U.S. patent application number 12/084839 was filed with the patent office on 2008-10-30 for device and method for preparing filament yarn of composite nanofibers.
Invention is credited to Xinsong Li, Fuqian Sun, Chen Yao.
Application Number | 20080265469 12/084839 |
Document ID | / |
Family ID | 36765742 |
Filed Date | 2008-10-30 |
United States Patent
Application |
20080265469 |
Kind Code |
A1 |
Li; Xinsong ; et
al. |
October 30, 2008 |
Device and Method for Preparing Filament Yarn of Composite
Nanofibers
Abstract
Device and method for preparing filament yarn of composite
nanofibers. The device includes pairs of electrospinning nozzles on
a frame and filament guiding roller pair under the frame. The
spouts of each pair of nozzles are oppositely facing. The method
includes feeding polymer solutions to the pairs of nozzles,
applying high DC voltage with opposite polarity respectively to
each one of the pairs of nozzles, forming composite nanofibers by
attracting nanofibers with opposite charge from each nozzle and
striking together of the charged nanofibers, pulling/stretching the
composite nanofibers to form filament yarn of composite nanofibers,
drawing down the filament yarn of composite nanofibers from the
first pair of nozzles and using it as a carrier to receive the
nanofibers with opposite charge electrospun from the second pair of
nozzles and coated by the same so as to form multi-layer (e.g.,
two- or more-layer) filament yarn of composite nanofibers.
Inventors: |
Li; Xinsong; (Nanjing,
CN) ; Yao; Chen; (Nanjing, CN) ; Sun;
Fuqian; (Nanjing, CN) |
Correspondence
Address: |
CHRISTIE, PARKER & HALE, LLP
PO BOX 7068
PASADENA
CA
91109-7068
US
|
Family ID: |
36765742 |
Appl. No.: |
12/084839 |
Filed: |
November 10, 2006 |
PCT Filed: |
November 10, 2006 |
PCT NO: |
PCT/CN2006/003014 |
371 Date: |
May 9, 2008 |
Current U.S.
Class: |
264/433 ;
425/66 |
Current CPC
Class: |
D01F 8/00 20130101; D01D
5/0061 20130101 |
Class at
Publication: |
264/433 ;
425/66 |
International
Class: |
D01D 5/00 20060101
D01D005/00 |
Foreign Application Data
Date |
Code |
Application Number |
Nov 11, 2005 |
CN |
200510095384.0 |
Claims
1-9. (canceled)
10. A device for preparing filament yarn of composite nanofibers,
comprising: pairs of electrospinning nozzles, a filament guiding
roller pair, a frame, fixed sticks and a base, wherein the pairs of
electrospinning nozzles are oppositely disposed in two columns and
fixed on the frame, the frame is connected to the base by the fixed
sticks extending perpendicularly from the base, the filament
guiding roller pair is located in a plane of the frame with
substantially the same distance away from two spouts of each of the
pairs of electrospinning nozzles, and the frame is set at an
adjustable acute angle to the fixed sticks.
11. A device for preparing filament yarn of composite nanofibers
according to claim 10, wherein distance between two neighbouring
electrospinning nozzles of the pairs of electrospinning nozzles on
a same column of the frame is from about 2 to about 50 cm.
12. A device for preparing filament yarn of composite nanofibers
according to claim 10, wherein distance between two oppositely
disposed spouts of a pair of the pairs of electrospinning nozzles
is from about 10 to about 100 cm.
13. A method for preparing filament yarn of composite nanofibers
with a device for preparing the filament yarn of the composite
nanofibers, comprising: pairs of electrospinning nozzles, a
filament guiding roller pair, a frame, fixed sticks and a base,
wherein the pairs of electrospinning nozzles are oppositely
disposed in two columns and fixed on the frame, the frame is
connected to the base by the fixed sticks extending perpendicularly
from the base, the filament guiding roller pair is located in a
plane of the frame with substantially the same distance away from
two spouts of each of the pairs of electrospinning nozzles, and the
frame is set at an adjustable acute angle to the fixed sticks, the
method comprising: feeding polymer solutions to the pairs of
electrospinning nozzles on the frame; applying high electrical
voltages with opposite polarities to two oppositely disposed
electrospinning nozzles of the pairs of electrospinning nozzles,
respectively; forming composite nanofibers by attracting and
striking nanofibers with opposite charge from each of the pairs of
electrospinning nozzles together during a journey of the nanofibers
in the air, or by attracting and depositing the nanofibers on a
polymer fibrous carrier drawn down, the composite nanofibers are
pulled and/or stretched, resulting in continuous filament yarn of
the composite nanofibers; drawing down the filament yarn of the
composite nanofibers fabricated by a first pair of the pairs of
electrospinning nozzles and using the drawn down filament as a
carrier to receive the nanofibers with opposite charge electrospun
out from a second pair of the pairs of electrospinning nozzles, the
filament yarn of the composite nanofibers is then drawn down and/or
stretched, forming two-layer filament yarn of composite nanofibers;
and drawing down, in turn, filament yarn of composite nanofibers
fabricated by a former pair of the pairs of electrospinning nozzles
and using the drawn down filament as a carrier to receive the
nanofibers with opposite charge electrospun out from a latter pair
of the pairs of the electrospinning nozzles, the filament yarn of
composite nanofibers is then drawn down and/or stretched by the
filament guiding roller pair, forming multi-layer filament yarn of
composite nanofibers.
14. A method for preparing filament yarn of composite nanofibers
according to claim 13, wherein the high electrical voltages with
opposite polarities respectively applied to the two oppositely
disposed electrospinning nozzles of the pairs of electrospinning
nozzles are fixed at a voltage ranging from about 3 to about 200
kV.
15. A method for preparing filament yarn of composite nanofibers
according to claim 13, wherein the multi-layer filament yarn is
composed of various layers of polymer nanofibers.
16. A method for preparing filament yarn of composite nanofibers
according to claim 13, wherein the multi-layer filament yarn is
composed of various layers of polymer nanofibers with a polymer
fibrous carrier as a core filament yarn.
17. A method for preparing filament yarn of composite nanofibers
according to claim 13, wherein the polymer solutions fed to the
pairs of electrospinning nozzles comprise the same or are different
polymer solutions.
18. A method for preparing filament yarn of composite nanofibers
according to claim 13, wherein the polymer solutions fed to the
pairs of electrospinning nozzles comprise additive-containing
polymer solutions.
19. A method for preparing filament yarn of composite nanofibers
according to claim 13, wherein the polymer solutions fed to the
pairs of electrospinning nozzles comprise a mixture of inorganic
particles and polymer solutions.
20. A method for preparing filament yarn of composite nanofibers
according to claim 17, wherein the polymers comprise a material
selected from the group consisting of polyolefin,
halogen-substituted polyolefin, silicone, polyether, polyamide,
polyester, polycarbonate, polyurethane, epoxy resin,
polyacrylonitrile, polyacrylates, polyphenyl ether, polyanhydride,
poly(.alpha.-amine acid), polyphenyl sulfide ether, and mixtures
thereof.
21. A method for preparing filament yarn of composite nanofibers
according to claim 17, wherein the polymers comprise a material
selected from the group consisting of cellulose, dextran, silk
fibroin, chitin, hyaluronic acid, collagen, sodium alginate,
calcium alginate, chondroitin sulphate, agar, fibril protein,
keratin, casein, albumin, elastin, derivatives thereof, and
mixtures thereof.
