U.S. patent application number 11/586724 was filed with the patent office on 2007-12-13 for plasma method for tiox biomedical material onto polymer sheet.
This patent application is currently assigned to ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCH. Invention is credited to Chia-Chieh Chen, Ko-Shao Chen, Lie-Hang Shen, Nini-Chen Tsai, Te-Hsing Wu, Yi-Chun Yeh.
Application Number | 20070286942 11/586724 |
Document ID | / |
Family ID | 38822311 |
Filed Date | 2007-12-13 |
United States Patent
Application |
20070286942 |
Kind Code |
A1 |
Wu; Te-Hsing ; et
al. |
December 13, 2007 |
Plasma method for TiOx biomedical material onto polymer sheet
Abstract
A biomedical material is prepared through a plasma method. The
material is a film containing titanium oxide onto polymer sheet.
The film is hydrophilic, bacterial inactivated and biocompatible.
The present invention can be applied to artificial guiding tube and
wound dressing material.
Inventors: |
Wu; Te-Hsing; (Taoyuan City,
TW) ; Chen; Ko-Shao; (Taipei City, TW) ; Chen;
Chia-Chieh; (Longtan Township, TW) ; Shen;
Lie-Hang; (Jhongli City, TW) ; Yeh; Yi-Chun;
(Cihtong Township, TW) ; Tsai; Nini-Chen; (Puzih
City, TW) |
Correspondence
Address: |
TROXELL LAW OFFICE PLLC
SUITE 1404, 5205 LEESBURG PIKE
FALLS CHURCH
VA
22041
US
|
Assignee: |
ATOMIC ENERGY COUNCIL-INSTITUTE OF
NUCLEAR ENERGY RESEARCH
Taoyuan
TW
|
Family ID: |
38822311 |
Appl. No.: |
11/586724 |
Filed: |
October 26, 2006 |
Current U.S.
Class: |
427/2.31 |
Current CPC
Class: |
C23C 18/1233 20130101;
A61L 31/088 20130101; A61L 29/106 20130101; C08J 2367/04 20130101;
C23C 18/1287 20130101; C23C 18/1254 20130101; A61L 27/306 20130101;
C23C 18/1216 20130101; A61L 29/14 20130101; C08J 7/06 20130101;
C23C 18/127 20130101; A61L 27/50 20130101; C23C 18/1291 20130101;
C23C 18/143 20190501; A61L 31/14 20130101; C08J 2327/18
20130101 |
Class at
Publication: |
427/2.31 |
International
Class: |
B05D 3/00 20060101
B05D003/00 |
Foreign Application Data
Date |
Code |
Application Number |
Jun 9, 2006 |
TW |
095120474 |
Claims
1. A plasma method for a titanium oxide (TiO.sub.x) biomedical
material onto polymer sheet, comprising steps of: (a) obtaining a
hydrophilic polymer film through a sol-gel method to be coated with
an organic titanium (Ti) solution; and (b) processing a plasma
activation treatment to said hydrophilic polymer film under a
vacuum pressure with oxygen (O.sub.2) having a pressure to obtain a
TiO.sub.x film onto polymer sheet.
2. The method according to claim 1, wherein said hydrophilic
polymer film in step (a) is made of a material selected from a
group consisting of hexamethyldisilazane (HMDSZ), itaconic acid and
acryl amide.
3. The method according to claim 1 wherein said sol-gel method in
step (a) comprises steps of: (a1) solving a precursor of Ti
Isopropoxide (TIP) into an organic solution; (a2) obtaining an
organic Ti solution from said organic solution by using ultrasonic
waves; and (a3) spin-coating a layer of said organic Ti solution on
a surface of said hydrophilic polymer film.
4. The method according to claim 1, wherein said vacuum pressure in
step (b) is a pressure below 50 mtorr.
5. The method according to claim 1 wherein said O.sub.2 in step (b)
has a pressure between 150 mtorr and 250 mtorr.
6. The method according to claim 1 wherein said plasma activation
treatment in step (b) is processed for more than 10 minutes (min)
under a working power greater than 50 watts (W).
7. The method according to claim 1, wherein said polymer sheet in
step (b) is made of a material selected from a group consisting of
a stretchable Teflon and a poly lactic-co-glycolic acid (PLGA).
