U.S. patent application number 11/932086 was filed with the patent office on 2008-10-09 for modified anti-cd52 antibody. Invention is credited to FRANCIS J. CARR, Anita A. Hamilton.
Application Number | 20080248529 11/932086 |
Document ID | / |
Family ID | 34549504 |
Filed Date | 2008-10-09 |
United States Patent Application | 20080248529 |
Kind Code | A1 |
CARR; FRANCIS J. ; et al. | October 9, 2008 |
The present invention provides for modified forms of anti-CD52 antibodies with reduced numbers of potential T-cell epitopes that are expected to display decreased immunogenicity.
Inventors: | CARR; FRANCIS J.; (Balmedie, GB) ; Hamilton; Anita A.; (Aberdeen, GB) |
Correspondence Address: |
FULBRIGHT & JAWORSKI L.L.P. 600 CONGRESS AVE., SUITE 2400 AUSTIN TX 78701 US |
Family ID: | 34549504 |
Appl. No.: | 11/932086 |
Filed: | October 31, 2007 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
11833818 | Aug 3, 2007 | |||
11932086 | ||||
10977369 | Oct 29, 2004 | 7264806 | ||
11833818 | ||||
60516210 | Nov 1, 2003 | |||
Current U.S. Class: | 435/69.6 ; 435/320.1; 435/358 |
Current CPC Class: | A61P 1/04 20180101; A61P 9/00 20180101; C07K 16/467 20130101; A61P 43/00 20180101; A61P 25/00 20180101; A61K 2039/505 20130101; C07K 16/2893 20130101; C07K 2317/24 20130101; A61P 19/02 20180101; C07K 2319/00 20130101; A61P 37/06 20180101; A61P 35/02 20180101; A61P 27/02 20180101; A61P 29/00 20180101; A61P 17/00 20180101; C07K 2317/56 20130101; A61P 37/00 20180101 |
Class at Publication: | 435/69.6 ; 435/358; 435/320.1 |
International Class: | C12P 21/00 20060101 C12P021/00; C12N 15/64 20060101 C12N015/64; C12N 5/06 20060101 C12N005/06 |
Sequence CWU 1
1
2351121PRTRattus norvegicus 1Glu Val Lys Leu Leu Glu Ser Gly Gly
Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Met Arg Leu Ser Cys Ala Gly
Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Ile Arg Gln
Pro Ala Gly Lys Ala Pro Glu Trp Leu 35 40 45Gly Phe Ile Arg Asp Lys
Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Met65 70 75 80Leu Tyr Leu
Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Thr Tyr 85 90 95Tyr Cys
Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105
110Gln Gly Val Met Val Thr Val Ser Ser 115 1202107PRTRattus
norvegicus 2Asp Ile Lys Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser
Val Gly1 5 10 15Asp Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Asn Ile
Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ser Pro
Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Thr Gly Ile Pro
Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Val Ala Thr Tyr Phe Cys
Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys
Leu Glu Leu Lys 100 1053121PRTArtificialMutated recombinant 3Glu
Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10
15Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe
20 25 30Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr
Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala
Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Leu Val Thr Val Ser
Ser 115 1204121PRTArtificialMutated recombinant 4Glu Val Gln Leu
Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg
Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met
Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Pro Glu Trp Ile 35 40 45Gly
Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55
60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr65
70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr
Trp Gly 100 105 110Gln Gly Thr Leu Val Thr Val Ser Ser 115
1205121PRTArtificialMutated Recombinant 5Glu Val Lys Leu Gln Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Met Arg Ile Ser
Cys Ser Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp
Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu Trp Ile 35 40 45Gly Phe Ile
Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Thr65 70 75
80Leu His Leu Gln Ala Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp
Gly 100 105 110Gln Gly Thr Thr Val Thr Val Ser Ser 115
1206121PRTArtificialMUTATED RECOMBINANT 6Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser
Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45Gly Phe Ile
Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser65 70 75
80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp
Gly 100 105 110Gln Gly Thr Leu Val Thr Val Ser Ser 115
1207121PRTArtificialMutated Recombinant 7Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser
Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp
Ile Arg Gln Pro Pro Gly Lys Ala Pro Glu Trp Leu 35 40 45Gly Phe Ile
Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr65 70 75
80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp
Gly 100 105 110Gln Gly Thr Leu Val Thr Val Ser Ser 115
1208107PRTArtificialMR 8Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro Gly
Lys Ala Pro Lys Ser Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Ser
Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe
Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr
Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr
Gly Thr Lys Leu Glu Leu Lys 100 1059107PRTARTIFICIALMR 9Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg
Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu
Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40
45Tyr Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser
Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100
10510107PRTARTIFICIALMR 10Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala
Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala
Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly
Thr Gly Thr Lys Leu Glu Leu Lys 100 10511107PRTARTIFICIALMR 11Asp
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10
15Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asp Lys Tyr
20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu
Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe
Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His
Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu
Lys 100 10512107PRTARTIFICIALMR 12Asp Ile Gln Met Thr Gln Ser Pro
Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys
Lys Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln
Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn
Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp
Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr
Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100 10513121PRTARTIFICIALMR
13Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1
5 10 15Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp
Phe 20 25 30Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Pro Glu
Trp Ile 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu
Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ser Lys Asn Thr65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala
Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Leu Val Thr Val
Ser Ser 115 12014121PRTARTIFICIALMR 14Glu Val Gln Leu Gln Glu Ser
Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys
Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45Gly Phe Ile Arg
Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser65 70 75 80Leu
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90
95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly
100 105 110Gln Gly Thr Leu Val Thr Val Ser Ser 115
12015121PRTARTIFICIALMR 15Glu Val Gln Leu Gln Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala Gly Ser
Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Ile Arg Gln Pro
Pro Gly Lys Ala Pro Glu Trp Leu 35 40 45Gly Phe Ile Arg Asp Lys Ala
Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr65 70 75 80Leu Tyr Leu Gln
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala
Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln
Gly Thr Leu Val Thr Val Ser Ser 115 12016121PRTARTIFICIALMR 16Glu
Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10
15Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe
20 25 30Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Pro Glu Trp
Ile 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr
Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala
Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Leu Val Thr Val Ser
Ser 115 12017121PRTARTIFICIALMR 17Glu Val Lys Leu Gln Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Met Arg Ile Ser Cys Ser
Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Val Arg
Gln Pro Pro Gly Lys Gly Pro Glu Trp Ile 35 40 45Gly Phe Ile Arg Asp
Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Thr65 70 75 80Leu His
Leu Gln Ala Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr
Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105
110Gln Gly Thr Thr Val Thr Val Ser Ser 115 12018121PRTARTIFICIALMR
18Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1
5 10 15Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp
Phe 20 25 30Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Pro Glu
Trp Leu 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu
Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ser Lys Asn Thr65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala
Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Leu Val Thr Val
Ser Ser 115 12019121PRTARTIFICIALMR 19Glu Val Gln Leu Leu Glu Ser
Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys
Ser Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Ile
Arg Gln Pro Pro Gly Lys Ala Pro Glu Trp Ile 35 40 45Gly Phe Ile Arg
Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr65 70 75 80Leu
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90
95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly
100 105 110Gln Gly Thr Leu Val Thr Val Ser Ser 115
12020121PRTARTIFICIALMR 20Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ser Gly Ser
Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Val Arg Gln Ala
Pro Gly Lys Gly Leu Glu Trp Val 35 40 45Gly Phe Ile Arg Asp Lys Ala
Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser65 70 75 80Leu Tyr Leu Gln
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala
Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln
Gly Thr Leu Val Thr Val Ser Ser 115 12021121PRTARTIFICIALMR 21Glu
Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10
15Ser Leu Arg Leu Ser Cys Ser Gly Ser Gly Phe Thr Phe Thr Asp Phe
20 25 30Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Pro Glu Trp
Leu 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr
Asn Pro 50 55
60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr65
70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr
Trp Gly 100 105 110Gln Gly Thr Leu Val Thr Val Ser Ser 115
12022121PRTARTIFICIALMR 22Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala Gly Ser
Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Ile Arg Gln Ala
Pro Gly Lys Ala Pro Glu Trp Ile 35 40 45Gly Phe Ile Arg Asp Lys Ala
Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr65 70 75 80Leu Tyr Leu Gln
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala
Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln
Gly Thr Leu Val Thr Val Ser Ser 115 12023121PRTARTIFICIALMR 23Glu
Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10
15Ser Met Arg Ile Ser Cys Ser Gly Ser Gly Phe Thr Phe Thr Asp Phe
20 25 30Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp
Ile 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr
Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr
Gln Asn Thr65 70 75 80Leu His Leu Gln Ala Asn Thr Leu Arg Ala Glu
Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala
Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Thr Val Thr Val Ser
Ser 115 12024121PRTARTIFICIALMR 24Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala
Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Ile Arg
Gln Ala Pro Gly Lys Ala Pro Glu Trp Leu 35 40 45Gly Phe Ile Arg Asp
Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr65 70 75 80Leu Tyr
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr
Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105
110Gln Gly Thr Leu Val Thr Val Ser Ser 115 12025121PRTARTIFICIALMR
25Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1
5 10 15Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp
Phe 20 25 30Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Pro Glu
Trp Ile 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu
Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ser Lys Asn Thr65 70 75 80Leu Tyr Leu Gln Ala Asn Ser Leu Arg Ala
Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala
Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Leu Val Thr Val
Ser Ser 115 12026121PRTARTIFICIALMR 26Glu Val Gln Leu Leu Glu Ser
Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys
Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45Gly Phe Ile Arg
Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser65 70 75 80Leu
Tyr Leu Gln Ala Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90
95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly
100 105 110Gln Gly Thr Leu Val Thr Val Ser Ser 115
12027121PRTARTIFICIALMR 27Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala Gly Ser
Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Ile Arg Gln Pro
Pro Gly Lys Ala Pro Glu Trp Leu 35 40 45Gly Phe Ile Arg Asp Lys Ala
Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr65 70 75 80Leu Tyr Leu Gln
Ala Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala
Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln
Gly Thr Leu Val Thr Val Ser Ser 115 12028121PRTARTIFICIALMR 28Glu
Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10
15Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe
20 25 30Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Pro Glu Trp
Ile 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr
Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Gln Asn Thr65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala
Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Leu Val Thr Val Ser
Ser 115 12029121PRTARTIFICIALMR 29Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala
Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45Gly Phe Ile Arg Asp
Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ser65 70 75 80Leu Tyr
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr
Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105
110Gln Gly Thr Leu Val Thr Val Ser Ser 115 12030121PRTARTIFICIALMR
30Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1
5 10 15Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp
Phe 20 25 30Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Pro Glu
Trp Leu 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu
Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ser Gln Asn Thr65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala
Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Leu Val Thr Val
Ser Ser 115 12031121PRTARTIFICIALMR 31Glu Val Gln Leu Leu Glu Ser
Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys
Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Ile
Arg Gln Pro Pro Gly Lys Ala Pro Glu Trp Ile 35 40 45Gly Phe Ile Arg
Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr65 70 75 80Leu
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90
95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly
100 105 110Gln Gly Thr Leu Val Thr Val Ser Ser 115
12032121PRTARTIFICIALMR 32Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala Gly Ser
Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Val Arg Gln Ala
Pro Gly Lys Gly Leu Glu Trp Val 35 40 45Gly Phe Ile Arg Asp Lys Ala
Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe
Thr Ile Ser Arg Asp Asn Thr Lys Asn Ser65 70 75 80Leu Tyr Leu Gln
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala
Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln
Gly Thr Leu Val Thr Val Ser Ser 115 12033121PRTARTIFICIALMR 33Glu
Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10
15Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe
20 25 30Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Pro Glu Trp
Leu 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr
Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr
Lys Asn Thr65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala
Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Leu Val Thr Val Ser
Ser 115 12034121PRTARTIFICIALMR 34Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Met Arg Leu Ser Cys Ala
Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Ile Arg
Gln Pro Pro Gly Lys Ala Pro Glu Trp Leu 35 40 45Gly Phe Ile Arg Asp
Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr65 70 75 80Leu Tyr
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr
Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105
110Gln Gly Thr Leu Val Thr Val Ser Ser 115 12035121PRTARTIFICIALMR
35Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1
5 10 15Ser Met Arg Ile Ser Cys Ser Gly Ser Gly Phe Thr Phe Thr Asp
Phe 20 25 30Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu
Trp Leu 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu
Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Thr Gln Asn Thr65 70 75 80Leu His Leu Gln Ala Asn Thr Leu Arg Ala
Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala
Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Thr Val Thr Val
Ser Ser 115 12036121PRTARTIFICIALMR 36Glu Val Gln Leu Leu Glu Ser
Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys
Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 35 40 45Gly Phe Ile Arg
Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser65 70 75 80Leu
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90
95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly
100 105 110Gln Gly Thr Leu Val Thr Val Ser Ser 115
12037121PRTARTIFICIALMR 37Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala Gly Ser
Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Ile Arg Gln Pro
Pro Gly Lys Ala Pro Glu Trp Ile 35 40 45Gly Phe Ile Arg Asp Lys Ala
Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr65 70 75 80Leu Tyr Leu Gln
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala
Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln
Gly Thr Thr Val Thr Val Ser Ser 115 12038121PRTARTIFICIALMR 38Glu
Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10
15Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp Phe
20 25 30Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu Tyr
Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
Lys Asn Ser65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala Ala
Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Thr Val Thr Val Ser
Ser 115 12039121PRTARTIFICIALMR 39Glu Val Gln Leu Leu Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala
Gly Ser Gly Phe Thr Phe Thr Asp Phe 20 25 30Tyr Met Asn Trp Ile Arg
Gln Pro Pro Gly Lys Ala Pro Glu Trp Leu 35 40 45Gly Phe Ile Arg Asp
Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Asn Pro 50 55 60Ser Val Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr65 70 75 80Leu Tyr
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr
Cys Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr Trp Gly 100 105
110Gln Gly Thr Thr Val Thr Val Ser Ser 115 12040121PRTARTIFICIALMR
40Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1
5 10 15Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Thr Asp
Phe 20 25 30Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Pro Glu
Trp Leu 35 40 45Gly Phe Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr Glu
Tyr Asn Pro 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ser Lys Asn Thr65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
Glu Asp Thr Ala Thr Tyr 85 90 95Tyr Cys Ala Arg Glu Gly His Thr Ala
Ala Pro Phe Asp Tyr Trp Gly 100 105 110Gln Gly Thr Thr Val Thr Val
Ser Ser 115 12041107PRTARTIFICIALMR 41Asp Ile Gln Met Thr Gln Ser
Pro Ser Ala Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Pro Thr
Cys Arg Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45Tyr Asn Thr
Asn
Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu
Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90
95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100
10542107PRTARTIFICIALMR 42Asp Ile Gln Met Thr Gln Ser Pro Ser Ala
Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Pro Thr Cys Lys Ala
Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln
Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala
Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly
Thr Gly Thr Lys Leu Glu Leu Lys 100 10543107PRTARTIFICIALMR 43Asp
Ile Gln Met Thr Gln Ser Pro Ser Ala Leu Ser Ala Ser Val Gly1 5 10
15Asp Arg Val Thr Pro Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys Tyr
20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Ser Gly Val Pro Ser Arg Phe
Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His
Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu
Lys 100 10544107PRTARTIFICIALMR 44Asp Ile Gln Met Thr Gln Ser Pro
Ser Ala Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Pro Thr Cys
Lys Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln
Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45Tyr Asn Thr Asn Asn
Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp
Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr
Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100 10545107PRTARTIFICIALMR
45Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Leu Ser Ala Ser Val Gly1
5 10 15Asp Arg Val Thr Pro Thr Cys Lys Ala Ser Gln Asn Ile Asp Lys
Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu
Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg
Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln
His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu
Leu Lys 100 10546107PRTARTIFICIALMR 46Asp Ile Gln Met Thr Gln Ser
Pro Ser Ala Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr
Cys Arg Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45Tyr Asn Thr Asn
Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu
Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90
95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100
10547107PRTARTIFICIALMR 47Asp Ile Gln Met Thr Gln Ser Pro Ser Ala
Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Lys Ala
Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln
Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala
Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly
Thr Gly Thr Lys Leu Glu Leu Lys 100 10548107PRTARTIFICIALMR 48Asp
Ile Gln Met Thr Gln Ser Pro Ser Ala Leu Ser Ala Ser Val Gly1 5 10
15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys Tyr
20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Ser Gly Val Pro Ser Arg Phe
Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His
Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu
Lys 100 10549107PRTARTIFICIALMR 49Asp Ile Gln Met Thr Gln Ser Pro
Ser Ala Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys
Lys Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln
Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45Tyr Asn Thr Asn Asn
Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp
Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr
Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100 10550107PRTARTIFICIALMR
50Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Leu Ser Ala Ser Val Gly1
5 10 15Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asp Lys
Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu
Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg
Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln
His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu
Leu Lys 100 10551107PRTARTIFICIALMR 51Asp Ile Gln Met Thr Gln Ser
Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Pro Thr
Cys Arg Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45Tyr Asn Thr Asn
Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu
Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90
95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100
10552107PRTARTIFICIALMR 52Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Pro Thr Cys Lys Ala
Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln
Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala
Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly
Thr Gly Thr Lys Leu Glu Leu Lys 100 10553107PRTARTIFICIALMR 53Asp
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10
15Asp Arg Val Thr Pro Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys Tyr
20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Ser Gly Val Pro Ser Arg Phe
Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His
Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu
Lys 100 10554107PRTARTIFICIALMutated Recombinant 54Asp Ile Gln Met
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val
Thr Pro Thr Cys Lys Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45Tyr
Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55
60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65
70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro
Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100
10555107PRTARTIFICIALMR 55Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Pro Thr Cys Lys Ala
Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro
Gly Lys Ser Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln
Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala
Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly
Thr Gly Thr Lys Leu Glu Leu Lys 100 10556107PRTARTIFICIALMR 56Asp
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10
15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys Tyr
20 25 30Leu Asn Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Ser Leu
Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Ser Gly Val Pro Ser Arg Phe
Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His
Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu
Lys 100 10557107PRTSEQ ID 58 57Asp Ile Gln Met Thr Gln Ser Pro Ser
Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Lys
Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys
Ser Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu
Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Ile
Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr Phe
Gly Thr Gly Thr Lys Leu Glu Leu Lys 100 10558107PRTARTIFICIALMR
58Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1
5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys
Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu
Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Ser Gly Val Pro Ser Arg
Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln
His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu
Leu Lys 100 10559107PRTARTIFICIALMR 59Asp Ile Gln Met Thr Gln Ser
Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr
Cys Lys Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln
Gln Lys Ser Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45Tyr Asn Thr Asn
Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu
Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90
95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100
