U.S. patent application number 11/895326 was filed with the patent office on 2008-10-16 for tumor markers in ovarian cancer. Invention is credited to Colleen D. Hough, Patrice J. Morin, Ellen S. Pizer, Cheryl A. Sherman-Baust.
Application Number | 20080253963 11/895326 |
Document ID | / |
Family ID | 22717190 |
Filed Date | 2008-10-16 |
United States Patent Application | 20080253963 |
Kind Code | A1 |
Morin; Patrice J. ; et al. | October 16, 2008 |
The present invention features methods of diagnosing and prognosticating ovarian tumors by detecting increased expression of an ovarian tumor marker gene in a subject or in a sample from a subject. Also featured are kits for the aforementioned diagnostic and prognostic methods. In addition, the invention features methods of treating and preventing ovarian tumors, and methods of inhibiting the growth or metastasis of ovarian tumors, by modulating the production or activity of an ovarian tumor marker polypeptide. Further featured are methods of inhibiting the growth or metastasis of an ovarian tumor by contacting an ovarian tumor cell with an antibody that specifically binds an ovarian tumor marker polypeptide.
Inventors: | Morin; Patrice J.; (Perry Hall, MD) ; Sherman-Baust; Cheryl A.; (Laurel, MD) ; Pizer; Ellen S.; (Bellevue, WA) ; Hough; Colleen D.; (South Jordan, UT) |
Correspondence Address: |
NATIONAL INSTITUTE OF HEALTH;C/O Ballard Spahr Andrews & Ingersoll, LLP SUITE 1000, 999 PEACHTREE STREET ATLANTA GA 30309 US |
Family ID: | 22717190 |
Appl. No.: | 11/895326 |
Filed: | August 24, 2007 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
10257021 | Oct 3, 2002 | 7279294 | ||
PCT/US01/10947 | Apr 3, 2001 | |||
11895326 | ||||
60194336 | Apr 3, 2000 | |||
Current U.S. Class: | 424/1.49 ; 424/138.1; 424/178.1 |
Current CPC Class: | C12Q 1/6809 20130101; C12Q 1/6886 20130101; A61P 35/00 20180101; A61P 35/04 20180101; C12Q 2600/158 20130101 |
Class at Publication: | 424/1.49 ; 424/138.1; 424/178.1 |
International Class: | A61K 51/10 20060101 A61K051/10; A61K 39/395 20060101 A61K039/395; A61P 35/04 20060101 A61P035/04 |
Sequence CWU 1
1
1471490DNAHomo sapiens 1tccttgcccg ccgcagtcgc ctccgccgcg cgcctcctcc
gccgccgcgg actccggcag 60ctttatcgcc agagtccctg aactctcgct ttctttttaa
tcccctgcat cggatcaccg 120gcgtgcccca ccatgtcaga cgcagccgta
gacaccagct ccgaaatcac caccaaggac 180ttaaaggaga agaaggaagt
tgtggaagag gcagaaaatg gaagagacgc ccctgctaac 240gggaatgcta
atgaggaaaa cggggagcag gaggctgaca atgaggtaga cgaagaagag
300gaagaaggtg gggaggaaga ggaggaggaa gaagaaggtg atggtgagga
agaggatgga 360gatgaagatg aggaagctga gtcagctacg ggcaagcggg
cagctgaaga tgatgaggat 420gacgatgtcg ataccaagaa gcagaagacc
gacgaggatg actagacagc aaaaaaggaa 480aagttaaact 4902110PRTHomo
sapiens 2Met Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr
Lys Asp 1 5 10 15Leu Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu
Asn Gly Arg Asp 20 25 30Ala Pro Ala Asn Gly Asn Ala Asn Glu Glu Asn
Gly Glu Gln Glu Ala 35 40 45Asp Asn Glu Val Asp Glu Glu Glu Glu Glu
Gly Gly Glu Glu Glu Glu 50 55 60Glu Glu Glu Glu Gly Asp Gly Glu Glu
Glu Asp Gly Asp Glu Asp Glu65 70 75 80Glu Ala Glu Ser Ala Thr Gly
Lys Arg Ala Ala Glu Asp Asp Glu Asp 85 90 95Asp Asp Val Asp Thr Lys
Lys Gln Lys Thr Asp Glu Asp Asp 100 105 11031093DNAHomo sapiens
3ctgcaaggcg gcggcaggag aggttgtggt gctagtttct ctaagccatc cagtgccatc
60ctcgtcgctg cagcgacacc gctctcgccg ccgccatgac tgagcagatg acccttcgtg
120gcaccctcaa gggccacaac ggctgggtaa cccagatcgc tactaccccg
cagttcccgg 180acatgatcct ctccgcctct cgagataaga ccatcatcat
gtggaaactg accagggatg 240agaccaacta tggaattcca cagcgtgctc
tgcggggtca ctcccacttt gttagtgatg 300tggttatctc ctcagatggc
cagtttgccc tctcaggctc ctgggatgga accctgcgcc 360tctgggatct
cacaacgggc accaccacga ggcgatttgt gggccatacc aaggatgtgc
420tgagtgtggc cttctcctct gacaaccggc agattgtctc tggatctcga
gataaaacca 480tcaagctatg gaataccctg ggtgtgtgca aatacactgt
ccaggatgag agccactcag 540agtgggtgtc ttgtgtccgc ttctcgccca
acagcagcaa ccctatcatc gtctcctgtg 600gctgggacaa gctggtcaag
gtatggaacc tggctaactg caagctgaag accaaccaca 660ttggccacac
aggctatctg aacacggtga ctgtctctcc agatggatcc ctctgtgctt
720ctggaggcaa ggatggccag gccatgttat gggatctcaa cgaaggcaaa
cacctttaca 780cgctagatgg tggggacatc atcaacgccc tgtgcttcag
ccctaaccgc tactggctgt 840gtgctgccac aggccccagc atcaagatct
gggatttaga gggaaagatc attgtagatg 900aactgaagca agaagttatc
agtaccagca gcaaggcaga accaccccag tgcacttccc 960tggcctggtc
tgctgatggc cagactctgt ttgctggcta cacggacaac ctggtgcgag
1020tgtggcaggt gaccattggc acacgctaga agtttatggc agagctttac
aaataaaaaa 1080aaaatggctt ttc 10934317PRTHomo sapiens 4Met Thr Glu
Gln Met Thr Leu Arg Gly Thr Leu Lys Gly His Asn Gly 1 5 10 15Trp
Val Thr Gln Ile Ala Thr Thr Pro Gln Phe Pro Asp Met Ile Leu 20 25
30Ser Ala Ser Arg Asp Lys Thr Ile Ile Met Trp Lys Leu Thr Arg Asp
35 40 45Glu Thr Asn Tyr Gly Ile Pro Gln Arg Ala Leu Arg Gly His Ser
His 50 55 60Phe Val Ser Asp Val Val Ile Ser Ser Asp Gly Gln Phe Ala
Leu Ser65 70 75 80Gly Ser Trp Asp Gly Thr Leu Arg Leu Trp Asp Leu
Thr Thr Gly Thr 85 90 95Thr Thr Arg Arg Phe Val Gly His Thr Lys Asp
Val Leu Ser Val Ala 100 105 110Phe Ser Ser Asp Asn Arg Gln Ile Val
Ser Gly Ser Arg Asp Lys Thr 115 120 125Ile Lys Leu Trp Asn Thr Leu
Gly Val Cys Lys Tyr Thr Val Gln Asp 130 135 140Glu Ser His Ser Glu
Trp Val Ser Cys Val Arg Phe Ser Pro Asn Ser145 150 155 160Ser Asn
Pro Ile Ile Val Ser Cys Gly Trp Asp Lys Leu Val Lys Val 165 170
175Trp Asn Leu Ala Asn Cys Lys Leu Lys Thr Asn His Ile Gly His Thr
180 185 190Gly Tyr Leu Asn Thr Val Thr Val Ser Pro Asp Gly Ser Leu
Cys Ala 195 200 205Ser Gly Gly Lys Asp Gly Gln Ala Met Leu Trp Asp
Leu Asn Glu Gly 210 215 220Lys His Leu Tyr Thr Leu Asp Gly Gly Asp
Ile Ile Asn Ala Leu Cys225 230 235 240Phe Ser Pro Asn Arg Tyr Trp
Leu Cys Ala Ala Thr Gly Pro Ser Ile 245 250 255Lys Ile Trp Asp Leu
Glu Gly Lys Ile Ile Val Asp Glu Leu Lys Gln 260 265 270Glu Val Ile
Ser Thr Ser Ser Lys Ala Glu Pro Pro Gln Cys Thr Ser 275 280 285Leu
Ala Trp Ser Ala Asp Gly Gln Thr Leu Phe Ala Gly Tyr Thr Asp 290 295
300Asn Leu Val Arg Val Trp Gln Val Thr Ile Gly Thr Arg305 310
31552402DNAHomo sapiens 5agtctccgcc gccgccgtga acatggagcc
cccggacgca ccggcccagg cgcgcggggc 60cccgcggctg ctgttgctcg cagtcctgct
ggcggcgcac ccagatgccc aggcggaggt 120gcgcttgtct gtacccccgc
tggtggaggt gatgcgagga aagtctgtca ttctggactg 180cacccctacg
ggaacccacg accattatat gctggaatgg ttccttaccg accgctcggg
240agctcgcccc cgcctagcct cggctgagat gcagggctct gagctccagg
tcacaatgca 300cgacacccgg ggccgcagtc ccccatacca gctggactcc
caggggcgcc tggtgctggc 360tgaggcccag gtgggcgacg agcgagacta
cgtgtgcgtg gtgagggcag gggcggcagg 420cactgctgag gccactgcgc
ggctcaacgt gtttgcaaag ccagaggcca ctgaggtctc 480ccccaacaaa
gggacactgt ctgtgatgga ggactctgcc caggagatcg ccacctgcaa
540cagccggaac gggaacccgg cccccaagat cacgtggtat cgcaacgggc
agcgcctgga 600ggtgcccgta gagatgaacc cagagggcta catgaccagc
cgcacggtcc gggaggcctc 660gggcctgctc tccctcacca gcaccctcta
cctgcggctc cgcaaggatg accgagacgc 720cagcttccac tgcgccgccc
actacagcct gcccgagggc cgccacggcc gcctggacag 780ccccaccttc
cacctcaccc tgcactatcc cacggagcac gtgcagttct gggtgggcag
840cccgtccacc ccagcaggct gggtacgcga gggtgacact gtccagctgc
tctgccgggg 900ggacggcagc cccagcccgg agtatacgct tttccgcctt
caggatgagc aggaggaagt 960gctgaatgtg aatctcgagg ggaacttgac
cctggaggga gtgacccggg gccagagcgg 1020gacctatggc tgcagagtgg
aggattacga cgcggcagat gacgtgcagc tctccaagac 1080gctggagctg
cgcgtggcct atctggaccc cctggagctc agcgagggga aggtgctttc
1140cttacctcta aacagcagtg cagtcgtgaa ctgctccgtg cacggcctgc
ccacccctgc 1200cctacgctgg accaaggact ccactcccct gggcgatggc
cccatgctgt cgctcagttc 1260tatcaccttc gattccaatg gcacctacgt
atgtgaggcc tccctgccca cagtcccggt 1320cctcagccgc acccagaact
tcacgctgct ggtccaaggc tcgccagagc taaagacagc 1380ggaaatagag
cccaaggcag atggcagctg gagggaagga gacgaagtca cactcatctg
1440ctctgcccgc ggccatccag accccaaact cagctggagc caattggggg
gcagccccgc 1500agagccaatc cccggacggc agggttgggt gagcagctct
ctgaccctga aagtgaccag 1560cgccctgagc cgcgatggca tctcctgtga
agcctccaac ccccacggga acaagcgcca 1620tgtcttccac ttcggcgccg
tgagccccca gacctcccag gctggagtgg ccgtcatggc 1680cgtggccgtc
agcgtgggcc tcctgctcct cgtcgttgct gtcttctact gcgtgagacg
1740caaagggggc ccctgctgcc gccagcggcg ggagaagggg gctccgccgc
caggggagcc 1800agggctgagc cactcggggt cggagcaacc agagcagacc
ggccttctca tgggaggtgc 1860ctccggagga gccaggggtg gcagcggggg
cttcggagac gagtgctgag ccaagaacct 1920cctagaggct gtccctggac
ctggagctgc aggcatcaga gaaccagccc tgctcacgcc 1980atgcccgccc
ccgccttccc tcttccctct tccctctccc tgcccagccc tcccttcctt
2040cctctgccgg caaggcaggg acccacagtg gctgcctgcc tccgggaggg
aaggagaggg 2100agggtgggtg ggtgggaggg ggccttcctc cagggaatgt
gactctccca ggccccagaa 2160tagctcctgg acccaagccc aaggcccagc
ctgggacaag gctccgaggg tcggctggcc 2220ggagctattt ttacctcccg
cctcccctgc tggtcccccc acctgacgtc ttgctgcaga 2280gtctgacact
ggattccccc ccctcacccc gcccctggtc ccactcctgc ccccgcccta
2340cctccgcccc accccatcat ctgtggacac tggagtctgg aataaatgct
gtttgtcaca 2400tc 24026628PRTHomo sapiens 6Met Glu Pro Pro Asp Ala
Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 1 5 10 15Leu Leu Leu Ala
Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 20 25 30Val Arg Leu
Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 35 40 45Val Ile
Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 50 55 60Glu
Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser65 70 75
80Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg
85 90 95Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val
Leu 100 105 110Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys
Val Val Arg 115 120 125Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala
Arg Leu Asn Val Phe 130 135 140Ala Lys Pro Glu Ala Thr Glu Val Ser
Pro Asn Lys Gly Thr Leu Ser145 150 155 160Val Met Glu Asp Ser Ala
Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 165 170 175Gly Asn Pro Ala
Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 180 185 190Glu Val
Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 195 200
205Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu
210 215 220Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala
Ala His225 230 235 240Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu
Asp Ser Pro Thr Phe 245 250 255His Leu Thr Leu His Tyr Pro Thr Glu
His Val Gln Phe Trp Val Gly 260 265 270Ser Pro Ser Thr Pro Ala Gly
Trp Val Arg Glu Gly Asp Thr Val Gln 275 280 285Leu Leu Cys Arg Gly
Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 290 295 300Arg Leu Gln
Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly305 310 315
320Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly
325 330 335Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu
Ser Lys 340 345 350Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu
Glu Leu Ser Glu 355 360 365Gly Lys Val Leu Ser Leu Pro Leu Asn Ser
Ser Ala Val Val Asn Cys 370 375 380Ser Val His Gly Leu Pro Thr Pro
Ala Leu Arg Trp Thr Lys Asp Ser385 390 395 400Thr Pro Leu Gly Asp
Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 405 410 415Asp Ser Asn
Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 420 425 430Val
Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 435 440
445Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg
450 455 460Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His
Pro Asp465 470 475 480Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser
Pro Ala Glu Pro Ile 485 490 495Pro Gly Arg Gln Gly Trp Val Ser Ser
Ser Leu Thr Leu Lys Val Thr 500 505 510Ser Ala Leu Ser Arg Asp Gly
Ile Ser Cys Glu Ala Ser Asn Pro His 515 520 525Gly Asn Lys Arg His
Val Phe His Phe Gly Ala Val Ser Pro Gln Thr 530 535 540Ser Gln Ala
Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu545 550 555
560Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly
565 570 575Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro Pro Pro
Gly Glu 580 585 590Pro Gly Leu Ser His Ser Gly Ser Glu Gln Pro Glu
Gln Thr Gly Leu 595 600 605Leu Met Gly Gly Ala Ser Gly Gly Ala Arg
Gly Gly Ser Gly Gly Phe 610 615 620Gly Asp Glu Cys62572780DNAHomo
sapiens 7gtgggcggac cgcgcggctg gaggtgtgag gatccgaacc caggggtggg
gggtggaggc 60ggctcctgcg atcgaagggg acttgagact caccggccgc acgccatgag
ggccctgtgg 120gtgctgggcc tctgctgcgt cctgctgacc ttcgggtcgg
tcagagctga cgatgaagtt 180gatgtggatg gtacagtaga agaggatctg
ggtaaaagta gagaaggatc aaggacggat 240gatgaagtag tacagagaga
ggaagaagct attcagttgg atggattaaa tgcatcacaa 300ataagagaac
ttagagagaa gtcggaaaag tttgccttcc aagccgaagt taacagaatg
360atgaaactta tcatcaattc attgtataaa aataaagaga ttttcctgag
agaactgatt 420tcaaatgctt ctgatgcttt agataagata aggctaatat
cactgactga tgaaaatgct 480ctttctggaa atgaggaact aacagtcaaa
attaagtgtg ataaggagaa gaacctgctg 540catgtcacag acaccggtgt
aggaatgacc agagaagagt tggttaaaaa ccttggtacc 600atagccaaat
ctgggacaag cgagttttta aacaaaatga ctgaagcaca ggaagatggc
660cagtcaactt ctgaattgat tggccagttt ggtgtcggtt tctattccgc
cttccttgta 720gcagataagg ttattgtcac ttcaaaacac aacaacgata
cccagcacat ctgggagtct 780gactccaatg aattttctgt aattgctgac
ccaagaggaa acactctagg acggggaacg 840acaattaccc ttgtcttaaa
agaagaagca tctgattacc ttgaattgga tacaattaaa 900aatctcgtca
aaaaatattc acagttcata aactttccta tttatgtatg gagcagcaag
960actgaaactg ttgaggagcc catggaggaa gaagaagcag ccaaagaaga
gaaagaagaa 1020tctgatgatg aagctgcagt agaggaagaa gaagaagaaa
agaaaccaaa gactaaaaaa 1080gttgaaaaaa ctgtctggga ctgggaactt
atgaatgata tcaaaccaat atggcagaga 1140ccatcaaaag aagtagaaga
agatgaatac aaagctttct acaaatcatt ttcaaaggaa 1200agtgatgacc
ccatggctta tattcacttt actgctgaag gggaagttac cttcaaatca
1260attttatttg tacccacatc tgctccacgt ggtctgtttg acgaatatgg
atctaaaaag 1320agcgattaca ttaagctcta tgtgcgccgt gtattcatca
cagacgactt ccatgatatg 1380atgcctaaat acctcaattt tgtcaagggt
gtggtggact cagatgatct ccccttgaat 1440gtttcccgcg agactcttca
gcaacataaa ctgcttaagg tgattaggaa gaagcttgtt 1500cgtaaaacgc
tggacatgat caagaagatt gctgatgata aatacaatga tactttttgg
1560aaagaatttg gtaccaacat caagcttggt gtgattgaag accactcgaa
tcgaacacgt 1620cttgctaaac ttcttaggtt ccagtcttct catcatccaa
ctgacattac tagcctagac 1680cagtatgtgg aaagaatgaa ggaaaaacaa
gacaaaatct acttcatggc tgggtccagc 1740agaaaagagg ctgaatcttc
tccatttgtt gagcgacttc tgaaaaaggg ctatgaagtt 1800atttacctca
cagaacctgt ggatgaatac tgtattcagg cccttcccga atttgatggg
1860aagaggttcc agaatgttgc caaggaagga gtgaagttcg atgaaagtga
gaaaactaag 1920gagagtcgtg aagcagttga gaaagaattt gagcctctgc
tgaattggat gaaagataaa 1980gcccttaagg acaagattga aaaggctgtg
gtgtctcagc gcctgacaga atctccgtgt 2040gctttggtgg ccagccagta
cggatggtct ggcaacatgg agagaatcat gaaagcacaa 2100gcgtaccaaa
cgggcaagga catctctaca aattactatg cgagtcagaa gaaaacattt
2160gaaattaatc ccagacaccc gctgatcaga gacatgcttc gacgaattaa
ggaagatgaa 2220gatgataaaa cagttttgga tcttgctgtg gttttgtttg
aaacagcaac gcttcggtca 2280gggtatcttt taccagacac taaagcatat
ggagatagaa tagaaagaat gcttcgcctc 2340agtttgaaca ttgaccctga
tgcaaaggtg gaagaagagc ccgaagaaga acctgaagag 2400acagcagaag
acacaacaga agacacagag caagacgaag atgaagaaat ggatgtggga
2460acagatgaag aagaagaaac agcaaaggaa tctacagctg aaaaagatga
attgtaaatt 2520atactctcac catttggatc ctgtgtggag agggaatgtg
aaatttacat catttctttt 2580tgggagagac ttgttttgga tgccccctaa
tccccttctc ccctgcactg taaaatgtgg 2640gattatgggt cacaggaaaa
agtgggtttt ttagttgaat tttttttaac attcctcatg 2700aatgtaaatt
tgtactattt aactgactat tcttgatgta aaatcttgtc atgtgtataa
2760aaataaaaaa gatcccaaat 27808838PRTHomo sapiens 8Val Gly Gly Pro
Arg Gly Trp Arg Cys Glu Asp Pro Asn Pro Gly Val 1 5 10 15Gly Gly
Gly Gly Gly Ser Cys Asp Arg Arg Gly Leu Glu Thr His Arg 20 25 30Pro
His Ala Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu 35 40
45Leu Thr Phe Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly
50 55 60Thr Val Glu Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr
Asp65 70 75 80Asp Glu Val Val Gln Arg Glu Glu Glu Ala Ile Gln Leu
Asp Gly Leu 85 90 95Asn Ala Ser Gln Ile Arg Glu Leu Arg Glu Lys Ser
Glu Lys Phe Ala 100 105 110Phe Gln Ala Glu Val Asn Arg Met Met Lys
Leu Ile Ile Asn Ser Leu 115 120 125Tyr Lys Asn Lys Glu Ile Phe Leu
Arg Glu Leu Ile Ser Asn Ala Ser 130 135 140Asp Ala Leu Asp Lys Ile
Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala145 150 155 160Leu Ser Gly
Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu 165 170 175Lys
Asn Leu Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu 180 185
190Glu Leu Val Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu
195 200 205Phe Leu Asn Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser
Thr Ser 210 215 220Glu Leu Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser
Ala Phe Leu Val225 230 235 240Ala Asp Lys Val Ile Val Thr Ser Lys
His Asn Asn Asp Thr Gln His 245
250 255Ile Trp Glu Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro
Arg 260 265 270Gly Asn Thr Leu Gly Arg Gly Thr Thr Ile Thr Leu Val
Leu Lys Glu 275 280 285Glu Ala Ser Asp Tyr Leu Glu Leu Asp Thr Ile
Lys Asn Leu Val Lys 290 295 300Lys Tyr Ser Gln Phe Ile Asn Phe Pro
Ile Tyr Val Trp Ser Ser Lys305 310 315 320Thr Glu Thr Val Glu Glu
Pro Met Glu Glu Glu Glu Ala Ala Lys Glu 325 330 335Glu Lys Glu Glu
Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu 340 345 350Glu Lys
Lys Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp 355 360
365Glu Leu Met Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu
370 375 380Val Glu Glu Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser
Lys Glu385 390 395 400Ser Asp Asp Pro Met Ala Tyr Ile His Phe Thr
Ala Glu Gly Glu Val 405 410 415Thr Phe Lys Ser Ile Leu Phe Val Pro
Thr Ser Ala Pro Arg Gly Leu 420 425 430Phe Asp Glu Tyr Gly Ser Lys
Lys Ser Asp Tyr Ile Lys Leu Tyr Val 435 440 445Arg Arg Val Phe Ile
Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr 450 455 460Leu Asn Phe
Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn465 470 475
480Val Ser Arg Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg
485 490 495Lys Lys Leu Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile
Ala Asp 500 505 510Asp Lys Tyr Asn Asp Thr Phe Trp Lys Glu Phe Gly
Thr Asn Ile Lys 515 520 525Leu Gly Val Ile Glu Asp His Ser Asn Arg
Thr Arg Leu Ala Lys Leu 530 535 540Leu Arg Phe Gln Ser Ser His His
Pro Thr Asp Ile Thr Ser Leu Asp545 550 555 560Gln Tyr Val Glu Arg
Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met 565 570 575Ala Gly Ser
Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg 580 585 590Leu
Leu Lys Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp 595 600
605Glu Tyr Cys Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln
610 615 620Asn Val Ala Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys
Thr Lys625 630 635 640Glu Ser Arg Glu Ala Val Glu Lys Glu Phe Glu
Pro Leu Leu Asn Trp 645 650 655Met Lys Asp Lys Ala Leu Lys Asp Lys
Ile Glu Lys Ala Val Val Ser 660 665 670Gln Arg Leu Thr Glu Ser Pro
Cys Ala Leu Val Ala Ser Gln Tyr Gly 675 680 685Trp Ser Gly Asn Met
Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr 690 695 700Gly Lys Asp
Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe705 710 715
720Glu Ile Asn Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile
725 730 735Lys Glu Asp Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val
Val Leu 740 745 750Phe Glu Thr Ala Thr Leu Arg Ser Gly Tyr Leu Leu
Pro Asp Thr Lys 755 760 765Ala Tyr Gly Asp Arg Ile Glu Arg Met Leu
Arg Leu Ser Leu Asn Ile 770 775 780Asp Pro Asp Ala Lys Val Glu Glu
Glu Pro Glu Glu Glu Pro Glu Glu785 790 795 800Thr Ala Glu Asp Thr
Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu 805 810 815Met Asp Val
Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr 820 825 830Ala
Glu Lys Asp Glu Leu 83592912DNAHomo sapiens 9cagttgcttc agcgtcccgg
tgtggctgtg ccgttggtcc tgtgcggtca cttagccaag 60atgcctgagg aaacccagac
ccaagaccaa ccgatggagg aggaggaggt tgagacgttc 120gcctttcagg
cagaaattgc ccagttgatg tcattgatca tcaatacttt ctactcgaac
180aaagagatct ttctgagaga gctcatttca aattcatcag atgcattgga
caaaatccgg 240tatgaaactt tgacagatcc cagtaaatta gactctggga
aagagctgca tattaacctt 300ataccgaaca aacaagatcg aactctcact
attgtggata ctggaattgg aatgaccaag 360gctgacttga tcaataacct
tggtactatc gccaagtctg ggaccaaagc gttcatggaa 420gctttgcagg
ctggtgcaga tatctctatg attggccagt tcggtgttgg tttttattct
480gcttatttgg ttgctgagaa agtaactgtg atcaccaaac ataacgatga
tgagcagtac 540gcttgggagt cctcagcagg gggatcattc acagtgagga
cagacacagg tgaacctatg 600ggtcgtggaa caaaagttat cctacacctg
aaagaagacc aaactgagta cttggaggaa 660cgaagaataa aggagattgt
gaagaaacat tctcagttta ttggatatcc cattactctt 720tttgtggaga
aggaacgtga taaagaagta agcgatgatg aggctgaaga aaaggaagac
780aaagaagaag aaaaagaaaa agaagagaaa gagtcggaag acaaacctga
aattgaagat 840gttggttctg atgaggaaga agaaaagaag gatggtgaca
agaagaagaa gaagaagatt 900aaggaaaagt acatcgatca agaagagctc
aacaaaacaa agcccatctg gaccagaaat 960cccgacgata ttactaatga
ggagtacgga gaattctata agagcttgac caatgactgg 1020gaagatcact
tggcagtgaa gcatttttca gttgaaggac agttggaatt cagagccctt
1080ctatttgtcc cacgacgtgc tccttttgat ctgtttgaaa acagaaagaa
aaagaacaat 1140atcaaattgt atgtacgcag agttttcatc atggataact
gtgaggagct aatccctgaa 1200tatctgaact tcattagagg ggtggtagac
tcggaggatc tccctctaaa catatcccgt 1260gagatgttgc aacaaagcaa
aattttgaaa gttatcagga agaatttggt caaaaaatgc 1320ttagaactct
ttactgaact ggcggaagat aaagagaact acaagaaatt ctatgagcag
1380ttctctaaaa acataaagct tggaatacac gaagactctc aaaatcggaa
gaagctttca 1440gagctgttaa ggtactacac atctgcctct ggtgatgaga
tggtttctct caaggactac 1500tgcaccagaa tgaaggagaa ccagaaacat
atctattata tcacaggtga gaccaaggac 1560caggtagcta actcagcctt
tgtggaacgt cttcggaaac atggcttaga agtgatctat 1620atgattgagc
ccattgatga gtactgtgtc caacagctga aggaatttga ggggaagact
1680ttagtgtcag tcaccaaaga aggcctggaa cttccagagg atgaagaaga
gaaaaagaag 1740caggaagaga aaaaaacaaa gtttgagaac ctctgcaaaa
tcatgaaaga catattggag 1800aaaaaagttg aaaaggtggt tgtgtcaaac
cgattggtga catctccatg ctgtattgtc 1860acaagcacat atggctggac
agcaaacatg gagagaatca tgaaagctca agccctaaga 1920gacaactcaa
caatgggtta catggcagca aagaaacacc tggagataaa ccctgaccat
1980tccattattg agaccttaag gcaaaaggca gaggctgata agaacgacaa
gtctgtgaag 2040gatctggtca tcttgcttta tgaaactgcg ctcctgtctt
ctggcttcag tctggaagat 2100ccccagacac atgctaacag gatctacagg
atgatcaaac ttggtctggg tattgatgaa 2160gatgacccta ctgctgatga
taccagtgct gctgtaactg aagaaatgcc accccttgaa 2220ggagatgacg
acacatcacg catggaagaa gtagactaat ctctggctga gggatgactt
2280acctgttcag tactctacaa ttcctctgat aatatatttt caaggatgtt
tttctttatt 2340tttgttaata ttaaaaagtc tgtatggcat gacaactact
ttaaggggaa gataagattt 2400ctgtctacta agtgatgctg tgatacctta
ggcactaaag cagagctagt aatgcttttt 2460gagtttcatg ttggttcttt
cacagatggg gtaacgtgca ctgtaagacg tatgtaacat 2520gatgttaact
ttgtgtggtc taaagtgttt agctgtcaag ccggatgcct aagtagacca
2580aatcttgtta ttgaagtgtt ctgagctgta tcttgatgtt tagaaaagta
ttcgttacat 2640cttgtaggat ctactttttg aacttttcat tccctgtagt
tgacaattct gcatgtacta 2700gtcctctaga aataggttaa actgaagcaa
cttgatggaa ggatctctcc acagggcttg 2760ttttccaaag aaaagtattg
tttggaggag caaagttaaa agcctaccta agcatatcgt 2820aaagctgttc
aaatactcga gcccagtctt gtggatggaa atgtagtgct cgagtcacat
2880tctgcttaaa gttgtaacaa atacagatga gt 291210732PRTHomo sapiens
10Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu 1
5 10 15Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser
Leu 20 25 30Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg
Glu Leu 35 40 45Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr
Glu Thr Leu 50 55 60Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu
His Ile Asn Leu65 70 75 80Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr
Ile Val Asp Thr Gly Ile 85 90 95Gly Met Thr Lys Ala Asp Leu Ile Asn
Asn Leu Gly Thr Ile Ala Lys 100 105 110Ser Gly Thr Lys Ala Phe Met
Glu Ala Leu Gln Ala Gly Ala Asp Ile 115 120 125Ser Met Ile Gly Gln
Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val 130 135 140Ala Glu Lys
Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr145 150 155
160Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr
165 170 175Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu
Lys Glu 180 185 190Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys
Glu Ile Val Lys 195 200 205Lys His Ser Gln Phe Ile Gly Tyr Pro Ile
Thr Leu Phe Val Glu Lys 210 215 220Glu Arg Asp Lys Glu Val Ser Asp
Asp Glu Ala Glu Glu Lys Glu Asp225 230 235 240Lys Glu Glu Glu Lys
Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro 245 250 255Glu Ile Glu
Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly 260 265 270Asp
Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu 275 280
285Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile
290 295 300Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn
Asp Trp305 310 315 320Glu Asp His Leu Ala Val Lys His Phe Ser Val
Glu Gly Gln Leu Glu 325 330 335Phe Arg Ala Leu Leu Phe Val Pro Arg
Arg Ala Pro Phe Asp Leu Phe 340 345 350Glu Asn Arg Lys Lys Lys Asn
Asn Ile Lys Leu Tyr Val Arg Arg Val 355 360 365Phe Ile Met Asp Asn
Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe 370 375 380Ile Arg Gly
Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg385 390 395
400Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu
405 410 415Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp
Lys Glu 420 425 430Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn
Ile Lys Leu Gly 435 440 445Ile His Glu Asp Ser Gln Asn Arg Lys Lys
Leu Ser Glu Leu Leu Arg 450 455 460Tyr Tyr Thr Ser Ala Ser Gly Asp
Glu Met Val Ser Leu Lys Asp Tyr465 470 475 480Cys Thr Arg Met Lys
Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly 485 490 495Glu Thr Lys
Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg 500 505 510Lys
His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr 515 520
525Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val
530 535 540Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys
Lys Lys545 550 555 560Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu
Cys Lys Ile Met Lys 565 570 575Asp Ile Leu Glu Lys Lys Val Glu Lys
Val Val Val Ser Asn Arg Leu 580 585 590Val Thr Ser Pro Cys Cys Ile
Val Thr Ser Thr Tyr Gly Trp Thr Ala 595 600 605Asn Met Glu Arg Ile
Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr 610 615 620Met Gly Tyr
Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His625 630 635
640Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp
645 650 655Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala
Leu Leu 660 665 670Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His
Ala Asn Arg Ile 675 680 685Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile
Asp Glu Asp Asp Pro Thr 690 695 700Ala Asp Asp Thr Ser Ala Ala Val
Thr Glu Glu Met Pro Pro Leu Glu705 710 715 720Gly Asp Asp Asp Thr
Ser Arg Met Glu Glu Val Asp 725 730112227DNAHomo sapiens
11gacgacctgt ctcgccgagc gcacgcttgc cgccgccccg cagaaatgct tcggttaccc
60acagtctttc gccagatgag accggtgtcc agggtactgg ctcctcatct cactcgggct
120tatgccaaag atgtaaaatt tggtgcagat gcccgagcct taatgcttca
aggtgtagac 180cttttagccg atgctgtggc cgttacaatg gggccaaagg
gaagaacagt gattattgag 240cagagttggg gaagtcccaa agtaacaaaa
gatggtgtga ctgttgcaaa gtcaattgac 300ttaaaagata aatacaagaa
cattggagct aaacttgttc aagatgttgc caataacaca 360aatgaagaag
