U.S. patent application number 12/566167 was filed with the patent office on 2010-01-28 for genetically altered anti-body producing cell lines with improved antibody characteristics. This patent application is currently assigned to MORPHOTEK, INC.. Invention is credited to Luigi Grasso, Nicholas C. Nicolaides, Philip M. Sass.
Application Number | 20100021996 12/566167 |
Document ID | / |
Family ID | 34221808 |
Filed Date | 2010-01-28 |
United States Patent Application | 20100021996 |
Kind Code | A1 |
Grasso; Luigi ; et al. | January 28, 2010 |
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. Cells may be selected for expression of activation-induced cytidine deaminase (AID), stimulated to produce AID, or manipulated to express AID for further enhancement of hypermutability. These methods are useful for generating genetic diversity within immunoglobulin genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production.
Inventors: | Grasso; Luigi; (Bryn Mawr, PA) ; Nicolaides; Nicholas C.; (Garnett Valley, PA) ; Sass; Philip M.; (Audubon, PA) |
Correspondence Address: |
WOODCOCK WASHBURN LLP CIRA CENTRE, 12TH FLOOR, 2929 ARCH STREET PHILADELPHIA PA 19104-2891 US |
Assignee: | MORPHOTEK, INC. Exton PA |
Family ID: | 34221808 |
Appl. No.: | 12/566167 |
Filed: | September 24, 2009 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
10933034 | Sep 2, 2004 | 7604994 | ||
12566167 | ||||
60500071 | Sep 3, 2003 | |||
Current U.S. Class: | 435/326 |
Current CPC Class: | C12N 5/12 20130101; C12N 2501/23 20130101; C07H 21/04 20130101; C12N 2501/052 20130101; C12N 2501/52 20130101; C07K 16/4291 20130101; C12N 2501/15 20130101; C12N 2510/02 20130101; C12N 15/1024 20130101; C07K 16/00 20130101 |
Class at Publication: | 435/326 |
International Class: | C12N 5/16 20060101 C12N005/16 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 55 <210> SEQ ID NO 1 <211> LENGTH: 3063
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 1 ggcacgagtg gctgcttgcg gctagtggat ggtaattgcc
tgcctcgcgc tagcagcaag 60 ctgctctgtt aaaagcgaaa atgaaacaat
tgcctgcggc aacagttcga ctcctttcaa 120 gttctcagat catcacttcg
gtggtcagtg ttgtaaaaga gcttattgaa aactccttgg 180 atgctggtgc
cacaagcgta gatgttaaac tggagaacta tggatttgat aaaattgagg 240
tgcgagataa cggggagggt atcaaggctg ttgatgcacc tgtaatggca atgaagtact
300 acacctcaaa aataaatagt catgaagatc ttgaaaattt gacaacttac
ggttttcgtg 360 gagaagcctt ggggtcaatt tgttgtatag ctgaggtttt
aattacaaca agaacggctg 420 ctgataattt tagcacccag tatgttttag
atggcagtgg ccacatactt tctcagaaac 480 cttcacatct tggtcaaggt
acaactgtaa ctgctttaag attatttaag aatctacctg 540 taagaaagca
gttttactca actgcaaaaa aatgtaaaga tgaaataaaa aagatccaag 600
atctcctcat gagctttggt atccttaaac ctgacttaag gattgtcttt gtacataaca
660 aggcagttat ttggcagaaa agcagagtat cagatcacaa gatggctctc
atgtcagttc 720 tggggactgc tgttatgaac aatatggaat cctttcagta
ccactctgaa gaatctcaga 780 tttatctcag tggatttctt ccaaagtgtg
atgcagacca ctctttcact agtctttcaa 840 caccagaaag aagtttcatc
ttcataaaca gtcgaccagt acatcaaaaa gatatcttaa 900 agttaatccg
acatcattac aatctgaaat gcctaaagga atctactcgt ttgtatcctg 960
ttttctttct gaaaatcgat gttcctacag ctgatgttga tgtaaattta acaccagata
1020 aaagccaagt attattacaa aataaggaat ctgttttaat tgctcttgaa
aatctgatga 1080 cgacttgtta tggaccatta cctagtacaa attcttatga
aaataataaa acagatgttt 1140 ccgcagctga catcgttctt agtaaaacag
cagaaacaga tgtgcttttt aataaagtgg 1200 aatcatctgg aaagaattat
tcaaatgttg atacttcagt cattccattc caaaatgata 1260 tgcataatga
tgaatctgga aaaaacactg atgattgttt aaatcaccag ataagtattg 1320
gtgactttgg ttatggtcat tgtagtagtg aaatttctaa cattgataaa aacactaaga
1380 atgcatttca ggacatttca atgagtaatg tatcatggga gaactctcag
acggaatata 1440 gtaaaacttg ttttataagt tccgttaagc acacccagtc
agaaaatggc aataaagacc 1500 atatagatga gagtggggaa aatgaggaag
aagcaggtct tgaaaactct tcggaaattt 1560 ctgcagatga gtggagcagg
ggaaatatac ttaaaaattc agtgggagag aatattgaac 1620 ctgtgaaaat
tttagtgcct gaaaaaagtt taccatgtaa agtaagtaat aataattatc 1680
caatccctga acaaatgaat cttaatgaag attcatgtaa caaaaaatca aatgtaatag
1740 ataataaatc tggaaaagtt acagcttatg atttacttag caatcgagta
atcaagaaac 1800 ccatgtcagc aagtgctctt tttgttcaag atcatcgtcc
tcagtttctc atagaaaatc 1860 ctaagactag tttagaggat gcaacactac
aaattgaaga actgtggaag acattgagtg 1920 aagaggaaaa actgaaatat
gaagagaagg ctactaaaga cttggaacga tacaatagtc 1980 aaatgaagag
agccattgaa caggagtcac aaatgtcact aaaagatggc agaaaaaaga 2040
taaaacccac cagcgcatgg aatttggccc agaagcacaa gttaaaaacc tcattatcta
2100 atcaaccaaa acttgatgaa ctccttcagt cccaaattga aaaaagaagg
agtcaaaata 2160 ttaaaatggt acagatcccc ttttctatga aaaacttaaa
aataaatttt aagaaacaaa 2220 acaaagttga cttagaagag aaggatgaac
cttgcttgat ccacaatctc aggtttcctg 2280 atgcatggct aatgacatcc
aaaacagagg taatgttatt aaatccatat agagtagaag 2340 aagccctgct
atttaaaaga cttcttgaga atcataaact tcctgcagag ccactggaaa 2400
agccaattat gttaacagag agtcttttta atggatctca ttatttagac gttttatata
2460 aaatgacagc agatgaccaa agatacagtg gatcaactta cctgtctgat
cctcgtctta 2520 cagcgaatgg tttcaagata aaattgatac caggagtttc
aattactgaa aattacttgg 2580 aaatagaagg aatggctaat tgtctcccat
tctatggagt agcagattta aaagaaattc 2640 ttaatgctat attaaacaga
aatgcaaagg aagtttatga atgtagacct cgcaaagtga 2700 taagttattt
agagggagaa gcagtgcgtc tatccagaca attacccatg tacttatcaa 2760
aagaggacat ccaagacatt atctacagaa tgaagcacca gtttggaaat gaaattaaag
2820 agtgtgttca tggtcgccca ttttttcatc atttaaccta tcttccagaa
actacatgat 2880 taaatatgtt taagaagatt agttaccatt gaaattggtt
ctgtcataaa acagcatgag 2940 tctggtttta aattatcttt gtattatgtg
tcacatggtt attttttaaa tgaggattca 3000 ctgacttgtt tttatattga
aaaaagttcc acgtattgta gaaaacgtaa ataaactaat 3060 aac 3063
<210> SEQ ID NO 2 <211> LENGTH: 932 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 2 Met
Lys Gln Leu Pro Ala Ala Thr Val Arg Leu Leu Ser Ser Ser Gln 1 5 10
15 Ile Ile Thr Ser Val Val Ser Val Val Lys Glu Leu Ile Glu Asn Ser
20 25 30 Leu Asp Ala Gly Ala Thr Ser Val Asp Val Lys Leu Glu Asn
Tyr Gly 35 40 45 Phe Asp Lys Ile Glu Val Arg Asp Asn Gly Glu Gly
Ile Lys Ala Val 50 55 60 Asp Ala Pro Val Met Ala Met Lys Tyr Tyr
Thr Ser Lys Ile Asn Ser 65 70 75 80 His Glu Asp Leu Glu Asn Leu Thr
Thr Tyr Gly Phe Arg Gly Glu Ala 85 90 95 Leu Gly Ser Ile Cys Cys
Ile Ala Glu Val Leu Ile Thr Thr Arg Thr 100 105 110 Ala Ala Asp Asn
Phe Ser Thr Gln Tyr Val Leu Asp Gly Ser Gly His 115 120 125 Ile Leu
Ser Gln Lys Pro Ser His Leu Gly Gln Gly Thr Thr Val Thr 130 135 140
Ala Leu Arg Leu Phe Lys Asn Leu Pro Val Arg Lys Gln Phe Tyr Ser 145
150 155 160 Thr Ala Lys Lys Cys Lys Asp Glu Ile Lys Lys Ile Gln Asp
Leu Leu 165 170 175 Met Ser Phe Gly Ile Leu Lys Pro Asp Leu Arg Ile
Val Phe Val His 180 185 190 Asn Lys Ala Val Ile Trp Gln Lys Ser Arg
Val Ser Asp His Lys Met 195 200 205 Ala Leu Met Ser Val Leu Gly Thr
Ala Val Met Asn Asn Met Glu Ser 210 215 220 Phe Gln Tyr His Ser Glu
Glu Ser Gln Ile Tyr Leu Ser Gly Phe Leu 225 230 235 240 Pro Lys Cys
Asp Ala Asp His Ser Phe Thr Ser Leu Ser Thr Pro Glu 245 250 255 Arg
Ser Phe Ile Phe Ile Asn Ser Arg Pro Val His Gln Lys Asp Ile 260 265
270 Leu Lys Leu Ile Arg His His Tyr Asn Leu Lys Cys Leu Lys Glu Ser
275 280 285 Thr Arg Leu Tyr Pro Val Phe Phe Leu Lys Ile Asp Val Pro
Thr Ala 290 295 300 Asp Val Asp Val Asn Leu Thr Pro Asp Lys Ser Gln
Val Leu Leu Gln 305 310 315 320 Asn Lys Glu Ser Val Leu Ile Ala Leu
Glu Asn Leu Met Thr Thr Cys 325 330 335 Tyr Gly Pro Leu Pro Ser Thr
Asn Ser Tyr Glu Asn Asn Lys Thr Asp 340 345 350 Val Ser Ala Ala Asp
Ile Val Leu Ser Lys Thr Ala Glu Thr Asp Val 355 360 365 Leu Phe Asn
Lys Val Glu Ser Ser Gly Lys Asn Tyr Ser Asn Val Asp 370 375 380 Thr
Ser Val Ile Pro Phe Gln Asn Asp Met His Asn Asp Glu Ser Gly 385 390
395 400 Lys Asn Thr Asp Asp Cys Leu Asn His Gln Ile Ser Ile Gly Asp
Phe 405 410 415 Gly Tyr Gly His Cys Ser Ser Glu Ile Ser Asn Ile Asp
Lys Asn Thr 420 425 430 Lys Asn Ala Phe Gln Asp Ile Ser Met Ser Asn
Val Ser Trp Glu Asn 435 440 445 Ser Gln Thr Glu Tyr Ser Lys Thr Cys
Phe Ile Ser Ser Val Lys His 450 455 460 Thr Gln Ser Glu Asn Gly Asn
Lys Asp His Ile Asp Glu Ser Gly Glu 465 470 475 480 Asn Glu Glu Glu
Ala Gly Leu Glu Asn Ser Ser Glu Ile Ser Ala Asp 485 490 495 Glu Trp
Ser Arg Gly Asn Ile Leu Lys Asn Ser Val Gly Glu Asn Ile 500 505 510
Glu Pro Val Lys Ile Leu Val Pro Glu Lys Ser Leu Pro Cys Lys Val 515
520 525 Ser Asn Asn Asn Tyr Pro Ile Pro Glu Gln Met Asn Leu Asn Glu
Asp 530 535 540 Ser Cys Asn Lys Lys Ser Asn Val Ile Asp Asn Lys Ser
Gly Lys Val 545 550 555 560 Thr Ala Tyr Asp Leu Leu Ser Asn Arg Val
Ile Lys Lys Pro Met Ser 565 570 575 Ala Ser Ala Leu Phe Val Gln Asp
His Arg Pro Gln Phe Leu Ile Glu 580 585 590 Asn Pro Lys Thr Ser Leu
Glu Asp Ala Thr Leu Gln Ile Glu Glu Leu 595 600 605 Trp Lys Thr Leu
Ser Glu Glu Glu Lys Leu Lys Tyr Glu Glu Lys Ala 610 615 620 Thr Lys
Asp Leu Glu Arg Tyr Asn Ser Gln Met Lys Arg Ala Ile Glu 625 630 635
640 Gln Glu Ser Gln Met Ser Leu Lys Asp Gly Arg Lys Lys Ile Lys Pro
645 650 655 Thr Ser Ala Trp Asn Leu Ala Gln Lys His Lys Leu Lys Thr
Ser Leu 660 665 670 Ser Asn Gln Pro Lys Leu Asp Glu Leu Leu Gln Ser
Gln Ile Glu Lys 675 680 685 Arg Arg Ser Gln Asn Ile Lys Met Val Gln
Ile Pro Phe Ser Met Lys 690 695 700 Asn Leu Lys Ile Asn Phe Lys Lys
Gln Asn Lys Val Asp Leu Glu Glu 705 710 715 720 Lys Asp Glu Pro Cys
Leu Ile His Asn Leu Arg Phe Pro Asp Ala Trp 725 730 735 Leu Met Thr
Ser Lys Thr Glu Val Met Leu Leu Asn Pro Tyr Arg Val 740 745 750 Glu
Glu Ala Leu Leu Phe Lys Arg Leu Leu Glu Asn His Lys Leu Pro 755 760
765 Ala Glu Pro Leu Glu Lys Pro Ile Met Leu Thr Glu Ser Leu Phe Asn
770 775 780 Gly Ser His Tyr Leu Asp Val Leu Tyr Lys Met Thr Ala Asp
Asp Gln 785 790 795 800 Arg Tyr Ser Gly Ser Thr Tyr Leu Ser Asp Pro
Arg Leu Thr Ala Asn 805 810 815 Gly Phe Lys Ile Lys Leu Ile Pro Gly
Val Ser Ile Thr Glu Asn Tyr 820 825 830 Leu Glu Ile Glu Gly Met Ala
Asn Cys Leu Pro Phe Tyr Gly Val Ala 835 840 845 Asp Leu Lys Glu Ile
Leu Asn Ala Ile Leu Asn Arg Asn Ala Lys Glu 850 855 860 Val Tyr Glu
Cys Arg Pro Arg Lys Val Ile Ser Tyr Leu Glu Gly Glu 865 870 875 880
Ala Val Arg Leu Ser Arg Gln Leu Pro Met Tyr Leu Ser Lys Glu Asp 885
890 895 Ile Gln Asp Ile Ile Tyr Arg Met Lys His Gln Phe Gly Asn Glu
Ile 900 905 910 Lys Glu Cys Val His Gly Arg Pro Phe Phe His His Leu
Thr Tyr Leu 915 920 925 Pro Glu Thr Thr 930 <210> SEQ ID NO 3
<211> LENGTH: 2771 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 3 cgaggcggat
cgggtgttgc atccatggag cgagctgaga gctcgagtac agaacctgct 60
aaggccatca aacctattga tcggaagtca gtccatcaga tttgctctgg gcaggtggta
120 ctgagtctaa gcactgcggt aaaggagtta gtagaaaaca gtctggatgc
tggtgccact 180 aatattgatc taaagcttaa ggactatgga gtggatctta
ttgaagtttc agacaatgga 240 tgtggggtag aagaagaaaa cttcgaaggc
ttaactctga aacatcacac atctaagatt 300 caagagtttg ccgacctaac
tcaggttgaa acttttggct ttcgggggga agctctgagc 360 tcactttgtg
cactgagcga tgtcaccatt tctacctgcc acgcatcggc gaaggttgga 420
actcgactga tgtttgatca caatgggaaa attatccaga aaacccccta cccccgcccc
480 agagggacca cagtcagcgt gcagcagtta ttttccacac tacctgtgcg
ccataaggaa 540 tttcaaagga atattaagaa ggagtatgcc aaaatggtcc
aggtcttaca tgcatactgt 600 atcatttcag caggcatccg tgtaagttgc
accaatcagc ttggacaagg aaaacgacag 660 cctgtggtat gcacaggtgg
aagccccagc ataaaggaaa atatcggctc tgtgtttggg 720 cagaagcagt
tgcaaagcct cattcctttt gttcagctgc cccctagtga ctccgtgtgt 780
gaagagtacg gtttgagctg ttcggatgct ctgcataatc ttttttacat ctcaggtttc
840 atttcacaat gcacgcatgg agttggaagg agttcaacag acagacagtt
tttctttatc 900 aaccggcggc cttgtgaccc agcaaaggtc tgcagactcg
tgaatgaggt ctaccacatg 960 tataatcgac accagtatcc atttgttgtt
cttaacattt ctgttgattc agaatgcgtt 1020 gatatcaatg ttactccaga
taaaaggcaa attttgctac aagaggaaaa gcttttgttg 1080 gcagttttaa
agacctcttt gataggaatg tttgatagtg atgtcaacaa gctaaatgtc 1140
agtcagcagc cactgctgga tgttgaaggt aacttaataa aaatgcatgc agcggatttg
1200 gaaaagccca tggtagaaaa gcaggatcaa tccccttcat taaggactgg
agaagaaaaa 1260 aaagacgtgt ccatttccag actgcgagag gccttttctc
ttcgtcacac aacagagaac 1320 aagcctcaca gcccaaagac tccagaacca
agaaggagcc ctctaggaca gaaaaggggt 1380 atgctgtctt ctagcacttc
aggtgccatc tctgacaaag gcgtcctgag acctcagaaa 1440 gaggcagtga
gttccagtca cggacccagt gaccctacgg acagagcgga ggtggagaag 1500
gactcggggc acggcagcac ttccgtggat tctgaggggt tcagcatccc agacacgggc
1560 agtcactgca gcagcgagta tgcggccagc tccccagggg acaggggctc
gcaggaacat 1620 gtggactctc aggagaaagc gcctgaaact gacgactctt
tttcagatgt ggactgccat 1680 tcaaaccagg aagataccgg atgtaaattt
cgagttttgc ctcagccaac taatctcgca 1740 accccaaaca caaagcgttt
taaaaaagaa gaaattcttt ccagttctga catttgtcaa 1800 aagttagtaa
atactcagga catgtcagcc tctcaggttg atgtagctgt gaaaattaat 1860
aagaaagttg tgcccctgga cttttctatg agttctttag ctaaacgaat aaagcagtta
1920 catcatgaag cacagcaaag tgaaggggaa cagaattaca ggaagtttag
ggcaaagatt 1980 tgtcctggag aaaatcaagc agccgaagat gaactaagaa
aagagataag taaaacgatg 2040 tttgcagaaa tggaaatcat tggtcagttt
aacctgggat ttataataac caaactgaat 2100 gaggatatct tcatagtgga
ccagcatgcc acggacgaga agtataactt cgagatgctg 2160 cagcagcaca
ccgtgctcca ggggcagagg ctcatagcac ctcagactct caacttaact 2220
gctgttaatg aagctgttct gatagaaaat ctggaaatat ttagaaagaa tggctttgat
2280 tttgttatcg atgaaaatgc tccagtcact gaaagggcta aactgatttc
cttgccaact 2340 agtaaaaact ggaccttcgg accccaggac gtcgatgaac
tgatcttcat gctgagcgac 2400 agccctgggg tcatgtgccg gccttcccga
gtcaagcaga tgtttgcctc cagagcctgc 2460 cggaagtcgg tgatgattgg
gactgctctt aacacaagcg agatgaagaa actgatcacc 2520 cacatggggg
agatggacca cccctggaac tgtccccatg gaaggccaac catgagacac 2580
atcgccaacc tgggtgtcat ttctcagaac tgaccgtagt cactgtatgg aataattggt
2640 tttatcgcag atttttatgt tttgaaagac agagtcttca ctaacctttt
ttgttttaaa 2700 atgaaacctg ctacttaaaa aaaatacaca tcacacccat
ttaaaagtga tcttgagaac 2760 cttttcaaac c 2771 <210> SEQ ID NO
4 <211> LENGTH: 862 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 4 Met Glu Arg Ala Glu
Ser Ser Ser Thr Glu Pro Ala Lys Ala Ile Lys 1 5 10 15 Pro Ile Asp
Arg Lys Ser Val His Gln Ile Cys Ser Gly Gln Val Val 20 25 30 Leu
Ser Leu Ser Thr Ala Val Lys Glu Leu Val Glu Asn Ser Leu Asp 35 40
45 Ala Gly Ala Thr Asn Ile Asp Leu Lys Leu Lys Asp Tyr Gly Val Asp
50 55 60 Leu Ile Glu Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu
Asn Phe 65 70 75 80 Glu Gly Leu Thr Leu Lys His His Thr Ser Lys Ile
Gln Glu Phe Ala 85 90 95 Asp Leu Thr Gln Val Glu Thr Phe Gly Phe
Arg Gly Glu Ala Leu Ser 100 105 110 Ser Leu Cys Ala Leu Ser Asp Val
Thr Ile Ser Thr Cys His Ala Ser 115 120 125 Ala Lys Val Gly Thr Arg
Leu Met Phe Asp His Asn Gly Lys Ile Ile 130 135 140 Gln Lys Thr Pro
Tyr Pro Arg Pro Arg Gly Thr Thr Val Ser Val Gln 145 150 155 160 Gln
Leu Phe Ser Thr Leu Pro Val Arg His Lys Glu Phe Gln Arg Asn 165 170
175 Ile Lys Lys Glu Tyr Ala Lys Met Val Gln Val Leu His Ala Tyr Cys
180 185 190 Ile Ile Ser Ala Gly Ile Arg Val Ser Cys Thr Asn Gln Leu
Gly Gln 195 200 205 Gly Lys Arg Gln Pro Val Val Cys Thr Gly Gly Ser
Pro Ser Ile Lys 210 215 220 Glu Asn Ile Gly Ser Val Phe Gly Gln Lys
Gln Leu Gln Ser Leu Ile 225 230 235 240 Pro Phe Val Gln Leu Pro Pro
Ser Asp Ser Val Cys Glu Glu Tyr Gly 245 250 255 Leu Ser Cys Ser Asp
Ala Leu His Asn Leu Phe Tyr Ile Ser Gly Phe 260 265 270 Ile Ser Gln
Cys Thr His Gly Val Gly Arg Ser Ser Thr Asp Arg Gln 275 280 285 Phe
Phe Phe Ile Asn Arg Arg Pro Cys Asp Pro Ala Lys Val Cys Arg 290 295
300 Leu Val Asn Glu Val Tyr His Met Tyr Asn Arg His Gln Tyr Pro Phe
305 310 315 320 Val Val Leu Asn Ile Ser Val Asp Ser Glu Cys Val Asp
Ile Asn Val 325 330 335 Thr Pro Asp Lys Arg Gln Ile Leu Leu Gln Glu
Glu Lys Leu Leu Leu 340 345 350 Ala Val Leu Lys Thr Ser Leu Ile Gly
Met Phe Asp Ser Asp Val Asn 355 360 365 Lys Leu Asn Val Ser Gln Gln
Pro Leu Leu Asp Val Glu Gly Asn Leu 370 375 380 Ile Lys Met His Ala
Ala Asp Leu Glu Lys Pro Met Val Glu Lys Gln 385 390 395 400 Asp Gln
Ser Pro Ser Leu Arg Thr Gly Glu Glu Lys Lys Asp Val Ser 405 410 415
Ile Ser Arg Leu Arg Glu Ala Phe Ser Leu Arg His Thr Thr Glu Asn 420
425 430 Lys Pro His Ser Pro Lys Thr Pro Glu Pro Arg Arg Ser Pro Leu
Gly 435 440 445 Gln Lys Arg Gly Met Leu Ser Ser Ser Thr Ser Gly Ala
Ile Ser Asp 450 455 460 Lys Gly Val Leu Arg Pro Gln Lys Glu Ala Val
Ser Ser Ser His Gly 465 470 475 480 Pro Ser Asp Pro Thr Asp Arg Ala
Glu Val Glu Lys Asp Ser Gly His 485 490 495 Gly Ser Thr Ser Val Asp
Ser Glu Gly Phe Ser Ile Pro Asp Thr Gly 500 505 510 Ser His Cys Ser
Ser Glu Tyr Ala Ala Ser Ser Pro Gly Asp Arg Gly 515 520 525 Ser Gln
Glu His Val Asp Ser Gln Glu Lys Ala Pro Glu Thr Asp Asp 530 535 540
Ser Phe Ser Asp Val Asp Cys His Ser Asn Gln Glu Asp Thr Gly Cys 545
550 555 560 Lys Phe Arg Val Leu Pro Gln Pro Thr Asn Leu Ala Thr Pro
Asn Thr 565 570 575 Lys Arg Phe Lys Lys Glu Glu Ile Leu Ser Ser Ser
Asp Ile Cys Gln 580 585 590 Lys Leu Val Asn Thr Gln Asp Met Ser Ala
Ser Gln Val Asp Val Ala 595 600 605 Val Lys Ile Asn Lys Lys Val Val
Pro Leu Asp Phe Ser Met Ser Ser 610 615 620 Leu Ala Lys Arg Ile Lys
Gln Leu His His Glu Ala Gln Gln Ser Glu 625 630 635 640 Gly Glu Gln
Asn Tyr Arg Lys Phe Arg Ala Lys Ile Cys Pro Gly Glu 645 650 655 Asn
Gln Ala Ala Glu Asp Glu Leu Arg Lys Glu Ile Ser Lys Thr Met 660 665
670 Phe Ala Glu Met Glu Ile Ile Gly Gln Phe Asn Leu Gly Phe Ile Ile
675 680 685 Thr Lys Leu Asn Glu Asp Ile Phe Ile Val Asp Gln His Ala
Thr Asp 690 695 700 Glu Lys Tyr Asn Phe Glu Met Leu Gln Gln His Thr
Val Leu Gln Gly 705 710 715 720 Gln Arg Leu Ile Ala Pro Gln Thr Leu
Asn Leu Thr Ala Val Asn Glu 725 730 735 Ala Val Leu Ile Glu Asn Leu
Glu Ile Phe Arg Lys Asn Gly Phe Asp 740 745 750 Phe Val Ile Asp Glu
Asn Ala Pro Val Thr Glu Arg Ala Lys Leu Ile 755 760 765 Ser Leu Pro
Thr Ser Lys Asn Trp Thr Phe Gly Pro Gln Asp Val Asp 770 775 780 Glu
Leu Ile Phe Met Leu Ser Asp Ser Pro Gly Val Met Cys Arg Pro 785 790
795 800 Ser Arg Val Lys Gln Met Phe Ala Ser Arg Ala Cys Arg Lys Ser
Val 805 810 815 Met Ile Gly Thr Ala Leu Asn Thr Ser Glu Met Lys Lys
Leu Ile Thr 820 825 830 His Met Gly Glu Met Asp His Pro Trp Asn Cys
Pro His Gly Arg Pro 835 840 845 Thr Met Arg His Ile Ala Asn Leu Gly
Val Ile Ser Gln Asn 850 855 860 <210> SEQ ID NO 5 <211>
LENGTH: 426 <212> TYPE: DNA <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 5 cgaggcggat cgggtgttgc atccatggag
cgagctgaga gctcgagtac agaacctgct 60 aaggccatca aacctattga
tcggaagtca gtccatcaga tttgctctgg gcaggtggta 120 ctgagtctaa
gcactgcggt aaaggagtta gtagaaaaca gtctggatgc tggtgccact 180
aatattgatc taaagcttaa ggactatgga gtggatctta ttgaagtttc agacaatgga
240 tgtggggtag aagaagaaaa cttcgaaggc ttaactctga aacatcacac
atctaagatt 300 caagagtttg ccgacctaac tcaggttgaa acttttggct
ttcgggggga agctctgagc 360 tcactttgtg cactgagcga tgtcaccatt
tctacctgcc acgcatcggc gaaggttgga 420 acttga 426 <210> SEQ ID
NO 6 <211> LENGTH: 133 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 6 Met Glu Arg Ala Glu
Ser Ser Ser Thr Glu Pro Ala Lys Ala Ile Lys 1 5 10 15 Pro Ile Asp
Arg Lys Ser Val His Gln Ile Cys Ser Gly Gln Val Val 20 25 30 Leu
Ser Leu Ser Thr Ala Val Lys Glu Leu Val Glu Asn Ser Leu Asp 35 40
45 Ala Gly Ala Thr Asn Ile Asp Leu Lys Leu Lys Asp Tyr Gly Val Asp
50 55 60 Leu Ile Glu Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu
Asn Phe 65 70 75 80 Glu Gly Leu Thr Leu Lys His His Thr Ser Lys Ile
Gln Glu Phe Ala 85 90 95 Asp Leu Thr Gln Val Glu Thr Phe Gly Phe
Arg Gly Glu Ala Leu Ser 100 105 110 Ser Leu Cys Ala Leu Ser Asp Val
Thr Ile Ser Thr Cys His Ala Ser 115 120 125 Ala Lys Val Gly Thr 130
<210> SEQ ID NO 7 <211> LENGTH: 1408 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 7
ggcgctccta cctgcaagtg gctagtgcca agtgctgggc cgccgctcct gccgtgcatg
60 ttggggagcc agtacatgca ggtgggctcc acacggagag gggcgcagac
ccggtgacag 120 ggctttacct ggtacatcgg catggcgcaa ccaaagcaag
agagggtggc gcgtgccaga 180 caccaacggt cggaaaccgc cagacaccaa
cggtcggaaa ccgccaagac accaacgctc 240 ggaaaccgcc agacaccaac
gctcggaaac cgccagacac caaggctcgg aatccacgcc 300 aggccacgac
ggagggcgac tacctccctt ctgaccctgc tgctggcgtt cggaaaaaac 360
gcagtccggt gtgctctgat tggtccaggc tctttgacgt cacggactcg acctttgaca
420 gagccactag gcgaaaagga gagacgggaa gtattttttc cgccccgccc
ggaaagggtg 480 gagcacaacg tcgaaagcag ccgttgggag cccaggaggc
ggggcgcctg tgggagccgt 540 ggagggaact ttcccagtcc ccgaggcgga
tccggtgttg catccttgga gcgagctgag 600 aactcgagta cagaacctgc
taaggccatc aaacctattg atcggaagtc agtccatcag 660 atttgctctg
ggccggtggt accgagtcta aggccgaatg cggtgaagga gttagtagaa 720
aacagtctgg atgctggtgc cactaatgtt gatctaaagc ttaaggacta tggagtggat
780 ctcattgaag tttcaggcaa tggatgtggg gtagaagaag aaaacttcga
aggctttact 840 ctgaaacatc acacatgtaa gattcaagag tttgccgacc
taactcaggt ggaaactttt 900 ggctttcggg gggaagctct gagctcactt
tgtgcactga gtgatgtcac catttctacc 960 tgccgtgtat cagcgaaggt
tgggactcga ctggtgtttg atcactatgg gaaaatcatc 1020 cagaaaaccc
cctacccccg ccccagaggg atgacagtca gcgtgaagca gttattttct 1080
acgctacctg tgcaccataa agaatttcaa aggaatatta agaagaaacg tgcctgcttc
1140 cccttcgcct tctgccgtga ttgtcagttt cctgaggcct ccccagccat
gcttcctgta 1200 cagcctgtag aactgactcc tagaagtacc ccaccccacc
cctgctcctt ggaggacaac 1260 gtgatcactg tattcagctc tgtcaagaat
ggtccaggtt cttctagatg atctgcacaa 1320 atggttcctc tcctccttcc
tgatgtctgc cattagcatt ggaataaagt tcctgctgaa 1380 aatccaaaaa
aaaaaaaaaa aaaaaaaa 1408 <210> SEQ ID NO 8 <211>
LENGTH: 389 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 8 Met Ala Gln Pro Lys Gln Glu Arg Val
Ala Arg Ala Arg His Gln Arg 1 5 10 15 Ser Glu Thr Ala Arg His Gln
Arg Ser Glu Thr Ala Lys Thr Pro Thr 20 25 30 Leu Gly Asn Arg Gln
Thr Pro Thr Leu Gly Asn Arg Gln Thr Pro Arg 35 40 45 Leu Gly Ile
His Ala Arg Pro Arg Arg Arg Ala Thr Thr Ser Leu Leu 50 55 60 Thr
Leu Leu Leu Ala Phe Gly Lys Asn Ala Val Arg Cys Ala Leu Ile 65 70
75 80 Gly Pro Gly Ser Leu Thr Ser Arg Thr Arg Pro Leu Thr Glu Pro
Leu 85 90 95 Gly Glu Lys Glu Arg Arg Glu Val Phe Phe Pro Pro Arg
Pro Glu Arg 100 105 110 Val Glu His Asn Val Glu Ser Ser Arg Trp Glu
Pro Arg Arg Arg Gly 115 120 125 Ala Cys Gly Ser Arg Gly Gly Asn Phe
Pro Ser Pro Arg Gly Gly Ser 130 135 140 Gly Val Ala Ser Leu Glu Arg
Ala Glu Asn Ser Ser Thr Glu Pro Ala 145 150 155 160 Lys Ala Ile Lys
Pro Ile Asp Arg Lys Ser Val His Gln Ile Cys Ser 165 170 175 Gly Pro
Val Val Pro Ser Leu Arg Pro Asn Ala Val Lys Glu Leu Val 180 185 190
Glu Asn Ser Leu Asp Ala Gly Ala Thr Asn Val Asp Leu Lys Leu Lys 195
200 205 Asp Tyr Gly Val Asp Leu Ile Glu Val Ser Gly Asn Gly Cys Gly
Val 210 215 220 Glu Glu Glu Asn Phe Glu Gly Phe Thr Leu Lys His His
Thr Cys Lys 225 230 235 240 Ile Gln Glu Phe Ala Asp Leu Thr Gln Val
Glu Thr Phe Gly Phe Arg 245 250 255 Gly Glu Ala Leu Ser Ser Leu Cys
Ala Leu Ser Asp Val Thr Ile Ser 260 265 270 Thr Cys Arg Val Ser Ala
Lys Val Gly Thr Arg Leu Val Phe Asp His 275 280 285 Tyr Gly Lys Ile
Ile Gln Lys Thr Pro Tyr Pro Arg Pro Arg Gly Met 290 295 300 Thr Val
Ser Val Lys Gln Leu Phe Ser Thr Leu Pro Val His His Lys 305 310 315
320 Glu Phe Gln Arg Asn Ile Lys Lys Lys Arg Ala Cys Phe Pro Phe Ala
325 330 335 Phe Cys Arg Asp Cys Gln Phe Pro Glu Ala Ser Pro Ala Met
Leu Pro 340 345 350 Val Gln Pro Val Glu Leu Thr Pro Arg Ser Thr Pro
Pro His Pro Cys 355 360 365 Ser Leu Glu Asp Asn Val Ile Thr Val Phe
Ser Ser Val Lys Asn Gly 370 375 380 Pro Gly Ser Ser Arg 385
<210> SEQ ID NO 9 <211> LENGTH: 1785 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 9
tttttagaaa ctgatgttta ttttccatca accatttttc catgctgctt aagagaatat
60 gcaagaacag cttaagacca gtcagtggtt gctcctaccc attcagtggc
ctgagcagtg 120 gggagctgca gaccagtctt ccgtggcagg ctgagcgctc
cagtcttcag tagggaattg 180 ctgaataggc acagagggca cctgtacacc
ttcagaccag tctgcaacct caggctgagt 240 agcagtgaac tcaggagcgg
gagcagtcca ttcaccctga aattcctcct tggtcactgc 300 cttctcagca
gcagcctgct cttctttttc aatctcttca ggatctctgt agaagtacag 360
atcaggcatg acctcccatg ggtgttcacg ggaaatggtg ccacgcatgc gcagaacttc
420 ccgagccagc atccaccaca ttaaacccac tgagtgagct cccttgttgt
tgcatgggat 480 ggcaatgtcc acatagcgca gaggagaatc tgtgttacac
agcgcaatgg taggtaggtt 540 aacataagat gcctccgtga gaggcgaagg
ggcggcggga cccgggcctg gcccgtatgt 600 gtccttggcg gcctagacta
ggccgtcgct gtatggtgag ccccagggag gcggatctgg 660 gcccccagaa
ggacacccgc ctggatttgc cccgtagccc ggcccgggcc cctcgggagc 720
agaacagcct tggtgaggtg gacaggaggg gacctcgcga gcagacgcgc gcgccagcga
780 cagcagcccc gccccggcct ctcgggagcc ggggggcaga ggctgcggag
ccccaggagg 840 gtctatcagc cacagtctct gcatgtttcc aagagcaaca
ggaaatgaac acattgcagg 900 ggccagtgtc attcaaagat gtggctgtgg
atttcaccca ggaggagtgg cggcaactgg 960 accctgatga gaagatagca
tacggggatg tgatgttgga gaactacagc catctagttt 1020 ctgtggggta
tgattatcac caagccaaac atcatcatgg agtggaggtg aaggaagtgg 1080
agcagggaga ggagccgtgg ataatggaag gtgaatttcc atgtcaacat agtccagaac
1140 ctgctaaggc catcaaacct attgatcgga agtcagtcca tcagatttgc
tctgggccag 1200 tggtactgag tctaagcact gcagtgaagg agttagtaga
aaacagtctg gatgctggtg 1260 ccactaatat tgatctaaag cttaaggact
atggagtgga tctcattgaa gtttcagaca 1320 atggatgtgg ggtagaagaa
gaaaactttg aaggcttaat ctctttcagc tctgaaacat 1380 cacacatgta
agattcaaga gtttgccgac ctaactgaag ttgaaacttt cggttttcag 1440
ggggaagctc tgagctcact gtgtgcactg agcgatgtca ccatttctac ctgccacgcg
1500 ttggtgaagg ttgggactcg actggtgttt gatcacgatg ggaaaatcat
ccaggaaacc 1560 ccctaccccc accccagagg gaccacagtc agcgtgaagc
agttattttc tacgctacct 1620 gtgcgccata aggaatttca aaggaatatt
aagaagacgt gcctgcttcc ccttcgcctt 1680 ctgccgtgat tgtcagtttc
ctgaggcctc cccagccatg cttcctgtac agcctgcaga 1740 actgtgagtc
aattaaacct cttttcttca taaattaaaa aaaaa 1785 <210> SEQ ID NO
10 <211> LENGTH: 264 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 10 Met Cys Pro Trp Arg
Pro Arg Leu Gly Arg Arg Cys Met Val Ser Pro 1 5 10 15 Arg Glu Ala
Asp Leu Gly Pro Gln Lys Asp Thr Arg Leu Asp Leu Pro 20 25 30 Arg
Ser Pro Ala Arg Ala Pro Arg Glu Gln Asn Ser Leu Gly Glu Val 35 40
45 Asp Arg Arg Gly Pro Arg Glu Gln Thr Arg Ala Pro Ala Thr Ala Ala
50 55 60 Pro Pro Arg Pro Leu Gly Ser Arg Gly Ala Glu Ala Ala Glu
Pro Gln 65 70 75 80 Glu Gly Leu Ser Ala Thr Val Ser Ala Cys Phe Gln
Glu Gln Gln Glu 85 90 95 Met Asn Thr Leu Gln Gly Pro Val Ser Phe
Lys Asp Val Ala Val Asp 100 105 110 Phe Thr Gln Glu Glu Trp Arg Gln
Leu Asp Pro Asp Glu Lys Ile Ala 115 120 125 Tyr Gly Asp Val Met Leu
Glu Asn Tyr Ser His Leu Val Ser Val Gly 130 135 140 Tyr Asp Tyr His
Gln Ala Lys His His His Gly Val Glu Val Lys Glu 145 150 155 160 Val
Glu Gln Gly Glu Glu Pro Trp Ile Met Glu Gly Glu Phe Pro Cys 165 170
175 Gln His Ser Pro Glu Pro Ala Lys Ala Ile Lys Pro Ile Asp Arg Lys
180 185 190 Ser Val His Gln Ile Cys Ser Gly Pro Val Val Leu Ser Leu
Ser Thr 195 200 205 Ala Val Lys Glu Leu Val Glu Asn Ser Leu Asp Ala
Gly Ala Thr Asn 210 215 220 Ile Asp Leu Lys Leu Lys Asp Tyr Gly Val
Asp Leu Ile Glu Val Ser 225 230 235 240 Asp Asn Gly Cys Gly Val Glu
Glu Glu Asn Phe Glu Gly Leu Ile Ser 245 250 255 Phe Ser Ser Glu Thr
Ser His Met 260 <210> SEQ ID NO 11 <211> LENGTH: 2271
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 11 atgtcgttcg tggcaggggt tattcggcgg
ctggacgaga cagtggtgaa ccgcatcgcg 60 gcgggggaag ttatccagcg
gccagctaat gctatcaaag agatgattga gaactgttta 120 gatgcaaaat
ccacaagtat tcaagtgatt gttaaagagg gaggcctgaa gttgattcag 180
atccaagaca atggcaccgg gatcaggaaa gaagatctgg atattgtatg tgaaaggttc
240 actactagta aactgcagtc ctttgaggat ttagccagta tttctaccta
tggctttcga 300 ggtgaggctt tggccagcat aagccatgtg gctcatgtta
ctattacaac gaaaacagct 360 gatggaaagt gtgcatacag agcaagttac
tcagatggaa aactgaaagc ccctcctaaa 420 ccatgtgctg gcaatcaagg
gacccagatc acggtggagg acctttttta caacatagcc 480 acgaggagaa
aagctttaaa aaatccaagt gaagaatatg ggaaaatttt ggaagttgtt 540
ggcaggtatt cagtacacaa tgcaggcatt agtttctcag ttaaaaaaca aggagagaca
600 gtagctgatg ttaggacact acccaatgcc tcaaccgtgg acaatattcg
ctccatcttt 660 ggaaatgctg ttagtcgaga actgatagaa attggatgtg
aggataaaac cctagccttc 720 aaaatgaatg gttacatatc caatgcaaac
tactcagtga agaagtgcat cttcttactc 780 ttcatcaacc atcgtctggt
agaatcaact tccttgagaa aagccataga aacagtgtat 840 gcagcctatt
tgcccaaaaa cacacaccca ttcctgtacc tcagtttaga aatcagtccc 900
cagaatgtgg atgttaatgt gcaccccaca aagcatgaag ttcacttcct gcacgaggag
960 agcatcctgg agcgggtgca gcagcacatc gagagcaagc tcctgggctc
caattcctcc 1020 aggatgtact tcacccagac tttgctacca ggacttgctg
gcccctctgg ggagatggtt 1080 aaatccacaa caagtctgac ctcgtcttct
acttctggaa gtagtgataa ggtctatgcc 1140 caccagatgg ttcgtacaga
ttcccgggaa cagaagcttg atgcatttct gcagcctctg 1200 agcaaacccc
tgtccagtca gccccaggcc attgtcacag aggataagac agatatttct 1260
agtggcaggg ctaggcagca agatgaggag atgcttgaac tcccagcccc tgctgaagtg
1320 gctgccaaaa atcagagctt ggagggggat acaacaaagg ggacttcaga
aatgtcagag 1380 aagagaggac ctacttccag caaccccaga aagagacatc
gggaagattc tgatgtggaa 1440 atggtggaag atgattcccg aaaggaaatg
actgcagctt gtaccccccg gagaaggatc 1500 attaacctca ctagtgtttt
gagtctccag gaagaaatta atgagcaggg acatgaggtt 1560 ctccgggaga
tgttgcataa ccactccttc gtgggctgtg tgaatcctca gtgggccttg 1620
gcacagcatc aaaccaagtt ataccttctc aacaccacca agcttagtga agaactgttc
1680 taccagatac tcatttatga ttttgccaat tttggtgttc tcaggttatc
ggagccagca 1740 ccgctctttg accttgccat gcttgcctta gatagtccag
agagtggctg gacagaggaa 1800 gatggtccca aagaaggact tgctgaatac
attgttgagt ttctgaagaa gaaggctgag 1860 atgcttgcag actatttctc
tttggaaatt gatgaggaag ggaacctgat tggattaccc 1920 cttctgattg
acaactatgt gccccctttg gagggactgc ctatcttcat tcttcgacta 1980
gccactgagg tgaattggga cgaagaaaag gaatgttttg aaagcctcag taaagaatgc
2040 gctatgttct attccatccg gaagcagtac atatctgagg agtcgaccct
ctcaggccag 2100 cagagtgaag tgcctggctc cattccaaac tcctggaagt
ggactgtgga acacattgtc 2160 tataaagcct tgcgctcaca cattctgcct
cctaaacatt tcacagaaga tggaaatatc 2220 ctgcagcttg ctaacctgcc
tgatctatac aaagtctttg agaggtgtta a 2271 <210> SEQ ID NO 12
<211> LENGTH: 756 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 12 Met Ser Phe Val Ala Gly Val
Ile Arg Arg Leu Asp Glu Thr Val Val 1 5 10 15 Asn Arg Ile Ala Ala
Gly Glu Val Ile Gln Arg Pro Ala Asn Ala Ile 20 25 30 Lys Glu Met
Ile Glu Asn Cys Leu Asp Ala Lys Ser Thr Ser Ile Gln 35 40 45 Val
Ile Val Lys Glu Gly Gly Leu Lys Leu Ile Gln Ile Gln Asp Asn 50 55
60 Gly Thr Gly Ile Arg Lys Glu Asp Leu Asp Ile Val Cys Glu Arg Phe
65 70 75 80 Thr Thr Ser Lys Leu Gln Ser Phe Glu Asp Leu Ala Ser Ile
Ser Thr 85 90 95 Tyr Gly Phe Arg Gly Glu Ala Leu Ala Ser Ile Ser
His Val Ala His 100 105 110 Val Thr Ile Thr Thr Lys Thr Ala Asp Gly
Lys Cys Ala Tyr Arg Ala 115 120 125 Ser Tyr Ser Asp Gly Lys Leu Lys
Ala Pro Pro Lys Pro Cys Ala Gly 130 135 140 Asn Gln Gly Thr Gln Ile
Thr Val Glu Asp Leu Phe Tyr Asn Ile Ala 145 150 155 160 Thr Arg Arg
Lys Ala Leu Lys Asn Pro Ser Glu Glu Tyr Gly Lys Ile 165 170 175 Leu
Glu Val Val Gly Arg Tyr Ser Val His Asn Ala Gly Ile Ser Phe 180 185
190 Ser Val Lys Lys Gln Gly Glu Thr Val Ala Asp Val Arg Thr Leu Pro
195 200 205 Asn Ala Ser Thr Val Asp Asn Ile Arg Ser Ile Phe Gly Asn
Ala Val 210 215 220 Ser Arg Glu Leu Ile Glu Ile Gly Cys Glu Asp Lys
Thr Leu Ala Phe 225 230 235 240 Lys Met Asn Gly Tyr Ile Ser Asn Ala
Asn Tyr Ser Val Lys Lys Cys 245 250 255 Ile Phe Leu Leu Phe Ile Asn
His Arg Leu Val Glu Ser Thr Ser Leu 260 265 270 Arg Lys Ala Ile Glu
Thr Val Tyr Ala Ala Tyr Leu Pro Lys Asn Thr 275 280 285 His Pro Phe
Leu Tyr Leu Ser Leu Glu Ile Ser Pro Gln Asn Val Asp 290 295 300 Val
Asn Val His Pro Thr Lys His Glu Val His Phe Leu His Glu Glu 305 310
315 320 Ser Ile Leu Glu Arg Val Gln Gln His Ile Glu Ser Lys Leu Leu
Gly 325 330 335 Ser Asn Ser Ser Arg Met Tyr Phe Thr Gln Thr Leu Leu
Pro Gly Leu 340 345 350 Ala Gly Pro Ser Gly Glu Met Val Lys Ser Thr
Thr Ser Leu Thr Ser 355 360 365 Ser Ser Thr Ser Gly Ser Ser Asp Lys
Val Tyr Ala His Gln Met Val 370 375 380 Arg Thr Asp Ser Arg Glu Gln
Lys Leu Asp Ala Phe Leu Gln Pro Leu 385 390 395 400 Ser Lys Pro Leu
Ser Ser Gln Pro Gln Ala Ile Val Thr Glu Asp Lys 405 410 415 Thr Asp
Ile Ser Ser Gly Arg Ala Arg Gln Gln Asp Glu Glu Met Leu 420 425 430
Glu Leu Pro Ala Pro Ala Glu Val Ala Ala Lys Asn Gln Ser Leu Glu 435
440 445 Gly Asp Thr Thr Lys Gly Thr Ser Glu Met Ser Glu Lys Arg Gly
Pro 450 455 460 Thr Ser Ser Asn Pro Arg Lys Arg His Arg Glu Asp Ser
Asp Val Glu 465 470 475 480 Met Val Glu Asp Asp Ser Arg Lys Glu Met
Thr Ala Ala Cys Thr Pro 485 490 495 Arg Arg Arg Ile Ile Asn Leu Thr
Ser Val Leu Ser Leu Gln Glu Glu 500 505 510 Ile Asn Glu Gln Gly His
Glu Val Leu Arg Glu Met Leu His Asn His 515 520 525 Ser Phe Val Gly
Cys Val Asn Pro Gln Trp Ala Leu Ala Gln His Gln 530 535 540 Thr Lys
Leu Tyr Leu Leu Asn Thr Thr Lys Leu Ser Glu Glu Leu Phe 545 550 555
560 Tyr Gln Ile Leu Ile Tyr Asp Phe Ala Asn Phe Gly Val Leu Arg Leu
565 570 575 Ser Glu Pro Ala Pro Leu Phe Asp Leu Ala Met Leu Ala Leu
Asp Ser 580 585 590 Pro Glu Ser Gly Trp Thr Glu Glu Asp Gly Pro Lys
Glu Gly Leu Ala 595 600 605 Glu Tyr Ile Val Glu Phe Leu Lys Lys Lys
Ala Glu Met Leu Ala Asp 610 615 620 Tyr Phe Ser Leu Glu Ile Asp Glu
Glu Gly Asn Leu Ile Gly Leu Pro 625 630 635 640 Leu Leu Ile Asp Asn
Tyr Val Pro Pro Leu Glu Gly Leu Pro Ile Phe 645 650 655 Ile Leu Arg
Leu Ala Thr Glu Val Asn Trp Asp Glu Glu Lys Glu Cys 660 665 670 Phe
Glu Ser Leu Ser Lys Glu Cys Ala Met Phe Tyr Ser Ile Arg Lys 675 680
685 Gln Tyr Ile Ser Glu Glu Ser Thr Leu Ser Gly Gln Gln Ser Glu Val
690 695 700 Pro Gly Ser Ile Pro Asn Ser Trp Lys Trp Thr Val Glu His
Ile Val 705 710 715 720 Tyr Lys Ala Leu Arg Ser His Ile Leu Pro Pro
Lys His Phe Thr Glu 725 730 735 Asp Gly Asn Ile Leu Gln Leu Ala Asn
Leu Pro Asp Leu Tyr Lys Val 740 745 750 Phe Glu Arg Cys 755
<210> SEQ ID NO 13 <211> LENGTH: 4895 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 13
gtcggcgtcc gaggcggttg gtgtcggaga atttgttaag cgggactcca ggcaattatt
60 tccagtcaga gaaggaaacc agtgcctggc attctcacca tctttctacc
taccatgatc 120 aagtgcttgt cagttgaagt acaagccaaa ttgcgttctg
gtttggccat aagctccttg 180 ggccaatgtg ttgaggaact tgccctcaac
agtattgatg ctgaagcaaa atgtgtggct 240 gtcagggtga atatggaaac
cttccaagtt caagtgatag acaatggatt tgggatgggg 300 agtgatgatg
tagagaaagt gggaaatcgt tatttcacca gtaaatgcca ctcggtacag 360
gacttggaga atccaaggtt ttatggtttc cgaggagagg ccttggcaaa tattgctgac
420 atggccagtg ctgtggaaat ttcgtccaag aaaaacagga caatgaaaac
ttttgtgaaa 480 ctgtttcaga gtggaaaagc cctgaaagct tgtgaagctg
atgtgactag agcaagcgct 540 gggactactg taacagtgta taacctattt
taccagcttc ctgtaaggag gaaatgcatg 600 gaccctagac tggagtttga
gaaggttagg cagagaatag aagctctctc actcatgcac 660 ccttccattt
ctttctcttt gagaaatgat gtttctggtt ccatggttct tcagctccct 720
aaaaccaaag acgtatgttc ccgattttgt caaatttatg gattgggaaa gtcccaaaag
780 ctaagagaaa taagttttaa atataaagag tttgagctta gtggctatat
cagctctgaa 840 gcacattaca acaagaatat gcagtttttg tttgtgaaca
aaagactagt tttaaggaca 900 aagctacata aactcattga ctttttatta
aggaaagaaa gtattatatg caagccaaag 960 aatggtccca ccagtaggca
aatgaattca agtcttcggc accggtctac cccagaactc 1020 tatggcatat
atgtaattaa tgtgcagtgc caattctgtg agtatgatgt gtgcatggag 1080
ccagccaaaa ctctgattga atttcagaac tgggacactc tcttgttttg cattcaggaa
1140 ggagtgaaaa tgtttttaaa gcaagaaaaa ttatttgtgg aattatcagg
tgaggatatt 1200 aaggaattta gtgaagataa tggttttagt ttatttgatg
