U.S. patent application number 12/097066 was filed with the patent office on 2008-10-23 for hair growth stimulants and the manufacturing method thereof.
Invention is credited to Jong Hyun Nam.
Application Number | 20080260867 12/097066 |
Document ID | / |
Family ID | 38163094 |
Filed Date | 2008-10-23 |
United States Patent
Application |
20080260867 |
Kind Code |
A1 |
Nam; Jong Hyun |
October 23, 2008 |
Hair Growth Stimulants and the Manufacturing Method Thereof
Abstract
A hair growth stimulant having excellent hair growth stimulation
and hair growth effects without any side effects, which contains a
carbonized pine cone. The inventive hair growth stimulant has an
excellent hair growth stimulation effect without causing any side
effects or toxicity to the human body, while it can stimulate hair
roots to greatly influence the growth of hair so as to prevent hair
loss and white hair. Also, it can be provided in the form of creams
or ointments having an excellent effect on hair growth stimulation,
and thus can considerably shorten a treatment period. It can keep
the anagen-stage hair by increasing the blood flow of the scalp,
and it consists of a vegetable preparation, and so has no side
effects to the human body. In addition, it can be used through
smooth application to a head, and thus is easy to use.
Inventors: |
Nam; Jong Hyun; (Seoul,
KR) |
Correspondence
Address: |
IPHORGAN, LTD.
1130 LAKE COOK ROAD, SUITE 240
BUFFALO GROVE
IL
60089
US
|
Family ID: |
38163094 |
Appl. No.: |
12/097066 |
Filed: |
February 10, 2006 |
PCT Filed: |
February 10, 2006 |
PCT NO: |
PCT/KR2006/000486 |
371 Date: |
June 12, 2008 |
Current U.S.
Class: |
424/725.1 ;
424/725 |
Current CPC
Class: |
A61P 17/14 20180101;
A61K 8/9767 20170801; A61K 8/9789 20170801; A61K 8/9794 20170801;
A61P 29/00 20180101; A61P 31/04 20180101; A61K 8/922 20130101; A61Q
7/00 20130101 |
Class at
Publication: |
424/725.1 ;
424/725 |
International
Class: |
A61K 36/15 20060101
A61K036/15; A61K 36/00 20060101 A61K036/00; A61Q 7/00 20060101
A61Q007/00 |
Foreign Application Data
Date |
Code |
Application Number |
Dec 12, 2005 |
KR |
10-2005-0121967 |
Claims
1. A hair growth stimulant comprising, as active ingredients, a
carbonized pine cone and vegetable oil.
2. The hair growth stimulant of claim 1, which is prepared by
mixing the carbonized pine cone and the vegetable oil with each
other at a weight ratio of 1:1 to 6:4.
3. The hair growth stimulant of claim 1, wherein the vegetable oil
is seed oil.
4. The hair growth stimulant of claim 1, wherein the vegetable oil
is at least one selected from the group consisting of sesame oil,
olive oil, perilla oil, coconut oil, castor oil, bean oil and
Cuscutae Semen oil.
5. The hair growth stimulant of claim 1, which additionally
comprises at least one herbal medicinal extract selected from the
group consisting of apricot seed, acorn, pomegranate, gromwell,
pasque flower and licorice extracts.
6. The hair growth stimulant of claim 1, wherein the herbal
medicinal extract is a solvent extract prepared by extracting each
of the herbal materials with hot water, organic solvent or oil.
7. The hair growth stimulant of claim 1, wherein the solvent
extract is used after dilution, concentration or drying.
8. The hair growth stimulant of claim 6, wherein the gromwell
extract is prepared by heating sesame oil to a temperature of
100-300.degree. C. and then adding 10-30 wt % of the gromwell to
the heated sesame oil.
9. The hair growth stimulant of claim 6, wherein the pomegranate
extract is prepared by adding 5-25 wt % of a pomegranate to sesame
oil and storing the mixture at a temperature of 30-50.degree. C.
for 1-30 days.
10. The hair growth stimulant of claim 6, wherein the pasque flower
extract is prepared by indirectly heating a pasque flower at
100-300.degree. C. to obtain a carbonized material and adding 80-90
wt % of sesame oil to the carbonized material.
11. The hair growth stimulant of claim 6, wherein the carbonized
pine cone, the vegetable oil and the herbal medicinal extract are
used at a mixing weight ratio of 1:1:1 to 3:4:3.
12. The hair growth stimulant of claim 5, wherein the carbonized
pine cone, the vegetable oil, the apricot seed extract, the acorn
extract and the licorice extract are used at a mixing weight ratio
of 10-70:10-50:5-20:5-20:10-15.