22. A method for preparing filament yarn of composite nanofibers
according to claim 17, wherein the polymers comprise a material
selected from the group consisting of bioabsorbable synthetic
polymers, such as poly-L-lactic acid, poly-(D,L)-lactic acid, poly
glycolic acid, polycaprolactone, polybutyrolactone,
polyvalerolactone, poly-p-dioxanon, polyanhydride,
poly(.alpha.-amine acid), and combinations thereof.
23. A method for preparing filament yarn of composite nanofibers
according to claim 17, wherein the polymers comprise a copolymer
synthesized from two or more monomers selected from the group
consisting of L-lactic acid, D, L-lactic acid, glycolic acid,
3-hydroxyl butanoic acid, 3-hydroxyl pentanoic acid, caprolactone,
butyrolactone, valerolactone, amine acid, and mixtures thereof.
24. A method for preparing filament yarn of composite nanofibers
according to claim 19, wherein the inorganic particles comprise
nano-antibacterial agents.
25. A method for preparing filament yarn of composite nanofibers
according to claim 19, wherein the inorganic particles comprise
catalysts.
26. A method for preparing filament yarn of composite nanofibers
according to claim 19, wherein the inorganic particles comprise
carbon nanotubes.
27. A method for preparing filament yarn of composite nanofibers
according to claim 18, wherein the additive-containing polymer
solutions comprise additives selected from the group consisting of
antibiotics, immunosuppressants, antibacterial agents, hormone,
vitamin, amino acids, peptides, proteins, enzymes, growth factor,
dope, hemostasis agents, anodyne, anti-hyperpiesia agents and
anti-tumour agents, and mixtures thereof.
28. A method for preparing filament yarn of composite nanofibers
with a device for preparing the filament yarn of the composite
nanofibers, comprising: pairs of electrospinning nozzles, a
filament guiding roller pair, a frame, fixed sticks and a base,
wherein the pairs of electrospinning nozzles are oppositely
disposed in two columns and fixed on the frame, the frame is
connected to the base by the fixed sticks extending perpendicularly
from the base, the filament guiding roller pair is located in a
plane of the frame with substantially the same distance away from
two spouts of each of the pairs of electrospinning nozzles, and the
frame is set at an adjustable acute angle to the fixed sticks, the
method comprising: feeding polymer solutions to the pairs of
electrospinning nozzles on the frame; applying high electrical
voltages with opposite polarities to two oppositely disposed
electrospinning nozzles of the pairs of electrospinning nozzles,
respectively; forming composite nanofibers by attracting and
striking nanofibers with opposite charge from each of the pairs of
electrospinning nozzles together; pulling and stretching the
composite nanofibers to form filament yarn of the composite
nanofibers; and drawing down the filament yarn of the composite
nanofibers fabricated by a first pair of the pairs of
electrospinning nozzles and using the drawn down filament as a
carrier to receive the nanofibers with opposite charge electrospun
out from a second pair of the pairs of electrospinning nozzles; and
drawing down and stretching the filament yarn of the composite
nanofibers by the filament guiding roller pair to form multi-layer
filament yarn of composite nanofibers.
29. A method for preparing filament yarn of composite nanofibers
according to claim 28, further comprising: drawing down filament
yarn of composite nanofibers fabricated by the second pair of the
pairs of electrospinning nozzles and using the drawn down filament
as a carrier to receive the nanofibers with opposite charge
electrospun out from a third pair of the pairs of the
electrospinning nozzles; and drawing down and stretching the
filament yarn of composite nanofibers by the filament guiding
roller pair to form the multi-layer filament yarn of composite
nanofibers.
Description
CROSS-REFERENCE TO RELATED APPLICATION(S)
[0001] is application is a National Phase Patent Application and
claims the priority of International Application Number
PCT/CN2006/003014, filed on Nov. 10, 2006, which claims priority of
Chinese Patent Application Number 200610095384.0, filed on Jan. 11,
2006.
FIELD OF THE TECHNOLOGY
[0002] The present invention relates to device and method for
preparing filament yarn of composite nanofibers. It belongs to the
technical field of manufacturing special fibers.
BACKGROUND OF THE INVENTION
[0003] With social development and improvement of people's lives,
fiber industry has faced great challenges in recent years as single
components could not meet the requirement of fibers with more
functions. Various types of composite fibers have been developed,
such as core-sheath, filling, bilateral, sea-island and other types
of composite fibers. US Patent (No. 4,717,325) designed a spinneret
assembly with composite feed plates. Passages are aligned with the
orifices in the first plate and feed core material. Each core
material passage is surrounded by several feed passages for sheath
material, forming core-sheath type composite fibers.
[0004] Electrospinning, an efficient and versatile method that uses
an electric field to manufacture polymer nanofibers, has attracted
more and more attention. Electrospun fibers have large porosity and
high surface area to volume ratio, making them excellent candidates
for a number of applications as high efficient filters, biomedical
materials, chemical sensors, protective materials, nano-composite
materials, etc.
[0005] However, there exist problems of fiber loss and unstable
dispersion due to the nano-/micro-meter size of the electrospun
fibers, and repellent force between nanofibers carried charges with
same polarity. Electrospun nanofibers are often collected as
randomly oriented structures in the form of nonwoven mats. It is
difficult to manufacture continuous nanofiber yarns or
filaments.
[0006] Although tremendous progress has been made in the
fabrication of aligned nanofibers by electrospinning, a major
challenge remains in the search for an efficient means to
manufacture continuous aligned filament yarns. Electrospun fibers
can be aligned more or less parallel to each other when a drum
rotating at high speed is used as the collector. Another method is
to deposit nanofibers into water to eliminate the charges of
nanofibers which are collected together, and yarns are drawn out.
Others obtain aligned fiber yarns by linking and twisting the
electrospun nanofibers deposited on the steel drum.
[0007] Therefore, it is necessary to invent a more efficient method
to prepare filament yarn of composite nanofibers.
SUMMARY OF THE INVENTION
[0008] The present invention is to provide device and method for
preparing filament yarn of composite nanofibers which can
manufacture filament yarn of composite nanofibers simply and
efficiently.
Technical Process
[0009] Device for preparing filament yarn of composite nanofibers,
comprising: pairs of electrospinning nozzles, filament guiding
roller pair, frame, fixed sticks and base. Two columns of
oppositely disposed pairs of electrospinning nozzles are fixed on
frame. Each pair of electrospinning nozzles is in either same or
different planes. The frame is connected to base by vertical fixed
sticks. Filament guiding roller pair is located in the plane of
frame with same distance away from two spouts of each
electrospinning nozzles pair. The frame is set at an adjustable
acute angle to the fixed sticks. The roller pair is at the end of
pairs of electrospinning nozzles. Distance between two neighbouring
electrospinning nozzles on the same column of frame is 2-50 cm.
Distance between two spouts of oppositely disposed pair of
electrospinning nozzles is 10-100 cm. Plane of frame is set at
angle of 0-90.degree. to fixed sticks. The detailed procedures for
preparing filament yarn of composite nanofibers are as follows:
1) Polymer solutions are fed to pairs of electrospinning nozzles on
frame. 2) High electrical voltages with opposite polarities are
applied to two oppositely disposed pairs of electrospinning
nozzles, respectively. 3) Nanofibers with opposite charges from
each pair of electrospinning nozzles attract and strike together
during the journey in the air, or the nanofibers attract and
deposit on polymer fibrous carrier drawn down, forming composite
nanofibers. The composite nanofibers are pulled and/or stretched,
resulting in continuous filament yarn of composite nanofibers. 4)
The filament yarn of composite nanofibers fabricated by the first
pair of electrospinning nozzles are drawn down and used as a
carrier to receive the nanofibers with opposite charge electrospun
out from the second pair of nozzles. The coated filament yarn of
composite nanofibers is then drawn down and/or stretched, forming
two-layer filament yarn of composite nanofibers. 5) In turn,
filament yarn of composite nanofibers fabricated by former pair of
electrospinning nozzles are drawn down and used as a carrier to
receive the nanofibers with opposite charge electrospun out from
latter pair of nozzles. The coated filament yarn of composite
nanofibers is then drawn down and/or stretched by filament guiding
roller pair 2, forming multi-layer filament yarn of composite
nanofibers.