ctactcttca gaagcgtgtg 1260 acttccgatg agaggagcaa tttccaggaa
gcatgtaata atattttaga ttcctatgag 1320 atgtttaatt tgcagtcaaa
agctgtgaaa agaaaaacta ctgcagaaaa cgtaaacaca 1380 cagagttcta
gggattcaga agctaccaga aaaaatacaa atgatgcatt tttgtacatt 1440
tatgaatcag gtggtccagg ccatagcaaa atgacagagc catctttaca aaacaaagac
1500 agctcttgct cagaatcaaa gatgttagaa caagagacaa ttgtagcatc
agaagctggt 1560 gaaaatgaga aacataaaaa atctttcctg gaacgtagct
ctttagaaaa tccgtgtgga 1620 accagtttag aaatgttttt aagccctttt
cagacaccat gtcactttga ggagagtggg 1680 caggatctag aaatatggaa
agaaagtact actgttaatg gcatggctgc caacatcttg 1740 aaaaataata
gaattcagaa tcaaccaaag agatttaaag atgctactga agtgggatgc 1800
cagcctctgc cttttgcaac aacattatgg ggagtacata gtgctcagac agagaaagag
1860 aaaaaaaaag aatctagcaa ttgtggaaga agaaatgttt ttagttatgg
gcgagttaaa 1920 ttatgttcca ctggctttat aactcatgta gtacaaaatg
aaaaaactaa atcaactgaa 1980 acagaacatt catttaaaaa ttatgttaga
cctggtccca cacgtgccca agaaacattt 2040 ggaaatagaa cacgtcattc
agttgaaact ccagacatca aagatttagc cagcacttta 2100 agtaaagaat
ctggtcaatt gcccaacaaa aaaaattgca gaacgaatat aagttatggg 2160
ctagagaatg aacctacagc aacttataca atgttttctg cttttcagga aggtagcaaa
2220 aaatcacaaa cagattgcat attatctgat acatccccct ctttcccctg
gtatagacac 2280 gtttccaatg atagtaggaa aacagataaa ttaattggtt
tctccaaacc aatcgtccgt 2340 aagaagctaa gcttgagttc acagctagga
tctttagaga agtttaagag gcaatatggg 2400 aaggttgaaa atcctctgga
tacagaagta gaggaaagta atggagtcac taccaatctc 2460 agtcttcaag
ttgaacctga cattctgctg aaggacaaga accgcttaga gaactctgat 2520
gtttgtaaaa tcactactat ggagcatagt gattcagata gtagttgtca accagcaagc
2580 cacatccttg actcagagaa gtttccattc tccaaggatg aagattgttt
agaacaacag 2640 atgcctagtt tgagagaaag tcctatgacc ctgaaggagt
tatctctctt taatagaaaa 2700 cctttggacc ttgagaagtc atctgaatca
ctagcctcta aattatccag actgaagggt 2760 tccgaaagag aaactcaaac
aatggggatg atgagtcgtt ttaatgaact tccaaattca 2820 gattccagta
ggaaagacag caagttgtgc agtgtgttaa cacaagattt ttgtatgtta 2880
tttaacaaca agcatgaaaa aacagagaat ggtgtcatcc caacatcaga ttctgccaca
2940 caggataatt cctttaataa aaatagtaaa acacattcta acagcaatac
aacagagaac 3000 tgtgtgatat cagaaactcc tttggtattg ccctataata
attctaaagt taccggtaaa 3060 gattcagatg ttcttatcag agcctcagaa
caacagatag gaagtcttga ctctcccagt 3120 ggaatgttaa tgaatccggt
agaagatgcc acaggtgacc aaaatggaat ttgttttcag 3180 agtgaggaat
ctaaagcaag agcttgttct gaaactgaag agtcaaacac gtgttgttca 3240
gattggcagc ggcatttcga tgtagccctg ggaagaatgg tttatgtcaa caaaatgact
3300 ggactcagca cattcattgc cccaactgag gacattcagg ctgcttgtac
taaagacctg 3360 acaactgtgg ctgtggatgt tgtacttgag aatgggtctc
agtacaggtg tcaacctttt 3420 agaagcgacc ttgttcttcc tttccttccg
agagctcgag cagagaggac tgtgatgaga 3480 caggataaca gagatactgt
ggatgatact gttagtagcg aatcgcttca gtctttgttc 3540 tcagaatggg
acaatccagt atttgcccgt tatccagagg ttgctgttga tgtaagcagt 3600
ggccaggctg agagcttagc agttaaaatt cacaacatct tgtatcccta tcgtttcacc
3660 aaaggaatga ttcattcaat gcaggttctc cagcaagtag ataacaagtt
tattgcctgt 3720 ttgatgagca ctaagactga agagaatggc gaggcagatt
cctacgagaa gcaacaggca 3780 caaggctctg gtcggaaaaa attactgtct
tctactctaa ttcctccgct agagataaca 3840 gtgacagagg aacaaaggag
actcttatgg tgttaccaca aaaatctgga agatctgggc 3900 cttgaatttg
tatttccaga cactagtgat tctctggtcc ttgtgggaaa agtaccacta 3960
tgttttgtgg aaagagaagc caatgaactt cggagaggaa gatctactgt gaccaagagt
4020 attgtggagg aatttatccg agaacaactg gagctactcc agaccaccgg
aggcatccaa 4080 gggacattgc cactgactgt ccagaaggtg ttggcatccc
aagcctgcca tggggccatt 4140 aagtttaatg atggcctgag cttacaggaa
agttgccgcc ttattgaagc tctgtcctca 4200 tgccagctgc cattccagtg
tgctcacggg agaccttcta tgctgccgtt agctgacata 4260 gaccacttgg
aacaggaaaa acagattaaa cccaacctca ctaaacttcg caaaatggcc 4320
caggcctggc gtctctttgg aaaagcagag tgtgatacaa ggcagagcct gcagcagtcc
4380 atgcctccct gtgagccacc atgagaacag aatcactggt ctaaaaggaa
caaagggatg 4440 ttcactgtat gcctctgagc agagagcagc agcagcaggt
accagcacgg ccctgactga 4500 atcagcccag tgtccctgag cagcttagac
agcagggctc tctgtatcag tctttcttga 4560 gcagatgatt cccctagttg
agtagccaga tgaaattcaa gcctaaagac aattcattca 4620 tttgcatcca
tgggcacaga aggttgctat atagtatcta ccttttgcta cttatttaat 4680
gataaaattt aatgacagtt taaaaaaaaa aaaaaaaaaa attatttgaa ggggtgggtg
4740 atttttgttt ttgtacagtt ttttttcaag cttcacattt gcgtgtatct
aattcagctg 4800 atgctcaagt ccaaggggta gtctgccttc ccaggctgcc
cccagggttt ctgcactggt 4860 cccctctttt cccttcagtc ttcttcactt ccctt
4895 <210> SEQ ID NO 14 <211> LENGTH: 1429 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
14 Met Ile Lys Cys Leu Ser Val Glu Val Gln Ala Lys Leu Arg Ser Gly
1 5 10 15 Leu Ala Ile Ser Ser Leu Gly Gln Cys Val Glu Glu Leu Ala
Leu Asn 20 25 30 Ser Ile Asp Ala Glu Ala Lys Cys Val Ala Val Arg
Val Asn Met Glu 35 40 45 Thr Phe Gln Val Gln Val Ile Asp Asn Gly
Phe Gly Met Gly Ser Asp 50 55 60 Asp Val Glu Lys Val Gly Asn Arg
Tyr Phe Thr Ser Lys Cys His Ser 65 70 75 80 Val Gln Asp Leu Glu Asn
Pro Arg Phe Tyr Gly Phe Arg Gly Glu Ala 85 90 95 Leu Ala Asn Ile
Ala Asp Met Ala Ser Ala Val Glu Ile Ser Ser Lys 100 105 110 Lys Asn
Arg Thr Met Lys Thr Phe Val Lys Leu Phe Gln Ser Gly Lys 115 120 125
Ala Leu Lys Ala Cys Glu Ala Asp Val Thr Arg Ala Ser Ala Gly Thr 130
135 140 Thr Val Thr Val Tyr Asn Leu Phe Tyr Gln Leu Pro Val Arg Arg
Lys 145 150 155 160 Cys Met Asp Pro Arg Leu Glu Phe Glu Lys Val Arg
Gln Arg Ile Glu 165 170 175 Ala Leu Ser Leu Met His Pro Ser Ile Ser
Phe Ser Leu Arg Asn Asp 180 185 190 Val Ser Gly Ser Met Val Leu Gln
Leu Pro Lys Thr Lys Asp Val Cys 195 200 205 Ser Arg Phe Cys Gln Ile
Tyr Gly Leu Gly Lys Ser Gln Lys Leu Arg 210 215 220 Glu Ile Ser Phe
Lys Tyr Lys Glu Phe Glu Leu Ser Gly Tyr Ile Ser 225 230 235 240 Ser
Glu Ala His Tyr Asn Lys Asn Met Gln Phe Leu Phe Val Asn Lys 245 250
255 Arg Leu Val Leu Arg Thr Lys Leu His Lys Leu Ile Asp Phe Leu Leu
260 265 270 Arg Lys Glu Ser Ile Ile Cys Lys Pro Lys Asn Gly Pro Thr
Ser Arg 275 280 285 Gln Met Asn Ser Ser Leu Arg His Arg Ser Thr Pro
Glu Leu Tyr Gly 290 295 300 Ile Tyr Val Ile Asn Val Gln Cys Gln Phe
Cys Glu Tyr Asp Val Cys 305 310 315 320 Met Glu Pro Ala Lys Thr Leu
Ile Glu Phe Gln Asn Trp Asp Thr Leu 325 330 335 Leu Phe Cys Ile Gln
Glu Gly Val Lys Met Phe Leu Lys Gln Glu Lys 340 345 350 Leu Phe Val
Glu Leu Ser Gly Glu Asp Ile Lys Glu Phe Ser Glu Asp 355 360 365 Asn
Gly Phe Ser Leu Phe Asp Ala Thr Leu Gln Lys Arg Val Thr Ser 370 375
380 Asp Glu Arg Ser Asn Phe Gln Glu Ala Cys Asn Asn Ile Leu Asp Ser
385 390 395 400 Tyr Glu Met Phe Asn Leu Gln Ser Lys Ala Val Lys Arg
Lys Thr Thr 405 410 415 Ala Glu Asn Val Asn Thr Gln Ser Ser Arg Asp
Ser Glu Ala Thr Arg 420 425 430 Lys Asn Thr Asn Asp Ala Phe Leu Tyr
Ile Tyr Glu Ser Gly Gly Pro 435 440 445 Gly His Ser Lys Met Thr Glu
Pro Ser Leu Gln Asn Lys Asp Ser Ser 450 455 460 Cys Ser Glu Ser Lys
Met Leu Glu Gln Glu Thr Ile Val Ala Ser Glu 465 470 475 480 Ala Gly
Glu Asn Glu Lys His Lys Lys Ser Phe Leu Glu Arg Ser Ser 485 490 495
Leu Glu Asn Pro Cys Gly Thr Ser Leu Glu Met Phe Leu Ser Pro Phe 500
505 510 Gln Thr Pro Cys His Phe Glu Glu Ser Gly Gln Asp Leu Glu Ile
Trp 515 520 525 Lys Glu Ser Thr Thr Val Asn Gly Met Ala Ala Asn Ile
Leu Lys Asn 530 535 540 Asn Arg Ile Gln Asn Gln Pro Lys Arg Phe Lys
Asp Ala Thr Glu Val 545 550 555 560 Gly Cys Gln Pro Leu Pro Phe Ala
Thr Thr Leu Trp Gly Val His Ser 565 570 575 Ala Gln Thr Glu Lys Glu
Lys Lys Lys Glu Ser Ser Asn Cys Gly Arg 580 585 590 Arg Asn Val Phe
Ser Tyr Gly Arg Val Lys Leu Cys Ser Thr Gly Phe 595 600 605 Ile Thr
His Val Val Gln Asn Glu Lys Thr Lys Ser Thr Glu Thr Glu 610 615 620
His Ser Phe Lys Asn Tyr Val Arg Pro Gly Pro Thr Arg Ala Gln Glu 625
630 635 640 Thr Phe Gly Asn Arg Thr Arg His Ser Val Glu Thr Pro Asp
Ile Lys 645 650 655 Asp Leu Ala Ser Thr Leu Ser Lys Glu Ser Gly Gln
Leu Pro Asn Lys 660 665 670 Lys Asn Cys Arg Thr Asn Ile Ser Tyr Gly
Leu Glu Asn Glu Pro Thr 675 680 685 Ala Thr Tyr Thr Met Phe Ser Ala
Phe Gln Glu Gly Ser Lys Lys Ser 690 695 700 Gln Thr Asp Cys Ile Leu
Ser Asp Thr Ser Pro Ser Phe Pro Trp Tyr 705 710 715 720 Arg His Val
Ser Asn Asp Ser Arg Lys Thr Asp Lys Leu Ile Gly Phe 725 730 735 Ser
Lys Pro Ile Val Arg Lys Lys Leu Ser Leu Ser Ser Gln Leu Gly 740 745
750 Ser Leu Glu Lys Phe Lys Arg Gln Tyr Gly Lys Val Glu Asn Pro Leu
755 760 765 Asp Thr Glu Val Glu Glu Ser Asn Gly Val Thr Thr Asn Leu
Ser Leu 770 775 780 Gln Val Glu Pro Asp Ile Leu Leu Lys Asp Lys Asn
Arg Leu Glu Asn 785 790 795 800 Ser Asp Val Cys Lys Ile Thr Thr Met
Glu His Ser Asp Ser Asp Ser 805 810 815 Ser Cys Gln Pro Ala Ser His
Ile Leu Asp Ser Glu Lys Phe Pro Phe 820 825 830 Ser Lys Asp Glu Asp
Cys Leu Glu Gln Gln Met Pro Ser Leu Arg Glu 835 840 845 Ser Pro Met
Thr Leu Lys Glu Leu Ser Leu Phe Asn Arg Lys Pro Leu 850 855 860 Asp
Leu Glu Lys Ser Ser Glu Ser Leu Ala Ser Lys Leu Ser Arg Leu 865 870
875 880 Lys Gly Ser Glu Arg Glu Thr Gln Thr Met Gly Met Met Ser Arg
Phe 885 890 895 Asn Glu Leu Pro Asn Ser Asp Ser Ser Arg Lys Asp Ser
Lys Leu Cys 900 905 910 Ser Val Leu Thr Gln Asp Phe Cys Met Leu Phe
Asn Asn Lys His Glu 915 920 925 Lys Thr Glu Asn Gly Val Ile Pro Thr
Ser Asp Ser Ala Thr Gln Asp 930 935 940 Asn Ser Phe Asn Lys Asn Ser
Lys Thr His Ser Asn Ser Asn Thr Thr 945 950 955 960 Glu Asn Cys Val
Ile Ser Glu Thr Pro Leu Val Leu Pro Tyr Asn Asn 965 970 975 Ser Lys
Val Thr Gly Lys Asp Ser Asp Val Leu Ile Arg Ala Ser Glu 980 985 990
Gln Gln Ile Gly Ser Leu Asp Ser Pro Ser Gly Met Leu Met Asn Pro 995
1000 1005 Val Glu Asp Ala Thr Gly Asp Gln Asn Gly Ile Cys Phe Gln
Ser 1010 1015 1020 Glu Glu Ser Lys Ala Arg Ala Cys Ser Glu Thr Glu
Glu Ser Asn 1025 1030 1035 Thr Cys Cys Ser Asp Trp Gln Arg His Phe
Asp Val Ala Leu Gly 1040 1045 1050 Arg Met Val Tyr Val Asn Lys Met
Thr Gly Leu Ser Thr Phe Ile 1055 1060 1065 Ala Pro Thr Glu Asp Ile
Gln Ala Ala Cys Thr Lys Asp Leu Thr 1070 1075 1080 Thr Val Ala Val
Asp Val Val Leu Glu Asn Gly Ser Gln Tyr Arg 1085 1090 1095 Cys Gln
Pro Phe Arg Ser Asp Leu Val Leu Pro Phe Leu Pro Arg 1100 1105 1110
Ala Arg Ala Glu Arg Thr Val Met Arg Gln Asp Asn Arg Asp Thr 1115
1120 1125 Val Asp Asp Thr Val Ser Ser Glu Ser Leu Gln Ser Leu Phe
Ser 1130 1135 1140 Glu Trp Asp Asn Pro Val Phe Ala Arg Tyr Pro Glu
Val Ala Val 1145 1150 1155 Asp Val Ser Ser Gly Gln Ala Glu Ser Leu
Ala Val Lys Ile His 1160 1165 1170 Asn Ile Leu Tyr Pro Tyr Arg Phe
Thr Lys Gly Met Ile His Ser 1175 1180 1185 Met Gln Val Leu Gln Gln
Val Asp Asn Lys Phe Ile Ala Cys Leu 1190 1195 1200 Met Ser Thr Lys
Thr Glu Glu Asn Gly Glu Ala Asp Ser Tyr Glu 1205 1210 1215 Lys Gln
Gln Ala Gln Gly Ser Gly Arg Lys Lys Leu Leu Ser Ser 1220 1225 1230
Thr Leu Ile Pro Pro Leu Glu Ile Thr Val Thr Glu Glu Gln Arg 1235
1240 1245 Arg Leu Leu Trp Cys Tyr His Lys Asn Leu Glu Asp Leu Gly
Leu 1250 1255 1260 Glu Phe Val Phe Pro Asp Thr Ser Asp Ser Leu Val
Leu Val Gly 1265 1270 1275 Lys Val Pro Leu Cys Phe Val Glu Arg Glu
Ala Asn Glu Leu Arg 1280 1285 1290 Arg Gly Arg Ser Thr Val Thr Lys
Ser Ile Val Glu Glu Phe Ile 1295 1300 1305 Arg Glu Gln Leu Glu Leu
Leu Gln Thr Thr Gly Gly Ile Gln Gly 1310 1315 1320 Thr Leu Pro Leu
Thr Val Gln Lys Val Leu Ala Ser Gln Ala Cys 1325 1330 1335 His Gly
Ala Ile Lys Phe Asn Asp Gly Leu Ser Leu Gln Glu Ser 1340 1345 1350
Cys Arg Leu Ile Glu Ala Leu Ser Ser Cys Gln Leu Pro Phe Gln 1355
1360 1365 Cys Ala His Gly Arg Pro Ser Met Leu Pro Leu Ala Asp Ile
Asp 1370 1375 1380 His Leu Glu Gln Glu Lys Gln Ile Lys Pro Asn Leu
Thr Lys Leu 1385 1390 1395 Arg Lys Met Ala Gln Ala Trp Arg Leu Phe
Gly Lys Ala Glu Cys 1400 1405 1410 Asp Thr Arg Gln Ser Leu Gln Gln
Ser Met Pro Pro Cys Glu Pro 1415 1420 1425 Pro <210> SEQ ID
NO 15 <211> LENGTH: 3145 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 15 ggcgggaaac
agcttagtgg gtgtggggtc gcgcattttc ttcaaccagg aggtgaggag 60
gtttcgacat ggcggtgcag ccgaaggaga cgctgcagtt ggagagcgcg gccgaggtcg
120 gcttcgtgcg cttctttcag ggcatgccgg agaagccgac caccacagtg
cgccttttcg 180 accggggcga cttctatacg gcgcacggcg aggacgcgct
gctggccgcc cgggaggtgt 240 tcaagaccca gggggtgatc aagtacatgg
ggccggcagg agcaaagaat ctgcagagtg 300 ttgtgcttag taaaatgaat
tttgaatctt ttgtaaaaga tcttcttctg gttcgtcagt 360 atagagttga
agtttataag aatagagctg gaaataaggc atccaaggag aatgattggt 420
atttggcata taaggcttct cctggcaatc tctctcagtt tgaagacatt ctctttggta
480 acaatgatat gtcagcttcc attggtgttg tgggtgttaa aatgtccgca
gttgatggcc 540 agagacaggt tggagttggg tatgtggatt ccatacagag
gaaactagga ctgtgtgaat 600 tccctgataa tgatcagttc tccaatcttg
aggctctcct catccagatt ggaccaaagg 660 aatgtgtttt acccggagga
gagactgctg gagacatggg gaaactgaga cagataattc 720 aaagaggagg
aattctgatc acagaaagaa aaaaagctga cttttccaca aaagacattt 780
atcaggacct caaccggttg ttgaaaggca aaaagggaga gcagatgaat agtgctgtat
840 tgccagaaat ggagaatcag gttgcagttt catcactgtc tgcggtaatc
aagtttttag 900 aactcttatc agatgattcc aactttggac agtttgaact
gactactttt gacttcagcc 960 agtatatgaa attggatatt gcagcagtca
gagcccttaa cctttttcag ggttctgttg 1020 aagataccac tggctctcag
tctctggctg ccttgctgaa taagtgtaaa acccctcaag 1080 gacaaagact
tgttaaccag tggattaagc agcctctcat ggataagaac agaatagagg 1140
agagattgaa tttagtggaa gcttttgtag aagatgcaga attgaggcag actttacaag
1200 aagatttact tcgtcgattc ccagatctta accgacttgc caagaagttt
caaagacaag 1260 cagcaaactt acaagattgt taccgactct atcagggtat
aaatcaacta cctaatgtta 1320 tacaggctct ggaaaaacat gaaggaaaac
accagaaatt attgttggca gtttttgtga 1380 ctcctcttac tgatcttcgt
tctgacttct ccaagtttca ggaaatgata gaaacaactt 1440 tagatatgga
tcaggtggaa aaccatgaat tccttgtaaa accttcattt gatcctaatc 1500
tcagtgaatt aagagaaata atgaatgact tggaaaagaa gatgcagtca acattaataa
1560 gtgcagccag agatcttggc ttggaccctg gcaaacagat taaactggat
tccagtgcac 1620 agtttggata ttactttcgt gtaacctgta aggaagaaaa
agtccttcgt aacaataaaa 1680 actttagtac tgtagatatc cagaagaatg
gtgttaaatt taccaacagc aaattgactt 1740 ctttaaatga agagtatacc
aaaaataaaa cagaatatga agaagcccag gatgccattg 1800 ttaaagaaat
tgtcaatatt tcttcaggct atgtagaacc aatgcagaca ctcaatgatg 1860
tgttagctca gctagatgct gttgtcagct ttgctcacgt gtcaaatgga gcacctgttc
1920 catatgtacg accagccatt ttggagaaag gacaaggaag aattatatta
aaagcatcca 1980 ggcatgcttg tgttgaagtt caagatgaaa ttgcatttat
tcctaatgac gtatactttg 2040 aaaaagataa acagatgttc cacatcatta
ctggccccaa tatgggaggt aaatcaacat 2100 atattcgaca aactggggtg
atagtactca tggcccaaat tgggtgtttt gtgccatgtg 2160 agtcagcaga
agtgtccatt gtggactgca tcttagcccg agtaggggct ggtgacagtc 2220
aattgaaagg agtctccacg ttcatggctg aaatgttgga aactgcttct atcctcaggt
2280 ctgcaaccaa agattcatta ataatcatag atgaattggg aagaggaact
tctacctacg 2340 atggatttgg gttagcatgg gctatatcag aatacattgc
aacaaagatt ggtgcttttt 2400 gcatgtttgc aacccatttt catgaactta
ctgccttggc caatcagata ccaactgtta 2460 ataatctaca tgtcacagca
ctcaccactg aagagacctt aactatgctt tatcaggtga 2520 agaaaggtgt
ctgtgatcaa agttttggga ttcatgttgc agagcttgct aatttcccta 2580
agcatgtaat agagtgtgct aaacagaaag ccctggaact tgaggagttt cagtatattg
2640 gagaatcgca aggatatgat atcatggaac cagcagcaaa gaagtgctat
ctggaaagag 2700 agcaaggtga aaaaattatt caggagttcc tgtccaaggt
gaaacaaatg ccctttactg 2760 aaatgtcaga agaaaacatc acaataaagt
taaaacagct aaaagctgaa gtaatagcaa 2820 agaataatag ctttgtaaat
gaaatcattt cacgaataaa agttactacg tgaaaaatcc 2880 cagtaatgga
atgaaggtaa tattgataag ctattgtctg taatagtttt atattgtttt 2940
atattaaccc tttttccata gtgttaactg tcagtgccca tgggctatca acttaataag
3000 atatttagta atattttact ttgaggacat tttcaaagat ttttattttg
aaaaatgaga 3060 gctgtaactg aggactgttt gcaattgaca taggcaataa
taagtgatgt gctgaatttt 3120 ataaataaaa tcatgtagtt tgtgg 3145
<210> SEQ ID NO 16 <211> LENGTH: 934 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 16 Met
Ala Val Gln Pro Lys Glu Thr Leu Gln Leu Glu Ser Ala Ala Glu 1 5 10
15 Val Gly Phe Val Arg Phe Phe Gln Gly Met Pro Glu Lys Pro Thr Thr
20 25 30 Thr Val Arg Leu Phe Asp Arg Gly Asp Phe Tyr Thr Ala His
Gly Glu 35 40 45 Asp Ala Leu Leu Ala Ala Arg Glu Val Phe Lys Thr
Gln Gly Val Ile 50 55 60 Lys Tyr Met Gly Pro Ala Gly Ala Lys Asn
Leu Gln Ser Val Val Leu 65 70 75 80 Ser Lys Met Asn Phe Glu Ser Phe
Val Lys Asp Leu Leu Leu Val Arg 85 90 95 Gln Tyr Arg Val Glu Val
Tyr Lys Asn Arg Ala Gly Asn Lys Ala Ser 100 105 110 Lys Glu Asn Asp
Trp Tyr Leu Ala Tyr Lys Ala Ser Pro Gly Asn Leu 115 120 125 Ser Gln
Phe Glu Asp Ile Leu Phe Gly Asn Asn Asp Met Ser Ala Ser 130 135 140
Ile Gly Val Val Gly Val Lys Met Ser Ala Val Asp Gly Gln Arg Gln 145
150 155 160 Val Gly Val Gly Tyr Val Asp Ser Ile Gln Arg Lys Leu Gly
Leu Cys 165 170 175 Glu Phe Pro Asp Asn Asp Gln Phe Ser Asn Leu Glu
Ala Leu Leu Ile 180 185 190 Gln Ile Gly Pro Lys Glu Cys Val Leu Pro
Gly Gly Glu Thr Ala Gly 195 200 205 Asp Met Gly Lys Leu Arg Gln Ile
Ile Gln Arg Gly Gly Ile Leu Ile 210 215 220 Thr Glu Arg Lys Lys Ala
Asp Phe Ser Thr Lys Asp Ile Tyr Gln Asp 225 230 235 240 Leu Asn Arg
Leu Leu Lys Gly Lys Lys Gly Glu Gln Met Asn Ser Ala 245 250 255 Val
Leu Pro Glu Met Glu Asn Gln Val Ala Val Ser Ser Leu Ser Ala 260 265
270 Val Ile Lys Phe Leu Glu Leu Leu Ser Asp Asp Ser Asn Phe Gly Gln
275 280 285 Phe Glu Leu Thr Thr Phe Asp Phe Ser Gln Tyr Met Lys Leu
Asp Ile 290 295 300 Ala Ala Val Arg Ala Leu Asn Leu Phe Gln Gly Ser
Val Glu Asp Thr 305 310 315 320 Thr Gly Ser Gln Ser Leu Ala Ala Leu
Leu Asn Lys Cys Lys Thr Pro 325 330 335 Gln Gly Gln Arg Leu Val Asn
Gln Trp Ile Lys Gln Pro Leu Met Asp 340 345 350 Lys Asn Arg Ile Glu
Glu Arg Leu Asn Leu Val Glu Ala Phe Val Glu 355 360 365 Asp Ala Glu
Leu Arg Gln Thr Leu Gln Glu Asp Leu Leu Arg Arg Phe 370 375 380 Pro
Asp Leu Asn Arg Leu Ala Lys Lys Phe Gln Arg Gln Ala Ala Asn 385 390
395 400 Leu Gln Asp Cys Tyr Arg Leu Tyr Gln Gly Ile Asn Gln Leu Pro
Asn 405 410 415 Val Ile Gln Ala Leu Glu Lys His Glu Gly Lys His Gln
Lys Leu Leu 420 425 430 Leu Ala Val Phe Val Thr Pro Leu Thr Asp Leu
Arg Ser Asp Phe Ser 435 440 445 Lys Phe Gln Glu Met Ile Glu Thr Thr
Leu Asp Met Asp Gln Val Glu 450 455 460 Asn His Glu Phe Leu Val Lys
Pro Ser Phe Asp Pro Asn Leu Ser Glu 465 470 475 480 Leu Arg Glu Ile
Met Asn Asp Leu Glu Lys Lys Met Gln Ser Thr Leu 485 490 495 Ile Ser
Ala Ala Arg Asp Leu Gly Leu Asp Pro Gly Lys Gln Ile Lys 500 505 510
Leu Asp Ser Ser Ala Gln Phe Gly Tyr Tyr Phe Arg Val Thr Cys Lys 515
520 525 Glu Glu Lys Val Leu Arg Asn Asn Lys Asn Phe Ser Thr Val Asp
Ile 530 535 540 Gln Lys Asn Gly Val Lys Phe Thr Asn Ser Lys Leu Thr
Ser Leu Asn 545 550 555 560 Glu Glu Tyr Thr Lys Asn Lys Thr Glu Tyr
Glu Glu Ala Gln Asp Ala 565 570 575 Ile Val Lys Glu Ile Val Asn Ile
Ser Ser Gly Tyr Val Glu Pro Met 580 585 590 Gln Thr Leu Asn Asp Val
Leu Ala Gln Leu Asp Ala Val Val Ser Phe 595 600 605 Ala His Val Ser
Asn Gly Ala Pro Val Pro Tyr Val Arg Pro Ala Ile 610 615 620 Leu Glu
Lys Gly Gln Gly Arg Ile Ile Leu Lys Ala Ser Arg His Ala 625 630 635
640 Cys Val Glu Val Gln Asp Glu Ile Ala Phe Ile Pro Asn Asp Val Tyr
645 650 655 Phe Glu Lys Asp Lys Gln Met Phe His Ile Ile Thr Gly Pro
Asn Met 660 665 670 Gly Gly Lys Ser Thr Tyr Ile Arg Gln Thr Gly Val
Ile Val Leu Met 675 680 685 Ala Gln Ile Gly Cys Phe Val Pro Cys Glu
Ser Ala Glu Val Ser Ile 690 695 700 Val Asp Cys Ile Leu Ala Arg Val
Gly Ala Gly Asp Ser Gln Leu Lys 705 710 715 720 Gly Val Ser Thr Phe
Met Ala Glu Met Leu Glu Thr Ala Ser Ile Leu 725 730 735 Arg Ser Ala
Thr Lys Asp Ser Leu Ile Ile Ile Asp Glu Leu Gly Arg 740 745 750 Gly
Thr Ser Thr Tyr Asp Gly Phe Gly Leu Ala Trp Ala Ile Ser Glu 755 760
765 Tyr Ile Ala Thr Lys Ile Gly Ala Phe Cys Met Phe Ala Thr His Phe
770 775 780 His Glu Leu Thr Ala Leu Ala Asn Gln Ile Pro Thr Val Asn
Asn Leu 785 790 795 800 His Val Thr Ala Leu Thr Thr Glu Glu Thr Leu
Thr Met Leu Tyr Gln 805 810 815 Val Lys Lys Gly Val Cys Asp Gln Ser
Phe Gly Ile His Val Ala Glu 820 825 830 Leu Ala Asn Phe Pro Lys His
Val Ile Glu Cys Ala Lys Gln Lys Ala 835 840 845 Leu Glu Leu Glu Glu
Phe Gln Tyr Ile Gly Glu Ser Gln Gly Tyr Asp 850 855 860 Ile Met Glu
Pro Ala Ala Lys Lys Cys Tyr Leu Glu Arg Glu Gln Gly 865 870 875 880
Glu Lys Ile Ile Gln Glu Phe Leu Ser Lys Val Lys Gln Met Pro Phe 885
890 895 Thr Glu Met Ser Glu Glu Asn Ile Thr Ile Lys Leu Lys Gln Leu
Lys 900 905 910 Ala Glu Val Ile Ala Lys Asn Asn Ser Phe Val Asn Glu
Ile Ile Ser 915 920 925 Arg Ile Lys Val Thr Thr 930 <210> SEQ
ID NO 17 <211> LENGTH: 4374 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 17 gggcacgagc
cctgccatgt ctcgccggaa gcctgcgtcg ggcggcctcg ctgcctccag 60
ctcagcccct gcgaggcaag cggttttgag ccgattcttc cagtctacgg gaagcctgaa
120 atccacctcc tcctccacag gtgcagccga ccaggtggac cctggcgctg
cagcggccgc 180 agcgccccca gcgcccgcct tcccgcccca gctgccgccg
cacgtagcta cagaaattga 240 cagaagaaag aagagaccat tggaaaatga
tgggcctgtt aaaaagaaag taaagaaagt 300 ccaacaaaag gaaggaggaa
gtgatctggg aatgtctggc aactctgagc caaagaaatg 360 tctgaggacc
aggaatgttt caaagtctct ggaaaaattg aaagaattct gctgcgattc 420
tgcccttcct caaagtagag tccagacaga atctctgcag gagagatttg cagttctgcc
480 aaaatgtact gattttgatg atatcagtct tctacacgca aagaatgcag
tttcttctga 540 agattcgaaa cgtcaaatta atcaaaagga cacaacactt
tttgatctca gtcagtttgg 600 atcatcaaat acaagtcatg aaaatttaca
gaaaactgct tccaaatcag ctaacaaacg 660 gtccaaaagc atctatacgc
cgctagaatt acaatacata gaaatgaagc agcagcacaa 720 agatgcagtt
ttgtgtgtgg aatgtggata taagtataga ttctttgggg aagatgcaga 780
gattgcagcc cgagagctca atatttattg ccatttagat cacaacttta tgacagcaag
840 tatacctact cacagactgt ttgttcatgt acgccgcctg gtggcaaaag
gatataaggt 900 gggagttgtg aagcaaactg aaactgcagc attaaaggcc
attggagaca acagaagttc 960 actcttttcc cggaaattga ctgcccttta
tacaaaatct acacttattg gagaagatgt 1020 gaatccccta atcaagctgg
atgatgctgt aaatgttgat gagataatga ctgatacttc 1080 taccagctat
cttctgtgca tctctgaaaa taaggaaaat gttagggaca aaaaaaaggg 1140
caacattttt attggcattg tgggagtgca gcctgccaca ggcgaggttg tgtttgatag
1200 tttccaggac tctgcttctc gttcagagct agaaacccgg atgtcaagcc
tgcagccagt 1260 agagctgctg cttccttcgg ccttgtccga gcaaacagag
gcgctcatcc acagagccac 1320 atctgttagt gtgcaggatg acagaattcg
agtcgaaagg atggataaca tttattttga 1380 atacagccat gctttccagg
cagttacaga gttttatgca aaagatacag ttgacatcaa 1440 aggttctcaa
attatttctg gcattgttaa cttagagaag cctgtgattt gctctttggc 1500
tgccatcata aaatacctca aagaattcaa cttggaaaag atgctctcca aacctgagaa
1560 ttttaaacag ctatcaagta aaatggaatt tatgacaatt aatggaacaa
cattaaggaa 1620 tctggaaatc ctacagaatc agactgatat gaaaaccaaa
ggaagtttgc tgtgggtttt 1680 agaccacact aaaacttcat ttgggagacg
gaagttaaag aagtgggtga cccagccact 1740 ccttaaatta agggaaataa
atgcccggct tgatgctgta tcggaagttc tccattcaga 1800 atctagtgtg
tttggtcaga tagaaaatca tctacgtaaa ttgcccgaca tagagagggg 1860
actctgtagc atttatcaca aaaaatgttc tacccaagag ttcttcttga ttgtcaaaac
1920 tttatatcac ctaaagtcag aatttcaagc aataatacct gctgttaatt
cccacattca 1980 gtcagacttg ctccggaccg ttattttaga aattcctgaa
ctcctcagtc cagtggagca 2040 ttacttaaag atactcaatg aacaagctgc
caaagttggg gataaaactg aattatttaa 2100 agacctttct gacttccctt
taataaaaaa gaggaaggat gaaattcaag gtgttattga 2160 cgagatccga
atgcatttgc aagaaatacg aaaaatacta aaaaatcctt ctgcacaata 2220
tgtgacagta tcaggacagg agtttatgat agaaataaag aactctgctg tatcttgtat
2280 accaactgat tgggtaaagg ttggaagcac aaaagctgtg agccgctttc
actctccttt 2340 tattgtagaa aattacagac atctgaatca gctccgggag
cagctagtcc ttgactgcag 2400 tgctgaatgg cttgattttc tagagaaatt
cagtgaacat tatcactcct tgtgtaaagc 2460 agtgcatcac ctagcaactg
ttgactgcat tttctccctg gccaaggtcg ctaagcaagg 2520 agattactgc
agaccaactg tacaagaaga aagaaaaatt gtaataaaaa atggaaggca 2580
ccctgtgatt gatgtgttgc tgggagaaca ggatcaatat gtcccaaata atacagattt
2640 atcagaggac tcagagagag taatgataat taccggacca aacatgggtg
gaaagagctc 2700 ctacataaaa caagttgcat tgattaccat catggctcag
attggctcct atgttcctgc 2760 agaagaagcg acaattggga ttgtggatgg
cattttcaca aggatgggtg ctgcagacaa 2820 tatatataaa ggacggagta
catttatgga agaactgact gacacagcag aaataatcag 2880 aaaagcaaca
tcacagtcct tggttatctt ggatgaacta ggaagaggga cgagcactca 2940
tgatggaatt gccattgcct atgctacact tgagtatttc atcagagatg tgaaatcctt
3000 aaccctgttt gtcacccatt atccgccagt ttgtgaacta gaaaaaaatt
actcacacca 3060 ggtggggaat taccacatgg gattcttggt cagtgaggat
gaaagcaaac tggatccagg 3120 cgcagcagaa caagtccctg attttgtcac
cttcctttac caaataacta gaggaattgc 3180 agcaaggagt tatggattaa
atgtggctaa actagcagat gttcctggag aaattttgaa 3240 gaaagcagct
cacaagtcaa aagagctgga aggattaata aatacgaaaa gaaagagact 3300
caagtatttt gcaaagttat ggacgatgca taatgcacaa gacctgcaga agtggacaga
3360 ggagttcaac atggaagaaa cacagacttc tcttcttcat taaaatgaag
actacatttg 3420 tgaacaaaaa atggagaatt aaaaatacca actgtacaaa
ataactctcc agtaacagcc 3480 tatctttgtg tgacatgtga gcataaaatt
atgaccatgg tatattccta ttggaaacag 3540 agaggttttt ctgaagacag
tctttttcaa gtttctgtct tcctaacttt tctacgtata 3600 aacactcttg
aatagacttc cactttgtaa ttagaaaatt ttatggacag taagtccagt 3660
aaagccttaa gtggcagaat ataattccca agcttttgga gggtgatata aaaatttact
3720 tgatattttt atttgtttca gttcagataa ttggcaactg ggtgaatctg
gcaggaatct 3780 atccattgaa ctaaaataat tttattatgc aaccagttta
tccaccaaga acataagaat 3840 tttttataag tagaaagaat tggccaggca
tggtggctca tgcctgtaat cccagcactt 3900 tgggaggcca aggtaggcag
atcacctgag gtcaggagtt caagaccagc ctggccaaca 3960 tggcaaaacc
ccatctttac taaaaatata aagtacatct ctactaaaaa tacgaaaaaa 4020
ttagctgggc atggtggcgc acacctgtag tcccagctac tccggaggct gaggcaggag
4080 aatctcttga acctgggagg cggaggttgc aatgagccga gatcacgtca
ctgcactcca 4140 gcttgggcaa cagagcaaga ctccatctca aaaaagaaaa
aagaaaagaa atagaattat 4200 caagctttta aaaactagag cacagaagga
ataaggtcat gaaatttaaa aggttaaata 4260 ttgtcatagg attaagcagt
ttaaagattg ttggatgaaa ttatttgtca ttcattcaag 4320 taataaatat
ttaatgaata cttgctataa aaaaaaaaaa aaaaaaaaaa aaaa 4374 <210>
SEQ ID NO 18 <211> LENGTH: 1128 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 18 Met Ser
Arg Arg Lys Pro Ala Ser Gly Gly Leu Ala Ala Ser Ser Ser 1 5 10 15
Ala Pro Ala Arg Gln Ala Val Leu Ser Arg Phe Phe Gln Ser Thr Gly 20
25 30 Ser Leu Lys Ser Thr Ser Ser Ser Thr Gly Ala Ala Asp Gln Val
Asp 35 40 45 Pro Gly Ala Ala Ala Ala Ala Ala Pro Pro Ala Pro Ala
Phe Pro Pro 50 55 60 Gln Leu Pro Pro His Val Ala Thr Glu Ile Asp
Arg Arg Lys Lys Arg 65 70 75 80 Pro Leu Glu Asn Asp Gly Pro Val Lys
Lys Lys Val Lys Lys Val Gln 85 90 95 Gln Lys Glu Gly Gly Ser Asp
Leu Gly Met Ser Gly Asn Ser Glu Pro 100 105 110 Lys Lys Cys Leu Arg
Thr Arg Asn Val Ser Lys Ser Leu Glu Lys Leu 115 120 125 Lys Glu Phe
Cys Cys Asp Ser Ala Leu Pro Gln Ser Arg Val Gln Thr 130 135 140 Glu
Ser Leu Gln Glu Arg Phe Ala Val Leu Pro Lys Cys Thr Asp Phe 145 150
155 160 Asp Asp Ile Ser Leu Leu His Ala Lys Asn Ala Val Ser Ser Glu
Asp 165 170 175 Ser Lys Arg Gln Ile Asn Gln Lys Asp Thr Thr Leu Phe
Asp Leu Ser 180 185 190 Gln Phe Gly Ser Ser Asn Thr Ser His Glu Asn
Leu Gln Lys Thr Ala 195 200 205 Ser Lys Ser Ala Asn Lys Arg Ser Lys
Ser Ile Tyr Thr Pro Leu Glu 210 215 220 Leu Gln Tyr Ile Glu Met Lys
Gln Gln His Lys Asp Ala Val Leu Cys 225 230 235 240 Val Glu Cys Gly
Tyr Lys Tyr Arg Phe Phe Gly Glu Asp Ala Glu Ile 245 250 255 Ala Ala
Arg Glu Leu Asn Ile Tyr Cys His Leu Asp His Asn Phe Met 260 265 270
Thr Ala Ser Ile Pro Thr His Arg Leu Phe Val His Val Arg Arg Leu 275
280 285 Val Ala Lys Gly Tyr Lys Val Gly Val Val Lys Gln Thr Glu Thr
Ala 290 295 300 Ala Leu Lys Ala Ile Gly Asp Asn Arg Ser Ser Leu Phe
Ser Arg Lys 305 310 315 320 Leu Thr Ala Leu Tyr Thr Lys Ser Thr Leu
Ile Gly Glu Asp Val Asn 325 330 335 Pro Leu Ile Lys Leu Asp Asp Ala
Val Asn Val Asp Glu Ile Met Thr 340 345 350 Asp Thr Ser Thr Ser Tyr
Leu Leu Cys Ile Ser Glu Asn Lys Glu Asn 355 360 365 Val Arg Asp Lys
Lys Lys Gly Asn Ile Phe Ile Gly Ile Val Gly Val 370 375 380 Gln Pro
Ala Thr Gly Glu Val Val Phe Asp Ser Phe Gln Asp Ser Ala 385 390 395
400 Ser Arg Ser Glu Leu Glu Thr Arg Met Ser Ser Leu Gln Pro Val Glu
405 410 415 Leu Leu Leu Pro Ser Ala Leu Ser Glu Gln Thr Glu Ala Leu
Ile His 420 425 430 Arg Ala Thr Ser Val Ser Val Gln Asp Asp Arg Ile
Arg Val Glu Arg 435 440 445 Met Asp Asn Ile Tyr Phe Glu Tyr Ser His
Ala Phe Gln Ala Val Thr 450 455 460 Glu Phe Tyr Ala Lys Asp Thr Val
Asp Ile Lys Gly Ser Gln Ile Ile 465 470 475 480 Ser Gly Ile Val Asn
Leu Glu Lys Pro Val Ile Cys Ser Leu Ala Ala 485 490 495 Ile Ile Lys
Tyr Leu Lys Glu Phe Asn Leu Glu Lys Met Leu Ser Lys 500 505 510 Pro
Glu Asn Phe Lys Gln Leu Ser Ser Lys Met Glu Phe Met Thr Ile 515 520
525 Asn Gly Thr Thr Leu Arg Asn Leu Glu Ile Leu Gln Asn Gln Thr Asp
530 535 540 Met Lys Thr Lys Gly Ser Leu Leu Trp Val Leu Asp His Thr
Lys Thr 545 550 555 560 Ser Phe Gly Arg Arg Lys Leu Lys Lys Trp Val
Thr Gln Pro Leu Leu 565 570 575 Lys Leu Arg Glu Ile Asn Ala Arg Leu
Asp Ala Val Ser Glu Val Leu 580 585 590 His Ser Glu Ser Ser Val Phe
Gly Gln Ile Glu Asn His Leu Arg Lys 595 600 605 Leu Pro Asp Ile Glu
Arg Gly Leu Cys Ser Ile Tyr His Lys Lys Cys 610 615 620 Ser Thr Gln
Glu Phe Phe Leu Ile Val Lys Thr Leu Tyr His Leu Lys 625 630 635 640
Ser Glu Phe Gln Ala Ile Ile Pro Ala Val Asn Ser His Ile Gln Ser 645
650 655 Asp Leu Leu Arg Thr Val Ile Leu Glu Ile Pro Glu Leu Leu Ser
Pro 660 665 670 Val Glu His Tyr Leu Lys Ile Leu Asn Glu Gln Ala Ala
Lys Val Gly 675 680 685 Asp Lys Thr Glu Leu Phe Lys Asp Leu Ser Asp
Phe Pro Leu Ile Lys 690 695 700 Lys Arg Lys Asp Glu Ile Gln Gly Val
Ile Asp Glu Ile Arg Met His 705 710 715 720 Leu Gln Glu Ile Arg Lys
Ile Leu Lys Asn Pro Ser Ala Gln Tyr Val 725 730 735 Thr Val Ser Gly
Gln Glu Phe Met Ile Glu Ile Lys Asn Ser Ala Val 740 745 750 Ser Cys
Ile Pro Thr Asp Trp Val Lys Val Gly Ser Thr Lys Ala Val 755 760 765
Ser Arg Phe His Ser Pro Phe Ile Val Glu Asn Tyr Arg His Leu Asn 770
775 780 Gln Leu Arg Glu Gln Leu Val Leu Asp Cys Ser Ala Glu Trp Leu
Asp 785 790 795 800 Phe Leu Glu Lys Phe Ser Glu His Tyr His Ser Leu
Cys Lys Ala Val 805 810 815 His His Leu Ala Thr Val Asp Cys Ile Phe
Ser Leu Ala Lys Val Ala 820 825 830 Lys Gln Gly Asp Tyr Cys Arg Pro
Thr Val Gln Glu Glu Arg Lys Ile 835 840 845 Val Ile Lys Asn Gly Arg
His Pro Val Ile Asp Val Leu Leu Gly Glu 850 855 860 Gln Asp Gln Tyr
Val Pro Asn Asn Thr Asp Leu Ser Glu Asp Ser Glu 865 870 875 880 Arg
Val Met Ile Ile Thr Gly Pro Asn Met Gly Gly Lys Ser Ser Tyr 885 890
895 Ile Lys Gln Val Ala Leu Ile Thr Ile Met Ala Gln Ile Gly Ser Tyr
900 905 910 Val Pro Ala Glu Glu Ala Thr Ile Gly Ile Val Asp Gly Ile
Phe Thr 915 920 925 Arg Met Gly Ala Ala Asp Asn Ile Tyr Lys Gly Arg
Ser Thr Phe Met 930 935 940 Glu Glu Leu Thr Asp Thr Ala Glu Ile Ile
Arg Lys Ala Thr Ser Gln 945 950 955 960 Ser Leu Val Ile Leu Asp Glu
Leu Gly Arg Gly Thr Ser Thr His Asp 965 970 975 Gly Ile Ala Ile Ala
Tyr Ala Thr Leu Glu Tyr Phe Ile Arg Asp Val 980 985 990 Lys Ser Leu
Thr Leu Phe Val Thr His Tyr Pro Pro Val Cys Glu Leu 995 1000 1005
Glu Lys Asn Tyr Ser His Gln Val Gly Asn Tyr His Met Gly Phe 1010
1015 1020 Leu Val Ser Glu Asp Glu Ser Lys Leu Asp Pro Gly Ala Ala
Glu 1025 1030 1035 Gln Val Pro Asp Phe Val Thr Phe Leu Tyr Gln Ile
Thr Arg Gly 1040 1045 1050 Ile Ala Ala Arg Ser Tyr Gly Leu Asn Val
Ala Lys Leu Ala Asp 1055 1060 1065 Val Pro Gly Glu Ile Leu Lys Lys
Ala Ala His Lys Ser Lys Glu 1070 1075 1080 Leu Glu Gly Leu Ile Asn
Thr Lys Arg Lys Arg Leu Lys Tyr Phe 1085 1090 1095 Ala Lys Leu Trp
Thr Met His Asn Ala Gln Asp Leu Gln Lys Trp 1100 1105 1110 Thr Glu
Glu Phe Asn Met Glu Glu Thr Gln Thr Ser Leu Leu His 1115 1120 1125
<210> SEQ ID NO 19 <211> LENGTH: 3095 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 19
cagaaacctc atacttctcg ggtcagggaa ggtttgggag gatgctgagg cctgagatct
60 catcaacctc gccttctgcc ccggcggttt cccccgtcgt cggagaaacc
cgctcacctc 120 agggtccccg ctacaatttc ggactccagg agactccaca
gagccgccct tcggtccagg 180 tggtctctgc atccacctgt cctggcacgt
caggagctgc gggcgaccgg agcagcagca 240 gcagcagcct tccctgcccc
gcgccaaact cccggccagc tcaaggttca tactttggaa 300 acaaaagagc
ttatgcagaa aacacagttg catcaaattt tacttttggt gcaagctcat 360
cttctgcacg agatactaat tatcctcaaa cacttaaaac tccattgtct actggaaatc
420 ctcagagatc aggttataag agctggacac cacaagtggg atattcagct
tcatcctcat 480 ctgcgatttc tgcacactcc ccatcagtta ttgtagctgt
tgtagaaggg agaggacttg 540 ccagaggtga aataggaatg gcaagtattg
atttaaaaaa cccccaaatt atactatccc 600 agtttgcaga caacacaaca
tatgcaaagg tgatcactaa acttaaaatt ttatcacctt 660 tggaaataat
aatgtcaaat actgcttgtg ctgtggggaa ttccaccaag ttgttcactc 720
tgatcacaga aaatttcaag aatgttaatt tcactactat ccaaaggaaa tacttcaatg
780 aaacaaaagg attagagtac attgaacagt tatgcatagc agaattcagc
actgtcctaa 840 tggaggttca gtccaagtat tactgccttg cagctgttgc
agctttgtta aaatatgttg 900 aatttattca aaattcagtt tatgcaccaa
aatcactgaa gatttgtttc cagggtagtg 960 aacagacagc catgatagat
tcatcatcag cccaaaacct tgaattgtta attaataatc 1020 aagactatag
gaataatcac actctctttg gtgttctaaa ttatactaag actcctggag 1080
ggagtagacg acttcgttct aatatattag agcctctagt tgatattgaa accattaaca
1140 tgcgcttaga ttgtgttcaa gaactacttc aagatgagga actatttttt
ggacttcaat 1200 cagttatatc aagatttctt gatacagagc agcttctttc
tgttttagtc caaattccag 1260 agcaagacac ggtcaatgct gctgaatcaa
agataacaaa tttaatatac ttaaaacata 1320 ccttggaact tgtggatcct
ttaaagattg ctatgaagaa ctgtaacaca cctttattaa 1380 gagcttacta
tggttccttg gaagacaaga ggtttggaat catacttgaa aagattaaaa 1440
cagtaattaa tgatgatgca agatacatga aaggatgcct aaacatgagg actcagaagt
1500 gctatgcagt gaggtctaac ataaatgaat ttcttgacat agcaagaaga
acatacacag 1560 agattgtaga tgacatagca ggaatgatat cacaacttgg
agaaaaatat agtctacctt 1620 taaggacaag tcttagctct gttcgaggat
ttttcatcca gatgactaca gattgtatag 1680 ccctacctag tgatcaactt
ccttcagaat ttattaagat ttctaaagtg aaaaattctt 1740 acagctttac
atcagcagat ttaattaaaa tgaatgaaag atgccaagaa tctttgagag 1800
aaatctatca catgacttat atgatagtgt gcaaactgct tagtgagatt tatgaacata
1860 ttcattgctt atataaacta tctgacactg tgtcaatgct ggatatgcta
ctgtcatttg 1920 ctcatgcctg cactctttct gactatgttc gaccagaatt
tactgatact ttagcaatca 1980 aacagggatg gcatcctatt cttgaaaaaa
tatctgcgga aaaacctatt gccaacaata 2040 cctatgttac agaagggagt
aattttttga tcataactgg accaaacatg agtggaaaat 2100 ccacatattt
aaaacagatt gctctttgtc agattatggc ccagattgga tcatatgttc 2160
cagcagaata ttcttccttt agaattgcta aacagatttt tacaagaatt agtactgatg
2220 atgatatcga aacaaattca tcaacattta tgaaagaaat gaaagagata
gcatatattc 2280 tacataatgc taatgacaaa tcgctcatat taattgatga
acttggcaga ggtactaata 2340 cggaagaagg tattggcatt tgttatgctg
tttgtgaata tctactgagc ttaaaggcat 2400 ttacactgtt tgctacacat
ttcctggaac tatgccatat tgatgccctg tatcctaatg 2460 tagaaaacat
gcattttgaa gttcaacatg taaagaatac ctcaagaaat aaagaagcaa 2520
ttttgtatac ctacaaactt tctaagggac tcacagaaga gaaaaattat ggattaaaag
2580 ctgcagaggt gtcatcactt ccaccatcaa ttgtcttgga tgccaaggaa
atcacaactc 2640 aaattacgag acaaattttg caaaaccaaa ggagtacccc
tgagatggaa agacagagag 2700 ctgtgtacca tctagccact aggcttgttc
aaactgctcg aaactctcaa ttggatccag 2760 acagtttacg aatatattta
agtaacctca agaagaagta caaagaagat tttcccagga 2820 ccgaacaagt
tccagaaaag actgaagaat aatcacaatt ctaatgtaat aatatatctt 2880
aattcaagga acctagaatt tatttttctc cttagagata aggaaaataa catttgccaa
2940 atttcatatt ttaattgaaa attacattat attaacatca caattgtcat
ctatatattc 3000 tatatgaaaa atatttatta taacttaaca aatgagaact
acttaaagga atggttttta 3060 tgttaggaga aaatacaata caccacaaaa aaaaa
3095 <210> SEQ ID NO 20 <211> LENGTH: 936 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
