U.S. patent application number 11/772057 was filed with the patent office on 2007-12-13 for processes for detecting toxic substances.
This patent application is currently assigned to DAIKIN INDUSTRIES, LTD.. Invention is credited to Hitoshi IWAHASHI, Emiko Kitagawa, Yuko Momose, Junko Takahashi.
Application Number | 20070287155 11/772057 |
Document ID | / |
Family ID | 19083356 |
Filed Date | 2007-12-13 |
United States Patent
Application |
20070287155 |
Kind Code |
A1 |
IWAHASHI; Hitoshi ; et
al. |
December 13, 2007 |
PROCESSES FOR DETECTING TOXIC SUBSTANCES
Abstract
Biology-based processes for detecting toxic substances are
provided. The processes comprise detecting mRNA that is expressed
in the presence of toxic substances by a cell comprising a yeast
gene as followed, or a gene that is homologous to the yeast genes
and is derived from other species, wherein the mRNA corresponds to
said yeast gene or said homologous gene thereof.
Inventors: |
IWAHASHI; Hitoshi;
(Tsukuba-Shi, JP) ; Momose; Yuko; (Tsukuba-Shi,
JP) ; Kitagawa; Emiko; (Tsukuba-Shi, JP) ;
Takahashi; Junko; (Tsukuba-Shi, JP) |
Correspondence
Address: |
BIRCH STEWART KOLASCH & BIRCH
PO BOX 747
FALLS CHURCH
VA
22040-0747
US
|
Assignee: |
DAIKIN INDUSTRIES, LTD.
Osaka-shi
JP
|
Family ID: |
19083356 |
Appl. No.: |
11/772057 |
Filed: |
June 29, 2007 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
10487439 |
May 27, 2004 |
|
|
|
PCT/JP02/08494 |
Aug 23, 2002 |
|
|
|
11772057 |
Jun 29, 2007 |
|
|
|
Current U.S.
Class: |
435/6.13 |
Current CPC
Class: |
C12Q 2600/158 20130101;
C12Q 1/6876 20130101 |
Class at
Publication: |
435/006 |
International
Class: |
C12Q 1/68 20060101
C12Q001/68 |
Foreign Application Data
Date |
Code |
Application Number |
Aug 24, 2001 |
JP |
2001-255380 |
Claims
1. A process for detecting NA.sub.2As, which comprises detecting an
increase in mRNA, wherein the increase in mRNA is 2 or more when
the level of expressed mRNA in the presence of NA.sub.2As is
divided by the level of expressed mRNA in the absence of
NA.sub.2As, by a cell comprising a yeast gene that is selected from
the group consisting of the following, or a gene that is homologous
to the yeast genes and is derived from other species, wherein the
mRNA corresponds to said yeast gene or said homologous gene
thereof, YBR072W, YFLO14W, YLLOGOC, YCL035C, YNL160W, YHR030C,
YCRO21C, YDR513W, YKL161C, YPL223C, YER042W, YCR1O2C, YDL218W,
YDR533C, YKLO71W, YLR460C, YMR090W, YOL150C, YBLO48W, YGL121C,
YHR02.9C, YHR209W, YKL107W, YLLO56C, YLR297W, YOR391C, YLR346C,
YOR049C, YBLO49W, YDR070C, YER037W, YGR142W, YGR16IC, YMR04OW,
YMR322C, YNL134C, YOR152C, YHR138C, YJL171C, YLRO54C, YMR009W,
YMR107W, YMR316W, YOL162W, YORO19W, YPR151C, YLR194C, YIL117C,
YOR248W, YPLO54W, YBR147W, YDROO3W, YERO67W, YILO58W, YLR108C,
YDR132C, YEL072W, YKR071C, YOR255W, YBR047W, YGL117W, YLL062C,
YLR364W, YAL018C, YAR064W, YBR012C, YNL058C, YDR281C, YCROO7C,
YOL118C, YOR38SW, YGRO08C, YLR142W, YBR291C, YLR038C, YDR178W,
YJL166W, YFLO14W, YGR18OC, YGR18OC, YJLO26W, YDL059C, YGR180C,
YGLO91C, YCR107W, YDL243C, YFLO56C, YFLO57C, YJR155W, YNL331C,
YOL165C, YPL171C, YDL021W, YGRO43C, YHR179W, YPLO88W, YGR008C,
YMR105C, YEL011W, YBR299W, YCR105W, YGL191W, YLR038C, YDR178W,
YJL166W, YER008C, YER296C, YER294W, YGL006W, YGRO55W, YOL119C,
YHR092C, YFLO55W, YLL055W, YHL036W, YHRO48W, YLR092W, YML116W,
YBR291C, YPR201W, YAL067C, YLL061W, YDR342C, YPR194C, YCR107W,
YDL243C, YFLO14W, YFL056C, YFLO57C, YJR155W, YNL331C, YOL165C,
YPR167C, YER256C, YER296C, YDL021W, YGR043C, YJR010W, YKL001C,
YLR303W, YOL151W, YPLO88W, YDL124W, YBR294W, YDR368W, YER091C,
YGL184:C, YIR017C, YKL218C, YML131W, YGRO55W, YJR137C, YIL167W,
YDR487C, YELO11W, YHR092C, YLR142W, YER050C, YER093C, YFL055W,
YDL168W, YDR253C, YDR513W, YFRO30W, YHLO36W, YJL155C, YLR092W,
YMR081C, YNL277W, YBR291C, YIL168W, YKR061W, YAL067C, YER042W,
YKR069W, YLL061W, YLRO99C, YCR105W, YDR043C, YGR180C, YJL026W,
YDR342C, YDR178W, YLL060C, YBLO64C, YER008C, YCL035C, YHR055C,
YER185W, YHRO53C, YKL026C, YDL168W, YDR513W, YHR048W, YJL101C,
YML116W, YLL057C, YPR2000, Y0R031W, YKR076W, YHR139C, YGR213C,
YEL078C, YNL036W, YOR134W, YDL020C, YLR327C, YNL093W, YEL066W,
YJR122W, YNL015W, YBR182C, YGR067C, YER184C, YOR058C, YER076W,
YFRO14C, YHR136C, YOR327C, and YOL109W.
2. The process according to claim 1, wherein the yeast gene belongs
to a category of unknown yeast genes.
3. The process according to claim 1, wherein the yeast gene belongs
to a category of mitochondria genes.
4. The process according to claim 1, wherein the yeast gene belongs
to a category of DNA repair genes.
5. The process according to claim 1, wherein the yeast gene belongs
to a category of energy genes.
6. The process according to claim 1, wherein the yeast gene belongs
to a category of transport facilitation genes.
7. The process according to claim 1, wherein the yeast gene belongs
to a category of stress protein genes.
8. The process according to claim 1, wherein the yeast gene belongs
to a category of metabolism genes.
9. The process according to claim 1, wherein the yeast gene belongs
to a category of detoxification genes.
10. The process according to claim 1, wherein the mRNA is amplified
by reverse transcription-PCR, and then detected.
11. The process according to claim 10, which comprises: adding a
test material to the cell, and incubating the mixture; extracting
mRNA from the cell; preparing cDNA from the mRNA via reverse
transcription using labeled nucleotides; and hybridizing the cDNA
as used as probe with the gene as defined in claim 1.
12. The process according to claim 11, wherein step (4) as defined
in claim 11 is conducted on a microarray containing the gene as
defined in claim 1.
13. The process according to claim 1, wherein the mRNA is detected
by northern blotting.
14. The process according to claim 13, which comprises: adding a
test material to the cell, and incubating the mixture; extracting
mRNA from the cell; and hybridizing the mRNA with the gene as
defined in claim 1.
15. The process according to claim 14, wherein step (3) as defined
in claim 14 is conducted on a microarray containing the gene as
defined in claim 1.
16. The process according to claim 1, wherein the detection of mRNA
is conducted by detecting the production of a polypeptide encoded
by the gene as defined in claim 1.
Description
FILED OF THE INVENTION
[0001] This invention relates to biology-based processes for
detecting toxic substances, and specifically to processes for
detecting toxic substances which comprises detecting mRNA that is
transcribed in the presence of test materials by a particular gene
from yeast.
BACKGROUND ART
[0002] Environmental chemical fate search has been conducted every
year for 24 years from 1974 through 1998 by Environment Agency, and
revealed that about 40% of 775 chemical substances that have been
searched so far are emitted into the environment. Chemical
substances that are industrially produced at the present in Japan
are estimated about 50,000, and the production scale and the kinds
of chemical substances are increasing year by year. It is known
that chemical substances that are accidentally produced by water
treatment with chlorine and incineration pollute the environment.
Although such facts allow us to predict that there are a large
number of chemical substances that have been accumulated in the
environment, it is extremely difficult to search and examine
individually the all chemical substances.
[0003] Conventional bioassays (approaches to evaluate the harmful
effects on biological materials on the basis of their responses)
wherein inhibited growth and particular biological responses in
individuals and cells of fishes, daphnia and shellfish are used as
indicators make it possible to determine the presence or absence of
the toxicity of chemical substances in the environment, but neither
possible to evaluate the characters nor origins of the toxicity.
The evaluation methods based on the activity of nitrite-forming
bacteria or nitrate-forming bacteria (Japanese Patent Publication
(kokai) No. 123705/1994, Japanese Patent Publication (kokai) No.
2000-206087) and the activity of iron bacteria have been proposed,
and devices such as Acute toxiciants monitor (Fuji Electric
Corporate Research and Development, Ltd. Japan) are marketed in
Japan. In foreign countries, the devices for evaluation based on
emission intensity of luminous bacteria are commercially available
(MICROTOX, azur, Co., USA; LUMIS, drlange, Co. Germany). However,
those devices still involve conventional bioassays, and never
provide any detailed information of toxic chemical substances.
[0004] In Japan, the risk control of chemical substances is
reconsidered every time a chemical substance pollution is newly
found, and official regulations and self-imposed regulations are
combined to organize the system for risk control. However, any
system has not been yet organized that could quickly respond to the
present complicated and diversified conditions including accidental
productions and environmental emission of toxic chemical substance
as typified by trihalomethane and dioxin. Animal experiments as
used in the method for evaluation of toxic substance of "Law
Concerning Examination and Manufacture, etc. of Chemical
Substances" are expensive and time-consuming, and are not accepted
across the world. Although, as such, the control system has been
continuously discussed, it has not been successfully accomplished
because there is no way to dissolve the problem. Thus, a method for
detect readily chemical substances occurring in the environment is
desired.
DISCLOSURE OF THE INVENTION
[0005] The inventors of the present application found that a toxic
substance induces the expression of mRNA from particular yeast
genes, and accomplished the present invention.
[0006] Specifically, the invention of the present application
relates a process for detecting a toxic substance, which comprises
detecting mRNA that is expressed in the presence of a test material
by a cell comprising a yeast gene that is selected from a group
consisting of the following, or a gene that is homologous to the
yeast genes and is derived from other species, wherein the mRNA
corresponds to said yeast gene or said homologous gene thereof:
YBR072W, YCR102C, YCR107W, YDL218W, YDL243C, YDR453C, YDR533C,
YFL014W, YFL056C, YFL057C, YGR110W, YJR155W, YKL071W, YKR076W,
YLL060C, YLR460C, YMR090W, YNL331C, YNL332W, YNL335W, YOL150C,
YOL165C, YPL171C, YPR167C, YBL048W, YBL064C, YBL107C, YBR008C,
YBR173C, YBR256C, YBR296C, YDL021W, YFL022C, YFL024C, YFL061W,
YGL121C, YGL158W, YGR043C, YHR029C, YHR112C, YHR139C, YHR179W,
YHR209W, YIR030C, YJR010W, YJR048W, YKL001C, YKL107W, YKR075C,
YKR097W, YLL056C, YLR297W, YLR303W, YML087C, YMR096W, YNL274C,
YOL151W, YOR226C, YOR338W, YOR391C, YPL280W, YDR406W, YJL153C,
YLR346C, YOR049C, YOR153W, YPL088W, YAL034C, YDL124W, YDL174C,
YDR476C, YGL156W, YGR035C, YGR157W, YGR213C, YGR281W, YGR284C,
YHL047C, YHR043C, YHR044C, YHR054C, YJR073C, YKL165C, YLR008C,
YMR315W, YNL211C, YOL031C, YOL101C, YOR303W, YAL005C, YAR031W,
YBL005W-A, YBL022C, YBL041W, YBL049W, YBL075C, YBL078C, YBR062C,
YBR169C, YBR294W, YCL020W, YCL035C, YCL043C, YCL050C, YCL057W,
YCR012W, YCR013C, YCR060W, YDL007W, YDL027C, YDL097C, YDL110C,
YDL126C, YDL169C, YDR070C, YDR155C, YDR158W, YDR204W, YDR210W,
YDR214W, YDR258C, YDR313C, YDR368W, YDR435C, YER012W, YER037W,
YER091C, YER103W, YFL044C, YFR003C, YFR010W, YFR020W, YFR024C,
YFR044C, YFR053C, YGL006W, YGL048C, YGL062W, YGL141W, YGL157W,
YGL163C, YGL180W, YGL184C, YGR010W, YGR028W, YGR032W, YGR048W,
YGR124W, YGR135W, YGR142W, YGR161C, YGR192C, YGR197C, YGR201C,
YGR212W, YGR231C, YGR244C, YGR254W, YGR268C, YHL030W, YHR016C,
YHR018C, YHR055C, YHR087W, YHR166C, YIL160C, YIR017C, YJL034W,
YJL048C, YJL052W, YJL144W, YJL163C, YJR009C, YJR069C, YJR074W,
YJR130C, YJR149W, YKL065C, YKL073W, YKL103C, YKL142W, YKL210W,
YKL218C, YKR011C, YKR018C, YKR046C, YKR049C, YLL024C, YLL026W,
YLR027C, YLR080W, YLR107W, YLR121C, YLR132C, YLR133W, YLR155C,
YLR158C, YLR161W, YLR195C, YLR217W, YLR328W, YLR336C, YLR345W,
YLR370C, YLR423C, YML004C, YML092C, YML128C, YML130C, YML131W,
YMR040W, YMR118C, YMR214W, YMR251W, YMR297W, YMR322C, YNL036W,
YNL055C, YNL071W, YNL094W, YNL134C, YNL155W, YNL160W, YNL239W,
YNL241C, YOL005C, YOR020C, YOR027W, YOR037W, YOR059C, YOR120W,
YOR134W, YOR152C, YOR173W, YOR289W, YOR362C, YPL240C, YPR030W,
YAL008W, YAL023C, YAL060W, YAL062W, YAR009C, YBL101C, YBR006W,
YBR046C, YBR052C, YBR053C, YBR056W, YBR099C, YBR137W, YBR139W,
YBR149W, YBR170C, YBR177C, YBR203W, YBR207W, YBR212W, YBR239C,
YBR284W, YBR293W, YCL018W, YCL033C, YCL040W, YCL049C, YCR062W,
YCR067C, YCR082W, YDL010W, YDL020C, YDL024C, YDL054C, YDL095W,
YDL100C, YDL115C, YDL144C, YDL198C, YDL223C, YDL245C, YDL246C,
YDR001C, YDR032C, YDR058C, YDR072C, YDR127W, YDR168W, YDR169C,
YDR188W, YDR231C, YDR261C, YDR264C, YDR272W, YDR293C, YDR304C,
YDR330W, YDR403W, YDR411C, YDR427W, YDR436W, YDR497C, YDR511W,
YDR516C, YDR519W, YDR545W, YEL012W, YEL030W, YER004W, YER009W,
YER021W, YER035W, YER053C, YER079W, YER094C, YER096W, YER125W,
YER158C, YER163C, YER175C, YER177W, YER178W, YER185W, YFL006W,
YFL010C, YFL016C, YFL029C, YFL030W, YFL031W, YFL032W, YFL038C,
YFL041W, YFR004W, YFR047C, YFR050C, YFR052W, YGL011C, YGL013C,
YGL037C, YGL047W, YGL053W, YGL091C, YGL094C, YGL127C, YGL150C,
YGL199C, YGL207W, YGL248W, YGR008C, YGR037C, YGR055W, YGR101W,
YGR130C, YGR154C, YGR194C, YGR221C, YGR232W, YGR248W, YGR253C,
YGR256W, YHL008C, YHR027C, YHR053C, YHR057C, YHR111W, YHR138C,
YHR161C, YHR164C, YHR169W, YHR174W, YHR176W, YHR199C, YIL010W,
YIL034C, YIL041W, YIL045W, YIL087C, YIL107C, YIL142W, YIL155C,
YIR034C, YIR036C, YIR037W, YIR038C, YIR039C, YJL001W, YJL031C,
YJL035C, YJL053W, YJL057C, YJL066C, YJL068C, YJL082W, YJL099W,
YJL102W, YJL151C, YJL152W, YJL161W, YJL164C, YJL171C, YJL172W,
YJL210W, YJL219W, YJR008W, YJR045C, YJR046W, YJR106W, YJR117W,
YJR137C, YKL007W, YKL026C, YKL035W, YKL091C, YKL104C, YKL117W,
YKL145W, YKL146W, YKL151C, YKL152C, YKL153W, YKL193C, YKL195W,
YKL213C, YKL215C, YLL028W, YLL039C, YLL058W, YLR054C, YLR103C,
YLR120C, YLR136C, YLR149C, YLR152C, YLR178C, YLR259C, YLR299W,
YLR324W, YLR327C, YLR348C, YLR350W, YLR356W, YLR362W, YLR387C,
YLR429W, YML054C, YML070W, YML100W, YML117W, YML125C, YMR004W,
YMR008C, YMR009W, YMR020W, YMR067C, YMR089C, YMR097C, YMR102C,
YMR105C, YMR107W, YMR152W, YMR180C, YMR184W, YMR191W, YMR219W,
YMR271C, YMR275C, YMR295C, YMR314W, YMR316W, YNL006W, YNL007C,
YNL012W, YNL044W, YNL045W, YNL074C, YNL092W, YNL093W, YNL104C,
YNL115C, YNL156C, YNL231C, YNL234W, YNL237W, YNL281W, YNL305C,
YNL333W, YNR010W, YNR019W, YNR033W, YNR059W, YNR068C, YNR069C,
YOL032W, YOL036W, YOL047C, YOL071W, YOL082W, YOL083W, YOL117W,
YOL119C, YOL126C, YOL131W, YOL153C, YOL162W, YOL163W, YOL164W,
YOR019W, YOR035C, YOR036W, YOR099W, YOR117W, YOR124C, YOR130C,
YOR132W, YOR157C, YOR185C, YOR197W, YOR259C, YOR261C, YOR273C,
YOR288C, YOR332W, YOR336W, YOR347C, YPL017C, YPL087W, YPL106C,
YPL109C, YPL149W, YPL154C, YPL196W, YPL206C, YPL222W, YPR023C,
YPR024W, YPR026W, YPR067W, YPR103W, YPR108W, YPR151C, YAL012W,
YBR029C, YBR222C, YCL009C, YCL027W, YCL064C, YCR098C, YDL222C,
YDR055W, YDR077W, YDR502C, YEL001C, YEL042W, YER026C, YER106W,
YGR136W, YGR138C, YHR137W, YHR142W, YIL023C, YIL153W, YJL073W,
YJR004C, YJR054W, YKL039W, YKL086W, YKL163W, YKR091W, YLR109W,
YLR194C, YLR250W, YMR095C, YMR189W, YNL106C, YNL169C, YNL322C,
YOR181W, YOR198C, YOR208W, YOR247W, YPL089C, YAL038W, YAL053W,
YBR023C, YBR214W, YBR295W, YCR048W, YDL072C, YDL204W, YDR085C,
YDR098C, YDR259C, YDR380W, YDR388W, YDR391C, YDR432W, YDR481C,
YDR510W, YER069W, YGL022W, YGL126W, YGL209W, YGL255W, YGR189C,
YGR282C, YHL035C, YHR030C, YIL022W, YIL024C, YIL117C, YIL123W,
YIL140W, YIL154C, YJL088W, YJL108C, YJL149W, YJL159W, YJL186W,
YJR148W, YKL096W, YLR180W, YLR273C, YLR300W, YLR307W, YLR378C,
YLR391W, YMR094W, YMR104C, YMR276W, YMR296C, YNL190W, YNL208W,
YNL300W, YNR064C, YOL013C, YOL058W, YOR248W, YOR355W, YPL052W,
YPL163C, YPR079W, YAR028W, YBR146W, YBR183W, YCL038C, YCR071C,
YDL008W, YDR019C, YDR031W, YDR115W, YDR486C, YER038C, YER130C,
YFL054C, YGL136C, YGR146C, YGR207C, YHL040C, YIL167W, YJL020C,
YKR039W, YLR031W, YLR205C, YMR072W, YMR140W, YMR173W, YMR195W,
YMR226C, YNL037C, YNR002C, YOL143C, YOR136W, YOR215C, YOR382W,
YOR383C, YPL054W, YPL271W, YPR127W, YAL044C, YAL054C, YAR010C,
YAR027W, YAR071W, YBL001C, YBL043W, YBL057C, YBR014C, YBR024W,
YBR035C, YBR068C, YBR111C, YBR116C, YBR147W, YBR168W, YBR246W,
YBR273C, YCR004C, YCR021C, YCR037C, YCR088W, YDL022W, YDL128W,
YDL238C, YDR003W, YDR009W, YDR033W, YDR084C, YDR104C, YDR270W,
YDR315C, YDR340W, YDR357C, YDR358W, YDR396W, YDR405W, YDR410C,
YDR434W, YDR482C, YDR487C, YDR520C, YDR534C, YDR539W, YEL011W,
YEL065W, YEL066W, YER039C, YER044C, YER067W, YER080W, YER107C,
YFL020C, YFL028C, YFL043C, YFR015C, YGL001C, YGL008C, YGL068W,
YGL073W, YGL104C, YGL113W, YGL154C, YGL167C, YGL229C, YGL242C,
YGL249W, YGL253W, YGR052W, YGR060W, YGR065C, YGR106C, YGR111W,
YGR220C, YGR257C, YHL023C, YHL048W, YHR004C, YHR037W, YHR071W,
YHR092C, YHR190W, YIL007C, YIL033C, YIL070C, YIL088C, YIL111W,
YIR002C, YIR016W, YIR035C, YIR043C, YJL012C, YJL083W, YJL089W,
YJL116C, YJL131C, YJL132W, YJL196C, YJR061W, YJR086W, YJR142W,
YJR161C, YKL008C, YKL013C, YKL041W, YKL067W, YKL138C, YKL139W,
YKL150W, YKL175W, YKR006C, YKR014C, YKR070W, YLL023C, YLR023C,
YLR093C, YLR118C, YLR142W, YLR225C, YLR241W, YLR251W, YLR252W,
YLR270W, YML030W, YML110C, YMR021C, YMR027W, YMR148W, YMR181C,
YMR262W, YMR272C, YMR298W, YNL011C, YNL130C, YNL214W, YNL259C,
YOL129W, YOR042W, YOR052C, YOR137C, YOR149C, YOR165W, YOR270C,
YOR285W, YOR367W, YPL018W, YPL156C, YPL186C, YPL203W, YPL216W,
YPL255W, YPR006C, YPR073C, YPR098C, YBR050C, YBR145W, YBR299W,
YDR518W, YEL020C, YFL062W, YGL039W, YGL134W, YJL217W, YJR159W,
YLR126C, YNL249C, YNL284C, YNL336W, YOL157C, YOR344C, YOR381W,
YPL265W, YPR124W, YBR074W, YBR109C, YBR126C, YBR201W, YCR005C,
YDL248W, YDR041W, YDR105C, YDR268W, YDR452W, YEL075C, YER046W,
YER050C, YER136W, YER159C, YGL250W, YGR019W, YGR042W, YGR053C,
YGR066C, YGR247W, YGR255C, YGR295C, YHL044W, YHR145C, YIL058W,
YIL065C, YIL083C, YIL098C, YIL172C, YJL030W, YJL185C, YJL213W,
YJR029W, YJR099W, YJR122W, YJR125C, YKL190W, YKR020W, YLL025W,
YLL051C, YLR043C, YLR090W, YLR100W, YLR108C, YLR290C, YML068W,
YMR051C, YMR139W, YMR178W, YMR193W, YNL015W, YNL079C, YNL122C,
YNL223W, YNL285W, YNL293W, YNR007C, YNR035C, YNR061C, YOL016C,
YOL104C, YOR220W, YOR221C, YOR374W, YPL123C, YPR077C, YPR107C,
YPR147C, YBR093C, YBR196C, YEL041W, YEL047C, YER023W, YER119C,
YFL055W, YGR209C, YIL124W, YKL187C, YLL055W, YMR318C, YOL152W,
YAL007C, YBR067C, YBR115C, YBR285W, YBR292C, YDL043C, YDL123W,
YDL131W, YDL168W, YDL212W, YDR056C, YDR132C, YDR154C, YDR183W,
YDR216W, YDR253C, YDR295C, YDR494W, YDR513W, YEL072W, YER045C,
YER061C, YER181C, YFL052W, YFL058W, YFR030W, YGL089C, YGL096W,
YGL114W, YGL193C, YGL202W, YGL204C, YGL259W, YGR006W, YGR070W,
YGR088W, YHL034C, YHL036W, YHR048W, YHR104W, YHR163W, YIL060W,
YIL136W, YIR024C, YJL036W, YJL045W, YJL060W, YJL101C, YJL155C,
YJR085C, YJR109C, YJR156C, YKL070W, YKL161C, YKL221W, YKR071C,
YLL009C, YLL050C, YLR092W, YLR145W, YLR156W, YLR163C, YLR220W,
YLR280C, YLR311C, YLR390W, YML116W, YMR034C, YMR038C, YMR081C,
YMR250W, YNL240C, YNL260C, YNL277W, YNR074C, YOL044W, YOL084W,
YOL147C, YOL159C, YOR184W, YOR228C, YOR255W, YPL223C, YPR160W,
YDL182W, YBR047W, YBR054W, YBR291C, YDR069C, YER124C, YER131W,
YGR044C, YIL094C, YKR007W, YMR240C, YNR050C, YOR007C, YAL015C,
YBL065W, YBR105C, YBR182C, YBR186W, YBR244W, YBR272C, YCL069W,
YDL025C, YDL059C, YDL085W, YDL113C, YDL244W, YDR018C, YDR054C,
YDR202C, YDR223W, YDR350C, YDR353W, YDR374C, YDR512C, YEL052W,
YEL070W, YER098W, YFR017C, YGL046W, YGL067W, YGL098W, YGL117W,
YGL146C, YGL240W, YGR011W, YGR067C, YGR133W, YGR153W, YGR223C,
YHR116W, YHR124W, YIL097W, YIL168W, YJL103C, YJL221C, YJR036C,
YJR095W, YKL085W, YKL133C, YKL162C, YKL188C, YKL217W, YKR061W,
YKR105C, YLL062C, YLR174W, YLR216C, YLR247C, YLR260W, YLR267W,
YLR389C, YML007W, YMR041C, YMR177W, YMR253C, YNL009W, YNL117W,
YNL128W, YNL183C, YNR073C, YOL133W, YOL158C, YOR133W, YOR225W,
YOR227W, YPL161C, YPL166W, YPL202C, YPL224C, YPR015C, YPR086W,
YPR201W, YAL061W, YAL067C, YAR007C, YBL033C, YBL056W, YBL086C,
YBR026C, YBR073W, YBR101C, YBR117C, YBR123C, YBR213W, YBR269C,
YBR280C, YCR036W, YDL132W, YDL149W, YDL200C, YDL234C, YDL242W,
YDR099W, YDR177W, YDR256C, YDR392W, YDR394W, YDR531W, YEL071W,
YER014W, YER042W, YER090W, YER184C, YFL059W, YFR042W, YFR046C,
YFR049W, YGL026C, YGL058W, YGL185C, YGL227W, YGL252C, YGL254W,
YGR089W, YGR112W, YGR134W, YGR276C, YHL019C, YHR012W, YHR017W,
YHR028C, YHR106W, YHR109W, YHR156C, YIL036W, YIL046W, YIL143C,
YIL152W, YIL159W, YIL164C, YJL071W, YJL094C, YJL154C, YJR056C,
YJR072C, YJR110W, YJR139C, YKL025C, YKL034W, YKL064W, YKL171W,
YKL196C, YKR012C, YKR068C, YKR069W, YLL001W, YLL057C, YLL061W,
YLR064W, YLR070C, YLR099C, YLR144C, YLR157C, YLR160C, YLR164W,
YLR364W, YLR421C, YML032C, YML042W, YML112W, YML118W, YMR114C,
YMR115W, YMR258C, YNL181W, YNL191W, YNL212W, YNL213C, YNL250W,
YNL265C, YNL312W, YNR032W, YOL038W, YOL049W, YOL064C, YOR088W,
YOR155C, YOR257W, YOR265W, YOR377W, YOR386W, YPL031C, YPL113C,
YPL124W, YPL151C, YPL249C, YPL260W, YPL274W, YPR048W, YPR061C,
YPR093C, YPR125W, YPR158W, YPR168W, YPR169W, YPR174C, YPR180W,
YPR193C, YPR200C, YAL014C, YAL017W, YAL049C, YBL019W, YBL058W,
YBR001C, YBR013C, YBR018C, YBR037C, YBR045C, YBR051W, YBR063C,
YBR128C, YBR129C, YBR204C, YBR241C, YBR255W, YBR281C, YCL044C,
YCL055W, YCR014C, YCR019W, YCR024C, YCR105W, YDL065C, YDL089W,
YDL143W, YDL173W, YDL193W, YDL197C, YDL206W, YDL230W, YDL233W,
YDR040C, YDR071C, YDR078C, YDR109C, YDR140W, YDR194C, YDR212W,
YDR221W, YDR257C, YDR271C, YDR287W, YDR294C, YDR316W, YDR329C,
YDR338C, YDR369C, YDR421W, YDR425W, YDR485C, YDR488C, YDR504C,
YDR505C, YDR506C, YDR515W, YEL005C, YEL037C, YEL044W, YER017C,
YER048C, YER052C, YER078C, YER089C, YER092W, YER100W, YER162C,
YER182W, YFL021W, YFL042C, YFR045W, YFR051C, YFR056C, YGL040C,
YGL041C, YGL045W, YGL057C, YGL093W, YGL105W, YGL125W, YGL166W,
YGL181W, YGL183C, YGL215W, YGL216W, YGL221C, YGL223C, YGR007W,
YGR029W, YGR155W, YGR156W, YGR186W, YGR198W, YGR210C, YGR211W,
YGR237C, YGR250C, YGR258C, YGR266W, YGR270W, YGR274C, YGR277C,
YHL021C, YHL037C, YHL038C, YHR082C, YHR083W, YHR134W, YHR160C,
YHR171W, YHR180W, YHR205W, YIL062C, YIL072W, YIL075C, YIL099W,
YIL108W, YIL165C, YIL170W, YIR009W, YIR018W, YIR031C, YIR032C,
YJL032W, YJL049W, YJL128C, YJL165C, YJR044C, YJR052W, YJR090C,
YJR091C, YJR103W, YJR104C, YJR153W, YKL059C, YKL079W, YKL090W,
YKL094W, YKL192C, YKL209C, YKR052C, YKR102W, YKR106W, YLL054C,
YLR025W, YLR097C, YLR200W, YLR226W, YLR248W, YLR266C, YLR392C,
YLR427W, YML013W, YML029W, YML041C, YML051W, YML078W, YML079W,
YML088W, YML099C, YMR056C, YMR068W, YMR091C, YMR110C, YMR160W,
YMR186W, YMR255W, YNL005C, YNL026W, YNL039W, YNL063W, YNL064C,
YNL077W, YNL083W, YNL147W, YNL176C, YNL194C, YNL253W, YNL257C,
YNL261W, YNL264C, YNL276C, YNR006W, YNR034W, YNR047W, YNR051C,
YNR071C, YOL065C, YOL067C, YOR005C, YOR008C, YOR022C, YOR023C,
YOR058C, YOR069W, YOR087W, YOR138C, YOR229W, YOR256C, YOR267C,
YPL005W, YPL020C, YPL022W, YPL105C, YPL147W, YPL150W, YPL152W,
YPL164C, YPL168W, YPL180W, YPL188W, YPL194W, YPR025C, YPR047W,
YPR049C, YPR066W, YPR081C, YPR134W, YPR140W, YPR148C, YPR155C,
YPR172W, YPR185W, YAL018C, YAR064W, YBR012C, YBR076W, YBR287W,
YDR043C, YDR250C, YDR373W, YFR014C, YGL191W, YGR180C, YHR136C,
YJL026W, YJL037W, YLR038C, YNL058C, YOR031W, YGR087C, YIL166C,
YHR008C, YIL129C, YGL256W, YJR030C, YMR077C, YBR264C, YPL177C,
YKR040C, YGL056C, YDR128W, YGR139W, YBL101W-A, YOR253W, YOL026C,
YDR278C, YHR095W, YCL042W, YNL200C, YPL221W, YLR415C, YMR058W,
YPR037C, YER072W, YML028W, YOR325W, YAL039C, YMR112C, YJR107W,
YGL088W, YJR058C, YNL142W, YDR090C, YMR071C, YBL093C, YGR293C,
YML055W, YDL017W, YDL210W, YGL055W, YCL025C, YDR080W, YDL181W,
YNR030W, YJL017W, YIL127C, YDR281C, YDR366C, YFR026C, YJL212C,
YPL215W, YEL019C, YBR132C, YHL018W, YNL196C, YPL038W, YAR047C,
YPL262W, YHL006C, YPL225W, YBR124W, YOR148C, YKR053C, YBL044W,
YER029C, YLR360W, YCL056C, YCR007C, YGR239C, YNL256W, YPR146C,
YLR377C, YKL097C, YBR066C, YLR338W, YDL229W, YBR253W, YJR027W,
YKL198C, YBL030C, YBR031W, YBR118W, YBR162C, YBR221C, YCR024C-A,
YCR106W, YDL046W, YDR012W, YDR133C, YDR134C, YDR276C, YDR342C,
YDR343C, YEL027W, YEL034W, YGR038W, YGR243W, YGR279C, YHR094C,
YHR105W, YHR175W, YHR181W, YIL056W, YIL162W, YJL059W, YJL097W,
YJL158C, YJR105W, YKL051W, YKL056C, YKL097W-A, YKL100C, YKL141W,
YKR066C, YLR134W, YLR258W, YLR339C, YML058W, YMR083W, YMR203W,
YNL209W, YNL307C, YOL030W, YOR178C, YPL028W, YPR028W, YPR113W,
YPR149W, YPR150W, YPR183W, YAL016W, YBL099W, YBL100C, YBR011C,
YBR096W, YBR100W, YBR127C, YBR283C, YBR286W, YCL008C, YCL058C,
YCR030C, YCR034W, YCR069W, YDL015C, YDL023C, YDL061C, YDL086W,
YDR038C, YDR039C, YDR050C, YDR151C, YDR178W, YDR233C, YDR284C,
YDR298C, YDR345C, YDR359C, YDR382W, YDR385W, YDR400W, YDR407C,
YDR538W, YEL024W, YEL033W, YEL063C, YER057C, YER081W, YER120W,
YFL011W, YGL012W, YGL206C, YGR022C, YGR026W, YGR082W, YGR107W,
YGR172C, YGR191W, YGR204W, YGR260W, YHL005C, YHL046C, YHR025W,
YHR026W, YHR123W, YHR126C, YHR143W, YIL011W, YIL015W, YIL018W,
YIL157C, YIR041W, YJL016W, YJL121C, YJL133W, YJL138C, YJL191W,
YJR018W, YJR047C, YJR077C, YJR119C, YJR121W, YJR123W, YJR143C,
YJR145C, YKL060C, YKL147C, YKL148C, YKL157W, YKL164C, YKL169C,
YKR033C, YLL041C, YLL064C, YLR041W, YLR044C, YLR056W, YLR058C,
YLR081W, YLR089C, YLR110C, YLR177W, YLR264W, YLR284C, YLR304C,
YLR340W, YLR354C, YLR372W, YLR388W, YML022W, YMR007W, YMR011W,
YMR015C, YMR092C, YMR101C, YMR156C, YMR205C, YMR215W, YMR261C,
YMR323W, YNL069C, YNL135C, YNL195C, YNR076W, YOL039W, YOL073C,
YOL086C, YOL120C, YOL156W, YOL161C, YOR002W, YOR009W, YOR010C,
YOR085W, YOR108W, YOR128C, YOR129C, YOR142W, YOR161C, YOR176W,
YOR230W, YOR298W, YPL004C, YPL036W, YPL048W, YPL057C, YPL059W,
YPL061W, YPL135W, YPL179W, YPL218W, YPL220W, YPL246C, YPL272C,
YPR063C, YPR080W, YPR181C, YBR290W, YCR010C, YCR091W, YDL107W,
YDL129W, YDR066C, YDR529C, YFL026W, YGL018C, YGL059W, YNL144C,
YOR003W, YAL037W, YAR023C, YBR003W, YBR020W, YBR044C, YBR091C,
YBR185C, YBR282W, YCR015C, YCR038C, YCR043C, YDL119C, YDL146W,
YDL220C, YDR057W, YDR123C, YDR125C, YDR222W, YDR225W, YDR277C,
YDR286C, YDR347W, YDR408C, YDR438W, YDR479C, YDR483W, YEL039C,
YEL057C, YEL073C, YER066W, YER076C, YER084W, YER121W, YER189W,
YFL017C, YFL046W, YFR006W, YFR008W, YGL115W, YGL208W, YGL214W,
YGL218W, YGR021W, YGR023W, YGR024C, YGR064W, YGR076C, YGR096W,
YGR108W, YGR174C, YGR182C, YGR236C, YGR288W, YHL042W, YHR195W,
YHR210C, YIL006W, YIL012W, YIL028W, YIL050W, YIL057C, YIL089W,
YIL102C, YIL113W, YIL122W, YJL100W, YJL169W, YJL199C, YJR039W,
YJR050W, YJR101W, YKL003C, YKL016C, YKL061W, YKL093W, YKL121W,
YKL160W, YKL170W, YKL194C, YKR034W, YKR067W, YLR006C, YLR016C,
YLR030W, YLR036C, YLR112W, YLR125W, YLR128W, YLR204W, YLR211C,
YLR233C, YLR257W, YLR288C, YLR326W, YLR334C, YLR395C, YLR408C,
YLR414C, YLR444C, YML050W, YML107C, YML120C, YMR031C, YMR053C,
YMR073C, YMR162C, YMR204C, YMR206W, YMR284W, YNL010W, YNL025C,
YNL127W, YNL139C, YNL217W, YOL116W, YOL118C, YOR053W, YOR100C,
YOR103C, YOR122C, YOR150W, YOR187W, YOR251C, YOR312C, YOR327C,
YOR348C, YOR352W, YOR388C, YOR394W, YPL001W, YPL033C, YPL066W,
YPL148C, YPL230W, YPL275W, YPL276W, YPR005C, YPR014C, YPR192W,
YPR194C, YBR005W, YER025W, YFL027C, YGL080W, YGL205W, YHL028W,
YHR185C, YIL076W, YJL166W, YLR046C, YMR035W, YMR238W, YMR252C,
YNL192W, YNL202W, YOL108C, YOR385W, YPR165W, YAR033W, YBL038W,
YBR009C, YBR010W, YBR151W, YCL067C, YCR096C, YDL137W, YDL192W,
YDR073W, YDR086C, YDR224C, YDR377W, YDR378C, YER015W, YGL187C,
YHR162W, YJL167W, YJL216C, YKR009C, YLR165C, YMR197C, YNL157W,
YOL002C, YOL109W, YOR180C, YPL010W, YPL233W, YBR036C, YDR297W,
YGR149W, YGR224W, YNL043C, YPL067C, YPL170W, YCR046C, YDR387C,
YFL050C, YGL051W, YHR132C, YIL112W, YJL141C, YKR098C, YLR052W,
YLR206W, YML129C, YNL203C, YNR014W, YOL043C, YOL096C, YPR184W,
YAL028W, YAL055W, YAR062W, YBL095W, YBL102W, YBR122C, YBR157C,
YBR161W, YBR251W, YBR298C, YCR039C, YCR083W, YDL018C, YDL067C,
YDL078C, YDL091C, YDL215C, YDL216C, YDR022C, YDR067C, YDR079W,
YDR181C, YDR186C, YDR196C, YDR262W, YDR306C, YDR319C, YER188W,
YGL004C, YGL035C, YGR036C, YGR062C, YGR120C, YGR131W,
YGR141W, YGR167W, YGR287C, YHL024W, YHR080C, YHR097C, YIL077C,
YJL046W, YJL070C, YJL096W, YJL113W, YJL146W, YJL180C, YJR019C,
YJR049C, YKR058W, YLL005C, YLR078C, YLR151C, YLR271W, YLR295C,
YLR351C, YLR375W, YMR023C, YMR025W, YMR135C, YMR210W, YMR267W,
YMR278W, YMR293C, YNL073W, YNR037C, YNR040W, YNR072W, YOR028C,
YOR316C, YOR328W, YOR363C, YPL039W, YPL040C, YPL099C, YPL107W,
YPL134C, YPL138C, and YPL140C.
[0008] The base sequences of those yeast genes and the amino acid
sequences of the corresponding protein are disclosed in public
databases such as MIPS in Germany: Munich Information Center for
Protein Sequence, and SGD in USA: Saccharomyces Genome Database,
and are known via the internet.
[0009] In addition to the yeast genes as described above, genes
that are homologous to the yeast genes and are derived from other
species may be used in the invention. In this context, "a gene(s)
that is (are) homologous to the yeast genes" means genes that
comprise a base sequence having a homology of 50% or more,
preferably 80% or more to the base sequences of yeast genes, and
that encode a protein having the same functions as the proteins
encoded by the yeast genes.
[0010] Cells as used herein may be either eukaryotic or prokaryotic
cells as long as they comprise the genes as described above.
Preferred cells are yeast cells.
[0011] Methods for detecting mRNA have been previously known, and
any one of those methods may be used in the present invention.
[0012] As an embodiment of the invention, mRNA is detected through
reverse transcription-PCR. Reverse transcription-PCR is well known
in the art. See, for example, NAKABEPPU Yusaku, et al.: Cell
Technology, suppl. Tips series, Modified PCR Tips, Shujunsha Co.
Ltd., 1999, pp 25-43. For example, the invention comprises:
(1) adding a test material to the cell, and incubating the
mixture;
(2) extracting mRNA from the cell;
(3) preparing cDNA from the mRNA via reverse transcription using
labeled nucleotides; and
(4) hybridizing the cDNA as used as probe with the gene as
described above.
[0013] Incubation of cells may be conducted using usual media and
usual temperatures. Test materials comprising a chemical substance
to be tested are added to the medium, and the cells are incubated
further for several hours. Concentrations of the test materials are
selected to not lead to cell death. Test materials may comprise one
or more chemical substances.
[0014] For methods of extraction of mRNA, it is well known that a
polynucleotide having a poly T structure which is immobilized on
the surface of magnetic beads or latex beads is used to trap the
mRNA, and then the mRNA is washed and eluted with spine column in
view of the fact that a poly A chain is attached to the 3' terminus
of mRNA, which is readily conducted using a commercially available
kit such as Oligotex-dT30<Super>mRNA Purification Kit,
Takara. The mRNA is reverse-transcribed with a reverse
transcriptase (Super Script II Reverse Transcriptase; catalogue No.
18064-014, GibcoBRL) using fluorescence-labeled nucleotides. As
such, labeled cDNAs that are introduced with fluorescence-labeled
nucleotides during the reverse transcription are obtained. Reverse
transcriptases and nucleotides that are labeled with Cy3-dUTP or
Cy5-dUTP are also commercially available (for example, Super Script
II Reverse Transcriptase; catalogue No. 18064-014, GibcoBRL).
Fluorescence-labeled cDNAs are detected with a
fluorophotometer.
[0015] RT-PCR is a procedure for detection and quantitative
determination of an intended RNA in a form of the amplified cDNA,
which comprises reverse-transcribing mRNA into cDNA with a reverse
transcriptase, and conducting PCR using the cDNA as a starting
material as well as specific primer sets and a thermostable DNA
polymerase.
[0016] In the present step, a microarray containing the gene as
described above (DNA tip) may be prepared to hybridize them with
the cDNAs, thereby facilitating the efficient detections, which is
a preferred embodiment of the present invention.
[0017] As another embodiment of the invention, the mRNA is detected
by northern blotting. Northern blotting is well-known in the art
(OGATA Nobukuni, NOJIMA Hiroshi: Genetic Engineering Keywords Book,
revised 2nd ed., Yodosha, co.jp, 2000, pp 299-301). For example,
the process comprises
(1) adding a test material to the cell, and incubating the
mixture;
(2) extracting mRNA from the cell; and
(3) hybridizing the mRNA with the gene as described above.
[0018] Procedures of northern blotting comprises electrophoresing
the RNA, transferring the pattern to a filter, and hybridizing it
with a specific probe labeled with an isotope, thereby analyzing
the presences and the amount of the mRNA in a sample as well as the
length of the same.
[0019] In the present step, a microarray containing the gene as
described above (DNA tip) may be prepared to hybridize them with
the cDNAs, thereby facilitating the efficient detections.
[0020] In further another embodiment of the present invention, the
detection of mRNA is conducted by detecting the production of a
polypeptide encoded by the yeast gene as described above. The
production of a polypeptide may be detected for example using an
antibody directed to the polypeptide.
[0021] Toxic substances to be detected according to the present
invention include arsenic, cadmium, mercury,
4-nitroquinolin-N-oxide, 2,4,5-trichlorophenol,
.gamma.-hexachlorocyclohexane, manganese
ethylenebis(dithiocarbamate),
2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile, tetramethylthiuram
disulfide, Zinc N,N'-ethylenebis(dithiocarbamate), gingerol,
acrolein, and dimethylsulfoxide, all of which are mutagenic.
[0022] The following examples are presented for purpose of further
illustration of the invention, and such examples are not intended
to be limiting the invention in any respect.
EXAMPLES
Example 1
[0023] Yeast (Saccharomyces cerevisiae S288C (a SUC2mal mel gap2
CUP1)) were incubated at 25.degree. C. on YPD medium (yeast extract
1%, polypepton 2%, glucose 2%). One of toxic chemical substances
was added to the cells at logarithmic growth phase, and the cells
were further incubated for two hours. Cells were cultured without
any chemical substance in the same condition, and were used as
control. Concentrations of the chemical substances were defined to
inhibit the growth of the yeast but not lead to death.
TABLE-US-00001 Chemical Substances Concentrations (1) Na.sub.2As
0.3 mM (2) CdCl.sub.2 0.3 mM (3) HgCl.sub.2 0.7 mM (4) PbCl.sub.2 2
mM (5) 4-nitroquinolin-N-oxide 0.2 .mu.M (6) 2,4,5-trichlorophenol
16 .mu.M (7) .gamma.-hexachlorocyclohexane 1.3 mM (8) manganese
ethylenebis(dithiocarbamate) 2 ppm (9)
2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile 10 .mu.M (10)
Tetramethylthiuram disulfide 75 .mu.M (11) zinc
N,N'-ethylenebis(dithiocarbamate) 2 ppm (12)
8-methyl-N-vanillyl-6-nonenamide 0.82 mM (13) gingerol 1.36 mM (14)
acrolein 0.20 mM (15) dimethylsulfoxide 1.41M (16) Roundup
(trademark, herbicide).sup.1) 1500-fold dilution (17) sodium
dodecylbenzosulfonate 0.02% (18) sodium lauryl sulfate 0.01%
.sup.1)N-(phosphomethyl) glycinate ammonium41.0%, surfactant
59.0%
[0024] After completion of the incubation, the culture was
centrifuged to collect the cells. To the cells, sodium acetate
buffer (50 mM sodium acetate, 10 mM EDTA, 1% SDS) was added, and
the mixture was shaken at 65.degree. C. for five minutes, followed
by returning to room temperature, and obtaining the supernatant, of
which the procedures were repeated two times. To the supernatant,
1/2 amount of a solution of phenol/chloroform was added, and the
mixture was centrifuged to give a supernatant, which was added with
an equal amount of chloroform, and the mixture was centrifuged to
give a supernatant. To the supernatant, an equal amount of
isopropanol containing 0.3 M sodium acetate was added, and the
mixture was allowed to stand at room temperature for 30 minutes,
after which the mixture was centrifuged to give a sediment of the
whole RNAs. Seventy % ethanol was added to the sediment, and the
mixture was again centrifuged to give a sediment, which was then
dried and dissolved in water. mRNA was isolated from the whole RNAs
as followings. In view of the fact that a poly A chain is attached
to the 3' terminus of mRNA, a polynucleotide having a poly T
structure which was immobilized on the surface of latex beads was
used to trap the mRNA, and then the mRNA was washed and eluted with
spine column (Oligotex-dT30<Super>mRNA Purification Kit,
Takara). Reverse transcription of the mRNA was conducted with a
reverse transcriptase (Super Script II Reverse Transcriptase;
catalogue No. 18064-014, GibcoBRL) using fluorescence-labeled
nucleotides to give cDNAs that were introduced with Cy3-dUTP or
Cy5-dUTP during the reverse transcription.
[0025] The labeled cDNAs were dissolved in TE buffer (10 mM
Tris-HCl/1 mM EDTA, pH8.0), and the solution was dropped on the DNA
chip containing the whole genes of yeast (DNA Chip Research Inc.
Japan) so that the cDNAs were hybridized on the DNA chip at
65.degree. C. for over 12 hours. The fluoresces intensity of the
DNA chip was read with a scanner, and the ratio relative to the
fluorescence intensity resulting from the absence of chemical
substance was estimated as the following, which is shown in Tables
1 to 9: The .times. .times. level .times. .times. of .times.
.times. expressed .times. .times. mRNA .times. .times. in .times.
.times. the .times. .times. presence .times. .times. of .times.
.times. chemical .times. .times. substance The .times. .times.
level .times. .times. of .times. .times. expressed .times. .times.
mRNA .times. .times. in .times. .times. the .times. .times. absence
.times. .times. of .times. .times. chemical .times. .times.