[0010] High electrical voltages with opposite polarities applied to
two oppositely disposed pairs of electrospinning nozzles are fixed
at 3-200 kV, respectively. Polymer solutions fed to electrospinning
nozzles are polymer solutions, additive-containing polymer
solutions, or mixture of inorganic particles and polymer solutions.
Polymers are any of polyolefin, halogen-substituted polyolefin,
silicone, polyether, polyamide, polyester, polycarbonate,
polyurethane, epoxy resin, polyacrylonitrile, polyacrylic acid,
polyacrylates, polyphenyl ether, polyanhydride, poly(.alpha.-amine
acid), polyphenyl sulfide ether, or mixtures of above two or more
polymers, or any of cellulose, cellulose derivatives, dextran, silk
fibroin, chitosan, chitosan derivatives, hyaluronic acid,
hyaluronic acid derivatives, collagen, carrageenan, sodium
alginate, calcium alginate, chondroitin sulphate, gelatin, agar,
dextran, fibril, fibrinogen, keratin, casein, albumin, elastin, or
their derivatives or mixtures of above two or more polymers, or any
of bioabsorbable synthetic polymers, such as poly-L-lactic acid,
poly-(D,L)-lactic acid, poly glycolic acid, polycaprolactone,
polybutyrolactone, polyvalerolactone, poly-p-dioxane,
polyanhydride, poly(.alpha.-amine acid), or copolymer synthesized
from two or more monomers as follows: L-lactic acid, D, L-lactic
acid, glycolic acid, 3-hydroxyl butanoic acid, 3-hydroxyl pentanoic
acid, caprolactone, butyrolactone, valerolactone, amine acid, or
mixtures of above two or more polymers. Inorganic particles are
nano-antibacterial agents, catalysts, or carbon nanotubes.
[0011] Additives are any of antibiotics, immunosuppressants,
antibacterial agents, hormone, vitamin, amino acids, peptides,
proteins, enzymes, growth factor, antibacterial drugs, dope,
hemostasis agents, anodyne, anti-hyperpiesia agents and anti-tumour
agents, or mixtures of above two or more agents.
ADVANTAGES
[0012] The present invention has following advantages:
(1) The present invention utilizes a method for preparing filament
yarn of composite nanofibers, where electrospinning nozzles
oppositely disposed are electrically charged by high DC voltages
with opposite polarities. Nanofibers electrospun from the two
nozzles which carry charges with opposite polarities attract each
other, strike together, and neutralize their charges. The present
method shows a less dispersion and loss of nanofibers in the air.
Furthermore, grounded metal collector used in conventional
electrospinning method is unnecessary in the present invention. (2)
In the present invention, frame is set at an adjustable acute angle
to fixed sticks to avoid any slightly disturbed or unstable
spinning jet. (3) The present invention can manufacture filament
yarn of composite nanofibers simply and efficiently. (4) In the
present invention, different polymer solutions or
additive-containing polymer solutions can be fed to two spouts of
electrospinning nozzles pair oppositely disposed respectively,
resulting in the formation of composite filament yarn of
multi-component nanofibers. (5) In the present invention, filament
yarn of composite nanofibers with different composition and
nano-structure can be produced by the use of multiple pairs of
electrospinning nozzles. Thicker multi-layer filament yarn of
composite nanofibers may exhibit good mechanical properties. (6) In
the present invention, nanofibers from oppositely disposed
electrospinning nozzles which carry charges with opposite
polarities can deposit on polymer fiber carrier, and then drawn
down by filament guiding roller pair set under frame with a less
dispersion or loss of nanofibers. And, multi-layer filament yarn of
composite nanofibers with polymer fiber carrier as core is produced
having excellent mechanical properties. (7) The present invention
can produce filament yarns of composite nanofibers including
nano-particles as combined with electro-spraying technique. (8) The
present invention can manufacture filament yarn of composite
nanofibers having potential applications in tissue engineered
scaffolds and textiles, etc.
BRIEF DESCRIPTION OF THE DRAWINGS
[0013] FIG. 1 is structure scheme of the present invention.
[0014] FIG. 2 is principle scheme of the present invention.
[0015] The two figures include pairs of electrospinning nozzles 1,
filament guiding roller pair 2, frame 3, fixed sticks 4 and base
5.
[0016] FIG. 3 is photograph of PLLA filament yarns of composite
nanofibers.
[0017] FIG. 4 is photograph of PLLA filament yarns of composite
nanofibers.
[0018] FIG. 5 is SEM image of PLLA filament yarns of composite
nanofibers.
[0019] FIG. 6 is SEM image of PU/PVDF filament yarn of composite
nanofibers.
[0020] FIG. 7 is SEM image of PAN filament yarn of composite
nanofibers.
[0021] FIG. 8 is SEM image of PVDF filament yarn of composite
nanofibers.
DETAILED DESCRIPTION OF THE INVENTION
[0022] Device for preparing filament yarn of composite nanofibers,
comprising: pairs of electrospinning nozzles 1, filament guiding
roller pair 2, frame 3, fixed sticks 4 and base 5. Two columns of
oppositely disposed pairs of electrospinning nozzles 1 are fixed on
frame 3. Each pair of electrospinning nozzles is in either same or
different planes. The frame 3 is connected to base 5 by vertical
fixed sticks 4. Filament guiding roller pair 2 is located in the
plane of frame 3 with same distance away from two spouts of each
electrospinning nozzles pair. The roller pair 2 is at the end of
pairs of electrospinning nozzles 1. The frame 3 is set at an
adjustable acute angle to the fixed sticks 4.
[0023] The detailed procedures for preparing filament yarn of
composite nanofibers are as follows:
1) Polymer solutions are fed to pairs of electrospinning nozzles 1
on frame 3. 2) High electrical voltages with opposite polarities
are applied to two oppositely disposed pairs of electrospinning
nozzles 1, respectively. 3) Nanofibers with opposite charge from
each pair of electrospinning nozzles attract and strike together
during the journey in the air, forming composite nanofibers. The
composite nanofibers are pulled and/or stretched, resulting in
continuous filament yarn of composite nanofibers. 4) The filament
yarn of composite nanofibers fabricated by the first pair of
electrospinning nozzles are drawn down and used as a carrier to
receive the nanofibers with opposite charge electrospun out from
the second pair of nozzles. The coated filament yarn of composite
nanofibers is then drawn down and/or stretched, forming two-layer
filament yarn of composite nanofibers. 5) In turn, filament yarn of
composite nanofibers fabricated by former pair of electrospinning
nozzles are drawn down and used as a carrier to receive the
nanofibers with opposite charge electrospun out from latter pair of
nozzles. The coated filament yarn of composite nanofibers is then
drawn down and/or stretched by filament guiding roller pair 2,
forming multi-layer filament yarn of composite nanofibers.