20 Met Leu Arg Pro Glu Ile Ser Ser Thr Ser Pro Ser Ala Pro Ala Val
1 5 10 15 Ser Pro Val Val Gly Glu Thr Arg Ser Pro Gln Gly Pro Arg
Tyr Asn 20 25 30 Phe Gly Leu Gln Glu Thr Pro Gln Ser Arg Pro Ser
Val Gln Val Val 35 40 45 Ser Ala Ser Thr Cys Pro Gly Thr Ser Gly
Ala Ala Gly Asp Arg Ser 50 55 60 Ser Ser Ser Ser Ser Leu Pro Cys
Pro Ala Pro Asn Ser Arg Pro Ala 65 70 75 80 Gln Gly Ser Tyr Phe Gly
Asn Lys Arg Ala Tyr Ala Glu Asn Thr Val 85 90 95 Ala Ser Asn Phe
Thr Phe Gly Ala Ser Ser Ser Ser Ala Arg Asp Thr 100 105 110 Asn Tyr
Pro Gln Thr Leu Lys Thr Pro Leu Ser Thr Gly Asn Pro Gln 115 120 125
Arg Ser Gly Tyr Lys Ser Trp Thr Pro Gln Val Gly Tyr Ser Ala Ser 130
135 140 Ser Ser Ser Ala Ile Ser Ala His Ser Pro Ser Val Ile Val Ala
Val 145 150 155 160 Val Glu Gly Arg Gly Leu Ala Arg Gly Glu Ile Gly
Met Ala Ser Ile 165 170 175 Asp Leu Lys Asn Pro Gln Ile Ile Leu Ser
Gln Phe Ala Asp Asn Thr 180 185 190 Thr Tyr Ala Lys Val Ile Thr Lys
Leu Lys Ile Leu Ser Pro Leu Glu 195 200 205 Ile Ile Met Ser Asn Thr
Ala Cys Ala Val Gly Asn Ser Thr Lys Leu 210 215 220 Phe Thr Leu Ile
Thr Glu Asn Phe Lys Asn Val Asn Phe Thr Thr Ile 225 230 235 240 Gln
Arg Lys Tyr Phe Asn Glu Thr Lys Gly Leu Glu Tyr Ile Glu Gln 245 250
255 Leu Cys Ile Ala Glu Phe Ser Thr Val Leu Met Glu Val Gln Ser Lys
260 265 270 Tyr Tyr Cys Leu Ala Ala Val Ala Ala Leu Leu Lys Tyr Val
Glu Phe 275 280 285 Ile Gln Asn Ser Val Tyr Ala Pro Lys Ser Leu Lys
Ile Cys Phe Gln 290 295 300 Gly Ser Glu Gln Thr Ala Met Ile Asp Ser
Ser Ser Ala Gln Asn Leu 305 310 315 320 Glu Leu Leu Ile Asn Asn Gln
Asp Tyr Arg Asn Asn His Thr Leu Phe 325 330 335 Gly Val Leu Asn Tyr
Thr Lys Thr Pro Gly Gly Ser Arg Arg Leu Arg 340 345 350 Ser Asn Ile
Leu Glu Pro Leu Val Asp Ile Glu Thr Ile Asn Met Arg 355 360 365 Leu
Asp Cys Val Gln Glu Leu Leu Gln Asp Glu Glu Leu Phe Phe Gly 370 375
380 Leu Gln Ser Val Ile Ser Arg Phe Leu Asp Thr Glu Gln Leu Leu Ser
385 390 395 400 Val Leu Val Gln Ile Pro Glu Gln Asp Thr Val Asn Ala
Ala Glu Ser 405 410 415 Lys Ile Thr Asn Leu Ile Tyr Leu Lys His Thr
Leu Glu Leu Val Asp 420 425 430 Pro Leu Lys Ile Ala Met Lys Asn Cys
Asn Thr Pro Leu Leu Arg Ala 435 440 445 Tyr Tyr Gly Ser Leu Glu Asp
Lys Arg Phe Gly Ile Ile Leu Glu Lys 450 455 460 Ile Lys Thr Val Ile
Asn Asp Asp Ala Arg Tyr Met Lys Gly Cys Leu 465 470 475 480 Asn Met
Arg Thr Gln Lys Cys Tyr Ala Val Arg Ser Asn Ile Asn Glu 485 490 495
Phe Leu Asp Ile Ala Arg Arg Thr Tyr Thr Glu Ile Val Asp Asp Ile 500
505 510 Ala Gly Met Ile Ser Gln Leu Gly Glu Lys Tyr Ser Leu Pro Leu
Arg 515 520 525 Thr Ser Leu Ser Ser Val Arg Gly Phe Phe Ile Gln Met
Thr Thr Asp 530 535 540 Cys Ile Ala Leu Pro Ser Asp Gln Leu Pro Ser
Glu Phe Ile Lys Ile 545 550 555 560 Ser Lys Val Lys Asn Ser Tyr Ser
Phe Thr Ser Ala Asp Leu Ile Lys 565 570 575 Met Asn Glu Arg Cys Gln
Glu Ser Leu Arg Glu Ile Tyr His Met Thr 580 585 590 Tyr Met Ile Val
Cys Lys Leu Leu Ser Glu Ile Tyr Glu His Ile His 595 600 605 Cys Leu
Tyr Lys Leu Ser Asp Thr Val Ser Met Leu Asp Met Leu Leu 610 615 620
Ser Phe Ala His Ala Cys Thr Leu Ser Asp Tyr Val Arg Pro Glu Phe 625
630 635 640 Thr Asp Thr Leu Ala Ile Lys Gln Gly Trp His Pro Ile Leu
Glu Lys 645 650 655 Ile Ser Ala Glu Lys Pro Ile Ala Asn Asn Thr Tyr
Val Thr Glu Gly 660 665 670 Ser Asn Phe Leu Ile Ile Thr Gly Pro Asn
Met Ser Gly Lys Ser Thr 675 680 685 Tyr Leu Lys Gln Ile Ala Leu Cys
Gln Ile Met Ala Gln Ile Gly Ser 690 695 700 Tyr Val Pro Ala Glu Tyr
Ser Ser Phe Arg Ile Ala Lys Gln Ile Phe 705 710 715 720 Thr Arg Ile
Ser Thr Asp Asp Asp Ile Glu Thr Asn Ser Ser Thr Phe 725 730 735 Met
Lys Glu Met Lys Glu Ile Ala Tyr Ile Leu His Asn Ala Asn Asp 740 745
750 Lys Ser Leu Ile Leu Ile Asp Glu Leu Gly Arg Gly Thr Asn Thr Glu
755 760 765 Glu Gly Ile Gly Ile Cys Tyr Ala Val Cys Glu Tyr Leu Leu
Ser Leu 770 775 780 Lys Ala Phe Thr Leu Phe Ala Thr His Phe Leu Glu
Leu Cys His Ile 785 790 795 800 Asp Ala Leu Tyr Pro Asn Val Glu Asn
Met His Phe Glu Val Gln His 805 810 815 Val Lys Asn Thr Ser Arg Asn
Lys Glu Ala Ile Leu Tyr Thr Tyr Lys 820 825 830 Leu Ser Lys Gly Leu
Thr Glu Glu Lys Asn Tyr Gly Leu Lys Ala Ala 835 840 845 Glu Val Ser
Ser Leu Pro Pro Ser Ile Val Leu Asp Ala Lys Glu Ile 850 855 860 Thr
Thr Gln Ile Thr Arg Gln Ile Leu Gln Asn Gln Arg Ser Thr Pro 865 870
875 880 Glu Met Glu Arg Gln Arg Ala Val Tyr His Leu Ala Thr Arg Leu
Val 885 890 895 Gln Thr Ala Arg Asn Ser Gln Leu Asp Pro Asp Ser Leu
Arg Ile Tyr 900 905 910 Leu Ser Asn Leu Lys Lys Lys Tyr Lys Glu Asp
Phe Pro Arg Thr Glu 915 920 925 Gln Val Pro Glu Lys Thr Glu Glu 930
935 <210> SEQ ID NO 21 <211> LENGTH: 2726 <212>
TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE:
21 gcggtcggtc agcggggcgt tctcccacct gtagcgactc agagcctcca
agctcatggc 60 ctccttagga gcgaacccaa ggaggacacc gcagggaccg
agacctgggg cggcctcctc 120 cggcttcccc agcccggccc cagtgccggg
ccccagggag gccgaggagg aggaagtcga 180 ggaggaggag gagctggccg
agatccatct gtgtgtgctg tggaattcag gatacttggg 240 cattgcctac
tatgatacta gtgactccac tatccacttc atgccagatg ccccagacca 300
cgagagcctc aagcttctcc agagagttct ggatgagatc aatccccagt ctgttgttac
360 gagtgccaaa caggatgaga atatgactcg atttctggga aagcttgcct
cccaggagca 420 cagagagcct aaaagacctg aaatcatatt tttgccaagt
gtggattttg gtctggagat 480 aagcaaacaa cgcctccttt ctggaaacta
ctccttcatc ccagacgcca tgactgccac 540 tgagaaaatc ctcttcctct
cttccattat tccctttgac tgcctcctca cagttcgagc 600 acttggaggg
ctgctgaagt tcctgggtcg aagaagaatc ggggttgaac tggaagacta 660
taatgtcagc gtccccatcc tgggctttaa gaaatttatg ttgactcatc tggtgaacat
720 agatcaagac acttacagtg ttctacagat ttttaagagt gagtctcacc
cctcagtgta 780 caaagtggcc agtggactga aggaggggct cagcctcttt
ggaatcctca acagatgcca 840 ctgtaagtgg ggagagaagc tgctcaggct
atggttcaca cgtccgactc atgacctggg 900 ggagctcagt tctcgtctgg
acgtcattca gttttttctg ctgccccaga atctggacat 960 ggctcagatg
ctgcatcggc tcctgggtca catcaagaac gtgcctctga ttctgaaacg 1020
catgaagttg tcccacacca aggtcagcga ctggcaggtt ctctacaaga ctgtgtacag
1080 tgccctgggc ctgagggatg cctgccgctc cctgccgcag tccatccagc
tctttcggga 1140 cattgcccaa gagttctctg atgacctgca ccatatcgcc
agcctcattg ggaaagtagt 1200 ggactttgag ggcagccttg ctgaaaatcg
cttcacagtc ctccccaaca tagatcctga 1260 aattgatgag aaaaagcgaa
gactgatggg acttcccagt ttccttactg aggttgcccg 1320 caaggagctg
gagaatctgg actcccgtat tccttcatgc agtgtcatct acatccctct 1380
gattggcttc cttctttcta ttccccgcct gccttccatg gtagaggcca gtgactttga
1440 gattaatgga ctggacttca tgtttctctc agaggagaag ctgcactatc
gtagtgcccg 1500 aaccaaggag ctggatgcat tgctggggga cctgcactgc
gagatccggg accaggagac 1560 gctgctgatg taccagctac agtgccaggt
gctggcacga gcagctgtct taacccgagt 1620 attggacctt gcctcccgcc
tggacgtcct gctggctctt gccagtgctg cccgggacta 1680 tggctactca
aggccgcgtt actccccaca agtccttggg gtacgaatcc agaatggcag 1740
acatcctctg atggaactct gtgcccgaac ctttgtgccc aactccacag aatgtggtgg
1800 ggacaaaggg agggtcaaag tcatcactgg acccaactca tcagggaaga
gcatatacct 1860 caaacaggta ggcttgatca cattcatggc cctggtaggc
agctttgtgc cagcagagga 1920 ggccgaaatt ggggcagtag acgccatctt
cacacgaatt catagctgcg aatccatctc 1980 ccttggcctc tccaccttca
tgatcgacct caaccagcag gtggcgaaag cagtgaacaa 2040 tgccactgca
cagtcgctgg tccttattga tgaatttgga aagggaacca acacggtgga 2100
tgggctcgcg cttctggccg ctgtgctccg acactggctg gcacgtggac ccacatgccc
2160 ccacatcttt gtggccacca actttctgag ccttgttcag ctacaactgc
tgccacaagg 2220 gcccctggtg cagtatttga ccatggagac ctgtgaggat
ggcaacgatc ttgtcttctt 2280 ctatcaggtt tgcgaaggtg ttgcgaaggc
cagccatgcc tcccacacag ctgcccaggc 2340 tgggcttcct gacaagcttg
tggctcgtgg caaggaggtc tcagacttga tccgcagtgg 2400 aaaacccatc
aagcctgtca aggatttgct aaagaagaac caaatggaaa attgccagac 2460
attagtggat aagtttatga aactggattt ggaagatcct aacctggact tgaacgtttt
2520 catgagccag gaagtgctgc ctgctgccac cagcatcctc tgagagtcct
tccagtgtcc 2580 tccccagcct cctgagactc cggtgggctg ccatgccctc
tttgtttcct tatctccctc 2640 agacgcagag tttttagttt ctctagaaat
tttgtttcat attaggaata aagtttattt 2700 tgaagaaaaa aaaaaaaaaa aaaaaa
2726 <210> SEQ ID NO 22 <211> LENGTH: 835 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
22 Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg
1 5 10 15 Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val
Pro Gly 20 25 30 Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu
Glu Glu Leu Ala 35 40 45 Glu Ile His Leu Cys Val Leu Trp Asn Ser
Gly Tyr Leu Gly Ile Ala 50 55 60 Tyr Tyr Asp Thr Ser Asp Ser Thr
Ile His Phe Met Pro Asp Ala Pro 65 70 75 80 Asp His Glu Ser Leu Lys
Leu Leu Gln Arg Val Leu Asp Glu Ile Asn 85 90 95 Pro Gln Ser Val
Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg 100 105 110 Phe Leu
Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro 115 120 125
Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 130
135 140 Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met
Thr 145 150 155 160 Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile
Pro Phe Asp Cys 165 170 175 Leu Leu Thr Val Arg Ala Leu Gly Gly Leu
Leu Lys Phe Leu Gly Arg 180 185 190 Arg Arg Ile Gly Val Glu Leu Glu
Asp Tyr Asn Val Ser Val Pro Ile 195 200 205 Leu Gly Phe Lys Lys Phe
Met Leu Thr His Leu Val Asn Ile Asp Gln 210 215 220 Asp Thr Tyr Ser
Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro Ser 225 230 235 240 Val
Tyr Lys Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe Gly 245 250
255 Ile Leu Asn Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg Leu
260 265 270 Trp Phe Thr Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser
Arg Leu 275 280 285 Asp Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu
Asp Met Ala Gln 290 295 300 Met Leu His Arg Leu Leu Gly His Ile Lys
Asn Val Pro Leu Ile Leu 305 310 315 320 Lys Arg Met Lys Leu Ser His
Thr Lys Val Ser Asp Trp Gln Val Leu 325 330 335 Tyr Lys Thr Val Tyr
Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg Ser 340 345 350 Leu Pro Gln
Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe Ser 355 360 365 Asp
Asp Leu His His Ile Ala Ser Leu Ile Gly Lys Val Val Asp Phe 370 375
380 Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn Ile Asp
385 390 395 400 Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu
Pro Ser Phe 405 410 415 Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn
Leu Asp Ser Arg Ile 420 425 430 Pro Ser Cys Ser Val Ile Tyr Ile Pro
Leu Ile Gly Phe Leu Leu Ser 435 440 445 Ile Pro Arg Leu Pro Ser Met
Val Glu Ala Ser Asp Phe Glu Ile Asn 450 455 460 Gly Leu Asp Phe Met
Phe Leu Ser Glu Glu Lys Leu His Tyr Arg Ser 465 470 475 480 Ala Arg
Thr Lys Glu Leu Asp Ala Leu Leu Gly Asp Leu His Cys Glu 485 490 495
Ile Arg Asp Gln Glu Thr Leu Leu Met Tyr Gln Leu Gln Cys Gln Val 500
505 510 Leu Ala Arg Ala Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser
Arg 515 520 525 Leu Asp Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp
Tyr Gly Tyr 530 535 540 Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly
Val Arg Ile Gln Asn 545 550 555 560 Gly Arg His Pro Leu Met Glu Leu
Cys Ala Arg Thr Phe Val Pro Asn 565 570 575 Ser Thr Glu Cys Gly Gly
Asp Lys Gly Arg Val Lys Val Ile Thr Gly 580 585 590 Pro Asn Ser Ser
Gly Lys Ser Ile Tyr Leu Lys Gln Val Gly Leu Ile 595 600 605 Thr Phe
Met Ala Leu Val Gly Ser Phe Val Pro Ala Glu Glu Ala Glu 610 615 620
Ile Gly Ala Val Asp Ala Ile Phe Thr Arg Ile His Ser Cys Glu Ser 625
630 635 640 Ile Ser Leu Gly Leu Ser Thr Phe Met Ile Asp Leu Asn Gln
Gln Val 645 650 655 Ala Lys Ala Val Asn Asn Ala Thr Ala Gln Ser Leu
Val Leu Ile Asp 660 665 670 Glu Phe Gly Lys Gly Thr Asn Thr Val Asp
Gly Leu Ala Leu Leu Ala 675 680 685 Ala Val Leu Arg His Trp Leu Ala
Arg Gly Pro Thr Cys Pro His Ile 690 695 700 Phe Val Ala Thr Asn Phe
Leu Ser Leu Val Gln Leu Gln Leu Leu Pro 705 710 715 720 Gln Gly Pro
Leu Val Gln Tyr Leu Thr Met Glu Thr Cys Glu Asp Gly 725 730 735 Asn
Asp Leu Val Phe Phe Tyr Gln Val Cys Glu Gly Val Ala Lys Ala 740 745
750 Ser His Ala Ser His Thr Ala Ala Gln Ala Gly Leu Pro Asp Lys Leu
755 760 765 Val Ala Arg Gly Lys Glu Val Ser Asp Leu Ile Arg Ser Gly
Lys Pro 770 775 780 Ile Lys Pro Val Lys Asp Leu Leu Lys Lys Asn Gln
Met Glu Asn Cys 785 790 795 800 Gln Thr Leu Val Asp Lys Phe Met Lys
Leu Asp Leu Glu Asp Pro Asn 805 810 815 Leu Asp Leu Asn Val Phe Met
Ser Gln Glu Val Leu Pro Ala Ala Thr 820 825 830 Ser Ile Leu 835
<210> SEQ ID NO 23 <211> LENGTH: 4264 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 23
atttcccgcc agcaggagcc gcgcggtaga tgcggtgctt ttaggagctc cgtccgacag
60 aacggttggg ccttgccggc tgtcggtatg tcgcgacaga gcaccctgta
cagcttcttc 120 cccaagtctc cggcgctgag tgatgccaac aaggcctcgg
ccagggcctc acgcgaaggc 180 ggccgtgccg ccgctgcccc cggggcctct
ccttccccag gcggggatgc ggcctggagc 240 gaggctgggc ctgggcccag
gcccttggcg cgatccgcgt caccgcccaa ggcgaagaac 300 ctcaacggag
ggctgcggag atcggtagcg cctgctgccc ccaccagttg tgacttctca 360
ccaggagatt tggtttgggc caagatggag ggttacccct ggtggccttg tctggtttac
420 aaccacccct ttgatggaac attcatccgc gagaaaggga aatcagtccg
tgttcatgta 480 cagttttttg atgacagccc aacaaggggc tgggttagca
aaaggctttt aaagccatat 540 acaggttcaa aatcaaagga agcccagaag
ggaggtcatt tttacagtgc aaagcctgaa 600 atactgagag caatgcaacg
tgcagatgaa gccttaaata aagacaagat taagaggctt 660 gaattggcag
tttgtgatga gccctcagag ccagaagagg aagaagagat ggaggtaggc 720
acaacttacg taacagataa gagtgaagaa gataatgaaa ttgagagtga agaggaagta
780 cagcctaaga cacaaggatc taggcgaagt agccgccaaa taaaaaaacg
aagggtcata 840 tcagattctg agagtgacat tggtggctct gatgtggaat
ttaagccaga cactaaggag 900 gaaggaagca gtgatgaaat aagcagtgga
gtgggggata gtgagagtga aggcctgaac 960 agccctgtca aagttgctcg
aaagcggaag agaatggtga ctggaaatgg ctctcttaaa 1020 aggaaaagct
ctaggaagga aacgccctca gccaccaaac aagcaactag catttcatca 1080
gaaaccaaga atactttgag agctttctct gcccctcaaa attctgaatc ccaagcccac
1140 gttagtggag gtggtgatga cagtagtcgc cctactgttt ggtatcatga
aactttagaa 1200 tggcttaagg aggaaaagag aagagatgag cacaggagga
ggcctgatca ccccgatttt 1260 gatgcatcta cactctatgt gcctgaggat
ttcctcaatt cttgtactcc tgggatgagg 1320 aagtggtggc agattaagtc
tcagaacttt gatcttgtca tctgttacaa ggtggggaaa 1380 ttttatgagc
tgtaccacat ggatgctctt attggagtca gtgaactggg gctggtattc 1440
atgaaaggca actgggccca ttctggcttt cctgaaattg catttggccg ttattcagat
1500 tccctggtgc agaagggcta taaagtagca cgagtggaac agactgagac
tccagaaatg 1560 atggaggcac gatgtagaaa gatggcacat atatccaagt
atgatagagt ggtgaggagg 1620 gagatctgta ggatcattac caagggtaca
cagacttaca gtgtgctgga aggtgatccc 1680 tctgagaact acagtaagta
tcttcttagc ctcaaagaaa aagaggaaga ttcttctggc 1740 catactcgtg
catatggtgt gtgctttgtt gatacttcac tgggaaagtt tttcataggt 1800
cagttttcag atgatcgcca ttgttcgaga tttaggactc tagtggcaca ctatccccca
1860 gtacaagttt tatttgaaaa aggaaatctc tcaaaggaaa ctaaaacaat
tctaaagagt 1920 tcattgtcct gttctcttca ggaaggtctg atacccggct
cccagttttg ggatgcatcc 1980 aaaactttga gaactctcct tgaggaagaa
tattttaggg aaaagctaag tgatggcatt 2040 ggggtgatgt taccccaggt
gcttaaaggt atgacttcag agtctgattc cattgggttg 2100 acaccaggag
agaaaagtga attggccctc tctgctctag gtggttgtgt cttctacctc 2160
aaaaaatgcc ttattgatca ggagctttta tcaatggcta attttgaaga atatattccc
2220 ttggattctg acacagtcag cactacaaga tctggtgcta tcttcaccaa
agcctatcaa 2280 cgaatggtgc tagatgcagt gacattaaac aacttggaga
tttttctgaa tggaacaaat 2340 ggttctactg aaggaaccct actagagagg
gttgatactt gccatactcc ttttggtaag 2400 cggctcctaa agcaatggct
ttgtgcccca ctctgtaacc attatgctat taatgatcgt 2460 ctagatgcca
tagaagacct catggttgtg cctgacaaaa tctccgaagt tgtagagctt 2520
ctaaagaagc ttccagatct tgagaggcta ctcagtaaaa ttcataatgt tgggtctccc
2580 ctgaagagtc agaaccaccc agacagcagg gctataatgt atgaagaaac
tacatacagc 2640 aagaagaaga ttattgattt tctttctgct ctggaaggat
tcaaagtaat gtgtaaaatt 2700 atagggatca tggaagaagt tgctgatggt
tttaagtcta aaatccttaa gcaggtcatc 2760 tctctgcaga caaaaaatcc
tgaaggtcgt tttcctgatt tgactgtaga attgaaccga 2820 tgggatacag
cctttgacca tgaaaaggct cgaaagactg gacttattac tcccaaagca 2880
ggctttgact ctgattatga ccaagctctt gctgacataa gagaaaatga acagagcctc
2940 ctggaatacc tagagaaaca gcgcaacaga attggctgta ggaccatagt
ctattggggg 3000 attggtagga accgttacca gctggaaatt cctgagaatt
tcaccactcg caatttgcca 3060 gaagaatacg agttgaaatc taccaagaag
ggctgtaaac gatactggac caaaactatt 3120 gaaaagaagt tggctaatct
cataaatgct gaagaacgga gggatgtatc attgaaggac 3180 tgcatgcggc
gactgttcta taactttgat aaaaattaca aggactggca gtctgctgta 3240
gagtgtatcg cagtgttgga tgttttactg tgcctggcta actatagtcg agggggtgat
3300 ggtcctatgt gtcgcccagt aattctgttg ccggaagata cccccccctt
cttagagctt 3360 aaaggatcac gccatccttg cattacgaag actttttttg
gagatgattt tattcctaat 3420 gacattctaa taggctgtga ggaagaggag
caggaaaatg gcaaagccta ttgtgtgctt 3480 gttactggac caaatatggg
gggcaagtct acgcttatga gacaggctgg cttattagct 3540 gtaatggccc
agatgggttg ttacgtccct gctgaagtgt gcaggctcac accaattgat 3600
agagtgttta ctagacttgg tgcctcagac agaataatgt caggtgaaag tacatttttt
3660 gttgaattaa gtgaaactgc cagcatactc atgcatgcaa cagcacattc
tctggtgctt 3720 gtggatgaat taggaagagg tactgcaaca tttgatggga
cggcaatagc aaatgcagtt 3780 gttaaagaac ttgctgagac tataaaatgt
cgtacattat tttcaactca ctaccattca 3840 ttagtagaag attattctca
aaatgttgct gtgcgcctag gacatatggc atgcatggta 3900 gaaaatgaat
gtgaagaccc cagccaggag actattacgt tcctctataa attcattaag 3960
ggagcttgtc ctaaaagcta tggctttaat gcagcaaggc ttgctaatct cccagaggaa
4020 gttattcaaa agggacatag aaaagcaaga gaatttgaga agatgaatca
gtcactacga 4080 ttatttcggg aagtttgcct ggctagtgaa aggtcaactg
tagatgctga agctgtccat 4140 aaattgctga ctttgattaa ggaattatag
actgactaca ttggaagctt tgagttgact 4200 tctgaccaaa ggtggtaaat
tcagacaaca ttatgatcta ataaacttta ttttttaaaa 4260 atga 4264
<210> SEQ ID NO 24 <211> LENGTH: 1360 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 24 Met
Ser Arg Gln Ser Thr Leu Tyr Ser Phe Phe Pro Lys Ser Pro Ala 1 5 10
15 Leu Ser Asp Ala Asn Lys Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly
20 25 30 Arg Ala Ala Ala Ala Pro Gly Ala Ser Pro Ser Pro Gly Gly
Asp Ala 35 40 45 Ala Trp Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu
Ala Arg Ser Ala 50 55 60 Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly
Gly Leu Arg Arg Ser Val 65 70 75 80 Ala Pro Ala Ala Pro Thr Ser Cys
Asp Phe Ser Pro Gly Asp Leu Val 85 90 95 Trp Ala Lys Met Glu Gly
Tyr Pro Trp Trp Pro Cys Leu Val Tyr Asn 100 105 110 His Pro Phe Asp
Gly Thr Phe Ile Arg Glu Lys Gly Lys Ser Val Arg 115 120 125 Val His
Val Gln Phe Phe Asp Asp Ser Pro Thr Arg Gly Trp Val Ser 130 135 140
Lys Arg Leu Leu Lys Pro Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln 145
150 155 160 Lys Gly Gly His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg
Ala Met 165 170 175 Gln Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile
Lys Arg Leu Glu 180 185 190 Leu Ala Val Cys Asp Glu Pro Ser Glu Pro
Glu Glu Glu Glu Glu Met 195 200 205 Glu Val Gly Thr Thr Tyr Val Thr
Asp Lys Ser Glu Glu Asp Asn Glu 210 215 220 Ile Glu Ser Glu Glu Glu
Val Gln Pro Lys Thr Gln Gly Ser Arg Arg 225 230 235 240 Ser Ser Arg
Gln Ile Lys Lys Arg Arg Val Ile Ser Asp Ser Glu Ser 245 250 255 Asp
Ile Gly Gly Ser Asp Val Glu Phe Lys Pro Asp Thr Lys Glu Glu 260 265
270 Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu Ser Glu
275 280 285 Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg Lys Arg
Met Val 290 295 300 Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser Ser Arg
Lys Glu Thr Pro 305 310 315 320 Ser Ala Thr Lys Gln Ala Thr Ser Ile
Ser Ser Glu Thr Lys Asn Thr 325 330 335 Leu Arg Ala Phe Ser Ala Pro
Gln Asn Ser Glu Ser Gln Ala His Val 340 345 350 Ser Gly Gly Gly Asp
Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu 355 360 365 Thr Leu Glu
Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg 370 375 380 Arg
Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu 385 390
395 400 Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp Trp Gln
Ile 405 410 415 Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr Lys Val
Gly Lys Phe 420 425 430 Tyr Glu Leu Tyr His Met Asp Ala Leu Ile Gly
Val Ser Glu Leu Gly 435 440 445 Leu Val Phe Met Lys Gly Asn Trp Ala
His Ser Gly Phe Pro Glu Ile 450 455 460 Ala Phe Gly Arg Tyr Ser Asp
Ser Leu Val Gln Lys Gly Tyr Lys Val 465 470 475 480 Ala Arg Val Glu
Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys 485 490 495 Arg Lys
Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu 500 505 510
Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu 515
520 525 Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser Leu Lys
Glu 530 535 540 Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala Tyr Gly
Val Cys Phe 545 550 555 560 Val Asp Thr Ser Leu Gly Lys Phe Phe Ile
Gly Gln Phe Ser Asp Asp 565 570 575 Arg His Cys Ser Arg Phe Arg Thr
Leu Val Ala His Tyr Pro Pro Val 580 585 590 Gln Val Leu Phe Glu Lys
Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile 595 600 605 Leu Lys Ser Ser
Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly 610 615 620 Ser Gln
Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu 625 630 635
640 Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met Leu Pro
645 650 655 Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser Ile Gly
Leu Thr 660 665 670 Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser Ala Leu
Gly Gly Cys Val 675 680 685 Phe Tyr Leu Lys Lys Cys Leu Ile Asp Gln
Glu Leu Leu Ser Met Ala 690 695 700 Asn Phe Glu Glu Tyr Ile Pro Leu
Asp Ser Asp Thr Val Ser Thr Thr 705 710 715 720 Arg Ser Gly Ala Ile
Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp 725 730 735 Ala Val Thr
Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly 740 745 750 Ser
Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro 755 760
765 Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu Cys Asn
770 775 780 His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu Asp Leu
Met Val 785 790 795 800 Val Pro Asp Lys Ile Ser Glu Val Val Glu Leu
Leu Lys Lys Leu Pro 805 810 815 Asp Leu Glu Arg Leu Leu Ser Lys Ile
His Asn Val Gly Ser Pro Leu 820 825 830 Lys Ser Gln Asn His Pro Asp
Ser Arg Ala Ile Met Tyr Glu Glu Thr 835 840 845 Thr Tyr Ser Lys Lys
Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly 850 855 860 Phe Lys Val
Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp 865 870 875 880
Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr Lys 885
890 895 Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu Asn Arg
Trp 900 905 910 Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys Thr Gly
Leu Ile Thr 915 920 925 Pro Lys Ala Gly Phe Asp Ser Asp Tyr Asp Gln
Ala Leu Ala Asp Ile 930 935 940 Arg Glu Asn Glu Gln Ser Leu Leu Glu
Tyr Leu Glu Lys Gln Arg Asn 945 950 955 960 Arg Ile Gly Cys Arg Thr
Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg 965 970 975 Tyr Gln Leu Glu
Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu 980 985 990 Glu Tyr
Glu Leu Lys Ser Thr Lys Lys Gly Cys Lys Arg Tyr Trp Thr 995 1000
1005 Lys Thr Ile Glu Lys Lys Leu Ala Asn Leu Ile Asn Ala Glu Glu
1010 1015 1020 Arg Arg Asp Val Ser Leu Lys Asp Cys Met Arg Arg Leu
Phe Tyr 1025 1030 1035 Asn Phe Asp Lys Asn Tyr Lys Asp Trp Gln Ser
Ala Val Glu Cys 1040 1045 1050 Ile Ala Val Leu Asp Val Leu Leu Cys
Leu Ala Asn Tyr Ser Arg 1055 1060 1065 Gly Gly Asp Gly Pro Met Cys
Arg Pro Val Ile Leu Leu Pro Glu 1070 1075 1080 Asp Thr Pro Pro Phe
Leu Glu Leu Lys Gly Ser Arg His Pro Cys 1085 1090 1095 Ile Thr Lys
Thr Phe Phe Gly Asp Asp Phe Ile Pro Asn Asp Ile 1100 1105 1110 Leu
Ile Gly Cys Glu Glu Glu Glu Gln Glu Asn Gly Lys Ala Tyr 1115 1120
1125 Cys Val Leu Val Thr Gly Pro Asn Met Gly Gly Lys Ser Thr Leu
1130 1135 1140 Met Arg Gln Ala Gly Leu Leu Ala Val Met Ala Gln Met
Gly Cys 1145 1150 1155 Tyr Val Pro Ala Glu Val Cys Arg Leu Thr Pro
Ile Asp Arg Val 1160 1165 1170 Phe Thr Arg Leu Gly Ala Ser Asp Arg
Ile Met Ser Gly Glu Ser 1175 1180 1185 Thr Phe Phe Val Glu Leu Ser
Glu Thr Ala Ser Ile Leu Met His 1190 1195 1200 Ala Thr Ala His Ser
Leu Val Leu Val Asp Glu Leu Gly Arg Gly 1205 1210 1215 Thr Ala Thr
Phe Asp Gly Thr Ala Ile Ala Asn Ala Val Val Lys 1220 1225 1230 Glu
Leu Ala Glu Thr Ile Lys Cys Arg Thr Leu Phe Ser Thr His 1235 1240
1245 Tyr His Ser Leu Val Glu Asp Tyr Ser Gln Asn Val Ala Val Arg
1250 1255 1260 Leu Gly His Met Ala Cys Met Val Glu Asn Glu Cys Glu
Asp Pro 1265 1270 1275 Ser Gln Glu Thr Ile Thr Phe Leu Tyr Lys Phe
Ile Lys Gly Ala 1280 1285 1290 Cys Pro Lys Ser Tyr Gly Phe Asn Ala
Ala Arg Leu Ala Asn Leu 1295 1300 1305 Pro Glu Glu Val Ile Gln Lys
Gly His Arg Lys Ala Arg Glu Phe 1310 1315 1320 Glu Lys Met Asn Gln
Ser Leu Arg Leu Phe Arg Glu Val Cys Leu 1325 1330 1335 Ala Ser Glu
Arg Ser Thr Val Asp Ala Glu Ala Val His Lys Leu 1340 1345 1350 Leu
Thr Leu Ile Lys Glu Leu 1355 1360 <210> SEQ ID NO 25
<211> LENGTH: 1445 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 25 tttttttttt
tgatgttctc cagtgcctca gtggcagcag aactggccct gtatcaggcc 60
gctaccgcca ctccatgacc aacctccctg catacccccc cccccagcac ccctcccaca
120 ggaccgcttc tgtgtttggg acccaccagg cctttgcacc atacaacaaa
ccctcactct 180 ccggggcccg gtctgcgccc aggctgaaca ccacgaacgc
ctgggacgca gctcctcctt 240 ccctggggag ccagcccctc taccgctcca
gcctctccca cctgggaccg cagcacctgc 300 ccccaggatc ctccacctcc
ggtgcagtca gtgcctccct ccccagcggt ccctcaagca 360 gcccaggcga
gcgtccctgc cactgtgccc atgcagatgc caagccagca gagtcagcag 420
gcgctcgctg gagcgacccg aagccagagc agagcagagc aggtcataaa actacacgga
480 agagctgaaa gtgcccccag atgaggactg catcatctgc atggagaagc
tgtccgcagc 540 gtctggatac agcgatgtga ctgacagcaa ggcaatgggg
cccctggctg tgggctgcct 600 caccaagtgc agccacgcct tccacctgct
gtgcctcctg gccatgtact gcaacggcaa 660 taagggccct gagcacccca
atcccggaaa gccgttcact gccagagggt ttcccgccag 720 tgctaccttc
cagacaacgc cagggccgca agcctccagg ggcttccaga acccggagac 780
actggctgac attccggcct ccccacagct gctgaccgat ggccactaca tgacgctgcc
840 cgtgtctccg gaccagctgc cctgtgacga ccccatggcg ggcagcggag
gcgcccccgt 900 gctgcgggtg ggccatgacc acggctgcca ccagcagcca
cgtatctgca acgcgcccct 960 ccctggccct ggaccctatc gtacagaacc
tgctaaggcc atcaaaccta ttgatcggaa 1020 gtcagtccat cagatttgct
ctgggccagt ggtactgagt ctaagcactg cagtgaagga 1080 gttagtagaa
aacagtctgg atgctggtgc cactaatatt gatctaaagc ttaaggacta 1140
tggaatggat ctcattgaag tttcaggcaa tggatgtggg gtagaagaag aaaacttcga
1200 aggcttaatg atgtcaccat ttctacctgc cacgtctcgg cgaaggttgg
gactcgactg 1260 gtgtttgatc acgatgggaa aatcatccag aagaccccct
acccccaccc cagagggacc 1320 acagtcagcg tgaagcagtt attttctacg
ctacctgtgc gccataagga atttcaaagg 1380 aatattaaga agaaacatgc
tgcttcccct tcgccttctg ccgtgattgt cagttttaac 1440 cggaa 1445
<210> SEQ ID NO 26 <211> LENGTH: 270 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 26 Met
Glu Lys Leu Ser Ala Ala Ser Gly Tyr Ser Asp Val Thr Asp Ser 1 5 10
15 Lys Ala Met Gly Pro Leu Ala Val Gly Cys Leu Thr Lys Cys Ser His
20 25 30 Ala Phe His Leu Leu Cys Leu Leu Ala Met Tyr Cys Asn Gly
Asn Lys 35 40 45 Gly Pro Glu His Pro Asn Pro Gly Lys Pro Phe Thr
Ala Arg Gly Phe 50 55 60 Pro Ala Ser Ala Thr Phe Gln Thr Thr Pro
Gly Pro Gln Ala Ser Arg 65 70 75 80 Gly Phe Gln Asn Pro Glu Thr Leu
Ala Asp Ile Pro Ala Ser Pro Gln 85 90 95 Leu Leu Thr Asp Gly His
Tyr Met Thr Leu Pro Val Ser Pro Asp Gln 100 105 110 Leu Pro Cys Asp
Asp Pro Met Ala Gly Ser Gly Gly Ala Pro Val Leu 115 120 125 Arg Val
Gly His Asp His Gly Cys His Gln Gln Pro Arg Ile Cys Asn 130 135 140
Ala Pro Leu Pro Gly Pro Gly Pro Tyr Arg Thr Glu Pro Ala Lys Ala 145
150 155 160 Ile Lys Pro Ile Asp Arg Lys Ser Val His Gln Ile Cys Ser
Gly Pro 165 170 175 Val Val Leu Ser Leu Ser Thr Ala Val Lys Glu Leu
Val Glu Asn Ser 180 185 190 Leu Asp Ala Gly Ala Thr Asn Ile Asp Leu
Lys Leu Lys Asp Tyr Gly 195 200 205 Met Asp Leu Ile Glu Val Ser Gly
Asn Gly Cys Gly Val Glu Glu Glu 210 215 220 Asn Phe Glu Gly Leu Met
Met Ser Pro Phe Leu Pro Ala Thr Ser Arg 225 230 235 240 Arg Arg Leu
Gly Leu Asp Trp Cys Leu Ile Thr Met Gly Lys Ser Ser 245 250 255 Arg
Arg Pro Pro Thr Pro Thr Pro Glu Gly Pro Gln Ser Ala 260 265 270
<210> SEQ ID NO 27 <211> LENGTH: 795 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 27
atgtgtcctt ggcggcctag actaggccgt cgctgtatgg tgagccccag ggaggcggat
60 ctgggccccc agaaggacac ccgcctggat ttgccccgta gcccggcccg
ggcccctcgg 120 gagcagaaca gccttggtga ggtggacagg aggggacctc
gcgagcagac gcgcgcgcca 180 gcgacagcag ccccgccccg gcctctcggg
agccgggggg cagaggctgc ggagccccag 240 gagggtctat cagccacagt
ctctgcatgt ttccaagagc aacaggaaat gaacacattg 300 caggggccag
tgtcattcaa agatgtggct gtggatttca cccaggagga gtggcggcaa 360
ctggaccctg atgagaagat agcatacggg gatgtgatgt tggagaacta cagccatcta
420 gtttctgtgg ggtatgatta tcaccaagcc aaacatcatc atggagtgga
ggtgaaggaa 480 gtggagcagg gagaggagcc gtggataatg gaaggtgaat
ttccatgtca acatagtcca 540 gaacctgcta aggccatcaa acctattgat
cggaagtcag tccatcagat ttgctctggg 600 ccagtggtac tgagtctaag
cactgcagtg aaggagttag tagaaaacag tctggatgct 660 ggtgccacta
atattgatct aaagcttaag gactatggag tggatctcat tgaagtttca 720
gacaatggat gtggggtaga agaagaaaac tttgaaggct taatctcttt cagctctgaa
780 acatcacaca tgtaa 795 <210> SEQ ID NO 28 <211>
LENGTH: 260 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 28 Met Cys Pro Trp Arg Pro Arg Leu
Gly Arg Arg Cys Met Val Ser Pro 1 5 10 15 Arg Glu Ala Asp Leu Gly
Pro Gln Lys Asp Thr Arg Leu Asp Leu Pro 20 25 30 Arg Ser Pro Ala
Arg Ala Pro Arg Glu Gln Asn Ser Leu Gly Glu Val 35 40 45 Asp Arg
Arg Gly Pro Arg Glu Gln Thr Arg Ala Pro Ala Thr Ala Ala 50 55 60
Pro Pro Arg Pro Leu Gly Ser Arg Gly Ala Glu Ala Ala Glu Pro Gln 65
70 75 80 Glu Gly Leu Ser Ala Thr Val Ser Ala Cys Phe Gln Glu Gln
Gln Glu 85 90 95 Met Asn Thr Leu Gln Gly Pro Val Ser Phe Lys Asp
Val Ala Val Asp 100 105 110 Phe Thr Gln Glu Glu Trp Arg Gln Leu Asp
Pro Asp Glu Lys Ile Ala 115 120 125 Tyr Gly Asp Val Met Leu Glu Asn
Tyr Ser His Leu Val Ser Val Gly 130 135 140 Tyr Asp Tyr His Gln Ala
Lys His His His Gly Val Glu Val Lys Glu 145 150 155 160 Val Glu Gln
Gly Glu Glu Pro Trp Ile Met Glu Gly Glu Phe Pro Cys 165 170 175 Gln
His Ser Pro Glu Pro Ala Lys Ala Ile Lys Pro Ile Asp Arg Lys 180 185
190 Ser Val His Gln Ile Cys Ser Gly Pro Val Val Leu Ser Leu Ser Thr
195 200 205 Ala Val Lys Glu Leu Val Glu Asn Ser Leu Asp Ala Gly Ala
Thr Asn 210 215 220 Ile Asp Leu Lys Leu Lys Asp Tyr Gly Val Asp Leu
Ile Glu Val Ser 225 230 235 240 Asp Asn Gly Cys Gly Val Glu Glu Glu
Asn Phe Glu Gly Leu Ile Ser 245 250 255 Phe Ser Ser Glu 260
<210> SEQ ID NO 29 <211> LENGTH: 3218 <212> TYPE:
DNA <213> ORGANISM: Saccharomyces cerevisiae <400>
SEQUENCE: 29 aaataggaat gtgatacctt ctattgcatg caaagatagt gtaggaggcg
ctgctattgc 60 caaagacttt tgagaccgct tgctgtttca ttatagttga
ggagttctcg aagacgagaa 120 attagcagtt ttcggtgttt agtaatcgcg
ctagcatgct aggacaattt aactgcaaaa 180 ttttgatacg atagtgatag
taaatggaag gtaaaaataa catagaccta tcaataagca 240 atgtctctca
gaataaaagc acttgatgca tcagtggtta acaaaattgc tgcaggtgag 300
atcataatat cccccgtaaa tgctctcaaa gaaatgatgg agaattccat cgatgcgaat
360 gctacaatga ttgatattct agtcaaggaa ggaggaatta aggtacttca
aataacagat 420 aacggatctg gaattaataa agcagacctg ccaatcttat
gtgagcgatt cacgacgtcc 480 aaattacaaa aattcgaaga tttgagtcag
attcaaacgt atggattccg aggagaagct 540 ttagccagta tctcacatgt
ggcaagagtc acagtaacga caaaagttaa agaagacaga 600 tgtgcatgga
gagtttcata tgcagaaggt aagatgttgg aaagccccaa acctgttgct 660
ggaaaagacg gtaccacgat cctagttgaa gacctttttt tcaatattcc ttctagatta
720 agggccttga ggtcccataa tgatgaatac tctaaaatat tagatgttgt
cgggcgatac 780 gccattcatt ccaaggacat tggcttttct tgtaaaaagt
tcggagactc taattattct 840 ttatcagtta aaccttcata tacagtccag
gataggatta ggactgtgtt caataaatct 900 gtggcttcga atttaattac
ttttcatatc agcaaagtag aagatttaaa cctggaaagc 960 gttgatggaa
aggtgtgtaa tttgaatttc atatccaaaa agtccatttc attaattttt 1020
ttcattaata atagactagt gacatgtgat cttctaagaa gagctttgaa cagcgtttac
1080 tccaattatc tgccaaaggg cttcagacct tttatttatt tgggaattgt
tatagatccg 1140 gcggctgttg atgttaacgt tcacccgaca aagagagagg
ttcgtttcct gagccaagat 1200 gagatcatag agaaaatcgc caatcaattg
cacgccgaat tatctgccat tgatacttca 1260 cgtactttca aggcttcttc
aatttcaaca aacaagccag agtcattgat accatttaat 1320 gacaccatag
aaagtgatag gaataggaag agtctccgac aagcccaagt ggtagagaat 1380
tcatatacga cagccaatag tcaactaagg aaagcgaaaa gacaagagaa taaactagtc
1440 agaatagatg cttcacaagc taaaattacg tcatttttat cctcaagtca
acagttcaac 1500 tttgaaggat cgtctacaaa gcgacaactg agtgaaccca
aggtaacaaa tgtaagccac 1560 tcccaagagg cagaaaagct gacactaaat
gaaagcgaac aaccgcgtga tgccaataca 1620 atcaatgata atgacttgaa
ggatcaacct aagaagaaac aaaagttggg ggattataaa 1680 gttccaagca
ttgccgatga cgaaaagaat gcactcccga tttcaaaaga cgggtatatt 1740
agagtaccta aggagcgagt taatgttaat cttacgagta tcaagaaatt gcgtgaaaaa
1800 gtagatgatt cgatacatcg agaactaaca gacatttttg caaatttgaa
ttacgttggg 1860 gttgtagatg aggaaagaag attagccgct attcagcatg
acttaaagct ttttttaata 1920 gattacggat ctgtgtgcta tgagctattc
tatcagattg gtttgacaga cttcgcaaac 1980 tttggtaaga taaacctaca
gagtacaaat gtgtcagatg atatagtttt gtataatctc 2040 ctatcagaat
ttgacgagtt aaatgacgat gcttccaaag aaaaaataat tagtaaaata 2100
tgggacatga gcagtatgct aaatgagtac tattccatag aattggtgaa tgatggtcta
2160 gataatgact taaagtctgt gaagctaaaa tctctaccac tacttttaaa
aggctacatt 2220 ccatctctgg tcaagttacc attttttata tatcgcctgg
gtaaagaagt tgattgggag 2280 gatgaacaag agtgtctaga tggtatttta
agagagattg cattactcta tatacctgat 2340 atggttccga aagtcgatac
actcgatgca tcgttgtcag aagacgaaaa agcccagttt 2400 ataaatagaa
aggaacacat atcctcatta ctagaacacg ttctcttccc ttgtatcaaa 2460
cgaaggttcc tggcccctag acacattctc aaggatgtcg tggaaatagc caaccttcca
2520 gatctataca aagtttttga gaggtgttaa ctttaaaacg ttttggctgt
aataccaaag 2580 tttttgttta tttcctgagt gtgattgtgt ttcatttgaa
agtgtatgcc ctttccttta 2640 acgattcatc cgcgagattt caaaggatat
gaaatatggt tgcagttagg aaagtatgtc 2700 agaaatgtat attcggattg
aaactcttct aatagttctg aagtcacttg gttccgtatt 2760 gttttcgtcc
tcttcctcaa gcaacgattc ttgtctaagc ttattcaacg gtaccaaaga 2820
cccgagtcct tttatgagag aaaacatttc atcatttttc aactcaatta tcttaatatc
2880 attttgtagt attttgaaaa caggatggta aaacgaatca cctgaatcta
gaagctgtac 2940 cttgtcccat aaaagtttta atttactgag cctttcggtc
aagtaaacta gtttatctag 3000 ttttgaaccg aatattgtgg gcagatttgc
agtaagttca gttagatcta ctaaaagttg 3060 tttgacagca gccgattcca
caaaaatttg gtaaaaggag atgaaagaga cctcgcgcgt 3120 aatggtttgc
atcaccatcg gatgtctgtt gaaaaactca ctttttgcat ggaagttatt 3180
aacaataaga ctaatgatta ccttagaata atgtataa 3218 <210> SEQ ID
NO 30 <211> LENGTH: 769 <212> TYPE: PRT <213>
ORGANISM: Saccharomyces cerevisiae <400> SEQUENCE: 30 Met Ser
Leu Arg Ile Lys Ala Leu Asp Ala Ser Val Val Asn Lys Ile 1 5 10 15
Ala Ala Gly Glu Ile Ile Ile Ser Pro Val Asn Ala Leu Lys Glu Met 20
25 30 Met Glu Asn Ser Ile Asp Ala Asn Ala Thr Met Ile Asp Ile Leu
Val 35 40 45 Lys Glu Gly Gly Ile Lys Val Leu Gln Ile Thr Asp Asn
Gly Ser Gly 50 55 60 Ile Asn Lys Ala Asp Leu Pro Ile Leu Cys Glu
Arg Phe Thr Thr Ser 65 70 75 80 Lys Leu Gln Lys Phe Glu Asp Leu Ser
Gln Ile Gln Thr Tyr Gly Phe 85 90 95 Arg Gly Glu Ala Leu Ala Ser
Ile Ser His Val Ala Arg Val Thr Val 100 105 110 Thr Thr Lys Val Lys
Glu Asp Arg Cys Ala Trp Arg Val Ser Tyr Ala 115 120 125 Glu Gly Lys
