U.S. patent application number 12/433571 was filed with the patent office on 2009-08-27 for gel-based cosmetic and wound-healing formulation and method.
Invention is credited to Ronald DiSalvo, Barry Knapp.
Application Number | 20090214501 12/433571 |
Document ID | / |
Family ID | 32328897 |
Filed Date | 2009-08-27 |
United States Patent
Application |
20090214501 |
Kind Code |
A1 |
Knapp; Barry ; et
al. |
August 27, 2009 |
GEL-BASED COSMETIC AND WOUND-HEALING FORMULATION AND METHOD
Abstract
Disclosed are gel-based cosmetic and wound-healing formulations,
methods for making said formulations, and a method for
simultaneously treating and concealing injuries to human skin. In
one exemplary embodiment, the cosmetic and wound-healing
formulation comprises live yeast cell extract, pigment, and a
gel.
Inventors: |
Knapp; Barry; (Irvine,
CA) ; DiSalvo; Ronald; (Marina Del Rey, CA) |
Correspondence
Address: |
Zarian Midgley & Johnson PLLC
University Plaza, 960 Broadway Ave., Suite 250
Boise
ID
83706
US
|
Family ID: |
32328897 |
Appl. No.: |
12/433571 |
Filed: |
April 30, 2009 |
Related U.S. Patent Documents
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Application
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Filing Date |
Patent Number |
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11551501 |
Oct 20, 2006 |
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12433571 |
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10440990 |
May 19, 2003 |
7217417 |
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11551501 |
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60382034 |
May 20, 2002 |
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Current U.S.
Class: |
424/93.51 |
Current CPC
Class: |
A61K 31/01 20130101;
A61K 33/24 20130101; A61K 36/064 20130101; A61K 33/26 20130101;
Y10S 514/844 20130101; A61K 31/80 20130101; Y10S 514/944 20130101;
A61L 26/0057 20130101; A61L 26/008 20130101; A61K 31/01 20130101;
A61K 2300/00 20130101; A61K 31/80 20130101; A61K 2300/00 20130101;
A61K 33/24 20130101; A61K 2300/00 20130101; A61K 33/26 20130101;
A61K 2300/00 20130101; A61K 36/064 20130101; A61K 2300/00
20130101 |
Class at
Publication: |
424/93.51 |
International
Class: |
A61K 35/66 20060101
A61K035/66 |
Claims
1. A gel-based formulation for topical application comprising: live
yeast cell extract comprising about 0.5% to about 2% by weight of
said gel-based formulation; isododecane comprising about 8% to
about 12% by weight of said gel-based formulation;
silicon-containing compound comprising about 1.5% to about 2% by
weight of said gel-based formulation; and metal-based pigment.
2. The gel-based formulation of claim 1, wherein the live yeast
cell extract and the pigment are suspended in the gel.
3. The gel-based formulation of claim 1, wherein the gel comprises:
ethylene/propylene/styrene copolymer; and/or
ethylene/butylene/styrene copolymer.
4. The gel-based formulation of claim 1, wherein the
silicon-containing compound comprises silica dimethyl silyate.
5. The gel-based formulation of claim 1, wherein the
silicon-containing compound comprises a silicone-grafted
copolymer.
6. The gel-based formulation of claim 1, wherein the
silicon-containing compound comprises a silicone gelling agent.
7. The gel-based formulation of claim 1, wherein the metal-based
pigment comprises one or more pigments selected from the following:
titanium dioxide methicone, yellow iron oxide, red iron oxide, and
black iron oxide.
8. A method of simultaneously healing and disguising wounds on
human skin, comprising topically applying the gel-based formulation
of claim 1 to the skin.
9. A method of preparing a formulation for topical application
comprising: homogenizing a gel in a cold process; and assimilating
a live yeast cell extract and a pigment into the gel during the
homogenizing of the gel.
10. The method of claim 9, wherein isododecane is pre-mixed in a
homogenizer with: ethylene/propylene/styrene copolymer; and/or
ethylene/butylene/styrene copolymer.
11. A method of preparing a formulation for topical application
comprising: creating a gel using a roller mill; and assimilating a
live yeast cell extract and a pigment into the gel during the
creation of the gel.