10560107PRTARTIFICIALMR 60Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Lys Ala
Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Ser
Gly Lys Ser Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln
Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala
Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly
Thr Gly Thr Lys Leu Glu Leu Lys 100 10561107PRTARTIFICIALMR 61Asp
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10
15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys Tyr
20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu
Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Ser Gly Met Pro Ser Arg Phe
Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His
Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu
Lys 100 10562107PRTARTIFICIALMR 62Asp Ile Gln Met Thr Gln Ser Pro
Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys
Lys Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn
Leu Gln Thr Gly Met Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp
Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr
Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100 10563107PRTARTIFICIALMR
63Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1
5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys
Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Ser Gly Met Pro Ser Arg
Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln
His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu
Leu Lys 100 10564107PRTARTIFICIALMR 64Asp Ile Gln Met Thr Gln Ser
Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr
Cys Lys Ala Ser Gln
Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
Ala Pro Lys Ser Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Thr Gly
Met Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr
Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr
Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly
Thr Lys Leu Glu Leu Lys 100 10565107PRTARTIFICIALMR 65Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg
Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu
Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 35 40
45Tyr Asn Thr Asn Asn Leu Gln Thr Gly Met Pro Ser Arg Phe Ser Gly
50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser
Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100
10566107PRTARTIFICIALMR 66Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala
Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Ser
Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln
Ser Gly Met Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala
Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly
Thr Gly Thr Lys Leu Glu Leu Lys 100 10567107PRTARTIFICIALMR 67Asp
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10
15Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asp Lys Tyr
20 25 30Leu Asn Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu Leu
Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Thr Gly Met Pro Ser Arg Phe
Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His
Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu
Lys 100 10568107PRTARTIFICIALMR 68Asp Ile Gln Met Thr Gln Ser Pro
Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys
Arg Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln
Lys Ser Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn
Leu Gln Ser Gly Met Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp
Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90 95Thr
Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100 10569107PRTARTIFICIALMR
69Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1
5 10 15Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asp Lys
Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Ser
Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Thr Gly Met Pro Ser Arg
Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
Ser Leu Gln Pro65 70 75 80Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln
His Ile Ser Arg Pro Arg 85 90 95Thr Phe Gly Thr Gly Thr Lys Leu Glu
Leu Lys 100 10570107PRTARTIFICIALMR 70Asp Ile Gln Met Thr Gln Ser
Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr
Cys Lys Ala Ser Gln Asn Ile Asp Lys Tyr 20 25 30Leu Asn Trp Tyr Gln
Gln Lys Ser Gly Lys Ser Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn
Asn Leu Gln Thr Gly Met Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu
Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Pro Arg 85 90
95Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 100
10571363DNAARTIFICIALMR 71gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactgggt ccgccaggct 120ccagggaagg gacttgagtg
ggtgggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataattc caaaaacacc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 36372363DNAARTIFICIALMR 72gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactggat tcgccagcct
120cccgggaaag cacctgagtg gattggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataattc caaaaacacc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
36373363DNAARTIFICIALMR 73gaggtgaaac tgcaggaatc tggaggaggc
ttggtacagc cggggggttc tatgagaatc 60tcctgttcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccagcct 120cccgggaaag gacctgagtg
gattggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataatac ccaaaacacc
240ctccatcttc aagctaacac cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaactaccgt caccgtctcc 360tca 36374363DNAARTIFICIALMR 74gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactgggt ccgccaggct
120ccagggaagg gacttgagtg ggtgggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataatgc caaaaactcc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
36375363DNAARTIFICIALMR 75gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccagcct 120cccgggaaag cacctgagtg
gctgggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataattc caaaaacacc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 36376321DNAARTIFICIALMR 76gacatccaga
tgacccagtc tccctcatcc ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca
gagcaagtca gaatattgac aaatacttaa actggtatca gcaaaagccc
120ggaaaagctc ccaaatccct gatatataat acaaacaatt tgcaatctgg
cgtcccatca 180aggttcagtg gcagtggatc tggtactgat ttcacactca
ccatcagcag cctgcagcct 240gaagatattg ccacatatta ctgcttgcag
catataagta ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
32177321DNAARTIFICIALMR 77gacatccaga tgacccagtc tccctcatcc
ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca aagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagccc 120ggaaaagctc ccaaactcct
gatatataat acaaacaatt tgcaaacggg cgtcccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 32178321DNAARTIFICIALMR
78gacatccaga tgacccagtc tccctcatcc ctgtctgcat ctgtgggaga cagagtcact
60atcacctgca gagcaagtca gaatattgac aaatacttaa actggtatca gcaaaagccc
120ggaaaagctc ccaaactcct gatatataat acaaacaatt tgcaatctgg
cgtcccatca 180aggttcagtg gcagtggatc tggtactgat ttcacactca
ccatcagcag cctgcagcct 240gaagatattg ccacatatta ctgcttgcag
catataagta ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
32179321DNAARTIFICIALMR 79gacatccaga tgacccagtc tccctcatcc
ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca aagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagccc 120ggaaaagctc ccaaatccct
gatatataat acaaacaatt tgcaaacggg cgtcccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 32180321DNAARTIFICIALMR
80gacatccaga tgacccagtc tccctcatcc ctgtctgcat ctgtgggaga cagagtcact
60atcacctgca aagcaagtca gaatattgac aaatacttaa actggtatca gcaaaagccc
120ggaaaatctc ccaaactcct gatatataat acaaacaatt tgcaaacggg
cgtcccatca 180aggttcagtg gcagtggatc tggtactgat ttcacactca
ccatcagcag cctgcagcct 240gaagatattg ccacatatta ctgcttgcag
catataagta ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
32181363DNAARTIFICIALMR 81gaggtgcaac tgcaggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccagcct 120cccgggaaag cacctgagtg
gattggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataattc caaaaacacc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 36382363DNAARTIFICIALMR 82gaggtgcaac
tgcaggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactgggt ccgccaggct
120ccagggaagg gacttgagtg ggtgggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataatgc caaaaactcc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
36383363DNAARTIFICIALMR 83gaggtgcaac tgcaggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccagcct 120cccgggaaag cacctgagtg
gctgggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataattc caaaaacacc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 36384363DNAARTIFICIALMR 84gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactgggt ccgccagcct
120cccgggaaag cacctgagtg gattggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataattc caaaaacacc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
36385363DNAARTIFICIALMR 85gaggtgaaac tgcaggaatc tggaggaggc
ttggtacagc cggggggttc tatgagaatc 60tcctgttcag gttctggatt caccttcact
gatttctaca tgaactgggt ccgccagcct 120cccgggaaag gacctgagtg
gattggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataatac ccaaaacacc
