U.S. patent application number 12/175361 was filed with the patent office on 2008-12-18 for quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus proliferator receptor, and medicinal composition containing the same.
This patent application is currently assigned to KIRIN BEER KABUSHIKI KAISHA. Invention is credited to Yasunari Fujiwara, Atsushi Miwa, Kazuhide Nakamura, Tsuyoshi Nishitoba, Tatsushi Osawa, Terufumi Senga.
Application Number | 20080312221 12/175361 |
Document ID | / |
Family ID | 19029043 |
Filed Date | 2008-12-18 |
United States Patent
Application |
20080312221 |
Kind Code |
A1 |
Fujiwara; Yasunari ; et
al. |
December 18, 2008 |
QUINOLINE DERIVATIVE AND QUINAZOLINE DERIVATIVE INHIBITING
SELF-PHOSPHORYLATION OF HEPATOCYTUS PROLIFERATOR RECEPTOR, AND
MEDICINAL COMPOSITION CONTAINING THE SAME
Abstract
An objective of the present invention is to provide compounds
having potent antitumor activity. The compounds of the present
invention are represented by formula (I) or a pharmaceutically
acceptable salt or solvate thereof: ##STR00001## wherein X=CH or N;
Z=O or S; L=O or S; M=CR.sup.10R.sup.11, wherein R.sup.10 and
R.sup.11=H, alkyl, or alkoxy, NR.sup.12 wherein R.sup.12=H or
alkyl; R.sup.1, R.sup.2, and R.sup.3=H or optionally substituted
alkoxy; R.sup.4=H; R.sup.5-8=H, halogen, alkoxy or the like; and
R.sup.9=alkyl optionally substituted by --R.sup.14, -T-R.sup.15, or
--NR.sup.16R.sup.17 wherein T=O, S, or NH; R.sup.14=an optionally
substituted carbocyclic or heterocyclic ring; and R.sup.15-17=alkyl
or an optionally substituted carbocyclic or heterocyclic ring, or
--NR.sup.18R.sup.19 wherein R.sup.18 and R.sup.19=H, optionally
substituted alkyl, or an optionally substituted carbocylic or
heterocyclic ring, or optionally substituted carbocyclic or
heterocyclic ring.
Inventors: |
Fujiwara; Yasunari;
(Tokyo-To, JP) ; Senga; Terufumi; (Takasaki-shi,
JP) ; Nishitoba; Tsuyoshi; (Tokyo-To, JP) ;
Osawa; Tatsushi; (Takasaki-shi, JP) ; Miwa;
Atsushi; (Takasaki-shi, JP) ; Nakamura; Kazuhide;
(Takasaki-shi, JP) |
Correspondence
Address: |
OBLON, SPIVAK, MCCLELLAND MAIER & NEUSTADT, P.C.
1940 DUKE STREET
ALEXANDRIA
VA
22314
US
|
Assignee: |
KIRIN BEER KABUSHIKI KAISHA
Tokyo-To
JP
|
Family ID: |
19029043 |
Appl. No.: |
12/175361 |
Filed: |
July 17, 2008 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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10480632 |
Jun 17, 2004 |
7425564 |
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PCT/JP02/06239 |
Jun 21, 2002 |
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12175361 |
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Current U.S.
Class: |
514/228.2 ;
514/235.2; 514/312; 544/128; 544/62; 546/153 |
Current CPC
Class: |
C07D 405/12 20130101;
A61P 43/00 20180101; A61K 31/47 20130101; A61P 35/00 20180101; C07D
409/12 20130101; C07D 215/40 20130101; A61K 31/517 20130101; C07D
413/12 20130101; A61K 31/4709 20130101; A61K 31/496 20130101; C07D
239/88 20130101; C07D 401/12 20130101; A61K 31/5377 20130101; C07D
215/233 20130101 |
Class at
Publication: |
514/228.2 ;
546/153; 544/128; 544/62; 514/312; 514/235.2 |
International
Class: |
A61K 31/47 20060101
A61K031/47; C07D 215/233 20060101 C07D215/233; C07D 413/12 20060101
C07D413/12; A61K 31/541 20060101 A61K031/541; A61P 35/00 20060101
A61P035/00; A61K 31/5377 20060101 A61K031/5377; C07D 417/12
20060101 C07D417/12 |
Foreign Application Data
Date |
Code |
Application Number |
Jun 22, 2001 |
JP |
2001-190238 |
Claims
1: A method for treating a malignant tumor, comprising the step of
administering a therapeutically effective amount of at least one
compound represented by formula (I) or a pharmaceutically
acceptable salt or solvate thereof to a mammal: ##STR01173##
wherein X represents CH or N; Z represents O or S; L represents O
or S; M represents --C(--R.sup.10)(--R.sup.11)-- wherein R.sup.10
and R.sup.11, which may be the same or different, represent a
hydrogen atom, C.sub.1-4 alkyl, or C.sub.1-4 alkoxy, or
--N(--R.sup.12)-- wherein R.sup.12 represents a hydrogen atom or
C.sub.1-4 alkyl; R.sup.1, R.sup.2, and R.sup.3, which may be the
same or different, represent a hydrogen atom, hydroxyl, a halogen
atom, nitro, amino, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6
alkynyl, or C.sub.1-6 alkoxy, in which one or two hydrogen atoms on
the amino group are optionally substituted by C.sub.1-6 alkyl which
is optionally substituted by hydroxyl or C.sub.1-6 alkoxy, and in
which the C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl,
and C.sub.1-6 alkoxy groups are optionally substituted by hydroxyl;
a halogen atom; C.sub.1-6 alkoxy; C.sub.1-6 alkylcarbonyl;
C.sub.1-6 alkoxy carbonyl; amino on which one or two hydrogen atoms
is optionally substituted by C.sub.1-6 alkyl which is optionally
substituted by hydroxyl or C.sub.1-6 alkoxy; or a saturated or
unsaturated three- to eight-membered carbocyclic or heterocyclic
group which is optionally substituted by C.sub.1-6 alkyl which is
optionally substituted by hydroxyl or C.sub.1-6 alkoxy; R.sup.4
represents a hydrogen atom; R.sup.5, R.sup.6, R.sup.7, and R.sup.8,
which may be the same or different, represent a hydrogen atom, a
halogen atom, C.sub.1-4 alkyl, or C.sub.1-4 alkoxy; R.sup.9
represents C.sub.1-6 alkyl on which one or more hydrogen atoms are
optionally substituted by --R.sup.14, -T-R.sup.15, or
--NR.sup.16R.sup.17 wherein T represents --O--, --S--, or --NH--;
R.sup.14 represents a saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; R.sup.15,
R.sup.16, and R.sup.17, which may be the same or different,
represent C.sub.1-6 alkyl or a saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; the three- to
eight-membered carbocyclic or heterocyclic group represented by
R.sup.14, R.sup.15, R.sup.16, and R.sup.17 is optionally
substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom,
nitro, trifluoromethyl, C.sub.1-6 alkoxy carbonyl, cyano, cyano
C.sub.1-6 alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a
saturated or unsaturated five- or six-membered heterocyclic ring;
when the three- to eight-membered carbocyclic or heterocyclic group
is substituted by two C.sub.1-6 alkyl groups, the two alkyl groups
may combine together to form an alkylene chain; and the three- to
eight-membered carbocyclic or heterocyclic group may be a bicyclic
group condensed with another saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group,
--N(--R.sup.18)(--R.sup.19) wherein R.sup.18 and R.sup.19, which
may be the same or different, represent a hydrogen atom; C.sub.1-6
alkyl which is optionally substituted by C.sub.1-6 alkoxy,
C.sub.1-6 alkylthio, or a saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group in which the
three- to eight-membered carbocyclic or heterocyclic group is
optionally substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a
halogen atom, nitro, trifluoromethyl, C.sub.1-6 alkoxy carbonyl,
cyano, cyano C.sub.1-6 alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl,
or a saturated or unsaturated five- or six-membered heterocyclic
ring and, when the three- to eight-membered carbocyclic or
heterocyclic group is substituted by two C.sub.1-6 alkyl groups,
the two alkyl groups may combine together to form an alkylene
chain, or the three- to eight-membered carbocyclic or heterocyclic
group may be a bicyclic group condensed with another saturated or
unsaturated three- to eight-membered carbocyclic or heterocyclic
group; or a saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group which is optionally substituted
by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom, nitro,
trifluoromethyl, C.sub.1-6 alkoxy carbonyl, cyano, cyano C.sub.1-6
alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a saturated or
unsaturated five- or six-membered heterocyclic ring and in which,
when the three- to eight-membered carbocyclic or heterocyclic group
is substituted by two C.sub.1-6 alkyl groups, the two alkyl groups
may combine together to form an alkylene chain, or the three- to
eight-membered carbocyclic or heterocyclic group may be a bicyclic
group condensed with another saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group, or a saturated or
unsaturated three- to eight-membered carbocyclic or heterocyclic
group which is optionally substituted by C.sub.1-6 alkyl, C.sub.1-6
alkoxy, a halogen atom, nitro, trifluoromethyl, C.sub.1-6 alkoxy
carbonyl, cyano, cyano C.sub.1-6 alkyl, C.sub.1-6 alkylthio,
phenoxy, acetyl, or a saturated or unsaturated five- or
six-membered heterocyclic ring and in which, when the three- to
eight-membered carbocyclic or heterocyclic group is substituted by
two C.sub.1-6 alkyl groups, the two alkyl groups may combine
together to form an alkylene chain, or the three- to eight-membered
carbocyclic or heterocyclic group may be a bicyclic group condensed
with another saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group, provided that, when X represents
CH; Z represents O; L represents an oxygen atom; M represents
--NH--; R.sup.1, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8
represent a hydrogen atom; and R.sup.2 and R.sup.3 represent
methoxy, R.sup.9 does not represent phenyl, ethoxy, or
pyridin-2-yl.
2: The method according to claim 1, wherein R.sup.1 and R.sup.4
represent a hydrogen atom and R.sup.2 and R.sup.3 represent a group
other than a hydrogen atom.
3: The method according to claim 1 or 2, wherein all of R.sup.5,
R.sup.6, R.sup.7, and R.sup.8 represent a hydrogen atom, or any one
or two of R.sup.5, R.sup.6, R.sup.7, and R.sup.8 represent a group
other than a hydrogen atom with all the remaining groups
representing a hydrogen atom.
4: The method according to any one of claims 1 to 3, wherein the
optionally substituted alkyl group represented by R.sup.9
represents --(CH.sub.2)p-R.sup.14, --(CH.sub.2)p-T-R.sup.15, or
--(CH.sub.2)p-NR.sup.16R.sup.17 wherein p is an integer of 1 to 6
and R.sup.14, R.sup.15, R.sup.16, and R.sup.17 are as defined in
claim 1.
5: The method according to any one of claims 1 to 3, wherein
R.sup.18 represents a hydrogen atom or C.sub.1-6 alkyl; R.sup.19
represents C.sub.1-6 alkyl which is optionally substituted by an
optionally substituted saturated or unsaturated five- or
six-membered carbocyclic or heterocyclic group; or an optionally
substituted saturated or unsaturated five- or six-membered
carbocyclic or heterocyclic group.
6: The method according to any one of claims 1 to 6, wherein X
represents CH or N, Z represents O, L represents O, M represents
--N(--R.sup.12)--, R.sup.1 and R.sup.4 represent a hydrogen atom,
R.sup.2 represents unsubstituted C.sub.1-6 alkoxy, R.sup.3
represents optionally substituted C.sub.1-6 alkoxy, and all of
R.sup.5, R.sup.6, R.sup.7, and R.sup.8 represent a hydrogen atom,
or any one of R.sup.5, R.sup.6, R.sup.7, and R.sup.8 represents a
group other than a hydrogen atom with all the remaining groups
representing a hydrogen atom.
7: The method according to any one of claims 1 to 6, wherein X
represents CH or N, Z represents O, L represents O, M represents
--C(--R.sup.10) (--R.sup.11)--, R.sup.1 and R.sup.4 represent a
hydrogen atom, R.sup.2 represents unsubstituted C.sub.1-6 alkoxy
group, R.sup.3 represents optionally substituted C.sub.1-6 alkoxy,
and all of R.sup.5, R.sup.6, R.sup.7, and R.sup.8 represent a
hydrogen atom, or any one of R.sup.5, R.sup.6, R.sup.7, and R.sup.8
represents a group other than a hydrogen atom with all the
remaining groups representing a hydrogen atom.
8: The method according to any one of claims 1 to 6, wherein X
represents CH or N, Z represents O, L represents S, M represents
--N(--R.sup.12)--, R.sup.1 and R.sup.4 represent a hydrogen atom,
R.sup.2 represent unsubstituted C.sub.1-6 alkoxy, R.sup.3
represents optionally substituted C.sub.1-6 alkoxy, and all of
R.sup.5, R.sup.6, R.sup.7, and R.sup.8 represent a hydrogen atom,
or any one of R.sup.5, R.sup.6, R.sup.7, and R.sup.8 represents a
group other than a hydrogen atom with all the remaining groups
representing a hydrogen atom.
9: The method according to claim 1, wherein the compound is
represented by formula (100): ##STR01174## wherein R.sup.103
represents hydroxyl or C.sub.1-4 alkoxy which is optionally
substituted by a halogen atom; hydroxyl; amino on which one or two
hydrogen atoms are optionally substituted by C.sub.1-6 alkyl which
is optionally substituted by hydroxyl or C.sub.1-6 alkoxy; or a
saturated or unsaturated five- to seven-membered carbocyclic or
heterocyclic group which is optionally substituted by C.sub.1-6
alkyl which is optionally substituted by hydroxyl or C.sub.1-6
alkoxy, R.sup.105, R.sup.106, R.sup.107, and R.sup.108, which may
be the same or different, represents a hydrogen atom, a halogen
atom, C.sub.1-4 alkyl, or C.sub.1-4 alkoxy, and R.sup.109
represents C.sub.1-6 alkyl on which one or more hydrogen atoms are
optionally substituted by --R.sup.114, -T-R.sup.115, or
--NR.sup.116R.sup.117 in which T represents --O--, --S--, or
--NH--; R.sup.114 represents saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; R.sup.115
represents C.sub.1-6 alkyl or a saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; R.sup.116 and
R.sup.117, which may be the same or different, represent C.sub.1-6
alkyl or a saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group; the three- to eight-membered
carbocyclic or heterocyclic group represented by R.sup.114,
R.sup.115, R.sup.116, and R.sup.117 is optionally substituted by
C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom, nitro,
trifluoromethyl, C.sub.1-6 alkoxy carbonyl, cyano, cyano C.sub.1-6
alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a saturated or
unsaturated five- or six-membered heterocyclic ring; when the
three- to eight-membered carbocyclic or heterocyclic group is
substituted by two C.sub.1-6 alkyl groups, the two alkyl groups may
combine together to form an alkylene chain, or the three- to
eight-membered carbocyclic or heterocyclic group may be a bicyclic
group condensed with another saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group or a saturated or
unsaturated three- to eight-membered carbocyclic or heterocyclic
group which is optionally substituted by C.sub.1-6 alkyl, C.sub.1-6
alkoxy, a halogen atom, nitro, trifluoromethyl, C.sub.1-6
alkoxycarbonyl, cyano, cyano C.sub.1-6 alkyl, C.sub.1-6 alkylthio,
phenoxy, acetyl, or a saturated or unsaturated five- or
six-membered heterocyclic ring; when the three- to eight-membered
carbocyclic or heterocyclic group is substituted by two C.sub.1-6
alkyl groups, the two alkyl groups may combine together to form an
alkylene chain; and the three- to eight-membered carbocyclic or
heterocyclic group may be a bicyclic group condensed with another
saturated or unsaturated three- to eight-carbocyclic or
heterocyclic group.
10: The method according to claim 9, wherein the optionally
substituted alkyl group represented by R.sup.109 represents
--(CH.sub.2)p-R.sup.114, --(CH.sub.2)p-T-R.sup.115, or
--(CH.sub.2)p-NR.sup.116R.sup.117 in which p is an integer of 1 to
6, R.sup.114, R.sup.115, R.sup.116, and R.sup.117 are as defined in
claim 9.
11: The method according to claim 1, wherein the compound is
represented by formula (200): ##STR01175## wherein R.sup.203
represents hydroxyl or C.sub.1-4 alkoxy which is optionally
substituted by a halogen atom; hydroxyl; amino on which one or two
hydrogen atoms are optionally substituted by C.sub.1-6 alkyl which
is optionally substituted by hydroxyl or C.sub.1-6 alkoxy; or a
saturated or unsaturated five- to seven-membered carbocyclic or
heterocyclic group which is optionally substituted by C.sub.1-6
alkyl which is optionally substituted by hydroxyl or C.sub.1-6
alkoxy, R.sup.205, R.sup.206, R.sup.207, and R.sup.208, which may
be the same or different, represent a hydrogen atom, a halogen
atom, C.sub.1-4 alkyl, or C.sub.1-4 alkoxy, and R.sup.209
represents C.sub.1-6 alkyl on which one or more hydrogen atoms are
optionally substituted by --R.sup.214, -T-R.sup.215, or
--NR.sup.216R.sup.217 wherein T represents --O--, --S--, or --NH--;
R.sup.214 represents a saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; R.sup.215
represents C.sub.1-6 alkyl or a saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; R.sup.216 and
R.sup.217, which may be the same or different, represent C.sub.1-6
alkyl or a saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group; the three- to eight-membered
carbocyclic or heterocyclic group represented by R.sup.214,
R.sup.215, R.sup.216, and R.sup.217 is optionally substituted by
C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom, nitro,
trifluoromethyl, C.sub.1-6 alkoxy carbonyl, cyano, cyano C.sub.1-6
alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a saturated or
unsaturated five- or six-membered heterocyclic ring; when the
three- to eight-membered carbocyclic or heterocyclic group is
substituted by two C.sub.1-6 alkyl groups, the two alkyl groups may
combine together to form an alkylene chain; and the three- to
eight-membered carbocyclic or heterocyclic group may be a bicyclic
group condensed with another saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group, or a saturated or
unsaturated three- to eight-membered carbocyclic or heterocyclic
group which is optionally substituted by C.sub.1-6 alkyl, C.sub.1-6
alkoxy, a halogen atom, nitro, trifluoromethyl, C.sub.1-6 alkoxy
carbonyl, cyano, cyano C.sub.1-6 alkyl, C.sub.1-6 alkylthio,
phenoxy, acetyl, or a saturated or unsaturated five- or
six-membered heterocyclic ring; when the three- to eight-membered
carbocyclic or heterocyclic group is substituted by two C.sub.1-6
alkyl groups, the two alkyl groups may combine together to form an
alkylene chain; and the three- to eight-membered carbocyclic or
heterocyclic group may be a bicyclic group condensed with another
saturated or unsaturated three- to eight-membered carbocyclic or
heterocyclic group.
12: The method according to claim 11, wherein the optionally
substituted alkyl group represented by R.sup.209 represents
--(CH.sub.2)p-R.sup.214, --(CH.sub.2)p-T-R.sup.215, or
--(CH.sub.2)p-NR.sup.216R.sup.217 in which p is an integer of 1 to
6, R.sup.214, R.sup.215, R.sup.216, and R.sup.217 are as defined in
claim 1.
13: The method according to claim 1, wherein the compound is
represented by formula (300): ##STR01176## wherein R.sup.303
represents hydroxyl or C.sub.1-4 alkoxy which is optionally
substituted by a halogen atom or a saturated or unsaturated
six-membered carbocyclic or heterocyclic group which is optionally
substituted by C.sub.1-6 alkyl which is optionally substituted by
hydroxyl or C.sub.1-6 alkoxy, R.sup.305, R.sup.306, R.sup.307, and
R.sup.308, which may be the same or different, represent a hydrogen
atom, a halogen atom, C.sub.1-4 alkyl, or C.sub.1-4 alkoxy,
R.sup.310 and R.sup.311 represent a hydrogen atom, C.sub.1-4 alkyl,
or C.sub.1-4 alkoxy, R.sup.318 represents a hydrogen atom or
C.sub.1-4 alkyl, R.sup.319 represents C.sub.1-4 alkyl which is
optionally substituted by a saturated or unsaturated six-membered
carbocyclic group which is optionally substituted by C.sub.1-6
alkyl; C.sub.1-6 alkoxy; a halogen atom; nitro; trifluoromethyl;
C.sub.1-6 alkoxy carbonyl; cyano; cyano C.sub.1-6 alkyl; C.sub.1-6
alkylthio; phenoxy; acetyl; or a saturated or unsaturated five- or
six-membered heterocyclic ring and in which, when substituted by
two C.sub.1-6 alkyl groups, the two alkyl groups may combine
together to form an alkylene chain, or may be a bicyclic group
condensed with another saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group, or a saturated or
unsaturated four- to seven-membered carbocyclic or heterocyclic
group which is optionally substituted by C.sub.1-6 alkyl, C.sub.1-6
alkoxy, a halogen atom, nitro, trifluoromethyl, C.sub.1-6 alkoxy
carbonyl, cyano, cyano C.sub.1-6 alkyl, C.sub.1-6 alkylthio,
phenoxy, acetyl, or a saturated or unsaturated five- or
six-membered heterocyclic ring; when the four- to seven-membered
carbocyclic or heterocyclic group is substituted by two C.sub.1-6
alkyl groups, the two alkyl groups may combine together to form an
alkylene chain; and the four- to seven-membered carbocyclic or
heterocyclic group may be a bicyclic group condensed with another
saturated or unsaturated three- to eight-membered carbocyclic or
heterocyclic group.
14: The method according to claim 1, wherein the compound is
represented by formula (400): ##STR01177## wherein R.sup.405,
R.sup.406, R.sup.407, and R.sup.408, which may be the same or
different, represent a hydrogen atom, a halogen atom, C.sub.1-4
alkyl, or C.sub.1-4 alkoxy, R.sup.419 represents an unsaturated
five- or six-membered carbocyclic or heterocyclic group which is
optionally substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a
halogen atom, nitro, trifluoromethyl, C.sub.1-6 alkoxy carbonyl,
cyano, cyano C.sub.1-6 alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl,
or a saturated or unsaturated five- or six-membered heterocyclic
ring; when the five- or six-membered carbocyclic or heterocyclic
group is substituted by two C.sub.1-6 alkyl groups, the two alkyl
groups may combine together to form an alkylene chain; and the
five- or six-membered carbocyclic or heterocyclic group may be a
bicyclic group condensed with another saturated or unsaturated
three- to eight-membered carbocyclic or heterocyclic group.
15: The method according to claim 1, wherein the compound is
represented by formula (500): ##STR01178## wherein X represents CH
or N, when L represents O and M represents --N(--R.sup.12)--, Q
represents CH.sub.2 or NH, when L represents O and M represents
--C(--R.sup.10)(--R.sup.11)--, Q represents NH, when L represents S
and M represents --N(--R.sup.12)--, Q represents CH.sub.2,
R.sup.503 represents hydroxyl or C.sub.1-4 alkoxy which is
optionally substituted by a halogen atom; hydroxyl; amino on which
one or two hydrogen atoms are optionally substituted by C.sub.1-6
alkyl which is optionally substituted by hydroxyl or C.sub.1-6
alkoxy; or a saturated or unsaturated five- to seven-membered
carbocyclic or heterocyclic group which is optionally substituted
by C.sub.1-6 alkyl which is optionally substituted by hydroxyl or
C.sub.1-6 alkoxy, R.sup.505, R.sup.506, R.sup.507, and R.sup.508,
which may be the same or different, represent a hydrogen atom, a
halogen atom, C.sub.1-4 alkyl, or C.sub.1-4 alkoxy, and R.sup.520
represents a saturated or unsaturated five- or six-membered
carbocyclic or heterocyclic group which is optionally substituted
by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, or a halogen atom.
16: The method according to claim 1, wherein said at least one
compound is selected from the group consisting of: (1)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-N'-phenylacetylthio-
urea; (2)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-N'-[2-(4-f-
luorophenyl)acetyl]thiourea; (3)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-N'-[2-(4-fluorophen-
yl)acetyl]urea; (4)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-phenyl-acetylurea;
(5)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(4-fluorophenyl)malonamide-
; (6)
N-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-N'-(2,4-difluo-
rophenyl)malonamide; (7)
1-(2-cyclopentylsulfanylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)pheny-
l]urea; (8)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-[2-(2,3-dihydro-1-
H-1-indol-1-yl)acetyl]-urea; (9)
N-phenyl-({[4-(6,7-dimethoxyquinolin-4-yloxy)-anilino]carbonyl}amino)meth-
anamide; (10)
N-(4-fluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; (11)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-3-phenylacetylurea; (12)
1-(3-fluoro-4-{6-methoxy-7-[4-(4-methyl-piperazin-1-yl)-butoxy]quinolin-4-
-yloxy}phenyl)-3-phenylacetylurea; (13)
1-{3-fluoro-4-[6-methoxy-7-(2-piperidin-1-yl-ethoxy)quinolin-4-yloxy]phen-
yl}-3-phenylacetylurea; (14)
1-{4-[7-(3-chloro-propoxy)-6-methoxyquinolin-4-yloxy]-3-fluorophenyl}-3-p-
henylacetylurea; (15)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]-2-me-
thylmalonamide; (16)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-phenylacetylurea;
(17)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-phenylacetyl-
urea; (18)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-phenyla-
cetylurea; (19)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-(2-thiophen-3-yla-
cetyl)urea; (20)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-(2-thiophen-3-yla-
cetyl)urea; (21)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-(2-thiophen-3-yla-
cetyl)urea; (22)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(4-fluorophenyl)acetyl]u-
rea; (23)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-[2-(4-fl-
uorophenyl)acetyl]urea; (24)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(4-fluorophenyl-
)acetyl]urea; (25)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-fluorophenyl)acetyl]u-
rea; (26)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-[2-(2-fl-
uorophenyl)acetyl]urea; (27)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(2-fluorophenyl-
)acetyl]urea; (28)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-[2-(2-fluoropheny-
l)acetyl]urea; (29)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-thiophen-2-ylacetyl)urea-
; (30)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-(2-thiophen-
-2-ylacetyl)urea; (31)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-(2-thiophen-2-yla-
cetyl)urea; (32)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-(2-thiophen-2-yla-
cetyl)urea; (33)
1-[2-(2,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]urea; (34)
1-[2-(2,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; (35)
1-[2-(3,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; (36)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-[2-(3-fluoropheny-
l)acetyl]urea; (37)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-[2-(3-fluoropheny-
l)acetyl]urea; (38)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-methoxyphenyl]-3-[2-(4-fluoropheny-
l)acetyl]urea; (39)
1-[2-(3,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phen-
yl]urea; (40)
1-[4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(4-fluo-
rophenyl)acetyl]urea; (41)
1-{3-fluoro-4-[6-methoxy-7-(4-morpholin-4-yl-butoxy)quinolin-4-yloxy]phen-
yl}-3-[2-(4-fluorophenyl)-acetyl]urea; (42)
1-{3-fluoro-4-[6-methoxy-7-(4-piperidine-1-yl-butoxy)quinolin-4-yloxy]phe-
nyl}-3-[2-(4-fluorophenyl)-acetyl]urea; (43)
1-(3-fluoro-4-{6-methoxy-7-[4-(4-methyl-piperazin-1-yl)-butoxy]quinolin-4-
-yloxy}phenyl)-3-[2-(4-fluorophenyl)acetyl]urea; (44)
1-{2-fluoro-4-[6-methoxy-7-(4-morpholin-4-yl-butoxy)quinolin-4-yloxy]phen-
yl}-3-[2-(4-fluorophenyl)-acetyl]urea; (45)
1-{2-fluoro-4-[6-methoxy-7-(4-piperidine-1-yl-butoxy)quinolin-4-yloxy]phe-
nyl}-3-[2-(4-fluorophenyl)-acetyl]urea; (46)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-3-[2-(4-fluorophenyl)-acetyl]urea; (47)
1-{3-fluoro-4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-3-[2-(4-fluorophenyl)-acetyl]urea; (48)
1-{3-fluoro-4-[6-methoxy-7-(2-piperidin-1-yl-ethoxy)quinolin-4-yloxy]phen-
yl}-3-[2-(4-fluorophenyl)-acetyl]urea; (49)
1-(3-fluoro-4-{6-methoxy-7-[2-(4-methyl-piperazin-1-yl)-ethoxy]quinolin-4-
-yloxy}phenyl)-3-[2-(4-fluorophenyl)acetyl]urea; (50)
1-{2-fluoro-4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-3-[2-(4-fluorophenyl)-acetyl]urea; (51)
1-(2-fluoro-4-{6-methoxy-7-[3-(4-methyl-piperazin-1-yl)-propoxy]quinolin--
4-yloxy}phenyl)-3-[2-(4-fluorophenyl)acetyl]urea; (52)
1-{3-fluoro-4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-3-phenylacetylurea; (53)
1-(3-fluoro-4-{6-methoxy-7-[3-(4-methyl-piperazin-1-yl)-propoxy]quinolin--
4-yloxy}phenyl)-3-phenylacetylurea; (54)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)quinolin-4-yloxy]phen-
yl}-3-phenylacetylurea; (55)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)quinolin-4-yloxy]phen-
yl}-3-[2-(4-fluorophenyl)-acetyl]urea; (56)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(naphthalene-1-carbonyl)thi-
ourea; (57)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-(naphthalene-1-ca-
rbonyl)thiourea; (58)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-phenylacetylthiour-
ea; (59)
1-[2-(2-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
phenyl]thiourea; (60)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-phenylacetylthiourea;
(61)
1-(2-cyclohexylacetyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]thiour-
ea; (62)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(3-ethoxypropionyl)-
thiourea; (63)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-phenylacetylthiou-
rea; (64)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-(3-o-tol-
ylpropionyl)thiourea; (65)
1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-phenylacetylthiou-
rea; (66)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-thiophen-2-ylac-
etyl)thiourea; (67)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-methyl-phenyl]-3-phenylacetylthiou-
rea; (68)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-methoxyphenyl]-3-phenylac-
etylthiourea; (69)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-methoxyphenyl]-3-phenylacetylthiou-
rea; (70)
1-[3,5-dichloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-pheny-
lacetylthiourea; (71)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(4-fluorophenyl)acetyl]t-
hiourea; (72)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-[2-(4-fluoropheny-
l)acetyl]thiourea; (73)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-[2-(4-fluoropheny-
l)acetyl]thiourea; (74)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-[2-(3-fluoropheny-
l)acetyl]thiourea; (75)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-[2-(3-fluoropheny-
l)acetyl]thiourea; (76)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-[2-(3-fluoropheny-
l)acetyl]thiourea; (77)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-m-tolylacetyl)thiourea;
(78)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-(2-m-tolylac-
etyl)thiourea; (79)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-o-tolylacetyl)thiourea;
(80)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-[2-(2-fluoro-
phenyl)acetyl]thiourea; (81)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-[2-(2-fluoropheny-
l)acetyl]thiourea; (82)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-(2-p-tolylacetyl)-
thiourea; (83)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-[2-(2-methoxyphen-
yl)acetyl]thiourea; (84)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(2-O--
tolylacetyl)thiourea; (85)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-(2-thiophen-3-yla-
cetyl)thiourea; (86)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-methoxyphenyl]-3-(2-thiophen-3-yla-
cetyl)thiourea; (87)
1-[2-(2-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluor-
ophenyl]thiourea; (88)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
phenyl]thiourea; (89)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
phenyl]thiourea; (90)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
-3-fluorophenyl]thiourea; (91)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[3-chloro-4-(6,7-dimethoxyquinolin-
-4-yloxy)phenyl]thiourea; (92)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-(2-p-tolylacetyl)-
thiourea; (93)
1-[2-(2,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; (94)
1-[2-(2,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; (95)
1-[2-(2,6-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; (96)
1-[2-(2,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; (97)
1-[2-(2,6-dichlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; (98)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluorophe-
nyl]malonamide; (99)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluorophe-
nyl]malonamide; (100)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-phenylmalonamide;
(101)
N-cycloheptyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]malonamide;
(102)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl-
]malonamide; (103)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]-2-me-
thoxymalonamide; (104)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]-2,2--
dimethylmalonamide; (105)
N-(4-methyl-2-pyridyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; (106)
1-[3-fluoro-4-(7-hydroxy-6-methoxyquinolin-4-yloxy)phenyl]-3-phenylacetyl-
urea; (107)
1-(2-chloro-benzoyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluorophenyl-
]urea; (108)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-(2-methyl-benzoyl)-
urea; (109)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-pentanoylurea;
(110)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-diethylam-
inoacetyl)urea; (111)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-pyrrolidin-1-yl
acetyl)urea; (112)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(isopropylmethy-
lamino)acetyl]urea; (113)
1-(2-cyclohexylsulfanylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl-
]urea; (114)
1-(2-cyclohexylsulfanylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-flu-
orophenyl]urea; (115)
1-(2-cyclohexylsulfanylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-flu-
orophenyl]urea; (116)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-cyclopentylsulf-
anylacetyl)urea; (117)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-o-tolylaminoacetyl)urea;
(118)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-thiophen-3-ylacety-
l)urea; (119)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(6-methyl-3,4-d-
ihydro-2H-quinolin-1-yl)acetyl]urea; (120)
1-[2-(4-benzyl-piperidin-1-yl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy-
)-3-fluorophenyl]urea; (121)
1-[2-(2,3-dihydro-1H-1-indol-1-yl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-y-
loxy)-2-fluorophenyl]urea; (122)
1-[2-(2,3-dihydro-1H-1-indol-1-yl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-y-
loxy)-3-fluorophenyl]urea; (123)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-[1,2,3]triazol--
1-ylacetyl)urea; (124)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-(2-p-tolylacetyl)u-
rea; (125)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinoli-
n-4-yloxy)phenyl]urea; (126)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
-2-fluorophenyl]urea; (127)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
-3-fluorophenyl]urea; (128)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[3-chloro-4-(6,7-dimethoxyquinolin-
-4-yloxy)phenyl]urea; (129)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-phenylsulfanylacetyl)ure-
a; (130)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(1-meth-
yl-1H-imidazol-2-ylsulfanyl)-acetyl]urea; (131)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-thiomorpholin-4-
-ylacetyl)urea; (132)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-thiomorpholin-4-
-ylacetyl)urea; (133)
1-[2-(2,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; (134)
1-[2-(2,6-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]urea; (135)
1-[2-(2,6-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; (136)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(2-trifluoromet-
hylphenyl)acetyl]urea; (137)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(2-trifluoromet-
hylphenyl)acetyl]urea; (138)
1-[2-(2,3-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]urea; (139)
1-[2-(2,3-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; (140)
1-[2-(3,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]urea; (141)
1-[2-(3,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]urea; (142)
1-[2-(3,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; (143)
1-cyclopentanecarbonyl-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluorophen-
yl]thiourea; (144)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(3-methoxybenzoyl)-
thiourea; (145)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(3-trifluoromethyl-benzoyl)-
thiourea; (146)
1-(2-bromobenzoyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluorophenyl]t-
hiourea; (147)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(3-methylsulfanylp-
ropionyl)thiourea; (148)
1-(4-chloro-butyryl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluorophenyl-
]thiourea; (149)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-O--
tolylacetyl)thiourea; (150)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-phenylcyclopropanecarbon-
yl)thiourea; (151)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-fluorophenyl)acetyl]t-
hiourea; (152)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-fluorophenyl-
)acetyl]thiourea; (153)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-methoxyphenyl)acetyl]-
thiourea; (154)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-methoxyphenyl)acetyl]-
thiourea; (155)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-nitrophenyl)acetyl]th-
iourea; (156)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-nitrophenyl)-
acetyl]thiourea; (157)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-phenoxyacetyl)t-
hiourea; (158)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-phenylpropionyl)thiourea-
; (159)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(3-ethoxypr-
opionyl)thiourea; (160)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(5-methylthiophen-2-carbony-
l)thiourea; (161)
1-(3-cyclopentylpropionyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]thi-
ourea; (162)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-methylphenyl]-3-phenylacetylthiour-
ea; (163)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2,5-dimethylphenyl]-3-pheny-
lacetylthiourea; (164)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(3-fluorophenyl)acetyl]t-
hiourea; (165)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(3-ethoxypropionyl-
)thiourea; (166)
1-(2-cyclohexylacetyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluorophen-
yl]thiourea; (167)
1-(2-butoxyacetyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluorophenyl]t-
hiourea; (168)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-p-tolylacetyl)thiourea;
(169)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(2-methox-
yphenyl)acetyl]thiourea; (170)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-(2-O--
tolylacetyl)thiourea; (171)
1-[2-(3-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]t-
hiourea; (172)
1-[2-(3-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluor-
ophenyl]thiourea; (173)
1-[2-(3-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluor-
ophenyl]thiourea; (174)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(3-chlorophenyl-
)acetyl]thiourea; (175)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-(2-m-tolylacetyl)t-
hiourea; (176)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(2-m-tolylacetyl)t-
hiourea; (177)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(5-methyl-hexanoyl)thiourea-
; (178)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-(5-methyl-h-
exanoyl)thiourea; (179)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(5-methyl-hexanoyl-
)thiourea; (180)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(3-methoxy-propion-
yl)thiourea; (181)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(3-methoxypheny-
l)acetyl]thiourea; (182)
1-[2-(2-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluor-
ophenyl]thiourea; (183)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-chlorophenyl-
)acetyl]thiourea; (184)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(3-methoxyphenyl)acetyl]-
thiourea; (185)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(3-methoxypheny-
l)acetyl]thiourea; (186)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(3-methoxypheny-
l)acetyl]thiourea; (187)
1-[2-(4-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]t-
hiourea; (188)
1-[2-(4-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluor-
ophenyl]thiourea; (189)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(4-chlorophenyl-
)acetyl]thiourea; (190)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(2-p-tolylacetyl)t-
hiourea; (191)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(4-methyl-cyclo-
hexyl)acetyl]thiourea; (192)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(4-methyl-cyclo-
hexyl)acetyl]thiourea; (193)
1-(2-butoxyacetyl)-3-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]th-
iourea; (194)
1-[2-(2,3-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; (195)
1-[2-(2,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; (196)
1-[2-(3,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; (197)
1-[2-(3,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; (198)
1-[2-(3,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; (199)
1-[2-(3,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; (200)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(2-trifluoromet-
hylphenyl)acetyl]-thiourea; (201)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(2-trifluoromet-
hylphenyl)acetyl]-thiourea; (202)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(3-trifluoromet-
hylphenyl)acetyl]-thiourea; (203)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(3-trifluoromet-
hylphenyl)acetyl]-thiourea; (204)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2,3,6-trifluorophenyl)a-
cetyl]thiourea; (205)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(2,3,6-trifluor-
ophenyl)acetyl]-thiourea; (206)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(2,3,6-trifluor-
ophenyl)acetyl]-thiourea; (207)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2,3,6-trifluor-
ophenyl)acetyl]-thiourea; (208)
1-[2-(2,6-dichlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; (209)
N-butyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]malonamide;
(210)
N-(3-chlorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]malonamid-
e; (211)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(2-methoxyphenyl)m-
alonamide; (212)
N-cyclobutyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]malonamide;
(213) methyl
3-{2-[4-(6,7-dimethoxyquinolin-4-yloxy)phenylcarbamoyl]acetylamino}benzoa-
te; (214)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(1-phenylethyl)ma-
lonamide; (215)
N-benzyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]malonamide;
(216)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-methyl-N'-phenylmalonamide-
; (217)
N-cyclohexyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]malonamid-
e; (218)
N-cyclohexylmethyl-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]m-
alonamide; (219)
N-(4-chlorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]malonamid-
e; (220)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(3-hydroxyphenyl)m-
alonamide; (221)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(3,3-dimethyl-butyl)malona-
mide; (222)
N-[2-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(2,4-difluorophen-
yl)malonamide; (223)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-methylphe-
nyl]malonamide; (224)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2,5-dimethy-
lphenyl]malonamide; (225)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-2-methyl-N'-phenylmalonamide;
(226)
N-cyclohexyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-2-methylm-
alonamide; (227)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-pyridin-3-ylmalonamide;
(228)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-2,2-dimethyl-N'-phenylm-
alonamide; (229)
N-(2,4-difluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; (230)
N-(3-bromo-5-methyl-2-pyridyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilin-
o]carbonyl}amino)-methanamide; (231)
N-(5-chloro-2-pyridyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; (232)
N-(5-methyl-3-isoxazolyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]car-
bonyl}amino)-methanamide; (233)
N-(3-methyl-2-pyridyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; (234)
N-(6-methyl-2-pyridyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; (235)
N-(5-methyl-2-pyridyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; (236)
N-(2-pyridyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]carbonyl}amino)-
methanamide; (237)
N-(1-methyl-1H-5-pyrazolyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]c-
arbonyl}amino)-methanamide; (238)
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)-
anilino]carbonyl}amino)-methanamide; (239)
N-(3-cyanophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}a-
mino)-methanamide; (240)
N-[2-(trifluoromethyl)phenyl]-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino-
]carbonyl}amino)methan-amide; (241)
N-[4-(cyanomethyl)phenyl]-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]car-
bonyl}amino)-methanamide; (242)
N-(4-chloro-2-methylphenyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]c-
arbonyl}amino)-methanamide; (243)
N-(2,3-dihydro-1H-5-indenyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]-
carbonyl}amino)-methanamide; (244)
N-(3-methoxyphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl-
}amino)methanamide; (245) methyl
2-({({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]carbonyl}amino)carbonyl}a-
mino)benzoate; (246)
N-(2-benzylphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; (247)
N-(2-bromophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}a-
mino)methanamide; (248)
N-(2-chlorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; (249)
N-(4-chlorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; (250)
N-(2-chloro-4-fluorophenyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]c-
arbonyl}amino)-methanamide; (251)
N-(3-fluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; (252)
N-(2-fluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; (253)
N-[2-(methylsulfanyl)phenyl]-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]-
carbonyl}amino)-methanamide; (254)
N-(4-nitrophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}a-
mino)methanamide; (255)
N-(2-phenoxyphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl-
}amino)methanamide; (256)
N-(3-methylphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; (257)
N-(4-methylphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; (258)
N-(2,6-dimethylphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; (259)
N-[2-(1H-1-pyrrolyl)phenyl]-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]c-
arbonyl}amino)-methanamide; (260)
N-(8-quinolyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]carbonyl}amino-
)methanamide; (261)
N-(3-acetylphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)-methanamide; (262)
N-(5-quinolyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]carbonyl}amino-
)methanamide; (263)
N-(2,6-dichlorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; (264)
N-(3,4-difluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; (265)
N-(2,6-difluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; (266)
N-(2-methoxyphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl-
}amino)methanamide; (267)
N-[2-(2-hydroxyethyl)phenyl]-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]-
carbonyl}amino)-methanamide; (268)
N-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-N'-phenylacetyl-thiourea; (269)
N-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-N'-(4-fluorophenyl)-malonamide; (270)
1-(3-fluoro-4-{6-methoxy-7-[2-(4-methyl-piperazin-1-yl)-ethoxy]-quinolin--
4-yloxy}-phenyl)-3-phenylacetyl-thiourea; (271)
1-(3-fluoro-4-{6-methoxy-7-[2-(4-methyl-piperazin-1-yl)-ethoxy]-quinolin--
4-yloxy}-phenyl)-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; (272)
1-{4-[7-(2-diethylamino-ethoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phen-
yl}-3-phenylacetylthio-urea; (273)
1-(3-fluoro-4-{6-methoxy-7-[2-(4-methyl-[1,4]diazepan-1-yl)-ethoxy]-quino-
lin-4-yloxy}-phenyl)-3-phenylacetyl-thiourea; (275)
1-{4-[7-(2-diethylamino-ethoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phen-
yl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; (276)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-ph-
enyl}-3-phenylacetyl-thiourea; (277)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; (278)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; (279)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; (282)
1-(3-fluoro-4-{7-[2-(4-hydroxymethyl-piperidin-1-yl)-ethoxy]-6-methoxy-qu-
inolin-4-yloxy}-phenyl)-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea;
(283)
1-(3-fluoro-4-{7-[2-(4-hydroxymethyl-piperidin-1-yl)-ethoxy]-6-methoxy-qu-
inolin-4-yloxy}-phenyl)-3-phenylacetylurea; (284)
1-(3-fluoro-4-{7-[2-(4-hydroxymethyl-piperidin-1-yl)-ethoxy]-6-methoxy-qu-
inolin-4-yloxy}-phenyl)-3-phenylacetyl-thiourea; (285)
1-[2-(2-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4--
yl-propoxy)-quinolin-4-yloxy]-phenyl}-thiourea; (286)
1-{2-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(4-fluoro-phenyl)-acetyl]-urea; (287)
1-{2-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-phenyl-acetyl-urea; (288)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; (289)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; (291)
1-{4-[7-(3-diethylamino-propoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phe-
nyl}-3-phenylacetyl-urea; (292)
1-{3-fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-yl-propoxy)-quinolin-4-yloxy]--
phenyl}-3-phenylacetyl-urea; (293)
1-{4-[7-(3-diethylamino-propoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phe-
nyl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea; (294)
1-{3-fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-yl-propoxy)-quinolin-4-yloxy]--
phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea; (295)
1-{3-fluoro-4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea; (296)
1-(3-fluoro-4-{6-methoxy-7-[3-(4-methyl-piperazin-1-yl)-propoxy]-quinolin-
-4-yloxy}-phenyl)-3-[2-(2-fluoro-phenyl)-acetyl]-urea; (297)
1-(3-fluoro-4-{6-methoxy-7-[3-(4-methyl-piperazin-1-yl)-propoxy]-quinolin-
-4-yloxy}-phenyl)-3-(2-m-toluoyl-acetyl)-thiourea; (298)
1-{3-chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; (299)
1-{3-chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; (300)
1-{3-chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-phenylacetyl-thiourea; (301)
1-{3-chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-(2-o-toluoyl-acetyl)-thiourea; (302)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-(2-o-toluoyl-acetyl)-thiourea; (303)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-(2-m-toluoyl-acetyl)-thiourea; (304)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-(2-p-toluoyl-acetyl)-thiourea; (305)
1-{3-fluoro-4-[7-(3-imidazol-1-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-ph-
enyl}-3-phenylacetyl-urea; (306)
1-{3-fluoro-4-[7-(3-imidazol-1-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-ph-
enyl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea; (307)
1-{3-fluoro-4-[7-(3-imidazol-1-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-ph-
enyl}-3-phenylacetyl-thiourea; (308)
1-(3-fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-methoxy-q-
uinolin-4-yloxy}-phenyl)-3-phenylacetyl-urea; (309)
1-(3-fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-methoxy-q-
uinolin-4-yloxy}-phenyl)-3-phenylacetyl-thiourea; (310)
1-(3-fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-methoxy-q-
uinolin-4-yloxy}-phenyl)-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea;
(311)
1-(2-fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-methoxy-q-
uinolin-4-yloxy}-phenyl)-3-phenylacetyl-urea; (312)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-phenylacetyl-thiourea; (313)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; (314)
1-[2-(2-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; (315)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; (316)
1-[2-(2-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; (317)
1-[2-(2-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-
-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; (318)
1-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; (319)
1-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin-
-4-yloxy]-phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; (320)
1-[2-(3-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; (321)
1-[2-(3-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; (322)
1-[2-(3-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-
-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; (323)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; (324)
1-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; (325)
1-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin-
-4-yloxy]-phenyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; (326)
1-[2-(4-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; (327)
1-[2-(4-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; (328)
1-[2-(4-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-
-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; (329)
1-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; (330)
1-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin-
-4-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; (331)
1-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-(2-phenylacetyl)-thiourea; (332)
1-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin-
-4-yloxy]-phenyl}-3-(2-phenylacetyl)-thiourea; (333)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-(2-o-toluoyl-acetyl)-thiourea; (334)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-(2-m-toluoyl-acetyl)-thiourea; (335)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-(2-p-toluoyl-acetyl)-thiourea; (336)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-urea; and (337)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-(2-phenylacetyl)-urea.