ctggggatgg cactaccact gctactgtac tggcacgctc tatagccaag
420gaaggcttcg agaagattag caaaggtgct aatccagtgg aaatcaggag
aggtgtgatg 480ttagctgttg atgctgtaat tgctgaactt aaaaagcagt
ctaaacctgt gaccacccct 540gaagaaattg cacaggttgc tacgatttct
gcaaacggag acaaagaaat tggcaatatc 600atctctgatg caatgaaaaa
agttggaaga aagggtgtca tcacagtaaa ggatggaaaa 660acactgaatg
atgaattaga aattattgaa ggcatgaagt ttgatcgagg ctatatttct
720ccatacttta ttaatacatc aaaaggtcag aaatgtgaat tccaggatgc
ctatgttctg 780ttgagtgaaa agaaaatttc tagtatccag tccattgtac
ctgctcttga aattgccaat 840gctcaccgta agcctttggt cataatcgct
gaagatgttg atggagaagc tctaagtaca 900ctcgtcttga ataggctaaa
ggttggtctt caggttgtgg cagtcaaggc tccagggttt 960ggtgacaata
gaaagaacca gcttaaagat atggctattg ctactggtgg tgcagtgttt
1020ggagaagagg gattgaccct gaatcttgaa gacgttcagc ctcatgactt
aggaaaagtt 1080ggagaggtca ttgtgaccaa agacgatgcc atgctcttaa
aaggaaaagg tgacaaggct 1140caaattgaaa aacgtattca agaaatcatt
gagcagttag atgtcacaac tagtgaatat 1200gaaaaggaaa aactgaatga
acggcttgca aaactttcag atggagtggc tgtgctgaag 1260gttggtggga
caagtgatgt tgaagtgaat gaaaagaaag acagagttac agatgccctt
1320aatgctacaa gagctgctgt tgaagaaggc attgttttgg gagggggttg
tgccctcctt 1380cgatgcattc cagccttgga ctcattgact ccagctaatg
aagatcaaaa aattggtata 1440gaaattatta aaagaacact caaaattcca
gcaatgacca ttgctaagaa tgcaggtgtt 1500gaaggatctt tgatagttga
gaaaattatg caaagttcct cagaagttgg ttatgatgct 1560atggctggag
attttgtgaa tatggtggaa aaaggaatca ttgacccaac aaaggttgtg
1620agaactgctt tattggatgc tgctggtgtg gcctctctgt taactacagc
agaagttgta 1680gtcacagaaa ttcctaaaga agagaaggac cctggaatgg
gtgcaatggg tggaatggga 1740ggtggtatgg gaggtggcat gttctaactc
ctagactagt gctttacctt tattaatgaa 1800ctgtgacagg aagcccaagg
cagtgttcct caccaataac ttcagagaag tcagttggag 1860aaaatgaaga
aaaaggctgg ctgaaaatca ctataaccat cagttactgg tttcagttga
1920caaaatatat aatggtttac tgctgtcatt gtccatgcct acagataatt
tattttgtat 1980ttttgaataa aaaacatttg tacattcctg atactgggta
caagagccat gtaccagtgt 2040actgctttca acttaaatca ctgaggcatt
tttactacta ttctgttaaa atcaggattt 2100tagtgcttgc caccaccaga
tgagaagtta agcagccttt ctgtggagag tgagaataat 2160tgtgtacaaa
gtagagaagt atccaattat gtgacaacct ttgtgtaata aaaatttgtt 2220taaagtt
222712573PRTHomo sapiens 12Met Leu Arg Leu Pro Thr Val Phe Arg Gln
Met Arg Pro Val Ser Arg 1 5 10 15Val Leu Ala Pro His Leu Thr Arg
Ala Tyr Ala Lys Asp Val Lys Phe 20 25 30Gly Ala Asp Ala Arg Ala Leu
Met Leu Gln Gly Val Asp Leu Leu Ala 35 40 45Asp Ala Val Ala Val Thr
Met Gly Pro Lys Gly Arg Thr Val Ile Ile 50 55 60Glu Gln Ser Trp Gly
Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val65 70 75 80Ala Lys Ser
Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 85 90 95Leu Val
Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 100 105
110Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe
115 120 125Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg
Gly Val 130 135 140Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys
Lys Gln Ser Lys145 150 155 160Pro Val Thr Thr Pro Glu Glu Ile Ala
Gln Val Ala Thr Ile Ser Ala 165 170 175Asn Gly Asp Lys Glu Ile Gly
Asn Ile Ile Ser Asp Ala Met Lys Lys 180 185 190Val Gly Arg Lys Gly
Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 195 200 205Asp Glu Leu
Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 210 215 220Ser
Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln225 230
235 240Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln
Ser 245 250 255Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys
Pro Leu Val 260 265 270Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu
Ser Thr Leu Val Leu 275 280 285Asn Arg
Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 290 295
300Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala
Thr305 310 315 320Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu
Asn Leu Glu Asp 325 330 335Val Gln Pro His Asp Leu Gly Lys Val Gly
Glu Val Ile Val Thr Lys 340 345 350Asp Asp Ala Met Leu Leu Lys Gly
Lys Gly Asp Lys Ala Gln Ile Glu 355 360 365Lys Arg Ile Gln Glu Ile
Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 370 375 380Tyr Glu Lys Glu
Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly385 390 395 400Val
Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 405 410
415Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val
420 425 430Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg
Cys Ile 435 440 445Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp
Gln Lys Ile Gly 450 455 460Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile
Pro Ala Met Thr Ile Ala465 470 475 480Lys Asn Ala Gly Val Glu Gly
Ser Leu Ile Val Glu Lys Ile Met Gln 485 490 495Ser Ser Ser Glu Val
Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 500 505 510Met Val Glu
Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 515 520 525Leu
Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 530 535
540Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly
Ala545 550 555 560Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met
Phe 565 570132376DNAHomo sapiens 13gaggaggagt ggggaccggg cggggggtgg
aggaagaggc ctcgcgcaga ggagggagca 60attgaatttc aaacacaaac aactcgacga
gcgcgcaccc accgcgccgg agccttgccc 120cgatccgcgc ccgccccgtc
cgtgcggcgc gcgggcggag acgccgtggc cgcgccggag 180ctcgggccgg
gggccaccat cgaggcgggg gccgcgcgag ggccggagcg gagcggcgcc
240gccaccgccg cacgcgcaaa cttgggctcg cgcttcccgg cccggcgcgg
agcccggggc 300gcccggagcc ccgccatgtc gcgatccaac cggcagaagg
agtacaaatg cggggacctg 360gtgttcgcca agatgaaggg ctacccacac
tggccggccc ggattgacga gatgcctgag 420gctgccgtga aatcaacagc
caacaaatac caagtctttt ttttcgggac ccacgagacg 480gcattcctgg
gccccaaaga cctcttccct tacgaggaat ccaaggagaa gtttggcaag
540cccaacaaga ggaaagggtt cagcgagggg ctgtgggaga tcgagaacaa
ccctactgtc 600aaggcttccg gctatcagtc ctcccagaaa aagagctgtg
tggaagagcc tgaaccagag 660cccgaagctg cagagggtga cggtgataag
aaggggaatg cagagggcag cagcgacgag 720gaagggaagc tggtcattga
tgagccagcc aaggagaaga acgagaaagg agcgttgaag 780aggagagcag
gggacttgct ggaggactct cctaaacgtc ccaaggaggc agaaaaccct
840gaaggagagg agaaggaggc agccaccttg gaggttgaga ggccccttcc
tatggaggtg 900gaaaagaata gcaccccctc tgagcccggc tctggccggg
ggcctcccca agaggaagaa 960gaagaggagg atgaagagga agaggctacc
aaggaagatg ctgaggcccc aggcatcaga 1020gatcatgaga gcctgtagcc
accaatgttt caagaggagc ccccaccctg ttcctgctgc 1080tgtctgggtg
ctactgggga aactggccat ggcctgcaaa ctgggaaccc ctttcccacc
1140ccaacctgct ctcctcttct actcactttt cccactccaa gcccagccca
tggagattga 1200cctggatggg gcaggccacc tggctctcac ctctaggtcc
ccatactcct atgatctgag 1260tcagagccat gtcttctccc tggaatgagt
tgaggccact gtgttccttc cgcttggagc 1320tattttccag gcttctgctg
gggcctggga caactgctcc cacctcctga cacccttctc 1380ccactctcct
aggcattctg gacctctggg ttgggatcag gggtaggaat ggaaggatgg
1440agcatcaaca gcagggtggg cttgtggggc ctgggagggg caatcctcaa
atgcggggtg 1500ggggcagcac aggagggcgg cctccttctg agctcctgtc
ccctgctaca cctattatcc 1560cagctgccta gattcaggga aagtgggaca
gcttgtaggg gaggggctcc tttccataaa 1620tccttgatga ttgacaacac
ccatttttcc ttttgccgac cccaagagtt ttgggagttg 1680tagttaatca
tcaagagaat ttggggcttc caagttgttc gggccaagga cctgagacct
1740gaagggttga ctttacccat ttgggtggga gtgttgagca tctgtccccc
tttagatctc 1800tgaagccaca aataggatgc ttgggaagac tcctagctgt
cctttttcct ctccacacag 1860tgctcaaggc cagcttatag tcatatatat
cacccagaca taaaggaaaa gacacatttt 1920ttaggaaatg tttttaataa
aagaaaatta caaaaaaaaa ttttaaagac ccctaaccct 1980ttgtgtgctc
tccattctgc tccttcccca tcgttgcccc catttctgag gtgcactggg
2040aggctcccct tctatttggg gcttgatgac tttctttttg tagctggggc
tttgatgttc 2100cttccagtgt catttctcat ccacataccc tgacctggcc
ccctcagtgt tgtcaccaga 2160tctgatttgt aacccactga gaggacagag
agaaataagt gccctctccc accctcttcc 2220tactggtctc tctatgcctc
tctacagtct cgtctctttt accctggccc ctctcccttg 2280ggctctgatg
aaaaattgct gactgtagct ttggaagttt agctctgaga accgtagatg
2340atttcagttc taggaaaata aaacccgttg attact 237614240PRTHomo
sapiens 14Met Ser Arg Ser Asn Arg Gln Lys Glu Tyr Lys Cys Gly Asp
Leu Val 1 5 10 15Phe Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala
Arg Ile Asp Glu 20 25 30Met Pro Glu Ala Ala Val Lys Ser Thr Ala Asn
Lys Tyr Gln Val Phe 35 40 45Phe Phe Gly Thr His Glu Thr Ala Phe Leu
Gly Pro Lys Asp Leu Phe 50 55 60Pro Tyr Glu Glu Ser Lys Glu Lys Phe
Gly Lys Pro Asn Lys Arg Lys65 70 75 80Gly Phe Ser Glu Gly Leu Trp
Glu Ile Glu Asn Asn Pro Thr Val Lys 85 90 95Ala Ser Gly Tyr Gln Ser
Ser Gln Lys Lys Ser Cys Val Glu Glu Pro 100 105 110Glu Pro Glu Pro
Glu Ala Ala Glu Gly Asp Gly Asp Lys Lys Gly Asn 115 120 125Ala Glu
Gly Ser Ser Asp Glu Glu Gly Lys Leu Val Ile Asp Glu Pro 130 135
140Ala Lys Glu Lys Asn Glu Lys Gly Ala Leu Lys Arg Arg Ala Gly
Asp145 150 155 160Leu Leu Glu Asp Ser Pro Lys Arg Pro Lys Glu Ala
Glu Asn Pro Glu 165 170 175Gly Glu Glu Lys Glu Ala Ala Thr Leu Glu
Val Glu Arg Pro Leu Pro 180 185 190Met Glu Val Glu Lys Asn Ser Thr
Pro Ser Glu Pro Gly Ser Gly Arg 195 200 205Gly Pro Pro Gln Glu Glu
Glu Glu Glu Glu Asp Glu Glu Glu Glu Ala 210 215 220Thr Lys Glu Asp
Ala Glu Ala Pro Gly Ile Arg Asp His Glu Ser Leu225 230 235
240153689DNAHomo sapiens 15aagatctcat aaaatctatg ctgaggaatg
agcgacagtt caaggaggag aagcttgcag 60agcagctcaa gcaagctgag gagctcaggc
aatataaagt cctggttcac gctcaggaac 120gagagctgac ccagttaagg
gagaagttgc gggaagggag agatgcctcc cgctcattga 180atgagcatct
ccaggccctc ctcactccgg atgagccgga caagtcccag gggcaggacc
240tccaagaaca gctggctgag gggtgtagac tggcacagca ccttgtccaa
aagctcagcc 300cagaaaatga caacgatgac gatgaagatg ttcaagttga
ggtggctgag aaagtgcaga 360aatcgtctgc ccccagggag atgcagaagg
ctgaagaaaa ggaagtccct gaggactcac 420tggaggaatg tgccatcact
tgttcaaata gccatggccc ttatgactcc aaccagccac 480ataggaaaac
caaaatcaca tttgaggaag acaaagtcga ctcaactctc attggctcat
540cctctcatgt tgaatgggag gatgctgtac acattattcc agaaaatgaa
agtgatgatg 600aggaagagga agaaaaagga ccagtgtctc ccaggaatct
gcaggagtct gaagaggagg 660aagtccccca ggagtcctgg gatgaaggtt
attcgactct ctcaattcct cctgaaatgt 720tggcctcgta caagtcttac
agcagcacat ttcactcatt agaggaacag caagtctgca 780tggctgttga
cataggcaga catcggtggg atcaagtgaa aaaggaggac cacgaggcaa
840caggtcccag gctcagcaga gagctgctgg atgagaaagg gcctgaagtc
ttgcaggact 900cactggatag atgttattca actccttcag gttgtcttga
actgactgac tcatgccagc 960cctacagaag tgccttttac gtattggagc
aacagcgtgt tggcttggct gttaacatgg 1020atgaaattga aaagtaccaa
gaagtggaag aagaccaaga cccatcatgc cccaggctca 1080gcagggagct
gctggatgag aaagagcctg aagtcttgca ggactcactg ggtagatgtt
1140attcgactcc ttcaggttat cttgaactgc ctgacttagg ccagccctac
agcagtgctg 1200tttactcatt ggaggaacag taccttggct tggctcttga
cgtggacaga attaaaaagg 1260accaagaaga ggaagaagac caaggcccac
catgccccag gctcagcagg gagctgctgg 1320aggtagtaga gcctgaagtc
ttgcaggact cactggatag atgttattca actccttcca 1380gttgtcttga
acagcctgac tcctgccagc cctatggaag ttccttttat gcattggagg
1440aaaagcatgt tggcttttct cttgacgtgg gagaaattga aaagaagggg
aaggggaaga 1500aaagaagggg aagaagatca aagaaggaaa gaagaagggg
aagaaaagaa ggggaagaag 1560atcaaaaccc accatgcccc aggctcagca
gggagctgct ggatgagaaa gggcctgaag 1620tcttgcagga ctcactggat
agatgttatt caactccttc aggttgtctt gaactgactg 1680actcatgcca
gccctacaga agtgcctttt acatattgga gcaacagcgt gttggcttgg
1740ctgttgacat ggatgaaatt gaaaagtacc aagaagtgga agaagaccaa
gacccatcat 1800gccccaggct cagcggggag ctgttggatg agaaagagcc
tgaagtcttg caggagtcac 1860tggatagatg ctattcaact ccttcaggtt
gtcttgaact gactgactca tgccagccct 1920acagaagtgc cttttacata
ttggagcaac agcgtgttgg cttggctgtt gacatggatg 1980aaattgaaaa
gtaccaagaa gtggaagaag accaagaccc atcatgcccc aggctcagca
2040gggagctgct ggatgagaaa gagcctgaag tcttgcagga ctcactgggt
agatgttatt 2100cgactccttc aggttatctt gaactgcctg acttaggcca
gccctacagc agtgctgttt 2160actcattgga ggaacagtac cttggcttgg
ctcttgacgt ggacagaatt aaaaaggacc 2220aagaagagga agaagaccaa
ggcccaccat gccccaggct cagcagggag ctgctggagg 2280tagtagagcc
tgaagtcttg caggactcac tggatagatg ttattcaact ccttccagtt
2340gtcttgaaca gcctgactcc tgccagccct atggaagttc cttttatgca
ttggaggaaa 2400aacatgttgg cttttctctt gacgtgggag aaattgaaaa
gaaggggaag gggaagaaaa 2460gaaggggaag aagatcaaag aaggaaagaa
gaaggggaag aaaagaaggg gaagaagatc 2520aaaacccacc atgccccagg
ctcaacagca tgctgatgga agtggaagag cctgaagtct 2580tgcaggactc
actggatata tgttattcga ctccgtcaat gtactttgaa ctacctgact
2640cattccagca ctacagaagt gtgttttact catttgagga agagcatatc
agcttcgccc 2700tttacgtgga caataggttt tttactttga cggtgacaag
tctccacctg gtgttccaga 2760tgggagtcat attcccacaa taagcagccc
ttactaagcc gagaggtgtc attcctgcag 2820gcaggaccta taggcacgtg
aagatttgaa tgaaagtaca gttccatttg gaagcccaga 2880cataggatgg
gtcagtgggc atggctctat tcctattctc aaaccatgcc agtggcaacc
2940tgtgctcagt ctgaagacaa tggacccacg ttaggtgtga cacgttcaca
taactgtgca 3000gcacatgccg ggagtgatca gtcagacatt ttaatttgaa
ccacgtatct ctgggtagct 3060acaaaattcc tcagggatgt cattttgcag
gcatgtctct gagcttctat acctgctcaa 3120ggtcattgtc atctttgtgt
ttagctcatc caaaggtgtt accctggttt caatgaacct 3180aacctcattc
tttgtgtctt cagtgttggc ttgttttagc tgatccatct gtaacacagg
3240agggatcctt ggctgaggat tgtatttcag aaccaccaac tgctcttgac
aattgttaac 3300ccgctaggct cctttggtta gagaagccac agtccttcag
cctccaattg gtgtcagtac 3360ttaggaagac cacagctaga tggacaaaca
gcattgggag gccttagccc tgctcctctc 3420aattccatcc tgtagagaac
aggagtcagg agccgctggc aggagacagc atgtcaccca 3480ggactctgcc
ggtgcagaat atgagcaatg ccatgttctt gcagaaaacg cttaacctga
3540gtttcatagg aggtaatcac cagacaactg cagaatgtag aacactgagc
aggacaactg 3600acctgtctcc ttcacatagt ccatatcacc acaaatcaca
caacaaaaag gagaagagat 3660attttcggtt gaaaaaaagt aaaaagata
368916921PRTHomo sapiens 16Met Leu Arg Asn Glu Arg Gln Phe Lys Glu
Glu Lys Leu Ala Glu Gln 1 5 10 15Leu Lys Gln Ala Glu Glu Leu Arg
Gln Tyr Lys Val Leu Val His Ala 20 25 30Gln Glu Arg Glu Leu Thr Gln
Leu Arg Glu Lys Leu Arg Glu Gly Arg 35 40 45Asp Ala Ser Arg Ser Leu
Asn Glu His Leu Gln Ala Leu Leu Thr Pro 50 55 60Asp Glu Pro Asp Lys
Ser Gln Gly Gln Asp Leu Gln Glu Gln Leu Ala65 70 75 80Glu Gly Cys
Arg Leu Ala Gln His Leu Val Gln Lys Leu Ser Pro Glu 85 90 95Asn Asp
Asn Asp Asp Asp Glu Asp Val Gln Val Glu Val Ala Glu Lys 100 105
110Val Gln Lys Ser Ser Ala Pro Arg Glu Met Gln Lys Ala Glu Glu Lys
115 120 125Glu Val Pro Glu Asp Ser Leu Glu Glu Cys Ala Ile Thr Cys
Ser Asn 130 135 140Ser His Gly Pro Tyr Asp Ser Asn Gln Pro His Arg
Lys Thr Lys Ile145 150 155 160Thr Phe Glu Glu Asp Lys Val Asp Ser
Thr Leu Ile Gly Ser Ser Ser 165 170 175His Val Glu Trp Glu Asp Ala
Val His Ile Ile Pro Glu Asn Glu Ser 180 185 190Asp Asp Glu Glu Glu
Glu Glu Lys Gly Pro Val Ser Pro Arg Asn Leu 195 200 205Gln Glu Ser
Glu Glu Glu Glu Val Pro Gln Glu Ser Trp Asp Glu Gly 210 215 220Tyr
Ser Thr Leu Ser Ile Pro Pro Glu Met Leu Ala Ser Tyr Lys Ser225 230
235 240Tyr Ser Ser Thr Phe His Ser Leu Glu Glu Gln Gln Val Cys Met
Ala 245 250 255Val Asp Ile Gly Arg His Arg Trp Asp Gln Val Lys Lys
Glu Asp His 260 265 270Glu Ala Thr Gly Pro Arg Leu Ser Arg Glu Leu
Leu Asp Glu Lys Gly 275 280 285Pro Glu Val Leu Gln Asp Ser Leu Asp
Arg Cys Tyr Ser Thr Pro Ser 290 295 300Gly Cys Leu Glu Leu Thr Asp
Ser Cys Gln Pro Tyr Arg Ser Ala Phe305 310 315 320Tyr Val Leu Glu
Gln Gln Arg Val Gly Leu Ala Val Asn Met Asp Glu 325 330 335Ile Glu
Lys Tyr Gln Glu Val Glu Glu Asp Gln Asp Pro Ser Cys Pro 340 345
350Arg Leu Ser Arg Glu Leu Leu Asp Glu Lys Glu Pro Glu Val Leu Gln
355 360 365Asp Ser Leu Gly Arg Cys Tyr Ser Thr Pro Ser Gly Tyr Leu
Glu Leu 370 375 380Pro Asp Leu Gly Gln Pro Tyr Ser Ser Ala Val Tyr
Ser Leu Glu Glu385 390 395 400Gln Tyr Leu Gly Leu Ala Leu Asp Val
Asp Arg Ile Lys Lys Asp Gln 405 410 415Glu Glu Glu Glu Asp Gln Gly
Pro Pro Cys Pro Arg Leu Ser Arg Glu 420 425 430Leu Leu Glu Val Val
Glu Pro Glu Val Leu Gln Asp Ser Leu Asp Arg 435 440 445Cys Tyr Ser
Thr Pro Ser Ser Cys Leu Glu Gln Pro Asp Ser Cys Gln 450 455 460Pro
Tyr Gly Ser Ser Phe Tyr Ala Leu Glu Glu Lys His Val Gly Phe465 470
475 480Ser Leu Asp Val Gly Glu Ile Glu Lys Lys Gly Lys Gly Lys Lys
Arg 485 490 495Arg Gly Arg Arg Ser Lys Lys Glu Arg Arg Arg Gly Arg
Lys Glu Gly 500 505 510Glu Glu Asp Gln Asn Pro Pro Cys Pro Arg Leu
Ser Arg Glu Leu Leu 515 520 525Asp Glu Lys Gly Pro Glu Val Leu Gln
Asp Ser Leu Asp Arg Cys Tyr 530 535 540Ser Thr Pro Ser Gly Cys Leu
Glu Leu Thr Asp Ser Cys Gln Pro Tyr545 550 555 560Arg Ser Ala Phe
Tyr Ile Leu Glu Gln Gln Arg Val Gly Leu Ala Val 565 570 575Asp Met
Asp Glu Ile Glu Lys Tyr Gln Glu Val Glu Glu Asp Gln Asp 580 585
590Pro Ser Cys Pro Arg Leu Ser Gly Glu Leu Leu Asp Glu Lys Glu Pro
595 600 605Glu Val Leu Gln Glu Ser Leu Asp Arg Cys Tyr Ser Thr Pro
Ser Gly 610 615 620Cys Leu Glu Leu Thr Asp Ser Cys Gln Pro Tyr Arg
Ser Ala Phe Tyr625 630 635 640Ile Leu Glu Gln Gln Arg Val Gly Leu
Ala Val Asp Met Asp Glu Ile 645 650 655Glu Lys Tyr Gln Glu Val Glu
Glu Asp Gln Asp Pro Ser Cys Pro Arg 660 665 670Leu Ser Arg Glu Leu
Leu Asp Glu Lys Glu Pro Glu Val Leu Gln Asp 675 680 685Ser Leu Gly
Arg Cys Tyr Ser Thr Pro Ser Gly Tyr Leu Glu Leu Pro 690 695 700Asp
Leu Gly Gln Pro Tyr Ser Ser Ala Val Tyr Ser Leu Glu Glu Gln705 710
715 720Tyr Leu Gly Leu Ala Leu Asp Val Asp Arg Ile Lys Lys Asp Gln
Glu 725 730 735Glu Glu Glu Asp Gln Gly Pro Pro Cys Pro Arg Leu Ser
Arg Glu Leu 740 745 750Leu Glu Val Val Glu Pro Glu Val Leu Gln Asp
Ser Leu Asp Arg Cys 755 760 765Tyr Ser Thr Pro Ser Ser Cys Leu Glu
Gln Pro Asp Ser Cys Gln Pro 770 775 780Tyr Gly Ser Ser Phe Tyr Ala
Leu Glu Glu Lys His Val Gly Phe Ser785 790 795 800Leu Asp Val Gly
Glu Ile Glu Lys Lys Gly Lys Gly Lys Lys Arg Arg 805 810 815Gly Arg
Arg Ser Lys Lys Glu Arg Arg Arg Gly Arg Lys Glu Gly Glu 820 825
830Glu Asp Gln Asn Pro Pro Cys Pro Arg Leu Asn Ser Met Leu Met Glu
835 840 845Val Glu Glu Pro Glu Val Leu Gln Asp Ser Leu Asp Ile Cys
Tyr Ser 850 855 860Thr Pro Ser Met Tyr Phe Glu Leu Pro Asp Ser Phe
Gln His Tyr Arg865 870 875 880Ser Val Phe Tyr Ser Phe Glu Glu Glu
His Ile Ser Phe Ala Leu Tyr 885 890 895Val Asp Asn Arg Phe Phe Thr
Leu Thr Val Thr Ser Leu His Leu Val 900 905 910Phe Gln Met Gly Val
Ile Phe Pro Gln 915 92017664DNAHomo sapiens 17aacccaatga tcctgcagca
gcccttgcag cgaggccccc
agggaggggc ccagcgcctc 60ccgcgggccg ccttgggggt gacttggggc ctggacgcca
gctcccctct ccgaggagct 120gtgcccatga gcaccaagcg gcgcctggag
gaggagcagg agcctctgcg caagcagttt 180ctgtctgagg agaacatggc
cacccacttc tctcaactca gcctgcacaa tgaccacccc 240tactgcagcc
cccccatgac cttctcccca gccctgcccc cactcaggag cccttgctct
300gagctgcttc tctggcgcta tcctggcagc ctcatccctg aggccctccg
tctgctgagg 360ctgggggaca cccccagtcc cccctaccct gcaaccccag
ctggggacat aatggagctc 420tgagtgctgg tggacagtgc ccctcccacc
ttccttcttc cccacaacag aagagaccag 480cgactcccgc aaagggacaa
ggttcctccc tctcctgcag agtaggcatc tgggcaccaa 540gaccttccct
caacagagga cactgagccc aacggagttc tgggatggga ggggtgggag
600catgggaagg gaggcatccc acccccaaga agaactgaat aaagattgct
gagcaaagga 660aggc 66418138PRTHomo sapiens 18Met Ile Leu Gln Gln
Pro Leu Gln Arg Gly Pro Gln Gly Gly Ala Gln 1 5 10 15Arg Leu Pro
Arg Ala Ala Leu Gly Val Thr Trp Gly Leu Asp Ala Ser 20 25 30Ser Pro
Leu Arg Gly Ala Val Pro Met Ser Thr Lys Arg Arg Leu Glu 35 40 45Glu
Glu Gln Glu Pro Leu Arg Lys Gln Phe Leu Ser Glu Glu Asn Met 50 55
60Ala Thr His Phe Ser Gln Leu Ser Leu His Asn Asp His Pro Tyr Cys65
70 75 80Ser Pro Pro Met Thr Phe Ser Pro Ala Leu Pro Pro Leu Arg Ser
Pro 85 90 95Cys Ser Glu Leu Leu Leu Trp Arg Tyr Pro Gly Ser Leu Ile
Pro Glu 100 105 110Ala Leu Arg Leu Leu Arg Leu Gly Asp Thr Pro Ser
Pro Pro Tyr Pro 115 120 125Ala Thr Pro Ala Gly Asp Ile Met Glu Leu
130 135192056DNAHomo sapiens 19ggaaccgcgg ctgctggaca agaggggtgc
ggtggatact gacctttgct ccggcctcgt 60cgtgaagaca cagcgcatct ccccgctgta
ggcttctccc acagaacccg tttcgggcct 120cagagcgtct ggtgagatgc
tgttgccgct gctgctgctg ctacccatgt gctgggccgt 180ggaggtcaag
aggccccggg gcgtctccct caccaatcat cacttctacg atgagtccaa
240gcctttcacc tgcctggacg gttcggccac catcccattt gatcaggtca
acgatgacta 300ttgcgactgc aaagatggct ctgacgagcc aggcacggct
gcctgtccta atggcagctt 360ccactgcacc aacactggct ataagcccct
gtatatcccc tccaaccggg tcaacgatgg 420tgtttgtgac tgctgcgatg
gaacagacga gtacaacagc ggcgtcatct gtgagaacac 480ctgcaaagag
aagggccgta aggagagaga gtccctgcag cagatggccg aggtcacccg
540cgaagggttc cgtctgaaga agatccttat tgaggactgg aagaaggcac
gggaggagaa 600gcagaaaaag ctcattgagc tacaggctgg gaagaagtct
ctggaagacc aggtggagat 660gctgcggaca gtgaaggagg aagctgagaa
gccagagaga gaggccaaag agcagcacca 720gaagctgtgg gaagagcagc
tggctgctgc caaggcccaa caggagcagg agctggcggc 780tgatgccttc
aaggagctgg atgatgacat ggacgggacg gtctcggtga ctgagctgca
840gactcacccg gagctggaca cagatgggga tggggcgttg tcagaagcgg
aagctcaggc 900cctcctcagt ggggacacac agacagacgc cacctctttc
tacgaccgcg tctgggccgc 960catcagggac aagtaccggt ccgaggcact
gcccaccgac cttccagcac cttctgcccc 1020tgacttgacg gagcccaagg
aggagcagcc gccagtgccc tcgtcgccca cagaggagga 1080ggaggaggag
gaggaggagg aagaagaggc tgaagaagag gaggaggagg aggattccga
1140ggaggcccca ccgccactgt cacccccgca gccggccagc cctgctgagg
aagacaaaat 1200gccgccctac gacgagcaga cgcaggcctt catcgatgct
gcccaggagg cccgcaacaa 1260gttcgaggag gccgagcggt cgctgaagga
catggaggag tccatcagga acctggagca 1320agagatttct tttgactttg
gccccaacgg ggagtttgct tacctgtaca gccagtgcta 1380cgagctcacc
accaacgaat acgtctaccg cctctgcccc ttcaagcttg tctcgcagaa
1440acccaaactc gggggctctc ccaccagcct tggcacctgg ggctcatgga
ttggccccga 1500ccacgacaag ttcagtgcca tgaagtatga gcaaggcacg
ggctgctggc agggccccaa 1560ccgctccacc accgtgcgcc tcctgtgcgg
gaaagagacc atggtgacca gcaccacaga 1620gcccagtcgc tgcgagtacc
tcatggagct gatgacgcca gccgcctgcc cggagccacc 1680gcctgaagca
cccaccgaag acgaccatga cgagctctag ctggatgggc gcagagaacc
1740tcaagaaggc atgaagccag cccctgcagt gccgtccacc cgcccctctg
ggcctgcctg 1800tggctctgtt gccctcctct gtggcggcag gacctttgtg
gggcttcgtg ccctgctctg 1860gggcccaggc ggggctggtc cacattccca
ggccccaaca gcctccaaag atgggtaaag 1920gagcttgccc tccctgggcc
ccccaccttg gtgactcgcc ccaccacccc cagccctgtc 1980cctgccaccc
ctcctagtgg ggactagtga atgacttgac ctgtgacctc aatacaataa
2040atgtgatccc ccaccc 205620527PRTHomo sapiens 20Met Leu Leu Pro
Leu Leu Leu Leu Leu Pro Met Cys Trp Ala Val Glu 1 5 10 15Val Lys
Arg Pro Arg Gly Val Ser Leu Thr Asn His His Phe Tyr Asp 20 25 30Glu
Ser Lys Pro Phe Thr Cys Leu Asp Gly Ser Ala Thr Ile Pro Phe 35 40
45Asp Gln Val Asn Asp Asp Tyr Cys Asp Cys Lys Asp Gly Ser Asp Glu
50 55 60Pro Gly Thr Ala Ala Cys Pro Asn Gly Ser Phe His Cys Thr Asn
Thr65 70 75 80Gly Tyr Lys Pro Leu Tyr Ile Pro Ser Asn Arg Val Asn
Asp Gly Val 85 90 95Cys Asp Cys Cys Asp Gly Thr Asp Glu Tyr Asn Ser
Gly Val Ile Cys 100 105 110Glu Asn Thr Cys Lys Glu Lys Gly Arg Lys
Glu Arg Glu Ser Leu Gln 115 120 125Gln Met Ala Glu Val Thr Arg Glu
Gly Phe Arg Leu Lys Lys Ile Leu 130 135 140Ile Glu Asp Trp Lys Lys
Ala Arg Glu Glu Lys Gln Lys Lys Leu Ile145 150 155 160Glu Leu Gln
Ala Gly Lys Lys Ser Leu Glu Asp Gln Val Glu Met Leu 165 170 175Arg
Thr Val Lys Glu Glu Ala Glu Lys Pro Glu Arg Glu Ala Lys Glu 180 185
190Gln His Gln Lys Leu Trp Glu Glu Gln Leu Ala Ala Ala Lys Ala Gln
195 200 205Gln Glu Gln Glu Leu Ala Ala Asp Ala Phe Lys Glu Leu Asp
Asp Asp 210 215 220Met Asp Gly Thr Val Ser Val Thr Glu Leu Gln Thr
His Pro Glu Leu225 230 235 240Asp Thr Asp Gly Asp Gly Ala Leu Ser
Glu Ala Glu Ala Gln Ala Leu 245 250 255Leu Ser Gly Asp Thr Gln Thr
Asp Ala Thr Ser Phe Tyr Asp Arg Val 260 265 270Trp Ala Ala Ile Arg
Asp Lys Tyr Arg Ser Glu Ala Leu Pro Thr Asp 275 280 285Leu Pro Ala
Pro Ser Ala Pro Asp Leu Thr Glu Pro Lys Glu Glu Gln 290 295 300Pro
Pro Val Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu Glu Glu305 310
315 320Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Ser Glu
Glu 325 330 335Ala Pro Pro Pro Leu Ser Pro Pro Gln Pro Ala Ser Pro
Ala Glu Glu 340 345 350Asp Lys Met Pro Pro Tyr Asp Glu Gln Thr Gln
Ala Phe Ile Asp Ala 355 360 365Ala Gln Glu Ala Arg Asn Lys Phe Glu
Glu Ala Glu Arg Ser Leu Lys 370 375 380Asp Met Glu Glu Ser Ile Arg
Asn Leu Glu Gln Glu Ile Ser Phe Asp385 390 395 400Phe Gly Pro Asn
Gly Glu Phe Ala Tyr Leu Tyr Ser Gln Cys Tyr Glu 405 410 415Leu Thr
Thr Asn Glu Tyr Val Tyr Arg Leu Cys Pro Phe Lys Leu Val 420 425
430Ser Gln Lys Pro Lys Leu Gly Gly Ser Pro Thr Ser Leu Gly Thr Trp
435 440 445Gly Ser Trp Ile Gly Pro Asp His Asp Lys Phe Ser Ala Met
Lys Tyr 450 455 460Glu Gln Gly Thr Gly Cys Trp Gln Gly Pro Asn Arg
Ser Thr Thr Val465 470 475 480Arg Leu Leu Cys Gly Lys Glu Thr Met
Val Thr Ser Thr Thr Glu Pro 485 490 495Ser Arg Cys Glu Tyr Leu Met
Glu Leu Met Thr Pro Ala Ala Cys Pro 500 505 510Glu Pro Pro Pro Glu
Ala Pro Thr Glu Asp Asp His Asp Glu Leu 515 520 52521384DNAHomo
sapiens 21atgcctaaat caaaggaact tgtttcttca agctcttctg gcagtgattc
tgacagtgag 60gttgacaaaa agttaaagag gaaaaagcaa gttgctccag aaaaacctgt
aaagaaacaa 120aagacaggtg agacttcgag agccctgtca tcttctaaac
agagcagcag cagcagagat 180gataacatgt ttcagattgg gaaaatgagg
tacgttagtg ttcgcgattt taaaggcaaa 240gtgctaattg atattagaga
atattggatg gatcctgaag gtgaaatgaa accaggaaga 300aaaggtattt
ctttaaatcc agaacaatgg agccagctga aggaacagat ctctgatata
360gatgacgcag taagaaagct gtga 38422127PRTHomo sapiens 22Met Pro Lys
Ser Lys Glu Leu Val Ser Ser Ser Ser Ser Gly Ser Asp 1 5 10 15Ser
Asp Ser Glu Val Asp Lys Lys Leu Lys Arg Lys Lys Gln Val Ala 20 25
30Pro Glu Lys Pro Val Lys Lys Gln Lys Thr Gly Glu Thr Ser Arg Ala
35 40 45Leu Ser Ser Ser Lys Gln Ser Ser Ser Ser Arg Asp Asp Asn Met
Phe 50 55 60Gln Ile Gly Lys Met Arg Tyr Val Ser Val Arg Asp Phe Lys
Gly Lys65 70 75 80Val Leu Ile Asp Ile Arg Glu Tyr Trp Met Asp Pro
Glu Gly Glu Met 85 90 95Lys Pro Gly Arg Lys Gly Ile Ser Leu Asn Pro
Glu Gln Trp Ser Gln 100 105 110Leu Lys Glu Gln Ile Ser Asp Ile Asp
Asp Ala Val Arg Lys Leu 115 120 125231554DNAHomo sapiens
23gaccacaatg gcggccgcca ccctgctgcg cgcgacgccc cacttcagcg gtctcgccgc
60cggccggacc ttcctgctgc agggtctgtt gcggctgctg aaagccccgg cattgcctct
120cttgtgccgc ggcctggccg tggaggccaa gaagacttac gtgcgcgaca
agccacatgt 180gaatgtgggt accatcggcc atgtggacca cgggaagacc
acgctgactg cagccatcac 240gaagattcta gctgagggag gtggggctaa
gttcaagaag tacgaggaga ttgacaatgc 300cccggaggag cgagctcggg
gtatcaccat caatgcggct catgtggagt atagcactgc 360cgcccgccac
tacgcccaca cagactgccc gggtcatgca gattatgtta agaatatgat
420cacaggcact gcacccctcg acggctgcat cctggtggta gcagccaatg
acggccccat 480gccccagacc cgagagcact tattactggc cagacagatt
ggggtggagc atgtggtggt 540gtatgtgaac aaggctgacg ctgtccagga
ctctgagatg gtggaactgg tggaactgga 600gatccgggag ctgctcaccg
agtttggcta taaaggggag gagaccccag tcatcgtagg 660ctctgctctc
tgtgcccttg agggtcggga ccctgagtta ggcctgaagt ctgtgcagaa
720gctactggat gctgtggaca cttacatccc agtgcccgcc cgggacctgg
agaagccttt 780cctgctgcct gtggaggcgg tgtactccgt ccctggccgt
ggcaccgtgg tgacaggtac 840actagagcgt ggcattttaa agaagggaga
cgagtgtgag ctcctaggac atagcaagaa 900catccgcact gtggtgacag
gcattgagat gttccacaag agcctggaga gggccgaggc 960cggagataac
ctcggggccc tggtccgagg cttgaagcgg gaggacttgc ggcggggcct
1020ggtcatggtc aagccaggtt ccatcaagcc ccaccagaag gtggaggccc
aggtttacat 1080cctcagcaag gaggaaggtg gccgccacaa gccctttgtg
tcccacttca tgcctgtcat 1140gttctccctg acttggaaca tggcctgtcg
gattatcctg cccccagaga aggagcttgc 1200catgcccggg gaggacctga
agttcaacct aatcttgcgg cagccaatga tcttagagaa 1260aggccagcgt
ttcaccctgc gagatggcaa ccggactatt ggcaccggtc tagtcaccaa
1320cacgctggcc atgactgagg aggagaagaa tatcaaatgg ggttgagtgt
gcagatctct 1380gctcagcttc ccttgcgttt aaggcctgcc ctagccaggg