8. A plasma method for a TiO.sub.x biomedical material onto polymer
sheet, comprising steps of: (a) obtaining a hydrophilic polymer
film and coating said hydrophilic polymer film with an organic Ti
solution through a sol-gel method; (b) processing a plasma
activation treatment to said hydrophilic polymer film under a
vacuum pressure below 50 mtorr with O.sub.2 having a pressure
between 150 mtorr and 250 mtorr to obtain a TiO.sub.x film onto
polymer sheet; and (c) processing a copolymerization in a surface
grafting to said TiO.sub.x film onto polymer sheet.
9. The method according to claim 8, wherein said hydrophilic
polymer film in step (c) is made of a material having a hydrophilic
HMDSZ; and wherein said material is selected from a group
consisting of a stretchable Teflon and a PLGA.
10. The method according to claim 8, wherein said sol-gel method in
step (a) comprises steps of: (a1) solving a precursor of TIP into
an organic solution; (a2) obtaining an organic Ti solution from
said organic solution by using ultrasonic waves; and (a3)
spin-coating a layer of said organic Ti solution on a surface of
said polymer film having hydrophilic HMDSZ.
11. The method according to claim 8, wherein said plasma activation
treatment in step (b) is processed under a working power between 10
W and 100 W.
12. The method according to claim 8, wherein said plasma activation
treatment in step (b) is processed for a period between 5 min and
100 min.
13. The method according to claim 8, wherein said copolymerization
in said surface grafting in step (c) comprises steps of: (c1)
deposing said TiO.sub.x film onto polymer sheet in a solution of
N-Vinyl-2-pyrrolidinone (NVP) and adding an amount of a vitamin B2
solution to said NVP solution and processing nitrogen for a period
of time; (c2) irradiating said NVP solution having said TiO.sub.x
film onto polymer sheet with an ultra-violet (UV) light; and (c3)
moving out said TiO.sub.x film onto polymer sheet to be washed with
a distilled water to remove homopolymer and unreacted monomer.
14. The method according to claim 13, wherein a mixture rate of
said NVP solution and said vitamin B2 solution in step (c1) is
10:1.
15. The method according to claim 8, wherein said NVP solution in
step (c1) has an amount lesser than 30 weight percents (wt %).
16. The method according to claim 13, wherein said nitrogen in step
(c1) is processed shorter than 30 min.
17. The method according to claim 13, wherein said UV light in step
(c2) is irradiated for a period between 5 min and 30 min.
18. The method according to claim 13, wherein said washing in step
(c3) is shorter than 40 hours.
Description
FIELD OF THE INVENTION
[0001] The present invention relates to a plasma method; more
particularly, relates to preparing a biomedical material having
hydrophile, photo-induced inactivation and bio-compatibility.
DESCRIPTION OF THE RELATED ART
[0002] Environment protection and health caring are two of the
major concerns to human's life today. Green productions and health
caring medicines therefore become more and more popular. Titanium
dioxide (TiO.sub.x) is a semiconductor having great abilities in
oxidation and reduction and is made into a photo catalysis widely
used for defogging, deodorizing and sterilizing. Regarding the
fabric base for TiO.sub.x, porous polymer is used. For example,
stretchable Teflon, like expanded PTFE (ePTFE), is porous, safe and
biocompatible and is suitable to be applied in a nano-grade
processed material. But, stretchable Teflon is a bioinert material
and is a non-decomposable material having a water repellent
surface. Thus, a surface modification is required for such a
material to function well.