17-22. (canceled)
23: The method according to claim 1, wherein said malignant tumor
is selected from the group consisting of gastric cancer, brain
tumors, colon cancer, pancreatic cancer, lung cancer, renal cancer,
ovarian cancer, and prostate cancer.
Description
BACKGROUND OF THE INVENTION
[0001] 1. Field of the Invention
[0002] The present invention relates to quinoline derivatives and
quinazoline derivatives which have antitumor activity. More
particularly, the present invention relates to quinoline
derivatives and quinazoline derivatives which have inhibitory
activity against the autophosphorylation of hepatocyte growth
factor receptors and have inhibitory activity against abnormal cell
proliferation or cell movement.
[0003] 2. Background Art
[0004] Growth factors such as epithelial growth factors,
platelet-derived growth factors, insulin-like growth factors, and
hepatocyte growth factors (hereinafter abbreviated to "HGF") play
an important role in cell proliferation. Among others, HGF is known
to be involved, as a liver regenerating factor and a kidney
regenerating factor, in the regeneration of damaged liver and
kidney (Oncogenesis, 3, 27 (1992)).
[0005] However, the overexpression of HGF and a receptor thereof
(hereinafter abbreviated to "met") is reported to be found in
various tumors such as brain tumors, lung cancer, gastric cancer,
pancreatic cancer, colon cancer, ovarian cancer, renal cancer, and
prostate cancer (Oncology Reports, 5, 1013 (1998)). In particular,
in gastric cancer, excessive development of met and an increase in
HGF level of serum mainly in scirrhous gastric cancers are reported
(Int. J. Cancer, 55, 72, (1993)). Further, it is also known that
HGF has angiogenesis activity due to the acceleration of the
proliferation and migration of vascular endothelial cells
(Circulation, 97, 381 (1998), and Clinical Cancer Res., 5, 3695,
(1999)) and induces the dispersion and invasion of cells (J Biol
Chem, 270, 27780 (1995)). For this reason, HGF-met signals are
considered to be involved in the proliferation, invasion, and
metastasis of various cancer cells.
[0006] NK4, a partial peptide of HGF, is reported as an HGF
receptor antagonist. For example, it is reported that NK4 inhibits
met phosphorylation of various cancer cells and, further,
suppresses cell movement and cell invasion and has tumor growth
inhibitory activity in in-vivo cancer xenograft models probably
through angiogenesis inhibitory activity (Oncogene, 17, 3045
(1998), Cancer Res., 60, 6737 (2000), British J Cancer, 84, 864
(2001), and Int J Cancer, 85, 563 (2000)).
[0007] Since, however, NK4 is a peptide, the use of NK4 as a
therapeutic agent requires a design regarding reliable stability in
vivo, administration method and the like. On the other hand, there
is no report on low toxic orally active small molecule compounds
having met autophosphorylation inhibitory activity.
SUMMARY OF THE INVENTION
[0008] The present inventors have found that a certain group of
quinoline derivatives and quinazoline derivatives have met
autophosphorylation inhibitory activity and, at the same time, have
antitumor effects.
[0009] An object of the present invention is to provide compounds
having potent antitumor activity.
[0010] According to the present invention, there is provided a
compound represented by formula (I) or a pharmaceutically
acceptable salt or solvate thereof:
##STR00002##
wherein
[0011] X represents CH or N;
[0012] Z represents O or S;
[0013] L represents O or S;
[0014] M represents
[0015] --C(--R.sup.10)(--R.sup.11)-- wherein R.sup.10 and R.sup.11,
which may be the same or different, represent a hydrogen atom,
C.sub.1-4 alkyl, or C.sub.1-4 alkoxy, or
[0016] --N(--R.sup.12)-- wherein R.sup.12 represents a hydrogen
atom or C.sub.1-4 alkyl;
[0017] R.sup.1, R.sup.2, and R.sup.3, which may be the same or
different, represent
[0018] a hydrogen atom,
[0019] hydroxyl,
[0020] a halogen atom,
[0021] nitro,
[0022] amino,
[0023] C.sub.1-6 alkyl,
[0024] C.sub.2-6 alkenyl,
[0025] C.sub.2-6 alkynyl, or
[0026] C.sub.1-6 alkoxy,
[0027] in which one or two hydrogen atoms on the amino group are
optionally substituted by C.sub.1-6 alkyl which is optionally
substituted by hydroxyl or C.sub.1-6 alkoxy, and
[0028] in which the C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6
alkynyl, and C.sub.1-6 alkoxy groups are optionally substituted by
hydroxyl; a halogen atom; C.sub.1-6 alkoxy; C.sub.1-6
alkylcarbonyl; C.sub.1-6 alkoxy carbonyl; amino on which one or two
hydrogen atoms is optionally substituted by C.sub.1-6 alkyl which
is optionally substituted by hydroxyl or C.sub.1-6 alkoxy; or a
saturated or unsaturated three- to eight-membered carbocyclic or
heterocyclic group which is optionally substituted by C.sub.1-6
alkyl which is optionally substituted by hydroxyl or C.sub.1-6
alkoxy;
[0029] R.sup.4 represents a hydrogen atom;
[0030] R.sup.5, R.sup.6, R.sup.7, and R.sup.8, which may be the
same or different, represent a hydrogen atom, a halogen atom,
C.sub.1-4 alkyl, or C.sub.1-4 alkoxy;
[0031] R.sup.9 represents
[0032] C.sub.1-6 alkyl on which one or more hydrogen atoms are
optionally substituted by --R.sup.14, -T-R.sup.15, or
--NR.sup.16R.sup.17 wherein T represents --O--, --S--, or --NH--;
R.sup.14 represents a saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; R.sup.15,
R.sup.16, and R.sup.17, which may be the same or different,
represent C.sub.1-6 alkyl or a saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; the three- to
eight-membered carbocyclic or heterocyclic group represented by
R.sup.14, R.sup.15, R.sup.16, and R.sup.17 is optionally
substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom,
nitro, trifluoromethyl, C.sub.1-6 alkoxy carbonyl, cyano, cyano
C.sub.1-6 alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a
saturated or unsaturated five- or six-membered heterocyclic ring;
when the three- to eight-membered carbocyclic or heterocyclic group
is substituted by two C.sub.1-6 alkyl groups, the two alkyl groups
may combine together to form an alkylene chain; and the three- to
eight-membered carbocyclic or heterocyclic group may be a bicyclic
group condensed with another saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group,
[0033] --N(--R.sup.18)(--R.sup.19) wherein R.sup.18 and R.sup.19,
which may be the same or different, represent a hydrogen atom;
C.sub.1-6 alkyl which is optionally substituted by C.sub.1-6
alkoxy, C.sub.1-6 alkylthio, or a saturated or unsaturated three-
to eight-membered carbocyclic or heterocyclic group in which the
three- to eight-membered carbocyclic or heterocyclic group is
optionally substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a
halogen atom, nitro, trifluoromethyl, C.sub.1-6 alkoxy carbonyl,
cyano, cyano C.sub.1-6 alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl,
or a saturated or unsaturated five- or six-membered heterocyclic
ring and, when the three- to eight-membered carbocyclic or
heterocyclic group is substituted by two C.sub.1-6 alkyl groups,
the two alkyl groups may combine together to form an alkylene
chain, or the three- to eight-membered carbocyclic or heterocyclic
group may be a bicyclic group condensed with another saturated or
unsaturated three- to eight-membered carbocyclic or heterocyclic
group; or a saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group which is optionally substituted
by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom, nitro,
trifluoromethyl, C.sub.1-6 alkoxy carbonyl, cyano, cyano C.sub.1-6
alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a saturated or
unsaturated five- or six-membered heterocyclic ring and in which,
when the three- to eight-membered carbocyclic or heterocyclic group
is substituted by two C.sub.1-6 alkyl groups, the two alkyl groups
may combine together to form an alkylene chain, or the three- to
eight-membered carbocyclic or heterocyclic group may be a bicyclic
group condensed with another saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group, or a saturated or
unsaturated three- to eight-membered carbocyclic or heterocyclic
group which is optionally substituted by C.sub.1-6 alkyl, C.sub.1-6
alkoxy, a halogen atom, nitro, trifluoromethyl, C.sub.1-6 alkoxy
carbonyl, cyano, cyano C.sub.1-6 alkyl, C.sub.1-6 alkylthio,
phenoxy, acetyl, or a saturated or unsaturated five- or
six-membered heterocyclic ring and in which, when the three- to
eight-membered carbocyclic or heterocyclic group is substituted by
two C.sub.1-6 alkyl groups, the two alkyl groups may combine
together to form an alkylene chain, or the three- to eight-membered
carbocyclic or heterocyclic group may be a bicyclic group condensed
with another saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group,
[0034] provided that, when X represents CH; Z represents O; L
represents an oxygen atom; M represents --NH--; R.sup.1, R.sup.4,
R.sup.5, R.sup.6, R.sup.7, and R.sup.8 represent a hydrogen atom;
and R.sup.2 and R.sup.3 represent methoxy, R.sup.9 does not
represent phenyl, ethoxy, or pyridin-2-yl.
[0035] The compound according to the present invention can be used
for the treatment of malignant tumors.
DETAILED DESCRIPTION OF THE INVENTION
Compound
[0036] The terms "alkyl," "alkoxy," "alkenyl," and "alkynyl" as
used herein as a group or a part of a group respectively mean
straight chain or branched chain alkyl, alkoxy, alkenyl, and
alkynyl.
[0037] C.sub.1-6 alkyl is preferably C.sub.1-4 alkyl.
[0038] C.sub.1-6 alkoxy is preferably C.sub.1-4 alkoxy.
[0039] C.sub.2-6 alkenyl is preferably C.sub.2-4 alkenyl.
[0040] C.sub.2-6 alkynyl is preferably C.sub.2-4 alkynyl.
[0041] Examples of C.sub.1-6 alkyl include methyl, ethyl, n-propyl,
isopropyl, n-butyl, i-butyl, s-butyl, t-butyl, n-pentyl, and
n-hexyl.
[0042] Examples of C.sub.1-6 alkoxy include methoxy, ethoxy,
n-propoxy, i-propoxy, n-butoxy, i-butoxy, s-butoxy, and
t-butoxy.
[0043] Examples of C.sub.2-6 alkenyl include allyl, butenyl,
pentenyl, and hexenyl.
[0044] Examples of C.sub.2-6 alkynyl include 2-propynyl, butynyl,
pentynyl, and hexynyl.
[0045] The expression "alkyl optionally substituted by" as used
herein refers to alkyl, on which one or more hydrogen atoms are
substituted by one or more substituents which may be the same or
different, and unsubstituted alkyl. It will be understood by those
skilled in the art that the maximum number of substituents may be
determined depending upon the number of substitutable hydrogen
atoms on the alkyl group. This applies to a group having a
substituent other than the alkyl group.
[0046] The term "halogen atom" means a fluorine, chlorine, bromine,
or iodine atom.
[0047] The saturated or unsaturated three- to eight-membered
carbocyclic ring is preferably a four- to seven-membered, more
preferably five- or six-membered, saturated or unsaturated
carbocyclic ring. Examples of saturated or unsaturated three- to
eight-membered carbocyclic rings include phenyl, cyclopropyl,
cyclobutyl, cyclopentyl, cyclohexyl, and cycloheptyl.
[0048] The saturated or unsaturated three- to eight-membered
heterocyclic ring contains at least one hetero-atom selected from
oxygen, nitrogen, and sulfur atoms.
[0049] The saturated or unsaturated three- to eight-membered
heterocyclic ring preferably contains one or two hetero-atoms with
the remaining ring-constituting atoms being carbon atoms. The
saturated or unsaturated three- to eight-membered heterocyclic ring
is preferably a saturated or unsaturated four- to seven-membered
heterocyclic ring, more preferably a saturated or unsaturated five-
or six-membered heterocyclic ring. Examples of saturated or
unsaturated three- to eight-membered heterocyclic groups include
thienyl, pyridyl, 1,2,3-triazolyl, imidazolyl, isoxazolyl,
pyrazolyl, piperazinyl, piperazino, piperidyl, piperidino,
morpholinyl, morpholino, homopiperazinyl, homopiperazino,
thiomorpholinyl, thiomorpholino, tetrahydropyrrolyl, and
azepanyl.
[0050] The saturated or unsaturated carboxylic and heterocyclic
groups may condense with another saturated or heterocyclic group to
form a bicyclic group, preferably a saturated or unsaturated nine-
to twelve-membered bicyclic carbocyclic or heterocyclic group.
[0051] Bicyclic groups include naphthyl, quinolyl,
1,2,3,4-tetrahydroquinolyl, 1,4-benzoxanyl, indanyl, indolyl, and
1,2,3,4-tetrahydronaphthyl.
[0052] When the carbocyclic or heterocyclic group is substituted by
two C.sub.1-6 alkyl groups, the two alkyl groups may combine
together to form an alkylene chain, preferably a C.sub.1-3 alkylene
chain. Carbocyclic or heterocyclic groups having this crosslinked
structure include bicyclo[2.2.2]octanyl and norbornanyl.
[0053] R.sup.1 preferably represents a hydrogen atom.
[0054] R.sup.2 and R.sup.3 preferably represents a group other than
a hydrogen atom. More preferably, R.sup.2 represents unsaturated
C.sub.1-6 alkoxy, still further preferably methoxy, and R.sup.3
represents optionally substituted C.sub.1-6 alkoxy.
[0055] The substituent of substituted C.sub.1-6 alkoxy, which may
be represented by R.sup.3, is preferably a halogen atom, hydroxyl,
amino optionally mono- or disubstituted by optionally substituted
C.sub.1-6 alkyl, or optionally substituted saturated or unsaturated
three- to eight-membered carbocyclic or heterocyclic group, more
preferably a saturated or unsaturated five- to seven-membered
carbocyclic or heterocyclic group. Such substituents include amino
mono- or disubstituted by C.sub.1-6 alkyl, phenyl, piperazinyl,
piperazino, piperidyl, piperidino, morpholinyl, morpholino,
homopiperazinyl, homopiperazino, thiomorpholinyl, thiomorpholino,
tetrahydropyrrolyl, azepanyl, imidazolyl, diazepanyl, and
pyrrolidyl.
[0056] Optionally substituted alkoxy represented by R.sup.3
preferably represents --O--(CH.sub.2)m-R.sup.13 wherein m is an
integer of 1 to 6, R.sup.13 is a substituent of the alkoxy group,
that is, hydroxyl, a halogen atom, C.sub.1-6 alkoxy, C.sub.1-6
alkylcarbonyl, C.sub.1-6 alkoxy carbonyl, optionally substituted
amino, or an optionally substituted saturated or unsaturated three-
to eight-membered carbocyclic or heterocyclic group.
[0057] Preferably, all of R.sup.5, R.sup.6, R.sup.7, and R.sup.8
represent a hydrogen atom, or alternatively any one or two of
R.sup.5, R.sup.6, R.sup.7, and R.sup.8 represent a group other than
a hydrogen atom with all the remaining groups representing a
hydrogen atom.
[0058] Carbocylic group represented by R.sup.9, R.sup.14, R.sup.15,
R.sup.16, R.sup.17, R.sup.18 and R.sup.19 and R.sup.109, R.sup.114,
R.sup.115, R.sup.116, R.sup.117, R.sup.118, R.sup.119, R.sup.209
R.sup.214, R.sup.215, R.sup.216, R.sup.217, R.sup.218, R.sup.219,
R.sup.319, R.sup.419, and R.sup.520, which will be described later,
and carbocylic groups on the alkyl group represented by these
groups include phenyl, cyclopropyl, cyclobutyl, cyclopentyl,
cyclohexyl, cycloheptyl, naphthyl, indanyl, and
1,2,3,4-tetrahydronaphthyl. Preferred substituents of the
carbocyclic group include a fluorine atom, a chlorine atom, methyl,
and methoxy. Examples of preferred carbocyclic groups include
phenyl and naphthyl.
[0059] Heterocyclic groups represented by R.sup.9, R.sup.14,
R.sup.15, R.sup.16, R.sup.17, R.sup.18, and R.sup.19 and R.sup.109,
R.sup.114, R.sup.115, R.sup.116, R.sup.117, R.sup.118, R.sup.119,
R.sup.209, R.sup.214, R.sup.215, R.sup.216, R.sup.217, R.sup.218,
R.sup.219, R.sup.319, R.sup.419, and R.sup.520, which will be
described later, and heterocyclic groups on the alkyl group
represented by these groups include thienyl, pyridyl,
tetrahydropyrrolyl, indolyl, 1,2,3-triazolyl, imidazolyl,
isoxazolyl, pyrazolyl, quinolyl, 1,2,3,4-tetrahydroquinolyl,
thiomorpholino, and 1,4-benzoxanyl. Preferred substituents of the
heterocyclic group include a chlorine atom, a bromine atom, and
methyl. Examples of preferred heterocyclic groups include thienyl,
pyridyl, isoxazolyl, and quinolyl.
[0060] The optionally substituted alkyl group represented by
R.sup.9 preferably represents --(CH.sub.2)p-R.sup.14,
--(CH.sub.2)p-T-R.sup.15, or --(CH.sub.2)p-NR.sup.16R.sup.17
wherein p is an integer of 1 to 6 and R.sup.14, R.sup.15, R.sup.16,
and R.sup.17 are as defined above.
[0061] In --N(--R.sup.18)(--R.sup.19) represented by R.sup.9,
preferably, R.sup.16 represents a hydrogen atom or C.sub.1-6 alkyl,
and R.sup.19 represents C.sub.1-6 alkyl which is optionally
substituted by an optionally substituted saturated or unsaturated
five- or six-membered carbocyclic or heterocyclic group; or an
optionally substituted saturated or unsaturated five- or
six-membered carbocyclic or heterocyclic group.
[0062] Preferred examples of R.sup.9 include benzyl, fluorobenzyl,
difluorobenzyl, chlorobenzyl, methylbenzyl, methoxybenzyl, anilino,
fluoroanilino, difluoroanilino, chloroanilino, methylanilino,
methoxyanilino, naphthyl, thienyl-2-yl-methyl, and
thienyl-3-yl-methyl.
[0063] Both R.sup.10 and R.sup.11 preferably represent a hydrogen
atom or alkyl, or alternatively any one of R.sup.10 and R.sup.11
represents alkoxy with the other group representing a hydrogen
atom.
[0064] R.sup.12 preferably represents a hydrogen atom.
[0065] Examples of preferred compounds according to the present
invention include
[0066] compounds of formula (I) wherein X represents CH or N, Z
represents O, L represents O, and M represents
--N(--R.sup.12)--,
[0067] compounds of formula (I) wherein X represents CH or N, Z
represents O, L represents O, M represents
--C(--R.sup.10)(--R.sup.11)--, and
[0068] compounds of formula (I) wherein X represents CH or N, Z
represents O, L represents S, and M represents
--N(--R.sup.12)--.
[0069] Another examples of preferred compounds according to the
present invention include
[0070] compounds of formula (I) wherein X represents CH or N, Z
represents O, L represents O, M represents --N(--R.sup.12)--,
R.sup.1 and R.sup.4 represent a hydrogen atom, R.sup.2 represents
unsubstituted C.sub.1-6 alkoxy, R.sup.3 represents optionally
substituted C.sub.1-6 alkoxy, and all of R.sup.5, R.sup.6, R.sup.7,
and R.sup.8 represent a hydrogen atom or alternatively any one of
R.sup.5, R.sup.6, R.sup.7, and R.sup.8 represents a group other
than a hydrogen atom with all the remaining groups representing a
hydrogen atom,
[0071] compounds of formula (I) wherein X represents CH or N, Z
represents O, L represents O, M represents
--C(--R.sup.10)(--R.sup.11)--, R.sup.1 and R.sup.4 represent a
hydrogen atom, R.sup.2 represents unsubstituted C.sub.1-6 alkoxy,
R.sup.3 represents optionally substituted C.sub.1-6 alkoxy, and all
of R.sup.5, R.sup.6, R.sup.7, and R.sup.8 represent a hydrogen atom
or alternatively any one of R.sup.5, R.sup.6, R.sup.7, and R.sup.8
represents a group other than a hydrogen atom with all the
remaining groups representing a hydrogen atom, and
[0072] compounds of formula (I) wherein X represents CH or N, Z
represents O, L represents S, M represents --N(--R.sup.12)--,
R.sup.1 and R.sup.4 represent a hydrogen atom, R.sup.2 represents
unsubstituted C.sub.1-6 alkoxy, R.sup.3 represents optionally
substituted C.sub.1-6 alkoxy, all of R.sup.5, R.sup.6, R.sup.7, and
R.sup.8 represent a hydrogen atom or alternatively any one of
R.sup.5, R.sup.6, R.sup.7, and R.sup.8 represents a group other
than a hydrogen atom with all the remaining groups representing a
hydrogen atom.
[0073] Examples of preferred compounds according to the present
invention include compounds represented by formula (100):
##STR00003##
wherein
[0074] R.sup.103 represents hydroxyl or C.sub.1-4 alkoxy which is
optionally substituted by a halogen atom; hydroxyl; amino on which
one or two hydrogen atoms are optionally substituted by C.sub.1-6
alkyl which is optionally substituted by hydroxyl or C.sub.1-6
alkoxy; or a saturated or unsaturated five- to seven-membered
carbocyclic or heterocyclic group which is optionally substituted
by C.sub.1-6 alkyl which is optionally substituted by hydroxyl or
C.sub.1-6 alkoxy,
[0075] R.sup.105, R.sup.106, R.sup.107, and R.sup.108, which may be
the same or different, represents a hydrogen atom, a halogen atom,
C.sub.1-4 alkyl, or C.sub.1-4 alkoxy, and
[0076] R.sup.109 represents
[0077] C.sub.1-6 alkyl on which one or more hydrogen atoms are
optionally substituted by --R.sup.114, -T-R.sup.115, or
--NR.sup.116R.sup.117 in which T represents --O--, --S--, or
--NH--; R.sup.114 represents saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; R.sup.115
represents C.sub.1-6 alkyl or a saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; R.sup.116 and
R.sup.117, which may be the same or different, represent C.sub.1-6
alkyl or a saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group; the three- to eight-membered
carbocyclic or heterocyclic group represented by R.sup.114,
R.sup.115, R.sup.116, and R.sup.117 is optionally substituted by
C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom, nitro,
trifluoromethyl, C.sub.1-6 alkoxy carbonyl, cyano, cyano C.sub.1-6
alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a saturated or
unsaturated five- or six-membered heterocyclic ring; when the
three- to eight-membered carbocyclic or heterocyclic group is
substituted by two C.sub.1-6 alkyl groups, the two alkyl groups may
combine together to form an alkylene chain, or the three- to
eight-membered carbocyclic or heterocyclic group may be a bicyclic
group condensed with another saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group or
[0078] a saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group which is optionally substituted
by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom, nitro,
trifluoromethyl, C.sub.1-6 alkoxycarbonyl, cyano, cyano C.sub.1-6
alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a saturated or
unsaturated five- or six-membered heterocyclic ring; when the
three- to eight-membered carbocyclic or heterocyclic group is
substituted by two C.sub.1-6 alkyl groups, the two alkyl groups may
combine together to form an alkylene chain; and the three- to
eight-membered carbocyclic or heterocyclic group may be a bicyclic
group condensed with another saturated or unsaturated three- to
eight-carbocyclic or heterocyclic group.
[0079] Preferably, all of R.sup.105, R.sup.106, R.sup.107, and
R.sup.108 represent a hydrogen atom or alternatively any one of
R.sup.105, R.sup.106, R.sup.107, and R.sup.108 represents a group
other than a hydrogen atom with all the remaining groups
representing a hydrogen atom.
[0080] In formula (100), the optionally substituted alkyl group
represented by R.sup.109 preferably represents
--(CH.sub.2)p-R.sup.114, --(CH.sub.2)p-T-R.sup.115, or
--(CH.sub.2)p-NR.sup.116R.sup.117 wherein p is an integer of 1 to 6
and R.sup.114, R.sup.115, R.sup.116, and R.sup.117 are as defined
above.
[0081] In --N(--R.sup.118)(--R.sup.119) represented by R.sup.109,
preferably, R.sup.118 represents a hydrogen atom or C.sub.1-6
alkyl, and R.sup.119 represents C.sub.1-6 alkyl which is optionally
substituted by an optionally substituted saturated or unsaturated
five- or six-membered carbocyclic or heterocyclic group; or an
optionally substituted saturated or unsaturated five- or
six-membered carbocyclic or heterocyclic group.
[0082] Preferred examples of R.sup.109 include benzyl,
fluorobenzyl, difluorobenzyl, chlorobenzyl, methylbenzyl,
methoxybenzyl, naphthyl, and thienyl.
[0083] Examples of preferred compounds according to the present
invention include compounds of formula (200):
##STR00004##
wherein
[0084] R.sup.203 represents hydroxyl or C.sub.1-4 alkoxy which is
optionally substituted by a halogen atom; hydroxyl; amino on which
one or two hydrogen atoms are optionally substituted by C.sub.1-6
alkyl which is optionally substituted by hydroxyl or C.sub.1-6
alkoxy; or a saturated or unsaturated five- to seven-membered
carbocyclic or heterocyclic group which is optionally substituted
by C.sub.1-6 alkyl which is optionally substituted by hydroxyl or
C.sub.1-6 alkoxy,
[0085] R.sup.206, R.sup.207, and R.sup.208, which may be the same
or different, represent a hydrogen atom, a halogen atom, C.sub.1-4
alkyl, or C.sub.1-4 alkoxy, and
[0086] R.sup.209 represents
[0087] C.sub.1-6 alkyl on which one or more hydrogen atoms are
optionally substituted by --R.sup.214, -T-R.sup.215, or
--NR.sup.216R.sup.217 wherein T represents --O--, --S--, or --NH--;
R.sup.214 represents a saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; R.sup.215
represents C.sub.1-6 alkyl or a saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group; R.sup.216 and
R.sup.217, which may be the same or different, represent C.sub.1-6
alkyl or a saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group; the three- to eight-membered
carbocyclic or heterocyclic group represented by R.sup.214,
R.sup.215, R.sup.216, and R.sup.217 is optionally substituted by
C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom, nitro,
trifluoromethyl, C.sub.1-6 alkoxy carbonyl, cyano, cyano C.sub.1-6
alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a saturated or
unsaturated five- or six-membered heterocyclic ring; when the
three- to eight-membered carbocyclic or heterocyclic group is
substituted by two C.sub.1-6 alkyl groups, the two alkyl groups may
combine together to form an alkylene chain; and the three- to
eight-membered carbocyclic or heterocyclic group may be a bicyclic
group condensed with another saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group, or
[0088] a saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group which is optionally substituted
by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom, nitro,
trifluoromethyl, C.sub.1-6 alkoxy carbonyl, cyano, cyano C.sub.1-6
alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a saturated or
unsaturated five- or six-membered heterocyclic ring; when the
three- to eight-membered carbocyclic or heterocyclic group is
substituted by two C.sub.1-6 alkyl groups, the two alkyl groups may
combine together to form an alkylene chain; and the three- to
eight-membered carbocyclic or heterocyclic group may be a bicyclic
group condensed with another saturated or unsaturated three- to
eight-membered carbocyclic or heterocyclic group.
[0089] Preferably, all of R.sup.205, R.sup.206, R.sup.207 and
R.sup.208 represent a hydrogen atom, or alternatively any one of
R.sup.205, R.sup.206, R.sup.207, and R.sup.208 represents a group
other than a hydrogen atom with all the remaining groups
representing a hydrogen atom.
[0090] In formula (200), preferably, the optionally substituted
alkyl group represented by R.sup.209 represents
--(CH.sub.2)p-R.sup.214, --(CH.sub.2)p-T-R.sup.215, or
--(CH.sub.2)p-NR.sup.216R.sup.217 wherein p is an integer of 1 to
6, R.sup.214, R.sup.215, R.sup.216, and R.sup.217 are as defined
above.
[0091] In --N(--R.sup.218)(--R.sup.219) represented by R.sup.209,
preferably, R.sup.218 represents a hydrogen atom or C.sub.1-6
alkyl, and R.sup.219 represents C.sub.1-6 alkyl which is optionally
substituted by an optionally substituted saturated or unsaturated
five- or six-membered carbocyclic or heterocyclic group; or an
optionally substituted saturated or unsaturated five- or
six-membered carbocyclic or heterocyclic group.
[0092] Preferred examples of R.sup.209 include benzyl,
fluorobenzyl, difluorobenzyl, chlorobenzyl, methylbenzyl, and
methoxybenzyl.
[0093] Examples of preferred compounds according to the present
invention include compounds represented by formula (300):
##STR00005##
wherein
[0094] R.sup.303 represents hydroxyl or C.sub.1-4 alkoxy which is
optionally substituted by a halogen atom or a saturated or
unsaturated six-membered carbocyclic or heterocyclic group which is
optionally substituted by C.sub.1-6 alkyl which is optionally
substituted by hydroxyl or C.sub.1-6 alkoxy,
[0095] R.sup.305, R.sup.306, R.sup.307, and R.sup.308, which may be
the same or different, represent a hydrogen atom, a halogen atom,
C.sub.1-4 alkyl, or C.sub.1-4 alkoxy,
[0096] R.sup.310 and R.sup.311 represent a hydrogen atom, C.sub.1-4
alkyl, or C.sub.1-4 alkoxy,
[0097] R.sup.318 represents a hydrogen atom or C.sub.1-4 alkyl,
[0098] R.sup.319 represents
[0099] C.sub.1-4 alkyl which is optionally substituted by a
saturated or unsaturated six-membered carbocyclic group which is
optionally substituted by C.sub.1-6 alkyl; C.sub.1-6 alkoxy; a
halogen atom; nitro; trifluoromethyl; C.sub.1-6 alkoxy carbonyl;
cyano; cyano C.sub.1-6 alkyl; C.sub.1-6 alkylthio; phenoxy; acetyl;
or a saturated or unsaturated five- or six-membered heterocyclic
ring and in which, when substituted by two C.sub.1-6 alkyl groups,
the two alkyl groups may combine together to form an alkylene
chain, or may be a bicyclic group condensed with another saturated
or unsaturated three- to eight-membered carbocyclic or heterocyclic
group, or
[0100] a saturated or unsaturated four- to seven-membered
carbocyclic or heterocyclic group which is optionally substituted
by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom, nitro,
trifluoromethyl, C.sub.1-6 alkoxy carbonyl, cyano, cyano C.sub.1-6
alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a saturated or
unsaturated five- or six-membered heterocyclic ring; when the four-
to seven-membered carbocyclic or heterocyclic group is substituted
by two C.sub.1-6 alkyl groups, the two alkyl groups may combine
together to form an alkylene chain; and the four- to seven-membered
carbocyclic or heterocyclic group may be a bicyclic group condensed
with another saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group.
[0101] Preferably, all of R.sup.305, R.sup.306, R.sup.307, and
R.sup.308 represent a hydrogen atom, or alternatively any one of
R.sup.305, R.sup.306, R.sup.307, and R.sup.308 represents a group
other than a hydrogen atom with all the remaining groups
representing a hydrogen atom.
[0102] Preferred examples of R.sup.319 include phenyl,
fluorophenyl, difluorophenyl, chlorophenyl, methylphenyl, and
methoxyphenyl.
[0103] Examples of preferred compounds according to the present
invention include compounds represented by formula (400):
##STR00006##
[0104] wherein
[0105] R.sup.405, R.sup.406, R.sup.407, and R.sup.408, which may be
the same or different, represent a hydrogen atom, a halogen atom,
C.sub.1-4 alkyl, or C.sub.1-4 alkoxy,
[0106] R.sup.419 represents an unsaturated five- or six-membered
carbocyclic or heterocyclic group which is optionally substituted
by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, a halogen atom, nitro,
trifluoromethyl, C.sub.1-6 alkoxy carbonyl, cyano, cyano C.sub.1-6
alkyl, C.sub.1-6 alkylthio, phenoxy, acetyl, or a saturated or
unsaturated five- or six-membered heterocyclic ring; when the five-
or six-membered carbocyclic or heterocyclic group is substituted by
two C.sub.1-6 alkyl groups, the two alkyl groups may combine
together to form an alkylene chain; and the five- or six-membered
carbocyclic or heterocyclic group may be a bicyclic group condensed
with another saturated or unsaturated three- to eight-membered
carbocyclic or heterocyclic group.
[0107] Preferably, all of R.sup.405, R.sup.406, R.sup.407 and
R.sup.408 represent a hydrogen atom, or alternatively any one of
R.sup.405, R.sup.406, R.sup.407, and R.sup.408 represents a group
other than a hydrogen atom with all the remaining groups
representing a hydrogen atom.
[0108] Preferred examples of R.sup.419 include phenyl,
fluorophenyl, difluorophenyl, chlorophenyl, methylphenyl,
methoxyphenyl, pyridyl, isoxazolyl, and quinolyl.
[0109] Examples of preferred compounds according to the present
invention include compounds represented by formula (500):
##STR00007##
wherein
[0110] X represents CH or N,
[0111] when L represents O and M represents --N(--R.sup.12)--, Q
represents CH.sub.2 or NH,
[0112] when L represents O and M represents
--C(--R.sup.10)(--R.sup.11)--, Q represents NH,
[0113] when L represents S and M represents --N(--R.sup.12)--, Q
represents CH.sub.2,
[0114] R.sup.503 represents hydroxyl or C.sub.1-4 alkoxy which is
optionally substituted by a halogen atom; hydroxyl; amino on which
one or two hydrogen atoms are optionally substituted by C.sub.1-6
alkyl which is optionally substituted by hydroxyl or C.sub.1-6
alkoxy; or a saturated or unsaturated five- to seven-membered
carbocyclic or heterocyclic group which is optionally substituted
by C.sub.1-6 alkyl which is optionally substituted by hydroxyl or
C.sub.1-6 alkoxy,
[0115] R.sup.505, R.sup.506, R.sup.507, and R.sup.509, which may be
the same or different, represent a hydrogen atom, a halogen atom,
C.sub.1-4 alkyl, or C.sub.1-4 alkoxy, and
[0116] R.sup.520 represents a saturated or unsaturated five- or
six-membered carbocyclic or heterocyclic group which is optionally
substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, or a halogen
atom.
[0117] Preferably, all of R.sup.505, R.sup.506, R.sup.507, and
R.sup.508 represent a hydrogen atom, or alternatively any one of
R.sup.505, R.sup.506, R.sup.507, and R.sup.508 represents a group
other than a hydrogen atom with all the remaining groups
representing a hydrogen atom.
