U.S. patent application number 12/262090 was filed with the patent office on 2009-06-18 for modulation of endothelial lipase expression. This patent application is currently assigned to Isis Pharmaceuticals, Inc.. Invention is credited to Kenneth W. Dobie.
Application Number | 20090156538 12/262090 |
Document ID | / |
Family ID | 32506740 |
Filed Date | 2009-06-18 |
United States Patent Application | 20090156538 |
Kind Code | A1 |
Dobie; Kenneth W. | June 18, 2009 |
Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided.
Inventors: | Dobie; Kenneth W.; (Del Mar, CA) |
Correspondence Address: |
JONES DAY for;Isis Pharmaceuticals, Inc. 222 East 41st Street New York NY 10017-6702 US |
Assignee: | Isis Pharmaceuticals, Inc. Carlsbad CA |
Family ID: | 32506740 |
Appl. No.: | 12/262090 |
Filed: | October 30, 2008 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
10319915 | Dec 12, 2002 | 7507808 | ||
12262090 | ||||
Current U.S. Class: | 514/44R |
Current CPC Class: | C12N 15/1137 20130101; C12N 2310/315 20130101; C12N 2310/346 20130101; C12N 2310/3341 20130101; C12N 2310/321 20130101; C07H 21/00 20130101; C12N 2310/11 20130101; C07H 21/04 20130101; C12Y 301/01003 20130101; C12N 2310/341 20130101; C12N 2310/321 20130101; C12N 2310/3525 20130101 |
Class at Publication: | 514/44 |
International Class: | A61K 31/7088 20060101 A61K031/7088; A61K 31/711 20060101 A61K031/711; A61K 31/7105 20060101 A61K031/7105 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 282 <210> SEQ ID NO 1 <211> LENGTH: 20 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 1 tccgtcatcg ctcctcaggg 20 <210> SEQ ID
NO 2 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
2 gtgcgcgcga gcccgaaatc 20 <210> SEQ ID NO 3 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 3 atgcattctg
cccccaagga 20 <210> SEQ ID NO 4 <211> LENGTH: 3927
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (253)...(1755) <400> SEQUENCE: 4 agcagcgagt
ccttgcctcc cggcggctca ggacgagggc agatctcgtt ctggggcaag 60
ccgttgacac tcgctccctg ccaccgcccg ggctccgtgc cgccaagttt tcattttcca
120 ccttctctgc ctccagtccc ccagcccctg gccgagagaa gggtcttacc
ggccgggatt 180 gctggaaaca ccaagaggtg gtttttgttt tttaaaactt
ctgtttcttg ggagggggtg 240 tggcggggca gg atg agc aac tcc gtt cct ctg
ctc tgt ttc tgg agc ctc 291 Met Ser Asn Ser Val Pro Leu Leu Cys Phe
Trp Ser Leu 1 5 10 tgc tat tgc ttt gct gcg ggg agc ccc gta cct ttt
ggt cca gag gga 339 Cys Tyr Cys Phe Ala Ala Gly Ser Pro Val Pro Phe
Gly Pro Glu Gly 15 20 25 cgg ctg gaa gat aag ctc cac aaa ccc aaa
gct aca cag act gag gtc 387 Arg Leu Glu Asp Lys Leu His Lys Pro Lys
Ala Thr Gln Thr Glu Val 30 35 40 45 aaa cca tct gtg agg ttt aac ctc
cgc acc tcc aag gac cca gag cat 435 Lys Pro Ser Val Arg Phe Asn Leu
Arg Thr Ser Lys Asp Pro Glu His 50 55 60 gaa gga tgc tac ctc tcc
gtc ggc cac agc cag ccc tta gaa gac tgc 483 Glu Gly Cys Tyr Leu Ser
Val Gly His Ser Gln Pro Leu Glu Asp Cys 65 70 75 agt ttc aac atg
aca gct aaa acc ttt ttc atc att cac gga tgg acg 531 Ser Phe Asn Met
Thr Ala Lys Thr Phe Phe Ile Ile His Gly Trp Thr 80 85 90 atg agc
ggt atc ttt gaa aac tgg ctg cac aaa ctc gtg tca gcc ctg 579 Met Ser
Gly Ile Phe Glu Asn Trp Leu His Lys Leu Val Ser Ala Leu 95 100 105
cac aca aga gag aaa gac gcc aat gta gtt gtg gtt gac tgg ctc ccc 627
His Thr Arg Glu Lys Asp Ala Asn Val Val Val Val Asp Trp Leu Pro 110
115 120 125 ctg gcc cac cag ctt tac acg gat gcg gtc aat aat acc agg
gtg gtg 675 Leu Ala His Gln Leu Tyr Thr Asp Ala Val Asn Asn Thr Arg
Val Val 130 135 140 gga cac agc att gcc agg atg ctc gac tgg ctg cag
gag aag gac gat 723 Gly His Ser Ile Ala Arg Met Leu Asp Trp Leu Gln
Glu Lys Asp Asp 145 150 155 ttt tct ctc ggg aat gtc cac ttg atc ggc
tac agc ctc gga gcg cac 771 Phe Ser Leu Gly Asn Val His Leu Ile Gly
Tyr Ser Leu Gly Ala His 160 165 170 gtg gcc ggg tat gca ggc aac ttc
gtg aaa gga acg gtg ggc cga atc 819 Val Ala Gly Tyr Ala Gly Asn Phe
Val Lys Gly Thr Val Gly Arg Ile 175 180 185 aca ggt ttg gat cct gcc
ggg ccc atg ttt gaa ggg gcc gac atc cac 867 Thr Gly Leu Asp Pro Ala
Gly Pro Met Phe Glu Gly Ala Asp Ile His 190 195 200 205 aag agg ctc
tct ccg gac gat gca gat ttt gtg gat gtc ctc cac acc 915 Lys Arg Leu
Ser Pro Asp Asp Ala Asp Phe Val Asp Val Leu His Thr 210 215 220 tac
acg cgt tcc ttc ggc ttg agc att ggt att cag atg cct gtg ggc 963 Tyr
Thr Arg Ser Phe Gly Leu Ser Ile Gly Ile Gln Met Pro Val Gly 225 230
235 cac att gac atc tac ccc aat ggg ggt gac ttc cag cca ggc tgt gga
1011 His Ile Asp Ile Tyr Pro Asn Gly Gly Asp Phe Gln Pro Gly Cys
Gly 240 245 250 ctc aac gat gtc ttg gga tca att gca tat gga aca atc
aca gag gtg 1059 Leu Asn Asp Val Leu Gly Ser Ile Ala Tyr Gly Thr
Ile Thr Glu Val 255 260 265 gta aaa tgt gag cat gag cga gcc gtc cac
ctc ttt gtt gac tct ctg 1107 Val Lys Cys Glu His Glu Arg Ala Val
His Leu Phe Val Asp Ser Leu 270 275 280 285 gtg aat cag gac aag ccg
agt ttt gcc ttc cag tgc act gac tcc aat 1155 Val Asn Gln Asp Lys
Pro Ser Phe Ala Phe Gln Cys Thr Asp Ser Asn 290 295 300 cgc ttc aaa
aag ggg atc tgt ctg agc tgc cgc aag aac cgt tgt aat 1203 Arg Phe
Lys Lys Gly Ile Cys Leu Ser Cys Arg Lys Asn Arg Cys Asn 305 310 315
agc att ggc tac aat gcc aag aaa atg agg aac aag agg aac agc aaa
1251 Ser Ile Gly Tyr Asn Ala Lys Lys Met Arg Asn Lys Arg Asn Ser
Lys 320 325 330 atg tac cta aaa acc cgg gca ggc atg cct ttc aga gtt
tac cat tat 1299 Met Tyr Leu Lys Thr Arg Ala Gly Met Pro Phe Arg
Val Tyr His Tyr 335 340 345 cag atg aaa atc cat gtc ttc agt tac aag
aac atg gga gaa att gag 1347 Gln Met Lys Ile His Val Phe Ser Tyr
Lys Asn Met Gly Glu Ile Glu 350 355 360 365 ccc acc ttt tac gtc acc
ctt tat ggc act aat gca gat tcc cag act 1395 Pro Thr Phe Tyr Val
Thr Leu Tyr Gly Thr Asn Ala Asp Ser Gln Thr 370 375 380 ctg cca ctg
gaa ata gtg gag cgg atc gag cag aat gcc acc aac acc 1443 Leu Pro
Leu Glu Ile Val Glu Arg Ile Glu Gln Asn Ala Thr Asn Thr 385 390 395
ttc ctg gtc tac acc gag gag gac ttg gga gac ctc ttg aag atc cag
1491 Phe Leu Val Tyr Thr Glu Glu Asp Leu Gly Asp Leu Leu Lys Ile
Gln 400 405 410 ctc acc tgg gag ggg gcc tct cag tct tgg tac aac ctg
tgg aag gag 1539 Leu Thr Trp Glu Gly Ala Ser Gln Ser Trp Tyr Asn
Leu Trp Lys Glu 415 420 425 ttt cgc agc tac ctg tct caa ccc cgc aac
ccc gga cgg gag ctg aat 1587 Phe Arg Ser Tyr Leu Ser Gln Pro Arg
Asn Pro Gly Arg Glu Leu Asn 430 435 440 445 atc agg cgc atc cgg gtg
aag tct ggg gaa acc cag cgg aaa ctg aca 1635 Ile Arg Arg Ile Arg
Val Lys Ser Gly Glu Thr Gln Arg Lys Leu Thr 450 455 460 ttt tgt aca
gaa gac cct gag aac acc agc ata tcc cca ggc cgg gag 1683 Phe Cys
Thr Glu Asp Pro Glu Asn Thr Ser Ile Ser Pro Gly Arg Glu 465 470 475
ctc tgg ttt cgc aag tgt cgg gat ggc tgg agg atg aaa aac gaa acc
1731 Leu Trp Phe Arg Lys Cys Arg Asp Gly Trp Arg Met Lys Asn Glu
Thr 480 485 490 agt ccc act gtg gag ctt ccc tga gggtgcccgg
gcaagtcttg ccagcaaggc 1785 Ser Pro Thr Val Glu Leu Pro 495 500
agcaagactt cctgctatcc aagcccatgg aggaaagtta ctgctgagga cccacccaat
1845 ggaaggattc ttctcagcct tgaccctgga gcactgggaa caactggtct
cctgtgatgg 1905 ctgggactcc tcgcgggagg ggactgcgct gctatagctc
ttgctgcctc tcttgaatag 1965 ctctaactcc aaacctctgt ccacacctcc
agagcaccaa gtccagattt gtgtgtaagc 2025 agctgggtgc ctggggcctc
tcgtgcacac tggattggtt tctcagttgc tgggcgagcc 2085 tgtactctgc
ctgacgagga acgctggctc cgaagaggcc ctgtgtagaa ggctgtcagc 2145
tgctcagcct gctttgagcc tcagtgagaa gtccttccga caggagctga ctcatgtcag
2205 gatggcaggc ctggtatctt gctcgggccc tagctgttgg ggttctcatg
ggttgcactg 2265 accatactgc ttacgtctta gccattccgt cctgctcccc
agctcactct ctgaagcaca 2325 catcattggc tttcctattt ttctgttcat
tttttaattg agcaaatgtc tattgaacac 2385 ttaaaattaa ttagaatgtg
gtaatggaca tattactgag cctctccatt tggaacccag 2445 tggagttggg
atttctagac cctctttctg tttggatggt gtatgtgtat atgcatgggg 2505
aaaggcacct ggggcctggg ggaggctata ggatataagc attagggacc ctgaggcttt
2565 aagtggtttc tatttcttct tagttattat gtgccacctt cttagttatt
atgtgccacc 2625 tcccctatga gtgacgtgtt tgatcactag cagaatagca
agcagagtat cattcatgct 2685 ggggccagaa tgatggccgg ttgccagata
taactgcttt ggagcaaatc tcttctgttt 2745 agagagatag aagttatgac
atatgtaata cacatctgtg tacacagaaa ccggcacctg 2805 ccagacagag
ctggttctaa gatttaatac agtgcttttt ttcctctttg aaatatttta 2865
ctttaatacc agtgcctttt cttgttgaac ttcttggaaa agccaccaat tctagatctt
2925 gatttgaatt aatacacaca atatctgaga cacttacact tttcaaaaga
tttgtgtatg 2985 cattgcctaa ttagagtagg gggagaaggg caactattat
tatccctatt ttacaaaact 3045 gaggcttagt gaggttcagc cacatgccta
gacttatata ctagttagtg gtgcagccag 3105 ggagaggact cagatttcct
ggaggcaaag tctatctctg aaactccatg aagacttttg 3165 cagccagttc
ccaccaatat gccccagacg tgagacaaac aaggactttt ttttttatat 3225
agagccatcc ataaaatcct aagccctttt attaatgtat aaccaggaga acatctgtgc
3285 caacggttgg actttttatg gctgagattc gggaggaagt gtgacaccaa
gcaggagagg 3345 aagaatgatt ttctttgtac ttaggttttc taaggacatt
gttttaatct gtatcgtgcc 3405 aaagttgtat cactgttaaa cttctgaaga
cataaccagt tgagtcttat ttcaagatat 3465 gttctcaagc caattgtgtg
cttctcttgt ttctgtgatt gctttctagc caaagcgaag 3525 cttgtacagg
ttgagtatcc cttatccaaa atgcttggaa ccagaagtgt ttcaaatttt 3585
agattatttt cagattttgg aatgtttgca tatacataat gagatatttt gggaatagga
3645 cccgagccta aacacaaaat tcattgatgt gtcagttaca ccttatccac
atagcctgag 3705 ggtaatttta tacgatattt taaatagttg tgtacatgaa
gcatggtttg tggtaactta 3765 tgtgaggggt tttcccattt tttgtcttgt
tggtgctcaa aaagttttgg attttggagc 3825 atttcggatt ttggattttt
ggattagggt tgctcaaccc atattattgg ctgtacatcc 3885 tggtcacttc
tgacttctgt ttttactaat ggaagctttg ca 3927 <210> SEQ ID NO 5
<211> LENGTH: 19 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: PCR Primer <400> SEQUENCE: 5 ccggacggga
gctgaatat 19 <210> SEQ ID NO 6 <211> LENGTH: 19
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR Primer
<400> SEQUENCE: 6 cagtttccgc tgggtttcc 19 <210> SEQ ID
NO 7 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR Probe <400> SEQUENCE: 7 aggcgcatcc
gggtgaagtc 20 <210> SEQ ID NO 8 <211> LENGTH: 19
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR Primer
<400> SEQUENCE: 8 gaaggtgaag gtcggagtc 19 <210> SEQ ID
NO 9 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR Primer <400> SEQUENCE: 9 gaagatggtg
atgggatttc 20 <210> SEQ ID NO 10 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR Probe
<400> SEQUENCE: 10 caagcttccc gttctcagcc 20 <210> SEQ
ID NO 11 <211> LENGTH: 3610 <212> TYPE: DNA <213>
ORGANISM: Mus musculus <220> FEATURE: <221> NAME/KEY:
CDS <222> LOCATION: (144)...(1646) <400> SEQUENCE: 11
ccacgcgtcc gcgacacccg gcctgtccac ttctagtctc tggaggtttt agtggtttca
60 aaccaaacca acccaaacca acccaacaac aaaaaagccc aaaccaaaaa
cctgcttgag 120 aggagggggc gtggcgggga agg atg cga aac acg gtt ttc
ctg ctc ggc ttt 173 Met Arg Asn Thr Val Phe Leu Leu Gly Phe 1 5 10
tgg agc gtc tat tgt tac ttc ccg gcg gga agt atc aca acc ttg cgt 221
Trp Ser Val Tyr Cys Tyr Phe Pro Ala Gly Ser Ile Thr Thr Leu Arg 15
20 25 ccc gag ggg tcg ctg cga gat gag cat cat aaa ccc act gga gta
cca 269 Pro Glu Gly Ser Leu Arg Asp Glu His His Lys Pro Thr Gly Val
Pro 30 35 40 gct acc gcc aga ccc tct gtg gct ttt aac atc cgc act
tct aag gac 317 Ala Thr Ala Arg Pro Ser Val Ala Phe Asn Ile Arg Thr
Ser Lys Asp 45 50 55 cca gag cag gaa ggg tgt aat ctc tcc ctt ggt
gac agc aaa ctc tta 365 Pro Glu Gln Glu Gly Cys Asn Leu Ser Leu Gly
Asp Ser Lys Leu Leu 60 65 70 gaa aac tgt ggc ttc aac atg aca gcc
aaa acc ttc ttc atc att cat 413 Glu Asn Cys Gly Phe Asn Met Thr Ala
Lys Thr Phe Phe Ile Ile His 75 80 85 90 gga tgg acg atg agt ggc atg
ttt gag agc tgg ctg cat aaa ctt gta 461 Gly Trp Thr Met Ser Gly Met
Phe Glu Ser Trp Leu His Lys Leu Val 95 100 105 tca gcc ctg cag atg
aga gag aaa gat gct aac gtc gtg gtg gtt gac 509 Ser Ala Leu Gln Met
Arg Glu Lys Asp Ala Asn Val Val Val Val Asp 110 115 120 tgg ctg ccc
ctg gct cat cag ctg tac acg gat gca gtc aat aac acc 557 Trp Leu Pro
Leu Ala His Gln Leu Tyr Thr Asp Ala Val Asn Asn Thr 125 130 135 agg
gtg gtg gga cag aga gta gct ggg atg ctt gac tgg ctg cag gag 605 Arg
Val Val Gly Gln Arg Val Ala Gly Met Leu Asp Trp Leu Gln Glu 140 145
150 aag gaa gag ttc tct ctt ggg aac gtt cac ttg att ggc tac agc ctt
653 Lys Glu Glu Phe Ser Leu Gly Asn Val His Leu Ile Gly Tyr Ser Leu
155 160 165 170 gga gca cac gtg gct gga tac gct ggc aac ttt gtg aaa
gga aca gtg 701 Gly Ala His Val Ala Gly Tyr Ala Gly Asn Phe Val Lys
Gly Thr Val 175 180 185 ggc agg atc act ggt ctg gat ccc gcg ggt ccc
atg ttt gaa ggg gtg 749 Gly Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro
Met Phe Glu Gly Val 190 195 200 gac atc aac aga agg ctg tcc ccg gac
gat gca gac ttt gtg gat gtc 797 Asp Ile Asn Arg Arg Leu Ser Pro Asp
Asp Ala Asp Phe Val Asp Val 205 210 215 ctg cat acc tac acg ctg tcc
ttt ggc ttg agc att ggg att cgg atg 845 Leu His Thr Tyr Thr Leu Ser
Phe Gly Leu Ser Ile Gly Ile Arg Met 220 225 230 cct gtg ggt cac att
gac atc tat ccc aat ggc ggt gac ttc cag cca 893 Pro Val Gly His Ile
Asp Ile Tyr Pro Asn Gly Gly Asp Phe Gln Pro 235 240 245 250 ggc tgt
gga ttc aat gat gtc atc gga tct ttt gca tat gga aca atc 941 Gly Cys
Gly Phe Asn Asp Val Ile Gly Ser Phe Ala Tyr Gly Thr Ile 255 260 265
tca gag atg gtg aaa tgc gag cac gag cga gcc gta cac ctc ttt gtc 989
Ser Glu Met Val Lys Cys Glu His Glu Arg Ala Val His Leu Phe Val 270
275 280 gac tct ctg gtg aat cag gac aag ccc agc ttt gcc ttc cag tgc
aca 1037 Asp Ser Leu Val Asn Gln Asp Lys Pro Ser Phe Ala Phe Gln
Cys Thr 285 290 295 gac tcc agc cgc ttc aaa agg gga atc tgc ctc agc
tgc cgg aag aac 1085 Asp Ser Ser Arg Phe Lys Arg Gly Ile Cys Leu
Ser Cys Arg Lys Asn 300 305 310 cgt tgt aat aac att ggc tac aac gcc
aag aaa atg aga aag aag agg 1133 Arg Cys Asn Asn Ile Gly Tyr Asn
Ala Lys Lys Met Arg Lys Lys Arg 315 320 325 330 aat agc aaa atg tat
tta aaa acc cgg gct ggc atg cct ttc aaa gtt 1181 Asn Ser Lys Met
Tyr Leu Lys Thr Arg Ala Gly Met Pro Phe Lys Val 335 340 345 tac cat
tac cag ctg aaa gtt cac atg ttc tct tac aat aac agt ggg 1229 Tyr
His Tyr Gln Leu Lys Val His Met Phe Ser Tyr Asn Asn Ser Gly 350 355
360 gac acc cag ccc acc ctc tac att acc ctg tat ggt agc aac gca gac
1277 Asp Thr Gln Pro Thr Leu Tyr Ile Thr Leu Tyr Gly Ser Asn Ala
Asp 365 370 375 tcc cag aac ctg ccc ttg gaa ata gtg gag aag att gag
ctg aat gcc 1325 Ser Gln Asn Leu Pro Leu Glu Ile Val Glu Lys Ile
Glu Leu Asn Ala 380 385 390 aca aac acc ttc ctt gtc tac act gag gag
gac ttg ggc gat ctc ttg 1373 Thr Asn Thr Phe Leu Val Tyr Thr Glu
Glu Asp Leu Gly Asp Leu Leu 395 400 405 410 aag atg cga ctt acc tgg
gag ggg gta gcc cat tcc tgg tac aac ctg 1421 Lys Met Arg Leu Thr
Trp Glu Gly Val Ala His Ser Trp Tyr Asn Leu 415 420 425 tgg aat gag
ttt cgc aac tac ctg tct caa ccc agc aac ccc tcg agg 1469 Trp Asn
Glu Phe Arg Asn Tyr Leu Ser Gln Pro Ser Asn Pro Ser Arg 430 435 440
gag ctg tac atc cgg cga att cgt gtc aaa tct ggg gaa acc cag cgc
1517 Glu Leu Tyr Ile Arg Arg Ile Arg Val Lys Ser Gly Glu Thr Gln
Arg 445 450 455 aaa gtg aca ttt tgc act caa gac cca acg aag agt agc
atc tcc cct 1565 Lys Val Thr Phe Cys Thr Gln Asp Pro Thr Lys Ser
Ser Ile Ser Pro 460 465 470 ggc cag gag ctg tgg ttt cac aag tgt cag
gat ggc tgg aaa atg aaa 1613 Gly Gln Glu Leu Trp Phe His Lys Cys
Gln Asp Gly Trp Lys Met Lys 475 480 485 490 aac aaa acc agt ccc ttt
gtg aac ttg gcc tga gggcccaaga agtcctggcg 1666 Asn Lys Thr Ser Pro
Phe Val Asn Leu Ala * 495 500 tccacaccca caccccactg tccacgcaca
tggaggaaaa gttactgctg aagacccact 1726 cgatggacga tctcagcctt
gagccccacg aggagcttgc ttgctgggct catcctgtct 1786 cccctgacaa
ctgtgacttc tcctggagag gcctgtgcac tgctgaagtt cttgctgatg 1846
attctagctg taaacctttg ttgccgccgc aggaagctga ggccagcttg tgtgtgagca
1906 ctggagtgtc cagagccctg cacactcggg gtggggggcg gggtactctc
cctgtcgcta 1966 ggtgagcact ggctttgtcc aacatcaggg aacacaaggc
tctgaagtgg ccctgtgtgg 2026 aaggttggca gctgcctggc ctcactgaac
cttagtgaca agtctttgcc tcaggagctg 2086 actcatgcca tagagagggg
actgtagacc aggctggggc tgctgccctc ccacacgagg 2146 tactgatgga
tcctggttct attctgggta tttcatcctg ccttccagag caccttctga 2206
agttcacatc gttggcattt cctttttatg ttatgcatac tttggctgaa caaacattta
2266 ttgggcactt cagctcatta gcaccaggca tgtatagaca catgactcaa
cttcagcatt 2326 tggagccagc gagaccagga tccctggaat ctctcaagtt
cactggcccc tgagaatgcc 2386 tgtgttagtt aaagacagat gggatcaagg
cgagggctac aggctgagag agcttgagct 2446 cagaggcttt tatgaaccgt
ttcctctgag ggccaccctt gatctctagc agaacagcaa 2506 gcagaacacc
gtgcatgctg gccacagcag tggagccaag tctctgctgg ttacggagct 2566
atacggtact gcaggagttc tacatacctg ctgcgcagag accagccccg tggacagagc
2626 tggcatgatg gttgctacag tgctctttct cccatgaagt ctttgctttt
atatcagtgc 2686 cttatctgtt aagctcctgg aggaaagccc cctattctag
atctttatgt gaatggataa 2746 atgtgacacc cgagacaccc tttagtagtt
tgacagcttg cgtgtgtgcc gcctaattag 2806 agcacaggga gcagggcagc
tgttattcct gttttaccaa gtcaaggctt agggaagttc 2866 agccacctgc
ttagatgata tatcaaggtg gcagtggaag ggggtgagct aaggacccag 2926
caaggtttcc tggaggcaaa gtttatgaaa tcctttctgt aactccataa agatgtctgc
2986 agctatttcc tacccagatg ttcctgatgt gataagcagg ggactttttt
ttttttcctt 3046 cagatgctat ccataaaatc caagcccttt cttaagatac
aagcagaaga acggttgcgt 3106 ttttgtgggt gtgctgtcag cctggggggt
ggggggtggg gggtgggaga gcgattactc 3166 tgtgtttagg tttgtcacgc
acattctttg catctgtatt gtaccagctt tatagcactg 3226 tttcatgcca
aagttctgat gacgtaacca gttgaccctt cacacagagt gccctttccc 3286
cccctccccc ctccccatgc ttctgtgatt gctctgtagc catgtgaagc ttgctagccg
3346 cggctgtaca tcctgtgact tccaccttgg gtttagtaat gggagcttga
gattggagag 3406 ctgagtcctc tgtgggttct gtatttatcc atttggcttg
aagctttgtt tatatatcgg 3466 ctgctttttt ttttttaaat gctcagacca
ttatttattt cttgagtgta tataagtata 3526 aagacaaatc tatggttagt
ttttacttta agattaaccg atttcaagat ttacaaaaaa 3586 aaacaacaaa
aaaaaaaaaa aaaa 3610 <210> SEQ ID NO 12 <211> LENGTH:
21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR Primer
<400> SEQUENCE: 12 gctgaatgcc acaaacacct t 21 <210> SEQ
ID NO 13 <211> LENGTH: 24 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR Primer <400> SEQUENCE: 13 caggtaagtc
gcatcttcaa gaga 24 <210> SEQ ID NO 14 <211> LENGTH: 28
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR Probe
<400> SEQUENCE: 14 cttgtctaca ctgaggagga cttgggcg 28
<210> SEQ ID NO 15 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR Primer <400> SEQUENCE: 15
ggcaaattca acggcacagt 20 <210> SEQ ID NO 16 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
Primer <400> SEQUENCE: 16 gggtctcgct cctggaagat 20
<210> SEQ ID NO 17 <211> LENGTH: 27 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR Probe <400> SEQUENCE: 17
aaggccgaga atgggaagct tgtcatc 27 <210> SEQ ID NO 18
<211> LENGTH: 75033 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(75033) <223> OTHER
INFORMATION: n = A,T,C or G <400> SEQUENCE: 18 agagagtgtg
gctttgagcc ttggagagga tgctctcctt ctccagggat cgcctcccca 60
gcggacgcag agtttcaggg aaatgtccgc ctccgccact tgggatggca gtggggagag
120 gaggatctgg gtgtccggag gagggcagtg ggagaaagct ggagctgctg
gagtcgcagc 180 tgcctgcgga gcgggcccgg gaggaagcgg ggccgagcgt
gcggcgtcca cgcggtgagt 240 gtgcagcgct ttcattcaaa ctttctccag
tctcggttcc ggcgtcagca aggtgtgacc 300 aatcagagcc cagagacggg
aataaattat gcaaatcacc atctggcgat gggtcagatg 360 actcccatac
ttttaaaaac tacctctata ggagcgtgac agcagcgagt ccttgcctcc 420
cggcggctca ggacgagggc agatctcgtt ctggggcaag ccgttgacac tcgctccctg
480 ccaccgcccg ggctccgtgc cgccaagttt tcattttcca ccttctctgc
ctccagtccc 540 ccagcccctg gccgagagaa gggtcttacc ggccgggatt
gctggaaaca ccaagaggtg 600 gtttttgttt tttaaaactt ctgtttcttg
ggagggggtg tggcggggca ggatgagcaa 660 ctccgttcct ctgctctgtt
tctggagcct ctgctattgc tttgctgcgg ggagccccgt 720 accttttggt
ccagagggac ggctggaagg taacgtgaat ttgtttttat tccccccagc 780
cacttctctg tgctgggtcc cctctgtctt gctgattctt caaaccctcc ttgttcctat
840 gaaattcttc ctttcccact gcgctgcccn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn 900 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn 960 nnnnnnnnng gccgcagtgc gctgtgaatg
agccactgca ctccagcctg ggcaacagag 1020 agattccatc taagaaaaaa
gttcatttaa gttttatagg aaaatcactg aaggttcaaa 1080 agacaaacta
ttcactcaaa aggaaatgat ctcacaaggc ttaaatgtct tctaatctaa 1140
cccaatgctg gctgacagac tcaaatgtgg tgtgactgtt tttaattata ggcttgattt
1200 ctccctaaaa tcagagaaaa tatggttgga gtccataggg gatggagaaa
gaagggataa 1260 aagatgagga aggcaaaggc cagatcatgg aaggctctta
tatcatcccc aaatatttgg 1320 aacaggggcc acaggaaaaa aaaaacccaa
aaaatgacat gatcattctg acagccattt 1380 tagaaaaatg actctgtcag
ggccaggcgt ggtggctcac gtctgtaatc ccagcacttt 1440 gggaggctga
ggtgggcgga tcacatgagg tcaggagttc aagaccagcc tggccaacat 1500
gacaaaatcc tatctctatt aaaaatacaa aaattagctg ggcatcgtgg tgggtgcctg
1560 taatcccagc tgcttgggag gctgaggcag gagaatcgct tgaacctgga
ggcagaggtt 1620 gcagtgagct gagatcacac cactgcactc cagcctgggg
ccacagagtg agaccttgtc 1680 tcaaaaaaaa aaaaaaaaag aaagaaagaa
agaaagaaaa agaaaagaaa agaaaaatga 1740 ctgtcaggaa tatggaggat
atattaaagt gcagaaataa ttagggcaag aagaccactt 1800 aaaagaataa
tccagatttt gttaaataat tgtatgtgca aagacaagaa gaggggagtc 1860
tctcatcttt ctggtttaag atcctaggtg tatggggaag tcgccaaaca aggaagggag
1920 aaaggcaggg tcgcctaggg atgcagagct tggtcacaga aggctgcctt
ggatcccagg 1980 gctgccactc ccagctgccg gaccttggat ttgccgggga
gttccttttt tttcttcttc 2040 tttttaacac attgtagcag ccagatcaac
ttcatcattt acaaatagtt gtcctaagga 2100 ttacttgagg aaatgcatgt
aaaaacactg aaaatactgc ctagaatcta gtaagcttat 2160 agaatcattg
tctgttactc ttgtcaccat gcaacataaa agaggaaccc ggaggagaag 2220
acaaagagtt ctgtttaagg gcatgttagg tttcaaataa cctcaggtct tcagggacct
2280 cccagaaagg atgtccaggg agtagtttgc tatcagggtc tagctcagga
gacagatgtg 2340 gcgctggggt attaatctgg gagttagcat gcagttgaaa
gctcatgtga ggggagggaa 2400 ttaccgagga aacaccatgg aatccagcat
cagcaatgga agtggagtcg aggggagaga 2460 cttagggctg aggtctccta
cactgaggtc aaggaagcaa gtgagcctag cctggagtct 2520 actctcctag
agtttgagct gcctagaagg gtggtgccat gaaatagaag ccctaacaaa 2580
agctaagtgc atcactgact atgagggaat aaccagagag atgacctggg gaaggaaaaa
2640 agggaagaaa atgccaaaag gttttctcct ccagatgaag atctagaagc
agcggggaaa 2700 acgaggatat tgaaccagac ccttcagtta gcgcattttt
cacacaggtt ataatacaat 2760 tgattggatg acattcccat cctgagaatt
tcctgattac cataattacg tctcatcctt 2820 tcatcttttt aattggccat
ttacaaacca ctttcaggag tacagggcca cataatcaaa 2880 cctaactaat
gtgacgaata aataaaatgt ttctttcata tctaataata cgtagcctgt 2940
cctagaacta caaacctgtt tttaattgac tgacatttaa aaccctgaat ttttatttct
3000 gtatacaaaa aagagaactt tgagacagtc cctaagtagg caattcgttt
tcacacgttc 3060 ttaaaacata ttccacactc ccttcgcttt ccgccttcct
gcctcctcag atctcgtttc 3120 ttcggctacg aatctcgcga gaagtcaagt
tctcatgagt tctcccaaaa tccaccgctc 3180 ttcctctttc cctaagcagc
ctgaggtgag tgtttctcct gcgttgctcc gagggcccaa 3240 tcctcctgcc
atcgccgcca tcctggcttc gggggcgccg gcctccaggc ccccgggagg 3300
agaactccta gggctactaa atcctcgctg gaggcggtgg cttcttatgc gggaggacgt
3360 ggcggagggc ctgactttgg gagccggggt cagtcggcct ctgaggtccg
cagagggacg 3420 tgatgggcgg gaatggggac taccgggctc ctccactggt
gggggcgccg gcccgccgtg 3480 gggtgcgggc cgcctggggt ccgtgcggac
tccggaggtc cggtgtctag tggtgagtgg 3540 tggccgcaac gaggaaaaag
ttttggggga aagaaaagtc gggtggaggc gtaacacgtt 3600 actacaagag
tgttgcgtac aggagggctc ttaaagtggg tcatagcccg aaggtgttga 3660
gagagacggc actcactacc tgcagccctg acagcaaagg ggtttctgta gagcgggagg
3720 gaggaggtgt agagggttac ggttgagttg tgccctgcgg atgcgtcgag
tcattttacg 3780 cctggaagat ccagcattgg attgaaacag gctgtatttt
cttccaaagg gttgactgga 3840 ttggtgaggc ccgtgtggct acttctgtgg
aagcagtgct gtagttactg gaagataaaa 3900 gggaaagcaa gcccttggtg
ggggaaagta tggctgcgat gatggcattt cttaggacac 3960 ctttggatta
ataatgaaaa caactactct ctgagcagct gttcgaatca tctgatattt 4020
atactgaatg agttactgta agtacgtatt gacagaatta cactgtactt tcctctaggt
4080 gatctgtgaa aatggttcgc tattcacttg acccggagaa ccccacgaaa
tgtaagtgga 4140 caggaggtag atacccattt cctacttggg gcttggcata
agataccaaa aattaaccaa 4200 aacgttttat ttcctagcat gcaaatcaag
aggttccaat cttcgtgttc actttaaggt 4260 atgcgattca tagttgtgat
ccaacagttc ctcatgttcc actcaaaaaa ggtagctgca 4320 gtgatgactt
tcttaggaca cctttggatt taccgtgaaa attaataaat tctgagcagc 4380
caccttatat ttaggcattg atgatcaggg tgtaaggatg tagcgtttgt gaaattgaga
4440 agtagtacca gaaaaccatt tgaaaaccta gtgtgcagat caagatgggg
cattttaatt 4500 gtaattacat gatgatggaa tttaaacgtt ttatagtgaa
taaatggagt tttggagttt 4560 tctctagctt caacgaagtt tacctggctt
ttagtcacaa gtttttttaa ttgccttgcc 4620 cccaaagaat agaaataact
cgacattttg aaaagctgaa aattgaaaat ttaacgttta 4680 ctttaaaaat
taaagctttg atctagttaa ccaacacttt attcttcata cttagaacac 4740
tcgtgaaact gctcaggcca tcaagggtat gcatatacga aaagccacga agtatctgaa
4800 agatgtcact ttacagaaac agtgtgtacc attccgacgt tacaatggtg
gagttggcag 4860 gtgtgcgcag gtgagaattc ttagttgcca tttgaaaaga
cagattttaa tggaaaagtg 4920 atgggatagg ataagaatgg ctaagatctg
tgctgatgaa cctatttctg gttgctgtaa 4980 tgacaggaca ccttggattg
atggtgaaat aaaccatatc ctaagaaacc gtgatatcag 5040 ataaattcat
cttggctgta atgttaattt aaatcaagga aaatgactca tcatctccat 5100
tttctttcag gcaagcaatg gggctggaca caaggtcggt ggcccaaaaa gagtgctgaa
5160 ttattgctgc acatgcttaa aaacgcagag agtaatgctg aacttaaggt
acccaaacca 5220 ctaacatcct gtgcaacttg ggtggttgtt taattaatgt
tggctgttca gatttatgtc 5280 cttgattttc ttgttttcag taattaactc
atttaggatt ttttaaattt ctacctgcag 5340 tttccacaga atgaaactat
ttccttttat tttttttgag tccctttatg gcaaaattct 5400 gtgaagatcc
agaagcgtgc tctgtggtct ctttaagcct aacacttagt atttctagtt 5460
ttctgctgtc tttttacact ggaggtactt taccaggggc ttttacccct ttttgtgaca
5520 tacacctttg gtagtatgat taattatcaa aatgattgcc ttagcagtga
ttaatgtggt 5580 ttgtggccta ccttcataat ggagagtcat gttgcatttc
agaaagaaat tgtttaaaat 5640 ttcaaaaagt ttaaacaatg acaaacttgt
gttgacaaaa cacaaatttc tccattttgt 5700 atattaccca ttagcctttt
gcatttgaag gtctgggcca gaactggaat tagtttaggt 5760 ctgtatggct
ccaaaccttc taagccatgc tgagaaattt tatcatcaag acttcaaatt 5820
gggttcttcc ttacccctca gctctccacc cgtctaagga tctttgggaa ggccactcat
5880 agacaaaatg tatagcacac tgagtttggt ggcaatttag acatgtaaag
gtgaaggcag 5940 acaactggtt aaaaaaatgc tatttgcaga ataaaaggat
tgcctttcaa aaatgatttc 6000 attgaggcag gactctggag caagcctggg
aattcatatt tagcaatgat agtttgtggt 6060 gttttactaa ttaaggatgt
tcctggtttc attctccttc ctttcttccc cagggtttag 6120 atgtagattc
tctggtcatt gagcatatcc aagtgaacaa agcacctaag atgcgccgcc 6180
ggacctacag agctcatggt cggattaacc catacatgag ctctccctgc cacattgaga
6240 tgatccttac ggaaaaggaa cagattgttc ctaaaccaga agaggaggtt
gcccagaaga 6300 aaaaggtaaa taagtagttg ctcggttttg tttgtgatag
tagaaagatt tgtggttgct 6360 gtgatgacta tcttaggaca cctttggaat
aactatgaaa gaaaactatt ctgagcaacc 6420 cttttcacct gtcttatttt
ggcttttgta agtttgtttc ttgactaata ataaatggta 6480 agttttctgt
aatcccagca ctttgggagg ctgaggtggg tggatcacaa ggtcaggaga 6540
tcgagaccat cctggctaac acagtgaaac cccgtctcta ctaaaaatgc aaaaaaaaat
6600 tagctgggcg tggtggcggg tatctgtagt cccagctact caggaggctg
aggcaggaga 6660 atggcatgaa cccgggagga ggaactagga gtgagccgag
atcgcgccac tgcactccag 6720 cctgggtgac agagcgagac gctgtctcaa
aaaaaaaaaa aactggtagt tttatattca 6780 gtacctcagg cccgtatgat
tatctgctga tggccccact tagatgtact tagccacttc 6840 aaaatgggcc
ctctccccaa atctaagnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6960 nnnnnnnata atatatagtc actttactcc taaatatata ttatatagca
tatataatat 7020 gctatattat atatcatata taatatgcta tattatatat
catatactat attatatatc 7080 atatataata gtatatgtat atttaggagg
aaagcgattc tggaatagag tgtagaattt 7140 gtggattatc agcctgagaa
gggacaaagg gcattagggc atcatttaca cattatgagg 7200 gtgttagaac
agaatatggt tatcatggat tttcagatcc actaatgttt actttccatt 7260
taaggcacat caaatcaaga gatagtcagt acacataaaa gaggagattg actttatgta
7320 tttatcaaat atttcacaaa tataaaatat tgagcatatc atgttttatt
tatttattta 7380 tttatttatt tatttattta tttattggtg acagagtctc
cctctgttgc ccaggctgaa 7440 gtacagtgac atgattgtat aatagctcac
tgcaacttca aaatcctgga tttcaggtga 7500 tcctcctgcc tcagccttct
gagtagctgg gactacaggc ttattagcta gtagtagcct 7560 ggctaatttg
taaatttttg tagagacaga gttttgcttt gttgtcaagg ctggtcttga 7620
actcagcttc tggaaatcct tgtaccttag cctcccaaag tgctggaatt acaggcatga
7680 gccacagttc ctggcctgtt accaagtatt ttttaatgtt tactagtttg
atgggtaaaa 7740 atgatatatt attgttttaa ttagcatatt gtactcagaa
tttagtctga agatcttttc 7800 atatatttat tagctgtgag accttggcta
tttcagcaag tattttttga gtaatttctc 7860 tttagcagta tgctggagat
tgattaggga taaggaagaa gtgtaaggcc tgattcatgc 7920 ctctcaggaa
taatctacct ggggagatat gttatatgta ctacagcaaa ataacatttc 7980
aaggcagctt ttacgtaatt gcagctttag gggagtagtg gagagtttta aggggtaaca
8040 gggaggaatg atagaatcag ttttgcacat gttaagattg agttcttgac
tacattgcat 8100 tgaagatagg tcctttgaaa ggtttactac taaaagcatc
agcaatagcc tacttctcat 8160 ttctagcata gagttacata aggatcattg
ttaccaacaa acttactgat tatattatat 8220 atattaccct tgagttaaaa
aaagtctgaa atattttaga gatatcaaca gaactggctt 8280 cctggccaga
ggttgggtct agaaggagaa atttgaaagt agtatcatgg aagccactag 8340
aaaagccagg agatgggatc agttactgac agatttagag aaagaagagc tggaagccaa
8400 gggagtctaa tgatgcccag tgagggcaaa ggcagtagga ctctttggag
attatccaat 8460 agtgttttct actttactct agttttcatt gataagggtc
ttgagagttc caaataaatt 8520 gggagccgac gattgtgcgt gtgtgtttgg
aatccttggc aggaatcatt gcagaagaga 8580 tgccattggg gctcagtttt
ctactttgct ttttgtgggg gagcaggtgg atctttctgg 8640 caagagtgcc
tcagtggcta ctggtcttac tatgtctgaa cttattcctc ctgtatactc 8700
caggtgccca gggtgttgcc ttcactctgt tcctagcagg tagcaccctg ttgttgcttc
8760 ctgtgggagt gagggcttag gcaggggtgt ctgctcaggt gcactagcca
agcttctgtt 8820 agttgcttgt gggccttttt ctggcctttc tgcttttgtg
ccggagttcc tgttcacact 8880 ctttgggatg gtgcccttga aggcccttga
gcctgctctg ggatgctatt tcccttttta 8940 gcccatctcc agctgttttc
tactttatgg ggattcttca cagcttctgg ccgcctgtta 9000 tttttttagc
atggctgtgt aatcactggc tatttaaaaa aatatgattt atattatttc 9060
tagggtttgg tgagaaaaaa cggggaagga ggcactgtac tctttactca attggctgtc
9120 tcgatttttt ttgttaacat tctgttcagt gtctctcctg atatgcttgt
aggctttatt 9180 catactgttt tagaaagatt tcatagtgtt cttggactga
gcagttattt tgatttatta 9240 attttatttt tgatacaaag tcttgctctg
ttgcacagtg cagtggtgta gacgtggctc 9300 actgcagcgt cgaactcctg
ggctcaagcg atccttctga gtagctggga ccacaggctt 9360 gtgccaccac
gcccagctag tttttaaatt ttttgtatag atggggtctt gcccaggctg 9420
gcctcgtact cctgggctca agcaatcctc ctgctctgtc tcccaaagtg ctgggattac
9480 aggtgtacag gtgtttgatt taagacttaa ttttgtggtc tatcctagcc
tctttgaaaa 9540 taaagtttat ttcctataaa ccaatagaaa acagtcatag
gatatgagca ggtaatggtc 9600 ttattcacgg caagagagat gcaaaataaa
attgtattga aaaactgctt tttaaaaaaa 9660 atctaagttg gcaaggatca
gaaagtttga ttaaacaatg gtggctgtgg agtagagaaa 9720 taggcgttgc
tggtgagaat ccaagttggt acaacctctg tagaaggcag ccaggcagta 9780
tctatcaaaa ttacagatgc atataccctt tgacccagca attctatttc tctggattta
9840 tcatatctgt ctactcatac atgtgtgaaa tattttatat gcttatgtaa
gtgatagtat 9900 aagatataag taatgtatat atcttattgg agaatgacat
ttatttttta ttacttggag 9960 aatgatttgt aatagcaaaa gatgtagact
acctaaagtc catcaatatg gtatttgaga 10020 aattataaaa tggaatgtta
cacaattgta aaaaggaatg aagtgcttca tatatggata 10080 tataatgact
tcctatatat tgatgagtgg gaatagcaga gtagagagga atatgtcata 10140
tgctatggtt tgtttaaaaa ggggttgaac atatgtttgt atatacacag aatgtctgtg
10200 gaatgatgcc caagaaactg tgaatgtttt ctctgagttg agaaggtggt
tagaagatgg 10260 gatgggaagg agattttcac tgtctatcct ttgaagcttt
tgtattttgt accatgaata 10320 ttactgatac aaaaagaaca taaaataaac
agaaacatct gacaaatttt gttagtagac 10380 tctttgatag tattgtttct
cgttgttgct tcacctggtg ggaggaggag gttgattcca 10440 aaatcaaatt
ttgttctttt gaaaattcag cattcatgta cttaaactcc tagagtaaaa 10500
ttgcttgctt ttaagttacc acacaaaaaa agtaagatac tggtctattt aactgagaac
10560 aaattgttat gattttcatt tcttttgatc tggtgtcatt tttttcctgt
taattttaat 10620 gaagcacaga gaaggaaaat tgagtacatg gtagagccag
gaggacccat atttaaattg 10680 ctgtcagcaa accaacactc tttgaactaa
cccactttca tccatacagt tagaggtact 10740 tattcagtac actaatatta
gacctacaat cctaactgct aattagcatg agtcccctga 10800 taaatagcac
actgtaaaca agtagtcaag gtctttttta ctcgtttgtt taaacatatg 10860
gtttattgag gcatattcag ggtcacaggg attattggac aaataaaaat aatttgaaag
10920 ctttggctaa aaaggaacta gcaatatcct taaggaggtg gtggaagaca
aaatctgttg 10980 tatactcctc agagttaatg aaattaatgc agaatcccag
aggacccaag aacattactt 11040 attttgcttt tattgaaaaa gttcaatttt
gaataaaatc tgaaagaaat aatttattgg 11100 gtagctggga gaggtggctc
atacctctaa ttccagtgct ttgggaagcc taggcaagag 11160 ggtctcttga
ggccaggaga ttgagattag cctcagcaac atagcaagac gcccatctct 11220
ataaaaaatt taaaaaagtt agcagggtgt gatggcatgt atctgtaatc ccacctactc
11280 agaaggctaa ggcggaagga ttgcttgaat tcaggagttt gaagctacag
tgaattatgt 11340 tcatgccact gcactctagt gtgggtgaca gagtgagacc
ctatctctaa aataagtaaa 11400 taaatttatt ttggaaaact agtctaagtg
aaagaacatt ctgtaatagg acaccgagta 11460 actagaatat gagatcctaa
tatctcatca tgtttaatat ggacgatgaa gtaacaatat 11520 gtaaaaacaa
tcctagtggt tgtgaaagaa agtacctatt agtctgattt gttggcacct 11580
ctctgggaca tgtagattct tttttgtttg tttgtttttg ttttttttga gatggagtgt
11640 tgttcttgtt gcccaggctg gagtgcaatg cacgatctcn nnnnnnnnnn
nnnnnnnnnn 11700 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn 11760 nnnnnnnnnn nnnnnnnnnt ggattccaca
tgtttaggtg tgtccttcaa ccccatcacc 11820 ttttcaccac tgcctgggct
tgatgtgttc tctgtagaag attttttaaa atacagatag 11880 tataaaaatc
cttcctgacc cctcatttgg atatttttta atggtgcctt ttttttaatt 11940
gttgacgttc aagatagact ttaaacaatc tgaaggaaaa taaatcaata tcaatgacag
12000 tcatgcacac tcaagcaatc tgtttcaaag cctaatcatt tgtcatctat
tctcagtgtt 12060 tctattataa tttttattat aataatagta caggctgaat
ccccagcacc tatagcagtg 12120 cctggttcag agtcgatact taaatattta
tggaatgaac actaaatgtt ctctcaaaaa 12180 atgataattc agaaatatct
gtatattgca aaaagtaaaa ggtcttcctt accctcccct 12240 gctccattct
gatgattatg tgaaaggaaa agcctctatc cttggtgaat ctctcattta 12300
gcttttcttt tttaagaagt tgtgtattct ggtggtcttt aacagaagag ggctatgtgt
12360 tattgggggt tcattgccac ctgtaggagg caaaataacc tgtgatgagt
tggccccatt 12420 gaagtaccac acctctagga agccttccct tcctcccctt
ctcttgccct tgtttctgca 12480 agctctgtac aacacttctt atccgggtga
ccttgcccta caggtagctg gctacctgct 12540 gtgtctttca caggatggtg
agctccttgt agacagtgct gtctttatct tgccacctcc 12600 cacagtgcct
tggagggtac agttgctaaa cgttttggaa ctaaacagaa aaaaacacag 12660
tacaataaga aattaccata atgctaaatc aacaaattac tcgaatctct tcccctgaca
12720 ctttagtagc tcttgaaagg gcaatttcag tgatcttgtc aaacagctaa
gtcacatggt 12780 gacctagaag agggcttgga agtttgagtc attgccgttc
aatactcttt cctctagaca 12840 tcctgacccc catcctctgc aaaaccatgg
gcagtgcaga gtaggtcaca agtattgtgt 12900 ttttatttgt ttgtttgttt
ttagagacgg gatcttgctg tgttgcccag gctggtcttg 12960 aactcctggg
ctcaagtgat ccccccaccc tggcctccca aagtcctggg attataggtg 13020
tgagccaaca tgcctggcct gagttgtaaa tcttccaggc tcgtgccact ggcttctggg
13080 agactataag atatgaccta gtgtaaatgg aaataatttt tacctatttg
ggttcaaaga 13140 caccaataaa tctgttcttg gccaccgagg tcagttctat
ttcttcaaat cttgcctaga 13200 gtagtgtttg cacctcatgt tatgggttga
attgtgtccc tccaaaattc atttgttcaa 13260 gtcctaaccc ccagtacctc
agaatttgat ctttcaaaag acaaaattag gattgggtgt 13320 ggtagctcat
gcctgtaatc ccagctactc aggaggctga ggcatgagaa ctgattgaac 13380
ctgggaggtg gaggttgcag taagcccaga tcgcaccact gcactccagc ttgggcaaca
13440 gagcgagaaa aaaaaaacaa aacaaaatta caacaaattt aaatatctta
actgctttta 13500 tttacaattc tagaatcaag caacacctca tcctataaaa
taaaacgggt gttcccaaga 13560 gctgagcaga ggagtttggt ccaatggaga
gaaaaaggct aaggaaagcg gaaacagaaa 13620 acaaaaagtg gattggttgt
ttcagagtta ctttcttgtt aaggctgaag cagaggggat 13680 ttccttatca
tgccggctaa aactggcttc tttggggatt tggctattat ccctcactct 13740
cttcatttct cagatggtca gataaacaaa ttagtttcaa tttggtgaca tggaacctta
13800 gcatgaatga ctccattttg gttgggccta gtgcaggagc tcagtccaag
ccaatggccg 13860 cctataaatt ttatttaaca ggctttattt ggaaataggt
acattgtaga tagaattagg 13920 ttataatgaa gtcaccaggg tgggccctaa
cccaatatga ctggcgtcct tatataaaga 13980 ggaaatttct atgtaaacac
acacacagag gaacatgtga agatgaaggt ggatataagg 14040 gtgttccttc
tacaagccaa ggaatgccaa gaattgtcag tagaccagca gaaagtaggg 14100
gagagcatga aacagtttct tcctcgcagc cctcagaagg aaccaactct gacaatgcct
14160 tgattttgga cttttggcct ccaggcctat gagacaataa atgtccactg
tttgtggtac 14220 tttggtatgg caccctagta aaccaatata cccaggtatt
acagtcagat attacagtcc 14280 atgttagctg gaaacacaag ctaactctga
