U.S. patent application number 12/262215 was filed with the patent office on 2009-07-09 for influenza hemagglutinin and neuraminidase variants. This patent application is currently assigned to Medlmmune, LLC. Invention is credited to George Kemble, Chongguang Liu, Chin-Fen Yang.
Application Number | 20090175898 12/262215 |
Document ID | / |
Family ID | 36992198 |
Filed Date | 2009-07-09 |
United States Patent Application | 20090175898 |
Kind Code | A1 |
Yang; Chin-Fen ; et al. | July 9, 2009 |
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
Inventors: | Yang; Chin-Fen; (San Jose, CA) ; Kemble; George; (Saratoga, CA) ; Liu; Chongguang; (Fremont, CA) |
Correspondence Address: |
MEDIMMUNE, LLC;Jonathan Klein-Evans ONE MEDIMMUNE WAY GAITHERSBURG MD 20878 US |
Assignee: | Medlmmune, LLC Gaithersburg MD |
Family ID: | 36992198 |
Appl. No.: | 12/262215 |
Filed: | October 31, 2008 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
11368246 | Mar 6, 2006 | 7459162 | ||
12262215 | ||||
60659832 | Mar 8, 2005 | |||
Current U.S. Class: | 424/199.1 ; 435/235.1; 435/239 |
Current CPC Class: | A61K 2039/5254 20130101; C12N 2760/16134 20130101; A61P 31/16 20180101; C07K 14/005 20130101; C12N 9/2402 20130101; A61K 39/12 20130101; A61K 2039/525 20130101; C12N 2760/16234 20130101; C12Y 302/01018 20130101; C12N 7/045 20130101; C12N 2760/16122 20130101; C12N 2760/16222 20130101; A61P 37/04 20180101; C07K 14/11 20130101; A61K 39/145 20130101 |
Class at Publication: | 424/199.1 ; 435/235.1; 435/239 |
International Class: | A61K 39/145 20060101 A61K039/145; C12N 7/01 20060101 C12N007/01; C12N 7/02 20060101 C12N007/02; A61P 31/16 20060101 A61P031/16 |
Sequence CWU 1
1
9611745DNAinfluenza A virus 1caggggataa ttctattaac catgaagact
atcattgctt tgagctacat tttatgtctg 60gttttcgctc aaaaacttcc cggaaatgac
aacagcacag caacgctgtg cctgggacat 120catgcagtgc caaacggaac
gctagtgaaa acaatcacga atgatcaaat tgaagtgact 180aatgctactg
agttggttca gagttcctca acaggtagaa tatgcggcag tcctcaccga
240atccttgatg gaaaaaactg cacactgata gatgctctat tgggagaccc
tcattgtgat 300ggcttccaaa ataaggaatg ggaccttttt gttgaacgca
gcaaagctta cagcaactgt 360tacccttatg atgtgccgga ttatgcctcc
cttaggtcac tagttgcctc atcaggcacc 420ctggagttta tcaatgaaga
cttcaattgg actggagtcg ctcaggatgg gggaagctat 480gcttgcaaaa
gaggatctgt taacagtttc tttagtagat tgaattggtt gcacaaatta
540gaatacaaat atccagcgct gaacgtgact atgccaaaca atggcaaatt
tgacaaattg 600tacatttggg gggttcacca cccgagcacg gacagtgacc
aaaccagcct atatgttcga 660gcatcaggga gagtcacagt ctctaccaaa
agaagccaac aaactgtaac cccgaatatc 720gggtctagac cctgggtaag
gggtcagtcc agtagaataa gcatctattg gacaatagta 780aaaccgggag
acatactttt gattaatagc acagggaatc taattgctcc tcggggttac
840ttcaaaatac gaaatgggaa aagctcaata atgaggtcag atgcacccat
tggcaactgc 900agttctgaat gcatcactcc aaatggaagc attcccaatg
acaaaccttt tcaaaatgta 960aacagaatca catatggggc ctgccccaga
tatgttaagc aaaacactct gaaattggca 1020acagggatgc ggaatgtacc
agagaaacaa actagaggca tattcggcgc aatcgcaggt 1080ttcatagaaa
atggttggga gggaatggta gacggttggt acggtttcag gcatcaaaat
1140tctgagggca caggacaagc agcagatctt aaaagcactc aagcagcaat
cgaccaaatc 1200aacgggaaac tgaataggtt aatcgagaaa acgaacgaga
aattccatca aatcgaaaaa 1260gaattctcag aagtagaagg gagaattcag
gacctcgaga aatatgttga agacactaaa 1320atagatctct ggtcttacaa
cgcggagctt cttgttgccc tggagaacca acatacaatt 1380gatctaactg
actcagaaat gaacaaactg tttgaaaaaa caaggaagca actgagggaa
1440aatgctgagg acatgggcaa tggttgcttc aaaatatacc acaaatgtga
caatgcctgc 1500atagggtcaa tcagaaatgg aacttatgac catgatgtat
acagagacga agcattaaac 1560aaccggttcc agatcaaagg tgttgagctg
aagtcaggat acaaagattg gatcctatgg 1620atttcctttg ccatatcatg
ctttttgctt tgtgttgttt tgctggggtt catcatgtgg 1680gcctgccaaa
aaggcaacat taggtgcaac atttgcattt gagtgcatta attaaaaaca 1740ccctg
174521429DNAinfluenza A virus 2aaagataata acaattggct ctgtttctct
cactattgcc acaatatgct tccttatgca 60aattgccatc ctggtaacta ctgtaacatt
gcacttcaag caatatgagt gcaactcccc 120cccaaacaac caagtaatgc
tgtgtgaacc aacaataata gaaagaaaca taacagagat 180agtgtatctg
accaacacca ccatagagaa agaaatatgc cccaaactag cagaatacag
240aaattggtca aagccgcaat gtaaaattac aggatttgca cctttttcta
aggacaattc 300aattcggctt tcagctggtg gagacatttg ggtgacaaga
gaaccttatg tgtcatgcga 360tcctggcaag tgttatcaat ttgcccttgg
acagggaaca acactaaaca acaggcactc 420aaatgacaca gtacatgata
ggacccctta tcgaacccta ttgatgaatg agttgggtgt 480tccatttcat
ttgggaacca agcaagtgtg catagcatgg tccagctcaa gttgtcacga
540tggaaaagca tggctgcatg tttgtgtaac tgggcatgat gaaaatgcaa
ctgctagctt 600catttacgat gggaggcttg tagatagtat tggttcatgg
tccaaaaata tcctcaggac 660ccaggagtcg gaatgcgttt gtatcaatgg
aacttgtaca gtagtaatga ctgatggaag 720tgcttcagaa agagctgata
ctaaaatact attcattgaa gaggggaaaa tcgttcatat 780tagcccattg
tcaggaagtg ctcagcatgt cgaggagtgc tcctgttatc ctcgatatcc
840tggtgtcaga tgtgtctgca gagacaactg gaaaggctcc aataggccca
tcgtagatat 900aaatgtgaaa gattatagca ttgtttccag ttatgtgtgc
tcaggacttg ttggagacac 960acccagaaaa aacgacagct ccagcagtag
ctattgccgg aatcctaaca atgagaaagg 1020gagtcatgga gtgaaaggct
gggcctttga tgatggaaat gacgtgtgga tgggaagaac 1080gatcagcgag
gagttacgct caggttatga aaccttcaaa gtcattggag gctggtccaa
1140acctaactcc aaattgcaga taaataggca agtcatagtt gacagaggta
ataggtccgg 1200ttattctggt attttctctg ttgaaggcaa aagctgcatc
aatcggtgct tttatgtgga 1260gttgataagg ggaaggaaac aggaaactga
agtctggtgg acctcaaaca gtattgttgt 1320gttttgtggc acctcaggta
catatggaac aggctcatgg ccctgatggg gcggacatca 1380atctcatgcc
tatataagct ttcgcaattt tagaaaaaaa ctccttgtt 142931755DNAinfluenza A
virus 3agcaaaagca ggggataatt ctattaacca tgaagactat cattgctttg
agctacattt 60tatgtctggt tttcgctcaa aaacttcccg gaaatgacaa cagcacagca
acgctgtgcc 120tgggacacca tgcagtgcca aacggaacgc tagtgaaaac
aatcacgaat gatcaaattg 180aagtgactaa tgctactgag ctggttcaga
gttccccaac aggtagaata tgcgacagcc 240ctcaccgaat ccttgatgga
aagaactgca cactgataga tgctctattg ggagaccctc 300attgtgatgg
cttccaaaat aaggaatggg acctttttgt tgaacgcagc aaagcttaca
360gcaactgtta cccttatgat gtgccggatt atgcctccct taggtcacta
gttgcctcat 420caggcaccct ggagtttatc aacgaaaact tcaattggac
tggagtcgct caggatggga 480aaagctatgc ttgcaaaagg ggatctgtta
acagtttctt tagtagattg aattggttgc 540acaaattaga atacaaatat
ccagcgctga acgtgactat gccaaacaat ggcaaatttg 600acaaattgta
catttggggg gttcaccacc cgagcacgga cagtgtccaa accagcctat
660atgtccgagc atcagggaga gtcacagtct ctaccaaaag aagccaacaa
actgtaatcc 720cggatatcgg gtatagacca tgggtaaggg gtcagtccag
tagaataagc atctattgga 780caatagtaaa accgggagac atacttttga
ttaatagcac agggaatcta attgctcctc 840ggggttactt caaaatacga
aatgggaaaa gctcaataat gaggtcagat gcacccattg 900gcaactgcag
ttctgaatgc atcactccaa atggaagcat tcccaatgac aaaccttttc
960aaaatgtaaa caggatcaca tatggggcct gccccagata tgttaagcaa
aacactctga 1020aattggcaac agggatgcgg aatgtaccag agaaacaaac
tagaggcata ttcggcgcaa 1080tcgcaggttt catagaaaat ggttgggagg
gaatggtaga cggttggtac ggtttcaggc 1140atcaaaattc tgagggcaca
ggacaagctg cagatcttaa aagcactcaa gcagcaatcg 1200accaaatcaa
cgggaaactg aataggttag tcgagaaaac gaacgagaaa ttccatcaaa
1260tcgaaaaaga attctcagaa gtagaaggga gaattcagga cctcgagaaa
tatgttgaag 1320acactaaaat agatctctgg tcttacaatg cggaacttct
tgttgctctg gagaaccaac 1380atacaattga tctaactgac tcagaaatga
acaaactgtt tgaaagaaca aggaagcaac 1440tgagggaaaa tgctgaggac
atgggcaatg gttgtttcaa aatataccac aaatgtgaca 1500atgcctgcat
agggtcaatc agaaatggaa cttatgacca tgatgtatac agagacgaag
1560cattaaacaa ccggttccag atcaaaggtg ttgagctgaa gtcaggatac
aaagattgga 1620ttctatggat ttcctttgcc atatcgtgct ttttgctttg
tgttgttttg cttgggttca 1680tcatgtgggc ctgccaaaaa ggcaacatta
ggtgcaacat ttgcatttga gtgcattaat 1740taaaaacacc cttgt
175541354DNAinfluenza A virus 4gaaaatgaat ccaaatcaaa agataataac
aattggctct gtttctctca ctattgccac 60aatatgcttc cttatgcaaa ttgccatcct
ggtaactact gtaacattgc atttcaagca 120atatgagtgc aactcccccc
caaacaacca agtaatgctg tgtgaaccaa caataataga 180aagaaacata
acagagatag tgtatctgac caacaccacc atagagaaag aaatatgccc
240caaactagca gaatacagaa attggtcaaa gccgcaatgt aaaattacag
gatttgcacc 300tttttctaag gacaattcaa ttcggctttc cgctggtgga
gacatttggg tgacaagaga 360accttatgtg tcatgcgatc ctggcaagtg
ttatcaattt gccctcggac agggaacaac 420actaaacaac aggcattcaa
atgacacagt acatgatagg accccttatc gaaccctatt 480gatgaatgag
ttgggtgttc catttcattt gggaaccaag caagtgtgca tagcatggtc
540cagctcaagt tgtcacgatg gaaaagcatg gctgcatgtt tgtgtaactg
ggcatgatga 600aaatgcaact gctagcttca tttacgatgg gaggcttgta
gatagtattg gttcatggtc 660caaaaatatc ctcaggaccc aggagtcgga
atgcgtttgt atcaatggaa cttgtacagt 720agtaatgact gatggaagtg
cttcagaaag agctgatact aaaatactat tcattgaaga 780ggggaaaatc
gttcatatta gcccattgtc aggaagtgct cagcatgtcg aggagtgctc
840ctgttatcct cgatatcctg gtgtcagatg tgtctgcaga gacaactgga
aaggctccaa 900taggcccatc gtagatataa atgtgaaaga ttatagcatt
gtttccagtt atgtgtgctc 960aggacttgtt ggagacacac ccagaaaaaa
cgacagctcc agcagtagct attgctggaa 1020tcctaacaat gagaaagggg
gtcatggagt gaaaggctgg gcctttgatg atggaaatga 1080cgtgtggatg
ggaagaacga tcagcgagga gttacgctca ggttatgaaa ccttcaaagt
1140cattggaggc tggtccaaac ctaactccaa attgcagata aataggcaag
tcatagttga 1200cagaggtaat aggtccggtt attctggtat tttctctgtt
gaaggcaaaa gctgcatcaa 1260tcggtgcttt tatgtggagt tgataagggg
aaggaaacag gaaactgaag tctggtggac 1320ctcaaacagt attgttgtgt
tttgtggcac ttca 135451762DNAinfluenza A virus 5agcaaaagca
ggggataatt ctattaacca tgaagactat cattgctttg agctacattt 60tatgtctggt
tttcgctcaa aaacttcccg gaaatgacaa cagcacggca acgctgtgcc
120tgggacacca tgcagtgcca aacggaacgc tagtgaaaac aatcacgaat
gaccaaattg 180aagtgactaa tgctactgag ctggttcaga gttcctcaac
aggtagaata tgcgacagtc 240ctcaccgaat ccttgatgga aaaaactgca
cactgataga tgctctattg ggagaccctc 300attgtgatgg cttccaaaat
aaggaatggg acctttttgt tgaacgcagc aaagcttaca 360gcaactgtta
cccttatgat gtgccggatt atgcttccct taggtcacta gttgcctcat
420ccggcaccct ggagtttacc aatgaaggct tcaattggac tggagtcgct
caggatggaa 480caagctatgc ttgcaaaagg ggatctgtta aaagtttctt
tagtagattg aattggttgc 540acaaattaga atacaaatat ccagcactga
acgtgactat gccaaacaat gacaaatttg 600acaaattgta catttggggg
gttcaccacc cgagtacgga cagtgaccaa accagcatat 660atgttcaagc
atcagggaga gtcacagtct ctaccaaaag aagccaacaa actgtaatcc
720cgaatatcgg gtctagaccc tgggtaaggg ggatctccag cagaataagc
atctattgga 780caatagtaaa accgggagac atacttttga ttaacagcac
agggaatcta attgctcctc 840ggggttactt caaaatacga agtgggaaaa
gctcaataat gaggtcagat gcacccattg 900gcaactgcaa ttctgaatgc
atcactccaa atggaagcat tcccaatgac aaaccttttc 960aaaatgtaaa
caggatcaca tatggggcct gtcccagata tgttaagcaa aacactctga
1020aattggcaac agggatgcgg aatgtaccag agaaacaaac tagaggcata
ttcggcgcaa 1080tcgcaggttt catagaaaat ggttgggagg gaatggtaga
cggttggtac ggtttcaggc 1140atcaaaattc tgagggcaca ggacaagcag
cagatcttaa aagcactcaa gcagcaatca 1200accaaatcaa cgggaaactg
aataggttaa tcgagaaaac gaacgagaaa ttccatcaaa 1260tcgaaaaaga
attctcagaa gtagaaggga gaattcagga cctcgagaaa tatgttgaag
1320acactaaaat agatctctgg tcttacaacg cggagcttct tgttgccctg
gagaaccaac 1380atacaattga tctaactgac tcagaaatga acaaactgtt
tgaaagaaca aggaagcaac 1440tgagggaaaa tgctgaggac atgggcaatg
gttgcttcaa aatataccac aaatgtgaca 1500atgcctgcat agggtcaatc
agaaatggaa cttatgacca tgatgtatac agagacgaag 1560cattaaacaa
ccggttccag atcaaaggtg ttgagctgaa gtcaggatac aaagattgga
1620tcctatggat ttcctttgcc atatcatgct ttttgctttg tgttgttctg
ctggggttca 1680tcatgtgggc ctgccaaaaa ggcaacatta ggtgcaacat
ttgcatttga gtgcattaat 1740taaaaacacc cttgtttcta ct
176261451DNAinfluenza A virus 6agcaaaagca ggagtgaaaa tgaatccaaa
tcaaaagata ataactattg gctctgtttc 60tctcactatt gccacaatat gcttccttat
gcaaattgcc atcctggtaa ctactgtaac 120attacatttc aagcaatatg
aatgcaactc ccccccaaac aaccaagtaa tgctgtgtga 180accaacaata
atagaaagaa acataacaga gatagtgtat ctgaccaaca ccaccataga
240gaaggaaata tgccccaaac tagcagaata cagaaattgg tcaaagccgc
aatgtaaaat 300tacaggattt gcaccttttt ctaaggacaa ttcaattcgg
ctttccgctg gtggggacat 360ttgggtgaca agagaacctt atgtgtcatg
cgatcctgac aagtgttatc aatttgccct 420tggacaggga acaacactaa
acaacaggca ttcaaatgac acagtacatg ataggacccc 480ttatcgaacc
ctattgatga atgagttggg tgttccattt catttgggaa ccaagcaagt
540gtgcatagca tggtccagct caagttgtca cgatggaaaa gcatggctgc
atgtttgtgt 600aactgggcat gatgaaaatg caactgctag cttcatttac
gatgggaggc ttgtagatag 660tattggttca tggtccaaaa aaatcctcag
gacccaggag tcggaatgcg tttgtatcaa 720tggaacttgt acagtagtaa
tgactgatgg aagtgcttca ggaagagctg atactaaaat 780actattcatt
gaagagggga aaatcgttca tattagccca ttgtcaggaa gtgctcagca
840tgtcgaggag tgctcctgtt atcctcgata ttctggtgtc agatgtgtct
gcagagacaa 900ctggaaaggc tccaataggc ccatcgtaga tataaatgtg
aaagattata gcattgtttc 960cagttatgtg tgctcaggac ttgttggaga
cacacccaga aaaaacgaca gctccagcag 1020tagccattgc ctgaatccta
acaatgagga agggggtcat ggagtgaaag gctgggcctt 1080tgatgatgga
aatgacgtgt ggatgggaag aacgatcagc gagaagttac gctcaggtta
1140tgaaaccttc aaagtcattg gaggctggtc caaacctaac tccaaattgc
agataaatag 1200acaagtcata gttgacagag gtaataggtc cggttattct
ggtattttct ctgttgaagg 1260caaaagctgc atcaatcggt gcttttatgt
ggagttgata aggggaagga aacaggaaac 1320tgaagtctgg tggacctcaa
acagtattgt tgtgttttgt ggcacctcag gtacatatgg 1380aacaggctca
tggcctgatg gggcggacat caatctcatg cctatataag ctttcgcaat
1440tttagaaaaa a 145171762DNAinfluenza A virus 7agcaaaagca
ggggataatt ctattaacca tgaagactat cattgctttg agctacattt 60tatgtctggt
tttcgctcaa aaaattcccg gaaatgacaa cagcacggca acgctgtgcc
120tgggacacca tgcagtgcca aacggaacgc tagtgaaaac aatcacgaat
gaccaaattg 180aagtgactaa tgctactgag ctggttcaga gttcctcaac
aggtagaata tgcgacagtc 240ctcaccgaat ccttgatgga gaaaactgca
cactgataga tgctctattg ggagaccctc 300attgtgatgg cttccaaaat
aaggaatggg acctttttgt tgaacgcagc aaagcctaca 360gcaactgtta
cccttatgat gtgccggatt atgcctccct taggtcacta gttgcctcat
420ccggcaccct ggagtttaac aatgaaagct tcaattggac tggagtcgct
cagaatggaa 480caagctatgc ttgcaaaagg agttctatta aaagtttctt
tagtagattg aattggttgc 540accaattaaa atacaaatat ccagcactga
acgtgactat gccaaacaat gacaaatttg 600acaaattgta catttggggg
gttcaccacc cgagtacgga cagtgaccaa accagcatat 660atgctcaagc
atcagggaga gtcacagtct ccaccaaaag aagccaacaa actgtaatcc
720cgaatatcgg atctagaccc tgggtaaggg gtatctccag cagaataagc
atccattgga 780caatagtaaa accgggagac atacttttga ttaacagcac
agggaatcta attgctcctc 840ggggttactt caaaatacga agtgggaaaa
gctcaataat gaggtcagat gcacccattg 900gcaaatgcaa ttctgaatgc
atcactccaa atggaagcat tcccaatgac aaaccatttc 960aaaatgtaaa
caggatcaca tatggggcct gtcccagata tgttaagcaa aacactctga
1020aattggcaac agggatgcgg aatgtaccag agaaacaaac tagaggcata
ttcggcgcaa 1080tcgcaggttt catagaaaat ggttgggagg gaatggtaga
cggttggtac ggtttcaggc 1140atcaaaattc tgagggcaca ggacaagcag
cagatcttaa aagcactcaa gcagcaatca 1200accaaatcaa cgggaaactg
aataggttaa tcgagaaaac gaacgagaaa ttccatcaaa 1260ttgaaaaaga
attctcagaa gtagaaggga gaattcagga cctcgagaaa tatgttgagg
1320acactaaaat agatctctgg tcgtacaacg cggagcttct tgttgccctg
gagaaccaac 1380atacaattga tctaactgac tcagaaatga acaaactgtt
tgaaagaaca aggaagcaac 1440tgagggaaaa tgctgaggat atgggcaatg
gttgtttcaa aatataccac aaatgtgaca 1500atgcctgcat agggtcaatc
agaaatggaa cttatgacca tgatgtatac agagacgaag 1560cattaaacaa
ccggttccag atcaaaggtg ttgagctgaa gtcaggatac aaagattgga
1620tcctatggat ttcctttgcc atatcatgtt ttttgctttg tgttgttttg
ctggggttca 1680tcatgtgggc ctgccaaaaa ggcaacatta ggtgcaacat
ttgcatttga gtgcattaat 1740taaaaacacc cttgtttcta ct
176281467DNAinfluenza A virus 8agcaaaagca ggagtaaaga tgaatccaaa
tcaaaagata ataacgattg gctctgtttc 60tctcactatt gccacaatat gcttccttat
gcaaattgcc atcctggtaa ctactgtaac 120attgcatttc aagcaatatg
aatgcagctc tcccccaaac aaccaagtaa tgctgtgtga 180accaacaata
atagaaagaa acataacaga gatagtgtat ctgaccaaca ccaccataga
240gaaggaaata tgccccaaac tagcagaata cagaaattgg tcaaagccac
aatgtaaaat 300tacaggattt gcaccttttt ctaaggacaa ttcaattcgg
ctttccgctg gtggggacat 360ttgggtgaca agggaacctt atgtgtcgtg
cgatcctgac aagtgttatc aatttgccct 420tggacaggga acaacactaa
acaacaggca ttcaaatgac acagtacatg ataggacccc 480ttatcgaacc
ctattgatga atgagttggg tgttccattt catttgggaa ccaagcaagt
540gtgcatagca tggtccagct caagttgtca cgatggaaaa gcatggctgc
atgtttgtgt 600aactgggcat gatgaaaatg caactgctag cttcatttac
gatgggaggc ttgtagatag 660tattggttca tggtccaaaa aaatcctcag
gacccaggag tcggaatgcg tttgtatcaa 720tggaacttgt acagtagtaa
tgactgatgg gagtgcttca ggaagagctg atactaaaat 780actattcatt
gaggagggga aaatcgttca tatcagccca ctgtcaggaa gtgctcagca
840tgtcgaggag tgctcctgtt atcctcgata tcctggtgtc agatgtgtct
gcagagacaa 900ctggaaaggc tccaataggc ccatcgtaga tataaatgta
aaggattata gcattgtttc 960cagttatgtg tgctcaggac ttgttggaga
cacacccaga aaaaacgaca gctccagcag 1020tagtcattgc ctgaatccta
acaatgagga agggggtcat ggagtgaaag gctgggcctt 1080tgatgatgga
aatgacgtgt ggatgggaag aacgatcagc gagaagttcc gctcaggtta
1140tgaaaccttc aaagtcattg aaggctggtc caaacctaac tccaaattgc
agataaatag 1200gcaagtcata gttgacagag gtaataggtc cggttattct
ggtattttct ctgttgaagg 1260caaaagctgc atcaatcggt gcttttatgt
ggagttgata aggggaagga aacaggaaac 1320tgaagtctgg tggacctcaa
acagtattgt tgtgttttgt ggcacctcag gtacatatgg 1380aacaggctca
tggcctgatg gggcggacat caatctcatg cctatataag ctttcgcaat
1440tttagaaaaa aactccttgt ttctact 146791762DNAinfluenza A virus
9agcaaaagca ggggataatt ctattaacca tgaagactat cattgctttg agctacattt
60tatgtctggt tttcgctcaa aaacttcccg gaaatgacaa cagcacggca acgctgtgcc
120tggggcacca tgcagtgtca aacggaacgc tagtgaaaac aatcacgaat
gaccaaattg 180aagtgactaa tgctactgag ctggttcaga gttcctcaac
aggtagaata tgcgacagtc 240ctcaccaaat ccttgatgga gaaaactgca
cactaataga tgctctattg ggagaccctc 300attgtgatgg cttccaaaat
aaggaatggg acctttttgt tgaacgcagc aaagcctaca 360gcaactgtta
cccttatgat gtgccggatt atgcctccct taggtcacta gttgcctcat
420ccggcacact ggagtttaac aatgaaagct tcaattggac tggagtcgct
cagaatggaa 480caagctctgc ttgcaaaagg ggatctaata aaagtttctt
tagtagattg aattggttgc 540accaattaaa atacaaatat ccagcactga
acgtgactat gccaaacaat gaaaaatttg 600acaaattgta catttggggg
gttctccacc cgagtacgga cagtgaccaa atcagcctat 660atgctcaagc
atcagggaga gtcacagtct ctaccaaaag aagccaacaa actgtaatcc
720cgaatatcgg atctagaccc tgggtaaggg gtgtctccag cagaataagc
atctattgga 780caatagtaaa accgggagac atacttttga ttaacagcac
agggaatcta attgctcctc 840ggggttactt caaaatacga agtgggaaaa
gctcaataat gaggtcagat gcacccattg 900gcaaatgcaa ttctgaatgc
atcactccaa atggaagcat tcccaatgac aaaccatttc 960aaaatgtaaa
caggatcaca tatggggcct gtcccagata tgttaagcaa aacactctga
1020aattggcaac agggatgcgg aatgtaccag agaaacaaac tagaggcata
ttcggcgcaa 1080tcgcgggttt catagaaaat ggttgggagg gaatggtgga
cggttggtac ggtttcaggc 1140atcaaaattc tgagggcaca ggacaagcag
cagatcttaa aagcactcaa gcagcaatca 1200accaaatcaa cgggaaactg
aataggttaa tcgagaaaac gaacgagaaa ttccatcaaa 1260ttgaaaaaga
attctcagaa gtagaaggga gaattcagga cctcgagaaa tatgttgagg
1320acactaaaat agatctctgg tcgtacaacg cggagcttct tgttgccctg
gagaaccaac 1380atacaattga tctaactgac tcagaaatga acaaactgtt
tgaaagaaca aagaagcaac 1440tgagggaaaa tgctgaggat atgggcaatg
gttgtttcaa aatataccac aaatgtgaca 1500atgcctgcat agggtcaatc
agaaatggaa cttatgacca tgatgtatac agagacgaag 1560cattaaacaa
ccggttccag atcaaaggtg ttgagctgaa gtcaggatac aaagattgga
1620tcctatggat ttcctttgcc atatcatgct ttttgctttg tgttgttttg
ctggggttca 1680tcatgtgggc ctgccaaaaa ggcaacatta ggtgcaacat
ttgcatttga gtgcattaat 1740taaaaacacc cttgtttcta ct
1762101466DNAinfluenza A virus 10agcaaaagca ggagtaaaga tgaatccaaa
tcaaaagata ataacgattg gctctgtttc 60tctcactatt gccacaatat gcttccttat
gcaaatagcc atcctggtaa ctactgtaac 120attgcatttc aagcaatatg
aatgcaactc ccccccaaac aaccaagtaa tgctgtgtga 180accaacaata
atagaaagaa acataacaga gatagtgtat ctgaccaaca ccaccataga
240gaaggaaata tgccccaaac tagcagaata cagaaattgg tcaaagccgc
aatgtaaaat 300tacaggattt gcaccttttt ctaaggataa ttcaattcgg
ctttccgctg gtggggacat 360ttgggtgaca agagaacctt atgtgtcatg
cgatcctgac aagtgttatc aatttgccct 420tggacaggga acaacactaa
acaacaggca ttcaaatgac acagtacatg ataggacccc 480ttatcgaacc
ctattgatga atgagttggg tgttccattt catttgggaa ccaagcaagt
540gtgtatagca tggtccagct caagttgtca cgatggaaaa gcatggctgc
atgtttgtgt 600aactgggcat gatgaaaatg caactgctag cttcatttac
gatgggagac ttgtagatag 660tattggttca tggtccaaaa aaatcctcag
gacccaggag tcggaatgcg tttgtatcaa 720tggaacttgt acagtagtaa
tgactgatgg gagtgcttca ggaagagctg atactaaaat 780acttttcatt
gaggagggga aaatcgttca tactagcaaa ttgtcaggaa gtgctcagca
840tgtcgaggag tgctcctgtt atcctcgata tcctggtgtc agatgtgtct
gcagagacaa 900ctggaaaggc tccaataggc ccatcgtaga tataaatgta
aaggattata gcattgtttc 960cagttatgtg tgctcaggac ttgttggaga
cacacccaga aaaaacgaca gctccagcag 1020tagccattgc ctggatccta
acaatgaaga agggggtcat ggagtgaaag gctgggcctt 1080tgatgatgga
aatgacgtgt ggatgggaag aacgatcagc gagaagtcac gctcaggtta
1140tgaaaccttc aaggtcattg aaggctggtc caaacctaac tccaaattgc
agataaatag 1200gcaagtcata gttgaaagag gtaatatgtc cggttattct
ggtattttct ctgttgaagg 1260caaaagctgc atcaatcggt gcttttatgt
ggagttgata aggggaagga aacaggaaac 1320tgaagtctgg tggacctcaa
acagtattgt tgtgttttgt ggcacctcag gtacatatgg 1380aacaggctca
tggcctgatg gggcggacat caatctcatg cctatataag ctttcgcaat
1440tttagaaaaa actccttgtt tctact 1466111762DNAinfluenza A virus
11agcaaaagca ggggataatt ctattaacca tgaagactat cattgcttta agctacattc
60tatgtctggt tttctctcaa aagcttcccg gaaatgacaa cagcacggca acgctgtgcc
120ttgggcacca tgcagtacca aacggaacga tagtgaaaac aatcacgaat
gaccaaattg 180aagttactaa tgctactgag ctggttcaga gttcctcaac
aggtggaata tgcgacagtc 240ctcatcagat ccttgatgga gaaaactgca
cactaataga tgctctattg ggagaccctc 300agtgtgatgg cttccaaaat
aagaaatggg acctttttgt tgaacgcagc aaagcctaca 360gcaactgtta
cccttatgat gtgccggatt atgcctccct taggtcacta gttgcctcat
420ccggcacact ggagtttaac aatgaaagct tcaattgggc tggagtcact
cagaatggaa 480caagctctgc ttgcaaaagg agatctaata aaagtttctt
tagtagattg aattggttga 540cccacttaaa atacaaatac ccagcattga
acgtgactat gccaaacaat gaaaaatttg 600acaaattgta catttggggg
gttcaccacc cggttacgga cagtgaccaa atcagcctat 660atgctcaagc
atcaggaaga atcacagtct ctaccaaaag aagccaacaa actgtaatcc
720cgaatatcgg atatagaccc agggtaaggg atatctccag cagaataagc
atctattgga 780caatagtaaa accgggagac atacttttga ttaacagcac
aggaaatcta attgctcctc 840ggggttactt caaaatacga agtgggaaaa
gctcaataat gagatcagat gcacccattg 900gcaaatgcaa ttctgaatgc
atcactccaa atggaagcat tcccaatgac aaaccatttc 960aaaatgtaaa
caggatcaca tatggggcct gtcccagata tgttaagcaa aacactctga
1020aattggcaac agggatgcga aatgtaccag agaaacaaac tagaggcata
tttggcgcaa 1080tcgcgggttt catagaaaat ggttgggagg gaatggtgga
cggttggtac ggtttcaggc 1140atcaaaattc tgagggcaca ggacaagcag
cagatctcaa aagcactcaa gcagcaatca 1200accaaatcaa tgggaaactg
aataggttaa tcgggaaaac aaacgagaaa ttccatcaga 1260ttgaaaaaga
attctcagaa gtagaaggga gaattcagga cctcgagaaa tatgttgagg
1320acactaaaat agatctctgg tcatacaacg cggagcttct tgttgccctg
gaaaaccaac 1380atacaattga tctaactgac tcagaaatga acaaactgtt
tgaaagaaca aagaagcaac 1440tgagggaaaa tgctgaggat atgggcaatg
gttgtttcaa aatataccac aaatgtgaca 1500atgcctgcat agagtcaatc
agaaatggaa cttatgacca tgatgtatac agagatgaag 1560cattaaacaa
ccggttccag atcaaaggtg ttgagctgaa gtcaggatac aaagattgga
1620tcctatggat ttcctttgcc atatcatgtt ttttgctttg tgttgctttg
ttggggttca 1680tcatgtgggc ctgccaaaaa ggcaacatta ggtgcaacat
ttgcatttga gtgcattaat 1740taaaaacacc cttgtttcta ct
1762121467DNAinfluenza A virus 12agcaaaagca ggagtaaaga tgaatccaaa
tcaaaagata ataacgattg gctctgtttc 60cctcaccatt tccacaatat gcttcttcat
gcaaattgcc atcctgataa ctactgtaac 120attgcatttc aagcaatatg
aattcaactc ccccccaaac aaccaagtga tgctgtgtga 180accaacaata
atagaaagaa acataacaga gatagtgtat ctgaccaaca ccaccataga
240gaaggaaata tgccccaaac tagcagaata cagaaattgg tcaaagccgc
aatgtaacat 300tacaggattt gcaccttttt ctaaggacaa ttcgattcgg
ctttccgctg gtggggacat 360ctgggtgaca agagaacctt atgtgtcatg
cgatcctgac aagtgttatc aatttgccct 420tggacaggga acaacactaa
acaacgtgca ttcaaatgac acagtacatg ataggacccc 480ttatcggacc
ctattgatga atgagttggg tgttccattt catctgggga ccaagcaagt
540gtgcatagca tggtccagct caagttgtca cgatggaaaa gcatggctgc
atgtttgtgt 600aacgggggat gatgaaaatg caactgctag cttcatttac
aatgggaggc ttgtagatag 660tattgtttca tggtccaaaa aaatcctcag
gacccaggag tcagaatgcg tttgtatcaa 720tggaacttgt acagtagtaa
tgactgatgg gagtgcttca ggaaaagctg atactaaaat 780actattcatt
gaggagggga aaattgttca tactagcaca ttatcaggaa gtgctcagca
840tgtcgaggag tgctcctgtt atcctcgata tcctggtgtc agatgtgtct
gcagagacaa 900ctggaaaggc tccaataggc ccatcgtaga tataaacata
aaggattata gcattgtttc 960cagttatgtg tgctcaggac ttgttggaga
cacacccaga aaaaacgaca gctccagcag 1020tagccattgc ttggatccaa
acaatgagga aggtggtcat ggagtgaaag gctgggcatt 1080tgatgatgga
aatgacgtgt ggatgggaag aacgatcagc gagaagttac gctcaggata
1140tgaaaccttc aaagtcattg aaggctggtc caaccctaac tccaaattgc
agataaatag 1200gcaagtcata gttgacagag gtaacaggtc cggttattct
ggtattttct ctgttgaagg 1260caaaagctgc atcaatcggt gcttttatgt
ggagttgata aggggaagaa aacaggaaac 1320tgaagtcttg tggacctcaa
acagtattgt tgtgttttgt ggcacctcag gtacatatgg 1380aacaggctca
tggcctgatg gggcggacat caatctcatg cctatataag ctttcgcaat
1440tttagaaaaa aactccttgt ttctact 1467131778DNAinfluenza A virus
13agcaaaagca ggggaaaata aaaacaacca aaatgaaagc aaaactacta gtcctgttat
60gtgcatttac agctacatat gcagacacaa tatgtatagg ctaccatgcg aacaactcaa
120ccgacactgt tgacacagta cttgagaaga acgtgacagt gacacactct
gtcaacctac 180ttgaggacag tcacaacgga aaactatgtc gactaaaggg
aatagcccca ctacaattgg 240gtaattgcag cgttgccgga tggatcttag
gaaacccaaa atgcgaatca ctgttttcta 300aggaatcatg gtcctacatt
gcagaaacac caaaccctga gaatggaaca tgttacccag 360ggtatttcgc
cgactatgag gaactgaggg agcaattgag ttcagtatca tcattcgaga
420gattcgaaat attccccaaa gaaagctcat ggcccaacca caccgtaacc
aaaggagtaa 480cgacatcatg ctcccataat gggaaaagca gtttttacag
aaatttgcta tggctgacga 540agaagaatgg cttgtaccca aatgtgagca
agtcctatgt aaacaacaaa gagaaagaag 600tccttgtact atggggtgtt
catcacccgt ctaacatagg ggaccaaagg gccatctatc 660atacagaaaa
tgcttatgtc tctgtagtgt cttcacatta tagcagaaga ttcaccccag
720aaatagcaaa aagacccaaa gtaagagatc aagaaggaag aattaactac
tactggactc 780tgctggaacc cggggacaca ataatatttg aggcaaatgg
aaatctaata gcgccatggt 840atgctttcgc actgagtaga ggctttgggt
caggaatcat cacctcaaac gcatcaatgg 900atgaatgtga cgcgaagtgt
caaacacccc agggagctat aaacagtagt cttcctttcc 960agaatgtaca
cccagtcaca ataggagagt gtccaaagta tgtcaggagt acaaaattaa
1020ggatggttac aggactaagg aacatcccat ccattcaatc cagaggtttg
tttggagcca 1080ttgccggttt cattgaaggg gggtggactg gaatgataga
tggatggtat ggttatcatc 1140atcagaatga acaaggatct ggctatgctg
cggaccaaaa aagcacacaa aatgccatta 1200acgggattac aaacaaggtg
aattctgtaa tcgagaaaat gaacactcaa ttcacagctg 1260tgggcaaaga
attcaacaaa ttagaaagaa ggatggaaaa cttaaataaa aaagttgatg
1320atggatttct ggacatttgg acatataatg cagaattgtt ggttctactg
gaaaatggaa 1380ggactttgga ttttcatgac tcaaatgtga agaatctgta
tgagaaagta aaaagccaat 1440tgaagaataa tgccaaagaa atagggaacg
ggtgttttga attctatcac aagtgtaaca 1500atgaatgcat ggaaagtgtg
aaaaatggaa cttatgacta tccaaaatat tccgaagaat 1560caaagttaaa
caggggaaaa attgatggag tgaaattgga atcaatggga gtctatcaga
1620ttctggcgat ctactcaact gtcgccagtt cactggtgct tttggtctcc
ctgggggcaa 1680tcagcttctg gatgtgttct aatgggtctt tgcagtgtag
aatatgcatc tgagaccaga 1740atttcagaaa tataagaaaa aacacccttg tttctact
1778141463DNAinfluenza A virus 14agcaaaagca ggagtttaaa atgaatccaa
atcaaaaaat aataatcata ggatcaatca 60gtatggcaat cggaataatt agtctaatat
tgcaaatagg aaatattatt tcaatatggg 120ctagccactc aatccaaact
ggaagtcaaa accacactgg aatatgcaac caaagaatca 180ttacatatga
aaatagcacc tgggtgaatc aaacatatgt taatattaac aacactaatg
240ttgttgctgg aaaggacaaa acttcagtga cattggccgg caattcatct
ctttgcccta 300tccgtgggtg ggctatatac acaaaagaca acagcataag
aattggttcc aaaggagatg 360tttttgtcat aagagagcct tttatatcat
gttctcactt ggaatgcaga accttttttc 420tgacccaagg tgctctatta
