U.S. patent application number 11/500931 was filed with the patent office on 2009-08-27 for radioisotope t1-201 production process.
This patent application is currently assigned to ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCH. Invention is credited to Mao-Hsung Chang, Jenn-Tzong Chen, Ting-Shien Duh, Sun-Rong Huang, Wuu-Jyh Lin, Chien-Hsin Lu, Ying-Ming Tsai.
Application Number | 20090211917 11/500931 |
Document ID | / |
Family ID | 40973385 |
Filed Date | 2009-08-27 |
United States Patent
Application |
20090211917 |
Kind Code |
A1 |
Lin; Wuu-Jyh ; et
al. |
August 27, 2009 |
RADIOISOTOPE T1-201 PRODUCTION PROCESS
Abstract
A radioisotope Tl-201 is produced. The process includes
electroplating, irradiating, dissolving precipitating, ion
exchanging, decaying and filtering. The Tl-201 obtained is a liquid
having a high purity.
Inventors: |
Lin; Wuu-Jyh; (Longtan
Township, TW) ; Duh; Ting-Shien; (Longtan Township,
TW) ; Tsai; Ying-Ming; (Pingjhen City, TW) ;
Huang; Sun-Rong; (Longtan Township, TW) ; Lu;
Chien-Hsin; (Longtan Township, TW) ; Chang;
Mao-Hsung; (Hukou Township, TW) ; Chen;
Jenn-Tzong; (Taipei City, TW) |
Correspondence
Address: |
TROXELL LAW OFFICE PLLC
5205 LEESBURG PIKE, SUITE 1404
FALLS CHURCH
VA
22041
US
|
Assignee: |
ATOMIC ENERGY COUNCIL-INSTITUTE OF
NUCLEAR ENERGY RESEARCH
Taoyuan
TW
|
Family ID: |
40973385 |
Appl. No.: |
11/500931 |
Filed: |
August 9, 2006 |
Current U.S.
Class: |
205/498 |
Current CPC
Class: |
G21G 1/001 20130101;
G21G 2001/0078 20130101; G21G 1/10 20130101 |
Class at
Publication: |
205/498 |
International
Class: |
C25B 1/24 20060101
C25B001/24 |
Claims
1. A radioisotope Tl-201 production process, comprising steps of:
(a) Electroplating: wherein a Tl-203 solid target material is
obtained from a plated target material of Tl-203 through
electroplating; (b) Irradiating: wherein said Tl-203 solid target
material is irradiated with a proton beam by using a cyclotron; (c)
Processing a first chemical separation: wherein said Tl-203 solid
target material is dissolved with a strong acid liquid to be
separated into a Tl-201 liquid and a Pb-201 liquid with impurities
filtered out; (d) Decaying: wherein said Pb-201 liquid is obtained
to be decayed into a Tl-201 liquid; and (e) Processing a second
chemical separation: wherein a Tl-201 liquid having a high purity
is obtained through filtering. wherein said step (c) comprises
steps of: (c1) Dissolving: wherein, after said irradiating, said
Tl-203 solid target material is dissolved with a strong acid liquid
to obtain a Pb-201 solution and a Tl-203 solution: (c2) Processing
a precipitation: wherein ammonia (NH.sub.3) and water are applied
to said Pb-201 solution and said Tl-203 solution for a
precipitation to obtain a Tl-201 liquid and a Pb-201 liquid; and
(c3) Processing a first ion exchange: wherein hydrochloric acid
(HCl) is applied to said Tl-201 liquid and said Pb-201 liquid for
an ion exchange by using a resin with impurities filtered out.
wherein said strong acid liquid used in step (c1) is a solution of
nitric acid having ferric iron (HNO.sub.3/Fe.sub.3/H.sub.2O),
wherein step (e) is a second ion exchange; and wherein an HCl
having sulfur dioxide (SO.sub.2) is applied to said Tl-201 liquid
to obtain a Tl-201 liquid having a high purity through a second ion
exchange by using a resin.