12. The method of claim 12, wherein isododecane is pre-mixed in a
homogenizer with: ethylene/propylene/styrene copolymer; and/or
ethylene/butylene/styrene copolymer.
Description
BACKGROUND OF THE INVENTION
[0001] 1. Field of the Invention
[0002] The present invention relates to compositions applied to the
skin for cosmetic and healing purposes.
[0003] 2. Description of the Related Art
[0004] Both cosmetic creams and healing creams are well known. Both
of these types of topically applied compositions are frequently
made with a petroleum base to deliver pigments and healing factors
to the skin.
[0005] Cosmetic creams typically include a hydrocarbon base in
combination with pigments. Occlusive natural oils and synthetic
long-chain hydrocarbons have been used in construction of modern
makeup or foundation bases. Such oils and hydrocarbons impart
sheen, function as binders for the waxy components in the formula,
and form the bases of the oil phase of conventional emulsion
systems.
[0006] Physicians often prescribe to patients wound-healing creams
to expedite healing of wounds and the surrounding skin. Live yeast
cell extract (LYCE), Aloe Vera, colostrum and Vitamin E are
examples of common healing factors, LYCE, which has been variously
called Biodynes, Skin Respiratory Factors, and Tissue Respiratory
Factors, can be harvested from the nucleus of saccharmoyces
cerevisiae cells after the yeast has been cultured in an
appropriate nutritional media and then stressed by heat, or by UV
radiation (.about.286 nm), x-rays or chemical injury. Irradiation
and especially elevated temperatures produce heat stress, or
heat-shock proteins, in all cells (Demple, B. 1998. Signal
transduction: a bridge to control. Science 279(5357) 1655).
Elevated temperature causes cellular proteins to lose their
three-dimensional structure, and heat stress proteins are capable
of restoring the original configuration. If the cell is then
removed and its protoplasm concentrated, LYCE may be obtained. LYCE
can be prepared as an alcohol extract of viable Saccharomyces
Lysate. LYCE stimulates wound oxygen consumption, epitheliazation,
and collagen synthesis. In topical medicinal preparations, LYCE is
characterized and quantified in terms of Skin Respiratory Factor
(SRF) units. A unit of activity is calculated as the amount of SRF
which is required to increase the oxygen uptake of 1 mg of dry
weight rat abdominal skin by 1 percent at the end of a 1 hour
testing period in a Warburg apparatus.
[0007] LYCE-biofactors harvested from saccharmoyces cerevisiae
contain nutrients such as peptides, proteins, amino acids, minerals
carbohydrates, nucleic acid and other gene products. After
processing, LYCE-biofactors are clear and sediment-free, retaining
the active components without the dark color or odor of the
starting material (Fishman, H. M. 2001. Yeast Has Applications In
The Cosmetics Industry, HAPPI, July, 42). LYCE biofactors may
induce a respiratory response in viable cells, as measured by
Warburg Assay, by spectrophotometric absorbance, or by oxygen
electrode measurement of cultured human fibroblasts (Lods, L., D.
Scholz, C. Dres, C. Johnson & G. Brooks. 2000.
Peroxide-Inducible Protective Factors Produced by Saccharomyces
cerevisiae. Cosmet & Toil 115(12) 61-6. Fishman, H. M. 2001.
Yeast Has Applications In The Cosmetics Industry, HAPPI, July, 42).
Further, when delivered to the lower strata of the skin, LYCE
biofactors stimulate oxygen consumption by viable cells, causing
cellular proliferation and collagen and elastin synthesis.
[0008] Temporary cosmetic side effects, such as swelling, bruising,
or visible scars, commonly result from plastic surgery or other
injuries to skin. It may take days, weeks, or even months before
wounds heal and such side effects disappear. Historically, healing
creams and cosmetic creams have been used independently to heal and
disguise skin wounds.
SUMMARY OF THE INVENTION
[0009] The present invention relates to a gel-based formulation
containing pigments and wound-healing agents, which simultaneously
aids in healing skin wounds and concealing damage to the skin.