13. The hair growth stimulant of claim 5, wherein the carbonized
pine cone, the vegetable oil, the apricot seed extract, the acorn
extract, the gromwell extract and licorice extract are mixed with
each other at a weight ratio of
10-70:5-40:10-30:5-20:5.about.20:5-20.
14. The hair growth stimulant of claim 1, wherein the carbonized
pine cone is obtained by washing a screened pine cone with water,
drying the washed material, and completely burning the dried
material by heating in a closed container at a temperature of
100-300.degree. C.
15. The hair growth stimulant of claim 1, which additionally
comprises at least one adjuvant selected from among a blood flow
stimulant, a counter irritant, a follicle restorer, and an
anti-inflammatory and antibacterial agent.
16. The hair growth stimulant of claim 1, which is in the form of a
preparation for local application, hair lotion, hair cream, hair
gel, hair rinse or essence.
17. The hair growth stimulant of claim 16, wherein the preparation
of local application is in the form of ointments or creams.
18. A method for preparing a hair growth stimulant, comprising the
steps of: preparing a carbonized pine cone; collecting sesame oil;
mixing the carbonized pine cone and the sesame oil with each other;
and adding an excipient to the mixture of the carbonized pine cone
and the sesame oil.
19. The method of claim 18, which additionally comprises the step
of preparing an herbal medicinal extract.
20. The method of claim 18, wherein the carbonized pine cone is
obtained by completely burning a pine cone in a closed container at
a temperature of 100-300.degree. C. for 1-8 hours.
Description
TECHNICAL FIELD
[0001] The present invention relates to a hair growth stimulant and
a preparation method thereof, and a hair growth stimulant having
excellent hair stimulation and hair growth effects without side
effects or toxicity, which comprises a carbonized pine cone, as
well as a preparation method thereof.
BACKGROUND ART
[0002] So far as known, hair loss is caused by various factors,
including a reduction in hair function by testosterone, a reduction
in the metabolic function of the hair root, a reduction in the
physiological function of a head, a reduction in regional cerebral
blood flow that causes abnormal hair growth due to a reduction in
the peripheral vascular blood flow of subcutaneous tissue of a
head, nutritional deficiency, stresses, drug side effects, and
genetic factors.
[0003] Hair or the skin plays an important role to show the
function of human organs and the condition of the human body. Hair
determines a beautiful effect in individuals and personal
appearance or image, and at the present time, hair conditions are
impaired due to nutritional deficiency, the excessive intake of
instant food, etc.
[0004] Hair grows about 0.3-0.4 mm a day by an excess of blood, but
white hair or hair loss conditions appear due to various
environmental factors as described above.
[0005] Common men lose hair during the catagen and telogen stages
after the anagen stage for 4.about.5 years, and women lose hair
during the catagen and telogen stages after the anagen stage for
5.about.6 years.
[0006] Alopecias are divided according to the cause of hair loss
into many kinds, including genetic alopecia, alopecia seborrhecia,
alopecia greata, alopecia by nutritional deficiency, alopecia by
drug side effects, alopecia by fungi, alopecia by insufficient
adaptation to environmental changes, neurotic alopecia, etc.
[0007] However, in most of these alopecias, the scalp becomes warm
in an initial stage and have inflammatory protrusions occurred
thereon, so that hair becomes thin and loses elasticity while it
falls out.
[0008] Commercially available hair growth stimulants include
vasodilators such as carpronium chloride, minoxidil and various
extracts, hormones for inhibiting testosterone action such as
esterogen or estragiol, and testosterone activity inhibitors such
as pentadecanoic acid or finasteride. Hormones for inhibiting
testosterone, and testosterone inhibitors have a problem of
insufficient clinical effects or side effects of inhibiting male
sexual function. Also, hair growth stimulant compositions
containing various extracts cause a problem of skin abnormality
upon application to the skin.
[0009] Developed and sold drugs for the treatment and prevention of
alopecia include hair growth stimulants, such as a minoxidil
preparation approved by USA FDA, and finasteride (proscar) for oral
administration, inhibiting the action of 5-alpha-reductase to
inhibit the production of dihydrotestosterone. However, these drugs
are expensive and have problems in use, such as a reduction in
effects when applied directly to the scalp, and side effects when
administered orally.
[0010] Accordingly, there is a continued need for the development
of a hair growth stimulant which has an excellent effect of
preventing hair loss and is easy to use while not causing side
effects, such as skin abnormality and the inhibition of male sexual
function.
DISCLOSURE OF THE INVENTION
[0011] Accordingly, the present inventors have conducted studies to
develop a hair growth stimulant which can maximize hair loss
prevention and hair growth effects by completely removing
follicular impurities and fatty materials, the main causes of hair
loss, and rapidly regenerating follicular cells.
