U.S. patent application number 12/489716 was filed with the patent office on 2009-10-15 for imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions.
This patent application is currently assigned to BOEHRINGER INGELHEIM INTERNATIONAL GMBH. Invention is credited to Matthias ECKHARDT, Norbert HAUEL, Frank HIMMELSBACH, Iris KAUFFMANN-HEFNER, Elke LANGKOPF, Michael MARK, Mohammad TADAYYON.
Application Number | 20090258856 12/489716 |
Document ID | / |
Family ID | 34108291 |
Filed Date | 2009-10-15 |
United States Patent
Application |
20090258856 |
Kind Code |
A1 |
ECKHARDT; Matthias ; et
al. |
October 15, 2009 |
IMIDAZOPYRIDAZINONE AND IMIDAZOPYRIDONE DERIVATIVES, THE
PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL
COMPOSITIONS
Abstract
The present invention relates to substituted imidazo-pyridinones
and imidazo-pyridazinones of general formula ##STR00001## wherein Y
and R.sup.1 to R.sup.4 are defined as in claim 1, the tautomers,
enantiomers, diastereomers, the mixtures thereof and the salts
thereof, which have valuable pharmacological properties,
particularly an inhibiting effect on the activity of the enzyme
dipeptidylpeptidase-IV (DPP-IV).
Inventors: |
ECKHARDT; Matthias;
(Biberach, DE) ; HAUEL; Norbert; (Schemmerhofen,
DE) ; LANGKOPF; Elke; (Warthausen, DE) ;
HIMMELSBACH; Frank; (Mittelbiberach, DE) ;
KAUFFMANN-HEFNER; Iris; (Attenweiler, DE) ; TADAYYON;
Mohammad; (Watford, GB) ; MARK; Michael;
(Biberach, DE) |
Correspondence
Address: |
MICHAEL P. MORRIS;BOEHRINGER INGELHEIM USA CORPORATION
900 RIDGEBURY RD, P O BOX 368
RIDGEFIELD
CT
06877-0368
US
|
Assignee: |
BOEHRINGER INGELHEIM INTERNATIONAL
GMBH
Ingelheim
DE
|
Family ID: |
34108291 |
Appl. No.: |
12/489716 |
Filed: |
June 23, 2009 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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10865719 |
Jun 10, 2004 |
7566707 |
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12489716 |
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60487309 |
Jul 15, 2003 |
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Current U.S.
Class: |
514/211.05 ;
514/211.08; 514/211.09; 514/211.1; 514/211.11; 514/221; 514/224.2;
514/226.5; 514/230.5; 514/248; 514/266.21; 514/303; 540/489;
540/521; 540/547; 540/552; 540/573; 540/578; 540/587; 544/105;
544/236; 544/284; 544/49; 544/50; 544/51; 544/63; 544/90;
546/118 |
Current CPC
Class: |
A61P 19/10 20180101;
A61P 37/06 20180101; A61P 7/12 20180101; C07D 487/04 20130101; A61P
3/10 20180101; C07D 471/04 20130101; A61P 19/00 20180101; A61P
19/02 20180101; A61P 3/04 20180101 |
Class at
Publication: |
514/211.05 ;
546/118; 514/303; 544/236; 514/248; 544/284; 514/266.21; 544/63;
514/230.5; 544/90; 544/105; 544/50; 514/224.2; 544/51; 544/49;
514/226.5; 540/521; 540/573; 514/221; 514/211.09; 540/552; 540/489;
540/587; 514/211.11; 514/211.1; 540/578; 540/547; 514/211.08 |
International
Class: |
A61K 31/554 20060101
A61K031/554; C07D 401/14 20060101 C07D401/14; A61K 31/437 20060101
A61K031/437; A61P 3/10 20060101 A61P003/10; A61P 19/02 20060101
A61P019/02; A61P 3/04 20060101 A61P003/04; A61P 19/10 20060101
A61P019/10; A61P 37/06 20060101 A61P037/06; A61K 31/5025 20060101
A61K031/5025; A61K 31/517 20060101 A61K031/517; C07D 413/14
20060101 C07D413/14; A61K 31/536 20060101 A61K031/536; C07D 417/14
20060101 C07D417/14; A61K 31/5415 20060101 A61K031/5415; A61K 31/55
20060101 A61K031/55; A61K 31/551 20060101 A61K031/551; A61K 31/5513
20060101 A61K031/5513; A61K 31/553 20060101 A61K031/553 |
Foreign Application Data
Date |
Code |
Application Number |
Jun 18, 2003 |
DE |
103 27 439.1 |
Claims
1. A compound of formula (I) ##STR00118## wherein R.sup.1 denotes a
C.sub.1-3-alkyl group substituted by a group R.sub.a, where R.sub.a
denotes a 3,4-dihydro-quinolinyl, 3,4-dihydro-isoquinolinyl,
1,4-dihydro-quinazolinyl, 3,4-dihydro-quinazolinyl,
1H-benzo[d][1,2]oxazinyl, 4H-benzo[e][1,3]oxazinyl,
4H-benzo[d][1,3]oxazinyl or 2H-benzo[1,4]oxazinyl group, wherein in
each case in the benzo moiety one to three methyne groups may each
be replaced by a nitrogen atom and in the heterocyclyl moiety a
methylene group may be replaced by a carbonyl group, a
4H-benzo[e][1,3]thiazinyl, 4H-benzo[d][1,3]thiazinyl or
2H-benzo[1,4]thiazinyl group wherein in each case in the benzo
moiety one to three methyne groups may each be replaced by a
nitrogen atom and in the heterocyclyl moiety a methylene group may
be replaced by a carbonyl group and the sulphur atom may be
replaced by a sulphinyl or sulphonyl group, a
2-oxo-2H-benzo[e][1,3]oxazinyl or
2,2-dioxo-1H-benzo[c][1,2]thiazinyl group wherein in each case in
the benzo moiety one to three methyne groups may each be replaced
by a nitrogen atom, a 2,3-dihydro-1H-benzo[e][1,4]diazepinyl,
4,5-dihydro-3H-benzo[b][1,4]diazepinyl or
5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepinyl group wherein in each
case in the benzo moiety one to three methyne groups may each be
replaced by a nitrogen atom and in the heterocyclyl moiety a
methylene group may be replaced by a carbonyl group, a
2,3-dihydro-benzo[f][1,4]oxazepinyl or
2,3-dihydro-benzo[b][1,4]oxazepinyl group wherein in each case in
the benzo moiety one to three methyne groups may each be replaced
by a nitrogen atom and in the heterocyclyl moiety a methylene group
may be replaced by a carbonyl group, a
2,3-dihydro-benzo[b][1,4]thiazepinyl or
2,3-dihydro-benzo[f][1,4]thiazepinyl group wherein in each case in
the benzo moiety one to three methyne groups may each be replaced
by a nitrogen atom and in the heterocyclyl moiety a methylene group
may be replaced by a carbonyl group and the sulphur atom may be
replaced by a sulphinyl or sulphonyl group, a
5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepinyl group wherein in the
benzo moiety one to three methyne groups may each be replaced by a
nitrogen atom, a 11H-dibenzo[b,e]azepinyl or
5H-dibenzo[a,d]cycloheptenyl group wherein in each case in the
benzo moiety one to three methyne groups may each be replaced by a
nitrogen atom and the methylene group in the heterocyclyl moiety
may be replaced by an oxygen or sulphur atom, a carbonyl, sulphinyl
or sulphonyl group or by an imino group substituted by R.sub.x,
where R.sub.x denotes a hydrogen atom or a C.sub.1-4-alkyl,
C.sub.2-4-alkenyl, C.sub.2-4-alkynyl, C.sub.3-6-cycloalkyl,
C.sub.3-6-cycloalkyl-C.sub.1-3-alkyl, aryl, aryl-C.sub.1-3-alkyl,
hydroxy-C.sub.2-4-alkyl, C.sub.1-3-alkyloxy-C.sub.2-4-alkyl,
C.sub.3-6-cycloalkyloxy-C.sub.2-4-alkyl, amino-C.sub.2-4-alkyl,
C.sub.1-3-alkylamino-C.sub.2-4-alkyl,
di-(C.sub.1-3-alkyl)-amino-C.sub.2-4-alkyl,
C.sub.1-3-alkyl-carbonyl, C.sub.1-3-alkyloxy-carbonyl,
C.sub.1-3-alkyloxy-carbonyl-C.sub.1-3-alkyl, aryl-carbonyl,
C.sub.1-3-alkyl-sulphonyl or aryl-sulphonyl group, a
phenanthridinyl group wherein in the benzo moiety one to three
methyne groups may each be replaced by a nitrogen atom, and a
1,2,3,4-tetrahydro-phenanthridinyl,
1,2,3,4,4a,10b-hexahydro-phenanthridinyl,
2,3-dihydro-1H-4-aza-cyclopenta[a]naphthyl or a
8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphthyl group wherein
in each case in the benzo moiety one to three methyne groups may
each be replaced by a nitrogen atom and one or two methylene groups
may each be replaced by an oxygen atom or a carbonyl group, while,
if two methylene groups are each replaced by an oxygen atom, the
oxygen atoms must be separated from one another by at least two
methylene units, a phenanthrenyl group wherein in each case one to
three of the methyne groups in position 1 to 4 and 5 to 8 may each
be replaced by a nitrogen atom, a 1,2,3,4-tetrahydro-phenanthrenyl
or a 1,2,3,4,5,6,7,8-octahydro-phenanthrenyl group wherein in each
case one or two of the methylene groups in position 1 to 4 and 5 to
8 may each be replaced by an oxygen atom or a carbonyl group,
while, if two methylene groups are each replaced by an oxygen atom,
the oxygen atoms must be separated from one another by at least two
methylene units, a 5H-benzo[e]pyrrolo[1,2-a][1,4]diazepinyl,
thieno[3,2-b][1,4]benzoxazepinyl, 5H-dibenzo[d,f][1,3]diazepinyl or
a 5-oxa-7-aza-dibenzo[a,c]cycloheptenyl group wherein in each case
in the benzo moiety one to three methyne groups may each be
replaced by a nitrogen atom, a naphtho[1,2-d]oxazolyl,
naphtho[2,1-d]oxazolyl, naphtho[1,2-d]thiazolyl,
naphtho[2,1-d]thiazolyl, naphtho[1,2-d]imidazolyl,
naphtho[1,2-b]furanyl or naphtho[2,1-b]furanyl group wherein in
each case in the naphthyl moiety one to three methyne groups may
each be replaced by a nitrogen atom, or a furo[3,2-c]isoquinolinyl,
pyrazolo[1,5-c]quinazolinyl or 1H-perimidinyl group, while the
methylene and methyne groups of the above mentioned radicals
R.sub.a may be substituted by the groups R.sup.10 to R.sup.13 and
additionally by a C.sub.1-3-alkyl group and the imino groups of the
above mentioned radicals R.sub.a may be substituted by the groups
R.sub.X, as hereinbefore defined and R.sup.10 denotes a hydrogen
atom, a fluorine, chlorine, bromine or iodine atom, a
C.sub.1-4-alkyl, hydroxy, or C.sub.1-4-alkyloxy group, a nitro,
amino, C.sub.1-3-alkylamino, di-(C.sub.1-3-alkyl)amino,
cyano-C.sub.1-3-alkylamino,
N-(cyano-C.sub.1-3-alkyl)-N--(C.sub.1-3-alkyl)-amino,
C.sub.1-3-alkyloxy-carbonyl-C.sub.1-3-alkylamino, pyrrolidin-1-yl,
piperidin-1-yl, morpholin-4-yl, piperazin-1-yl, or
4-(C.sub.1-3-alkyl)-piperazin-1-yl group, a
C.sub.1-3-alkyl-carbonylamino, arylcarbonylamino,
aryl-C.sub.1-3-alkyl-carbonylamino,
C.sub.1-3-alkyloxy-carbonylamino, aminocarbonylamino,
C.sub.1-3-alkylaminocarbonylamino,
di-(C.sub.1-3-alkyl)aminocarbonylamino,
pyrrolidin-1-yl-carbonylamino, piperidin-1-yl-carbonylamino,
morpholin-4-yl-carbonylamino, piperazin-1-yl-carbonylamino or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-carbonylamino,
C.sub.1-3-alkyl-sulphonylamino,
bis-(C.sub.1-3-alkylsulphonyl)-amino, aminosulphonylamino,
C.sub.1-3-alkylamino-sulphonylamino,
di-(C.sub.1-3-alkyl)amino-sulphonylamino,
pyrrolidin-1-yl-sulphonylamino, piperidin-1-yl-sulphonylamino,
morpholin-4-yl-sulphonylamino, piperazin-1-yl-sulphonylamino or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-sulphonylamino,
(C.sub.1-3-alkylamino)thiocarbonylamino,
(C.sub.1-3-alkyloxy-carbonyl-amino)carbonylamino,
arylsulphonylamino or aryl-C.sub.1-3-alkyl-sulphonyl-amino group,
an N--(C.sub.1-3-alkyl)-C.sub.1-3-alkyl-carbonylamino,
N--(C.sub.1-3-alkyl)-arylcarbonylamino,
N--(C.sub.1-3-alkyl)-aryl-C.sub.1-3-alkyl-carbonylamino,
N--(C.sub.1-3-alkyl)-C.sub.1-3-alkyloxy-carbonylamino,
N-(aminocarbonyl)-C.sub.1-3-alkylamino,
N--(C.sub.1-3-alkyl-aminocarbonyl)-C.sub.1-3-alkylamino,
N-[di-(C.sub.1-3-alkyl)aminocarbonyl]-C.sub.1-3-alkylamino,
N--(C.sub.1-3-alkyl)-C.sub.1-3-alkyl-sulphonylamino,
N--(C.sub.1-3-alkyl)-arylsulphonylamino, or
N--(C.sub.1-3-alkyl)-aryl-C.sub.1-3-alkyl-sulphonylamino group, a
2-oxo-imidazolidin-1-yl, 2,4-dioxo-imidazolidin-1-yl,
2,5-dioxo-imidazolidin-1-yl or 2-oxo-hexahydropyrimidin-1-yl group
wherein the nitrogen atom in the 3 position may be substituted in
each case by a methyl or ethyl group, a cyano, carboxy,
C.sub.1-3-alkyloxy-carbonyl, aminocarbonyl,
C.sub.1-3-alkyl-aminocarbonyl, di-(C.sub.1-3-alkyl)-aminocarbonyl,
pyrrolidin-1-yl-carbonyl, piperidin-1-yl-carbonyl,
morpholin-4-yl-carbonyl, piperazin-1-yl-carbonyl or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-carbonyl group, a
C.sub.1-3-alkyl-carbonyl or an arylcarbonyl group, a
carboxy-C.sub.1-3-alkyl,
C.sub.1-3-alkyloxy-carbonyl-C.sub.1-3-alkyl, cyano-C.sub.1-3-alkyl,
aminocarbonyl-C.sub.1-3-alkyl,
C.sub.1-3-alkyl-aminocarbonyl-C.sub.1-3-alkyl,
di-(C.sub.1-3-alkyl)-aminocarbonyl-C.sub.1-3-alkyl,
pyrrolidin-1-yl-carbonyl-C.sub.1-3-alkyl,
piperidin-1-yl-carbonyl-C.sub.1-3-alkyl,
morpholin-4-yl-carbonyl-C.sub.1-3-alkyl,
piperazin-1-yl-carbonyl-C.sub.1-3-alkyl or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-carbonyl-C.sub.1-3-alkyl group,
a carboxy-C.sub.1-3-alkyloxy,
C.sub.1-3-alkyloxy-carbonyl-C.sub.1-3-alkyloxy,
cyano-C.sub.1-3-alkyloxy, aminocarbonyl-C.sub.1-3-alkyloxy,
C.sub.1-3-alkyl-aminocarbonyl-C.sub.1-3-alkyloxy,
di-(C.sub.1-3-alkyl)-aminocarbonyl-C.sub.1-3-alkyloxy,
pyrrolidin-1-yl-carbonyl-C.sub.1-3-alkyloxy,
piperidin-1-yl-carbonyl-C.sub.1-3-alkyloxy,
morpholin-4-yl-carbonyl-C.sub.1-3-alkyloxy,
piperazin-1-yl-carbonyl-C.sub.1-3-alkyloxy or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-carbonyl-C.sub.1-3-alkyloxy
group, a hydroxy-C.sub.1-3-alkyl,
C.sub.1-3-alkyloxy-C.sub.1-3-alkyl, amino-C.sub.1-3-alkyl,
C.sub.1-3-alkylamino-C.sub.1-3-alkyl,
di-(C.sub.1-3-alkyl)-amino-C.sub.1-3-alkyl,
pyrrolidin-1-yl-C.sub.1-3-alkyl, piperidin-1-yl-C.sub.1-3-alkyl,
morpholin-4-yl-C.sub.1-3-alkyl, piperazin-1-yl-C.sub.1-3-alkyl or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-C.sub.1-3-alkyl group, a
hydroxy-C.sub.1-3-alkyloxy, C.sub.1-3-alkyloxy-C.sub.1-3-alkyloxy,
C.sub.1-3-alkylsulphanyl-C.sub.1-3-alkyloxy,
C.sub.1-3-alkylsulphinyl-C.sub.1-3-alkyloxy,
C.sub.1-3-alkylsulphonyl-C.sub.1-3-alkyloxy,
amino-C.sub.1-3-alkyloxy, C.sub.1-3-alkylamino-C.sub.1-3-alkyloxy,
di-(C.sub.1-3-alkyl)-amino-C.sub.1-3-alkyloxy,
pyrrolidin-1-yl-C.sub.1-3-alkyloxy,
piperidin-1-yl-C.sub.1-3-alkyloxy,
morpholin-4-yl-C.sub.1-3-alkyloxy,
piperazin-1-yl-C.sub.1-3-alkyloxy or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-C.sub.1-3-alkyloxy group, a
mercapto, C.sub.1-3-alkylsulphanyl, C.sub.1-3-alkysulphinyl,
C.sub.1-3-alkylsulphonyl, C.sub.1-3-alkylsulphonyloxy,
arylsulphonyloxy, trifluoromethylsulphanyl,
trifluoromethylsulphinyl or trifluoromethylsulphonyl group, a
sulpho, aminosulphonyl, C.sub.1-3-alkyl-aminosulphonyl,
di-(C.sub.1-3-alkyl)-aminosulphonyl, pyrrolidin-1-yl-sulphonyl,
piperidin-1-yl-sulphonyl, morpholin-4-yl-sulphonyl,
piperazin-1-yl-sulphonyl or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-sulphonyl group, a methyl or
methoxy group substituted by 1 to 3 fluorine atoms, an ethyl or
ethoxy group substituted by 1 to 5 fluorine atoms, a
C.sub.2-4-alkenyl or C.sub.2-4-alkynyl group, a
C.sub.3-4-alkenyloxy or C.sub.3-4-alkynyloxy group, a
C.sub.3-6-cycloalkyl or C.sub.3-6-cycloalkyloxy group, a
C.sub.3-6-cycloalkyl-C.sub.1-3-alkyl or
C.sub.3-6-cycloalkyl-C.sub.1-3-alkyloxy group or an aryl, aryloxy,
aryl-C.sub.1-3-alkyl or aryl-C.sub.1-3-alkyloxy group, R.sup.11 and
R.sup.12, which may be identical or different, in each case
represent a hydrogen atom, a fluorine, chlorine, bromine or iodine
atom, a C.sub.1-3-alkyl, trifluoromethyl, hydroxy,
C.sub.1-3-alkyloxy or cyano group, or R.sup.11 together with
R.sup.12, if these are bound to adjacent carbon atoms, also denotes
a methylenedioxy, difluoromethylenedioxy, ethylenedioxy or a
straight-chain C.sub.3-5-alkylene group and R.sup.13 denotes a
hydrogen atom, a fluorine, chlorine or bromine atom, a
trifluoromethyl, C.sub.1-3-alkyl or C.sub.1-3-alkyloxy group,
R.sup.2 denotes a hydrogen, fluorine or chlorine atom, a
C.sub.1-6-alkyl group, a C.sub.2-4-alkenyl group, a
C.sub.3-4-alkynyl group, a C.sub.3-6-cycloalkyl group, a
C.sub.3-6-cycloalkyl-C.sub.1-3-alkyl group, a tetrahydrofuran-3-yl,
tetrahydropyran-3-yl, tetrahydropyran-4-yl, tetrahydrofuranylmethyl
or tetrahydropyranylmethyl group, an aryl group, an
aryl-C.sub.1-4-alkyl group, an aryl-C.sub.2-3-alkenyl group, an
arylcarbonyl group, an arylcarbonyl-C.sub.1-2-alkyl group, a
heteroaryl group, a heteroaryl-C.sub.1-3-alkyl group, a
furanylcarbonyl, thienylcarbonyl, thiazolylcarbonyl or