[0010] One aspect of the invention includes a gel-based
formulation, including: live yeast cell extract, isododecane,
silicon-containing compounds, and metal-based pigment. In one
preferred embodiment of the formulation, the live yeast cell
extract and pigment are suspended in the gel. The pigments in the
formulation are preferably titanium dioxide and iron oxide. Silica,
silicone-grafted copolymers, and silicone gelling agents are the
preferred silicone-containing compounds in the formulation. The gel
preferably contains a combination of ethylene, butylene, propylene,
and styrene.
[0011] Another aspect of the invention includes a method of
topically applying a gel-based formulation to simultaneously heal
and disguise wounds on human skin.
[0012] Another aspect of the invention includes a method of
preparing a formulation for topical application. One preferred
method involves homogenizing a gel in a cold process and
assimilating a live yeast cell extract and a pigment into the gel
during the homogenizing of the gel. The isododecane may be
pre-mixed with ethylene, propylene, styrene, and butylene in a
homogenizer. Another preferred embodiment involves creating a gel
using a roller mill and assimilating a live yeast cell extract and
a pigment into the gel during the creation of the gel.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
[0013] One embodiment of the present invention comprises a
gel-based formulation that can be applied topically to the skin.
Pigments and LYCE can be suspended within the gel-based
formulation. The LYCE can be present in an aqueous state and
surrounded by two or more membrane layers of pigmented gel. In one
preferred embodiment, the gel contains isododecane,
silicon-containing compounds, ethylene/propylene/styrene and
ethylene/butylene/styrene based copolymers. Gel, as opposed to
petroleum, facilitates oxygenation of the skin and does not clog
pores in skin. Thus, the gel-based formulation is particularly
well-suited for use on open wounds. For example, the formulation
can be used to promote healing and to conceal swelling, bruising,
or visible scars associated with wounds. The formulation is
particularly well-suited for use during the recovery phase
following a surgical procedure.
[0014] In one preferred embodiment, isododecane serves as the
primary non-water liquid and solvent for the formation of a unique
gel base which, in combination with other moieties, forms a linear
polymer meshwork. Isododecane may be combined with other heavier
emollients to give a balanced, relatively dry and non-tacky
feel.
[0015] The gellants themselves are preferably combinations of an
ethylene/propylene/styrene copolymer and a
butylene/ethylene/styrene copolymer. The ethylene/propylene and
butylene/ethylene segments of these copolymers dissolve in the
hydrocarbon or ester material, while the styrene portions do not.
The insoluble styrene blocks naturally associate with each other
via intermolecular forces and become the building blocks for a
microscopic three-dimensional network with molecules of ester,
occlusive oils, or other volatile oils enclosed therein.
[0016] The microscopically intertwined polymeric and ester, or oil
molecules, provide a stable foundation for fine particles to be
incorporated into the system and to stay suspended. For example,
pigments may be incorporated into the formulation and suspended in
the gel. Exemplary pigments include, but are not limited to,
titanium dioxide, iron oxide, or the like. Because the fine
particles are enclosed in the polymeric network, agglomeration is
minimized and a stable particle suspension results. The polymers
that are dissolved in the isododecane also form a continuous film
when applied onto the keratin substrate. The volatile isododecane
ester replaces the non-volatile oils found in conventional cosmetic
foundations. The ester delivers the polymer and other suspended
colorants to the substrate, then evaporates off and forms a matrix
on the skin. This matrix is advantageously both water-resistant and
rub-off resistant, but is nevertheless gas permeable.
[0017] Silicon-containing compounds are preferably included in the
formulation and aid in forming the emulsion, improving the texture,
and delivering the active ingredients of the formulation. In one
preferred embodiment, a silicone-grafted copolymer may consist of a
principal chain composed of an acrylic polymer and a side chain
composed of dimethyl polysiloxane. Such a compound has film-forming
properties similar to acrylic polymers along with the lubricity,
gas permeability, water-repellency and mold-releasing properties of
silicones, which enables the formation of a soft, water-repellent
film that affords additional skin protection and further aids in
the dispersion of the inorganic powder components of the
formula.
