U.S. patent application number 11/831588 was filed with the patent office on 2008-01-24 for acupoint patch.
This patent application is currently assigned to 3T HERBTECH, INC.. Invention is credited to Liqin Sun.
Application Number | 20080021421 11/831588 |
Document ID | / |
Family ID | 34272305 |
Filed Date | 2008-01-24 |
United States Patent
Application |
20080021421 |
Kind Code |
A1 |
Sun; Liqin |
January 24, 2008 |
ACUPOINT PATCH
Abstract
A method of applying dermal patches to acupoints in order to
treat medical conditions. The dermal patches can contain extracts
of herbal materials.
Inventors: |
Sun; Liqin; (San Gabriel,
CA) |
Correspondence
Address: |
SHELDON MAK ROSE & ANDERSON PC
100 East Corson Street
Third Floor
PASADENA
CA
91103-3842
US
|
Assignee: |
3T HERBTECH, INC.
1720 S. San Gabriel Blvd Suite 106
San Gabriel
CA
91776
|
Family ID: |
34272305 |
Appl. No.: |
11/831588 |
Filed: |
July 31, 2007 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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10648026 |
Aug 26, 2003 |
|
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11831588 |
Jul 31, 2007 |
|
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60406557 |
Aug 27, 2002 |
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Current U.S.
Class: |
604/307 |
Current CPC
Class: |
A61K 36/484 20130101;
A61P 27/02 20180101; A61F 2013/00446 20130101; A61F 13/023
20130101 |
Class at
Publication: |
604/307 |
International
Class: |
A61F 13/02 20060101
A61F013/02 |
Claims
1. A method of treating an eye of a patient, comprising: (a)
providing a dermal patch comprising one or more medicaments which
promote blood circulation, relax muscles, or regulate nerve
function; and (b) applying the dermal patch to an acupoint of the
eye of the patient, wherein the acupoint is selected from the group
consisting of Sibai, temple, and Zanzhu.
2. The method of claim 1, wherein step (a) further comprises
providing a plurality of dermal patches, and wherein step (b)
further comprises applying a dermal patch to each of the Sibai
acupoint, the temple acupoint, and the Zanzhu acupoint of the eye
of the patient.
3. The method of claim 2, wherein step (b) comprises applying a
dermal patch to each of the Sibai acupoint, the temple acupoint,
and the Zanzhu acupoint of both eyes of the patient.
4. The method of claim 1, wherein the one or more medicaments
promotes blood circulation, relaxes muscles, and regulates nerve
function.
5. The method of claim 1, wherein the medicament comprises a dried,
water-soluble filtrate of an herbal material selected from the
group consisting of Ligusticum wallichii, Salvia miltiorrhiza,
Angelica sinensis, chrysanthemum, tussilago farfara, perillaseed,
tendril-leaved fritillary bulb, fruit of Chinese magnoliavine,
fructus ligustri lucidi, golden cypress, Centipeda minima, magnolia
flower, radix angelicae formosanae, selfheal, radix achyranthis
bidentatae and ramulus uncariae rhynchophyllae.
6. The method of claim 1, wherein the medicament comprises a dried,
water-soluble filtrate of Ligusticum wallichii; a dried,
water-soluble filtrate of Salvia miltiorrhiza; a dried,
water-soluble filtrate of Angelica sinensis; and a dried,
water-soluble filtrate of chrysanthemum,
7. The method of claim 1, wherein the dermal patch is applied to
the patient for a period of time of between 6 hours and 8
hours.
8. The method of claim 1, wherein the dermal patch comprises a
self-stick material and is adhered to the acupoint of the
patient.
9. A method of treating a medical condition of a patient,
comprising: providing a dermal patch comprising one or more
medicaments which promote blood circulation, relax muscles, or
regulate nerve function; and applying the dermal patch to an
acupoint of the patient in order to treat the medical
condition.
10. The method of claim 9, wherein the medicament is a dried,
water-soluble filtrate of an herbal material selected from the
group consisting of Ligusticum wallichii, Salvia miltiorrhiza,
Angelica sinensis, chrysanthemum, tussilago farfara, perillaseed,
tendril-leaved fritillary bulb, fruit of Chinese magnoliavine,
fructus ligustri lucidi, golden cypress, Centipeda minima, magnolia
flower, radix angelicae formosanae, selfheal, radix achyranthis
bidentatae and ramulus uncariae rhynchophyllae.
11. The method of claim 9, wherein the acupoint is Yintang and the
medical condition is selected from the group consisting of
headache, carebaria, forehead pain and insomnia.
12. The method of claim 9, wherein the acupoint is Fengchi and the
medical condition is selected from the group consisting of
headache, insomnia, blurred vision and glaucoma.
13. The method of claim 9, wherein the acupoint is Yifeng and the
medical condition is selected from the group consisting of
tinnitus, deafness and blurred vision.
14. The method of claim 9, wherein the acupoint is Anmian and the
medical condition is selected from the group consisting of
insomnia, dizziness, headache and palpitation.
15. The method of claim 9, wherein the acupoint is Dazhui and the
medical condition is selected from the group consisting of
headache, coughing and panting.
16. The method of claim 9, wherein the acupoint is Dingchuan and
the medical condition is selected from the group consisting of
coughing.
17. The method of claim 9, wherein the acupoint is Jingming and the
medical condition is selected from the group consisting of tearing,
nyctalopia, dizziness, myopia and eye pain.
18. The method of claim 9, wherein the acupoint is Qimen and the
medical condition is selected from the group consisting of liver
pain, abdominal distension, sour regurgitation.
19. The method of claim 9, wherein the acupoint is Riyue and the
medical condition is selected from the group consisting of
choleplania, liver diseases, rib pain and vomiting.
20. The method of claim 9, wherein the acupoint is Zhangmen and the
medical condition is selected from the group consisting of liver
pain, abdominal distention, vomiting, indigestion and diarrhea.
21. The method of claim 9, wherein the acupoint is Zhongwan and the
medical condition is selected from the group consisting of
choleplania, liver pain, stomachache, abdominal distention, reduced
peristalsis, vomiting and insomnia.
22. The method of claim 9, wherein the acupoint is Feiyu and the
medical condition is selected from the group consisting of
coughing, panting, chest pain, night sweats, and hot flashes.
23. The method of claim 9, wherein the acupoint is Ganyu and the
medical condition is selected from the group consisting of
choleplania, rib pain, dizziness and back pain.
24. The method of claim 9, wherein the acupoint is Piyu and the
medical condition is selected from the group consisting of
stomachache, choleplania, abdominal distention, vomiting and
dropsy.
25. The method of claim 9, wherein the acupoint is Shenyu and the
medical condition is selected from the group consisting of
dizziness, asthma, dropsy and lower back pain.
26. The method of claim 9, wherein the acupoint is Tiantu and the
medical condition is selected from the group consisting of asthma,
coughing, sore and swelling throat, aphonia and dry throat.
27. The method of claim 9, wherein the acupoint is Yongquan and the
medical condition is selected from the group consisting of
headache, dizziness, sore throat, dry tongue, hypertension and
constipation.
28. The method of claim 9, wherein the acupoint is Zhongji and the
medical condition is selected from the group consisting of
impotence, frequent micturiction, spermatorrhea, female sexual
coldness, morbid leucorrhoea, and a menstrual disorder.
29. The method of claim 9, wherein the acupoint is Kaiyuan and the
medical condition is selected from the group consisting of
spermatorrhea, enuresis, impotence, dysuria, and menorrhalgia.