substance ##EQU1## TABLE-US-00002 TABLE 1 Unknown protein yeast
genes The level of expressed mRNA in the presence of chemical
substance/The level of expressed mRNA in the absence of chemical
substance yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11)
(12) (13) (14) (15) (16) (17) (18) Intensity YCR102C 3.4 3.2 2.4
1.1 0.7 0.4 1.1 4.9 9.8 61.5 13.5 0.5 1.1 4.1 0.9 1.2 1.1 1.2 0.53
YDL218W 3.5 1.2 2.6 1.4 0.7 0.9 1.1 1.5 72.5 12.6 5.7 0.9 1.1 4.8
1.1 3.5 1.1 0.9 0.42 YDR533C 3.4 4.9 3.5 1.8 1.3 2.2 1.7 5.4 7.3
12.7 7.7 1.4 3.0 2.9 2.5 6.7 2.3 2.7 1.82 YGR110W 1.6 3.1 2.2 5.9
0.9 0.9 1.7 1.5 6.4 4.8 0.5 1.4 3.6 2.8 1.2 17.1 0.9 2.1 0.19
YKL071W 8.3 3.8 5.4 2.8 1.1 18.6 3.7 24.7 162.2 109.2 40.3 1.0 8.4
21.9 1.7 2.2 1.0 0.9 0.31 YLR460C 2.1 2.1 2.0 1.1 1.3 0.6 1.1 8.1
13.9 31.6 14.3 0.4 0.7 3.5 0.7 1.8 1.0 1.1 0.48 YMR090W 6.9 9.5 2.3
3.5 0.7 3.8 2.7 3.9 16.7 6.1 8.8 2.2 6.9 6.5 1.9 5.1 1.8 2.8 1.30
YOL150C 4.1 3.7 9.9 0.9 1.0 5.2 2.4 3.7 10.8 8.3 9.4 2.9 8.9 5.7
1.8 3.1 2.7 2.2 0.47 YBL048W 2.0 7.9 2.3 2.8 1.3 2.0 1.9 1.2 7.2
4.4 2.0 1.2 2.7 2.0 4.1 5.7 1.3 1.0 0.29 YBL107C 1.4 1.1 0.4 1.5
1.2 1.1 2.1 1.9 1.0 3.1 2.9 1.4 2.6 2.5 1.4 1.5 0.9 1.4 1.03
YFL024C 1.0 1.1 1.1 0.7 1.1 2.0 3.3 0.9 0.5 0.5 0.6 0.8 0.9 3.3 0.9
1.1 0.9 0.8 0.37 YGL121C 2.6 5.0 1.4 4.2 0.9 9.8 4.7 3.0 7.0 15.0
6.1 1.6 7.8 5.8 1.6 8.5 2.7 3.5 0.60 YHR029C 2.8 1.8 1.8 1.8 1.0
2.7 2.0 2.7 13.6 8.6 3.8 1.5 4.7 3.5 1.0 1.0 2.1 2.1 0.87 YHR209W
2.8 1.1 0.8 4.5 1.8 3.2 5.0 2.0 2.9 6.4 3.3 1.0 2.0 2.2 5.0 3.5 2.6
2.6 0.56 YKL107W 2.4 2.5 0.5 0.8 1.1 2.0 1.1 0.9 28.2 8.3 2.0 1.0
1.9 3.4 1.7 3.5 1.6 0.9 0.17 YKR075C 1.5 0.7 2.7 4.5 1.2 1.5 1.4
2.0 0.2 0.6 1.3 2.3 3.8 2.7 0.4 4.3 2.4 1.9 1.15 YLL056C 2.1 2.3
3.0 2.0 1.1 0.6 1.0 1.3 58.8 8.8 1.7 1.3 6.8 11.0 1.5 4.8 5.3 2.5
0.32 YLR297W 2.4 2.1 3.5 1.7 1.3 0.8 1.1 1.3 2.1 5.5 3.5 0.8 0.8
2.3 0.7 1.8 0.7 1.0 0.81 YOR338W 1.8 1.8 0.5 1.7 1.6 2.6 1.3 2.2
0.6 3.5 0.8 1.2 1.4 2.5 1.8 1.0 1.1 0.5 0.52 YOR391C 2.1 2.0 0.9
1.2 1.3 1.6 2.0 2.8 18.8 18.1 3.2 1.1 2.3 2.4 5.8 2.2 1.0 0.9 0.22
YPL280W 1.7 1.9 1.9 2.0 1.4 1.9 1.8 2.3 49.8 14.0 1.9 0.9 2.4 2.4
4.3 1.5 1.2 0.9 0.22 YLR346C 4.4 2.0 2.1 4.5 1.4 5.5 5.6 1.3 8.6
6.6 0.5 4.2 6.2 2.2 1.0 2.4 10.6 7.8 0.53 YOR049C 2.5 0.9 12.8 1.4
1.3 8.4 4.2 0.9 1.1 1.9 1.1 6.7 7.1 1.5 1.3 4.3 2.6 2.9 0.22
YAL034C 1.1 1.8 2.8 1.1 1.0 1.5 1.8 1.0 3.0 3.3 1.5 2.8 4.9 1.2 1.4
1.0 1.2 1.3 0.52 YDR476C 0.7 1.8 6.0 1.2 0.5 3.1 1.5 1.3 1.7 3.4
1.6 2.1 2.8 1.1 2.2 2.0 2.4 1.5 0.58 YGR035C 1.6 0.6 1.2 0.6 1.3
3.3 1.1 0.9 1.1 0.5 0.4 3.3 2.1 0.8 0.3 1.9 2.5 4.3 1.04 YGR284C
1.0 2.0 4.0 1.4 1.2 1.4 2.2 1.1 4.3 1.8 1.7 2.1 3.6 1.2 3.9 1.9 1.3
2.1 2.57 YHR054C 1.7 0.9 2.2 1.0 1.0 2.9 1.6 1.8 2.6 7.7 0.9 3.6
5.8 1.0 0.8 2.2 5.1 3.4 0.80 YLR008C 0.9 0.5 0.7 0.9 1.3 2.7 2.0
1.0 0.4 0.7 0.8 3.5 6.2 1.6 0.7 1.7 5.4 4.9 2.00 YMR315W 4.3 1.8
1.7 4.2 2.9 2.0 2.4 2.6 3.2 2.0 2.5 1.3 2.5 1.6 2.1 2.8 1.76
YNL211C 1.2 1.0 0.8 1.0 1.0 7.4 3.1 1.1 0.8 1.1 1.1 3.2 9.9 1.1 0.8
9.3 4.2 6.8 0.52 YOL031C 0.9 1.9 1.0 1.7 1.2 1.0 2.5 2.1 2.3 1.4
1.3 2.1 2.4 1.1 4.4 1.5 1.2 1.9 1.20 YOL101C 0.9 0.8 0.4 1.7 1.6
0.5 0.7 0.9 0.1 0.3 0.9 2.4 0.2 0.8 0.6 3.5 0.6 0.6 1.37 YAR031W
1.5 1.1 1.1 1.7 1.1 2.9 1.6 1.2 2.7 1.6 1.4 1.2 3.3 1.4 0.9 3.5 1.6
2.5 1.00 YBL049W 2.9 11.8 2.1 2.9 1.1 1.7 1.9 5.2 5.2 2.2 0.7 3.9
1.5 7.2 6.4 1.1 1.1 0.47 YBR062C 1.3 1.7 0.4 1.2 1.4 1.9 1.5 1.9
5.4 2.2 2.3 1.2 2.8 2.6 0.7 2.2 1.4 1.6 0.93 YCR013C 1.3 1.4 5.0
1.1 1.1 1.8 1.6 0.7 0.8 1.3 2.4 1.4 3.9 1.5 1.6 1.6 1.1 1.3 2.80
YDL027C 1.2 2.0 1.7 1.7 1.2 2.1 2.9 1.5 2.0 2.3 1.7 1.7 3.2 1.1 1.4
1.8 1.4 2.0 0.69 YDL110C 1.5 1.4 1.1 2.1 0.8 1.7 2.5 1.8 3.0 2.3
1.9 1.5 2.7 2.7 1.3 3.6 2.0 4.4 1.27 YDL169C 1.7 1.7 1.1 1.3 1.1
2.6 2.1 1.3 7.3 4.7 1.2 1.2 3.7 2.7 2.2 3.8 1.5 1.6 0.42 YDR070C
2.2 6.4 3.6 3.5 0.9 6.2 1.4 1.9 13.9 6.0 4.1 4.3 6.6 2.0 2.1 15.1
1.2 3.1 0.44 YDR210W 1.1 1.0 0.9 1.0 2.0 1.2 1.5 1.4 0.5 1.0 1.0
1.0 2.3 1.1 1.0 1.5 1.9 1.9 1.82 YDR214W 1.3 4.0 4.5 1.3 1.1 1.7
1.5 1.5 5.5 2.4 1.9 1.1 5.3 1.2 1.1 0.7 1.2 1.0 1.07 YDR435C 1.2
1.1 1.2 1.4 1.2 2.5 2.1 1.2 0.8 2.1 1.3 1.1 2.5 1.3 0.6 2.0 1.3 2.0
1.30 YER037W 2.0 2.1 0.8 1.1 1.3 3.2 2.6 1.0 1.0 5.5 1.5 1.2 3.0
1.7 0.8 1.8 1.7 2.6 1.17 YFL044C 1.0 1.5 0.8 2.3 1.6 1.3 1.6 1.4
5.2 3.7 2.2 1.2 4.7 1.2 1.0 1.8 1.3 1.4 0.50 YFR003C 1.2 1.5 0.8
1.6 1.0 2.2 1.4 1.4 8.3 3.1 1.4 0.9 2.5 2.1 1.0 1.4 1.3 1.8 1.01
YFR020W 1.0 0.9 1.2 1.0 0.9 1.4 1.1 0.9 3.7 3.5 1.4 0.9 2.3 1.8 2.6
1.0 1.2 0.9 0.61 YFR044C 0.9 1.3 3.8 1.1 0.9 2.1 1.2 0.8 2.1 2.2
1.9 1.2 3.1 0.8 1.5 1.2 1.0 1.0 1.99 YGR010W 1.2 1.6 0.9 1.2 0.8
1.2 1.7 1.6 13.6 8.9 1.5 0.9 5.2 1.9 1.3 1.4 0.8 1.3 0.55 YGR142W
2.7 6.2 15.3 1.3 1.3 0.9 1.4 1.5 36.8 12.2 2.3 2.0 8.9 0.9 1.3 0.3
1.9 1.5 1.28 YGR161C 2.0 2.2 5.4 3.8 1.0 1.4 1.4 1.3 2.0 3.8 0.8
1.7 2.8 0.9 1.7 1.1 1.5 1.8 0.65 YGR212W 1.5 1.7 1.5 1.3 1.2 1.0
1.1 3.8 0.9 1.5 10.0 1.1 1.1 2.1 3.9 2.2 0.28 YGR268C 1.1 2.3 2.0
2.5 1.1 1.1 1.0 1.1 4.1 1.6 0.8 1.0 2.8 1.0 1.5 1.2 1.5 1.4 0.48
YHR016C 0.8 1.5 1.7 1.5 1.8 3.7 0.8 2.8 2.0 2.2 1.3 3.3 0.9 0.6 2.1
1.2 1.4 0.51 YHR087W 1.2 2.7 8.6 2.8 0.7 4.2 3.4 1.2 4.1 3.9 3.7
1.4 4.0 1.5 1.9 3.8 1.2 2.9 1.34 YJL048C 1.7 2.5 2.0 2.9 0.9 1.5
0.7 1.5 1.2 3.8 3.2 1.1 2.4 1.7 0.6 2.3 1.6 2.5 0.82 YJL144W 1.9
1.6 2.2 1.6 1.2 1.7 1.7 1.3 14.6 8.9 3.0 0.8 3.9 1.6 1.0 2.5 2.2
2.4 0.60 YJL163C 1.2 1.9 1.7 1.5 0.9 2.8 2.3 0.7 14.5 2.5 3.1 2.0
4.5 1.0 2.0 2.8 1.5 1.7 0.28 YJR074W 1.0 1.4 2.0 2.0 0.7 1.2 1.8
1.3 3.7 3.1 1.2 2.0 2.8 1.7 3.4 1.5 1.8 1.9 0.68 YKL065C 1.9 2.0
1.3 1.7 1.0 2.3 3.8 1.8 3.1 3.9 1.3 1.3 3.0 2.1 1.7 2.8 2.8 4.6
2.29 YKR011C 1.1 1.6 0.9 1.6 1.2 2.3 2.7 2.0 4.7 4.4 1.5 1.1 3.5
1.4 1.8 1.3 1.3 1.9 0.66 YKR018C 0.7 1.1 1.7 0.7 0.9 1.7 1.0 0.7
3.9 1.7 1.4 1.0 3.0 1.1 1.0 1.8 1.0 1.2 0.98 YKR046C 1.9 7.8 2.8
1.8 0.6 1.9 1.3 0.8 3.9 2.0 2.6 1.3 2.8 1.9 2.9 3.5 1.2 1.9 0.73
YKR049C 1.6 4.2 1.0 3.2 0.9 3.0 2.4 1.3 2.2 3.2 2.2 1.2 4.1 2.1 0.9
4.2 1.6 3.3 1.17 YLR132C 1.0 1.1 0.3 1.1 1.2 1.1 1.1 0.7 4.5 2.5
0.5 1.0 2.7 1.3 2.3 1.6 1.2 1.6 0.36 YLR161W 0.9 0.8 0.8 0.7 0.9
1.2 1.3 0.8 1.0 1.5 1.5 0.8 2.1 1.0 0.6 1.1 1.1 0.9 0.33 YLR217W
0.9 2.0 2.1 0.7 1.4 1.4 1.5 1.0 3.2 8.2 0.9 3.8 0.9 0.9 0.8 1.0 1.2
0.35 YLR328W 1.3 1.2 1.3 0.9 0.9 4.8 5.4 1.1 0.9 1.2 1.4 1.2 4.3
0.5 0.8 1.4 1.1 0.8 1.04 YML128C 1.5 3.3 4.1 4.1 0.5 5.1 2.8 1.1
5.1 3.1 2.9 1.4 4.9 1.4 2.6 5.6 2.0 5.5 1.66 YMR040W 3.1 2.9 0.9
2.8 1.7 2.8 5.1 1.7 1.4 1.4 1.5 2.1 5.2 1.8 2.0 2.7 3.1 3.7 0.62
YMR251W 1.3 1.3 1.8 0.6 2.2 1.6 3.1 1.7 3.1 11.6 2.8 1.2 2.5 1.5
0.4 1.3 1.5 0.9 0.20 YMR322C 2.0 4.3 1.5 2.9 1.4 1.8 1.7 2.1 21.3
10.3 3.2 1.1 2.1 2.7 3.6 1.8 1.4 0.8 0.18 YNL094W 0.9 1.4 1.1 1.0
1.4 2.9 1.2 2.0 3.5 2.6 1.7 1.2 3.4 1.0 1.5 1.5 1.1 1.3 0.66
YNL134C 2.3 6.0 4.5 0.9 1.7 1.4 1.5 3.2 6.1 5.9 5.0 1.1 3.1 1.4 0.8
2.1 1.3 2.0 2.51 YNL155W 1.1 1.2 1.1 0.9 1.4 3.0 1.3 1.7 5.8 2.7
2.2 1.1 4.4 2.1 2.0 2.0 1.1 1.6 1.89 YOR059C 1.2 1.2 0.4 0.9 1.4
1.1 2.2 1.3 7.6 4.6 1.0 1.0 3.3 2.2 3.5 1.8 1.3 1.7 0.71 YOR152C
4.5 2.5 3.4 2.9 0.8 4.5 3.2 1.2 10.0 5.0 2.7 2.9 7.4 1.7 3.6 2.1
4.0 2.2 0.42 YOR173W 0.7 2.3 6.3 2.0 0.9 3.5 4.9 1.4 5.2 3.7 2.3
1.9 3.8 2.8 0.7 5.7 1.7 3.8 0.54 YOR289W 1.6 1.5 1.0 2.0 1.2 4.2
6.1 2.4 2.4 1.7 2.6 1.5 4.3 2.0 1.6 3.0 2.3 3.9 0.74 YPR030W 1.7
1.4 1.4 1.0 1.2 1.3 1.2 0.9 2.5 2.4 1.2 1.4 3.2 1.5 1.5 3.1 1.4 2.1
0.30 YAL008W 1.4 2.4 2.0 2.4 0.7 1.6 1.9 1.3 1.8 1.5 2.2 1.3 2.2
2.6 0.9 4.2 1.4 1.9 1.04 YBR053C 1.0 1.6 2.4 2.4 1.6 2.7 4.1 1.2
2.9 2.1 2.3 1.1 2.4 1.0 0.7 2.8 1.9 2.4 1.25 YBR099C 1.0 1.4 7.2
1.8 1.0 0.5 0.9 1.5 3.4 12.9 0.4 1.0 2.1 1.6 0.8 0.5 0.8 0.9 0.47
YBR137W 1.1 2.2 1.4 3.5 0.9 2.4 2.7 2.0 2.2 1.8 2.4 1.4 2.1 1.8 0.6
2.8 1.4 2.6 1.40 YBR203W 1.4 1.4 1.6 2.4 0.9 0.6 0.9 1.3 1.1 1.8
1.3 1.6 2.4 1.3 1.0 18.0 1.4 2.2 0.38 YCL049C 1.9 1.3 1.4 1.2 1.6
2.3 2.1 1.0 2.0 1.9 1.6 1.4 2.4 1.8 1.4 2.1 1.4 1.4 0.86 YCR082W
1.4 1.2 0.7 1.2 1.3 1.3 1.5 1.5 4.3 2.3 2.0 1.0 2.0 2.4 1.6 2.2 1.2
1.7 1.62 YDL054C 1.3 2.2 2.7 1.1 1.2 1.2 0.9 0.7 3.5 2.1 2.1 1.1
2.7 1.2 1.0 1.0 1.0 1.0 0.92 YDL115C 1.4 1.0 0.5 1.8 0.8 1.5 1.8
1.6 6.6 3.6 1.8 1.1 1.9 2.3 1.2 1.6 1.3 1.8 0.83 YDL144C 0.8 0.9
1.2 1.5 1.0 1.8 1.0 0.9 3.6 1.2 1.9 1.0 2.1 1.2 1.0 1.1 0.9 0.9
0.52 YDL223C 0.7 1.1 5.0 2.5 0.9 0.8 1.0 0.3 3.8 1.5 5.2 1.0 3.1
1.3 3.1 7.2 0.9 1.0 0.32 YDR032C 1.7 2.2 3.5 2.5 1.4 2.7 2.8 2.4
3.1 2.9 3.3 1.8 2.9 2.8 1.3 3.8 1.9 3.5 3.50 YDR330W 0.8 1.5 1.2
0.8 1.2 2.3 1.3 1.1 3.9 2.6 0.9 1.0 2.2 1.1 1.6 1.4 1.5 1.3 0.53
YDR411C 0.9 2.8 1.8 1.2 1.6 0.8 2.0 0.9 0.7 1.0 1.3 1.5 1.9 0.8 4.1
1.5 1.5 1.3 0.56 YDR511W 1.3 1.7 0.9 2.3 1.0 2.0 1.5 1.7 2.5 2.2
1.2 0.8 3.1 2.2 0.8 2.2 1.3 1.5 0.66 YDR545W 0.6 1.2 0.6 0.7 1.4
1.0 1.2 0.6 1.8 0.7 0.7 0.9 2.0 0.7 0.9 0.9 0.9 0.9 1.06 YER004W
1.0 1.5 1.9 1.4 1.5 1.2 1.4 1.1 4.5 2.9 2.2 1.7 4.6 1.8 1.4 2.3 1.4
1.2 1.48 YER035W 1.4 1.6 1.6 1.9 1.5 0.9 1.9 1.2 1.2 1.4 1.4 1.1
1.9 1.0 0.9 2.1 2.2 2.1 0.85 YER079W 1.1 1.6 1.9 2.0 0.8 1.5 1.9
1.4 5.3 3.4 2.1 0.9 2.1 1.6 0.5 1.4 1.0 1.6 0.69 YER158C 1.2 0.9
0.9 3.1 0.8 0.7 1.2 0.9 2.1 1.6 2.3 1.0 3.1 0.9 0.6 1.6 1.6 1.2
0.61 YER163C 1.1 2.4 1.2 1.6 0.8 2.0 1.5 1.4 5.4 3.4 1.6 1.0 2.9
1.9 1.6 2.4 1.2 1.2 0.62 YER175C 0.9 1.2 1.3 2.2 0.9 0.8 2.3 1.1
1.9 11.5 1.1 0.9 4.3 1.1 1.3 2.8 0.9 1.2 0.53 YFL006W 0.8 2.8 1.6
1.0 1.4 1.2 1.0 1.0 3.2 1.7 1.2 1.2 3.1 1.7 2.4 1.1 1.0 0.8 0.82
YFL010C 1.0 4.8 1.3 1.0 1.3 1.9 1.5 1.0 3.1 1.4 1.4 1.5 3.3 1.4 1.7
1.4 1.9 1.6 0.77 YFL032W 0.4 1.5 1.6 0.8 0.9 0.6 1.1 0.4 0.5 0.6
1.1 0.7 2.4 0.6 2.0 0.7 1.7 0.8 1.62 YGL037C 1.5 2.7 6.5 2.1 0.9
1.3 2.9 1.2 2.1 1.6 3.9 0.8 2.3 1.0 0.8 1.5 1.3 2.6 4.58 YGL047W
1.0 1.9 1.6 2.3 1.3 1.5 1.7 1.1 4.5 5.7 1.9 1.1 2.6 2.3 1.7 2.9 1.1
1.2 0.97 YGL053W 1.5 1.5 1.2 2.5 2.0 2.7 3.7 1.2 3.3 2.4 1.3 1.3
3.3 1.1 1.1 3.9 2.2 3.7 1.26 YGL199C 1.1 1.7 1.7 1.0 0.7 0.7 1.3
0.7 0.1 0.9 2.0 0.8 1.6 1.6 1.2 1.0 0.36 YGR101W 1.0 1.3 1.2 1.1
1.2 0.9 1.5 0.8 4.0 1.4 2.0 1.0 2.4 0.9 1.1 2.0 1.0 1.1 1.04
YGR130C 0.9 0.7 0.6 1.6 1.4 0.9 1.3 0.9 2.0 1.5 0.8 0.7 1.9 0.9 1.2
2.2 1.3 1.6 0.78 YGR154C 1.8 2.9 2.2 0.5 1.2 1.4 2.0 1.7 25.2 9.1
1.5 0.9 2.5 2.2 0.7 2.0
1.0 1.2 0.36 YGR221C 0.9 2.2 0.9 1.4 0.9 3.0 1.2 1.1 0.7 0.5 1.6
2.3 1.4 1.5 2.7 1.3 1.3 0.29 YHR138C 2.8 1.8 2.2 2.8 1.5 3.8 3.0
1.4 5.3 4.6 1.6 1.8 4.0 3.4 2.2 3.3 5.0 7.1 1.89 YHR199C 1.9 2.0
3.2 2.0 1.2 1.1 1.1 1.0 8.6 6.0 1.9 1.1 2.1 2.0 2.8 3.3 1.1 0.9
0.63 YIL041W 1.0 1.2 2.1 1.3 0.5 1.0 0.8 0.9 1.8 1.4 1.4 1.0 2.3
1.3 1.3 0.7 0.8 1.1 1.33 YIL087C 1.3 1.9 3.4 1.6 1.4 4.1 1.8 1.1
2.4 1.8 2.8 1.1 2.4 1.3 0.4 5.6 1.7 1.6 0.68 YJL057C 1.5 1.2 1.6
1.7 1.5 1.4 2.7 1.5 7.3 6.1 2.0 1.0 2.5 1.6 1.4 1.9 1.4 1.5 0.51
YJL066C 0.9 1.2 1.2 2.5 0.8 1.4 1.6 0.8 2.0 2.1 0.8 1.0 2.2 1.0 1.3
2.8 1.4 1.5 0.43 YJL082W 1.4 0.8 2.4 1.1 1.7 0.2 0.4 0.9 1.4 2.9
1.0 1.3 2.1 0.5 3.2 0.2 0.6 0.3 2.07 YJL151C 1.0 2.4 3.2 1.2 1.3
2.2 1.4 0.8 0.5 1.6 1.0 1.3 2.4 1.3 1.0 2.5 3.5 2.4 1.69 YJL152W
0.9 1.5 1.8 1.3 1.6 1.5 1.2 0.7 0.3 1.0 1.0 1.0 1.8 1.4 0.8 1.6 2.5
1.7 0.80 YJL161W 1.7 2.2 1.5 4.6 1.1 8.0 3.6 1.4 3.1 2.1 3.7 1.0
2.5 2.2 0.6 4.4 1.9 2.1 0.44 YJL171C 2.3 0.7 2.8 1.4 1.0 2.7 1.4
0.9 1.0 1.7 2.2 1.0 2.9 1.0 1.8 1.0 3.6 2.9 1.94 YJR008W 1.6 1.5
1.2 1.7 1.4 2.2 2.9 1.1 1.8 1.9 1.4 1.3 2.0 1.2 0.9 3.3 1.5 2.7
0.87 YKL151C 1.2 3.1 1.7 2.5 1.0 2.0 5.6 1.0 3.3 3.5 2.3 1.0 2.0
1.3 1.4 3.7 1.4 1.8 1.02 YKL153W 1.1 1.4 2.0 0.7 1.0 2.9 1.1 0.7
0.8 1.4 2.1 1.1 2.4 1.1 1.5 1.1 0.9 1.3 1.60 YKL195W 0.8 0.5 0.4
1.1 1.9 2.5 2.1 1.2 3.6 2.1 1.0 1.1 2.4 1.6 0.9 1.7 1.4 1.6 1.58
YLR054C 2.0 1.5 0.4 2.4 1.3 1.2 1.1 1.1 2.7 1.1 0.7 1.1 3.2 1.1 0.7
0.9 1.6 1.1 0.14 YLR149C 1.4 1.9 3.4 2.3 0.8 1.4 1.6 1.1 6.2 5.2
2.8 2.0 3.0 1.2 1.3 2.8 1.3 3.0 0.33 YLR152C 0.7 1.3 1.1 0.9 1.1
2.1 1.4 1.2 0.6 1.1 3.6 1.0 2.8 1.2 0.8 2.8 1.5 1.8 0.46 YLR324W
0.7 1.2 0.9 1.0 1.3 1.2 1.0 1.0 3.1 1.4 0.9 0.8 2.3 1.4 1.6 1.7 1.2
1.2 0.49 YLR350W 1.2 1.9 3.2 2.3 0.8 1.6 1.2 1.0 0.6 1.4 0.9 1.8
4.5 2.8 1.6 2.9 1.6 1.1 1.52 YLR387C 0.9 1.6 0.8 0.6 1.3 1.9 1.1
1.4 7.8 3.0 0.9 1.1 3.6 1.7 1.9 1.0 1.0 1.4 1.20 YML117W 0.9 2.2
0.9 1.6 0.8 1.0 0.7 0.7 1.0 1.4 0.8 0.8 2.0 0.8 2.8 0.7 1.1 1.3
0.70 YMR009W 2.3 1.9 0.5 1.9 1.9 1.2 1.9 1.4 3.4 2.2 2.1 0.6 2.3
1.9 0.6 2.3 2.7 2.5 0.75 YMR067C 0.9 0.9 1.1 0.4 1.1 1.4 1.2 1.1
4.0 3.5 1.1 1.1 2.2 1.5 1.4 1.0 1.0 1.0 0.49 YMR097C 1.5 1.0 0.7
1.6 0.7 1.2 1.5 1.5 2.1 2.1 1.5 1.2 2.1 2.1 1.7 1.7 1.4 1.8 0.59
YMR102C 1.0 2.9 1.1 0.8 1.2 6.3 1.8 1.0 1.7 2.6 1.5 2.4 4.4 0.7 0.7
1.1 2.4 2.8 0.94 YMR107W 5.0 3.9 1.7 18.4 1.1 1.0 1.2 1.3 6.0 17.1
3.0 0.8 1.8 8.1 1.9 12.0 1.3 8.1 0.49 YMR180C 1.2 0.9 1.0 1.3 1.0
2.4 1.7 1.8 1.8 2.2 0.7 1.2 3.1 1.7 1.0 1.8 1.4 1.7 0.57 YMR184W
1.3 5.4 1.0 1.1 0.8 0.9 1.6 1.9 2.1 0.9 1.5 1.7 2.3 1.5 1.1 1.2 1.4
2.0 0.68 YMR191W 1.3 2.4 1.9 1.6 1.5 1.0 2.0 1.1 2.2 3.5 2.3 1.8
3.4 1.5 2.7 1.7 1.2 2.1 0.99 YMR295C 1.7 1.0 1.2 1.6 1.4 1.9 1.3
1.0 1.0 0.8 1.2 1.1 2.3 1.3 0.9 1.9 2.1 3.4 3.43 YMR316W 3.2 2.9
1.1 1.9 1.1 0.7 2.0 1.6 2.1 3.0 1.5 1.9 2.9 1.3 0.5 1.3 6.9 6.4
1.25 YNL044W 1.3 0.9 2.3 1.3 1.2 0.9 0.9 1.8 0.8 0.8 1.1 1.0 3.1
1.2 2.4 1.0 3.1 3.4 2.56 YNL074C 0.9 1.3 1.8 1.2 1.3 1.7 1.1 0.6
1.5 2.0 1.3 0.9 2.3 0.6 1.0 0.7 1.1 1.3 0.68 YNL092W 1.3 1.4 2.4
1.8 0.9 1.2 1.6 0.9 2.3 1.5 0.7 1.1 2.3 1.2 2.7 1.3 1.7 1.6 0.16
YNL115C 0.7 1.8 1.6 1.4 0.8 9.1 2.4 0.8 2.6 1.9 1.1 0.8 2.5 1.0 1.6
3.1 1.6 2.6 0.80 YNL156C 1.1 1.2 0.9 1.3 1.6 1.3 1.9 1.2 2.4 1.9
1.4 0.9 2.0 1.4 1.8 2.1 1.8 1.9 1.85 YNL234W 1.1 1.1 0.6 1.8 1.7
1.3 1.2 1.3 2.6 3.3 1.3 1.1 2.5 1.5 1.4 2.6 1.0 1.0 0.49 YNL281W
1.0 1.3 2.0 1.4 1.7 0.9 1.2 1.2 2.8 1.6 1.6 0.7 2.0 1.2 1.2 0.5 0.9
0.9 1.79 YNL305C 0.9 2.2 2.7 1.4 1.3 1.1 1.7 0.7 2.9 2.1 1.8 1.1
2.6 1.3 1.6 2.5 1.7 1.6 1.35 YNR068C 1.2 1.5 2.3 2.6 1.7 0.4 1.8
1.1 6.7 14.4 1.1 1.3 3.7 1.8 1.0 1.4 1.0 1.0 0.24 YOL032W 1.3 0.8
2.0 1.3 1.4 2.1 1.4 1.5 4.5 3.0 1.4 1.0 2.3 1.3 0.9 2.4 1.7 1.8
0.77 YOL036W 0.8 0.9 1.3 0.8 1.2 1.2 1.0 0.8 3.1 2.8 2.2 1.0 2.5
1.0 2.0 1.0 1.1 0.9 0.48 YOL047C 1.4 1.1 1.1 2.5 1.4 1.5 1.3 1.1
0.6 2.3 0.9 0.8 2.0 1.2 12.3 1.3 1.5 1.0 0.19 YOL071W 1.3 2.0 1.7
2.0 0.9 1.7 2.0 1.6 4.4 2.3 4.3 1.0 2.5 2.5 0.7 4.6 1.3 2.0 1.08
YOL082W 1.0 1.6 1.6 2.1 1.5 1.8 2.5 1.1 3.4 2.0 1.6 1.0 2.4 1.4 1.0
2.4 1.6 2.5 0.60 YOL083W 1.1 2.3 1.2 2.8 1.4 4.5 3.1 1.3 2.7 2.3
1.3 1.2 2.3 1.4 1.0 3.8 1.4 3.2 0.41 YOL117W 1.0 1.1 0.5 1.4 1.7
2.0 1.6 1.1 1.3 4.1 1.0 0.9 2.2 1.7 1.1 2.2 1.3 1.4 0.21 YOL131W
1.0 1.5 0.6 1.0 1.5 1.1 1.3 1.1 8.4 8.1 1.4 0.9 3.1 2.3 1.4 0.7 1.1
0.9 0.15 YOL162W 2.0 6.9 1.7 1.4 0.9 1.2 2.0 1.6 12.0 6.8 4.3 1.4
3.8 1.4 0.6 0.9 1.2 0.9 0.26 YOR019W 2.9 1.2 0.8 4.7 1.4 1.3 2.8
1.1 3.5 7.1 1.7 1.0 2.2 1.4 0.7 2.6 1.7 2.8 0.40 YOR197W 0.8 1.0
1.1 1.4 0.6 1.3 0.9 0.9 0.8 0.7 1.0 1.0 2.1 0.7 1.7 1.0 1.5 1.5
1.30 YPL087W 1.0 5.1 3.0 7.3 0.6 4.3 4.2 1.0 1.0 2.2 2.5 1.8 4.4
1.2 1.3 1.8 2.1 2.7 1.49 YPL196W 1.3 1.6 1.3 1.7 1.5 2.0 2.4 1.2
10.9 2.8 1.7 0.9 2.1 1.6 0.7 4.3 1.4 2.3 0.92 YPL206C 1.0 2.9 1.4
1.9 0.7 1.8 1.2 1.0 1.7 1.1 1.5 0.8 2.5 1.1 0.8 1.2 1.4 1.9 1.22
YPL222W 0.9 3.5 0.8 1.3 1.2 2.2 1.1 0.7 7.4 3.4 1.2 1.3 3.0 1.1 0.9
2.2 1.1 0.9 0.26 YPR023C 1.2 1.4 1.2 0.8 1.1 1.4 1.2 0.9 4.4 2.8
1.7 0.9 2.0 0.9 0.8 1.4 1.0 1.1 0.81 YPR151C 2.3 2.0 1.5 4.1 1.3
1.6 4.4 1.4 3.0 9.5 1.4 0.9 2.0 1.4 0.7 2.8 1.3 1.4 0.16 YDL222C
0.9 1.1 1.5 3.9 1.0 1.4 1.0 0.7 1.9 1.0 2.6 1.0 2.2 1.3 7.1 6.5 0.9
1.3 0.50 YEL001C 1.0 1.0 1.4 0.7 0.9 1.3 1.1 1.2 2.0 1.2 1.2 1.1
0.9 1.3 3.0 1.2 0.7 1.3 2.81 YER106W 1.3 0.7 1.3 1.2 1.6 1.1 1.0
1.2 0.4 1.8 1.0 0.9 1.0 1.5 6.8 0.9 0.8 0.8 0.25 YIL023C 1.1 1.2
2.1 1.8 1.3 0.9 1.2 0.7 3.5 1.6 1.1 0.9 1.1 0.7 5.6 1.1 1.2 1.0
0.93 YJR054W 0.8 0.9 0.3 0.9 1.0 0.7 0.9 1.6 0.6 0.7 0.9 0.4 1.2
3.1 0.6 0.9 0.9 0.52 YKL086W 1.0 1.1 2.4 2.6 0.8 1.0 0.7 1.1 8.2
20.5 0.7 0.6 1.3 2.9 5.0 0.6 0.9 1.0 0.28 YKR091W 1.5 2.3 0.9 3.5
1.6 1.0 1.3 1.3 1.0 1.6 1.1 0.9 1.0 1.9 6.3 1.6 1.6 1.3 0.45
YLR194C 2.1 2.2 1.3 3.6 1.0 0.9 1.0 1.0 0.9 1.1 1.4 1.6 4.0 1.2 3.6
0.9 1.0 0.9 0.60 YMR095C 1.1 2.0 1.6 1.0 0.9 0.7 1.2 1.2 1.4 2.1
0.8 3.4 2.2 41.7 1.0 1.0 1.0 0.23 YAL053W 0.9 0.9 1.3 2.1 0.8 1.1
0.7 0.8 1.4 0.9 2.3 0.6 1.1 0.7 2.9 1.1 1.2 1.6 1.60 YDL072C 1.3
1.1 3.5 2.1 1.4 1.5 1.8 0.8 1.1 1.5 1.4 1.2 1.6 1.8 2.6 2.6 1.6 2.8
3.25 YDL204W 1.4 1.9 4.8 3.4 1.0 5.6 3.2 1.1 2.3 2.0 3.2 0.9 3.2
2.4 3.6 8.6 1.8 2.7 0.73 YDR391C 1.2 2.0 1.3 1.6 1.2 2.8 2.0 1.4
1.5 2.7 1.9 1.4 1.8 2.3 3.5 3.0 1.8 2.4 1.05 YIL024C 1.4 1.3 1.1
2.1 1.3 1.0 1.3 1.1 2.2 1.8 0.6 0.7 1.0 1.5 3.1 1.0 1.1 1.0 0.35
YIL117C 2.5 1.2 1.0 3.3 0.8 1.2 1.5 1.8 2.3 3.5 1.8 1.4 1.3 2.6 7.5
1.0 2.6 2.6 1.22 YJL108C 1.2 1.2 1.0 2.2 1.5 0.6 0.6 1.0 0.3 0.7
1.0 0.4 0.5 1.0 4.0 0.6 1.0 0.9 0.40 YJL149W 1.2 1.8 1.5 6.8 0.8
0.7 1.3 1.0 1.5 3.8 1.5 1.1 1.9 1.1 9.0 1.4 0.8 1.2 0.28 YJL186W
0.6 0.9 1.2 0.8 0.7 0.7 0.6 0.6 0.2 0.5 0.6 0.6 0.4 0.8 2.5 1.0 0.7
0.8 1.07 YNL190W 1.0 1.4 2.6 0.9 1.0 0.5 0.8 0.8 1.1 1.1 1.0 1.0
1.3 0.6 2.6 1.3 0.7 0.8 4.72 YNL208W 1.5 3.2 2.9 2.1 1.2 1.4 0.9
1.5 2.3 3.1 2.5 0.8 1.7 1.0 2.6 0.9 1.0 1.0 1.55 YNL300W 0.7 0.3
2.9 1.5 0.9 0.4 0.4 0.9 0.2 0.9 0.8 0.7 0.8 3.3 1.0 1.0 0.8 0.39
YNR064C 0.9 0.6 0.9 1.8 1.5 2.1 0.8 0.9 2.1 0.7 0.7 1.6 0.8 6.1 1.4
1.1 1.9 2.17 YOR248W 2.4 0.7 2.9 1.3 0.7 0.2 0.3 0.7 0.1 0.4 2.3
0.5 0.4 0.5 8.8 0.3 1.0 0.8 2.47 YPL052W 1.8 1.7 0.4 1.0 1.7 1.9
1.4 1.7 2.0 4.8 1.2 1.1 1.6 3.2 3.3 1.1 1.3 1.5 0.88 YPR079W 1.0
1.8 1.3 1.5 0.9 1.0 2.3 1.1 1.7 2.8 0.8 1.0 1.3 1.3 2.9 1.9 1.4 1.5
0.42 YAR028W 1.2 1.0 0.7 1.2 0.9 3.3 1.8 1.3 1.0 0.9 0.9 0.8 1.4
1.2 0.9 1.5 1.9 2.1 1.40 YDR031W 1.5 1.1 1.7 1.5 1.2 3.6 1.9 1.4
1.1 2.7 1.2 0.9 1.3 2.5 0.8 2.4 1.3 2.5 1.23 YDR486C 1.1 1.5 1.2
0.9 1.2 2.7 1.8 1.8 2.5 5.8 1.4 1.3 1.7 2.4 1.1 2.6 1.1 1.7 1.18
YER038C 1.2 1.4 0.6 1.2 1.4 2.8 1.5 1.1 0.7 2.5 0.6 0.9 2.2 1.3 0.8
1.6 1.2 1.4 0.51 YGL136C 1.1 1.0 1.2 1.1 1.0 3.1 0.7 1.1 1.3 1.0
1.4 1.1 1.1 2.3 0.9 1.4 1.3 1.1 0.64 YGR146C 1.6 2.0 2.0 2.0 0.9
4.1 2.7 1.4 0.8 3.8 0.9 1.4 1.7 1.3 1.4 1.8 1.3 0.9 0.75 YJL020C
0.7 1.2 0.8 0.8 1.0 2.1 1.3 0.6 1.3 1.0 0.6 0.7 1.6 1.2 1.4 0.8 2.0
1.3 0.95 YLR031W 1.3 1.0 0.7 1.3 1.3 3.0 1.5 0.9 0.9 1.4 0.7 1.0
1.6 1.5 0.7 1.6 1.2 1.2 0.30 YLR205C 1.2 5.1 0.7 1.3 1.3 4.4 9.0
1.7 1.5 5.7 0.4 1.3 1.4 2.4 2.5 2.3 2.0 1.4 0.29 YMR140W 1.0 0.9
1.2 0.7 1.1 17.1 4.3 0.8 1.8 2.3 0.7 0.9 1.6 1.2 1.4 2.8 1.4 2.0
0.54 YMR195W 1.7 3.1 1.2 2.2 1.1 2.6 1.1 1.0 0.2 0.7 1.1 0.9 0.7
1.3 0.6 2.5 1.6 2.2 1.28 YOR215C 1.5 1.3 0.7 1.8 1.8 2.6 2.6 1.7
2.1 1.3 1.6 1.1 1.3 1.7 0.8 3.3 1.3 2.9 2.08 YOR382W 0.7 7.6 3.3
0.5 1.2 13.1 28.4 2.0 1.1 12.8 2.5 2.8 1.7 0.4 2.1 4.3 1.9 1.9 0.79
YPL054W 4.2 5.3 4.9 3.1 1.1 2.3 1.8 1.3 2.5 9.2 1.9 1.3 1.5 1.4 1.0
1.3 1.5 1.4 0.25 YPR127W 1.1 1.4 1.0 1.6 1.1 3.2 1.7 1.2 1.9 2.4
1.6 0.9 1.3 1.4 0.4 2.4 1.3 1.2 0.65 YAR027W 1.8 1.0 1.3 1.4 1.2
2.3 2.2 1.3 2.3 1.7 1.7 1.2 2.6 1.3 1.2 2.8 2.0 4.7 2.15 YBL057C
1.1 0.9 0.6 1.0 1.3 2.2 1.1 1.4 1.6 1.2 0.9 1.0 1.0 1.6 1.0 1.1 1.2
1.2 1.88 YBR116C 0.9 4.8 2.4 2.3 1.1 2.8 1.5 1.1 9.0 8.7 3.1 1.1
2.0 2.7 1.7 9.9 0.9 1.0 0.45 YBR147W 2.2 1.1 1.5 3.2 1.2 2.2 1.2
1.9 0.9 3.6 4.0 1.3 1.2 1.1 2.1 6.0 1.3 1.9 0.63 YBR168W 0.9 0.8
1.0 1.3 1.6 3.5 1.6 1.0 1.1 1.7 0.8 0.9 1.9 1.8 0.9 1.0 1.1 1.5
0.56 YBR246W 1.0 0.8 1.7 0.6 1.1 3.1 1.1 0.9 0.5 0.9 0.8 0.9 1.1
1.3 0.9 1.8 1.4 1.7 0.82 YBR273C 0.8 0.6 0.6 1.3 1.9 2.2 1.4 1.4
2.2 2.0 0.6 0.8 2.1 0.9 0.8 0.9 1.4 1.4 1.33 YDR003W 2.0 2.4 1.6
1.5 1.8 1.8 1.8 1.1 6.6 3.6 1.8 0.8 1.5 1.2 1.0 1.8 1.4 2.0 0.95
YDR340W 1.2 1.4 0.7 0.8 1.1 1.9 2.3 1.3 1.4 2.4 1.4 0.9 1.3 2.0 1.4
1.0 1.1 1.6 1.90 YDR357C 1.3 1.5 0.3 1.3 2.0 1.9 2.2 1.7 1.0 0.9
1.1 0.6 1.0 1.4 0.5 2.2 1.3 1.7 0.73 YDR396W 0.7 1.3 0.6 0.7 1.4
2.0 1.5 1.4 0.3 1.2 1.0 1.2 0.6 1.4 0.9 1.3 1.1 1.3 0.63 YDR434W
0.8 0.8 1.5 1.2 1.0 2.2 1.4 0.9 0.8 1.2 0.8 0.9 1.2 0.9 1.3 0.8 1.2
1.5 1.53 YDR482C 1.1 0.9 0.7 1.1 1.5 1.7 1.2 1.0 0.9 0.8 0.8 0.8
1.1 1.0 0.5 1.7 1.6 1.2 0.85 YDR520C 0.9 2.1 0.9 0.6 1.3 2.3 1.2
1.0 0.8 0.7 0.6 1.2 1.4 1.0 1.3 0.9 1.1 1.0 0.46 YDR534C 0.8 4.8
1.8 0.9 1.0 2.1 9.7 1.0 0.6 7.5 1.7 1.5 1.8 0.7 4.2 1.0 0.6 1.0
0.34 YDR539W 0.7 2.0 1.1 1.0 1.8 2.1 2.3 1.3 0.7 1.2 1.3 1.2 1.3
1.1 1.5 1.6 1.2 1.4 0.61 YER044C 1.2 1.0 2.1 1.3 1.8 3.0 1.8 0.9
0.3 0.7 1.7 0.7 0.9 1.4 0.7 3.0 1.3 2.1 1.62 YER067W 4.0 1.9 5.2
6.0 1.1 2.1 4.9 2.1 1.8 3.8 2.2 1.1 1.2 1.7 0.5 3.5 1.5 3.0 1.57
YER080W 0.8 0.8 1.5 0.5 1.1 5.3 3.0 1.4 4.0 2.7 1.2 0.9 1.8 1.1 0.8
1.9 1.2 1.3 0.55 YGL113W 0.7 0.9 0.9 0.4 1.5 2.1 0.9 0.9 0.7 0.8
0.7 0.8 1.2 0.9 1.0 1.0 1.5 0.9 0.35 YGL242C 0.8 0.9 0.6 0.8 1.4
1.9 2.0 1.5 0.9 1.3 1.4 0.9 1.6 1.6 1.2 1.1 1.5 1.4 1.32 YGR052W
1.6 0.8 3.9 4.6 1.4 2.6 0.8 1.1 0.6 1.7 0.6 0.7 1.5 1.3 0.6 7.6 1.8
4.0 0.48 YGR106C 1.2 0.8 1.9 1.3 0.9 2.0 1.1 1.0 0.7 1.0 1.2 1.1
1.0 1.2 0.9 1.1 1.0 1.7 4.60 YGR111W 1.1 2.0 1.0 1.7 1.0 2.4 1.8
1.8 3.3 2.5 1.6 0.9 2.2 1.5 0.9 2.2 1.1 2.1 0.79 YHL023C 0.7 0.6
1.3 0.7 1.1 1.8 1.0 1.0 1.3 1.1 1.0 1.1 1.9 1.0 1.0 1.1 0.9 0.9
0.32 YHL048W 1.3 1.6 2.8 1.3 1.1 3.7 2.3 1.2 0.8 1.2 0.9 1.1 1.7
1.0 2.3 2.5 1.9 3.2 4.10
YIL007C 1.2 1.0 1.1 1.0 1.4 2.0 1.3 1.2 1.1 1.4 1.2 1.0 1.1 1.7 1.1
1.9 1.2 1.5 0.69 YIR016W 1.1 1.1 1.4 1.6 1.2 2.3 1.7 0.8 1.4 1.3
1.4 1.3 1.6 1.3 1.0 2.7 1.9 2.0 0.67 YIR043C 1.2 1.6 2.2 1.8 1.3
2.4 2.2 1.0 0.8 1.3 1.4 1.3 2.0 1.4 2.5 2.6 1.4 2.5 3.90 YJL012C
0.7 0.6 1.6 0.7 1.5 1.9 0.5 1.0 0.6 1.0 0.7 1.2 1.3 1.0 1.1 0.3 0.9
0.8 1.77 YJL083W 0.9 1.3 0.8 0.9 1.1 2.8 0.7 0.7 0.0 0.4 0.3 0.9
0.8 1.1 0.9 0.6 1.4 1.0 0.34 YJL131C 0.9 0.8 0.5 1.1 1.7 2.2 1.9
1.2 0.5 1.0 0.3 0.8 1.8 1.5 1.0 2.2 1.3 1.2 0.54 YJR061W 1.0 2.1
1.0 0.7 1.1 2.0 0.9 1.9 1.6 1.4 0.8 0.9 0.8 1.5 1.6 1.1 1.3 1.1
0.34 YJR161C 1.2 2.0 2.8 1.8 0.8 2.2 2.6 1.0 0.5 1.2 1.7 1.2 2.1
1.0 2.9 2.6 2.1 3.4 3.62 YKL175W 0.7 1.1 2.1 0.9 1.4 2.2 1.3 0.9
1.1 1.9 0.8 0.9 1.7 1.0 1.6 1.1 0.9 1.0 1.71 YKR070W 1.3 0.8 1.4
1.4 1.1 2.2 1.4 1.3 3.4 2.0 1.6 0.9 1.7 1.2 0.8 2.1 1.0 1.4 0.99
YLL023C 0.7 1.3 5.9 0.9 1.0 2.6 1.5 0.5 1.1 1.5 1.6 1.2 1.6 1.1 2.5
2.8 1.6 1.4 1.66 YLR023C 1.3 1.5 0.9 1.2 1.1 2.6 1.2 0.9 0.7 1.7
1.1 0.6 1.0 1.1 0.9 0.8 0.7 0.8 0.92 YLR225C 0.8 0.7 0.4 0.7 1.6
2.4 1.6 1.2 1.0 1.2 0.8 1.2 1.3 1.4 1.6 0.8 1.2 1.2 1.41 YLR241W
0.9 1.7 1.6 2.1 0.8 1.7 0.9 1.0 1.8 1.5 0.7 0.9 2.0 0.9 2.4 1.1 1.4
1.6 1.03 YLR252W 1.3 1.3 4.6 3.0 1.0 2.8 1.6 1.1 3.1 1.4 2.5 0.7
1.3 1.3 0.9 2.7 2.2 2.9 0.96 YLR270W 1.2 1.1 2.3 1.2 1.1 3.5 3.9
1.1 3.3 2.1 2.8 1.1 2.1 1.3 1.4 2.6 1.4 2.3 1.00 YML030W 1.3 0.8
0.8 1.4 1.9 3.0 2.1 1.4 0.8 0.8 1.2 0.7 1.0 1.3 0.6 2.7 1.2 1.3
1.35 YMR148W 1.0 1.0 1.6 0.9 1.2 2.9 0.8 0.6 1.0 0.8 1.0 0.5 1.0
1.0 0.7 1.4 1.1 0.9 0.28 YMR181C 1.3 1.6 1.8 1.1 1.2 2.1 2.0 0.9
1.9 1.4 1.7 1.4 2.8 1.0 1.4 2.8 1.1 2.0 0.79 YMR298W 1.3 1.3 2.9
0.8 1.5 2.3 1.3 1.1 2.4 2.6 1.7 0.9 1.0 2.0 2.0 1.7 1.4 1.6 1.37
YNL011C 1.1 1.5 0.8 0.9 0.9 2.9 2.9 1.5 3.8 1.6 1.4 0.6 1.2 1.2 0.8
3.1 1.2 1.8 0.68 YOL129W 1.0 1.1 2.5 1.2 1.6 2.2 1.6 0.7 1.2 1.2
0.7 0.8 1.8 1.5 1.0 1.9 2.6 2.4 2.61 YOR042W 0.6 1.4 0.7 0.7 1.3
2.1 1.1 0.9 2.1 1.2 0.9 0.8 1.3 1.2 1.1 1.1 1.4 1.1 0.54 YOR052C
1.5 1.3 0.5 2.4 2.3 2.4 1.4 1.4 1.4 1.3 0.8 1.0 2.6 1.6 1.2 1.3 1.2
2.3 2.64 YOR137C 1.1 1.0 0.9 1.2 1.3 2.1 1.6 0.6 0.7 0.7 0.9 0.8
1.6 0.9 1.4 1.0 1.6 1.5 0.78 YPL156C 1.4 1.4 0.9 2.9 1.2 2.4 3.2
1.2 0.5 2.8 0.9 1.5 1.7 1.6 0.8 2.4 1.6 1.9 0.70 YPL186C 1.6 1.7
1.4 4.5 1.3 3.2 3.2 1.9 2.4 1.5 3.7 1.0 1.4 2.0 0.7 6.2 1.2 2.9
0.60 YPL216W 0.7 0.8 1.3 0.9 0.9 1.8 0.8 0.9 1.8 1.9 0.9 0.9 1.1
1.2 1.0 1.1 1.1 0.9 0.47 YPR098C 1.6 2.6 1.7 1.9 2.0 3.0 2.9 1.1
1.4 1.7 1.9 0.9 1.2 1.8 0.9 2.9 2.2 2.2 1.10 YFL062W 1.3 2.7 1.7
2.4 1.6 1.8 3.5 1.1 0.6 1.2 2.2 1.1 1.6 1.1 1.6 2.7 2.1 3.0 3.43
YJL217W 0.6 0.7 3.1 2.5 0.7 1.7 3.2 4.5 0.7 1.7 4.6 0.7 0.5 0.7 0.8
5.1 1.4 2.5 2.19 YLR126C 0.9 1.5 0.4 0.8 1.3 1.7 3.4 1.8 1.3 3.4
1.3 1.4 1.6 1.4 1.4 1.4 1.3 1.2 0.61 YNL249C 1.3 1.7 0.3 1.5 1.2
0.7 2.3 1.7 2.6 1.7 1.4 1.0 1.4 1.3 0.9 1.3 1.1 1.1 0.56 YNL336W
1.2 1.0 3.4 1.3 1.3 1.4 2.5 0.9 0.7 1.9 0.8 1.1 1.3 1.1 1.9 2.8 2.0
3.1 3.74 YBR074W 0.7 1.3 0.9 0.8 1.3 1.5 2.2 0.7 0.4 0.5 0.5 1.0
1.2 1.5 0.8 1.3 1.4 1.0 0.52 YDL248W 1.1 1.7 2.8 1.7 1.5 2.0 2.5
1.1 0.9 1.4 1.4 1.2 2.0 0.9 1.8 1.9 1.6 2.4 4.35 YDR105C 0.7 1.1
2.3 1.0 0.8 1.4 2.1 0.8 2.3 1.7 1.4 0.9 1.8 1.1 0.9 1.4 1.1 1.4
1.09 YEL075C 1.1 1.1 0.7 1.0 1.1 1.4 1.9 0.7 0.6 0.7 0.7 1.1 1.7
1.9 0.8 1.2 1.4 1.1 1.19 YER046W 1.3 1.9 0.5 1.1 1.6 1.8 2.6 1.5
1.5 1.7 1.1 1.0 1.0 1.4 0.7 2.7 2.0 1.9 0.53 YER050C 1.3 0.9 0.5
2.3 2.2 1.0 2.2 1.5 1.4 1.6 1.4 0.7 1.0 2.1 1.0 2.1 1.0 1.8 1.40
YGL250W 1.1 1.4 1.9 1.8 1.6 1.4 2.0 1.1 1.5 1.2 2.4 0.7 1.2 1.0 1.1
2.3 1.2 1.9 0.45 YGR042W 1.5 1.1 1.2 2.0 1.5 2.2 2.2 1.8 1.3 3.2
1.6 1.1 1.6 2.2 1.4 2.6 1.3 1.9 0.79 YGR053C 1.3 0.7 0.6 2.7 2.1
1.9 3.4 1.5 4.5 2.2 1.6 0.7 1.2 1.7 0.7 2.7 1.5 2.4 0.39 YGR066C
1.6 2.5 1.3 2.5 1.2 1.7 2.1 1.3 2.3 5.0 2.6 0.8 1.2 1.9 0.7 2.6 1.0
1.1 0.17 YGR247W 0.8 1.1 0.8 1.0 1.0 0.9 1.8 0.9 1.1 1.1 1.1 0.6
0.8 1.0 0.4 1.2 1.0 1.0 0.45 YGR295C 1.0 1.6 2.8 2.0 0.9 1.9 2.8
1.1 0.5 1.2 1.1 1.1 1.9 1.0 2.4 2.4 1.6 2.8 4.78 YHL044W 0.9 1.3
1.5 1.4 0.7 1.9 2.0 1.4 1.1 1.9 0.7 1.2 1.6 1.7 1.1 3.9 0.8 1.2
0.45 YHR145C 1.5 1.6 0.6 0.9 1.4 1.3 2.1 1.6 0.8 2.4 2.0 0.9 1.5
1.8 1.3 1.1 1.3 1.1 1.70 YIL058W 2.0 0.9 1.4 0.5 1.3 1.4 2.2 0.8
1.1 1.0 0.0 0.6 1.0 2.0 0.9 2.1 1.4 1.3 0.39 YIL065C 1.0 1.3 0.8
1.6 1.9 1.6 2.0 1.4 3.8 2.1 1.1 0.9 1.8 1.7 0.8 2.4 2.1 1.4 0.94
YIL083C 0.8 1.0 0.9 0.8 1.2 1.4 2.2 1.0 1.0 1.1 1.2 1.0 1.0 1.0 0.9
1.4 0.9 1.1 0.76 YJL185C 0.9 1.0 1.9 1.6 1.0 1.4 2.3 1.0 0.9 1.2
1.2 0.8 1.0 1.4 1.6 2.3 1.0 1.1 0.30 YJL213W 0.8 1.1 0.2 1.2 1.5
2.6 2.1 1.2 1.3 1.5 0.7 0.7 1.0 0.8 2.8 3.6 2.1 2.8 0.33 YKR020W
1.1 1.8 0.9 1.6 1.0 4.5 2.2 1.5 1.9 2.8 1.0 0.8 1.7 1.4 1.2 2.5 1.3
2.0 0.44 YLL025W 0.8 1.3 1.8 0.8 1.1 1.5 1.9 1.0 1.5 2.0 1.4 1.0
1.3 1.0 1.2 1.7 1.0 0.9 0.40 YLR108C 3.2 1.8 4.7 1.8 1.9 1.3 2.6
2.0 7.4 10.4 2.6 0.8 1.9 3.4 1.2 2.3 1.0 1.5 0.39 YLR290C 1.3 1.2
0.8 1.9 2.1 1.7 2.3 1.1 1.2 1.1 1.5 0.8 1.0 1.3 0.8 3.2 1.3 2.4
1.49 YML068W 1.0 3.7 1.0 1.2 1.0 0.9 4.1 1.3 1.3 1.4 0.6 0.4 0.8
1.1 1.1 1.9 1.0 1.3 0.41 YMR178W 1.6 1.0 0.8 0.9 1.1 1.6 2.1 1.6
1.6 1.6 1.0 0.9 1.0 1.2 0.9 2.1 1.1 2.3 1.36 YNL122C 1.2 0.9 1.2
1.3 1.6 1.8 2.1 1.4 1.0 1.2 1.3 0.7 1.0 1.2 0.6 1.8 1.0 1.4 1.07
YNL285W 1.1 1.2 0.6 1.1 1.4 0.8 2.3 1.2 1.4 1.7 1.2 0.6 1.1 1.8 0.9
1.3 1.2 1.3 0.43 YNL293W 1.3 0.8 0.8 1.8 1.3 0.9 2.1 1.0 1.6 2.4
0.8 0.7 1.4 1.1 1.2 2.1 1.0 1.4 0.58 YNR061C 0.8 1.1 2.5 0.8 1.0
1.3 2.6 0.8 0.8 0.9 1.2 0.9 1.1 1.3 0.9 1.1 1.6 1.1 1.52 YOR220W
1.5 1.4 1.7 2.4 1.3 1.2 2.1 0.9 1.8 2.5 1.2 1.2 2.9 0.8 0.7 2.0 3.5
3.4 1.44 YPR077C 1.4 1.4 1.2 2.7 1.4 1.2 2.0 1.5 0.6 2.5 0.8 1.0
0.8 1.6 2.9 0.6 1.4 1.2 0.24 YPR147C 0.9 0.8 1.1 1.4 1.6 2.1 1.8
1.1 1.2 2.4 1.3 0.9 1.6 1.1 1.4 1.9 1.1 1.3 1.18 YEL041W 1.4 1.4
0.8 2.5 0.8 1.2 1.9 1.9 2.4 3.6 3.5 0.9 1.9 2.0 1.4 1.9 1.5 1.9
0.39 YKL187C 0.9 1.0 1.4 1.5 0.8 0.8 0.7 1.1 5.2 8.6 3.3 0.9 1.4
1.6 1.2 4.8 0.7 1.2 0.36 YBR285W 1.6 1.6 0.9 6.2 1.3 2.2 1.5 1.0
4.0 3.1 4.6 0.5 0.9 1.6 0.4 7.8 2.5 2.3 0.27 YBR292C 0.8 4.3 1.2
0.6 1.0 0.8 0.7 0.8 2.1 1.3 1.8 0.4 0.7 1.1 1.0 1.0 0.9 0.9 0.30
YDL123W 1.0 1.3 3.7 1.4 0.8 0.7 1.0 0.8 2.0 2.0 4.6 1.1 1.5 0.9 3.3
1.5 1.1 1.0 0.52 YDR056C 1.4 1.3 2.0 2.0 0.9 1.0 1.4 1.4 1.3 2.3
2.3 1.2 1.0 2.3 1.1 2.5 1.2 2.0 1.83 YDR132C 3.7 1.6 1.4 2.1 1.2
1.9 1.7 2.3 5.9 7.3 3.3 0.9 1.5 1.4 1.2 1.2 1.0 1.3 0.40 YDR154C
1.0 2.1 2.5 1.7 0.8 1.5 0.9 1.1 1.5 1.2 3.2 1.0 2.6 1.0 1.8 1.3 1.5
2.0 2.69 YDR295C 0.8 1.0 0.6 1.0 0.9 1.0 0.8 1.3 2.6 1.3 1.9 0.7
1.8 1.1 1.4 0.6 0.8 1.0 0.49 YDR494W 0.9 0.9 0.2 1.3 1.3 1.4 1.7
1.2 1.2 0.9 1.6 0.8 1.0 1.0 0.6 1.9 1.1 1.3 1.39 YEL072W 3.2 3.5
1.6 1.8 1.5 0.6 1.3 1.6 4.7 4.3 1.7 0.9 1.0 2.0 0.5 1.5 0.8 1.1
0.39 YER045C 1.6 2.1 1.2 1.0 0.9 0.8 1.1 1.4 2.0 1.5 2.3 0.8 1.2
1.3 1.4 1.6 1.1 1.1 0.34 YER181C 1.1 0.4 1.7 2.2 1.0 0.7 1.0 0.9
0.8 0.1 0.6 1.3 1.0 0.7 0.7 0.7 1.1 0.42 YGL114W 1.5 0.8 3.6 1.3
1.3 0.7 1.0 1.1 2.7 5.6 3.2 0.6 1.2 1.1 1.2 1.4 0.9 0.8 0.60
YGL193C 1.1 0.9 0.9 1.4 0.7 0.7 1.0 0.7 0.8 1.0 2.1 0.7 1.1 1.0 1.0