pyridylcarbonyl group, a furanylcarbonylmethyl,
thienylcarbonylmethyl, thiazolylcarbonylmethyl or
pyridylcarbonylmethyl group, a C.sub.1-4-alkyl-carbonyl group, a
C.sub.1-4-alkyl-carbonyl-C.sub.1-2-alkyl group, a
C.sub.3-6-cycloalkyl-carbonyl group, a
C.sub.3-6-cycloalkyl-carbonyl-C.sub.1-2-alkyl group, an aryl-A or
aryl-A-C.sub.1-3-alkyl group, where A denotes an oxygen or sulphur
atom, an imino, C.sub.1-3-alkylimino, sulphinyl or sulphonyl group,
a group R.sub.b, where R.sub.b denotes a cyano, carboxy,
C.sub.1-3-alkyloxy-carbonyl, aminocarbonyl,
C.sub.1-3-alkyl-amino-carbonyl,
di-(C.sub.1-3-alkyl)-amino-carbonyl, pyrrolidin-1-ylcarbonyl,
piperidin-1-ylcarbonyl, morpholin-4-ylcarbonyl,
piperazin-1-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl,
4-ethylpiperazin-1-ylcarbonyl, hydroxy, mercapto,
C.sub.1-3-alkyloxy, C.sub.1-3-alkylsulphenyl,
C.sub.1-3-alkylsulphinyl, C.sub.1-3-alkylsulphonyl, amino,
C.sub.1-3-alkylamino, di-(C.sub.1-3-alkyl)-amino, pyrrolidin-1-yl,
piperidin-1-yl, morpholin-4-yl, piperazin-1-yl,
4-methyl-piperazin-1-yl or 4-ethyl-piperazin-1-yl group, or a
C.sub.1-4-alkyl group substituted by a group R.sub.b, where R.sub.b
is as hereinbefore defined, Y denotes a group of formula
C--R.sup.5, while R.sup.5 is defined like R.sup.2 and in each case
one of the two groups R.sup.2 and R.sup.5 must be a hydrogen atom
or a C.sub.1-3-alkyl group, R.sup.3 denotes a C.sub.3-8-alkyl
group, a C.sub.1-3-alkyl group substituted by a group R.sub.c,
where R.sub.c, denotes a C.sub.3-7-cycloalkyl group optionally
substituted by one or two C.sub.1-3-alkyl groups, a
C.sub.5-7-cycloalkenyl group optionally substituted by one or two
C.sub.1-3-alkyl groups, an aryl group or a furanyl, thienyl,
oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl,
pyridazinyl, pyrimidyl or pyrazinyl group, while the above
mentioned heterocyclic groups may each be substituted by one or two
C.sub.1-3-alkyl groups or by a fluorine, chlorine, bromine or
iodine atom or by a trifluoromethyl, cyano or C.sub.1-3-alkyloxy
group, a C.sub.3-8-alkenyl group, a C.sub.3-6-alkenyl group
substituted by a fluorine, chlorine or bromine atom or by a
trifluoromethyl group, a C.sub.3-8-alkynyl group, an aryl group or
an aryl-C.sub.2-4-alkenyl group, and R.sup.4 denotes an
azetidin-1-yl or pyrrolidin-1-yl group which is substituted in the
3 position by an amino, C.sub.1-3-alkylamino or a
di-(C.sub.1-3-alkyl)amino group and may additionally be substituted
by one or two C.sub.1-3-alkyl groups, a piperidin-1-yl or
hexahydroazepin-1-yl group which is substituted in the 3 position
or in the 4 position by an amino, C.sub.1-3-alkylamino or a
di-(C.sub.1-3-alkyl)amino group and may additionally be substituted
by one or two C.sub.1-3-alkyl groups, a 3-amino-piperidin-1-yl
group wherein the piperidin-1-yl-moiety is additionally substituted
by an aminocarbonyl, C.sub.1-2-alkyl-aminocarbonyl,
di-(C.sub.1-2-alkyl)aminocarbonyl, pyrrolidin-1-yl-carbonyl,
(2-cyano-pyrrolidin-1-yl-)carbonyl, thiazolidin-3-yl-carbonyl,
(4-cyano-thiazolidin-3-yl)carbonyl, piperidin-1-ylcarbonyl or
morpholin-4-ylcarbonyl group, a 3-amino-piperidin-1-yl group
wherein the piperidin-1-yl moiety in the 4 position or in the
position is additionally substituted by a hydroxy or methoxy group,
a 3-amino-piperidin-1-yl group wherein the methylene group in the 2
position or in the 6 position is replaced by a carbonyl group, a
piperidin-1-yl or hexahydroazepin-1-yl group substituted in the 3
position by an amino, C
.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)-amino-group, wherein in
each case two hydrogen atoms on the carbon skeleton of the
piperidin-1-yl or hexahydroazepin-1-yl-group are replaced by a
straight-chain alkylene bridge, this bridge containing 2 to 5
carbon atoms if the two hydrogen atoms are located on the same
carbon atom, or 1 to 4 carbon atoms, if the hydrogen atoms are
located on adjacent carbon atoms, or 1 to 4 carbon atoms, if the
hydrogen atoms are located on carbon atoms which are separated by
one atom, or 1 to 3 carbon atoms if the two hydrogen atoms are
located on carbon atoms separated by two atoms, an azetidin-1-yl,
pyrrolidin-1-yl, piperidin-1-yl or hexahydroazepin-1-yl group which
is substituted by an amino-C.sub.1-3-alkyl,
C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)-amino-C.sub.1-3-alkyl group, a piperazin-1-yl
or [1,4]diazepan-1-yl group optionally substituted at the carbon
skeleton by one or two C.sub.1-3-alkyl groups, a
3-imino-piperazin-1-yl, 3-imino-[1,4]diazepan-1-yl or
5-imino-[1,4]diazepan-1-yl group optionally substituted at the
carbon skeleton by one or two C.sub.1-3-alkyl groups, a
[1,4]diazepan-1-yl group optionally substituted by one or two
C.sub.1-3-alkyl groups, which is substituted in the 6 position by
an amino group, a C.sub.3-7-cycloalkyl group which is substituted
by an amino, C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)-amino
group, a C.sub.3-7-cycloalkyl group which is substituted by an
amino-C.sub.1-3-alkyl, C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, a
C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl group wherein the cycloalkyl
moiety is substituted by an amino, C.sub.1-3-alkylamino or
di-(C.sub.1-3-alkyl)-amino group, a
C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl group wherein the cycloalkyl
moiety is substituted by an amino-C.sub.1-3-alkyl,
C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, a
C.sub.3-7-cycloalkylamino group wherein the cycloalkyl moiety is
substituted by an amino, C.sub.1-3-alkylamino or
di-(C.sub.1-3-alkyl)-amino group, while the two nitrogen atoms at
the cycloalkyl moiety are separated from one another by at least
two carbon atoms, an
N--(C.sub.3-7-cycloalkyl)-N--(C.sub.1-3-alkyl)-amino group wherein
the cycloalkyl moiety is substituted by an amino,
C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)-amino group, while the
two nitrogen atoms at the cycloalkyl moiety are separated from one
another by at least two carbon atoms, a C.sub.3-7-cycloalkylamino
group wherein the cycloalkyl moiety is substituted by an
amino-C.sub.1-3-alkyl, C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, an
N--(C.sub.3-7-cycloalkyl)-N--(C.sub.1-3-alkyl)-amino group wherein
the cycloalkyl moiety is substituted by an amino-C.sub.1-3-alkyl,
C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, a
C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl-amino group wherein the
cycloalkyl moiety is substituted by an amino, C.sub.1-3-alkylamino
or di-(C.sub.1-3-alkyl)-amino group, an
N--(C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl)-N--(C.sub.1-2-alkyl)-amino
group wherein the cycloalkyl moiety is substituted by an amino,
C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)-amino group, a
C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl-amino group wherein the
cycloalkyl moiety is substituted by an amino-C.sub.1-3-alkyl,
C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, an
N--(C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl)-N--(C.sub.1-2-alkyl)-amino
group wherein the cycloalkyl moiety is substituted by an
amino-C.sub.1-3-alkyl, C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, a
R.sup.19--C.sub.2-4-alkylamino group wherein R.sup.19 is separated
from the nitrogen atom of the C.sub.2-4-alkylamino moiety by at
least two carbon atoms and R.sup.19 denotes an amino,
C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)-amino group, an
R.sup.19--C.sub.2-4-alkylamino group wherein the nitrogen atom of
the C.sub.2-4-alkylamino moiety is substituted by a C.sub.1-3-alkyl
group and R.sup.19 is separated from the nitrogen atom of the
C.sub.2-4-alkylamino moiety by at least two carbon atoms, while
R.sup.19 is as hereinbefore defined, an amino group substituted by
the group R.sup.20 wherein R.sup.20 denotes an azetidin-3-yl,
azetidin-2-ylmethyl, azetidin-3-ylmethyl, pyrrolidin-3-yl,
pyrrolidin-2-ylmethyl, pyrrolidin-3-ylmethyl, piperidin-3-yl,
piperidin-4-yl, piperidin-2-ylmethyl, piperidin-3-ylmethyl or
piperidin-4-ylmethyl group, while the groups mentioned for R.sup.20
may each be substituted by one or two C.sub.1-3-alkyl groups, an
amino group substituted by the group R.sup.20 and a C.sub.1-3-alkyl
group wherein R.sup.20 is as hereinbefore defined, while the groups
mentioned for R.sup.20 may each be substituted by one or two
C.sub.1-3-alkyl groups, an R.sup.19--C.sub.3-4-alkyl group wherein
the C.sub.3-4-alkyl moiety is straight-chained and may additionally
be substituted by one or two C.sub.1-3-alkyl groups, while R.sup.19
is as hereinbefore defined, a 3-amino-2-oxo-piperidin-5-yl or
3-amino-2-oxo-1-methyl-piperidin-5-yl group, a pyrrolidin-3-yl,
piperidin-3-yl, piperidin-4-yl, hexahydroazepin-3-yl or
hexahydroazepin-4-yl group which is substituted in the 1 position
by an amino, C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)amino
group, or an azetidin-2-yl-C.sub.1-2-alkyl,
azetidin-3-yl-C.sub.1-2-alkyl, pyrrolidin-2-yl-C.sub.1-2-alkyl,
pyrrolidin-3-yl, pyrrolidin-3-yl-C.sub.1-2-alkyl,
piperidin-2-yl-C.sub.1-2-alkyl, piperidin-3-yl,
piperidin-3-yl-C.sub.1-2-alkyl, piperidin-4-yl or
piperidin-4-yl-C.sub.1-2-alkyl group, while the above mentioned
groups may each be substituted by one or two C.sub.1-3-alkyl
groups, while by the aryl groups mentioned in the definition of the
above groups are meant phenyl or naphthyl groups which may be mono-
or disubstituted by R.sub.h, while the substituents may be
identical or different and R.sub.h denotes a fluorine, chlorine,
bromine or iodine atom, a trifluoromethyl, cyano, nitro, amino,
aminocarbonyl, aminosulphonyl, methylsulphonyl, acetylamino,
methylsulphonylamino, C.sub.1-3-alkyl, cyclopropyl, ethenyl,
ethynyl, hydroxy, C.sub.1-3-alkyloxy, difluoromethoxy or
trifluoromethoxy group, by the heteroaryl groups mentioned in the
definition of the above groups are meant a pyrrolyl, furanyl,
thienyl, pyridyl, indolyl, benzofuranyl, benzothiophenyl,
quinolinyl or isoquinolinyl group, or a pyrrolyl, furanyl, thienyl
or pyridyl group, wherein one or two methyne groups are replaced by
nitrogen atoms, or an indolyl, benzofuranyl, benzothiophenyl,
quinolinyl or isoquinolinyl group, wherein one to three methyne
groups are replaced by nitrogen atoms, and the above mentioned
heteroaryl groups may be mono- or disubstituted by R.sub.h, while
the substituents may be identical or different and R.sub.h is as
hereinbefore defined, while, unless otherwise stated, the above
mentioned alkyl, alkenyl and alkynyl groups may be straight-chain
or branched, and the hydrogen atoms of the methyl or ethyl groups
contained in the definitions may be wholly or partly replaced by
fluorine atoms, or a tautomer, enantiomer, diastereomer, mixture
thereof, prodrug thereof or salt thereof.
2. The compound of formula I according to claim 1, wherein R.sup.1
denotes a methyl group substituted by a group R.sub.a, where
R.sub.a denotes a 3,4-dihydro-quinolinyl group, a
3,4-dihydro-isoquinolinyl group, a 1,4-dihydro-quinazolinyl or
4-oxo-1,4-dihydro-quinazolinyl group, a 3,4-dihydro-quinazolinyl or
4-oxo-3,4-dihydro-quinazolinyl group, a 1H-benzo[d][1,2]oxazinyl or
1-oxo-1H-benzo[d][1,2]oxazinyl group, a 4H-benzo[e][1,3]oxazinyl or
4-oxo-4H-benzo[e][1,3]oxazinyl group, a 4H-benzo[d][1,3]oxazinyl or
4-oxo-4H-benzo[d][1,3]oxazinyl group, a 2H-benzo[1,4]oxazinyl or
2-oxo-2H-benzo[1,4]oxazinyl group, a 4H-benzo[e][1,3]thiazinyl or
4-oxo-4H-benzo[e][1,3]thiazinyl group, a 4H-benzo[d][1,3]thiazinyl
or 2H-benzo[1,4]thiazinyl group, a 2-oxo-2H-benzo[e][1,3]oxazinyl
or 2,2-dioxo-1H-benzo[c][1,2]thiazinyl group, a
2,3-dihydro-1H-benzo[e][1,4]diazepinyl or
2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepinyl group, a
4,5-dihydro-3H-benzo[b][1,4]diazepinyl or
4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepinyl group, a
5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepinyl group, a
2,3-dihydro-benzo[f][1,4]oxazepinyl or
2,3-dihydro-benzo[b][1,4]oxazepinyl group, a
2,3-dihydro-benzo[f][1,4]thiazepinyl or
2,3-dihydro-benzo[b][1,4]thiazepinyl group, a
5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepinyl group, a
11H-dibenzo[b,e]azepinyl or 11-oxo-11H-dibenzo[b,e]azepinyl group,
a 11H-benzo[e]pyrido[3,2-b]azepinyl or a
5H-1,9,10-triaza-dibenzo[a,d]-cycloheptenyl group, a
5H-dibenzo[b,e][1,4]diazepinyl or dibenzo[b,f][1,4]oxazepinyl
group, a dibenzo[b,f][1,4]thiazepinyl,
5-oxo-dibenzo[b,f][1,4]thiazepinyl or
5,5-dioxo-dibenzo[b,f][1,4]thiazepinyl group, a
5H-dibenzo[a,d]cycloheptenyl or 5H-dibenzo[b,f]azepinyl group, a
phenanthridinyl, benzo[c][1,5]naphthyridinyl,
benzo[h][1,6]naphthyridinyl, benzo[c][1,8]naphthyridinyl,
benzo[f][1,7]naphthyridinyl or 1,5,9-triaza-phenanthrenyl group, a
1,2,3,4-tetrahydro-phenanthridinyl,
1,2,3,4,4a,10b-hexahydro-phenanthridinyl,
2,3-dihydro-1H-4-aza-cyclopenta[a]naphthyl or
8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphthyl group, a
2,3-dihydro-1H-4-oxa-10-aza-phenanthrenyl or
1-oxo-2,3-dihydro-1H-4-oxa-10-aza-phenanthrenyl group, a
phenanthrenyl, benzo[h]quinolinyl, benzo[f]quinolinyl or
benzo[f]quinoxalinyl group, a
5H-benzo[e]pyrrolo[1,2-a][1,4]diazepinyl,
thieno[3,2-b][1,4]benzoxazepinyl, 5H-dibenzo[d,f][1,3]diazepinyl or
5-oxa-7-aza-dibenzo[a,c]cycloheptenyl group, a
naphtho[1,2-d]oxazolyl, naphtho[2,1-d]oxazolyl,
naphtho[1,2-d]thiazolyl, naphtho[2,1-d]thiazolyl,
naphtho[1,2-d]imidazolyl, naphtho[1,2-b]furanyl or
naphtho[2,1-b]furanyl group, or a furo[3,2-c]isoquinolinyl,
pyrazolo[1,5-c]quinazolinyl or 1H-perimidinyl group, while the
benzo groups of the above mentioned radicals R.sub.a are
substituted by the groups R.sup.10 to R.sup.13 and the alkylene
units of the above mentioned groups R.sub.a may be substituted by
one or two fluorine atoms or one or two C.sub.1-3-alkyl or
C.sub.1-3-alkyloxy-carbonyl groups and the imino groups of the
above mentioned radicals R.sub.a may be substituted by a
C.sub.1-3-alkyl group and R.sup.10 denotes a hydrogen atom, a
fluorine, chlorine, bromine or iodine atom, a C.sub.1-3-alkyl or
cyclopropyl group, a hydroxy, C.sub.1-3-alkyloxy or cyclopropyloxy
group, a nitro, amino, C.sub.1-3-alkylamino or
di-(C.sub.1-3-alkyl)amino group, a C.sub.1-3-alkyl-carbonylamino or
C.sub.1-3-alkyl-sulphonylamino group, a cyano, carboxy,
C.sub.1-3-alkyloxy-carbonyl, aminocarbonyl,
C.sub.1-3-alkyl-aminocarbonyl or di-(C.sub.1-3-alkyl)-aminocarbonyl
group, a mercapto, C.sub.1-3-alkylsulphanyl,
C.sub.1-3-alkysulphinyl, C.sub.1-3-alkylsulphonyl or aminosulphonyl
group or a difluoromethyl, trifluoromethyl, difluoromethoxy or
trifluoromethoxy group and R.sup.11, R.sup.12 and R.sup.13, which
may be identical or different, in each case represent a hydrogen
atom, a fluorine, chlorine or bromine atom, a methyl,
trifluoromethyl or methoxy group, R.sup.2 denotes a hydrogen atom
or a C.sub.1-3-alkyl, cyclopropyl, trifluoromethyl, cyanomethyl or
2-cyano-ethyl group, Y denotes a group of formula C--R.sup.5, while
R.sup.5 denotes a hydrogen atom or a C.sub.1-3-alkyl group, R.sup.3
denotes a 2-buten-1-yl or 3-methyl-2-buten-1-yl group, a
1-buten-1-yl group, a 2-butyn-1-yl group or a
1-cyclopenten-1-ylmethyl group and R.sup.4 denotes a
(3-amino-piperidin-1-yl) group, while, unless otherwise stated, the
above mentioned alkyl groups may be straight-chain or branched, or
a tautomer, enantiomer, diastereomer, mixture thereof, or salt
thereof.