aatgacaagc attcaaatgg gaccgttaag gacagaagcc 480cttatagggc
cttaatgagc tgtcctctag gtgaagctcc gtctccatac aattcaagat
540ttgaatcagt tgcttggtca gcaagcgcat gccatgatgg catgggctgg
ctaacaatcg 600gaatttctgg tccagataat ggagcagtgg ctgtactaaa
atacaacggc ataataactg 660aaaccataaa aagttggaag aagcgaatat
taagaacaca agagtctgaa tgtgtctgtg 720tgaacggttc atgttttacc
ataatgaccg atggcccgag taatggggcc gcctcgtaca 780gaatcttcaa
aatcgagaag gggaaggtta ctaaatcaat agagttggat gcacccaatt
840atcattacga ggaatgttcc tgttacccag acaccggcac agtgatgtgt
gtgtgcaggg 900acaattggca cggttcaaat cgaccttggg tgtcttttaa
tcaaaacctg gattatcaaa 960taggatacat ctgcagtggg gtgttcggtg
acaatccgcg tcccaaagat ggagaaggca 1020gctgtaatcc agtgactgtt
gatggagcag acggagtaaa ggggttttca tacagatatg 1080gtaatggtgt
ttggatagga aggactaaaa gtaacagact cagaaaggga tttgagatga
1140tttgggatcc taatggatgg acagataccg acagtgattt ctctgtgaaa
caggatgtcg 1200tggcaatgac tgattggtca gggtacagcg gaagtttcgt
tcaacatcct gagctaacag 1260gattggactg tatgagacct tgcttctggg
ttgaattaat cagagggcga cctagagaaa 1320atacaacaat ctggactagt
gggagcagca tttctttttg tggcgtaaat agcgatactg 1380caaactggtc
ttggccagac ggtgccgagt tgccattcac cattgacaag tagtccgttg
1440aaaaaaaact ccttgtttct act 1463151689DNAinfluenza A virus
15aaatgaaagc aaaactacta gtcctgttgt gtgcatttac agctacatat gcagacacaa
60tatgtatagg ctaccatgcg aacaactcaa ccgacactgt tgacacagta cttgagaaga
120acgtgacagt gacacactct gtcaacctac ttgaggacag tcacaacgga
aaactatgcc 180gactaaaagg aacagcccca ctacaattgg gtaattgcag
cgttgccgga tggatcttag 240gaaacccaga atgcgaatca ctgttttcta
aggaatcatg gtcctacatt gcagaaacac 300caaaccctga gaatggaaca
tgttacccag ggtatttcgc cgactatgag gaactgaggg 360agcaattgag
ctcagtatca tcattcgaga gattcgaaat attccccaag gaaagctcat
420ggcccaaaca caccgtaacc aaaggagtga cggcatcatg ctcccataat
gggaaaagca 480gtttttacaa aaatttgcta tggctgacgg aaaagaatgg
cttgtaccca aatctgagca 540agtcctatgt aaacaacaag gagaaagaag
tccttgtact atggggtgtt catcacccgt 600ctaacatagg ggaccaaagg
gccatctatc atacagaaaa tgcttatgtc tctgtagtgt 660cttcacatta
tagcagaaga ttcaccccag aaatagcaaa aagacccaaa gtaagaggtc
720aagaagggag aattaactac tactggactc tgctggaacc cggggacaca
ataatatttg 780aggcaaatgg aaatctaata gcgccatggt acgctttcgc
actgagtaga ggctttgggt 840caggaatcat cacctcaacc gcatcaatgg
gtgaatgtga cgctaagtgt caaacacccc 900aaggagctat aaacagtagt
cttcctttcc agaatgtaca cccagtcaca ataggagagt 960gtcccaagta
tgtcaggagt acaaaattaa ggatggttac aggactaaga aacatcccat
1020ccattcaatc tagaggtttg tttggagcca ttgccggttt cattgaaggg
gggtggactg 1080gaatgataga tggatggtat ggttatcatc atcagaatga
acaaggatct ggctatgctg 1140cagaccaaaa aagcacacaa aatgccattg
atgggattac aaacaaggtg aattctgtaa 1200tcgagaaaat gaacactcaa
ttcacagctg taggcaaaga attcaacaaa ttagagagaa 1260ggatggaaaa
cttaaataag aaagttgatg atggatttct ggacatttgg acatataatg
1320cagagttgtt ggttctcctg gaaaatggaa ggactttggg ttttcatgac
tcaaatgtga 1380agaatctgta tgagaaagta aaaaaccaat tgaagaataa
tgccaaagaa atcgggaacg 1440ggtgttttga attctatcac aagtgtaaca
atgaatgcat ggaaagtgtg aaaaatggaa 1500cttatgacta tccaaaatat
tccgaagaat caaagttaaa cagggaaaaa attgatggag 1560tgaaattgga
atcaatggga gtctatcaga ttctggcgat ctactcaact gtcgccagtt
1620cactggtgct tttggtctcc ctgggggcaa tcagtttctg gatgtgttct
aatgggtctt 1680tgcagtgta 1689161447DNAinfluenza A virus
16agcaaaagca ggagtttaaa atgaatccaa atcaaaaaat aataaccatt ggatcaatca
60gtattgcaat tggaataatt agtctgatat tgcaaatagg aaatattatt tcaatatggg
120ctagccactc aatccaaact ggaagtcaaa accacactgg aatatgcaac
caaagaatca 180ttacatatga aaatagcacc tgggtaaatc aaacatatgt
taatattaac aacactaatg 240ttgttgctgg aaaggacaaa acctcaatga
cattggccgg caattcatct ctttgcccta 300tccgtggatg ggctatatac
acaaaagaca acagcataag aattggttcc aaaggagatg 360tttttgtcat
aagagagcct tttatatcat gttctcactt ggaatgcaga accttttttc
420tgacccaagg tgctctatta aatgacaagc attcaaatgg gaccgttaag
gacagaagcc 480cttatagggc cttaatgagc tgtcctctag gtgaagctcc
gtctccatac aattcaagat 540ttgaatcagt tgcttggtca gcaagcgcat
gccatgatgg cttgggctgg ctaacaatcg 600gaatttctgg tccagataat
ggggcagtgg ctgtactaaa atacaacggc ataataactg 660aaaccattaa
aagttggaag aagcgaatat taagaacaca agagtctgaa tgtgtctgta
720tgaacggttc atgttttacc ataatgaccg atggcccgag taatggggcc
gcatcgtaca 780gaatcttcaa aatcgagaag gggagagtta ctaaatcaat
agagttggat gcacccaatt 840atcattacga ggaatgttca tgttacccag
acaccggcac agtgatgtgt gtgtgcaggg 900acaattggca cggttcaaat
cgaccttggg tgtcttttaa tcaaaacctg gattatcaaa 960taggatacat
ctgcagtggg gtgttcggtg acaatccgcg tcccaaagat ggagaaggca
1020gctgtaatcc agtgactgtt gatggagcag acggagtaaa ggggttttca
tacagatatg 1080gtaatggtgt ttggatagga aggactaaaa gtaacagact
cagaaaggga tttgagatga 1140tttgggatcc taatggatgg acagataccg
acagtgattt ctcaatgaaa caggatatcg 1200tggcaatgac tgattggtca
gggtacagcg gaagttttgt tcaacatcct gagctaacag 1260gattggactg
tatgagacct tgcttttggg ttgaattagt cagagggcta cctagagaaa
1320atacaacaat ctggactagt gggagcagca tttctttttg tggcgtaaat
agcgatactg 1380caaactggtc ttggccagac ggtgccgagt tgccattcac
cattgacaag tagtccgttg 1440aaaaaaa 1447171775DNAinfluenza A virus
17agcaaaagca ggggaaaata aaaacaacca aaatgaaagc aaaactacta gtcctgttat
60gtacatttac agctacatat gcagacacaa tatgtatagg ctaccatgcc aacaactcaa
120ccgacactgt tgacacagta cttgagaaga atgtgacagt gacacactct
gtcaacctac 180ttgaggacag tcacaatgga aaactatgtc tactaaaagg
aatagcccca ctacaattgg 240gtaattgcag cgttgccgga tggatcttag
gaaacccaga atgcgaatca ctgatttcta 300aggaatcatg gtcctacatt
gtagagacac caaaccctga gaatggaaca tgttacccag 360ggtatttcgc
cgactatgag gaactgaggg agcaattgag ttcagtatca tcatttgaga
420gattcgaaat attccccaaa gaaagctcat ggcccaaaca caccgtaaca
ggagtaacgg 480catcatgctc ccataatggg aaaagcagtt tttacagaaa
tttgctatgg ctgacggaga 540agaatggctt gtacccaaat ctgagcaatt
cctatgtgaa caacaaagag aaagaagtcc 600ttgtactatg gggtgttcat
cacccatcta acatagggga ccaaagggcc atctatcata 660cagaaaacgc
ttatgtctct gtagtgtctt cacattatag cagaagattc accccagaaa
720tagcaaaaag acccaaagta agaggtcagg aaggaagaat caactactac
tggactctgc 780tggaacccgg ggacacaata atatttgagg caaatggaaa
tctaatagcg ccatggtatg 840ctttcgcact gagtagaggc tttgggtcag
gaatcatcac ctcaaatgca ccaatgaatg 900aatgtgatgc gaagtgtcaa
acacctcagg gagctataaa cagtagtctt cctttccaga 960atgtacaccc
agtcacaata ggagagtgtc caaagtatgt caggagtaca aaattaagga
1020tggttacagg actaaggaat atcccatcca ttcaatccag aggtttgttt
ggagccattg 1080ccggtttcat tgaagggggg tggactggaa tgatggatgg
gtggtatggt tatcatcatc 1140agaatgagca aggatctggc tatgctgcag
atcaaaaaag cacacaaaat gccattaacg 1200ggattacaaa taaggtgaat
tctgtaattg agaaaatgaa cactcaattc acagctgtgg 1260gcaaagaatt
caacaaatta gaaagaagga tggaaaactt aaataaaaaa gttgatgatg
1320gatttctaga catttggaca tataatgcag aattgttggt tctactggaa
aatgaaagga 1380ctttggattt ccatgactca aatgtgaaga atctgtatga
gaaagtgaaa agccaattaa 1440agaataatgc caaagaaata gggaacgggt
gttttgaatt ctatcacaag tgtaacaatg 1500aatgcatgga aagtgtgaaa
aatggaactt atgactatcc aaaatattcc gaagaatcaa 1560agttaaacag
ggagaaaatt gatggagtga aattggaatc aatgggagtc tatcagattc
1620tggcgatcta ctcaactgtc gccagttcac tggttctttt ggtctccctg
ggggcaatca 1680gcttctggat gtgttccaat gggtctttgc agtgtagaat
atgcatctga gaccagaatt 1740tcagaaatat aagaaaaaac acccttgttt ctact
1775181463DNAinfluenza A virus 18agcaaaagca ggagtttaaa atgaatccaa
atcaaaaaat aataaccatt ggatcaatca 60gtatagtaat cgggataatt agtctaatgt
tgcaaatagg aaatattatt tcaatatggg 120ctagtcactc aatccaaact
ggaagtcaaa accacactgg aatatgcaac caaagaatca 180tcacatatga
aaatagcacc tgggtgaatc acacatatgt taatattaac aacactaatg
240ttgttgctgg aaaggacaaa acttcagtga cattggccgg caattcatca
ctttgttcta 300tcagtggatg ggctatatac acaaaagaca acagcataag
aattggttcc aaaggagatg 360tttttgtcat aagagagcct tttatatcat
gttctcactt ggaatgcaga accttttttc 420tgacccaagg tgctctatta
aatgacaaac attcaaatgg gaccgttaag gacagaagtc 480cttatagggc
cttaatgagc tgtcctctag gcgaagctcc gtctccatat aattcaaagt
540ttgaatcagt tgcttggtca gcaagcgcat gtcatgatgg catgggctgg
ttaacaatcg 600gaatttctgg tccagataat ggagcagtgg ctgtactaaa
atacaacggc ataataactg 660aaaccataaa aagttggaaa aagcgaatat
taagaacaca agagtctgaa tgtgtctgtg 720tgaacgggtc atgttttacc
ataatgaccg atggcccgag taatggggcc gcctcgtaca 780aaatcttcaa
gattgagaag gggaaggtta ctaaatcaat agagttgaat gcacccaatt
840ctcattatga ggaatgttcc tgttacccag acactggcac agtgatgtgt
gtatgcaggg 900acaattggca cggttcaaat cgaccttggg tgtcttttaa
tcaaaacctg gattatcaaa 960taggatacat ctgcagtggg gtgttcggtg
acaatccgcg tcccaaagat ggagagggca 1020gctgtaatcc agtgactgtt
gatggagcag acggagtaaa ggggttttca tacagatatg 1080gtaatggtgt
ttggatagga aggactaaaa gtaacagact cagaaaggga tttgagatga
1140tttgggatcc taatggatgg acagataccg acagtgattt ctcagtgaaa
caggatgttg 1200tggcaatgac tgattggtca gggtacagcg gaagtttcgt
tcaacatcct gagctaacag 1260gattggactg tataagacct tgcttctggg
ttgaattagt cagaggacgg cctagagaaa 1320atacaacaat ctggactagt
gggagcagca tttctttttg tggcgtaaat agtgatactg 1380caaactggtc
ttggccagac ggtgctgagt tgccattcac cattgacaag tagtccgttg
1440aaaaaaaact ccttgtttct act 1463191775DNAinfluenza A virus
19agcaaaagca ggggaaaata aaaacaacca aaatgaaagc aaaactactg gtcctgttat
60gtacatttac agctacatat gcagacacaa
tatgtatagg ctaccatgcc aacaactcaa 120ccgacactgt tgacacagta
cttgagaaga atgtgacagt gacacactct gtcaacctac 180ttgaggacag
tcacaatgga aaactatgtc tactaaaagg aatagcccca ctacaattgg
240gtaattgcag cgttgccgga tggatcttag gaaacccaga atgcgaatta
ctgatttcca 300aggaatcatg gtcctacatt gtagaaacac caaatcctga
gaatggaaca tgttacccag 360ggtatttcgc cgactatgag gaactgaggg
agcaattgag ttcagtatct tcatttgaga 420gattcgaaat attccccaaa
gaaagctcat ggcccaaaca caccgtaacc ggagtatcag 480catcatgctc
ccataatggg aaaaacagtt tttacagaaa tttgctatgg ctgacgggga
540agaatggttt gtacccaaac ctgagcaagt cctatgtaaa caacaaagag
aaagaagtcc 600ttgtactatg gggtgttcat cacccgccta acatagggga
ccaaagggcc ctctatcata 660cagaaaatgc ttatgtctct gtagtgtctt
cacattatag cagaagattc accccagaaa 720tagccaaaag acccaaagta
agagatcagg aaggaagaat caactactac tggactctgc 780tggaacctgg
ggatacaata atatttgagg caaatggaaa tctaatagcg ccatggtatg
840cttttgcact gagtagaggc tttggatcag gaatcatcac ctcaaatgca
ccaatggatg 900aatgtgatgc gaagtgtcaa acacctcagg gagctataaa
cagcagtctt cctttccaga 960atgtacaccc agtcacaata ggagagtgtc
caaagtatgt caggagtgca aaattgagga 1020tggttacagg actaaggaac
atcccatcca ttcaatccag aggtttgttt ggagccattg 1080ccggtttcat
tgaagggggg tggactggaa tggtagatgg gtggtatggt tatcatcatc
1140agaatgagca aggatctggc tatgctgcag atcaaaaaag tacacaaaat
gccattaacg 1200ggattacaaa caaggtgaat tctgtaattg agaaaatgaa
cactcaattc acagctgtgg 1260gcaaagaatt caacaaattg gaaagaagga
tggaaaactt aaataaaaaa gttgatgatg 1320ggtttctaga catttggaca
tataatgcag aattgttggt tctactggaa aatgaaagga 1380ctttggattt
ccatgactcc aatgtgaaga atctgtatga gaaagtaaaa agccaattaa
1440agaataatgc caaagaaata ggaaacgggt gttttgaatt ctatcacaag
tgtaacaatg 1500aatgcatgga gagtgtgaaa aatggaactt atgactatcc
aaaatattcc gaagaatcaa 1560agttaaacag ggagaaaatt gatggagtga
aattggaatc aatgggagtc tatcagattc 1620tggcgatcta ctcaactgtc
gccagttccc tggttctttt ggtctccctg ggggcaatca 1680gcttctggat
gtgttccaat gggtctttgc agtgtagaat atgcatctga gaccagaatt
1740tcagaagtat aagaaaaaac acccttgttt ctact 1775201463DNAinfluenza A
virus 20agcaaaagca ggagtttaaa atgaatccaa atcaaaaaat aataaccatt
ggatcaatca 60gtatagcaat cggaataatt agtctaatgt tgcaaatagg aaatattatt
tcaatatggg 120ctagtcactc aatccaaact ggaagtcaaa accacactgg
agtatgcaac caaagaatca 180tcacatatga aaacagcacc tgggtgaatc
acacatatgt taatattaac aacactaatg 240ttgttgctgg aaaggacaaa
acttcagtga cattggccgg caattcatct ctttgttcta 300tcagtggatg
ggctatatac acaaaagaca acagcataag aattggctcc aaaggagatg
360tttttgtcat aagagaacct ttcatatcat gttctcactt ggaatgcaga
accttttttc 420tgacccaagg tgctctatta aatgacaaac attcaaatgg
gaccgttaag gacagaagtc 480cttatagggc cttaatgagc tgtcctctag
gtgaagctcc gtccccatac aattcaaagt 540ttgaatcagt tgcatggtca
gcaagcgcat gccatgatgg catgggctgg ttaacaatcg 600gaatttctgg
tccagacaat ggagctgtgg ctgtactaaa atacaacggc ataataactg
660aaaccataaa aagttggaaa aagcgaatat taagaacaca agagtctgaa
tgtgtctgtg 720tgaacgggtc atgtttcacc ataatgaccg atggcccgag
taatggggcc gcctcgtaca 780aaatcttcaa gatcgaaaag gggaaggtta
ctaaatcaat agagttgaat gcacccaatt 840ttcattatga ggaatgttcc
tgttacccag acactggcac agtgatgtgt gtatgcaggg 900acaactggca
tggttcaaat cgaccttggg tgtcttttaa tcaaaacctg gattatcaaa
960taggatacat ctgcagtggg gtgttcggtg acaatccgcg tcccaaagat
ggagagggca 1020gctgtaatcc agtgactgtt gatggagcag acggagtaaa
ggggttttca tacaaatatg 1080gtaatggtgt ttggatagga aggactaaaa
gtaacagact tagaaagggg tttgagatga 1140tttgggatcc taatggatgg
acagataccg acagtgattt ctcagtgaaa caggatgttg 1200tggcaataac
tgattggtca gggtacagcg gaagtttcgt tcaacatcct gagttaacag
1260gattggactg tataagacct tgcttctggg ttgagttagt cagaggactg
cctagagaaa 1320atacaacaat ctggactagt gggagcagca tttctttttg
tggcgtaaat agtgatactg 1380caaactggtc ttggccagac ggtgctgagt
tgccgttcac cattgacaag tagttcgttg 1440aaaaaaaact ccttgtttct act
1463211879DNAinfluenza B virus 21agcagaagca gagcattttc taatatccac
aaaatgaagg caataattgt actactcatg 60gtagtaacat ccaacgcaga tcgaatctgc
actgggataa catcttcaaa ctcacctcat 120gtggtcaaaa cagctactca
aggggaagtc aatgtgactg gtgtgatacc actgacaaca 180acaccaacaa
aatctcattt tgcaaatctc aaaggaacaa agaccagagg gaaactatgc
240ccaaactgtc tcaactgcac agatctggat gtggccttgg gcagaccaat
gtgtataggg 300atcacacctt cggcaaaagc ttcaatactc cacgaagtca
gacctgttac atccgggtgc 360tttcctataa tgcacgacag aacaaaaatc
agacagctac ccaatcttct cagaggatat 420gaacatatca gattatcaac
ccataacgtt atcaacgcag aaagggcacc aggaggaccc 480tacagacttg
gaacctcagg atcttgccct aacgttacca gtagaagcgg attcttcgca
540acaatggctt gggctgtccc aagggacaac aaaacagcaa cgaacccact
aacagtagaa 600gtaccataca tttgtacaaa aggagaagac caaattactg
tttgggggtt ccattctgat 660aacaaaatcc aaatgaaaaa cctctatgga
gactcaaatc ctcaaaagtt cacctcatct 720gccaatggaa taaccacaca
ttatgtttct cagattggtg gcttcccaaa tcaaacagaa 780gacggagggc
taccacaaag cggcagaatt gttgttgatt acatggtgca aaaacctggg
840aaaacaggaa caattgtcta tcaaagaggt gttttgttgc ctcaaaaggt
gtggtgtgca 900agtggcagga gcaaggtaat aaaagggtcc ttgcctttaa
ttggtgaagc agattgcctt 960cacgaaaaat acggtggatt aaacaaaagc
aagccttact acacaggaga acatgcaaaa 1020gccataggaa attgcccaat
atgggtgaaa acacctttaa agcttgccaa tggaaccaaa 1080tatagacctc
ccgcaaaact attaaaggaa aagggtttct tcggagctat tgctggtttc
1140ttagaaggag gatgggaagg aatgattgca ggttggcacg gatacacatc
tcatggagca 1200catggggtgg cagtggcagc agaccttaag agtacgcaag
aagccataaa caagataaca 1260aaaaatctca attctttgag tgagctagaa
gtaaagaatc ttcaaagact aagtggtgcc 1320atggatgaac tccacaacga
aatactcgag ctggatgaga aagtggatga tctcagagct 1380gacacaataa
gctcgcaaat agagcttgca gtcttgcttt ccaatgaagg aataataaac
1440agtgaagatg agcatctatt ggcacttgag agaaaactaa agaaaatgct
gggtccctct 1500gctgtagaca tagggaatgg atgcttcgaa accaaacaca
agtgcaacca gacctgctta 1560gacaggatag ctgctggcac ctttaatgca
ggagaatttt ctcttcccac ttttgattca 1620ctgaatatta ctgctgcatc
tttaaatgat gatggattgg ataatcatac tatactgctc 1680tactactcaa
ctgcggcttc tagtttggct gtaacattga tgatagctat ttttattgtt
1740tatatggtct ccagagacaa tgtttcttgc tccatctgtc tatagggaaa
attgagccct 1800gtattttcct ttattgtggt gcttgtttgc ttgttgccat
tacagagaaa cgttattgaa 1860aaatgctctt gttactact
1879221554DNAinfluenza B virus 22agcagaagca gagcatcttc tcaaaactga
agtaaagagg ccaaaaatga acaatgctac 60cttcaactat acaaacgtta accctatttc
tcacatcagg gggagtgtta ttatcactat 120atgtgtcagc cttactgtca
tacttattgt attcggatat attgctaaaa ttttcaccaa 180aaataattgc
accaacaacg tcgttggact gcgcgaacgc atcaaatgtt caggctgtga
240accattctgc aacaaaagag atgaaattcc ttcccccaga accggagtgg
acataccccc 300gtttatcttg ccagggttca accttccaga aagcactctt
aattagccct catagatttg 360gagaagccaa aggaaactca gctcccttga
taataaggga accttttatt gcttgtggac 420caaaggagtg caaacacttt
gctctaaccc attatgcagc tcaaccaggg ggatactaca 480atggaacaag
agaggacaga aacaagctga ggcatctgat ttcagtcaac ttaggcaaaa
540tcccaactgt agaaaactcc attttccata tggcagcttg gagtggatcc
gcatgccatg 600atggtagaga atggacatat atcggagttg atggtcctga
cagtaatgca ttgatcaaaa 660taaaatatgg agaagcatac actgacacat
accattccta tgcaaacaac atcctaagaa 720cacaagaaag tgcctgcaat
tgcatcgggg gagattgtta tcttatgata actgatggct 780cagcttcagg
aattagtaaa tgcagattcc ttaagatccg agagggtcga ataataaaag
840aaatatttcc aacaggaagg gtagagcaca ctgaagaatg cacatgcgga
tttgccagca 900acaaaaccat agaatgtgcc tgtagagata acagttacac
agcaaaaaga ccctttgtca 960aattaaatgt ggagactgat acagctgaaa
taagattgat gtgcacagag acttatttgg 1020acacccccag accagatgat
ggaagcataa cagggccttg cgaatctaat ggggacaaag 1080ggagtggagg
tgtcaaggga ggatttgttc atcaaagaat ggcatccaag attggaagat
1140ggtactcccg aacgatgtct aaaactaaaa gaatggggat ggaactgtat
gtcaagtatg 1200atggagaccc atggactgac agtgacgccc ttgctcctag
tggagtaatg gtctcaatgg 1260aagaacctgg ttggtactct ttcggcttcg
aaataaaaga taagaaatgt gatgtcccct 1320gtattgggat agagatggta
catgatggtg gaaaaaggac ttggcactca gcagcaacag 1380ccatttactg
tttaatgggc tcaggacagt tgctatggga cactgtcaca ggtgttaata
1440tggctctgta atggaggaat ggttgaatct gttctaaacc ctttgttcct
attttatttg 1500aacaattgtc cttactggac ttaattgttt ctgaaaaatg
ctcttgttac tact 1554231881DNAinfluenza B virus 23agcagaagca
gagcattttc taatatccac aaaatgaagg caataattgt actactcatg 60gtagtaacat
ccaatgcaga tcgaatctgc actgggataa catcgtcaaa ctcacctcat
120gtggtcaaaa cagctactca aggggaggtc aatgtgactg gtgtgatacc
actgacaaca 180acaccaacaa aatctcattt tgcaaatctc aaaggaacaa
agaccagagg gaaactatgc 240ccaacctgtc tcaactgcac agatctggat
gtggccttag gcagaccaat gtgtgtgggg 300gtcacacctt cggcaaaagc
ttcaatactc cacgaagtca ggcctgttac atccggatgc 360tttcctataa
tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat
420gaaaaaatca gattatcaac ccaaatcgtt atcaacgcag aaaaggcacc
aggaggaccc 480tacagacttg gaacctcagg atcttgccct aacgctacca
gtagaagcgg atttttcgca 540acaatggctt gggctgtccc aaaggacaac
aacaaaacag caacgaatcc actaacagta 600gaagtaccac acatctgtac
aaaagaagaa gaccaaatta ctgtttgggg gttccattct 660gatgacaaaa
cccaaatgaa aaacctctat ggagactcaa atcctcaaaa gttcacctca
720tctgctaatg gagtaaccac acattatgtt tctcagattg gcggcttccc
ggatcaaaca 780gaagacggag ggctaccaca aagcggcaga attgttgttg
attacatggt gcaaaaacct 840gggaaaacag gaacaattgt ctatcaaaga
ggtattttgt tgcctcaaaa ggtgtggtgc 900gcgagtggca ggagcaaagt
aataaaaggg tccttgcctt taattggtga agcagattgc 960cttcacgaaa
aatacggtgg attaaacaaa agcaagcctt actacacagg agaacatgca
1020aaagccatag gaaattgccc aatatgggtg aaaacacctt tgaagcttgc
caatggaacc 1080aaatatagac ctcctgcaaa actattaaag gaaaggggtt
tcttcggagc tattgctggt 1140ttcttagaag gaggatggga aggaatgatt
gcaggttggc acggatacac atctcacgga 1200gcacatggag tggcagtggc
agcagacctt aagagtacgc aagaagccat aaacaagata 1260acaaaaaatc
tcaattcttt gagtgagcta gaagtaaaga atcttcaaag actaagtggt
1320gccatggatg aactccacaa cgaaatactc gagctggatg agaaagtgga
tgatctcaga 1380gctgacacaa taagctcaca aatagaactt gcagtcttgc
tttccaacga aggaataata 1440aacagtgaag atgagcatct attggcactt
gagagaaaac taaagaaaat gctgggtccc 1500tctgctgtag acatagggaa
tggatgcttc gaaaccaaac acaagtgcaa ccagacctgc 1560ttagacagga
tagctgctgg cacctttaat gcaggagaat tttctcttcc cacttttgat
1620tcactgaata ttactgctgc atctttaaat gatgatggat tggataacca
tactatactg 1680ctctactact caactgctgc ttctagtttg gctgtaacat
tgatgatagc tatttttatt 1740gtttatatga tctccagaga caatgtttct
tgctccatct gtctataggg aaattaagcc 1800ctgtattttc ctttattgta
gtgcttgttt gcttgttatc attacaaaga aacgttattg 1860aaaaatgctc
ttgttactac t 1881241557DNAinfluenza B virus 24agcagaagca gagcatcttc
tcaaaactga ggcaaatagg ccaaaaatga acaatgctac 60cttcaactat acaaacgtta
accctatttc tcacatcagg gggagtgtta ttatcactat 120atgtgtcagc
ttcactgtca tacttactat attcggatat attgctaaaa ttttcaccaa
180cagaaataac tgcaccaaca atgccattga attgtgcaaa cgcatcaaat
gttcaggctg 240tgaaccgttc tgcaacaaaa ggggtgacac ttcctctccc
agaaccggag tggacatacc 300ctcgtttatc ttgcccgggc tcaacctttc
agaaagcact cctaattagc cctcatagat 360tcggagaaac caaaggaaac
tcagctccct tgataataag ggaacctttt attgcttgtg 420gaccaaagga
atgcagacac tttgctctaa cccattatgc agcccaacca gggggatact
480acaatggaac aagagaagac agaaacaagc tgaggcatct aatttcagtc
aaattgggca 540aaatcccaac agtagaaaac tccattttcc acatggcagc
ttggagcggg tccgcatgcc 600atgatggtag agaatggaca tatatcggag
ttgatggccc tgacagtaat gcattgctca 660aaataaaata tggagaagca
tatactgaca cataccattc ctatgcaaac aacatcctaa 720gaacacaaga
aagtgcctgc aattgcatcg ggggagattg ttatcttatg ataactgatg
780gctcagcttc agggattagt gaatgcagat ttcttaagat tcgagagggc
cgaataataa 840aagaaatatt tccaacagga agagtagaac atactgaaga
atgcacatgc ggatttgcca 900gcaataaaac catagaatgt gcctgtagag
ataacagtta cacagcaaaa agaccctttg 960tcaaattaaa tgtggagact
gatacagcag aaataagatt gatgtgcaca gagacttact 1020tggacacccc
cagaccagat gatggaagca taacagggcc ttgtgaatct aatggggata
1080aagggagtgg aggcatcaag ggaggatttg ttcatcaaag aatggcatcc
aagattggaa 1140ggtggtactc tcgaacgatg tctaaaacta aaaggatggg
gatgggactg tatgtcaagt 1200atgatggaga cccatggatt gacagtgatg
cccttactct tagcggagta atggtttcaa 1260tggaagaacc tggttggtat
tcctttggct tcgaaataaa agataagaaa tgtgatgtcc 1320cctgtattgg
gatagagatg gtacatgatg gtggaaagaa gacttggcac tcagcagcaa
1380cagccattta ctgtttaatg ggctcaggac aactgctatg ggacactgtc
acaggcgttg 1440atatggctct gtaatggagg aatggttgag tctgttctaa
accctttgtt cctattttgt 1500ttgaacaatt gtccttactg aacttaattg
tttctgaaaa atgctcttgt tactact 1557251882DNAinfluenza B virus
25agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg
60gtagtaacat ccaatgcaga tcgaatctgc actgggataa catcgtcaaa ctcacctcat
120gtggtcaaaa cagctactca aggggaggtc aatgtgactg gtgcgatacc
attgacaaca 180acaccaacaa aatctcattt tgcaaatctc aaaggaacaa
agaccagagg gaaactatgc 240ccaacctgtc tcaactgcac agatctggat
gtggccttgg gcagaccaat gtgtgtgggg 300atcacacctt cggcaaaagc
ttcaatactc cacgaagtca gacctgttac atccggatgc 360tttcctataa
tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat
420gaaaaaatca gattatcaac ccaaaacgtt atcaacgcag aaaaggcacc
aggaggaccc 480tacagacttg gaacttcagg atcttgccct aacgctacca
gtaaaagcgg atttttcgca 540acaatggctt gggctgtccc aagggacaac
aacaaaacag caacgaatcc actaacagta 600gaagtaccac acatctgtac
aaaagaagaa gaccaaatta ctgtttgggg gttccattct 660gatgacaaaa
cccaaatgaa aaacctctat ggagactcaa atcctcaaaa gttcacctca
720tctgctaatg gaataaccac acattatgtt tctcagattg gcggcttccc
ggaccaaaca 780gaagacggag ggctaccaca aagcggcaga attgttgttg
attacatggt gcaaaaacct 840gggaaaacag gaacaattgt ctatcaaaga
gggatcttgt tgcctcaaaa ggtgtggtgc 900gcgagtggca ggagcaaagt
aataaaaggg tccttgcctt taattggtga agcagattgc 960cttcacgaaa
aatacggtgg attaaacaaa agcaagcctt actacacagg agaacatgca
1020aaagccatag gaaattgccc aatatgggtg aaaacacctt tgaagcttgc
caatggaacc 1080aagtatagac ctcctgcaaa actattaaag gaaaggggtt
tcttcggagc tattgctggt 1140ttcttagaag gaggatggga aggaatgatt
gcaggttggc acggatacac atctcacgga 1200gcacacggag tggcagtggc
agcagacctt aagagtacgc aagaagccat aaacaagata 1260acaaaaaatc
tcaattcttt gagtgagtta gaagtaaaga accttcaaag actaagtggt
1320gccatggatg aactccataa cgaaatactc gagctggatg agaaagtgga
tgatctcaga 1380gctgacacaa taagctcaca aatagaactt gcagtcttgc
tttccaacga aggaataata 1440aacagtgaag atgagcatct attggcactt
gagagaaaac taaagaagat gctgggtccc 1500tctgctatag acatagggaa
tggatgcttc gaaaccaaac acaagtgcaa ccagacctgc 1560ttagacagga
tagctgctgg cacctttaat gcaggagaat tttctcttcc cacttttgat
1620tcactgaaca ttactgctgc atctttaaat gatgatggat tggataacca
tactatactg 1680ctctactact caactgctgc ttctagtttg gctgtaacat
tgatgatagc tatttttatt 1740gtttatatga tctccagaga caatgtttct
tgctccatct gtctataagg aaaattaagc 1800cctgtatttt cctttattgt
agtgcttgtt tgcttgttat cattacaaag aaacgttatt 1860gaaaaatgct
cttgttacta ct 1882261557DNAinfluenza B virus 26agcagaagca
gagcatcttc tcaaaactga ggcaaatagg ccaaaaatga acaatgctac 60cctcaactat
acaaacgtta accctattcc tcacatcagg gggagtgtta ttatcactat
120atgtgtcagc ttcactgtca tacttactat attcggatat attgctaaaa
ttttcaccaa 180cagaaataac tgcaccagca atgcccttgg attgtgcaaa
cgcatcaaat gttcaggctg 240tgaaccgttc tgcaacaaaa ggggtgacac
ttcttctccc agaaccggag tggacatacc 300cgcgtttatc ttgcccgggc
tcaacctttc agaaagcact cctaattagc cctcatagat 360tcggagaaac
caaaggaaac tcagctccct tgataataag ggaacctttt attgcttgtg
420gaccaaagga atgcaaacac tttgctctaa cccattatgc agcccaacca
gggggatact 480acaatggaac aagagaagac agaaacaagc taaggcatct
aatttcagtc aaatttggta 540aaatcccaac agtagaaaac tccattttcc
acatggcagc atggagcggg tccgcatgcc 600atgatggtaa agaatggaca
tatatcggag ttgatggccc tgacagtaat gcattgctca 660aaataaaata
tggagaagca tatactgaca cataccattc ctatgcaaac aacatcctaa
720gaacacaaga aagtgcctgc aattgcatcg ggggaaattg ttatcttatg
ataactgatg 780gctcagcttc aggtattagt gagtgcagat ttcttaagat
tcgagagggc cgaataataa 840aagaaatatt tccaacagga agagtaaaac
atactgaaga atgcacatgc ggatttgcca 900gcaataaaac catagaatgt
gcctgtagag ataacagtta cacagcaaaa agaccctttg 960tcaaattaaa
tgtggagact gatacagcag aaataagatt gatgtgcaca gagacttatt
1020tggacacccc cagaccagat gatggaagca taacagggcc ttgtgaatct
aatggggata 1080aagggagtgg aggcatcaag ggaggatttg ttcatcaaag
aatggcatcc aagattggaa 1140ggtggtactc tcgaacaatg tctaaaacta
aaaggatggg gatgggactg tatgtcaagt 1200atgatggaga cccatggact
gacagtgatg cccttgctct tagtggagta atggtttcaa 1260tggaagaacc
tggttggtac tcctttggct tcgaaataaa agataagaaa tgtgatgtcc
1320cctgtattgg gatagagatg gtacatgatg gtggaaagga gacttggcac
tcagcagcaa 1380cagccattta ctgtttaatg ggctcaggac aactgctatg
ggacactgtc acaggtgttg 1440atatggctct gtaatggagg aatggttgag
tctgttctaa accctttgtt cctattttgt 1500ttgaacaatt gtccttactg
aacttaattg tttctgaaaa atgctcttgt tactact 1557271879DNAinfluenza B
virus 27agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt
actactcatg 60gtagtaacat ccaacgcaga tcgaatctgc actgggataa catcttcaaa
ctcacctcat 120gtggtcaaaa cagctactca aggggaagtc aatgtgactg
gtgtgatacc actgacaaca 180acaccaacaa aatctcattt tgcaaatctc
aaaggaacaa agaccagagg gaaactatgc 240ccaaactgtc tcaactgcac
agatctggat gtggccttgg gcagaccaat gtgtataggg 300atcacacctt
cggcaaaagc ttcaatactc cacgaagtca gacctgttac atccgggtgc
360tttcctataa tgcacgacag aacaaaaatc agacagctac ccaatcttct
cagaggatat 420gaacatatca gattatcaac ccataacgtt atcaacgcag
aaagggcacc aggaggaccc 480tacagacttg gaacctcagg atcttgccct
aacgttacca gtagaagcgg attcttcgca 540acaatggctt gggctgtccc
aagggacaac aaaacagcaa cgaacccact aacagtagaa 600gtaccataca
tttgtacaaa aggagaagac caaattactg tttgggggtt ccattctgat
660aacaaaatcc aaatgaaaaa cctctatgga gactcaaatc ctcaaaagtt
cacctcatct 720gccaatggaa taaccacaca ttatgtttct cagattggtg
gcttcccaaa tcaaacagaa 780gacggagggc taccacaaag cggcagaatt
gttgttgatt acatggtgca aaaacctggg 840aaaacaggaa caattgtcta
tcaaagaggt gttttgttgc ctcaaaaggt gtggtgtgca 900agtggcagga
gcaaggtaat aaaagggtcc ttgcctttaa ttggtgaagc agattgcctt
960cacgaaaaat acggtggatt aaacaaaagc aagccttact acacaggaga
acatgcaaaa 1020gccataggaa attgcccaat atgggtgaaa acacctttaa
agcttgccaa tggaaccaaa 1080tatagacctc ccgcaaaact attaaaggaa
aagggtttct tcggagctat tgctggtttc 1140ttagaaggag gatgggaagg
aatgattgca
ggttggcacg gatacacatc tcatggagca 1200catggggtgg cagtggcagc
agaccttaag agtacgcaag aagccataaa caagataaca 1260aaaaatctca
attctttgag tgagctagaa gtaaagaatc ttcaaagact aagtggtgcc
1320atggatgaac tccacaacga aatactcgag ctggatgaga aagtggatga
tctcagagct 1380gacacaataa gctcgcaaat agagcttgca gtcttgcttt
ccaatgaagg aataataaac 1440agtgaagatg agcatctatt ggcacttgag
agaaaactaa agaaaatgct gggtccctct 1500gctgtagaca tagggaatgg
atgcttcgaa accaaacaca agtgcaacca gacctgctta 1560gacaggatag
ctgctggcac ctttaatgca ggagaatttt ctcttcccac ttttgattca
1620ctgaatatta ctgctgcatc tttaaatgat gatggattgg ataatcatac
tatactgctc 1680tactactcaa ctgcggcttc tagtttggct gtaacattga
tgatagctat ttttattgtt 1740tatatggtct ccagagacaa tgtttcttgc
tccatctgtc tatagggaaa attgagccct 1800gtattttcct ttattgtggt
gcttgtttgc ttgttgccat tacagagaaa cgttattgaa 1860aaatgctctt
