.3), (M-12913, CH.sub.3, H, F, CF.sub.3, H),
(M-12914, CH.sub.3, H, F, CF.sub.3, Cl), (M-12915, CH.sub.3, H, F,
CF.sub.3, F), (M-12916, CH.sub.3, H, F, CF.sub.3, CF.sub.3),
(M-12917, CH.sub.3, H, F, CF.sub.3, Br), (M-12918, CH.sub.3, H, F,
CF.sub.3, CH.sub.3), (M-12919, CH.sub.3, H, Cl, CF.sub.3, H),
(M-12920, CH.sub.3, H, Cl, CF.sub.3, Cl), (M-12921, CH.sub.3, H,
Cl, CF.sub.3, F), (M-12922, CH.sub.3, H, Cl, CF.sub.3, CF.sub.3),
(M-12923, CH.sub.3, H, Cl, CF.sub.3, Br), (M-12924, CH.sub.3, H,
Cl, CF.sub.3, CH.sub.3), (M-12925, CH.sub.3, F, H, CF.sub.3, H),
(M-12926, CH.sub.3, F, H, CF.sub.3, Cl), (M-12927, CH.sub.3, F, H,
CF.sub.3, F), (M-12928, CH.sub.3, F, H, CF.sub.3, CF.sub.3),
(M-12929, CH.sub.3, F, H, CF.sub.3, Br), (M-12930, CH.sub.3, F, H,
CF.sub.3, CH.sub.3), (M-12931, CH.sub.3, F, F, CF.sub.3, H),
(M-12932, CH.sub.3, F, F, CF.sub.3, Cl), (M-12933, CH.sub.3, F, F,
CF.sub.3, F), (M-12934, CH.sub.3, F, F, CF.sub.3, CF.sub.3),
(M-12935, CH.sub.3, F, F, CF.sub.3, Br), (M-12936, CH.sub.3, F, F,
CF.sub.3, CH.sub.3), (M-12937, CH.sub.3, F, Cl, CF.sub.3, H),
(M-12938, CH.sub.3, F, Cl, CF.sub.3, Cl), (M-12939, CH.sub.3, F,
Cl, CF.sub.3, F), (M-12940, CH.sub.3, F, Cl, CF.sub.3, CF.sub.3),
(M-12941, CH.sub.3, F, Cl, CF.sub.3, Br), (M-12942, CH.sub.3, F,
Cl, CF.sub.3, CH.sub.3), (M-12943, CH.sub.3, CH.sub.3, H, CF.sub.3,
H), (M-12944, CH.sub.3, CH.sub.3, H, CF.sub.3, Cl), (M-12945,
CH.sub.3, CH.sub.3, H, CF.sub.3, F), (M-12946, CH.sub.3, CH.sub.3,
H, CF.sub.3, CF.sub.3), (M-12947, CH.sub.3, CH.sub.3, H, CF.sub.3,
Br), (M-12948, CH.sub.3, CH.sub.3, H, CF.sub.3, CH.sub.3),
(M-12949, CH.sub.3, CH.sub.3, F, CF.sub.3, H), (M-12950, CH.sub.3,
CH.sub.3, F, CF.sub.3, Cl), (M-12951, CH.sub.3, CH.sub.3, F,
CF.sub.3, F), (M-12952, CH.sub.3, CH.sub.3, F, CF.sub.3, CF.sub.3),
(M-12953, CH.sub.3, CH.sub.3, F, CF.sub.3, Br), (M-12954, CH.sub.3,
CH.sub.3, F, CF.sub.3, CH.sub.3), (M-12955, CH.sub.3, CH.sub.3, Cl,
CF.sub.3, H), (M-12956, CH.sub.3, CH.sub.3, Cl, CF.sub.3, Cl),
(M-12957, CH.sub.3, CH.sub.3, Cl, CF.sub.3, F), (M-12958, CH.sub.3,
CH.sub.3, Cl, CF.sub.3, CF.sub.3), (M-12959, CH.sub.3, CH.sub.3,
Cl, CF.sub.3, Br), (M-12960, CH.sub.3, CH.sub.3, Cl, CF.sub.3,
CH.sub.3),
TEST EXAMPLES
Test Example 1
Isolation and Purification of Thrombopoietin (TPO)
[0160] Human TPO (hTPO) and murine TPO (in TPO) were purchased from
R&D Systems.
Test Example 2
The Increasing Effect In Vitro of the Megakaryocyte Colonies with
the Compound (B-1)
[0161] We examined the ability of the compound in promoting
differentiation of human hematopoietic progenitor cells into mature
megakaryocytes. Human bone marrow cells (2.2.times.10.sup.5 cells)
were plated in 3-cm dishes and cultured in methylcellulose in
Iscove's Modified Dulbccco's medium in the presence of 1% of the
compound dissolved in 10% ethanol. After incubation at 37.degree.