ggaagccaag tgtgagtctt ccaacactgg 14340 cagtgttggc aaaaggagct
ctgggacagc cttttccagt gagtgacagt gtgggctgtg 14400 cagctagact
gctggtgtgt gagcctccac tggctagctt tgcaatgttg ggaattgtat 14460
ttaacttgtt gcggctgtac aatgggggac aataaataag taccttgtct tagtcctttt
14520 gagctgctat aacaaaatac cacagactgg gtaatttaca aagagcaaaa
attggacagg 14580 cacagtggct catgcctgta atcccagcat tttggggtgc
cgaggcaggc ggttcacgag 14640 gacaggagtt ccagaccagc ctggccaaaa
aactccgcct taaaaaaaaa aaaaaaaaaa 14700 aagcaaaatt tttttcccnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 14760 nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnga 14820
attgtttata tgaatcattg attatgaaat agtaaagctc attctctctt atttattttg
14880 atattttttc tacttaaagt aatacttgta tattgttaga aaaggtaaat
aataataaag 14940 gcaggttata aaaaatcagc agtatcctta cccatcccca
ctttttaatc tcattttcag 15000 aggcagttac ttttaagaac tctgtctctc
tctctctctt tttcttttgg tagagatggg 15060 gtctcactgt gttgcccagg
ccgttcttga actcctagcc tcaaatggtc ctcctgcctg 15120 ggcctcccaa
agtgctggga ttacaggcct gagccactgc acctggccct aaaaattctt 15180
ttaagctttt tcttttgatt cttacctctg cgtttataaa tctgcctaaa ttgctatttc
15240 gtgatttatc aattttagat aatacatatt aacttcttgt tatggtaggt
ggggtattct 15300 tccctttcct tcccctattt ctaaaagcac ttccagtata
ggtatataag aattcttggt 15360 taatatagtg tttagctttt atattattat
gactacataa atattgttca ctgctggtga 15420 gtacttcacc atgtttcccc
ttccctcccc ctagtttgct tagttttcca tggatatatt 15480 attaattttt
accaaatact ttgaacggcc tgtgggattt agtgcctaag aaattgatgc 15540
aaggtgttac tctggctact gctattgcag ttgttttgtg tccctgttcc agaggtttca
15600 tgcctttttc agctttgtca gtaaagtaaa atctcagatc cccaccatgc
ctgacttgac 15660 agtgtaacat cccccatttt gtttgtgctt tctttttgga
actgttacta ttaatatatt 15720 aaaatcttct aaattgttct ttaaattttc
tattttttct cctcctgttt ttcacttatt 15780 tgtcctcttg ttctttatta
tgggagttcc cttaactttt atcttttctc cgttcttttg 15840 ttttaaattt
caggtgtcct ttcttgttct ttatttcctt ttttatgaca tcctactctt 15900
gcttcatgaa gcaatatgaa acggttaaaa gagaatggtt tctgtaccta tcctacctgg
15960 gtttaaaacc tgatgtgcca ctttctagct ctataatctt gggcaagtta
cttaaccttt 16020 ctttgcttta gtttattcat gtaggttagg agttggtaga
catttcatct aaaggaccaa 16080 atcataaata tttcaggctt tatcagccaa
gaggcaaaat gaaggatatt ttaaattatt 16140 taattatttc attatgtaag
tacttacata acaagagaga aaacatttct acaagttttt 16200 tattaataaa
gctcaaaatg cgatactaat aatgattgag aacaattttt gcaataaagg 16260
tttgctaatg agaagaatga atgttttttt ggaggagagg ggataacatt tggcttaatt
16320 ggagtttaaa gttagtgttc tctatcatca aaattgatta tagatgcagc
attaaccacc 16380 tattaatgct gatttgtaat gagatttcat gtatttcatc
tttgaaaatg tcttcttaga 16440 tactgccaaa tactgctaat agtctgtgaa
catatggttt taatagagca tattcattgc 16500 ttggacgaca tttacagaat
tcttttagac tcttttcttg atacttaacg tttagcaaat 16560 cattacactg
cagactaatc acttccaatt gaggattagg tagaagctcc tcattgcaca 16620
gttaaatgat ttttgaaatg tggaatgttc gtttctactt gcattgaggt atgaaaaaat
16680 actgctggaa atatttgatt ttggaaaata tgtctgctgc atatttgtgt
ggcagtagag 16740 atcttcttat tttaattttt gacagcatag gaagtacatg
aagcatcttg acatgacttg 16800 tgacttaggc aatgttagtt gtccttgaaa
tgactgtctc aatataggtt ttgcacgtag 16860 accctgttgt ccttctaact
ttaggctgaa ttcattaaca gatatatcaa gtctgcagca 16920 acaatagtag
ttgagggtca ttcttttcat tcagaaaaat ttgtctcagc ctggagcttg 16980
aaacatttca gtaaaactct gccattgtta agccattgta ttgtttcgtg gcaggacgcg
17040 tcaggatatt tagcttctat ttctgacaaa aatgtcatga gaacaaatga
aatttacctg 17100 tgacattacg gttcaataac acatgataga ttcagatgtt
ttctgcagag tacctgctga 17160 ttgagaatat gattaatagc cataagcttt
aaacacctta catttcacaa ggcttgtaaa 17220 ttttgtccag ctaagccttt
ttctgcttca tacatatttt taccaccatc agttgttaca 17280 catcttagca
gattctactt cagattgtgc tgaattagta tttccttgat tttttggaaa 17340
atattcatag ctgtaattgt ttcatacata ctgtacttcg agccactgtt ttcatggaaa
17400 gagtaggatg ttaaagatat ttattttctc tggacacaat tctttggctg
ctgtaatcaa 17460 acacaattta attaactcac cattggcaaa tactttcctt
gcttgcttaa caaatgagcc 17520 atttggaaat ttacttcggt tgcagcccta
tttccatttt taatttttgg caagacattc 17580 tgctctgagg aggtatatct
tgttttacat ttgcccattt tcctgctcat tgctctcatg 17640 agttgggagt
gaatgctgtg tggcagggca tatcgggata ttgtgatgag tgcttagtct 17700
agtaatactt cctatattgt attttgctgg cacagcttcg tgatgctttt acataataaa
17760 gtactttgac atctaactag atttaaacaa tctacagtcc actgtgactt
acaagtgtga 17820 catcagagta cttctgtttt tttgacgtga tagtcactgg
taaaatagtt atagtatggc 17880 aatactcatg acacttgaaa tgctgttgag
taaaccgtgt cattgagatt tgtggtgcac 17940 tgagagtata aagggatgag
ggcaccaaat atgatctctg tagcaactac ccaagtctgc 18000 tgttgtatca
ggaaaacagc tatagaccat gtgtaaacaa atgagcatgg ctgtattcta 18060
ataagacttt attgacactg aaattttctt ttcatataat ttacacatgt cacaaaatat
18120 tcttttgatt tttttcaacg atttaaannn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn 18180 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn 18240 nnnnnnntga gcttgaagac ccctgagccc
agatgagaac cgcggacctg cctgcatcct 18300 gattttagcc atggtgaaac
cctgagcaga gaatccaact agaccatacc aggacatctg 18360 accccttaaa
ctgggaggta atagatttgg gttgctttaa gcccctacat ttgtggcaat 18420
ttgttatgca tggagaacct ttatgtctag ctaagggatt gcagatacac caatcagcac
18480 tctgtgtcta gctcaaggtt tgtgaacaga ccaatcagca ccctgtgtct
aggctcaggg 18540 tttgaggatg caccaatcgg cactctgtat ctagctaatc
tggtggggac ttggagaatc 18600 tttatgtcta gctaagggat tgtaaataca
ccaatcagca ctctgtgtct agctcaaggt 18660 ttgtaaatgt accaatccac
accctgtgtc tagctcaagg tttgtaaatg caccaatcag 18720 cactctgtat
ctagctcagg gtttgtaaat ataccaatca gtactctgta tctagctaat 18780
ctagggggga cttggagaac ttttgtgtcg agctcaggga ttgtacacgc accaatcagc
18840 accctgtaaa atggaccaat cagcaggatg tgggtggggc cagataaggg
aataaaagca 18900 ggctgcccca accagcagtg gcaaccggct caggtcccct
tccacactgc gggagctttg 18960 ttctttcgct ctttgcaata aatcttgttg
ctgctcactc tttgggtcca cactgccttt 19020 atgagctgta acactcactg
cgaaggtctg cagcttcact cctgaagcca gcgagagcac 19080 gaacccacca
gaaggaagaa actccgaaca catccgaaat cagaaggaca aactccacac 19140
acgccgcctt taagaactgt aacactcacc gtgagggtcc gtggcttcat tcttgaagtc
19200 aatgagacca agaacccacc aattctggac acaatagcac cttctaactg
aaatactgga 19260 aagagagttt tcattgttgt agaatttgct taattattat
cctgatagca gggataatta 19320 ccaacaaaaa ggaagcacga aagttttact
aacaccgagt ttgctagaac ttcttattgg 19380 gtttggtaat atgtcacacc
ctggctatgc aaagaaggtt ataaaggaaa gagattttct 19440 gtggaagtca
tgaagggatt gataactgca ggaaagatct agccaaggtt aacactaaag 19500
ttactccagc cacccaaatc caatgccact tatcctaaaa ggaatgttac ttttatatta
19560 acatttcaac aacatctggt ggaggcaaac cagtgttaca acccatcaga
atagcaacag 19620 aatcaaactc caaatgatgc tgcagacaga accacacacg
gacatgcctt tcttccaagg 19680 acccttagat tgaccccagg aggagcccta
gctgctgatc cccacatgat gccccttttc 19740 agcaggaagt agccagaaag
agtcatcacc caacaccccc taacagcagt tagggttgcc 19800 actccagagc
agggaatgat gatataggag ttaacaagga attacttagg cagatagcaa 19860
gggcatggga gtcctcagta aggctgttct ttttaatgaa aagcagcccc aaatcatttt
19920 ctaacaaaga gcagcctgca agctgggagc ttgcacacga taatgcctgc
agaaactaag 19980 gactagacat tttcaaaatg gcggctccat cttcccttct
ctgccagcca catgtactgt 20040 aaaggagcag acaggatggt gccaatcaac
tggaaagccc atttgcataa gattaggttg 20100 aggcaaccag ccttccccac
acactctgta gacgtcatgc atgatcgaac caatctgtga 20160 gccctatgta
aatcagacac tgccttctcc atataaaaat ctgctgcagg ccgggtgcag 20220
tggctctcgc ctgtaatctc agcactttgg gaggccgagg cgggcagatc acgaggtcag
20280 gagatcaaga ccatcctggc caacatggtg aaaccccgtc tctactaaaa
tacaaaaaaa 20340 aattagccag gtgtggtggc acacgcctgt agtcccagct
actagggaga ctgaggcagg 20400 gggatcacct gaacctggga ggtggaggtt
gtcagtgagc tgagattttg ccactacaat 20460 ccaacctggg caacagggcc
agactccatt tctaaaaaaa aaaaaaatac aaaaattagc 20520 tgggcatggt
ggcaggtacc tgtaatccca gctacttggg aggctgagac aggagaatca 20580
cttgaacctg ggaggcggag gttgcagtga gccaagactg caccattgca ttccagcctg
20640 ggcaataaga gctaaactcc atctcaaaaa aacaaaacaa aaaagaaaaa
gaaagtggcc 20700 acccctgtgg aaaaggactc tggagtgggg agggtggtag
agcagttttt tatattaagt 20760 ttgtcatatt agttgacttt tcaaaatcac
atccatatac tactttgatt aaaaataaaa 20820 tattttctgg ccaggcacag
tggatcacgc ctgtaatcac agcaactcgg gaggctgagg 20880 caggaggatc
acttgaggac aggggttaga taccagcctg ggcaatatag caataccctg 20940
tctctaaaaa aaatttttta attagccagg tgtggtggtg catggagatt tcaacaacaa
21000 caacaaaaaa agcacaaccc ataaaagaaa aaaatttata aactgagctt
catcaaatta 21060 aaaacttttg ggccaggtgt ggtagctcat gcctataatc
ccagcacttt aggaagccaa 21120 ggcaggcgga tcacttgagg tcaggagttc
aagaccaggc tggccaacgt ggtaaaacct 21180 catctctact aaaaatacaa
aaattagcac agcatggtgg tgtgcgccta taatcccagc 21240 ttctagggag
actaaggcac gagaatcact tgaacccagg aggcagaggt ttcagtgagc 21300
caagatcatg ccactgcact tcagtctggg gaacagacca tgactccatc tcaaaaaaaa
21360 aaaaaaaaaa aagaagtgaa atgaaggaca gcaatgtata tgtgaactga
aaatgcaaca 21420 gacaggcaga aagaattagg aatgcttgtt attataaggt
attgtgcaaa ctgtgaagtg 21480 gtgatgtnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 21540 nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnntgt gtgtgtgtgg 21600 gtattttttt
ttttttttct ttttttgaga caaagtgtct ctgtgtcatc caggctggag 21660
agcagtggca tgaacacggc tcactgcagc ctcaacctcc tgggctctag tgatcctctt
21720 gtcccagcca cttatgtagc tgggaccaca ggagtatgcc accatgccca
gctaattttt 21780 tgatcttgta gagacaaggt ctcactttgt tgtgcaagtt
ggtttcaaac tcctgggctc 21840 aagctatcct cttgcctccc aaagtgctgg
gattacaggc gtgagccacc acatctatcc 21900 cctttcagat atcttaatct
tggtaaattc tttcagttac taatctgtga tgaactaatt 21960 tttttcttca
catatatcaa cagttgagga gctcaagctt gggaaaatgg tgtgcattcc 22020
ttgtatcgtc attccagttc tgctctggat ctacaaaaaa ttcctggagc catatatata
22080 ccctctggtt tcccccttcg ttagtcgtat atggcctaag aaagcaatac
aagaatccaa 22140 tgatacaaac aaaggcaaag taaactttaa ggtaagaaca
ttcacatgcc ttgaataaga 22200 gcagtgaaag ggggtggtac ttgggtgaaa
cactagattt tggaaggaca agttttagaa 22260 ccagaagctt caatagtttg
tgtaacattt ggcttaaatt aaagttttaa agtaggcctc 22320 tgattaatgc
atttgtcctt tggccaaaat gataaccata ttttctgact ggtaagtgca 22380
atggtaaata gctaatggat gaggagagat tatgctgata caaaccagtt tcactgattg
22440 atgactttga taagagattt aattagaagg atcatagaga tttaaaaaaa
aaacaatttt 22500 tttaaaaatg agtggacaac tctgttgtct ttagaattgg
tgctttttta gattcagctt 22560 tgtactcagc tgcactaatt tagccatccg
gcccgtttct ggaagcaaaa tgttttcact 22620 ctggagcttg tctgttttta
aagagaatgt ttcttgagct gggcgcggta gctcacgcct 22680 gtaatcccag
cacttgggga ggtcaagatg ggttgatcac ctgaggtcag gagtttgaga 22740
ccagcctgac caacatggtg aaacctggta attcccatat tagcccggca ctggtggggc
22800 aagcccgtag tccccactac taggggagct gagatgagag gattgcttga
acccgggggg 22860 caaaaggttg cagtgagctg aggagaaact tccctgcaat
cccccctggg ggacacgagc 22920 cagaccccgt ttggaaaaaa aaaaaaaagt
aggaatcatt cttcaggcag cacatagggt 22980 ttagcccttg ggctgtaatt
tgccaattta tgatttaggc aatgagaaaa aaaagtacca 23040 cgccatagtt
tgtggtgagt gtaaaatcag ttagtatatg tgaaacagtt aagatggtga 23100
ctggggacat agtaggtgct aaatacatgt ttggtattat tgttactgtt ttcattatta
23160 tctatctaaa gatattttag tttttaattt tttcttagaa tcatctgttt
tctatgattc 23220 ctttctttag tttgtttcag tttctttttt ttatttttga
gacaggatct ccctctgttg 23280 cccaggctgg agtgtggtgg cacgatcaca
gctcattgca gccttgacct ctcaggctca 23340 ggcaatcctc tcacctcagc
ctcccaagta gcaggaacta taggcgtgca ccaccatgtc 23400 tggctaattt
gtttattttt ttgtagaggc attaaaaatg tctctgtgtt gcccaggttg 23460
atctccaagt cctgggctca agtgattctt ttgtcttggc ttcccaaagc gctgggattc
23520 taggagtcag tcaccatgcc cgggctgctt tggtttctat atttcatgct
ggagacttta 23580 ctcacaagtc taatcatttt tgactgtcca ttcttattta
aagttgagac tacccaaaaa 23640 ctgattggaa gctctttgtg taagtagatt
ttgttgagtg gtgggcattg ctgtgaggtg 23700 acgatctatt ttttaaattg
gcctggcagt tcctaaattt ctgtatcttt tccctaggtt 23760 cctattcagt
ttctcttgag aggaatcctt cagtctcctg ccttggaggc agggaaactc 23820
actgtggagc tgtagcaagt tgactttatc ttcattctct tgttttcttc attttccacc
23880 ttattaccct ccccaacctt ggcattggtc tctctagttg tatttctctg
ggaagcacgc 23940 ataatagtct cttcctgggg agagagaccc ccaggcttta
gtcctgcacc ttgccccgtc 24000 ttccccagtg ccctgtctct cgctctttag
ccttcccacg gctccatggg gtgaattgcc 24060 ttccttcttg ttggtgtccc
ccttggcagg aactcctttt ggggcttcct caggtcggct 24120 ggttcaggta
cactcctctg tcaccttccc atcttccaca cttcccttga tctgatcttt 24180
gtgggtttat atctttcttt ccattgcttt cgtttcattg ggcggggaat acccaactgt
24240 acttaatata gcacttggag cctagttgcc tttcagagaa tgttctatta
cttgtggact 24300 catggcacct gtggcattta ctctgtcctt tggctggtga
ttattgccca ttatttctct 24360 gatctcctgt ttcagctttc tccttaaagt
ctctgaggta caagtggggc aatatgtgtg 24420 nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 24480 nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ggcatcccgg caagtcatgc 24540
aaaaggcaaa ggctggcagg ttgcgctggc tcttgccagc cctcccaccc ccacctcctt
24600 cccttatacg gctccctaag ccagtgctgg tgctgtccag ccagccgagc
ggcctggcag 24660 cagctctgaa accttgtcct catgcctgaa cctggaggtt
tgagaggcaa gaaggctgtc 24720 agagctgtgt ctcctggagc tgccttttaa
tcttggtgta ggtgtcttga aagttcaggt 24780 ggcagggtag ctggctttgg
tttgattcgt gcttgcaggg agcgtctggt gggtcgcttg 24840 tgcttagaag
ctgccgggcc tattccccca ggttgccagc cttttcctct tcaacactct 24900
tgtgctcccc cgactcttcc tcttcccact cctcctccct ttcctcctcc tggcttttag
24960 cttctcttcc tcttgggttc tgtatggcag cctttgccag tggaggcagc
ttgccctggg 25020 ggagccagag tcagtcagct ctgggggagt cagaatcaga
gtgagaacta agtcagctga 25080 taagcagtgg agggctgggg agcctctaaa
ctgaacccca tcatctcatc ttctagtctg 25140 ctgaggttgt gccaaatggt
ctgtgtgggc ttgtgtatgt gtgggagggt tactgtgaat 25200 gaatggaaag
ccttgcttta ctcaacatgt ttccaactct ggtgctaact agaagcattg 25260
cctagggcag gtctcatctc tggctcctca cctgtaaaat gctaaagttc cttctaactt
25320 ctgtgttctg ggcctctgag tatgtgtgag tcatttcctt cattgcaaaa
agtatttact 25380 gcatacctac ttagtgtcag acactattct gggagcaggg
gagagagcag tggacaaaat 25440 agatggcaat ctgtgccctt gtgacactta
catttcagtg gtgggaagac agacagtgca 25500 ctgattaaag tatcagtggt
gctcagtatt atggagaaaa atcaagcaga ggaggaaggt 25560 ggggcatgtt
ggtgggggaa ggtggtgcga ttttatgatg tggtcaggga aggcctttct 25620
ggagaagttg accattgagc aaagagctga agggggtgag agaaggagcc atgaggacat
25680 ctgggtgagg aacaatcaga aagtcccaga ggctgaagtg acccaggcca
aaagtagtag 25740 gaatgtacct agagaacttt ggggtcagag caggtcagac
tctaagagga agagtctttg 25800 tccatatgtg ggtttatccg cagatctgtc
tcaggaatcc aggagacttc ttttctccta 25860 ggtttcccca tctggcctct
gcatgagtgg ctatctgggt agaaggtggg gagttgtcga 25920 actcattatg
tccgtggttc aaatttctgc tggttggggc ttttgttcat tactttcatg 25980
acggttaacc tgacttccgc tcatgtgcat tcagcagcat tttctggaac cttatccctc
26040 ttacatctgc tgcattcttc cccctctctc cctcctttcc cctccgccct
ctccaccact 26100 atatctcttt ccttttggta tcttcttcct tttgcttctt
aactctgaga taaattaact 26160 ccaagatggt catttggcat ctttccctgc
tgggtgatag gagagtttga tactctcact 26220 ttctagccag ttatccagtg
atgcatccca ggatggctga aagagtgctg ggtggggtcc 26280 atttatgact
ttctgaaacg gtgtcatgat gacagcacct acttagtgtt aagccacagt 26340
ggccatcagt gacatgagct gcactttggg agcagggccg tctcctaggt ggcactgtgc
26400 atgagcagtg aagctggaag gggggatttt tgttgctttt aggagtttct
ccatggcttt 26460 agtcatttac ttaacaaacc agatgaatgc ctggcacatg
ccatcactag aaagggcact 26520 gaggatgcct gagtttccct agatgggaac
actaggggaa gcctattttc cagcaggtca 26580 acagcctctt gcctccaatt
ccaaaatcca caaactctca aaattggaaa atgtgtttgg 26640 taacttgttt
ggcagcaaga cctggcctta cctgatctga acttatttgg cagcaaaaac 26700
ctggcctgag ataacaggag gctattggtt atctttatat ttgccctcaa atgtgagtgg
26760 ttatgtattc tctgcagaaa tattaggatg tttgatccag ggggaatagc
ccaggcccca 26820 ctggcagcat tatataatat atggtgtatg ctccatgatg
cctttctaaa atctgaaaac 26880 ttctaaattc tgaaactcac ctggtcccaa
gcatttcaga aaaagaactg agaacctgta 26940 ctctaaaagt aggaaggaag
tagaactcct tttgatagga aagaagaggg aaatgcaaga 27000 gagagatcta
tttatttcag agtgacagta attaatacta gtgactaatt aatactcttt 27060
aagtataaat gagatgtcct tttttataaa atgttcacag tttttctggg aggtgaaaag
27120 ggaacattca gcagatgtaa aaaccgaaac ccagatggct taagcaaatt
gctcacgatt 27180 gaactagaat cagaccccag gtctctcact ccgcaagtct
gctagatgca cccacgctct 27240 gttctgtctc cccagataag ctccacaaac
ccaaagctac acagactgag gtcaaaccat 27300 ctgtgaggtt taacctccgc
acctccaagg acccagagca tgaaggatgc tacctctccg 27360 tcggccacag
ccagccctta gaagactgca gtttcaacat gacagctaaa acctttttca 27420
tcattcacgg atggacggtg agcccgggga gggagctctg cggctttata taagatttga
27480 ttccctttgt tttggtcaat tagaaagaat tctggtgttt ccagattcca
aaccctcttc 27540 ccccctttcc ttgtgggctg cttgtatttc agacagctgt
gaagaatgta acgggcattc 27600 actaaggggc aatctggact ccagcagggt
ggtattaatg atggcataca acgggctttc 27660 agaaagtggc tctcctgagg
gcagcagccc agctccactg gctcttaagg acccctctaa 27720 ttacacttaa
ttacgctggt caaccactgc ctggaggggg ctgtcctgcc gtgagagctg 27780
agcttaacta aagcaacttg actggctctg agaacctatg agtagccagc tggcctggat
27840 tgctgactgc ccttggcata gtgccctcct gtttgcatag agatagcccc
gtttaaaggc 27900 actggggctc tttatgtgcc ctagctgagc aattcacatt
gaaaagccca tgacaaactt 27960 caacaaaaaa gggctttagt gctcagcttc
agaagctttt gaccagccag gaatttattc 28020 attcatataa tgacagtctg
tagggaaatg gcactattaa gtgagcagat ttctgcctgg 28080 gctaattgga
aggggacagt cctcctctta atgatgagaa attcatatct gttacatgct 28140
tttggggtct ttaaatctgt catccatggt tgaggtcagg ggcaggagag ggtaggtgcc
28200 tgcctaccta gttgaatgaa gagatgatta agagcctgtc taaccctgct
catcacacaa 28260 cctacaatca gaatcatatg tgtgaatctt tttaaggccc
cctgtcaaaa tgcaaataca 28320 agctgcctgc gacttacaag taggttgcat
tccagaaagt tcttttgtaa tctgtttgga 28380 acttggaaca gcagtttccc
acagaagcaa gattgtaaat ggtgtttggg ttcccaggct 28440 aggcacagaa
aatctatcta tttgataatg tgcttgtgga taggtttaca actggaccta 28500
gtcaccattt ataactttgt ttctgtggaa aaatacattc tgagttgtaa tttgggattc
28560 cggggacaga ttttccctac tctggggtca agagggatgg cagagatggg
ttgtgggaag 28620 gggtcatttg ttaactctgc attcacctag gagacagcat
ctccctgcgt ctctaagaga 28680 gaagcaattt tccagggcaa ccctccctag
ctgcctttga aggatggacc aggccacttg 28740 cctgcctgta acagggactc
agaccagcct catgccagta tcacccttaa cacgtatctc 28800 atagtggccc
taacagacag tggggcaaca gtataggaca ttagctagga aagttttgat 28860
gggaaatact ggggatgtaa ggagcaatgg aagacaaata cctgcgtagt gattctgcct
28920 gtgctggtcc tgctcatgtg caaatgtttg gtccctgagc agccaatgtg
cagattctaa 28980 aattgtctgg gggcactggg catggtggct cacgcctata
atcccagcac tctggaaggc 29040 ctaggtggga agatcgcttg agcccaggag
ttcaagacca gcctgggcaa catagtgaga 29100 ccctgttgct gcaaaaagtt
taaaaattac ccaggcatgg tggcatatgc ctgtaaccca 29160 gtcactctgg
aggctgaggt gggaggatca cctcagctca ggagttggag gctatcatga 29220
gctgagattg ttgtcagtgc actccagcct gggcaacaga gtgagaacct gagtcaaaaa
29280 aaaaaaatta attgggaaga gggtcatata gaaaggaatt ccatattttt
taggatttct 29340 gaaaccaaga ataaaaaaca acttccactt ttctctgcag
atgagcggta tctttgaaaa 29400 ctggctgcac aaactcgtgt cagccctgca
cacaagagag aaagacgcca atgtagttgt 29460 ggttgactgg ctccccctgg
cccaccagct ttacacggat gcggtcaata ataccagggt 29520 ggtgggacac
agcattgcca ggatgctcga ctggctgcag gtactggggg atgagaggga 29580
gtctcctgtc accagcagga tctcaaaccc aatcttctta agaaatgcag gtcatgcatc
29640 tgttgccatg aacttctgga gtctgataaa aatctttgag attaaaagtt
ttattgaatt 29700 aagtattgtt tggaatactt gaaagctggg actttttgag
agccttttaa ttattgatag 29760 atctctggat ttttcctgtt acttaatttg
ctgaaaattg gccttatggg ttgtttcttc 29820 ctgatcttag aaacagatgc
ccttaggttg gttggggatg gccaggaacc aggccaggct 29880 tgtgatctga
aattcctaca aagactgctc ttgtctctga agcatggctg tgctgagggt 29940
ggggaggggg ttatttcaaa aatgcagcct aatatctctt ttctttgaga tggagtcttg
30000 ttttgttgcc caggctggag tacagtggtg tgatcttggt tcactgcaac
ctccacctcc 30060 caggttcaag cgattctcct gcctcagcct cccgagtaac
tgaaactaca ggcctgtgtc 30120 accatgccca gctaattttt ttgtattttt
agtagagatg ggatttcgct gtgttagcca 30180 ggatggtctt gatctcctga
cctcatgatc tgcctgccta ggcctcccaa agtactggga 30240 ttacaggcat
gagccaccgt gcccagcctg cctgatacct cttttataat atgaagtgtg 30300
gaaaacagat cttgaagtct tatatttact tttttttttg agacagagtc tcgctgtcac
30360 ccaggctgga gtgcagtgcc atgatcttgg ctcactgcaa cctctacctc
ctgggttcaa 30420 gcaattctcc tgccttagac tcccaagtag ctggttttac
aggtgtgagc caccatgccc 30480 aattaatttt tgtattttta gtagagatgg
ggtttcacca tgttggccag actagtttct 30540 aactcctgac ctcaggtgat
ctgcctgcct cggcctccca aagtgctggg attagagacg 30600 tgagccaccg
cacccagcct atttactttt aataggttaa taatctgcct gagatcagtg 30660
gatttagctg ggagaaggca gggcagggta cactgtcaaa gcggcaccat tatctgggca
30720 attccggcct ggccttcctt gttcccatgg aatgggatga attctggcag
aattctggtc 30780 aggattctcg agcagtccct ctgtcctcta cctaagctct
tctatagagt ttggtttccg 30840 agccatgggg ttacctcctt accccccaga
tgagtgctct gacaggggac aatgcgtcaa 30900 gtctggggtc ccacatgggc
ttgtgaggag gaggttggca gctcctgggg ctgggtggag 30960 gtcaggcctt
agagggcagg cagagggcat tctgctgagg gctgtggttg gcactgcagt 31020
ctccagtgag tacggcagct ttgacctcct caccatcacc ctcccctctc ttagatactg
31080 ccagaaagaa caggaaatgt gtagggaaca gccacatatg cagcctccag
tcataccctc 31140 caccctgtcc ccacacttgg catttgcagt gccaccaagt
ccttttggcc tcccctaagc 31200 tggctgtgac ccacacatgt agcatcacca
gcaaagccag tggggccctg gggagtctct 31260 gtgcccacgg cccctgcatc
tcctcctgct ccgtgactga gttgttgaac tgctggtgat 31320 tctgggggct
ctggaccctg ctcttctgct cacatacttt ggtgactttc tataggagaa 31380
ggacgatttt tctctcggga atgtccactt gatcggctac agcctcggag cgcacgtggc
31440 cgggtatgca ggcaacttcg tgaaaggaac ggtgggccga atcacaggtg
agctccactt 31500 ccatcactaa agggctccct cagctgcgct aagccggaat
gctccccaat gaggcagcag 31560 agtgagtcat agaaagttag ctttggaagg
aacctggaaa gcatctaatt caaaacttcc 31620 caagcgtttt tagtcacaag
gaactttttt ttttttttcc aaattgaact cgcataggcc 31680 cgcagtatat
gagacacaga aaggggggtg ctgtgggtga agtggggtgg gtatatggcg 31740
gcttgtgtta gccttgccag tgtgggcgtt ccccttccct ataggcatct cagagtctca
31800 gagcaccagg gaacacagtt tgaaaaccat aggcctggtc caataggtga
ggaaacaaac 31860 acggagaggt gagacaactt gcccaggggc aaacagctaa
taactcaaga gcggaagctg 31920 gatagagccc tggccccaaa gcttttgggt
gttcccttca ggtctccacc caaggactca 31980 ggggaaaaga atgaatagta
gattttagtt tgaattctgc ctctgatttc tatcttgtct 32040 cccaatagcc
tctttcccat gttaaggtag catatttatg aatgagagct accaatttgg 32100
aaagggtggt tcaactttgt aataaaagga acctttctga tattggtccc cagggggtca
32160 acagaaaatt gaattttcca tgttgaaaac tgcatcttag tgagctttta
acatgagagt 32220 ttggattaaa tcatttaatg attgtgaaaa gtgtaaaagg
ttttctttct catttttggg 32280 cccctcaagt atatacacag agattcctct
atgctacaat taatggtaaa tttgttgccc 32340 tgaacttcta tccttcttcc
agcattattt tatttaaaat tacccctagc ttccccctta 32400 ctcccaagat
tctaagggtg atcacctaga aggatagatc tgaacaattc ctttccctgc 32460
agtgttttca ttttaaaaca aaactcaggc tgggtgtggt ggctcacacc tataatccca
32520 gcactttggg aggccgaggt gggtggatca cgaggtcagg agttcaagac
cagcctggcc 32580 aacatgatga aacactgtct ctactaaaaa tacaaaaatt
agccagctgt ggtggcgggt 32640 gcctgtaatc ccagctactt gggaggctga
ggcaggagaa tcgcttgaac caaggaggta 32700 gaggttgcag tgagccgaga
ttgtgccact gcactccagc ctgggtgaca gagcaagact 32760 ccgtctcaaa
aaacaaaaca aaactcaggt agaagagagt ccttagctaa ataacgattt 32820
ggtaaaggta gaatttcaga tttcagtgac aagctgatat ggtagaattt taaaaagaat
32880 atttgtgaag ttttcctggc tctcctgaat cctgtccctg ggcttgagtc
tagtatgtgc 32940 gtgcacacac atgagcatgc atgcacacac atgcctgttg
atccaatgac ttgattcatc 33000 ccagcttgag agctttattt ttgatttcca
agactgtggg gcttgagctg cccaaagcgg 33060 gctatgattg tgtggccacc
catgactgct cattaacccc ttgctggtgc aaagcagttt 33120 gactggaagc
cactcgggtt ccattgtctg agcgcctctt cctagcccct gaatgagagg 33180
tgtgatgttt cagatccagg cacctgagtt caaattgtag cacacaccac agtccaggcc
33240 cagaatgtca gtaacgatga caaactgcac atcttgcctt tctctatttc
taaatctgaa 33300 atgagatggg gctagggagg gaactttcca gttctttccc
cctgcctgtt tgagtggcat 33360 ctgctggggt gagggctttt ctcctgaggg
tggcaggaga gccaggcaga atgctaatta 33420 gtgctctggg atgtttgcat
ggagcatgat gcccacatgc cctgagcatg gtcccttccc 33480 tctggccttt
ctctgtagag aaggggcctg gcctctgtcc agttgccaag cagcacccct 33540
gacacacgct gttgtgtatg tctgatgggg gaggctgcgt cctctccttt ccccttggta
33600 gacttctcat ggacctgtgg acaaggtgat cgcaactggt aagaggacag
attgagactt 33660 gcatggggtc ctgcgtccag tgatgccact atgctaaggc
caccaggcag tccttagcct 33720 gggccttgca agggtatatc tgaaccccaa
tcttgcttgg accagagggt gtggatgggg 33780 gtttgctaga gttttacttt
cttaggcttc tgagagaagc ctgtgatact aggaaagagg 33840 tcatatattt
atagttgaac ctgtgccttg tttgctataa tcaggtaagc aagcagatga 33900
atttattcaa gaaatgtgtc catatgtgca ggctagatgc tagctaatgt caaatacctc
33960 atgtgtggcc gggcgtggcc gggcgcagtg gctcacgcct gtaaccccag
cactttggga 34020 ggccgaggtg ggtggatcac ctgaggtcag gagttcaaga
ccagcctggc caacatgatg 34080 aaaccccatg tctactaaaa gtacaaaaat
tagccgggca tggtggtggg tgcctgtaat 34140 cccagctact caggaggctg
aagcaggaga atctcttgaa cccaggatgc ggaggttgca 34200 gtgggctgag
attgcgccac tgcactccag gctgggtgac aagagtgaga ctctgtctca 34260
aaaataaaaa ataaaaaata aaaaacaaac aaacaaaaaa cacctcatat atgacagcta
34320 ctctatgcta tctctgaacc acatagcaac cctgaacatt ctacggaggg
ggaaactagg 34380 actcagtgat taagtaaagg gcccaatatc ctgggcccta
taagtagcag agctgggact 34440 caaacccatg ctgtcagatt ccagatccca
tgcacctcac tgctgtgcca tgctgcctct 34500 cttctgtgga cagagataaa
gtagccaggc atggtagtgc atgcctgtaa tcctagctac 34560 tcgggatgct
gaggtgggag aatcacctga gcccaggagg tggaggttgc agagagccga 34620
gactgggcca ctgcactcca gcctgggcaa cagagtgaga ccctgtctta aaaaaaaaaa
34680 aaaaaaaaaa agtagccgtt gaactacagc aggccctgcc ctgccgggcc
agaatgcaca 34740 gccctggaag ttttacatgt gtgcatgtgt gtgtgctcca
tttgctggac aaagcaactt 34800 tggaggagtc tatgactgaa tggaagaagc
ggcggaggtt ctctatctcc tctttattta 34860 aggaggcagt tctccctgtc
attcatccct agttaaaaaa gttaaatgtg ccactgtacc 34920 cctgaatctg
tgggccacag atatgtgtca gggacagtca gagcagggca ggcaggctct 34980
ggctgggtag gtgaaggccc agccttgcct gccagccagc ctgtgaaacc ccatcagctg
35040 cctgcattcc tccagcacag cctggtttcc atggcactga ccgtctggtg
gggacctttg 35100 ttcacaccaa gtaaagagcc tctctcttgt attgattgca
aagcagaatg ttgctctctt 35160 tctctttcct ccaggggaca tggtgagagg
cagggagagg ccgctgtgtc agtactgcgg 35220 tccttgcggc ctctgaaatg
ggttgtcgtg ggctgttctg ggagcacact gcttttgtgc 35280 catctttctt
ttgggtcctg ggctagggat aaactctcaa gcagcctggg ctccctttct 35340
gtcttggttg cacataaagt tatctaaatt tggctgggtg cagtggctta tgcctgtaat
35400 cccagctact caggaggctg aggcaggaga atcgcttgaa cccaggaggc
ggaggctgca 35460 gtgagccgag atcgtgccac tgcactccag cctgggtgac
agagcaagat tccaactcaa 35520 aaaaaaaaaa gaaaaaaaag ttatctaaat
ttttggaaac tatttagcgt ttcagcctct 35580 accagttctc atatgagtaa
tgagttctgc aagttgaccg tccactctag acggtagctc 35640 tgcctcttgt
ttatcctgaa actaccatct caagtctcct gataggctcc ctggttctaa 35700
tgtgctgtgg tctggtgaac acggtcgtta accatgtcct cctttcagga ctcttgttgg
35760 tcacatctcc tcccagcctt ggtgtttcga ggccaggttt tctcagccta
ggcaatattg 35820 acatttgggg ccaggtaagg ttttggtgtg gggtgtgtgt
gtgttgggat tgacttgtgc 35880 actgtagaat gtttagctgt attcctggcc
tggccctgct agatgctagc aactctctcc 35940 atcagaatgg gggcaataaa
aaggtctcca ggaatttcca gatgtcccct ggggggcaaa 36000 gccacttgta
gtggtgaacc actgttccag cggcccttcc ttcctggcac atttcatccc 36060
ttaactttct ccaggtcctt cctgtgtgtc tgtggggcaa agagctgttc tggttgggat
36120 aaatctggtt cccataatca cttgggcttg gtaatagtag ctaatactga
caggcactca 36180 gtctcttaag atctcacgtg gactttgaat taaggtataa
attcaggttc cattttataa 36240 atgataatga aacacaggga agtttttcaa
tatttggccc acagaatacc tacttttagg 36300 atcatccggg gaataaatat
ctatttctat gtgccataat tcatatctac ccactaggag 36360 ttcaggcact
tgggaatctg cattttatac tttgcaagtt ctcttttgga atggttttac 36420
attaatgcag ttttcaaatc aaaagatggt gaaagtctct cttactgctc tgctacctgt
36480 ccgtttccct tacccactct ctcccccaac gcacacgcat acaggtaact
agttgcttgt 36540 gtgtccttcc agattttttt gtagctgtat ggtggaattt
aaatttaaca agctcccaat 36600 ttcaaatatg agaaccagtg ctctcaacag
tgctgcttgc ctgctcaaca caaaatgttt 36660 ggaggcggaa aggttttctc
acggtggctg caaaatagag gaattctgga ggcctgatgt 36720 atggattctc
agtgtattgg gtgtcctctt ctctctcacc attccacccc tgggcctgat 36780
taaaggaaga agaataaatt cagatacaaa tagctccgtt tggggagact ggattctcct
36840 tccagaagga tgtaggcagc ttagttattc tgtaaaaatt ctgctacaat
taaggacatg 36900 aaagatgctc agtggcagaa tgaatgggac aaatggctta
gtttcaggca gtctgagttc 36960 tttctagaac tgcttcagtt ttaacaggag
cagttccttg gagctgtgtg gcagcgaaac 37020 ttgtggctag ttgacggggt
ttggctgagg tgacgggata catgaaggct tcagaagaaa 37080 gtataaattc
cataacagta ggatttaatt tctgcaatga tgtcttgggg tcaactgcat 37140
atggaaatgg gtttcttatt ttcttccatg ctttccatgt cttgattctc ccagctggtc
37200 tcagaagtca tcttcattct gcacactcag acttaacttg taatcaggac
tcactgacca 37260 ggtgcacctg acaccacagc tgttttgggg cctccttctg
ctgcaggttt ggatcctgcc 37320 gggcccatgt ttgaaggggc cgacatccac
aagaggctct ctccggacga tgcagatttt 37380 gtggatgtcc tccacaccta
cacgcgttcc ttcggcttga gcattggtat tcagatgcct 37440 gtgggccaca
ttgacatcta ccccaatggg ggtgacttcc agccaggctg tggactcaac 37500
gatgtcttgg gatcaattgc atatggaagt gagttccctc ttttctgctt tgtgtttgac
37560 tcagtttatt ccatctcctt ctaaatcagc cagagccttt agcactgcag
gcactattta 37620 ttcattattc tcacctccca ccacagaggc ctccaatgct
gtatttaata tttctcattg 37680 ttccccaaga ctaaccaacc cagtggttcc
tgctttgctt tctcacgctt taaggtcaca 37740 gttgttattg attaatttct
tttcttttct ttttctttct tttttttttt ttggaaaggg 37800 agtttggcct
cttgttgccc aggtttagat tgcaagggtg caatcttggc tcaccacaac 37860
ttccgtctcc caggttcaaa cgattctcct gcctcagcct cctgagtagc tgggattata
37920 ggcacatgct accataccca gctaattttt gtatttttag tagggacggg
gtttcaccat 37980 gtcagccagg atggtctcga tcttctgacc tcgtgatctg
cctgcctcag cctcccaaag 38040 tgctgggatt acaggcataa gccaccgcac
ccggcttgtt atgataattt ctaaaatgtt 38100 ttttcatttt agggtgcaga
catgaatgga ttaccaacaa aaggaccaac agaaatctgt 38160 gataaaaaga
aagactaaag aaattttcct aaaggacccc atcatttaaa aaatggacct 38220
gataatatga agcatcttcc ttgtaattgt ctctgacctt tttatctgag accggaattc
38280 aggataggag tctagatatt tacctgatac taatcaggaa atatatgata
tccgtattta 38340 aaatgtagtt agttatattt aatgacctca ttcctaagtt
cctttttcgt taatgtagct 38400 ttcatttctg ttattgctgt ttgaataata
tgattaaata gaaggtttgt gccagtagac 38460 attatgttac taaatcagca
ctttaaaatc tttggttctc taattcatat gaatttgctg 38520 tttgctctaa
tttctttggg ctcttctaat ttgagtggag tacaattttg ttgtgaaaca 38580
gtccagtgaa actgtgcagg gaaatgaagg tagaattttg ggaggtaata atgatgtgaa
38640 acataaagat ttaataatta ctgtccaaca cagtggagca gcttgtccac
aaatatagta 38700 attactattt attgctctaa ggaagattaa aaaaagatag
ggaaaagggg gaaacttctt 38760 tgaaaaatga aacatctgtt acattaatgt
ctaattataa aattttaatc cttactgcat 38820 ttcttctgtt cctacaaatg
tattaaacat tcagtttaac tggtagttca ttttctttta 38880 aagtctattg
aaatattcaa aagggaaatt tttcaccacg tcagaaggca gaatttggat 38940
gttatggcat ctgtgtagtg gtgggacaac aattactatt gttgcgtaac aagacactcc
39000 aaaatttagt ggttttcagc agcagtgact cgactgggca gttctttgct
gttctgggct 39060 cactcatatg gctggctggg cctgggtctg gacctgggcc
gctatgtgat ttttatcttg 39120 ggctttgaaa attcagtgta gggacctata
aatattcaaa gatgatgaga tgcatcctta 39180 tatatttttt gtattcactc
tgaagctggg aaagattaaa aggaactcct gcccttgggt 39240 ccctaatgaa
gtctgggtcc taactcgctc tattaagttc tgtggctggt caagtcactg 39300
atctaccttg ggctttattt gatataaatc atataaatca gcaggtctca gcttttctgt
39360 ccaaagccac ctgagggata agataaattc tcattagcaa ataaactttt
ttaaggtata 39420 aatactatta taaaaataac agatatttac agtacaacaa
tgcaagagga tcctaaatga 39480 aaagcgaatg ttttttctca actctcattc
ccttattcca gctccacaga ggtaaccaat 39540 tgtttttttt ttgttgttgt
tgtatggttt gtttttgtta gacagtagtc ttttcctgaa 39600 cagtgctgct
ccttgtggag caaggctaat tcataggcag tgcatccaga gtctgcccca 39660
gttgattttg tgtgtaacct tctagcaact ttttgaaaat taatttgttc ttaaatatgc
39720 acatcatttt tatttattta tgtttttgag acagggtctc actctgtcac
tcaagctgga 39780 gtgcagcagc atgatcacgg ctctctatgg cctcgacctg
cagtcctgaa gtgatcctct 39840 caccttagcc tctcaagtag ctgggactac
aggtgcacac caccatgccc agctaatgtt 39900 ttttgtaatt ttttttatag
agacagggtt tcgtcatgtt gcctgggctg atctcgatct 39960 cctgggctca
agcgatcctc cactttggct tcccaaagtg ctgggattac aggcatgagc 40020
tactactgca cctggcccac acatcatctt ttaaaaatta agtaatattg caacgtttct
40080 aattgtccct acttctttgc tcctcaaagg ttttacctac tgagctgtgg
gctttttaaa 40140 tttatctcca tatttataaa taaattataa aaatataaaa
atataaacat tttatttttt 40200 gagacagggt ctcactgtca cccaggtgct
ggagtgcagc ggcatcatca tagctcacta 40260 cagcctccaa ctcctgggct
caagtgatcc tcccacctca gcctcctgaa ttgctaggac 40320 tacaggtgtg
tgccaccacg cctggctaat tttttgtaga gacggggtct tgctctgttg 40380
cccaagcgag tctcaaactc ctggcctcaa agtgatcctc ttgcctcagc ctcccaaagt
40440 gtcgggatta caggcatgag ccactgcctg gctatactgt tatattttga
gccatcaact 40500 tgagacattg tttcccataa tggttgagat gccgctatct
tacactgcct ctgctcctcc 40560 cacacatcct cccaagtgct tttgtaaatt
ttgcttacat catcagtgtt catagcatga 40620 gtgtgccagg tgtctttcat
ttgcccctcc caagtctctg ctcccctcat cctgctttca 40680 gcccaaggaa
gctgtataga catcaacaga cttcccatgt ctctgggttc tgctgggttt 40740
ggccaatagc gatccatagc aggagatggc tggagggagg agaatgaagg cagagtgttt
40800 attcccttgg ccctctctct gcaaggtcac ctcaggccaa ctgttcctca
gccagaagtc 40860 actgtgcctc aaggaacact ccaggcagcc aactccacct
gacttctttt atttttccta 40920 acctgtcctt caccctgccc ttttgggccc
aggggtggtg gtatttctgt tactggctct 40980 gggctactgc ttcctctcaa
gagtgctatc tggcttgctg ggacactgcc tgggagaata 41040 ctattgctca
ctgcacaggt taatgcactg tgattgcctc ccttttaata tacaggtggt 41100
gtcttcctgg agtgaccagt ttaccttctc cccatacacc tctcctgcct agttgttgcc
41160 tagacctggt gcacactgca gtcctcggga ctttctgttg ccaccctcct
gtattggacg 41220 tcttgtttct ggatttccta tcctcttcct tcttggttta
tccctcattt tttctgtagc 41280 acagcagttt tctaattcaa tacttttagg
aggttgagta tggataattt tggaaagtgt 41340 ccccgggatg attccaattt
atttaagcct gttttccaga gagctgcggg tctcctaagg 41400 cctttctcat
ttctaacaag tctccctctc tagaacactg gttcccagtc gttgttttca 41460
tactagcaac attttaaaag caggataggg gtggctagta tgcaattgcc aactttggat
41520 ttttccaagc aggagtatat caaaaagcta caatttatta ccagtatttc
gtaaaagaca 41580 gtttgacacc agaagagtga aaaagaacat gggaatagtg
gacaaaaata gccatcagtt 41640 tgaataagcg tatgaaaagt gttaatttta
tgaaaaattc actattttgt tcatattttt 41700 cttattttgg aggctaattg
ttaaaagctt ttatcagtta tccatgggct ggagttggta 41760 gccactgttt
gataccacac aaatgtttct ttgccctaaa atatcaacat ctgtctgtgt 41820
aaaggtcagg gctgcctttt tagtaagagc taccctttgt taaacacatt gtacctgcac
41880 tgttcatggg tgtttcacac acacaaacct acctggtctg cataaacctg
aaatacagtc 41940 aagaaaacag gatccaccgg aggcggtgac tcaagcctat
aatcccagca ctttgggagg 42000 ccgaggtggg aggatcactt gaggccggga
gttcaagacc agcctggcca acatggtgaa 42060 accctgtctc tactaaaaat
acaaaaatta gtcgggcata gtggtacaca cctgtaatcc 42120 cagctactcc
agaggctgag gcatgagaat cgtttgaaac caggaggcag aggttgcagt 42180
gagctgaaat tgtaccactg cactccagcc taggtgacag agcaagactg tctcaaaaga
42240 aaagaaaaag aaaaacagga tcccagcctg ggcaacatag ggagacctcg
cctccaccaa 42300 aaattaaaaa tttagctagg catatggtga tgtgcacctg
tggtcccagc tactctggag 42360 gctgaggtgg gaggattgct tgaacccagg
aggttaaagg ctacagtgag ctgtgatcaa 42420 gccactgcac tctagcctga
gcaacagagc aagaccctgt ctcaaaaaaa aaaaaatcac 42480 tattgcccca
gcaatggatt taatttaatt taattttaat tttttttttt ccggaccggg 42540
attttggctc ttgtaccgca ggtgggagtg caatgggcca atcccagctc acgggaattt
42600 ccgcccccca ggtccaagca attctccttg cctcagcctc ccaagtagct
gggattacag 42660 gtgcccacca tcacacctgg ctaacttttt gtatttttag
tagagacagg gtttcaccac 42720 attggccagg ctggtctcaa actcctgacc
tcaggtgatc cacccacctc ggcctcccaa 42780 agtgctggga ttacaggtgt
gagccaccgc acctggccct aaggagtaca ttttattagc 42840 attttagttt
atttaatatt cattgttcta tttaaatttt cttattctaa ttgtgacgtt 42900
ttacattttt tcagttttta tacaggtttt gaatttatat ttcataatat ctattagcat
42960 gatgactttc acatttatac cttttattca gatggaattc atttttgttt
tgggggggtt 43020 gatggtttta acttctactt tagtttcagg ggtacgtatg
caggtttgtt atgtagttaa 43080 atggtgtgtc acaggagttt gctgtacaga
ttatttcgtc actcaggtaa taagcatagt 43140 acccaatagg tattttggaa
ttcatctttg ttgcgtgtta aaataggaat ctaattttgt 43200 ttctctttgt
caaatgagcc tactttctca tcatccatcc attcctttcc caaagactaa 43260
taggcccctt ttatcataca taaaatttcc gcatatatgt ggaaaggatt ttattttatt
43320 ctattctatt ttattttatt ttgagatgga gtctcactca gttgcctagg
ctggagtgca 43380 gtggcgtgat ctcagctcac tgcaaactcc atctcccagg
ttcgagcgat tcttctgcct 43440 cagcctccgg cgtagctggg actacaggca
cgtgccacca cgcccagcta atttttgtat 43500 ttttagcaga gacgtggttt
caccatattg gccaggctgg tctcgcactc ctgacctcgt 43560 gatcctccca
tctcagcctc ccaaagtgct gagattacag gggtgagcca ccgtgcccac 43620
ccaggatttt atttttgtct cacactgtcc tcttatcaat tcaaatgttt acaaaacaca