[0003] There are a few methods for the surface modification. One
which uses low-temperature plasma does not destroy surface
structure and can be operated under a normal environment with low
pollution. A prior art for preparing a temporary wound dressing by
surface grafting polymerization with gamma-ray irradiation is
revealed. The prior art uses a plasma or a gamma-ray irradiation on
a material surface for grafting with a hydrophilic monomer, like
acrylamide or itaconic acid, to improve hydrophile for hydrophilic
decomposable polymer. Then a nonwoven wound dressing is made
easy-stripped. Finally, a biodegradable material, like gelatin,
chondroitin-6-sulfate or chitosan, is fixed on the surface of the
dressing with special functional group, like --NH.sub.2,
polymerized on a grafting layer. By doing so, a biocompatibility is
gained to help histiocyte on regenerating and repairing. On
considering that wound is apt to be infected by germs in the air,
an anti-bacterial agent is further applied to prevent unwanted
result to the wound owing to infection. The dressing is processed
through a gamma-ray irradiation or a plasma activation treatment
and is processed with a surface grating polymerization using a
monomer, like a thermo-sensitive monomer of N-isopropylacrylamide
(NIPAAm), a water-soluble monomer of acrylamide (AAm) or an
itaconic acid. Or, the dressing is directly processed through a
grating polymerization with gamma-ray for surface grating. Hence,
an immobilization with chemical cross linking is used to fix
different biodegradable protein to obtain biodegradability and
regeneration ability. In the other hand, different fixing methods
are applied to different contact area of air, coordinated with
different chemical structures of anti-bacterial agents.
[0004] Although the above prior art prepares an anti-bacterial and
hydrophilic biomedical material, the procedure is complex and a few
agent are required. Hence, the prior art does not full users'
requests on actual use.
SUMMARY OF THE INVENTION
[0005] The main purpose of the present invention is to prepare a
biomedical material having hydrophile, photo-induced inactivation
and bio-compatibility through a surface modification with plasma to
obtain a hydrophilic polymer film, where the procedure is simple
and no additional agent of initiator or catalyst is required.
[0006] To achieve the above purpose, the present invention is a
plasma method for a TiO.sub.x biomedical material onto polymer
sheet, comprising steps of: (a) obtaining a hydrophilic polymer
film to be coated with an organic titanium solution through a
sol-gel method; and (b) processing a plasma activation treatment
with oxygen having a pressure to the hydrophilic polymer film under
a vacuum pressure to obtain a TiO.sub.x film onto polymer sheet,
where the TiO.sub.x film onto polymer sheet obtained after step (b)
is further processed through a copolymerization in surface grafting
to enhance hydrophile and to increase sterilized are a on a surface
of the polymer film. Accordingly, a novel plasma method for a
TiO.sub.x biomedical material onto polymer sheet is obtained.
BRIEF DESCRIPTIONS OF THE DRAWINGS
[0007] The present invention will be better understood from the
following detailed descriptions of the preferred embodiments
according to the present invention, taken in conjunction with the
accompanying drawings, in which
[0008] FIG. 1 is the view showing the flow chart according to the
present invention;
[0009] FIG. 2 is the view showing the flow chart of the first
preferred embodiment;
[0010] FIG. 2A is the view showing the Fourier transform infrared
spectrum of the first preferred embodiment;
[0011] FIG. 2B to FIG. 2D are the views showing the distribution
curves of the first, the second and the third elements of the first
preferred embodiment;
[0012] FIG. 3 is the view showing the flow chart of the second
preferred embodiment;
[0013] FIG. 3A to FIG. 3C are the views showing the distribution
curves of the first, the second and the third elements of the
second preferred embodiment;
[0014] FIG. 4 is the view showing the flow chart of the third
preferred embodiment;
[0015] FIG. 4A is the view showing the flow chart of step (c);
[0016] FIG. 4B and FIG. 4C are the first and the second views
showing the water contact angle; and
[0017] FIG. 4D is the view showing the anti-bacterial effect.
DESCRIPTIONS OF THE PREFERRED EMBODIMENTS
[0018] The following descriptions of the preferred embodiments are
provided to understand the features and the structures of the
present invention.
[0019] Please refer to FIG. 1, which is a view showing a flow chart
according to the present invention. As shown in the figure, the
present invention is a plasma method for a titanium oxide
(TiO.sub.x) biomedical material onto polymer sheet, comprising the
following steps:
[0020] (a) Obtaining a hydrophilic polymer film to be coated with
an organic titanium (Ti) solution 11: A hydrophilic polymer film is
obtained through a sol-gel method to be coated with an organic Ti
solution, where the hydrophilic polymer film is a polymer film made
of hexamethyldisilazane (HMDSZ), itaconic acid or acrylamide; and
the polymer film is a stretchable Teflon or a poly
lactic-co-glycolic acid (PLGA). The sol-gel method comprises steps
of: (i) solving a precursor of Ti Isopropoxide (TIP) into an
organic solution; (ii) obtaining an organic Ti solution by using
ultrasonic waves; and (iii) spin-coating the organic Ti solution on
the hydrophilic polymer film.