ctccctcctg cttccagtac 1440cctctcatgg cataggctgc aacccagcag
agggcagcta gatggacatt tcccctgctc 1500ggaagggttg gcctgcctgg
ctggggaggt cagtaaactt tgaatagtaa gcca 155424452PRTHomo sapiens
24Met Ala Ala Ala Thr Leu Leu Arg Ala Thr Pro His Phe Ser Gly Leu 1
5 10 15Ala Ala Gly Arg Thr Phe Leu Leu Gln Gly Leu Leu Arg Leu Leu
Lys 20 25 30Ala Pro Ala Leu Pro Leu Leu Cys Arg Gly Leu Ala Val Glu
Ala Lys 35 40 45Lys Thr Tyr Val Arg Asp Lys Pro His Val Asn Val Gly
Thr Ile Gly 50 55 60His Val Asp His Gly Lys Thr Thr Leu Thr Ala Ala
Ile Thr Lys Ile65 70 75 80Leu Ala Glu Gly Gly Gly Ala Lys Phe Lys
Lys Tyr Glu Glu Ile Asp 85 90 95Asn Ala Pro Glu Glu Arg Ala Arg Gly
Ile Thr Ile Asn Ala Ala His 100 105 110Val Glu Tyr Ser Thr Ala Ala
Arg His Tyr Ala His Thr Asp Cys Pro 115 120 125Gly His Ala Asp Tyr
Val Lys Asn Met Ile Thr Gly Thr Ala Pro Leu 130 135 140Asp Gly Cys
Ile Leu Val Val Ala Ala Asn Asp Gly Pro Met Pro Gln145 150 155
160Thr Arg Glu His Leu Leu Leu Ala Arg Gln Ile Gly Val Glu His Val
165 170 175Val Val Tyr Val Asn Lys Ala Asp Ala Val Gln Asp Ser Glu
Met Val 180 185 190Glu Leu Val Glu Leu Glu Ile Arg Glu Leu Leu Thr
Glu Phe Gly Tyr 195 200 205Lys Gly Glu Glu Thr Pro Val Ile Val Gly
Ser Ala Leu Cys Ala Leu 210 215 220Glu Gly Arg Asp Pro Glu Leu Gly
Leu Lys Ser Val Gln Lys Leu Leu225 230 235 240Asp Ala Val Asp Thr
Tyr Ile Pro Val Pro Ala Arg Asp Leu Glu Lys 245 250 255Pro Phe Leu
Leu Pro Val Glu Ala Val Tyr Ser Val Pro Gly Arg Gly 260 265 270Thr
Val Val Thr Gly Thr Leu Glu Arg Gly Ile Leu Lys Lys Gly Asp 275 280
285Glu Cys Glu Leu Leu Gly His Ser Lys Asn Ile Arg Thr Val Val Thr
290 295 300Gly Ile Glu Met Phe His Lys Ser Leu Glu Arg Ala Glu Ala
Gly Asp305 310 315 320Asn Leu Gly Ala Leu Val Arg Gly Leu Lys Arg
Glu Asp Leu Arg Arg 325 330 335Gly Leu Val Met Val Lys Pro Gly Ser
Ile Lys Pro His Gln Lys Val 340 345 350Glu Ala Gln Val Tyr Ile Leu
Ser Lys Glu Glu Gly Gly Arg His Lys 355 360 365Pro Phe Val Ser His
Phe Met Pro Val Met Phe Ser Leu Thr Trp Asn 370 375 380Met Ala Cys
Arg Ile Ile Leu Pro Pro Glu Lys Glu Leu Ala Met Pro385 390 395
400Gly Glu Asp Leu Lys Phe Asn Leu Ile Leu Arg Gln Pro Met Ile Leu
405 410 415Glu Lys Gly Gln Arg Phe Thr Leu Arg Asp Gly Asn Arg Thr
Ile Gly 420 425 430Thr Gly Leu Val Thr Asn Thr Leu Ala Met Thr Glu
Glu Glu Lys Asn 435 440 445Ile Lys Trp Gly 450252201DNAHomo sapiens
25tttttttttt cgtcttagcc acgcagaagt cgcgtgtcta gtttgtttcg acgccggacc
60gcgtaagaga cgatgatgtt gggcacggaa ggtggagagg gattcgtggt gaaggtccgg
120ggcttgccct ggtcttgctc ggccgatgaa gtgcagaggt ttttttctga
ctgcaaaatt 180caaaatgggg ctcaaggtat tcgtttcatc tacaccagag
aaggcagacc aagtggcgag 240gcttttgttg aacttgaatc agaagatgaa
gtcaaattgg ccctgaaaaa agacagagaa 300actatgggac acagatatgt
tgaagtattc aagtcaaaca acgttgaaat ggattgggtg 360ttgaagcata
ctggtccaaa tagtcctgac acggccaatg atggctttgt acggcttaga
420ggacttccct ttggatgtag caaggaagaa attgttcagt tcttctcagg
gttggaaatc 480gtgccaaatg ggataacatt gccggtggac ttccagggga
ggagtacggg ggaggccttc 540gtgcagtttg cttcacagga aatagctgaa
aaggctctaa agaaacacaa ggaaagaata 600gggcacaggt atattgaaat
ctttaagagc agtagagctg aagttagaac tcattatgat 660ccaccacgaa
agcttatggc catgcagcgg ccaggtcctt atgacagacc tggggctggt
720agagggtata acagcattgg cagaggagct ggctttgaga ggatgaggcg
tggtgcttat 780ggtggaggct atggaggcta tgatgattac aatggctata
atgatggcta tggatttggg 840tcagatagat ttggaagaga cctcaattac
tgtttttcag gaatgtctga tcacagatac 900ggggatggtg gctctacttt
ccagagcaca acaggacact gtgtacacat gcggggatta 960ccttacagag
ctactgagaa tgacatttat aatttttttt caccgctcaa ccctgtgaga
1020gtacacattg aaattggtcc tgatggcaga gtaactggtg aagcagatgt
cgagttcgca 1080actcatgaag atgctgtggc agctatgtca aaagacaaag
caaatatgca acacagatat 1140gtagaactct tcttgaattc tacagcagga
gcaagcggtg gtgcttacga acacagatat 1200gtagaactct tcttgaattc
tacagcagga gcaagcggtg gtgcttatgg tagccaaatg 1260atgggaggca
tgggcttgtc aaaccagtcc agctacgggg gcccagccag ccagcagctg
1320agtgggggtt acggaggcgg ctacggtggc cagagcagca tgagtggata
cgaccaagtt 1380ttacaggaaa actccagtga ttttcaatca aacattgcat
aggtaaccaa ggagcagtga 1440acagcagcta ctacagtagt ggaagccgtg
catctatggg cgtgaacgga atgggagggt 1500tgtctagcat gtccagtatg
agtggtggat ggggaatgta attgatcgat cctgatcact 1560gactcttggt
caaccttttt tttttttttt ttttctttaa gaaaacttca gtttaacagt
1620ttctgcaata caagcttgtg atttatgctt actctaagtg gaaatcagga
ttgttatgaa 1680gacttaaggc ccagtatttt tgaatacaat actcatctag
gatgtaacag tgaagctgag 1740taaactataa ctgttaaact taagttccag
cttttctcaa gttagttata ggatgtactt 1800aagcagtaag cgtatttagg
taaaagcagt tgaattatgt taaatgttgc cctttgccac 1860gttaaattga
acactgtttt ggatgcatgt tgaaagacat gcttttattt tttttgtaaa
1920acaatatagg agctgtgtct actattaaaa gtgaaacatt ttggcatgtt
tgttaattct 1980agtttcattt aataacctgt aaggcacgta agtttaagct
tttttttttt ttaagttaat 2040gggaaaaatt tgagacgcaa taccaatact
taggattttg gtcttggtgt ttgtatgaaa 2100ttctgaggcc ttgatttaaa
tctttcattg tattgtgatt tccttttagg tatattgcgc 2160taagtgaaac
ttgtcaaata aatcctcctt ttaaaaactg c 220126449PRTHomo sapiens 26Met
Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 1 5 10
15Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser
20 25 30Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr
Thr 35 40 45Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu
Ser
Glu 50 55 60Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met
Gly His65 70 75 80Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu
Met Asp Trp Val 85 90 95Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr
Ala Asn Asp Gly Phe 100 105 110Val Arg Leu Arg Gly Leu Pro Phe Gly
Cys Ser Lys Glu Glu Ile Val 115 120 125Gln Phe Phe Ser Gly Leu Glu
Ile Val Pro Asn Gly Ile Thr Leu Pro 130 135 140Val Asp Phe Gln Gly
Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala145 150 155 160Ser Gln
Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 165 170
175Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg
180 185 190Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg
Pro Gly 195 200 205Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn
Ser Ile Gly Arg 210 215 220Gly Ala Gly Phe Glu Arg Met Arg Arg Gly
Ala Tyr Gly Gly Gly Tyr225 230 235 240Gly Gly Tyr Asp Asp Tyr Asn
Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 245 250 255Ser Asp Arg Phe Gly
Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 260 265 270Asp His Arg
Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 275 280 285His
Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 290 295
300Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile
Glu305 310 315 320Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp
Val Glu Phe Ala 325 330 335Thr His Glu Asp Ala Val Ala Ala Met Ser
Lys Asp Lys Ala Asn Met 340 345 350Gln His Arg Tyr Val Glu Leu Phe
Leu Asn Ser Thr Ala Gly Ala Ser 355 360 365Gly Gly Ala Tyr Glu His
Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 370 375 380Ala Gly Ala Ser
Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met385 390 395 400Gly
Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 405 410
415Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly
420 425 430Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser
Asn Ile 435 440 445Ala271852DNAHomo sapiens 27acagcccttc gtggggccct
gggcaccctg caccagctgg gcatcgtcgt cggcatcctc 60atcgcccagg tgttcggcct
ggactccatc atgggcaaca aggacctgtg gcccctgctg 120ctgagcatca
tcttcatccc ggccctgctg cagtgcatcg tgctgccctt ctgccccgag
180agtccccgct tcctgctcat caaccgcaac gaggagaacc gggccaagag
tgtgctaaag 240aagctgcgcg ggacagctga cgtgacccat gacctgcagg
agatgaagga agagagtcgg 300cagatgatgc gggagaagaa ggtcaccatc
ctggagctgt tccgctcccc cgcctaccgc 360cagcccatcc tcatcgctgt
ggtgctgcag ctgtcccagc agctgtctgg catcaacgct 420gtcttctatt
actccacgag catcttcgag aaggcggggg tgcagcagcc tgtgtatgcc
480accattggct ccggtatcgt caacacggcc ttcactgtcg tgtcgctgtt
tgtggtggag 540cgagcaggcc ggcggaccct gcacctcata ggcctcgctg
gcatggcggg ttgtgccata 600ctcatgacca tcgcgctagc actgctggag
cagctaccct ggatgtccta tctgagcatc 660gtggccatct ttggctttgt
ggccttcttt gaagtgggtc ctggccccat cccatggttc 720atcgtggctg
aactcttcag ccagggtcca cgtccagctg ccattgccgt tgcaggcttc
780tccaactgga cctcaaattt cattgtgggc atgtgcttcc agtatgtgga
gcaactgtgt 840ggtccctacg tcttcatcat cttcactgtg ctcctggttc
tgttcttcat cttcacctac 900ttcaaagttc ctgagactaa aggccggacc
ttcgatgaga tcgcttccgg cttccggcag 960gggggagcca gccaaagtga
caagacaccc gaggagctgt tccatcccct gggggctgat 1020tcccaagtgt
gagtcgcccc agatcaccag cccggcctgc tcccagcagc cctaaggatc
1080tctcaggagc acaggcagct ggatgagact tccaaacctg acagatgtca
gccgagccgg 1140gcctggggct cctttctcca gccagcaatg atgtccagaa
gaatattcag gacttaacgg 1200ctccaggatt ttaacaaaag caagactgtt
gctcaaatct attcagacaa gcaacaggtt 1260ttataatttt tttattactg
attttgttat ttttatatca gcctgagtct cctgtgccca 1320catcccaggc
ttcaccctga atggttccat gcctgagggt ggagactaag ccctgtcgag
1380acacttgcct tcttcaccca gctaatctgt agggctggac ctatgtccta
aggacacact 1440aatcgaacta tgaactacaa agcttctatc ccaggaggtg
gctatggcca cccgttctgc 1500tggcctggat ctccccactc taggggtcag
gctccattag gatttgcccc ttcccatctc 1560ttcctaccca accactcaaa
ttaatctttc tttacctgag accagttggg agcactggag 1620tgcagggagg
agaggggaag ggccagtctg ggctgccggg ttctagtctc ctttgcactg
1680agggccacac tattaccatg agaagagggc ctgtgggagc ctgcaaactc
actgctcaag 1740aagacatgga gactcctgcc ctgttgtgta tagatgcaag
atatttatat atatttttgg 1800ttgtcaatat taaatacaga cactaagtta
tagtaaaaaa aaaaaaaaaa aa 185228343PRTHomo sapiens 28Thr Ala Leu Arg
Gly Ala Leu Gly Thr Leu His Gln Leu Gly Ile Val 1 5 10 15Val Gly
Ile Leu Ile Ala Gln Val Phe Gly Leu Asp Ser Ile Met Gly 20 25 30Asn
Lys Asp Leu Trp Pro Leu Leu Leu Ser Ile Ile Phe Ile Pro Ala 35 40
45Leu Leu Gln Cys Ile Val Leu Pro Phe Cys Pro Glu Ser Pro Arg Phe
50 55 60Leu Leu Ile Asn Arg Asn Glu Glu Asn Arg Ala Lys Ser Val Leu
Lys65 70 75 80Lys Leu Arg Gly Thr Ala Asp Val Thr His Asp Leu Gln
Glu Met Lys 85 90 95Glu Glu Ser Arg Gln Met Met Arg Glu Lys Lys Val
Thr Ile Leu Glu 100 105 110Leu Phe Arg Ser Pro Ala Tyr Arg Gln Pro
Ile Leu Ile Ala Val Val 115 120 125Leu Gln Leu Ser Gln Gln Leu Ser
Gly Ile Asn Ala Val Phe Tyr Tyr 130 135 140Ser Thr Ser Ile Phe Glu
Lys Ala Gly Val Gln Gln Pro Val Tyr Ala145 150 155 160Thr Ile Gly
Ser Gly Ile Val Asn Thr Ala Phe Thr Val Val Ser Leu 165 170 175Phe
Val Val Glu Arg Ala Gly Arg Arg Thr Leu His Leu Ile Gly Leu 180 185
190Ala Gly Met Ala Gly Cys Ala Ile Leu Met Thr Ile Ala Leu Ala Leu
195 200 205Leu Glu Gln Leu Pro Trp Met Ser Tyr Leu Ser Ile Val Ala
Ile Phe 210 215 220Gly Phe Val Ala Phe Phe Glu Val Gly Pro Gly Pro
Ile Pro Trp Phe225 230 235 240Ile Val Ala Glu Leu Phe Ser Gln Gly
Pro Arg Pro Ala Ala Ile Ala 245 250 255Val Ala Gly Phe Ser Asn Trp
Thr Ser Asn Phe Ile Val Gly Met Cys 260 265 270Phe Gln Tyr Val Glu
Gln Leu Cys Gly Pro Tyr Val Phe Ile Ile Phe 275 280 285Thr Val Leu
Leu Val Leu Phe Phe Ile Phe Thr Tyr Phe Lys Val Pro 290 295 300Glu
Thr Lys Gly Arg Thr Phe Asp Glu Ile Ala Ser Gly Phe Arg Gln305 310
315 320Gly Gly Ala Ser Gln Ser Asp Lys Thr Pro Glu Glu Leu Phe His
Pro 325 330 335Leu Gly Ala Asp Ser Gln Val 340295368DNAHomo sapiens
29ggaatcagag aagatcattg ctgagttgaa tgaaacttgg gaagagaagc ttcgtaaaac
60agaggccatc agaatggaga gagaggcttt gttggctgag atgggagttg ccattcggga
120agatggagga accctagggg ttttctcacc taaaaagacc ccacatcttg
ttaacctcaa 180tgaagaccca ctaatgtctg agtgcctact ttattacatc
aaagatggaa ttacaagggt 240tggccaagca gatgctgagc ggcgccagga
catagtgctg agcggggctc acattaaaga 300agagcattgt atcttccgga
gtgagagaag caacagcggg gaagttatcg tgaccttaga 360gccctgtgag
cgctcagaaa cctacgtaaa tggcaagagg gtgtcccagc ctgttcagct
420gcgctcagga aaccgtatca tcatgggtaa aaaccatgtt ttccgcttta
accacccgga 480acaagcacga gctgagcgag agaagactcc ttctgctgag
accccctctg agcctgtgga 540ctggacattt gcccagaggg agcttctgga
aaaacaagga attgatatga aacaagagat 600ggagaaaagg ctacaggaaa
tggagatctt atacaaaaag gagaaggaag aagcagatct 660tcttttggag
cagcagagac tggactatga gagtaaattg caggccttgc agaagcaggt
720tgaaacccga tctctggctg cagaaacaac tgaagaggag gaagaagagg
aagaagttcc 780ttggacacag catgaatttg agttggccca atgggccttc
cggaaatgga agtctcatca 840gtttacttca ttacgggact tactctgggg
caatgccgtg tacctaaagg aggccaatgc 900catcagtgtg gaactgaaaa
agaaggtgca gtttcagttt gttctgctga ctgacacact 960gtactcccct
ttgcctcctg aattacttcc cactgagatg gaaaaaactc atgaggacag
1020gcctttccct cgcacagtgg tagcagtaga agtccaggat ttgaagaatg
gagcaacaca 1080ctattggtct ttggagaaac tcaagcagag gctggatttg
atgcgagaga tgtatgatag 1140ggcaggggag atggcctcca gtgcccaaga
cgaaagcgaa accactgtga ctggcagcga 1200tcccttctat gatcggttcc
actggttcaa acttgtgggg agctccccca ttttccacgg 1260ctgtgtgaac
gagcgccttg ccgaccgcac accctccccc actttttcca cggccgattc
1320cgacatcact gagctggctg acgagcagca agatgagatg gaggattttg
atgatgaggc 1380attcgtggat gacgccggct ctgacgcagg gacggaggag
ggatcagatc tcttcagtga 1440cgggcatgac ccgttttacg accgatcccc
ttggttcatt ttagtgggaa gggcatttgt 1500ttacctgagc aatctgctgt
atcccgtgcc cctgatccac agggtggcca tcgtcagtga 1560gaaaggtgaa
gtgcggggat ttctgcgtgt ggctgtacag gccatcgcag cggatgaaga
1620agctcctgat tatggctctg gaattcgaca gtcaggaaca gctaaaatat
cttttgataa 1680tgaatacttt aatcagagtg acttttcgtc tgttgcaatg
actcgttctg gtctgtcctt 1740ggaggagttg aggattgtgg aaggacaggg
tcagagttct gaggtcatca ctcctccaga 1800agaaatcagt cgaattaatg
acttggattt gaagtcaagc actttgctgg atggtaagat 1860ggtaatggaa
gggttttctg aagagattgg caaccacctg aaactgggca gtgccttcac
1920tttccgagta acagtgttgc aggccagtgg aatcctccca gagtatgcag
atatcttctg 1980tcagttcaac tttttgcatc gccatgatga agcattctcc
acggagcccc tcaaaaacaa 2040tggcagagga agtcccctgg ccttttatca
tgtgcagaat attgcagtgg agatcactga 2100atcatttgtg gattacatca
aaaccaagcc tattgtattt gaagtctttg ggcattatca 2160gcagcaccca
cttcatctgc aaggacagga gcttaacagt ccgcctcagc cgtgccgccg
2220attcttccct ccacccatgc cactgtccaa gccagttcca gccaccaagt
taaacacgat 2280gagcaaaacc agccttggcc agagcatgag caagtatgac
ctcctggttt ggtttgagat 2340cagtgaactg gagcctacag gagagtatat
cccagctgtg gttgaccaca cagcaggctt 2400gccttgccag gggacatttt
tgcttcatca gggcatccag cgaaggatca cagtgaccat 2460tatccatgag
aaggggagcg agctccattg gaaagatgtt cgtgaactgg tggtaggtcg
2520tattcggaat aagcctgagg tggatgaagc tgcagttgat gccatcctct
ccctaaatat 2580tatttctgcc aagtacctga agtcttccca caactctagc
aggaccttct accgctttga 2640ggctgtgtgg gatagctctc tgcataactc
ccttcttctg aaccgagtga caccctatgg 2700agaaaagatc tacatgacct
tgtcggccta cctagagctg gatcattgca tccagccggc 2760tgtcatcacc
aaggatgtgt gcatggtctt ctactcccga gatgccaaga tctcaccacc
2820acgctctctg cgtagcctct ttggcagcgg ctactcaaag tcaccagatt
cgaatcgagt 2880cactggcatt tacgaactca gcttatgcaa aatgtcagac
acaggtagtc caggtatgca 2940gagaaggaga agaaaaatct tagatacgtc
agtggcatat gtgcggggag aagagaactt 3000agcaggctgg cggccccgtg
gagacagcct catccttgag caccagtggg agctggagaa 3060gctggagctc
ctacatgagg tggaaaaaac ccgccacttt ttgctgctgc gtgagagact
3120tggtgacagc atccccaaat ccctgagcga ctcgttatcc cccagcctca
gcagtgggac 3180cctcagcacc tccaccagta tctcctctca gatctcaacc
actacctttg aaagcgccat 3240cacacctagc gagagcagtg gctatgattc
aggagacatc gaaagcctgg tggaccgaga 3300gaaagagctg gctaccaagt
gcctgcaact tctcacccac actttcaaca gagaattcag 3360ccaggtgcac
ggcagcgtca gtgactgtaa gttgtctgat atctctccaa ttggacggga
3420tccctctgag tccagtttca gcagtgccac cctcactccc tcctccacct
gtccctctct 3480ggtagactct aggagcaact ctctggatca gaagacccca
gaagccaatt cccgggcctc 3540tagtccctgc ccagaatttg aacagtttca
gattgtccca gctgtggaaa caccatattt 3600ggcccgagca ggaaaaaacg
aatttctcaa tcttgttcca gatattgaag aaattagacc 3660aagctcagtg
gtctctaaga aaggatacct tcatttcaag gagcctcttt acagtaactg
3720ggctaaacat tttgttgtcg tccgtcggcc ttatgtcttc atctataaca
gtgacaaaga 3780ccctgtggag cgtggaatca ttaacctgtc cacagcacag
gtggagtaca gtgaggacca 3840gcaggccatg gtgaagacac caaacacctt
tgctgtctgc acaaagcacc gtggggtcct 3900tttgcaggcc ctcaatgaca
aagacatgaa cgactggttg tatgccttca acccacttct 3960agctggcaca
atacggtcaa agctttcccg cagatgcccg agccagtcga aatactaagt
4020gactctgccg agtgccctca ctcgccttcg agagataaag aaagcgttac
ctctcatttc 4080tctttgtgat tcttgacggt gactcttgta tgtaatcctg
tggcttaact acttctccct 4140ccttgtccag cacttttcta gctctcccgt
tccccatctc cattgctctg tactcttttc 4200ttttttcttg tgctgagaat
ctcgttagta gcatgtggcc taacaaaagg aaaaaatgtt 4260tttaaacaca
cacacacaca cacacacaca cacacacata cacagacaaa aacacaaaaa
4320ctctgagggg atctggtgaa tctccaaatt attgtgggtg tactttggct
tccttttgta 4380tgataggtcc ccatcatgac cacctctgat gtctgtgctg
ctgtcaccag gcacctttgt 4440ttttcaagac aacatacttt ttttttcttt
tctctgtttg tgatatcact ttaatttttc 4500ttgggtggct tagagactaa
gggaggagac atctggcctt tttagaacct gagaggaaaa 4560aaagagtctt
tttttcccct ctgtctcttt ttgccatggc taatccctgc atttccattc
4620agggaaaagg tggtagtgag catagaactg caacagttat attctgagtc
aaagttgggg 4680ctttttacgg cataattatg gaatttttat ttactggtag
agaggagacg agaggctttt 4740tcagtgggcc tgggacagtg gctgctcttg
actttgtgtg aagggaaatg ccaaggatgc 4800ttctggtgga cttcagggga
ccccagggtt tggccgtggg ccgtgatggc agcaggcggt 4860gggatgcttg
tagctcctca cagcaggatt cctgcccact gttttttctc tgttgggagg
4920gaagctcttt tctaggagtg tctcagttct gcttttggca ttagtgatgg
tggtggtaca 4980gttggaatta gtgccatgtc atacacaaat gttccacaag
gcgggagtgt ttcactttct 5040ggtgataaac ttgatggtca ttgttatgat
taagataatg ccgggcaggc cgggcacagt 5100ggctcacgcc tgtaatccaa
gcacttgggg aggccgaggc gggcagatca cgagatcagg 5160agttcaagac
cagcctggcc aatgtgatga aaccccgtct ctactaaaaa tacaaaatta
5220gtcgggtatg gtggcacatg cctgtaattc cagctgcttg ggagcctgag
gcaggagaac 5280tgcttgaacc caggaggcag aggttgcagt gagccaagat
cgcgctattg cactccagcc 5340tgggtgacag agcaagactc tgcctcag
5368301338PRTHomo sapiens 30Glu Ser Glu Lys Ile Ile Ala Glu Leu Asn
Glu Thr Trp Glu Glu Lys 1 5 10 15Leu Arg Lys Thr Glu Ala Ile Arg
Met Glu Arg Glu Ala Leu Leu Ala 20 25 30Glu Met Gly Val Ala Ile Arg
Glu Asp Gly Gly Thr Leu Gly Val Phe 35 40 45Ser Pro Lys Lys Thr Pro
His Leu Val Asn Leu Asn Glu Asp Pro Leu 50 55 60Met Ser Glu Cys Leu
Leu Tyr Tyr Ile Lys Asp Gly Ile Thr Arg Val65 70 75 80Gly Gln Ala
Asp Ala Glu Arg Arg Gln Asp Ile Val Leu Ser Gly Ala 85 90 95His Ile
Lys Glu Glu His Cys Ile Phe Arg Ser Glu Arg Ser Asn Ser 100 105
110Gly Glu Val Ile Val Thr Leu Glu Pro Cys Glu Arg Ser Glu Thr Tyr
115 120 125Val Asn Gly Lys Arg Val Ser Gln Pro Val Gln Leu Arg Ser
Gly Asn 130 135 140Arg Ile Ile Met Gly Lys Asn His Val Phe Arg Phe
Asn His Pro Glu145 150 155 160Gln Ala Arg Ala Glu Arg Glu Lys Thr
Pro Ser Ala Glu Thr Pro Ser 165 170 175Glu Pro Val Asp Trp Thr Phe
Ala Gln Arg Glu Leu Leu Glu Lys Gln 180 185 190Gly Ile Asp Met Lys
Gln Glu Met Glu Lys Arg Leu Gln Glu Met Glu 195 200 205Ile Leu Tyr
Lys Lys Glu Lys Glu Glu Ala Asp Leu Leu Leu Glu Gln 210 215 220Gln
Arg Leu Asp Tyr Glu Ser Lys Leu Gln Ala Leu Gln Lys Gln Val225 230
235 240Glu Thr Arg Ser Leu Ala Ala Glu Thr Thr Glu Glu Glu Glu Glu
Glu 245 250 255Glu Glu Val Pro Trp Thr Gln His Glu Phe Glu Leu Ala
Gln Trp Ala 260 265 270Phe Arg Lys Trp Lys Ser His Gln Phe Thr Ser
Leu Arg Asp Leu Leu 275 280 285Trp Gly Asn Ala Val Tyr Leu Lys Glu
Ala Asn Ala Ile Ser Val Glu 290 295 300Leu Lys Lys Lys Val Gln Phe
Gln Phe Val Leu Leu Thr Asp Thr Leu305 310 315 320Tyr Ser Pro Leu
Pro Pro Glu Leu Leu Pro Thr Glu Met Glu Lys Thr 325 330 335His Glu
Asp Arg Pro Phe Pro Arg Thr Val Val Ala Val Glu Val Gln 340 345
350Asp Leu Lys Asn Gly Ala Thr His Tyr Trp Ser Leu Glu Lys Leu Lys
355 360 365Gln Arg Leu Asp Leu Met Arg Glu Met Tyr Asp Arg Ala Gly
Glu Met 370 375 380Ala Ser Ser Ala Gln Asp Glu Ser Glu Thr Thr Val
Thr Gly Ser Asp385 390 395 400Pro Phe Tyr Asp Arg Phe His Trp Phe
Lys Leu Val Gly Ser Ser Pro 405 410 415Ile Phe His Gly Cys Val Asn
Glu Arg Leu Ala Asp Arg Thr Pro Ser 420 425 430Pro Thr Phe Ser Thr
Ala Asp Ser Asp Ile Thr Glu Leu Ala Asp Glu 435 440 445Gln Gln Asp
Glu Met Glu Asp Phe Asp Asp Glu Ala Phe Val Asp Asp 450 455 460Ala
Gly Ser Asp Ala Gly Thr Glu Glu Gly Ser Asp Leu Phe Ser Asp465 470
475 480Gly His Asp Pro Phe Tyr Asp Arg Ser Pro Trp Phe Ile Leu Val
Gly 485 490 495Arg Ala Phe Val Tyr Leu Ser Asn Leu Leu Tyr Pro Val
Pro Leu Ile 500 505 510His Arg Val Ala Ile Val Ser Glu Lys Gly Glu
Val Arg Gly Phe Leu 515 520 525Arg Val Ala Val Gln Ala Ile Ala
Ala
Asp Glu Glu Ala Pro Asp Tyr 530 535 540Gly Ser Gly Ile Arg Gln Ser
Gly Thr Ala Lys Ile Ser Phe Asp Asn545 550 555 560Glu Tyr Phe Asn
Gln Ser Asp Phe Ser Ser Val Ala Met Thr Arg Ser 565 570 575Gly Leu
Ser Leu Glu Glu Leu Arg Ile Val Glu Gly Gln Gly Gln Ser 580 585
590Ser Glu Val Ile Thr Pro Pro Glu Glu Ile Ser Arg Ile Asn Asp Leu
595 600 605Asp Leu Lys Ser Ser Thr Leu Leu Asp Gly Lys Met Val Met
Glu Gly 610 615 620Phe Ser Glu Glu Ile Gly Asn His Leu Lys Leu Gly
Ser Ala Phe Thr625 630 635 640Phe Arg Val Thr Val Leu Gln Ala Ser
Gly Ile Leu Pro Glu Tyr Ala 645 650 655Asp Ile Phe Cys Gln Phe Asn
Phe Leu His Arg His Asp Glu Ala Phe 660 665 670Ser Thr Glu Pro Leu
Lys Asn Asn Gly Arg Gly Ser Pro Leu Ala Phe 675 680 685Tyr His Val
Gln Asn Ile Ala Val Glu Ile Thr Glu Ser Phe Val Asp 690 695 700Tyr
Ile Lys Thr Lys Pro Ile Val Phe Glu Val Phe Gly His Tyr Gln705 710
715 720Gln His Pro Leu His Leu Gln Gly Gln Glu Leu Asn Ser Pro Pro
Gln 725 730 735Pro Cys Arg Arg Phe Phe Pro Pro Pro Met Pro Leu Ser
Lys Pro Val 740 745 750Pro Ala Thr Lys Leu Asn Thr Met Ser Lys Thr
Ser Leu Gly Gln Ser 755 760 765Met Ser Lys Tyr Asp Leu Leu Val Trp
Phe Glu Ile Ser Glu Leu Glu 770 775 780Pro Thr Gly Glu Tyr Ile Pro
Ala Val Val Asp His Thr Ala Gly Leu785 790 795 800Pro Cys Gln Gly
Thr Phe Leu Leu His Gln Gly Ile Gln Arg Arg Ile 805 810 815Thr Val
Thr Ile Ile His Glu Lys Gly Ser Glu Leu His Trp Lys Asp 820 825
830Val Arg Glu Leu Val Val Gly Arg Ile Arg Asn Lys Pro Glu Val Asp
835 840 845Glu Ala Ala Val Asp Ala Ile Leu Ser Leu Asn Ile Ile Ser
Ala Lys 850 855 860Tyr Leu Lys Ser Ser His Asn Ser Ser Arg Thr Phe
Tyr Arg Phe Glu865 870 875 880Ala Val Trp Asp Ser Ser Leu His Asn
Ser Leu Leu Leu Asn Arg Val 885 890 895Thr Pro Tyr Gly Glu Lys Ile
Tyr Met Thr Leu Ser Ala Tyr Leu Glu 900 905 910Leu Asp His Cys Ile
Gln Pro Ala Val Ile Thr Lys Asp Val Cys Met 915 920 925Val Phe Tyr
Ser Arg Asp Ala Lys Ile Ser Pro Pro Arg Ser Leu Arg 930 935 940Ser
Leu Phe Gly Ser Gly Tyr Ser Lys Ser Pro Asp Ser Asn Arg Val945 950
955 960Thr Gly Ile Tyr Glu Leu Ser Leu Cys Lys Met Ser Asp Thr Gly
Ser 965 970 975Pro Gly Met Gln Arg Arg Arg Arg Lys Ile Leu Asp Thr
Ser Val Ala 980 985 990Tyr Val Arg Gly Glu Glu Asn Leu Ala Gly Trp
Arg Pro Arg Gly Asp 995 1000 1005Ser Leu Ile Leu Glu His Gln Trp
Glu Leu Glu Lys Leu Glu Leu Leu 1010 1015 1020His Glu Val Glu Lys
Thr Arg His Phe Leu Leu Leu Arg Glu Arg Leu1025 1030 1035 1040Gly
Asp Ser Ile Pro Lys Ser Leu Ser Asp Ser Leu Ser Pro Ser Leu 1045
1050 1055Ser Ser Gly Thr Leu Ser Thr Ser Thr Ser Ile Ser Ser Gln
Ile Ser 1060 1065 1070Thr Thr Thr Phe Glu Ser Ala Ile Thr Pro Ser
Glu Ser Ser Gly Tyr 1075 1080 1085Asp Ser Gly Asp Ile Glu Ser Leu
Val Asp Arg Glu Lys Glu Leu Ala 1090 1095 1100Thr Lys Cys Leu Gln
Leu Leu Thr His Thr Phe Asn Arg Glu Phe Ser1105 1110 1115 1120Gln
Val His Gly Ser Val Ser Asp Cys Lys Leu Ser Asp Ile Ser Pro 1125
1130 1135Ile Gly Arg Asp Pro Ser Glu Ser Ser Phe Ser Ser Ala Thr
Leu Thr 1140 1145 1150Pro Ser Ser Thr Cys Pro Ser Leu Val Asp Ser
Arg Ser Asn Ser Leu 1155 1160 1165Asp Gln Lys Thr Pro Glu Ala Asn
Ser Arg Ala Ser Ser Pro Cys Pro 1170 1175 1180Glu Phe Glu Gln Phe
Gln Ile Val Pro Ala Val Glu Thr Pro Tyr Leu1185 1190 1195 1200Ala
Arg Ala Gly Lys Asn Glu Phe Leu Asn Leu Val Pro Asp Ile Glu 1205
1210 1215Glu Ile Arg Pro Ser Ser Val Val Ser Lys Lys Gly Tyr Leu
His Phe 1220 1225 1230Lys Glu Pro Leu Tyr Ser Asn Trp Ala Lys His
Phe Val Val Val Arg 1235 1240 1245Arg Pro Tyr Val Phe Ile Tyr Asn
Ser Asp Lys Asp Pro Val Glu Arg 1250 1255 1260Gly Ile Ile Asn Leu
Ser Thr Ala Gln Val Glu Tyr Ser Glu Asp Gln1265 1270 1275 1280Gln
Ala Met Val Lys Thr Pro Asn Thr Phe Ala Val Cys Thr Lys His 1285
1290 1295Arg Gly Val Leu Leu Gln Ala Leu Asn Asp Lys Asp Met Asn
Asp Trp 1300 1305 1310Leu Tyr Ala Phe Asn Pro Leu Leu Ala Gly Thr
Ile Arg Ser Lys Leu 1315 1320 1325Ser Arg Arg Cys Pro Ser Gln Ser
Lys Tyr 1330 1335313094DNAHomo sapiens 31tttgactggc cgtagagtct
gcgcagttgg tgaatggcgt tggtggcggg aaagttgagt 60ctctcctgcg ccgagccttc
ggggcgatgt gtagtgcctt ccatagggct gagtctggga 120ccgagctcct
tgcccgactt gaaggtagaa gttccttgaa agaaatagaa ccaaatctgt
180ttgctgatga agattcacct gtgcatggtg atattcttga atttcatggc
ccagaaggaa 240caggaaaaac agaaatgctt tatcacctaa cagcacgatg
tatacttccc aaatcagaag 300gtggcctgga agtagaagtc ttatttattg
atacagatta ccactttgat atgctccggc 360tagttacaat tcttgagcac
agactatccc aaagctctga agaaataatc aaatactgcc 420tgggaagatt
ttttttggtg tactgcagta gtagcaccca cttacttctt acactttact
480cactagaaag tatgttttgt agtcacccat ctctctgcct tttgattttg
gatagcctgt 540cagcttttta ctggatagac cgcgtcaatg gaggagaaag
tgtgaactta caggagtcta 600ctctgaggaa atgttctcag tgcttagaga
agcttgtaaa tgactatcgc ctggttcttt 660ttgcaacgac acaaactata
atgcagaaag cctcgagctc atcagaagaa ccttctcatg 720cctctcgacg
actgtgtgat gtggacatag actacagacc ttatctctgt aaggcatggc
780agcaactggt gaagcacagg atgtttttct ccaaacaaga tgattctcaa
agcagcaacc 840aattttcatt agtttcacgt tgtttaaaaa gtaacagttt
aaaaaaacat ttttttatta 900ttggagaaag tggggttgaa ttttgttgat
atacatcata aaatagtctt ttgcagggta 960ctacgcaagc cttaaaattt
ttcttaagac agagtcttgc tctgtctccc aggctggagt 1020gcagtggcac
aatcatggct cactgcagcc ttgaactcct ggcctcaagg gatcctccta
1080tgtgtgcctc ctagagtgca gggattacag gcgtgagcca ctgctcgtgg
ccaaaagttt 1140tctttttttt tttttttctt tttgaaacag tcttactctg
tctcccaggc tgctggagtg 1200cagtggcaca atctcggccc gctgcagcct
ctgcctcttg ggttcaagtg attcttccac 1260ctcagcctcc caggtagctg
ggattacagg cacccaccac cacgcctggc taatttttgt 1320atttttaata
gagacggggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc
1380aagtgatcca cccacctcgg cctcccaaag tgctaggatt acaggcccgt
gcccagccct 1440aaagttttaa actctagggg aattaacagt atttctttac
agaatggatt tgttaaacta 1500gcacagtaaa agtaaagact attctgtttc
taggctgttg aatcaaagtg attttagcaa 1560ttaaactttg tattaattta
ccaccaatat ttcttcacaa aggaactttt aaaagattat 1620ctcagaaagt
aaatctgaga ggtaagaagt aataatgagt aaatggtaag tacttgagta
1680aatctaaaga aatattgata gtaaggcaat cctaagcaaa aagaacaaag
ctggaggcat 1740cacgctaccc agcttcaaac tatactacaa ggctacagta
accaaaacag catagtactg 1800gcacaaaaac acacgtagac tgatggaaca
gaatagagaa tttagaaatg agaccacaca 1860cctataattt ttttgatctt
cgatgaacct gacaaaaaca agcaatgggc aatggattct 1920ctattcaata
aatcgtgctg ggataactgg ccagccatat ggaaaagatt gaaaatggac
1980gccttcctta tgccatatac aaaaattaac tcaagatgga ttaaagactt
aatgtaaaac 2040ccaaaacagt aaaaatcctg gaagacaacc caggcagtac
cattcaggac ataggcacag 2100gcaaagattt catgacgaag acgccaaaaa
caattgcaac agaagcaaaa attcacaaat 2160gggatctaat taaactaaag
agctgcacag caaaagaaac tatcaagaga gtaaacagac 2220agcttacaga
atgggagaaa attgttgcaa actatgcatc tgagaaaggt ctgaaatcca
2280gcatctatac gtaatttaaa caaatttaga agaaaaaacc accccattaa
aaagtgggca 2340aaggacatga acagacactt ttcaaaagaa gacatctgtg
gccaacaatc ctatggaaaa 2400aagcccagca tcactgatca ttagagaaat
gcaaatcgaa acaacaacga gataccatct 2460cacaccagtc caaatggcta
ttataaaaat gtcagaaaat aacagatgct ggtgaggttg 2520tggagaaaaa
gatatgctta tacactgttg gtggaaatgt aaattaaatt agttcagcca
2580ttgtggaaga cagtgtgggg ataaagacag agataccatt caacccagca
atctcattac 2640tgggtatata cccaaaggaa tagaaatcat tgttataaag