43680 aatactttct tttttaccat gtacctttaa cattcacaac aaccctgagc
agtattgtct 43740 ctgtttctta aatgagcaga tagagactca gaaaggctgt
atttagccta aaactcacat 43800 aatgctggat gacacaccaa gaattctgat
tccaaactaa ctgctctttt cccagattac 43860 ctcctgcctg tttaagcacc
tagtttctta tatctaattt catctattta tttaaatatt 43920 cattgaatac
ccatgatgtt ccagacacta ttctagcttc taagataacg gcagaaaaca 43980
agccagataa aaatctgtgc catcagagag cttacatggc agagggctca gggtagctct
44040 gaacacagag gtgacacctg agaaatacca tatttgatga caaagactgt
tctagtacct 44100 actttgtatc catccttcca aggggtctgg ggcttcagct
tgtttggaga gtcaaaggaa 44160 gtcctgtgga agttcccctg actctaacta
gtaactgaac ccccaagcca aagaaggcac 44220 ttgcagtcat ccaggctatg
actcttcctt tgggaaattt caacaatttt ctttactatg 44280 ccagagacac
cattttctgc tttcctctga catctgaacc aagttaagaa cttatctctt 44340
attgtctaac ccaactccct acagccatta tcaagcctgg tttcagaatg tcctggtaga
44400 gatggacagt ggagtttcca ccatcactaa agccctttat aaagagcttc
cttgtcattt 44460 agaaatgttt tcacacttaa gaccagaaat aaagtcaaac
tgatgtaatg cattatactt 44520 catagtcata gatcaattta agattactaa
aaattgacta caggatttaa tcatttaaag 44580 ggtactctgg tctatctcgc
tggctttagc agagaaaaaa ctaattcctg ataaacggat 44640 ggcaagatcc
aatttccctt ttaataaata gtaattggta gggggaaagg ggaaataggg 44700
acggaattgt taaaagatac aaaattacag ctagtggctg ggcccggtgg ctcacaccgg
44760 taatcccgac agtttggaag gctgaggtag gtggatcact tgaggtcagg
agttcaagac 44820 cagcctggcc aacatggtga aaccttgtct ctactaaaaa
tacaaaaatt agctgggtgt 44880 ggtggtgcat gcctgtaatc ccagctactt
gggaggctga ggcaggagaa tcacttgaac 44940 ccaggaggcg gaggttgcag
tgggccaaga tcatgcccct gcactccagc ctgggctaca 45000 gagcaagact
ccatctcaaa aaaaaacaaa aaaacaaaaa acaccaaacg aaacaaacaa 45060
gattacagct agacaggagg aataaattct agtgtcctat accactgaag ggtaaaacta
45120 gagttaataa aatatggttt caagtaacta gaaggaggat attgaatgtt
cccaacacaa 45180 agaaatgata catgtttgaa aggatgggta tgctaattat
tccaacatga tcactatacc 45240 tgtatgtttc gaaacatcac tatttnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 45300 nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 45360 nnnnnttgct
gctaaaactg aggtgtaggg cagtgaccaa ttttgggggg gtttcttatc 45420
cttttactgc cttggctgct gacagcatat cctgtcttga ccccaggcag ctctctccac
45480 tctgatgctg tgccctccac atgtcctgcc ctgatgctca gtctttccct
ctcccggttt 45540 aatccaagta gctctgcagg gtttggaggt ccatgcaagg
ggattttact ccctcctcag 45600 aatataggat gatggccttt ctttcctttc
ctttcctttc ctttcttttc ttttcttttc 45660 ttttcttttc ttttcttttc
ttttcttttc ttttctttac tttacttttg atggagtttc 45720 actcttgttc
cccaggctgg agtgcaatgg tgtgatctct gctcaccgca acctccactt 45780
ccaggttcaa gtgattctcc tgcttcagcc tcccaagtag cagggactac aggtgcttac
45840 caccatgtac agttaatttt ttgtattttt agtagaggtg gagtttctcc
attttggcca 45900 ggctggtctc aaactcctgt cctcaggtga tccacccacc
ttggcctccc aaagtgctgg 45960 gattacaggt gtgagccact gcccggctgg
atgatagcat ttcttaaggc tgctggtgcc 46020 aatgaggcag ggttggggtt
ggttatgcca aattttttgt aagatcccag aaattatttg 46080 ggccagaaaa
tccaaattgt atgcctaact ttgtaaccaa ctgtctctat gaccctgagc 46140
agattacctc acccctatgg acctttgggt cataatcttt aattgaaggg attagactag
46200 aatgaggttg tcaaacatct tcttaaagca tcagctagta aatgttttag
gttttgtggg 46260 ccgtattgcc tctgttccaa ctctgctgat gtagcatgaa
agtagccatg acaatatata 46320 aacaaatgag ggtgactgtt ccaataaaac
tttatttaca aaaacaggtg gccagcaggc 46380 atggtgtggt gcacctgtag
tcccacctat ttgggaggct gaggcaggag gactgcttgg 46440 gcccaggtga
ggatcacttg agcccaggag tttgaggcca gcccaggcaa cataatgaga 46500
cactgtctat aaaacaaaaa caaaacaaag caaagaaaaa aaaaagaggt agcaaacctg
46560 caagccatat tttgctgagc cctgcgtgag atgatgttta ggatctgatc
catttgcagc 46620 attctgtggc tgtatagccc tattaggagg tagtgactcc
tgctgcacag ctggtctgca 46680 tcaccctact tagcacttat tatatgggcg
ttcttgctct ttattgcttt gtgtgtattc 46740 gtgctgtctt cccatcaaga
gagtgaacag ttaggcagca tgaatggcct taaattcctc 46800 tacatcttaa
tgggaaccta gcaccttgct ggacattaat gaagcattac acaggtcggg 46860
tgcagcggct cacatctgta atcccagcac tttaggaggc gaaggtggga agattgcttg
46920 aacccaggag ttcaagacca gcctgggcaa tgtggtgaaa ccctgtatct
acaaaaacta 46980 caaaaattag ccaggtgtgg tggtcatgtg cctgtcgtcc
cagatactgg ggaggctgag 47040 gtgagaggat cacctgaatc tcggaagttg
aggctgctgt gagcgggggg tcgtgattgt 47100 cccactgcac tctaacctgg
gcaagagtga gaccttgtct caacacaaat aaacaagcaa 47160 aagaattaca
tgaaaatact aacagcaaca ataaacagct atcactgttg aggagtacag 47220
tatttattat ttgagtgtct aatcatcaag aagggctcat cctgcatgct ttttatctct
47280 cccaccccca gcaatcacag aggtggtaaa atgtgagcat gagcgagccg
tccacctctt 47340 tgttgactct ctggtgaatc aggacaagcc gagttttgcc
ttccagtgca ctgactccaa 47400 tcgcttcaaa aaggggatct gtctgagctg
ccgcaagaac cgttgtaata gcattggcta 47460 caatgccaag aaaatgagga
acaagaggaa cagcaaaatg tacctaaaaa cccgggcagg 47520 catgcctttc
agaggtaacc ttcagtccct ggagtgtccc tgaggaaggc ccttaatacc 47580
tccttcttaa taccatgctg cagagcaggg cacatcctag cccaggagaa gtggccagca
47640 caatccaatc aaatcgttgc aaatcagatt acactgtgca tgtcctagga
aagggaatct 47700 ttacaaaata aacagtgtgg accccttttg tgatgtggct
atcagtccat gatcacaata 47760 tcaatatctt aaatttctat cttgcattta
actttcaaag ctgtttcata tttgttttct 47820 catttgatca tcacaagaaa
cctgaggcag atgaacaggg gaccaaaatg acatgttaca 47880 tttttataat
gtgctgtaaa atcacaaggt tttctgggta ctgtgggtat tattttacat 47940
atgaggaagt tgaggctcag agaggttaat accttggtcc ttaatccagg ggcacgtagt
48000 tagaaagtag ctaagtgaaa atcctcaaaa gatctaactc ccaagtgcag
ggctccttcc 48060 atactgcagt ggcctcttat ggcattggac agaacaagag
cagatggggg ctgcaggctg 48120 ggctcaacca aaagaacacc agccctaaaa
tctctgtgct ggtgactcag tttgggtcag 48180 gggtctcctg tgatgacaag
caagggttac aagcatcttt gttctgctgt cactgcagtt 48240 taccattatc
agatgaaaat ccatgtcttc agttacaaga acatgggaga aattgagccc 48300
accttttacg tcacccttta tggcactaat gcagattccc agactctgcc actggaaatg
48360 taagtcatcc gtttcccttg ctgggttcgg gacagagaac aggttggttt
gagaatgaga 48420 gagcacaagg gagcgtgtga acgagtacag cacgcaggag
agtgcagtcc gactgctcag 48480 ggaggagcca ggtggtctag ctggcctctg
cagtcctctc tcccactgca ccttctctac 48540 caagccctga ctcagcgttt
cggggagaaa agttcctggg atgaatcggc atcatgagaa 48600 gctgctgggt
cagcagctgg atcagctggg cagaaactgc tgtttcattt caggcaatgc 48660
ctgacgatgc ttcaggcaat ctgtaacttc gtaaacgtca tcctggacct ctcctaatga
48720 tgtggctatg ggaggggtgc atagcgatct gtatatgttt gttgagtatc
caccagggac 48780 aaagcatcat gccaagtaat gttgggattg tgatgaaaca
tcatcaaagt agctcacttc 48840 tcagggctca cagtctagct gggagaccag
gtttgtacac gcacgtgcac acttacacac 48900 aggtagggca aggcagatga
ggccaagcca aatgagaggg acagacagga agaggctagg 48960 agtttggggg
agacagatgc ctgtctgtgg gatggatgag gtctgtgggg ggagctggtt 49020
ttccccagca tctgattttc agagcatcat taactctttc cttcagaggt tctaaggctg
49080 agcggaacag cgcacttgag tggggatgtg acttctttgt gttttcttat
tgtgttcttt 49140 cttggttctg tcttttcagg aagtagcata agtggggtgg
agggggtgcc caggaatcgt 49200 tttgataaga agctggggtg ctgagggcaa
agttagtttg gcccatatgg agtacacctg 49260 agcttccatc ttggtcctgt
tgataggaag tagagggata gaggtgggga aagcactcac 49320 actgtctctc
tcctgtctgt gtggggttgt tactgccact gtgtcacccc acacagtgtg 49380
gcagttttcc agctgttagg ggagtgagat cagcttctct cccacttgta gagtggagcg
49440 gatcgagcag aatgccacca acaccttcct ggtctacacc gaggaggact
tgggagacct 49500 cttgaagatc cagctcacct gggagggggc ctctcagtct
tggtacaacc tgtggaagga 49560 gtttcgcagc tacctgtctc aaccccgcaa
ccccggacgg gagctgaata tcaggcgcat 49620 ccgggtgaag tctggggaaa
cccagcggaa gtaagtgcct cctgctcctt cttctgcctg 49680 gtgtaggtgg
ggaacagaag gctgtgcctg tgacatttcc tttcctttgc tgcatctacc 49740
ctcaatcctt ccctccagca tgcaggtaaa acttcaaaca cctttgcaag gacaagtgac
49800 ttccagatca aggcttctat caaaactgtt acgcatctca tgccctgaac
atgggccctc 49860 agggagacgg gtgggccagt ggaggcagta attcagccct
ggctctgttt gccaggcctt 49920 gtgtcagcct ggaggagggg gacttctcct
ggactgggct ttttaggagt gctgccttgt 49980 cgatgtgttt actgtggggt
ccatgcagac aaaaggcttt gcttgcttct gagcaaagca 50040 gactggagta
tcacttccag agagccccca tggatgaggt ctgtgggagg aactggtttt 50100
ccccagcatc tgattttcag agcattattc tctctccttc agaggttcta agtcaaggat
50160 gtggggctgt ggtcctaact gcaagtaaca gagaatcctc tgtgccacac
tagctggcag 50220 tttcccattt cttttaaccc caagcctagc ataaaagatc
cagatctttc tatcagctcc 50280 taacaccgtg cctggactcc ctgagcaggc
ttttttctaa acagaagcca gggaagcctg 50340 cgagaccttt gtcaagaagg
gagagtttcc ttaaccaagt ccttcagctg acctctacag 50400 aggtcactgc
cagccttggc atgggaggag gcagctgcct ccctctttgt ccctcctctg 50460
gcattttctc cattataatt cctgccatgt ctggtttaca ttcgtcatct atgacacagc
50520 ttggcagcag agggaagtga agtggaggct tggagccctc agctgaatga
ttctagtcta 50580 gaaacctgtg aactgggggt gctggcctgt ggtctagact
gtgtatgttt ttacttctct 50640 gggcccttgc aggtacaaac tatacctatg
gatgtgagag cagaaagatg atcatttata 50700 aataaaatat ttcaaagaaa
ataaacacct attaaatcac cattgagact cacaaatgta 50760 aatagttttc
catttgggtt tagatatcag atttttaaaa agtaaaacat tatagataca 50820
gttgaagccc ctgtgtcctt ctctgctcta cccttcttct ttcaaaccaa atataactaa
50880 tatttcaatg ttaacaaatg ttagtgtgtt tccttccatc atgtttttat
acactttgta 50940 cttactgttt tttttgagac tgagtctctc tctttcatcc
aggctggagt gcagtggcac 51000 aatcttggct cactgcaaac tccgcctccc
ggattcaagt gattctcctg actcagcctt 51060 ctgagtaact gggattacag
gtgtgttgcc accatgccca gctaattttt gtatttttat 51120 tacagacggg
gtttcgccat gttggccagg ctggtttcag actcctgatc tcaggtgatc 51180
tgcctgcctc agcctcccaa agtgctgaga ttacaggtgt gagccaccat gcccagccgc
51240 cttagtactt ctgtctgtgt acataaacaa tgtatagaat tttggatgct
tctgaatttt 51300 acatgagtgg acataatatt ttacaatttg attttttcat
tctaatattg tttgtgaaat 51360 ttatccaaaa cataaagatc taatctattc
ttgtttaact cctgtatgta aatcaccatt 51420 gcacaaatag ttttgccatt
gttctgctga atagttgagt tgttgctttt ttgtagttac 51480 aaatggtgct
gagatgaaca tcctctgcat tttccttgtg cacatgtgtg taagggctgt 51540
ttctcagcat gtgttctaaa aagtggaatt gctgggttgt agtatatgca ttctccagct
51600 tgaacagata ttgttaaatc tgtctccaaa gtggttgaac taattttcca
tcttaactat 51660 ggatgaagag ttcccttttc cctccttttc acccaggtct
ggtgggacat tcttgtcatt 51720 ttgttaggtg tgaatgggcc ccctgctgtt
gtttgaattt gcatttcctg attgtgcgtg 51780 agataggtca tgtttttata
tgtgtataaa catataggtc ctaaggtcct tagggcttcc 51840 tgggaaaggt
tcttaagctc ttctgaatgg ggcttttgtc ctgcctcagc tccagggtca 51900
ggtgccccac acccttaagg attacgtggt cacgctaatc acacgcccct gaggctgcgt
51960 ggggcagcca taagttacat ggaaatggtt attaggccct gattctttct
tgtggtcttg 52020 gctgtccatt tgctgaatct ttggttttga cttgcagctg
agttgcagtt gnnnnnnnnn 52080 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 52140 nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nccagcagca gcggaaagaa atatcctgga 52200 ggaagttgaa
ctttaccctg cttgggaatc tatccaggtc tgaagcccct ctaccgaggt 52260
ccccagaatg ttccccgctt tccccactga gtctgctggg gagtaaagtc caagatgaca
52320 gctcagttgt tcccacgtgg cagtgtcctc tgagggatcc aaataaacct
ggagttttat 52380 tatcctgact gtgccgataa ggagactggc cgacctaggc
agagaaagtg gaggccactg 52440 tccggtatct cttggcaggt cacactcatt
ccttttctgt tcacatcagc tgggcttgta 52500 acagctccca gtgatagcgt
atccaggctg gtcacccgac ggtggagtct tgtccatttg 52560 gaaggcccag
accaatgact gaagtaaact actcacccca caatttactg ctcctagaac 52620
aaattgcttg tcttggtgat aattctcttg tgtatggctg aaactatcag ctctgggata
52680 atgtgcataa ctttgcatgg attgataaag ctccatttat ttatttggct
aaacagagtt 52740 attacactat tacttcttct atgagtttct gacataaagt
cagacaaact caaatgcaag 52800 cttatttatt tatttattta tttatttatt
tatttattta tttatttatt tttgagactg 52860 agtcttgctc tgttgcccag
gctggagtac agtggcgcaa tctcggctca ctgcaagctc 52920 cacctcccaa
gttcaagtga ttctcctgcc tcagcctccc gcatagctgg gattacagat 52980
gggcaccacc acgctcggct aatttttgta ttttttagta gagacagggc ttcgccatgt
53040 tggccaggct ggtctcgaac tcctgacctc aagcgatttg cccaatttgg
tctcccaaag 53100 tgctgggatt atgggcatga gccaccatgc ccggcctcaa
atgcaagctt ttctatcatc 53160 atactaatcc tgctgaatga atttggagct
caattcctat gggggggcaa gagcctagag 53220 gtcaaagctg tcctcttgaa
tcctggtgtc gttgatgcgt gcataaggct ttgcttgttc 53280 atactctctc
aggcagaagt gtaatttgag gaaaatgtag tgtgcatgtg tgtgtgtgca 53340
catgcacatg tgtgcataca tgtcctataa gaatgagaat gggtgcccac ttttcttggc
53400 tcctctccct tgtgcctctg ggcctttctg cctgaatgca cttgcctgga
aatccttgtc 53460 gatctctctc attcaatgac cagagcacca actatggagt
ttggaaacct ggctccagcc 53520 ctgattctgg cattgacatg ctgcataaca
ttggtgaaag caactggcct ctttgaacat 53580 cccttcctgg tgtgtggcag
gaaacatttg gtttccttga actgaacccg cctgacaatg 53640 ggaagatttg
cctgaaccac ctcccctgct gggtagctat agggattaaa tgatgtaaca 53700
gaaggtaaag caggattatt ttttaaactt ttatctattt ttaatgccct cctatgtatc
53760 ttcaaggcca gagccttctg agacactcca gcccacggtg actgctctcc
tcttatctgt 53820 cacttcttta gccttatact gctttgctta ttatgatcta
tttatgtgtt gcgctttatc 53880 cacttgtctt gtccataagc tctttttctg
cccttttgaa tcttttcagt ggctagtgtg 53940 ctgccttcat cataactgat
ttcagtatgt ctttccagat tgactactta attgaatttg 54000 gaatatgggg
aaggagactt agtgtaaagg gaccacccaa tacaaggtct gagattattt 54060
tatgccatat ttcatggtgg aataaggaat gaataacaca atctgaatga ataatgcagt
54120 gtatcatgag ttgggaaggg agaaaaaaaa gagtatttgt acatgtcatt
ttttctttct 54180 ttcttttttt gtttttttga gatggagtct tgctctgtta
cccaggctgc agtgtagtgg 54240 cgtgatctcg gctcactgca acctctccct
cctggggtca agcgattctt ctgcctcagc 54300 cacgcaagta gctgggatta
taggagcacg ccaccgcacc tggctaaatt tttgtatttt 54360 tagtagagat
ggggtttcac cgtggtggcc aggctggttt caaactcctg acctcaaatg 54420
atccgcctgc ctcagcctcc caaagtgctg ggaatacagg catgagccac tgcgcccggt
54480 atatacatgt cattttcaat cattttgacc tgaatcacct ggttttatct
ggtcaatgaa 54540 agcagaggac aatggtcaaa cttactattt gggtcttttg
agacaaagta accagctgat 54600 cgactgtctt ttctgctcag cagaacttgc
tggccctgga agccatgagg agtaactgaa 54660 ctgaggcgaa taggctcata
gctggggagg aaacagcaac atagcaacat ttttactttt 54720 gccttattgg
tgtaaccttg ttcacaagga agacatggaa gggaaaggac ttggagagtg 54780
agagaggaaa cagaaaagaa agattgtgag gaagggccag gaggaagcaa atagagcttc
54840 cagttcatgc ttggggagta ctcaaagtgt ccatgggaga gctacgggtg
gttgcttcat 54900 atgcagggag aggcctggcc agacccacct tcctcccagc
tctgacccca gagtgaggtc 54960 agtgtccagt ttccacgtga acgatttgca
gaccccaccc tttccccagc aggtagcaaa 55020 ggccacctca cttgtgtcta
tgcacaagcc tgggctcaga gattctctca agccctagtg 55080 tcagtgctct
ccagatcaag aggaccaaca gagtatatat ctatagagaa gtttatttta 55140
aggcattggc tcacgtgatg atggaggctg gcaagtccaa aatctgcagg gtaggcctgc
55200 agcctggaaa cccagtgaag aattgcagtt tgagtccaaa ggcagtctgc
tggcagaatt 55260 ccttcttgcc cctgagcaag aaggaattat tttctatgca
ggccttccac tgattggatg 55320 aggcccaccc attcaatgga gggtcatcta
atttactcaa agcctattga tttaaattta 55380 atctcattcc agcactttgg
gaggtggagg tgggtggatc acttgaggtc agggagtcga 55440 gacnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 55500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnttttcaa aaaaaaaaaa
55560 aaaaaaaaaa aagaaccatg tcttcatgaa gcttacattt tttgaaaagg
agatagaaat 55620 ttaagaagaa aactaataaa tgtgataatt tcattcagtg
agatatgttg tgaagacaat 55680 aaaacaagat tatgtcagag aggagctcca
tagactgagt gtcagggaag gagttaaggc 55740 ttcagtgact ggaagaagcc
aacacgtgaa gacctagttg taaatcattg gaaggaaggg 55800 caaaagcaaa
ggcatcaaga caggaatgag ttgactgtat ccctgaagca gcaaggagcc 55860
aatgtggctg gagcaaagtc agtgcagagg aaaagtatag gaaatgaggg cctggagcta
55920 gatcagcctg cacagcacag taagcagttt ggactttatt gggtgtgaaa
tgtgaagtct 55980 ttcaagggtt ttaacctggg aagtgctttg gagagaagtg
gggagtgtta tattatatag 56040 tttatatttt ttaaagatta cattttctgg
ttatagttat catagttcta gaaactgtat 56100 tttaggacaa ccaaatcacc
ccagttaata agagaaagct ctttttacaa agaatgccaa 56160 gctattcaga
ttaaagaaaa ataaagagac atggcaacca aacacaatgc cttattctga 56220
atttggctct tcgtccaaaa aaaattctat aaaagatatt gttgggaaaa ttggcggcaa
56280 ttaaatatgg tctctaggtt agataatatt attatagtaa atgttaaatt
ttctgattct 56340 aaaactgatt atgaaagaga acaacctggc caggcacggt
ggctcatgcc tgtaatccca 56400 acactttgga aagccgagac gggcagatca
cctgaggtca ggagttcaag accaacctgg 56460 ccaacatagt gaaacccagt
ctgtactaaa aatacaaaaa ttagccaggc gtgatggtgg 56520 gcgactgtaa
tcccagctac tcaggaggct gaggcaggag aatcacttga accccggagg 56580
cagaggttgc agtgagccga gattcgcgcc aataccactc tagcttgggt gacagcaagc
56640 ctcctgtctc aaaaataaaa ttataagaaa caacaaccag atgtcatgtg
ggacctagat 56700 tgggtcttgc tttgtttctg gtttttttgt gtgtgtgtgg
ctgctttggt tggttggttt 56760 gtttgtttgt ttgtttgttt gagacagagc
cttgctctgt cacccaggct ggagtgtagt 56820 gacatgatct caactcactg
caacctctgt ctcccagctt caagcaattc acatgcctca 56880 gcctccagag
tagctgggac tacaggtgtg tgccaccaca ccctgctaat tttttctatt 56940
tttagtagag acagggattc accatgttgg ccaagctggt ttcgaactcc tggcctcaag
57000 tgatctgcct gcctcagctt cccaaagtgc tgggattaca ggtgtgagtc
agtgtgcctg 57060 gcgggtcttg ctttgaacaa accaactgga aaggacattt
ggggaacaac tgggataact 57120 gaaattgagg ttaggtatta gaagagatga
aaatgtatca acatggtaaa attgagatta 57180 actggaaaaa aatctgatta
tgaaatagca tgtacagtat aatttcacct ggtaagtata 57240 tatgtatata
catacacaca tgaagtatat atctcacact atactagaag gatatattaa 57300
agcttaatct tttggaaata taaggatttt attttcttaa tctgcttacc tgctatatct
57360 gactttctat aaaacacata taaataatct taaatttttg aataatttta
aaattttact 57420 tattatttat ttatttattg agatggagtc actctgtcac
ccaggctgga gtgcaatggt 57480 gcgatcttgg ctcactgcaa catctgcctc
ccgggttcaa gagattctcc tgcctcagcc 57540 tcccgagtac ctgggattac
aggcacgcac caccatgccc ggctaatttt ttcttttctt 57600 ttcttttttc
tttttctttt ttttttttga gacagagact cgctctgtca cccagactgg 57660
agtgcagtgg tgcgatctcg gctcactgca acctccgcct cccaggttca agccatgctc
57720 ctgcctcagc ctcccaagta gctgggacta caggcgtgtg ccaccatgcc
cggctaattt 57780 tttgtatttt tagtagagag agatggggtt tcaccgtgtt
agccaagata atctccatct 57840 cctgacctcg tgatccacct gccttggcct
cccaaagtgc tgggattaca ggcgtaaggc 57900 atcttgcctg gcaacttttt
ctatttttag taaagacagg gtttcaccat gttggccggg 57960 ctgatcttaa
ctcctggcct caagtgatct gccaccccgg cctcccaaag tgctggggat 58020
acaagcgtga gccaccgcac ctggccaatt ttaaattttt taataaataa attgctctgg
58080 ctgttctaga tggattacag gggcaatcaa gagtggaagt aggttgtcta
gttgatcagc 58140 aatatgcttt tcagtatctg tttcccaagt ctaggtggaa
gccagattct tgctggaaat 58200 gaagcttctc cttcatggga atcccacata
catggccaaa gagatcttac gtctgggagc 58260 acaaactggg tatgttaaag
ggcttgatat tctccagggt attttgttgt ccaacaaagc 58320 tgggtagaga
tttgcacagg tccacggagc tgctcagcaa agggagggtc tggaggagtg 58380
ctatccagca gactaaaggc aaggcaccag ccctctttga agttatacac tggtccagcc
58440 agggaaatca caagcacaca cacataccca acatcagtta atgacaagat
aagaaagaaa 58500 atgtactttt aaatttgatc ttaaaacaat tcacaactct
taaaaattat gcagaataag 58560 ccaggcgtga tccaccaagc ctggtccatg
attaatagta aatgtgaagc atccggccac 58620 aacacgtggt ataggctgaa
tatccctaac ccgaatatct gaaatccgac atgttccaaa 58680 atcgaaaact
ttttgagaac caacataaca ccacaagtgg aaaattccac acctgacttc 58740
acatgacagg tcacagtgaa actgcaggtg cacaagccag tttatttaac atacccannn
58800 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn 58860 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnngcc
tctgttattg cagctgaata 58920 accatcccaa agtcaagcaa tattgtgtgg
gattctggag aattgagaaa tagcaaaata 58980 atttttgatg gaggcagctg
gcagggctag ccctgcctgc aaagttgtcg gaaaggacag 59040 gtcccacggg
aaagagtagc aatatgagat agtgccaaaa ctatggaatt tgaagtcaaa 59100
tgagctgagg tttccacact gacgtctttg agcaattact tcacctctct cagccagttt
59160 cctcacctaa aatatatgca tgatgatgat tctgccatta caggaaatgt
tgacatgact 59220 gtagtaataa caattcacat tatggattat tttctatttg
ccatgcacta ttatttcgca 59280 aaatgaccct atggaacaga tagcaccgtt
attcccatta tatagtcaat atgtgccagt 59340 gtactctgta aagtactata
caaatattag gtattctttt ctagcataga ctgccagtaa 59400 attcactgag
cttgcagaat tatgacagga aaacatatta aaacccaaag tagactgggc 59460
cctgtggctt atgcctgtaa tcccaatact ttgggaggct aaggtgggag gatcacttga
59520 gcccaggagt tcggaaggac cagcctgagc aacatagcga tacactgtct
caacaaaaaa 59580 tacaaaaatt agctgggagt ggttggcaca ccctcggtcc
cggctactcg ggaggctgat 59640 gtgggaaaat cgcttgagcc cgggaggttg
aggcttcagg gagccataat ctcaccattg 59700 cactctaccc tgggcaacag
aacgagacac tgtctcaaaa aaaaaaaaaa cccccaaact 59760 acctaactaa
aaagccatag acactactat gcagtcattg taaagaatgc tatggatgca 59820
tatttatttg aaaacatttt catgatacac tgagtggaaa catatatagt atcaaatttt
59880 cataagtgaa ttatattagg ttggtgcaaa actaattgtg gttttgccac
ttaatataat 59940 atttatatta atatattaaa tgatatatta atataacata
tgtaatatat gtttactata 60000 atatttataa tacctatgta tatgtgctgt
tggaaaaaag acaaataata ttaacaatat 60060 tgcaactttg ggtaatgaga
tcctgtgtgg ttaaaattag tttttcccta tgttttctaa 60120 tttttctgca
aggaatatga agtacatgta caattttatt ttaaaattac agcaaaaaga 60180
gactcagggc tgggcgtggt gactcatgcc tgtgatccca acactttggg aggccgaagc
60240 aggcagatca cctgaggtca gcagtttgag accagcctgc ccatcatggc
gaaaccccgt 60300 ctctacgaaa aatacaaaat tagccaggca tgcgcctgta
gccccaacta ctcaggaggc 60360 tgatgcagga gaatcacttg aacccagacg
gtggaggttg ccacgagccg agatcatacc 60420 cctgtactcc agcctgggtg
acagagccag actctgtctc aaaaaaataa aaaataaaaa 60480 aagagactca
ggcatgaaaa cctaactcaa aatatttttt aatattgcct ggcacacagt 60540
ctactttccc cagactgact cagcaacagt tgtgagcatc tcctcaaaac tggctttata
60600 gacctaagaa gcaaaatatt ttatttcaag gggatcctat tagtgaaatt
ttacatcgtc 60660 tccctttggt catttttgga tgacttgaaa taaacagtct
tgcctgtgtt cctaggcaaa 60720 tgttataatg ttgctaggca aatatcataa
atcggaagat aagattagga atatttttta 60780 ctacgtagga agtgttgagt
tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 60840 nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 60900
nttacctccc ccaagacctc accctttttt tttttttttt gagacagagt ttcactcttg
60960 ttgtccaatc tggagtgcaa tggcactatc tcagctcaca gcaatctctg
tttcccgggt 61020 tcaagcgatt ctcctgcctc agcctcctga gtagctggga
ctacaggcgc acgccaccac 61080 gcccagctaa tttttgtatt tttagtagag
acggggtttc accatgttgg ccaggatggt 61140 ctcggtctct tgaccttgtg
atctgcctgc ctcggcctcc caaagtgctg ggattacggg 61200 cgtgagccac
cgcgcctagc cctggtttgg tttttttttt tagagacagg gtctcgctca 61260
gttgcccaga ttggagtgca gtggcatgat catggctcac tgcagctgcg atctcttggg
61320 ctcaagcaat cctcctgctc cagactccca agtagctagg actacagctg
tgcaccatta 61380 cgcccagcta tttttttggt agagatgggg gtctcactat
gttgcttagg ctgagctgga 61440 actcctgacc tcaagtattc ctcccttctc
agcctccaaa actattggaa ttgcaggcat 61500 gagccactgc acctagcccc
catgttaact attattagtt tgtgactttt cctaatttgt 61560 cccagacagg
aaggagacag tgacagctgc actgtgcccc ctccctaagt tctgccatca 61620
gaactgctcc tctgacatct tttctgatgg ccagaaggcc accaggaccc atagtgatca
61680 ggctgtctca acctctttcc ccaggctagg ctaagggctc aggaaaagga
agaatgaatg 61740 ggggctctgt agagtgcatc taagctctcc tgcatgcagg
agggactgga gaacgaactg 61800 tgtagcttct taccttatca ggcaggcaat
acccaggaat gctggagtca ctgcttttgg 61860 agcattcaaa ctctctgcag
cactttctga gtcttgctgc taacagctgg ccttgcaagg 61920 aattcattac
catagcacca caggaggcct tagaggacgc cggttcagga gcttgctcag 61980
tcatttgtgc agctcactgg ctgtgcatct ctgtcggaat cctctcatgt ccctagaact
62040 caaatcacta acattcccta cgctgttgta actttatttt actacctgtt
cagccagcct 62100 ctgcttgaac acatgcagtg attgggatct catttctctt
ccacatagac catttcacta 62160 ctagtaagct taatttcact gaaccaccta
tggtgaagtg attcctgagt cattaaataa 62220 ctttctactg caccctttct
catagggtta tttggagact taaataagat aacagtgcct 62280 tgctcacaga
aaacagcctg taatgtgaat tgacaattat tgctgctgat attgttttca 62340
gaaagttctt atatggagct gaaatctgca ttctgtaact tcgaaaactt ggtcttaatt
62400 tggctcattg gcataacaga aaataagtct aatcatgccc gcctgaggat
ggttctactt 62460 atcacaagtc tcctcttagt ctagttcttc atactcagtt
ccttcagccc ttccacatgg 62520 gacgtaattt ccagatctct caccatcctg
actgcccttc cctggacagg ttctgtttga 62580 ccttcatccc tccttggagg
agtggccagg tgctggcaac taagacatgc gagctgtcca 62640 ccatctggat
tatgcagatg aactaacatt gaaaatgaca cgctacatgc attacttaat 62700
ttcgttctca cagcaccttc atgaggagaa aactgaggct cagagatgtt aagtagcttt
62760 ccccaaatcg tttagctcag aaattgtgga accagaattc aacccagatc
tgtctgactc 62820 caaagtctgc tcttctttct tggggaagtg gaagcctgag
tgctgttctt ggaacagcct 62880 caagacaata atctggggac tgtcttggtc
ctgcttgcag agggtccttc tgttacgtat 62940 gggtcctttc tggcccttta
gcttctacaa agaaagtcag tccccctcca gctctaaaga 63000 cacatgaagt
ctgtttgcag tccagacctt gcaaacttgt agttatagaa acctcagagg 63060
cctaccaggg cttgaaggat atttggctcc actttacatc tccattcttc ttttcctcct
63120 gtttttaatg taacctgtaa tcctagcaat ttgggaggct gaggcaggtg
gatcacctga 63180 ggtcaggagt tcaagatcag cctggccaac atggtgaaac
tccgtctcta ctaaaaatat 63240 aaaaattagc tgggctaatt tttaattagt
gtggtggccc gcgcctttat tcccagctac 63300 tcaggaggct gaggcaggag
aattgcttga acctggaagg cggagattgc agtgagctga 63360 gattgtgcca
ttgcactcca gccttggcaa caagagtgaa actccgtctc aaaaaaaaaa 63420
agtattctgt ccaccacgtg gaataatgta atatttagta ataagaacag ctgcaaggtg
63480 tagagagtta ccgtatatcc atcacccagc tttccttaac gttaacattt
tatataacca 63540 cagcatcatt ttgtcaaaac tagataatca gcattggtac
aatactgtta actaaactct 63600 aaacttcatt taggtttcat caggctttcc
actattgcct ttttcaattc caggatgcan 63660 nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 63720 nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt ttataagatt ttaaaactgg 63780
caaaaaatat tatggattta ttcatagcta gtaccagcat taaaattttt tttttttttt
63840 ttttttttaa gaaacagggc ctcactctgt tgctgagtac aatgctggag
tacagtggcg 63900 tgattatagc tcattgtaac ctcaaactcc tgggctcaag
ggagcctcat tgcctcagcc 63960 tcctaagtag ctggaactac aggtacatgc
caccaaagcc cagctaatat tctgttattt 64020 ggtaaagatg gggtctcact
gtgttgccca ggctggtctc gaactctttc tgccttggct 64080 tcaaccacag
tgctgacatt acaagcatga gctactgagc ctggccaaga ggaattaatt 64140
taactagaaa tctatagctt ttcaagctac caattaagtt tgaaagtaga ataaaaacat
64200 tttctgattt gccaagattc aaaagacctc ccaggaacct acaaggaagc
tacaagatgt 64260 actccttcca catgagggaa caagccaaga aaaaggaaga
aattcaagaa acaggggatc 64320 caacacaggg cagtggtata gagaatcaca
gccatgcagc aggctgggac aagagtcaaa 64380 acagctcccg gatcaaccag
gagaagaaag catagaactg acggttcact tgatgcgtct 64440 aaccttattc
tgtggaatgt tacaatactg taggagaatt tggaagcaat gaataatagt 64500
tatatggaga ataaagtaaa taatttcgta tagactacaa actttgggaa aaacaagtta
64560 ttcaagaaag gtcatgtaat catagtatac gactaaattc aacagtaatc
aacatttata 64620 taatcactat gatataaata ctaaatattt aaccaaaaat
tgtgagttaa ctctactgag 64680 aagattccag aagcagcagc aggattggtg
gtctacgagt gctaaacctt catcttccat 64740 aataggtagt gctcaataga
aaatatgtaa agttagtaaa tcaaaaaaca gtaaaaattt 64800 attagttata
aataaggaag tagggccagg tgtggtatta tcccaacatt ttgggaggcc 64860
gaggcaggtg gatcacttaa ggccagaagt tcgagactaa cctggtcaac atagtgaaaa
64920 cccgtctcta ctaaaaatac aaaaattagc taggcatgtt ggagcatgcc
cataatccca 64980 gctcctcagg aggctaaggc acgagaatca cctgaacctg
ggaagtggag attgcagtga 65040 gccgagattg tgccactgca atccagcctg
ggcgacagag tgaaactctg tctcaaatta 65100 aataaataag gaggtaaata
gcaaaaagca acagcttata gatttttaaa tggtggccag 65160 gcgcggtcgc
tcacacctgt aattccagca ccctgagagg ccaggcggat gggtcacctg 65220
agacaggagt tgagaccagc ctgaccaann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
65280 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn 65340 nnnnnnnngc ggttcacgcc tgatatccca gcattttggg
aggccaaggc aggcgaatca 65400 tgaggttaag agatcaagac catcctggcc
aacatggtga aacctgtctc ccgttaaaat 65460 accaaaatta gcccggcatg
gtggcaggta taatcccagc ttacttggga gactgaggca 65520 ggagaatcac
ttggacccac ggaggcggag gttgcactga gctgagattg cacccttgca 65580
atgcagcctg ggcaaccatt gccaaactcc atttccaaaa aaaaaaaata ttcttagggt
65640 ttggggcttt tttggggggg gttggggtgt aactatggta aatgggatta
ccttttaaat 65700 tttttttctt ttttttgaga tgggagtctt gctatgttgc
ccaagctggt ctgaactact 65760 gggctcaagc aatctgcctg cctcagcctc
ccgagtagct gggattacag acgtacacca 65820 ttgtgccatc ttgatttctt
ttcttgtttg tgtctagaaa tgctacttgt ttttgaatac 65880 tgattttgta
tcctgcaact ttactaaatt cacttattag ttctgagact tattgagtag 65940
agtctttata tttttctcgt tttttgagac agagtcttgc tctgttgccc aggctggagt
66000 gtggtggtgt gatctcggct ctctgcaacc cccacctccc aggttcaagt
gattttccta 66060 cctcagcctc ctgagtaact gggattacag gcatgcacca
ccacgcccag ctaatttttt 66120 tgtattttta gtagagacag ggtttcgcga
tgttgaccag tctagtctca aactcctgac 66180 ctcaagtgat ccaccatcct
ctaccaccca aagtgctggg attacaggca tgagccactg 66240 cgtccggcct
gatttttcta tatataaaat catgtcatct gtaaacaggg actattttac 66300
ttccttcttt tcaaattgaa tgtccttttt tctttctttt gcctaattgc tctggctagg
66360 acttccagta ttatgttgta attcaagaaa tatttgttga gaacttatca
taaacaaaaa 66420 aattattcta ggcactagag gaaaataata cagacaagaa
ctatgtcttc tgccaggcac 66480 agttgctcat gcctgtaatc ccagcacttt
ggaaggtcga ggtgggcgga tcacctgagc 66540 tcaggagttc gagaccagcc
tggccaaaat ggcgaaaccc cctctctact aaaaatacaa 66600 aaattagccg
tggtggcatg cgccggtaat cccagctact ggggaacctg aggcaggaga 66660
atcatcgaaa cccgggagtc ggaggttgca gtgggcacaa gatcacgcca ctatactcca
66720 gcctgggcga nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn 66780 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn cttttttttg 66840 ggggtttccc cggccccccc cttttttttt
tttttttttt tttttttttt tgtgagaccg 66900 agtcttgctc tgttgcccag
gatggagtac aatggtgcaa tctctgctca ctgcaacctc 66960 cgcctcctgg
gctcgagcag ttctcctgct ttagcttcct gagtagctgg gattacaggt 67020
acccaccacc atgcttggct aatttttagt agagatgggg tttcaccatg ctggccaggc
67080 tggtttcaaa ctcctgaccg taaatgatct gcctgccttg gcctcccaaa
gtgctgggat 67140 tacaggcatg agtcaccatg tctggcctcc ccatttaaaa
tggcaacccc tgccctgcct 67200 cctagcacct ctgtctcctt cctctgcttt
attttctcta gaacacttac caccacctga 67260 catattatat atcttaacta
tttctttgtt tacagtctgc cttccctgct aagatgaaag 67320 gcattcttgt
ctattttgat cattgctgta tttccagtgc cagtacttaa taaatacttg 67380
ttgaataaat gcatgataaa ttctgaagct atttaaactt tttcaattgt actgagcacg
67440 ggctcagtac aaggaaatct acacacatag tttaccacat ttacacatca
aaggtggatc 67500 aaaaattttt tcaataggca tttgaaaaac attagaaatg
aaatacttta ataacaaggg 67560 tgattatata cttaatatac aaatgtctct
acttttttaa ctcagtggta agaatttact 67620 ttttcaatct cataaagaag
ggctctctaa gcaagatata aacacagaaa ataaaaggga 67680 aacataataa
acttggctat acacattttt ttttttgaaa cagtcttgtt ctgtcaccca 67740
ggctagagtg cagtggtgca acctcagctc actgcaacct ccacctccca ggttcaagca
67800 attctcatgc ctcagtctga gtcatgtgcc acccgcccca acccacccca
ccccaccccc 67860 agctaattgt tctattttta gtagagacag ggtttcacca
tgttggccaa atttgttttt 67920 aactctgatg aaaatgagtt aaacaaagtc
aaagataatt taaactaagt cacaaaatat 67980 tgcaacatat aagannnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 68040 nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnaccaca 68100
gaatcagcaa cagttcacat agggcaaatg ttttaaataa acatttttta aactccatgt
68160 tgcaagaagt agcaacacta acaaaagcaa tatttatata aggacatact
ttgtaaccag 68220 tttaaaggcc aagggagggt taggttaatg agggctcagg
cagtcaggaa ggcttctgag 68280 aggctatggc cttgagaggc aggtggcctt
ttggatagac agaaggaagc aggtggcaga 68340 ggtctggcag aggctgcatg
aggccgaatc atggaagcct caaagtgaga cacaggttag 68400 agtccctgca
gtagtgatgg ggaattctga aggcttttga gtcggggcat ggcatgaaaa 68460
tttcacccct gcctcctcac ccatctgcct tgaatctaga aagcacagct ggattccccc
68520 taaagttctg cctacatcag tggtttcttt tccctcctag actgacattt
tgtacagaag 68580 accctgagaa caccagcata tccccaggcc gggagctctg
gtttcgcaag tgtcgggatg 68640 gctggaggat gaaaaacgaa accaggtaac
caggactttc tcacacgttc cacccaggac 68700 acgttgacat gatgatctcc
tagcatgtgc tggggatgga tctgggtgcc agggacatag 68760 catgaacaaa
acagataaaa atctcttcct ttaagaagtt gggccgggcg tggtggctca 68820
agcctgtaat cccagcactt tgggaggcca aggcaggcag atcacctgag gtcaggagtt
68880 tgagaccagc ctggctaaca tagtgaaacc ccatctctac taaaaaaaaa
aaaaaaaaga 68940 atgccgggca tggtggtgtg tgcctgtaat cccagctact
tgggaggttg aggcaggaaa 69000 atcacttgaa cctgaaaggt ggaggctgca
gtgagctgaa accgcaatgt tgcactccag 69060 cctaggtgac agaaatgaag
ctctgtctca aaaagaaaga aagggccagg catggaggct 69120 cacgcctgta
atcccagcac tttgggaggc tgaggcaggc ggatcacgag gtcaggagat 69180
cgacacaatc ctggctaaca cagtgaaacc tcatctctct aaaaatataa aaaattagac
69240 gggcatggtg acgggtgcct gtagtcccag ctactcggga ggctgaggca
ggagaatggt 69300 atgaacctgg gaggaagagc ttgcagtgag ctgagattgc
accactgcac tccagcctgg 69360 ggtgacagag tgagactccg tctcaaaaaa
ataaaaaaaa aaaaaaaaaa nnnnnnnnnn 69420 nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 69480 nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn aaaaaaaaaa aaaaaaaaaa aaaagaagct 69540
gaccttctgc taggagataa agaagcaagt gaaatactgt agataggatg ttggaagtgt
69600 taatgtctct tctgctcttt gtcctgcctc aacctgtagg ggttcattgt
acatgaccct 69660 actggcatga gatcttctct gtaactaagt ccccaggttg
gtgcccattc ctgccatctt 69720 tgaagtatct tttttttttt cctttgagac
atggtcttac tctgttaccc aggctggagc 69780 gcagtggcat gatcctggct
cactgcagcc tcgacctccc caggcttggg tgatccttcc 69840 gcctttgcct
cctgtatagc tgggaccaca ggcacttgcc accacgctga gctaatttgt 69900
gtattttttt gcagagacgg ggtttcacca tgttgcccag tctggtcttg aactccatgg
69960 ctcaagtgat ccgcctgcct tggcctccca gagtgctggg attacaggtg
tgagccactg 70020 tgcctggccc ctgccatctt tgattgacat cttctctgta
ataactagag ctgtgggaac 70080 gtgcctaagg gctcctagct tccttctggc
caccaggtca ggtttgggaa tggggtggga 70140 gataaagaga agcacaaagc
atgttctcct ttcttaggtt ttctagaatg caggtaagtg 70200 tgggcctaat
tctcccacac actttttttt tttttttttt gagacaaagt ctcactctat 70260
cgctcaggct ggagtgcagt ggagtgatct tggcttacta aaacctccgc ctcccgggtc
70320 caagtgattc tccttcctca accttccgag tagctgggat tacaagtgcc
tgctaccacg 70380 cctggctaat ttttgtattt ttagttgaga tgggttttcg
ccatgttggc caagttacca 70440 tgttggccaa gttggtctca aactcttgat
ctcaagtgat ctgcccacct tggcctccaa 70500 aagtgctggc attacaggtt
tgagccacgg tgcccaaccc caatccttcc cctttttggg 70560 aaacagaaat
gcccatgtat gtggagctaa gtgagacaga ggggttgtca tgcttcacta 70620
tccccttgtc ccatgctgca atccgttatt tcagacgtga ggaaggccca tcttgtggtg
70680 tgaggcagtg ggctcatcct ggggaacagc cacacgccct ctaagccaaa
acacctgcta 70740 aggaggaagg agactgtctc ctcacaccat gcctgtcgcc
accctttgct ctaacaaggg 70800 tactagataa taatactgct gtggtacacc
tagcacttag cttgggccca gcctgcaccc 70860 agggacttac ataatgatgt
ttgtcatcaa cccactaggc aggggttgtt agccctgtgt 70920 acagatgagg
aaccgaggct cagggagatg aagtttctct cccaaggccc ccagcaatgg 70980
cagagggagt tgaagcaggt cggtctaccc caaagcctgt gttgttgagc accgaggctc
71040 caagtgctca gatgatcacc tcgcgtctgt ctgggtatca attatcaggc
agctgtgccc 71100 gtgctccggg gtcgcctgtg attaaccatt tgccaccccc
aaggctgcgc tgcatcccag 71160 ctgctctgtc tcctggttag gagctcaaca
caaccacaag caccatcatc acaggactcg 71220 tgccatctaa ttaagggact
cagtctagcg taggctcgta tgattttcta ctactataac 71280 gattgtaaat
ctttatgtat ttaaatgtgt acatttcaaa gtgtttccac atatattaac 71340
ttcattgatc ctccagacaa ccatgtagat tggacacacc caggaaagat gactaaggaa
71400 ggctattctt tttttattga gacagggtct tgctctgtca cccaggctgg
agtacagtgg 71460 catgatcaca gctcattgca gcctcgacct ccctgggctc
agatgatctt cctacctcag 71520 cctcctgagt agcttggatt acaggaatgt
gccactatgc ctggctaatt tttgtagaga 71580 tgaggtttca ccatgttgcc
caggctggtc tctatctcct gagctcaagt gatctgcctg 71640 cctcggcctc
ccagtgctgg gtttgcaggc atgagccact gtgcccagtc aggatggcta 71700
ttcttatgat aaaggctaag atatttattc ttctttcccg ctttggaatt catatacctg
71760 agaactctat gattcaccct ctcactacta attttagaaa acaagctgtc
cttttccatt 71820 ccctcaaaaa caataggagt ccaagtaata aatgaacact
aggaagtcat agcatcatat 71880 gtaacatgtt tagcatcctc cctcctgaca
tggatgctgt tcacatgttc actgataagg 71940 agcctgagat tcagagaggt
tcagtggtgt gttcacatag ctgagactag aatccaggtc 72000 tcctaactct
cagtcttgcc ccctttctgc caatacagtg tctctcttgt atttctagat 72060
caaggcaaag aggacacttt gatagttctc cccacacttg tgtgtccatg attgtgtgtg
72120 tgtgtgtgtg tgtgtgtgtg tgtgtgtatg ttgtgggtgg ataatatgta
aatgcaagaa 72180 ctgtgatgta ctcaactcag ggtccagagg gtgctgcagt
gtggtgtttc tcaaagtgta 72240 tctatggctt gtcaggttag ggagagaagg
cagcactcgg gaccttgtcc atttattctg 72300 aaaggaatac atgtaaaata
gtcccatagg ggtgtcagaa agcttggcct taaggtcaaa 72360 agagcacacc
ctgaatacag gtttgcgcgt ttgctggtgt gtgagctaac aaatgccact 72420
ctcacacggt ttctttcagt cccactgtgg agcttccctg agggtgcccg ggcaagtctt
72480 gccagcaagg cagcaagact tcctgctatc caagcccatg gaggaaagtt
actgctgagg 72540 acccacccaa tggaaggatt cttctcagcc ttgaacctgg
agcactggga acaactggtc 72600 tcctgtgatg gctgggactc ctcgcgggag
gggactgcgc tgctatagct cttgctgcct 72660 ctcttgaata gctctaactc
caaacctctg tccacacctc cagagcacca agtccagatt 72720 tgtgtgtaag
cagctgggtg cctggggcct ctcgtgcaca ctggattggt ttctcagttg 72780
ctgggcgagc ctgtactctg cctgacgagg aacgctggct ccgaagaggc cctgtgtaga
72840 aggctgtcag ctgctcagcc tgctttgagc ctcagtgaga agtccttccg
acaggagctg 72900 actcatgtca ggatggcagg cctggtatct tgctcgggcc
ctagctgttg gggttctcat 72960 gggttgcact gaccatactg cttacgtctt
