U.S. patent application number 11/976103 was filed with the patent office on 2008-05-08 for array system and method for locating an in vivo signal source.
Invention is credited to Mordechai Frisch, Arkady Glukhovsky, Daphna Levy.
Application Number | 20080108872 11/976103 |
Document ID | / |
Family ID | 11075419 |
Filed Date | 2008-05-08 |
United States Patent
Application |
20080108872 |
Kind Code |
A1 |
Glukhovsky; Arkady ; et
al. |
May 8, 2008 |
Array system and method for locating an in vivo signal source
Abstract
A system and method for localizing an in vivo signal source
using a wearable antenna array having at least two antenna
elements. The signal is received and a signal strength is measured
at two or more antenna elements. An estimated coordinate set is
derived from the signal strength measurements.
Inventors: |
Glukhovsky; Arkady; (Nesher,
IL) ; Frisch; Mordechai; (Moreshet, IL) ;
Levy; Daphna; (Carmiel, IL) |
Correspondence
Address: |
Pearl Cohen Zedek Latzer, LLP
1500 Broadway
12th Floor
New York
NY
10036
US
|
Family ID: |
11075419 |
Appl. No.: |
11/976103 |
Filed: |
October 22, 2007 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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11073633 |
Mar 8, 2005 |
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11976103 |
Oct 22, 2007 |
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10150018 |
May 20, 2002 |
6904308 |
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11073633 |
Mar 8, 2005 |
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Current U.S.
Class: |
600/117 |
Current CPC
Class: |
A61B 5/06 20130101; A61B
5/0031 20130101; A61B 1/041 20130101; A61B 5/064 20130101; A61B
5/073 20130101; A61B 5/061 20130101; A61B 5/065 20130101; A61B
1/00016 20130101; A61B 5/0008 20130101 |
Class at
Publication: |
600/117 |
International
Class: |
A61B 1/00 20060101
A61B001/00 |
Foreign Application Data
Date |
Code |
Application Number |
May 20, 2001 |
IL |
143260 |
Claims
1. A method for localizing an ingestible in-vivo capsule within a
body lumen within a body, said method comprising the steps of:
positioning at least two antenna elements on the body, at least one
of the antenna elements positioned above the navel, receiving a
signal at two or more of said antenna elements; measuring the
received signal strength; and estimating the location of the
capsule based on the signal strength measurements.
2. The method according to claim 1 comprising positioning at least
one of the antenna elements in a position within the group
consisting of: the intersection of the right 7th intercostal space
and right mid clavicular line, the xiphoid process, the
intersection of the left 7th intercostal space and left mid
clavicular line, the right lumbar region at umbilical level, the
left lumbar region at umbilical level, the right mid-linguinal
region, and the left mid-linguinal region.
3. The method according to claim 1, further comprising the step of
calculating a distance value associated with a received signal.
4. The method according to claim 3, further comprising the step of
correlating the location of the capsule using the distance values
associated with two or more antenna elements.
5. The method according to claim 1, further comprising the step of
displaying the capsule's estimated location.
6. The method according to claim 1, comprising displaying the
capsule's estimated location graphically as a pointer with a figure
of a body.
7. A method for receiving a signal from an ingestible in-vivo
capsule, said capsule being within a body lumen, the method
comprising: positioning a first antenna element at the intersection
of the right 7th intercostal space and right mid lavicular line,
positioning a second antenna element at the xiphoid process,
positioning a third antenna element at the intersection of the left
7th intercostal space and left mid clavicular line, positioning a
fourth antenna element at the right lumbar region at umbilical
level, positioning a fifth antenna element at the left lumbar
region at umbilical level, positioning a sixth antenna element at
the right mid-linguinal region, positioning a seventh antenna
element at the left mid-linguinal region, and positioning an eighth
antenna element above the navel.
8. The method according to claim 7 wherein the antenna elements are
included in a wearable antenna array.
Description
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation of U.S. patent
application Ser. No. 11/073,633, filed Mar. 8, 2005, which is a
continuation of U.S. patent application Ser. No. 10/150,018, filed
May 20, 2002, which claims the benefit of Israel Patent Application
No. 143260 filed May 20, 2001, all of which being incorporated by
reference herein in their entirety.
FIELD OF THE INVENTION
[0002] The present invention relates generally to an in vivo camera
system and in particular to a system and method for identifying the
position of such an in vivo camera system.
BACKGROUND OF THE INVENTION
[0003] Various in vivo measurement systems are known in the art.
They typically include ingestible electronic capsules which collect
data and which transmit the data to a receiver system. These
capsules, which are moved through the digestive system by
peristalsis, include "Heidelberg" capsules to measure pH,
"CoreTemp" capsules to measure temperature and other capsules to
measure pressure throughout the intestines. They have also been
used to measure gastric residence time and intestinal passage time,
which is the time it takes for food to pass through the stomach and
intestines.