[0012] As a result, the present inventors have developed a hair
growth stimulant that eliminates the use of hormones capable of
causing side effects, contain a natural substance harmless to the
human body while having good sensory feel, and shows surprising
effects, thereby completing the present invention.
[0013] It is an object of the present invention to provide a hair
growth stimulant having an excellent hair growth effect without
causing side effects or toxicity to the human body, which is based
on natural substances, a carbonized pine cone and an herbal
medicinal extract, as well as a preparation method thereof.
[0014] To achieve the above object, the present invention provides
a hair growth stimulant containing as active ingredients a
carbonized pine cone and vegetable oil.
[0015] The hair growth stimulant according to the present invention
can be prepared by mixing the carbonized pine cone and the
vegetable oil at a weight ratio of 1:1 to 6:4.
[0016] The vegetable oil may be at least one selected from the
group consisting of sesame oil, olive oil, perilla oil, coconut
oil, castor oil, bean oil and seed oil.
[0017] The hair growth stimulant may additionally comprise at least
one herbal medicinal extract selected from the group consisting of
an apricot seed, an acorn, gromwell, a pomegranate, a pasqueflower
and licorice.
[0018] As the herbal medicinal extract, a solvent extract by
extracting said herbal material with hot water, organic solvent or
oil can be used.
[0019] The gromwell extract can be prepared by heating sesame oil
at a temperature of 100-300 C and adding and concentrating gromwell
in the heated sesame oil in an amount of 10-30 wt % based on the
weight of the sesame oil.
[0020] The pomegranate extract can be prepared by adding
pomegranate in an amount of 5-25 wt % to sesame oil and storing the
mixture at 30-50 C for 1-30 days.
[0021] The pasqueflower extract can be prepared by indirectly
heating a pasqueflower at a temperature of 100-300 C and adding
sesame oil in an amount of 80-90 wt % to the carbonized
material.
[0022] The solvent extract can be used after dilution,
concentration or drying.
[0023] The hair growth stimulant according to the present invention
can be prepared by mixing the carbonized pine cone, the vegetable
oil and the herbal medicinal extract with each other at a ratio of
1:1:1 to 3:4:3.
[0024] According to one embodiment of the present invention, the
carbonized pine cone, the vegetable oil, the apricot seed extract,
the acorn extract and the licorice extract can be at a mixing
weight ratio of 10-70:10-50:5-20:5-20:10-15.
[0025] According to another embodiment of the present invention,
the carbonized pine cone, the vegetable oil, the apricot seed
extract, the acorn extract, the gromwell extract and licorice
extract can be used at a mixing weight ratio of
10-70:5-40:10-30:5-20:5.about.20:5-20.
[0026] Also, the hair growth stimulant according to the present
invention may additionally comprise adjuvants such as a blood flow
stimulant, a counter irritant, a follicle restorer, and
anti-inflammatory and antibacterial agents.
[0027] The carbonized pine cones can be obtained by washing
carefully selected pine cones with water, drying the washed
material, and completing burning the dried material by heating in a
closed container at a temperature of 100-300 C for 1-8 hours.
[0028] In another aspect, the present invention provides a method
for preparing a hair growth stimulant, comprising the steps of:
preparing a carbonized pine cone; preparing sesame oil; mixing the
carbonized pine cone and the sesame oil with each other; and adding
an excipient to the mixture.
[0029] The inventive method for preparing the hair growth stimulant
may additionally comprise the step of preparing an herbal medicinal
extract.
[0030] The carbonized pine cone can be obtained by completely
burning a pine cone in a closed container at 100-300 C for 3-10
hours.
BEST MODE FOR CARRYING OUT THE INVENTION
[0031] The pine cone which is used as a main component in the
present invention as described above is a pine seed growing at a
pine tree. The pine tree is also called Sol, Chamsol, Songmok,
Solnamoo, Sohorinamu in Korea. The pine tree is also called a red
pine tree since its bark and a bud at the end of its shoot are red
in color. In China, it is also called female pine, Yodong red pine,
and short-leaf red pine. The pine tree is bifoliate, where two
leaves form a couple. It is also called Isoosong, Ichimsong
(denoting two-needle pine), Iripsong, etc. The scientific term of
the pine tree is Pinus densiflora Siebold et Zuccarini. When the
pine seed sprouts, cotyledons covered with the testa will come out
above earth, and the number of the cotyledons is about 4 to 9 and
is 6 in most cases. Pine leaves deviating the cotyledons form a
couple and come out with one confronting the other and the bottom
portion is in the vagina that is about 2 or 3 mm in size. The
vagina is dark brown and is alive as long as the leaves live,
without falling down. Meanwhile, there are female and male flowers
in pine, which bloom in the last ten days of April and the first
ten days of May. The male flower is elliptical and 4 to 9 mm in
length. The end of the stamen spreads in the shape of the half moon
and there are two anthers below filements. There are two wings in
pollen. Meanwhile, the female flower is hung 2 or 3 at the end of
the branch. The initial shape is circular or elliptical and is
about 5 mm in length and is light violet in color. This is a
collection of a multitude of female flowers, which is called a
cone. This is what is called a pine cone in the present invention.