[0018] In another preferred embodiment, silica can be included in
the formulation. Silica can serve as a slip modifier, a moisture
barrier, a suspending agent, and an anti-caking agent. In
particular, silica dimethyl silyate can be preferably included in
the formulation.
[0019] In another preferred embodiment, silicone gelling agents
improve the stability of other silicone components by means of
their film-forming properties, lubricity, gas permeability,
water-repellency and mold-releasing properties. Silicone gelling
agents additionally increase the hydrophilicty of silicones.
Hydrophilic groups are preferably added by introducing
polyoxyethylene chains to the polymerization mix. While silicone
gelling agents containing hydrophilic groups that are cross-linked
can be obtained by adding methyl hydrogen polysiloxane to the
polyoxyethylene diallylether in order to gel silicone "oils," they
do not allow for the incorporation of other oil-phase materials
such as liquid paraffin or ester "oils." To achieve incorporation
of other oil-phase materials, some of the methyl groups on the
polysiloxane backbone can be preferably replaced with long alkyl
chains. Another alternative to achieve incorporation of other
oil-phase materials is to react the modified polysiloxane with
additional polyoxyethylene diallylether. Both of these methods
achieve the desired gelling of non-silicone oils and hydrophilicity
of a stable water-in-silicone emulsion in the formation.
[0020] The hybrid silicone gelling agents not only gelatinize
silicones and other "oils" with low viscosity but also, by
absorbing large amounts of water into the gel (Nomura, T. &
Yokkoji, K., Skuta, K. 1999a. J Soc Cosmet Chem Japan 33(2)
134-39), preferably form stable emulsions when the water phase is
added to further enhance physical spreadability onto the substrate
(Nomura, T. & Yokkoji, 1999b. Material Technology 17(8)
329-32). At the same time, the hybrid silicone gelling agents
ensure suspension of pigment and other inorganic materials in the
second skin matrix (Ono, I. 2001, Development of New Cosmetic
Silicones for Foundation Formulations. Cosmet & Toil 116(3)
61-6), and deliver water-soluble active ingredients such as LYCE to
the keratin substrate.
[0021] As discussed above, the gel-based formulation may include
isododecane, live yeast cell extract, silicon-containing compounds,
and pigment. In one preferred embodiment, the formulation includes:
about 0.1-15 wt. % isododecane; about 0.15-20 wt. % LYCE; about
0.1-3 wt. % silica; and about 3-12 wt. % pigment.
[0022] In preferred embodiments, the formulation can contain a
variety of preservatives, solvents, binding agents, emulsion
stabilizers, film formers, anti-caking agents, moisturizers, and
other ingredients commonly used in cosmetic and healing creams.
[0023] One exemplary formulation may comprise about 55-57 wt. %
water, about 13-14 wt. % isododecane, about 6-7 wt. % titanium
dioxide, about 4-5 wt. % cyclopentasiloxane, about 2-3 wt. %
butylene glycol, about 2 wt. % dioctyldodecyl dodecaneodioate,
about 2 wt. % silica dimethyl silylate, about 1-1.5 wt. %
polyglyceryl-4 isostearate, about 1-1.5 wt. % cetyl dimethicone
copolyol, about 1-1.5 wt. % hexyl laurate, about 1-1.5 wt. %
cyclomethicone, about 1 wt. % nylon-12, about 1 wt. % sodium
chloride, about 0.7 wt. % saccharomyces lysate extract, about 0.7
wt. % phenoxyethanol, about 0.6 wt. % ethylene mixed copolymer,
about 0.5 wt. % PEG/PPG-20/15 dimethicone, about 0.2-0.3 wt. %
quaternium-18 hectorite, about 0.25 wt. % yellow iron oxide, about
0.25 wt. % red iron oxide, about 0.25 wt. % black iron oxide, about
0.1-0.2 wt. % methicone, about 0.1-0.2 wt. % methylparaben, about
0.05-0.10 wt. % butylparaben, about 0.05-0.10 wt. % SDA alcohol 40,
about 0.05 wt. % ethylparaben, and about 0.05 wt. % propylparaben.