30. The method of claim 9, wherein the acupoint is Qugu and the
medical condition is selected from the group consisting of
spermatorrhea, impotence, enuresis, menorrhalgia, and a menstrual
disorder.
31. The method of claim 9, wherein the acupoint is Qihai and the
medical condition is selected from the group consisting of
impotence, hernia, spermatorrhea, diarrhea, amenorrhea and a
menstrual disorder.
32. The method of claim 9, wherein the acupoint is Guilai and the
medical condition is selected from the group consisting of
abdominal pain, impotence, hernia and a menstrual disorder.
33. The method of claim 9, wherein the acupoint is Qichong and the
medical condition is selected from the group consisting of
impotence, vulva swelling, menorrhalgia and a menstrual
disorder.
34. The method of claim 9, wherein the acupoint is Yinxiang and the
medical condition is selected from the group consisting of nasal
congestion, anosmia, nose bleeding, running nose, facial itching
and swelling.
35. The method of claim 9, wherein the acupoint is Renying and the
medical condition is selected from the group consisting of sore
throat, panting, and dizziness.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] The present application is a divisional application which
claims the benefit of priority from U.S. patent application Ser.
No. 10/648,026, filed on Aug. 26, 2003 and titled ACUPOINT PATCH,
which claims the benefit of priority from U.S. Provisional Patent
Application No. 60/406,557, filed on Aug. 27, 2002 and titled
ACUPOINT PATCH. Each of these applications is incorporated herein
by reference in its entirety.
FIELD OF THE INVENTION
[0002] The present invention relates to herbal medicine and more
particularly relates to therapeutic patches which are applied to
various locations of a patient for therapeutic purposes.
BACKGROUND
[0003] For a long time, herbal medicine and herbal treatment in
China have enjoyed seemingly mythical healing powers. As early as
over three thousand years ago, BIAN Que and HUA Tuo, both
prestigious doctors of Chinese medicine, have applied the
fundamental principles of "stimulating blood circulation for
relaxing muscles and joints" to stimulating acupoints on a
patient's body for relaxing and easing purposes.
[0004] As will be described in the present application, the
essences of natural herbs are extracted to make therapeutic patches
of the present invention, based on the principles of Chinese
medicine and acupuncture. When applied to acupoints around the
eyes, the patches of the present invention can achieve an effect
similar to, and yet better than, that of acupuncture. The patches
of the present invention can relax muscles, nerves and blood
vessels around the eyes through painless and easy application. They
also help alleviate eye fatigue and give the patient better
vision.
[0005] Acupoints
[0006] Acupuncture, with a history dating all the way back to
several thousand years in China, is now widely recognized in
western medical field. During recent years, scientists have done
researches as well as anatomic, histochemical, and algesia
physiologic experiments based on contemporary medical knowledge
while continuing the development of acupuncture. Phenomena and the
nature of the main and collateral channels have been studied from
different perspectives. Issues such as the connection between
acupuncture points and feelings, as well as that of acupuncture
points and body organs have been researched to promote the benefits
of combining acupuncture and contemporary medical science. As such,
acupuncture has been a focus of the international medical field. It
is known to all that acupuncture cures diseases by stimulating
specific locations, namely acupoints, of the body. Why is
acupuncture applied to acupoints, instead of other parts of the
body? A brief introduction is as follows.
[0007] The nature of acupoint energy substance is a cytology and
biochemistry issue. Recent research indicates that main and
collateral acupoints are points consisting of cells containing a
relatively large amount of adenosine triphosphate (ATP). Adenosine
is the factory that generates power for the cells. It contains
abundant ATP synthetic enzyme and is capable of producing a large
amount of ATP energy. During experiments, tissue cells taken from
such acupoints such as Zusanli, Hegu and Quchi, as well as from
non-acupoint locations were dyed and observed under microscope.
Comparison indicated that the adenosine inside these cells
increased and showed no deformity. Therefore, we can draw the
conclusion that an increasing amount of good quality adenosine can
produce a large amount of ATP energy and enhance the functions of
different organs and fluid mobility. When acupoints are stimulated
with needles, or other objects such as medicated patches, this
system will produce a large amount of good quality energy to
provide for and to carry different necessary substances and
nutrients.
[0008] The Nobel Prize in Chemistry was awarded, in 1997, to two
scholars for their elucidation of the enzymatic mechanism
underlying the synthesis of adenosine triphosphate (ATP). One of
the researchers who studied cell passage ions had verified the
mechanism of acupuncture. In addition to a large amount of good
quality adenosines, low cell electrical resistance and high current
magnitude, channel and acupoint cells are also featured with good
membrane permeability, more intercellular passages, good cell
viability and complete ATP synthetic enzyme.
[0009] Recent studies of channel and acupoint functions have
provided additional inspirations. Research has indicated that the
concentrations of calcium ions (Ca++) at channels and acupoints are
higher than non-channel or acupoint locations. It has been found
through experiments that stimulating a certain channel with needles
resulted in increase of calcium ion concentrations at other
acupoints on this channel. When any pathological change exists in a
certain organ, the calcium concentrations at surrounding acupoints
experienced abnormal changes, which proved that calcium ion was a
key indicator of channel movements. In addition, Xiao-Song G U, et
al., have recently found that electronic microscope observation of
the differential protein of sensory nerve indicated that 29 KD
protein was only found in the cyton and process of level 1 sensory
neurons. Stimulating acupoints resulted in the secretion of active
substances and enhanced the bridging function of 29 KD protein. The
amount of information passing through the channels increased,
resulting in strong interactive stress and achieving internal
balance. 29 KD protein transmits more than just biological
electrical signals. It can also transmit a variety of ion
substances or small molecule substance. This kind of transmission
is completed through continuous transmission by 29 KD protein. This
is the mechanism underlying the effect of stimulating channels and
acupoints.
[0010] Disadvantages of Acupuncture
[0011] Acupuncture has a history of over three thousand years in
China. Over three thousand years ago, Chinese doctors started to
cure different diseases with acupuncture. Recently, acupuncture has
been widely used to treat eye diseases and ailments. The mechanism
of alleviating and curing eye diseases involves regulating the
channels and the vegetative nervous system. Then observation is on
the artery peripheral plexus and the capillary artery front plexus
formed by adrenalinergic nerves and cholinergic nerves around the
small blood vessels distributed at certain acupoints with
fluorescence organ chemical method. Experimental morphology proved
that they were all fibers of sympathetic ganglions with the
functions of controlling peripheral circulation resistance and
local blood circulation. Using histological method, it was also
observed that the cholesterase small nerve tracts consisting of the
primitive marrow fiber inside the axiom nerve branches penetrated
to deep underneath the acupoints, and extended to close to the
capillary artery along to the small artery and vein before forming
free ends. They then joined the capillary wall nerves and the
vegetative nerves. Therefore, sympathetic nerves are considered an
important part of the channels.
[0012] Acupuncture cures eye diseases by stimulating acupoints
around the eyes and adjusting functions of the vegetative nerves.
Microcirculation is promoted, and so is oxygen and nutrients
transmission around the eye acupoints. Microcirculation stasis is
alleviated, and the ancillary muscles around the eyes are regulated
and relaxed. This results in complete regulation and adjustment of
the eyes. In the meantime, it also helps reduce tension of the
cerebral cortex and thus achieves relaxation, as well as improving
sleep and memory.