240ctccatcttc aagctaacac cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaactaccgt caccgtctcc 360tca 36386363DNAARTIFICIALMR 86gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactgggt ccgccagcct
120cccgggaaag cacctgagtg gctgggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataattc caaaaacacc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
36387363DNAARTIFICIALMR 87gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgttcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccagcct 120cccgggaaag cacctgagtg
gattggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataattc caaaaacacc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 36388363DNAARTIFICIALMR 88gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgttcag
gttctggatt caccttcact gatttctaca tgaactgggt ccgccaggct
120ccagggaagg gacttgagtg ggtgggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataatgc caaaaactcc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
36389363DNAARTIFICIALMR 89gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgttcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccagcct 120cccgggaaag cacctgagtg
gctgggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataattc caaaaacacc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 36390363DNAARTIFICIALMR 90gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactggat tcgccaggct
120cccgggaaag cacctgagtg gattggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataattc caaaaacacc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
36391363DNAARTIFICIALMR 91gaggtgaaac tgcaggaatc tggaggaggc
ttggtacagc cggggggttc tatgagaatc 60tcctgttcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccaggct 120cccgggaaag gacctgagtg
gattggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataatac ccaaaacacc
240ctccatcttc aagctaacac cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaactaccgt caccgtctcc 360tca 36392363DNAARTIFICIALMR 92gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactggat tcgccaggct
120cccgggaaag cacctgagtg gctgggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataattc caaaaacacc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
36393363DNAARTIFICIALMR 93gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccagcct 120cccgggaaag cacctgagtg
gattggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataattc caaaaacacc
240ctctatcttc aagctaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 36394363DNAARTIFICIALMR 94gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactgggt ccgccaggct
120ccagggaagg gacttgagtg ggtgggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataatgc caaaaactcc 240ctctatcttc aagctaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
36395363DNAARTIFICIALMR 95gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccagcct 120cccgggaaag cacctgagtg
gctgggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataattc caaaaacacc
240ctctatcttc aagctaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga
300gagggccaca ctgctgctcc ttttgattac tggggccaag gaacactggt
caccgtctcc 360tca 36396363DNAARTIFICIALMR 96gaggtgcaac tgttggaatc
tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt
caccttcact gatttctaca tgaactggat tcgccagcct 120cccgggaaag
cacctgagtg gattggtttt attagagaca aagctaaagg ttacacaaca
180gagtacaatc catctgtgaa ggggcggttc accatctcca gagataattc
ccaaaacacc 240ctctatcttc aaatgaactc cctaagagct gaggacactg
ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac
tggggccaag gaacactggt caccgtctcc 360tca 36397363DNAARTIFICIALMR
97gaggtgcaac tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc
60tcctgtgcag gttctggatt caccttcact gatttctaca tgaactgggt ccgccaggct
120ccagggaagg gacttgagtg ggtgggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataatgc ccaaaactcc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
36398363DNAARTIFICIALMR 98gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccagcct 120cccgggaaag cacctgagtg
gctgggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataattc ccaaaacacc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 36399363DNAARTIFICIALMR 99gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactggat tcgccagcct
120cccgggaaag cacctgagtg gattggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataatac caaaaacacc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
363100363DNAARTIFICIALMR 100gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactgggt ccgccaggct 120ccagggaagg gacttgagtg
ggtgggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataatac caaaaactcc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 363101363DNAARTIFICIALMR 101gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactggat tcgccagcct
120cccgggaaag cacctgagtg gctgggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataatac caaaaacacc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacactggt caccgtctcc 360tca
363102363DNAARTIFICIALMR 102gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tatgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccagcct 120cccgggaaag cacctgagtg
gctgggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataattc caaaaacacc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 363103363DNAARTIFICIALMR 103gaggtgaaac
tgcaggaatc tggaggaggc ttggtacagc cggggggttc tatgagaatc 60tcctgttcag
gttctggatt caccttcact gatttctaca tgaactggat tcgccagcct
120cccgggaaag gacctgagtg gctgggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataatac ccaaaacacc 240ctccatcttc aagctaacac cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaactaccgt caccgtctcc 360tca
363104363DNAARTIFICIALMR 104gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactgggt ccgccaggct 120ccagggaagg gacttgagtg
gctgggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataatgc caaaaactcc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 363105363DNAARTIFICIALMR 105gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactggat tcgccagcct
120cccgggaaag cacctgagtg gattggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataattc caaaaacacc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacaaccgt caccgtctcc 360tca
363106363DNAARTIFICIALMR 106gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactgggt ccgccaggct 120ccagggaagg gacttgagtg
ggtgggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataatgc caaaaactcc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccgtttacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacaaccgt caccgtctcc 360tca 363107363DNAARTIFICIALMR 107gaggtgcaac
tgttggaatc tggaggaggc ttggtacagc cggggggttc tctgagactc 60tcctgtgcag
gttctggatt caccttcact gatttctaca tgaactggat tcgccagcct
120cccgggaaag cacctgagtg gctgggtttt attagagaca aagctaaagg
ttacacaaca 180gagtacaatc catctgtgaa ggggcggttc accatctcca
gagataattc caaaaacacc 240ctctatcttc aaatgaactc cctaagagct
gaggacactg ccgtttacta ctgtgcaaga 300gagggccaca ctgctgctcc
ttttgattac tggggccaag gaacaaccgt caccgtctcc 360tca
363108363DNAARTIFICIALMR 108gaggtgcaac tgttggaatc tggaggaggc
ttggtacagc cggggggttc tctgagactc 60tcctgtgcag gttctggatt caccttcact
gatttctaca tgaactggat tcgccagcct 120cccgggaaag cacctgagtg
gctgggtttt attagagaca aagctaaagg ttacacaaca 180gagtacaatc
catctgtgaa ggggcggttc accatctcca gagataattc caaaaacacc
240ctctatcttc aaatgaactc cctaagagct gaggacactg ccacctacta
ctgtgcaaga 300gagggccaca ctgctgctcc ttttgattac tggggccaag
gaacactggt caccgtctcc 360tca 363109321DNAARTIFICIALMR 109gacatccaga
tgacccagtc tccctcagcc ctgtctgcat ctgtgggaga cagagtcact 60cccacctgca
gagcaagtca gaatattgac aaatacttaa actggtatca gcaaaagccc
120ggaaaagctc ccaaatccct gatatataat acaaacaatt tgcaatctgg
cgtcccatca 180aggttcagtg gcagtggatc tggtactgat ttcacactca
ccatcagcag cctgcagcct 240gaagatattg ccacatatta ctgcttgcag
catataagta ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
321110321DNAARTIFICIALMR 110gacatccaga tgacccagtc tccctcagcc
ctgtctgcat ctgtgggaga cagagtcact 60cccacctgca aagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagccc 120ggaaaagctc ccaaactcct
gatatataat acaaacaatt tgcaaacggg cgtcccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 321111321DNAARTIFICIALMR
111gacatccaga tgacccagtc tccctcagcc ctgtctgcat ctgtgggaga
cagagtcact 60cccacctgca gagcaagtca gaatattgac aaatacttaa actggtatca
gcaaaagccc 120ggaaaagctc ccaaactcct gatatataat acaaacaatt
tgcaatctgg cgtcccatca 180aggttcagtg gcagtggatc tggtactgat
ttcacactca ccatcagcag cctgcagcct 240gaagatattg ccacatatta
ctgcttgcag catataagta ggccgcgcac gtttggaact 300gggaccaagc
tggagctgaa a 321112321DNAARTIFICIALMR 112gacatccaga tgacccagtc
tccctcagcc ctgtctgcat ctgtgggaga cagagtcact 60cccacctgca aagcaagtca
gaatattgac aaatacttaa actggtatca gcaaaagccc 120ggaaaagctc
ccaaatccct gatatataat acaaacaatt tgcaaacggg cgtcccatca
180aggttcagtg gcagtggatc tggtactgat ttcacactca ccatcagcag
cctgcagcct 240gaagatattg ccacatatta ctgcttgcag catataagta
ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
321113321DNAARTIFICIALMR 113gacatccaga tgacccagtc tccctcagcc
ctgtctgcat ctgtgggaga cagagtcact 60cccacctgca aagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagccc 120ggaaaatctc ccaaactcct
gatatataat acaaacaatt tgcaaacggg cgtcccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 321114321DNAARTIFICIALMR