[0024] The detailed procedures for preparing filament yarn of
composite nanofibers can also be: 1) Polymer solutions are fed to
pairs of electrospinning nozzles 1 on frame 3. 2) High electrical
voltages with opposite polarities are applied to two oppositely
disposed pairs of electrospinning nozzles 1, respectively. 3)
Nanofibers with opposite charge from each pair of electrospinning
nozzles 1 attract and deposit on polymer fibrous carrier drawn
down, forming composite nanofibers. The composite nanofibers are
pulled and/or stretched, resulting in continuous filament yarn of
composite nanofibers.
[0025] Distance between two neighbouring electrospinning nozzles 1
on the same column of frame 3 is 2-50 cm. Distance between two
spouts of oppositely disposed pair of electrospinning nozzles 1 is
10-100 cm. Plane of frame 3 is set at angle of 0-90.degree. to
fixed sticks 4. High electrical voltages with opposite polarities
applied to two oppositely disposed pairs of electrospinning nozzles
1 are fixed at 5-200 kV, respectively.
[0026] Polymer solutions fed to electrospinning nozzles are polymer
solutions, additive-containing polymer solutions, or mixture of
inorganic particles and polymer solutions. Polymers are any of
polyolefin, halogen-substituted polyolefin, silicone, polyether,
polyamide, polyester, polycarbonate, polyurethane, epoxy resin,
polyacrylonitrile, polyacrylic acid, polyacrylates, polyphenyl
ether, polyanhydride, poly(.alpha.-amine acid), polyphenyl sulfide
ether, or mixtures of above two or more polymers, or any of
cellulose, cellulose derivatives, dextran, silk fibroin, chitosan,
chitosan derivatives, hyaluronic acid, hyaluronic acid derivatives,
collagen, carrageenan, sodium alginate, calcium alginate,
chondroitin sulphate, gelatin, agar, dextran, fibril, fibrinogen,
keratin, casein, albumin, elastin, or their derivatives or mixtures
of above two or more polymers, or any of bioabsorbable synthetic
polymers, such as poly-L-lactic acid, poly-(D,L)-lactic acid, poly
glycolic acid, polycaprolactone, polybutyrolactone,
polyvalerolactone, poly-p-dioxane, polyanhydride,
poly(.alpha.-amine acid), or copolymer synthesized from two or more
monomers as follows: L-lactic acid, D, L-lactic acid, glycolic
acid, 3-hydroxyl butanoic acid, 3-hydroxyl pentanoic acid,
caprolactone, butyrolactone, valerolactone, amine acid, or mixtures
of above two or more polymers. Inorganic particles are
nano-antibacterial agents, catalysts, or carbon nanotubes.
Additives are any of antibiotics, immunosuppressants, antibacterial
agents, hormone, vitamin, amino acids, peptides, proteins, enzymes,
growth factor, antibacterial drugs, dope, hemostasis agents,
anodyne, anti-hyperpiesia agents and anti-tumour agents, or
mixtures of above two or more agents.
[0027] The present invention can manufacture filament yarn of
composite nanofibers having potential applications in regeneration
medicine and textiles, etc.
EXAMPLE 1
[0028] A device for electrospinning is used comprising frame 3
having three pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 90.degree.
to fixed sticks 4.
[0029] 10 g poly-L-lactic acid (PLLA, M.eta.=100,000 g/mol) was
dissolved in a mixed solvent of 50 ml acetone and 50 ml
N,N-dimethyl formamide, and the prepared solution was fed to one
column of electrospinning nozzles containing 3 spinnerets. 15 g
poly-lactide-co-glycolide (Poly-LA-co-GA, PLGA, weight ratio of
LA:GA=50:50, M.eta.=100,000 g/mol) was dissolved in a mixed solvent
of 50 ml acetone and 50 ml N,N-dimethyl formamide, and the prepared
solution was fed to the other column of electrospinning nozzles
containing 3 spinnerets. Distance between two neighbouring
electrospinning nozzles on the same column of frame 3 is 15 cm, and
distance between two tips of oppositely disposed pair of
electrospinning nozzles is 40 cm. Plane of frame 3 is set at angle
of 90.degree. to fixed sticks 4. High DC voltages of +20 kV were
applied to two columns of oppositely disposed electrospinning
nozzles with inner diameter of 0.5 mm, respectively. Nanofibers
exiting from the electrospinning nozzles were induced and drawn out
by filament guiding roller pair which is set at the end of pairs of
electrospinning nozzles on the plane of the frame. The drawing
speed of filament guiding roller pair was 8 cm/s. And, three-layer
filament yarn of PLLA/PLGA composite nanofibers is obtained.
EXAMPLE 2
[0030] A device for electrospinning is used comprising frame 3
having four pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 90.degree.
to fixed sticks 4.
[0031] 10 g poly-L-lactic acid (PLLA, Mq=100,000 g/mol) was
dissolved in a mixed solvent of 50 ml acetone and 50 ml
N,N-dimethyl formamide, and the prepared solution was fed to one
column of electrospinning nozzles containing 4 spinnerets. 10 g
polycaprolactone (PCL, Mw=90,000 g/mol) was dissolved in 100 ml N,
N-dimethyl formamide, and the prepared solution was fed to the
other column of electrospinning nozzles containing 4 spinnerets.
Distance between two neighbouring electrospinning nozzles on the
same column of frame 3 is 15 cm, and distance between two tips of
oppositely disposed pair of electrospinning nozzles is 40 cm. Plane
of frame 3 is set at angle of 90.degree. to fixed sticks 4. High DC
voltages of .+-.20 kV were applied to two columns of oppositely
disposed electrospinning nozzles with inner diameter of 0.5 mm,
respectively. The drawing speed of filament guiding roller pair 2
was 8 cm/s. Nanofibers exiting from the electrospinning nozzles
were induced and drawn out by filament guiding roller pair 2 which
is set at the end of pairs of electrospinning nozzles on the plane
of the frame 3. And, multi-layer filament yarn of PLLA/PCL
composite nanofibers is obtained.
EXAMPLE 3
[0032] A device for electrospinning is used comprising frame 3
having three pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 90.degree.
to fixed sticks 4.
[0033] 10 g poly-L-lactic acid (PLLA, M.eta.=100,000 g/mol) was
dissolved in a mixed solvent of 50 ml acetone and 50 ml
N,N-dimethyl formamide, and the prepared solution was fed to one
column of electrospinning nozzles containing 3 spinnerets of which
inner diameter is 0.8 mm. 35 g zein (Mw=35,000 g/mol) was dissolved
in 100 ml aqueous ethanol solution with ethanol/water volume ratio
of 80/20, and the prepared solution was fed to the other column of
electrospinning nozzles containing 3 spinnerets of which inner
diameter is 1.2 mm. Distance between two neighbouring
electrospinning nozzles on the same column of frame is 15 cm, and
distance between two tips of oppositely disposed pair of
electrospinning nozzles is 40 cm. Plane of frame 3 is set at angle
of 90.degree. to fixed sticks 4. High DC voltages of +25 kV were
applied to two columns of oppositely disposed electrospinning
nozzles, respectively. The drawing speed of filament guiding roller
pair 2 was 8 cm/s. Nanofibers exiting from the electrospinning
nozzles were induced and drawn out by filament guiding roller pair
2 which is set at the end of pairs of electrospinning nozzles on
the plane of the frame 3. And, three-layer filament yarn of
PLLA/zein composite nanofibers is obtained.