[0013] Acupuncture has represented an essential part of traditional
Chinese medicine. Its healing powers and effects have been widely
recognized. We all know that in acupuncture, needles are used to
stimulate acupoints for promoting blood circulation and relaxing
nerves and muscles. Therefore, many ailments, discomforts or
sicknesses can be cured with acupuncture therapy. Many people have
become aware that acupuncture has an advantage in relieving pains
and regulating immunity that is not matched by western medicines.
However, acupuncture has its disadvantages too. First, although
they are aware of the benefits of acupuncture, many people refuse
to accept it as a therapy because of their phobia of pain, namely
from the needles. Unable to overcome the fear of needles, they have
no choice but to avoid acupuncture altogether. To these people,
acupuncture is good, but it would only be perfect if it would not
cause any pain. Second, recent reports have pointed out that
acupuncture is only capable of relaxing local areas and the effects
are temporary too. In acupuncture, the needles stay for 20-30
minutes. In about two hours after treatment is finished, the effect
of acupuncture starts to diminish. One cannot work or sleep while
carrying needles on the body. How to extend the effect of
acupuncture has become a new research subject. As will be described
in the following, the present invention by inventor Liqin SUN can
replace needles. While reducing the pain resulted from treatment,
it also expands the scope of treatment. It is essentially
"acupuncture without needles."
SUMMARY
[0014] A method of using acupoint patches, an apparatus and a
method of making acupoint patches is disclosed. The acupoint patch
of the present invention uses natural herbs as raw materials. It is
made by combining traditional Chinese acupuncture therapy and
contemporary transdermal controlled release technologies. It
originates from acupuncture but easily surpasses acupuncture. As
the essence of traditional Chinese medicine, acupuncture has been
studied and developed during recent years to achieve better effects
and minimum side effects. Acupoint patch application in accordance
with the present invention now reaches beyond what acupuncture
therapy can deliver.
[0015] As will be described herein, the acupoint patch of the
present invention is made with natural herb extracts using
contemporary transdermal absorption technologies based on the
characteristics of different acupoints. They can stay on the skin
for 6-8 hours, during which period natural herb essence enters
blood circulation and performs a sustainable regulating function.
This is a feature unrivaled by traditional acupuncture. As
previously mentioned, acupuncture can only relax ciliary muscles
(effective on pseudomyopia) and only has a temporary effect. The
reason is because in acupuncture, the needles only stay for 20-30
minutes. In about two hours after the treatment finishes, the
effect of acupuncture starts to diminish. The successful experiment
of the acupoint patch of the present invention has overcome the
problem of the temporary effect of acupuncture therapy. It is also
the first painless therapy. Patients only need to apply the
acupoint patch of the present invention to designated acupoints on
the face (Zanzhu, temple, Sibai) before bedtime to achieve the
desired results.
[0016] Also, application of the acupoint patch of the present
invention is easy and safe. It is suitable for patients of
different ages. In addition, the acupoint patch of the present
invention not only has the transdermal absorption feature of
traditional plasters, but also uses controlled release technologies
so that the herbal nutrients enter blood circulation at an even
speed, to ensure consistent blood medicine concentration and to
avoid blood medicine concentration peak/trough problem.
DRAWINGS
[0017] FIG. 1 illustrates the blood medicine concentration (in
ng/ml) vs. application time (in hour).
[0018] FIG. 2 illustrates blood medicine concentration with peak
and trough phenomenon.
[0019] FIG. 3 shows steady blood medicine concentration over time,
where the treatment zone is more stabilized.
[0020] FIG. 4 illustrates a comparison of the acupoint patch of the
present invention and other products in terms of blood medicine
concentration vs. time.
[0021] FIG. 5 illustrates an exemplary flow chart for the herbal
extraction process in accordance with the present invention.
DETAILED DESCRIPTION
[0022] A method, apparatus and method of making medicated patches
is disclosed. In the description that follows, numerous terminology
in herbal medicine, acupuncture and acupoints will be referenced,
using terms familiar to those skilled in the art. Also, the phrase
"acupoint patch" and Applicant's trademark "OCULAX.TM." are used
interchangeably in the present application, as they both refer to
the transdermal acupoint patches for the controlled release of
herbal extracts through the acupoints of a patient's body.
[0023] Disadvantages of Traditional Plasters
[0024] Transdermal medicine has been used in therapies as early as
in the ancient times. Traditional Chinese plasters are some of the
examples. Plasters help overcome the problems of pain and time
limitation of acupuncture. However, the effect of plasters is less
desirable than that of acupuncture, due to their limited
permeability. In addition, although traditional plasters do have
some of the characteristics of transdermal patches, the dosages are
usually not precise. Precise control and maintenance of the desired
blood medicine concentration are difficult to achieve, thus
resulting in unbalanced blood medicine concentration (concentration
peaks and lows). That is to say, during the first two hours after
plasters are applied, the amount of medicine entering blood
circulation is higher than the required amount, whereas after two
hours, the amount of medicine entering blood circulation becomes
insufficient.
[0025] In our experiment, we applied 2% monarkite plasters of the
same size to two patients. Their blood medicine concentrations
differed by several times. This was due to inaccurate plaster
thickness as well as different physiques of the patients. FIG. 1
illustrates the blood medicine concentration (in ng/ml) vs.
application time (in hour).
[0026] OCULAX.TM.--Acupoint Patch of the Present Invention
[0027] The acupoint patch of the present invention, commercially
called OCULAX.TM., uses natural herbs as raw materials. It is made
by combining traditional Chinese acupuncture therapy and
contemporary transdermal controlled release technologies. It
originates from acupuncture but easily surpasses acupuncture. As
the essence of traditional Chinese medicine, acupuncture has been
studied and developed during recent years to achieve better effects
and minimum side effects. Acupoint patch application in accordance
with the present invention now reaches beyond what acupuncture
therapy can deliver.
[0028] As will be described herein, the acupoint patch of the
present invention is made with natural herb extracts using
contemporary transdermal absorption technologies based on the
characteristics of different acupoints. They can stay on the skin
for 6-8 hours, during which period natural herb essence enters
blood circulation and performs a sustainable regulating function.
This is a feature unrivaled by traditional acupuncture. As
previously mentioned, acupuncture can only relax ciliary muscles
(effective on pseudomyopia) and only has a temporary effect. The
reason is because in acupuncture, the needles only stay for 20-30
minutes. In about two hours after the treatment finishes, the
effect of acupuncture starts to diminish. The successful experiment
of the acupoint patch of the present invention has overcome the
problem of the temporary effect of acupuncture therapy. It is also
the first painless therapy. Patients only need to apply the
acupoint patch of the present invention to designated acupoints on
the face (Zanzhu, temple, Sibai) before bedtime to achieve the
desired results.
[0029] Also, application of the acupoint patch of the present
invention is easy and safe. It is suitable for patients of
different ages. In addition, the acupoint patch of the present
invention not only has the transdermal absorption feature of
traditional plasters, but also uses controlled release technologies
so that the herbal nutrients enter blood circulation at an even
speed, to ensure consistent blood medicine concentration and to
avoid blood medicine concentration peak/trough problem.