[0118] Examples of preferred compounds according to the present
invention are as follows. The number attached to the compound
represents the number of the corresponding working example
described below. [0119] (1)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-N'-phenylacetylthio-
urea; [0120] (2)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-N'-[2-(4-fluorophen-
yl)acetyl]thiourea; [0121] (3)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-N'-[2-(4-fluorophen-
yl)acetyl]urea; [0122] (4)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-phenyl-acetylurea;
[0123] (5)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(4-fluorophenyl)malona-
mide; [0124] (6)
N-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-N'-(2,4-difluorophe-
nyl)malonamide; [0125] (7)
1-(2-cyclopentylsulfanylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)pheny-
l]urea; [0126] (8)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-[2-(2,3-dihydro-1-
H-1-indol-1-yl)acetyl]-urea; [0127] (9)
N-phenyl-({[4-(6,7-dimethoxyquinolin-4-yloxy)-anilino]carbonyl}amino)meth-
anamide; [0128] (10)
N-(4-fluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; [0129] (11)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-3-phenylacetylurea; [0130] (12)
1-(3-fluoro-4-{6-methoxy-7-[4-(4-methyl-piperazin-1-yl)-butoxy]quinolin-4-
-yloxy}phenyl)-3-phenylacetylurea; [0131] (13)
1-{3-fluoro-4-[6-methoxy-7-(2-piperidin-1-yl-ethoxy)quinolin-4-yloxy]phen-
yl}-3-phenylacetylurea; [0132] (14)
1-{4-[7-(3-chloro-propoxy)-6-methoxyquinolin-4-yloxy]-3-fluorophenyl}-3-p-
henylacetylurea; [0133] (15)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]-2-me-
thylmalonamide; [0134] (16)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-phenylacetylurea;
[0135] (17)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-phenylacetylurea;
[0136] (18)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-phenylacetylurea;
[0137] (19)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-(2-thiophen-3-yla-
cetyl)urea; [0138] (20)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-(2-thiophen-3-yla-
cetyl)urea; [0139] (21)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-(2-thiophen-3-yla-
cetyl)urea; [0140] (22)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(4-fluorophenyl)acetyl]u-
rea; [0141] (23)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-[2-(4-fluoropheny-
l)acetyl]urea; [0142] (24)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(4-fluorophenyl-
)acetyl]urea; [0143] (25)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-fluorophenyl)acetyl]u-
rea; [0144] (26)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-[2-(2-fluoropheny-
l)acetyl]urea; [0145] (27)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(2-fluorophenyl-
)acetyl]urea; [0146] (28)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-[2-(2-fluoropheny-
l)acetyl]urea; [0147] (29)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-thiophen-2-ylacetyl)urea-
; [0148] (30)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-(2-thiophen-2-yla-
cetyl)urea; [0149] (31)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-(2-thiophen-2-yla-
cetyl)urea; [0150] (32)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-(2-thiophen-2-yla-
cetyl)urea; [0151] (33)
1-[2-(2,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]urea; [0152] (34)
1-[2-(2,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; [0153] (35)
1-[2-(3,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; [0154] (36)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-[2-(3-fluoropheny-
l)acetyl]urea; [0155] (37)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-[2-(3-fluoropheny-
l)acetyl]urea; [0156] (38)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-methoxyphenyl]-3-[2-(4-fluoropheny-
l)acetyl]urea; [0157] (39)
1-[2-(3,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phen-
yl]urea; [0158] (40)
1-[4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(4-fluo-
rophenyl)acetyl]urea; [0159] (41)
1-{3-fluoro-4-[6-methoxy-7-(4-morpholin-4-yl-butoxy)quinolin-4-yloxy]phen-
yl}-3-[2-(4-fluorophenyl)-acetyl]urea; [0160] (42)
1-{3-fluoro-4-[6-methoxy-7-(4-piperidine-1-yl-butoxy)quinolin-4-yloxy]phe-
nyl}-3-[2-(4-fluorophenyl)-acetyl]urea; [0161] (43)
1-(3-fluoro-4-{6-methoxy-7-[4-(4-methyl-piperazin-1-yl)-butoxy]quinolin-4-
-yloxy}phenyl)-3-[2-(4-fluorophenyl)acetyl]urea; [0162] (44)
1-{2-fluoro-4-[6-methoxy-7-(4-morpholin-4-yl-butoxy)quinolin-4-yloxy]phen-
yl}-3-[2-(4-fluorophenyl)-acetyl]urea; [0163] (45)
1-{2-fluoro-4-[6-methoxy-7-(4-piperidine-1-yl-butoxy)quinolin-4-yloxy]phe-
nyl}-3-[2-(4-fluorophenyl)-acetyl]urea; [0164] (46)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-3-[2-(4-fluorophenyl)-acetyl]urea; [0165] (47)
1-{3-fluoro-4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-3-[2-(4-fluorophenyl)-acetyl]urea; [0166] (48)
1-{3-fluoro-4-[6-methoxy-7-(2-piperidin-1-yl-ethoxy)quinolin-4-yloxy]phen-
yl}-3-[2-(4-fluorophenyl)-acetyl]urea; [0167] (49)
1-(3-fluoro-4-{6-methoxy-7-[2-(4-methyl-piperazin-1-yl)-ethoxy]quinolin-4-
-yloxy}phenyl)-3-[2-(4-fluorophenyl)acetyl]urea; [0168] (50)
1-{2-fluoro-4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-3-[2-(4-fluorophenyl)-acetyl]urea; [0169] (51)
1-(2-fluoro-4-{6-methoxy-7-[3-(4-methyl-piperazin-1-yl)-propoxy]quinolin--
4-yloxy}phenyl)-3-[2-(4-fluorophenyl)acetyl]urea; [0170] (52)
1-{3-fluoro-4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-3-phenylacetylurea; [0171] (53)
1-(3-fluoro-4-{6-methoxy-7-[3-(4-methyl-piperazin-1-yl)-propoxy]quinolin--
4-yloxy}phenyl)-3-phenylacetylurea; [0172] (54)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)quinolin-4-yloxy]phen-
yl}-3-phenylacetylurea; [0173] (55)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)quinolin-4-yloxy]phen-
yl}-3-[2-(4-fluorophenyl)-acetyl]urea; [0174] (56)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(naphthalene-1-carbonyl)thi-
ourea; [0175] (57)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-(naphthalene-1-ca-
rbonyl)thiourea; [0176] (58)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-phenylacetylthiour-
ea; [0177] (59)
1-[2-(2-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]t-
hiourea; [0178] (60)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-phenylacetylthiourea;
[0179] (61)
1-(2-cyclohexylacetyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]thiour-
ea; [0180] (62)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(3-ethoxypropionyl)thiourea-
; [0181] (63)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-phenylacetylthiou-
rea; [0182] (64)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-(3-o-tolylpropion-
yl)thiourea; [0183] (65)
1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-phenylacetylthiou-
rea; [0184] (66)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-thiophen-2-ylacetyl)thio-
urea; [0185] (67)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-methyl-phenyl]-3-phenylacetylthiou-
rea; [0186] (68)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-methoxyphenyl]-3-phenylacetylthiou-
rea; [0187] (69)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-methoxyphenyl]-3-phenylacetylthiou-
rea; [0188] (70)
1-[3,5-dichloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-phenylacetylth-
iourea; [0189] (71)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(4-fluorophenyl)acetyl]t-
hiourea; [0190] (72)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-[2-(4-fluoropheny-
l)acetyl]thiourea; [0191] (73)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-[2-(4-fluoropheny-
l)acetyl]thiourea; [0192] (74)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-[2-(3-fluoropheny-
l)acetyl]thiourea; [0193] (75)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-[2-(3-fluoropheny-
l)acetyl]thiourea; [0194] (76)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-[2-(3-fluoropheny-
l)acetyl]thiourea; [0195] (77)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-m-tolylacetyl)thiourea;
[0196] (78)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-(2-m-tolylacetyl)-
thiourea; [0197] (79)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-o-tolylacetyl)thiourea;
[0198] (80)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-[2-(2-fluoropheny-
l)acetyl]thiourea; [0199] (81)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-[2-(2-fluoropheny-
l)acetyl]thiourea; [0200] (82)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)-phenyl]-3-(2-p-tolylacetyl)-
thiourea; [0201] (83)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-[2-(2-methoxyphen-
yl)acetyl]thiourea; [0202] (84)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(2-o-tolylacetyl)t-
hiourea; [0203] (85)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoro-phenyl]-3-(2-thiophen-3-yla-
cetyl)thiourea; [0204] (86)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-methoxyphenyl]-3-(2-thiophen-3-yla-
cetyl)thiourea; [0205] (87)
1-[2-(2-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluor-
ophenyl]thiourea; [0206] (88)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
phenyl]thiourea; [0207] (89)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
phenyl]thiourea; [0208] (90)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
-3-fluorophenyl]thiourea; [0209] (91)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[3-chloro-4-(6,7-dimethoxyquinolin-
-4-yloxy)phenyl]thiourea; [0210] (92)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluoro-phenyl]-3-(2-p-tolylacetyl)-
thiourea; [0211] (93)
1-[2-(2,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; [0212] (94)
1-[2-(2,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; [0213] (95)
1-[2-(2,6-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; [0214] (96)
1-[2-(2,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; [0215] (97)
1-[2-(2,6-dichlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; [0216] (98)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluorophe-
nyl]malonamide; [0217] (99)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluorophe-
nyl]malonamide; [0218] (100)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-phenylmalonamide;
[0219] (101)
N-cycloheptyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]malonamid-
e; [0220] (102)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]malon-
amide; [0221] (103)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]-2-me-
thoxymalonamide; [0222] (104)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]-2,2--
dimethylmalonamide; [0223] (105)
N-(4-methyl-2-pyridyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; [0224] (106)
1-[3-fluoro-4-(7-hydroxy-6-methoxyquinolin-4-yloxy)phenyl]-3-phenylacetyl-
urea; [0225] (107)
1-(2-chloro-benzoyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluorophenyl-
]urea; [0226] (108)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-(2-methyl-benzoyl)-
urea; [0227] (109)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-pentanoylurea;
[0228] (110)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-diethylaminoace-
tyl)urea; [0229] (111)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-pyrrolidin-1-yl-
acetyl)urea; [0230] (112)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(isopropylmethy-
lamino)acetyl]urea; [0231] (113)
1-(2-cyclohexylsulfanylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl-
]urea; [0232] (114)
1-(2-cyclohexylsulfanylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-flu-
orophenyl]urea; [0233] (115)
1-(2-cyclohexylsulfanylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-flu-
orophenyl]urea; [0234] (116)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-cyclopentylsulf-
anylacetyl)urea; [0235] (117)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-o-tolylaminoacetyl)urea;
[0236] (118)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-thiophen-3-ylacetyl)urea-
; [0237] (119)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(6-methyl-3,4-d-
ihydro-2H-quinolin-1-yl)acetyl]urea; [0238] (120)
1-[2-(4-benzyl-piperidin-1-yl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy-
)-3-fluorophenyl]urea; [0239] (121)
1-[2-(2,3-dihydro-1H-1-indol-1-yl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-y-
loxy)-2-fluorophenyl]urea; [0240] (122)
1-[2-(2,3-dihydro-1H-1-indol-1-yl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-y-
loxy)-3-fluorophenyl]urea; [0241] (123)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-[1,2,3]triazol--
1-ylacetyl)urea; [0242] (124)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-(2-p-tolylacetyl)u-
rea; [0243] (125)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
phenyl]urea; [0244] (126)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
-2-fluorophenyl]urea; [0245] (127)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-
-3-fluorophenyl]urea; [0246] (128)
1-(2-bicyclo[2.2.1]hepto-7-ylacetyl)-3-[3-chloro-4-(6,7-dimethoxyquinolin-
-4-yloxy)phenyl]urea; [0247] (129)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-phenylsulfanylacetyl)ure-
a; [0248] (130)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(1-methyl-1H-im-
idazol-2-ylsulfanyl)-acetyl]urea; [0249] (131)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-thiomorpholin-4-
-ylacetyl)urea; [0250] (132)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-thiomorpholin-4-
-ylacetyl)urea; [0251] (133)
1-[2-(2,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; [0252] (134)
1-[2-(2,6-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]urea; [0253] (135)
1-[2-(2,6-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; [0254] (136)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(2-trifluoromet-
hylphenyl)acetyl]urea; [0255] (137)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(2-trifluoromet-
hylphenyl)acetyl]urea; [0256] (138)
1-[2-(2,3-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]urea; [0257] (139)
1-[2-(2,3-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; [0258] (140)
1-[2-(3,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]urea; [0259] (141)
1-[2-(3,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]urea; [0260] (142)
1-[2-(3,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]urea; [0261] (143)
1-cyclopentanecarbonyl-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluorophen-
yl]thiourea; [0262] (144)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(3-methoxybenzoyl)-
thiourea; [0263] (145)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(3-trifluoromethyl-benzoyl)-
thiourea; [0264] (146)
1-(2-bromobenzoyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluorophenyl]t-
hiourea;
[0265] (147)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(3-methylsulfanylp-
ropionyl)thiourea; [0266] (148)
1-(4-chloro-butyryl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluorophenyl-
]thiourea; [0267] (149)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-o-tolylacetyl)t-
hiourea; [0268] (150)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-phenylcyclopropanecarbon-
yl)thiourea; [0269] (151)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-fluorophenyl)acetyl]t-
hiourea; [0270] (152)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-fluorophenyl-
)acetyl]thiourea; [0271] (153)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-methoxyphenyl)acetyl]-
thiourea; [0272] (154)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-methoxyphenyl)acetyl]-
thiourea; [0273] (155)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-nitrophenyl)acetyl]th-
iourea; [0274] (156)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-nitrophenyl)-
acetyl]thiourea; [0275] (157)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-phenoxyacetyl)t-
hiourea; [0276] (158)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-phenylpropionyl)thiourea-
; [0277] (159)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(3-ethoxypropionyl-
)thiourea; [0278] (160)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(5-methylthiophen-2-carbony-
l)thiourea; [0279] (161)
1-(3-cyclopentylpropionyl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]thi-
ourea; [0280] (162)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-methylphenyl]-3-phenylacetylthiour-
ea; [0281] (163)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2,5-dimethylphenyl]-3-phenylacetylth-
iourea; [0282] (164)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(3-fluorophenyl)acetyl]t-
hiourea; [0283] (165)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(3-ethoxypropionyl-
)thiourea; [0284] (166)
1-(2-cyclohexylacetyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluorophen-
yl]thiourea; [0285] (167)
1-(2-butoxyacetyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluorophenyl]t-
hiourea; [0286] (168)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(2-p-tolylacetyl)thiourea;
[0287] (169)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(2-methoxypheny-
l)acetyl]thiourea; [0288] (170)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-(2-o-tolylacetyl)t-
hiourea; [0289] (171)
1-[2-(3-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]t-
hiourea; [0290] (172)
1-[2-(3-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluor-
ophenyl]thiourea; [0291] (173)
1-[2-(3-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluor-
ophenyl]thiourea; [0292] (174)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(3-chlorophenyl-
)acetyl]thiourea; [0293] (175)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-(2-m-tolylacetyl)t-
hiourea; [0294] (176)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(2-m-tolylacetyl)t-
hiourea; [0295] (177)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(5-methyl-hexanoyl)thiourea-
; [0296] (178)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-(5-methyl-hexanoyl-
)thiourea; [0297] (179)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(5-methyl-hexanoyl-
)thiourea; [0298] (180)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-(3-methoxy-propion-
yl)thiourea; [0299] (181)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(3-methoxypheny-
l)acetyl]thiourea; [0300] (182)
1-[2-(2-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluor-
ophenyl]thiourea; [0301] (183)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2-chlorophenyl-
)acetyl]thiourea; [0302] (184)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(3-methoxyphenyl)acetyl]-
thiourea; [0303] (185)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(3-methoxypheny-
l)acetyl]thiourea; [0304] (186)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(3-methoxypheny-
l)acetyl]thiourea; [0305] (187)
1-[2-(4-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]t-
hiourea; [0306] (188)
1-[2-(4-chlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluor-
ophenyl]thiourea; [0307] (189)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(4-chlorophenyl-
)acetyl]thiourea; [0308] (190)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(2-p-tolylacetyl)t-
hiourea; [0309] (191)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(4-methyl-cyclo-
hexyl)acetyl]thiourea; [0310] (192)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(4-methyl-cyclo-
hexyl)acetyl]thiourea; [0311] (193)
1-(2-butoxyacetyl)-3-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]th-
iourea; [0312] (194)
1-[2-(2,3-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; [0313] (195)
1-[2-(2,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; [0314] (196)
1-[2-(3,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; [0315] (197)
1-[2-(3,5-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; [0316] (198)
1-[2-(3,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; [0317] (199)
1-[2-(3,4-difluorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-f-
luorophenyl]thiourea; [0318] (200)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(2-trifluoromet-
hylphenyl)acetyl]-thiourea; [0319] (201)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(2-trifluoromet-
hylphenyl)acetyl]-thiourea; [0320] (202)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(3-trifluoromet-
hylphenyl)acetyl]-thiourea; [0321] (203)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(3-trifluoromet-
hylphenyl)acetyl]-thiourea; [0322] (204)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2,3,6-trifluorophenyl)a-
cetyl]thiourea; [0323] (205)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-3-[2-(2,3,6-trifluor-
ophenyl)acetyl]-thiourea; [0324] (206)
1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-[2-(2,3,6-trifluor-
ophenyl)acetyl]-thiourea; [0325] (207)
1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-3-[2-(2,3,6-trifluor-
ophenyl)acetyl]-thiourea; [0326] (208)
1-[2-(2,6-dichlorophenyl)acetyl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-f-
luorophenyl]thiourea; [0327] (209)
N-butyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]malonamide;
[0328] (210)
N-(3-chlorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]mal-
onamide; [0329] (211)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(2-methoxyphenyl)malonamid-
e; [0330] (212)
N-cyclobutyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]malonamide;
[0331] (213) methyl
3-{2-[4-(6,7-dimethoxyquinolin-4-yloxy)phenylcarbamoyl]acetylamino}benzoa-
te; [0332] (214)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(1-phenylethyl)malonamide;
[0333] (215)
N-benzyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]malonamide;
[0334] (216)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-methyl-N'-phenylmalo-
namide; [0335] (217)
N-cyclohexyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]malonamide;
[0336] (218)
N-cyclohexylmethyl-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]malonamid-
e; [0337] (219)
N-(4-chlorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)phenyl]malonamid-
e; [0338] (220)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(3-hydroxyphenyl)malonamid-
e; [0339] (221)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(3,3-dimethyl-butyl)malona-
mide; [0340] (222)
N-[2-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-(2,4-difluorophen-
yl)malonamide; [0341] (223)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-methylphe-
nyl]malonamide; [0342] (224)
N-(2,4-difluorophenyl)-N'-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2,5-dimethy-
lphenyl]malonamide; [0343] (225)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-2-methyl-N'-phenylmalonamide;
[0344] (226)
N-cyclohexyl-N'-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-2-methylmalonam-
ide; [0345] (227)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-N'-pyridin-3-ylmalonamide;
[0346] (228)
N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-2,2-dimethyl-N'-phenylmalonam-
ide; [0347] (229)
N-(2,4-difluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; [0348] (230)
N-(3-bromo-5-methyl-2-pyridyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilin-
o]carbonyl}amino)-methanamide; [0349] (231)
N-(5-chloro-2-pyridyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; [0350] (232)
N-(5-methyl-3-isoxazolyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]car-
bonyl}amino)-methanamide; [0351] (233)
N-(3-methyl-2-pyridyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; [0352] (234)
N-(6-methyl-2-pyridyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; [0353] (235)
N-(5-methyl-2-pyridyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; [0354] (236)
N-(2-pyridyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]carbonyl}amino)-
methanamide; [0355] (237)
N-(1-methyl-1H-5-pyrazolyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]c-
arbonyl}amino)-methanamide; [0356] (238)
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)-
anilino]carbonyl}amino)-methanamide; [0357] (239)
N-(3-cyanophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}a-
mino)-methanamide; [0358] (240)
N-[2-(trifluoromethyl)phenyl]-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino-
]carbonyl}amino)methan-amide; [0359] (241)
N-[4-(cyanomethyl)phenyl]-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]car-
bonyl}amino)-methanamide; [0360] (242)
N-(4-chloro-2-methylphenyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]c-
arbonyl}amino)-methanamide; [0361] (243)
N-(2,3-dihydro-1H-5-indenyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]-
carbonyl}amino)-methanamide; [0362] (244)
N-(3-methoxyphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl-
}amino)methanamide; [0363] (245) methyl
2-({({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]carbonyl}amino)carbonyl}a-
mino)benzoate; [0364] (246)
N-(2-benzylphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; [0365] (247)
N-(2-bromophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}a-
mino)methanamide; [0366] (248)
N-(2-chlorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; [0367] (249)
N-(4-chlorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; [0368] (250)
N-(2-chloro-4-fluorophenyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]c-
arbonyl}amino)-methanamide; [0369] (251)
N-(3-fluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; [0370] (252)
N-(2-fluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; [0371] (253)
N-[2-(methylsulfanyl)phenyl]-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]-
carbonyl}amino)-methanamide; [0372] (254)
N-(4-nitrophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}a-
mino)methanamide; [0373] (255)
N-(2-phenoxyphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl-
}amino)methanamide; [0374] (256)
N-(3-methylphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; [0375] (257)
N-(4-methylphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)methanamide; [0376] (258)
N-(2,6-dimethylphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; [0377] (259)
N-[2-(1H-1-pyrrolyl)phenyl]-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]c-
arbonyl}amino)-methanamide; [0378] (260)
N-(8-quinolyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]carbonyl}amino-
)methanamide; [0379] (261)
N-(3-acetylphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl}-
amino)-methanamide; [0380] (262)
N-(5-quinolyl)-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]carbonyl}amino-
)methanamide; [0381] (263)
N-(2,6-dichlorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; [0382] (264)
N-(3,4-difluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; [0383] (265)
N-(2,6-difluorophenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbo-
nyl}amino)methanamide; [0384] (266)
N-(2-methoxyphenyl)-({[4-(6,7-dimethoxy-quinolin-4-yloxy)anilino]carbonyl-
}amino)methanamide; [0385] (267)
N-[2-(2-hydroxyethyl)phenyl]-({[4-(6,7-dimethoxyquinolin-4-yloxy)anilino]-
carbonyl}amino)-methanamide; [0386] (268)
N-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-N'-phenylacetyl-thiourea; [0387] (269)
N-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)quinolin-4-yloxy]phe-
nyl}-N'-(4-fluorophenyl)-malonamide; [0388] (270)
1-(3-fluoro-4-{6-methoxy-7-[2-(4-methyl-piperazin-1-yl)-ethoxy]-quinolin--
4-yloxy}-phenyl)-3-phenylacetyl-thiourea; [0389] (271)
1-(3-fluoro-4-{6-methoxy-7-[(2-(4-methyl-piperazin-1-yl)-ethoxy]-quinolin-
-4-yloxy}-phenyl)-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; [0390]
(272)
1-{4-[7-(2-diethylamino-ethoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phen-
yl}-3-phenylacetylthio-urea; [0391] (273)
1-(3-fluoro-4-{6-methoxy-7-[2-(4-methyl-[1,4]diazepan-1-yl)-ethoxy]-quino-
lin-4-yloxy}-phenyl)-3-phenylacetyl-thiourea; [0392] (275)
1-{4-[7-(2-diethylamino-ethoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phen-
yl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; [0393] (276)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-ph-
enyl}-3-phenylacetyl-thiourea; [0394] (277)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; [0395] (278)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; [0396] (279)
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; [0397] (282)
1-(3-fluoro-4-{7-[2-(4-hydroxymethyl-piperidin-1-yl)-ethoxy]-6-methoxy-qu-
inolin-4-yloxy}-phenyl)-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea;
[0398] (283)
1-(3-fluoro-4-{7-[2-(4-hydroxymethyl-piperidin-1-yl)-ethoxy]-6-meth-
oxy-quinolin-4-yloxy}-phenyl)-3-phenylacetylurea; [0399] (284)
1-(3-fluoro-4-{7-[2-(4-hydroxymethyl-piperidin-1-yl)-ethoxy]-6-methoxy-qu-
inolin-4-yloxy}-phenyl)-3-phenylacetyl-thiourea; [0400] (285)
1-[2-(2-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4--
yl-propoxy)-quinolin-4-yloxy]-phenyl}-thiourea; [0401] (286)
1-{2-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(4-fluoro-phenyl)-acetyl]-urea; [0402] (287)
1-{2-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-phenyl-acetyl-urea; [0403] (288)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; [0404] (289)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; [0405] (291)
1-{4-[7-(3-diethylamino-propoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phe-
nyl}-3-phenylacetyl-urea; [0406] (292)
1-{3-fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-yl-propoxy)-quinolin-4-yloxy]--
phenyl}-3-phenylacetyl-urea; [0407] (293)
1-{4-[7-(3-diethylamino-propoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phe-
nyl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea;
[0408] (294)
1-{3-fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-yl-propoxy)-quinolin-4-yloxy]--
phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea; [0409] (295)
1-{3-fluoro-4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea; [0410] (296)
1-(3-fluoro-4-{6-methoxy-7-[3-(4-methyl-piperazin-1-yl)-propoxy]-quinolin-
-4-yloxy}-phenyl)-3-[2-(2-fluoro-phenyl)-acetyl]-urea; [0411] (297)
1-(3-fluoro-4-{6-methoxy-7-[3-(4-methyl-piperazin-1-yl)-propoxy]-quinolin-
-4-yloxy}-phenyl)-3-(2-m-toluoyl-acetyl)-thiourea; [0412] (298)
1-{3-chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; [0413] (299)
1-{3-chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; [0414] (300)
1-{3-chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-phenylacetyl-thiourea; [0415] (301)
1-{3-chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-(2-o-toluoyl-acetyl)-thiourea; [0416] (302)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-(2-o-toluoyl-acetyl)-thiourea; [0417] (303)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-(2-m-toluoyl-acetyl)-thiourea; [0418] (304)
1-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-(2-p-toluoyl-acetyl)-thiourea; [0419] (305)
1-{3-fluoro-4-[7-(3-imidazol-1-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-ph-
enyl}-3-phenylacetyl-urea; [0420] (306)
1-{3-fluoro-4-[7-(3-imidazol-1-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-ph-
enyl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea; [0421] (307)
1-{3-fluoro-4-[7-(3-imidazol-1-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-ph-
enyl}-3-phenylacetyl-thiourea; [0422] (308)
1-(3-fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-methoxy-q-
uinolin-4-yloxy}-phenyl)-3-phenylacetyl-urea; [0423] (309)
1-(3-fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-methoxy-q-
uinolin-4-yloxy}-phenyl)-3-phenylacetyl-thiourea; [0424] (310)
1-(3-fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-methoxy-q-
uinolin-4-yloxy}-phenyl)-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea;
[0425] (311)
1-(2-fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-met-
hoxy-quinolin-4-yloxy}-phenyl)-3-phenylacetyl-urea; [0426] (312)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-phenylacetyl-thiourea; [0427] (313)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; [0428]
(314)
1-[2-(2-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; [0429]
(315)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; [0430]
(316)
1-[2-(2-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; [0431]
(317)
1-[2-(2-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-
-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; [0432]
(318)
1-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; [0433]
(319)
1-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin-
-4-yloxy]-phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea; [0434]
(320)
1-[2-(3-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; [0435]
(321)
1-[2-(3-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; [0436]
(322)
1-[2-(3-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-
-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; [0437]
(323)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; [0438]
(324)
1-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; [0439]
(325)
1-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin-
-4-yloxy]-phenyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea; [0440]
(326)
1-[2-(4-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; [0441]
(327)
1-[2-(4-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; [0442]
(328)
1-[2-(4-chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-
-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea; [0443]
(329)
1-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; [0444]
(330)
1-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin-
-4-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea; [0445]
(331)
1-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-(2-phenylacetyl)-thiourea; [0446] (332)
1-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin-
-4-yloxy]-phenyl}-3-(2-phenylacetyl)-thiourea; [0447] (333)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-(2-o-toluoyl-acetyl)-thiourea; [0448] (334)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-(2-m-toluoyl-acetyl)-thiourea; [0449] (335)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-(2-p-toluoyl-acetyl)-thiourea; [0450] (336)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-urea; and [0451]
(337)
1-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-(2-phenylacetyl)-urea.
[0452] Examples of particularly preferred compounds according to
the present invention include compounds 1 to 6, 9 to 13, 16 to 39,
42, 43, 49, 52 to 54, 56 to 102, 105, 106, 266 to 269, 285, 286,
288, 312, 313, 333, and 334.
[0453] Examples of most preferred compounds according to the
present invention include compounds 1, 2, 3, 11, and 268.
[0454] The compounds according to the present invention may form
pharmaceutically acceptable salts thereof. Preferred examples of
such salts include: alkali metal or alkaline earth metal salts such
as sodium salts, potassium salts or calcium salts; hydrohalogenic
acid salts such as hydrofluoride salts, hydrochloride salts,
hydrobromide salts, or hydroiodide salts; inorganic acid salts such
as nitric acid salts, perchloric acid salts, sulfuric acid salts,
or phosphoric acid salts; lower alkylsulfonic acid salts such as
methanesulfonic acid salts, trifluoromethanesulfonic acid salts, or
ethanesulfonic acid salts; arylsulfonic acid salts such as
benzenesulfonic acid salts or p-toluenesulfonic acid salts; organic
acid salts such as fumaric acid salts, succinic acid salts, citric
acid salts, tartaric acid salts, oxalic acid salts, maleic acid
salts, acetic acid salts, malic acid salts, lactic acid salts, or
ascorbic acid salts; and amino acid salts such as glycine salts,
phenylalanine salts, glutamic acid salts, or aspartic acid
salts.
[0455] The compounds according to the present invention may form
solvates. Such solvates include, for example, hydrates,
alcoholates, for example, methanolates and ethanolates, and
etherates, for example, diethyl etherate.
[0456] Production of Compounds
[0457] Compounds according to the present invention may be
produced, for example, according to schemes 1 to 9.
[0458] Starting compounds necessary for the synthesis of the
compounds according to the present invention are commercially
available or alternatively can be easily produced by conventional
methods. In the schemes, R.sup.1, R.sup.2, R.sup.3, R.sup.4,
R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11,
R.sup.18, R.sup.19, and X are as defined above; PG represents a
protective group; R.sup.3'O represents optionally substituted
alkoxy; Hal represents a halogen atom; R.sup.51 and R.sup.52, which
may be the same or different, represent optionally substituted
C.sub.1-6 alkyl, or alternatively R.sup.51 and R.sup.52 may combine
to form a saturated or unsaturated three- to eight-membered
heterocylic ring together with a nitrogen atom attached thereto;
and n is an integer of 1 to 6.
##STR00008##
[0459] For example, a 4-chloroquinoline derivative can be
synthesized by a conventional method as described, for example, in
Org. Synth. Col. Vol. 3, 272 (1955), Acta Chim. Hung., 112, 241
(1983), or WO 98/47873. Scheme 1 shows an example of the synthesis
of the 4-chloroquinoline derivative. A quinolone derivative is
produced by reacting a 2-aminoacetophenone derivative with a formic
ester, for example, ethyl formate, in a suitable solvent, for
example, tetrahydrofuran, in the presence of a base, for example,
sodium methoxide. The 4-chloroquinoline derivative is produced by
reacting the quinolone derivative in the presence of a chlorinating
agent, for example, phosphorus oxychloride.
[0460] For example, a 4-chloroquinazoline derivative may be
produced as follows. A quinazolone derivative is produced by
reacting a 2-aminobenzoic acid derivative with formamide in a
suitable solvent, for example, a mixed solvent composed of
N,N-dimethylformamide and methanol, in the presence of a base, for
example, sodium methoxide. The 4-chloroquinazoline derivative is
produced by reacting the quinazolone derivative in the presence of
a chlorinating agent, for example, phosphorus oxychloride.
[0461] Next, a 4-(aminophenoxy)quinoline derivative or a
corresponding quinazoline derivative is produced by reacting a
nitrophenol derivative with the 4-chloroquinoline derivative or
corresponding quinazoline derivative in a suitable solvent, for
example, chlorobenzene, to synthesize a 4-(nitrophenoxy)quinoline
derivative or a corresponding quinazoline derivative and then
reacting the 4-(nitrophenoxy)quinoline derivative or corresponding
quinazoline derivative in a suitable solvent, for example,
N,N-dimethyl formamide, in the presence of a catalyst, for example,
palladium hydroxide-carbon, palladium-carbon, under a hydrogen
atmosphere. The nitro group can also be reduced with zinc, iron or
the like.
[0462] Alternatively, the 4-(aminophenoxy)quinoline derivative or
corresponding quinazoline derivative may be produced by reacting an
aminophenol derivative with the 4-chloroquinoline derivative or
corresponding quinazoline derivative in a suitable solvent, for
example, dimethyl sulfoxide, in the presence of a base, for
example, sodium hydride. Alternatively, the
4-(aminophenoxy)quinazoline derivative may also be produced by
dissolving an aminophenol derivative in an aqueous sodium hydroxide
solution and subjecting the solution to a two-phase reaction with a
solution of the 4-chloroquinazoline derivative in a suitable
organic solvent, for example, ethyl methyl ketone, in the presence
of a phase transfer catalyst, for example, tetra-n-butylammonium
chloride, or in the absence of the catalyst.
##STR00009##
[0463] A carbonylthiourea derivative is produced by reacting a
4-(aminophenoxy)quinoline derivative or a quinazoline derivative
with a carbonyl thioisocyanate derivative in a suitable solvent,
for example, a mixed solvent composed of toluene and ethanol. The
carbonyl thioisocyanate derivative is commercially available or can
be easily produced by a conventional method. For example, the
carbonyl thioisocyanate derivative is produced by reacting an acid
chloride derivative with potassium thiocyanate in a suitable
solvent, for example, acetonitrile.
[0464] A carbonylurea derivative is produced by reacting a
4-(aminophenoxy)quinoline derivative or a quinazoline derivative
with a carbonyl isocyanate derivative in a suitable solvent, for
example, N,N-dimethylformamide. The carbonyl isocyanate derivative
is commercially available or can be easily produced by a
conventional method. For example, as described in J. Org. Chem.,
30, 4306 (1965), the carbonyl isocyanate derivative is produced by
reacting an amide derivative with oxalyl chloride in a suitable
solvent, for example, 1,2-dichloroethane.
[0465] An aminocarbonylurea derivative is produced by reacting a
4-(aminophenoxy)quinoline derivative or a quinazoline derivative
with N-(chlorocarbonyl) isocyanate in a suitable solvent, for
example, dichloromethane, in the presence of a base, for example,
diisopropylamine and then reacting the product with an amine
derivative.
[0466] An amide derivative is produced by reacting a
4-(aminophenoxy)quinoline derivative or a quinazoline derivative
with a carboxylic acid derivative or a metal salt thereof in a
suitable solvent, for example, in chloroform, in the presence of a
condensing agent, for example,
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and a
carboxylic acid activating agent, for example,
1-hydroxybenzotriazole monohydrate.
##STR00010##
[0467] For example, a derivative having a specific substituent at
the 7-position of the quinoline ring can be produced according to
scheme 3. A nitro group can be introduced by protecting a
commercially available 4'-hydroxyacetophenone derivative with a
suitable substituent, for example, benzyl, and then reacting the
protected 4'-hydroxyacetophenone derivative with a nitrating agent,
for example, fuming nitric acid-acetic acid. The later steps are
carried out as shown in scheme 1. Specifically, the nitro group is
reduced to an amino group which is then reacted with a formic ester
in the presence of a base to give a quinolone ring. Next, the
quinolone ring is reacted with a chlorinating agent to give a
4-chloroquinoline derivative. In the chlorination reaction, when
phosphorus oxychloride is used as the chlorinating agent, the yield
can be improved by adding a base, for example,
N,N-diisopropylethylamine. Next, a 4-(aminophenoxy)quinoline
derivative is produced by reacting the nitrophenol derivative with
a 4-chloroquinoline derivative to synthesize a
4-(nitrophenoxy)quinoline derivative which is then reacted in a
suitable solvent in a hydrogen atmosphere in the presence of a
catalyst. The nitro group can also be reduced with zinc, iron or
the like. Alternatively, the 4-(aminophenoxy)quinoline derivative
may be produced by reacting an aminophenol derivative with a
4-chloroquinoline derivative in the presence of a base.
##STR00011##
[0468] For example, a derivative having a specific substituent at
the 7-position of the quinazoline ring can be produced according to
scheme 4. A nitro group can be introduced by protecting a hydroxyl
group in a commercially available 4'-hydroxybezoic acid ester
derivative with a suitable substituent, for example, benzyl, and
then reacting the product with a nitrating agent, for example,
fuming nitric acid-acetic acid. Later steps are carried out as
shown in scheme 1. Specifically, a quinazolone ring is formed by
reducing the nitro group to an amino group and then reacting the
product with formamide in the presence of a base. Next, a
4-chloroquinazoline derivative can be produced by reacting the
product with a chlorinating agent. In the chlorination reaction,
when phosphorus oxychloride is used as a chlorinating agent, the
addition of a base, for example, N,N-diisopropylethylamine can
improve the yield. Next, a 4-(aminophenoxy)quinazoline derivative
is produced by reacting the nitrophenol derivative with a
4-chloroquinazoline derivative to synthesize a
4-(nitrophenoxy)quinazoline derivative which is then reacted in a
suitable solvent in a hydrogen atmosphere in the presence of a
catalyst. The nitro group can also be reduced with zinc, iron or
the like. The 4-(aminophenoxy)quinazoline derivative may also be
produced by reacting an aminophenol derivative with a
4-chloroquinazoline derivative in the presence of a base.
Alternatively, the 4-(aminophenoxy)quinazoline derivative may be
produced by dissolving an aminophenol derivative in an aqueous
sodium hydroxide solution and subjecting the solution to a
two-phase reaction with a solution of the 4-chloroquinazoline
derivative in an organic solvent in the presence of a phase
transfer catalyst or in the absence of the catalyst.
##STR00012##
[0469] For example, a carbonylthiourea derivative having a specific
substituent at the 7-position of the quinoline or quinazoline ring
can be produced according to scheme 5. Specifically, a
7-hydroxyquinoline derivative or a corresponding
7-hydroxyquinazoline derivative is produced by removing the
protective group of the hydroxyl group in the
4-(nitrophenoxy)quinoline derivative or quinazoline derivative
produced in scheme 3 or 4 under suitable conditions. For example,
when the protective group is benzyl, for example, the deprotection
reaction is carried out in N,N-dimethylformamide in a hydrogen
atmosphere in the presence of palladium hydroxide-carbon or
palladium-carbon. Next, a 4-(aminophenoxy)quinoline derivative or a
corresponding quinazoline derivative is produced by alkylating the
7-hydroxyquinoline derivative or corresponding 7-hydroxyquinazoline
derivative under suitable conditions, for example, by reacting the
7-hydroxyquinoline derivative or corresponding 7-hydroxyquinazoline
derivative with an alkyl halide in a suitable solvent in the
presence of a base and then reacting the alkylation product in a
suitable solvent, for example, N,N-dimethylformamide, in a hydrogen
atmosphere in the presence of a catalyst, for example, palladium
hydroxide-carbon or palladium-carbon. The nitro group can also be
reduced with zinc, iron or the like. Later steps are carried out as
shown in scheme 2. Specifically, a carbonylthiourea derivative is
produced by reacting the 4-(aminophenoxy)quinoline derivative or
the quinazoline derivative with a carbonylthio isocyanate
derivative in a suitable solvent.
##STR00013##
[0470] For example, a carbonylurea derivative having a specific
substituent at the 7-position of the quinoline or quinazoline ring
can be produced according to scheme 6. Specifically, the
4-(aminophenoxy)quinoline derivative or corresponding quinazoline
derivative, of which the 7-position has been alkylated in scheme 5,
is reacted as shown in scheme 2. More specifically, a carbonylurea
derivative is produced by reacting the 4-(aminophenoxy)quinoline
derivative or quinazoline derivative with a carbonyl isocyanate
derivative in a suitable solvent. The carbonylurea derivative
having a specific substituent at the 7-position of the quinoline or
quinazoline ring can also be synthesized by other methods. At the
outset, the 4-(aminophenoxy)quinoline derivative or quinazoline
derivative produced in scheme 3 or 4 is reacted as shown in scheme
2. Specifically, a carbonylurea derivative is produced by reacting
the 4-(aminophenoxy)quinoline derivative or the quinazoline
derivative with a carbonyl isocyanate derivative in a suitable
solvent. A 7-hydroxyquinoline derivative or a corresponding
7-hydroxyquinazoline derivative is produced by removing the
protective group of the hydroxyl group in the carbonylurea
derivative under suitable conditions. For example, when the
protective group is benzyl, for example, the deprotection reaction
is carried out in a hydrogen atmosphere in N,N-dimethylformamide in
the presence of palladium hydroxide-carbon or palladium-carbon.
Next, a carbonylurea derivative having a specific substituent at
the 7-position of the quinoline or quinazoline ring is produced by
alkylating the 7-hydroxyquinoline derivative or corresponding
7-hydroxyquinazoline derivative under suitable conditions, for
example, by reacting the 7-hydroxyquinoline derivative or
corresponding 7-hydroxyquinazoline derivative with an alkyl halide
in a suitable solvent in the presence of a base.
##STR00014##
[0471] For example, an aminocarbonylurea derivative having a
specific substituent at the 7-position of the quinoline or
quinazoline ring can be produced according to scheme 7.
Specifically, the 4-(aminophenoxy)quinoline derivative or
corresponding quinazoline derivative, of which the 7-position has
been alkylated, prepared in scheme 5 is reacted as shown in scheme
2. That is, an aminocarbonylurea derivative is produced by reacting
the 4-(aminophenoxy)quinoline derivative or the quinazoline
derivative with N-(chlorocarbonyl)isocyanate in a suitable solvent
in the presence of a base and then reacting the product with an
amine derivative. The aminocarbonylurea derivative having a
specific substituent at the 7-position of the quinoline or
quinazoline ring can also be synthesized by other methods. At the
outset, the 4-(aminophenoxy)quinoline derivative or quinazoline
derivative produced in scheme 3 or 4 is reacted as shown in scheme
2. Specifically, an aminocarbonylurea derivative is produced by
reacting the 4-(aminophenoxy)quinoline derivative or the
quinazoline derivative with N-(chlorocarbonyl)isocyanate in a
suitable solvent in the presence of a base and then reacting the
product with an amine derivative. A 7-hydroxyquinoline derivative
or a corresponding 7-hydroxyquinazoline derivative is produced by
removing the protective group of the hydroxyl group in the
aminocarbonylurea derivative under suitable conditions. For
example, when the protective group is benzyl, the deprotection
reaction is carried out, for example, in N,N-dimethylformamide, in
a hydrogen atmosphere in the presence of palladium hydroxide-carbon
or palladium-carbon. Next, an aminocarbonylurea derivative having a
specific substituent at the 7-position of the quinoline or
quinazoline ring is produced by alkylating the 7-hydroxyquinoline
derivative or corresponding 7-hydroxyquinazoline derivative under
suitable conditions, for example, with an alkyl halide in a
suitable solvent in the presence of a base.