The ingredients in the formulation may be separate, or they may be
pre-combined. For example, the isododecane and ethylene mixed
copolymer may be added separately, or some isododecane may be
pre-mixed with some or all of the copolymer. Similarly, materials
such as methicone may be added to the formulation in combination
with other components of the formulation, such as pigments.
[0024] In one preferred embodiment, the formulation is prepared by
homogenizing a gel in a cold process. Live yeast cell extract and
pigments are preferably assimilated into the gel during the
homogenizing process. In one preferred embodiment, isododecane is
pre-mixed in a homogenizer with ethylene/propylene/styrene
copolymer and/or ethylene/butylene/styrene copolymer. In another
preferred embodiment, a roller mill can be used in place of a
homogenizer.
[0025] One method of preparing the exemplary formulation described
above preferably involves homogenizing the base gel composition
through a cold process while assimilating the LYCE and pigments.
More specifically, the method involves first pre-mixing isododecane
with ethylene mixed copolymer in the main tank of a homogenizer.
Then cyclopentasiloxane and PEG/PPG-20/15 dimethicone are added and
the composition is mixed. Then polyglyceryl-4 isostearate, cetyl
dimethicone copolyol and hexyl laurate are added, and the
composition is mixed. Then cyclomethicone, quaternium-18 hectorite
and SDA alcohol 40 are added, and the composition is mixed. Then
dioctyldodecyl dodecaneodioate is added, and the composition is
mixed. After this addition, the composition is mixed for about 15
additional minutes. In a separate vessel, nylon-12, titanium
dioxide methicone, yellow iron oxide, red iron oxide, black iron
oxide, and silica dimethyl silylate are pre-blended. This mixture
is then added to the main tank of the homogenizer, which is set to
prop mixing. The new mixture is then blended for about 45 minutes.
In a separate vessel, water and saccharomyces lysate extract are
blended until homogeneous. Then butylene glycol is added and the
mixture is blended until homogeneous. Then phenoxyethanol,
methylparaben, ethylparaben, propylparaben and butylparaben are
added, and the mixture is blended until homogeneous. Then sodium
chloride is added and the mixture is blended until homogeneous.
Finally, this separate mixture is added to the main vessel of the
homogenizer, and the whole mixture is blended for about 15
additional minutes. This exemplary method of preparation using
commercially available chemical products is summarized in Table I.
In an alternative preferred embodiment, a roller mill, rather than
homogenization through a cold process, can be used to create the
formulation.
EXAMPLES
[0026] As an example, in one embodiment, a formulation comprises
57.550 wt. % water, 13.300 wt. % isododecane, 6.860 wt. % titanium
dioxide, 4.500 wt. % cyclopentasiloxane, 2.500 wt. % butylene
glycol, 2.000 wt. % dioctyldodecyl dodecaneodioate, 2.000 wt. %
silica dimethyl silylate, 1.365 wt. % polyglyceryl-4 isostearate,
1.365 wt. % cetyl dimethicone copolyol, 1.365 wt. % hexyl laurate,
1.155 wt. % cyclomethicone, 1.000 wt. % nylon-12, 1.000 wt. %
sodium chloride, 0.700 wt. % saccharomyces lysate extract, 0.700
wt. % phenoxyethanol, 0.600 wt. % ethylene mixed copolymer, 0.500
wt. % PEG/PPG-20/15 dimethicone, 0.270 wt. % quaternium-18
hectorite, 0.245 wt. % yellow iron oxide, 0.245 wt. % red iron
oxide, 0.245 wt. % black iron oxide, 0.160 wt. % methicone, 0.110
wt. % methylparaben, 0.090 wt. % butylparaben, 0.075 wt. % SDA
alcohol 40, 0.050 wt. % ethylparaben, 0.050 wt. %
propylparaben.
[0027] Those of ordinary skill in the art will appreciate that the
element amounts listed above are exemplary only, and that the
amount of any element or group of elements in the formulation can
be varied within acceptable ranges that are known in the art. In
addition, those of ordinary skill in the art will appreciate that
other elements may be substituted for the elements listed above or
that other elements may be added to the formulation. For example,
in the formulation described above, the elements comprising the
pigment constitute about 8 wt. % of the formulation. In other
embodiments, the elements comprising the pigment may constitute a
greater or lesser wt. % of the formulation. For example, in one
embodiment, the elements comprising the pigment constitute about 12
wt. % of the formulation.