Mature pine cones consist of various scaly leaves, and in a scaly
leaf, two ovules are in contact, which later on become a seed with
two wings. Young cones in spring before pollination are called
storbile or conelet in English, instead of cones. Scaly leaves of
the pine cone is in contact with the axis of the pine cone
helically, its end is fat and big, its exposed part is near the
diamond shape, and there is a protrusion in its center. When the
pine cone is mature, the gap between scaly leaves become bigger and
the seeds are fallen apart and come flying out.
[0032] The pine cone that is a raw material for preparing the
carbonized pine cone can be collected from various pine trees.
Examples of pine trees from which the pine cone can be collected
include forma aurescens, forma anguina, var globosa, forma pendula,
forma aggregata, forma bi-aggergata, forma erecta, etc.
[0033] The sesame is an annual plant growing to a height of 90-150
cm and has short fuzz and long oval-shaped or willow leaf-like
leaves that adhere while looking at each other. It has a soft
eggplant-like color or a white color in summer while it contains
seeds having colors varying depending on its varieties. The seeds
are collected by cutting the stems in August or September when the
fruits ripened, drying the cut stems in a bundle in the sunlight,
shaking the dried stems to collect the seeds and removing foreign
matter. The black seed is use as a drug, and the white seed is used
as the raw material of oil. Oil squeezed from the dried seeds is
used and this oil is slightly yellow in color and smells fragrant.
It is miscible with ether, chloroform and petroleum ether and
slightly dissolved in alcohol. Also, it hardens upon cooling at 0-5
C. Also, it has a specific gravity of about 0.9, a refractive index
of about 1.5, an acid number of 2 or less, a saponification number
of 188-195, and an iodine number of 103-116. Also, it contains
glycerides such as oleic acid, linoleic acid, palmitic acid,
stearic acid, arachidonic acid, lignoserinic acid. The
non-saponified portions of the oil is present in an amount of
0.1-1.3% and include pytosterine, d-sesamine, sesamol, sesamoline,
and vitamin E. Sesamol shows a red color by furfurol and
concentrated hydrochloric acid, and this reaction is used to
identify sesame oil. The effects of sesame are widely known also in
the prior medical books. Particularly, black sesame has plain
properties and is sweet and innoxious (Dongeuibogam). Also, it
increases vigor, grows fat, replenishes marrow and brain tissue,
strengthens muscles and bones, and softens the five viscera
(Bongchogangmok). Also, it builds up marrow, replenishes sperm,
extends life span, and makes a face color look younger. The black
sesame oil acts to increase blood platelet so as to rapidly
coagulate blood. Accordingly, it is sometimes used against
idiopathic thrombocytopenia, haemorrhagic thrombocytopenia, and
hemorrhagic diseases.
[0034] The apricot seed is Armeniacae Semen that is a kind of a
biosynthetic drug showing analgesic and anti-inflammatory
effects.
[0035] The acorn is the fruit of Quercus Acutissima Carruthers
belonging to the family Fagaceae and wildly in all the areas in
Korea except for Pyungannamdo. It is distributed in Japan, China,
Manchuria, and India, and it flowers in May and has a spherical
fruit and a dish-shaped cupule and ripens in October. The acorn is
characterized by containing 6-9% of tannin having a puckery taste,
unlike other fruits. This tannin is known to have physiological
actions such as antioxidant, antitumor, antiviral and antiallergic
actions.
[0036] The gromwell is a perennial grass growing to a height of
30-70 cm and having strong fuzz. It has willow-like leaves that
cross each other. In early summer, it blooms a five-branched white
small flower at shoot ends and leaves which differentiate into
seeds. Its root is gathered in autumn and dried in the sunlight.
Its flower and root have a black reddish eggplant color. The root
contains napthoquinone derivatives having a red color, for example,
acetylshikonin, shikonin, isovalerylshikonin,
-dimethylacryl-shikonin, teracryl-konin,
-hydroxyisovaleryl-shikonin, methyl-n-butylshikonin, deoxyshikonin,
and anhydroalkannin, and alkannan. Also, those found in the root
include alkaloid, triterpensaponine, 1-volnesitol, inositol,
leutin, and nitrile glycoside. Its aerial parts contain
phenolcarbonic acid. In addition, it has antibacterial or
anti-inflammatory action.