1.7 1.1 0.9 0.62 YGL204C 0.9 2.2 1.2 1.2 0.7 0.3 1.3 0.8 1.0 0.9
1.9 0.8 1.4 1.8 0.8 1.1 0.9 0.9 0.38 YGL259W 1.1 1.6 1.4 1.5 1.1
0.8 1.6 1.3 2.6 2.2 2.7 1.1 1.9 1.1 1.3 4.1 0.9 0.9 0.49 YIL060W
1.0 2.3 0.8 1.0 1.2 0.7 0.9 1.8 0.9 3.0 1.9 0.7 0.6 0.9 1.3 1.1 1.2
0.9 1.22 YJL036W 1.3 1.0 0.6 1.6 0.7 1.1 1.5 1.5 6.6 3.5 1.7 1.2
2.2 1.5 1.1 2.1 1.4 1.6 0.88 YJR085C 1.0 1.9 2.8 4.5 0.6 1.5 1.4
0.9 3.7 2.6 2.9 1.1 1.9 1.9 0.5 2.0 1.4 1.9 2.19 YKR071C 3.6 1.6
1.0 1.1 1.9 0.6 0.9 2.1 4.7 4.9 2.3 0.8 1.5 1.6 0.7 0.8 0.9 1.0
1.05 YLR145W 0.9 1.1 0.6 1.5 1.1 0.6 0.9 1.1 1.9 1.2 2.4 0.8 0.7
1.6 1.0 2.5 1.0 0.8 0.62 YLR156W 1.3 1.0 0.7 0.8 0.8 0.6 1.3 1.0
1.1 2.2 1.9 0.8 1.9 1.0 1.0 1.7 1.1 0.9 0.31 YLR280C 0.6 1.4 0.4
0.6 1.3 0.9 1.5 1.0 0.5 1.3 2.1 0.8 1.6 0.5 0.6 1.2 1.2 0.9 0.19
YLR311C 1.5 1.9 2.8 2.9 0.9 0.4 1.1 1.0 0.9 3.0 7.8 0.9 0.9 1.6 0.5
1.9 1.3 1.1 0.33 YMR034C 1.5 1.3 1.0 6.5 1.3 1.1 1.9 1.2 0.7 2.7
2.1 0.9 1.8 1.4 1.7 1.3 1.8 1.6 0.43 YNL240C 0.8 0.8 0.8 0.6 0.8
0.7 0.7 0.9 5.4 3.1 3.4 0.7 1.1 0.8 1.4 0.8 0.8 0.7 0.37 YNL260C
1.7 1.8 0.5 1.0 1.6 0.8 1.1 1.2 3.8 2.0 2.5 0.6 0.7 1.4 0.7 1.2 0.9
1.0 0.75 YNR074C 1.3 1.7 3.1 1.4 1.2 0.7 1.4 1.5 3.9 3.0 2.7 0.6
1.5 1.7 0.8 0.9 0.9 0.8 0.66 YOL084W 1.0 1.4 1.6 3.6 0.6 1.6 0.8
1.0 2.6 3.4 6.1 1.7 6.4 0.9 1.6 6.6 1.3 1.6 0.28 YOL159C 1.9 2.4
1.7 2.0 0.9 1.0 2.1 1.2 1.1 2.4 6.6 1.2 1.4 1.8 1.1 2.3 2.0 1.6
0.61 YOR228C 1.3 1.1 1.8 1.4 1.2 1.0 1.2 0.7 1.4 1.1 2.8 0.9 1.1
1.0 0.6 3.4 1.0 1.4 0.44 YOR255W 2.5 2.7 1.0 1.5 1.0 0.5 0.9 1.2
0.3 0.8 2.0 0.7 1.6 1.3 4.9 1.2 1.0 1.0 0.19 YBR047W 2.7 2.4 1.1
1.5 0.9 1.1 2.2 11.0 10.0 3.4 0.8 1.7 1.0 0.8 1.1 1.3 1.0 0.25
YER124C 0.5 17.3 0.7 1.2 1.4 2.1 1.0 1.8 0.4 1.4 1.5 0.6 0.7 0.5
0.5 1.5 0.9 1.1 2.22 YKR007W 0.8 0.9 0.8 0.9 1.1 1.6 1.5 1.9 1.1
1.8 1.3 0.8 0.9 1.2 1.2 1.1 0.8 0.9 0.73 YOR007C 1.1 3.3 1.4 0.9
1.1 1.2 0.4 2.1 5.6 2.5 1.8 0.7 0.7 0.8 1.3 1.0 1.2 0.8 2.26
YBL065W 1.2 2.9 1.0 3.5 1.1 0.7 1.0 1.9 20.8 4.2 1.3 0.7 1.8 1.9
3.1 0.9 1.1 0.9 0.15 YDL113C 1.0 1.4 1.2 1.2 1.0 1.2 2.2 1.7 3.8
3.0 1.1 1.3 1.5 1.2 1.2 1.7 1.2 1.5 0.58 YDR018C 1.5 1.3 3.3 2.6
1.3 1.5 1.4 1.4 2.3 4.4 1.4 1.1 1.8 1.7 1.0 2.6 0.9 1.2 0.22
YDR202C 1.1 1.2 1.1 1.3 1.3 1.7 1.6 1.4 4.8 2.4 1.3 0.8 1.2 2.0 0.5
2.8 1.0 1.6 0.79 YDR223W 1.3 4.6 2.0 1.9 1.1 1.4 1.0 1.0 2.7 4.6
1.4 1.0 1.5 1.2 1.2 3.5 0.9 1.0 0.29 YDR350C 0.9 1.5 0.4 1.3 1.3
1.3 1.5 0.9 2.8 2.5 0.9 0.9 1.0 1.1 1.6 1.3 1.4 1.2 0.53 YDR374C
1.9 2.9 1.5 0.8 1.3 1.1 0.9 1.8 10.4 3.9 1.4 1.0 2.5 4.0 2.0 1.3
1.0 1.0 0.36 YDR512C 1.8 4.3 2.5 2.3 0.7 2.1 2.0 1.6 3.6 4.0 1.8
1.1 1.9 2.7 1.1 3.0 1.3 2.0 0.82 YFR017C 1.1 1.4 4.4 4.4 1.2 1.2
1.3 0.8 1.0 7.1 3.1 1.8 1.7 1.3 1.4 3.7 0.9 1.1 0.49 YGL046W 1.6
1.2 1.5 1.4 0.9 1.2 1.0 1.2 0.8 4.5 1.5 1.1 1.6 0.9 2.0 1.2 1.5 1.3
0.42 YGL067W 1.6 1.3 1.7 1.1 0.6 1.0 1.1 1.2 1.0 2.3 1.7 0.9 3.7
1.6 0.7 1.0 0.9 1.1 0.63 YGL098W 1.2 0.8 0.5 1.7 0.8 0.7 1.2 1.3
1.2 2.4 1.3 0.8 0.8 1.1 0.7 1.3 1.1 1.5 0.77 YGL117W 2.3 0.6 0.5
2.0 0.9 0.9 1.3 1.9 0.5 5.8 1.4 1.5 1.4 2.0 1.4 0.6 2.1 1.1 1.05
YGL146C 0.9 1.0 1.1 3.3 1.3 1.2 1.3 1.2 0.9 3.2 1.3 0.9 1.1 1.2 1.1
2.2 1.0 1.0 0.43 YGR011W 1.1 1.5 1.0 1.3 0.9 1.1 1.8 1.4 7.4 9.4
2.3 0.8 1.6 3.9 1.8 1.6 0.9 1.0 0.40 YGR153W 1.5 0.9 1.0 1.1 1.6
0.9 1.4 1.8 2.7 2.5 1.0 0.7 1.1 1.9 1.3 1.1 1.3 1.7 0.39 YGR223C
1.8 1.2 1.5 1.3 1.3 1.2 1.2 1.4 6.2 3.8 1.9 0.8 1.8 1.6 1.2 1.8 1.1
1.8 0.66 YHR116W 0.9 1.2 0.9 2.1 1.6 1.5 1.8 1.1 1.5 2.7 0.9 0.8
1.9 1.4 1.2 1.9 0.9 1.5 0.60 YIL097W 1.2 1.0 1.3 1.2 1.2 2.0 1.6
1.7 4.9 3.4 1.4 1.1 1.4 1.4 1.2 2.1 1.1 1.7 0.52 YKL133C 1.3 12.7
2.4 2.0 1.0 1.7 3.2 1.5 4.1 5.9 1.4 1.3 1.4 1.6 1.7 3.8 1.2 2.4
0.35 YKL162C 1.3 1.0 1.9 0.9 1.1 1.7 1.4 1.5 6.7 4.7 1.6 1.1 1.1
1.9 1.6 2.0 0.8 1.1 0.25 YLL062C 6.5 6.7 4.6 1.1 0.8 0.9 0.7 1.8
14.9 5.4 1.7 0.6 1.4 1.7 1.6 1.0 0.9 0.9 0.29 YLR247C 0.8 1.5 1.0
1.0 1.2 1.2 1.2 1.3 2.5 2.9 1.6 1.0 1.8 1.0 1.4 1.4
1.2 1.3 0.48 YLR267W 0.9 1.7 1.3 1.4 1.2 1.3 1.4 1.4 1.1 4.6 1.7
0.8 1.5 2.3 0.7 3.6 1.2 2.8 0.24 YMR041C 1.2 2.8 1.4 1.2 1.1 0.5
0.5 1.4 6.5 6.0 1.6 1.0 1.1 0.6 0.5 0.3 0.8 0.4 0.84 YMR253C 0.9
1.7 2.0 1.3 0.8 1.7 2.3 1.0 1.5 2.8 1.0 0.5 1.2 1.3 0.9 1.3 1.2 1.4
0.42 YOR225W 1.1 2.8 1.4 1.0 1.3 0.7 0.8 0.8 0.8 3.3 1.2 0.5 0.6
2.2 0.7 0.6 0.9 0.9 0.26 YPL166W 1.0 1.4 1.4 1.4 1.2 0.7 1.8 1.2
1.5 3.1 1.4 0.8 1.4 0.8 1.2 2.3 1.1 1.6 0.39 YPL202C 1.1 1.6 1.0
0.7 1.9 1.4 1.6 1.1 1.8 3.5 1.0 0.7 1.1 0.9 1.0 1.2 1.1 1.0 0.56
YBR101C 1.3 2.2 1.7 1.1 1.2 0.8 0.6 1.0 6.9 3.0 1.3 0.7 1.6 0.7 0.5
0.3 0.9 1.0 1.83 YBR269C 1.2 5.7 2.2 1.1 1.3 1.8 1.3 0.8 2.7 2.6
1.2 1.0 1.3 1.4 0.4 1.6 1.5 1.6 0.58 YBR280C 1.2 1.0 2.7 2.0 1.3
1.6 1.7 1.0 5.3 1.9 1.3 1.3 2.8 1.3 1.0 3.2 1.1 1.7 0.33 YDL234C
1.9 0.9 0.5 1.4 1.0 1.1 1.9 1.3 4.6 2.1 1.5 0.9 3.5 0.7 1.0 2.5 2.3
3.6 0.94 YDL242W 1.3 1.3 1.6 1.5 1.3 0.7 1.1 0.5 4.0 4.1 1.3 1.0
1.0 1.0 1.2 1.3 0.9 1.0 0.38 YDR531W 0.8 0.9 0.7 1.0 2.0 1.2 1.6
1.4 2.9 1.5 1.3 0.9 1.4 1.2 0.9 1.2 1.5 1.2 1.32 YFR042W 1.5 1.2
1.9 1.9 1.8 0.8 1.6 1.0 2.8 2.6 1.7 1.1 1.9 1.7 1.4 1.4 1.7 1.7
1.17 YFR046C 1.1 2.3 1.1 1.6 1.2 1.0 1.0 1.5 5.8 1.5 1.0 0.9 1.1
1.4 0.9 1.3 1.2 1.2 0.29 YGL227W 1.0 0.8 0.9 0.7 1.2 1.1 1.2 1.0
2.4 1.9 1.1 0.8 1.0 1.3 0.9 1.5 1.1 1.3 0.59 YGR089W 0.8 0.8 0.9
0.5 1.1 1.2 0.9 0.8 4.0 1.4 0.9 0.7 0.8 1.1 0.8 0.9 0.9 1.1 0.50
YGR134W 1.1 1.5 0.5 1.3 1.3 1.0 1.0 1.5 2.4 1.9 0.9 0.7 1.5 1.1 1.1
0.7 0.9 0.8 0.33 YHR017W 0.8 1.0 1.3 1.3 1.4 1.1 1.5 1.5 2.9 1.7
1.5 1.0 1.2 1.2 0.8 2.5 1.1 1.7 0.90 YIL152W 1.1 1.3 1.0 1.7 1.0
0.8 1.2 1.0 3.1 1.8 0.9 1.1 1.4 1.7 0.9 1.5 1.1 1.0 0.81 YIL164C
1.2 1.2 1.0 1.2 1.0 1.1 2.0 1.2 4.2 3.0 1.0 1.0 1.8 2.0 0.9 2.5 1.4
1.4 0.54 YJR056C 1.0 2.4 0.8 1.2 0.9 0.5 0.9 1.2 3.5 1.4 0.8 0.8
0.9 1.4 1.6 1.3 0.9 1.1 0.44 YJR072C 0.7 2.5 1.0 0.8 1.1 0.7 0.8
1.3 3.1 1.6 0.9 1.0 1.1 1.2 0.6 0.9 0.8 0.8 0.78 YKL034W 0.8 1.4
1.0 0.9 1.1 1.9 1.4 0.7 2.6 3.7 1.2 1.0 1.9 1.0 1.6 1.5 1.3 1.2
0.41 YKR012C 0.7 1.4 1.0 1.0 1.2 1.4 1.0 1.0 3.9 1.2 0.8 0.7 1.5
1.4 1.2 0.9 1.0 0.9 0.61 YLR064W 1.1 1.1 2.9 1.3 0.8 1.2 0.8 1.0
3.3 2.1 1.6 0.7 1.6 1.4 1.5 1.0 0.9 1.0 1.49 YLR364W 3.3 8.0 1.2
1.5 1.3 1.0 1.0 1.1 8.3 1.3 1.5 0.7 1.0 3.0 1.9 1.0 1.0 0.9 0.37
YLR421C 1.1 1.3 0.9 1.2 0.9 2.6 1.5 1.5 4.5 3.3 1.2 0.9 1.6 1.6 1.6
1.9 1.2 1.8 2.07 YML118W 1.5 0.5 0.7 2.7 0.7 0.8 1.5 0.9 6.6 1.6
1.3 0.9 1.7 1.0 2.2 1.6 1.5 1.5 0.26 YMR114C 1.2 1.4 0.5 2.4 1.2
1.2 1.7 1.1 2.5 1.7 1.0 0.9 1.1 1.5 1.2 3.0 1.0 1.3 0.62 YMR115W
1.0 0.6 1.3 1.1 0.9 1.5 1.0 1.2 5.8 2.1 1.1 1.0 1.3 1.3 1.2 1.1 1.0
1.2 0.61 YMR258C 0.9 1.4 1.2 1.1 0.7 1.2 1.5 0.9 2.3 1.8 1.4 0.9
1.6 1.0 0.6 1.2 1.1 1.3 0.60 YNL181W 1.2 1.2 0.6 1.2 1.4 1.6 0.9
1.9 5.3 2.8 1.2 0.8 1.8 1.9 1.0 1.0 0.8 1.3 0.86 YNL191W 1.5 5.1
4.7 0.7 0.9 0.6 3.0 1.2 3.9 3.2 1.0 0.5 0.6 1.0 1.0 0.6 0.5 0.6
0.45 YNL212W 1.1 1.1 1.1 0.5 0.9 0.8 1.3 1.3 4.6 2.3 1.3 0.8 1.3
1.0 0.9 1.3 0.9 1.2 0.67 YNL265C 1.0 1.3 0.5 1.3 0.9 1.9 1.5 1.4
5.0 2.6 0.9 0.8 2.0 1.9 0.6 1.7 0.9 1.8 0.85 YOR088W 0.7 0.9 1.7
0.9 1.2 0.7 0.3 0.7 2.5 1.3 0.8 0.6 0.4 0.4 0.8 0.4 0.7 0.7 3.56
YOR155C 0.8 1.2 1.7 1.0 1.4 0.8 3.6 1.7 1.6 0.5 1.5 0.9 0.8 0.9
0.46 YPL151C 1.0 0.8 1.2 1.2 1.0 0.7 0.7 1.0 4.2 2.0 0.9 0.8 1.4
0.9 1.8 0.9 0.8 1.0 0.51 YPL249C 0.8 0.9 1.1 0.6 0.8 2.5 1.0 1.0
3.0 1.2 0.9 0.9 1.8 1.0 1.0 1.0 0.8 1.2 0.36 YPL260W 0.9 3.9 1.4
0.8 0.8 1.4 1.2 1.1 2.6 2.1 1.0 0.8 1.4 1.1 1.3 1.2 0.8 1.3 0.82
YPR061C 1.3 3.2 1.2 4.9 1.4 0.5 1.8 1.2 3.2 1.9 1.6 0.8 1.1 1.7 0.4
2.7 1.1 0.9 0.40 YPR093C 1.1 1.1 0.7 1.3 1.0 0.7 0.8 1.1 6.6 2.3
1.2 0.9 1.4 1.1 0.8 1.4 1.4 1.1 0.39 YPR158W 1.5 1.5 3.7 0.9 1.6
0.7 1.2 1.2 5.0 3.5 1.5 0.6 1.6 1.1 0.9 0.6 0.9 0.7 0.96 YPR169W
0.9 0.9 0.5 0.6 1.0 1.5 0.9 1.0 3.5 1.4 1.0 0.5 1.0 1.0 0.9 1.4 1.1
1.1 0.86 YPR174C 0.8 0.9 0.8 0.6 1.3 1.1 0.8 1.2 3.2 1.0 0.7 1.1
1.4 0.9 1.2 0.4 1.4 0.9 0.55 YAL014C 1.0 1.6 1.4 1.2 0.8 0.6 1.2
1.2 3.1 2.0 1.7 1.2 1.5 1.8 2.3 0.9 1.1 1.1 0.56 YAL017W 0.6 1.4
2.3 1.2 1.0 1.1 1.3 0.6 1.9 1.6 0.7 1.0 2.2 1.1 1.0 1.3 1.0 1.2
0.79 YAL049C 1.0 2.0 1.7 1.0 0.7 1.5 3.4 1.4 3.0 1.4 1.0 1.1 1.6
2.0 1.4 2.9 1.6 1.8 1.13 YBR013C 1.1 2.7 1.8 1.4 0.9 1.8 1.0 1.4
2.2 2.2 1.2 1.2 2.0 2.5 1.1 1.5 1.4 1.1 0.68 YBR051W 1.2 0.8 1.5
0.3 1.1 1.1 1.1 1.5 1.5 0.1 0.7 1.2 1.0 0.8 1.2 1.1 0.8 0.40
YBR063C 0.8 0.8 0.4 0.6 1.2 1.6 1.6 1.3 2.2 1.6 0.6 1.1 1.7 1.7 1.6
1.0 1.2 1.2 0.38 YBR129C 1.1 0.8 0.6 1.0 1.2 1.9 1.0 1.4 2.3 1.4
1.4 1.0 1.3 1.6 0.9 1.7 1.0 1.5 1.25 YBR255W 1.1 1.6 0.4 0.7 1.2
1.0 1.1 1.8 1.8 1.5 1.5 0.7 1.4 1.1 1.0 1.5 1.0 1.0 0.27 YBR281C
0.8 1.1 3.0 0.5 0.8 0.6 1.2 1.8 1.4 1.4 0.5 1.2 0.9 1.0 0.8 0.7 0.8
0.44 YCL044C 0.8 1.4 2.4 0.6 1.1 1.0 1.0 1.0 3.3 4.1 1.1 0.9 1.7
1.0 4.4 0.8 0.9 0.6 0.21 YDL089W 1.1 1.3 1.4 0.9 1.2 2.0 2.0 1.1
2.3 2.5 2.0 0.9 1.9 1.2 1.6 1.3 1.0 1.1 0.45 YDL173W 1.0 1.2 1.0
0.8 1.3 1.1 1.6 1.5 1.8 1.6 1.2 1.1 1.7 2.1 1.1 1.3 1.3 1.8 1.19
YDL193W 0.9 1.5 1.4 0.8 1.1 2.0 1.5 1.6 2.5 1.4 1.1 1.1 1.4 1.1 1.2
1.8 0.9 1.4 0.93 YDL233W 0.8 2.0 1.0 3.8 0.9 1.0 0.8 1.0 2.1 1.1
0.7 0.9 1.8 1.1 1.3 0.9 1.1 1.4 0.33 YDR071C 1.4 1.1 0.7 1.3 1.1
1.5 1.3 1.6 2.6 1.6 1.4 0.9 1.3 2.0 0.9 1.2 0.9 1.6 3.08 YDR078C
1.1 1.6 3.5 0.8 0.9 0.8 2.8 1.4 2.1 1.4 1.1 0.7 1.1 1.8 0.5 1.3 0.9
1.2 0.53 YDR109C 0.8 1.0 1.0 1.3 1.0 0.9 1.2 1.5 1.9 1.3 0.9 1.0
1.4 1.0 1.7 1.5 1.2 0.9 0.38 YDR140W 1.7 1.4 0.9 1.8 0.7 0.9 1.2
1.5 2.2 2.5 1.7 1.1 2.0 3.2 0.9 1.9 1.3 1.3 0.78 YDR221W 0.8 1.3
0.3 0.8 1.1 1.5 0.9 1.0 2.3 1.4 0.7 0.6 1.0 1.0 1.0 1.0 1.1 1.0
0.34 YDR271C 1.0 0.8 0.7 1.7 0.8 1.4 1.3 0.8 5.4 0.9 0.6 0.7 1.5
1.4 1.3 0.6 1.2 0.9 0.32 YDR316W 1.0 0.8 0.6 0.9 1.5 0.7 0.3 1.4
2.5 1.0 1.3 0.6 0.6 0.7 1.3 0.3 0.6 0.5 0.69 YDR338C 1.1 1.3 1.4
1.0 0.7 0.9 1.1 0.9 2.7 1.7 1.9 0.8 1.3 1.0 0.8 0.8 0.9 1.0 0.40
YDR421W 1.1 1.0 1.0 1.1 0.9 0.5 0.2 0.9 3.8 1.2 1.0 0.7 0.6 1.2 1.9
1.0 0.7 0.8 0.42 YDR425W 1.3 1.7 1.0 2.2 1.4 1.7 1.8 1.2 2.6 2.2
0.9 1.1 1.4 1.3 1.3 1.1 1.2 1.2 0.31 YDR485C 0.8 0.9 0.7 0.9 1.6
1.2 1.2 1.1 2.7 2.0 0.9 0.9 1.2 1.1 1.3 1.5 0.8 1.0 0.59 YDR504C
1.0 1.0 0.9 0.8 1.1 1.2 1.1 0.8 2.3 1.1 1.2 0.7 2.2 1.3 1.2 1.2 1.2
1.2 0.70 YEL044W 0.8 1.5 0.7 0.9 1.2 0.8 0.8 0.8 2.1 1.2 1.6 0.6
1.3 0.6 0.6 0.7 1.4 1.0 0.93 YER092W 1.3 1.3 1.2 1.1 1.2 1.5 1.3
1.1 1.9 1.6 0.9 0.9 1.2 1.2 1.0 1.9 1.4 1.7 1.13 YER182W 1.2 0.8
1.1 1.9 1.2 0.6 0.8 1.4 2.2 1.2 1.5 1.0 0.9 1.9 0.5 3.6 0.8 1.2
0.87 YFL042C 0.8 0.9 0.6 1.1 1.4 1.5 1.1 0.8 2.0 2.0 5.4 0.9 1.7
1.2 1.1 1.0 1.1 1.2 0.43 YFR056C 0.9 1.5 0.7 0.5 1.2 0.3 0.9 1.0
2.4 2.7 1.3 0.5 0.3 0.6 0.9 0.5 1.1 0.8 0.59 YGL041C 0.9 0.6 1.3
1.0 0.6 1.4 1.0 0.8 1.3 0.4 0.6 0.6 1.0 1.2 0.7 0.8 1.0 1.1 0.51
YGL045W 1.4 1.1 1.9 3.4 1.0 0.8 1.7 1.2 2.8 4.2 1.2 1.1 1.3 1.1 1.5
3.4 1.3 1.2 0.47 YGL057C 1.3 1.1 1.4 1.4 1.3 1.3 1.1 1.1 2.1 1.1
1.3 1.1 1.3 1.5 0.7 1.2 0.9 1.1 0.56 YGL183C 1.1 1.4 0.8 0.5 1.6
1.2 1.2 0.8 3.4 2.5 0.8 0.9 1.5 1.7 1.7 0.6 1.4 1.0 0.18 YGL223C
1.1 1.7 1.0 0.7 1.4 1.1 1.2 1.0 2.6 2.0 1.3 0.9 1.7 0.9 0.7 1.1 0.8
1.0 0.60 YGR156W 0.9 1.3 1.7 1.2 1.0 1.2 1.3 1.3 4.0 2.4 0.5 1.2
1.8 1.6 1.3 0.5 0.8 0.8 0.26 YGR198W 0.7 0.9 0.7 1.0 0.8 0.8 0.8
1.0 2.9 1.8 1.0 0.7 1.3 0.8 0.9 1.2 1.1 1.0 0.87 YGR210C 0.9 1.4
1.1 0.9 0.8 0.8 0.8 1.0 3.5 1.8 1.0 0.6 1.0 0.8 1.3 0.7 1.1 0.7
0.56 YGR211W 0.7 1.0 2.0 1.0 0.9 0.6 0.5 1.0 2.9 2.5 0.8 0.6 0.8
0.4 0.5 0.3 0.5 0.5 1.99 YGR237C 0.8 1.3 2.5 0.8 1.2 0.7 1.4 1.0
1.8 1.4 1.6 0.8 1.6 0.6 1.1 1.2 0.9 1.0 0.50 YGR250C 1.3 1.4 1.4
1.5 1.4 1.6 1.2 1.1 2.4 2.8 1.6 0.6 1.7 1.3 1.2 1.2 1.3 2.1 1.21
YGR266W 0.7 0.5 1.0 0.9 0.8 1.2 0.9 0.9 2.0 1.1 1.2 0.6 1.1 0.8 1.1
1.3 0.7 1.0 0.59 YGR277C 1.0 1.9 1.1 0.8 0.8 0.8 1.9 1.3 2.8 1.5
1.2 0.9 1.6 1.5 0.9 1.0 1.3 1.1 0.81 YHL021C 1.6 3.9 5.9 3.2 0.9
1.4 2.7 1.0 2.7 1.1 1.4 1.1 2.6 1.1 1.2 2.4 1.3 3.6 1.27 YHL037C
1.2 1.4 0.9 1.0 0.7 1.0 1.1 0.4 1.1 1.0 0.6 1.0 0.9 0.8 0.7 0.9 0.9
0.28 YHR083W 1.0 0.9 1.4 1.3 0.9 0.9 1.0 1.0 2.0 2.1 1.3 0.9 1.1
1.6 1.3 2.4 0.8 1.0 0.90 YHR134W 1.1 0.7 0.4 1.1 1.1 2.0 1.3 1.2
3.5 1.5 0.7 1.0 1.2 1.6 1.0 1.2 1.3 1.3 0.81 YHR180W 1.5 0.7 1.1
1.5 0.9 1.1 1.1 1.2 4.8 3.5 1.4 0.7 1.3 1.5 0.8 1.3 0.8 1.0 0.36
YIL108W 1.0 1.7 2.2 0.7 1.3 0.6 0.9 0.8 2.4 2.0 1.2 0.7 1.3 1.0 1.8
0.7 1.2 0.7 0.51 YIL165C 1.2 2.3 0.9 1.6 1.6 0.8 1.5 1.1 3.2 3.4
1.1 0.9 1.5 1.3 0.8 1.9 1.4 1.3 0.74 YJL032W 1.1 1.0 0.8 0.9 0.9
0.6 0.9 1.3 3.3 2.0 1.8 0.5 1.4 1.6 1.0 1.2 1.1 1.1 0.33 YJL049W
1.3 0.8 0.5 1.8 1.6 1.5 1.2 1.5 2.0 1.9 1.5 0.8 0.9 1.8 0.8 1.6 0.9
1.1 0.75 YJR044C 1.1 1.2 5.1 1.0 1.0 1.5 2.0 1.0 2.2 1.6 1.9 0.7
2.0 1.3 1.6 2.7 1.8 1.6 1.18 YKL059C 0.8 1.0 0.9 0.7 1.3 0.9 1.0
1.0 2.6 1.2 0.9 0.9 1.3 1.1 1.1 0.8 1.1 0.9 0.53 YKL090W 1.0 0.9
1.0 1.2 1.1 1.0 1.1 1.2 3.9 1.6 2.3 0.6 0.8 1.4 0.8 1.6 0.7 1.0
0.37 YKL094W 1.2 1.6 1.2 1.9 0.9 1.0 1.1 1.3 3.1 1.8 1.3 0.9 1.7
1.3 1.0 2.0 1.2 1.9 1.60 YLR097C 1.1 1.5 1.0 1.6 1.6 1.7 1.8 1.4
2.2 1.1 1.7 0.8 1.1 1.7 0.9 2.5 1.1 1.7 0.76 YLR226W 1.0 1.8 0.3
1.0 1.7 1.1 1.9 1.3 2.1 1.4 0.8 0.7 0.7 1.1 1.3 0.9 1.1 1.0 0.56
YLR392C 1.1 0.9 0.8 1.9 1.0 1.2 1.0 1.3 2.4 2.1 1.4 0.6 1.4 1.1 0.5
2.1 0.8 1.6 0.46 YLR427W 0.6 1.0 0.2 0.5 1.6 1.0 1.2 1.1 2.1 1.3
0.8 0.9 2.5 0.8 0.8 1.3 1.0 1.0 0.49 YML013W 0.8 1.0 0.4 0.6 1.3
0.6 1.3 0.6 2.1 1.2 1.1 0.9 1.2 1.1 2.2 1.3 1.1 0.8 0.27 YML029W
0.6 1.5 1.3 1.0 1.2 1.6 1.1 0.9 2.3 1.8 1.2 1.1 2.0 1.6 0.8 1.1 1.2
1.0 0.46 YML041C 1.2 1.0 0.6 1.0 1.3 1.9 1.4 1.8 3.0 1.5 0.9 0.8
1.2 2.2 1.0 1.4 1.3 1.3 0.59 YML079W 1.0 1.7 1.1 1.5 0.8 1.4 1.2
1.2 1.9 1.4 1.2 1.1 1.6 1.4 0.3 2.0 1.4 1.4 1.18 YMR068W 0.9 0.7
0.8 1.5 1.6 1.1 1.5 0.8 2.4 1.4 1.1 0.7 1.4 1.1 2.2 0.8 1.3 1.1
0.24 YMR160W 0.8 1.3 1.2 1.2 1.4 2.2 1.0 0.9 2.2 1.8 1.0 1.0 1.6
1.1 1.5 1.4 0.9 1.3 0.37 YNL026W 0.7 1.0 1.3 0.8 1.4 1.1 1.5 1.0
2.7 1.8 1.1 0.9 1.7 0.8 0.8 1.5 1.0 1.4 0.86 YNL063W 0.9 1.9 0.9
1.4 1.1 1.1 1.4 1.5 3.0 1.8 1.1 1.0 1.5 1.1 0.7 1.8 0.9 1.0 0.54
YNL176C 1.1 1.3 2.9 1.0 0.8 0.7 0.7 0.9 2.4 2.1 1.2 0.6 0.6 0.9 0.8
1.3 0.6 0.8 0.66 YNL194C 1.6 0.7 2.0 15.2 0.7 0.7 1.5 0.9 2.2 6.4
17.1 0.5 1.5 3.0 0.5 4.3 0.8 2.4 0.34 YNL253W 1.3 1.3 0.6 1.0 1.5
1.3 1.3 1.1 2.8 2.6 0.8 0.8 1.1 1.4 0.5 1.1 1.1 1.2 0.54 YNL276C
1.3 13.1 1.9 0.3 1.1 1.3 0.9 0.7 3.1 1.3 0.7 0.9 1.5 1.5 0.5 0.8
1.1 0.8 0.22 YNR051C 0.7 0.5 1.1 0.6 1.3 1.8 1.3 0.7 2.4 1.4 1.5
0.9 2.1 1.0 1.2 0.6 0.7 0.8 1.58 YOR022C 1.3 1.1 1.1 1.2 1.4 1.2
1.6 1.2 2.0 1.4 1.7 0.8 1.7 1.0 0.8 1.8 1.1 1.1 0.36 YOR087W 0.7
1.0 1.8 1.3 0.8 0.3 0.9 0.8 2.8 1.3 1.3 0.8 1.2 0.9 0.8 1.2 0.8 1.1
0.61 YOR138C 0.8 1.5 0.7 0.8 0.8 1.0 1.1 0.8 2.1 3.7 0.7 0.9 1.8
0.9 1.0 1.1 1.1 1.1 0.47 YOR267C 0.8 0.7 1.0 0.9 1.2 1.6 0.9 0.7
2.4 2.2 0.4 0.9 1.4 0.9 1.3 0.8 1.3 1.0 0.58 YPL005W 1.0 1.0 1.0
1.0 1.4 0.8 2.0 1.0 2.6 2.8 1.1 0.7 1.2 1.0 1.2 1.6 1.2 1.1 0.32
YPL150W 0.7 0.9 1.6 0.9 1.0 0.6 1.2 1.1 3.1 2.0 1.1 1.0 2.1 1.0 1.1
1.2 1.4 1.1 0.47 YPL152W 1.4 1.1 1.4 1.8 1.4 1.2 1.3 1.1 3.6 2.7
1.4 0.9 1.4 1.2 2.3 1.4
1.2 1.9 0.42 YPL168W 1.1 1.5 0.5 1.4 1.0 0.8 1.2 1.2 2.1 1.6 0.7
0.7 1.0 1.0 0.8 1.3 1.1 1.2 0.41 YPL180W 0.9 2.0 0.7 0.6 1.2 1.5
1.0 1.0 1.9 1.8 1.0 0.8 1.5 1.0 0.7 1.0 1.0 0.9 0.30 YPL188W 1.3
1.2 2.9 1.0 0.9 0.6 1.3 1.6 2.5 2.6 1.0 0.6 0.9 1.4 0.8 1.7 0.7 0.9
0.55 YPR049C 1.0 2.5 1.5 1.0 0.7 1.2 1.1 1.1 2.4 2.1 0.9 0.9 1.6
1.4 1.5 1.7 1.0 1.1 0.34 YPR148C 1.1 1.2 0.8 1.3 0.9 1.0 1.6 1.5
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1.2 1.0 1.7 1.2 1.0 2.1 1.3 1.9 0.8 1.3 1.6 1.5 1.9 1.1 1.4 0.45
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1.1 0.9 0.9 0.21 YAR064W 2.1 0.9 0.9 2.8 0.8 0.5 1.1 1.1 0.0 0.7
0.7 0.8 1.1 1.1 1.9 1.0 0.9 0.9 0.30 YBR012C 2.5 1.7 1.3 0.8 0.9
1.8 1.5 1.1 1.4 2.6 0.7 1.0 2.1 0.9 1.1 1.3 1.4 1.2 0.46 YBR287W
1.7 1.9 3.1 2.4 1.3 1.4 1.1 1.0 1.2 1.6 2.0 1.2 3.4 0.8 1.3 1.6 3.2
1.9 2.73 YDR250C 1.9 1.4 0.9 3.0 1.0 0.4 1.0 1.1 0.5 0.6 0.8 1.2
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1.8 2.4 1.6 0.8 1.1 2.0 1.6 1.0 1.3 0.9 0.26 YNL058C 2.0 1.0 2.1
1.7 1.0 0.4 0.7 0.3 0.7 1.0 1.0 0.6 0.8 2.2 0.9 0.8 1.0 0.60
YJR030C 0.7 4.4 0.9 1.2 0.7 0.6 0.7 0.9 0.4 0.5 0.8 0.9 0.7 1.0 0.8
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1.0 1.1 1.0 0.7 0.5 0.6 0.7 0.4 0.6 0.7 0.9 0.7 0.5 0.7 0.8 0.78
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1.94 YNL200C 1.0 3.0 3.6 2.0 1.0 0.4 1.2 0.7 1.9 1.2 3.1 0.9 1.1
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1.0 1.5 0.7 0.6 0.8 0.9 1.1 0.9 1.1 1.1 0.79 YMR071C 1.0 2.0 1.1
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1.3 1.5 1.0 1.1 0.6 1.0 1.0 0.85 YIL127C 1.1 4.8 0.2 1.2 1.0 0.4
0.6 1.2 0.3 0.5 0.9 0.7 0.4 1.3 0.7 0.2 0.7 0.6 1.57 YDR281C 2.1
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0.6 1.1 1.2 1.1 0.7 0.4 0.9 0.9 1.0 1.0 0.8 0.9 0.9 0.29 YBL044W
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1.3 0.9 1.2 1.1 1.0 0.8 0.9 1.2 1.4 0.8 1.3 0.9 0.9 1.3 1.0 1.1
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0.9 1.1 0.9 0.8 7.9 0.5 0.9 0.6 1.2 0.8 1.5 0.9 0.8 0.6 0.33
YBR162C 0.6 0.5 3.1 0.8 1.3 0.6 0.3 0.8 0.1 0.4 0.8 0.7 0.7 0.5 1.9
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2.6 1.0 1.5 1.2 2.3 2.6 1.2 1.6 1.94 YDR133C 0.9 1.1 2.9 2.0 1.2
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1.40 YJL097W 1.0 1.1 3.7 1.6 0.9 1.6 1.0 0.8 0.3 0.7 1.5 1.0 0.7
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1.3 1.1 1.8 0.8 1.2 0.7 1.5 0.9 1.5 1.4 1.07 YKL100C 0.7 1.1 5.0
1.6 0.6 1.8 1.2 0.7 1.3 1.3 1.6 0.9 1.3 1.0 1.7 2.0 0.7 1.5 1.14
YLR339C 0.7 0.8 3.1 0.8 1.3 0.4 0.4 0.5 0.4 1.6 0.6 0.1 0.5 1.0 0.5
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1.8 1.6 0.5 0.6 0.4 1.1 0.6 0.2 0.8 0.9 0.7 0.9 0.9 1.0 0.5 0.8 0.8
0.58 YBR096W 1.1 1.5 2.8 1.6 0.9 1.7 1.9 1.0 1.2 1.6 1.2 0.9 1.9
1.7 1.1 1.1 1.1 1.5 1.43 YBR100W 1.0 1.5 4.8 1.1 0.9 0.5 1.0 0.9
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1.2 1.7 1.1 0.8 0.9 0.6 1.0 1.0 1.0 0.9 1.9 1.2 0.8 1.4 0.9 0.72
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1.0 1.2 1.0 0.63 YDL015C 0.9 0.7 3.6 1.1 1.2 2.5 1.1 0.9 0.7 1.1
0.8 1.0 0.9 1.1 1.1 2.1 1.0 1.5 2.99 YDL023C 0.8 1.6 2.4 1.1 0.6
0.3 1.5 0.7 0.7 1.5 3.5 0.9 1.4 0.7 0.6 0.9 0.8 1.1 0.78 YDL086W
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0.5 0.9 1.5 2.8 0.9 0.9 3.47 YDR359C 0.8 0.7 1.7 1.9 1.3 0.8 1.0
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2.7 1.1 1.0 0.7 0.3 0.7 0.6 0.4 1.2 0.6 0.4 1.0 0.6 0.9 0.9 0.9
2.96 YGR022C 1.3 1.1 1.7 2.2 1.1 1.3 0.9 0.9 0.2 0.4 0.7 1.2 1.1
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0.7 1.3 0.5 0.6 1.0 1.2 1.4 1.0 1.2 2.19 YGR107W 1.0 0.8 1.7 0.9
1.1 0.8 1.0 0.9 0.1 0.0 0.6 0.6 0.9 1.0 1.1 0.8 1.2 0.8 0.43
YHL005C 0.9 2.7 2.7 0.2 1.2 1.1 0.8 0.9 0.9 0.7 0.7 1.0 0.7 0.7 1.0
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0.8 0.8 1.4 1.7 1.1 1.3 1.31 YHR143W 0.5 0.9 4.9 1.0 1.2 2.1 0.5
1.5 0.2 0.7 1.2 0.5 0.5 0.8 0.3 0.9 0.9 0.7 3.58 YIL157C 1.1 1.3
2.1 1.7 0.8 1.3 1.2 1.0 0.9 0.9 1.3 0.8 1.0 1.0 0.5 1.8 1.1 1.5
1.46 YIR041W 1.6 1.0 2.4 1.4 1.3 1.0 1.6 0.9 1.5 2.5 1.2 1.3 1.1
1.1 1.3 1.3 1.1 0.9 0.66 YJL016W 1.3 1.6 2.7 1.3 1.4 1.5 1.4 0.9
0.6 0.9 1.3 0.9 1.3 1.6 1.1 2.5 1.2 1.5 0.88 YJR018W 0.8 1.2 1.8
0.7 1.1 1.0 0.9 0.7 0.4 0.7 0.9 0.8 1.5 0.9 1.4 0.8 1.0 0.7 0.35
YKL147C 1.0 1.3 1.9 0.9 0.8 0.7 0.8 0.7 1.0 0.5 0.3 0.9 1.0 1.0 0.7
1.1 0.9 0.9 0.28 YKL169C 1.0 1.0 1.6 1.8 0.8 1.2 1.5 1.2 0.3 0.5
0.7 1.0 1.3 0.8 2.6 0.9 1.1 0.45 YKR033C 0.9 1.2 2.1 1.0 1.0 0.6
1.0 1.0 0.1 1.4 0.3 0.4 0.9 0.9 1.1 0.6 1.0 0.9 0.28 YLL064C 0.8
1.7 1.7 1.9 0.9 1.7 1.1 0.9 1.1 2.5 1.0 1.1 1.3 1.1 1.2 1.6 1.2 1.0
0.68 YLR041W 0.8 1.2 2.2 1.5 1.6 0.5 1.2 0.6 0.4 1.1 0.4 0.3 0.5
1.3 0.5 0.7 0.9 0.69 YLR177W 0.8 1.2 1.8 2.2 0.8 1.1 1.3 0.9 1.0
2.3 0.9 1.1 1.5 1.0 0.5 1.3 1.1 1.5 1.25 YMR007W 1.1 0.9 2.0 0.7
1.3 1.7 3.1 0.7 0.1 0.9 0.8 1.3 1.2 1.8 1.1 2.5 1.0 0.30 YMR156C
1.0 0.9 2.7 1.7 1.2 1.4 1.4 0.9 0.6 1.3 1.1 0.7 1.0 1.2 0.7 1.3 1.2
1.1 0.40 YMR215W 0.8 0.5 2.1 1.2 1.1 0.3 0.3 0.5 0.1 0.2 1.1 0.4
0.2 0.5 0.7 0.2 0.7 0.7 1.59 YNL195C 0.9 1.1 3.5 4.7 0.9 0.8 1.1
0.9 2.6 11.7 2.9 0.6 1.6 1.5 1.4 6.4 0.8 0.9 0.32 YOL073C 0.7 0.9
2.5 0.6 1.1 1.2 1.3 0.7 1.9 1.1 1.7 0.8 1.6 0.8 1.6 1.7 1.2 1.2
0.54 YOR129C 0.6 0.8 3.3 0.8 1.3 0.4 0.4 0.6 0.2 0.4 1.1 0.6 0.2
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1.0 1.7 4.6 0.5 0.7 0.9 1.4 2.0 0.7 1.2 0.82 YPL004C 0.7 1.2 3.7
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1.1 0.7 1.1 1.1 0.6 2.5 0.9 1.2 0.25 YPR063C 1.0 0.8 2.6 0.8 1.2
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1.4 1.3 0.9 1.4 1.1 1.1 0.57 YGL059W 1.3 1.5 0.9 3.1 0.7 0.7 1.0
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0.51 YAL037W 1.6 0.9 1.1 3.5 1.2 1.1 1.0 1.3 0.6 1.9 0.5 0.8 1.1
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0.51 YEL057C 1.1 0.6 1.3 2.4 1.0 0.9 1.1 1.2 1.2 1.9 0.7 0.8 1.5
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1.1 0.8 1.5 1.0 1.0 1.26 YGL214W 0.9 1.0 1.2 2.6 1.2 0.9 0.8 0.9
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1.2 1.2 0.7 7.9
1.5 1.9 0.30 YHL042W 1.2 0.8 1.3 51.1 1.0 0.7 1.2 1.0 0.8 1.8 0.7
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1.1 0.8 5.4 1.4 0.7 1.1 0.8 0.8 1.7 1.1 0.5 1.0 1.1 0.9 1.1 1.3 1.0
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1.5 0.8 11.1 1.1 3.6 0.26 YIL089W 1.3 1.3 0.7 3.9 1.6 1.6 1.6 1.1
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1.5 0.8 1.1 0.7 0.3 0.6 0.7 1.0 0.8 0.6 1.2 1.0 0.18 YIL113W 0.9
1.0 0.9 2.6 0.6 1.0 1.9 0.7 1.9 2.2 2.5 0.8 1.3 1.2 0.9 1.6 1.4 1.3
0.48 YIL122W 1.2 1.1 1.1 2.1 0.9 0.2 0.8 0.7 0.4 0.8 2.1 1.0 0.7
1.0 1.6 1.4 0.9 0.9 0.35 YJL100W 1.4 2.0 0.9 2.3 1.3 1.1 1.2 1.2
1.8 2.7 1.5 0.9 1.4 1.2 1.2 1.4 1.5 1.1 0.38 YJL169W 0.8 1.1 1.5
2.8 1.4 0.8 0.9 0.7 0.3 0.5 0.4 0.5 0.7 1.0 0.9 0.6 1.1 0.9 0.35
YJL199C 1.1 0.7 0.9 4.5 1.0 1.7 1.0 1.0 1.0 1.6 1.0 0.8 0.9 1.9 0.9
3.7 1.0 1.0 0.59 YJR039W 0.9 0.6 0.8 3.0 1.8 1.0 1.6 1.2 1.8 1.6
1.8 0.7 1.5 0.6 1.2 1.5 1.3 1.3 0.24 YJR101W 0.8 0.6 0.7 2.9 1.8
0.9 1.5 1.1 0.4 0.8 1.2 0.5 0.5 0.9 0.5 1.2 1.0 1.1 2.04 YKL061W
1.3 0.7 0.7 1.8 0.8 1.0 0.9 1.2 0.8 1.0 1.1 0.7 0.8 1.2 0.6 1.5 1.3
1.6 0.92 YKL121W 0.9 7.8 0.8 11.8 1.6 1.2 1.7 1.0 0.8 0.9 1.6 0.8
1.0 1.2 0.8 1.6 1.6 1.1 0.31 YKL160W 1.5 1.0 0.4 1.8 1.1 1.5 1.5
2.1 1.3 1.9 1.4 0.9 1.6 1.5 0.8 1.6 1.5 2.2 2.19 YLR016C 0.7 1.3
0.5 2.0 1.5 0.8 1.1 1.2 0.8 1.1 1.0 0.7 0.8 0.9 0.7 1.3 1.0 1.3
1.15 YLR030W 1.4 1.5 0.8 2.5 1.2 1.5 1.5 0.9 0.3 2.7 0.2 0.8 1.5
1.2 0.6 2.1 1.0 1.0 0.29 YLR036C 1.3 0.8 0.7 2.0 1.5 1.3 1.7 1.2
0.4 1.6 0.8 0.7 0.7 1.3 0.6 1.4 1.0 1.4 1.07 YLR112W 1.1 0.9 1.1
1.7 1.3 1.3 1.0 0.7 0.7 0.5 0.5 0.7 0.8 0.4 0.4 1.0 0.8 0.39
YLR125W 1.4 2.0 0.5 3.1 1.8 0.7 1.3 1.2 0.5 1.7 1.1 0.5 0.8 1.3 0.7
1.6 1.2 1.2 0.29 YLR128W 1.3 1.4 0.8 1.8 1.3 1.3 1.1 0.8 1.7 1.4
0.7 1.2 1.4 0.9 1.5 1.2 1.2 0.25 YLR204W 1.1 0.9 0.5 2.1 2.0 1.5
2.0 1.3 1.4 1.6 1.6 0.8 1.1 1.8 1.0 2.5 1.2 1.3 1.26 YLR211C 1.3
1.0 0.8 7.7 1.7 1.2 1.8 1.1 0.9 1.2 0.8 0.7 1.1 1.2 3.6 1.9 1.3 1.3
0.35 YLR257W 1.5 1.0 0.7 2.4 1.4 1.2 0.8 1.3 1.0 1.1 1.2 1.0 1.0
0.9 1.0 1.7 1.8 2.6 5.20 YLR326W 1.2 1.0 1.5 2.2 1.3 0.4 1.2 0.9
0.7 1.5 6.6 0.5 0.4 1.1 0.7 0.9 0.8 1.0 0.33 YLR334C 1.2 1.1 1.1
2.3 1.8 1.0 1.4 0.9 1.0 0.8 0.8 0.8 0.9 2.2 2.5 0.7 0.8 1.0 0.30
YLR408C 1.3 2.3 0.6 2.3 1.4 1.0 1.0 1.4 0.9 1.1 0.7 0.8 1.1 2.1 0.9
1.1 1.2 1.2 0.79 YLR414C 1.5 1.6 1.4 4.8 1.3 0.6 0.7 0.9 0.2 1.2
1.2 0.6 1.0 1.0 2.1 0.9 3.9 3.6 2.21 YLR444C 0.9 0.8 1.7 5.9 0.7
0.7 0.9 0.9 0.2 0.2 1.1 0.6 0.5 1.1 1.3 0.7 0.9 0.9 0.50 YML050W
1.5 1.2 1.3 2.1 0.8 0.5 0.9 1.1 1.3 1.6 1.2 0.8 0.9 1.9 1.0 1.5 0.8
1.1 0.42 YML107C 1.1 0.7 0.4 1.8 2.2 1.1 1.5 1.3 0.6 0.9 0.9 0.7
0.6 1.3 1.0 1.3 1.2 1.5 0.67 YMR031C 0.7 0.8 1.2 2.1 0.6 0.7 0.8
0.9 1.5 1.1 0.8 0.7 1.0 1.0 0.7 1.6 0.9 1.3 1.26 YMR204C 1.1 1.9
1.3 2.3 1.0 0.6 0.7 1.0 1.0 2.2 0.7 0.7 1.1 1.2 1.5 1.1 0.9 1.1
0.31 YMR206W 1.4 1.4 2.3 3.9 1.1 1.0 1.3 0.9 1.0 9.0 1.8 1.0 1.2
1.4 0.3 2.2 1.0 1.2 0.17 YNL010W 1.5 1.0 0.7 1.9 1.0 1.2 1.1 1.8
0.5 0.6 1.1 0.9 0.7 1.2 0.9 1.2 1.0 1.7 4.53 YNL127W 1.1 1.2 0.7
3.6 0.7 1.2 0.8 1.0 2.7 2.2 1.0 1.0 1.7 1.0 1.5 1.4 0.9 1.4 0.36
YNL217W 1.1 1.2 0.5 1.7 2.1 1.5 1.3 1.4 0.3 0.9 0.7 1.0 1.0 0.9 0.5
1.0 1.3 2.1 2.35 YOL118C 2.6 2.2 1.3 2.2 1.5 3.2 1.1 3.2 1.4 0.6
1.7 3.0 1.0 0.5 0.9 1.0 0.24 YOR053W 1.0 1.1 0.5 1.7 1.7 0.9 1.6
0.9 1.3 0.8 1.3 0.6 0.9 1.2 1.0 1.3 1.2 1.2 0.77 YOR352W 1.3 0.9
1.0 2.2 1.6 0.9 1.8 1.1 1.7 2.0 1.1 1.0 1.2 1.3 0.7 2.5 1.3 1.7
0.59 YOR394W 1.2 0.8 2.2 1.6 1.6 1.7 1.8 1.0 1.1 2.3 1.9 0.9 1.3
0.9 0.9 1.7 1.6 1.1 0.51 YPL033C 0.8 1.0 0.9 5.1 1.3 0.7 1.0 0.7
0.4 1.6 0.7 0.6 0.7 1.1 0.8 0.4 0.9 0.8 0.23 YPL066W 0.9 1.0 1.1
2.0 1.3 1.3 1.3 0.9 0.5 0.8 1.0 1.1 0.9 0.7 0.7 1.2 1.3 1.3 0.77
YPR014C 1.0 0.7 1.1 7.9 0.8 0.9 0.8 0.9 0.9 0.5 0.7 0.7 1.0 0.9 0.8
0.9 1.1 0.29 YBR005W 1.9 2.6 1.1 2.9 0.8 0.7 1.2 0.9 0.4 1.3 0.8
1.7 1.9 0.9 1.1 1.7 2.9 4.6 1.00 YFL027C 0.8 0.8 1.1 1.3 1.1 0.3
0.4 1.1 1.8 1.3 1.3 0.6 1.1 0.3 1.4 1.2 5.1 5.2 1.74 YGL080W 1.3
1.5 1.1 1.3 1.5 1.4 1.5 1.2 1.1 1.2 0.8 1.0 0.7 1.6 0.9 1.7 1.3 2.9
1.70 YMR252C 1.1 1.0 1.5 1.3 1.3 1.0 1.3 1.1 0.9 1.0 1.4 0.8 1.1
1.1 1.1 2.1 1.5 2.2 0.86 YOR385W 2.8 1.2 0.2 2.5 1.5 1.0 1.2 1.0
1.5 2.2 1.2 0.6 2.8 0.8 0.8 1.2 4.6 5.9 1.17 YAR033W 1.0 0.8 1.5
1.1 1.1 1.4 2.1 1.2 1.3 1.6 1.5 0.9 1.5 1.3 0.9 2.0 1.1 3.0 1.15
YBR151W 0.8 0.8 1.3 1.2 1.2 1.7 1.3 0.8 0.8 0.9 0.9 0.9 1.1 0.8 1.0
3.0 1.4 2.4 1.83 YHR162W 1.2 1.2 0.9 1.8 1.2 1.3 1.7 1.4 1.0 1.7
1.3 1.2 1.5 2.0 1.1 1.4 1.3 2.7 3.64 YLR165C 1.4 0.8 1.3 1.1 1.1
1.5 1.4 1.1 1.7 1.0 1.4 0.9 1.2 1.4 0.5 1.6 1.1 2.1 0.78 YNL157W
1.4 1.1 0.7 1.5 1.9 0.9 1.3 1.1 1.7 1.4 1.3 0.9 1.6 1.5 1.0 1.0 1.9
2.3 1.41 YOL002C 0.9 0.7 0.5 1.0 2.0 0.9 0.4 0.8 0.1 0.3 0.8 1.1
0.2 0.5 0.6 1.7 1.5 2.1 5.33 YPL233W 1.2 0.9 0.5 1.1 1.4 0.6 1.0
1.0 0.3 0.6 0.9 0.6 1.0 1.0 0.4 1.0 1.9 1.9 0.48 YGR149W 1.4 1.3
1.8 1.9 1.0 1.7 1.8 0.8 0.6 0.6 1.8 1.2 2.6 1.0 2.4 1.3 2.0 1.7
0.71 YNL043C 1.0 4.4 1.6 1.3 0.8 0.6 0.9 0.9 0.4 0.4 0.7 0.9 2.1
1.2 1.6 0.8 2.7 1.6 0.68 YPL067C 1.2 1.6 2.8 1.4 1.0 0.8 1.2 1.2
0.8 0.9 1.4 0.9 0.7 1.5 1.1 2.9 1.7 0.40 YPL170W 1.2 1.3 0.9 1.1
1.9 1.1 0.6 1.1 1.4 1.0 1.1 0.9 1.1 1.4 1.2 1.6 2.2 1.4 1.05
YGL051W 1.1 1.0 1.6 1.7 1.3 1.0 1.3 0.8 1.1 1.8 1.4 1.0 1.5 1.2 0.8
2.6 1.4 1.9 1.06 YIL112W 1.1 1.4 2.8 1.9 0.6 1.3 1.1 0.9 1.3 2.0
1.4 1.2 1.1 1.3 1.8 2.4 1.2 1.3 0.45 YLR052W 1.0 1.5 0.8 1.3 1.0
0.8 1.0 1.2 0.4 1.1 1.1 1.0 0.8 1.2 1.0 2.4 0.7 0.9 0.77 YNL203C
0.9 1.3 0.3 3.2 1.0 1.7 1.6 0.8 0.3 1.1 0.9 1.2 2.7 1.2 5.6 1.3 1.7
0.21 YNR014W 1.0 0.8 1.7 1.2 1.2 0.7 1.7 0.9 0.3 2.3 4.4 0.9 1.5
4.9 1.0 2.4 1.1 1.0 0.31 YAL028W 0.9 0.7 1.1 2.0 1.0 0.6 1.2 0.8
1.6 1.3 1.0 1.0 1.5 1.6 2.2 1.7 1.0 1.0 0.30 YBL095W 0.8 1.4 1.2
1.4 1.1 0.9 1.1 0.9 1.0 0.6 1.2 0.8 1.0 1.0 0.4 2.2 1.3 1.9 0.72
YBR157C 0.7 1.0 0.4 1.4 1.3 1.2 1.6 0.7 0.6 0.3 0.6 0.6 0.5 0.9 0.2
1.9 1.3 0.8 0.69 YDL091C 1.1 1.3 1.8 1.4 0.7 0.8 1.3 1.3 1.6 1.5
1.5 1.0 1.3 1.5 1.9 2.4 1.1 1.6 0.47 YDL216C 1.1 1.1 0.7 2.0 1.6
1.6 1.2 1.6 1.3 1.3 0.7 0.9 1.2 1.1 1.0 1.8 1.0 1.6 0.42 YDR067C
1.3 1.2 0.7 2.7 0.9 1.1 1.3 1.8 1.0 1.3 0.9 0.9 1.2 1.5 1.5 2.4 1.3
1.4 0.76 YDR186C 0.7 0.9 0.7 0.7 1.3 0.7 1.4 1.2 1.2 1.6 0.7 1.1
1.1 0.8 0.8 2.3 1.1 0.9 0.50 YDR196C 0.9 0.9 0.7 1.1 1.0 1.7 1.7
1.5 1.6 1.1 1.3 0.7 1.2 1.0 0.7 2.7 1.2 1.9 1.54 YDR262W 1.3 1.8
0.8 1.2 1.7 1.3 1.7 1.2 0.9 1.7 1.6 0.8 0.9 1.7 1.5 3.8 1.0 1.4
1.11 YDR306C 0.9 1.2 0.7 1.8 1.7 1.2 1.6 1.3 2.0 1.4 2.1 0.9 1.2
1.1 1.2 2.4 1.0 1.5 0.77 YDR319C 1.3 0.9 0.8 1.1 1.2 1.2 1.7 1.3
1.1 1.1 1.3 1.0 1.3 0.8 2.0 2.1 2.2 1.23 YER188W 1.3 0.9 1.2 1.9
0.9 1.5 1.2 0.7 0.4 0.9 1.2 0.9 1.1 1.1 0.3 2.5 1.0 1.1 0.61
YGL004C 0.8 1.4 1.3 1.0 1.0 1.4 2.9 1.4 1.8 2.2 1.0 0.8 1.3 0.9 0.6
2.2 1.1 1.4 0.48 YGR141W 0.8 1.6 1.6 1.7 1.1 1.5 1.5 0.9 0.3 1.0
0.6 0.6 1.0 0.7 2.6 2.1 1.1 1.3 0.65 YHR080C 0.6 1.8 1.9 0.7 0.8
1.8 1.1 1.1 1.9 1.2 0.7 1.2 2.0 0.9 0.9 2.3 1.1 1.3 0.49 YHR097C
1.6 0.7 0.7 0.9 0.8 0.8 0.7 0.4 0.6 0.7 0.8 1.3 0.9 2.7 2.0 1.7 1.4
0.24 YIL077C 0.9 0.8 1.2 1.2 1.3 1.8 1.2 0.9 1.5 1.4 1.3 1.6 1.3
