U.S. patent application number 11/831080 was filed with the patent office on 2009-02-05 for topical oral composition.
Invention is credited to Irwin E. Smigel.
Application Number | 20090035231 11/831080 |
Document ID | / |
Family ID | 40338358 |
Filed Date | 2009-02-05 |
United States Patent
Application |
20090035231 |
Kind Code |
A1 |
Smigel; Irwin E. |
February 5, 2009 |
TOPICAL ORAL COMPOSITION
Abstract
A topical oral composition in an orally acceptable carrier, the
composition comprising: dehydroacetic acid, a peroxide source and
optionally sodium lauryl sulfoacetate, gelling agents, flavors, and
abrasives.
Inventors: |
Smigel; Irwin E.; (New York,
NY) |
Correspondence
Address: |
MEREDITH & KEYHANI, PLLC
330 MADISON AVE., 6TH FLOOR
NEW YORK
NY
10017
US
|
Family ID: |
40338358 |
Appl. No.: |
11/831080 |
Filed: |
July 31, 2007 |
Current U.S.
Class: |
424/53 |
Current CPC
Class: |
A61K 8/466 20130101;
A61Q 11/00 20130101; A61K 8/36 20130101; A61K 8/22 20130101 |
Class at
Publication: |
424/53 |
International
Class: |
A61K 8/22 20060101
A61K008/22; A61Q 11/00 20060101 A61Q011/00 |
Claims
1. A topical oral composition in an orally acceptable carrier, said
composition comprising: dehydroacetic acid, sodium lauryl
sulfoacetate and a peroxide source.
2. A topical oral composition in an orally acceptable carrier as in
claim 1, further comprising a gelling agent.
3. A topical oral composition in an orally acceptable carrier as in
claim 1, further comprising flavors.
4. A topical oral composition in an orally acceptable carrier as in
claim 1, further comprising abrasives.
5. A topical oral composition in an orally acceptable carrier as in
claim 1, wherein said peroxide source is at least one peroxide
source selected from the group consisting of hydrogen peroxide,
urea hydrogen peroxide and calcium peroxide.
6. A topical oral composition in an orally acceptable carrier as in
claim 1, wherein said dehydroacetic acid is between 0.05 to 30.0
percent by weight.
7. A topical oral composition in an orally acceptable carrier as in
claim 6, wherein said dehydroacetic acid is between 0.1 and 1.0
percent by weight.
8. A topical oral composition in an orally acceptable carrier as in
claim 1, wherein said peroxide source is between 0.005 and 30
percent by weight.
9. A topical oral composition in an orally acceptable carrier as in
claim 1, wherein said sodium lauryl sulfoacetate is between 0.1 and
10.0 percent by weight.
10. A topical oral composition in an orally acceptable carrier as
in claim 1, wherein said sodium lauryl sulfoacetate is preferably
between 0.5 and 3.0 percent by weight.
11. A topical oral composition in an orally acceptable carrier as
in claim 1, wherein said topical oral composition has a pH between
3.0 and 9.0.
12. A topical oral composition in an orally acceptable carrier as
in claim 1, wherein said topical oral composition has a pH
preferably between 6.5 and 8.5.
13. A topical oral composition in an orally acceptable carrier as
in claim 1, further comprising malic acid.
14. A topical oral composition in an orally acceptable carrier as
in claim 1, wherein the Ratio of dehydroacetic acid to said
peroxide source is 0.05% to 1.00% of dehydroacetic acid to 0.01% to
1.00% of said peroxide source.
15. A topical oral composition in an orally acceptable carrier,
said composition comprising: sodium lauryl sulfoacetate, between
0.1 and 1.0 dehydroacetic acid, and at least two peroxide sources,
each of said peroxide sources selected from the group consisting of
hydrogen peroxide, urea hydrogen peroxide and calcium peroxide.
16. A topical oral composition in an orally acceptable carrier as
in claim 15, further comprising a gelling agent.
17. A topical oral composition in an orally acceptable carrier as
in claim 15, further comprising flavors.
18. A topical oral composition in an orally acceptable carrier as
in claim 15, further comprising abrasives.
19. A topical oral composition in an orally acceptable carrier as
in claim 15, wherein said peroxide source is between 0.005 and 30
percent by weight.