[0021] (b) Processing a plasma activation treatment 12: certain
pressure of oxygen (O.sub.2) is accessed to the hydrophilic polymer
film coated with the organic Ti solution for processing a plasma
activation treatment under a certain vacuum pressure with an
O.sub.2 plasma to obtain a TiO.sub.x film onto polymer sheet. There
in, the vacuum pressure is lower than 50 mtorr; the pressure for
O.sub.2 is between 150 and 250 mtorr; and the working power for the
O.sub.2 plasma is greater than 10 watts (W).
[0022] Thus, a TiO.sub.x biomedical material onto polymer sheet is
obtained.
[0023] Please refer to FIG. 2, which is a view showing a flow chart
of a first preferred embodiment. As shown in the figure, a
hydrophilic polymer film used in a first preferred embodiment is a
stretchable Teflon having hydrophilic HMDSZ to obtain a TiO.sub.x
biomedical material onto polymer sheet according to the present
invention, comprising the following steps:
[0024] (a) Obtaining a stretchable Teflon having hydrophilic HMDSZ
to be coated with an organic Ti solution 21: A stretchable Teflon
having hydrophilic HMDSZ is obtained through a sol-gel method to be
coated with an organic Ti solution, where the sol-gel method
comprises steps of: (i) solving a precursor of TIP into an organic
solution; (ii) obtaining an organic Ti solution by using ultrasonic
waves; and (iii) spin-coating the organic Ti solution on the
stretchable Teflon having hydrophilic HMDSZ.
[0025] (b) Processing a plasma activation treatment 22: An O.sub.2
having a pressure between 150 and 250 mtorr is accessed to the
stretchable Teflon coated with the organic Ti solution for
processing a plasma activation treatment under a 50 mtorr vacuum
pressure, where the working power is greater than 10 W and the
plasma activation treatment is processed for a time between 10 and
100 minutes (min). Thus, a TiO.sub.x film onto a stretchable Teflon
is obtained.
[0026] Please refer to FIG. 2A, which is a view showing a Fourier
transform infrared spectrum of the first preferred embodiment. As
shown in the figure, a Fourier transform infrared spectroscopy
analysis is processed to a stretchable Teflon coated with an
organic Ti solution, and a TiO.sub.x film onto polymer sheet after
a plasma activation treatment, to obtain a first spectrum curve 23
and a second spectrum curve 24, respectively. A Ti--O
characteristic absorption peak 231 is found at a wave number about
699 cm.sup.-1 on the first spectrum curve 23; a C--H peak 232, at
about 2952 cm.sup.-1; and a O--H peak 233, at about 3600
cm.sup.-1.
[0027] The second spectrum curve 24 shows a Ti--O characteristic
absorption peak 241 like the first spectrum curve 23. After the
plasma activation treatment, the organic material in the organic Ti
solution is dissolved out from the stretchable Teflon coated with
the organic Ti solution and is oxidized. The originally weak Ti--O
characteristic absorption peak 231 is thus enhanced to obtain the
Ti--O characteristic absorption peak 241 of the second spectrum
curve 24 after the plasma activation treatment, where a C--O
characteristic absorption peak 242 is also shown at a wave number
between 900 and 1100 cm.sup.-1. Thus, a Ti--O linking film is
formed on a surface of a polymer film of stretchable Teflon to
obtain a TiO.sub.x film on stretchable Teflon according to the
present invention.
[0028] Please refer to FIG. 2B, which is a view showing a
distribution curve of a first element of the first preferred
embodiment. As shown in the figure the TiO.sub.x film on the
stretchable Teflon is processed through an electron spectroscopy
for chemical analysis to obtain a distribution curve of a first
chemical element 25.
[0029] In the distribution curve of the first chemical elements 25,
a Ti peak 251 is shown at 458.8 eV and an O peak 252 is shown at
531.0 eV, together with a carbon (C) peak 253 and a fluorine (F)
peak 254.