gttactact 1879281554DNAinfluenza B virus 28agcagaagca gagcatcttc
tcaaaactga agtaaagagg ccaaaaatga acaatgctac 60cttcaactat acaaacgtta
accctatttc tcacatcagg gggagtgtta ttatcactat 120atgtgtcagc
cttactgtca tacttattgt attcggatat attgctaaaa ttttcaccaa
180aaataattgc accaacaacg tcgttggact gcgcgaacgc atcaaatgtt
caggctgtga 240accattctgc aacaaaagag atgaaattcc ttcccccaga
accggagtgg acataccccc 300gtttatcttg ccagggttca accttccaga
aagcactctt aattagccct catagatttg 360gagaagccaa aggaaactca
gctcccttga taataaggga accttttatt gcttgtggac 420caaaggagtg
caaacacttt gctctaaccc attatgcagc tcaaccaggg ggatactaca
480atggaacaag agaggacaga aacaagctga ggcatctgat ttcagtcaac
ttaggcaaaa 540tcccaactgt agaaaactcc attttccata tggcagcttg
gagtggatcc gcatgccatg 600atggtagaga atggacatat atcggagttg
atggtcctga cagtaatgca ttgatcaaaa 660taaaatatgg agaagcatac
actgacacat accattccta tgcaaacaac atcctaagaa 720cacaagaaag
tgcctgcaat tgcatcgggg gagattgtta tcttatgata actgatggct
780cagcttcagg aattagtaaa tgcagattcc ttaagatccg agagggtcga
ataataaaag 840aaatatttcc aacaggaagg gtagagcaca ctgaagaatg
cacatgcgga tttgccagca 900acaaaaccat agaatgtgcc tgtagagata
acagttacac agcaaaaaga ccctttgtca 960aattaaatgt ggagactgat
acagctgaaa taagattgat gtgcacagag acttatttgg 1020acacccccag
accagatgat ggaagcataa cagggccttg cgaatctaat ggggacaaag
1080ggagtggagg tgtcaaggga ggatttgttc atcaaagaat ggcatccaag
attggaagat 1140ggtactcccg aacgatgtct aaaactaaaa gaatggggat
ggaactgtat gtcaagtatg 1200atggagaccc atggactgac agtgacgccc
ttgctcctag tggagtaatg gtctcaatgg 1260aagaacctgg ttggtactct
ttcggcttcg aaataaaaga taagaaatgt gatgtcccct 1320gtattgggat
agagatggta catgatggtg gaaaaaggac ttggcactca gcagcaacag
1380ccatttactg tttaatgggc tcaggacagt tgctatggga cactgtcaca
ggtgttaata 1440tggctctgta atggaggaat ggttgaatct gttctaaacc
ctttgttcct attttatttg 1500aacaattgtc cttactggac ttaattgttt
ctgaaaaatg ctcttgttac tact 1554291885DNAinfluenza B virus
29agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg
60gtagtaacat ccaatgcaga tcgaatctgc actggaataa catcgtcaaa ctcaccccat
120gtggtcaaaa ctgctactca aggggaagtc aatgtgactg gtgtgatacc
actgacaaca 180acacccacca aatctcattt tgcaaatctc aaaggaacaa
aaaccagagg gaaactatgc 240ccaaaatgtc tcaactgcac agatctggac
gtggccttgg gcagaccaaa atgcacgggg 300aacatacctt cggcaaaagt
ttcaatactc catgaagtaa gacctgttac atctgggtgc 360tttcctataa
tgcacgacag aacaaaaatt agacagctgc ccaatcttct cagaggatac
420gaacgtatca ggttatcaaa ccataacgtt atcaatgcag aaaaagcacc
aggaggaccc 480tacaaaattg gaacctcagg gtcttgccct aacgttacca
atggaaacgg attcttcgca 540acaatggctt gggctgtccc aaaaaacgaa
aacaacaaaa cagcaacaaa ttcattaaca 600atagaagtac catacatttg
tacagaagga gaagaccaaa ttaccgtttg ggggttccac 660tctgatagcg
aaacccaaat ggcaaaactc tatggagact caaagcctca gaagttcact
720tcatctgcta acggagtgac cacacattac gtttcacaga ttggtggctt
cccaaatcaa 780acagaagacg gaggactacc acaaagtggt agaattgttg
ttgattacat ggtgcaaaaa 840tctggaaaaa caggaacaat tacctatcaa
agaggtattt tattgcctca aaaagtgtgg 900tgcgcaagtg gcaggagcaa
ggtaataaaa ggatccttgc ctttaattgg agaagcagat 960tgcctccacg
aaaaatacgg tggattaaac aaaagcaagc cttactatac aggggaacat
1020gcaaaagcca taggaaattg cccaatatgg gtgaaaacac ccttgaagct
ggccaatgga 1080accaaatata gacctcctgc aaaactatta aaggaaaggg
gtttcttcgg agctattgct 1140ggtttcttag aaggaggatg ggaaggaatg
attgcaggtt ggcacggata cacatcccat 1200ggagcacatg gagtagcagt
ggcagcagac cttaagagta ctcaagaagc cataaacaag 1260atcacaaaaa
atctcaactc tttgagtgag ctggaagtaa agaatcttca aagactaagc
1320ggagccatgg atgaactcca caacgaaata ctagaactag atgagaaagt
ggatgatctc 1380agagctgata caataagctc gcaaatagaa ctcgcagtct
tgctttccaa tgaaggaata 1440ataaacagtg aagatgagca tctcttggcg
cttgaaagaa aactgaagaa aatgctgggc 1500ccctctgctg tagagatagg
gaatggatgc ttcgaaacca aacacaagtg caaccagacc 1560tgcctcgata
gaatagctgc tggcaccttt aatgcaggag aattttctct ccccaccttt
1620gattcactaa atattactgc tgcatcttta aatgacgatg gattggataa
tcatactata 1680ctgctttact actcaactgc tgcttccagt ttggctgtaa
cattgatgat agctatcttt 1740gttgtttata tggtctccag agacaatgtt
tcttgttcca tctgtctata aggaaagtta 1800agccccgtat tttcctttat
tgtagtactt gtttgcttgt tatcattaca aaaaaacgtt 1860attgaaaaat
gctcttgtta ctact 1885301544DNAinfluenza B virus 30agcagagcat
cttctcaaaa ctgaagcaaa taggccaaaa tgaacaatgc taccctcaac 60tatacaaaca
ttaaccctat ttctcacatc agggggagtg ttattatcac tatatgtgtc
120agccttactg tcatacttac tgtattcgga tatattgcta aaattttcac
caacaaaaat 180aattgcacca acaacgtcgt tggactccgc gaacgcatca
aattttcagg ccgtgaacca 240ttctgcaaca aaagagatga catttcttct
cccagaaccg gagtggacat accctcgttt 300atcttgccag ggttcaacct
ttcaaaaagc actcctaatt agccctcata gattcggaga 360agccaaagga
aactcagctc ccttgataat aagggaacct tttattgctt gtggaccaaa
420ggagtgtaaa cactttgctc taacccatta tgcagctcaa ccagggggat
actacaatgg 480aacaagagag gacagaaaca agctgaggca tctgatttca
gtcaacttag gcaaaatacc 540aactgtagaa aactccattt tccacatggc
agcttggagt gggtccgcat gccatgatgg 600tagagagtgg acttatatcg
gagttgatgg ccctgacagt aatgcattga tcaaaataaa 660atatggagaa
gcatacactg acacatacca ttcctatgca aacaacatcc taagaacaca
720agaaagtgcc tgcaactgca tcgggggaga ttgttatctt atgataactg
atggctcagc 780ttcaggaatt agtaaatgca gattccttaa gattcgagag
ggtcgaatag taaaagaaat 840atttccaaca ggaagagtag agcatactga
agaatgcaca tgcggatttg ccagcaataa 900aaccatagaa tgtgcctgta
gagataacag ttacacagca aaaagaccct ttgtcaaatt 960aaatgtggaa
actgatacag cagaaataag attgatgtgc acagagactt atttggacac
1020ccccagacca gatgatggaa gcataacagg gccttgcgaa tctaatgggg
acaaagggag 1080tggaggtatc aagggaggat ttgtccatca aagaatggca
tccaagattg gaagatggta 1140ctctcgaacg atgtctaaaa ctaaaagaat
ggggatggaa ctgtatgtca agtatgatgg 1200agacccatgg actgacagtg
atgcccttgc tcctagtgga gtaatggtct caatagaaga 1260acctggttgg
tattctttcg gcttcgaaat aaaagataag aaatgcgatg tcccctgtat
1320tgggatagag atggtacacg atggtggaaa aacaacttgg cactcagcag
caacagccat 1380ttactgttta atgggctcag gacagttgct atgggacact
atcacaggtg ttgatatggc 1440tctgtaatgg aggaatggtt gaatctgttc
taaacccttt gttcctattt tgtttgaaca 1500attgtcctta ctggacttaa
ttgtttctga aaaatgctct tgtt 1544311885DNAinfluenza B virus
31agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg
60gtagtaacat ccaatgcaga tcgaatctgc actgggataa catcgtcaaa ctcaccccat
120gtggtcaaaa ctgctactca aggggaggtc aatgtgactg gtgtgatacc
actgacaaca 180acacccacca aatctcattt tgcaaatctc aaaggaacaa
aaaccagagg gaaactatgc 240ccaaaatgcc tcaactgcac agatctggac
gtggccttgg gcagaccaaa atgcacgggg 300aacataccct cggcaaaagt
ttcaatactc catgaagtca gacctgttac atctgggtgc 360tttcctataa
tgcacgacag aacaaaaatt agacagctgc ccaatcttct cagaggatac
420gaacatatca ggttatcaac tcataacgtt atcaatgcag aaaaggcacc
aggaggaccc 480tacaaaattg gaacctcagg gtcttgccct aacgttacca
atggaaacgg atttttcgca 540acaatggctt gggccgtccc aaaaaacgac
aacaacaaaa cagcaacaaa ttcattaaca 600atagaagtac catacatttg
tacagaagga gaagaccaaa ttaccgtttg ggggttccac 660tctgataacg
aagcccaaat ggcaaaactc tatggggact caaagcccca gaagttcacc
720tcatctgcca acggagtgac cacacattac gtttcacaga ttggtggctt
cccaaatcaa 780acagaagacg gaggactacc acaaagtggt agaattgttg
ttgattacat ggtgcaaaaa 840tctgggaaaa caggaacaat tacctatcaa
agaggtattt tattgcctca aaaagtgtgg 900tgcgcaagtg gcaggagcaa
ggtaataaaa ggatccttgc ctttaattgg agaagcagat 960tgcctccacg
aaaaatacgg tggattaaac aaaagcaagc cttactacac aggggaacat
1020gcaaaggcca taggaaattg cccaatatgg gtgaaaacac ccttgaagct
ggccaatgga 1080accaaatata gacctcctgc aaaactatta aaggaaagag
gtttcttcgg agctattgct 1140ggtttcttag aaggaggatg ggaaggaatg
attgcaggtt ggcacggata cacatcccat 1200ggggcacatg gagtagcagt
ggcagcagac cttaagagta ctcaagaagc cataaacaag 1260ataacaaaaa
atctcaactc tttgagtgag ctggaagtaa agaatcttca aagactaagc
1320ggtgccatgg atgaactcca caacgaaata ctagaactag acgagaaagt
ggatgatctc 1380agagctgata caataagctc acaaatagaa ctcgcagtct
tgctttccaa tgaaggaata 1440ataaacagtg aagatgagca tctcttggcg
cttgaaagaa agctgaagaa aatgctgggc 1500ccctctgctg tagagatagg
gaatggatgc ttcgaaacca aacacaagtg caaccagacc 1560tgtctcgaca
gaatagctgc tggtaccttt gatgcaggag aattttctct ccccactttt
1620gattcactga atattactgc tgcatcttta aatgacgatg gattggataa
tcatactata 1680ctgctttact actcaactgc tgcctccagt ttggctgtaa
cattgatgat agctatcttt 1740gttgtttata tggtctccag agacaatgtt
tcttgctcca tctgtctata aggaaagtta 1800agccctgtat tttcctttat
tgtagtgctt gtttgcttgt taccattaca aaaaaacgtt 1860attgaaaaat
gctcttgtta ctact 1885321557DNAinfluenza B virus 32agcagaagca
gagcatcttc tcaaaactga ggcaaatagg ccaaaaatga acaatgctac 60cttcaactat
acaaacgtta accctatttc tcacatcagg gggagtatta ttatcactat
120atgtgtcagc ttcattgtca tacttactat attcggatat attgctaaaa
ttctcaccaa 180cagaaataac tgcaccaaca atgccattgg attgtgcaaa
cgcatcaaat gttcaggctg 240tgaaccgttc tgcaacaaaa ggggtgacac
ttcttctccc agaaccagag tggacatacc 300cgcgtttatc ttgcccgggc
tcaacctttc agaaagcact cctaattagc cctcatagat 360tcggagaaac
caaaggaaac tcagctccct tgataataag ggaacctttt attgcttgtg
420gaccaaagga atgcaaacac tttgctctaa cccattatgc agcccaacca
gggggatact 480acaatggaac aagaggagac agaaacaagc tgaggcatct
aatttcagtc aaattgggca 540aaatcccaac agtagaaaac tccattttcc
acatggcagc atggagcggg tccgcatgcc 600atgatggtaa agaatggaca
tatatcggag ttgatggccc tgacaataat gcattgctca 660aaataaaata
tggagaagca tatactgaca cataccattc ctatgcaaac aacatcctaa
720gaacacaaga aagtgcctgc aattgcatcg ggggaaattg ttatcttatg
ataactgatg 780gctcagcttc aggtattagt gaatgcagat ttcttaaaat
tcgagagggc cgaataataa 840aagaaatatt tccaacagga agagtaaaac
atactgaaga atgcacatgc ggatttgcca 900gcaataagac catagaatgt
gcctgtagag ataacagtta cacagcaaaa agaccctttg 960tcaaattaaa
cgtggagact gatacagcag aaataagatt gatgtgcaca gagacttatt
1020tggacacccc cagaccagat gatggaagca taacagggcc ttgtgaatct
aatggggaca 1080aagggagtgg aggcatcaag ggaggatttg ttcatcaaag
aatggcatcc aagattggaa 1140ggtggtactc tcgaacgatg tctaaaacta
aaaggatggg gatgggactg tatgtcaagt 1200atgatggaga cccatgggct
gacagtgatg cccttgctct tagtggagta atggtttcaa 1260tggaagaacc
tggttggtac tcctttggct tcgaaataaa agataagaaa tgtgatgtcc
1320cctgtattgg aatagagatg gtacatgatg gtggaaaaga gacttggcac
tcagcagcaa 1380cagccattta ctgtttaatg ggctcaggac agctgctgtg
ggacactgtc acaggtgttg 1440atatggctct gtaatggagg aatggttgag
tctgttctaa accctttgtt cctattttgt 1500ttgaacaatt gtccttactg
aacttaattg tttctgaaaa atgctcttgt tactact 1557331853DNAinfluenza B
virus 33tctaatatcc acaaaatgaa ggcaataatt gtactactca tggtagtaac
atccaatgca 60gatcgaatct gcactgggat aacatcttca aactcacctc atgtggtcaa
aacagctact 120caaggggagg tcaatgtgac tggtgtaata ccactgacaa
caacaccaac aaaatcttat 180tttgcaaatc tcaaaggaac aaggaccaga
gggaaactat gtccagactg tctcaactgt 240acagatctgg atgtggcctt
gggcagacca atgtgtgtgg ggaccacacc ttcggcaaaa 300gcttcaatac
tccacgaagt cagacctgtt acatccgggt gctttcctat aatgcacgac
360agaacaaaaa tcagacaact acccaatctt ctcagaggat atgaaaatat
cagattatca 420acccaaaacg ttatcgatgc agaaaatgca ccaggaggac
cctacagact tggaacctca 480ggatcttgcc ctaacgctac cagtaaaagc
ggatttttcg caacaatggc ttgggctgtc 540ccaaaggaca acaacaaaaa
tgcaacgaac ccactaacag tagaagtacc atacgtttgt 600acagaagggg
aagaccaaat tactgtttgg gggttccatt cagataacaa aaccccaatg
660aagaacctct atggagactc aaatcctcaa aagttcacct catctgctaa
tggagtaacc 720acacattatg tttctcagat tggcggcttc ccagctcaaa
cagaagacga aggactacca 780caaagcggca gaattgttgt tgattacatg
gtgcaaaaac ctaggaaaac aggaacaatt 840gtctatcaaa gaggtgtttt
gttgcctcaa aaggtgtggt gcgcgagtgg caggagcaaa 900gtaataaaag
ggtccttgcc tttaattggt gaagcagatt gccttcatga aaaatacggt
960ggattaaaca aaagcaagcc ttactacaca ggagaacatg caaaagccat
aggaaattgc 1020ccaatatggg tgaaaacacc tttgaagctt gccaatggaa
ccaaatatag acctcctgca 1080aaactattaa aggaaagggg tttcttcgga
gctattgctg gtttcctaga aggaggatgg 1140gaaggaatga ttgcaggttg
gcacggatac acatctcacg gagcacatgg agtggcagtg 1200gcggcagacc
ttaagagtac gcaagaagct ataaacaaga taacaaaaaa tctcaattct
1260ttgagtgagc tagaagtaaa gaatcttcaa agactaagtg gtgccatgga
tgaactccac 1320aacgaaatac tcgagctgga tgagaaagtg gatgatctca
gagctgacac tataagctcg 1380caaatagaac ttgcagtctt gctttccaat
gaaggaataa taaacagtga agatgagcat 1440ctattggcac ttgagagaaa
actaaagaaa atgctgggtc cctctgctgt agacatagga 1500aatggatgct
tcgaaaccaa acacaagtgc aaccagacct gcttagacag gatagctgct
1560ggcaccttta atgcaggaga attttctctc cccacttttg attcactgaa
cattactgct 1620gcatctttaa atgatgatgg attggataac catactatac
tgctctatta ctcaactgct 1680gcttctagtt tggctgtaac attgatgcta
gctattttta ttgtttatat ggtctccaga 1740gacaacgttt catgctccat
ctgtctataa ggaagattaa gccttgtatt ttcctttatt 1800gtagtgcttg
tttgcttgtc atcattacaa agaaacgtta ttgaaaaatg ctc
1853341529DNAinfluenza B virus 34tctcaaaact gaggcaaata ggccaaaaat
gaacaatgct accctcaact atacaaacgt 60taaccctatt cctcacatca gggggagtgt
tattatcact atatgtgtca gcttcactgt 120catacttact atattcggat
atattgctaa aattttcaac aacagaaata actgcaccaa 180caatgccatt
ggattgtgca aacgcatcaa atgttcaggc tgtgaaccgt tctgcaacaa
240aaggggtgac acttcttctc ccagaaccgg agtggacata cccgcgttta
tcttgcccgg 300gctcaacctt tcagaaagca ctcctaatta gccctcatag
attcggagaa accaaaggaa 360actcagctcc cttgataata agggaacctt
ttattgcttg tggaccaaag gaatgcaaac 420actttgctct aacccattat
gcagcccaac cagggggata ctacaatgga acaaaagaag 480acagaaacaa
gctgaggcat ctaatttcag tcaaattggg caaaatccca acagtagaaa
540actccatttt ccacatggca gcatggagcg ggtccgcatg ccatgatggt
aaagaatgga 600catatatcgg agttgatggc cctgacagta atgcattgct
caaaataaaa tatggagaag 660catatactga cacataccat tcctatgcaa
acaacatcct aagaacacaa gaaagtgcct 720gcaattgcat cgggggaaat
tgttatctta tgataactga tggctcagct tcaggtatta 780gtgagtgcag
atttcttaag attcgagagg gccgaataat aaaagaaata tttccaacag
840gaagagtaaa acatactgaa gaatgcacat gcggatttgc cagcaataaa
accatagaat 900gtgcctgtag agataacagt tacacagcaa aaagaccctt
tgtcaaatta aatgtggaga 960ctgatacagc agaaataaga ttgatgtgca
cagagactta tttggacacc cccagaccag 1020atgatggaag cataacaggg
ccttgtgaat ctaatgggaa taaagggagt ggaggcatca 1080agggaggatt
tgttcatcaa agaatggcat ccaaaattgg aaggtggtac tctcgaacaa
1140tgtctaaaac caaaaggatg ggaatgggac tgtatgtcaa gtatgatgga
gacccatgga 1200ctgacagtga tgcccttgct cttagtggag taatggtttc
aatggaagaa cctggttggt 1260actcatttgg cttcgaaata aaagataaga
aatgtgatgt cccctgtatt gggatagaga 1320tggtacatga tggtggaaag
gagacttggc actcagcagc aacagccatt tactgtttaa 1380tgggctcagg
acaactgttg tgggacactg tcacaggtgt tgatatggct ctgtaatggg
1440ggaatggttg agtctgttct aaaccctttg ttcctatttt gtttgaacaa
ttgtccttgc 1500tgaacttaat tgtttctgaa aaatgctct
1529351721DNAinfluenza A virus 35ctattaacca tgaagactat cattgctttg
agctacattc tatgtctggt tttcgctcaa 60aaacttcccg gaaatgacaa cagcacggca
acgctgtgcc ttgggcacca tgcagtacca 120aacggaacga tagtgaaaac
aatcacgaat gaccaaattg aagttactaa tgctactgag 180ctggttcaga
gttcctcaac aggtggaata tgcgacagtc ctcatcagat ccttgatgga
240gaaaactgca cactaataga tgctctattg ggagaccctc agtgtgatgg
cttccaaaat 300aagaaatggg acctttttgt tgaacgcagc aaagcctaca
gcaactgtta cccttatgat 360gtgccggatt atgcctccct taggtcacta
gttgcctcat ccggcacact ggagtttaac 420aatgaaagct tcaattggac
tggagtcact caaaatggaa caagctcttc ttgcaaaagg 480agatctaata
acagtttctt tagtagattg aattggttga cccatttaaa attcaaatac
540ccagcattga acgtgactat gccaaacaat gaaaaatttg acaaattgta
catttggggg 600gttcaccacc cgggtacgaa caatgaccaa atcagcctat
atactcaagc atcaggaaga 660atcacagtct ctaccaaaag aagccaacaa
actgtaatcc cgaatatcgg atctagaccc 720agggtaaggg atatccccag
cagaataagc atctattgga caatagtaaa accgggagac 780atacttttga
ttaacagcac agggaatcta attgctcctc ggggttactt caaaatacga
840agtgggaaaa gctcaataat gagatcagat gcacccattg gcaaatgcaa
ttctgaatgc 900atcactccaa atggaagcat tcccaatgac aaaccatttc
aaaatgtaaa caggatcaca 960tatggggcct gtcccagata tgttaagcaa
aacactctga aattggcaac agggatgcga 1020aatgtaccag agaaacaaac
tagaggcata tttggcgcaa tcgcgggttt catagaaaat 1080ggttgggagg
gaatggtgga tggttggtac ggtttcaggc atcaaaattc tgagggaata
1140ggacaagcag cagatctcaa aagcactcaa gcagcaatca accaaatcaa
tgggaagctg 1200aataggttga tcgggaaaac caacgagaaa ttccatcaga
ttgaaaaaga attctcagaa 1260gtagaaggga gaattcagga cctcgagaaa
tatgttgagg acactaaaat agatctctgg 1320tcatacaacg cggagcttct
tgttgccctg gagaaccaac atacaattga tctaactgac 1380tcagaaatga
acaaactgtt tgaaagaaca aagaagcaac tgagggaaaa tgctgaggat
1440atgggcaatg gttgtttcaa aatataccac aaatgtgaca atgcctgcat
agggtcaatc 1500agaaatggaa cttatgacca tgatgtatac agagatgaag
cattaaacaa ccggttccag 1560atcaaaggtg ttgagctgaa gtcaggatac
aaagattgga tcctatggat ttcctttgcc 1620atatcatgtt ttttgctttg
tgttgctttg ttggggttca tcatgtgggc ctgccaaaaa 1680ggcaacatta
ggtgcaacat ttgcatttga gtgcattaat t 1721361426DNAinfluenza A virus
36atgaatccaa atcaaaagat aataacgatt ggctctgttt ctctcaccat ttccacaata
60tgcttcttta tgcaaattgc catcttgata actactgtaa cattgcattt caagcaatat
120gaattcaact cccccccaaa caaccaagtg atgctgtgtg aaccaacaat
aatagaaaga 180aacataacag agatagtgta tctgaccaac accaccatag
agaaggaaat atgccccaaa 240ctagcagaat acagaaattg gtcaaagccg
caatgtgaca ttacaggatt tgcacctttt 300tctaaggaca attcgattag
gctttccgct ggtggggaca tctgggtgac aagagaacct
360tatgtgtcat gcgatcctga caaatgttat caatttgccc ttggacaggg
aacaacacta 420aacaacgtgc attcaaatga cacagtacat gataggaccc
cttatcggac cctattgatg 480aatgagttag gtgttccatt tcatctgggg
actaagcaag tgtgcatagc atggtccagc 540tcaagttgtc acgatggaaa
agcatggctg catgtttgtg taacggggga tgataaaaat 600gcaactgcta
gcttcattta caatgggagg cttgtagata gtattgtttc atggtccaaa
660gaaatcctca gaacccagga gtcagaatgc gtttgtatca atggaacttg
tacagtagta 720atgactgatg ggagtgcttc aggaaaagct gatactaaaa
tactattcat tgaggagggg 780aaaatcgttc atactagcac attgtcagga
agtgcccagc atgtcgagga gtgctcctgc 840tatcctcgat atcctggtgt
cagatgtgtc tgcagagaca actggaaagg ctccaatagg 900cccatcgtag
atataaacat aaaggattat agcattgttt ccagttatgt gtgctcagga
960cttgttggag acacacccag aaaaaacgac agctccagca gtagccattg
cttggatcct 1020aacaatgaag aaggtggtca tggagtgaaa ggctgggcct
ttgatgatgg aaatgacgtg 1080tggatgggaa gaacgatcag cgagaagtta
cgctcaggat atgaaacctt caaagtcatt 1140gaaggctggt ccaaccctaa
ttccaaattg cagataaata ggcaagtcat agttgacaga 1200ggtaataggt
ccggttattc tggtattttc tctgttgaag gcaaaagctg catcaatcgg
1260tgcttttatg tggagttgat aaggggaaga aaagaggaaa ctgaagtctt
gtggacctca 1320aacagtattg ttgtgttttg tggcacctca ggtacatatg
gaacaggctc atggcctgat 1380ggggcggaca tcaatctcat gcctatataa
gctttcgcaa ttttag 1426371736DNAinfluenza A virus 37gataattcta
ttaaccatga agactatcat tgctttgagc tacattctat gtctggtttt 60cgctcaaaag
cttcccggaa atgacaacag cacggcaacg ctgtgccttg ggcaccatgc
120agtaccaaac ggaacgatag tgaaaacaat cacgaatgac caaattgaag
ttactaatgc 180tactgagctg gttcagagtt cctcaacagg tggaatatgc
gacagccctc atcagatcct 240tgatggagaa aactgcacac taatagatgc
tctattggga gaccctcagt gtgatggctt 300ccaaaataag aaatgggacc
tttttgttga acgcagcaaa gcctacagca actgttaccc 360ttatgatgtg
ccggattatg cctcccttag gtcactagtt gcctcatccg gcacactgga
420gtttaacaat gaaagcttca attggactgg agtcactcag aatggaacaa
gctctgcttg 480caaaaggaga tctaataaaa gtttctttag tagattgaat
tggttgaccc acttaaaata 540caaataccca gcattgaacg tgactatgcc
aaacaatgaa aaatttgaca aattgtacat 600ttggggggtt caccacccgg
gtacggacag tgaccaaatc agcctatatg ctcaagcatc 660aggaagaatc
acagtctcta ccaaaagaag ccaacaaact gtaatcccga atatcggatc
720tagacccagg gtaagggatg tctccagcag aataagcatc tattggacaa
tagtaaaacc 780gggagacata cttttgatta acagcacagg gaatctaatt
gctcctcggg gttacttcaa 840aatacgaagt gggaaaagct caataatgag
atcagatgca cccattggca aatgcaattc 900tgaatgcatc actccaaatg
gaagcattcc caatgacaaa ccatttcaaa atgtaaacag 960gatcacatat
ggggcctgtc ccagatatgt taagcaaaac actctgaaat tggcaacagg
1020gatgcgaaat gtaccagaga aacaaactag aggcatattt ggcgcaatcg
cgggtttcat 1080agaaaatggt tgggagggaa tggtggacgg ttggtacggt
ttcaggcatc aaaattctga 1140gggcacagga caagcagcag atctcaaaag
cactcaagca gcaatcaacc aaatcaatgg 1200gaaactgaat aggttaatcg
ggaaaacaaa cgagaaattc catcagattg aaaaagaatt 1260ctcagaagta
gaagggagaa ttcaggacct cgagaaatat gttgaggaca ctaaaataga
1320tctctggtca tacaacgcgg agcttcttgt tgccctggag aaccaacata
caattgatct 1380aactgactca gaaatgaaca aactgtttga aagaacaaag
aagcaactga gggaaaatgc 1440tgaggatatg ggcaatggtt gtttcaaaat
ataccacaaa tgtgacaatg cctgcataga 1500gtcaatcaga aatggaactt
atgaccatga tgtatacaga gatgaagcat taaacaaccg 1560gttccagatc
aaaggtgttg agctgaagtc aggatacaaa gattggatcc tatggatttc
1620ctttgccata tcatgttttt tgctttgtgt tgctttgttg gggttcatca
tgtgggcctg 1680ccaaaaaggc aacattaggt gcaacatttg catttgagtg
cattaattaa aaacac 1736381438DNAinfluenza A virus 38atgaatccaa
atcaaaagat aataacgatt ggctctgttt ccctcaccat ttccacaata 60tgcttcttca
tgcaaattgc catcctgata actactgtaa cattgcattt caagcaatat
120gaattcaact cccccccaaa caaccaagtg atgctgtgtg aaccaacaat
aatagaaaga 180aacataacag agatagtgta tctgaccaac accaccatag
agaaggaaat atgccccaaa 240ctagcagaat acagaaattg gtcaaagccg
caatgtaaca ttacaggatt tgcacctttt 300tctaaggaca attcgattcg
gctttccgct ggtggggaca tctgggtgac aagacaacct 360tatgtgtcat
gcgatcctga caagtgttat caatttgccc ttggaaaggg aacaacacta
420aacaacgtgc attcaaatga cacagtacat gataggaccc cttatcggac
cctattgatg 480aatgagttgg gtgttccatt tcatctgggg accaagcaag
tgtgcatagc atggtccagc 540tcaagttgtc acgatggaaa agcatggctg
catgtttgtg taacggggga tgatgaaaat 600gcaactgcta gcttcattta
caatgggagg cttgtagata gtattgtttc atggtccaaa 660aaaatcctca
ggacccagga gtcagaatgc gtttgtatca atggaacttg tacagtagta
720atgactgatg ggagtgcttc aggaaaagct gatactaaaa tactattcat
tgaggagggg 780aaaattgttc atactagcac attatcagga agtgctcagc
atgtcgagga gtgctcctgt 840tatcctcgat atcctggtgt cagatgtgtc
tgcagagaca actggaaagg ctccaatagg 900cccatcgtag atataaacat
aaaggattat agcattgttt ccagttatgt gtgctcagga 960cttgttggag
acacacccag aaaaaacgac agctccagca gtagccattg cttggatcca
1020aacaatgagg aaggtggtta tggagtgaaa ggctgggctt ttgatgatgg
aaatgacgtg 1080tggatgggaa gaacgatcag cgagaagtta cgctcaggat
atgaaacctt caaagtcatt 1140gaaggctggt ccaaccctaa ctccaaattg
cagataaata ggcaagtcat agttgacaga 1200ggtaacaggt ccggttattc
tggtattttc tctgttgaag gcaaaagctg catcaatcgg 1260tgcttttatg
tggagttgat aaggggaaga aaacaggaaa ctgaagtctt gtggacctca
1320aacagtattg ttgtgttttg tggcacctca ggtacatatg gaacaggctc
atggcctgat 1380ggggcggaca tcaatctcat gcctatataa gctttcgcaa
ttttagaaaa aaactcct 1438391723DNAinfluenza A virus 39ttctattaac
catgaagact atcattgctt tgagctacat tctatgtctg gttttcgctc 60aaaaacttcc
cggaaatgac aacagcacgg caacgctgtg ccttgggcac catgcagtac
120caaacggaac gatagtgaaa acaatcacga atgaccaaat tgaagttact
aatgctactg 180agctggttca gagttcctca acaggtggaa tatgcgacag
tcctcatcag atccttgatg 240gagaaaactg cacactaata gatgctctat
tgggagaccc tcagtgtgat ggcttccaaa 300ataagaaatg ggaccttttt
gttgaacgca gcaaagccta cagcaactgt tacccttatg 360atgtgccgga
ttatgcctcc cttaggtcac tagttgcctc atccggcaca ctggagttta
420acaatgaaag cttcaattgg actggagtca ctcaaaatgg aacaagctct
gcttgcaaaa 480ggagatctaa taaaagtttc tttagtagat tgaattggtt
gacccactta aaattcaaat 540acccagcatt gaacgtgact atgccaaaca
atgaaaaatt tgacaaattg tacatttggg 600gggttcacca cccgggtacg
gacaatgacc aaatcaacct atatgttcaa gcatcaggaa 660gaatcacagt
ctctaccaaa agaagccaac aaactgtaat cccgaatatc ggatctagac
720ccagagtaag ggatgtcccc agcagaataa gcatctattg gacaatagta
aaaccgggag 780acatactttt gattagcagc acagggaatc taattgctcc
tcggggttac ttcaaaatac 840gaagtgggaa aagctcaata atgagatcag
atgcacccat tggcaaatgc aattctgaat 900gcatcactcc aaatggaagc
attcccaatg acaaaccatt tcaaaatgta aacaggatca 960catatggggc
ctgtcccaga tatgttaagc aaaacactct gaaattggca acagggatgc
1020gaaatgtacc agagaaacaa actagaggca tatttggcgc aatcgcgggt
ttcatagaaa 1080atggttggga gggaatggtg gacggttggt acggtttcag
gcatcaaaat tctgagggaa 1140caggacaagc agcagatctc aaaagcactc
aagcagcaat caaccaaatc aatgggaagc 1200tgaataggtt gatcgggaaa
acaaacgaga aattccatca gattgaaaaa gaattctcag 1260aagtagaagg
gagaattcag gacctcgaga aatatgttga ggacactaaa atagatctct
1320ggtcatacaa cgcggagctt cttgttgccc tggagaacca acatacaatt
gatctaactg 1380actcagaaat gaacaaactg tttgaaagaa caaagaagca
actgagggaa aatgctgagg 1440atatgggcaa tggttgtttc aaaatatacc
acaaatgtga caatgcctgc atagggtcaa 1500tcagaaatgg aacttatgac
catgatgtat acagagatga agcattaaac aaccggttcc 1560agatcaaagg
tgttgagctg aagtcaggat acaaagattg gatcctatgg atttcctttg
1620ccatatcatg ttttttgctt tgtgttgctt tgttggggtt catcatgtgg
gcctgccaaa 1680aaggcaacat taggtgcaac atttgcattt gagtgcatta att
1723401428DNAinfluenza A virus 40aaatgaatcc aaatcaaaag ataataacga
ttggctctgt ttctctcacc atttccacaa 60tatgcttctt catgcaaatt gccatcttga
taactactgt aacattgcat ttcaagcaat 120atgaattcaa ctccccccca
aacaaccaag tgatgctgtg tgaaccaaca ataatagaaa 180gaaacataac
agagatagtg tatctgacca acaccaccat agagaaggaa atatgcccca
240aactagcaga atacagaaat tggtcaaagc cgcaatgtga cattacagga
tttgcacctt 300tttctaagga caattcgatt aggctttccg ctggtgggga
catctgggtg acaagagaac 360cttatgtgtc atgcgatcct gacaagtgtt
atcaatttgc ccttggacag ggaacaacac 420taaacaacgt gcattcaaat
gacacagtac atgataggac cccttatcgg accctattga 480tgaatgagtt
aggtgttcca tttcatctgg ggaccaagca agtgtgcata gcatggtcca
540gctcaagttg tcacgatgga aaagcatggc tgcatgtttg tgtaacgggg
gatgataaaa 600atgcaactgc tagcttcatt tacaatggga ggcttgtaga
tagtattgtt tcatggtcca 660aaaaaatcct caggacccag gagtcagaat
gcgtttgtat caatggaact tgtacagtag 720taatgactga tgggagtgct
tcaggaaaag ctgatactaa aatactattc attgaggagg 780ggaaaatcgt
tcatactagc acattgtcag gaagtgctca gcatgtcgag gagtgctcct
840gctatcctcg atatcctggt gtcagatgtg tctgcagaga caactggaaa
ggctccaata 900ggcccatcgt agatataaac ataaaggatt atagcattgt
ttccagttat gtgtgctcag 960gacttgttgg agacacaccc agaaaaaacg
acagctccag cagtagccat tgcttggatc 1020ctaacaatga agaaggtggt
catggagtga aaggctgggc ctttgatgat ggaaatgacg 1080tgtggatggg
aagaacgatc agcgagaagt tacgctcagg atatgaaacc ttcaaagtca
1140ttgaaggctg gtccaaccct aattccaaat tgcagataaa taggcaagtc
atagttgaca 1200gaggtaatag gtccggttat tctggtattt tctctgttga
aggcaaaagc tgcatcaatc 1260ggtgctttta tgtggagttg ataaggggaa
gaaaagagga aactaaagtc ttgtggacct 1320caaacagtat tgttgtgttt
tgtggcacct caggtacata tggaacaggc tcatggcctg 1380atggggcgga
catcaatctc atgcctatat aagctttcgc aattttag 1428411724DNAinfluenza A
virus 41attctattaa ccatgaagac tatcattgct ttgagctaca ttctatgtct
ggttttcgct 60caaaaacttc ccggaaatga caacagcacg gcaacgctgt gccttgggca
ccatgcagta 120ccaaacggaa caatagtgaa aacaatcacg aatgaccaaa
ttgaagttac taatgctact 180gagctggttc agaattcctc aacaggtgga
atatgcgaca gtcctcatca gatccttgat 240ggagaaaact gcacactaat
agatgctcta ttgggagacc ctcagtgtga tggcttccaa 300aataagaaat
gggacctttt tgttgaacgc agcaaggcct acagcaactg ttacccttat
360gatgtgccgg attatgcctc ccttaggtca ctagttgcct catccggcac
actggagttt 420aacaatgaaa gcttcaattg gactggagtc actcaaaatg
gaacaagctc tgcttgcaaa 480aggagatcta ataaaagttt ctttagtaga
ttgaattggt tgacccactt aaaattcaaa 540tacccagcat tgaacgtgac
tatgccaaac aatgaaaaat ttgacaaatt gtacatttgg 600ggggttcacc
acccgggtac ggactatgac caaatccgcc tatatgctca agcatcagga
660agaatcacag tctctaccaa aagaagccaa caaactgtaa tcccgaatat
cggatctaga 720cccagggtaa gggatatccc cagcagaata agcatctatt
ggacaatagt aaaaccggga 780gacatacttt tgattaacag cacagggaat
ctaattgctc ctcggggtta cttcaaaata 840cgaagtggga aaagctcaat
aatgagatca gatgcaccca ttggcaaatg caattctgaa 900tgcatcactc
caaatggaag cattcccaat gacaaaccat ttcaaaatgt aaacaggatc
960acatatgggg cctgtcccag atatgttaag caaaacactc tgaaattggc
aacagggatg 1020cgaaacgtac cagagaaaca aactagaggc atatttggcg
caatcgcggg tttcatagaa 1080aatggttggg agggaatggt ggacggttgg
tacggtttca ggcatcaaaa ttctgaggga 1140acaggacaag cagcagatct
caaaagcact caagcagcaa tcaaccaaat caatgggaag 1200ctgaataggt
tgatcgggaa aacaaacgag aaattccatc agattgaaaa agaattctca
1260gaagtagaag ggagaattca ggacctcgag aaatatgttg aggacactaa
aatagatctc 1320tggtcataca acgcggagct tcttgttgcc ctggagaacc
aacatacaat tgatctaact 1380gactcagaaa tgaacaaact gtttgaaaga
acaaagaagc aactgaggga aaatgctgag 1440gatatgggca atggttgttt
caaaatatac cacaaatgtg acaatgcctg catagggtca 1500atcagaaatg
gaacttatga ccatgatgta tacagagatg aagcattaaa caaccggttc
