U.S. patent application number 12/007503 was filed with the patent office on 2008-07-17 for method and apparatus for correlated ophthalmic measurements.
Invention is credited to Michael Davies, Gordon Freedman, Rejean J. Munger.
Application Number | 20080170205 12/007503 |
Document ID | / |
Family ID | 39617485 |
Filed Date | 2008-07-17 |
United States Patent
Application |
20080170205 |
Kind Code |
A1 |
Munger; Rejean J. ; et
al. |
July 17, 2008 |
Method and apparatus for correlated ophthalmic measurements
Abstract
A method and system providing multiple ophthalmic and retinal
blood measurements is outlined. By extracting multiple digitized
wavelength images and quantitative data within a relatively short
time period the method allows for compensation of a patients eye or
head movement, generation of ophthalmic clinical records, and
determination of data relating to blood measurements, such as
oxygen saturation and hemoglobin, in addition to ocular and other
disease determinations. The method provides for multiple analysis
and measurements within a single sitting of the patient, with a
single simple instrument and without adaptations to the instrument
during a patients eye examination. Beneficially the approach allows
for low cost, compact, and even portable implementations offering
such analysis and determination outside the current ophthalmic
centers providing eased access and earlier diagnosis
opportunities.
Inventors: |
Munger; Rejean J.; (Ottawa,
CA) ; Davies; Michael; (Ottawa, CA) ;
Freedman; Gordon; (Nepean, CA) |
Correspondence
Address: |
FREEDMAN & ASSOCIATES
117 CENTREPOINTE DRIVE, SUITE 350
NEPEAN, ONTARIO
K2G 5X3
omitted
|
Family ID: |
39617485 |
Appl. No.: |
12/007503 |
Filed: |
January 11, 2008 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
60879793 |
Jan 11, 2007 |
|
|
|
Current U.S.
Class: |
351/208 ;
351/221 |
Current CPC
Class: |
A61B 3/1233 20130101;
A61B 5/14555 20130101 |
Class at
Publication: |
351/208 ;
351/221 |
International
Class: |
A61B 3/15 20060101
A61B003/15; A61B 3/10 20060101 A61B003/10 |
Claims
1. A system comprising; an optical source, the optical source
comprising at least a control port, the optical source for
providing a source optical signal at least one of a plurality of
predetermined wavelengths, the one of the plurality of
predetermined wavelengths being established in dependence of a
control wavelength signal provided to the control port; a detector,
the detector comprising at least an output port, the detector for
receiving a detected optical signal, generating at least a digital
representation of a detected optical signal, and providing the
digital representation of a detected optical signal at the output
port as a detected electrical signal; an optical coupling, the
optical coupling for coupling the source optical signal to a
patients eyeball, receiving at least a signal returned from the
eyeball of the patient, and providing the reflected optical signal
to the detector, the reflected optical signal therefore forming at
least a portion of the detected optical signal; and, a controller,
the controller being electrically connected to at least the control
port and output port, the controller for providing at least one of
a plurality of control wavelength signals, receiving the detected
electrical signal, and providing a processed electrical signal, the
processed electrical signal being determined at least in dependence
upon the detected electrical signal, the control wavelength signal,
and a predetermined factor.
2. A system according to claim 1 wherein, the controller provides
at least two processed electrical signals during a single sitting
of the patient, the two processed electrical signals being provided
in response to the controller providing two different control
wavelength signals of the plurality of control wavelength
signals.
3. A system according to claim 1 wherein, the controller provides a
plurality of processed electrical signals, each of the plurality of
processed signals being at least one of dependent upon a different
characteristic of the patients eyeball and obtained without a
reconfiguration of the system other than providing at least a
subset of the plurality of optical wavelengths.
4. A system according to claim 3 wherein, receiving a signal
returned from the eyeball comprises receiving an optical signal
that is generated by at least one of scatter signal, specular
reflection, fluorescence, raman scattering, speckle signal, and
absorption in response to the provided a source optical signal.