agccattccg tcctgctccc cagctcactc 73020 tctgaagcac acatcattgg
ctttcctatt tttctgttca ttttttaatt gagcaaatgt 73080 ctattgaaca
cttaaaatta attagaatgt ggtaatggac atattactga gcctctccat 73140
ttggaaccca gtggagttgg gatttctaga ccctctttct gtttggatgg tgtatgtgta
73200 tatgcatggg gaaaggcacc tggggcctgg gggaggctat aggatataag
cattagggac 73260 cctgaggctt taagtggttt ctatttcttc ttagttatta
tgtgccacct tcttagttat 73320 tatgtgccac ctcccctatg agtgacgtgt
ttgatcacta gcagaatagc aagcagagta 73380 tcattcatgc tggggccaga
atgatggccg gttgccagat ataactgctt tggagcaaat 73440 ctcttctgtt
tagagagata gaagttatga catatgtaat acacatctgt gtacacagaa 73500
accggcacct gccagacaga gctggttcta agatttaata cagtgctttt tttcctcttt
73560 gaaatatttt actttaatac cagtgccttt tcttgttgaa cttcttggaa
aagccaccaa 73620 ttctagatct tgatttgaat taatacacac aatatctgag
acacttacac ttttcaaaag 73680 atttgtgtat gcattgccta attagagtag
ggggagaagg gcaactatta ttatccctat 73740 tttacaaaac tgaggcttag
tgaggttcag ccacatgcct agacttatat actagttagt 73800 ggtgcagcca
gggagaggac tcagatttcc tggaggcaaa gtctatctct gaaactccat 73860
gaagactttt gcagccagtt cccaccaata tgccccagac gtgagacaaa caaggacttt
73920 tttttttata tagagccatc cataaaatcc taagcccttt tattaatgta
taaccaggag 73980 aacatctgtg ccaacggttg gactttttat ggctgagatt
cgggaggaag tgtgacacca 74040 agcaggagag gaagaatgat tttctttgta
cttaggtttt ctaaggacat tgttttaatc 74100 tgtatcgtgc caaagttgta
tcactgttaa acttctgaag acataaccag ttgagtctta 74160 tttcaagata
tgttctcaag ccaattgtgt gcttctcttg tttctgtgat tgctttctag 74220
ccaaagcgaa gcttgtacag gttgagtatc ccttatccaa aatgcttgga accagaagtg
74280 tttcaaattt tagattattt tcagattttg gaatgtttgc atatacataa
tgagatattt 74340 tgggaatagg acccgagcct aaacacaaaa ttcattgatg
tgtcagttac accttatcca 74400 catagcctga gggtaatttt atacgatatt
ttaaatagtt gtgtacatga agcatggttt 74460 gtggtaactt atgtgagggg
ttttcccatt ttttgtcttg ttggtgctca aaaagttttg 74520 gattttggag
catttcggat tttggatttt tggattaggg ttgctcaacc catattattg 74580
gctgtacatc ctggtcactt ctgacttctg tttttactaa tggaagcttt gcaaattgaa
74640 ttctcagtga gttgtatatt tatacacctg gcttgaagcc ttaattgtat
ataatgatgc 74700 tttttaaaaa atgctatttg gaagactatt tatttctcgt
gtatataatg tatataaaaa 74760 aatatggtta gtgtttacct aaggttaacc
aatttcaaga ttaaaatttt taaatagtaa 74820 aataataaaa aattataaag
ttcttaatgg tctgacaact caattttttt tttttttttt 74880 tttttttttg
agacagagcc tctctctgtc acccaggctg gagtgcagtg gcaatcttgg 74940
ctcactacaa cctctgcctc ctgggctcag gtggtcctcc cacctcagcc ttctgagtag
75000 ctgggattac agagatgcgt caccatgtct ggc 75033 <210> SEQ ID
NO 19 <400> SEQUENCE: 19 000 <210> SEQ ID NO 20
<211> LENGTH: 289 <212> TYPE: DNA <213> ORGANISM:
homo sapiens <220> FEATURE: <400> SEQUENCE: 20
cccatattat tggctgtaca tcctggtcac ttctgacttc tgtttttact aatggaagct
60 ttgcaaattg aattctcagt gagttgtata tttatacacc tggcttgaag
ccttaattgt 120 atataatgat actttttaaa aaatgctatt tggaagacta
tttatttctc gtgtatataa 180 tgtatataaa aaaatatggt tagtgtttac
ctaaggttaa ccaatttcaa gattaaaatt 240 tttaaatagt aaaataataa
aaaattataa aaaaaaaaaa aaaaaaaaa 289 <210> SEQ ID NO 21
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Antisense Oligonucleotide <400> SEQUENCE: 21
tcaacggctt gccccagaac 20 <210> SEQ ID NO 22 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 22 ggtggaaaat
gaaaacttgg 20 <210> SEQ ID NO 23 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 23 cccctcccaa gaaacagaag 20
<210> SEQ ID NO 24 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 24 ggagttgctc atcctgcccc 20 <210> SEQ
ID NO 25 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
25 ctctggacca aaaggtacgg 20 <210> SEQ ID NO 26 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 26 tgtggagctt
atcttccagc 20 <210> SEQ ID NO 27 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 27 ctcacagatg gtttgacctc 20
<210> SEQ ID NO 28 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 28 gacggagagg tagcatcctt 20 <210> SEQ
ID NO 29 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
29 cagggctgac acgagtttgt 20 <210> SEQ ID NO 30 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 30 attgaccgca
tccgtgtaaa 20 <210> SEQ ID NO 31 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 31 tccttctcct gcagccagtc 20
<210> SEQ ID NO 32 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 32 cgtccttctc ctgcagccag 20 <210> SEQ
ID NO 33 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
33 gtggacattc ccgagagaaa 20 <210> SEQ ID NO 34 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 34 ctccgaggct
gtagccgatc 20 <210> SEQ ID NO 35 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 35 aaacatgggc ccggcaggat 20
<210> SEQ ID NO 36 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 36 cagcctggct ggaagtcacc 20 <210> SEQ
ID NO 37 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
37 tcctgattca ccagagagtc 20 <210> SEQ ID NO 38 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 38 gcttgtcctg
attcaccaga 20 <210> SEQ ID NO 39 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 39 aaaactcggc ttgtcctgat 20
<210> SEQ ID NO 40 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 40 gcactggaag gcaaaactcg 20 <210> SEQ
ID NO 41 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
41 gaagcgattg gagtcagtgc 20 <210> SEQ ID NO 42 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 42 tgaaaggcat
gcctgcccgg 20 <210> SEQ ID NO 43 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 43 ctgataatgg taaactctga 20
<210> SEQ ID NO 44 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 44 ttcttgtaac tgaagacatg 20 <210> SEQ
ID NO 45 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
45 gacgtaaaag gtgggctcaa 20 <210> SEQ ID NO 46 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 46 gctccactat
ttccagtggc 20 <210> SEQ ID NO 47 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 47 gaaggtgttg gtggcattct 20
<210> SEQ ID NO 48 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 48 aggtctccca agtcctcctc 20 <210> SEQ
ID NO 49 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
49 aggccccctc ccaggtgagc 20 <210> SEQ ID NO 50 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 50 gtagctgcga
aactccttcc 20 <210> SEQ ID NO 51 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 51 gatattcagc tcccgtccgg 20
<210> SEQ ID NO 52 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 52 aaatgtcagt ttccgctggg 20 <210> SEQ
ID NO 53 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
53 tgttctcagg gtcttctgta 20 <210> SEQ ID NO 54 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 54 cacagtggga
ctggtttcgt 20 <210> SEQ ID NO 55 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 55 ggcaccctca gggaagctcc 20
<210> SEQ ID NO 56 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 56 ttgctgcctt gctggcaaga 20 <210> SEQ
ID NO 57 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
57 gtcctcagca gtaactttcc 20 <210> SEQ ID NO 58 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 58 acagaggttt
ggagttagag 20 <210> SEQ ID NO 59 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 59 ccaatccagt gtgcacgaga 20
<210> SEQ ID NO 60 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 60 gggcctcttc ggagccagcg 20 <210> SEQ
ID NO 61 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
61 caacccatga gaaccccaac 20 <210> SEQ ID NO 62 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 62 aggacggaat
ggctaagacg 20 <210> SEQ ID NO 63 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 63 caatagacat ttgctcaatt 20
<210> SEQ ID NO 64 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 64 atcccaactc cactgggttc 20 <210> SEQ
ID NO 65 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
65 aggtgccttt ccccatgcat 20 <210> SEQ ID NO 66 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 66 tgcttatatc
ctatagcctc 20 <210> SEQ ID NO 67 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 67 ccacttaaag cctcagggtc 20
<210> SEQ ID NO 68 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 68 tagtgatcaa acacgtcact 20 <210> SEQ
ID NO 69 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
69 acatatgtca taacttctat 20 <210> SEQ ID NO 70 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 70 caacaagaaa
aggcactggt 20 <210> SEQ ID NO 71 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 71 ttaattcaaa tcaagatcta 20
<210> SEQ ID NO 72 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 72 ctaattaggc aatgcataca 20 <210> SEQ
ID NO 73 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
73 ctcactaagc ctcagttttg 20 <210> SEQ ID NO 74 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 74 tggctgcacc
actaactagt 20 <210> SEQ ID NO 75 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 75 gactttgcct ccaggaaatc 20
<210> SEQ ID NO 76 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 76 ggctgcaaaa gtcttcatgg 20 <210> SEQ
ID NO 77 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
77 atggatggct ctatataaaa 20 <210> SEQ ID NO 78 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 78 taaaagggct
taggatttta 20 <210> SEQ ID NO 79 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 79 acagatgttc tcctggttat 20
<210> SEQ ID NO 80 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 80 ataaaaagtc caaccgttgg 20 <210> SEQ
ID NO 81 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
81 ctcccgaatc tcagccataa 20 <210> SEQ ID NO 82 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 82 ctctcctgct
tggtgtcaca 20 <210> SEQ ID NO 83 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 83 atcattcttc ctctcctgct 20
<210> SEQ ID NO 84 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 84 ggcacgatac agattaaaac 20 <210> SEQ
ID NO 85 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
85 gaagtttaac agtgatacaa 20 <210> SEQ ID NO 86 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 86 ttgaaataag
actcaactgg 20 <210> SEQ ID NO 87 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 87 ccaaaacttt ttgagcacca 20
<210> SEQ ID NO 88 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 88 agacctttta ctttttgcaa 20 <210> SEQ
ID NO 89 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
89 cctagcctgg gaacccaaac 20 <210> SEQ ID NO 90 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 90 ggatccaaac
ctgcagcaga 20 <210> SEQ ID NO 91 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 91 tgaaggttac ctctgaaagg 20
<210> SEQ ID NO 92 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 92 taatggtaaa ctgcagtgac 20 <210> SEQ
ID NO 93 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
93 aggcacttac ttccgctggg 20 <210> SEQ ID NO 94 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 94 gtcatagatg
acgaatgtaa 20 <210> SEQ ID NO 95 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 95 gaattctgcc agcagactgc 20
<210> SEQ ID NO 96 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 96 ttcttaagaa gattgggttt 20 <210> SEQ
ID NO 97 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
97 atatacaatt aaggcttcaa 20 <210> SEQ ID NO 98 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 98 agtatcatta
tatacaatta 20 <210> SEQ ID NO 99 <211> LENGTH: 2227
<212> TYPE: DNA <213> ORGANISM: Mus musculus
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (275)...(1777) <400> SEQUENCE: 99 cggcccgact
tcgcagcggc tctgggaaag gacaggtcgg gctgggcagc gtgtccctcc 60
acacgctcgc tttcccggtc accgctcgca gcgctaccaa ccttccaggt tctgccagct
120 gtccacccca tcaccttctg gccgacaccc ggcctgtcca cttctagtct
ctggaggttt 180 tagtggtttc aaaccaaacc aacccaaacc aacccaacaa
caaaaaagcc caaaccaaaa 240 acctgcttga gaggaggggg cgtggcgggg aagg atg
cga aac acg gtt ttc ctg 295 Met Arg Asn Thr Val Phe Leu 1 5 ctc ggc
ttt tgg agc gtc tat tgt tac ttc ccg gcg gga agt atc aca 343 Leu Gly
Phe Trp Ser Val Tyr Cys Tyr Phe Pro Ala Gly Ser Ile Thr 10 15 20
acc ttg cgt ccc cag ggg tcg ctg cga gat gag cat cat aaa ccc act 391
Thr Leu Arg Pro Gln Gly Ser Leu Arg Asp Glu His His Lys Pro Thr 25
30 35 gga gta cca gct acc gcc aga ccc tct gtg gct ttt aac atc cgc
act 439 Gly Val Pro Ala Thr Ala Arg Pro Ser Val Ala Phe Asn Ile Arg
Thr 40 45 50 55 tct aag gac cca gag cag gaa ggg tgt aat ctc tcc ctt
ggt gac agc 487 Ser Lys Asp Pro Glu Gln Glu Gly Cys Asn Leu Ser Leu
Gly Asp Ser 60 65 70 aaa ctc tta gaa aac tgt ggc ttc aac atg aca
gcc aaa acc ttc ttc 535 Lys Leu Leu Glu Asn Cys Gly Phe Asn Met Thr
Ala Lys Thr Phe Phe 75 80 85 atc att cat gga tgg acg atg agt ggc
atg ttt gag agc tgg ctg cat 583 Ile Ile His Gly Trp Thr Met Ser Gly
Met Phe Glu Ser Trp Leu His 90 95 100 aaa ctt gta tca gcc ctg cag
atg aga gag aaa gat gct aac gtc gtg 631 Lys Leu Val Ser Ala Leu Gln
Met Arg Glu Lys Asp Ala Asn Val Val 105 110 115 gtg gtt gac tgg ctg
ccc ctg gct cat cag ctg tac acg gat gca gtc 679 Val Val Asp Trp Leu
Pro Leu Ala His Gln Leu Tyr Thr Asp Ala Val 120 125 130 135 aat aac
acc agg gtg gtg gga cag aga gta gct ggg atg ctt gac tgg 727 Asn Asn
Thr Arg Val Val Gly Gln Arg Val Ala Gly Met Leu Asp Trp 140 145 150
ctg cag gag aag gaa gag ttc tct ctt ggg aac gtt cac ttg att ggc 775
Leu Gln Glu Lys Glu Glu Phe Ser Leu Gly Asn Val His Leu Ile Gly 155
160 165 tac agc ctt gga gca cac gtg gct gga tac gct ggc aac ttt gtg
aaa 823 Tyr Ser Leu Gly Ala His Val Ala Gly Tyr Ala Gly Asn Phe Val
Lys 170 175 180 gga aca gtg ggc agg atc act ggt ctg gat ccc gcg ggt
ccc atg ttt 871 Gly Thr Val Gly Arg Ile Thr Gly Leu Asp Pro Ala Gly
Pro Met Phe 185 190 195 gaa ggg gtg gac atc aac aga agg ctg tcc ccg
gac gat gca gac ttt 919 Glu Gly Val Asp Ile Asn Arg Arg Leu Ser Pro
Asp Asp Ala Asp Phe 200 205 210 215 gtg gat gtc ctg cat acc tac acg
ctg tcc ttt ggc ttg agc att ggg 967 Val Asp Val Leu His Thr Tyr Thr
Leu Ser Phe Gly Leu Ser Ile Gly 220 225 230 att cgg atg cct gtg ggt
cac att gac atc tat ccc aat ggc ggt gac 1015 Ile Arg Met Pro Val
Gly His Ile Asp Ile Tyr Pro Asn Gly Gly Asp 235 240 245 ttc cag cca
ggc tgt gga ttc aat gat gtc atc gga tct ttt gca tat 1063 Phe Gln
Pro Gly Cys Gly Phe Asn Asp Val Ile Gly Ser Phe Ala Tyr 250 255 260
gga aca atc tca gag atg gtg aaa tgc gag cac gag cga gcc gta cac
1111 Gly Thr Ile Ser Glu Met Val Lys Cys Glu His Glu Arg Ala Val
His 265 270 275 ctc ttt gtc gac tct ctg gtg aat cag gac aag ccc agc
ttt gcc ttc 1159 Leu Phe Val Asp Ser Leu Val Asn Gln Asp Lys Pro
Ser Phe Ala Phe 280 285 290 295 cag tgc aca gac tcc agc cgc ttc aaa
agg gga atc tgc ctc agc tgc 1207 Gln Cys Thr Asp Ser Ser Arg Phe
Lys Arg Gly Ile Cys Leu Ser Cys 300 305 310 cgg aag aac cgt tgt aat
aac att ggc tac aac gcc aag aaa atg aga 1255 Arg Lys Asn Arg Cys
Asn Asn Ile Gly Tyr Asn Ala Lys Lys Met Arg 315 320 325 aag aag agg
aat agc aaa atg tat tta aaa acc cgg gct ggc atg cct 1303 Lys Lys
Arg Asn Ser Lys Met Tyr Leu Lys Thr Arg Ala Gly Met Pro 330 335 340
ttc aaa gtt tac cat tac cag ctg aaa gtt cac atg ttc tct tac aat
1351 Phe Lys Val Tyr His Tyr Gln Leu Lys Val His Met Phe Ser Tyr
Asn 345 350 355 aac agt ggg gac acc cag ccc acc ctc tac att acc ctg
tat ggt agc 1399 Asn Ser Gly Asp Thr Gln Pro Thr Leu Tyr Ile Thr
Leu Tyr Gly Ser 360 365 370 375 aac gca gac tcc cag aac ctg ccc ttg
gaa ata gtg gag aag att gag 1447 Asn Ala Asp Ser Gln Asn Leu Pro
Leu Glu Ile Val Glu Lys Ile Glu 380 385 390 ctg aat gcc aca aac acc
ttc ctt gtc tac act gag gag gac ttg ggc 1495 Leu Asn Ala Thr Asn
Thr Phe Leu Val Tyr Thr Glu Glu Asp Leu Gly 395 400 405 gat ctc ttg
aag atg cga ctt acc tgg gag ggg gta gcc cat tcc tgg 1543 Asp Leu
Leu Lys Met Arg Leu Thr Trp Glu Gly Val Ala His Ser Trp 410 415 420
tgc aac ctg tgg aat gag ttt cgc aac tac ctg tct caa ccc agc aac
1591 Cys Asn Leu Trp Asn Glu Phe Arg Asn Tyr Leu Ser Gln Pro Ser
Asn 425 430 435 ccc tcg agg gag ctg tac atc cgg cga att cgt gtc aaa
tct ggg gaa 1639 Pro Ser Arg Glu Leu Tyr Ile Arg Arg Ile Arg Val
Lys Ser Gly Glu 440 445 450 455 acc cag cgc aaa gtg aca ttt tgc act
caa gac cca acg aag agt agc 1687 Thr Gln Arg Lys Val Thr Phe Cys
Thr Gln Asp Pro Thr Lys Ser Ser 460 465 470 atc tcc cct ggc cag gag
ctg tgg ttt cac aag tgt cag gat ggc tgg 1735 Ile Ser Pro Gly Gln
Glu Leu Trp Phe His Lys Cys Gln Asp Gly Trp 475 480 485 aaa atg aaa
aac aaa acc agt ccc ttt gtg aac ttg gcc tga 1777 Lys Met Lys Asn
Lys Thr Ser Pro Phe Val Asn Leu Ala * 490 495 500 gggcccaaga
agtcctggcg tccacaccca caccccactg tccacgcaca tggaggaaaa 1837
gttactgctg aagacccact cgatggacga tctcagcctt gagccccacg aggagcttgc
1897 ttgctgggct catcctgtct cccctgacaa ctgtgacttc tcctggagag
gcctgtgcac 1957 tgctgaagtt cttgctgatg attctagctg taaacctttg
ttgccgccgc aggaagctga 2017 ggccagcttg tgtgtgagca ctggagtgtc
cagagccctg cacactcggg gtggggggcg 2077 gggtactctc cctgtcgcta
ggtgagcact ggctttgtcc aacatcaggg aacacaaggc 2137 tctgaagtgg
ccctgtgtgg aaggttggca gctgcctggc ctcactgaac cttagtgaca 2197
agtctttgcc tcaggagctg actcatgccg 2227 <210> SEQ ID NO 100
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Antisense Oligonucleotide <400> SEQUENCE: 100
ttcccagagc cgctgcgaag 20 <210> SEQ ID NO 101 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 101 gaacctggaa
ggttggtagc 20 <210> SEQ ID NO 102 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 102 cctccagaga ctagaagtgg 20
<210> SEQ ID NO 103 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 103 actaaaacct ccagagacta 20 <210> SEQ
ID NO 104 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
104 cgtgtttcgc atccttcccc 20 <210> SEQ ID NO 105 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 105 aggttgtgat
acttcccgcc 20 <210> SEQ ID NO 106 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 106 tcatctcgca gcgacccctg 20
<210> SEQ ID NO 107 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 107 tggtactcca gtgggtttat 20 <210> SEQ
ID NO 108 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
108 tgcggatgtt aaaagccaca 20 <210> SEQ ID NO 109 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 109 gtcaccaagg
gagagattac 20 <210> SEQ ID NO 110 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 110 gccacagttt tctaagagtt 20
<210> SEQ ID NO 111 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 111 gttattgact gcatccgtgt 20 <210> SEQ
ID NO 112 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
112 accctggtgt tattgactgc 20 <210> SEQ ID NO 113 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 113 ccagtcaagc
atcccagcta 20 <210> SEQ ID NO 114 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 114 gttcccaaga gagaactctt 20
<210> SEQ ID NO 115 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 115 cacgtgtgct ccaaggctgt 20 <210> SEQ
ID NO 116 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
116 catccacaaa gtctgcatcg 20 <210> SEQ ID NO 117 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 117 caggacatcc
acaaagtctg 20 <210> SEQ ID NO 118 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 118 gtatgcagga catccacaaa 20
<210> SEQ ID NO 119 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 119 tgtaggtatg caggacatcc 20 <210> SEQ
ID NO 120 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
120 cagcgtgtag gtatgcagga 20 <210> SEQ ID NO 121 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 121 aaggacagcg
tgtaggtatg 20 <210> SEQ ID NO 122 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 122 agccaaagga cagcgtgtag 20
<210> SEQ ID NO 123 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 123 gctcaagcca aaggacagcg 20 <210> SEQ
ID NO 124 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
124 ccaatgctca agccaaagga 20 <210> SEQ ID NO 125 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 125 gaatcccaat
gctcaagcca 20 <210> SEQ ID NO 126 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 126 catccgaatc ccaatgctca 20
<210> SEQ ID NO 127 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 127 tagatgtcaa tgtgacccac 20 <210> SEQ
ID NO 128 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
128 tgggatagat gtcaatgtga 20 <210> SEQ ID NO 129 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 129 cgccattggg
atagatgtca 20 <210> SEQ ID NO 130 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 130 tttcaccatc tctgagattg 20
<210> SEQ ID NO 131 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 131 aaagaggtgt acggctcgct 20 <210> SEQ
ID NO 132 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
132 tcgacaaaga ggtgtacggc 20 <210> SEQ ID NO 133 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 133 gagagtcgac
aaagaggtgt 20 <210> SEQ ID NO 134 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 134 caccagagag tcgacaaaga 20
<210> SEQ ID NO 135 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 135 cagattcccc ttttgaagcg 20 <210> SEQ
ID NO 136 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
136 ccaatgttat tacaacggtt 20 <210> SEQ ID NO 137 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 137 tgtgaacttt
cagctggtaa 20 <210> SEQ ID NO 138 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 138 taagagaaca tgtgaacttt 20
<210> SEQ ID NO 139 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 139 cccactgtta ttgtaagaga 20 <210> SEQ
ID NO 140 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
140 atttccaagg gcaggttctg 20 <210> SEQ ID NO 141 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 141 gtgtagacaa
ggaaggtgtt 20 <210> SEQ ID NO 142 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 142 gagatcgccc aagtcctcct 20
<210> SEQ ID NO 143 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 143 gtaagtcgca tcttcaagag 20 <210> SEQ
ID NO 144 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
144 taccccctcc caggtaagtc 20 <210> SEQ ID NO 145 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 145 ggaatgggct
accccctccc 20 <210> SEQ ID NO 146 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 146 ctcattccac aggttgcacc 20
<210> SEQ ID NO 147 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 147 gggtttcccc agatttgaca 20 <210> SEQ
ID NO 148 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
148 cacttgtgaa accacagctc 20 <210> SEQ ID NO 149 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 149 aaagggactg
gttttgtttt 20 <210> SEQ ID NO 150 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 150 ttgggccctc aggccaagtt 20
<210> SEQ ID NO 151 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 151 ccagcaagca agctcctcgt 20 <210> SEQ
ID NO 152 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
152 tcagcaagaa cttcagcagt 20 <210> SEQ ID NO 153 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 153 caaaggttta
cagctagaat 20 <210> SEQ ID NO 154 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 154 cttcctgcgg cggcaacaaa 20
<210> SEQ ID NO 155 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 155 gctcacacac aagctggcct 20 <210> SEQ
ID NO 156 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
156 gggctctgga cactccagtg 20 <210> SEQ ID NO 157 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 157 gctcacctag
cgacagggag 20 <210> SEQ ID NO 158 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 158 gccttgtgtt ccctgatgtt 20
<210> SEQ ID NO 159 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 159 acacagggcc acttcagagc 20 <210> SEQ
ID NO 160 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
160 cttccacaca gggccacttc 20 <210> SEQ ID NO 161 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 161 ttcagtgagg
ccaggcagct 20 <210> SEQ ID NO 162 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 162 taaggttcag tgaggccagg 20
<210> SEQ ID NO 163 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 163 gacttgtcac taaggttcag 20 <210> SEQ
ID NO 164 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
164 aatagaacca ggatccatca 20 <210> SEQ ID NO 165 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 165 tctgctagag
atcaagggtg 20 <210> SEQ ID NO 166 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 166 gcgcagcagg tatgtagaac 20
<210> SEQ ID NO 167 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 167 tcaaactact aaagggtgtc 20 <210> SEQ
ID NO 168 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
168 ccaggaaacc ttgctgggtc 20 <210> SEQ ID NO 169 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 169 atggagttac
agaaaggatt 20 <210> SEQ ID NO 170 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 170 acagatgcaa agaatgtgcg 20
<210> SEQ ID NO 171 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 171 tataaagctg gtacaataca 20 <210> SEQ
ID NO 172 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
172 aaaactaacc atagatttgt 20 <210> SEQ ID NO 173 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 173 aaatcttgaa
atcggttaat 20 <210> SEQ ID NO 174 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 174 gttctggggc aagccgttga 20
<210> SEQ ID NO 175 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 175 gctggaagat aagctccaca 20 <210> SEQ
ID NO 176 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 176
gaggtcaaac catctgtgag 20 <210> SEQ ID NO 177 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 177 aaggatgcta
cctctccgtc 20 <210> SEQ ID NO 178 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 178 acaaactcgt gtcagccctg 20
<210> SEQ ID NO 179 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 179 tttacacgga tgcggtcaat 20 <210> SEQ
ID NO 180 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 180
gactggctgc aggagaagga 20 <210> SEQ ID NO 181 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 181 ctggctgcag
gagaaggacg 20 <210> SEQ ID NO 182 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 182 tttctctcgg gaatgtccac 20
<210> SEQ ID NO 183 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 183 gatcggctac agcctcggag 20 <210> SEQ
ID NO 184 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 184
atcctgccgg gcccatgttt 20 <210> SEQ ID NO 185 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 185 ggtgacttcc
agccaggctg 20 <210> SEQ ID NO 186 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 186 gactctctgg tgaatcagga 20
<210> SEQ ID NO 187 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 187 tctggtgaat caggacaagc 20 <210> SEQ
ID NO 188 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 188
atcaggacaa gccgagtttt 20 <210> SEQ ID NO 189 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 189 cgagttttgc
cttccagtgc 20 <210> SEQ ID NO 190 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 190 gcactgactc caatcgcttc 20
<210> SEQ ID NO 191 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 191 ccgggcaggc atgcctttca 20 <210> SEQ
ID NO 192 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 192
tcagagttta ccattatcag 20 <210> SEQ ID NO 193 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 193 catgtcttca
gttacaagaa 20 <210> SEQ ID NO 194 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 194 ttgagcccac cttttacgtc 20
<210> SEQ ID NO 195 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 195 gccactggaa atagtggagc 20 <210> SEQ
ID NO 196 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 196
agaatgccac caacaccttc 20 <210> SEQ ID NO 197 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 197 gaggaggact
tgggagacct 20 <210> SEQ ID NO 198 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 198 ccggacggga gctgaatatc 20
<210> SEQ ID NO 199 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 199 cccagcggaa actgacattt 20 <210> SEQ
ID NO 200 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 200
tacagaagac cctgagaaca 20 <210> SEQ ID NO 201 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 201 acgaaaccag
tcccactgtg 20 <210> SEQ ID NO 202 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 202 ggagcttccc tgagggtgcc 20
<210> SEQ ID NO 203 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 203 tcttgccagc aaggcagcaa 20 <210> SEQ
ID NO 204 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 204
ggaaagttac tgctgaggac 20 <210> SEQ ID NO 205 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 205 ctctaactcc
aaacctctgt 20 <210> SEQ ID NO 206 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 206 tctcgtgcac actggattgg 20
<210> SEQ ID NO 207 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 207 cgctggctcc gaagaggccc 20 <210> SEQ
ID NO 208 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 208
cgtcttagcc attccgtcct 20 <210> SEQ ID NO 209 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 209 aattgagcaa
atgtctattg 20 <210> SEQ ID NO 210 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 210 atgcatgggg aaaggcacct 20
<210> SEQ ID NO 211 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 211 gaggctatag gatataagca 20 <210> SEQ
ID NO 212 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 212
gaccctgagg ctttaagtgg 20 <210> SEQ ID NO 213 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 213 agtgacgtgt
ttgatcacta 20 <210> SEQ ID NO 214 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 214 atagaagtta tgacatatgt 20
<210> SEQ ID NO 215 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 215 accagtgcct tttcttgttg 20 <210> SEQ
ID NO 216 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 216
tgtatgcatt gcctaattag 20 <210> SEQ ID NO 217 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 217 caaaactgag
gcttagtgag 20 <210> SEQ ID NO 218 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 218 actagttagt ggtgcagcca 20
<210> SEQ ID NO 219 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 219 ccatgaagac ttttgcagcc 20 <210> SEQ
ID NO 220 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 220
taaaatccta agccctttta 20 <210> SEQ ID NO 221 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 221 ataaccagga
gaacatctgt 20 <210> SEQ ID NO 222 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 222 ccaacggttg gactttttat 20
<210> SEQ ID NO 223 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 223 ttatggctga gattcgggag 20 <210> SEQ
ID NO 224 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 224
tgtgacacca agcaggagag 20 <210> SEQ ID NO 225 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 225 agcaggagag
gaagaatgat 20 <210> SEQ ID NO 226 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 226 gttttaatct gtatcgtgcc 20
<210> SEQ ID NO 227 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 227 ttgtatcact gttaaacttc 20 <210> SEQ
ID NO 228 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 228
ccagttgagt cttatttcaa 20 <210> SEQ ID NO 229 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 229 tggtgctcaa
aaagttttgg 20 <210> SEQ ID NO 230 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 230 gtcactgcag tttaccatta 20
<210> SEQ ID NO 231 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 231 cccagcggaa gtaagtgcct 20 <210> SEQ
ID NO 232 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 232
ttacattcgt catctatgac 20 <210> SEQ ID NO 233 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 233 cttcgcagcg
gctctgggaa 20 <210> SEQ ID NO 234 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 234 gctaccaacc ttccaggttc 20
<210> SEQ ID NO 235 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 235 tagtctctgg aggttttagt 20 <210> SEQ
ID NO 236 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
236 ggggaaggat gcgaaacacg 20 <210> SEQ ID NO 237 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 237 ggcgggaagt
atcacaacct 20 <210> SEQ ID NO 238 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 238 ataaacccac tggagtacca 20
<210> SEQ ID NO 239 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 239 tgtggctttt aacatccgca 20 <210> SEQ
ID NO 240 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
240 gtaatctctc ccttggtgac 20 <210> SEQ ID NO 241 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 241 aactcttaga
aaactgtggc 20 <210> SEQ ID NO 242 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 242 acacggatgc agtcaataac 20
<210> SEQ ID NO 243 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 243 gcagtcaata acaccagggt 20 <210> SEQ
ID NO 244 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
244 tagctgggat gcttgactgg 20 <210> SEQ ID NO 245 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 245 acagccttgg
agcacacgtg 20 <210> SEQ ID NO 246 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 246 cgatgcagac tttgtggatg 20
<210> SEQ ID NO 247 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 247 tcctgcatac ctacacgctg 20 <210> SEQ
ID NO 248 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
248 ctacacgctg tcctttggct 20 <210> SEQ ID NO 249 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 249 cgctgtcctt
tggcttgagc 20 <210> SEQ ID NO 250 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 250 tcctttggct tgagcattgg 20
<210> SEQ ID NO 251 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 251 caatctcaga gatggtgaaa 20 <210> SEQ
ID NO 252 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
252 agcgagccgt acacctcttt 20 <210> SEQ ID NO 253 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 253 gccgtacacc
tctttgtcga 20 <210> SEQ ID NO 254 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 254 tctttgtcga ctctctggtg 20
<210> SEQ ID NO 255 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 255 cgcttcaaaa ggggaatctg 20 <210> SEQ
ID NO 256 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
256 aaccgttgta ataacattgg 20 <210> SEQ ID NO 257 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 257 ttaccagctg
aaagttcaca 20 <210> SEQ ID NO 258 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 258 aaagttcaca tgttctctta 20
<210> SEQ ID NO 259 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 259 tctcttacaa taacagtggg 20 <210> SEQ
ID NO 260 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
260 cagaacctgc ccttggaaat 20 <210> SEQ ID NO 261 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 261 aacaccttcc
ttgtctacac 20 <210> SEQ ID NO 262 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 262 aggaggactt gggcgatctc 20
<210> SEQ ID NO 263 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 263 ctcttgaaga tgcgacttac 20 <210> SEQ
ID NO 264 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
264 tgtcaaatct ggggaaaccc 20 <210> SEQ ID NO 265 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 265 gagctgtggt
ttcacaagtg 20 <210> SEQ ID NO 266 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 266 actgctgaag ttcttgctga 20
<210> SEQ ID NO 267 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 267 tttgttgccg ccgcaggaag 20 <210> SEQ
ID NO 268 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
268 ctccctgtcg ctaggtgagc 20 <210> SEQ ID NO 269 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 269 aacatcaggg
aacacaaggc 20 <210> SEQ ID NO 270 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 270 gctctgaagt ggccctgtgt 20
<210> SEQ ID NO 271 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 271 agctgcctgg cctcactgaa 20 <210> SEQ
ID NO 272 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
272 cctggcctca ctgaacctta 20 <210> SEQ ID NO 273 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 273 ctgaacctta
gtgacaagtc 20 <210> SEQ ID NO 274 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 274 cacccttgat ctctagcaga 20
<210> SEQ ID NO 275 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 275 gttctacata cctgctgcgc 20 <210> SEQ
ID NO 276 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
276 gacacccttt agtagtttga 20 <210> SEQ ID NO 277 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 277 gacccagcaa
ggtttcctgg 20 <210> SEQ ID NO 278 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 278 cgcacattct ttgcatctgt 20
<210> SEQ ID NO 279 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 279 tgtattgtac cagctttata 20 <210> SEQ
ID NO 280 <211> LENGTH: 19 <212> TYPE: RNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
280 cgagaggcgg acgggaccg 19 <210> SEQ ID NO 281 <211>
LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1)...(19) <223>
