U.S. patent application number 11/891963 was filed with the patent office on 2009-06-18 for modulating robo: ligand interactions. This patent application is currently assigned to The Regents of the University of California. Invention is credited to Katja Brose, Corey S. Goodman, Thomas Kidd, Marc Tessier-Lavigne.
Application Number | 20090155928 11/891963 |
Document ID | / |
Family ID | 26745709 |
Filed Date | 2009-06-18 |
United States Patent Application | 20090155928 |
Kind Code | A1 |
Goodman; Corey S. ; et al. | June 18, 2009 |
Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.
Inventors: | Goodman; Corey S.; (Berkeley, CA) ; Kidd; Thomas; (Berkeley, CA) ; Brose; Katja; (San Francisco, CA) ; Tessier-Lavigne; Marc; (San Francisco, CA) |
Correspondence Address: |
TOWNSEND AND TOWNSEND AND CREW, LLP TWO EMBARCADERO CENTER, EIGHTH FLOOR SAN FRANCISCO CA 94111-3834 US |
Assignee: | The Regents of the University of
California Oakland CA |
Family ID: | 26745709 |
Appl. No.: | 11/891963 |
Filed: | August 13, 2007 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
11022546 | Dec 23, 2004 | |||
11891963 | ||||
10289776 | Nov 6, 2002 | 6861228 | ||
11022546 | ||||
09922600 | Aug 3, 2001 | |||
10289776 | ||||
09540245 | Mar 31, 2000 | 6270984 | ||
09922600 | ||||
09191647 | Nov 13, 1998 | 6046015 | ||
09540245 | ||||
60081057 | Apr 7, 1998 | |||
60065544 | Nov 14, 1997 | |||
Current U.S. Class: | 436/501 ; 530/350; 536/23.5 |
Current CPC Class: | A61P 43/00 20180101; G01N 2500/02 20130101; G01N 2333/43573 20130101; A61K 38/00 20130101; C07K 14/4702 20130101; G01N 33/566 20130101; G01N 33/68 20130101; C07K 14/70503 20130101 |
Class at Publication: | 436/501 ; 530/350; 536/23.5 |
International Class: | G01N 33/566 20060101 G01N033/566; C07K 14/00 20060101 C07K014/00; C12N 15/11 20060101 C12N015/11 |
Sequence CWU 1
1
2014758DNAhumanCDS(1)..(4575) 1atg cgc ggc gtt ggc tgg cag atg ctg
tcc ctg tcg ctg ggg tta gtg 48Met Arg Gly Val Gly Trp Gln Met Leu
Ser Leu Ser Leu Gly Leu Val1 5 10 15ctg gcg atc ctg aac aag gtg gca
ccg cag gcg tgc ccg gcg cag tgc 96Leu Ala Ile Leu Asn Lys Val Ala
Pro Gln Ala Cys Pro Ala Gln Cys20 25 30tct tgc tcg ggc agc aca gtg
gac tgt cac ggg ctg gcg ctg cgc agc 144Ser Cys Ser Gly Ser Thr Val
Asp Cys His Gly Leu Ala Leu Arg Ser35 40 45gtg ccc agg aat atc ccc
cgc aac acc gag aga ctg gat tta aat gga 192Val Pro Arg Asn Ile Pro
Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly50 55 60aat aac atc aca aga
att acg aag aca gat ttt gct ggt ctt aga cat 240Asn Asn Ile Thr Arg
Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His65 70 75 80cta aga gtt
ctt cag ctt atg gag aat aag att agc acc att gaa aga 288Leu Arg Val
Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg85 90 95gga gca
ttc cag gat ctt aaa gaa cta gag aga ctg cgt tta aac aga 336Gly Ala
Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg100 105
110aat cac ctt cag ctg ttt cct gag ttg ctg ttt ctt ggg act gcg aag
384Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala
Lys115 120 125cta tac agg ctt gat ctc agt gaa aac caa att cag gca
atc cca agg 432Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala
Ile Pro Arg130 135 140aaa gct ttc cgt ggg gca gtt gac ata aaa aat
ttg caa ctg gat tac 480Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn
Leu Gln Leu Asp Tyr145 150 155 160aac cag atc agc tgt att gaa gat
ggg gca ttc agg gct ctc cgg gac 528Asn Gln Ile Ser Cys Ile Glu Asp
Gly Ala Phe Arg Ala Leu Arg Asp165 170 175ctg gaa gtg ctc act ctc
aac aat aac aac att act aga ctt tct gtg 576Leu Glu Val Leu Thr Leu
Asn Asn Asn Asn Ile Thr Arg Leu Ser Val180 185 190gca agt ttc aac
cat atg cct aaa ctt agg act ttt cga ctg cat tca 624Ala Ser Phe Asn
His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser195 200 205aac aac
ctg tat tgt gac tgc cac ctg gcc tgg ctc tcc gac tgg ctt 672Asn Asn
Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu210 215
220cgc aaa agg cct cgg gtt ggt ctg tac act cag tgt atg ggc ccc tcc
720Arg Lys Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro
Ser225 230 235 240cac ctg aga ggc cat aat gta gcc gag gtt caa aaa
cga gaa ttt gtc 768His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys
Arg Glu Phe Val245 250 255tgc agt gat gag gaa gaa ggt cac cag tca
ttt atg gct cct tct tgt 816Cys Ser Asp Glu Glu Glu Gly His Gln Ser
Phe Met Ala Pro Ser Cys260 265 270agt gtt ttg cac tgc cct gcc gcc
tgt acc tgt agc aac aat atc gta 864Ser Val Leu His Cys Pro Ala Ala
Cys Thr Cys Ser Asn Asn Ile Val275 280 285gac tgt cgt ggg aaa ggt
ctc act gag atc ccc aca aat ctt cca gag 912Asp Cys Arg Gly Lys Gly
Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu290 295 300acc atc aca gaa
ata cgt ttg gaa cag aac aca atc aaa gtc atc cct 960Thr Ile Thr Glu
Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro305 310 315 320cct
gga gct ttc tca cca tat aaa aag ctt aga cga att gac ctg agc 1008Pro
Gly Ala Phe Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser325 330
335aat aat cag atc tct gaa ctt gca cca gat gct ttc caa gga cta cgc
1056Asn Asn Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu
Arg340 345 350tct ctg aat tca ctt gtc ctc tat gga aat aaa atc aca
gaa ctc ccc 1104Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr
Glu Leu Pro355 360 365aaa agt tta ttt gaa gga ctg ttt tcc tta cag
ctc cta tta ttg aat 1152Lys Ser Leu Phe Glu Gly Leu Phe Ser Leu Gln
Leu Leu Leu Leu Asn370 375 380gcc aac aag ata aac tgc ctt cgg gta
gat gct ttt cag gat ctc cac 1200Ala Asn Lys Ile Asn Cys Leu Arg Val
Asp Ala Phe Gln Asp Leu His385 390 395 400aac ttg aac ctt ctc tcc
cta tat gac aac aag ctt cag acc atc gcc 1248Asn Leu Asn Leu Leu Ser
Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala405 410 415aag ggg acc ttt
tca cct ctt cgg gcc att caa act atg cat ttg gcc 1296Lys Gly Thr Phe
Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala420 425 430cag aac
ccc ttt att tgt gac tgc cat ctc aag tgg cta gcg gat tat 1344Gln Asn
Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr435 440
445ctc cat acc aac ccg att gag acc agt ggt gcc cgt tgc acc agc ccc
1392Leu His Thr Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser
Pro450 455 460cgc cgc ctg gca aac aaa aga att gga cag atc aaa agc
aag aaa ttc 1440Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser
Lys Lys Phe465 470 475 480cgt tgt tca ggt aca gaa gat tat cga tca
aaa tta agt gga gac tgc 1488Arg Cys Ser Gly Thr Glu Asp Tyr Arg Ser
Lys Leu Ser Gly Asp Cys485 490 495ttt gcg gat ctg gct tgc cct gaa
aag tgt cgc tgt gaa gga acc aca 1536Phe Ala Asp Leu Ala Cys Pro Glu
Lys Cys Arg Cys Glu Gly Thr Thr500 505 510gta gat tgc tct aat caa
aag ctc aac aaa atc ccg gag cac att ccc 1584Val Asp Cys Ser Asn Gln
Lys Leu Asn Lys Ile Pro Glu His Ile Pro515 520 525cag tac act gca
gag ttg cgt ctc aat aat aat gaa ttt acc gtg ttg 1632Gln Tyr Thr Ala
Glu Leu Arg Leu Asn Asn Asn Glu Phe Thr Val Leu530 535 540gaa gcc
aca gga atc ttt aag aaa ctt cct caa tta cgt aaa ata aac 1680Glu Ala
Thr Gly Ile Phe Lys Lys Leu Pro Gln Leu Arg Lys Ile Asn545 550 555
560ttt agc aac aat aag atc aca gat att gag gag gga gca ttt gaa gga
1728Phe Ser Asn Asn Lys Ile Thr Asp Ile Glu Glu Gly Ala Phe Glu
Gly565 570 575gca tct ggt gta aat gaa ata ctt ctt acg agt aat cgt
ttg gaa aat 1776Ala Ser Gly Val Asn Glu Ile Leu Leu Thr Ser Asn Arg
Leu Glu Asn580 585 590gtg cag cat aag atg ttc aag gga ttg gaa agc
ctc aaa act ttg atg 1824Val Gln His Lys Met Phe Lys Gly Leu Glu Ser
Leu Lys Thr Leu Met595 600 605ttg aga agc aat cga ata acc tgt gtg
ggg aat gac agt ttc ata gga 1872Leu Arg Ser Asn Arg Ile Thr Cys Val
Gly Asn Asp Ser Phe Ile Gly610 615 620ctc agt tct gtg cgt ttg ctt
tct ttg tat gat aat caa att act aca 1920Leu Ser Ser Val Arg Leu Leu
Ser Leu Tyr Asp Asn Gln Ile Thr Thr625 630 635 640gtt gca cca ggg
gca ttt gat act ctc cat tct tta tct act cta aac 1968Val Ala Pro Gly
Ala Phe Asp Thr Leu His Ser Leu Ser Thr Leu Asn645 650 655ctc ttg
gcc aat cct ttt aac tgt aac tgc tac ctg gct tgg ttg gga 2016Leu Leu
Ala Asn Pro Phe Asn Cys Asn Cys Tyr Leu Ala Trp Leu Gly660 665
670gag tgg ctg aga aag aag aga att gtc acg gga aat cct aga tgt caa
2064Glu Trp Leu Arg Lys Lys Arg Ile Val Thr Gly Asn Pro Arg Cys
Gln675 680 685aaa cca tac ttc ctg aaa gaa ata ccc atc cag gat gtg
gcc att cag 2112Lys Pro Tyr Phe Leu Lys Glu Ile Pro Ile Gln Asp Val
Ala Ile Gln690 695 700gac ttc act tgt gat gac gga aat gat gac aat
agt tgc tcc cca ctt 2160Asp Phe Thr Cys Asp Asp Gly Asn Asp Asp Asn
Ser Cys Ser Pro Leu705 710 715 720tct cgc tgt cct act gaa tgt act
tgc ttg gat aca gtc gtc cga tgt 2208Ser Arg Cys Pro Thr Glu Cys Thr
Cys Leu Asp Thr Val Val Arg Cys725 730 735agc aac aag ggt ttg aag
gtc ttg ccg aaa ggt att cca aga gat gtc 2256Ser Asn Lys Gly Leu Lys
Val Leu Pro Lys Gly Ile Pro Arg Asp Val740 745 750aca gag ttg tat
ctg gat gga aac caa ttt aca ctg gtt ccc aag gaa 2304Thr Glu Leu Tyr
Leu Asp Gly Asn Gln Phe Thr Leu Val Pro Lys Glu755 760 765ctc tcc