[0004] The intestinal capsules typically include a measuring system
and a transmission system, where the transmission system transmits
the measured data at radio frequencies to the receiver system.
Alternate systems can store all the data within a storage device in
the capsule. The data can then be read after the capsule exits the
gastro-intestinal (GI) tract.
[0005] In vivo camera systems are known, such one known camera
system which is carried by a swallowable capsule. The in vivo video
camera system captures and transmits images of the GI tract while
the capsule passes through the gastro-intestinal lumen. The system
includes a capsule that can pass through the entire digestive tract
and operate as an autonomous video endoscope.
[0006] Prior attempts at localizing an intra-gastric and
intrauterine transmitting capsule includes spatially scanning a
non-ambulatory patient with a receiver. The receiver and scanning
system locates the points with the highest reception and plots a
track of the capsule, the assumption being that the capsule is at
the location where the strongest signal is received. These attempts
use a laboratory device that is non-portable and
non-commercial.
[0007] Other attempts at localizing an in vivo capsule analyze the
statistics of signal variation during the passage of the capsule
through the GI tract. Large signal level variations are observable
during the passage of the capsule through specific significant
locations in the lumen and these variations are associated with
specific anatomical features. This method is inherently inaccurate
since the anatomically significant locations of the GI tract are
not rigidly attached to a fixed frame of reference.
SUMMARY OF THE INVENTION
[0008] As part of the present invention, there is an antenna array
having multiple antenna elements. The antenna array may be fixed to
a body, and two or more antenna element may receive a signal from
an in vivo signal source. A signal strength of a received signal
may be measured and an estimated location of the signal source may
be derived from the signal strength measurements.
BRIEF DESCRIPTION OF THE DRAWINGS
[0009] The subject matter regarded as the invention is particularly
pointed out and distinctly claimed in the concluding portion of the
specification. The invention, however, both as to organization and
method of operation, together with containers, features, and
advantages thereof, may best be understood by reference to the
following detailed description when read with the accompanying
drawings in which:
[0010] FIGS. 1A and 1B show a person wearing an antenna array
according to an embodiment of the present invention;
[0011] FIG. 2. shows a data recorder according to an embodiment of
the present invention.
[0012] FIG. 3. shows an in vivo signal source according to an
embodiment of the present invention.
[0013] FIG. 4. shows a torso wearing an antenna array according to
an embodiment of the present invention and an estimated point of a
signal source;
[0014] FIG. 5. shows a three signal vectors in a two dimensional
plane;
[0015] FIG. 6. shows a three signal vectors in three dimensional
space; and
[0016] FIG. 7. shows a graph of a weighing function for signal
vectors.
[0017] It will be appreciated that for simplicity and clarity of
illustration, elements shown in the figures have not necessarily
been drawn to scale. For example, the dimensions of some of the
elements may be exaggerated relative to other elements for clarity.
Further, where considered appropriate, reference numerals may be
repeated among the figures to indicate corresponding or analogous
elements.
DETAILED DESCRIPTION OF THE INVENTION
[0018] In the following detailed description, numerous specific
details are set forth in order to provide a thorough understanding
of the invention. However, it will be understood by those skilled
in the art that the present invention may be practiced without
these specific details. In other instances, well-known methods,
procedures, components and circuits have not been described in
detail so as not to obscure the present invention.
[0019] Unless specifically stated otherwise, as apparent from the
following discussions, it is appreciated that throughout the
specification discussions utilizing terms such as "processing",
"computing", "calculating", "determining", or the like, refer to
the action and/or processes of a computer or computing system, or
similar electronic computing device, that manipulate and/or
transform data represented as physical, such as electronic,
quantities within the computing system's registers and/or memories
into other data similarly represented as physical quantities within
is the computing system's memories, registers or other such
information storage, transmission or display devices.
[0020] Embodiments of the present invention may include apparatuses
for performing the operations herein. This apparatus may be
specially constructed for the desired purposes, or it may comprise
a general purpose computer selectively activated or reconfigured by
a computer program stored in the computer. Such a computer program
may be stored in a computer readable storage medium, such as, but
is not limited to, any type of disk including floppy disks, optical
disks, CD-ROMs, magnetic-optical disks, read-only memories (ROMs),
random access memories (RAMs) electrically programmable read-only
memories (EPROMs), electrically erasable and programmable read only
memories (EEPROMs), magnetic or optical cards, or any other type of
media suitable for storing electronic instructions, and capable of
being coupled to a computer system bus.
[0021] The processes and displays presented herein are not
inherently related to any particular computer or other apparatus.