OTHER INFORMATION: bases at these positions are RNA <400>
SEQUENCE: 281 cgagaggcgg acgggaccgt t 21 <210> SEQ ID NO 282
<211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Antisense Oligonucleotide <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: 3, 4, 6,
8, 9, 10, 11, 12, 14, 15, 16, 17, 19, 20, 21 <223> OTHER
INFORMATION: bases at these positions are RNA <400> SEQUENCE:
282 ttgctctccg cctgccctgg c 21
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 282
<210> SEQ ID NO 1 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 1 tccgtcatcg ctcctcaggg 20 <210> SEQ ID
NO 2 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
2 gtgcgcgcga gcccgaaatc 20 <210> SEQ ID NO 3 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 3 atgcattctg
cccccaagga 20 <210> SEQ ID NO 4 <211> LENGTH: 3927
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (253)...(1755) <400> SEQUENCE: 4 agcagcgagt
ccttgcctcc cggcggctca ggacgagggc agatctcgtt ctggggcaag 60
ccgttgacac tcgctccctg ccaccgcccg ggctccgtgc cgccaagttt tcattttcca
120 ccttctctgc ctccagtccc ccagcccctg gccgagagaa gggtcttacc
ggccgggatt 180 gctggaaaca ccaagaggtg gtttttgttt tttaaaactt
ctgtttcttg ggagggggtg 240 tggcggggca gg atg agc aac tcc gtt cct ctg
ctc tgt ttc tgg agc ctc 291 Met Ser Asn Ser Val Pro Leu Leu Cys Phe
Trp Ser Leu 1 5 10 tgc tat tgc ttt gct gcg ggg agc ccc gta cct ttt
ggt cca gag gga 339 Cys Tyr Cys Phe Ala Ala Gly Ser Pro Val Pro Phe
Gly Pro Glu Gly 15 20 25 cgg ctg gaa gat aag ctc cac aaa ccc aaa
gct aca cag act gag gtc 387 Arg Leu Glu Asp Lys Leu His Lys Pro Lys
Ala Thr Gln Thr Glu Val 30 35 40 45 aaa cca tct gtg agg ttt aac ctc
cgc acc tcc aag gac cca gag cat 435 Lys Pro Ser Val Arg Phe Asn Leu
Arg Thr Ser Lys Asp Pro Glu His 50 55 60 gaa gga tgc tac ctc tcc
gtc ggc cac agc cag ccc tta gaa gac tgc 483 Glu Gly Cys Tyr Leu Ser
Val Gly His Ser Gln Pro Leu Glu Asp Cys 65 70 75 agt ttc aac atg
aca gct aaa acc ttt ttc atc att cac gga tgg acg 531 Ser Phe Asn Met
Thr Ala Lys Thr Phe Phe Ile Ile His Gly Trp Thr 80 85 90 atg agc
ggt atc ttt gaa aac tgg ctg cac aaa ctc gtg tca gcc ctg 579 Met Ser
Gly Ile Phe Glu Asn Trp Leu His Lys Leu Val Ser Ala Leu 95 100 105
cac aca aga gag aaa gac gcc aat gta gtt gtg gtt gac tgg ctc ccc 627
His Thr Arg Glu Lys Asp Ala Asn Val Val Val Val Asp Trp Leu Pro 110
115 120 125 ctg gcc cac cag ctt tac acg gat gcg gtc aat aat acc agg
gtg gtg 675 Leu Ala His Gln Leu Tyr Thr Asp Ala Val Asn Asn Thr Arg
Val Val 130 135 140 gga cac agc att gcc agg atg ctc gac tgg ctg cag
gag aag gac gat 723 Gly His Ser Ile Ala Arg Met Leu Asp Trp Leu Gln
Glu Lys Asp Asp 145 150 155 ttt tct ctc ggg aat gtc cac ttg atc ggc
tac agc ctc gga gcg cac 771 Phe Ser Leu Gly Asn Val His Leu Ile Gly
Tyr Ser Leu Gly Ala His 160 165 170 gtg gcc ggg tat gca ggc aac ttc
gtg aaa gga acg gtg ggc cga atc 819 Val Ala Gly Tyr Ala Gly Asn Phe
Val Lys Gly Thr Val Gly Arg Ile 175 180 185 aca ggt ttg gat cct gcc
ggg ccc atg ttt gaa ggg gcc gac atc cac 867 Thr Gly Leu Asp Pro Ala
Gly Pro Met Phe Glu Gly Ala Asp Ile His 190 195 200 205 aag agg ctc
tct ccg gac gat gca gat ttt gtg gat gtc ctc cac acc 915 Lys Arg Leu
Ser Pro Asp Asp Ala Asp Phe Val Asp Val Leu His Thr 210 215 220 tac
acg cgt tcc ttc ggc ttg agc att ggt att cag atg cct gtg ggc 963 Tyr
Thr Arg Ser Phe Gly Leu Ser Ile Gly Ile Gln Met Pro Val Gly 225 230
235 cac att gac atc tac ccc aat ggg ggt gac ttc cag cca ggc tgt gga
1011 His Ile Asp Ile Tyr Pro Asn Gly Gly Asp Phe Gln Pro Gly Cys
Gly 240 245 250 ctc aac gat gtc ttg gga tca att gca tat gga aca atc
aca gag gtg 1059 Leu Asn Asp Val Leu Gly Ser Ile Ala Tyr Gly Thr
Ile Thr Glu Val 255 260 265 gta aaa tgt gag cat gag cga gcc gtc cac
ctc ttt gtt gac tct ctg 1107 Val Lys Cys Glu His Glu Arg Ala Val
His Leu Phe Val Asp Ser Leu 270 275 280 285 gtg aat cag gac aag ccg
agt ttt gcc ttc cag tgc act gac tcc aat 1155 Val Asn Gln Asp Lys
Pro Ser Phe Ala Phe Gln Cys Thr Asp Ser Asn 290 295 300 cgc ttc aaa
aag ggg atc tgt ctg agc tgc cgc aag aac cgt tgt aat 1203 Arg Phe
Lys Lys Gly Ile Cys Leu Ser Cys Arg Lys Asn Arg Cys Asn 305 310 315
agc att ggc tac aat gcc aag aaa atg agg aac aag agg aac agc aaa
1251 Ser Ile Gly Tyr Asn Ala Lys Lys Met Arg Asn Lys Arg Asn Ser
Lys 320 325 330 atg tac cta aaa acc cgg gca ggc atg cct ttc aga gtt
tac cat tat 1299 Met Tyr Leu Lys Thr Arg Ala Gly Met Pro Phe Arg
Val Tyr His Tyr 335 340 345 cag atg aaa atc cat gtc ttc agt tac aag
aac atg gga gaa att gag 1347 Gln Met Lys Ile His Val Phe Ser Tyr
Lys Asn Met Gly Glu Ile Glu 350 355 360 365 ccc acc ttt tac gtc acc
ctt tat ggc act aat gca gat tcc cag act 1395 Pro Thr Phe Tyr Val
Thr Leu Tyr Gly Thr Asn Ala Asp Ser Gln Thr 370 375 380 ctg cca ctg
gaa ata gtg gag cgg atc gag cag aat gcc acc aac acc 1443 Leu Pro
Leu Glu Ile Val Glu Arg Ile Glu Gln Asn Ala Thr Asn Thr 385 390 395
ttc ctg gtc tac acc gag gag gac ttg gga gac ctc ttg aag atc cag
1491 Phe Leu Val Tyr Thr Glu Glu Asp Leu Gly Asp Leu Leu Lys Ile
Gln 400 405 410 ctc acc tgg gag ggg gcc tct cag tct tgg tac aac ctg
tgg aag gag 1539 Leu Thr Trp Glu Gly Ala Ser Gln Ser Trp Tyr Asn
Leu Trp Lys Glu 415 420 425 ttt cgc agc tac ctg tct caa ccc cgc aac
ccc gga cgg gag ctg aat 1587 Phe Arg Ser Tyr Leu Ser Gln Pro Arg
Asn Pro Gly Arg Glu Leu Asn 430 435 440 445 atc agg cgc atc cgg gtg
aag tct ggg gaa acc cag cgg aaa ctg aca 1635 Ile Arg Arg Ile Arg
Val Lys Ser Gly Glu Thr Gln Arg Lys Leu Thr 450 455 460 ttt tgt aca
gaa gac cct gag aac acc agc ata tcc cca ggc cgg gag 1683 Phe Cys
Thr Glu Asp Pro Glu Asn Thr Ser Ile Ser Pro Gly Arg Glu 465 470 475
ctc tgg ttt cgc aag tgt cgg gat ggc tgg agg atg aaa aac gaa acc
1731 Leu Trp Phe Arg Lys Cys Arg Asp Gly Trp Arg Met Lys Asn Glu
Thr 480 485 490 agt ccc act gtg gag ctt ccc tga gggtgcccgg
gcaagtcttg ccagcaaggc 1785 Ser Pro Thr Val Glu Leu Pro 495 500
agcaagactt cctgctatcc aagcccatgg aggaaagtta ctgctgagga cccacccaat
1845 ggaaggattc ttctcagcct tgaccctgga gcactgggaa caactggtct
cctgtgatgg 1905 ctgggactcc tcgcgggagg ggactgcgct gctatagctc
ttgctgcctc tcttgaatag 1965 ctctaactcc aaacctctgt ccacacctcc
agagcaccaa gtccagattt gtgtgtaagc 2025 agctgggtgc ctggggcctc
tcgtgcacac tggattggtt tctcagttgc tgggcgagcc 2085 tgtactctgc
ctgacgagga acgctggctc cgaagaggcc ctgtgtagaa ggctgtcagc 2145
tgctcagcct gctttgagcc tcagtgagaa gtccttccga caggagctga ctcatgtcag
2205 gatggcaggc ctggtatctt gctcgggccc tagctgttgg ggttctcatg
ggttgcactg 2265 accatactgc ttacgtctta gccattccgt cctgctcccc
agctcactct ctgaagcaca 2325 catcattggc tttcctattt ttctgttcat
tttttaattg agcaaatgtc tattgaacac 2385 ttaaaattaa ttagaatgtg
gtaatggaca tattactgag cctctccatt tggaacccag 2445 tggagttggg
atttctagac cctctttctg tttggatggt gtatgtgtat atgcatgggg 2505
aaaggcacct ggggcctggg ggaggctata ggatataagc attagggacc ctgaggcttt
2565 aagtggtttc tatttcttct tagttattat gtgccacctt cttagttatt
atgtgccacc 2625 tcccctatga gtgacgtgtt tgatcactag cagaatagca
agcagagtat cattcatgct 2685 ggggccagaa tgatggccgg ttgccagata
taactgcttt ggagcaaatc tcttctgttt 2745 agagagatag aagttatgac
atatgtaata cacatctgtg tacacagaaa ccggcacctg 2805 ccagacagag
ctggttctaa gatttaatac agtgcttttt ttcctctttg aaatatttta 2865
ctttaatacc agtgcctttt cttgttgaac ttcttggaaa agccaccaat tctagatctt
2925 gatttgaatt aatacacaca atatctgaga cacttacact tttcaaaaga
tttgtgtatg 2985 cattgcctaa ttagagtagg gggagaaggg caactattat
tatccctatt ttacaaaact 3045 gaggcttagt gaggttcagc cacatgccta
gacttatata ctagttagtg gtgcagccag 3105 ggagaggact cagatttcct
ggaggcaaag tctatctctg aaactccatg aagacttttg 3165 cagccagttc
ccaccaatat gccccagacg tgagacaaac aaggactttt ttttttatat 3225
agagccatcc ataaaatcct aagccctttt attaatgtat aaccaggaga acatctgtgc
3285 caacggttgg actttttatg gctgagattc gggaggaagt gtgacaccaa
gcaggagagg 3345 aagaatgatt ttctttgtac ttaggttttc taaggacatt
gttttaatct gtatcgtgcc 3405 aaagttgtat cactgttaaa cttctgaaga
cataaccagt tgagtcttat ttcaagatat 3465 gttctcaagc caattgtgtg
cttctcttgt ttctgtgatt gctttctagc caaagcgaag 3525 cttgtacagg
ttgagtatcc cttatccaaa atgcttggaa ccagaagtgt ttcaaatttt 3585
agattatttt cagattttgg aatgtttgca tatacataat gagatatttt gggaatagga
3645
cccgagccta aacacaaaat tcattgatgt gtcagttaca ccttatccac atagcctgag
3705 ggtaatttta tacgatattt taaatagttg tgtacatgaa gcatggtttg
tggtaactta 3765 tgtgaggggt tttcccattt tttgtcttgt tggtgctcaa
aaagttttgg attttggagc 3825 atttcggatt ttggattttt ggattagggt
tgctcaaccc atattattgg ctgtacatcc 3885 tggtcacttc tgacttctgt
ttttactaat ggaagctttg ca 3927 <210> SEQ ID NO 5 <211>
LENGTH: 19 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: PCR
Primer <400> SEQUENCE: 5 ccggacggga gctgaatat 19 <210>
SEQ ID NO 6 <211> LENGTH: 19 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR Primer <400> SEQUENCE: 6
cagtttccgc tgggtttcc 19 <210> SEQ ID NO 7 <211> LENGTH:
20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR Probe
<400> SEQUENCE: 7 aggcgcatcc gggtgaagtc 20 <210> SEQ ID
NO 8 <211> LENGTH: 19 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR Primer <400> SEQUENCE: 8 gaaggtgaag
gtcggagtc 19 <210> SEQ ID NO 9 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR Primer
<400> SEQUENCE: 9 gaagatggtg atgggatttc 20 <210> SEQ ID
NO 10 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR Probe <400> SEQUENCE: 10 caagcttccc
gttctcagcc 20 <210> SEQ ID NO 11 <211> LENGTH: 3610
<212> TYPE: DNA <213> ORGANISM: Mus musculus
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (144)...(1646) <400> SEQUENCE: 11 ccacgcgtcc
gcgacacccg gcctgtccac ttctagtctc tggaggtttt agtggtttca 60
aaccaaacca acccaaacca acccaacaac aaaaaagccc aaaccaaaaa cctgcttgag
120 aggagggggc gtggcgggga agg atg cga aac acg gtt ttc ctg ctc ggc
ttt 173 Met Arg Asn Thr Val Phe Leu Leu Gly Phe 1 5 10 tgg agc gtc
tat tgt tac ttc ccg gcg gga agt atc aca acc ttg cgt 221 Trp Ser Val
Tyr Cys Tyr Phe Pro Ala Gly Ser Ile Thr Thr Leu Arg 15 20 25 ccc
gag ggg tcg ctg cga gat gag cat cat aaa ccc act gga gta cca 269 Pro
Glu Gly Ser Leu Arg Asp Glu His His Lys Pro Thr Gly Val Pro 30 35
40 gct acc gcc aga ccc tct gtg gct ttt aac atc cgc act tct aag gac
317 Ala Thr Ala Arg Pro Ser Val Ala Phe Asn Ile Arg Thr Ser Lys Asp
45 50 55 cca gag cag gaa ggg tgt aat ctc tcc ctt ggt gac agc aaa
ctc tta 365 Pro Glu Gln Glu Gly Cys Asn Leu Ser Leu Gly Asp Ser Lys
Leu Leu 60 65 70 gaa aac tgt ggc ttc aac atg aca gcc aaa acc ttc
ttc atc att cat 413 Glu Asn Cys Gly Phe Asn Met Thr Ala Lys Thr Phe
Phe Ile Ile His 75 80 85 90 gga tgg acg atg agt ggc atg ttt gag agc
tgg ctg cat aaa ctt gta 461 Gly Trp Thr Met Ser Gly Met Phe Glu Ser
Trp Leu His Lys Leu Val 95 100 105 tca gcc ctg cag atg aga gag aaa
gat gct aac gtc gtg gtg gtt gac 509 Ser Ala Leu Gln Met Arg Glu Lys
Asp Ala Asn Val Val Val Val Asp 110 115 120 tgg ctg ccc ctg gct cat
cag ctg tac acg gat gca gtc aat aac acc 557 Trp Leu Pro Leu Ala His
Gln Leu Tyr Thr Asp Ala Val Asn Asn Thr 125 130 135 agg gtg gtg gga
cag aga gta gct ggg atg ctt gac tgg ctg cag gag 605 Arg Val Val Gly
Gln Arg Val Ala Gly Met Leu Asp Trp Leu Gln Glu 140 145 150 aag gaa
gag ttc tct ctt ggg aac gtt cac ttg att ggc tac agc ctt 653 Lys Glu
Glu Phe Ser Leu Gly Asn Val His Leu Ile Gly Tyr Ser Leu 155 160 165
170 gga gca cac gtg gct gga tac gct ggc aac ttt gtg aaa gga aca gtg
701 Gly Ala His Val Ala Gly Tyr Ala Gly Asn Phe Val Lys Gly Thr Val
175 180 185 ggc agg atc act ggt ctg gat ccc gcg ggt ccc atg ttt gaa
ggg gtg 749 Gly Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Met Phe Glu
Gly Val 190 195 200 gac atc aac aga agg ctg tcc ccg gac gat gca gac
ttt gtg gat gtc 797 Asp Ile Asn Arg Arg Leu Ser Pro Asp Asp Ala Asp
Phe Val Asp Val 205 210 215 ctg cat acc tac acg ctg tcc ttt ggc ttg
agc att ggg att cgg atg 845 Leu His Thr Tyr Thr Leu Ser Phe Gly Leu
Ser Ile Gly Ile Arg Met 220 225 230 cct gtg ggt cac att gac atc tat
ccc aat ggc ggt gac ttc cag cca 893 Pro Val Gly His Ile Asp Ile Tyr
Pro Asn Gly Gly Asp Phe Gln Pro 235 240 245 250 ggc tgt gga ttc aat
gat gtc atc gga tct ttt gca tat gga aca atc 941 Gly Cys Gly Phe Asn
Asp Val Ile Gly Ser Phe Ala Tyr Gly Thr Ile 255 260 265 tca gag atg
gtg aaa tgc gag cac gag cga gcc gta cac ctc ttt gtc 989 Ser Glu Met
Val Lys Cys Glu His Glu Arg Ala Val His Leu Phe Val 270 275 280 gac
tct ctg gtg aat cag gac aag ccc agc ttt gcc ttc cag tgc aca 1037
Asp Ser Leu Val Asn Gln Asp Lys Pro Ser Phe Ala Phe Gln Cys Thr 285
290 295 gac tcc agc cgc ttc aaa agg gga atc tgc ctc agc tgc cgg aag
aac 1085 Asp Ser Ser Arg Phe Lys Arg Gly Ile Cys Leu Ser Cys Arg
Lys Asn 300 305 310 cgt tgt aat aac att ggc tac aac gcc aag aaa atg
aga aag aag agg 1133 Arg Cys Asn Asn Ile Gly Tyr Asn Ala Lys Lys
Met Arg Lys Lys Arg 315 320 325 330 aat agc aaa atg tat tta aaa acc
cgg gct ggc atg cct ttc aaa gtt 1181 Asn Ser Lys Met Tyr Leu Lys
Thr Arg Ala Gly Met Pro Phe Lys Val 335 340 345 tac cat tac cag ctg
aaa gtt cac atg ttc tct tac aat aac agt ggg 1229 Tyr His Tyr Gln
Leu Lys Val His Met Phe Ser Tyr Asn Asn Ser Gly 350 355 360 gac acc
cag ccc acc ctc tac att acc ctg tat ggt agc aac gca gac 1277 Asp
Thr Gln Pro Thr Leu Tyr Ile Thr Leu Tyr Gly Ser Asn Ala Asp 365 370
375 tcc cag aac ctg ccc ttg gaa ata gtg gag aag att gag ctg aat gcc
1325 Ser Gln Asn Leu Pro Leu Glu Ile Val Glu Lys Ile Glu Leu Asn
Ala 380 385 390 aca aac acc ttc ctt gtc tac act gag gag gac ttg ggc
gat ctc ttg 1373 Thr Asn Thr Phe Leu Val Tyr Thr Glu Glu Asp Leu
Gly Asp Leu Leu 395 400 405 410 aag atg cga ctt acc tgg gag ggg gta
gcc cat tcc tgg tac aac ctg 1421 Lys Met Arg Leu Thr Trp Glu Gly
Val Ala His Ser Trp Tyr Asn Leu 415 420 425 tgg aat gag ttt cgc aac
tac ctg tct caa ccc agc aac ccc tcg agg 1469 Trp Asn Glu Phe Arg
Asn Tyr Leu Ser Gln Pro Ser Asn Pro Ser Arg 430 435 440 gag ctg tac
atc cgg cga att cgt gtc aaa tct ggg gaa acc cag cgc 1517 Glu Leu
Tyr Ile Arg Arg Ile Arg Val Lys Ser Gly Glu Thr Gln Arg 445 450 455
aaa gtg aca ttt tgc act caa gac cca acg aag agt agc atc tcc cct
1565 Lys Val Thr Phe Cys Thr Gln Asp Pro Thr Lys Ser Ser Ile Ser
Pro 460 465 470 ggc cag gag ctg tgg ttt cac aag tgt cag gat ggc tgg
aaa atg aaa 1613 Gly Gln Glu Leu Trp Phe His Lys Cys Gln Asp Gly
Trp Lys Met Lys 475 480 485 490 aac aaa acc agt ccc ttt gtg aac ttg
gcc tga gggcccaaga agtcctggcg 1666 Asn Lys Thr Ser Pro Phe Val Asn
Leu Ala * 495 500 tccacaccca caccccactg tccacgcaca tggaggaaaa
gttactgctg aagacccact 1726 cgatggacga tctcagcctt gagccccacg
aggagcttgc ttgctgggct catcctgtct 1786 cccctgacaa ctgtgacttc
tcctggagag gcctgtgcac tgctgaagtt cttgctgatg 1846 attctagctg
taaacctttg ttgccgccgc aggaagctga ggccagcttg tgtgtgagca 1906
ctggagtgtc cagagccctg cacactcggg gtggggggcg gggtactctc cctgtcgcta
1966 ggtgagcact ggctttgtcc aacatcaggg aacacaaggc tctgaagtgg
ccctgtgtgg 2026 aaggttggca gctgcctggc ctcactgaac cttagtgaca
agtctttgcc tcaggagctg 2086 actcatgcca tagagagggg actgtagacc
aggctggggc tgctgccctc ccacacgagg 2146 tactgatgga tcctggttct
attctgggta tttcatcctg ccttccagag caccttctga 2206 agttcacatc
gttggcattt cctttttatg ttatgcatac tttggctgaa caaacattta 2266
ttgggcactt cagctcatta gcaccaggca tgtatagaca catgactcaa cttcagcatt
2326 tggagccagc gagaccagga tccctggaat ctctcaagtt cactggcccc
tgagaatgcc 2386 tgtgttagtt aaagacagat gggatcaagg cgagggctac
aggctgagag agcttgagct 2446
cagaggcttt tatgaaccgt ttcctctgag ggccaccctt gatctctagc agaacagcaa
2506 gcagaacacc gtgcatgctg gccacagcag tggagccaag tctctgctgg
ttacggagct 2566 atacggtact gcaggagttc tacatacctg ctgcgcagag
accagccccg tggacagagc 2626 tggcatgatg gttgctacag tgctctttct
cccatgaagt ctttgctttt atatcagtgc 2686 cttatctgtt aagctcctgg
aggaaagccc cctattctag atctttatgt gaatggataa 2746 atgtgacacc
cgagacaccc tttagtagtt tgacagcttg cgtgtgtgcc gcctaattag 2806
agcacaggga gcagggcagc tgttattcct gttttaccaa gtcaaggctt agggaagttc
2866 agccacctgc ttagatgata tatcaaggtg gcagtggaag ggggtgagct
aaggacccag 2926 caaggtttcc tggaggcaaa gtttatgaaa tcctttctgt
aactccataa agatgtctgc 2986 agctatttcc tacccagatg ttcctgatgt
gataagcagg ggactttttt ttttttcctt 3046 cagatgctat ccataaaatc
caagcccttt cttaagatac aagcagaaga acggttgcgt 3106 ttttgtgggt
gtgctgtcag cctggggggt ggggggtggg gggtgggaga gcgattactc 3166
tgtgtttagg tttgtcacgc acattctttg catctgtatt gtaccagctt tatagcactg
3226 tttcatgcca aagttctgat gacgtaacca gttgaccctt cacacagagt
gccctttccc 3286 cccctccccc ctccccatgc ttctgtgatt gctctgtagc
catgtgaagc ttgctagccg 3346 cggctgtaca tcctgtgact tccaccttgg
gtttagtaat gggagcttga gattggagag 3406 ctgagtcctc tgtgggttct
gtatttatcc atttggcttg aagctttgtt tatatatcgg 3466 ctgctttttt
ttttttaaat gctcagacca ttatttattt cttgagtgta tataagtata 3526
aagacaaatc tatggttagt ttttacttta agattaaccg atttcaagat ttacaaaaaa
3586 aaacaacaaa aaaaaaaaaa aaaa 3610 <210> SEQ ID NO 12
<211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: PCR Primer <400> SEQUENCE: 12 gctgaatgcc
acaaacacct t 21 <210> SEQ ID NO 13 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR Primer
<400> SEQUENCE: 13 caggtaagtc gcatcttcaa gaga 24 <210>
SEQ ID NO 14 <211> LENGTH: 28 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: PCR Probe <400> SEQUENCE: 14
cttgtctaca ctgaggagga cttgggcg 28 <210> SEQ ID NO 15
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: PCR Primer <400> SEQUENCE: 15 ggcaaattca
acggcacagt 20 <210> SEQ ID NO 16 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: PCR Primer
<400> SEQUENCE: 16 gggtctcgct cctggaagat 20 <210> SEQ
ID NO 17 <211> LENGTH: 27 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: PCR Probe <400> SEQUENCE: 17 aaggccgaga
atgggaagct tgtcatc 27 <210> SEQ ID NO 18 <211> LENGTH:
75033 <212> TYPE: DNA <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(75033) <223> OTHER INFORMATION: n = A,T,C or
G <400> SEQUENCE: 18 agagagtgtg gctttgagcc ttggagagga
tgctctcctt ctccagggat cgcctcccca 60 gcggacgcag agtttcaggg
aaatgtccgc ctccgccact tgggatggca gtggggagag 120 gaggatctgg
gtgtccggag gagggcagtg ggagaaagct ggagctgctg gagtcgcagc 180
tgcctgcgga gcgggcccgg gaggaagcgg ggccgagcgt gcggcgtcca cgcggtgagt
240 gtgcagcgct ttcattcaaa ctttctccag tctcggttcc ggcgtcagca
aggtgtgacc 300 aatcagagcc cagagacggg aataaattat gcaaatcacc
atctggcgat gggtcagatg 360 actcccatac ttttaaaaac tacctctata
ggagcgtgac agcagcgagt ccttgcctcc 420 cggcggctca ggacgagggc
agatctcgtt ctggggcaag ccgttgacac tcgctccctg 480 ccaccgcccg
ggctccgtgc cgccaagttt tcattttcca ccttctctgc ctccagtccc 540
ccagcccctg gccgagagaa gggtcttacc ggccgggatt gctggaaaca ccaagaggtg
600 gtttttgttt tttaaaactt ctgtttcttg ggagggggtg tggcggggca
ggatgagcaa 660 ctccgttcct ctgctctgtt tctggagcct ctgctattgc
tttgctgcgg ggagccccgt 720 accttttggt ccagagggac ggctggaagg
taacgtgaat ttgtttttat tccccccagc 780 cacttctctg tgctgggtcc
cctctgtctt gctgattctt caaaccctcc ttgttcctat 840 gaaattcttc
ctttcccact gcgctgcccn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
960 nnnnnnnnng gccgcagtgc gctgtgaatg agccactgca ctccagcctg
ggcaacagag 1020 agattccatc taagaaaaaa gttcatttaa gttttatagg
aaaatcactg aaggttcaaa 1080 agacaaacta ttcactcaaa aggaaatgat
ctcacaaggc ttaaatgtct tctaatctaa 1140 cccaatgctg gctgacagac
tcaaatgtgg tgtgactgtt tttaattata ggcttgattt 1200 ctccctaaaa
tcagagaaaa tatggttgga gtccataggg gatggagaaa gaagggataa 1260
aagatgagga aggcaaaggc cagatcatgg aaggctctta tatcatcccc aaatatttgg
1320 aacaggggcc acaggaaaaa aaaaacccaa aaaatgacat gatcattctg
acagccattt 1380 tagaaaaatg actctgtcag ggccaggcgt ggtggctcac
gtctgtaatc ccagcacttt 1440 gggaggctga ggtgggcgga tcacatgagg
tcaggagttc aagaccagcc tggccaacat 1500 gacaaaatcc tatctctatt
aaaaatacaa aaattagctg ggcatcgtgg tgggtgcctg 1560 taatcccagc
tgcttgggag gctgaggcag gagaatcgct tgaacctgga ggcagaggtt 1620
gcagtgagct gagatcacac cactgcactc cagcctgggg ccacagagtg agaccttgtc
1680 tcaaaaaaaa aaaaaaaaag aaagaaagaa agaaagaaaa agaaaagaaa
agaaaaatga 1740 ctgtcaggaa tatggaggat atattaaagt gcagaaataa
ttagggcaag aagaccactt 1800 aaaagaataa tccagatttt gttaaataat
tgtatgtgca aagacaagaa gaggggagtc 1860 tctcatcttt ctggtttaag
atcctaggtg tatggggaag tcgccaaaca aggaagggag 1920 aaaggcaggg
tcgcctaggg atgcagagct tggtcacaga aggctgcctt ggatcccagg 1980
gctgccactc ccagctgccg gaccttggat ttgccgggga gttccttttt tttcttcttc
2040 tttttaacac attgtagcag ccagatcaac ttcatcattt acaaatagtt
gtcctaagga 2100 ttacttgagg aaatgcatgt aaaaacactg aaaatactgc
ctagaatcta gtaagcttat 2160 agaatcattg tctgttactc ttgtcaccat
gcaacataaa agaggaaccc ggaggagaag 2220 acaaagagtt ctgtttaagg
gcatgttagg tttcaaataa cctcaggtct tcagggacct 2280 cccagaaagg
atgtccaggg agtagtttgc tatcagggtc tagctcagga gacagatgtg 2340
gcgctggggt attaatctgg gagttagcat gcagttgaaa gctcatgtga ggggagggaa
2400 ttaccgagga aacaccatgg aatccagcat cagcaatgga agtggagtcg
aggggagaga 2460 cttagggctg aggtctccta cactgaggtc aaggaagcaa
gtgagcctag cctggagtct 2520 actctcctag agtttgagct gcctagaagg
gtggtgccat gaaatagaag ccctaacaaa 2580 agctaagtgc atcactgact
atgagggaat aaccagagag atgacctggg gaaggaaaaa 2640 agggaagaaa
atgccaaaag gttttctcct ccagatgaag atctagaagc agcggggaaa 2700
acgaggatat tgaaccagac ccttcagtta gcgcattttt cacacaggtt ataatacaat
2760 tgattggatg acattcccat cctgagaatt tcctgattac cataattacg
tctcatcctt 2820 tcatcttttt aattggccat ttacaaacca ctttcaggag
tacagggcca cataatcaaa 2880 cctaactaat gtgacgaata aataaaatgt
ttctttcata tctaataata cgtagcctgt 2940 cctagaacta caaacctgtt
tttaattgac tgacatttaa aaccctgaat ttttatttct 3000 gtatacaaaa
aagagaactt tgagacagtc cctaagtagg caattcgttt tcacacgttc 3060
ttaaaacata ttccacactc ccttcgcttt ccgccttcct gcctcctcag atctcgtttc
3120 ttcggctacg aatctcgcga gaagtcaagt tctcatgagt tctcccaaaa
tccaccgctc 3180 ttcctctttc cctaagcagc ctgaggtgag tgtttctcct
gcgttgctcc gagggcccaa 3240 tcctcctgcc atcgccgcca tcctggcttc
gggggcgccg gcctccaggc ccccgggagg 3300 agaactccta gggctactaa
atcctcgctg gaggcggtgg cttcttatgc gggaggacgt 3360 ggcggagggc
ctgactttgg gagccggggt cagtcggcct ctgaggtccg cagagggacg 3420
tgatgggcgg gaatggggac taccgggctc ctccactggt gggggcgccg gcccgccgtg
3480 gggtgcgggc cgcctggggt ccgtgcggac tccggaggtc cggtgtctag
tggtgagtgg 3540 tggccgcaac gaggaaaaag ttttggggga aagaaaagtc
gggtggaggc gtaacacgtt 3600 actacaagag tgttgcgtac aggagggctc
ttaaagtggg tcatagcccg aaggtgttga 3660 gagagacggc actcactacc
tgcagccctg acagcaaagg ggtttctgta gagcgggagg 3720 gaggaggtgt
agagggttac ggttgagttg tgccctgcgg atgcgtcgag tcattttacg 3780
cctggaagat ccagcattgg attgaaacag gctgtatttt cttccaaagg gttgactgga
3840 ttggtgaggc ccgtgtggct acttctgtgg aagcagtgct gtagttactg
gaagataaaa 3900 gggaaagcaa gcccttggtg ggggaaagta tggctgcgat
gatggcattt cttaggacac 3960 ctttggatta ataatgaaaa caactactct
ctgagcagct gttcgaatca tctgatattt 4020 atactgaatg agttactgta
agtacgtatt gacagaatta cactgtactt tcctctaggt 4080 gatctgtgaa
aatggttcgc tattcacttg acccggagaa ccccacgaaa tgtaagtgga 4140
caggaggtag atacccattt cctacttggg gcttggcata agataccaaa aattaaccaa
4200 aacgttttat ttcctagcat gcaaatcaag aggttccaat cttcgtgttc
actttaaggt 4260 atgcgattca tagttgtgat ccaacagttc ctcatgttcc
actcaaaaaa ggtagctgca 4320 gtgatgactt tcttaggaca cctttggatt
taccgtgaaa attaataaat tctgagcagc 4380 caccttatat ttaggcattg
atgatcaggg tgtaaggatg tagcgtttgt gaaattgaga 4440 agtagtacca
gaaaaccatt tgaaaaccta gtgtgcagat caagatgggg cattttaatt 4500
gtaattacat gatgatggaa tttaaacgtt ttatagtgaa taaatggagt tttggagttt
4560 tctctagctt caacgaagtt tacctggctt ttagtcacaa gtttttttaa
ttgccttgcc 4620 cccaaagaat agaaataact cgacattttg aaaagctgaa
aattgaaaat ttaacgttta 4680 ctttaaaaat taaagctttg atctagttaa
ccaacacttt attcttcata cttagaacac 4740 tcgtgaaact gctcaggcca
tcaagggtat gcatatacga aaagccacga agtatctgaa 4800 agatgtcact
ttacagaaac agtgtgtacc attccgacgt tacaatggtg gagttggcag 4860
gtgtgcgcag gtgagaattc ttagttgcca tttgaaaaga cagattttaa tggaaaagtg
4920 atgggatagg ataagaatgg ctaagatctg tgctgatgaa cctatttctg
gttgctgtaa 4980 tgacaggaca ccttggattg atggtgaaat aaaccatatc
ctaagaaacc gtgatatcag 5040 ataaattcat cttggctgta atgttaattt
aaatcaagga aaatgactca tcatctccat 5100 tttctttcag gcaagcaatg
gggctggaca caaggtcggt ggcccaaaaa gagtgctgaa 5160 ttattgctgc
acatgcttaa aaacgcagag agtaatgctg aacttaaggt acccaaacca 5220
ctaacatcct gtgcaacttg ggtggttgtt taattaatgt tggctgttca gatttatgtc
5280 cttgattttc ttgttttcag taattaactc atttaggatt ttttaaattt
ctacctgcag 5340 tttccacaga atgaaactat ttccttttat tttttttgag
tccctttatg gcaaaattct 5400 gtgaagatcc agaagcgtgc tctgtggtct
ctttaagcct aacacttagt atttctagtt 5460 ttctgctgtc tttttacact
ggaggtactt taccaggggc ttttacccct ttttgtgaca 5520 tacacctttg
gtagtatgat taattatcaa aatgattgcc ttagcagtga ttaatgtggt 5580
ttgtggccta ccttcataat ggagagtcat gttgcatttc agaaagaaat tgtttaaaat
5640 ttcaaaaagt ttaaacaatg acaaacttgt gttgacaaaa cacaaatttc
tccattttgt 5700 atattaccca ttagcctttt gcatttgaag gtctgggcca
gaactggaat tagtttaggt 5760 ctgtatggct ccaaaccttc taagccatgc
tgagaaattt tatcatcaag acttcaaatt 5820 gggttcttcc ttacccctca
gctctccacc cgtctaagga tctttgggaa ggccactcat 5880 agacaaaatg
tatagcacac tgagtttggt ggcaatttag acatgtaaag gtgaaggcag 5940
acaactggtt aaaaaaatgc tatttgcaga ataaaaggat tgcctttcaa aaatgatttc
6000 attgaggcag gactctggag caagcctggg aattcatatt tagcaatgat
agtttgtggt 6060 gttttactaa ttaaggatgt tcctggtttc attctccttc
ctttcttccc cagggtttag 6120 atgtagattc tctggtcatt gagcatatcc
aagtgaacaa agcacctaag atgcgccgcc 6180 ggacctacag agctcatggt
cggattaacc catacatgag ctctccctgc cacattgaga 6240 tgatccttac
ggaaaaggaa cagattgttc ctaaaccaga agaggaggtt gcccagaaga 6300
aaaaggtaaa taagtagttg ctcggttttg tttgtgatag tagaaagatt tgtggttgct
6360 gtgatgacta tcttaggaca cctttggaat aactatgaaa gaaaactatt
ctgagcaacc 6420 cttttcacct gtcttatttt ggcttttgta agtttgtttc
ttgactaata ataaatggta 6480 agttttctgt aatcccagca ctttgggagg
ctgaggtggg tggatcacaa ggtcaggaga 6540 tcgagaccat cctggctaac
acagtgaaac cccgtctcta ctaaaaatgc aaaaaaaaat 6600 tagctgggcg
tggtggcggg tatctgtagt cccagctact caggaggctg aggcaggaga 6660
atggcatgaa cccgggagga ggaactagga gtgagccgag atcgcgccac tgcactccag
6720 cctgggtgac agagcgagac gctgtctcaa aaaaaaaaaa aactggtagt
tttatattca 6780 gtacctcagg cccgtatgat tatctgctga tggccccact
tagatgtact tagccacttc 6840 aaaatgggcc ctctccccaa atctaagnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6900 nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6960 nnnnnnnata
atatatagtc actttactcc taaatatata ttatatagca tatataatat 7020
gctatattat atatcatata taatatgcta tattatatat catatactat attatatatc
7080 atatataata gtatatgtat atttaggagg aaagcgattc tggaatagag
tgtagaattt 7140 gtggattatc agcctgagaa gggacaaagg gcattagggc
atcatttaca cattatgagg 7200 gtgttagaac agaatatggt tatcatggat
tttcagatcc actaatgttt actttccatt 7260 taaggcacat caaatcaaga
gatagtcagt acacataaaa gaggagattg actttatgta 7320 tttatcaaat
atttcacaaa tataaaatat tgagcatatc atgttttatt tatttattta 7380
tttatttatt tatttattta tttattggtg acagagtctc cctctgttgc ccaggctgaa
7440 gtacagtgac atgattgtat aatagctcac tgcaacttca aaatcctgga
tttcaggtga 7500 tcctcctgcc tcagccttct gagtagctgg gactacaggc
ttattagcta gtagtagcct 7560 ggctaatttg taaatttttg tagagacaga
gttttgcttt gttgtcaagg ctggtcttga 7620 actcagcttc tggaaatcct
tgtaccttag cctcccaaag tgctggaatt acaggcatga 7680 gccacagttc
ctggcctgtt accaagtatt ttttaatgtt tactagtttg atgggtaaaa 7740
atgatatatt attgttttaa ttagcatatt gtactcagaa tttagtctga agatcttttc
7800 atatatttat tagctgtgag accttggcta tttcagcaag tattttttga
gtaatttctc 7860 tttagcagta tgctggagat tgattaggga taaggaagaa
gtgtaaggcc tgattcatgc 7920 ctctcaggaa taatctacct ggggagatat
gttatatgta ctacagcaaa ataacatttc 7980 aaggcagctt ttacgtaatt
gcagctttag gggagtagtg gagagtttta aggggtaaca 8040 gggaggaatg
atagaatcag ttttgcacat gttaagattg agttcttgac tacattgcat 8100
tgaagatagg tcctttgaaa ggtttactac taaaagcatc agcaatagcc tacttctcat
8160 ttctagcata gagttacata aggatcattg ttaccaacaa acttactgat
tatattatat 8220 atattaccct tgagttaaaa aaagtctgaa atattttaga
gatatcaaca gaactggctt 8280 cctggccaga ggttgggtct agaaggagaa
atttgaaagt agtatcatgg aagccactag 8340 aaaagccagg agatgggatc
agttactgac agatttagag aaagaagagc tggaagccaa 8400 gggagtctaa
tgatgcccag tgagggcaaa ggcagtagga ctctttggag attatccaat 8460
agtgttttct actttactct agttttcatt gataagggtc ttgagagttc caaataaatt
8520 gggagccgac gattgtgcgt gtgtgtttgg aatccttggc aggaatcatt
gcagaagaga 8580 tgccattggg gctcagtttt ctactttgct ttttgtgggg
gagcaggtgg atctttctgg 8640 caagagtgcc tcagtggcta ctggtcttac
tatgtctgaa cttattcctc ctgtatactc 8700 caggtgccca gggtgttgcc
ttcactctgt tcctagcagg tagcaccctg ttgttgcttc 8760 ctgtgggagt
gagggcttag gcaggggtgt ctgctcaggt gcactagcca agcttctgtt 8820
agttgcttgt gggccttttt ctggcctttc tgcttttgtg ccggagttcc tgttcacact
8880 ctttgggatg gtgcccttga aggcccttga gcctgctctg ggatgctatt
tcccttttta 8940 gcccatctcc agctgttttc tactttatgg ggattcttca
cagcttctgg ccgcctgtta 9000 tttttttagc atggctgtgt aatcactggc
tatttaaaaa aatatgattt atattatttc 9060 tagggtttgg tgagaaaaaa
cggggaagga ggcactgtac tctttactca attggctgtc 9120 tcgatttttt
ttgttaacat tctgttcagt gtctctcctg atatgcttgt aggctttatt 9180
catactgttt tagaaagatt tcatagtgtt cttggactga gcagttattt tgatttatta
9240 attttatttt tgatacaaag tcttgctctg ttgcacagtg cagtggtgta
gacgtggctc 9300 actgcagcgt cgaactcctg ggctcaagcg atccttctga
gtagctggga ccacaggctt 9360 gtgccaccac gcccagctag tttttaaatt
ttttgtatag atggggtctt gcccaggctg 9420 gcctcgtact cctgggctca
agcaatcctc ctgctctgtc tcccaaagtg ctgggattac 9480 aggtgtacag
gtgtttgatt taagacttaa ttttgtggtc tatcctagcc tctttgaaaa 9540
taaagtttat ttcctataaa ccaatagaaa acagtcatag gatatgagca ggtaatggtc
9600 ttattcacgg caagagagat gcaaaataaa attgtattga aaaactgctt
tttaaaaaaa 9660 atctaagttg gcaaggatca gaaagtttga ttaaacaatg
gtggctgtgg agtagagaaa 9720 taggcgttgc tggtgagaat ccaagttggt
acaacctctg tagaaggcag ccaggcagta 9780 tctatcaaaa ttacagatgc
atataccctt tgacccagca attctatttc tctggattta 9840 tcatatctgt
ctactcatac atgtgtgaaa tattttatat gcttatgtaa gtgatagtat 9900
aagatataag taatgtatat atcttattgg agaatgacat ttatttttta ttacttggag
9960 aatgatttgt aatagcaaaa gatgtagact acctaaagtc catcaatatg
gtatttgaga 10020 aattataaaa tggaatgtta cacaattgta aaaaggaatg
aagtgcttca tatatggata 10080 tataatgact tcctatatat tgatgagtgg
gaatagcaga gtagagagga atatgtcata 10140 tgctatggtt tgtttaaaaa
ggggttgaac atatgtttgt atatacacag aatgtctgtg 10200 gaatgatgcc
caagaaactg tgaatgtttt ctctgagttg agaaggtggt tagaagatgg 10260
gatgggaagg agattttcac tgtctatcct ttgaagcttt tgtattttgt accatgaata
10320 ttactgatac aaaaagaaca taaaataaac agaaacatct gacaaatttt
gttagtagac 10380 tctttgatag tattgtttct cgttgttgct tcacctggtg
ggaggaggag gttgattcca 10440 aaatcaaatt ttgttctttt gaaaattcag
cattcatgta cttaaactcc tagagtaaaa 10500 ttgcttgctt ttaagttacc
acacaaaaaa agtaagatac tggtctattt aactgagaac 10560 aaattgttat
gattttcatt tcttttgatc tggtgtcatt tttttcctgt taattttaat 10620
gaagcacaga gaaggaaaat tgagtacatg gtagagccag gaggacccat atttaaattg
10680 ctgtcagcaa accaacactc tttgaactaa cccactttca tccatacagt
tagaggtact 10740 tattcagtac actaatatta gacctacaat cctaactgct
aattagcatg agtcccctga 10800 taaatagcac actgtaaaca agtagtcaag
gtctttttta ctcgtttgtt taaacatatg 10860 gtttattgag gcatattcag
ggtcacaggg attattggac aaataaaaat aatttgaaag 10920 ctttggctaa
aaaggaacta gcaatatcct taaggaggtg gtggaagaca aaatctgttg 10980
tatactcctc agagttaatg aaattaatgc agaatcccag aggacccaag aacattactt
11040 attttgcttt tattgaaaaa gttcaatttt gaataaaatc tgaaagaaat
aatttattgg 11100 gtagctggga gaggtggctc atacctctaa ttccagtgct
ttgggaagcc taggcaagag 11160 ggtctcttga ggccaggaga ttgagattag
cctcagcaac atagcaagac gcccatctct 11220 ataaaaaatt taaaaaagtt
agcagggtgt gatggcatgt atctgtaatc ccacctactc 11280 agaaggctaa
ggcggaagga ttgcttgaat tcaggagttt gaagctacag tgaattatgt 11340
tcatgccact gcactctagt gtgggtgaca gagtgagacc ctatctctaa aataagtaaa
11400 taaatttatt ttggaaaact agtctaagtg aaagaacatt ctgtaatagg
acaccgagta 11460 actagaatat gagatcctaa tatctcatca tgtttaatat
ggacgatgaa gtaacaatat 11520 gtaaaaacaa tcctagtggt tgtgaaagaa
agtacctatt agtctgattt gttggcacct 11580 ctctgggaca tgtagattct
tttttgtttg tttgtttttg ttttttttga gatggagtgt 11640 tgttcttgtt
gcccaggctg gagtgcaatg cacgatctcn nnnnnnnnnn nnnnnnnnnn 11700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
11760 nnnnnnnnnn nnnnnnnnnt ggattccaca tgtttaggtg tgtccttcaa
ccccatcacc 11820 ttttcaccac tgcctgggct tgatgtgttc tctgtagaag
attttttaaa atacagatag 11880 tataaaaatc cttcctgacc cctcatttgg
atatttttta atggtgcctt ttttttaatt 11940 gttgacgttc aagatagact
ttaaacaatc tgaaggaaaa taaatcaata tcaatgacag 12000 tcatgcacac
tcaagcaatc tgtttcaaag cctaatcatt tgtcatctat tctcagtgtt 12060
tctattataa tttttattat aataatagta caggctgaat ccccagcacc tatagcagtg
12120 cctggttcag agtcgatact taaatattta tggaatgaac actaaatgtt
ctctcaaaaa 12180 atgataattc agaaatatct gtatattgca aaaagtaaaa
ggtcttcctt accctcccct 12240 gctccattct gatgattatg tgaaaggaaa
agcctctatc cttggtgaat ctctcattta 12300 gcttttcttt tttaagaagt
tgtgtattct ggtggtcttt aacagaagag ggctatgtgt 12360 tattgggggt
tcattgccac ctgtaggagg caaaataacc tgtgatgagt tggccccatt 12420
gaagtaccac acctctagga agccttccct tcctcccctt ctcttgccct tgtttctgca
12480 agctctgtac aacacttctt atccgggtga ccttgcccta caggtagctg
gctacctgct 12540 gtgtctttca caggatggtg agctccttgt agacagtgct
gtctttatct tgccacctcc 12600 cacagtgcct tggagggtac agttgctaaa
cgttttggaa ctaaacagaa aaaaacacag 12660 tacaataaga aattaccata
atgctaaatc aacaaattac tcgaatctct tcccctgaca 12720 ctttagtagc
tcttgaaagg gcaatttcag tgatcttgtc aaacagctaa gtcacatggt 12780
gacctagaag agggcttgga agtttgagtc attgccgttc aatactcttt cctctagaca
12840 tcctgacccc catcctctgc aaaaccatgg gcagtgcaga gtaggtcaca
agtattgtgt 12900 ttttatttgt ttgtttgttt ttagagacgg gatcttgctg
tgttgcccag gctggtcttg 12960 aactcctggg ctcaagtgat ccccccaccc
tggcctccca aagtcctggg attataggtg 13020 tgagccaaca tgcctggcct
gagttgtaaa tcttccaggc tcgtgccact ggcttctggg 13080 agactataag
atatgaccta gtgtaaatgg aaataatttt tacctatttg ggttcaaaga 13140
caccaataaa tctgttcttg gccaccgagg tcagttctat ttcttcaaat cttgcctaga
13200 gtagtgtttg cacctcatgt tatgggttga attgtgtccc tccaaaattc
atttgttcaa 13260 gtcctaaccc ccagtacctc agaatttgat ctttcaaaag
acaaaattag gattgggtgt 13320 ggtagctcat gcctgtaatc ccagctactc
aggaggctga ggcatgagaa ctgattgaac 13380 ctgggaggtg gaggttgcag
taagcccaga tcgcaccact gcactccagc ttgggcaaca 13440 gagcgagaaa
aaaaaaacaa aacaaaatta caacaaattt aaatatctta actgctttta 13500
tttacaattc tagaatcaag caacacctca tcctataaaa taaaacgggt gttcccaaga
13560 gctgagcaga ggagtttggt ccaatggaga gaaaaaggct aaggaaagcg
gaaacagaaa 13620 acaaaaagtg gattggttgt ttcagagtta ctttcttgtt
aaggctgaag cagaggggat 13680 ttccttatca tgccggctaa aactggcttc
tttggggatt tggctattat ccctcactct 13740 cttcatttct cagatggtca
gataaacaaa ttagtttcaa tttggtgaca tggaacctta 13800 gcatgaatga
ctccattttg gttgggccta gtgcaggagc tcagtccaag ccaatggccg 13860
cctataaatt ttatttaaca ggctttattt ggaaataggt acattgtaga tagaattagg
13920 ttataatgaa gtcaccaggg tgggccctaa cccaatatga ctggcgtcct
tatataaaga 13980 ggaaatttct atgtaaacac acacacagag gaacatgtga
agatgaaggt ggatataagg 14040 gtgttccttc tacaagccaa ggaatgccaa
gaattgtcag tagaccagca gaaagtaggg 14100 gagagcatga aacagtttct
tcctcgcagc cctcagaagg aaccaactct gacaatgcct 14160 tgattttgga
cttttggcct ccaggcctat gagacaataa atgtccactg tttgtggtac 14220
tttggtatgg caccctagta aaccaatata cccaggtatt acagtcagat attacagtcc
14280 atgttagctg gaaacacaag ctaactctga ggaagccaag tgtgagtctt
ccaacactgg 14340 cagtgttggc aaaaggagct ctgggacagc cttttccagt
gagtgacagt gtgggctgtg 14400 cagctagact gctggtgtgt gagcctccac
tggctagctt tgcaatgttg ggaattgtat 14460 ttaacttgtt gcggctgtac
aatgggggac aataaataag taccttgtct tagtcctttt 14520 gagctgctat
aacaaaatac cacagactgg gtaatttaca aagagcaaaa attggacagg 14580
cacagtggct catgcctgta atcccagcat tttggggtgc cgaggcaggc ggttcacgag
14640 gacaggagtt ccagaccagc ctggccaaaa aactccgcct taaaaaaaaa
aaaaaaaaaa 14700 aagcaaaatt tttttcccnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn 14760 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnga 14820 attgtttata tgaatcattg
attatgaaat agtaaagctc attctctctt atttattttg 14880 atattttttc
tacttaaagt aatacttgta tattgttaga aaaggtaaat aataataaag 14940
gcaggttata aaaaatcagc agtatcctta cccatcccca ctttttaatc tcattttcag
15000 aggcagttac ttttaagaac tctgtctctc tctctctctt tttcttttgg
tagagatggg 15060 gtctcactgt gttgcccagg ccgttcttga actcctagcc
tcaaatggtc ctcctgcctg 15120 ggcctcccaa agtgctggga ttacaggcct