114gacatccaga tgacccagtc tccctcagcc ctgtctgcat ctgtgggaga
cagagtcact 60atcacctgca gagcaagtca gaatattgac aaatacttaa actggtatca
gcaaaagccc 120ggaaaagctc ccaaatccct gatatataat acaaacaatt
tgcaatctgg cgtcccatca 180aggttcagtg gcagtggatc tggtactgat
ttcacactca ccatcagcag cctgcagcct 240gaagatattg ccacatatta
ctgcttgcag catataagta ggccgcgcac gtttggaact 300gggaccaagc
tggagctgaa a 321115321DNAARTIFICIALMR 115gacatccaga tgacccagtc
tccctcagcc ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca aagcaagtca
gaatattgac aaatacttaa actggtatca gcaaaagccc 120ggaaaagctc
ccaaactcct gatatataat acaaacaatt tgcaaacggg cgtcccatca
180aggttcagtg gcagtggatc tggtactgat ttcacactca ccatcagcag
cctgcagcct 240gaagatattg ccacatatta ctgcttgcag catataagta
ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
321116321DNAARTIFICIALMR 116gacatccaga tgacccagtc tccctcagcc
ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca gagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagccc 120ggaaaagctc ccaaactcct
gatatataat acaaacaatt tgcaatctgg cgtcccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 321117321DNAARTIFICIALMR
117gacatccaga tgacccagtc tccctcagcc ctgtctgcat ctgtgggaga
cagagtcact 60atcacctgca aagcaagtca gaatattgac aaatacttaa actggtatca
gcaaaagccc 120ggaaaagctc ccaaatccct gatatataat acaaacaatt
tgcaaacggg cgtcccatca 180aggttcagtg gcagtggatc tggtactgat
ttcacactca ccatcagcag cctgcagcct 240gaagatattg ccacatatta
ctgcttgcag catataagta ggccgcgcac gtttggaact 300gggaccaagc
tggagctgaa a 321118321DNAARTIFICIALMR 118gacatccaga tgacccagtc
tccctcagcc ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca aagcaagtca
gaatattgac aaatacttaa actggtatca gcaaaagccc 120ggaaaatctc
ccaaactcct gatatataat acaaacaatt tgcaaacggg cgtcccatca
180aggttcagtg gcagtggatc tggtactgat ttcacactca ccatcagcag
cctgcagcct 240gaagatattg ccacatatta ctgcttgcag catataagta
ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
321119321DNAARTIFICIALMR 119gacatccaga tgacccagtc tccctcatcc
ctgtctgcat ctgtgggaga cagagtcact 60cccacctgca gagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagccc 120ggaaaagctc ccaaatccct
gatatataat acaaacaatt tgcaatctgg cgtcccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 321120321DNAARTIFICIALMR
120gacatccaga tgacccagtc tccctcatcc ctgtctgcat ctgtgggaga
cagagtcact 60cccacctgca aagcaagtca gaatattgac aaatacttaa actggtatca
gcaaaagccc 120ggaaaagctc ccaaactcct gatatataat acaaacaatt
tgcaaacggg cgtcccatca 180aggttcagtg gcagtggatc tggtactgat
ttcacactca ccatcagcag cctgcagcct 240gaagatattg ccacatatta
ctgcttgcag catataagta ggccgcgcac gtttggaact 300gggaccaagc
tggagctgaa a 321121321DNAARTIFICIALMR 121gacatccaga tgacccagtc
tccctcatcc ctgtctgcat ctgtgggaga cagagtcact 60cccacctgca gagcaagtca
gaatattgac aaatacttaa actggtatca gcaaaagccc 120ggaaaagctc
ccaaactcct gatatataat acaaacaatt tgcaatctgg cgtcccatca
180aggttcagtg gcagtggatc tggtactgat ttcacactca ccatcagcag
cctgcagcct 240gaagatattg ccacatatta ctgcttgcag catataagta
ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
321122321DNAARTIFICIALMR 122gacatccaga tgacccagtc tccctcatcc
ctgtctgcat ctgtgggaga cagagtcact 60cccacctgca aagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagccc 120ggaaaagctc ccaaatccct
gatatataat acaaacaatt tgcaaacggg cgtcccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 321123321DNAARTIFICIALMR
123gacatccaga tgacccagtc tccctcatcc ctgtctgcat ctgtgggaga
cagagtcact 60cccacctgca aagcaagtca gaatattgac aaatacttaa actggtatca
gcaaaagccc 120ggaaaatctc ccaaactcct gatatataat acaaacaatt
tgcaaacggg cgtcccatca 180aggttcagtg gcagtggatc tggtactgat
ttcacactca ccatcagcag cctgcagcct 240gaagatattg ccacatatta
ctgcttgcag catataagta ggccgcgcac gtttggaact 300gggaccaagc
tggagctgaa a 321124321DNAARTIFICIALMR 124gacatccaga tgacccagtc
tccctcatcc ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca gagcaagtca
gaatattgac aaatacttaa actggtatca gcaaaagtct 120ggaaaagctc
ccaaatccct gatatataat acaaacaatt tgcaatctgg cgtcccatca
180aggttcagtg gcagtggatc tggtactgat ttcacactca ccatcagcag
cctgcagcct 240gaagatattg ccacatatta ctgcttgcag catataagta
ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
321125321DNAARTIFICIALMR 125gacatccaga tgacccagtc tccctcatcc
ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca aagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagtct 120ggaaaagctc ccaaactcct
gatatataat acaaacaatt tgcaaacggg cgtcccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 321126321DNAARTIFICIALMR
126gacatccaga tgacccagtc tccctcatcc ctgtctgcat ctgtgggaga
cagagtcact 60atcacctgca gagcaagtca gaatattgac aaatacttaa actggtatca
gcaaaagtct 120ggaaaagctc ccaaactcct gatatataat acaaacaatt
tgcaatctgg cgtcccatca 180aggttcagtg gcagtggatc tggtactgat
ttcacactca ccatcagcag cctgcagcct 240gaagatattg ccacatatta
ctgcttgcag catataagta ggccgcgcac gtttggaact 300gggaccaagc
tggagctgaa a 321127321DNAARTIFICIALMR 127gacatccaga tgacccagtc
tccctcatcc ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca aagcaagtca
gaatattgac aaatacttaa actggtatca gcaaaagtct 120ggaaaagctc
ccaaatccct gatatataat acaaacaatt tgcaaacggg cgtcccatca
180aggttcagtg gcagtggatc tggtactgat ttcacactca ccatcagcag
cctgcagcct 240gaagatattg ccacatatta ctgcttgcag catataagta
ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
321128321DNAARTIFICIALMR 128gacatccaga tgacccagtc tccctcatcc
ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca aagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagtct 120ggaaaatctc ccaaactcct
gatatataat acaaacaatt tgcaaacggg cgtcccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 321129321DNAARTIFICIALMR
129gacatccaga tgacccagtc tccctcatcc ctgtctgcat ctgtgggaga
cagagtcact 60atcacctgca gagcaagtca gaatattgac aaatacttaa actggtatca
gcaaaagccc 120ggaaaagctc ccaaatccct gatatataat acaaacaatt
tgcaatctgg catgccatca 180aggttcagtg gcagtggatc tggtactgat
ttcacactca ccatcagcag cctgcagcct 240gaagatattg ccacatatta
ctgcttgcag catataagta ggccgcgcac gtttggaact 300gggaccaagc
tggagctgaa a 321130321DNAARTIFICIALMR 130gacatccaga tgacccagtc
tccctcatcc ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca aagcaagtca
gaatattgac aaatacttaa actggtatca gcaaaagccc 120ggaaaagctc
ccaaactcct gatatataat acaaacaatt tgcaaacggg catgccatca
180aggttcagtg gcagtggatc tggtactgat ttcacactca ccatcagcag
cctgcagcct 240gaagatattg ccacatatta ctgcttgcag catataagta
ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
321131321DNAARTIFICIALMR 131gacatccaga tgacccagtc tccctcatcc
ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca gagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagccc 120ggaaaagctc ccaaactcct
gatatataat acaaacaatt tgcaatctgg catgccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 321132321DNAARTIFICIALMR
132gacatccaga tgacccagtc tccctcatcc ctgtctgcat ctgtgggaga
cagagtcact 60atcacctgca aagcaagtca gaatattgac aaatacttaa actggtatca
gcaaaagccc 120ggaaaagctc ccaaatccct gatatataat acaaacaatt
tgcaaacggg catgccatca 180aggttcagtg gcagtggatc tggtactgat
ttcacactca ccatcagcag cctgcagcct 240gaagatattg ccacatatta
ctgcttgcag catataagta ggccgcgcac gtttggaact 300gggaccaagc
tggagctgaa a 321133321DNAARTIFICIALMR 133gacatccaga tgacccagtc
tccctcatcc ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca
aagcaagtca
gaatattgac aaatacttaa actggtatca gcaaaagccc 120ggaaaatctc
ccaaactcct gatatataat acaaacaatt tgcaaacggg catgccatca
180aggttcagtg gcagtggatc tggtactgat ttcacactca ccatcagcag
cctgcagcct 240gaagatattg ccacatatta ctgcttgcag catataagta
ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
321134321DNAARTIFICIALMR 134gacatccaga tgacccagtc tccctcatcc
ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca gagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagtct 120ggaaaagctc ccaaatccct
gatatataat acaaacaatt tgcaatctgg catgccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 321135321DNAARTIFICIALMR
135gacatccaga tgacccagtc tccctcatcc ctgtctgcat ctgtgggaga
cagagtcact 60atcacctgca aagcaagtca gaatattgac aaatacttaa actggtatca
gcaaaagtct 120ggaaaagctc ccaaactcct gatatataat acaaacaatt
tgcaaacggg catgccatca 180aggttcagtg gcagtggatc tggtactgat
ttcacactca ccatcagcag cctgcagcct 240gaagatattg ccacatatta
ctgcttgcag catataagta ggccgcgcac gtttggaact 300gggaccaagc
tggagctgaa a 321136321DNAARTIFICIALMR 136gacatccaga tgacccagtc
tccctcatcc ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca gagcaagtca
gaatattgac aaatacttaa actggtatca gcaaaagtct 120ggaaaagctc
ccaaactcct gatatataat acaaacaatt tgcaatctgg catgccatca
180aggttcagtg gcagtggatc tggtactgat ttcacactca ccatcagcag
cctgcagcct 240gaagatattg ccacatatta ctgcttgcag catataagta
ggccgcgcac gtttggaact 300gggaccaagc tggagctgaa a
321137321DNAARTIFICIALMR 137gacatccaga tgacccagtc tccctcatcc
ctgtctgcat ctgtgggaga cagagtcact 60atcacctgca aagcaagtca gaatattgac
aaatacttaa actggtatca gcaaaagtct 120ggaaaagctc ccaaatccct
gatatataat acaaacaatt tgcaaacggg catgccatca 180aggttcagtg
gcagtggatc tggtactgat ttcacactca ccatcagcag cctgcagcct
240gaagatattg ccacatatta ctgcttgcag catataagta ggccgcgcac
gtttggaact 300gggaccaagc tggagctgaa a 321138321DNAARTIFICIALMR
138gacatccaga tgacccagtc tccctcatcc ctgtctgcat ctgtgggaga
cagagtcact 60atcacctgca aagcaagtca gaatattgac aaatacttaa actggtatca