[0037] The pomegranates are divided into a sweet family having a
strong sweet taste and a sour family having a strong sour taste,
and its fruit and skin all have a good effect on the prevention of
hypertension and arterial sclerosis and an effect against women s
diseases and a boil. Particularly, it shows an excellent effect
against dysentery infection and contains volatile alkaloid and thus
is used as a parasiticide, particularly as a taeniacide. Also, it
contains citric acid promoting the decomposition of glucose,
Vitamins (B1, B2, niacin) necessary to activate energy metabolism,
and minerals having a close connection with most of physiological
actions. Its leaf adheres to a long-oval fruit. Its flower has
various colors, such as a red color, an eggplant color and a white
color, and its fruit is round in shape and has a rough surface due
to knob-like shapes present on the surface, and breaks upon
ripening. The bark peeled from the stem and the root are sometimes
used, and the more fresh the bark, the higher the alkaloid content.
The root and stem bark alkaloids and ellagitannin, in which the
alkaloids include pelletierine, iso-pelletierine, methyl
iso-pelletierine (methyl isopiperidine), pseudopelletierine, and
the like. The alkaloid content varies depending on seawater where
the tree grows, and its varieties and parts, and the tannin
consists of a glycoside-like linkage of ellagic acid and glucose.
The ellagitannin will be converted into ellagic acid when
decomposed in water. In addition, its tree bark contains betulic
acid, and its fruit and leaf contain ursolic acid. Its bark
contains mannitol and equimol. Its flower pigment punicin, and its
seed contain oil based on a glyceride of punicic acid. Also, its
fruit juice contains ivert sugar and organic acid. In addition, its
fruit skin contains viscous liquid and tannin.
[0038] The pasqueflower is a perennial grass and contains anemonin
and tannin. The anemonin is contained in a fresh root in the form
of protoanemonin which is polymerized in air to form anemonin.
[0039] The licorice is a perennial grass belonging to the family
legumiinosae, and its outer bark has a reddish brown color to a
dark brown color. It is distributed in the northeastern region of
China, a Mongol region, USA, and the continent of Africa, and its
root and rhizome are used as medicinal herbs. Licorice extracted
with distilled water, ethanol or ether is known to have an
excellent antioxidant effect, and contains a large amount of
flavonoids which can be separated into 30 kinds of compounds. The
effects of licorice flavonoids, which have been found so far,
include antioxidant effect, radical reducing effect, antibacterial
effect, antiulcer effect, cough relief effect, antimutagenic
effect, and antiviral effect. Glycyrrizine which is one of the
typical components contained in the root of licorice is the sweet
component of licorice and present as a white to lemon yellow
crystal. In addition to a strong sweet taste, the glycyrrizine has
various pharmacological effects.
[0040] The hair growth stimulant according to the present invention
can be prepared by mixing the carbonized pine cone as a main
component with vegetable oil. Also, the hair growth stimulant may
additionally comprise an herbal medicinal extract obtained from the
apricot seed, the acorn, the gromwell, the pomegranate, the
pasqueflower and the licorice, as well as an adjuvant, such as a
blood flow stimulant, a counter irritant, a follicle restorer, and
an anti-inflammatory and antibacterial agent. The carbonized pine
cone can be obtained by washing a carefully selected pine cone with
water, drying the washed material, completely burning the dried
pine cone by heating in a closed container at 100-300 C for 3-10
hours, and then sieving the carbonized material through a 50-200
mesh sieve.
[0041] As the herbal medicinal extract, a solvent extract obtained
by extracting an herbal medicinal material selected from among
apricot seeds, acorns and licorice with hot water, organic solvent
or oil can be used. Also, these solvent extracts may be used after
dilution, concentration or drying. The extraction can be performed
using a solvent at room temperature or elevated temperature.
Alternatively, it can be performed using an extraction device such
as soxhlet. The organic solvent used in the extraction process is
not specifically limited and can be exemplified by known solvents,
including lower alcohols such as methanol or ethanol, liquid
polyhydric alcohols such as propylene glycol or 1,3-butylene
glycol, and lower alkyl ester such as ethyl acetate. These solvents
may be used alone or a mixture of two or more.
[0042] Preferably, a raw material selected from among the apricot
seed, the acorn and the licorice is extracted at 60-120 C for 1-8
hours and the extract is concentrated to 12-60 Brix at low
temperatures.
[0043] According to one embodiment of the present invention, the
gromwell extract can be prepared by heating sesame oil at a
temperature of 100-300 C and adding and concentrating the gromwell
in the heated sesame oil in an amount of 10-30 wt % based on weight
of the sesame.