[0030] Acupoint Patches (OCULAX.TM.) in More Detail
[0031] There have been plenty of conventional healthcare products
directed at preserving vision, relaxing eyes, improving sleeping
patterns, and alleviating eye fatigue. Most of these conventional
products are taken orally. The acupoint patch of the present
invention is made of pure, natural herb extracts by combining
traditional Chinese acupuncture and contemporary transdermal
absorption controlled-release technologies. The acupoint patch in
accordance with the present invention is a product with the
following important implementation features:
[0032] 1. Use of Advanced Technology:
[0033] A. It combines acupoint therapy principles in traditional
Chinese acupuncture;
[0034] B. It uses the state-of-the-art transdermal absorption
controlled release technologies available only in recent years;
[0035] C. It is made of natural herb extracted with
nano-technology;
[0036] D. It is a multi-layer, e.g. five-layer patch.
[0037] 2. Characteristics in Application of Acupoints:
[0038] A. Patch application acupoints include Zanzhu, temple,
Sibai, Fengchi, Jingming, Touwei, Yinxiang, Yingtang, Yifeng and
Anmian;
[0039] B. The acupoint patch is applied to the designated acupoints
before bed time and taken off the following morning. The
application time is 6-8 hours.
[0040] C. The acupoint patch can be applied at any time without
causing any pain.
[0041] 3. Characteristics in Raw Materials Used:
[0042] Raw materials include pure natural herbs such as Tangkuei
(Angelica sinensis), Ligusticum (Ligusticum wallichii),
chrysanthemum, and Salvia root (Salvia miltiorrhiza). These
ingredients have no side effect of whatsoever. Tangkuei,
Ligusticum, chrysanthemum and Salvia root can all promote blood
circulation, regulate nervous system and reduce muscle spasm.
[0043] 4. General Characteristics:
[0044] A. Acupoint patch helps achieve all the benefits of painless
acupoint therapy.
[0045] B. Transdermal absorption controlled-release technology are
used to avoid the blood medicine concentration peak/trough effect
of traditional oral medicines.
[0046] The unique characteristics of the acupoint patch of the
present invention are attributable to the fact that it is the
combination of traditional Chinese acupuncture and modern
technologies. It follows both the principles of traditional Chinese
acupuncture--applying natural herbs at acupoints--and combines
modern transdermal absorption controlled-release technologies. As a
result, Oculax can release effective ingredients at the acupoints
consistently for a relatively longer period of time, and thus,
regulate the nerves, muscles, and blood vessels around the eyes and
in the head to promote eye and head blood circulation and to
achieve the goal of relaxation. It helps in different types of eye
problems, such as dry eyes, eye fatigue, vision deterioration,
photaesthesia and tearing, myopia, presbyopia, glaucoma, and
cataract. It also alleviates migraine, dizziness and insomnia. It
is the textbook example of combining Chinese medicine with western
medicine. OCULAX.TM. has surpassed conventional oral medicines or
eye drops and opened up a new era for eye maintenance products.
[0047] The acupoint patch of the present invention may be made of
natural herbs such as Ligusticum, Tangkuei, Salvia root, and
chrysanthemum. Records in pharmacopoeia, e.g. ZUENG Hu-Zhan et. al,
MODERN STUDY OF TRADITIONAL CHINESE MEDICINE, Vol. 1-6, Xue Yuan
Press, Beijing, China, 1999, ISBN 7-5077-1320-2, indicate that they
have the following functions:
[0048] Ligusticum--Promote blood and Qi circulation. Ligusticum can
remarkably increase brain blood flow and improve mater
microcirculation and flow. It has an evident effect in alleviating
chronic microcirculation disturbance, especially bulbar conjunctiva
microcirculation disturbance.
[0049] Scholars have observed the effect of Ligusticum drops on the
brain blood circulation speed of cerebral arteriosclerosis patients
using a cranial Doppler ultrasound instrument. Twenty-one cerebral
arteriosclerosis patients were given Ligusticum drops. The changes
of their brain blood vessels and brain blood circulation speeds
were observed using cranial Doppler ultrasound blood flow analyzer.
The results indicated that Ligusticum drops could remarkably
improve the vasomotion functions, lower blood viscosity, and
promote brain blood circulation of cerebral arteriosclerosis
patients. This indicates that Ligusticum is a good product for
prevention of cerebral arteriosclerosis.
[0050] Research has also been done using Ligusticum injection to
treat bulbar conjunctiva microcirculation disturbance due to
cerebral thrombus. Ten thrombus patients were given intravenous
injection of 10 ml of 10% Ligusticum. Before injection, bulbar
conjunctiva microcirculation was observed using a regular method.
The results indicated that alleviation of bulbar conjunctiva
microcirculation disturbance was evident after Ligusticum was
injected, mainly reflected in improved flow, faster circulation,
reduced cell concentration or free accumulation. These results were
seen 20 minutes after Ligusticum was injected and was the most
evident in 60 minutes after the injection. In addition, Ligusticum
also has a remarkable effect of dilating blood vessels.
[0051] Salvia Root--Promote blood and Qi circulation, remove blood
stasis and alleviate pain, promote micro blood circulation. It has
a remarkable effect in improving microcirculation, especially eye
bulbar conjunctiva microcirculation.
[0052] Experiments have proven the effect of Salvia root extract on
treating microcirculation disturbance. Salvia root extract can
remarkably dilate the capillaries of rabbits with microcirculation
disturbance. In the experiment, rabbits that had been given
intravenous injections of 10% macromolecule dextrose were given
Salvia root extract. The effect of Salvia root extract on the
capillaries and plasma lactic acid content was observed. The
results indicated that intravenous injection of different dosages
of Salvia root and Salvia root essence could both promote the blood
circulation of rabbits with eye bulbar conjunctiva microcirculation
disturbance and mesenterium microcirculation disturbance. It also
helped in peripheral circulation and thus, alleviated metabolism
problem caused by cell ischemic problem and anoxia.
[0053] Research has also indicated that Salvia root has an
anti-aging function. Scholars have compared the effects of Salvia
root and vitamin E on the SOD and LPO of aged rats. The effects of
Salvia root are better than those of vitamin E. The results
indicated that Salvia root could evidently improve the activity of
the erythrocuprein in the red cells, heart, liver and kidney of
aged rats (P<0.01). Salvia root also remarkably lowered the
content of peroxide fat in the serum, heart, liver and kidney of
the same aged rats (P<0.01). Compared with vitamin E, Salvia
root has better effects.
[0054] Tangkuei--Promote blood and Qi circulation. Major results
include improved flow, faster flow speed and improvement of fundus
blood circulation. Experiments and research has indicated that
Tangkuei is the ideal ingredient to regulate blood vessel
functions. Tangkuei can dilate peripheral blood vessels, lower
blood resistance, and improve blood circulation. Experiments have
shown that Buerger's disease patients experienced improvement of
blood circulation after one month of Tangkuei injection. The
effective rate is 60%.
[0055] Research has proven that the effective ingredient of
Tangkuei is ferulic acid, which can dilate separated major
arteries. Sedated animals were given intravenous injection of 50
mg/kg ferulic acid sodium. Arteria femoralis blood circulation was
increased and external blood vessel resistance was reduced.
Japanese scholars have proven through experiments that in addition
to regulating blood pressure, Tangkuei can also lower eye pressure
and reduce ventricular water production. Therefore, this effect is
considered attributable to both peripheral and central factors.
[0056] Other research has indicated that brewed Tangkuei soup can
remarkably improve learning memory of white rats. The memory of
rats was observed using passive avoidance conditioned
reflex--diving platform experiment. The results indicated that
memories of rats and repeated response abilities of rats were
improved to different degrees.