1.3 0.9 2.4 1.3 1.1 0.75 YJL046W 0.9 0.9 0.6 1.8 1.0 0.7 1.5 1.1
1.8 2.7 4.2 0.9 1.3 1.3 1.0 2.5 1.0 1.3 0.68 YLL005C 1.0 1.1 1.1
1.2 1.6 1.9 1.3 1.0 0.4 1.0 0.9 0.8 1.1 1.7 1.0 2.1 1.1 1.2 0.44
YLR151C 1.4 2.0 1.4 1.0 1.0 1.4 1.4 1.5 0.9 1.1 0.5 0.7 1.3 0.7 2.4
1.0 1.4 0.30 YLR271W 1.6 1.2 0.8 1.8 1.4 1.4 1.7 1.5 1.0 1.0 1.3
0.8 1.2 1.2 1.0 3.0 1.5 1.8 0.78 YMR025W 1.2 1.2 0.7 1.5 1.3 1.3
1.4 1.2 1.0 1.6 1.2 0.9 1.2 1.8 1.1 2.4 1.0 1.5 0.42 YMR135C 1.0
1.0 1.1 1.9 1.8 1.0 1.0 1.0 1.1 1.4 1.1 1.0 1.3 1.0 1.4 2.3 1.5 1.3
1.06 YMR210W 1.0 1.1 1.8 1.9 0.6 0.8 1.1 1.1 1.5 2.2 0.8 0.9 1.0
1.0 1.0 2.2 0.8 1.5 0.56 YNR040W 0.8 4.9 0.5 0.9 0.9 1.6 2.1 1.3
1.1 0.8 1.2 0.6 0.8 1.5 0.7 2.1 1.1 1.0 0.30 YPL039W 1.2 0.9 0.6
1.3 1.4 1.5 1.5 1.4 1.1 1.0 0.9 0.9 1.1 1.1 0.6 2.4 1.1 1.1 0.52
YPL099C 1.1 1.9 0.7 2.0 0.9 1.2 1.4 1.4 2.4 1.7 0.8 0.9 1.1 1.3 0.5
2.1 1.0 1.7 0.92 YPL107W 1.2 0.8 1.1 1.3 1.0 1.1 1.2 1.5 1.4 1.3
1.1 0.7 0.8 1.7 0.7 1.8 1.0 1.1 0.59 YPL138C 1.1 1.7 1.1 1.8 0.7
0.5 1.1 1.3 1.1 1.5 0.5 0.9 0.6 1.3 2.7 2.6 0.8 1.1 0.38
[0026] TABLE-US-00003 TABLE 2 Mitochondria-located protein genes
The level of expressed mRNA in the presence of chemical
substance/The level of expressed mRNA in the absence of chemical
substance yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11)
(12) (13) (14) (15) (16) (17) (18) Intensity YJR048W 1.3 0.9 2.2
1.4 0.8 0.5 0.3 0.9 0.5 1.5 1.0 0.8 0.4 2.5 0.6 1.5 1.2 1.2 1.19
YOR226C 1.3 2.2 1.7 1.1 1.3 1.2 1.2 1.2 1.3 5.9 1.5 0.6 0.9 2.7 1.0
0.7 1.0 0.7 0.58 YDL174C 0.9 1.8 0.9 1.3 0.5 1.7 3.6 0.8 0.5 1.7
0.9 2.8 5.9 1.1 0.6 5.1 2.2 4.0 0.63 YBL022C 0.4 0.8 1.2 0.7 1.2
1.2 1.0 0.4 2.8 1.2 1.1 0.9 2.6 1.0 1.5 1.0 0.9 0.7 0.76 YCL057W
0.6 1.5 2.3 0.5 1.1 1.8 1.4 1.8 4.2 2.1 1.6 1.0 3.8 1.0 2.8 1.5 0.9
1.1 0.76 YDR258C 1.6 2.3 2.8 1.4 1.3 2.4 3.9 1.9 4.9 13.3 1.7 1.8
5.2 1.5 0.6 1.0 1.3 1.3 0.87 YGR028W 1.4 3.5 1.0 1.8 0.9 1.5 2.1
1.4 1.7 2.0 1.1 1.5 2.6 1.2 1.0 2.2 1.5 2.6 0.91 YGR244C 1.0 1.2
1.6 1.6 0.8 2.6 3.9 1.8 1.4 1.1 1.8 1.9 2.6 1.2 2.0 2.6 1.9 3.1
1.12 YKL142W 1.8 2.7 3.1 1.4 0.7 3.4 6.9 2.3 5.8 5.9 2.0 1.9 3.3
2.3 1.3 3.3 2.4 3.6 1.68 YNL055C 1.1 1.8 5.5 2.0 0.9 2.6 1.2 0.7
1.1 1.0 1.9 1.7 2.4 0.9 1.1 2.6 1.2 1.7 4.10 YNL071W 0.9 0.9 1.7
1.5 0.6 1.3 1.4 0.9 1.1 1.2 1.6 1.3 2.5 0.8 1.1 1.1 1.0 1.2 1.61
YOR020C 1.4 2.1 1.7 1.7 1.5 2.3 1.7 1.7 5.8 2.6 2.5 0.8 3.0 1.6 1.5
1.4 1.4 1.7 1.66 YOR037W 1.0 1.5 0.6 1.4 1.5 1.6 2.5 1.5 1.3 1.0
1.2 1.2 2.1 1.0 0.9 1.4 1.2 1.6 0.61 YDL198C 1.4 1.0 2.1 1.4 0.7
0.8 1.0 1.1 1.9 2.7 2.5 1.2 2.0 1.7 1.2 1.4 1.5 1.1 1.19 YDR231C
1.1 1.6 1.0 1.5 1.1 2.2 1.7 1.3 1.5 1.4 1.3 1.1 2.4 1.5 1.0 3.0 1.2
1.3 0.92 YER178W 0.8 0.9 3.6 1.0 0.7 2.5 1.6 0.8 1.7 1.3 2.5 1.3
2.4 0.9 1.8 1.0 1.1 0.9 2.18 YFL016C 0.8 1.0 1.6 0.9 1.3 1.3 1.4
0.7 6.4 2.9 1.2 1.0 2.8 0.8 0.8 0.6 1.2 0.9 1.25 YGR008C 2.1 3.0
1.7 3.2 0.9 2.9 3.7 1.9 3.1 2.4 2.6 2.0 3.4 1.3 1.5 2.3 1.7 4.2
3.03 YIL155C 1.0 0.7 1.4 3.7 1.3 1.4 2.2 1.0 2.5 2.9 1.3 1.4 2.0
1.3 1.4 3.8 1.1 1.4 0.51 YJL102W 1.1 0.7 0.4 0.8 1.3 1.6 0.6 0.9
3.1 2.2 0.7 0.8 2.6 1.5 1.5 0.6 1.0 1.1 0.22 YJR045C 0.5 1.9 3.9
0.5 1.2 1.0 0.8 3.2 3.0 1.4 1.0 2.3 0.5 2.3 0.8 0.7 0.9 3.78
YLR259C 0.7 1.0 3.1 1.6 1.1 0.9 1.8 0.8 1.8 2.6 3.0 0.7 2.5 0.8 2.1
1.3 0.8 1.0 2.09 YLR348C 1.1 4.5 1.2 1.2 0.9 1.9 0.9 0.9 2.1 1.3
1.3 0.9 1.9 1.0 2.4 1.1 1.1 1.0 0.64 YML054C 1.5 1.8 1.3 3.4 1.3
1.8 1.2 1.5 4.1 1.8 1.4 1.8 2.8 2.1 1.1 7.8 1.1 1.6 0.25 YMR089C
0.8 1.1 0.9 0.9 0.8 1.2 1.2 1.3 5.6 2.5 1.3 0.8 2.3 0.9 1.8 1.1 0.9
1.1 0.69 YMR152W 0.9 1.1 1.8 0.9 0.8 7.5 0.8 0.8 2.7 1.3 1.2 1.3
1.9 1.1 0.6 1.0 1.5 0.9 0.71 YNL104C 1.1 1.3 3.0 0.9 0.8 0.8 0.6
0.9 1.1 2.0 2.1 1.1 2.1 0.9 2.5 1.5 0.9 0.9 1.69 YOR130C 0.8 1.7
1.4 1.0 1.8 1.6 1.3 0.8 2.0 1.7 0.6 0.9 2.1 1.3 1.0 0.8 1.5 1.1
0.51 YPR024W 0.7 1.0 1.3 1.0 1.3 1.0 1.4 0.7 3.0 1.7 0.9 0.8 2.5
0.7 1.0 1.6 1.1 0.8 0.84 YPR067W 1.6 1.2 1.7 0.9 1.3 1.3 1.5 1.4
3.5 3.4 1.8 1.0 3.0 1.6 1.3 0.8 1.0 1.0 0.66 YBR029C 0.7 0.2 1.8
1.0 1.4 0.8 0.4 0.7 2.0 1.1 0.7 1.3 1.7 0.9 3.5 0.9 0.6 0.8 1.56
YCL009C 0.6 0.9 2.0 0.5 0.7 1.8 1.3 1.1 0.9 1.6 1.5 1.7 1.6 0.7 6.5
0.9 1.1 0.8 0.68 YER026C 0.8 0.6 3.3 1.0 1.2 2.5 1.6 0.8 0.9 1.5
0.9 1.7 1.9 1.1 4.0 1.4 1.7 3.2 4.48 YLR109W 0.8 2.9 6.0 0.9 1.3
2.1 2.6 0.9 2.4 2.7 1.5 1.6 3.2 2.3 3.9 1.8 1.1 1.2 3.86 YMR189W
0.7 0.8 1.9 2.8 0.4 1.9 0.8 0.4 0.7 0.9 8.2 0.6 0.9 1.6 5.6 0.9 1.0
0.8 0.88 YNL169C 0.7 1.4 1.4 1.2 0.7 1.4 0.7 0.8 1.1 1.1 0.8 1.0
1.7 0.9 3.4 0.8 1.1 1.3 1.05 YER069W 1.3 0.8 3.3 1.4 1.5 1.3 1.0
1.5 0.8 10.4 1.5 0.8 1.4 1.3 2.4 1.1 1.1 0.9 0.25 YIL022W 0.8 0.7
1.1 1.6 0.8 1.2 0.7 0.8 1.1 1.3 1.0 0.9 1.2 0.6 2.9 1.1 0.8 0.7
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1.4 1.3 1.9 1.3 0.9 1.4 0.9 1.3 2.05 YOR136W 1.0 0.9 3.5 1.0 1.5
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1.1 1.4 0.7 1.0 1.4 1.8 4.07 YAL054C 1.2 1.1 1.4 1.6 1.1 2.2 1.1
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1.1 1.3 2.1 1.4 1.5 0.8 1.5 1.1 0.9 1.1 1.5 1.1 2.3 0.9 1.1 1.42
YHR037W 0.7 0.9 1.3 1.6 0.9 1.8 1.2 1.0 0.9 2.2 1.7 1.1 1.1 1.1 1.1
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3.2 1.2 1.6 1.1 2.1 0.9 1.7 1.5 1.1 2.5 1.9 3.9 1.52 YKL138C 1.2
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1.29 YKL150W 1.1 2.0 3.0 1.4 1.4 2.3 2.4 1.3 1.1 1.3 1.9 1.2 1.8
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1.6 0.7 2.1 1.2 2.1 1.52 YHR008C 1.3 5.4 4.8 1.8 0.6 1.0 0.7 0.9
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YAL039C 1.1 2.2 1.7 1.0 1.1 0.8 1.0 1.2 1.6 2.2 1.1 1.4 1.6 1.2 3.3
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1.3 0.7 0.9 0.4 0.6 0.6 1.09 YBL030C 1.0 0.9 4.5 0.9 0.7 1.1 0.9
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3.2 1.5 1.3 1.7 1.5 0.8 1.0 1.3 1.2 1.3 1.7 0.8 1.1 1.5 0.9 1.0
3.62 YKL141W 1.6 1.1 4.7 1.7 1.5 1.2 0.5 0.8 0.8 0.5 1.2 0.8 0.8
1.4 0.6 2.8 0.9 1.8 2.84 YKR066C 0.9 1.4 5.5 0.7 1.0 0.9 0.5 0.7
0.7 2.4 1.3 0.9 0.6 1.5 0.6 1.3 0.9 1.1 1.25 YMR083W 1.4 1.7 2.6
1.1 1.5 1.8 1.7 1.1 0.4 1.1 1.6 0.7 0.9 0.8 1.3 1.3 0.9 1.1 2.52
YMR203W 0.8 0.7 3.0 1.4 0.6 1.1 0.8 0.7 0.7 1.2 2.3 0.7 1.1 0.7 1.2
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2.1 1.0 0.9 0.6 1.0 0.9 0.7 1.2 3.49 YDR178W 2.0 2.0 3.4 2.2 0.9
2.1 0.6 0.9 0.9 0.8 2.0 1.3 1.5 1.5 0.7 3.0 1.2 2.3 2.27 YDR298C
1.3 1.2 2.6 1.3 1.3 1.2 1.0 1.2 1.0 1.6 1.2 1.1 1.2 1.5 0.8 2.0 1.1
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0.6 1.1 0.6 2.1 1.1 1.5 1.59 YGR082W 1.0 0.9 2.2 1.0 0.9 1.1 0.9
0.8 0.6 0.9 1.3 0.8 0.5 0.9 1.2 1.3 0.9 0.8 1.47 YJL133W 1.0 1.0
2.0 0.9 0.9 0.5 0.5 0.9 0.6 1.4 1.2 0.8 0.8 0.7 0.9 0.6 0.8 0.7
0.91 YJR077C 1.1 1.1 2.0 1.6 0.9 0.9 0.7 0.8 0.4 0.7 1.6 1.0 0.9
0.7 1.5 0.7 1.0 0.8 1.79 YJR121W 0.9 1.1 3.3 1.0 0.8 1.5 1.0 0.7
0.8 1.3 0.9 0.8 1.0 0.7 0.9 1.2 1.1 1.4 3.99 YKL148C 0.9 0.8 3.7
0.7 0.8 0.5 0.6 0.8 1.7 1.7 1.5 0.8 0.8 0.8 0.6 1.1 0.8 1.0 0.54
YLL041C 1.1 0.5 4.6 1.0 1.6 1.2 0.3 0.8 0.7 0.8 1.3 0.8 1.0 1.2 0.4
3.1 1.1 1.7 1.75
YLR304C 0.7 0.6 5.0 0.7 0.6 1.9 0.6 0.6 0.1 2.2 1.6 1.0 0.5 0.7 1.6
1.8 0.5 0.7 2.39 YOR142W 1.0 1.2 3.4 1.0 1.4 1.6 1.0 0.8 1.1 1.5
1.5 0.8 1.4 0.8 1.1 0.8 0.9 1.0 1.31 YOR176W 0.7 2.6 2.7 0.9 1.0
0.9 0.5 1.0 1.0 0.5 1.4 1.3 1.5 0.8 0.8 1.4 1.2 2.1 1.23 YPL135W
0.9 1.2 2.5 1.2 1.6 1.3 1.2 1.0 0.5 2.8 1.3 1.1 1.2 1.1 1.5 1.2 1.5
1.7 1.50 YDR529C 1.8 1.0 0.9 3.2 1.2 0.8 0.5 1.3 0.5 0.6 0.8 0.6
0.7 1.5 0.5 1.8 1.0 2.3 3.11 YGL018C 1.1 1.0 1.8 3.0 1.1 0.4 1.1
0.8 0.5 1.4 1.1 1.0 1.3 1.2 1.1 1.5 0.8 1.0 0.36 YBR003W 0.9 0.8
1.0 1.9 0.7 1.2 1.1 0.9 1.0 1.3 1.3 0.8 1.2 0.8 0.7 2.0 1.1 1.3
1.06 YBR044C 0.8 1.4 0.7 1.9 1.4 1.0 1.5 1.1 0.8 1.2 1.1 0.8 1.2
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YBR282W 1.0 1.0 0.5 2.3 1.0 1.4 1.2 1.4 1.0 0.9 0.9 0.8 1.3 1.4 1.1
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1.2 1.5 2.2 1.7 0.7 1.3 2.0 1.0 2.3 1.0 1.2 0.90 YKL016C 1.5 1.3
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YML120C 1.1 1.2 1.9 1.9 0.6 0.6 0.8 0.9 1.3 1.5 1.3 0.9 1.2 0.8 0.5
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YML129C 1.1 0.9 0.9 1.2 1.7 1.7 1.8 1.2 1.4 2.2 1.2 0.8 1.0 1.4 1.1
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1.1 0.9 0.9 1.4 1.0 0.6 1.4 0.7 1.8 1.2 1.7 1.85 YDR079W 1.3 1.1
0.8 1.1 1.2 1.7 1.3 2.6 0.9 0.8 1.3 1.1 1.3 1.5 0.6 2.6 1.1 1.3
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1.3 1.5 1.3 1.6 1.0 1.4 1.4 1.4 0.8 1.2 1.4 0.6 2.0 0.9 1.4 1.08
YLR295C 1.4 1.1 1.1 1.7 2.2 1.1 1.1 1.2 1.4 1.2 1.3 0.5 0.8 1.2 0.5
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1.4 1.2 1.5 0.4 0.8 1.0 0.8 0.7 1.0 0.9 2.6 0.9 1.3 0.94 YNL073W
0.8 1.4 0.9 1.7 0.6 0.5 1.1 1.0 0.9 1.8 1.1 0.7 1.2 0.7 0.7 1.8 0.8
1.0 0.52 YOR316C 0.7 2.5 1.5 1.5 1.0 0.9 1.4 0.8 1.6 2.0 2.4 1.1
1.6 1.0 1.5 2.2 0.8 1.0 0.93 YPL040C 1.1 1.0 0.8 1.7 0.8 1.1 0.8
1.1 0.2 1.2 0.9 0.9 1.0 1.1 1.1 2.7 0.8 1.1 0.33 YPL134C 1.5 1.0
1.6 1.6 1.4 1.2 1.2 1.3 0.6 0.8 1.7 0.8 1.0 1.4 1.1 3.3 1.3 1.3
0.70
[0027] TABLE-US-00004 TABLE 3 3 DNA repair protein genes The level
of expressed mRNA in the presenoe of chemical substance/The level
of expressed mRNA in the absence of chemical substance yeast genes
(1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15)
(16) (17) (18) Intensity YFL014W 3.4 5.1 5.7 11.0 1.0 9.3 5.5 3.4
13.1 5.8 5.0 4.3 15.2 7.3 6.3 14.2 1.5 8.8 2.14 YGL163C 0.9 0.8 0.6
4.3 1.5 0.9 1.0 1.4 5.8 2.3 0.4 0.9 3.1 1.6 1.8 1.0 0.9 0.8 0.26
YKL145W 0.8 1.4 1.2 1.0 1.4 2.1 1.6 1.5 3.5 2.7 1.8 1.3 2.7 1.0 1.3
1.2 1.1 1.5 2.29 YIL153W 0.8 1.4 1.3 2.9 1.0 0.9 1.6 0.5 4.3 1.1
1.0 1.0 1.2 1.0 2.8 1.3 0.9 0.7 0.32 YIR002C 0.8 1.1 0.5 0.6 1.2
2.2 1.3 1.2 1.7 1.4 0.8 1.3 1.2 1.1 1.1 1.4 1.1 1.2 0.58 YAL015C
1.2 1.1 1.7 1.9 1.1 0.7 1.2 1.1 4.0 2.7 1.4 1.0 1.2 1.6 0.7 2.0 1.1
1.2 0.61 YBR073W 0.7 1.0 0.9 0.7 1.2 0.7 0.6 1.1 2.5 1.8 0.5 0.9
1.4 1.0 1.3 0.8 0.7 0.8 0.63 YDL200C 1.4 2.0 1.2 1.8 1.1 0.6 1.7
1.5 2.4 1.8 1.2 1.1 1.1 1.8 0.7 1.8 0.9 1.6 0.79 YGL058W 1.1 1.1
0.6 0.7 1.0 1.0 0.0 1.3 3.7 1.8 0.8 1.3 1.0 1.3 1.3 0.6 1.1 0.7
1.07 YIL143C 0.9 0.8 1.1 0.9 0.8 1.4 0.8 0.9 7.1 3.5 1.5 0.9 1.7
1.0 1.3 1.1 0.9 0.9 0.56 YML032C 0.8 0.9 1.1 0.7 1.0 0.9 0.8 0.9
3.0 1.1 1.0 0.9 1.8 1.0 1.7 1.2 1.0 1.0 0.66 YNL250W 0.9 2.2 0.8
1.2 0.8 0.8 1.2 1.3 4.2 2.3 1.0 1.4 1.3 1.6 1.3 1.4 1.0 1.0 0.31
YOR386W 1.0 0.8 1.3 1.5 1.2 3.3 1.8 1.0 4.1 3.0 1.4 1.2 2.4 0.9 1.3
1.2 2.1 1.7 0.46 YBL019W 0.9 9.1 0.7 1.2 1.0 1.0 1.2 1.2 2.6 1.4
1.0 0.8 0.9 1.1 0.6 1.9 0.8 1.1 0.38 YDR369C 1.1 1.1 2.4 1.1 1.0
0.6 0.4 1.0 2.4 1.8 1.1 0.9 0.1 0.7 1.2 0.6 0.8 0.7 1.88 YEL037C
0.9 2.0 0.9 1.0 0.5 0.6 0.8 0.8 2.6 1.2 1.0 1.1 2.0 1.0 1.6 0.5 1.0
0.8 0.82 YER162C 1.0 1.2 1.0 1.1 0.9 0.7 0.5 0.9 2.8 1.6 0.5 0.4
0.8 0.8 1.0 1.0 1.2 0.9 0.45 YGR2S8C 0.7 0.9 0.7 0.7 1.5 2.2 1.5
0.8 2.5 1.5 0.3 0.9 1.9 1.2 1.1 1.2 1.0 0.9 0.37 YJR052W 1.1 1.0
1.1 1.0 1.0 1.4 1.2 1.7 4.5 2.3 1.1 1.1 1.8 1.4 1.4 1.4 1.0 1.3
0.36 YOR005C 1.2 1.8 1.0 0.8 1.3 1.3 1.4 1.3 2.4 1.5 1.2 0.9 2.1
1.2 0.8 1.4 1.1 1.0 0.29 YPL022W 0.7 0.8 0.7 1.2 0.8 5.2 0.8 1.0
2.1 1.6 0.8 0.7 1.4 0.9 0.9 1.0 0.9 0.9 0.72 YPL164C 1.1 0.7 1.1
1.0 1.2 1.7 0.9 1.0 2.1 2.0 1.1 0.9 1.0 0.9 1.3 1.4 1.0 1.0 0.25
YPL194W 0.9 1.4 0.4 1.1 1.3 1.1 1.5 1.3 9.6 3.1 0.9 0.9 1.4 1.1 1.4
0.9 1.0 0.8 0.22 YPR025C 1.1 0.8 0.6 0.6 1.6 0.9 1.4 1.3 1.9 1.7
0.9 0.7 1.1 1.3 1.1 1.3 1.1 1.5 0.87 YGR180C 3.1 1.1 1.9 1.0 2.0
0.6 0.5 1.0 1.4 1.5 1.0 0.9 0.9 0.9 1.3 1.2 1.0 1.9 3.90 YEL019C
1.1 1.6 0.3 0.7 0.9 1.5 1.2 0.9 0.7 0.7 1.2 1.0 1.0 1.7 1.5 0.3 0.8
0.9 0.27 YLR288C 1.2 0.8 1.6 1.8 1.7 1.2 1.3 1.5 0.8 1.3 1.4 0.6
0.7 1.2 0.9 1.5 1.2 1.3 0.31 YMR284W 1.1 1.0 0.5 2.0 0.8 0.8 0.8
1.1 1.6 1.8 1.1 0.6 1.0 1.2 0.7 1.3 1.1 1.3 0.54 YMR035W 1.2 1.7
1.5 1.7 0.8 1.5 2.3 1.4 1.7 1.6 1.5 0.5 1.4 1.3 1.1 1.5 2.2 2.4
0.96 YOL043C 1.1 0.9 0.8 1.7 1.2 0.8 1.0 0.9 1.0 1.8 1.2 0.8 0.9
1.5 0.6 2.5 1.0 1.0 0.38 YGR231C 1.0 1.2 0.7 1.0 1.3 1.9 2.1 1.1
3.2 2.3 1.6 1.3 3.9 2.2 1.3 2.5 1.0 1.5 1.74 YHR164C 0.9 1.3 0.9
0.7 0.9 1.4 0.8 1.1 1.3 3.1 0.6 1.2 2.0 1.3 2.2 1.1 0.8 1.0 0.44
YJR046W 1.0 1.2 1.2 1.5 0.8 2.0 0.9 0.9 6.0 2.4 0.6 0.9 3.0 1.0 1.1
0.8 0.7 0.7 0.45 YLR103C 0.8 1.5 1.1 0.4 1.0 1.1 1.3 1.4 0.8 0.5
0.9 1.6 3.0 1.0 0.8 1.5 1.1 1.4 1.32 YMR072W 1.1 1.0 1.4 1.0 1.7
1.6 1.4 1.0 3.0 1.2 1.9 0.8 2.1 1.2 0.8 1.7 0.9 1.9 2.06 YDR054C
1.3 1.0 0.7 1.4 0.7 1.9 1.1 1.5 2.9 3.2 1.9 1.0 2.5 1.1 1.6 1.4 0.8
1.4 1.18 YAR007C 0.7 1.9 0.8 0.5 1.5 1.6 0.8 1.1 4.1 1.7 0.9 0.9
1.7 1.4 1.2 0.9 0.8 1.0 1.03 YGL058W 1.1 1.1 0.6 0.7 1.0 1.5 0.0
1.3 3.7 1.8 0.8 1.3 1.0 1.3 1.3 0.6 1.1 0.7 1.07 YIL036W 0.9 1.3
1.3 1.8 0.9 1.8 1.4 1.1 3.6 2.7 1.2 1.2 1.9 1.1 0.8 1.3 1.1 1.3
0.66 YNL213C 1.7 11.6 0.9 1.5 1.3 1.7 1.4 1.8 3.0 1.5 1.5 0.8 0.9
1.8 1.0 1.7 0.9 1.2 0.70 YNL312W 0.9 1.0 1.6 0.7 1.4 1.7 0.5 1.2
3.7 2.5 1.4 0.9 0.7 1.1 0.8 0.8 1.2 1.1 2.05 YNL261W 1.0 1.3 0.6
1.3 0.7 1.3 1.0 1.1 2.3 1.5 0.8 0.8 0.8 1.4 0.7 1.1 0.8 1.0 0.91
YGR180C 3.1 1.1 1.9 1.0 2.0 1.0 0.5 1.0 1.4 1.5 1.0 0.9 0.9 0.9 1.3
1.2 1.0 1.9 3.90 YJL026W 2.5 2.4 2.9 1.0 1.7 1.0 0.5 1.2 1.0 1.1
1.3 1.0 1.2 1.0 1.1 1.6 1.4 2.1 3.74 YDL017W 0.8 2.3 1.2 1.3 1.2
1.1 1.1 1.2 0.8 1.8 0.8 0.8 0.9 1.3 1.3 1.0 0.8 1.0 0.38 YML058W
1.9 1.2 5.8 1.9 0.6 1.3 0.6 0.7 1.1 1.2 3.3 0.9 1.4 1.1 2.5 1.3 1.3
1.5 2.14 YLR233C 1.1 0.9 2.0 2.0 1.2 0.8 0.8 1.1 0.6 0.5 0.8 0.9
1.0 1.1 1.1 1.1 1.0 1.2 0.43 YMR284W 1.1 1.0 0.5 2.0 0.8 1.2 0.8
1.1 1.6 1.8 1.1 0.6 1.0 1.2 0.7 1.3 1.1 1.3 0.54 YGL163C 0.9 0.8
0.6 4.3 1.5 0.9 1.0 1.4 5.8 2.3 0.4 0.9 3.1 1.6 1.8 1.0 0.9 0.8
0.26 YGL127C 1.0 1.9 1.3 1.7 1.3 0.6 1.0 0.9 1.2 1.5 1.0 1.4 1.7
1.0 1.5 1.3 1.0 1.2 0.54 YMR072W 1.1 1.0 1.4 1.0 1.7 2.4 1.4 1.0
3.0 1.2 1.9 0.8 2.1 1.2 0.8 1.7 0.9 1.9 2.06 YGL249W 1.4 0.8 0.5
0.8 1.1 2.5 1.2 0.9 0.3 2.4 0.6 0.8 0.8 1.9 0.7 1.4 1.0 1.0 0.20
YBR272C 0.8 1.8 1.3 1.0 1.1 1.9 1.1 1.7 2.7 1.1 0.5 1.3 1.0 0.5 1.7
1.1 1.2 0.52 YDL059C 2.6 5.1 1.4 1.7 1.2 1.2 1.1 1.2 10.5 7.8 2.0
1.3 1.7 4.7 0.7 1.5 0.8 0.9 0.63 YAR007C 0.7 1.9 0.8 0.5 1.5 0.6
0.8 1.1 4.1 1.7 0.9 0.9 1.7 1.4 1.2 0.9 0.8 1.0 1.03 YBR073W 0.7
1.0 0.9 0.7 1.2 0.7 0.6 1.1 2.5 1.8 0.5 0.9 1.4 1.0 1.3 0.8 0.7 0.8
0.63 YML032C 0.8 0.9 1.1 0.7 1.0 0.9 0.8 0.9 3.0 1.1 1.0 0.9 1.8
1.0 1.7 1.2 1.0 1.0 0.66 YNL250W 0.9 2.2 0.8 1.2 0.8 0.8 1.2 1.3
4.2 2.3 1.0 1.4 1.3 1.6 1.3 1.4 1.0 1.0 0.31 YCR014C 0.8 1.0 0.8
0.6 1.2 1.1 1.1 1.0 2.4 1.0 0.8 0.7 1.2 1.0 0.7 1.5 1.0 0.9 0.34
YDR369C 1.1 1.1 2.4 1.1 1.0 0.6 0.4 1.0 2.4 1.8 1.1 0.9 0.1 0.7 1.2
0.6 0.8 0.7 1.88 YIL072W 0.8 3.1 1.1 2.6 1.5 1.2 1.7 1.4 2.9 2.1
1.8 1.1 1.4 2.0 1.4 1.4 1.0 1.1 0.23 YOR005C 1.2 1.8 1.0 0.8 1.3
1.3 1.4 1.3 2.4 1.5 1.2 0.9 2.1 1.2 0.8 1.4 1.1 1.0 0.29 YPL164C
1.1 0.7 1.1 1.0 1.2 1.7 0.9 1.0 2.1 2.0 1.1 0.9 1.0 0.9 1.3 1.4 1.0
1.0 0.25 YPL194W 0.9 1.4 0.4 1.1 1.3 1.1 1.5 1.3 9.6 3.1 0.9 0.9
1.4 1.1 1.4 0.9 1.0 0.8 0.22 YGR180C 3.1 1.1 1.9 1.0 2.0 0.6 0.5
1.0 1.4 1.5 1.0 0.9 0.9 0.9 1.3 1.2 1.0 1.9 3.90 YEL019C 1.1 1.6
0.3 0.7 0.9 1.5 1.2 0.9 0.7 0.7 1.2 1.0 1.0 1.7 1.5 0.3 0.8 0.9
0.27 YML058W 1.9 1.2 5.8 1.9 0.6 0.6 0.6 0.7 1.1 1.2 3.3 0.9 1.4
1.1 2.5 1.3 1.3 1.5 2.14 YLR288C 1.2 0.8 1.6 1.8 1.7 1.2 1.3 1.5
0.8 1.3 1.4 0.6 0.7 1.2 0.9 1.5 1.2 1.3 0.31 YMR284W 1.1 1.0 0.5
2.0 0.8 0.8 0.8 1.1 1.6 1.8 1.1 0.6 1.0 1.2 0.7 1.3 1.1 1.3 0.54
YMR096W 1.7 1.7 1.1 0.8 1.0 2.2 1.9 2.0 3.3 3.7 1.5 1.4 8.4 4.7
28.9 2.2 2.2 1.0 0.62 YGL091C 2.0 1.8 1.0 1.7 0.8 1.6 1.3 1.8 10.8
6.0 2.1 1.2 2.5 3.1 0.7 1.0 1.4 1.8 0.96
[0028] TABLE-US-00005 TABLE 4 Energy system protein genes yeast The
level of expressed mRNA in the presence of chemical substance genes
(1) (2) (3) (4) (5) (6) (7) (8) (9) (10) YCR107W 12.1 2.6 1.8 1.6
0.7 1.5 1.5 15.6 196.6 34.0 YDL243C 14.5 2.7 2.4 1.0 1.1 2.2 1.6
11.8 64.2 29.6 YFL056C 19.0 2.3 2.3 1.5 0.9 0.6 1.4 18.5 162.3 31.3
YFL057C 20.9 5.9 1.5 1.8 0.9 1.2 1.8 18.0 51.8 46.1 YJR155W 7.6 3.7
1.4 2.5 0.7 1.4 1.7 10.6 38.2 18.8 YNL331C 8.6 3.6 1.3 1.0 1.6 1.8
1.9 13.1 42.6 36.3 YOL165C 10.1 4.5 1.8 0.9 0.9 1.7 1.4 17.8 46.9
23.3 YPL171C 15.2 4.1 3.5 2.2 1.1 1.3 1.7 20.5 60.0 50.6 YDL021W
5.1 1.7 2.4 3.7 1.7 6.5 5.9 2.7 2.5 7.4 YGR043C 2.6 3.7 3.2 7.9 0.9
16.3 6.5 2.6 10.9 8.4 YHR179W 3.3 2.3 2.6 0.7 1.2 3.7 1.9 3.3 3.6
5.8 YJR048W 1.3 0.9 2.2 1.4 0.8 0.5 0.3 0.9 0.5 1.5 YKR097W 1.6 2.4
1.3 3.3 1.1 1.7 3.7 2.5 1.9 3.3 YML087C 1.8 1.6 0.8 2.5 0.9 0.9 1.1
1.3 1.9 4.9 YPL088W 3.3 1.3 0.6 2.5 1.5 7.1 3.7 1.9 0.6 2.8 YDL174C
0.9 1.8 0.9 1.3 0.5 1.7 3.6 0.8 0.5 1.7 YCR012W 1.2 1.5 5.1 1.2 1.1
2.5 1.4 0.8 1.4 1.5 YFR053C 1.8 1.4 3.0 2.2 0.9 3.2 2.1 2.8 0.6 1.1
YGL062W 0.6 1.3 1.1 0.6 0.9 1.0 1.3 0.8 1.6 2.5 YGR192C 1.4 1.0 3.8
1.0 1.1 1.7 1.7 1.1 0.9 1.3 YGR244C 1.0 1.2 1.6 1.6 0.8 2.6 3.9 1.8
1.4 1.1 YGR254W 1.2 1.3 3.8 1.3 1.2 1.9 1.5 1.4 0.8 1.2 YIL160C 0.8
2.4 2.3 3.5 1.0 1.6 1.1 1.2 3.2 3.8 YJL052W 1.6 0.9 4.0 1.8 0.7 2.4
2.1 1.5 1.6 2.0 YJR009C 1.1 1.7 5.6 1.0 1.2 1.6 1.6 1.1 1.1 1.3
YLR345W 1.4 1.4 1.4 1.2 1.2 1.6 1.2 1.4 4.5 4.0 YMR118C 1.3 2.9 1.4
1.6 1.2 2.0 1.0 1.0 9.3 1.4 YNL071W 0.9 0.9 1.7 1.5 0.6 1.3 1.4 0.9
1.1 1.2 YNL241C 1.3 2.5 4.3 1.0 0.8 0.9 3.2 0.9 3.4 7.4 YPL240C 0.7
1.4 2.4 0.9 1.3 1.2 1.4 1.2 3.5 2.6 YAL060W 1.1 1.8 3.2 2.7 1.2 4.2
3.3 0.9 0.6 2.5 YCL040W 0.9 5.6 10.1 2.0 0.5 3.5 2.9 0.7 0.9 3.0
YDR001C 1.0 2.2 2.6 1.0 1.1 2.2 1.5 0.9 2.2 3.0 YDR231C 1.1 1.6 1.0
1.5 1.1 2.2 1.7 1.3 1.5 1.4 YER178W 0.8 0.9 3.6 1.0 0.7 2.5 1.6 0.8
1.7 1.3 YGR008C 2.4 3.0 1.7 3.2 0.9 2.9 3.7 1.9 3.1 2.4 YGR256W 1.2
1.5 2.3 0.8 0.9 6.2 1.4 2.2 3.4 2.5 YHL008C 0.9 0.5 1.0 1.6 0.8 0.8
0.7 0.9 1.6 1.7 YHR174W 1.1 1.4 3.3 1.2 1.3 1.5 1.6 1.2 1.0 1.5
YIL045W 1.7 1.4 1.9 2.2 1.3 1.7 1.6 1.1 2.1 3.2 YKL035W 1.0 0.9 4.8
1.2 0.8 1.2 0.6 1.0 0.8 1.2 YKL152C 1.4 1.3 1.9 0.9 1.3 1.6 1.5 1.0
0.9 1.5 YML054C 1.5 1.8 1.3 3.4 1.3 1.8 1.2 1.5 4.1 1.8 YML100W 0.8
2.7 10.6 1.4 0.9 2.8 2.2 0.7 1.7 1.4 YML125C 0.8 0.9 0.7 0.7 0.9
1.3 1.0 1.3 2.6 1.6 YMR089C 1.0 1.1 0.9 0.9 0.8 1.2 1.2 1.3 5.6 2.5
YMR105C 2.0 3.0 5.0 4.2 0.9 2.8 2.8 1.1 0.6 2.9 YNL237W 1.3 1.3 1.5
1.0 1.5 4.6 4.9 1.1 0.9 2.1 YOL126C 1.1 0.8 1.0 1.6 0.7 1.5 1.4 0.9
0.8 2.4 YOR347C 0.9 0.9 2.1 2.2 0.7 0.9 0.9 0.8 0.5 0.9 YPR026W 0.9
1.2 5.0 1.3 0.8 1.3 1.0 0.9 3.1 YAL038W 1.0 1.0 3.0 1.4 1.4 1.3 0.9
1.1 0.1 1.1 YDR380W 0.8 0.8 0.8 1.7 1.1 0.4 0.5 0.2 0.2 0.3 YLR273C
1.5 1.0 1.3 2.4 1.2 1.2 1.3 2.8 2.4 YGR207C 1.5 1.1 1.0 1.1 1.5 2.8
1.7 1.9 2.1 2.6 YNL037C 1.4 1.8 1.7 1.1 1.7 2.8 2.8 1.0 0.6 3.2
YOR136W 1.0 0.9 3.5 1.0 1.5 3.9 3.2 1.1 0.3 3.4 YPL271W 1.2 3.2 4.1
1.2 1.4 3.3 1.2 0.9 0.6 1.2 YAL054C 1.2 1.1 1.4 1.6 1.1 2.2 1.1 1.1
8.9 4.1 YEL011W 2.0 1.6 1.7 6.3 1.1 2.8 2.7 0.9 2.5 1.6 YFR015C 1.2
0.8 3.2 2.1 1.2 3.0 7.3 0.7 0.3 1.8 YGL253W 0.8 1.0 3.2 0.7 1.3 2.4
1.7 1.1 0.3 1.4 YIL111W 1.9 1.0 1.8 2.7 2.6 3.2 1.2 1.6 1.1 YKL150W
1.1 2.0 3.0 1.4 1.4 2.3 2.4 1.3 1.1 1.3 YPR006C 1.9 1.5 0.5 1.9 2.0
2.4 2.8 1.5 1.5 3.9 YBR145W 1.5 0.7 2.8 0.9 1.1 11.5 58.8 1.0 0.1
1.1 YBR299W 2.0 0.9 1.1 3.5 1.6 0.8 3.6 2.2 1.1 5.3 YEL020C 1.0 1.5
0.8 2.9 1.5 1.3 2.4 1.2 1.4 1.1 YGL134W 1.2 1.3 0.5 0.8 1.4 1.2 2.3
1.4 1.1 1.4 YOL157C 1.0 1.1 1.3 2.5 1.4 0.9 2.7 1.4 2.3 4.8 YBR126C
0.8 1.9 5.6 1.2 0.7 2.9 2.3 0.6 1.7 YCR005C 1.2 1.9 2.0 1.2 0.9 1.6
4.4 1.2 1.5 1.5 YIL172C 1.1 1.1 1.6 1.7 1.3 2.5 1.6 2.8 7.1 YOR221C
0.8 1.0 0.9 1.1 1.7 0.8 2.1 0.9 1.4 1.7 YBR196C 0.8 0.6 3.9 1.4 0.8
0.8 1.4 1.1 0.3 0.9 YEL047C 1.3 1.9 3.2 1.2 0.8 0.6 1.3 1.0 2.7 2.3
YMR318C 1.8 2.4 2.2 0.7 1.2 2.1 0.8 3.6 2.3 4.8 YER061C 0.9 0.9 1.2
2.5 0.8 0.4 0.9 0.7 0.3 0.7 YJL045W 1.8 2.2 1.6 5.3 0.7 0.6 0.7 0.9
9.7 1.6 YLL009C 1.0 1.2 0.6 1.9 1.5 1.2 1.7 1.0 1.3 1.7 YPR160W 1.4
3.8 3.6 3.3 0.7 4.5 1.8 0.9 0.9 1.3 YDL085W 1.2 1.9 1.2 2.0 1.2 1.2
1.4 1.0 7.8 3.4 YJL221C 1.1 1.0 1.1 1.3 0.9 6.6 2.5 1.8 2.7 4.4
YKL085W 1.5 2.3 1.6 1.2 1.2 1.9 1.5 1.2 1.9 3.0 YLR174W 1.2 1.5 1.7
2.1 0.9 0.9 1.6 1.1 2.5 8.3 YNL009W 1.1 1.9 2.0 1.4 1.4 1.1 1.2 1.1
1.4 3.3 YNL117W 0.9 4.7 1.7 0.8 0.8 1.1 1.7 12.8 4.4 YAL061W 1.7
2.4 3.3 3.8 1.0 1.0 2.0 0.8 5.5 1.4 YBR117C 0.8 1.6 1.5 1.4 0.9 2.3
1.0 0.7 5.9 1.5 YEL071W 1.1 1.6 2.6 0.4 1.3 1.9 2.0 1.2 3.6 2.8
YGR112W 1.0 2.9 1.1 1.3 0.9 1.1 1.3 1.3 2.6 1.3 YLR164W 1.0 2.4 0.3
1.0 1.2 1.2 1.1 1.2 5.3 2.0 YNR032W 1.0 1.5 1.0 2.1 1.5 1.0 1.1 1.0
6.2 2.4 YPL031C 0.9 2.0 1.4 0.8 1.5 1.8 1.6 1.0 5.7 1.4 YPR048W 1.3
2.0 0.9 1.1 0.9 0.6 0.9 1.5 4.0 2.1 YBL058W 0.9 1.5 0.5 1.1 1.6 0.9
1.5 1.2 2.6 2.1 YBR001C 0.9 1.4 1.1 1.4 0.9 1.1 0.9 1.3 2.3 2.1
YCR105W 2.2 1.2 1.2 3.0 0.9 1.0 1.0 1.4 2.0 3.9 YIR031C 0.9 1.6 0.6
0.6 1.6 1.7 1.4 1.0 2.6 1.0 YGL191W 2.3 1.6 1.4 1.8 0.9 1.6 1.0 1.6
1.1 1.3 YLR038C 2.6 1.1 0.6 2.1 1.8 1.2 1.0 1.4 0.4 0.9 YGR087C 1.0
15.0 1.7 0.6 1.0 1.1 1.0 0.8 0.2 0.9 YGL256W 0.9 5.3 1.1 1.3 0.7
0.7 0.5 1.0 0.4 1.2 YDL181W 1.4 1.8 1.9 1.8 1.7 1.2 1.1 0.6 0.7 0.8
YPL262W 1.1 1.7 3.8 1.2 0.6 1.6 1.3 1.0 1.4 5.8 YLR377C 1.1 2.6 1.8
1.2 1.0 0.7 0.9 0.7 1.8 1.6 YBR221C 0.8 0.7 3.2 1.5 1.3 1.7 1.5 0.8
1.0 1.3 YKL141W 1.6 1.1 4.7 1.7 1.5 1.2 0.5 0.8 0.8 0.5 YLR134W 0.9
0.6 2.3 0.8 1.3 2.5 1.1 0.8 0.1 0.7 YLR258W 1.7 1.0 4.2 3.5 0.9 1.8
1.8 0.9 0.8 1.3 YOR178C 1.4 1.3 4.8 2.3 1.0 2.7 0.9 0.9 0.2 1.7
YBL099W 0.8 0.9 3.1 1.4 1.0 0.9 0.9 0.8 0.9 0.7 YDR050C 1.9 1.3 2.3
1.8 0.9 1.7 1.5 1.3 0.4 1.3 YDR178W 2.0 2.0 3.4 2.2 0.9 2.1 0.6 0.9
0.9 0.8 YDR298C 1.3 1.2 2.6 1.3 1.3 1.2 1.0 1.2 1.0 1.6 YEL024W 1.5
0.9 3.8 1.1 1.3 1.1 0.7 1.0 0.7 0.6 YJL121C 1.0 0.5 1.9 0.8 1.0 1.1
0.7 1.0 0.1 0.4 YJR121W 1.2 1.1 3.3 1.0 0.8 1.5 1.0 0.7 0.8 1.3
YKL060C 1.7 0.8 2.5 1.0 1.6 1.3 1.2 1.1 0.3 0.8 YKL148C 0.9 0.8 3.7
0.7 0.8 0.5 0.6 0.8 1.7 1.7 YLL041C 1.5 0.5 4.6 1.0 1.6 1.2 0.3 0.8
0.7 0.8 YLR044C 0.8 0.6 2.2 0.9 1.7 1.5 1.3 0.7 0.0 1.2 YLR284C 0.9
1.0 3.8 1.9 1.6 0.9 0.8 1.2 0.9 0.9 YLR304C 0.7 0.6 5.0 0.7 0.6 1.9
0.6 0.6 0.1 2.2 YLR354C 1.2 2.5 2.3 1.5 1.6 1.5 1.1 1.4 0.4 0.9
YMR205C 0.5 0.7 2.3 0.8 1.2 1.2 0.9 0.7 0.3 0.8 YMR261C 0.8 1.6 3.6
0.8 0.9 0.6 1.3 0.7 1.6 1.3 YMR323W 0.8 1.1 2.9 1.1 0.7 0.4 1.1 0.8
0.5 1.3 YOL086C 1.1 0.5 2.2 1.1 1.9 1.7 1.9 0.8 0.1 1.2 YOR142W 1.3
1.2 3.4 1.0 1.4 1.6 1.0 0.8 1.1 1.5 YPL061W 0.4 1.4 5.0 1.3 1.6 1.7
0.5 0.8 1.3 0.7 YDL107W 1.3 1.3 1.0 2.2 1.0 1.3 1.8 1.8 1.2 1.8
YDR529C 1.8 1.0 0.9 3.2 1.2 0.8 0.5 1.3 0.5 0.6 YGL018C 1.5 1.0 1.8
3.0 1.1 0.4 1.1 0.8 0.5 1.4 YBR185C 1.5 1.0 1.3 2.0 0.8 1.2 1.2 1.1
0.9 1.6 YEL039C 1.1 0.7 1.3 5.1 0.9 1.5 0.6 1.1 1.2 1.2 YGR174C 1.1
1.6 0.6 2.4 1.0 1.4 1.0 1.6 1.8 0.7 YKL016C 1.5 1.3 0.7 1.7 1.5 0.8
1.5 1.6 1.3 1.8 YLR395C 1.8 1.3 2.2 1.9 0.7 0.4 1.0 1.0 0.9 YML120C
1.1 1.2 1.9 1.9 0.6 0.6 0.8 0.9 1.3 1.5 YMR073C 1.1 1.1 1.2 1.5 0.8
0.9 1.0 1.1 1.2 1.2 YOR388C 1.0 1.6 1.3 4.7 1.3 1.4 1.0 0.7 0.1 1.4
YPL275W 0.6 1.5 1.3 5.1 1.2 1.0 1.1 1.0 0.2 1.2 YPL276W 1.2 1.5 1.6
3.0 1.5 1.1 1.2 0.9 -0.2 1.8 YGL205W 1.0 0.9 0.7 0.8 1.1 1.6 0.8
1.2 0.5 0.6 YJL166W 2.1 1.5 1.6 1.3 1.6 0.7 0.8 1.4 1.3 1.2 YNL202W
0.7 1.3 1.2 1.7 0.9 2.0 0.9 1.2 1.3 1.1 YDR377W 1.3 1.1 1.3 1.4 1.9
1.3 1.1 1.3 1.0 0.9 YGL187C 1.5 0.8 1.6 1.8 1.3 1.1 0.6 0.7 0.6 0.6
YJL216C 1.1 4.7 2.2 0.9 0.8 1.5 1.9 1.5 1.3 YKR009C 1.0 1.2 1.5 0.9
1.0 1.8 1.0 0.9 2.4 2.1 YCR046C 1.0 1.2 1.2 1.6 1.0 0.8 1.2 0.9 1.9
1.4 YML129C 1.1 0.9 0.9 1.2 1.7 1.7 1.8 1.2 1.4 2.2 YPR184W 1.2 1.4
5.7 2.2 0.9 1.5 1.3 0.7 1.9 3.2 YDL067C 1.8 1.0 1.6 1.3 2.0 0.9 0.8
1.1 0.9 0.9 YDL078C 0.7 1.1 1.2 0.8 1.3 1.1 1.7 1.0 1.1 1.0 YDR079W
1.3 1.1 0.8 1.1 1.2 1.7 1.3 2.6 0.9 0.8 YGR062C 0.9 1.0 0.7 1.4 0.7
0.9 1.3 0.8 1.0 1.4 YKR058W 1.3 0.9 1.4 1.9 0.8 1.4 1.4 1.5 1.3 1.2
YLR295C 1.5 1.1 1.1 1.7 2.2 1.1 1.1 1.2 1.4 1.2 YMR267W 0.8 1.8 0.7
0.9 1.0 1.4 1.2 1.5 0.4 0.8 yeast The level of expressed mRNA in
the absence of chemical substance genes (11) (12) (13) (14) (15)
(16) (17) (18) Intensity YCR107W 23.0 0.9 4.0 8.3 4.8 3.1 1.3 1.1
0.59 YDL243C 19.6 1.1 4.1 12.0 4.2 3.0 1.8 1.5 0.76 YFL056C 68.3
1.0 4.7 7.8 5.0 3.4 1.0 1.1 0.55 YFL057C 27.7 1.0 4.1 23.4 3.1 3.9
1.6 1.3 0.71 YJR155W 15.4 1.0 5.7 9.4 2.6 5.6 1.3 1.4 0.64 YNL331C
21.8 0.9 3.1 7.5 2.3 4.0 1.7 1.3 0.58 YOL165C 17.6 0.8 3.7 9.1 3.0
1.8 1.6 1.0 0.69 YPL171C 37.0 1.4 2.4 9.3 1.4 1.2 2.4 1.5 0.47
YDL021W 4.7 2.4 5.3 3.7 0.7 7.3 1.9 3.2 0.47 YGR043C 3.6 3.3 6.9
4.1 3.0 13.7 1.6 4.8 0.66 YHR179W 2.0 2.2 2.6 5.8 2.7 1.0 1.9 1.6
2.69 YJR048W 1.0 0.8 0.4 2.5 0.6 1.5 1.2 1.2 1.19 YKR097W 0.8 1.8
17.5 2.1 2.5 2.2 1.1 1.5 0.16 YML087C 1.6 0.8 1.5 2.1 0.3 2.0 0.7
0.8 0.52 YPL088W 1.1 3.6 4.8 1.6 3.2 4.3 9.1 8.3 0.69 YDL174C 0.9
2.8 5.9 1.1 0.6 5.1 2.2 4.0 0.63 YCR012W 1.8 1.2 4.1 0.9 1.4 1.4
0.8 1.3 4.48 YFR053C 1.5 1.7 3.0 0.6 0.6 3.0 1.4 2.2 4.17 YGL062W
0.7 1.6 4.5 1.2 2.7 1.5 1.1 0.9 0.77 YGR192C 2.3 2.2 3.4 1.0 1.9
1.1 1.1 1.3 7.49 YGR244C 1.8 1.9 2.6 1.2 2.0 2.6 1.9 3.1 1.12
YGR254W 1.3 1.7 3.1 0.6 2.4 1.4 1.3 1.2 7.01 YIL160C 2.4 1.0 2.3
1.5 5.6 8.8 2.4 3.0 0.27 YJL052W 4.3 2.4 5.6 1.3 2.3 2.3 1.2 1.9
6.19 YJR009C 1.1 1.5 2.7 1.0 2.1 1.5 1.1 1.3 5.86 YLR345W 2.5 1.6
3.5 1.5 1.0 1.2 1.2 1.4 2.65 YMR118C 0.7 0.8 4.2 0.9 0.9 8.1 0.8
1.0 0.38 YNL071W 1.6 1.3 2.5 0.8 1.1 1.1 1.0 1.2 1.61 YNL241C 3.0
2.0 4.9 1.1 7.0 2.8 1.0 1.0 0.68 YPL240C 1.0 0.8 2.9 0.7 1.2 0.7
0.8 1.0 4.83 YAL060W 2.4 0.8 2.2 0.9 0.9 3.2 1.1 1.8 2.39 YCL040W
8.2 2.3 5.6 0.7 3.4 3.1 1.4 1.7 1.98 YDR001C 0.7 1.1 2.8 1.0 4.4
1.9 1.1 1.6 0.75 YDR231C 1.3 1.1 2.4 1.5 1.0 3.0 1.2 1.3 0.92
YER178W 2.5 1.3 2.4 0.9 1.8 1.0 1.1 0.9 2.18 YGR008C 2.6 2.0 3.4
1.3 1.5 2.3 1.7 4.2 3.03 YGR256W 2.7 1.5 3.9 1.1 2.7 5.3 1.1 0.8
0.94 YHL008C 1.4 0.8 1.8 1.0 1.8 0.9 0.8 0.9 0.40 YHR174W 1.4 1.5
3.6 0.6 2.0 1.1 1.0 1.2 7.34 YIL045W 1.2 1.5 2.0 1.6 0.6 2.9 1.1
1.8 0.37 YKL035W 2.1 1.0 2.0 0.6 1.0 1.5 1.0 1.9 2.54 YKL152C 1.7
1.5 2.7 1.0 1.8 2.0 1.1 1.7 3.28 YML054C 1.4 1.8 2.8 2.1 1.1 7.8
1.1 1.6 0.25 YML100W 3.2 1.2 3.8 1.2 1.8 2.2 1.0 1.5 0.88 YML125C
1.0 1.0 2.2 1.6 1.9 0.7 1.2 0.9 2.21 YMR089C 1.3 0.8 2.3 0.9 1.8
1.1 0.9 1.1 0.69 YMR105C 3.0 1.7 3.3 1.0 0.9 2.0 1.6 2.6 1.21
YNL237W 1.5 1.8 3.2 1.3 1.6 4.4 1.3 1.1 0.21 YOL126C 1.8 1.1 2.6
1.2 1.4 2.5 1.6 2.4 0.59 YOR347C 1.4 1.2 1.8 0.9 2.0 1.4 1.7 1.3
1.31 YPR026W 1.6 1.2 2.3 1.5 3.1 2.5 0.9 1.3 0.26 YAL038W 1.0 1.2
1.8 0.5 3.1 0.9 1.0 1.0 7.02 YDR380W 0.4 0.4 0.4 0.6 2.4 0.2 0.8
0.8 1.04 YLR273C 1.4 0.9 1.7 1.3 2.6 1.5 1.0 1.0 0.20 YGR207C 1.4
1.1 1.0 2.2 0.6 1.8 1.2 1.8 1.49 YNL037C 1.4 1.3 1.9 1.3 0.9 1.4
0.9 1.3 2.05 YOR136W 1.4 1.2 1.5 0.9 1.2 1.3 0.8 1.3 3.20 YPL271W
1.7 0.8 1.2 1.3 0.8 1.4 1.2 1.3 1.34 YAL054C 1.3 1.0 1.8 1.3 0.9
2.5 1.5 1.4 0.24 YEL011W 3.7 1.5 1.5 1.5 0.4 2.4 1.4 2.5 0.89
YFR015C 3.9 0.4 2.5 3.1 0.4 2.4 1.3 1.2 0.66 YGL253W 1.0 1.2 1.5
0.5 0.8 0.4 0.7 0.8 4.63 YIL111W 2.1 0.9 1.7 1.5 1.1 2.5 1.9 3.9
1.52 YKL150W 1.9 1.2 1.8 1.4 0.9 6.1 1.2 2.7 2.20 YPR006C 2.4 1.1
1.8 1.2 0.7 1.6 1.8 2.1 0.46 YBR145W 1.1 1.0 2.0 2.2 1.2 3.6 1.7
2.0 2.17 YBR299W 2.4 1.2 0.7 1.4 0.6 3.9 1.0 1.1 0.32 YEL020C 1.3
0.8 1.2 1.0 1.4 2.1 1.2 1.3 0.31 YGL134W 1.1 0.9 0.7 1.1 0.5 1.7
0.9 1.3 0.53 YOL157C 1.2 1.2 1.4 1.2 1.1 3.5 1.4 1.3 0.41 YBR126C
1.1 1.3 2.1 0.7 1.0 1.7 1.5 1.3 1.96 YCR005C 2.1 0.5 0.7 0.8 0.7
0.7 1.6 1.7 2.38 YIL172C 1.0 1.4 2.0 1.3 1.4 2.8 1.1 1.2 0.42
YOR221C 1.1 0.8 1.0 1.1 1.0 1.4 0.9 1.2 0.39 YBR196C 2.3 1.0 1.4
0.5 1.9 1.1 0.8 1.0 6.60 YEL047C 4.2 1.2 1.6 1.1 1.0 1.3 0.9 1.0
1.02
YMR318C 3.6 0.8 1.8 1.7 1.5 1.1 1.1 1.1 3.17 YER061C 2.2 0.7 0.9
1.0 0.8 1.8 1.2 1.2 0.84 YJL045W 2.3 1.1 1.6 1.2 3.4 2.4 0.9 0.9
0.42 YLL009C 3.5 0.7 0.9 1.4 1.1 2.8 0.9 1.2 1.66 YPR160W 4.4 2.1
2.2 1.1 1.4 5.3 1.0 2.9 1.42 YDL085W 2.7 0.8 1.7 1.2 0.7 4.5 0.9
0.9 0.23 YJL221C 0.8 1.1 1.4 1.1 1.1 3.3 1.1 1.4 0.41 YKL085W 1.8
0.8 1.5 1.0 0.5 1.7 0.9 1.3 2.16 YLR174W 1.3 1.3 1.8 1.7 0.8 4.6
0.9 1.2 0.41 YNL009W 1.3 0.9 1.3 1.3 2.7 3.3 1.2 2.3 0.45 YNL117W
1.4 0.7 1.3 2.0 2.6 1.6 1.1 0.9 0.24 YAL061W 4.1 1.1 1.4 0.7 0.6
1.1 1.4 1.2 0.88 YBR117C 0.4 0.8 2.1 0.9 1.0 12.0 0.7 0.7 0.49
YEL071W 2.1 0.9 1.6 1.2 1.6 1.2 1.1 1.2 1.13 YGR112W 1.3 0.7 1.1
1.1 1.2 2.8 0.9 1.2 0.31 YLR164W 3.2 0.7 1.0 1.5 0.7 11.0 1.5 1.2
0.31 YNR032W 1.4 0.6 1.3 1.4 0.9 1.0 1.2 1.3 0.71 YPL031C 1.4 0.8
1.6 0.9 0.7 2.0 1.4 1.2 0.49 YPR048W 1.0 0.8 0.6 1.2 0.6 0.8 0.7