##STR00015##
[0472] For example, an amide derivative having a specific
substituent at the 7-position of the quinoline or quinazoline ring
can be produced according to scheme 8. Specifically, the
4-(aminophenoxy)quinoline derivative or corresponding quinazoline
derivative, of which the 7-position has been alkylated, prepared in
scheme 5 is reacted as shown in scheme 2. That is, an amide
derivative is produced by reacting the 4-(aminophenoxy)quinoline
derivative or the quinazoline derivative with a carboxylic acid
derivative or a metal salt thereof in a suitable solvent in the
presence of a condensing agent and a carboxylic acid activating
agent. The amide derivative having a specific substituent at the
7-position of the quinoline or quinazoline ring can also be
synthesized by other methods. At the outset, the
4-(aminophenoxy)quinoline derivative or the quinazoline derivative
produced in scheme 3 or 4 is reacted as shown in scheme 2. That is,
an amide derivative is produced by reacting the
4-(aminophenoxy)quinoline derivative or the quinazoline derivative
with a carboxylic acid derivative or a metal salt thereof in a
suitable solvent in the presence of a condensing agent and a
carboxylic acid activating agent. A 7-hydroxyquinoline derivative
or a corresponding 7-hydroxyquinazoline derivative is produced by
removing the protective group of the hydroxyl group in the amide
derivative under suitable conditions. For example, when the
protective group is benzyl, the deprotection reaction is carried
out, for example, in N,N-dimethylformamide, in a hydrogen
atmosphere in the presence of palladium hydroxide-carbon or
palladium-carbon. Next, an amide derivative having a specific
substituent at the 7-position of the quinoline or quinazoline ring
is produced by alkylating the 7-hydroxyquinoline derivative or
corresponding 7-hydroxyquinazoline derivative under suitable
conditions, for example, by reacting the 7-hydroxyquinoline
derivative or corresponding 7-hydroxyquinazoline derivative with an
alkyl halide in a suitable solvent in the presence of a base.
##STR00016## ##STR00017##
[0473] For example, a carbonylurea derivative and carbonylthiourea
derivative having a specific substituent at the 7-position of the
quinoline or quinazoline ring can be produced according to scheme
9. Specifically, a carbonylurea derivative or a carbonylthiourea
derivative can be produced by deprotecting the
4-aminophenoxyquinoline derivative or corresponding quinazoline
derivative, of which the 7-position has been protected by benzyl,
under acidic conditions to give a phenol compound, then reacting
the phenol compound with an alkyl halide in a suitable solvent in
the presence of a base to give a corresponding ether compound, and
then reacting the product with a suitable amine in a suitable
solvent in the presence of a base to give a corresponding
7-amino-substituted (4-aminophenoxy)quinoline derivative and then
reacting this derivative with a carbonyl isocyanate derivative or a
carbonylisothiocyanate derivative. Alternatively, a corresponding
carbonylthiourea derivative having a specific substituent at the
7-position can be produced by reacting the ether compound, provided
after the reaction with the alkyl halide, with a
carbonylisothiocyanate derivative to give a carbonylthiourea
derivative and then reacting the carbonylthiourea derivative with a
suitable amine in a suitable solvent in the presence of a base.
[0474] Use of Compounds/Pharmaceutical Composition
[0475] The compounds according to the present invention have tumor
growth inhibitory activity in vivo (see Pharmacological Test
Examples 3, 4, and 5).
[0476] Further, the compounds according to the present invention
inhibit in vitro the met autophosphorylation caused by the
stimulation of human epidermal cancer cells A431 with HGF and the
met autophosphorylation which constantly occurs in gastric cancer
cells MKN45 non-dependently upon HGF (see Pharmacological Test
Examples 1 and 2).
[0477] Upon HGF stimulation or in a HGF-non-dependent manner for
certain cancer cells, met accelerates proliferation and motility in
various cell species through the autophosphorylation of
intracellular region with tyrosine kinase (J. Biochem., 119, 591,
(1996), Jpn. J. Cancer Res., 88, 564, (1997), and Int. J. Cancer,
78, 750, (1998)). In particular, in a plurality of cancers, for
example, the increasing of HGF concentration in the blood,
excessive development of met, and the development of met mutants
which have acquired HGF non-dependency are reported. met signals
are considered to be involved in the proliferation and invasion of
various cancer cells and metastasis (Int. J. Cancer, 55, 72,
(1993), Oncology Reports, 5, 1013 (1998), Proc. Natl. Acad. Sci.
USA, 88, 4892, (1991), and Cancer, 88, 1801, (2000)). Further, it
is also reported that HGF accelerates through met the proliferation
and migration activity of vascular endothelial cells and
accelerates angiogenesis (Circulation, 97, 381 (1998) and Clinical
Cancer Res., 5, 3695, (1999)), and, consequently, it is estimated
that HGF is also related to angiogenesis in cancers.
[0478] Accordingly, the compounds according to the present
invention can inhibit the growth, invasion, metastasis, and
angiogenesis of cancer cells and thus can be used in the treatment
of malignant tumors.
[0479] According to the present invention, there is provided a
pharmaceutical composition comprising the compound according to the
present invention. The pharmaceutical composition according to the
present invention can be used in the treatment of malignant tumors
such as brain tumors, gastric cancer, colon cancer, pancreatic
cancer, lung cancer, renal cancer, ovarian cancer, and prostate
cancer.
[0480] Further, according to the present invention, there is
provided a method for treating a malignant tumor, comprising the
step of administering a therapeutically effective amount of the
compound according to the present invention together with a
pharmaceutically acceptable carrier to a mammal including a
human.
[0481] Furthermore, according to the present invention, there is
provided use of the compound according to the present invention,
for the manufacture of a medicament for use in the treatment of a
malignant tumor.
[0482] The compounds according to the present invention can be
administered to human and non-human animals orally or parenterally
by administration routes, for example, intravenous administration,
intramuscular administration, subcutaneous administration, rectal
administration, or percutaneous administration. Therefore, the
pharmaceutical composition comprising as an active ingredient the
compound according to the present invention is formulated into
suitable dosage forms according to the administration routes.
Specifically, oral preparations include tablets, capsules, powders,
granules, and syrups, and parental preparations include injections,
suppositories, tapes, and ointments.
[0483] These various preparations may be prepared by conventional
methods, for example, with commonly used excipients, disintegrants,
binders, lubricants, colorants, and diluents.
[0484] Excipients include, for example, lactose, glucose, corn
starch, sorbit, and crystalline cellulose. Disintegrants include,
for example, starch, sodium alginate, gelatin powder, calcium
carbonate, calcium citrate, and dextrin. Binders include, for
example, dimethylcellulose, polyvinyl alcohol, polyvinyl ether,
methylcellulose, ethylcellulose, gum arabic, gelatin,
hydroxypropylcellulose, and polyvinyl pyrrolidone. Lubricants
include, for example, talc, magnesium stearate, polyethylene
glycol, and hydrogenated vegetable oils.
[0485] In preparing the injections, if necessary, for example,
buffers, pH adjustors, stabilizers, tonicity agents, and
preservatives may be added.
[0486] The content of the compound according to the present
invention in the pharmaceutical composition according to the
present invention may vary depending upon the dosage form. In
general, however, the content is 0.5 to 50% by weight, preferably 1
to 20% by weight, based on the whole composition.
[0487] The dose may be appropriately determined in consideration
of, for example, the age, weight, sex, difference in diseases, and
severity of condition of individual patients, preferably in the
range of 1 to 100 mg/kg. This dose is administered at a time daily
or divided doses of several times daily.
[0488] The compound according to the present invention may be
administered in combination with other medicament, for example, a
carcinostatic agent. In this case, the compound according to the
present invention may be administered simultaneously with or after
or before the administration of other medicament. The type,
administration intervals and the like of the carcinostatic agent
may be determined depending upon the type of cancer and the
condition of patients.
EXAMPLES
[0489] The present invention is further illustrated by Examples
that are not intended as a limitation of the invention.
[0490] Starting compounds necessary for synthesis were produced as
described in WO 97/17329, WO 98/47873, WO 00/43366, and Japanese
Patent Laid-Open Publication No. 328782/1997. Starting compounds
not described in these publications were produced as described in
Production Examples below.
##STR00018## ##STR00019## ##STR00020##
##STR00021##
Production Example 1
Starting compound 1
[0491] 7-(Benzyloxy)-4-chloro-6-methoxyquinoline (29 g),
3-fluoro-4-nitrophenol (20 g), N,N-diisopropylethylamine (33 ml),
and chlorobenzene (14 ml) were added, and the mixture was stirred
with heating at 140.degree. C. for 15 hr. After the completion of
the reaction, a 2 N aqueous sodium hydroxide solution (30 ml) was
added thereto, and the mixture was stirred at room temperature for
3 hr. Water was added to the reaction solution, and the mixture was
extracted with chloroform. The chloroform layer was dried over
anhydrous sodium sulfate. The solvent was removed by evaporation
under the reduced pressure to give the target compound (40 g, yield
50%).
[0492] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 8.58 (d, J=5.1
Hz, 1H), 8.48-8.44 (m, 1H), 8.21-8.19 (m, 1H), 7.64-7.35 (m, 8H),
6.79 (d, J=5.1 Hz, 1H), 5.33 (s, 2H), 3.94 (s, 3H)
[0493] Mass spectrometric value (m/z): 421 [M+H].sup.+
Production Example 2
Starting Compound 2
[0494] 7-(Benzyloxy)-4-(3-fluoro-4-nitrophenoxy)-6-methoxyquinoline
(35 g), zinc (74 g), and ammonium chloride (14 g) were added to
ethanol/water (20/1, 525 ml), and the mixture was stirred with
heating at 120.degree. C. for 18 hr. After the completion of the
reaction, the reaction solution was filtered through Celite. The
filtrate was concentrated, and the concentrate was washed with
water to give the target compound (32 g, yield 94%).
[0495] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 8.58 (d, J=5.1
Hz, 1H), 8.48-8.44 (m, 1H), 8.24 (m, 2H), 7.64-7.38 (m, 9H), 6.75
(d, J=5.1 Hz, 1H), 5.31 (s, 2H), 3.94 (s, 3H)
[0496] Mass spectrometric value (m/z): 391 [M+H].sup.+
Production Example 3
Starting Compound 3
[0497] 4-Fluorophenylacetamide (78 mg, see Example 3 for the
production process thereof) was dissolved in 1,2-dichloroethane (20
ml) to prepare a solution. Oxalyl chloride (56 .mu.l) was then
added to the solution, and the mixture was heated under reflux at
110.degree. C. for 15.5 hr. After the completion of the reaction,
the reaction solution was concentrated under the reduced pressure
to give a crude. Dimethylformamide (10 ml) and
4-{[7-(benzyloxy)-6-methoxy-4-quinolyl]oxy}-2-fluoroaniline (50 mg)
were added to the crude, and the mixture was stirred at room
temperature for 5 hr. After the completion of the reaction, the
reaction solution was concentrated under the reduced pressure to
give a crude which was then purified by chromatography on silica
gel using chloroform/methanol for development to give the target
compound (49 mg, yield 67%).
[0498] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 11.16 (br, 1H),
10.75 (br, 1H), 8.49 (d, J=4.9 Hz, 1H), 8.24-8.19 (m, 1H),
7.53-7.35 (m, 10H), 7.19-7.11 (m, 3H), 6.56 (d, J=5.4 Hz, 1H), 5.31
(s, 2H), 3.94 (s, 3H), 3.75 (s, 2H)
[0499] Mass spectrometric value (m/z): 570 [M+H].sup.+
Production Example 4
Starting Compound 4
[0500]
N-(4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2-fluorophenyl)-N'-[-
2-(4-fluorophenyl)acetyl]urea (1.6 g) and palladium
hydroxide-carbon (1.3 g) were added to dimethylformamide (14 ml),
and the mixture was stirred in a hydrogen atmosphere at room
temperature for 10 hr. After the completion of the reaction, the
reaction solution was filtered through Celite, and the filtrate was
concentrated to give the target compound (1.3 g, yield 98%).
[0501] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 8.39 (m, 2H),
8.21-8.18 (m, 1H), 7.45 (m, 1H), 7.33-7.23 (m, 8H), 7.01 (m, 1H),
6.42 (m, 1H), 6.18 (m, 2H), 3.92 (s, 3H)
[0502] Mass spectrometric value (m/z): 480 [M+H].sup.+
Production Example 5
Starting Compound 5
[0503] 7-(Benzyloxy)-4-chloro-6-methoxyquinoline (81 g),
2-fluoro-4-nitrophenol (51 g), N,N-diisopropylethylamine (94 ml),
and chlorobenzene (40 ml) were added, and the mixture was stirred
with heating at 140.degree. C. for 18 hr. After the completion of
the reaction, a 2 N aqueous sodium hydroxide solution (40 ml) was
added thereto, and the mixture was stirred at room temperature for
3 hr. Water was added to the reaction solution, and the mixture was
extracted with chloroform. The chloroform layer was dried over
anhydrous sodium sulfate. The solvent was removed by evaporation
under the reduced pressure to give the target compound (100 g,
yield 92%).
[0504] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 8.45 (d, J=5.4
Hz, 1H), 7.53-7.34 (m, 7H), 7.07-7.03 (m, 1H), 6.89-6.82 (m, 2H),
6.43 (d, J=5.4 Hz, 1H), 5.29 (s, 2H), 3.94 (s, 3H)
[0505] Mass spectrometric value (m/z): 421 [M+H].sup.+
Production Example 6
Starting Compound 6
[0506] 7-(Benzyloxy)-4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinoline
(36 g), zinc (74 g), and ammonium chloride (14 g) were added to
ethanol/water (20/1, 525 ml), and the mixture was stirred with
heating at 120.degree. C. for 19 hr. After the completion of the
reaction, the reaction solution was filtered through Celite. The
filtrate was concentrated, and the concentrate was washed with
water to give the target compound (35 g, yield 96%).
[0507] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 8.57 (d, J=5.1
Hz, 1H), 8.44-8.37 (m, 1H), 8.22 (m, 2H), 7.65-7.38 (m, 9H), 6.78
(d, J=5.1 Hz, 1H), 5.33 (s, 2H), 3.96 (s, 3H)
[0508] Mass spectrometric value (m/z): 391 [M+H].sup.+
Production Example 7
Starting Compound 7
[0509] 4-Fluorophenylacetamide (86 mg, see Example 3 for the
production process thereof) was dissolved in 1,2-dichloroethane
(200 ml) at 80.degree. C. to prepare a solution. Oxalyl chloride
(150 .mu.l) was added to the solution, and the mixture was stirred
at 80.degree. C. for 10 hr. After the completion of the reaction,
the reaction solution was concentrated under the reduced pressure
to give a crude. Dimethylformamide (2 ml) and
4-{[7-(benzyloxy)-6-methoxy-4-quinolyl]oxy}-3-fluoroaniline (170
mg) were added to the crude, and the mixture was stirred at room
temperature for 3 hr. After the completion of the reaction, the
reaction solution was concentrated under the reduced pressure to
give 248 mg of the target compound.
[0510] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 8.46 (d, J=5.1
Hz, 1H), 7.50-6.85 (m, 16H), 6.44 (d, J=5.2 Hz, 1H), 5.31 (s, 2H),
3.93 (s, 3H), 3.74 (s, 2H)
[0511] Mass spectrometric value (m/z): 570 [M+H].sup.+
Production Example 8
Starting Compound 8
[0512]
N-(4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-3-fluorophenyl)-N'-[-
2-(4-fluorophenyl)acetyl]urea (1.5 g) and palladium
hydroxide-carbon (1.1 g) were added to dimethylformamide (20 ml),
and the mixture was stirred in a hydrogen atmosphere at room
temperature for 10 hr. After the completion of the reaction, the
reaction solution was filtered through Celite. The filtrate was
concentrated to give the target compound (1.1 g, yield 88%).
[0513] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 8.51 (d, J=5.2
Hz, 1H), 7.89-7.70 (m, 1H), 7.51-7.07 (m, 11H), 6.31 (d, J=5.1 Hz,
1H), 3.94 (s, 3H), 3.74 (s, 2H)
[0514] Mass spectrometric value (m/z): 480 [M+H].sup.+
Production Example 9
Starting Compound 9
[0515] 2-Phenylacetamide (76 mg) was dissolved in
1,2-dichloroethane (200 ml) at 80.degree. C. to prepare a solution.
Oxalyl chloride (150 .mu.l) was added to the solution, and the
mixture was stirred at 80.degree. C. for 10 hr. After the
completion of the reaction, the reaction solution was concentrated
under the reduced pressure to give a crude. Dimethylformamide (2
ml) and 4-{[7-(benzyloxy)-6-methoxy-4-quinolyl]oxy}-3-fluoroaniline
(170 mg) were added to the crude which was then stirred at room
temperature for 3 hr. After the completion of the reaction, the
reaction solution was concentrated under the reduced pressure to
give 228 mg of the target compound.
[0516] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 8.43 (d, J=5.3
Hz, 1H), 7.55-7.19 (m, 17H), 6.42 (d, J=5.4 Hz, 1H), 5.31 (s, 2H),
3.95 (s, 3H), 3.75 (s, 2H)
[0517] Mass spectrometric value (m/z): 552 [M+H].sup.+
Production Example 10
Starting Compound 10
[0518]
N-(4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-3-fluorophenyl)-N'-(-
2-phenylacetyl)urea (1.2 g) and palladium hydroxide-carbon (1.0 g)
were added to dimethylformamide (20 ml), and the mixture was
stirred in a hydrogen atmosphere at room temperature for 10 hr.
After the completion of the reaction, the reaction solution was
filtered through Celite. The filtrate was concentrated to give the
target compound (0.85 g, yield 85%).
[0519] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 8.43 (d, J=5.1
Hz, 1H), 7.82-7.79 (m, 1H), 7.49-7.08 (m, 12H), 6.36 (d, J=5.1 Hz,
1H), 3.95 (s, 3H), 3.75 (s, 2H)
[0520] Mass spectrometric value (m/z): 462 [M+H].sup.+
Production Example 11
Starting Compound 11
[0521]
3-Fluoro-4-[(7-benzyloxy-6-methoxy-4-quinolyl)oxy]-nitrobenzene
(2.5 g), together with trifluoroacetic acid (15 ml) and
methanesulfonic acid (0.7 ml), was heated under reflux for one hr.
The solvent was removed by evaporation, and the residue was then
neutralized with a 10% aqueous sodium hydroxide solution. The
precipitated crystal was collected by suction filtration to give a
crude crystal (1.95 g). The crude crystal was dissolved in
dimethylformamide (50 ml) without purification. Potassium carbonate
(4.3 g) and 1-bromo-3-chloropropane (4.9 g) were added to the
solution, and the mixture was stirred at room temperature for 16
hr. The reaction solution was extracted with ethyl acetate,
followed by washing with saturated brine. The extract was then
dried over anhydrous sodium sulfate. The solvent was removed by
evaporation under the reduced pressure to give a crude which was
then washed with an ethyl acetate/hexane (1/1) mixed solution to
give the target compound (1.76 g, yield 73%).
[0522] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.35-2.41 (m,
2H), 3.80 (t, J=6.3 Hz, 2H), 3.99 (s, 3H), 4.34 (t, J=6.3 Hz, 2H),
6.53 (d, J=5.1 Hz, 1H), 7.27-7.34 (m, 1H), 7.42 (s, 1H), 7.46 (s,
1H), 8.10-8.18 (m, 2H), 8.56 (d, J=5.1 Hz, 1H)
Production Example 12
Starting Compound 12
[0523]
3-Fluoro-4-{[7-(3-chloropropyl)-6-methoxy-4-quinolyl]oxy}nitrobenze-
ne (500 mg) was dissolved in dimethylformamide (20 ml) to prepare a
solution. Potassium carbonate (890 mg), sodium iodide (290 mg), and
morpholine (645 mg) were added to the solution, and the mixture was
stirred at 70.degree. C. for 18 hr. The mixture was extracted with
ethyl acetate, followed by washing with saturated brine. The
extract was dried over anhydrous sodium sulfate. The solvent was
removed by evaporation under the reduced pressure to give a crude.
The crude was dissolved in methanol (30 ml) without purification.
Ammonium chloride (207 mg) and zinc (1.26 g) were added to the
solution, and the mixture was heated under reflux for 5 hr. Zinc
was removed by filtration. Chloroform was added to the filtrate,
the mixture was washed with a saturated sodium hydrogencarbonate
solution, and the solvent was then removed by evaporation under the
reduced pressure to give a crude. The crude was purified by column
chromatography on silica gel using chloroform/methanol for
development to give the target compound (440 mg, yield 80%).
[0524] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.02-2.11 (m,
2H), 2.35-2.47 (m, 4H), 2.50 (t, J=6.3 Hz, 2H), 3.61-3.69 (m, 4H),
3.75 (s, 2H), 3.96 (s, 3H), 4.20 (t, J=6.6 Hz, 2H), 6.33 (d, J=5.4
Hz, 1H), 6.41-6.51 (m, 2H), 6.96 (t, J=8.5 Hz, 1H), 7.35 (s, 1H),
7.51 (s, 1H), 8.39 (d, J=5.4 Hz, 1H)
Example 1
[0525] Phenylacetyl chloride [starting compound B] (1.89 ml) and
potassium thiocyanate (2.09 g) were dissolved in acetonitrile (15
ml) to prepare a solution, and the solution was then stirred at
80.degree. C. for one hr. Water was added to the reaction solution,
the mixture was extracted with chloroform, and chloroform was then
removed by evaporation under the reduced pressure to give a crude.
The crude was dissolved in toluene/ethanol (1/1).
4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluoroaniline [starting
compound A] (3.03 g) was added to the solution, and the mixture was
stirred at room temperature overnight. The reaction solvent was
removed by evaporation under the reduced pressure. The residue was
purified by chromatography on silica gel using chloroform/acetone
for development to give the title compound (0.69 g, yield
14.5%.
[0526] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 3.76 (s, 2H),
4.05 (s, 3H), 4.06 (s, 3H), 6.46 (d, J=4.4 Hz, 1H), 7.23-7.34 (m,
3H), 7.38-7.48 (m, 5H), 7.56 (s, 1H), 7.93 (m, 1H), 8.48 (br, 1H),
8.51 (d, J=5.4 Hz, 1H), 12.47 (br, 1H)
[0527] Mass spectrometric value (m/z): 492 [M+H].sup.+
Example 2
[0528] Thionyl chloride (348 .mu.l) was added to
4-fluorophenylacetic acid [starting compound B] (123 mg), and the
mixture was stirred with heating at 50.degree. C. for one hr. After
the completion of the reaction, the reaction solution was
concentrated under the reduced pressure to give a crude. The crude
was dissolved in acetonitrile (20 ml). Potassium thiocyanate (155
mg) was added to the solution, and the mixture was stirred with
heating at 50.degree. C. for 40 min. Thereafter,
4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoroaniline [starting
compound A] (50 mg) was added thereto, and the mixture was then
further stirred with heating for 60 min. After the completion of
the reaction, the reaction solution was concentrated under the
reduced pressure to give a crude. An aqueous saturated sodium
hydrogencarbonate solution was added to the crude, and the mixture
was extracted with ethyl acetate. The ethyl acetate layer was dried
over anhydrous sodium sulfate and was concentrated under the
reduced pressure. The concentrate was purified by chromatography on
silica gel using chloroform/acetone for development to give the
title compound (61 mg, yield 75%).
[0529] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 3.87 (s, 2H),
4.05 (s, 3H), 4.06 (s, 3H), 6.45 (d, J=5.1 Hz, 1H), 7.12 (m, 2H),
7.23-7.32 (m, 3H), 7.40 (m, 1H), 7.44 (s, 1H), 7.56 (s, 1H), 7.93
(m, 1H), 8.51 (d, J=5.1 Hz, 1H), 8.70 (br, 1H), 12.45 (br, 1H)
[0530] Mass spectrometric value (m/z): 510 [M+H].sup.+
Example 3
[0531] 4-Fluorophenylacetic acid [starting compound B] (15 g) was
dissolved in thionyl chloride (15 ml) to prepare a solution which
was then heated at 60.degree. C. for one hr. Excess thionyl
chloride was removed by evaporation under the reduced pressure to
give 4-fluorophenylacetyl chloride. The acid chloride was dissolved
in acetone (200 ml). Ammonium acetate (112 g) was added to the
solution, and the mixture was stirred at room temperature for 17
hr. An aqueous saturated sodium hydrogencarbonate solution (150 ml)
was added thereto, and the mixture was stirred at room temperature
for one hr. The reaction solution was then extracted with
chloroform, and the solvent in the extract was removed by
evaporation to give a crude crystal. The resultant crude crystal
was washed with a hexane/ethyl acetate (2/1) mixed solution to give
4-fluorophenylacetamide (10.5 g, yield 70%).
[0532] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 3.53 (s, 2H),
5.25-5.70 (m, 2H), 7.00-7.05 (m, 2H), 7.20-7.26 (m, 2H)
[0533] 4-Fluorophenylacetamide (2.05 g) was dissolved in
1,2-dichloroethane (250 ml) to prepare a solution. Oxalyl chloride
(1.63 ml) was then added to the solution, and the mixture was
heated for 15.5 hr under reflux. The solvent was removed by
evaporation under the reduced pressure to give a crude. The crude
was then dissolved in dimethylformamide (50 ml) to prepare a
solution which was then added at room temperature to a previously
prepared solution of
4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluoroaniline [starting
compound A] (2.10 g) in dimethylformamide (30 ml). The mixture was
stirred at that temperature for 5 hr. The solvent was removed by
evaporation under the reduced pressure to give a crude. The crude
was purified by column chromatography on silica gel using
chloroform/methanol for development. The solvent was removed by
evaporation under the reduced pressure to give a crude compound
which was then washed with methanol to give the title compound
(2.27 g, yield 69%).
[0534] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 3.74 (s, 2H),
4.04 (s, 3H), 4.05 (s, 3H), 6.52 (d, J=5.4 Hz, 1H), 6.99 (m, 2H),
7.10 (m, 2H), 7.30 (m, 2H), 7.45 (s, 1H), 7.49 (s, 1H), 8.17-8.24
(m, 2H), 8.52 (d, J=5.4 Hz, 1H), 10.73 (br, 1H)
[0535] Mass spectrometric value (m/z): 494 [M+H].sup.+
Example 4
[0536] 2-Phenylacetamide [starting compound B] (91 mg) was
dissolved in 1,2-dichloroethane (250 ml) to prepare a solution.
Oxalyl chloride (73 .mu.l) was added to the solution, and the
mixture was heated under reflux at 110.degree. C. for 15.5 hr.
After the completion of the reaction, the reaction solution was
concentrated under the reduced pressure to give a crude.
Dimethylformamide (10 ml) and
4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline [starting compound A] (50
mg) were added to the crude, and the mixture was stirred at room
temperature for 5 hr. After the completion of the reaction, the
reaction solution was concentrated under the reduced pressure to
give a crude. The crude was purified by chromatography on silica
gel using chloroform/methanol for development to give the title
compound (44 mg, yield 57%).
[0537] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 10.96 (s, 1H),
10.52 (s, 1H), 8.45 (d, J=5.1 Hz, 1H), 8.30 (s, 1H), 7.64 (d, J=9.0
Hz, 2H), 7.49 (s, 1H), 7.43-6.84 (m, 7H), 6.44 (d, J=5.4 Hz, 1H),
3.95 (s, 3H), 3.86 (s, 3H), 3.72 (s, 2H)
[0538] Mass spectrometric value (m/z): 458 [M+H].sup.+
Example 5
[0539] 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline [starting compound
A] (5.00 g) was dissolved in chloroform (100 ml) to prepare a
solution. Potassium carbonate (4.66 g) was added to the solution,
and the mixture was stirred at 0.degree. C. Methylmalonyl chloride
[starting compound B] (2.18 ml) was added to the reaction solution,
and the mixture was stirred at room temperature for 60 min. Water
was added to the reaction solution, and the mixture was extracted
with chloroform. The chloroform layer was washed with saturated
brine and was dried over anhydrous sodium sulfate. The dried
chloroform layer was then concentrated under the reduced pressure
to give a crude. The crude was then dissolved in ethanol/water
(10/1, 165 ml). Lithium hydroxide monohydrate (1.42 g) was added to
the solution, and the mixture was stirred at room temperature for 4
hr. The reaction solution was concentrated under the reduced
pressure. Water was then added to the concentrate, and the solution
was made weakly acidic by the addition of hydrochloric acid. The
solution was allowed to stand overnight at 0.degree. C., followed
by filtration to give 6.45 g of a crystal (hereinafter referred to
simply as "carboxylic acid"). The carboxylic acid (30 mg),
1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (30
mg), 1-hydroxybenzotriazole monohydrate (24 mg), and
4-fluoroaniline [starting compound C] (10 mg) were dissolved in
chloroform (3 ml) to prepare a solution which was then stirred at
60.degree. C. overnight. The reaction solution was developed on
diatomaceous earth impregnated with an aqueous saturated sodium
hydrogencarbonate solution, followed by extraction with chloroform.
The solvent in the extract was removed by evaporation to give a
crude. The crude was purified by HPLC using chloroform/methanol for
development to give the title compound (0.7 mg, yield 1.9%).
[0540] .sup.1H-NMR (CDCl.sub.3/CD.sub.3OD, 400 MHz): .delta. 3.49
(s, 2H), 4.05 (s, 3H), 4.06 (s, 3H), 6.46 (d, J=5.1 Hz, 1H),
7.01-7.08 (m, 2H), 7.15-7.19 (m, 2H), 7.41 (s, 1H), 7.52-7.56 (m,
3H), 7.66-7.70 (m, 2H), 8.46 (d, J=5.4 Hz, 1H)
[0541] Mass spectrometric value (m/z): 476 [M+H].sup.+
Example 6
[0542] 2,4-Difluoroaniline [starting compound C] (3.0 g) was
dissolved in chloroform (50 ml) to prepare a solution. Potassium
carbonate (6.24 g) was added to the solution, and the mixture was
stirred. Ethylmalonyl chloride [starting compound B] (4 ml) was
added to the reaction solution, and the mixture was stirred at room
temperature for 10 min. Water was added to the reaction solution,
and the mixture was extracted with chloroform. The chloroform layer
was washed with saturated brine and was dried over anhydrous sodium
sulfate. The dried chloroform layer was concentrated under the
reduced pressure to give 5.12 g of a crude. In ethanol/water (10/1,
33 ml) was dissolved 2.85 g out of 5.12 g of the crude. Lithium
hydroxide monohydrate (0.99 g) was added to the solution, and the
mixture was stirred at room temperature for 4 hr. The reaction
solution was concentrated under the reduced pressure to give 3.76 g
of a crude (hereinafter referred to simply as "carboxylic acid").
Chloroform (3 ml) was added to
3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline [starting
compound A] (32 mg), carboxylic acid (31 mg),
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (28
mg), and 1-hydroxybenzotriazole monohydrate (22 mg), and the
mixture was stirred at 60.degree. C. overnight. The reaction
solution was developed on diatomaceous earth impregnated with an
aqueous saturated sodium hydrogencarbonate solution, followed by
extraction with chloroform. The solvent in the extract was removed
by evaporation to give a crude. The crude was purified by HPLC
using chloroform/methanol for development to give the title
compound (0.1 mg, yield 2.0%).
[0543] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 3.59 (s, 2H),
4.05 (s, 3H), 4.07 (s, 3H), 6.33 (d, J=5.1 Hz, 1H), 6.90-7.33 (m,
4H), 7.45 (s, 1H), 7.52 (s, 1H), 7.58 (s, 1H), 7.90-7.93 (m, 1H),
8.48 (d, J=5.4 Hz, 1H)
[0544] Mass spectrometric value (m/z): 528 [M+H].sup.+
Example 7
[0545] 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline [starting compound
A] (100 mg) was dissolved in chloroform (3 ml) to prepare a
solution. Chloroacetyl isocyanate [starting compound B] (40 mg) was
added to the solution, and the mixture was stirred at room
temperature for 10 hr. The reaction solution was purified by
chromatography on silica gel to give
N-(2-chloroacetyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea
(116 mg, yield 83%). Next,
N-(2-chloroacetyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea
(50 mg) and potassium carbonate (26 mg) were added to chloroform,
and cyclopentanethiol [starting compound C] (38 .mu.l) was added to
the mixture with stirring. The mixture was stirred at room
temperature for 3 hr, and the reaction solution was filtered
through Celite. The filtrate was then concentrated under the
reduced pressure to give a crude. The crude was purified by
chromatography on silica gel using chloroform/methanol for
development to give the title compound (35 mg, yield 60%).
[0546] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 10.84 (br, 1H),
10.49 (br, 1H), 8.48 (d, J=5.1 Hz, 1H), 7.69-7.67 (m, 4H), 7.51 (s,
1H), 7.39 (s, 1H), 7.26-7.24 (d, J=9.0 Hz, 1H), 3.93 (s, 6H), 3.41
(s, 2H), 2.08-1.97 (m, 2H), 1.67-1.42 (m, 7H)
[0547] Mass spectrometric value (m/z): 482 [M+H].sup.+
Example 8
[0548] 3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline [starting
compound A] (100 mg) was dissolved in chloroform (3 ml) to prepare
a solution. Chloroacetyl isocyanate [starting compound B] (42 mg)
was added to the solution, and the mixture was stirred at room
temperature for 10 hr. The reaction solution was purified by
chromatography on silica gel to give
N-(2-chloroacetyl)-N'-{3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phe-
nyl}urea (115 mg, yield 85%). Next,
N-(2-chloroacetyl)-N'-{3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}u-
rea (50 mg) and potassium carbonate (28 mg) were added to
chloroform, and indoline [starting compound C] (36 .mu.l) was added
to the mixture with stirring. The mixture was stirred at room
temperature for 3 hr, and the reaction solution was filtered
through Celite. The filtrate was then concentrated under the
reduced pressure. The concentrate was purified by chromatography on
silica gel using chloroform/methanol for development to give the
title compound (33 mg, yield 56%).
[0549] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 10.64 (br, 1H),
8.46 (d, J=5.6 Hz, 1H), 7.90 (d, J=2.7 Hz, 1H), 7.63 (s, 1H),
7.54-7.51 (m, 2H), 7.34 (s, 1H), 7.22-7.11 (m, 3H), 6.86-6.83 (m,
1H), 6.48 (d, J=7.8 Hz, 1H), 6.42 (d, J=5.6 Hz, 1H), 4.08 (s, 6H),
3.87 (s, 2H), 3.55-3.51 (m, 2H), 3.13-3.09 (m, 2H)
[0550] Mass spectrometric value (m/z): 533 [M+H].sup.+
Example 9
[0551] 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline [starting compound
A] (415 mg) was dissolved in 10 ml of a 1% AcOH/DMF solution to
prepare a solution. Further, aldehyde linker lanthanum (D-series;
28 .mu.mol/unit) (10 units) was added to the solution. The reaction
mixture was slowly shaken for 19 hr. Sodium boron triacetoxyhydride
(475 mg) was added thereto, and the mixture was further slowly
shaken for 24 hr. Lanthanum was taken out of the reaction solution
and was washed with alternate N,N-dimethylformamide and
dichloromethane each three times, followed by drying under the
reduced pressure to give lanthanum with
4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline supported thereon. This
lanthanum (3 units) was added to 1 ml of dichloromethane, and a
solution of N-(chlorocarbonyl)isocyanate [starting compound B] (55
.mu.l) in dichloromethane (0.2 ml) was added to the mixture at
0.degree. C. The mixture was slowly shaken overnight at room
temperature. Further, a mixed solution composed of aniline
[starting compound C] (68 .mu.l), diisopropylamine (0.2 ml), and
dichloromethane (0.3 ml) was then added thereto at 0.degree. C. The
mixture was shaken at room temperature for 7 hr and was then washed
with alternate N,N-dimethylformamide and dichloromethane each five
times. Drying under the reduced pressure was carried out, a 50%
TFA/dichloromethane solution (1 ml) was added thereto, and the
mixture was shaken at room temperature for 50 min to take off the
product from lanthanum, followed by purification by thin layer
chromatography on silica gel to give 6.8 mg of the title
compound.
[0552] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 3.98 (s, 6H),
6.40 (d, J=5.4 Hz, 1H), 7.09 (m, 1H), 7.10 (d, J=9 Hz, 2H), 7.27
(t, J=7.8 Hz, 2H), 7.33 (s, 1H), 7.38 (d, J=7.8 Hz, 2H), 7.47 (s,
1H), 7.48 (d, J=8.5 Hz, 2H), 8.37 (d, J=5.4 Hz, 1H)
[0553] Mass spectrometric value (m/z): 457 [M-H].sup.+
Example 10
[0554] 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline [starting compound
A] (500 mg) was dissolved in 20 ml of dichloromethane to prepare a
solution, and N-(chlorocarbonyl)isocyanate [starting compound B]
(145 .mu.l) was slowly added to the solution. The mixture was
stirred at room temperature for 2.5 hr. 4-Fluoroaniline [starting
compound C] (205 mg) and diisopropylamine (0.35 ml) were then added
thereto at 0.degree. C. Further, the temperature of the reaction
solution was returned to room temperature before stirring for 2.5
hr. Water was added to the reaction solution, and the mixture was
then extracted with chloroform. The chloroform layer was dried over
anhydrous sodium sulfate. The dried chloroform layer was
concentrated under the reduced pressure, and the concentrate was
then purified by chromatography on silica gel to give 380 mg of the
title compound.
[0555] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 4.03 (s, 3H),
4.04 (s, 3H), 6.42 (d, J=5.4 Hz, 1H), 7.00 (m, 2H), 7.14 (d, J=9
Hz, 2H), 7.33 (br, 2H), 7.40 (s, 1H), 7.45 (br, 2H), 7.53 (s, 1H),
8.48 (d, J=5.4 Hz, 1H)
[0556] Mass spectrometric value (m/z): 475 [M-H].sup.+
Example 11
[0557]
N-{3-Fluoro-4-[(7-hydroxy-6-methoxy-4-quinolyl)-oxy]phenyl}-N'-(2-p-
henylacetyl)urea [starting compound A] (100 mg), potassium
carbonate (150 mg), and 1,3-dibromopropane [starting compound C]
(66 .mu.l) were dissolved in dimethylformamide (5 ml) to prepare a
solution which was then stirred at room temperature for 5 hr.
Thereafter, morpholine [starting compound B] (57 .mu.l) was further
added thereto, and the mixture was stirred at room temperature for
3 hr. After the completion of the reaction, the reaction solution
was filtered through Celite, and the filtrate was then concentrated
under the reduced pressure to give a crude. The crude was purified
by thin layer chromatography on silica gel using
chloroform/methanol for development to give the title compound (23
mg, yield 18%).
[0558] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.07 (m, 2H),
2.44 (m, 4H), 2.53 (t, J=7.1 Hz, 2H), 3.66 (m, 4H), 3.69 (s, 2H),
3.96 (s, 3H), 4.20 (t, J=6.6 Hz, 2H), 6.33 (d, J=5.4 Hz, 1H),
7.11-7.45 (m, 8H), 7.49 (s, 1H), 7.61 (m, 1H), 8.01 (br, 1H), 8.41
(d, J=5.4 Hz, 1H), 10.59 (br, 1H)
[0559] Mass spectrometric value (m/z): 589 [M+H].sup.+
Example 12
[0560]
N-{3-Fluoro-4-[(7-hydroxy-6-methoxy-4-quinolyl)-oxy]phenyl}-N'-(2-p-
henylacetyl)urea [starting compound A] (100 mg), potassium
carbonate (150 mg), and 1,4-dibromobutane [starting compound C] (78
.mu.l) were dissolved in dimethylformamide (5 ml) to prepare a
solution which was then stirred at room temperature for 5 hr.
Thereafter, 1-methylpiperazine [starting compound B] (72 .mu.l) was
further added thereto, and the mixture was stirred at room
temperature for 3 hr. After the completion of the reaction, the
reaction solution was filtered through Celite, and the filtrate was
then concentrated under the reduced pressure to give a crude. The
crude was purified by thin layer chromatography on silica gel using
chloroform/methanol for development to give the title compound (24
mg, yield 18%).
[0561] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 11.07 (br, 1H),
10.70 (br, 1H), 8.76 (d, J=6.3 Hz, 1H), 7.88 (d, J=11.7 Hz, 1H),
7.70 (s, 1H), 7.55 (s, 1H), 7.53-7.49 (m, 3H), 7.34-7.27 (m, 4H),
6.86 (br, 1H), 4.28-4.26 (m, 2H), 4.01 (s, 4H), 3.74 (s, 3H),
3.65-3.63 (m, 1H), 3.28-3.16 (m, 3H), 2.99-2.49 (m, 3H), 2.31-1.89
(m, 8H)
[0562] Mass spectrometric value (m/z): 616 [M+H].sup.+
Example 13
[0563]
N-{3-Fluoro-4-[(7-hydroxy-6-methoxy-4-quinolyl)-oxy]phenyl}-N'-(2-p-
henylacetyl)urea [starting compound A] (100 mg), potassium
carbonate (150 mg), and 1,2-dibromoethane [starting compound C] (54
.mu.l) were dissolved in dimethylformamide (5 ml) to prepare a
solution which was then stirred at room temperature for 5 hr.