gagccactgc acctggccct aaaaattctt 15180 ttaagctttt tcttttgatt
cttacctctg cgtttataaa tctgcctaaa ttgctatttc 15240 gtgatttatc
aattttagat aatacatatt aacttcttgt tatggtaggt ggggtattct 15300
tccctttcct tcccctattt ctaaaagcac ttccagtata ggtatataag aattcttggt
15360 taatatagtg tttagctttt atattattat gactacataa atattgttca
ctgctggtga 15420 gtacttcacc atgtttcccc ttccctcccc ctagtttgct
tagttttcca tggatatatt 15480 attaattttt accaaatact ttgaacggcc
tgtgggattt agtgcctaag aaattgatgc 15540 aaggtgttac tctggctact
gctattgcag ttgttttgtg tccctgttcc agaggtttca 15600 tgcctttttc
agctttgtca gtaaagtaaa atctcagatc cccaccatgc ctgacttgac 15660
agtgtaacat cccccatttt gtttgtgctt tctttttgga actgttacta ttaatatatt
15720 aaaatcttct aaattgttct ttaaattttc tattttttct cctcctgttt
ttcacttatt 15780 tgtcctcttg ttctttatta tgggagttcc cttaactttt
atcttttctc cgttcttttg 15840 ttttaaattt caggtgtcct ttcttgttct
ttatttcctt ttttatgaca tcctactctt 15900 gcttcatgaa gcaatatgaa
acggttaaaa gagaatggtt tctgtaccta tcctacctgg 15960 gtttaaaacc
tgatgtgcca ctttctagct ctataatctt gggcaagtta cttaaccttt 16020
ctttgcttta gtttattcat gtaggttagg agttggtaga catttcatct aaaggaccaa
16080 atcataaata tttcaggctt tatcagccaa gaggcaaaat gaaggatatt
ttaaattatt 16140 taattatttc attatgtaag tacttacata acaagagaga
aaacatttct acaagttttt 16200 tattaataaa gctcaaaatg cgatactaat
aatgattgag aacaattttt gcaataaagg 16260 tttgctaatg agaagaatga
atgttttttt ggaggagagg ggataacatt tggcttaatt 16320 ggagtttaaa
gttagtgttc tctatcatca aaattgatta tagatgcagc attaaccacc 16380
tattaatgct gatttgtaat gagatttcat gtatttcatc tttgaaaatg tcttcttaga
16440 tactgccaaa tactgctaat agtctgtgaa catatggttt taatagagca
tattcattgc 16500 ttggacgaca tttacagaat tcttttagac tcttttcttg
atacttaacg tttagcaaat 16560 cattacactg cagactaatc acttccaatt
gaggattagg tagaagctcc tcattgcaca 16620 gttaaatgat ttttgaaatg
tggaatgttc gtttctactt gcattgaggt atgaaaaaat 16680 actgctggaa
atatttgatt ttggaaaata tgtctgctgc atatttgtgt ggcagtagag 16740
atcttcttat tttaattttt gacagcatag gaagtacatg aagcatcttg acatgacttg
16800 tgacttaggc aatgttagtt gtccttgaaa tgactgtctc aatataggtt
ttgcacgtag 16860 accctgttgt ccttctaact ttaggctgaa ttcattaaca
gatatatcaa gtctgcagca 16920 acaatagtag ttgagggtca ttcttttcat
tcagaaaaat ttgtctcagc ctggagcttg 16980 aaacatttca gtaaaactct
gccattgtta agccattgta ttgtttcgtg gcaggacgcg 17040 tcaggatatt
tagcttctat ttctgacaaa aatgtcatga gaacaaatga aatttacctg 17100
tgacattacg gttcaataac acatgataga ttcagatgtt ttctgcagag tacctgctga
17160 ttgagaatat gattaatagc cataagcttt aaacacctta catttcacaa
ggcttgtaaa 17220 ttttgtccag ctaagccttt ttctgcttca tacatatttt
taccaccatc agttgttaca 17280 catcttagca gattctactt cagattgtgc
tgaattagta tttccttgat tttttggaaa 17340 atattcatag ctgtaattgt
ttcatacata ctgtacttcg agccactgtt ttcatggaaa 17400 gagtaggatg
ttaaagatat ttattttctc tggacacaat tctttggctg ctgtaatcaa 17460
acacaattta attaactcac cattggcaaa tactttcctt gcttgcttaa caaatgagcc
17520 atttggaaat ttacttcggt tgcagcccta tttccatttt taatttttgg
caagacattc 17580 tgctctgagg aggtatatct tgttttacat ttgcccattt
tcctgctcat tgctctcatg 17640 agttgggagt gaatgctgtg tggcagggca
tatcgggata ttgtgatgag tgcttagtct 17700 agtaatactt cctatattgt
attttgctgg cacagcttcg tgatgctttt acataataaa 17760 gtactttgac
atctaactag atttaaacaa tctacagtcc actgtgactt acaagtgtga 17820
catcagagta cttctgtttt tttgacgtga tagtcactgg taaaatagtt atagtatggc
17880 aatactcatg acacttgaaa tgctgttgag taaaccgtgt cattgagatt
tgtggtgcac 17940 tgagagtata aagggatgag ggcaccaaat atgatctctg
tagcaactac ccaagtctgc 18000 tgttgtatca ggaaaacagc tatagaccat
gtgtaaacaa atgagcatgg ctgtattcta 18060 ataagacttt attgacactg
aaattttctt ttcatataat ttacacatgt cacaaaatat 18120 tcttttgatt
tttttcaacg atttaaannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
18240 nnnnnnntga gcttgaagac ccctgagccc agatgagaac cgcggacctg
cctgcatcct 18300 gattttagcc atggtgaaac cctgagcaga gaatccaact
agaccatacc aggacatctg 18360 accccttaaa ctgggaggta atagatttgg
gttgctttaa gcccctacat ttgtggcaat 18420 ttgttatgca tggagaacct
ttatgtctag ctaagggatt gcagatacac caatcagcac 18480 tctgtgtcta
gctcaaggtt tgtgaacaga ccaatcagca ccctgtgtct aggctcaggg 18540
tttgaggatg caccaatcgg cactctgtat ctagctaatc tggtggggac ttggagaatc
18600 tttatgtcta gctaagggat tgtaaataca ccaatcagca ctctgtgtct
agctcaaggt 18660 ttgtaaatgt accaatccac accctgtgtc tagctcaagg
tttgtaaatg caccaatcag 18720 cactctgtat ctagctcagg gtttgtaaat
ataccaatca gtactctgta tctagctaat 18780 ctagggggga cttggagaac
ttttgtgtcg agctcaggga ttgtacacgc accaatcagc 18840
accctgtaaa atggaccaat cagcaggatg tgggtggggc cagataaggg aataaaagca
18900 ggctgcccca accagcagtg gcaaccggct caggtcccct tccacactgc
gggagctttg 18960 ttctttcgct ctttgcaata aatcttgttg ctgctcactc
tttgggtcca cactgccttt 19020 atgagctgta acactcactg cgaaggtctg
cagcttcact cctgaagcca gcgagagcac 19080 gaacccacca gaaggaagaa
actccgaaca catccgaaat cagaaggaca aactccacac 19140 acgccgcctt
taagaactgt aacactcacc gtgagggtcc gtggcttcat tcttgaagtc 19200
aatgagacca agaacccacc aattctggac acaatagcac cttctaactg aaatactgga
19260 aagagagttt tcattgttgt agaatttgct taattattat cctgatagca
gggataatta 19320 ccaacaaaaa ggaagcacga aagttttact aacaccgagt
ttgctagaac ttcttattgg 19380 gtttggtaat atgtcacacc ctggctatgc
aaagaaggtt ataaaggaaa gagattttct 19440 gtggaagtca tgaagggatt
gataactgca ggaaagatct agccaaggtt aacactaaag 19500 ttactccagc
cacccaaatc caatgccact tatcctaaaa ggaatgttac ttttatatta 19560
acatttcaac aacatctggt ggaggcaaac cagtgttaca acccatcaga atagcaacag
19620 aatcaaactc caaatgatgc tgcagacaga accacacacg gacatgcctt
tcttccaagg 19680 acccttagat tgaccccagg aggagcccta gctgctgatc
cccacatgat gccccttttc 19740 agcaggaagt agccagaaag agtcatcacc
caacaccccc taacagcagt tagggttgcc 19800 actccagagc agggaatgat
gatataggag ttaacaagga attacttagg cagatagcaa 19860 gggcatggga
gtcctcagta aggctgttct ttttaatgaa aagcagcccc aaatcatttt 19920
ctaacaaaga gcagcctgca agctgggagc ttgcacacga taatgcctgc agaaactaag
19980 gactagacat tttcaaaatg gcggctccat cttcccttct ctgccagcca
catgtactgt 20040 aaaggagcag acaggatggt gccaatcaac tggaaagccc
atttgcataa gattaggttg 20100 aggcaaccag ccttccccac acactctgta
gacgtcatgc atgatcgaac caatctgtga 20160 gccctatgta aatcagacac
tgccttctcc atataaaaat ctgctgcagg ccgggtgcag 20220 tggctctcgc
ctgtaatctc agcactttgg gaggccgagg cgggcagatc acgaggtcag 20280
gagatcaaga ccatcctggc caacatggtg aaaccccgtc tctactaaaa tacaaaaaaa
20340 aattagccag gtgtggtggc acacgcctgt agtcccagct actagggaga
ctgaggcagg 20400 gggatcacct gaacctggga ggtggaggtt gtcagtgagc
tgagattttg ccactacaat 20460 ccaacctggg caacagggcc agactccatt
tctaaaaaaa aaaaaaatac aaaaattagc 20520 tgggcatggt ggcaggtacc
tgtaatccca gctacttggg aggctgagac aggagaatca 20580 cttgaacctg
ggaggcggag gttgcagtga gccaagactg caccattgca ttccagcctg 20640
ggcaataaga gctaaactcc atctcaaaaa aacaaaacaa aaaagaaaaa gaaagtggcc
20700 acccctgtgg aaaaggactc tggagtgggg agggtggtag agcagttttt
tatattaagt 20760 ttgtcatatt agttgacttt tcaaaatcac atccatatac
tactttgatt aaaaataaaa 20820 tattttctgg ccaggcacag tggatcacgc
ctgtaatcac agcaactcgg gaggctgagg 20880 caggaggatc acttgaggac
aggggttaga taccagcctg ggcaatatag caataccctg 20940 tctctaaaaa
aaatttttta attagccagg tgtggtggtg catggagatt tcaacaacaa 21000
caacaaaaaa agcacaaccc ataaaagaaa aaaatttata aactgagctt catcaaatta
21060 aaaacttttg ggccaggtgt ggtagctcat gcctataatc ccagcacttt
aggaagccaa 21120 ggcaggcgga tcacttgagg tcaggagttc aagaccaggc
tggccaacgt ggtaaaacct 21180 catctctact aaaaatacaa aaattagcac
agcatggtgg tgtgcgccta taatcccagc 21240 ttctagggag actaaggcac
gagaatcact tgaacccagg aggcagaggt ttcagtgagc 21300 caagatcatg
ccactgcact tcagtctggg gaacagacca tgactccatc tcaaaaaaaa 21360
aaaaaaaaaa aagaagtgaa atgaaggaca gcaatgtata tgtgaactga aaatgcaaca
21420 gacaggcaga aagaattagg aatgcttgtt attataaggt attgtgcaaa
ctgtgaagtg 21480 gtgatgtnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn 21540 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnntgt gtgtgtgtgg 21600 gtattttttt ttttttttct
ttttttgaga caaagtgtct ctgtgtcatc caggctggag 21660 agcagtggca
tgaacacggc tcactgcagc ctcaacctcc tgggctctag tgatcctctt 21720
gtcccagcca cttatgtagc tgggaccaca ggagtatgcc accatgccca gctaattttt
21780 tgatcttgta gagacaaggt ctcactttgt tgtgcaagtt ggtttcaaac
tcctgggctc 21840 aagctatcct cttgcctccc aaagtgctgg gattacaggc
gtgagccacc acatctatcc 21900 cctttcagat atcttaatct tggtaaattc
tttcagttac taatctgtga tgaactaatt 21960 tttttcttca catatatcaa
cagttgagga gctcaagctt gggaaaatgg tgtgcattcc 22020 ttgtatcgtc
attccagttc tgctctggat ctacaaaaaa ttcctggagc catatatata 22080
ccctctggtt tcccccttcg ttagtcgtat atggcctaag aaagcaatac aagaatccaa
22140 tgatacaaac aaaggcaaag taaactttaa ggtaagaaca ttcacatgcc
ttgaataaga 22200 gcagtgaaag ggggtggtac ttgggtgaaa cactagattt
tggaaggaca agttttagaa 22260 ccagaagctt caatagtttg tgtaacattt
ggcttaaatt aaagttttaa agtaggcctc 22320 tgattaatgc atttgtcctt
tggccaaaat gataaccata ttttctgact ggtaagtgca 22380 atggtaaata
gctaatggat gaggagagat tatgctgata caaaccagtt tcactgattg 22440
atgactttga taagagattt aattagaagg atcatagaga tttaaaaaaa aaacaatttt
22500 tttaaaaatg agtggacaac tctgttgtct ttagaattgg tgctttttta
gattcagctt 22560 tgtactcagc tgcactaatt tagccatccg gcccgtttct
ggaagcaaaa tgttttcact 22620 ctggagcttg tctgttttta aagagaatgt
ttcttgagct gggcgcggta gctcacgcct 22680 gtaatcccag cacttgggga
ggtcaagatg ggttgatcac ctgaggtcag gagtttgaga 22740 ccagcctgac
caacatggtg aaacctggta attcccatat tagcccggca ctggtggggc 22800
aagcccgtag tccccactac taggggagct gagatgagag gattgcttga acccgggggg
22860 caaaaggttg cagtgagctg aggagaaact tccctgcaat cccccctggg
ggacacgagc 22920 cagaccccgt ttggaaaaaa aaaaaaaagt aggaatcatt
cttcaggcag cacatagggt 22980 ttagcccttg ggctgtaatt tgccaattta
tgatttaggc aatgagaaaa aaaagtacca 23040 cgccatagtt tgtggtgagt
gtaaaatcag ttagtatatg tgaaacagtt aagatggtga 23100 ctggggacat
agtaggtgct aaatacatgt ttggtattat tgttactgtt ttcattatta 23160
tctatctaaa gatattttag tttttaattt tttcttagaa tcatctgttt tctatgattc
23220 ctttctttag tttgtttcag tttctttttt ttatttttga gacaggatct
ccctctgttg 23280 cccaggctgg agtgtggtgg cacgatcaca gctcattgca
gccttgacct ctcaggctca 23340 ggcaatcctc tcacctcagc ctcccaagta
gcaggaacta taggcgtgca ccaccatgtc 23400 tggctaattt gtttattttt
ttgtagaggc attaaaaatg tctctgtgtt gcccaggttg 23460 atctccaagt
cctgggctca agtgattctt ttgtcttggc ttcccaaagc gctgggattc 23520
taggagtcag tcaccatgcc cgggctgctt tggtttctat atttcatgct ggagacttta
23580 ctcacaagtc taatcatttt tgactgtcca ttcttattta aagttgagac
tacccaaaaa 23640 ctgattggaa gctctttgtg taagtagatt ttgttgagtg
gtgggcattg ctgtgaggtg 23700 acgatctatt ttttaaattg gcctggcagt
tcctaaattt ctgtatcttt tccctaggtt 23760 cctattcagt ttctcttgag
aggaatcctt cagtctcctg ccttggaggc agggaaactc 23820 actgtggagc
tgtagcaagt tgactttatc ttcattctct tgttttcttc attttccacc 23880
ttattaccct ccccaacctt ggcattggtc tctctagttg tatttctctg ggaagcacgc
23940 ataatagtct cttcctgggg agagagaccc ccaggcttta gtcctgcacc
ttgccccgtc 24000 ttccccagtg ccctgtctct cgctctttag ccttcccacg
gctccatggg gtgaattgcc 24060 ttccttcttg ttggtgtccc ccttggcagg
aactcctttt ggggcttcct caggtcggct 24120 ggttcaggta cactcctctg
tcaccttccc atcttccaca cttcccttga tctgatcttt 24180 gtgggtttat
atctttcttt ccattgcttt cgtttcattg ggcggggaat acccaactgt 24240
acttaatata gcacttggag cctagttgcc tttcagagaa tgttctatta cttgtggact
24300 catggcacct gtggcattta ctctgtcctt tggctggtga ttattgccca
ttatttctct 24360 gatctcctgt ttcagctttc tccttaaagt ctctgaggta
caagtggggc aatatgtgtg 24420 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 24480 nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn ggcatcccgg caagtcatgc 24540 aaaaggcaaa
ggctggcagg ttgcgctggc tcttgccagc cctcccaccc ccacctcctt 24600
cccttatacg gctccctaag ccagtgctgg tgctgtccag ccagccgagc ggcctggcag
24660 cagctctgaa accttgtcct catgcctgaa cctggaggtt tgagaggcaa
gaaggctgtc 24720 agagctgtgt ctcctggagc tgccttttaa tcttggtgta
ggtgtcttga aagttcaggt 24780 ggcagggtag ctggctttgg tttgattcgt
gcttgcaggg agcgtctggt gggtcgcttg 24840 tgcttagaag ctgccgggcc
tattccccca ggttgccagc cttttcctct tcaacactct 24900 tgtgctcccc
cgactcttcc tcttcccact cctcctccct ttcctcctcc tggcttttag 24960
cttctcttcc tcttgggttc tgtatggcag cctttgccag tggaggcagc ttgccctggg
25020 ggagccagag tcagtcagct ctgggggagt cagaatcaga gtgagaacta
agtcagctga 25080 taagcagtgg agggctgggg agcctctaaa ctgaacccca
tcatctcatc ttctagtctg 25140 ctgaggttgt gccaaatggt ctgtgtgggc
ttgtgtatgt gtgggagggt tactgtgaat 25200 gaatggaaag ccttgcttta
ctcaacatgt ttccaactct ggtgctaact agaagcattg 25260 cctagggcag
gtctcatctc tggctcctca cctgtaaaat gctaaagttc cttctaactt 25320
ctgtgttctg ggcctctgag tatgtgtgag tcatttcctt cattgcaaaa agtatttact
25380 gcatacctac ttagtgtcag acactattct gggagcaggg gagagagcag
tggacaaaat 25440 agatggcaat ctgtgccctt gtgacactta catttcagtg
gtgggaagac agacagtgca 25500 ctgattaaag tatcagtggt gctcagtatt
atggagaaaa atcaagcaga ggaggaaggt 25560 ggggcatgtt ggtgggggaa
ggtggtgcga ttttatgatg tggtcaggga aggcctttct 25620 ggagaagttg
accattgagc aaagagctga agggggtgag agaaggagcc atgaggacat 25680
ctgggtgagg aacaatcaga aagtcccaga ggctgaagtg acccaggcca aaagtagtag
25740 gaatgtacct agagaacttt ggggtcagag caggtcagac tctaagagga
agagtctttg 25800 tccatatgtg ggtttatccg cagatctgtc tcaggaatcc
aggagacttc ttttctccta 25860 ggtttcccca tctggcctct gcatgagtgg
ctatctgggt agaaggtggg gagttgtcga 25920 actcattatg tccgtggttc
aaatttctgc tggttggggc ttttgttcat tactttcatg 25980 acggttaacc
tgacttccgc tcatgtgcat tcagcagcat tttctggaac cttatccctc 26040
ttacatctgc tgcattcttc cccctctctc cctcctttcc cctccgccct ctccaccact
26100 atatctcttt ccttttggta tcttcttcct tttgcttctt aactctgaga
taaattaact 26160 ccaagatggt catttggcat ctttccctgc tgggtgatag
gagagtttga tactctcact 26220 ttctagccag ttatccagtg atgcatccca
ggatggctga aagagtgctg ggtggggtcc 26280 atttatgact ttctgaaacg
gtgtcatgat gacagcacct acttagtgtt aagccacagt 26340 ggccatcagt
gacatgagct gcactttggg agcagggccg tctcctaggt ggcactgtgc 26400
atgagcagtg aagctggaag gggggatttt tgttgctttt aggagtttct ccatggcttt
26460 agtcatttac ttaacaaacc agatgaatgc ctggcacatg ccatcactag
aaagggcact 26520 gaggatgcct gagtttccct agatgggaac actaggggaa
gcctattttc cagcaggtca 26580 acagcctctt gcctccaatt ccaaaatcca
caaactctca aaattggaaa atgtgtttgg 26640 taacttgttt ggcagcaaga
cctggcctta cctgatctga acttatttgg cagcaaaaac 26700 ctggcctgag
ataacaggag gctattggtt atctttatat ttgccctcaa atgtgagtgg 26760
ttatgtattc tctgcagaaa tattaggatg tttgatccag ggggaatagc ccaggcccca
26820 ctggcagcat tatataatat atggtgtatg ctccatgatg cctttctaaa
atctgaaaac 26880 ttctaaattc tgaaactcac ctggtcccaa gcatttcaga
aaaagaactg agaacctgta 26940 ctctaaaagt aggaaggaag tagaactcct
tttgatagga aagaagaggg aaatgcaaga 27000 gagagatcta tttatttcag
agtgacagta attaatacta gtgactaatt aatactcttt 27060 aagtataaat
gagatgtcct tttttataaa atgttcacag tttttctggg aggtgaaaag 27120
ggaacattca gcagatgtaa aaaccgaaac ccagatggct taagcaaatt gctcacgatt
27180 gaactagaat cagaccccag gtctctcact ccgcaagtct gctagatgca
cccacgctct 27240 gttctgtctc cccagataag ctccacaaac ccaaagctac
acagactgag gtcaaaccat 27300 ctgtgaggtt taacctccgc acctccaagg
acccagagca tgaaggatgc tacctctccg 27360 tcggccacag ccagccctta
gaagactgca gtttcaacat gacagctaaa acctttttca 27420 tcattcacgg
atggacggtg agcccgggga gggagctctg cggctttata taagatttga 27480
ttccctttgt tttggtcaat tagaaagaat tctggtgttt ccagattcca aaccctcttc
27540 ccccctttcc ttgtgggctg cttgtatttc agacagctgt gaagaatgta
acgggcattc 27600 actaaggggc aatctggact ccagcagggt ggtattaatg
atggcataca acgggctttc 27660 agaaagtggc tctcctgagg gcagcagccc
agctccactg gctcttaagg acccctctaa 27720 ttacacttaa ttacgctggt
caaccactgc ctggaggggg ctgtcctgcc gtgagagctg 27780 agcttaacta
aagcaacttg actggctctg agaacctatg agtagccagc tggcctggat 27840
tgctgactgc ccttggcata gtgccctcct gtttgcatag agatagcccc gtttaaaggc
27900 actggggctc tttatgtgcc ctagctgagc aattcacatt gaaaagccca
tgacaaactt 27960 caacaaaaaa gggctttagt gctcagcttc agaagctttt
gaccagccag gaatttattc 28020 attcatataa tgacagtctg tagggaaatg
gcactattaa gtgagcagat ttctgcctgg 28080 gctaattgga aggggacagt
cctcctctta atgatgagaa attcatatct gttacatgct 28140 tttggggtct
ttaaatctgt catccatggt tgaggtcagg ggcaggagag ggtaggtgcc 28200
tgcctaccta gttgaatgaa gagatgatta agagcctgtc taaccctgct catcacacaa
28260 cctacaatca gaatcatatg tgtgaatctt tttaaggccc cctgtcaaaa
tgcaaataca 28320 agctgcctgc gacttacaag taggttgcat tccagaaagt
tcttttgtaa tctgtttgga 28380 acttggaaca gcagtttccc acagaagcaa
gattgtaaat ggtgtttggg ttcccaggct 28440 aggcacagaa aatctatcta
tttgataatg tgcttgtgga taggtttaca actggaccta 28500 gtcaccattt
ataactttgt ttctgtggaa aaatacattc tgagttgtaa tttgggattc 28560
cggggacaga ttttccctac tctggggtca agagggatgg cagagatggg ttgtgggaag
28620 gggtcatttg ttaactctgc attcacctag gagacagcat ctccctgcgt
ctctaagaga 28680 gaagcaattt tccagggcaa ccctccctag ctgcctttga
aggatggacc aggccacttg 28740 cctgcctgta acagggactc agaccagcct
catgccagta tcacccttaa cacgtatctc 28800 atagtggccc taacagacag
tggggcaaca gtataggaca ttagctagga aagttttgat 28860 gggaaatact
ggggatgtaa ggagcaatgg aagacaaata cctgcgtagt gattctgcct 28920
gtgctggtcc tgctcatgtg caaatgtttg gtccctgagc agccaatgtg cagattctaa
28980 aattgtctgg gggcactggg catggtggct cacgcctata atcccagcac
tctggaaggc 29040 ctaggtggga agatcgcttg agcccaggag ttcaagacca
gcctgggcaa catagtgaga 29100 ccctgttgct gcaaaaagtt taaaaattac
ccaggcatgg tggcatatgc ctgtaaccca 29160 gtcactctgg aggctgaggt
gggaggatca cctcagctca ggagttggag gctatcatga 29220 gctgagattg
ttgtcagtgc actccagcct gggcaacaga gtgagaacct gagtcaaaaa 29280
aaaaaaatta attgggaaga gggtcatata gaaaggaatt ccatattttt taggatttct
29340 gaaaccaaga ataaaaaaca acttccactt ttctctgcag atgagcggta
tctttgaaaa 29400 ctggctgcac aaactcgtgt cagccctgca cacaagagag
aaagacgcca atgtagttgt 29460 ggttgactgg ctccccctgg cccaccagct
ttacacggat gcggtcaata ataccagggt 29520 ggtgggacac agcattgcca
ggatgctcga ctggctgcag gtactggggg atgagaggga 29580 gtctcctgtc
accagcagga tctcaaaccc aatcttctta agaaatgcag gtcatgcatc 29640
tgttgccatg aacttctgga gtctgataaa aatctttgag attaaaagtt ttattgaatt
29700 aagtattgtt tggaatactt gaaagctggg actttttgag agccttttaa
ttattgatag 29760 atctctggat ttttcctgtt acttaatttg ctgaaaattg
gccttatggg ttgtttcttc 29820 ctgatcttag aaacagatgc ccttaggttg
gttggggatg gccaggaacc aggccaggct 29880 tgtgatctga aattcctaca
aagactgctc ttgtctctga agcatggctg tgctgagggt 29940 ggggaggggg
ttatttcaaa aatgcagcct aatatctctt ttctttgaga tggagtcttg 30000
ttttgttgcc caggctggag tacagtggtg tgatcttggt tcactgcaac ctccacctcc
30060 caggttcaag cgattctcct gcctcagcct cccgagtaac tgaaactaca
ggcctgtgtc 30120 accatgccca gctaattttt ttgtattttt agtagagatg
ggatttcgct gtgttagcca 30180 ggatggtctt gatctcctga cctcatgatc
tgcctgccta ggcctcccaa agtactggga 30240 ttacaggcat gagccaccgt
gcccagcctg cctgatacct cttttataat atgaagtgtg 30300 gaaaacagat
cttgaagtct tatatttact tttttttttg agacagagtc tcgctgtcac 30360
ccaggctgga gtgcagtgcc atgatcttgg ctcactgcaa cctctacctc ctgggttcaa
30420 gcaattctcc tgccttagac tcccaagtag ctggttttac aggtgtgagc
caccatgccc 30480 aattaatttt tgtattttta gtagagatgg ggtttcacca
tgttggccag actagtttct 30540 aactcctgac ctcaggtgat ctgcctgcct
cggcctccca aagtgctggg attagagacg 30600 tgagccaccg cacccagcct
atttactttt aataggttaa taatctgcct gagatcagtg 30660 gatttagctg
ggagaaggca gggcagggta cactgtcaaa gcggcaccat tatctgggca 30720
attccggcct ggccttcctt gttcccatgg aatgggatga attctggcag aattctggtc
30780 aggattctcg agcagtccct ctgtcctcta cctaagctct tctatagagt
ttggtttccg 30840 agccatgggg ttacctcctt accccccaga tgagtgctct
gacaggggac aatgcgtcaa 30900 gtctggggtc ccacatgggc ttgtgaggag
gaggttggca gctcctgggg ctgggtggag 30960 gtcaggcctt agagggcagg
cagagggcat tctgctgagg gctgtggttg gcactgcagt 31020 ctccagtgag
tacggcagct ttgacctcct caccatcacc ctcccctctc ttagatactg 31080
ccagaaagaa caggaaatgt gtagggaaca gccacatatg cagcctccag tcataccctc
31140 caccctgtcc ccacacttgg catttgcagt gccaccaagt ccttttggcc
tcccctaagc 31200 tggctgtgac ccacacatgt agcatcacca gcaaagccag
tggggccctg gggagtctct 31260 gtgcccacgg cccctgcatc tcctcctgct
ccgtgactga gttgttgaac tgctggtgat 31320 tctgggggct ctggaccctg
ctcttctgct cacatacttt ggtgactttc tataggagaa 31380 ggacgatttt
tctctcggga atgtccactt gatcggctac agcctcggag cgcacgtggc 31440
cgggtatgca ggcaacttcg tgaaaggaac ggtgggccga atcacaggtg agctccactt
31500 ccatcactaa agggctccct cagctgcgct aagccggaat gctccccaat
gaggcagcag 31560 agtgagtcat agaaagttag ctttggaagg aacctggaaa
gcatctaatt caaaacttcc 31620 caagcgtttt tagtcacaag gaactttttt
ttttttttcc aaattgaact cgcataggcc 31680 cgcagtatat gagacacaga
aaggggggtg ctgtgggtga agtggggtgg gtatatggcg 31740 gcttgtgtta
gccttgccag tgtgggcgtt ccccttccct ataggcatct cagagtctca 31800
gagcaccagg gaacacagtt tgaaaaccat aggcctggtc caataggtga ggaaacaaac
31860 acggagaggt gagacaactt gcccaggggc aaacagctaa taactcaaga
gcggaagctg 31920 gatagagccc tggccccaaa gcttttgggt gttcccttca
ggtctccacc caaggactca 31980 ggggaaaaga atgaatagta gattttagtt
tgaattctgc ctctgatttc tatcttgtct 32040 cccaatagcc tctttcccat
gttaaggtag catatttatg aatgagagct accaatttgg 32100 aaagggtggt
tcaactttgt aataaaagga acctttctga tattggtccc cagggggtca 32160
acagaaaatt gaattttcca tgttgaaaac tgcatcttag tgagctttta acatgagagt
32220 ttggattaaa tcatttaatg attgtgaaaa gtgtaaaagg ttttctttct
catttttggg 32280 cccctcaagt atatacacag agattcctct atgctacaat
taatggtaaa tttgttgccc 32340 tgaacttcta tccttcttcc agcattattt
tatttaaaat tacccctagc ttccccctta 32400 ctcccaagat tctaagggtg
atcacctaga aggatagatc tgaacaattc ctttccctgc 32460 agtgttttca
ttttaaaaca aaactcaggc tgggtgtggt ggctcacacc tataatccca 32520
gcactttggg aggccgaggt gggtggatca cgaggtcagg agttcaagac cagcctggcc
32580 aacatgatga aacactgtct ctactaaaaa tacaaaaatt agccagctgt
ggtggcgggt 32640 gcctgtaatc ccagctactt gggaggctga ggcaggagaa
tcgcttgaac caaggaggta 32700 gaggttgcag tgagccgaga ttgtgccact
gcactccagc ctgggtgaca gagcaagact 32760 ccgtctcaaa aaacaaaaca
aaactcaggt agaagagagt ccttagctaa ataacgattt 32820 ggtaaaggta
gaatttcaga tttcagtgac aagctgatat ggtagaattt taaaaagaat 32880
atttgtgaag ttttcctggc tctcctgaat cctgtccctg ggcttgagtc tagtatgtgc
32940 gtgcacacac atgagcatgc atgcacacac atgcctgttg atccaatgac
ttgattcatc 33000 ccagcttgag agctttattt ttgatttcca agactgtggg
gcttgagctg cccaaagcgg 33060 gctatgattg tgtggccacc catgactgct
cattaacccc ttgctggtgc aaagcagttt 33120 gactggaagc cactcgggtt
ccattgtctg agcgcctctt cctagcccct gaatgagagg 33180 tgtgatgttt
cagatccagg cacctgagtt caaattgtag cacacaccac agtccaggcc 33240
cagaatgtca gtaacgatga caaactgcac atcttgcctt tctctatttc taaatctgaa
33300 atgagatggg gctagggagg gaactttcca gttctttccc cctgcctgtt
tgagtggcat 33360 ctgctggggt gagggctttt ctcctgaggg tggcaggaga
gccaggcaga atgctaatta 33420 gtgctctggg atgtttgcat ggagcatgat
gcccacatgc cctgagcatg gtcccttccc 33480 tctggccttt ctctgtagag
aaggggcctg gcctctgtcc agttgccaag cagcacccct 33540 gacacacgct
gttgtgtatg tctgatgggg gaggctgcgt cctctccttt ccccttggta 33600
gacttctcat ggacctgtgg acaaggtgat cgcaactggt aagaggacag attgagactt
33660 gcatggggtc ctgcgtccag tgatgccact atgctaaggc caccaggcag
tccttagcct 33720 gggccttgca agggtatatc tgaaccccaa tcttgcttgg
accagagggt gtggatgggg 33780 gtttgctaga gttttacttt cttaggcttc
tgagagaagc ctgtgatact aggaaagagg 33840 tcatatattt atagttgaac
ctgtgccttg tttgctataa tcaggtaagc aagcagatga 33900
atttattcaa gaaatgtgtc catatgtgca ggctagatgc tagctaatgt caaatacctc
33960 atgtgtggcc gggcgtggcc gggcgcagtg gctcacgcct gtaaccccag
cactttggga 34020 ggccgaggtg ggtggatcac ctgaggtcag gagttcaaga
ccagcctggc caacatgatg 34080 aaaccccatg tctactaaaa gtacaaaaat
tagccgggca tggtggtggg tgcctgtaat 34140 cccagctact caggaggctg
aagcaggaga atctcttgaa cccaggatgc ggaggttgca 34200 gtgggctgag
attgcgccac tgcactccag gctgggtgac aagagtgaga ctctgtctca 34260
aaaataaaaa ataaaaaata aaaaacaaac aaacaaaaaa cacctcatat atgacagcta
34320 ctctatgcta tctctgaacc acatagcaac cctgaacatt ctacggaggg
ggaaactagg 34380 actcagtgat taagtaaagg gcccaatatc ctgggcccta
taagtagcag agctgggact 34440 caaacccatg ctgtcagatt ccagatccca
tgcacctcac tgctgtgcca tgctgcctct 34500 cttctgtgga cagagataaa
gtagccaggc atggtagtgc atgcctgtaa tcctagctac 34560 tcgggatgct
gaggtgggag aatcacctga gcccaggagg tggaggttgc agagagccga 34620
gactgggcca ctgcactcca gcctgggcaa cagagtgaga ccctgtctta aaaaaaaaaa
34680 aaaaaaaaaa agtagccgtt gaactacagc aggccctgcc ctgccgggcc
agaatgcaca 34740 gccctggaag ttttacatgt gtgcatgtgt gtgtgctcca
tttgctggac aaagcaactt 34800 tggaggagtc tatgactgaa tggaagaagc
ggcggaggtt ctctatctcc tctttattta 34860 aggaggcagt tctccctgtc
attcatccct agttaaaaaa gttaaatgtg ccactgtacc 34920 cctgaatctg
tgggccacag atatgtgtca gggacagtca gagcagggca ggcaggctct 34980
ggctgggtag gtgaaggccc agccttgcct gccagccagc ctgtgaaacc ccatcagctg
35040 cctgcattcc tccagcacag cctggtttcc atggcactga ccgtctggtg
gggacctttg 35100 ttcacaccaa gtaaagagcc tctctcttgt attgattgca
aagcagaatg ttgctctctt 35160 tctctttcct ccaggggaca tggtgagagg
cagggagagg ccgctgtgtc agtactgcgg 35220 tccttgcggc ctctgaaatg
ggttgtcgtg ggctgttctg ggagcacact gcttttgtgc 35280 catctttctt
ttgggtcctg ggctagggat aaactctcaa gcagcctggg ctccctttct 35340
gtcttggttg cacataaagt tatctaaatt tggctgggtg cagtggctta tgcctgtaat
35400 cccagctact caggaggctg aggcaggaga atcgcttgaa cccaggaggc
ggaggctgca 35460 gtgagccgag atcgtgccac tgcactccag cctgggtgac
agagcaagat tccaactcaa 35520 aaaaaaaaaa gaaaaaaaag ttatctaaat
ttttggaaac tatttagcgt ttcagcctct 35580 accagttctc atatgagtaa
tgagttctgc aagttgaccg tccactctag acggtagctc 35640 tgcctcttgt
ttatcctgaa actaccatct caagtctcct gataggctcc ctggttctaa 35700
tgtgctgtgg tctggtgaac acggtcgtta accatgtcct cctttcagga ctcttgttgg
35760 tcacatctcc tcccagcctt ggtgtttcga ggccaggttt tctcagccta
ggcaatattg 35820 acatttgggg ccaggtaagg ttttggtgtg gggtgtgtgt
gtgttgggat tgacttgtgc 35880 actgtagaat gtttagctgt attcctggcc
tggccctgct agatgctagc aactctctcc 35940 atcagaatgg gggcaataaa
aaggtctcca ggaatttcca gatgtcccct ggggggcaaa 36000 gccacttgta
gtggtgaacc actgttccag cggcccttcc ttcctggcac atttcatccc 36060
ttaactttct ccaggtcctt cctgtgtgtc tgtggggcaa agagctgttc tggttgggat
36120 aaatctggtt cccataatca cttgggcttg gtaatagtag ctaatactga
caggcactca 36180 gtctcttaag atctcacgtg gactttgaat taaggtataa
attcaggttc cattttataa 36240 atgataatga aacacaggga agtttttcaa
tatttggccc acagaatacc tacttttagg 36300 atcatccggg gaataaatat
ctatttctat gtgccataat tcatatctac ccactaggag 36360 ttcaggcact
tgggaatctg cattttatac tttgcaagtt ctcttttgga atggttttac 36420
attaatgcag ttttcaaatc aaaagatggt gaaagtctct cttactgctc tgctacctgt
36480 ccgtttccct tacccactct ctcccccaac gcacacgcat acaggtaact
agttgcttgt 36540 gtgtccttcc agattttttt gtagctgtat ggtggaattt
aaatttaaca agctcccaat 36600 ttcaaatatg agaaccagtg ctctcaacag
tgctgcttgc ctgctcaaca caaaatgttt 36660 ggaggcggaa aggttttctc
acggtggctg caaaatagag gaattctgga ggcctgatgt 36720 atggattctc
agtgtattgg gtgtcctctt ctctctcacc attccacccc tgggcctgat 36780
taaaggaaga agaataaatt cagatacaaa tagctccgtt tggggagact ggattctcct
36840 tccagaagga tgtaggcagc ttagttattc tgtaaaaatt ctgctacaat
taaggacatg 36900 aaagatgctc agtggcagaa tgaatgggac aaatggctta
gtttcaggca gtctgagttc 36960 tttctagaac tgcttcagtt ttaacaggag
cagttccttg gagctgtgtg gcagcgaaac 37020 ttgtggctag ttgacggggt
ttggctgagg tgacgggata catgaaggct tcagaagaaa 37080 gtataaattc
cataacagta ggatttaatt tctgcaatga tgtcttgggg tcaactgcat 37140
atggaaatgg gtttcttatt ttcttccatg ctttccatgt cttgattctc ccagctggtc
37200 tcagaagtca tcttcattct gcacactcag acttaacttg taatcaggac
tcactgacca 37260 ggtgcacctg acaccacagc tgttttgggg cctccttctg
ctgcaggttt ggatcctgcc 37320 gggcccatgt ttgaaggggc cgacatccac
aagaggctct ctccggacga tgcagatttt 37380 gtggatgtcc tccacaccta
cacgcgttcc ttcggcttga gcattggtat tcagatgcct 37440 gtgggccaca
ttgacatcta ccccaatggg ggtgacttcc agccaggctg tggactcaac 37500
gatgtcttgg gatcaattgc atatggaagt gagttccctc ttttctgctt tgtgtttgac
37560 tcagtttatt ccatctcctt ctaaatcagc cagagccttt agcactgcag
gcactattta 37620 ttcattattc tcacctccca ccacagaggc ctccaatgct
gtatttaata tttctcattg 37680 ttccccaaga ctaaccaacc cagtggttcc
tgctttgctt tctcacgctt taaggtcaca 37740 gttgttattg attaatttct
tttcttttct ttttctttct tttttttttt ttggaaaggg 37800 agtttggcct
cttgttgccc aggtttagat tgcaagggtg caatcttggc tcaccacaac 37860
ttccgtctcc caggttcaaa cgattctcct gcctcagcct cctgagtagc tgggattata
37920 ggcacatgct accataccca gctaattttt gtatttttag tagggacggg
gtttcaccat 37980 gtcagccagg atggtctcga tcttctgacc tcgtgatctg
cctgcctcag cctcccaaag 38040 tgctgggatt acaggcataa gccaccgcac
ccggcttgtt atgataattt ctaaaatgtt 38100 ttttcatttt agggtgcaga
catgaatgga ttaccaacaa aaggaccaac agaaatctgt 38160 gataaaaaga
aagactaaag aaattttcct aaaggacccc atcatttaaa aaatggacct 38220
gataatatga agcatcttcc ttgtaattgt ctctgacctt tttatctgag accggaattc
38280 aggataggag tctagatatt tacctgatac taatcaggaa atatatgata
tccgtattta 38340 aaatgtagtt agttatattt aatgacctca ttcctaagtt
cctttttcgt taatgtagct 38400 ttcatttctg ttattgctgt ttgaataata
tgattaaata gaaggtttgt gccagtagac 38460 attatgttac taaatcagca
ctttaaaatc tttggttctc taattcatat gaatttgctg 38520 tttgctctaa
tttctttggg ctcttctaat ttgagtggag tacaattttg ttgtgaaaca 38580
gtccagtgaa actgtgcagg gaaatgaagg tagaattttg ggaggtaata atgatgtgaa
38640 acataaagat ttaataatta ctgtccaaca cagtggagca gcttgtccac
aaatatagta 38700 attactattt attgctctaa ggaagattaa aaaaagatag
ggaaaagggg gaaacttctt 38760 tgaaaaatga aacatctgtt acattaatgt
ctaattataa aattttaatc cttactgcat 38820 ttcttctgtt cctacaaatg
tattaaacat tcagtttaac tggtagttca ttttctttta 38880 aagtctattg
aaatattcaa aagggaaatt tttcaccacg tcagaaggca gaatttggat 38940
gttatggcat ctgtgtagtg gtgggacaac aattactatt gttgcgtaac aagacactcc
39000 aaaatttagt ggttttcagc agcagtgact cgactgggca gttctttgct
gttctgggct 39060 cactcatatg gctggctggg cctgggtctg gacctgggcc
gctatgtgat ttttatcttg 39120 ggctttgaaa attcagtgta gggacctata
aatattcaaa gatgatgaga tgcatcctta 39180 tatatttttt gtattcactc
tgaagctggg aaagattaaa aggaactcct gcccttgggt 39240 ccctaatgaa
gtctgggtcc taactcgctc tattaagttc tgtggctggt caagtcactg 39300
atctaccttg ggctttattt gatataaatc atataaatca gcaggtctca gcttttctgt
39360 ccaaagccac ctgagggata agataaattc tcattagcaa ataaactttt
ttaaggtata 39420 aatactatta taaaaataac agatatttac agtacaacaa
tgcaagagga tcctaaatga 39480 aaagcgaatg ttttttctca actctcattc
ccttattcca gctccacaga ggtaaccaat 39540 tgtttttttt ttgttgttgt
tgtatggttt gtttttgtta gacagtagtc ttttcctgaa 39600 cagtgctgct
ccttgtggag caaggctaat tcataggcag tgcatccaga gtctgcccca 39660
gttgattttg tgtgtaacct tctagcaact ttttgaaaat taatttgttc ttaaatatgc
39720 acatcatttt tatttattta tgtttttgag acagggtctc actctgtcac
tcaagctgga 39780 gtgcagcagc atgatcacgg ctctctatgg cctcgacctg
cagtcctgaa gtgatcctct 39840 caccttagcc tctcaagtag ctgggactac
aggtgcacac caccatgccc agctaatgtt 39900 ttttgtaatt ttttttatag
agacagggtt tcgtcatgtt gcctgggctg atctcgatct 39960 cctgggctca
agcgatcctc cactttggct tcccaaagtg ctgggattac aggcatgagc 40020
tactactgca cctggcccac acatcatctt ttaaaaatta agtaatattg caacgtttct
40080 aattgtccct acttctttgc tcctcaaagg ttttacctac tgagctgtgg
gctttttaaa 40140 tttatctcca tatttataaa taaattataa aaatataaaa
atataaacat tttatttttt 40200 gagacagggt ctcactgtca cccaggtgct
ggagtgcagc ggcatcatca tagctcacta 40260 cagcctccaa ctcctgggct
caagtgatcc tcccacctca gcctcctgaa ttgctaggac 40320 tacaggtgtg
tgccaccacg cctggctaat tttttgtaga gacggggtct tgctctgttg 40380
cccaagcgag tctcaaactc ctggcctcaa agtgatcctc ttgcctcagc ctcccaaagt
40440 gtcgggatta caggcatgag ccactgcctg gctatactgt tatattttga
gccatcaact 40500 tgagacattg tttcccataa tggttgagat gccgctatct
tacactgcct ctgctcctcc 40560 cacacatcct cccaagtgct tttgtaaatt
ttgcttacat catcagtgtt catagcatga 40620 gtgtgccagg tgtctttcat
ttgcccctcc caagtctctg ctcccctcat cctgctttca 40680 gcccaaggaa
gctgtataga catcaacaga cttcccatgt ctctgggttc tgctgggttt 40740
ggccaatagc gatccatagc aggagatggc tggagggagg agaatgaagg cagagtgttt
40800 attcccttgg ccctctctct gcaaggtcac ctcaggccaa ctgttcctca
gccagaagtc 40860 actgtgcctc aaggaacact ccaggcagcc aactccacct
gacttctttt atttttccta 40920 acctgtcctt caccctgccc ttttgggccc
aggggtggtg gtatttctgt tactggctct 40980 gggctactgc ttcctctcaa
gagtgctatc tggcttgctg ggacactgcc tgggagaata 41040 ctattgctca
ctgcacaggt taatgcactg tgattgcctc ccttttaata tacaggtggt 41100
gtcttcctgg agtgaccagt ttaccttctc cccatacacc tctcctgcct agttgttgcc
41160 tagacctggt gcacactgca gtcctcggga ctttctgttg ccaccctcct
gtattggacg 41220 tcttgtttct ggatttccta tcctcttcct tcttggttta
tccctcattt tttctgtagc 41280 acagcagttt tctaattcaa tacttttagg
aggttgagta tggataattt tggaaagtgt 41340 ccccgggatg attccaattt
atttaagcct gttttccaga gagctgcggg tctcctaagg 41400 cctttctcat
ttctaacaag tctccctctc tagaacactg gttcccagtc gttgttttca 41460
tactagcaac attttaaaag caggataggg gtggctagta tgcaattgcc aactttggat
41520 ttttccaagc aggagtatat caaaaagcta caatttatta ccagtatttc
gtaaaagaca 41580 gtttgacacc agaagagtga aaaagaacat gggaatagtg
gacaaaaata gccatcagtt 41640 tgaataagcg tatgaaaagt gttaatttta
tgaaaaattc actattttgt tcatattttt 41700 cttattttgg aggctaattg
ttaaaagctt ttatcagtta tccatgggct ggagttggta 41760 gccactgttt
gataccacac aaatgtttct ttgccctaaa atatcaacat ctgtctgtgt 41820
aaaggtcagg gctgcctttt tagtaagagc taccctttgt taaacacatt gtacctgcac
41880 tgttcatggg tgtttcacac acacaaacct acctggtctg cataaacctg
aaatacagtc 41940 aagaaaacag gatccaccgg aggcggtgac tcaagcctat
aatcccagca ctttgggagg 42000 ccgaggtggg aggatcactt gaggccggga
gttcaagacc agcctggcca acatggtgaa 42060 accctgtctc tactaaaaat
acaaaaatta gtcgggcata gtggtacaca cctgtaatcc 42120 cagctactcc
agaggctgag gcatgagaat cgtttgaaac caggaggcag aggttgcagt 42180
gagctgaaat tgtaccactg cactccagcc taggtgacag agcaagactg tctcaaaaga
42240 aaagaaaaag aaaaacagga tcccagcctg ggcaacatag ggagacctcg
cctccaccaa 42300 aaattaaaaa tttagctagg catatggtga tgtgcacctg
tggtcccagc tactctggag 42360 gctgaggtgg gaggattgct tgaacccagg
aggttaaagg ctacagtgag ctgtgatcaa 42420 gccactgcac tctagcctga
gcaacagagc aagaccctgt ctcaaaaaaa aaaaaatcac 42480 tattgcccca
gcaatggatt taatttaatt taattttaat tttttttttt ccggaccggg 42540
attttggctc ttgtaccgca ggtgggagtg caatgggcca atcccagctc acgggaattt
42600 ccgcccccca ggtccaagca attctccttg cctcagcctc ccaagtagct
gggattacag 42660 gtgcccacca tcacacctgg ctaacttttt gtatttttag
tagagacagg gtttcaccac 42720 attggccagg ctggtctcaa actcctgacc
tcaggtgatc cacccacctc ggcctcccaa 42780 agtgctggga ttacaggtgt
gagccaccgc acctggccct aaggagtaca ttttattagc 42840 attttagttt
atttaatatt cattgttcta tttaaatttt cttattctaa ttgtgacgtt 42900
ttacattttt tcagttttta tacaggtttt gaatttatat ttcataatat ctattagcat
42960 gatgactttc acatttatac cttttattca gatggaattc atttttgttt
tgggggggtt 43020 gatggtttta acttctactt tagtttcagg ggtacgtatg
caggtttgtt atgtagttaa 43080 atggtgtgtc acaggagttt gctgtacaga
ttatttcgtc actcaggtaa taagcatagt 43140 acccaatagg tattttggaa
ttcatctttg ttgcgtgtta aaataggaat ctaattttgt 43200 ttctctttgt
caaatgagcc tactttctca tcatccatcc attcctttcc caaagactaa 43260
taggcccctt ttatcataca taaaatttcc gcatatatgt ggaaaggatt ttattttatt
43320 ctattctatt ttattttatt ttgagatgga gtctcactca gttgcctagg
ctggagtgca 43380 gtggcgtgat ctcagctcac tgcaaactcc atctcccagg
ttcgagcgat tcttctgcct 43440 cagcctccgg cgtagctggg actacaggca
cgtgccacca cgcccagcta atttttgtat 43500 ttttagcaga gacgtggttt
caccatattg gccaggctgg tctcgcactc ctgacctcgt 43560 gatcctccca
tctcagcctc ccaaagtgct gagattacag gggtgagcca ccgtgcccac 43620
ccaggatttt atttttgtct cacactgtcc tcttatcaat tcaaatgttt acaaaacaca
43680 aatactttct tttttaccat gtacctttaa cattcacaac aaccctgagc
agtattgtct 43740 ctgtttctta aatgagcaga tagagactca gaaaggctgt
atttagccta aaactcacat 43800 aatgctggat gacacaccaa gaattctgat
tccaaactaa ctgctctttt cccagattac 43860 ctcctgcctg tttaagcacc
tagtttctta tatctaattt catctattta tttaaatatt 43920 cattgaatac
ccatgatgtt ccagacacta ttctagcttc taagataacg gcagaaaaca 43980
agccagataa aaatctgtgc catcagagag cttacatggc agagggctca gggtagctct
44040 gaacacagag gtgacacctg agaaatacca tatttgatga caaagactgt
tctagtacct 44100 actttgtatc catccttcca aggggtctgg ggcttcagct
tgtttggaga gtcaaaggaa 44160 gtcctgtgga agttcccctg actctaacta
gtaactgaac ccccaagcca aagaaggcac 44220 ttgcagtcat ccaggctatg
actcttcctt tgggaaattt caacaatttt ctttactatg 44280 ccagagacac
cattttctgc tttcctctga catctgaacc aagttaagaa cttatctctt 44340
attgtctaac ccaactccct acagccatta tcaagcctgg tttcagaatg tcctggtaga
44400 gatggacagt ggagtttcca ccatcactaa agccctttat aaagagcttc
cttgtcattt 44460 agaaatgttt tcacacttaa gaccagaaat aaagtcaaac
tgatgtaatg cattatactt 44520 catagtcata gatcaattta agattactaa
aaattgacta caggatttaa tcatttaaag 44580 ggtactctgg tctatctcgc