3. The compound of formula I according to claim 2, wherein R.sup.1
denotes a methyl group substituted by a group R.sub.a, where
R.sub.a denotes a 3,4-dihydro-quinolin-2-yl group, a
3,4-dihydro-isoquinolin-1-yl group, a 1,4-dihydro-quinazolin-2-yl
or 4-oxo-1,4-dihydro-quinazolin-2-yl group, a
3,4-dihydro-quinazolin-2-yl or 4-oxo-3,4-dihydro-quinazolin-2-yl
group, a 1H-benzo[d][1,2]oxazin-4-yl or
1-oxo-1H-benzo[d][1,2]oxazin-4-yl group, a
4H-benzo[e][1,3]oxazin-2-yl or 4-oxo-4H-benzo[e][1,3]oxazin-2-yl
group, a 4H-benzo[d][1,3]oxazin-2-yl or
4-oxo-4H-benzo[d][1,3]oxazin-2-yl group, a 2H-benzo[1,4]oxazin-3-yl
or 2-oxo-2H-benzo[1,4]oxazin-3-yl group, a
4H-benzo[e][1,3]thiazin-2-yl or 4-oxo-4H-benzo[e][1,3]thiazin-2-yl
group, a 4H-benzo[d][1,3]thiazin-2-yl or 2H-benzo[1,4]thiazin-3-yl
group, a 2-oxo-2H-benzo[e][1,3]oxazin-4-yl or
2,2-dioxo-1H-benzo[c][1,2]thiazin-4-yl group, a
2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl or
2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl group, a
4,5-dihydro-3H-benzo[b]h[1,4]diazepin-2-yl or
4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl group, a
5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-yl group, a
2,3-dihydro-benzo[f][1,4]oxazepin-5-yl or
2,3-dihydro-benzo[b][1,4]oxazepin-4-yl group, a
2,3-dihydro-benzo[f][1,4]thiazepin-5-yl or
2,3-dihydro-benzo[b][1,4]thiazepin-4-yl group, a
5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepin-2-yl group, a
11H-dibenzo[b,e]azepin-6-yl or 11-oxo-11H-dibenzo[b,e]azepin-6-yl
group, a 11H-benzo[e]pyrido[3,2-b]azepin-6-yl or a
5H-1,9,10-triaza-dibenzo[a,d]-cyclohepten-11-yl group, a
5H-dibenzo[b,e][1,4]diazepin-11-yl or
dibenzo[b,f][1,4]oxazepin-11-yl group, a
dibenzo[b,f][1,4]thiazepin-11-yl,
5-oxo-dibenzo[b,f][1,4]thiazepin-11-yl or
5,5-dioxo-dibenzo[b,f][1,4]thiazepin-11-yl group, a
5H-dibenzo[a,d]cyclohepten-10-yl or 5H-dibenzo[b,f]azepin-10-yl
group, a phenanthridin-6-yl, benzo[c][1,5]naphthyridin-6-yl,
benzo[h][1,6]naphthyridin-5-yl, benzo[c][1,8]naphthyridin-6-yl,
benzo[f][1,7]naphthyridin-5-yl or 1,5,9-triaza-phenanthren-10-yl
group, a 1,2,3,4-tetrahydro-phenanthridin-6-yl,
1,2,3,4,4a,10b-hexahydro-phenanthridin-6-yl,
2,3-dihydro-1H-4-aza-cyclopenta[a]naphth-5-yl or
8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphth-5-yl group, a
2,3-dihydro-1H-4-oxa-10-aza-phenanthren-9-yl or
1-oxo-2,3-dihydro-1H-4-oxa-10-aza-phenanthren-9-yl group, a
phenanthren-9-yl, benzo[h]quinolin-6-yl, benzo[f]quinolin-6-yl or
benzo[f]quinoxalin-6-yl group, a
5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-11-yl,
thieno[3,2-b][1,4]benzoxazepin-9-yl,
5H-dibenzo[d,f][1,3]diazepin-6-yl or
5-oxa-7-aza-dibenzo[a,c]cyclohepten-6-yl group, a
naphtho[1,2-d]oxazol-2-yl, naphtho[2,1-d]oxazol-2-yl,
naphtho[1,2-d]thiazol-2-yl, naphtho[2,1-d]thiazol-2-yl,
naphtho[1,2-d]imidazol-2-yl, naphtho[1,2-b]furan-2-yl or
naphtho[2,1-b]furan-2-yl group, or a furo[3,2-c]isoquinolin-5-yl,
pyrazolo[1,5-c]quinazolin-5-yl or 1H-perimidin-2-yl group, while
the benzo groups of the above mentioned radicals R.sub.a are
substituted by the groups R.sup.10 to R.sup.13 and the alkylene
units of the above mentioned groups R.sub.a may be substituted by
one or two fluorine atoms or one or two methyl groups and the imino
groups of the above mentioned radicals R.sub.a may be substituted
by a methyl group and R.sup.10 denotes a hydrogen atom, a fluorine,
chlorine, bromine or iodine atom, a methyl or ethyl group, a
hydroxy, methoxy or ethoxy group or a difluoromethyl,
trifluoromethyl, difluoromethoxy, or trifluoromethoxy group and
R.sup.11, R.sup.12 and R.sup.13, which may be identical or
different, each denote a hydrogen, fluorine, chlorine or bromine
atom or a methyl, trifluoromethyl or methoxy group, R.sup.2 denotes
a hydrogen atom or a methyl, cyanomethyl, trifluoromethyl, ethyl,
2-cyano-ethyl, propyl, cyclopropyl or isopropyl group, Y denotes a
group of formula C--R.sup.5, while R.sup.5 denotes a hydrogen atom
or a methyl, ethyl, propyl or isopropyl group, R.sup.3 denotes a
2-buten-1-yl or 3-methyl-2-buten-1-yl group, a 1-buten-1-yl group,
a 2-butyn-1-yl group or a 1-cyclopenten-1-ylmethyl group and
R.sup.4 denotes a (3-amino-piperidin-1-yl) group, or a tautomer,
enantiomer, diastereomer, mixture thereof, or salt thereof.
4. (canceled)
5. (canceled)
6. A physiologically acceptable salt of the compound according to
claim 1 with an inorganic or organic acid.
7. A pharmaceutical composition containing a compound according to
claim 1 or a salt with an inorganic or organic acid optionally
together with one or more inert carriers and/or diluents.
8. A process for preparing a composition according to claim 7, said
method comprising incorporating one or more inert carriers and/or
diluents by a non-chemical method.
9. A method of treating a disease selected from the group
consisting of type I and type II diabetes mellitus, arthritis,
obesity, allograft transplantation and osteoporosis caused by
calcitonin comprising the step of administering to a patient in
need thereof a pharmaceutically acceptable amount of a compound
according to claim 1 or a salt with organic or inorganic acid.
10. A process for preparing the compound of formula I according to
claims 1 comprising the steps of deprotecting a compound of general
formula ##STR00119## wherein R.sup.1, R.sup.2, Y and R.sup.3 are as
hereinbefore defined and R.sup.4'' denotes one of the groups
mentioned for R.sup.4 hereinbefore which contain an imino, amino or
alkylamino group, where said imino, amino or alkylamino group is
substituted by a protective group, and subsequently, optionally
cleaving said protective group used during the reactions and/or
optionally resolving said compound into its stereoisomers and/or
converting said compound thus obtained into its physiologically
acceptable salts thereof with an inorganic or organic acid.
Description
RELATED APPLICATIONS
[0001] This application claims benefit of U.S. Serial No. PV
60/487,309, filed Jul. 15, 2003, and claims priority to German
Application No. DE 10327439.1 filed Jun. 18, 2003, each of which is
hereby incorporated by reference in its entirety.
[0002] The present invention relates to new substituted
imidazopyridazinones and imidazopyridones of general formula
##STR00002##
the tautomers, the enantiomers, the diastereomers, the mixtures
thereof, the prodrugs thereof and the salts thereof, particularly
the physiologically acceptable salts thereof with inorganic or
organic acids or bases which have valuable pharmacological
properties, particularly an inhibiting effect on the activity of
the enzyme dipeptidylpeptidase-IV (DPP-IV), the preparation
thereof, the use thereof for the prevention or treatment of
diseases or conditions associated with an increased DPP-IV activity
or capable of being prevented or alleviated by reducing the DPP-IV
activity, particularly type I or type II diabetes mellitus, the
pharmaceutical compositions containing a compound of general
formula (I) or a physiologically acceptable salt thereof as well as
processes for the preparation thereof.
[0003] The present invention thus relates to the above compounds of
general formula I which have valuable pharmacological properties,
the pharmaceutical compositions containing the pharmacologically
effective compounds, the use thereof and processes for the
preparation thereof.
[0004] In the above general formula I
[0005] R.sup.1 denotes a C.sub.1-3-alkyl group substituted by a
group R.sub.a, where [0006] R.sub.a denotes a
3,4-dihydro-quinolinyl, 3,4-dihydro-isoquinolinyl,
1,4-dihydro-quinazolinyl, 3,4-dihydro-quinazolinyl,
1H-benzo[d][1,2]oxazinyl, 4H-benzo[e][1,3]-oxazinyl,
4H-benzo[d][1,3]oxazinyl or 2H-benzo[1,4]oxazinyl group, wherein in
each case [0007] in the benzo moiety one to three methyne groups
may each be replaced by a nitrogen atom and in the heterocyclyl
moiety a methylene group may be replaced by a carbonyl group,
[0008] a 4H-benzo[e][1,3]thiazinyl, 4H-benzo[d][1,3]thiazinyl or
2H-benzo[1,4]thiazinyl group wherein in each case [0009] in the
benzo moiety one to three methyne groups may each be replaced by a
nitrogen atom and in the heterocyclyl moiety a methylene group may
be replaced by a carbonyl group and the sulphur atom may be
replaced by a sulphinyl or sulphonyl group, [0010] a
2-oxo-2H-benzo[e][1,3]oxazinyl or
2,2-dioxo-1H-benzo[c][1,2]thiazinyl group wherein in each case in
the benzo moiety [0011] one to three methyne groups may each be
replaced by a nitrogen atom, [0012] a
2,3-dihydro-1H-benzo[e][1,4]diazepinyl,
4,5-dihydro-3H-benzo[b][1,4]diazepinyl or
5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepinyl group wherein in each
case [0013] in the benzo moiety one to three methyne groups may
each be replaced by a nitrogen atom and in the heterocyclyl moiety
a methylene group may be replaced by a carbonyl group, [0014] a
2,3-dihydro-benzo[f][1,4]oxazepinyl or
2,3-dihydro-benzo[b][1,4]oxazepinyl group wherein in each case
[0015] in the benzo moiety one to three methyne groups may each be
replaced by a nitrogen atom and in the heterocyclyl moiety a
methylene group may be replaced by a carbonyl group, [0016] a
2,3-dihydro-benzo[b][1,4]thiazepinyl or
2,3-dihydro-benzo[f][1,4]thiazepinyl group wherein in each case
[0017] in the benzo moiety one to three methyne groups may each be
replaced by a nitrogen atom and in the heterocyclyl moiety a
methylene group may be replaced by a carbonyl group and the sulphur
atom may be replaced by a sulphinyl or sulphonyl group, [0018] a
5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepinyl group wherein [0019]
in the benzo moiety one to three methyne groups may each be
replaced by a nitrogen atom, [0020] a 11H-dibenzo[b,e]azepinyl or
5H-dibenzo[a,d]cycloheptenyl group wherein in each case [0021] in
the benzo moiety one to three methyne groups may each be replaced
by a nitrogen atom and the methylene group in the heterocyclyl
moiety may be replaced by an oxygen or sulphur atom, a carbonyl,
sulphinyl or sulphonyl group or by an imino group substituted by
R.sub.x, where [0022] R.sub.x denotes a hydrogen atom or a
C.sub.1-4-alkyl, C.sub.2-4-alkenyl, C.sub.2-4-alkynyl,
C.sub.3-6-cycloalkyl, C.sub.3-6-cycloalkyl-C.sub.1-3-alkyl, aryl,
aryl-C.sub.1-3-alkyl, hydroxy-C.sub.2-4-alkyl,
C.sub.1-3-alkyloxy-C.sub.2-4-alkyl,
C.sub.3-6-cycloalkyloxy-C.sub.2-4-alkyl, amino-C.sub.2-4-alkyl,
C.sub.1-3-alkylamino-C.sub.2-4-alkyl,
di-(C.sub.1-3-alkyl)-amino-C.sub.2-4-alkyl,
C.sub.1-3-alkyl-carbonyl, C.sub.1-3-alkyloxy-carbonyl,
C.sub.1-3-alkyloxy-carbonyl-C.sub.1-3-alkyl, aryl-carbonyl,
C.sub.1-3-alkyl-sulphonyl or aryl-sulphonyl group, [0023] a
phenanthridinyl group wherein [0024] in the benzo moiety one to
three methyne groups may each be replaced by a nitrogen atom, and
[0025] a 1,2,3,4-tetrahydro-phenanthridinyl,
1,2,3,4,4a,10b-hexahydro-phenanthridinyl,
2,3-dihydro-1H-4-aza-cyclopenta[a]naphthyl or a
8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphthyl group wherein
in each case [0026] in the benzo moiety one to three methyne groups
may each be replaced by a nitrogen atom and one or two methylene
groups may each be replaced by an oxygen atom or a carbonyl group,
while, if two methylene groups are each replaced by an oxygen atom,
the oxygen atoms must be separated from one another by at least two
methylene units, [0027] a phenanthrenyl group wherein [0028] in
each case one to three of the methyne groups in position 1 to 4 and
5 to 8 may each be replaced by a nitrogen atom, [0029] a
1,2,3,4-tetrahydro-phenanthrenyl or a
1,2,3,4,5,6,7,8-octahydro-phenanthrenyl group wherein [0030] in
each case one or two of the methylene groups in position 1 to 4 and
5 to 8 may each be replaced by an oxygen atom or a carbonyl group,
while, if two methylene groups are each replaced by an oxygen atom,
the oxygen atoms must be separated from one another by at least two
methylene units, [0031] a 5H-benzo[e]pyrrolo[1,2-a][1,4]diazepinyl,
thieno[3,2-b][1,4]benzoxazepinyl, 5H-dibenzo[d,f][1,3]diazepinyl or
a 5-oxa-7-aza-dibenzo[a,c]cycloheptenyl group wherein in each case
[0032] in the benzo moiety one to three methyne groups may each be
replaced by a nitrogen atom, [0033] a naphtho[1,2-d]oxazolyl,
naphtho[2,1-d]oxazolyl, naphtho[1,2-d]thiazolyl,
naphtho[2,1-d]thiazolyl, naphtho[1,2-d]imidazolyl,
naphtho[1,2-b]furanyl or naphtho[2,1-b]furanyl group wherein in
each case [0034] in the naphthyl moiety one to three methyne groups
may each be replaced by a nitrogen atom, [0035] or a
furo[3,2-c]isoquinolinyl, pyrazolo[1,5-c]quinazolinyl or
1H-perimidinyl group, [0036] while the methylene and methyne groups
of the above mentioned radicals R.sub.a may be substituted by the
groups R.sup.10 to R.sup.13 and additionally by a C.sub.1-3-alkyl
group and the imino groups of the above mentioned radicals R.sub.a
may be substituted by the groups R.sub.x as hereinbefore defined
and [0037] R.sup.10 denotes a hydrogen atom, [0038] a fluorine,
chlorine, bromine or iodine atom, [0039] a C.sub.1-4-alkyl,
hydroxy, or C.sub.1-4-alkyloxy group, [0040] a nitro, amino,
C.sub.1-3-alkylamino, di-(C.sub.1-3-alkyl)amino,
cyano-C.sub.1-3-alkylamino,
N-(cyano-C.sub.1-3-alkyl)-N--(C.sub.1-3-alkyl)-amino,
C.sub.1-3-alkyloxy-carbonyl-C.sub.1-3-alkylamino, pyrrolidin-1-yl,
piperidin-1-yl, morpholin-4-yl, piperazin-1-yl, or
4-(C.sub.1-3-alkyl)-piperazin-1-yl group, [0041] a
C.sub.1-3-alkyl-carbonylamino, arylcarbonylamino,
aryl-C.sub.1-3-alkyl-carbonylamino,
C.sub.1-3-alkyloxy-carbonylamino, aminocarbonylamino,
C.sub.1-3-alkylaminocarbonylamino,
di-(C.sub.1-3-alkyl)aminocarbonylamino,
pyrrolidin-1-yl-carbonylamino, piperidin-1-yl-carbonylamino,
morpholin-4-yl-carbonylamino, piperazin-1-yl-carbonylamino or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-carbonylamino,
C.sub.1-3-alkyl-sulphonylamino,
bis-(C.sub.1-3-alkylsulphonyl)-amino, aminosulphonylamino,
C.sub.1-3-alkylamino-sulphonylamino,
di-(C.sub.1-3-alkyl)amino-sulphonylamino,
pyrrolidin-1-yl-sulphonylamino, piperidin-1-yl-sulphonylamino,
morpholin-4-yl-sulphonylamino, piperazin-1-yl-sulphonylamino or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-sulphonylamino,
(C.sub.1-3-alkylamino)thiocarbonylamino,
(C.sub.1-3-alkyloxy-carbonylamino)carbonylamino, arylsulphonylamino
or aryl-C.sub.1-3-alkyl-sulphonylamino group, [0042] an
N--(C.sub.1-3-alkyl)-C.sub.1-3-alkyl-carbonylamino,
N--(C.sub.1-3-alkyl)-arylcarbonylamino,
N--(C.sub.1-3-alkyl)-aryl-C.sub.1-3-alkyl-carbonylamino,
N--(C.sub.1-3-alkyl)-C.sub.1-3-alkyloxy-carbonylamino,
N-(aminocarbonyl)-C.sub.1-3-alkylamino,
N--(C.sub.1-3-alkyl-aminocarbonyl)-C.sub.1-3-alkylamino,
N--[di-(C.sub.1-3-alkyl)aminocarbonyl]-C.sub.1-3-alkylamino,
N--(C.sub.1-3-alkyl)-C.sub.1-3-alkyl-sulphonylamino,
N--(C.sub.1-3-alkyl)-arylsulphonylamino, or
N--(C.sub.1-3-alkyl)-aryl-C.sub.1-3-alkyl-sulphonylamino group,
[0043] a 2-oxo-imidazolidin-1-yl, 2,4-dioxo-imidazolidin-1-yl,
2,5-dioxo-imidazolidin-1-yl or 2-oxo-hexahydropyrimidin-1-yl group
wherein the nitrogen atom in the 3 position may be substituted in
each case by a methyl or ethyl group, [0044] a cyano, carboxy,
C.sub.1-3-alkyloxy-carbonyl, aminocarbonyl,
C.sub.1-3-alkyl-aminocarbonyl, di-(C.sub.1-3-alkyl)-aminocarbonyl,