gcaaaagtct 120ggaaaatctc ccaaactcct gatatataat acaaacaatt
tgcaaacggg catgccatca 180aggttcagtg gcagtggatc tggtactgat
ttcacactca ccatcagcag cctgcagcct 240gaagatattg ccacatatta
ctgcttgcag catataagta ggccgcgcac gtttggaact 300gggaccaagc
tggagctgaa a 321139330PRTHomo Sapiens 139Ala Ser Thr Lys Gly Pro
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys1 5 10 15Ser Thr Ser Gly Gly
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30Phe Pro Glu Pro
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60Leu Ser
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr65 70 75
80Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys 100 105 110Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro 115 120 125Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys 130 135 140Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp145 150 155 160Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200
205Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Asp Glu225 230 235 240Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr 245 250 255Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn 260 265 270Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285Leu Tyr Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr305 310 315
320Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330140106PRTHomo
Sapiens 140Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
Glu Gln1 5 10 15Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn
Asn Phe Tyr 20 25 30Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
Ala Leu Gln Ser 35 40 45Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp
Ser Lys Asp Ser Thr 50 55 60Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser
Lys Ala Asp Tyr Glu Lys65 70 75 80His Lys Leu Tyr Ala Cys Glu Val
Thr His Gln Gly Leu Ser Ser Pro 85 90 95Val Thr Lys Ser Phe Asn Arg
Gly Glu Cys 100 10514120DNAARTIFICIALSYNTHESIZED 141tccacaggtg
tccactccga 2014241DNAARTIFICIALSYNTHESIZED 142ccagattcca acagtttcac
ctcggagtgg acacctgtgg a 4114339DNAARTIFICIALSYNTHESIZED
143ggtgaaactg ttggaatctg gaggaggctt ggtacagcc
3914440DNAARTIFICIALSYNTHESIZED 144ggagagtctc atagaacccc ccggctgtac
caagcctcct 4014541DNAARTIFICIALSYNTHESIED 145ggggggttct atgagactct
cctgtgcagg ttctggattc a 4114639DNAARTIFICIALSYNTHESIZED
146catgtagaaa tcagtgaagg tgaatccaga acctgcaca
3914740DNAARTIFICIALSYNTHESIZED 147ccttcactga tttctacatg aactggattc
gccagcctgc 4014840DNAARTIFICIALSYNTHESIZED 148gccactcagg tgccttccct
gcaggctggc gaatccagtt 4014940DNAARTIFICIALSYNTHESIZED 149agggaaggca
cctgagtggc tgggttttat tagagacaaa 4015040DNAARTIFICIALSYNTHESIZED
150tctgttgtgt aacctttagc tttgtctcta ataaaaccca
4015142DNAARTIFICIALSYNTHESIZED 151gctaaaggtt acacaacaga gtacaatcca
tctgtgaagg gg 4215240DNAARTIFICIALSYNTHESIZED 152tctggagatg
gtgaaccgcc ccttcacaga tggattgtac 4015338DNAARTIFICIALSYNTHESIZED
153cggttcacca tctccagaga taatacccaa aacatgct
3815440DNAARTIFICIALSYNTHESIZED 154gggtgttcat ttgaagatag agcatgtttt
gggtattatc 4015540DNAARTIFICIALSYNTHESIZED 155ctatcttcaa atgaacaccc
taagagctga ggacactgcc 4015640DNAARTIFICIALSYNTHESIZED 156tctcttgcac
agtagtaagt ggcagtgtcc tcagctctta 4015742DNAARTIFICIALSYNTHESIZED
157acttactact gtgcaagaga gggccacact gctgctcctt tt
4215841DNAARTIFICIALSYNTHESIZED 158ctccttggcc ccagtaatca aaaggagcag
cagtgtggcc c 4115939DNAARTIFICIALSYNTHESIZED 159gattactggg
gccaaggagt catggtcacc gtctcctca 3916020DNAARTIFICIALSYNTHESIZED
160tgaggagacg gtgaccatga 2016138DNAARTIFICIALSYNTHESIZED
161gcatgttgac cctgacgcaa gcttgccgcc accatggg
3816227DNAARTIFICIALSYNTHESIZED 162ggagtggaca cctgtggaga gaaaggc
2716336DNAARTIFICIALSYNTHESIZED 163gcgatagctg gactgaatgg atcctataaa
tctctg 3616421DNAARTIFICIALSYNTHESIZED 164tccacaggtg tccactccga c
2116539DNAARTIFICIALSYNTHESIZED 165agactgggtc atcttgatgt cggagtggac
acctgtgga 3916640DNAARTIFICIALSYNTHESIZED 166atcaagatga cccagtctcc
ctcattcctg tctgcatctg 4016741DNAARTIFICIALSYNTHESIZED 167agagtgactc
tgtctcccac agatgcagac aggaatgagg g 4116840DNAARTIFICIALSYNTHESIZED
168tgggagacag agtcactctc aactgcaaag caagtcagaa
4016940DNAARTIFICIALSYNTHESIZED 169gtttaagtat ttgtcaatat tctgacttgc
tttgcagttg 4017040DNAARTIFICIALSYNTHESIZED 170tattgacaaa tacttaaact
ggtatcagca aaagctggga 4017140DNAARTIFICIALSYNTHESIZED 171tcaggagttt
gggagattct cccagctttt gctgatacca 4017240DNAARTIFICIALSYNTHESIZED
172gaatctccca aactcctgat atataataca aacaatttgc
4017341DNAARTIFICIALSYNTHESIZED 173ccttgatggg atgcccgttt gcaaattgtt
tgtattatat a 4117440DNAARTIFICIALSYNTHESIZED 174aaacgggcat
cccatcaagg ttcagtggca gtggatctgg 4017539DNAARTIFICIALSYNTHESIZED
175ggtgagtgtg aaatcagtac cagatccact gccactgaa
3917640DNAARTIFICIALSYNTHESIZED 176tactgatttc acactcacca tcagcagcct
gcagcctgaa 4017741DNAARTIFICIALSYNTHESIZED 177cagaaatatg tggcaacatc
ttcaggctgc aggctgctga t 4117839DNAARTIFICIALSYNTHESIZED
178gatgttgcca catatttctg cttgcagcat ataagtagg
3917940DNAARTIFICIALSYNTHESIZED 179cccagttcca aacgtgcgcg gcctacttat
atgctgcaag 4018040DNAARTIFICIALSYNTHESIZED 180ccgcgcacgt ttggaactgg
gaccaagctg gagctgaaac 4018139DNAARTIFICIALSYNTHESIZED 181aaagtttaaa
ttctactcac gtttcagctc cagcttggt 3918238DNAARTIFICIALSYNTHESIZED
182gtgagtagaa tttaaacttt gcttcgtcga ctggatcc
3818318DNAARTIFICIALSYNTHESIZED 183ggatccagtc gacgaagc
1818438DNAARTIFICIALSYNTHESIZED 184gcatgttgac cctgacgcaa gcttgccgcc
accatggg 3818527DNAARTIFICIALSYNTHESIZED 185ggagtggaca cctgtggaga
gaaaggc 2718636DNAARTIFICIALSYNTHESIZED 186gcgatagctg gactgaatgg
atccagtcga cgaagc 3618738DNAARTIFICIALSYNTHESIZED 187gcatgttgac
cctgacgcaa gcttgccgcc accatggg 3818830DNAARTIFICIALSYNTHESIZED
188ccactccgag gtgcaactgt tggaatctgg 3018930DNAARTIFICIALSYNTHESIZED
189ccagattcca acagttgcac ctcggagtgg 3019030DNAARTIFICIALSYNTHESIZED
190agccgggggg ttctctgaga ctctcctgtg 3019130DNAARTIFICIALSYNTHESIZED
191cacaggagag tctcagagaa ccccccggct 3019235DNAARTIFICIALSYNTHESIZED
192agggaaggga cttgagtggg tgggttttat tagag
3519335DNAARTIFICIALSYNTHESIZED 193cgggaaagca cctgagtgga ttggttttat
tagag 3519443DNAARTIFICIALSYNTHESIZED 194ccactcaagt cccttccctg
gagcctggcg gacccagttc atg 4319535DNAARTIFICIALSYNTHESIZED
195ccactcaggt gctttcccgg gaggctggcg aatcc
3519648DNAARTIFICIALSYNTHESIZED 196tcttcaaatg aactccctaa gagctgagga
cactgccgtt tactactg 4819746DNAARTIFICIALSYNTHESIZED 197agggagttca
tttgaagata gagggtgttt ttggaattat ctctgg
4619835DNAARTIFICIALSYNTHESIZED 198tggggccaag gaacactggt caccgtctcc
tcagg 3519931DNAARTIFICIALSYNTHESIZED 199ggagactgtg accagtgttc
cttggcccca g 3120033DNAARTIFICIALSYNTHESIZED 200tccgaggtga
aactgcagga atctggagga ggc 3320130DNAARTIFICIALSYNTHESIZED
201ccagattcct gcagtttcac ctcggagtgg 3020235DNAARTIFICIALSYNTHESIZED
202gggggttcta tgagaatctc ctgttcaggt tctgg
3520335DNAARTIFICIALSYNTHESIZED 203gaacctgaac aggagattct catagaaccc
cccgg 3520435DNAARTIFICIALSYNTHESIZED 204cgggaaagga cctgagtgga
ttggttttat tagag 3520535DNAARTIFICIALSYNTHESIZED 205ccaatccact
caggtccttt cccgggaggc tggcg 3520641DNAARTIFICIALSYNTHESIZED
206gctaacaccc taagagctga ggacactgcc gtttactact g
4120739DNAARTIFICIALSYNTHESIZED 207ctcttagggt gttagcttga agatggaggg
tgttttggg 3920835DNAARTIFICIALSYNTHESIZED 208tggggccaag gaactaccgt
caccgtctcc tcagg 3520931DNAARTIFICIALSYNTHESIZED 209ggagacggtg
acggtagttc cttggcccca g 3121036DNAARTIFICIALSYNTHESIZED
210gataatgcca aaaactccct ctatcttcaa atgaac
3621135DNAARTIFICIALSYNTHESIZED 211atagagggag tttttggcat tatctctgga
gatgg 3521235DNAARTIFICIALSYNTHESIZED 212cgggaaagca cctgagtggc
tgggttttat tagag 3521336DNAARTIFICIALSYNTHESIZED 213gcgatagctg
gactgaatgg atcctataaa tctctg 3621438DNAARTIFICIALSYNTHESIZED
214gcatgttgac cctgacgcaa gcttgccgcc accatggg
3821532DNAARTIFICIALSYNTHESIZED 215atgacccagt ctccctcatc cctgtctgca
tc 3221635DNAARTIFICIALSYNTHESIZED 216gagggagact gggtcatctg
gatgtcggag tggac 3521734DNAARTIFICIALSYNTHESIZED 217cagagtcact
atcacctgca aagcaagtca gaat 3421834DNAARTIFICIALSYNTHESIZED
218cagagtcact atcacctgca gagcaagtca gaat
3421935DNAARTIFICIALSYNTHESIZED 219attctgactt gctttgcagg tgatagtgac
tctgt 3522035DNAARTIFICIALSYNTHESIZED 220attctgactt gctctgcagg
tgatagtgac tctgt 3522135DNAARTIFICIALSYNTHESIZED 221cccggaaaag
ctcccaaact cctgatatat aatac 3522235DNAARTIFICIALSYNTHESIZED
222cccggaaaat ctcccaaact cctgatatat aatac
3522335DNAARTIFICIALSYNTHESIZED 223cccggaaaag ctcccaaatc cctgatatat
aatac 3522432DNAARTIFICIALSYNTHESIZED 224tttgggagct tttccgggct
tttgctgata cc 3222532DNAARTIFICIALSYNTHESIZED 225tttgggagat
tttccgggct tttgctgata cc 3222627DNAARTIFICIALSYNTHESIZED
226cgtcccatca aggttcagtg gcagtgg 2722731DNAARTIFICIALSYNTHESIZED
227gccactgaac cttgatggga cgcccgtttg c
3122835DNAARTIFICIALSYNTHESIZED 228cactgaacct tgatgggacg ccagattgca
aattg 3522935DNAARTIFICIALSYNTHESIZED 229gcctgaagat attgccacat
attactgctt gcagc 3523035DNAARTIFICIALSYNTHESIZED 230tgcaagcagt
aatatgtggc aatatcttca ggctg 3523136DNAARTIFICIALSYNTHESIZED
231gcgatagctg gactgaatgg atccagtcga cgaagc 362321375DNAHomo sapiens
232cctagggttc gatcgaaaga ccccgtccgg tccggactgg aaccgaaacc
ccgtccctcc 60cccgattcca ctccgtccac cgcggtcgtc cacgtgtggg ttacgggtac
tcgggtctgt 120gacctgcgac ttggagcgcc tgtcaattct tgggtccccg
gagacgcgga cccgggtcga 180gacagggtgt ggcgccagtg taccgtggtg