[0044] According to one embodiment of the present invention, the
pomegranate extract can be prepared by adding the pomegranate in an
amount of 5-25 wt % to sesame oil and storing the mixture at a
temperature of 30-50 C for 1-30 days.
[0045] According to one embodiment of the present invention, the
pasqueflower extract can be prepared by indirectly heating the
pasqueflower at a temperature of 100-300 C and adding sesame oil in
an amount of 80-90 wt % to the resulting carbonized material.
[0046] As the vegetable oil, seed oil, such as sesame oil, olive
oil, perilla oil, bean oil, grape seed oil, caster oil, and
Cuscutae Semen oil.
[0047] According to one embodiment of the present invention, sesame
oil is used as the vegetable oil.
[0048] As the sesame oil, black sesame oil or white sesame oil can
be used. The sesame oil contains a large amount of an antioxidant,
and thus does not degeneration, such as oxidation, even upon
long-term storage, and contains larger amounts of essential fatty
acids such as linolic acid, linoleic acid and arachidonic acid,
compared to other oils. These essential fatty acids are known to
prevent cell aging and white hair. Olive oil is produced in
Mediterranean areas, such as Spain, Italy and Greece, and contains
a large amount of a natural antioxidant substance.
[0049] Preferably, the inventive hair growth stimulant can be
prepared by mixing the carbonized pine cone and the vegetable oil
at a weight ratio of 1:1 to 6:4.
[0050] The hair growth stimulant according to the present invention
can be prepared by mixing the carbonized pine cone, the vegetable
oil and the herbal medicinal extract at a weight ratio of 1:1:1 to
3:4:3.
[0051] Also, the hair growth stimulant according to the present
invention can be prepared by mixing the carbonized pine cone, the
sesame oil, the apricot seed extract, the acorn extract and the
licorice extract at a weight ratio of 10-70:10-50:5-20:5-20:10-15,
but it is not limited thereto. By being prepared in this manner,
the inventive hair growth stimulant can stimulate the health and
growth of hair and can be prevented from oxidation.
[0052] Also, the inventive hair growth stimulant can stimulate the
health and growth of hair and can be prevented from oxidation, by
preparing the stimulant by mixing the carbonized pine cone, the
sesame oil, the apricot seed extract, the acorn extract, the
gromwell extract and the licorice extract at a weight ratio of
10-70:5-40:10-30:5.about.20:5-20:5.about.20, but it is not limited
thereto.
[0053] Hair grows and falls out during a cycle consisting of the
anagen, catagen and telogen stages. In this cycle, hair grows in
the anagen state and stops to grow in the catagen stage so as to
fall out. The hair growth stimulant according to the present
invention acts to stimulate the fast growth of hair, to protect
hair in the anagen stage and to make hair growing, by extending the
catagen stage and supplying nutrients to hair in the telogen stage
so as to restore the hair to the state of the initial anagen
stage.
[0054] The hair growth stimulant according to the present invention
can be formulated into any known preparations. For example, it can
be formulated into preparations for local application, such as
ointments or creams.
[0055] Also, the inventive hair growth stimulant can be used in the
form of various cosmetics for use in hair or scalp, for example,
hair lotion, hair cream, hair gel, hair rinse, and essence. Because
the prior hair lotion, hair cream, hair gel and hair rinse contain
no hair growth stimulant and provides merely a beauty effect, such
cosmetics do not greatly help hair growing and to stimulate hair
growth. However, if the hair growth stimulant according to the
present invention is included in the compositions of various hair
cosmetics, functional hair cosmetics can be prepared which can keep
more glossy and fresh hair by supplying nutrients to not only the
hairs of men and women having alpecia, to but also hair which lost
elasticity due to environmental factors or stresses.
[0056] Moreover, the inventive hair growth stimulant may, if
necessary, contain additives generally used in cosmetics or drugs,
for example, a plant extract, an oily component, a surfactant,
alcohols, fatty acids, a preservative, an antioxidant, a pigment, a
fragrance, UV absorbing agent, a viscosity adjusting agent, a
chelating agent, a pH adjusting agent, vitamins, and tablets, as
long as these additives do not adversely affect the effects of the
present invention.
[0057] The inventive ointment or cream preparation for the
stimulation of hair growth can be prepared by suitably mixing
organic acid, Vaseline and other excipients with a mixture of the
carbonized pine cone and sesame oil and/or the herbal medicinal
extract according to any general method for forming creams or
ointments. The inventive ointment or cream preparation for the
stimulation of hair growth preferably contains active ingredients,
such as the carbonized pine cone, the vegetable oil and the herbal
medicinal extract, in an amount of 0.1-30 wt %, and more preferably
5-20 wt %. If the content of the active ingredients is less than
0.1 wt %, it will have an insufficient effect on hair growth and
stimulation, and if it exceeds 30 wt %, it will cause a difficulty
in formulation and will not provide a great increase in effect
resulting from an increased use thereof.