EXAMPLE 4
[0034] A device for electrospinning is used comprising frame 3
having four pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 90.degree.
to fixed sticks 4.
[0035] 10 g polyacrylonitrile (PAN, Mw=130,000 g/mol) was dissolved
in 100 ml N, N-dimethyl formamide, and the prepared solution was
fed to one column of electrospinning nozzles containing 4
spinnerets. 10 g polyphenyl ether sulphone (PES, melt flow rate 3.9
g/10 min, 320.degree. C.) was dissolved in 100 ml dimethyl
sulphone, and the prepared solution was fed to the other column of
electrospinning nozzles containing 4 spinnerets. Distance between
two neighbouring electrospinning nozzles on the same column of
frame is 15 cm, and distance between two tips of oppositely
disposed pair of electrospinning nozzles is 40 cm. Plane of frame 3
is set at angle of 90.degree. to fixed sticks 4. High DC voltages
of .+-.20 kV were applied to two columns of oppositely disposed
electrospinning nozzles with inner diameter of 0.5 mm,
respectively. Nanofibers exiting from the electrospinning nozzles
were induced and drawn out by filament guiding roller pair 2 which
is set at the end of pairs of electrospinning nozzles on the plane
of the frame 3. The drawing speed of filament guiding roller pair 2
was 8 cm/s. And, multi-layer filament yarn of PAN/PPES composite
nanofibers is obtained.
EXAMPLE 5
[0036] A device for electrospinning is used comprising frame 3
having two pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0037] 10 g poly-L-lactic acid (PLLA, M11=100,000 g/mol) was
dissolved in a mixed solvent of 50 ml acetone and 50 ml N,
N-dimethyl formamide. 15 g poly-lactide-co-glycolide
(Poly-LA-co-GA, PLGA, weight ratio of LA:GA=50:50, M.eta.=100,000
g/mol) was dissolved in a mixed solvent of 50 ml acetone and 50 ml
N, N-dimethyl formamide. 15 g polyurethane (PU) was dissolved in
100 ml N, N-dimethyl formamide. 10 g polycaprolactone (PCL,
Mw=90,000 g/mol) was dissolved in 100 ml N, N-dimethyl formamide.
After complete dissolution, solutions were fed to two columns of
oppositely disposed 4 electrospinning nozzles, respectively.
Distance between two neighbouring electrospinning nozzles on the
same column of frame is 15 cm, and distance between two tips of
oppositely disposed pair of electrospinning nozzles is 40 cm. Plane
of frame 3 is set at angle of 0.degree. to fixed sticks 4. High DC
voltages of .+-.20 kV were applied to two columns of oppositely
disposed electrospinning nozzles with inner diameter of 0.8 mm,
respectively. Nanofibers exiting from the electrospinning nozzles
were induced and drawn out by filament guiding roller pair 2 which
is set at the end of pairs of electrospinning nozzles on the plane
of the frame 3. The drawing speed of filament guiding roller pair 2
was 5 cm/s. And, filament yarn of PLLA/PLGA/PU/PCL composite
nanofibers is obtained.
EXAMPLE 6
[0038] A device for electrospinning is used comprising frame 3
having three pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0039] 1 g hyaluronic acid (HA, Mw=100,000 g/mol) was dissolved in
100 ml distilled water. 0.5 g chitosan was dissolved in 100 ml 0.1
mol/L acetic acid solution. 10 g poly-L-lactic acid (PLLA,
M.eta.=100,000 g/mol) was dissolved in a mixed solvent of 50 ml
acetone and 50 ml N, N-dimethyl formamide. 15 g
poly-lactide-co-glycolide (Poly-LA-co-GA, PLGA, weight ratio of
LA:GA=50:50, M.eta.=100,000 g/mol) was dissolved in a mixed solvent
of 50 ml acetone and 50 ml N, N-dimethyl formamide. 15 g
polyurethane (PU) was dissolved in 100 ml N, N-dimethyl formamide.
10 g polycaprolactone (PCL, Mw=90,000 g/mol) was dissolved in 100
ml N, N-dimethyl formamide. After complete dissolution, solutions
were fed to two columns of oppositely disposed 6 electrospinning
nozzles, respectively. Distance between two neighbouring
electrospinning nozzles on the same column of frame is 10 cm, and
distance between two tips of oppositely disposed pair of
electrospinning nozzles is 30 cm. Plane of frame 3 is set at angle
of 0.degree. to fixed sticks 4. High DC voltages of .+-.20 kV were
applied to two columns of oppositely disposed electrospinning
nozzles with inner diameter of 0.8 mm, respectively. Nanofibers
exiting from the electrospinning nozzles were induced and drawn out
by filament guiding roller pair 2 which is set at the end of pairs
of electrospinning nozzles on the plane of the frame 3. The drawing
speed of filament guiding roller pair 2 was 5 cm/s. And, filament
yarn of HA/chitosan/PLLA/PLGA/PU/PCL composite nanofibers is
obtained.
EXAMPLE 7
[0040] A device for electrospinning is used comprising frame 3
having three pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0041] 1 g hyaluronic acid (HA, Mw=100,000 g/mol) was dissolved in
100 ml distilled water, and the prepared solution was fed to one
column of electrospinning nozzles containing 3 spinnerets. 10 g
poly-L-lactic acid (PLLA, M.eta.=100,000 g/mol) was dissolved in a
mixed solvent of 50 ml acetone and 50 ml N, N-dimethyl formamide,
and the prepared solution was fed to the other column of
electrospinning nozzles containing 3 spinnerets. Distance between
two neighbouring electrospinning nozzles on the same column of
frame is 10 cm, and distance between two tips of oppositely
disposed pair of electrospinning nozzles is 30 cm. Plane of frame 3
is set at angle of 0.degree. to fixed sticks 4. High DC voltages of
.+-.20 kV were applied to two columns of oppositely disposed
electrospinning nozzles with inner diameter of 0.8 mm,
respectively. Nanofibers exiting from the electrospinning nozzles
were induced and drawn out by filament guiding roller pair 2 which
is set at the end of pairs of electrospinning nozzles on the plane
of the frame 3. The drawing speed of filament guiding roller pair 2
was 5 cm/s. And, filament yarn of HA/PLLA composite nanofibers is
obtained.
EXAMPLE 8
[0042] A device for electrospinning is used comprising frame 3
having three pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0043] 1 g hyaluronic acid (HA, Mw=100,000 g/mol) was dissolved in
100 ml distilled water, and 0.2 g brophenol was added into the
solution. After complete dissolution of brophenol, the solution was
fed to one column of electrospinning nozzles containing 3
spinnerets. 10 g poly-L-lactic acid (PLLA, M.eta.=100,000 g/mol)
was dissolved in a mixed solvent consisting of 50 ml acetone and 50
ml N, N-dimethyl formamide, and the prepared solution was fed to
the other column of electrospinning nozzles containing 3
spinnerets. Distance between two neighbouring electrospinning
nozzles on the same column of frame is 10 cm, and distance between
two tips of oppositely disposed pair of electrospinning nozzles is
30 cm. Plane of frame 3 is set at angle of 0.degree. to fixed
sticks 4. High DC voltages of .+-.20 kV were applied to two columns
of oppositely disposed electrospinning nozzles with inner diameter
of 0.8 mm, respectively. Nanofibers exiting from the
electrospinning nozzles were induced and drawn out by filament
guiding roller pair 2 which is set at the end of pairs of
electrospinning nozzles on the plane of the frame 3. The drawing
speed of filament guiding roller pair 2 was 5 cm/s. And, filament
yarn of HA/brophenol/PLLA composite nanofibers is obtained.