C. for 7 days in the 5% CO.sub.2 incubator, the megakaryocyte
colonies were counted. The results are shown in FIG. 1.
Test Example 3
The Thrombopoietic Activity of the Compound (B-1)
[0162] The TPO dependent BaF/hTPOR cell line which was established
by introducing human TPO receptor (hTPOR) into BaF-B03 cells
according to Collins et al (J. Cell. Physiol., 137:293-298 (1988))
was used to test the thrombopoietic activity of the present
compound. The DNA sequences and encoded peptide sequences for human
hTPOR have been described by Vigon et al (Proc. Natl. Acad. Sci.
USA, 89:5640-5644 (1992)). TPO dose not have any ability to support
proliferation of interleukin-3 dependent parental cell line
BaF-B03. BAF/hTPOR cells were maintained in RPMI medium and WEHI-3B
conditioned medium as a source of murine interleukin-3 (IL-3).
These cells were washed and resuspended in RPMI medium without a
source of murine IL-3 and seeded into each well of 96-well
microtiter plates at a density of 5.times.10.sup.4 cells per well
in the absence or presence of various concentration of hTPO or the
present compound. After incubation at 37.degree. C. for 20 hours in
the 5% CO.sub.2 incubator, 10% WST-1 reagent (Takara Biomedicals,
Japan) was added to each wells and the cells were further incubated
for 4 hours. The absorbance at 450 nm was measured and the results
are shown in FIG. 2. Effect of the present compound on the growth
of BAF/mTPOR cell line which was established by introducing murine
TPO receptor (mTPOR) into BAF-B03 cells is shown in FIG. 3. Table 8
exemplifies the ED.sub.50 for tested compounds of the present
invention, wherein the ED.sub.50 is the half concentration of the
concentration showing the maximum thrombopoietic activity.
TABLE-US-00033 TABLE 33 Compound ED.sub.50 ED.sub.50 Compound
ED.sub.50 ED.sub.50 No. (.mu.M) No. (.mu.M) No. (.mu.M) No. (.mu.M)
A-1 0.117 A-54 0.065 B-6 0.084 G-5 0.260 A-2 0.066 A-55 0.037 B-7
0.059 G-6 0.370 A-3 0.218 A-56 0.066 B-8 0.378 G-7 0.400 A-4 0.124
A-57 0.019 B-9 0.082 G-8 0.360 A-5 0.984 A-58 0.497 B-11 0.236 H-7
0.038 A-6 0.248 A-59 0.164 B-12 0.207 H-8 0.250 A-8 0.529 A-60
0.023 B-13 0.213 J-11 0.311 A-9 0.504 A-61 0.207 B-14 0.305 J-12
0.107 A-10 0.365 A-62 0.101 B-15 0.197 J-13 0.116 A-11 0.0335 A-63
0.025 B-16 0.182 J-14 0.036 A-14 0.017 A-64 0.204 B-17 0.244 J-15
0.011 A-17 0.864 A-65 0.028 B-18 0.15 K-1 0.189 A-18 0.132 A-66
0.211 B-19 0.15 K-2 0.975 A-19 0.170 A-68 0.222 B-20 0.425 K-3
0.693 A-20 0.610 A-69 0.071 B-25 0.367 K-5 0.403 A-23 0.337 A-70
0.089 B-26 0.346 K-6 0.077 A-24 0.288 A-72 0.119 B-27 0.707 K-10
0.475 A-25 0.150 A-73 0.075 B-28 0.565 K-11 0.373 A-26 0.098 A-74
0.472 B-29 0.181 K-12 0.208 A-27 0.193 A-75 0.073 B-30 0.177 K-13
0.260 A-28 0.099 A-76 0.205 B-31 0.178 K-15 0.465 A-29 0.289 A-77
0.110 B-32 0.123 L-1 0.208 A-30 0.274 A-78 0.408 B-33 0.372 L-2
0.143 A-31 0.056 A-79 0.410 B-34 0.398 L-3 0.321 A-32 0.040 A-80
0.066 B-35 0.186 L-4 0.256 A-35 0.096 A-81 0.071 B-36 0.163 A-36
0.095 A-82 0.199 B-37 0.139 A-37 0.096 A-83 0.077 B-38 0.239 A-38
0.245 A-84 0.023 B-39 0.729 A-39 0.044 A-85 0.026 B-40 0.201 A-40
0.047 A-86 0.243 B-41 0.19 A-41 0.039 A-87 0.710 B-42 0.236 A-42
0.050 A-88 0.028 B-43 0.303 A-43 0.071 A-89 0.072 B-46 0.213 A-44
0.227 A-90 0.805 C-4 0.922 A-45 0.203 A-91 0.076 D-1 0.276 A-46
0.263 A-92 0.178 F-1 0.174 A-47 0.512 A-93 0.008 F-2 0.144 A-48
0.473 B-1 0.081 F-3 0.198 A-49 0.116 B-2 0.257 G-1 0.261 A-50 0.113
B-3 0.156 G-2 0.299 A-51 0.568 B-4 0.089 G-3 0.430 A-52 0.425 B-5
0.123 G-4 0.240
[0163] As shown in FIG. 1, addition of the compounds of the present
invention induced forming megakaryocyte colonies and the number of
colonies increased depending on the concentration of the compounds.