aac tac aaa cat tta aca ctt ata gac tta agt aac aac aga 2352Leu Ser
Asn Tyr Lys His Leu Thr Leu Ile Asp Leu Ser Asn Asn Arg770 775
780ata agc acg ctt tct aat cag agc ttc agc aac atg acc cag ctc ctc
2400Ile Ser Thr Leu Ser Asn Gln Ser Phe Ser Asn Met Thr Gln Leu
Leu785 790 795 800acc tta att ctt agt tac aac cgt ctg aga tgt att
cct cct cgc acc 2448Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile
Pro Pro Arg Thr805 810 815ttt gat gga tta aag tct ctt cga tta ctt
tct cta cat gga aat gac 2496Phe Asp Gly Leu Lys Ser Leu Arg Leu Leu
Ser Leu His Gly Asn Asp820 825 830att tct gtt gtg cct gaa ggt gct
ttc aat gat ctt tct gca tta tca 2544Ile Ser Val Val Pro Glu Gly Ala
Phe Asn Asp Leu Ser Ala Leu Ser835 840 845cat cta gca att gga gcc
aac cct ctt tac tgt gat tgt aac atg cag 2592His Leu Ala Ile Gly Ala
Asn Pro Leu Tyr Cys Asp Cys Asn Met Gln850 855 860tgg tta tcc gac
tgg gtg aag tcg gaa tat aag gag cct gga att gct 2640Trp Leu Ser Asp
Trp Val Lys Ser Glu Tyr Lys Glu Pro Gly Ile Ala865 870 875 880cgt
tgt gct ggt cct gga gaa atg gca gat aaa ctt tta ctc aca act 2688Arg
Cys Ala Gly Pro Gly Glu Met Ala Asp Lys Leu Leu Leu Thr Thr885 890
895ccc tcc aaa aaa ttt acc tgt caa ggt cct gtg gat gtc aat att cta
2736Pro Ser Lys Lys Phe Thr Cys Gln Gly Pro Val Asp Val Asn Ile
Leu900 905 910gct aag tgt aac ccc tgc cta tca aat ccg tgt aaa aat
gat ggc aca 2784Ala Lys Cys Asn Pro Cys Leu Ser Asn Pro Cys Lys Asn
Asp Gly Thr915 920 925tgt aat agt gat cca gtt gac ttt tac cga tgc
acc tgt cca tat ggt 2832Cys Asn Ser Asp Pro Val Asp Phe Tyr Arg Cys
Thr Cys Pro Tyr Gly930 935 940ttc aag ggg cag gac tgt gat gtc cca
att cat gcc tgc atc agt aac 2880Phe Lys Gly Gln Asp Cys Asp Val Pro
Ile His Ala Cys Ile Ser Asn945 950 955 960cca tgt aaa cat gga gga
act tgc cac tta aag gaa gga gaa gaa gat 2928Pro Cys Lys His Gly Gly
Thr Cys His Leu Lys Glu Gly Glu Glu Asp965 970 975gga ttc tgg tgt
att tgt gct gat gga ttt gaa gga gaa aat tgt gaa 2976Gly Phe Trp Cys
Ile Cys Ala Asp Gly Phe Glu Gly Glu Asn Cys Glu980 985 990gtc aac
gtt gat gat tgt gaa gat aat gac tgt gaa aat aat tct aca 3024Val Asn
Val Asp Asp Cys Glu Asp Asn Asp Cys Glu Asn Asn Ser Thr995 1000
1005tgt gtc gat ggc att aat aac tac aca tgc ctt tgc cca cct gag tat
3072Cys Val Asp Gly Ile Asn Asn Tyr Thr Cys Leu Cys Pro Pro Glu
Tyr1010 1015 1020aca ggt gag ttg tgt gag gag aag ctg gac ttc tgt
gcc cag gac ctg 3120Thr Gly Glu Leu Cys Glu Glu Lys Leu Asp Phe Cys
Ala Gln Asp Leu1025 1030 1035 1040aac ccc tgc cag cac gat tca aag
tgc atc cta act cca aag gga ttc 3168Asn Pro Cys Gln His Asp Ser Lys
Cys Ile Leu Thr Pro Lys Gly Phe1045 1050 1055aaa tgt gac tgc aca
cca ggg tac gta ggt gaa cac tgc gac atc gat 3216Lys Cys Asp Cys Thr
Pro Gly Tyr Val Gly Glu His Cys Asp Ile Asp1060 1065 1070ttt gac
gac tgc caa gac aac aag tgt aaa aac gga gcc cac tgc aca 3264Phe Asp
Asp Cys Gln Asp Asn Lys Cys Lys Asn Gly Ala His Cys Thr1075 1080
1085gat gca gtg aac ggc tat acg tgc ata tgc ccc gaa ggt tac agt ggc
3312Asp Ala Val Asn Gly Tyr Thr Cys Ile Cys Pro Glu Gly Tyr Ser
Gly1090 1095 1100ttg ttc tgt gag ttt tct cca ccc atg gtc ctc cct
cgt acc agc ccc 3360Leu Phe Cys Glu Phe Ser Pro Pro Met Val Leu Pro
Arg Thr Ser Pro1105 1110 1115 1120tgt gat aat ttt gat tgt cag aat
gga gct cag tgt atc gtc aga ata 3408Cys Asp Asn Phe Asp Cys Gln Asn
Gly Ala Gln Cys Ile Val Arg Ile1125 1130 1135aat gag cca ata tgt
cag tgt ttg cct ggc tat cag gga gaa aag tgt 3456Asn Glu Pro Ile Cys
Gln Cys Leu Pro Gly Tyr Gln Gly Glu Lys Cys1140 1145 1150gaa aaa
ttg gtt agt gtg aat ttt ata aac aaa gag tct tat ctt cag 3504Glu Lys
Leu Val Ser Val Asn Phe Ile Asn Lys Glu Ser Tyr Leu Gln1155 1160
1165att cct tca gcc aag gtt cgg cct cag acg aac ata aca ctt cag att
3552Ile Pro Ser Ala Lys Val Arg Pro Gln Thr Asn Ile Thr Leu Gln
Ile1170 1175 1180gcc aca gat gaa gac agc gga atc ctc ctg tat aag
ggt gac aaa gac 3600Ala Thr Asp Glu Asp Ser Gly Ile Leu Leu Tyr Lys
Gly Asp Lys Asp1185 1190 1195 1200cat atc gcg gta gaa ctc tat cgg
ggg cgt gtt cgt gcc agc tat gac 3648His Ile Ala Val Glu Leu Tyr Arg
Gly Arg Val Arg Ala Ser Tyr Asp1205 1210 1215acc ggc tct cat cca
gct tct gcc att tac agt gtg gag aca atc aat 3696Thr Gly Ser His Pro
Ala Ser Ala Ile Tyr Ser Val Glu Thr Ile Asn1220 1225 1230gat gga
aac ttc cac att gtg gaa cta ctt gcc ttg gat cag agt ctc 3744Asp Gly
Asn Phe His Ile Val Glu Leu Leu Ala Leu Asp Gln Ser Leu1235 1240
1245tct ttg tcc gtg gat ggt ggg aac ccc aaa atc atc act aac ttg tca
3792Ser Leu Ser Val Asp Gly Gly Asn Pro Lys Ile Ile Thr Asn Leu
Ser1250 1255 1260aag cag tcc act ctg aat ttt gac tct cca ctc tat
gta gga ggc atg 3840Lys Gln Ser Thr Leu Asn Phe Asp Ser Pro Leu Tyr
Val Gly Gly Met1265 1270 1275 1280cca ggg aag agt aac gtg gca tct
ctg cgc cag gcc cct ggg cag aac 3888Pro Gly Lys Ser Asn Val Ala Ser
Leu Arg Gln Ala Pro Gly Gln Asn1285 1290 1295gga acc agc ttc cac
ggc tgc atc cgg aac ctt tac atc aac agt gag 3936Gly Thr Ser Phe His
Gly Cys Ile Arg Asn Leu Tyr Ile Asn Ser Glu1300 1305 1310ctg cag
gac ttc cag aag gtg ccg atg caa aca ggc att ttg cct ggc 3984Leu Gln
Asp Phe Gln Lys Val Pro Met Gln Thr Gly Ile Leu Pro Gly1315 1320
1325tgt gag cca tgc cac aag aag gtg tgt gcc cat ggc aca tgc cag ccc
4032Cys Glu Pro Cys His Lys Lys Val Cys Ala His Gly Thr Cys Gln
Pro1330 1335 1340agc agc cag gca ggc ttc acc tgc gag tgc cag gaa
gga tgg atg ggg 4080Ser Ser Gln Ala Gly Phe Thr Cys Glu Cys Gln Glu
Gly Trp Met Gly1345 1350 1355 1360ccc ctc tgt gac caa cgg acc aat
gac cct tgc ctt gga aat aaa tgc 4128Pro Leu Cys Asp Gln Arg Thr Asn
Asp Pro Cys Leu Gly Asn Lys Cys1365 1370 1375gta cat ggc acc tgc
ttg ccc atc aat gcg ttc tcc tac agc tgt aag 4176Val His Gly Thr Cys
Leu Pro Ile Asn Ala Phe Ser Tyr Ser Cys Lys1380 1385 1390tgc ttg
gag ggc cat gga ggt gtc ctc tgt gat gaa gag gag gat ctg 4224Cys Leu
Glu Gly His Gly Gly Val Leu Cys Asp Glu Glu Glu Asp Leu1395 1400
1405ttt aac cca tgc cag gcg atc aag tgc aag cat ggg aag tgc agg ctt
4272Phe Asn Pro Cys Gln Ala Ile Lys Cys Lys His Gly Lys Cys Arg
Leu1410 1415 1420tca ggt ctg ggg cag ccc tac tgt gaa tgc agc agt
gga tac acg ggg 4320Ser Gly Leu Gly Gln Pro Tyr Cys Glu Cys Ser Ser
Gly Tyr Thr Gly1425 1430 1435 1440gac agc tgt gat cga gaa atc tct
tgt cga ggg gaa agg ata aga gat 4368Asp Ser Cys Asp Arg Glu Ile Ser
Cys Arg Gly Glu Arg Ile Arg Asp1445 1450 1455tat tac caa aag cag
cag ggc tat gct gct tgc caa aca acc aag aag 4416Tyr Tyr Gln Lys Gln
Gln Gly Tyr Ala Ala Cys Gln Thr Thr Lys Lys1460 1465 1470gtg tcc
cga tta gag tgc aga ggt ggg tgt gca gga ggg cag tgc tgt 4464Val Ser
Arg Leu Glu Cys Arg Gly Gly Cys Ala Gly Gly Gln Cys Cys1475 1480
1485gga ccg ctg agg agc aag cgg cgg aaa tac tct ttc gaa tgc act gac
4512Gly Pro Leu Arg Ser Lys Arg Arg Lys Tyr Ser Phe Glu Cys Thr
Asp1490 1495 1500ggc tcc tcc ttt gtg gac gag gtt gag aaa gtg gtg
aag tgc ggc tgt 4560Gly Ser Ser Phe Val Asp Glu Val Glu Lys Val Val
Lys Cys Gly Cys1505 1510 1515 1520acg agg tgt gtg tcc taaacacact
cccggcagct ctgtctttgg aaaaggttgt 4615Thr Arg Cys Val
Ser1525atacttcttg accatgtggg actaatgaat gcttcatagt ggaaatattt
gaaatatatt 4675gtaaaataca gaacagactt atttttatta tgagaataaa
gacttttttt ctgcatttgg 4735aaaaaaaaaa aaaaaaaact cga
475821525PRThuman 2Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser
Leu Gly Leu Val 1 5 10 15Leu Ala Ile Leu Asn Lys Val Ala Pro Gln
Ala Cys Pro Ala Gln Cys20 25 30Ser Cys Ser Gly Ser Thr Val Asp Cys
His Gly Leu Ala Leu Arg Ser35 40 45Val Pro Arg Asn Ile Pro Arg Asn
Thr Glu Arg Leu Asp Leu Asn Gly50 55 60Asn Asn Ile Thr Arg Ile Thr
Lys Thr Asp Phe Ala Gly Leu Arg His65 70 75
80Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg85
90 95Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn
Arg100 105 110Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly
Thr Ala Lys115 120 125Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile
Gln Ala Ile Pro Arg130 135 140Lys Ala Phe Arg Gly Ala Val Asp Ile
Lys Asn Leu Gln Leu Asp Tyr145 150 155 160Asn Gln Ile Ser Cys Ile
Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp165 170 175Leu Glu Val Leu
Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val180 185 190Ala Ser
Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser195 200
205Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp
Leu210 215 220Arg Lys Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met
Gly Pro Ser225 230 235 240His Leu Arg Gly His Asn Val Ala Glu Val
Gln Lys Arg Glu Phe Val245 250 255Cys Ser Asp Glu Glu Glu Gly His
Gln Ser Phe Met Ala Pro Ser Cys260 265 270Ser Val Leu His Cys Pro
Ala Ala Cys Thr Cys Ser Asn Asn Ile Val275 280 285Asp Cys Arg Gly
Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu290 295 300Thr Ile
Thr Glu Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro305 310 315
320Pro Gly Ala Phe Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu
Ser325 330 335Asn Asn Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln
Gly Leu Arg340 345 350Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys
Ile Thr Glu Leu Pro355 360 365Lys Ser Leu Phe Glu Gly Leu Phe Ser
Leu Gln Leu Leu Leu Leu Asn370 375 380Ala Asn Lys Ile Asn Cys Leu
Arg Val Asp Ala Phe Gln Asp Leu His385 390 395 400Asn Leu Asn Leu
Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala405 410 415Lys Gly
Thr Phe Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala420 425
430Gln Asn Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp
Tyr435 440 445Leu His Thr Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys
Thr Ser Pro450 455 460Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile
Lys Ser Lys Lys Phe465 470 475 480Arg Cys Ser Gly Thr Glu Asp Tyr
Arg Ser Lys Leu Ser Gly Asp Cys485 490 495Phe Ala Asp Leu Ala Cys
Pro Glu Lys Cys Arg Cys Glu Gly Thr Thr500 505 510Val Asp Cys Ser
Asn Gln Lys Leu Asn Lys Ile Pro Glu His Ile Pro515 520 525Gln Tyr
Thr Ala Glu Leu Arg Leu Asn Asn Asn Glu Phe Thr Val Leu530 535
540Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Gln Leu Arg Lys Ile
Asn545 550 555 560Phe Ser Asn Asn Lys Ile Thr Asp Ile Glu Glu Gly
Ala Phe Glu Gly565 570 575Ala Ser Gly Val Asn Glu Ile Leu Leu Thr
Ser Asn Arg Leu Glu Asn580 585 590Val Gln His Lys Met Phe Lys Gly
Leu Glu Ser Leu Lys Thr Leu Met595 600 605Leu Arg Ser Asn Arg Ile
Thr Cys Val Gly Asn Asp Ser Phe Ile Gly610 615 620Leu Ser Ser Val
Arg Leu Leu Ser Leu Tyr Asp Asn Gln Ile Thr Thr625 630 635 640Val
Ala Pro Gly Ala Phe Asp Thr Leu His Ser Leu Ser Thr Leu Asn645 650
655Leu Leu Ala Asn Pro Phe Asn Cys Asn Cys Tyr Leu Ala Trp Leu
Gly660 665 670Glu Trp Leu Arg Lys Lys Arg Ile Val Thr Gly Asn Pro
Arg Cys Gln675 680 685Lys Pro Tyr Phe Leu Lys Glu Ile Pro Ile Gln
Asp Val Ala Ile Gln690 695 700Asp Phe Thr Cys Asp Asp Gly Asn Asp
Asp Asn Ser Cys Ser Pro Leu705 710 715 720Ser Arg Cys Pro Thr Glu
Cys Thr Cys Leu Asp Thr Val Val Arg Cys725 730 735Ser Asn Lys Gly
Leu Lys Val Leu Pro Lys Gly Ile Pro Arg Asp Val740 745 750Thr Glu
Leu Tyr Leu Asp Gly Asn Gln Phe Thr Leu Val Pro Lys Glu755 760
765Leu Ser Asn Tyr Lys His Leu Thr Leu Ile Asp Leu Ser Asn Asn
Arg770 775 780Ile Ser Thr Leu Ser Asn Gln Ser Phe Ser Asn Met Thr
Gln Leu Leu785 790 795 800Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg
Cys Ile Pro Pro Arg Thr805 810 815Phe Asp Gly Leu Lys Ser Leu Arg
Leu Leu Ser Leu His Gly Asn Asp820 825 830Ile Ser Val Val Pro Glu
Gly Ala Phe Asn Asp Leu Ser Ala Leu Ser835 840 845His Leu Ala Ile
Gly Ala Asn Pro Leu Tyr Cys Asp Cys Asn Met Gln850 855 860Trp Leu
Ser Asp Trp Val Lys Ser Glu Tyr Lys Glu Pro Gly Ile Ala865 870 875
880Arg Cys Ala Gly Pro Gly Glu Met Ala Asp Lys Leu Leu Leu Thr
Thr885 890 895Pro Ser Lys Lys Phe Thr Cys Gln Gly Pro Val Asp Val
Asn Ile Leu900 905 910Ala Lys Cys Asn Pro Cys Leu Ser Asn Pro Cys
Lys Asn Asp Gly Thr915 920 925Cys Asn Ser Asp Pro Val Asp Phe Tyr
Arg Cys Thr Cys Pro Tyr Gly930 935 940Phe Lys Gly Gln Asp Cys Asp
Val Pro Ile His Ala Cys Ile Ser Asn945 950 955 960Pro Cys Lys His
Gly Gly Thr Cys His Leu Lys Glu Gly Glu Glu Asp965 970 975Gly Phe
Trp Cys Ile Cys Ala Asp Gly Phe Glu Gly Glu Asn Cys Glu980 985
990Val Asn Val Asp Asp Cys Glu Asp Asn Asp Cys Glu Asn Asn Ser
Thr995 1000 1005Cys Val Asp Gly Ile Asn Asn Tyr Thr Cys Leu Cys Pro
Pro Glu Tyr1010 1015 1020Thr Gly Glu Leu Cys Glu Glu Lys Leu Asp
Phe Cys Ala Gln Asp Leu1025 1030 1035 1040Asn Pro Cys Gln His Asp
Ser Lys Cys Ile Leu Thr Pro Lys Gly Phe1045 1050 1055Lys Cys Asp
Cys Thr Pro Gly Tyr Val Gly Glu His Cys Asp Ile Asp1060 1065
1070Phe Asp Asp Cys Gln Asp Asn Lys Cys Lys Asn Gly Ala His Cys
Thr1075 1080 1085Asp Ala Val Asn Gly Tyr Thr Cys Ile Cys Pro Glu
Gly Tyr Ser Gly1090 1095 1100Leu Phe Cys Glu Phe Ser Pro Pro Met
Val Leu Pro Arg Thr Ser Pro1105 1110 1115 1120Cys Asp Asn Phe Asp
Cys Gln Asn Gly Ala Gln Cys Ile Val Arg Ile1125 1130 1135Asn Glu
Pro Ile Cys Gln Cys Leu Pro Gly Tyr Gln Gly Glu Lys Cys1140 1145
1150Glu Lys Leu Val Ser Val Asn Phe Ile Asn Lys Glu Ser Tyr Leu
Gln1155 1160 1165Ile Pro Ser Ala Lys Val Arg Pro Gln Thr Asn Ile
Thr Leu Gln Ile1170 1175 1180Ala Thr Asp Glu Asp Ser Gly Ile Leu
Leu Tyr Lys Gly Asp Lys Asp1185 1190 1195 1200His Ile Ala Val Glu
Leu Tyr Arg Gly Arg Val Arg Ala Ser Tyr Asp1205 1210 1215Thr Gly
Ser His Pro Ala Ser Ala Ile Tyr Ser Val Glu Thr Ile Asn1220 1225
1230Asp Gly Asn Phe His Ile Val Glu Leu Leu Ala Leu Asp Gln Ser
Leu1235 1240 1245Ser Leu Ser Val Asp Gly Gly Asn Pro Lys Ile Ile
Thr Asn Leu Ser1250 1255 1260Lys Gln Ser Thr Leu Asn Phe Asp Ser
Pro Leu Tyr Val Gly Gly Met1265 1270 1275 1280Pro Gly Lys Ser Asn
Val Ala Ser Leu Arg Gln Ala Pro Gly Gln Asn1285 1290 1295Gly Thr
Ser Phe His Gly Cys Ile Arg Asn Leu Tyr Ile Asn Ser Glu1300 1305
1310Leu Gln Asp Phe Gln Lys Val Pro Met Gln Thr Gly Ile Leu Pro
Gly1315 1320 1325Cys Glu Pro Cys His Lys Lys Val Cys Ala His Gly
Thr Cys Gln Pro1330 1335 1340Ser Ser Gln Ala Gly Phe Thr Cys Glu
Cys Gln Glu Gly Trp Met Gly1345 1350 1355 1360Pro Leu Cys Asp Gln
Arg Thr Asn Asp Pro Cys Leu Gly Asn Lys Cys1365 1370 1375Val His
Gly Thr Cys Leu Pro Ile Asn Ala Phe Ser Tyr Ser Cys Lys1380 1385
1390Cys Leu Glu Gly His Gly Gly Val Leu Cys Asp Glu Glu Glu Asp
Leu1395 1400 1405Phe Asn Pro Cys Gln Ala Ile Lys Cys Lys His Gly
Lys Cys Arg Leu1410 1415 1420Ser Gly Leu Gly Gln Pro Tyr Cys Glu
Cys Ser Ser Gly Tyr Thr Gly1425 1430 1435 1440Asp Ser Cys Asp Arg
Glu Ile Ser Cys Arg Gly Glu Arg Ile Arg Asp1445 1450 1455Tyr Tyr
Gln Lys Gln Gln Gly Tyr Ala Ala Cys Gln Thr Thr Lys Lys1460 1465
1470Val Ser Arg Leu Glu Cys Arg Gly Gly Cys Ala Gly Gly Gln Cys
Cys1475 1480 1485Gly Pro Leu Arg Ser Lys Arg Arg Lys Tyr Ser Phe
Glu Cys Thr Asp1490 1495 1500Gly Ser Ser Phe Val Asp Glu Val Glu
Lys Val Val Lys Cys Gly Cys1505 1510 1515 1520Thr Arg Cys Val
Ser15253105PRThuman 3Ser Pro Cys Thr Cys Ser Asn Asn Ile Val Asp
Cys Arg Gly Lys Gly 1 5 10 15Leu Met Glu Ile Pro Ala Asn Leu Pro
Glu Gly Ile Val Glu Ile Arg20 25 30Leu Glu Gln Asn Ser Ile Lys Ala
Ile Pro Ala Gly Ala Phe Thr Gln35 40 45Tyr Lys Lys Leu Lys Arg Ile
Asp Ile Ser Lys Asn Gln Ile Ser Asp50 55 60Ile Ala Pro Asp Ala Phe
Gln Gly Leu Lys Ser Leu Thr Ser Leu Val65 70 75 80Leu Tyr Gly Asn
Lys Ile Thr Glu Ile Ala Lys Gly Leu Phe Asp Gly85 90 95Leu Val Ser
Leu Gln Leu Leu Leu Leu100 1054138PRThuman 4Glu Gly Ala Phe Asn Gly
Ala Ala Ser Val Gln Glu Leu Met Leu Thr1 5 10 15Gly Asn Gln Leu Glu
Thr Val His Gly Arg Gly Phe Arg Gly Gly Leu20 25 30Ser Gly Leu Lys
Thr Leu Met Leu Arg Ser Asn Leu Ile Gly Cys Val35 40 45Ser Asn Asp
Thr Phe Ala Gly Leu Ser Ser Val Arg Leu Leu Ser Leu50 55 60Tyr Asp
Asn Arg Ile Thr Thr Ile Thr Pro Gly Ala Phe Thr Thr Leu65 70 75
80Val Ser Leu Ser Thr Ile Asn Leu Leu Ser Asn Pro Phe Asn Cys Asn85
90 95Cys His Leu Gly Ala Gly Leu Gly Lys Trp Leu Arg Lys Arg Arg
Ile100 105 110Val Ser Gly Asn Pro Arg Cys Gln Lys Pro Phe Phe Leu
Lys Glu Ile115 120 125Pro Ile Gln Gly Val Gly His Pro Gly Ile130
1355160PRThumanmisc_feature(121)..(150)note="Xaa signifies gap in
sequence" 5Trp Pro Arg Cys Glu Cys Met Pro Gly Tyr Ala Gly Asp Asn
Cys Ser1 5 10 15Glu Asn Gln Asp Asp Cys Arg Asp His Arg Cys Gln Asn
Gly Ala Gln20 25 30Cys Met Asp Glu Val Asn Ser Tyr Ser Cys Leu Cys
Ala Glu Gly Tyr35 40 45Ser Gly Gln Leu Cys Glu Ile Pro Pro His Leu
Pro Ala Pro Lys Ser50 55 60Pro Cys Glu Gly Thr Glu Cys Gln Asn Gly
Ala Asn Cys Val Asp Gln65 70 75 80Gly Asn Arg Pro Val Cys Gln Cys
Leu Pro Gly Phe Gly Gly Pro Glu85 90 95Cys Glu Lys Leu Leu Ser Val
Asn Phe Val Asp Arg Asp Thr Tyr Leu100 105 110Gln Phe Thr Asp Leu
Gln Asn Trp Xaa Arg Xaa Asn Ile Thr Leu Gln115 120 125Val Phe Thr
Ala Glu Asp Asn Gly Ile Leu Leu Tyr Asn Gly Gly Asn130 135 140Asp
His Ile Ala Val Xaa Leu Tyr Xaa Gly His Val Arg Phe Ser Tyr145 150
155 1606103PRThuman 6Gln Cys His Ile Ser Asp Gln Gly Glu Pro Tyr
Cys Leu Cys Gln Pro1 5 10 15Gly Phe Ser Gly Glu His Cys Gln Gln Glu
Asn Pro Cys Leu Gly Gln20 25 30Val Val Arg Glu Val Ile Arg Arg Gln
Lys Gly Tyr Ala Ser Cys Ala35 40 45Thr Ala Ser Lys Val Pro Ile Met
Glu Cys Arg Gly Gly Cys Gly Pro50 55 60Gln Cys Cys Gln Pro Thr Arg
Ser Lys Arg Arg Lys Tyr Val Phe Gln65 70 75 80Cys Thr Asp Gly Ser
Ser Phe Val Glu Glu Val Glu Arg His Leu Glu85 90 95Cys Gly Cys Leu
Ala Cys Ser10071480PRTDrosophila melanogaster 7Met Ala Ala Pro Ser
Arg Thr Thr Leu Met Pro Pro Pro Phe Arg Leu1 5 10 15Gln Leu Arg Leu
Leu Ile Leu Pro Ile Leu Leu Leu Leu Arg His Asp20 25 30Ala Val His
Ala Glu Pro Tyr Ser Gly Gly Phe Gly Ser Ser Ala Val35 40 45Ser Ser
Gly Gly Leu Gly Ser Val Gly Ile His Ile Pro Gly Gly Gly50 55 60Val
Gly Val Ile Thr Glu Ala Arg Cys Pro Arg Val Cys Ser Cys Thr65 70 75
80Gly Leu Asn Val Asp Cys Ser His Arg Gly Leu Thr Ser Val Pro Arg85
90 95Lys Ile Ser Ala Asp Val Glu Arg Leu Glu Leu Gln Gly Asn Asn
Leu100 105 110Thr Val Ile Tyr Glu Thr Asp Phe Gln Arg Leu Thr Lys
Leu Arg Met115 120 125Leu Gln Leu Thr Asp Asn Gln Ile His Thr Ile
Glu Arg Asn Ser Phe130 135 140Gln Asp Leu Val Ser Leu Glu Arg Leu
Asp Ile Ser Asn Asn Val Ile145 150 155 160Thr Thr Val Gly Arg Arg