1560cagatcaaag gtgttgagct gaagtcagga tacaaagatt ggatcctatg
gatttccttt 1620gccatatcat gttttttgct ttgtgttgct ttgtcggggt
tcatcatgtg ggcctgccaa 1680aaaggcaaca ttaggtgcaa catttgcatt
tgagtgcatt aatt 1724421426DNAinfluenza A virus 42atgaatccaa
atcaaaagat aataacgatt ggctctgttt ctctcaccat ttccacaata 60tgcttcttca
tgcaaattgc catcttgata actactgtaa cattgcattt caagcaatat
120gaattcaact cccccccaaa caaccaagtg atgctgtgtg aaccaacaat
aatagaaaga 180aacataacag agatagtgta tctgaccaac accaccatag
agaaggaaat atgccccaaa 240ctagcagaat acagaaattg gtcaaagccg
caatgtgaca ttacaggatt tgcacctttt 300tctaaggaca attcgattag
gctttccgct ggtggggaca tctgggtgac aagagaacct 360tatgtgtcat
gcgatcctga caagtgttat caatttgccc ttggacaggg aacaacacta
420aacaacgtgc attcaaatga cacagtacat gataggaccc cttatcggac
cctattgatg 480aatgagttag gtgttccatt tcatctgggg accaagcaag
tgtgcatagc atggtccagc 540tcaagttgtc acgatggaaa agcatggctg
catgtttgtg taacggggga tgataaaaat 600gcaactgcta gcttcattta
caatgggagg cttgtagata gtattgtttc atggtccaaa 660aaaatcctca
ggacccagga gtcagaatgc gtttgtatca atggaacttg tacagtagta
720atgactgatg ggagtgcttc aggaaaagct gatactaaaa tactattcat
tgaggagggg 780aaaatcgttc atactagcac attgtcagga agtgctcagc
atgtcgagga gtgctcctgc 840tatcctcgat atcctggtgt cagatgtgtc
tgcagagaca actggaaagg ctccaatagg 900cccatcgtag atataaacat
aaaggattat agcattgttt ccagttatgt gtgctcagga 960cttgttggag
acacacccag aaaaaacgac agctccagca gtagccattg cttggatcct
1020aacaatgaag aaggtggtca tggagtgaaa ggctgggcct ttgatgatgg
aaatgacgtg 1080tggatgggaa gaacgatcag cgagaagtta cgctcaggat
atgaaacctt caaagtcatt 1140gaaggctggt ccaaccctaa ttccaaattg
cagataaata ggcaagtcat agttgacaga 1200ggtaataggt ccggttactc
tggtattttc tctgttgaag gcaaaagctg catcaatcgg 1260tgcttttatg
tggagttgat aaggggaaga aaagagaaaa ctgaagtctt gtggacctca
1320aacagtattg ttgtgttttg tggcacctca ggtacatatg gaacaggctc
atggcctgat 1380ggggcggaca tcaatctcat gcctatataa gctttcgcaa ttttag
1426431724DNAinfluenza A virus 43attctattaa ccatgaagac tatcattgct
ttgagctaca ttctatgtct ggttttcgct 60caaaaacttc ccggaaatga caacagcacg
gcaacgctgt gccttgggca ccatgcagta 120ccaaacggaa caatagtgaa
aacaatcacg aatgaccaaa ttgaagttac taatgctact 180gagctggttc
agaattcctc aacaggtgga atatgcgaca gtcctcatca gatccttgat
240ggagaaaact gcacactaat agatgctcta ttgggagacc ctcagtgtga
tggcttccaa 300aataagaaat gggacctttt tgttgaacgc agcaaggcct
acagcaactg ttacccttat 360gatgtgccgg attatgcctc ccttaggtca
ctagttgcct catccggcac actggagttt 420aacaatgaaa gcttcaattg
gactggagtc actcaaaatg gaacaagctc tgcttgcaaa 480aggagatcta
ataaaagttt ctttagtaga ttgaattggt tgacccactt aaaattcaaa
540tacccagcat tgaacgtgac tatgccaaac aatgaaaaat ttgacaaatt
gtacatttgg 600ggggttcacc acccggttac ggactatgac caaatcagcc
tatatgctca agcatcagga 660agaatcacag tctctaccaa aagaagccaa
caaactgtaa tcccgaatat cggatctaga 720cccagggtaa gggatatccc
cagcagaata agcatctatt ggacaatagt aaaaccggga 780gacatacttt
tgattaacag cacagggaat ctaattgctc ctcggggtta cttcaaaata
840cgaagtggga aaagctcaat aatgagatca gatgcaccca ttggcaaatg
caattctgaa 900tgcatcactc caaatggaag cattcccaat gacaaaccat
ttcaaaatgt aaacaggatc 960acatatgggg cctgtcccag atatgttaag
caaaacactc tgaaattggc aacagggatg 1020cgaaacgtac cagagaaaca
aactagaggc atatttggcg caatcgcggg tttcatagaa 1080aatggttggg
agggaatggt ggacggttgg tacggtttca ggcatcaaaa ttctgaggga
1140acaggacaag cagcagatct caaaagcact caagcagcaa tcaaccaaat
caatgggaag 1200ctgaataggt tgatcgggaa aacaaacgag aaattccatc
agattgaaaa agaattctca 1260gaagtagaag ggagaattca ggacctcgag
aaatatgttg aggacactaa aatagatctc 1320tggtcataca acgcggagct
tcttgttgcc ctggagaacc aacatacaat tgatctaact 1380gactcagaaa
tgaacaaact gtttgaaaga acaaagaagc aactgaggga aaatgctgag
1440gatatgggca atggttgttt caaaatatac cacaaatgtg acaatgcctg
catagggtca 1500atcagaaatg gaacttatga ccatgatgta tacagagatg
aagcattaaa caaccggttc 1560cagatcaaag gtgttgagct gaagtcagga
tacaaagatt ggatcctatg gatttccttt 1620gccatatcat gttttttgct
ttgtgttgct ttgtcggggt tcatcatgtg ggcctgccaa 1680aaaggcaaca
ttaggtgcaa catttgcatt tgagtgcatt aatt 1724441427DNAinfluenza A
virus 44aatgaatcca aatcaaaaga taataacgat tggctctgtt tctctcacca
tttccacaat 60atgcttcttc atgcaaattg ccatcttgat aactactgta acattgcatt
tcaagcaata 120tgaattcaac tcccccccaa acaaccaagt gatgctgtgt
gaaccaacaa taatagaaag 180aaacataaca gagatagtgt atctgaccaa
caccaccata gagaaggaaa tatgccccaa 240actagcagaa tacagaaatt
ggtcaaagcc gcaatgtgac attacaggat ttgcaccttt 300ttctaaggac
aattcgatta ggctttccgc tggtggggac atctgggtga caagagaacc
360ttatgtgtca tgcgatcctg acaagtgtta tcaatttgcc cttggacagg
gaacaacact 420aaacaacgtg cattcaaatg acacagtaca tgataggacc
ccttatcgga ccctattgat 480gaatgagtta ggtgttccat ttcatctggg
gaccaagcaa gtgtgcatag catggtccag 540ctcaagttgt cacgatggaa
aagcatggct gcatgtttgt gtaacggggg atgataaaaa 600tgcaactgct
agcttcattt acaatgggag gcttgtagat agtattgttt catggtccaa
660aaaaatcctc aggacccagg agtcagaatg cgtttgtatc aatggaactt
gtacagtagt 720aatgactgat gggagtgctt caggaaaagc tgatactaaa
atactattca ttgaggaggg 780gaaaatcgtt catactagca cattgtcagg
aagtgctcag catgtcgagg agtgctcctg 840ctatcctcga tatcctggtg
tcagatgtgt ctgcagagac aactggaaag gctccaatag 900gcccatcgta
gatataaaca taaaggatta tagcattgtt tccagttatg tgtgctcagg
960acttgttgga gacacaccca gaaaaaacga cagctccagc agtagccatt
gcttggatcc 1020taacaatgaa gaaggtggtc atggagtgaa aggctgggcc
tttgatgatg gaaatgacgt 1080gtggatggga agaacgatca gcgagaagtt
acgctcagga tatgaaacct tcaaagtcat 1140tgaaggctgg tccaacccta
attccaaatt gcagataaat aggcaagtca tagttgacag 1200aggtaatagg
tccggttact ctggtatttt ctctgttgaa ggcaaaagct gcatcaatcg
1260gtgcttttat gtggagttga taaggggaag aaaagagaaa actgaagtct
tgtggacctc 1320aaacagtatt gttgtgtttt gtggcacctc aggtacatat
ggaacaggct catggcctga 1380tggggcggac atcaatctca tgcctatata
agctttcgca attttag 1427451870DNAinfluenza B virus 45gcagaagcag
agcattttct aatatccaca aaatgaaggc aataattgta ctactcatgg 60tagtaacatc
caatgcagat cgaatctgca ctgggataac atcttcaaac tcacctcatg
120tggtcaaaac agctactcaa ggggaggtca atgtgactgg tgtaatacca
ctgacaacaa 180caccaacaaa atcttatttt gcaaatctca aaggaacaag
gaccagaggg aaactatgtc 240cagactgtct caactgtaca gatctggatg
tggccttggg cagaccaatg tgtgtgggga 300ccacaccttc ggcaaaagct
tcaatactcc acgaagtcag acctgttaca tccgggtgct 360ttcctataat
gcacgacaga acaaaaatca gacaactacc caatcttctc agaggatatg
420aaaatatcag attatcaacc caaaacgtta tcgatgcaga aaatgcacca
ggaggaccct 480acagacttgg aacctcaaga tcttgcccta acgctaccag
taaaagcgga tttttcgcaa 540caatggcttg ggctgtccca aaggacaaca
acaaaaatgc aacgaaccca ctaacagtag 600aagtaccata cgtttgtaca
gaaggggaag accaaattac tgtttggggg ttccattcag 660ataacaaaac
ccaaatgaag aacctctatg gagactcaaa tcctcaaaag ttcacctcat
720ctgctaatgg agtaaccaca cattatgttt ctcagattgg cggcttccca
gctcaaacag 780aagacgaagg actaccacaa agcggcagaa ttgttgttga
ttacatggtg caaaaaccta 840gaaaaacagg aacaattgtc tatcaaagag
gtgttttgtt gcctcaaaag gtgtggtgcg 900cgagtggcag gagcaaagta
ataaaagggt ccttgccttt aattggtgaa gcagattgcc 960ttcatgaaaa
atacggtgga ttaaacaaaa
gcaagcctta ctacacagga gaacatgcaa 1020aagccatagg aaattgccca
atatgggtga aaacaccttt gaagcttgcc aatggaacca 1080aatatagacc
tcctgcaaaa ctattaaagg aaaggggttt cttcggagct attgctggtt
1140tcctagaagg aggatgggaa ggaatgattg caggttggca cggatacaca
tctcacggag 1200cacatggagt ggcagtggcg gcagacctta agagtacgca
agaagctata aacaagataa 1260caaaaaatct caattctttg agtgagctag
aagtaaagaa tcttcaaaga ctaagtggtg 1320ccatggatga actccacaac
gaaatactcg agctggatga gaaagtggat gatctcagag 1380ctgacactat
aagctcgcaa atagaacttg cagtcttgct ttccaatgaa ggaataataa
1440acagtgaaga tgagcatcta ttggcacttg agagaaaact aaagaaaatg
ctgggtccct 1500ctgctgtaga cataggaaat ggatgcttcg aaaccaaaca
caagtgcaac cagacctgct 1560tagacaggat agctgctggc acctttaatg
caggagaatt ttctctcccc acttttgatt 1620cactgaacat tactgctgca
tctttaaatg atgatggatt ggataaccat actatactgc 1680tctattactc
aactgctgct tctagtttgg ctgtaacatt gatgctagct atttttattg
1740tttatatggt ctccagagac aacgtttcat gctccatctg tctataagga
agattaagcc 1800ttgtattttc ctttattgta gtgcttgttt gcttgtcatc
attacaaaga aacgttattg 1860aaaaatgctc 1870461536DNAinfluenza B virus
46aagcagagca tcttctcaaa actgaggcaa ataggccaaa aatgaacaat gctaccctca
60actatacaaa cgttaaccct attcctcaca tcagggggag tgttattatc actatatgtg
120tcagcttcac tgtcatactt actatattcg gatatattgc taaaattttc
aacaacagaa 180acaactgcac caacaatgcc attggattgt gcaaacgcat
caaatgttca ggctgtgaac 240cgttctgcaa caaaaggggt gacacttctt
ctcccagaac cggagtggac atacccgcgt 300ttatcttgcc cgggctcaac
ctttcagaaa gcactcctaa ttagccctca tagattcgga 360gaaaccaaag
gaaactcagc tcccttgata ataagggaac cttttattgc ttgtggacca
420aaggaatgca aacactttgc tctaacccat tatgcagccc aaccaggggg
atactacaat 480ggaacaagag aagacagaaa caagctgagg catctaattt
cagtcaaatt gggcaaaatc 540ccaacagtag aaaactccat tttccacatg
gcagcatgga gcgggtccgc atgccatgat 600ggtaaagaat ggacatatat
cggagttgat ggccctgaca gtaatgcatt gctcaaaata 660aaatatggag
aagcatatac tgacacatac cattcctatg caaacaacat cctaagaaca
720caagaaagtg cctgcaattg catcggggga aattgttatc ttatgataac
tgatggctca 780gcttcaggta ttagtgagtg cagatttctt aagattcgag
agggccgaat aataaaagaa 840atatttccaa caggaagagt aaaacatact
gaagaatgca catgcggatt tgccagcaat 900aaaaccatag aatgtgcctg
tagagataac agttacacag caaaaagacc ctttgtcaaa 960ttaaatgtgg
agactgatac agcagaaata agattgatgt gcacagagac ttatttggac
1020acccccagac cagatgatgg aagtataaca gggccttgtg aatctaatgg
gaataaaggg 1080agtggaggca tcaagggagg atttgttcat caaagaatgg
catccaaaat tggaaggtgg 1140tactctcgaa caatgtctaa aaccaaaagg
atgggaatgg gactgtatgt caagtatgat 1200ggagacccat ggactgacag
tgatgccctt gctcttagtg gagtaatggt ttcaatggaa 1260gaacctggtt
ggtactcatt tggcttcgaa ataaaagata agaaatgtga tgtcccctgt
1320attgggatag agatggtaca tgatggtgga aaggagactt ggcactcagc
agcaacagcc 1380atttactgtt taatgggctc aggacaactg ttgtgggaca
ctgtcacagg tgttgatatg 1440gctctgtaat gggggaatgg ttgagtctgt
tctaaaccct ttgttcctat tttgtttgaa 1500caattgtcct tgctgaactt
aattgtttct gaaaaa 1536471846DNAinfluenza B virus 47tctaatatcc
acaaaatgaa ggcaataatt gtactactca tggtagtaac atccaacgca 60gatcgaatct
gcactgggat aacatcttca aactcacctc atgtggtcaa aacagctact
120caaggggagg tcaatgtgac tggtgtgata ccactgacaa caactccaat
aaaatctcat 180tttgcaaatc tcaaaggaac aaggactaga gggaaactat
gcccagattg tctcaactgc 240acagatctgg atgtggcctt gggcagacca
atgtgtgtgg ggaccacacc ttcggcaaaa 300gcttcaatac tccacgaagt
cagacctgtt acatccgggt gctttcctat aatgcacgac 360agaacaaaaa
tcagacaact acccaatctt ctcagaggat atgaaaatat caggttatca
420acccaaaacg ttatcgatgc agaaaaggcc ctaggaggac cctacagact
tggaacctca 480ggatcttgcc ctaacgccac cagtaaaagc ggatttttcg
caacaatggc ttgggctgtc 540ccaaaggaca acaacaaaaa tgcaacgaac
ccactaacag tagaagtacc atacatctgt 600acagaagggg aagaccaaat
tactgtttgg gggttccatt cagatgacaa aacccaaatg 660aaaaacctct
atggagactc aaatcctcaa aagttcacct catctgctaa tggagtaacc
720acacattatg tttctcagat tggcggcttc ccagatcaaa cagaagacgg
aggactacca 780caaagcggca gaattgttgt tgattacatg gtgcaaaaac
ctgggaaaac aggaacaatt 840gtctatcaaa gaggtgtttt gttgcctcaa
aaggtgtggt gcgcgagtgg caggagcaaa 900gtaataaaag ggtccttgcc
tttaattggt gaagcagatt gccttcatga aaaatacggt 960gggttaaaca
aaagcaagcc ttactacaca ggagaacatg caaaagccat aggaaattgc
1020ccaatatggg tgaaaacacc tttgaagctt gccaatggaa ccaaatatag
acctcctgca 1080aaactattaa aggaaagggg tttcttcgga gctattgctg
gtttcctaga aggaggatgg 1140gaaggaatga ttgcaggttg gcacggatac
acatctcacg gagcacatgg agtggcagtg 1200gcggcagacc ttaagagtac
gcaagaagct ataaacaaga taacaaaaaa tctcaattct 1260ttgagtgagc
tagaagtaaa gaatcttcaa agactaagtg gtgccatgga tgaactccac
1320aacgaaatac tcgagctgga tgagaaagtg gatgatctca gagctgacac
tataagctcg 1380caaatagaac ttgcagtctt gctttccaac gaaggaataa
taaacagtga agatgagcat 1440ctattggcac ttgagagaaa actaaagaaa
atgctgggtc cctctgctgt agacatagga 1500aatggatgct tcgaaaccaa
acacaagtgc aaccagacct gcttagacag gatagctgct 1560ggcaccttta
atgcaggaga attttctctc cccacttttg attcactgaa cattactgct
1620gcatctttaa atgatgatgg attggataac catactatat tgctctatta
ctcaactgct 1680gcttctagtt tggctgtaac attgatgcta gctattttta
ttgtttatat ggtctccaga 1740gacaacgttt catgctccat ctgtctataa
gggagattaa gccttgtatt ttcctttatt 1800gtagtgcttg tttgcttgtc
atcattacaa agaaacgtta ttgaaa 1846481520DNAinfluenza B virus
48ctcaaaactg aggcaaatag gccaaaaatg aacaatgcta ccctcaacta tacaaacgtt
60aaccctattc ctcacatcag ggggagtgtt attatcacta tatgtgtcag cttcactgtc
120atacttacta tattcggata tattgctaaa attttcaaca acagaaataa
ctgcaccaac 180aatgccattg gattgtgcaa acgcatcaaa tgttcaggct
gtgaaccgtt ctgcaacaaa 240aggggtgaca cttcttctcc cagaaccgga
gtggacatac ccgcgtttat cttgcccggg 300ctcaaccttt cagaaagcac
tcctaattag ccctcataga ttcggagaaa ccaaaggaaa 360ctcagctccc
ttgataataa gggaaccttt tattgcttgt ggaccaaagg aatgcaaaca
420ctttgctcta acccattatg cagcccaacc agggggatac tacaatggaa
caagagaaga 480caggaacaag ctgaggcatc taatttcagt caaattgggc
aaaatcccaa cagtagaaaa 540ctccattttc cacatggcag catggagcgg
gtccgcatgc catgatggta aagaatggac 600atatatcgga gttgatggcc
ctgacagtaa tgcattgctc aaaataaaat atggagaagc 660atatactgac
acataccatt cctatgcaaa caacatccta agaacacaag aaagtgcctg
720caattgcatc gggggaaatt gttatcttat gataactgat ggctcagctt
caggtattag 780tgagtgcaga tttcttaaga ttcgagaggg ccgaataata
aaagaaatat ttccaacagg 840aagagtaaaa catactgaag aatgcacatg
cggatttgcc agcaataaaa ccatagaatg 900tgcctgtagg gataacagtt
acacagcaaa aagacccttt gtcaaattaa atgtggagac 960tgatacagca
gaaataagat tgatgtgcac agagacttat ttggacaccc ccagaccaga
1020tgatggaagc ataacagggc cttgtgaatc taatgggaat aaagggagtg
gaggcatcaa 1080gggaggattt gttcatcaaa gaatggcatc caaaattgga
aggtggtact ctcgaacaat 1140gtctaaaacc aaaaggatgg gaatgggact
gtatgtcaag tatgatggag acccatggat 1200tgacagtgat gcccttgctc
ttagtggagt aatggtttca atggaagaac ctggttggta 1260ctcatttggc
ttcgaaataa aagataagaa atgtgatgtc ccctgtattg ggatagagat
1320ggtacatgat ggtggaaagg agacttggca ctcagcagca acagccattt
actgtttaat 1380gggctcagga cagctgctgt gggacactgt cacaggtgtt
gatatggctc tgtaatggag 1440gaatggttga gtctgttcta aaccctttgt
tcctattttg tttgaacaat tgtccttact 1500gaacttaatt gtttctgaaa
152049566PRTinfluenza A virus 49Met Lys Thr Ile Ile Ala Leu Ser Tyr
Ile Leu Cys Leu Val Phe Ala1 5 10 15Gln Lys Leu Pro Gly Asn Asp Asn
Ser Thr Ala Thr Leu Cys Leu Gly20 25 30His His Ala Val Pro Asn Gly
Thr Leu Val Lys Thr Ile Thr Asn Asp35 40 45Gln Ile Glu Val Thr Asn
Ala Thr Glu Leu Val Gln Ser Ser Ser Thr50 55 60Gly Arg Ile Cys Gly
Ser Pro His Arg Ile Leu Asp Gly Lys Asn Cys65 70 75 80Thr Leu Ile
Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln85 90 95Asn Lys
Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn100 105
110Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu
Val115 120 125Ala Ser Ser Gly Thr Leu Glu Phe Ile Asn Glu Asp Phe
Asn Trp Thr130 135 140Gly Val Ala Gln Asp Gly Gly Ser Tyr Ala Cys
Lys Arg Gly Ser Val145 150 155 160Asn Ser Phe Phe Ser Arg Leu Asn
Trp Leu His Lys Leu Glu Tyr Lys165 170 175Tyr Pro Ala Leu Asn Val
Thr Met Pro Asn Asn Gly Lys Phe Asp Lys180 185 190Leu Tyr Ile Trp
Gly Val His His Pro Ser Thr Asp Ser Asp Gln Thr195 200 205Ser Leu
Tyr Val Arg Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg210 215
220Ser Gln Gln Thr Val Thr Pro Asn Ile Gly Ser Arg Pro Trp Val
Arg225 230 235 240Gly Gln Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile
Val Lys Pro Gly245 250 255Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn
Leu Ile Ala Pro Arg Gly260 265 270Tyr Phe Lys Ile Arg Asn Gly Lys
Ser Ser Ile Met Arg Ser Asp Ala275 280 285Pro Ile Gly Asn Cys Ser
Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile290 295 300Pro Asn Asp Lys
Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala305 310 315 320Cys
Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met325 330
335Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile
Ala340 345 350Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly
Trp Tyr Gly355 360 365Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln
Ala Ala Asp Leu Lys370 375 380Ser Thr Gln Ala Ala Ile Asp Gln Ile
Asn Gly Lys Leu Asn Arg Leu385 390 395 400Ile Glu Lys Thr Asn Glu
Lys Phe His Gln Ile Glu Lys Glu Phe Ser405 410 415Glu Val Glu Gly
Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr420 425 430Lys Ile
Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu435 440
445Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu
Phe450 455 460Glu Lys Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp
Met Gly Asn465 470 475 480Gly Cys Phe Lys Ile Tyr His Lys Cys Asp
Asn Ala Cys Ile Gly Ser485 490 495Ile Arg Asn Gly Thr Tyr Asp His
Asp Val Tyr Arg Asp Glu Ala Leu500 505 510Asn Asn Arg Phe Gln Ile
Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys515 520 525Asp Trp Ile Leu
Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys530 535 540Val Val
Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile545 550 555
560Arg Cys Asn Ile Cys Ile56550436PRTinfluenza A virus 50Met Gln
Ile Ala Ile Leu Val Thr Thr Val Thr Leu His Phe Lys Gln1 5 10 15Tyr
Glu Cys Asn Ser Pro Pro Asn Asn Gln Val Met Leu Cys Glu Pro20 25
30Thr Ile Ile Glu Arg Asn Ile Thr Glu Ile Val Tyr Leu Thr Asn Thr35
40 45Thr Ile Glu Lys Glu Ile Cys Pro Lys Leu Ala Glu Tyr Arg Asn
Trp50 55 60Ser Lys Pro Gln Cys Lys Ile Thr Gly Phe Ala Pro Phe Ser
Lys Asp65 70 75 80Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp
Val Thr Arg Glu85 90 95Pro Tyr Val Ser Cys Asp Pro Gly Lys Cys Tyr
Gln Phe Ala Leu Gly100 105 110Gln Gly Thr Thr Leu Asn Asn Arg His
Ser Asn Asp Thr Val His Asp115 120 125Arg Thr Pro Tyr Arg Thr Leu
Leu Met Asn Glu Leu Gly Val Pro Phe130 135 140His Leu Gly Thr Lys
Gln Val Cys Ile Ala Trp Ser Ser Ser Ser Cys145 150 155 160His Asp
Gly Lys Ala Trp Leu His Val Cys Val Thr Gly His Asp Glu165 170
175Asn Ala Thr Ala Ser Phe Ile Tyr Asp Gly Arg Leu Val Asp Ser
Ile180 185 190Gly Ser Trp Ser Lys Asn Ile Leu Arg Thr Gln Glu Ser
Glu Cys Val195 200 205Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr
Asp Gly Ser Ala Ser210 215 220Glu Arg Ala Asp Thr Lys Ile Leu Phe
Ile Glu Glu Gly Lys Ile Val225 230 235 240His Ile Ser Pro Leu Ser
Gly Ser Ala Gln His Val Glu Glu Cys Ser245 250 255Cys Tyr Pro Arg
Tyr Pro Gly Val Arg Cys Val Cys Arg Asp Asn Trp260 265 270Lys Gly
Ser Asn Arg Pro Ile Val Asp Ile Asn Val Lys Asp Tyr Ser275 280
285Ile Val Ser Ser Tyr Val Cys Ser Gly Leu Val Gly Asp Thr Pro
Arg290 295 300Lys Asn Asp Ser Ser Ser Ser Ser Tyr Cys Arg Asn Pro
Asn Asn Glu305 310 315 320Lys Gly Ser His Gly Val Lys Gly Trp Ala
Phe Asp Asp Gly Asn Asp325 330 335Val Trp Met Gly Arg Thr Ile Ser
Glu Glu Leu Arg Ser Gly Tyr Glu340 345 350Thr Phe Lys Val Ile Gly
Gly Trp Ser Lys Pro Asn Ser Lys Leu Gln355 360 365Ile Asn Arg Gln
Val Ile Val Asp Arg Gly Asn Arg Ser Gly Tyr Ser370 375 380Gly Ile
Phe Ser Val Glu Gly Lys Ser Cys Ile Asn Arg Cys Phe Tyr385 390 395
400Val Glu Leu Ile Arg Gly Arg Lys Gln Glu Thr Glu Val Trp Trp
Thr405 410 415Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly Thr
Tyr Gly Thr420 425 430Gly Ser Trp Pro43551566PRTinfluenza A virus
51Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala1
5 10 15Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu
Gly20 25 30His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr
Asn Asp35 40 45Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser
Ser Pro Thr50 55 60Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp
Gly Lys Asn Cys65 70 75 80Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro
His Cys Asp Gly Phe Gln85 90 95Asn Lys Glu Trp Asp Leu Phe Val Glu
Arg Ser Lys Ala Tyr Ser Asn100 105 110Cys Tyr Pro Tyr Asp Val Pro
Asp Tyr Ala Ser Leu Arg Ser Leu Val115 120 125Ala Ser Ser Gly Thr
Leu Glu Phe Ile Asn Glu Asn Phe Asn Trp Thr130 135 140Gly Val Ala
Gln Asp Gly Lys Ser Tyr Ala Cys Lys Arg Gly Ser Val145 150 155
160Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu His Lys Leu Glu Tyr
Lys165 170 175Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Gly Lys
Phe Asp Lys180 185 190Leu Tyr Ile Trp Gly Val His His Pro Ser Thr
Asp Ser Val Gln Thr195 200 205Ser Leu Tyr Val Arg Ala Ser Gly Arg
Val Thr Val Ser Thr Lys Arg210 215 220Ser Gln Gln Thr Val Ile Pro
Asp Ile Gly Tyr Arg Pro Trp Val Arg225 230 235 240Gly Gln Ser Ser
Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly245 250 255Asp Ile
Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly260 265
270Tyr Phe Lys Ile Arg Asn Gly Lys Ser Ser Ile Met Arg Ser Asp
Ala275 280 285Pro Ile Gly Asn Cys Ser Ser Glu Cys Ile Thr Pro Asn
Gly Ser Ile290 295 300Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg
Ile Thr Tyr Gly Ala305 310 315 320Cys Pro Arg Tyr Val Lys Gln Asn
Thr Leu Lys Leu Ala Thr Gly Met325 330 335Arg Asn Val Pro Glu Lys
Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala340 345 350Gly Phe Ile Glu
Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly355 360 365Phe Arg
His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys370 375
380Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg
Leu385 390 395 400Val Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu
Lys Glu Phe Ser405 410 415Glu Val Glu Gly Arg Ile Gln Asp Leu Glu
Lys Tyr Val Glu Asp Thr420 425 430Lys Ile Asp Leu Trp Ser Tyr Asn
Ala Glu Leu Leu Val Ala Leu Glu435 440 445Asn Gln His Thr Ile Asp
Leu Thr Asp Ser Glu Met Asn Lys Leu Phe450 455 460Glu Arg Thr Arg
Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn465 470 475 480Gly
Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser485 490
495Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala
Leu500 505 510Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser
Gly Tyr Lys515 520 525Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser
Cys Phe Leu Leu Cys530 535 540Val Val Leu Leu Gly Phe Ile Met Trp
Ala Cys Gln Lys Gly Asn Ile545 550 555 560Arg Cys Asn Ile Cys
Ile56552451PRTinfluenza A virus 52Lys Met Asn Pro Asn Gln Lys Ile
Ile Thr Ile Gly Ser Val Ser Leu1 5 10 15Thr Ile Ala Thr
Ile Cys Phe Leu Met Gln Ile Ala Ile Leu Val Thr20 25 30Thr Val Thr
Leu His Phe Lys Gln Tyr Glu Cys Asn Ser Pro Pro Asn35 40 45Asn Gln
Val Met Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr50 55 60Glu
Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro65 70 75
80Lys Leu Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Lys Ile Thr85
90 95Gly Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala
Gly100 105 110Gly Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys
Asp Pro Gly115 120 125Lys Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr
Thr Leu Asn Asn Arg130 135 140His Ser Asn Asp Thr Val His Asp Arg
Thr Pro Tyr Arg Thr Leu Leu145 150 155 160Met Asn Glu Leu Gly Val
Pro Phe His Leu Gly Thr Lys Gln Val Cys165 170 175Ile Ala Trp Ser
Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His180 185 190Val Cys
Val Thr Gly His Asp Glu Asn Ala Thr Ala Ser Phe Ile Tyr195 200
205Asp Gly Arg Leu Val Asp Ser Ile Gly Ser Trp Ser Lys Asn Ile
Leu210 215 220Arg Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr
Cys Thr Val225 230 235 240Val Met Thr Asp Gly Ser Ala Ser Glu Arg
Ala Asp Thr Lys Ile Leu245 250 255Phe Ile Glu Glu Gly Lys Ile Val
His Ile Ser Pro Leu Ser Gly Ser260 265 270Ala Gln His Val Glu Glu
Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val275 280 285Arg Cys Val Cys
Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val290 295 300Asp Ile
Asn Val Lys Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser305 310 315
320Gly Leu Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser
Ser325 330 335Tyr Cys Trp Asn Pro Asn Asn Glu Lys Gly Gly His Gly
Val Lys Gly340 345 350Trp Ala Phe Asp Asp Gly Asn Asp Val Trp Met
Gly Arg Thr Ile Ser355 360 365Glu Glu Leu Arg Ser Gly Tyr Glu Thr
Phe Lys Val Ile Gly Gly Trp370 375 380Ser Lys Pro Asn Ser Lys Leu
Gln Ile Asn Arg Gln Val Ile Val Asp385 390 395 400Arg Gly Asn Arg
Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys405 410 415Ser Cys
Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys420 425
430Gln Glu Thr Glu Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe
Cys435 440 445Gly Thr Ser45053566PRTinfluenza A virus 53Met Lys Thr
Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala1 5 10 15Gln Lys
Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly20 25 30His
His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp35 40
45Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr50
55 60Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Lys Asn
Cys65 70 75 80Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp
Gly Phe Gln85 90 95Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Lys
Ala Tyr Ser Asn100 105 110Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
Ser Leu Arg Ser Leu Val115 120 125Ala Ser Ser Gly Thr Leu Glu Phe
Thr Asn Glu Gly Phe Asn Trp Thr130 135 140Gly Val Ala Gln Asp Gly
Thr Ser Tyr Ala Cys Lys Arg Gly Ser Val145 150 155 160Lys Ser Phe
Phe Ser Arg Leu Asn Trp Leu His Lys Leu Glu Tyr Lys165 170 175Tyr
Pro Ala Leu Asn Val Thr Met Pro Asn Asn Asp Lys Phe Asp Lys180 185
190Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser Asp Gln
Thr195 200 205Ser Ile Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser
Thr Lys Arg210 215 220Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser
Arg Pro Trp Val Arg225 230 235 240Gly Ile Ser Ser Arg Ile Ser Ile
Tyr Trp Thr Ile Val Lys Pro Gly245 250 255Asp Ile Leu Leu Ile Asn
Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly260 265 270Tyr Phe Lys Ile
Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala275 280 285Pro Ile
Gly Asn Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile290 295
300Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly
Ala305 310 315 320Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu
Ala Thr Gly Met325 330 335Arg Asn Val Pro Glu Lys Gln Thr Arg Gly
Ile Phe Gly Ala Ile Ala340 345 350Gly Phe Ile Glu Asn Gly Trp Glu
Gly Met Val Asp Gly Trp Tyr Gly355 360 365Phe Arg His Gln Asn Ser
Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys370 375 380Ser Thr Gln Ala
Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu385 390 395 400Ile
Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser405 410
415Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp
Thr420 425 430Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val
Ala Leu Glu435 440 445Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu
Met Asn Lys Leu Phe450 455 460Glu Arg Thr Arg Lys Gln Leu Arg Glu
Asn Ala Glu Asp Met Gly Asn465 470 475 480Gly Cys Phe Lys Ile Tyr
His Lys Cys Asp Asn Ala Cys Ile Gly Ser485 490 495Ile Arg Asn Gly
Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu500 505 510Asn Asn
Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys515 520
525Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu
Cys530 535 540Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys
Gly Asn Ile545 550 555 560Arg Cys Asn Ile Cys
Ile56554469PRTinfluenza A virus 54Met Asn Pro Asn Gln Lys Ile Ile
Thr Ile Gly Ser Val Ser Leu Thr1 5 10 15Ile Ala Thr Ile Cys Phe Leu
Met Gln Ile Ala Ile Leu Val Thr Thr20 25 30Val Thr Leu His Phe Lys
Gln Tyr Glu Cys Asn Ser Pro Pro Asn Asn35 40 45Gln Val Met Leu Cys
Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu50 55 60Ile Val Tyr Leu
Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys65 70 75 80Leu Ala
Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Lys Ile Thr Gly85 90 95Phe
Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly100 105
110Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp
Lys115 120 125Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn
Asn Arg His130 135 140Ser Asn Asp Thr Val His Asp Arg Thr Pro Tyr
Arg Thr Leu Leu Met145 150 155 160Asn Glu Leu Gly Val Pro Phe His
Leu Gly Thr Lys Gln Val Cys Ile165 170 175Ala Trp Ser Ser Ser Ser
Cys His Asp Gly Lys Ala Trp Leu His Val180 185 190Cys Val Thr Gly
His Asp Glu Asn Ala Thr Ala Ser Phe Ile Tyr Asp195 200 205Gly Arg
Leu Val Asp Ser Ile Gly Ser Trp Ser Lys Lys Ile Leu Arg210 215
220Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val
Val225 230 235 240Met Thr Asp Gly Ser Ala Ser Gly Arg Ala Asp Thr
Lys Ile Leu Phe245 250 255Ile Glu Glu Gly Lys Ile Val His Ile Ser
Pro Leu Ser Gly Ser Ala260 265 270Gln His Val Glu Glu Cys Ser Cys
Tyr Pro Arg Tyr Ser Gly Val Arg275 280 285Cys Val Cys Arg Asp Asn
Trp Lys Gly Ser Asn Arg Pro Ile Val Asp290 295 300Ile Asn Val Lys
Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly305 310 315 320Leu
Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His325 330
335Cys Leu Asn Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly
Trp340 345 350Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr
Ile Ser Glu355 360 365Lys Leu Arg Ser Gly Tyr Glu Thr Phe Lys Val
Ile Gly Gly Trp Ser370 375 380Lys Pro Asn Ser Lys Leu Gln Ile Asn
Arg Gln Val Ile Val Asp Arg385 390 395 400Gly Asn Arg Ser Gly Tyr
Ser Gly Ile Phe Ser Val Glu Gly Lys Ser405 410 415Cys Ile Asn Arg
Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln420 425 430Glu Thr
Glu Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly435 440
445Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp
Ile450 455 460Asn Leu Met Pro Ile46555566PRTinfluenza A virus 55Met
Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala1 5 10
15Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly20
25 30His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn
Asp35 40 45Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser
Ser Thr50 55 60Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly
Glu Asn Cys65 70 75 80Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His
Cys Asp Gly Phe Gln85 90 95Asn Lys Glu Trp Asp Leu Phe Val Glu Arg
Ser Lys Ala Tyr Ser Asn100 105 110Cys Tyr Pro Tyr Asp Val Pro Asp
Tyr Ala Ser Leu Arg Ser Leu Val115 120 125Ala Ser Ser Gly Thr Leu
Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr130 135 140Gly Val Ala Gln
Asn Gly Thr Ser Tyr Ala Cys Lys Arg Ser Ser Ile145 150 155 160Lys
Ser Phe Phe Ser Arg Leu Asn Trp Leu His Gln Leu Lys Tyr Lys165 170
175Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Asp Lys Phe Asp
Lys180 185 190Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser
Asp Gln Thr195 200 205Ser Ile Tyr Ala Gln Ala Ser Gly Arg Val Thr
Val Ser Thr Lys Arg210 215 220Ser Gln Gln Thr Val Ile Pro Asn Ile
Gly Ser Arg Pro Trp Val Arg225 230 235 240Gly Ile Ser Ser Arg Ile
Ser Ile His Trp Thr Ile Val Lys Pro Gly245 250 255Asp Ile Leu Leu
Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly260 265 270Tyr Phe
Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala275 280
285Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser
Ile290 295 300Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr
Tyr Gly Ala305 310 315 320Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu
Lys Leu Ala Thr Gly Met325 330 335Arg Asn Val Pro Glu Lys Gln Thr
Arg Gly Ile Phe Gly Ala Ile Ala340 345 350Gly Phe Ile Glu Asn Gly
Trp Glu Gly Met Val Asp Gly Trp Tyr Gly355 360 365Phe Arg His Gln
Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys370 375 380Ser Thr
Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu385 390 395
400Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe
Ser405 410 415Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val
Glu Asp Thr420 425 430Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu
Leu Val Ala Leu Glu435 440 445Asn Gln His Thr Ile Asp Leu Thr Asp
Ser Glu Met Asn Lys Leu Phe450 455 460Glu Arg Thr Arg Lys Gln Leu
Arg Glu Asn Ala Glu Asp Met Gly Asn465 470 475 480Gly Cys Phe Lys
Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser485 490 495Ile Arg
Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu500 505
510Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr
Lys515 520 525Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe
Leu Leu Cys530 535 540Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys
Gln Lys Gly Asn Ile545 550 555 560Arg Cys Asn Ile Cys
Ile56556469PRTinfluenza A virus 56Met Asn Pro Asn Gln Lys Ile Ile
Thr Ile Gly Ser Val Ser Leu Thr1 5 10 15Ile Ala Thr Ile Cys Phe Leu
Met Gln Ile Ala Ile Leu Val Thr Thr20 25 30Val Thr Leu His Phe Lys
Gln Tyr Glu Cys Ser Ser Pro Pro Asn Asn35 40 45Gln Val Met Leu Cys
Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu50 55 60Ile Val Tyr Leu
Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys65 70 75 80Leu Ala
Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Lys Ile Thr Gly85 90 95Phe
Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly100 105
110Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp
Lys115 120 125Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn
Asn Arg His130 135 140Ser Asn Asp Thr Val His Asp Arg Thr Pro Tyr
Arg Thr Leu Leu Met145 150 155 160Asn Glu Leu Gly Val Pro Phe His
Leu Gly Thr Lys Gln Val Cys Ile165 170 175Ala Trp Ser Ser Ser Ser
Cys His Asp Gly Lys Ala Trp Leu His Val180 185 190Cys Val Thr Gly
His Asp Glu Asn Ala Thr Ala Ser Phe Ile Tyr Asp195 200 205Gly Arg
Leu Val Asp Ser Ile Gly Ser Trp Ser Lys Lys Ile Leu Arg210 215
220Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val
Val225 230 235 240Met Thr Asp Gly Ser Ala Ser Gly Arg Ala Asp Thr
Lys Ile Leu Phe245 250 255Ile Glu Glu Gly Lys Ile Val His Ile Ser
Pro Leu Ser Gly Ser Ala260 265 270Gln His Val Glu Glu Cys Ser Cys
Tyr Pro Arg Tyr Pro Gly Val Arg275 280 285Cys Val Cys Arg Asp Asn
Trp Lys Gly Ser Asn Arg Pro Ile Val Asp290 295 300Ile Asn Val Lys
Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly305 310 315 320Leu
Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His325 330
335Cys Leu Asn Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly
Trp340 345 350Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr
Ile Ser Glu355 360 365Lys Phe Arg Ser Gly Tyr Glu Thr Phe Lys Val
Ile Glu Gly Trp Ser370 375 380Lys Pro Asn Ser Lys Leu Gln Ile Asn
Arg Gln Val Ile Val Asp Arg385 390 395 400Gly Asn Arg Ser Gly Tyr
Ser Gly Ile Phe Ser Val Glu Gly Lys Ser405 410 415Cys Ile Asn Arg
Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln420 425 430Glu Thr
Glu Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly435 440
445Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp
Ile450 455 460Asn Leu Met Pro Ile46557566PRTinfluenza A virus 57Met
Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala1 5 10
15Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly20
25 30His His Ala Val Ser Asn Gly Thr Leu Val Lys Thr Ile Thr Asn
Asp35 40 45Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser
Ser Thr50 55 60Gly Arg Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly
Glu Asn Cys65 70 75 80Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His
Cys Asp Gly Phe Gln85 90 95Asn Lys Glu Trp Asp Leu Phe Val Glu Arg
Ser Lys Ala Tyr Ser Asn100 105 110Cys Tyr Pro Tyr Asp Val Pro Asp
Tyr Ala Ser Leu Arg Ser Leu Val115 120 125Ala Ser Ser Gly Thr Leu
Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr130 135 140Gly Val Ala Gln
Asn Gly Thr
Ser Ser Ala Cys Lys Arg Gly Ser Asn145 150 155 160Lys Ser Phe Phe
Ser Arg Leu Asn Trp Leu His Gln Leu Lys Tyr Lys165 170 175Tyr Pro
Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys180 185
190Leu Tyr Ile Trp Gly Val Leu His Pro Ser Thr Asp Ser Asp Gln
Ile195 200 205Ser Leu Tyr Ala Gln Ala Ser Gly Arg Val Thr Val Ser
Thr Lys Arg210 215 220Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser
Arg Pro Trp Val Arg225 230 235 240Gly Val Ser Ser Arg Ile Ser Ile
Tyr Trp Thr Ile Val Lys Pro Gly245 250 255Asp Ile Leu Leu Ile Asn
Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly260 265 270Tyr Phe Lys Ile
Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala275 280 285Pro Ile
Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile290 295
300Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly
Ala305 310 315 320Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu
Ala Thr Gly Met325 330 335Arg Asn Val Pro Glu Lys Gln Thr Arg Gly
Ile Phe Gly Ala Ile Ala340 345 350Gly Phe Ile Glu Asn Gly Trp Glu
Gly Met Val Asp Gly Trp Tyr Gly355 360 365Phe Arg His Gln Asn Ser
Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys370 375 380Ser Thr Gln Ala
Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu385 390 395 400Ile
Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser405 410
415Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp
Thr420 425 430Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val
Ala Leu Glu435 440 445Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu
Met Asn Lys Leu Phe450 455 460Glu Arg Thr Lys Lys Gln Leu Arg Glu
Asn Ala Glu Asp Met Gly Asn465 470 475 480Gly Cys Phe Lys Ile Tyr
His Lys Cys Asp Asn Ala Cys Ile Gly Ser485 490 495Ile Arg Asn Gly
Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu500 505 510Asn Asn
Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys515 520
525Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu
Cys530 535 540Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys
Gly Asn Ile545 550 555 560Arg Cys Asn Ile Cys
Ile56558469PRTinfluenza A virus 58Met Asn Pro Asn Gln Lys Ile Ile
Thr Ile Gly Ser Val Ser Leu Thr1 5 10 15Ile Ala Thr Ile Cys Phe Leu
Met Gln Ile Ala Ile Leu Val Thr Thr20 25 30Val Thr Leu His Phe Lys
Gln Tyr Glu Cys Asn Ser Pro Pro Asn Asn35 40 45Gln Val Met Leu Cys
Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu50 55 60Ile Val Tyr Leu
Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys65 70 75 80Leu Ala
Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Lys Ile Thr Gly85 90 95Phe
Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly100 105
110Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp
Lys115 120 125Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn
Asn Arg His130 135 140Ser Asn Asp Thr Val His Asp Arg Thr Pro Tyr
Arg Thr Leu Leu Met145 150 155 160Asn Glu Leu Gly Val Pro Phe His
Leu Gly Thr Lys Gln Val Cys Ile165 170 175Ala Trp Ser Ser Ser Ser
Cys His Asp Gly Lys Ala Trp Leu His Val180 185 190Cys Val Thr Gly
His Asp Glu Asn Ala Thr Ala Ser Phe Ile Tyr Asp195 200 205Gly Arg
Leu Val Asp Ser Ile Gly Ser Trp Ser Lys Lys Ile Leu Arg210 215
220Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val
Val225 230 235 240Met Thr Asp Gly Ser Ala Ser Gly Arg Ala Asp Thr
Lys Ile Leu Phe245 250 255Ile Glu Glu Gly Lys Ile Val His Thr Ser
Lys Leu Ser Gly Ser Ala260 265 270Gln His Val Glu Glu Cys Ser Cys
Tyr Pro Arg Tyr Pro Gly Val Arg275 280 285Cys Val Cys Arg Asp Asn
Trp Lys Gly Ser Asn Arg Pro Ile Val Asp290 295 300Ile Asn Val Lys
Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly305 310 315 320Leu
Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His325 330
335Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly
Trp340 345 350Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr
Ile Ser Glu355 360 365Lys Ser Arg Ser Gly Tyr Glu Thr Phe Lys Val
Ile Glu Gly Trp Ser370 375 380Lys Pro Asn Ser Lys Leu Gln Ile Asn
Arg Gln Val Ile Val Glu Arg385 390 395 400Gly Asn Met Ser Gly Tyr
Ser Gly Ile Phe Ser Val Glu Gly Lys Ser405 410 415Cys Ile Asn Arg
Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln420 425 430Glu Thr
Glu Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly435 440
445Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp
Ile450 455 460Asn Leu Met Pro Ile46559566PRTinfluenza A virus 59Met
Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ser1 5 10
15Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly20
25 30His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn
Asp35 40 45Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser
Ser Thr50 55 60Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly
Glu Asn Cys65 70 75 80Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln
Cys Asp Gly Phe Gln85 90 95Asn Lys Lys Trp Asp Leu Phe Val Glu Arg
Ser Lys Ala Tyr Ser Asn100 105 110Cys Tyr Pro Tyr Asp Val Pro Asp
Tyr Ala Ser Leu Arg Ser Leu Val115 120 125Ala Ser Ser Gly Thr Leu
Glu Phe Asn Asn Glu Ser Phe Asn Trp Ala130 135 140Gly Val Thr Gln
Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn145 150 155 160Lys
Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Tyr Lys165 170
175Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp
Lys180 185 190Leu Tyr Ile Trp Gly Val His His Pro Val Thr Asp Ser
Asp Gln Ile195 200 205Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr
Val Ser Thr Lys Arg210 215 220Ser Gln Gln Thr Val Ile Pro Asn Ile
Gly Tyr Arg Pro Arg Val Arg225 230 235 240Asp Ile Ser Ser Arg Ile
Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly245 250 255Asp Ile Leu Leu
Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly260 265 270Tyr Phe
Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala275 280
285Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser
Ile290 295 300Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr
Tyr Gly Ala305 310 315 320Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu
Lys Leu Ala Thr Gly Met325 330 335Arg Asn Val Pro Glu Lys Gln Thr
Arg Gly Ile Phe Gly Ala Ile Ala340 345 350Gly Phe Ile Glu Asn Gly
Trp Glu Gly Met Val Asp Gly Trp Tyr Gly355 360 365Phe Arg His Gln
Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys370 375 380Ser Thr
Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu385 390 395
400Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe
Ser405 410 415Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val
Glu Asp Thr420 425 430Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu
Leu Val Ala Leu Glu435 440 445Asn Gln His Thr Ile Asp Leu Thr Asp
Ser Glu Met Asn Lys Leu Phe450 455 460Glu Arg Thr Lys Lys Gln Leu
Arg Glu Asn Ala Glu Asp Met Gly Asn465 470 475 480Gly Cys Phe Lys
Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Glu Ser485 490 495Ile Arg
Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu500 505
510Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr
Lys515 520 525Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe
Leu Leu Cys530 535 540Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys
Gln Lys Gly Asn Ile545 550 555 560Arg Cys Asn Ile Cys
Ile56560469PRTinfluenza A virus 60Met Asn Pro Asn Gln Lys Ile Ile
Thr Ile Gly Ser Val Ser Leu Thr1 5 10 15Ile Ser Thr Ile Cys Phe Phe
Met Gln Ile Ala Ile Leu Ile Thr Thr20 25 30Val Thr Leu His Phe Lys
Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn35 40 45Gln Val Met Leu Cys
Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu50 55 60Ile Val Tyr Leu
Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys65 70 75 80Leu Ala
Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asn Ile Thr Gly85 90 95Phe
Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly100 105
110Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp
Lys115 120 125Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn
Asn Val His130 135 140Ser Asn Asp Thr Val His Asp Arg Thr Pro Tyr
Arg Thr Leu Leu Met145 150 155 160Asn Glu Leu Gly Val Pro Phe His
Leu Gly Thr Lys Gln Val Cys Ile165 170 175Ala Trp Ser Ser Ser Ser
Cys His Asp Gly Lys Ala Trp Leu His Val180 185 190Cys Val Thr Gly
Asp Asp Glu Asn Ala Thr Ala Ser Phe Ile Tyr Asn195 200 205Gly Arg
Leu Val Asp Ser Ile Val Ser Trp Ser Lys Lys Ile Leu Arg210 215
220Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val
Val225 230 235 240Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr
Lys Ile Leu Phe245 250 255Ile Glu Glu Gly Lys Ile Val His Thr Ser
Thr Leu Ser Gly Ser Ala260 265 270Gln His Val Glu Glu Cys Ser Cys
Tyr Pro Arg Tyr Pro Gly Val Arg275 280 285Cys Val Cys Arg Asp Asn
Trp Lys Gly Ser Asn Arg Pro Ile Val Asp290 295 300Ile Asn Ile Lys
Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly305 310 315 320Leu
Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His325 330
335Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly
Trp340 345 350Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr
Ile Ser Glu355 360 365Lys Leu Arg Ser Gly Tyr Glu Thr Phe Lys Val
Ile Glu Gly Trp Ser370 375 380Asn Pro Asn Ser Lys Leu Gln Ile Asn
Arg Gln Val Ile Val Asp Arg385 390 395 400Gly Asn Arg Ser Gly Tyr
Ser Gly Ile Phe Ser Val Glu Gly Lys Ser405 410 415Cys Ile Asn Arg
Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln420 425 430Glu Thr
Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly435 440
445Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp
Ile450 455 460Asn Leu Met Pro Ile46561566PRTinfluenza A virus 61Met
Lys Ala Lys Leu Leu Val Leu Leu Cys Ala Phe Thr Ala Thr Tyr1 5 10
15Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr20
25 30Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val
Asn35 40 45Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys
Gly Ile50 55 60Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp
Ile Leu Gly65 70 75 80Asn Pro Lys Cys Glu Ser Leu Phe Ser Lys Glu
Ser Trp Ser Tyr Ile85 90 95Ala Glu Thr Pro Asn Pro Glu Asn Gly Thr
Cys Tyr Pro Gly Tyr Phe100 105 110Ala Asp Tyr Glu Glu Leu Arg Glu
Gln Leu Ser Ser Val Ser Ser Phe115 120 125Glu Arg Phe Glu Ile Phe
Pro Lys Glu Ser Ser Trp Pro Asn His Thr130 135 140Val Thr Lys Gly
Val Thr Thr Ser Cys Ser His Asn Gly Lys Ser Ser145 150 155 160Phe
Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Asn Gly Leu Tyr Pro165 170
175Asn Val Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu
Val180 185 190Leu Trp Gly Val His His Pro Ser Asn Ile Gly Asp Gln
Arg Ala Ile195 200 205Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val
Ser Ser His Tyr Ser210 215 220Arg Arg Phe Thr Pro Glu Ile Ala Lys
Arg Pro Lys Val Arg Asp Gln225 230 235 240Glu Gly Arg Ile Asn Tyr
Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr245 250 255Ile Ile Phe Glu
Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe260 265 270Ala Leu
Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser275 280
285Met Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile
Asn290 295 300Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile
Gly Glu Cys305 310 315 320Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg
Met Val Thr Gly Leu Arg325 330 335Asn Ile Pro Ser Ile Gln Ser Arg
Gly Leu Phe Gly Ala Ile Ala Gly340 345 350Phe Ile Glu Gly Gly Trp
Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr355 360 365His His Gln Asn
Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser370 375 380Thr Gln
Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile385 390 395
400Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn
Lys405 410 415Leu Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp
Asp Gly Phe420 425 430Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu
Val Leu Leu Glu Asn435 440 445Gly Arg Thr Leu Asp Phe His Asp Ser
Asn Val Lys Asn Leu Tyr Glu450 455 460Lys Val Lys Ser Gln Leu Lys
Asn Asn Ala Lys Glu Ile Gly Asn Gly465 470 475 480Cys Phe Glu Phe
Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val485 490 495Lys Asn
Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu500 505
510Asn Arg Gly Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val
Tyr515 520 525Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu
Val Leu Leu530 535 540Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys
Ser Asn Gly Ser Leu545 550 555 560Gln Cys Arg Ile Cys
Ile56562470PRTinfluenza A virus 62Met Asn Pro Asn Gln Lys Ile Ile
Ile Ile Gly Ser Ile Ser Met Ala1 5 10 15Ile Gly Ile Ile Ser Leu Ile
Leu Gln Ile Gly Asn Ile Ile Ser Ile20 25 30Trp Ala Ser His Ser Ile
Gln Thr Gly Ser Gln Asn His Thr Gly Ile35 40 45Cys Asn Gln Arg Ile
Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn Gln50 55 60Thr Tyr Val Asn
Ile Asn Asn Thr Asn Val Val Ala Gly Lys Asp Lys65 70 75 80Thr Ser
Val Thr Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Arg Gly85 90 95Trp
Ala Ile Tyr Thr Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly100 105
110Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu
Glu115 120 125Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn
Asp Lys His130 135 140Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr
Arg Ala Leu Met Ser145 150
155 160Cys Pro Leu Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu
Ser165 170 175Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly
Trp Leu Thr180 185 190Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val
Ala Val Leu Lys Tyr195 200 205Asn Gly Ile Ile Thr Glu Thr Ile Lys
Ser Trp Lys Lys Arg Ile Leu210 215 220Arg Thr Gln Glu Ser Glu Cys
Val Cys Val Asn Gly Ser Cys Phe Thr225 230 235 240Ile Met Thr Asp
Gly Pro Ser Asn Gly Ala Ala Ser Tyr Arg Ile Phe245 250 255Lys Ile
Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asp Ala Pro260 265
270Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Thr
Val275 280 285Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg
Pro Trp Val290 295 300Ser Phe Asn Gln Asn Leu Asp Tyr Gln Ile Gly
Tyr Ile Cys Ser Gly305 310 315 320Val Phe Gly Asp Asn Pro Arg Pro
Lys Asp Gly Glu Gly Ser Cys Asn325 330 335Pro Val Thr Val Asp Gly
Ala Asp Gly Val Lys Gly Phe Ser Tyr Arg340 345 350Tyr Gly Asn Gly
Val Trp Ile Gly Arg Thr Lys Ser Asn Arg Leu Arg355 360 365Lys Gly
Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Asp Thr Asp370 375
380Ser Asp Phe Ser Val Lys Gln Asp Val Val Ala Met Thr Asp Trp
Ser385 390 395 400Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu
Thr Gly Leu Asp405 410 415Cys Met Arg Pro Cys Phe Trp Val Glu Leu
Ile Arg Gly Arg Pro Arg420 425 430Glu Asn Thr Thr Ile Trp Thr Ser
Gly Ser Ser Ile Ser Phe Cys Gly435 440 445Val Asn Ser Asp Thr Ala
Asn Trp Ser Trp Pro Asp Gly Ala Glu Leu450 455 460Pro Phe Thr Ile
Asp Lys465 47063562PRTinfluenza A virus 63Met Lys Ala Lys Leu Leu
Val Leu Leu Cys Ala Phe Thr Ala Thr Tyr1 5 10 15Ala Asp Thr Ile Cys
Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr20 25 30Val Asp Thr Val
Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn35 40 45Leu Leu Glu
Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Thr50 55 60Ala Pro
Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly65 70 75
80Asn Pro Glu Cys Glu Ser Leu Phe Ser Lys Glu Ser Trp Ser Tyr Ile85
90 95Ala Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr
Phe100 105 110Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val
Ser Ser Phe115 120 125Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser
Trp Pro Lys His Thr130 135 140Val Thr Lys Gly Val Thr Ala Ser Cys
Ser His Asn Gly Lys Ser Ser145 150 155 160Phe Tyr Lys Asn Leu Leu
Trp Leu Thr Glu Lys Asn Gly Leu Tyr Pro165 170 175Asn Leu Ser Lys
Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val180 185 190Leu Trp
Gly Val His His Pro Ser Asn Ile Gly Asp Gln Arg Ala Ile195 200
205Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr
Ser210 215 220Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val
Arg Gly Gln225 230 235 240Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu
Leu Glu Pro Gly Asp Thr245 250 255Ile Ile Phe Glu Ala Asn Gly Asn
Leu Ile Ala Pro Trp Tyr Ala Phe260 265 270Ala Leu Ser Arg Gly Phe
Gly Ser Gly Ile Ile Thr Ser Thr Ala Ser275 280 285Met Gly Glu Cys
Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn290 295 300Ser Ser
Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys305 310 315
320Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu
Arg325 330 335Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala
Ile Ala Gly340 345 350Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp
Gly Trp Tyr Gly Tyr355 360 365His His Gln Asn Glu Gln Gly Ser Gly
Tyr Ala Ala Asp Gln Lys Ser370 375 380Thr Gln Asn Ala Ile Asp Gly
Ile Thr Asn Lys Val Asn Ser Val Ile385 390 395 400Glu Lys Met Asn
Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys405 410 415Leu Glu
Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe420 425
430Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu
Asn435 440 445Gly Arg Thr Leu Gly Phe His Asp Ser Asn Val Lys Asn
Leu Tyr Glu450 455 460Lys Val Lys Asn Gln Leu Lys Asn Asn Ala Lys
Glu Ile Gly Asn Gly465 470 475 480Cys Phe Glu Phe Tyr His Lys Cys
Asn Asn Glu Cys Met Glu Ser Val485 490 495Lys Asn Gly Thr Tyr Asp
Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu500 505 510Asn Arg Glu Lys
Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr515 520 525Gln Ile
Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu530 535
540Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser
Leu545 550 555 560Gln Cys64470PRTinfluenza A virus 64Met Asn Pro
Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Ser Ile Ala1 5 10 15Ile Gly
Ile Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile20 25 30Trp
Ala Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile35 40
45Cys Asn Gln Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn Gln50
55 60Thr Tyr Val Asn Ile Asn Asn Thr Asn Val Val Ala Gly Lys Asp
Lys65 70 75 80Thr Ser Met Thr Leu Ala Gly Asn Ser Ser Leu Cys Pro
Ile Arg Gly85 90 95Trp Ala Ile Tyr Thr Lys Asp Asn Ser Ile Arg Ile
Gly Ser Lys Gly100 105 110Asp Val Phe Val Ile Arg Glu Pro Phe Ile
Ser Cys Ser His Leu Glu115 120 125Cys Arg Thr Phe Phe Leu Thr Gln
Gly Ala Leu Leu Asn Asp Lys His130 135 140Ser Asn Gly Thr Val Lys
Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser145 150 155 160Cys Pro Leu
Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser165 170 175Val
Ala Trp Ser Ala Ser Ala Cys His Asp Gly Leu Gly Trp Leu Thr180 185
190Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys
Tyr195 200 205Asn Gly Ile Ile Thr Glu Thr Ile Lys Ser Trp Lys Lys
Arg Ile Leu210 215 220Arg Thr Gln Glu Ser Glu Cys Val Cys Met Asn
Gly Ser Cys Phe Thr225 230 235 240Ile Met Thr Asp Gly Pro Ser Asn
Gly Ala Ala Ser Tyr Arg Ile Phe245 250 255Lys Ile Glu Lys Gly Arg
Val Thr Lys Ser Ile Glu Leu Asp Ala Pro260 265 270Asn Tyr His Tyr
Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Thr Val275 280 285Met Cys
Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val290 295
300Ser Phe Asn Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser
Gly305 310 315 320Val Phe Gly Asp Asn Pro Arg Pro Lys Asp Gly Glu
Gly Ser Cys Asn325 330 335Pro Val Thr Val Asp Gly Ala Asp Gly Val
Lys Gly Phe Ser Tyr Arg340 345 350Tyr Gly Asn Gly Val Trp Ile Gly
Arg Thr Lys Ser Asn Arg Leu Arg355 360 365Lys Gly Phe Glu Met Ile
Trp Asp Pro Asn Gly Trp Thr Asp Thr Asp370 375 380Ser Asp Phe Ser
Met Lys Gln Asp Ile Val Ala Met Thr Asp Trp Ser385 390 395 400Gly
Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp405 410
415Cys Met Arg Pro Cys Phe Trp Val Glu Leu Val Arg Gly Leu Pro
Arg420 425 430Glu Asn Thr Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser
Phe Cys Gly435 440 445Val Asn Ser Asp Thr Ala Asn Trp Ser Trp Pro
Asp Gly Ala Glu Leu450 455 460Pro Phe Thr Ile Asp Lys465
47065565PRTinfluenza A virus 65Met Lys Ala Lys Leu Leu Val Leu Leu
Cys Thr Phe Thr Ala Thr Tyr1 5 10 15Ala Asp Thr Ile Cys Ile Gly Tyr