acacatgcac gcgtatgttc 2700gttgcagcac tgcccatcag tgacagactg
gattaaaaaa atgtggtaca tacacaccag 2760ggaatactat acagccataa
aaaggaacaa gactgactgg gcgtggtggc tcatgcctgt 2820gatcctagca
ctttgcgagg ccgaggtggg tggattgccc gcgctcagga ggtcaagacc
2880agcctgggca acacggtgaa accccatctc tattaaaata caaaaaatta
gctgggcatg 2940gtggtgcgtg cctgtagtgc cagctactca ggaggccgag
gcaggagaat tgctggaacc 3000caggaggtgg aggttgcagt gagctgagat
cgcgccattg cactcccgcc tgggcgactc 3060catctctaaa aaaaaaaaaa
aaaaaaaaaa aaaa 309432280PRTHomo sapiens 32Met Cys Ser Ala Phe His
Arg Ala Glu Ser Gly Thr Glu Leu Leu Ala 1 5 10 15Arg Leu Glu Gly
Arg Ser Ser Leu Lys Glu Ile Glu Pro Asn Leu Phe 20 25 30Ala Asp Glu
Asp Ser Pro Val His Gly Asp Ile Leu Glu Phe His Gly 35 40 45Pro Glu
Gly Thr Gly Lys Thr Glu Met Leu Tyr His Leu Thr Ala Arg 50 55 60Cys
Ile Leu Pro Lys Ser Glu Gly Gly Leu Glu Val Glu Val Leu Phe65 70 75
80Ile Asp Thr Asp Tyr His Phe Asp Met Leu Arg Leu Val Thr Ile Leu
85 90 95Glu His Arg Leu Ser Gln Ser Ser Glu Glu Ile Ile Lys Tyr Cys
Leu 100 105 110Gly Arg Phe Phe Leu Val Tyr Cys Ser Ser Ser Thr His
Leu Leu Leu 115 120 125Thr Leu Tyr Ser Leu Glu Ser Met Phe Cys Ser
His Pro Ser Leu Cys 130 135 140Leu Leu Ile Leu Asp Ser Leu Ser Ala
Phe Tyr Trp Ile Asp Arg Val145 150 155 160Asn Gly Gly Glu Ser Val
Asn Leu Gln Glu Ser Thr Leu Arg Lys Cys 165 170 175Ser Gln Cys Leu
Glu Lys Leu Val Asn Asp Tyr Arg Leu Val Leu Phe 180 185 190Ala Thr
Thr Gln Thr Ile Met Gln Lys Ala Ser Ser Ser Ser Glu Glu 195 200
205Pro Ser His Ala Ser Arg Arg Leu Cys Asp Val Asp Ile Asp Tyr Arg
210 215 220Pro Tyr Leu Cys Lys Ala Trp Gln Gln Leu Val Lys His Arg
Met Phe225 230 235 240Phe Ser Lys Gln Asp Asp Ser Gln Ser Ser Asn
Gln Phe Ser Leu Val 245 250 255Ser Arg Cys Leu Lys Ser Asn Ser Leu
Lys Lys His Phe Phe Ile Ile 260 265 270Gly Glu Ser Gly Val Glu Phe
Cys 275 28033691DNAHomo sapiens 33gtcctcctcg ccctccaggc cgcccgcgcc
gcgccggagt ccgctgtccg ccagctaccc 60gcttcctgcc gcccgccgct gccatgctgc
ccgccgcgct gctccgccgc ccgggacttg 120gccgcctcgt ccgccacgcc
cgtgcctatg ccgaggccgc cgccgccccg gctgccgcct 180ctggccccaa
ccagatgtcc ttcaccttcg cctctcccac gcaggtgttc ttcaacggtg
240ccaacgtccg gcaggtggac gtgcccacgc tgaccggagc cttcggcatc
ctggcggccc 300acgtgcccac gctgcaggtc ctgcggccgg ggctggtcgt
ggtgcatgca gaggacggca 360ccacctccaa atactttgtg agcagcggtt
ccatcgcagt gaacgccgac tcttcggtgc 420agttgttggc cgaagaggcc
gtgacgctgg acatgttgga cctgggggca gccaaggcaa 480acttggagaa
ggcccaggcg gagctggtgg ggacagctga cgaggccacg cgggcagaga
540tccagatccg aatcgaggcc aacgaggccc tggtgaaggc cctggagtag
gcgagccagc 600cgccaaggtt gacctcagct tcggagccac ctctggatga
actgccccca gcccccgccc 660cattaaagac ccggaagcct gaaaaaaaaa a
69134168PRTHomo sapiens 34Met Leu Pro Ala Ala Leu Leu Arg Arg Pro
Gly Leu Gly Arg Leu Val 1 5 10 15Arg His Ala Arg Ala Tyr Ala Glu
Ala Ala Ala Ala Pro Ala Ala Ala 20 25 30Ser Gly Pro Asn Gln Met Ser
Phe Thr Phe Ala Ser Pro Thr Gln Val 35 40 45Phe Phe Asn Gly Ala Asn
Val Arg Gln Val Asp Val Pro Thr Leu Thr 50 55 60Gly Ala Phe Gly Ile
Leu Ala Ala His Val Pro Thr Leu Gln Val Leu65 70 75 80Arg Pro Gly
Leu Val Val Val His Ala Glu Asp Gly Thr Thr Ser Lys 85 90 95Tyr Phe
Val Ser Ser Gly Ser Ile Ala Val Asn Ala Asp Ser Ser Val 100 105
110Gln Leu Leu Ala Glu Glu Ala Val Thr Leu Asp Met Leu Asp Leu Gly
115 120 125Ala Ala Lys Ala Asn Leu Glu Lys Ala Gln Ala Glu Leu Val
Gly Thr 130 135 140Ala Asp Glu Ala Thr Arg Ala Glu Ile Gln Ile Arg
Ile Glu Ala Asn145 150 155 160Glu Ala Leu Val Lys Ala Leu Glu
165351378DNAHomo sapiens 35gcgcggcccg ctgcaatccg tggaggaacg
cgccgccgag ccaccatcat gcctgggcac 60ttacaggaag gcttcggctg cgtggtcacc
aaccgattcg accagttatt tgacgacgaa 120tcggacccct tcgaggtgct
gaaggcagca gagaacaaga aaaaagaagc cggcgggggc 180ggcgttgggg
gccctggggc caagagcgca gctcaggccg cggcccagac caactccaac
240gcggcaggca aacagctgcg caaggagtcc cagaaagacc gcaagaaccc
gctgcccccc 300agcgttggcg tggttgacaa gaaagaggag acgcagccgc
ccgtggcgct taagaaagaa 360ggaataagac gagttggaag aagacctgat
caacaacttc agggtgaagg gaaaataatt 420gatagaagac cagaaaggcg
accacctcgt gaacgaagat tcgaaaagcc acttgaagaa 480aagggtgaag
gaggcgaatt ttcagttgat agaccgatta ttgaccgacc tattcgaggt
540cgtggtggtc ttggaagagg tcgagggggc cgtggacgtg gaatgggccg
aggagatgga 600tttgattctc gtggcaaacg tgaatttgat aggcatagtg
gaagtgatag atcttctttt 660tcacattaca gtggcctgaa gcacgaggac
aaacgtggag gtagcggatc tcacaactgg 720ggaactgtca aagacgaatt
aacagagtcc cccaaataca ttcagaaaca aatatcttat 780aattacagtg
acttggatca atcaaatgtg actgaggaaa cacctgaagg tgaagaacat
840catccagtgg cagacactga aaataaggag aatgaagttg aagaggtaaa
agaggagggt 900ccaaaagaga tgactttgga tgagtggaag gctattcaaa
ataaggaccg ggcaaaagta 960gaatttaata tccgaaaacc aaatgaaggt
gctgatgggc agtggaagaa gggatttgtt 1020cttcataaat caaagagtga
agaggctcat gctgaagatt cggttatgga ccatcatttc 1080cggaagccag
caaatgatat aacgtctcag ctggagatca attttggaga ccttggccgc
1140ccaggacgtg gcggcagggg aggacgaggt ggacgtgggc gtggtgggcg
cccaaaccgt 1200ggcagcagga ccgacaagtc aagtgcttct gctcctgatg
tggatgaccc agaggcattc 1260ccagctctgg cttaactgga tgccataaga
caaccctggt tcctttgtga acccttctgt 1320tcaaagcttt tgcatgctta
aggattccaa acgactaaga aaaaaaaaaa aaaaaaaa 1378362896DNAHomo sapiens
36gggcgcgcca gctcgtagca ggggagcgcc cgcggcgtcg ggtttgggct ggaggtcgcc
60atggggcgag gcagcggcac cttcgagcgt ctcctagaca aggcgaccag ccagctcctg
120ttggagacag attgggagtc cattttgcag atctgcgacc tgatccgcca
aggggacaca 180caagcaaaat atgctgtgaa ttccatcaag aagaaagtca
acgacaagaa cccacacgtc 240gccttgtatg ccctggaggt catggaatct
gtggtaaaga actgtggcca gacagttcat 300gatgaggtgg ccaacaagca
gaccatggag gagctgaagg acctgctgaa gagacaagtg 360gaggtaaacg
tccgtaacaa gatcctgtac ctgatccagg cctgggcgca tgccttccgg
420aacgagccca agtacaaggt ggtccaggac acctaccaga tcatgaaggt
ggaggggcac 480gtctttccag aattcaaaga gagcgatgcc atgtttgctg
ccgagagagc cccagactgg 540gtggacgctg aggaatgcca ccgctgcagg
gtgcagttcg gggtgatgac ccgtaagcac 600cactgccggg cgtgtgggca
gatattctgt ggaaagtgtt cttccaagta ctccaccatc 660cccaagtttg
gcatcgagaa ggaggtgcgc gtgtgtgagc cctgctacga gcagctgaac
720aggaaagcgg agggaaaggc cacttccacc actgagctgc cccccgagta
cctgaccagc 780cccctgtctc agcagtccca gctgcccccc aagagggacg
agacggccct gcaggaggag 840gaggagctgc agctggccct ggcgctgtca
cagtcagagg cggaggagaa ggagaggctg 900agacagaagt ccacgtacac
ttcgtacccc aaggcggagc ccatgccctc ggcctcctca 960gcgccccccg
ccagcagcct gtactcttca cctgtgaact cgtcggcgcc tctggctgag
1020gacatcgacc ctgagctcgc acggtatctc aaccggaact actgggagaa
gaagcaggag 1080gaggctcgca agagccccac gccatctgcg cccgtgcccc
tgacggagcc ggctgcacag 1140cctggggaag ggcacgcagc ccccaccaac
gtggtggaga accccctccc ggagacagac 1200tctcagccca ttcctccctc
tggtggcccc tttagtgagc cacagttcca caatggcgag 1260tctgaggaga
gccacgagca gttcctgaag gcgctgcaga acgccgtcac caccttcgtg
1320aaccgcatga agagtaacca catgcggggc cgcagcatca ccaatgactc
ggccgtgctc 1380tcactcttcc agtccatcaa cggcatgcac ccgcagctgc
tggagctgct caaccagctg 1440gacgagcgca ggctgtacta tgaggggctg
caggacaagc tggcacagat ccgcgatgcc 1500cggggggcgc tgagtgccct
gcgcgaagag caccgggaga agcttcgccg ggcagccgag 1560gaggcagagc
gccagcgcca gatccagctg gcccagaagc tggagataat gcggcagaag
1620aagcaggagt acctggaggt gcagaggcag ctggccatcc agcgcctgca
ggagcaggag 1680aaggagcggc agatgcggct ggagcagcag aagcagacgg
tccagatgcg cgcgcagatg 1740cccgccttcc ccctgcccta cgcccagctc
caggccatgc ccgcagccgg aggtgtgctc 1800taccagccct cgggaccagc
cagcttcccc agcaccttca gccctgccgg ctcggtggag 1860ggctccccaa
tgcacggcgt gtacatgagc cagccggccc ctgccgctgg cccctacccc
1920agcatgccca gcactgcggc tgatcccagc atggtgagtg cctacatgta
cccagcaggg 1980gccactgggg cgcaggcggc cccccaggcc caggccggac
ccaccgccag ccccgcttac 2040tcatcctacc agcctactcc cacagcgggc
taccagaacg
tggcctccca ggccccacag 2100agcctcccgg ccatctctca gcctccgcag
tccagcacca tgggctacat ggggagccag 2160tcagtctcca tgggctacca
gccttacaac atgcagaatc tcatgaccac cctcccaagc 2220caggatgcgt
ctctgccacc ccagcagccc tacatcgcgg ggcagcagcc catgtaccag
2280cagatggcac cctctggcgg tcccccccag cagcagcccc ccgtggccca
gcaaccgcag 2340gcacaggggc cgccggcaca gggcagcgag gcccagctca
tttcattcga ctgacccagg 2400ccatgctcac gtccggagta acactacata
cagttcacct gaaacgcctc gtctctaact 2460gccgtcgtcc tgcctccctg
tcctctactg ccggtagtgt cccttctctg cgagtgaggg 2520ggggccttca
ccccaagccc acctcccttg tcctcagcct actgcagtcc ctgagttagt
2580ctctgctttc tttccccagg gctgggccat ggggagggaa ggactttctc
ccaggggaag 2640cccccagccc tgtgggtcat ggtctgtgag aggtggcagg
aatggggacc ctcacccccc 2700aagcagcctg tgccctctgg ccgcactgtg
agctggctgt ggtgtctggg tgtggcctgg 2760ggctccctct gcaggggcct
ctctcggcag ccacagccaa gggtggaggc ttcaggtctc 2820cagcttctct
gcttctcagc tgccatctcc agtgccccag aatggtacag cgataataaa
2880atgtatttca gaaagg 289637777PRTHomo sapiens 37Met Gly Arg Gly
Ser Gly Thr Phe Glu Arg Leu Leu Asp Lys Ala Thr 1 5 10 15Ser Gln
Leu Leu Leu Glu Thr Asp Trp Glu Ser Ile Leu Gln Ile Cys 20 25 30Asp
Leu Ile Arg Gln Gly Asp Thr Gln Ala Lys Tyr Ala Val Asn Ser 35 40
45Ile Lys Lys Lys Val Asn Asp Lys Asn Pro His Val Ala Leu Tyr Ala
50 55 60Leu Glu Val Met Glu Ser Val Val Lys Asn Cys Gly Gln Thr Val
His65 70 75 80Asp Glu Val Ala Asn Lys Gln Thr Met Glu Glu Leu Lys
Asp Leu Leu 85 90 95Lys Arg Gln Val Glu Val Asn Val Arg Asn Lys Ile
Leu Tyr Leu Ile 100 105 110Gln Ala Trp Ala His Ala Phe Arg Asn Glu
Pro Lys Tyr Lys Val Val 115 120 125Gln Asp Thr Tyr Gln Ile Met Lys
Val Glu Gly His Val Phe Pro Glu 130 135 140Phe Lys Glu Ser Asp Ala
Met Phe Ala Ala Glu Arg Ala Pro Asp Trp145 150 155 160Val Asp Ala
Glu Glu Cys His Arg Cys Arg Val Gln Phe Gly Val Met 165 170 175Thr
Arg Lys His His Cys Arg Ala Cys Gly Gln Ile Phe Cys Gly Lys 180 185
190Cys Ser Ser Lys Tyr Ser Thr Ile Pro Lys Phe Gly Ile Glu Lys Glu
195 200 205Val Arg Val Cys Glu Pro Cys Tyr Glu Gln Leu Asn Arg Lys
Ala Glu 210 215 220Gly Lys Ala Thr Ser Thr Thr Glu Leu Pro Pro Glu
Tyr Leu Thr Ser225 230 235 240Pro Leu Ser Gln Gln Ser Gln Leu Pro
Pro Lys Arg Asp Glu Thr Ala 245 250 255Leu Gln Glu Glu Glu Glu Leu
Gln Leu Ala Leu Ala Leu Ser Gln Ser 260 265 270Glu Ala Glu Glu Lys
Glu Arg Leu Arg Gln Lys Ser Thr Tyr Thr Ser 275 280 285Tyr Pro Lys
Ala Glu Pro Met Pro Ser Ala Ser Ser Ala Pro Pro Ala 290 295 300Ser
Ser Leu Tyr Ser Ser Pro Val Asn Ser Ser Ala Pro Leu Ala Glu305 310
315 320Asp Ile Asp Pro Glu Leu Ala Arg Tyr Leu Asn Arg Asn Tyr Trp
Glu 325 330 335Lys Lys Gln Glu Glu Ala Arg Lys Ser Pro Thr Pro Ser
Ala Pro Val 340 345 350Pro Leu Thr Glu Pro Ala Ala Gln Pro Gly Glu
Gly His Ala Ala Pro 355 360 365Thr Asn Val Val Glu Asn Pro Leu Pro
Glu Thr Asp Ser Gln Pro Ile 370 375 380Pro Pro Ser Gly Gly Pro Phe
Ser Glu Pro Gln Phe His Asn Gly Glu385 390 395 400Ser Glu Glu Ser
His Glu Gln Phe Leu Lys Ala Leu Gln Asn Ala Val 405 410 415Thr Thr
Phe Val Asn Arg Met Lys Ser Asn His Met Arg Gly Arg Ser 420 425
430Ile Thr Asn Asp Ser Ala Val Leu Ser Leu Phe Gln Ser Ile Asn Gly
435 440 445Met His Pro Gln Leu Leu Glu Leu Leu Asn Gln Leu Asp Glu
Arg Arg 450 455 460Leu Tyr Tyr Glu Gly Leu Gln Asp Lys Leu Ala Gln
Ile Arg Asp Ala465 470 475 480Arg Gly Ala Leu Ser Ala Leu Arg Glu
Glu His Arg Glu Lys Leu Arg 485 490 495Arg Ala Ala Glu Glu Ala Glu
Arg Gln Arg Gln Ile Gln Leu Ala Gln 500 505 510Lys Leu Glu Ile Met
Arg Gln Lys Lys Gln Glu Tyr Leu Glu Val Gln 515 520 525Arg Gln Leu
Ala Ile Gln Arg Leu Gln Glu Gln Glu Lys Glu Arg Gln 530 535 540Met
Arg Leu Glu Gln Gln Lys Gln Thr Val Gln Met Arg Ala Gln Met545 550
555 560Pro Ala Phe Pro Leu Pro Tyr Ala Gln Leu Gln Ala Met Pro Ala
Ala 565 570 575Gly Gly Val Leu Tyr Gln Pro Ser Gly Pro Ala Ser Phe
Pro Ser Thr 580 585 590Phe Ser Pro Ala Gly Ser Val Glu Gly Ser Pro
Met His Gly Val Tyr 595 600 605Met Ser Gln Pro Ala Pro Ala Ala Gly
Pro Tyr Pro Ser Met Pro Ser 610 615 620Thr Ala Ala Asp Pro Ser Met
Val Ser Ala Tyr Met Tyr Pro Ala Gly625 630 635 640Ala Thr Gly Ala
Gln Ala Ala Pro Gln Ala Gln Ala Gly Pro Thr Ala 645 650 655Ser Pro
Ala Tyr Ser Ser Tyr Gln Pro Thr Pro Thr Ala Gly Tyr Gln 660 665
670Asn Val Ala Ser Gln Ala Pro Gln Ser Leu Pro Ala Ile Ser Gln Pro
675 680 685Pro Gln Ser Ser Thr Met Gly Tyr Met Gly Ser Gln Ser Val
Ser Met 690 695 700Gly Tyr Gln Pro Tyr Asn Met Gln Asn Leu Met Thr
Thr Leu Pro Ser705 710 715 720Gln Asp Ala Ser Leu Pro Pro Gln Gln
Pro Tyr Ile Ala Gly Gln Gln 725 730 735Pro Met Tyr Gln Gln Met Ala
Pro Ser Gly Gly Pro Pro Gln Gln Gln 740 745 750Pro Pro Val Ala Gln
Gln Pro Gln Ala Gln Gly Pro Pro Ala Gln Gly 755 760 765Ser Glu Ala
Gln Leu Ile Ser Phe Asp 770 775382569DNAHomo sapiens 38tccctcgtct
ctctcgggca acatggcggg cgtggaggag gtagcggcct ccgggagcca 60cctgaatggc
gacctggatc cagacgacag ggaagaagga gctgcctcta cggctgagga
120agcagccaag aaaaaaagac gaaagaagaa gaagagcaaa gggccttctg
cagcagggga 180acaggaacct gataaagaat caggagcctc agtggatgaa
gtagcaagac agttggaaag 240atcagcattg gaagataaag aaagagatga
agatgatgaa gatggagatg gcgatggaga 300tggagcaact ggaaagaaga
agaaaaagaa gaagaagaag agaggaccaa aagttcaaac 360agaccctccc
tcagttccaa tatgtgacct gtatcctaat ggtgtatttc ccaaaggaca
420agaatgcgaa tacccaccca cacaagatgg gcgaacagct gcttggagaa
ctacaagtga 480agaaaagaaa gcattagatc aggcaagtga agagatttgg
aatgattttc gagaagctgc 540agaagcacat cgacaagtta gaaaatacgt
aatgagctgg atcaagcctg ggatgacaat 600gatagaaatc tgtgaaaagt
tggaagactg ttcacgcaag ttaataaaag agaatggatt 660aaatgcaggc
ctggcatttc ctactggatg ttctctcaat aattgtgctg cccattatac
720tcccaatgcc ggtgacacaa cagtattaca gtatgatgac atctgtaaaa
tagactttgg 780aacacatata agtggtagga ttattgactg tgcttttact
gtcactttta atcccaaata 840tgatacgtta ttaaaagctg taaaagatgc
tactaacact ggaataaagt gtgctggaat 900tgatgttcgt ctgtgtgatg
ttggtgaggc catccaagaa gttatggagt cctatgaagt 960tgaaatagat
gggaagacat atcaagtgaa accaatccgt aatctaaatg gacattcaat
1020tgggcaatat agaatacatg ctggaaaaac agtgccgatt gtgaaaggag
gggaggcaac 1080aagaatggag gaaggagaag tatatgcaat tgaaaccttt
ggtagtacag gaaaaggtgt 1140tgttcatgat gatatggaat gttcacatta
catgaaaaat tttgatgttg gacatgtgcc 1200aataaggctt ccaagaacaa
aacacttgtt aaatgtcatc aatgaaaact ttggaaccct 1260tgccttctgc
cgcagatggc tggatcgctt gggagaaagt aaatacttga tggctctgaa
1320gaatctgtgt gacttgggca ttgtagatcc atatccacca ttatgtgaca
ttaaaggatc 1380atatacagcg caatttgaac ataccatcct gttgcgtcca
acatgtaaag aagttgtcag 1440cagaggagat gactattaaa cttagtccaa
agccacctca acacctttat tttctgagct 1500ttgttggaaa acatgatacc
agaattaatt tgccacatgt tgtctgtttt aacagtggac 1560ccatgtaata
cttttatcca tgtttaaaaa agaaggaatt tggacaaagg caaaccgtct
1620aatgtaatta accaacgaaa aagctttccg gacttttaaa tgctaactgt
ttttcccctt 1680cctgtctagg aaaatgctat aaagctcaaa ttagttagga
atgacttata cgttttgttt 1740tgaataccta agagatactt tttggatatt
tatattgcca tattcttact tgaatgcttt 1800gaatgactac atccagttct
gcacctatac cctctggtgt tgctttttaa ccttcctgga 1860atccattttc
taaaaaataa agacacattc ttctcagcac cacacaacac ctattccaaa
1920atcgaccaca tatttggaag taaagctctc ctcagcaaat gtaaaagaac
agaaattata 1980acaaactgtc tctcagacca cagtataacc aaactagaac
tcaggattaa gaaactcact 2040caaaaccaca caactacatg gaaactgaac
aacctgctcc tgaatgacta ctggatacat 2100aacaaaatga aggcagaaat
aaagatgttc tttaaaacca atgagaacaa agacacaaca 2160taccagaatc
tctgggacac attcaaagca gtgtgtagag ggaaatttat agcactaaat
2220gcccacaaga gaaagcagga aatatctaaa attgacaccc taacatcaca
attaaaagaa 2280ctagagaagc aagagcaaac acattgaaaa gctaagagaa
ggcaagaaat aactaagatc 2340agagcagaac tgaaggaaat agagacacaa
aaaactcttc aaaaaatcaa tgaatccagg 2400agctggtttt ttgaaacgat
caacaaaatt gatagacact agcaagacta ataaagaaga 2460aaggagagaa
gaatcaaata gaagcaataa aaaatgataa aggggatatc accaccaatc
2520ccacagaaat aaaccaccat cagagaatac tacaaacacc tctacgcaa
256939478PRTHomo sapiens 39Met Ala Gly Val Glu Glu Val Ala Ala Ser
Gly Ser His Leu Asn Gly 1 5 10 15Asp Leu Asp Pro Asp Asp Arg Glu
Glu Gly Ala Ala Ser Thr Ala Glu 20 25 30Glu Ala Ala Lys Lys Lys Arg
Arg Lys Lys Lys Lys Ser Lys Gly Pro 35 40 45Ser Ala Ala Gly Glu Gln
Glu Pro Asp Lys Glu Ser Gly Ala Ser Val 50 55 60Asp Glu Val Ala Arg
Gln Leu Glu Arg Ser Ala Leu Glu Asp Lys Glu65 70 75 80Arg Asp Glu
Asp Asp Glu Asp Gly Asp Gly Asp Gly Asp Gly Ala Thr 85 90 95Gly Lys
Lys Lys Lys Lys Lys Lys Lys Lys Arg Gly Pro Lys Val Gln 100 105
110Thr Asp Pro Pro Ser Val Pro Ile Cys Asp Leu Tyr Pro Asn Gly Val
115 120 125Phe Pro Lys Gly Gln Glu Cys Glu Tyr Pro Pro Thr Gln Asp
Gly Arg 130 135 140Thr Ala Ala Trp Arg Thr Thr Ser Glu Glu Lys Lys
Ala Leu Asp Gln145 150 155 160Ala Ser Glu Glu Ile Trp Asn Asp Phe
Arg Glu Ala Ala Glu Ala His 165 170 175Arg Gln Val Arg Lys Tyr Val
Met Ser Trp Ile Lys Pro Gly Met Thr 180 185 190Met Ile Glu Ile Cys
Glu Lys Leu Glu Asp Cys Ser Arg Lys Leu Ile 195 200 205Lys Glu Asn
Gly Leu Asn Ala Gly Leu Ala Phe Pro Thr Gly Cys Ser 210 215 220Leu
Asn Asn Cys Ala Ala His Tyr Thr Pro Asn Ala Gly Asp Thr Thr225 230
235 240Val Leu Gln Tyr Asp Asp Ile Cys Lys Ile Asp Phe Gly Thr His
Ile 245 250 255Ser Gly Arg Ile Ile Asp Cys Ala Phe Thr Val Thr Phe
Asn Pro Lys 260 265 270Tyr Asp Thr Leu Leu Lys Ala Val Lys Asp Ala
Thr Asn Thr Gly Ile 275 280 285Lys Cys Ala Gly Ile Asp Val Arg Leu
Cys Asp Val Gly Glu Ala Ile 290 295 300Gln Glu Val Met Glu Ser Tyr
Glu Val Glu Ile Asp Gly Lys Thr Tyr305 310 315 320Gln Val Lys Pro
Ile Arg Asn Leu Asn Gly His Ser Ile Gly Gln Tyr 325 330 335Arg Ile
His Ala Gly Lys Thr Val Pro Ile Val Lys Gly Gly Glu Ala 340 345
350Thr Arg Met Glu Glu Gly Glu Val Tyr Ala Ile Glu Thr Phe Gly Ser
355 360 365Thr Gly Lys Gly Val Val His Asp Asp Met Glu Cys Ser His
Tyr Met 370 375 380Lys Asn Phe Asp Val Gly His Val Pro Ile Arg Leu
Pro Arg Thr Lys385 390 395 400His Leu Leu Asn Val Ile Asn Glu Asn
Phe Gly Thr Leu Ala Phe Cys 405 410 415Arg Arg Trp Leu Asp Arg Leu
Gly Glu Ser Lys Tyr Leu Met Ala Leu 420 425 430Lys Asn Leu Cys Asp
Leu Gly Ile Val Asp Pro Tyr Pro Pro Leu Cys 435 440 445Asp Ile Lys
Gly Ser Tyr Thr Ala Gln Phe Glu His Thr Ile Leu Leu 450 455 460Arg
Pro Thr Cys Lys Glu Val Val Ser Arg Gly Asp Asp Tyr465 470
475401183DNAHomo sapiensmisc_feature(0)...(0)n = a, t, c or g
40cgcccaagaa gaaaatggcc ataagtggag tccctgtgct aggatttttc atcatagctg
60tgctgatgag cgctcaggaa tcatgggcta tcaaagaaga acatgtgatc atccaggccg
120agttctatct gaatcctgac caatcaggcg agtttatgtt tgactttgat
ggtgatgaga 180ttttccatgt ggatatggca aagaaggaga cggtctggcg
gcttgaagaa tttggacgat 240ttgccagctt tgaggctcaa ggtgcattgg
ccaacatagc tgtggacaaa gccaacttgg 300aaatcatgac aaagcgctcc
aactatactc cgatcaccaa tgtacctcca gaggtaactg 360tgctcacgaa
cagccctgtg gaactgagag agcccaacgt cctcatctgt ttcatcgaca
420agttcacccc accagtggtc aatgtcacgt ggcttcgaaa tggaaaacct
gtcaccacag 480gagtgtcaga gacagtcttc ctgcccaggg aagaccacct
tttccgcaag ttccactatc 540tccccttcct gccctcaact gaggacgttt
acgactgcag ggtggagcac tggggcttgg 600atgagcctct tctcaagcac
tgggagtttg atgctccaag ccctctccca gagactacag 660agaacgtggt
gtgtgccctg ggcctgactg tgggtctggt gggcatcatt attgggacca
720tcttcatcat caagggagtg cgcaaaagca atgcagcaga acgcaggggg
cctctgtaag 780gcacatggag gtgatgatgt ttcttagaga gaagatcact
gaagaaactt ctgctttaat 840gactttacaa agctggcaat attacaatcc
ttgacctcag tgaaagcagt catcttcagc 900gttttccagc cctatagcca
ccccaagtgt ggttatgcct cctcgattgc tccgtactct 960aacatctagc
tggcttccct gtctattgcc ttttcctgta tctattttcc tctatttcct
1020atcattttat tatcaccatg caatgcctct ggaataaaac atacaggagt
ctgtctctgc 1080tatggaatgc cccatggggc atctcttgtg tacttattgt
ttaaggtttc ctcaaactgn 1140gattcttctg aacacaataa actattttga
tgatcttggg tgg 118341254PRTHomo sapiens 41Met Ala Ile Ser Gly Val
Pro Val Leu Gly Phe Phe Ile Ile Ala Val 1 5 10 15Leu Met Ser Ala
Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 20 25 30Ile Gln Ala
Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 35 40 45Phe Asp
Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 50 55 60Glu
Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu65 70 75
80Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu
85 90 95Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro
Pro 100 105 110Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg
Glu Pro Asn 115 120 125Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro
Pro Val Val Asn Val 130 135 140Thr Trp Leu Arg Asn Gly Lys Pro Val
Thr Thr Gly Val Ser Glu Thr145 150 155 160Val Phe Leu Pro Arg Glu
Asp His Leu Phe Arg Lys Phe His Tyr Leu 165 170 175Pro Phe Leu Pro
Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 180 185 190Trp Gly
Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 195 200
205Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu
210 215 220Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile
Ile Lys225 230 235 240Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg
Gly Pro Leu 245 25042266DNAHomo sapiens 42atgcccaagt gtcccaagtg
caacaaggag gtgtacttcg ccgagagggt gacctctctg 60ggcaaggact ggcatcggcc
ctgcctgaag tgcgagaaat gtgggaagac gctgacctct 120gggggccacg
ctgagcacga aggcaaaccc tactgcaacc acccctgcta cgcagccatg
180tttgggccta aaggctttgg gcggggcgga gccgagagcc acactttcaa
gtaaaccagg 240tggtggagac ccatccttgg ctgctt 2664377PRTHomo sapiens
43Met Pro Lys Cys Pro Lys Cys Asn Lys Glu Val Tyr Phe Ala Glu Arg 1
5 10 15Val Thr Ser Leu Gly Lys Asp Trp His Arg Pro Cys Leu Lys Cys
Glu 20 25 30Lys Cys Gly Lys Thr Leu Thr Ser Gly Gly His Ala Glu His
Glu Gly 35 40 45Lys Pro Tyr Cys Asn His Pro Cys Tyr Ala Ala Met Phe
Gly Pro Lys 50 55 60Gly Phe Gly Arg Gly Gly Ala Glu Ser His Thr Phe
Lys65 70 75441665DNAHomo sapiens 44gaaggaactg gttctgctca cacttgctgg
cttgcgcatc aggactggct ttatctcctg 60actcacggtg caaaggtgca ctctgcgaac
gttaagtccg tccccagcgc ttggaatcct 120acggccccca cagccggatc
ccctcagcct tccaggtcct caactcccgt ggacgctgaa 180caatggcctc
catggggcta caggtaatgg gcatcgcgct ggccgtcctg ggctggctgg
240ccgtcatgct gtgctgcgcg ctgcccatgt ggcgcgtgac ggccttcatc
ggcagcaaca 300ttgtcacctc gcagaccatc tgggagggcc tatggatgaa
ctgcgtggtg cagagcaccg 360gccagatgca gtgcaaggtg tacgactcgc
tgctggcact gccgcaggac ctgcaggcgg 420cccgcgccct cgtcatcatc
agcatcatcg tggctgctct gggcgtgctg ctgtccgtgg 480tggggggcaa
gtgtaccaac tgcctggagg atgaaagcgc caaggccaag accatgatcg
540tggcgggcgt ggtgttcctg ttggccggcc ttatggtgat agtgccggtg
tcctggacgg 600cccacaacat catccaagac ttctacaatc cgctggtggc
ctccgggcag aagcgggaga 660tgggtgcctc gctctacgtc ggctgggccg
cctccggcct gctgctcctt ggcggggggc 720tgctttgctg caactgtcca
ccccgcacag acaagcctta ctccgccaag tattctgctg 780cccgctctgc
tgctgccagc aactacgtgt aaggtgccac ggctccactc tgttcctctc
840tgctttgttc ttccctggac tgagctcagc gcaggctgtg accccaggag
ggccctgcca 900cgggccactg gctgctgggg actggggact gggcagagac
tgagccaggc aggaaggcag 960cagccttcag cctctctggc ccactcggac
aacttcccaa ggccgcctcc tgctagcaag 1020aacagagtcc accctcctct
ggatattggg gagggacgga agtgacaggg tgtggtggtg 1080gagtggggag
ctggcttctg ctggccagga tagcttaacc ctgactttgg gatctgcctg
1140catcggcgtt ggccactgtc cccatttaca ttttccccac tctgtctgcc
tgcatctcct 1200ctgttccggg taggccttga tatcacctct gggactgtgc
cttgctcacc gaaacccgcg 1260cccaggagta tggctgaggc cttgcccacc
cacctgcctg ggaagtgcag agtggatgga 1320cgggtttaga ggggaggggc
gaaggtgctg taaacaggtt tgggcagtgg tgggggaggg 1380ggccagagag
gcggctcagg ttgcccagct ctgtggcctc aggactctct gcctcacccg
1440cttcagccca gggcccctgg agactgatcc cctctgagtc ctctgcccct
tccaaggaca 1500ctaatgagcc tgggagggtg gcagggagga ggggacagct
tcacccttgg aagtcctggg 1560gtttttcctc ttccttcttt gtggtttctg
ttttgtaatt taagaagagc tattcatcac 1620tgtaattatt attattttct
acaataaatg ggacctgtgc acagg 166545209PRTHomo sapiens 45Met Ala Ser
Met Gly Leu Gln Val Met Gly Ile Ala Leu Ala Val Leu 1 5 10 15Gly
Trp Leu Ala Val Met Leu Cys Cys Ala Leu Pro Met Trp Arg Val 20 25
30Thr Ala Phe Ile Gly Ser Asn Ile Val Thr Ser Gln Thr Ile Trp Glu
35 40 45Gly Leu Trp Met Asn Cys Val Val Gln Ser Thr Gly Gln Met Gln
Cys 50 55 60Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln
Ala Ala65 70 75 80Arg Ala Leu Val Ile Ile Ser Ile Ile Val Ala Ala
Leu Gly Val Leu 85 90 95Leu Ser Val Val Gly Gly Lys Cys Thr Asn Cys
Leu Glu Asp Glu Ser 100 105 110Ala Lys Ala Lys Thr Met Ile Val Ala
Gly Val Val Phe Leu Leu Ala 115 120 125Gly Leu Met Val Ile Val Pro
Val Ser Trp Thr Ala His Asn Ile Ile 130 135 140Gln Asp Phe Tyr Asn
Pro Leu Val Ala Ser Gly Gln Lys Arg Glu Met145 150 155 160Gly Ala
Ser Leu Tyr Val Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 165 170
175Gly Gly Gly Leu Leu Cys Cys Asn Cys Pro Pro Arg Thr Asp Lys Pro
180 185 190Tyr Ser Ala Lys Tyr Ser Ala Ala Arg Ser Ala Ala Ala Ser
Asn Tyr 195 200 205Val461009DNAHomo sapiens 46ggcagtagct tgctgatgct
cccagctgaa taaagccctt ccttctacaa tttggtgtct 60gaggggtttt gtctgcggct
cgtcctgcta catttcttgg ttccctgacc aggaaacgag 120gtaactgatg
gacagccgag gcagcccctt aggcggctta ggcctcccct gtggagcatc
180cctgaggcgg actccggcca gcccgagtga tgcgatccaa agagcactcc
cgggtaggaa 240attgccccgg tggaatgcct caccagagca gcgtgtagca
gttccctgtg gaggattaac 300acagtggctg aacaccggga aggaactggc
acttggagtc cggacatctg aaacttggta 360agactagtct ttggaacttg
ccccactcca tctaggtgga agtgtggcct gatcacccac 420gacatgcctg
cattggcact tctgttctgg ttttgacttg acttagattg tgtgatactt
480tggttttggt tttggtttga cctggcttgg attctagata ctctgatttg
gttttgattt 540tggtttggtg taaactgcaa gagtgtgtat gcccttttta
cctgtttttt tgtttgtggc 600atgtgtgtgg tgtgggtgtg gtgttttgtc
tcgaagaagc atgggtcagg tacaaataag 660cccaccccac taggaactat
gttaaaaaaa aattcaagaa agaatttaag ggagattaca 720gtgttactgt
gacaccagga aaacttagaa ctttgtgtga aatagactgg ccagcattag
780aggtgggttg gccatcagaa ggaagcctgg acaggtccct tgtttcaaag
gtatgacaca 840aggtaacacc aattctaagt taatttgaag tttgcttaaa
gttaacagtg taacatgtat 900tatggtaact tctaatcttg tggccttaga
cagtctagtc caaaggcata aagaaagttt 960gctttaaaaa aaaaaaaaag
gaatggttat cttcaaaaaa aaaaaaaaa 1009471250DNAHomo sapiens
47aattcggcac gagggcaggt gcaggcgcac gcggcgagag cgtatggagc cgagccgtta
60gcgcgcgccg tcggtgagtc agtccgtccg tccgtccgtc cgtcggggcg ccgcagctcc
120cgccaggccc agcggccccg gcccctcgtc tccccgcacc cggagccacc
cggtggagcg 180ggccttgccg cggcagccat gtccatgggc ctggagatca
cgggcaccgc gctggccgtg 240ctgggctggc tgggcaccat cgtgtgctgc
gcgttgccca tgtggcgcgt gtcggccttc 300atcggcagca acatcatcac
gtcgcagaac atctgggagg gcctgtggat gaactgcgtg 360gtgcagagca
ccggccagat gcagtgcaag gtgtacgact cgctgctggc actgccacag
420gaccttcagg cggcccgcgc cctcatcgtg gtggccatcc tgctggccgc
cttcgggctg 480ctagtggcgc tggtgggcgc ccagtgcacc aactgcgtgc
aggacgacac ggccaaggcc 540aagatcacca tcgtggcagg cgtgctgttc
cttctcgccg ccctgctcac cctcgtgccg 600gtgtcctggt cggccaacac
cattatccgg gacttctaca accccgtggt gcccgaggcg 660cagaagcgcg
agatgggcgc gggcctgtac gtgggctggg cggccgcggc gctgcagctg
720ctggggggcg cgctgctctg ctgctcgtgt cccccacgcg agaagaagta
cacggccacc 780aaggtcgtct actccgcgcc gcgctccacc ggcccgggag
ccagcctggg cacaggctac 840gaccgcaagg actacgtcta agggacagac
gcagggagac cccaccacca ccaccaccac 900caacaccacc accaccaccg
cgagctggag cgcgcaccag gccatccagc gtgcagcctt 960gcctcggagg
ccagcccacc cccagaagcc aggaagcccc cgcgctggac tggggcagct
1020tccccagcag ccacggcttt gcgggccggg cagtcgactt cggggcccag
ggaccaacct 1080gcatggactg tgaaacctca cccttctgga gcacggggcc
tgggtgaccg ccaatacttg 1140accaccccgt cgagccccat cgggccgctg
cccccatgtc gcgctgggca gggaccggca 1200gccctggaag gggcacttga
tatttttcaa taaaagcctc tcgttttagc 125048220PRTHomo sapiens 48Met Ser
Met Gly Leu Glu Ile Thr Gly Thr Ala Leu Ala Val Leu Gly 1 5 10
15Trp Leu Gly Thr Ile Val Cys Cys Ala Leu Pro Met Trp Arg Val Ser
20 25 30Ala Phe Ile Gly Ser Asn Ile Ile Thr Ser Gln Asn Ile Trp Glu
Gly 35 40 45Leu Trp Met Asn Cys Val Val Gln Ser Thr Gly Gln Met Gln
Cys Lys 50 55 60Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln
Ala Ala Arg65 70 75 80Ala Leu Ile Val Val Ala Ile Leu Leu Ala Ala
Phe Gly Leu Leu Val 85 90 95Ala Leu Val Gly Ala Gln Cys Thr Asn Cys
Val Gln Asp Asp Thr Ala 100 105 110Lys Ala Lys Ile Thr Ile Val Ala
Gly Val Leu Phe Leu Leu Ala Ala 115 120 125Leu Leu Thr Leu Val Pro
Val Ser Trp Ser Ala Asn Thr Ile Ile Arg 130 135 140Asp Phe Tyr Asn
Pro Val Val Pro Glu Ala Gln Lys Arg Glu Met Gly145 150 155 160Ala
Gly Leu Tyr Val Gly Trp Ala Ala Ala Ala Leu Gln Leu Leu Gly 165 170
175Gly Ala Leu Leu Cys Cys Ser Cys Pro Pro Arg Glu Lys Lys Tyr Thr
180 185 190Ala Thr Lys Val Val Tyr Ser Ala Pro Arg Ser Thr Gly Pro
Gly Ala 195 200 205Ser Leu Gly Thr Gly Tyr Asp Arg Lys Asp Tyr Val
210 215 220493321DNAHomo sapiens 49atgaagattt tgatacttgg tatttttctg
tttttatgta gtaccccagc ctgggcgaaa 60gaaaagcatt attacattgg aattattgaa
acgacttggg attatgcctc tgaccatggg 120gaaaagaaac ttatttctgt
tgacacggaa cattccaata tctatcttca aaatggccca 180gatagaattg
ggagactata taagaaggcc ctttatcttc agtacacaga tgaaaccttt
240aggacaacta tagaaaaacc ggtctggctt gggtttttag gccctattat
caaagctgaa 300actggagata aagtttatgt acacttaaaa aaccttgcct
ctaggcccta cacctttcat 360tcacatggaa taacttacta taaggaacat
gagggggcca tctaccctga taacaccaca 420gattttcaaa gagcagatga
caaagtatat ccaggagagc agtatacata catgttgctt 480gccactgaag
aacaaagtcc tggggaagga gatggcaatt gtgtgactag gatttaccat
540tcccacattg atgctccaaa agatattgcc tcaggactca tcggaccttt
aataatctgt 600aaaaaagatt ctctagataa agaaaaagaa aaacatattg
accgagaatt tgtggtgatg 660ttttctgtgg tggatgaaaa tttcagctgg
tacctagaag acaacattaa aacctactgc 720tcagaaccag agaaagttga
caaagacaac gaagacttcc aggagagtaa cagaatgtat 780tctgtgaatg
gatacacttt tggaagtctc ccaggactct ccatgtgtgc tgaagacaga
840gtaaaatggt acctttttgg tatgggtaat gaagttgatg tgcacgcagc
tttctttcac 900gggcaagcac tgactaacaa gaactaccgt attgacacaa
tcaacctctt tcctgctacc 960ctgtttgatg cttatatggt ggcccagaac
cctggagaat ggatgctcag ctgtcagaat 1020ctaaaccatc tgaaagccgg
tttgcaagcc tttttccagg tccaggagtg taacaagtct 1080tcatcaaagg
ataatatccg tgggaagcat gttagacact actacattgc cgctgaggaa
1140atcatctgga actatgctcc ctctggtata gacatcttca ctaaagaaaa
cttaacagca 1200cctggaagtg actcagcggt gttttttgaa caaggtacca
caagaattgg aggctcttat 1260aaaaagctgg tttatcgtga gtacacagat
gcctccttca caaatcgaaa ggagagaggc 1320cctgaagaag agcatcttgg
catcctgggt cctgtcattt gggcagaggt gggagacacc 1380atcagagtaa
ccttccataa caaaggagca tatcccctca gtattgagcc gattggggtg
1440agattcaata agaacaacga gggcacatac tattccccaa attacaaccc
ccagagcaga 1500agtgtgcctc cttcagcctc ccatgtggca cccacagaaa
cattcaccta tgaatggact 1560gtccccaaag aagtaggacc cactaatgca
gatcctgtgt gtctagctaa gatgtattat 1620tctgctgtgg atcccactaa
agatatattc actgggctta ttgggccaat gaaaatatgc 1680aagaaaggaa
gtttacatgc aaatgggaga cagaaagatg tagacaagga attctatttg
1740tttcctacag tatttgatga gaatgagagt ttactcctgg aagataatat
tagaatgttt 1800acaactgcac ctgatcaggt ggataaggaa gatgaagact
ttcaggaatc taataaaatg 1860cactccatga atggattcat gtatgggaat
cagccgggtc tcactatgtg caaaggagat 1920tcggtcgtgt ggtacttatt
cagcgccgga aatgaggccg atgtacatgg aatatacttt 1980tcaggaaaca
catatctgtg gagaggagaa cggagagaca cagcaaacct cttccctcaa
2040acaagtctta cgctccacat gtggcctgac acagagggga cttttaatgt
tgaatgcctt 2100acaactgatc attacacagg cggcatgaag caaaaatata
ctgtgaacca atgcaggcgg 2160cagtctgagg attccacctt ctacctggga
gagaggacat actatatcgc agcagtggag 2220gtggaatggg attattcccc
acaaagggag tgggaaaagg agctgcatca tttacaagag 2280cagaatgttt
caaatgcatt tttagataag ggagagtttt acataggctc aaagtacaag
2340aaagttgtgt atcggcagta tactgatagc acattccgtg ttccagtgga
gagaaaagct 2400gaagaagaac atctgggaat tctaggtcca caacttcatg
cagatgttgg agacaaagtc 2460aaaattatct ttaaaaacat ggccacaagg
ccctactcaa tacatgccca tggggtacaa 2520acagagagtt ctacagttac
tccaacatta ccaggtgaaa ctctcactta cgtatggaaa 2580atcccagaaa
gatctggagc tggaacagag gattctgctt gtattccatg ggcttattat
2640tcaactgtgg atcaagttaa ggacctctac agtggattaa ttggccccct
gattgtttgt 2700cgaagacctt acttgaaagt attcaatccc agaaggaagc
tggaatttgc ccttctgttt 2760ctagtttttg atgagaatga atcttggtac
ttagatgaca acatcaaaac atactctgat 2820caccccgaga aagtaaacaa
agatgatgag gaattcatag aaagcaataa aatgcatgct 2880attaatggaa
gaatgtttgg aaacctacaa ggcctcacaa tgcacgtggg agatgaagtc
2940aactggtatc tgatgggaat gggcaatgaa atagacttac acactgtaca
ttttcacggc 3000catagcttcc aatacaagca caggggagtt tatagttctg
atgtctttga cattttccct 3060ggaacatacc aaaccctaga aatgtttcca
agaacacctg gaatttggtt actccactgc 3120catgtgaccg accacattca
tgctggaatg gaaaccactt acaccgttct acaaaatgaa 3180gacaccaaat
ctggctgaat gaaataaatt ggtgataagt ggaaaaaaga gaaaaaccaa
3240tgattcataa caatgtatgt gaaagtgtaa aatagaatgt tactttggaa
tgactataaa 3300cattaaaaga gactggagca t 3321501065PRTHomo sapiens
50Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 1
5 10 15Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr
Thr 20 25 30Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser
Val Asp 35 40 45Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp
Arg Ile Gly 50 55 60Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr
Asp Glu Thr Phe65 70 75 80Arg Thr Thr Ile Glu Lys Pro Val Trp Leu
Gly Phe Leu Gly Pro Ile 85 90 95Ile Lys Ala Glu Thr Gly Asp Lys Val
Tyr Val His Leu Lys Asn Leu 100 105 110Ala Ser Arg Pro Tyr Thr Phe
His Ser His Gly Ile Thr Tyr Tyr Lys 115 120 125Glu His Glu Gly Ala
Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg 130 135 140Ala Asp Asp
Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu145 150 155
160Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr
165 170 175Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala
Ser Gly 180 185 190Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser
Leu Asp Lys Glu 195 200 205Lys Glu Lys His Ile Asp Arg Glu Phe Val
Val Met Phe Ser Val Val 210 215 220Asp Glu Asn Phe Ser Trp Tyr Leu
Glu Asp Asn Ile Lys Thr Tyr Cys225 230 235 240Ser Glu Pro Glu Lys
Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser 245 250 255Asn Arg Met
Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly 260 265 270Leu
Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met 275 280
285Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu
290 295 300Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro
Ala Thr305 310 315 320Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro
Gly Glu Trp Met Leu 325 330 335Ser Cys Gln Asn Leu Asn His Leu Lys
Ala Gly Leu Gln Ala Phe Phe 340 345 350Gln Val Gln Glu Cys Asn Lys
Ser Ser Ser Lys Asp Asn Ile Arg Gly 355 360 365Lys His Val Arg His
Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn 370 375 380Tyr Ala Pro
Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala385 390 395
400Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile
405 410 415Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp
Ala Ser 420 425 430Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu
His Leu Gly Ile 435 440 445Leu Gly Pro Val Ile Trp Ala Glu Val Gly
Asp Thr Ile Arg Val Thr 450 455 460Phe His Asn Lys Gly Ala Tyr Pro
Leu Ser Ile Glu Pro Ile Gly Val465 470 475 480Arg Phe Asn Lys Asn
Asn Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn 485 490 495Pro Gln Ser
Arg Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr 500 505 510Glu
Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr 515 520
525Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Asp
530 535 540Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys
Ile Cys545 550 555 560Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln
Lys Asp Val Asp Lys 565 570 575Glu Phe Tyr Leu Phe Pro Thr Val Phe
Asp Glu Asn Glu Ser Leu Leu 580 585 590Leu Glu Asp Asn Ile Arg Met
Phe Thr Thr Ala Pro Asp Gln Val Asp 595 600 605Lys Glu Asp Glu Asp
Phe Gln Glu Ser Asn Lys Met His Ser Met Asn 610 615 620Gly Phe Met
Tyr Gly Asn Gln Pro Gly Leu Thr Met Cys Lys Gly Asp625 630 635
640Ser Val Val Trp Tyr Leu Phe Ser Ala Gly Asn Glu Ala Asp Val His
645 650 655Gly Ile Tyr Phe Ser Gly Asn Thr Tyr Leu Trp Arg Gly Glu
Arg Arg 660 665 670Asp Thr Ala Asn Leu Phe Pro Gln Thr Ser Leu Thr
Leu His Met Trp 675 680 685Pro Asp Thr Glu Gly Thr Phe Asn Val Glu
Cys Leu Thr Thr Asp His 690 695 700Tyr Thr Gly Gly Met Lys Gln Lys
Tyr Thr Val Asn Gln Cys Arg Arg705 710 715 720Gln Ser Glu Asp Ser
Thr Phe Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile 725 730 735Ala Ala Val
Glu Val Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu 740 745 750Lys
Glu Leu His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu 755 760
765Asp Lys Gly Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr
770 775 780Arg Gln Tyr Thr Asp Ser Thr Phe Arg Val Pro Val Glu Arg
Lys Ala785 790 795 800Glu Glu Glu His Leu Gly Ile Leu Gly Pro Gln
Leu His Ala Asp Val 805 810 815Gly Asp Lys Val Lys Ile Ile Phe Lys
Asn Met Ala Thr Arg Pro Tyr 820 825 830Ser Ile His Ala His Gly Val
Gln Thr Glu Ser Ser Thr Val Thr Pro 835 840 845Thr Leu Pro Gly Glu
Thr Leu Thr Tyr Val Trp Lys Ile Pro Glu Arg 850 855 860Ser Gly Ala
Gly Thr Glu Asp Ser Ala Cys Ile Pro
Trp Ala Tyr Tyr865 870 875 880Ser Thr Val Asp Gln Val Lys Asp Leu
Tyr Ser Gly Leu Ile Gly Pro 885 890 895Leu Ile Val Cys Arg Arg Pro
Tyr Leu Lys Val Phe Asn Pro Arg Arg 900 905 910Lys Leu Glu Phe Ala
Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser 915 920 925Trp Tyr Leu
Asp Asp Asn Ile Lys Thr Tyr Ser Asp His Pro Glu Lys 930 935 940Val
Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser Asn Lys Met His Ala945 950
955 960Ile Asn Gly Arg Met Phe Gly Asn Leu Gln Gly Leu Thr Met His
Val 965 970 975Gly Asp Glu Val Asn Trp Tyr Leu Met Gly Met Gly Asn
Glu Ile Asp 980 985 990Leu His Thr Val His Phe His Gly His Ser Phe
Gln Tyr Lys His Arg 995 1000 1005Gly Val Tyr Ser Ser Asp Val Phe
Asp Ile Phe Pro Gly Thr Tyr Gln 1010 1015 1020Thr Leu Glu Met Phe
Pro Arg Thr Pro Gly Ile Trp Leu Leu His Cys1025 1030 1035 1040His
Val Thr Asp His Ile His Ala Gly Met Glu Thr Thr Tyr Thr Val 1045
1050 1055Leu Gln Asn Glu Asp Thr Lys Ser Gly 1060 1065511603DNAHomo
sapiens 51ggccagggat caggcagcgg ctcaggcgac cctgagtgtg cccccacccc
gccatggccc 60ggctgctgca ggcgtcctgc ctgctttccc tgctcctggc cggcttcgtc
tcgcagagcc 120ggggacaaga gaagtcgaag atggactgcc atggtggcat
aagtggcacc atttacgagt 180acggagccct caccattgat ggggaggagt
acatcccctt caagcagtat gctggcaaat 240acgtcctctt tgtcaacgtg
gccagctact gaggcctgac gggccagtac attgaactga 300atgcactaca
ggaagagctt gcaccattcg gtctggtcat tctgggcttt ccctgcaacc
360aatttggaaa acaggaacca ggagagaact cagagatcct tcctaccctc
aagtatgtcc 420gaccaggtgg aggctttgtc cctaatttcc agctctttga
gaaaggggat gtcaatggag 480agaaagagca gaaattctac actttcctaa
agaactcctg tcctcccacc tcggagctcc 540tgggtacatc tgaccgcctc
ttctgggaac ccatgaaggt tcacgacatc cgctggaact 600ttgagaagtt
cctggtgggg ccagatggta tacccatcat gcgctggcac caccggacca
660cggtcagcaa cgtcaagatg gacatcctgt cctacatgag gcggcaggca
gccctggggg 720tcaagaggaa gtaactgaag gccgtctcat cccatgtcca
ccatgtaggg gagggacttt 780gttcaggaag aaatccgtgt ctccaaccac
actatctacc catcacagac ccctttccta 840tcactcaagg ccccagcctg
gcacaaatgg atgcatacag ttctgtgtac tgccaggcat 900gtgggtgtgg
gtgcatgtgg gtgtttacac acatgcctac aggtatgcgt gattgtgtgt
960gtgtgcatgg gtgtacagcc acgtgtccta cctatgtgtc tttctgggaa
tgtgtaccat 1020ctgtgtgcct gcagctgtgt agtgctggac agtgacaacc
ctttctctcc agttctccac 1080tccaatgata atagttcact tacacctaaa
cccaaaggaa aaaccagctc taggtccaat 1140tgttctgctc taactgatac
ctcaaccttg gggccagcat ctcccactgc ctccaaatat 1200tagtaactat
gactgacgtc cccagaagtt tctgggtcta ccacactccc caacccccca
1260ctcctacttc ctgaagggcc ctcccaaggc tacatcccca ccccacagtt
ctccctgaga 1320gagatcaacc tccctagatc aaccaaggca gatgtgacaa
gcaagggcca cggaccccat 1380aggcaggggt ggcgtcttca tgagggaggg
gcccaaagcc cttgtgggcg gacctcccct 1440gagcctgtct gaggggccag
cccttagtgc attcaggcta aggcccctgg gcagggatgc 1500caccctgctc
cttcggagga cgtgccctca cccctcactg gtccactggc ttgagactca
1560ccccgtctgc ccagtaaaag cctttctgca gcaaaaaacc ccc
160352226PRTHomo sapiensVARIANT0-00Xaa = any amino acid 52Met Ala
Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 1 5 10
15Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Met Asp Cys
20 25 30His Gly Gly Ile Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr
Ile 35 40 45Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys
Tyr Val 50 55 60Leu Phe Val Asn Val Ala Ser Tyr Xaa Gly Leu Thr Gly
Gln Tyr Ile65 70 75 80Glu Leu Asn Ala Leu Gln Glu Glu Leu Ala Pro
Phe Gly Leu Val Ile 85 90 95Leu Gly Phe Pro Cys Asn Gln Phe Gly Lys
Gln Glu Pro Gly Glu Asn 100 105 110Ser Glu Ile Leu Pro Thr Leu Lys
Tyr Val Arg Pro Gly Gly Gly Phe 115 120 125Val Pro Asn Phe Gln Leu
Phe Glu Lys Gly Asp Val Asn Gly Glu Lys 130 135 140Glu Gln Lys Phe
Tyr Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser145 150 155 160Glu
Leu Leu Gly Thr Ser Asp Arg Leu Phe Trp Glu Pro Met Lys Val 165 170
175His Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly
180 185 190Ile Pro Ile Met Arg Trp His His Arg Thr Thr Val Ser Asn
Val Lys 195 200 205Met Asp Ile Leu Ser Tyr Met Arg Arg Gln Ala Ala
Leu Gly Val Lys 210 215 220Arg Lys22553399DNAHomo sapiens
53atgaagtcca gcggcctctt ccccttcctg gtgctgcttg ccctgggaac tctggcacct
60tgggctgtgg aaggctctgg aaagtccttc aaagctggag tctgtcctcc taagaaatct
120gcccagtgcc ttagatacaa gaaacctgag tgccagagtg actggcagtg
tccagggaag 180aagagatgtt gtcctgacac ttgtggcatc aaatgcctgg
atcctgttga caccccaaac 240ccaacaagga ggaagcctgg gaagtgccca
gtgacttatg gccaatgttt gatgcttaac 300ccccccaatt tctgtgagat
ggatggccag tgcaagcgtg acttgaagtg ttgcatgggc 360atgtgtggga
aatcctgcgt ttcccctgtg aaagcttga 39954132PRTHomo sapiens 54Met Lys
Ser Ser Gly Leu Phe Pro Phe Leu Val Leu Leu Ala Leu Gly 1 5 10
15Thr Leu Ala Pro Trp Ala Val Glu Gly Ser Gly Lys Ser Phe Lys Ala
20 25 30Gly Val Cys Pro Pro Lys Lys Ser Ala Gln Cys Leu Arg Tyr Lys
Lys 35 40 45Pro Glu Cys Gln Ser Asp Trp Gln Cys Pro Gly Lys Lys Arg
Cys Cys 50 55 60Pro Asp Thr Cys Gly Ile Lys Cys Leu Asp Pro Val Asp
Thr Pro Asn65 70 75 80Pro Thr Arg Arg Lys Pro Gly Lys Cys Pro Val
Thr Tyr Gly Gln Cys 85 90 95Leu Met Leu Asn Pro Pro Asn Phe Cys Glu
Met Asp Gly Gln Cys Lys 100 105 110Arg Asp Leu Lys Cys Cys Met Gly
Met Cys Gly Lys Ser Cys Val Ser 115 120 125Pro Val Lys Ala
130553557DNAHomo sapiens 55gagagggtcc ttcagggtct gcttatgccc
ttgttcaaga acaccagtgt cagctctctg 60tactctggtt gcagactgac cttgctcagg
cctgagaagg atggggcagc caccagagtg 120gatgctgtct gcacccatcg
tcctgacccc aaaagccctg gactggacag agagcggctg 180tactggaagc
tgagccagct gacccacggc atcactgagc tgggccccta caccctggac
240aggcacagtc tctatgtcaa tggtttcacc catcagagct ctatgacgac
caccagaact 300cctgatacct ccacaatgca cctggcaacc tcgagaactc
cagcctccct gtctggacct 360acgaccgcca gccctctcct ggtgctattc
acaattaact tcaccatcac taacctgcgg 420tatgaggaga acatgcatca
ccctggctct agaaagttta acaccacgga gagagtcctt 480cagggtctgc
tcaggcctgt gttcaagaac accagtgttg gccctctgta ctctggctgc
540agactgacct tgctcaggcc caagaaggat ggggcagcca ccaaagtgga
tgccatctgc 600acctaccgcc ctgatcccaa aagccctgga ctggacagag
agcagctata ctgggagctg 660agccagctaa cccacagcat cactgagctg
ggcccctaca ccctggacag ggacagtctc 720tatgtcaatg gtttcacaca
gcggagctct gtgcccacca ctagcattcc tgggaccccc 780acagtggacc
tgggaacatc tgggactcca gtttctaaac ctggtccctc ggctgccagc
840cctctcctgg tgctattcac tctcaacttc accatcacca acctgcggta
tgaggagaac 900atgcagcacc ctggctccag gaagttcaac accacggaga
gggtccttca gggcctgctc 960aggtccctgt tcaagagcac cagtgttggc
cctctgtact ctggctgcag actgactttg 1020ctcaggcctg aaaaggatgg
gacagccact ggagtggatg ccatctgcac ccaccaccct 1080gaccccaaaa
gccctaggct ggacagagag cagctgtatt gggagctgag ccagctgacc
1140cacaatatca ctgagctggg ccactatgcc ctggacaacg acagcctctt
tgtcaatggt 1200ttcactcatc ggagctctgt gtccaccacc agcactcctg
ggacccccac agtgtatctg 1260ggagcatcta agactccagc ctcgatattt
ggcccttcag ctgccagcca tctcctgata 1320ctattcaccc tcaacttcac
catcactaac ctgcggtatg aggagaacat gtggcctggc 1380tccaggaagt
tcaacactac agagagggtc cttcagggcc tgctaaggcc cttgttcaag
1440aacaccagtg ttggccctct gtactctggc tccaggctga ccttgctcag
gccagagaaa 1500gatggggaag ccaccggagt ggatgccatc tgcacccacc
gccctgaccc cacaggccct 1560gggctggaca gagagcagct gtatttggag
ctgagccagc tgacccacag catcactgag 1620ctgggcccct acacactgga
cagggacagt ctctatgtca atggtttcac ccatcggagc 1680tctgtaccca
ccaccagcac cggggtggtc agcgaggagc cattcacact gaacttcacc
1740atcaacaacc tgcgctacat ggcggacatg ggccaacccg gctccctcaa
gttcaacatc 1800acagacaacg tcatgaagca cctgctcagt cctttgttcc
agaggagcag cctgggtgca 1860cggtacacag gctgcagggt catcgcacta
aggtctgtga agaacggtgc tgagacacgg 1920gtggacctcc tctgcaccta
cctgcagccc ctcagcggcc caggtctgcc tatcaagcag 1980gtgttccatg
agctgagcca gcagacccat ggcatcaccc ggctgggccc ctactctctg
2040gacaaagaca gcctctacct taacggttac aatgaacctg gtctagatga
gcctcctaca 2100actcccaagc cagccaccac attcctgcct cctctgtcag
aagccacaac agccatgggg 2160taccacctga agaccctcac actcaacttc
accatctcca atctccagta ttcaccagat 2220atgggcaagg gctcagctac
attcaactcc accgaggggg tccttcagca cctgctcaga 2280cccttgttcc
agaagagcag catgggcccc ttctacttgg gttgccaact gatctccctc
2340aggcctgaga aggatggggc agccactggt gtggacacca cctgcaccta
ccaccctgac 2400cctgtgggcc ccgggctgga catacagcag ctttactggg
agctgagtca gctgacccat 2460ggtgtcaccc aactgggctt ctatgtcctg
gacagggata gcctcttcat caatggctat 2520gcaccccaga atttatcaat
ccggggcgag taccagataa atttccacat tgtcaactgg 2580aacctcagta
atccagaccc cacatcctca gagtacatca ccctgctgag ggacatccag
2640gacaaggtca ccacactcta caaaggcagt caactacatg acacattccg
cttctgcctg 2700gtcaccaact tgacgatgga ctccgtgttg gtcactgtca
aggcattgtt ctcctccaat 2760ttggacccca gcctggtgga gcaagtcttt
ctagataaga ccctgaatgc ctcattccat 2820tggctgggct ccacctacca
gttggtggac atccatgtga cagaaatgga gtcatcagtt 2880tatcaaccaa
caagcagctc cagcacccag cacttctacc cgaatttcac catcaccaac
2940ctaccatatt cccaggacaa agcccagcca ggcaccacca attaccagag
gaacaaaagg 3000aatattgagg atgcgctcaa ccaactcttc cgaaacagca
gcatcaagag ttatttttct 3060gactgtcaag tttcaacatt caggtctgtc
cccaacaggc accacaccgg ggtggactcc 3120ctgtgtaact tctcgccact
ggctcggaga gtagacagag ttgccatcta tgaggaattt 3180ctgcggatga
cccggaatgg tacccagctg cagaacttca ccctggacag gagcagtgtc
3240cttgtggatg ggtattctcc caacagaaat gagcccttaa ctgggaattc
tgaccttccc 3300ttctgggctg tcatcttcat cggcttggca ggactcctgg
gactcatcac atgcctgatc 3360tgcggtgtcc tggtgaccac ccgccggcgg
aagaaggaag gagaatacaa cgtccagcaa 3420cagtgcccag gctactacca
gtcacaccta gacctggagg atctgcaatg actggaactt 3480gccggtgcct
ggggtgcctt tcccccagcc agggtccaaa gaagcttggc tggggcagaa
3540ataaaccata ttggtcg 3557561148PRTHomo sapiens 56Met Pro Leu Phe
Lys Asn Thr Ser Val Ser Ser Leu Tyr Ser Gly Cys 1 5 10 15Arg Leu
Thr Leu Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Arg Val 20 25 30Asp
Ala Val Cys Thr His Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp 35 40
45Arg Glu Arg Leu Tyr Trp Lys Leu Ser Gln Leu Thr His Gly Ile Thr
50 55 60Glu Leu Gly Pro Tyr Thr Leu Asp Arg His Ser Leu Tyr Val Asn
Gly65 70 75 80Phe Thr His Gln Ser Ser Met Thr Thr Thr Arg Thr Pro
Asp Thr Ser 85 90 95Thr Met His Leu Ala Thr Ser Arg Thr Pro Ala Ser
Leu Ser Gly Pro 100 105 110Thr Thr Ala Ser Pro Leu Leu Val Leu Phe
Thr Ile Asn Phe Thr Ile 115 120 125Thr Asn Leu Arg Tyr Glu Glu Asn
Met His His Pro Gly Ser Arg Lys 130 135 140Phe Asn Thr Thr Glu Arg
Val Leu Gln Gly Leu Leu Arg Pro Val Phe145 150 155 160Lys Asn Thr
Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu 165 170 175Leu
Arg Pro Lys Lys Asp Gly Ala Ala Thr Lys Val Asp Ala Ile Cys 180 185
190Thr Tyr Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp Arg Glu Gln Leu
195 200 205Tyr Trp Glu Leu Ser Gln Leu Thr His Ser Ile Thr Glu Leu
Gly Pro 210 215 220Tyr Thr Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly
Phe Thr Gln Arg225 230 235 240Ser Ser Val Pro Thr Thr Ser Ile Pro
Gly Thr Pro Thr Val Asp Leu 245 250 255Gly Thr Ser Gly Thr Pro Val
Ser Lys Pro Gly Pro Ser Ala Ala Ser 260 265 270Pro Leu Leu Val Leu
Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Arg 275 280 285Tyr Glu Glu
Asn Met Gln His Pro Gly Ser Arg Lys Phe Asn Thr Thr 290 295 300Glu
Arg Val Leu Gln Gly Leu Leu Arg Ser Leu Phe Lys Ser Thr Ser305 310
315 320Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro
Glu 325 330 335Lys Asp Gly Thr Ala Thr Gly Val Asp Ala Ile Cys Thr
His His Pro 340 345 350Asp Pro Lys Ser Pro Arg Leu Asp Arg Glu Gln
Leu Tyr Trp Glu Leu 355 360 365Ser Gln Leu Thr His Asn Ile Thr Glu
Leu Gly His Tyr Ala Leu Asp 370 375 380Asn Asp Ser Leu Phe Val Asn
Gly Phe Thr His Arg Ser Ser Val Ser385 390 395 400Thr Thr Ser Thr
Pro Gly Thr Pro Thr Val Tyr Leu Gly Ala Ser Lys 405 410 415Thr Pro
Ala Ser Ile Phe Gly Pro Ser Ala Ala Ser His Leu Leu Ile 420 425
430Leu Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Arg Tyr Glu Glu Asn
435 440 445Met Trp Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val
Leu Gln 450 455 460Gly Leu Leu Arg Pro Leu Phe Lys Asn Thr Ser Val
Gly Pro Leu Tyr465 470 475 480Ser Gly Ser Arg Leu Thr Leu Leu Arg
Pro Glu Lys Asp Gly Glu Ala 485 490 495Thr Gly Val Asp Ala Ile Cys
Thr His Arg Pro Asp Pro Thr Gly Pro 500 505 510Gly Leu Asp Arg Glu
Gln Leu Tyr Leu Glu Leu Ser Gln Leu Thr His 515 520 525Ser Ile Thr
Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asp Ser Leu Tyr 530 535 540Val
Asn Gly Phe Thr His Arg Ser Ser Val Pro Thr Thr Ser Thr Gly545 550
555 560Val Val Ser Glu Glu Pro Phe Thr Leu Asn Phe Thr Ile Asn Asn
Leu 565 570 575Arg Tyr Met Ala Asp Met Gly Gln Pro Gly Ser Leu Lys
Phe Asn Ile 580 585 590Thr Asp Asn Val Met Lys His Leu Leu Ser Pro
Leu Phe Gln Arg Ser 595 600 605Ser Leu Gly Ala Arg Tyr Thr Gly Cys
Arg Val Ile Ala Leu Arg Ser 610 615 620Val Lys Asn Gly Ala Glu Thr
Arg Val Asp Leu Leu Cys Thr Tyr Leu625 630 635 640Gln Pro Leu Ser
Gly Pro Gly Leu Pro Ile Lys Gln Val Phe His Glu 645 650 655Leu Ser
Gln Gln Thr His Gly Ile Thr Arg Leu Gly Pro Tyr Ser Leu 660 665
670Asp Lys Asp Ser Leu Tyr Leu Asn Gly Tyr Asn Glu Pro Gly Leu Asp
675 680 685Glu Pro Pro Thr Thr Pro Lys Pro Ala Thr Thr Phe Leu Pro
Pro Leu 690 695 700Ser Glu Ala Thr Thr Ala Met Gly Tyr His Leu Lys
Thr Leu Thr Leu705 710 715 720Asn Phe Thr Ile Ser Asn Leu Gln Tyr
Ser Pro Asp Met Gly Lys Gly 725 730 735Ser Ala Thr Phe Asn Ser Thr
Glu Gly Val Leu Gln His Leu Leu Arg 740 745 750Pro Leu Phe Gln Lys
Ser Ser Met Gly Pro Phe Tyr Leu Gly Cys Gln 755 760 765Leu Ile Ser
Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Gly Val Asp 770 775 780Thr
Thr Cys Thr Tyr His Pro Asp Pro Val Gly Pro Gly Leu Asp Ile785 790
795 800Gln Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Gly Val Thr
Gln 805 810 815Leu Gly Phe Tyr Val Leu Asp Arg Asp Ser Leu Phe Ile
Asn Gly Tyr 820 825 830Ala Pro Gln Asn Leu Ser Ile Arg Gly Glu Tyr
Gln Ile Asn Phe His 835 840 845Ile Val Asn Trp Asn Leu Ser Asn Pro
Asp Pro Thr Ser Ser Glu Tyr 850 855 860Ile Thr Leu Leu Arg Asp Ile
Gln Asp Lys Val Thr Thr Leu Tyr Lys865 870 875 880Gly Ser Gln Leu
His Asp Thr Phe Arg Phe Cys Leu Val Thr Asn Leu 885 890 895Thr Met
Asp Ser Val Leu Val Thr Val Lys Ala Leu Phe Ser Ser Asn 900 905
910Leu Asp Pro Ser Leu Val Glu Gln Val Phe Leu Asp Lys Thr Leu Asn
915 920 925Ala Ser Phe His Trp Leu Gly Ser Thr Tyr Gln Leu Val Asp
Ile His 930 935 940Val Thr Glu Met Glu Ser Ser Val Tyr Gln Pro Thr
Ser Ser Ser Ser945 950 955 960Thr Gln His Phe Tyr Pro Asn Phe Thr
Ile Thr Asn Leu Pro Tyr Ser
965 970 975Gln Asp Lys Ala Gln Pro Gly Thr Thr Asn Tyr Gln Arg Asn
Lys Arg 980 985 990Asn Ile Glu Asp Ala Leu Asn Gln Leu Phe Arg Asn
Ser Ser Ile Lys 995 1000 1005Ser Tyr Phe Ser Asp Cys Gln Val Ser
Thr Phe Arg Ser Val Pro Asn 1010 1015 1020Arg His His Thr Gly Val
Asp Ser Leu Cys Asn Phe Ser Pro Leu Ala1025 1030 1035 1040Arg Arg
Val Asp Arg Val Ala Ile Tyr Glu Glu Phe Leu Arg Met Thr 1045 1050
1055Arg Asn Gly Thr Gln Leu Gln Asn Phe Thr Leu Asp Arg Ser Ser Val
1060 1065 1070Leu Val Asp Gly Tyr Ser Pro Asn Arg Asn Glu Pro Leu
Thr Gly Asn 1075 1080 1085Ser Asp Leu Pro Phe Trp Ala Val Ile Phe
Ile Gly Leu Ala Gly Leu 1090 1095 1100Leu Gly Leu Ile Thr Cys Leu
Ile Cys Gly Val Leu Val Thr Thr Arg1105 1110 1115 1120Arg Arg Lys
Lys Glu Gly Glu Tyr Asn Val Gln Gln Gln Cys Pro Gly 1125 1130
1135Tyr Tyr Gln Ser His Leu Asp Leu Glu Asp Leu Gln 1140
114557853DNAHomo sapiens 57ctagtcctga cttcacttct gatgaggaag
cctctctcct tagccttcag cctttcctcc 60caccctgcca taagtaattt gatcctcaag
aagttaaacc acacctcatt ggtccctggc 120taattcacca atttacaaac
agcaggaaat agaaacttaa gagaaataca cacttctgag 180aaactgaaac
gacaggggaa aggaggtctc actgagcacc gtcccagcat ccggacacca
240cagcggccct tcgctccacg cagaaaacca cacttctcaa accttcactc
aacacttcct 300tccccaaagc cagaagatgc acaaggagga acatgaggtg
gctgtgctgg gggcaccccc 360cagcaccatc cttccaaggt ccaccgtgat
caacatccac agcgagacct ccgtgcccga 420ccatgtcgtc tggtccctgt
tcaacaccct cttcttgaac tggtgctgtc tgggcttcat 480agcattcgcc
tactccgtga agtctaggga caggaagatg gttggcgacg tgaccggggc
540ccaggcctat gcctccaccg ccaagtgcct gaacatctgg gccctgattc
tgggcatcct 600catgaccatt ggattcatcc tgtcactggt attcggctct
gtgacagtct accatattat 660gttacagata atacaggaaa aacggggtta
ctagtagccg cccatagcct gcaacctttg 720cactccactg tgcaatgctg
gccctgcacg ctggggctgt tgcccctgcc cccttggtcc 780tgcccctaga
tacagcagtt tatacccaca cacctgtcta cagtgtcatt caataaagtg
840cacgtgcttg tga 85358125PRTHomo sapiens 58Met His Lys Glu Glu His
Glu Val Ala Val Leu Gly Ala Pro Pro Ser 1 5 10 15Thr Ile Leu Pro
Arg Ser Thr Val Ile Asn Ile His Ser Glu Thr Ser 20 25 30Val Pro Asp
His Val Val Trp Ser Leu Phe Asn Thr Leu Phe Leu Asn 35 40 45Trp Cys
Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser Arg 50 55 60Asp
Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln Ala Tyr Ala Ser65 70 75
80Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu Gly Ile Leu Met
85 90 95Thr Ile Gly Phe Ile Leu Ser Leu Val Phe Gly Ser Val Thr Val
Tyr 100 105 110His Ile Met Leu Gln Ile Ile Gln Glu Lys Arg Gly Tyr
115 120 125591512DNAHomo sapiens 59ttccggtccc ccaggacatg tccaatcagg
gaagtaagta cgtcaataag gaaattcaaa 60atgctgtcaa cggggtgaaa cagataaaga
ctctcataga aaaaacaaac gaagagcgca 120agacactgct cagcaaccta
gaagaagcca agaagaagaa agaggatgcc ctaaatgaga 180ccagggaatc
agagacaaag ctgaaggagc tcccaggagt gtgcaatgag accatgatgg
240ccctctggga agagtgtaag ccctgcctga aacagacctg catgaagttc
tacgcacgcg 300tctgcagaag tggctcaggc ctggttggcc gccagcttga
ggagttcctg aaccagagct 360cgcccttcta cttctggatg aatggtgacc
gcatcgactc cctgctggag aacgaccggc 420agcagacgca catgctggat
gtcatgcagg accacttcag ccgcgcgtcc agcatcatag 480acgagctctt
ccaggacagg ttcttcaccc gggagcccca ggatacctac cactacctgc
540ccttcagcct gccccaccgg aggcctcact tcttctttcc caagtcccgc
atcgtccgca 600gcttgatgcc cttctctccg tacgagcccc tgaacttcca
cgccatgttc cagcccttcc 660ttgagatgat acacgaggct cagcaggcca
tggacatcca cttccacagc ccggccttcc 720agcacccgcc aacagaattc
atacgagaag gcgacgatga ccggactgtg tgccgggaga 780tccgccacaa
ctccacgggc tgcctgcgga tgaaggacca gtgtgacaag tgccgggaga
840tcttgtctgt ggactgttcc accaacaacc cctcccaggc taagctgcgg
cgggagctcg 900acgaatccct ccaggtcgct gagaggttga ccaggaaata
caacgagctg ctaaagtcct 960accagtggaa gatgctcaac acctcctcct
tgctggagca gctgaacgag cagtttaact 1020gggtgtcccg gctggcaaac
ctcacgcaag gcgaagacca gtactatctg cgggtcacca 1080cggtggcttc
ccacacttct gactcggacg ttccttccgg tgtcactgag gtggtcgtga
1140agctctttga ctctgatccc atcactgtga cggtccctgt agaagtctcc
aggaagaacc 1200ctaaatttat ggagaccgtg gcggagaaag cgctgcagga