Val Phe Lys Gly Ala Gln Ser Leu Arg Ser165 170 175Leu Gln Leu Asp
Asn Asn Gln Ile Thr Cys Leu Asp Glu His Ala Phe180 185 190Lys Gly
Leu Val Glu Leu Glu Ile Leu Thr Leu Asn Asn Asn Asn Leu195 200
205Thr Ser Leu Pro His Asn Ile Phe Gly Gly Leu Gly Arg Leu Arg
Ala210 215 220Leu Arg Leu Ser Asp Asn Pro Phe Ala Cys Asp Cys His
Leu Ser Trp225 230 235 240Leu Ser Arg Phe Leu Arg Ser Ala Thr Arg
Leu Ala Pro Tyr Thr Arg245 250 255Cys Gln Ser Pro Ser Gln Leu Lys
Gly Gln Asn Val Ala Asp Leu His260 265 270Asp Gln Glu Phe Lys Cys
Ser Gly Leu Thr Glu His Ala Pro Met Glu275 280 285Cys Gly Ala Glu
Asn Ser Cys Pro His Pro Cys Arg Cys Ala Asp Gly290 295 300Ile Val
Asp Cys Arg Glu Lys Ser Leu Thr Ser Val Pro Val Thr Leu305 310 315
320Pro Asp Asp Thr Thr Asp Val Arg Leu Glu Gln Asn Phe Ile Thr
Glu325 330 335Leu Pro Pro Lys Ser Phe Ser Ser Phe Arg Arg Leu Arg
Arg Ile Asp340 345 350Leu Ser Asn Asn Asn Ile Ser Arg Ile Ala His
Asp Ala Leu Ser Gly355 360 365Leu Lys Gln Leu Thr Thr Leu Val Leu
Tyr Gly Asn Lys Ile Lys Asp370 375 380Leu Pro Ser Gly Val Phe Lys
Gly Leu Gly Ser Leu Arg Leu Leu Leu385 390 395 400Leu Asn Ala Asn
Glu Ile Ser Cys Ile Arg Lys Asp Ala Phe Arg Asp405 410 415Leu His
Ser Leu Ser Leu Leu Ser Leu Tyr Asp Asn Asn Ile Gln Ser420 425
430Leu Ala Asn Gly Thr Phe Asp Ala Met Lys Ser Met Lys Thr Val
His435 440 445Leu Ala Lys Asn Pro Phe Ile Cys Asp Cys Asn Leu Arg
Trp Leu Ala450 455 460Asp Tyr Leu His Lys Asn Pro Ile Glu Thr Ser
Gly Ala Arg Cys Glu465 470 475 480Ser Pro Lys Arg Met His Arg Arg
Arg Ile Glu Ser Leu Arg Glu Glu485 490 495Lys Phe Lys Cys Ser Trp
Gly Glu Leu Arg Met Lys Leu Ser Gly Glu500 505 510Cys Arg Met Asp
Ser Asp Cys Pro Ala Met Cys His Cys Glu Gly Thr515 520 525Thr Val
Asp Cys Thr Gly Arg Arg Leu Lys Glu Ile Pro Arg Asp Ile530 535
540Pro Leu His Thr Thr Glu Leu Leu Leu Asn Asp Asn Glu Leu Gly
Arg545 550 555 560Ile Ser Ser Asp Gly Leu Phe Gly Arg Leu Pro His
Leu Val Lys Leu565 570 575Glu Leu Lys Arg Asn Gln Leu Thr Gly Ile
Glu Pro Asn Ala Phe Glu580 585 590Gly Ala Ser His Ile Gln Glu Leu
Gln Leu Gly Glu Asn Lys Ile Lys595 600 605Glu Ile Ser Asn Lys Met
Phe Leu Gly Leu His Gln Leu Lys Thr Leu610 615 620Asn Leu Tyr Asp
Asn Gln Ile Ser Cys Val Met Pro Gly Ser Phe Glu625 630 635 640His
Leu Asn Ser Leu Thr Ser Leu Asn Leu Ala Ser Asn Pro Phe Asn645 650
655Cys Asn Cys His Leu Ala Trp Phe Ala Glu Cys Val Arg Lys Lys
Ser660 665 670Leu Asn Gly Gly Ala Ala Arg Cys Gly Ala Pro Ser Lys
Val Arg
Asp675 680 685Val Gln Ile Lys Asp Leu Pro His Ser Glu Phe Lys Cys
Ser Ser Glu690 695 700Asn Ser Glu Gly Cys Leu Gly Asp Gly Tyr Cys
Pro Pro Ser Cys Thr705 710 715 720Cys Thr Gly Thr Val Val Ala Cys
Ser Arg Asn Gln Leu Lys Glu Ile725 730 735Pro Arg Gly Ile Pro Ala
Glu Thr Ser Glu Leu Tyr Leu Glu Ser Asn740 745 750Glu Ile Glu Gln
Ile His Tyr Glu Arg Ile Arg His Leu Arg Ser Leu755 760 765Thr Arg
Leu Asp Leu Ser Asn Asn Gln Ile Thr Ile Leu Ser Asn Tyr770 775
780Thr Phe Ala Asn Leu Thr Lys Leu Ser Thr Leu Ile Ile Ser Tyr
Asn785 790 795 800Lys Leu Gln Cys Leu Gln Arg His Ala Leu Ser Gly
Leu Asn Asn Leu805 810 815Arg Val Val Ser Leu His Gly Asn Arg Ile
Ser Met Leu Pro Glu Gly820 825 830Ser Phe Glu Asp Leu Lys Ser Leu
Thr His Ile Ala Leu Gly Ser Asn835 840 845Pro Leu Tyr Cys Asp Cys
Gly Leu Lys Trp Phe Ser Asp Trp Ile Lys850 855 860Leu Asp Tyr Val
Glu Pro Gly Ile Ala Arg Cys Ala Glu Pro Glu Gln865 870 875 880Met
Lys Asp Lys Leu Ile Leu Ser Thr Pro Ser Ser Ser Phe Val Cys885 890
895Arg Gly Arg Val Arg Asn Asp Ile Leu Ala Lys Cys Asn Ala Cys
Phe900 905 910Glu Gln Pro Cys Gln Asn Gln Ala Gln Cys Val Ala Leu
Pro Gln Arg915 920 925Glu Tyr Gln Cys Leu Cys Gln Pro Gly Tyr His
Gly Lys His Cys Glu930 935 940Phe Met Ile Asp Ala Cys Tyr Gly Asn
Pro Cys Arg Asn Asn Ala Thr945 950 955 960Cys Thr Val Leu Glu Glu
Gly Arg Phe Ser Cys Gln Cys Ala Pro Gly965 970 975Tyr Thr Gly Ala
Arg Cys Glu Thr Asn Ile Asp Asp Cys Leu Gly Glu980 985 990Ile Lys
Cys Gln Asn Asn Ala Thr Cys Ile Asp Gly Val Glu Ser Tyr995 1000
1005Lys Cys Glu Cys Gln Pro Gly Phe Ser Gly Glu Phe Cys Asp Thr
Lys1010 1015 1020Ile Gln Phe Cys Ser Pro Glu Phe Asn Pro Cys Ala
Asn Gly Ala Lys1025 1030 1035 1040Cys Met Asp His Phe Thr His Tyr
Ser Cys Asp Cys Gln Ala Gly Phe1045 1050 1055His Gly Thr Asn Cys
Thr Asp Asn Ile Asp Asp Cys Gln Asn His Met1060 1065 1070Cys Gln
Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Asp Tyr Gln Cys1075 1080
1085Arg Cys Pro Asp Asp Tyr Thr Gly Lys Tyr Cys Glu Gly His Asn
Met1090 1095 1100Ile Ser Met Met Tyr Pro Gln Thr Ser Pro Cys Gln
Asn His Glu Cys1105 1110 1115 1120Lys His Gly Val Cys Phe Gln Pro
Asn Ala Gln Gly Ser Asp Tyr Leu1125 1130 1135Cys Arg Cys His Pro
Gly Tyr Thr Gly Lys Trp Cys Glu Tyr Leu Thr1140 1145 1150Ser Ile
Ser Phe Val His Asn Asn Ser Phe Val Glu Leu Glu Pro Leu1155 1160
1165Arg Thr Arg Pro Glu Ala Asn Val Thr Ile Val Phe Ser Ser Ala
Glu1170 1175 1180Gln Asn Gly Ile Leu Met Tyr Asp Gly Gln Asp Ala
His Leu Ala Val1185 1190 1195 1200Glu Leu Phe Asn Gly Arg Ile Arg
Val Ser Tyr Asp Val Gly Asn His1205 1210 1215Pro Val Ser Thr Met
Tyr Ser Phe Glu Met Val Ala Asp Gly Lys Tyr1220 1225 1230His Ala
Val Glu Leu Leu Ala Ile Lys Lys Asn Phe Thr Leu Arg Val1235 1240
1245Asp Arg Gly Leu Ala Arg Ser Ile Ile Asn Glu Gly Ser Asn Asp
Tyr1250 1255 1260Leu Lys Leu Thr Thr Pro Met Phe Leu Gly Gly Leu
Pro Val Asp Pro1265 1270 1275 1280Ala Gln Gln Ala Tyr Lys Asn Trp
Gln Ile Arg Asn Leu Thr Ser Phe1285 1290 1295Lys Gly Cys Met Lys
Glu Val Trp Ile Asn His Lys Leu Val Asp Phe1300 1305 1310Gly Asn
Ala Gln Arg Gln Gln Lys Ile Thr Pro Gly Cys Ala Leu Leu1315 1320
1325Glu Gly Glu Gln Gln Glu Glu Glu Asp Asp Glu Gln Asp Phe Met
Asp1330 1335 1340Glu Thr Pro His Ile Lys Glu Glu Pro Val Asp Pro
Cys Leu Glu Asn1345 1350 1355 1360Lys Cys Arg Arg Gly Ser Arg Cys
Val Pro Asn Ser Asn Ala Arg Asp1365 1370 1375Gly Tyr Gln Cys Lys
Cys Lys His Gly Gln Arg Gly Arg Tyr Cys Asp1380 1385 1390Gln Gly
Glu Gly Ser Thr Glu Pro Pro Thr Val Thr Ala Ala Ser Thr1395 1400
1405Cys Arg Lys Glu Gln Val Arg Glu Tyr Tyr Thr Glu Asn Asp Cys
Arg1410 1415 1420Ser Arg Gln Pro Leu Lys Tyr Ala Lys Cys Val Gly
Gly Cys Gly Asn1425 1430 1435 1440Gln Cys Cys Ala Ala Lys Ile Val
Arg Arg Arg Lys Val Arg Met Val1445 1450 1455Cys Ser Asn Asn Arg
Lys Tyr Ile Lys Asn Leu Asp Ile Val Arg Lys1460 1465 1470Cys Gly
Cys Thr Lys Lys Cys Tyr1475 14808155PRTCaenorhabditis
elegansmisc_feature(4)..(152)note="Xaa signifies gap in sequence"
8Arg Asn Pro Xaa Ile Cys Asp Cys Asn Leu Gln Trp Leu Ala Gln Ile1 5
10 15Asn Leu Gln Lys Asn Ile Glu Thr Ser Gly Ala Arg Cys Glu Gln
Pro20 25 30Lys Arg Leu Arg Lys Lys Lys Phe Ala Thr Leu Pro Pro Asn
Lys Phe35 40 45Lys Cys Lys Gly Ser Glu Ser Phe Val Ser Met Tyr Ala
Asp Ser Cys50 55 60Phe Ile Asp Ser Ile Cys Pro Thr Gln Cys Asp Cys
Tyr Gly Thr Thr65 70 75 80Val Asp Cys Asn Lys Arg Gly Leu Asn Thr
Ile Pro Thr Ser Ile Pro85 90 95Arg Phe Ala Thr Gln Leu Leu Leu Ser
Gly Asn Asn Ile Ser Thr Val100 105 110Asp Leu Asn Ser Asn Ile His
Val Leu Glu Asn Leu Glu Xaa Leu Asp115 120 125Leu Ser Asn Asn His
Ile Thr Phe Ile Asn Asp Lys Ser Phe Glu Lys130 135 140Leu Ser Lys
Leu Arg Glu Leu Xaa Leu Asn Asp145 150 1559735PRTCaenorhabditis
elegans 9Ser Asn Lys Asn Leu Thr Ser Phe Pro Ser Arg Ile Pro Phe
Asp Thr1 5 10 15Thr Glu Leu Tyr Leu Asp Ala Asn Tyr Ile Asn Glu Ile
Pro Ala His20 25 30Asp Leu Asn Arg Leu Tyr Ser Leu Thr Lys Leu Asp
Leu Ser His Asn35 40 45Arg Leu Ile Ser Leu Glu Asn Asn Thr Phe Ser
Asn Leu Thr Arg Leu50 55 60Ser Thr Leu Ile Ile Ser Tyr Asn Lys Leu
Arg Cys Leu Gln Pro Leu65 70 75 80Ala Phe Asn Gly Leu Asn Ala Leu
Arg Ile Leu Ser Leu His Gly Asn85 90 95Asp Ile Ser Phe Leu Pro Gln
Ser Ala Phe Ser Asn Leu Thr Ser Ile100 105 110Thr His Ile Ala Val
Gly Ser Asn Ser Leu Tyr Cys Asp Cys Asn Met115 120 125Ala Trp Phe
Ser Lys Trp Ile Lys Ser Lys Phe Ile Glu Ala Gly Ile130 135 140Ala
Arg Cys Glu Tyr Pro Asn Thr Val Ser Asn Gln Leu Leu Leu Thr145 150
155 160Ala Gln Pro Tyr Gln Phe Thr Cys Asp Ser Lys Val Pro Thr Lys
Leu165 170 175Ala Thr Lys Cys Asp Leu Cys Leu Asn Ser Pro Cys Lys
Asn Asn Ala180 185 190Ile Cys Glu Thr Thr Ser Ser Arg Lys Tyr Thr
Cys Asn Cys Thr Pro195 200 205Gly Phe Tyr Gly Val His Cys Glu Asn
Gln Ile Asp Ala Cys Tyr Gly210 215 220Ser Pro Cys Leu Asn Asn Ala
Thr Cys Lys Val Ala Gln Ala Gly Arg225 230 235 240Phe Asn Cys Tyr
Cys Asn Lys Gly Phe Glu Gly Asp Tyr Cys Glu Lys245 250 255Asn Ile
Asp Asp Cys Val Asn Ser Lys Cys Glu Asn Gly Gly Lys Cys260 265
270Val Asp Leu Val Arg Phe Cys Ser Glu Glu Leu Lys Asn Phe Gln
Ser275 280 285Phe Gln Ile Asn Ser Tyr Arg Cys Asp Cys Pro Met Glu
Tyr Glu Gly290 295 300Lys His Cys Glu Asp Lys Leu Glu Tyr Cys Thr
Lys Lys Leu Asn Pro305 310 315 320Cys Glu Asn Asn Gly Lys Cys Ile
Pro Ile Asn Gly Ser Tyr Ser Cys325 330 335Met Cys Ser Pro Gly Phe
Thr Gly Asn Asn Cys Glu Thr Asn Ile Asp340 345 350Asp Cys Lys Asn
Val Glu Cys Gln Asn Gly Gly Ser Cys Val Asp Gly355 360 365Ile Leu