tggctttagc agagaaaaaa ctaattcctg ataaacggat 44640 ggcaagatcc
aatttccctt ttaataaata gtaattggta gggggaaagg ggaaataggg 44700
acggaattgt taaaagatac aaaattacag ctagtggctg ggcccggtgg ctcacaccgg
44760 taatcccgac agtttggaag gctgaggtag gtggatcact tgaggtcagg
agttcaagac 44820 cagcctggcc aacatggtga aaccttgtct ctactaaaaa
tacaaaaatt agctgggtgt 44880 ggtggtgcat gcctgtaatc ccagctactt
gggaggctga ggcaggagaa tcacttgaac 44940 ccaggaggcg gaggttgcag
tgggccaaga tcatgcccct gcactccagc ctgggctaca 45000 gagcaagact
ccatctcaaa aaaaaacaaa aaaacaaaaa acaccaaacg aaacaaacaa 45060
gattacagct agacaggagg aataaattct agtgtcctat accactgaag ggtaaaacta
45120 gagttaataa aatatggttt caagtaacta gaaggaggat attgaatgtt
cccaacacaa 45180 agaaatgata catgtttgaa aggatgggta tgctaattat
tccaacatga tcactatacc 45240 tgtatgtttc gaaacatcac tatttnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 45300 nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 45360 nnnnnttgct
gctaaaactg aggtgtaggg cagtgaccaa ttttgggggg gtttcttatc 45420
cttttactgc cttggctgct gacagcatat cctgtcttga ccccaggcag ctctctccac
45480 tctgatgctg tgccctccac atgtcctgcc ctgatgctca gtctttccct
ctcccggttt 45540 aatccaagta gctctgcagg gtttggaggt ccatgcaagg
ggattttact ccctcctcag 45600 aatataggat gatggccttt ctttcctttc
ctttcctttc ctttcttttc ttttcttttc 45660 ttttcttttc ttttcttttc
ttttcttttc ttttctttac tttacttttg atggagtttc 45720 actcttgttc
cccaggctgg agtgcaatgg tgtgatctct gctcaccgca acctccactt 45780
ccaggttcaa gtgattctcc tgcttcagcc tcccaagtag cagggactac aggtgcttac
45840 caccatgtac agttaatttt ttgtattttt agtagaggtg gagtttctcc
attttggcca 45900 ggctggtctc aaactcctgt cctcaggtga tccacccacc
ttggcctccc aaagtgctgg 45960 gattacaggt gtgagccact gcccggctgg
atgatagcat ttcttaaggc tgctggtgcc 46020 aatgaggcag ggttggggtt
ggttatgcca aattttttgt aagatcccag aaattatttg 46080 ggccagaaaa
tccaaattgt atgcctaact ttgtaaccaa ctgtctctat gaccctgagc 46140
agattacctc acccctatgg acctttgggt cataatcttt aattgaaggg attagactag
46200 aatgaggttg tcaaacatct tcttaaagca tcagctagta aatgttttag
gttttgtggg 46260 ccgtattgcc tctgttccaa ctctgctgat gtagcatgaa
agtagccatg acaatatata 46320 aacaaatgag ggtgactgtt ccaataaaac
tttatttaca aaaacaggtg gccagcaggc 46380 atggtgtggt gcacctgtag
tcccacctat ttgggaggct gaggcaggag gactgcttgg 46440 gcccaggtga
ggatcacttg agcccaggag tttgaggcca gcccaggcaa cataatgaga 46500
cactgtctat aaaacaaaaa caaaacaaag caaagaaaaa aaaaagaggt agcaaacctg
46560 caagccatat tttgctgagc cctgcgtgag atgatgttta ggatctgatc
catttgcagc 46620 attctgtggc tgtatagccc tattaggagg tagtgactcc
tgctgcacag ctggtctgca 46680 tcaccctact tagcacttat tatatgggcg
ttcttgctct ttattgcttt gtgtgtattc 46740 gtgctgtctt cccatcaaga
gagtgaacag ttaggcagca tgaatggcct taaattcctc 46800 tacatcttaa
tgggaaccta gcaccttgct ggacattaat gaagcattac acaggtcggg 46860
tgcagcggct cacatctgta atcccagcac tttaggaggc gaaggtggga agattgcttg
46920 aacccaggag ttcaagacca gcctgggcaa tgtggtgaaa ccctgtatct
acaaaaacta 46980 caaaaattag ccaggtgtgg tggtcatgtg cctgtcgtcc
cagatactgg ggaggctgag 47040 gtgagaggat cacctgaatc tcggaagttg
aggctgctgt gagcgggggg tcgtgattgt 47100 cccactgcac tctaacctgg
gcaagagtga gaccttgtct caacacaaat aaacaagcaa 47160 aagaattaca
tgaaaatact aacagcaaca ataaacagct atcactgttg aggagtacag 47220
tatttattat ttgagtgtct aatcatcaag aagggctcat cctgcatgct ttttatctct
47280 cccaccccca gcaatcacag aggtggtaaa atgtgagcat gagcgagccg
tccacctctt 47340 tgttgactct ctggtgaatc aggacaagcc gagttttgcc
ttccagtgca ctgactccaa 47400 tcgcttcaaa aaggggatct gtctgagctg
ccgcaagaac cgttgtaata gcattggcta 47460 caatgccaag aaaatgagga
acaagaggaa cagcaaaatg tacctaaaaa cccgggcagg 47520 catgcctttc
agaggtaacc ttcagtccct ggagtgtccc tgaggaaggc ccttaatacc 47580
tccttcttaa taccatgctg cagagcaggg cacatcctag cccaggagaa gtggccagca
47640 caatccaatc aaatcgttgc aaatcagatt acactgtgca tgtcctagga
aagggaatct 47700 ttacaaaata aacagtgtgg accccttttg tgatgtggct
atcagtccat gatcacaata 47760 tcaatatctt aaatttctat cttgcattta
actttcaaag ctgtttcata tttgttttct 47820 catttgatca tcacaagaaa
cctgaggcag atgaacaggg gaccaaaatg acatgttaca 47880 tttttataat
gtgctgtaaa atcacaaggt tttctgggta ctgtgggtat tattttacat 47940
atgaggaagt tgaggctcag agaggttaat accttggtcc ttaatccagg ggcacgtagt
48000 tagaaagtag ctaagtgaaa atcctcaaaa gatctaactc ccaagtgcag
ggctccttcc 48060 atactgcagt ggcctcttat ggcattggac agaacaagag
cagatggggg ctgcaggctg 48120 ggctcaacca aaagaacacc agccctaaaa
tctctgtgct ggtgactcag tttgggtcag 48180 gggtctcctg tgatgacaag
caagggttac aagcatcttt gttctgctgt cactgcagtt 48240 taccattatc
agatgaaaat ccatgtcttc agttacaaga acatgggaga aattgagccc 48300
accttttacg tcacccttta tggcactaat gcagattccc agactctgcc actggaaatg
48360 taagtcatcc gtttcccttg ctgggttcgg gacagagaac aggttggttt
gagaatgaga 48420 gagcacaagg gagcgtgtga acgagtacag cacgcaggag
agtgcagtcc gactgctcag 48480 ggaggagcca ggtggtctag ctggcctctg
cagtcctctc tcccactgca ccttctctac 48540 caagccctga ctcagcgttt
cggggagaaa agttcctggg atgaatcggc atcatgagaa 48600 gctgctgggt
cagcagctgg atcagctggg cagaaactgc tgtttcattt caggcaatgc 48660
ctgacgatgc ttcaggcaat ctgtaacttc gtaaacgtca tcctggacct ctcctaatga
48720 tgtggctatg ggaggggtgc atagcgatct gtatatgttt gttgagtatc
caccagggac 48780 aaagcatcat gccaagtaat gttgggattg tgatgaaaca
tcatcaaagt agctcacttc 48840 tcagggctca cagtctagct gggagaccag
gtttgtacac gcacgtgcac acttacacac 48900 aggtagggca aggcagatga
ggccaagcca aatgagaggg acagacagga agaggctagg 48960
agtttggggg agacagatgc ctgtctgtgg gatggatgag gtctgtgggg ggagctggtt
49020 ttccccagca tctgattttc agagcatcat taactctttc cttcagaggt
tctaaggctg 49080 agcggaacag cgcacttgag tggggatgtg acttctttgt
gttttcttat tgtgttcttt 49140 cttggttctg tcttttcagg aagtagcata
agtggggtgg agggggtgcc caggaatcgt 49200 tttgataaga agctggggtg
ctgagggcaa agttagtttg gcccatatgg agtacacctg 49260 agcttccatc
ttggtcctgt tgataggaag tagagggata gaggtgggga aagcactcac 49320
actgtctctc tcctgtctgt gtggggttgt tactgccact gtgtcacccc acacagtgtg
49380 gcagttttcc agctgttagg ggagtgagat cagcttctct cccacttgta
gagtggagcg 49440 gatcgagcag aatgccacca acaccttcct ggtctacacc
gaggaggact tgggagacct 49500 cttgaagatc cagctcacct gggagggggc
ctctcagtct tggtacaacc tgtggaagga 49560 gtttcgcagc tacctgtctc
aaccccgcaa ccccggacgg gagctgaata tcaggcgcat 49620 ccgggtgaag
tctggggaaa cccagcggaa gtaagtgcct cctgctcctt cttctgcctg 49680
gtgtaggtgg ggaacagaag gctgtgcctg tgacatttcc tttcctttgc tgcatctacc
49740 ctcaatcctt ccctccagca tgcaggtaaa acttcaaaca cctttgcaag
gacaagtgac 49800 ttccagatca aggcttctat caaaactgtt acgcatctca
tgccctgaac atgggccctc 49860 agggagacgg gtgggccagt ggaggcagta
attcagccct ggctctgttt gccaggcctt 49920 gtgtcagcct ggaggagggg
gacttctcct ggactgggct ttttaggagt gctgccttgt 49980 cgatgtgttt
actgtggggt ccatgcagac aaaaggcttt gcttgcttct gagcaaagca 50040
gactggagta tcacttccag agagccccca tggatgaggt ctgtgggagg aactggtttt
50100 ccccagcatc tgattttcag agcattattc tctctccttc agaggttcta
agtcaaggat 50160 gtggggctgt ggtcctaact gcaagtaaca gagaatcctc
tgtgccacac tagctggcag 50220 tttcccattt cttttaaccc caagcctagc
ataaaagatc cagatctttc tatcagctcc 50280 taacaccgtg cctggactcc
ctgagcaggc ttttttctaa acagaagcca gggaagcctg 50340 cgagaccttt
gtcaagaagg gagagtttcc ttaaccaagt ccttcagctg acctctacag 50400
aggtcactgc cagccttggc atgggaggag gcagctgcct ccctctttgt ccctcctctg
50460 gcattttctc cattataatt cctgccatgt ctggtttaca ttcgtcatct
atgacacagc 50520 ttggcagcag agggaagtga agtggaggct tggagccctc
agctgaatga ttctagtcta 50580 gaaacctgtg aactgggggt gctggcctgt
ggtctagact gtgtatgttt ttacttctct 50640 gggcccttgc aggtacaaac
tatacctatg gatgtgagag cagaaagatg atcatttata 50700 aataaaatat
ttcaaagaaa ataaacacct attaaatcac cattgagact cacaaatgta 50760
aatagttttc catttgggtt tagatatcag atttttaaaa agtaaaacat tatagataca
50820 gttgaagccc ctgtgtcctt ctctgctcta cccttcttct ttcaaaccaa
atataactaa 50880 tatttcaatg ttaacaaatg ttagtgtgtt tccttccatc
atgtttttat acactttgta 50940 cttactgttt tttttgagac tgagtctctc
tctttcatcc aggctggagt gcagtggcac 51000 aatcttggct cactgcaaac
tccgcctccc ggattcaagt gattctcctg actcagcctt 51060 ctgagtaact
gggattacag gtgtgttgcc accatgccca gctaattttt gtatttttat 51120
tacagacggg gtttcgccat gttggccagg ctggtttcag actcctgatc tcaggtgatc
51180 tgcctgcctc agcctcccaa agtgctgaga ttacaggtgt gagccaccat
gcccagccgc 51240 cttagtactt ctgtctgtgt acataaacaa tgtatagaat
tttggatgct tctgaatttt 51300 acatgagtgg acataatatt ttacaatttg
attttttcat tctaatattg tttgtgaaat 51360 ttatccaaaa cataaagatc
taatctattc ttgtttaact cctgtatgta aatcaccatt 51420 gcacaaatag
ttttgccatt gttctgctga atagttgagt tgttgctttt ttgtagttac 51480
aaatggtgct gagatgaaca tcctctgcat tttccttgtg cacatgtgtg taagggctgt
51540 ttctcagcat gtgttctaaa aagtggaatt gctgggttgt agtatatgca
ttctccagct 51600 tgaacagata ttgttaaatc tgtctccaaa gtggttgaac
taattttcca tcttaactat 51660 ggatgaagag ttcccttttc cctccttttc
acccaggtct ggtgggacat tcttgtcatt 51720 ttgttaggtg tgaatgggcc
ccctgctgtt gtttgaattt gcatttcctg attgtgcgtg 51780 agataggtca
tgtttttata tgtgtataaa catataggtc ctaaggtcct tagggcttcc 51840
tgggaaaggt tcttaagctc ttctgaatgg ggcttttgtc ctgcctcagc tccagggtca
51900 ggtgccccac acccttaagg attacgtggt cacgctaatc acacgcccct
gaggctgcgt 51960 ggggcagcca taagttacat ggaaatggtt attaggccct
gattctttct tgtggtcttg 52020 gctgtccatt tgctgaatct ttggttttga
cttgcagctg agttgcagtt gnnnnnnnnn 52080 nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 52140 nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nccagcagca gcggaaagaa atatcctgga 52200
ggaagttgaa ctttaccctg cttgggaatc tatccaggtc tgaagcccct ctaccgaggt
52260 ccccagaatg ttccccgctt tccccactga gtctgctggg gagtaaagtc
caagatgaca 52320 gctcagttgt tcccacgtgg cagtgtcctc tgagggatcc
aaataaacct ggagttttat 52380 tatcctgact gtgccgataa ggagactggc
cgacctaggc agagaaagtg gaggccactg 52440 tccggtatct cttggcaggt
cacactcatt ccttttctgt tcacatcagc tgggcttgta 52500 acagctccca
gtgatagcgt atccaggctg gtcacccgac ggtggagtct tgtccatttg 52560
gaaggcccag accaatgact gaagtaaact actcacccca caatttactg ctcctagaac
52620 aaattgcttg tcttggtgat aattctcttg tgtatggctg aaactatcag
ctctgggata 52680 atgtgcataa ctttgcatgg attgataaag ctccatttat
ttatttggct aaacagagtt 52740 attacactat tacttcttct atgagtttct
gacataaagt cagacaaact caaatgcaag 52800 cttatttatt tatttattta
tttatttatt tatttattta tttatttatt tttgagactg 52860 agtcttgctc
tgttgcccag gctggagtac agtggcgcaa tctcggctca ctgcaagctc 52920
cacctcccaa gttcaagtga ttctcctgcc tcagcctccc gcatagctgg gattacagat
52980 gggcaccacc acgctcggct aatttttgta ttttttagta gagacagggc
ttcgccatgt 53040 tggccaggct ggtctcgaac tcctgacctc aagcgatttg
cccaatttgg tctcccaaag 53100 tgctgggatt atgggcatga gccaccatgc
ccggcctcaa atgcaagctt ttctatcatc 53160 atactaatcc tgctgaatga
atttggagct caattcctat gggggggcaa gagcctagag 53220 gtcaaagctg
tcctcttgaa tcctggtgtc gttgatgcgt gcataaggct ttgcttgttc 53280
atactctctc aggcagaagt gtaatttgag gaaaatgtag tgtgcatgtg tgtgtgtgca
53340 catgcacatg tgtgcataca tgtcctataa gaatgagaat gggtgcccac
ttttcttggc 53400 tcctctccct tgtgcctctg ggcctttctg cctgaatgca
cttgcctgga aatccttgtc 53460 gatctctctc attcaatgac cagagcacca
actatggagt ttggaaacct ggctccagcc 53520 ctgattctgg cattgacatg
ctgcataaca ttggtgaaag caactggcct ctttgaacat 53580 cccttcctgg
tgtgtggcag gaaacatttg gtttccttga actgaacccg cctgacaatg 53640
ggaagatttg cctgaaccac ctcccctgct gggtagctat agggattaaa tgatgtaaca
53700 gaaggtaaag caggattatt ttttaaactt ttatctattt ttaatgccct
cctatgtatc 53760 ttcaaggcca gagccttctg agacactcca gcccacggtg
actgctctcc tcttatctgt 53820 cacttcttta gccttatact gctttgctta
ttatgatcta tttatgtgtt gcgctttatc 53880 cacttgtctt gtccataagc
tctttttctg cccttttgaa tcttttcagt ggctagtgtg 53940 ctgccttcat
cataactgat ttcagtatgt ctttccagat tgactactta attgaatttg 54000
gaatatgggg aaggagactt agtgtaaagg gaccacccaa tacaaggtct gagattattt
54060 tatgccatat ttcatggtgg aataaggaat gaataacaca atctgaatga
ataatgcagt 54120 gtatcatgag ttgggaaggg agaaaaaaaa gagtatttgt
acatgtcatt ttttctttct 54180 ttcttttttt gtttttttga gatggagtct
tgctctgtta cccaggctgc agtgtagtgg 54240 cgtgatctcg gctcactgca
acctctccct cctggggtca agcgattctt ctgcctcagc 54300 cacgcaagta
gctgggatta taggagcacg ccaccgcacc tggctaaatt tttgtatttt 54360
tagtagagat ggggtttcac cgtggtggcc aggctggttt caaactcctg acctcaaatg
54420 atccgcctgc ctcagcctcc caaagtgctg ggaatacagg catgagccac
tgcgcccggt 54480 atatacatgt cattttcaat cattttgacc tgaatcacct
ggttttatct ggtcaatgaa 54540 agcagaggac aatggtcaaa cttactattt
gggtcttttg agacaaagta accagctgat 54600 cgactgtctt ttctgctcag
cagaacttgc tggccctgga agccatgagg agtaactgaa 54660 ctgaggcgaa
taggctcata gctggggagg aaacagcaac atagcaacat ttttactttt 54720
gccttattgg tgtaaccttg ttcacaagga agacatggaa gggaaaggac ttggagagtg
54780 agagaggaaa cagaaaagaa agattgtgag gaagggccag gaggaagcaa
atagagcttc 54840 cagttcatgc ttggggagta ctcaaagtgt ccatgggaga
gctacgggtg gttgcttcat 54900 atgcagggag aggcctggcc agacccacct
tcctcccagc tctgacccca gagtgaggtc 54960 agtgtccagt ttccacgtga
acgatttgca gaccccaccc tttccccagc aggtagcaaa 55020 ggccacctca
cttgtgtcta tgcacaagcc tgggctcaga gattctctca agccctagtg 55080
tcagtgctct ccagatcaag aggaccaaca gagtatatat ctatagagaa gtttatttta
55140 aggcattggc tcacgtgatg atggaggctg gcaagtccaa aatctgcagg
gtaggcctgc 55200 agcctggaaa cccagtgaag aattgcagtt tgagtccaaa
ggcagtctgc tggcagaatt 55260 ccttcttgcc cctgagcaag aaggaattat
tttctatgca ggccttccac tgattggatg 55320 aggcccaccc attcaatgga
gggtcatcta atttactcaa agcctattga tttaaattta 55380 atctcattcc
agcactttgg gaggtggagg tgggtggatc acttgaggtc agggagtcga 55440
gacnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
55500 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnttttcaa
aaaaaaaaaa 55560 aaaaaaaaaa aagaaccatg tcttcatgaa gcttacattt
tttgaaaagg agatagaaat 55620 ttaagaagaa aactaataaa tgtgataatt
tcattcagtg agatatgttg tgaagacaat 55680 aaaacaagat tatgtcagag
aggagctcca tagactgagt gtcagggaag gagttaaggc 55740 ttcagtgact
ggaagaagcc aacacgtgaa gacctagttg taaatcattg gaaggaaggg 55800
caaaagcaaa ggcatcaaga caggaatgag ttgactgtat ccctgaagca gcaaggagcc
55860 aatgtggctg gagcaaagtc agtgcagagg aaaagtatag gaaatgaggg
cctggagcta 55920 gatcagcctg cacagcacag taagcagttt ggactttatt
gggtgtgaaa tgtgaagtct 55980 ttcaagggtt ttaacctggg aagtgctttg
gagagaagtg gggagtgtta tattatatag 56040 tttatatttt ttaaagatta
cattttctgg ttatagttat catagttcta gaaactgtat 56100 tttaggacaa
ccaaatcacc ccagttaata agagaaagct ctttttacaa agaatgccaa 56160
gctattcaga ttaaagaaaa ataaagagac atggcaacca aacacaatgc cttattctga
56220 atttggctct tcgtccaaaa aaaattctat aaaagatatt gttgggaaaa
ttggcggcaa 56280 ttaaatatgg tctctaggtt agataatatt attatagtaa
atgttaaatt ttctgattct 56340 aaaactgatt atgaaagaga acaacctggc
caggcacggt ggctcatgcc tgtaatccca 56400 acactttgga aagccgagac
gggcagatca cctgaggtca ggagttcaag accaacctgg 56460 ccaacatagt
gaaacccagt ctgtactaaa aatacaaaaa ttagccaggc gtgatggtgg 56520
gcgactgtaa tcccagctac tcaggaggct gaggcaggag aatcacttga accccggagg
56580 cagaggttgc agtgagccga gattcgcgcc aataccactc tagcttgggt
gacagcaagc 56640 ctcctgtctc aaaaataaaa ttataagaaa caacaaccag
atgtcatgtg ggacctagat 56700 tgggtcttgc tttgtttctg gtttttttgt
gtgtgtgtgg ctgctttggt tggttggttt 56760 gtttgtttgt ttgtttgttt
gagacagagc cttgctctgt cacccaggct ggagtgtagt 56820 gacatgatct
caactcactg caacctctgt ctcccagctt caagcaattc acatgcctca 56880
gcctccagag tagctgggac tacaggtgtg tgccaccaca ccctgctaat tttttctatt
56940 tttagtagag acagggattc accatgttgg ccaagctggt ttcgaactcc
tggcctcaag 57000 tgatctgcct gcctcagctt cccaaagtgc tgggattaca
ggtgtgagtc agtgtgcctg 57060 gcgggtcttg ctttgaacaa accaactgga
aaggacattt ggggaacaac tgggataact 57120 gaaattgagg ttaggtatta
gaagagatga aaatgtatca acatggtaaa attgagatta 57180 actggaaaaa
aatctgatta tgaaatagca tgtacagtat aatttcacct ggtaagtata 57240
tatgtatata catacacaca tgaagtatat atctcacact atactagaag gatatattaa
57300 agcttaatct tttggaaata taaggatttt attttcttaa tctgcttacc
tgctatatct 57360 gactttctat aaaacacata taaataatct taaatttttg
aataatttta aaattttact 57420 tattatttat ttatttattg agatggagtc
actctgtcac ccaggctgga gtgcaatggt 57480 gcgatcttgg ctcactgcaa
catctgcctc ccgggttcaa gagattctcc tgcctcagcc 57540 tcccgagtac
ctgggattac aggcacgcac caccatgccc ggctaatttt ttcttttctt 57600
ttcttttttc tttttctttt ttttttttga gacagagact cgctctgtca cccagactgg
57660 agtgcagtgg tgcgatctcg gctcactgca acctccgcct cccaggttca
agccatgctc 57720 ctgcctcagc ctcccaagta gctgggacta caggcgtgtg
ccaccatgcc cggctaattt 57780 tttgtatttt tagtagagag agatggggtt
tcaccgtgtt agccaagata atctccatct 57840 cctgacctcg tgatccacct
gccttggcct cccaaagtgc tgggattaca ggcgtaaggc 57900 atcttgcctg
gcaacttttt ctatttttag taaagacagg gtttcaccat gttggccggg 57960
ctgatcttaa ctcctggcct caagtgatct gccaccccgg cctcccaaag tgctggggat
58020 acaagcgtga gccaccgcac ctggccaatt ttaaattttt taataaataa
attgctctgg 58080 ctgttctaga tggattacag gggcaatcaa gagtggaagt
aggttgtcta gttgatcagc 58140 aatatgcttt tcagtatctg tttcccaagt
ctaggtggaa gccagattct tgctggaaat 58200 gaagcttctc cttcatggga
atcccacata catggccaaa gagatcttac gtctgggagc 58260 acaaactggg
tatgttaaag ggcttgatat tctccagggt attttgttgt ccaacaaagc 58320
tgggtagaga tttgcacagg tccacggagc tgctcagcaa agggagggtc tggaggagtg
58380 ctatccagca gactaaaggc aaggcaccag ccctctttga agttatacac
tggtccagcc 58440 agggaaatca caagcacaca cacataccca acatcagtta
atgacaagat aagaaagaaa 58500 atgtactttt aaatttgatc ttaaaacaat
tcacaactct taaaaattat gcagaataag 58560 ccaggcgtga tccaccaagc
ctggtccatg attaatagta aatgtgaagc atccggccac 58620 aacacgtggt
ataggctgaa tatccctaac ccgaatatct gaaatccgac atgttccaaa 58680
atcgaaaact ttttgagaac caacataaca ccacaagtgg aaaattccac acctgacttc
58740 acatgacagg tcacagtgaa actgcaggtg cacaagccag tttatttaac
atacccannn 58800 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn 58860 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnngcc tctgttattg cagctgaata 58920 accatcccaa agtcaagcaa
tattgtgtgg gattctggag aattgagaaa tagcaaaata 58980 atttttgatg
gaggcagctg gcagggctag ccctgcctgc aaagttgtcg gaaaggacag 59040
gtcccacggg aaagagtagc aatatgagat agtgccaaaa ctatggaatt tgaagtcaaa
59100 tgagctgagg tttccacact gacgtctttg agcaattact tcacctctct
cagccagttt 59160 cctcacctaa aatatatgca tgatgatgat tctgccatta
caggaaatgt tgacatgact 59220 gtagtaataa caattcacat tatggattat
tttctatttg ccatgcacta ttatttcgca 59280 aaatgaccct atggaacaga
tagcaccgtt attcccatta tatagtcaat atgtgccagt 59340 gtactctgta
aagtactata caaatattag gtattctttt ctagcataga ctgccagtaa 59400
attcactgag cttgcagaat tatgacagga aaacatatta aaacccaaag tagactgggc
59460 cctgtggctt atgcctgtaa tcccaatact ttgggaggct aaggtgggag
gatcacttga 59520 gcccaggagt tcggaaggac cagcctgagc aacatagcga
tacactgtct caacaaaaaa 59580 tacaaaaatt agctgggagt ggttggcaca
ccctcggtcc cggctactcg ggaggctgat 59640 gtgggaaaat cgcttgagcc
cgggaggttg aggcttcagg gagccataat ctcaccattg 59700 cactctaccc
tgggcaacag aacgagacac tgtctcaaaa aaaaaaaaaa cccccaaact 59760
acctaactaa aaagccatag acactactat gcagtcattg taaagaatgc tatggatgca
59820 tatttatttg aaaacatttt catgatacac tgagtggaaa catatatagt
atcaaatttt 59880 cataagtgaa ttatattagg ttggtgcaaa actaattgtg
gttttgccac ttaatataat 59940 atttatatta atatattaaa tgatatatta
atataacata tgtaatatat gtttactata 60000 atatttataa tacctatgta
tatgtgctgt tggaaaaaag acaaataata ttaacaatat 60060 tgcaactttg
ggtaatgaga tcctgtgtgg ttaaaattag tttttcccta tgttttctaa 60120
tttttctgca aggaatatga agtacatgta caattttatt ttaaaattac agcaaaaaga
60180 gactcagggc tgggcgtggt gactcatgcc tgtgatccca acactttggg
aggccgaagc 60240 aggcagatca cctgaggtca gcagtttgag accagcctgc
ccatcatggc gaaaccccgt 60300 ctctacgaaa aatacaaaat tagccaggca
tgcgcctgta gccccaacta ctcaggaggc 60360 tgatgcagga gaatcacttg
aacccagacg gtggaggttg ccacgagccg agatcatacc 60420 cctgtactcc
agcctgggtg acagagccag actctgtctc aaaaaaataa aaaataaaaa 60480
aagagactca ggcatgaaaa cctaactcaa aatatttttt aatattgcct ggcacacagt
60540 ctactttccc cagactgact cagcaacagt tgtgagcatc tcctcaaaac
tggctttata 60600 gacctaagaa gcaaaatatt ttatttcaag gggatcctat
tagtgaaatt ttacatcgtc 60660 tccctttggt catttttgga tgacttgaaa
taaacagtct tgcctgtgtt cctaggcaaa 60720 tgttataatg ttgctaggca
aatatcataa atcggaagat aagattagga atatttttta 60780 ctacgtagga
agtgttgagt tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 60840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
60900 nttacctccc ccaagacctc accctttttt tttttttttt gagacagagt
ttcactcttg 60960 ttgtccaatc tggagtgcaa tggcactatc tcagctcaca
gcaatctctg tttcccgggt 61020 tcaagcgatt ctcctgcctc agcctcctga
gtagctggga ctacaggcgc acgccaccac 61080 gcccagctaa tttttgtatt
tttagtagag acggggtttc accatgttgg ccaggatggt 61140 ctcggtctct
tgaccttgtg atctgcctgc ctcggcctcc caaagtgctg ggattacggg 61200
cgtgagccac cgcgcctagc cctggtttgg tttttttttt tagagacagg gtctcgctca
61260 gttgcccaga ttggagtgca gtggcatgat catggctcac tgcagctgcg
atctcttggg 61320 ctcaagcaat cctcctgctc cagactccca agtagctagg
actacagctg tgcaccatta 61380 cgcccagcta tttttttggt agagatgggg
gtctcactat gttgcttagg ctgagctgga 61440 actcctgacc tcaagtattc
ctcccttctc agcctccaaa actattggaa ttgcaggcat 61500 gagccactgc
acctagcccc catgttaact attattagtt tgtgactttt cctaatttgt 61560
cccagacagg aaggagacag tgacagctgc actgtgcccc ctccctaagt tctgccatca
61620 gaactgctcc tctgacatct tttctgatgg ccagaaggcc accaggaccc
atagtgatca 61680 ggctgtctca acctctttcc ccaggctagg ctaagggctc
aggaaaagga agaatgaatg 61740 ggggctctgt agagtgcatc taagctctcc
tgcatgcagg agggactgga gaacgaactg 61800 tgtagcttct taccttatca
ggcaggcaat acccaggaat gctggagtca ctgcttttgg 61860 agcattcaaa
ctctctgcag cactttctga gtcttgctgc taacagctgg ccttgcaagg 61920
aattcattac catagcacca caggaggcct tagaggacgc cggttcagga gcttgctcag
61980 tcatttgtgc agctcactgg ctgtgcatct ctgtcggaat cctctcatgt
ccctagaact 62040 caaatcacta acattcccta cgctgttgta actttatttt
actacctgtt cagccagcct 62100 ctgcttgaac acatgcagtg attgggatct
catttctctt ccacatagac catttcacta 62160 ctagtaagct taatttcact
gaaccaccta tggtgaagtg attcctgagt cattaaataa 62220 ctttctactg
caccctttct catagggtta tttggagact taaataagat aacagtgcct 62280
tgctcacaga aaacagcctg taatgtgaat tgacaattat tgctgctgat attgttttca
62340 gaaagttctt atatggagct gaaatctgca ttctgtaact tcgaaaactt
ggtcttaatt 62400 tggctcattg gcataacaga aaataagtct aatcatgccc
gcctgaggat ggttctactt 62460 atcacaagtc tcctcttagt ctagttcttc
atactcagtt ccttcagccc ttccacatgg 62520 gacgtaattt ccagatctct
caccatcctg actgcccttc cctggacagg ttctgtttga 62580 ccttcatccc
tccttggagg agtggccagg tgctggcaac taagacatgc gagctgtcca 62640
ccatctggat tatgcagatg aactaacatt gaaaatgaca cgctacatgc attacttaat
62700 ttcgttctca cagcaccttc atgaggagaa aactgaggct cagagatgtt
aagtagcttt 62760 ccccaaatcg tttagctcag aaattgtgga accagaattc
aacccagatc tgtctgactc 62820 caaagtctgc tcttctttct tggggaagtg
gaagcctgag tgctgttctt ggaacagcct 62880 caagacaata atctggggac
tgtcttggtc ctgcttgcag agggtccttc tgttacgtat 62940 gggtcctttc
tggcccttta gcttctacaa agaaagtcag tccccctcca gctctaaaga 63000
cacatgaagt ctgtttgcag tccagacctt gcaaacttgt agttatagaa acctcagagg
63060 cctaccaggg cttgaaggat atttggctcc actttacatc tccattcttc
ttttcctcct 63120 gtttttaatg taacctgtaa tcctagcaat ttgggaggct
gaggcaggtg gatcacctga 63180 ggtcaggagt tcaagatcag cctggccaac
atggtgaaac tccgtctcta ctaaaaatat 63240 aaaaattagc tgggctaatt
tttaattagt gtggtggccc gcgcctttat tcccagctac 63300 tcaggaggct
gaggcaggag aattgcttga acctggaagg cggagattgc agtgagctga 63360
gattgtgcca ttgcactcca gccttggcaa caagagtgaa actccgtctc aaaaaaaaaa
63420 agtattctgt ccaccacgtg gaataatgta atatttagta ataagaacag
ctgcaaggtg 63480 tagagagtta ccgtatatcc atcacccagc tttccttaac
gttaacattt tatataacca 63540 cagcatcatt ttgtcaaaac tagataatca
gcattggtac aatactgtta actaaactct 63600 aaacttcatt taggtttcat
caggctttcc actattgcct ttttcaattc caggatgcan 63660 nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 63720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt ttataagatt ttaaaactgg
63780 caaaaaatat tatggattta ttcatagcta gtaccagcat taaaattttt
tttttttttt 63840 ttttttttaa gaaacagggc ctcactctgt tgctgagtac
aatgctggag tacagtggcg 63900 tgattatagc tcattgtaac ctcaaactcc
tgggctcaag ggagcctcat tgcctcagcc 63960 tcctaagtag ctggaactac
aggtacatgc caccaaagcc cagctaatat tctgttattt 64020
ggtaaagatg gggtctcact gtgttgccca ggctggtctc gaactctttc tgccttggct
64080 tcaaccacag tgctgacatt acaagcatga gctactgagc ctggccaaga
ggaattaatt 64140 taactagaaa tctatagctt ttcaagctac caattaagtt
tgaaagtaga ataaaaacat 64200 tttctgattt gccaagattc aaaagacctc
ccaggaacct acaaggaagc tacaagatgt 64260 actccttcca catgagggaa
caagccaaga aaaaggaaga aattcaagaa acaggggatc 64320 caacacaggg
cagtggtata gagaatcaca gccatgcagc aggctgggac aagagtcaaa 64380
acagctcccg gatcaaccag gagaagaaag catagaactg acggttcact tgatgcgtct
64440 aaccttattc tgtggaatgt tacaatactg taggagaatt tggaagcaat
gaataatagt 64500 tatatggaga ataaagtaaa taatttcgta tagactacaa
actttgggaa aaacaagtta 64560 ttcaagaaag gtcatgtaat catagtatac
gactaaattc aacagtaatc aacatttata 64620 taatcactat gatataaata
ctaaatattt aaccaaaaat tgtgagttaa ctctactgag 64680 aagattccag
aagcagcagc aggattggtg gtctacgagt gctaaacctt catcttccat 64740
aataggtagt gctcaataga aaatatgtaa agttagtaaa tcaaaaaaca gtaaaaattt
64800 attagttata aataaggaag tagggccagg tgtggtatta tcccaacatt
ttgggaggcc 64860 gaggcaggtg gatcacttaa ggccagaagt tcgagactaa
cctggtcaac atagtgaaaa 64920 cccgtctcta ctaaaaatac aaaaattagc
taggcatgtt ggagcatgcc cataatccca 64980 gctcctcagg aggctaaggc
acgagaatca cctgaacctg ggaagtggag attgcagtga 65040 gccgagattg
tgccactgca atccagcctg ggcgacagag tgaaactctg tctcaaatta 65100
aataaataag gaggtaaata gcaaaaagca acagcttata gatttttaaa tggtggccag
65160 gcgcggtcgc tcacacctgt aattccagca ccctgagagg ccaggcggat
gggtcacctg 65220 agacaggagt tgagaccagc ctgaccaann nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn 65280 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 65340 nnnnnnnngc ggttcacgcc
tgatatccca gcattttggg aggccaaggc aggcgaatca 65400 tgaggttaag
agatcaagac catcctggcc aacatggtga aacctgtctc ccgttaaaat 65460
accaaaatta gcccggcatg gtggcaggta taatcccagc ttacttggga gactgaggca
65520 ggagaatcac ttggacccac ggaggcggag gttgcactga gctgagattg
cacccttgca 65580 atgcagcctg ggcaaccatt gccaaactcc atttccaaaa
aaaaaaaata ttcttagggt 65640 ttggggcttt tttggggggg gttggggtgt
aactatggta aatgggatta ccttttaaat 65700 tttttttctt ttttttgaga
tgggagtctt gctatgttgc ccaagctggt ctgaactact 65760 gggctcaagc
aatctgcctg cctcagcctc ccgagtagct gggattacag acgtacacca 65820
ttgtgccatc ttgatttctt ttcttgtttg tgtctagaaa tgctacttgt ttttgaatac
65880 tgattttgta tcctgcaact ttactaaatt cacttattag ttctgagact
tattgagtag 65940 agtctttata tttttctcgt tttttgagac agagtcttgc
tctgttgccc aggctggagt 66000 gtggtggtgt gatctcggct ctctgcaacc
cccacctccc aggttcaagt gattttccta 66060 cctcagcctc ctgagtaact
gggattacag gcatgcacca ccacgcccag ctaatttttt 66120 tgtattttta
gtagagacag ggtttcgcga tgttgaccag tctagtctca aactcctgac 66180
ctcaagtgat ccaccatcct ctaccaccca aagtgctggg attacaggca tgagccactg
66240 cgtccggcct gatttttcta tatataaaat catgtcatct gtaaacaggg
actattttac 66300 ttccttcttt tcaaattgaa tgtccttttt tctttctttt
gcctaattgc tctggctagg 66360 acttccagta ttatgttgta attcaagaaa
tatttgttga gaacttatca taaacaaaaa 66420 aattattcta ggcactagag
gaaaataata cagacaagaa ctatgtcttc tgccaggcac 66480 agttgctcat
gcctgtaatc ccagcacttt ggaaggtcga ggtgggcgga tcacctgagc 66540
tcaggagttc gagaccagcc tggccaaaat ggcgaaaccc cctctctact aaaaatacaa
66600 aaattagccg tggtggcatg cgccggtaat cccagctact ggggaacctg
aggcaggaga 66660 atcatcgaaa cccgggagtc ggaggttgca gtgggcacaa
gatcacgcca ctatactcca 66720 gcctgggcga nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 66780 nnnnnnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn cttttttttg 66840 ggggtttccc
cggccccccc cttttttttt tttttttttt tttttttttt tgtgagaccg 66900
agtcttgctc tgttgcccag gatggagtac aatggtgcaa tctctgctca ctgcaacctc
66960 cgcctcctgg gctcgagcag ttctcctgct ttagcttcct gagtagctgg
gattacaggt 67020 acccaccacc atgcttggct aatttttagt agagatgggg
tttcaccatg ctggccaggc 67080 tggtttcaaa ctcctgaccg taaatgatct
gcctgccttg gcctcccaaa gtgctgggat 67140 tacaggcatg agtcaccatg
tctggcctcc ccatttaaaa tggcaacccc tgccctgcct 67200 cctagcacct
ctgtctcctt cctctgcttt attttctcta gaacacttac caccacctga 67260
catattatat atcttaacta tttctttgtt tacagtctgc cttccctgct aagatgaaag
67320 gcattcttgt ctattttgat cattgctgta tttccagtgc cagtacttaa
taaatacttg 67380 ttgaataaat gcatgataaa ttctgaagct atttaaactt
tttcaattgt actgagcacg 67440 ggctcagtac aaggaaatct acacacatag
tttaccacat ttacacatca aaggtggatc 67500 aaaaattttt tcaataggca
tttgaaaaac attagaaatg aaatacttta ataacaaggg 67560 tgattatata
cttaatatac aaatgtctct acttttttaa ctcagtggta agaatttact 67620
ttttcaatct cataaagaag ggctctctaa gcaagatata aacacagaaa ataaaaggga
67680 aacataataa acttggctat acacattttt ttttttgaaa cagtcttgtt
ctgtcaccca 67740 ggctagagtg cagtggtgca acctcagctc actgcaacct
ccacctccca ggttcaagca 67800 attctcatgc ctcagtctga gtcatgtgcc
acccgcccca acccacccca ccccaccccc 67860 agctaattgt tctattttta
gtagagacag ggtttcacca tgttggccaa atttgttttt 67920 aactctgatg
aaaatgagtt aaacaaagtc aaagataatt taaactaagt cacaaaatat 67980
tgcaacatat aagannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
68040 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnaccaca 68100 gaatcagcaa cagttcacat agggcaaatg ttttaaataa
acatttttta aactccatgt 68160 tgcaagaagt agcaacacta acaaaagcaa
tatttatata aggacatact ttgtaaccag 68220 tttaaaggcc aagggagggt
taggttaatg agggctcagg cagtcaggaa ggcttctgag 68280 aggctatggc
cttgagaggc aggtggcctt ttggatagac agaaggaagc aggtggcaga 68340
ggtctggcag aggctgcatg aggccgaatc atggaagcct caaagtgaga cacaggttag
68400 agtccctgca gtagtgatgg ggaattctga aggcttttga gtcggggcat
ggcatgaaaa 68460 tttcacccct gcctcctcac ccatctgcct tgaatctaga
aagcacagct ggattccccc 68520 taaagttctg cctacatcag tggtttcttt
tccctcctag actgacattt tgtacagaag 68580 accctgagaa caccagcata
tccccaggcc gggagctctg gtttcgcaag tgtcgggatg 68640 gctggaggat
gaaaaacgaa accaggtaac caggactttc tcacacgttc cacccaggac 68700
acgttgacat gatgatctcc tagcatgtgc tggggatgga tctgggtgcc agggacatag
68760 catgaacaaa acagataaaa atctcttcct ttaagaagtt gggccgggcg
tggtggctca 68820 agcctgtaat cccagcactt tgggaggcca aggcaggcag
atcacctgag gtcaggagtt 68880 tgagaccagc ctggctaaca tagtgaaacc
ccatctctac taaaaaaaaa aaaaaaaaga 68940 atgccgggca tggtggtgtg
tgcctgtaat cccagctact tgggaggttg aggcaggaaa 69000 atcacttgaa
cctgaaaggt ggaggctgca gtgagctgaa accgcaatgt tgcactccag 69060
cctaggtgac agaaatgaag ctctgtctca aaaagaaaga aagggccagg catggaggct
69120 cacgcctgta atcccagcac tttgggaggc tgaggcaggc ggatcacgag
gtcaggagat 69180 cgacacaatc ctggctaaca cagtgaaacc tcatctctct
aaaaatataa aaaattagac 69240 gggcatggtg acgggtgcct gtagtcccag
ctactcggga ggctgaggca ggagaatggt 69300 atgaacctgg gaggaagagc
ttgcagtgag ctgagattgc accactgcac tccagcctgg 69360 ggtgacagag
tgagactccg tctcaaaaaa ataaaaaaaa aaaaaaaaaa nnnnnnnnnn 69420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
69480 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn aaaaaaaaaa aaaaaaaaaa
aaaagaagct 69540 gaccttctgc taggagataa agaagcaagt gaaatactgt
agataggatg ttggaagtgt 69600 taatgtctct tctgctcttt gtcctgcctc
aacctgtagg ggttcattgt acatgaccct 69660 actggcatga gatcttctct
gtaactaagt ccccaggttg gtgcccattc ctgccatctt 69720 tgaagtatct
tttttttttt cctttgagac atggtcttac tctgttaccc aggctggagc 69780
gcagtggcat gatcctggct cactgcagcc tcgacctccc caggcttggg tgatccttcc
69840 gcctttgcct cctgtatagc tgggaccaca ggcacttgcc accacgctga
gctaatttgt 69900 gtattttttt gcagagacgg ggtttcacca tgttgcccag
tctggtcttg aactccatgg 69960 ctcaagtgat ccgcctgcct tggcctccca
gagtgctggg attacaggtg tgagccactg 70020 tgcctggccc ctgccatctt
tgattgacat cttctctgta ataactagag ctgtgggaac 70080 gtgcctaagg
gctcctagct tccttctggc caccaggtca ggtttgggaa tggggtggga 70140
gataaagaga agcacaaagc atgttctcct ttcttaggtt ttctagaatg caggtaagtg
70200 tgggcctaat tctcccacac actttttttt tttttttttt gagacaaagt
ctcactctat 70260 cgctcaggct ggagtgcagt ggagtgatct tggcttacta
aaacctccgc ctcccgggtc 70320 caagtgattc tccttcctca accttccgag
tagctgggat tacaagtgcc tgctaccacg 70380 cctggctaat ttttgtattt
ttagttgaga tgggttttcg ccatgttggc caagttacca 70440 tgttggccaa
gttggtctca aactcttgat ctcaagtgat ctgcccacct tggcctccaa 70500
aagtgctggc attacaggtt tgagccacgg tgcccaaccc caatccttcc cctttttggg
70560 aaacagaaat gcccatgtat gtggagctaa gtgagacaga ggggttgtca
tgcttcacta 70620 tccccttgtc ccatgctgca atccgttatt tcagacgtga
ggaaggccca tcttgtggtg 70680 tgaggcagtg ggctcatcct ggggaacagc
cacacgccct ctaagccaaa acacctgcta 70740 aggaggaagg agactgtctc
ctcacaccat gcctgtcgcc accctttgct ctaacaaggg 70800 tactagataa
taatactgct gtggtacacc tagcacttag cttgggccca gcctgcaccc 70860
agggacttac ataatgatgt ttgtcatcaa cccactaggc aggggttgtt agccctgtgt
70920 acagatgagg aaccgaggct cagggagatg aagtttctct cccaaggccc
ccagcaatgg 70980 cagagggagt tgaagcaggt cggtctaccc caaagcctgt
gttgttgagc accgaggctc 71040 caagtgctca gatgatcacc tcgcgtctgt
ctgggtatca attatcaggc agctgtgccc 71100 gtgctccggg gtcgcctgtg
attaaccatt tgccaccccc aaggctgcgc tgcatcccag 71160 ctgctctgtc
tcctggttag gagctcaaca caaccacaag caccatcatc acaggactcg 71220
tgccatctaa ttaagggact cagtctagcg taggctcgta tgattttcta ctactataac
71280 gattgtaaat ctttatgtat ttaaatgtgt acatttcaaa gtgtttccac
atatattaac 71340 ttcattgatc ctccagacaa ccatgtagat tggacacacc
caggaaagat gactaaggaa 71400 ggctattctt tttttattga gacagggtct
tgctctgtca cccaggctgg agtacagtgg 71460 catgatcaca gctcattgca
gcctcgacct ccctgggctc agatgatctt cctacctcag 71520 cctcctgagt
agcttggatt acaggaatgt gccactatgc ctggctaatt tttgtagaga 71580
tgaggtttca ccatgttgcc caggctggtc tctatctcct gagctcaagt gatctgcctg
71640 cctcggcctc ccagtgctgg gtttgcaggc atgagccact gtgcccagtc
aggatggcta 71700 ttcttatgat aaaggctaag atatttattc ttctttcccg
ctttggaatt catatacctg 71760 agaactctat gattcaccct ctcactacta
attttagaaa acaagctgtc cttttccatt 71820 ccctcaaaaa caataggagt
ccaagtaata aatgaacact aggaagtcat agcatcatat 71880 gtaacatgtt
tagcatcctc cctcctgaca tggatgctgt tcacatgttc actgataagg 71940
agcctgagat tcagagaggt tcagtggtgt gttcacatag ctgagactag aatccaggtc
72000 tcctaactct cagtcttgcc ccctttctgc caatacagtg tctctcttgt
atttctagat 72060 caaggcaaag aggacacttt gatagttctc cccacacttg
tgtgtccatg attgtgtgtg 72120 tgtgtgtgtg tgtgtgtgtg tgtgtgtatg
ttgtgggtgg ataatatgta aatgcaagaa 72180 ctgtgatgta ctcaactcag
ggtccagagg gtgctgcagt gtggtgtttc tcaaagtgta 72240 tctatggctt
gtcaggttag ggagagaagg cagcactcgg gaccttgtcc atttattctg 72300
aaaggaatac atgtaaaata gtcccatagg ggtgtcagaa agcttggcct taaggtcaaa
72360 agagcacacc ctgaatacag gtttgcgcgt ttgctggtgt gtgagctaac
aaatgccact 72420 ctcacacggt ttctttcagt cccactgtgg agcttccctg
agggtgcccg ggcaagtctt 72480 gccagcaagg cagcaagact tcctgctatc
caagcccatg gaggaaagtt actgctgagg 72540 acccacccaa tggaaggatt
cttctcagcc ttgaacctgg agcactggga acaactggtc 72600 tcctgtgatg
gctgggactc ctcgcgggag gggactgcgc tgctatagct cttgctgcct 72660
ctcttgaata gctctaactc caaacctctg tccacacctc cagagcacca agtccagatt
72720 tgtgtgtaag cagctgggtg cctggggcct ctcgtgcaca ctggattggt
ttctcagttg 72780 ctgggcgagc ctgtactctg cctgacgagg aacgctggct
ccgaagaggc cctgtgtaga 72840 aggctgtcag ctgctcagcc tgctttgagc
ctcagtgaga agtccttccg acaggagctg 72900 actcatgtca ggatggcagg
cctggtatct tgctcgggcc ctagctgttg gggttctcat 72960 gggttgcact
gaccatactg cttacgtctt agccattccg tcctgctccc cagctcactc 73020
tctgaagcac acatcattgg ctttcctatt tttctgttca ttttttaatt gagcaaatgt
73080 ctattgaaca cttaaaatta attagaatgt ggtaatggac atattactga
gcctctccat 73140 ttggaaccca gtggagttgg gatttctaga ccctctttct
gtttggatgg tgtatgtgta 73200 tatgcatggg gaaaggcacc tggggcctgg
gggaggctat aggatataag cattagggac 73260 cctgaggctt taagtggttt
ctatttcttc ttagttatta tgtgccacct tcttagttat 73320 tatgtgccac
ctcccctatg agtgacgtgt ttgatcacta gcagaatagc aagcagagta 73380
tcattcatgc tggggccaga atgatggccg gttgccagat ataactgctt tggagcaaat
73440 ctcttctgtt tagagagata gaagttatga catatgtaat acacatctgt
gtacacagaa 73500 accggcacct gccagacaga gctggttcta agatttaata
cagtgctttt tttcctcttt 73560 gaaatatttt actttaatac cagtgccttt
tcttgttgaa cttcttggaa aagccaccaa 73620 ttctagatct tgatttgaat
taatacacac aatatctgag acacttacac ttttcaaaag 73680 atttgtgtat
gcattgccta attagagtag ggggagaagg gcaactatta ttatccctat 73740
tttacaaaac tgaggcttag tgaggttcag ccacatgcct agacttatat actagttagt
73800 ggtgcagcca gggagaggac tcagatttcc tggaggcaaa gtctatctct
gaaactccat 73860 gaagactttt gcagccagtt cccaccaata tgccccagac