5. A system according to claim 1 wherein, the optical source
comprises at least one of a tunable laser, an incandescent bulb, a
tunable optical filter, at least one of plurality of predetermined
optical filters, a spectrometer, and a multiple solid state light
emitting diode.
6. A system according to claim 1 wherein, the detector comprises at
least one of a photodetector and analog-to-digital converter, an
array of photodiodes and at least an analog-to-digital converter,
and a charge coupled device.
7. A system according to claim 1 wherein, the optical coupling
comprises at least one of a lens, a mirror a beam-splitter, a
wavelength filter, a rest and a restraint.
8. A system according to claim 7 wherein, at least one of the rest
and restraint provide a predetermined optical configuration of at
least the optical source detector, and patients eyeball.
9. A system according to claim 1 wherein, the optical coupling
provides a predetermined optical configuration of at least the
optical source, detector, and patients eyeball.
10. A system according to claim 1 further comprising; a memory, the
memory for storing at least the processed electrical signal.
11. A system according to claim 10 wherein, the memory comprises a
computer memory, a computer disk drive, a computer readable storage
medium, a memory drive, a memory chip, a smart card, and a
networked computer disk drive.
12. (canceled)
13. (canceled)
14. (canceled)
15. (canceled)
16. A method comprising; providing an ophthalmic instrument, the
ophthalmic instrument comprising at least a multi-wavelength
optical source, an optical wavelength filter, and a detector, the
ophthalmic instrument for providing a digital output determined in
dependence upon at least a state of the machine and the wavelength
of the multi-wavelength optical source; providing a rest, the rest
for providing a predetermined relationship between a patients head
engaged with at least the rest and the ophthalmic instrument; and,
determining with a single placement of the patients head with
respect to the ophthalmic instrument at least one measurement of a
plurality of measurements of the patient, each of the plurality of
measurements determined in dependence upon at least the digital
output.
17. A method according to claim 16 further comprising; determining
at least a second measurement of the plurality of measurements of
the patient, the second measurement being taken during the same
sitting of the patient.
18. A method according to claim 16 wherein, determining with a
single placement comprises providing no reconfiguration of the
ophthalmic instrument other than a change in the at least one of
the multi-wavelength optical source and the optical wavelength
filter.
19. A method according to claim 18 wherein, providing no
reconfiguration is other than providing an optical signal to the
patients head at one optical wavelength of a plurality of optical
wavelengths other than the current optical wavelength of the
plurality of optical wavelengths.
20. A method according to claim 16 further comprising; determining
at least a characteristic of a plurality of characteristics of the
patient, in dependence upon at least one of a predetermined portion
of the plurality of measurements of the patient and a state of the
ophthalmic instrument, the predetermined portion of the plurality
of measurements at least one of employed as is, employed with a
crop applied to reduce a dimension of each measurement, and
employed with an offset applied to align all measurements of the
plurality of measurements to a common feature.
21. A method according to claim 20 wherein, the plurality of
measurements generated in dependence upon an optical signal from
the multi-wavelength optical source relate to at least one of
providing the optical signal with a predetermined wavelength
sequence of a plurality of wavelengths, at a first predetermined
wavelength and multiple predetermined time intervals, and at a
second predetermined wavelength act as a probe followed by multiple
measurements at least one of predetermined time intervals and
predetermined wavelengths after the probe signal has been
applied.
22. A method according to claim 20 wherein, determining a
characteristic of the patient further comprises at least one of
applying a predetermined process to the plurality of measurements
of the patient, employing at least one measurement of the patient
from a previous testing of the patient and weighting the
determination in respect of a characteristic of the patient.
23. A method according to claim 20 wherein, determining a
characteristic of the patient at least in dependence upon the state
of the ophthalmic instrument comprises determining the
characteristic in dependence upon at least one of a mathematical
algorithm and a computer process, the at least one of mathematical
algorithm and computer process being different for each state of
the ophthalmic instrument.