0.8 0.75 YBL058W 1.3 0.8 1.6 1.3 1.8 1.8 1.0 1.4 1.42 YBR001C 1.0
1.0 2.0 1.2 1.8 1.4 1.0 1.6 0.61 YCR105W 2.3 0.9 1.9 1.9 3.1 1.3
1.3 1.1 0.36 YIR031C 1.2 0.8 1.0 1.2 0.8 0.7 0.9 0.8 0.44 YGL191W
1.6 0.9 1.1 1.6 0.7 1.8 1.2 1.7 2.35 YLR038C 1.4 0.6 0.5 1.6 0.7
2.1 1.2 2.1 1.52 YGR087C 0.8 1.2 1.2 0.7 3.5 0.6 1.0 0.6 1.88
YGL256W 1.0 0.9 0.8 0.9 1.0 0.7 0.7 0.8 0.90 YDL181W 0.8 0.9 0.9
1.1 0.4 1.1 1.5 1.4 0.85 YPL262W 1.4 1.1 1.5 1.2 0.6 1.4 1.1 1.2
0.79 YLR377C 0.6 0.6 1.2 2.9 0.8 2.7 0.9 1.4 0.14 YBR221C 1.2 1.3
1.7 0.8 1.1 1.5 0.9 1.0 3.62 YKL141W 1.2 0.8 0.8 1.4 0.6 2.8 0.9
1.8 2.84 YLR134W 1.1 1.2 1.5 0.6 1.7 0.5 0.6 0.8 3.47 YLR258W 1.2
0.9 1.4 1.2 0.6 1.7 1.0 2.0 1.36 YOR178C 4.1 1.7 1.0 1.0 1.1 1.7
1.0 1.5 0.56 YBL099W 2.1 1.0 0.9 0.6 1.0 0.9 0.7 1.2 3.49 YDR050C
2.0 1.4 2.0 1.2 1.9 1.3 1.1 2.3 6.26 YDR178W 2.0 1.3 1.5 1.5 0.7
3.0 1.2 2.3 2.27 YDR298C 1.2 1.1 1.2 1.5 0.8 2.0 1.1 1.6 2.69
YEL024W 0.9 0.8 0.6 1.1 0.6 2.1 1.1 1.5 1.59 YJL121C 1.1 0.6 0.7
0.9 1.0 0.6 1.1 1.0 1.00 YJR121W 0.9 0.8 1.0 0.7 0.9 1.2 1.1 1.4
3.99 YKL060C 2.1 1.3 1.2 0.8 1.6 1.5 1.2 1.7 6.01 YKL148C 1.5 0.8
0.8 0.8 0.6 1.1 0.8 1.0 0.54 YLL041C 1.3 0.8 1.0 1.2 0.4 3.1 1.1
1.7 1.75 YLR044C 1.1 1.4 1.7 0.5 2.2 0.6 0.9 0.9 5.16 YLR284C 1.5
0.6 0.8 1.3 1.0 4.5 2.9 8.1 0.84 YLR304C 1.6 1.0 0.5 0.7 1.6 1.8
0.5 0.7 2.39 YLR354C 1.7 1.2 1.0 0.9 2.4 1.3 1.0 1.5 4.53 YMR205C
1.0 1.1 1.3 0.5 0.9 0.9 0.6 0.5 4.75 YMR261C 0.8 0.9 1.6 0.6 0.8
1.6 0.7 1.1 0.78 YMR323W 2.5 1.2 1.8 1.2 37.3 0.6 1.1 0.6 1.04
YOL086C 2.6 1.3 1.7 0.6 1.6 1.4 1.1 1.3 4.19 YOR142W 1.5 0.8 1.4
0.8 1.1 0.8 0.9 1.0 1.31 YPL061W 1.1 1.0 1.1 0.6 1.7 1.0 1.6 2.6
3.23 YDL107W 1.0 1.0 1.2 1.5 1.0 2.0 1.1 1.5 0.51 YDR529C 0.8 0.6
0.7 1.5 0.5 1.8 1.0 2.3 3.11 YGL018C 1.1 1.0 1.3 1.2 1.1 1.5 0.8
1.0 0.36 YBR185C 1.2 0.7 1.0 1.7 1.0 1.7 0.8 1.3 0.89 YEL039C 1.7
0.6 0.5 1.4 0.4 3.5 0.7 1.1 1.59 YGR174C 1.3 0.9 1.5 1.6 0.7 3.2
1.3 2.3 1.05 YKL016C 1.3 1.0 1.3 1.6 0.7 1.8 1.0 1.7 2.08 YLR395C
1.5 0.6 0.5 1.7 0.4 1.2 1.2 2.3 1.76 YML120C 1.3 0.9 1.2 0.8 0.5
1.5 1.0 1.6 0.74 YMR073C 0.9 0.8 1.2 2.0 0.9 1.5 0.8 1.2 0.69
YOR388C 1.3 0.7 1.1 1.3 4.0 0.8 1.0 0.9 0.21 YPL275W 0.9 0.6 1.0
1.0 1.4 0.9 1.0 1.0 0.28 YPL276W -0.4 0.6 0.9 0.9 1.0 0.6 1.1 0.8
0.22 YGL205W 0.4 1.1 1.0 1.0 2.0 4.1 3.9 9.1 0.24 YJL166W 1.4 0.7
0.8 1.9 0.5 2.3 1.7 4.0 2.31 YNL202W 1.2 0.9 1.8 1.0 1.4 4.2 2.4
3.3 0.47 YDR377W 1.4 0.9 0.7 1.4 0.6 1.8 1.2 2.5 3.00 YGL187C 0.7
0.8 0.7 0.9 0.3 1.4 0.9 2.4 2.73 YJL216C 1.1 1.0 1.1 1.1 1.2 1.5
1.2 2.0 0.25 YKR009C 1.2 1.0 1.8 1.0 1.0 4.6 1.9 2.5 0.27 YCR046C
1.5 1.1 1.5 1.3 1.4 2.8 1.3 1.0 0.63 YML129C 1.2 0.8 1.0 1.4 1.1
2.9 1.3 1.3 1.04 YPR184W 3.6 1.4 2.5 1.3 1.5 3.1 1.0 1.7 0.37
YDL067C 1.4 1.0 0.6 1.4 0.7 1.8 1.2 1.7 1.85 YDL078C 1.7 0.8 1.0
0.8 0.5 2.2 1.1 2.0 1.65 YDR079W 1.3 1.1 1.3 1.5 0.6 2.6 1.1 1.3
1.06 YGR062C 1.6 1.0 1.5 1.2 0.5 1.8 0.9 1.1 0.54 YKR058W 1.5 0.9
0.7 1.3 0.5 2.6 0.8 1.6 0.73 YLR295C 1.3 0.5 0.8 1.2 0.5 2.4 0.9
1.5 1.07 YMR267W 1.0 0.8 0.7 1.0 0.9 2.6 0.9 1.3 0.94
[0029] TABLE-US-00006 TABLE 5 Transport facilitation protein genes
yeast The level of expressed mRNA in the presence of chemical
substance genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) YBR008C
3.0 2.4 4.9 0.7 0.9 1.0 0.9 2.8 54.6 21.1 YBR296C 7.0 4.3 2.2 2.5
1.4 1.4 0.2 1.1 0.4 1.8 YDR406W 0.8 1.2 3.1 1.1 1.0 5.9 1.8 0.6 1.1
1.7 YOR153W 1.6 0.9 5.1 1.1 1.0 7.4 2.6 0.5 3.2 1.2 YGR281W 1.2 1.0
1.3 2.2 0.6 1.9 0.9 0.7 2.7 1.4 YHL047C 0.6 4.4 1.0 1.0 1.2 8.4
16.8 1.5 1.2 11.9 YBR294W 6.3 14.4 0.9 2.6 1.4 1.2 1.1 1.0 5.2 5.2
YGL006W 2.5 1.3 1.3 2.6 1.0 1.0 1.3 0.9 3.0 1.2 YGR197C 1.1 2.4 2.5
1.0 0.7 0.5 1.3 0.8 16.7 3.2 YJL034W 0.7 1.7 3.0 0.8 1.2 1.1 1.3
1.5 2.8 1.1 YNL055C 1.1 1.8 5.5 2.0 0.9 2.6 1.2 0.7 1.1 1.0 YBR052C
1.6 1.6 1.5 2.6 1.4 2.1 3.0 1.3 2.3 2.5 YBR207W 0.8 1.7 0.8 2.0 1.7
1.6 4.3 0.9 1.7 2.2 YBR293W 1.9 3.1 1.0 1.8 0.8 0.9 0.9 0.9 5.5 2.4
YDL198C 1.4 1.0 2.1 1.4 0.7 0.8 1.0 1.1 1.9 2.7 YDL245C 1.0 2.4 1.6
2.2 1.3 1.1 1.2 1.2 0.4 2.8 YDR497C 0.7 0.5 0.6 1.3 0.7 0.6 0.5 0.6
0.4 0.8 YER053C 1.6 1.8 1.9 1.7 0.6 2.8 2.8 1.3 1.3 3.9 YFL041W 0.7
1.6 1.4 1.2 1.2 2.0 3.4 1.0 0.8 5.1 YGR055W 2.5 5.7 12.0 0.7 1.3
1.1 0.6 1.1 5.0 2.4 YJL219W 1.2 2.5 3.1 1.6 1.2 1.5 0.9 1.5 4.0 2.3
YJR106W 0.9 3.8 1.5 1.1 0.9 1.2 1.0 0.9 2.0 1.6 YKL146W 0.8 1.3 1.3
0.9 1.0 1.3 0.9 0.8 4.6 2.8 YLL028W 0.6 0.9 4.6 0.5 0.9 1.7 1.0 0.7
1.2 2.3 YLR348C 1.1 4.5 1.2 1.2 0.9 1.9 0.9 0.9 2.1 1.3 YOL119C 2.6
4.8 1.5 2.3 1.5 0.9 2.2 2.0 5.0 7.4 YOL163W 1.5 3.2 2.1 3.3 0.9 0.5
0.9 1.1 7.5 6.2 YOR035C 1.2 1.2 0.3 1.2 1.0 1.9 1.3 1.0 1.3 1.7
YOR130C 0.8 1.7 1.4 1.0 1.8 1.6 1.3 0.8 2.0 1.7 YOR273C 0.7 1.0 1.7
1.0 1.1 0.4 0.4 0.6 0.6 0.5 YOR332W 1.1 1.0 1.0 1.0 0.9 1.8 0.9 1.5
1.8 1.1 YCR098C 1.6 3.0 1.7 2.0 1.4 1.6 1.2 1.0 1.4 2.4 YGR138C 1.1
1.6 1.0 1.2 0.8 0.8 0.7 1.0 0.5 1.0 YBR295W 1.4 1.5 3.3 1.1 0.8 1.6
0.9 1.2 3.3 YGL255W 0.7 0.9 0.9 0.8 1.4 1.1 1.0 0.7 0.3 5.0 YHL035C
0.7 1.3 0.9 1.9 0.9 4.1 1.7 1.1 0.6 4.6 YIL022W 0.8 0.7 1.1 1.6 0.8
1.2 0.7 0.8 1.1 1.3 YLR378C 0.7 0.9 2.6 0.5 1.0 1.2 0.7 0.5 1.1 0.7
YCL038C 1.6 1.6 1.4 1.6 1.2 3.2 1.5 1.2 1.1 0.9 YFL054C 1.6 1.1 1.4
2.2 1.3 2.4 1.1 1.5 2.0 2.3 YHL040C 1.6 4.9 1.5 0.4 1.1 7.3 4.0 1.5
1.1 11.3 YKR039W 1.4 3.5 1.3 1.7 1.0 2.8 1.0 1.0 1.9 2.0 YPL271W
1.2 3.2 4.1 1.2 1.4 3.3 1.2 0.9 0.6 1.2 YBR068C 1.1 1.0 1.9 2.5 1.4
1.9 1.0 0.8 2.5 YCR037C 0.7 1.0 0.8 0.8 1.3 1.8 1.0 0.7 0.6 0.6
YDL128W 0.8 1.1 2.1 1.0 1.0 2.3 0.9 0.8 0.5 0.7 YDR270W 0.7 1.5 1.4
1.3 1.0 2.2 1.7 1.2 2.9 3.6 YEL065W 0.3 3.8 1.2 0.4 1.4 2.3 4.3 0.9
0.1 4.9 YGL008C 0.6 0.7 3.1 0.9 0.8 1.9 1.4 0.7 0.0 0.4 YGL104C 0.8
2.0 2.1 1.8 1.0 2.1 1.2 0.8 4.6 2.1 YGL167C 0.9 0.7 1.6 1.3 1.2 2.0
1.2 0.8 1.3 1.1 YGR065C 0.8 1.5 2.6 1.1 1.2 2.4 2.4 1.0 1.2 2.6
YHR092C 2.3 1.0 7.5 2.5 1.4 1.7 0.5 1.5 0.2 0.9 YIL088C 0.9 2.1 2.1
1.3 1.6 2.2 1.7 0.8 1.0 1.7 YNL259C 1.6 3.5 1.1 1.2 1.1 3.9 3.8 1.5
1.6 2.1 YOR270C 0.7 0.5 2.0 0.8 0.8 1.8 1.0 0.6 0.4 0.9 YPL265W 0.7
0.4 2.3 1.1 1.0 2.3 8.9 2.3 0.2 1.2 YPR124W 0.2 0.4 0.3 1.4 2.0 2.0
2.9 2.7 0.2 1.5 YER119C 0.7 2.1 1.8 0.7 0.8 1.3 0.8 0.6 5.8 1.2
YFL055W 2.0 6.7 1.3 2.5 1.5 1.1 1.4 1.3 23.9 6.5 YLL055W 2.6 19.0
4.8 1.7 1.0 1.4 1.7 1.4 19.1 14.0 YHL036W 2.2 4.8 3.4 2.0 1.3 1.3
1.0 1.2 9.0 4.4 YHR048W 2.5 1.4 1.4 1.7 1.0 0.8 0.8 1.9 4.5 2.7
YKL221W 1.3 0.7 2.0 1.0 1.0 0.9 1.3 1.2 7.3 2.7 YLR092W 5.0 5.6 1.4
0.6 1.3 1.0 1.3 1.5 12.7 5.8 YML116W 4.1 1.3 1.5 1.4 1.2 0.9 1.4
2.2 1.4 3.1 YBR291C 2.0 0.9 1.0 1.5 0.9 1.1 0.9 2.2 0.9 1.0 YCL069W
0.9 4.5 0.9 0.8 0.9 1.4 1.3 1.2 6.9 YJR095W 1.2 20.5 1.9 6.7 1.2
1.5 2.0 0.9 0.5 6.3 YKL188C 1.3 0.7 1.9 2.4 1.0 0.8 1.1 0.7 2.5 2.8
YKL217W 1.8 2.4 1.0 2.1 1.1 1.2 1.6 1.1 0.9 4.1 YKR105C 0.8 0.9 0.9
1.5 1.0 1.2 1.0 1.3 1.0 5.2 YOL158C 0.7 4.0 2.4 0.9 1.2 2.0 1.6 0.7
1.7 6.1 YPL224C 1.0 2.2 1.3 2.5 0.6 1.3 2.2 1.3 3.2 4.2 YPR201W
33.2 0.9 1.1 1.0 1.2 1.9 0.8 0.9 8.3 5.6 YAL067C 2.7 12.1 1.5 1.4
0.7 1.2 0.8 1.1 7.6 2.9 YDL149W 0.8 2.0 1.2 1.6 1.5 1.0 0.7 1.2 3.2
2.0 YJL094C 1.0 1.7 1.3 2.0 1.4 1.3 1.7 0.8 5.4 2.9 YLL061W 3.6 2.8
9.2 0.4 0.8 0.8 0.9 1.4 3.7 5.5 YPL274W 0.8 4.2 3.8 0.8 0.6 1.1 0.7
0.9 4.1 3.6 YBR241C 0.9 9.3 2.6 0.9 0.9 1.5 1.4 0.7 29.8 2.2
YDL206W 0.9 1.7 1.8 1.4 1.1 5.7 2.0 1.1 1.6 1.5 YDR040C 0.7 1.4 3.7
0.8 1.0 1.7 0.7 0.8 2.0 1.2 YFR045W 1.1 1.6 1.1 1.1 1.0 1.0 0.6 1.0
2.2 1.0 YIL170W 1.1 1.0 2.5 2.2 0.9 8.8 0.5 1.2 5.7 3.2 YKL192C 1.1
1.0 3.7 1.1 1.1 1.8 1.1 0.9 3.5 1.6 YKL209C 1.0 1.0 1.3 0.8 1.2 3.3
0.9 1.4 2.4 1.6 YKR106W 1.3 0.8 2.1 1.4 1.2 1.6 0.9 1.3 10.5 7.4
YMR056C 1.1 1.3 1.7 1.0 1.1 0.9 1.4 1.2 1.8 1.1 YPL147W 1.0 0.8 2.3
1.2 1.2 1.1 1.0 0.9 2.4 2.4 YIL166C 1.9 12.5 2.1 1.2 1.0 1.9 1.3
2.5 2.9 YMR058W 0.3 5.1 2.1 0.3 0.8 2.6 1.8 0.8 0.2 1.4 YNL142W 0.7
2.4 2.5 0.8 1.3 0.9 1.1 0.8 0.9 0.6 YDL210W 1.2 2.2 2.7 1.1 0.9 1.3
0.8 1.1 1.2 1.4 YCL025C 1.1 4.6 2.5 1.7 0.9 0.9 0.7 0.7 0.3 0.3
YJL212C 0.8 3.2 3.1 0.5 1.2 1.1 0.7 0.7 1.1 1.3 YBR132C 0.9 1.9 2.4
1.8 0.8 1.2 1.1 0.8 0.8 1.1 YBL030C 1.0 0.9 4.5 0.9 0.7 1.1 0.9 0.8
0.4 0.9 YCR024C-A 0.8 0.9 3.2 0.9 1.2 0.8 0.8 0.2 0.7 YDR342C 2.8
1.1 12.2 5.7 1.6 1.1 0.8 1.2 0.2 2.2 YDR343C 1.2 1.0 20.6 4.6 1.3
1.3 0.7 1.2 0.3 2.1 YEL027W 1.2 0.6 3.4 1.1 1.0 1.1 0.8 0.9 0.9 1.1
YHR094C 0.7 1.2 5.3 1.6 1.1 1.6 0.8 1.2 0.3 1.2 YHR175W 0.8 2.0 2.4
1.5 0.9 1.0 1.6 0.9 0.6 2.0 YIL056W 1.1 0.9 6.2 1.4 1.2 1.0 0.6 0.7
1.2 1.6 YMR203W 0.8 0.7 3.0 1.4 0.6 1.1 0.8 0.7 0.7 1.2 YBL099W 0.8
0.9 3.1 1.4 1.0 0.9 0.9 0.8 0.9 0.7 YBR127C 0.8 0.7 2.2 1.1 1.4 1.1
0.9 1.1 0.6 1.3 YDR038C 0.6 1.3 3.1 0.9 0.9 1.8 0.7 0.9 1.4 0.9
YDR039C 0.6 1.6 3.2 0.9 1.3 1.1 0.8 0.6 1.8 1.0 YDR298C 1.3 1.2 2.6
1.3 1.3 1.2 1.0 1.2 1.0 1.6 YDR345C 0.8 0.9 5.6 2.6 1.3 1.2 1.1 1.2
0.2 1.1 YEL063C 0.7 0.8 2.4 1.3 1.2 1.3 0.7 0.6 0.8 1.7 YFL011W 1.2
0.7 3.7 3.3 1.3 1.0 0.8 0.8 0.3 1.6 YGR082W 1.0 0.9 2.2 1.0 0.9 1.1
0.9 0.8 0.6 0.9 YGR191W 0.8 0.7 1.6 1.5 0.8 1.1 0.7 0.7 0.1 0.7
YGR260W 0.6 0.7 3.4 0.8 0.8 0.9 0.9 0.5 0.3 0.4 YHR026W 0.9 1.0 1.9
1.0 1.1 1.3 0.9 1.6 1.1 0.9 YJR077C 1.1 1.1 2.0 1.6 0.9 0.9 0.7 0.8
0.4 0.7 YJR121W 0.9 1.1 3.3 1.0 0.8 1.5 1.0 0.7 0.8 1.3 YLR081W 1.3
0.8 2.8 3.6 1.0 0.9 0.7 0.9 0.1 2.2 YMR011W 1.3 1.0 9.4 5.5 0.9 0.6
0.8 1.1 0.0 0.7 YOL156W 1.1 0.7 2.5 1.1 1.2 1.2 1.0 1.0 2.3 2.1
YPL036W 0.5 0.8 2.8 0.9 1.3 0.7 0.3 0.5 0.1 0.3 YGR096W 1.5 1.0 1.1
4.6 1.2 1.7 0.9 1.0 0.8 0.8 YIL006W 1.0 1.1 1.4 2.9 0.8 0.3 0.8 0.6
0.9 1.1 YKL016C 1.5 1.3 0.7 1.7 1.5 0.8 1.5 1.6 1.3 1.8 YKR067W 0.8
2.6 1.5 2.5 1.3 1.8 2.0 0.8 1.6 2.3 YMR162C 0.8 1.1 1.1 2.0 0.9 1.0
0.8 0.8 0.7 1.0 YOR348C 1.1 0.7 1.2 2.0 0.9 0.7 0.8 0.8 0.5 0.4
YPR192W 0.9 1.1 0.9 5.0 1.2 0.9 0.9 0.6 0.7 1.3 YPR194C 2.2 1.4 0.5
2.9 1.3 1.5 0.7 1.0 0.5 0.6 YDR086C 1.3 1.0 1.2 1.4 1.0 0.8 2.0 1.9
0.6 0.8 YGR224W 0.9 1.2 1.2 1.2 1.4 0.8 0.4 0.6 0.9 0.9 YDR387C 0.8
0.9 1.2 2.2 0.9 1.2 1.3 0.7 1.4 2.0 YFL050C 0.7 1.0 1.1 2.2 1.0 0.9
0.8 0.9 0.5 1.6 YBR298C 1.1 1.0 1.6 2.3 1.4 0.4 1.7 0.5 0.3 1.1
YLR295C 1.4 1.1 1.1 1.7 2.2 1.1 1.1 1.2 1.4 1.2 YNR072W 1.1 1.5 0.5
0.7 1.0 0.9 1.5 0.9 0.7 1.8 YOR316C 0.7 2.5 1.5 1.5 1.0 0.9 1.4 0.8
1.6 2.0 YOR328W 1.0 1.0 1.0 1.0 2.9 YPL134C 1.5 1.0 1.6 1.6 1.4 1.2
1.2 1.3 0.6 0.8 yeast The level of expressed mRNA in the absence of
chemical substance genes (11) (12) (13) (14) (15) (16) (17) (18)
Intensity YBR008C 9.4 0.8 2.0 4.1 0.8 3.1 2.0 1.2 0.37 YBR296C 1.5
1.6 2.0 2.3 1.7 0.3 3.8 4.0 0.54 YDR406W 1.4 3.9 7.7 0.5 0.8 5.5
2.7 5.6 0.53 YOR153W 1.0 4.0 11.8 0.3 3.6 1.6 2.5 3.1 1.91 YGR281W
0.7 2.4 12.9 0.9 2.1 1.1 2.8 3.1 1.04 YHL047C 1.0 2.6 3.8 0.5 1.1
2.3 1.2 1.2 0.74 YBR294W 1.2 1.0 3.1 1.3 1.0 0.9 1.0 0.9 0.18
YGL006W 0.8 0.9 4.5 0.9 1.1 1.7 2.4 4.1 1.37 YGR197C 1.1 1.2 2.4
1.5 1.0 1.5 1.7 1.9 0.37 YJL034W 1.3 1.6 6.1 0.6 7.9 0.6 1.1 1.0
4.58 YNL055C 1.9 1.7 2.4 0.9 1.1 2.6 1.2 1.7 4.10 YBR052C 1.7 1.3
2.1 1.5 0.7 3.1 1.8 3.1 2.77 YBR207W 1.1 0.9 2.2 0.9 1.4 1.4 1.2
1.4 1.39 YBR293W 1.1 1.0 3.0 1.4 3.1 1.6 1.0 0.9 0.94 YDL198C 2.5
1.2 2.0 1.7 1.2 1.4 1.5 1.1 1.19 YDL245C 1.5 1.0 2.0 1.2 1.8 1.5
1.0 1.1 0.28 YDR497C 0.7 0.9 2.7 0.6 10.1 1.6 1.8 1.45 YER053C 2.4
1.7 4.1 1.3 1.1 2.8 1.2 2.3 1.83 YFL041W 0.9 1.1 1.8 1.0 0.9 1.4
1.1 0.9 0.89 YGR055W 1.5 0.9 1.9 1.2 2.1 0.6 0.7 0.7 1.42 YJL219W
2.3 1.1 4.0 1.1 2.6 1.4 1.6 1.2 0.91 YJR106W 1.6 0.9 3.5 0.9 1.2
1.9 1.2 1.3 0.29 YKL146W 0.9 1.1 2.7 1.0 1.5 1.3 1.0 0.9 0.42
YLL028W 0.7 1.3 4.1 0.7 3.1 0.6 1.2 1.2 1.02 YLR348C 1.3 0.9 1.9
1.0 2.4 1.1 1.1 1.0 0.64 YOL119C 3.4 0.9 1.6 2.4 4.7 2.8 1.4 1.0
0.37 YOL163W 1.6 1.0 2.4 1.2 1.0 1.4 0.8 0.8 0.30 YOR035C 1.0 1.1
2.5 0.9 3.8 1.8 1.6 2.1 0.52 YOR130C 0.6 0.9 2.1 1.3 1.0 0.8 1.5
1.1 0.51 YOR273C 1.5 0.8 2.6 0.5 0.8 0.6 3.2 3.1 1.20 YOR332W 1.5
1.0 2.2 1.1 1.2 1.2 1.3 1.7 3.58 YCR098C 1.3 1.3 1.4 1.1 11.0 0.8
1.7 1.6 0.22 YGR138C 0.7 0.6 0.6 0.9 4.5 0.7 0.7 0.7 1.24 YBR295W
1.1 0.9 1.8 1.1 4.8 1.4 1.3 1.2 0.27 YGL255W 0.5 0.7 0.2 1.0 2.6
0.5 0.6 0.5 1.36 YHL035C 0.9 1.4 1.1 0.8 3.1 2.4 1.1 1.2 0.77
YIL022W 1.0 0.9 1.2 0.6 2.9 1.1 0.8 0.7 0.52 YLR378C 1.0 1.2 1.6
0.4 5.9 0.4 0.9 0.7 1.23 YCL038C 2.0 1.3 1.9 1.3 2.0 1.8 1.4 1.5
1.04 YFL054C 1.7 1.2 2.3 0.9 1.4 1.3 1.7 1.4 1.06 YHL040C 1.7 2.0
2.0 1.1 3.4 1.0 1.4 1.0 0.69 YKR039W 1.9 1.5 1.3 1.2 1.7 1.9 0.9
1.1 0.40 YPL271W 1.7 0.8 1.2 1.3 0.8 1.4 1.2 1.3 1.34 YBR068C 0.8
0.8 2.2 1.8 1.6 5.5 1.1 1.3 1.99 YCR037C 0.8 0.7 1.3 0.8 1.0 1.1
1.4 0.9 0.74 YDL128W 1.2 0.9 1.6 0.7 1.1 1.0 0.9 1.0 2.80 YDR270W
1.0 1.0 1.8 1.0 1.4 1.1 0.9 0.7 0.38 YEL065W 0.6 1.7 0.8 0.4 2.2
2.6 0.7 0.6 2.10 YGL008C 0.7 2.4 1.9 1.2 1.0 2.1 1.1 1.0 4.08
YGL104C 1.8 1.1 2.0 1.0 0.9 1.7 1.3 1.3 0.58 YGL167C 0.8 1.1 1.5
0.8 1.3 1.3 1.4 1.4 1.41 YGR065C 1.1 0.5 0.8 1.3 1.2 1.1 0.7 0.7
0.68 YHR092C 1.5 1.0 0.5 1.6 0.2 1.2 0.9 1.3 6.09 YIL088C 1.8 0.9
1.5 1.2 1.2 1.8 1.2 1.4 1.89 YNL259C 1.6 0.7 1.1 1.4 0.7 1.7 2.6
2.4 1.22 YOR270C 1.5 0.7 1.3 0.7 1.1 0.8 0.9 0.9 3.49 YPL265W 1.8
0.9 1.1 1.1 1.2 2.0 0.5 0.4 1.42 YPR124W 2.0 0.8 0.6 0.4 1.1 2.4
1.0 1.3 2.57 YER119C 2.2 0.7 1.6 1.0 2.3 0.8 1.0 0.9 0.32 YFL055W
2.7 0.9 1.3 1.5 0.7 1.4 1.4 1.0 0.23 YLL055W 3.6 0.7 1.5 1.3 0.7
2.8 1.1 1.3 0.47 YHL036W 2.3 1.2 1.5 1.2 0.9 1.1 1.0 1.0 0.60
YHR048W 2.0 0.9 1.1 1.7 0.9 1.4 0.7 0.9 0.26 YKL221W 1.9 0.7 1.6
1.4 1.1 1.3 0.8 0.9 0.27 YLR092W 3.1 1.0 1.8 1.4 0.9 1.2 1.0 1.1
0.24 YML116W 4.3 0.5 0.8 2.0 1.9 1.0 1.0 1.0 0.94 YBR291C 1.1 0.9
1.0 1.7 0.5 1.5 0.9 1.3 1.19 YCL069W 1.0 0.9 0.8 1.3 1.4 0.9 1.0
1.0 0.25 YJR095W 0.6 0.7 0.8 1.3 0.8 0.8 1.3 0.9 0.23 YKL188C 1.1
1.2 1.2 2.1 1.4 2.7 1.1 1.5 0.27 YKL217W 1.6 0.8 1.2 1.2 2.2 3.0
1.7 3.3 0.29 YKR105C 0.0 0.8 2.5 1.2 1.5 0.7 0.8 1.0 0.26 YOL158C
0.7 0.9 1.4 1.0 0.9 1.2 1.4 1.7 1.30 YPL224C 0.8 1.1 1.3 1.4 1.0
2.5 1.3 1.9 0.64 YPR201W 2.2 0.7 1.1 1.8 0.8 0.9 0.8 0.9 0.29
YAL067C 1.2 1.0 1.1 1.3 2.4 1.6 1.0 1.0 0.33 YDL149W 1.2 0.7 1.5
1.2 1.8 1.4 0.8 1.0 0.33 YJL094C 1.1 1.2 2.6 1.0 1.0 1.8 2.1 2.0
0.84 YLL061W 1.7 0.7 0.9 1.3 1.4 1.0 0.6 0.7 0.33 YPL274W 2.0 0.5
0.6 0.9 1.5 1.1 0.7 0.6 0.41 YBR241C 1.4 1.4 1.4 0.9 1.6 0.7 1.0
1.2 1.25 YDL206W 0.6 1.0 1.3 1.0 1.1 3.1 1.0 1.1 0.35 YDR040C 0.8
0.9 1.8 0.9 0.8 1.4 1.4 1.6 1.25 YFR045W 1.4 1.0 1.1 1.0 1.1 0.6
0.9 0.8 0.84 YIL170W 1.7 0.7 1.9 1.1 2.3 1.8 1.6 1.5 0.48 YKL192C
1.1 1.2 1.7 1.5 1.2 2.1 1.0 0.8 1.57 YKL209C 0.8 0.9 1.4 1.1 1.0
1.1 1.1 1.0 0.30 YKR106W 1.8 0.8 1.4 1.7 2.8 0.9 0.8 0.16 YMR056C
1.6 0.9 0.9 1.1 0.7 2.4 1.0 1.1 0.72 YPL147W 1.3 0.9 1.5 1.0 2.4
2.5 1.5 3.6 0.33 YIL166C 1.8 0.9 1.5 1.1 1.3 0.7 1.2 0.9 0.26
YMR058W 0.8 0.8 0.4 0.3 0.5 0.4 0.6 0.5 1.66 YNL142W 0.9 1.2 0.9
0.8 0.3 1.0 1.0 0.9 0.44 YDL210W 0.6 0.8 1.2 1.1 1.9 0.9 1.1 0.9
0.20 YCL025C 1.0 1.1 0.5 0.7 0.8 0.6 0.6 0.6 1.98
YJL212C 0.9 0.4 1.0 0.8 0.3 0.5 0.6 0.5 0.59 YBR132C 1.9 1.0 1.4
1.1 1.5 1.3 1.1 1.3 0.43 YBL030C 1.1 0.9 0.5 0.8 1.8 1.0 1.0 1.1
3.12 YCR024C-A 1.5 1.0 0.5 0.8 1.3 1.5 0.9 1.4 4.02 YDR342C 2.9 1.0
0.6 0.9 0.5 2.4 1.0 2.2 5.23 YDR343C 2.3 1.0 0.8 0.8 0.5 2.8 1.1
2.3 5.81 YEL027W 0.9 0.9 0.7 1.4 1.5 1.6 1.0 1.4 4.75 YHR094C 0.6
0.9 0.7 0.6 2.7 0.9 1.4 1.4 4.82 YHR175W 1.1 1.4 1.2 0.7 1.3 2.3
1.3 1.2 1.01 YIL056W 0.7 1.0 1.5 1.0 0.5 0.9 1.5 1.2 0.71 YMR203W
2.3 0.7 1.1 0.7 1.2 0.9 0.8 0.7 1.62 YBL099W 2.1 1.0 0.9 0.6 1.0
0.9 0.7 1.2 3.49 YBR127C 1.1 0.9 0.9 0.6 1.3 1.4 0.8 1.0 4.59
YDR038C 0.9 0.7 2.0 0.8 0.8 1.4 1.3 1.5 1.32 YDR039C 0.9 0.8 1.8
0.9 1.2 1.4 1.1 1.6 1.39 YDR298C 1.2 1.1 1.2 1.5 0.8 2.0 1.1 1.6
2.69 YDR345C 1.5 1.4 1.2 0.8 0.8 1.0 1.3 1.8 5.65 YEL063C 0.8 1.1
1.1 0.8 1.3 1.0 0.7 0.7 1.12 YFL011W 2.1 0.9 0.8 0.8 1.7 1.2 0.8
1.0 1.25 YGR082W 1.3 0.8 0.5 0.9 1.2 1.3 0.9 0.8 1.47 YGR191W 1.6
0.7 1.0 0.7 1.5 0.7 0.8 0.8 1.58 YGR260W 1.3 0.6 0.5 0.7 1.8 1.0
0.9 0.9 1.71 YHR026W 1.4 0.7 0.7 1.3 2.4 1.2 0.9 1.1 3.40 YJR077C
1.6 1.0 0.9 0.7 1.5 0.7 1.0 0.8 1.79 YJR121W 0.9 0.8 1.0 0.7 0.9
1.2 1.1 1.4 3.99 YLR081W 2.6 1.0 0.6 1.0 0.7 1.2 0.7 0.9 1.46
YMR011W 1.5 0.8 0.4 0.6 0.6 1.2 1.3 1.6 4.95 YOL156W 1.1 0.9 1.7
0.9 1.9 0.9 0.9 0.9 0.53 YPL036W 0.8 0.5 0.3 0.6 1.0 0.7 0.4 0.5
3.66 YGR096W 0.8 0.8 1.1 1.2 0.9 0.8 0.8 1.0 0.49 YIL006W 1.0 0.9
0.8 1.0 1.5 1.7 0.8 0.9 0.28 YKL016C 1.3 1.0 1.3 1.6 0.7 1.8 1.0
1.7 2.08 YKR067W 1.3 1.0 1.3 1.3 1.3 2.0 0.8 1.0 0.58 YMR162C 1.7
0.7 0.9 1.0 1.0 0.8 0.8 1.1 0.32 YOR348C 1.1 0.7 1.1 1.2 1.6 1.7
0.9 0.9 0.18 YPR192W 0.7 0.5 1.1 0.7 1.7 2.6 1.6 0.9 0.28 YPR194C
0.7 0.7 1.0 1.0 0.4 0.8 1.0 0.9 0.27 YDR086C 1.1 0.7 0.7 1.5 2.1
1.3 1.4 1.9 2.60 YGR224W 0.8 0.6 0.8 0.9 1.1 1.0 2.8 1.3 0.27
YDR387C 2.0 0.9 1.3 0.9 1.4 2.7 1.2 1.1 0.86 YFL050C 1.2 0.9 1.2
1.0 1.4 2.3 0.8 1.0 0.36 YBR298C 1.5 1.1 0.8 0.9 0.2 2.1 0.9 0.8
0.88 YLR295C 1.3 0.5 0.8 1.2 0.5 2.4 0.9 1.5 1.07 YNR072W 1.4 1.0
1.5 1.0 1.8 2.1 1.3 1.0 0.26 YOR316C 2.4 1.1 1.6 1.0 1.5 2.2 0.8
1.0 0.93 YOR328W 1.1 1.8 0.8 3.3 2.1 0.19 YPL134C 1.7 0.8 1.0 1.4
1.1 3.3 1.3 1.3 0.70
[0030] TABLE-US-00007 TABLE 6 Stress protein genes The level of
expressed mRNA in the presence of chemical substance/The level of
expressed mRNA in the absence of chemical substance yeast genes (1)
(2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16)
(17) (18) Intensity YBR072W 18.5 17.4 18.4 10.5 1.2 32.2 6.6 2.1
29.4 43.4 6.3 16.3 38.5 5.8 4.9 23.1 1.8 2.2 0.59 YFL014W 3.4 5.1
5.7 11.0 1.0 9.3 5.5 3.4 13.1 5.8 5.0 4.3 15.2 7.3 6.3 14.2 1.5 8.8
2.14 YLL060C 12.5 4.2 2.3 2.6 0.9 1.4 2.0 5.8 13.0 23.2 14.1 1.1
1.8 10.6 1.5 3.6 1.9 2.3 0.57 YAL005C 0.6 1.6 7.0 0.9 1.2 1.6 1.2
0.9 3.9 1.8 1.0 1.2 5.0 0.4 1.6 0.7 0.8 0.5 5.23 YBL075C 1.3 4.3
3.1 1.6 1.1 0.8 1.3 0.8 60.3 6.7 1.6 1.1 8.0 1.1 2.6 2.2 1.2 0.7
1.17 YBR169C 1.0 2.1 3.9 1.9 0.8 4.9 2.5 0.9 7.0 4.3 2.2 1.7 7.2
1.1 1.6 2.4 1.3 1.6 1.10 YCL035C 2.0 2.3 1.5 1.7 1.5 5.1 2.7 1.4
1.9 2.3 2.1 1.5 2.8 2.5 1.9 5.5 2.6 4.2 1.74 YCR060W 0.7 0.9 0.8
3.3 2.4 1.2 0.7 1.1 1.2 1.7 8.6 1.7 3.3 1.2 1.7 1.04 YDR155C 1.1
1.5 3.2 1.8 0.8 1.5 1.2 1.4 1.3 1.3 3.8 1.4 3.3 1.0 2.5 1.6 1.2 2.5
4.99 YDR258C 1.6 2.3 2.8 1.4 1.3 2.4 3.9 1.9 4.9 13.3 1.7 1.8 5.2
1.5 0.6 1.0 1.3 1.3 0.87 YER103W 0.7 2.1 5.2 2.1 1.1 1.7 1.0 0.9
20.3 9.0 1.8 1.9 9.0 0.9 3.2 1.2 1.4 0.6 2.10 YKL210W 0.5 1.7 2.7
0.7 0.8 1.4 1.0 0.9 3.5 2.9 1.4 1.3 2.9 0.8 1.0 0.9 0.7 1.1 2.29
YLL024C 0.5 1.6 5.3 0.8 0.7 1.0 1.1 0.7 2.8 2.4 1.6 1.0 4.8 0.4 1.3
0.5 0.5 0.6 5.12 YLL026W 1.8 2.9 7.7 1.7 0.9 1.9 2.9 1.4 11.4 6.6
1.7 1.9 8.1 0.8 0.9 1.6 1.7 2.5 2.56 YNL160W 2.1 3.7 10.6 2.0 1.3
5.8 2.4 1.2 3.5 2.7 5.4 1.4 6.0 1.3 0.7 4.0 1.0 1.0 1.77 YNL241C
1.3 2.5 4.3 1.0 0.8 0.9 3.2 0.9 3.4 7.4 3.0 2.0 4.9 1.1 7.0 2.8 1.0
1.0 0.68 YOR027W 0.7 2.4 4.4 0.8 1.0 1.6 1.3 0.9 3.5 4.0 1.3 1.3
5.1 0.8 1.4 0.6 0.9 0.8 1.52 YPL240C 0.7 1.4 2.4 0.9 1.3 1.2 1.4
1.2 3.5 2.6 1.0 0.8 2.9 0.7 1.2 0.7 0.8 1.0 4.83 YDR293C 0.9 0.9
1.2 1.4 0.6 0.9 0.9 0.6 1.2 1.2 1.1 0.9 2.3 0.8 1.7 1.6 1.4 1.3
1.12 YDR436W 0.9 0.9 1.1 1.4 0.7 1.1 1.2 0.9 3.5 1.1 2.0 0.9 2.7
1.2 0.8 1.4 0.9 1.2 0.53 YDR519W 1.3 3.2 1.7 1.6 0.7 1.3 1.9 1.4
0.5 1.2 1.2 1.7 2.5 1.3 2.0 1.5 1.8 2.4 2.01 YEL030W 0.7 0.9 1.9
1.1 0.4 0.6 0.9 0.7 2.3 2.5 1.7 0.9 2.7 0.7 0.8 0.8 0.9 0.6 1.28
YER125W 0.6 1.1 1.5 0.9 1.4 0.7 0.8 0.7 0.6 1.2 1.0 0.7 1.9 0.7 0.8
1.0 1.0 1.0 1.48 YFL016C 0.8 1.0 1.6 0.9 1.3 1.3 1.4 0.7 6.4 2.9
1.2 1.0 2.8 0.8 0.8 0.6 1.2 0.9 1.25 YFR052W 1.1 1.6 1.3 1.5 1.4
3.2 2.2 1.5 3.7 3.0 0.9 1.8 3.8 3.3 1.4 2.7 1.2 1.9 1.62 YHR057C
1.1 1.2 0.7 0.9 1.3 1.3 1.3 1.0 2.6 1.2 1.6 1.1 1.9 1.9 1.2 2.2 1.6
1.3 1.07 YIR037W 1.4 2.2 2.0 2.3 0.6 2.7 1.8 1.3 6.2 3.8 3.0 1.3
2.4 2.3 1.0 4.0 1.7 2.9 1.97 YIR038C 1.3 3.5 4.6 2.0 0.7 2.5 2.0
1.3 4.6 4.5 3.4 1.1 2.5 2.5 1.2 6.0 2.8 2.0 1.11 YJR045C 0.5 1.9
3.9 0.5 1.2 1.0 0.8 3.2 3.0 1.4 1.0 2.3 0.5 2.3 0.8 0.7 0.9 3.78
YLL039C 1.1 1.0 1.7 1.2 0.9 1.5 1.1 1.1 3.4 1.5 1.1 1.0 2.2 1.4 3.0
1.1 1.6 2.1 3.60 YLR259C 0.7 1.0 3.1 1.6 1.1 0.9 1.8 0.8 1.8 2.6
3.0 0.7 2.5 0.8 2.1 1.3 0.8 1.0 2.09 YML070W 0.9 1.7 2.5 1.9 1.4
2.2 3.1 1.3 4.5 3.9 1.5 1.3 3.3 1.3 0.9 2.6 1.2 1.3 1.03 YPL106C
0.6 1.7 2.4 1.1 1.2 1.6 1.1 1.2 4.9 1.8 1.3 1.1 3.1 0.9 1.1 0.5 0.5
0.5 3.34 YPR026W 0.9 1.2 5.0 1.3 0.8 1.3 1.0 0.9 3.1 1.6 1.2 2.3
1.5 3.1 2.5 0.9 1.3 0.26 YDR077W 1.2 1.0 3.5 2.1 0.8 1.0 0.7 0.8
0.7 0.7 6.8 0.8 1.0 0.3 6.1 1.0 1.4 1.1 4.77 YKL163W 1.1 1.4 3.4
1.9 0.6 1.1 0.9 0.8 0.7 1.6 1.3 0.9 1.5 0.5 16.8 3.0 0.8 1.0 2.01
YLR109W 0.8 2.9 6.0 0.9 1.3 2.1 2.6 0.9 2.4 2.7 1.5 1.6 3.2 2.3 3.9
1.8 1.1 1.2 3.86 YOR208W 1.3 1.0 1.2 2.9 1.4 1.8 1.1 1.0 1.5 2.0
1.2 1.2 1.5 1.3 4.4 1.9 1.6 1.6 0.56 YDR098C 0.8 1.4 1.0 0.8 1.5
1.1 1.5 1.2 3.7 1.5 1.4 1.3 1.2 1.5 2.2 0.8 1.0 1.2 1.59 YHR030C
2.1 0.8 0.6 2.9 1.8 0.9 1.8 1.5 0.6 2.5 1.5 0.7 1.0 1.1 3.4 1.4 2.0
1.8 1.05 YJL159W 1.0 1.3 2.8 1.1 1.0 1.8 0.9 0.8 0.5 1.2 1.2 1.0
1.7 0.6 5.3 1.0 1.4 0.9 2.45 YMR173W 1.5 3.6 3.0 0.9 1.1 5.0 2.4
2.3 2.7 8.2 3.2 1.4 2.0 2.3 2.5 1.2 1.9 1.8 1.37 YCR021C 5.2 1.4
4.2 8.6 0.9 2.2 0.9 0.8 2.2 1.0 0.6 0.5 0.9 1.6 0.5 0.6 0.7 0.8
1.36 YDL022W 0.9 2.6 6.9 1.5 0.7 2.1 1.5 0.8 1.2 1.8 2.8 1.2 1.5
0.8 0.9 1.1 1.0 1.4 1.79 YDR033W 1.1 1.3 4.6 1.5 1.1 6.7 0.8 1.0
0.3 1.0 0.7 1.0 0.7 1.0 0.8 1.0 0.7 1.0 5.78 YFL020C 1.0 1.1 1.9
1.2 1.1 2.0 1.4 0.7 1.3 1.4 1.2 1.3 1.4 1.0 1.4 0.9 1.5 0.9 0.70
YGL073W 1.0 2.1 0.9 1.0 1.7 1.9 1.3 0.8 1.9 2.4 0.8 0.8 1.5 1.2 0.9
1.1 2.5 1.2 0.66 YIL033C 0.8 1.3 3.3 1.3 0.7 2.0 1.1 0.7 2.4 1.3
1.8 1.1 2.5 0.7 1.0 2.0 1.0 1.2 1.18 YMR021C 1.0 0.7 0.9 1.1 1.6
2.2 2.5 1.3 0.6 1.3 0.9 0.8 1.4 1.3 1.0 2.0 3.3 3.4 1.14 YBR126C
0.8 1.9 5.6 1.2 0.7 2.9 2.3 0.6 1.7 1.1 1.3 2.1 0.7 1.0 1.7 1.5 1.3
1.96 YBR067C 1.6 2.5 2.8 0.9 1.1 1.1 1.1 1.1 1.7 1.0 3.1 1.0 0.9
0.7 3.3 2.5 0.5 0.4 1.76 YDR513W 2.2 2.5 2.3 2.6 0.9 2.1 1.6 1.6
4.6 3.1 2.0 0.9 1.8 2.0 1.3 3.8 1.3 3.2 3.10 YGR088W 1.3 1.2 7.7
2.4 1.0 1.3 0.8 0.8 1.5 3.2 3.9 1.1 1.2 1.3 0.7 5.6 0.9 2.0 0.75
YHR104W 1.0 4.1 15.7 1.9 1.1 1.2 1.5 1.1 4.8 2.3 2.6 1.0 1.2 1.5
1.6 1.3 1.9 1.9 1.57 YKL161C 4.2 0.8 0.9 2.2 1.4 2.0 2.0 1.9 1.4
1.7 3.1 0.9 1.3 1.4 1.3 1.1 1.4 1.9 0.45 YPL223C 4.8 20.0 1.2 5.1
0.9 1.5 1.1 1.2 29.4 16.5 1.8 0.9 2.3 2.5 1.5 19.0 1.0 1.3 0.31
YBR054W 1.9 1.8 5.4 1.7 0.8 1.1 0.6 2.1 0.4 1.2 1.8 0.7 1.5 1.0 0.6
0.4 0.7 0.7 3.02 YAL015C 1.2 1.1 1.7 1.9 1.1 0.7 1.2 1.1 4.0 2.7
1.4 1.0 1.2 1.6 0.7 2.0 1.1 1.2 0.61 YDL025C 1.7 5.0 3.5 1.5 0.6
0.6 1.0 1.1 3.6 4.5 1.5 0.9 1.2 1.7 1.0 1.7 1.0 1.4 0.56 YML007W
0.9 0.8 0.9 1.3 1.0 0.5 1.1 1.9 2.1 2.5 1.3 1.1 1.7 1.2 1.0 1.4 1.0
1.4 1.54 YER042W 3.0 2.2 3.1 1.0 1.1 1.6 1.1 1.7 6.8 2.1 1.8 1.1
1.4 5.2 1.0 1.9 0.7 1.1 1.80 YOL064C 1.4 2.1 1.1 0.6 0.9 1.4 1.2
1.0 8.7 2.7 1.0 0.9 2.0 0.9 1.0 1.7 1.2 1.3 1.32 YGL181W 0.9 0.9
1.2 1.1 1.1 1.9 1.3 1.2 2.7 2.3 1.2 1.0 2.8 1.0 1.5 1.3 1.0 1.3
0.98 YJL128C 0.8 1.4 0.4 0.8 1.2 1.3 1.8 0.9 2.0 1.7 0.6 1.0 1.7
0.8 1.2 0.9 1.0 1.0 0.42 YJL165C 1.0 0.8 1.3 1.6 1.1 0.5 0.8 0.7
2.8 1.0 1.7 0.9 1.5 0.9 1.0 1.5 1.3 1.8 0.87 YJR090C 0.8 1.0 0.6
0.8 1.2 1.2 0.8 0.8 1.9 1.2 0.4 0.8 2.2 1.0 1.6 0.8 1.1 1.0 0.60
YMR186W 0.6 1.4 2.0 0.9 1.3 1.3 1.2 0.8 2.6 1.3 1.1 1.0 2.4 0.6 1.3
0.6 0.7 1.1 6.64 YNL064C 0.9 1.8 1.8 1.1 0.9 0.8 0.6 1.4 2.4 1.8
0.9 0.8 1.1 0.8 0.7 0.3 0.7 0.7 3.79 YOR008C 0.7 0.8 1.4 1.1 1.4
1.1 0.8 0.8 1.9 1.0 1.0 0.7 0.9 0.9 0.9 1.2 0.8 1.3 1.75 YPL194W
0.9 1.4 0.4 1.1 1.3 1.1 1.5 1.3 9.6 3.1 0.9 0.9 1.4 1.1 1.4 0.9 1.0
0.8 0.22 YBL093C 1.0 2.0 0.4 1.4 1.0 0.8 1.3 1.6 0.7 1.1 1.3 1.1
2.1 1.0 0.5 0.9 1.4 1.3 1.47 YKR053C 0.9 2.0 1.0 1.2 1.0 1.1 1.7
0.9 0.8 1.8 0.5 0.7 0.7 1.3 0.3 0.9 2.8 2.4 0.35 YJL158C 0.9 0.6
2.8 1.5 1.4 0.5 0.4 0.7 0.2 0.5 1.9 1.1 0.4 0.5 1.7 0.6 1.4 1.4
3.48 YER057C 1.2 2.0 3.0 1.8 0.8 1.6 1.4 1.0 0.6 1.4 1.8 1.5 1.0
1.4 1.7 2.8 1.1 1.8 2.03 YHL046C 1.1 1.7 2.1 1.3 0.9 0.8 1.3 1.0
1.0 2.1 0.4 1.1 1.4 1.4 1.0 1.4 0.9 0.9 0.55 YIL011W 0.7 0.5 3.9
0.6 1.1 0.7 0.6 0.7 0.0 0.5 2.5 0.6 0.5 0.5 0.9 1.0 0.8 0.8 0.57
YKL164C 0.6 1.1 2.5 0.9 1.1 1.4 0.8 0.8 0.4 0.7 1.0 0.8 0.9 0.3 1.2
1.1 0.8 0.8 2.75 YNR076W 1.3 1.3 2.5 1.0 1.2 1.2 1.2 1.0 1.3 2.5
1.4 0.7 0.9 0.8 1.1 0.8 1.5 0.8 0.42 YOL161C 1.2 1.1 2.4 1.4 0.9
1.0 0.9 0.8 0.7 2.0 1.5 1.3 1.2 0.9 1.1 1.6 1.1 1.0 0.89 YOR009W
0.9 0.8 3.2 0.7 0.8 0.9 0.6 0.7 0.4 0.5 1.4 0.4 0.4 0.7 0.6 0.8 0.9
0.8 0.36 YOR010C 0.7 0.7 3.2 0.6 1.2 0.5 0.4 0.5 0.6 0.7 1.2 0.5
0.5 0.4 0.6 1.1 1.4 0.6 0.61 YPL059W 1.2 0.9 2.6 1.3 1.2 1.3 0.7
1.4 2.0 1.3 1.6 0.8 0.7 1.3 1.0 2.1 1.8 1.3 1.35 YBR044C 0.8 1.4
0.7 1.9 1.4 1.0 1.5 1.1 0.8 1.2 1.1 0.8 1.2 0.9 0.9 1.4 0.9 1.3
0.57 YEL039C 1.1 0.7 1.3 5.1 0.9 1.5 0.6 1.1 1.2 1.2 1.7 0.6 0.5
1.4 0.4 3.5 0.7 1.1 1.59 YGL115W 0.9 0.6 1.2 2.0 1.2 1.2 1.4 1.0
1.2 1.2 1.0 0.9 0.7 1.2 0.7 1.7 0.8 1.2 2.46 YLR006C 0.7 0.7 0.9
6.2 1.6 0.9 1.1 0.9 1.1 1.1 1.5 0.7 0.8 1.0 0.9 0.8 1.6 1.0 0.40
YPR005C 1.3 0.8 1.5 3.8 1.0 0.8 1.2 1.2 2.8 2.0 0.4 0.6 0.7 1.3 2.7
0.8 1.0 1.1 0.24 YHL028W 0.7 0.8 1.4 0.5 1.1 1.8 2.1 0.4 0.2 0.4
0.7 1.5 2.1 1.3 0.6 2.6 1.6 2.5 0.62 YCR083W 1.1 2.8 1.5 1.8 1.6
2.4 1.8 1.5 1.8 1.8 1.8 1.1 1.8 2.4 1.0 3.1 1.3 1.3 0.98 YPL140C
0.9 1.3 0.9 1.0 0.8 0.3 1.4 1.1 0.9 0.9 0.8 0.8 0.9 1.1 0.7 1.8 0.9
1.4 0.46
[0031] TABLE-US-00008 TABLE 7 Metabolism protein genes The level of
expressed mRNA in the presence of chemical substance/The level of
expressed mRNA in the absence of chemical substance In- yeast genes
(1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15)
(16) (17) (18) tensity YCR107W 12.0 2.6 1.8 1.6 0.7 1.5 1.5 15.6
196.6 34.0 23.0 0.9 4.0 8.3 4.8 3.1 1.3 1.1 0.59 YDL243C 14.4 2.7
2.4 1.0 1.1 2.2 1.6 11.8 64.2 29.6 19.6 1.1 4.1 12.0 4.2 3.0 1.8
1.5 0.76 YFL014W 3.4 7.2 5.7 11.0 1.0 9.3 5.5 3.4 13.1 5.8 5.0 4.3
15.2 7.3 6.3 14.2 1.5 8.8 2.14 YFL056C 19.0 2.3 2.3 1.5 0.9 0.6 1.4
18.5 162.3 31.3 68.3 1.0 4.7 7.8 5.0 3.4 1.0 1.1 0.55 YFL057C 20.9
5.8 1.5 1.8 0.9 1.2 1.8 18.0 51.8 46.1 27.7 1.0 4.1 23.4 3.1 3.9
1.6 1.3 0.71 YJR155W 10.6 3.7 1.4 2.5 0.7 1.4 1.7 10.6 38.2 18.8
15.4 1.0 5.7 9.4 2.6 5.6 1.3 1.4 0.64 YNL331C 8.6 3.6 1.3 1.0 1.6
1.8 1.9 13.1 42.6 36.3 21.8 0.9 3.1 7.5 2.3 4.0 1.7 1.3 0.58
YNL332W 1.1 1.5 1.1 2.0 1.6 1.1 2.1 1.5 3.3 2.1 2.6 1.2 2.1 3.0 5.4
2.2 1.0 1.0 0.24 YOL165C 10.1 4.5 1.8 0.9 0.9 1.7 1.4 17.8 46.9
23.3 17.6 0.8 3.7 9.1 3.0 1.8 1.6 1.0 0.69 YPR167C 5.3 5.8 1.9 0.8
1.4 2.6 1.2 5.5 76.6 9.0 1.9 1.3 1.9 4.2 0.9 0.9 1.7 1.4 0.54
YBR256C 3.0 1.4 0.6 1.3 1.6 2.0 2.1 2.3 18.1 6.8 3.2 1.7 3.5 5.6
1.6 3.0 2.6 3.3 1.97 YBR296C 7.0 11.2 2.2 2.5 1.4 1.4 0.2 1.1 0.4
1.8 1.5 1.6 2.0 2.3 1.7 0.3 3.8 4.0 0.54 YDL021W 4.8 1.7 2.4 3.7
1.7 6.5 5.9 2.7 2.5 7.4 4.7 2.4 5.3 3.7 0.7 7.3 1.9 3.2 0.47
YFL061W 1.5 1.4 2.1 3.0 1.0 0.5 1.2 1.2 3.2 9.9 1.1 0.9 1.2 6.0 2.1
1.0 1.2 0.9 0.31 YGR043C 2.5 4.7 3.2 7.9 0.9 16.3 6.5 2.6 10.9 8.4
3.6 3.3 6.9 4.1 3.0 13.7 1.6 4.8 0.66 YHR112C 1.8 3.1 0.7 1.4 1.3
2.9 3.4 1.7 10.5 4.4 1.5 1.9 3.9 2.4 2.0 2.7 1.6 1.8 0.55 YIR030C
1.4 1.0 0.9 1.3 0.9 0.5 1.2 1.4 5.4 2.1 1.4 0.9 1.3 2.9 0.7 0.8 0.9
1.0 0.42 YJR010W 9.1 7.3 4.9 0.8 1.1 2.5 1.4 3.1 30.0 11.1 2.9 1.4
3.2 5.4 1.7 1.7 1.2 1.0 0.56 YKL001C 6.8 21.4 5.6 1.8 0.8 0.9 1.1
3.4 10.3 3.4 2.6 2.1 1.6 6.2 1.1 1.8 2.7 1.7 0.91 YKR097W 1.3 2.4
1.3 3.3 1.1 1.7 3.7 2.5 1.9 3.3 0.8 1.8 17.5 2.1 2.5 2.2 1.1 1.5
0.16 YLR303W 7.3 9.8 12.1 1.1 1.1 3.0 3.6 5.3 18.6 5.6 9.8 4.3 9.9
3.8 5.8 3.4 1.5 1.4 1.42 YNL274C 1.4 18.7 2.6 1.9 0.7 4.2 2.0 2.3
6.3 5.3 4.0 1.1 2.3 3.3 2.5 6.4 1.4 2.6 0.85 YOL151W 6.7 3.8 9.1
1.3 1.3 8.4 4.4 6.7 22.8 17.0 9.0 4.6 16.9 4.0 2.8 3.7 4.0 5.6 1.12
YOR226C 1.3 2.2 1.7 1.1 1.3 1.2 1.2 1.2 1.3 5.9 1.5 0.6 0.9 2.7 1.0
0.7 1.0 0.7 0.58 YJL153C 1.3 1.7 1.7 17.6 0.7 0.8 2.3 1.3 3.9 2.5
0.7 10.2 38.0 1.4 37.0 1.0 6.5 1.8 0.27 YOR153W 1.6 0.9 5.1 1.1 1.0
7.4 2.6 0.5 3.2 1.2 1.0 4.0 11.8 0.3 3.6 1.6 2.5 3.1 1.91 YPL088W
3.3 1.3 0.6 2.5 1.5 7.1 3.7 1.9 0.6 2.8 1.1 3.6 4.8 1.6 3.2 4.3 9.1
8.3 0.69 YDL124W 2.1 8.5 5.7 1.7 0.7 3.4 2.9 2.1 3.3 5.3 3.4 2.4
6.0 1.6 3.4 3.6 2.2 2.6 2.43 YDL174C 0.9 1.8 0.9 1.3 0.5 1.7 3.6
0.8 0.5 1.7 0.9 2.8 5.9 1.1 0.6 5.1 2.2 4.0 0.63 YGL156W 1.3 2.5
1.8 2.2 1.4 2.1 2.1 1.4 5.6 2.4 2.1 2.6 6.0 1.6 3.0 4.1 1.4 1.9
0.29 YGR157W 1.0 0.9 5.2 0.8 1.2 1.0 0.8 0.7 3.3 2.0 1.0 1.8 4.8
0.7 4.6 1.0 0.8 1.3 2.10 YHR043C 1.3 1.8 1.2 1.7 0.9 2.2 2.9 3.0