Met Leu Glu Ser Pro Lys Pro Val Ala Gly Lys Asp Gly 130 135 140 Thr
Thr Ile Leu Val Glu Asp Leu Phe Phe Asn Ile Pro Ser Arg Leu 145 150
155 160 Arg Ala Leu Arg Ser His Asn Asp Glu Tyr Ser Lys Ile Leu Asp
Val 165 170 175 Val Gly Arg Tyr Ala Ile His Ser Lys Asp Ile Gly Phe
Ser Cys Lys 180 185 190 Lys Phe Gly Asp Ser Asn Tyr Ser Leu Ser Val
Lys Pro Ser Tyr Thr 195 200 205 Val Gln Asp Arg Ile Arg Thr Val Phe
Asn Lys Ser Val Ala Ser Asn 210 215 220 Leu Ile Thr Phe His Ile Ser
Lys Val Glu Asp Leu Asn Leu Glu Ser 225 230 235 240 Val Asp Gly Lys
Val Cys Asn Leu Asn Phe Ile Ser Lys Lys Ser Ile 245 250 255 Ser Leu
Ile Phe Phe Ile Asn Asn Arg Leu Val Thr Cys Asp Leu Leu 260 265 270
Arg Arg Ala Leu Asn Ser Val Tyr Ser Asn Tyr Leu Pro Lys Gly Phe 275
280 285 Arg Pro Phe Ile Tyr Leu Gly Ile Val Ile Asp Pro Ala Ala Val
Asp 290 295 300 Val Asn Val His Pro Thr Lys Arg Glu Val Arg Phe Leu
Ser Gln Asp 305 310 315 320 Glu Ile Ile Glu Lys Ile Ala Asn Gln Leu
His Ala Glu Leu Ser Ala 325 330 335 Ile Asp Thr Ser Arg Thr Phe Lys
Ala Ser Ser Ile Ser Thr Asn Lys 340 345 350 Pro Glu Ser Leu Ile Pro
Phe Asn Asp Thr Ile Glu Ser Asp Arg Asn 355 360 365 Arg Lys Ser Leu
Arg Gln Ala Gln Val Val Glu Asn Ser Tyr Thr Thr 370 375 380 Ala Asn
Ser Gln Leu Arg Lys Ala Lys Arg Gln Glu Asn Lys Leu Val 385 390 395
400 Arg Ile Asp Ala Ser Gln Ala Lys Ile Thr Ser Phe Leu Ser Ser Ser
405 410 415 Gln Gln Phe Asn Phe Glu Gly Ser Ser Thr Lys Arg Gln Leu
Ser Glu 420 425 430 Pro Lys Val Thr Asn Val Ser His Ser Gln Glu Ala
Glu Lys Leu Thr 435 440 445 Leu Asn Glu Ser Glu Gln Pro Arg Asp Ala
Asn Thr Ile Asn Asp Asn 450 455 460 Asp Leu Lys Asp Gln Pro Lys Lys
Lys Gln Lys Leu Gly Asp Tyr Lys 465 470 475 480 Val Pro Ser Ile Ala
Asp Asp Glu Lys Asn Ala Leu Pro Ile Ser Lys 485 490 495 Asp Gly Tyr
Ile Arg Val Pro Lys Glu Arg Val Asn Val Asn Leu Thr 500 505 510 Ser
Ile Lys Lys Leu Arg Glu Lys Val Asp Asp Ser Ile His Arg Glu 515 520
525 Leu Thr Asp Ile Phe Ala Asn Leu Asn Tyr Val Gly Val Val Asp Glu
530 535 540 Glu Arg Arg Leu Ala Ala Ile Gln His Asp Leu Lys Leu Phe
Leu Ile 545 550 555 560 Asp Tyr Gly Ser Val Cys Tyr Glu Leu Phe Tyr
Gln Ile Gly Leu Thr 565 570 575 Asp Phe Ala Asn Phe Gly Lys Ile Asn
Leu Gln Ser Thr Asn Val Ser 580 585 590 Asp Asp Ile Val Leu Tyr Asn
Leu Leu Ser Glu Phe Asp Glu Leu Asn 595 600 605 Asp Asp Ala Ser Lys
Glu Lys Ile Ile Ser Lys Ile Trp Asp Met Ser 610 615 620 Ser Met Leu
Asn Glu Tyr Tyr Ser Ile Glu Leu Val Asn Asp Gly Leu 625 630 635 640
Asp Asn Asp Leu Lys Ser Val Lys Leu Lys Ser Leu Pro Leu Leu Leu 645
650 655 Lys Gly Tyr Ile Pro Ser Leu Val Lys Leu Pro Phe Phe Ile Tyr
Arg 660 665 670 Leu Gly Lys Glu Val Asp Trp Glu Asp Glu Gln Glu Cys
Leu Asp Gly 675 680 685 Ile Leu Arg Glu Ile Ala Leu Leu Tyr Ile Pro
Asp Met Val Pro Lys 690 695 700 Val Asp Thr Leu Asp Ala Ser Leu Ser
Glu Asp Glu Lys Ala Gln Phe 705 710 715 720 Ile Asn Arg Lys Glu His
Ile Ser Ser Leu Leu Glu His Val Leu Phe 725 730 735 Pro Cys Ile Lys
Arg Arg Phe Leu Ala Pro Arg His Ile Leu Lys Asp 740 745 750 Val Val
Glu Ile Ala Asn Leu Pro Asp Leu Tyr Lys Val Phe Glu Arg 755 760 765
Cys <210> SEQ ID NO 31 <211> LENGTH: 3056 <212>
TYPE: DNA <213> ORGANISM: Mus musculus <400> SEQUENCE:
31 gaattccggt gaaggtcctg aagaatttcc agattcctga gtatcattgg
aggagacaga 60 taacctgtcg tcaggtaacg atggtgtata tgcaacagaa
atgggtgttc ctggagacgc 120 gtcttttccc gagagcggca ccgcaactct
cccgcggtga ctgtgactgg aggagtcctg 180 catccatgga gcaaaccgaa
ggcgtgagta cagaatgtgc taaggccatc aagcctattg 240 atgggaagtc
agtccatcaa atttgttctg ggcaggtgat actcagttta agcaccgctg 300
tgaaggagtt gatagaaaat agtgtagatg ctggtgctac tactattgat ctaaggctta
360 aagactatgg ggtggacctc attgaagttt cagacaatgg atgtggggta
gaagaagaaa 420 actttgaagg tctagctctg aaacatcaca catctaagat
tcaagagttt gccgacctca 480 cgcaggttga aactttcggc tttcgggggg
aagctctgag ctctctgtgt gcactaagtg 540 atgtcactat atctacctgc
cacgggtctg caagcgttgg gactcgactg gtgtttgacc 600 ataatgggaa
aatcacccag aaaactccct acccccgacc taaaggaacc acagtcagtg 660
tgcagcactt attttataca ctacccgtgc gttacaaaga gtttcagagg aacattaaaa
720 aggagtattc caaaatggtg caggtcttac aggcgtactg tatcatctca
gcaggcgtcc 780 gtgtaagctg cactaatcag ctcggacagg ggaagcggca
cgctgtggtg tgcacaagcg 840 gcacgtctgg catgaaggaa aatatcgggt
ctgtgtttgg ccagaagcag ttgcaaagcc 900 tcattccttt tgttcagctg
ccccctagtg acgctgtgtg tgaagagtac ggcctgagca 960 cttcaggacg
ccacaaaacc ttttctacgt ttcgggcttc atttcacagt gcacgcacgg 1020
cgccgggagg agtgcaacag acaggcagtt tttcttcatc aatcagaggc cctgtgaccc
1080 agcaaaggtc tctaagcttg tcaatgaggt tttatcacat gtataaccgg
catcagtacc 1140 catttgtcgt ccttaacgtt tccgttgact cagaatgtgt
ggatattaat gtaactccag 1200 ataaaaggca aattctacta caagaagaga
agctattgct ggccgtttta aagacctcct 1260 tgataggaat gtttgacagt
gatgcaaaca agcttaatgt caaccagcag ccactgctag 1320 atgttgaagg
taacttagta aagctgcata ctgcagaact agaaaagcct gtgccaggaa 1380
agcaagataa ctctccttca ctgaagagca cagcagacga gaaaagggta gcatccatct
1440 ccaggctgag agaggccttt tctcttcatc ctactaaaga gatcaagtct
aggggtccag 1500 agactgctga actgacacgg agttttccaa gtgagaaaag
gggcgtgtta tcctcttatc 1560 cttcagacgt catctcttac agaggcctcc
gtggctcgca ggacaaattg gtgagtccca 1620 cggacagccc tggtgactgt
atggacagag agaaaataga aaaagactca gggctcagca 1680 gcacctcagc
tggctctgag gaagagttca gcaccccaga agtggccagt agctttagca 1740
gtgactataa cgtgagctcc ctagaagaca gaccttctca ggaaaccata aactgtggtg
1800 acctggactg ccgtcctcca ggtacaggac agtccttgaa gccagaagac
catggatatc 1860 aatgcaaagc tctacctcta gctcgtctgt cacccacaaa
tgccaagcgc ttcaagacag 1920 aggaaagacc ctcaaatgtc aacatttctc
aaagattgcc tggtcctcag agcacctcag 1980 cagctgaggt cgatgtagcc
ataaaaatga ataagagaat cgtgctcctc gagttctctc 2040 tgagttctct
agctaagcga atgaagcagt tacagcacct aaaggcgcag aacaaacatg 2100
aactgagtta cagaaaattt agggccaaga tttgccctgg agaaaaccaa gcagcagaag
2160 atgaactcag aaaagagatt agtaaatcga tgtttgcaga gatggagatc
ttgggtcagt 2220 ttaacctggg atttatagta accaaactga aagaggacct
cttcctggtg gaccagcatg 2280 ctgcggatga gaagtacaac tttgagatgc
tgcagcagca cacggtgctc caggcgcaga 2340 ggctcatcac accccagact
ctgaacttaa ctgctgtcaa tgaagctgta ctgatagaaa 2400 atctggaaat
attcagaaag aatggctttg actttgtcat tgatgaggat gctccagtca 2460
ctgaaagggc taaattgatt tccttaccaa ctagtaaaaa ctggaccttt ggaccccaag
2520 atatagatga actgatcttt atgttaagtg acagccctgg ggtcatgtgc
cggccctcac 2580 gagtcagaca gatgtttgct tccagagcct gtcggaagtc
agtgatgatt ggaacggcgc 2640 tcaatgcgag cgagatgaag aagctcatca
cccacatggg tgagatggac cacccctgga 2700 actgccccca cggcaggcca
accatgaggc acgttgccaa tctggatgtc atctctcaga 2760 actgacacac
cccttgtagc atagagttta ttacagattg ttcggtttgc aaagagaagg 2820
ttttaagtaa tctgattatc gttgtacaaa aattagcatg ctgctttaat gtactggatc
2880 catttaaaag cagtgttaag gcaggcatga tggagtgttc ctctagctca
gctacttggg 2940 tgatccggtg ggagctcatg tgagcccagg actttgagac
cactccgagc cacattcatg 3000 agactcaatt caaggacaaa aaaaaaaaga
tatttttgaa gccttttaaa aaaaaa 3056 <210> SEQ ID NO 32
<211> LENGTH: 859 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 32 Met Glu Gln Thr Glu Gly Val
Ser Thr Glu Cys Ala Lys Ala Ile Lys 1 5 10 15 Pro Ile Asp Gly Lys
Ser Val His Gln Ile Cys Ser Gly Gln Val Ile 20 25 30 Leu Ser Leu
Ser Thr Ala Val Lys Glu Leu Ile Glu Asn Ser Val Asp 35 40 45 Ala
Gly Ala Thr Thr Ile Asp Leu Arg Leu Lys Asp Tyr Gly Val Asp 50 55
60 Leu Ile Glu Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu Asn Phe
65 70 75 80 Glu Gly Leu Ala Leu Lys His His Thr Ser Lys Ile Gln Glu
Phe Ala 85 90 95 Asp Leu Thr Gln Val Glu Thr Phe Gly Phe Arg Gly
Glu Ala Leu Ser 100 105 110 Ser Leu Cys Ala Leu Ser Asp Val Thr Ile
Ser Thr Cys His Gly Ser 115 120 125 Ala Ser Val Gly Thr Arg Leu Val
Phe Asp His Asn Gly Lys Ile Thr 130 135 140 Gln Lys Thr Pro Tyr Pro
Arg Pro Lys Gly Thr Thr Val Ser Val Gln 145 150 155 160 His Leu Phe
Tyr Thr Leu Pro Val Arg Tyr Lys Glu Phe Gln Arg Asn 165 170 175 Ile
Lys Lys Glu Tyr Ser Lys Met Val Gln Val Leu Gln Ala Tyr Cys 180 185
190 Ile Ile Ser Ala Gly Val Arg Val Ser Cys Thr Asn Gln Leu Gly Gln
195 200 205 Gly Lys Arg His Ala Val Val Cys Thr Ser Gly Thr Ser Gly
Met Lys 210 215 220 Glu Asn Ile Gly Ser Val Phe Gly Gln Lys Gln Leu
Gln Ser Leu Ile 225 230 235 240 Pro Phe Val Gln Leu Pro Pro Ser Asp
Ala Val Cys Glu Glu Tyr Gly 245 250 255 Leu Ser Thr Ser Gly Arg His
Lys Thr Phe Ser Thr Phe Arg Ala Ser 260 265 270 Phe His Ser Ala Arg
Thr Ala Pro Gly Gly Val Gln Gln Thr Gly Ser 275 280 285 Phe Ser Ser
Ser Ile Arg Gly Pro Val Thr Gln Gln Arg Ser Leu Ser 290 295 300 Leu
Ser Met Arg Phe Tyr His Met Tyr Asn Arg His Gln Tyr Pro Phe 305 310
315 320 Val Val Leu Asn Val Ser Val Asp Ser Glu Cys Val Asp Ile Asn
Val 325 330 335 Thr Pro Asp Lys Arg Gln Ile Leu Leu Gln Glu Glu Lys
Leu Leu Leu 340 345 350 Ala Val Leu Lys Thr Ser Leu Ile Gly Met Phe
Asp Ser Asp Ala Asn 355 360 365 Lys Leu Asn Val Asn Gln Gln Pro Leu
Leu Asp Val Glu Gly Asn Leu 370 375 380 Val Lys Leu His Thr Ala Glu
Leu Glu Lys Pro Val Pro Gly Lys Gln 385 390 395 400 Asp Asn Ser Pro
Ser Leu Lys Ser Thr Ala Asp Glu Lys Arg Val Ala 405 410 415 Ser Ile
Ser Arg Leu Arg Glu Ala Phe Ser Leu His Pro Thr Lys Glu 420 425 430
Ile Lys Ser Arg Gly Pro Glu Thr Ala Glu Leu Thr Arg Ser Phe Pro 435
440 445 Ser Glu Lys Arg Gly Val Leu Ser Ser Tyr Pro Ser Asp Val Ile
Ser 450 455 460 Tyr Arg Gly Leu Arg Gly Ser Gln Asp Lys Leu Val Ser
Pro Thr Asp 465 470 475 480 Ser Pro Gly Asp Cys Met Asp Arg Glu Lys
Ile Glu Lys Asp Ser Gly 485 490 495 Leu Ser Ser Thr Ser Ala Gly Ser
Glu Glu Glu Phe Ser Thr Pro Glu 500 505 510 Val Ala Ser Ser Phe Ser
Ser Asp Tyr Asn Val Ser Ser Leu Glu Asp 515 520 525 Arg Pro Ser Gln
Glu Thr Ile Asn Cys Gly Asp Leu Asp Cys Arg Pro 530 535 540 Pro Gly
Thr Gly Gln Ser Leu Lys Pro Glu Asp His Gly Tyr Gln Cys 545 550 555
560 Lys Ala Leu Pro Leu Ala Arg Leu Ser Pro Thr Asn Ala Lys Arg Phe
565 570 575 Lys Thr Glu Glu Arg Pro Ser Asn Val Asn Ile Ser Gln Arg
Leu Pro 580 585 590 Gly Pro Gln Ser Thr Ser Ala Ala Glu Val Asp Val
Ala Ile Lys Met 595 600 605 Asn Lys Arg Ile Val Leu Leu Glu Phe Ser
Leu Ser Ser Leu Ala Lys 610 615 620 Arg Met Lys Gln Leu Gln His Leu
Lys Ala Gln Asn Lys His Glu Leu 625 630 635 640 Ser Tyr Arg Lys Phe
Arg Ala Lys Ile Cys Pro Gly Glu Asn Gln Ala 645 650 655 Ala Glu Asp
Glu Leu Arg Lys Glu Ile Ser Lys Ser Met Phe Ala Glu 660 665 670 Met
Glu Ile Leu Gly Gln Phe Asn Leu Gly Phe Ile Val Thr Lys Leu 675 680
685 Lys Glu Asp Leu Phe Leu Val Asp Gln His Ala Ala Asp Glu Lys Tyr
690 695 700 Asn Phe Glu Met Leu Gln Gln His Thr Val Leu Gln Ala Gln
Arg Leu 705 710 715 720 Ile Thr Pro Gln Thr Leu Asn Leu Thr Ala Val
Asn Glu Ala Val Leu 725 730 735 Ile Glu Asn Leu Glu Ile Phe Arg Lys
Asn Gly Phe Asp Phe Val Ile 740 745 750 Asp Glu Asp Ala Pro Val Thr
Glu Arg Ala Lys Leu Ile Ser Leu Pro 755 760 765 Thr Ser Lys Asn Trp
Thr Phe Gly Pro Gln Asp Ile Asp Glu Leu Ile 770 775 780 Phe Met Leu
Ser Asp Ser Pro Gly Val Met Cys Arg Pro Ser Arg Val 785 790 795 800
Arg Gln Met Phe Ala Ser Arg Ala Cys Arg Lys Ser Val Met Ile Gly 805
810 815 Thr Ala Leu Asn Ala Ser Glu Met Lys Lys Leu Ile Thr His Met
Gly 820 825 830 Glu Met Asp His Pro Trp Asn Cys Pro His Gly Arg Pro
Thr Met Arg 835 840 845 His Val Ala Asn Leu Asp Val Ile Ser Gln Asn
850 855 <210> SEQ ID NO 33 <211> LENGTH: 399
<212> TYPE: DNA <213> ORGANISM: Mus musculus
<400> SEQUENCE: 33 atggagcaaa ccgaaggcgt gagtacagaa
tgtgctaagg ccatcaagcc tattgatggg 60 aagtcagtcc atcaaatttg
ttctgggcag gtgatactca gtttaagcac cgctgtgaag 120 gagttgatag
aaaatagtgt agatgctggt gctactacta ttgatctaag gcttaaagac 180
tatggggtgg acctcattga agtttcagac aatggatgtg gggtagaaga agaaaacttt
240 gaaggtctag ctctgaaaca tcacacatct aagattcaag agtttgccga
cctcacgcag 300 gttgaaactt tcggctttcg gggggaagct ctgagctctc
tgtgtgcact aagtgatgtc 360 actatatcta cctgccacgg gtctgcaagc
gttgggact 399 <210> SEQ ID NO 34 <211> LENGTH: 133
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 34 Met Glu Gln Thr Glu Gly Val Ser Thr Glu
Cys Ala Lys Ala Ile Lys 1 5 10 15 Pro Ile Asp Gly Lys Ser Val His
Gln Ile Cys Ser Gly Gln Val Ile 20 25 30 Leu Ser Leu Ser Thr Ala
Val Lys Glu Leu Ile Glu Asn Ser Val Asp 35 40 45 Ala Gly Ala Thr
Thr Ile Asp Leu Arg Leu Lys Asp Tyr Gly Val Asp 50 55 60 Leu Ile
Glu Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu Asn Phe 65 70 75 80
Glu Gly Leu Ala Leu Lys His His Thr Ser Lys Ile Gln Glu Phe Ala 85
90 95 Asp Leu Thr Gln Val Glu Thr Phe Gly Phe Arg Gly Glu Ala Leu
Ser 100 105 110 Ser Leu Cys Ala Leu Ser Asp Val Thr Ile Ser Thr Cys
His Gly Ser 115 120 125 Ala Ser Val Gly Thr 130 <210> SEQ ID
NO 35 <211> LENGTH: 3099 <212> TYPE: DNA <213>
ORGANISM: Arabidopsis thaliana <400> SEQUENCE: 35 gtcttcttct
tcatccttgt ctcaccttcg attttggcgg caaaacataa accctaaggg 60
ttttctcact ctctctctct cttctcacac acacagtccc agagtacggt ggtgttgatt
120 cgattgagga gattcatctg tttatagggt ttagcaaatg caaggagatt
cttctccgtc 180 tccgacgact actagctctc ctttgataag acctataaac
agaaacgtaa ttcacagaat 240 ctgttccggt caagtcatct tagacctctc
ttcggccgtc aaggagcttg tcgagaatag 300 tctcgacgcc ggcgccacca
gtatagagat taacctccga gactacggcg aagactattt 360 tcaggtcatt
gacaatggtt gtggcatttc cccaaccaat ttcaaggttc ttgcacttaa 420
gcatcatact tctaaattag aggatttcac agatcttttg aatttgacta cttatggttt
480 tagaggagaa gccttgagct ctctctgtgc attgggaaat ctcactgtgg
aaacaagaac 540 aaagaatgag ccagttgcta cgctcttgac gtttgatcat
tctggtttgc ttactgctga 600 aaagaagact gctcgccaaa ttggtaccac
tgtcactgtt aggaagttgt tctctaattt 660 acctgtacga agcaaagagt
ttaagcggaa tatacgcaaa gaatatggga agcttgtatc 720 tttattgaac
gcatatgcgc ttattgcgaa aggagtgcgg tttgtctgct ctaacacgac 780
tgggaaaaac ccaaagtctg ttgtgctgaa cacacaaggg aggggttcac ttaaagataa
840 tatcataaca gttttcggca ttagtacctt tacaagtcta cagcctgtaa
gtatatgtgt 900 atcagaagat tgtagagttg aagggtttct ttccaagcct
ggacagggta ctggacgcaa 960 tttagcagat cgacagtatt tctttataaa
tggtcggcct gtagatatgc caaaagtcag 1020 caagttggtg aatgagttat
ataaagatac aagttctcgg aaatatccag ttaccattct 1080 ggattttatt
gtgcctggtg gagcatgtga tttgaatgtc acgcccgata aaagaaaggt 1140
gttcttttct gacgagactt ctgttatcgg ttctttgagg gaaggtctga acgagatata
1200 ttcctccagt aatgcgtctt atattgttaa taggttcgag gagaattcgg
agcaaccaga 1260 taaggctgga gtttcgtcgt ttcagaagaa atcaaatctt
ttgtcagaag ggatagttct 1320 ggatgtcagt tctaaaacaa gactagggga
agctattgag aaagaaaatc catccttaag 1380 ggaggttgaa attgataata
gttcgccaat ggagaagttt aagtttgaga tcaaggcatg 1440 tgggacgaag
aaaggggaag gttctttatc agtccatgat gtaactcacc ttgacaagac 1500
acctagcaaa ggtttgcctc agttaaatgt gactgagaaa gttactgatg caagtaaaga
1560 cttgagcagc cgctctagct ttgcccagtc aactttgaat acttttgtta
ccatgggaaa 1620 aagaaaacat gaaaacataa gcaccatcct ctctgaaaca
cctgtcctca gaaaccaaac 1680 ttctagttat cgtgtggaga aaagcaaatt
tgaagttcgt gccttagctt caaggtgtct 1740 cgtggaaggc gatcaacttg
atgatatggt catctcaaag gaagatatga caccaagcga 1800 aagagattct
gaactaggca atcggatttc tcctggaaca caagctgata atgttgaaag 1860
acatgagaga gaacatgaaa agcctataag gtttgaagaa ccaacatcag ataacacact
1920 caccaagggg gatgtggaaa gggtttcaga ggacaatcca cggtgcagtc
agccactgcg 1980 atctgtggcc acagtgctgg attccccagc tcagtcaacc
ggtcctaaaa tgttttccac 2040 attagaattt agtttccaaa acctcaggac
aaggaggtta gagaggctgt cgagattgca 2100 gtccacaggt tatgtatcta
aatgtatgaa tacgccacag cctaaaaagt gctttgccgc 2160 tgcaacatta
gagttatctc aaccggatga tgaagagcga aaagcaaggg ctttagctgc 2220
agctacttct gagctggaaa ggctttttcg aaaagaggat ttcaggagaa tgcaggtact
2280 cgggcaattc aatcttgggt tcatcattgc aaaattggag cgagatctgt
tcattgtgga 2340 tcagcatgca gctgatgaga aattcaactt cgaacattta
gcaaggtcaa ctgtcctgaa 2400 ccagcaaccc ttactccagc ctttgaactt
ggaactctct ccagaagaag aagtaactgt 2460 gttaatgcac atggatatta
tcagggaaaa tggctttctt ctagaggaga atccaagtgc 2520 tcctcccgga
aaacacttta gactacgagc cattccttat agcaagaata tcacctttgg 2580
agtcgaagat cttaaagacc tgatctcaac tctaggagat aaccatgggg aatgttcggt
2640 tgctagtagc tacaaaacca gcaaaacaga ttcgatttgt ccatcacgag
tccgtgcaat 2700 gctagcatcc cgagcatgca gatcatctgt gatgatcgga
gatccactca gaaaaaacga 2760 aatgcagaag atagtagaac acttggcaga
tctcgaatct ccttggaatt gcccacacgg 2820 acgaccaaca atgcgtcatc
ttgtggactt gacaacttta ctcacattac ctgatgacga 2880 caatgtcaat
gatgatgatg atgatgatgc aaccatctca ttggcatgaa cactcaaaag 2940
tcttaacgta tttagatgtg agaatcctta agattaacat tgaggaacac tcggttataa
3000 ctacaatcgt aaatgtaaat tgtcttagtc tatatgatct ttttggtcac
aacaggtaat 3060 ttcattttcc tttgattact tctcgtgaaa aaacaaatt 3099
<210> SEQ ID NO 36 <211> LENGTH: 923 <212> TYPE:
PRT <213> ORGANISM: Arabidopsis thaliana <400>
SEQUENCE: 36 Met Gln Gly Asp Ser Ser Pro Ser Pro Thr Thr Thr Ser
Ser Pro Leu 1 5 10 15 Ile Arg Pro Ile Asn Arg Asn Val Ile His Arg
Ile Cys Ser Gly Gln 20 25 30 Val Ile Leu Asp Leu Ser Ser Ala Val
Lys Glu Leu Val Glu Asn Ser 35 40 45 Leu Asp Ala Gly Ala Thr Ser
Ile Glu Ile Asn Leu Arg Asp Tyr Gly 50 55 60 Glu Asp Tyr Phe Gln
Val Ile Asp Asn Gly Cys Gly Ile Ser Pro Thr 65 70 75 80 Asn Phe Lys
Val Leu Ala Leu Lys His His Thr Ser Lys Leu Glu Asp 85 90 95 Phe
Thr Asp Leu Leu Asn Leu Thr Thr Tyr Gly Phe Arg Gly Glu Ala 100 105
110 Leu Ser Ser Leu Cys Ala Leu Gly Asn Leu Thr Val Glu Thr Arg Thr
115 120 125 Lys Asn Glu Pro Val Ala Thr Leu Leu Thr Phe Asp His Ser
Gly Leu 130 135 140 Leu Thr Ala Glu Lys Lys Thr Ala Arg Gln Ile Gly
Thr Thr Val Thr 145 150 155 160 Val Arg Lys Leu Phe Ser Asn Leu Pro
Val Arg Ser Lys Glu Phe Lys 165 170 175 Arg Asn Ile Arg Lys Glu Tyr
Gly Lys Leu Val Ser Leu Leu Asn Ala 180 185 190 Tyr Ala Leu Ile Ala
Lys Gly Val Arg Phe Val Cys Ser Asn Thr Thr 195 200 205 Gly Lys Asn
Pro Lys Ser Val Val Leu Asn Thr Gln Gly Arg Gly Ser 210 215 220 Leu
Lys Asp Asn Ile Ile Thr Val Phe Gly Ile Ser Thr Phe Thr Ser 225 230
235 240 Leu Gln Pro Val Ser Ile Cys Val Ser Glu Asp Cys Arg Val Glu
Gly 245 250 255 Phe Leu Ser Lys Pro Gly Gln Gly Thr Gly Arg Asn Leu
Ala Asp Arg 260 265 270 Gln Tyr Phe Phe Ile Asn Gly Arg Pro Val Asp
Met Pro Lys Val Ser 275 280 285 Lys Leu Val Asn Glu Leu Tyr Lys Asp
Thr Ser Ser Arg Lys Tyr Pro 290 295 300 Val Thr Ile Leu Asp Phe Ile
Val Pro Gly Gly Ala Cys Asp Leu Asn 305 310 315 320 Val Thr Pro Asp
Lys Arg Lys Val Phe Phe Ser Asp Glu Thr Ser Val 325 330 335 Ile Gly
Ser Leu Arg Glu Gly Leu Asn Glu Ile Tyr Ser Ser Ser Asn 340 345 350
Ala Ser Tyr Ile Val Asn Arg Phe Glu Glu Asn Ser Glu Gln Pro Asp 355
360 365 Lys Ala Gly Val Ser Ser Phe Gln Lys Lys Ser Asn Leu Leu Ser
Glu 370 375 380 Gly Ile Val Leu Asp Val Ser Ser Lys Thr Arg Leu Gly
Glu Ala Ile 385 390 395 400 Glu Lys Glu Asn Pro Ser Leu Arg Glu Val
Glu Ile Asp Asn Ser Ser 405 410 415 Pro Met Glu Lys Phe Lys Phe Glu
Ile Lys Ala Cys Gly Thr Lys Lys 420 425 430 Gly Glu Gly Ser Leu Ser
Val His Asp Val Thr His Leu Asp Lys Thr 435 440 445 Pro Ser Lys Gly
Leu Pro Gln Leu Asn Val Thr Glu Lys Val Thr Asp 450 455 460 Ala Ser
Lys Asp Leu Ser Ser Arg Ser Ser Phe Ala Gln Ser Thr Leu 465 470 475
480 Asn Thr Phe Val Thr Met Gly Lys Arg Lys His Glu Asn Ile Ser Thr
485 490 495 Ile Leu Ser Glu Thr Pro Val Leu Arg Asn Gln Thr Ser Ser
Tyr Arg 500 505 510 Val Glu Lys Ser Lys Phe Glu Val Arg Ala Leu Ala
Ser Arg Cys Leu 515 520 525 Val Glu Gly Asp Gln Leu Asp Asp Met Val
Ile Ser Lys Glu Asp Met 530 535 540 Thr Pro Ser Glu Arg Asp Ser Glu
Leu Gly Asn Arg Ile Ser Pro Gly 545 550 555 560 Thr Gln Ala Asp Asn
Val Glu Arg His Glu Arg Glu His Glu Lys Pro 565 570 575 Ile Arg Phe
Glu Glu Pro Thr Ser Asp Asn Thr Leu Thr Lys Gly Asp 580 585 590 Val
Glu Arg Val Ser Glu Asp Asn Pro Arg Cys Ser Gln Pro Leu Arg 595 600
605 Ser Val Ala Thr Val Leu Asp Ser Pro Ala Gln Ser Thr Gly Pro Lys
610 615 620 Met Phe Ser Thr Leu Glu Phe Ser Phe Gln Asn Leu Arg Thr
Arg Arg 625 630 635 640 Leu Glu Arg Leu Ser Arg Leu Gln Ser Thr Gly
Tyr Val Ser Lys Cys 645 650 655 Met Asn Thr Pro Gln Pro Lys Lys Cys
Phe Ala Ala Ala Thr Leu Glu 660 665 670 Leu Ser Gln Pro Asp Asp Glu
Glu Arg Lys Ala Arg Ala Leu Ala Ala 675 680 685 Ala Thr Ser Glu Leu
Glu Arg Leu Phe Arg Lys Glu Asp Phe Arg Arg 690 695 700 Met Gln Val
Leu Gly Gln Phe Asn Leu Gly Phe Ile Ile Ala Lys Leu 705 710 715 720
Glu Arg Asp Leu Phe Ile Val Asp Gln His Ala Ala Asp Glu Lys Phe 725
730 735 Asn Phe Glu His Leu Ala Arg Ser Thr Val Leu Asn Gln Gln Pro
Leu 740 745 750 Leu Gln Pro Leu Asn Leu Glu Leu Ser Pro Glu Glu Glu
Val Thr Val 755 760 765 Leu Met His Met Asp Ile Ile Arg Glu Asn Gly
Phe Leu Leu Glu Glu 770 775 780 Asn Pro Ser Ala Pro Pro Gly Lys His
Phe Arg Leu Arg Ala Ile Pro 785 790 795 800 Tyr Ser Lys Asn Ile Thr
Phe Gly Val Glu Asp Leu Lys Asp Leu Ile 805 810 815 Ser Thr Leu Gly
Asp Asn His Gly Glu Cys Ser Val Ala Ser Ser Tyr 820 825 830 Lys Thr
Ser Lys Thr Asp Ser Ile Cys Pro Ser Arg Val Arg Ala Met 835 840 845
Leu Ala Ser Arg Ala Cys Arg Ser Ser Val Met Ile Gly Asp Pro Leu 850
855 860 Arg Lys Asn Glu Met Gln Lys Ile Val Glu His Leu Ala Asp Leu
Glu 865 870 875 880 Ser Pro Trp Asn Cys Pro His Gly Arg Pro Thr Met
Arg His Leu Val 885 890 895 Asp Leu Thr Thr Leu Leu Thr Leu Pro Asp
Asp Asp Asn Val Asn Asp 900 905 910 Asp Asp Asp Asp Asp Ala Thr Ile
Ser Leu Ala 915 920 <210> SEQ ID NO 37 <211> LENGTH:
399 <212> TYPE: DNA <213> ORGANISM: Arabidopsis
thaliana <400> SEQUENCE: 37 atgcaaggag attcttctcc gtctccgacg
actactagct ctcctttgat aagacctata 60 aacagaaacg taattcacag
aatctgttcc ggtcaagtca tcttagacct ctcttcggcc 120 gtcaaggagc
ttgtcgagaa tagtctcgac gccggcgcca ccagtataga gattaacctc 180
cgagactacg gcgaagacta ttttcaggtc attgacaatg gttgtggcat ttccccaacc
240 aatttcaagg ttcttgcact taagcatcat acttctaaat tagaggattt
cacagatctt 300 ttgaatttga ctacttatgg ttttagagga gaagccttga
gctctctctg tgcattggga 360 aatctcactg tggaaacaag aacaaagaat
gagccagtt 399 <210> SEQ ID NO 38 <211> LENGTH: 133
<212> TYPE: PRT <213> ORGANISM: Arabidopsis thaliana
<400> SEQUENCE: 38 Met Gln Gly Asp Ser Ser Pro Ser Pro Thr
Thr Thr Ser Ser Pro Leu 1 5 10 15 Ile Arg Pro Ile Asn Arg Asn Val
Ile His Arg Ile Cys Ser Gly Gln 20 25 30 Val Ile Leu Asp Leu Ser
Ser Ala Val Lys Glu Leu Val Glu Asn Ser 35 40 45 Leu Asp Ala Gly
Ala Thr Ser Ile Glu Ile Asn Leu Arg Asp Tyr Gly 50 55 60 Glu Asp
Tyr Phe Gln Val Ile Asp Asn Gly Cys Gly Ile Ser Pro Thr 65 70 75 80
Asn Phe Lys Val Leu Ala Leu Lys His His Thr Ser Lys Leu Glu Asp 85
90 95 Phe Thr Asp Leu Leu Asn Leu Thr Thr Tyr Gly Phe Arg Gly Glu
Ala 100 105 110 Leu Ser Ser Leu Cys Ala Leu Gly Asn Leu Thr Val Glu
Thr Arg Thr 115 120 125 Lys Asn Glu Pro Val 130 <210> SEQ ID
NO 39 <211> LENGTH: 2791 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (77)..(673) <300> PUBLICATION
INFORMATION: <308> DATABASE ACCESSION NUMBER: NM_02661
<309> DATABASE ENTRY DATE: 2003-12-13 <313> RELEVANT
RESIDUES IN SEQ ID NO: (1)..(2791) <400> SEQUENCE: 39
gaaccatcat taattgaagt gagatttttc tggcctgaga cttgcaggga ggcaagaaga
60 cactctggac accact atg gac agc ctc ttg atg aac cgg agg aag ttt
ctt 112 Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu 1 5 10 tac
caa ttc aaa aat gtc cgc tgg gct aag ggt cgg cgt gag acc tac 160 Tyr
Gln Phe Lys Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr 15 20
25 ctg tgc tac gta gtg aag agg cgt gac agt gct aca tcc ttt tca ctg
208 Leu Cys Tyr Val Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu
30 35 40 gac ttt ggt tat ctt cgc aat aag aac ggc tgc cac gtg gaa
ttg ctc 256 Asp Phe Gly Tyr Leu Arg Asn Lys Asn Gly Cys His Val Glu
Leu Leu 45 50 55 60 ttc ctc cgc tac atc tcg gac tgg gac cta gac cct
ggc cgc tgc tac 304 Phe Leu Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro
Gly Arg Cys Tyr 65 70 75 cgc gtc acc tgg ttc acc tcc tgg agc ccc
tgc tac gac tgt gcc cga 352 Arg Val Thr Trp Phe Thr Ser Trp Ser Pro
Cys Tyr Asp Cys Ala Arg 80 85 90 cat gtg gcc gac ttt ctg cga ggg
aac ccc aac ctc agt ctg agg atc 400 His Val Ala Asp Phe Leu Arg Gly
Asn Pro Asn Leu Ser Leu Arg Ile 95 100 105 ttc acc gcg cgc ctc tac
ttc tgt gag gac cgc aag gct gag ccc gag 448 Phe Thr Ala Arg Leu Tyr
Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu 110 115 120 ggg ctg cgg cgg
ctg cac cgc gcc ggg gtg caa ata gcc atc atg acc 496 Gly Leu Arg Arg
Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr 125 130 135 140 ttc
aaa gat tat ttt tac tgc tgg aat act ttt gta gaa aac cat gaa 544 Phe
Lys Asp Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu 145 150
155 aga act ttc aaa gcc tgg gaa ggg ctg cat gaa aat tca gtt cgt ctc
592 Arg Thr Phe Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu
160 165 170 tcc aga cag ctt cgg cgc atc ctt ttg ccc ctg tat gag gtt
gat gac 640 Ser Arg Gln Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val
Asp Asp 175 180 185 tta cga gac gca ttt cgt act ttg gga ctt tga
tagcaacttc caggaatgtc 693 Leu Arg Asp Ala Phe Arg Thr Leu Gly Leu
190 195 acacacgatg aaatatctct gctgaagaca gtggataaaa aacagtcctt
caagtcttct 753 ctgtttttat tcttcaactc tcactttctt agagtttaca
gaaaaaatat ttatatacga 813 ctctttaaaa agatctatgt cttgaaaata
gagaaggaac acaggtctgg ccagggacgt 873 gctgcaattg gtgcagtttt
gaatgcaaca ttgtccccta ctgggaataa cagaactgca 933 ggacctggga
gcatcctaaa gtgtcaacgt ttttctatga cttttaggta ggatgagagc 993
agaaggtaga tcctaaaaag catggtgaga ggatcaaatg tttttatatc aacatccttt
1053 attatttgat tcatttgagt taacagtggt gttagtgata gatttttcta
ttcttttccc 1113 ttgacgttta ctttcaagta acacaaactc ttccatcagg
ccatgatcta taggacctcc 1173 taatgagagt atctgggtga ttgtgacccc
aaaccatctc tccaaagcat taatatccaa 1233 tcatgcgctg tatgttttaa
tcagcagaag catgttttta tgtttgtaca aaagaagatt 1293 gttatgggtg
gggatggagg tatagaccat gcatggtcac cttcaagcta ctttaataaa 1353
ggatcttaaa atgggcagga ggactgtgaa caagacaccc taataatggg ttgatgtctg
1413 aagtagcaaa tcttctggaa acgcaaactc ttttaaggaa gtccctaatt
tagaaacacc 1473 cacaaacttc acatatcata attagcaaac aattggaagg
aagttgcttg aatgttgggg 1533 agaggaaaat ctattggctc tcgtgggtct
cttcatctca gaaatgccaa tcaggtcaag 1593 gtttgctaca ttttgtatgt
gtgtgatgct tctcccaaag gtatattaac tatataagag 1653 agttgtgaca
aaacagaatg ataaagctgc gaaccgtggc acacgctcat agttctagct 1713
gcttgggagg ttgaggaggg aggatggctt gaacacaggt gttcaaggcc agcctgggca
1773 acataacaag atcctgtctc tcaaaaaaaa aaaaaaaaaa aagaaagaga
gagggccggg 1833 cgtggtggct cacgcctgta atcccagcac tttgggaggc
cgagccgggc ggatcacctg 1893 tggtcaggag tttgagacca gcctggccaa
catggcaaaa ccccgtctgt actcaaaatg 1953 caaaaattag ccaggcgtgg
tagcaggcac ctgtaatccc agctacttgg gaggctgagg 2013 caggagaatc
gcttgaaccc aggaggtgga ggttgcagta agctgagatc gtgccgttgc 2073
actccagcct gggcgacaag agcaagactc tgtctcagaa aaaaaaaaaa aaaagagaga
2133 gagagagaaa gagaacaata tttgggagag aaggatgggg aagcattgca
aggaaattgt 2193 gctttatcca acaaaatgta aggagccaat aagggatccc
tatttgtctc ttttggtgtc 2253 tatttgtccc taacaactgt ctttgacagt
gagaaaaata ttcagaataa ccatatccct 2313 gtgccgttat tacctagcaa
cccttgcaat gaagatgagc agatccacag gaaaacttga 2373 atgcacaact
gtcttatttt aatcttattg tacataagtt tgtaaaagag ttaaaaattg 2433
ttacttcatg tattcattta tattttatat tattttgcgt ctaatgattt tttattaaca
2493 tgatttcctt ttctgatata ttgaaatgga gtctcaaagc ttcataaatt
tataacttta 2553 gaaatgattc taataacaac gtatgtaatt gtaacattgc
agtaatggtg ctacgaagcc 2613 atttctcttg atttttagta aacttttatg
acagcaaatt tgcttctggc tcactttcaa 2673 tcagttaaat aaatgataaa
taattttgga agctgtgaag ataaaatacc aaataaaata 2733 atataaaagt
gatttatatg aagttaaaat aaaaaatcag tatgatggaa taaacttg 2791
<210> SEQ ID NO 40 <211> LENGTH: 198 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 40 Met
Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 1 5 10
15 Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val
20 25 30 Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe
Gly Tyr 35 40 45 Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu
Phe Leu Arg Tyr 50 55 60 Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg
Cys Tyr Arg Val Thr Trp 65 70 75 80 Phe Thr Ser Trp Ser Pro Cys Tyr
Asp Cys Ala Arg His Val Ala Asp 85 90 95 Phe Leu Arg Gly Asn Pro
Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 100 105 110 Leu Tyr Phe Cys
Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 115 120 125 Leu His
Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 130 135 140
Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 145
150 155 160 Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg
Gln Leu 165 170 175 Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp
Leu Arg Asp Ala 180 185 190 Phe Arg Thr Leu Gly Leu 195 <210>
SEQ ID NO 41 <211> LENGTH: 20 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Oligonucleotide primer sequence
<400> SEQUENCE: 41 atggacagcc tcttgatgaa 20 <210> SEQ
ID NO 42 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Oligonucleotide primer sequence <400>
SEQUENCE: 42 caggctttga aagttctttc 20 <210> SEQ ID NO 43
<211> LENGTH: 2440 <212> TYPE: DNA <213>
ORGANISM: Mus musculus <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (2413)..(2413) <223> OTHER
INFORMATION: n is a, c, g, or t <400> SEQUENCE: 43 ggcacgagca
gcactgaagc agccttgctt gaagcaagct tcctttggcc taagactttg 60
agggagtcaa gaaagtcacg ctggagaccg atatggacag ccttctgatg aagcaaaaga
120 agtttcttta ccatttcaaa aatgtccgct gggccaaggg acggcatgag
acctacctct 180 gctacgtggt gaagaggaga gatagtgcca cctcctgctc
actggacttc ggccaccttc 240 gcaacaagtc tggctgccac gtggaattgt
tgttcctacg ctacatctca gactgggacc 300 tggacccggg ccggtgttac
cgcgtcacct ggttcacctc ctggagcccg tgctatgact 360 gtgcccggca
cgtggctgag tttctgagat ggaaccctaa cctcagcctg aggattttca 420
ccgcgcgcct ctacttctgt gaagaccgca aggctgagcc tgaggggctg cggagactgc
480 accgcgctgg ggtccagatc gggatcatga ccttcaaaga ctatttttac
tgctggaata 540 catttgtaga aaatcgtgaa agaactttca aagcctggga
agggctacat gaaaattctg 600 tccggctaac cagacaactt cggcgcatcc
ttttgccctt gtacgaagtc gatgacttgc 660 gagatgcatt tcgtatgttg
ggattttgaa agcaacctcc tggaatgtca cacgtgatga 720 aatttctctg
aagagactgg atagaaaaac aacccttcaa ctacatgttt ttcttcttaa 780
gtactcactt ttataagtgt agggggaaat tatatgactt tttaaaaaat acttgagctg
840 cacaggaccg ccagagcaat gatgtaactg agcttgctgt gcaacatcgc
catctactgg 900 ggaacagcat aacttccaga ctttgggtcg tgaatgatgc
tctttttttt caacagcatg 960 gaaaagcata tggagacgac cacacagttt
gttacaccca ccctgtgttc cttgattcat 1020 ttgaattctc aggggtatca
gtgacggatt cttctattct ttccctctaa ggctcacttt 1080 caggggtcct
tttctgacaa ggtcacgggg ctgtcctaca gtctctgtct gagcaatcac 1140
aagccattct ctcaaaaaca ttaatactca ggcacatgct gtatgttttc actgtccgtc
1200 gtgtttttca catttgtatg tgaaagggct tggggtggga tttgaagaat
gcacgatcgc 1260 ctctgggtga tttcaataaa ggatcttaaa atgcagatga
ggactacgaa gaaatcactc 1320 tgaaaatgag ttcacgcctc aagaagcaaa
tcccctggaa acacagactc tttttcattt 1380 ttaatgtcat tagtttactc
acagtcttat caagaagaag agttcaaggg ttcaacccaa 1440 ttttcagatc
gcgtccctta aacatcagta attctgttaa agggatcaaa catccttatt 1500
tcttaactaa ctggtgcctt gctgtagaga aaggagcaaa gcgcccagat ccaaagtata
1560 tagttatcat agccaggaac cgctactcgt tttccattac aaatggcaaa
ttcttccccg 1620 ggctctcctc atagtgcctg agacggacca cggaggtgat
gaacctccgg attctctggc 1680 ccaacacggt ggaagctctg caagggcgca
gagacagaat gcggcagaaa ttgcccccga 1740 gtcccaactc tcctttcctt
gcgaccttgg gaacaagact taaaggagcc tgtgacttag 1800 aaacttctag
taatgggtac ctgggagtcg tttgagtatg gggcagtgat ttattctctg 1860
tgatggatgc caacacggtt aaacagaatt tttagttttt atatgtgtgt gatgctgctc
1920 ccccaaattg ttaactgtgt aagagggtgg caaaataggg aaagtggcat
tcacctatag 1980 ttccagcatt caggaagctg aggcaggagg attgtaaatt
tgaggccagt ctgagctgta 2040 aggtgagacc ctatttcaaa caacacagcc
agaattgggt tctggtaaat catacttaac 2100 aagggaaaaa tgcaagacgc
aagaccgtgg caaggaaatg acgctttgcc caacgaaatg 2160 taggaaacca
acatagactc ccagtttgtc cctctttatg tctggtctcc ctaacaacga 2220
tctttgctaa tgagaaaaat attagaaaaa aatatccctg tgcaattatc acccagtcgc
2280 cattataatg caattaaaag gcccacaaga aatcctgtat acacgaccgt
tatttattgt 2340 atgtaagttg ctgaggaaga ggagaaaaaa ataaagatca
tccattcctt cctgcaaaaa 2400 aaaaaaaaaa aanaaaaaaa aaaaaaaaaa
aaaaaaaaaa 2440 <210> SEQ ID NO 44 <211> LENGTH: 198
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 44 Met Asp Ser Leu Leu Met Lys Gln Lys Lys
Phe Leu Tyr His Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg
His Glu Thr Tyr Leu Cys Tyr Val 20 25 30 Val Lys Arg Arg Asp Ser
Ala Thr Ser Cys Ser Leu Asp Phe Gly His 35 40 45 Leu Arg Asn Lys
Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 50 55 60 Ile Ser
Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 65 70 75 80
Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Glu 85
90 95 Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala
Arg 100 105 110 Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly
Leu Arg Arg 115 120 125 Leu His Arg Ala Gly Val Gln Ile Gly Ile Met
Thr Phe Lys Asp Tyr 130 135 140 Phe Tyr Cys Trp Asn Thr Phe Val Glu
Asn Arg Glu Arg Thr Phe Lys 145 150 155 160 Ala Trp Glu Gly Leu His
Glu Asn Ser Val Arg Leu Thr Arg Gln Leu 165 170 175 Arg Arg Ile Leu
Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 180 185 190 Phe Arg
Met Leu Gly Phe 195 <210> SEQ ID NO 45 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Oligonucleotide
primer sequence <400> SEQUENCE: 45 ggattttcag gtgcagattt tcag
24 <210> SEQ ID NO 46 <211> LENGTH: 21 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Oligonucleotide primer
sequence <400> SEQUENCE: 46 actggatggt gggaagatgg a 21
<210> SEQ ID NO 47 <211> LENGTH: 19 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Oligonucleotide primer sequence
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: n = g or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: n is a, c, g, or
t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (6)..(6) <223> OTHER INFORMATION: n = a
or c <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (15)..(15) <223> OTHER
INFORMATION: n = c or g <400> SEQUENCE: 47 angtnnagct
ncagnagtc 19 <210> SEQ ID NO 48 <211> LENGTH: 19
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Oligonucleotide
primer sequence <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (8)..(8) <223>
OTHER INFORMATION: n = a or g <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (17)..(17) <223>
OTHER INFORMATION: n = g or a <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (18)..(18) <223>
OTHER INFORMATION: n = a or t <400> SEQUENCE: 48 tnccttgncc
ccagtannc 19 <210> SEQ ID NO 49 <211> LENGTH: 19
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Oligonucleotide
primer sequence <400> SEQUENCE: 49 tttcgcaacg ggtttgccg 19
<210> SEQ ID NO 50 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Oligonucleotide primer sequence
<400> SEQUENCE: 50 gtttcagagt taagccttcg 20 <210> SEQ
ID NO 51 <211> LENGTH: 13 <212> TYPE: DNA <213>
ORGANISM: Human immunoglobulin E light chain (HB134) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(6)..(6) <223> OTHER INFORMATION: n is a, c, g, or t
<400> SEQUENCE: 51 tacgtngaat aat 13 <210> SEQ ID NO 52
<211> LENGTH: 13 <212> TYPE: DNA <213> ORGANISM:
Human immunoglobulin E light chain (H36) <400> SEQUENCE: 52
tacgttgaat aat 13 <210> SEQ ID NO 53 <211> LENGTH: 63
<212> TYPE: DNA <213> ORGANISM: Human immunoglobulin E
light chain (HB134) <400> SEQUENCE: 53 gttggatgtc ctatgaatca
agggtttgag ggaagcgcct gacttctgct ggtaccagtg 60 caa 63 <210>
SEQ ID NO 54 <211> LENGTH: 63 <212> TYPE: DNA