24. A method according to claim 16 farther comprising; storing the
at least one characteristic of a plurality of characteristics of
the patient.
25. A method according to claim 21 wherein, storing the at least
one characteristic comprises storing at least one of the output of
the detector for a predetermined subset of the plurality of
wavelengths and the result of a process applied to the output of
the detector.
26. A method according to claim 24 wherein, storing the
characteristic comprises storing the characteristic in at least one
of a computer memory, a computer disk drive, a computer readable
storage medium, a memory drive, a memory chip, a smart card, and a
networked computer disk drive.
27. A method according to claim 24 further comprising; providing
the at least one characteristic of a plurality of characteristics
of the patient to at least an operator of the ophthalmic
instrument.
28. A method according to claim 24 wherein, providing to at least
an operator comprises providing at least one of a visual
representation, a text representation, a numerical representation,
and a graphical representation of the characteristic to the
operator.
29. A method according to claim 24 wherein, providing the at least
one representation further comprises providing at least an
indication of an anomaly within the at least one of the
characteristic and the plurality of characteristics.
Description
[0001] This application claims the benefit of U.S. Provisional
Application No. 60/879,793, filed on Jan. 11, 2007, the entire
content of which is incorporated herein by reference.
FIELD OF THE INVENTION
[0002] The invention relates to ophthalmic analysis and more
particularly to using time and wavelength based imaging to provide
multiple analyses with reduced constraints on equipment and
patient.
BACKGROUND OF THE INVENTION
[0003] Historically, visits to an ophthalmic specialist or eye
center were based upon obtaining a measure of the patients reading
quality as a function of distance, color and text dimension. Then
based upon these the patient was assessed using a wide variety of
graduated lenses to provide a simple three value characterization
for each eye of the appropriate lens to correct for common visual
defects such as shortsightedness, long-sightedness, and peripheral
focus.
[0004] In recent years an important trend in such visitations to an
ophthalmic center has been the addition of a limited number of
diagnosis for the early onset of conditions such as diabetes.
Generally, each such diagnostic addition is performed by
provisioning of a further evaluation station within the ophthalmic
center such that the patient moved along with the ophthalmetrist to
each evaluation station in turn. At each station the patient is
required to hold their head in a steady position within a
restraint, and to keep their eye open for extended periods whilst
the ophthalmetrist assessed their health or visual acuity.
[0005] Such a requirement for multiple evaluation stations places
constraints on the provisioning of such ophthalmic tests for
patients to locations with significant floor area, requires the
centers providing the services to invest heavily in capital
equipment, and provides a psychological barrier to patients in
having frequent check-ups and assessments. More significantly, a
single file must pass from system to system for storing of results
therein or data of one patient ends up in another patients file.
Management of patient data is important if screening tests are to
be meaningful.
[0006] One approach to managing patient data is to test a single
patient at a time. In such a situation, all systems are unused
except one. This is an inefficient use of resources. Unfortunately,
for a very efficient use of resources, file management becomes
extremely difficult with several tests performed on different
patients in parallel.
[0007] It would therefore be beneficial to provide an ophthalmic
instrument that allowed a plurality of ophthalmic tests to be
performed upon a patient in a single sitting with a single sequence
of measurements that did not require reconfiguration of the
ophthalmic instrument during the sitting. Advantageously, such a
single sequence of measurements provides for a correlation of
results from these different measurements and allows for the
incorporation of weightings or adjustments into the analysis of one
characteristic based upon measurements and analysis of another
characteristic. This being possible as these measurements are now
associated with defined time differences, the time between
measurements being reduced with such a single setting and single
sequence of ophthalmic measurements, and the conditions of the
measurements being more consistent than moving a patient between
multiple test stations over an extended period of time.
[0008] Advantageously, where there correlation between measurements
is of increased interest then the sequence of tests within the
ophthalmic instrument can be changed simply, such as with software
reconfiguration of the testing sequence. Further, the ability to
provide consistent time differences between different measurements
allows improved correlation of the measurements not only within a
single sitting but across the multiple sittings of a patient over
time with their repeat visits. Additionally, the defined time
stamps of the different measurements allows the subsequent analysis
of the measurement data for an additional or new characteristic at
a later date, a potential which today does not exist.