EXAMPLE 9
[0044] A device for electrospinning is used comprising frame 3
having three pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0045] 10 g polyacrylonitrile (PAN) was dissolved in 100 ml N,
N-dimethyl formamide, and the prepared solution was fed to one
column of electrospinning nozzles containing 3 spinnerets. 15 g
polyurethane (PU) was dissolved in 100 ml N, N-dimethyl formamide,
and the prepared solution was fed to the other column of
electrospinning nozzles containing 3 spinnerets. Distance between
two neighbouring electrospinning nozzles on the same column of
frame is 10 cm, and distance between two tips of oppositely
disposed pair of electrospinning nozzles is 30 cm. Plane of frame 3
is set at angle of 0.degree. to fixed sticks 4. High DC voltages of
.+-.20 kV were applied to two columns of oppositely disposed
electrospinning nozzles with inner diameter of 0.8 mm,
respectively. Drawing speed of filament guiding roller pair is 5
cm/s. Nanofibers from the oppositely disposed electrospinning
nozzles which carry charges with opposite polarities deposited on
polyester fibers and then drawn out by filament guiding roller pair
2 set under frame. Multi-layer filament yarns of composite
nanofibers whose core is polyester fibers with shell of composite
PAN/PU nanofibers were drawn out and collected by the filament
guiding roller pair.
EXAMPLE 10
[0046] A device for electrospinning is used comprising frame 3
having four pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 45.degree.
to fixed sticks 4.
[0047] 10 g polyurethane (PU) was dissolved in 100 ml N, N-dimethyl
formamide, and the prepared solution was fed to one column of
electrospinning nozzles containing 4 spinnerets. 10 g
polycaprolactone was dissolved in 100 ml N, N-dimethyl formamide,
and the prepared solution was fed to the other column of
electrospinning nozzles containing 4 spinnerets. Distance between
two neighbouring electrospinning nozzles on the same column of
frame is 10 cm, and distance between two tips of oppositely
disposed pair of electrospinning nozzles is 30 cm. Plane of frame 3
is set at angle of 45.degree. to fixed sticks 4. High DC voltages
of +15 kV were applied to two columns of oppositely disposed
electrospinning nozzles with inner diameter of 1.2 mm,
respectively. Drawing speed of filament guiding roller pair 2 is 5
cm/s. Nanofibers exiting from the electrospinning nozzles were
induced and drawn out by the filament guiding roller pair,
collecting as continuous multi-layer filament yarn of PU/PCL
composite nanofibers.
EXAMPLE 11
[0048] A device for electrospinning is used comprising frame 3
having two pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0049] 10 g poly-L-lactic acid (PLLA, M.eta.=100,000 g/mol) was
dissolved in a mixed solvent of 100 ml acetone and 50 ml
N,N-dimethyl formamide, and the prepared solution was fed to the
two columns of oppositely disposed 4 electrospinning nozzles.
Distance between two neighbouring electrospinning nozzles on the
same column of frame is 15 cm, and distance between two tips of
oppositely disposed pair of electrospinning nozzles is 40 cm. Plane
of frame 3 is set at angle of 0.degree. to fixed sticks 4. High DC
voltages of .+-.20 kV were applied to two columns of oppositely
disposed electrospinning nozzles with inner diameter of 1.2 mm,
respectively. The drawing speed of filament guiding roller pair 2
was 5 cm/s. Nanofibers exiting from the electrospinning nozzles
were induced and drawn out by filament guiding roller pair 2 which
is set at the end of pairs of electrospinning nozzles on the plane
of the frame 3. And, filament yarn of PLLA composite nanofibers is
obtained.
EXAMPLE 12
[0050] A device for electrospinning is used comprising frame 3
having two pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0051] 10 g polycaprolactone (PCL) was dissolved in 100 ml N,
N-dimethyl formamide, and the prepared solution was fed to the
first pair of electrospinning nozzles. 15 g
poly-lactide-co-glycolide (Poly-LA-co-GA, PLGA, weight ratio of
LA:GA=50:50, M.eta.=100,000 g/mol) was dissolved in a mixed solvent
of 50 ml acetone and 50 ml N,N-dimethyl formamide, 0.3 g brophenol
was then added into the solution. After complete dissolution of
brophenol, the solution was fed to the second pair of
electrospinning nozzles. Distance between two neighbouring
electrospinning nozzles on the same column of frame is 15 cm, and
distance between two tips of oppositely disposed pair of
electrospinning nozzles is 30 cm. Plane of frame 3 is set at angle
of 0.degree. to fixed sticks 4. High DC voltages of +10 kV were
applied to two columns of oppositely disposed electrospinning
nozzles with inner diameter of 0.8 mm, respectively. Nanofibers
exiting from the electrospinning nozzles were induced and drawn out
by filament guiding roller pair 2 which is set at the end of pairs
of electrospinning nozzles on the plane of the frame 3. The drawing
speed of filament guiding roller pair 2 was 5 cm/s. And, two-layer
filament yarn of PCL/PLGA composite nanofibers is obtained.
EXAMPLE 13
[0052] A device for electrospinning is used comprising frame 3
having ten pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 30.degree.
to fixed sticks 4.
[0053] 50 g poly-L-lactic acid (PLLA, Mq=150,000 g/mol) was
dissolved in a mixed solvent of 250 ml acetone and 250 ml
N,N-dimethyl formamide, and the prepared solution was fed to one
column of electrospinning nozzles containing 10 spinnerets. 5 g
hyaluronic acid (HA, Mw=1,000,000 g/mol) was dissolved in 500 ml
distilled water, and the prepared solution was fed to the other
column of electrospinning nozzles containing 10 spinnerets.
Distance between two neighbouring electrospinning nozzles on the
same column of frame is 10 cm, and distance between two tips of
oppositely disposed pair of electrospinning nozzles is 30 cm.
Planes of frame and fixed sticks were set at an angle of
30.degree.. High DC voltages of .+-.50 kV were applied to two
columns of oppositely disposed electrospinning nozzles with inner
diameter of 0.8 mm, respectively. Drawing speed of filament guiding
roller pair 2 is 5 cm/s. Nanofibers exiting from the
electrospinning nozzles were induced and drawn out by the filament
guiding roller pair, collecting as continuous filament yarn of
PLLA/HA composite nanofibers with diameter of ca. 150 micros.
EXAMPLE 14
[0054] A device for electrospinning is used comprising frame 3
having three pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 30.degree.
to fixed sticks 4.
[0055] 0.5 g chitosan was dissolved in 100 ml 0.1 mol/L acetic acid
solution, and the prepared solution was fed to one column of
electrospinning nozzles containing 3 spinnerets. 10 g
polycaprolactone (PCL) was dissolved in 100 ml N, N-dimethyl
formamide, and the prepared solution was fed to the other column of
electrospinning nozzles containing 3 spinnerets. Distance between
two neighbouring electrospinning nozzles on the same column of
frame is 10 cm, and distance between two tips of oppositely
disposed pair of electrospinning nozzles is 20 cm. Planes of frame
and fixed sticks were set at an angle of 30.degree.. High DC
voltages of +20 kV were applied to two columns of oppositely
disposed electrospinning nozzles with inner diameter of 0.6 mm,
respectively. Nanofibers exiting from the electrospinning nozzles
were induced and drawn out by filament guiding roller pair 2 which
is set at the end of pairs of electrospinning nozzles on the plane
of the frame 3. The drawing speed of filament guiding roller pair 2
was 5 cm/s. And, filament yarn of chitosan/PCL composite nanofibers
is obtained.