<213> ORGANISM: Human immunoglobulin E light chain (H36)
<400> SEQUENCE: 54 gttggatgtc ctatgaatca agggtttggg
ggaagcgcct gacttctgct ggtaccagtg 60 caa 63 <210> SEQ ID NO 55
<211> LENGTH: 63 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Consensus Sequence <400> SEQUENCE: 55 gttggatgtc
ctatgaatca agggtttgrg ggaagcgcct gacttctgct ggtaccagtg 60 caa
63
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 55 <210>
SEQ ID NO 1 <211> LENGTH: 3063 <212> TYPE: DNA
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 1
ggcacgagtg gctgcttgcg gctagtggat ggtaattgcc tgcctcgcgc tagcagcaag
60 ctgctctgtt aaaagcgaaa atgaaacaat tgcctgcggc aacagttcga
ctcctttcaa 120 gttctcagat catcacttcg gtggtcagtg ttgtaaaaga
gcttattgaa aactccttgg 180 atgctggtgc cacaagcgta gatgttaaac
tggagaacta tggatttgat aaaattgagg 240 tgcgagataa cggggagggt
atcaaggctg ttgatgcacc tgtaatggca atgaagtact 300 acacctcaaa
aataaatagt catgaagatc ttgaaaattt gacaacttac ggttttcgtg 360
gagaagcctt ggggtcaatt tgttgtatag ctgaggtttt aattacaaca agaacggctg
420 ctgataattt tagcacccag tatgttttag atggcagtgg ccacatactt
tctcagaaac 480 cttcacatct tggtcaaggt acaactgtaa ctgctttaag
attatttaag aatctacctg 540 taagaaagca gttttactca actgcaaaaa
aatgtaaaga tgaaataaaa aagatccaag 600 atctcctcat gagctttggt
atccttaaac ctgacttaag gattgtcttt gtacataaca 660 aggcagttat
ttggcagaaa agcagagtat cagatcacaa gatggctctc atgtcagttc 720
tggggactgc tgttatgaac aatatggaat cctttcagta ccactctgaa gaatctcaga
780 tttatctcag tggatttctt ccaaagtgtg atgcagacca ctctttcact
agtctttcaa 840 caccagaaag aagtttcatc ttcataaaca gtcgaccagt
acatcaaaaa gatatcttaa 900 agttaatccg acatcattac aatctgaaat
gcctaaagga atctactcgt ttgtatcctg 960 ttttctttct gaaaatcgat
gttcctacag ctgatgttga tgtaaattta acaccagata 1020 aaagccaagt
attattacaa aataaggaat ctgttttaat tgctcttgaa aatctgatga 1080
cgacttgtta tggaccatta cctagtacaa attcttatga aaataataaa acagatgttt
1140 ccgcagctga catcgttctt agtaaaacag cagaaacaga tgtgcttttt
aataaagtgg 1200 aatcatctgg aaagaattat tcaaatgttg atacttcagt
cattccattc caaaatgata 1260 tgcataatga tgaatctgga aaaaacactg
atgattgttt aaatcaccag ataagtattg 1320 gtgactttgg ttatggtcat
tgtagtagtg aaatttctaa cattgataaa aacactaaga 1380 atgcatttca
ggacatttca atgagtaatg tatcatggga gaactctcag acggaatata 1440
gtaaaacttg ttttataagt tccgttaagc acacccagtc agaaaatggc aataaagacc
1500 atatagatga gagtggggaa aatgaggaag aagcaggtct tgaaaactct
tcggaaattt 1560 ctgcagatga gtggagcagg ggaaatatac ttaaaaattc
agtgggagag aatattgaac 1620 ctgtgaaaat tttagtgcct gaaaaaagtt
taccatgtaa agtaagtaat aataattatc 1680 caatccctga acaaatgaat
cttaatgaag attcatgtaa caaaaaatca aatgtaatag 1740 ataataaatc
tggaaaagtt acagcttatg atttacttag caatcgagta atcaagaaac 1800
ccatgtcagc aagtgctctt tttgttcaag atcatcgtcc tcagtttctc atagaaaatc
1860 ctaagactag tttagaggat gcaacactac aaattgaaga actgtggaag
acattgagtg 1920 aagaggaaaa actgaaatat gaagagaagg ctactaaaga
cttggaacga tacaatagtc 1980 aaatgaagag agccattgaa caggagtcac
aaatgtcact aaaagatggc agaaaaaaga 2040 taaaacccac cagcgcatgg
aatttggccc agaagcacaa gttaaaaacc tcattatcta 2100 atcaaccaaa
acttgatgaa ctccttcagt cccaaattga aaaaagaagg agtcaaaata 2160
ttaaaatggt acagatcccc ttttctatga aaaacttaaa aataaatttt aagaaacaaa
2220 acaaagttga cttagaagag aaggatgaac cttgcttgat ccacaatctc
aggtttcctg 2280 atgcatggct aatgacatcc aaaacagagg taatgttatt
aaatccatat agagtagaag 2340 aagccctgct atttaaaaga cttcttgaga
atcataaact tcctgcagag ccactggaaa 2400 agccaattat gttaacagag
agtcttttta atggatctca ttatttagac gttttatata 2460 aaatgacagc
agatgaccaa agatacagtg gatcaactta cctgtctgat cctcgtctta 2520
cagcgaatgg tttcaagata aaattgatac caggagtttc aattactgaa aattacttgg
2580 aaatagaagg aatggctaat tgtctcccat tctatggagt agcagattta
aaagaaattc 2640 ttaatgctat attaaacaga aatgcaaagg aagtttatga
atgtagacct cgcaaagtga 2700 taagttattt agagggagaa gcagtgcgtc
tatccagaca attacccatg tacttatcaa 2760 aagaggacat ccaagacatt
atctacagaa tgaagcacca gtttggaaat gaaattaaag 2820 agtgtgttca
tggtcgccca ttttttcatc atttaaccta tcttccagaa actacatgat 2880
taaatatgtt taagaagatt agttaccatt gaaattggtt ctgtcataaa acagcatgag
2940 tctggtttta aattatcttt gtattatgtg tcacatggtt attttttaaa
tgaggattca 3000 ctgacttgtt tttatattga aaaaagttcc acgtattgta
gaaaacgtaa ataaactaat 3060 aac 3063 <210> SEQ ID NO 2
<211> LENGTH: 932 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 2 Met Lys Gln Leu Pro Ala Ala
Thr Val Arg Leu Leu Ser Ser Ser Gln 1 5 10 15 Ile Ile Thr Ser Val
Val Ser Val Val Lys Glu Leu Ile Glu Asn Ser 20 25 30 Leu Asp Ala
Gly Ala Thr Ser Val Asp Val Lys Leu Glu Asn Tyr Gly 35 40 45 Phe
Asp Lys Ile Glu Val Arg Asp Asn Gly Glu Gly Ile Lys Ala Val 50 55
60 Asp Ala Pro Val Met Ala Met Lys Tyr Tyr Thr Ser Lys Ile Asn Ser
65 70 75 80 His Glu Asp Leu Glu Asn Leu Thr Thr Tyr Gly Phe Arg Gly
Glu Ala 85 90 95 Leu Gly Ser Ile Cys Cys Ile Ala Glu Val Leu Ile
Thr Thr Arg Thr 100 105 110 Ala Ala Asp Asn Phe Ser Thr Gln Tyr Val
Leu Asp Gly Ser Gly His 115 120 125 Ile Leu Ser Gln Lys Pro Ser His
Leu Gly Gln Gly Thr Thr Val Thr 130 135 140 Ala Leu Arg Leu Phe Lys
Asn Leu Pro Val Arg Lys Gln Phe Tyr Ser 145 150 155 160 Thr Ala Lys
Lys Cys Lys Asp Glu Ile Lys Lys Ile Gln Asp Leu Leu 165 170 175 Met
Ser Phe Gly Ile Leu Lys Pro Asp Leu Arg Ile Val Phe Val His 180 185
190 Asn Lys Ala Val Ile Trp Gln Lys Ser Arg Val Ser Asp His Lys Met
195 200 205 Ala Leu Met Ser Val Leu Gly Thr Ala Val Met Asn Asn Met
Glu Ser 210 215 220 Phe Gln Tyr His Ser Glu Glu Ser Gln Ile Tyr Leu
Ser Gly Phe Leu 225 230 235 240 Pro Lys Cys Asp Ala Asp His Ser Phe
Thr Ser Leu Ser Thr Pro Glu 245 250 255 Arg Ser Phe Ile Phe Ile Asn
Ser Arg Pro Val His Gln Lys Asp Ile 260 265 270 Leu Lys Leu Ile Arg
His His Tyr Asn Leu Lys Cys Leu Lys Glu Ser 275 280 285 Thr Arg Leu
Tyr Pro Val Phe Phe Leu Lys Ile Asp Val Pro Thr Ala 290 295 300 Asp
Val Asp Val Asn Leu Thr Pro Asp Lys Ser Gln Val Leu Leu Gln 305 310
315 320 Asn Lys Glu Ser Val Leu Ile Ala Leu Glu Asn Leu Met Thr Thr
Cys 325 330 335 Tyr Gly Pro Leu Pro Ser Thr Asn Ser Tyr Glu Asn Asn
Lys Thr Asp 340 345 350 Val Ser Ala Ala Asp Ile Val Leu Ser Lys Thr
Ala Glu Thr Asp Val 355 360 365 Leu Phe Asn Lys Val Glu Ser Ser Gly
Lys Asn Tyr Ser Asn Val Asp 370 375 380 Thr Ser Val Ile Pro Phe Gln
Asn Asp Met His Asn Asp Glu Ser Gly 385 390 395 400 Lys Asn Thr Asp
Asp Cys Leu Asn His Gln Ile Ser Ile Gly Asp Phe 405 410 415 Gly Tyr
Gly His Cys Ser Ser Glu Ile Ser Asn Ile Asp Lys Asn Thr 420 425 430
Lys Asn Ala Phe Gln Asp Ile Ser Met Ser Asn Val Ser Trp Glu Asn 435
440 445 Ser Gln Thr Glu Tyr Ser Lys Thr Cys Phe Ile Ser Ser Val Lys
His 450 455 460 Thr Gln Ser Glu Asn Gly Asn Lys Asp His Ile Asp Glu
Ser Gly Glu 465 470 475 480 Asn Glu Glu Glu Ala Gly Leu Glu Asn Ser
Ser Glu Ile Ser Ala Asp 485 490 495 Glu Trp Ser Arg Gly Asn Ile Leu
Lys Asn Ser Val Gly Glu Asn Ile 500 505 510 Glu Pro Val Lys Ile Leu
Val Pro Glu Lys Ser Leu Pro Cys Lys Val 515 520 525 Ser Asn Asn Asn
Tyr Pro Ile Pro Glu Gln Met Asn Leu Asn Glu Asp 530 535 540 Ser Cys
Asn Lys Lys Ser Asn Val Ile Asp Asn Lys Ser Gly Lys Val 545 550 555
560 Thr Ala Tyr Asp Leu Leu Ser Asn Arg Val Ile Lys Lys Pro Met Ser
565 570 575 Ala Ser Ala Leu Phe Val Gln Asp His Arg Pro Gln Phe Leu
Ile Glu 580 585 590 Asn Pro Lys Thr Ser Leu Glu Asp Ala Thr Leu Gln
Ile Glu Glu Leu 595 600 605 Trp Lys Thr Leu Ser Glu Glu Glu Lys Leu
Lys Tyr Glu Glu Lys Ala 610 615 620 Thr Lys Asp Leu Glu Arg Tyr Asn
Ser Gln Met Lys Arg Ala Ile Glu 625 630 635 640 Gln Glu Ser Gln Met
Ser Leu Lys Asp Gly Arg Lys Lys Ile Lys Pro 645 650 655 Thr Ser Ala
Trp Asn Leu Ala Gln Lys His Lys Leu Lys Thr Ser Leu 660 665 670
Ser Asn Gln Pro Lys Leu Asp Glu Leu Leu Gln Ser Gln Ile Glu Lys 675
680 685 Arg Arg Ser Gln Asn Ile Lys Met Val Gln Ile Pro Phe Ser Met
Lys 690 695 700 Asn Leu Lys Ile Asn Phe Lys Lys Gln Asn Lys Val Asp
Leu Glu Glu 705 710 715 720 Lys Asp Glu Pro Cys Leu Ile His Asn Leu
Arg Phe Pro Asp Ala Trp 725 730 735 Leu Met Thr Ser Lys Thr Glu Val
Met Leu Leu Asn Pro Tyr Arg Val 740 745 750 Glu Glu Ala Leu Leu Phe
Lys Arg Leu Leu Glu Asn His Lys Leu Pro 755 760 765 Ala Glu Pro Leu
Glu Lys Pro Ile Met Leu Thr Glu Ser Leu Phe Asn 770 775 780 Gly Ser
His Tyr Leu Asp Val Leu Tyr Lys Met Thr Ala Asp Asp Gln 785 790 795
800 Arg Tyr Ser Gly Ser Thr Tyr Leu Ser Asp Pro Arg Leu Thr Ala Asn
805 810 815 Gly Phe Lys Ile Lys Leu Ile Pro Gly Val Ser Ile Thr Glu
Asn Tyr 820 825 830 Leu Glu Ile Glu Gly Met Ala Asn Cys Leu Pro Phe
Tyr Gly Val Ala 835 840 845 Asp Leu Lys Glu Ile Leu Asn Ala Ile Leu
Asn Arg Asn Ala Lys Glu 850 855 860 Val Tyr Glu Cys Arg Pro Arg Lys
Val Ile Ser Tyr Leu Glu Gly Glu 865 870 875 880 Ala Val Arg Leu Ser
Arg Gln Leu Pro Met Tyr Leu Ser Lys Glu Asp 885 890 895 Ile Gln Asp
Ile Ile Tyr Arg Met Lys His Gln Phe Gly Asn Glu Ile 900 905 910 Lys
Glu Cys Val His Gly Arg Pro Phe Phe His His Leu Thr Tyr Leu 915 920
925 Pro Glu Thr Thr 930 <210> SEQ ID NO 3 <211> LENGTH:
2771 <212> TYPE: DNA <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 3 cgaggcggat cgggtgttgc atccatggag cgagctgaga
gctcgagtac agaacctgct 60 aaggccatca aacctattga tcggaagtca
gtccatcaga tttgctctgg gcaggtggta 120 ctgagtctaa gcactgcggt
aaaggagtta gtagaaaaca gtctggatgc tggtgccact 180 aatattgatc
taaagcttaa ggactatgga gtggatctta ttgaagtttc agacaatgga 240
tgtggggtag aagaagaaaa cttcgaaggc ttaactctga aacatcacac atctaagatt
300 caagagtttg ccgacctaac tcaggttgaa acttttggct ttcgggggga
agctctgagc 360 tcactttgtg cactgagcga tgtcaccatt tctacctgcc
acgcatcggc gaaggttgga 420 actcgactga tgtttgatca caatgggaaa
attatccaga aaacccccta cccccgcccc 480 agagggacca cagtcagcgt
gcagcagtta ttttccacac tacctgtgcg ccataaggaa 540 tttcaaagga
atattaagaa ggagtatgcc aaaatggtcc aggtcttaca tgcatactgt 600
atcatttcag caggcatccg tgtaagttgc accaatcagc ttggacaagg aaaacgacag
660 cctgtggtat gcacaggtgg aagccccagc ataaaggaaa atatcggctc
tgtgtttggg 720 cagaagcagt tgcaaagcct cattcctttt gttcagctgc
cccctagtga ctccgtgtgt 780 gaagagtacg gtttgagctg ttcggatgct
ctgcataatc ttttttacat ctcaggtttc 840 atttcacaat gcacgcatgg
agttggaagg agttcaacag acagacagtt tttctttatc 900 aaccggcggc
cttgtgaccc agcaaaggtc tgcagactcg tgaatgaggt ctaccacatg 960
tataatcgac accagtatcc atttgttgtt cttaacattt ctgttgattc agaatgcgtt
1020 gatatcaatg ttactccaga taaaaggcaa attttgctac aagaggaaaa
gcttttgttg 1080 gcagttttaa agacctcttt gataggaatg tttgatagtg
atgtcaacaa gctaaatgtc 1140 agtcagcagc cactgctgga tgttgaaggt
aacttaataa aaatgcatgc agcggatttg 1200 gaaaagccca tggtagaaaa
gcaggatcaa tccccttcat taaggactgg agaagaaaaa 1260 aaagacgtgt
ccatttccag actgcgagag gccttttctc ttcgtcacac aacagagaac 1320
aagcctcaca gcccaaagac tccagaacca agaaggagcc ctctaggaca gaaaaggggt
1380 atgctgtctt ctagcacttc aggtgccatc tctgacaaag gcgtcctgag
acctcagaaa 1440 gaggcagtga gttccagtca cggacccagt gaccctacgg
acagagcgga ggtggagaag 1500 gactcggggc acggcagcac ttccgtggat
tctgaggggt tcagcatccc agacacgggc 1560 agtcactgca gcagcgagta
tgcggccagc tccccagggg acaggggctc gcaggaacat 1620 gtggactctc
aggagaaagc gcctgaaact gacgactctt tttcagatgt ggactgccat 1680
tcaaaccagg aagataccgg atgtaaattt cgagttttgc ctcagccaac taatctcgca
1740 accccaaaca caaagcgttt taaaaaagaa gaaattcttt ccagttctga
catttgtcaa 1800 aagttagtaa atactcagga catgtcagcc tctcaggttg
atgtagctgt gaaaattaat 1860 aagaaagttg tgcccctgga cttttctatg
agttctttag ctaaacgaat aaagcagtta 1920 catcatgaag cacagcaaag
tgaaggggaa cagaattaca ggaagtttag ggcaaagatt 1980 tgtcctggag
aaaatcaagc agccgaagat gaactaagaa aagagataag taaaacgatg 2040
tttgcagaaa tggaaatcat tggtcagttt aacctgggat ttataataac caaactgaat
2100 gaggatatct tcatagtgga ccagcatgcc acggacgaga agtataactt
cgagatgctg 2160 cagcagcaca ccgtgctcca ggggcagagg ctcatagcac
ctcagactct caacttaact 2220 gctgttaatg aagctgttct gatagaaaat
ctggaaatat ttagaaagaa tggctttgat 2280 tttgttatcg atgaaaatgc
tccagtcact gaaagggcta aactgatttc cttgccaact 2340 agtaaaaact
ggaccttcgg accccaggac gtcgatgaac tgatcttcat gctgagcgac 2400
agccctgggg tcatgtgccg gccttcccga gtcaagcaga tgtttgcctc cagagcctgc
2460 cggaagtcgg tgatgattgg gactgctctt aacacaagcg agatgaagaa
actgatcacc 2520 cacatggggg agatggacca cccctggaac tgtccccatg
gaaggccaac catgagacac 2580 atcgccaacc tgggtgtcat ttctcagaac
tgaccgtagt cactgtatgg aataattggt 2640 tttatcgcag atttttatgt
tttgaaagac agagtcttca ctaacctttt ttgttttaaa 2700 atgaaacctg
ctacttaaaa aaaatacaca tcacacccat ttaaaagtga tcttgagaac 2760
cttttcaaac c 2771 <210> SEQ ID NO 4 <211> LENGTH: 862
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 4 Met Glu Arg Ala Glu Ser Ser Ser Thr Glu Pro
Ala Lys Ala Ile Lys 1 5 10 15 Pro Ile Asp Arg Lys Ser Val His Gln
Ile Cys Ser Gly Gln Val Val 20 25 30 Leu Ser Leu Ser Thr Ala Val
Lys Glu Leu Val Glu Asn Ser Leu Asp 35 40 45 Ala Gly Ala Thr Asn
Ile Asp Leu Lys Leu Lys Asp Tyr Gly Val Asp 50 55 60 Leu Ile Glu
Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu Asn Phe 65 70 75 80 Glu
Gly Leu Thr Leu Lys His His Thr Ser Lys Ile Gln Glu Phe Ala 85 90
95 Asp Leu Thr Gln Val Glu Thr Phe Gly Phe Arg Gly Glu Ala Leu Ser
100 105 110 Ser Leu Cys Ala Leu Ser Asp Val Thr Ile Ser Thr Cys His
Ala Ser 115 120 125 Ala Lys Val Gly Thr Arg Leu Met Phe Asp His Asn
Gly Lys Ile Ile 130 135 140 Gln Lys Thr Pro Tyr Pro Arg Pro Arg Gly
Thr Thr Val Ser Val Gln 145 150 155 160 Gln Leu Phe Ser Thr Leu Pro
Val Arg His Lys Glu Phe Gln Arg Asn 165 170 175 Ile Lys Lys Glu Tyr
Ala Lys Met Val Gln Val Leu His Ala Tyr Cys 180 185 190 Ile Ile Ser
Ala Gly Ile Arg Val Ser Cys Thr Asn Gln Leu Gly Gln 195 200 205 Gly
Lys Arg Gln Pro Val Val Cys Thr Gly Gly Ser Pro Ser Ile Lys 210 215
220 Glu Asn Ile Gly Ser Val Phe Gly Gln Lys Gln Leu Gln Ser Leu Ile
225 230 235 240 Pro Phe Val Gln Leu Pro Pro Ser Asp Ser Val Cys Glu
Glu Tyr Gly 245 250 255 Leu Ser Cys Ser Asp Ala Leu His Asn Leu Phe
Tyr Ile Ser Gly Phe 260 265 270 Ile Ser Gln Cys Thr His Gly Val Gly
Arg Ser Ser Thr Asp Arg Gln 275 280 285 Phe Phe Phe Ile Asn Arg Arg
Pro Cys Asp Pro Ala Lys Val Cys Arg 290 295 300 Leu Val Asn Glu Val
Tyr His Met Tyr Asn Arg His Gln Tyr Pro Phe 305 310 315 320 Val Val
Leu Asn Ile Ser Val Asp Ser Glu Cys Val Asp Ile Asn Val 325 330 335
Thr Pro Asp Lys Arg Gln Ile Leu Leu Gln Glu Glu Lys Leu Leu Leu 340
345 350 Ala Val Leu Lys Thr Ser Leu Ile Gly Met Phe Asp Ser Asp Val
Asn 355 360 365 Lys Leu Asn Val Ser Gln Gln Pro Leu Leu Asp Val Glu
Gly Asn Leu 370 375 380 Ile Lys Met His Ala Ala Asp Leu Glu Lys Pro
Met Val Glu Lys Gln 385 390 395 400 Asp Gln Ser Pro Ser Leu Arg Thr
Gly Glu Glu Lys Lys Asp Val Ser 405 410 415 Ile Ser Arg Leu Arg Glu
Ala Phe Ser Leu Arg His Thr Thr Glu Asn 420 425 430 Lys Pro His Ser
Pro Lys Thr Pro Glu Pro Arg Arg Ser Pro Leu Gly 435 440 445 Gln Lys
Arg Gly Met Leu Ser Ser Ser Thr Ser Gly Ala Ile Ser Asp 450 455 460
Lys Gly Val Leu Arg Pro Gln Lys Glu Ala Val Ser Ser Ser His Gly 465
470 475 480
Pro Ser Asp Pro Thr Asp Arg Ala Glu Val Glu Lys Asp Ser Gly His 485
490 495 Gly Ser Thr Ser Val Asp Ser Glu Gly Phe Ser Ile Pro Asp Thr
Gly 500 505 510 Ser His Cys Ser Ser Glu Tyr Ala Ala Ser Ser Pro Gly
Asp Arg Gly 515 520 525 Ser Gln Glu His Val Asp Ser Gln Glu Lys Ala
Pro Glu Thr Asp Asp 530 535 540 Ser Phe Ser Asp Val Asp Cys His Ser
Asn Gln Glu Asp Thr Gly Cys 545 550 555 560 Lys Phe Arg Val Leu Pro
Gln Pro Thr Asn Leu Ala Thr Pro Asn Thr 565 570 575 Lys Arg Phe Lys
Lys Glu Glu Ile Leu Ser Ser Ser Asp Ile Cys Gln 580 585 590 Lys Leu
Val Asn Thr Gln Asp Met Ser Ala Ser Gln Val Asp Val Ala 595 600 605
Val Lys Ile Asn Lys Lys Val Val Pro Leu Asp Phe Ser Met Ser Ser 610
615 620 Leu Ala Lys Arg Ile Lys Gln Leu His His Glu Ala Gln Gln Ser
Glu 625 630 635 640 Gly Glu Gln Asn Tyr Arg Lys Phe Arg Ala Lys Ile
Cys Pro Gly Glu 645 650 655 Asn Gln Ala Ala Glu Asp Glu Leu Arg Lys
Glu Ile Ser Lys Thr Met 660 665 670 Phe Ala Glu Met Glu Ile Ile Gly
Gln Phe Asn Leu Gly Phe Ile Ile 675 680 685 Thr Lys Leu Asn Glu Asp
Ile Phe Ile Val Asp Gln His Ala Thr Asp 690 695 700 Glu Lys Tyr Asn
Phe Glu Met Leu Gln Gln His Thr Val Leu Gln Gly 705 710 715 720 Gln
Arg Leu Ile Ala Pro Gln Thr Leu Asn Leu Thr Ala Val Asn Glu 725 730
735 Ala Val Leu Ile Glu Asn Leu Glu Ile Phe Arg Lys Asn Gly Phe Asp
740 745 750 Phe Val Ile Asp Glu Asn Ala Pro Val Thr Glu Arg Ala Lys
Leu Ile 755 760 765 Ser Leu Pro Thr Ser Lys Asn Trp Thr Phe Gly Pro
Gln Asp Val Asp 770 775 780 Glu Leu Ile Phe Met Leu Ser Asp Ser Pro
Gly Val Met Cys Arg Pro 785 790 795 800 Ser Arg Val Lys Gln Met Phe
Ala Ser Arg Ala Cys Arg Lys Ser Val 805 810 815 Met Ile Gly Thr Ala
Leu Asn Thr Ser Glu Met Lys Lys Leu Ile Thr 820 825 830 His Met Gly
Glu Met Asp His Pro Trp Asn Cys Pro His Gly Arg Pro 835 840 845 Thr
Met Arg His Ile Ala Asn Leu Gly Val Ile Ser Gln Asn 850 855 860
<210> SEQ ID NO 5 <211> LENGTH: 426 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 5
cgaggcggat cgggtgttgc atccatggag cgagctgaga gctcgagtac agaacctgct
60 aaggccatca aacctattga tcggaagtca gtccatcaga tttgctctgg
gcaggtggta 120 ctgagtctaa gcactgcggt aaaggagtta gtagaaaaca
gtctggatgc tggtgccact 180 aatattgatc taaagcttaa ggactatgga
gtggatctta ttgaagtttc agacaatgga 240 tgtggggtag aagaagaaaa
cttcgaaggc ttaactctga aacatcacac atctaagatt 300 caagagtttg
ccgacctaac tcaggttgaa acttttggct ttcgggggga agctctgagc 360
tcactttgtg cactgagcga tgtcaccatt tctacctgcc acgcatcggc gaaggttgga
420 acttga 426 <210> SEQ ID NO 6 <211> LENGTH: 133
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 6 Met Glu Arg Ala Glu Ser Ser Ser Thr Glu Pro
Ala Lys Ala Ile Lys 1 5 10 15 Pro Ile Asp Arg Lys Ser Val His Gln
Ile Cys Ser Gly Gln Val Val 20 25 30 Leu Ser Leu Ser Thr Ala Val
Lys Glu Leu Val Glu Asn Ser Leu Asp 35 40 45 Ala Gly Ala Thr Asn
Ile Asp Leu Lys Leu Lys Asp Tyr Gly Val Asp 50 55 60 Leu Ile Glu
Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu Asn Phe 65 70 75 80 Glu
Gly Leu Thr Leu Lys His His Thr Ser Lys Ile Gln Glu Phe Ala 85 90
95 Asp Leu Thr Gln Val Glu Thr Phe Gly Phe Arg Gly Glu Ala Leu Ser
100 105 110 Ser Leu Cys Ala Leu Ser Asp Val Thr Ile Ser Thr Cys His
Ala Ser 115 120 125 Ala Lys Val Gly Thr 130 <210> SEQ ID NO 7
<211> LENGTH: 1408 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 7 ggcgctccta
cctgcaagtg gctagtgcca agtgctgggc cgccgctcct gccgtgcatg 60
ttggggagcc agtacatgca ggtgggctcc acacggagag gggcgcagac ccggtgacag
120 ggctttacct ggtacatcgg catggcgcaa ccaaagcaag agagggtggc
gcgtgccaga 180 caccaacggt cggaaaccgc cagacaccaa cggtcggaaa
ccgccaagac accaacgctc 240 ggaaaccgcc agacaccaac gctcggaaac
cgccagacac caaggctcgg aatccacgcc 300 aggccacgac ggagggcgac
tacctccctt ctgaccctgc tgctggcgtt cggaaaaaac 360 gcagtccggt
gtgctctgat tggtccaggc tctttgacgt cacggactcg acctttgaca 420
gagccactag gcgaaaagga gagacgggaa gtattttttc cgccccgccc ggaaagggtg
480 gagcacaacg tcgaaagcag ccgttgggag cccaggaggc ggggcgcctg
tgggagccgt 540 ggagggaact ttcccagtcc ccgaggcgga tccggtgttg
catccttgga gcgagctgag 600 aactcgagta cagaacctgc taaggccatc
aaacctattg atcggaagtc agtccatcag 660 atttgctctg ggccggtggt
accgagtcta aggccgaatg cggtgaagga gttagtagaa 720 aacagtctgg
atgctggtgc cactaatgtt gatctaaagc ttaaggacta tggagtggat 780
ctcattgaag tttcaggcaa tggatgtggg gtagaagaag aaaacttcga aggctttact
840 ctgaaacatc acacatgtaa gattcaagag tttgccgacc taactcaggt
ggaaactttt 900 ggctttcggg gggaagctct gagctcactt tgtgcactga
gtgatgtcac catttctacc 960 tgccgtgtat cagcgaaggt tgggactcga
ctggtgtttg atcactatgg gaaaatcatc 1020 cagaaaaccc cctacccccg
ccccagaggg atgacagtca gcgtgaagca gttattttct 1080 acgctacctg
tgcaccataa agaatttcaa aggaatatta agaagaaacg tgcctgcttc 1140
cccttcgcct tctgccgtga ttgtcagttt cctgaggcct ccccagccat gcttcctgta
1200 cagcctgtag aactgactcc tagaagtacc ccaccccacc cctgctcctt
ggaggacaac 1260 gtgatcactg tattcagctc tgtcaagaat ggtccaggtt
cttctagatg atctgcacaa 1320 atggttcctc tcctccttcc tgatgtctgc
cattagcatt ggaataaagt tcctgctgaa 1380 aatccaaaaa aaaaaaaaaa
aaaaaaaa 1408 <210> SEQ ID NO 8 <211> LENGTH: 389
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 8 Met Ala Gln Pro Lys Gln Glu Arg Val Ala Arg
Ala Arg His Gln Arg 1 5 10 15 Ser Glu Thr Ala Arg His Gln Arg Ser
Glu Thr Ala Lys Thr Pro Thr 20 25 30 Leu Gly Asn Arg Gln Thr Pro
Thr Leu Gly Asn Arg Gln Thr Pro Arg 35 40 45 Leu Gly Ile His Ala
Arg Pro Arg Arg Arg Ala Thr Thr Ser Leu Leu 50 55 60 Thr Leu Leu
Leu Ala Phe Gly Lys Asn Ala Val Arg Cys Ala Leu Ile 65 70 75 80 Gly
Pro Gly Ser Leu Thr Ser Arg Thr Arg Pro Leu Thr Glu Pro Leu 85 90
95 Gly Glu Lys Glu Arg Arg Glu Val Phe Phe Pro Pro Arg Pro Glu Arg
100 105 110 Val Glu His Asn Val Glu Ser Ser Arg Trp Glu Pro Arg Arg
Arg Gly 115 120 125 Ala Cys Gly Ser Arg Gly Gly Asn Phe Pro Ser Pro
Arg Gly Gly Ser 130 135 140 Gly Val Ala Ser Leu Glu Arg Ala Glu Asn
Ser Ser Thr Glu Pro Ala 145 150 155 160 Lys Ala Ile Lys Pro Ile Asp
Arg Lys Ser Val His Gln Ile Cys Ser 165 170 175 Gly Pro Val Val Pro
Ser Leu Arg Pro Asn Ala Val Lys Glu Leu Val 180 185 190 Glu Asn Ser
Leu Asp Ala Gly Ala Thr Asn Val Asp Leu Lys Leu Lys 195 200 205 Asp
Tyr Gly Val Asp Leu Ile Glu Val Ser Gly Asn Gly Cys Gly Val 210 215
220 Glu Glu Glu Asn Phe Glu Gly Phe Thr Leu Lys His His Thr Cys Lys
225 230 235 240 Ile Gln Glu Phe Ala Asp Leu Thr Gln Val Glu Thr Phe
Gly Phe Arg 245 250 255 Gly Glu Ala Leu Ser Ser Leu Cys Ala Leu Ser
Asp Val Thr Ile Ser 260 265 270 Thr Cys Arg Val Ser Ala Lys Val Gly
Thr Arg Leu Val Phe Asp His 275 280 285 Tyr Gly Lys Ile Ile Gln Lys
Thr Pro Tyr Pro Arg Pro Arg Gly Met
290 295 300 Thr Val Ser Val Lys Gln Leu Phe Ser Thr Leu Pro Val His
His Lys 305 310 315 320 Glu Phe Gln Arg Asn Ile Lys Lys Lys Arg Ala
Cys Phe Pro Phe Ala 325 330 335 Phe Cys Arg Asp Cys Gln Phe Pro Glu
Ala Ser Pro Ala Met Leu Pro 340 345 350 Val Gln Pro Val Glu Leu Thr
Pro Arg Ser Thr Pro Pro His Pro Cys 355 360 365 Ser Leu Glu Asp Asn
Val Ile Thr Val Phe Ser Ser Val Lys Asn Gly 370 375 380 Pro Gly Ser
Ser Arg 385 <210> SEQ ID NO 9 <211> LENGTH: 1785
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 9 tttttagaaa ctgatgttta ttttccatca accatttttc
catgctgctt aagagaatat 60 gcaagaacag cttaagacca gtcagtggtt
gctcctaccc attcagtggc ctgagcagtg 120 gggagctgca gaccagtctt
ccgtggcagg ctgagcgctc cagtcttcag tagggaattg 180 ctgaataggc
acagagggca cctgtacacc ttcagaccag tctgcaacct caggctgagt 240
agcagtgaac tcaggagcgg gagcagtcca ttcaccctga aattcctcct tggtcactgc
300 cttctcagca gcagcctgct cttctttttc aatctcttca ggatctctgt
agaagtacag 360 atcaggcatg acctcccatg ggtgttcacg ggaaatggtg
ccacgcatgc gcagaacttc 420 ccgagccagc atccaccaca ttaaacccac
tgagtgagct cccttgttgt tgcatgggat 480 ggcaatgtcc acatagcgca
gaggagaatc tgtgttacac agcgcaatgg taggtaggtt 540 aacataagat
gcctccgtga gaggcgaagg ggcggcggga cccgggcctg gcccgtatgt 600
gtccttggcg gcctagacta ggccgtcgct gtatggtgag ccccagggag gcggatctgg
660 gcccccagaa ggacacccgc ctggatttgc cccgtagccc ggcccgggcc
cctcgggagc 720 agaacagcct tggtgaggtg gacaggaggg gacctcgcga
gcagacgcgc gcgccagcga 780 cagcagcccc gccccggcct ctcgggagcc
ggggggcaga ggctgcggag ccccaggagg 840 gtctatcagc cacagtctct
gcatgtttcc aagagcaaca ggaaatgaac acattgcagg 900 ggccagtgtc
attcaaagat gtggctgtgg atttcaccca ggaggagtgg cggcaactgg 960
accctgatga gaagatagca tacggggatg tgatgttgga gaactacagc catctagttt
1020 ctgtggggta tgattatcac caagccaaac atcatcatgg agtggaggtg
aaggaagtgg 1080 agcagggaga ggagccgtgg ataatggaag gtgaatttcc
atgtcaacat agtccagaac 1140 ctgctaaggc catcaaacct attgatcgga
agtcagtcca tcagatttgc tctgggccag 1200 tggtactgag tctaagcact
gcagtgaagg agttagtaga aaacagtctg gatgctggtg 1260 ccactaatat
tgatctaaag cttaaggact atggagtgga tctcattgaa gtttcagaca 1320
atggatgtgg ggtagaagaa gaaaactttg aaggcttaat ctctttcagc tctgaaacat
1380 cacacatgta agattcaaga gtttgccgac ctaactgaag ttgaaacttt
cggttttcag 1440 ggggaagctc tgagctcact gtgtgcactg agcgatgtca
ccatttctac ctgccacgcg 1500 ttggtgaagg ttgggactcg actggtgttt
gatcacgatg ggaaaatcat ccaggaaacc 1560 ccctaccccc accccagagg
gaccacagtc agcgtgaagc agttattttc tacgctacct 1620 gtgcgccata
aggaatttca aaggaatatt aagaagacgt gcctgcttcc ccttcgcctt 1680
ctgccgtgat tgtcagtttc ctgaggcctc cccagccatg cttcctgtac agcctgcaga
1740 actgtgagtc aattaaacct cttttcttca taaattaaaa aaaaa 1785
<210> SEQ ID NO 10 <211> LENGTH: 264 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 10 Met
Cys Pro Trp Arg Pro Arg Leu Gly Arg Arg Cys Met Val Ser Pro 1 5 10
15 Arg Glu Ala Asp Leu Gly Pro Gln Lys Asp Thr Arg Leu Asp Leu Pro
20 25 30 Arg Ser Pro Ala Arg Ala Pro Arg Glu Gln Asn Ser Leu Gly
Glu Val 35 40 45 Asp Arg Arg Gly Pro Arg Glu Gln Thr Arg Ala Pro
Ala Thr Ala Ala 50 55 60 Pro Pro Arg Pro Leu Gly Ser Arg Gly Ala
Glu Ala Ala Glu Pro Gln 65 70 75 80 Glu Gly Leu Ser Ala Thr Val Ser
Ala Cys Phe Gln Glu Gln Gln Glu 85 90 95 Met Asn Thr Leu Gln Gly
Pro Val Ser Phe Lys Asp Val Ala Val Asp 100 105 110 Phe Thr Gln Glu
Glu Trp Arg Gln Leu Asp Pro Asp Glu Lys Ile Ala 115 120 125 Tyr Gly
Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Val Gly 130 135 140
Tyr Asp Tyr His Gln Ala Lys His His His Gly Val Glu Val Lys Glu 145
150 155 160 Val Glu Gln Gly Glu Glu Pro Trp Ile Met Glu Gly Glu Phe
Pro Cys 165 170 175 Gln His Ser Pro Glu Pro Ala Lys Ala Ile Lys Pro
Ile Asp Arg Lys 180 185 190 Ser Val His Gln Ile Cys Ser Gly Pro Val
Val Leu Ser Leu Ser Thr 195 200 205 Ala Val Lys Glu Leu Val Glu Asn
Ser Leu Asp Ala Gly Ala Thr Asn 210 215 220 Ile Asp Leu Lys Leu Lys
Asp Tyr Gly Val Asp Leu Ile Glu Val Ser 225 230 235 240 Asp Asn Gly
Cys Gly Val Glu Glu Glu Asn Phe Glu Gly Leu Ile Ser 245 250 255 Phe
Ser Ser Glu Thr Ser His Met 260 <210> SEQ ID NO 11
<211> LENGTH: 2271 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 11 atgtcgttcg
tggcaggggt tattcggcgg ctggacgaga cagtggtgaa ccgcatcgcg 60
gcgggggaag ttatccagcg gccagctaat gctatcaaag agatgattga gaactgttta
120 gatgcaaaat ccacaagtat tcaagtgatt gttaaagagg gaggcctgaa
gttgattcag 180 atccaagaca atggcaccgg gatcaggaaa gaagatctgg
atattgtatg tgaaaggttc 240 actactagta aactgcagtc ctttgaggat
ttagccagta tttctaccta tggctttcga 300 ggtgaggctt tggccagcat
aagccatgtg gctcatgtta ctattacaac gaaaacagct 360 gatggaaagt
gtgcatacag agcaagttac tcagatggaa aactgaaagc ccctcctaaa 420
ccatgtgctg gcaatcaagg gacccagatc acggtggagg acctttttta caacatagcc
480 acgaggagaa aagctttaaa aaatccaagt gaagaatatg ggaaaatttt
ggaagttgtt 540 ggcaggtatt cagtacacaa tgcaggcatt agtttctcag
ttaaaaaaca aggagagaca 600 gtagctgatg ttaggacact acccaatgcc
tcaaccgtgg acaatattcg ctccatcttt 660 ggaaatgctg ttagtcgaga
actgatagaa attggatgtg aggataaaac cctagccttc 720 aaaatgaatg
gttacatatc caatgcaaac tactcagtga agaagtgcat cttcttactc 780
ttcatcaacc atcgtctggt agaatcaact tccttgagaa aagccataga aacagtgtat
840 gcagcctatt tgcccaaaaa cacacaccca ttcctgtacc tcagtttaga
aatcagtccc 900 cagaatgtgg atgttaatgt gcaccccaca aagcatgaag
ttcacttcct gcacgaggag 960 agcatcctgg agcgggtgca gcagcacatc
gagagcaagc tcctgggctc caattcctcc 1020 aggatgtact tcacccagac
tttgctacca ggacttgctg gcccctctgg ggagatggtt 1080 aaatccacaa
caagtctgac ctcgtcttct acttctggaa gtagtgataa ggtctatgcc 1140
caccagatgg ttcgtacaga ttcccgggaa cagaagcttg atgcatttct gcagcctctg
1200 agcaaacccc tgtccagtca gccccaggcc attgtcacag aggataagac
agatatttct 1260 agtggcaggg ctaggcagca agatgaggag atgcttgaac
tcccagcccc tgctgaagtg 1320 gctgccaaaa atcagagctt ggagggggat
acaacaaagg ggacttcaga aatgtcagag 1380 aagagaggac ctacttccag
caaccccaga aagagacatc gggaagattc tgatgtggaa 1440 atggtggaag
atgattcccg aaaggaaatg actgcagctt gtaccccccg gagaaggatc 1500
attaacctca ctagtgtttt gagtctccag gaagaaatta atgagcaggg acatgaggtt
1560 ctccgggaga tgttgcataa ccactccttc gtgggctgtg tgaatcctca
gtgggccttg 1620 gcacagcatc aaaccaagtt ataccttctc aacaccacca
agcttagtga agaactgttc 1680 taccagatac tcatttatga ttttgccaat
tttggtgttc tcaggttatc ggagccagca 1740 ccgctctttg accttgccat
gcttgcctta gatagtccag agagtggctg gacagaggaa 1800 gatggtccca
aagaaggact tgctgaatac attgttgagt ttctgaagaa gaaggctgag 1860
atgcttgcag actatttctc tttggaaatt gatgaggaag ggaacctgat tggattaccc
1920 cttctgattg acaactatgt gccccctttg gagggactgc ctatcttcat
tcttcgacta 1980 gccactgagg tgaattggga cgaagaaaag gaatgttttg
aaagcctcag taaagaatgc 2040 gctatgttct attccatccg gaagcagtac
atatctgagg agtcgaccct ctcaggccag 2100 cagagtgaag tgcctggctc
cattccaaac tcctggaagt ggactgtgga acacattgtc 2160 tataaagcct
tgcgctcaca cattctgcct cctaaacatt tcacagaaga tggaaatatc 2220
ctgcagcttg ctaacctgcc tgatctatac aaagtctttg agaggtgtta a 2271
<210> SEQ ID NO 12 <211> LENGTH: 756 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 12 Met
Ser Phe Val Ala Gly Val Ile Arg Arg Leu Asp Glu Thr Val Val 1 5 10
15 Asn Arg Ile Ala Ala Gly Glu Val Ile Gln Arg Pro Ala Asn Ala Ile
20 25 30 Lys Glu Met Ile Glu Asn Cys Leu Asp Ala Lys Ser Thr Ser
Ile Gln 35 40 45 Val Ile Val Lys Glu Gly Gly Leu Lys Leu Ile Gln
Ile Gln Asp Asn 50 55 60
Gly Thr Gly Ile Arg Lys Glu Asp Leu Asp Ile Val Cys Glu Arg Phe 65
70 75 80 Thr Thr Ser Lys Leu Gln Ser Phe Glu Asp Leu Ala Ser Ile
Ser Thr 85 90 95 Tyr Gly Phe Arg Gly Glu Ala Leu Ala Ser Ile Ser
His Val Ala His 100 105 110 Val Thr Ile Thr Thr Lys Thr Ala Asp Gly
Lys Cys Ala Tyr Arg Ala 115 120 125 Ser Tyr Ser Asp Gly Lys Leu Lys
Ala Pro Pro Lys Pro Cys Ala Gly 130 135 140 Asn Gln Gly Thr Gln Ile
Thr Val Glu Asp Leu Phe Tyr Asn Ile Ala 145 150 155 160 Thr Arg Arg
Lys Ala Leu Lys Asn Pro Ser Glu Glu Tyr Gly Lys Ile 165 170 175 Leu
Glu Val Val Gly Arg Tyr Ser Val His Asn Ala Gly Ile Ser Phe 180 185
190 Ser Val Lys Lys Gln Gly Glu Thr Val Ala Asp Val Arg Thr Leu Pro
195 200 205 Asn Ala Ser Thr Val Asp Asn Ile Arg Ser Ile Phe Gly Asn
Ala Val 210 215 220 Ser Arg Glu Leu Ile Glu Ile Gly Cys Glu Asp Lys
Thr Leu Ala Phe 225 230 235 240 Lys Met Asn Gly Tyr Ile Ser Asn Ala
Asn Tyr Ser Val Lys Lys Cys 245 250 255 Ile Phe Leu Leu Phe Ile Asn
His Arg Leu Val Glu Ser Thr Ser Leu 260 265 270 Arg Lys Ala Ile Glu
Thr Val Tyr Ala Ala Tyr Leu Pro Lys Asn Thr 275 280 285 His Pro Phe
Leu Tyr Leu Ser Leu Glu Ile Ser Pro Gln Asn Val Asp 290 295 300 Val
Asn Val His Pro Thr Lys His Glu Val His Phe Leu His Glu Glu 305 310
315 320 Ser Ile Leu Glu Arg Val Gln Gln His Ile Glu Ser Lys Leu Leu
Gly 325 330 335 Ser Asn Ser Ser Arg Met Tyr Phe Thr Gln Thr Leu Leu
Pro Gly Leu 340 345 350 Ala Gly Pro Ser Gly Glu Met Val Lys Ser Thr
Thr Ser Leu Thr Ser 355 360 365 Ser Ser Thr Ser Gly Ser Ser Asp Lys
Val Tyr Ala His Gln Met Val 370 375 380 Arg Thr Asp Ser Arg Glu Gln
Lys Leu Asp Ala Phe Leu Gln Pro Leu 385 390 395 400 Ser Lys Pro Leu
Ser Ser Gln Pro Gln Ala Ile Val Thr Glu Asp Lys 405 410 415 Thr Asp
Ile Ser Ser Gly Arg Ala Arg Gln Gln Asp Glu Glu Met Leu 420 425 430
Glu Leu Pro Ala Pro Ala Glu Val Ala Ala Lys Asn Gln Ser Leu Glu 435
440 445 Gly Asp Thr Thr Lys Gly Thr Ser Glu Met Ser Glu Lys Arg Gly
Pro 450 455 460 Thr Ser Ser Asn Pro Arg Lys Arg His Arg Glu Asp Ser
Asp Val Glu 465 470 475 480 Met Val Glu Asp Asp Ser Arg Lys Glu Met
Thr Ala Ala Cys Thr Pro 485 490 495 Arg Arg Arg Ile Ile Asn Leu Thr
Ser Val Leu Ser Leu Gln Glu Glu 500 505 510 Ile Asn Glu Gln Gly His
Glu Val Leu Arg Glu Met Leu His Asn His 515 520 525 Ser Phe Val Gly
Cys Val Asn Pro Gln Trp Ala Leu Ala Gln His Gln 530 535 540 Thr Lys
Leu Tyr Leu Leu Asn Thr Thr Lys Leu Ser Glu Glu Leu Phe 545 550 555
560 Tyr Gln Ile Leu Ile Tyr Asp Phe Ala Asn Phe Gly Val Leu Arg Leu
565 570 575 Ser Glu Pro Ala Pro Leu Phe Asp Leu Ala Met Leu Ala Leu
Asp Ser 580 585 590 Pro Glu Ser Gly Trp Thr Glu Glu Asp Gly Pro Lys
Glu Gly Leu Ala 595 600 605 Glu Tyr Ile Val Glu Phe Leu Lys Lys Lys
Ala Glu Met Leu Ala Asp 610 615 620 Tyr Phe Ser Leu Glu Ile Asp Glu
Glu Gly Asn Leu Ile Gly Leu Pro 625 630 635 640 Leu Leu Ile Asp Asn
Tyr Val Pro Pro Leu Glu Gly Leu Pro Ile Phe 645 650 655 Ile Leu Arg
Leu Ala Thr Glu Val Asn Trp Asp Glu Glu Lys Glu Cys 660 665 670 Phe
Glu Ser Leu Ser Lys Glu Cys Ala Met Phe Tyr Ser Ile Arg Lys 675 680
685 Gln Tyr Ile Ser Glu Glu Ser Thr Leu Ser Gly Gln Gln Ser Glu Val
690 695 700 Pro Gly Ser Ile Pro Asn Ser Trp Lys Trp Thr Val Glu His
Ile Val 705 710 715 720 Tyr Lys Ala Leu Arg Ser His Ile Leu Pro Pro
Lys His Phe Thr Glu 725 730 735 Asp Gly Asn Ile Leu Gln Leu Ala Asn
Leu Pro Asp Leu Tyr Lys Val 740 745 750 Phe Glu Arg Cys 755
<210> SEQ ID NO 13 <211> LENGTH: 4895 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 13
gtcggcgtcc gaggcggttg gtgtcggaga atttgttaag cgggactcca ggcaattatt
60 tccagtcaga gaaggaaacc agtgcctggc attctcacca tctttctacc
taccatgatc 120 aagtgcttgt cagttgaagt acaagccaaa ttgcgttctg
gtttggccat aagctccttg 180 ggccaatgtg ttgaggaact tgccctcaac
agtattgatg ctgaagcaaa atgtgtggct 240 gtcagggtga atatggaaac
cttccaagtt caagtgatag acaatggatt tgggatgggg 300 agtgatgatg
tagagaaagt gggaaatcgt tatttcacca gtaaatgcca ctcggtacag 360
gacttggaga atccaaggtt ttatggtttc cgaggagagg ccttggcaaa tattgctgac
420 atggccagtg ctgtggaaat ttcgtccaag aaaaacagga caatgaaaac
ttttgtgaaa 480 ctgtttcaga gtggaaaagc cctgaaagct tgtgaagctg
atgtgactag agcaagcgct 540 gggactactg taacagtgta taacctattt
taccagcttc ctgtaaggag gaaatgcatg 600 gaccctagac tggagtttga
gaaggttagg cagagaatag aagctctctc actcatgcac 660 ccttccattt
ctttctcttt gagaaatgat gtttctggtt ccatggttct tcagctccct 720
aaaaccaaag acgtatgttc ccgattttgt caaatttatg gattgggaaa gtcccaaaag
780 ctaagagaaa taagttttaa atataaagag tttgagctta gtggctatat
cagctctgaa 840 gcacattaca acaagaatat gcagtttttg tttgtgaaca
aaagactagt tttaaggaca 900 aagctacata aactcattga ctttttatta
aggaaagaaa gtattatatg caagccaaag 960 aatggtccca ccagtaggca
aatgaattca agtcttcggc accggtctac cccagaactc 1020 tatggcatat
atgtaattaa tgtgcagtgc caattctgtg agtatgatgt gtgcatggag 1080
ccagccaaaa ctctgattga atttcagaac tgggacactc tcttgttttg cattcaggaa
1140 ggagtgaaaa tgtttttaaa gcaagaaaaa ttatttgtgg aattatcagg
tgaggatatt 1200 aaggaattta gtgaagataa tggttttagt ttatttgatg
ctactcttca gaagcgtgtg 1260 acttccgatg agaggagcaa tttccaggaa
gcatgtaata atattttaga ttcctatgag 1320 atgtttaatt tgcagtcaaa
agctgtgaaa agaaaaacta ctgcagaaaa cgtaaacaca 1380 cagagttcta
gggattcaga agctaccaga aaaaatacaa atgatgcatt tttgtacatt 1440
tatgaatcag gtggtccagg ccatagcaaa atgacagagc catctttaca aaacaaagac
1500 agctcttgct cagaatcaaa gatgttagaa caagagacaa ttgtagcatc
agaagctggt 1560 gaaaatgaga aacataaaaa atctttcctg gaacgtagct
ctttagaaaa tccgtgtgga 1620 accagtttag aaatgttttt aagccctttt
cagacaccat gtcactttga ggagagtggg 1680 caggatctag aaatatggaa
agaaagtact actgttaatg gcatggctgc caacatcttg 1740 aaaaataata
gaattcagaa tcaaccaaag agatttaaag atgctactga agtgggatgc 1800
cagcctctgc cttttgcaac aacattatgg ggagtacata gtgctcagac agagaaagag
1860 aaaaaaaaag aatctagcaa ttgtggaaga agaaatgttt ttagttatgg
gcgagttaaa 1920 ttatgttcca ctggctttat aactcatgta gtacaaaatg
aaaaaactaa atcaactgaa 1980 acagaacatt catttaaaaa ttatgttaga
cctggtccca cacgtgccca agaaacattt 2040 ggaaatagaa cacgtcattc
agttgaaact ccagacatca aagatttagc cagcacttta 2100 agtaaagaat
ctggtcaatt gcccaacaaa aaaaattgca gaacgaatat aagttatggg 2160
ctagagaatg aacctacagc aacttataca atgttttctg cttttcagga aggtagcaaa
2220 aaatcacaaa cagattgcat attatctgat acatccccct ctttcccctg
gtatagacac 2280 gtttccaatg atagtaggaa aacagataaa ttaattggtt
tctccaaacc aatcgtccgt 2340 aagaagctaa gcttgagttc acagctagga
tctttagaga agtttaagag gcaatatggg 2400 aaggttgaaa atcctctgga
tacagaagta gaggaaagta atggagtcac taccaatctc 2460 agtcttcaag