[0009] Additionally, automating multiple measurements within a
single sitting provides opportunities to expand the provisioning of
the tests based upon ophthalmic measurements, including but not
limited to, blood flow, oxygen saturation, deployed outside
ophthalmic centers into doctor's offices, dentists, and even wider
providing enhanced diagnosis and early identification of diseases
or conditions thereby lowering health care expenditures and
potentially saving lives.
[0010] It is therefore an object of this invention to provide such
a beneficial method of providing within a single sitting multiple
ophthalmic measurements providing enhanced correlation of the
measurements and analysis.
SUMMARY OF THE INVENTION
[0011] In accordance with the invention there is provided a system
for performing ophthalmic measurements comprising an optical
source, the optical source comprising at least a control port, the
optical source for providing a source optical signal at least one
of a plurality of predetermined wavelengths, the one of the
plurality of predetermined wavelengths being established in
dependence of a control wavelength signal provided to the control
port. Also provided is a digital detector, the digital detector
comprising at least an output port, the digital detector for
receiving a detected optical signal, generating at least a digital
representation of a detected optical signal, and providing the
digital representation of a detected optical signal at the output
port as a detected electrical signal. An optical coupling is
provided for coupling the source optical signal to a patients
eyeball, receiving at least a reflected signal to an eyeball of the
patient, and providing the reflected optical signal to the digital
detector, the reflected optical signal therefore forming at least a
portion of the detected optical signal.
[0012] Also provided is a controller, the controller being
electrically connected to at least the control port and output
port, the controller for providing at least one of a plurality of
control wavelength signals, receiving the detected electrical
signal, and providing a processed electrical signal, the processed
electrical signal being determined at least in dependence upon the
detected electrical signal, the control wavelength signal, and a
predetermined factor.
[0013] In accordance with another aspect of the invention there is
provided a method of providing an ophthalmic instrument, comprising
at least a multi-wavelength optical source, an optical wavelength
filter, and a digital detector. The ophthalmic instrument for
providing a digital output determined in dependence upon at least a
state of the machine and the wavelength of the multi-wavelength
optical source. There is also provided a rest, the rest for
providing a predetermined relationship between a patients head
engaged with at least the rest and the ophthalmic instrument; and
thereby determining with a single placement of the patients head
with respect to the ophthalmic instrument at least one of a
plurality of measurements of the patient, the measurements
determined in dependence upon at least one digital output.
BRIEF DESCRIPTION OF THE DRAWINGS
[0014] Exemplary embodiments of the invention will now be described
in conjunction with the following drawings, in which:
[0015] FIG. 1 illustrates a schematic of an exemplary ophthalmic
system according to the invention.
[0016] FIG. 2 illustrates an exemplary visualization of the retinal
reflections as exploited by an exemplary embodiment of the
invention for providing an oxygen saturation measurement without
calibration.
[0017] FIG. 3 illustrates an exemplary flow chart for providing an
hemoximeter functionality within an exemplary embodiment of the
invention for hemoglobin measurements.
DETAILED DESCRIPTION OF EMBODIMENTS OF THE INVENTION
[0018] Referring to FIG. 1 shown is a schematic of an exemplary
ophthalmic system 100 according to the invention. Shown within the
ophthalmic system 100 are an optical source 130 capable of
providing light at the wavelengths necessary for the tests to be
performed with the images and data extracted using the ophthalmic
system 100. Such a light source typically being a tungsten lamp for
high efficiency, high optical illumination and broad wavelength
provisioning.
[0019] The emission from the optical source 130 is collimated using
first lens 125 and coupled to a wavelength filter element 120 that
selects the wavelength for a measurement to be performed. As shown
the wavelength filter element 120 and optical source 125 are
electrically interconnected to a central controller 140 which
provides for management of the wavelength filter element 120 and
optical source 125 during the measurement procedures under control
of software operating upon a microprocessor, not shown for clarity
but optionally embedded within the central controller 140.