Various general purpose systems may be used with programs in
accordance with the teachings herein, or it may prove convenient to
construct a more specialized apparatus to perform the desired
method. The desired structure for a variety of these systems will
appear from the description below. In addition, embodiments of the
present invention are not described with reference to any
particular programming language. It will be appreciated that a
variety of programming languages may be used to implement the
teachings of the inventions as described herein.
[0022] Reference is now made to FIGS. 1A and 1B. As part of the
present invention, an in vivo signal source may be localized using
a wearable antenna array or antenna array belt 10, as shown in
FIGS. 1A and 1B. The antenna array belt 10 is fitted such that it
may be wrapped around a patient and attached to a signal recorder
20. Additional embodiments include antenna elements having
adhesive, which may adhere the element to a point on a body. Each
of the antennas elements 10a through 10z in the array may connect
via coaxial cables to a connector, which connects to the recorder
20. Each antenna element 10a through 10z may be a loop antenna, or
may be any other antenna configuration known in the art.
[0023] In one embodiment the antenna array belt includes eight
antenna elements that are typically positioned on a subject's
midsection. For example, the antenna elements can be positioned as
follows. A first antenna element is positioned on the intersection
of the right 7.sup.th intercostal space and right mid clavicular
line; a second antenna element is positioned on the xiphoid
process; a third antenna element is positioned on the intersection
of the left 7.sup.th intercostal space and left mid clavicular
line; a fourth antenna element is positioned on the right lumbar
region at umbilical level; a fifth antenna element is positioned
above the naval; a sixth antenna element is positioned on the left
lumbar region at umbilical level; a seventh antenna element is
positioned on the right mid-linguinal region; and an eighth antenna
element is positioned on the left mid-linguinal region. Other
antenna positions and other numbers of antennas may be used. For
example, an antenna array may be positioned on a subjects back.
[0024] Aside from having a data storage unit 22, the data recorder
20 may also have a receiver 21, a signal strength measurement unit
24, a processing unit 26, and an antenna selector 25 as shown in
FIG. 2. In alternate embodiments the data recorder 20 may include
other combinations of components, and the components described may
be divided among other units. The signal strength measurement unit
24 may measure the signal strength of signals received by the
receiver 21 from each of the antenna elements 10a through 10z, and
the processing unit 26 may perform calculations to correlate the
received signal with an estimated location of the source of the
signal. The antenna selector 25 may open a signal path to single
antenna element from which the receiver 21 will receive a signal.
The antenna selector 25 may be adjusted to scan through all or
subset of antenna elements 10a through 10z. The scan rate and
pattern may be adjusted to maximize signal to noise ratios for the
received signals.
[0025] Turning now to FIG. 3, there is shown an example of an in
vivo signal source 100 according to one embodiment of the present
invention. The source 100 is a capsule, which may be ingested. The
capsule 100 may contain several sensors such as temperature 110a,
PH 110b, and optical 110c. Other sensors or sets of sensors may be
used. The sensors 110 may provide data, for example, to a data
transmitter 120. A beacon 130 may send out an intermittent beacon
signal, or the beacon 130 may be instructed to transmit at or about
the same time the data transmitter 120 transmits a data signal.
Typically, the data transmitter 120 will transmit at a higher
frequency than the beacon 130, but need not. In one embodiment of
the present invention the data transmitter 120 may transmit a
non-modulated signal as a beacon signal. In one embodiment the
capsule is similar to or may comprise components similar to
embodiments described in the art.
[0026] Turing now to FIG. 4, there is shown a dose-up of a human
torso wearing a belt 10 or adhesive antenna array according to an
embodiment of the present invention. Also visible is an estimated
location of an in vivo signal source 100. The location is shown as
the intersection point of three circles having radius R1, R2 and
R3. Each radius value being an estimated distance value of the
source 100 from each of antenna elements 10k, 10f and 10g,
receptively. The distance values may be calculated by the
processing unit 26 based on signal strength measurements preformed
by signal strength measurement unit 24. For example, the
propagation assumption used in processing the localization signal
data assumes that radiation attenuation is linear within the body.
This is equivalent to I.sub.r=I.sub.o?.alpha.*r, (Eq. 1)
[0027] where r is the distance (in cm) between the capsule and the
antenna, I.sub.o is the signal level (in dBm) at the capsule,
I.sub.r is the signal level (in dBm) at r, and .alpha. is the
absorption coefficient (in dB/cm). The assumption of linear
attenuation is valid at the working frequency range (200-500 MHz)
and at intermediate distances between the transmitter and receiver,
i.e. for distances of half a wavelength to 2-2.5 wavelengths.
Knowing the signal level at the source and the measured signal
level at each antenna, one can derive the distance between the
source and the antenna.