ttgaacctga cattctgctg aaggacaaga accgcttaga gaactctgat 2520
gtttgtaaaa tcactactat ggagcatagt gattcagata gtagttgtca accagcaagc
2580 cacatccttg actcagagaa gtttccattc tccaaggatg aagattgttt
agaacaacag 2640 atgcctagtt tgagagaaag tcctatgacc ctgaaggagt
tatctctctt taatagaaaa 2700 cctttggacc ttgagaagtc atctgaatca
ctagcctcta aattatccag actgaagggt 2760 tccgaaagag aaactcaaac
aatggggatg atgagtcgtt ttaatgaact tccaaattca 2820 gattccagta
ggaaagacag caagttgtgc agtgtgttaa cacaagattt ttgtatgtta 2880
tttaacaaca agcatgaaaa aacagagaat ggtgtcatcc caacatcaga ttctgccaca
2940 caggataatt cctttaataa aaatagtaaa acacattcta acagcaatac
aacagagaac 3000 tgtgtgatat cagaaactcc tttggtattg ccctataata
attctaaagt taccggtaaa 3060 gattcagatg ttcttatcag agcctcagaa
caacagatag gaagtcttga ctctcccagt 3120 ggaatgttaa tgaatccggt
agaagatgcc acaggtgacc aaaatggaat ttgttttcag 3180 agtgaggaat
ctaaagcaag agcttgttct gaaactgaag agtcaaacac gtgttgttca 3240
gattggcagc ggcatttcga tgtagccctg ggaagaatgg tttatgtcaa caaaatgact
3300 ggactcagca cattcattgc cccaactgag gacattcagg ctgcttgtac
taaagacctg 3360
acaactgtgg ctgtggatgt tgtacttgag aatgggtctc agtacaggtg tcaacctttt
3420 agaagcgacc ttgttcttcc tttccttccg agagctcgag cagagaggac
tgtgatgaga 3480 caggataaca gagatactgt ggatgatact gttagtagcg
aatcgcttca gtctttgttc 3540 tcagaatggg acaatccagt atttgcccgt
tatccagagg ttgctgttga tgtaagcagt 3600 ggccaggctg agagcttagc
agttaaaatt cacaacatct tgtatcccta tcgtttcacc 3660 aaaggaatga
ttcattcaat gcaggttctc cagcaagtag ataacaagtt tattgcctgt 3720
ttgatgagca ctaagactga agagaatggc gaggcagatt cctacgagaa gcaacaggca
3780 caaggctctg gtcggaaaaa attactgtct tctactctaa ttcctccgct
agagataaca 3840 gtgacagagg aacaaaggag actcttatgg tgttaccaca
aaaatctgga agatctgggc 3900 cttgaatttg tatttccaga cactagtgat
tctctggtcc ttgtgggaaa agtaccacta 3960 tgttttgtgg aaagagaagc
caatgaactt cggagaggaa gatctactgt gaccaagagt 4020 attgtggagg
aatttatccg agaacaactg gagctactcc agaccaccgg aggcatccaa 4080
gggacattgc cactgactgt ccagaaggtg ttggcatccc aagcctgcca tggggccatt
4140 aagtttaatg atggcctgag cttacaggaa agttgccgcc ttattgaagc
tctgtcctca 4200 tgccagctgc cattccagtg tgctcacggg agaccttcta
tgctgccgtt agctgacata 4260 gaccacttgg aacaggaaaa acagattaaa
cccaacctca ctaaacttcg caaaatggcc 4320 caggcctggc gtctctttgg
aaaagcagag tgtgatacaa ggcagagcct gcagcagtcc 4380 atgcctccct
gtgagccacc atgagaacag aatcactggt ctaaaaggaa caaagggatg 4440
ttcactgtat gcctctgagc agagagcagc agcagcaggt accagcacgg ccctgactga
4500 atcagcccag tgtccctgag cagcttagac agcagggctc tctgtatcag
tctttcttga 4560 gcagatgatt cccctagttg agtagccaga tgaaattcaa
gcctaaagac aattcattca 4620 tttgcatcca tgggcacaga aggttgctat
atagtatcta ccttttgcta cttatttaat 4680 gataaaattt aatgacagtt
taaaaaaaaa aaaaaaaaaa attatttgaa ggggtgggtg 4740 atttttgttt
ttgtacagtt ttttttcaag cttcacattt gcgtgtatct aattcagctg 4800
atgctcaagt ccaaggggta gtctgccttc ccaggctgcc cccagggttt ctgcactggt
4860 cccctctttt cccttcagtc ttcttcactt ccctt 4895 <210> SEQ ID
NO 14 <211> LENGTH: 1429 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 14 Met Ile Lys Cys Leu
Ser Val Glu Val Gln Ala Lys Leu Arg Ser Gly 1 5 10 15 Leu Ala Ile
Ser Ser Leu Gly Gln Cys Val Glu Glu Leu Ala Leu Asn 20 25 30 Ser
Ile Asp Ala Glu Ala Lys Cys Val Ala Val Arg Val Asn Met Glu 35 40
45 Thr Phe Gln Val Gln Val Ile Asp Asn Gly Phe Gly Met Gly Ser Asp
50 55 60 Asp Val Glu Lys Val Gly Asn Arg Tyr Phe Thr Ser Lys Cys
His Ser 65 70 75 80 Val Gln Asp Leu Glu Asn Pro Arg Phe Tyr Gly Phe
Arg Gly Glu Ala 85 90 95 Leu Ala Asn Ile Ala Asp Met Ala Ser Ala
Val Glu Ile Ser Ser Lys 100 105 110 Lys Asn Arg Thr Met Lys Thr Phe
Val Lys Leu Phe Gln Ser Gly Lys 115 120 125 Ala Leu Lys Ala Cys Glu
Ala Asp Val Thr Arg Ala Ser Ala Gly Thr 130 135 140 Thr Val Thr Val
Tyr Asn Leu Phe Tyr Gln Leu Pro Val Arg Arg Lys 145 150 155 160 Cys
Met Asp Pro Arg Leu Glu Phe Glu Lys Val Arg Gln Arg Ile Glu 165 170
175 Ala Leu Ser Leu Met His Pro Ser Ile Ser Phe Ser Leu Arg Asn Asp
180 185 190 Val Ser Gly Ser Met Val Leu Gln Leu Pro Lys Thr Lys Asp
Val Cys 195 200 205 Ser Arg Phe Cys Gln Ile Tyr Gly Leu Gly Lys Ser
Gln Lys Leu Arg 210 215 220 Glu Ile Ser Phe Lys Tyr Lys Glu Phe Glu
Leu Ser Gly Tyr Ile Ser 225 230 235 240 Ser Glu Ala His Tyr Asn Lys
Asn Met Gln Phe Leu Phe Val Asn Lys 245 250 255 Arg Leu Val Leu Arg
Thr Lys Leu His Lys Leu Ile Asp Phe Leu Leu 260 265 270 Arg Lys Glu
Ser Ile Ile Cys Lys Pro Lys Asn Gly Pro Thr Ser Arg 275 280 285 Gln
Met Asn Ser Ser Leu Arg His Arg Ser Thr Pro Glu Leu Tyr Gly 290 295
300 Ile Tyr Val Ile Asn Val Gln Cys Gln Phe Cys Glu Tyr Asp Val Cys
305 310 315 320 Met Glu Pro Ala Lys Thr Leu Ile Glu Phe Gln Asn Trp
Asp Thr Leu 325 330 335 Leu Phe Cys Ile Gln Glu Gly Val Lys Met Phe
Leu Lys Gln Glu Lys 340 345 350 Leu Phe Val Glu Leu Ser Gly Glu Asp
Ile Lys Glu Phe Ser Glu Asp 355 360 365 Asn Gly Phe Ser Leu Phe Asp
Ala Thr Leu Gln Lys Arg Val Thr Ser 370 375 380 Asp Glu Arg Ser Asn
Phe Gln Glu Ala Cys Asn Asn Ile Leu Asp Ser 385 390 395 400 Tyr Glu
Met Phe Asn Leu Gln Ser Lys Ala Val Lys Arg Lys Thr Thr 405 410 415
Ala Glu Asn Val Asn Thr Gln Ser Ser Arg Asp Ser Glu Ala Thr Arg 420
425 430 Lys Asn Thr Asn Asp Ala Phe Leu Tyr Ile Tyr Glu Ser Gly Gly
Pro 435 440 445 Gly His Ser Lys Met Thr Glu Pro Ser Leu Gln Asn Lys
Asp Ser Ser 450 455 460 Cys Ser Glu Ser Lys Met Leu Glu Gln Glu Thr
Ile Val Ala Ser Glu 465 470 475 480 Ala Gly Glu Asn Glu Lys His Lys
Lys Ser Phe Leu Glu Arg Ser Ser 485 490 495 Leu Glu Asn Pro Cys Gly
Thr Ser Leu Glu Met Phe Leu Ser Pro Phe 500 505 510 Gln Thr Pro Cys
His Phe Glu Glu Ser Gly Gln Asp Leu Glu Ile Trp 515 520 525 Lys Glu
Ser Thr Thr Val Asn Gly Met Ala Ala Asn Ile Leu Lys Asn 530 535 540
Asn Arg Ile Gln Asn Gln Pro Lys Arg Phe Lys Asp Ala Thr Glu Val 545
550 555 560 Gly Cys Gln Pro Leu Pro Phe Ala Thr Thr Leu Trp Gly Val
His Ser 565 570 575 Ala Gln Thr Glu Lys Glu Lys Lys Lys Glu Ser Ser
Asn Cys Gly Arg 580 585 590 Arg Asn Val Phe Ser Tyr Gly Arg Val Lys
Leu Cys Ser Thr Gly Phe 595 600 605 Ile Thr His Val Val Gln Asn Glu
Lys Thr Lys Ser Thr Glu Thr Glu 610 615 620 His Ser Phe Lys Asn Tyr
Val Arg Pro Gly Pro Thr Arg Ala Gln Glu 625 630 635 640 Thr Phe Gly
Asn Arg Thr Arg His Ser Val Glu Thr Pro Asp Ile Lys 645 650 655 Asp
Leu Ala Ser Thr Leu Ser Lys Glu Ser Gly Gln Leu Pro Asn Lys 660 665
670 Lys Asn Cys Arg Thr Asn Ile Ser Tyr Gly Leu Glu Asn Glu Pro Thr
675 680 685 Ala Thr Tyr Thr Met Phe Ser Ala Phe Gln Glu Gly Ser Lys
Lys Ser 690 695 700 Gln Thr Asp Cys Ile Leu Ser Asp Thr Ser Pro Ser
Phe Pro Trp Tyr 705 710 715 720 Arg His Val Ser Asn Asp Ser Arg Lys
Thr Asp Lys Leu Ile Gly Phe 725 730 735 Ser Lys Pro Ile Val Arg Lys
Lys Leu Ser Leu Ser Ser Gln Leu Gly 740 745 750 Ser Leu Glu Lys Phe
Lys Arg Gln Tyr Gly Lys Val Glu Asn Pro Leu 755 760 765 Asp Thr Glu
Val Glu Glu Ser Asn Gly Val Thr Thr Asn Leu Ser Leu 770 775 780 Gln
Val Glu Pro Asp Ile Leu Leu Lys Asp Lys Asn Arg Leu Glu Asn 785 790
795 800 Ser Asp Val Cys Lys Ile Thr Thr Met Glu His Ser Asp Ser Asp
Ser 805 810 815 Ser Cys Gln Pro Ala Ser His Ile Leu Asp Ser Glu Lys
Phe Pro Phe 820 825 830 Ser Lys Asp Glu Asp Cys Leu Glu Gln Gln Met
Pro Ser Leu Arg Glu 835 840 845 Ser Pro Met Thr Leu Lys Glu Leu Ser
Leu Phe Asn Arg Lys Pro Leu 850 855 860 Asp Leu Glu Lys Ser Ser Glu
Ser Leu Ala Ser Lys Leu Ser Arg Leu 865 870 875 880 Lys Gly Ser Glu
Arg Glu Thr Gln Thr Met Gly Met Met Ser Arg Phe 885 890 895 Asn Glu
Leu Pro Asn Ser Asp Ser Ser Arg Lys Asp Ser Lys Leu Cys 900 905 910
Ser Val Leu Thr Gln Asp Phe Cys Met Leu Phe Asn Asn Lys His Glu 915
920 925 Lys Thr Glu Asn Gly Val Ile Pro Thr Ser Asp Ser Ala Thr Gln
Asp 930 935 940 Asn Ser Phe Asn Lys Asn Ser Lys Thr His Ser Asn Ser
Asn Thr Thr 945 950 955 960 Glu Asn Cys Val Ile Ser Glu Thr Pro Leu
Val Leu Pro Tyr Asn Asn 965 970 975 Ser Lys Val Thr Gly Lys Asp Ser
Asp Val Leu Ile Arg Ala Ser Glu 980 985 990 Gln Gln Ile Gly Ser Leu
Asp Ser Pro Ser Gly Met Leu Met Asn Pro 995 1000 1005 Val Glu Asp
Ala Thr Gly Asp Gln Asn Gly Ile Cys Phe Gln Ser
1010 1015 1020 Glu Glu Ser Lys Ala Arg Ala Cys Ser Glu Thr Glu Glu
Ser Asn 1025 1030 1035 Thr Cys Cys Ser Asp Trp Gln Arg His Phe Asp
Val Ala Leu Gly 1040 1045 1050 Arg Met Val Tyr Val Asn Lys Met Thr
Gly Leu Ser Thr Phe Ile 1055 1060 1065 Ala Pro Thr Glu Asp Ile Gln
Ala Ala Cys Thr Lys Asp Leu Thr 1070 1075 1080 Thr Val Ala Val Asp
Val Val Leu Glu Asn Gly Ser Gln Tyr Arg 1085 1090 1095 Cys Gln Pro
Phe Arg Ser Asp Leu Val Leu Pro Phe Leu Pro Arg 1100 1105 1110 Ala
Arg Ala Glu Arg Thr Val Met Arg Gln Asp Asn Arg Asp Thr 1115 1120
1125 Val Asp Asp Thr Val Ser Ser Glu Ser Leu Gln Ser Leu Phe Ser
1130 1135 1140 Glu Trp Asp Asn Pro Val Phe Ala Arg Tyr Pro Glu Val
Ala Val 1145 1150 1155 Asp Val Ser Ser Gly Gln Ala Glu Ser Leu Ala
Val Lys Ile His 1160 1165 1170 Asn Ile Leu Tyr Pro Tyr Arg Phe Thr
Lys Gly Met Ile His Ser 1175 1180 1185 Met Gln Val Leu Gln Gln Val
Asp Asn Lys Phe Ile Ala Cys Leu 1190 1195 1200 Met Ser Thr Lys Thr
Glu Glu Asn Gly Glu Ala Asp Ser Tyr Glu 1205 1210 1215 Lys Gln Gln
Ala Gln Gly Ser Gly Arg Lys Lys Leu Leu Ser Ser 1220 1225 1230 Thr
Leu Ile Pro Pro Leu Glu Ile Thr Val Thr Glu Glu Gln Arg 1235 1240
1245 Arg Leu Leu Trp Cys Tyr His Lys Asn Leu Glu Asp Leu Gly Leu
1250 1255 1260 Glu Phe Val Phe Pro Asp Thr Ser Asp Ser Leu Val Leu
Val Gly 1265 1270 1275 Lys Val Pro Leu Cys Phe Val Glu Arg Glu Ala
Asn Glu Leu Arg 1280 1285 1290 Arg Gly Arg Ser Thr Val Thr Lys Ser
Ile Val Glu Glu Phe Ile 1295 1300 1305 Arg Glu Gln Leu Glu Leu Leu
Gln Thr Thr Gly Gly Ile Gln Gly 1310 1315 1320 Thr Leu Pro Leu Thr
Val Gln Lys Val Leu Ala Ser Gln Ala Cys 1325 1330 1335 His Gly Ala
Ile Lys Phe Asn Asp Gly Leu Ser Leu Gln Glu Ser 1340 1345 1350 Cys
Arg Leu Ile Glu Ala Leu Ser Ser Cys Gln Leu Pro Phe Gln 1355 1360
1365 Cys Ala His Gly Arg Pro Ser Met Leu Pro Leu Ala Asp Ile Asp
1370 1375 1380 His Leu Glu Gln Glu Lys Gln Ile Lys Pro Asn Leu Thr
Lys Leu 1385 1390 1395 Arg Lys Met Ala Gln Ala Trp Arg Leu Phe Gly
Lys Ala Glu Cys 1400 1405 1410 Asp Thr Arg Gln Ser Leu Gln Gln Ser
Met Pro Pro Cys Glu Pro 1415 1420 1425 Pro <210> SEQ ID NO 15
<211> LENGTH: 3145 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 15 ggcgggaaac
agcttagtgg gtgtggggtc gcgcattttc ttcaaccagg aggtgaggag 60
gtttcgacat ggcggtgcag ccgaaggaga cgctgcagtt ggagagcgcg gccgaggtcg
120 gcttcgtgcg cttctttcag ggcatgccgg agaagccgac caccacagtg
cgccttttcg 180 accggggcga cttctatacg gcgcacggcg aggacgcgct
gctggccgcc cgggaggtgt 240 tcaagaccca gggggtgatc aagtacatgg
ggccggcagg agcaaagaat ctgcagagtg 300 ttgtgcttag taaaatgaat
tttgaatctt ttgtaaaaga tcttcttctg gttcgtcagt 360 atagagttga
agtttataag aatagagctg gaaataaggc atccaaggag aatgattggt 420
atttggcata taaggcttct cctggcaatc tctctcagtt tgaagacatt ctctttggta
480 acaatgatat gtcagcttcc attggtgttg tgggtgttaa aatgtccgca
gttgatggcc 540 agagacaggt tggagttggg tatgtggatt ccatacagag
gaaactagga ctgtgtgaat 600 tccctgataa tgatcagttc tccaatcttg
aggctctcct catccagatt ggaccaaagg 660 aatgtgtttt acccggagga
gagactgctg gagacatggg gaaactgaga cagataattc 720 aaagaggagg
aattctgatc acagaaagaa aaaaagctga cttttccaca aaagacattt 780
atcaggacct caaccggttg ttgaaaggca aaaagggaga gcagatgaat agtgctgtat
840 tgccagaaat ggagaatcag gttgcagttt catcactgtc tgcggtaatc
aagtttttag 900 aactcttatc agatgattcc aactttggac agtttgaact
gactactttt gacttcagcc 960 agtatatgaa attggatatt gcagcagtca
gagcccttaa cctttttcag ggttctgttg 1020 aagataccac tggctctcag
tctctggctg ccttgctgaa taagtgtaaa acccctcaag 1080 gacaaagact
tgttaaccag tggattaagc agcctctcat ggataagaac agaatagagg 1140
agagattgaa tttagtggaa gcttttgtag aagatgcaga attgaggcag actttacaag
1200 aagatttact tcgtcgattc ccagatctta accgacttgc caagaagttt
caaagacaag 1260 cagcaaactt acaagattgt taccgactct atcagggtat
aaatcaacta cctaatgtta 1320 tacaggctct ggaaaaacat gaaggaaaac
accagaaatt attgttggca gtttttgtga 1380 ctcctcttac tgatcttcgt
tctgacttct ccaagtttca ggaaatgata gaaacaactt 1440 tagatatgga
tcaggtggaa aaccatgaat tccttgtaaa accttcattt gatcctaatc 1500
tcagtgaatt aagagaaata atgaatgact tggaaaagaa gatgcagtca acattaataa
1560 gtgcagccag agatcttggc ttggaccctg gcaaacagat taaactggat
tccagtgcac 1620 agtttggata ttactttcgt gtaacctgta aggaagaaaa
agtccttcgt aacaataaaa 1680 actttagtac tgtagatatc cagaagaatg
gtgttaaatt taccaacagc aaattgactt 1740 ctttaaatga agagtatacc
aaaaataaaa cagaatatga agaagcccag gatgccattg 1800 ttaaagaaat
tgtcaatatt tcttcaggct atgtagaacc aatgcagaca ctcaatgatg 1860
tgttagctca gctagatgct gttgtcagct ttgctcacgt gtcaaatgga gcacctgttc
1920 catatgtacg accagccatt ttggagaaag gacaaggaag aattatatta
aaagcatcca 1980 ggcatgcttg tgttgaagtt caagatgaaa ttgcatttat
tcctaatgac gtatactttg 2040 aaaaagataa acagatgttc cacatcatta
ctggccccaa tatgggaggt aaatcaacat 2100 atattcgaca aactggggtg
atagtactca tggcccaaat tgggtgtttt gtgccatgtg 2160 agtcagcaga
agtgtccatt gtggactgca tcttagcccg agtaggggct ggtgacagtc 2220
aattgaaagg agtctccacg ttcatggctg aaatgttgga aactgcttct atcctcaggt
2280 ctgcaaccaa agattcatta ataatcatag atgaattggg aagaggaact
tctacctacg 2340 atggatttgg gttagcatgg gctatatcag aatacattgc
aacaaagatt ggtgcttttt 2400 gcatgtttgc aacccatttt catgaactta
ctgccttggc caatcagata ccaactgtta 2460 ataatctaca tgtcacagca
ctcaccactg aagagacctt aactatgctt tatcaggtga 2520 agaaaggtgt
ctgtgatcaa agttttggga ttcatgttgc agagcttgct aatttcccta 2580
agcatgtaat agagtgtgct aaacagaaag ccctggaact tgaggagttt cagtatattg
2640 gagaatcgca aggatatgat atcatggaac cagcagcaaa gaagtgctat
ctggaaagag 2700 agcaaggtga aaaaattatt caggagttcc tgtccaaggt
gaaacaaatg ccctttactg 2760 aaatgtcaga agaaaacatc acaataaagt
taaaacagct aaaagctgaa gtaatagcaa 2820 agaataatag ctttgtaaat
gaaatcattt cacgaataaa agttactacg tgaaaaatcc 2880 cagtaatgga
atgaaggtaa tattgataag ctattgtctg taatagtttt atattgtttt 2940
atattaaccc tttttccata gtgttaactg tcagtgccca tgggctatca acttaataag
3000 atatttagta atattttact ttgaggacat tttcaaagat ttttattttg
aaaaatgaga 3060 gctgtaactg aggactgttt gcaattgaca taggcaataa
taagtgatgt gctgaatttt 3120 ataaataaaa tcatgtagtt tgtgg 3145
<210> SEQ ID NO 16 <211> LENGTH: 934 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 16 Met
Ala Val Gln Pro Lys Glu Thr Leu Gln Leu Glu Ser Ala Ala Glu 1 5 10
15 Val Gly Phe Val Arg Phe Phe Gln Gly Met Pro Glu Lys Pro Thr Thr
20 25 30 Thr Val Arg Leu Phe Asp Arg Gly Asp Phe Tyr Thr Ala His
Gly Glu 35 40 45 Asp Ala Leu Leu Ala Ala Arg Glu Val Phe Lys Thr
Gln Gly Val Ile 50 55 60 Lys Tyr Met Gly Pro Ala Gly Ala Lys Asn
Leu Gln Ser Val Val Leu 65 70 75 80 Ser Lys Met Asn Phe Glu Ser Phe
Val Lys Asp Leu Leu Leu Val Arg 85 90 95 Gln Tyr Arg Val Glu Val
Tyr Lys Asn Arg Ala Gly Asn Lys Ala Ser 100 105 110 Lys Glu Asn Asp
Trp Tyr Leu Ala Tyr Lys Ala Ser Pro Gly Asn Leu 115 120 125 Ser Gln
Phe Glu Asp Ile Leu Phe Gly Asn Asn Asp Met Ser Ala Ser 130 135 140
Ile Gly Val Val Gly Val Lys Met Ser Ala Val Asp Gly Gln Arg Gln 145
150 155 160 Val Gly Val Gly Tyr Val Asp Ser Ile Gln Arg Lys Leu Gly
Leu Cys 165 170 175 Glu Phe Pro Asp Asn Asp Gln Phe Ser Asn Leu Glu
Ala Leu Leu Ile 180 185 190 Gln Ile Gly Pro Lys Glu Cys Val Leu Pro
Gly Gly Glu Thr Ala Gly 195 200 205 Asp Met Gly Lys Leu Arg Gln Ile
Ile Gln Arg Gly Gly Ile Leu Ile 210 215 220 Thr Glu Arg Lys Lys Ala
Asp Phe Ser Thr Lys Asp Ile Tyr Gln Asp 225 230 235 240 Leu Asn Arg
Leu Leu Lys Gly Lys Lys Gly Glu Gln Met Asn Ser Ala 245 250 255
Val Leu Pro Glu Met Glu Asn Gln Val Ala Val Ser Ser Leu Ser Ala 260
265 270 Val Ile Lys Phe Leu Glu Leu Leu Ser Asp Asp Ser Asn Phe Gly
Gln 275 280 285 Phe Glu Leu Thr Thr Phe Asp Phe Ser Gln Tyr Met Lys
Leu Asp Ile 290 295 300 Ala Ala Val Arg Ala Leu Asn Leu Phe Gln Gly
Ser Val Glu Asp Thr 305 310 315 320 Thr Gly Ser Gln Ser Leu Ala Ala
Leu Leu Asn Lys Cys Lys Thr Pro 325 330 335 Gln Gly Gln Arg Leu Val
Asn Gln Trp Ile Lys Gln Pro Leu Met Asp 340 345 350 Lys Asn Arg Ile
Glu Glu Arg Leu Asn Leu Val Glu Ala Phe Val Glu 355 360 365 Asp Ala
Glu Leu Arg Gln Thr Leu Gln Glu Asp Leu Leu Arg Arg Phe 370 375 380
Pro Asp Leu Asn Arg Leu Ala Lys Lys Phe Gln Arg Gln Ala Ala Asn 385
390 395 400 Leu Gln Asp Cys Tyr Arg Leu Tyr Gln Gly Ile Asn Gln Leu
Pro Asn 405 410 415 Val Ile Gln Ala Leu Glu Lys His Glu Gly Lys His
Gln Lys Leu Leu 420 425 430 Leu Ala Val Phe Val Thr Pro Leu Thr Asp
Leu Arg Ser Asp Phe Ser 435 440 445 Lys Phe Gln Glu Met Ile Glu Thr
Thr Leu Asp Met Asp Gln Val Glu 450 455 460 Asn His Glu Phe Leu Val
Lys Pro Ser Phe Asp Pro Asn Leu Ser Glu 465 470 475 480 Leu Arg Glu
Ile Met Asn Asp Leu Glu Lys Lys Met Gln Ser Thr Leu 485 490 495 Ile
Ser Ala Ala Arg Asp Leu Gly Leu Asp Pro Gly Lys Gln Ile Lys 500 505
510 Leu Asp Ser Ser Ala Gln Phe Gly Tyr Tyr Phe Arg Val Thr Cys Lys
515 520 525 Glu Glu Lys Val Leu Arg Asn Asn Lys Asn Phe Ser Thr Val
Asp Ile 530 535 540 Gln Lys Asn Gly Val Lys Phe Thr Asn Ser Lys Leu
Thr Ser Leu Asn 545 550 555 560 Glu Glu Tyr Thr Lys Asn Lys Thr Glu
Tyr Glu Glu Ala Gln Asp Ala 565 570 575 Ile Val Lys Glu Ile Val Asn
Ile Ser Ser Gly Tyr Val Glu Pro Met 580 585 590 Gln Thr Leu Asn Asp
Val Leu Ala Gln Leu Asp Ala Val Val Ser Phe 595 600 605 Ala His Val
Ser Asn Gly Ala Pro Val Pro Tyr Val Arg Pro Ala Ile 610 615 620 Leu
Glu Lys Gly Gln Gly Arg Ile Ile Leu Lys Ala Ser Arg His Ala 625 630
635 640 Cys Val Glu Val Gln Asp Glu Ile Ala Phe Ile Pro Asn Asp Val
Tyr 645 650 655 Phe Glu Lys Asp Lys Gln Met Phe His Ile Ile Thr Gly
Pro Asn Met 660 665 670 Gly Gly Lys Ser Thr Tyr Ile Arg Gln Thr Gly
Val Ile Val Leu Met 675 680 685 Ala Gln Ile Gly Cys Phe Val Pro Cys
Glu Ser Ala Glu Val Ser Ile 690 695 700 Val Asp Cys Ile Leu Ala Arg
Val Gly Ala Gly Asp Ser Gln Leu Lys 705 710 715 720 Gly Val Ser Thr
Phe Met Ala Glu Met Leu Glu Thr Ala Ser Ile Leu 725 730 735 Arg Ser
Ala Thr Lys Asp Ser Leu Ile Ile Ile Asp Glu Leu Gly Arg 740 745 750
Gly Thr Ser Thr Tyr Asp Gly Phe Gly Leu Ala Trp Ala Ile Ser Glu 755
760 765 Tyr Ile Ala Thr Lys Ile Gly Ala Phe Cys Met Phe Ala Thr His
Phe 770 775 780 His Glu Leu Thr Ala Leu Ala Asn Gln Ile Pro Thr Val
Asn Asn Leu 785 790 795 800 His Val Thr Ala Leu Thr Thr Glu Glu Thr
Leu Thr Met Leu Tyr Gln 805 810 815 Val Lys Lys Gly Val Cys Asp Gln
Ser Phe Gly Ile His Val Ala Glu 820 825 830 Leu Ala Asn Phe Pro Lys
His Val Ile Glu Cys Ala Lys Gln Lys Ala 835 840 845 Leu Glu Leu Glu
Glu Phe Gln Tyr Ile Gly Glu Ser Gln Gly Tyr Asp 850 855 860 Ile Met
Glu Pro Ala Ala Lys Lys Cys Tyr Leu Glu Arg Glu Gln Gly 865 870 875
880 Glu Lys Ile Ile Gln Glu Phe Leu Ser Lys Val Lys Gln Met Pro Phe
885 890 895 Thr Glu Met Ser Glu Glu Asn Ile Thr Ile Lys Leu Lys Gln
Leu Lys 900 905 910 Ala Glu Val Ile Ala Lys Asn Asn Ser Phe Val Asn
Glu Ile Ile Ser 915 920 925 Arg Ile Lys Val Thr Thr 930 <210>
SEQ ID NO 17 <211> LENGTH: 4374 <212> TYPE: DNA
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 17
gggcacgagc cctgccatgt ctcgccggaa gcctgcgtcg ggcggcctcg ctgcctccag
60 ctcagcccct gcgaggcaag cggttttgag ccgattcttc cagtctacgg
gaagcctgaa 120 atccacctcc tcctccacag gtgcagccga ccaggtggac
cctggcgctg cagcggccgc 180 agcgccccca gcgcccgcct tcccgcccca
gctgccgccg cacgtagcta cagaaattga 240 cagaagaaag aagagaccat
tggaaaatga tgggcctgtt aaaaagaaag taaagaaagt 300 ccaacaaaag
gaaggaggaa gtgatctggg aatgtctggc aactctgagc caaagaaatg 360
tctgaggacc aggaatgttt caaagtctct ggaaaaattg aaagaattct gctgcgattc
420 tgcccttcct caaagtagag tccagacaga atctctgcag gagagatttg
cagttctgcc 480 aaaatgtact gattttgatg atatcagtct tctacacgca
aagaatgcag tttcttctga 540 agattcgaaa cgtcaaatta atcaaaagga
cacaacactt tttgatctca gtcagtttgg 600 atcatcaaat acaagtcatg
aaaatttaca gaaaactgct tccaaatcag ctaacaaacg 660 gtccaaaagc
atctatacgc cgctagaatt acaatacata gaaatgaagc agcagcacaa 720
agatgcagtt ttgtgtgtgg aatgtggata taagtataga ttctttgggg aagatgcaga
780 gattgcagcc cgagagctca atatttattg ccatttagat cacaacttta
tgacagcaag 840 tatacctact cacagactgt ttgttcatgt acgccgcctg
gtggcaaaag gatataaggt 900 gggagttgtg aagcaaactg aaactgcagc
attaaaggcc attggagaca acagaagttc 960 actcttttcc cggaaattga
ctgcccttta tacaaaatct acacttattg gagaagatgt 1020 gaatccccta
atcaagctgg atgatgctgt aaatgttgat gagataatga ctgatacttc 1080
taccagctat cttctgtgca tctctgaaaa taaggaaaat gttagggaca aaaaaaaggg
1140 caacattttt attggcattg tgggagtgca gcctgccaca ggcgaggttg
tgtttgatag 1200 tttccaggac tctgcttctc gttcagagct agaaacccgg
atgtcaagcc tgcagccagt 1260 agagctgctg cttccttcgg ccttgtccga
gcaaacagag gcgctcatcc acagagccac 1320 atctgttagt gtgcaggatg
acagaattcg agtcgaaagg atggataaca tttattttga 1380 atacagccat
gctttccagg cagttacaga gttttatgca aaagatacag ttgacatcaa 1440
aggttctcaa attatttctg gcattgttaa cttagagaag cctgtgattt gctctttggc
1500 tgccatcata aaatacctca aagaattcaa cttggaaaag atgctctcca
aacctgagaa 1560 ttttaaacag ctatcaagta aaatggaatt tatgacaatt
aatggaacaa cattaaggaa 1620 tctggaaatc ctacagaatc agactgatat
gaaaaccaaa ggaagtttgc tgtgggtttt 1680 agaccacact aaaacttcat
ttgggagacg gaagttaaag aagtgggtga cccagccact 1740 ccttaaatta
agggaaataa atgcccggct tgatgctgta tcggaagttc tccattcaga 1800
atctagtgtg tttggtcaga tagaaaatca tctacgtaaa ttgcccgaca tagagagggg
1860 actctgtagc atttatcaca aaaaatgttc tacccaagag ttcttcttga
ttgtcaaaac 1920 tttatatcac ctaaagtcag aatttcaagc aataatacct
gctgttaatt cccacattca 1980 gtcagacttg ctccggaccg ttattttaga
aattcctgaa ctcctcagtc cagtggagca 2040 ttacttaaag atactcaatg
aacaagctgc caaagttggg gataaaactg aattatttaa 2100 agacctttct
gacttccctt taataaaaaa gaggaaggat gaaattcaag gtgttattga 2160
cgagatccga atgcatttgc aagaaatacg aaaaatacta aaaaatcctt ctgcacaata
2220 tgtgacagta tcaggacagg agtttatgat agaaataaag aactctgctg
tatcttgtat 2280 accaactgat tgggtaaagg ttggaagcac aaaagctgtg
agccgctttc actctccttt 2340 tattgtagaa aattacagac atctgaatca
gctccgggag cagctagtcc ttgactgcag 2400 tgctgaatgg cttgattttc
tagagaaatt cagtgaacat tatcactcct tgtgtaaagc 2460 agtgcatcac
ctagcaactg ttgactgcat tttctccctg gccaaggtcg ctaagcaagg 2520
agattactgc agaccaactg tacaagaaga aagaaaaatt gtaataaaaa atggaaggca
2580 ccctgtgatt gatgtgttgc tgggagaaca ggatcaatat gtcccaaata
atacagattt 2640 atcagaggac tcagagagag taatgataat taccggacca
aacatgggtg gaaagagctc 2700 ctacataaaa caagttgcat tgattaccat
catggctcag attggctcct atgttcctgc 2760 agaagaagcg acaattggga
ttgtggatgg cattttcaca aggatgggtg ctgcagacaa 2820 tatatataaa
ggacggagta catttatgga agaactgact gacacagcag aaataatcag 2880
aaaagcaaca tcacagtcct tggttatctt ggatgaacta ggaagaggga cgagcactca
2940 tgatggaatt gccattgcct atgctacact tgagtatttc atcagagatg
tgaaatcctt 3000 aaccctgttt gtcacccatt atccgccagt ttgtgaacta
gaaaaaaatt actcacacca 3060 ggtggggaat taccacatgg gattcttggt
cagtgaggat gaaagcaaac tggatccagg 3120 cgcagcagaa caagtccctg
attttgtcac cttcctttac caaataacta gaggaattgc 3180 agcaaggagt
tatggattaa atgtggctaa actagcagat gttcctggag aaattttgaa 3240
gaaagcagct cacaagtcaa aagagctgga aggattaata aatacgaaaa gaaagagact
3300 caagtatttt gcaaagttat ggacgatgca taatgcacaa gacctgcaga
agtggacaga 3360 ggagttcaac atggaagaaa cacagacttc tcttcttcat
taaaatgaag actacatttg 3420 tgaacaaaaa atggagaatt aaaaatacca
actgtacaaa ataactctcc agtaacagcc 3480 tatctttgtg tgacatgtga
gcataaaatt atgaccatgg tatattccta ttggaaacag 3540 agaggttttt
ctgaagacag tctttttcaa gtttctgtct tcctaacttt tctacgtata 3600
aacactcttg aatagacttc cactttgtaa ttagaaaatt ttatggacag taagtccagt
3660
aaagccttaa gtggcagaat ataattccca agcttttgga gggtgatata aaaatttact
3720 tgatattttt atttgtttca gttcagataa ttggcaactg ggtgaatctg
gcaggaatct 3780 atccattgaa ctaaaataat tttattatgc aaccagttta
tccaccaaga acataagaat 3840 tttttataag tagaaagaat tggccaggca
tggtggctca tgcctgtaat cccagcactt 3900 tgggaggcca aggtaggcag
atcacctgag gtcaggagtt caagaccagc ctggccaaca 3960 tggcaaaacc
ccatctttac taaaaatata aagtacatct ctactaaaaa tacgaaaaaa 4020
ttagctgggc atggtggcgc acacctgtag tcccagctac tccggaggct gaggcaggag
4080 aatctcttga acctgggagg cggaggttgc aatgagccga gatcacgtca
ctgcactcca 4140 gcttgggcaa cagagcaaga ctccatctca aaaaagaaaa
aagaaaagaa atagaattat 4200 caagctttta aaaactagag cacagaagga
ataaggtcat gaaatttaaa aggttaaata 4260 ttgtcatagg attaagcagt
ttaaagattg ttggatgaaa ttatttgtca ttcattcaag 4320 taataaatat
ttaatgaata cttgctataa aaaaaaaaaa aaaaaaaaaa aaaa 4374 <210>
SEQ ID NO 18 <211> LENGTH: 1128 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 18 Met Ser
Arg Arg Lys Pro Ala Ser Gly Gly Leu Ala Ala Ser Ser Ser 1 5 10 15
Ala Pro Ala Arg Gln Ala Val Leu Ser Arg Phe Phe Gln Ser Thr Gly 20
25 30 Ser Leu Lys Ser Thr Ser Ser Ser Thr Gly Ala Ala Asp Gln Val
Asp 35 40 45 Pro Gly Ala Ala Ala Ala Ala Ala Pro Pro Ala Pro Ala
Phe Pro Pro 50 55 60 Gln Leu Pro Pro His Val Ala Thr Glu Ile Asp
Arg Arg Lys Lys Arg 65 70 75 80 Pro Leu Glu Asn Asp Gly Pro Val Lys
Lys Lys Val Lys Lys Val Gln 85 90 95 Gln Lys Glu Gly Gly Ser Asp
Leu Gly Met Ser Gly Asn Ser Glu Pro 100 105 110 Lys Lys Cys Leu Arg
Thr Arg Asn Val Ser Lys Ser Leu Glu Lys Leu 115 120 125 Lys Glu Phe
Cys Cys Asp Ser Ala Leu Pro Gln Ser Arg Val Gln Thr 130 135 140 Glu
Ser Leu Gln Glu Arg Phe Ala Val Leu Pro Lys Cys Thr Asp Phe 145 150
155 160 Asp Asp Ile Ser Leu Leu His Ala Lys Asn Ala Val Ser Ser Glu
Asp 165 170 175 Ser Lys Arg Gln Ile Asn Gln Lys Asp Thr Thr Leu Phe
Asp Leu Ser 180 185 190 Gln Phe Gly Ser Ser Asn Thr Ser His Glu Asn
Leu Gln Lys Thr Ala 195 200 205 Ser Lys Ser Ala Asn Lys Arg Ser Lys
Ser Ile Tyr Thr Pro Leu Glu 210 215 220 Leu Gln Tyr Ile Glu Met Lys
Gln Gln His Lys Asp Ala Val Leu Cys 225 230 235 240 Val Glu Cys Gly
Tyr Lys Tyr Arg Phe Phe Gly Glu Asp Ala Glu Ile 245 250 255 Ala Ala
Arg Glu Leu Asn Ile Tyr Cys His Leu Asp His Asn Phe Met 260 265 270
Thr Ala Ser Ile Pro Thr His Arg Leu Phe Val His Val Arg Arg Leu 275
280 285 Val Ala Lys Gly Tyr Lys Val Gly Val Val Lys Gln Thr Glu Thr
Ala 290 295 300 Ala Leu Lys Ala Ile Gly Asp Asn Arg Ser Ser Leu Phe
Ser Arg Lys 305 310 315 320 Leu Thr Ala Leu Tyr Thr Lys Ser Thr Leu
Ile Gly Glu Asp Val Asn 325 330 335 Pro Leu Ile Lys Leu Asp Asp Ala
Val Asn Val Asp Glu Ile Met Thr 340 345 350 Asp Thr Ser Thr Ser Tyr
Leu Leu Cys Ile Ser Glu Asn Lys Glu Asn 355 360 365 Val Arg Asp Lys
Lys Lys Gly Asn Ile Phe Ile Gly Ile Val Gly Val 370 375 380 Gln Pro
Ala Thr Gly Glu Val Val Phe Asp Ser Phe Gln Asp Ser Ala 385 390 395
400 Ser Arg Ser Glu Leu Glu Thr Arg Met Ser Ser Leu Gln Pro Val Glu
405 410 415 Leu Leu Leu Pro Ser Ala Leu Ser Glu Gln Thr Glu Ala Leu
Ile His 420 425 430 Arg Ala Thr Ser Val Ser Val Gln Asp Asp Arg Ile
Arg Val Glu Arg 435 440 445 Met Asp Asn Ile Tyr Phe Glu Tyr Ser His
Ala Phe Gln Ala Val Thr 450 455 460 Glu Phe Tyr Ala Lys Asp Thr Val
Asp Ile Lys Gly Ser Gln Ile Ile 465 470 475 480 Ser Gly Ile Val Asn
Leu Glu Lys Pro Val Ile Cys Ser Leu Ala Ala 485 490 495 Ile Ile Lys
Tyr Leu Lys Glu Phe Asn Leu Glu Lys Met Leu Ser Lys 500 505 510 Pro
Glu Asn Phe Lys Gln Leu Ser Ser Lys Met Glu Phe Met Thr Ile 515 520
525 Asn Gly Thr Thr Leu Arg Asn Leu Glu Ile Leu Gln Asn Gln Thr Asp
530 535 540 Met Lys Thr Lys Gly Ser Leu Leu Trp Val Leu Asp His Thr
Lys Thr 545 550 555 560 Ser Phe Gly Arg Arg Lys Leu Lys Lys Trp Val
Thr Gln Pro Leu Leu 565 570 575 Lys Leu Arg Glu Ile Asn Ala Arg Leu
Asp Ala Val Ser Glu Val Leu 580 585 590 His Ser Glu Ser Ser Val Phe
Gly Gln Ile Glu Asn His Leu Arg Lys 595 600 605 Leu Pro Asp Ile Glu
Arg Gly Leu Cys Ser Ile Tyr His Lys Lys Cys 610 615 620 Ser Thr Gln
Glu Phe Phe Leu Ile Val Lys Thr Leu Tyr His Leu Lys 625 630 635 640
Ser Glu Phe Gln Ala Ile Ile Pro Ala Val Asn Ser His Ile Gln Ser 645
650 655 Asp Leu Leu Arg Thr Val Ile Leu Glu Ile Pro Glu Leu Leu Ser
Pro 660 665 670 Val Glu His Tyr Leu Lys Ile Leu Asn Glu Gln Ala Ala
Lys Val Gly 675 680 685 Asp Lys Thr Glu Leu Phe Lys Asp Leu Ser Asp
Phe Pro Leu Ile Lys 690 695 700 Lys Arg Lys Asp Glu Ile Gln Gly Val
Ile Asp Glu Ile Arg Met His 705 710 715 720 Leu Gln Glu Ile Arg Lys
Ile Leu Lys Asn Pro Ser Ala Gln Tyr Val 725 730 735 Thr Val Ser Gly
Gln Glu Phe Met Ile Glu Ile Lys Asn Ser Ala Val 740 745 750 Ser Cys
Ile Pro Thr Asp Trp Val Lys Val Gly Ser Thr Lys Ala Val 755 760 765
Ser Arg Phe His Ser Pro Phe Ile Val Glu Asn Tyr Arg His Leu Asn 770
775 780 Gln Leu Arg Glu Gln Leu Val Leu Asp Cys Ser Ala Glu Trp Leu
Asp 785 790 795 800 Phe Leu Glu Lys Phe Ser Glu His Tyr His Ser Leu
Cys Lys Ala Val 805 810 815 His His Leu Ala Thr Val Asp Cys Ile Phe
Ser Leu Ala Lys Val Ala 820 825 830 Lys Gln Gly Asp Tyr Cys Arg Pro
Thr Val Gln Glu Glu Arg Lys Ile 835 840 845 Val Ile Lys Asn Gly Arg
His Pro Val Ile Asp Val Leu Leu Gly Glu 850 855 860 Gln Asp Gln Tyr
Val Pro Asn Asn Thr Asp Leu Ser Glu Asp Ser Glu 865 870 875 880 Arg
Val Met Ile Ile Thr Gly Pro Asn Met Gly Gly Lys Ser Ser Tyr 885 890
895 Ile Lys Gln Val Ala Leu Ile Thr Ile Met Ala Gln Ile Gly Ser Tyr
900 905 910 Val Pro Ala Glu Glu Ala Thr Ile Gly Ile Val Asp Gly Ile
Phe Thr 915 920 925 Arg Met Gly Ala Ala Asp Asn Ile Tyr Lys Gly Arg
Ser Thr Phe Met 930 935 940 Glu Glu Leu Thr Asp Thr Ala Glu Ile Ile
Arg Lys Ala Thr Ser Gln 945 950 955 960 Ser Leu Val Ile Leu Asp Glu
Leu Gly Arg Gly Thr Ser Thr His Asp 965 970 975 Gly Ile Ala Ile Ala
Tyr Ala Thr Leu Glu Tyr Phe Ile Arg Asp Val 980 985 990 Lys Ser Leu
Thr Leu Phe Val Thr His Tyr Pro Pro Val Cys Glu Leu 995 1000 1005
Glu Lys Asn Tyr Ser His Gln Val Gly Asn Tyr His Met Gly Phe 1010
1015 1020 Leu Val Ser Glu Asp Glu Ser Lys Leu Asp Pro Gly Ala Ala
Glu 1025 1030 1035 Gln Val Pro Asp Phe Val Thr Phe Leu Tyr Gln Ile
Thr Arg Gly 1040 1045 1050 Ile Ala Ala Arg Ser Tyr Gly Leu Asn Val
Ala Lys Leu Ala Asp 1055 1060 1065 Val Pro Gly Glu Ile Leu Lys Lys
Ala Ala His Lys Ser Lys Glu 1070 1075 1080 Leu Glu Gly Leu Ile Asn
Thr Lys Arg Lys Arg Leu Lys Tyr Phe 1085 1090 1095 Ala Lys Leu Trp
Thr Met His Asn Ala Gln Asp Leu Gln Lys Trp 1100 1105 1110 Thr Glu
Glu Phe Asn Met Glu Glu Thr Gln Thr Ser Leu Leu His 1115 1120 1125
<210> SEQ ID NO 19 <211> LENGTH: 3095 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 19
cagaaacctc atacttctcg ggtcagggaa ggtttgggag gatgctgagg cctgagatct
60 catcaacctc gccttctgcc ccggcggttt cccccgtcgt cggagaaacc
cgctcacctc 120 agggtccccg ctacaatttc ggactccagg agactccaca
gagccgccct tcggtccagg 180 tggtctctgc atccacctgt cctggcacgt
caggagctgc gggcgaccgg agcagcagca 240 gcagcagcct tccctgcccc
gcgccaaact cccggccagc tcaaggttca tactttggaa 300
acaaaagagc ttatgcagaa aacacagttg catcaaattt tacttttggt gcaagctcat
360 cttctgcacg agatactaat tatcctcaaa cacttaaaac tccattgtct
actggaaatc 420 ctcagagatc aggttataag agctggacac cacaagtggg
atattcagct tcatcctcat 480 ctgcgatttc tgcacactcc ccatcagtta
ttgtagctgt tgtagaaggg agaggacttg 540 ccagaggtga aataggaatg
gcaagtattg atttaaaaaa cccccaaatt atactatccc 600 agtttgcaga
caacacaaca tatgcaaagg tgatcactaa acttaaaatt ttatcacctt 660
tggaaataat aatgtcaaat actgcttgtg ctgtggggaa ttccaccaag ttgttcactc
720 tgatcacaga aaatttcaag aatgttaatt tcactactat ccaaaggaaa
tacttcaatg 780 aaacaaaagg attagagtac attgaacagt tatgcatagc
agaattcagc actgtcctaa 840 tggaggttca gtccaagtat tactgccttg
cagctgttgc agctttgtta aaatatgttg 900 aatttattca aaattcagtt
tatgcaccaa aatcactgaa gatttgtttc cagggtagtg 960 aacagacagc
catgatagat tcatcatcag cccaaaacct tgaattgtta attaataatc 1020
aagactatag gaataatcac actctctttg gtgttctaaa ttatactaag actcctggag
1080 ggagtagacg acttcgttct aatatattag agcctctagt tgatattgaa
accattaaca 1140 tgcgcttaga ttgtgttcaa gaactacttc aagatgagga
actatttttt ggacttcaat 1200 cagttatatc aagatttctt gatacagagc
agcttctttc tgttttagtc caaattccag 1260 agcaagacac ggtcaatgct
gctgaatcaa agataacaaa tttaatatac ttaaaacata 1320 ccttggaact
tgtggatcct ttaaagattg ctatgaagaa ctgtaacaca cctttattaa 1380
gagcttacta tggttccttg gaagacaaga ggtttggaat catacttgaa aagattaaaa
1440 cagtaattaa tgatgatgca agatacatga aaggatgcct aaacatgagg
actcagaagt 1500 gctatgcagt gaggtctaac ataaatgaat ttcttgacat
agcaagaaga acatacacag 1560 agattgtaga tgacatagca ggaatgatat
cacaacttgg agaaaaatat agtctacctt 1620 taaggacaag tcttagctct
gttcgaggat ttttcatcca gatgactaca gattgtatag 1680 ccctacctag
tgatcaactt ccttcagaat ttattaagat ttctaaagtg aaaaattctt 1740
acagctttac atcagcagat ttaattaaaa tgaatgaaag atgccaagaa tctttgagag
1800 aaatctatca catgacttat atgatagtgt gcaaactgct tagtgagatt
tatgaacata 1860 ttcattgctt atataaacta tctgacactg tgtcaatgct
ggatatgcta ctgtcatttg 1920 ctcatgcctg cactctttct gactatgttc
gaccagaatt tactgatact ttagcaatca 1980 aacagggatg gcatcctatt
cttgaaaaaa tatctgcgga aaaacctatt gccaacaata 2040 cctatgttac
agaagggagt aattttttga tcataactgg accaaacatg agtggaaaat 2100
ccacatattt aaaacagatt gctctttgtc agattatggc ccagattgga tcatatgttc
2160 cagcagaata ttcttccttt agaattgcta aacagatttt tacaagaatt
agtactgatg 2220 atgatatcga aacaaattca tcaacattta tgaaagaaat
gaaagagata gcatatattc 2280 tacataatgc taatgacaaa tcgctcatat
taattgatga acttggcaga ggtactaata 2340 cggaagaagg tattggcatt
tgttatgctg tttgtgaata tctactgagc ttaaaggcat 2400 ttacactgtt
tgctacacat ttcctggaac tatgccatat tgatgccctg tatcctaatg 2460
tagaaaacat gcattttgaa gttcaacatg taaagaatac ctcaagaaat aaagaagcaa
2520 ttttgtatac ctacaaactt tctaagggac tcacagaaga gaaaaattat
ggattaaaag 2580 ctgcagaggt gtcatcactt ccaccatcaa ttgtcttgga
tgccaaggaa atcacaactc 2640 aaattacgag acaaattttg caaaaccaaa
ggagtacccc tgagatggaa agacagagag 2700 ctgtgtacca tctagccact
aggcttgttc aaactgctcg aaactctcaa ttggatccag 2760 acagtttacg
aatatattta agtaacctca agaagaagta caaagaagat tttcccagga 2820
ccgaacaagt tccagaaaag actgaagaat aatcacaatt ctaatgtaat aatatatctt
2880 aattcaagga acctagaatt tatttttctc cttagagata aggaaaataa
catttgccaa 2940 atttcatatt ttaattgaaa attacattat attaacatca
caattgtcat ctatatattc 3000 tatatgaaaa atatttatta taacttaaca
aatgagaact acttaaagga atggttttta 3060 tgttaggaga aaatacaata
caccacaaaa aaaaa 3095 <210> SEQ ID NO 20 <211> LENGTH:
936 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 20 Met Leu Arg Pro Glu Ile Ser Ser Thr Ser
Pro Ser Ala Pro Ala Val 1 5 10 15 Ser Pro Val Val Gly Glu Thr Arg
Ser Pro Gln Gly Pro Arg Tyr Asn 20 25 30 Phe Gly Leu Gln Glu Thr
Pro Gln Ser Arg Pro Ser Val Gln Val Val 35 40 45 Ser Ala Ser Thr
Cys Pro Gly Thr Ser Gly Ala Ala Gly Asp Arg Ser 50 55 60 Ser Ser
Ser Ser Ser Leu Pro Cys Pro Ala Pro Asn Ser Arg Pro Ala 65 70 75 80
Gln Gly Ser Tyr Phe Gly Asn Lys Arg Ala Tyr Ala Glu Asn Thr Val 85
90 95 Ala Ser Asn Phe Thr Phe Gly Ala Ser Ser Ser Ser Ala Arg Asp
Thr 100 105 110 Asn Tyr Pro Gln Thr Leu Lys Thr Pro Leu Ser Thr Gly
Asn Pro Gln 115 120 125 Arg Ser Gly Tyr Lys Ser Trp Thr Pro Gln Val
Gly Tyr Ser Ala Ser 130 135 140 Ser Ser Ser Ala Ile Ser Ala His Ser
Pro Ser Val Ile Val Ala Val 145 150 155 160 Val Glu Gly Arg Gly Leu
Ala Arg Gly Glu Ile Gly Met Ala Ser Ile 165 170 175 Asp Leu Lys Asn
Pro Gln Ile Ile Leu Ser Gln Phe Ala Asp Asn Thr 180 185 190 Thr Tyr
Ala Lys Val Ile Thr Lys Leu Lys Ile Leu Ser Pro Leu Glu 195 200 205
Ile Ile Met Ser Asn Thr Ala Cys Ala Val Gly Asn Ser Thr Lys Leu 210
215 220 Phe Thr Leu Ile Thr Glu Asn Phe Lys Asn Val Asn Phe Thr Thr
Ile 225 230 235 240 Gln Arg Lys Tyr Phe Asn Glu Thr Lys Gly Leu Glu
Tyr Ile Glu Gln 245 250 255 Leu Cys Ile Ala Glu Phe Ser Thr Val Leu
Met Glu Val Gln Ser Lys 260 265 270 Tyr Tyr Cys Leu Ala Ala Val Ala
Ala Leu Leu Lys Tyr Val Glu Phe 275 280 285 Ile Gln Asn Ser Val Tyr