[0020] The output light of the wavelength filter element 120, being
a wavelength slice of the emission from the optical source 130 is
coupled via optical element 115 to the second lens 110 wherein it
is coupled to the patients eyeball 150 via their corneal lens 105.
Light reflected from the retina 160 of the patient's eyeball 150 is
then coupled back through the corneal lens 105 and second lens 110
to the optical element 115. Optical element 115 provides the
functionality of a beam splitter in that the reflected light
impinging onto the optical element now exits from a port of the
optical element that is not the same as the light initially
coupling into the optical element 115 from the optical source 130.
In this manner the reflected signal is isolated from the optical
source 130. The reflected signal upon exiting the optical element
115 is coupled to the CCD array 155.
[0021] The CCD array 155 is electrically coupled to the central
controller 140 allowing the image of the patient's retina 160 to be
extracted. In this exemplary embodiment the extracted CCD image is
provided either to a display 135 or a storage device 145. It would
be evident to one skilled in the art that the CCD data may be
handled in many different manners, including but not limited to
being stored without processing, stored with processing, displayed
with processing, processed in conjunction with an algorithm stored
within the central controller, processed in conjunction with other
wavelength images, have qualitative data extracted from the image,
and have qualitative data extracted in dependence upon multiple
extractions with varying optical source intensity. Further, the CCD
image may be processed such that for all wavelengths extracts the
images are aligned within a predetermined image template according
to a physically extracted feature of an image. In this manner the
ophthalmic system 100 allows for movement of the patients eyeball
150 during a sequence of multiple images either from motion of the
patients eyeball 150 itself or the patients head, not shown for
clarity.
[0022] An exemplary embodiment of the use of an ophthalmic system
100 as presented in respect of FIG. 1 is now described for an
oxygen saturation measurement without calibration. The model
describing the light reflection and absorption by the different
layers in the human eye in this exemplary embodiment was adopted
from the early model developed by van Norren & Tiemeijer (1986)
and Delori & Pflibsen (1989). A similar model, which further
includes the receptor layer ignored in earlier models, was
presented by van de Kraats, Berendschot & van Norren (1996) and
Faubert & Diaconu (2001) and may be optionally employed in this
determination. In this model, as shown schematically in FIG. 2 the
pigment epithelium 290 and the sclera 270 are the principal
reflectance layers and the eye media 240, macular pigment 280,
melanin 275, photoreceptor photo pigments 230, together with
hemoglobin and oxygenated hemoglobin represent layers where light
is absorbed.
[0023] According to FIG. 2, an incident light of intensity
I0.lamda.), we obtain a reflected light with two components: one
from the pigment epithelium layer 290 and one from the sclera 270 A
mathematical description is shown by the following equations (1)
and (2)
IR1(.lamda.)=I0(.lamda.)*10.sup.-2(D1(.lamda.)+D2(.lamda.)+Dp(.lamda.))*-
R1(.lamda.)*C(.lamda.) (1)
IR2(.lamda.)=I0(.lamda.)*10.sup.-2(D1(.lamda.)+D2(.lamda.)+Dp(.lamda.)+D-
3(.lamda.)+D4(.lamda.)+D5(.lamda.))*R2(.lamda.)*(1-R1(.lamda.)).sup.2C(.OM-
EGA.) (2)
[0024] Where I.sub.R1(.lamda.) represents the spectral flux
reflected by the pigment epithelium 290 the I.sub.R2(.lamda.)
represents the spectral flux reflected by the sclera 270. The
constant C(.OMEGA.) represents that only a small fraction of the
reflected light exiting through the solid angle of the fundus point
and the pupil surface. For human eye dimensions and for a typical
pupil of 4 mm in diameter, we can assume that C(.lamda.) equals
10.sup.-2.