Ser Tyr Asp Cys Leu Cys Arg Pro Gly Tyr Ala Gly Gln Tyr370 375
380Cys Glu Ile Pro Pro Met Met Asp Met Glu Tyr Gln Lys Thr Asp
Ala385 390 395 400Cys Gln Gln Ser Ala Cys Gly Gln Gly Glu Cys Val
Ala Ser Gln Asn405 410 415Ser Ser Asp Phe Thr Cys Lys Cys His Glu
Gly Phe Ser Gly Pro Ser420 425 430Cys Asp Arg Gln Met Ser Val Gly
Phe Lys Asn Pro Gly Ala Tyr Leu435 440 445Ala Leu Asp Pro Leu Ala
Ser Asp Gly Thr Ile Thr Met Thr Leu Arg450 455 460Thr Thr Ser Lys
Ile Gly Ile Leu Leu Tyr Tyr Gly Asp Asp His Phe465 470 475 480Val
Ser Ala Glu Leu Tyr Asp Gly Arg Val Lys Leu Val Tyr Tyr Ile485 490
495Gly Asn Phe Pro Ala Ser His Met Tyr Ser Ser Val Lys Val Asn
Asp500 505 510Gly Leu Pro His Arg Ile Ser Ile Arg Thr Ser Glu Arg
Lys Cys Phe515 520 525Leu Gln Ile Asp Lys Asn Pro Val Gln Ile Val
Glu Asn Ser Gly Lys530 535 540Ser Asp Gln Leu Ile Thr Lys Gly Lys
Glu Met Leu Tyr Ile Gly Gly545 550 555 560Leu Pro Ile Glu Lys Ser
Gln Asp Ala Lys Arg Arg Phe His Val Lys565 570 575Asn Ser Glu Ser
Leu Lys Gly Cys Ile Ser Ser Ile Thr Ile Asn Glu580 585 590Val Pro
Ile Asn Leu Gln Gln Ala Leu Glu Asn Val Asn Thr Glu Gln595 600
605Ser Cys Ser Ala Thr Val Asn Phe Cys Ala Gly Ile Asp Cys Gly
Asn610 615 620Gly Lys Cys Thr Asn Asn Ala Leu Ser Pro Lys Gly Tyr
Met Cys Gln625 630 635 640Cys Asp Ser His Phe Ser Gly Glu His Cys
Asp Glu Lys Arg Ile Lys645 650 655Cys Asp Lys Gln Lys Phe Arg Arg
His His Ile Glu Asn Glu Cys Arg660 665 670Ser Val Asp Arg Ile Lys
Ile Ala Glu Cys Asn Gly Tyr Cys Gly Gly675 680 685Glu Gln Asn Cys
Cys Thr Ala Val Lys Lys Lys Gln Arg Lys Val Lys690 695 700Met Ile
Cys Lys Asn Gly Thr Thr Lys Ile Ser Thr Val His Ile Ile705 710 715
720Arg Gln Cys Gln Cys Glu Pro Thr Lys Ser Val Leu Ser Glu Lys725
730 73510154PRTmouse 10Asp Pro Leu Pro Val His His Arg Cys Glu Cys
Met Leu Gly Tyr Thr1 5 10 15Gly Asp Asn Cys Ser Glu Asn Gln Asp Asp
Cys Lys Asp His Lys Cys20 25 30Gln Asn Gly Ala Gln Cys Val Asp Glu
Val Asn Ser Tyr Ala Cys Leu35 40 45Cys Val Glu Gly Tyr Ser Gly Gln
Leu Cys Glu Ile Pro Pro Ala Pro50 55 60Arg Ser Ser Cys Glu Gly Thr
Glu Cys Gln Asn Gly Ala Asn Cys Val65 70 75 80Asp Gln Gly Ser Arg
Pro Val Cys Gln Cys Leu Pro Gly Phe Gly Gly85 90 95Pro Glu Cys Glu
Lys Leu Leu Ser Val Asn Phe Val Asp Arg Asp Thr100 105 110Tyr Leu
Gln Phe Thr Asp Leu Gln Asn Trp Pro Arg Ala Asn Ile Thr115 120
125Leu Gln Val Ser Thr Ala Glu Asp Asn Gly Ile Leu Leu Tyr Asn
Gly130 135 140Asp Asn Asp His Ile Ala Val Glu Leu Tyr145
15011110PRTmouse 11Ala Phe Lys Cys His His Gly Gln Cys His Ile Ser
Asp Arg Gly Glu1 5 10 15Pro Tyr Cys Leu Cys Gln Pro Gly Phe Ser Gly
His His Cys Glu Gln20 25 30Glu Asn Pro Cys Met Gly Glu Ile Val Arg
Glu Ala Ile Arg Arg Gln35 40 45Lys Asp Tyr Ala Ser Cys Ala Thr Ala
Ser Lys Val Pro Ile Met Glu50 55 60Cys Arg Gly Gly Cys Gly Thr Thr
Cys Cys Gln Pro Ile Arg Ser Lys65 70 75 80Arg Arg Lys Tyr Val Phe
Gln Cys Thr Asp Gly Ser Ser Phe Val Glu85 90 95Glu Val Glu Arg His
Leu Glu Cys Gly Cys Arg Ala Cys Ser100 105 11012134PRTmouse 12His
Leu Arg Val Leu Gln Leu Met Glu Asn Arg Ile Ser Thr Ile Glu1 5 10
15Arg Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn20
25 30Arg Asn Asn Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr
Ala35 40 45Arg Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala
Ile Pro50 55 60Arg Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu
Gln Leu Asp65 70 75 80Tyr Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala
Phe Arg Ala Leu Arg85 90 95Asp Leu Glu Val Leu Thr Leu Asn Asn Asn
Asn Ile Thr Arg Leu Ser100 105 110Val Ala Ser Phe Asn His Met Pro
Lys Leu Arg Thr Phe Arg Leu His115 120 125Ser Asn Asn Leu Tyr
Cys13013104PRTmouse 13Asn Asn Asp Asp Cys Val Gly His Lys Cys Arg
His Gly Ala Gln Cys1 5 10 15Val Asp Glu Val Asn Gly Tyr Thr Cys Ile
Cys Pro Gln Gly Phe Ser20 25 30Gly Leu Phe Cys Glu His Pro Pro Pro
Met Val Leu Leu Gln Thr Ser35 40 45Pro Cys Asp Gln Tyr Glu Cys Gln
Asn Gly Ala Gln Cys Ile Val Val50 55 60Gln Gln Glu Pro Thr Cys Arg
Cys Pro Pro Gly Phe Ala Gly Pro Arg65 70 75 80Cys Glu Lys Leu Ile
Thr Val Asn Phe Val Gly Lys Asp Ser Tyr Val85 90 95Glu Leu Ala Ser
Ala Lys Val Arg10014243PRTmouse 14Ile Leu Asp Val Ala Ser Leu Arg
Gln Ala Pro Gly Glu Asn Gly Thr1 5 10 15Ser Phe His Gly Cys Ile Arg
Asn Leu Tyr Ile Asn Ser Glu Leu Gln20 25 30Asp Phe Arg Lys Met Pro
Met Gln Thr Gly Ile Leu Pro Gly Cys Glu35 40 45Pro Cys His Lys Lys
Val Cys Ala His Gly Cys Cys Gln Pro Ser Ser50 55 60Gln Ser Gly Phe
Thr Cys Glu Cys Glu Glu Gly Trp Met Gly Pro Leu65 70 75 80Cys Asp
Gln Arg Thr Asn Asp Pro Cys Leu Gly Asn Lys Cys Val His85 90 95Gly
Thr Cys Leu Pro Ile Asn Ala Phe Ser Tyr Ser Cys Lys Cys Leu100 105
110Glu Gly His Gly Gly Val Leu Cys Asp Glu Glu Glu Asp Leu Phe
Asn115 120 125Pro Cys Gln Met Ile Lys Cys Lys His Gly Lys Cys Arg
Leu Ser Gly130 135 140Val Gly Gln Pro Tyr Cys Glu Cys Asn Ser Gly
Phe Thr Gly Asp Ser145 150 155 160Cys Asp Arg Glu Ile Ser Cys Arg
Gly Glu Arg Ile Arg Asp Tyr Tyr165 170 175Gln Lys Gln Gln Gly Tyr
Ala Ala Cys Gln Thr Thr Lys Lys Val Ser180 185 190Arg Leu Glu Cys
Arg Gly Gly Cys Ala Gly Gly Gln Cys Cys Gly Pro195 200 205Leu Arg
Ser Lys Arg Arg Lys Tyr Ser Phe Glu Cys Thr Asp Gly Ser210 215
220Ser Phe Val Asp Glu Val Glu Lys Val Val Lys Cys Gly Cys Ala
Arg225 230 235 240Cys Ala Ser151395PRTDrosophila melanogaster 15Met
His Pro Met His Pro Glu Asn His Ala Ile Ala Arg Ser Thr Ser1 5 10
15Thr Thr Asn Asn Pro Ser Arg Ser Arg Ser Ser Arg Met Trp Leu Leu20
25 30Pro Ala Trp Leu Leu Leu Val Leu Val Ala Ser Asn Gly Leu Pro
Ala35 40 45Val Arg Gly Gln Tyr Gln Ser Pro Arg Ile Ile Glu His Pro
Thr Asp50 55 60Leu Val Val Lys Lys Asn Glu Pro Ala Thr Leu Asn Cys
Lys Val Glu65 70 75 80Gly Lys Pro Glu Pro Thr Ile Glu Trp Phe Lys
Asp Gly Glu Pro Val85 90 95Ser Thr Asn Glu Lys Lys Ser His Arg Val
Gln Phe Lys Asp Gly Ala100 105 110Leu Phe Phe Tyr Arg Thr Met Gln
Gly Lys Lys Glu Gln Asp Gly Gly115 120 125Glu Tyr Trp Cys Val Ala
Lys Asn Arg Val Gly Gln Ala Val Ser Arg130 135 140His Ala Ser Leu
Gln Ile Ala Val Leu Arg Asp Asp Phe Arg Val Glu145 150 155 160Pro
Lys Asp Thr Arg Val Ala Lys Gly Glu Thr Ala Leu Leu Glu Cys165 170
175Gly Pro Pro Lys Gly Ile Pro Glu Pro Thr Leu Ile Trp Ile Lys
Asp180
185 190Gly Val Pro Leu Asp Asp Leu Lys Ala Met Ser Phe Gly Ala Ser
Ser195 200 205Arg Val Arg Ile Val Asp Gly Gly Asn Leu Leu Ile Ser
Asn Val Glu210 215 220Pro Ile Asp Glu Gly Asn Tyr Lys Cys Ile Ala
Gln Asn Leu Val Gly225 230 235 240Thr Arg Glu Ser Ser Tyr Ala Lys
Leu Ile Val Gln Val Lys Pro Tyr245 250 255Phe Met Lys Glu Pro Lys
Asp Gln Val Met Leu Tyr Gly Gln Thr Ala260 265 270Thr Phe His Cys
Ser Val Gly Gly Asp Pro Pro Pro Lys Val Leu Trp275 280 285Lys Lys
Glu Glu Gly Asn Ile Pro Val Ser Arg Ala Arg Ile Leu His290 295
300Asp Glu Lys Ser Leu Glu Ile Ser Asn Ile Thr Pro Thr Asp Glu
Gly305 310 315 320Thr Tyr Val Cys Glu Ala His Asn Asn Val Gly Gln
Ile Ser Ala Arg325 330 335Ala Ser Leu Ile Val His Ala Pro Pro Asn
Phe Thr Lys Arg Pro Ser340 345 350Asn Lys Lys Val Gly Leu Asn Gly
Val Val Gln Leu Pro Cys Met Ala355 360 365Ser Gly Asn Pro Pro Pro
Ser Val Phe Trp Thr Lys Glu Gly Val Ser370 375 380Thr Leu Met Phe
Pro Asn Ser Ser His Gly Arg Gln Tyr Val Ala Ala385 390 395 400Asp
Gly Thr Leu Gln Ile Thr Asp Val Arg Gln Glu Asp Glu Gly Tyr405 410
415Tyr Val Cys Ser Ala Phe Ser Val Val Asp Ser Ser Thr Val Arg
Val420 425 430Phe Leu Gln Val Ser Ser Val Asp Glu Arg Pro Pro Pro
Ile Ile Gln435 440 445Ile Gly Pro Ala Asn Gln Thr Leu Pro Lys Gly
Ser Val Ala Thr Leu450 455 460Pro Cys Arg Ala Thr Gly Asn Pro Ser
Pro Arg Ile Lys Trp Phe His465 470 475 480Asp Gly His Ala Val Gln
Ala Gly Asn Arg Tyr Ser Ile Ile Gln Gly485 490 495Ser Ser Leu Arg
Val Asp Asp Leu Gln Leu Ser Asp Ser Gly Thr Tyr500 505 510Thr Cys
Thr Ala Ser Gly Glu Arg Gly Glu Thr Ser Trp Ala Ala Thr515 520
525Leu Thr Val Glu Lys Pro Gly Ser Thr Ser Leu His Arg Ala Ala
Asp530 535 540Pro Ser Thr Tyr Pro Ala Pro Pro Gly Thr Pro Lys Val
Leu Asn Val545 550 555 560Ser Arg Thr Ser Ile Ser Leu Arg Trp Ala
Lys Ser Gln Glu Lys Pro565 570 575Gly Ala Val Gly Pro Ile Ile Gly
Tyr Thr Val Glu Tyr Phe Ser Pro580 585 590Asp Leu Gln Thr Gly Trp
Ile Val Ala Ala His Arg Val Gly Asp Thr595 600 605Gln Val Thr Ile
Ser Gly Leu Thr Pro Gly Thr Ser Tyr Val Phe Leu610 615 620Val Arg
Ala Glu Asn Thr Gln Gly Ile Ser Val Pro Ser Gly Leu Ser625 630 635
640Asn Val Ile Lys Thr Ile Glu Ala Asp Phe Asp Ala Ala Ser Ala
Asn645 650 655Asp Leu Ser Ala Ala Arg Thr Leu Leu Thr Gly Lys Ser
Val Glu Leu660 665 670Ile Asp Ala Ser Ala Ile Asn Ala Ser Ala Val
Arg Leu Glu Trp Met675 680 685Leu His Val Ser Ala Asp Glu Lys Tyr
Val Glu Gly Leu Arg Ile His690 695 700Tyr Lys Asp Ala Ser Val Pro
Ser Ala Gln Tyr His Ser Ile Thr Val705 710 715 720Met Asp Ala Ser
Ala Glu Ser Phe Val Val Gly Asn Leu Lys Lys Tyr725 730 735Thr Lys
Tyr Glu Phe Phe Leu Thr Pro Phe Phe Glu Thr Ile Glu Gly740 745
750Gln Pro Ser Asn Ser Lys Thr Ala Leu Thr Tyr Glu Asp Val Pro
Ser755 760 765Ala Pro Pro Asp Asn Ile Gln Ile Gly Met Tyr Asn Gln