Ala Pro Lys Ser Leu Lys Ile Cys Phe Gln 290 295 300 Gly Ser Glu Gln
Thr Ala Met Ile Asp Ser Ser Ser Ala Gln Asn Leu 305 310 315 320 Glu
Leu Leu Ile Asn Asn Gln Asp Tyr Arg Asn Asn His Thr Leu Phe 325 330
335 Gly Val Leu Asn Tyr Thr Lys Thr Pro Gly Gly Ser Arg Arg Leu Arg
340 345 350 Ser Asn Ile Leu Glu Pro Leu Val Asp Ile Glu Thr Ile Asn
Met Arg 355 360 365 Leu Asp Cys Val Gln Glu Leu Leu Gln Asp Glu Glu
Leu Phe Phe Gly 370 375 380 Leu Gln Ser Val Ile Ser Arg Phe Leu Asp
Thr Glu Gln Leu Leu Ser 385 390 395 400 Val Leu Val Gln Ile Pro Glu
Gln Asp Thr Val Asn Ala Ala Glu Ser 405 410 415 Lys Ile Thr Asn Leu
Ile Tyr Leu Lys His Thr Leu Glu Leu Val Asp 420 425 430 Pro Leu Lys
Ile Ala Met Lys Asn Cys Asn Thr Pro Leu Leu Arg Ala 435 440 445 Tyr
Tyr Gly Ser Leu Glu Asp Lys Arg Phe Gly Ile Ile Leu Glu Lys 450 455
460 Ile Lys Thr Val Ile Asn Asp Asp Ala Arg Tyr Met Lys Gly Cys Leu
465 470 475 480 Asn Met Arg Thr Gln Lys Cys Tyr Ala Val Arg Ser Asn
Ile Asn Glu 485 490 495 Phe Leu Asp Ile Ala Arg Arg Thr Tyr Thr Glu
Ile Val Asp Asp Ile 500 505 510 Ala Gly Met Ile Ser Gln Leu Gly Glu
Lys Tyr Ser Leu Pro Leu Arg 515 520 525 Thr Ser Leu Ser Ser Val Arg
Gly Phe Phe Ile Gln Met Thr Thr Asp 530 535 540 Cys Ile Ala Leu Pro
Ser Asp Gln Leu Pro Ser Glu Phe Ile Lys Ile 545 550 555 560 Ser Lys
Val Lys Asn Ser Tyr Ser Phe Thr Ser Ala Asp Leu Ile Lys 565 570 575
Met Asn Glu Arg Cys Gln Glu Ser Leu Arg Glu Ile Tyr His Met Thr 580
585 590 Tyr Met Ile Val Cys Lys Leu Leu Ser Glu Ile Tyr Glu His Ile
His 595 600 605 Cys Leu Tyr Lys Leu Ser Asp Thr Val Ser Met Leu Asp
Met Leu Leu 610 615 620 Ser Phe Ala His Ala Cys Thr Leu Ser Asp Tyr
Val Arg Pro Glu Phe 625 630 635 640 Thr Asp Thr Leu Ala Ile Lys Gln
Gly Trp His Pro Ile Leu Glu Lys 645 650 655 Ile Ser Ala Glu Lys Pro
Ile Ala Asn Asn Thr Tyr Val Thr Glu Gly 660 665 670 Ser Asn Phe Leu
Ile Ile Thr Gly Pro Asn Met Ser Gly Lys Ser Thr 675 680 685 Tyr Leu
Lys Gln Ile Ala Leu Cys Gln Ile Met Ala Gln Ile Gly Ser 690 695 700
Tyr Val Pro Ala Glu Tyr Ser Ser Phe Arg Ile Ala Lys Gln Ile Phe 705
710 715 720 Thr Arg Ile Ser Thr Asp Asp Asp Ile Glu Thr Asn Ser Ser
Thr Phe 725 730 735 Met Lys Glu Met Lys Glu Ile Ala Tyr Ile Leu His
Asn Ala Asn Asp 740 745 750 Lys Ser Leu Ile Leu Ile Asp Glu Leu Gly
Arg Gly Thr Asn Thr Glu 755 760 765 Glu Gly Ile Gly Ile Cys Tyr Ala
Val Cys Glu Tyr Leu Leu Ser Leu 770 775 780 Lys Ala Phe Thr Leu Phe
Ala Thr His Phe Leu Glu Leu Cys His Ile 785 790 795 800
Asp Ala Leu Tyr Pro Asn Val Glu Asn Met His Phe Glu Val Gln His 805
810 815 Val Lys Asn Thr Ser Arg Asn Lys Glu Ala Ile Leu Tyr Thr Tyr
Lys 820 825 830 Leu Ser Lys Gly Leu Thr Glu Glu Lys Asn Tyr Gly Leu
Lys Ala Ala 835 840 845 Glu Val Ser Ser Leu Pro Pro Ser Ile Val Leu
Asp Ala Lys Glu Ile 850 855 860 Thr Thr Gln Ile Thr Arg Gln Ile Leu
Gln Asn Gln Arg Ser Thr Pro 865 870 875 880 Glu Met Glu Arg Gln Arg
Ala Val Tyr His Leu Ala Thr Arg Leu Val 885 890 895 Gln Thr Ala Arg
Asn Ser Gln Leu Asp Pro Asp Ser Leu Arg Ile Tyr 900 905 910 Leu Ser
Asn Leu Lys Lys Lys Tyr Lys Glu Asp Phe Pro Arg Thr Glu 915 920 925
Gln Val Pro Glu Lys Thr Glu Glu 930 935 <210> SEQ ID NO 21
<211> LENGTH: 2726 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 21 gcggtcggtc
agcggggcgt tctcccacct gtagcgactc agagcctcca agctcatggc 60
ctccttagga gcgaacccaa ggaggacacc gcagggaccg agacctgggg cggcctcctc
120 cggcttcccc agcccggccc cagtgccggg ccccagggag gccgaggagg
aggaagtcga 180 ggaggaggag gagctggccg agatccatct gtgtgtgctg
tggaattcag gatacttggg 240 cattgcctac tatgatacta gtgactccac
tatccacttc atgccagatg ccccagacca 300 cgagagcctc aagcttctcc
agagagttct ggatgagatc aatccccagt ctgttgttac 360 gagtgccaaa
caggatgaga atatgactcg atttctggga aagcttgcct cccaggagca 420
cagagagcct aaaagacctg aaatcatatt tttgccaagt gtggattttg gtctggagat
480 aagcaaacaa cgcctccttt ctggaaacta ctccttcatc ccagacgcca
tgactgccac 540 tgagaaaatc ctcttcctct cttccattat tccctttgac
tgcctcctca cagttcgagc 600 acttggaggg ctgctgaagt tcctgggtcg
aagaagaatc ggggttgaac tggaagacta 660 taatgtcagc gtccccatcc
tgggctttaa gaaatttatg ttgactcatc tggtgaacat 720 agatcaagac
acttacagtg ttctacagat ttttaagagt gagtctcacc cctcagtgta 780
caaagtggcc agtggactga aggaggggct cagcctcttt ggaatcctca acagatgcca
840 ctgtaagtgg ggagagaagc tgctcaggct atggttcaca cgtccgactc
atgacctggg 900 ggagctcagt tctcgtctgg acgtcattca gttttttctg
ctgccccaga atctggacat 960 ggctcagatg ctgcatcggc tcctgggtca
catcaagaac gtgcctctga ttctgaaacg 1020 catgaagttg tcccacacca
aggtcagcga ctggcaggtt ctctacaaga ctgtgtacag 1080 tgccctgggc
ctgagggatg cctgccgctc cctgccgcag tccatccagc tctttcggga 1140
cattgcccaa gagttctctg atgacctgca ccatatcgcc agcctcattg ggaaagtagt
1200 ggactttgag ggcagccttg ctgaaaatcg cttcacagtc ctccccaaca
tagatcctga 1260 aattgatgag aaaaagcgaa gactgatggg acttcccagt
ttccttactg aggttgcccg 1320 caaggagctg gagaatctgg actcccgtat
tccttcatgc agtgtcatct acatccctct 1380 gattggcttc cttctttcta
ttccccgcct gccttccatg gtagaggcca gtgactttga 1440 gattaatgga
ctggacttca tgtttctctc agaggagaag ctgcactatc gtagtgcccg 1500
aaccaaggag ctggatgcat tgctggggga cctgcactgc gagatccggg accaggagac
1560 gctgctgatg taccagctac agtgccaggt gctggcacga gcagctgtct
taacccgagt 1620 attggacctt gcctcccgcc tggacgtcct gctggctctt
gccagtgctg cccgggacta 1680 tggctactca aggccgcgtt actccccaca
agtccttggg gtacgaatcc agaatggcag 1740 acatcctctg atggaactct
gtgcccgaac ctttgtgccc aactccacag aatgtggtgg 1800 ggacaaaggg
agggtcaaag tcatcactgg acccaactca tcagggaaga gcatatacct 1860
caaacaggta ggcttgatca cattcatggc cctggtaggc agctttgtgc cagcagagga
1920 ggccgaaatt ggggcagtag acgccatctt cacacgaatt catagctgcg
aatccatctc 1980 ccttggcctc tccaccttca tgatcgacct caaccagcag
gtggcgaaag cagtgaacaa 2040 tgccactgca cagtcgctgg tccttattga
tgaatttgga aagggaacca acacggtgga 2100 tgggctcgcg cttctggccg
ctgtgctccg acactggctg gcacgtggac ccacatgccc 2160 ccacatcttt
gtggccacca actttctgag ccttgttcag ctacaactgc tgccacaagg 2220
gcccctggtg cagtatttga ccatggagac ctgtgaggat ggcaacgatc ttgtcttctt
2280 ctatcaggtt tgcgaaggtg ttgcgaaggc cagccatgcc tcccacacag
ctgcccaggc 2340 tgggcttcct gacaagcttg tggctcgtgg caaggaggtc
tcagacttga tccgcagtgg 2400 aaaacccatc aagcctgtca aggatttgct
aaagaagaac caaatggaaa attgccagac 2460 attagtggat aagtttatga
aactggattt ggaagatcct aacctggact tgaacgtttt 2520 catgagccag
gaagtgctgc ctgctgccac cagcatcctc tgagagtcct tccagtgtcc 2580
tccccagcct cctgagactc cggtgggctg ccatgccctc tttgtttcct tatctccctc
2640 agacgcagag tttttagttt ctctagaaat tttgtttcat attaggaata
aagtttattt 2700 tgaagaaaaa aaaaaaaaaa aaaaaa 2726 <210> SEQ
ID NO 22 <211> LENGTH: 835 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 22 Met Ala Ser Leu Gly
Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg 1 5 10 15 Pro Gly Ala
Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly 20 25 30 Pro
Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala 35 40
45 Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala
50 55 60 Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp
Ala Pro 65 70 75 80 Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu
Asp Glu Ile Asn 85 90 95 Pro Gln Ser Val Val Thr Ser Ala Lys Gln
Asp Glu Asn Met Thr Arg 100 105 110 Phe Leu Gly Lys Leu Ala Ser Gln
Glu His Arg Glu Pro Lys Arg Pro 115 120 125 Glu Ile Ile Phe Leu Pro
Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 130 135 140 Gln Arg Leu Leu
Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr 145 150 155 160 Ala
Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys 165 170
175 Leu Leu Thr Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly Arg
180 185 190 Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val
Pro Ile 195 200 205 Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val
Asn Ile Asp Gln 210 215 220 Asp Thr Tyr Ser Val Leu Gln Ile Phe Lys
Ser Glu Ser His Pro Ser 225 230 235 240 Val Tyr Lys Val Ala Ser Gly
Leu Lys Glu Gly Leu Ser Leu Phe Gly 245 250 255 Ile Leu Asn Arg Cys
His Cys Lys Trp Gly Glu Lys Leu Leu Arg Leu 260 265 270 Trp Phe Thr
Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg Leu 275 280 285 Asp
Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala Gln 290 295
300 Met Leu His Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile Leu
305 310 315 320 Lys Arg Met Lys Leu Ser His Thr Lys Val Ser Asp Trp
Gln Val Leu 325 330 335 Tyr Lys Thr Val Tyr Ser Ala Leu Gly Leu Arg
Asp Ala Cys Arg Ser 340 345 350 Leu Pro Gln Ser Ile Gln Leu Phe Arg
Asp Ile Ala Gln Glu Phe Ser 355 360 365 Asp Asp Leu His His Ile Ala
Ser Leu Ile Gly Lys Val Val Asp Phe 370 375 380 Glu Gly Ser Leu Ala
Glu Asn Arg Phe Thr Val Leu Pro Asn Ile Asp 385 390 395 400 Pro Glu
Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro Ser Phe 405 410 415
Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser Arg Ile 420
425 430 Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu Leu
Ser 435 440 445 Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe
Glu Ile Asn 450 455 460 Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys
Leu His Tyr Arg Ser 465 470 475 480 Ala Arg Thr Lys Glu Leu Asp Ala
Leu Leu Gly Asp Leu His Cys Glu 485 490 495 Ile Arg Asp Gln Glu Thr
Leu Leu Met Tyr Gln Leu Gln Cys Gln Val 500 505 510 Leu Ala Arg Ala
Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser Arg 515 520 525 Leu Asp
Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp Tyr Gly Tyr 530 535 540
Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile Gln Asn 545
550 555 560 Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val
Pro Asn 565 570 575 Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys
Val Ile Thr Gly 580 585 590 Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu
Lys Gln Val Gly Leu Ile 595 600 605 Thr Phe Met Ala Leu Val Gly Ser
Phe Val Pro Ala Glu Glu Ala Glu
610 615 620 Ile Gly Ala Val Asp Ala Ile Phe Thr Arg Ile His Ser Cys
Glu Ser 625 630 635 640 Ile Ser Leu Gly Leu Ser Thr Phe Met Ile Asp
Leu Asn Gln Gln Val 645 650 655 Ala Lys Ala Val Asn Asn Ala Thr Ala
Gln Ser Leu Val Leu Ile Asp 660 665 670 Glu Phe Gly Lys Gly Thr Asn
Thr Val Asp Gly Leu Ala Leu Leu Ala 675 680 685 Ala Val Leu Arg His
Trp Leu Ala Arg Gly Pro Thr Cys Pro His Ile 690 695 700 Phe Val Ala
Thr Asn Phe Leu Ser Leu Val Gln Leu Gln Leu Leu Pro 705 710 715 720
Gln Gly Pro Leu Val Gln Tyr Leu Thr Met Glu Thr Cys Glu Asp Gly 725
730 735 Asn Asp Leu Val Phe Phe Tyr Gln Val Cys Glu Gly Val Ala Lys
Ala 740 745 750 Ser His Ala Ser His Thr Ala Ala Gln Ala Gly Leu Pro
Asp Lys Leu 755 760 765 Val Ala Arg Gly Lys Glu Val Ser Asp Leu Ile
Arg Ser Gly Lys Pro 770 775 780 Ile Lys Pro Val Lys Asp Leu Leu Lys
Lys Asn Gln Met Glu Asn Cys 785 790 795 800 Gln Thr Leu Val Asp Lys
Phe Met Lys Leu Asp Leu Glu Asp Pro Asn 805 810 815 Leu Asp Leu Asn
Val Phe Met Ser Gln Glu Val Leu Pro Ala Ala Thr 820 825 830 Ser Ile
Leu 835 <210> SEQ ID NO 23 <211> LENGTH: 4264
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 23 atttcccgcc agcaggagcc gcgcggtaga
tgcggtgctt ttaggagctc cgtccgacag 60 aacggttggg ccttgccggc
tgtcggtatg tcgcgacaga gcaccctgta cagcttcttc 120 cccaagtctc
cggcgctgag tgatgccaac aaggcctcgg ccagggcctc acgcgaaggc 180
ggccgtgccg ccgctgcccc cggggcctct ccttccccag gcggggatgc ggcctggagc
240 gaggctgggc ctgggcccag gcccttggcg cgatccgcgt caccgcccaa
ggcgaagaac 300 ctcaacggag ggctgcggag atcggtagcg cctgctgccc
ccaccagttg tgacttctca 360 ccaggagatt tggtttgggc caagatggag
ggttacccct ggtggccttg tctggtttac 420 aaccacccct ttgatggaac
attcatccgc gagaaaggga aatcagtccg tgttcatgta 480 cagttttttg
atgacagccc aacaaggggc tgggttagca aaaggctttt aaagccatat 540
acaggttcaa aatcaaagga agcccagaag ggaggtcatt tttacagtgc aaagcctgaa
600 atactgagag caatgcaacg tgcagatgaa gccttaaata aagacaagat
taagaggctt 660 gaattggcag tttgtgatga gccctcagag ccagaagagg
aagaagagat ggaggtaggc 720 acaacttacg taacagataa gagtgaagaa
gataatgaaa ttgagagtga agaggaagta 780 cagcctaaga cacaaggatc
taggcgaagt agccgccaaa taaaaaaacg aagggtcata 840 tcagattctg
agagtgacat tggtggctct gatgtggaat ttaagccaga cactaaggag 900
gaaggaagca gtgatgaaat aagcagtgga gtgggggata gtgagagtga aggcctgaac
960 agccctgtca aagttgctcg aaagcggaag agaatggtga ctggaaatgg
ctctcttaaa 1020 aggaaaagct ctaggaagga aacgccctca gccaccaaac
aagcaactag catttcatca 1080 gaaaccaaga atactttgag agctttctct
gcccctcaaa attctgaatc ccaagcccac 1140 gttagtggag gtggtgatga
cagtagtcgc cctactgttt ggtatcatga aactttagaa 1200 tggcttaagg
aggaaaagag aagagatgag cacaggagga ggcctgatca ccccgatttt 1260
gatgcatcta cactctatgt gcctgaggat ttcctcaatt cttgtactcc tgggatgagg
1320 aagtggtggc agattaagtc tcagaacttt gatcttgtca tctgttacaa
ggtggggaaa 1380 ttttatgagc tgtaccacat ggatgctctt attggagtca
gtgaactggg gctggtattc 1440 atgaaaggca actgggccca ttctggcttt
cctgaaattg catttggccg ttattcagat 1500 tccctggtgc agaagggcta
taaagtagca cgagtggaac agactgagac tccagaaatg 1560 atggaggcac
gatgtagaaa gatggcacat atatccaagt atgatagagt ggtgaggagg 1620
gagatctgta ggatcattac caagggtaca cagacttaca gtgtgctgga aggtgatccc
1680 tctgagaact acagtaagta tcttcttagc ctcaaagaaa aagaggaaga
ttcttctggc 1740 catactcgtg catatggtgt gtgctttgtt gatacttcac
tgggaaagtt tttcataggt 1800 cagttttcag atgatcgcca ttgttcgaga
tttaggactc tagtggcaca ctatccccca 1860 gtacaagttt tatttgaaaa
aggaaatctc tcaaaggaaa ctaaaacaat tctaaagagt 1920 tcattgtcct
gttctcttca ggaaggtctg atacccggct cccagttttg ggatgcatcc 1980
aaaactttga gaactctcct tgaggaagaa tattttaggg aaaagctaag tgatggcatt
2040 ggggtgatgt taccccaggt gcttaaaggt atgacttcag agtctgattc
cattgggttg 2100 acaccaggag agaaaagtga attggccctc tctgctctag
gtggttgtgt cttctacctc 2160 aaaaaatgcc ttattgatca ggagctttta
tcaatggcta attttgaaga atatattccc 2220 ttggattctg acacagtcag
cactacaaga tctggtgcta tcttcaccaa agcctatcaa 2280 cgaatggtgc
tagatgcagt gacattaaac aacttggaga tttttctgaa tggaacaaat 2340
ggttctactg aaggaaccct actagagagg gttgatactt gccatactcc ttttggtaag
2400 cggctcctaa agcaatggct ttgtgcccca ctctgtaacc attatgctat
taatgatcgt 2460 ctagatgcca tagaagacct catggttgtg cctgacaaaa
tctccgaagt tgtagagctt 2520 ctaaagaagc ttccagatct tgagaggcta
ctcagtaaaa ttcataatgt tgggtctccc 2580 ctgaagagtc agaaccaccc
agacagcagg gctataatgt atgaagaaac tacatacagc 2640 aagaagaaga
ttattgattt tctttctgct ctggaaggat tcaaagtaat gtgtaaaatt 2700
atagggatca tggaagaagt tgctgatggt tttaagtcta aaatccttaa gcaggtcatc
2760 tctctgcaga caaaaaatcc tgaaggtcgt tttcctgatt tgactgtaga
attgaaccga 2820 tgggatacag cctttgacca tgaaaaggct cgaaagactg
gacttattac tcccaaagca 2880 ggctttgact ctgattatga ccaagctctt
gctgacataa gagaaaatga acagagcctc 2940 ctggaatacc tagagaaaca
gcgcaacaga attggctgta ggaccatagt ctattggggg 3000 attggtagga
accgttacca gctggaaatt cctgagaatt tcaccactcg caatttgcca 3060
gaagaatacg agttgaaatc taccaagaag ggctgtaaac gatactggac caaaactatt
3120 gaaaagaagt tggctaatct cataaatgct gaagaacgga gggatgtatc
attgaaggac 3180 tgcatgcggc gactgttcta taactttgat aaaaattaca
aggactggca gtctgctgta 3240 gagtgtatcg cagtgttgga tgttttactg
tgcctggcta actatagtcg agggggtgat 3300 ggtcctatgt gtcgcccagt
aattctgttg ccggaagata cccccccctt cttagagctt 3360 aaaggatcac
gccatccttg cattacgaag actttttttg gagatgattt tattcctaat 3420
gacattctaa taggctgtga ggaagaggag caggaaaatg gcaaagccta ttgtgtgctt
3480 gttactggac caaatatggg gggcaagtct acgcttatga gacaggctgg
cttattagct 3540 gtaatggccc agatgggttg ttacgtccct gctgaagtgt
gcaggctcac accaattgat 3600 agagtgttta ctagacttgg tgcctcagac
agaataatgt caggtgaaag tacatttttt 3660 gttgaattaa gtgaaactgc
cagcatactc atgcatgcaa cagcacattc tctggtgctt 3720 gtggatgaat
taggaagagg tactgcaaca tttgatggga cggcaatagc aaatgcagtt 3780
gttaaagaac ttgctgagac tataaaatgt cgtacattat tttcaactca ctaccattca
3840 ttagtagaag attattctca aaatgttgct gtgcgcctag gacatatggc
atgcatggta 3900 gaaaatgaat gtgaagaccc cagccaggag actattacgt
tcctctataa attcattaag 3960 ggagcttgtc ctaaaagcta tggctttaat
gcagcaaggc ttgctaatct cccagaggaa 4020 gttattcaaa agggacatag
aaaagcaaga gaatttgaga agatgaatca gtcactacga 4080 ttatttcggg
aagtttgcct ggctagtgaa aggtcaactg tagatgctga agctgtccat 4140
aaattgctga ctttgattaa ggaattatag actgactaca ttggaagctt tgagttgact
4200 tctgaccaaa ggtggtaaat tcagacaaca ttatgatcta ataaacttta
ttttttaaaa 4260 atga 4264 <210> SEQ ID NO 24 <211>
LENGTH: 1360 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 24 Met Ser Arg Gln Ser Thr Leu Tyr
Ser Phe Phe Pro Lys Ser Pro Ala 1 5 10 15 Leu Ser Asp Ala Asn Lys
Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly 20 25 30 Arg Ala Ala Ala
Ala Pro Gly Ala Ser Pro Ser Pro Gly Gly Asp Ala 35 40 45 Ala Trp
Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu Ala Arg Ser Ala 50 55 60
Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly Gly Leu Arg Arg Ser Val 65
70 75 80 Ala Pro Ala Ala Pro Thr Ser Cys Asp Phe Ser Pro Gly Asp
Leu Val 85 90 95 Trp Ala Lys Met Glu Gly Tyr Pro Trp Trp Pro Cys
Leu Val Tyr Asn 100 105 110 His Pro Phe Asp Gly Thr Phe Ile Arg Glu
Lys Gly Lys Ser Val Arg 115 120 125 Val His Val Gln Phe Phe Asp Asp
Ser Pro Thr Arg Gly Trp Val Ser 130 135 140 Lys Arg Leu Leu Lys Pro
Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln 145 150 155 160 Lys Gly Gly
His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg Ala Met 165 170 175 Gln
Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile Lys Arg Leu Glu 180 185
190 Leu Ala Val Cys Asp Glu Pro Ser Glu Pro Glu Glu Glu Glu Glu Met
195 200 205 Glu Val Gly Thr Thr Tyr Val Thr Asp Lys Ser Glu Glu Asp
Asn Glu 210 215 220 Ile Glu Ser Glu Glu Glu Val Gln Pro Lys Thr Gln
Gly Ser Arg Arg 225 230 235 240 Ser Ser Arg Gln Ile Lys Lys Arg Arg
Val Ile Ser Asp Ser Glu Ser 245 250 255 Asp Ile Gly Gly Ser Asp Val
Glu Phe Lys Pro Asp Thr Lys Glu Glu
260 265 270 Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu
Ser Glu 275 280 285 Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg
Lys Arg Met Val 290 295 300 Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser
Ser Arg Lys Glu Thr Pro 305 310 315 320 Ser Ala Thr Lys Gln Ala Thr
Ser Ile Ser Ser Glu Thr Lys Asn Thr 325 330 335 Leu Arg Ala Phe Ser
Ala Pro Gln Asn Ser Glu Ser Gln Ala His Val 340 345 350 Ser Gly Gly
Gly Asp Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu 355 360 365 Thr
Leu Glu Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg 370 375
380 Arg Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu
385 390 395 400 Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp
Trp Gln Ile 405 410 415 Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr
Lys Val Gly Lys Phe 420 425 430 Tyr Glu Leu Tyr His Met Asp Ala Leu
Ile Gly Val Ser Glu Leu Gly 435 440 445 Leu Val Phe Met Lys Gly Asn
Trp Ala His Ser Gly Phe Pro Glu Ile 450 455 460 Ala Phe Gly Arg Tyr
Ser Asp Ser Leu Val Gln Lys Gly Tyr Lys Val 465 470 475 480 Ala Arg
Val Glu Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys 485 490 495
Arg Lys Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu 500
505 510 Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu
Glu 515 520 525 Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser
Leu Lys Glu 530 535 540 Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala
Tyr Gly Val Cys Phe 545 550 555 560 Val Asp Thr Ser Leu Gly Lys Phe
Phe Ile Gly Gln Phe Ser Asp Asp 565 570 575 Arg His Cys Ser Arg Phe
Arg Thr Leu Val Ala His Tyr Pro Pro Val 580 585 590 Gln Val Leu Phe
Glu Lys Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile 595 600 605 Leu Lys
Ser Ser Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly 610 615 620
Ser Gln Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu 625
630 635 640 Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met
Leu Pro 645 650 655 Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser
Ile Gly Leu Thr 660 665 670 Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser
Ala Leu Gly Gly Cys Val 675 680 685 Phe Tyr Leu Lys Lys Cys Leu Ile
Asp Gln Glu Leu Leu Ser Met Ala 690 695 700 Asn Phe Glu Glu Tyr Ile
Pro Leu Asp Ser Asp Thr Val Ser Thr Thr 705 710 715 720 Arg Ser Gly
Ala Ile Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp 725 730 735 Ala
Val Thr Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly 740 745
750 Ser Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro
755 760 765 Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu
Cys Asn 770 775 780 His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu
Asp Leu Met Val 785 790 795 800 Val Pro Asp Lys Ile Ser Glu Val Val
Glu Leu Leu Lys Lys Leu Pro 805 810 815 Asp Leu Glu Arg Leu Leu Ser
Lys Ile His Asn Val Gly Ser Pro Leu 820 825 830 Lys Ser Gln Asn His
Pro Asp Ser Arg Ala Ile Met Tyr Glu Glu Thr 835 840 845 Thr Tyr Ser
Lys Lys Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly 850 855 860 Phe
Lys Val Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp 865 870
875 880 Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr
Lys 885 890 895 Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu
Asn Arg Trp 900 905 910 Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys
Thr Gly Leu Ile Thr 915 920 925 Pro Lys Ala Gly Phe Asp Ser Asp Tyr
Asp Gln Ala Leu Ala Asp Ile 930 935 940 Arg Glu Asn Glu Gln Ser Leu
Leu Glu Tyr Leu Glu Lys Gln Arg Asn 945 950 955 960 Arg Ile Gly Cys
Arg Thr Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg 965 970 975 Tyr Gln
Leu Glu Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu 980 985 990
Glu Tyr Glu Leu Lys Ser Thr Lys Lys Gly Cys Lys Arg Tyr Trp Thr 995
1000 1005 Lys Thr Ile Glu Lys Lys Leu Ala Asn Leu Ile Asn Ala Glu
Glu 1010 1015 1020 Arg Arg Asp Val Ser Leu Lys Asp Cys Met Arg Arg
Leu Phe Tyr 1025 1030 1035 Asn Phe Asp Lys Asn Tyr Lys Asp Trp Gln
Ser Ala Val Glu Cys 1040 1045 1050 Ile Ala Val Leu Asp Val Leu Leu
Cys Leu Ala Asn Tyr Ser Arg 1055 1060 1065 Gly Gly Asp Gly Pro Met
Cys Arg Pro Val Ile Leu Leu Pro Glu 1070 1075 1080 Asp Thr Pro Pro
Phe Leu Glu Leu Lys Gly Ser Arg His Pro Cys 1085 1090 1095 Ile Thr
Lys Thr Phe Phe Gly Asp Asp Phe Ile Pro Asn Asp Ile 1100 1105 1110
Leu Ile Gly Cys Glu Glu Glu Glu Gln Glu Asn Gly Lys Ala Tyr 1115
1120 1125 Cys Val Leu Val Thr Gly Pro Asn Met Gly Gly Lys Ser Thr
Leu 1130 1135 1140 Met Arg Gln Ala Gly Leu Leu Ala Val Met Ala Gln
Met Gly Cys 1145 1150 1155 Tyr Val Pro Ala Glu Val Cys Arg Leu Thr
Pro Ile Asp Arg Val 1160 1165 1170 Phe Thr Arg Leu Gly Ala Ser Asp
Arg Ile Met Ser Gly Glu Ser 1175 1180 1185 Thr Phe Phe Val Glu Leu
Ser Glu Thr Ala Ser Ile Leu Met His 1190 1195 1200 Ala Thr Ala His
Ser Leu Val Leu Val Asp Glu Leu Gly Arg Gly 1205 1210 1215 Thr Ala
Thr Phe Asp Gly Thr Ala Ile Ala Asn Ala Val Val Lys 1220 1225 1230
Glu Leu Ala Glu Thr Ile Lys Cys Arg Thr Leu Phe Ser Thr His 1235
1240 1245 Tyr His Ser Leu Val Glu Asp Tyr Ser Gln Asn Val Ala Val
Arg 1250 1255 1260 Leu Gly His Met Ala Cys Met Val Glu Asn Glu Cys
Glu Asp Pro 1265 1270 1275 Ser Gln Glu Thr Ile Thr Phe Leu Tyr Lys
Phe Ile Lys Gly Ala 1280 1285 1290 Cys Pro Lys Ser Tyr Gly Phe Asn
Ala Ala Arg Leu Ala Asn Leu 1295 1300 1305 Pro Glu Glu Val Ile Gln
Lys Gly His Arg Lys Ala Arg Glu Phe 1310 1315 1320 Glu Lys Met Asn
Gln Ser Leu Arg Leu Phe Arg Glu Val Cys Leu 1325 1330 1335 Ala Ser
Glu Arg Ser Thr Val Asp Ala Glu Ala Val His Lys Leu 1340 1345 1350
Leu Thr Leu Ile Lys Glu Leu 1355 1360 <210> SEQ ID NO 25
<211> LENGTH: 1445 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 25 tttttttttt
tgatgttctc cagtgcctca gtggcagcag aactggccct gtatcaggcc 60
gctaccgcca ctccatgacc aacctccctg catacccccc cccccagcac ccctcccaca
120 ggaccgcttc tgtgtttggg acccaccagg cctttgcacc atacaacaaa
ccctcactct 180 ccggggcccg gtctgcgccc aggctgaaca ccacgaacgc
ctgggacgca gctcctcctt 240 ccctggggag ccagcccctc taccgctcca
gcctctccca cctgggaccg cagcacctgc 300 ccccaggatc ctccacctcc
ggtgcagtca gtgcctccct ccccagcggt ccctcaagca 360 gcccaggcga
gcgtccctgc cactgtgccc atgcagatgc caagccagca gagtcagcag 420
gcgctcgctg gagcgacccg aagccagagc agagcagagc aggtcataaa actacacgga
480 agagctgaaa gtgcccccag atgaggactg catcatctgc atggagaagc
tgtccgcagc 540 gtctggatac agcgatgtga ctgacagcaa ggcaatgggg
cccctggctg tgggctgcct 600 caccaagtgc agccacgcct tccacctgct
gtgcctcctg gccatgtact gcaacggcaa 660 taagggccct gagcacccca
atcccggaaa gccgttcact gccagagggt ttcccgccag 720 tgctaccttc
cagacaacgc cagggccgca agcctccagg ggcttccaga acccggagac 780
actggctgac attccggcct ccccacagct gctgaccgat ggccactaca tgacgctgcc
840 cgtgtctccg gaccagctgc cctgtgacga ccccatggcg ggcagcggag
gcgcccccgt 900 gctgcgggtg ggccatgacc acggctgcca ccagcagcca
cgtatctgca acgcgcccct 960
ccctggccct ggaccctatc gtacagaacc tgctaaggcc atcaaaccta ttgatcggaa
1020 gtcagtccat cagatttgct ctgggccagt ggtactgagt ctaagcactg
cagtgaagga 1080 gttagtagaa aacagtctgg atgctggtgc cactaatatt
gatctaaagc ttaaggacta 1140 tggaatggat ctcattgaag tttcaggcaa
tggatgtggg gtagaagaag aaaacttcga 1200 aggcttaatg atgtcaccat
ttctacctgc cacgtctcgg cgaaggttgg gactcgactg 1260 gtgtttgatc
acgatgggaa aatcatccag aagaccccct acccccaccc cagagggacc 1320
acagtcagcg tgaagcagtt attttctacg ctacctgtgc gccataagga atttcaaagg
1380 aatattaaga agaaacatgc tgcttcccct tcgccttctg ccgtgattgt
cagttttaac 1440 cggaa 1445 <210> SEQ ID NO 26 <211>
LENGTH: 270 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 26 Met Glu Lys Leu Ser Ala Ala Ser
Gly Tyr Ser Asp Val Thr Asp Ser 1 5 10 15 Lys Ala Met Gly Pro Leu
Ala Val Gly Cys Leu Thr Lys Cys Ser His 20 25 30 Ala Phe His Leu
Leu Cys Leu Leu Ala Met Tyr Cys Asn Gly Asn Lys 35 40 45 Gly Pro
Glu His Pro Asn Pro Gly Lys Pro Phe Thr Ala Arg Gly Phe 50 55 60
Pro Ala Ser Ala Thr Phe Gln Thr Thr Pro Gly Pro Gln Ala Ser Arg 65
70 75 80 Gly Phe Gln Asn Pro Glu Thr Leu Ala Asp Ile Pro Ala Ser
Pro Gln 85 90 95 Leu Leu Thr Asp Gly His Tyr Met Thr Leu Pro Val
Ser Pro Asp Gln 100 105 110 Leu Pro Cys Asp Asp Pro Met Ala Gly Ser
Gly Gly Ala Pro Val Leu 115 120 125 Arg Val Gly His Asp His Gly Cys
His Gln Gln Pro Arg Ile Cys Asn 130 135 140 Ala Pro Leu Pro Gly Pro
Gly Pro Tyr Arg Thr Glu Pro Ala Lys Ala 145 150 155 160 Ile Lys Pro
Ile Asp Arg Lys Ser Val His Gln Ile Cys Ser Gly Pro 165 170 175 Val
Val Leu Ser Leu Ser Thr Ala Val Lys Glu Leu Val Glu Asn Ser 180 185
190 Leu Asp Ala Gly Ala Thr Asn Ile Asp Leu Lys Leu Lys Asp Tyr Gly
195 200 205 Met Asp Leu Ile Glu Val Ser Gly Asn Gly Cys Gly Val Glu
Glu Glu 210 215 220 Asn Phe Glu Gly Leu Met Met Ser Pro Phe Leu Pro
Ala Thr Ser Arg 225 230 235 240 Arg Arg Leu Gly Leu Asp Trp Cys Leu
Ile Thr Met Gly Lys Ser Ser 245 250 255 Arg Arg Pro Pro Thr Pro Thr
Pro Glu Gly Pro Gln Ser Ala 260 265 270 <210> SEQ ID NO 27
<211> LENGTH: 795 <212> TYPE: DNA <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 27 atgtgtcctt ggcggcctag
actaggccgt cgctgtatgg tgagccccag ggaggcggat 60 ctgggccccc
agaaggacac ccgcctggat ttgccccgta gcccggcccg ggcccctcgg 120
gagcagaaca gccttggtga ggtggacagg aggggacctc gcgagcagac gcgcgcgcca
180 gcgacagcag ccccgccccg gcctctcggg agccgggggg cagaggctgc
ggagccccag 240 gagggtctat cagccacagt ctctgcatgt ttccaagagc
aacaggaaat gaacacattg 300 caggggccag tgtcattcaa agatgtggct
gtggatttca cccaggagga gtggcggcaa 360 ctggaccctg atgagaagat
agcatacggg gatgtgatgt tggagaacta cagccatcta 420 gtttctgtgg
ggtatgatta tcaccaagcc aaacatcatc atggagtgga ggtgaaggaa 480
gtggagcagg gagaggagcc gtggataatg gaaggtgaat ttccatgtca acatagtcca
540 gaacctgcta aggccatcaa acctattgat cggaagtcag tccatcagat
ttgctctggg 600 ccagtggtac tgagtctaag cactgcagtg aaggagttag
tagaaaacag tctggatgct 660 ggtgccacta atattgatct aaagcttaag
gactatggag tggatctcat tgaagtttca 720 gacaatggat gtggggtaga
agaagaaaac tttgaaggct taatctcttt cagctctgaa 780 acatcacaca tgtaa
795 <210> SEQ ID NO 28 <211> LENGTH: 260 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
28 Met Cys Pro Trp Arg Pro Arg Leu Gly Arg Arg Cys Met Val Ser Pro
1 5 10 15 Arg Glu Ala Asp Leu Gly Pro Gln Lys Asp Thr Arg Leu Asp
Leu Pro 20 25 30 Arg Ser Pro Ala Arg Ala Pro Arg Glu Gln Asn Ser
Leu Gly Glu Val 35 40 45 Asp Arg Arg Gly Pro Arg Glu Gln Thr Arg
Ala Pro Ala Thr Ala Ala 50 55 60 Pro Pro Arg Pro Leu Gly Ser Arg
Gly Ala Glu Ala Ala Glu Pro Gln 65 70 75 80 Glu Gly Leu Ser Ala Thr
Val Ser Ala Cys Phe Gln Glu Gln Gln Glu 85 90 95 Met Asn Thr Leu
Gln Gly Pro Val Ser Phe Lys Asp Val Ala Val Asp 100 105 110 Phe Thr
Gln Glu Glu Trp Arg Gln Leu Asp Pro Asp Glu Lys Ile Ala 115 120 125
Tyr Gly Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Val Gly 130
135 140 Tyr Asp Tyr His Gln Ala Lys His His His Gly Val Glu Val Lys
Glu 145 150 155 160 Val Glu Gln Gly Glu Glu Pro Trp Ile Met Glu Gly
Glu Phe Pro Cys 165 170 175 Gln His Ser Pro Glu Pro Ala Lys Ala Ile
Lys Pro Ile Asp Arg Lys 180 185 190 Ser Val His Gln Ile Cys Ser Gly
Pro Val Val Leu Ser Leu Ser Thr 195 200 205 Ala Val Lys Glu Leu Val
Glu Asn Ser Leu Asp Ala Gly Ala Thr Asn 210 215 220 Ile Asp Leu Lys
Leu Lys Asp Tyr Gly Val Asp Leu Ile Glu Val Ser 225 230 235 240 Asp
Asn Gly Cys Gly Val Glu Glu Glu Asn Phe Glu Gly Leu Ile Ser 245 250
255 Phe Ser Ser Glu 260 <210> SEQ ID NO 29 <211>
LENGTH: 3218 <212> TYPE: DNA <213> ORGANISM:
Saccharomyces cerevisiae <400> SEQUENCE: 29 aaataggaat
gtgatacctt ctattgcatg caaagatagt gtaggaggcg ctgctattgc 60
caaagacttt tgagaccgct tgctgtttca ttatagttga ggagttctcg aagacgagaa
120 attagcagtt ttcggtgttt agtaatcgcg ctagcatgct aggacaattt
aactgcaaaa 180 ttttgatacg atagtgatag taaatggaag gtaaaaataa
catagaccta tcaataagca 240 atgtctctca gaataaaagc acttgatgca
tcagtggtta acaaaattgc tgcaggtgag 300 atcataatat cccccgtaaa
tgctctcaaa gaaatgatgg agaattccat cgatgcgaat 360 gctacaatga
ttgatattct agtcaaggaa ggaggaatta aggtacttca aataacagat 420
aacggatctg gaattaataa agcagacctg ccaatcttat gtgagcgatt cacgacgtcc
480 aaattacaaa aattcgaaga tttgagtcag attcaaacgt atggattccg
aggagaagct 540 ttagccagta tctcacatgt ggcaagagtc acagtaacga
caaaagttaa agaagacaga 600 tgtgcatgga gagtttcata tgcagaaggt
aagatgttgg aaagccccaa acctgttgct 660 ggaaaagacg gtaccacgat
cctagttgaa gacctttttt tcaatattcc ttctagatta 720 agggccttga
ggtcccataa tgatgaatac tctaaaatat tagatgttgt cgggcgatac 780
gccattcatt ccaaggacat tggcttttct tgtaaaaagt tcggagactc taattattct
840 ttatcagtta aaccttcata tacagtccag gataggatta ggactgtgtt
caataaatct 900 gtggcttcga atttaattac ttttcatatc agcaaagtag
aagatttaaa cctggaaagc 960 gttgatggaa aggtgtgtaa tttgaatttc
atatccaaaa agtccatttc attaattttt 1020 ttcattaata atagactagt
gacatgtgat cttctaagaa gagctttgaa cagcgtttac 1080 tccaattatc
tgccaaaggg cttcagacct tttatttatt tgggaattgt tatagatccg 1140
gcggctgttg atgttaacgt tcacccgaca aagagagagg ttcgtttcct gagccaagat
1200 gagatcatag agaaaatcgc caatcaattg cacgccgaat tatctgccat
tgatacttca 1260 cgtactttca aggcttcttc aatttcaaca aacaagccag
agtcattgat accatttaat 1320 gacaccatag aaagtgatag gaataggaag
agtctccgac aagcccaagt ggtagagaat 1380 tcatatacga cagccaatag
tcaactaagg aaagcgaaaa gacaagagaa taaactagtc 1440 agaatagatg
cttcacaagc taaaattacg tcatttttat cctcaagtca acagttcaac 1500
tttgaaggat cgtctacaaa gcgacaactg agtgaaccca aggtaacaaa tgtaagccac
1560 tcccaagagg cagaaaagct gacactaaat gaaagcgaac aaccgcgtga
tgccaataca 1620 atcaatgata atgacttgaa ggatcaacct aagaagaaac
aaaagttggg ggattataaa 1680 gttccaagca ttgccgatga cgaaaagaat
gcactcccga tttcaaaaga cgggtatatt 1740 agagtaccta aggagcgagt
taatgttaat cttacgagta tcaagaaatt gcgtgaaaaa 1800 gtagatgatt
cgatacatcg agaactaaca gacatttttg caaatttgaa ttacgttggg 1860
gttgtagatg aggaaagaag attagccgct attcagcatg acttaaagct ttttttaata
1920 gattacggat ctgtgtgcta tgagctattc tatcagattg gtttgacaga
cttcgcaaac 1980 tttggtaaga taaacctaca gagtacaaat gtgtcagatg
atatagtttt gtataatctc 2040 ctatcagaat ttgacgagtt aaatgacgat
gcttccaaag aaaaaataat tagtaaaata 2100 tgggacatga gcagtatgct
aaatgagtac tattccatag aattggtgaa tgatggtcta 2160 gataatgact
taaagtctgt gaagctaaaa tctctaccac tacttttaaa aggctacatt 2220
ccatctctgg tcaagttacc attttttata tatcgcctgg gtaaagaagt tgattgggag
2280
gatgaacaag agtgtctaga tggtatttta agagagattg cattactcta tatacctgat
2340 atggttccga aagtcgatac actcgatgca tcgttgtcag aagacgaaaa
agcccagttt 2400 ataaatagaa aggaacacat atcctcatta ctagaacacg
ttctcttccc ttgtatcaaa 2460 cgaaggttcc tggcccctag acacattctc
aaggatgtcg tggaaatagc caaccttcca 2520 gatctataca aagtttttga
gaggtgttaa ctttaaaacg ttttggctgt aataccaaag 2580 tttttgttta
tttcctgagt gtgattgtgt ttcatttgaa agtgtatgcc ctttccttta 2640
acgattcatc cgcgagattt caaaggatat gaaatatggt tgcagttagg aaagtatgtc
2700 agaaatgtat attcggattg aaactcttct aatagttctg aagtcacttg
gttccgtatt 2760 gttttcgtcc tcttcctcaa gcaacgattc ttgtctaagc
ttattcaacg gtaccaaaga 2820 cccgagtcct tttatgagag aaaacatttc
atcatttttc aactcaatta tcttaatatc 2880 attttgtagt attttgaaaa
caggatggta aaacgaatca cctgaatcta gaagctgtac 2940 cttgtcccat
aaaagtttta atttactgag cctttcggtc aagtaaacta gtttatctag 3000
ttttgaaccg aatattgtgg gcagatttgc agtaagttca gttagatcta ctaaaagttg
3060 tttgacagca gccgattcca caaaaatttg gtaaaaggag atgaaagaga
cctcgcgcgt 3120 aatggtttgc atcaccatcg gatgtctgtt gaaaaactca
ctttttgcat ggaagttatt 3180 aacaataaga ctaatgatta ccttagaata
atgtataa 3218 <210> SEQ ID NO 30 <211> LENGTH: 769
<212> TYPE: PRT <213> ORGANISM: Saccharomyces
cerevisiae <400> SEQUENCE: 30 Met Ser Leu Arg Ile Lys Ala Leu
Asp Ala Ser Val Val Asn Lys Ile 1 5 10 15 Ala Ala Gly Glu Ile Ile
Ile Ser Pro Val Asn Ala Leu Lys Glu Met 20 25 30 Met Glu Asn Ser
Ile Asp Ala Asn Ala Thr Met Ile Asp Ile Leu Val 35 40 45 Lys Glu
Gly Gly Ile Lys Val Leu Gln Ile Thr Asp Asn Gly Ser Gly 50 55 60
Ile Asn Lys Ala Asp Leu Pro Ile Leu Cys Glu Arg Phe Thr Thr Ser 65
70 75 80 Lys Leu Gln Lys Phe Glu Asp Leu Ser Gln Ile Gln Thr Tyr
Gly Phe 85 90 95 Arg Gly Glu Ala Leu Ala Ser Ile Ser His Val Ala
Arg Val Thr Val 100 105 110 Thr Thr Lys Val Lys Glu Asp Arg Cys Ala
Trp Arg Val Ser Tyr Ala 115 120 125 Glu Gly Lys Met Leu Glu Ser Pro
Lys Pro Val Ala Gly Lys Asp Gly 130 135 140 Thr Thr Ile Leu Val Glu
Asp Leu Phe Phe Asn Ile Pro Ser Arg Leu 145 150 155 160 Arg Ala Leu
Arg Ser His Asn Asp Glu Tyr Ser Lys Ile Leu Asp Val 165 170 175 Val
Gly Arg Tyr Ala Ile His Ser Lys Asp Ile Gly Phe Ser Cys Lys 180 185
190 Lys Phe Gly Asp Ser Asn Tyr Ser Leu Ser Val Lys Pro Ser Tyr Thr
195 200 205 Val Gln Asp Arg Ile Arg Thr Val Phe Asn Lys Ser Val Ala
Ser Asn 210 215 220 Leu Ile Thr Phe His Ile Ser Lys Val Glu Asp Leu
Asn Leu Glu Ser 225 230 235 240 Val Asp Gly Lys Val Cys Asn Leu Asn
Phe Ile Ser Lys Lys Ser Ile 245 250 255 Ser Leu Ile Phe Phe Ile Asn
Asn Arg Leu Val Thr Cys Asp Leu Leu 260 265 270 Arg Arg Ala Leu Asn
Ser Val Tyr Ser Asn Tyr Leu Pro Lys Gly Phe 275 280 285 Arg Pro Phe
Ile Tyr Leu Gly Ile Val Ile Asp Pro Ala Ala Val Asp 290 295 300 Val
Asn Val His Pro Thr Lys Arg Glu Val Arg Phe Leu Ser Gln Asp 305 310
315 320 Glu Ile Ile Glu Lys Ile Ala Asn Gln Leu His Ala Glu Leu Ser
Ala 325 330 335 Ile Asp Thr Ser Arg Thr Phe Lys Ala Ser Ser Ile Ser
Thr Asn Lys 340 345 350 Pro Glu Ser Leu Ile Pro Phe Asn Asp Thr Ile
Glu Ser Asp Arg Asn 355 360 365 Arg Lys Ser Leu Arg Gln Ala Gln Val
Val Glu Asn Ser Tyr Thr Thr 370 375 380 Ala Asn Ser Gln Leu Arg Lys
Ala Lys Arg Gln Glu Asn Lys Leu Val 385 390 395 400 Arg Ile Asp Ala
Ser Gln Ala Lys Ile Thr Ser Phe Leu Ser Ser Ser 405 410 415 Gln Gln
Phe Asn Phe Glu Gly Ser Ser Thr Lys Arg Gln Leu Ser Glu 420 425 430