[0058] The pH of the inventive hair growth stimulant is preferably
in a range of 4-7 in terms of safety to the human body, the
absorption of components of the hair growth stimulant into the
scalp, the prevention of decomposition, affinity for the skin,
etc.
[0059] Hereinafter, the present invention will be described in more
detail by Examples and Comparative Examples. It is to be
understood, however, that these examples are for illustrative
purpose only and are not construed to limit the scope of the
present invention.
EXAMPLE 1
[0060] Among the pine cones of a native kind of pine trees, pine
cones having the desired size were carefully selected. The selected
pine cones were washed with purified water and dried in the shade.
As the pine cones were completely dried, 1000 g of the pine cones
were placed in a completely closed container, and then completely
burned by heating at about 300 C for about 8 hours. Thereafter, the
burned pine cones were left to stand for 2 hours to cool the pine
cones, thus providing carbonized pine cones. The resulting
carbonized pine cones were sieved through a 100-mesh sieve, thus
obtaining about 800 g of carbonized pine cone powder.
[0061] Sesame was screened through a screening machine so as to
eliminate foreign matter, and the screened sesame was washed and
dried. After completion of the drying, it was roasted in a roaster
at a temperature of about 160 C until water was completely
evaporated and just before smoke would be generated. The roasted
sesame was pulverized with a pulverizer and squeezed to obtain
sesame oil.
[0062] The carbonized pine cone and the sesame oil were mixed with
each other at a weight ratio of 2:1, to which conventional
excipients were then added such that mixture of the pine cone and
the sesame oil was contained in an amount of 30 wt %. The resulting
mixture was formulated as cream according to a conventional
formulation method so as to prepare a hair growth stimulant.
EXAMPLE 2
[0063] The procedure of Example 1 was repeated, except that the
carbonized pine cone, the sesame oil, the apricot seed extract, the
acorn extract, and the licorice extract were mixed with each other
at a weight ratio of 30:40:10:10:10, respectively.
[0064] The apricot extract was obtained by adding purified water to
a screened raw material, extracting the raw material at about 100 C
for 5 hours, and concentrating the extract to a solid content of
about 75 BRIX at 55 C. According to this method, the acorn extract
and the licorice extract were also obtained.
EXAMPLE 3
[0065] The procedure of Example 2 was repeated, except that the
carbonized pine cone, the sesame oil, the apricot seed extract, the
acorn extract, and the licorice extract were mixed with each other
at a weight ratio of 40:35:5:10:10.
EXAMPLE 4
[0066] The procedure of Example 2 was repeated, except that the
carbonated pine cone, the sesame oil, the apricot seed extract, the
acorn extract, the licorice extract, and a gromwell extract were
mixed with each other at a weight ratio of 30:30:10:10:10:10.
[0067] The gromwell extract was obtained by washing a screened raw
material with purified water, heating sesame oil to a temperature
of 250 C, and adding and concentrating the gromwell in the heated
sesame oil for 3 hours.
EXAMPLE 5
[0068] The procedure of Example 2 was repeated, except that the
carbonated pine cone, the sesame oil, the apricot seed extract, the
acorn extract, the licorice extract, and a pomegranate extract were
mixed with each other at a weight ratio of 30:40:5:5:10:10.
[0069] The pomegranate extract was obtained by adding 15 wt % of a
pomegranate to sesame oil and storing the mixture at a temperature
of 40 C for 20 days.
EXAMPLE 6
[0070] The procedure of Example 2 was repeated, except that the
carbonated pine cone, the sesame oil, the apricot seed extract, the
acorn extract, the licorice extract, and a pasqueflower extract
were mixed with each other at a weight ratio of
40:30:10:5:5:10.
[0071] The pasqueflower extract was prepared by indirectly heating
a pasqueflower at a temperature of 200 C and then adding sesame oil
in an amount of 85 wt % to the carbonized material.
COMPARATIVE EXAMPLE 1
[0072] The procedure of Example 1 was repeated, except that the
sesame oil, the apricot seed extract, the acorn extract, and the
licorice extract were mixed with each other in the same amount.