[0028] In another exemplary preferred embodiment, the formulation
can be made as a mixture of commercially available chemical
products, as summarized in Table 1.
TABLE-US-00001 TABLE I GEL-BASE MAKE-UP w/ LYCE Ingredient Name
Mfr./Vendor US INCI (EO INCI) Name % WW A FANCOL ID Fanning/DD
Chemco Isododecane 10.00 GEL BASE 1 Arch Personal Care Isododecane
(and) Ethylene Mixed 4.00 Copolymer SF 1528 GE/DD Chemco
Cyclopentasiloxane (and) PEG/PPG- 5.00 20/15 Dimethicone A_L WE-09
Goldschmidt/Ross Org Polyglycervl-4 Isostearate (and) Cetyl 4.00
Dimethicone (Copolyel (and) Hexyl Laurate BENTONE GEL VS-5
Elementis Cyclomethicone (and) Quaternium-18 1.50 Hectorite (and)
SDA Alcohol 40 LIQUIWAX DIADD Arch Personal Care Diocetyldodecyl
Dodecaneodiate 2.00 B ORGASOL 2002 EX Lipo/DD Chemco Nylon-12 1.00
DN AT TIO-SI Cardre Titanium Dioxide (and) Methicone 7.00 YELLOW
IRON Cardre Iron Oxide (and) Methicone 0.25 OXIDE S12 RED IRON
OXIDE Cardre Iron Oxide (and) Methicone 0.25 S12 BLACK IRON Cadre
Iron Oxide (and) Methicone 0.25 OXIDE S12 WACKER HDK H20
Wacker-Chemic Silca Dimethyl Silylate 2.00 C DI WATER Water (Aqua)
55.45 BIODYNES TRF Arch Personal Care Water (and) Saccharomyces
Lysate 2.80 25% Soln. Extract BUTYLENE Ashland Butylene Glycol 2.50
GLYCOL USP ONIPHEN P-23 Lipo/DD Chemco Phenoxyethanol (and)
Methylparaben 1.00 (and) Ethylparaben (and) Propylparben (and)
Butylparaben CANNERS 999 Open Sodium Chloride 1.00 TOTAL 100.00
PROCEDURE 1 - Using a homogenizer in the main tank, pre-mix FANCOL
ID and GEL BASE 1 until smooth. 2 - When homogeneous, add remaining
"A" ingredients in order indicated, mixing well between each
addition, and continue to mix for 15 minutes. 3 - In a separate
vessel, pre-blend "B" ingredients. 4 - When well blended, switch
main tank agitation to prop mixing, add pre-blend to batch, and
continue to mix for 45 minutes. 5 - In a separate vessel, pre-blend
"C" ingredients in order indicated, mixing well between each
addition until homogeneous. 6 - When homogeneous, add "C" pre-blend
to batch, and continue to mix for at least 15 minutes.
Specifications pH: N/A Viscosity: >20,000 cps
[0029] Those of ordinary skill in the art will appreciate that the
commercially-available ingredients listed above are exemplary only,
and that the elements in the formulation may be obtained using
ingredients other than those listed above. In addition, those of
ordinary skill in the art will appreciate that the amount of any
ingredient or group of ingredients listed above can be varied
depending on the desired concentration of elements in the
formulation.
[0030] This gel-based formulation allows the skin to appear
undamaged while simultaneously delivering the LYCE biofactors to
repair skin. The wound healing factor enhances skin repair by
facilitating oxygen utilization of fibroblasts and metabolic
activity, which helps lead to greater and more rapid collagen and
elastin production. The formulation is designed to spread smoothly,
to deliver color, maintain gas permeability, and stimulate oxygen
consumption at wounds.
[0031] The gel-based formulation and methods according to the
present invention have been disclosed in detail in connection with
the preferred embodiments, but these embodiments are disclosed by
way of examples only and are not to limit the scope of the present
invention, which is defined by the claims that follow. One of
ordinary skill in the art will appreciate many variations and
modifications within the scope of this invention.
* * * * *