Pro Lys Val Thr Asn Val Ser His Ser Gln Glu Ala Glu Lys Leu Thr 435
440 445 Leu Asn Glu Ser Glu Gln Pro Arg Asp Ala Asn Thr Ile Asn Asp
Asn 450 455 460 Asp Leu Lys Asp Gln Pro Lys Lys Lys Gln Lys Leu Gly
Asp Tyr Lys 465 470 475 480 Val Pro Ser Ile Ala Asp Asp Glu Lys Asn
Ala Leu Pro Ile Ser Lys 485 490 495 Asp Gly Tyr Ile Arg Val Pro Lys
Glu Arg Val Asn Val Asn Leu Thr 500 505 510 Ser Ile Lys Lys Leu Arg
Glu Lys Val Asp Asp Ser Ile His Arg Glu 515 520 525 Leu Thr Asp Ile
Phe Ala Asn Leu Asn Tyr Val Gly Val Val Asp Glu 530 535 540 Glu Arg
Arg Leu Ala Ala Ile Gln His Asp Leu Lys Leu Phe Leu Ile 545 550 555
560 Asp Tyr Gly Ser Val Cys Tyr Glu Leu Phe Tyr Gln Ile Gly Leu Thr
565 570 575 Asp Phe Ala Asn Phe Gly Lys Ile Asn Leu Gln Ser Thr Asn
Val Ser 580 585 590 Asp Asp Ile Val Leu Tyr Asn Leu Leu Ser Glu Phe
Asp Glu Leu Asn 595 600 605 Asp Asp Ala Ser Lys Glu Lys Ile Ile Ser
Lys Ile Trp Asp Met Ser 610 615 620 Ser Met Leu Asn Glu Tyr Tyr Ser
Ile Glu Leu Val Asn Asp Gly Leu 625 630 635 640 Asp Asn Asp Leu Lys
Ser Val Lys Leu Lys Ser Leu Pro Leu Leu Leu 645 650 655 Lys Gly Tyr
Ile Pro Ser Leu Val Lys Leu Pro Phe Phe Ile Tyr Arg 660 665 670 Leu
Gly Lys Glu Val Asp Trp Glu Asp Glu Gln Glu Cys Leu Asp Gly 675 680
685 Ile Leu Arg Glu Ile Ala Leu Leu Tyr Ile Pro Asp Met Val Pro Lys
690 695 700 Val Asp Thr Leu Asp Ala Ser Leu Ser Glu Asp Glu Lys Ala
Gln Phe 705 710 715 720 Ile Asn Arg Lys Glu His Ile Ser Ser Leu Leu
Glu His Val Leu Phe 725 730 735 Pro Cys Ile Lys Arg Arg Phe Leu Ala
Pro Arg His Ile Leu Lys Asp 740 745 750 Val Val Glu Ile Ala Asn Leu
Pro Asp Leu Tyr Lys Val Phe Glu Arg 755 760 765 Cys <210> SEQ
ID NO 31 <211> LENGTH: 3056 <212> TYPE: DNA <213>
ORGANISM: Mus musculus <400> SEQUENCE: 31 gaattccggt
gaaggtcctg aagaatttcc agattcctga gtatcattgg aggagacaga 60
taacctgtcg tcaggtaacg atggtgtata tgcaacagaa atgggtgttc ctggagacgc
120 gtcttttccc gagagcggca ccgcaactct cccgcggtga ctgtgactgg
aggagtcctg 180 catccatgga gcaaaccgaa ggcgtgagta cagaatgtgc
taaggccatc aagcctattg 240 atgggaagtc agtccatcaa atttgttctg
ggcaggtgat actcagttta agcaccgctg 300 tgaaggagtt gatagaaaat
agtgtagatg ctggtgctac tactattgat ctaaggctta 360 aagactatgg
ggtggacctc attgaagttt cagacaatgg atgtggggta gaagaagaaa 420
actttgaagg tctagctctg aaacatcaca catctaagat tcaagagttt gccgacctca
480 cgcaggttga aactttcggc tttcgggggg aagctctgag ctctctgtgt
gcactaagtg 540 atgtcactat atctacctgc cacgggtctg caagcgttgg
gactcgactg gtgtttgacc 600 ataatgggaa aatcacccag aaaactccct
acccccgacc taaaggaacc acagtcagtg 660 tgcagcactt attttataca
ctacccgtgc gttacaaaga gtttcagagg aacattaaaa 720 aggagtattc
caaaatggtg caggtcttac aggcgtactg tatcatctca gcaggcgtcc 780
gtgtaagctg cactaatcag ctcggacagg ggaagcggca cgctgtggtg tgcacaagcg
840 gcacgtctgg catgaaggaa aatatcgggt ctgtgtttgg ccagaagcag
ttgcaaagcc 900 tcattccttt tgttcagctg ccccctagtg acgctgtgtg
tgaagagtac ggcctgagca 960 cttcaggacg ccacaaaacc ttttctacgt
ttcgggcttc atttcacagt gcacgcacgg 1020 cgccgggagg agtgcaacag
acaggcagtt tttcttcatc aatcagaggc cctgtgaccc 1080 agcaaaggtc
tctaagcttg tcaatgaggt tttatcacat gtataaccgg catcagtacc 1140
catttgtcgt ccttaacgtt tccgttgact cagaatgtgt ggatattaat gtaactccag
1200 ataaaaggca aattctacta caagaagaga agctattgct ggccgtttta
aagacctcct 1260 tgataggaat gtttgacagt gatgcaaaca agcttaatgt
caaccagcag ccactgctag 1320 atgttgaagg taacttagta aagctgcata
ctgcagaact agaaaagcct gtgccaggaa 1380 agcaagataa ctctccttca
ctgaagagca cagcagacga gaaaagggta gcatccatct 1440 ccaggctgag
agaggccttt tctcttcatc ctactaaaga gatcaagtct aggggtccag 1500
agactgctga actgacacgg agttttccaa gtgagaaaag gggcgtgtta tcctcttatc
1560 cttcagacgt catctcttac agaggcctcc gtggctcgca ggacaaattg
gtgagtccca 1620 cggacagccc tggtgactgt atggacagag agaaaataga
aaaagactca gggctcagca 1680 gcacctcagc tggctctgag gaagagttca
gcaccccaga agtggccagt agctttagca 1740 gtgactataa cgtgagctcc
ctagaagaca gaccttctca ggaaaccata aactgtggtg 1800 acctggactg
ccgtcctcca ggtacaggac agtccttgaa gccagaagac catggatatc 1860
aatgcaaagc tctacctcta gctcgtctgt cacccacaaa tgccaagcgc ttcaagacag
1920 aggaaagacc ctcaaatgtc aacatttctc aaagattgcc tggtcctcag
agcacctcag 1980 cagctgaggt cgatgtagcc ataaaaatga ataagagaat
cgtgctcctc gagttctctc 2040
tgagttctct agctaagcga atgaagcagt tacagcacct aaaggcgcag aacaaacatg
2100 aactgagtta cagaaaattt agggccaaga tttgccctgg agaaaaccaa
gcagcagaag 2160 atgaactcag aaaagagatt agtaaatcga tgtttgcaga
gatggagatc ttgggtcagt 2220 ttaacctggg atttatagta accaaactga
aagaggacct cttcctggtg gaccagcatg 2280 ctgcggatga gaagtacaac
tttgagatgc tgcagcagca cacggtgctc caggcgcaga 2340 ggctcatcac
accccagact ctgaacttaa ctgctgtcaa tgaagctgta ctgatagaaa 2400
atctggaaat attcagaaag aatggctttg actttgtcat tgatgaggat gctccagtca
2460 ctgaaagggc taaattgatt tccttaccaa ctagtaaaaa ctggaccttt
ggaccccaag 2520 atatagatga actgatcttt atgttaagtg acagccctgg
ggtcatgtgc cggccctcac 2580 gagtcagaca gatgtttgct tccagagcct
gtcggaagtc agtgatgatt ggaacggcgc 2640 tcaatgcgag cgagatgaag
aagctcatca cccacatggg tgagatggac cacccctgga 2700 actgccccca
cggcaggcca accatgaggc acgttgccaa tctggatgtc atctctcaga 2760
actgacacac cccttgtagc atagagttta ttacagattg ttcggtttgc aaagagaagg
2820 ttttaagtaa tctgattatc gttgtacaaa aattagcatg ctgctttaat
gtactggatc 2880 catttaaaag cagtgttaag gcaggcatga tggagtgttc
ctctagctca gctacttggg 2940 tgatccggtg ggagctcatg tgagcccagg
actttgagac cactccgagc cacattcatg 3000 agactcaatt caaggacaaa
aaaaaaaaga tatttttgaa gccttttaaa aaaaaa 3056 <210> SEQ ID NO
32 <211> LENGTH: 859 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 32 Met Glu Gln Thr Glu
Gly Val Ser Thr Glu Cys Ala Lys Ala Ile Lys 1 5 10 15 Pro Ile Asp
Gly Lys Ser Val His Gln Ile Cys Ser Gly Gln Val Ile 20 25 30 Leu
Ser Leu Ser Thr Ala Val Lys Glu Leu Ile Glu Asn Ser Val Asp 35 40
45 Ala Gly Ala Thr Thr Ile Asp Leu Arg Leu Lys Asp Tyr Gly Val Asp
50 55 60 Leu Ile Glu Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu
Asn Phe 65 70 75 80 Glu Gly Leu Ala Leu Lys His His Thr Ser Lys Ile
Gln Glu Phe Ala 85 90 95 Asp Leu Thr Gln Val Glu Thr Phe Gly Phe
Arg Gly Glu Ala Leu Ser 100 105 110 Ser Leu Cys Ala Leu Ser Asp Val
Thr Ile Ser Thr Cys His Gly Ser 115 120 125 Ala Ser Val Gly Thr Arg
Leu Val Phe Asp His Asn Gly Lys Ile Thr 130 135 140 Gln Lys Thr Pro
Tyr Pro Arg Pro Lys Gly Thr Thr Val Ser Val Gln 145 150 155 160 His
Leu Phe Tyr Thr Leu Pro Val Arg Tyr Lys Glu Phe Gln Arg Asn 165 170
175 Ile Lys Lys Glu Tyr Ser Lys Met Val Gln Val Leu Gln Ala Tyr Cys
180 185 190 Ile Ile Ser Ala Gly Val Arg Val Ser Cys Thr Asn Gln Leu
Gly Gln 195 200 205 Gly Lys Arg His Ala Val Val Cys Thr Ser Gly Thr
Ser Gly Met Lys 210 215 220 Glu Asn Ile Gly Ser Val Phe Gly Gln Lys
Gln Leu Gln Ser Leu Ile 225 230 235 240 Pro Phe Val Gln Leu Pro Pro
Ser Asp Ala Val Cys Glu Glu Tyr Gly 245 250 255 Leu Ser Thr Ser Gly
Arg His Lys Thr Phe Ser Thr Phe Arg Ala Ser 260 265 270 Phe His Ser
Ala Arg Thr Ala Pro Gly Gly Val Gln Gln Thr Gly Ser 275 280 285 Phe
Ser Ser Ser Ile Arg Gly Pro Val Thr Gln Gln Arg Ser Leu Ser 290 295
300 Leu Ser Met Arg Phe Tyr His Met Tyr Asn Arg His Gln Tyr Pro Phe
305 310 315 320 Val Val Leu Asn Val Ser Val Asp Ser Glu Cys Val Asp
Ile Asn Val 325 330 335 Thr Pro Asp Lys Arg Gln Ile Leu Leu Gln Glu
Glu Lys Leu Leu Leu 340 345 350 Ala Val Leu Lys Thr Ser Leu Ile Gly
Met Phe Asp Ser Asp Ala Asn 355 360 365 Lys Leu Asn Val Asn Gln Gln
Pro Leu Leu Asp Val Glu Gly Asn Leu 370 375 380 Val Lys Leu His Thr
Ala Glu Leu Glu Lys Pro Val Pro Gly Lys Gln 385 390 395 400 Asp Asn
Ser Pro Ser Leu Lys Ser Thr Ala Asp Glu Lys Arg Val Ala 405 410 415
Ser Ile Ser Arg Leu Arg Glu Ala Phe Ser Leu His Pro Thr Lys Glu 420
425 430 Ile Lys Ser Arg Gly Pro Glu Thr Ala Glu Leu Thr Arg Ser Phe
Pro 435 440 445 Ser Glu Lys Arg Gly Val Leu Ser Ser Tyr Pro Ser Asp
Val Ile Ser 450 455 460 Tyr Arg Gly Leu Arg Gly Ser Gln Asp Lys Leu
Val Ser Pro Thr Asp 465 470 475 480 Ser Pro Gly Asp Cys Met Asp Arg
Glu Lys Ile Glu Lys Asp Ser Gly 485 490 495 Leu Ser Ser Thr Ser Ala
Gly Ser Glu Glu Glu Phe Ser Thr Pro Glu 500 505 510 Val Ala Ser Ser
Phe Ser Ser Asp Tyr Asn Val Ser Ser Leu Glu Asp 515 520 525 Arg Pro
Ser Gln Glu Thr Ile Asn Cys Gly Asp Leu Asp Cys Arg Pro 530 535 540
Pro Gly Thr Gly Gln Ser Leu Lys Pro Glu Asp His Gly Tyr Gln Cys 545
550 555 560 Lys Ala Leu Pro Leu Ala Arg Leu Ser Pro Thr Asn Ala Lys
Arg Phe 565 570 575 Lys Thr Glu Glu Arg Pro Ser Asn Val Asn Ile Ser
Gln Arg Leu Pro 580 585 590 Gly Pro Gln Ser Thr Ser Ala Ala Glu Val
Asp Val Ala Ile Lys Met 595 600 605 Asn Lys Arg Ile Val Leu Leu Glu
Phe Ser Leu Ser Ser Leu Ala Lys 610 615 620 Arg Met Lys Gln Leu Gln
His Leu Lys Ala Gln Asn Lys His Glu Leu 625 630 635 640 Ser Tyr Arg
Lys Phe Arg Ala Lys Ile Cys Pro Gly Glu Asn Gln Ala 645 650 655 Ala
Glu Asp Glu Leu Arg Lys Glu Ile Ser Lys Ser Met Phe Ala Glu 660 665
670 Met Glu Ile Leu Gly Gln Phe Asn Leu Gly Phe Ile Val Thr Lys Leu
675 680 685 Lys Glu Asp Leu Phe Leu Val Asp Gln His Ala Ala Asp Glu
Lys Tyr 690 695 700 Asn Phe Glu Met Leu Gln Gln His Thr Val Leu Gln
Ala Gln Arg Leu 705 710 715 720 Ile Thr Pro Gln Thr Leu Asn Leu Thr
Ala Val Asn Glu Ala Val Leu 725 730 735 Ile Glu Asn Leu Glu Ile Phe
Arg Lys Asn Gly Phe Asp Phe Val Ile 740 745 750 Asp Glu Asp Ala Pro
Val Thr Glu Arg Ala Lys Leu Ile Ser Leu Pro 755 760 765 Thr Ser Lys
Asn Trp Thr Phe Gly Pro Gln Asp Ile Asp Glu Leu Ile 770 775 780 Phe
Met Leu Ser Asp Ser Pro Gly Val Met Cys Arg Pro Ser Arg Val 785 790
795 800 Arg Gln Met Phe Ala Ser Arg Ala Cys Arg Lys Ser Val Met Ile
Gly 805 810 815 Thr Ala Leu Asn Ala Ser Glu Met Lys Lys Leu Ile Thr
His Met Gly 820 825 830 Glu Met Asp His Pro Trp Asn Cys Pro His Gly
Arg Pro Thr Met Arg 835 840 845 His Val Ala Asn Leu Asp Val Ile Ser
Gln Asn 850 855 <210> SEQ ID NO 33 <211> LENGTH: 399
<212> TYPE: DNA <213> ORGANISM: Mus musculus
<400> SEQUENCE: 33 atggagcaaa ccgaaggcgt gagtacagaa
tgtgctaagg ccatcaagcc tattgatggg 60 aagtcagtcc atcaaatttg
ttctgggcag gtgatactca gtttaagcac cgctgtgaag 120 gagttgatag
aaaatagtgt agatgctggt gctactacta ttgatctaag gcttaaagac 180
tatggggtgg acctcattga agtttcagac aatggatgtg gggtagaaga agaaaacttt
240 gaaggtctag ctctgaaaca tcacacatct aagattcaag agtttgccga
cctcacgcag 300 gttgaaactt tcggctttcg gggggaagct ctgagctctc
tgtgtgcact aagtgatgtc 360 actatatcta cctgccacgg gtctgcaagc
gttgggact 399 <210> SEQ ID NO 34 <211> LENGTH: 133
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 34 Met Glu Gln Thr Glu Gly Val Ser Thr Glu
Cys Ala Lys Ala Ile Lys 1 5 10 15 Pro Ile Asp Gly Lys Ser Val His
Gln Ile Cys Ser Gly Gln Val Ile 20 25 30 Leu Ser Leu Ser Thr Ala
Val Lys Glu Leu Ile Glu Asn Ser Val Asp 35 40 45 Ala Gly Ala Thr
Thr Ile Asp Leu Arg Leu Lys Asp Tyr Gly Val Asp 50 55 60 Leu Ile
Glu Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu Asn Phe 65 70 75 80
Glu Gly Leu Ala Leu Lys His His Thr Ser Lys Ile Gln Glu Phe Ala 85
90 95 Asp Leu Thr Gln Val Glu Thr Phe Gly Phe Arg Gly Glu Ala Leu
Ser 100 105 110 Ser Leu Cys Ala Leu Ser Asp Val Thr Ile Ser Thr Cys
His Gly Ser 115 120 125 Ala Ser Val Gly Thr 130
<210> SEQ ID NO 35 <211> LENGTH: 3099 <212> TYPE:
DNA <213> ORGANISM: Arabidopsis thaliana <400>
SEQUENCE: 35 gtcttcttct tcatccttgt ctcaccttcg attttggcgg caaaacataa
accctaaggg 60 ttttctcact ctctctctct cttctcacac acacagtccc
agagtacggt ggtgttgatt 120 cgattgagga gattcatctg tttatagggt
ttagcaaatg caaggagatt cttctccgtc 180 tccgacgact actagctctc
ctttgataag acctataaac agaaacgtaa ttcacagaat 240 ctgttccggt
caagtcatct tagacctctc ttcggccgtc aaggagcttg tcgagaatag 300
tctcgacgcc ggcgccacca gtatagagat taacctccga gactacggcg aagactattt
360 tcaggtcatt gacaatggtt gtggcatttc cccaaccaat ttcaaggttc
ttgcacttaa 420 gcatcatact tctaaattag aggatttcac agatcttttg
aatttgacta cttatggttt 480 tagaggagaa gccttgagct ctctctgtgc
attgggaaat ctcactgtgg aaacaagaac 540 aaagaatgag ccagttgcta
cgctcttgac gtttgatcat tctggtttgc ttactgctga 600 aaagaagact
gctcgccaaa ttggtaccac tgtcactgtt aggaagttgt tctctaattt 660
acctgtacga agcaaagagt ttaagcggaa tatacgcaaa gaatatggga agcttgtatc
720 tttattgaac gcatatgcgc ttattgcgaa aggagtgcgg tttgtctgct
ctaacacgac 780 tgggaaaaac ccaaagtctg ttgtgctgaa cacacaaggg
aggggttcac ttaaagataa 840 tatcataaca gttttcggca ttagtacctt
tacaagtcta cagcctgtaa gtatatgtgt 900 atcagaagat tgtagagttg
aagggtttct ttccaagcct ggacagggta ctggacgcaa 960 tttagcagat
cgacagtatt tctttataaa tggtcggcct gtagatatgc caaaagtcag 1020
caagttggtg aatgagttat ataaagatac aagttctcgg aaatatccag ttaccattct
1080 ggattttatt gtgcctggtg gagcatgtga tttgaatgtc acgcccgata
aaagaaaggt 1140 gttcttttct gacgagactt ctgttatcgg ttctttgagg
gaaggtctga acgagatata 1200 ttcctccagt aatgcgtctt atattgttaa
taggttcgag gagaattcgg agcaaccaga 1260 taaggctgga gtttcgtcgt
ttcagaagaa atcaaatctt ttgtcagaag ggatagttct 1320 ggatgtcagt
tctaaaacaa gactagggga agctattgag aaagaaaatc catccttaag 1380
ggaggttgaa attgataata gttcgccaat ggagaagttt aagtttgaga tcaaggcatg
1440 tgggacgaag aaaggggaag gttctttatc agtccatgat gtaactcacc
ttgacaagac 1500 acctagcaaa ggtttgcctc agttaaatgt gactgagaaa
gttactgatg caagtaaaga 1560 cttgagcagc cgctctagct ttgcccagtc
aactttgaat acttttgtta ccatgggaaa 1620 aagaaaacat gaaaacataa
gcaccatcct ctctgaaaca cctgtcctca gaaaccaaac 1680 ttctagttat
cgtgtggaga aaagcaaatt tgaagttcgt gccttagctt caaggtgtct 1740
cgtggaaggc gatcaacttg atgatatggt catctcaaag gaagatatga caccaagcga
1800 aagagattct gaactaggca atcggatttc tcctggaaca caagctgata
atgttgaaag 1860 acatgagaga gaacatgaaa agcctataag gtttgaagaa
ccaacatcag ataacacact 1920 caccaagggg gatgtggaaa gggtttcaga
ggacaatcca cggtgcagtc agccactgcg 1980 atctgtggcc acagtgctgg
attccccagc tcagtcaacc ggtcctaaaa tgttttccac 2040 attagaattt
agtttccaaa acctcaggac aaggaggtta gagaggctgt cgagattgca 2100
gtccacaggt tatgtatcta aatgtatgaa tacgccacag cctaaaaagt gctttgccgc
2160 tgcaacatta gagttatctc aaccggatga tgaagagcga aaagcaaggg
ctttagctgc 2220 agctacttct gagctggaaa ggctttttcg aaaagaggat
ttcaggagaa tgcaggtact 2280 cgggcaattc aatcttgggt tcatcattgc
aaaattggag cgagatctgt tcattgtgga 2340 tcagcatgca gctgatgaga
aattcaactt cgaacattta gcaaggtcaa ctgtcctgaa 2400 ccagcaaccc
ttactccagc ctttgaactt ggaactctct ccagaagaag aagtaactgt 2460
gttaatgcac atggatatta tcagggaaaa tggctttctt ctagaggaga atccaagtgc
2520 tcctcccgga aaacacttta gactacgagc cattccttat agcaagaata
tcacctttgg 2580 agtcgaagat cttaaagacc tgatctcaac tctaggagat
aaccatgggg aatgttcggt 2640 tgctagtagc tacaaaacca gcaaaacaga
ttcgatttgt ccatcacgag tccgtgcaat 2700 gctagcatcc cgagcatgca
gatcatctgt gatgatcgga gatccactca gaaaaaacga 2760 aatgcagaag
atagtagaac acttggcaga tctcgaatct ccttggaatt gcccacacgg 2820
acgaccaaca atgcgtcatc ttgtggactt gacaacttta ctcacattac ctgatgacga
2880 caatgtcaat gatgatgatg atgatgatgc aaccatctca ttggcatgaa
cactcaaaag 2940 tcttaacgta tttagatgtg agaatcctta agattaacat
tgaggaacac tcggttataa 3000 ctacaatcgt aaatgtaaat tgtcttagtc
tatatgatct ttttggtcac aacaggtaat 3060 ttcattttcc tttgattact
tctcgtgaaa aaacaaatt 3099 <210> SEQ ID NO 36 <211>
LENGTH: 923 <212> TYPE: PRT <213> ORGANISM: Arabidopsis
thaliana <400> SEQUENCE: 36 Met Gln Gly Asp Ser Ser Pro Ser
Pro Thr Thr Thr Ser Ser Pro Leu 1 5 10 15 Ile Arg Pro Ile Asn Arg
Asn Val Ile His Arg Ile Cys Ser Gly Gln 20 25 30 Val Ile Leu Asp
Leu Ser Ser Ala Val Lys Glu Leu Val Glu Asn Ser 35 40 45 Leu Asp
Ala Gly Ala Thr Ser Ile Glu Ile Asn Leu Arg Asp Tyr Gly 50 55 60
Glu Asp Tyr Phe Gln Val Ile Asp Asn Gly Cys Gly Ile Ser Pro Thr 65
70 75 80 Asn Phe Lys Val Leu Ala Leu Lys His His Thr Ser Lys Leu
Glu Asp 85 90 95 Phe Thr Asp Leu Leu Asn Leu Thr Thr Tyr Gly Phe
Arg Gly Glu Ala 100 105 110 Leu Ser Ser Leu Cys Ala Leu Gly Asn Leu
Thr Val Glu Thr Arg Thr 115 120 125 Lys Asn Glu Pro Val Ala Thr Leu
Leu Thr Phe Asp His Ser Gly Leu 130 135 140 Leu Thr Ala Glu Lys Lys
Thr Ala Arg Gln Ile Gly Thr Thr Val Thr 145 150 155 160 Val Arg Lys
Leu Phe Ser Asn Leu Pro Val Arg Ser Lys Glu Phe Lys 165 170 175 Arg
Asn Ile Arg Lys Glu Tyr Gly Lys Leu Val Ser Leu Leu Asn Ala 180 185
190 Tyr Ala Leu Ile Ala Lys Gly Val Arg Phe Val Cys Ser Asn Thr Thr
195 200 205 Gly Lys Asn Pro Lys Ser Val Val Leu Asn Thr Gln Gly Arg
Gly Ser 210 215 220 Leu Lys Asp Asn Ile Ile Thr Val Phe Gly Ile Ser
Thr Phe Thr Ser 225 230 235 240 Leu Gln Pro Val Ser Ile Cys Val Ser
Glu Asp Cys Arg Val Glu Gly 245 250 255 Phe Leu Ser Lys Pro Gly Gln
Gly Thr Gly Arg Asn Leu Ala Asp Arg 260 265 270 Gln Tyr Phe Phe Ile
Asn Gly Arg Pro Val Asp Met Pro Lys Val Ser 275 280 285 Lys Leu Val
Asn Glu Leu Tyr Lys Asp Thr Ser Ser Arg Lys Tyr Pro 290 295 300 Val
Thr Ile Leu Asp Phe Ile Val Pro Gly Gly Ala Cys Asp Leu Asn 305 310
315 320 Val Thr Pro Asp Lys Arg Lys Val Phe Phe Ser Asp Glu Thr Ser
Val 325 330 335 Ile Gly Ser Leu Arg Glu Gly Leu Asn Glu Ile Tyr Ser
Ser Ser Asn 340 345 350 Ala Ser Tyr Ile Val Asn Arg Phe Glu Glu Asn
Ser Glu Gln Pro Asp 355 360 365 Lys Ala Gly Val Ser Ser Phe Gln Lys
Lys Ser Asn Leu Leu Ser Glu 370 375 380 Gly Ile Val Leu Asp Val Ser
Ser Lys Thr Arg Leu Gly Glu Ala Ile 385 390 395 400 Glu Lys Glu Asn
Pro Ser Leu Arg Glu Val Glu Ile Asp Asn Ser Ser 405 410 415 Pro Met
Glu Lys Phe Lys Phe Glu Ile Lys Ala Cys Gly Thr Lys Lys 420 425 430
Gly Glu Gly Ser Leu Ser Val His Asp Val Thr His Leu Asp Lys Thr 435
440 445 Pro Ser Lys Gly Leu Pro Gln Leu Asn Val Thr Glu Lys Val Thr
Asp 450 455 460 Ala Ser Lys Asp Leu Ser Ser Arg Ser Ser Phe Ala Gln
Ser Thr Leu 465 470 475 480 Asn Thr Phe Val Thr Met Gly Lys Arg Lys
His Glu Asn Ile Ser Thr 485 490 495 Ile Leu Ser Glu Thr Pro Val Leu
Arg Asn Gln Thr Ser Ser Tyr Arg 500 505 510 Val Glu Lys Ser Lys Phe
Glu Val Arg Ala Leu Ala Ser Arg Cys Leu 515 520 525 Val Glu Gly Asp
Gln Leu Asp Asp Met Val Ile Ser Lys Glu Asp Met 530 535 540 Thr Pro
Ser Glu Arg Asp Ser Glu Leu Gly Asn Arg Ile Ser Pro Gly 545 550 555
560 Thr Gln Ala Asp Asn Val Glu Arg His Glu Arg Glu His Glu Lys Pro
565 570 575 Ile Arg Phe Glu Glu Pro Thr Ser Asp Asn Thr Leu Thr Lys
Gly Asp 580 585 590 Val Glu Arg Val Ser Glu Asp Asn Pro Arg Cys Ser
Gln Pro Leu Arg 595 600 605 Ser Val Ala Thr Val Leu Asp Ser Pro Ala
Gln Ser Thr Gly Pro Lys 610 615 620 Met Phe Ser Thr Leu Glu Phe Ser
Phe Gln Asn Leu Arg Thr Arg Arg 625 630 635 640 Leu Glu Arg Leu Ser
Arg Leu Gln Ser Thr Gly Tyr Val Ser Lys Cys 645 650 655 Met Asn Thr
Pro Gln Pro Lys Lys Cys Phe Ala Ala Ala Thr Leu Glu 660 665 670 Leu
Ser Gln Pro Asp Asp Glu Glu Arg Lys Ala Arg Ala Leu Ala Ala 675 680
685 Ala Thr Ser Glu Leu Glu Arg Leu Phe Arg Lys Glu Asp Phe Arg Arg
690 695 700 Met Gln Val Leu Gly Gln Phe Asn Leu Gly Phe Ile Ile Ala
Lys Leu 705 710 715 720 Glu Arg Asp Leu Phe Ile Val Asp Gln His Ala
Ala Asp Glu Lys Phe 725 730 735 Asn Phe Glu His Leu Ala Arg Ser Thr
Val Leu Asn Gln Gln Pro Leu
740 745 750 Leu Gln Pro Leu Asn Leu Glu Leu Ser Pro Glu Glu Glu Val
Thr Val 755 760 765 Leu Met His Met Asp Ile Ile Arg Glu Asn Gly Phe
Leu Leu Glu Glu 770 775 780 Asn Pro Ser Ala Pro Pro Gly Lys His Phe
Arg Leu Arg Ala Ile Pro 785 790 795 800 Tyr Ser Lys Asn Ile Thr Phe
Gly Val Glu Asp Leu Lys Asp Leu Ile 805 810 815 Ser Thr Leu Gly Asp
Asn His Gly Glu Cys Ser Val Ala Ser Ser Tyr 820 825 830 Lys Thr Ser
Lys Thr Asp Ser Ile Cys Pro Ser Arg Val Arg Ala Met 835 840 845 Leu
Ala Ser Arg Ala Cys Arg Ser Ser Val Met Ile Gly Asp Pro Leu 850 855
860 Arg Lys Asn Glu Met Gln Lys Ile Val Glu His Leu Ala Asp Leu Glu
865 870 875 880 Ser Pro Trp Asn Cys Pro His Gly Arg Pro Thr Met Arg
His Leu Val 885 890 895 Asp Leu Thr Thr Leu Leu Thr Leu Pro Asp Asp
Asp Asn Val Asn Asp 900 905 910 Asp Asp Asp Asp Asp Ala Thr Ile Ser
Leu Ala 915 920 <210> SEQ ID NO 37 <211> LENGTH: 399
<212> TYPE: DNA <213> ORGANISM: Arabidopsis thaliana
<400> SEQUENCE: 37 atgcaaggag attcttctcc gtctccgacg
actactagct ctcctttgat aagacctata 60 aacagaaacg taattcacag
aatctgttcc ggtcaagtca tcttagacct ctcttcggcc 120 gtcaaggagc
ttgtcgagaa tagtctcgac gccggcgcca ccagtataga gattaacctc 180
cgagactacg gcgaagacta ttttcaggtc attgacaatg gttgtggcat ttccccaacc
240 aatttcaagg ttcttgcact taagcatcat acttctaaat tagaggattt
cacagatctt 300 ttgaatttga ctacttatgg ttttagagga gaagccttga
gctctctctg tgcattggga 360 aatctcactg tggaaacaag aacaaagaat
gagccagtt 399 <210> SEQ ID NO 38 <211> LENGTH: 133
<212> TYPE: PRT <213> ORGANISM: Arabidopsis thaliana
<400> SEQUENCE: 38 Met Gln Gly Asp Ser Ser Pro Ser Pro Thr
Thr Thr Ser Ser Pro Leu 1 5 10 15 Ile Arg Pro Ile Asn Arg Asn Val
Ile His Arg Ile Cys Ser Gly Gln 20 25 30 Val Ile Leu Asp Leu Ser
Ser Ala Val Lys Glu Leu Val Glu Asn Ser 35 40 45 Leu Asp Ala Gly
Ala Thr Ser Ile Glu Ile Asn Leu Arg Asp Tyr Gly 50 55 60 Glu Asp
Tyr Phe Gln Val Ile Asp Asn Gly Cys Gly Ile Ser Pro Thr 65 70 75 80
Asn Phe Lys Val Leu Ala Leu Lys His His Thr Ser Lys Leu Glu Asp 85
90 95 Phe Thr Asp Leu Leu Asn Leu Thr Thr Tyr Gly Phe Arg Gly Glu
Ala 100 105 110 Leu Ser Ser Leu Cys Ala Leu Gly Asn Leu Thr Val Glu
Thr Arg Thr 115 120 125 Lys Asn Glu Pro Val 130 <210> SEQ ID
NO 39 <211> LENGTH: 2791 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (77)..(673) <300> PUBLICATION
INFORMATION: <308> DATABASE ACCESSION NUMBER: NM_02661
<309> DATABASE ENTRY DATE: 2003-12-13 <313> RELEVANT
RESIDUES IN SEQ ID NO: (1)..(2791) <400> SEQUENCE: 39
gaaccatcat taattgaagt gagatttttc tggcctgaga cttgcaggga ggcaagaaga
60 cactctggac accact atg gac agc ctc ttg atg aac cgg agg aag ttt
ctt 112 Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu 1 5 10 tac
caa ttc aaa aat gtc cgc tgg gct aag ggt cgg cgt gag acc tac 160 Tyr
Gln Phe Lys Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr 15 20
25 ctg tgc tac gta gtg aag agg cgt gac agt gct aca tcc ttt tca ctg
208 Leu Cys Tyr Val Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu
30 35 40 gac ttt ggt tat ctt cgc aat aag aac ggc tgc cac gtg gaa
ttg ctc 256 Asp Phe Gly Tyr Leu Arg Asn Lys Asn Gly Cys His Val Glu
Leu Leu 45 50 55 60 ttc ctc cgc tac atc tcg gac tgg gac cta gac cct
ggc cgc tgc tac 304 Phe Leu Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro
Gly Arg Cys Tyr 65 70 75 cgc gtc acc tgg ttc acc tcc tgg agc ccc
tgc tac gac tgt gcc cga 352 Arg Val Thr Trp Phe Thr Ser Trp Ser Pro
Cys Tyr Asp Cys Ala Arg 80 85 90 cat gtg gcc gac ttt ctg cga ggg
aac ccc aac ctc agt ctg agg atc 400 His Val Ala Asp Phe Leu Arg Gly
Asn Pro Asn Leu Ser Leu Arg Ile 95 100 105 ttc acc gcg cgc ctc tac
ttc tgt gag gac cgc aag gct gag ccc gag 448 Phe Thr Ala Arg Leu Tyr
Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu 110 115 120 ggg ctg cgg cgg
ctg cac cgc gcc ggg gtg caa ata gcc atc atg acc 496 Gly Leu Arg Arg
Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr 125 130 135 140 ttc
aaa gat tat ttt tac tgc tgg aat act ttt gta gaa aac cat gaa 544 Phe
Lys Asp Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu 145 150
155 aga act ttc aaa gcc tgg gaa ggg ctg cat gaa aat tca gtt cgt ctc
592 Arg Thr Phe Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu
160 165 170 tcc aga cag ctt cgg cgc atc ctt ttg ccc ctg tat gag gtt
gat gac 640 Ser Arg Gln Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val
Asp Asp 175 180 185 tta cga gac gca ttt cgt act ttg gga ctt tga
tagcaacttc caggaatgtc 693 Leu Arg Asp Ala Phe Arg Thr Leu Gly Leu
190 195 acacacgatg aaatatctct gctgaagaca gtggataaaa aacagtcctt
caagtcttct 753 ctgtttttat tcttcaactc tcactttctt agagtttaca
gaaaaaatat ttatatacga 813 ctctttaaaa agatctatgt cttgaaaata
gagaaggaac acaggtctgg ccagggacgt 873 gctgcaattg gtgcagtttt
gaatgcaaca ttgtccccta ctgggaataa cagaactgca 933 ggacctggga
gcatcctaaa gtgtcaacgt ttttctatga cttttaggta ggatgagagc 993
agaaggtaga tcctaaaaag catggtgaga ggatcaaatg tttttatatc aacatccttt
1053 attatttgat tcatttgagt taacagtggt gttagtgata gatttttcta
ttcttttccc 1113 ttgacgttta ctttcaagta acacaaactc ttccatcagg
ccatgatcta taggacctcc 1173 taatgagagt atctgggtga ttgtgacccc
aaaccatctc tccaaagcat taatatccaa 1233 tcatgcgctg tatgttttaa
tcagcagaag catgttttta tgtttgtaca aaagaagatt 1293 gttatgggtg
gggatggagg tatagaccat gcatggtcac cttcaagcta ctttaataaa 1353
ggatcttaaa atgggcagga ggactgtgaa caagacaccc taataatggg ttgatgtctg
1413 aagtagcaaa tcttctggaa acgcaaactc ttttaaggaa gtccctaatt
tagaaacacc 1473 cacaaacttc acatatcata attagcaaac aattggaagg
aagttgcttg aatgttgggg 1533 agaggaaaat ctattggctc tcgtgggtct
cttcatctca gaaatgccaa tcaggtcaag 1593 gtttgctaca ttttgtatgt
gtgtgatgct tctcccaaag gtatattaac tatataagag 1653 agttgtgaca
aaacagaatg ataaagctgc gaaccgtggc acacgctcat agttctagct 1713
gcttgggagg ttgaggaggg aggatggctt gaacacaggt gttcaaggcc agcctgggca
1773 acataacaag atcctgtctc tcaaaaaaaa aaaaaaaaaa aagaaagaga
gagggccggg 1833 cgtggtggct cacgcctgta atcccagcac tttgggaggc
cgagccgggc ggatcacctg 1893 tggtcaggag tttgagacca gcctggccaa
catggcaaaa ccccgtctgt actcaaaatg 1953 caaaaattag ccaggcgtgg
tagcaggcac ctgtaatccc agctacttgg gaggctgagg 2013 caggagaatc
gcttgaaccc aggaggtgga ggttgcagta agctgagatc gtgccgttgc 2073
actccagcct gggcgacaag agcaagactc tgtctcagaa aaaaaaaaaa aaaagagaga
2133 gagagagaaa gagaacaata tttgggagag aaggatgggg aagcattgca
aggaaattgt 2193 gctttatcca acaaaatgta aggagccaat aagggatccc
tatttgtctc ttttggtgtc 2253 tatttgtccc taacaactgt ctttgacagt
gagaaaaata ttcagaataa ccatatccct 2313 gtgccgttat tacctagcaa
cccttgcaat gaagatgagc agatccacag gaaaacttga 2373 atgcacaact
gtcttatttt aatcttattg tacataagtt tgtaaaagag ttaaaaattg 2433
ttacttcatg tattcattta tattttatat tattttgcgt ctaatgattt tttattaaca
2493 tgatttcctt ttctgatata ttgaaatgga gtctcaaagc ttcataaatt
tataacttta 2553 gaaatgattc taataacaac gtatgtaatt gtaacattgc
agtaatggtg ctacgaagcc 2613 atttctcttg atttttagta aacttttatg
acagcaaatt tgcttctggc tcactttcaa 2673 tcagttaaat aaatgataaa
taattttgga agctgtgaag ataaaatacc aaataaaata 2733 atataaaagt
gatttatatg aagttaaaat aaaaaatcag tatgatggaa taaacttg 2791
<210> SEQ ID NO 40 <211> LENGTH: 198 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 40 Met
Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 1 5 10
15 Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val
20 25 30 Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe
Gly Tyr 35 40 45 Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu
Phe Leu Arg Tyr 50 55 60 Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg
Cys Tyr Arg Val Thr Trp 65 70 75 80 Phe Thr Ser Trp Ser Pro Cys Tyr
Asp Cys Ala Arg His Val Ala Asp
85 90 95 Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr
Ala Arg 100 105 110 Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu
Gly Leu Arg Arg 115 120 125 Leu His Arg Ala Gly Val Gln Ile Ala Ile
Met Thr Phe Lys Asp Tyr 130 135 140 Phe Tyr Cys Trp Asn Thr Phe Val
Glu Asn His Glu Arg Thr Phe Lys 145 150 155 160 Ala Trp Glu Gly Leu
His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 165 170 175 Arg Arg Ile
Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 180 185 190 Phe
Arg Thr Leu Gly Leu 195 <210> SEQ ID NO 41 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Oligonucleotide primer sequence <400> SEQUENCE: 41 atggacagcc
tcttgatgaa 20 <210> SEQ ID NO 42 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Oligonucleotide
primer sequence <400> SEQUENCE: 42 caggctttga aagttctttc 20
<210> SEQ ID NO 43 <211> LENGTH: 2440 <212> TYPE:
DNA <213> ORGANISM: Mus musculus <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(2413)..(2413) <223> OTHER INFORMATION: n is a, c, g, or t
<400> SEQUENCE: 43 ggcacgagca gcactgaagc agccttgctt
gaagcaagct tcctttggcc taagactttg 60 agggagtcaa gaaagtcacg
ctggagaccg atatggacag ccttctgatg aagcaaaaga 120 agtttcttta
ccatttcaaa aatgtccgct gggccaaggg acggcatgag acctacctct 180
gctacgtggt gaagaggaga gatagtgcca cctcctgctc actggacttc ggccaccttc
240 gcaacaagtc tggctgccac gtggaattgt tgttcctacg ctacatctca
gactgggacc 300 tggacccggg ccggtgttac cgcgtcacct ggttcacctc
ctggagcccg tgctatgact 360 gtgcccggca cgtggctgag tttctgagat
ggaaccctaa cctcagcctg aggattttca 420 ccgcgcgcct ctacttctgt
gaagaccgca aggctgagcc tgaggggctg cggagactgc 480 accgcgctgg
ggtccagatc gggatcatga ccttcaaaga ctatttttac tgctggaata 540
catttgtaga aaatcgtgaa agaactttca aagcctggga agggctacat gaaaattctg
600 tccggctaac cagacaactt cggcgcatcc ttttgccctt gtacgaagtc
gatgacttgc 660 gagatgcatt tcgtatgttg ggattttgaa agcaacctcc
tggaatgtca cacgtgatga 720 aatttctctg aagagactgg atagaaaaac
aacccttcaa ctacatgttt ttcttcttaa 780 gtactcactt ttataagtgt
agggggaaat tatatgactt tttaaaaaat acttgagctg 840 cacaggaccg
ccagagcaat gatgtaactg agcttgctgt gcaacatcgc catctactgg 900
ggaacagcat aacttccaga ctttgggtcg tgaatgatgc tctttttttt caacagcatg
960 gaaaagcata tggagacgac cacacagttt gttacaccca ccctgtgttc
cttgattcat 1020 ttgaattctc aggggtatca gtgacggatt cttctattct
ttccctctaa ggctcacttt 1080 caggggtcct tttctgacaa ggtcacgggg
ctgtcctaca gtctctgtct gagcaatcac 1140 aagccattct ctcaaaaaca
ttaatactca ggcacatgct gtatgttttc actgtccgtc 1200 gtgtttttca
catttgtatg tgaaagggct tggggtggga tttgaagaat gcacgatcgc 1260
ctctgggtga tttcaataaa ggatcttaaa atgcagatga ggactacgaa gaaatcactc
1320 tgaaaatgag ttcacgcctc aagaagcaaa tcccctggaa acacagactc
tttttcattt 1380 ttaatgtcat tagtttactc acagtcttat caagaagaag
agttcaaggg ttcaacccaa 1440 ttttcagatc gcgtccctta aacatcagta
attctgttaa agggatcaaa catccttatt 1500 tcttaactaa ctggtgcctt
gctgtagaga aaggagcaaa gcgcccagat ccaaagtata 1560 tagttatcat
agccaggaac cgctactcgt tttccattac aaatggcaaa ttcttccccg 1620
ggctctcctc atagtgcctg agacggacca cggaggtgat gaacctccgg attctctggc
1680 ccaacacggt ggaagctctg caagggcgca gagacagaat gcggcagaaa
ttgcccccga 1740 gtcccaactc tcctttcctt gcgaccttgg gaacaagact
taaaggagcc tgtgacttag 1800 aaacttctag taatgggtac ctgggagtcg
tttgagtatg gggcagtgat ttattctctg 1860 tgatggatgc caacacggtt
aaacagaatt tttagttttt atatgtgtgt gatgctgctc 1920 ccccaaattg
ttaactgtgt aagagggtgg caaaataggg aaagtggcat tcacctatag 1980
ttccagcatt caggaagctg aggcaggagg attgtaaatt tgaggccagt ctgagctgta
2040 aggtgagacc ctatttcaaa caacacagcc agaattgggt tctggtaaat
catacttaac 2100 aagggaaaaa tgcaagacgc aagaccgtgg caaggaaatg
acgctttgcc caacgaaatg 2160 taggaaacca acatagactc ccagtttgtc
cctctttatg tctggtctcc ctaacaacga 2220 tctttgctaa tgagaaaaat
attagaaaaa aatatccctg tgcaattatc acccagtcgc 2280 cattataatg
caattaaaag gcccacaaga aatcctgtat acacgaccgt tatttattgt 2340
atgtaagttg ctgaggaaga ggagaaaaaa ataaagatca tccattcctt cctgcaaaaa
2400 aaaaaaaaaa aanaaaaaaa aaaaaaaaaa aaaaaaaaaa 2440 <210>
SEQ ID NO 44 <211> LENGTH: 198 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 44 Met Asp
Ser Leu Leu Met Lys Gln Lys Lys Phe Leu Tyr His Phe Lys 1 5 10 15
Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 20
25 30 Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly
His 35 40 45 Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe
Leu Arg Tyr 50 55 60 Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys
Tyr Arg Val Thr Trp 65 70 75 80 Phe Thr Ser Trp Ser Pro Cys Tyr Asp
Cys Ala Arg His Val Ala Glu 85 90 95 Phe Leu Arg Trp Asn Pro Asn
Leu Ser Leu Arg Ile Phe Thr Ala Arg 100 105 110 Leu Tyr Phe Cys Glu
Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 115 120 125 Leu His Arg
Ala Gly Val Gln Ile Gly Ile Met Thr Phe Lys Asp Tyr 130 135 140 Phe
Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Arg Thr Phe Lys 145 150
155 160 Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln
Leu 165 170 175 Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu
Arg Asp Ala 180 185 190 Phe Arg Met Leu Gly Phe 195 <210> SEQ
ID NO 45 <211> LENGTH: 24 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Oligonucleotide primer sequence <400>
SEQUENCE: 45 ggattttcag gtgcagattt tcag 24 <210> SEQ ID NO 46
<211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Oligonucleotide primer sequence <400> SEQUENCE:
46 actggatggt gggaagatgg a 21 <210> SEQ ID NO 47 <211>
LENGTH: 19 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Oligonucleotide primer sequence <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (2)..(2) <223>
OTHER INFORMATION: n = g or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (5)..(5) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (6)..(6)
<223> OTHER INFORMATION: n = a or c <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (11)..(11)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: n = c or g <400>
SEQUENCE: 47 angtnnagct ncagnagtc 19 <210> SEQ ID NO 48
<211> LENGTH: 19 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Oligonucleotide primer sequence
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: n is a, c, g, or
t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: n = a
or g <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: n =
g or a <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (18)..(18) <223> OTHER INFORMATION: n =
a or t <400> SEQUENCE: 48 tnccttgncc ccagtannc 19 <210>
SEQ ID NO 49 <211> LENGTH: 19 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Oligonucleotide primer sequence
<400> SEQUENCE: 49 tttcgcaacg ggtttgccg 19 <210> SEQ ID
NO 50 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Oligonucleotide primer sequence <400>
SEQUENCE: 50 gtttcagagt taagccttcg 20 <210> SEQ ID NO 51
<211> LENGTH: 13 <212> TYPE: DNA <213> ORGANISM:
Human immunoglobulin E light chain (HB134) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (6)..(6)
<223> OTHER INFORMATION: n is a, c, g, or t <400>
SEQUENCE: 51 tacgtngaat aat 13 <210> SEQ ID NO 52 <211>
LENGTH: 13 <212> TYPE: DNA <213> ORGANISM: Human
immunoglobulin E light chain (H36) <400> SEQUENCE: 52
tacgttgaat aat 13 <210> SEQ ID NO 53 <211> LENGTH: 63
<212> TYPE: DNA <213> ORGANISM: Human immunoglobulin E
light chain (HB134) <400> SEQUENCE: 53 gttggatgtc ctatgaatca
agggtttgag ggaagcgcct gacttctgct ggtaccagtg 60 caa 63 <210>
SEQ ID NO 54 <211> LENGTH: 63 <212> TYPE: DNA
<213> ORGANISM: Human immunoglobulin E light chain (H36)
<400> SEQUENCE: 54 gttggatgtc ctatgaatca agggtttggg
ggaagcgcct gacttctgct ggtaccagtg 60 caa 63 <210> SEQ ID NO 55
<211> LENGTH: 63 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Consensus Sequence <400> SEQUENCE: 55 gttggatgtc
ctatgaatca agggtttgrg ggaagcgcct gacttctgct ggtaccagtg 60 caa
63
uspto.report is an independent third-party trademark research tool that is not affiliated, endorsed, or sponsored by the United States Patent and Trademark Office (USPTO) or any other governmental organization. The information provided by uspto.report is based on publicly available data at the time of writing and is intended for informational purposes only.
While we strive to provide accurate and up-to-date information, we do not guarantee the accuracy, completeness, reliability, or suitability of the information displayed on this site. The use of this site is at your own risk. Any reliance you place on such information is therefore strictly at your own risk.
All official trademark data, including owner information, should be verified by visiting the official USPTO website at www.uspto.gov. This site is not intended to replace professional legal advice and should not be used as a substitute for consulting with a legal professional who is knowledgeable about trademark law.