20. A topical oral composition in an orally acceptable carrier as
in claim 15, wherein said sodium lauryl sulfoacetate is between 0.1
and 10.0 percent by weight.
21. A topical oral composition in an orally acceptable carrier as
in claim 15, wherein said topical oral composition has a pH between
3.0 and 9.0.
22. A topical oral composition in an orally acceptable carrier as
in claim 15, wherein said topical oral composition has a pH
preferably between 6.5 and 8.5.
23. A topical oral composition in an orally acceptable carrier as
in claim 15, further comprising malic acid.
24. A topical oral composition in an orally acceptable carrier as
in claim 15, wherein the Ratio of dehydroacetic acid to said
peroxide source is 0.05% to 1.00% of dehydroacetic acid to 0.01% to
1.00% of said peroxide source.
Description
[0001] The present invention relates generally to topical oral
compositions, and in particular to germicidal oral
compositions.
[0002] The number of dental plaque micro-organisms use to colonize
the enamel tooth surface have been well characterized. The normal
oral cavity contains at least 300 different bacterial species. The
great majority of these are found in dental plaque. Organisms such
as oral streptococci sanguis and streptococcus parasanguis are
among the earliest plaque colonizing organisms. Also streptococcus
mutans is the major cause of dental caries due to both
sucrose-independent and sucrose-dependent mechanisms of
colonization and the ability to produce large amounts of lactic
acid responsible for demineralizing the enamel surface creating a
carious lesion. Lesions in turn will ease formation of stains on
the enamel of the teeth. Therefore, the inhibition of these three
species is critical in reducing dental plaque and caries and in
turn easing the removal of stains of variety in nature.
[0003] Accordingly, what is needed is a topical oral composition
that inhibits the colonization of bacterial species.
SUMMARY OF THE INVENTION
[0004] The present invention relates generally germicidal topical
oral compositions.
[0005] According to one embodiment of the present invention, a
topical oral composition in an orally acceptable carrier is
provided, the composition comprising: sodium lauryl sulfoacetate,
dehydroacetic, and a peroxide source
[0006] According to another embodiment of the present invention, a
topical oral composition in an orally acceptable carrier is
provided, the composition comprising: sodium lauryl sulfoacetate,
between 0.1 and 1.0 dehydroacetic acid, and a peroxide source
selected from the group consisting of hydrogen peroxide, urea
hydrogen peroxide and calcium peroxide.
[0007] These and other features, aspects and advantages of the
present invention will become better understood with reference to
the following description and claims.
DETAILED DESCRIPTION OF THE INVENTION
[0008] The following detailed description is of the best currently
contemplated modes of carrying out the invention. The description
is not to be taken in a limiting sense, but is made merely for the
purpose of illustrating the general principles of the invention,
since the scope of the invention is best defined by the appended
claims.
[0009] The term topical oral composition refers to a product which
in the ordinary course of usage is not intentionally swallowed, but
rather is retained in the oral cavity for a time sufficient to
contact dental surfaces and oral tissue. The term topical oral
composition is intended to include, by way of example, toothpaste
(gel or paste), tooth powder, denture gel, denture product,
mouthrinse, mouthspray, foam and dentrifice. According to the
present invention, a topical oral composition in an orally
acceptable carrier is provided, the composition comprising: sodium
lauryl sulfoacetate, dehydroacetic acid, and a peroxide source.
There may also be gelling agents, flavors and abrasives. By way of
example, gelling agents may be The peroxide source may be hydrogen
peroxide, urea hydrogen peroxide, calcium peroxide and any
combination thereof. It is desired that the dehydroacetic acid
ranges from 0.05 to 30.0 percent by weight and is preferably
between 0.1 and 1.0 percent by weight. The peroxide source may be
between 0.005 and 30 percent by weight. The Ratio of dehydroacetic
acid to the peroxide source may be 0.05% to 1.00% of dehydroacetic
acid to 0.01% to 1.00% of the peroxide source. The sodium lauryl
sulfoacetate may be between 0.1 and 10.0 percent by weight. The ph
of the topical oral composition may be between 3.0 and 9.0 and
preferably between 6.5 and 8.5. The composition may be further
comprised of malic acid.