[0057] Chrysanthemum--Improve vision and refresh, eliminate wind
and clear heat. It can be used to treat red eyes, swelling and
pain, headache and insomnia, and blurred vision and dizziness. It
can dilate blood vessels, increase blood flow and delay the aging
process.
[0058] Experiments have proven that chrysanthemum injection can
dilate blood vessels and increase blood flow. Thoracic sedated cats
were given intravenous injection of 1.5-2.0 g/kg of chrysanthemum.
Coronary venous sinus flow was increased by 93% immediately. During
the 40 minutes of continuous observation, the coronary flow was
increased as compared to that before the injection. In separated
rabbit heart perfusion application, the coronary flow was increased
by 61% and 53% respectively in one minute and three minutes after
application of medicine as compared to that before the application.
Chrysanthemum injection can also remarkably dilate skin and organ
blood vessels. Based on this, chrysanthemum is used in OCULAX.TM.
to improve blood circulation and to increase oxygen and nutrients
supplied to the eyes and the brain blood vessels.
[0059] Research has proven the anti-aging function of
chrysanthemum. Experiments were done to observe the effect of
chrysanthemum immersion liquid on young silkworms. Results
indicated that in addition to extending age, chrysanthemum
immersion liquid could also increase length and weight of silkworms
and promote their development. This proves that chrysanthemum has
an anti-aging function.
[0060] The above natural herbs have no side effects. When applied
at night for 6-8 hours, the natural nutrients can enter blood
circulation through the skin to relax nerves, blood vessels and
muscles around the eyes and to alleviate eye fatigue. They can
promote brain blood circulation, help in sleep and improve
memory.
[0061] While these natural herbs currently come from China and/or
the United States, other sources may be available to those skilled
in the art of extracting herbal essences based on the description
herein. All these materials are pure natural herb extracts, and
their specific information are provided in Tables 1-4 of the
present application.
[0062] Transdermal Controlled-Release Patch
[0063] Technical characteristics of the acupoint patches are as
follows: Due to excessive toxins or ineffective peak/trough
medicine concentration of regulation medication methods (oral
taking, injection, etc.), controlled release technologies have
attracted more and more attention. During the past ten years,
research on controlled medicine release has developed rapidly. A
significant aspect of such research, transdermal treatment system,
has experienced the most radical development and become a new star
using the highest technologies. The acupoint patch of the present
invention is a patch made of natural herbs using transdermal
absorption method. It is directly applied to acupoints around the
eyes and features characteristics not possessed by oral medicines
or eye drops. Preferably, the acupoint patch of the present
invention has five layers with different natures and functions, as
will be described below:
[0064] 1. LINING LAYER: Impermeable to medicines, provide
protection and supporting functions.
[0065] 2. STORAGE LAYER: Medicines are evenly distributed at this
plastic layer.
[0066] 3. CONTROLLED RELEASE LAYER: Serves to control and release
medicines at the required speed.
[0067] 4. PRESSURE SENSITIVE LAYER: Attaching the acupoint patch to
the skin can provide an explosive dosage of medicine so that
medicines can saturate the cuticle quickly and enter into body
blood circulation.
[0068] 5. PROTECTION AND NON-STICKING LAYER: Remove this layer,
before applying the acupoint patch to the patient's
acupoint(s).
[0069] Quality Standards
[0070] The following quality specifications may be adopted for
ensuring the quality of acupoint patches of the present
invention:
[0071] 1. APPEARANCE: The acupoint patch is a round patch with one
side coated with self-adhesive medicine film. Each patch is 2.27
square centimeters.
[0072] 2. DIMENSIONS: Each set consists of six round patches
attached to 4.times.7 centimeter non-sticking plastic protection
film. Each patch is a dark brown patch. Even medicine layer of
consistent color should be observed in any indoor location without
direct sunlight. There should be no detachment of the medicine
layer. The plastic side should be even, clean and free from areas
not covered by medicines.
[0073] 3. INGREDIENTS: The main ingredients of each set of patches
include Ligusticum, Salvia root, Tangkuei and chrysanthemum. Other
materials used include polyacrylic acid medical pressure-sensitive
glue and polyester lining film.
[0074] 4. FUNCTIONALITY: Relax nerves and muscles, refresh,
alleviate fatigue, promote blood and Qi circulation, and distribute
and minimize body heat.
[0075] 5. SPECIFICATION:
[0076] a. Weight variance: Take three sets of patches (total 18
pieces). Remove patches from the adhesive layer. Weigh each piece
with 1/10000 balance and calculate the average weight. Compare the
weight of each piece. The number of patches with a weight variance
over +5% shall not exceed two. No weight variance exceeding +10% is
allowed.
[0077] b. Area of the patch: Take five patches. Measure the
diameter of each round patch and calculate the area. The area of
each set may not be less than 2.2 square centimeters (the sum of
six patches.)
[0078] c. Heat resistance and stability test: Place five patches in
a freezer at -5.degree. and take out in 20 minutes. Touch with
hand. The patches should feel sticky.
[0079] d. Cold resistance and stability test: Place five patches in
a freezer at -5.degree. and take out in 24 hours. Warm up to room
temperature and touch with hand. The acupoint patches should feel
sticky.
[0080] Additional Advantages of Acupoint Patch of the Present
Invention
[0081] The acupoint patches of the present invention can achieve
consistent application of medicines. Medicines released at a
controlled speed enter body circulation consistently and steadily.
This helps avoid peak/trough blood medicine concentrations of other
medicine application methods and gives full play to the curative
and regulating functions of the medicines. Since the medicines do
not pass the digestive tract, destruction of the natural herb
ingredients by pH, food and digestive fluids is avoided. Intestine
or stomach upset, poor absorption and side effects of the
metabolites due to stimulation of the digestive tract are also
avoided. In addition to controlling medicine release, patients may
also apply OCULAX.TM. based on their conditions.
[0082] FIG. 2 shows blood medicine concentration with peak and
trough phenomenon. FIG. 3 shows steady blood medicine concentration
over time, where the treatment zone is more stabilized.
[0083] The acupoint patch of the present invention brings out the
curing effects of short biological half-life medicines that cannot
be easily applied through oral taking or injection, as well as
medicines with narrow "treatment window", while limiting their side
effects.
[0084] Since the medicines do not pass the digestive tract,
destruction of the natural herb ingredients by pH, food and
digestive fluids is avoided. Intestine or stomach upset, poor
absorption and side effects of the metabolites due to stimulation
of the digestive tract are also avoided.
[0085] The preliminary filtering function of the liver is bypassed
to avoid dissolution of medicines by the liver and damage to the
liver caused by medicines.
[0086] The acupoint patch of the present invention is easy to use.
It can be applied or removed based on the patient's need. It is
painless and easily accepted by the patients.
[0087] The acupoint patch can regulate eye nerves, blood vessels
and muscles to restore normal eye operation.
[0088] As can be appreciated, transdermal controlled medicine
release helps achieve predetermined and longer medicine effective
time, and improves medicine's effectiveness. Although the dosage is
relatively small, OCULAX.TM. achieves satisfactory results without
causing any side effects through transdermal absorption at
acupoints. The frequency of medication and total dosage are reduced
whereas the effectiveness is improved. This is the optimal eye care
product.