Thereafter, piperidine [starting compound B] (64 .mu.l) was further
added thereto, and the mixture was stirred at room temperature for
3 hr. After the completion of the reaction, the reaction solution
was filtered through Celite, and the filtrate was then concentrated
under the reduced pressure to give a crude. The crude was purified
by thin layer chromatography on silica gel using
chloroform/methanol for development to give the title compound (22
mg, yield 18%).
[0564] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 11.08 (br, 1H),
10.71 (br, 1H), 8.77 (d, J=6.3 Hz, 1H), 7.88 (d, J=13.6 Hz, 1H),
7.73 (s, 1H), 7.59 (s, 1H), 7.53-7.36 (m, 2H), 7.34-7.25 (m, 5H),
6.87 (d, J=6.3 Hz, 1H), 4.59-4.56 (m, 2H), 4.04 (s, 4H), 3.95-3.92
(m, 2H), 3.74 (s, 2H), 2.08 (s, 9H)
[0565] Mass spectrometric value (m/z): 573 [M+H].sup.+
Example 14
[0566]
N-{3-Fluoro-4-[(7-hydroxy-6-methoxy-4-quinolyl)-oxy]phenyl}-N'-(2-p-
henylacetyl)urea (100 mg), potassium carbonate (145 mg), and
1-bromo-3-chloropropane (53 .mu.l) were dissolved in
dimethylformamide (5 ml) to prepare a solution which was then
stirred at room temperature for 5 hr. The reaction solution was
filtered through Celite, and the filtrate was concentrated under
the reduced pressure to give a crude. The crude was purified by
thin layer chromatography on silica gel using chloroform/methanol
for development to give the title compound (90 mg, yield 78%).
[0567] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 11.21 (br, 1H),
10.34 (br, 1H), 8.43 (d, J=5.4 Hz, 1H), 7.92 (d, J=10.2 Hz, 1H),
7.83 (d, J=12.2 Hz, 1H), 7.50 (s, 1H), 7.39-7.28 (m, 7H), 6.41 (d,
J=5.1 Hz, 1H), 3.94 (s, 3H), 3.63 (s, 2H), 2.67 (m, 3H), 2.43 (s,
1H), 1.93-1.82 (m, 2H)
[0568] Mass spectrometric value (m/z): 538 [M+H].sup.+
Example 15
[0569] Dimethyl methyl malonate [starting compound B] (1.33 ml) was
dissolved in ethanol/water (10/1, 6 ml) to prepare a solution.
Lithium hydroxide monohydrate (0.42 g) was added to the solution,
and the mixture was stirred at room temperature overnight. The
reaction solution was concentrated under the reduced pressure to
give 1.41 g of a crude. This crude (0.71 g),
4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline [starting compound A]
(1.00 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
hydrochloride (0.97 g), and 1-hydroxybenzotriazole monohydrate
(0.78 g) were dissolved in chloroform (30 ml), and the solution was
heated under reflux overnight. An aqueous saturated sodium
hydrogencarbonate solution was added to the reaction solution, and
the mixture was extracted with chloroform. The chloroform layer was
washed with saturated brine. The chloroform layer was dried over
anhydrous sodium sulfate, and the dried chloroform layer was
concentrated under the reduced pressure to give a crude. The crude
was dissolved in ethanol/water (10/1, 50 ml). Lithium hydroxide
monohydrate (0.28 g) was added to the solution, and the mixture was
stirred at room temperature overnight. The reaction solution was
concentrated under the reduced pressure. Water was added to the
concentrate, and the solution was made weakly acidic by the
addition of hydrochloric acid, followed by extraction with
chloroform. The chloroform layer was dried over anhydrous sodium
sulfate, and the dried chloroform layer was concentrated under the
reduced pressure to give 0.68 g of a crude (hereinafter referred to
simply as "carboxylic acid"). This carboxylic acid (96 mg),
2,4-difluoroaniline [starting compound C] (0.037 ml),
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (70
mg), and 1-hydroxybenzotriazole monohydrate (56 mg) were dissolved
in chloroform (4 ml), and the solution was heated under reflux
overnight. The reaction solution was developed on diatomaceous
earth impregnated with an aqueous saturated sodium
hydrogencarbonate solution, followed by extraction with chloroform.
The solvent in the extract was removed by evaporation to give a
crude. The crude was purified by thin layer chromatography on
silica gel using chloroform/methanol for development to give 105 mg
of the title compound.
[0570] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 1.74 (d, J=7.3
Hz, 3H), 3.47 (q, J=7.3 Hz, 1H), 4.05 (s, 3H), 4.06 (s, 3H), 6.47
(d, J=5.4 Hz, 1H), 6.87-6.95 (m, 2H), 7.18 (d, J=9.0 Hz, 2H), 7.48
(s, 1H), 7.55 (s, 1H), 7.68 (d, J=8.8 Hz, 2H), 8.15-8.23 (m, 1H),
8.45-8.50 (m, 2H), 8.63 (br, 1H)
[0571] Mass spectrometric value (m/z): 508 [M+H].sup.+
Example 268
[0572] Phenylacetyl chloride (86 .mu.l) and potassium thiocyanate
(80 mg) were dissolved in acetonitrile (50 ml) to prepare a
solution which was then stirred at 40.degree. C. for 50 min.
Acetonitrile was removed by evaporation under the reduced pressure
to give a crude. An aqueous saturated sodium hydrogencarbonate
solution and ethyl acetate were added to the crude, and the mixture
was stirred at room temperature for 20 min. The mixture was
extracted with ethyl acetate, followed by washing with saturated
brine. The extract was dried over sodium sulfate, and the solvent
was then removed by evaporation under the reduced pressure to give
a crude which was then dissolved in toluene/ethanol (1/1).
3-Fluoro-4-{[7-(3-morpholinopropoxy)-6-methoxy-4-quinolyl]oxy}aniline
(70 mg) was added to the solution, and the mixture was stirred at
room temperature for 3 hr. The reaction solvent was removed by
evaporation under the reduced pressure, and the residue was
purified by thin layer chromatography on silica gel using
chloroform/methanol for development to give the title compound
(43.6 mg, yield 44.0%).
[0573] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.13 (m, 2H),
2.49 (m, 4H), 2.58 (t, J=7.2 Hz, 2H), 3.73 (m, 4H), 3.76 (s, 2H),
4.03 (s, 3H), 4.28 (t, J=6.6 Hz, 2H), 6.44 (d, J=5.1 Hz, 1H),
7.22-7.48 (m, 8H), 7.54 (s, 1H), 7.93 (m, 1H), 8.46 (br, 1H), 8.50
(d, J=5.1 Hz, 1H), 12.47 (br, 1H)
[0574] Mass spectrometric value (m/z): 605 [M+H].sup.+
Example 269
[0575]
3-Fluoro-4-{[7-(3-morpholinopropoxy)-6-methoxy-4-quinolyl]oxy}anili-
ne (60 mg) was dissolved in chloroform (15 ml) to prepare a
solution. 3-(4-Fluoroanilino)-3-oxopropanoic acid (50 mg),
1-hydroxybenzotriazole monohydrate (43 mg), and
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (54 mg)
were added to the solution, and the mixture was heated under reflux
for 3 hr, followed by washing with an aqueous saturated sodium
hydrogencarbonate solution. The solvent was then removed by
evaporation under the reduced pressure to give a crude. The crude
was purified by column chromatography on silica gel using
chloroform/methanol for development to give the title compound (41
mg, yield 48%).
[0576] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.04-2.10 (m,
2H), 2.35-2.46 (m, 4H), 2.51 (t, J=7.1 Hz, 2H), 3.50 (s, 2H),
3.63-3.68 (m, 4H), 3.96 (s, 3H), 4.18 (t, J=6.6 Hz, 2H), 6.32 (d,
J=5.3 Hz, 1H), 6.97-7.02 (m, 2H), 7.13-7.24 (m, 2H), 7.36 (s, 1H),
7.43-7.50 (m, 2H), 7.49 (s, 1H), 7.70-7.74 (m, 1H), 8.40 (d, J=5.3
Hz, 1H), 8.55 (s, 1H), 9.35 (s, 1H)
[0577] Mass spectrometric value (ESI-MS, m/z): 607 [M+H].sup.+
[0578] Compounds of Examples 1 to 15, 268, and 269 had the
following respective structures.
##STR00022## ##STR00023##
[0579] Compounds of Examples 16 to 267 were synthesized as
described in Examples 1 to 15, 268, and 269. For these compounds,
chemical structural formulae, starting compounds, synthesis
methods, and data for identifying the compounds are as follows.
TABLE-US-00001 Ex. No. Compound structure 16 ##STR00024## 17
##STR00025## 18 ##STR00026## 19 ##STR00027## 20 ##STR00028## 21
##STR00029## 22 ##STR00030## 23 ##STR00031## 24 ##STR00032## 25
##STR00033## 26 ##STR00034## 27 ##STR00035## 28 ##STR00036## 29
##STR00037## 30 ##STR00038## 31 ##STR00039## 32 ##STR00040## 33
##STR00041## 34 ##STR00042## 35 ##STR00043## 36 ##STR00044## 37
##STR00045## 38 ##STR00046## 39 ##STR00047## 40 ##STR00048## 41
##STR00049## 42 ##STR00050## 43 ##STR00051## 44 ##STR00052## 45
##STR00053## 46 ##STR00054## 47 ##STR00055## 48 ##STR00056## 49
##STR00057## 50 ##STR00058## 51 ##STR00059## 52 ##STR00060## 53
##STR00061## 54 ##STR00062## 55 ##STR00063## 56 ##STR00064## 57
##STR00065## 58 ##STR00066## 59 ##STR00067## 60 ##STR00068## 61
##STR00069## 62 ##STR00070## 63 ##STR00071## 64 ##STR00072## 65
##STR00073## 66 ##STR00074## 67 ##STR00075## 68 ##STR00076## 69
##STR00077## 70 ##STR00078## 71 ##STR00079## 72 ##STR00080## 73
##STR00081## 74 ##STR00082## 75 ##STR00083## 76 ##STR00084## 77
##STR00085## 78 ##STR00086## 79 ##STR00087## 80 ##STR00088## 81
##STR00089## 82 ##STR00090## 83 ##STR00091## 84 ##STR00092## 85
##STR00093## 86 ##STR00094## 87 ##STR00095## 88 ##STR00096## 89
##STR00097## 90 ##STR00098## 91 ##STR00099## 92 ##STR00100## 93
##STR00101## 94 ##STR00102## 95 ##STR00103## 96 ##STR00104## 97
##STR00105## 98 ##STR00106## 99 ##STR00107## 100 ##STR00108## 101
##STR00109## 102 ##STR00110## 103 ##STR00111## 104 ##STR00112## 105
##STR00113## 106 ##STR00114## Ex. Starting Starting No. compound A
compoud B 16 ##STR00115## ##STR00116## 17 ##STR00117## ##STR00118##
18 ##STR00119## ##STR00120## 19 ##STR00121## ##STR00122## 20
##STR00123## ##STR00124## 21 ##STR00125## ##STR00126## 22
##STR00127## ##STR00128## 23 ##STR00129## ##STR00130## 24
##STR00131## ##STR00132## 25 ##STR00133## ##STR00134## 26
##STR00135## ##STR00136## 27 ##STR00137## ##STR00138## 28
##STR00139## ##STR00140## 29 ##STR00141## ##STR00142## 30
##STR00143## ##STR00144## 31 ##STR00145## ##STR00146## 32
##STR00147## ##STR00148## 33 ##STR00149## ##STR00150## 34
##STR00151## ##STR00152## 35 ##STR00153## ##STR00154## 36
##STR00155## ##STR00156## 37 ##STR00157## ##STR00158## 38
##STR00159## ##STR00160## 39 ##STR00161## ##STR00162## 40
##STR00163## ##STR00164## 41 ##STR00165## ##STR00166## 42
##STR00167## ##STR00168## 43 ##STR00169## ##STR00170## 44
##STR00171## ##STR00172## 45 ##STR00173## ##STR00174## 46
##STR00175## ##STR00176##
47 ##STR00177## ##STR00178## 48 ##STR00179## ##STR00180## 49
##STR00181## ##STR00182## 50 ##STR00183## ##STR00184## 51
##STR00185## ##STR00186## 52 ##STR00187## ##STR00188## 53
##STR00189## ##STR00190## 54 ##STR00191## ##STR00192## 55
##STR00193## ##STR00194## 56 ##STR00195## ##STR00196## 57
##STR00197## ##STR00198## 58 ##STR00199## ##STR00200## 59
##STR00201## ##STR00202## 60 ##STR00203## ##STR00204## 61
##STR00205## ##STR00206## 62 ##STR00207## ##STR00208## 63
##STR00209## ##STR00210## 64 ##STR00211## ##STR00212## 65
##STR00213## ##STR00214## 66 ##STR00215## ##STR00216## 67
##STR00217## ##STR00218## 68 ##STR00219## ##STR00220## 69
##STR00221## ##STR00222## 70 ##STR00223## ##STR00224## 71
##STR00225## ##STR00226## 72 ##STR00227## ##STR00228## 73
##STR00229## ##STR00230## 74 ##STR00231## ##STR00232## 75
##STR00233## ##STR00234## 76 ##STR00235## ##STR00236## 77
##STR00237## ##STR00238## 78 ##STR00239## ##STR00240## 79
##STR00241## ##STR00242## 80 ##STR00243## ##STR00244## 81
##STR00245## ##STR00246## 82 ##STR00247## ##STR00248## 83
##STR00249## ##STR00250## 84 ##STR00251## ##STR00252## 85
##STR00253## ##STR00254## 86 ##STR00255## ##STR00256## 87
##STR00257## ##STR00258## 88 ##STR00259## ##STR00260## 89
##STR00261## ##STR00262## 90 ##STR00263## ##STR00264## 91
##STR00265## ##STR00266## 92 ##STR00267## ##STR00268## 93
##STR00269## ##STR00270## 94 ##STR00271## ##STR00272## 95
##STR00273## ##STR00274## 96 ##STR00275## ##STR00276## 97
##STR00277## ##STR00278## 98 ##STR00279## ##STR00280## 99
##STR00281## ##STR00282## 100 ##STR00283## ##STR00284## 101
##STR00285## ##STR00286## 102 ##STR00287## ##STR00288## 103
##STR00289## ##STR00290## 104 ##STR00291## ##STR00292## 105
##STR00293## ##STR00294## 106 ##STR00295## Mass spectro- Ex.
Starting metric value Synthesis No. compound C (m/z) H.sup.1-NMR
method.sup.a 16 476[M + H]+ (CDCl3, 400 MHz): .delta. 3.75(s, 2 H),
4.01 Ex. 4 (s, 3 H), 4.02(s, 3 H), 6.49(d, J = 5.3 Hz, 1 H),
6.95-7.00(m, 2 H), 7.28-7.48 (m, 5 H), 7.41(s, 1 H), 7.50(s, 1 H),
8.01(s, 1 H), 8.18(t, J = 9.1 Hz, 1 H), 8.49(d, J = 5.3 Hz, 1 H),
10.74(s, 1 H) 17 476[M + H]+ (CDCl3, 400 MHz): .delta. 3.75(s, 2
H), 4.03 Ex. 4 (s, 3 H), 4.04(s, 3 H), 6.38(d, J = 5.3 Hz, 1 H),
6.97-7.42(m, 7 H), 7.40(s, 1 H), 7.55(s, 1 H), 7.65-7.68(m, 1 H),
8.09(s, 1 H), 8.46(d, J = 5.3 Hz, 1 H), 10.60(s, 1 H) 18 492[M +
H]+ (CDCl3, 400 NHz): .delta. 375(s, 2 H), 4.03 Ex. 4 (s, 3 H),
4.04(s, 3 H), 6.29(d, J = 5.3 Hz, 1 H), 7.17-7.43(m, 7 H), 7.41(s,
1 H), 7.56(s, 1 H), 7.82(d, J = 2.5 Hz, 1 H), 8.07(br, 1 H),
8.45(d, J = 5.3 Hz, 1 H), 10.62(s, 1 H) 19 482[M + H]+ (DMSO-d6,
400 MHz): .delta. 11.23(br, 1 H), Ex. 3 10.75(br, 1 H), 8.49(d, J =
5.1 Hz, 1 H), 8.22(m, 1 H), 7.52-7.37(m, 3 H), 7.23(m, 1 H),
7.10-7.02(m, 2 H), 6.87- 6.85(m, 1 H), 6.56(d, J = 5.4 Hz, 1 H),
3.94(s, 6 H), 3.77(s, 2 H) 20 482[M + H]+ (DMSO-d6, 400 MHz):
.delta. 11.00(br, 1 H), Ex. 3 10.63(br, 1 H), 8.48(d, J = 5.1 Hz, 1
H), 7.82(d, J = 14.15 Hz, 1 H), 7.52- 7.38(m, 5 H), 7.23(m, 1 H),
7.02(d, J = 6.1 Hz, 1 H), 6.45(d, J = 5.4 Hz, 1 H), 3.95(s, 6 H),
3.77(s, 2 H) 21 498[M + H]+ (DMSO-d6, 400 MHz): .delta. 10.63(br, 1
H), Ex. 3 8.47(d, J = 5.1 Hz, 1 H), 8.01(s, 1 H), 7.59-7.38(m, 5
H), 7.23(s, 1 H), 7.09 (d, J = 4.8 Hz, 1 H), 7.02(d, J = 4.8 Hz, 1
H), 6.35(d, J = 5.4 Hz, 1 H), 3.94 (s, 6 H), 3.77(s, 2 H) 22 476[M
+ H]+ (DMSO-d6, 400 MHz): .delta. 10.96(br, 1 H), Ex. 3 10.50(br, 1
H), 8.31(d, J = 5.4 Hz, 1 H), 7.65(d, J = 9.0 Hz, 2 H), 7.38-
7.08(m, 8 H), 6.45(d, J = 5.1 Hz, 1 H), 3.94(s, 3 H), 3.93(s, 3 H),
3.74(s, 2 H) 23 494[M + H]+ (DMSO-d6, 400 MHz): .delta. 11.03(br, 1
H), Ex. 3 10.61(br, 1 H), 8.47(d, J = 5.4 Hz, 1 H), 7.81(d, J =
14.1 Hz, 1 H), 7.52 (s, 1 H), 7.42-7.08(m, 6 H), 6.85(br, 1 H),
6.44(d, J = 4.9 Hz, 1 H), 3.94(s, 6 H), 3.75(s, 2 H) 24 510[M + H]+
(DMSO-d6, 400 MHz): .delta. 11.08(br, 1 H), Ex. 3 10.62(br, 1 H),
8.46(d, J = 5.1 Hz, 1 H), 7.85(d, J = 2.7 Hz, 1 H), 7.59- 7.57(m, 1
H), 7.52(br, 1 H), 7.42-7.09 (m, 5 H), 6.87(br, 1 H), 6.34(d, J =
5.1 Hz, 1 H), 3.93(s, 6 H), 3.75(s, 2 H) 25 498[M + Na]+ (CDCl3,
400 MHz): .delta. 3.79(s, 2 H), 4.05 Ex. 3 (s, 3 H), 4.06(s, 3 H),
6.47(d, J = 5.1 Hz, 1 H), 7.13-7.42(m, 6 H), 7.46(s, 1 H), 7.55(s,
1 H), 7.60(d, J = 9.0 Hz, 2 H), 7.73(s, 1 H), 8.48(d, J = 5.4 Hz, 1
H), 10.47(s, 1 H) 26 516[M + Na]+ (CDCl3, 400 MHz): .delta. 3.80(s,
2 H), 4.04 Ex. 3 (s, 3 H), 4.06(s, 3 H), 6.52(d, J = 5.4 Hz, 1 H),
6.96-7.02(m, 2 H), 7.13-7.42 (m, 4 H), 7.46(s, 1 H), 7.49(s, 1 H),
7.76(s, 1 H), 8.20-8.26(m, 1 H), 8.51 (d, J = 5.4 Hz, 1 H),
10.68(s, 1 H) 27 494[M + H]+ (DMSO-d6, 400 MHz): .delta. 10.62(br,
1 H), Ex. 3 8.48(d, J = 5.1 Hz, 1 H), 7.82(d, J = 13.9 Hz, 1 H),
7.52-7.11(m, 8 H), 6.93 (br, 1 H), 6.45(d, J = 5.1 Hz, 1 H),
3.85(s, 2 H), 3.44(s, 6 H) 28 532[M + Na]+ (CDCl3, 400 MHz):
.delta. 3.79(s, 2 H), 4.06 Ex. 3 (s, 3 H), 4.07(s, 3 H), 6.34(d, J
= 5.4 Hz, 1 H), 7.14-7.54(m, 7 H), 7.59(s, 1 H), 7.70(s, 1 H),
7.84(d, J = 2.7 Hz, 1 H), 8.48(d, J = 5.4 Hz, 1 H), 10.55 (s, 1 H)
29 464[M + H]+ (DMSO-d6, 400 MHz): .delta. 10.97(br, 1 H), Ex. 3
10.47(br, 1 H), 8.47(d, J = 5.4 Hz, 1 H), 7.67-7.65(m, 2 H),
7.50(s, 1 H), 7.44(d, J = 6.6 Hz, 1 H), 7.39(s, 1 H),
&.25-7.23(m, 2 H), 7.01-6.99(m, 2 H), 6.46(d, J = 5.4 Hz, 1 H),
4.00(s, 2 H), 3.98(s, 6 H) 30 482[M + H]+ (DMSO-d6, 400 MHz):
.delta. 11.17(br, 1 H), Ex. 3 10.69(br, 1 H), 8.47(d, J = 5.1 Hz, 1
H), 8.23-8.19(m, 1 H), 7.47-7.33(m, 3 H), 7.14(d, J = 8.8 Hz, 1 H),
7.02- 6.89(m, 3 H), 6.55(d, J = 5.1 Hz, 1 H), 3.98(s, 2 H), 3.92(s,
6 H) 31 482[M + H]+ (DMSO-d6, 400 MHz): .delta. 8.48(d, J = 5.1 Ex.
3 Hz, 1 H), 7.82(d, J = 13.4 Hz, 1 H), 7.53-7.33(m, 4 H),
7.01-6.89(m, 5 H), 6.45(d, J = 5.1 Hz, 1 H), 3.97(s, 2 H), 3.95(s,
6 H) 32 498[M + H]+ (DMSO-d6, 400 MHz): .delta. 11.04(br, 1 H), Ex.
3 10.54(br, 1 H), 8.47(d, J = 5.1 Hz, 1 H), 8.00(s, 1 H),
7.61-7.59(m, 1 H), 7.53(s, 1 H), 7.45-7.33(m, 3 H), 7.01- 6.89(m, 2
H), 6.35(d, J = 5.1 Hz, 1 H), 3.99(s, 2 H), 3.94(s, 6 H) 33 512[M +
H]+ (CDCl3, 400 MHz): .delta. 3.74(s, 2 H), 4.01 Ex. 3 (s, 3 H),
4.03(s, 3 H), 6.49(d, J = 5.3 Hz, 1 H), 6.86-6.99(m, 4 H),
7.21-7.32 (m, 1 H), 7.41(s, 1 H), 7.47(s, 1 H), 8.15(br, 1 H),
8.20(t, J = 9.5 Hz, 1 H), 8.49(d, J = 5.3 Hz, 1 H), 10.63 (s, 1 )
34 512[M + H]+ (CDCl3, 400 MHz): .delta. 3.74(s, 2 H), 4.02 Ex. 3
(s, 3 H), 4.04(s, 3 H), 6.39(d, J = 5.3 Hz, 1 H), 6.88-7.69(m, 6
H), 7.24(s, 1 H), 7.55(s, 1 H), 8.29(br, 1 H), 8.48 (d, J = 5.3 Hz,
1 H), 10.56(s, 1 H) 35 512[M + H]+ (CDCl3, 400 MHz): .delta.
3.73(s, 2 H), 4.06 Ex. 3 (s, 6 H), 6.42(d, J = 5.1 Hz, 1 H),
7.03-7.08(m, 1 H), 7.14-7.26(m, 4 H), 7.49(br, 1 H), 7.58(s, 1 H),
7.67-7.72 (m, 1 H), 8.13(br, 1 H), 8.51(d, J = 5.1 Hz, 1 H),
10.56(s, 1 H) 36 494[M + H]+ (CDCl3, 400 MHz): .delta. 3.74(s, 2
H), 4.01 Ex. 3 (s, 3 H), 4.03(s, 3 H), 6.50(d, J = 5.3 Hz, 1 H),
6.51-7.10(m, 5 H), 7.31-7.35 (m, 1 H), 7.42(s, 1 H), 7.47(s, 1 H),
8.18(t, J = 9.5Hz, 1 H), 8.50(d, J = 5.3 Hz, 1 H), 8.89(s, 1 H),
10.74(s, 1 H) 37 494[M + H]+ (CDCl3, 400 MHz): .delta. 3.74(s, 2
H), 4.03 Ex. 3
(s, 3 H), 4.04(s, 3 H), 6.39(d, J = 5.3 Hz, 1 H), 7.02-7.68(m, 7
H), 7.41(s, 1 H), 7.55(s, 1 H), 8.26(s, 1 H), 8.47 (d, J = 5.3 Hz,
1 H), 10.60(s, 1 H) 38 506[M + H]+ (DMSO-d6, 400 MHz): .delta.
10.98(br, 1 H), Ex. 3 10.84(br, 1 H), 8.47(d, J = 5.4 Hz, 1 H),
8.25(d, J = 8.8 Hz, 1 H), 7.51(s, 1 H), 7.38-7.04(m, 6 H),
6.84-6.82(m, 1 H), 6.49(d, J = 5.1 Hz, 1 H), 3.95(s, 3 H), 3.93(s,
3 H), 3.84(s, 3 H), 3.72 (s, 2 H) 39 516[M + Na]+ (CDCl3, 400 MHz):
.delta. 3.72(s, 2 H), 4.04 Ex. 3 (s, 3 H), 4.05(s, 3 H), 6.47(d, J
= 5.4 Hz, 1 H), 7.03-7.09(m, 1 H), 7.15-7.23 (m, 4 H), 7.44(s, 1
H), 7.43(s, 1 H), 7.60(d, J = 9.0 Hz, 2 H), 8.49(d, J = 5.4 Hz, 1
H), 8.67(s, 1 H), 10.51(s, 1 H) 40 570[M + H]+ (DMSO-d6, 400 MHz):
.delta. 11.16(br, 1 H), Ex. 3.sup.b 10.75(br, 1 H), 8.49(d, J = 4.9
Hz, 1 H), 8.24-8.19(m, 1 H), 7.53-7.35(m, 10 H), 7.19-7.11(m, 3 H),
6.56(d, J = 5.4 Hz, 1 H), 5.31(s, 2 H), 3.94(s, 3 H), 3.75(s, 2 H)
41 ##STR00296## 621[M + H]+ (DMSO-d6, 400 MHz): .delta. 11.03(br, 1
H),10.60(br, 1 H), 8.46(d, J = 5.1 Hz,1 H), 7.80(d, J = 13.6 Hz, 1
H), 7.51-7.07(m, 5 H), 6.85(br, 3 H), 6.43(d, J =5.1 Hz, 1 H),
4.18-4.16(m, 2 H), 3.95(s, 3 H), 3.58-3.56(m, 3 H), 2.89(s,2 H),
2.73(s, 2 H), 2.36(s, 5 H), 1.84(m, 2 H), 1.63(m, 2 H) Ex. 12 42
##STR00297## 619[M + H]+ (DMSO-d6, 400 MHz): .delta. 11.04(br, 1
H),10.62(br, 1 H), 8.46(d, J = 5.4 Hz,1 H), 7.81(d, J = 13.4 Hz, 1
H), 7.53(s, 1 H), 7.41-7.33(m, 5 H), 7.19-7.14(m, 2 H), 6.44(d, J =
5.1 Hz, 1 H), 4.19(m, 2 H), 3.95(s, 2 H), 3.75(s, 2 H),3.29-3.27(m,
3 H), 2.50-2.49(m, 2 H),1.90-1.85(m, 3 H), 1.69(m, 9 H) Ex. 12 43
##STR00298## 634[M + H]+ (DMSO-d6, 400 MHz): .delta. 11.03(br, 1
H),10.61(br, 1 H), 8.45(d, J = 3.9 Hz,1 H), 7.81(d, J = 13.4 Hz, 1
H), 7.50(s, 1 H), 7.41-7.34(m, 5 H), 7.18-7.14(m, 2 H), 6.42(d, J =
8.1 Hz, 1 H),4.18-4.15(m, 2 H), 3.94(s, 3 H), 3.74(s, 2 H),
3.29-3.28(m, 4 H), 2.50-2.49(m, 4 H), 2.36(br, 2 H), 2.18-2.17(m,3
H), 1.83(m, 2 H), 1.61(m, 2 H) Ex. 12 44 ##STR00299## 621[M + H]+
(DMSO-d6, 400 MHz): .delta. 11.16(br, 1 H),10.75(br, 1 H), 8.47(d,
J = 5.1 Hz,1 H), 8.22(m, 1 H), 7.95(m, 1 H), 7.46-7.08(m, 3 H),
6.86(br, 4 H), 6.55(d, J =5.4 Hz, 1 H), 4.19-4.17(m, 2 H), 3.92(s,
4 H), 3.75(s, 2 H), 3.57(br, 4 H),2.49(br, 5 H), 1.84(m, 2 H),
1.62(m,2 H) Ex. 12 45 ##STR00300## 619[M + H]+ (DMSO-d6, 400 MHz):
.delta. 11.16(br, 1 H),10.76(br, 1 H), 8.49(d, J = 5.1 Hz,1 H),
8.25-8.20(m, 1 H), 7.48(s, 1 H),7.42-7.34(m, 4 H), 7.19-7.10(m, 3
H),6.56(d, J = 5.4 Hz, 1 H), 4.19(br,2 H), 3.93(s, 3 H), 3.75(s, 2
H), 3.34-3.28(m, 6 H), 2.50-2.49(m, 5 H), 1.91-1.85(m, 5 H) Ex. 12
46 ##STR00301## 607[M + H]+ (DMSO-d6, 400 MHz): .delta. 11.21(br, 1
H),10.54(br, 1 H), 8.31(d, J = 5.2 Hz,1 H), 7.81(d, J = 13.5 Hz, 1
H), 7.48-7.06(m, 5 H), 6.51(br, 3 H), 6.31(d, J =5.1 Hz, 1 H),
4.18-4.13(m, 2 H), 3.94(s, 3 H), 3.57-3.50(m, 3 H), 2.89(s,2 H),
2.73(s, 2 H), 2.36(br, 3 H), 1.81(m, 2 H), 1.61(m, 2 H) Ex. 11 47
##STR00302## 605[M + H]+ (DMSO-d6, 400 MHz): .delta. 11.04(br, 1
H),10.62(br, 1 H), 8.48(d, J = 5.4 Hz,1 H), 7.81(d, J = 13.2 Hz, 1
H), 7.55(s, 1 H), 7.45-7.35(m, 5 H), 7.19-7.15(m, 2 H), 6.46(d, J =
5.4 Hz, 1 H), 4.18(br, 2 H), 3.96(s, 3 H), 3.75(s, 2 H),3.51(br, 1
H), 3.29(m, 5 H), 2.50-2.49(m, 4 H), 2.26(m, 2 H), 1.83(m, 1
H),1.70(m, 1 H) Ex. 11 48 ##STR00303## 591[M + H]+ (DMSO-d6, 400
MHz): .delta. 11.04(br, 1 H),01.62(br, 1 H), 8.48(d, J = 5.1 Hz,1
H), 7.81(d, J = 14.2 Hz, 1 H), 7.55(s, 1 H), 7.48-7.34(m, 5 H),
7.18-7.14(m, 2 H), 6.45(d, J = 4.9 Hz, 1 H), 3.96(s, 3 H), 3.75(s,
2 H), 2.50-2.49(m,7 H), 1.91-1.23(m, 7 H) Ex. 13 49 ##STR00304##
606[M + H]+ (DMSO-d6, 400 MHz): .delta. 11.04(br, 1 H),10.61(br, 1
H), 8.46(d, J = 5.4 Hz,1 H), 7.80(d, J = 13.6 Hz, 1 H), 7.52(s, 1
H), 7.43-7.35(m, 5 H), 7.18-7.14(m, 2 H), 6.43(d, J = 5.1 Hz, 1 H),
4.27(br, 2 H), 3.94(s, 3 H), 3.74(s, 2 H),2.89-2.38(m, 8 H),
1.27-1.39(m, 5 H) Ex. 13 50 ##STR00305## 605[M + H]+ (DMSO-d6, 400
MHz): .delta. 11.16(br, 1 H),10.77(br, 1 H), 8.51(d, J = 5.3 Hz,1
H), 8.23(m, 1 H), 7.50-7.17(m, 8 H),6.95(d, J = 5.3 Hz, 1 H),
4.26(br,2 H), 3.93(s, 4 H), 3.75(br, 2 H), 3.50(m, 1 H), 3.29(m 3
H), 2.94(m, 1 H),2.67(s, 1 H), 2.49(m, 3 H), 2.32-2.25(m, 2 H),
1.83(m, 1 H), 1.69(m, 1 H) Ex. 11 51 ##STR00306## 620[M + H]+
(DMSO-d6, 400 MHz): .delta. 11.10(br, 1 H),10.76(br, 1 H), 8.50(d,
J = 5.1 Hz,1 H), 8.23(m, 1 H), 7.50-7.14(m, 8 H),6.93(d, J = 5.1
Hz, 1 H), 4.22(br,2 H), 3.94(s, 3 H), 3.75(s, 2 H), 3.29(m, 6 H),
2.67(s, 1 H), 2.52-2.49(m,7 H), 2.32(s, 1 H) Ex. 11 52 ##STR00307##
587[M + H]+ (DMSO-d6, 400 MHz): .delta. 11.05(br, 1 H),10.63(br, 1
H), 8.46(d, J = 5.1 Hz,1 H), 7.81(d, J = 13.9 Hz, 1 H), 7.53(s, 3
H), 7.43-7.27(m, 8 H), 6.44(d, J =5.1 Hz, 1 H), 4.23(m, 1 H),
3.95(s,1 H), 3.74(s, 2 H), 3.28-3.26(m, 4 H),2.89(s, 1 H), 2.73(s,
1 H), 2.50-2.48(m, 5 H), 1.67-1.23(m, 4 H) Ex. 11 53 ##STR00308##
602[M + H]+ (DMSO-d6, 400 MHz): .delta. 11.04(br, 1 H),10.63(br, 1
H), 8.45(d, J = 5.4 Hz,1 H), 7.95(d, J = 11.2 Hz, 1 H), 7.80(d, J =
13.9 Hz, 1 H), 7.50(s, 1 H),7.39-7.28(m, 5 H), 6.41(d, J = 5.1 Hz,1
H), 4.19-4.16(m, 2 H), 3.94(s, 3 H),3.74(s, 2 H), 3.36-3.27(m, 7
H), 2.89(s, 1 H), 2.73(s, 1 H), 2.32-2.19(m,6 H), 1.98-1.95(m, 2 H)
Ex. 11 54 ##STR00309## 575[M + H]+ (DMSO-d6, 400 MHz): .delta.
11.12(br, 1 H),10.51(br, 1 H), 8.45(d, J = 5.3 Hz,1 H), 7.80(d, J =
13.9 Hz, 1 H), 7.52(s, 1 H), 7.43-7.28(m, 8 H), 6.41(d, J =5.3 Hz,
1 H), 4.29(br, 2 H), 3.94(s,3 H), 3.89(s, 2 H), 3.61-3.56(m, 4
H),2.52-2.49(m, 6 H) Ex. 13 55 ##STR00310## 593[M + H]+ (DMSO-d6,
400 MHz): .delta. 11.10(br, 1 H),10.75(br, 1 H), 8.49(d, J = 5.3
Hz,1 H), 8.21(m, 1 H), 7.53-7.09(m, 8 H),6.44(d, J = 5.3 Hz, 1 H),
4.28(br,2 H), 3.94(s, 3 H), 3.88(s, 2 H), 3.60-3.51(m, 4 H),
3.25-3.24(m, 2 H), 2.51-2.48(m, 4 H) Ex. 13 56 510[M + H]+
(DMSO-d6, 400 MHz): .delta. 12.69(br, 1 H), Ex. 2 12.04(br, 1 H),
8.72(d, J = 5.9 Hz, 1 H), 8.25(d, J = 8.5 Hz, 1 H), 8.17(d, J = 8.3
Hz, 1 H), 8.05(d, J = 8.8 Hz, 1 H), 7.97(d,J = 8.8 Hz, 1 H),
7.84(d, J = 7.1 Hz, 1 H), 7.68-7.61(m, 4 H), 7.48-7.43(m, 4 H),
6.79(d, J = 5.9 Hz, 1 H), 4.00(s, 6 H) 57 528[M + H]+ (DMSO-d6, 400
MHz): .delta. 12.54(br, 1 H), Ex. 2 12.21(br, 1 H), 8.57(d, J = 5.4
Hz, 1 H), 8.23-8.14(m, 3 H), 8.05(d, J = 7.6 Hz, 1 H), 7.86(d, J =
6.1 Hz, 1 H), 7.69-7.52(m, 3 H), 7.48-7.41(m, 3 H), 7.19(m, 1 H),
6.69(d, J = 5.1 Hz, 1 H), 3.98(s, 3 H), 3.93(s, 3 H) 58 492[M + H]+
(DMSO-d6, 400 MHz): .delta. 12.26(br, 1 H), Ex. 1 11.89(br, 1 H),
8.55(d, J = 5.1 Hz, 1 H), 8.05(t, J = 8.7 Hz, 1 H), 7.46(s, 1 H),
7.41(s, 1 H), 7.29-7.35(m, 6 H), 7.13(d, J = 9.5 Hz, 1 H), 6.64(d,
J = 5.1 Hz, 1 H), 3.95(s, 3 H), 3.92(s, 3 H), 3.83(s, 2 H) 59 508[M
+ H]+ (DMSO-d6, 400 MHz): .delta. 3.92(s, 3 H), Ex. 2 3.95(s, 3 H),
4.04(s, 2 H), 6.54(d, J = 5.1 Hz, 1 H), 7.27-7.50(m, 7 H), 7.74-
7.79(m, 2 H), 8.31(s, 1 H), 8.51(d, J = 5.1 Hz, 1 H),
11.80-11.83(br, 1 H) 60 474[M + H]+ (DMSO-d6, 400 MHz): .delta.