TABLE-US-00001 TABLE 1 EXAMPLE EXAMPLE EXAMPLE COMPONENT 1 II III
Deionized water 21.34% 63.79% 76.72% Sorbitol (70%) 20% 8% 5%
Glycerine (99.7%) 20% 8% 5% Urea Hydrogen Peroxide 3% 1.5% 1%
Calcium Peroxide 2.5% 1.25% 0.8% Sodium Perborate 1.3% 1.15% 0.4%
Sodium Bicarbonate 10% 5% 3.33% Tetra Sodium Pyrophosphate 3% 1.5%
1% Corn Starch 1% 0.5% 0.3% Sodium Saccharin 0.5% 0.25% 0.2% Methyl
Paraben 0.5% 0.25% 0.2% Propyl Paraben 0.1% 0.05% 0.03% Sodium Mono
0.76% 0.76% 0.76% Fluorophosphate Dehydroacetic Acid 1% 0.5% 0.33%
Malic Acid 5% 2.5% 1.7% Cellulose Gum 2% 1% 0.6% Titanium Dioxide
4% 2% 1.3% Sodium Lauryl Sulfoacetate 3% 1.5% 1% Flavor 1% 0.5%
0.33%
[0010] Table 1 provides examples according to the present
invention. As shown, according to one example Example 1: deionized
water is 21.34 percent by weight, sorbitol (70%) is 20% by weight,
glycerine (99.7%) is 20 percent by weight, urea hydrogen peroxide
is three (3) percent by weight, calcium peroxide is 2.5 percent by
weight, sodium perborate is 1.3 percent by weight, sodium
bicarbonate is 10 percent by weight, tetra sodium pyrophosphate is
3 percent by weight, corn starch is 1 percent by weight, sodium
saccharin is 0.5 percent by weight, methyl paraben is 0.5 percent
by weight, propyl paraben is 0.1 percent by weight, sodium mono
fluorophosphate is 0.76 percent by weight, dehydroacetic acid is 1
percent by weight, malic acid is 5 percent by weight, cellulose gum
is 2 percent by weight, titanium dioxide is 4 percent by weight,
sodium lauryl sulfoacetate is three percent by weight, and flavor
is one percent by weight.
[0011] According to the present invention and as shown in Table 1,
is Example 2. Example 2: deionized water is 63.79 percent by
weight, sorbitol (70%) is 8% by weight, glycerine (99.7%) is 8
percent by weight, urea hydrogen peroxide is 1.5 percent by weight,
calcium peroxide is 1.25 percent by weight, sodium perborate is
1.15 percent by weight, sodium bicarbonate is 5 percent by weight,
tetra sodium pyrophosphate is 1.5 percent by weight, corn starch is
0.5 percent by weight, sodium saccharin is 0.25 percent by weight,
methyl paraben is 0.25 percent by weight, propyl paraben is 0.05
percent by weight, sodium mono fluorophosphate is 0.76 percent by
weight, dehydroacetic acid is 0.5 percent by weight, malic acid is
2.5 percent by weight, cellulose gum is 1 percent by weight,
titanium dioxide is 2 percent by weight, sodium lauryl sulfoacetate
is 1.5 percent by weight, and flavor is 0.5 percent by weight.
[0012] Another example, according to the present invention and as
shown in Table 1, is Example 3. Example 3: deionized water is 76.72
percent by weight, sorbitol (70%) is 5% by weight, glycerine
(99.7%) is 5 percent by weight, urea hydrogen peroxide is 1 percent
by weight, calcium peroxide is 0.8 percent by weight, sodium
perborate is 0.4 percent by weight, sodium bicarbonate is 3.33
percent by weight, tetra sodium pyrophosphate is 1 percent by
weight, corn starch is 0.3 percent by weight, sodium saccharin is
0.2 percent by weight, methyl paraben is 0.2 percent by weight,
propyl paraben is 0.03 percent by weight, sodium mono
fluorophosphate is 0.76 percent by weight, dehydroacetic acid is
0.33 percent by weight, malic acid is 1.7 percent by weight,
cellulose gum is 0.6 percent by weight, titanium dioxide is 1.3
percent by weight, sodium lauryl sulfoacetate is 1 percent by
weight, and flavor is 0.33 percent by weight.
[0013] It should be understood that the foregoing relates to
preferred embodiments of the invention and that modifications may
be made without departing from the spirit and scope of the
invention as set forth in the following claims.
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