[0028] General signal source triangulation techniques as shown in
FIG. 4 are well known. For purposed of completeness, however, the
following is yet another example of a method of estimating the
location of an in vivo signal source according to the present
invention.
[0029] Shown in FIG. 5 are three signal vectors relating to signals
received at three antenna elements 10d, 10p, 10q. Beginning at the
origin of a coordinate system centered at the naval, each signal
vector points in the direction of its respective antenna element
and has a magnitude relating to the strength of the received
signal. Each signal vector may be calculated as the product of a
pointing vector from the origin to the point where its respective
antenna element is placed, multiplied by a normalized received
signal value. A normalized signal strength value may be computed by
dividing each measured signal strength value by the strongest
measured value. This results in the strongest measured value being
normalized to 1, and the rest to values smaller than one. Thus, the
signal vector pointing to an antenna element receiving the
strongest signal level will look identical to its pointing vector.
The other signal vectors will be shorter than their pointing
vectors.
[0030] The estimated point or location of the signal source 100 may
be estimated as the vector sum of all the signal strength vectors,
the location vector. Signal vectors may be calculated for two or
more antenna elements 10a through 10z. Signal vectors can be
calculated for only elements placed at the front of the torso, or
as FIG. 6 shows, signal vectors may also be calculated for elements
placed at the back of the body (FIG. 1B). The point estimated to be
the location of the signal source 100 in FIG. 6 is within the body.
Typically, the location vector starts at the origin of a three
dimensional system and ends at a point within the body.
[0031] As part of the present invention, one may use an absolute
coordinate set where points on the body are measured in terms of
standard units such as centimeters or inches. Alternatively, one
can assign values relative to anatomical points on the body and
later normalize the results. For example, an antenna element placed
at the naval may be given the coordinate set 0,0; an element placed
at the right end of the torso at naval level may be given the
coordinate set 5,0; and an element place at left end of the torso
-5,0. Distance values or vector magnitudes can be calculated using
these coordinate sets. And later the values may be proportionally
adjusted to fit the body's actual dimensions. For example, if there
was calculated a distance value of 2.5 inches based on the above
stated coordinates, but it was later measured that the body was
actually 7 unit from naval to the right end, the distance value of
2.5 could be adjusted in the same proportion, 7/5.
[0032] Only the two or three strongest signal sources may be used,
rejecting the weaker signal strength values, to calculate signal
vectors or distance values upon which a location estimate is based.
Once the strongest group of signals is identified, a second signal
strength measurement may be performed. The processing unit may be
adapted to perform a conventional vector sum operation on a subset
of the largest vectors, and to perform a weighted sum operation on
the signal vectors which are relatively smaller. Other
manipulations of the collected signals may be used, using other
operations.
[0033] The antenna selector 25 may be adjusted to perform a scan of
only the antenna elements from which the strongest signals were
received, excluding all other antennas. Excluding or rejecting
signal information from antennas providing weak signals generally
increases signal to noise ratios.
[0034] However, in another embodiment, location vectors or distance
values may be calculated relating to many antenna elements and
signal vectors having relatively low magnitudes may be multiplied
by a reducing/weighing factor as shown in FIG. 7.
[0035] An estimated location of an in vivo signal source may be
continuously or semi-continuously tracked. An instantaneous
velocity vector for the signal source may be computed using the
position information. For example, the velocity vector would be the
vector starting at the tip of a first location vector and ending at
the tip of a consecutive location vector. Or, the signal source's
speed may be computed as a derivative of its position, and its
direction may be plotted on a display or a graph functionally
associated with the data recorder 20.
[0036] In an embodiment of the invention a supplementary procedure
for detecting defective antenna elements may be carried out. If an
antenna element is determined to be defective the entire trajectory
may be invalidated. In an example of such a procedure readings for
all frames (if not discarded) are collected, for each antenna, into
two bins, for example, Bin1=number of readings in the range 0 to 40
and Bin2=number of readings in the range 41 to 255 or Bin1=number
of readings in the range 0 to 107 and Bin2=number of readings in
the range 108 to 255. The result is 8 histograms of 2 bins each,
one for each antenna. If Bin1/(Bin1+Bin2)>0.75 the antenna is
defective. Else the antenna is OK. The trajectory is considered
valid if all antennas are OK. Further, if thReception(n)<60 (for
the first example) or if thReception(n)<117 (for the second
example) the current sensor readings can be discarded.
[0037] While certain features of the invention have been
illustrated and described herein, many modifications,
substitutions, changes, and equivalents will now occur to those
skilled in the art. It is, therefore, to be understood that the
appended claims are intended to cover all such modifications and
changes as fall within the true spirit of the invention.
* * * * *