Thr Ala Gly770 775 780Trp Val Arg Trp Thr Pro Pro Pro Ser Gln His
His Asn Gly Asn Leu785 790 795 800Tyr Gly Tyr Lys Ile Glu Val Ser
Ala Gly Asn Thr Met Lys Val Leu805 810 815Ala Asn Met Thr Leu Asn
Ala Thr Thr Thr Ser Val Leu Leu Asn Asn820 825 830Leu Thr Thr Gly
Ala Val Tyr Ser Val Arg Leu Asn Ser Phe Thr Lys835 840 845Ala Gly
Asp Gly Pro Tyr Ser Lys Pro Ile Ser Leu Phe Met Asp Pro850 855
860Thr His His Val His Pro Pro Arg Ala His Pro Ser Gly Thr His
Asp865 870 875 880Gly Arg His Glu Gly Gln Asp Leu Thr Tyr His Asn
Asn Gly Asn Ile885 890 895Pro Pro Gly Asp Ile Asn Pro Thr Thr His
Lys Lys Thr Thr Asp Tyr900 905 910Leu Ser Gly Pro Trp Leu Met Val
Leu Val Cys Ile Val Leu Leu Val915 920 925Leu Val Ile Ser Ala Ala
Ile Ser Met Val Tyr Phe Lys Arg Lys His930 935 940Gln Met Thr Lys
Glu Leu Gly His Leu Ser Val Val Ser Asp Asn Glu945 950 955 960Ile
Thr Ala Leu Asn Ile Asn Ser Lys Glu Ser Leu Trp Ile Asp His965 970
975His Arg Gly Trp Arg Thr Ala Asp Thr Asp Lys Asp Ser Gly Leu
Ser980 985 990Glu Ser Lys Leu Leu Ser His Val Asn Ser Ser Gln Ser
Asn Tyr Asn995 1000 1005Asn Ser Asp Gly Gly Thr Asp Tyr Ala Glu Val
Asp Thr Arg Asn Leu1010 1015 1020Thr Thr Phe Tyr Asn Cys Arg Lys
Ser Pro Asp Asn Pro Thr Pro Tyr1025 1030 1035 1040Ala Thr Thr Met
Ile Ile Gly Thr Ser Ser Ser Glu Thr Cys Thr Lys1045 1050 1055Thr
Thr Ser Ile Ser Ala Asp Lys Asp Ser Gly Thr His Ser Pro Tyr1060
1065 1070Ser Asp Ala Phe Ala Gly Gln Val Pro Ala Val Pro Val Val
Lys Ser1075 1080 1085Asn Tyr Leu Gln Tyr Pro Val Glu Pro Ile Asn
Trp Ser Glu Phe Leu1090 1095 1100Pro Pro Pro Pro Glu His Pro Pro
Pro Ser Ser Thr Tyr Gly Tyr Ala1105 1110 1115 1120Gln Gly Ser Pro
Glu Ser Ser Arg Lys Ser Ser Lys Ser Ala Gly Ser1125 1130 1135Gly
Ile Ser Thr Asn Gln Ser Ile Leu Asn Ala Ser Ile His Ser Ser1140
1145 1150Ser Ser Gly Gly Phe Ser Ala Trp Gly Val Ser Pro Gln Tyr
Ala Val1155 1160 1165Ala Cys Pro Pro Glu Asn Val Tyr Ser Asn Pro
Leu Ser Ala Val Ala1170 1175 1180Gly Gly Thr Gln Asn Arg Tyr Gln
Ile Thr Pro Thr Asn Gln His Pro1185 1190 1195 1200Pro Gln Leu Pro
Ala Tyr Phe Ala Thr Thr Gly Pro Gly Gly Ala Val1205 1210 1215Pro
Pro Asn His Leu Pro Phe Ala Thr Gln Arg His Ala Ala Ser Glu1220
1225 1230Tyr Gln Ala Gly Leu Asn Ala Ala Arg Cys Ala Gln Ser Arg
Ala Cys1235 1240 1245Asn Ser Cys Asp Ala Leu Ala Thr Pro Ser Pro
Met Gln Pro Pro Pro1250 1255 1260Pro Val Pro Val Pro Glu Gly Trp
Tyr Gln Pro Val His Pro Asn Ser1265 1270 1275 1280His Pro Met His
Pro Thr Ser Ser Asn His Gln Ile Tyr Gln Cys Ser1285 1290 1295Ser
Glu Cys Ser Asp His Ser Arg Ser Ser Gln Ser His Lys Arg Gln1300
1305 1310Leu Gln Leu Glu Glu His Gly Ser Ser Ala Lys Gln Arg Gly
Gly His1315 1320 1325His Arg Arg Arg Ala Pro Val Val Gln Pro Cys
Met Glu Ser Glu Asn1330 1335 1340Glu Asn Met Leu Ala Glu Tyr Glu
Gln Arg Gln Tyr Thr Ser Asp Cys1345 1350 1355 1360Cys Asn Ser Ser
Arg Glu Gly Asp Thr Cys Ser Cys Ser Glu Gly Ser1365 1370 1375Cys
Leu Tyr Ala Glu Ala Gly Glu Pro Ala Pro Arg Gln Met Thr Ala1380
1385 1390Lys Asn Thr1395161381PRTDrosophila melanogaster 16Gly Glu
Asn Pro Arg Ile Ile Glu His Pro Met Asp Thr Thr Val Pro1 5 10 15Lys
Asn Asp Pro Phe Thr Phe Asn Cys Gln Ala Glu Gly Asn Pro Thr20 25
30Pro Thr Ile Gln Trp Phe Lys Asp Gly Arg Glu Leu Lys Thr Asp Thr35
40 45Gly Ser His Arg Ile Met Leu Pro Ala Gly Gly Leu Phe Phe Leu
Lys50 55 60Val Ile His Ser Arg Arg Glu Ser Asp Ala Gly Thr Tyr Trp
Cys Glu65 70 75 80Ala Lys Asn Glu Phe Gly Val Ala Arg Ser Arg Asn
Ala Thr Leu Gln85 90 95Val Ala Val Leu Arg Asp Glu Phe Arg Leu Glu
Pro Ala Asn Thr Arg100 105 110Val Ala Gln Gly Glu Val Ala Leu Met
Glu Cys Gly Ala Pro Arg Gly115 120 125Ser Pro Glu Pro Gln Ile Ser
Trp Arg Lys Asn Gly Gln Thr Leu Asn130 135 140Leu Val Gly Asn Lys
Arg Ile Arg Ile Val Asp Gly Gly Asn Leu Ala145 150 155 160Ile Gln
Glu Ala Arg Gln Ser Asp Asp Gly Arg Tyr Gln Cys Val Val165 170
175Lys Asn Val Val Gly Thr Arg Glu Ser Ala Thr Ala Phe Leu Lys
Val180 185 190His Val Arg Pro Phe Leu Ile Arg Gly Pro Gln Asn Gln
Thr Ala Val195 200 205Val Gly Ser Ser Val Val Phe Gln Cys Arg Ile
Gly Gly Asp Pro Leu210 215 220Pro Asp Val Leu Trp Arg Arg Thr Ala
Ser Gly Gly Asn Met Pro Leu225 230 235 240Arg Lys Phe Ser Trp Leu
His Ser Ala Ser Gly Arg Val His Val Leu245 250 255Glu Asp Arg Ser
Leu Lys Leu Asp Asp Val Thr Leu Glu Asp Met Gly260 265 270Glu Tyr
Thr Cys Glu Ala Asp Asn Ala Val Gly Gly Ile Thr Ala Thr275 280
285Gly Ile Leu Thr Val His Ala Pro Pro Lys Phe Val Ile Arg Pro
Lys290 295 300Asn Gln Leu Val Glu Ile Gly Asp Glu Val Leu Phe Glu
Cys Gln Ala305 310 315 320Asn Gly His Pro Arg Pro Thr Leu Tyr Trp
Ser Val Glu Gly Asn Ser325 330 335Ser Leu Leu Leu Pro Gly Tyr Arg
Asp Gly Arg Met Glu Val Thr Leu340 345 350Thr Pro Glu Gly Arg Ser
Val Leu Ser Ile Ala Arg Phe Ala Arg Glu355 360 365Asp Ser Gly Lys
Val Val Thr Cys Asn Ala Leu Asn Ala Val Gly Ser370 375 380Val Ser
Ser Arg Thr Val Val Ser Val Asp Thr Gln Phe Glu Leu Pro385 390 395
400Pro Pro Ile Ile Glu Gln Gly Pro Val Asn Gln Thr Leu Pro Val
Lys405 410 415Ser Ile Val Val Leu Pro Cys Arg Thr Leu Gly Thr Pro
Val Pro Gln420 425 430Val Ser Trp Tyr Leu Asp Gly Ile Pro Ile Asp
Val Gln Glu His Glu435 440 445Arg Arg Asn Leu Ser Asp Ala Gly Ala
Leu Thr Ile Ser Asp Leu Gln450 455 460Arg His Glu Asp Glu Gly Leu
Tyr Thr Cys Val Ala Ser Asn Arg Asn465 470 475 480Gly Lys Ser Ser
Trp Ser Gly Tyr Leu Arg Leu Asp Thr Pro Thr Asn485 490 495Pro Asn
Ile Lys Phe Phe Arg Ala Pro Glu Leu Ser Thr Tyr Pro Gly500 505
510Pro Pro Gly Lys Pro Gln Met Val Glu Lys Gly Glu Asn Ser Val
Thr515 520 525Leu Ser Trp Thr Arg Ser Asn Lys Val Gly Gly Ser Ser
Leu Val Gly530 535 540Tyr Val Ile Glu Met Phe Gly Lys Asn Glu Thr
Asp Gly Trp Val Ala545 550 555 560Val Gly Thr Arg Val Gln Asn Thr
Thr Phe Thr Gln Thr Gly Leu Leu565 570 575Pro Gly Val Asn Tyr Phe
Phe Leu Ile Arg Ala Glu Asn Ser His Gly580 585 590Leu Ser Leu Pro
Ser Pro Met Ser Glu Pro Ile Thr Val Gly Thr Arg595 600 605Tyr Phe
Asn Ser Gly Leu Asp Leu Ser Glu Ala Arg Ala Ser Leu Leu610 615
620Ser Gly Asp Val Val Glu Leu Ser Asn Ala Ser Val Val Asp Ser
Thr625 630 635 640Ser Met Lys Leu Thr Trp Gln Ile Ile Asn Gly Lys
Tyr Val Glu Gly645 650 655Phe Tyr Val Tyr Ala Arg Gln Leu Pro Asn
Pro Ile Val Asn Asn Pro660 665 670Ala Pro Val Thr Ser Asn Thr Asn
Pro Leu Leu Gly Ser Thr Ser Thr675 680 685Ser Ala Ser Ala Ser Ala
Ser Ala Ser Ala Leu Ile Ser Thr Lys Pro690 695 700Asn Ile Ala Ala
Ala Gly Lys Arg Asp Gly Glu Thr Asn Gln Ser Gly705 710 715 720Gly
Gly Ala Pro Thr Pro Leu Asn Thr Lys Tyr Arg Met Leu Thr Ile725 730
735Leu Asn Gly Gly Gly Ala Ser Ser Cys Thr Ile Thr Gly Leu Val
Gln740 745 750Tyr Thr Leu Tyr Glu Phe Phe Ile Val Pro Phe Tyr Lys
Ser Val Glu755 760 765Gly Lys Pro Ser Asn Ser Arg Ile Ala Arg Thr
Leu Glu Asp Val Pro770 775 780Ser Glu Ala Pro Tyr Gly Met Glu Ala
Leu Leu Leu Asn Ser Ser Ala785 790 795 800Val Phe Leu Lys Trp Lys
Ala Pro Glu Leu Lys Asp Arg His Gly Val805 810 815Leu Leu Asn Tyr
His Val Ile Val Arg Gly Ile Asp Thr Ala His Asn820 825 830Phe Ser
Arg Ile Leu Thr Asn Val Thr Ile Asp Ala Ala Ser Pro Thr835 840
845Leu Val Leu Ala Asn Leu Thr Glu Gly Val Met Tyr Thr Val Gly
Val850 855 860Ala Ala Gly Asn Asn Ala Gly Val Gly Pro Tyr Cys Val
Pro Ala Thr865 870 875 880Leu Arg Leu Asp Pro Ile Thr Lys Arg Leu
Asp Pro Phe Ile Asn Gln885 890 895Arg Asp His Val Asn Asp Val Leu
Thr Gln Pro Trp Phe Ile Ile Leu900 905 910Leu Gly Ala Ile Leu Ala
Val Leu Met Leu Ser Phe Gly Ala Met Val915 920 925Phe Val Lys Arg
Lys His Met Met Met Lys Gln Ser Ala Leu Asn Thr930 935 940Met Arg
Gly Asn His Thr Ser Asp Val Leu Lys Met Pro Ser Leu Ser945 950 955
960Ala Arg Asn Gly Asn Gly Tyr Trp Leu Asp Ser Ser Thr Gly Gly
Met965 970 975Val Trp Arg Pro Ser Pro Gly Gly Asp Ser Leu Glu Met
Gln Lys Asp980 985 990His Ile Ala Asp Tyr Ala Pro Val Cys Gly Ala
Pro Gly Ser Pro Ala995 1000 1005Gly Gly Gly Thr Ser Ser Gly Gly Ser
Gly Gly Ala Gly Ser Gly Ala1010 1015 1020Ser Gly Gly Asp Asp Ile
His Gly Gly His Gly Ser Glu Arg Asn Gln1025 1030 1035 1040Gln Arg
Tyr Val Gly Glu Tyr Ser Asn Ile Pro Thr Asp Tyr Ala Glu1045 1050
1055Val Ser Ser Phe Gly Lys Ala Pro Ser Glu Tyr Gly Arg His Gly
Asn1060 1065 1070Ala Ser Pro Ala Pro Tyr Ala Thr Ser Ser Ile Leu
Ser Pro His Gln1075 1080 1085Gln Gln Gln Gln Gln Gln Pro Arg Tyr
Gln Gln Arg Pro Val Pro Gly1090 1095 1100Tyr Gly Leu Gln Arg Pro
Met His Pro His Tyr Gln Gln Gln Gln His1105 1110 1115 1120Gln Gln
Gln Gln Ala Gln Gln Thr His Gln Gln His Gln Ala Leu Gln1125 1130
1135Gln His Gln Gln Leu Pro Pro Ser Asn Ile Tyr Gln Gln Met Ser
Thr1140 1145 1150Thr Ser Glu Ile Tyr Pro Thr Asn Thr Gly Pro Ser
Arg Ser Val Tyr1155 1160 1165Ser Glu Gln Tyr Tyr Tyr Pro Lys Asp
Lys Gln Arg His Ile His Ile1170 1175 1180Thr Glu Asn Lys Leu Ser
Asn Cys His Thr Tyr Glu Ala Ala Pro Gly1185 1190 1195 1200Ala Lys
Gln Ser Ser Pro Ile Ser Ser Gln Phe Ala Ser Val Arg Arg1205 1210
1215Gln Gln Leu Pro Pro Asn Cys Ser Ile Gly Arg Glu Ser Ala Arg
Phe1220 1225 1230Lys Val Leu Asn Thr Asp Gln Gly Lys Asn Gln Gln