gtgagacaaa caaggacttt 73920 tttttttata tagagccatc cataaaatcc
taagcccttt tattaatgta taaccaggag 73980 aacatctgtg ccaacggttg
gactttttat ggctgagatt cgggaggaag tgtgacacca 74040 agcaggagag
gaagaatgat tttctttgta cttaggtttt ctaaggacat tgttttaatc 74100
tgtatcgtgc caaagttgta tcactgttaa acttctgaag acataaccag ttgagtctta
74160 tttcaagata tgttctcaag ccaattgtgt gcttctcttg tttctgtgat
tgctttctag 74220 ccaaagcgaa gcttgtacag gttgagtatc ccttatccaa
aatgcttgga accagaagtg 74280 tttcaaattt tagattattt tcagattttg
gaatgtttgc atatacataa tgagatattt 74340 tgggaatagg acccgagcct
aaacacaaaa ttcattgatg tgtcagttac accttatcca 74400 catagcctga
gggtaatttt atacgatatt ttaaatagtt gtgtacatga agcatggttt 74460
gtggtaactt atgtgagggg ttttcccatt ttttgtcttg ttggtgctca aaaagttttg
74520 gattttggag catttcggat tttggatttt tggattaggg ttgctcaacc
catattattg 74580 gctgtacatc ctggtcactt ctgacttctg tttttactaa
tggaagcttt gcaaattgaa 74640 ttctcagtga gttgtatatt tatacacctg
gcttgaagcc ttaattgtat ataatgatgc 74700 tttttaaaaa atgctatttg
gaagactatt tatttctcgt gtatataatg tatataaaaa 74760 aatatggtta
gtgtttacct aaggttaacc aatttcaaga ttaaaatttt taaatagtaa 74820
aataataaaa aattataaag ttcttaatgg tctgacaact caattttttt tttttttttt
74880 tttttttttg agacagagcc tctctctgtc acccaggctg gagtgcagtg
gcaatcttgg 74940 ctcactacaa cctctgcctc ctgggctcag gtggtcctcc
cacctcagcc ttctgagtag 75000 ctgggattac agagatgcgt caccatgtct ggc
75033 <210> SEQ ID NO 19 <400> SEQUENCE: 19 000
<210> SEQ ID NO 20 <211> LENGTH: 289 <212> TYPE:
DNA <213> ORGANISM: homo sapiens <220> FEATURE:
<400> SEQUENCE: 20 cccatattat tggctgtaca tcctggtcac
ttctgacttc tgtttttact aatggaagct 60 ttgcaaattg aattctcagt
gagttgtata tttatacacc tggcttgaag ccttaattgt 120 atataatgat
actttttaaa aaatgctatt tggaagacta tttatttctc gtgtatataa 180
tgtatataaa aaaatatggt tagtgtttac ctaaggttaa ccaatttcaa gattaaaatt
240 tttaaatagt aaaataataa aaaattataa aaaaaaaaaa aaaaaaaaa 289
<210> SEQ ID NO 21 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 21 tcaacggctt gccccagaac 20 <210> SEQ
ID NO 22 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
22 ggtggaaaat gaaaacttgg 20 <210> SEQ ID NO 23 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 23 cccctcccaa
gaaacagaag 20 <210> SEQ ID NO 24 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 24 ggagttgctc atcctgcccc 20
<210> SEQ ID NO 25 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 25 ctctggacca aaaggtacgg 20 <210> SEQ
ID NO 26 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
26 tgtggagctt atcttccagc 20 <210> SEQ ID NO 27 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 27 ctcacagatg
gtttgacctc 20 <210> SEQ ID NO 28 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 28 gacggagagg tagcatcctt 20
<210> SEQ ID NO 29 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 29 cagggctgac acgagtttgt 20
<210> SEQ ID NO 30 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 30 attgaccgca tccgtgtaaa 20 <210> SEQ
ID NO 31 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
31 tccttctcct gcagccagtc 20 <210> SEQ ID NO 32 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 32 cgtccttctc
ctgcagccag 20 <210> SEQ ID NO 33 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 33 gtggacattc ccgagagaaa 20
<210> SEQ ID NO 34 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 34 ctccgaggct gtagccgatc 20 <210> SEQ
ID NO 35 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
35 aaacatgggc ccggcaggat 20 <210> SEQ ID NO 36 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 36 cagcctggct
ggaagtcacc 20 <210> SEQ ID NO 37 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 37 tcctgattca ccagagagtc 20
<210> SEQ ID NO 38 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 38 gcttgtcctg attcaccaga 20 <210> SEQ
ID NO 39 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
39 aaaactcggc ttgtcctgat 20 <210> SEQ ID NO 40 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 40 gcactggaag
gcaaaactcg 20 <210> SEQ ID NO 41 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 41 gaagcgattg gagtcagtgc 20
<210> SEQ ID NO 42 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 42 tgaaaggcat gcctgcccgg 20 <210> SEQ
ID NO 43 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
43 ctgataatgg taaactctga 20 <210> SEQ ID NO 44 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 44 ttcttgtaac
tgaagacatg 20 <210> SEQ ID NO 45 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 45 gacgtaaaag gtgggctcaa 20
<210> SEQ ID NO 46 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 46 gctccactat ttccagtggc 20 <210> SEQ
ID NO 47 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
47 gaaggtgttg gtggcattct 20 <210> SEQ ID NO 48 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 48 aggtctccca
agtcctcctc 20 <210> SEQ ID NO 49 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 49 aggccccctc ccaggtgagc 20
<210> SEQ ID NO 50 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 50 gtagctgcga aactccttcc 20
<210> SEQ ID NO 51 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 51 gatattcagc tcccgtccgg 20 <210> SEQ
ID NO 52 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
52 aaatgtcagt ttccgctggg 20 <210> SEQ ID NO 53 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 53 tgttctcagg
gtcttctgta 20 <210> SEQ ID NO 54 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 54 cacagtggga ctggtttcgt 20
<210> SEQ ID NO 55 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 55 ggcaccctca gggaagctcc 20 <210> SEQ
ID NO 56 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
56 ttgctgcctt gctggcaaga 20 <210> SEQ ID NO 57 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 57 gtcctcagca
gtaactttcc 20 <210> SEQ ID NO 58 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 58 acagaggttt ggagttagag 20
<210> SEQ ID NO 59 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 59 ccaatccagt gtgcacgaga 20 <210> SEQ
ID NO 60 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
60 gggcctcttc ggagccagcg 20 <210> SEQ ID NO 61 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 61 caacccatga
gaaccccaac 20 <210> SEQ ID NO 62 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 62 aggacggaat ggctaagacg 20
<210> SEQ ID NO 63 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 63 caatagacat ttgctcaatt 20 <210> SEQ
ID NO 64 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
64 atcccaactc cactgggttc 20 <210> SEQ ID NO 65 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 65 aggtgccttt
ccccatgcat 20 <210> SEQ ID NO 66 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 66 tgcttatatc ctatagcctc 20
<210> SEQ ID NO 67 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 67 ccacttaaag cctcagggtc 20 <210> SEQ
ID NO 68 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
68 tagtgatcaa acacgtcact 20 <210> SEQ ID NO 69 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 69 acatatgtca
taacttctat 20 <210> SEQ ID NO 70 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 70 caacaagaaa aggcactggt 20
<210> SEQ ID NO 71 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 71
ttaattcaaa tcaagatcta 20 <210> SEQ ID NO 72 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 72 ctaattaggc
aatgcataca 20 <210> SEQ ID NO 73 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 73 ctcactaagc ctcagttttg 20
<210> SEQ ID NO 74 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 74 tggctgcacc actaactagt 20 <210> SEQ
ID NO 75 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
75 gactttgcct ccaggaaatc 20 <210> SEQ ID NO 76 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 76 ggctgcaaaa
gtcttcatgg 20 <210> SEQ ID NO 77 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 77 atggatggct ctatataaaa 20
<210> SEQ ID NO 78 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 78 taaaagggct taggatttta 20 <210> SEQ
ID NO 79 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
79 acagatgttc tcctggttat 20 <210> SEQ ID NO 80 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 80 ataaaaagtc
caaccgttgg 20 <210> SEQ ID NO 81 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 81 ctcccgaatc tcagccataa 20
<210> SEQ ID NO 82 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 82 ctctcctgct tggtgtcaca 20 <210> SEQ
ID NO 83 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
83 atcattcttc ctctcctgct 20 <210> SEQ ID NO 84 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 84 ggcacgatac
agattaaaac 20 <210> SEQ ID NO 85 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 85 gaagtttaac agtgatacaa 20
<210> SEQ ID NO 86 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 86 ttgaaataag actcaactgg 20 <210> SEQ
ID NO 87 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
87 ccaaaacttt ttgagcacca 20 <210> SEQ ID NO 88 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 88 agacctttta
ctttttgcaa 20 <210> SEQ ID NO 89 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 89 cctagcctgg gaacccaaac 20
<210> SEQ ID NO 90 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 90 ggatccaaac ctgcagcaga 20 <210> SEQ
ID NO 91 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
91 tgaaggttac ctctgaaagg 20 <210> SEQ ID NO 92 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 92
taatggtaaa ctgcagtgac 20 <210> SEQ ID NO 93 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 93 aggcacttac
ttccgctggg 20 <210> SEQ ID NO 94 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 94 gtcatagatg acgaatgtaa 20
<210> SEQ ID NO 95 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 95 gaattctgcc agcagactgc 20 <210> SEQ
ID NO 96 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
96 ttcttaagaa gattgggttt 20 <210> SEQ ID NO 97 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 97 atatacaatt
aaggcttcaa 20 <210> SEQ ID NO 98 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 98 agtatcatta tatacaatta 20
<210> SEQ ID NO 99 <211> LENGTH: 2227 <212> TYPE:
DNA <213> ORGANISM: Mus musculus <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (275)...(1777)
<400> SEQUENCE: 99 cggcccgact tcgcagcggc tctgggaaag
gacaggtcgg gctgggcagc gtgtccctcc 60 acacgctcgc tttcccggtc
accgctcgca gcgctaccaa ccttccaggt tctgccagct 120 gtccacccca
tcaccttctg gccgacaccc ggcctgtcca cttctagtct ctggaggttt 180
tagtggtttc aaaccaaacc aacccaaacc aacccaacaa caaaaaagcc caaaccaaaa
240 acctgcttga gaggaggggg cgtggcgggg aagg atg cga aac acg gtt ttc
ctg 295 Met Arg Asn Thr Val Phe Leu 1 5 ctc ggc ttt tgg agc gtc tat
tgt tac ttc ccg gcg gga agt atc aca 343 Leu Gly Phe Trp Ser Val Tyr
Cys Tyr Phe Pro Ala Gly Ser Ile Thr 10 15 20 acc ttg cgt ccc cag
ggg tcg ctg cga gat gag cat cat aaa ccc act 391 Thr Leu Arg Pro Gln
Gly Ser Leu Arg Asp Glu His His Lys Pro Thr 25 30 35 gga gta cca
gct acc gcc aga ccc tct gtg gct ttt aac atc cgc act 439 Gly Val Pro
Ala Thr Ala Arg Pro Ser Val Ala Phe Asn Ile Arg Thr 40 45 50 55 tct
aag gac cca gag cag gaa ggg tgt aat ctc tcc ctt ggt gac agc 487 Ser
Lys Asp Pro Glu Gln Glu Gly Cys Asn Leu Ser Leu Gly Asp Ser 60 65
70 aaa ctc tta gaa aac tgt ggc ttc aac atg aca gcc aaa acc ttc ttc
535 Lys Leu Leu Glu Asn Cys Gly Phe Asn Met Thr Ala Lys Thr Phe Phe
75 80 85 atc att cat gga tgg acg atg agt ggc atg ttt gag agc tgg
ctg cat 583 Ile Ile His Gly Trp Thr Met Ser Gly Met Phe Glu Ser Trp
Leu His 90 95 100 aaa ctt gta tca gcc ctg cag atg aga gag aaa gat
gct aac gtc gtg 631 Lys Leu Val Ser Ala Leu Gln Met Arg Glu Lys Asp
Ala Asn Val Val 105 110 115 gtg gtt gac tgg ctg ccc ctg gct cat cag
ctg tac acg gat gca gtc 679 Val Val Asp Trp Leu Pro Leu Ala His Gln
Leu Tyr Thr Asp Ala Val 120 125 130 135 aat aac acc agg gtg gtg gga
cag aga gta gct ggg atg ctt gac tgg 727 Asn Asn Thr Arg Val Val Gly
Gln Arg Val Ala Gly Met Leu Asp Trp 140 145 150 ctg cag gag aag gaa
gag ttc tct ctt ggg aac gtt cac ttg att ggc 775 Leu Gln Glu Lys Glu
Glu Phe Ser Leu Gly Asn Val His Leu Ile Gly 155 160 165 tac agc ctt
gga gca cac gtg gct gga tac gct ggc aac ttt gtg aaa 823 Tyr Ser Leu
Gly Ala His Val Ala Gly Tyr Ala Gly Asn Phe Val Lys 170 175 180 gga
aca gtg ggc agg atc act ggt ctg gat ccc gcg ggt ccc atg ttt 871 Gly
Thr Val Gly Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Met Phe 185 190
195 gaa ggg gtg gac atc aac aga agg ctg tcc ccg gac gat gca gac ttt
919 Glu Gly Val Asp Ile Asn Arg Arg Leu Ser Pro Asp Asp Ala Asp Phe
200 205 210 215 gtg gat gtc ctg cat acc tac acg ctg tcc ttt ggc ttg
agc att ggg 967 Val Asp Val Leu His Thr Tyr Thr Leu Ser Phe Gly Leu
Ser Ile Gly 220 225 230 att cgg atg cct gtg ggt cac att gac atc tat
ccc aat ggc ggt gac 1015 Ile Arg Met Pro Val Gly His Ile Asp Ile
Tyr Pro Asn Gly Gly Asp 235 240 245 ttc cag cca ggc tgt gga ttc aat
gat gtc atc gga tct ttt gca tat 1063 Phe Gln Pro Gly Cys Gly Phe
Asn Asp Val Ile Gly Ser Phe Ala Tyr 250 255 260 gga aca atc tca gag
atg gtg aaa tgc gag cac gag cga gcc gta cac 1111 Gly Thr Ile Ser
Glu Met Val Lys Cys Glu His Glu Arg Ala Val His 265 270 275 ctc ttt
gtc gac tct ctg gtg aat cag gac aag ccc agc ttt gcc ttc 1159 Leu
Phe Val Asp Ser Leu Val Asn Gln Asp Lys Pro Ser Phe Ala Phe 280 285
290 295 cag tgc aca gac tcc agc cgc ttc aaa agg gga atc tgc ctc agc
tgc 1207 Gln Cys Thr Asp Ser Ser Arg Phe Lys Arg Gly Ile Cys Leu
Ser Cys 300 305 310 cgg aag aac cgt tgt aat aac att ggc tac aac gcc
aag aaa atg aga 1255 Arg Lys Asn Arg Cys Asn Asn Ile Gly Tyr Asn
Ala Lys Lys Met Arg 315 320 325 aag aag agg aat agc aaa atg tat tta
aaa acc cgg gct ggc atg cct 1303 Lys Lys Arg Asn Ser Lys Met Tyr
Leu Lys Thr Arg Ala Gly Met Pro 330 335 340 ttc aaa gtt tac cat tac
cag ctg aaa gtt cac atg ttc tct tac aat 1351 Phe Lys Val Tyr His
Tyr Gln Leu Lys Val His Met Phe Ser Tyr Asn 345 350 355 aac agt ggg
gac acc cag ccc acc ctc tac att acc ctg tat ggt agc 1399 Asn Ser
Gly Asp Thr Gln Pro Thr Leu Tyr Ile Thr Leu Tyr Gly Ser 360 365 370
375 aac gca gac tcc cag aac ctg ccc ttg gaa ata gtg gag aag att gag
1447 Asn Ala Asp Ser Gln Asn Leu Pro Leu Glu Ile Val Glu Lys Ile
Glu 380 385 390 ctg aat gcc aca aac acc ttc ctt gtc tac act gag gag
gac ttg ggc 1495 Leu Asn Ala Thr Asn Thr Phe Leu Val Tyr Thr Glu
Glu Asp Leu Gly 395 400 405 gat ctc ttg aag atg cga ctt acc tgg gag
ggg gta gcc cat tcc tgg 1543 Asp Leu Leu Lys Met Arg Leu Thr Trp
Glu Gly Val Ala His Ser Trp 410 415 420 tgc aac ctg tgg aat gag ttt
cgc aac tac ctg tct caa ccc agc aac 1591 Cys Asn Leu Trp Asn Glu
Phe Arg Asn Tyr Leu Ser Gln Pro Ser Asn 425 430 435 ccc tcg agg gag
ctg tac atc cgg cga att cgt gtc aaa tct ggg gaa 1639 Pro Ser Arg
Glu Leu Tyr Ile Arg Arg Ile Arg Val Lys Ser Gly Glu 440 445 450 455
acc cag cgc aaa gtg aca ttt tgc act caa gac cca acg aag agt agc
1687 Thr Gln Arg Lys Val Thr Phe Cys Thr Gln Asp Pro Thr Lys Ser
Ser 460 465 470 atc tcc cct ggc cag gag ctg tgg ttt cac aag tgt cag
gat ggc tgg 1735 Ile Ser Pro Gly Gln Glu Leu Trp Phe His Lys Cys
Gln Asp Gly Trp 475 480 485 aaa atg aaa aac aaa acc agt ccc ttt gtg
aac ttg gcc tga 1777 Lys Met Lys Asn Lys Thr Ser Pro Phe Val Asn
Leu Ala * 490 495 500 gggcccaaga agtcctggcg tccacaccca caccccactg
tccacgcaca tggaggaaaa 1837 gttactgctg aagacccact cgatggacga
tctcagcctt gagccccacg aggagcttgc 1897 ttgctgggct catcctgtct
cccctgacaa ctgtgacttc tcctggagag gcctgtgcac 1957 tgctgaagtt
cttgctgatg attctagctg taaacctttg ttgccgccgc aggaagctga 2017
ggccagcttg tgtgtgagca ctggagtgtc cagagccctg cacactcggg gtggggggcg
2077 gggtactctc cctgtcgcta ggtgagcact ggctttgtcc aacatcaggg
aacacaaggc 2137 tctgaagtgg ccctgtgtgg aaggttggca gctgcctggc
ctcactgaac cttagtgaca 2197 agtctttgcc tcaggagctg actcatgccg 2227
<210> SEQ ID NO 100 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 100 ttcccagagc cgctgcgaag 20
<210> SEQ ID NO 101 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 101 gaacctggaa ggttggtagc 20 <210> SEQ
ID NO 102 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
102 cctccagaga ctagaagtgg 20 <210> SEQ ID NO 103 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 103 actaaaacct
ccagagacta 20 <210> SEQ ID NO 104 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 104 cgtgtttcgc atccttcccc 20
<210> SEQ ID NO 105 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 105 aggttgtgat acttcccgcc 20 <210> SEQ
ID NO 106 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
106 tcatctcgca gcgacccctg 20 <210> SEQ ID NO 107 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 107 tggtactcca
gtgggtttat 20 <210> SEQ ID NO 108 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 108 tgcggatgtt aaaagccaca 20
<210> SEQ ID NO 109 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 109 gtcaccaagg gagagattac 20 <210> SEQ
ID NO 110 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
110 gccacagttt tctaagagtt 20 <210> SEQ ID NO 111 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 111 gttattgact
gcatccgtgt 20 <210> SEQ ID NO 112 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 112 accctggtgt tattgactgc 20
<210> SEQ ID NO 113 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 113 ccagtcaagc atcccagcta 20 <210> SEQ
ID NO 114 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
114 gttcccaaga gagaactctt 20 <210> SEQ ID NO 115 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 115 cacgtgtgct
ccaaggctgt 20 <210> SEQ ID NO 116 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 116 catccacaaa gtctgcatcg 20
<210> SEQ ID NO 117 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 117 caggacatcc acaaagtctg 20 <210> SEQ
ID NO 118 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
118 gtatgcagga catccacaaa 20 <210> SEQ ID NO 119 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 119 tgtaggtatg
caggacatcc 20 <210> SEQ ID NO 120 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 120 cagcgtgtag gtatgcagga 20
<210> SEQ ID NO 121 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 121 aaggacagcg tgtaggtatg 20
<210> SEQ ID NO 122 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 122 agccaaagga cagcgtgtag 20 <210> SEQ
ID NO 123 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
123 gctcaagcca aaggacagcg 20 <210> SEQ ID NO 124 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 124 ccaatgctca
agccaaagga 20 <210> SEQ ID NO 125 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 125 gaatcccaat gctcaagcca 20
<210> SEQ ID NO 126 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 126 catccgaatc ccaatgctca 20 <210> SEQ
ID NO 127 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
127 tagatgtcaa tgtgacccac 20 <210> SEQ ID NO 128 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 128 tgggatagat
gtcaatgtga 20 <210> SEQ ID NO 129 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 129 cgccattggg atagatgtca 20
<210> SEQ ID NO 130 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 130 tttcaccatc tctgagattg 20 <210> SEQ
ID NO 131 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
131 aaagaggtgt acggctcgct 20 <210> SEQ ID NO 132 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 132 tcgacaaaga
ggtgtacggc 20 <210> SEQ ID NO 133 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 133 gagagtcgac aaagaggtgt 20
<210> SEQ ID NO 134 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 134 caccagagag tcgacaaaga 20 <210> SEQ
ID NO 135 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
135 cagattcccc ttttgaagcg 20 <210> SEQ ID NO 136 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 136 ccaatgttat
tacaacggtt 20 <210> SEQ ID NO 137 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 137 tgtgaacttt cagctggtaa 20
<210> SEQ ID NO 138 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 138 taagagaaca tgtgaacttt 20 <210> SEQ
ID NO 139 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
139 cccactgtta ttgtaagaga 20 <210> SEQ ID NO 140 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 140 atttccaagg
gcaggttctg 20 <210> SEQ ID NO 141 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 141 gtgtagacaa ggaaggtgtt 20
<210> SEQ ID NO 142 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 142 gagatcgccc aagtcctcct 20
<210> SEQ ID NO 143 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 143 gtaagtcgca tcttcaagag 20 <210> SEQ
ID NO 144 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
144 taccccctcc caggtaagtc 20 <210> SEQ ID NO 145 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 145 ggaatgggct
accccctccc 20 <210> SEQ ID NO 146 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 146 ctcattccac aggttgcacc 20
<210> SEQ ID NO 147 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 147 gggtttcccc agatttgaca 20 <210> SEQ
ID NO 148 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
148 cacttgtgaa accacagctc 20 <210> SEQ ID NO 149 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 149 aaagggactg
gttttgtttt 20 <210> SEQ ID NO 150 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 150 ttgggccctc aggccaagtt 20
<210> SEQ ID NO 151 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 151 ccagcaagca agctcctcgt 20 <210> SEQ
ID NO 152 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
152 tcagcaagaa cttcagcagt 20 <210> SEQ ID NO 153 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 153 caaaggttta
cagctagaat 20 <210> SEQ ID NO 154 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 154 cttcctgcgg cggcaacaaa 20
<210> SEQ ID NO 155 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 155 gctcacacac aagctggcct 20 <210> SEQ
ID NO 156 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
156 gggctctgga cactccagtg 20 <210> SEQ ID NO 157 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 157 gctcacctag
cgacagggag 20 <210> SEQ ID NO 158 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 158 gccttgtgtt ccctgatgtt 20
<210> SEQ ID NO 159 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 159 acacagggcc acttcagagc 20 <210> SEQ
ID NO 160 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
160 cttccacaca gggccacttc 20 <210> SEQ ID NO 161 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 161 ttcagtgagg
ccaggcagct 20 <210> SEQ ID NO 162 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 162 taaggttcag tgaggccagg 20
<210> SEQ ID NO 163 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 163
gacttgtcac taaggttcag 20 <210> SEQ ID NO 164 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 164 aatagaacca
ggatccatca 20 <210> SEQ ID NO 165 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 165 tctgctagag atcaagggtg 20
<210> SEQ ID NO 166 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 166 gcgcagcagg tatgtagaac 20 <210> SEQ
ID NO 167 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
167 tcaaactact aaagggtgtc 20 <210> SEQ ID NO 168 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 168 ccaggaaacc
ttgctgggtc 20 <210> SEQ ID NO 169 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 169 atggagttac agaaaggatt 20
<210> SEQ ID NO 170 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<400> SEQUENCE: 170 acagatgcaa agaatgtgcg 20 <210> SEQ
ID NO 171 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Antisense Oligonucleotide <400> SEQUENCE:
171 tataaagctg gtacaataca 20 <210> SEQ ID NO 172 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Antisense Oligonucleotide <400> SEQUENCE: 172 aaaactaacc
atagatttgt 20 <210> SEQ ID NO 173 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 173 aaatcttgaa atcggttaat 20
<210> SEQ ID NO 174 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 174 gttctggggc aagccgttga 20 <210> SEQ
ID NO 175 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 175
gctggaagat aagctccaca 20 <210> SEQ ID NO 176 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 176 gaggtcaaac
catctgtgag 20 <210> SEQ ID NO 177 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 177 aaggatgcta cctctccgtc 20
<210> SEQ ID NO 178 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 178 acaaactcgt gtcagccctg 20 <210> SEQ
ID NO 179 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 179
tttacacgga tgcggtcaat 20 <210> SEQ ID NO 180 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 180 gactggctgc
aggagaagga 20 <210> SEQ ID NO 181 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 181 ctggctgcag gagaaggacg 20
<210> SEQ ID NO 182 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 182 tttctctcgg gaatgtccac 20 <210> SEQ
ID NO 183 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 183
gatcggctac agcctcggag 20 <210> SEQ ID NO 184 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 184 atcctgccgg
gcccatgttt 20 <210> SEQ ID NO 185 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 185
ggtgacttcc agccaggctg 20 <210> SEQ ID NO 186 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 186 gactctctgg
tgaatcagga 20 <210> SEQ ID NO 187 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 187 tctggtgaat caggacaagc 20
<210> SEQ ID NO 188 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 188 atcaggacaa gccgagtttt 20 <210> SEQ
ID NO 189 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 189
cgagttttgc cttccagtgc 20 <210> SEQ ID NO 190 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 190 gcactgactc
caatcgcttc 20 <210> SEQ ID NO 191 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 191 ccgggcaggc atgcctttca 20
<210> SEQ ID NO 192 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 192 tcagagttta ccattatcag 20 <210> SEQ
ID NO 193 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 193
catgtcttca gttacaagaa 20 <210> SEQ ID NO 194 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 194 ttgagcccac
cttttacgtc 20 <210> SEQ ID NO 195 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 195 gccactggaa atagtggagc 20
<210> SEQ ID NO 196 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 196 agaatgccac caacaccttc 20 <210> SEQ
ID NO 197 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 197
gaggaggact tgggagacct 20 <210> SEQ ID NO 198 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 198 ccggacggga
gctgaatatc 20 <210> SEQ ID NO 199 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 199 cccagcggaa actgacattt 20
<210> SEQ ID NO 200 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 200 tacagaagac cctgagaaca 20 <210> SEQ
ID NO 201 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 201
acgaaaccag tcccactgtg 20 <210> SEQ ID NO 202 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 202 ggagcttccc
tgagggtgcc 20 <210> SEQ ID NO 203 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 203 tcttgccagc aaggcagcaa 20
<210> SEQ ID NO 204 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 204 ggaaagttac tgctgaggac 20 <210> SEQ
ID NO 205 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 205
ctctaactcc aaacctctgt 20 <210> SEQ ID NO 206 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 206 tctcgtgcac
actggattgg 20 <210> SEQ ID NO 207 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 207 cgctggctcc gaagaggccc 20
<210> SEQ ID NO 208 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 208 cgtcttagcc attccgtcct 20 <210> SEQ
ID NO 209 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 209
aattgagcaa atgtctattg 20 <210> SEQ ID NO 210 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 210 atgcatgggg
aaaggcacct 20 <210> SEQ ID NO 211 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 211 gaggctatag gatataagca 20
<210> SEQ ID NO 212 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 212 gaccctgagg ctttaagtgg 20 <210> SEQ
ID NO 213 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 213
agtgacgtgt ttgatcacta 20 <210> SEQ ID NO 214 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 214 atagaagtta
tgacatatgt 20 <210> SEQ ID NO 215 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 215 accagtgcct tttcttgttg 20
<210> SEQ ID NO 216 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 216 tgtatgcatt gcctaattag 20 <210> SEQ
ID NO 217 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 217
caaaactgag gcttagtgag 20 <210> SEQ ID NO 218 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 218 actagttagt
ggtgcagcca 20 <210> SEQ ID NO 219 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 219 ccatgaagac ttttgcagcc 20
<210> SEQ ID NO 220 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 220 taaaatccta agccctttta 20 <210> SEQ
ID NO 221 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 221
ataaccagga gaacatctgt 20 <210> SEQ ID NO 222 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 222 ccaacggttg
gactttttat 20 <210> SEQ ID NO 223 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 223 ttatggctga gattcgggag 20
<210> SEQ ID NO 224 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 224 tgtgacacca agcaggagag 20 <210> SEQ
ID NO 225 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 225
agcaggagag gaagaatgat 20 <210> SEQ ID NO 226 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 226 gttttaatct
gtatcgtgcc 20 <210> SEQ ID NO 227 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: H. sapiens <220>
FEATURE: <400> SEQUENCE: 227 ttgtatcact gttaaacttc 20
<210> SEQ ID NO 228 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: H. sapiens <220> FEATURE:
<400> SEQUENCE: 228 ccagttgagt cttatttcaa 20 <210> SEQ
ID NO 229 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: H. sapiens <220> FEATURE: <400> SEQUENCE: 229
tggtgctcaa aaagttttgg 20 <210> SEQ ID NO 230 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: H. sapiens
<220> FEATURE: <400> SEQUENCE: 230 gtcactgcag
tttaccatta 20 <210> SEQ ID NO 231 <211> LENGTH: 20
<212> TYPE: DNA
<213> ORGANISM: H. sapiens <220> FEATURE: <400>
SEQUENCE: 231 cccagcggaa gtaagtgcct 20 <210> SEQ ID NO 232
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
H. sapiens <220> FEATURE: <400> SEQUENCE: 232
ttacattcgt catctatgac 20 <210> SEQ ID NO 233 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 233 cttcgcagcg
gctctgggaa 20 <210> SEQ ID NO 234 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 234 gctaccaacc ttccaggttc 20
<210> SEQ ID NO 235 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 235 tagtctctgg aggttttagt 20 <210> SEQ
ID NO 236 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
236 ggggaaggat gcgaaacacg 20 <210> SEQ ID NO 237 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 237 ggcgggaagt
atcacaacct 20 <210> SEQ ID NO 238 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 238 ataaacccac tggagtacca 20
<210> SEQ ID NO 239 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 239 tgtggctttt aacatccgca 20 <210> SEQ
ID NO 240 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
240 gtaatctctc ccttggtgac 20 <210> SEQ ID NO 241 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 241 aactcttaga
aaactgtggc 20 <210> SEQ ID NO 242 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 242 acacggatgc agtcaataac 20
<210> SEQ ID NO 243 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 243 gcagtcaata acaccagggt 20 <210> SEQ
ID NO 244 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
244 tagctgggat gcttgactgg 20 <210> SEQ ID NO 245 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 245 acagccttgg
agcacacgtg 20 <210> SEQ ID NO 246 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 246 cgatgcagac tttgtggatg 20
<210> SEQ ID NO 247 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 247 tcctgcatac ctacacgctg 20 <210> SEQ
ID NO 248 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
248 ctacacgctg tcctttggct 20 <210> SEQ ID NO 249 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 249 cgctgtcctt
tggcttgagc 20 <210> SEQ ID NO 250 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 250 tcctttggct tgagcattgg 20
<210> SEQ ID NO 251 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 251 caatctcaga gatggtgaaa 20 <210> SEQ
ID NO 252 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
252 agcgagccgt acacctcttt 20 <210> SEQ ID NO 253 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 253 gccgtacacc
tctttgtcga 20 <210> SEQ ID NO 254
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
M. musculus <220> FEATURE: <400> SEQUENCE: 254
tctttgtcga ctctctggtg 20 <210> SEQ ID NO 255 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 255 cgcttcaaaa
ggggaatctg 20 <210> SEQ ID NO 256 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 256 aaccgttgta ataacattgg 20
<210> SEQ ID NO 257 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 257 ttaccagctg aaagttcaca 20 <210> SEQ
ID NO 258 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
258 aaagttcaca tgttctctta 20 <210> SEQ ID NO 259 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 259 tctcttacaa
taacagtggg 20 <210> SEQ ID NO 260 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 260 cagaacctgc ccttggaaat 20
<210> SEQ ID NO 261 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 261 aacaccttcc ttgtctacac 20 <210> SEQ
ID NO 262 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
262 aggaggactt gggcgatctc 20 <210> SEQ ID NO 263 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 263 ctcttgaaga
tgcgacttac 20 <210> SEQ ID NO 264 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 264 tgtcaaatct ggggaaaccc 20
<210> SEQ ID NO 265 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 265 gagctgtggt ttcacaagtg 20 <210> SEQ
ID NO 266 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
266 actgctgaag ttcttgctga 20 <210> SEQ ID NO 267 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 267 tttgttgccg
ccgcaggaag 20 <210> SEQ ID NO 268 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 268 ctccctgtcg ctaggtgagc 20
<210> SEQ ID NO 269 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 269 aacatcaggg aacacaaggc 20 <210> SEQ
ID NO 270 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
270 gctctgaagt ggccctgtgt 20 <210> SEQ ID NO 271 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 271 agctgcctgg
cctcactgaa 20 <210> SEQ ID NO 272 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 272 cctggcctca ctgaacctta 20
<210> SEQ ID NO 273 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 273 ctgaacctta gtgacaagtc 20 <210> SEQ
ID NO 274 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
274 cacccttgat ctctagcaga 20 <210> SEQ ID NO 275 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 275 gttctacata
cctgctgcgc 20 <210> SEQ ID NO 276 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: M. musculus <220>
FEATURE: <400> SEQUENCE: 276 gacacccttt agtagtttga 20
<210> SEQ ID NO 277 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: M. musculus <220> FEATURE:
<400> SEQUENCE: 277 gacccagcaa ggtttcctgg 20 <210> SEQ
ID NO 278 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: M. musculus <220> FEATURE: <400> SEQUENCE:
278 cgcacattct ttgcatctgt 20 <210> SEQ ID NO 279 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: M. musculus
<220> FEATURE: <400> SEQUENCE: 279 tgtattgtac
cagctttata 20 <210> SEQ ID NO 280 <211> LENGTH: 19
<212> TYPE: RNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Antisense
Oligonucleotide <400> SEQUENCE: 280 cgagaggcgg acgggaccg 19
<210> SEQ ID NO 281 <211> LENGTH: 21 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Antisense Oligonucleotide
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)...(19) <223> OTHER INFORMATION: bases at these
positions are RNA <400> SEQUENCE: 281 cgagaggcgg acgggaccgt t
21 <210> SEQ ID NO 282 <211> LENGTH: 21 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Antisense Oligonucleotide
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: 3, 4, 6, 8, 9, 10, 11, 12, 14, 15, 16, 17, 19, 20, 21
<223> OTHER INFORMATION: bases at these positions are RNA
<400> SEQUENCE: 282 ttgctctccg cctgccctgg c 21
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