[0025] The reflection coefficients of the epithelium and the sclera
are represented by the R.sub.1(.lamda.) and R.sub.2(.lamda.)
respectively. In the equation (2) the expression
(1-R.sub.1(.lamda.)).sup.2 determines that the reflected light from
the sclera 270 supports two partial reflections from the epithelium
layer 290. The different absorbing layers are represented in the
formulas by the values Di(.lamda.) for optical spectral density.
For a homogeneous medium, the optical spectral density can be
described by the following formula:
D(.lamda.)=.epsilon.(.lamda.)*d*c (3)
[0026] where E(.lamda.) represents the spectral extinction
coefficient, d is the optical path length of the light in the
absorbing layer, and c is the concentration of the absorbing
molecules in the medium. In this exemplary embodiment the optical
density of different layers in the eye has been assumed to be
expressed by a function F(.lamda.) that is constant across
subjects, i.e. the normalized spectral density function is
constant, multiplied by a subject dependent coefficient m:
D=F(.lamda.)*m (4)
[0027] where m varies as a function of optical path length d and
concentration c.
[0028] Hence, from Equations (1) and (2) we can express the
reflected light from the fundus of the eye as:
IR(.lamda.)=IR1(.lamda.)+IR2(.lamda.) (5a)
and
IR(.lamda.)=I0*10.sup.-2(D1(.lamda.)+D2(.lamda.)+Dp(.lamda.)*[R1(.lamda.-
)+10.sup.-2(D3(.lamda.)+D4(.lamda.)+D5(.lamda.))*R2*(1-R1)2]*C(.OMEGA.)
(5b)
[0029] Now using the expression: D(.lamda.)=F*m for the optical
density we can rewrite the equation (5b) as:
IR ( .lamda. . ) = I 0 ( .lamda. . ) * 10 - 2 ( F 1 ( .lamda. ) m 1
+ F 2 ( .lamda. ) m 2 + Fp ( .lamda. ) mp ) * [ R 1 ( .lamda. ) +
10 - 2 ( F 3 ( .lamda. ) m 3 + F 4 ( .lamda. ) m 4 + f 5 ( .lamda.
) ) m 5 * R 2 ( .lamda. . ) * ( 1 - R 1 ( .lamda. . ) ) 2 ] * C (
.OMEGA. ) ( 6 ) ##EQU00001##
[0030] When the ophthalmic system 100 of FIG. 1 is capable of
providing a significant number of wavelengths, within the visible
region of the spectrum between approximately 380 nm and 720 nm,
then a sufficient number of measurements are provided allowing a
solution to the unknown m.sub.i values to be obtained from the
multiple simultaneous equations (6). Further, from these multiple
measurements estimates of the F.sub.i(.lamda.) and Ri(.lamda.)
spectral absorption, and the spectral reflection functions for each
optical layer in the eye may be determined. It would be evident to
one skilled in the art that using determination of oxygen
saturation in retinal vessel proves to be very difficult when a
limited numbers of measured wavelengths are used. However, with
rapid tunable filters and fast CCDs obtaining such measurements is
fast.
[0031] Further, having digital data allows the process to correct
for issues such as movement of the patients retina, variations in
optical source intensity etc. It would therefore be apparent to one
skilled in the art that the approach provides for fast, accurate
and reproducible evaluation and analysis of ocular data. Further,
having time dependent wavelength data within a relatively short
time period provides for correction of other factors.
[0032] Additionally, it would be apparent that upon a subsequent
examination of the patient the extracted data provides for
historical clinical records, which are typically not available for
patient's retina, unless they have unusually had images taken due
to their exposure to laser sources etc. Anomalies in wavelength
dependency are optionally highlighted rapidly prior to detailed
analysis, images may be optionally presented to an ophthalmic
specialist as color coded variances from a previous evaluation, or
a new algorithm may be employed to analyze previously stored
records.