pyrrolidin-1-yl-carbonyl, piperidin-1-yl-carbonyl,
morpholin-4-yl-carbonyl, piperazin-1-yl-carbonyl or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-carbonyl group, [0045] a
C.sub.1-3-alkyl-carbonyl or an arylcarbonyl group, [0046] a
carboxy-C.sub.1-3-alkyl,
C.sub.1-3-alkyloxy-carbonyl-C.sub.1-3-alkyl, cyano-C.sub.1-3-alkyl,
aminocarbonyl-C.sub.1-3-alkyl,
C.sub.1-3-alkyl-aminocarbonyl-C.sub.1-3-alkyl,
di-(C.sub.1-3-alkyl)-aminocarbonyl-C.sub.1-3-alkyl,
pyrrolidin-1-yl-carbonyl-C.sub.1-3-alkyl,
piperidin-1-yl-carbonyl-C.sub.1-3-alkyl,
morpholin-4-yl-carbonyl-C.sub.1-3-alkyl,
piperazin-1-yl-carbonyl-C.sub.1-3-alkyl or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-carbonyl-C.sub.1-3-alkyl group,
[0047] a carboxy-C.sub.1-3-alkyloxy,
C.sub.1-3-alkyloxy-carbonyl-C.sub.1-3-alkyloxy,
cyano-C.sub.1-3-alkyloxy, aminocarbonyl-C.sub.1-3-alkyloxy,
C.sub.1-3-alkyl-aminocarbonyl-C.sub.1-3-alkyloxy,
di-(C.sub.1-3-alkyl)-aminocarbonyl-C.sub.1-3-alkyloxy,
pyrrolidin-1-yl-carbonyl-C.sub.1-3-alkyloxy,
piperidin-1-yl-carbonyl-C.sub.1-3-alkyloxy,
morpholin-4-yl-carbonyl-C.sub.1-3-alkyloxy,
piperazin-1-yl-carbonyl-C.sub.1-3-alkyloxy or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-carbonyl-C.sub.1-3-alkyloxy
group, [0048] a hydroxy-C.sub.1-3-alkyl,
C.sub.1-3-alkyloxy-C.sub.1-3-alkyl, amino-C.sub.1-3-alkyl,
C.sub.1-3-alkylamino-C.sub.1-3-alkyl,
di-(C.sub.1-3-alkyl)-amino-C.sub.1-3-alkyl,
pyrrolidin-1-yl-C.sub.1-3-alkyl, piperidin-1-yl-C.sub.1-3-alkyl,
morpholin-4-yl-C.sub.1-3-alkyl, piperazin-1-yl-C.sub.1-3-alkyl or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-C.sub.1-3-alkyl group, [0049] a
hydroxy-C.sub.1-3-alkyloxy, C.sub.1-3-alkyloxy-C.sub.1-3-alkyloxy,
C.sub.1-3-alkylsulphanyl-C.sub.1-3-alkyloxy,
C.sub.1-3-alkylsulphinyl-C.sub.1-3-alkyloxy,
C.sub.1-3-alkylsulphonyl-C.sub.1-3-alkyloxy,
amino-C.sub.1-3-alkyloxy, C.sub.1-3-alkylamino-C.sub.1-3-alkyloxy,
di-(C.sub.1-3-alkyl)-amino-C.sub.1-3-alkyloxy,
pyrrolidin-1-yl-C.sub.1-3-alkyloxy,
piperidin-1-yl-C.sub.1-3-alkyloxy,
morpholin-4-yl-C.sub.1-3-alkyloxy,
piperazin-1-yl-C.sub.1-3-alkyloxy or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-C.sub.1-3-alkyloxy group, [0050]
a mercapto, C.sub.1-3-alkylsulphanyl, C.sub.1-3-alkysulphinyl,
C.sub.1-3-alkylsulphonyl, C.sub.1-3-alkylsulphonyloxy,
arylsulphonyloxy, trifluoromethylsulphanyl,
trifluoromethylsulphinyl or trifluoromethylsulphonyl group, [0051]
a sulpho, aminosulphonyl, C.sub.1-3-alkyl-aminosulphonyl,
di-(C.sub.1-3-alkyl)-aminosulphonyl, pyrrolidin-1-yl-sulphonyl,
piperidin-1-yl-sulphonyl, morpholin-4-yl-sulphonyl,
piperazin-1-yl-sulphonyl or
4-(C.sub.1-3-alkyl)-piperazin-1-yl-sulphonyl group, [0052] a methyl
or methoxy group substituted by 1 to 3 fluorine atoms, [0053] an
ethyl or ethoxy group substituted by 1 to 5 fluorine atoms, [0054]
a C.sub.2-4-alkenyl or C.sub.2-4-alkynyl group, [0055] a
C.sub.3-4-alkenyloxy or C.sub.3-4-alkynyloxy group, [0056] a
C.sub.3-6-cycloalkyl or C.sub.3-6-Cycloalkyloxy group, [0057] a
C.sub.3-6-cycloalkyl-C.sub.1-3-alkyl or
C.sub.3-6-cycloalkyl-C.sub.1-3-alkyloxy group or [0058] an aryl,
aryloxy, aryl-C.sub.1-3-alkyl or aryl-C.sub.1-3-alkyloxy group,
[0059] R.sup.11 and R.sup.12, which may be identical or different,
in each case represent a hydrogen atom, a fluorine, chlorine,
bromine or iodine atom, a C.sub.1-3-alkyl, trifluoromethyl,
hydroxy, C.sub.1-3-alkyloxy or cyano group, or [0060] R.sup.11
together with R.sup.12, if these are bound to adjacent carbon
atoms, also denotes a methylenedioxy, difluoromethylenedioxy,
ethylenedioxy or a straight-chain C.sub.3-5-alkylene group and
[0061] R.sup.13 denotes a hydrogen atom, a fluorine, chlorine or
bromine atom, a trifluoromethyl, C.sub.1-3-alkyl or
C.sub.1-3-alkyloxy group, R.sup.2 denotes a hydrogen, fluorine or
chlorine atom, a C.sub.1-6-alkyl group, a C.sub.2-4-alkenyl group,
a C.sub.3-4-alkynyl group, a C.sub.3-6-cycloalkyl group, a
C.sub.3-6-cycloalkyl-C.sub.1-3-alkyl group, a tetrahydrofuran-3-yl,
tetrahydropyran-3-yl, tetrahydropyran-4-yl, tetrahydrofuranylmethyl
or tetrahydropyranylmethyl group, an aryl group, an
aryl-C.sub.1-4-alkyl group, an aryl-C.sub.2-3-alkenyl group, an
arylcarbonyl group, an arylcarbonyl-C.sub.1-2-alkyl group, a
heteroaryl group, a heteroaryl-C.sub.1-3-alkyl group, a
furanylcarbonyl, thienylcarbonyl, thiazolylcarbonyl or
pyridylcarbonyl group, a furanylcarbonylmethyl,
thienylcarbonylmethyl, thiazolylcarbonylmethyl or
pyridylcarbonylmethyl group, a C.sub.1-4-alkyl-carbonyl group, a
C.sub.1-4-alkyl-carbonyl-C.sub.1-2-alkyl group, a
C.sub.3-6-cycloalkyl-carbonyl group, a
C.sub.3-6-cycloalkyl-carbonyl-C.sub.1-2-alkyl group, an aryl-A or
aryl-A-C.sub.1-3-alkyl group, where A denotes an oxygen or sulphur
atom, an imino, C.sub.1-3-alkylimino, sulphinyl or sulphonyl group,
a group R.sub.b, where [0062] R.sub.b denotes a cyano, carboxy,
C.sub.1-3-alkyloxy-carbonyl, aminocarbonyl,
C.sub.1-3-alkylamino-carbonyl, di-(C.sub.1-3-alkyl)-amino-carbonyl,
pyrrolidin-1-ylcarbonyl, piperidin-1-ylcarbonyl,
morpholin-4-ylcarbonyl, piperazin-1-ylcarbonyl,
4-methylpiperazin-1-ylcarbonyl, 4-ethylpiperazin-1-ylcarbonyl,
hydroxy, mercapto, C.sub.1-3-alkyloxy, C.sub.1-3-alkylsulphenyl,
C.sub.1-3-alkylsulphinyl, C.sub.1-3-alkylsulphonyl, amino,
C.sub.1-3-alkylamino, di-(C.sub.1-3-alkyl)-amino, pyrrolidin-1-yl,
piperidin-1-yl, morpholin-4-yl, piperazin-1-yl,
4-methyl-piperazin-1-yl or 4-ethyl-piperazin-1-yl group, or a
C.sub.1-4-alkyl group substituted by a group R.sub.b, where R.sub.b
is as hereinbefore defined, Y denotes a nitrogen atom or a group of
formula C--R.sup.5, [0063] while R.sup.5 is defined like R.sup.2
and in each case one of the two groups R.sup.2 and R.sup.5 must be
a hydrogen atom or a C.sub.1-3-alkyl group, R.sup.3 denotes a
C.sub.3-8-alkyl group, a C.sub.1-3-alkyl group substituted by a
group R.sub.c, where [0064] R.sub.c, denotes a C.sub.3-7-cycloalkyl
group optionally substituted by one or two C.sub.1-3-alkyl groups,
[0065] a C.sub.5-7-cycloalkenyl group optionally substituted by one
or two C.sub.1-3-alkyl groups, [0066] an aryl group or [0067] a
furanyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl,
pyridyl, pyridazinyl, pyrimidyl or pyrazinyl group, while the above
mentioned heterocyclic groups may each be substituted by one or two
C.sub.1-3-alkyl groups or by a fluorine, chlorine, bromine or
iodine atom or by a trifluoromethyl, cyano or C.sub.1-3-alkyloxy
group, a C.sub.3-8-alkenyl group, a C.sub.3-6-alkenyl group
substituted by a fluorine, chlorine or bromine atom or by a
trifluoromethyl group, a C.sub.3-8-alkynyl group, an aryl group or
an aryl-C.sub.2-4-alkenyl group, and R.sup.4 denotes an
azetidin-1-yl or pyrrolidin-1-yl group which is substituted in the
3 position by an amino, C.sub.1-3-alkylamino or a
di-(C.sub.1-3-alkyl)amino group and may additionally be substituted
by one or two C.sub.1-3-alkyl groups, a piperidin-1-yl or
hexahydroazepin-1-yl group which is substituted in the 3 position
or in the 4 position by an amino, C.sub.1-3-alkylamino or a
di-(C.sub.1-3-alkyl)amino group and may additionally be substituted
by one or two C.sub.1-3-alkyl groups, a 3-amino-piperidin-1-yl
group wherein the piperidin-1-yl moiety is additionally substituted
by an aminocarbonyl, C.sub.1-2-alkyl-aminocarbonyl,
di-(C.sub.1-2-alkyl)aminocarbonyl, pyrrolidin-1-yl-carbonyl,
(2-cyano-pyrrolidin-1-yl-)carbonyl, thiazolidin-3-yl-carbonyl,
(4-cyano-thiazolidin-3-yl)carbonyl, piperidin-1-ylcarbonyl or
morpholin-4-ylcarbonyl group,
a 3-amino-piperidin-1-yl group wherein the piperidin-1-yl moiety in
the 4 position or in the 5 position is additionally substituted by
a hydroxy or methoxy group, a 3-amino-piperidin-1-yl group wherein
the methylene group in the 2 position or in the 6 position is
replaced by a carbonyl group, a piperidin-1-yl or
hexahydroazepin-1-yl group substituted in the 3 position by an
amino, C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)-amino-group,
wherein in each case two hydrogen atoms on the carbon skeleton of
the piperidin-1-yl or hexahydroazepin-1-yl-group are replaced by a
straight-chain alkylene bridge, this bridge containing 2 to 5
carbon atoms if the two hydrogen atoms are located on the same
carbon atom, or 1 to 4 carbon atoms, if the hydrogen atoms are
located on adjacent carbon atoms, or 1 to 4 carbon atoms, if the
hydrogen atoms are located on carbon atoms which are separated by
one atom, or 1 to 3 carbon atoms if the two hydrogen atoms are
located on carbon atoms separated by two atoms, an azetidin-1-yl,
pyrrolidin-1-yl, piperidin-1-yl or hexahydroazepin-1-yl group which
is substituted by an amino-C.sub.1-3-alkyl,
C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)-amino-C.sub.1-3-alkyl group, a piperazin-1-yl
or [1,4]diazepan-1-yl group optionally substituted at the carbon
skeleton by one or two C.sub.1-3-alkyl groups, a
3-imino-piperazin-1-yl, 3-imino-[1,4]diazepan-1-yl or
5-imino-[1,4]diazepan-1-yl group optionally substituted at the
carbon skeleton by one or two C.sub.1-3-alkyl groups, a
[1,4]diazepan-1-yl group optionally substituted by one or two
C.sub.1-3-alkyl groups, which is substituted in the 6 position by
an amino group, a C.sub.3-7-cycloalkyl group which is substituted
by an amino, C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)-amino
group, a C.sub.3-7-cycloalkyl group which is substituted by an
amino-C.sub.1-3-alkyl, C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, a
C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl group wherein the cycloalkyl
moiety is substituted by an amino, C.sub.1-3-alkylamino or
di-(C.sub.1-3-alkyl)-amino group, a
C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl group wherein the cycloalkyl
moiety is substituted by an amino-C.sub.1-3-alkyl,
C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, a
C.sub.3-7-cycloalkylamino group wherein the cycloalkyl moiety is
substituted by an amino, C.sub.1-3-alkylamino or
di-(C.sub.1-3-alkyl)-amino group, while the two nitrogen atoms at
the cycloalkyl moiety are separated from one another by at least
two carbon atoms, an
N--(C.sub.3-7-cycloalkyl)-N--(C.sub.1-3-alkyl)-amino group wherein
the cycloalkyl moiety is substituted by an amino,
C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)-amino group, while the
two nitrogen atoms at the cycloalkyl moiety are separated from one
another by at least two carbon atoms, a C.sub.3-7-cycloalkylamino
group wherein the cycloalkyl moiety is substituted by an
amino-C.sub.1-3-alkyl, C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, an
N--(C.sub.3-7-cycloalkyl)-N--(C.sub.1-3-alkyl)-amino group wherein
the cycloalkyl moiety is substituted by an amino-C.sub.1-3-alkyl,
C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, a
C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl-amino group wherein the
cycloalkyl moiety is substituted by an amino, C.sub.1-3-alkylamino
or di-(C.sub.1-3-alkyl)-amino group, an
N--(C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl)-N--(C.sub.1-2-alkyl)-amino
group wherein the cycloalkyl moiety is substituted by an amino,
C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)-amino group, a
C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl-amino group wherein the
cycloalkyl moiety is substituted by an amino-C.sub.1-3-alkyl,
C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, an
N--(C.sub.3-7-cycloalkyl-C.sub.1-2-alkyl)-N--(C.sub.1-2-alkyl)-amino
group wherein the cycloalkyl moiety is substituted by an
amino-C.sub.1-3-alkyl, C.sub.1-3-alkylamino-C.sub.1-3-alkyl or a
di-(C.sub.1-3-alkyl)amino-C.sub.1-3-alkyl group, a
R.sup.19--C.sub.2-4-alkylamino group wherein R.sup.19 is separated
from the nitrogen atom of the C.sub.2-4-alkylamino moiety by at
least two carbon atoms and [0068] R.sup.19 denotes an amino,
C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)-amino group, an
R.sup.19--C.sub.2-4-alkylamino group wherein the nitrogen atom of
the C.sub.2-4-alkylamino moiety is substituted by a C.sub.1-3-alkyl
group and R.sup.19 is separated from the nitrogen atom of the
C.sub.2-4-alkylamino moiety by at least two carbon atoms, while
R.sup.19 is as hereinbefore defined, an amino group substituted by
the group R.sup.20 wherein [0069] R.sup.20 denotes an
azetidin-3-yl, azetidin-2-ylmethyl, azetidin-3-ylmethyl,
pyrrolidin-3-yl, pyrrolidin-2-ylmethyl, pyrrolidin-3-ylmethyl,
piperidin-3-yl, piperidin-4-yl, piperidin-2-ylmethyl,
piperidin-3-ylmethyl or piperidin-4-ylmethyl group, while the
groups mentioned for R.sup.20 may each be substituted by one or two
C.sub.1-3-alkyl groups, an amino group substituted by the group
R.sup.20 and a C.sub.1-3-alkyl group wherein R.sup.20 is as
hereinbefore defined, while the groups mentioned for R.sup.20 may
each be substituted by one or two C.sub.1-3-alkyl groups, an
R.sup.19--C.sub.3-4-alkyl group wherein the C.sub.3-4-alkyl moiety
is straight-chained and may additionally be substituted by one or
two C.sub.1-3-alkyl groups, while R.sup.19 is as hereinbefore
defined, a 3-amino-2-oxo-piperidin-5-yl or
3-amino-2-oxo-1-methyl-piperidin-5-yl group, a pyrrolidin-3-yl,
piperidin-3-yl, piperidin-4-yl, hexahydroazepin-3-yl or
hexahydroazepin-4-yl group which is substituted in the 1 position
by an amino, C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)amino
group, or an azetidin-2-yl-C.sub.1-2-alkyl,
azetidin-3-yl-C.sub.1-2-alkyl, pyrrolidin-2-yl-C.sub.1-2-alkyl,
pyrrolidin-3-yl, pyrrolidin-3-yl-C.sub.1-2-alkyl,
piperidin-2-yl-C.sub.1-2-alkyl, piperidin-3-yl,
piperidin-3-yl-C.sub.1-2-alkyl, piperidin-4-yl or
piperidin-4-yl-C.sub.1-2-alkyl group, while the above mentioned
groups may each be substituted by one or two C.sub.1-3-alkyl
groups, while by the aryl groups mentioned in the definition of the
above groups are meant phenyl or naphthyl groups which may be mono-
or disubstituted by R.sub.h, while the substituents may be
identical or different and R.sub.h denotes a fluorine, chlorine,
bromine or iodine atom, a trifluoromethyl, cyano, nitro, amino,
aminocarbonyl, aminosulphonyl, methylsulphonyl, acetylamino,
methylsulphonylamino, C.sub.1-3-alkyl, cyclopropyl, ethenyl,
ethynyl, hydroxy, C.sub.1-3-alkyloxy, difluoromethoxy or
trifluoromethoxy group, by the heteroaryl groups mentioned in the
definition of the above groups are meant a pyrrolyl, furanyl,
thienyl, pyridyl, indolyl, benzofuranyl, benzothiophenyl,
quinolinyl or isoquinolinyl group, or a pyrrolyl, furanyl, thienyl
or pyridyl group, wherein one or two methyne groups are replaced by
nitrogen atoms, or an indolyl, benzofuranyl, benzothiophenyl,
quinolinyl or isoquinolinyl group, wherein one to three methyne
groups are replaced by nitrogen atoms, [0070] and the above
mentioned heteroaryl groups may be mono- or disubstituted by
R.sub.h, while the substituents may be identical or different and
R.sub.h is as hereinbefore defined, while, unless otherwise stated,
the above mentioned alkyl, alkenyl and alkynyl groups may be
straight-chain or branched, and the hydrogen atoms of the methyl or
ethyl groups contained in the definitions may be wholly or partly
replaced by fluorine atoms, the tautomers, enantiomers,
diastereomers, the mixtures thereof, the prodrugs thereof and the
salts thereof.