ataccgcaaa aagcaccggg 1260aggagtgaga tgtggatgtt gcttttgcac
ctacgggggc atctgagtcc agctcccccc 1320aagatgagct gcagcccccc
agagagagct ctgcacgtca ccaagtaacc aggccccagc 1380ctccaggccc
ccaactccgc ccagcctctc cccgctctgg atcctgcact ctaacactcg
1440actctgctgc tcatgggaag aacagaattg ctcctgcatg caactaattc
aataaaactg 1500tcttgtgagc tg 151260416PRTHomo sapiens 60Met Ser Asn
Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala 1 5 10 15Val
Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu 20 25
30Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys
35 40 45Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys
Glu 50 55 60Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu
Glu Cys65 70 75 80Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr
Ala Arg Val Cys 85 90 95Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu
Glu Glu Phe Leu Asn 100 105 110Gln Ser Ser Pro Phe Tyr Phe Trp Met
Asn Gly Asp Arg Ile Asp Ser 115 120 125Leu Leu Glu Asn Asp Arg Gln
Gln Thr His Met Leu Asp Val Met Gln 130 135 140Asp His Phe Ser Arg
Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp145 150 155 160Arg Phe
Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe 165 170
175Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile
180 185 190Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn
Phe His 195 200 205Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu
Ala Gln Gln Ala 210 215 220Met Asp Ile His Phe His Ser Pro Ala Phe
Gln His Pro Pro Thr Glu225 230 235 240Phe Ile Arg Glu Gly Asp Asp
Asp Arg Thr Val Cys Arg Glu Ile Arg 245 250 255His Asn Ser Thr Gly
Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys 260 265 270Arg Glu Ile
Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala 275 280 285Lys
Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu 290 295
300Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met
Leu305 310 315 320Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln
Phe Asn Trp Val 325 330 335Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu
Asp Gln Tyr Tyr Leu Arg 340 345 350Val Thr Thr Val Ala Ser His Thr
Ser Asp Ser Asp Val Pro Ser Gly 355 360 365Val Thr Glu Val Val Val
Lys Leu Phe Asp Ser Asp Pro Ile Thr Val 370 375 380Thr Val Pro Val
Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr385 390 395 400Val
Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 405 410
415611564DNAHomo sapiens 61cggacgcgtg ggcggacgcg tgggcgaggg
cgcgagtgag gagcagaccc aggcatcgcg 60cgccgagaag gccggagcgt cggcacctga
acgcgaggcg ctccattgcg cgtgcgcgtt 120gaggggcttc ccgcacctga
tcgcgagacc ccaacggctg gtggcgtcgc ctgcgcgggc 180gtccccacac
tgccggtccg gaaaggcgac ttccgggggc tttggcacct ggcggacgct
240cccggagcgt cggcacctga acgcgaggcg ctccattgcg cgtgcgcgtt
gaggggcttc 300ccgcacctga tcgcgagacc ccaacggctg gtggcgtcgc
ctgcgcgtct cggctgagct 360ggccatggcg cacctgtgcg ggctgaggcg
gagccgggcg tttctcgccc tgctgggatc 420gctgctcctc tctggggtcc
tggcggccga ccgagaacgc agcatccacg acttctgcct 480ggtgtcgaag
gtggtgggca gatgccgggc ctccatgcct aagtggtggt acaatgtcac
540tgacggatcc tgccagctgt ttgtgtatgg gggctgtgac ggaaacagca
ataattacct 600gaccaaggag gagtgcctca agaaatgtgc cactgtcaca
gagaatgcca cgggtgacct 660ggccaccagc aggaatgcag cggattcctc
tgtcccaagt gctcccagaa ggcaggattc 720tgaagaccac tccagcgata
tgttcaacta tgaagaatac tgcaccgcca acgcagtcac 780tgggccttgc
cgtgcatcct tcccacgctg gtactttgac gtggagagga actcctgcaa
840taacttcatc tatggaggct gccggggcaa taagaacagc taccgctctg
aggaggcctg 900catgctccgc tgcttccgcc agcaggagaa tcctcccctg
ccccttggct caaaggtggt 960ggttctggcg gggctgttcg tgatggtgtt
gatcctcttc ctgggagcct ccatggtcta 1020cctgatccgg gtggcacgga
ggaaccagga gcgtgccctg cgcaccgtct ggagctccgg 1080acatgacaag
gagcagctgg tgaagaacac atatgtcctg tgaccgccct gtcgccaaga
1140ggactgggga agggagggga gactatgtgt gagctttttt taaatagcgg
gattgactcg 1200gatttgagtg atcattaggg ctgaggtgtg tttctctggg
aggtaggacg gctgcttcct 1260ggtctggcag ggatgggttt gctttggaaa
tcctctagga ggctcctcct cgcatggcct 1320gcagtctggc agcagccccg
agttgtttcc tcgctgatcg atttctttcc tccaggtaga 1380gttttctttg
cttatgttga attccattgc ctcttttctc atcacagaag tgatgttgga
1440atcgtttctt ttgtttgtct gatttatggt ttttttaagt ataaacaaaa
gttttttatt 1500aacatctgaa agaaggaaag taaaatgtac aagtttaata
aaaaggggcc ttccccttta 1560gaat 156462252PRTHomo sapiens 62Met Ala
His Leu Cys Gly Leu Arg Arg Ser Arg Ala Phe Leu Ala Leu 1 5 10
15Leu Gly Ser Leu Leu Leu Ser Gly Val Leu Ala Ala Asp Arg Glu Arg
20 25 30Ser Ile His Asp Phe Cys Leu Val Ser Lys Val Val Gly Arg Cys
Arg 35 40 45Ala Ser Met Pro Lys Trp Trp Tyr Asn Val Thr Asp Gly Ser
Cys Gln 50 55 60Leu Phe Val Tyr Gly Gly Cys Asp Gly Asn Ser Asn Asn
Tyr Leu Thr65 70 75 80Lys Glu Glu Cys Leu Lys Lys Cys Ala Thr Val
Thr Glu Asn Ala Thr 85 90 95Gly Asp Leu Ala Thr Ser Arg Asn Ala Ala
Asp Ser Ser Val Pro Ser 100 105 110Ala Pro Arg Arg Gln Asp Ser Glu
Asp His Ser Ser Asp Met Phe Asn 115 120 125Tyr Glu Glu Tyr Cys Thr
Ala Asn Ala Val Thr Gly Pro Cys Arg Ala 130 135 140Ser Phe Pro Arg
Trp Tyr Phe Asp Val Glu Arg Asn Ser Cys Asn Asn145 150 155 160Phe
Ile Tyr Gly Gly Cys Arg Gly Asn Lys Asn Ser Tyr Arg Ser Glu 165 170
175Glu Ala Cys Met Leu Arg Cys Phe Arg Gln Gln Glu Asn Pro Pro Leu
180 185 190Pro Leu Gly Ser Lys Val Val Val Leu Ala Gly Leu Phe Val
Met Val 195 200 205Leu Ile Leu Phe Leu Gly Ala Ser Met Val Tyr Leu
Ile Arg Val Ala 210 215 220Arg Arg Asn Gln Glu Arg Ala Leu Arg Thr
Val Trp Ser Ser Gly His225 230 235 240Asp Lys Glu Gln Leu Val Lys
Asn Thr Tyr Val Leu 245 250631147DNAHomo sapiens 63ggacgtcctt
ccccaggagc cgactggcca atcacaggca ggaagatgaa ggttctgtgg 60gctgcgttgc
tggtcacatt cctggcagga tgccaggcca aggtggagca agcggtggag
120acagagccgg agcccgagct gcgccagcag accgagtggc agagcggcca
gcgctgggaa 180ctggcactgg gtcgcttttg ggattacctg cgctgggtgc
agacactgtc tgagcaggtg 240caggaggagc tgctcagctc ccaggtcacc
caggaactga gggcgctgat ggacgagacc 300atgaaggagt tgaaggccta
caaatcggaa ctggaggaac aactgacccc ggtggcggag 360gagacgcggg
cacggctgtc caaggagctg caggcggcgc aggcccggct gggcgcggac
420atggaggacg tgtgcggccg cctggtgcag taccgcggcg aggtgcaggc
catgctcggc 480cagagcaccg aggagctgcg ggtgcgcctc gcctcccacc
tgcgcaagct gcgtaagcgg 540ctcctccgcg atgccgatga cctgcagaag
cgcctggcag tgtaccaggc cggggcccgc 600gagggcgccg agcgcggcct
cagcgccatc cgcgagcgcc tggggcccct ggtggaacag 660ggccgcgtgc
gggccgccac tgtgggctcc ctggccggcc agccgctaca ggagcgggcc
720caggcctggg gcgagcggct gcgcgcgcgg atggaggaga tgggcagccg
gacccgcgac 780cgcctggacg aggtgaagga gcaggtggcg gaggtgcgcg
ccaagctgga ggagcaggcc 840cagcagatac gcctgcaggc cgaggccttc
caggcccgcc tcaagagctg gttcgagccc 900ctggtggaag acatgcagcg
ccagtgggcc gggctggtgg agaaggtgca ggctgccgtg 960ggcaccagcg
ccgcccctgt gcccagcgac aatcactgaa cgccgaagcc tgcagccatg
1020cgaccccacg ccaccccgtg cctcctgcct ccgcgcagcc tgcagcggga
gaccctgtcc 1080ccgccccagc cgtcctcctg gggtggaccc tagtttaata
aagattcacc aagtttcacg 1140caaaaaa 114764317PRTHomo sapiens 64Met
Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 1 5 10
15Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu
20 25 30Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala
Leu 35 40 45Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser
Glu Gln 50 55 60Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu
Leu Arg Ala65 70 75 80Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala
Tyr Lys Ser Glu Leu 85 90 95Glu Glu Gln Leu Thr Pro Val Ala Glu Glu
Thr Arg Ala Arg Leu Ser 100 105 110Lys Glu Leu Gln Ala Ala Gln Ala
Arg Leu Gly Ala Asp Met Glu Asp 115 120 125Val Cys Gly Arg Leu Val
Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 130 135 140Gly Gln Ser Thr
Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg145 150 155 160Lys
Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 165 170
175Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu
180 185 190Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly
Arg Val 195 200 205Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro
Leu Gln Glu Arg 210 215 220Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala
Arg Met Glu Glu Met Gly225 230 235 240Ser Arg Thr Arg Asp Arg Leu
Asp Glu Val Lys Glu Gln Val Ala Glu 245 250 255Val Arg Ala Lys Leu
Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 260 265 270Glu Ala Phe
Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 275 280 285Asp
Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 290 295
300Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His305 310
315652493DNAHomo sapiens 65ggatcgattt gagtaagagc atagctgtcg
ggagagccca ggattcaaca cgggccttga 60gaaatgtggc tcttgtacct cctggtgccg
gccctgttct gcagggcagg aggctccatt 120cccatccctc agaagttatt
tggggaggtg acttcccctc tgttccccaa gccttacccc 180aacaactttg
aaacaaccac tgtgatcaca gtccccacgg gatacagggt gaagctcgtc
240ttccagcagt ttgacctgga gccttctgaa ggctgcttct atgattatgt
caagatctct 300gctgataaga aaagcctggg gaggttctgt gggcaactgg
gttctccact gggcaacccc 360ccgggaaaga aggaatttat gtcccaaggg
aacaagatgc tgctgacctt ccacacagac 420ttctccaacg aggagaatgg
gaccatcatg ttctacaagg gcttcctggc ctactaccaa 480gctgtggacc
ttgatgaatg tgcttcccgg agcaaatcag gggaggagga tccccagccc
540cagtgccagc acctgtgtca caactacgtt ggaggctact tctgttcctg
ccgtccaggc 600tatgagcttc aggaagacag gcattcctgc caggctgagt
gcagcagcga gctgtacacg 660gaggcatcag gctacatctc cagcctggag
taccctcggt cctacccccc tgacctgcgc 720tgcaactaca gcatccgggt
ggagcggggc ctcaccctgc acctcaagtt cctggagcct 780tttgatattg
atgaccacca gcaagtacac tgcccctatg accagctaca gatctatgcc
840aacgggaaga acattggcga gttctgtggg aagcaaaggc cccccgacct
cgacaccagc 900agcaatgctg tggatctgct gttcttcaca gatgagtcgg
gggacagccg gggctggaag 960ctgcgctaca ccaccgagat catcaagtgc
ccccagccca agaccctaga cgagttcacc 1020atcatccaga acctgcagcc
tcagtaccag ttccgtgact acttcattgc tacctgcaag 1080caaggctacc
agctcataga ggggaaccag gtgctgcatt ccttcacagc tgtctgccag
1140gatgatggca cgtggcatcg tgccatgccc agatgcaaga tcaaggactg
tgggcagccc 1200cgaaacctgc ctaatggtga cttccgttac accaccacaa
tgggagtgaa cacctacaag 1260gcccgtatcc agtactactg ccatgagcca
tattacaaga tgcagaccag agctggcagc 1320agggagtctg agcaaggggt
gtacacctgc acagcacagg gcatttggaa gaatgaacag 1380aagggagaga
agattcctcg gtgcttgcca gtgtgtggga agcccgtgaa ccccgtggaa
1440cagaggcagc gcataatcgg agggcaaaaa gccaagatgg gcaacttccc
ctggcaggtg 1500ttcaccaaca tccacgggcg cgggggcggg gccctgctgg
gcgaccgctg gatcctcaca 1560gctgcccaca ccctgtatcc caaggaacac
gaagcgcaaa gcaacgcctc tttggatgtg 1620ttcctgggcc acacaaatgt
ggaagagctc atgaagctag gaaatcaccc catccgcagg 1680gtcagcgtcc
acccggacta ccgtcaggat gagtcctaca attttgaggg ggacatcgcc
1740ctgctggagc tggaaaatag
tgtcaccctg ggtcccaacc tcctccccat ctgcctccct 1800gacaacgata
ccttctacga cctgggcttg atgggctatg tcagtggctt cggggtcatg
1860gaggagaaga ttgctcatga cctcaggttt gtccgtctgc ccgtagctaa
tccacaggcc 1920tgtgagaact ggctccgggg aaagaatagg atggatgtgt
tctctcaaaa catgttctgt 1980gctggacacc catctctaaa gcaggacgcc
tgccaggggg atagtggggg cgtttttgca 2040gtaagggacc cgaacactga
tcgctgggtg gccacgggca tcgtgtcctg gggcatcggg 2100tgcagcaggg
gctatggctt ctacaccaaa gtgctcaact acgtggactg gatcaagaaa
2160gagatggagg aggaggactg agcccagaat tcactaggtt cgaatccaga
gagcagtgtg 2220gaaaaaaaaa aaacaaaaaa caactgacca gttgttgata
accactaaga gtctctatta 2280aaattactga tgcagaaaga ccgtgtgtga
aattctcttt cctgtagtcc cattgatgta 2340ctttacctga aacaacccaa
aggccccttt ctttcttctg aggattgcag aggatatagt 2400tatcaatctc
tagttgtcac tttcctcttc cactttgata ccattgggtc attgaatata
2460actttttcca aataaagttt tatgagaaat gcc 249366705PRTHomo sapiens
66Met Trp Leu Leu Tyr Leu Leu Val Pro Ala Leu Phe Cys Arg Ala Gly 1
5 10 15Gly Ser Ile Pro Ile Pro Gln Lys Leu Phe Gly Glu Val Thr Ser
Pro 20 25 30Leu Phe Pro Lys Pro Tyr Pro Asn Asn Phe Glu Thr Thr Thr
Val Ile 35 40 45Thr Val Pro Thr Gly Tyr Arg Val Lys Leu Val Phe Gln
Gln Phe Asp 50 55 60Leu Glu Pro Ser Glu Gly Cys Phe Tyr Asp Tyr Val
Lys Ile Ser Ala65 70 75 80Asp Lys Lys Ser Leu Gly Arg Phe Cys Gly
Gln Leu Gly Ser Pro Leu 85 90 95Gly Asn Pro Pro Gly Lys Lys Glu Phe
Met Ser Gln Gly Asn Lys Met 100 105 110Leu Leu Thr Phe His Thr Asp
Phe Ser Asn Glu Glu Asn Gly Thr Ile 115 120 125Met Phe Tyr Lys Gly
Phe Leu Ala Tyr Tyr Gln Ala Val Asp Leu Asp 130 135 140Glu Cys Ala
Ser Arg Ser Lys Ser Gly Glu Glu Asp Pro Gln Pro Gln145 150 155
160Cys Gln His Leu Cys His Asn Tyr Val Gly Gly Tyr Phe Cys Ser Cys
165 170 175Arg Pro Gly Tyr Glu Leu Gln Glu Asp Arg His Ser Cys Gln
Ala Glu 180 185 190Cys Ser Ser Glu Leu Tyr Thr Glu Ala Ser Gly Tyr
Ile Ser Ser Leu 195 200 205Glu Tyr Pro Arg Ser Tyr Pro Pro Asp Leu
Arg Cys Asn Tyr Ser Ile 210 215 220Arg Val Glu Arg Gly Leu Thr Leu
His Leu Lys Phe Leu Glu Pro Phe225 230 235 240Asp Ile Asp Asp His
Gln Gln Val His Cys Pro Tyr Asp Gln Leu Gln 245 250 255Ile Tyr Ala
Asn Gly Lys Asn Ile Gly Glu Phe Cys Gly Lys Gln Arg 260 265 270Pro
Pro Asp Leu Asp Thr Ser Ser Asn Ala Val Asp Leu Leu Phe Phe 275 280
285Thr Asp Glu Ser Gly Asp Ser Arg Gly Trp Lys Leu Arg Tyr Thr Thr
290 295 300Glu Ile Ile Lys Cys Pro Gln Pro Lys Thr Leu Asp Glu Phe
Thr Ile305 310 315 320Ile Gln Asn Leu Gln Pro Gln Tyr Gln Phe Arg
Asp Tyr Phe Ile Ala 325 330 335Thr Cys Lys Gln Gly Tyr Gln Leu Ile
Glu Gly Asn Gln Val Leu His 340 345 350Ser Phe Thr Ala Val Cys Gln
Asp Asp Gly Thr Trp His Arg Ala Met 355 360 365Pro Arg Cys Lys Ile
Lys Asp Cys Gly Gln Pro Arg Asn Leu Pro Asn 370 375 380Gly Asp Phe
Arg Tyr Thr Thr Thr Met Gly Val Asn Thr Tyr Lys Ala385 390 395
400Arg Ile Gln Tyr Tyr Cys His Glu Pro Tyr Tyr Lys Met Gln Thr Arg
405 410 415Ala Gly Ser Arg Glu Ser Glu Gln Gly Val Tyr Thr Cys Thr
Ala Gln 420 425 430Gly Ile Trp Lys Asn Glu Gln Lys Gly Glu Lys Ile
Pro Arg Cys Leu 435 440 445Pro Val Cys Gly Lys Pro Val Asn Pro Val
Glu Gln Arg Gln Arg Ile 450 455 460Ile Gly Gly Gln Lys Ala Lys Met
Gly Asn Phe Pro Trp Gln Val Phe465 470 475 480Thr Asn Ile His Gly
Arg Gly Gly Gly Ala Leu Leu Gly Asp Arg Trp 485 490 495Ile Leu Thr
Ala Ala His Thr Leu Tyr Pro Lys Glu His Glu Ala Gln 500 505 510Ser
Asn Ala Ser Leu Asp Val Phe Leu Gly His Thr Asn Val Glu Glu 515 520
525Leu Met Lys Leu Gly Asn His Pro Ile Arg Arg Val Ser Val His Pro
530 535 540Asp Tyr Arg Gln Asp Glu Ser Tyr Asn Phe Glu Gly Asp Ile
Ala Leu545 550 555 560Leu Glu Leu Glu Asn Ser Val Thr Leu Gly Pro
Asn Leu Leu Pro Ile 565 570 575Cys Leu Pro Asp Asn Asp Thr Phe Tyr
Asp Leu Gly Leu Met Gly Tyr 580 585 590Val Ser Gly Phe Gly Val Met
Glu Glu Lys Ile Ala His Asp Leu Arg 595 600 605Phe Val Arg Leu Pro
Val Ala Asn Pro Gln Ala Cys Glu Asn Trp Leu 610 615 620Arg Gly Lys
Asn Arg Met Asp Val Phe Ser Gln Asn Met Phe Cys Ala625 630 635
640Gly His Pro Ser Leu Lys Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly
645 650 655Val Phe Ala Val Arg Asp Pro Asn Thr Asp Arg Trp Val Ala
Thr Gly 660 665 670Ile Val Ser Trp Gly Ile Gly Cys Ser Arg Gly Tyr
Gly Phe Tyr Thr 675 680 685Lys Val Leu Asn Tyr Val Asp Trp Ile Lys
Lys Glu Met Glu Glu Glu 690 695 700Asp70567777DNAHomo sapiens
67gctccgggct gaagattgct tctcttctct cctccaaggt ctagtgacgg agcccgcgcg
60cgcgccacca tgcggcagaa ggcggtatcc gttttcttgt gctacctgct gctcttcact
120tgcagtgggg tggaggcagg taagaaaaag tgctcggaga gctcggacag
cggctccggg 180ttctggaagg ccctgacctt catggccgtc ggaggaggac
tcgcagtcgc cgggctgccc 240gcgctgggct tcaccggcgc cggcatcgcg
gccaactcgg tggctgcctc gctgatgagc 300tggtctgcga tcctgaatgg
gggcggcgtg cccgccgggg ggctagtggc cacgctgcag 360agcctcgggg
ctggtggcag cagcgtcgtc ataggtaata ttggtgccct gatgcggtac
420gccacccaca agtatctcga tagtgaggag gatgaggagt agccagcagc
tcccagaacc 480tcttcttcct tcttggccta actcttccag ttaggatcta
gaactttgcc tttttttttt 540tttttttttt tttgagatgg gttctcacta
tattgtccag gctagagtgc agtggctatt 600cacagatgcg aacatagtac
actgcagcct ccaactccta gcctcaagtg atcctcctgt 660ctcaacctcc
caagtaggat tacaagcatg cgccgacgat gcccagaatc cagaactttg
720tctatcactc tccccaacaa cctagatgtg aaaacagaat aaacttcacc cagaaaa
77768130PRTHomo sapiens 68Met Arg Gln Lys Ala Val Ser Val Phe Leu
Cys Tyr Leu Leu Leu Phe 1 5 10 15Thr Cys Ser Gly Val Glu Ala Gly
Lys Lys Lys Cys Ser Glu Ser Ser 20 25 30Asp Ser Gly Ser Gly Phe Trp
Lys Ala Leu Thr Phe Met Ala Val Gly 35 40 45Gly Gly Leu Ala Val Ala
Gly Leu Pro Ala Leu Gly Phe Thr Gly Ala 50 55 60Gly Ile Ala Ala Asn
Ser Val Ala Ala Ser Leu Met Ser Trp Ser Ala65 70 75 80Ile Leu Asn
Gly Gly Gly Val Pro Ala Gly Gly Leu Val Ala Thr Leu 85 90 95Gln Ser
Leu Gly Ala Gly Gly Ser Ser Val Val Ile Gly Asn Ile Gly 100 105
110Ala Leu Met Arg Tyr Ala Thr His Lys Tyr Leu Asp Ser Glu Glu Asp
115 120 125Glu Glu 130692402DNAHomo sapiens 69agtctccgcc gccgccgtga
acatggagcc cccggacgca ccggcccagg cgcgcggggc 60cccgcggctg ctgttgctcg
cagtcctgct ggcggcgcac ccagatgccc aggcggaggt 120gcgcttgtct
gtacccccgc tggtggaggt gatgcgagga aagtctgtca ttctggactg
180cacccctacg ggaacccacg accattatat gctggaatgg ttccttaccg
accgctcggg 240agctcgcccc cgcctagcct cggctgagat gcagggctct
gagctccagg tcacaatgca 300cgacacccgg ggccgcagtc ccccatacca
gctggactcc caggggcgcc tggtgctggc 360tgaggcccag gtgggcgacg
agcgagacta cgtgtgcgtg gtgagggcag gggcggcagg 420cactgctgag
gccactgcgc ggctcaacgt gtttgcaaag ccagaggcca ctgaggtctc
480ccccaacaaa gggacactgt ctgtgatgga ggactctgcc caggagatcg
ccacctgcaa 540cagccggaac gggaacccgg cccccaagat cacgtggtat
cgcaacgggc agcgcctgga 600ggtgcccgta gagatgaacc cagagggcta
catgaccagc cgcacggtcc gggaggcctc 660gggcctgctc tccctcacca
gcaccctcta cctgcggctc cgcaaggatg accgagacgc 720cagcttccac
tgcgccgccc actacagcct gcccgagggc cgccacggcc gcctggacag
780ccccaccttc cacctcaccc tgcactatcc cacggagcac gtgcagttct
gggtgggcag 840cccgtccacc ccagcaggct gggtacgcga gggtgacact
gtccagctgc tctgccgggg 900ggacggcagc cccagcccgg agtatacgct
tttccgcctt caggatgagc aggaggaagt 960gctgaatgtg aatctcgagg
ggaacttgac cctggaggga gtgacccggg gccagagcgg 1020gacctatggc
tgcagagtgg aggattacga cgcggcagat gacgtgcagc tctccaagac
1080gctggagctg cgcgtggcct atctggaccc cctggagctc agcgagggga
aggtgctttc 1140cttacctcta aacagcagtg cagtcgtgaa ctgctccgtg
cacggcctgc ccacccctgc 1200cctacgctgg accaaggact ccactcccct
gggcgatggc cccatgctgt cgctcagttc 1260tatcaccttc gattccaatg
gcacctacgt atgtgaggcc tccctgccca cagtcccggt 1320cctcagccgc
acccagaact tcacgctgct ggtccaaggc tcgccagagc taaagacagc
1380ggaaatagag cccaaggcag atggcagctg gagggaagga gacgaagtca
cactcatctg 1440ctctgcccgc ggccatccag accccaaact cagctggagc
caattggggg gcagccccgc 1500agagccaatc cccggacggc agggttgggt
gagcagctct ctgaccctga aagtgaccag 1560cgccctgagc cgcgatggca
tctcctgtga agcctccaac ccccacggga acaagcgcca 1620tgtcttccac
ttcggcgccg tgagccccca gacctcccag gctggagtgg ccgtcatggc
1680cgtggccgtc agcgtgggcc tcctgctcct cgtcgttgct gtcttctact
gcgtgagacg 1740caaagggggc ccctgctgcc gccagcggcg ggagaagggg
gctccgccgc caggggagcc 1800agggctgagc cactcggggt cggagcaacc
agagcagacc ggccttctca tgggaggtgc 1860ctccggagga gccaggggtg
gcagcggggg cttcggagac gagtgctgag ccaagaacct 1920cctagaggct
gtccctggac ctggagctgc aggcatcaga gaaccagccc tgctcacgcc
1980atgcccgccc ccgccttccc tcttccctct tccctctccc tgcccagccc
tcccttcctt 2040cctctgccgg caaggcaggg acccacagtg gctgcctgcc
tccgggaggg aaggagaggg 2100agggtgggtg ggtgggaggg ggccttcctc
cagggaatgt gactctccca ggccccagaa 2160tagctcctgg acccaagccc
aaggcccagc ctgggacaag gctccgaggg tcggctggcc 2220ggagctattt
ttacctcccg cctcccctgc tggtcccccc acctgacgtc ttgctgcaga
2280gtctgacact ggattccccc ccctcacccc gcccctggtc ccactcctgc
ccccgcccta 2340cctccgcccc accccatcat ctgtggacac tggagtctgg
aataaatgct gtttgtcaca 2400tc 240270628PRTHomo sapiens 70Met Glu Pro
Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 1 5 10 15Leu
Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 20 25
30Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser
35 40 45Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met
Leu 50 55 60Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu
Ala Ser65 70 75 80Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met
His Asp Thr Arg 85 90 95Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln
Gly Arg Leu Val Leu 100 105 110Ala Glu Ala Gln Val Gly Asp Glu Arg
Asp Tyr Val Cys Val Val Arg 115 120 125Ala Gly Ala Ala Gly Thr Ala
Glu Ala Thr Ala Arg Leu Asn Val Phe 130 135 140Ala Lys Pro Glu Ala
Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser145 150 155 160Val Met
Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 165 170
175Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu
180 185 190Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser
Arg Thr 195 200 205Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser
Thr Leu Tyr Leu 210 215 220Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser
Phe His Cys Ala Ala His225 230 235 240Tyr Ser Leu Pro Glu Gly Arg
His Gly Arg Leu Asp Ser Pro Thr Phe 245 250 255His Leu Thr Leu His
Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 260 265 270Ser Pro Ser
Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 275 280 285Leu
Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 290 295
300Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu
Gly305 310 315 320Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser
Gly Thr Tyr Gly 325 330 335Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp
Asp Val Gln Leu Ser Lys 340 345 350Thr Leu Glu Leu Arg Val Ala Tyr
Leu Asp Pro Leu Glu Leu Ser Glu 355 360 365Gly Lys Val Leu Ser Leu
Pro Leu Asn Ser Ser Ala Val Val Asn Cys 370 375 380Ser Val His Gly
Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser385 390 395 400Thr
Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 405 410
415Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro
420 425 430Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly
Ser Pro 435 440 445Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp
Gly Ser Trp Arg 450 455 460Glu Gly Asp Glu Val Thr Leu Ile Cys Ser
Ala Arg Gly His Pro Asp465 470 475 480Pro Lys Leu Ser Trp Ser Gln
Leu Gly Gly Ser Pro Ala Glu Pro Ile 485 490 495Pro Gly Arg Gln Gly
Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 500 505 510Ser Ala Leu
Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 515 520 525Gly
Asn Lys Arg His Val Phe His Phe Gly Ala Val Ser Pro Gln Thr 530 535
540Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly
Leu545 550 555 560Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg
Arg Lys Gly Gly 565 570 575Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly
Ala Pro Pro Pro Gly Glu 580 585 590Pro Gly Leu Ser His Ser Gly Ser
Glu Gln Pro Glu Gln Thr Gly Leu 595 600 605Leu Met Gly Gly Ala Ser
Gly Gly Ala Arg Gly Gly Ser Gly Gly Phe 610 615 620Gly Asp Glu
Cys625715460DNAHomo sapiens 71cgggcccggt gctgaagggc agggaacaac
ttgatggtgc tactttgaac tgcttttctt 60ttctcctttt tgcacaaaga gtctcatgtc
tgatatttag acatgatgag ctttgtgcaa 120aaggggagct ggctacttct
cgctctgctt catcccacta ttattttggc acaacaggaa 180gctgttgaag
gaggatgttc ccatcttggt cagtcctatg cggatagaga tgtctggaag
240ccagaaccat gccaaatatg tgtctgtgac tcaggatccg ttctctgcga
tgacataata 300tgtgacgatc aagaattaga ctgccccaac ccagaaattc
catttggaga atgttgtgca 360gtttgcccac agcctccaac tgctcctact
cgccctccta atggtcaagg acctcaaggc 420cccaagggag atccaggccc
tcctggtatt cctgggagaa atggtgaccc tggtattcca 480ggacaaccag
ggtcccctgg ttctcctggc ccccctggaa tctgtgaatc atgccctact
540ggtcctcaga actattctcc ccagtatgat tcatatgatg tcaagtctgg
agtagcagta 600ggaggactcg caggctatcc tggaccagct ggccccccag
gccctcccgg tccccctggt 660acatctggtc atcctggttc ccctggatct
ccaggatacc aaggaccccc tggtgaacct 720gggcaagctg gtccttcagg
ccctccagga cctcctggtg ctataggtcc atctggtcct 780gctggaaaag
atggagaatc aggtagaccc ggacgacctg gagagcgagg attgcctgga
840cctccaggta tcaaaggtcc agctgggata cctggattcc ctggtatgaa
aggacacaga 900ggcttcgatg gacgaaatgg agaaaagggt gaaacaggtg
ctcctggatt aaagggtgaa 960aatggtcttc caggcgaaaa tggagctcct
ggacccatgg gtccaagagg ggctcctggt 1020gagcgaggac ggccaggact
tcctggggct gcaggtgctc ggggtaatga cggtgctcga 1080ggcagtgatg
gtcaaccagg ccctcctggt cctcctggaa ctgccggatt ccctggatcc
1140cctggtgcta agggtgaagt tggacctgca gggtctcctg gttcaaatgg
tgcccctgga 1200caaagaggag aacctggacc tcagggacac gctggtgctc
aaggtcctcc tggccctcct 1260gggattaatg gtagtcctgg tggtaaaggc
gaaatgggtc ccgctggcat tcctggagct 1320cctggactga tgggagcccg
gggtcctcca ggaccagccg gtgctaatgg tgctcctgga 1380ctgcgaggtg
gtgcaggtga gcctggtaag aatggtgcca aaggagagcc cggaccacgt
1440ggtgaacgcg gtgaggctgg tattccaggt gttccaggag ctaaaggcga
agatggcaag 1500gatggatcac ctggagaacc tggtgcaaat gggcttccag
gagctgcagg agaaaggggt 1560gcccctgggt tccgaggacc tgctggacca
aatggcatcc caggagaaaa gggtcctgct 1620ggagagcgtg gtgctccagg
ccctgcaggg cccagaggag ctgctggaga acctggcaga 1680gatggcgtcc
ctggaggtcc aggaatgagg ggcatgcccg gaagtccagg aggaccagga
1740agtgatggga aaccagggcc tcccggaagt caaggagaaa gtggtcgacc
aggtcctcct 1800gggccatctg gtccccgagg tcagcctggt gtcatgggct
tccccggtcc taaaggaaat 1860gatggtgctc ctggtaagaa tggagaacga
ggtggccctg gaggacctgg ccctcagggt 1920cctcctggaa agaatggtga
aactggacct caaggacccc cagggcctac tgggcctggt 1980ggtgacaaag
gagacacagg accccctggt ccacaaggat tacaaggctt gcctggtaca
2040ggtggtcctc caggagaaaa tggaaaacct ggggaaccag
gtccaaaggg tgatgccggt 2100gcacctggag ctccaggagg caagggtgat
gctggtgccc ctggtgaacg tggacctcct 2160ggattggcag gggccccagg
acttagaggt ggagctggtc cccctggtcc cgaaggagga 2220aagggtgctg
ctggtcctcc tgggccacct ggtgctgctg gtactcctgg tctgcaagga
2280atgcctggag aaagaggagg tcttggaagt cctggtccaa agggtgacaa
gggtgaacca 2340ggcggcccag gtgctgatgg tgtcccaggg aaagatggcc
caaggggtcc tactggtcct 2400attggtcctc ctggcccagc tggccagcct
ggagataagg gtgaaggtgg tgcccccgga 2460cttccaggta tagctggacc
tcgtggtagc cctggtgaga gaggtgaaac tggccctcca 2520ggacctgctg
gtttccctgg tgctcctgga cagaatggtg aacctggtgg taaaggagaa
2580agaggggctc cgggtgagaa aggtgaagga ggccctcctg gagttgcagg
accccctgga 2640ggttctggac ctgctggtcc tcctggtccc caaggtgtca
aaggtgaacg tggcagtcct 2700ggtggacctg gtgctgctgg cttccctggt
gctcgtggtc ttcctggtcc tcctggtagt 2760aatggtaacc caggaccccc
aggtcccagc ggttctccag gcaaggatgg gcccccaggt 2820cctgcgggta
acactggtgc tcctggcagc cctggagtgt ctggaccaaa aggtgatgct
2880ggccaaccag gagagaaggg atcgcctggt gcccagggcc caccaggagc
tccaggccca 2940cttgggattg ctgggatcac tggagcacgg ggtcttgcag
gaccaccagg catgccaggt 3000cctaggggaa gccctggccc tcagggtgtc
aagggtgaaa gtgggaaacc aggagctaac 3060ggtctcagtg gagaacgtgg
tccccctgga ccccagggtc ttcctggtct ggctggtaca 3120gctggtgaac
ctggaagaga tggaaaccct ggatcagatg gtcttccagg ccgagatgga
3180tctcctggtg gcaagggtga tcgtggtgaa aatggctctc ctggtgcccc
tggcgctcct 3240ggtcatccag gcccacctgg tcctgtcggt ccagctggaa
agagtggtga cagaggagaa 3300agtggccctg ctggccctgc tggtgctccc
ggtcctgctg gttcccgagg tgctcctggt 3360cctcaaggcc cacgtggtga
caaaggtgaa acaggtgaac gtggagctgc tggcatcaaa 3420ggacatcgag
gattccctgg taatccaggt gccccaggtt ctccaggccc tgctggtcag
3480cagggtgcaa tcggcagtcc aggacctgca ggccccagag gacctgttgg
acccagtgga 3540cctcctggca aagatggaac cagtggacat ccaggtccca
ttggaccacc agggcctcga 3600ggtaacagag gtgaaagagg atctgagggc
tccccaggcc acccagggca accaggccct 3660cctggacctc ctggtgcccc
tggtccttgc tgtggtggtg ttggagccgc tgccattgct 3720gggattggag
gtgaaaaagc tggcggtttt gccccgtatt atggagatga accaatggat
3780ttcaaaatca acaccgatga gattatgact tcactcaagt ctgttaatgg
acaaatagaa 3840agcctcatta gtcctgatgg ttctcgtaaa aaccccgcta
gaaactgcag agacctgaaa 3900ttctgccatc ctgaactcaa gagtggagaa
tactgggttg accctaacca aggatgcaaa 3960ttggatgcta tcaaggtatt
ctgtaatatg gaaactgggg aaacatgcat aagtgccaat 4020cctttgaatg