[0033] Hence, if we consider that a new technique for measuring
hemoglobin is established with six wavelengths, being 535, 560,
577, 622, 636, and 670 nm, and that these are within the datasets
stored for a patient then upon adding a new analysis algorithm to
the ophthalmic system 100 the patients hemoglobin data may be
historically extracted. It would be evident this is advantageous in
expanding clinical records on patients with evolving knowledge in
the medical field, and allows subsequent analysis of clinical
records to establish previously undetected conditions or determine
timing of an onset of a condition or disease.
[0034] Referring to FIG. 3 an exemplary flow diagram for an
exemplary ophthalmic system 100 is shown providing an hemoximeter
functionality to determine the concentration of hemoglobin (Hb),
oxygenated Hb, carbon monoxide bound Hb, metallic bound Hb, and
sulfurated Hb for the patient's blood using ocular image data.
[0035] As shown the process starts at step 301 with the loading of
an algorithm to control the ophthalmic system. At step 302 the
number of wavelengths to be measured is established from the
algorithm, and at step 303 a counter M is set to 1 for the initial
measurement. At step 304 a wavelength filter is set to the first
wavelength, which may be a wavelength target extracted from a
database in reference to the algorithm and the counter M. At step
305 the ophthalmic system captures the image of the patients retina
and in step 306 stores the extracted image.
[0036] At step 307 the algorithm establishes whether it has
completed the imaging process or not. If there are additional
wavelengths to be captured then the ophthalmic system returns via
step 308 to step 304 in cyclic manner until the sequence is
completed. At this point ophthalmic system algorithm resets the
counter M to 1. Now the algorithm proceeds to a second analysis
sequence starting at step 311 where the first wavelength image is
extracted and a physical element within the image identified.
[0037] At step 312 the algorithm aligns the extracted image to a
predetermined image frame using the physical element identified.
Then at step 313 key quantitative data is extracted from the image.
At step 314 the algorithm establishes whether it has completed the
analysis process or not. If there are additional wavelengths to be
captured then the ophthalmic system returns via step 309 to step
311 in cyclic manner until the sequence is completed. In this
exemplary algorithm the physical element alignment of each
wavelength image allows the movement of the patients eyeball to be
removed from the images.
[0038] At step 315 a software calculation of the blood factor of
interest is undertaken using the extracted quantitative data at
steps 313 from the wavelength images. Next the algorithm at 316
adapts a merged image file, determined in this example by additive
addition of all image files, for the blood factor. At step 317 the
resulting data is formatted and presented to the patient, operator,
or ophthalmic specialist as defined by the algorithm before ending
at step 318. Such presentation of resulting data may be tabulated
data, image data, manipulated image data etc. An option within step
316 is to adjust the images according to the result of an analysis
such that a presented image highlights a detected abnormality in
results as well as the tabulated data.
[0039] It would be apparent to one skilled in the art that such
digitally extracted image data can be stored not only centrally
within an ophthalmic centers databases but may also be stored
within a smart card embedded within a patients health card. Such
data may be beneficially extracted and analyzed for oxygen
saturation in retinal arteries and retinal veins for example during
a surgery in trauma and emergency environments to enhance the
trauma teams knowledge of the patients normal oxygen saturation and
whether ocular measurements in trauma environments are abnormal or
not. It would be further apparent that a low cost, portable variant
of the ophthalmic system 100 is possible allowing its use in remote
environments, within trauma rooms, within wards, etc as well as the
more conventional environments for performing routine analysis and
assessment of patients.
[0040] Beneficially, the method and system presented allow for
multiple ophthalmic tests and measurements to be performed from a
single instrument, in a single location, without requiring the
insertion/removal of multiple test elements and equipment, whilst
allowing improved patient ergonomics as the system can compensate
for limited eye or head movements during the tests. Further, use of
relatively fast and low cost elements provides a multiple test
system that optionally performs these measurements in less time
than a traditional single examination test of the prior art
approaches.
[0041] Numerous other embodiments may be envisaged without
departing from the spirit or scope of the invention.
* * * * *