Asn Leu Leu Asp1235 1240 1245Leu Asp Gly Ser Ser Met Cys Tyr Asn
Gly Leu Ala Asp Ser Gly Cys1250 1255 1260Gly Gly Ser Pro Ser Pro
Met Ala Met Leu Met Ser His Glu Asp Glu1265 1270 1275 1280His Ala
Leu Tyr His Thr Ala Asp Gly Asp Leu Asp Asp Met Glu Arg1285 1290
1295Leu Tyr Val Lys Val Asp Glu Gln Gln Pro Pro Gln Gln Gln Gln
Gln1300 1305 1310Leu Ile Pro Leu Val Pro Gln His Pro Ala Glu Gly
His Leu Gln Ser1315 1320 1325Trp Arg Asn Gln Ser Thr Arg Ser Ser
Arg Lys Asn Gly Gln Glu Cys1330 1335 1340Ile Lys Glu Pro Ser Glu
Leu Ile Tyr Ala Pro Gly Ser Val Ala Ser1345 1350 1355 1360Glu Arg
Ser Leu Leu Ser Asn Ser Gly Ser Gly Thr Ser Ser Gln Pro1365 1370
1375Ala Gly His Asn Val1380171297PRTCaenorhabditis elegans 17Met
Tyr Tyr Leu Gly Phe Tyr His Thr His Thr His Thr His Thr Tyr1 5 10
15Ile Asn Phe Asp Lys Ile Pro Asn Ala Ser Asn Leu Ala Pro Val Ile20
25 30Ile Glu His Pro Ile Asp Val Val Val Ser Arg Gly Ser Pro Ala
Thr35 40 45Leu Asn Cys Gly Ala
Lys Pro Ser Thr Ala Lys Ile Thr Trp Tyr Lys50 55 60Asp Gly Gln Pro
Val Ile Thr Asn Lys Glu Gln Val Asn Ser His Arg65 70 75 80Ile Val
Leu Asp Thr Gly Ser Leu Phe Leu Leu Lys Val Asn Ser Gly85 90 95Lys
Asn Gly Lys Asp Ser Asp Ala Gly Ala Tyr Tyr Cys Val Ala Ser100 105
110Asn Glu His Gly Glu Val Lys Ser Asn Glu Gly Ser Leu Lys Leu
Ala115 120 125Met Leu Arg Glu Asp Phe Arg Val Arg Pro Arg Thr Val
Gln Ala Leu130 135 140Gly Gly Glu Met Ala Val Leu Glu Cys Ser Pro
Pro Arg Gly Phe Pro145 150 155 160Glu Pro Val Val Ser Trp Arg Lys
Asp Asp Lys Glu Leu Arg Ile Gln165 170 175Asp Met Pro Arg Tyr Thr
Leu His Ser Asp Gly Asn Leu Ile Ile Asp180 185 190Pro Val Asp Arg
Ser Asp Ser Gly Thr Tyr Gln Cys Val Ala Asn Asn195 200 205Met Val
Gly Glu Arg Val Ser Asn Pro Ala Arg Leu Ser Val Phe Glu210 215
220Lys Pro Lys Phe Glu Gln Glu Pro Lys Asp Met Thr Val Asp Val
Gly225 230 235 240Ala Ala Val Leu Phe Asp Cys Arg Val Thr Gly Asp
Pro Gln Pro Gln245 250 255Ile Thr Trp Lys Arg Lys Asn Glu Pro Met
Pro Val Thr Arg Ala Tyr260 265 270Ile Ala Lys Asp Asn Arg Gly Leu
Arg Ile Glu Arg Val Gln Pro Ser275 280 285Asp Glu Gly Glu Tyr Val
Cys Tyr Ala Arg Asn Pro Ala Gly Thr Leu290 295 300Glu Ala Ser Ala
His Leu Arg Val Gln Ala Pro Pro Ser Phe Gln Thr305 310 315 320Lys
Pro Ala Asp Gln Ser Val Pro Ala Gly Gly Thr Ala Thr Phe Glu325 330
335Cys Thr Leu Val Gly Gln Pro Ser Pro Ala Tyr Phe Trp Ser Lys
Glu340 345 350Gly Gln Gln Asp Leu Leu Phe Pro Ser Tyr Val Ser Ala
Asp Gly Arg355 360 365Thr Lys Val Ser Pro Thr Gly Thr Leu Thr Ile
Glu Glu Val Arg Gln370 375 380Val Asp Glu Gly Ala Tyr Val Cys Ala
Gly Met Asn Ser Ala Gly Ser385 390 395 400Ser Leu Ser Lys Ala Ala
Leu Lys Ala Thr Phe Glu Thr Lys Gly Arg405 410 415Val Gln Lys Lys
Lys Ser Lys Met Gly Lys Gln Lys Gln Lys Asn Val420 425 430Gln Ser
Ile Ile Lys Tyr Leu Ile Ser Ala Val Thr Gly Asn Thr Pro435 440
445Ala Lys Pro Pro Pro Thr Ile Glu His Gly His Gln Asn Gln Thr
Leu450 455 460Met Val Gly Ser Ser Ala Ile Leu Pro Cys Gln Ala Ser
Gly Lys Pro465 470 475 480Thr Pro Gly Ile Ser Trp Leu Arg Asp Gly
Leu Pro Ile Asp Ile Thr485 490 495Asp Ser Arg Ile Ser Gln His Ser
Thr Gly Ser Leu His Ile Ala Asp500 505 510Leu Lys Lys Pro Asp Thr
Gly Val Tyr Thr Cys Ile Ala Lys Asn Glu515 520 525Asp Gly Glu Ser
Thr Trp Ser Ala Ser Leu Thr Val Glu Asp His Thr530 535 540Ser Asn
Ala Gln Phe Val Arg Met Pro Asp Pro Ser Asn Phe Pro Ser545 550 555
560Ser Pro Thr Gln Pro Ile Ile Val Asn Val Thr Asp Thr Glu Val
Glu565 570 575Leu His Trp Asn Ala Pro Ser Thr Ser Gly Ala Gly Pro
Ile Thr Gly580 585 590Tyr Ile Ile Gln Tyr Tyr Ser Pro Asp Leu Gly
Gln Thr Trp Phe Asn595 600 605Ile Pro Asp Tyr Val Ala Ser Thr Glu
Tyr Arg Ile Lys Gly Leu Lys610 615 620Pro Ser His Ser Tyr Met Phe
Val Ile Arg Ala Glu Asn Glu Lys Gly625 630 635 640Ile Gly Thr Pro
Ser Val Ser Ser Ala Leu Val Thr Thr Ser Lys Pro645 650 655Ala Ala
Gln Val Ala Leu Ser Asp Lys Asn Lys Met Asp Met Ala Ile660 665
670Ala Glu Lys Arg Leu Thr Ser Glu Gln Leu Ile Lys Leu Glu Glu
Val675 680 685Lys Thr Ile Asn Ser Thr Ala Val Arg Leu Phe Trp Lys
Lys Arg Lys690 695 700Leu Glu Glu Leu Ile Asp Gly Tyr Tyr Ile Lys
Trp Arg Gly Pro Pro705 710 715 720Arg Thr Asn Asp Asn Gln Tyr Val
Asn Val Thr Ser Pro Ser Thr Glu725 730 735Asn Tyr Val Val Ser Asn
Leu Met Pro Phe Thr Asn Tyr Glu Phe Phe740 745 750Val Ile Pro Tyr
His Ser Gly Val His Ser Ile His Gly Ala Pro Ser755 760 765Asn Ser
Met Asp Val Leu Thr Ala Glu Ala Pro Pro Ser Leu Pro Pro770 775
780Glu Asp Val Arg Ile Arg Met Leu Asn Leu Thr Thr Leu Arg Ile
Ser785 790 795 800Trp Lys Ala Pro Lys Ala Asp Gly Ile Asn Gly Ile
Leu Lys Gly Phe805 810 815Gln Ile Val Ile Val Gly Gln Ala Pro Asn
Asn Asn Arg Asn Ile Thr820 825 830Thr Asn Glu Arg Ala Ala Ser Val
Thr Leu Phe His Leu Val Thr Gly835 840 845Met Thr Tyr Lys Ile Arg
Val Ala Ala Arg Ser Asn Gly Gly Val Gly850 855 860Val Ser His Gly
Thr Ser Glu Val Ile Met Asn Gln Asp Thr Leu Glu865 870 875 880Lys
His Leu Ala Ala Gln Gln Glu Asn Glu Ser Phe Leu Tyr Gly Leu885 890
895Ile Asn Lys Ser His Val Pro Val Ile Val Ile Val Ala Ile Leu
Ile900 905 910Ile Phe Val Val Ile Ile Ile Ala Tyr Cys Tyr Trp Arg
Asn Ser Arg915 920 925Asn Ser Asp Gly Lys Asp Arg Ser Phe Ile Lys
Ile Asn Asp Gly Ser930 935 940Val His Met Ala Ser Asn Asn Leu Trp
Asp Val Ala Gln Asn Pro Asn945 950 955 960Gln Asn Pro Met Tyr Asn
Thr Ala Gly Arg Met Thr Met Asn Asn Arg965 970 975Asn Gly Gln Ala
Leu Tyr Ser Leu Thr Pro Asn Ala Gln Asp Phe Phe980 985 990Asn Asn
Cys Asp Asp Tyr Ser Gly Thr Met His Arg Pro Gly Ser Glu995 1000
1005His His Tyr His Tyr Ala Gln Leu Thr Gly Gly Pro Gly Asn Ala
Met1010 1015 1020Ser Thr Phe Tyr Gly Asn Gln Tyr His Asp Asp Pro
Ser Pro Tyr Ala1025 1030 1035 1040Thr Thr Thr Leu Val Leu Ser Asn
Gln Gln Pro Ala Trp Leu Asn Asp1045 1050 1055Lys Met Leu Arg Ala
Pro Ala Met Pro Thr Asn Pro Val Pro Pro Glu1060 1065 1070Pro Pro
Ala Arg Tyr Ala Asp His Thr Ala Gly Arg Arg Ser Arg Ser1075 1080
1085Ser Arg Ala Ser Asp Gly Arg Gly Thr Leu Asn Gly Gly Leu His
His1090 1095 1100Arg Thr Ser Gly Ser Gln Arg Ser Asp Ser Pro Pro
His Thr Asp Val1105 1110 1115 1120Ser Tyr Val Gln Leu His Ser Ser
Asp Gly Thr Gly Ser Ser Lys Glu1125 1130 1135Arg Thr Gly Glu Arg
Arg Thr Pro Pro Asn Lys Thr Leu Met Asp Phe1140 1145 1150Ile Pro
Pro Pro Pro Ser Asn Pro Pro Pro Pro Gly Gly His Val Tyr1155 1160
1165Asp Thr Ala Thr Arg Arg Gln Leu Asn Arg Gly Ser Thr Pro Arg
Glu1170 1175 1180Asp Thr Tyr Asp Ser Val Ser Asp Gly Ala Phe Ala
Arg Val Asp Val1185 1190 1195 1200Asn Ala Arg Pro Thr Ser Arg Asn
Arg Asn Leu Gly Gly Arg Pro Leu1205 1210 1215Lys Gly Lys Arg Asp
Asp Asp Ser Gln Arg Ser Ser Leu Met Met Asp1220 1225 1230Asp Asp
Gly Gly Ser Ser Glu Ala Asp Gly Glu Asn Ser Glu Gly Asp1235 1240
1245Val Pro Arg Gly Gly Val Arg Lys Ala Val Pro Arg Met Gly Ile
Ser1250 1255 1260Ala Ser Thr Leu Ala His Ser Cys Tyr Gly Thr Asn
Gly Thr Ala Gln1265 1270 1275 1280Arg Phe Arg Ser Ile Pro Arg Asn
Asn Gly Ile Val Thr Gln Glu Gln1285 1290 1295Thr181651PRThuman
18Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser1
5 10 15Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro
Glu20 25 30Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr
Ser Asp35 40 45Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Ser Arg Leu
Arg Gln Glu50 55 60Asp Phe Pro Pro Arg Ile Val Glu His Pro Ser Asp
Leu Ile Val Ser65 70 75 80Lys Gly Glu Pro Ala Thr Leu Asn Cys Lys
Ala Glu Gly Arg Pro Thr85 90 95Pro Thr Ile Glu Trp Tyr Lys Gly Gly
Glu Arg Val Glu Thr Asp Lys100 105 110Asp Asp Pro Arg Ser His Arg
Met Leu Leu Pro Ser Gly Ser Leu Phe115 120 125Phe Leu Arg Ile Val
His Gly Arg Lys Ser Arg Pro Asp Glu Gly Val130 135 140Tyr Val Cys
Val Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser His Asn145 150 155
160Ala Ser Leu Glu Val Ala Ile Leu Arg Asp Asp Phe Arg Gln Asn
Pro165 170 175Ser Asp Val Met Val Ala Val Gly Glu Pro Ala Val Met
Glu Cys Gln180 185 190Pro Pro Arg Gly His Pro Glu Pro Thr Ile Ser
Trp Lys Lys Asp Gly195 200 205Ser Pro Leu Asp Asp Lys Asp Glu Arg
Ile Thr Ile Arg Gly Gly Lys210 215 220Leu Met Ile Thr Tyr Thr Arg
Lys Ser Asp Ala Gly Lys Tyr Val Cys225 230 235 240Val Gly Thr Asn
Met Val Gly Glu Arg Glu Ser Glu Val Ala Glu Leu245 250 255Thr Val
Leu Glu Arg Pro Ser Phe Val Lys Arg Pro Ser Asn Leu Ala260 265
270Val Thr Val Asp Asp Ser Ala Glu Phe Lys Cys Glu Ala Arg Gly
Asp275 280 285Pro Val Pro Thr Val Arg Trp Arg Lys Asp Asp Gly Glu
Leu Pro Lys290 295 300Ser Arg Tyr Glu Ile Arg Asp Asp His Thr Leu
Lys Ile Arg Lys Val305 310 315 320Thr Ala Gly Asp Met Gly Ser Tyr
Thr Cys Val Ala Glu Asn Met Val325 330 335Gly Lys Ala Glu Ala Ser
Ala Thr Leu Thr Val Gln Glu Pro Pro His340 345 350Phe Val Val Lys
Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val355 360 365Thr Phe
Gln Cys Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp370 375
380Arg Arg Glu Gly Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro
Gln385 390 395 400Ser Ser Ser Arg Phe Ser Val Ser Gln Thr Gly Asp