1.2 1.0 1.6 2.2 2.7 1.3 2.1 2.2 1.4 1.7 1.38 YHR044C 1.3 1.3 1.7
1.5 1.2 3.3 2.6 2.0 1.1 1.1 1.7 2.3 4.3 1.3 1.5 2.4 1.3 1.4 1.12
YJR073C 1.1 2.4 2.7 2.7 0.6 2.2 2.9 1.0 6.8 2.8 2.8 4.1 10.0 2.3
28.9 3.7 2.9 2.6 0.99 YOR303W 1.1 2.2 0.5 1.0 1.2 1.8 1.2 1.6 0.9
5.2 0.9 1.9 3.3 1.6 4.1 1.2 1.2 0.8 1.47 YBR294W 6.3 12.0 0.9 2.6
1.4 1.2 1.1 1.0 5.2 5.2 1.2 1.0 3.1 1.3 1.0 0.9 1.0 0.9 0.18
YCL043C 0.6 3.7 2.5 0.7 0.9 1.3 1.0 0.8 1.6 1.2 1.7 1.5 4.1 0.6 5.7
0.8 0.9 1.0 2.37 YCL050C 1.0 1.1 1.9 0.7 1.4 1.2 1.2 1.2 3.0 2.9
1.3 1.2 2.8 1.2 0.8 0.7 1.0 1.0 2.20 YCR012W 1.1 1.5 5.1 1.2 1.1
2.5 1.4 0.8 1.4 1.5 1.8 1.2 4.1 0.9 1.4 1.4 0.8 1.3 4.48 YDR158W
1.1 0.5 1.8 0.8 1.3 1.0 0.8 1.2 1.1 1.7 1.6 1.0 2.6 0.9 1.0 0.6 1.0
0.9 3.54 YDR204W 0.9 2.3 3.0 1.4 1.0 2.2 2.2 1.1 5.7 3.7 2.2 1.2
2.9 1.1 0.6 2.8 1.1 1.7 0.62 YDR313C 1.2 1.2 1.2 1.4 1.3 1.4 1.5
1.2 4.7 2.6 1.5 1.2 2.3 1.3 0.8 2.9 1.1 1.3 0.84 YDR368W 2.0 2.2
2.2 1.8 1.0 3.0 2.1 1.7 3.8 3.8 1.8 1.4 2.6 2.0 1.2 2.3 1.1 2.0
1.70 YER091C 3.6 3.9 30.7 1.3 0.9 2.3 2.1 0.9 5.8 1.4 3.2 2.0 5.4
1.2 10.2 2.7 1.2 1.0 1.23 YFR053C 1.7 1.4 3.0 2.2 0.9 3.2 2.1 2.8
0.6 1.1 1.5 1.7 3.0 0.6 0.6 3.0 1.4 2.2 4.17 YGL062W 0.6 1.3 1.1
0.6 0.9 1.0 1.3 0.8 1.6 2.5 0.7 1.6 4.5 1.2 2.7 1.5 1.1 0.9 0.77
YGL157W 0.7 0.9 1.8 0.9 1.5 5.4 3.3 1.4 0.6 1.8 1.4 1.5 4.8 1.2 5.1
1.7 1.8 2.3 1.69 YGL184C 4.6 15.9 57.4 1.3 1.1 1.0 1.2 1.9 37.9
66.8 1.7 2.6 7.4 1.4 0.4 1.5 1.0 0.9 0.16 YGR032W 1.0 1.4 1.0 1.3
0.7 1.9 0.8 0.6 0.5 0.7 1.5 1.5 3.9 1.1 5.4 1.5 3.2 2.8 1.18
YGR124W 0.5 0.6 1.7 0.7 1.2 1.1 0.7 1.0 2.2 1.3 1.1 1.1 2.3 0.5 1.5
0.3 0.7 0.6 3.56 YGR192C 1.4 1.0 3.8 1.0 1.1 1.7 1.7 1.1 0.9 1.3
2.3 2.2 3.4 1.0 1.9 1.1 1.1 1.3 7.49 YGR244C 1.0 1.2 1.6 1.6 0.8
2.6 3.9 1.8 1.4 1.1 1.8 1.9 2.6 1.2 2.0 2.6 1.9 3.1 1.12 YGR254W
1.2 1.3 3.8 1.3 1.2 1.9 1.5 1.4 0.8 1.2 1.3 1.7 3.1 0.6 2.4 1.4 1.3
1.2 7.01 YHR018C 1.0 1.0 1.5 1.4 1.7 1.1 0.8 1.0 1.4 4.4 1.4 1.4
3.3 1.0 4.4 1.0 1.9 1.2 1.21 YIL160C 0.8 2.4 2.3 3.5 1.0 1.6 1.1
1.2 3.2 3.8 2.4 1.0 2.3 1.5 5.6 8.8 2.4 3.0 0.27 YIR017C 3.5 8.6
2.5 1.9 0.8 1.9 1.5 1.2 5.2 3.4 4.2 1.2 3.4 1.9 2.3 3.0 1.5 1.3
0.36 YJL052W 1.5 0.9 4.0 1.8 0.7 2.4 2.1 1.5 1.6 2.0 4.3 2.4 5.6
1.3 2.3 2.3 1.2 1.9 6.19 YJR009C 1.1 1.7 5.6 1.0 1.2 1.6 1.6 1.1
1.1 1.3 1.1 1.5 2.7 1.0 2.1 1.5 1.1 1.3 5.86 YJR130C 1.1 0.6 0.8
0.9 1.4 2.0 1.3 1.3 5.2 3.8 1.7 1.0 2.9 1.1 0.9 1.5 1.1 1.3 0.62
YJR149W 1.0 1.8 1.4 2.3 0.8 1.0 1.7 1.0 1.4 1.0 0.7 1.0 3.5 1.4 1.4
2.4 1.1 1.2 0.34 YKL218C 2.1 1.0 2.2 1.8 1.2 3.6 1.6 1.7 3.4 2.7
1.7 1.2 5.1 1.4 0.8 3.1 2.5 2.6 0.60 YLR027C 1.0 1.5 2.3 0.8 0.9
2.0 1.4 0.7 1.6 2.7 1.6 1.3 2.5 1.0 1.4 0.9 1.3 1.3 1.39 YLR133W
0.9 1.6 1.4 0.7 1.0 2.2 1.3 0.7 6.1 2.3 0.6 1.5 3.3 1.1 1.9 1.0 1.1
1.3 0.36 YLR155C 1.4 1.1 2.4 1.8 1.7 1.6 2.0 1.0 3.0 1.8 2.0 1.1
3.3 1.1 1.2 2.2 1.4 2.2 1.63 YLR158C 1.4 1.2 2.1 1.7 1.7 1.5 2.0
1.1 2.7 s 2.4 1.1 3.2 1.2 1.1 2.1 1.4 2.0 1.57 YLR195C 0.8 0.9 1.0
0.8 1.0 0.8 1.1 1.0 0.6 0.7 0.8 1.3 2.3 0.7 0.9 0.8 0.9 1.0 1.55
YLR345W 1.4 1.4 1.4 1.2 1.2 1.6 1.2 1.4 4.5 4.0 2.5 1.6 3.5 1.5 1.0
1.2 1.2 1.4 2.65 YML004C 0.8 1.6 2.5 1.0 0.7 1.7 2.1 1.9 3.9 2.2
2.2 1.1 2.4 1.4 2.1 4.5 1.5 2.4 2.41 YML131W 11.2 4.3 7.7 1.9 0.7
2.0 3.0 6.1 11.1 17.7 14.4 1.1 2.4 2.7 2.2 1.6 2.5 3.0 1.15 YNL071W
0.9 0.9 1.7 1.5 0.6 1.3 1.4 0.9 1.1 1.2 1.6 1.3 2.5 0.8 1.1 1.1 1.0
1.2 1.61 YNL241C 1.3 2.5 4.3 1.0 0.8 0.9 3.2 0.9 3.4 7.4 3.0 2.0
4.9 1.1 7.0 2.8 1.0 1.0 0.68 YOR120W 1.8 5.4 2.8 3.2 1.4 3.4 2.7
2.0 3.3 3.0 3.0 1.2 3.6 2.4 1.5 3.9 1.3 2.6 1.06 YAL023C 0.4 1.5
1.0 0.7 1.0 0.6 0.8 0.6 0.3 0.4 1.7 1.2 2.3 0.4 2.5 0.4 1.0 0.7
1.49 YAL060W 1.1 1.8 3.2 2.7 1.2 4.2 3.3 0.9 0.6 2.5 2.4 0.8 2.2
0.9 0.9 3.2 1.1 1.8 2.39 YAL062W 0.8 1.5 1.4 1.1 1.0 1.2 1.1 0.8
1.4 0.7 1.2 1.0 2.1 0.8 1.1 1.3 1.0 0.8 0.86 YBR006W 1.3 1.6 2.6
1.5 1.3 3.1 3.3 1.0 4.5 2.7 1.9 1.1 2.2 1.1 1.1 3.0 1.2 1.8 0.62
YBR056W 1.4 1.7 1.4 2.3 1.4 2.3 5.5 1.4 3.0 3.3 1.8 1.4 3.0 1.0 0.7
2.8 2.4 3.4 1.13 YBR149W 1.1 2.0 2.7 1.7 1.4 2.8 3.1 1.5 1.7 1.9
1.9 1.4 2.2 1.2 0.7 2.7 2.1 3.4 2.72 YBR284W 0.9 1.5 2.8 4.8 1.3
1.9 1.0 0.9 6.5 3.2 1.4 1.2 2.8 1.6 0.8 0.8 1.1 1.0 0.25 YCL018W
1.2 2.7 2.4 1.4 0.8 2.3 2.3 1.3 2.1 4.3 3.7 1.6 3.2 1.0 0.6 2.3 1.3
1.0 0.99 YCL040W 0.9 7.1 10.1 2.0 0.5 3.5 2.9 0.7 0.9 3.0 8.2 2.3
5.6 0.7 3.4 3.1 1.4 1.7 1.98 YDL010W 1.7 0.8 0.6 0.7 1.2 1.1 1.9
1.1 2.2 1.3 1.3 0.9 2.0 2.2 1.4 1.4 1.5 2.4 0.93 YDL024C 1.6 1.5
1.2 2.2 1.0 1.7 0.9 1.7 4.2 3.4 1.2 1.7 2.6 1.9 2.1 2.8 0.9 1.1
0.40 YDL095W 0.5 1.3 1.0 0.8 0.8 1.0 0.8 0.7 1.2 0.7 1.0 1.1 2.2
0.5 2.0 0.5 0.7 0.9 1.57 YDL245C 1.0 2.4 1.6 2.2 1.3 1.1 1.2 1.2
0.4 2.8 1.5 1.0 2.0 1.2 1.8 1.5 1.0 1.1 0.28 YDL246C 1.2 1.5 1.3
1.1 1.1 1.4 2.1 2.4 4.4 3.6 2.6 1.2 2.9 1.7 2.6 1.7 1.8 1.8 0.43
YDR001C 0.8 2.2 2.6 1.0 1.1 2.2 1.5 0.9 2.2 3.0 0.7 1.1 2.8 1.0 4.4
1.9 1.1 1.6 0.75 YDR058C 1.2 2.2 0.8 2.7 0.7 1.0 1.4 1.9 2.4 1.7
1.7 1.2 2.5 1.8 1.2 1.9 1.1 1.6 0.56 YDR072C 1.3 1.3 1.7 1.2 0.9
1.5 0.9 0.7 0.6 0.7 0.7 0.9 1.9 0.6 0.4 0.7 1.9 1.9 2.81 YDR127W
0.8 0.9 1.5 0.7 1.2 0.8 0.9 0.7 0.6 1.3 1.3 0.8 1.7 1.0 1.3 0.6 0.9
0.7 0.78 YDR261C 1.2 1.2 1.9 0.7 1.3 1.4 0.8 0.9 1.7 1.0 1.2 1.0
1.9 0.9 2.3 0.6 0.9 0.8 0.68 YDR272W 1.0 4.0 0.8 1.8 0.7 2.3 1.7
2.1 2.5 1.9 2.1 1.2 2.4 1.4 1.1 2.1 1.4 2.3 1.51 YDR497C 0.7 0.5
0.6 1.3 0.7 0.6 0.5 0.6 0.4 0.8 0.7 0.9 2.7 0.6 10.1 1.6 1.8 1.45
YDR516C 1.2 1.5 7.8 2.1 1.3 1.8 3.9 1.3 1.8 5.2 2.8 1.1 2.5 0.7 0.4
1.7 1.1 1.2 1.66 YER053C 1.6 1.8 1.9 1.7 0.6 2.8 2.8 1.3 1.3 3.9
2.4 1.7 4.1 1.3 1.1 2.8 1.2 2.3 1.83 YER096W 1.1 2.3 2.0 2.0 1.3
1.2 0.9 1.0 7.5 3.5 1.1 0.9 2.3 3.1 1.4 2.0 1.0 1.2 0.22 YER178W
0.8 0.9 3.6 1.0 0.7 2.5 1.6 0.8 1.7 1.3 2.5 1.3 2.4 0.9 1.8 1.0 1.1
0.9 2.18 YFL030W 1.6 6.0 3.1 2.0 1.1 1.3 0.6 1.6 24.5 4.9 5.4 1.2
2.2 0.8 1.1 0.6 1.0 0.8 0.50 YFL031W 0.5 1.3 2.1 0.7 1.0 0.3 0.9
0.7 1.0 0.7 1.2 1.0 2.6 0.4 2.7 0.9 1.2 1.1 3.16 YFR047C 1.3 4.0
2.7 2.6 1.2 2.0 2.0 1.0 3.0 1.5 2.3 1.7 2.7 1.9 0.6 3.6 1.5 1.6
1.57 YGL248W 1.3 1.3 0.9 0.7 1.3 2.7 1.6 0.8 0.2 2.9 1.0 0.8 2.0
1.3 1.8 2.9 1.1 1.2 0.22 YGR037C 1.0 1.2 2.2 0.8 1.0 1.1 1.4 1.4
1.7 1.4 1.4 1.5 2.7 1.5 1.5 2.6 1.4 2.0 3.40 YGR055W 2.5 5.7 12.0
0.7 1.3 1.1 0.6 1.1 5.0 2.4 1.5 0.9 1.9 1.2 2.1 0.6 0.7 0.7 1.42
YGR194C 0.9 1.0 1.3 2.1 0.8 1.9 2.2 1.2 2.4 2.1 0.7 0.8 2.2 1.0 0.6
2.6 1.1 2.0 0.63 YGR256W 1.2 1.5 2.3 0.8 0.9 6.2 1.4 2.2 3.4 2.5
2.7 1.5 3.9 1.1 2.7 5.3 1.1 0.8 0.94 YHR111W 1.4 1.3 0.8 1.9 1.5
1.3 1.6 1.3 4.5 4.2 1.9 0.9 2.2 1.7 1.1 1.3 1.1 1.2 0.44 YHR174W
1.1 1.4 3.3 1.2 1.3 1.5 1.6 1.2 1.0 1.5 1.4 1.5 3.6 0.6 2.0 1.1 1.0
1.2 7.34 YHR176W 1.8 2.0 1.1 1.4 1.0 2.3 1.4 1.3 6.3 6.4 1.2 1.2
1.9 1.3 1.5 1.8 1.4 1.6 0.27 YIL045W 1.7 1.4 1.9 2.2 1.3 1.7 1.6
1.1 2.1 3.2 1.2 1.5 2.0 1.6 0.6 2.9 1.1 1.8 0.37 YIL107C 1.5 0.8
1.1 1.5 0.8 1.0 1.6 1.3 3.5 3.5 0.9 1.1 1.9 1.6 1.0 2.7 1.2 2.0
0.58 YIL155C 1.0 0.7 1.4 3.7 1.3 1.4 2.2 1.0 2.5 2.9 1.3 1.4 2.0
1.3 1.4 3.8 1.1 1.4 0.51 YIR034C 1.2 1.1 2.5 0.6 1.1 1.3 0.8 1.7
3.2 3.5 3.0 1.4 2.6 1.2 1.9 1.3 1.0 1.0 0.92 YIR036C 1.0 1.7 2.6
1.8 0.9 0.7 1.0 1.0 3.3 1.9 2.8 1.2 1.9 1.2 1.1 4.0 1.5 1.3 0.64
YJL031C 1.6 1.2 0.5 1.3 1.7 1.6 2.3 1.8 4.7 3.6 1.9 1.3 2.6 3.0 2.0
1.9 1.2 1.9 1.02 YJL068C 1.2 2.7 3.4 1.6 0.7 1.1 1.2 1.1 6.5 3.1
3.2 1.7 2.7 1.5 0.5 2.6 1.4 1.5 0.95 YJL099W 1.2 1.2 0.3 1.3 1.9
2.0 1.8 1.0 3.1 3.1 0.9 1.0 2.4 1.8 1.4 1.7 1.2 1.6 0.55 YJL172W
0.8 2.1 1.8 1.5 0.9 3.8 1.0 0.7 0.7 1.9 1.4 1.1 3.1 0.9 1.2 0.5 1.8
1.8 0.62 YJL219W 1.2 2.5 3.1 1.6 1.2 1.5 0.9 1.5 4.0 2.3 2.3 1.1
4.0 1.1 2.6 1.4 1.6 1.2 0.91 YJR137C 2.7 2.9 4.6 0.8 0.6 1.5 0.8
1.6 9.0 4.8 2.0 1.4 2.1 1.2 1.0 1.3 0.9 0.8 0.46 YKL035W 1.0 0.9
4.8 1.2 0.8 1.2 0.6 1.0 0.8 1.2 2.1 1.0 2.0 0.6 1.0 1.5 1.0 1.9
2.54
YKL091C 1.2 1.3 1.4 2.6 1.0 2.2 1.9 1.3 2.3 3.2 1.7 1.3 2.0 1.5 1.1
4.6 1.4 2.0 0.83 YKL104C 1.0 1.0 1.6 1.2 1.4 0.9 2.3 1.1 1.4 1.8
2.2 1.6 2.2 0.8 3.3 0.6 1.0 1.1 1.25 YKL152C 1.3 1.3 1.9 0.9 1.3
1.6 1.5 1.0 0.9 1.5 1.7 1.5 2.7 1.0 1.8 2.0 1.1 1.7 3.28 YKL213C
0.9 0.8 1.0 1.3 0.7 1.0 1.0 1.1 4.8 2.1 1.3 0.9 2.1 0.9 1.1 1.5 1.4
1.6 0.77 YKL215C 0.6 1.1 1.3 0.8 1.0 2.1 1.1 1.1 1.3 1.9 0.5 1.0
2.6 1.0 0.9 0.8 0.8 0.9 0.38 YLL058W 1.0 3.8 1.4 0.9 0.8 1.4 1.5
0.9 3.5 3.6 2.0 1.0 2.3 0.8 1.9 1.1 1.4 1.3 0.39 YLR299W 1.2 1.9
1.5 1.3 0.6 0.9 0.8 1.0 4.9 2.3 1.7 1.0 2.9 1.3 1.5 0.9 1.3 1.4
0.57 YLR348C 1.1 4.5 1.2 1.2 0.9 1.9 0.9 0.9 2.1 1.3 1.3 0.9 1.9
1.0 2.4 1.1 1.1 1.0 0.64 YML054C 1.5 1.8 1.3 3.4 1.3 1.8 1.2 1.5
4.1 1.8 1.4 1.8 2.8 2.1 1.1 7.8 1.1 1.6 0.25 YML070W 0.9 1.7 2.5
1.9 1.4 2.2 3.1 1.3 4.5 3.9 1.5 1.3 3.3 1.3 0.9 2.6 1.2 1.3 1.03
YML100W 0.8 2.7 10.6 1.4 0.9 2.8 2.2 0.7 1.7 1.4 3.2 1.2 3.8 1.2
1.8 2.2 1.0 1.5 0.88 YMR008C 0.7 0.9 1.4 1.0 1.1 1.7 0.9 0.5 0.3
0.6 1.3 1.1 3.7 0.7 2.0 1.2 3.0 1.9 1.59 YMR020W 1.3 1.0 0.9 1.7
1.4 1.6 2.7 1.2 2.3 2.9 1.5 1.1 3.0 1.1 1.8 2.8 2.3 2.2 0.81
YMR105C 1.9 3.0 5.0 4.2 0.9 2.8 2.8 1.1 0.6 2.9 3.0 1.7 3.3 1.0 0.9
2.0 1.6 2.6 1.21 YMR271C 1.6 1.6 1.3 2.0 1.1 4.2 3.4 1.8 8.0 4.4
1.7 1.3 3.6 1.8 0.6 5.7 1.3 2.2 0.70 YNL012W 1.3 1.3 1.8 0.8 1.3
1.7 2.0 1.8 3.3 3.2 1.6 1.3 2.9 1.0 1.6 1.2 1.3 1.5 0.24 YNL045W
0.8 1.3 2.0 1.3 1.1 2.2 1.8 0.7 1.3 1.1 2.1 0.9 2.6 0.8 0.8 2.4 1.1
1.1 0.80 YNL104C 1.1 1.3 3.0 0.9 0.8 0.8 0.6 0.9 1.1 2.0 2.1 1.1
2.1 0.9 2.5 1.5 0.9 0.9 1.69 YNL231C 1.5 0.8 0.8 0.5 2.1 1.8 2.5
1.5 2.2 1.3 1.3 1.8 2.9 0.9 0.9 0.7 3.1 4.0 2.13 YNR019W 1.0 1.3
1.6 1.2 0.8 1.3 0.8 0.7 1.8 1.9 0.7 1.0 2.1 1.0 1.6 0.8 2.4 2.0
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0.9 1.3 2.2 0.9 1.1 0.72 YNR059W 1.1 0.9 0.2 1.4 1.4 0.8 1.6 1.3
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1.6 0.7 1.5 1.4 0.9 0.8 2.4 1.8 1.1 2.6 1.2 1.4 2.5 1.6 2.4 0.59
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5.4 1.1 1.7 0.37 YOR099W 0.8 1.3 2.1 1.3 1.5 0.9 1.0 0.9 0.6 0.7
1.2 1.1 1.6 0.7 1.5 1.1 1.2 2.3 3.94 YOR130C 0.8 1.7 1.4 1.0 1.8
1.6 1.3 0.8 2.0 1.7 0.6 0.9 2.1 1.3 1.0 0.8 1.5 1.1 0.51 YOR336W
0.7 1.4 0.7 1.0 1.3 1.7 1.2 0.8 1.7 1.5 1.4 1.0 2.1 1.1 0.6 0.9 1.0
1.0 0.44 YOR347C 0.9 0.9 2.1 2.2 0.7 0.9 0.9 0.8 0.5 0.9 1.4 1.2
1.8 0.9 2.0 1.4 1.7 1.3 1.31 YPL017C 1.0 2.5 0.8 1.0 1.3 1.5 1.4
1.3 3.0 6.7 0.4 1.0 1.9 1.6 1.0 1.3 1.3 0.8 0.19 YPR026W 0.9 1.2
5.0 1.3 0.8 1.3 1.0 0.9 3.1 1.6 1.2 2.3 1.5 3.1 2.5 0.9 1.3 0.26
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3.1 1.0 0.9 0.8 0.96 YBR029C 0.7 0.2 1.8 1.0 1.4 0.8 0.4 0.7 2.0
1.1 0.7 1.3 1.7 0.9 3.5 0.9 0.6 0.8 1.56 YBR222C 0.6 1.2 1.3 0.8
0.7 1.3 1.0 0.6 0.7 1.0 1.3 0.9 1.6 0.5 4.3 2.1 0.8 0.9 0.52
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0.9 1.1 0.8 0.68 YCL064C 0.6 0.6 0.8 0.8 1.4 3.3 13.4 2.4 1.7 5.2
1.8 0.7 1.6 0.8 21.4 1.0 0.3 0.3 1.42 YCR098C 1.6 3.0 1.7 2.0 1.4
1.6 1.2 1.0 1.4 2.4 1.3 1.3 1.4 1.1 11.0 0.8 1.7 1.6 0.22 YDR502C
1.2 2.8 2.4 1.2 1.5 1.5 0.9 0.9 1.6 0.9 1.3 1.3 1.2 0.8 8.2 1.0 0.9
0.9 2.75 YER026C 0.8 0.6 3.3 1.0 1.2 2.5 1.6 0.8 0.9 1.5 0.9 1.7
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0.4 0.2 0.9 0.6 0.6 0.6 0.8 2.8 0.4 0.8 1.3 1.40 YMR189W 0.7 0.8
1.9 2.8 0.4 1.9 0.8 0.4 0.7 0.9 8.2 0.6 0.9 1.6 5.6 0.9 1.0 0.8
0.88 YNL106C 1.0 1.4 0.8 1.5 0.8 1.0 0.9 0.8 0.7 1.4 0.9 0.8 0.9
1.1 3.3 1.2 1.1 0.9 0.37 YNL169C 0.7 1.4 1.4 1.2 0.7 1.4 0.7 0.8
1.1 1.1 0.8 1.0 1.7 0.9 3.4 0.8 1.1 1.3 1.05 YNL322C 0.8 0.9 1.9
0.8 1.4 1.1 0.9 0.7 0.7 0.8 0.6 0.7 0.8 1.2 3.7 0.9 0.9 1.0 0.75
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0.9 1.0 1.0 7.02 YBR023C 0.5 0.8 1.3 1.1 0.8 0.5 0.7 0.5 0.3 0.4
0.9 0.8 0.5 0.8 2.8 0.7 0.7 0.9 0.93 YCR048W 0.5 1.1 1.0 0.6 0.9
0.2 0.9 0.8 0.8 0.5 1.2 0.9 1.3 0.9 3.1 1.1 1.2 0.8 0.29 YDR380W
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0.8 1.04 YER069W 1.3 0.8 3.3 1.4 1.5 1.3 1.0 1.5 0.8 10.4 1.5 0.8
1.4 1.3 2.4 1.1 1.1 0.9 0.25 YGL022W 0.5 0.8 1.4 0.3 1.0 0.9 0.7
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1.4 0.8 1.1 1.6 0.7 1.6 0.7 1.0 0.6 2.8 0.9 0.9 0.34 YGL209W 1.2
1.6 1.1 2.6 0.7 1.0 1.0 1.1 0.6 0.4 0.8 1.3 1.9 1.6 3.2 2.8 1.1 1.5
0.63 YGR282C 1.3 0.7 4.6 1.9 1.0 2.2 1.1 1.0 0.8 0.8 1.5 1.3 1.2
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2.4 1.0 1.2 1.1 1.7 0.9 4.3 1.2 1.2 1.0 0.39 YJL088W 0.9 0.8 2.2
0.5 0.9 2.8 1.3 3.2 4.1 0.9 0.7 1.0 2.0 5.7 0.7 1.4 0.9 0.27
YJR148W 0.7 1.4 2.0 3.5 0.6 2.0 2.1 0.6 0.7 3.0 0.6 0.8 1.1 1.3 3.2
1.3 1.3 1.7 1.50 YLR180W 1.3 1.4 2.4 1.0 0.8 1.2 0.6 0.9 0.8 0.9
1.7 0.6 0.6 0.6 2.5 0.5 0.8 0.7 3.23 YLR273C 1.4 1.0 1.3 2.4 1.2
1.2 1.3 2.8 2.4 1.4 0.9 1.7 1.3 2.6 1.5 1.0 1.0 0.20 YLR300W 0.9
0.8 0.8 1.0 0.8 1.1 0.5 0.8 0.0 0.5 1.0 0.5 0.2 0.6 2.7 0.3 0.7 0.5
5.14 YLR307W 0.9 0.4 0.7 3.3 1.4 1.2 1.5 1.2 0.6 0.7 0.8 0.7 1.0
1.9 3.9 0.9 1.1 1.0 0.16 YMR296C 0.6 0.7 1.2 2.6 0.4 0.4 0.6 0.5
0.4 0.6 0.8 0.8 0.9 0.7 6.7 0.5 0.8 0.7 0.52 YOL058W 0.8 0.5 1.7
0.9 1.2 0.8 0.4 1.6 0.1 15.7 2.3 1.3 1.2 1.5 2.7 0.9 1.2 0.8 0.82
YBR183W 1.8 1.5 2.0 2.9 0.9 2.5 1.7 1.0 0.4 2.0 1.9 1.2 1.4 1.3 1.1
2.1 1.4 2.4 1.47 YDR019C 1.4 0.5 1.7 4.0 0.9 4.8 1.4 0.7 0.4 0.7
1.8 0.7 1.0 1.6 1.8 1.8 1.2 1.6 2.48 YIL167W 3.3 1.6 2.0 1.0 1.0
7.7 1.2 1.9 6.9 12.7 1.9 0.7 1.2 1.4 0.6 2.3 0.7 0.8 2.11 YKR039W
1.4 3.5 1.3 1.7 1.0 2.8 1.0 1.0 1.9 2.0 1.9 1.5 1.3 1.2 1.7 1.9 0.9
1.1 0.40 YNL037C 1.4 1.8 1.7 1.1 1.7 2.8 2.8 1.0 0.6 3.2 1.4 1.3
1.9 1.3 0.9 1.4 0.9 1.3 2.05 YNR002C 1.3 1.6 1.0 2.0 1.2 2.3 1.2
1.0 3.9 1.6 1.6 1.2 2.1 1.2 1.0 2.4 1.5 2.1 0.29 YOL143C 1.0 1.4
1.2 1.2 0.9 3.5 1.3 1.2 0.8 1.0 2.0 1.2 1.2 0.7 1.0 2.2 1.8 1.4
2.30 YOR136W 1.0 0.9 3.5 1.0 1.5 3.9 3.2 1.1 0.3 3.4 1.4 1.2 1.5
0.9 1.2 1.3 0.8 1.3 3.20 YAL044C 1.5 1.1 1.0 3.0 0.8 2.2 1.0 0.8
0.4 0.6 1.4 0.6 1.1 1.4 0.7 1.0 1.4 1.8 4.07 YAL054C 1.2 1.1 1.4
1.6 1.1 2.2 1.1 1.1 8.9 4.1 1.3 1.0 1.8 1.3 0.9 2.5 1.5 1.4 0.24
YAR071W 1.6 0.8 1.0 0.7 1.6 2.0 0.3 1.4 0.3 0.3 1.1 2.0 0.3 1.1 1.1
0.3 0.7 1.6 3.21 YBL001C 1.1 1.5 1.0 1.6 1.0 2.4 1.3 1.0 1.5 0.9
2.3 0.7 1.0 1.5 1.0 1.7 1.6 1.8 2.38 YBR014C 1.1 1.2 0.8 0.9 1.4
2.0 1.4 1.2 1.3 0.8 1.8 0.6 0.9 1.2 1.2 1.5 1.0 1.6 1.29 YBR035C
1.1 1.0 1.7 1.1 1.3 2.3 1.5 1.5 2.2 1.5 2.0 1.2 1.8 1.3 0.7 2.1 1.5
1.9 1.89 YBR068C 1.1 1.0 1.9 2.5 1.4 1.9 1.0 0.8 2.5 0.8 0.8 2.2
1.8 1.6 5.5 1.1 1.3 1.99 YBR111C 1.0 0.9 1.0 1.7 1.3 3.0 2.2 1.7
1.9 1.9 1.5 1.2 1.6 1.6 0.7 3.5 1.4 2.4 3.20 YCR037C 0.7 1.0 0.8
0.8 1.3 1.8 1.0 0.7 0.6 0.6 0.8 0.7 1.3 0.8 1.0 1.1 1.4 0.9 0.74
YDL022W 0.9 2.6 6.9 1.5 0.7 2.1 1.5 0.8 1.2 1.8 2.8 1.2 1.5 0.8 0.9
1.1 1.0 1.4 1.79 YDR009W 1.4 0.8 1.5 1.0 1.2 2.4 1.4 1.2 1.3 2.0
0.1 1.0 1.2 1.5 3.2 1.0 1.2 1.0 0.21 YDR410C 0.8 2.0 1.3 0.9 1.1
2.5 1.4 0.9 1.2 1.5 1.6 0.9 1.2 1.3 1.2 0.8 1.0 1.0 1.33 YDR487C
2.2 0.9 1.3 1.1 1.3 2.3 1.3 1.8 2.7 2.3 2.1 1.3 1.5 2.5 1.0 1.5 1.5
1.9 2.61 YEL011W 2.0 1.6 1.7 6.3 1.1 2.8 2.7 0.9 2.5 1.6 3.7 1.5
1.5 1.5 0.4 2.4 1.4 2.5 0.89 YFR015C 1.2 0.8 3.2 2.1 1.2 3.0 7.3
0.7 0.3 1.8 3.9 0.4 2.5 3.1 0.4 2.4 1.3 1.2 0.66 YGL001C 1.0 1.0
1.4 1.1 1.5 2.8 1.4 1.1 0.8 0.8 1.6 0.9 1.0 1.1 0.9 2.2 1.9 2.1
2.53 YGL104C 0.8 2.0 2.1 1.8 1.0 2.1 1.2 0.8 4.6 2.1 1.8 1.1 2.0
1.0 0.9 1.7 1.3 1.3 0.58 YGL154C 1.3 1.4 1.5 0.9 1.0 1.7 0.7 1.2
2.0 1.4 0.9 0.9 2.0 1.1 0.8 0.7 1.0 1.1 0.57 YGL253W 0.8 1.0 3.2
0.7 1.3 2.4 1.7 1.1 0.3 1.4 1.0 1.2 1.5 0.5 0.8 0.4 0.7 0.8 4.63
YGR060W 0.7 0.6 0.9 0.7 1.9 2.5 0.5 1.0 0.5 0.4 0.8 1.0 0.6 0.8 1.4
2.1 1.3 1.6 4.19 YHR037W 0.7 0.9 1.3 1.6 0.9 1.8 1.2 1.0 0.9 2.2
1.7 1.1 1.1 1.1 1.1 2.0 1.0 1.4 1.15 YHR092C 2.3 1.0 7.5 2.5 1.4
1.7 0.5 1.5 0.2 0.9 1.5 1.0 0.5 1.6 0.2 1.2 0.9 1.3 6.09 YHR190W
0.8 3.9 1.2 1.2 1.8 1.7 1.9 1.2 2.4 1.9 1.3 1.1 1.7 1.3 1.3 1.8 1.3
1.8 2.15 YIL033C 0.8 1.3 3.3 1.3 0.7 2.0 1.1 0.7 2.4 1.3 1.8 1.1
2.5 0.7 1.0 2.0 1.0 1.2 1.18 YIR035C 1.4 1.8 0.9 1.6 0.7 2.1 1.3
1.3 0.7 1.2 1.3 0.9 1.1 1.1 1.4 1.0 1.1 0.9 1.51 YJL132W 1.0 0.7
0.8 1.6 1.3 2.0 1.7 1.0 1.6 1.4 1.4 1.0 1.3 1.4 1.1 2.1 1.3 1.5
0.37 YJL196C 0.9 0.9 2.5 1.3 1.1 2.0 0.7 0.7 1.1 0.9 2.3 1.1 0.6
0.8 0.6 1.7 0.9 1.9 2.85 YJR142W 1.2 0.6 1.1 1.1 1.3 2.4 1.7 1.0
0.6 0.8 0.9 0.8 1.6 1.3 0.6 2.0 1.2 1.4 0.94 YKL067W 1.1 1.9 2.1
1.4 1.9 2.2 2.6 1.2 0.9 1.6 1.8 0.9 1.7 1.2 1.1 2.4 1.4 3.2 3.29
YLR142W 4.4 2.7 1.1 6.1 1.3 3.1 1.2 2.1 3.1 4.4 3.8 0.8 1.2 2.1 1.6
3.4 1.9 3.2 0.28 YML110C 1.1 0.8 1.9 1.6 0.8 2.6 2.0 1.4 2.7 2.2
1.7 1.1 1.8 1.4 1.3 2.3 1.1 1.6 2.01 YMR272C 0.7 1.0 1.6 0.7 1.1
2.6 1.0 0.8 0.4 0.6 0.8 1.2 1.2 0.8 1.1 1.5 1.3 1.4 1.66 YNL130C
0.6 0.7 2.4 0.7 0.8 2.4 1.3 0.8 1.7 2.4 1.5 0.9 1.9 1.0 2.5 0.7 0.7
1.2 1.18 YPR006C 1.9 1.5 0.5 1.9 2.0 2.4 2.8 1.5 1.5 3.9 2.4 1.1
1.8 1.2 0.7 1.6 1.8 2.1 0.46 YBR050C 2.4 1.9 1.9 3.1 1.0 4.1 2.6
1.7 5.8 3.2 1.1 1.0 1.3 1.3 0.5 1.7 1.5 1.8 0.41 YBR145W 1.5 0.7
2.8 0.9 1.1 11.5 58.8 1.0 0.1 1.1 1.1 1.0 2.0 2.2 1.2 3.6 1.7 2.0
2.17 YBR299W 1.8 0.9 1.1 3.5 1.6 0.8 3.6 2.2 1.1 5.3 2.4 1.2 0.7
1.4 0.6 3.9 1.0 1.1 0.32 YEL020C 1.0 1.5 0.8 2.9 1.5 1.3 2.4 1.2
1.4 1.1 1.3 0.8 1.2 1.0 1.4 2.1 1.2 1.3 0.31 YGL039W 0.8 1.4 2.1
1.3 1.3 1.7 4.2 1.3 0.7 2.8 1.1 1.3 1.5 0.9 1.5 1.5 0.6 1.0 1.09
YGL134W 0.9 1.3 0.5 0.8 1.4 1.2 2.3 1.4 1.1 1.4 1.1 0.9 0.7 1.1 0.5
1.7 0.9 1.3 0.53 YJR159W 1.4 2.3 1.3 1.7 0.9 1.4 2.3 2.7 5.2 2.8
2.2 1.5 2.1 2.0 2.3 5.2 1.7 2.3 0.30 YOL157C 1.0 1.1 1.3 2.5 1.4
0.9 2.7 1.4 2.3 4.8 1.2 1.2 1.4 1.2 1.1 3.5 1.4 1.3 0.41 YOR344C
1.1 1.1 0.4 0.7 1.9 2.0 2.4 1.4 0.3 0.9 0.6 1.3 1.8 0.6 0.7 0.6 1.3
1.3 2.11 YPL265W 0.7 0.4 2.3 1.1 1.0 2.3 8.9 2.3 0.2 1.2 1.8 0.9
1.1 1.1 1.2 2.0 0.5 0.4 1.42 YBR126C 0.8 1.9 5.6 1.2 0.7 2.9 2.3
0.6 1.7 1.1 1.3 2.1 0.7 1.0 1.7 1.5 1.3 1.96 YCR005C 1.1 1.9 2.0
1.2 0.9 1.6 4.4 1.2 1.5 1.5 2.1 0.5 0.7 0.8 0.7 0.7 1.6 1.7 2.38
YDR452W 1.1 1.1 1.3 0.8 1.2 2.0 1.9 1.0 1.4 1.3 1.5 0.9 1.4 1.2 1.3
1.3 1.9 2.2 1.54 YGR019W 1.2 0.8 1.4 1.7 0.8 2.4 2.4 1.2 2.9 1.1
1.2 2.1 1.3 2.2 2.4 1.3 2.0 0.79 YGR255C 0.9 1.4 1.4 1.5 1.3 3.2
1.8 1.0 2.5 1.8 2.0 1.3 2.5 0.9 1.0 1.1 1.1 1.1 0.81 YIL098C 1.4
1.6 0.5 2.0 1.7 1.7 2.2 1.6 1.9 1.9 1.4 0.8 1.3 1.9 0.7 2.0 1.2 1.6
0.75 YIL172C 1.1 1.1 1.6 1.7 1.3 2.5 1.6 2.8 7.1 1.0 1.4 2.0 1.3
1.4 2.8 1.1 1.2 0.42 YLR100W 0.8 1.4 1.3 1.9 1.8 1.8 2.3 1.0 0.9
1.0 0.9 1.1 1.6 1.1 0.6 1.9 1.5 2.1 1.88 YOR221C 0.8 1.0 0.9 1.1
1.7 0.8 2.1 0.9 1.4 1.7 1.1 0.8 1.0 1.1 1.0 1.4 0.9 1.2 0.39
YPL123C 1.2 0.8 1.8 3.0 0.8 1.9 2.7 1.2 4.2 2.3 1.9 1.0 2.2 1.6 1.4
2.6 1.6 3.2 0.71 YBR093C 2.9 1.2 1.7 1.3 1.1 0.6 0.3 1.7 0.1 0.5
3.1 2.0 0.2 1.3 2.7 0.4 0.8 1.9 3.33 YBR196C 0.8 0.6 3.9 1.4 0.8
0.8 1.4 1.1 0.3 0.9 2.3 1.0 1.4 0.5 1.9 1.1 0.8 1.0 6.60 YER023W
0.8 0.6 1.2 1.2 0.8 1.3 0.7 0.9 1.1 0.6 2.1 0.8 1.2 0.7 1.2 1.6 1.5
1.4 1.77
YFL055W 2.0 6.7 1.3 2.5 1.5 1.1 1.4 1.3 23.9 6.5 2.7 0.9 1.3 1.5
0.7 1.4 1.4 1.0 0.23 YIL124W 0.9 0.8 2.8 1.6 0.9 1.2 1.3 0.9 1.0
0.7 2.8 1.1 0.9 1.1 0.6 3.1 1.2 2.1 2.39 YMR318C 1.4 2.4 2.2 0.7
1.2 2.1 0.8 3.6 2.3 4.8 3.6 0.8 1.8 1.7 1.5 1.1 1.1 1.1 3.17
YBR067C 1.6 2.5 2.8 0.9 1.1 1.1 1.1 1.1 1.7 1.0 3.1 1.0 0.9 0.7 3.3
2.5 0.5 0.4 1.76 YBR115C 0.6 0.7 1.4 0.4 0.7 0.9 1.1 1.3 0.8 1.6
1.8 0.9 2.3 0.7 1.1 0.5 0.6 0.6 0.64 YDL131W 1.1 0.9 1.8 1.0 1.0
0.9 0.7 2.2 0.8 2.7 2.2 1.2 1.0 0.9 1.1 0.9 0.7 0.6 1.81 YDL168W
2.3 2.0 2.1 0.9 1.2 1.4 1.1 1.7 8.2 4.7 1.9 0.6 1.3 1.6 1.2 1.1 0.9
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2.4 0.9 2.5 1.6 1.0 1.8 0.44 YDR253C 5.7 6.4 1.4 3.2 0.9 0.8 1.0
1.7 14.8 6.3 2.3 1.0 2.2 3.6 1.2 1.6 1.0 1.0 0.38 YDR513W 2.2 2.5
2.3 2.6 0.9 2.1 1.6 1.6 4.6 3.1 2.0 0.9 1.8 2.0 1.3 3.8 1.3 3.2
3.10 YER061C 0.9 0.9 1.2 2.5 0.8 0.4 0.9 0.7 0.3 0.7 2.2 0.7 0.9
1.0 0.8 1.8 1.2 1.2 0.84 YFL052W 1.3 0.8 0.7 2.3 1.5 2.1 1.4 1.3
0.6 1.2 2.3 0.8 1.0 1.6 0.4 1.0 1.1 0.9 0.32 YFL058W 1.2 1.7 1.1
1.4 1.1 2.0 0.9 1.7 3.2 2.4 2.4 1.2 1.2 1.0 1.7 0.7 1.1 0.9 0.40
YFR030W 3.1 5.5 8.5 0.5 0.8 1.8 1.1 1.7 24.1 9.0 2.4 2.4 4.1 1.3
1.7 1.6 1.3 0.9 0.30 YGL202W 0.8 0.7 2.2 0.7 0.7 0.7 0.6 1.0 1.3
1.7 2.4 0.9 1.1 0.8 2.2 0.6 1.3 0.9 1.70 YGR070W 1.1 1.0 2.0 1.5
1.4 1.4 1.8 1.1 1.5 1.8 0.6 1.4 1.0 2.6 2.3 1.2 1.3 0.40 YHL036W
2.2 4.8 3.4 2.0 1.3 1.3 1.0 1.2 9.0 4.4 2.3 1.2 1.5 1.2 0.9 1.1 1.0
1.0 0.60 YHR104W 1.0 4.1 15.7 1.9 1.1 1.2 1.5 1.1 4.8 2.3 2.6 1.0
1.2 1.5 1.6 1.3 1.9 1.9 1.57 YJL045W 1.8 2.2 1.6 5.3 0.7 0.6 0.7
0.9 9.7 1.6 2.3 1.1 1.6 1.2 3.4 2.4 0.9 0.9 0.42 YJL060W 1.8 2.6
9.6 1.0 1.4 1.3 1.3 0.8 5.3 2.8 1.6 1.5 2.1 1.7 1.4 1.5 1.2 1.1
0.95 YJL155C 2.1 5.0 0.8 2.4 0.8 0.8 2.0 1.5 3.8 2.8 2.4 1.0 6.6
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1.2 1.1 0.7 1.3 0.9 1.4 1.0 3.8 2.4 1.3 0.7 2.0 0.9 1.7 1.0 0.9 1.1
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0.9 0.9 1.2 1.0 1.3 1.2 1.0 1.3 0.91 YGL254W 1.2 1.1 0.8 0.6 1.1
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1.1 0.97 YHR106W 0.9 1.7 1.7 1.5 1.7 1.3 1.2 1.0 2.8 2.5 1.4 0.7
1.0 1.2 0.9 2.4 1.3 1.1 1.73 YIL046W 1.5 2.7 1.6 0.7 1.4 0.9 1.0
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1.3 1.6 1.4 1.0 1.3 1.1 2.8 2.2 1.3 1.1 1.0 1.0 1.5 1.2 0.9 0.9
0.41 YJR139C 1.4 2.6 2.9 1.1 1.2 1.8 1.3 1.1 4.1 1.9 1.5 1.0 1.5
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YLR070C 1.0 1.3 1.4 1.1 0.7 1.1 1.3 1.0 3.5 1.6 0.4 0.7 2.0 1.3 0.5
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1.9 1.9 1.5 5.1 1.8 1.9 1.2 1.8 1.1 1.1 2.1 1.6 2.1 1.70 YLR160C
1.2 1.4 3.9 1.1 1.3 1.8 1.9 2.0 4.8 1.8 1.6 1.2 2.0 1.2 1.0 2.0 1.6
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1.0 1.5 0.7 11.0 1.5 1.2 0.31 YML042W 0.9 1.4 1.5 2.2 1.0 0.9 0.8
1.6 3.8 2.4 2.5 1.0 1.2 1.4 1.7 4.8 1.0 0.9 0.29 YOL049W 0.9 1.1
1.3 0.9 1.4 0.6 1.1 1.0 3.0 1.9 1.8 0.8 0.9 0.9 0.7 1.3 1.0 1.3
1.61 YOL064C 1.4 2.1 1.1 0.6 0.9 1.4 1.2 1.0 8.7 2.7 1.0 0.9 2.0
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3.8 1.1 1.2 0.9 1.3 0.9 1.2 1.3 1.1 1.1 0.46 YPL031C 0.9 2.0 1.4
0.8 1.5 1.8 1.6 1.0 5.7 1.4 1.4 0.8 1.6 0.9 0.7 2.0 1.4 1.2 0.49
YPL113C 1.4 1.7 0.4 2.4 1.3 1.0 1.9 1.4 5.5 2.0 1.5 1.1 1.7 1.6 0.9
2.5 1.2 1.7 0.28 YPL274W 0.8 4.2 3.8 0.8 0.6 1.1 0.7 0.9 4.1 3.6
2.0 0.5 0.6 0.9 1.5 1.1 0.7 0.6 0.41 YPR048W 1.3 2.0 0.9 1.1 0.9
0.6 0.9 1.5 4.0 2.1 1.0 0.8 0.6 1.2 0.6 0.8 0.7 0.8 0.75 YBR001C
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1.1 1.8 1.9 2.2 1.0 1.7 1.4 1.2 2.3 1.1 1.5 0.84 YBR241C 0.9 9.3
2.6 0.9 0.9 1.5 1.4 0.7 29.8 2.2 1.4 1.4 1.4 0.9 1.6 0.7 1.0 1.2
1.25 YCR105W 2.2 1.2 1.2 3.0 0.9 1.0 1.0 1.4 2.0 3.9 2.3 0.9 1.9
1.9 3.1 1.3 1.3 1.1 0.36 YDR287W 1.1 8.4 1.9 1.2 1.2 1.6 1.2 1.2
2.5 1.8 1.5 1.1 1.5 1.2 1.6 2.7 1.5 1.3 0.52 YDR294C 0.7 1.1 1.9
1.2 0.9 0.7 1.0 1.0 2.0 2.9 1.2 1.1 1.6 1.0 2.0 1.7 0.9 1.1 1.02
YER052C 1.1 1.0 3.6 1.1 0.6 0.6 0.5 1.0 2.7 2.4 1.1 0.9 2.1 0.7 1.2
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1.3 0.9 1.5 1.1 1.3 1.0 0.8 0.5 0.40 YGL040C 0.7 1.2 1.4 0.9 1.3
2.0 1.1 1.0 2.1 1.9 0.9 0.6 1.6 1.3 0.7 1.5 0.7 1.0 1.77 YGL125W
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0.27 YGR007W 1.3 1.7 0.7 1.6 0.6 0.8 1.2 1.1 2.2 2.3 0.9 0.8 1.4
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YIL170W 1.1 1.0 2.5 2.2 0.9 8.8 0.5 1.2 5.7 3.2 1.7 0.7 1.9 1.1 2.3
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1.2 0.8 1.0 1.2 0.8 0.7 0.9 0.8 0.44 YIR032C 1.1 1.9 1.3 2.6 1.0
0.6 1.0 1.2 2.6 2.3 1.4 1.0 1.4 1.6 0.6 1.6 0.9 1.1 0.40 YJL128C
0.8 1.4 0.4 0.8 1.2 1.3 1.8 0.9 2.0 1.7 0.6 1.0 1.7 0.8 1.2 0.9 1.0
1.0 0.42 YJR090C 0.8 1.0 0.6 0.8 1.2 1.2 0.8 0.8 1.9 1.2 0.4 0.8
2.2 1.0 1.6 0.8 1.1 1.0 0.60 YJR103W 1.1 3.8 1.2 1.6 0.7 0.6 0.6
0.8 1.8 3.0 1.1 0.6 0.7 0.7 3.2 2.3 0.9 1.0 0.74 YJR153W 1.1 1.7
1.1 0.8 0.9 0.4 1.3 0.9 2.4 1.6 2.0 0.7 1.3 1.7 2.9 1.6 0.8 1.0
0.18 YKL192C 1.1 1.0 3.7 1.1 1.1 1.8 1.1 0.9 3.5 1.6 1.1 1.2 1.7
1.5 1.2 2.1 1.0 0.8 1.57 YLR025W 1.2 5.1 0.7 1.1 1.9 1.5 1.7 1.5
2.4 1.5 1.1 0.9 1.0 1.7 1.5 2.2 1.2 1.3 1.15 YML051W 1.0 1.4 1.8
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YML099C 0.6 1.0 1.1 1.3 1.0 0.5 1.0 0.7 2.2 1.7 1.6 1.1 1.3 0.9 1.0
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2.0 1.1 1.1 2.1 1.4 1.0 1.1 1.7 0.8 1.0 1.4 0.9 1.3 0.63 YNL264C
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1.5 2.14 YMR083W 1.4 1.7 2.6 1.1 1.5 1.8 1.7 1.1 0.4 1.1 1.6 0.7
0.9 0.8 1.3 1.3 0.9 1.1 2.52 YOR178C 1.4 1.3 4.8 2.3 1.0 2.7 0.9
0.9 0.2 1.7 4.1 1.7 1.0 1.0 1.1 1.7 1.0 1.5 0.56 YPL028W 0.7 0.9
2.6 0.9 1.0 1.2 1.3 0.9 1.2 0.8 1.2 1.4 0.9 0.8 0.6 2.2 1.4 1.8
4.35 YPR113W 1.1 0.8 3.7 1.3 2.0 1.1 1.2 0.9 0.4 0.8 2.0 0.7 0.7
1.3 1.0 2.3 1.2 1.9 2.85 YPR183W 0.9 1.5 3.5 0.8 0.9 1.2 1.2 1.0
0.9 0.6 2.5 1.2 1.6 0.7 0.9 0.8 1.2 1.0 1.17 YBR011C 1.3 1.8 2.5
1.1 0.9 2.0 1.1 1.3 2.2 1.0 1.7 1.1 1.5 0.9 2.1 1.7 0.8 1.1 3.68
YCR034W 0.8 0.4 2.5 0.9 0.9 0.3 0.3 0.9 0.1 0.2 0.8 0.5 0.2 0.6 0.9
0.3 0.9 0.7 3.77 YDR050C 1.6 1.3 2.3 1.8 0.9 1.7 1.5 1.3 0.4 1.3
2.0 1.4 2.0 1.2 1.9 1.3 1.1 2.3 6.26 YDR178W 2.0 2.0 3.4 2.2 0.9
2.1 0.6 0.9 0.9 0.8 2.0 1.3 1.5 1.5 0.7 3.0 1.2 2.3 2.27 YDR284C
0.8 1.5 3.0 2.9 0.8 1.8 1.4 0.9 0.9 1.0 1.3 0.9 1.2 1.3 0.9 1.7 1.5
1.5 1.44 YDR345C 0.8 0.9 5.6 2.6 1.3 1.2 1.1 1.2 0.2 1.1 1.5 1.4
1.2 0.8 0.8 1.0 1.3 1.8 5.65 YDR400W 1.0 2.0 2.2 0.7 1.0 1.1 0.6
1.4 1.1 1.4 1.3 0.4 0.7 0.9 0.8 1.1 1.1 0.8 0.56 YEL063C 0.7 0.8
2.4 1.3 1.2 1.3 0.7 0.6 0.8 1.7 0.8 1.1 1.1 0.8 1.3 1.0 0.7 0.7
1.12 YER081W 1.6 1.9 2.7 1.4 1.1 1.1 0.5 0.6 1.8 1.1 1.1 1.0 0.6
1.6 0.5 0.8 1.1 1.7 2.31 YER120W 0.9 1.1 2.5 0.8 0.8 1.5 0.9 0.6
0.8 0.9 1.1 1.3 1.0 0.9 1.5 1.0 1.2 1.0 1.52 YFL011W 1.2 0.7 3.7
3.3 1.3 1.0 0.8 0.8 0.3 1.6 2.1 0.9 0.8 0.8 1.7 1.2 0.8 1.0 1.25
YGL012W 1.0 0.8 3.0 1.2 1.5 1.6 0.9 0.8 0.3 0.9 0.6 0.6 0.3 0.8 0.6
1.2 0.9 1.1 4.88 YGR191W 0.8 0.7 1.6 1.5 0.8 1.1 0.7 0.7 0.1 0.7
1.6 0.7 1.0 0.7 1.5 0.7 0.8 0.8 1.58 YGR204W 0.5 1.1 2.7 1.3 0.6
0.6 0.8 0.4 0.9 2.3 2.1 1.0 1.3 0.5 1.6 0.6 1.0 0.7 1.49 YHR025W
0.6 0.8 2.4 0.6 0.9 0.8 0.8 0.8 0.2 0.4 2.1 0.9 0.7 0.6 2.1 0.5 1.0
0.6 0.68 YHR123W 0.7 1.2 1.8 1.0 1.0 0.9 0.8 0.8 1.1 1.2 0.7 1.5
0.8 2.3 0.5 1.1 1.0 0.85 YJL121C 1.0 0.5 1.9 0.8 1.0 1.1 0.7 1.0
0.1 0.4 1.1 0.6 0.7 0.9 1.0 0.6 1.1 1.0 1.00 YJR077C 1.1 1.1 2.0
1.6 0.9 0.9 0.7 0.8 0.4 0.7 1.6 1.0 0.9 0.7 1.5 0.7 1.0 0.8 1.79
YJR143C 0.6 0.6 2.1 0.8 1.6 0.6 0.5 0.7 0.1 0.3 1.3 0.6 0.3 0.6 1.1
0.5 0.7 0.8 3.24 YKL060C 1.6 0.8 2.5 1.0 1.6 1.3 1.2 1.1 0.3 0.8
2.1 1.3 1.2 0.8 1.6 1.5 1.2 1.7 6.01 YKL148C 0.9 0.8 3.7 0.7 0.8
0.5 0.6 0.8 1.7 1.7 1.5 0.8 0.8 0.8 0.6 1.1 0.8 1.0 0.54 YKL157W
0.7 1.0 2.3 1.3 1.5 1.5 1.9 1.1 1.7 1.9 1.5 1.0 2.3 0.8 1.2 1.7 1.2
1.5 1.22 YLR044C 0.8 0.6 2.2 0.9 1.7 1.5 1.3 0.7 0.0 1.2 1.1 1.4
1.7 0.5 2.2 0.6 0.9 0.9 5.16 YLR056W 1.0 0.6 2.5 0.8 1.6 1.2 0.8
0.9 0.0 0.5 0.8 0.9 0.2 0.7 0.9 2.1 1.1 1.1 3.61 YLR058C 0.9 0.8
5.5 2.6 0.7 0.9 0.5 0.3 0.2 0.1 2.6 0.4 0.3 0.7 1.5 0.4 0.8 0.8
2.71 YLR081W 1.3 0.8 2.8 3.6 1.0 0.9 0.7 0.9 0.1 2.2 2.6 1.0 0.6
1.0 0.7 1.2 0.7 0.9 1.46 YLR089C 0.9 1.2 2.1 0.9 0.8 1.5 1.6 0.7
0.5 0.8 1.7 0.6 1.0 0.7 1.7 1.4 1.2 1.3 1.27 YLR284C 0.9 1.0 3.8
1.9 1.6 0.9 0.8 1.2 0.9 0.9 1.5 0.6 0.8 1.3 1.0 4.5 2.9 8.1 0.84
YLR304C 0.7 0.6 5.0 0.7 0.6 1.9 0.6 0.6 0.1 2.2 1.6 1.0 0.5 0.7 1.6
1.8 0.5 0.7 2.39 YLR354C 1.1 2.5 2.3 1.5 1.6 1.5 1.1 1.4 0.4 0.9
1.7 1.2 1.0 0.9 2.4 1.3 1.0 1.5 4.53 YLR372W 0.7 0.3 1.7 0.8 1.4
0.5 0.2 0.9 0.0 0.1 0.9 0.6 0.1 0.6 0.7 0.2 0.5 0.6 4.46 YML022W
0.9 0.6 2.0 1.1 1.3 0.8 0.6 1.1 0.3 0.6 1.2 0.6 0.2 0.9 0.6 0.6 0.5
0.7 4.93 YMR011W 1.3 1.0 9.4 5.5 0.9 0.6 0.8 1.1 0.0 0.7 1.5 0.8
0.4 0.6 0.6 1.2 1.3 1.6 4.95 YMR015C 0.7 0.7 1.9 0.9 1.7 1.3 0.4
0.7 0.1 0.3 1.0 0.9 0.4 0.8 1.2 1.5 1.0 1.0 2.51 YMR205C 0.5 0.7
2.3 0.8 1.2 1.2 0.9 0.7 0.3 0.8 1.0 1.1 1.3 0.5 0.9 0.9 0.6 0.5
4.75 YMR261C 0.7 1.6 3.6 0.8 0.9 0.6 1.3 0.7 1.6 1.3 0.8 0.9 1.6
0.6 0.8 1.6 0.7 1.1 0.78 YMR323W 0.8 1.1 2.9 1.1 0.7 0.4 1.1 0.8
0.5 1.3 2.5 1.2 1.8 1.2 37.3 0.6 1.1 0.6 1.04 YOL086C 1.1 0.5 2.2
1.1 1.9 1.7 1.9 0.8 0.1 1.2 2.6 1.3 1.7 0.6 1.6 1.4 1.1 1.3 4.19
YOL156W 1.1 0.7 2.5 1.1 1.2 1.2 1.0 1.0 2.3 2.1 1.1 0.9 1.7 0.9 1.9
0.9 0.9 0.9 0.53 YOR002W 0.8 1.1 1.9 0.9 1.1 1.1 1.0 0.9 0.8 0.9
1.2 0.5 0.6 0.9 1.5 0.8 0.9 1.1 1.49 YOR085W 0.7 0.8 1.9 1.0 1.0
0.6 0.6 0.7 0.5 0.6 1.1 0.8 1.0 0.7 1.8 0.8 0.9 0.9 1.86 YOR108W
0.8 0.9 2.3 0.6 1.1 1.6 1.2 0.9 0.4 1.1 1.4 0.7 1.3 0.9 0.7 1.0 1.1