2. The process according to claim 1, wherein an irradiation energy
of said cyclotron in step (b) is located between 15 mega electron
volts (MeV) and 40 MeV.
3-5. (canceled)
6. A radioisotope Tl-201 production process, comprising steps of:
(a) Electroplating: wherein a Tl-203 solid target material is
obtained from a plated target material of Tl-203 through
electroplating; (b) Irradiating: wherein said Tl-203 solid target
material is irradiated with a proton beam by using a cyclotron;
(c1) Dissolving: wherein, after said irradiating, said Tl-203 solid
target material is dissolved with a strong acid liquid to obtain a
Pb-201 solution and a Tl-203 solution; (c2) Processing a
precipitation: wherein NH.sub.3 and water are applied to said
Pb-201 solution and said Tl-203 solution for a precipitation to
obtain a Tl-201 liquid and a Pb-201 liquid; (c3) Processing a first
ion exchange: wherein HCl is applied to said Tl-201 liquid and said
Pb-201 liquid for an ion exchange by using a resin with impurities
filtered out; (d) Decaying: wherein said Pb-201 liquid is obtained
to be decayed into a Tl-201 liquid; and (e1) Processes a second ion
exchange: wherein an HCl having SO.sub.2 is applied to said Tl-201
liquid to obtain a Tl-201 liquid having a high purity through an
second ion exchange by using a resin, wherein said strong acid
liquid used in step (c1) is HNO.sub.3/Fe.sub.3/H.sub.2O.
7. The process according to claim 6, wherein an irradiation energy
of said cyclotron in step (b) is located between 15 MeV and 40
MeV.
8. (canceled)
Description
FIELD OF THE INVENTION
[0001] The present invention relates to producing Tl-201; more
particularly, relates to quickly filtering out a high-purity Tl-201
liquid.
DESCRIPTION OF THE RELATED ART
[0002] Tl-201 thallous chloride (.sup.201TlCl.sub.2) can be
absorbed by heart muscle to be gathered at the heart muscle.
Therefore, Tl-201 can be used in a myocardial image for diagnosing
heart disease; and can be applied in other medical diagnoses, like
a tumor image. Hence, Tl-201 is the most commonly used radioisotope
in division of nuclear medicine.
[0003] To produce a Tl-201, as revealed in "Production of Tl-201
and Pb203 via Proton Induced Nuclear Reaction on Natural Thallium",
by Qaim S. M., Weinreich R. and Ollig H., International Journal of
Applied Radiation and Isotopes, 30 (1979) pp. 85-95, Tl-201 is
directly washed out. But the Tl-201 directly washed out quite often
contains impurities so that its purity is not good. Hence, the
prior art does not fulfill users' requests on actual use.
SUMMARY OF THE INVENTION
[0004] The main purpose of the present invention is to form a
Tl-203 solid target material through electroplating, irradiate the
Tl-203 solid target material with a proton beam, dissolve the
Tl-203 solid target material to process through a first chemical
separation and a second chemical separation, and quickly filter out
a high-purity Tl-201 liquid.
[0005] To achieve the above purpose, the present invention is a
radioisotope Tl-201 production process, where a Tl-203 solid target
material is obtained from a plated target material of Tl-203
through electroplating; the Tl-203 solid target material is
irradiated with a proton beam by using a cyclotron; the Tl-203
solid target material is dissolved with a strong acid liquid to
obtain a Pb-201 solution and a Tl-203 solution; ammonia and water
are added for a precipitation to separate a Tl-201 liquid and a
Pb-201 liquid out; hydrochloric acid is added for a first ion
exchange with a resin while impurities are filtered out; the Pb-201
liquid is taken out to be decayed into a Tl-201 liquid; and a
hydrochloric acid (HCl) having sulfur dioxide (SO.sub.2) is added
to the Tl-201 liquid to obtain a Tl-201 liquid having a high purity
through a second ion exchange by using a resin. Accordingly, a
novel radioisotope Tl-201 production process is obtained.