EXAMPLE 15
[0056] A device for electrospinning is used comprising frame 3
having four pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 90.degree.
to fixed sticks 4.
[0057] 10 g polycarbonate (PC, Mw=100,000 g/mol) was dissolved in
100 ml N, N-dimethyl formamide, and the prepared solution was fed
to one column of electrospinning nozzles containing 4 spinnerets.
10 g polyphenyl ether sulphone (PES, melt flow rate 3.9 g/10 min,
320.degree. C.) was dissolved in 100 ml dimethyl sulphone, and the
prepared solution was fed to the other column of electrospinning
nozzles containing 4 spinnerets. Distance between two neighbouring
electrospinning nozzles on the same column of frame is 15 cm, and
distance between two tips of oppositely disposed pair of
electrospinning nozzles is 40 cm. Plane of frame 3 is set at angle
of 90.degree. to fixed sticks 4. High DC voltages of +20 kV were
applied to two columns of oppositely disposed electrospinning
nozzles with inner diameter of 0.5 mm, respectively. Nanofibers
exiting from the electrospinning nozzles were induced and drawn out
by filament guiding roller pair 2 which is set at the end of pairs
of electrospinning nozzles on the plane of the frame 3. The drawing
speed of filament guiding roller pair 2 was 8 cm/s. And,
multi-layer filament yarn of PC/PPES composite nanofibers is
obtained.
EXAMPLE 16
[0058] A device for electrospinning is used comprising frame 3
having four pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 30.degree.
to fixed sticks 4.
[0059] 10 g polyacrylonitrile (PAN, Mw=130,000 g/mol) was dissolved
in 100 ml N, N-dimethyl fommamide, and 0.1 g single wall carbon
nanotubes were added into the solution. After completely
homogeneous dispersion of the nanotubes by ultrasonic vibration,
the solution was fed to one column of electrospinning nozzles
containing 4 spinnerets. 10 g polyphenyl ether sulphone (PES, melt
flow rate 3.9 g/10 min, 320.degree. C.) was dissolved in 100 ml
dimethyl sulphone, and the prepared solution was fed to the other
column of electrospinning nozzles containing 4 spinnerets. Distance
between two neighbouring electrospinning nozzles on the same column
of frame is 15 cm, and distance between two tips of oppositely
disposed pair of electrospinning nozzles is 40 cm. Planes of frame
and fixed sticks were set at an angle of 30.degree.. High DC
voltages of .+-.20 kV were applied to two columns of oppositely
disposed electrospinning nozzles with inner diameter of 0.5 mm,
respectively. Drawing speed of the filament guiding roller pair is
8 cm/s. Nanofibers exiting from the electrospinning nozzles were
induced and drawn out by the filament guiding roller pair,
collecting as continuous filament yarn of single wall carbon
nanotubes and PC/PPES composite nanofibers.
EXAMPLE 17
[0060] A device for electrospinning is used comprising frame 3
having three pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0061] 1 g hyaluronic acid (HA, Mw=100,000 g.mu.mol) was dissolved
in 100 ml distilled water, and 10 mg bone morphogenetic protein
were added into the solution. After completely dissolution of the
bone morphogenetic protein, the solution was fed to one column of
electrospinning nozzles containing 3 spinnerets. 10 g poly-L-lactic
acid (PLLA, M.eta.=100,000 g/mol) was dissolved in a mixed solvent
of 50 ml acetone and 50 ml N,N-dimethyl formamide, and the prepared
solution was fed to the other column of electrospinning nozzles
containing 3 spinnerets. Distance between two neighbouring
electrospinning nozzles on the same column of frame is 10 cm, and
distance between two tips of oppositely disposed pair of
electrospinning nozzles is 30 cm. Plane of frame 3 is set at angle
of 0.degree. to fixed sticks 4. High DC voltages of .+-.20 kV were
applied to two columns of oppositely disposed electrospinning
nozzles with inner diameter of 0.8 mm, respectively. Nanofibers
exiting from the electrospinning nozzles were induced and drawn out
by filament guiding roller pair 2 which is set at the end of pairs
of electrospinning nozzles on the plane of the frame 3. The drawing
speed of filament guiding roller pair 2 was 5 cm/s. And, filament
yarn of HA/PLLA composite nanofibers is obtained.
EXAMPLE 18
[0062] A device for electrospinning is used comprising frame 3
having two pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0063] 20 g poly-L-lactic acid (PLLA, M.eta.=100,000 g/mol) was
dissolved in a mixed solvent of 100 ml acetone and 50 ml
N,N-dimethyl formamide, and 1 g .beta.-tricalcium phosphate
(.beta.-TCP) nano-particles with diameters of ca. 300 nm were added
into the solution. After completely homogeneous dispersion of the
nano-particles by ultrasonic vibration, the solution was fed to two
columns of oppositely disposed 4 electrospinning nozzles. Distance
between two neighbouring electrospinning nozzles on the same column
of frame is 15 cm, and distance between two tips of oppositely
disposed pair of electrospinning nozzles is 40 cm. Plane of frame 3
is set at angle of 0.degree. to fixed sticks 4. High DC voltages of
.+-.50 kV were applied to two columns of oppositely disposed
electrospinning nozzles with inner diameter of 1.2 mm,
respectively. Nanofibers exiting from the electrospinning nozzles
were induced and drawn out by filament guiding roller pair 2 which
is set at the end of pairs of electrospinning nozzles on the plane
of the frame 3. The drawing speed of filament guiding roller pair 2
was 5 cm/s. And, filament yarn of PLLA/.beta.-TCP composite
nanofibers is obtained.
EXAMPLE 19
[0064] A device for electrospinning is used comprising frame 3
having twenty-five pairs of electrospinning nozzles 1 in two
columns, filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0065] 100 g poly-L-lactic acid (PLLA, M.eta.=150,000 g/mol) was
dissolved in a mixed solvent of 500 ml acetone and 500 ml
N,N-dimethyl formamide, and the prepared solution was fed to one
column of electrospinning nozzles containing 25 spinnerets. 10 g
hyaluronic acid (HA, Mw--1,000,000 g/mol) was dissolved in 1000 ml
distilled water, and the prepared solution was fed to the other
column of electrospinning nozzles containing 25 spinnerets.
Distance between two neighbouring electrospinning nozzles on the
same column of frame is 2 cm, and distance between two tips of
oppositely disposed pair of electrospinning nozzles is 40 cm. Plane
of frame 3 is set parallel to fixed sticks 4. High DC voltages of
.+-.120 kV were applied to two columns of oppositely disposed
electrospinning nozzles with inner diameter of 1.2 mm,
respectively. Drawing speed of the filament guiding roller pair 2
is 10 cm/s. Nanofibers exiting from the electrospinning nozzles
were induced and drawn out by the filament guiding roller pair,
collecting as continuous filament yarn of PLLA/HA composite
nanofibers with diameter of ca. 200 micros.