12.47(br, 1 H), Ex. 1 11.81(br, 1 H), 8.14-8.16(m, 1 H), 7.69 (m, 1
H), 7.51(s, 1 H), 7.48(d, J = 8.8 Hz, 1 H), 7.44(s, 1 H),
7.25-7.35(m, 7 H), 6.51(d, J = 6.1 Hz, 1 H), 3.98(s, 3 H), 3.96(s,
3 H), 3.82(s, 2 H) 61 480[M + H]+ (DMSO-d6, 400 MHz): .delta.
12.41(br, 1 H), Ex. 2 11.48(br, 1 H), 8.63(m, 1 H), 7.81-7.84 (m, 2
H), 7.59(s, 1 H), 7.44(s, 1 H) 7.34-7.36(m, 2 H), 6.67(m, 1 H),
3.95 (s, 6 H), 2.37(d, J = 6.8 Hz, 2 H), 1.69 (m, 3 H),
1.19-1.25(m, 6 H), 0.86-1.00 (m, 2 H) 62 456[M + H]+ (DMSO-d6, 400
MHz): .delta. 12.48(br, 1 H), Ex. 2 10.09(br, 1 H), 8.54(d, J = 6.3
Hz, 1 H), 8.09(s, 1 H), 7.90(d, J = 8.8 Hz, 1 H), 7.62(s, 1 H),
7.26-7.25(m, 3 H), 6.74(d, J = 6.1 Hz, 1 H), 4.22(s, 3 H), 4.16(s,
3 H), 3.79-3.77(m, 2 H), 3.66- 3.62(m, 2 H), 2.65-2.64(m, 2 H),
1.23- 1.18(m, 3 H) 63 508[M + H]+ (CDCl3, 400 MHz): .delta. 3.76(s,
2 H), 4.05 Ex. 1 (s, 3 H), 4.06(s, 3 H), 6.39(d, J = 5.1 Hz, 1 H),
7.23-7.47(m, 6 H), 7.51(s, 1 H), 7.57(s, 1 H), 7.61-7.64(m, 1 H),
8.00(d, J = 2.4 Hz, 1 H), 8.53(d, J = 5.4 Hz, 1 H) 64 520[M + H]+
(DMSO-d6, 400 MHz): .delta. 12.62(br, 1 H), Ex. 2 11.64(br, 1 H),
8.51(d, J = 5.4 Hz, 1 H), 8.64(d, J = 11.5 Hz, 1 H), 7.57- 7.42(m,
4 H), 7.16-7.13(m, 4 H), 6.51 (d,J = 5.4 Hz, 1 H), 3.96(s, 8 H),
2.91-2.88(m, 1 H), 2.79-7.75(m, 1 H), 2.31(s, 3 H) 65 508[M + H]+
(DMSO-d6, 400 MHz): .delta. 12.37(br, 1 H), Ex. 1 11.89(br, 1 H),
8.54(d, J = 5.1 Hz, 1 H), 8.07(d, J = 8.9 Hz, 1 H), 7.56(d, J = 2.7
Hz, 1 H), 7.46(s, 1 H), 7.41(s, 1 H), 7.37-7.23(m, 6 H), 6.63(d, J
= 5.1 Hz, 1 H), 3.94(s, 3 H), 3.91(s, 3 H), 3.84(s, 2 H) 66 480[M +
H]+ (DMSO-d6, 400 MHz): .delta. 12.4 (br, 1 H), Ex. 2 11.69(br, 1
H), 8.53(d, J = 5.1 Hz, 1 H), 8.49-7.00(m, 9 H), 6.56(d, J = 5.1
Hz, 1 H), 3.95(s, 3 H), 3.94(s, 3 H), 3.84(s, 2 H) 67 488[M + H]+
(DMSO-d6, 400 MHz): .delta. 12.42(br, 1 H), Ex. 1 11.73(br, 1 H),
8.47(d, J = 5.4 Hz, 1 H), 8.30(s, 1 H), 7.66-7.63(m, 2 H), 7.55(s,
1 H), 7.39(s, 1 H), 7.35-7.19 (m, 8 H), 6.34(d, J = 5.4 Hz, 1 H),
3.94 (s, 6 H), 3.82(s, 2 H) 68 504[M + H]+ (DMSO-d6, 400 MHz):
.delta. 11.76(br, 1 H), Ex. 1 10.95(br, 1 H), 8.44(d, J = 5.4 Hz, 1
H), 8.30(s, 1 H), 7.63(s, 2 H), 7.51 (s, 1 H), 7.38-7.22(m, 6 H),
6.31(d, J = 5.4 Hz, 1 H), 3.94(s, 3 H), 3.82(s, 6 H), 3.69(s, 2 H)
69 504[M + H]+ (DMSO-d6, 400 MHz): .delta. 12.71(br, 1 H), Ex. 1
11.71(br, 1 H), 8.63(d, J = 8.8 Hz, 1 H), 8.49(d, J = 5.1 Hz, 1 H),
7.50(s, 1 H), 7.40(s, 1 H), 7.38-7.11(m, 5 H), 7.03(s, 1 H),
6.87(d, J = 11.5 Hz, 1 H), 6.57(d, J = 5.1 Hz, 1 H), 3.95(s, 9 H),
3.83(s, 2 H) 70 543[M + H]+ (DMSO-d6, 400 MHz): .delta. 12.43(br, 1
H), Ex. 1 11.89(br, 1 H), 8.48(d, J = 5.1 Hz, 1 H), 8.07(s, 2 H),
7.55(s, 1 H), 7.42 (s, 1 H), 7.35-7.28(m, 5 H), 6.33(d, J = 5.3 Hz,
1 H), 3.95(s, 6 H), 3.83(s, 2 H) 71 492[M + H]+ (DMSO-d6, 400 MHz):
.delta. 12.39(br, 1 H), Ex. 2 11.73(br, 1 H), 8.53(d, J = 5.4 Hz, 1
H), 7.75(d, J = 9.0 Hz, 2 H), 7.51(s, 1 H), 7.41-7.16(m, 7 H),
6.56(d, J = 5.4 Hz, 1 H), 3.95(s, 3 H), 3.93(s, 3 H), 3.83(s, 2 H)
72 510[M + H]+ (DMSO-d6, 400 MHz): .delta. 12.22(br, 1 H), Ex. 2
11.89(br, 1 H), 8.58(d, J = 5.4 Hz, 1 H), 8.04(t, J = 8.8 Hz, 1 H),
7.85(s, 1 H), 7.43-7.11(m, 7 H), 6.68(d, J = 5.4 Hz, 1 H), 3.96(s,
3 H), 3.93(s, 3 H), 3.57(s, 2 H) 73 527[M + H]+ (DMSO-d6, 400 MHz):
.delta. 12.43(br, 1 H), Ex. 2 11.83(br, 1 H), 8.61(d, J = 5.6 Hz, 1
H), 8.15(s, 1 H), 7.73-7.70(m, 1 H), 7.60(s, 1 H), 7.53-7.10(m, 6
H), 6.55 (d, J = 5.1 Hz, 1 H), 3.97(s, 6 H), 3.84 (s, 2 H) 74 510[M
+ H]+ (DMSO-d6, 400 MHz): .delta. 3.88(s, 2 H), 3.91 Ex. 2 (s, 3
H), 3.95(s, 3 H), 6.64(d, J = 5.1 Hz, 1 H), 7.12-7.22(m, 4 H),
7.35-7.47 (m, 4 H), 7.99-8.04(m, 1 H), 8.55(d, J = 5.3 Hz, 1 H),
11.90(s, 1 H), 12.18(s, 1 H) 75 510[M + H]+ (DMSO-d6, 400 MHz):
.delta. 3.87(s, 2 H), Ex. 2 3.94(s, 3 H), 3.95(s, 3 H), 6.49(d, J =
4.9 Hz, 1 H), 7.08-7.23(m, 3 H), 7.34- 7.56(m, 5 H), 8.00-8.05(m, 1
H), 8.50 (d, J = 5.1 Hz, 1 H), 11.82(s, 1 H), 12.44(s, 1 H) 76
526[M + H]+ (DMSO-d6, 400 MHz): .delta. 3.87(s, 2 H), Ex. 2 3.93(s,
3 H), 3.95(s, 3 H), 6.40(d, J = 5.4 Hz, 1 H), 7.09-7.24(m, 3 H),
7.35- 7.54(m, 4 H), 7.65-7.71(m, 1 H), 8.09- 8.13(m, 1 Hz, 1 H),
8.50(d, J = 5.4 Hz, 1 H), 11.82(s, 1 H), 12.38(s, 1 H) 77 488[M +
H]+ (DMSO-d6, 400 MHz): .delta. 2.31(s, 3 H), Ex. 2 3.78(s, 2 H),
3.93(s, 3 H), 3.95(s, 3 H), 6.39(d, J = 5.1 Hz, 1 H), 7.05-
7.27(m, 5 H), 7.41(s, 1 H), 7.45(d, J = 8.8 Hz, 1 H), 7.51(s, 1 H),
7.67(dd, J = 2.4, 8.5 Hz, 1 H), 8.11(d, J = 2.4 Hz, 1 H), 8.49(d, J
= 5.1 Hz, 1 H), 11.79(s, 1 H), 12.44(s, 1 H) 78 522[M + H]+
(DMSO-d6, 400 MHz): .delta. 2.30(s, 3 H), Ex. 2 3.77(s, 2 H),
3.92(s, 3 H), 3.94(s, 3 H), 6.53(d, J = 5.1 Hz, 1 H), 7.08- 7.31(m,
5 H), 7.40(s, 1 H), 7.48(s, 1 H), 7.74(d, J = 8.7 Hz, 2 H), 8.49(d,
J = 5.1 Hz, 1 H), 11.71(s, 1 H), 12.42 (s, 1 H) 79 488[M + H]+
(DMSO-d6, 400 MHz): .delta. 2.29(s, 3 H), Ex. 2 3.89(s, 2 H),
4.02(s, 3 H), 4.04(s, 3 H), 6.87(d, J = 6.6 Hz, 1 H), 7.12- 7.30(m,
4 H), 7.44(d, J = 9.0 Hz, 2 H), 7.51(s, 1 H), 7.74(s, 1 H), 7.88(d,
J = 9.0 Hz, 2 H), 8.12(d, J = 6.4 Hz, 1 H), 11.77(s, 1 H), 12.49(s,
1 H) 80 510[M + H]+ (DMSO-d6, 400 MHz): .delta. 12.45(br, 1 H), Ex.
2 11.87(br, 1 H), 8.56(d, J = 5.6 Hz, 1 H), 8.05-8.02(m, 1 H),
7.56-7.18(m, 8 H), 6.57(d, J = 5.4 Hz, 1 H), 3.96(s, 8 H) 81 510[M
+ H]+ (DMSO-d6, 400 MHz): .delta. 12.19(br, 1 H), Ex. 2 11.95(br, 1
H), 8.62(d, J = 5.6 Hz, 1 H), 8.07-8.05(m, 1 H), 7.51(s, 1 H),
7.43-7.18(m, 7 H), 6.72(d, J = 5.6 Hz, 1 H), 3.97(s, 8 H) 82 522[M
+ H]+ (DMSO-d6, 400 MHz): .delta. 2.29(s, 3 H), Ex. 2 3.77(s, 2 H),
3.93(s, 3 H), 3.95(s, 3 H), 6.39(d, J = 5.1 Hz, 1 H), 7.16(d, J =
8.1 Hz, 2 H), 7.23(d, J = 8.1 Hz, 2 H), 7.41(s, 1 H), 7.46(d, J =
8.8 Hz, 1 H), 7.51(s, 1 H), 7.66(dd, J = 2.7, 9.0 Hz, 1 H), 8.11(d,
J = 2.4 Hz, 1 H), 8.49(d, J = 5.1 Hz, 1 H), 11.78(s, 1 H), 12.44(s,
1 H) 83 522[M + H]+ (DMSO-d6, 400 MHz): .delta. 3.79(s, 3 H), Ex. 2
3.81(s, 2 H), 3.94(s, 3 H), 3.95(s, 3 H), 6.49(d, J = 5.1 Hz, 1 H),
6.88- 7.03(m, 2 H), 7.20-7.32(m, 2 H), 7.41 (s, 1 H), 7.44-7.58(m,
3 H), 8.05(d, J = 12.4 Hz, 1 H), 8.51(d, J = 2.1 Hz, 1 H), 11.71(s,
1 H), 12.55(s, 1 H) 84 506[M + H]+ (CDCl3, 400 MHz): .delta.
2.36(s, 3 H), 3.77 Ex. 2 (s, 2 H), 4.05(s, 6 H), 6.46(d, J = 5.1
Hz, 1 H), 7.22-7.34(m, 5 H), 7.41(d, J = 8.8 Hz, 1 H), 7.46(s, 1
H), 7.55(s, 1 H), 7.95(dd, J = 2.4, 11.7 Hz, 1 H), 8.37(s, 1 H),
8.51(d, J = 5.4 Hz, 1 H), 12.50(s, 1 H) 85 498[M + H]+ (DMSO-d6,
400 MHz): .delta. 12.50(br, 1 H), Ex. 2 11.78(br, 1 H), 8.56(d, J =
5.1 Hz, 1 H), 7.56-7.28(m, 3 H), 7.11-7.00(m, 5 H), 6.57(m, 1 H),
3.95(s, 6 H), 3.84 (s, 2 H) 86 510[M + H]+ (DMSO-d6, 400 MHz):
.delta. 12.71(br, 1 H), Ex. 2 11.67(br, 1 H), 8.64(d, J = 5.1 Hz, 1
H), 8.52-8.48(m, 1 H), 7.52-7.40(m, 4 H), 7.12-7.04(m, 3 H),
6.59(d, J = 5.1 Hz, 1 H), 3.95(s, 6 H), 3.85(s, 5 H) 87 527[M + H]+
(DMSO-d6, 400 mHz): .delta. 12.45(br, 1 H), Ex. 2 11.91(br, 1 H),
8.53(d, J = 5.1 Hz, 1 H), 8.05-8.03(m, 1 H), 7.54-7.33(m, 8 H),
6.56-6.54(m, 1 H), 4.04(s, 2 H), 3.95(s, 6 H) 88 492[M + H]+
(DMSO-d6, 400 MHz): .delta. 12.57(br, 1 H), Ex. 2 11.45(br, 1 H),
8.52(d, J = 5.1 Hz, 1 H), 7.79-7.76(m, 2 H), 7.57(s, 1 H), 7.45(s,
1 H), 7.31-7.28(m, 2 H), 6.54 (d, J = 5.1 Hz, 1 H), 3.97(s, 3 H),
3.95 (s, 3 H), 3.31(s, 2 H), 2.49-2.30(m, 2 H), 1.52-1.08(m, 9 H)
89 510[M + H]+ (DMSO-d6, 400 MHz): .delta. 12.41(br, 1 H), Ex. 2
11.93(br, 1 H), 8.56(d, J = 5.1 Hz, 1 H), 8.15-8.07(m, 1 H),
7.47(s, 1 H), 7.42(s, 1 H), 7.34(d, J = 13.6 Hz, 1 H), 7.15(d, J =
8.8 Hz, 1 H), 6.65(d, J = 5.1 Hz, 1 H), 3.96(s, 3 H), 3.92(s, 3 H),
3.31(s, 2 H), 2.45-2.31(m, 2 H), 1.51-1.07(m, 9 H) 90 510[M + H]+
(DMSO-d6, 400 MHz): .delta. 12.66(br, 1 H), Ex. 2 11.54(br, 1 H),
8.54(d, J = 5.1 Hz, 1 H), 8.08(m, 1 H), 7.55-7.43(m, 4 H), 6.54(d,
J = 5.6 Hz, 1 H), 3.96(s, 6 H), 3.31(s, 2 H), 2.43-2.30(m, 2 H),
1.48- 1.06(m, 9 H) 91 527[M + H]+ (DMSO-d6, 400 MHz): .delta.
12.59(br, 1 H), Ex. 2 11.54(br, 1 H), 8.51(d, J = 5.1 Hz, 1 H),
8.17-8.15(m, 1 H), 7.70-7.68(m, 1 H), 7.53(s, 1 H), 7.47(d, J = 8.8
Hz, 1 H), 7.43(s, 1 H), 6.42(d, J = 5.1 Hz, 1 H), 3.94(s, 6 H),
3.31(s, 2 H), 2.42- 2.31(m, 2 H), 1.47-1.05(m, 9 H) 92 506[M + H]+
(DMSO-d6, 400 MHz): .delta. 12.32(br, 1 H), Ex. 2 11.89(br, 1 H),
8.73(d, J = 5.9 Hz, 1 H), 7.62(s, 1 H), 7.51-7.48(m, 2 H),
7.24-7.12(m, 6 H), 6.84(d, J = 6.1 Hz, 1 H), 4.01(s, 6 H), 3.78(s,
2 H), 2.28 (s, 3 H) 93 ND.sup.c (DMSO-d6, 400 MHz): .delta. 3.92(s,
5 H), Ex. 2 3.95(s, 3 H), 6.65(d, J = 5.4 Hz, 1 H), 7.06-7.50(m, 7
H), 7.99-8.05(m, 1 H), 8.55(d, J = 5.1 Hz, 1 H), 11.94(s, 1 H),
12.12(s, 1 H) 94 528[M + H]+ (DMSO-d6, 400 MHz): .delta. 3.92(s, 2
H), Ex. 2 3.95(s, 3 H), 3.96(s, 3 H), 6.51(d, J = 5.1 Hz, 1 H),
7.04-7.12(m, 2 H), 7.20- 7.29(m, 2 H), 7.41-7.57(m, 3 H), 7.99-
8.05(m, 1 H), 8.52(d, J = 5.1 Hz, 1 H), 11.87(s, 1 H), 12.39(s, 1
H) 95 528[M + H]+ (DMSO-d6, 400 MHz): .delta. 12.32(br, 1 H), Ex. 2
11.94(br, 1 H), 8.51(d, J = 5.1 Hz, 1 H), 8.02-7.99(m, 1 H),
7.54-7.41(m, 4 H), 7.15-7.11(m, 3 H), 6.49(d, J = 5.4 Hz, 1 H),
3.97(s, 2 H), 3.94(s, 6 H) 96 528[M + H]+ (DMSO-d6, 400 MHz):
.delta. 12.38(br, 1 H), Ex. 2 11.88(br, 1 H), 8.51(d, J = 4.9 Hz, 1
H), 8.02-7.99(m, 1 H), 7.53-7.19(m, 7 H), 6.50(d, J = 5.1 Hz, 1 H),
3.94(s, 8 H) 97 561[M + H]+ (DMSO-d6, 400 MHz): .delta. 12.33(br, 1
H), Ex. 2 11.85(br, 1 H), 8.52(d, J = 4.9 Hz, 1 H), 8.06-7.93(m, 4
H), 7.63-7.43(m, 4 H), 6.48(d, J = 5.1 Hz, 1 H), 3.94(s, 8 H) 98
##STR00311## ND.sup.c (CDCl3, 400 MHz): .delta. 3.64(s, 2 H),
4.04(s, 3 H), 4.05(s, 3 H), 6.53(d, J = 5.1Hz, 1 H), 6.87-6.94(m, 2
H), 6.98-7.04(m, 2 H), 7.43(s, 1 H), 7.49(s, 1 H),8.16-8.24(m, 1
H), 8.31-8.37(m, 1 H),8.52(d, J = 5.4 Hz, 1 H), 8.81(br,1 H),
9.04(br, 1 H) Ex. 6 99 ##STR00312## ND.sup.c (CDCl3, 400 MHz):
.delta. 3.62(s, 2 H), 4.05(s, 3 H), 4.06(s, 3 H), 6.40(d, J =5.1
Hz, 1 H), 6.87-6.96(m, 2 H), 7.20-7.34(m, 2 H), 7.43(s, 1 H),
7.58(s,1 H), 7.76-7.82(m, 1 H), 8.10-8.18(m,1 H), 8.49(d, J = 5.4
Hz, 1 H), 8.72(br, 1 H), 9.38(br, 1 H) Ex. 6 100 ##STR00313## 458[M
+ H]+ (DMSO-d6, 400 MHz): .delta. 3.49(s, 2 H),3.92(s, 3 H),
3.93(s, 3 H), 6.44(d, J =5.4 Hz, 1 H), 7.04-7.08(m, 1 H), 7.24(d, J
= 9.0 Hz, 2 H), 7.28-7.34(m, 2 H),7.38(s, 1 H), 7.50(s, 1 H),
7.61(d, J =7.6 Hz, 2 H), 7.74(d, J = 9.0 Hz,2 H), 8.45(d, J = 5.4
Hz, 1 H), 10.19(s, 1 H), 10.34(s, 1 H) Ex. 5 101 ##STR00314## 478[M
+ H]+ (CDCl3, 400 MHz): .delta. 1.24-2.04(m, 12 H),3.30(s, 2 H),
3.90-4.01(m, 1 H), 4.05(s, 6 H), 6.45(d, J = 5.4 Hz, 1
H),7.14-71.7(m, 2 H), 7.42(s, 1 H), 7.55(s, 1 H), 7.65-7.68(m, 2
H), 8.48(d, J =5.1 Hz, 1 H) Ex. 5 102 ##STR00315## ND.sup.c (CDCl3,
400 MHz): .delta. 3.60(s, 2 H), 4.05(s, 3 H), 4.06(s, 3 H), 6.47(d,
J = 5.4Hz, 1 H), 6.88-6.94(m, 2 H), 7.18(d, J =9.0 Hz, 2 H),
7.45(s, 1 H), 7.55(s,1 H), 7.68(d, J = 9.0 Hz, 2 H), 8.14-8.20(m, 1
H), 8.49(d, J = 5.4 Hz, 1 H),8.78(br, 1 H), 8.91(br, 1 H) Ex. 5 103
##STR00316## 524[M + H]+ (CDCl3, 400 MHz): .delta. 3.81(s, 3 H),
4.05(s, 3 H), 4.07(s, 3 H), 4.50(s, 1 H),6.48(d, J = 5.6 Hz, 1 H),
6.87-6.94(m,2 H), 7.19(d, J = 9.0 Hz, 2 H), 7.52(s,1 H), 7.55(s, 1
H), 7.70(d, J = 9.0 Hz,2 H), 8.21-8.29(m, 1 H), 8.48(d, J =5.6 Hz,
1 H), 8.79(br, 1 H), 8.93(br,1 H) Ex. 15 104 ##STR00317## 522[M +
H]+ (CDCl3, 400 MHz): .delta. 1.73(s, 6 H), 4.05(s, 3 H), 4.05(s, 3
H), 6.44(d, J = 5.1Hz, 1 H), 6.87-6.94(m, 2 H), 7.18(d, J =9.0 Hz,
2 H), 7.43(s, 1 H), 7.55(s,1 H), 7.65(d, J = 9.0 Hz, 2 H),
8.14-8.21(m, 1 H), 8.48(d, J = 5.1 Hz, 1 H),8.56(br, 1 H), 8.70(br,
1 H) Ex. 15 105 ##STR00318## 472[M - H]- (CDCl3, 400 MHz): .delta.
2.37(s, 3 H), 4.06(s, 6 H), 6.49(d, J = 5.1 Hz, 1 H), 6.88(d, J =
5.1 Hz, 1 H), 7.2(m, 2 H), 7.43(s, 1 H), 7.58(s, 1 H), 7.7(m, 2 H),
8.2(m, 2 H), 8.49(d, J = 5.2 Hz, 1 H) Ex. 10 106 462[M + H]+
(CDCl3, 400 MHz): .delta. 8.43(d, 1 H, J = Ex. 10.sup.b 5.1 Hz),
7.82-7.79(m, 1 H), 7.49-7.08 (m, 12 H), 6.36(d, 1 H, J = 5.1 Hz),
3.95(s, 3 H), 3.75(s, 2 H) Ex. No. Compound structure Starting
compound A 107 ##STR00319## ##STR00320## 108 ##STR00321##
##STR00322## 109 ##STR00323## ##STR00324## 110 ##STR00325##
##STR00326## 111 ##STR00327## ##STR00328## 112 ##STR00329##
##STR00330## 113 ##STR00331## ##STR00332## 114 ##STR00333##
##STR00334## 115 ##STR00335## ##STR00336## 116 ##STR00337##
##STR00338## 117 ##STR00339## ##STR00340## 118 ##STR00341##
##STR00342## 119 ##STR00343## ##STR00344## 120 ##STR00345##
##STR00346## 121 ##STR00347## ##STR00348## 122 ##STR00349##
##STR00350## 123 ##STR00351## ##STR00352## 124 ##STR00353##
##STR00354## 125 ##STR00355## ##STR00356## 126 ##STR00357##
##STR00358## 127 ##STR00359## ##STR00360## 128 ##STR00361##
##STR00362## 129 ##STR00363## ##STR00364## 130 ##STR00365##
##STR00366## 131 ##STR00367## ##STR00368## 132 ##STR00369##
##STR00370## 133 ##STR00371## ##STR00372## 134 ##STR00373##
##STR00374## 135 ##STR00375## ##STR00376## 136 ##STR00377##
##STR00378## 137 ##STR00379## ##STR00380## 138 ##STR00381##
##STR00382## 139 ##STR00383## ##STR00384## 140 ##STR00385##
##STR00386## 141 ##STR00387## ##STR00388##
142 ##STR00389## ##STR00390## 143 ##STR00391## ##STR00392## 144
##STR00393## ##STR00394## 145 ##STR00395## ##STR00396## 146
##STR00397## ##STR00398## 147 ##STR00399## ##STR00400## 148
##STR00401## ##STR00402## 149 ##STR00403## ##STR00404## 150
##STR00405## ##STR00406## 151 ##STR00407## ##STR00408## 152
##STR00409## ##STR00410## 153 ##STR00411## ##STR00412## 154
##STR00413## ##STR00414## 155 ##STR00415## ##STR00416## 156
##STR00417## ##STR00418## 157 ##STR00419## ##STR00420## 158
##STR00421## ##STR00422## 159 ##STR00423## ##STR00424## 160
##STR00425## ##STR00426## 161 ##STR00427## ##STR00428## 162
##STR00429## ##STR00430## 163 ##STR00431## ##STR00432## 164
##STR00433## ##STR00434## 165 ##STR00435## ##STR00436## 166
##STR00437## ##STR00438## 167 ##STR00439## ##STR00440## 168
##STR00441## ##STR00442## 169 ##STR00443## ##STR00444## 170
##STR00445## ##STR00446## 171 ##STR00447## ##STR00448## 172
##STR00449## ##STR00450## 173 ##STR00451## ##STR00452## 174
##STR00453## ##STR00454## 175 ##STR00455## ##STR00456## 176
##STR00457## ##STR00458## 177 ##STR00459## ##STR00460## 178
##STR00461## ##STR00462## 179 ##STR00463## ##STR00464## 180
##STR00465## ##STR00466## 181 ##STR00467## ##STR00468## 182
##STR00469## ##STR00470## 183 ##STR00471## ##STR00472## 184
##STR00473## ##STR00474## 185 ##STR00475## ##STR00476## 186
##STR00477## ##STR00478## 187 ##STR00479## ##STR00480## 188
##STR00481## ##STR00482## 189 ##STR00483## ##STR00484## 190
##STR00485## ##STR00486## 191 ##STR00487## ##STR00488## 192
##STR00489## ##STR00490## 193 ##STR00491## ##STR00492## 194
##STR00493## ##STR00494## 195 ##STR00495## ##STR00496## 196
##STR00497## ##STR00498## 197 ##STR00499## ##STR00500## 198
##STR00501## ##STR00502## 199 ##STR00503## ##STR00504## 200
##STR00505## ##STR00506## 201 ##STR00507## ##STR00508## 202
##STR00509## ##STR00510## 203 ##STR00511## ##STR00512## 204
##STR00513## ##STR00514## 205 ##STR00515## ##STR00516## 206
##STR00517## ##STR00518## 207 ##STR00519## ##STR00520## 208
##STR00521## ##STR00522## 209 ##STR00523## ##STR00524## 210
##STR00525## ##STR00526## 211 ##STR00527## ##STR00528## 212
##STR00529## ##STR00530## 213 ##STR00531## ##STR00532## 214
##STR00533## ##STR00534## 215 ##STR00535## ##STR00536## 216
##STR00537## ##STR00538## 217 ##STR00539## ##STR00540## 218
##STR00541## ##STR00542## 219 ##STR00543## ##STR00544## 220
##STR00545## ##STR00546## 221 ##STR00547## ##STR00548## 222
##STR00549## ##STR00550## 223 ##STR00551## ##STR00552## 224
##STR00553## ##STR00554## 225 ##STR00555## ##STR00556## 226
##STR00557## ##STR00558## 227 ##STR00559## ##STR00560## 228
##STR00561## ##STR00562## 229 ##STR00563## ##STR00564## 230
##STR00565## ##STR00566## 231 ##STR00567## ##STR00568## 232
##STR00569## ##STR00570## 233 ##STR00571## ##STR00572## 234
##STR00573## ##STR00574## 235 ##STR00575## ##STR00576## 236
##STR00577## ##STR00578## 237 ##STR00579## ##STR00580## 238
##STR00581## ##STR00582## 239 ##STR00583## ##STR00584## 240
##STR00585## ##STR00586## 241 ##STR00587## ##STR00588## 242
##STR00589## ##STR00590## 243 ##STR00591## ##STR00592## 244
##STR00593## ##STR00594## 245 ##STR00595## ##STR00596## 246
##STR00597## ##STR00598## 247 ##STR00599## ##STR00600## 248
##STR00601## ##STR00602## 249 ##STR00603## ##STR00604## 250
##STR00605## ##STR00606## 251 ##STR00607## ##STR00608## 252
##STR00609## ##STR00610## 253 ##STR00611## ##STR00612## 254
##STR00613## ##STR00614## 255 ##STR00615## ##STR00616## 256
##STR00617## ##STR00618## 257 ##STR00619## ##STR00620## 258
##STR00621## ##STR00622## 259 ##STR00623## ##STR00624## 260
##STR00625## ##STR00626## 261 ##STR00627## ##STR00628## 262
##STR00629## ##STR00630## 263 ##STR00631## ##STR00632## 264
##STR00633## ##STR00634## 265 ##STR00635## ##STR00636## 266
##STR00637## ##STR00638##
267 ##STR00639## ##STR00640## Ex. Mass spectrometric No. Starting
compound B Starting compound C value (m/z) Synthesis method.sup.a
107 ##STR00641## 496[M + H]+ Ex. 3 108 ##STR00642## 476[M + H]+ Ex.
3 109 ##STR00643## 458[M + H]+ Ex. 3 110 ##STR00644## ##STR00645##
487[M + H]+ Ex. 8 111 ##STR00646## ##STR00647## 485[M + H]+ Ex. 8
112 ##STR00648## ##STR00649## 487[M + H]+ Ex. 8 113 ##STR00650##
##STR00651## 496[M + H]+ Ex. 7 114 ##STR00652## ##STR00653## 514[M
+ H]+ Ex. 7 115 ##STR00654## ##STR00655## 514[M + H]+ Ex. 7 116
##STR00656## ##STR00657## 516[M + H]+ Ex. 7 117 ##STR00658##
##STR00659## 488[M + H]+ Ex. 8 118 ##STR00660## 463[M + H]+ Ex. 3
119 ##STR00661## ##STR00662## 545[M + H]+ Ex. 8 120 ##STR00663##
##STR00664## 573[M + H]+ Ex. 8 121 ##STR00665## ##STR00666## 517[M
+ H]+ Ex. 8 122 ##STR00667## ##STR00668## 517[M + H]+ Ex. 8 123
##STR00669## ##STR00670## 483[M + H]+ Ex. 8 124 ##STR00671## 490[M
+ H]+ Ex. 3 125 ##STR00672## 476[M + H]+ Ex. 3 126 ##STR00673##
494[M + H]+ Ex. 3 127 ##STR00674## 494[M + H]+ Ex. 3 128
##STR00675## 511[M + H]+ Ex. 3 129 ##STR00676## ##STR00677## 490[M
+ H]+ Ex. 7 130 ##STR00678## ##STR00679## 528[M + H]+ Ex. 7 131
##STR00680## ##STR00681## 517[M + H]+ Ex. 8 132 ##STR00682## 512[M
+ H]+ Ex. 3 133 ##STR00683## 512[M + H]+ Ex. 3 134 ##STR00684##
512[M + H]+ Ex. 3 135 ##STR00685## 512[M + H]+ Ex. 3 136
##STR00686## 544[M + H]+ Ex. 3 137 ##STR00687## 544[M + H]+ Ex. 3
138 ##STR00688## 512[M + H]+ Ex. 3 139 ##STR00689## 512[M + H]+ Ex.
3 140 ##STR00690## 512[M + H]+ Ex. 3 141 ##STR00691## 512[M + H]+
Ex. 3 142 ##STR00692## 512[M + H]+ Ex. 3 143 ##STR00693## 470[M +
H]+ Ex. 2 144 ##STR00694## 508[M + H]+ Ex. 2 145 ##STR00695## 528[M
+ H]+ Ex. 2 146 ##STR00696## 557[M + H]+ Ex. 2 147 ##STR00697##
476[M + H]+ Ex. 1 148 ##STR00698## 478[M + H]+ Ex. 1 149
##STR00699## 522[M + H]+ Ex. 2 150 ##STR00700## 500[M + 1]+ Ex. 2
151 ##STR00701## 492[M + H]+ Ex. 2 152 ##STR00702## 526[M + H]+ Ex.
2 153 ##STR00703## 504[M + 1]+ Ex. 2 154 ##STR00704## 539[M + 1]+
Ex. 2 155 ##STR00705## 519[M + 1]+ Ex. 2 156 ##STR00706## 553[M +
1]+ Ex. 2 157 ##STR00707## 524[M + 1]+ Ex. 2 158 ##STR00708## 488[M
+ 1]+ Ex. 2 159 ##STR00709## 490[M + 1]+ Ex. 2 160 ##STR00710##
480[M + 1]+ Ex. 2 161 ##STR00711## 480[M + 1]+ Ex. 1 162
##STR00712## 488[M + H]+ Ex. 1 163 ##STR00713## 502[M + H]+ Ex. 1
164 ##STR00714## 492[M + H]+ Ex. 2 165 ##STR00715## 474[M + H]+ Ex.
2 166 ##STR00716## 498[M + H]+ Ex. 2 167 ##STR00717## 488[M + H]+
Ex. 2 168 ##STR00718## 488[M + H]+ Ex. 2 169 ##STR00719## 522[M +
H]+ Ex. 2 170 ##STR00720## 506[M + H]+ Ex. 2 171 ##STR00721## 508[M
+ H]+ Ex. 2 172 ##STR00722## 526[M + H]+ Ex. 2 173 ##STR00723##
526[M + H]+ Ex. 2 174 ##STR00724## 542[M + H]+ Ex. 2 175
##STR00725## 506[M + H]+ Ex. 2 176 ##STR00726## 506[M + H]+ Ex. 2
177 ##STR00727## 468[M + H]+ Ex. 2 178 ##STR00728## 486[M + H]+ Ex.
2 179 ##STR00729## 486[M + H]+ Ex. 2 180 ##STR00730## 476[M + H]+
Ex. 2 181 ##STR00731## 522[M + H]+ Ex. 2 182 ##STR00732## 526[M +
H]+ Ex. 2 183 ##STR00733## 543[M + H]+ Ex. 2 184 ##STR00734## 504[M
+ H]+ Ex. 2 185 ##STR00735## 522[M + H]+ Ex. 2 186 ##STR00736##
539[M + H]+ Ex. 2 187 ##STR00737## 508[M + H]+ Ex. 2 188
##STR00738## 526[M + H]+ Ex. 2 189 ##STR00739## 543[M + H]+ Ex. 2
190 ##STR00740## 506[M + H]+ Ex. 2 191 ##STR00741## 512[M + H]+ Ex.
2 192 ##STR00742## 512[M + H]+ Ex. 2 193 ##STR00743## 505[M + H]+
Ex. 2 194 ##STR00744## 528[M + H]+ Ex. 2 195 ##STR00745## 528[M +
H]+ Ex. 2 196 ##STR00746## 528[M + H]+ Ex. 2 197 ##STR00747## 528[M
+ H]+ Ex. 2 198 ##STR00748## 528[M + H]+ Ex. 2 199 ##STR00749##
528[M + H]+ Ex. 2 200 ##STR00750## 560[M + H]+ Ex. 2 201
##STR00751## 560[M + H]+ Ex. 2 202 ##STR00752## 560[M + H]+ Ex. 2
203 ##STR00753## 560[M + H]+ Ex. 2 204 ##STR00754## 528[M + H]+ Ex.
2 205 ##STR00755## 546[M + H]+ Ex. 2 206 ##STR00756## 546[M + H]+
Ex. 2 207 ##STR00757## 562[M + H]+ Ex. 2 208 ##STR00758## 561[M +
H]+ Ex. 2 209 ##STR00759## ##STR00760## 438[M + H]+ Ex. 5 210
##STR00761## ##STR00762## 492[M + H]+ Ex. 5 211 ##STR00763##
##STR00764## 488[M + H]+ Ex. 5 212 ##STR00765## ##STR00766## 436[M
+ H]+ Ex. 5 213 ##STR00767## ##STR00768## 516[M + H]+ Ex. 5 214
##STR00769## ##STR00770## 486[M + H]+ Ex. 5 215 ##STR00771##
##STR00772## 472[M + H]+ Ex. 5 216 ##STR00773## ##STR00774## 472[M
+ H]+ Ex. 5 217 ##STR00775## ##STR00776## 464[M + H]+ Ex. 5 218
##STR00777## ##STR00778## 478[M + H]+ Ex. 5 219 ##STR00779##
##STR00780## 492[M + H]+ Ex. 5 220 ##STR00781## ##STR00782## 474[M
+ H]+ Ex. 5 221 ##STR00783## ##STR00784## 466[M + H]+ Ex. 5 222
##STR00785## ##STR00786## 528[M + H]+ Ex. 6 223 ##STR00787##
##STR00788## 508[M + H]+ Ex. 6 224 ##STR00789## ##STR00790## 522[M
+ H]+ Ex. 6 225 ##STR00791## ##STR00792## 472[M + H]+ Ex. 15 226
##STR00793## ##STR00794## 478[M + H]+ Ex. 15 227 ##STR00795##
##STR00796## 459[M + H]+ Ex. 5 228 ##STR00797## ##STR00798## 486[M
+ H]+ Ex. 15 229 ##STR00799## ##STR00800## 493[M - H]- Ex. 9
230 ##STR00801## ##STR00802## 550[M - H]- Ex. 9 231 ##STR00803##
##STR00804## 492[M - H]- Ex. 9 232 ##STR00805## ##STR00806## 462[M
- H]- Ex. 9 233 ##STR00807## ##STR00808## 472[M - H]- Ex. 9 234
##STR00809## ##STR00810## 472[M - H]- Ex. 9 235 ##STR00811##
##STR00812## 472[M - H]- Ex. 9 236 ##STR00813## ##STR00814## 458[M
- H]- Ex. 9 237 ##STR00815## ##STR00816## 461[M - H]- Ex. 9 238
##STR00817## ##STR00818## 515[M - H]- Ex. 9 239 ##STR00819##
##STR00820## 482[M - H]- Ex. 9 240 ##STR00821## ##STR00822## 525[M
- H]- Ex. 9 241 ##STR00823## ##STR00824## 496[M - H]- Ex. 9 242
##STR00825## ##STR00826## 505[M - H]- Ex. 9 243 ##STR00827##
##STR00828## 497[M - H]- Ex. 9 244 ##STR00829## ##STR00830## 487[M
- H]- Ex. 9 245 ##STR00831## ##STR00832## 515[M - H]- Ex. 9 246
##STR00833## ##STR00834## 547[M - H]- Ex. 9 247 ##STR00835##
##STR00836## 535[M - H]- Ex. 9 248 ##STR00837## ##STR00838## 491[M
- H]- Ex. 9 249 ##STR00839## ##STR00840## 491[M - H]- Ex. 9 250
##STR00841## ##STR00842## 509[M - H]- Ex. 9 251 ##STR00843##
##STR00844## 475[M - H]- Ex. 9 252 ##STR00845## ##STR00846## 475[M
- H]- Ex. 9 253 ##STR00847## ##STR00848## 503[M - H]- Ex. 9 254
##STR00849## ##STR00850## 502[M - H]- Ex. 9 255 ##STR00851##
##STR00852## 549[M - H]- Ex. 9 256 ##STR00853## ##STR00854## 471[M
- H]- Ex. 9 257 ##STR00855## ##STR00856## 571[M - H]- Ex. 9 258
##STR00857## ##STR00858## 485[M - H]- Ex. 9 259 ##STR00859##
##STR00860## 522[M - H]- Ex. 9 260 ##STR00861## ##STR00862## 508[M
- H]- Ex. 9 261 ##STR00863## ##STR00864## 499[M - H]- Ex. 9 262
##STR00865## ##STR00866## 508[M - H]- Ex. 9 263 ##STR00867##
##STR00868## 525[M - H]- Ex. 9 264 ##STR00869## ##STR00870## 493[M
- H]- Ex. 9 265 ##STR00871## ##STR00872## 493[M - H]- Ex. 9 266
##STR00873## ##STR00874## 487[M - H]- Ex. 9 267 ##STR00875##
##STR00876## 501[M - H]- Ex. 9 .sup.aSynthesized as in Examples
described below. .sup.bSynthesized as described in indicated
Synthesis Example. .sup.cNo data
Example 277
1-{3-Fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-phe-
nyl}-3-[2-(4-fluorophenyl)-acetyl]-thiourea
1) Synthesis of
3-fluoro-4-[(7-(3-bromoethyl)-6-methoxy-4-quinolyl)oxy]aniline)
[0580] 3-Fluoro-4-[(7-benzyloxy-6-methoxy-4-quinolyl)-oxy]aniline
(7.8 g), together with trifluoroacetic acid (80 ml) and
methanesulfonic acid (1 ml), was stirred at 80.degree. C. for 2 hr.
After the removal of the solvent by evaporation, the residue was
neutralized with an aqueous saturated sodium hydrogencarbonate
solution, and the precipitated crystal was collected by suction
filtration to give a crude crystal (8.8 g) (starting compound A).
This crude crystal (5 g) was dissolved in dimethylformamide (120
ml). Potassium carbonate (9.2 g) and dibromoethane (12.5 g)
(starting compound C) were added to the solution, and the mixture
was stirred at room temperature for about 90 hr. The reaction
solution was filtered through Celite, and the solvent was removed
from the filtrate by evaporation under the reduced pressure. The
residue was purified by column chromatography on silica gel
[chloroform:methanol] to give
3-fluoro-4-[(7-(3-bromoethyl)-6-methoxy-4-quinolyl)oxy]aniline)
(1.88 g, yield 29%).
2) Synthesis of
1-{3-fluoro-4-[7-(3-bromoethyl)-6-methoxy-quinolin-4-yloxy]-phenyl}-3-[2--
(4-fluoro-phenyl)-acetyl]-thiourea
[0581] 4-Fluorophenylacetic acid (2.37 g) (starting compound D) was
dissolved in thionyl chloride (8 ml) to prepare a solution which
was then stirred at 40.degree. C. for one hr. The solvent was
removed by evaporation under the reduced pressure. Acetonitrile
(300 ml) was added to the residue to dissolve the residue.
Potassium thiocyanate (1.87 g) was added to the solution, and the
mixture was stirred at 40.degree. C. for 50 min. The solvent was
removed by evaporation under the reduced pressure. Ethyl acetate
(50 ml) and an aqueous saturated sodium hydrogencarbonate solution
(50 ml) were added to the residue, and the mixture was stirred at
room temperature for 10 min. The reaction solution was filtered
through Celite, and the filtrate was extracted with ethyl acetate,
followed by washing with saturated brine. The extract was dried
over anhydrous sodium sulfate. The solvent was removed by
evaporation under the reduced pressure. The residue was dissolved
in ethanol:toluene (1:1=10 ml).
3-Fluoro-4-[(7-(3-bromoethyl)-6-methoxy-4-quinolyl)oxy]aniline (1.4
g) synthesized in step 1) was added to the solution, and the
mixture was stirred at room temperature for 18 hr. The precipitated
crystal was collected by filtration to give the title compound
(1.58 g, yield 73%).