ttccacggaa acactggtgg acagattcta gtgctgagaa gaaacacgtt
4080tggtttggag agtccatgga tggtggtttt cagtttagct acggcaatcc
tgaacttcct 4140gaagatgtcc ttgatgtgca gctggcattc cttcgacttc
tctccagccg agcttcccag 4200aacatcacat atcactgcaa aaatagcatt
gcatacatgg atcaggccag tggaaatgta 4260aagaaggccc tgaagctgat
ggggtcaaat gaaggtgaat tcaaggctga aggaaatagc 4320aaattcacct
acacagttct ggaggatggt tgcacgaaac acactgggga atggagcaaa
4380acagtctttg aatatcgaac acgcaaggct gtgagactac ctattgtaga
tattgcaccc 4440tatgacattg gtggtcctga tcaagaattt ggtgtggacg
ttggccctgt ttgcttttta 4500taaaccaaac tctatctgaa atcccaacaa
aaaaaattta actccatatg tgttcctctt 4560gttctaatct tgtcaaccag
tgcaagtgac cgacaaaatt ccagttattt atttccaaaa 4620tgtttggaaa
cagtataatt tgacaaagaa aaatgatact tctctttttt tgctgttcca
4680ccaaatacaa ttcaaatgct ttttgtttta tttttttacc aattccaatt
tcaaaatgtc 4740tcaatggtgc tataataaat aaacttcaac actctttatg
ataacaacac tgtgttatat 4800tctttgaatc ctagcccatc tgcagagcaa
tgactgtgct caccagtaaa agataacctt 4860tctttctgaa atagtcaaat
acgaaattag aaaagccctc cctattttaa ctacctcaac 4920tggtcagaaa
cacagattgt attctatgag tcccagaaga tgaaaaaaat tttatacgtt
4980gataaaactt ataaatttca ttgattaatc tcctggaaga ttggtttaaa
aagaaaagtg 5040taatgcaaga atttaaagaa atatttttaa agccacaatt
attttaatat tggatatcaa 5100ctgcttgtaa aggtgctcct cttttttctt
gtcattgctg gtcaagatta ctaatatttg 5160ggaaggcttt aaagacgcat
gttatggtgc taatgtactt tcacttttaa actctagatc 5220agaattgttg
acttgcattc agaacataaa tgcacaaaat ctgtacatgt ctcccatcag
5280aaagattcat tggcatgcca cagggattct cctccttcat cctgtaaagg
tcaacaataa 5340aaaccaaatt atggggctgc ttttgtcaca ctagcataga
gaatgtgttg aaatttaact 5400ttgtaagctt gtatgtggtt gttgatcttt
tttttcctta cagacaccca taataaaata 5460721466PRTHomo sapiens 72Met
Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 1 5 10
15His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys
20 25 30Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro
Glu 35 40 45Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys
Asp Asp 50 55 60Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro
Glu Ile Pro65 70 75 80Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro
Pro Thr Ala Pro Thr 85 90 95Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly
Pro Lys Gly Asp Pro Gly 100 105 110Pro Pro Gly Ile Pro Gly Arg Asn
Gly Asp Pro Gly Ile Pro Gly Gln 115 120 125Pro Gly Ser Pro Gly Ser
Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 130 135 140Pro Thr Gly Pro
Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val145 150 155 160Lys
Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala 165 170
175Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly
180 185 190Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro
Gly Gln 195 200 205Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala
Ile Gly Pro Ser 210 215 220Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly
Arg Pro Gly Arg Pro Gly225 230 235 240Glu Arg Gly Leu Pro Gly Pro
Pro Gly Ile Lys Gly Pro Ala Gly Ile 245 250 255Pro Gly Phe Pro Gly
Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 260 265 270Gly Glu Lys
Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 275 280 285Leu
Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 290 295
300Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala
Arg305 310 315 320Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro
Gly Pro Pro Gly 325 330 335Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser
Pro Gly Ala Lys Gly Glu 340 345 350Val Gly Pro Ala Gly Ser Pro Gly
Ser Asn Gly Ala Pro Gly Gln Arg 355 360 365Gly Glu Pro Gly Pro Gln
Gly His Ala Gly Ala Gln Gly Pro Pro Gly 370 375 380Pro Pro Gly Ile
Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro385 390 395 400Ala
Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro 405 410
415Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly
420 425 430Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg
Gly Glu 435 440 445Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala
Lys Gly Glu Asp 450 455 460Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly
Ala Asn Gly Leu Pro Gly465 470 475 480Ala Ala Gly Glu Arg Gly Ala
Pro Gly Phe Arg Gly Pro Ala Gly Pro 485 490 495Asn Gly Ile Pro Gly
Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro 500 505 510Gly Pro Ala
Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly 515 520 525Val
Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly 530 535
540Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu
Ser545 550 555 560Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg
Gly Gln Pro Gly 565 570 575Val Met Gly Phe Pro Gly Pro Lys Gly Asn
Asp Gly Ala Pro Gly Lys 580 585 590Asn Gly Glu Arg Gly Gly Pro Gly
Gly Pro Gly Pro Gln Gly Pro Pro 595 600 605Gly Lys Asn Gly Glu Thr
Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly 610 615 620Pro Gly Gly Asp
Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu625 630 635 640Gln
Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 645 650
655Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly
660 665 670Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro
Gly Leu 675 680 685Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro
Pro Gly Pro Glu 690 695 700Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly
Pro Pro Gly Ala Ala Gly705 710 715 720Thr Pro Gly Leu Gln Gly Met
Pro Gly Glu Arg Gly Gly Leu Gly Ser 725 730 735Pro Gly Pro Lys Gly
Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp 740 745 750Gly Val Pro
Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly 755 760 765Pro
Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala 770 775
780Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu
Arg785 790 795 800Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro
Gly Ala Pro Gly 805 810 815Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu
Arg Gly Ala Pro Gly Glu 820 825 830Lys Gly Glu Gly Gly Pro Pro Gly
Val Ala Gly Pro Pro Gly Gly Ser 835 840 845Gly Pro Ala Gly Pro Pro
Gly Pro Gln Gly Val Lys Gly Glu Arg Gly 850 855 860Ser Pro Gly Gly
Pro Gly Ala Ala Gly Phe Pro Gly Ala Arg Gly Leu865 870 875 880Pro
Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro Gly Pro Ser 885 890
895Gly Ser Pro Gly Lys Asp Gly Pro Pro Gly Pro Ala Gly Asn Thr Gly
900 905 910Ala Pro Gly Ser Pro Gly Val Ser Gly Pro Lys Gly Asp Ala
Gly Gln 915 920 925Pro Gly Glu Lys Gly Ser Pro Gly Ala Gln Gly Pro
Pro Gly Ala Pro 930 935 940Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly
Ala Arg Gly Leu Ala Gly945 950 955 960Pro Pro Gly Met Pro Gly Pro
Arg Gly Ser Pro Gly Pro Gln Gly Val 965 970 975Lys Gly Glu Ser Gly
Lys Pro Gly Ala Asn Gly Leu Ser Gly Glu Arg 980 985 990Gly Pro Pro
Gly Pro Gln Gly Leu Pro Gly Leu Ala Gly Thr Ala Gly 995 1000
1005Glu Pro Gly Arg Asp Gly Asn Pro Gly Ser Asp Gly Leu Pro Gly Arg
1010 1015 1020Asp Gly Ser Pro Gly Gly Lys Gly Asp Arg Gly Glu Asn
Gly Ser Pro1025 1030 1035 1040Gly Ala Pro Gly Ala Pro Gly His Pro
Gly Pro Pro Gly Pro Val Gly 1045 1050 1055Pro Ala Gly Lys Ser Gly
Asp Arg Gly Glu Ser Gly Pro Ala Gly Pro 1060 1065 1070Ala Gly Ala
Pro Gly Pro Ala Gly Ser Arg Gly Ala Pro Gly Pro Gln 1075 1080
1085Gly Pro Arg Gly Asp Lys Gly Glu Thr Gly Glu Arg Gly Ala Ala Gly
1090 1095 1100Ile Lys Gly His Arg Gly Phe Pro Gly Asn Pro Gly Ala
Pro Gly Ser1105 1110 1115 1120Pro Gly Pro Ala Gly Gln Gln Gly Ala
Ile Gly Ser Pro Gly Pro Ala 1125 1130 1135Gly Pro Arg Gly Pro Val
Gly Pro Ser Gly Pro Pro Gly Lys Asp Gly 1140 1145 1150Thr Ser Gly
His Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly Asn 1155 1160
1165Arg Gly Glu Arg Gly Ser Glu Gly Ser Pro Gly His Pro Gly Gln Pro
1170 1175 1180Gly Pro Pro Gly Pro Pro Gly Ala Pro Gly Pro Cys Cys
Gly Gly Val1185 1190 1195 1200Gly Ala Ala Ala Ile Ala Gly Ile Gly
Gly Glu Lys Ala Gly Gly Phe 1205 1210 1215Ala Pro Tyr Tyr Gly Asp
Glu Pro Met Asp Phe Lys Ile Asn Thr Asp 1220 1225 1230Glu Ile Met
Thr Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser Leu 1235 1240
1245Ile Ser Pro Asp Gly Ser Arg Lys Asn Pro Ala Arg Asn Cys Arg Asp
1250 1255 1260Leu Lys Phe Cys His Pro Glu Leu Lys Ser Gly Glu Tyr
Trp Val Asp1265 1270 1275 1280Pro Asn Gln Gly Cys Lys Leu Asp Ala
Ile Lys Val Phe Cys Asn Met 1285 1290 1295Glu Thr Gly Glu Thr Cys
Ile Ser Ala Asn Pro Leu Asn Val Pro Arg 1300 1305 1310Lys His Trp
Trp Thr Asp Ser Ser Ala Glu Lys Lys His Val Trp Phe 1315 1320
1325Gly Glu Ser Met Asp Gly Gly Phe Gln Phe Ser Tyr Gly Asn Pro Glu
1330 1335 1340Leu Pro Glu Asp Val Leu Asp Val Gln Leu Ala Phe Leu
Arg Leu Leu1345 1350 1355 1360Ser Ser Arg Ala Ser Gln Asn Ile Thr
Tyr His Cys Lys Asn Ser Ile 1365 1370 1375Ala Tyr Met Asp Gln Ala
Ser Gly Asn Val Lys Lys Ala Leu Lys Leu 1380 1385 1390Met Gly Ser
Asn Glu Gly Glu Phe Lys Ala Glu Gly Asn Ser Lys Phe 1395 1400
1405Thr Tyr Thr Val Leu Glu Asp Gly Cys Thr Lys His Thr Gly Glu Trp
1410 1415 1420Ser Lys Thr Val Phe Glu Tyr Arg Thr Arg Lys Ala Val
Arg Leu Pro1425 1430 1435 1440Ile Val Asp Ile Ala Pro Tyr Asp Ile
Gly Gly Pro Asp Gln Glu Phe 1445 1450 1455Gly Val Asp Val Gly Pro
Val Cys Phe Leu 1460 1465731051DNAHomo sapiens 73cgcggagtct
gagcggcgct cgtcccgtcc caaggccgac gccagcacgc cgtcatggcc 60cccgcagcgg
cgacgggggg cagcaccctg cccagtggct tctcggtctt caccaccttg
120cccgacttgc tcttcatctt tgagtttatc ttcgggggcc tggtgtggat
cctggtggcc 180tcctccctgg tgccctggcc cctggtccag ggctgggtga
tgttcgtgtc tgtgttctgc 240ttcgtggcca ccaccacctt gatcatcctg
tacataattg gagcccacgg tggagagact 300tcctgggtca ccttggacgc
agcctaccac tgcaccgctg ccctctttta cctcagcgcc 360tcagtcctgg
aggccctggc caccatcacg atgcaagacg gcttcaccta caggcactac
420catgaaaaca ttgctgccgt ggtgttctcc tacatagcca ctctgctcta
cgtggtccat 480gcggtgttct ctttaatcag atggaagtct tcataaagcc
gcagtagaac ttgagctgaa 540aacccagatg gtgttaactg gccgccccac
tttccggcat aactttttag aaaacagaaa 600tgcccttgat ggtggaaaaa
agaaaacaac caccccccca ctgcccaaaa aaaaaagccc 660tgccctgttg
ctcgtgggtg ctgtgtttac tctcccgtgt gccttcgcgt ccgggttggg
720agcttgctgt gtctaacctc caactgctgt gctgtctgct agggtcacct
cctgtttgtg 780aaaggggacc ttcttgttcg ggggtgggaa gtggcgaccg
tgacctgaga aggaaagaaa 840gatcctctgc tgacccctgg agcagctctc
gagaactacc tgttggtatt gtccacaagc 900tctcccgagc gccccatctt
gtgccatgtt ttaagtcttc atggatgttc tgcatgtcat 960ggggactaaa
actcacccaa cagatctttc cagaggtcca tggtggaaga cgataaccct
1020gtgaaatact ttataaaatg tcttaatgtt c 105174153PRTHomo sapiens
74Met Ala Pro Ala Ala Ala Thr Gly Gly Ser Thr Leu Pro Ser Gly Phe 1
5 10 15Ser Val Phe Thr Thr Leu Pro Asp Leu Leu Phe Ile Phe Glu Phe
Ile 20 25 30Phe Gly Gly Leu Val Trp Ile Leu Val Ala Ser Ser Leu Val
Pro Trp 35 40 45Pro Leu Val Gln Gly Trp Val Met Phe Val Ser Val Phe
Cys Phe Val 50 55 60Ala Thr Thr Thr Leu Ile Ile Leu Tyr Ile Ile Gly
Ala His Gly Gly65 70 75 80Glu Thr Ser Trp Val Thr Leu Asp Ala Ala
Tyr His Cys Thr Ala Ala 85 90 95Leu Phe Tyr Leu Ser Ala Ser Val Leu
Glu Ala Leu Ala Thr Ile Thr 100 105 110Met Gln Asp Gly Phe Thr Tyr
Arg His Tyr His Glu Asn Ile Ala Ala 115 120 125Val Val Phe Ser Tyr
Ile Ala Thr Leu Leu Tyr Val Val His Ala Val 130 135 140Phe Ser Leu
Ile Arg Trp Lys Ser Ser145 150755416DNAHomo sapiens 75gtgtcccata
gtgtttccaa acttggaaag ggcgggggag ggcgggagga tgcggagggc 60ggaggtatgc
agacaacgag tcagagtttc cccttgaaag cctcaaaagt gtccacgtcc
120tcaaaaagaa tggaaccaat ttaagaagcc agccccgtgg ccacgtccct
tcccccattc 180gggccctcct ctgcgccccc gcaggctcct cccagctgtg
gctgcccggg cccccagccc 240cagccctccc attggtggag gcccttttgg
aggcacccta gggccaggga aacttttgcc 300gtataaatag ggcagatccg
ggatttgtta ttttagcacc acggcagcag gaggtttcgg 360ctaagttgga
ggtactggcc acgactgcat gcccgcgccc gccatgtgat acctccgccg
420gtgacccagg gctctgcgac acaaggagtc gcatgtctaa gtgctagaca
tgctcagctt 480tgtggatacg cggactttgt tgctgcttgc agtaacctta
tgcctagcaa catgccaatc 540tttacaagag gaaactgtaa gaaagggccc
agccggagat agaggaccac gtggagaaag 600gggtccacca ggccccccag
gcagagatgg tgaagatggt
cccacaggcc ctcctggtcc 660acctggtcct cctggccccc ctggtctcgg
tgggaacttt gctgctcagt atgatggaaa 720aggagttgga cttggccctg
gaccaatggg cttaatggga cctagaggcc cacctggtgc 780agctggagcc
ccaggccctc aaggtttcca aggacctgct ggtgagcctg gtgaacctgg
840tcaaactggt cctgcaggtg ctcgtggtcc agctggccct cctggcaagg
ctggtgaaga 900tggtcaccct ggaaaacccg gacgacctgg tgagagagga
gttgttggac cacagggtgc 960tcgtggtttc cctggaactc ctggacttcc
tggcttcaaa ggcattaggg gacacaatgg 1020tctggatgga ttgaagggac
agcccggtgc tcctggtgtg aagggtgaac ctggtgcccc 1080tggtgaaaat
ggaactccag gtcaaacagg agcccgtggt cttcctggtg agagaggacg
1140tgttggtgcc cctggtccag ctggtgcccg tggaagtgat ggaagtgtgg
gtcccgtagg 1200tcctgctggt cctaatgggt ctgctggccc tccaggtttc
ccaggtgccc ctggtcccaa 1260gggtgaaatt ggagctgttg gtaacgctgg
tcctactgga cccgccggtc cccgtggtga 1320agtgggtctt ccaggcctct
ccggccccgt tggacctcct ggtaatcctg gagcaaacgg 1380ccttactggt
gccaagggtg ctgctggcct tcccggcgtt gctggggctc ccggcctccc
1440tggaccccgc ggtattcctg gccctcctgg tgctgccggt actactggtg
ccagaggact 1500tgttggtgag cctggtccag ctggctccaa aggagagagc
ggtaacaagg gtgagcccgg 1560ctccgctggt ccccaaggtc ctcctggtcc
cagtggtgaa gaaggaaaga gaggccctaa 1620tggggaagct ggatctgccg
gccctccagg acctcctggg ctgagaggta gtcctggttc 1680tcgtggtctt
cctggagctg atggcagagc tggcgtcatg ggccctcctg gtagtcgtgg
1740tgcaagtggc cctgctggag tccgaggacc taatggagat gctggtcgcc
ctggggagcc 1800tggtctcatg ggacccagag gtcttcctgg ttcccctgga
aatatcggcc ccgctggaaa 1860agaaggtcct gtcggcctcc ctggcatcga
cggcaggcct ggcccaattg gccccgttgg 1920agcaagagga gagcctggca
acattggatt ccctggaccc aaaggcccca ctggtgaccc 1980tggcaaaaac
ggtgataaag gtcatgctgg tcttgctggt gctcggggtg ctccaggtcc
2040tgatggaaac aatggtgctc agggacctcc tggaccacag ggtgttcaag
gtggaaaagg 2100tgaacagggt cccgctggtc ctccaggctt ccagggtctg
cctggcccct caggtcccgc 2160tggtgaagtt ggcaaaccag gagaaagggg
tctccatggt gagtttggtc tccctggtcc 2220tgctggtcca agaggggaac
gcggtccccc aggtgagagt ggtgctgccg gtcctactgg 2280tcctattgga
agccgaggtc cttctggacc cccagggcct gatggaaaca agggtgaacc
2340tggtgtggtt ggtgctgtgg gcactgctgg tccatctggt cctagtggac
tcccaggaga 2400gaggggtgct gctggcatac ctggaggcaa gggagaaaag
ggtgaacctg gtctcagagg 2460tgaaattggt aaccctggca gagatggtgc
tcgtggtgct catggtgctg taggtgcccc 2520tggtcctgct ggagccacag
gtgaccgggg cgaagctggg gctgctggtc ctgctggtcc 2580tgctggtcct
cggggaagcc ctggtgaacg tggcgaggtc ggtcctgctg gccccaacgg
2640atttgctggt ccggctggtg ctgctggtca accgggtgct aaaggagaaa
gaggaggcaa 2700agggcctaag ggtgaaaacg gtgttgttgg tcccacaggc
cccgttggag ctgctggccc 2760agctggtcca aatggtcccc ccggtcctgc
tggaagtcgt ggtgatggag gcccccctgg 2820tatgactggt ttccctggtg
ctgctggacg gactggtccc ccaggaccct ctggtatttc 2880tggccctcct
ggtccccctg gtcctgctgg gaaagaaggg cttcgtggtc ctcgtggtga
2940ccaaggtcca gttggccgaa ctggagaagt aggtgcagtt ggtccccctg
gcttcgctgg 3000tgagaagggt ccctctggag aggctggtac tgctggacct
cctggcactc caggtcctca 3060gggtcttctt ggtgctcctg gtattctggg
tctccctggc tcgagaggtg aacgtggtct 3120acctggtgtt gctggtgctg
tgggtgaacc tggtcctctt ggcattgccg gccctcctgg 3180ggcccgtggt
cctcctggtg ctgtgggtag tcctggagtc aacggtgctc ctggtgaagc
3240tggtcgtgat ggcaaccctg ggaacgatgg tcccccaggt cgcgatggtc
aacccggaca 3300caagggagag cgcggttacc ctggcaatat tggtcccgtt
ggtgctgcag gtgcacctgg 3360tcctcatggc cccgtgggtc ctgctggcaa
acatggaaac cgtggtgaaa ctggtccttc 3420tggtcctgtt ggtcctgctg
gtgctgttgg cccaagaggt cctagtggcc cacaaggcat 3480tcgtggcgat
aagggagagc ccggtgaaaa ggggcccaga ggtcttcctg gcttcaaggg
3540acacaatgga ttgcaaggtc tgcctggtat cgctggtcac catggtgatc
aaggtgctcc 3600tggctccgtg ggtcctgctg gtcctagggg ccctgctggt
ccttctggcc ctgctggaaa 3660agatggtcgc actggacatc ctggtacggt
tggacctgct ggcattcgag gccctcaggg 3720tcaccaaggc cctgctggcc
cccctggtcc ccctggccct cctggacctc caggtgtaag 3780cggtggtggt
tatgactttg gttacgatgg agacttctac agggctgacc agcctcgctc
3840agcaccttct ctcagaccca aggactatga agttgatgct actctgaagt
ctctcaacaa 3900ccagattgag acccttctta ctcctgaagg ctctagaaag
aacccagctc gcacatgccg 3960tgacttgaga ctcagccacc cagagtggag
cagcggttac tactggattg accccaacca 4020aggatgcact atggaagcca
tcaaagtata ctgtgatttc cctaccggcg aaacctgtat 4080ccgggcccaa
cctgaaaaca tcccagccaa gaactggtat aggagctcca aggacaagaa
4140acacgtctgg ctaggagaaa ctatcaatgc tggcagccag tttgaatata
atgttgaagg 4200agtgacttcc aaggaaatgg ctacccaact tgccttcatg
cgcctgctgg ccaactatgc 4260ctctcagaac atcacctacc actgcaagaa
cagcattgca tacatggatg aggagactgg 4320caacctgaaa aaggctgtca
ttctacaggg ctctaatgat gttgaacttg ttgctgaggg 4380caacagcagg
ttcacttaca ctgttcttgt agatggctgc tctaaaaaga caaatgaatg
4440gggaaagaca atcattgaat acaaaacaaa taagccatca cgcctgccct
tccttgatat 4500tgcacctttg gacatcggtg gtgctgacca tgaattcttt
gtggacattg gcccagtctg 4560tttcaaataa atgaactcaa tctaaattaa
aaaagaaaga aatttgaaaa aactttctct 4620ttgccatttc ttcttcttct
tttttaactg aaagctgaat ccttccattt cttctgcaca 4680tctacttgct
taaattgtgg gcaaaagaga aaaagaagga ttgatcagag cattgtgcaa
4740tacagtttca ttaactcctt cccccgctcc cccaaaaatt tgaatttttt
tttcaacact 4800cttacacctg ttatggaaaa tgtcaacctt tgtaagaaaa
ccaaaataaa aattgaaaaa 4860taaaaaccat aaacatttgc accacttgtg
gcttttgaat atcttccaca gagggaagtt 4920taaaacccaa acttccaaag
gtttaaacta cctcaaaaca ctttcccatg agtgtgatcc 4980acattgttag
gtgctgacct agacagagat gaactgaggt ccttgttttg ttttgttcat
5040aatacaaagg tgctaattaa tagtatttca gatacttgaa gaatgttgat
ggtgctagaa 5100gaatttgaga agaaatactc ctgtattgag ttgtatcgtg
tggtgtattt tttaaaaaat 5160ttgatttagc attcatattt tccatcttat
tcccaattaa aagtatgcag attatttgcc 5220caaagttgtc ctcttcttca
gattcagcat ttgttctttg ccagtctcat tttcatcttc 5280ttccatggtt
ccacagaagc tttgtttctt gggcaagcag aaaaattaaa ttgtacctat
5340tttgtatatg tgagatgttt aaataaattg tgaaaaaaat gaaataaagc
atgtttggtt 5400ttccaaaaga acatat 5416761366PRTHomo sapiens 76Met
Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 1 5 10
15Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys
20 25 30Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro
Gly 35 40 45Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro
Gly Pro 50 55 60Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe
Ala Ala Gln65 70 75 80Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly
Pro Met Gly Leu Met 85 90 95Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly
Ala Pro Gly Pro Gln Gly 100 105 110Phe Gln Gly Pro Ala Gly Glu Pro
Gly Glu Pro Gly Gln Thr Gly Pro 115 120 125Ala Gly Ala Arg Gly Pro
Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 130 135 140Gly His Pro Gly
Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly145 150 155 160Pro
Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 165 170
175Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro
180 185 190Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu
Asn Gly 195 200 205Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly
Glu Arg Gly Arg 210 215 220Val Gly Ala Pro Gly Pro Ala Gly Ala Arg
Gly Ser Asp Gly Ser Val225 230 235 240Gly Pro Val Gly Pro Ala Gly
Pro Asn Gly Ser Ala Gly Pro Pro Gly 245 250 255Phe Pro Gly Ala Pro
Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 260 265 270Ala Gly Pro
Thr Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 275 280 285Gly
Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 290 295
300Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly
Ala305 310 315 320Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro
Pro Gly Ala Ala 325 330 335Gly Thr Thr Gly Ala Arg Gly Leu Val Gly
Glu Pro Gly Pro Ala Gly 340 345 350Ser Lys Gly Glu Ser Gly Asn Lys
Gly Glu Pro Gly Ser Ala Gly Pro 355 360 365Gln Gly Pro Pro Gly Pro
Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 370 375 380Gly Glu Ala Gly
Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly385 390 395 400Ser
Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 405 410
415Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg
420 425 430Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu
Met Gly 435 440 445Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly
Pro Ala Gly Lys 450 455 460Glu Gly Pro Val Gly Leu Pro Gly Ile Asp
Gly Arg Pro Gly Pro Ile465 470 475 480Gly Pro Val Gly Ala Arg Gly
Glu Pro Gly Asn Ile Gly Phe Pro Gly 485 490 495Pro Lys Gly Pro Thr
Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 500 505 510Ala Gly Leu
Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 515 520 525Gly
Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 530 535
540Glu Gln Gly Pro Ala Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly
Pro545 550 555 560Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu
Arg Gly Leu His 565 570 575Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly
Pro Arg Gly Glu Arg Gly 580 585 590Pro Pro Gly Glu Ser Gly Ala Ala
Gly Pro Thr Gly Pro Ile Gly Ser 595 600 605Arg Gly Pro Ser Gly Pro
Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 610 615 620Gly Val Val Gly
Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly625 630 635 640Leu
Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 645 650
655Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp
660 665 670Gly Ala Arg Gly Ala His Gly Ala Val Gly Ala Pro Gly Pro
Ala Gly 675 680 685Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly
Pro Ala Gly Pro 690 695 700Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg
Gly Glu Val Gly Pro Ala705 710 715 720Gly Pro Asn Gly Phe Ala Gly
Pro Ala Gly Ala Ala Gly Gln Pro Gly 725 730 735Ala Lys Gly Glu Arg
Gly Gly Lys Gly Pro Lys Gly Glu Asn Gly Val 740 745 750Val Gly Pro
Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 755 760 765Gly
Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 770 775
780Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly
Pro785 790 795 800Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro
Ala Gly Lys Glu 805 810 815Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly
Pro Val Gly Arg Thr Gly 820 825 830Glu Val Gly Ala Val Gly Pro Pro
Gly Phe Ala Gly Glu Lys Gly Pro 835 840 845Ser Gly Glu Ala Gly Thr
Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 850 855 860Gly Leu Leu Gly
Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly865 870 875 880Glu
Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 885 890
895Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val
900 905 910Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg
Asp Gly 915 920 925Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly
Gln Pro Gly His 930 935 940Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile
Gly Pro Val Gly Ala Ala945 950 955 960Gly Ala Pro Gly Pro His Gly
Pro Val Gly Pro Ala Gly Lys His Gly 965 970 975Asn Arg Gly Glu Thr
Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 980 985 990Val Gly Pro
Arg Gly Pro Ser Gly Pro Gln Gly Ile Arg Gly Asp Lys 995 1000
1005Gly Glu Pro Gly Glu Lys Gly Pro Arg Gly Leu Pro Gly Phe Lys Gly
1010 1015 1020His Asn Gly Leu Gln Gly Leu Pro Gly Ile Ala Gly His
His Gly Asp1025 1030 1035 1040Gln Gly Ala Pro Gly Ser Val Gly Pro
Ala Gly Pro Arg Gly Pro Ala 1045 1050 1055Gly Pro Ser Gly Pro Ala
Gly Lys Asp Gly Arg Thr Gly His Pro Gly 1060 1065 1070Thr Val Gly
Pro Ala Gly Ile Arg Gly Pro Gln Gly His Gln Gly Pro 1075 1080
1085Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Ser
1090 1095 1100Gly Gly Gly Tyr Asp Phe Gly Tyr Asp Gly Asp Phe Tyr
Arg Ala Asp1105 1110 1115 1120Gln Pro Arg Ser Ala Pro Ser Leu Arg
Pro Lys Asp Tyr Glu Val Asp 1125 1130 1135Ala Thr Leu Lys Ser Leu
Asn Asn Gln Ile Glu Thr Leu Leu Thr Pro 1140 1145 1150Glu Gly Ser
Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Arg Leu 1155 1160
1165Ser His Pro Glu Trp Ser Ser Gly Tyr Tyr Trp Ile Asp Pro Asn Gln
1170 1175 1180Gly Cys Thr Met Glu Ala Ile Lys Val Tyr Cys Asp Phe
Pro Thr Gly1185 1190 1195 1200Glu Thr Cys Ile Arg Ala Gln Pro Glu
Asn Ile Pro Ala Lys Asn Trp 1205 1210 1215Tyr Arg Ser Ser Lys Asp
Lys Lys His Val Trp Leu Gly Glu Thr Ile 1220 1225 1230Asn Ala Gly
Ser Gln Phe Glu Tyr Asn Val Glu Gly Val Thr Ser Lys 1235 1240
1245Glu Met Ala Thr Gln Leu Ala Phe Met Arg Leu Leu Ala Asn Tyr Ala
1250 1255 1260Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Ile Ala
Tyr Met Asp1265 1270 1275 1280Glu Glu Thr Gly Asn Leu Lys Lys Ala
Val Ile Leu Gln Gly Ser Asn 1285 1290 1295Asp Val Glu Leu Val Ala
Glu Gly Asn Ser Arg Phe Thr Tyr Thr Val 1300 1305 1310Leu Val Asp
Gly Cys Ser Lys Lys Thr Asn Glu Trp Gly Lys Thr Ile 1315 1320
1325Ile Glu Tyr Lys Thr Asn Lys Pro Ser Arg Leu Pro Phe Leu Asp Ile
1330 1335 1340Ala Pro Leu Asp Ile Gly Gly Ala Asp His Glu Phe Phe
Val Asp Ile1345 1350 1355 1360Gly Pro Val Cys Phe Lys
1365771082DNAHomo sapiens 77agctcccttt agcgagtcct tcttttcctg
actgcagctc ttttcatttt gccatccttt 60tccagcacca tgatggttct gcaggtttct
gcggcccccc ggacagtggc tctgacggcg 120ttactgatgg tgctgctcac
atctgtggtc cagggcaggg ccactccaga gaattacctt 180ttccagggac
ggcaggaatg ctacgcgttt aatgggacac agcgcttcct ggagagatac
240atctacaacc gggaggagtt cgcgcgcttc gacagcgacg tgggggagtt
ccgggcggtg 300acggagctgg ggcggcctgc tgcggagtac tggaacagcc
agaaggacat cctggaggag 360aagcgggcag tgccggacag gatgtgcaga
cacaactacg agctgggcgg gcccatgacc 420ctgcagcgcc gagtccagcc
tagggtgaat gtttccccct ccaagaaggg gcccttgcag 480caccacaacc
tgcttgtctg ccacgtgacg gatttctacc caggcagcat tcaagtccga
540tggttcctga atggacagga ggaaacagct ggggtcgtgt ccaccaacct
gatccgtaat 600ggagactgga ccttccagat cctggtgatg ctggaaatga
ccccccagca gggagatgtc 660tacacctgcc aagtggagca caccagcctg
gatagtcctg tcaccgtgga gtggaaggca 720cagtctgatt ctgcccggag
taagacattg acgggagctg ggggcttcgt gctggggctc 780atcatctgtg
gagtgggcat cttcatgcac aggaggagca agaaagttca acgaggatct
840gcataaacag ggttcctgag ctcactgaaa agactattgt gccttaggaa
aagcatttgc 900tgtgtttcgt tagcatctgg ctccaggaca gaccttcaac
ttccaaattg atactgctgc 960caagaagttg ctctgaagtc agtttctatc
attctgctct ttgattcaaa gcactgtttc 1020tctcactggg cctccaacca
tgttcccttc ttcttagcac cacaaataat caaaacccaa 1080ca 108278258PRTHomo
sapiens 78Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala
Leu Thr 1 5 10 15Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln
Gly Arg Ala Thr 20 25 30Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu
Cys Tyr Ala Phe Asn 35 40 45Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile
Tyr Asn Arg Glu Glu Phe 50 55 60Ala Arg Phe Asp Ser Asp Val Gly Glu
Phe Arg Ala Val Thr Glu Leu65 70 75 80Gly Arg Pro Ala Ala Glu Tyr
Trp Asn Ser Gln Lys Asp Ile Leu Glu 85 90 95Glu Lys Arg Ala Val Pro
Asp Arg Met Cys Arg His Asn Tyr Glu Leu 100 105 110Gly Gly Pro Met
Thr Leu
Gln Arg Arg Val Gln Pro Arg Val Asn Val 115 120 125Ser Pro Ser Lys
Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 130 135 140His Val
Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu145 150 155
160Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg
165 170 175Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met
Thr Pro 180 185 190Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His
Thr Ser Leu Asp 195 200 205Ser Pro Val Thr Val Glu Trp Lys Ala Gln
Ser Asp Ser Ala Arg Ser 210 215 220Lys Thr Leu Thr Gly Ala Gly Gly
Phe Val Leu Gly Leu Ile Ile Cys225 230 235 240Gly Val Gly Ile Phe
Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 245 250 255Ser
Ala79996DNAHomo sapiens 79gtggaattca tggcatctac ttcgtatgac
tattgcagag tgcccatgga agacggggat 60aagcgctgta agcttctgct ggggatagga
attctggtgc tcctgatcat cgtgattctg 120ggggtgccct tgattatctt