[0089] Application of the Acupoint Patch
[0090] For treatment and care of the eyes, the patches of the
present invention should be applied to three sets of acupoints
around the eyes every night. The blood vessels, nerves and muscles
passing these three sets of acupoints are introduced as
follows:
[0091] ZANZHU: This acupoint is located at the side above the
eyebrows at the corner of the eye sockets. Distributed at this
acupoint are frontal artery, vein and the medial lateral branches
of facies frontalis.
[0092] TEMPLE: This acupoint is located 0.5 centimeter from the tip
of the brow. Distributed at this acupoint are the temporal branches
of nervus facialis, and orbital arteries and veins.
[0093] SIBAI: This acupoint is below the pupil at the inferior
orbital socket. Distributed at this acupoint are branches of facial
arteries and veins. Orbita arteries and veins are distributed
around nervus facialis and inferior orbital nerves.
[0094] The acupoint patch of the present invention thus helps in
absorption of natural herbal nutrients by using acupoint patch
mechanism. The acupoint patch of the present invention works via
the nerve-incretion-immunity system as follows:
[0095] Patch acupoints.fwdarw.Body.fwdarw.Participation by the
nervous system, the immune system and the immune
system.fwdarw.(feedback).fwdarw.the body forms a new stable
internal environment.
[0096] The acupoint patch of the present invention uses natural
herb extracts as raw materials. It is made based on the mechanism
of acupuncture and contemporary transdermal controlled medicine
release technologies. With the advantages of the acupoints and the
transdermal controlled medicine release, OCULAX.TM. can release
medicines into blood vessels, nerves and muscles around the eyes in
a short time without the pain of acupuncture. It saves time and
improves vision-regulating effectiveness. OCULAX.TM. is truly an
acupuncture therapy without needles.
[0097] OCULAX.TM. application instructions: Apply OCULAX.TM. to the
six designated acupoints (two on Zanzhu, two on the temples and two
on Sibai) every night before sleep. OCULAX.TM. stays for 6-8 hours.
During these 6-8 hours, the natural herb nutrients enter blood
circulation directly through the acupoints at an even speed. The
result is much better than that of 30 minutes of traditional
acupuncture. It also solves the problem of short needle-staying
time.
[0098] The scientific features of the acupoint patches of the
present invention. Based on conventional concepts, people usually
take some nutrients such as vitamin A or comprehensive vitamins to
care for their eyes. Orally taken nutrients are dissolved in the
livers and the kidneys. Most of the nutrients are discharged and
only 10-20% is absorbed. Even less nutrients actually reach the
eyes and the effects are seen slowly. Other people use eye drops as
eye care. However, eye drops only have a temporary relaxing effect
and are therefore, not able to solve the problems. Since eyes are
nerve end organs, regulating acupoints around eyes is the optimal
method to alleviate eye fatigue. From the anatomy point of view,
applying medicines around the eyes brings about the best effects.
OCULAX.TM. patches are applied to acupoints around the eyes.
Medicines enter the blood circulation in the fastest manner to
achieve the goal of regulating. In addition, it is believed in
contemporary medical science that the biological effectiveness of
acupoint patches is better than that of oral medicines because of
the natural herb nutrients sensitivity and amplification effects of
the acupoints. OCULAX.TM. can promote local and general blood
circulation, enhance metabolism, and improve local nutrition, cell
immune and fluid immune functions.
[0099] FIG. 4 illustrates a comparison of OCULAX.TM. and other
products in terms of blood medicine concentration vs. time. Note
that Curve A represents oral medication, Curve B represents
acupuncture, and Curve C represents OCULAX.TM.. From the above
figure we can tell that compared with oral medicines and
acupuncture, OCULAX.TM. has a longer and more stable regulating
function.
[0100] The herbal nutrient content of 6 pieces of OCULAX.TM. is 60
mg, 40% of which enters blood circulation after released through
the skin. This means that approximately 24 mgs work on the eyes.
The effect can last 6-8 hours. Among the 60 mg nutrients of oral
medicines, 25% is absorbed by the body and only 10-20%, e.g. 1.5-3
mg work on the eyes. The effects can last 2-3 hours. The effect of
acupuncture is highly desirable in a short period of time. But the
effects only last for this short period of time. The effective time
is only 15-20% of that of OCULAX.TM..
[0101] Additional Application of Acupoint Patches
[0102] Acupoint patches using transdermal controlled medicine
release present a novel method of treating other ailments and
illness. In addition to caring for the eyes, such acupoint patches
can also be used at other acupoints to treat other illness,
provided that they are applied with the proper herbal extracts. A
more detailed description is as follows:
[0103] Selection of Acupoints:
[0104] Acupoints that can regulate and relax eyes: Zanzhu, temple,
Sibai, Jingming, Fengchi
[0105] Acupoints that can regulate sleep patterns: Anmian, Fengchi,
Yifeng, temple
[0106] Acupoints that can regulate the lungs and the tracheas:
Feiyu, Tiantu, Dingchuan, Shenyu
[0107] Acupoints that can regulate liver metabolism: Qimen, Riyue,
Zhangme, Zhongwan, Ganyu, Piyu
[0108] Acupoints that can alleviate nasal allergy: Yingxiang,
Feiyu, Yintang, Dazhui, Bitong
[0109] Acupoints that can regulate blood pressure: Yintang, Renyin,
Fengehi, Yifeng, Dazhui
[0110] Acupoints that can regulate sexual functions: Qihai,
Kaiyuan, Zhongji, Qugu, Qichong, Guilai
[0111] Acupoints that can treat dementia: Touwei, temple, Fengchi,
Yifeng, Yintang
[0112] Acupoints Selection Method and Related Blood Vessel And
Nerve Distribution
[0113] Yinxiang: Located at the muffle at the same level as the
medial point of the outer edge of ala nasi. Passing this acupoint
include facial artery and vein branches, as well as branches of
nervus facialis and orbital nerves. Regulating this acupoint can
alleviate nasal congestion, anosmia, nose bleeding, running nose,
facial itching and swelling.
[0114] Renying: Next to Adam's apple, located at point A of the
neck and the frontal lip of sternocleidomastoid. Passing this
acupoint include thyroid gland veins and branches of internal and
external carotid arteries. Distributed in the superficial layer are
neck nervus cutaneus, nervus facialis, and deep sympathetic nerves.
Passing the outer side include nervus hypoglossus and nervus vagus.
Regulating this acupoint can alleviate sore throat, panting, and
dizziness.
[0115] Yintang: Located in the middle point between the two brows.
Regulating this acupoint can alleviate headache, carebaria,
forehead pain and insomnia.
[0116] Fengchi: Located at the pit above sternocleidomastoid.
Passing this acupoint include branches of occipital arteries and
veins and branches of occipital nervelets. Regulating this acupoint
can alleviate headache, insomnia, blurred vision and glaucoma.
[0117] Yifeng: Behind the earlobe at the pit between the lower jaw
and the processus mastoideus. Passing this acupoint include ear
arteries and veins, and ear major nerves. At the deeper level is
the nervus facialis node processus mastoideus. Regulating this
acupoint can alleviate tinnitus, deafness and blurred vision.
[0118] Anmian: Located at the middle point between Yifeng and
Fengchi. Regulating this acupoint can alleviate insomnia,
dizziness, headache and palpitation.
[0119] Dazhui: Located below the processus mastoideus of vertebrae
cervicales VII, at the same level as the shoulder. Passing this
acupoint include branches of carotid arteries, the back branches of
cervical nerve VIII, and the median part of the back branches of
thoracic nerve 1. Regulating this acupoint can alleviate headache,
coughing and panting.