[0071] Compounds of the above general formula I which contain one
or more groups that can be cleaved in vivo are so-called
prodrugs.
[0072] The carboxy groups mentioned in the definition of the above
mentioned groups may be replaced by a group which can be converted
into a carboxy group in vivo or by a group which is negatively
charged under physiological conditions,
and furthermore the amino and imino groups mentioned in the
definition of the above mentioned groups may be substituted by a
group which can be cleaved in vivo. Such groups are described for
example in WO 98/46576 and by N. M. Nielsen et al. in International
Journal of Pharmaceutics 39, 75-85 (1987).
[0073] By a group which can be converted in vivo into a carboxy
group is meant, for example, a hydroxymethyl group, a carboxy group
esterified with an alcohol wherein the alcohol moiety is preferably
a C.sub.1-6-alkanol, a phenyl-C.sub.1-3-alkanol, a
C.sub.3-9-cycloalkanol, while a C.sub.5-8-cycloalkanol may
additionally be substituted by one or two C.sub.1-3-alkyl groups, a
C.sub.5-8-cycloalkanol wherein a methylene group in the 3 or 4
position is replaced by an oxygen atom or by an imino group
optionally substituted by a C.sub.1-3-alkyl,
phenyl-C.sub.1-3-alkyl, phenyl-C.sub.1-3-alkyloxycarbonyl or
C.sub.2-6-alkanoyl group and the cycloalkanol moiety may
additionally be substituted by one or two C.sub.1-3-alkyl groups, a
C.sub.4-7-cycloalkenol, a C.sub.3-5-alkenol, a
phenyl-C.sub.3-5-alkenol, a C.sub.3-5-alkynol or
phenyl-C.sub.3-5-alkynol with the proviso that no bonds to the
oxygen atom start from a carbon atom which carries a double or
triple bond, a C.sub.3-8-cycloalkyl-C.sub.1-3-alkanol, a
bicycloalkanol with a total of 8 to 10 carbon atoms which may
additionally be substituted in the bicycloalkyl moiety by one or
two C.sub.1-3-alkyl groups, a 1,3-dihydro-3-oxo-1-isobenzofuranol
or an alcohol of formula
R.sub.p--CO--O--(R.sub.qCR.sub.r)--OH,
wherein [0074] R.sub.p denotes a C.sub.1-8-alkyl,
C.sub.5-7-cycloalkyl, C.sub.1-8-alkyloxy, C.sub.5-7-cycloalkyloxy,
phenyl or phenyl-C.sub.1-3-alkyl group, [0075] R.sub.q denotes a
hydrogen atom, a C.sub.1-3-alkyl, C.sub.5-7-cycloalkyl or phenyl
group and [0076] R.sub.r denotes a hydrogen atom or a
C.sub.1-3-alkyl group, by a group which is negatively charged under
physiological conditions is meant, for example, a tetrazol-5-yl,
phenylcarbonylaminocarbonyl, trifluoromethylcarbonylaminocarbonyl,
C.sub.1-6-alkylsulphonylamino, phenylsulphonylamino,
benzylsulphonylamino, trifluoromethyl-sulphonylamino,
C.sub.1-6-alkylsulphonylaminocarbonyl,
phenylsulphonylaminocarbonyl, benzylsulphonylaminocarbonyl or
perfluoro-C.sub.1-6-alkylsulphonylaminocarbonyl group and by a
group which can be cleaved in vivo from an imino or amino group is
meant, for example, a hydroxy group, an acyl group such as a
phenylcarbonyl group optionally mono- or disubstituted by fluorine,
chlorine, bromine or iodine atoms, by C.sub.1-3-alkyl or
C.sub.1-3-alkyloxy groups, while the substituents may be identical
or different, a pyridinoyl group or a C.sub.1-16-alkanoyl group
such as the formyl, acetyl, propionyl, butanoyl, pentanoyl or
hexanoyl group, a 3,3,3-trichloropropionyl or allyloxycarbonyl
group, a C.sub.1-16-alkyloxycarbonyl or C.sub.1-6-alkylcarbonyloxy
group, wherein hydrogen atoms may be wholly or partially replaced
by fluorine or chlorine atoms such as the methoxycarbonyl,
ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl,
butoxycarbonyl, tert.butoxycarbonyl, pentoxycarbonyl,
hexoxycarbonyl, octyloxycarbonyl, nonyloxycarbonyl,
decyloxycarbonyl, undecyloxycarbonyl, dodecyloxycarbonyl,
hexadecyloxycarbonyl, methylcarbonyloxy, ethylcarbonyloxy,
2,2,2-trichloroethylcarbonyloxy, propylcarbonyloxy,
isopropylcarbonyloxy, butylcarbonyloxy, tert.butylcarbonyloxy,
pentylcarbonyloxy, hexylcarbonyloxy, octylcarbonyloxy,
nonylcarbonyloxy, decylcarbonyloxy, undecylcarbonyloxy,
dodecylcarbonyloxy or hexadecylcarbonyloxy group, a
phenyl-C.sub.1-6-alkyloxycarbonyl group such as the
benzyloxycarbonyl, phenylethoxycarbonyl or phenylpropoxycarbonyl
group, a 3-amino-propionyl group wherein the amino group may be
mono- or disubstituted by C.sub.1-6-alkyl or C.sub.3-7-cycloalkyl
groups and the substituents may be identical or different, a
C.sub.1-3-alkylsulphonyl-C.sub.2-4-alkyloxycarbonyl,
C.sub.1-3-alkyloxy-C.sub.2-4-alkyloxy-C.sub.2-4-alkyloxycarbonyl,
R.sub.p--CO--O--(R.sub.qCR.sub.r)--O--CO,
C.sub.1-6-alkyl-CO--NH--(R.sub.sCR.sub.t)--O--CO or
C.sub.1-6-alkyl-CO--O--(R.sub.sCR.sub.t)--(R.sub.sCR.sub.t)--O--CO
group, wherein R.sub.p to R.sub.r are as hereinbefore defined,
[0077] R.sub.s, and R.sub.t, which may be identical or different,
denote hydrogen atoms or C.sub.1-3-alkyl groups.
[0078] Moreover, the saturated alkyl and alkyloxy moieties which
contain more than 2 carbon atoms mentioned in the foregoing
definitions and those that follow, unless otherwise stated, also
include the branched isomers thereof such as, for example, the
isopropyl, tert.butyl, isobutyl group, etc.
[0079] Preferred compounds of the above general formula I are those
wherein
R.sup.1 denotes a methyl group substituted by a group R.sub.a,
where [0080] R.sub.a denotes a 3,4-dihydro-quinolinyl group, [0081]
a 3,4-dihydro-isoquinolinyl group, [0082] a
1,4-dihydro-quinazolinyl or 4-oxo-1,4-dihydro-quinazolinyl group,
[0083] a 3,4-dihydro-quinazolinyl or 4-oxo-3,4-dihydro-quinazolinyl
group, [0084] a 1H-benzo[d][1,2]oxazinyl or
1-oxo-1H-benzo[d][1,2]oxazinyl group, [0085] a
4H-benzo[e][1,3]oxazinyl or 4-oxo-4H-benzo[e][1,3]oxazinyl group,
[0086] a 4H-benzo[d][1,3]oxazinyl or 4-oxo-4H-benzo[d][1,3]oxazinyl
group, [0087] a 2H-benzo[1,4]oxazinyl or
2-oxo-2H-benzo[1,4]oxazinyl group, [0088] a
4H-benzo[e][1,3]thiazinyl or 4-oxo-4H-benzo[e][1,3]thiazinyl group,
[0089] a 4H-benzo[d][1,3]thiazinyl or 2H-benzo[1,4]thiazinyl group,
[0090] a 2-oxo-2H-benzo[e][1,3]oxazinyl or
2,2-dioxo-1H-benzo[c][1,2]thiazinyl group, [0091] a
2,3-dihydro-1H-benzo[e][1,4]diazepinyl or
2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepinyl group, [0092] a
4,5-dihydro-3H-benzo[b][1,4]diazepinyl or
4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepinyl group, [0093] a
5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepinyl group, [0094] a
2,3-dihydro-benzo[f][1,4]oxazepinyl or
2,3-dihydro-benzo[b][1,4]oxazepinyl group, [0095] a
2,3-dihydro-benzo[f][1,4]thiazepinyl or
2,3-dihydro-benzo[b][1,4]thiazepinyl group, [0096] a
5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepinyl group, [0097] a
11H-dibenzo[b,e]azepinyl or 11-oxo-11H-dibenzo[b,e]azepinyl group,
[0098] a 11H-benzo[e]pyrido[3,2-b]azepinyl or a
5H-1,9,10-triaza-dibenzo[a,d]cycloheptenyl group, [0099] a
5H-dibenzo[b,e][1,4]diazepinyl or dibenzo[b,f][1,4]oxazepinyl
group, [0100] a dibenzo[b,f][1,4]thiazepinyl,
5-oxo-dibenzo[b,f][1,4]thiazepinyl or
5,5-dioxo-dibenzo[b,f][1,4]thiazepinyl group, [0101] a
5H-dibenzo[a,d]cycloheptenyl or 5H-dibenzo[b,f]azepinyl group,
[0102] a phenanthridinyl, benzo[c][1,5]naphthyridinyl,
benzo[h][1,6]naphthyridinyl, benzo[c][1,8]naphthyridinyl,
benzo[f][1,7]naphthyridinyl or 1,5,9-triaza-phenanthrenyl group,
[0103] a 1,2,3,4-tetrahydro-phenanthridinyl,
1,2,3,4,4a,10b-hexahydro-phenanthridinyl,
2,3-dihydro-1H-4-aza-cyclopenta[a]naphthyl or
8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphthyl group, [0104] a
2,3-dihydro-1H-4-oxa-10-aza-phenanthrenyl or
1-oxo-2,3-dihydro-1H-4-oxa-10-aza-phenanthrenyl group, [0105] a
phenanthrenyl, benzo[h]quinolinyl, benzo[f]quinolinyl or
benzo[f]quinoxalinyl group, [0106] a
5H-benzo[e]pyrrolo[1,2-a][1,4]diazepinyl,
thieno[3,2-b][1,4]benzoxazepinyl, 5H-dibenzo[d,f][1,3]diazepinyl or
5-oxa-7-aza-dibenzo[a,c]cycloheptenyl group, [0107] a
naphtho[1,2-d]oxazolyl, naphtho[2,1-d]oxazolyl,
naphtho[1,2-d]thiazolyl, naphtho[2,1-d]thiazolyl,
naphtho[1,2-d]imidazolyl, naphtho[1,2-b]furanyl or
naphtho[2,1-b]furanyl group, [0108] or a furo[3,2-c]isoquinolinyl,
pyrazolo[1,5-c]quinazolinyl or 1H-perimidinyl group, [0109] while
the benzo groups of the above mentioned radicals R.sub.a are
substituted by the groups R.sup.10 to R.sup.13 and the alkylene
units of the above mentioned groups R.sub.a may be substituted by
one or two fluorine atoms or one or two C.sub.1-3-alkyl or
C.sub.1-3-alkyloxy-carbonyl groups and the imino groups of the
above mentioned radicals R.sub.a may be substituted by a
C.sub.1-3-alkyl group and [0110] R.sup.10 denotes a hydrogen atom,
[0111] a fluorine, chlorine, bromine or iodine atom, [0112] a
C.sub.1-3-alkyl or cyclopropyl group, [0113] a hydroxy,
C.sub.1-3-alkyloxy or cyclopropyloxy group, [0114] a nitro, amino,
C.sub.1-3-alkylamino or di-(C.sub.1-3-alkyl)amino group, [0115] a
C.sub.1-3-alkyl-carbonylamino or C.sub.1-3-alkyl-sulphonylamino
group, [0116] a cyano, carboxy, C.sub.1-3-alkyloxy-carbonyl,
aminocarbonyl, C.sub.1-3-alkyl-aminocarbonyl or
di-(C.sub.1-3-alkyl)-aminocarbonyl group, [0117] a mercapto,
C.sub.1-3-alkylsulphanyl, C.sub.1-3-alkysulphinyl,
C.sub.1-3-alkylsulphonyl or aminosulphonyl group or [0118] a
difluoromethyl, trifluoromethyl, difluoromethoxy or
trifluoromethoxy group and [0119] R.sup.11, R.sup.12 and R.sup.13,
which may be identical or different, in each case represent a
hydrogen atom, a fluorine, chlorine or bromine atom, a methyl,
trifluoromethyl or methoxy group, R.sup.2 denotes a hydrogen atom
or a C.sub.1-3-alkyl, cyclopropyl, trifluoromethyl, cyanomethyl or
2-cyano-ethyl group, Y denotes a nitrogen atom or a group of
formula C--R.sup.5, [0120] while R.sup.5 denotes a hydrogen atom or
a C.sub.1-3-alkyl group, R.sup.3 denotes a 2-buten-1-yl or
3-methyl-2-buten-1-yl group, a 1-buten-1-yl group, a 2-butyn-1-yl
group or a 1-cyclopenten-1-ylmethyl group and R.sup.4 denotes a
(3-amino-piperidin-1-yl) group, while, unless otherwise stated, the
above mentioned alkyl groups may be straight-chain or branched, the
tautomers, enantiomers, diastereomers, the mixtures thereof and the
salts thereof.