caccatcaag gccaacagcg aggcctgccg ggacggcctt 180cgggcagtga
tggagtgtcg caatgtcacc catctcctgc aacaagagct gaccgaggcc
240cagaagggct ttcaggatgt ggaggcccag gccgccacct gcaaccacac
tgtgatggcc 300ctaatggctt ccctggatgc agagaaggcc caaggacaaa
agaaagtgga ggagcttgag 360ggagagatca ctacattaaa ccataagctt
caggacgcgt ctgcagaggt ggagcgactg 420agaagagaaa accaggtctt
aagcgtgaga atcgcggaca agaagtacta ccccagctcc 480caggactcca
gctccgctgc ggcgccccag ctgctgattg tgctgctggg cctcagcgct
540ctgctgcagt gagatcccag gaagctggca catcttggaa ggtccgtcct
gctcggcttt 600tcgcttgaac attcccttga tctcatcagt tctgagcggg
tcatggggca acacggttag 660cggggagagc acggggtagc cggagaaggg
cctctggagc aggtctggag gggccatggg 720gcagtcctgg gtgtggggac
acagtcgggt tgacccaggg ctgtctccct ccagagcctc 780cctccggaca
atgagtcccc cctcttgtct cccaccctga gattgggcat ggggtgcggt
840gtggggggca tgtgctgcct gttgttatgg gttttttttg cggggggggt
tgcttttttc 900tggggtcttt gagctccaaa aaataaacac ttcctttgag
ggagagcaaa aaaaaaaaaa 960aaaaaaaaaa aaaaaaaaaa aaagaattcc accaca
99680180PRTHomo sapiens 80Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg
Val Pro Met Glu Asp Gly 1 5 10 15Asp Lys Arg Cys Lys Leu Leu Leu
Gly Ile Gly Ile Leu Val Leu Leu 20 25 30Ile Ile Val Ile Leu Gly Val
Pro Leu Ile Ile Phe Thr Ile Lys Ala 35 40 45Asn Ser Glu Ala Cys Arg
Asp Gly Leu Arg Ala Val Met Glu Cys Arg 50 55 60Asn Val Thr His Leu
Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly65 70 75 80Phe Gln Asp
Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met 85 90 95Ala Leu
Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys 100 105
110Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
115 120 125Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln
Val Leu 130 135 140Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser
Ser Gln Asp Ser145 150 155 160Ser Ser Ala Ala Ala Pro Gln Leu Leu
Ile Val Leu Leu Gly Leu Ser 165 170 175Ala Leu Leu Gln
180814316DNAHomo sapiens 81ctgcagctaa taaaaaaaaa aaaagaaaga
aagaaactgg tctctgtcct atttcatatg 60ctcaggtaca acttttccag agaagaagag
gaggggggcg gggaggagca ggaggaggag 120gaaagaagga ggagaaggag
aaggagaaga agaggaagag gaagaggaag aagaagaaga 180agaagaagag
gaagaggaag aggaagaaga agaagaagaa gaagaagaag aagaagaaga
240agaagaagaa gaagaagaag aagaagaaga ggaagaagag gaagaagaag
aaactgtctc 300tagaccttca ttctcaggac aagttcattg tctggcacca
agctccttgg ggtgaatttt 360cttccaaaag agtccgggga gtccaggtat
ggaatgggag gcagaaagtt caatcaaggg 420actgggattt cggaatgaat
aatgaaggga gatggactgg gtccatgccg aaggtttctc 480cctggtttct
cagcccccgg gcgaagactc agggagacat tgagacacac cctgcacagg
540agggggaggg ggagggggag ggcaaagtcc cagggcccca ggagtggctc
tcaagggctc 600aggccccgag gcggtgtctg gggttggaag gctcagtatt
gagaattccc catctcccca 660gagtttctct ttctctccca acccgtgtca
ggtccttcat cctggatact cataacgcgg 720ccccatttct cactcccatt
gggcgtcgcg tttctagaga agccaatcag tgtcgccgca 780gttcccaggt
tctaaagtcc cacgcacccc gcgggactca tatttttccc agacgcggag
840gttggggtca tggcgccccg aagcctcctc ctgctgctct caggggccct
ggccctgacc 900gatacttggg cgggtgagtg cggggtccag agagaaacgg
cctctgtggg gaggagtgag 960gggcccgccc ggtgggggcg caggactcag
ggagccgcgc ccggaggagg gtctggcggg 1020tctcaccccc tcctcgcccc
caggctccca ctccttgagg tatttcagca ccgctgtgtc 1080gcggcccggc
cgcggggagc cccgctacat cgccgtggag tacgtagacg acacgcaatt
1140cctgcggttc gacagcgacg ccgcgattcc gaggatggag ccgcgggagc
cgtgggtgga 1200gcaagagggg ccgcagtatt gggagtggac cacagggtac
gccaaggcca acgcacagac 1260tgaccgagtg gccctgagga acctgctccg
ccgctacaac cagagcgagg ctggtgagtg 1320aacccggccg ggggcgcagg
tcacgaccac cccccatccg ccacggaccg cccgggtccc 1380cccgagtctc
cggatccgaa atctaccccg aggcagcgga cccgcccaga ccctccaccc
1440gggagagtcc caggcgcctt taccgaggtt cattttcagt ttaggccaaa
atccccgcgg 1500gttgggcggg gagggggcgg ggctagctgg gcggggctga
ctgcggggac cggctagggt 1560ctcacaccct ccagggaatg aatggctgcg
acatggggcc cgacggacgc ctcctccgcg 1620ggtatcacca gcacgcgtac
gacggcaagg attacatctc cctgaacgag gacctgcgct 1680cctggaccgc
ggcggacacc gtggctcaga tcacccagcg cttctatgag gcagaggaat
1740atgcagagga gttcaggacc tacctggagg gcgagtgcct ggagttgctc
cgcagatact 1800tggagaatgg gaaggagacg ctacagcgcg caggtaccag
gggccatggg cgccttccct 1860atctcctgta gatctcttgg gatggcctcg
cacaaggttg ggaggaaagt gggcccaatg 1920ctaggatatc gccctccctc
tagtcctgag taggaagaat cttcctggct ttcgagatcc 1980ggtaccagag
agtgactgtg agagtccgcc ctgctctctg ggacaattaa gggatgaaat
2040ctctgaggga atggagggaa gacagtccct ggaataccga tccgcggtcc
cctttgagcc 2100ctccaacagc cttgggcccc gtgacttttc tctcaagttt
tgttctctgc ctcacactca 2160atgtgtttgg ggctctgatt ccagtccctc
ggcctccact taggtcaggg ccagaagtcc 2220ctgctcccca ctcagagact
cgaactttcc aaggaatagg agattttccc aggtgtctgt 2280gtccaggctg
gtgtctgggt tctgtgctcc cttccccacc ccaggtgtcc tgtccattct
2340caggttggtc acatgggtgc tgctggggtt tcccatgagg agtgcaaagt
gcctgaattt 2400tctgactctt ctcagatcct ccaaaggcac acgttgccca
ccaccccatc tctgaccatg 2460aggccaccct gaggtgctgg gccctgggct
tctaccctgc ggagatcacg ctgacctggc 2520agcgggatgg ggaggaacag
acccaggaca cagagcttgt ggagaccagg cctgcagggg 2580atggaacctt
ccagaagtgg gccgctgtgg tggtgccttc tggagaggaa cagagataca
2640catgccatgt gcagcacgag gggctgcccc agcccctcat cctgagatgg
ggtaaggagg 2700gagatgggta aagaggggaa cgaggggtca tgtcttttct
cagggaaagc aggagccctt 2760ctggagctct tcagcagggt cagggctgag
gcctggagat cagggcccct caccttccct 2820tcctttccca gagcagtctc
cccagcccac catccccatc gtgggcatcg ttgctggcct 2880tgttgtcctt
ggagctgtgg tcactggagc tgtggtcgct gctgtgatgt ggaggaagaa
2940gagctcaggt aggaaggggt gaggagtgga gtctgagttt tcttgtccca
ctgggggttg 3000caagccccaa gtagaagtgt gccctgcctc attactggga
agcaccatcc acactcatgg 3060gtctacccag cctgggccct gtgtgccagc
acctactcat ttgtaaagct cctgtgaaaa 3120tgaaggacag attcttcact
tcgatgatta tggtggtgat gggacctgat cccagcagtc 3180acaaatcaca
ggggaaggtc cctgctgatg acagacctca ggagggcagt tggtccagga
3240cccacatctg ctttcttcat atttcttgat cctgccctgg atctacagtt
acacttttct 3300ggaaacttct ctgggatcaa agactagggg tttgctctag
gaccttatgg ccctgcctcc 3360tttctggcct ctcacaggac attttcttcc
catagataga aacagaggga gctactctca 3420ggctgcaggt aagatgaagg
aggctgatcc ctgagattgt tgggatattg tggtcaggag 3480cctatgaggg
agctcaccca ccccacagtt cctctagcca catctgtggg ctctgaccag
3540gtcctgtttt tgttctaccc caatcactga cagtgcccag ggctctgggg
tgtctctcac 3600agctaataaa ggtgacactc cagggcaggg gccctgatgt
gagtggggtg ttggggggga 3660acagagggga ctcagctgtg ctattgggtt
tctttgactt ggatgtcttg agcatgaaat 3720gggctattta gagtgttacc
tctcactgtg actgatacga atttgttcat gaatattttc 3780tctatagtgt
gagacagctt ccttgtgtgg gactgagaag caagatatca atgtagcaga
3840attgcacttg tgcctcacga acatacataa attttaaaaa taaagaataa
aaatatatct 3900ttttatagat acaggtagat atgtttttat agcatgcacg
taaatgtgtg tgtgtgtgtg 3960tgtgtgtgaa gagaaagagt gaatagagag
attaagattc ttttaatggt gaaaagatat 4020acatatattt ggaattagcc
agcttgactc agtttaggtg atcccaattt tggtggcaac 4080aaccaaagca
tcgtagtcag gagccagtcg aacatatgcc ttcctctctc catcagactg
4140aatcagagtg ttgactttgg ccacatcaat gtcacaaact tcttcacagc
ctgtttgatc 4200tggtgcttgt tggctttaac atccacagtg aacacaagta
ggctgttgtt ttctatcttc 4260ttcacagcct actcagtggt cagcggaaac
ttgatgataa catggtggtc aagctt 431682362PRTHomo sapiens 82Met Ala Pro
Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 1 5 10 15Thr
Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 20 25
30Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr
35 40 45Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile
Pro 50 55 60Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro
Gln Tyr65 70 75 80Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala
Gln Thr Asp Arg 85 90 95Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn
Gln Ser Glu Ala Gly 100 105 110Ser His Thr Leu Gln Gly Met Asn Gly
Cys Asp Met Gly Pro Asp Gly 115 120 125Arg Leu Leu Arg Gly Tyr His
Gln His Ala Tyr Asp Gly Lys Asp Tyr 130 135 140Ile Ser Leu Asn Glu
Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val145 150 155 160Ala Gln
Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 165 170
175Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr
180 185 190Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro
Lys Ala 195 200 205His Val Ala His His Pro Ile Ser Asp His Glu Ala
Thr Leu Arg Cys 210 215 220Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile
Thr Leu Thr Trp Gln Arg225 230 235 240Asp Gly Glu Glu Gln Thr Gln
Asp Thr Glu Leu Val Glu Thr Arg Pro 245 250 255Ala Gly Asp Gly Thr
Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 260 265 270Gly Glu Glu
Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 275 280 285Gln
Pro Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro 290 295
300Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val
Thr305 310 315 320Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys
Ser Ser Asp Arg 325 330 335Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val
Thr Asp Ser Ala Gln Gly 340 345 350Ser Gly Val Ser Leu Thr Ala Asn
Lys Val 355 3608310DNAHomo sapiens 83tcagacgcag 108410DNAHomo
sapiens 84ttatgggatc 108510DNAHomo sapiens 85cccgcccccg
108610DNAHomo sapiens 86gaggaagaag 108710DNAHomo sapiens
87gaagctttgc 108810DNAHomo sapiens 88taccagtgta 108910DNAHomo
sapiens 89tcttctccct 109010DNAHomo sapiens 90ttggcttttc
109110DNAHomo sapiens 91ggaagggagg 109210DNAHomo sapiens
92aagccagccc 109310DNAHomo sapiens 93tttcagattg 109410DNAHomo
sapiens 94gcataggctg 109510DNAHomo sapiens 95tttgttaatt
109610DNAHomo sapiens 96gagactcctg 109710DNAHomo sapiens
97cctgtaattc 109810DNAHomo sapiens 98gtggtgcgtg 109910DNAHomo
sapiens 99ttggacctgg 1010010DNAHomo sapiens 100cttaaggatt
1010110DNAHomo sapiens 101gtctgtgaga 1010210DNAHomo sapiens
102gaaactgaac 1010310DNAHomo sapiens 103gggcatctct 1010410DNAHomo
sapiens 104tttgggccta 1010510DNAHomo sapiens 105atcgtggcgg
1010610DNAHomo sapiens 106tattatggta 1010710DNAHomo sapiens
107gcctacccga 1010810DNAHomo sapiens 108ctcgcgctgg 1010910DNAHomo
sapiens 109ttgcttgcca 1011010DNAHomo sapiens 110cctgcttgtc
1011110DNAHomo sapiens 111agggaggggc 1011210DNAHomo sapiens
112tgtgggaaat 1011310DNAHomo sapiens 113cctgatctgc 1011410DNAHomo
sapiens 114accattggat 1011510DNAHomo sapiens 115agtttgttag
1011610DNAHomo sapiens 116cctgggaagt 1011710DNAHomo sapiens
117caactaattc 1011810DNAHomo sapiens 118gcctgcagtc 1011910DNAHomo
sapiens 119cgaccccacg 1012010DNAHomo sapiens 120ttctgtgctg
1012110DNAHomo sapiens 121cgccgacgat 1012210DNAHomo sapiens
122cccgcccccg 1012310DNAHomo sapiens 123gatcaggcca 1012410DNAHomo
sapiens 124gtggaagacg 1012510DNAHomo sapiens 125gatgaggaga
1012610DNAHomo sapiens 126ttcccttctt 1012710DNAHomo sapiens
127ccccctgcag 1012810DNAHomo sapiens 128tgctgcctgt 1012910DNAHomo
sapiens 129tgcagcacga 1013010DNAHomo sapiens 130ggttattttg
1013110DNAHomo sapiens 131tgtcatcaca 1013210DNAHomo sapiens
132aaaataaaca 1013310DNAHomo sapiens 133taaaaatgtt 1013410DNAHomo
sapiens 134gagcttttga 1013510DNAHomo sapiens 135ggctgatgtg
1013610DNAHomo sapiens 136cgacgaggag 1013710DNAHomo sapiens
137gcccccaata 1013810DNAHomo sapiens 138gcaacttgga 10139408PRTHomo
sapiens 139Met Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr
Asn Arg 1 5 10 15Phe Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe
Glu Val Leu Lys 20 25 30Ala Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly
Gly Gly Val Gly Gly 35 40 45Pro Gly Ala Lys Ser Ala Ala Gln Ala Ala
Ala Gln Thr Asn Ser Asn 50 55 60Ala Ala Gly Lys Gln Leu Arg Lys Glu
Ser Gln Lys Asp Arg Lys Asn65 70 75 80Pro Leu Pro Pro Ser Val Gly
Val Val Asp Lys Lys Glu Glu Thr Gln 85 90 95Pro Pro Val Ala Leu Lys
Lys Glu Gly Ile Arg Arg Val Gly Arg Arg 100 105 110Pro Asp Gln Gln
Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro 115 120 125Glu Arg
Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu 130 135
140Lys Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp
Arg145 150 155
160Pro Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly
165 170 175Arg Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys
Arg Glu 180 185 190Phe Asp Arg His Ser Gly Ser Asp Arg Ser Ser Phe
Ser His Tyr Ser 195 200 205Gly Leu Lys His Glu Asp Lys Arg Gly Gly
Ser Gly Ser His Asn Trp 210 215 220Gly Thr Val Lys Asp Glu Leu Thr
Glu Ser Pro Lys Tyr Ile Gln Lys225 230 235 240Gln Ile Ser Tyr Asn
Tyr Ser Asp Leu Asp Gln Ser Asn Val Thr Glu 245 250 255Glu Thr Pro
Glu Gly Glu Glu His His Pro Val Ala Asp Thr Glu Asn 260 265 270Lys
Glu Asn Glu Val Glu Glu Val Lys Glu Glu Gly Pro Lys Glu Met 275 280
285Thr Leu Asp Glu Trp Lys Ala Ile Gln Asn Lys Asp Arg Ala Lys Val
290 295 300Glu Phe Asn Ile Arg Lys Pro Asn Glu Gly Ala Asp Gly Gln
Trp Lys305 310 315 320Lys Gly Phe Val Leu His Lys Ser Lys Ser Glu
Glu Ala His Ala Glu 325 330 335Asp Ser Val Met Asp His His Phe Arg
Lys Pro Ala Asn Asp Ile Thr 340 345 350Ser Gln Leu Glu Ile Asn Phe
Gly Asp Leu Gly Arg Pro Gly Arg Gly 355 360 365Gly Arg Gly Gly Arg
Gly Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg 370 375 380Gly Ser Arg
Thr Asp Lys Ser Ser Ala Ser Ala Pro Asp Val Asp Asp385 390 395
400Pro Glu Ala Phe Pro Ala Leu Ala 40514010DNAHomo sapiens
140atgataatgg 101411024DNAHomo sapiens 141ccccacccga aacacactca
gcccttgcac tgacctgcct tctgattgga ggctggttgc 60ttcggataat gacctccagg
accccactgt tggttacagc ctgtttgtat tattcttact 120gcaactcaag
acacctgcag cagggcgtga gaaaaagtaa aagaccagta ttttcacatt
180gccaggtacc agaaacacag aagactgaca cccgccactt aagtggggcc
agggctggtg 240tctgcccatg ttgccatcct gatgggctgc ttgccacaat
gagggatctt cttcaataca 300tcgcttgctt ctttgccttt ttctctgctg
ggtttttgat tgtggccacc tggactgact 360gttggatggt gaatgctgat
gactctctgg aggtgagcac aaaatgccga ggcctctggt 420gggaatgcgt
cacaaatgct tttgatggga ttcgcacctg tgatgagtac gattccatac
480ttgcggagca tcccttgaag ctggtggtaa ctcgagcgtt gatgattact
gcagatattc 540tagctgggtt tggatttctc accctgctcc ttggtcttga
ctgcgtgaaa ttcctccctg 600atgagccgta cattaaagtc cgcatctgct
ttgttgctgg agccacgtta ctaatagcag 660gtaccccagg aatcattggc
tctgtgtggt atgctgttga tgtgtatgtg gaacgttcta 720ctttggtttt
gcacaatata tttcttggta tccaatataa atttggttgg tcctgttggc
780tcggaatggc tgggtctctg ggttgctttt tggctggagc tgttctcacc
tgctgcttat 840atctttttaa agatgtggga cctgagaaaa ctagccttat
cccttgagga aagcctattc 900agccgcgagg tgtttccatg gccaagtcat
actcagcccc tcgcacagag acggccaaaa 960tgtatgctgt agacacaagg
gtgtaaaatg cacgtttcag ggtgtgtttg catatgattt 1020aatc
1024142294PRTHomo sapiens 142Pro Pro Glu Thr His Ser Ala Leu Ala
Leu Thr Cys Leu Leu Ile Gly 1 5 10 15Gly Trp Leu Leu Arg Ile Met
Thr Ser Arg Thr Pro Leu Leu Val Thr 20 25 30Ala Cys Leu Tyr Tyr Ser
Tyr Cys Asn Ser Arg His Leu Gln Gln Gly 35 40 45Val Arg Lys Ser Lys
Arg Pro Val Phe Ser His Cys Gln Val Pro Glu 50 55 60Thr Gln Lys Thr
Asp Thr Arg His Leu Ser Gly Ala Arg Ala Gly Val65 70 75 80Cys Pro
Cys Cys His Pro Asp Gly Leu Leu Ala Thr Met Arg Asp Leu 85 90 95Leu
Gln Tyr Ile Ala Cys Phe Phe Ala Phe Phe Ser Ala Gly Phe Leu 100 105
110Ile Val Ala Thr Trp Thr Asp Cys Trp Met Val Asn Ala Asp Asp Ser
115 120 125Leu Glu Val Ser Thr Lys Cys Arg Gly Leu Trp Trp Glu Cys
Val Thr 130 135 140Asn Ala Phe Asp Gly Ile Arg Thr Cys Asp Glu Tyr
Asp Ser Ile Leu145 150 155 160Ala Glu His Pro Leu Lys Leu Val Val
Thr Arg Ala Leu Met Ile Thr 165 170 175Ala Asp Ile Leu Ala Gly Phe
Gly Phe Leu Thr Leu Leu Leu Gly Leu 180 185 190Asp Cys Val Lys Phe
Leu Pro Asp Glu Pro Tyr Ile Lys Val Arg Ile 195 200 205Cys Phe Val
Ala Gly Ala Thr Leu Leu Ile Ala Gly Thr Pro Gly Ile 210 215 220Ile
Gly Ser Val Trp Tyr Ala Val Asp Val Tyr Val Glu Arg Ser Thr225 230
235 240Leu Val Leu His Asn Ile Phe Leu Gly Ile Gln Tyr Lys Phe Gly
Trp 245 250 255Ser Cys Trp Leu Gly Met Ala Gly Ser Leu Gly Cys Phe
Leu Ala Gly 260 265 270Ala Val Leu Thr Cys Cys Leu Tyr Leu Phe Lys
Asp Val Gly Pro Glu 275 280 285Lys Thr Ser Leu Ile Pro
29014310DNAHomo sapiens 143gtgggcacag 101441851DNAHomo sapiens
144ggatatcgtc gacccagcgt ccggaccggg acagctcgcg gccccccgag
agctctagcc 60gtcgaggagc tgcctgggga cgtttccctg ggccccagcc tggcccgggt
caccctggca 120tgaggagatg ggcctgttgc tcctggtccc gttgctcctg
ctgcccggct cctacggact 180gcccttctac aacggcttct actactccaa
cagcgccaac gaccagaacc taggcaacgg 240tcatggcaaa gacctcctta
atggagtgaa gctggtggtg gagacacccg aggagaccct 300gttcacctac
caaggggcca gtgtgatcct gccctgcgta ccgctacgag ccggccctgg
360tctccccgcg gcgtgtgcgt gtcaaatggt ggaagctgtc ggagaacggg
gccccagaga 420aggacgtgct ggtggccatc gggctgaggc accgctcctt
tgggactacc aaggccgcgt 480gcactgcggc aggacaaaga gcatgagctc
tcgctggaga tccagatctc gctggaggac 540tatggggctt accgctgtga
ggtcattgac gggctggagg atgaaagcgg tctggtggag 600ctggagctgc
ggggtgtggt ctttccttac cagtccccaa cgggcgctac cagttcaact
660tccacgaggg ccagcaggtc tgtgcagagc aggctgcggt ggtggcctcc
tttgagcagc 720tcttccgggc ctgggaggag ggcctggact ggtgcaacgc
gggctggctg caggatgcca 780cggtgcagta ccccatcatg ttgccccggc
agccctgcgg tggcccgggc ctggcacctg 840gcgtgcgaag ctacggcccc
cgccaccgcc gcctgcaccg ctatgatgta ttctcgttcg 900ctactgccct
caaggggcgg gtgtactacc tggagcaccc tgagaacgtg acgctgacag
960aggcaaggga ggcctgccag gaagatgatg ccacgattgc caaggtggac
agctctttgc 1020cgcctggaag ttccatggcc tggaccgctg cgacgctggc
tggctggcag atggcagcgt 1080ccgctaccct gtggttcacc cgcatcctaa
ctgtgggccc ccagagcctg gggtccgaag 1140ctttggcttc cccgacccgc
agagccgctt gtacggtgtt tactgtaccg ccagcactag 1200gacctggggc
cctcccctgc cgcattccct cactggctgt gtatttattg agtggttcgt
1260tttcccttgt gggttggagc cattttaact gtttttatac ttctcaattt
aaattttctt 1320taaacatttt tttactattt tttgtaaagc aaacagaacc
caatgcctcc ctttgctcct 1380ggatgcccca ctccaggaat catgcttgct
ccccgggctt ctggagggtt ccccgccatc 1440caggctggtc tccctccctt
aaggaggttg gtgcccagag tgggcggtgg cctgtctaga 1500atgccgccgg
gagtccgggc atggtgggca cagttctccc tgcccctcag cctgggggaa
1560gaagagggcc tcgggggctc cggagctggg ctttgggcct ctcctgccca
cctctacttc 1620tctgtgaagc cgctgacccc agtctgccca ctgaggggct
agggctggaa gccagttcta 1680ggcttccagg cgaaagctga gggaaggaag
aaactccctc cccgttcccc ttcccctctc 1740ggttccaaag aatctgtttg
ttgtcatttg tttctcctgt ttccctgtgt ggggaggggc 1800cctcaggtgt
gtgtactttg gacaataaat ggtgctatga ctgccttccg c 185114510DNAHomo
sapiens 145cctgccccgc 101464111DNAHomo sapiens 146ctcacagccc
agcacctgcg gagggagcgc tgaccatggc tccctggcct gaattgggag 60atgcccagcc
caaccccgat aagtacctcg aaggggccgc aggtcagcag cccactgccc
120ctgataaaag caaagagacc aacaaaaata acactgaggc acctgtaacc
aagattgaac 180ttctgccgtc ctactccacg gctacactga tagatgagcc
cactgaggtg gatgacccct 240ggaacctacc cactcttcag gactcgggga
tcaagtggtc agagagagac accaaaggga 300agattctctg tttcttccaa
gggattggga gattgatttt acttctcgga tttctctact 360ttttcgtgtg
ctccctggat attcttagta gcgccttcca gctggttgga ggaaaaatgg
420caggacagtt cttcagcaac agctctatta tgtccaaccc tttgttgggg
ctggtgatcg 480gggtgctggt gaccgtcttg gtgcagagct ccagcacctc
aacgtccatc gttgtcagca 540tggtgtcctc ttcattgctc actgttcggg
ctgccatccc cattatcatg ggggccaaca 600ttggaacgtc aatcaccaac
actattgttg cgctcatgca ggtgggagat cggagtgagt 660tcagaagagc
ttttgcagga gccactgtcc atgacttctt caactggctg tccctgttgg
720tgctcttgcc cgtggaggtg gccacccatt acctcgagat cataacccag
cttatagtgg 780agagcttcca cttcaagaat ggagaagatg ccccagatct
tctgaaagtc atcactaagc 840ccttcacaaa gctcattgtc cagctggata
aaaaagttat cagccaaatt gcaatgaacg 900atgaaaaagc gaaaaacaag
agtcttgtca agatttggtg caaaactttt accaacaaga 960cccagattaa
cgtcactgtt ccctcgactg ctaactgcac ctccccttcc ctctgttgga
1020cggatggcat ccaaaactgg accatgaaga atgtgaccta caaggagaac
atcgccaaat 1080gccagcatat ctttgtgaat ttccacctcc cggatcttgc
tgtgggcacc atcttgctca 1140tactctccct gctggtcctc tgtggttgcc
tgatcatgat tgtcaagatc ctgggctctg 1200tgctcaaggg gcaggtcgcc
actgtcatca agaagaccat caacactgat ttcccctttc 1260cctttgcatg
gttgactggc tacctggcca tcctcgtcgg ggcaggcatg accttcatcg
1320tacagagcag ctctgtgttc acgtcggcct tgacccccct gattggaatc
ggcgtgataa 1380ccattgagag ggcttatcca ctcacgctgg gctccaacat
cggcaccacc accaccgcca 1440tcctggccgc cttagccagc cctggcaatg
cattgaggag ttcactccag atcgccctgt 1500gccacttttt cttcaacatc
tccggcatct tgctgtggta cccgatcccg ttcactcgcc 1560tgcccatccg
catggccaag gggctgggca acatctctgc caagtatcgc tggttcgccg
1620tcttctacct gatcatcttc ttcttcctga tcccgctgac ggtgtttggc
ctctcgctgg 1680ccggctggcg ggtgctggtt ggtgtcgggg ttcccgtcgt
cttcatcatc atcctggtac 1740tgtgcctccg actcctgcag tctcgctgcc
cacgcgtcct gccgaagaaa ctccagaact 1800ggaacttcct gccgctgtgg
atgcgctcgc tgaagccctg ggatgccgtc gtctccaagt 1860tcaccggctg
cttccagatg cgctgctgct gctgctgccg cgtgtgctgc cgcgcgtgct
1920gcttgctgtg tggctgcccc aagtgctgcc gctgcagcaa gtgctgcgag
gacttggagg 1980aggcgcagga ggggcaggat gtccctgtca aggctcctga
gacctttgat aacataacca 2040ttagcagaga ggctcagggt gaggtccctg
cctcggactc aaagaccgaa tgcacggcct 2100tgtaggggac gccccagatt
gtcagggatg gggggatggt ccttgagttt tgcatgctct 2160cctccctccc
acttctgcac cctttcacca cctcgaggag atttgctccc cattagcgaa
2220tgaaattgat gcagtcctac ctaactcgat tccctttggc ttggtgggta
ggcctgcagg 2280gcacttttat tccaacccct ggtcactcag taatctttta
ctccaggaag gcacaggatg 2340gtacctaaag agaattagag aatgaacctg
gcgggacgga tgtctaatcc tgcacctagc 2400tgggttggtc agtagaacct
attttcagac tcaaaaacca tcttcagaaa gaaaaggccc 2460agggaaggaa
tgtatgagag gctctcccag atgaggaagt gtactctcta tgactatcaa
2520gctcaggcct ctcccttttt ttaaaccaaa gtctggcaac caagagcagc
agctccatgg 2580cctccttgcc ccagatcagc ctgggtcagg ggacatagtg
tcattgtttg gaaactgcag 2640accacaaggt gtgggtctat cccacttcct
agtgctcccc acattcccca tcagggcttc 2700ctcacgtgga caggtgtgct
agtccaggca gttcacttgc agtttccttg tcctcatgct 2760tcggggatgg
gagccacgcc tgaactagag ttcaggctgg atacatgtgc tcacctgctg
2820ctcttgtctt cctaagagac agagagtggg gcagatggag gagaagaaag
tgaggaatga 2880gtagcatagc attctgccaa aagggcccca gattcttaat
ttagcaaact aagaagccca 2940attcaaaagc attgtggcta aagtctaacg
ctcctctctt ggtcagataa caaaagccct 3000ccctgttgga tcttttgaaa
taaaacgtgc aagttatcca ggctcgtagc ctgcatgctg 3060ccaccttgaa
tcccagggag tatctgcacc tggaatagct ctccacccct ctctgcctcc
3120ttactttctg tgcaagatga tttcctgggt taacttcctt ctttccatcc
acccacccac 3180tggaatctct ttccaaacat ttttccattt tcccacagat
gggctttgat tagctgtcct 3240ctctccatgc ctgcaaagct ccagattttt
ggggaaagct gtacccaact ggactgccca 3300gtgaactggg atcattgagt
acagtcgagc acacgtgtgt gcatgggtca aaggggtgtg 3360ttccttctca
tcctagatgc cttctctgtg ccttccacag cctcctgcct gattacacca
3420ctgcccccgc cccaccctca gccatcccaa ttcttcctgg ccagtgcgct
ccagccttat 3480ctaggaaagg aggagtgggt gtagccgtgc agcaagattg
gggcctcccc catcccagct 3540tctccaccat cccagcaagt caggatatca
gacagtcctc ccctgaccct cccccttgta 3600gatatcaatt cccaaacaga
gccaaatact ctatatctat agtcacagcc ctgtacagca 3660tttttcataa
gttatatagt aaatggtctg catgatttgt gcttctagtg ctctcatttg
3720gaaatgaggc aggcttcttc tatgaaatgt aaagaaagaa accactttgt
atattttgta 3780ataccacctc tgtggccatg cctgccccgc ccactctgta
tatatgtaag ttaaacccgg 3840gcaggggctg tggccgtctt tgtactctgg
tgatttttaa aaattgaatc tttgtacttg 3900cattgattgt ataataattt
tgagaccagg tctcgctgtg ttgctcaggc tggtctcaaa 3960ctcctgagat
caagcaatcc gcccacctca gcctcccaaa gtgctgagat cacaggcgtg
4020agccaccacc aggcctgatt gtaatttttt tttttttttt tactggttat
gggaagggag 4080aaataaaatc atcaaacccc aaaaaaaaaa a 4111147689PRTHomo
sapiens 147Met Ala Pro Trp Pro Glu Leu Gly Asp Ala Gln Pro Asn Pro
Asp Lys 1 5 10 15Tyr Leu Glu Gly Ala Ala Gly Gln Gln Pro Thr Ala
Pro Asp Lys Ser 20 25 30Lys Glu Thr Asn Lys Asn Asn Thr Glu Ala Pro
Val Thr Lys Ile Glu 35 40 45Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu
Ile Asp Glu Pro Thr Glu 50 55 60Val Asp Asp Pro Trp Asn Leu Pro Thr
Leu Gln Asp Ser Gly Ile Lys65 70 75 80Trp Ser Glu Arg Asp Thr Lys
Gly Lys Ile Leu Cys Phe Phe Gln Gly 85 90 95Ile Gly Arg Leu Ile Leu
Leu Leu Gly Phe Leu Tyr Phe Phe Val Cys 100 105 110Ser Leu Asp Ile
Leu Ser Ser Ala Phe Gln Leu Val Gly Gly Lys Met 115 120 125Ala Gly
Gln Phe Phe Ser Asn Ser Ser Ile Met Ser Asn Pro Leu Leu 130 135
140Gly Leu Val Ile Gly Val Leu Val Thr Val Leu Val Gln Ser Ser
Ser145 150 155 160Thr Ser Thr Ser Ile Val Val Ser Met Val Ser Ser
Ser Leu Leu Thr 165 170 175Val Arg Ala Ala Ile Pro Ile Ile Met Gly
Ala Asn Ile Gly Thr Ser 180 185 190Ile Thr Asn Thr Ile Val Ala Leu
Met Gln Val Gly Asp Arg Ser Glu 195 200 205Phe Arg Arg Ala Phe Ala
Gly Ala Thr Val His Asp Phe Phe Asn Trp 210 215 220Leu Ser Leu Leu
Val Leu Leu Pro Val Glu Val Ala Thr His Tyr Leu225 230 235 240Glu
Ile Ile Thr Gln Leu Ile Val Glu Ser Phe His Phe Lys Asn Gly 245 250
255Glu Asp Ala Pro Asp Leu Leu Lys Val Ile Thr Lys Pro Phe Thr Lys
260 265 270Leu Ile Val Gln Leu Asp Lys Lys Val Ile Ser Gln Ile Ala
Met Asn 275 280 285Asp Glu Lys Ala Lys Asn Lys Ser Leu Val Lys Ile
Trp Cys Lys Thr 290 295 300Phe Thr Asn Lys Thr Gln Ile Asn Val Thr
Val Pro Ser Thr Ala Asn305 310 315 320Cys Thr Ser Pro Ser Leu Cys
Trp Thr Asp Gly Ile Gln Asn Trp Thr 325 330 335Met Lys Asn Val Thr
Tyr Lys Glu Asn Ile Ala Lys Cys Gln His Ile 340 345 350Phe Val Asn
Phe His Leu Pro Asp Leu Ala Val Gly Thr Ile Leu Leu 355 360 365Ile
Leu Ser Leu Leu Val Leu Cys Gly Cys Leu Ile Met Ile Val Lys 370 375
380Ile Leu Gly Ser Val Leu Lys Gly Gln Val Ala Thr Val Ile Lys
Lys385 390 395 400Thr Ile Asn Thr Asp Phe Pro Phe Pro Phe Ala Trp
Leu Thr Gly Tyr 405 410 415Leu Ala Ile Leu Val Gly Ala Gly Met Thr
Phe Ile Val Gln Ser Ser 420 425 430Ser Val Phe Thr Ser Ala Leu Thr
Pro Leu Ile Gly Ile Gly Val Ile 435 440 445Thr Ile Glu Arg Ala Tyr
Pro Leu Thr Leu Gly Ser Asn Ile Gly Thr 450 455 460Thr Thr Thr Ala
Ile Leu Ala Ala Leu Ala Ser Pro Gly Asn Ala Leu465 470 475 480Arg
Ser Ser Leu Gln Ile Ala Leu Cys His Phe Phe Phe Asn Ile Ser 485 490
495Gly Ile Leu Leu Trp Tyr Pro Ile Pro Phe Thr Arg Leu Pro Ile Arg
500 505 510Met Ala Lys Gly Leu Gly Asn Ile Ser Ala Lys Tyr Arg Trp
Phe Ala 515 520 525Val Phe Tyr Leu Ile Ile Phe Phe Phe Leu Ile Pro
Leu Thr Val Phe 530 535 540Gly Leu Ser Leu Ala Gly Trp Arg Val Leu
Val Gly Val Gly Val Pro545 550 555 560Val Val Phe Ile Ile Ile Leu
Val Leu Cys Leu Arg Leu Leu Gln Ser 565 570 575Arg Cys Pro Arg Val
Leu Pro Lys Lys Leu Gln Asn Trp Asn Phe Leu 580 585 590Pro Leu Trp
Met Arg Ser Leu Lys Pro Trp Asp Ala Val Val Ser Lys 595 600 605Phe
Thr Gly Cys Phe Gln Met Arg Cys Cys Cys Cys Cys Arg Val Cys 610 615
620Cys Arg Ala Cys Cys Leu Leu Cys Gly Cys Pro Lys Cys Cys Arg
Cys625 630 635 640Ser Lys Cys Cys Glu Asp Leu Glu Glu Ala Gln Glu
Gly Gln Asp Val 645 650 655Pro Val Lys Ala Pro Glu Thr Phe Asp Asn
Ile Thr Ile Ser Arg Glu 660 665 670Ala Gln Gly Glu Val Pro Ala Ser
Asp Ser Lys Thr Glu Cys Thr Ala 675 680 685Leu
uspto.report is an independent third-party trademark research tool that is not affiliated, endorsed, or sponsored by the United States Patent and Trademark Office (USPTO) or any other governmental organization. The information provided by uspto.report is based on publicly available data at the time of writing and is intended for informational purposes only.
While we strive to provide accurate and up-to-date information, we do not guarantee the accuracy, completeness, reliability, or suitability of the information displayed on this site. The use of this site is at your own risk. Any reliance you place on such information is therefore strictly at your own risk.
All official trademark data, including owner information, should be verified by visiting the official USPTO website at www.uspto.gov. This site is not intended to replace professional legal advice and should not be used as a substitute for consulting with a legal professional who is knowledgeable about trademark law.