1.1 1.07 YOR128C 0.9 0.7 2.1 2.1 1.1 1.0 0.7 0.6 0.3 0.4 0.8 0.5
0.4 0.7 1.6 0.5 1.2 1.2 2.14 YOR142W 1.0 1.2 3.4 1.0 1.4 1.6 1.0
0.8 1.1 1.5 1.5 0.8 1.4 0.8 1.1 0.8 0.9 1.0 1.31 YOR176W 0.7 2.6
2.7 0.9 1.0 0.9 0.5 1.0 1.0 0.5 1.4 1.3 1.5 0.8 0.8 1.4 1.2 2.1
1.23 YPL057C 1.9 1.1 3.2 3.1 1.9 0.6 0.6 1.0 0.4 1.4 1.6 1.0 1.3
0.7 1.1 2.5 2.2 2.0 2.08 YPL135W 0.9 1.2 2.5 1.2 1.6 1.3 1.2 1.0
0.5 2.8 1.3 1.1 1.2 1.1 1.5 1.2 1.5 1.7 1.50 YCR010C 1.6 1.6 1.6
4.2 1.7 1.3 1.3 0.8 0.9 4.7 1.1 0.8 1.0 1.2 1.2 2.8 1.9 1.5 0.26
YBR003W 0.9 0.8 1.0 1.9 0.7 1.2 1.1 0.9 1.0 1.3 1.3 0.8 1.2 0.8 0.7
2.0 1.1 1.3 1.06 YBR020W 1.0 0.5 1.9 1.9 1.0 0.8 0.7 1.0 -0.4 1.1
1.0 0.8 1.1 1.0 1.3 0.7 0.8 0.9 0.27 YDR123C 1.2 0.8 0.4 2.1 1.6
0.7 0.9 1.3 0.5 0.6 0.6 0.5 0.9 0.7 1.2 0.8 1.3 1.0 0.30 YDR277C
1.6 1.2 1.0 3.0 0.8 1.1 1.2 1.7 0.2 0.9 1.2 0.9 1.2 1.3 0.4 2.3 1.2
1.7 0.89 YDR408C 1.0 1.0 1.4 4.1 0.9 0.9 0.8 0.7 0.3 0.5 1.7 0.6
0.5 0.9 1.0 1.0 1.1 1.1 2.16 YDR483W 1.1 1.0 1.3 2.0 0.7 1.5 0.8
1.0 0.4 1.1 1.4 0.8 1.3 0.8 1.5 1.2 1.2 1.4 3.24 YGL115W 0.9 0.6
1.2 2.0 1.2 1.2 1.4 1.0 1.2 1.2 1.0 0.9 0.7 1.2 0.7 1.7 0.8 1.2
2.46 YGR096W 1.5 1.0 1.1 4.6 1.2 1.7 0.9 1.0 0.8 0.8 0.8 0.8 1.1
1.2 0.9 0.8 0.8 1.0 0.49 YGR288W 0.9 0.5 1.0 2.6 0.8 1.4 1.0 1.6
2.6 1.3 0.9 1.3 1.1 0.8 1.7 1.2 1.3 0.41 YHR210C 1.3 1.0 0.6 5.2
1.8 0.7 1.9 1.3 -0.1 0.9 1.5 0.5 0.4 1.0 0.5 1.5 1.4 1.2 0.33
YIL006W 1.0 1.1 1.4 2.9 0.8 0.3 0.8 0.6 0.9 1.1 1.0 0.9 0.8 1.0 1.5
1.7 0.8 0.9 0.28 YKR034W 0.9 1.5 1.1 4.7 0.9 0.9 0.7 1.5 0.5 0.6
0.0 0.7 1.2 1.1 1.7 0.6 0.8 1.0 0.26 YLR006C 0.7 0.7 0.9 6.2 1.6
0.9 1.1 0.9 1.1 1.1 1.5 0.7 0.8 1.0 0.9 0.8 1.6 1.0 0.40 YNL025C
0.9 1.4 1.4 12.8 0.7 0.5 1.2 1.0 1.1 1.8 1.1 0.8 1.3 1.2 1.4 2.9
0.7 1.3 0.37 YOL116W 1.1 1.0 0.9 2.8 1.7 0.7 1.5 1.3 0.6 1.8 1.0
0.6 0.8 0.9 0.7 1.9 1.1 1.4 0.47 YOR103C 1.1 0.8 1.3 1.8 1.5 1.0
1.2 1.0 0.8 0.9 1.0 1.2 0.8 1.2 1.4 1.3 1.1 1.5 2.84 YOR251C 1.1
1.0 1.3 1.8 0.8 0.9 1.0 1.1 0.8 0.8 1.0 0.9 1.0 1.1 0.6 1.2 0.9 1.3
1.34 YOR348C 1.1 0.7 1.2 2.0 0.9 0.7 0.8 0.8 0.5 0.4 1.1 0.7 1.1
1.2 1.6 1.7 0.9 0.9 0.18 YPL148C 1.2 0.8 0.9 2.3 1.1 0.6 1.0 0.9
0.7 1.5 3.5 0.7 0.6 1.6 0.6 1.6 1.0 1.1 0.48 YGL205W 0.9 0.9 0.7
0.8 1.1 1.6 0.8 1.2 0.5 0.6 0.4 1.1 1.0 1.0 2.0 4.1 3.9 9.1 0.24
YNL192W 1.1 1.2 1.5 1.6 0.9 0.6 1.0 0.8 0.6 1.8 1.1 1.1 2.7 0.7 2.1
0.8 2.3 2.8 1.31 YOL108C 1.4 1.5 0.4 1.9 2.1 0.9 1.1 1.3 1.6 0.9
1.1 1.0 1.3 0.9 1.5 1.8 1.5 2.7 0.87 YPR165W 1.3 0.7 1.6 1.0 1.5
1.8 1.0 1.0 0.9 0.7 1.0 0.8 1.0 1.0 0.9 1.0 2.3 2.7 3.64 YDR073W
1.7 0.9 0.7 1.4 1.2 1.3 1.2 1.3 0.5 1.2 1.0 0.8 0.6 1.2 0.8 1.6 1.8
2.3 1.27 YER015W 0.7 0.9 1.1 1.5 1.3 0.9 1.2 1.1 0.4 0.9 1.0 0.9
0.8 1.1 0.8 3.0 1.6 2.6 0.41 YJL167W 0.9 1.4 1.4 1.1 0.7 1.3 1.5
1.5 0.9 0.9 1.2 1.3 0.9 0.9 1.6 1.4 1.4 2.1 2.94 YJL216C 0.8 4.7
2.2 0.9 0.8 1.5 1.9 1.5 1.3 1.1 1.0 1.1 1.1 1.2 1.5 1.2 2.0 0.25
YKR009C 1.0 1.2 1.5 0.9 1.0 1.8 1.0 0.9 2.4 2.1 1.2 1.0 1.8 1.0 1.0
4.6 1.9 2.5 0.27 YOR180C 0.8 1.1 1.0 1.0 1.0 0.7 0.8 0.9 0.3 0.4
0.6 0.8 0.9 1.0 1.1 2.4 0.9 2.3 0.55 YBR036C 0.8 1.7 1.8 1.2 1.2
1.3 1.3 0.7 1.0 1.0 1.5 1.0 1.9 0.8 1.5 1.6 2.1 1.8 2.05 YDR297W
1.5 0.8 0.8 1.1 0.9 1.4 0.6 1.5 0.3 0.7 1.4 1.0 0.8 0.9 1.4 1.4 1.9
1.9 1.73 YDR387C 0.8 0.9 1.2 2.2 0.9 1.2 1.3 0.7 1.4 2.0 2.0 0.9
1.3 0.9 1.4 2.7 1.2 1.1 0.86 YOL096C 1.1 1.0 1.2 1.6 1.2 1.3 1.7
1.0 1.3 1.4 1.2 1.2 1.4 1.4 1.0 2.3 1.2 1.2 0.64 YPR184W 1.2 1.4
5.7 2.2 0.9 1.5 1.3 0.7 1.9 3.2 3.6 1.4 2.5 1.3 1.5 3.1 1.0 1.7
0.37 YBR298C 1.1 1.0 1.6 2.3 1.4 0.4 1.7 0.5 0.3 1.1 1.5 1.1 0.8
0.9 0.2 2.1 0.9 0.8 0.88 YDL078C 0.7 1.1 1.2 0.8 1.3 1.1 1.7 1.0
1.1 1.0 1.7 0.8 1.0 0.8 0.5 2.2 1.1 2.0 1.65 YDL215C 1.0 1.5 1.0
1.6 1.5 0.9 1.9 1.1 1.7 2.4 0.8 0.8 1.5 1.0 1.1 2.2 1.1 1.6 0.91
YGL035C 0.7 1.4 4.3 1.4 1.1 0.6 1.2 1.3 0.9 1.5 1.3 0.9 1.1 1.1 1.0
2.3 0.9 1.2 0.61 YGR287C 1.3 1.0 1.3 1.5 0.8 0.8 2.2 1.3 2.6 4.2
1.5 1.1 1.7 1.1 2.3 3.0 1.0 1.1 0.38 YJL070C 1.3 0.9 1.1 1.2 1.3
2.0 1.4 1.1 1.0 1.1 1.3 1.0 1.8 1.3 3.5 2.2 1.1 1.2 0.34 YLR351C
1.0 1.4 1.3 1.5 1.3 1.4 1.4 1.2 0.8 1.2 1.1 0.9 0.9 1.4 1.2 2.0 1.3
1.8 1.75 YLR375W 0.9 1.5 0.9 0.9 1.0 1.3 0.9 1.0 1.6 1.2 1.6 0.9
1.6 0.9 1.3 2.2 1.0 1.0 1.05 YMR267W 0.8 1.8 0.7 0.9 1.0 1.4 1.2
1.5 0.4 0.8 1.0 0.8 0.7 1.0 0.9 2.6 0.9 1.3 0.94 YMR278W 0.7 1.7
1.4 1.0 1.2 1.3 1.8 1.1 1.4 1.7 1.1 1.0 2.5 0.8 1.8 2.5 1.0 1.5
0.62 YMR293C 0.9 1.5 1.6 2.2 0.6 0.5 1.2 1.0 0.7 1.3 0.4 0.9 0.8
1.3 0.7 2.2 0.8 1.0 0.37 YNR072W 1.1 1.5 0.5 0.7 1.0 0.9 1.5 0.9
0.7 1.8 1.4 1.0 1.5 1.0 1.8 2.1 1.3 1.0 0.26 YOR363C 0.8 2.0 0.9
1.3 0.7 1.2 0.7 1.1 1.2 1.6 1.2 0.9 1.3 0.9 1.1 2.1 1.3 1.8
0.40
[0032] TABLE-US-00009 TABLE 8 Detoxification protein genes The
level of expressed mRNA in the presence of chemical substance/The
level of expressed mRNA in the absence of chemical substance yeast
genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14)
(15) (16) (17) (18) Intensity YDR453C 1.1 2.7 4.4 3.0 0.7 1.7 1.0
1.3 4.5 6.1 2.3 0.9 1.4 3.8 2.3 5.6 1.0 1.5 1.53 YLL060C 12.5 4.2
2.3 2.6 0.9 1.4 2.0 5.8 13.0 23.2 14.1 1.1 1.8 10.6 1.5 3.6 1.9 2.3
0.57 YBL064C 2.6 2.8 3.9 1.7 0.8 5.2 2.5 2.4 4.5 3.8 2.9 1.7 4.1
5.0 1.3 5.0 1.2 2.3 1.67 YBR008C 3.0 2.4 4.9 0.7 0.9 1.0 0.9 2.8
54.6 21.1 9.4 0.8 2.0 4.1 0.8 3.1 2.0 1.2 0.37 YOR153W 1.6 0.9 5.1
1.1 1.0 7.4 2.6 0.5 3.2 1.2 1.0 4.0 11.8 0.3 3.6 1.6 2.5 3.1 1.91
YHL047C 0.6 4.4 1.0 1.0 1.2 8.4 16.8 1.5 1.2 11.9 1.0 2.6 3.8 0.5
1.1 2.3 1.2 1.2 0.74 YCL035C 2.0 2.3 1.5 1.7 1.5 5.1 2.7 1.4 1.9
2.3 2.1 1.5 2.8 2.5 1.9 5.5 2.6 4.2 1.74 YGR197C 1.1 2.4 2.5 1.0
0.7 0.5 1.3 0.8 16.7 3.2 1.1 1.2 2.4 1.5 1.0 1.5 1.7 1.9 0.37
YHR055C 4.4 1.8 0.8 1.2 2.7 1.6 1.1 2.1 3.9 3.3 1.8 1.2 3.0 1.5 0.5
0.8 0.9 0.6 3.96 YNL239W 1.0 2.4 2.4 1.2 1.2 1.8 2.1 1.3 2.5 6.0
1.9 1.5 3.6 1.3 1.7 1.5 1.1 1.4 0.68 YNL241C 1.3 2.5 4.3 1.0 0.8
0.9 3.2 0.9 3.4 7.4 3.0 2.0 4.9 1.1 7.0 2.8 1.0 1.0 0.68 YBR293W
1.9 3.1 1.0 1.8 0.8 0.9 0.9 0.9 5.5 2.4 1.1 1.0 3.0 1.4 3.1 1.6 1.0
0.9 0.94 YDL100C 1.0 1.2 1.1 0.8 1.0 2.1 1.6 1.7 5.4 3.2 2.8 1.5
2.5 1.4 1.0 1.3 1.2 1.4 2.60 YER185W 2.0 3.1 2.1 7.0 1.6 1.2 1.1
1.0 2.9 1.2 1.6 1.1 2.1 1.6 1.7 0.6 2.6 1.1 0.26 YGL013C 0.9 1.2
0.8 0.7 1.1 2.3 0.9 1.4 3.0 1.5 0.9 1.0 2.3 0.8 1.0 0.9 1.1 1.0
0.43 YHR053C 3.5 2.1 0.7 1.1 2.9 1.3 1.2 2.2 4.5 2.9 1.4 1.1 1.9
1.5 0.3 0.7 1.0 0.5 3.99 YIR038C 1.3 3.5 4.6 2.0 0.7 2.5 2.0 1.3
4.6 4.5 3.4 1.1 2.5 2.5 1.2 6.0 2.8 2.0 1.11 YKL026C 2.7 2.0 1.2
4.9 1.0 1.8 2.5 1.8 7.5 3.0 3.0 1.0 2.3 1.8 0.8 6.6 1.6 3.3 0.61
YLL028W 0.6 0.9 4.6 0.5 0.9 1.7 1.0 0.7 1.2 2.3 0.7 1.3 4.1 0.7 3.1
0.6 1.2 1.2 1.02 YOR273C 0.7 1.0 1.7 1.0 1.1 0.4 0.4 0.6 0.6 0.5
1.5 0.8 2.6 0.5 0.8 0.6 3.2 3.1 1.20 YGR138C 1.1 1.6 1.0 1.2 0.8
0.8 0.7 1.0 0.5 1.0 0.7 0.6 0.6 0.9 4.5 0.7 0.7 0.7 1.24 YOR247W
1.7 0.6 3.6 1.4 0.6 0.2 0.5 0.7 0.1 0.4 2.9 0.6 0.3 0.4 7.3 0.2 1.2
0.9 2.23 YPL163C 0.6 0.7 1.4 0.9 0.6 0.6 0.4 0.5 0.1 0.4 0.5 0.9
0.4 0.6 5.3 0.6 1.4 1.4 1.05 YHL040C 1.6 4.4 1.5 0.4 1.1 7.3 4.0
1.5 1.1 11.3 1.7 2.0 2.0 1.1 3.4 1.0 1.4 1.0 0.69 YEL065W 0.3 3.8
1.2 0.4 1.4 2.3 4.3 0.9 0.1 4.9 0.6 1.7 0.8 0.4 2.2 2.6 0.7 0.6
2.10 YIR002C 0.8 1.1 0.5 0.6 1.2 2.2 1.3 1.2 1.7 1.4 0.8 1.3 1.2
1.1 1.1 1.4 1.1 1.2 0.58 YNL259C 1.6 4.5 1.1 1.2 1.1 3.9 3.8 1.5
1.6 2.1 1.6 0.7 1.1 1.4 0.7 1.7 2.6 2.4 1.22 YBR145W 1.5 0.7 2.8
0.9 1.1 11.5 58.8 1.0 0.1 1.1 1.1 1.0 2.0 2.2 1.2 3.6 1.7 2.0 2.17
YLR043C 1.4 1.4 2.0 1.8 2.0 1.4 2.6 1.1 2.8 2.5 1.4 0.8 2.0 2.1 0.5
1.8 1.5 2.2 2.12 YGR209C 1.6 3.1 3.5 1.5 1.9 1.9 1.7 1.6 2.4 6.3
3.1 0.9 1.4 5.0 1.3 1.9 1.3 2.4 3.17 YDL168W 2.3 2.0 2.1 0.9 1.2
1.4 1.1 1.7 8.2 4.7 1.9 0.6 1.3 1.6 1.2 1.1 0.9 0.8 1.08 YDR513W
2.2 2.5 2.3 2.6 0.9 2.1 1.6 1.6 4.6 3.1 2.0 0.9 1.8 2.0 1.3 3.8 1.3
3.2 3.10 YGR088W 1.3 1.2 7.7 2.4 1.0 1.3 0.8 0.8 1.5 3.2 3.9 1.1
1.2 1.3 0.7 5.6 0.9 2.0 0.75 YHR048W 2.5 1.4 1.4 1.7 1.0 0.8 0.8
1.9 4.5 2.7 2.0 0.9 1.1 1.7 0.9 1.4 0.7 0.9 0.26 YJL101C 2.1 1.9
2.1 1.2 1.4 1.0 1.0 1.3 3.1 3.6 2.7 0.7 1.0 1.0 0.5 1.3 0.9 1.0
1.13 YML116W 4.1 1.3 1.5 1.4 1.2 0.9 1.4 2.2 1.4 3.1 4.3 0.5 0.8
2.0 1.9 1.0 1.0 1.0 0.94 YMR038C 1.9 1.7 1.8 0.8 1.5 1.0 1.1 1.9
2.4 2.6 2.7 0.9 1.7 1.1 0.6 1.5 1.2 1.3 1.76 YBR244W 0.6 1.4 2.0
0.9 1.7 1.0 0.6 1.0 1.4 3.0 1.5 0.5 0.4 3.7 0.4 0.7 1.2 1.2 3.42
YCL069W 0.9 15.7 0.9 0.8 0.9 1.4 1.3 1.2 6.9 1.0 0.9 0.8 1.3 1.4
0.9 1.0 1.0 0.25 YKR105C 0.8 0.9 0.9 1.5 1.0 1.2 1.0 1.3 1.0 5.2
0.0 0.8 2.5 1.2 1.5 0.7 0.8 1.0 0.26 YOL158C 0.7 4.0 2.4 0.9 1.2
2.0 1.6 0.7 1.7 6.1 0.7 0.9 1.4 1.0 0.9 1.2 1.4 1.7 1.30 YDR256C
0.8 1.4 0.7 1.3 1.2 0.5 0.6 0.8 5.2 2.0 1.4 0.8 1.1 1.6 1.0 4.3 1.0
2.0 0.30 YGL254W 1.2 1.1 0.8 0.6 1.1 0.7 1.3 1.4 3.1 1.8 1.1 1.2
2.4 1.3 1.1 1.4 0.8 1.2 0.53 YKL064W 0.6 0.9 0.4 0.8 1.2 1.5 1.1
0.9 2.4 1.6 0.7 0.7 1.6 1.1 0.7 1.4 1.3 1.3 0.60 YLL057C 2.2 59.9
1.8 0.9 1.1 1.0 1.6 1.4 121.8 2.9 1.3 0.7 1.4 1.1 1.4 0.9 3.0 1.3
0.19 YPR200C 47.7 1.7 0.8 5.0 1.6 0.8 1.3 1.4 4.7 3.8 2.0 0.4 0.6
2.0 0.7 1.2 1.1 1.0 0.27 YJR104C 1.4 1.8 2.9 1.2 1.5 1.4 1.1 1.5
1.9 2.8 2.6 0.9 0.9 2.0 1.3 2.9 0.9 1.1 3.50 YKR106W 1.3 0.8 2.1
1.4 1.2 1.6 0.9 1.3 10.5 7.4 1.8 0.8 1.4 1.7 2.8 0.9 0.8 0.16
YOR031W 2.6 1.7 1.3 3.4 1.4 0.9 1.3 0.9 0.7 1.3 1.2 0.8 1.8 1.5 1.4
6.2 1.7 2.4 0.52 YHR008C 1.3 6.9 4.8 1.8 0.6 1.0 0.7 0.9 1.7 2.4
2.1 0.7 1.2 1.6 1.7 2.2 0.9 1.0 1.04 YML028W 1.0 2.2 4.4 1.3 1.6
1.2 0.8 0.8 0.8 1.8 1.0 1.6 1.6 2.0 2.2 1.3 1.1 1.5 4.85 YEL027W
1.2 0.6 3.4 1.1 1.0 1.1 0.8 0.9 0.9 1.1 0.9 0.9 0.7 1.4 1.5 1.6 1.0
1.4 4.75 YKR066C 0.9 1.4 5.5 0.7 1.0 0.9 0.5 0.7 0.7 2.4 1.3 0.9
0.6 1.5 0.6 1.3 0.9 1.1 1.25 YDR538W 0.9 1.1 2.4 1.2 1.0 1.0 1.2
1.0 0.3 0.8 0.9 0.7 0.7 0.9 1.0 0.9 1.0 0.9 0.53 YMR015C 0.7 0.7
1.9 0.9 1.7 1.3 0.4 0.7 0.1 0.3 1.0 0.9 0.4 0.8 1.2 1.5 1.0 1.0
2.51 YOR251C 1.1 1.0 1.3 1.8 0.8 0.9 1.0 1.1 0.8 0.8 1.0 0.9 1.0
1.1 0.6 1.2 0.9 1.3 1.34 YLR046C 0.7 1.7 0.9 0.8 1.0 3.8 1.5 0.5
1.0 1.4 0.9 0.8 1.2 1.3 0.8 1.3 5.2 5.4 0.86 YGR224W 0.9 1.2 1.2
1.2 1.4 0.8 0.4 0.6 0.9 0.9 0.8 0.6 0.8 0.9 1.1 1.0 2.8 1.3 0.27
YFL050C 0.7 1.0 1.1 2.2 1.0 0.9 0.8 0.9 0.5 1.6 1.2 0.9 1.2 1.0 1.4
2.3 0.8 1.0 0.36 YCR083W 1.1 2.8 1.5 1.8 1.6 2.4 1.8 1.5 1.8 1.8
1.8 1.1 1.8 2.4 1.0 3.1 1.3 1.3 0.98
[0033] TABLE-US-00010 TABLE 9 Genes belonging to other category The
level of expressed mRNA in the presence of chemical substance/ The
level of expressed mRNA in the absence of chemical substance yeast
genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14)
(15) (16) (17) (18) Intensity YKR076W 5.0 2.6 3.5 2.2 1.0 4.7 4.9
6.2 43.4 43.1 18.6 1.5 5.1 14.7 3.2 9.6 1.8 2.7 0.27 YNL335W 1.2
0.7 1.5 2.3 1.5 1.6 1.3 1.7 1.6 5.3 1.1 0.8 0.9 4.6 1.7 1.0 1.2 1.1
0.22 YBR173C 1.1 2.4 3.4 1.6 0.7 1.3 1.6 1.2 6.0 5.1 2.5 1.7 3.8
3.0 15.4 2.1 0.9 1.6 1.15 YFL022C 0.8 0.9 1.5 0.6 0.7 0.9 0.3 0.8
0.5 0.5 1.2 0.6 0.6 3.1 1.1 1.3 0.9 0.8 1.07 YGL158W 1.1 2.8 1.9
12.9 1.0 0.4 1.3 1.3 -0.4 0.9 0.2 1.3 1.0 2.3 2.3 8.2 0.8 1.1 0.18
YHR139C 3.0 4.6 6.8 9.3 1.3 1.9 1.5 1.3 107.2 46.6 3.5 1.6 7.0 2.5
1.9 17.1 1.4 1.3 0.34 YGR213C 5.4 2.9 1.0 6.8 1.2 4.1 7.0 2.0 7.5
6.9 1.6 10.6 30.4 1.0 6.5 5.2 12.8 8.5 0.22 YKL165C 0.5 2.0 1.1 0.6
0.9 0.6 2.1 1.5 0.4 0.4 0.3 2.4 3.2 0.8 2.1 1.2 0.9 1.0 1.08
YBL005W-A 1.0 0.9 0.5 0.9 1.3 1.2 1.4 1.0 0.8 1.5 0.8 1.6 2.9 1.4
0.9 1.1 1.3 1.0 0.48 YBL041W 1.2 1.4 0.9 1.0 1.6 1.7 1.6 1.7 2.8
2.6 1.6 1.6 2.6 2.0 1.3 2.3 1.3 2.0 3.03 YBL078C 2.3 2.7 1.3 2.6
0.7 2.4 3.1 1.6 12.3 15.2 4.6 3.1 5.0 3.6 2.5 4.4 1.8 2.8 0.65
YCL020W 1.1 2.5 0.5 1.1 0.5 1.0 1.5 1.7 0.9 2.4 1.3 1.5 3.0 1.7 2.5
1.3 0.9 1.3 1.46 YDL007W 0.8 1.4 1.3 0.9 1.0 1.1 1.2 1.4 3.8 2.4
1.3 1.1 2.4 1.4 1.4 0.8 0.8 1.5 2.43 YDL097C 0.9 1.7 0.9 1.2 0.8
1.3 1.6 1.5 4.5 2.3 1.5 1.3 4.0 1.4 1.1 1.1 1.0 1.3 2.06 YDL126C
0.5 1.4 2.3 0.7 0.9 1.2 1.5 0.8 2.7 2.0 1.4 1.3 4.3 0.6 1.7 0.7 0.9
0.9 3.24 YER012W 1.4 1.2 1.2 1.0 1.9 2.4 2.4 1.8 6.7 2.7 1.9 1.5
2.9 4.6 1.7 2.2 1.5 1.3 1.84 YFR010W 1.1 1.1 0.8 1.2 0.9 1.3 1.4
1.6 4.3 3.4 1.5 1.2 3.7 1.1 1.5 1.3 0.9 1.4 1.89 YFR024C 0.8 25.0
2.3 1.1 0.7 1.4 3.0 0.9 5.3 4.1 1.9 1.5 2.8 1.2 0.9 1.9 1.0 1.4
1.06 YGL048C 1.0 1.3 0.7 1.3 1.8 1.5 2.0 1.5 2.4 2.1 1.5 1.3 2.5
1.2 1.0 1.6 1.4 2.0 3.07 YGL141W 0.8 1.2 1.1 0.7 1.4 3.0 1.7 0.8
4.5 1.9 0.6 1.4 3.6 1.2 1.5 1.2 1.4 1.2 0.44 YGL180W 1.3 1.3 1.7
0.6 1.2 1.1 2.4 1.2 7.2 3.7 1.3 1.4 2.6 1.0 1.3 1.7 1.0 1.1 0.28
YGR048W 0.7 2.7 1.4 1.3 1.0 1.0 1.9 1.4 4.4 3.1 1.1 1.1 2.5 1.3 0.8
1.1 0.9 1.2 0.93 YGR135W 1.0 1.0 1.0 1.1 1.6 1.5 2.2 1.8 1.5 2.3
1.6 1.2 2.8 2.6 1.5 1.5 1.0 1.9 3.10 YGR201C 1.7 11.9 2.4 2.0 0.8
3.1 2.6 1.6 5.4 3.5 1.6 1.9 8.6 1.6 0.5 14.4 1.4 2.1 0.60 YHL030W
0.5 0.8 1.0 0.7 0.7 1.9 0.9 0.8 2.7 2.5 1.1 1.1 3.8 1.0 2.0 0.5 0.8
0.9 0.66 YHR166C 0.9 1.1 1.0 0.7 1.0 1.8 1.5 1.0 2.6 1.2 0.6 1.7
6.9 1.2 0.9 1.1 1.4 1.5 1.35 YJR069C 0.8 0.8 0.9 0.6 0.9 1.2 1.3
0.9 0.7 0.6 0.9 1.1 3.9 0.6 0.4 0.8 1.0 0.9 1.73 YKL073W 0.6 1.4
0.5 0.6 1.2 0.5 2.1 1.6 1.3 1.1 0.5 1.5 3.3 0.7 1.6 1.0 1.2 1.5
1.29 YKL103C 1.6 4.1 2.5 2.1 0.9 2.7 2.8 1.6 8.3 9.9 2.8 1.3 3.8
2.0 2.1 1.2 1.9 2.2 0.56 YLR080W 1.0 1.4 1.2 1.7 1.1 2.5 2.8 1.3
2.3 1.5 1.9 0.8 3.6 1.2 0.7 3.0 1.6 2.2 0.41 YLR107W 1.2 0.9 0.5
1.2 1.7 2.3 1.6 1.1 1.8 1.2 0.8 1.0 2.9 1.6 1.1 1.6 1.8 2.4 0.94
YLR121C 1.7 1.7 1.1 1.2 1.0 1.6 1.3 2.2 2.0 2.2 1.1 4.0 1.2 10.7
1.5 2.7 1.4 0.30 YLR336C 0.6 0.8 0.7 0.4 0.9 0.8 1.8 1.0 -0.3 0.5
0.5 1.9 4.6 0.6 0.8 1.3 1.5 1.0 0.71 YLR370C 1.1 1.0 1.1 1.4 1.4
4.1 2.1 0.8 1.5 1.9 1.0 1.2 3.1 1.9 1.5 1.6 1.6 2.0 1.41 YLR423C
1.2 1.2 0.7 1.9 1.5 1.2 3.8 2.0 1.2 1.0 1.0 1.7 3.9 1.2 1.3 1.9 1.2
1.6 0.34 YML092C 1.1 3.1 2.4 1.1 0.9 1.9 1.2 1.2 6.4 4.0 2.5 1.2
2.3 1.6 1.4 2.2 1.3 1.5 1.72 YML130C 1.5 2.7 5.3 1.2 0.9 0.6 2.9
2.7 7.8 4.2 1.9 2.3 5.8 1.3 2.4 0.8 1.2 1.2 1.59 YMR214W 0.8 3.8
1.0 1.4 0.8 0.9 1.0 1.1 2.1 1.0 0.7 1.0 2.4 1.1 4.8 0.7 1.1 1.0
0.88 YMR297W 0.7 2.0 3.6 1.9 0.6 1.8 1.2 0.8 1.9 1.0 2.5 1.2 4.2
0.5 2.4 1.9 1.1 1.4 4.10 YNL036W 2.0 1.9 3.2 1.0 1.6 1.1 2.0 2.1
6.6 5.0 1.7 1.4 3.3 5.1 1.6 1.3 1.4 1.9 2.04 YOL005C 1.4 1.4 1.1
0.8 1.6 1.1 1.1 1.0 0.9 1.0 1.6 1.2 2.9 1.2 0.9 1.0 1.2 1.2 1.71
YOR134W 2.0 3.6 1.0 9.5 0.9 1.4 1.1 1.5 1.5 8.2 1.9 2.8 4.4 1.3 1.6
7.7 2.2 4.6 0.28 YOR362C 1.0 1.7 1.0 0.8 1.7 1.4 1.6 1.4 4.3 3.0
1.3 1.3 2.5 1.4 1.0 1.5 1.1 1.8 2.55 YAR009C 0.8 1.3 0.6 1.0 1.4
1.6 2.7 1.4 0.9 1.4 0.9 1.3 2.0 1.0 2.1 0.6 0.8 1.2 7.11 YBL101C
1.0 1.1 1.9 0.9 1.0 0.9 0.8 0.8 3.0 1.4 0.8 1.1 3.5 0.9 2.7 1.4 1.0
1.1 0.39 YBR046C 1.4 1.4 1.7 1.8 1.3 2.6 3.9 1.6 4.6 6.2 2.9 1.2
2.0 1.3 2.1 3.0 1.2 2.0 0.63 YBR139W 1.2 1.4 3.1 1.4 0.8 2.4 1.9
0.7 2.3 1.6 2.3 1.2 2.7 1.1 5.6 2.3 1.2 2.0 1.21 YBR170C 0.8 1.2
0.6 1.4 1.5 1.4 1.9 1.3 6.1 4.2 1.5 1.2 2.7 1.3 1.9 1.3 1.1 1.4
0.72 YBR177C 0.8 1.1 4.0 1.2 1.2 2.3 0.9 0.9 2.1 1.7 0.6 1.2 3.1
1.3 1.4 0.4 0.8 0.9 0.76 YBR212W 0.7 1.2 2.6 1.2 1.0 1.4 0.9 0.6
2.7 2.3 1.1 0.9 2.2 0.7 1.0 1.5 1.1 1.0 0.95 YBR239C 1.0 1.3 0.9
1.5 0.8 1.5 1.0 1.3 0.4 1.2 0.7 1.1 1.9 1.1 1.0 2.7 1.0 0.9 0.31
YCL033C 1.1 2.0 1.7 1.7 1.2 4.6 2.4 1.1 2.3 1.4 1.9 1.6 2.0 1.8 0.8
3.6 2.0 2.0 1.14 YCR062W 0.8 1.9 2.7 2.8 1.4 1.9 0.9 0.7 0.7 1.3
1.2 1.3 2.2 1.0 2.3 1.1 1.1 1.0 0.41 YCR067C 0.9 0.7 1.2 1.3 0.7
0.8 0.8 0.7 1.8 1.6 1.2 0.9 2.0 0.9 2.1 1.4 1.1 0.9 0.62 YDL020C
2.3 1.2 3.4 1.1 1.2 2.5 1.0 2.2 5.6 2.9 1.9 1.1 3.4 1.2 1.5 1.8 1.5
1.7 1.36 YDR168W 1.2 1.4 1.0 0.8 1.5 1.3 2.4 2.1 3.7 2.3 1.5 1.2
2.4 1.4 1.9 1.4 1.2 1.4 1.28 YDR169C 1.0 1.4 1.1 1.3 1.3 1.2 1.1
1.0 1.6 1.4 0.9 0.9 1.9 0.9 1.4 0.9 1.4 1.1 0.40 YDR188W 0.8 1.2
1.0 0.8 0.8 0.8 0.9 1.0 2.9 1.6 0.9 0.9 1.7 0.7 1.3 0.9 0.7 0.8
1.78 YDR264C 0.5 2.6 0.9 1.4 0.9 1.8 3.2 0.8 1.1 3.4 0.9 1.1 2.1
0.7 2.3 1.5 1.2 1.4 1.63 YDR304C 1.0 1.8 2.7 1.3 1.5 2.1 2.0 1.3
3.9 1.9 1.2 1.3 2.3 1.7 1.0 4.0 1.6 1.8 2.23 YDR403W 1.0 1.2 1.6
1.0 1.2 1.1 1.2 1.2 4.1 3.6 1.0 1.0 2.0 1.1 0.9 0.9 0.9 1.0 0.35
YDR427W 0.8 1.1 0.8 0.8 1.5 1.9 1.4 1.2 2.3 2.0 1.2 1.1 2.1 1.0 1.3
1.1 1.0 1.5 2.37 YEL012W 1.3 1.8 1.0 1.8 1.7 1.6 4.7 1.4 4.6 4.2
2.2 1.2 2.2 1.9 1.1 2.5 1.5 2.2 0.74 YER009W 1.3 0.6 2.4 1.2 1.2
2.0 2.8 1.0 0.7 1.0 1.4 1.1 2.0 1.6 0.9 1.5 2.0 2.1 3.35 YER021W
0.8 1.0 0.9 0.9 1.4 1.1 1.5 1.2 3.0 2.2 1.3 1.0 1.8 1.3 0.8 1.4 0.8
1.5 2.02 YER094C 1.0 1.3 0.9 1.1 1.9 1.1 1.8 1.3 2.3 1.7 1.3 1.1
2.1 1.5 0.8 1.5 1.3 1.8 3.01 YER177W 1.4 1.5 2.1 1.5 0.9 1.6 1.2
1.1 1.8 1.7 1.9 1.1 2.2 0.9 1.4 1.0 0.9 2.0 5.81 YFL029C 1.0 1.2
1.2 1.8 1.7 1.0 1.6 1.5 4.3 2.9 2.1 1.1 1.8 1.9 1.3 1.2 1.2 1.4
0.49 YFL038C 1.0 1.2 0.7 1.3 1.5 1.3 1.7 1.4 2.1 1.9 1.7 1.1 2.1
1.5 1.5 2.1 1.2 1.6 2.31 YFR004W 1.0 1.5 0.8 1.4 1.0 1.5 1.3 1.4
3.6 2.6 1.3 1.2 2.0 2.1 1.1 1.3 1.0 1.4 2.44 YFR050C 0.9 1.2 1.1
1.3 1.7 1.5 1.4 1.4 3.1 2.1 1.4 1.5 2.1 1.6 1.5 1.5 1.1 1.7 1.70
YGL011C 1.2 1.5 1.1 1.1 1.8 1.6 1.5 1.3 2.0 2.2 1.5 1.0 2.1 3.0 1.3
1.7 1.3 1.5 1.78 YGL094C 0.8 1.3 0.3 0.9 1.3 1.0 0.8 1.0 1.4 1.1
0.6 0.8 2.3 0.9 1.9 1.0 1.0 0.9 0.51 YGL150C 0.7 0.8 1.2 1.0 0.8
1.1 0.8 0.8 1.4 0.9 0.4 0.8 2.4 1.0 1.3 0.9 0.9 0.8 0.62 YGL207W
0.5 0.6 0.9 0.6 1.3 0.9 0.6 1.0 1.4 1.1 0.7 0.7 2.5 0.8 1.2 0.7 0.9
0.8 0.88 YGR232W 1.2 1.2 1.2 1.7 1.5 1.9 2.0 1.1 3.4 2.2 1.3 1.1
2.4 2.1 0.9 1.8 1.3 1.2 0.96 YGR248W 1.3 1.7 3.2 4.0 0.5 2.3 1.1
1.2 2.8 3.2 2.3 1.1 2.0 1.5 1.5 7.9 1.0 1.5 0.52 YGR253C 1.3 1.4
0.7 1.3 2.0 1.4 1.6 2.0 4.0 3.1 2.4 1.1 3.4 1.8 1.1 1.8 1.5 2.1
2.01 YHR027C 0.5 0.8 1.2 0.6 1.1 0.4 0.9 0.6 3.6 2.2 1.1 1.0 2.1
0.7 1.5 0.9 0.8 1.0 2.06 YHR161C 0.6 1.1 1.3 2.1 1.5 1.2 1.8 0.7
2.5 2.0 1.2 1.0 1.8 1.0 1.4 1.7 1.4 1.5 0.86 YHR169W 0.6 0.5 0.4
0.4 1.1 1.2 0.9 0.9 0.0 0.2 0.4 1.1 3.3 1.1 0.6 1.0 1.6 1.3 0.81
YIL010W 1.0 1.2 1.4 0.8 1.2 4.4 1.5 0.9 1.4 2.2 1.4 1.4 2.3 1.7 1.1
1.7 1.5 1.5 0.70 YIL034C 1.0 0.8 1.5 3.0 0.7 1.7 1.2 0.9 2.1 1.3
1.6 1.0 2.6 1.1 1.0 1.7 1.2 1.5 0.99 YIL142W 0.7 1.1 0.9 1.1 0.8
1.1 0.8 1.1 4.4 3.0 1.7 1.1 1.8 1.0 1.3 0.7 0.9 0.8 1.84 YIR039C
1.4 1.8 4.3 4.2 1.5 3.2 4.1 1.1 4.4 4.1 3.8 1.4 2.9 1.9 2.0 4.2 1.2
1.1 0.45 YJL001W 0.9 1.7 1.2 2.0 1.7 1.6 1.3 3.1 2.8 1.5 1.6 2.9
2.5 1.2 1.8 1.0 1.6 3.00 YJL035C 0.9 1.3 0.8 0.6 1.4 0.7 1.3 1.5
1.7 1.4 0.8 1.1 2.4 1.6 0.7 0.6 1.0 1.0 0.82 YJL053W 1.1 0.9 1.7
1.3 1.1 2.0 1.7 1.3 2.2 2.2 1.6 1.1 1.9 1.3 1.1 1.7 1.3 1.6 0.80
YJL164C 1.1 1.1 1.0 1.9 1.1 2.7 3.1 0.9 2.1 0.8 1.5 1.0 2.1 0.9 0.8
2.1 1.3 1.7 1.04 YJL210W 1.2 1.4 1.6 2.0 0.6 0.6 1.0 1.0 2.0 0.9
2.4 1.0 2.2 0.9 0.8 2.3 0.9 1.0 0.70 YJR117W 1.0 2.1 2.3 0.7 1.2
1.3 1.0 0.8 4.7 2.3 1.0 1.2 2.8 0.8 2.2 0.7 0.8 0.9 1.34 YKL007W
1.2 1.6 1.2 0.9 1.0 0.9 1.5 1.2 2.3 2.4 1.8 1.3 2.5 0.7 1.0 1.0 1.4
1.3 1.13 YKL117W 1.0 1.3 0.8 1.0 1.8 1.0 1.3 1.5 2.9 2.1 1.6 1.0
2.4 1.6 1.6 1.8 1.2 1.8 3.73 YKL193C 1.3 0.8 1.1 1.4 1.1 0.9 2.1
1.4 1.0 1.6 1.7 0.9 2.1 1.2 1.2 2.4 1.2 2.3 0.71 YLR120C 1.2 1.9
2.4 1.6 1.1 1.9 1.5 0.9 1.8 1.6 1.2 1.6 4.8 0.8 2.7 1.7 3.5 2.9
1.53 YLR136C 1.3 9.0 0.6 3.3 1.6 1.7 3.9 1.1 0.9 6.0 1.2 1.3 2.9
0.7 2.1 1.2 1.8 1.4 0.41 YLR178C 1.7 6.9 8.8 4.6 1.0 4.2 3.3 0.9
4.3 4.1 3.7 2.2 7.5 2.8 2.3 10.6 2.0 3.6 1.03 YLR327C 5.5 3.3 14.4
8.2 1.3 5.1 5.7 2.2 3.0 8.3 5.0 1.4 2.8 1.5 0.8 2.8 3.3 5.3 2.23
YLR356W 1.0 2.9 4.9 1.2 1.1 3.4 1.1 0.7 2.3 1.6 3.1 1.5 2.5 2.2 2.8
0.9 1.1 1.0 0.41 YLR362W 1.1 1.2 1.0 3.0 1.5 0.8 1.9 1.4 3.5 3.3
1.5 0.8 2.4 1.2 1.3 1.9 1.2 1.3 0.35 YLR429W 0.7 1.0 0.6 0.9 1.4
0.8 1.3 1.0 0.9 1.3 0.9 1.1 2.3 0.7 1.5 1.0 1.0 0.9 0.86 YMR004W
0.9 0.9 1.3 1.3 1.0 0.5 1.2 1.0 94.2 3.4 2.5 1.0 2.2 2.2 1.3 1.3
0.9 1.3 0.52 YMR219W 0.7 1.1 1.0 0.7 1.6 0.8 1.1 2.3 0.9 1.5 1.5
2.1 0.5 1.7 0.8 1.1 0.9 0.23 YMR275C 0.7 0.7 1.2 0.6 0.7 1.4 0.8
0.8 2.4 2.1 1.1 0.7 2.1 0.8 1.7 1.0 0.9 0.7 0.79 YMR314W 1.2 0.9
1.3 1.3 1.1 1.2 5.9 2.7 1.8 1.0 2.6 1.0 1.2 1.6 1.3 1.6 1.67
YNL006W 1.1 2.1 1.3 1.5 0.9 1.0 1.6 1.1 4.0 4.0 1.1 0.7 2.3 0.8 0.7
0.9 1.0 1.3 1.20 YNL007C 0.7 2.4 5.1 0.8 1.2 0.6 1.2 0.8 3.0 1.7
1.3 0.7 2.1 0.4 0.8 0.5 1.1 1.0 3.62 YNL093W 2.1 6.4 0.4 4.5 1.2
1.6 1.4 0.8 1.7 2.0 1.6 1.1 2.2 1.1 0.6 4.9 3.0 3.1 0.32 YNL333W
1.0 1.4 1.7 2.3 1.5 1.5 2.9 2.1 2.3 2.1 2.0 1.0 2.2 1.9 1.0 1.4 1.4
1.1 0.49 YNR010W 1.3 1.2 0.5 2.8 1.8 1.3 1.5 1.1 1.7 0.9 1.4 0.8
2.8 1.3 0.8 1.2 1.7 2.3 0.37 YNR069C 1.5 1.3 0.7 0.4 1.4 1.7 1.4
1.4 5.5 5.8 2.5 1.2 3.4 2.1 1.0 0.8 1.1 0.9 0.18 YOL164W 0.9 4.4
1.0 1.5 1.6 1.2 2.2 1.0 4.9 3.6 1.0 1.1 3.4 1.3 1.0 1.1 1.1 1.3
0.45 YOR036W 1.8 0.9 1.4 1.6 1.1 1.7 1.8 1.4 1.2 1.9 1.3 1.2 2.1
1.2 1.2 1.3 1.6 1.7 0.98 YOR117W 0.8 1.3 1.7 0.8 1.2 1.1 3.3 1.0
3.5 1.8 1.2 2.5 2.3 1.0 1.4 1.2 1.4 0.9 1.42 YOR124C 0.6 1.1 1.3
0.8 1.1 0.9 1.1 1.3 2.0 1.9 1.2 0.9 2.1 0.8 1.3 0.9 1.0 1.0 0.65
YOR132W 0.9 1.6 0.8 2.8 1.1 1.6 1.4 1.2 2.8 1.6 1.3 0.7 2.5 0.7 1.5
1.6 1.2 1.6 0.46 YOR157C 1.0 1.3 1.2 1.3 0.7 1.2 1.2 1.2 5.7 2.6
1.6 1.3 2.4 2.2 1.9 0.9 1.2 1.2 1.23 YOR185C 1.1 1.3 1.9 1.1 1.2
3.0 1.3 1.4 1.9 2.9 1.2 1.5 2.2 2.1 1.0 2.2 0.9 1.1 1.67 YOR259C
0.8 1.1 0.8 0.9 2.0 0.8 1.3 1.1 2.7 1.5 1.0 0.8 1.8 1.2 1.3 1.4 0.9
1.5 2.33 YOR261C 1.0 1.4 0.6 0.9 1.5 1.4 1.9 2.6 5.5 2.5 2.1 0.9
2.5 1.8 1.3 2.0 1.0 1.9 2.80 YOR288C 0.9 1.3 1.1 1.1 1.1 1.0 2.0
1.9 0.9 1.0 1.4 1.4 2.4 0.8 1.8 1.4
1.5 1.6 0.79 YPL109C 1.1 2.5 0.5 1.2 1.2 1.2 1.8 1.1 1.2 1.5 -0.2
0.9 1.8 1.3 1.3 1.9 1.2 1.2 0.21 YPL149W 1.5 1.5 0.6 2.8 0.8 0.9
1.2 1.1 5.6 3.7 1.2 0.9 2.3 1.0 0.8 1.2 2.2 2.9 1.39 YPL154C 0.7
3.3 4.2 1.2 1.2 3.5 1.5 0.8 2.8 1.7 1.8 1.5 3.1 0.8 4.0 1.8 1.6 2.0
3.78 YPR103W 0.7 1.1 1.3 0.7 1.7 1.2 1.6 1.0 5.5 2.0 0.9 1.2 2.8
1.8 1.0 1.1 1.2 1.5 1.93 YPR108W 0.8 1.0 1.3 0.6 1.3 1.5 1.6 1.6
3.7 2.8 1.8 1.0 2.6 1.0 1.3 1.2 1.0 1.3 2.25 YCL027W 0.7 2.0 1.0
1.0 1.2 1.3 1.0 0.6 0.7 16.3 0.9 0.8 1.1 1.2 3.6 1.1 0.7 0.8 0.30
YDR055W 1.7 2.1 2.2 2.8 1.7 3.9 1.5 1.6 0.8 2.4 2.2 1.4 3.1 0.9 5.7
3.4 2.0 1.9 1.55 YEL042W 0.6 0.9 1.7 0.9 0.7 0.5 0.5 0.7 0.2 0.3
1.6 1.0 0.4 0.6 4.8 0.6 0.7 0.8 1.21 YGR136W 0.9 1.2 1.3 0.7 1.2
1.1 1.5 1.3 2.1 2.2 1.3 1.2 1.7 1.1 2.6 2.2 1.3 1.8 1.42 YHR142W
1.5 0.8 2.1 0.8 1.3 1.2 0.9 1.3 0.4 0.9 1.1 1.3 1.2 1.2 4.8 1.0 1.3
1.3 1.17 YJL073W 0.8 0.8 2.5 0.7 1.2 2.0 1.0 1.7 0.7 0.5 1.0 1.6
1.1 2.6 0.8 1.1 1.0 0.43 YJR004C 0.2 0.8 3.4 0.6 1.1 1.2 0.4 0.4
0.3 0.7 0.7 0.8 0.3 0.7 3.2 0.3 0.4 0.4 2.12 YKL039W 0.8 1.1 2.4
0.8 0.7 4.9 2.0 0.8 1.3 3.3 1.0 0.9 1.9 0.8 3.1 1.5 1.2 1.3 1.13
YLR250W 1.5 1.0 1.0 1.4 1.4 1.1 1.9 1.3 2.7 2.4 1.4 1.0 1.2 2.5 2.6
2.1 1.4 2.2 2.90 YOR181W 1.0 0.9 1.1 1.4 0.7 0.9 0.7 0.7 0.6 0.5
1.0 0.8 1.2 0.9 3.4 1.0 1.1 0.6 0.39 YOR198C 1.0 0.7 1.4 1.0 0.8
0.9 1.6 1.3 2.4 1.4 1.4 1.5 1.8 1.1 3.8 0.8 1.1 1.5 1.76 YPL089C
1.2 1.0 0.5 1.8 1.4 0.8 0.9 0.8 0.4 2.5 0.9 0.7 1.3 0.8 2.6 0.9 1.5
1.1 0.37 YBR214W 0.9 2.1 5.7 2.0 1.1 0.8 1.1 0.7 2.2 3.5 3.2 1.2
2.1 0.9 5.1 1.3 1.1 1.2 0.51 YDR085C 1.9 1.8 1.6 3.4 0.9 2.1 4.1
2.0 0.4 2.3 1.7 1.6 1.1 1.6 3.1 2.3 1.3 1.8 0.37 YDR259C 1.4 1.0
0.4 1.4 1.0 0.5 2.8 1.4 1.0 1.8 1.2 1.0 2.0 1.5 2.9 0.9 1.0 0.8
0.28 YDR388W 0.7 0.7 1.2 1.0 0.7 1.0 1.1 0.8 1.4 0.9 1.6 0.8 1.7
0.6 2.6 1.0 1.2 1.3 0.99 YDR432W 0.5 0.8 1.0 1.4 1.6 0.6 0.5 0.5
0.7 0.8 0.6 0.7 1.4 0.5 2.6 0.6 0.7 0.7 2.38 YDR481C 0.7 2.3 1.3
0.7 1.0 0.9 0.7 1.0 1.9 1.6 1.2 0.9 1.5 0.9 3.5 1.3 1.2 1.4 1.43
YDR510W 1.0 1.3 1.5 1.3 0.7 1.0 1.6 1.5 2.7 2.5 1.6 1.4 2.0 1.9 2.2
1.5 1.1 1.5 1.57 YGR189C 1.1 0.9 1.5 3.5 0.7 0.5 0.6 1.0 0.3 0.9
1.5 1.3 1.2 0.9 9.3 0.6 2.3 1.7 1.51 YIL123W 1.0 0.5 1.2 1.5 0.6
0.5 0.5 0.6 0.1 0.2 1.2 0.8 0.4 0.3 4.8 0.7 1.3 1.0 1.67 YIL140W
0.7 1.0 1.5 1.4 0.8 0.5 0.5 0.7 0.7 0.6 0.9 1.0 0.5 0.9 3.3 0.6 0.7
1.0 0.62 YKL096W 1.4 0.6 8.1 1.6 0.6 0.6 0.2 0.5 0.0 0.5 3.5 0.3
0.1 0.5 2.3 0.4 0.5 0.7 2.04 YLR391W 0.7 2.9 0.8 1.2 1.5 0.7 0.7
0.4 0.7 1.4 1.0 0.9 0.5 3.9 1.3 1.4 0.9 1.72 YMR094W 1.0 0.5 1.3
1.7 0.9 0.5 0.8 1.0 -0.1 0.9 1.0 0.9 1.4 2.8 6.6 1.0 1.0 1.0 0.23
YMR104C 1.9 14.3 2.2 2.6 0.7 1.9 1.5 0.9 0.6 3.2 1.1 1.0 1.5 1.1
2.5 2.3 2.8 1.9 0.51 YMR276W 0.6 1.4 1.5 0.7 1.3 0.8 1.1 0.8 1.8
1.7 1.9 1.2 1.9 1.2 3.3 0.9 1.2 0.7 0.47 YOL013C 0.9 1.0 1.0 1.5
0.7 1.1 1.7 1.0 0.8 1.0 1.4 1.1 1.8 0.9 2.7 1.3 1.1 1.4 0.65
YOR355W 0.7 0.6 1.1 0.8 1.0 1.6 1.1 0.8 0.1 0.8 1.2 0.9 1.1 0.6 3.2
0.8 0.8 0.9 0.98 YCR071C 1.1 0.7 0.9 0.8 1.2 2.5 1.4 0.9 0.6 1.2
1.1 1.1 1.3 1.7 1.1 1.5 1.2 1.3 0.96 YDL008W 1.1 1.0 1.0 1.1 1.8
2.7 2.0 1.2 2.3 3.0 0.9 1.2 2.0 2.2 0.7 1.3 1.5 1.6 0.95 YDR115W
1.3 0.9 0.6 1.5 1.4 2.3 1.6 1.3 1.1 1.0 1.2 0.9 1.1 1.5 0.8 2.2 1.2
1.4 1.50 YER130C 0.9 1.6 0.5 0.8 1.7 2.7 1.5 1.2 0.5 1.3 0.9 1.0
1.6 0.8 1.1 0.7 3.0 2.5 1.36 YMR226C 1.1 1.8 1.4 1.6 0.9 2.6 1.8
1.6 2.6 2.2 1.4 1.1 1.6 1.6 2.0 1.7 1.6 2.0 2.03 YOR383C 0.9 4.3
2.6 0.9 0.9 6.8 8.0 1.0 1.2 4.5 1.4 1.1 1.2 0.6 1.1 3.0 1.4 1.1
0.68 YAR010C 0.8 1.2 1.2 0.8 1.0 2.3 1.9 1.3 1.2 1.1 0.9 1.0 1.4
1.0 1.8 0.7 1.5 1.0 4.69 YBL043W 1.2 1.2 1.1 1.3 1.1 26.9 1.5 2.1
0.5 14.7 1.5 0.9 1.8 1.9 1.8 2.3 2.3 1.8 0.47 YCR004C 1.7 1.0 12.0
1.2 1.8 1.4 1.2 4.7 2.1 1.9 0.8 1.3 3.7 0.8 4.9 1.4 3.5 3.02
YCR088W 0.9 1.1 1.2 0.9 1.1 2.0 1.2 0.5 0.8 0.9 1.0 1.3 1.9 0.9 2.8
0.7 1.4 0.9 0.47 YDL238C 0.7 1.0 1.1 1.7 0.9 2.1 1.4 5.8 1.7 2.7
1.1 0.9 2.0 1.2 1.3 1.7 1.1 1.3 0.35 YDR084C 0.9 0.9 1.5 1.1 1.2
2.1 0.9 0.7 0.6 0.6 0.7 0.7 1.0 1.0 3.9 1.0 2.0 1.3 1.12 YDR104C
0.8 1.1 1.2 1.2 1.3 1.7 1.0 1.3 2.8 2.7 1.0 1.1 1.6 1.4 1.4 0.9 0.9
1.0 0.34 YDR315C 1.0 1.4 1.0 1.3 0.9 9.4 1.4 1.4 1.1 1.6 1.1 0.6
1.6 1.4 1.5 1.5 1.2 1.2 0.48 YDR358W 0.7 1.1 0.7 1.1 1.4 2.5 2.8
1.2 2.9 3.2 1.0 1.1 3.2 1.2 0.9 2.2 1.9 1.9 0.50 YEL066W 2.0 2.9
1.5 2.2 0.8 2.2 1.8 1.4 1.3 2.4 1.9 0.8 1.6 1.9 1.0 1.9 1.0 1.1
0.64 YER039C 1.0 1.2 1.0 4.1 1.5 1.6 1.3 0.7 1.2 0.8 1.2 0.9 2.1
1.2 1.2 1.8 1.7 1.1 0.42 YER107C 0.9 0.5 1.0 0.6 1.3 2.5 1.0 0.8
0.4 0.5 0.7 0.7 0.9 1.1 0.7 0.9 1.1 1.2 0.92 YFL028C 1.2 1.1 0.7
1.5 1.7 1.7 2.0 1.5 2.7 1.8 1.3 1.1 1.4 1.6 0.8 1.9 1.2 1.5 1.28
YFL043C 1.0 1.2 0.6 1.2 1.2 1.8 1.8 1.0 2.2 3.8 1.1 0.9 1.5 1.5 1.1
2.0 1.5 1.2 0.38 YGL229C 0.6 0.7 0.9 0.8 1.0 2.2 2.2 0.7 1.8 1.7
1.1 1.1 1.7 1.0 0.2 1.8 1.1 0.9 0.44 YGR257C 0.7 0.8 0.9 1.1 1.3
2.1 2.4 1.0 1.5 1.9 1.2 0.9 2.0 0.9 1.3 1.3 1.1 1.3 0.84 YHR004C
0.9 1.1 0.8 1.1 1.5 2.0 1.5 0.9 1.1 0.6 0.8 0.9 1.1 0.8 1.2 2.4 1.4
1.6 0.84 YHR071W 1.5 1.1 0.6 1.6 1.5 2.0 1.0 1.7 1.0 7.2 1.8 0.8
2.3 1.6 3.0 1.7 2.6 1.0 0.79 YJL089W 1.1 1.5 1.0 0.8 1.1 1.6 1.1
1.1 1.6 3.9 0.6 1.2 1.8 1.8 6.4 1.2 1.2 1.1 0.21 YJL116C 0.9 1.8
1.3 1.9 1.3 3.4 0.8 1.8 2.4 2.6 2.9 1.1 4.3 2.6 1.0 1.3 1.2 0.7
1.01 YJR086W 1.2 1.1 0.8 1.4 1.3 1.9 1.7 1.1 1.4 1.1 1.0 0.8 0.9
2.2 2.0 1.4 1.4 1.6 1.24 YKL008C 1.2 0.6 2.0 0.8 0.9 3.8 1.4 1.2
0.3 0.4 1.5 1.5 1.7 0.8 1.3 2.1 1.4 1.9 2.11 YKL013C 1.4 0.9 1.4
1.1 1.9 1.9 1.8 0.9 1.5 1.4 1.1 0.7 1.3 1.4 1.2 1.5 1.6 1.7 1.55
YKL041W 1.2 0.8 1.1 1.0 1.3 2.2 1.0 1.6 1.6 1.5 1.2 0.8 1.3 1.3 1.0
2.5 1.1 1.3 0.91 YKL139W 0.9 0.7 1.4 0.8 2.8 3.5 2.6 1.2 1.6 1.5
1.4 0.8 1.6 1.0 1.0 1.3 1.9 0.8 0.62 YKR014C 1.1 1.3 0.7 1.1 1.5
2.1 1.7 1.6 2.4 2.0 1.1 1.1 1.5 1.8 1.4 2.4 1.0 1.7 2.05 YLR093C
1.3 0.8 0.7 1.2 1.4 2.9 1.9 1.2 1.5 1.3 1.0 1.0 1.3 1.3 0.9 2.4 1.7
3.2 1.90 YLR118C 1.0 1.1 1.6 1.0 1.0 2.5 1.5 1.0 1.1 1.3 1.2 1.0
1.4 1.5 0.8 3.5 1.3 1.9 1.17 YLR251W 1.8 0.8 4.2 4.6 1.6 2.1 2.6
1.2 2.1 1.3 4.1 0.8 1.7 1.3 0.8 2.5 2.1 3.8 0.78 YMR027W 0.8 2.6
0.7 0.8 1.1 2.1 2.0 0.9 1.1 1.4 1.1 0.9 2.4 0.9 4.0 0.8 1.3 1.2
4.05 YMR262W 1.0 1.3 1.9 1.1 1.2 2.0 1.9 1.0 3.0 1.2 1.3 0.8 1.7
0.9 0.3 1.0 1.0 1.2 0.65 YNL214W 1.2 0.9 1.1 1.1 1.4 2.3 1.3 1.1
1.5 1.5 0.6 0.8 1.2 1.7 0.9 2.0 1.1 1.2 0.47 YOR149C 0.7 0.9 1.0
0.8 1.1 2.3 1.0 0.7 0.4 1.0 1.0 0.9 1.3 0.9 1.3 1.1 1.0 1.2 0.76
YOR165W 0.9 1.5 0.7 0.8 0.8 2.2 0.9 1.1 0.8 1.3 1.3 0.7 0.9 0.8 0.8
1.0 0.9 1.0 1.03 YOR285W 1.4 6.0 3.5 1.9 1.7 2.1 4.0 1.2 4.0 2.9
2.3 0.9 2.1 1.6 2.0 2.9 2.3 3.3 2.62 YOR367W 1.0 0.9 1.7 0.9 1.1
3.3 1.9 1.1 1.1 1.1 1.4 0.5 0.8 1.5 1.1 1.3 1.4 1.4 0.60 YPL018W
1.0 1.4 1.0 0.5 1.8 2.1 0.9 1.1 1.4 1.2 1.3 1.1 2.2 1.3 0.9 0.8 1.3
0.8 0.22 YPL203W 1.3 1.0 2.2 1.0 2.1 1.8 2.1 1.1 1.8 2.1 1.5 0.9
1.5 1.0 0.6 2.3 1.3 1.7 0.79 YPL255W 0.8 0.3 1.1 0.6 0.9 2.0 0.6
0.9 0.1 0.1 0.7 0.6 0.6 0.7 0.6 0.7 0.8 0.7 0.55 YPR073C 1.2 1.9
0.5 1.4 1.8 2.0 2.5 1.5 1.3 2.6 0.9 0.8 1.4 1.5 0.8 1.8 1.4 1.8
1.55 YDR518W 0.8 1.7 1.1 1.2 1.6 1.2 2.7 1.1 0.2 1.2 1.0 1.5 1.8
0.8 2.5 1.7 1.4 1.6 0.93 YOR381W 0.8 2.0 0.8 1.8 1.0 1.0 3.6 0.8