[0030] Please refer to FIG. 2C and FIG. 2D, which are views showing
distribution curves of the second and the third elements of the
first preferred embodiment. As shown in the figures, distribution
curves of Ti element 261 and C element 262 in the TiO.sub.x film
onto polymer sheet are displayed. In the distribution curve of the
Ti element 261, a Ti 2p3/2 peak 2611 is shown at a power of 458.8
eV; and a Ti 2p1/2 peak 2612, at a power of 464 eV. In the
distribution curve of the C element 262, a C peak 2621 is shown at
a power of 284.5 eV; and a carbon fluoride (CF.sub.2) peak 2622, at
292 eV.
[0031] Please refer to FIG. 3, which is a view showing a flowchart
of a second preferred embodiment. As shown in the figure, a
hydrophilic polymer film used in a second preferred embodiment is a
stretchable Teflon having hydrophilic HMDSZ to obtain a TiO.sub.x
biomedical material onto polymer sheet according to the present
invention, comprising the following steps:
[0032] (a) Obtaining a stretchable Teflon having hydrophilic HMDSZ
to be coated with an organic Ti solution 31: A stretchable Teflon
having hydrophilic HMDSZ is obtained through a sol-gel method to be
coated with an organic Ti solution, where the sol-gel method
comprises steps of: (i) solving a precursor of TIP into an organic
solution; (ii) obtaining an organic Ti solution by using ultra
sonic waves and (iii) spin-coating the organic Ti solution on the
stretchable Teflon having hydrophilic HMDSZ.
[0033] (b) Processing a plasma activation treatment 32: An O.sub.2
having a pressure between 150 and 250 mtorr is accessed to the
stretchable Teflon coated with the organic Ti solution for
processing a plasma activation treatment under a 50 mtorr vacuum
pressure, where the working power is greater than 10 W and the
plasma activation treatment is processed for 15 min. Thus, a
TiO.sub.x film onto a stretchable Teflon is obtained.
[0034] Please refer to FIG. 3A, which is a view showing a
distribution curves of a first element of the second preferred
embodiment. As shown in the figure, a TiO.sub.x film onto polymer
sheet is processed through an electron spectroscopy for chemical
analysis to obtain a distribution curve of a second chemical
element 33. A Ti--O peak 331 is found at a power about 458.8 eV;
and an O peak 332, at about 531.0 eV; along with a C peak 333 and
an F peak 334.
[0035] Please refer to FIG. 3B and FIG. 3C, which are views showing
distribution curves of the second and the third elements of the
second preferred embodiment. As shown in the figures, distribution
curves of Ti element 34 and C element 35 in the TiO.sub.x film onto
polymer sheet are displayed. In the distribution curve of the Ti
element 34, a Ti 2p3/2 peak 341 is shown at a power of 458.8 eV;
and a Ti 2p1/2 peak 342, at a power of 464 eV. In the distribution
curve of the C element 35, a C peak 351 is shown at a power of
284.5 eV; and a CF.sub.2 peak 352, at 292 eV.
[0036] In FIG. 3B and FIG. 3C, two highest intensities are found in
the distribution curves for the Ti element 34 and the C element 35
separately. These two intensities are both smaller than those two
highest intensities found in the distribution curves for the Ti
element 261 and the C element 262 in FIG. 2C and FIG. 2D
respectively. In the process of the plasma activation treatment,
crystallization to the TiOR film happens on the surface of the
polymer film owing to the heat generated. As time goes by on
processing the plasma activation treatment, more crystallization
happens to the TiOR film and the intensity becomes higher.
[0037] Please refer to FIG. 4 and FIG. 4A, which are views showing
flow charts of a third preferred embodiment itself and its step
(c). As shown in the figures, the hydrophilic polymer film used in
the present invention is a stretchable Teflon having hydrophilic
HMDSZ and is made into a TiO.sub.x film on the stretch able Teflon
through the following steps:
[0038] (a) Obtaining a stretchable Teflon having hydrophilic HMDSZ
to be coated with an organic Ti solution 41: A stretchable Teflon
having hydrophilic HMDSZ is obtained through a sol-gel method to be
coated with an organic Ti solution, where the sol-gel method
comprises steps of: (i) solving a precursor of TIP into an organic
solution; (ii) obtaining an organic Ti solution by using ultra
sonic waves; and (iii) sp in coating the organic Ti solution on the
stretch able Teflon having hydrophilic HMDSZ.