[0582] .sup.1H-NMR (DMSO, 400 MHz): .delta. 3.85 (s, 2H), 3.96 (t,
J=5.4 Hz, 2H), 4.06 (s, 3H), 4.62 (t, J=5.4 Hz, 2H), 6.98 (d, J=6.3
Hz, 1H), 7.15-7.23 (m, 2H), 7.37-7.43 (m, 2H), 7.55 (s, 1H),
7.60-7.68 (m, 1H), 7.79 (s, 1H), 8.15-8.18 (m, 1H), 8.85 (d, J=6.3
Hz, 1H), 11.86 (s, 1H), 12.54 (s, 1H)
3) Synthesis of
1-{3-fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(4-fluorophenyl)-acetyl]-thiourea (Example 277)
[0583] Dimethylformamide (3 ml) was added to the compound (200 mg)
prepared in step 2) to dissolve the compound. Morpholine (29 mg)
(starting compound B) and potassium carbonate (46 mg) were added to
the solution, and the mixture was stirred at room temperature for
18 hr. Ethyl acetate:water was added thereto, and the mixture was
extracted with ethyl acetate, followed by washing with saturated
brine. The extract was dried over anhydrous sodium sulfate. The
solvent was removed by evaporation under the reduced pressure. The
residue was purified by TLC preparation [chloroform:methanol] to
give the title compound (Example 277) (92 mg, yield 46%).
[0584] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.89 (s, 4H),
2.95 (s, 4H), 3.73 (s, 2H), 3.73-3.78 (m, 2H), 4.03 (s, 3H), 4.34
(t, J=6.1 Hz, 2H), 6.43 (d, J=5.1 Hz, 1H), 7.12 (t, J=8.8 Hz, 1H),
7.23-7.32 (m, 6H), 7.43 (s, 1H), 7.94 (dd, J=2.4, 11.5 Hz, 1H),
8.50 (d, J=5.1 Hz, 1H), 8.66 (br, 1H), 12.44 (s, 1H)
[0585] ESI-MS: m/z=607 (M-1)
Example 285
1-[2-(2-Chloro-phenyl)-acetyl]-3-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-y-
l-propoxy)-quinolin-4-yloxy]-phenyl}-thiourea
[0586] 2-Chlorophenylacetic acid (96 mg) (starting compound D) was
dissolved in thionyl chloride (0.5 ml) to prepare a solution which
was then stirred at 40.degree. C. for one hr. The solvent was
removed by evaporation under the reduced pressure. Acetonitrile (30
ml) was added to the residue to dissolve the residue. Potassium
thiocyanate (68 mg) was added to the solution, and the mixture was
stirred at 40.degree. C. for 50 min. The solvent was removed by
evaporation under the reduced pressure. Ethyl acetate (15 ml) and
an aqueous saturated sodium hydrogencarbonate solution (15 ml) were
added to the residue, and the mixture was stirred at room
temperature for 20 min. The reaction solution was extracted with
ethyl acetate, followed by washing with saturated brine. The
extract was dried over anhydrous sodium sulfate. The solvent was
removed by evaporation under the reduced pressure. The residue was
dissolved in ethanol:toluene (1:1=6 ml). Starting compound 12 (60
mg) (starting compound A) was added to the solution, and the
mixture was stirred at room temperature for 18 hr. The solvent was
removed by evaporation under the reduced pressure, and the residue
was purified by TLC preparation [chloroform:methanol] to give the
title compound (44 mg, yield 49%).
[0587] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.10-2.18 (m,
2H), 2.47-2.54 (m, 4H), 2.59 (t, J=7.2 Hz, 2H), 3.73 (t, J=4.5 Hz,
4H), 3.89 (s, 2H), 4.03 (s, 3H), 4.28 (t, J=6.7 Hz, 2H), 6.44 (dd,
J=1.0, 5.4 Hz, 1H), 7.31-7.52 (m, 6H), 7.54 (s, 1H), 7.95 (dd,
J=2.4, 11.5 Hz, 1H), 8.50 (d, J=5.4 Hz, 1H), 8.64 (s, 1H), 12.42
(s, 1H)
[0588] ESI-MS: m/z 639 (M+1), 637 (M-1)
Example 287
1-{2-Fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-phenyl-acetyl-urea
1) Synthesis of
2-fluoro-4-[(7-(3-chloropropyl)-6-methoxy-4-quinolyl)oxy]aniline)
[0589] 2-Fluoro-4-[(7-benzyloxy-6-methoxy-4-quinolyl)-oxy]aniline
(4.2 g) (starting compound 2), together with trifluoroacetic acid
(20 ml) and methanesulfonic acid (1 ml), was heated under reflux
for one hr. The solvent was removed by evaporation, and the residue
was then neutralized with a 10% aqueous sodium hydroxide solution.
The precipitated crystal was collected by suction filtration to
give a crude crystal (3.8 g) (starting compound A). This crude
crystal (2 g) was dissolved in dimethylformamide (80 ml). Potassium
carbonate (4.9 g) and 1-bromo-3-chloro-propane (5.6 g) (starting
compound C) were added to the solution, and the mixture was stirred
at room temperature for 16 hr. The reaction solution was extracted
with ethyl acetate, followed by washing with saturated brine. The
extract was dried over anhydrous sodium sulfate, and the solvent
was removed by evaporation under the reduced pressure. The residue
was purified by column chromatography on silica gel, and the title
compound (1.65 g, yield 77%) was obtained from the fraction of
chloroform:methanol (99:1).
[0590] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.36-2.43 (m,
2H), 3.75 (s, 2H), 3.79-3.83 (m, 2H), 3.96 (s, 3H), 4.32-4.36 (m,
2H), 6.44 (d, J=5.3 Hz, 1H), 6.80-6.92 (m, 3H), 7.43 (s, 1H), 7.52
(s, 1H), 8.48 (d, J=5.3 Hz, 1H)
2) Synthesis of
2-fluoro-4-[(6-methoxy-7-(3-morpholinopropyl)-4-quinolyl)oxy]aniline
[0591] The aniline compound (0.7 g) prepared in step 1) was
dissolved in dimethylformamide (40 ml) to prepare a solution.
Potassium carbonate (1.4 g), sodium iodide (0.6 g) and morpholine
(0.85 g) (starting compound B) were added to the solution, and the
mixture was stirred at 70.degree. C. for 20 hr. The reaction
solution was extracted with ethyl acetate, followed by washing with
saturated brine. The extract was dried over anhydrous sodium
sulfate, and the solvent was removed by evaporation under the
reduced pressure. The residue was purified by column chromatography
on silica gel, and the title compound (0.64 g, yield 76%) was
obtained from the fraction of chloroform:methanol (95:5).
[0592] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.01-2.11 (m,
2H), 2.37-2.50 (m, 4H), 2.44-2.57 (m, 2H), 3.64-3.74 (m, 4H), 3.67
(s, 2H), 3.95 (s, 3H), 4.13-4.22 (m, 2H), 6.36 (d, J=5.4 Hz, 1H),
6.73-6.84 (m, 3H), 7.35 (s, 1H), 7.46 (s, 1H), 8.40 (d, J=5.4 Hz,
1H)
3) Synthesis of
1-{2-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-phenyl-acetyl-urea (Example 287)
[0593] Phenylacetamide (95 mg) (starting compound D) was suspended
in anhydrous dichloroethane (10 ml). Oxalyl chloride (0.09 ml) was
added to the suspension, and the mixture was heated under reflux
for 17 hr. The solvent was removed by evaporation under the reduced
pressure to give a crude crystal. The crude crystal was suspended
in anhydrous chloroform (10 ml). The suspension was added at room
temperature to a solution of the aniline compound (100 mg) prepared
in step 2) and triethylamine (330 mg) in anhydrous chloroform (10
ml), and the mixture was stirred at room temperature for 5 hr. A 2%
aqueous sodium hydroxide solution was added thereto, and the
chloroform layer was separated. The separated chloroform layer was
dried over anhydrous sodium sulfate. The solvent was removed by
evaporation under the reduced pressure. The residue was purified by
column chromatography on silica gel, and the title compound
(Example 287) (115 mg, yield 84%) was obtained from the fraction of
chloroform:methanol (97:3).
[0594] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.07-2.15 (m,
2H), 2.44-2.51 (m, 4H), 2.55 (t, J=7.0 Hz, 2H), 3.69-3.75 (m, 4H),
3.75 (s, 2H), 3.98 (s, 3H), 4.24 (t, J=6.5 Hz, 2H), 6.48 (d, J=5.1
Hz, 1H), 6.94-7.00 (m, 4H), 7.24-7.40 (m, 5H), 7.36 (s, 1H), 7.40
(s, 1H), 8.18 (t, J=8.8 Hz, 1H), 8.48 (d, J=5.1 Hz, 1H), 8.49 (s,
1H), 10.76 (s, 1H)
[0595] Mass spectrometric value (ESI-MS, m/z): 589 (M.sup.++1)
Example 313
1-{3-Fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-[2-(4-fluorophenyl)-acetyl]-thiourea
1) Synthesis of
1-{[4-(4-aminophenoxy)-6-methoxy-7-quinolyl]oxy}-3-morpholino-2-propanol
[0596] Starting compound 2 (10 g), together with trifluoroacetic
acid (100 ml) and methanesulfonic acid (1 ml), was heated under
reflux for one hr. The temperature of the reaction solution was
returned to room temperature, and the solvent was removed by
evaporation. The residue was then made weakly alkaline with an
aqueous saturated sodium hydrogencarbonate solution to precipitate
a solid. The solid was collected by filtration, was washed with
water, and was then dried to give a crude crystal (9.6 g) (starting
compound A). Dimethylformamide (300 ml) was added to the crude
crystal to dissolve the crystal. Potassium carbonate (23.5 g) and
epibromohydrin (3.1 ml) (starting compound C) were then added to
the solution, and the mixture was stirred at room temperature
overnight. Further, potassium carbonate (2.3 g) and epibromohydrin
(0.3 ml) (starting compound C) were added thereto, and the mixture
was stirred at room temperature overnight. Morpholine (14.8 ml)
(starting compound B) was added thereto, and the mixture was
stirred at 70.degree. C. overnight. The temperature of the reaction
solution was returned to room temperature, and water was added
thereto. The mixture was then extracted with ethyl acetate. The
organic layer was washed with saturated brine and was dried over
sodium sulfate, and the dried organic layer was then concentrated.
The residue was purified by column chromatography on silica gel
using chloroform:methanol for development to give 6.9 g of the
title compound.
[0597] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.48-2.54 (m,
2H), 2.62-2.64 (m, 2H), 2.67-2.73 (m, 2H), 3.52 (brs, 1H),
3.73-3.76 (m, 4H), 3.82 (brs, 2H), 4.16-4.23 (m, 2H), 4.26-4.32 (m,
1H), 6.42 (dd, J=1.0, 5.4 Hz, 1H), (ddd, J=1.0, 2.7, 8.5 Hz, 1H),
6.57 (dd, J=2.7, Hz, 1H), 7.04 (t, J=8.5 Hz, 1H), 7.45 (s, 1H), (s,
1H), 8.47 (d, J=5.4 Hz, 1H)
[0598] Mass spectrometric value (ESI-MS, m/z): 442 (M.sup.+-1)
2)
1-{3-Fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinoli-
n-4-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea (Example
313)
[0599] 4-Fluorophenylacetic acid (4.3 g) (starting compound D) was
added to thionyl chloride (10 ml). The mixture was stirred at
40.degree. C. for one hr and was then concentrated, and the residue
was then dried by means of a vacuum pump. Acetonitrile (250 ml) was
added thereto, and potassium isothiocyanate (3.4 g) was added to
the mixture. The mixture was stirred at 40.degree. C. for 50 min,
followed by concentration. An aqueous saturated sodium
hydrogencarbonate solution was added to the concentrate, and the
mixture was extracted with ethyl acetate. The organic layer was
washed with saturated brine and was dried over sodium sulfate, and
the solvent was then removed by evaporation. A mixed solvent
composed of toluene (50 ml) and ethanol (50 ml) was added to the
residue, and amine (3.0 g) was added thereto. The mixture was
stirred at room temperature overnight. An aqueous saturated sodium
hydrogencarbonate solution was added to the reaction solution, and
the mixture was extracted with a mixed solvent composed of
chloroform and methanol. The organic layer was washed with
saturated brine and was dried over sodium sulfate. The dried
organic layer was then concentrated, and the residue was purified
by column chromatography on silica gel using chloroform:methanol
for development to give the title compound (1.4 g, yield 44%).
[0600] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.48-2.55 (m,
2H), 2.60-2.73 (m, 4H), 3.72-3.77 (m, 6H), 4.02 (s, 3H), 4.16-4.32
(m, 3H), 6.45 (d, J=4.4 Hz, 1H), 7.12 (t, J=8.5 Hz, 2H), 7.23-7.32
(m, 3H), 7.40 (d, J=8.8 Hz, 1H), 7.45 (s, 1H), 7.54 (s, 1H), 7.93
(dd, J=2.6, 11.5 Hz, 1H), 8.50 (d, J=5.4 Hz, 1H), 8.65 (s, 1H),
12.44 (s, 1H)
[0601] ESI-MS: m/z=639 (M+1)
[0602] Compounds of Examples 277, 285, 287, and 313 had the
following respective structures.
##STR00877##
[0603] Compounds of Examples 270 to 276, 278 to 284, 286, 288 to
312, and 314 to 337 were synthesized as described in Examples 277,
285, 287, and 313. For these compounds, chemical structural
formulae, starting compounds, synthesis methods, and data for
identifying the compounds are as follows.
TABLE-US-00002 Ex. Compound Starting No. structure compound A 270
##STR00878## ##STR00879## 271 ##STR00880## ##STR00881## 272
##STR00882## ##STR00883## 273 ##STR00884## ##STR00885## 275
##STR00886## ##STR00887## 276 ##STR00888## ##STR00889## 277
##STR00890## ##STR00891## 278 ##STR00892## ##STR00893## 279
##STR00894## ##STR00895## 282 ##STR00896## ##STR00897## 283
##STR00898## ##STR00899## 284 ##STR00900## ##STR00901## 286
##STR00902## ##STR00903## 288 ##STR00904## ##STR00905## 289
##STR00906## ##STR00907## 291 ##STR00908## ##STR00909## 292
##STR00910## ##STR00911## 293 ##STR00912## ##STR00913## 294
##STR00914## ##STR00915## 295 ##STR00916## ##STR00917## 296
##STR00918## ##STR00919## 297 ##STR00920## ##STR00921## 298
##STR00922## ##STR00923## 299 ##STR00924## ##STR00925## 300
##STR00926## ##STR00927## 301 ##STR00928## ##STR00929## 302
##STR00930## ##STR00931## 303 ##STR00932## ##STR00933## 304
##STR00934## ##STR00935## 305 ##STR00936## ##STR00937## 306
##STR00938## ##STR00939## 307 ##STR00940## ##STR00941## 308
##STR00942## ##STR00943## 309 ##STR00944## ##STR00945## 310
##STR00946## ##STR00947## 311 ##STR00948## ##STR00949## 312
##STR00950## ##STR00951## 314 ##STR00952## ##STR00953## 315
##STR00954## ##STR00955## 316 ##STR00956## ##STR00957## 317
##STR00958## ##STR00959## 318 ##STR00960## ##STR00961## 319
##STR00962## ##STR00963## 320 ##STR00964## ##STR00965## 321
##STR00966## ##STR00967## 322 ##STR00968## ##STR00969## 323
##STR00970## ##STR00971## 324 ##STR00972## ##STR00973## 325
##STR00974## ##STR00975## 326 ##STR00976## ##STR00977## 327
##STR00978## ##STR00979## 328 ##STR00980## ##STR00981## 329
##STR00982## ##STR00983## 330 ##STR00984## ##STR00985## 331
##STR00986## ##STR00987## 332 ##STR00988## ##STR00989## 333
##STR00990## ##STR00991## 334 ##STR00992## ##STR00993## 335
##STR00994## ##STR00995## 336 ##STR00996## ##STR00997## 337
##STR00998## ##STR00999## Ex. Starting Starting Starting Synthesis
No. compound B compound C compound D method.sup.a 270 ##STR01000##
##STR01001## ##STR01002## Ex. 277 271 ##STR01003## ##STR01004##
##STR01005## Ex. 277 272 ##STR01006## ##STR01007## ##STR01008## Ex.
277 273 ##STR01009## ##STR01010## ##STR01011## Ex. 277 275
##STR01012## ##STR01013## ##STR01014## Ex. 277 276 ##STR01015##
##STR01016## ##STR01017## Ex. 277 277 ##STR01018## ##STR01019##
##STR01020## Ex. 277 278 ##STR01021## ##STR01022## ##STR01023## Ex.
277 279 ##STR01024## ##STR01025## ##STR01026## Ex. 277 282
##STR01027## ##STR01028## ##STR01029## Ex. 277 283 ##STR01030##
##STR01031## ##STR01032## Ex. 287 284 ##STR01033## ##STR01034##
##STR01035## Ex. 277 286 ##STR01036## ##STR01037## ##STR01038## Ex.
287 288 ##STR01039## Ex. 285 289 ##STR01040## Ex. 285 291
##STR01041## ##STR01042## ##STR01043## Ex. 287 292 ##STR01044##
##STR01045## ##STR01046## Ex. 287 293 ##STR01047## ##STR01048##
##STR01049## Ex. 287 294 ##STR01050## ##STR01051## ##STR01052## Ex.
287 295 ##STR01053## ##STR01054## ##STR01055## Ex. 287 296
##STR01056## ##STR01057## ##STR01058## Ex. 287 297 ##STR01059##
##STR01060## ##STR01061## Ex. 277 298 ##STR01062## ##STR01063##
##STR01064## Ex. 277 299 ##STR01065## ##STR01066## ##STR01067## Ex.
277 300 ##STR01068## ##STR01069## ##STR01070## Ex. 277 301
##STR01071## ##STR01072## ##STR01073## Ex. 277 302 ##STR01074## Ex.
285 303 ##STR01075## Ex. 285 304 ##STR01076## Ex. 285 305
##STR01077## ##STR01078## ##STR01079## Ex. 287 306 ##STR01080##
##STR01081## ##STR01082## Ex. 287 307 ##STR01083## ##STR01084##
##STR01085## Ex. 277 308 ##STR01086## ##STR01087## ##STR01088## Ex.
287 309 ##STR01089## ##STR01090## ##STR01091## Ex. 277 310
##STR01092## ##STR01093## ##STR01094## Ex. 277 311 ##STR01095##
##STR01096## ##STR01097## Ex. 287 312 ##STR01098## ##STR01099##
##STR01100## Ex. 313 314 ##STR01101## ##STR01102## ##STR01103## Ex.
313 315 ##STR01104## ##STR01105## ##STR01106## Ex. 313 316
##STR01107## ##STR01108## ##STR01109## Ex. 313 317 ##STR01110##
##STR01111## ##STR01112## Ex. 313 318 ##STR01113## ##STR01114##
##STR01115## Ex. 313 319 ##STR01116## ##STR01117## ##STR01118## Ex.
313 320 ##STR01119## ##STR01120## ##STR01121## Ex. 313 321
##STR01122## ##STR01123## ##STR01124## Ex. 313 322 ##STR01125##
##STR01126## ##STR01127## Ex. 313 323 ##STR01128## ##STR01129##
##STR01130## Ex. 313 324 ##STR01131## ##STR01132## ##STR01133## Ex.
313 325 ##STR01134## ##STR01135## ##STR01136## Ex. 313 326
##STR01137## ##STR01138## ##STR01139## Ex. 313 327 ##STR01140##
##STR01141## ##STR01142## Ex. 313 328 ##STR01143## ##STR01144##
##STR01145## Ex. 313 329 ##STR01146## ##STR01147## ##STR01148## Ex.
313 330 ##STR01149## ##STR01150## ##STR01151## Ex. 285 331
##STR01152## ##STR01153## ##STR01154## Ex. 285 332 ##STR01155##
##STR01156## ##STR01157## Ex. 285 333 ##STR01158## ##STR01159##
##STR01160## Ex. 285 334 ##STR01161## ##STR01162## ##STR01163## Ex.
285 335 ##STR01164## ##STR01165## ##STR01166## Ex. 285 336
##STR01167## ##STR01168## ##STR01169## Ex. 287 337 ##STR01170##
##STR01171## ##STR01172## Ex. 287
Example 270
1-(3-Fluoro-4-{6-methoxy-7-[2-(4-methyl-piperazin-1-yl)-ethoxy]-quinolin-4-
-yloxy}-phenyl)-3-phenylacetyl-thiourea
[0604] .sup.1H-NMR (DMSO, 400 MHz): .delta. 2.20 (s, 3H), 2.33-2.57
(m, 8H), 2.79 (t, J=5.6 Hz, 2H), 3.83 (s, 2H), 3.94 (s, 3H), 4.26
(t, J=5.9 Hz, 2H), 6.48 (d, J=5.1 Hz, 1H), 7.23-7.57 (m, 9H), 8.01
(dd, J=2.2, 12.2 Hz, 1H), 8.49 (d, J=5.1 Hz, 1H), 11.82 (br, 1H),
12.50 (br, 1H)
[0605] ESI-MS: m/z=604 (M+1), 602 (M-1)
Example 271
1-(3-Fluoro-4-{6-methoxy-7-[2-(4-methyl-piperazin-1-yl)-ethoxy]-quinolin-4-
-yloxy}-phenyl)-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea
[0606] .sup.1H-NMR (DMSO, 400 MHz): .delta. 2.16 (s, 3H), 2.28-2.62
(m, 8H), 2.78 (t, J=5.9 Hz, 2H), 3.83 (s, 2H), 3.94 (s, 3H), 4.26
(t, J=5.9 Hz, 2H), 6.48 (dd, J=1.0, 5.1 Hz, 1H), 7.10-7.41 (m, 6H),
7.44 (s, 1H), 7.52 (s, 1H), 8.00 (dd, J=2.2, 12.2 Hz, 1H), 8.49 (d,
J=5.1 Hz, 1H), 11.81 (br, 1H), 12.47 (br, 1H)
Example 272
1-{4-[7-(2-Diethylamino-ethoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-pheny-
l}-3-phenylacetyl-thiourea
[0607] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 1.01 (t, J=7.1
Hz, 6H), 2.50-2.70 (m, 4H), 2.80-3.00 (m, 2H), 3.81 (s, 2H), 3.92
(s, 3H), 4.20 (t, J=5.9 Hz, 2H), 6.46 (d, J=5.1 Hz, 1H), 7.07-7.57
(m, 9H), 7.93-8.10 (m, 1H), 8.48 (d, J=5.1 Hz, 1H), 11.80 (s, 1H),
12.50 (s, 1H)
[0608] Mass spectrometric value (ESI-MS, m/z): 577 (M+1).sup.+
Example 273
1-(3-Fluoro-4-{6-methoxy-7-[2-(4-methyl-[1,4]diazepan-1-yl)-ethoxy]-quinol-
in-4-yloxy}-phenyl)-3-phenylacetyl-thiourea
[0609] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=20:1, 400 MHz): .delta.
1.84-1.94 (m, 2H), 2.42 (s, 3H), 2.68-2.78 (m, 4H), 2.88-2.97 (m,
4H), 3.12 (t, J=6.4 Hz, 2H), 3.76 (s, 2H), 4.02 (s, 3H), 4.29 (t,
J=6.4 Hz, 2H), 6.44 (d, J=5.1 Hz, 1H), 7.24-7.49 (m, 8H), 7.54 (s,
1H), 7.93 (dd, J=2.4, 11.7 Hz, 1H), 8.51 (d, J=5.1 Hz, 1H)
[0610] ESI-MS: m/z=618 (M+1), 616 (M-1)
Example 275
1-{4-[7-(2-Diethylamino-ethoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-pheny-
l}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea
[0611] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 1.11 (t, J=7.1
Hz, 6H), 2.66-2.74 (m, 4H), 3.02-3.08 (m, 2H), 3.73 (s, 2H), 4.02
(s, 3H), 4.29 (t, J=6.5 Hz, 2H), 6.44 (d, J=5.1 Hz, 1H), 7.09-7.46
(m, 7H), 7.53 (s, 1H), 7.93 (dd, J=2.4, 11.5 Hz, 1H), 8.50 (d,
J=5.1 Hz, 1H), 8.51 (br, 1H), 12.42 (s, 1H)
[0612] ESI-MS: m/z=595 (M+1), 593 (M-1)
Example 276
1-{3-Fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-phe-
nyl}-3-phenylacetyl-thiourea
[0613] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.62-2.72 (m,
4H), 2.98 (t, J=5.7 Hz, 2H), 3.70-3.78 (m, 6H), 4.02 (s, 3H), 4.35
(t, J=5.7 Hz, 2H), 6.46 (d, J=5.4 Hz, 1H), 7.21-7.45 (m, 8H), 7.55
(s, 1H), 7.93 (dd, J=2.4, 11.5 Hz, 1H), 8.52 (d, J=5.4 Hz, 1H),
9.33 (s, 1H), 12.57 (s, 1H)
[0614] ESI-MS: m/z=591 (M+1), 589 (M-1)
Example 278
1-{3-Fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-phe-
nyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea
[0615] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.63-2.78 (m,
4H), 2.98 (t, J=5.8 Hz, 2H), 3.75-3.82 (m, 4H), 3.80 (s, 2H), 4.03
(s, 3H), 4.37 (t, J=5.8 Hz, 2H), 6.46 (d, J=5.4 Hz, 1H), 7.05-7.43
(m, 6H), 7.47 (s, 1H), 7.55 (s, 1H), 7.94 (dd, J=2.4, 11.7 Hz, 1H),
8.50 (d, J=5.4 Hz, 1H), 8.92 (s, 1H), 12.45 (s, 1H)
[0616] ESI-MS: m/z=607 (M-1)
Example 279
1-{3-Fluoro-4-[6-methoxy-7-(2-morpholin-4-yl-ethoxy)-quinolin-4-yloxy]-phe-
nyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea
[0617] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.66-3.06 (m,
6H), 3.70-3.85 (m, 6H), 4.03 (s, 3H), 4.39 (t, J=5.8 Hz, 2H), 6.48
(d, J=5.4 Hz, 1H), 7.04-7.14 (m, 3H), 7.25-7.45 (m, 3H), 7.50 (s,
1H), 7.56 (s, 1H), 7.94 (dd, J=2.4, 11.7 Hz, 1H), 8.51 (d, J=5.4
Hz, 1H), 8.74 (s, 1H), 12.44 (s, 1H)
[0618] ESI-MS: m/z 607 (M-1)
Example 282
1-(3-Fluoro-4-{7-[2-(4-hydroxymethyl-piperidin-1-yl)-ethoxy]-6-methoxy-qui-
nolin-4-yloxy}-phenyl)-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea
[0619] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=20:1, 400 MHz): .delta.
1.58-1.99 (m, 5H), 2.43-2.62 (m, 2H), 3.16-3.40 (m, 4H), 3.50-3.54
(m, 2H), 3.73 (s, 2H), 4.03 (s, 3H), 4.45-4.51 (m, 2H), 6.47 (d,
J=5.4 Hz, 1H), 7.06-7.15 (m, 2H), 7.22-7.34 (m, 4H), 7.42 (s, 1H),
7.57 (s, 1H), 7.94 (dd, J=2.4, 11.7 Hz, 1H), 8.47 (d, J=5.4 Hz,
1H)
[0620] ESI-MS: m/z=637 (M+1), 635 (M-1)
Example 283
1-(3-Fluoro-4-{7-[2-(4-hydroxymethyl-piperidin-1-yl)-ethoxy]-6-methoxy-qui-
nolin-4-yloxy}-phenyl)-3-phenylacetyl-urea
[0621] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 1.13-1.76 (m,
7H), 2.11-2.26 (m, 2H), 2.87-3.11 (m, 4H), 3.37-3.48 (m, 2H), 3.70
(s, 2H), 3.95 (s, 3H), 4.26-4.33 (m, 2H), 6.32 (d, J=5.1 Hz, 1H),
7.07-7.50 (m, 7H), 7.35 (s, 1H), 7.48 (s, 1H), 7.57-7.65 (m, 1H),
8.13 (s, 1H), 8.40 (d, J=5.1 Hz, 1H), 10.59 (s, 1H)
[0622] Mass spectrometric value (ESI-MS, m/z): 603 (M.sup.++1)
Example 284
1-(3-Fluoro-4-{7-[2-(4-hydroxymethyl-piperidin-1-yl)-ethoxy]-6-methoxy-qui-
nolin-4-yloxy}-phenyl)-3-phenylacetyl-thiourea
[0623] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=10:1, 400 MHz): .delta.
1.45-1.88 (m, 5H), 2.37-2.50 (m, 2H), 3.08-3.18 (m, 2H), 3.26-3.34
(m, 2H), 3.50-3.54 (m, 2H), 3.76 (s, 2H), 4.02 (s, 3H), 4.41-4.47
(m, 2H), 6.47 (d, J=5.1 Hz, 1H), 7.22-7.47 (m, 7H), 7.56 (s, 1H),
7.94 (dd, J=2.4, 11.7 Hz, 1H), 8.48 (d, J=5.1 Hz, 1H)
[0624] ESI-MS: m/z=619 (M+1), 617 (M-1)
Example 286
1-{2-Fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(4-fluoro-phenyl)-acetyl]-urea
[0625] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.02-2.25 (m,
2H), 2.40-2.49 (m, 4H), 2.51 (t, J=7.1 Hz, 2H), 3.64-3.67 (m, 4H),
3.67 (s, 2H), 3.93 (s, 3H), 4.19 (t, J=6.7 Hz, 2H), 6.44 (d, J=5.4
Hz, 1H), 6.89-7.02 (m, 4H), 7.20-7.25 (m, 2H), 7.36 (s, 1H), 7.39
(s, 1H), 8.13 (t, J=8.5 Hz, 1H), 8.43 (d, J=5.4 Hz, 1H), 9.30 (s,
1H), 10.74 (s, 1H)
[0626] Mass spectrometric value (ESI-MS, m/z): 607 (M.sup.++1)
Example 288
1-{3-Fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea
[0627] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.12-2.19 (m,
2H), 2.50-2.66 (m, 6H), 3.72-3.81 (m, 6H), 4.03 (s, 3H), 4.28 (t,
J=6.6 Hz, 2H), 6.45 (d, J=5.4 Hz, 1H), 7.16-7.42 (m, 6H), 7.45 (s,
1H), 7.54 (s, 1H), 7.94 (dd, J=2.4, 11.5 Hz, 1H), 8.51 (d, J=5.4
Hz, 1H), 8.61 (s, 1H), 12.41 (s, 1H)
[0628] ESI-MS: m/z=623 (M+1), 621 (M-1)
Example 289
1-{3-Fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea
[0629] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.10-2.18 (m,
2H), 2.44-2.56 (m, 4H), 2.59 (t, J=7.2 Hz, 2H), 3.70-3.76 (m, 6H),
4.03 (s, 3H), 4.28 (t, J=6.6 Hz, 2H), 6.45 (d, J=5.4 Hz, 1H),
7.01-7.13 (m, 3H), 7.26-7.44 (m, 3H), 7.44 (s, 1H), 7.54 (s, 1H),
7.93 (dd, J=2.4, 11.5 Hz, 1H), 8.50 (d, J=5.4 Hz, 1H), 8.55 (s,
1H), 12.41 (s, 1H)
[0630] ESI-MS: m/z=623 (M+1), 621 (M-1)
Example 291
1-{4-[7-(3-Diethylamino-propoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phen-
yl}-3-phenylacetyl-urea
[0631] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 1.31 (t, J=7.3
Hz, 6H), 2.29-2.39 (m, 2H), 2.93-3.02 (m, 4H), 3.06-3.17 (m, 2H),
3.80 (s, 2H), 4.01 (s, 3H), 4.26 (t, J=6.0 Hz, 2H), 6.38 (d, J=5.1
Hz, 1H), 7.18-7.44 (m, 8H), 7.56 (s, 1H), 7.68 (dd, J=2.4, 12.2 Hz,
1H), 8.46 (d, J=5.1 Hz, 1H), 8.85 (br, 1H), 10.72 (s, 1H)
[0632] ESI-MS: m/z=575 (M+1)
Example 292
1-{3-Fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-phenylacetyl-urea
[0633] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 1.94-2.05 (m,
4H), 2.30-2.40 (m, 2H), 2.80-3.15 (m, 6H), 3.78 (s, 2H), 4.02 (s,
3H), 4.27 (t, J=6.1 Hz, 2H), 6.38 (d, J=1.0, 5.4 Hz, 1H), 7.16-7.44
(m, 8H), 7.56 (s, 1H), 7.68 (dd, J=2.4, 12.7 Hz, 1H), 8.45 (br,
1H), 8.47 (d, J=5.4 Hz, 1H), 10.69 (s, 1H)
Example 293
1-{4-[7-(3-Diethylamino-propoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phen-
yl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea
[0634] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 1.27 (t, J=7.2
Hz, 6H), 2.25-2.35 (m, 2H), 2.87-3.10 (m, 6H), 3.84 (s, 2H), 4.01
(s, 3H), 4.26 (t, J=6.1 Hz, 2H), 6.38 (d, J=5.4 Hz, 1H), 7.10-7.25
(m, 4H), 7.29-7.40 (m, 2H), 7.41 (s, 1H), 7.56 (s, 1H), 7.67 (dd,
J=2.2, 12.7 Hz, 1H), 8.47 (d, J=5.4 Hz, 1H), 8.91 (br, 1H), 10.67
(s, 1H)
[0635] ESI-MS: m/z=593 (M+1)
Example 294
1-{3-Fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-yl-propoxy)-quinolin-4-yloxy]-p-
henyl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea
[0636] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 1.93-2.00 (m,
4H), 2.28-2.36 (m, 2H), 2.75-3.09 (m, 6H), 3.83 (s, 2H), 4.02 (s,
3H), 4.27 (t, J=6.3 Hz, 2H), 6.38 (dd, J=1.0, 5.1 Hz, 1H),
7.10-7.28 (m, 4H), 7.30-7.39 (m, 2H), 7.41 (s, 1H), 7.55 (s, 1H),
7.68 (dd, J=2.2, 11.7 Hz, 1H), 8.46 (d, J=5.1 Hz, 1H), 8.85 (br,
1H), 10.66 (s, 1H)
[0637] ESI-MS: m/z=593 (M+1)
Example 295
1-{3-Fluoro-4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea
[0638] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 1.45-1.55 (m,
2H), 1.68-1.79 (m, 4H), 2.09-2.16 (m, 2H), 2.54-2.82 (m, 6H), 3.83
(s, 2H), 4.02 (s, 3H), 4.25 (t, J=6.6 Hz, 2H), 6.38 (dd, J=0.7, 5.4
Hz, 1H), 7.10-7.31 (m, 4H), 7.30-7.39 (m, 2H), 7.41 (s, 1H), 7.55
(s, 1H), 7.68 (dd, J=2.2, 12.7 Hz, 1H), 8.46 (d, J=5.4 Hz, 1H),
9.00 (br, 1H), 10.68 (s, 1H)
[0639] ESI-MS: m/z=605 (M+1)
Example 296
1-(3-Fluoro-4-{6-methoxy-7-[3-(4-methyl-piperazin-1-yl)-propoxy]-quinolin--
4-yloxy}-phenyl)-3-[2-(2-fluoro-phenyl)-acetyl]-urea
[0640] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.08-2.17 (m,
2H), 2.28-2.70 (m, 13H), 3.81 (s, 2H), 4.03 (s, 3H), 4.23-4.39 (m,
2H), 6.39 (d, J=5.4 Hz, 1H), 7.12-7.23 (m, 4H), 7.17-7.40 (m, 2H),
7.43 (s, 1H), 7.55 (s, 1H), 7.69 (dd, J=2.2, 12.1 Hz, 1H), 8.47 (d,
J=5.4 Hz, 1H), 8.70 (br, 1H), 10.65 (s, 1H)
Example 297
1-(3-Fluoro-4-{6-methoxy-7-[3-(4-methyl-piperazin-1-yl)-propoxy]-quinolin--
4-yloxy}-phenyl)-3-(2-m-toluoyl-acetyl)-thiourea
[0641] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.08-2.17 (m,
2H), 2.32-2.44 (m, 5H), 2.52-2.65 (m, 8H), 3.71 (s, 2H), 4.02 (s,
3H), 4.26 (t, J=6.3 Hz, 2H), 6.44 (d, J=5.4 Hz, 1H), 7.01-7.55 (m,
8H), 7.93 (dd, J=2.7, 11.5 Hz, 1H), 8.48-8.54 (m, 2H), 12.49 (s,
1H)
[0642] ESI-MS: m/z=632 (M+1)
Example 298
1-{3-Chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea
[0643] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.15-2.22 (m,
2H), 2.52-2.58 (m, 4H), 2.63 (t, J=7.1 Hz, 2H), 3.76 (t, J=4.6 Hz,
4H), 3.80 (s, 2H), 4.03 (s, 3H), 4.28 (t, J=6.6 Hz, 2H), 6.38 (d,
J=5.1 Hz, 1H), 7.13-7.25 (m, 3H), 7.29-7.42 (m, 2H), 7.46 (s, 1H),
7.55 (s, 1H), 7.62 (dd, J=2.4, 8.8 Hz, 1H), 8.00 (d, J=2.4 Hz, 1H),
8.50 (d, J=5.1 Hz, 1H) 8.97 (s, 1H), 12.39 (s, 1H)
[0644] ESI-MS: m/z=639 (M+1)
Example 299
1-{3-Chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea
[0645] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.15-2.26 (m,
2H), 2.55-2.75 (m, 6H), 3.77 (s, 2H), 3.78-3.83 (m, 4H), 4.03 (s,
3H), 4.29 (t, J=6.6 Hz, 2H), 6.39 (d, J=5.1 Hz, 1H), 7.02-7.13 (m,
4H), 7.36-7.44 (m, 1H), 7.48 (s, 1H), 7.55 (s, 1H), 7.62 (dd,
J=2.4, 8.8 Hz, 1H), 8.00 (d, J=2.4 Hz, 1H), 8.50 (d, J=5.1 Hz, 1H),
8.85 (s, 1H), 12.39 (s, 1H)
[0646] ESI-MS: m/z=639 (M+1)
Example 300
1-{3-Chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-phenylacetyl-thiourea
[0647] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.14-2.24 (m,
2H), 2.53-2.72 (m, 6H), 3.76-3.80 (m, 6H), 4.03 (s, 3H), 4.28 (t,
J=6.6 Hz, 2H), 6.38 (d, J=5.4 Hz, 1H), 7.22-7.45 (m, 7H), 7.55 (s,
1H), 7.62 (dd, J=2.4, 8.8 Hz, 1H), 8.00 (d, J=2.4 Hz, 1H), 8.50 (d,
J=5.4 Hz, 1H), 8.72 (s, 1H), 12.44 (s, 1H)
[0648] ESI-MS: m/z=621 (M+1)
Example 301
1-{3-Chloro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-(2-o-toluoyl-acetyl)-thiourea
[0649] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=30:1, 400 MHz): .delta.