1.2 3.5 2.6 1.1 1.7 0.8 0.6 2.5 0.8 0.9 0.38 YBR109C 1.6 1.3 2.4
1.1 1.0 1.4 2.4 1.7 3.8 3.3 1.5 1.4 2.0 2.0 1.4 1.9 1.4 1.9 2.15
YBR201W 1.2 4.3 1.2 2.4 1.2 1.0 3.4 2.2 0.8 1.0 1.1 1.7 1.9 1.1 1.6
1.5 1.8 1.6 0.75 YDR041W 1.2 1.1 0.6 1.8 2.0 1.6 2.4 1.2 1.3 1.3
1.2 0.8 0.9 1.4 1.0 2.4 1.5 2.5 1.85 YER136W 0.9 1.1 1.1 1.4 1.6
1.3 2.1 1.3 1.4 1.6 1.7 0.9 1.3 0.8 1.2 1.6 1.3 1.7 2.31 YER159C
1.1 0.9 0.2 1.6 2.1 1.3 2.0 1.4 0.2 0.9 1.6 0.9 0.9 1.1 2.2 1.1 1.6
1.9 0.99 YJL030W 1.6 1.4 0.5 1.0 1.3 1.1 1.9 1.6 2.3 1.9 1.4 1.0
1.4 2.1 1.5 1.9 1.3 1.5 0.87 YJR029W 0.8 1.3 0.6 0.8 1.0 2.4 0.9
1.1 1.5 0.6 1.0 2.1 1.1 1.8 0.7 0.8 1.1 5.84 YJR099W 1.4 0.9 1.1
1.3 1.5 2.1 2.0 1.4 1.4 2.4 1.3 0.7 1.5 2.1 0.5 2.0 1.1 1.7 0.94
YJR122W 2.0 1.4 2.5 1.1 1.3 1.4 1.8 1.4 5.3 6.1 2.4 0.9 1.3 1.4 0.8
1.9 1.0 1.1 0.43 YJR125C 1.0 1.0 1.2 1.0 1.2 1.3 1.9 0.9 1.8 1.3
1.1 0.9 1.5 1.1 1.3 2.0 1.2 1.4 0.90 YKL190W 1.1 1.3 0.4 0.9 1.5
2.0 1.1 1.8 1.9 1.5 0.9 1.3 1.7 1.4 1.8 1.3 1.3 1.14 YLL051C 0.8
1.1 1.0 1.5 1.4 1.2 2.0 0.9 0.9 1.8 0.7 1.1 1.3 0.8 1.2 0.8 1.0 1.0
0.81 YLR090W 0.7 1.1 0.8 1.3 1.2 1.3 2.2 0.9 1.8 1.4 1.0 0.8 1.7
1.0 0.8 1.9 0.8 1.0 0.67 YMR051C 0.9 2.8 0.8 1.3 1.7 1.2 2.6 0.9
1.0 1.4 1.1 0.9 1.3 1.2 1.7 1.0 1.8 1.2 3.91 YMR139W 1.0 3.4 2.5
1.5 1.2 1.5 2.2 0.9 2.8 2.4 1.3 0.9 1.6 1.3 0.9 2.3 1.1 2.0 0.89
YNL015W 2.3 6.7 1.8 2.4 1.8 1.7 3.5 2.2 2.1 4.3 2.1 2.8 3.9 1.6 1.4
5.3 3.0 5.2 1.03 YNL079C 1.1 1.0 0.4 1.0 1.7 1.1 1.9 1.6 1.5 1.2
1.3 1.2 1.8 1.0 1.5 1.4 1.0 1.9 3.26 YNL223W 1.1 1.2 0.6 1.7 1.0
1.8 2.2 1.4 3.3 1.9 1.3 1.3 2.0 1.2 1.0 2.1 1.0 1.5 0.34 YNR007C
1.2 1.8 0.7 1.0 1.5 1.3 1.9 1.2 2.5 2.0 0.7 0.9 1.5 1.5 0.6 2.0 1.4
1.6 0.49 YNR035C 0.8 1.2 1.7 1.0 0.8 1.1 2.6 1.1 2.9 1.5 1.5 1.1
1.7 1.0 1.3 1.6 1.4 1.8 1.60 YOL016C 1.3 2.0 0.4 2.0 1.6 0.9 3.0
1.3 1.9 1.6 1.3 1.4 3.0 0.7 0.5 1.6 4.3 3.8 2.10 YOL104C 1.0 1.7
0.2 1.8 1.9 1.4 2.6 1.4 0.2 1.7 1.2 0.8 0.6 2.2 1.3 0.5 1.1 0.9
0.32 YPR107C 1.4 1.0 1.2 1.9 1.5 1.3 2.0 1.3 2.4 2.4 1.2 0.7 1.4
1.7 1.0 1.4 1.2 1.5 0.81 YOL152W 0.2 0.6 1.0 0.8 0.7 1.8 2.4 4.1
0.9 1.2 5.9 0.8 0.5 0.4 0.8 1.2 1.1 1.2 0.91 YAL007C 1.3 0.9 0.9
1.5 0.6 0.7 1.5 1.7 1.1 0.9 2.0 1.3 2.0 1.3 2.5 0.8 1.2 1.5 1.74
YDL043C 1.0 0.8 0.8 1.2 1.1 0.5 0.9 1.3 0.8 0.8 3.9 0.9 0.8 1.2 0.8
1.2 0.8 0.8 0.78 YDL212W 1.0 1.2 1.6 1.2 1.1 0.4 0.7 0.9 0.4 0.6
2.0 0.8 0.5 1.0 1.1 0.9 1.1 1.7 4.27 YDR183W 1.2 0.7 0.9 1.4 1.5
1.4 1.8 1.8 2.5 2.9 1.8 1.1 1.4 1.9 1.4 1.3 0.8 1.0 0.61 YGL089C
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0.6 3.00 YGL096W 1.9 2.9 1.2 2.5 0.9 0.5 1.8 1.7 2.1 3.6 1.7 1.1
1.2 1.4 0.8 1.7 1.1 1.1 0.54 YGR006W 1.2 1.1 0.9 2.9 0.5 0.5 1.0
1.2 0.7 0.9 1.6 0.8 1.4 1.1 1.2 1.5 0.9 1.0 0.40 YHL034C 0.7 1.0
0.7 0.8 1.9 1.1 1.4 1.4 1.9 1.9 2.2 0.8 1.6 1.0 1.4 1.6 1.2 1.5
2.11 YHR163W 0.9 1.2 1.3 1.2 0.8 1.9 0.9 1.3 1.4 1.1 2.9 0.7 1.1
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5.6 2.9 6.3 1.1 1.6 2.6 0.9 2.2 0.9 1.4 0.75 YKL070W 1.0 0.8 1.7
0.9 1.3 1.1 1.1 1.5 15.0 11.0 10.4 0.6 1.0 2.2 0.8 0.9 1.0 0.9 0.29
YLL050C 1.4 1.0 1.2 1.7 1.9 1.4 1.3 1.0 1.0 2.3 0.9 1.8 1.2 1.6 1.3
1.2 2.1 3.43 YLR220W 0.9 0.6 3.0 1.0 0.9 0.3 0.4 1.0 0.4 0.4 2.4
0.7 0.5 1.4 0.7 1.1 0.8 0.8 2.28 YLR390W 0.9 0.9 1.2 1.7 1.2 0.7
1.5 0.8 1.7 1.7 1.9 1.0 1.1 1.1 0.5 2.0 1.0 0.9 0.51 YOL044W 1.0
1.4 1.0 1.3 1.0 1.2 1.2 1.1 1.6 1.4 2.1 0.7 1.3 1.1 0.6 1.3 1.6 1.9
0.65 YOL147C 1.6 1.1 2.4 1.5 0.7 0.9 0.6 1.5 0.5 0.7 2.8 0.7 0.8
0.9 0.8 2.4 2.0 1.7 1.09 YDR069C 1.4 0.8 3.0 1.5 1.6 0.7 1.0 1.8
1.8 4.5 0.8 0.7 1.3 1.2 1.0 1.3 1.0 1.3 0.33 YER131W 1.5 0.3 0.9
0.7 1.6 0.9 0.6 2.0 0.0 0.6 1.0 0.9 0.2 0.8 0.9 0.4 0.9 0.9 5.32
YGR044C 0.8 1.3 0.7 1.2 1.1 1.4 1.3 1.8 0.9 0.8 2.1 0.8 1.4 1.0 0.5
3.3 1.1 2.6 1.43
YMR240C 1.1 0.6 2.5 0.7 1.4 0.8 1.1 2.3 0.5 1.1 1.4 0.6 0.8 1.1 1.0
1.0 1.1 1.1 0.39 YBR105C 1.7 1.5 0.9 2.0 0.8 1.8 2.0 1.2 1.1 3.3
1.1 1.2 1.1 1.7 1.4 1.3 1.3 1.1 0.96 YBR182C 2.0 1.9 1.0 2.4 1.4
1.0 1.7 1.3 0.6 3.2 1.5 1.3 1.2 1.2 3.1 1.1 3.4 1.6 0.41 YBR186W
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1.0 0.31 YEL052W 1.1 1.0 2.0 2.0 1.3 1.2 1.2 1.2 3.0 3.4 1.7 1.1
1.5 1.1 0.7 2.1 0.9 1.0 0.90 YER098W 0.9 0.9 0.5 1.1 1.4 1.6 1.3
1.7 2.8 3.3 1.4 1.0 1.1 1.3 0.9 1.7 1.2 1.5 0.35 YGL240W 0.9 1.2
0.8 1.8 1.2 1.1 1.2 0.8 2.0 3.4 0.9 0.8 1.7 1.3 1.1 1.0 1.2 0.8
0.48 YGR067C 2.2 1.4 1.2 4.6 1.6 1.3 1.5 1.5 0.7 6.7 1.0 0.7 1.0
0.9 1.2 1.7 1.2 1.0 0.11 YGR133W 1.0 1.1 0.7 0.6 1.3 1.2 1.2 1.2
1.3 3.6 1.6 0.9 1.2 1.4 1.0 1.5 1.0 1.0 0.35 YHR124W 1.1 1.1 1.5
2.0 0.9 0.8 1.2 1.1 3.0 6.8 1.1 1.2 1.7 2.7 0.8 1.8 1.3 1.1 0.24
YJL103C 1.3 1.8 3.8 1.3 1.1 1.0 0.7 0.8 2.3 2.4 1.5 0.8 1.4 1.0 1.3
0.9 1.4 1.2 0.44 YJR036C 1.2 1.2 1.0 4.3 1.5 0.9 1.0 1.0 1.4 3.0
1.1 0.9 1.1 1.3 1.8 2.0 0.9 1.2 0.31 YLR216C 1.2 2.3 3.3 1.1 1.2
1.2 5.2 1.3 14.1 4.1 1.8 0.7 1.2 1.1 1.2 1.5 1.2 1.3 1.44 YLR389C
0.8 6.4 2.3 0.6 0.7 0.2 1.0 1.0 2.4 2.8 0.9 0.8 1.9 0.8 1.0 1.4 1.0
1.0 0.60 YNL128W 1.3 4.6 1.1 0.8 1.2 1.1 1.0 1.3 2.9 2.4 0.9 0.9
1.4 1.4 1.1 0.6 0.9 0.9 0.21 YOL133W 1.0 1.6 1.4 1.2 0.9 1.6 1.8
1.0 4.7 3.8 1.5 0.6 1.0 1.4 1.3 2.0 1.3 1.3 0.87 YOR133W 1.1 1.3
1.6 1.3 1.3 0.9 1.1 0.8 3.1 4.9 1.3 0.8 1.3 1.1 1.8 1.3 1.2 1.2
0.26 YOR227W 1.1 2.4 3.2 0.9 0.5 1.0 1.0 0.7 2.9 3.0 1.2 1.0 1.7
1.1 3.7 2.2 0.8 1.3 0.35 YPR015C 1.3 1.3 1.5 1.7 1.1 0.7 1.3 1.2
5.6 5.3 1.0 0.7 1.5 1.5 1.6 2.0 1.0 1.0 0.32 YPR086W 1.0 1.4 0.7
0.7 1.2 1.1 1.6 1.3 3.0 2.9 1.3 0.8 1.0 1.0 1.3 1.4 1.2 1.2 1.37
YBL056W 0.7 0.7 1.1 1.2 1.8 1.6 1.4 1.3 3.6 2.2 0.7 0.9 2.7 0.9 1.0
1.7 1.1 1.5 2.49 YBR026C 1.1 1.7 2.8 0.9 1.2 0.1 1.1 3.4 1.6 1.6
1.2 1.5 1.5 0.7 0.5 0.8 0.9 0.59 YBR123C 0.8 0.7 1.6 1.8 1.1 1.3
0.9 0.9 3.2 2.5 1.1 1.0 1.4 1.1 1.0 1.2 0.8 1.0 0.62 YDR099W 0.9
1.0 2.0 1.3 1.1 2.2 1.3 1.1 2.4 1.3 1.1 0.9 1.5 0.9 1.9 1.4 1.2 1.7
3.51 YDR177W 1.2 1.7 1.0 1.0 1.0 1.4 1.3 1.6 3.5 1.9 1.3 1.2 1.7
2.4 0.8 1.3 1.3 1.5 1.77 YDR392W 0.9 2.9 1.1 1.3 1.2 0.6 1.1 1.1
4.3 1.5 1.2 0.8 1.4 1.3 1.1 1.4 1.0 1.2 0.63 YDR394W 0.9 1.2 1.3
0.8 1.2 1.1 1.2 1.3 3.8 2.0 1.8 0.6 1.0 1.2 1.1 1.0 1.1 0.8 0.97
YER184C 2.3 1.6 1.1 2.3 1.0 0.6 0.9 1.1 4.6 3.2 1.3 0.8 1.6 1.4 1.4
1.2 1.6 2.3 0.29 YFL059W 1.2 1.4 1.2 2.2 1.1 1.0 1.3 1.5 4.1 4.2
1.5 1.2 2.3 2.4 0.9 1.6 1.3 1.1 0.57 YGL185C 1.3 1.9 1.9 1.9 0.8
0.8 1.9 1.5 4.1 2.3 1.5 1.5 1.7 1.5 0.9 15.8 1.3 1.6 0.23 YHL019C
1.1 0.8 1.2 0.6 1.0 1.2 1.1 1.0 2.1 1.4 1.3 0.8 0.8 0.8 1.2 1.3 1.0
1.0 0.55 YHR012W 1.1 1.0 1.2 1.0 1.6 1.2 1.2 4.9 2.2 1.5 0.9 1.7
1.7 1.0 1.0 1.2 1.4 1.11 YHR028C 0.8 1.2 1.4 0.8 1.0 0.9 1.2 0.8
3.7 2.2 1.4 0.7 0.6 1.1 1.1 0.7 1.0 1.0 0.92 YHR109W 0.8 1.0 0.0
0.7 1.3 1.4 1.4 1.2 2.4 1.8 0.7 1.0 1.4 1.5 0.9 1.3 0.9 1.1 0.22
YHR156C 1.3 1.3 0.9 2.1 1.9 1.0 1.2 1.2 3.6 1.9 0.6 0.7 1.0 1.9 1.2
1.4 0.9 1.3 0.47 YIL159W 1.1 1.6 1.3 0.7 1.2 2.3 0.6 1.1 5.9 1.6
0.8 0.9 1.5 2.0 1.0 0.7 0.9 0.8 0.29 YJL154C 0.6 2.7 0.7 0.6 1.2
1.3 1.5 1.0 2.3 2.0 0.5 0.9 1.6 0.8 1.2 1.2 1.2 1.1 0.62 YJR110W
1.0 0.6 1.0 1.4 1.3 0.9 0.9 1.1 4.9 2.3 1.2 0.7 0.9 1.1 1.2 1.1 0.8
1.0 0.58 YKL025C 0.7 1.1 1.1 0.9 1.1 0.9 0.9 0.9 2.8 1.7 1.1 0.8
1.3 0.9 1.2 1.1 0.9 1.0 0.54 YKL171W 0.9 1.3 1.2 2.1 0.9 0.4 0.9
0.8 8.2 1.8 2.8 1.1 1.5 1.1 1.2 2.1 0.9 1.2 0.45 YKL196C 1.2 1.1
0.5 0.9 1.3 0.9 1.5 1.3 4.3 2.0 1.6 1.0 1.8 2.5 1.9 1.9 1.3 2.0
2.41 YKR068C 1.2 1.5 1.0 1.8 1.1 1.4 1.4 1.3 2.4 1.9 1.0 1.0 1.1
1.6 0.8 1.4 1.4 1.7 1.72 YLR144C 0.8 1.5 4.0 1.3 0.7 0.9 0.7 1.1
2.8 1.5 1.0 0.7 2.3 1.2 1.9 1.7 1.0 1.0 0.44 YML112W 1.0 1.0 1.1
2.0 1.0 1.4 0.9 1.3 3.2 2.4 1.0 1.0 1.3 1.8 0.8 0.9 0.8 0.9 0.49
YOL038W 0.9 1.0 0.4 1.6 1.8 1.2 1.4 1.4 3.5 2.7 2.0 0.9 1.8 2.1 1.7
1.6 1.1 1.4 1.29 YOR257W 1.1 2.5 0.8 1.1 1.1 0.8 1.3 1.5 3.4 1.4
1.0 0.7 0.8 1.5 0.7 1.6 1.1 1.6 0.68 YOR265W 1.4 1.0 0.8 1.0 1.2
1.4 1.3 1.4 3.5 2.2 1.3 0.8 1.8 2.5 1.2 1.1 1.0 1.2 0.93 YPL124W
1.3 1.3 0.7 0.7 1.6 0.8 0.9 1.8 2.2 1.0 0.9 0.7 0.9 1.6 0.6 0.8 1.3
1.2 0.41 YPR125W 0.6 1.3 0.9 1.2 0.7 1.3 1.2 4.1 1.8 0.9 1.1 1.9
1.6 2.0 0.6 0.8 0.7 0.73 YPR168W 0.9 1.0 0.2 0.5 1.3 0.4 1.1 1.1
4.7 2.7 1.2 0.5 1.0 1.1 1.2 1.3 0.9 0.8 0.29 YPR180W 0.9 1.2 1.6
1.0 1.0 0.8 2.4 1.3 2.3 1.1 0.5 0.7 1.3 1.2 1.3 1.0 1.0 1.4 0.61
YPR193C 1.0 2.2 0.6 1.1 1.4 1.3 1.4 1.1 3.5 4.1 0.1 0.9 1.6 1.6 0.9
1.6 1.1 0.9 0.17 YBR045C 0.9 1.0 2.2 0.7 1.0 0.8 0.8 1.0 3.6 1.1
0.4 1.3 1.3 1.0 2.0 0.8 1.1 0.9 1.29 YBR128C 1.0 1.1 2.1 1.0 1.1
1.5 2.1 1.2 2.8 1.2 1.3 0.7 1.3 1.4 1.4 2.0 1.2 1.8 0.44 YCL055W
0.7 2.2 0.7 1.3 1.2 1.4 1.0 1.3 2.1 1.5 1.4 0.9 0.9 1.8 1.5 0.7 0.8
1.1 0.66 YCR019W 1.0 1.6 1.0 0.8 1.4 1.5 1.1 1.5 2.8 1.6 2.0 1.0
1.6 1.2 0.7 1.4 1.0 1.0 0.45 YDL065C 1.2 0.9 1.0 0.7 1.4 1.1 1.3
1.4 2.4 1.5 1.4 0.6 0.7 1.4 1.3 1.5 1.1 1.2 1.08 YDL143W 0.8 0.8
1.2 1.1 1.0 1.0 0.9 1.2 2.1 1.8 1.3 1.1 1.9 0.9 1.4 0.9 0.8 0.8
1.86 YDL197C 1.0 1.1 0.9 2.1 1.5 1.2 1.0 1.0 2.6 1.5 1.1 0.8 1.4
1.1 1.3 0.9 1.3 0.8 0.31 YDL230W 1.0 0.8 1.2 1.3 1.4 0.9 1.1 0.9
2.6 1.2 0.9 0.6 1.3 1.0 1.4 1.7 1.0 1.2 0.42 YDR212W 0.8 1.2 1.3
0.8 1.4 1.4 1.0 1.3 3.5 1.7 1.8 0.8 2.0 1.0 1.2 0.7 0.6 1.0 2.13
YDR257C 0.8 5.3 0.6 0.8 1.6 1.1 1.0 1.0 3.0 1.6 1.3 0.7 1.0 1.0 1.3
1.0 1.1 0.8 0.62 YDR329C 0.9 0.8 1.0 1.7 1.9 1.2 1.6 1.2 2.5 1.0
1.0 0.8 1.1 1.1 1.0 1.6 1.2 1.6 0.95 YDR488C 1.0 0.3 0.9 0.9 0.9
0.9 0.7 0.9 2.1 0.4 0.4 0.6 1.3 0.8 3.5 0.7 0.9 0.9 0.32 YDR505C
0.8 1.0 1.0 1.4 1.2 1.1 1.2 0.8 2.5 1.0 1.0 0.7 1.6 0.9 1.1 1.6 1.0
1.5 0.84 YDR506C 0.9 0.7 1.3 0.7 0.9 0.9 0.6 1.0 1.9 1.4 1.1 0.9
0.3 0.5 0.9 0.4 0.6 0.5 1.90 YDR515W 0.9 1.1 0.8 0.8 1.5 0.8 0.6
1.4 5.8 2.7 1.0 0.8 0.7 0.8 1.3 0.5 0.7 0.5 1.02 YEL005C 1.1 1.3
0.8 1.1 1.6 1.9 2.0 1.2 2.3 1.6 1.6 0.8 1.2 1.7 0.8 3.4 1.1 1.4
0.45 YER048C 0.8 1.2 0.4 1.4 1.8 1.9 1.9 1.6 2.3 1.1 1.6 0.8 1.1
1.0 0.6 1.8 1.3 1.6 1.08 YER078C 0.9 0.8 1.8 0.8 0.9 1.4 1.3 1.1
2.3 1.5 1.3 1.0 1.5 1.0 0.9 1.0 0.9 0.9 0.49 YER089C 0.5 0.5 1.4
1.1 0.8 0.6 0.9 0.5 2.0 2.3 1.2 0.7 1.3 0.6 1.0 0.8 0.7 0.6 0.75
YER100W 1.1 1.1 0.7 0.7 0.9 0.5 0.6 1.2 2.3 1.6 1.1 0.8 0.7 0.8 1.0
1.1 1.1 0.7 0.95 YFR051C 0.5 1.1 2.2 0.5 0.5 0.2 1.0 0.8 2.5 1.4
1.3 1.2 1.5 0.8 3.0 0.8 1.1 0.9 0.53 YGL093W 0.8 0.9 1.2 0.6 0.9
1.0 0.8 0.8 4.5 1.6 1.1 0.6 0.7 0.8 1.4 1.0 0.9 1.2 0.56 YGL105W
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0.9 3.01 YGL166W 1.0 1.4 0.6 1.5 1.3 1.0 1.5 1.2 1.8 2.4 1.0 1.1
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0.7 2.2 1.8 0.8 0.7 1.0 0.8 1.0 1.2 0.7 0.9 1.31 YGL216W 0.7 1.3
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0.37 YGL221C 1.1 1.2 1.0 1.1 0.9 2.2 1.3 1.6 3.4 1.9 1.4 1.1 1.7
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0.8 0.7 0.9 0.9 0.9 2.3 1.3 0.7 0.8 1.3 0.9 1.6 1.0 0.9 0.9 0.51
YGR274C 0.7 0.5 0.3 0.9 1.8 0.7 1.3 1.2 2.2 1.8 0.9 0.7 1.1 0.8 1.2
0.7 1.1 1.0 0.62 YHR082C 0.7 1.1 1.6 0.9 1.6 0.8 1.1 0.8 2.6 1.7
0.9 0.7 1.7 0.9 1.4 0.7 1.1 0.9 0.60 YHR160C 1.0 0.5 1.6 1.6 1.0
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1.5 0.41 YHR205W 0.7 1.3 0.6 0.8 1.3 1.0 0.7 0.5 2.0 0.6 0.9 0.9
1.7 0.9 1.5 0.8 0.9 0.8 0.34 YIL062C 1.1 1.0 1.3 1.2 1.2 0.9 0.4
1.1 2.8 2.3 1.7 0.8 1.1 2.0 0.9 0.4 1.1 1.1 1.72 YIL075C 0.5 0.7
1.5 0.6 1.1 0.8 0.8 0.7 1.9 2.3 0.8 0.8 0.7 0.8 1.6 0.8 0.8 0.8
1.54 YIR009W 0.8 0.8 0.9 2.8 1.5 1.4 1.3 1.3 2.6 1.5 1.1 0.7 0.8
1.6 1.1 1.0 1.7 1.0 0.48 YIR018W 1.2 1.0 0.9 1.1 1.4 2.0 1.5 1.5
4.0 2.1 1.2 1.1 1.5 1.2 1.5 1.0 1.6 1.1 0.44 YJR091C 0.8 1.2 2.6
1.4 1.4 0.8 1.1 0.8 2.4 2.3 1.8 0.8 1.4 0.8 1.4 0.7 1.2 0.9 0.57
YKL079W 0.9 0.8 1.5 1.0 1.4 0.8 1.7 1.2 2.3 2.0 1.3 0.9 1.2 0.9 1.1
1.6 1.1 1.2 0.64 YKR102W 0.8 1.6 1.4 0.8 0.9 0.7 2.4 1.4 3.3 0.8
2.7 1.8 1.1 1.5 1.5 0.9 0.19 YLL054C 1.2 0.6 0.5 1.2 1.4 1.9 1.1
1.1 2.4 1.4 0.5 0.7 1.7 1.2 0.9 0.9 1.0 1.0 0.33 YLR200W 1.4 0.9
0.5 1.2 1.7 1.2 1.9 1.4 2.2 2.6 1.1 0.9 1.3 2.3 0.9 1.2 1.1 1.5
1.12 YLR248W 0.9 0.7 1.1 1.4 1.9 1.2 1.2 1.1 2.3 1.1 1.0 0.7 1.2
0.9 1.2 1.7 1.1 1.7 1.58 YLR266C 0.9 1.3 0.7 1.5 0.7 1.0 1.6 1.1
2.2 2.6 1.1 1.0 1.3 1.0 0.8 1.7 0.8 1.4 0.74 YML088W 0.9 1.6 0.3
0.5 1.5 0.7 1.1 1.1 4.0 2.2 0.5 1.0 1.3 1.1 1.4 0.8 0.8 0.8 0.58
YMR091C 1.0 0.7 0.8 1.0 0.7 0.8 0.8 1.3 2.1 1.3 0.9 0.8 0.9 1.5 0.9
1.3 0.9 1.2 1.03 YMR110C 1.0 1.4 1.8 1.9 1.3 2.1 1.9 0.9 2.3 1.6
1.6 0.9 1.8 0.8 0.9 2.7 1.5 2.5 1.63 YMR255W 1.2 1.4 0.7 1.8 1.3
0.9 1.5 1.4 2.8 2.4 1.2 0.9 1.1 1.6 1.0 1.3 1.5 2.0 0.97 YNL039W
0.7 0.8 0.3 0.4 2.1 0.8 1.1 1.2 2.1 1.8 0.4 0.9 0.8 0.8 1.3 1.3 0.9
1.1 0.61 YNL077W 1.5 1.1 2.3 1.2 1.5 0.9 1.2 1.0 4.4 5.1 1.0 0.7
1.5 0.5 0.3 0.6 1.3 1.0 0.78 YNL083W 0.8 1.4 1.3 1.2 0.8 0.7 0.9
1.1 3.1 1.6 0.9 0.9 1.2 0.9 0.8 1.8 0.8 1.1 0.37 YNL147W 1.3 2.4
0.6 0.7 2.0 1.5 1.4 1.8 2.1 2.9 1.2 0.8 1.0 2.0 1.2 1.7 1.0 1.6
1.32 YNR006W 1.1 1.8 0.5 0.9 1.5 0.9 1.5 0.9 2.2 2.3 0.8 0.9 1.6
0.9 1.2 1.1 1.8 1.2 0.40 YNR034W 0.9 1.4 5.3 1.6 1.0 0.9 1.3 1.0
3.0 2.1 1.3 0.9 1.4 0.9 1.1 2.3 0.7 1.1 0.64 YNR047W 0.7 1.0 1.7
0.5 1.1 1.0 1.0 0.8 2.0 1.2 0.6 0.9 1.5 0.9 1.2 1.5 0.9 1.0 0.44
YOR023C 0.7 1.2 1.3 0.8 1.2 1.8 1.1 0.6 3.5 1.3 0.9 1.1 1.9 0.9 1.6
0.8 1.1 0.8 0.37 YOR058C 2.0 1.4 2.0 0.6 0.9 0.9 0.8 1.7 6.4 4.5
1.4 0.7 1.7 1.7 1.1 1.6 0.9 1.0 0.31 YOR069W 0.8 1.6 0.7 1.3 1.0
0.5 1.2 1.1 1.9 1.4 2.8 0.9 1.1 1.3 1.4 1.5 0.8 1.1 0.69 YOR229W
0.9 0.9 1.0 0.8 1.5 1.3 1.1 0.8 2.5 0.8 0.7 0.8 1.3 1.0 1.2 0.9 0.9
1.0 0.58 YOR256C 1.0 0.8 0.9 1.5 1.7 0.9 1.4 1.1 2.7 1.8 1.7 0.7
1.6 1.1 1.1 1.5 1.2 1.5 0.53 YPL020C 1.1 0.7 0.7 1.3 0.8 0.8 1.1
1.1 2.3 1.6 1.1 0.9 1.1 1.1 1.6 1.2 1.3 1.4 0.91 YPL105C 0.6 0.8
0.6 0.7 1.1 1.2 0.7 1.0 3.4 1.4 0.6 0.7 1.0 0.6 1.1 0.5 0.8 0.6
0.80 YPR066W 1.2 2.2 1.1 2.2 1.3 0.7 1.3 0.8 2.3 1.9 0.9 0.8 1.4
1.2 0.7 1.6 1.1 1.2 0.41 YPR081C 0.9 1.0 1.0 1.1 0.8 1.1 1.1 1.0
4.2 2.6 0.9 1.0 1.4 1.1 1.3 1.8 0.9 1.3 0.34 YPR140W 0.9 1.2 0.8
1.8 0.9 3.0 1.9 1.1 2.1 1.3 0.8 0.8 1.3 1.4 1.7 2.4 0.8 1.3 0.47
YPR155C 0.9 2.5 1.5 1.4 0.9 0.9 1.4 1.0 2.0 1.3 0.9 0.9 1.3 1.2 0.5
3.4 0.8 1.6 0.40 YPR185W 0.7 0.9 0.3 0.4 1.1 0.9 1.2 1.0 2.5 1.7
0.9 0.8 1.7 1.0 1.1 1.3 1.3 1.1 0.68 YBR076W 2.3 1.1 1.4 5.0 0.9
0.8 1.0 0.7 0.4 1.8 0.8 0.9 1.9 1.2 1.1 0.5 1.4 1.2 0.36 YDR373W
1.7 0.8 0.5 1.3 1.8 0.9 1.4 1.9 2.5 2.8 1.7 0.5 1.0 2.1 1.6 1.4 1.2
1.6 1.08 YFR014C 2.1 2.4 0.8 2.6 0.7 0.8 1.4 1.3 1.0 1.6 1.8 0.9
1.3 1.0 0.6 2.3 1.2 2.9 0.94 YHR136C 2.4 13.6 1.4 2.1 2.4 1.4 0.5
1.3 0.1 2.0 2.0 1.2 0.3 1.7 0.5 1.3 1.6 2.5 1.33 YIL129C 0.8 5.8
1.0 1.2 0.3 2.1 1.8 1.5 1.9 0.9 1.0 1.0 1.3 0.8 0.25 YMR077C 1.1
3.9 1.1 1.8 1.0 0.5 1.4 1.7 1.9 2.5 1.5 0.9 0.8 1.6 1.7 2.3 0.9 1.3
0.59
YBR264C 1.2 3.7 1.5 1.5 0.7 0.9 1.3 1.2 0.9 1.1 1.0 1.0 0.9 1.6 1.1
1.8 0.9 1.3 0.61 YPL177C 1.2 3.7 0.9 1.3 0.7 0.8 0.8 1.3 0.5 1.0
1.4 0.8 0.8 1.3 0.6 1.9 1.2 1.1 0.75 YGL056C 0.7 3.5 1.3 1.0 0.6
0.4 1.0 0.9 0.4 0.6 0.0 1.1 0.8 1.1 1.2 1.5 0.9 1.1 0.47 YBL101W-A
1.0 5.7 0.7 0.6 1.0 1.4 1.3 1.5 1.2 2.1 1.2 1.1 2.0 1.5 2.1 1.1 1.3
1.2 1.24 YER072W 1.6 2.3 1.6 1.3 1.2 1.5 0.7 1.2 0.5 1.1 1.7 1.1
0.6 1.5 0.9 1.1 1.7 1.7 1.69 YMR112C 1.2 4.2 0.9 1.2 1.0 0.7 1.5
1.6 1.4 1.3 0.9 1.0 0.9 1.8 0.9 1.4 1.1 1.6 0.57 YJR058C 1.3 2.0
1.3 1.5 1.1 1.6 1.3 1.2 1.9 2.6 1.2 0.7 0.8 1.8 0.8 1.2 1.3 1.2
1.00 YML055W 1.7 2.3 0.6 2.0 0.9 1.2 1.7 1.7 1.0 1.4 1.4 1.0 1.7
1.9 0.6 1.4 1.2 1.5 1.08 YDR080W 0.9 1.8 0.5 0.6 1.2 1.5 1.6 1.2
1.7 2.6 1.2 1.0 2.0 1.1 1.2 1.7 1.2 1.3 0.68 YNR030W 0.6 2.1 2.2
0.7 0.8 1.2 1.0 0.6 1.0 1.4 1.2 0.8 1.5 0.6 1.1 0.4 0.9 0.8 1.19
YNL196C 1.1 1.8 1.4 1.3 0.9 1.2 1.0 0.7 0.5 2.2 0.7 1.0 2.2 1.2 0.8
2.1 1.1 1.2 0.50 YOR148C 1.4 1.4 0.5 1.8 0.9 0.9 1.2 1.5 0.8 0.8
1.3 0.9 1.4 1.4 1.0 1.3 1.0 1.3 1.08 YER029C 1.0 1.6 0.4 1.9 1.7
1.2 1.1 1.5 1.4 1.1 0.8 0.9 0.9 1.4 1.1 1.7 0.9 1.3 1.20 YLR360W
0.9 2.0 0.5 0.7 1.9 1.4 1.7 1.3 0.9 1.3 0.9 0.9 0.7 1.1 0.8 2.1 1.2
1.4 0.53 YGR239C 1.3 1.3 0.7 1.3 1.2 2.3 1.2 1.5 0.5 3.8 1.4 1.0
1.0 1.4 1.3 1.1 1.1 1.3 0.49 YDL229W 0.9 1.9 0.4 0.6 1.2 1.0 1.3
1.2 1.4 0.9 1.6 0.9 1.0 1.3 1.2 1.0 1.2 1.1 0.76 YJR027W 0.8 1.9
0.8 0.7 1.5 2.0 1.0 1.2 1.3 1.1 0.8 1.3 1.1 2.3 0.7 0.7 1.1 4.88
YKL198C 1.2 1.4 0.8 0.2 0.9 1.0 1.2 0.6 0.0 0.8 1.4 0.7 1.9 6.6 2.6
0.7 1.0 0.8 0.17 YBR031W 1.1 0.8 4.1 1.4 1.4 0.7 0.5 1.0 0.1 1.0
0.9 1.0 0.3 0.4 0.9 0.7 1.0 0.8 7.58 YBR118W 1.3 0.8 2.9 1.2 1.0
1.3 1.0 1.3 0.5 0.9 1.0 0.8 0.8 0.7 1.6 0.6 1.2 0.9 8.91 YCR106W
0.9 1.1 2.8 1.1 0.8 1.4 0.9 0.8 2.0 1.2 1.2 0.8 1.2 0.8 1.3 1.2 1.1
1.2 0.76 YDR012W 0.9 0.8 3.9 1.2 1.1 0.9 0.5 1.1 0.3 0.7 0.9 1.2
0.2 0.4 0.8 0.7 1.0 0.7 7.07 YDR134C 1.0 0.7 3.9 1.9 0.8 1.1 0.4
0.6 0.1 0.5 1.9 0.6 0.4 0.5 0.8 0.9 0.7 1.1 5.84 YDR276C 1.5 1.6
6.1 1.4 0.7 1.1 1.0 1.1 1.1 2.7 1.4 0.9 1.1 1.3 2.2 3.6 1.3 2.4
2.48 YGR279C 0.9 0.7 3.6 1.0 1.2 1.6 0.8 0.6 0.3 0.7 0.9 0.7 0.3
0.4 1.3 0.8 1.0 0.8 3.77 YJL059W 1.0 1.7 3.1 0.8 0.9 1.6 1.1 0.8
1.7 1.6 1.8 1.0 1.6 1.3 0.9 0.8 1.1 1.0 0.39 YKL056C 1.3 0.7 2.6
1.4 1.7 0.9 0.5 1.0 0.1 0.7 1.1 0.8 0.1 0.7 0.9 0.6 0.8 1.2 6.68
YKL097W-A 1.5 1.3 4.2 1.3 1.2 0.9 0.2 0.7 0.0 0.4 1.6 0.7 0.2 0.6
2.0 0.8 1.1 1.4 4.01 YNL209W 0.9 0.9 2.7 0.9 1.3 0.9 0.5 1.1 0.2
0.8 0.9 0.9 0.5 0.6 0.9 0.3 0.6 0.6 8.06 YNL307C 0.8 0.6 3.1 1.3
1.0 1.9 0.9 0.9 1.0 0.9 1.0 1.0 1.0 0.7 0.6 1.0 1.0 1.3 2.79
YPR028W 1.0 1.1 4.0 1.7 1.0 1.4 0.8 0.7 0.5 0.8 1.4 0.6 1.7 0.8 0.9
1.3 1.2 1.7 4.06 YPR149W 1.0 1.1 5.9 1.7 1.7 1.6 2.1 0.6 1.2 1.8
1.1 0.7 1.4 1.3 1.0 2.2 1.1 1.1 2.65 YAL016W 0.8 1.0 2.8 0.9 0.9
0.9 1.1 1.0 1.2 1.9 0.9 0.8 1.4 0.9 1.1 1.1 0.8 1.3 1.00 YBR283C
0.6 0.7 1.9 1.2 1.4 2.2 0.8 0.8 1.5 1.2 2.0 0.8 0.8 0.6 1.4 0.9 0.9
0.9 2.62 YBR286W 0.7 1.4 3.8 1.2 1.3 1.5 1.3 0.9 1.2 1.6 1.0 1.1
1.8 1.5 1.3 2.6 0.8 1.6 2.98 YCL008C 0.8 1.1 1.8 1.2 1.2 0.9 0.9
0.7 0.9 1.4 0.9 0.9 1.0 0.9 1.4 0.6 0.9 0.9 0.47 YCR069W 1.0 1.2
2.0 0.9 1.1 1.4 1.1 0.7 0.8 0.7 1.3 1.4 1.6 1.0 2.4 1.2 1.2 1.3
0.97 YDL061C 1.4 0.5 2.9 0.9 1.3 1.1 0.5 1.0 0.0 0.5 1.4 1.0 0.1
0.7 1.0 0.6 1.1 1.0 4.40 YDR151C 1.3 1.0 2.3 1.8 0.8 0.7 0.8 1.5
2.6 2.8 2.1 0.9 2.8 1.1 0.6 1.2 0.8 1.1 0.96 YDR382W 1.3 0.5 2.4
1.2 1.1 0.6 0.4 1.2 0.0 0.4 1.2 0.7 0.1 0.7 1.1 0.4 1.0 1.0 6.40
YDR385W 0.6 0.4 3.5 0.9 1.1 0.5 0.4 0.7 0.2 0.5 0.9 0.9 0.3 0.5 0.8
0.3 0.6 0.4 7.27 YDR407C 0.7 1.0 2.0 0.7 0.8 1.2 1.4 0.9 1.5 1.7
1.2 1.0 1.3 0.8 1.3 1.0 0.9 0.9 0.52 YGL206C 0.4 3.5 2.0 0.5 0.6
0.8 0.8 0.5 0.7 0.7 0.9 0.7 1.1 0.8 1.3 0.6 0.8 1.0 1.04 YGR172C
0.6 1.3 2.5 1.3 0.6 0.9 1.0 0.8 0.4 1.1 0.8 0.8 0.7 1.1 1.9 1.0 1.1
1.1 0.94 YIL015W 1.1 1.7 2.0 2.5 0.9 0.4 0.9 0.9 0.3 1.1 0.8 0.9
0.8 5.9 1.1 0.8 0.8 1.0 0.17 YIL018W 1.0 0.4 2.3 1.4 0.9 0.4 0.8
0.0 0.3 1.2 0.6 0.0 0.6 0.6 0.4 0.8 0.8 6.27 YJL138C 1.0 0.7 2.3
1.4 0.9 0.8 0.8 1.2 0.2 0.7 1.2 0.8 0.3 0.7 0.9 0.6 0.9 1.0 7.38
YJL191W 1.0 0.4 2.2 0.7 1.3 1.0 0.8 0.0 0.4 1.1 1.0 0.9 1.1 0.7 2.2
1.0 1.0 1.86 YJR047C 1.1 0.8 2.6 1.1 1.1 1.1 0.4 0.9 0.7 0.5 1.1
0.9 0.9 0.9 0.6 0.8 0.8 0.9 5.29 YJR119C 0.9 1.0 2.0 1.0 0.9 1.4
1.1 1.6 0.5 1.3 1.1 0.9 1.2 1.3 1.5 1.0 0.7 0.9 0.30 YJR123W 1.2
0.6 2.2 1.0 1.3 1.0 0.4 1.2 0.0 0.5 0.9 0.8 0.1 0.6 1.1 0.4 0.8 0.9
7.84 YJR145C 0.8 0.7 2.3 1.3 0.4 0.4 1.0 0.0 0.4 0.8 0.6 0.0 0.6
0.8 0.5 0.8 0.9 4.82 YLR110C 1.4 0.8 2.7 1.2 1.7 0.9 0.4 0.8 0.3
0.8 3.2 0.7 0.5 0.5 1.7 0.8 0.9 1.1 3.99 YLR264W 1.1 0.4 2.2 1.0
1.1 0.7 0.4 1.0 0.0 0.3 0.8 1.1 0.3 1.2 1.2 0.5 1.0 1.1 3.91
YLR340W 0.8 0.4 2.6 1.0 0.6 0.7 0.3 0.9 0.0 0.5 1.4 0.9 0.1 0.5 1.3
0.2 0.9 0.7 6.55 YLR388W 1.6 0.4 1.9 1.0 2.5 0.7 0.5 1.2 0.2 0.7
1.0 0.6 0.1 0.8 0.6 0.5 0.8 1.0 4.48 YMR092C 0.6 1.2 1.9 1.3 0.8
0.9 1.2 0.9 1.5 1.7 1.2 0.9 1.7 0.8 1.1 1.2 0.9 1.3 1.43 YMR101C
1.1 1.8 1.9 2.9 0.9 0.4 0.9 0.8 -4.0 1.6 -0.3 0.7 0.8 1.1 1.0 0.9
0.7 0.8 0.16 YNL069C 1.2 0.3 2.8 2.3 0.7 0.4 0.3 1.0 0.0 0.4 1.0
0.6 0.1 0.9 1.0 0.3 0.8 0.6 4.03 YNL135C 1.1 0.9 2.0 1.4 1.7 0.9
0.8 0.5 0.7 0.5 0.7 0.8 0.9 0.5 1.0 1.4 1.2 1.7 3.05 YOL039W 1.2
0.3 3.9 0.7 1.3 0.4 0.3 1.0 0.0 0.9 1.1 0.7 0.1 0.5 0.8 0.4 0.7 0.7
4.94 YOL120C 1.0 0.3 2.3 0.8 1.5 0.3 0.4 0.8 0.0 0.3 1.0 0.7 0.1
0.6 0.6 0.3 0.6 0.8 4.42 YOR230W 1.2 2.3 3.0 1.0 0.9 1.1 0.6 0.6
0.6 0.7 1.6 1.4 1.5 0.7 0.6 1.6 1.2 1.6 1.76 YOR298W 0.9 0.9 3.2
0.5 1.5 0.9 0.6 0.7 0.6 1.0 0.1 0.7 1.1 2.1 1.2 0.5 1.0 0.8 0.41
YPL048W 0.7 0.7 2.6 1.2 0.7 0.6 0.6 0.8 1.6 0.6 1.7 1.0 0.9 0.6 1.5
1.3 1.2 1.0 2.11 YPL179W 1.0 1.5 2.4 1.0 1.1 1.6 1.2 0.8 1.2 1.1
1.1 1.0 1.3 0.8 1.2 1.4 1.3 1.3 1.38 YPL218W 1.5 0.9 2.5 1.7 1.1
1.5 1.3 1.4 1.1 1.2 1.1 1.2 1.0 1.5 1.1 1.7 1.1 1.8 2.98 YPL220W
1.3 0.9 2.3 1.4 1.1 1.3 0.6 1.2 0.0 0.5 1.3 0.5 0.1 0.6 0.6 0.5 1.1
1.1 8.33 YPR080W 1.3 1.3 2.8 1.2 1.4 1.4 0.9 1.3 0.7 1.1 1.0 1.0
1.3 0.6 1.5 0.6 1.1 1.0 8.03 YPR181C 0.5 0.8 2.3 0.6 1.0 2.0 1.3
0.5 1.0 0.7 1.3 1.0 1.7 2.4 1.5 1.6 1.8 1.6 1.84 YBR290W 1.3 1.4
0.8 3.0 1.0 1.1 1.4 1.5 2.0 1.8 1.2 1.0 1.7 1.4 0.9 1.3 1.2 2.1
1.34 YCR091W 1.3 1.1 0.6 2.2 1.3 1.3 1.3 1.1 0.8 1.2 0.8 1.1 1.3
1.3 0.7 2.7 1.3 1.4 0.22 YFL026W 1.0 0.8 1.2 5.0 1.4 1.0 1.2 1.3
0.6 1.5 1.3 0.8 1.1 1.1 1.0 1.0 1.0 1.0 0.27 YOR003W 0.9 1.1 1.3
3.3 1.6 1.1 1.1 0.9 1.6 1.3 0.7 0.8 1.0 1.2 2.8 1.3 1.0 1.1 0.30
YCR038C 0.9 1.1 0.9 2.5 0.9 0.9 0.9 0.9 0.7 0.7 1.1 0.8 1.0 1.1 0.7
1.0 0.9 1.1 0.31 YDL119C 1.0 0.8 0.6 2.2 0.9 0.6 1.3 1.1 1.3 1.1
1.5 0.9 1.1 1.2 0.5 1.2 1.0 1.0 0.77 YDL220C 0.9 1.3 1.1 1.6 1.2
1.8 1.1 0.8 0.2 1.3 0.8 1.0 1.6 0.9 1.6 0.8 1.1 0.9 0.24 YDR125C
1.1 0.9 1.0 1.7 1.1 0.8 1.0 1.2 0.7 1.9 1.0 0.8 0.9 1.0 0.8 1.7 0.9
1.2 0.35 YDR225W 1.0 0.6 0.6 1.6 1.9 0.5 0.4 0.8 0.3 0.7 2.7 0.4
0.2 0.8 0.1 0.8 1.1 1.8 5.54 YER066W 0.9 0.7 0.9 2.1 1.5 1.3 1.3
0.7 1.7 1.4 1.5 0.7 0.9 1.1 0.5 3.3 1.1 1.1 0.66 YER076C 0.8 0.9
1.2 1.9 1.1 0.6 0.8 0.7 0.2 1.2 0.7 0.7 1.1 0.9 0.8 1.3 1.0 1.0
0.33 YFR006W 0.9 1.8 1.1 3.4 0.7 0.8 1.4 1.0 -1.6 0.7 1.2 1.0 0.9
0.9 0.8 1.2 0.9 1.3 1.54 YGL208W 0.9 1.8 1.1 2.2 0.7 0.6 1.1 0.7
1.4 1.3 1.3 0.8 1.5 0.9 1.8 3.1 0.8 1.3 0.32 YGR023W 1.0 0.9 1.1
4.2 1.0 1.2 1.0 1.2 1.2 3.2 2.4 0.9 1.4 1.3 1.1 0.9 1.2 1.5 0.69
YGR108W 0.9 3.9 0.3 3.6 0.8 0.1 0.3 0.5 0.0 0.1 0.5 0.4 0.3 0.8 0.2
0.4 0.7 1.0 0.93 YHR195W 1.1 1.5 0.6 2.4 1.5 1.0 1.3 1.6 1.8 0.8
1.4 0.9 1.2 1.2 0.7 3.7 1.0 1.5 1.12 YIL050W 1.0 1.3 1.3 2.4 0.9
0.7 1.1 1.2 1.3 1.9 0.9 1.0 1.0 1.3 0.6 2.7 1.0 1.1 0.52 YJR050W
1.0 0.6 0.7 2.1 1.2 1.4 1.1 1.8 2.0 1.3 0.8 0.8 1.9 1.3 0.9 1.5 0.9
1.1 0.85 YKL093W 1.0 1.6 1.4 3.6 0.8 0.8 0.7 0.9 1.5 1.6 0.9 0.9
1.2 1.1 0.8 2.9 0.8 1.0 0.38 YMR053C 1.1 1.0 0.8 2.1 0.9 1.3 0.9
1.0 2.2 1.4 1.3 0.9 1.5 1.3 2.4 2.3 1.1 1.6 0.31 YNL139C 0.8 1.1
0.8 2.0 1.9 1.0 1.0 0.9 0.6 0.7 0.8 0.5 1.2 0.7 1.4 1.1 1.1 1.0
0.47 YOR122C 1.0 0.7 1.8 1.9 1.7 1.3 1.2 1.0 1.1 0.9 1.5 0.8 1.0
1.2 1.6 1.5 1.0 2.2 3.06 YOR312C 1.2 0.4 1.0 1.9 0.7 0.6 0.6 1.2
0.0 0.3 0.8 0.7 0.1 0.7 0.7 0.5 1.2 1.0 5.24 YOR327C 2.3 1.8 0.5
1.9 1.0 1.4 1.4 1.9 1.4 2.2 2.1 1.0 2.1 1.5 0.9 1.5 2.2 2.1 1.46
YPL001W 0.9 0.9 1.0 2.5 1.7 0.7 1.0 1.2 0.7 1.0 1.3 0.7 0.8 1.3 1.3
0.8 0.9 1.2 0.74 YPL230W 1.2 1.7 1.8 4.0 0.8 1.0 1.1 1.0 0.9 2.7
3.1 1.0 2.0 1.3 0.7 2.0 1.0 1.6 0.47 YER025W 0.6 0.7 0.6 0.6 1.5
1.0 1.5 1.1 0.4 0.6 1.2 0.7 0.6 2.1 0.8 2.6 1.8 2.3 1.96 YHR185C
0.9 1.1 1.4 0.7 1.4 1.0 1.3 0.8 -0.6 0.9 0.7 0.8 0.4 1.7 1.3 3.2
1.4 3.0 1.64 YIL076W 1.3 0.6 1.1 1.0 1.8 0.6 0.5 1.3 1.0 1.4 1.1
0.8 0.8 1.4 1.0 0.8 1.2 2.5 3.73 YMR238W 1.9 1.3 1.1 1.3 1.5 1.3
1.2 0.9 1.3 1.4 1.2 1.0 1.5 1.2 2.3 1.4 2.2 2.4 1.36 YBR009C 1.6
0.8 0.4 1.7 1.4 1.0 0.5 1.2 0.6 0.6 0.8 0.5 0.4 1.1 0.2 0.4 1.0 2.4
7.00 YBR010W 1.0 0.8 0.5 2.0 0.8 1.1 0.8 1.3 0.5 0.7 1.0 0.7 0.4
1.0 0.3 0.8 1.1 2.3 7.25 YCL067C 1.2 1.1 0.3 1.7 1.1 1.7 1.3 1.7
1.4 1.9 1.6 1.0 1.4 2.1 2.2 1.7 0.8 2.2 3.15 YCR096C 1.1 0.9 0.4
1.6 2.1 1.2 1.7 1.5 1.2 1.6 1.4 1.0 1.0 2.1 2.1 1.8 1.0 2.1 2.34
YDL137W 1.4 1.1 1.2 1.2 1.8 1.0 2.0 1.1 1.1 1.3 1.5 1.6 1.7 1.4 1.3
2.3 1.3 2.2 4.95 YDL192W 1.4 1.0 0.6 1.2 1.4 1.0 1.7 1.5 0.8 0.6
1.3 1.1 0.9 1.2 1.3 1.3 1.1 2.3 5.57 YDR224C 1.1 0.7 0.8 0.9 1.2
1.0 0.8 1.4 1.1 1.3 1.1 0.7 0.5 1.7 0.3 1.1 1.2 2.2 5.62 YDR378C
1.3 1.3 1.4 1.3 1.0 1.0 1.4 1.5 0.5 1.3 0.8 0.9 0.8 1.4 0.8 1.0 1.7
2.2 2.40 YMR197C 1.3 1.6 1.4 1.9 1.1 1.6 1.5 1.4 1.9 2.5 1.0 1.1
1.5 4.1 1.7 1.9 1.2 2.2 1.20 YOL109W 2.0 2.0 1.5 1.8 1.0 1.3 1.2
1.5 0.1 1.1 1.0 0.8 0.5 1.4 1.0 0.8 1.6 2.2 4.13 YPL010W 1.0 1.1
0.9 1.0 1.4 1.0 1.9 1.5 1.7 1.5 1.3 1.1 1.1 1.3 1.2 1.3 1.3 2.0
3.25 YHR132C 0.8 0.7 1.7 1.4 1.0 0.7 0.8 0.8 0.9 1.1 1.1 0.8 1.2
0.9 1.4 2.3 0.8 1.3 1.52 YJL141C 1.0 0.8 1.0 1.6 1.5 1.1 1.1 0.9
1.2 1.3 1.2 0.8 1.4 0.8 0.8 2.2 1.4 1.6 0.94 YKR098C 1.0 1.1 1.2
1.7 1.1 1.8 1.7 1.3 1.4 2.7 1.9 1.1 1.4 1.4 0.9 3.9 1.1 1.6 0.55
YLR206W 0.7 1.6 1.4 1.1 1.1 0.5 0.7 0.8 1.5 1.0 1.3 0.8 1.4 0.8 2.4
2.3 1.1 1.2 0.72 YAL055W 1.2 1.0 0.9 1.0 1.4 1.3 1.5 1.9 1.0 1.4
1.3 1.2 1.5 1.6 1.1 2.6 1.3 1.3 0.62 YAR062W 1.2 1.8 1.4 0.7 1.0
0.6 1.3 0.9 0.4 0.9 -1.1 0.8 1.2 1.1 1.3 2.4 0.9 1.0 0.32 YBL102W
0.8 1.0 1.4 1.2 0.9 2.5 1.6 0.8 2.3 1.1 1.2 0.9 1.7 1.1 1.1 2.0 2.4
1.5 1.26 YBR161W 1.2 0.8 2.3 0.7 1.1 3.0 0.9 0.4 0.4 1.1 0.6 1.0
0.9 1.5 2.1 1.5 2.2 0.72 YCR039C 1.9 2.1 0.3 0.9 1.9 1.5 1.4 1.6
1.8 2.2 1.2 0.8 1.0 1.7 1.9 2.1 1.0 2.1 1.73 YDL018C 1.3 0.9 0.9
1.1 1.8 1.4 1.2 1.3 1.0 1.0 0.9 0.7 1.0 1.5 1.1 3.1 1.5 1.7 0.84
YDR022C 1.1 1.2 0.8 0.9 1.5 2.2 1.8 1.4 0.9 1.4 0.9 0.7 1.3 2.1 1.0
2.1 1.3 1.2 0.47 YDR181C 1.1 1.2 0.8 1.4 0.9 0.7 1.0 1.2 2.0 0.9
0.8 0.7 0.7 1.3 1.2 2.0 0.8 1.2 0.48 YGR036C 0.9 0.8 0.9 1.1 1.3
1.3 1.0 0.8 0.9 0.9 0.9 1.0 1.3 1.0 0.7 2.0 1.3 1.1 1.12 YGR120C
1.2 1.8 0.5 1.0 1.8 1.5 1.6 1.3 0.3 1.2 1.1 0.7 0.5 1.0 1.2 1.9 1.1
1.2 0.36 YGR131W 0.8 2.1 1.9 1.1 0.9 1.9 1.1 1.1 1.9 5.8 1.1 0.5
1.4 2.0 0.8 2.6
1.3 1.0 0.41 YGR167W 1.1 1.1 0.6 1.5 0.9 1.7 1.4 1.4 1.4 1.9 1.1
1.1 1.6 1.7 1.6 2.8 1.3 1.7 1.79 YHL024W 1.2 0.8 1.6 1.1 1.5 1.2
1.3 0.8 2.1 3.6 1.1 1.6 1.6 2.1 2.9 3.8 1.4 1.4 0.58 YJL113W 1.2
1.9 1.2 1.2 0.7 1.2 1.3 1.3 2.1 1.2 0.7 0.9 1.3 1.7 2.1 0.9 1.5
0.41 YJL146W 1.3 1.9 1.2 2.0 0.8 0.7 1.3 1.0 1.0 1.7 -1.1 1.1 0.8
1.5 1.2 1.8 1.0 1.3 0.30 YJR019C 0.8 1.8 1.9 1.6 1.1 0.8 0.9 0.7
1.1 0.6 2.4 1.1 1.4 0.8 1.1 2.6 1.8 1.4 0.33 YJR049C 1.0 1.2 1.0
1.0 0.7 0.6 1.0 1.2 1.4 1.4 1.6 1.0 2.1 1.2 1.2 1.7 0.9 1.2 0.44
YLR078C 0.9 1.1 0.7 1.4 0.8 1.2 1.1 0.8 1.1 2.9 1.0 0.8 1.2 0.6 2.2
1.2 1.2 1.02 YNR037C 0.9 0.9 0.9 1.7 1.2 0.7 1.7 1.1 1.3 1.7 1.5
0.7 2.0 1.2 0.8 1.9 1.4 1.6 1.34 YOR028C 1.4 0.7 1.1 2.3 1.6 1.0
1.2 1.5 1.2 2.0 1.5 0.6 0.8 1.3 1.1 3.7 0.8 1.7 0.78
[0034] The tables show that the expressed mRNA of about 700 of 2400
unknown yeast genes was induced by any one of toxic chemical
substances such as heavy metals, agricultural chemicals,
surfactants (Table 1), as well as the expressed mRNA of 167
mitochondria-located genes (Table 2), 52 DNA repair genes (Table
3), 161 energy genes (Table 4), 142 transport facilitation genes
(Table 5), 90 stress protein genes (Table 6), 142 metabolism genes
(Table 7), 60 detoxification genes (Table 8), and 507 genes
belonging to other category (Table 9). Here, when the value of the
following is 2 or more, then it is considered significant: The
.times. .times. level .times. .times. of .times. .times. expressed
.times. .times. mRNA .times. .times. in .times. .times. the .times.
.times. presence .times. .times. of .times. .times. chemical
.times. .times. substance The .times. .times. level .times. .times.
of .times. .times. expressed .times. .times. mRNA .times. .times.
in .times. .times. the .times. .times. absence .times. .times. of
.times. .times. chemical .times. .times. substance . ##EQU2##
[0035] "Intensity" indicated in the rightmost column of Tables 1 to
9 is a value of the level of expressed mRNA of each gene in control
cells as divided by the average level of the expressions of the
whole genes. When the intensity is low, the error of measurement
may be possibly large. The detection is considered more precise
when expression magnification (expressed mRNA in the presence of
chemical substance/expressed mRNA in the absence of chemical
substance) is larger. Yeast gene as used in the processes according
to the invention is selected, of which the intensity is preferably
0.3 or more, more preferably 0.5 or more, and of which the
expression magnification is preferably 3 or more, more preferably 5
or more.
* * * * *