[0120] Dingchuan: Located next to Dazhui. Passing these acupoints
are the same nerves and blood vessels as those passing Dazhui.
Regulating this acupoint can cure asthma and alleviate
coughing.
[0121] Jingming: Located at the pit above eye corner. Passing this
acupoint include inner canthus arteries and veins. At the deeper
level are main branches of eye arteries and veins. Passing this
acupoint also include upper and lower trochlea nerves. At the
deeper level are oculomotor nerves and rock nerves. Regulating this
acupoint alleviates tearing, nyctalopia, dizziness, myopia and eye
pain.
[0122] Qimen: Located below the nipple between ribs VI. Passing
this acupoint include intercostal arteries and veins (VI), and
intercostal nerves (VI). Regulating this acupoint can alleviate
liver pain, abdominal distension, sour regurgitation.
[0123] Riyue: Located one rib below Qimen and the nipple between
ribs VII. Passing this acupoint include intercostal arteries and
veins (VII), and intercostal nerves (VII). Regulating this acupoint
can cure choleplania, liver diseases, rib pain and vomiting.
[0124] Zhangmen: Located at the side of abdomen below the tip of
floating rib XI. Passing this acupoint include end of intercostal
arteries (X) and below it is intercostals nerves (X). Regulating
this acupoint can alleviate liver pain, abdominal distention,
vomiting, indigestion and diarrhea.
[0125] Zhongwan: Located on the median of the abdomen, four inches
above the navel. Passing this acupoint include arteria epigastrica
and vena superior, and the front branches of intercostals nerves
(VII). Regulating this acupoint can cure choleplania, liver pain,
stomachache, abdominal distention, reduce peristaltic sound, and
alleviate vomiting and insomnia.
[0126] Feiyu: Located below the processus mastoideus of thoracic
vertebra m, 1.5 inches next to Shenzhu (GV12). Passing acupoint
include the inner back branches of intercostals arteries and veins.
At the deeper level are outer branches. Regulating this acupoint
can reduce coughing, panting, chest pain, night sweat, and hot
flash.
[0127] Ganyu: Located below the crest of thoracic vertebra IX, 1.5
inches next to Jinsuo (GV8). Passing this acupoint include the
inner back branches of intercostals arteries and veins, the inner
back branches of thoracic nerves IX and X. At the deeper level are
the outer branches. Regulating this acupoint can cure choleplania,
rib pain, dizziness and back pain.
[0128] Piyu: Located below the crest of thoracic vertebra XI, 1.5
inches next to Jizhong. Passing this acupoint include the back
branches of intercostal arteries and veins, thoracic nerves XI and
XII, the inner back branches. At the deeper level are the outer
branches. Regulating this acupoint can alleviate stomachache,
choleplania, abdominal distention, vomiting and dropsy.
[0129] Shenyu: Located below the crest of lumbar vertebra, 1.5
inches next to Mingmen. Passing this acupoint include the back
branches of loin arteries and veins (II), and the outer back
branches of loin nerves. At the deeper level are the outer
branches. Regulating this acupoint can alleviate dizziness, asthma,
dropsy and lower back pain.
[0130] Tiantu: Located on the medial point above the sternum.
Passing this acupoint include the branches of subcutaneous arteria
carotis, thyroid arteries. At the deeper level are tracheas. Behind
the manubrium are innominate arteries and aorta. Passing acupoint
also include the front branches of supraclavian nerves. Regulating
this acupoint can reduce asthma, coughing, sore and swelling
throat, aphonia and dry throat.
[0131] Yongquan: Located on the pelma at the pit when toes are
flexed, near the cross point of the front 1/3 and the back 2/3 of
the pelma. Passing this acupoint include deeper arcus plantaris and
musculus nerves. Regulating this acupoint can alleviate headache,
dizziness, sore throat, dry tongue, hypertension and
constipation.
[0132] Zhongji: Located on the median of the abdomen, four inches
below the navel. Passing this acupoint include branches of
superficial napes arteries and veins, the branches of arteria
epigastrica and vena inferior, and branches of femoris hypogastric
nerves. Regulating this acupoint can cure impotence, frequent
micturiction, spermatorrhea, female sexual coldness, morbid
leucorrhoea, and menstrual disorder.
[0133] Kaiyuan: Located on the median of the abdomen, three inches
below the navel. Blood vessels passing this acupoint are the same
as those passing Zhong Ji. Passing acupoint include the front inner
branches of intercostal nerves XII. Regulating this acupoint can
cure spermatorrhea, enuresis, impotence, difficult urination, and
menorrhalgia.
[0134] Qugu: Located at the middle point of the upper edge of
symphysis pubis. Passing this acupoint include branches of arteria
epigastrica inferior, obturator arteries, and branches of femoris
hypogastric nerves. Regulating this acupoint can cure
spermatorrhea, impotence, enuresis, menorrhalgia, and menstrual
disorder.
[0135] Qihai: Located on the median of the abdomen, 1.5 inches
below the navel. The blood vessels and nerves passing this acupoint
are the same as those passing Shimen. Regulating this acupoint can
cure impotence, hernia, spermatorrhea, diarrhea, amenorrhea and
menstrual disorder.
[0136] Guilai: Located at four inches below the navel and two
inches next to Zhongji. Passing this acupoint include arteria
epigastrica and vena inferior as well as femoris hypogastric
nerves. Regulating this acupoint can alleviate abdominal pain, and
cure impotence, hernia and menstrual disorder.
[0137] Qichong: Located at five inches below the navel and two
inches next to Qugu. Passing this acupoint include superficial
branches of napes arteries and veins and at the outer side are
arteria epigastrica and vena. Passing this acupoint are also iliac
nerves. Regulating this acupoint can cure impotence, vulva
swelling, menorrhalgia and menstrual disorder.
Applying the Patches
[0138] The manufacture methods of these patches are the same as
that of OCULAX.TM.. They are also made of natural herb extracts by
combining acupuncture and transdermal controlled release
technologies. Chinese herbs used include tussilago farfara,
perillaseed, tendril-leaved fritillary bulb, fruit of Chinese
magnoliavine, fructus ligustri lucidi, golden cypress, Centipeda
minima, magnolia flower, radix angelicae formosanae, selfheal,
radix achyranthis bidentatae and ramulus uncariae
rhynchophyllae.
[0139] The patches are to designated acupoints based on their
different functions, using the same application method.
[0140] Application time is 6-8 hours. The patients may choose to
apply at day time or night based on different functions.
[0141] The application methods are basically the same as the
application methods for OCULAX.TM.. Minor adjustments may be
necessary for different diseases and acupoints, as can be
appreciated by those skilled in the art.
[0142] Using the Acupoint Patch
[0143] The following is an exemplary procedure intended to teach a
patient about using the acupoint patches. First, the patient is to
wash face and apply to Zanzhu, temple and Sibai, before bed time.
For dry skin, the patient should apply skincare product before
application of acupoint patches. After getting up the following
morning, the patient can remove the patches. The patient applies
continuously for ten days, stop for 3-5 days and then continue.
[0144] Manufacturing Process
[0145] The acupoint patches are generally prepared as follows:
[0146] 1. Preparation of Chinese herbs: Extract essence of
Ligusticum, Salvia root, Tangkuei and chrysanthemum, dry, grind and
screen.
[0147] 2. Preparation of polyvinyl materials: Process medical flesh
color PVC with special physical method. Make self-stick materials
with PET.