[0121] Particularly preferred are those compounds of the above
general formula I wherein
R.sup.1 denotes a methyl group substituted by a group R.sub.a,
where [0122] R.sub.a denotes a 3,4-dihydro-quinolin-2-yl group,
[0123] a 3,4-dihydro-isoquinolin-1-yl group, [0124] a
1,4-dihydro-quinazolin-2-yl or 4-oxo-1,4-dihydro-quinazolin-2-yl
group, [0125] a 3,4-dihydro-quinazolin-2-yl or
4-oxo-3,4-dihydro-quinazolin-2-yl group, [0126] a
1H-benzo[d][1,2]oxazin-4-yl or 1-oxo-1H-benzo[d][1,2]oxazin-4-yl
group, [0127] a 4H-benzo[e][1,3]oxazin-2-yl or
4-oxo-4H-benzo[e][1,3]oxazin-2-yl group, [0128] a
4H-benzo[d][1,3]oxazin-2-yl or 4-oxo-4H-benzo[d][1,3]oxazin-2-yl
group, [0129] a 2H-benzo[1,4]oxazin-3-yl or
2-oxo-2H-benzo[1,4]oxazin-3-yl group, [0130] a
4H-benzo[e][1,3]thiazin-2-yl or 4-oxo-4H-benzo[e][1,3]thiazin-2-yl
group, [0131] a 4H-benzo[d][1,3]thiazin-2-yl or
2H-benzo[1,4]thiazin-3-yl group, [0132] a
2-oxo-2H-benzo[e][1,3]oxazin-4-yl or
2,2-dioxo-1H-benzo[c][1,2]thiazin-4-yl group, [0133] a
2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl or
2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl group, [0134] a
4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl or
4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl group, [0135] a
5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-yl group, [0136] a
2,3-dihydro-benzo[f][1,4]oxazepin-5-yl or
2,3-dihydro-benzo[b][1,4]oxazepin-4-yl group, [0137] a
2,3-dihydro-benzo[f][1,4]thiazepin-5-yl or
2,3-dihydro-benzo[b][1,4]thiazepin-4-yl group, [0138] a
5-oxo-4,5-dihydro-benzo[f][1,3,4]oxadiazepin-2-yl group, [0139] a
11H-dibenzo[b,e]azepin-6-yl or 11-oxo-11H-dibenzo[b,e]azepin-6-yl
group, [0140] a 11H-benzo[e]pyrido[3,2-b]azepin-6-yl or a
5H-1,9,10-triaza-dibenzo[a,d]-cyclohepten-11-yl group, [0141] a
5H-dibenzo[b,e][1,4]diazepin-11-yl or
dibenzo[b,f][1,4]oxazepin-11-yl group, [0142] a
dibenzo[b,f][1,4]thiazepin-11-yl,
5-oxo-dibenzo[b,f][1,4]thiazepin-11-yl or
5,5-dioxo-dibenzo[b,f][1,4]thiazepin-11-yl group, [0143] a
5H-dibenzo[a,d]cyclohepten-10-yl or 5H-dibenzo[b,f]azepin-10-yl
group, [0144] a phenanthridin-6-yl, benzo[c][1,5]naphthyridin-6-yl,
benzo[h][1,6]naphthyridin-5-yl, benzo[c][1,8]naphthyridin-6-yl,
benzo[f][1,7]naphthyridin-5-yl or 1,5,9-triaza-phenanthren-10-yl
group, [0145] a 1,2,3,4-tetrahydro-phenanthridin-6-yl,
1,2,3,4,4a,10b-hexahydro-phenanthridin-6-yl,
2,3-dihydro-1H-4-aza-cyclopenta[a]naphth-5-yl or
8,9,10,11-tetrahydro-7H-6-aza-cyclohepta[a]naphth-5-yl group,
[0146] a 2,3-dihydro-1H-4-oxa-10-aza-phenanthren-9-yl or
1-oxo-2,3-dihydro-1H-4-oxa-10-aza-phenanthren-9-yl group, [0147] a
phenanthren-9-yl, benzo[h]quinolin-6-yl, benzo[f]quinolin-6-yl or
benzo[f]quinoxalin-6-yl group, [0148] a
5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-11-yl,
thieno[3,2-b][1,4]benzoxazepin-9-yl,
5H-dibenzo[d,f][1,3]diazepin-6-yl or
5-oxa-7-aza-dibenzo[a,c]cyclohepten-6-yl group, [0149] a
naphtho[1,2-d]oxazol-2-yl, naphtho[2,1-d]oxazol-2-yl,
naphtho[1,2-d]thiazol-2-yl, naphtho[2,1-d]thiazol-2-yl,
naphtho[1,2-d]imidazol-2-yl, naphtho[1,2-b]furan-2-yl or
naphtho[2,1-b]furan-2-yl group, [0150] or a
furo[3,2-c]isoquinolin-5-yl, pyrazolo[1,5-c]quinazolin-5-yl or
1H-perimidin-2-yl group, [0151] while the benzo groups of the above
mentioned radicals R.sub.a are substituted by the groups R.sup.10
to R.sup.13 and the alkylene units of the above mentioned groups
R.sub.a may be substituted by one or two fluorine atoms or one or
two methyl groups and the imino groups of the above mentioned
radicals R.sub.a may be substituted by a methyl group and [0152]
R.sup.10 denotes a hydrogen atom, [0153] a fluorine, chlorine,
bromine or iodine atom, [0154] a methyl or ethyl group, [0155] a
hydroxy, methoxy or ethoxy group or [0156] a difluoromethyl,
trifluoromethyl, difluoromethoxy, or trifluoromethoxy group and
[0157] R.sup.11, R.sup.12 and R.sup.13, which may be identical or
different, each denote a hydrogen, fluorine, chlorine or bromine
atom or a methyl, trifluoromethyl or methoxy group, R.sup.2 denotes
a hydrogen atom or a methyl, cyanomethyl, trifluoromethyl, ethyl,
2-cyano-ethyl, propyl, cyclopropyl or isopropyl group, Y denotes a
nitrogen atom or a group of formula C--R.sup.5, [0158] while
R.sup.5 denotes a hydrogen atom or a methyl, ethyl, propyl or
isopropyl group, R.sup.3 denotes a 2-buten-1-yl or
3-methyl-2-buten-1-yl group, a 1-buten-1-yl group, a 2-butyn-1-yl
group or a 1-cyclopenten-1-ylmethyl group and R.sup.4 denotes a
(3-amino-piperidin-1-yl) group, the tautomers, enantiomers,
diastereomers, the mixtures thereof and the salts thereof.
[0159] Most particularly preferred are those compounds of the above
general formula I wherein
R.sup.1 denotes a 4-oxo-3,4-dihydro-quinazolin-2-ylmethyl group, a
dibenzo[b,f][1,4]oxazepin-11-ylmethyl group, a
phenanthridin-6-ylmethyl group, a phenanthren-9-ylmethyl group or a
naphtho[1,2-d]oxazol-2-ylmethyl or naphtho[2,1-d]oxazol-2-ylmethyl
group, R.sup.2 denotes a hydrogen atom or a methyl group, Y denotes
a nitrogen atom, R.sup.3 denotes a 2-butyn-1-yl group and R.sup.4
denotes a (3-amino-piperidin-1-yl) group, the tautomers,
enantiomers, diastereomers, the mixtures thereof and the salts
thereof.
[0160] The following compounds of general formula I deserve special
mention: [0161] (1)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-
-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0161] ##STR00003## [0162] (2)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthridin-6-yl)methyl-
]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0162] ##STR00004## [0163] (3)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthren-9-yl)methyl]--
3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0163] ##STR00005## [0164] (4)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthridin-6-yl)me-
thyl]-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0164] ##STR00006## [0165] (5)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxaz-
epin-11-yl)methyl]-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0165] ##STR00007## [0166] (6)
2-((S)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxaz-
epin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0166] ##STR00008## [0167] (7)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxaz-
epin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0167] ##STR00009## [0168] (8)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(naphtho[2,1-d]oxazol--
2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0168] ##STR00010## [0169] (9)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(naphtho[1,2-d]oxazol--
2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0169] ##STR00011## [0170] (10)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(4-oxo-3,4-dihydro-qui-
nazolin-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
##STR00012##
[0170] the enantiomers, the mixtures thereof and the salts thereof.
According to the invention the compounds of general formula I are
obtained by methods known per se, for example by the following
methods: a) deprotecting a compound of general formula
##STR00013##
wherein R.sup.1, R.sup.2, Y and R.sup.3 are as hereinbefore defined
and R.sup.4'' denotes one of the groups mentioned for R.sup.4
hereinbefore which contain an imino, amino or alkylamino group,
while the imino, amino or alkylamino group is substituted by a
protective group.
[0171] The liberating of an amino group from a protected precursor
is a standard reaction in synthetic organic chemistry. There are
many examples of suitable protective groups. A summary of the
chemistry of protective groups can be found in Theodora W. Greene
and Peter G. M. Wuts, Protective Groups in Organic Synthesis,
Second Edition, 1991, published by John Wiley and Sons, and in
Philip J. Kocienski, Protecting Groups, published by Georg Thieme,
1994.
[0172] The following are examples of protective groups:
the tert.-butyloxycarbonyl group which can be cleaved by treating
with an acid such as for example trifluoroacetic acid or
hydrochloric acid or by treating with bromotrimethylsilane or
iodotrimethylsilane, optionally using a solvent such as methylene
chloride, ethyl acetate, dioxane, methanol, isopropanol or
diethylether at temperatures between 0.degree. C. and 80.degree.
C., the 2,2,2-trichloroethoxycarbonyl group which can be cleaved by
treating with metals such as for example zinc or cadmium in a
solvent such as acetic acid or a mixture of tetrahydrofuran and a
weak aqueous acid at temperatures between 0.degree. C. and the
boiling temperature of the solvent used and the
carbobenzyloxycarbonyl group which can be cleaved for example by
hydrogenolysis in the presence of a noble metal catalyst such as
for example palladium-charcoal and a solvent such as for example
alcohols, ethyl acetate, dioxane, tetrahydrofuran or mixtures of
these solvents at temperatures between 0.degree. C. and the boiling
point of the solvent, by treating with boron tribromide in
methylene chloride at temperatures between -20.degree. C. and
ambient temperature, or by treating with aluminium chloride/anisol
at temperatures between 0.degree. C. and ambient temperature.
[0173] Moreover, the compounds of general formula I obtained may be
resolved into their enantiomers and/or diastereomers, as mentioned
hereinbefore. Thus, for example, cis/trans mixtures may be resolved
into their cis and trans isomers, and compounds with at least one
stereocentre may be separated into their enantiomers.
[0174] Thus, for example, the cis/trans mixtures obtained may be
resolved by chromatography into the cis and trans isomers thereof,
the compounds of general formula I obtained which occur as
racemates may be separated by methods known per se (cf. Allinger N.
L. and Eliel E. L. in "Topics in Stereochemistry", Vol. 6, Wiley
Interscience, 1971) into their optical antipodes and compounds of
general formula I with at least 2 asymmetric carbon atoms may be
resolved into their diastereomers on the basis of their
physical-chemical differences using methods known per se, e.g. by
chromatography and/or fractional crystallisation, and, if these
compounds are obtained in racemic form, they may subsequently be
resolved into the enantiomers as mentioned above.
[0175] The enantiomers are preferably separated by column
separation on chiral phases or by recrystallisation from an
optically active solvent or by reacting with an optically active
substance which forms salts or derivatives such as e.g. esters or
amides with the racemic compound, particularly acids and the
activated derivatives or alcohols thereof, and separating the
diastereomeric mixture of salts or derivatives thus obtained, e.g.
on the basis of their differences in solubility, whilst the free
antipodes may be released from the pure diastereomeric salts or
derivatives by the action of suitable agents. Optically active
acids in common use are e.g. the D- and L-forms of tartaric acid or
dibenzoyltartaric acid, di-O-p-toluoyltartaric acid, malic acid,
mandelic acid, camphorsulphonic acid, glutamic acid, aspartic acid
or quinic acid. An optically active alcohol may be for example (+)-
or (-)-menthol and an optically active acyl group in amides, for
example, may be a (+)- or (-)-menthyloxycarbonyl.
[0176] Furthermore, the compounds of formula I obtained may be
converted into the salts thereof, particularly for pharmaceutical
use into the physiologically acceptable salts with inorganic or
organic acids. Acids which may be used for this purpose include for
example hydrochloric acid, hydrobromic acid, sulphuric acid,
methanesulphonic acid, phosphoric acid, fumaric acid, succinic
acid, lactic acid, citric acid, tartaric acid or maleic acid.
[0177] Moreover, if the new compounds of formula I thus obtained
contain a carboxy group, they may subsequently, if desired, be
converted into the salts thereof with inorganic or organic bases,
particularly for pharmaceutical use into the physiologically
acceptable salts thereof. Suitable bases for this purpose include
for example sodium hydroxide, potassium hydroxide, arginine,
cyclohexylamine, ethanolamine, diethanolamine and
triethanolamine.
[0178] The compounds of general formula II used as starting
materials are either known from the literature or may be obtained
by methods known from the literature (cf. Examples I to XVI).
[0179] As already mentioned hereinbefore, the compounds of general
formula I according to the invention and the physiologically
acceptable salts thereof have valuable pharmacological properties,
particularly an inhibiting effect on the enzyme DPP-IV.
[0180] The biological properties of the new compounds were
investigated as follows:
[0181] The ability of the substances and their corresponding salts
to inhibit the DPP-IV activity can be demonstrated in a test set-up
in which an extract of human colon carcinoma cell line Caco-2 is
used as the DPP IV source. The differentiation of the cells in
order to induce the DPP-IV expression was carried out as described
by Reiher et al. in an article entitled "Increased expression of
intestinal cell line Caco-2", which appeared in Proc. Natl. Acad.
Sci. Vol. 90, pages 5757-5761 (1993). The cell extract was obtained
from cells solubilised in a buffer (10 mM Tris HCl, 0.15 M NaCl,
0.04 t.i.u. aprotinin, 0.5% Nonidet-P40, pH 8.0) by centrifuging at
35,000 g for 30 minutes at 4.degree. C. (to remove cell
debris).
[0182] The DPP-IV assay was carried out as follows:
[0183] 50 .mu.l substrate solution (AFC; AFC is
amido-4-trifluoromethylcoumarin), final concentration 100 .mu.M,
were placed in black microtitre plates. 20 .mu.l of assay buffer
(final concentrations 50 mM Tris HCl pH 7.8, 50 mM NaCl, 1% DMSO)
was pipetted in. The reaction was started by adding 30 .mu.l of
solubilised Caco-2 protein (final concentration 0.14 .mu.g of
protein per well). The test substances to be investigated were
typically added prediluted in 20 .mu.l, and the volume of assay
buffer was then reduced accordingly. The reaction was carried out
at ambient temperature, incubating for 60 minutes. Then the
fluorescence was measured in a Victor 1420 Multilabel Counter, the
excitation wavelength being 405 nm and the emission wavelength
being 535 nm. Blank readings (corresponding to 0% activity) were
obtained in mixtures without any Caco-2 protein (volume replaced by
assay buffer), control values (corresponding to 100% activity) were
obtained in mixtures with no substance added. The potency of the
test substances in question, expressed as IC.sub.50 values, was
calculated from dosage/activity curves consisting of 11 measuring
points in each case. The following results were obtained:
TABLE-US-00001 Compound DPP IV inhibition (Example No.) IC.sub.50
[nM] 1 14 1(1) 17 1(2) 58 1(3) 8 1(4) 9 1(7) 3 1(8) 7 1(9) 3
[0184] The compounds prepared according to the invention are well
tolerated, as for example when 10 mg/kg of the compound of Example
1 were administered to rats by oral route no changes in the
animals' behaviour could be detected.
[0185] In view of their ability to inhibit DPP-IV activity, the
compounds of general formula I according to the invention and the
corresponding pharmaceutically acceptable salts thereof are
suitable for treating all those conditions or illnesses which can
be influenced by the inhibition of the DPP-IV activity. It is
therefore to be expected that the compounds according to the
invention will be suitable for the prevention or treatment of
diseases or conditions such as type I and type II diabetes
mellitus, diabetic complications, metabolic acidosis or ketosis,
insulin resistance, dyslipidaemias of various origins, arthritis,
atherosclerosis and related diseases, obesity, allograft
transplantation and calcitonin-induced osteoporosis. In addition
these substances are capable of preventing B-cell degeneration such
as e.g. apoptosis or necrosis of pancreatic B-cells. The substances
are also suitable for improving or restoring the function of
pancreatic cells and also increasing the number and size of
pancreatic B-cells. Additionally, and on the basis of the role of
the Glucagon-Like Peptides, such as e.g. GLP-1 and GLP-2 and their
link with DPP-IV inhibition, it is likely that the compounds
according to the invention are suitable for achieving, inter alia,
a sedative or anxiety-relieving effect and also of favourably
affecting catabolic states after operations or hormonal stress
responses or of reducing mortality or morbidity after myocardial
infarct. They are also suitable for treating all conditions which
are connected with the above mentioned effects and which are
mediated by GLP-1 or GLP-2. The compounds according to the
invention may also be used as diuretics or antihypertensives and
are suitable for preventing and treating acute renal failure. They
are also suitable for the prevention and treatment of chronic
inflammatory intestinal diseases. It is also expected that DPP-IV
inhibitors and hence also the compounds according to the invention
may be used to treat infertility or to improve fertility in humans
or mammals, particularly when the infertility is connected with
insulin resistance or polycystic ovary syndrome. The substances are
also suitable for treating deficiencies of growth hormone which are
associated with reduced stature.
[0186] The compounds according to the invention may also be used in
conjunction with other active substances. Therapeutic agents which
are suitable for such combinations include, for example,
antidiabetics, such as metformin, sulphonylureas (e.g.
glibenclamide, tolbutamide, glimepiride), nateglinide, repaglinide,
thiazolidinedione (e.g. rosiglitazone, pioglitazone), PPAR-gamma
agonists (e.g. GI 262570), alpha-glucosidase inhibitors (e.g.
acarbose, voglibose), alpha2 antagonists, insulin and insulin
analogues, GLP-1 and GLP-1 analogues (e.g. exendin-4) or amylin.
Also, inhibitors of protein tyrosine phosphatase 1, substances
which influence deregulated glucose production in the liver, such
as e.g. inhibitors of glucose-6-phosphatase, or
fructose-1,6-bisphosphatase, glycogen phosphorylase, glucagon
receptor antagonists and inhibitors of phosphoenol pyruvate
carboxykinase, glycogen synthase kinase or pyruvate dehydrokinase,
lipid lowering agents, such as HMG-CoA-reductase inhibitors (e.g.
simvastatin, atorvastatin), fibrates (e.g. bezafibrate,
fenofibrate), nicotinic acid and its derivatives, cholesterol
absorption inhibitors such as for example ezetimibe, bile
acid-binding substances such as for example cholestyramine,
HDL-raising compounds such as for example inhibitors of CETP or
regulators of ABC1 or active substances for the treatment of
obesity, such as e.g. sibutramine or tetrahydrolipostatin, or
.beta..sub.3-agonists such as SB-418790 or AD-9677.
[0187] It is also possible to combine the compounds with drugs for
treating high blood pressure such as e.g. AII antagonists or ACE
inhibitors, diuretics, .beta.-blockers, etc., or combinations
thereof.
[0188] The dosage required to achieve such an effect is
expediently, by intravenous route, 1 to 100 mg, preferably 1 to 30
mg, and by oral route 1 to 1000 mg, preferably 1 to 100 mg, in each
case 1 to 4 times a day. For this purpose, the compounds of formula
I prepared according to the invention, optionally combined with
other active substances, may be incorporated together with one or
more inert conventional carriers and/or diluents, e.g. with corn
starch, lactose, glucose, microcrystalline cellulose, magnesium
stearate, polyvinylpyrrolidone, citric acid, tartaric acid, water,
water/ethanol, water/glycerol, water/sorbitol, water/polyethylene
glycol, propylene glycol, cetylstearyl alcohol,
carboxymethylcellulose or fatty substances such as hard fat or
suitable mixtures thereof into conventional galenic preparations
such as plain or coated tablets, capsules, powders, suspensions or
suppositories.
[0189] The Examples that follow are intended to illustrate the
invention:
[0190] Preparation of the starting compounds:
EXAMPLE I
2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(di-
benzo[b,f][1,4]-oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-
-4-one
[0191] 317 mg 11-chloromethyl-dibenzo[b,f][1,4]oxazepin are added
to 400 mg
2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-3,-
5-dihydro-imidazo[4,5-d]pyridazin-4-one and 276 mg potassium
carbonate in 4 ml N,N-dimethylformamide. The reaction mixture is
stirred for two hours at 80.degree. C. For working up it is
combined with water and the precipitate formed is suction filtered.
The crude product is purified by chromatography over a silica gel
column with methylene chloride/methanol (100:0 to 70:30) as
eluant.