Leu Thr Ile Thr405 410 415Asn Val Gln Arg Ser Asp Val Gly Tyr Tyr
Ile Cys Gln Thr Leu Asn420 425 430Val Ala Gly Ser Ile Ile Thr Lys
Ala Tyr Leu Glu Val Thr Asp Val435 440 445Ile Ala Asp Arg Pro Pro
Pro Val Ile Arg Gln Gly Pro Val Asn Gln450 455 460Thr Val Ala Val
Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly465 470 475 480Ser
Pro Val Pro Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser485 490
495Thr Gln Asp Ser Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln
Ile500 505 510Arg Tyr Ala Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys
Ile Ala Ser515 520 525Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr
Ile Glu Val Gln Glu530 535 540Phe Gly Val Pro Val Gln Pro Pro Arg
Pro Thr Asp Pro Asn Leu Ile545 550 555 560Pro Ser Ala Pro Ser Lys
Pro Glu Val Thr Asp Val Ser Arg Asn Thr565 570 575Val Thr Leu Ser
Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr580 585 590Ser Tyr
Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln595 600
605Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly
Leu610 615 620Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala
Asn Ala Tyr625 630 635 640Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp
Pro Val Lys Thr Gln Asp645 650 655Val Leu Pro Thr Ser Gln Gly Val
Asp His Lys Gln Val Gln Arg Glu660 665 670Leu Gly Asn Ala Val Leu
His Leu His Asn Pro Thr Val Leu Ser Ser675 680 685Ser Ser Ile Glu
Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile690 695 700Gln Gly
Tyr Lys Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu705 710 715
720Ser Asp Trp Leu Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser
Val725 730 735Val Ile Pro Asp Leu Arg Lys Gly Val Asn Tyr Glu Ile
Lys Ala Arg740 745 750Pro Phe Phe Asn Glu Phe Gln Gly Ala Asp Ser
Glu Ile Lys Phe Ala755 760 765Lys Thr Leu Glu Glu Ala Pro Ser Ala
Pro Pro Gln Gly Val Thr Val770 775 780Ser Lys Asn Asp Gly Asn Gly
Thr Ala Ile Leu Val Ser Trp Gln Pro785 790 795 800Pro Pro Glu Asp
Thr Gln Asn Gly Met Val Gln Glu Tyr Lys Val Trp805 810 815Cys Leu
Gly Asn Glu Thr Arg Tyr His Ile Asn Lys Thr Val Asp Gly820 825
830Ser Thr Phe Ser Val Val Ile Pro Phe Leu Val Pro Gly Ile Arg
Tyr835 840 845Ser Val Glu Val Ala Ala Ser Thr Gly Ala Gly Ser Gly
Val Lys Ser850 855 860Glu Pro Gln Phe Ile Gln Leu Asp Ala His Gly
Asn Pro Val Ser Pro865 870 875 880Glu Asp Gln Val Ser Leu Ala Gln
Gln Ile Ser Asp Val Val Lys Gln885 890 895Pro Ala Phe Ile Ala Gly
Ile Gly Ala Ala Cys Trp Ile Ile Leu Met900 905 910Val Phe Ser Ile
Trp Leu Tyr Arg His Arg Lys Lys Arg Asn Gly Leu915 920 925Thr Ser
Thr Tyr Ala Gly Ile Arg Lys Val Pro Ser Phe Thr Phe Thr930 935
940Pro Thr Val Thr Tyr Gln Arg Gly Gly Glu Ala Val Ser Ser Gly
Gly945 950 955 960Arg Pro Gly Leu Leu Asn Ile Ser Glu Pro Ala Ala
Gln Pro Trp Leu965 970 975Ala Asp Thr Trp Pro Asn Thr Gly Asn Asn
His Asn Asp Cys Ser Ile980 985 990Ser Cys Cys Thr Ala Gly Asn Gly
Asn Ser Asp Ser Asn Leu Thr Thr995 1000 1005Tyr Ser Arg Pro Ala Asp
Cys Ile Ala Asn Tyr Asn Asn Gln Leu Asp1010 1015 1020Asn Lys Gln
Thr Asn Leu Met Leu Pro Glu Ser Thr Val Tyr Gly Asp1025 1030 1035
1040Val Asp Leu Ser Asn Lys Ile Asn Glu Met Lys Thr Phe Asn Ser
Pro1045 1050 1055Asn Leu Lys Asp Gly Arg Phe Val Asn Pro Ser Gly
Gln Pro Thr Pro1060 1065 1070Tyr Ala Thr Thr Gln Leu Ile Gln Ser
Asn Leu Ser Asn Asn Met Asn1075 1080 1085Asn Gly Ser Gly Asp Ser
Gly Glu Lys His Trp Lys Pro Leu Gly Gln1090 1095 1100Gln Lys Gln
Glu Val Ala Pro Val Gln Tyr Asn Ile Val Glu Gln Asn1105 1110 1115
1120Lys Leu Asn Lys Asp Tyr Arg Ala Asn Asp Thr Val Pro Pro Thr
Ile1125 1130 1135Pro Tyr Asn Gln Ser Tyr Asp Gln Asn Thr Gly Gly
Ser Tyr Asn Ser1140 1145 1150Ser Asp Arg Gly Ser Ser Thr Ser Gly
Ser Gln Gly His Lys Lys Gly1155 1160 1165Ala Arg Thr Pro Lys Val
Pro Lys Gln Gly Gly Met Asn Trp Ala Asp1170 1175 1180Leu Leu Pro
Pro Pro Pro Ala His Pro Pro Pro His Ser Asn Ser Glu1185 1190 1195
1200Glu Tyr Asn Ile Ser Val Asp Glu Ser Tyr Asp Gln Glu Met Pro
Cys1205 1210 1215Pro Val Pro Pro Ala Arg Met Tyr Leu Gln Gln Asp
Glu Leu Glu Glu1220 1225 1230Glu Glu Asp Glu Arg Gly Pro Thr Pro
Pro Val Arg Gly Ala Ala Ser1235 1240 1245Ser Pro Ala Ala Val Ser
Tyr Ser His Gln Ser Thr Ala Thr Leu Thr1250 1255 1260Pro Ser Pro
Gln Glu Glu Leu Gln Pro Met Leu Gln Asp Cys Pro Glu1265 1270 1275
1280Glu Thr Gly His Met Gln His Gln Pro Asp Arg Arg Arg Gln Pro
Val1285 1290 1295Ser Pro Pro Pro Pro Pro Arg Pro Ile Ser Pro Pro
His Thr Tyr Gly1300 1305 1310Tyr Ile Ser Gly Pro Leu Val Ser Asp
Met Asp Thr Asp Ala Pro Glu1315 1320 1325Glu Glu Glu Asp Glu Ala
Asp Met Glu Val Ala Lys Met Gln Thr Arg1330 1335 1340Arg Leu Leu
Leu Arg Gly Leu Glu Gln Thr Pro Ala Ser Ser Val Gly1345 1350 1355
1360Asp Leu Glu Ser Ser Val Thr Gly Ser Met Ile Asn Gly Trp Gly
Ser1365 1370 1375Ala Ser Glu Glu Asp Asn Ile Ser Ser Gly Arg Ser
Ser Val Ser Ser1380 1385 1390Ser Asp Gly Ser Phe Phe Thr Asp Ala
Asp Phe Ala Gln Ala Val
Ala1395 1400 1405Ala Ala Ala Glu Tyr Ala Gly Leu Lys Val Ala Arg
Arg Gln Met Gln1410 1415 1420Asp Ala Ala Gly Arg Arg His Phe His
Ala Ser Gln Cys Pro Arg Pro1425 1430 1435 1440Thr Ser Pro Val Ser
Thr Asp Ser Asn Met Ser Ala Ala Val Met Gln1445 1450 1455Lys Thr
Arg Pro Ala Lys Lys Leu Lys His Gln Pro Gly His Leu Arg1460 1465
1470Arg Glu Thr Tyr Thr Asp Asp Leu Pro Pro Pro Pro Val Pro Pro
Pro1475 1480 1485Ala Ile Lys Ser Pro Thr Ala Gln Ser Lys Thr Gln
Leu Glu Val Arg1490 1495 1500Pro Val Val Val Pro Lys Leu Pro Ser
Met Asp Ala Arg Thr Asp Arg1505 1510 1515 1520Ser Ser Asp Arg Lys
Gly Ser Ser Tyr Lys Gly Arg Glu Val Leu Asp1525 1530 1535Gly Arg
Gln Val Val Asp Met Arg Thr Asn Pro Gly Asp Pro Arg Glu1540 1545
1550Ala Gln Glu Gln Gln Asn Asp Gly Lys Gly Arg Gly Asn Lys Ala
Ala1555 1560 1565Lys Arg Asp Leu Pro Pro Ala Lys Thr His Leu Ile
Gln Glu Asp Ile1570 1575 1580Leu Pro Tyr Cys Arg Pro Thr Phe Pro
Thr Ser Asn Asn Pro Arg Asp1585 1590 1595 1600Pro Ser Ser Ser Ser
Ser Met Ser Ser Arg Gly Ser Gly Ser Arg Gln1605 1610 1615Arg Glu
Gln Ala Asn Val Gly Arg Arg Asn Ile Ala Glu Met Gln Val1620 1625
1630Leu Gly Gly Tyr Glu Arg Gly Glu Asp Asn Asn Glu Glu Leu Glu
Glu1635 1640 1645Thr Glu
Ser165019434PRThumanmisc_feature(285)..(396)note="Xaa signifies gap
in sequence" 19Gln Ile Val Ala Gln Gly Arg Thr Val Thr Phe Pro Cys
Glu Thr Lys1 5 10 15Gly Asn Pro Gln Pro Ala Val Phe Trp Gln Lys Glu
Gly Ser Gln Asn20 25 30Leu Leu Phe Pro Asn Gln Pro Gln Gln Pro Asn
Ser Arg Cys Ser Val35 40 45Ser Pro Thr Gly Asp Leu Thr Ile Thr Asn
Ile Gln Arg Ser Asp Ala50 55 60Gly Tyr Tyr Ile Cys Gln Ala Leu Thr
Val Ala Gly Ser Ile Leu Ala65 70 75 80Lys Ala Gln Leu Glu Val Thr
Asp Val Leu Thr Asp Arg Pro Pro Pro85 90 95Ile Ile Leu Gln Gly Pro
Ala Asn Gln Thr Leu Ala Val Asp Gly Thr100 105 110Ala Leu Leu Lys
Cys Lys Ala Thr Gly Asp Pro Leu Pro Val Ile Ser115 120 125Trp Leu
Lys Glu Gly Phe Thr Phe Pro Gly Arg Asp Pro Arg Ala Thr130 135
140Ile Gln Glu Gln Gly Thr Leu Gln Ile Lys Asn Leu Arg Ile Ser
Asp145 150 155 160Thr Gly Thr Tyr Thr Cys Val Ala Thr Ser Ser Ser
Gly Glu Ala Ser165 170 175Trp Ser Ala Val Leu Asp Val Thr Glu Ser
Gly Ala Thr Ile Ser Lys180 185 190Asn Tyr Asp Leu Ser Asp Leu Pro
Gly Pro Pro Ser Lys Pro Gln Val195 200 205Thr Asp Val Thr Lys Asn
Ser Val Thr Leu Ser Trp Gln Pro Gly Thr210 215 220Pro Gly Thr Leu
Pro Ala Ser Ala Tyr Ile Ile Glu Ala Phe Ser Gln225 230 235 240Ser
Val Ser Asn Ser Trp Gln Thr Val Ala Asn His Val Lys Thr Thr245 250
255Leu Tyr Thr Val Arg Gly Leu Arg Pro Asn Thr Ile Tyr Leu Phe
Met260 265 270Val Arg Ala Ile Asn Pro Lys Val Ser Val Thr Gln Xaa
Lys Pro Gln275 280 285Lys Asn Asn Gly Ser Thr Trp Ala Asn Val Pro
Leu Pro Pro Pro Pro290 295 300Val Gln Pro Leu Pro Gly Thr Glu Leu
Glu His Tyr Ala Val Glu Gln305 310 315 320Gln Glu Asn Gly Tyr Asp
Ser Asp Ser Trp Cys Pro Pro Leu Pro Val325 330 335Gln Thr Tyr Leu
His Gln Gly Leu Glu Asp Glu Leu Glu Glu Asp Asp340 345 350Asp Arg
Val Pro Thr Pro Pro Val Arg Gly Val Ala Ser Ser Pro Ala355 360
365Ile Ser Phe Gly Gln Gln Ser Thr Ala Thr Leu Thr Pro Ser Pro
Arg370 375 380Glu Glu Met Gln Pro Met Leu Gln Ala Ser Pro Xaa Phe
Thr Ser Ser385 390 395 400Gln Arg Pro Arg Pro Thr Ser Pro Phe Ser
Thr Asp Ser Asn Thr Ser405 410 415Ala Ala Leu Ser Gln Ser Gln Arg
Pro Arg Pro Thr Lys Lys His Lys420 425 430Gly Gly20148PRTmouse
20Ala Gln Ala Val Ala Ala Ala Ala Glu Tyr Ala Gly Leu Lys Val Ala1
5 10 15Arg Arg Gln Met Gln Asp Ala Ala Gly Arg Arg His Phe His Ala
Ser20 25 30Gln Cys Pro Arg Pro Thr Ser Pro Val Ser Thr Asp Ser Asn
Met Ser35 40 45Ala Val Val Ile Gln Lys Ala Arg Pro Ala Lys Lys Gln
Lys His Gln50 55 60Pro Gly His Leu Arg Arg Glu Ala Tyr Ala Asp Asp
Leu Pro Pro Pro65 70 75 80Pro Val Pro Pro Pro Ala Ile Lys Ser Pro
Thr Val Gln Ser Lys Ala85 90 95Gln Leu Glu Val Arg Pro Val Met Val
Pro Lys Leu Ala Ser Ile Glu100 105 110Ala Arg Thr Asp Arg Ser Ser
Asp Arg Lys Gly Gly Ser Tyr Lys Gly115 120 125Arg Glu Ala Leu Asp
Gly Arg Gln Val Thr Asp Leu Arg Thr Asn Pro130 135 140Ser Asp Pro
Arg145
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