BRIEF DESCRIPTION OF THE DRAWING
[0006] The present invention will be better understood from the
following detailed description of the preferred embodiment
according to the present invention, taken in con junction with the
accompanying drawings, in which
[0007] FIG. 1 is the plot view showing the process flow of the
preferred embodiment according to the present invention; and
[0008] FIG. 2 is the detailed view showing the flow chart of the
preferred embodiment.
DESCRIPTION OF THE PREFERRED EMBODIMENT
[0009] The following description of the preferred embodiment is
provided to understand the features and the structures of the
present invention.
[0010] Please refer to FIG. 1, which is a plot view showing a
process flow of a preferred embodiment according to the present
invention. As shown in the figure, the present invention is a
radioisotope Tl-201 production process, comprising electroplating
1, irradiating 2, processing a first chemical separation 3,
decaying 4 and processing a second chemical separation 5, where the
first chemical separation 3 comprises dissolving 31, processing a
precipitation 32 and processing a first ion exchange 33; and the
second chemical separation 5 is a second ion exchange. Thus, a
novel radioisotope Tl-201 production process is obtained for
acquiring a Tl-201 liquid having a high purity.
[0011] Please refer to FIG. 2, which is a detailed view showing a
flow chart of the preferred embodiment. As shown in the figure,
when producing a radioisotope Tl-201 according to the present
invention, the following steps are processed:
[0012] (a) Electroplating 1: A Tl-203 solid target material 12 is
obtained from a plated target material 11 of Tl-203 through
electroplating.
[0013] (b) Irradiating 2: The Tl-203 solid target material 12 is
irradiated with a proton beam by using a cyclotron 21, where an
irradiation energy of the cyclotron 21 is located between fifteen
mega electron volts (MeV) and forty MeV.
[0014] (c) Processing a first chemical separation: The first
chemical separation 3 comprises the following steps: [0015] (c1)
Dissolving 31: After the irradiating, the Tl-203 solid target
material 12 is dissolved with a strong acid liquid 34 to obtain a
Pb-201 solution 35 and a Tl-203 solution 36, where the strong acid
liquid 34 is a solution of nitric acid having ferric iron
(HNO3/Fe3/H2O). [0016] (c2) Processing a precipitation 32: Ammonia
(NH3) and water 321 are added to the Pb-201 solution 35 and the
Tl-203 solution 36 for a precipitation to separate out a Tl-201
liquid 37 and a Pb-201 liquid 38; and [0017] (c3) Processing a
first ion exchange 33: Hydrochloric acid (HCl) 331 is added to the
Tl-201 liquid 37 and the Pb-201 liquid 38 for a first ion exchange
by using a resin 332 with impurities filtered out;
[0018] (d) Decaying 4: The Pb-201 liquid is taken out to be decayed
into a Tl-201 liquid 41.
[0019] (e) Processing a second chemical separation: And a second
chemical separation 5 is processed, which is a second ion exchange
51. [0020] (e1) Processing a second ion exchange 51: An HCl acid
having sulfur dioxide (SO.sub.2) 511 is added to the Tl-201 liquid
41 to obtain a Tl-201 liquid 52 having a high purity through a
second ion exchange by using a resin 512.
[0021] Thus, a novel radioisotope Tl-201 production process is
obtained.
[0022] To sum up, the present invention is a radioisotope Tl-201
production process, where a Tl-203 solid target material is formed
through an electroplating; the Tl-203 solid target material is
irradiated with a proton beam; the Tl-203 solid target material is
dissolved to be processed through a first chemical separation and a
second chemical separation; and a Tl-201 liquid is quickly filtered
out, which has a high purity.
[0023] The preferred embodiment herein disclosed is not intended to
unnecessarily limit the scope of the invention. Therefore, simple
modifications or variations belonging to the equivalent of the
scope of the claims and the instructions disclosed herein for a
patent are all within the scope of the present invention.
* * * * *