2.20-2.32 (m, 2H), 2.36 (s, 3H), 2.72-2.90 (m, 6H), 3.78 (s, 2H),
3.80-3.85 (m, 4H), 4.04 (s, 3H), 4.36 (t, J=6.1 Hz, 2H), 6.41 (d,
J=5.4 Hz, 1H), 7.21-7.33 (m, 5H), 7.54-7.61 (m, 2H), 7.65 (dd,
J=2.4, 8.6 Hz, 1H), 8.04 (d, J=2.4 Hz, 1H), 8.45 (br, 1H), 9.00
(br, 1H), 12.50 (br, 1H)
[0650] ESI-MS: m/z=635 (M+1)
Example 302
1-{3-Fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-(2-o-toluoyl-acetyl)-thiourea
[0651] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.20-2.33 (m,
2H), 2.36 (s, 3H), 2.50-2.59 (m, 6H), 3.79 (s, 2H), 3.81-3.90 (m,
4H), 4.03 (s, 3H), 4.29 (t, J=6.3 Hz, 2H), 6.47 (d, J=5.4 Hz, 1H),
7.22-7.34 (m, 5H), 7.42 (d, J=8.1 Hz, 1H), 7.49 (s, 1H), 7.55 (s,
1H), 7.96 (dd, J=2.4, 11.7 Hz, 1H), 8.44 (br, 1H), 8.50 (d, J=5.4
Hz, 1H), 12.52 (s, 1H)
[0652] ESI-MS: m/z=619 (M+1)
Example 303
1-{3-Fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-(2-m-toluoyl-acetyl)-thiourea
[0653] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.10-2.20 (m,
2H), 2.39 (s, 3H), 2.55-2.67 (m, 6H), 3.71 (s, 2H), 3.75-3.80 (m,
4H), 4.03 (s, 3H), 4.28 (t, J=6.6 Hz, 2H), 6.46 (d, J=4.6 Hz, 1H),
7.08-7.36 (m, 5H), 7.41 (d, J=8.8 Hz, 1H), 7.44 (s, 1H), 7.55 (s,
1H), 7.91-8.01 (m, 1H), 8.48-8.54 (m, 1H), 8.96 (br, 1H), 12.53 (s,
1H)
[0654] ESI-MS: m/z=619 (M+1)
Example 304
1-{3-Fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-ph-
enyl}-3-(2-p-toluoyl-acetyl)-thiourea
[0655] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.14-2.24 (m,
2H), 2.38 (s, 3H), 2.55-2.72 (m, 6H), 3.72 (s, 2H), 3.76-3.82 (m,
4H), 4.03 (s, 3H), 4.28 (t, J=6.4 Hz, 2H), 6.46 (d, J=5.4 Hz, 1H),
7.16-7.28 (m, 5H), 7.40 (d, J=8.8 Hz, 1H), 7.46 (s, 1H), 7.54 (s,
1H), 7.93 (dd, J=2.4, 11.5 Hz, 1H), 8.50 (d, J=5.4 Hz, 1H), 8.64
(s, 1H), 12.52 (s, 1H)
[0656] ESI-MS: m/z=619 (M+1)
Example 305
1-{3-Fluoro-4-[7-(3-imidazol-1-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phe-
nyl}-3-phenylacetyl-urea
[0657] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 2.19-2.38 (m,
2H), 3.74 (s, 2H), 3.97 (s, 3H), 4.09 (t, J=6.3 Hz, 2H), 4.19 (t,
J=6.8 Hz, 2H), 6.44 (d, J=5.4 Hz, 1H), 6.89 (s, 1H), 7.15-7.50 (m,
9H), 7.54 (s, 1H), 7.64 (s, 1H), 7.76-7.88 (m, 1H), 8.47 (d, J=5.4
Hz, 1H), 10.64 (s, 1H), 11.05 (s, 1H)
[0658] Mass spectrometric value (ESI-MS, m/z): 570 (M+1).sup.+
Example 306
1-{3-Fluoro-4-[7-(3-imidazol-1-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phe-
nyl}-3-[2-(2-fluoro-phenyl)-acetyl]-urea
[0659] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 2.20-2.40 (m,
2H), 3.85 (s, 2H), 3.97 (s, 3H), 4.05-4.15 (m, 2H), 4.15-4.26 (m,
2H), 6.45 (d, J=5.1 Hz, 1H), 6.90 (s, 1H), 7.08-7.50 (m, 8H), 7.54
(s, 1H), 7.64 (s, 1H), 7.77-7.90 (m, 1H), 8.47 (d, J=5.1 Hz, 1H),
10.57 (s, 1H), 11.08 (s, 1H)
[0660] Mass spectrometric value (ESI-MS, m/z): 588 (M+1).sup.+
Example 307
1-{3-Fluoro-4-[7-(3-imidazol-1-yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phe-
nyl}-3-phenylacetyl-thiourea
[0661] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 2.21-2.39 (m,
2H), 3.83 (s, 2H), 3.97 (s, 3H), 4.00-4.20 (m, 2H), 4.15-4.30 (m,
2H), 6.50 (d, J=5.3 Hz, 1H), 6.91 (s, 1H), 7.17-7.60 (m, 10H), 7.70
(s, 1H), 7.95-8.07 (m, 1H), 8.49 (d, J=5.3 Hz, 1H), 11.80 (s, 1H),
12.51 (s, 1H)
[0662] Mass spectrometric value (ESI-MS, m/z): 586 (M+1).sup.+
Example 308
1-(3-Fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-methoxy-qu-
inolin-4-yloxy}-phenyl)-3-phenylacetyl-urea
[0663] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 1.22-2.43 (m,
9H), 2.50-2.65 (m, 2H), 2.98-3.12 (m, 2H), 3.39-3.49 (m, 2H), 3.70
(s, 2H), 3.95 (s, 3H), 4.13-4.26 (m, 2H), 6.31 (d, J=5.4 Hz, 1H),
7.04-7.41 (m, 7H), 7.35 (s, 1H), 7.48 (s, 1H), 7.57-7.63 (m, 1H),
8.21 (s, 1H), 8.40 (d, J=5.4 Hz, 1H), 10.69 (s, 1H)
[0664] Mass spectrometric value (ESI-MS, m/z): 617 (M.sup.++1)
Example 309
1-(3-Fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-methoxy-qu-
inolin-4-yloxy}-phenyl)-3-phenylacetyl-thiourea
[0665] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=10:1, 400 MHz): .delta.
1.75-3.00 (m, 9H), 3.30-3.72 (m, 6H), 3.76 (s, 2H), 4.04 (s, 3H),
4.34 (t, J=5.4 Hz, 2H), 6.50 (d, J=5.4 Hz, 1H), 7.24-7.46 (m, 8H),
7.58 (s, 1H), 7.96 (dd, J=2.4, 11.7 Hz, 1H), 8.47 (d, J=54 Hz,
1H)
[0666] ESI-MS: m/z=633 (M+1)
Example 310
1-(3-Fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-methoxy-qu-
inolin-4-yloxy}-phenyl)-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea
[0667] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=20:1, 400 MHz): .delta.
1.00-3.20 (m, 15H), 3.73 (s, 2H), 4.02 (s, 3H), 4.27 (t, J=6.1 Hz,
2H), 6.45 (d, J=5.4 Hz, 1H), 7.08-7.17 (m, 2H), 2.22-7.44 (m, 5H),
7.54 (s, 1H), 7.94 (dd, J=2.4, 11.5 Hz, 1H), 8.49 (d, J=5.4 Hz,
1H)
[0668] ESI-MS: m/z=651 (M+1)
Example 311
1-(2-Fluoro-4-{7-[3-(4-hydroxymethyl-piperidin-1-yl)-propoxy]-6-methoxy-qu-
inolin-4-yloxy}-phenyl)-3-phenyl-acetyl-urea
[0669] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 1.22-2.19 (m,
9H), 2.49-2.69 (m, 2H), 2.87-3.07 (m, 2H), 3.41-3.50 (m, 2H), 3.70
(s, 2H), 3.93 (s, 3H), 4.17-4.21 (m, 2H), 6.43 (d, J=5.3 Hz, 1H),
6.89-6.94 (m, 2H), 7.19-7.45 (m, 5H), 7.36 (s, 1H), 7.40 (s, 1H),
7.65 (s, 1H), 8.13 (t, J=8.8 Hz, 1H), 8.43 (d, J=5.3 Hz, 1H), 10.66
(s, 1H)
[0670] Mass spectrometric value (ESI-MS, m/z): 617 (M.sup.++1)
Example 312
1-{3-Fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-phenylacetyl-thiourea
[0671] .sup.1H-NMR (DMSO-d.sub.6, 400 MHz): .delta. 3.17-3.40 (m,
6H), 3.50-3.65 (m, 4H), 3.83 (s, 2H), 3.94 (s, 3H), 4.00-4.13 (m,
2H), 4.13-4.26 (m, 1H), 4.90-5.00 (m, 1H), 6.48 (d, J=5.1 Hz, 1H),
7.17-7.57 (m, 9H), 7.93-8.10 (m, 1H), 8.49 (d, J=5.1 Hz, 1H), 11.81
(s, 1H), 12.50 (s, 1H)
[0672] Mass spectrometric value (ESI-MS, m/z): 621 (M+1).sup.+
Example 314
1-[2-(2-Chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4-y-
l-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea
[0673] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.48-2.54 (m,
2H), 2.57-2.73 (m, 4H), 3.70-3.79 (m, 4H), 3.90 (s, 2H), 4.02 (s,
3H), 4.15-4.32 (m, 3H), 6.45 (d, J=5.4 Hz, 1H), 7.32-7.43 (m, 5H),
7.45 (s, 1H), 7.47-7.52 (m, 1H), 7.54 (s, 1H), 7.95 (dd, J=2.6,
11.6 Hz, 1H), 8.50 (d, J=5.4 Hz, 1H), 8.69 (s, 1H), 12.43 (s,
1H)
[0674] ESI-MS: m/z=655 (M+1)
Example 315
1-{3-Fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea
[0675] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.49-2.56 (m,
2H), 2.61-2.66 (m, 2H), 2.67-2.74 (m, 2H), 3.72-3.81 (m, 6H), 4.02
(s, 3H), 4.16-4.24 (m, 2H), 4.26-4.33 (m, 1H), 6.45 (d, J=5.4 Hz,
1H), 7.14-7.42 (m, 6H), 7.46 (s, 1H), 7.54 (s, 1H), 7.94 (dd,
J=2.4, 11.5 Hz, 1H), 8.50 (d, J=5.4 Hz, 1H), 8.73 (s, 1H), 12.42
(s, 1H)
[0676] ESI-MS: m/z=639 (M+1)
Example 316
1-[2-(2-Chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1-y-
l-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea
[0677] .sup.1H-NMR (DMSO, 400 MHz): .delta. 1.40-1.52 (m, 2H),
1.55-1.70 (m, 4H), 2.62-2.93 (m, 6H), 3.63 (s, 2H), 3.96 (s, 3H),
3.98-4.22 (m, 3H), 6.50 (d, J=5.1 Hz, 1H), 7.27-7.51 (m, 6H), 7.54
(s, 1H), 7.82 (dd, J=2.2, 11.9 Hz, 1H), 8.49 (d, J=5.1 Hz, 1H),
9.95 (s, 1H), 11.91 (br, 1H), 12.45 (br, 1H)
[0678] ESI-MS: m/z=653 (M+1)
Example 317
1-[2-(2-Chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea
[0679] .sup.1H-NMR (DMSO, 400 MHz): .delta. 1.84-1.92 (m, 4H),
3.01-3.36 (m, 6H), 3.63 (s, 2H), 3.97 (s, 3H), 4.10-4.26 (m, 3H),
6.51 (d, J=5.1 Hz, 1H), 7.27-7.51 (m, 6H), 7.55 (s, 1H), 7.84 (dd,
J=2.4, 12.2 Hz, 1H), 8.51 (d, J=5.1 Hz, 1H), 9.96 (s, 1H), 11.91
(br, 1H), 12.45 (br, 1H)
[0680] ESI-MS: m/z=639 (M+1)
Example 318
1-{3-Fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea
[0681] .sup.1H-NMR (DMSO, 400 MHz): .delta. 1.32-1.60 (m, 6H),
2.50-2.68 (m, 6H), 3.63 (s, 2H), 3.95 (s, 3H), 4.04-4.20 (m, 3H),
6.49 (d, J=5.1 Hz, 1H), 7.12-7.24 (m, 2H), 2.26-7.57 (m, 6H), 8.02
(dd, J=2.2, 12.2 Hz, 1H), 8.50 (d, J=5.1 Hz, 1H), 11.87 (br, 1H),
12.42 (br, 1H)
[0682] ESI-MS: m/z=637 (M+1)
Example 319
1-{3-Fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea
[0683] .sup.1H-NMR (DMSO, 400 MHz): .delta. 1.78-1.85 (m, 4H),
2.80-3.15 (m, 4H), 3.32-3.35 (m, 2H), 3.63 (s, 2H), 3.96 (s, 3H),
4.08-4.20 (m, 3H), 6.50 (d, J=5.4 Hz, 1H), 7.13-7.46 (m, 6H), 7.54
(s, 1H), 7.83 (dd, J=2.7, 12.9 Hz, 1H), 8.49 (d, J=5.4 Hz, 1H),
9.93 (s, 1H), 11.88 (br, 1H), 12.43 (br, 1H)
[0684] ESI-MS: m/z=623 (M+1)
Example 320
1-[2-(3-Chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4-y-
l-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea
[0685] .sup.1H-NMR (DMSO, 400 MHz): .delta. 3.34-3, 43 (m, 6H),
3.59-3.64 (m, 4H), 3.87 (s, 2H), 3.95 (s, 3H), 4.06-4.14 (m, 2H),
4.19 (d, J=6.6 Hz, 1H), 6.49 (d, J=5.4 Hz, 1H), 7.26-7.57 (m, 8H),
8.01 (dd, J=2.6, 12.4 Hz, 1H), 8.50 (d, J=5.4 Hz, 1H), 11.83 (s,
1H), 12.43 (s, 1H)
[0686] ESI-MS: m/z=655 (M+1)
Example 321
1-[2-(3-Chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1-y-
l-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea
[0687] .sup.1H-NMR (DMSO, 400 MHz): .delta. 1.37-1.61 (m, 6H),
2.50-2.55 (m, 6H), 3.62 (s, 2H), 3.95 (s, 3H), 4.05-4.21 (m, 3H),
6.49 (d, J=5.1 Hz, 1H), 7.21-7.55 (m, 7H), 7.32 (dd, J=2.4, 12.4
Hz, 1H), 8.49 (d, J=5.1 Hz, 1H), 9.93 (s, 1H), 11.79 (br, 1H),
12.42 (br, 1H)
[0688] ESI-MS: m/z=655 (M+1)
Example 322
1-[2-(3-Chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea
[0689] .sup.1H-NMR (DMSO, 400 MHz): .delta. 1.82-1.90 (m, 4H),
2.90-3.50 (m, 6H), 3.62 (s, 2H), 3.97 (s, 3H), 4.09-4.25 (m, 3H),
6.51 (d, J=5.1 Hz, 1H), 7.22-7.57 (m, 7H), 7.82 (dd, J=2.2, 12.0
Hz, 1H), 8.50 (d, J=5.1 Hz, 1H), 9.94 (s, 1H), 11.83 (br, 1H),
12.44 (br, 1H)
Example 323
1-{3-Fluoro-4-[7-(2-hydroxy-3-morpholin-4-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea
[0690] .sup.1H-NMR (DMSO, 400 MHz): .delta. 3.33-3.41 (m, 6H),
3.57-3.63 (m, 4H), 3.87 (s, 2H), 3.95 (s, 3H), 4.04-4.22 (m, 3H),
6.48 (d, J=5.4 Hz, 1H), 7.05-7.23 (m, 3H), 7.36-7.56 (m, 5H), 8.01
(dd, J=2.1, 12.3 Hz, 1H), 8.50 (d, J=5.4 Hz, 1H), 11.83 (s, 1H),
12.45 (s, 1H)
[0691] ESI-MS: m/z=639 (M+1)
Example 324
1-{3-Fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea
[0692] .sup.1H-NMR (DMSO, 400 MHz): .delta. 1.38-1.48 (m, 2H),
1.52-1.64 (m, 4H), 2.51-2.79 (m, 6H), 3.61 (s, 2H), 3.95 (s, 3H),
4.06-4.21 (m, 3H), 6.49 (d, J=5.1 Hz, 1H), 7.06-7.56 (m, 7H), 8.02
(dd, J=2.4, 12.4 Hz, 1H), 8.50 (d, J=5.1 Hz, 1H), 9.96 (s, 1H),
11.83 (br, 1H), 12.45 (br, 1H)
[0693] ESI-MS: m/z=637 (M+1)
Example 325
1-{3-Fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(3-fluoro-phenyl)-acetyl]-thiourea
[0694] .sup.1H-NMR (DMSO, 400 MHz): .delta. 1.84-1.92 (m, 4H),
3.00-3.40 (m, 6H), 3.88 (s, 2H), 3.96 (s, 3H), 4.10-4.25 (m, 3H),
6.50 (d, J=5.1 Hz, 1H), 7.06-7.58 (m, 7H), 8.01 (dd, J=2.4, 12.2
Hz, 1H), 8.51 (d, J=5.1 Hz, 1H), 9.97 (s, 1H), 11.83 (br, 1H),
12.45 (br, 1H)
[0695] ESI-MS: m/z=623 (M+1)
Example 326
1-[2-(4-Chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-morpholin-4-y-
l-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea
[0696] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=20:1, 400 MHz): .delta.
2.53-2.73 (m, 6H), 3.72 (s, 2H), 3.73-3.78 (m, 4H), 4.03 (s, 3H),
4.14-4.34 (m, 3H), 6.47 (d, J=5.4 Hz, 1H), 7.20-7.34 (m, 4H),
7.37-7.42 (m, 2H), 7.44 (s, 1H), 7.56 (s, 1H), 7.94 (dd, J=2.6,
11.6 Hz, 1H), 8.48 (d, J=5.4 Hz, 1H)
[0697] ESI-MS: m/z=655 (M+1)
Example 327
1-[2-(4-Chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-piperidin-1-y-
l-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea
[0698] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=20:1, 400 MHz): .delta.
1.39-1.43 (m, 2H), 1.57-1.66 (m, 4H), 2.55-2.72 (m, 6H), 3.61 (s,
2H), 3.95 (s, 3H), 4.06-4.09 (m, 2H), 4.24-4.31 (m, 1H), 6.39 (d,
J=5.4 Hz, 1H), 7.10-7.30 (m, 7H), 7.43-7.49 (m, 1H), 7.48 (s, 1H),
8.34 (d, J=5.4 Hz, 1H)
[0699] ESI-MS: m/z=653 (M+1)
Example 328
1-[2-(4-Chloro-phenyl)-acetyl]-3-{3-fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1--
yl-propoxy)-6-methoxy-quinolin-4-yloxy]-phenyl}-thiourea
[0700] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=20:1, 400 MHz): .delta.
2.01-2.08 (m, 4H), 3.3.30-3.35 (m, 6H), 3.65 (s, 2H), 3.95 (s, 3H),
4.06-4.20 (m, 2H), 4.35-4.45 (m, 1H), 6.41 (d, J=5.4 Hz, 1H),
7.12-7.32 (m, 7H), 7.49 (s, 1H), 7.88 (dd, J=2.4, 11.7 Hz, 1H),
8.37 (d, J=5.4 Hz, 1H)
[0701] ESI-MS: m/z=639 (M+1)
Example 329
1-{3-Fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea
[0702] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=20:1, 400 MHz): .delta.
1.43-1.55 (m, 2H), 1.62-1.78 (m, 4H), 2.48-2.90 (m, 6H), 3.63 (s,
2H), 3.95 (s, 3H), 4.05-4.18 (m, 2H), 4.32-4.43 (m, 1H), 6.38 (d,
J=5.4 Hz, 1H), 6.83-7.03 (m, 1H), 7.15-7.30 (m, 6H), 7.32 (s, 1H),
8.48 (s, 1H), 8.37 (d, J=5.4 Hz, 1H)
[0703] ESI-MS: m/z=637 (M+1)
Example 330
1-{3-Fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-thiourea
[0704] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=20:1, 400 MHz): .delta.
2.09-2.15 (m, 4H), 3.33-3.43 (m, 6H), 3.70 (s, 2H), 4.04 (s, 3H),
4.14-4.27 (m, 2H), 4.46-4.53 (m, 1H), 6.49 (d, J=5.4 Hz, 1H),
6.96-7.13 (m, 2H), 7.22-7.40 (m, 5H), 7.58 (s, 1H), 7.96 (dd,
J=2.4, 11.5 Hz, 1H), 8.44 (d, J=5.4 Hz, 1H)
[0705] ESI-MS: m/z=623 (M+1)
Example 331
1-{3-Fluoro-4-[7-(2-hydroxy-3-piperidin-1-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-(2-phenylacetyl)-thiourea
[0706] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=20:1, 400 MHz): .delta.
1.50-1.60 (m, 2H), 1.76-1.84 (m, 4H), 2.93-3.07 (m, 6H), 3.70 (s,
2H), 3.97 (s, 3H), 4.08-4.19 (m, 2H), 4.43-4.51 (m, 1H), 6.42 (d,
J=5.4 Hz, 1H), 7.18-7.40 (m, 8H), 7.51 (s, 1H), 7.90 (dd, J=2.3,
11.6 Hz, 1H) 8.40 (d, J=5.4 Hz, 1H)
[0707] ESI-MS: m/z=619 (M+1)
Example 332
1-{3-Fluoro-4-[7-(2-hydroxy-3-pyrrolidin-1-yl-propoxy)-6-methoxy-quinolin--
4-yloxy]-phenyl}-3-(2-phenyl-acetyl)-thiourea
[0708] .sup.1H-NMR (CDCl.sub.3:CD.sub.3OD=20:1, 400 MHz): .delta.
2.03-2.11 (m, 4H), 3.20-3.40 (m, 6H), 3.70 (s, 2H), 3.98 (s, 3H),
4.09-4.22 (m, 2H), 4.43-4.51 (m, 1H), 6.43 (d, J=5.0 Hz, 1H),
7.19-7.40 (m, 8H), 7.52 (s, 1H), 7.90 (dd, J=2.6, 11.7 Hz, 1H),
8.41 (d, J=5.0 Hz, 1H)
[0709] ESI-MS: m/z=605 (M+1)
Example 333
1-{3-Fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-(2-o-toluoyl-acetyl)-thiourea
[0710] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.36 (s, 3H),
2.70-2.90 (m, 6H), 3.77-3.87 (m, 6H), 4.02 (s, 3H), 4.20-4.24 (m,
2H), 4.40-4.47 (m, 1H), 6.49 (d, J=5.4 Hz, 1H), 7.16-7.32 (m, 5H),
7.42 (d, J=9.0 Hz, 1H), 7.55 (s, 1H), 7.62 (s, 1H), 7.97 (dd,
J=2.4, 11.7 Hz, 1H), 8.50 (d, J=5.4 Hz, 1H), 8.55 (s, 1H), 12.54
(s, 1H)
[0711] ESI-MS: m/z=635 (M+1)
Example 334
1-{3-Fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-(2-m-toluoyl-acetyl)-thiourea
[0712] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.39 (s, 3H),
2.60-2.85 (m, 6H), 3.72 (s, 2H), 3.77-3.83 (m, 4H), 4.02 (s, 3H),
4.22 (d, J=5.1 Hz, 2H), 4.34-4.42 (m, 1H), 6.49 (d, J=5.4 Hz, 1H),
7.09-7.35 (m, 5H), 7.41 (d, J=9.0 Hz, 1H), 7.54 (s, 1H), 7.55 (s,
1H), 7.95 (dd, J=2.6, 11.6 Hz, 1H), 8.51 (d, J=5.4 Hz, 1H), 8.57
(s, 1H), 12.52 (s, 1H)
[0713] ESI-MS: m/z=635 (M+1)
Example 335
1-{3-Fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-(2-p-toluoyl-acetyl)-thiourea
[0714] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.37 (s, 3H),
2.55-2.79 (m, 6H), 3.70-3.80 (m, 6H), 4.01 (s, 3H), 4.19-4.23 (m,
2H), 4.31-4.38 (m, 1H), 6.46 (d, J=5.4 Hz, 1H), 7.10-7.28 (m, 5H),
7.40 (d, J=9.0 Hz, 1H), 7.51 (s, 1H), 7.56 (s, 1H), 7.93 (dd,
J=2.4, 11.7 Hz, 1H), 8.51 (d, J=5.4 Hz, 1H), 8.84 (s, 1H), 12.54
(s, 1H)
[0715] ESI-MS: m/z=635 (M+1)
Example 336
1-{3-Fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-[2-(4-fluoro-phenyl)-acetyl]-urea
[0716] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.43-2.65 (m,
6H), 3.62-3.72 (m, 4H), 3.67 (s, 2H), 3.94 (s, 3H), 4.09-4.25 (m,
3H), 6.33 (d, J=5.4 Hz, 1H), 6.91-7.24 (m, 6H), 7.38 (s, 1H), 7.48
(s, 1H), 7.60-7.64 (m, 1H), 8.41 (d, J=5.4 Hz, 1H), 8.88 (s, 1H),
10.62 (s, 1H)
[0717] Mass spectrometric value (ESI-MS, m/z): 623 (M.sup.++1)
Example 337
1-{3-Fluoro-4-[7-(2-hydroxy-3-morpholin-1-yl-propoxy)-6-methoxy-quinolin-4-
-yloxy]-phenyl}-3-(2-phenyl-acetyl)-urea
[0718] .sup.1H-NMR (CDCl.sub.3, 400 MHz): .delta. 2.44-2.65 (m,
6H), 3.68-3.76 (m, 4H), 3.69 (s, 2H), 3.94 (s, 3H), 4.08-4.23 (m,
3H), 6.32 (d, J=5.1 Hz, 1H), 7.11-7.35 (m, 7H), 7.39 (s, 1H), 7.49
(s, 1H), 7.60-7.63 (m, 1H), 8.41 (m, d, J=5.1 Hz, 1H), 8.60 (s,
1H), 10.64 (s, 1H)
[0719] Mass spectrometric value (ESI-MS, m/z): 605 (M.sup.++1)
Pharmacological Test Example 1
Measurement (1) of Inhibitory Activity Against
Met-Autophosphorylation Using ELISA Method
[0720] Human epidermal cancer cells A431 were cultured in an RPMI
1640 medium containing 10% fetal calf serum (purchased from GIBCO
BRL) within a 5% carbon dioxide incubator until 50 to 90%
confluent. Cells were cultured with RPMI medium containing 0.1%
fetal calf serum in 96-well flat-bottom plate in an amount of
3.times.10.sup.4 per well, and were incubated at 37.degree. C.
overnight. The medium was then replaced by a fresh RPMI medium
containing 0.1% fetal calf serum. A solution of the test compound
in dimethyl sulfoxide was added to each well, and the cells were
incubated at 37.degree. C. for additional one hr. A human
recombinant hepatocyte growth factor (hereinafter abbreviated to
"HGF") was added to a final concentration of 50 ng/ml, and the
stimulation of cells was carried out at 37.degree. C. for 5 min.
The medium was removed, the cells were washed with phosphate
buffered saline (pH 7.4), and 50 .mu.l of lysis buffer (20 mM HEPES
(pH 7.4), 150 mM NaCl, 0.2% Triton X-100, 10% glycerol, 5 mM sodium
orthovanadylate, 5 mM disodium ethylenediaminetetraacetate, and 2
mM Na.sub.4P.sub.2O.sub.7) was then added thereto. The mixture was
shaken at 4.degree. C. for 2 hr to prepare a cell extract.
[0721] Separately, phosphate buffered saline (50 .mu.l, pH 7.4)
containing 5 .mu.g/ml of anti-phospho-tyrosine antibody (PY20;
purchased from Transduction Laboratories) was added to a microplate
for ELISA (Maxisorp; purchased from NUNC), followed by gentle
agitation at 4.degree. C. overnight to coat the surface of the
wells with the antibody. After washing of the plate, 300 .mu.l of a
blocking solution was added, followed by gentle agitation at room
temperature for 2 hr to perform blocking. After washing, the whole
quantity of the cell extract was transferred to the wells, and the
plate was then allowed to incubate at 4.degree. C. overnight. After
washing, an anti-HGF receptor antibody (h-Met (C-12), purchased
from Santa Cruz Biotechnology) was allowed to react at room
temperature for one hr, and, after washing, a peroxidase-labeled
anti-rabbit Ig antibody (purchased from Amersham) was allowed to
react at room temperature for one hr. After washing, a chromophoric
substrate for peroxidase (purchased from Sumitomo Bakelite Co.,
Ltd.) was added thereto to initiate a reaction. After a suitable
level of color development, a reaction termination solution was
added to stop the reaction, and the absorbance at 450 nm was
measured with a microplate reader. The met-phosphorylation
inhibitory activity for each well was determined by presuming the
absorbance with the addition of HGF and the vehicle to compounds to
be 0% met-phosphorylation inhibitory activity and the absorbance
with the addition of the vehicle to compounds and without HGF to be
100% met phosphorylation inhibitory activity. The concentration of
the test compound was varied on several levels, the inhibition (%)
of met-phosphorylation was determined for each case, and the
concentration of the test compound necessary for inhibiting 50% of
met phosphorylation (IC.sub.50) was calculated. The results are
shown in Table 1.
TABLE-US-00003 TABLE 1 Example No. IC.sub.50, .mu.M 1 0.0087 2
0.0118 3 0.0197 11 0.0581
Pharmacological Test Example 2
Measurement (2) of Inhibitory Activity Against
Met-Autophosphorylation Using ELISA Method
[0722] Human gastric cancer cells MKN45 were maintained in RPMI
1640 medium containing 10% fetal calf serum (purchased from GIBCO
BRL) in 5% carbon dioxide incubator until 50 to 90% confluent.
Cells were cultured with RPMI medium containing 0.1% fetal calf
serum in 96-well flat-bottom plate in an amount of 3.times.10.sup.4
per well, and were incubated at 37.degree. C. overnight. The medium
was then replaced by a fresh RPMI medium containing 0.1% fetal calf
serum. A solution of the test compound in dimethyl sulfoxide was
added to each well, and the incuvation was continued at 37.degree.
C. for additional one hr. The medium was removed, the cells were
washed with phosphate buffered saline (pH 7.4), and 50 .mu.l of a
lysis buffer (20 mM HEPES (pH 7.4), 150 mM NaCl, 0.2% Triton X-100,
10% glycerol, 5 mM sodium orthovanadylate, 5 mM disodium
ethylenediaminetetraacetate, and 2 mM Na.sub.4P.sub.2O.sub.7) was
then added thereto. The mixture was shaken at 4.degree. C. for 2 hr
to prepare a cell extract.
[0723] Separately, phosphate buffered saline (50 .mu.l, pH 7.4)
containing 5 .mu.g/ml of anti-phospho-tyrosine antibody (PY20;
purchased from Transduction Laboratories) was added to a microplate
for ELISA (Maxisorp; purchased from NUNC), followed by gentle
agitation at 4.degree. C. overnight to coat the surface of the
wells with the antibody. After washing of the plate, 300 .mu.l of a
blocking solution was added, followed by gentle agitation at room
temperature for 2 hr to perform blocking. After washing, the whole
quantity of the cell extract was transferred to the wells, and the
plate was then allowed to stand at 4.degree. C. overnight. After
washing, an anti-HGF receptor antibody (h-Met (C-12), purchased
from Santa Cruz Biotechnology) was allowed to react at room
temperature for one hr, and, after washing, a peroxidase-labeled
anti-rabbit Ig antibody (purchased from Amersham) was allowed to
react at room temperature for one hr. After washing, a chromophoric
substrate for peroxidase (purchased from Sumitomo Bakelite Co.,
Ltd.) was added thereto to initiate a reaction. After a suitable
level of color development, a reaction termination solution was
added to stop the reaction, and the absorbance at 450 nm was
measured with a microplate reader. The met phosphorylation activity
for each well was determined by presuming the absorbance with the
addition of the vehicle to be 100% met phosphorylation activity and
the absorbance with the addition of a largely excessive amount of
positive control (compound 1, 1000 nM) to be 0% met phosphorylation
activity. The concentration of the test compound was varied on
several levels, the inhibition (%) of met-phosphorylation was
determined for each case, and the concentration of the test
compound necessary for inhibiting 50% of met phosphorylation
(IC.sub.50) was calculated. The results are shown in Table 2.
TABLE-US-00004 TABLE 2 Ex. No. IC.sub.50, .mu.M 1 0.0112 2 0.0181 3
0.0304 4 0.0750 5 0.0189 6 0.0316 7 0.2922 8 0.2976 9 0.0364 10
0.1459 11 0.0202 12 0.1990 13 0.1411 14 0.2909 15 0.3017 16 0.0328
17 0.0307 18 0.1496 19 0.1040 20 0.0318 21 0.1876 22 0.0246 23
0.0263 24 0.0277 25 0.1401 26 0.1256 27 0.0800 28 0.1624 29 0.0371
30 0.0351 31 0.0341 32 0.1709 33 0.0618 34 0.0463 35 0.0414 36
0.1982 37 0.0584 38 0.0291 39 0.1145 40 0.2421 41 0.2807 42 0.1899
43 0.1674 44 0.2915 45 0.2071 46 0.2290 47 0.2153 48 0.2240 49
0.0514 50 0.2355 51 0.2035 52 0.1706 53 0.0374 54 0.0261 55 0.2449
56 0.1400 57 0.1320 58 0.0270 59 0.1930 60 0.0370 61 0.1130 62
0.0920 63 0.0244 64 0.1405 65 0.0663 66 0.0792 67 0.0197 68 0.1944
69 0.0044 70 0.0153 71 0.0299 72 0.0279 73 0.0281 74 0.1825 75
0.0336 76 0.0517 77 0.1776 78 0.0663 79 0.1454 80 0.0302 81 0.0277
82 0.0743 83 0.0391 84 0.0400 85 0.0488 86 0.0235 87 0.1983 88
0.0492 89 0.0526 90 0.0281 91 0.0401 92 0.1480 93 0.1215 94 0.0307
95 0.0413 96 0.1706 97 0.0376 98 0.0278 99 0.0256 100 0.0308 101
0.0444 102 0.0918 103 2.7714 104 0.3442 105 0.1037 106 0.0427 107
0.3450 108 2.0800 109 1.4756 110 2.3751 111 1.8118 112 1.7334 113
0.6535 114 0.4850 115 0.3592 116 0.3440 117 1.3037 118 0.2114 119
0.4420 120 1.5748 121 0.3380 122 0.3026 123 2.0088 124 0.2643 125
0.2933 126 0.3295 127 0.3189 128 0.2847 129 1.0060 130 2.1555 131
2.3731 132 0.2683 133 0.2610 134 0.2319 135 0.2260 136 0.3417 137
0.2707 138 0.2843 139 0.2432 140 0.2288 141 0.3361 142 0.2847 143
3.5910 144 0.6990 145 0.3640 146 1.2100 147 1.1660 148 2.4790 149
0.2360 150 1.2780 151 0.2561 152 0.2475 153 0.2320 154 0.8760 155
0.9820 156 0.3730 157 0.4820 158 0.4650 159 0.5850 160 1.6327 161
0.2460 162 0.2096 163 0.2018 164 0.2417 165 0.4950 166 0.3183 167
0.2586 168 0.3056 169 0.2759 170 0.2736 171 0.2817 172 0.4228 173
0.2217 174 0.2522 175 0.9552 176 0.2211 177 0.2672 178 0.2680 179
0.2613 180 2.5610 181 0.2431 182 0.2559 183 0.2238 184 0.2677 185
0.2477 186 0.2340 187 0.2575 188 0.2525 189 0.2323 190 0.2237 191
0.9767 192 0.6874 193 0.4442 194 0.3188 195 0.2914 196 0.3219 197
0.2842 198 0.2938 199 0.2415 200 0.3052 201 0.2255 202 0.6416 203
0.2813 204 0.3209 205 0.2651 206 0.4436 207 0.2998 208 0.2580 209
0.9285 210 0.2277 211 0.2521 212 0.3787 213 2.4266 214 2.5273 215
1.9770 216 0.2278 217 0.3331 218 0.4793 219 0.7359 220 0.2967 221
0.2212 222 0.2014 223 0.2680 224 0.3160 225 0.2814 226 3.2308 227
4.3638 228 0.3936 229 0.2730 230 0.3403 231 0.3288 232 0.2557 233
0.3217 234 0.4568 235 0.2146 236 0.2351 237 1.4669 238 4.0204 239
1.5818 240 2.7412 241 3.3169 242 0.8512 243 3.0098 244 0.3419 245
0.3082
246 2.9114 247 0.6502 248 0.9569 249 0.5256 250 0.4474 251 0.3862
252 0.3005 253 1.3400 254 0.3655 255 0.2601 256 0.2808 257 0.2859
258 0.3574 259 0.6143 260 2.2325 261 0.3426 262 0.2689 263 0.4835
264 0.3472 265 0.2589 266 0.1806 267 0.1091 268 0.0228 269 0.0125
270 0.0267 271 0.0391 272 0.0336 273 0.0240 275 0.0230 276 0.0190
277 0.0204 278 0.0251 279 0.0204 282 0.0166 283 0.0146 284 0.0150
285 0.0753 286 0.0293 287 0.0225 288 0.0226 289 0.0238 291 0.0195
292 0.0203 293 0.0211 294 0.0230 295 0.0241 296 0.0197 297 0.0532
298 0.0890 299 0.0435 300 0.0224 301 0.0611 302 0.0231 303 0.0267
304 0.0659 305 0.0214 306 0.0339 307 0.0574 308 0.0214 309 0.0201
310 0.0211 311 0.0185 312 0.0191 313 0.0211 314 0.0232 315 0.0210
316 0.1882 317 0.0422 318 0.0283 319 0.1267 320 0.0140 321 0.1248
322 0.0426 323 <0.0100 324 0.0234 325 0.0185 326 0.0131 327
0.7978 328 0.0432 329 0.0518 330 0.0206 331 0.0220 332 0.0142 333
0.0211 334 0.0227 335 0.0236 336 0.0328 337 0.0220
Pharmacological Test Example 3
Tumor Growth Inhibitory Activity Against Human Gastric Cancer Cells
(MKN 45)
[0724] Human gastric cancer cells (MKN 45) were transplanted into
nude mice. When the tumor volume became about 100 to 200 mm.sup.3,
the mice were grouped so that the groups each consisted of five
mice and had an even average tumor volume. The test compound
suspended in 0.5% methylcellulose was orally administered twice a
day for 5 days.
[0725] Only 0.5% methylcellulose was administered to the control
group in the manner as in the test groups. The tumor growth
inhibition rate (TGIR) was calculated as follows: The tumor growth
inhibition rate (TGIR)=(1-TX/CX).times.100 wherein CX represents
the relative tumor volume at day X for the control group when the
tumor volume at the day of the start of the administration was
presumed to be 1; and TX represents the relative tumor volume for
test compound administration groups.
[0726] The tumor growth inhibition rate for representative examples
of a group of compounds according to the present invention is shown
in Table 3.
TABLE-US-00005 TABLE 3 Dose, mg/kg/time TGIR, % Example 1 10 21 30
47 100 54 Example 2 10 31 30 65 Example 3 10 24 30 52 Example 11 10
23 30 52 Example 268 30 81
Pharmacological Test Example 4
Tumor Growth Inhibitory Activity Against Human Brain Tumor Cells
(U87MG)
[0727] Human brain tumor cells (U87MG) were transplanted into nude
mice. When the tumor volume became about 100 to 200 mm.sup.3, the
mice were grouped so that the groups each consisted of five mice
and had an even average tumor volume. The test compound suspended
in 0.5% methylcellulose was orally administered twice a day for 5
days.
[0728] Only 0.5% methylcellulose was administered to the control
group in the manner as in the test groups. The tumor growth
inhibition rate (TGIR) was calculated as follows: The tumor growth
inhibition rate (TGIR)=(1-TX/CX).times.100 wherein CX represents
the relative tumor volume at day X for the control group when the
tumor volume at the day of the start of the administration was
presumed to be 1; and TX represents the relative tumor volume for
test compound administration groups.
[0729] The tumor growth inhibition rate for representative examples
of a group of compounds according to the present invention is shown
in Table 4.
TABLE-US-00006 TABLE 4 Dose, mg/kg/time TGIR, % Example 1 30 42 100
70 Example 2 10 38 30 61 Example 3 30 51 100 60
Pharmacological Test Example 5
Tumor Growth Inhibitory Activity Against Various Human Tumor
Cells
[0730] Human gastric cancer cells (MKN 45) (obtained from RIKEN),
human brain tumor cells (U87MG) (obtained from ATCC), human
pancreatic cancer cells (KP4) (obtained from RIKEN), human
pancreatic cancer cells (SUIT-2) (obtained from National Kyushu
Cancer Center), and human signet-ring type gastric cancer cells
(NUGC-4) (obtained from RIKEN), or human lung cancer cells (LC6)
(obtained from Central Laboratories for Experimental Animals) were
transplanted into nude mice. When the tumor volume became about 100
mm.sup.3, the mice were grouped so that the groups each consisted
of four or five mice and had an even average tumor volume. The test
compound suspended in 0.5% methylcellulose was orally administered
once or twice a day for 5 days. Only 0.5% methylcellulose was
administered to the control group in the manner as in the test
groups. Alternatively, the test compound dissolved in physiological
saline (with a 1 N aqueous hydrochloric acid solution added
thereto) was intraveneously injected once a day for 5 days, and
only physiological saline (with a 1 N aqueous hydrochloric acid
solution added thereto) was administered to the control group in
the same manner as in the test groups. The tumor growth inhibition
rate (TGIR) was calculated as follows: The tumor growth inhibition
rate (TGIR)=(1-TX/CX).times.100 wherein CX represents the relative
tumor volume at the 5.sup.th day for the control group when the
tumor volume at the day of the start of the administration was
presumed to be 1; and TX represents the relative tumor volume for
test compound administration groups.
[0731] The tumor growth inhibition rate for representative examples
of a group of compounds according to the present invention is shown
in Table 5.
TABLE-US-00007 TABLE 5 Ex. Administration Dose, mg/kg .times. No.
Tumor method number of times TGIR, % 1 LC6 Oral 30 .times. 2 26 2
NUGC-4 Oral 30 .times. 2 75 2 LC6 Oral 30 .times. 2 27 2 KP-4 Oral
30 .times. 2 54 3 NUGC-4 Oral 30 .times. 2 71 3 LC6 Oral 30 .times.
2 18 3 KP-4 Oral 30 .times. 2 31 11 MKN45 Oral 30 .times. 2 63 11
U87MG Oral 30 .times. 2 62 11 LC6 Oral 30 .times. 2 26 46 MKN45
Oral 25 .times. 1 38 268 MKN45 i.v. injection 10 .times. 1 52 268
LC6 Oral 30 .times. 2 35 268 U87MG Oral 30 .times. 2 74 277 MKN45
Oral 30 .times. 2 17 282 MKN45 Oral 30 .times. 2 13 282 MKN45 i.v.
injection 10 .times. 1 31 285 MKN45 Oral 30 .times. 2 66 285 LC6
Oral 30 .times. 2 48 286 MKN45 Oral 30 .times. 2 64 286 LC6 Oral 30
.times. 2 37 286 U87MG Oral 30 .times. 2 66 288 MKN45 Oral 30
.times. 2 64 299 MKN45 Oral 25 .times. 1 14 312 MKN45 Oral 30
.times. 2 75 313 MKN45 Oral 12.5 .times. 1 37 313 MKN45 Oral 25
.times. 1 73 313 MKN45 Oral 50 .times. 1 78 313 MKN45 i.v.
injection 10 .times. 1 68 313 SUIT-2 Oral 25 .times. 1 28 313 KP-4
Oral 12.5 .times. 1 34 313 KP-4 Oral 25 .times. 1 45 313 KP-4 Oral
50 .times. 1 48 314 MKN45 Oral 30 .times. 2 38 315 MKN45 Oral 30
.times. 2 36 320 MKN45 Oral 30 .times. 2 20 323 MKN45 Oral 30
.times. 2 34 326 MKN45 Oral 30 .times. 2 17 331 MKN45 Oral 30
.times. 2 40 332 MKN45 Oral 30 .times. 2 14 333 MKN45 Oral 30
.times. 2 75 334 MKN45 Oral 30 .times. 2 65
* * * * *