His Ala Asn Asn Ser Thr Asp Thr20 25 30Val Asp Thr Val Leu Glu Lys
Asn Val Thr Val Thr His Ser Val Asn35 40 45Leu Leu Glu Asp Ser His
Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile50 55 60Ala Pro Leu Gln Leu
Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly65 70 75 80Asn Pro Glu
Cys Glu Ser Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile85 90 95Val Glu
Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe100 105
110Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser
Phe115 120 125Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro
Lys His Thr130 135 140Val Thr Gly Val Thr Ala Ser Cys Ser His Asn
Gly Lys Ser Ser Phe145 150 155 160Tyr Arg Asn Leu Leu Trp Leu Thr
Glu Lys Asn Gly Leu Tyr Pro Asn165 170 175Leu Ser Asn Ser Tyr Val
Asn Asn Lys Glu Lys Glu Val Leu Val Leu180 185 190Trp Gly Val His
His Pro Ser Asn Ile Gly Asp Gln Arg Ala Ile Tyr195 200 205His Thr
Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg210 215
220Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Gly Gln
Glu225 230 235 240Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro
Gly Asp Thr Ile245 250 255Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala
Pro Trp Tyr Ala Phe Ala260 265 270Leu Ser Arg Gly Phe Gly Ser Gly
Ile Ile Thr Ser Asn Ala Pro Met275 280 285Asn Glu Cys Asp Ala Lys
Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser290 295 300Ser Leu Pro Phe
Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro305 310 315 320Lys
Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn325 330
335Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly
Phe340 345 350Ile Glu Gly Gly Trp Thr Gly Met Met Asp Gly Trp Tyr
Gly Tyr His355 360 365His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala
Asp Gln Lys Ser Thr370 375 380Gln Asn Ala Ile Asn Gly Ile Thr Asn
Lys Val Asn Ser Val Ile Glu385 390 395 400Lys Met Asn Thr Gln Phe
Thr Ala Val Gly Lys Glu Phe Asn Lys Leu405 410 415Glu Arg Arg Met
Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu420 425 430Asp Ile
Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu435 440
445Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu
Lys450 455 460Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly
Asn Gly Cys465 470 475 480Phe Glu Phe Tyr His Lys Cys Asn Asn Glu
Cys Met Glu Ser Val Lys485 490 495Asn Gly Thr Tyr Asp Tyr Pro Lys
Tyr Ser Glu Glu Ser Lys Leu Asn500 505 510Arg Glu Lys Ile Asp Gly
Val Lys Leu Glu Ser Met Gly Val Tyr Gln515 520 525Ile Leu Ala Ile
Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val530 535 540Ser Leu
Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln545 550 555
560Cys Arg Ile Cys Ile56566470PRTinfluenza A virus 66Met Asn Pro
Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Ser Ile Val1 5 10 15Ile Gly
Ile Ile Ser Leu Met Leu Gln Ile Gly Asn Ile Ile Ser Ile20 25 30Trp
Ala Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile35 40
45Cys Asn Gln Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn His50
55 60Thr Tyr Val Asn Ile Asn Asn Thr Asn Val Val Ala Gly Lys Asp
Lys65 70 75 80Thr Ser Val Thr Leu Ala Gly Asn Ser Ser Leu Cys Ser
Ile Ser Gly85 90 95Trp Ala Ile Tyr Thr Lys Asp Asn Ser Ile Arg Ile
Gly Ser Lys Gly100 105 110Asp Val Phe Val Ile Arg Glu Pro Phe Ile
Ser Cys Ser His Leu Glu115 120 125Cys Arg Thr Phe Phe Leu Thr Gln
Gly Ala Leu Leu Asn Asp Lys His130 135 140Ser Asn Gly Thr Val Lys
Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser145 150 155 160Cys Pro Leu
Gly Glu Ala Pro Ser Pro Tyr Asn Ser Lys Phe Glu Ser165 170 175Val
Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr180 185
190Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys
Tyr195 200 205Asn Gly Ile Ile Thr Glu Thr Ile Lys Ser Trp Lys Lys
Arg Ile Leu210 215 220Arg Thr Gln Glu Ser Glu Cys Val Cys Val Asn
Gly Ser Cys Phe Thr225 230 235 240Ile Met Thr Asp Gly Pro Ser Asn
Gly Ala Ala Ser Tyr Lys Ile Phe245 250 255Lys Ile Glu Lys Gly Lys
Val Thr Lys Ser Ile Glu Leu Asn Ala Pro260 265 270Asn Ser His Tyr
Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Thr Val275 280 285Met Cys
Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val290 295
300Ser Phe Asn Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser
Gly305 310 315 320Val Phe Gly Asp Asn Pro Arg Pro Lys Asp Gly Glu
Gly Ser Cys Asn325 330 335Pro Val Thr Val Asp Gly Ala Asp Gly Val
Lys Gly Phe Ser Tyr Arg340 345 350Tyr Gly Asn Gly Val Trp Ile Gly
Arg Thr Lys Ser Asn Arg Leu Arg355 360 365Lys Gly Phe Glu Met Ile
Trp Asp Pro Asn Gly Trp Thr Asp Thr Asp370 375 380Ser Asp Phe Ser
Val Lys Gln Asp Val Val Ala Met Thr Asp Trp Ser385 390 395 400Gly
Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp405 410
415Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Val Arg Gly Arg Pro
Arg420 425 430Glu Asn Thr Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser
Phe Cys Gly435 440 445Val Asn Ser Asp Thr Ala Asn Trp Ser Trp Pro
Asp Gly Ala Glu Leu450 455 460Pro Phe Thr Ile Asp Lys465
47067565PRTinfluenza A virus 67Met Lys Ala Lys Leu Leu Val Leu Leu
Cys Thr Phe Thr Ala Thr Tyr1 5 10 15Ala Asp Thr Ile Cys Ile Gly Tyr
His Ala Asn Asn Ser Thr Asp Thr20 25 30Val Asp Thr Val Leu Glu Lys
Asn Val Thr Val Thr His Ser Val Asn35 40 45Leu Leu Glu Asp Ser His
Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile50 55 60Ala Pro Leu Gln Leu
Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly65 70 75 80Asn Pro Glu
Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile85 90 95Val Glu
Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe100 105
110Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser
Phe115 120 125Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro
Lys His Thr130 135 140Val Thr Gly Val Ser Ala Ser Cys Ser His Asn
Gly Lys Asn Ser Phe145 150 155 160Tyr Arg Asn Leu Leu Trp Leu Thr
Gly Lys Asn Gly Leu Tyr Pro Asn165 170 175Leu Ser Lys Ser Tyr Val
Asn Asn Lys Glu Lys Glu Val Leu Val Leu180 185 190Trp Gly Val His
His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr195 200 205His Thr
Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg210 215
220Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln
Glu225 230 235 240Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro
Gly Asp Thr Ile245 250 255Ile Phe Glu Ala Asn Gly Asn
Leu Ile Ala Pro Trp Tyr Ala Phe Ala260 265 270Leu Ser Arg Gly Phe
Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met275 280 285Asp Glu Cys
Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser290 295 300Ser
Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro305 310
315 320Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg
Asn325 330 335Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile
Ala Gly Phe340 345 350Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly
Trp Tyr Gly Tyr His355 360 365His Gln Asn Glu Gln Gly Ser Gly Tyr
Ala Ala Asp Gln Lys Ser Thr370 375 380Gln Asn Ala Ile Asn Gly Ile
Thr Asn Lys Val Asn Ser Val Ile Glu385 390 395 400Lys Met Asn Thr
Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu405 410 415Glu Arg
Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu420 425
430Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn
Glu435 440 445Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu
Tyr Glu Lys450 455 460Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu
Ile Gly Asn Gly Cys465 470 475 480Phe Glu Phe Tyr His Lys Cys Asn
Asn Glu Cys Met Glu Ser Val Lys485 490 495Asn Gly Thr Tyr Asp Tyr
Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn500 505 510Arg Glu Lys Ile
Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln515 520 525Ile Leu
Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val530 535
540Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu
Gln545 550 555 560Cys Arg Ile Cys Ile56568470PRTinfluenza A virus
68Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Ser Ile Ala1
5 10 15Ile Gly Ile Ile Ser Leu Met Leu Gln Ile Gly Asn Ile Ile Ser
Ile20 25 30Trp Ala Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr
Gly Val35 40 45Cys Asn Gln Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp
Val Asn His50 55 60Thr Tyr Val Asn Ile Asn Asn Thr Asn Val Val Ala
Gly Lys Asp Lys65 70 75 80Thr Ser Val Thr Leu Ala Gly Asn Ser Ser
Leu Cys Ser Ile Ser Gly85 90 95Trp Ala Ile Tyr Thr Lys Asp Asn Ser
Ile Arg Ile Gly Ser Lys Gly100 105 110Asp Val Phe Val Ile Arg Glu
Pro Phe Ile Ser Cys Ser His Leu Glu115 120 125Cys Arg Thr Phe Phe
Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His130 135 140Ser Asn Gly
Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser145 150 155
160Cys Pro Leu Gly Glu Ala Pro Ser Pro Tyr Asn Ser Lys Phe Glu
Ser165 170 175Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly
Trp Leu Thr180 185 190Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val
Ala Val Leu Lys Tyr195 200 205Asn Gly Ile Ile Thr Glu Thr Ile Lys
Ser Trp Lys Lys Arg Ile Leu210 215 220Arg Thr Gln Glu Ser Glu Cys
Val Cys Val Asn Gly Ser Cys Phe Thr225 230 235 240Ile Met Thr Asp
Gly Pro Ser Asn Gly Ala Ala Ser Tyr Lys Ile Phe245 250 255Lys Ile
Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala Pro260 265
270Asn Phe His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Thr
Val275 280 285Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg
Pro Trp Val290 295 300Ser Phe Asn Gln Asn Leu Asp Tyr Gln Ile Gly
Tyr Ile Cys Ser Gly305 310 315 320Val Phe Gly Asp Asn Pro Arg Pro
Lys Asp Gly Glu Gly Ser Cys Asn325 330 335Pro Val Thr Val Asp Gly
Ala Asp Gly Val Lys Gly Phe Ser Tyr Lys340 345 350Tyr Gly Asn Gly
Val Trp Ile Gly Arg Thr Lys Ser Asn Arg Leu Arg355 360 365Lys Gly
Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Asp Thr Asp370 375
380Ser Asp Phe Ser Val Lys Gln Asp Val Val Ala Ile Thr Asp Trp
Ser385 390 395 400Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu
Thr Gly Leu Asp405 410 415Cys Ile Arg Pro Cys Phe Trp Val Glu Leu
Val Arg Gly Leu Pro Arg420 425 430Glu Asn Thr Thr Ile Trp Thr Ser
Gly Ser Ser Ile Ser Phe Cys Gly435 440 445Val Asn Ser Asp Thr Ala
Asn Trp Ser Trp Pro Asp Gly Ala Glu Leu450 455 460Pro Phe Thr Ile
Asp Lys465 47069583PRTinfluenza B virus 69Met Lys Ala Ile Ile Val
Leu Leu Met Val Val Thr Ser Asn Ala Asp1 5 10 15Arg Ile Cys Thr Gly
Ile Thr Ser Ser Asn Ser Pro His Val Val Lys20 25 30Thr Ala Thr Gln
Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr35 40 45Thr Thr Pro
Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr50 55 60Arg Gly
Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val65 70 75
80Ala Leu Gly Arg Pro Met Cys Ile Gly Ile Thr Pro Ser Ala Lys Ala85
90 95Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro
Ile100 105 110Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu
Leu Arg Gly115 120 125Tyr Glu His Ile Arg Leu Ser Thr His Asn Val
Ile Asn Ala Glu Arg130 135 140Ala Pro Gly Gly Pro Tyr Arg Leu Gly
Thr Ser Gly Ser Cys Pro Asn145 150 155 160Val Thr Ser Arg Ser Gly
Phe Phe Ala Thr Met Ala Trp Ala Val Pro165 170 175Arg Asp Asn Lys
Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr180 185 190Ile Cys
Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser195 200
205Asp Asn Lys Ile Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro
Gln210 215 220Lys Phe Thr Ser Ser Ala Asn Gly Ile Thr Thr His Tyr
Val Ser Gln225 230 235 240Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp
Gly Gly Leu Pro Gln Ser245 250 255Gly Arg Ile Val Val Asp Tyr Met
Val Gln Lys Pro Gly Lys Thr Gly260 265 270Thr Ile Val Tyr Gln Arg
Gly Val Leu Leu Pro Gln Lys Val Trp Cys275 280 285Ala Ser Gly Arg
Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly290 295 300Glu Ala
Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys305 310 315
320Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro
Ile325 330 335Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys
Tyr Arg Pro340 345 350Pro Ala Lys Leu Leu Lys Glu Lys Gly Phe Phe
Gly Ala Ile Ala Gly355 360 365Phe Leu Glu Gly Gly Trp Glu Gly Met
Ile Ala Gly Trp His Gly Tyr370 375 380Thr Ser His Gly Ala His Gly
Val Ala Val Ala Ala Asp Leu Lys Ser385 390 395 400Thr Gln Glu Ala
Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser405 410 415Glu Leu
Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu420 425
430Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu
Arg435 440 445Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu
Leu Ser Asn450 455 460Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu
Leu Ala Leu Glu Arg465 470 475 480Lys Leu Lys Lys Met Leu Gly Pro
Ser Ala Val Asp Ile Gly Asn Gly485 490 495Cys Phe Glu Thr Lys His
Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile500 505 510Ala Ala Gly Thr
Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp515 520 525Ser Leu
Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn530 535
540His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala
Val545 550 555 560Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val
Ser Arg Asp Asn565 570 575Val Ser Cys Ser Ile Cys
Leu58070465PRTinfluenza B virus 70Met Leu Pro Ser Thr Ile Gln Thr
Leu Thr Leu Phe Leu Thr Ser Gly1 5 10 15Gly Val Leu Leu Ser Leu Tyr
Val Ser Ala Leu Leu Ser Tyr Leu Leu20 25 30Tyr Ser Asp Ile Leu Leu
Lys Phe Ser Pro Lys Ile Ile Ala Pro Thr35 40 45Thr Ser Leu Asp Cys
Ala Asn Ala Ser Asn Val Gln Ala Val Asn His50 55 60Ser Ala Thr Lys
Glu Met Lys Phe Leu Pro Pro Glu Pro Glu Trp Thr65 70 75 80Tyr Pro
Arg Leu Ser Cys Gln Gly Ser Thr Phe Gln Lys Ala Leu Leu85 90 95Ile
Ser Pro His Arg Phe Gly Glu Ala Lys Gly Asn Ser Ala Pro Leu100 105
110Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys Lys
His115 120 125Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr
Tyr Asn Gly130 135 140Thr Arg Glu Asp Arg Asn Lys Leu Arg His Leu
Ile Ser Val Asn Leu145 150 155 160Gly Lys Ile Pro Thr Val Glu Asn
Ser Ile Phe His Met Ala Ala Trp165 170 175Ser Gly Ser Ala Cys His
Asp Gly Arg Glu Trp Thr Tyr Ile Gly Val180 185 190Asp Gly Pro Asp
Ser Asn Ala Leu Ile Lys Ile Lys Tyr Gly Glu Ala195 200 205Tyr Thr
Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg Thr Gln210 215
220Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met Ile
Thr225 230 235 240Asp Gly Ser Ala Ser Gly Ile Ser Lys Cys Arg Phe
Leu Lys Ile Arg245 250 255Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro
Thr Gly Arg Val Glu His260 265 270Thr Glu Glu Cys Thr Cys Gly Phe
Ala Ser Asn Lys Thr Ile Glu Cys275 280 285Ala Cys Arg Asp Asn Ser
Tyr Thr Ala Lys Arg Pro Phe Val Lys Leu290 295 300Asn Val Glu Thr
Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Glu Thr305 310 315 320Tyr
Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly Pro Cys325 330
335Glu Ser Asn Gly Asp Lys Gly Ser Gly Gly Val Lys Gly Gly Phe
Val340 345 350His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser
Arg Thr Met355 360 365Ser Lys Thr Lys Arg Met Gly Met Glu Leu Tyr
Val Lys Tyr Asp Gly370 375 380Asp Pro Trp Thr Asp Ser Asp Ala Leu
Ala Pro Ser Gly Val Met Val385 390 395 400Ser Met Glu Glu Pro Gly
Trp Tyr Ser Phe Gly Phe Glu Ile Lys Asp405 410 415Lys Lys Cys Asp
Val Pro Cys Ile Gly Ile Glu Met Val His Asp Gly420 425 430Gly Lys
Arg Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu Met435 440
445Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asn Met
Ala450 455 460Leu46571584PRTinfluenza B virus 71Met Lys Ala Ile Ile
Val Leu Leu Met Val Val Thr Ser Asn Ala Asp1 5 10 15Arg Ile Cys Thr
Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys20 25 30Thr Ala Thr
Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr35 40 45Thr Thr
Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr50 55 60Arg
Gly Lys Leu Cys Pro Thr Cys Leu Asn Cys Thr Asp Leu Asp Val65 70 75
80Ala Leu Gly Arg Pro Met Cys Val Gly Val Thr Pro Ser Ala Lys Ala85
90 95Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro
Ile100 105 110Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu
Leu Arg Gly115 120 125Tyr Glu Lys Ile Arg Leu Ser Thr Gln Ile Val
Ile Asn Ala Glu Lys130 135 140Ala Pro Gly Gly Pro Tyr Arg Leu Gly
Thr Ser Gly Ser Cys Pro Asn145 150 155 160Ala Thr Ser Arg Ser Gly
Phe Phe Ala Thr Met Ala Trp Ala Val Pro165 170 175Lys Asp Asn Asn
Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro180 185 190His Ile
Cys Thr Lys Glu Glu Asp Gln Ile Thr Val Trp Gly Phe His195 200
205Ser Asp Asp Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn
Pro210 215 220Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His
Tyr Val Ser225 230 235 240Gln Ile Gly Gly Phe Pro Asp Gln Thr Glu
Asp Gly Gly Leu Pro Gln245 250 255Ser Gly Arg Ile Val Val Asp Tyr
Met Val Gln Lys Pro Gly Lys Thr260 265 270Gly Thr Ile Val Tyr Gln
Arg Gly Ile Leu Leu Pro Gln Lys Val Trp275 280 285Cys Ala Ser Gly
Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile290 295 300Gly Glu
Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser305 310 315
320Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys
Pro325 330 335Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr
Lys Tyr Arg340 345 350Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe
Phe Gly Ala Ile Ala355 360 365Gly Phe Leu Glu Gly Gly Trp Glu Gly
Met Ile Ala Gly Trp His Gly370 375 380Tyr Thr Ser His Gly Ala His
Gly Val Ala Val Ala Ala Asp Leu Lys385 390 395 400Ser Thr Gln Glu
Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu405 410 415Ser Glu
Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp420 425
430Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp
Leu435 440 445Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val
Leu Leu Ser450 455 460Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His
Leu Leu Ala Leu Glu465 470 475 480Arg Lys Leu Lys Lys Met Leu Gly
Pro Ser Ala Val Asp Ile Gly Asn485 490 495Gly Cys Phe Glu Thr Lys
His Lys Cys Asn Gln Thr Cys Leu Asp Arg500 505 510Ile Ala Ala Gly
Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe515 520 525Asp Ser
Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp530 535
540Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu
Ala545 550 555 560Val Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met
Ile Ser Arg Asp565 570 575Asn Val Ser Cys Ser Ile Cys
Leu58072466PRTinfluenza B virus 72Met Leu Pro Ser Thr Ile Gln Thr
Leu Thr Leu Phe Leu Thr Ser Gly1 5 10 15Gly Val Leu Leu Ser Leu Tyr
Val Ser Ala Ser Leu Ser Tyr Leu Leu20 25 30Tyr Ser Asp Ile Leu Leu
Lys Phe Ser Pro Thr Glu Ile Thr Ala Pro35 40 45Thr Met Pro Leu Asn
Cys Ala Asn Ala Ser Asn Val Gln Ala Val Asn50 55 60Arg Ser Ala Thr
Lys Gly Val Thr Leu Pro Leu Pro Glu Pro Glu Trp65 70 75 80Thr Tyr
Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala Leu85 90 95Leu
Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala Pro100 105
110Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys
Arg115 120 125His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly
Tyr Tyr Asn130 135 140Gly Thr Arg Glu Asp Arg Asn Lys Leu Arg His
Leu Ile Ser Val Lys145 150 155 160Leu Gly Lys Ile Pro Thr Val Glu
Asn Ser Ile Phe His Met Ala Ala165 170 175Trp Ser Gly Ser Ala Cys
His Asp Gly Arg Glu Trp Thr Tyr Ile Gly180 185 190Val Asp Gly Pro
Asp Ser Asn Ala Leu Leu Lys Ile Lys Tyr Gly Glu195 200 205Ala Tyr
Thr Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg Thr210 215
220Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met
Ile225 230 235
240Thr Asp Gly Ser Ala Ser Gly Ile Ser Glu Cys Arg Phe Leu Lys
Ile245 250 255Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly
Arg Val Glu260 265 270His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser
Asn Lys Thr Ile Glu275 280 285Cys Ala Cys Arg Asp Asn Ser Tyr Thr
Ala Lys Arg Pro Phe Val Lys290 295 300Leu Asn Val Glu Thr Asp Thr
Ala Glu Ile Arg Leu Met Cys Thr Glu305 310 315 320Thr Tyr Leu Asp
Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly Pro325 330 335Cys Glu
Ser Asn Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly Phe340 345
350Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg
Thr355 360 365Met Ser Lys Thr Lys Arg Met Gly Met Gly Leu Tyr Val
Lys Tyr Asp370 375 380Gly Asp Pro Trp Ile Asp Ser Asp Ala Leu Thr
Leu Ser Gly Val Met385 390 395 400Val Ser Met Glu Glu Pro Gly Trp
Tyr Ser Phe Gly Phe Glu Ile Lys405 410 415Asp Lys Lys Cys Asp Val
Pro Cys Ile Gly Ile Glu Met Val His Asp420 425 430Gly Gly Lys Lys
Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu435 440 445Met Gly
Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp Met450 455
460Ala Leu46573584PRTinfluenza B virus 73Met Lys Ala Ile Ile Val
Leu Leu Met Val Val Thr Ser Asn Ala Asp1 5 10 15Arg Ile Cys Thr Gly
Ile Thr Ser Ser Asn Ser Pro His Val Val Lys20 25 30Thr Ala Thr Gln
Gly Glu Val Asn Val Thr Gly Ala Ile Pro Leu Thr35 40 45Thr Thr Pro
Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr50 55 60Arg Gly
Lys Leu Cys Pro Thr Cys Leu Asn Cys Thr Asp Leu Asp Val65 70 75
80Ala Leu Gly Arg Pro Met Cys Val Gly Ile Thr Pro Ser Ala Lys Ala85
90 95Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro
Ile100 105 110Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu
Leu Arg Gly115 120 125Tyr Glu Lys Ile Arg Leu Ser Thr Gln Asn Val
Ile Asn Ala Glu Lys130 135 140Ala Pro Gly Gly Pro Tyr Arg Leu Gly
Thr Ser Gly Ser Cys Pro Asn145 150 155 160Ala Thr Ser Lys Ser Gly
Phe Phe Ala Thr Met Ala Trp Ala Val Pro165 170 175Arg Asp Asn Asn
Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro180 185 190His Ile
Cys Thr Lys Glu Glu Asp Gln Ile Thr Val Trp Gly Phe His195 200
205Ser Asp Asp Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn
Pro210 215 220Gln Lys Phe Thr Ser Ser Ala Asn Gly Ile Thr Thr His
Tyr Val Ser225 230 235 240Gln Ile Gly Gly Phe Pro Asp Gln Thr Glu
Asp Gly Gly Leu Pro Gln245 250 255Ser Gly Arg Ile Val Val Asp Tyr
Met Val Gln Lys Pro Gly Lys Thr260 265 270Gly Thr Ile Val Tyr Gln
Arg Gly Ile Leu Leu Pro Gln Lys Val Trp275 280 285Cys Ala Ser Gly
Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile290 295 300Gly Glu
Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser305 310 315
320Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys
Pro325 330 335Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr
Lys Tyr Arg340 345 350Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe
Phe Gly Ala Ile Ala355 360 365Gly Phe Leu Glu Gly Gly Trp Glu Gly
Met Ile Ala Gly Trp His Gly370 375 380Tyr Thr Ser His Gly Ala His
Gly Val Ala Val Ala Ala Asp Leu Lys385 390 395 400Ser Thr Gln Glu
Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu405 410 415Ser Glu
Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp420 425
430Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp
Leu435 440 445Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val
Leu Leu Ser450 455 460Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His
Leu Leu Ala Leu Glu465 470 475 480Arg Lys Leu Lys Lys Met Leu Gly
Pro Ser Ala Ile Asp Ile Gly Asn485 490 495Gly Cys Phe Glu Thr Lys
His Lys Cys Asn Gln Thr Cys Leu Asp Arg500 505 510Ile Ala Ala Gly
Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe515 520 525Asp Ser
Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp530 535
540Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu
Ala545 550 555 560Val Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met
Ile Ser Arg Asp565 570 575Asn Val Ser Cys Ser Ile Cys
Leu58074466PRTinfluenza B virus 74Met Leu Pro Ser Thr Ile Gln Thr
Leu Thr Leu Phe Leu Thr Ser Gly1 5 10 15Gly Val Leu Leu Ser Leu Tyr
Val Ser Ala Ser Leu Ser Tyr Leu Leu20 25 30Tyr Ser Asp Ile Leu Leu
Lys Phe Ser Pro Thr Glu Ile Thr Ala Pro35 40 45Ala Met Pro Leu Asp
Cys Ala Asn Ala Ser Asn Val Gln Ala Val Asn50 55 60Arg Ser Ala Thr
Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu Trp65 70 75 80Thr Tyr
Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala Leu85 90 95Leu
Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala Pro100 105
110Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys
Lys115 120 125His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly
Tyr Tyr Asn130 135 140Gly Thr Arg Glu Asp Arg Asn Lys Leu Arg His
Leu Ile Ser Val Lys145 150 155 160Phe Gly Lys Ile Pro Thr Val Glu
Asn Ser Ile Phe His Met Ala Ala165 170 175Trp Ser Gly Ser Ala Cys
His Asp Gly Lys Glu Trp Thr Tyr Ile Gly180 185 190Val Asp Gly Pro
Asp Ser Asn Ala Leu Leu Lys Ile Lys Tyr Gly Glu195 200 205Ala Tyr
Thr Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg Thr210 215
220Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asn Cys Tyr Leu Met
Ile225 230 235 240Thr Asp Gly Ser Ala Ser Gly Ile Ser Glu Cys Arg
Phe Leu Lys Ile245 250 255Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe
Pro Thr Gly Arg Val Lys260 265 270His Thr Glu Glu Cys Thr Cys Gly
Phe Ala Ser Asn Lys Thr Ile Glu275 280 285Cys Ala Cys Arg Asp Asn
Ser Tyr Thr Ala Lys Arg Pro Phe Val Lys290 295 300Leu Asn Val Glu
Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Glu305 310 315 320Thr
Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly Pro325 330
335Cys Glu Ser Asn Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly
Phe340 345 350Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr
Ser Arg Thr355 360 365Met Ser Lys Thr Lys Arg Met Gly Met Gly Leu
Tyr Val Lys Tyr Asp370 375 380Gly Asp Pro Trp Thr Asp Ser Asp Ala
Leu Ala Leu Ser Gly Val Met385 390 395 400Val Ser Met Glu Glu Pro
Gly Trp Tyr Ser Phe Gly Phe Glu Ile Lys405 410 415Asp Lys Lys Cys
Asp Val Pro Cys Ile Gly Ile Glu Met Val His Asp420 425 430Gly Gly
Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu435 440
445Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp
Met450 455 460Ala Leu46575583PRTinfluenza B virus 75Met Lys Ala Ile
Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp1 5 10 15Arg Ile Cys
Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys20 25 30Thr Ala
Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr35 40 45Thr
Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr50 55
60Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val65
70 75 80Ala Leu Gly Arg Pro Met Cys Ile Gly Ile Thr Pro Ser Ala Lys
Ala85 90 95Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe
Pro Ile100 105 110Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn
Leu Leu Arg Gly115 120 125Tyr Glu His Ile Arg Leu Ser Thr His Asn
Val Ile Asn Ala Glu Arg130 135 140Ala Pro Gly Gly Pro Tyr Arg Leu
Gly Thr Ser Gly Ser Cys Pro Asn145 150 155 160Val Thr Ser Arg Ser
Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro165 170 175Arg Asp Asn
Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr180 185 190Ile
Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser195 200
205Asp Asn Lys Ile Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro
Gln210 215 220Lys Phe Thr Ser Ser Ala Asn Gly Ile Thr Thr His Tyr
Val Ser Gln225 230 235 240Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp
Gly Gly Leu Pro Gln Ser245 250 255Gly Arg Ile Val Val Asp Tyr Met
Val Gln Lys Pro Gly Lys Thr Gly260 265 270Thr Ile Val Tyr Gln Arg
Gly Val Leu Leu Pro Gln Lys Val Trp Cys275 280 285Ala Ser Gly Arg
Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly290 295 300Glu Ala
Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys305 310 315
320Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro
Ile325 330 335Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys
Tyr Arg Pro340 345 350Pro Ala Lys Leu Leu Lys Glu Lys Gly Phe Phe
Gly Ala Ile Ala Gly355 360 365Phe Leu Glu Gly Gly Trp Glu Gly Met
Ile Ala Gly Trp His Gly Tyr370 375 380Thr Ser His Gly Ala His Gly
Val Ala Val Ala Ala Asp Leu Lys Ser385 390 395 400Thr Gln Glu Ala
Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser405 410 415Glu Leu
Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu420 425
430Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu
Arg435 440 445Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu
Leu Ser Asn450 455 460Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu
Leu Ala Leu Glu Arg465 470 475 480Lys Leu Lys Lys Met Leu Gly Pro
Ser Ala Val Asp Ile Gly Asn Gly485 490 495Cys Phe Glu Thr Lys His
Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile500 505 510Ala Ala Gly Thr
Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp515 520 525Ser Leu
Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn530 535
540His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala
Val545 550 555 560Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val
Ser Arg Asp Asn565 570 575Val Ser Cys Ser Ile Cys
Leu58076465PRTinfluenza B virus 76Met Leu Pro Ser Thr Ile Gln Thr
Leu Thr Leu Phe Leu Thr Ser Gly1 5 10 15Gly Val Leu Leu Ser Leu Tyr
Val Ser Ala Leu Leu Ser Tyr Leu Leu20 25 30Tyr Ser Asp Ile Leu Leu
Lys Phe Ser Pro Lys Ile Ile Ala Pro Thr35 40 45Thr Ser Leu Asp Cys
Ala Asn Ala Ser Asn Val Gln Ala Val Asn His50 55 60Ser Ala Thr Lys
Glu Met Lys Phe Leu Pro Pro Glu Pro Glu Trp Thr65 70 75 80Tyr Pro
Arg Leu Ser Cys Gln Gly Ser Thr Phe Gln Lys Ala Leu Leu85 90 95Ile
Ser Pro His Arg Phe Gly Glu Ala Lys Gly Asn Ser Ala Pro Leu100 105
110Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys Lys
His115 120 125Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr
Tyr Asn Gly130 135 140Thr Arg Glu Asp Arg Asn Lys Leu Arg His Leu
Ile Ser Val Asn Leu145 150 155 160Gly Lys Ile Pro Thr Val Glu Asn
Ser Ile Phe His Met Ala Ala Trp165 170 175Ser Gly Ser Ala Cys His
Asp Gly Arg Glu Trp Thr Tyr Ile Gly Val180 185 190Asp Gly Pro Asp
Ser Asn Ala Leu Ile Lys Ile Lys Tyr Gly Glu Ala195 200 205Tyr Thr
Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg Thr Gln210 215
220Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met Ile
Thr225 230 235 240Asp Gly Ser Ala Ser Gly Ile Ser Lys Cys Arg Phe
Leu Lys Ile Arg245 250 255Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro
Thr Gly Arg Val Glu His260 265 270Thr Glu Glu Cys Thr Cys Gly Phe
Ala Ser Asn Lys Thr Ile Glu Cys275 280 285Ala Cys Arg Asp Asn Ser
Tyr Thr Ala Lys Arg Pro Phe Val Lys Leu290 295 300Asn Val Glu Thr
Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Glu Thr305 310 315 320Tyr
Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly Pro Cys325 330
335Glu Ser Asn Gly Asp Lys Gly Ser Gly Gly Val Lys Gly Gly Phe
Val340 345 350His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser
Arg Thr Met355 360 365Ser Lys Thr Lys Arg Met Gly Met Glu Leu Tyr
Val Lys Tyr Asp Gly370 375 380Asp Pro Trp Thr Asp Ser Asp Ala Leu
Ala Pro Ser Gly Val Met Val385 390 395 400Ser Met Glu Glu Pro Gly
Trp Tyr Ser Phe Gly Phe Glu Ile Lys Asp405 410 415Lys Lys Cys Asp
Val Pro Cys Ile Gly Ile Glu Met Val His Asp Gly420 425 430Gly Lys
Arg Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu Met435 440
445Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asn Met
Ala450 455 460Leu46577585PRTinfluenza B virus 77Met Lys Ala Ile Ile
Val Leu Leu Met Val Val Thr Ser Asn Ala Asp1 5 10 15Arg Ile Cys Thr
Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys20 25 30Thr Ala Thr
Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr35 40 45Thr Thr
Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr50 55 60Arg
Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val65 70 75
80Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Lys Val85
90 95Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro
Ile100 105 110Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu
Leu Arg Gly115 120 125Tyr Glu Arg Ile Arg Leu Ser Asn His Asn Val
Ile Asn Ala Glu Lys130 135 140Ala Pro Gly Gly Pro Tyr Lys Ile Gly
Thr Ser Gly Ser Cys Pro Asn145 150 155 160Val Thr Asn Gly Asn Gly
Phe Phe Ala Thr Met Ala Trp Ala Val Pro165 170 175Lys Asn Glu Asn
Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu Val180 185 190Pro Tyr
Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe195 200
205His Ser Asp Ser Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser
Lys210 215 220Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr
His Tyr Val225 230 235 240Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr
Glu Asp Gly Gly Leu Pro245 250 255Gln Ser Gly Arg Ile Val Val Asp
Tyr Met Val Gln Lys Ser Gly Lys260 265 270Thr Gly Thr Ile Thr Tyr
Gln Arg Gly Ile Leu Leu Pro Gln Lys Val275 280 285Trp Cys Ala Ser
Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu290 295 300Ile Gly
Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys305 310 315
320Ser Lys Pro Tyr
Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys325 330 335Pro Ile
Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr340 345
350Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala
Ile355 360 365Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala
Gly Trp His370 375 380Gly Tyr Thr Ser His Gly Ala His Gly Val Ala
Val Ala Ala Asp Leu385 390 395 400Lys Ser Thr Gln Glu Ala Ile Asn
Lys Ile Thr Lys Asn Leu Asn Ser405 410 415Leu Ser Glu Leu Glu Val
Lys Asn Leu Gln Arg Leu Ser Gly Ala Met420 425 430Asp Glu Leu His
Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp435 440 445Leu Arg
Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu450 455
460Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala
Leu465 470 475 480Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala
Val Glu Ile Gly485 490 495Asn Gly Cys Phe Glu Thr Lys His Lys Cys
Asn Gln Thr Cys Leu Asp500 505 510Arg Ile Ala Ala Gly Thr Phe Asn
Ala Gly Glu Phe Ser Leu Pro Thr515 520 525Phe Asp Ser Leu Asn Ile
Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu530 535 540Asp Asn His Thr
Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu545 550 555 560Ala
Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg565 570
575Asp Asn Val Ser Cys Ser Ile Cys Leu580 58578466PRTinfluenza B
virus 78Met Leu Pro Ser Thr Ile Gln Thr Leu Thr Leu Phe Leu Thr Ser
Gly1 5 10 15Gly Val Leu Leu Ser Leu Tyr Val Ser Ala Leu Leu Ser Tyr
Leu Leu20 25 30Tyr Ser Asp Ile Leu Leu Lys Phe Ser Pro Thr Lys Ile
Ile Ala Pro35 40 45Thr Thr Ser Leu Asp Ser Ala Asn Ala Ser Asn Phe
Gln Ala Val Asn50 55 60His Ser Ala Thr Lys Glu Met Thr Phe Leu Leu
Pro Glu Pro Glu Trp65 70 75 80Thr Tyr Pro Arg Leu Ser Cys Gln Gly
Ser Thr Phe Gln Lys Ala Leu85 90 95Leu Ile Ser Pro His Arg Phe Gly
Glu Ala Lys Gly Asn Ser Ala Pro100 105 110Leu Ile Ile Arg Glu Pro
Phe Ile Ala Cys Gly Pro Lys Glu Cys Lys115 120 125His Phe Ala Leu
Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn130 135 140Gly Thr
Arg Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val Asn145 150 155
160Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala
Ala165 170 175Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr
Tyr Ile Gly180 185 190Val Asp Gly Pro Asp Ser Asn Ala Leu Ile Lys
Ile Lys Tyr Gly Glu195 200 205Ala Tyr Thr Asp Thr Tyr His Ser Tyr
Ala Asn Asn Ile Leu Arg Thr210 215 220Gln Glu Ser Ala Cys Asn Cys
Ile Gly Gly Asp Cys Tyr Leu Met Ile225 230 235 240Thr Asp Gly Ser
Ala Ser Gly Ile Ser Lys Cys Arg Phe Leu Lys Ile245 250 255Arg Glu
Gly Arg Ile Val Lys Glu Ile Phe Pro Thr Gly Arg Val Glu260 265
270His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile
Glu275 280 285Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro
Phe Val Lys290 295 300Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg
Leu Met Cys Thr Glu305 310 315 320Thr Tyr Leu Asp Thr Pro Arg Pro
Asp Asp Gly Ser Ile Thr Gly Pro325 330 335Cys Glu Ser Asn Gly Asp
Lys Gly Ser Gly Gly Ile Lys Gly Gly Phe340 345 350Val His Gln Arg
Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr355 360 365Met Ser
Lys Thr Lys Arg Met Gly Met Glu Leu Tyr Val Lys Tyr Asp370 375
380Gly Asp Pro Trp Thr Asp Ser Asp Ala Leu Ala Pro Ser Gly Val
Met385 390 395 400Val Ser Ile Glu Glu Pro Gly Trp Tyr Ser Phe Gly
Phe Glu Ile Lys405 410 415Asp Lys Lys Cys Asp Val Pro Cys Ile Gly
Ile Glu Met Val His Asp420 425 430Gly Gly Lys Thr Thr Trp His Ser
Ala Ala Thr Ala Ile Tyr Cys Leu435 440 445Met Gly Ser Gly Gln Leu
Leu Trp Asp Thr Ile Thr Gly Val Asp Met450 455 460Ala
Leu46579585PRTinfluenza B virus 79Met Lys Ala Ile Ile Val Leu Leu
Met Val Val Thr Ser Asn Ala Asp1 5 10 15Arg Ile Cys Thr Gly Ile Thr
Ser Ser Asn Ser Pro His Val Val Lys20 25 30Thr Ala Thr Gln Gly Glu
Val Asn Val Thr Gly Val Ile Pro Leu Thr35 40 45Thr Thr Pro Thr Lys
Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr50 55 60Arg Gly Lys Leu
Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val65 70 75 80Ala Leu
Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Lys Val85 90 95Ser
Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile100 105
110Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg
Gly115 120 125Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn
Ala Glu Lys130 135 140Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser
Gly Ser Cys Pro Asn145 150 155 160Val Thr Asn Gly Asn Gly Phe Phe
Ala Thr Met Ala Trp Ala Val Pro165 170 175Lys Asn Asp Asn Asn Lys
Thr Ala Thr Asn Ser Leu Thr Ile Glu Val180 185 190Pro Tyr Ile Cys
Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe195 200 205His Ser
Asp Asn Glu Ala Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys210 215
220Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr
Val225 230 235 240Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp
Gly Gly Leu Pro245 250 255Gln Ser Gly Arg Ile Val Val Asp Tyr Met
Val Gln Lys Ser Gly Lys260 265 270Thr Gly Thr Ile Thr Tyr Gln Arg
Gly Ile Leu Leu Pro Gln Lys Val275 280 285Trp Cys Ala Ser Gly Arg
Ser Lys Val Ile Lys Gly Ser Leu Pro Leu290 295 300Ile Gly Glu Ala
Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys305 310 315 320Ser
Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys325 330
335Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys
Tyr340 345 350Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe
Gly Ala Ile355 360 365Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met
Ile Ala Gly Trp His370 375 380Gly Tyr Thr Ser His Gly Ala His Gly
Val Ala Val Ala Ala Asp Leu385 390 395 400Lys Ser Thr Gln Glu Ala
Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser405 410 415Leu Ser Glu Leu
Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met420 425 430Asp Glu
Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp435 440
445Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu
Leu450 455 460Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu
Leu Ala Leu465 470 475 480Glu Arg Lys Leu Lys Lys Met Leu Gly Pro
Ser Ala Val Glu Ile Gly485 490 495Asn Gly Cys Phe Glu Thr Lys His
Lys Cys Asn Gln Thr Cys Leu Asp500 505 510Arg Ile Ala Ala Gly Thr
Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr515 520 525Phe Asp Ser Leu
Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu530 535 540Asp Asn
His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu545 550 555
560Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser
Arg565 570 575Asp Asn Val Ser Cys Ser Ile Cys Leu580
58580466PRTinfluenza B virus 80Met Leu Pro Ser Thr Ile Gln Thr Leu
Thr Leu Phe Leu Thr Ser Gly1 5 10 15Gly Val Leu Leu Ser Leu Tyr Val
Ser Ala Ser Leu Ser Tyr Leu Leu20 25 30Tyr Ser Asp Ile Leu Leu Lys
Phe Ser Pro Thr Glu Ile Thr Ala Pro35 40 45Thr Met Pro Leu Asp Cys
Ala Asn Ala Ser Asn Val Gln Ala Val Asn50 55 60Arg Ser Ala Thr Lys
Gly Val Thr Leu Leu Leu Pro Glu Pro Glu Trp65 70 75 80Thr Tyr Pro
Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala Leu85 90 95Leu Ile
Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala Pro100 105
110Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys
Lys115 120 125His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly
Tyr Tyr Asn130 135 140Gly Thr Arg Gly Asp Arg Asn Lys Leu Arg His
Leu Ile Ser Val Lys145 150 155 160Leu Gly Lys Ile Pro Thr Val Glu
Asn Ser Ile Phe His Met Ala Ala165 170 175Trp Ser Gly Ser Ala Cys
His Asp Gly Lys Glu Trp Thr Tyr Ile Gly180 185 190Val Asp Gly Pro
Asp Asn Asn Ala Leu Leu Lys Ile Lys Tyr Gly Glu195 200 205Ala Tyr
Thr Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg Thr210 215
220Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asn Cys Tyr Leu Met
Ile225 230 235 240Thr Asp Gly Ser Ala Ser Gly Ile Ser Glu Cys Arg
Phe Leu Lys Ile245 250 255Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe
Pro Thr Gly Arg Val Lys260 265 270His Thr Glu Glu Cys Thr Cys Gly
Phe Ala Ser Asn Lys Thr Ile Glu275 280 285Cys Ala Cys Arg Asp Asn
Ser Tyr Thr Ala Lys Arg Pro Phe Val Lys290 295 300Leu Asn Val Glu
Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Glu305 310 315 320Thr
Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly Pro325 330
335Cys Glu Ser Asn Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly
Phe340 345 350Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr
Ser Arg Thr355 360 365Met Ser Lys Thr Lys Arg Met Gly Met Gly Leu
Tyr Val Lys Tyr Asp370 375 380Gly Asp Pro Trp Ala Asp Ser Asp Ala
Leu Ala Leu Ser Gly Val Met385 390 395 400Val Ser Met Glu Glu Pro
Gly Trp Tyr Ser Phe Gly Phe Glu Ile Lys405 410 415Asp Lys Lys Cys
Asp Val Pro Cys Ile Gly Ile Glu Met Val His Asp420 425 430Gly Gly
Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu435 440
445Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp
Met450 455 460Ala Leu46581584PRTinfluenza B virus 81Met Lys Ala Ile
Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp1 5 10 15Arg Ile Cys
Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys20 25 30Thr Ala
Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr35 40 45Thr
Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr50 55
60Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val65
70 75 80Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys
Ala85 90 95Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe
Pro Ile100 105 110Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn
Leu Leu Arg Gly115 120 125Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn
Val Ile Asp Ala Glu Asn130 135 140Ala Pro Gly Gly Pro Tyr Arg Leu
Gly Thr Ser Gly Ser Cys Pro Asn145 150 155 160Ala Thr Ser Lys Ser
Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro165 170 175Lys Asp Asn
Asn Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro180 185 190Tyr
Val Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His195 200
205Ser Asp Asn Lys Thr Pro Met Lys Asn Leu Tyr Gly Asp Ser Asn
Pro210 215 220Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His
Tyr Val Ser225 230 235 240Gln Ile Gly Gly Phe Pro Ala Gln Thr Glu
Asp Glu Gly Leu Pro Gln245 250 255Ser Gly Arg Ile Val Val Asp Tyr
Met Val Gln Lys Pro Arg Lys Thr260 265 270Gly Thr Ile Val Tyr Gln
Arg Gly Val Leu Leu Pro Gln Lys Val Trp275 280 285Cys Ala Ser Gly
Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile290 295 300Gly Glu
Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser305 310 315
320Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys
Pro325 330 335Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr
Lys Tyr Arg340 345 350Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe
Phe Gly Ala Ile Ala355 360 365Gly Phe Leu Glu Gly Gly Trp Glu Gly
Met Ile Ala Gly Trp His Gly370 375 380Tyr Thr Ser His Gly Ala His
Gly Val Ala Val Ala Ala Asp Leu Lys385 390 395 400Ser Thr Gln Glu
Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu405 410 415Ser Glu
Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp420 425
430Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp
Leu435 440 445Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val
Leu Leu Ser450 455 460Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His
Leu Leu Ala Leu Glu465 470 475 480Arg Lys Leu Lys Lys Met Leu Gly
Pro Ser Ala Val Asp Ile Gly Asn485 490 495Gly Cys Phe Glu Thr Lys
His Lys Cys Asn Gln Thr Cys Leu Asp Arg500 505 510Ile Ala Ala Gly
Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe515 520 525Asp Ser
Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp530 535
540Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu
Ala545 550 555 560Val Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met
Val Ser Arg Asp565 570 575Asn Val Ser Cys Ser Ile Cys
Leu58082466PRTinfluenza B virus 82Met Leu Pro Ser Thr Ile Gln Thr
Leu Thr Leu Phe Leu Thr Ser Gly1 5 10 15Gly Val Leu Leu Ser Leu Tyr
Val Ser Ala Ser Leu Ser Tyr Leu Leu20 25 30Tyr Ser Asp Ile Leu Leu
Lys Phe Ser Thr Thr Glu Ile Thr Ala Pro35 40 45Thr Met Pro Leu Asp
Cys Ala Asn Ala Ser Asn Val Gln Ala Val Asn50 55 60Arg Ser Ala Thr
Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu Trp65 70 75 80Thr Tyr
Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala Leu85 90 95Leu
Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala Pro100 105
110Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys
Lys115 120 125His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly
Tyr Tyr Asn130 135 140Gly Thr Lys Glu Asp Arg Asn Lys Leu Arg His
Leu Ile Ser Val Lys145 150 155 160Leu Gly Lys Ile Pro Thr Val Glu
Asn Ser Ile Phe His Met Ala Ala165 170 175Trp Ser Gly Ser Ala Cys
His Asp Gly Lys Glu Trp Thr Tyr Ile Gly180 185 190Val Asp Gly Pro
Asp Ser Asn Ala Leu Leu Lys Ile Lys Tyr Gly Glu195 200 205Ala Tyr
Thr Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg Thr210 215
220Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asn Cys Tyr Leu Met
Ile225 230 235 240Thr Asp Gly Ser Ala Ser Gly Ile Ser Glu Cys Arg
Phe Leu Lys Ile245 250 255Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe
Pro Thr Gly Arg Val Lys260 265 270His Thr Glu Glu Cys Thr Cys Gly
Phe Ala Ser Asn Lys Thr Ile Glu275
280 285Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val
Lys290 295 300Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met
Cys Thr Glu305 310 315 320Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp
Gly Ser Ile Thr Gly Pro325 330 335Cys Glu Ser Asn Gly Asn Lys Gly
Ser Gly Gly Ile Lys Gly Gly Phe340 345 350Val His Gln Arg Met Ala
Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr355 360 365Met Ser Lys Thr
Lys Arg Met Gly Met Gly Leu Tyr Val Lys Tyr Asp370 375 380Gly Asp
Pro Trp Thr Asp Ser Asp Ala Leu Ala Leu Ser Gly Val Met385 390 395
400Val Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile
Lys405 410 415Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met
Val His Asp420 425 430Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr
Ala Ile Tyr Cys Leu435 440 445Met Gly Ser Gly Gln Leu Leu Trp Asp
Thr Val Thr Gly Val Asp Met450 455 460Ala Leu46583566PRTinfluenza A
virus 83Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe
Ala1 5 10 15Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys
Leu Gly20 25 30His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile
Thr Asn Asp35 40 45Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln
Ser Ser Ser Thr50 55 60Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu
Asp Gly Glu Asn Cys65 70 75 80Thr Leu Ile Asp Ala Leu Leu Gly Asp
Pro Gln Cys Asp Gly Phe Gln85 90 95Asn Lys Lys Trp Asp Leu Phe Val
Glu Arg Ser Lys Ala Tyr Ser Asn100 105 110Cys Tyr Pro Tyr Asp Val
Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val115 120 125Ala Ser Ser Gly
Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr130 135 140Gly Val
Thr Gln Asn Gly Thr Ser Ser Ser Cys Lys Arg Arg Ser Asn145 150 155
160Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe
Lys165 170 175Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys
Phe Asp Lys180 185 190Leu Tyr Ile Trp Gly Val His His Pro Gly Thr
Asn Asn Asp Gln Ile195 200 205Ser Leu Tyr Thr Gln Ala Ser Gly Arg
Ile Thr Val Ser Thr Lys Arg210 215 220Ser Gln Gln Thr Val Ile Pro
Asn Ile Gly Ser Arg Pro Arg Val Arg225 230 235 240Asp Ile Pro Ser
Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly245 250 255Asp Ile
Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly260 265
270Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp
Ala275 280 285Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn
Gly Ser Ile290 295 300Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg
Ile Thr Tyr Gly Ala305 310 315 320Cys Pro Arg Tyr Val Lys Gln Asn
Thr Leu Lys Leu Ala Thr Gly Met325 330 335Arg Asn Val Pro Glu Lys
Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala340 345 350Gly Phe Ile Glu
Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly355 360 365Phe Arg
His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys370 375
380Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg
Leu385 390 395 400Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu
Lys Glu Phe Ser405 410 415Glu Val Glu Gly Arg Ile Gln Asp Leu Glu
Lys Tyr Val Glu Asp Thr420 425 430Lys Ile Asp Leu Trp Ser Tyr Asn
Ala Glu Leu Leu Val Ala Leu Glu435 440 445Asn Gln His Thr Ile Asp
Leu Thr Asp Ser Glu Met Asn Lys Leu Phe450 455 460Glu Arg Thr Lys
Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn465 470 475 480Gly
Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser485 490
495Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala
Leu500 505 510Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser
Gly Tyr Lys515 520 525Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser
Cys Phe Leu Leu Cys530 535 540Val Ala Leu Leu Gly Phe Ile Met Trp
Ala Cys Gln Lys Gly Asn Ile545 550 555 560Arg Cys Asn Ile Cys
Ile56584469PRTinfluenza A virus 84Met Asn Pro Asn Gln Lys Ile Ile
Thr Ile Gly Ser Val Ser Leu Thr1 5 10 15Ile Ser Thr Ile Cys Phe Phe
Met Gln Ile Ala Ile Leu Ile Thr Thr20 25 30Val Thr Leu His Phe Lys
Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn35 40 45Gln Val Met Leu Cys
Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu50 55 60Ile Val Tyr Leu
Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys65 70 75 80Leu Ala
Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asp Ile Thr Gly85 90 95Phe
Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly100 105
110Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp
Lys115 120 125Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn
Asn Val His130 135 140Ser Asn Asp Thr Val His Asp Arg Thr Pro Tyr
Arg Thr Leu Leu Met145 150 155 160Asn Glu Leu Gly Val Pro Phe His
Leu Gly Thr Lys Gln Val Cys Ile165 170 175Ala Trp Ser Ser Ser Ser
Cys His Asp Gly Lys Ala Trp Leu His Val180 185 190Cys Val Thr Gly
Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn195 200 205Gly Arg
Leu Val Asp Ser Ile Val Ser Trp Ser Lys Glu Ile Leu Arg210 215
220Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val
Val225 230 235 240Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr
Lys Ile Leu Phe245 250 255Ile Glu Glu Gly Lys Ile Val His Thr Ser
Thr Leu Ser Gly Ser Ala260 265 270Gln His Val Glu Glu Cys Ser Cys
Tyr Pro Arg Tyr Pro Gly Val Arg275 280 285Cys Val Cys Arg Asp Asn
Trp Lys Gly Ser Asn Arg Pro Ile Val Asp290 295 300Ile Asn Ile Lys
Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly305 310 315 320Leu
Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His325 330
335Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly
Trp340 345 350Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr
Ile Ser Glu355 360 365Lys Leu Arg Ser Gly Tyr Glu Thr Phe Lys Val
Ile Glu Gly Trp Ser370 375 380Asn Pro Asn Ser Lys Leu Gln Ile Asn
Arg Gln Val Ile Val Asp Arg385 390 395 400Gly Asn Arg Ser Gly Tyr
Ser Gly Ile Phe Ser Val Glu Gly Lys Ser405 410 415Cys Ile Asn Arg
Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu420 425 430Glu Thr
Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly435 440
445Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp
Ile450 455 460Asn Leu Met Pro Ile46585550PRTinfluenza A virus 85Gln
Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly1 5 10
15His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp20
25 30Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser
Thr35 40 45Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu
Asn Cys50 55 60Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp
Gly Phe Gln65 70 75 80Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser
Lys Ala Tyr Ser Asn85 90 95Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
Ser Leu Arg Ser Leu Val100 105 110Ala Ser Ser Gly Thr Leu Glu Phe
Asn Asn Glu Ser Phe Asn Trp Thr115 120 125Gly Val Thr Gln Asn Gly
Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn130 135 140Lys Ser Phe Phe
Ser Arg Leu Asn Trp Leu Thr His Leu Lys Tyr Lys145 150 155 160Tyr
Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys165 170
175Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Ser Asp Gln
Ile180 185 190Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser
Thr Lys Arg195 200 205Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser
Arg Pro Arg Val Arg210 215 220Asp Val Ser Ser Arg Ile Ser Ile Tyr
Trp Thr Ile Val Lys Pro Gly225 230 235 240Asp Ile Leu Leu Ile Asn
Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly245 250 255Tyr Phe Lys Ile
Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala260 265 270Pro Ile
Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile275 280
285Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly
Ala290 295 300Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala
Thr Gly Met305 310 315 320Arg Asn Val Pro Glu Lys Gln Thr Arg Gly
Ile Phe Gly Ala Ile Ala325 330 335Gly Phe Ile Glu Asn Gly Trp Glu
Gly Met Val Asp Gly Trp Tyr Gly340 345 350Phe Arg His Gln Asn Ser
Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys355 360 365Ser Thr Gln Ala
Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu370 375 380Ile Gly
Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser385 390 395
400Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp
Thr405 410 415Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val
Ala Leu Glu420 425 430Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu
Met Asn Lys Leu Phe435 440 445Glu Arg Thr Lys Lys Gln Leu Arg Glu
Asn Ala Glu Asp Met Gly Asn450 455 460Gly Cys Phe Lys Ile Tyr His
Lys Cys Asp Asn Ala Cys Ile Glu Ser465 470 475 480Ile Arg Asn Gly
Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu485 490 495Asn Asn
Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys500 505
510Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu
Cys515 520 525Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys
Gly Asn Ile530 535 540Arg Cys Asn Ile Cys Ile545
55086469PRTinfluenza A virus 86Met Asn Pro Asn Gln Lys Ile Ile Thr
Ile Gly Ser Val Ser Leu Thr1 5 10 15Ile Ser Thr Ile Cys Phe Phe Met
Gln Ile Ala Ile Leu Ile Thr Thr20 25 30Val Thr Leu His Phe Lys Gln
Tyr Glu Phe Asn Ser Pro Pro Asn Asn35 40 45Gln Val Met Leu Cys Glu
Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu50 55 60Ile Val Tyr Leu Thr
Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys65 70 75 80Leu Ala Glu
Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asn Ile Thr Gly85 90 95Phe Ala
Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly100 105
110Asp Ile Trp Val Thr Arg Gln Pro Tyr Val Ser Cys Asp Pro Asp
Lys115 120 125Cys Tyr Gln Phe Ala Leu Gly Lys Gly Thr Thr Leu Asn
Asn Val His130 135 140Ser Asn Asp Thr Val His Asp Arg Thr Pro Tyr
Arg Thr Leu Leu Met145 150 155 160Asn Glu Leu Gly Val Pro Phe His
Leu Gly Thr Lys Gln Val Cys Ile165 170 175Ala Trp Ser Ser Ser Ser
Cys His Asp Gly Lys Ala Trp Leu His Val180 185 190Cys Val Thr Gly
Asp Asp Glu Asn Ala Thr Ala Ser Phe Ile Tyr Asn195 200 205Gly Arg
Leu Val Asp Ser Ile Val Ser Trp Ser Lys Lys Ile Leu Arg210 215
220Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val
Val225 230 235 240Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr
Lys Ile Leu Phe245 250 255Ile Glu Glu Gly Lys Ile Val His Thr Ser
Thr Leu Ser Gly Ser Ala260 265 270Gln His Val Glu Glu Cys Ser Cys
Tyr Pro Arg Tyr Pro Gly Val Arg275 280 285Cys Val Cys Arg Asp Asn
Trp Lys Gly Ser Asn Arg Pro Ile Val Asp290 295 300Ile Asn Ile Lys
Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly305 310 315 320Leu
Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His325 330
335Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly Tyr Gly Val Lys Gly
Trp340 345 350Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr
Ile Ser Glu355 360 365Lys Leu Arg Ser Gly Tyr Glu Thr Phe Lys Val
Ile Glu Gly Trp Ser370 375 380Asn Pro Asn Ser Lys Leu Gln Ile Asn
Arg Gln Val Ile Val Asp Arg385 390 395 400Gly Asn Arg Ser Gly Tyr
Ser Gly Ile Phe Ser Val Glu Gly Lys Ser405 410 415Cys Ile Asn Arg
Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln420 425 430Glu Thr
Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly435 440
445Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp
Ile450 455 460Asn Leu Met Pro Ile46587550PRTinfluenza A virus 87Gln
Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly1 5 10
15His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp20
25 30Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser
Thr35 40 45Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu
Asn Cys50 55 60Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp
Gly Phe Gln65 70 75 80Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser
Lys Ala Tyr Ser Asn85 90 95Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
Ser Leu Arg Ser Leu Val100 105 110Ala Ser Ser Gly Thr Leu Glu Phe
Asn Asn Glu Ser Phe Asn Trp Thr115 120 125Gly Val Thr Gln Asn Gly
Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn130 135 140Lys Ser Phe Phe
Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys145 150 155 160Tyr
Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys165 170
175Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Asn Asp Gln
Ile180 185 190Asn Leu Tyr Val Gln Ala Ser Gly Arg Ile Thr Val Ser
Thr Lys Arg195 200 205Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser
Arg Pro Arg Val Arg210 215 220Asp Val Pro Ser Arg Ile Ser Ile Tyr
Trp Thr Ile Val Lys Pro Gly225 230 235 240Asp Ile Leu Leu Ile Ser
Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly245 250 255Tyr Phe Lys Ile
Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala260 265 270Pro Ile
Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile275 280
285Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly
Ala290 295 300Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala
Thr Gly Met305 310 315 320Arg Asn Val Pro Glu Lys Gln Thr Arg Gly
Ile Phe Gly Ala Ile Ala325 330 335Gly Phe Ile Glu Asn Gly Trp Glu
Gly Met Val Asp Gly Trp Tyr Gly340 345 350Phe Arg His Gln Asn Ser
Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys355 360 365Ser Thr Gln Ala
Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu370 375 380Ile Gly
Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser385 390 395
400Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu
Asp Thr405 410 415Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu
Val Ala Leu Glu420 425 430Asn Gln His Thr Ile Asp Leu Thr Asp Ser
Glu Met Asn Lys Leu Phe435 440 445Glu Arg Thr Lys Lys Gln Leu Arg
Glu Asn Ala Glu Asp Met Gly Asn450 455 460Gly Cys Phe Lys Ile Tyr
His Lys Cys Asp Asn Ala Cys Ile Gly Ser465 470 475 480Ile Arg Asn
Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu485 490 495Asn
Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys500 505
510Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu
Cys515 520 525Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys
Gly Asn Ile530 535 540Arg Cys Asn Ile Cys Ile545
55088469PRTinfluenza A virus 88Met Asn Pro Asn Gln Lys Ile Ile Thr
Ile Gly Ser Val Ser Leu Thr1 5 10 15Ile Ser Thr Ile Cys Phe Phe Met
Gln Ile Ala Ile Leu Ile Thr Thr20 25 30Val Thr Leu His Phe Lys Gln
Tyr Glu Phe Asn Ser Pro Pro Asn Asn35 40 45Gln Val Met Leu Cys Glu
Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu50 55 60Ile Val Tyr Leu Thr
Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys65 70 75 80Leu Ala Glu
Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asp Ile Thr Gly85 90 95Phe Ala
Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly100 105
110Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp
Lys115 120 125Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn
Asn Val His130 135 140Ser Asn Asp Thr Val His Asp Arg Thr Pro Tyr
Arg Thr Leu Leu Met145 150 155 160Asn Glu Leu Gly Val Pro Phe His
Leu Gly Thr Lys Gln Val Cys Ile165 170 175Ala Trp Ser Ser Ser Ser
Cys His Asp Gly Lys Ala Trp Leu His Val180 185 190Cys Val Thr Gly
Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn195 200 205Gly Arg
Leu Val Asp Ser Ile Val Ser Trp Ser Lys Lys Ile Leu Arg210 215
220Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val
Val225 230 235 240Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr
Lys Ile Leu Phe245 250 255Ile Glu Glu Gly Lys Ile Val His Thr Ser
Thr Leu Ser Gly Ser Ala260 265 270Gln His Val Glu Glu Cys Ser Cys
Tyr Pro Arg Tyr Pro Gly Val Arg275 280 285Cys Val Cys Arg Asp Asn
Trp Lys Gly Ser Asn Arg Pro Ile Val Asp290 295 300Ile Asn Ile Lys
Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly305 310 315 320Leu
Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His325 330
335Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly
Trp340 345 350Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr
Ile Ser Glu355 360 365Lys Leu Arg Ser Gly Tyr Glu Thr Phe Lys Val
Ile Glu Gly Trp Ser370 375 380Asn Pro Asn Ser Lys Leu Gln Ile Asn
Arg Gln Val Ile Val Asp Arg385 390 395 400Gly Asn Arg Ser Gly Tyr
Ser Gly Ile Phe Ser Val Glu Gly Lys Ser405 410 415Cys Ile Asn Arg
Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu420 425 430Glu Thr
Lys Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly435 440
445Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp
Ile450 455 460Asn Leu Met Pro Ile46589550PRTinfluenza A virus 89Gln
Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly1 5 10
15His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp20
25 30Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser
Thr35 40 45Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu
Asn Cys50 55 60Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp
Gly Phe Gln65 70 75 80Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser
Lys Ala Tyr Ser Asn85 90 95Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
Ser Leu Arg Ser Leu Val100 105 110Ala Ser Ser Gly Thr Leu Glu Phe
Asn Asn Glu Ser Phe Asn Trp Thr115 120 125Gly Val Thr Gln Asn Gly
Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn130 135 140Lys Ser Phe Phe
Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys145 150 155 160Tyr
Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys165 170
175Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Tyr Asp Gln
Ile180 185 190Arg Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser
Thr Lys Arg195 200 205Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser
Arg Pro Arg Val Arg210 215 220Asp Ile Pro Ser Arg Ile Ser Ile Tyr
Trp Thr Ile Val Lys Pro Gly225 230 235 240Asp Ile Leu Leu Ile Asn
Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly245 250 255Tyr Phe Lys Ile
Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala260 265 270Pro Ile
Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile275 280
285Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly
Ala290 295 300Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala
Thr Gly Met305 310 315 320Arg Asn Val Pro Glu Lys Gln Thr Arg Gly
Ile Phe Gly Ala Ile Ala325 330 335Gly Phe Ile Glu Asn Gly Trp Glu
Gly Met Val Asp Gly Trp Tyr Gly340 345 350Phe Arg His Gln Asn Ser
Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys355 360 365Ser Thr Gln Ala
Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu370 375 380Ile Gly
Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser385 390 395
400Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp
Thr405 410 415Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val
Ala Leu Glu420 425 430Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu
Met Asn Lys Leu Phe435 440 445Glu Arg Thr Lys Lys Gln Leu Arg Glu
Asn Ala Glu Asp Met Gly Asn450 455 460Gly Cys Phe Lys Ile Tyr His
Lys Cys Asp Asn Ala Cys Ile Gly Ser465 470 475 480Ile Arg Asn Gly
Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu485 490 495Asn Asn
Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys500 505
510Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu
Cys515 520 525Val Ala Leu Ser Gly Phe Ile Met Trp Ala Cys Gln Lys
Gly Asn Ile530 535 540Arg Cys Asn Ile Cys Ile545
55090469PRTinfluenza A virus 90Met Asn Pro Asn Gln Lys Ile Ile Thr
Ile Gly Ser Val Ser Leu Thr1 5 10 15Ile Ser Thr Ile Cys Phe Phe Met
Gln Ile Ala Ile Leu Ile Thr Thr20 25 30Val Thr Leu His Phe Lys Gln
Tyr Glu Phe Asn Ser Pro Pro Asn Asn35 40 45Gln Val Met Leu Cys Glu
Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu50 55 60Ile Val Tyr Leu Thr
Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys65 70 75 80Leu Ala Glu
Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asp Ile Thr Gly85 90 95Phe Ala
Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly100 105
110Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp
Lys115 120 125Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn
Asn Val His130 135 140Ser Asn Asp Thr Val His Asp Arg Thr Pro Tyr
Arg Thr Leu Leu Met145 150 155 160Asn Glu Leu Gly Val Pro Phe His
Leu Gly Thr Lys Gln Val Cys Ile165 170 175Ala Trp Ser Ser Ser Ser
Cys His Asp Gly Lys Ala Trp Leu His Val180 185 190Cys Val Thr Gly
Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn195 200 205Gly Arg
Leu Val Asp Ser Ile Val Ser Trp Ser Lys Lys Ile Leu Arg210 215
220Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val
Val225 230 235 240Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr
Lys Ile Leu Phe245 250 255Ile Glu Glu Gly Lys Ile Val His Thr Ser
Thr Leu Ser Gly Ser Ala260 265 270Gln His Val Glu Glu Cys Ser Cys
Tyr Pro Arg Tyr Pro Gly Val Arg275 280 285Cys Val Cys Arg Asp Asn
Trp Lys Gly Ser Asn Arg Pro Ile Val Asp290 295 300Ile Asn Ile Lys
Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly305 310 315 320Leu
Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His325 330
335Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly
Trp340 345 350Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr
Ile Ser Glu355 360 365Lys Leu Arg Ser Gly Tyr Glu Thr Phe Lys Val
Ile Glu Gly Trp Ser370 375 380Asn Pro Asn Ser Lys Leu Gln Ile Asn
Arg Gln Val Ile Val Asp Arg385 390 395 400Gly Asn Arg Ser Gly Tyr
Ser Gly Ile Phe Ser Val Glu Gly Lys Ser405 410 415Cys Ile Asn Arg
Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu420 425 430Lys Thr
Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly435 440
445Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp
Ile450 455 460Asn Leu Met Pro Ile46591550PRTinfluenza A virus 91Gln
Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly1 5 10
15His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp20
25 30Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser
Thr35 40 45Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu
Asn Cys50 55 60Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp
Gly Phe Gln65 70 75 80Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser
Lys Ala Tyr Ser Asn85 90 95Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
Ser Leu Arg Ser Leu Val100 105 110Ala Ser Ser Gly Thr Leu Glu Phe
Asn Asn Glu Ser Phe Asn Trp Thr115 120 125Gly Val Thr Gln Asn Gly
Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn130 135 140Lys Ser Phe Phe
Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys145 150 155 160Tyr
Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys165 170
175Leu Tyr Ile Trp Gly Val His His Pro Val Thr Asp Tyr Asp Gln
Ile180 185 190Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser
Thr Lys Arg195 200 205Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser
Arg Pro Arg Val Arg210 215 220Asp Ile Pro Ser Arg Ile Ser Ile Tyr
Trp Thr Ile Val Lys Pro Gly225 230 235 240Asp Ile Leu Leu Ile Asn
Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly245 250 255Tyr Phe Lys Ile
Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala260 265 270Pro Ile
Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile275 280
285Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly
Ala290 295 300Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala
Thr Gly Met305 310 315 320Arg Asn Val Pro Glu Lys Gln Thr Arg Gly
Ile Phe Gly Ala Ile Ala325 330 335Gly Phe Ile Glu Asn Gly Trp Glu
Gly Met Val Asp Gly Trp Tyr Gly340 345 350Phe Arg His Gln Asn Ser
Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys355 360 365Ser Thr Gln Ala
Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu370 375 380Ile Gly
Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser385 390 395
400Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp
Thr405 410 415Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val
Ala Leu Glu420 425 430Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu
Met Asn Lys Leu Phe435 440 445Glu Arg Thr Lys Lys Gln Leu Arg Glu
Asn Ala Glu Asp Met Gly Asn450 455 460Gly Cys Phe Lys Ile Tyr His
Lys Cys Asp Asn Ala Cys Ile Gly Ser465 470 475 480Ile Arg Asn Gly
Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu485 490 495Asn Asn
Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys500 505
510Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu
Cys515 520 525Val Ala Leu Ser Gly Phe Ile Met Trp Ala Cys Gln Lys
Gly Asn Ile530 535 540Arg Cys Asn Ile Cys Ile545
55092469PRTinfluenza A virus 92Met Asn Pro Asn Gln Lys Ile Ile Thr
Ile Gly Ser Val Ser Leu Thr1 5 10 15Ile Ser Thr Ile Cys Phe Phe Met
Gln Ile Ala Ile Leu Ile Thr Thr20 25 30Val Thr Leu His Phe Lys Gln
Tyr Glu Phe Asn Ser Pro Pro Asn Asn35 40 45Gln Val Met Leu Cys Glu
Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu50 55 60Ile Val Tyr Leu Thr
Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys65 70 75 80Leu Ala Glu
Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asp Ile Thr Gly85 90 95Phe Ala
Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly100 105
110Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp
Lys115 120 125Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn
Asn Val His130 135 140Ser Asn Asp Thr Val His Asp Arg Thr Pro Tyr
Arg Thr Leu Leu Met145 150 155 160Asn Glu Leu Gly Val Pro Phe His
Leu Gly Thr Lys Gln Val Cys Ile165 170 175Ala Trp Ser Ser Ser Ser
Cys His Asp Gly Lys Ala Trp Leu His Val180 185 190Cys Val Thr Gly
Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn195 200 205Gly Arg
Leu Val Asp Ser Ile Val Ser Trp Ser Lys Lys Ile Leu Arg210 215
220Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val
Val225 230 235 240Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr
Lys Ile Leu Phe245 250 255Ile Glu Glu Gly Lys Ile Val His Thr Ser
Thr Leu Ser Gly Ser Ala260 265 270Gln His Val Glu Glu Cys Ser Cys
Tyr Pro Arg Tyr Pro Gly Val Arg275 280 285Cys Val Cys Arg Asp Asn
Trp Lys Gly Ser Asn Arg Pro Ile Val Asp290 295 300Ile Asn Ile Lys
Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly305 310 315 320Leu
Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His325 330
335Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly
Trp340 345 350Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr
Ile Ser Glu355 360 365Lys Leu Arg Ser Gly Tyr Glu Thr Phe Lys Val
Ile Glu Gly Trp Ser370 375 380Asn Pro Asn Ser Lys Leu Gln Ile Asn
Arg Gln Val Ile Val Asp Arg385 390 395 400Gly Asn Arg Ser Gly Tyr
Ser Gly Ile Phe Ser Val Glu Gly Lys Ser405 410 415Cys Ile Asn Arg
Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu420 425 430Lys Thr
Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly435 440
445Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp
Ile450 455 460Asn Leu Met Pro
Ile46593569PRTinfluenza B virus 93Asp Arg Ile Cys Thr Gly Ile Thr
Ser Ser Asn Ser Pro His Val Val1 5 10 15Lys Thr Ala Thr Gln Gly Glu
Val Asn Val Thr Gly Val Ile Pro Leu20 25 30Thr Thr Thr Pro Thr Lys
Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg35 40 45Thr Arg Gly Lys Leu
Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp50 55 60Val Ala Leu Gly
Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys65 70 75 80Ala Ser
Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro85 90 95Ile
Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg100 105
110Gly Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala
Glu115 120 125Asn Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Arg
Ser Cys Pro130 135 140Asn Ala Thr Ser Lys Ser Gly Phe Phe Ala Thr
Met Ala Trp Ala Val145 150 155 160Pro Lys Asp Asn Asn Lys Asn Ala
Thr Asn Pro Leu Thr Val Glu Val165 170 175Pro Tyr Val Cys Thr Glu
Gly Glu Asp Gln Ile Thr Val Trp Gly Phe180 185 190His Ser Asp Asn
Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn195 200 205Pro Gln
Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val210 215
220Ser Gln Ile Gly Gly Phe Pro Ala Gln Thr Glu Asp Glu Gly Leu
Pro225 230 235 240Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln
Lys Pro Arg Lys245 250 255Thr Gly Thr Ile Val Tyr Gln Arg Gly Val
Leu Leu Pro Gln Lys Val260 265 270Trp Cys Ala Ser Gly Arg Ser Lys
Val Ile Lys Gly Ser Leu Pro Leu275 280 285Ile Gly Glu Ala Asp Cys
Leu His Glu Lys Tyr Gly Gly Leu Asn Lys290 295 300Ser Lys Pro Tyr
Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys305 310 315 320Pro
Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr325 330
335Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala
Ile340 345 350Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala
Gly Trp His355 360 365Gly Tyr Thr Ser His Gly Ala His Gly Val Ala
Val Ala Ala Asp Leu370 375 380Lys Ser Thr Gln Glu Ala Ile Asn Lys
Ile Thr Lys Asn Leu Asn Ser385 390 395 400Leu Ser Glu Leu Glu Val
Lys Asn Leu Gln Arg Leu Ser Gly Ala Met405 410 415Asp Glu Leu His
Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp420 425 430Leu Arg
Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu435 440
445Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala
Leu450 455 460Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val
Asp Ile Gly465 470 475 480Asn Gly Cys Phe Glu Thr Lys His Lys Cys
Asn Gln Thr Cys Leu Asp485 490 495Arg Ile Ala Ala Gly Thr Phe Asn
Ala Gly Glu Phe Ser Leu Pro Thr500 505 510Phe Asp Ser Leu Asn Ile
Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu515 520 525Asp Asn His Thr
Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu530 535 540Ala Val
Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser Arg545 550 555
560Asp Asn Val Ser Cys Ser Ile Cys Leu56594466PRTinfluenza B virus
94Met Leu Pro Ser Thr Ile Gln Thr Leu Thr Leu Phe Leu Thr Ser Gly1
5 10 15Gly Val Leu Leu Ser Leu Tyr Val Ser Ala Ser Leu Ser Tyr Leu
Leu20 25 30Tyr Ser Asp Ile Leu Leu Lys Phe Ser Thr Thr Glu Thr Thr
Ala Pro35 40 45Thr Met Pro Leu Asp Cys Ala Asn Ala Ser Asn Val Gln
Ala Val Asn50 55 60Arg Ser Ala Thr Lys Gly Val Thr Leu Leu Leu Pro
Glu Pro Glu Trp65 70 75 80Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser
Thr Phe Gln Lys Ala Leu85 90 95Leu Ile Ser Pro His Arg Phe Gly Glu
Thr Lys Gly Asn Ser Ala Pro100 105 110Leu Ile Ile Arg Glu Pro Phe
Ile Ala Cys Gly Pro Lys Glu Cys Lys115 120 125His Phe Ala Leu Thr
His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn130 135 140Gly Thr Arg
Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val Lys145 150 155
160Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala
Ala165 170 175Trp Ser Gly Ser Ala Cys His Asp Gly Lys Glu Trp Thr
Tyr Ile Gly180 185 190Val Asp Gly Pro Asp Ser Asn Ala Leu Leu Lys
Ile Lys Tyr Gly Glu195 200 205Ala Tyr Thr Asp Thr Tyr His Ser Tyr
Ala Asn Asn Ile Leu Arg Thr210 215 220Gln Glu Ser Ala Cys Asn Cys
Ile Gly Gly Asn Cys Tyr Leu Met Ile225 230 235 240Thr Asp Gly Ser
Ala Ser Gly Ile Ser Glu Cys Arg Phe Leu Lys Ile245 250 255Arg Glu
Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val Lys260 265
270His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile
Glu275 280 285Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro
Phe Val Lys290 295 300Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg
Leu Met Cys Thr Glu305 310 315 320Thr Tyr Leu Asp Thr Pro Arg Pro
Asp Asp Gly Ser Ile Thr Gly Pro325 330 335Cys Glu Ser Asn Gly Asn
Lys Gly Ser Gly Gly Ile Lys Gly Gly Phe340 345 350Val His Gln Arg
Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr355 360 365Met Ser
Lys Thr Lys Arg Met Gly Met Gly Leu Tyr Val Lys Tyr Asp370 375
380Gly Asp Pro Trp Thr Asp Ser Asp Ala Leu Ala Leu Ser Gly Val
Met385 390 395 400Val Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly
Phe Glu Ile Lys405 410 415Asp Lys Lys Cys Asp Val Pro Cys Ile Gly
Ile Glu Met Val His Asp420 425 430Gly Gly Lys Glu Thr Trp His Ser
Ala Ala Thr Ala Ile Tyr Cys Leu435 440 445Met Gly Ser Gly Gln Leu
Leu Trp Asp Thr Val Thr Gly Val Asp Met450 455 460Ala
Leu46595569PRTinfluenza B virus 95Asp Arg Ile Cys Thr Gly Ile Thr
Ser Ser Asn Ser Pro His Val Val1 5 10 15Lys Thr Ala Thr Gln Gly Glu
Val Asn Val Thr Gly Val Ile Pro Leu20 25 30Thr Thr Thr Pro Ile Lys
Ser His Phe Ala Asn Leu Lys Gly Thr Arg35 40 45Thr Arg Gly Lys Leu
Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp50 55 60Val Ala Leu Gly
Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys65 70 75 80Ala Ser
Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro85 90 95Ile
Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg100 105
110Gly Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala
Glu115 120 125Lys Ala Leu Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly
Ser Cys Pro130 135 140Asn Ala Thr Ser Lys Ser Gly Phe Phe Ala Thr
Met Ala Trp Ala Val145 150 155 160Pro Lys Asp Asn Asn Lys Asn Ala
Thr Asn Pro Leu Thr Val Glu Val165 170 175Pro Tyr Ile Cys Thr Glu
Gly Glu Asp Gln Ile Thr Val Trp Gly Phe180 185 190His Ser Asp Asp
Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn195 200 205Pro Gln
Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val210 215
220Ser Gln Ile Gly Gly Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu
Pro225 230 235 240Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln
Lys Pro Gly Lys245 250 255Thr Gly Thr Ile Val Tyr Gln Arg Gly Val
Leu Leu Pro Gln Lys Val260 265 270Trp Cys Ala Ser Gly Arg Ser Lys
Val Ile Lys Gly Ser Leu Pro Leu275 280 285Ile Gly Glu Ala Asp Cys
Leu His Glu Lys Tyr Gly Gly Leu Asn Lys290 295 300Ser Lys Pro Tyr
Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys305 310 315 320Pro
Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr325 330
335Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala
Ile340 345 350Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala
Gly Trp His355 360 365Gly Tyr Thr Ser His Gly Ala His Gly Val Ala
Val Ala Ala Asp Leu370 375 380Lys Ser Thr Gln Glu Ala Ile Asn Lys
Ile Thr Lys Asn Leu Asn Ser385 390 395 400Leu Ser Glu Leu Glu Val
Lys Asn Leu Gln Arg Leu Ser Gly Ala Met405 410 415Asp Glu Leu His
Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp420 425 430Leu Arg
Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu435 440
445Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala
Leu450 455 460Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val
Asp Ile Gly465 470 475 480Asn Gly Cys Phe Glu Thr Lys His Lys Cys
Asn Gln Thr Cys Leu Asp485 490 495Arg Ile Ala Ala Gly Thr Phe Asn
Ala Gly Glu Phe Ser Leu Pro Thr500 505 510Phe Asp Ser Leu Asn Ile
Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu515 520 525Asp Asn His Thr
Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu530 535 540Ala Val
Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser Arg545 550 555
560Asp Asn Val Ser Cys Ser Ile Cys Leu56596466PRTinfluenza B virus
96Met Leu Pro Ser Thr Ile Gln Thr Leu Thr Leu Phe Leu Thr Ser Gly1
5 10 15Gly Val Leu Leu Ser Leu Tyr Val Ser Ala Ser Leu Ser Tyr Leu
Leu20 25 30Tyr Ser Asp Ile Leu Leu Lys Phe Ser Thr Thr Glu Ile Thr
Ala Pro35 40 45Thr Met Pro Leu Asp Cys Ala Asn Ala Ser Asn Val Gln
Ala Val Asn50 55 60Arg Ser Ala Thr Lys Gly Val Thr Leu Leu Leu Pro
Glu Pro Glu Trp65 70 75 80Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser
Thr Phe Gln Lys Ala Leu85 90 95Leu Ile Ser Pro His Arg Phe Gly Glu
Thr Lys Gly Asn Ser Ala Pro100 105 110Leu Ile Ile Arg Glu Pro Phe
Ile Ala Cys Gly Pro Lys Glu Cys Lys115 120 125His Phe Ala Leu Thr
His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn130 135 140Gly Thr Arg
Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val Lys145 150 155
160Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala
Ala165 170 175Trp Ser Gly Ser Ala Cys His Asp Gly Lys Glu Trp Thr
Tyr Ile Gly180 185 190Val Asp Gly Pro Asp Ser Asn Ala Leu Leu Lys
Ile Lys Tyr Gly Glu195 200 205Ala Tyr Thr Asp Thr Tyr His Ser Tyr
Ala Asn Asn Ile Leu Arg Thr210 215 220Gln Glu Ser Ala Cys Asn Cys
Ile Gly Gly Asn Cys Tyr Leu Met Ile225 230 235 240Thr Asp Gly Ser
Ala Ser Gly Ile Ser Glu Cys Arg Phe Leu Lys Ile245 250 255Arg Glu
Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val Lys260 265
270His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile
Glu275 280 285Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro
Phe Val Lys290 295 300Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg
Leu Met Cys Thr Glu305 310 315 320Thr Tyr Leu Asp Thr Pro Arg Pro
Asp Asp Gly Ser Ile Thr Gly Pro325 330 335Cys Glu Ser Asn Gly Asn
Lys Gly Ser Gly Gly Ile Lys Gly Gly Phe340 345 350Val His Gln Arg
Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr355 360 365Met Ser
Lys Thr Lys Arg Met Gly Met Gly Leu Tyr Val Lys Tyr Asp370 375
380Gly Asp Pro Trp Ile Asp Ser Asp Ala Leu Ala Leu Ser Gly Val
Met385 390 395 400Val Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly
Phe Glu Ile Lys405 410 415Asp Lys Lys Cys Asp Val Pro Cys Ile Gly
Ile Glu Met Val His Asp420 425 430Gly Gly Lys Glu Thr Trp His Ser
Ala Ala Thr Ala Ile Tyr Cys Leu435 440 445Met Gly Ser Gly Gln Leu
Leu Trp Asp Thr Val Thr Gly Val Asp Met450 455 460Ala Leu465
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