[0192] Yield: 120 mg (20% of theory)
[0193] Mass spectrum (ESI.sup.+): m/z=594 [M+H].sup.+
[0194] The following compounds are obtained analogously to Example
I: [0195] (1)
2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(p-
henanthridin-6-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0196] (2)
2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-
-[(phenanthren-9-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0197] (3)
2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-
-[(phenanthridin-6-yl)methyl]-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-
-4-one
[0198] R.sub.f value: 0.41 (silica gel, cyclohexane/ethyl
acetate=3:7)
[0199] Mass spectrum (ESI.sup.+): m/z=592 [M+H].sup.+ [0200] (4)
2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-
-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-7-methyl-3,5-dihydro-imidazo[4,-
5-d]pyridazin-4-one
[0201] R.sub.f value: 0.50 (silica gel, cyclohexane/ethyl
acetate=2:8)
[0202] Mass spectrum (ESI.sup.+): m/z=608 [M+H].sup.+ [0203] (5)
2-bromo-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5--
dihydro-imidazo[4,5-d]pyridazin-4-one
[0204] Mass spectrum (ESI.sup.+): m/z=474, 476 [M+H].sup.+ [0205]
(6)
2-bromo-3-(2-butyn-1-yl)-5-[(naphtho[2,1-d]oxazol-2-yl)methyl]-3,5-dihydr-
o-imidazo[4,5-d]pyridazin-4-one
[0206] R.sub.f value: 0.80 (silica gel, methylene
chloride/ethanol=9:1) [0207] (7)
2-bromo-3-(2-butyn-1-yl)-5-[(naphtho[1,2-d]oxazol-2-yl)methyl]-3,5-dihydr-
o-imidazo[4,5-d]pyridazin-4-one
[0208] R.sub.f value: 0.50 (silica gel, methylene
chloride/methanol=19:1) [0209] (8)
2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-
-cyanomethyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0210] R.sub.f value: 0.40 (silica gel, petroleum ether/ethyl
acetate=1:4)
[0211] Mass spectrum (ESI.sup.+): m/z=426 [M+H].sup.+
EXAMPLE II
2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-3,5-di-
hydro-imidazo[4,5-d]pyridazin-4-one
[0212] 2.50 g 3-(tert.-butyloxycarbonylamino)-piperidine are added
to 2.65 g
2-bromo-3-(2-butyn-1-yl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
and 2.12 g sodium carbonate in 5 ml dimethylsulphoxide. The
reaction mixture is stirred overnight at 85.degree. C.
[0213] After cooling to ambient temperature it is combined with
water and extracted with ethyl acetate. The combined organic phases
are dried over magnesium carbonate and evaporated down. The crude
product is further reacted without any further purification.
[0214] Mass spectrum (ESI.sup.+): m/z=387 [M+H].sup.+
[0215] The following compounds are obtained analogously to Example
II: [0216] (1)
2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-7-
-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0217] R.sub.f value: 0.15 (silica gel, cyclohexane/ethyl
acetate=3:7)
[0218] Mass spectrum (ESI.sup.+): m/z=401 [M+H].sup.+ [0219] (2)
2-[(S)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-
-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyrid-
azin-4-one
[0220] Mass spectrum (ESI.sup.+): m/z=594 [M+H].sup.+ [0221] (3)
2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-
-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyrid-
azin-4-one
[0222] Mass spectrum (ESI.sup.+): m/z=594 [M+H].sup.+ [0223] (4)
2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-
-[(naphtho[2,1-d]oxazol-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-
-one
[0224] R.sub.f value: 0.70 (silica gel, methylene
chloride/ethanol=9:1) [0225] (5)
2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-
-[(naphtho[1,2-d]oxazol-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-
-one
[0226] R.sub.f value: 0.65 (silica gel, methylene
chloride/methanol=9:1)
[0227] Mass spectrum (ESI.sup.+): m/z=568 [M+H].sup.+ [0228] (6)
2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-3-
,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0229] Mass spectrum (ESI.sup.+): m/z=387 [M+H].sup.+
[0230] R.sub.f value: 0.50 (silica gel, methylene
chloride/ethanol=9:1)
EXAMPLE III
2-bromo-3-(2-butyn-1-yl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0231] 0.63 ml hydrazine hydrate are added dropwise to 3.68 g
methyl 2-bromo-3-(2-butyn-1-yl)-5-formyl-3H-imidazole-4-carboxylate
in 50 ml of ethanol. The reaction mixture is stirred for one hour
at ambient temperature, then 3 ml acetic acid are added and the
reaction mixture is refluxed for a further hour. The precipitate
formed is suction filtered, washed with ethanol and diethyl ether
and dried.
[0232] Yield: 2.65 g (77% of theory)
[0233] Mass spectrum (ESI.sup.+): m/z=267, 269 [M+H].sup.+
EXAMPLE IV
methyl
2-bromo-3-(2-butyn-1-yl)-5-formyl-3H-imidazole-4-carboxylate
[0234] 45 ml diisobutylaluminum hydride solution (1M in toluene)
are added dropwise to 12.45 g dimethyl
2-bromo-3-(2-butyn-1-yl)-1H-imidazole-4,5-dicarboxylate in 150 ml
of tetrahydrofuran under an argon atmosphere at -65.degree. C. The
reaction mixture is stirred for two hours at -65.degree. C., then
another 9 ml diisobutylaluminum hydride solution are added. After
another hour the reaction mixture is quenched at -65.degree. C.
with a mixture of 1 M hydrochloric acid and tetrahydrofuran (1:1)
and stirred for ten minutes. Then the cooling bath is removed, the
reaction mixture is diluted with water and extracted with ethyl
acetate. The combined organic phases are dried over magnesium
sulphate and evaporated down. The crude product is purified by
chromatography over a silica gel column with cyclohexane/ethyl
acetate (2:1 to 1:1).
[0235] Yield: 9.58 g (85% of theory)
[0236] Mass spectrum (ESI.sup.+): m/z=285, 287 [M+H].sup.+
[0237] The following compounds are obtained analogously to Example
IV: [0238] (1) methyl
2-bromo-3-(3-methyl-2-buten-1-yl)-5-formyl-3H-imidazole-4-carboxylate
[0239] Mass spectrum (ESI.sup.+): m/z=301, 303 [M+H].sup.+
EXAMPLE V
dimethyl
2-bromo-3-(2-butyn-1-yl)-1H-imidazole-4,5-dicarboxylate
[0240] 4.53 ml of 1-bromo-2-butyne are added to 13.20 g dimethyl
2-bromo-1H-imidazole-4,5-dicarboxylate and 8.57 g potassium
carbonate in 70 ml N,N-dimethylformamide and the reaction mixture
is stirred overnight at ambient temperature.
[0241] For working up it is combined with water and extracted with
ethyl acetate. The combined organic phases are dried over magnesium
sulphate and evaporated down.
[0242] Yield: 14.58 g (92% of theory)
[0243] Mass spectrum (ESI.sup.+): m/z=315, 317 [M+H].sup.+
[0244] The following compounds are obtained analogously to Example
V: [0245] (1) dimethyl
2-bromo-3-(3-methyl-2-buten-1-yl)-1H-imidazole-4,5-dicarboxylate
[0246] Mass spectrum (ESI.sup.+): m/z=331, 333 [M+H].sup.+
EXAMPLE VI
Dimethyl 2-bromo-1H-imidazole-4,5-dicarboxylate
[0247] 6.11 ml bromine are added to 19.80 g dimethyl
1H-imidazole-4,5-dicarboxylate and 14.92 g potassium carbonate in
600 ml methylene chloride. The reaction mixture is stirred for one
hour at ambient temperature, then a mixture of saturated sodium
sulphite solution and saturated sodium chloride solution (1:1) is
added. The organic phase is largely separated off and the aqueous
phase is extracted with ethyl acetate several times. The combined
organic phases are dried over magnesium sulphate and evaporated
down, leaving about 7.40 g crude product. The aqueous phase is
combined with ethyl acetate and extracted overnight in an
extraction apparatus. The ethyl acetate extract is evaporated down
and the flask residue is combined with the crude product already
obtained.
[0248] Yield: 13.10 g (46% of theory)
[0249] Mass spectrum (ESI.sup.+): m/z=263, 265 [M+H].sup.+
EXAMPLE VII
2-Bromo-3-(2-butyn-1-yl)-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-on-
e
[0250] 0.50 ml of 1-bromo-2-butyne are added to 1.30 g
2-bromo-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 0.99
ml Hunig base in 30 ml of N,N-dimethylformamide. The reaction
mixture is stirred for three hours at ambient temperature. Then the
solvent is distilled off in vacuo using the rotary evaporator. The
flask residue is stirred with 40 ml of water and 0.5 ml
concentrated aqueous ammonia solution, suction filtered and washed
with ethanol as well as diethyl ether.
[0251] Yield: 1.30 g (82% of theory)
[0252] R.sub.f value: 0.60 (silica gel, cyclohexane/ethyl
acetate=3:7)
[0253] Mass spectrum (ESI.sup.+): m/z=281, 283 [M+H].sup.+
EXAMPLE VIII
2-bromo-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0254] 5.20 ml of a 1.8 M solution of bromine in acetonitrile are
slowly added dropwise to 1.40 g of
7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 1.30 g
potassium carbonate in 40 ml acetonitrile. Then the reaction
mixture is heated to 70.degree. C., whereupon the mixture is
rapidly decolourised. More bromine solution and potassium carbonate
are added batchwise until the reaction has ended, according to
HPLC-MS. For working up the reaction mixture is evaporated down,
stirred with 100 ml of water and suction filtered. The filtrate is
acidified with 1 M hydrochloric acid and extracted with ethyl
acetate. The combined extracts are dried over sodium sulphate and
evaporated down.
[0255] Yield: 1.30 g (61% of theory)
[0256] R.sub.f value: 0.37 (silica gel, methylene
chloride/methanol=9:1)
[0257] Mass spectrum (ESI.sup.+): m/z=229, 231 [M+H].sup.+
EXAMPLE IX
7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0258] A solution of 4.00 g sodium nitrite in 15 ml of water is
added dropwise at 50.degree. C. to 2.20 g of
4-amino-7-methyl-3H-imidazo[4,5-d]pyridazine in a mixture of 30 ml
acetic acid, 5 ml of water and 0.5 ml concentrated sulphuric acid.
The reaction mixture is stirred for a further two hours at
50.degree. C. and then heated to 90.degree. C. for one hour. After
cooling to ambient temperature the reaction mixture is diluted with
30 ml of water. The precipitate formed is suction filtered, washed
with water, ethanol and diethyl ether and dried.
[0259] Yield: 1.00 g (45% of theory)
[0260] Mass spectrum (ESI.sup.+): m/z=151 [M+H].sup.+
EXAMPLE X
4-amino-7-methyl-3H-imidazo[4,5-d]pyridazine
[0261] A mixture of 2.00 g 5-acetyl-3H-imidazole-4-carbonitrile and
4.00 ml hydrazine hydrate in 50 ml of ethanol is heated to
100.degree. C., until the reaction is complete according to
HPLC-MS. After cooling to ambient temperature the reaction mixture
is evaporated down, stirred with 20 ml of cold ethanol and suction
filtered. The filter cake is washed with diethyl ether and
dried.
[0262] Yield: 2.10 g (95% of theory)
[0263] Mass spectrum (ESI.sup.+): m/z=150 [M+H].sup.+
EXAMPLE XI
5-acetyl-3H-imidazole-4-carbonitrile
[0264] 57 ml of a 3 M solution of methylmagnesium bromide in
diethyl ether are added to 7.00 g of 4,5-dicyano-imidazole in 80 ml
of tetrahydrofuran under an argon atmosphere, while the temperature
is maintained between 5.degree. C. and 15.degree. C.
[0265] After two hours the reaction is complete according to thin
layer chromatography and the reaction mixture is diluted with 400
ml of ethyl acetate. Then 400 ml saturated ammonium chloride
solution are slowly added. After ten minutes the mixture is
acidified with semiconcentrated sulphuric acid and stirred for
another twenty minutes before the organic phase is separated off.
The aqueous phase is extracted with ethyl acetate and the combined
organic phases are dried over sodium sulphate and evaporated down.
The flask residue is stirred with ethyl acetate, suction filtered
and washed with ethyl acetate and diethyl ether.
[0266] Yield: 3.30 g (43% of theory)
[0267] Mass spectrum (ESI.sup.+): m/z=136 [M+H].sup.+
EXAMPLE XII
2-chloromethyl-naphtho[2,1-d]oxazole
[0268] Prepared by reacting 2.93 g of 2-amino-1-naphthol with 3.54
g of 2-chloro-1,1,1-triethoxy-ethane in 25 ml of ethanol at
60.degree. C.
[0269] Yield: 1.90 g (58% of theory)
[0270] R.sub.f value: 0.55 (silica gel, petroleum ether/ethyl
acetate=9:1)
[0271] Mass spectrum (ESI.sup.+): m/z=218, 220 [M+H].sup.+
[0272] The following compounds are obtained analogously to Example
XII: [0273] (1) 2-chloromethyl-naphtho[1,2-d]oxazole
[0274] R.sub.f value: 0.90 (silica gel, methylene
chloride/methanol=19:1)
[0275] Mass spectrum (ESI.sup.+): m/z=218, 220 [M+H].sup.+
EXAMPLE XIII
2-bromo-3-(3-methyl-2-buten-1-yl)-3,5-dihydro-imidazo[4,5-c]pyridin-4-one
[0276] 1.55 g Burgess reagent
(methoxycarbonylsulphamoyl-triethylammonium-N-betaine) are added to
1.60 g of
2-bromo-7-hydroxy-3-(3-methyl-2-buten-1-yl)-3,5,6,7-tetrahydro-imida-
zo[4,5-c]pyridin-4-one in 20 ml methylene chloride and 4 ml of
tetrahydrofuran. The reaction mixture is stirred for eight hours at
60.degree. C., then another 0.3 equivalents Burgess reagent is
added. After a further two hours the cooled reaction mixture is
combined with aqueous sodium hydrogen carbonate solution and
extracted with ethyl acetate. The combined organic phases are dried
over magnesium sulphate and evaporated down. The flask residue is
chromatographed through a silica gel column with methylene
chloride/methanol (1:0 to 10:1) as eluant.
[0277] Yield: 1.06 g (60% of theory)
[0278] Mass spectrum (ESI.sup.+): m/z=282, 284 [M+H]+
EXAMPLE XIV
2-bromo-7-hydroxy-3-(3-methyl-2-buten-1-yl)-3,5,6,7-tetrahydro-imidazo[4,5-
-c]pyridin-4-one
[0279] 90 ml of water and 5.40 g iron powder are added to 4.15 g
methyl
2-bromo-5-(1-hydroxy-2-nitro-ethyl)-3-(3-methyl-2-buten-1-yl)-3H-imidazol-
e-4-carboxylate in 270 ml of ethanol. The mixture is refluxed,
combined with 36 ml glacial acetic acid and stirred for one and a
half hours at reflux temperature. The cooled reaction solution is
filtered through Celite. The filtrate is evaporated down, combined
with ethanol and made basic with solid potassium carbonate. The
mixture is stirred for three hours at 60.degree. C. Then the
ethanol is distilled off, the flask residue is combined with water
and extracted with ethyl acetate. The combined extracts are dried
over magnesium sulphate and evaporated down. The crude product is
purified by chromatography over a silica gel column with methylene
chloride/methanol (1:1 to 7:1) as eluant.
[0280] Yield: 1.62 g (47% of theory)
[0281] Mass spectrum (ESI.sup.+): m/z=300, 302 [M+H].sup.+
EXAMPLE XV
Methyl
2-bromo-5-(1-hydroxy-2-nitro-ethyl)-3-(3-methyl-2-buten-1-yl)-3H-im-
idazole-4-carboxylate
[0282] 35 ml nitromethane are added to 1.14 g caesium carbonate in
15 ml of methanol at ambient temperature. Then the mixture is
combined with a solution of 3.50 g methyl
2-bromo-3-(3-methyl-2-buten-1-yl)-5-formyl-3H-imidazole-4-carboxylate
in 20 ml of methanol and 5 ml methylene chloride and stirred for 15
minutes at ambient temperature. Then 0.5 ml acetic acid are added
and the solution is evaporated down in vacuo. The flask residue is
combined with aqueous sodium hydrogen carbonate solution and
extracted with ethyl acetate. The combined organic phases are dried
over magnesium sulphate and evaporated down.
[0283] Yield: 4.15 g (99% of theory)
[0284] Mass spectrum (ESI.sup.+): m/z=362, 364 [M+H].sup.+
EXAMPLE XVI
2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5--
[(4-oxo-3,4-dihydro-quinazolin-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyri-
dazin-4-one
[0285] 40 mg sodium methoxide (95%) are added to a solution of 605
mg
2-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-
-cyanomethyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one in 9 ml of
methanol. The mixture is stirred for one hour at ambient
temperature and then neutralised with 41 SL glacial acetic acid.
Then a solution of 195 mg anthranilic acid in 2 ml of methanol is
added and the reaction mixture is heated to 70.degree. C. After
about two hours a white, voluminous precipitate is formed and the
reaction mixture is cooled to ambient temperature. The precipitate
formed is suction filtered, washed with cold methanol and
dried.
[0286] Yield: 234 mg (30% of theory)
[0287] Mass spectrum (ESI.sup.+): m/z=545 [M+H].sup.+
[0288] Preparation of the final compounds:
EXAMPLE 1
##STR00014##
[0289]
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]ox-
azepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
[0290] 0.33 ml trifluoroacetic acid are added to 120 mg
2-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-3-(2-butyn-1-yl)-5-[(d-
ibenzo[b,f][1,4]oxazepin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-
-4-one in 3 ml methylene chloride while cooling with an ice bath.
The reaction mixture is stirred overnight at ambient
temperature.
[0291] For working up it is poured onto cooled saturated potassium
carbonate solution and extracted with methylene chloride. The
organic phase is separated off and evaporated down. The crude
product is purified by chromatography over a silica gel column with
methylene chloride/methanol (100:0 to 70:30) as eluant.
[0292] Yield: 63 mg (63% of theory)
[0293] Mass spectrum (ESI.sup.+): m/z=494 [M+H].sup.+
[0294] The following compounds are obtained analogously to Example
1: [0295] (1)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthridin-6-yl)methyl-
]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
##STR00015##
[0296] Mass spectrum (ESI.sup.+): m/z=478 [M+H].sup.+ [0297] (2)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthren-9-yl)methyl]--
3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
##STR00016##
[0298] Mass spectrum (ESI.sup.+): m/z=477 [M+H].sup.+ [0299] (3)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(phenanthridin-6-yl)me-
thyl]-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one x
trifluoroacetic acid
##STR00017##
[0300] R.sub.f value: 0.45 (Reversed phase ready-made TLC plate (E.
Merck), acetonitrile/water/trifluoroacetic acid=50:50:0.1)
[0301] Mass spectrum (ESI.sup.+): m/z=492 [M+H].sup.+ [0302] (4)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxaz-
epin-11-yl)methyl]-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
##STR00018##
[0303] Carried out with isopropanolic hydrochloric acid (5-6 M) in
methylene chloride.