EXAMPLE 20
[0066] A device for electrospinning is used comprising frame 3
having ten pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0067] 50 g poly-L-lactic acid (PLLA, M=150,000 g/mol) was
dissolved in a mixed solvent of 250 ml acetone and 250 ml
N,N-dimethyl formamide, and the prepared solution was fed to two
columns of oppositely disposed 20 electrospinning nozzles. Distance
between two neighbouring electrospinning nozzles on the same column
of frame is 8 cm, and distance between two tips of oppositely
disposed pair of electrospinning nozzles is 40 cm. Plane of frame 3
is set parallel to fixed sticks 4. High DC voltages of +80 kV were
applied to two columns of oppositely disposed electrospinning
nozzles with inner diameter of 1.2 mm, respectively. Drawing speed
of filament guiding roller pair 2 is 5 cm/s. Nanofibers exiting
from the electrospinning nozzles were induced and drawn out by the
filament guiding roller pair, collecting as continuous PLLA
composite nanofiber yarns with diameter of ca. 100 micros.
EXAMPLE 21
[0068] A device for electrospinning is used comprising frame 3
having two pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0069] 10 g poly-L-lactic acid (PLLA, M11=150,000 g/mol) was
dissolved in a mixed solvent of 50 ml acetone and 50 ml
N,N-dimethyl formamide, and the prepared solution was fed to one
column of electrospinning nozzles containing 2 spinnerets. 1.5 g
collagen was dissolved in 30 ml hexafluoro-2-propanol (HFIP), and
the prepared solution was fed to the other column of
electrospinning nozzles containing 2 spinnerets. Distance between
two neighbouring electrospinning nozzles on the same column of
frame is 10 cm, and distance between two tips of oppositely
disposed pair of electrospinning nozzles is 30 cm. Plane of frame 3
is set parallel to fixed sticks 4. High DC voltages of .+-.30 kV
were applied to two columns of oppositely disposed electrospinning
nozzles with inner diameter of 1.2 mm, respectively. The drawing
speed of filament guiding roller pair 2 was 3 cm/s. Nanofibers
exiting from the electrospinning nozzles were induced and drawn out
by filament guiding roller pair 2 which is set at the end of pairs
of electrospinning nozzles on the plane of the frame 3. And,
filament yarn of PLLA/collagen composite nanofibers is
obtained.
EXAMPLE 22
[0070] A device for electrospinning is used comprising frame 3
having two pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 30.degree.
to fixed sticks 4.
[0071] 10 g poly (vinylidenefluoride) (PVDF) was dissolved in a
mixed solvent of 50 ml acetone and 50 ml N, N-dimethyl formamide,
and the prepared solution was fed to two columns of oppositely
disposed 4 electrospinning nozzles. Distance between two
neighbouring electrospinning nozzles on the same column of frame is
15 cm, and distance between two tips of oppositely disposed pair of
electrospinning nozzles is 40 cm. Plane of frame 3 is set at angle
of 30.degree. to fixed sticks 4. High DC voltages of .+-.30 kV were
applied to two columns of oppositely disposed electrospinning
nozzles with inner diameter of 1.2 mm, respectively. The drawing
speed of filament guiding roller pair 2 was 3 cm/s. Nanofibers
exiting from the electrospinning nozzles were induced and drawn out
by filament guiding roller pair 2 which is set at the end of pairs
of electrospinning nozzles on the plane of the frame 3. And,
filament yarn of PVDF composite nanofibers is obtained.
EXAMPLE 23
[0072] A device for electrospinning is used comprising frame 3
having two pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0073] 10 g poly (vinylidenefluoride) (PVDF) was dissolved in a
mixed solvent of 50 ml acetone and 50 ml N, N-dimethyl formamide,
and the prepared solution was fed to one column of electrospinning
nozzles containing 2 spinnerets. 15 g polyurethane (PU) was
dissolved in 100 ml N, N-dimethyl formamide, and the prepared
solution was fed to the other column of electrospinning nozzles
containing 2 spinnerets. Distance between two neighbouring
electrospinning nozzles on the same column of frame is 10 cm, and
distance between two tips of oppositely disposed pair of
electrospinning nozzles is 30 cm. Plane of frame 3 is set parallel
to fixed sticks 4. High DC voltages of .+-.20 kV were applied to
two columns of oppositely disposed electrospinning nozzles with
inner diameter of 1.2 mm, respectively. The drawing speed of
filament guiding roller pair 2 was 3 cm/s. Nanofibers exiting from
the electrospinning nozzles were induced and drawn out by filament
guiding roller pair 2 which is set at the end of pairs of
electrospinning nozzles on the plane of the frame 3. And, filament
yarn of PVDF/PU composite nanofibers is obtained.
EXAMPLE 24
[0074] A device for electrospinning is used comprising frame 3
having two pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0075] 10 g poly-L-lactic acid (PLLA, M11=150,000 g/mol) was
dissolved in a mixed solvent of 50 ml acetone and 50 ml
N,N-dimethyl formamide, and the prepared solution was fed to one
column of electrospinning nozzles containing 2 spinnerets. 10 g
poly (vinyl pyrrolidone) (PVP K30, BASF) was dissolved in 50 ml
acetone, and the prepared solution was fed to the other column of
electrospinning nozzles containing 2 spinnerets. Distance between
two neighbouring electrospinning nozzles on the same column of
frame is 10 cm, and distance between two tips of oppositely
disposed pair of electrospinning nozzles is 30 cm. Plane of frame 3
is set parallel to fixed sticks 4. High DC voltages of .+-.20 kV
were applied to two columns of oppositely disposed electrospinning
nozzles with inner diameter of 1.2 mm, respectively. The drawing
speed of filament guiding roller pair 2 was 3 cm/s. Nanofibers
exiting from the electrospinning nozzles were induced and drawn out
by filament guiding roller pair 2 which is set at the end of pairs
of electrospinning nozzles on the plane of the frame 3. And,
filament yarn of PLLA/PVP composite nanofibers is obtained.
EXAMPLE 25
[0076] A device for electrospinning is used comprising frame 3
having three pairs of electrospinning nozzles 1 in two columns,
filament guiding roller pair 2 set at the end of pairs of
electrospinning nozzles. The frame 3 was set at angle of 0.degree.
to fixed sticks 4.
[0077] 10 g poly-L-lactic acid (PLLA, M.eta.=100,000 g/mol) was
dissolved in a mixed solvent of 50 ml acetone and 50 ml N,
N-dimethyl formamide. 15 g poly-lactide-co-glycolide
(Poly-LA-co-GA, PLGA, weight ratio of LA:GA=50:50, M.eta.=100,000
g/mol) was dissolved in a mixed solvent of 50 ml acetone and 50 ml
N, N-dimethyl formamide. 1 g hyaluronic acid (HA, Mw=100,000 g/mol)
was dissolved in 100 ml distilled water. 0.3 g chitosan was
dissolved in 100 ml 0.1 mol/L acetic acid solution. 1.5 g collagen
was dissolved in hexafluoro-2-propanol (HFIP). 10 g
polycaprolactone (PCL, Mw=90,000 g/mol) was dissolved in 100 ml N,
N-dimethyl formamide. After complete dissolution, solutions were
fed to two columns of oppositely disposed 6 electrospinning
nozzles, respectively. Distance between two neighbouring
electrospinning nozzles on the same column of frame is 10 cm, and
distance between two tips of oppositely disposed pair of
electrospinning nozzles is 30 cm. Plane of frame 3 is set parallel
to fixed sticks 4. High DC voltages of +15 kV were applied to two
columns of oppositely disposed electrospinning nozzles with inner
diameter of 0.8 mm, respectively. Filament yarn of composite
nanofibers fabricated by former pair of electrospinning nozzles are
drawn out and subsequently wrapped around composite nanofibers from
latter pair of two oppositely charged electrospinning nozzles. The
nanofibers are then drawn out and/or stretched by filament guiding
roller pair, forming filament yarn of composite nanofibers.
* * * * *