gagagaacgt cggaggtggt tcccgggtag 240ccagaagggg gaccgtggga
ggaggttctc gtggagaccc ccgtgtcgcc gggacccgac 300ggaccagttc
ctgatgaagg ggcttggcca ctgccacagc accttgagtc cgcgggactg
360gtcgccgcac gtgtggaagg gccgacagga tgtcaggagt cctgagatga
gggagtcgtc 420gcaccactgg cacgggaggt cgtcgaaccc gtgggtctgg
atgtagacgt caagtgttcg 480ggtcggtgtc cacctgcttt caaccatccg
gtcgtgtccc cacagacgac cttcgtccga 540gtcgcgagga cggacctgcg
tagggccgat acgtcggggt caggtcccgt cgttccgtcc 600ggggcagacg
gagaagtggg cctcggagac gggcggggtg agtacgagtc cctctcccag
660aagaccgaaa aagggtccga gacccgtccg tgtccgatcc acggggattg
ggtccgggac 720gtgtgtttcc ccgtccacga cccgagtctg gacggttctc
ggtataggcc ctcctgggac 780ggggactgga tgttgtcgtg catggcccac
cagtcgcagg agtggcagga cgtggtcctg 840accgacttac cgttcctcat
gttcacgttc cagaggttgt ttcgggaggc ttcgggggta 900gctcttttgg
tagaggtttc ggtttccacc ctgggcaccc cacgctcccg gtgtacctgt
960ctccggccga gccgggtggg agacgggact ctcactggcg acatggttgg
agacaggatg 1020tcccgtcggg gctcttggtg tccacatgtg ggacgggggt
agggccctac tcgactggtt 1080cttggtccag tcggactgga cggaccagtt
tccgaagata gggtcgctgt agcggcacct 1140caccctctcg ttacccgtcg
gcctcttgtt gatgttctgg tgcggagggc acgacctgag 1200gctgccgagg
aagaaggaga tgtcgttcga gtggcacctg ttctcgtcca ccgtcgtccc
1260cttgcagaag agtacgaggc actacgtact ccgagacgtg ttggtgatgt
gcgtcttctc 1320ggagagggac agaggcccat ttactcacgc tgccggccca
tggctcgagc ttaag 1375233330PRTHomo sapiens 233Ala Ser Thr Lys Gly
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30Phe Pro
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45Gly
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55
60Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val
Asp Lys 85
90 95Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys 100 105 110Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro 115 120 125Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys 130 135 140Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp145 150 155 160Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200
205Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Asp Glu225 230 235 240Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr 245 250 255Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn 260 265 270Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285Leu Tyr Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr305 310 315
320Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 3302345163DNAHomo
sapiens 234cagctgagat ctcctagagt cggtgaaggg tacaaagtaa aatacaatgt
cgtttgtagt 60gttgttagta aggatgtcta gtggtgacgt acactagtta ttttatcaaa
aacgttgtta 120ccatgaatac tattagtaga aaataacaaa tgtttatgac
gaaatgttat caataagcca 180acgtgacaag tataatctaa aggttaatcg
agtgaatcct tgtattcagg gagcttgtcg 240agtcagtaga aaaagtaagg
acaaagatag gggatgtaga gaaaggaaac gtctgctgat 300agaggatgtg
actttgtcct ttcgatcgaa aaaaaaaaag tcacgataaa ttaataaagt
360tataggagag tagtttacat aaatttattg ttttcgagtt cgtttttctt
tctttataca 420ttaagaaagt ctcattttta gtgtgggtac tggaccggtg
actcccgaac tagttaagtg 480aaacttaaac cgtaatttat ggtaattcca
tataattgac taaaatttta ttctatataa 540gcactggtac aaaaattgaa
agtttttaca tcgacggtca cacactaaaa taaagtcaac 600atgttttata
gatttggata tcgttacact aattattttt gaatttgtat aaaaggtcat
660ggaattaaga cactatcctt ttaaaattag actcataaaa ttaaagtatt
agagatttta 720tcaaattact aaacagtaac acaacgacag caaatgggtc
gactagagtt ttcactataa 780attcctctaa taaaaccaga cgttgttgaa
ctatcctgat aaaatcccgg aaaaatttcg 840agataatttt gattgaatgt
tgctaagttt tgacaaaatt tgataaagtt ttactaaaat 900ctcggaaaac
ttttgagaaa atttgtgaaa aatttgagat aattttgatt attctattga
960actttattaa aagtacagtt tatgtaattg acaaattaca aatttacggt
ctacttttta 1020catttcgata gtcttaagtg ggtctatcct catagaagta
tcgtacaaaa agggacgaat 1080aaaaggtcac tagtgtaata aaacgatggt
accaataaaa tatgttaata gacttttttt 1140aatcaatact tctaattttc
tcttctttta taatttgtat tctctaagtc agaaagtaca 1200acttgacgaa
ccaattgtca cttcaatcaa aatttttttt ttttttgata aagacaatag
1260tcgactgaag agggatagac aactgaagag ggtcgttttc taagaataaa
atgtaaaatt 1320gatgacgaga gggtgggttg cccaccttag ggggtctccc
cctaaaggtt ctccggtgga 1380ccgtcaacga ctcccagtct tcacttcgat
cggtgaagga gaatccgtcc accggttcta 1440atgtcaactg gagaggacca
taccgacttt taacgacgta taccaatgtc cggaactccg 1500gaaaccctcc
cgaatctctc aacgaccttg tcagtcttcc acctccccga ctgtggtggg
1560tccgcgtctc cgtcccgagt cccggacgag acgtccctaa ctgagtcggc
gacggaccag 1620aagaagtctg gacaagactt aagatttgag actcccccag
cctactgcac cggtaagaaa 1680cggatttcgt aactcaaatg acgttccagt
cttttcgtac gtttcgggag tcttaccgac 1740gtttctcgag gttgttttgt
taaatcttga aataattcct tatccccctt cgatccttct 1800ttgagttttg
tagttctaaa atttatgcga agaaccagag gaacgatatt aatagaccct
1860attcgtacga caaaagacag acagggaatg tacgggacac taataggcgt
ttgttgtgtg 1920ggttcccgtc ttgaaacaat gaatttgtgg taggacaaac
gaagaaagga gtccttgaca 1980ccgacgtggt agacagaagt agaagggcgg
tagactactc gtcaacttta gaccttgacg 2040gagacaacac acggacgact
tattgaagat agggtctctc cggtttcatg tcaccttcca 2100cctattgcgg
gaggttagcc cattgagggt cctctcacag tgtctcgtcc tgtcgttcct
2160gtcgtggatg tcggagtcgt cgtgggactg cgactcgttt cgtctgatgc
tctttgtgtt 2220tgagatgcgg acgcttcagt gggtagtccc ggactcgagc
gggcagtgtt tctcgaagtt 2280gtcccctctc acaatctccc tcttcacggg
ggtggacgag gagtcaaggt cggactgggg 2340gagggtagga aaccggagac
tgggaaaaag gtgtcccctg gatggggata acgccaggag 2400gtcgagtaga
aagtggagtg gggggaggag gaggaaccga aattaatacg attacaacct
2460cctcttactt atttatttca cttagaaacg tggacaccaa agagagaaag
gagtaaatta 2520ttaataatag acaacaaaat ggttgatgag ttaaagagaa
tattccctga tttatacatc 2580agtaggattc cgcgtattgg taaatatttt
tagtaggaag taagataaaa tgggatagta 2640ggagacgttc tgtcaggagg
gagtttgggt gttcggaaga caggagtgtc aggggacccg 2700gtaccatcct
ctctgaacga aggaacaaaa ggggaggagt cgttcgggag tatcaggaaa
2760aattcccact gtccagaatg tcagtatata ggaaactaag ttaagggact
cttagttggt 2820ttcgtttaaa aagttttctt ctttggacga tatttctctt
agtaagtaac gttgtactat 2880attttattgt tgtgttattt tcgttaattt
atttgtttgt tatcccttta caaattcaag 2940tagtaccatg aatctgaatt
accttacagt acggaataaa tgtaaaaatt tgtccatgac 3000tccctgagga
cagacggttc ccggcataac tcatgaaagg tgttgcatta aattaggtgt
3060gatatgacac tctaattttt gtaagtaatt ttacaacgtt tccaagatat
ttcgactctc 3120tgtttatata agatattgag tcgttagggt gaagatctac
tgactcacag gggtgggtgg 3180ttttttgata cgttcttaca agtttcgtcg
aaataaatgt tttcggtttt taacctttat 3240cgggctaaca ggttgttatc
ttactcaata atttgacacc atacaaatat gtaatcttat 3300gggttactcc
tcttaattgt tcgatgttga tatggatgag tgtgtctact tagagtattt
3360ttattacaat gtattctctt tgagttacgt tttctataca agacatacaa
aagtaggtat 3420atttcaagtt ttggtccatt tttatttcaa tctttaaacc
tacctttaat gagaatcgac 3480ccccacccgc tcaatcacgg accctcttct
gttcttcccc gaagacccca gaaccattac 3540aagacaagga gcacacccca
acacgtcaat actagacacg tgacaagaca tatgtgtaat 3600acgaagtttt
attgaagtgt atttcttgta gaatatgggt caattatcta tcttctcctt
3660attcattatc cagttctggt acgtcgacca ttcacccccc cggaccctag
tttatcgatg 3720gacggattag gacgggagaa ctcgggactt actcagacgg
aaggtcccga gttccacgag 3780ttgttttgtt gtccggacga taaaaggacc
gtagacacgg gacaaaccga tcgatcctcg 3840tgtgtatgta tctttaattt
actttgtctg gaagtcgttc ccctgtctcc tgtcttaatt 3900ggaacgggtc
tgtgaccttt gggtacatac ttgtgagtgt acaaaccctt cccccttccc
3960gtgtacattt actcctgaga aggagtaaga taccccgtga gaccgggacg
gggagagtcg 4020atgagtaggt aggttgtgtg gaaagattca tggagagaga
cggatgtgag acttccccaa 4080gtcctcattg attgtgtcgt agggaaggga
gtttactgac tggtagggaa acaggacgaa 4140acaaaaagaa aggtcagtca
tgaccctttc accccttcct gtcagtacct ttttgatgta 4200ttccttcgtg
gaacgggaag acggagaact cttacaacta ctcatagttt agaaagtttg
4260aaacctccaa actcatcccc actctgagtc attacaggga aggttactgt
acttgaacga 4320gtgagtaggg acccccggtt taacttgtta gtttccgtcc
gtattaggtc aatacttaag 4380tttggaagaa gagtcttcta ttgtgagact
tccctttggg tgggtattgg attcgttcac 4440ttctgtccac gacgtccacc
ttaacacagg aagtttttcc atacgagttg aggaacgaga 4500accatgagta
tttacccagt gtatttacac tgaaataaac ctttatccca gaaacgtctc
4560cattagttca gttttaatcc agtatgactt tacaaacact cctacgccac
ttttacctag 4620taagtatata acgaccaccc ttatattttc ccatatcgat
gagatctttt atcaacagtc 4680aaagaacttt ttgatttgtt ttctgtggat
ggtatactgg gtccttaaca tgaggaaccc 4740ttaaatgggg gtcctttatt
tttgaataca ggtgtgtctt gggtatgtac taacaagtgt 4800cgtcgaaata
aacaacatcg gtttcgatct ttctcggttg ggtagggagt tatccgttga
4860tcggattgtt taacattata taggtacggt atcttacgat actccgttat
ttttccttgc 4920ttcacaacta tgtctcttga cctcactaag acttcctgaa
agatgactca cttttttcgg 4980ttagactttc ccagtgtatg gtacactaag
gaaaatgcat tgtaacaact tcactgtttt 5040aatatcccta tctctgtgct
aagaccaacg gtccccaatc ccaccacccc tttcttctca 5100tctgctttga
tatttccctc taggggccca tggctcgagc ttaagtagct actatcgccg 5160gcg
5163235106PRTHomo sapiens 235Thr Val Ala Ala Pro Ser Val Phe Ile
Phe Pro Pro Ser Asp Glu Gln 1 5 10 15Leu Lys Ser Gly Thr Ala Ser
Val Val Cys Leu Leu Asn Asn Phe Tyr 20 25 30Pro Arg Glu Ala Lys Val
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 35 40 45Gly Asn Ser Gln Glu
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 50 55 60Tyr Ser Leu Ser
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 65 70 75 80His Lys
Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 85 90 95Val
Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105
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