[0148] 3. Preparation of polyester film: Coat both side of
polyester film (0.09.about.0.15 mm thick) with medical organic
silicon anti-sticking materials. The coating should be even and of
an appropriate thickness.
[0149] 4. Preparation of patches: Pour extracts of Ligusticum,
Salvia root, Tangkuei and chrysanthemum mixed at the prescribed
ratio into medical pressure-sensitive polyacrylic acid latex. Mix
even and place in a coating machine for coating. Use PVC film as
the base material and polyester film as the lining material. Dry in
an oven. Cut into patches with a diameter of 17 mm. Inspect and
pack to make finished products.
[0150] There are two types of controlled release technologies, the
application of which depends on the specific use of those skilled
in the art.
[0151] 1. Mix nitrogen ketone with the prepared herbs and
pressure-sensitive latex. Place in a coating machine for coating.
This is called transdermal absorption controlled release
technology.
[0152] 2. Coat the PVC material with herbs and put a controlled
release film in the medicine layer to slow down the release
process. It should be noted that different controlled release
methods can be achieved based on different applications.
[0153] Exemplary Ingredients of Acupoint Patches
[0154] 1. An exemplary ratio of the main ingredients is: Ligusticum
19 mg, Salvia Root 17 mg, Tangkuei 11 mg, Chrysanthemum 33 mg.
[0155] 2. Other herbs can be added as the ingredients besides
Ligusticum, Salvia Root, Tangkuei and Chrysanthemum. This depends
on the different types of eye ailments or diseases. The auxiliary
ingredients are Polyacrylic adhesives and Azoo.
[0156] Exemplary Manufacturing Process of OCULAX.TM.
[0157] 1. Process of herb extraction: Extract the valid composition
from Ligusticum, Salvia Root, Tangkuei and Chrysanthemum.
Concentrate and dry the extracts and make them into small powder
for later use. The flowchart of the herb extraction process is
shown in FIG. 5. This process involves extracting water-soluble
components from the herbal ingredients, filtering the water-soluble
fraction (filtrate) from the solid herbal components, and drying
the filtrate to produce a dried, water-soluble filtrate of each of
the herbal materials.
[0158] 2. Process of Polyester thin plastics: First iron the
definite-thickness polyester thin plastics by electricity. Second,
evenly apply the organic-silicon paste-proofing agent on the
polyester thin plastics. Stove the polyester thin plastics for
later use.
[0159] 3. Process of the silk: First, process a special
waterproofing on weaved silk. Then plate Aluminum on the silk for
later use.
[0160] 4. Process of the herbs mixture: Weigh certain amount of
polyacrylate emulsion. While agitating the polyacrylate, add
quantify extracts of Ligusticum, Salvia Root, Tangkuei and
Chrysanthemum one by one. 60 minutes later, add some trans-derma
promoter, wetness retainer and fragrance. Then agitate for 30
minutes. Test the PH value of the solution till the PH value
showing at the middle value. At last, filter the solution for later
use.
[0161] The Manufacturing Process of OCULAX:
[0162] A. Herbs Control:
[0163] Evenly apply the processed solution on the processed silk by
scraping or transfer. Control the quantity of the colloidal
substance on the processed silk to no lower than 120 g/square
meter. Cover the processed polyester thin plastics and cut it into
round standard of 17 mm diameter. After Quality Control inspection,
pack it into finished products. The structure is as the
follows:
[0164] 1. Silk Lining
[0165] 2. Herbs Storage Layer
[0166] 3. Protection Layer
[0167] According to this manufacturing process, the release of
herbal extracts is controlled by the transdermal promoter and
measurements of nano-processed particles. It also controls the
density of the blood medicine so that it can control the pace of
the treatment.
[0168] B. Controlled Releasing:
[0169] First dissolve the herb extracts. Add by evenly applying the
processed solution on the processed silk by scraping or transfer.
Paste the release control film on the herbs storage layer and
evenly apply the sensitivity reduction layer on the release control
film layer. Cut it into appropriate standard pieces and cover the
processed protection layer. Pack it into completed products. The
structure is as the follows:
[0170] 1. Silk Lining
[0171] 2. Herb Storage Layer
[0172] 3. Release Control Layer
[0173] 4. Sensitivity Reduction Layer
[0174] 5. Protection Layer
[0175] The following tables include further information regarding
ingredients used to make OCULAX.TM. patches. TABLE-US-00001 TABLE 1
Product: Ligusticum Appearance: Brown Dosage Form: Powder
Determination Result Specifications Solvent Total Ash 3.95%
<10.00% Content: Acid-Insoluble 1.86% <2.0% 10% HCL Ashes:
Loss on 3.96% <12.00% Drying: H20 Extract: 52.62% >27.00% H20
Dil. Eton 35.17% >26.00% 50% Eton Extract: Heavy Metal: Ok Not
more than 1000/g E. coli: Negative Salmonella: Negative Bacter
Total: Ok Not more than 1000/g Identification: Positive Purity:
Positive TLC Test: Ligusticum Wallichii Posibive
[0176] TABLE-US-00002 TABLE 2 Product: Salvia Root Appearance:
Brown Dosage Form: Powder Determination Result Specifications
Solvent Total Ash 3.28% <8.00% Content: Acid-Insoluble 1.71%
<4.00% 10% HCL Ashes: Loss on 4.41% <7.00% Drying: H20
Extract: 44.06% >44.00% H20 Dil. EtOH 36.82% >38.00% 50% EtOH
Extract: Heavy Metal: Ok Not more than 100 ppm E. coli: Negative
Salmonella: Negative Bacter Total: Ok Not more than 1000/g
Identification: Positive Purity: Positive TLC Test: Salvia
miltiorrhiza Positive
[0177] TABLE-US-00003 TABLE 3 Product: Tangkuei Appearance: Brown
Dosage Form: Powder Determination Result Specifications Solvent
Total Ash 4.05% <0.00% Content: Acid-Insoluble 2.01% <2.00%
10% HCL Ashes: Loss on 0.87% <7.00% Drying: H20 Extract: 47.89%
>45.00% H20 Dil. EtOH 40.72% >40.00% 50% EtOH Extract: Heavy
Metal: Ok Not more than 100 ppm E. coli: Negative Salmonella:
Negative Bacter Total: Ok Not more than 1000/g Identification:
Positive Purity: Positive TLC Test: Angelica sinensis Positive
[0178] TABLE-US-00004 TABLE 4 Product: Chrysanthemum Appearance:
Brown Dosage Form: Powder Determination Result Specifications
Solvent Total Ash 3.66% <12.00% Content: Acid-Insoluble 2.80%
<3.00% 10% HCL Ashes: Loss on 4.93% <10.00% Drying: H20
Extract: 55.30% >24.00% H20 Dil. EtOH 38.97% >25.00% 50% EtOH
Extract: Heavy Metal: Ok Not more than 100 ppm E. coli: Negative
Salmonella: Negative Bacter Total: Ok Not more than 1000/g
Identification: Positive Purity: Positive TLC Test: Chrysanthemum
Norifolium Positive
[0179] Although only a few exemplary embodiments of this invention
have been described in detail above, those skilled in the art will
readily appreciate that many modifications are possible in the
exemplary embodiments without materially departing from the novel
teachings and advantages of this invention. Accordingly, all such
modifications are intended to be included within the scope of this
invention as defined in the following claims.
* * * * *