TEST EXAMPLE 1
Test of Hair Growth Stimulation Effect (Comparison with Comparative
Example)
[0073] On 20 male alopecia patients, each of the hair growth
stimulants prepared in Examples 1 to 6 and Comparative Example 1
was applied on a scalp site that lost hair, 3 times a day, and the
state of hair growth at the applied site was observed. The
observation was performed starting from the start day of the test
at 15-day intervals for 3 months. To evaluate the hair stimulation
effect, the applied site was photographed with a digital camera,
and the ratio (%) of area having recognized hair regeneration
relative to the area of the scalp site that lost hair was
calculated using an image analysis software, and the results are
shown in Table 1 below.
TABLE-US-00001 TABLE 1 (Unit: %) 15 30 45 60 75 90 days days days
days days days Example 1 10 15 20 25 30 50 Example 2 10 20 30 40 60
80 Example 3 10 15 20 25 30 50 Example 4 10 15 30 50 65 75 Example
5 10 20 25 35 60 70 Example 6 10 15 25 45 60 75 Comparative 2 4 8
10 12 12 Example 1
TEST EXAMPLE 2
Test of Hair Growth Stimulation Effect
[0074] In order to examine whether the effect of the inventive hair
growth stimulant is limited only to men and whether the effect is
limited only to a young age group, the inventive hair growth
stimulant was tested for 3 months on each of a first group
consisting of 10 men and 10 women in their latter 30s and a second
group consisting of 10 men and 10 women in their latter 40s.
Specifically, the hair growth stimulation effect was tested in the
same manner as in Test Example 1, except that the hair growth
stimulant prepared in Example 2 was applied thinly on the scalp
daily, the hair was washed in the morning, and the hair was washed
with warm water, and then the hair growth stimulant was applied
evenly on a scalp site that lost hair. The results are shown in
Table 1 for the first group and in Table 3 for the second
group.
[0075] As the clinical volunteers, those who have no experience of
using a minoxidil preparation or various functional products 3
months before the start of the test and who have alopecia diseases,
such as alopecia greata, telogen greata, cicatricial alopecia,
alopecia seborrhecia, alopecia by nutritional deficiency, and
alopecia nervosa, were selected.
TABLE-US-00002 TABLE 2 Hair growth rate of more than 80% (persons)
Hair growth rate of 20-80% (persons) Men 4 1 Women 4 1
TABLE-US-00003 TABLE 3 Hair growth rate of more than 80% (persons)
Hair growth rate of 20-80% (persons) Men 4 1 Women 4 1
TEST EXAMPLE 3
Safety Test
[0076] In the test of hair growth stimulation effect in Test
Example 1, the state of the patient s skin just after applying the
sample was observed and irritability was evaluated based on the
following standards. The results are shown in Table 2.
[0077] ?: no change.
[0078] ?: showed slight erythema on the applied skin site.
[0079] X: showed clear erythema on the applied skin site.
TABLE-US-00004 TABLE 4 Irritability Example 1 ? Example 2 ? Example
3 ? Example 4 ? Example 5 ? Example 6 ? Comparative Example 1 ?
[0080] As can be seen in Table 1, the inventive hair growth
stimulants of Examples 1 to 6 containing the carbonized pine cone
showed an excellent hair growth stimulation effect compared to the
preparation of Comparative Example 1 containing no carbonized pine
cone, and could provide, after 12 weeks of application, a
therapeutic effect of more than 80% on androgenetic alopecia and a
therapeutic effect of more than 90% on alopecia greata. Also, as
can be seen in Tables 2 and 3, the results obtained by testing the
hair growth stimulant prepared in Example 2 on men and women in
their latter 30s and 40s showed that persons having a hair growth
effect of more than 80% exceeded 80% of the whole test subjects,
and the remaining persons all showed a hair growth effect.
[0081] Furthermore, as can be seen in Table 4, all the preparations
of Examples 1 to 6 were not irritable to the skin.
[0082] Accordingly, the inventive hair growth stimulant can be used
as an agent for treating alopecia, and if it is used in other
cosmetic compositions associated with hair, it can provide a
function capable of making hair more glossy and elastic, even upon
use by a general person.
INDUSTRIAL APPLICABILITY
[0083] As described above, the hair growth stimulant according to
the present invention has an excellent hair growth stimulation
effect without causing any side effects or toxicity to the human
body, while it can stimulate hair roots to greatly influence the
growth of hair so as to prevent hair loss and white hair. Also, it
can be provided in the form of creams or ointments having an
excellent effect on hair growth stimulation, and thus considerably
shorten a treatment period. Also, it can keep the anagen-stage hair
by increasing the blood flow of the scalp, and it consists of a
vegetable preparation having excellent effects on hair growth
stimulation for stimulating the regrowth of hair in the telogen
stage and on hair growth, and has no side effects on the human
body. In addition, it can be used through smooth application to a
head, and thus is easy to use.
* * * * *