[0304] Mass spectrum (ESI.sup.+): m/z=508 [M+H].sup.+ [0305] (5)
2-((S)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxaz-
epin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
##STR00019##
[0306] Mass spectrum (ESI.sup.+): m/z=494 [M+H].sup.+ [0307] (6)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(dibenzo[b,f][1,4]oxaz-
epin-11-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
##STR00020##
[0308] Mass spectrum (ESI.sup.+): m/z=494 [M+H].sup.+ [0309] (7)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(naphtho[2,1-d]oxazol--
2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
##STR00021##
[0310] R.sub.f value: 0.40 (silica gel, methylene
chloride/ethanol/conc. aqueous ammonia=90:10:2)
[0311] Mass spectrum (ESI.sup.+): m/z=468 [M+H].sup.+ [0312] (8)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(naphtho[1,2-d]oxazol--
2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
##STR00022##
[0313] Mass spectrum (ESI.sup.+): m/z=468 [M+H].sup.+ [0314] (9)
2-((R)-3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-5-[(4-oxo-3,4-dihydro-qui-
nazolin-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one
##STR00023##
[0315] Mass spectrum (ESI.sup.+): m/z=445 [M+H].sup.+
[0316] The following compounds may also be obtained analogously to
the foregoing Examples and other methods known from the
literature:
TABLE-US-00002 No. Name Structural formula (1)
2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)-
5-[(3,4-dihydro-quinolin-2-yl)methyl]-6,7-
dimethyl-3,5-dihydro-imidazo[4,5-c]pyridin- 4-one ##STR00024## (2)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(3,4-dihydro-isoquinolin-1-yl)methyl]-7-
cyclopropyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00025##
(3) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(3,3-dimethyl-3,4-dihydro-isoquinolin-1-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00026##
(4) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(4,4-dimethyl-3,4-dihydro-isoquinolin-1-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00027##
(5) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(1-methyl-1,4-dihydro-quinazolin-2-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00028##
(6) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(1-methyl-4-oxo-1,4-dihydro-quinazolin-
2-yl)methyl]3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00029##
(7) 2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)-
5-[(5,6,7,8-tetrafluoro-1-methyl-1,4-dihydro-
quinazolin-2-yl)methyl]-3,5-dihydro- imidazo[4,5-c]pyridin-4-one
##STR00030## (8) 2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)-
5-[(3,4-dihydro-quinazolin-2-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00031## (9)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(3-methyl-3,4-dihydro-quinazolin-2-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00032##
(10) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(3-methyl-3,4-dihydro-quinazolin-2-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridin-4-one ##STR00033##
(11) 2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)-
5-[(1H-benzo[d][1,2]oxazin-4-yl)methyl]-
3,5-dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00034## (12)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(1-oxo-1H-benzo[d][1,2]oxazin-4-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00035##
(13) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(4H-benzo[e][1,3]oxazin-2-yl)methyl]-
3,5-dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00036## (14)
2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)-
5-[(4,4-dimethyl-4H-benzo[e][1,3]oxazin-2-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00037##
(15) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(4-oxo-4H-benzo[e][1,3]oxazin-2-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00038##
(16) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(4H-benzo[d][1,3]oxazin-2-yl)methyl]-
3,5-dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00039## (17)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(4H-benzo[d][1,3]oxazin-2-yl)methyl]-7-
methyl-3,5-dihydro-imidazo[4,5-c]pyridin-4- one ##STR00040## (19)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(4,4-dimethyl-4H-benzo[d][1,3]oxazin-2-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00041##
(20) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(4-oxo-4H-benzo[d][1,3]oxazin-2-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00042##
(21) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2H-benzo[1,4]oxazin-3-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00043## (22)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2-oxo-2H-benzo[1,4]oxazin-3-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00044##
(23) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2,2-dimethyl-2H-benzo[1,4]oxazin-3-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00045##
(24) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[4H-benzo[e][1,3]thiazin-2-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00046## (25)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[4,4-dimethyl-4H-benzo[e][1,3]thiazin-2-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00047##
(26) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[4-oxo-4H-benzo[e][1,3]thiazin-2-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00048##
(27) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(4H-benzo[d][1,3]thiazin-2-yl)methyl]-
3,5-dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00049## (28)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2H-benzo[1,4]thiazin-3-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00050## (29)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2-oxo-2H-benzo[e][1,3]oxazin-4-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00051##
(30) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(1-methyl-2,2-dioxo-1H- benzo[c][1,2]thiazin-4-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00052## (31)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2,3-dihydro-1H-benzo[e][1,4]diazepin-5-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00053##
(32) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2-oxo-2,3-dihydro-1H- benzo[e][1,4]diazepin-5-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00054## (33)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(1-methyl-2,3-dihydro-1H-
benzo[e][1,4]diazepin-5-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00055## (34)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(1-methyl-2-oxo-2,3-dihydro-1H-
benzo[e][1,4]diazepin-5-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00056## (35)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(4-oxo-4,5-dihydro-3H- benzo[b][1,4]diazepin-2-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00057## (36)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(5-methyl-4-oxo-4,5-dihydro-3H-
benzo[b][1,4]diazepin-2-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00058## (37)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[5-oxo-4,5-dihydro-3H- benzo[e][1,4]diazepin-2-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00059## (38)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[4-methyl-5-oxo-4,5-dihydro-3H-
benzo[3][1,4]diazepin-2-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00060## (39)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2,3-dihydro-benzo[f][1,4]oxazepin-5-
yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00061##
(40) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(3,3-dimethyl-2,3-dihydro-
benzo[f][1,4]oxazepin-5-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00062## (41)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2,2-dimethyl-2,3-dihydro- benzo[f][1,4]oxazepin-5-yl)methyl]-7-
methyl-3,5-dihydro-imidazo[4,5-d]pyridazin- 4-one ##STR00063## (42)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2,3-dihydro-benzo[b][1,4]oxazepin-4-
yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one
##STR00064## (43) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(6,6-dimethyl-2,3-dihydro- benzo[b][1,4]oxazepin-4-yl)methyl]-7-
methyl-3,5-dihydro-imidazo[4,5-d]pyridazin- 4-one ##STR00065## (44)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2,3-dihydro-benzo[b][1,4]thiazepin-4-
yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one
##STR00066## (45) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2,2-dimethyl-2,3-dihydro-
benzo[b][1,4]thiazepin-4-yl)methyl]-7-
methyl-3,5-dihydro-imidazo[4,5-d]pyridazin- 4-one ##STR00067## (46)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2,3-dihydro-benzo[f][1,4]thiazepin-5-
yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one
##STR00068## (47) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(5-oxo-4,5-dihydro- benzo[f][1,3,4]oxadiazepin-2-yl)methyl]-7-
methyl-3,5-dihydro-imidazo[4,5-d]pyridazin- 4-one ##STR00069## (48)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(11H-dibenzo[b,e]azepin-6-yl)methyl]-7-
ethyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4- one ##STR00070## (49)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(11H-dibenzo[b,e]azepin-6-yl)methyl]-7-
cyanomethyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00071##
(50) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(11,11-difluoro-11H-dibenzo[b,e]azepin-
6-yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one ##STR00072##
(51) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(11-oxo-11H-dibenzo[b,e]azepin-6-
yl)methyl]-7-(2-cyanoethyl)-3,5-dihydro-
imidazo[4,5-d]pyridazin-4-one ##STR00073## (52)
2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)-
5-[(11H-benzo[e]pyrido[3,2-b]azepin-6-
yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one
##STR00074## (53) 2-(3-amino-piperidin-1-yl-(2-butyn-1-yl)-5-
[(5H-1,9,10-triaza-dibenzo[a,d]cyclohepten-
11-yl)methyl]-3,5-dihydro-imidazo[4,5- d]pyridin-4-one ##STR00075##
(54) 2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)-
5-[(5-methyl-5H-dibenzo[b,e][1,4]diazepin-
11-yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one
##STR00076## (55) 2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)-
5-[(dibenzo[b,f][1,4]oxazepin-11-yl)methyl]-
3,5-dihydro-imidazo[4,5-c]pyridin-4-one ##STR00077## (56)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(dibenzo[b,f][1,4]thiazepin-11-yl)methyl]-
7-methyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00078##
(57) 2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)-
5-[(dibenzo[b,f][1,4]thiazepin-11-yl)methyl]-
3,5-dihydro-imidazo[4,5-c]pyridin-4-one ##STR00079## (58)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(5-oxo-dibenzo[b,f][1,4]thiazepin-11-
yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one
##STR00080## (59) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(5,5-dioxo-dibenzo[b,f][1,4]-thiazepin-11-
yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one
##STR00081## (60) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(5H-dibenzo[a,d]cyclohepten-10- yl)methyl]-7-methyl-3,5-dihydro-
imidazo[4,5-d]pyridazin-4-one ##STR00082## (61)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(5-methyl-5H-dibenzo[b,f]azepin-10-
yl)methyl]-7-trifluoromethyl-3,5-dihydro-
imidazo[4,5-d]pyridazin-4-one
##STR00083## (62) 2-(3-amino-piperidin-1-yl)-3-(3-methyl-2-
buten-1-yl)-5-[(phenanthridin-6-yl)methyl]-
7-methyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one ##STR00084##
(63) 2-(3-amino-piperidin-1-yl)-3-(2-buten-1-yl)-
5-[(phenanthridin-6-yl)methyl]-7-methyl-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00085## (64)
2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)-
5-[(phenanthridin-6-yl)methyl]-7-methyl-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00086## (65)
2-(3-amino-piperidin-1-yl)-3-[(1-
cyclopenten-1-yl)methyl]-5-[(phenanthridin-
6-yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one
##STR00087## (66) 2-(3-amino-piperidin-1-yl)-3-(1-buten-1-yl)-
5-[(phenanthridin-6-yl)methyl]-3,5-dihydro-
imidazo[4,5-c]pyridin-4-one ##STR00088## (67)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(benzo[c][1,5]naphthyridin-6-yl)methyl]-
7-cyclopropyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one
##STR00089## (68) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(benzo[h][1,6]naphthyridin-5-yl)methyl]-
3,5-dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00090## (69)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(benzo[c][1,8]naphthyridin-6-yl)methyl]-
3,5-dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00091## (70)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(5-benzo[f][1,7]naphthyridin-5-
yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one ##STR00092##
(71) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(1,5,9-triaza-phenanthren-10-yl)methyl]-
3,5-dihydro-imidazo[4,5-c]pyridin-4-one ##STR00093## (72)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(1,2,3,4-tetrahydrophenanthridin-6-
yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one ##STR00094##
(73) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(1,2,3,4,4a,10b-hexahydro-phenanthridin-
6-yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one ##STR00095##
(74) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2,3-dihydro-1H-4-aza- cyclopenta[a]naphth-5-yl)methyl]-3,5-
dihydro-imidazo[4,5-c]pyridin-4-one ##STR00096## (75)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(8,9,10,11-tetrahydro-7H-6-aza-
cyclohepta[a]naphth-5-yl)methyl]-3,5-
dihydro-imidazo[4,5-c]pyridin-4-one ##STR00097## (76)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2,3-dihydro-1H-4-oxo-10-aza-
phenanthren-9-yl)methyl]-3,5-dihydro- imidazo[4,5-c]pyridin-4-one
##STR00098## (77) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(1-oxo-2,3-dihydro-1H-4-oxo-10-aza-
phenanthren-9-yl)methyl]-3,5-dihydro- imidazo[4,5-c]pyridin-4-one
##STR00099## (78) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(10-cyanophenanthren-9-yl)methyl]-3,5-
dihydro-imidazo[4,5-c]pyridin-4-one ##STR00100## (79)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(benzo[h]quinolin-6-yl)methyl]-3,5-
dihydro-imidazo[4,5-c]pyridin-4-one ##STR00101## (80)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(benzo[f]quinolin-6-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00102## (81)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(benzo[f]quinoxalin-6-)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00103## (82)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-
11-yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one
##STR00104## (83) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(thieno[3,2-b][1,4]benzoxazepin-9-
yl)methyl]-7-trifluoromethyl-3,5-dihydro-
imidazo[4,5-d]pyridazin-4-one ##STR00105## (84)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(thieno[3,2-b][1,4]benzoxazepin-9-
yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one ##STR00106##
(85) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(5H-dibenzo[d,f][1,3]diazepin-6-
yl)methyl]-7-methyl-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one
##STR00107## (86) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(5-methyl-5H-dibenzo[d,f][1,3]diazepin-
6-yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one ##STR00108##
(87) 2-(3-amino-piperidin-1-yl)-3-(3-methylbut-2-
en-1-yl)-5-[(5-oxa-7-aza- dibenzo[a,c]cyclohepten-6-yl)methyl]-7-
methyl-3,5-dihydro-imidazo[4,5-c]pyridin-4- one ##STR00109## (88)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(naphtho[1,2-d]thiazol-2-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00110## (89)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(naphtho[2,1-d]thiazol-2-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00111## (90)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(3H-naphtho[1,2-d]imidazol-2-yl)methyl]-
3,5-dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00112## (91)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(naphtho[1,2-b]furan-2-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00113## (92)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(naphtho[2,1-b]furan-2-yl)methyl]-3,5-
dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00114## (93)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(2-methyl-furo[3,2-c]isoquinolin-5-
yl)methyl]-3,5-dihydro-imidazo[4,5- c]pyridin-4-one ##STR00115##
(94) 2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(pyrazolo[1,5-c]quinazolin-5-yl)methyl]-
3,5-dihydro-imidazo[4,5-d]pyridazin-4-one ##STR00116## (95)
2-(3-amino-piperidin-1-yl)-3-(2-butyn-1-yl)-
5-[(1H-perimidin-2-yl)methyl]-3,5-dihydro-
imidazo[4,5-d]pyridazin-4-one ##STR00117##
EXAMPLE 2
Coated Tablets Containing 75 mg of Active Substance
TABLE-US-00003 [0317] 1 tablet core contains: active substance 75.0
mg calcium phosphate 93.0 mg corn starch 35.5 mg
polyvinylpyrrolidone 10.0 mg hydroxypropylmethylcellulose 15.0 mg
magnesium stearate 1.5 mg 230.0 mg
Preparation:
[0318] The active substance is mixed with calcium phosphate, corn
starch, polyvinylpyrrolidone, hydroxypropylmethylcellulose and half
the specified amount of magnesium stearate. Blanks 13 mm in
diameter are produced in a tablet-making machine and these are then
rubbed through a screen with a mesh size of 1.5 mm using a suitable
machine and mixed with the rest of the magnesium stearate. This
granulate is compressed in a tablet-making machine to form tablets
of the desired shape. [0319] Weight of core: 230 mg [0320] die: 9
mm, convex
[0321] The tablet cores thus produced are coated with a film
consisting essentially of hydroxypropylmethylcellulose. The
finished film-coated tablets are polished with beeswax. [0322]
Weight of coated tablet: 245 mg.
EXAMPLE 3
Tablets containing 100 mg of active substance
TABLE-US-00004 [0323] Composition: 1 tablet contains: active
substance 100.0 mg lactose 80.0 mg corn starch 34.0 mg
polyvinylpyrrolidone 4.0 mg magnesium stearate 2.0 mg 220.0 mg
Method of Preparation:
[0324] The active substance, lactose and starch are mixed together
and uniformly moistened with an aqueous solution of the
polyvinylpyrrolidone. After the moist composition has been screened
(2.0 mm mesh size) and dried in a rack-type drier at 50.degree. C.
it is screened again (1.5 mm mesh size) and the lubricant is added.
The finished mixture is compressed to form tablets. [0325] Weight
of tablet: 220 mg [0326] Diameter: 10 mm, biplanar, facetted on
both sides and notched on one side.
EXAMPLE 4
Tablets Containing 150 mg of Active Substance
TABLE-US-00005 [0327] Composition: 1 tablet contains: active
substance 150.0 mg powdered lactose 89.0 mg corn starch 40.0 mg
colloidal silica 10.0 mg polyvinylpyrrolidone 10.0 mg magnesium
stearate 1.0 mg 300.0 mg
Preparation:
[0328] The active substance mixed with lactose, corn starch and
silica is moistened with a 20% aqueous polyvinylpyrrolidone
solution and passed through a screen with a mesh size of 1.5 mm.
The granules, dried at 45.degree. C., are passed through the same
screen again and mixed with the specified amount of magnesium
stearate. Tablets are pressed from the mixture. [0329] Weight of
tablet: 300 mg [0330] die: 10 mm, flat
EXAMPLE 5
Hard Gelatine Capsules Containing 150 mg of Active Substance
TABLE-US-00006 [0331] 1 capsule contains: active substance 150.0 mg
corn starch (dried) approx. 80.0 mg lactose (powdered) approx. 87.0
mg magnesium stearate 3.0 mg approx. 420.0 mg
Preparation:
[0332] The active substance is mixed with the excipients, passed
through a screen with a mesh size of 0.75 mm and homogeneously
mixed using a suitable apparatus. The finished mixture is packed
into size 1 hard gelatine capsules. [0333] Capsule filling: approx.
320 mg [0334] Capsule shell: size 1 hard gelatine capsule.
EXAMPLE 6
Suppositories Containing 150 mg of Active Substance
TABLE-US-00007 [0335] 1 suppository contains: active substance
150.0 mg polyethyleneglycol 1500 550.0 mg polyethyleneglycol 6000
460.0 mg polyoxyethylene sorbitan monostearate 840.0 mg 2,000.0
mg.sup.
Preparation:
[0336] After the suppository mass has been melted the active
substance is homogeneously distributed therein and the melt is
poured into chilled moulds.
EXAMPLE 7
Suspension Containing 50 mg of Active Substance
TABLE-US-00008 [0337] 100 ml of suspension contain: active
substance 1.00 g carboxymethylcellulose-Na-salt 0.10 g methyl
p-hydroxybenzoate 0.05 g propyl p-hydroxybenzoate 0.01 g glucose
10.00 g glycerol 5.00 g 70% sorbitol solution 20.00 g flavouring
0.30 g dist. water ad 100 ml
Preparation:
[0338] The distilled water is heated to 70.degree. C. The methyl
and propyl p-hydroxybenzoates together with the glycerol and sodium
salt of carboxymethylcellulose are dissolved therein with stirring.
The solution is cooled to ambient temperature and the active
substance is added and homogeneously dispersed therein with
stirring. After the sugar, the sorbitol solution and the flavouring
have been added and dissolved, the suspension is evacuated with
stirring to eliminate air. [0339] 5 ml of suspension contain 50 mg
of active substance.
EXAMPLE 8
Ampoules Containing 10 mg Active Substance
TABLE-US-00009 [0340] Composition: active substance 10.0 mg 0.01 N
hydrochloric acid q.s. double-distilled water ad 2.0 ml
Preparation:
[0341] The active substance is dissolved in the necessary amount of
0.01 N HCl, made isotonic with common salt, filtered sterile and
transferred into 2 ml ampoules.
EXAMPLE 9
Ampoules Containing 50 mg of Active Substance
TABLE-US-00010 [0342] Composition: active substance 50.0 mg 0.01 N
hydrochloric acid q.s. double-distilled water ad 10.0 ml
Preparation:
[0343] The active substance is dissolved in the necessary amount of
0.01 N HCl, made isotonic with common salt, filtered sterile and
transferred into 10 ml ampoules.
* * * * *