This result revealed that the compounds of the present invention
induced the differentiation of human bone marrow cells and produced
megakaryocytes having ability of producing platelet.
[0164] The compound supported the proliferation of TPO-dependent
BaF/hTPOR in a dose-dependent manner as shown in FIG. 2. BaF/mTPOR
expressing murine TPOR was not induced the proliferation by
compounds as shown in FIG. 3. These results suggest that the
compound of the present invention exert the thrombopoietic activity
by interacting with hTPOR because it is active only in cells
expressing hTPOR.
Formulation Example
Formulation Example 1
[0165] Granules are prepared using the following ingredients.
TABLE-US-00034 Ingredients The compound represented by the Formula
(I) 10 mg Lactose 700 mg Corn starch 274 mg HPC-L 16 mg 1000 mg
[0166] The compound represented by the formula (I) and lactose are
made pass through a 60 mesh sieve. Corn starch is made pass through
a 120 mesh sieve. They are mixed by a twin shell blender. An
aqueous solution of HPC-L (low mucosity hydroxypropylcellulose) is
added to the mixture and the resulting mixture is kneaded,
granulated (by the extrusion with pore size 0.5 to 1 mm mesh), and
dried. The dried granules thus obtained are sieved by a swing sieve
(12/60 mesh) to yield the granules.
Formulation 2
[0167] Powders for filling capsules are prepared using the
following ingredients.
TABLE-US-00035 Ingredients The compound represented by the formula
(I) 10 mg Lactose 79 mg Corn starch 10 mg Magnesium stearate 1 mg
100 mg
[0168] The compound represented by the formula (I) and lactose are
made pass through a 60 mesh sieve. Corn starch is made pass through
a 120 mesh sieve. These ingredients and magnesium stearate are
mixed by a twin shell blender. 100 mg of the 10-fold trituration is
filled into a No. 5 hard gelatin capsule.
Formulation 3
[0169] Granules for filling capsules are prepared using the
following ingredients
TABLE-US-00036 Ingredients The compound represented by the formula
(I) 15 mg Lactose 90 mg Corn starch 42 mg HPC-L 3 mg 150 mg
[0170] The compound represented by the formula (I) and lactose are
made pass through a 60 mesh sieve. Corn starch is made pass through
a 120 mesh sieve. After mixing them, an aqueous solution of HPC-L
is added to the mixture and the resulting mixture is kneaded,
granulated, and dried. After the dried granules are lubricated, 150
mg of that are filled into a No. 4 hard gelatin capsule.
Formulation 4
[0171] Tablets are prepared using the following ingredients.
TABLE-US-00037 Ingredients The compound represented by the formula
(I) 10 mg Lactose 90 mg Microcrystal cellulose 30 mg CMC-Na 15 mg
Magnesium stearate 5 mg 150 mg
[0172] The compound represented by the formula (I), lactose,
microcrystal cellulose, and CMC-Na (carboxymethylcellulose sodium
salt) are made pass through a 60 mesh sieve and then mixed. The
resulting mixture is mixed with magnesium stearate to obtain the
mixed powder for the tablet formulation. The mixed powder is
compressed to yield tablets of 150 mg.
Formulation 5
[0173] Intravenous formulations are prepared using the following
ingredients.
TABLE-US-00038 Ingredients The compound represented by the formula
(I) 100 mg Saturated fattyacid glyceride 1000 ml
[0174] Usually a solution of ingredients above described is
administered intravenously to a patient by the speed of 1
ml/min.
INDUSTRIAL APPLICABILITY
[0175] The compounds of the present invention have thrombopoietin
receptor agonism and are useful as the treating or preventing agent
for hemopathy accompanied with unusual count of platelet, for
example, thrombocytopenia and the like
* * * * *