[0039] (b) Processing a plasma activation treatment 42: An O.sub.2
having a pressure between 150 and 250 mtorr is accessed to the
stretchable Teflon coated with the organic Ti solution for
processing a plasma activation treatment under a 50 mtorr vacuum
pressure to obtain a TiO.sub.x film onto a stretchable Teflon,
where the working power is greater than 10 W.
[0040] (c) Processing a copolymerization in surface grafting 43:
The TiO.sub.x film onto a stretchable Teflon is processed with a
copolymerization in surface grafting, comprising the following
steps: [0041] (c1) Mixing NVP solution and vitamin B2 solution 431:
The TiO.sub.x film onto a stretchable Teflon is mixed into a
solution of N-Vinyl-2-pyrrolidinone (NVP) less than 30 weight
percents (wt %). The solution is then added with a certain amount
of vitamin B2 solution in a rate of 4:1 while being accessed with
nitrogen for 30 min. [0042] (c2) Irradiating by UV light 432: The
above mixed solution having the TiO.sub.x film onto a stretchable
Teflon is irradiated by an ultra-violet light for 5 to 30 min.
[0043] (c3) Taking out stretchable Teflon to be cleaned with
distilled water 433: The stretchable Teflon is taken out and is
cleaned with a distilled water for less than 40 hours to remove
homopolymer and unreacted monomer.
[0044] Please refer to FIG. 4B and FIG. 4C, which are a first and a
second views showing the water contact angle. As shown in the
figures, the plasma activation treatment in step (b) is processed
for 30 seconds (sec), 3 min, 5 min 10 min, 15 min, 30 min, 45 min
or 60 min. In addition to the plasma activation treatment together
with being irradiated with a UV light for 5 min to 30 min, a
various water contact angle is obtained for the various TiO.sub.x
film onto stretchable Teflon with a various time for plasma
activation treatment and a various time for UV irradiation.
[0045] In FIG. 4B, a first curve 44, a second curve 45, a third
curve 46, a fourth curve 47 and a fifth curve 48 are shown. The
first curve 44 shows a change in water contact angle after 30 sec
of plasma activation treatment together with 5 to 30 min of UV
light irradiation; the second curve 45, 3 min of plasma activation
treatment together with 5 to 30 min of UV light irradiation; the
third curve 46, 5 min of plasma activation treatment together with
5 to 30 min of UV light irradiation; the fourth curve 47, 10 min of
plasma activation treatment together with 5 to 30 min of UV light
irradiation; and the fifth curve 48, 15 min of plasma activation
treatment together with 5 to 30 min of UV light irradiation.
[0046] In FIG. 4C, a sixth curve 49, a seventh curve 50 and a
eighth curve 51 are shown. The sixth curve 49 shows a change in
water contact angle after 30 min of plasma activation treatment and
5 min to 30 min of UV light irradiation; the seventh curve 50, 45
min of plasma activation treatment together with 5 to 30 min of UV
light irradiation; and the eighth curve 51, 60 min of plasma
activation treatment together with 5 to 30 min of UV light
irradiation.
[0047] From the above two figures, it is found that, before
processing the plasma activation treatment, the stretchable Teflon
with the organic Ti solution has a water contact angle as high as
80 to 85 degrees (.degree.). After processing the plasma activation
treatment for a various time, the plasma is reacted with the
organic Ti solution on the surface of the stretchable Teflon, which
breaks a structure of a TIP precursor in the organic Ti solution so
that Ti containing peroxide is obtained on the surface of the
stretchable Teflon. D u ring the UV light irradiation, pairs of
electron and hole are increased and activated so that oxidation and
reduction to O.sub.2 and water molecules are accelerated to obtain
hydrophile on the surface. Take the seventh curve 50, for example.
After processing the UV light irradiation for 5 min and the plasma
activation treatment for 45 min, the water contact angle of the
TiO.sub.x film onto stretchable Teflon is reduced from 67.degree.
to 32.degree.. Take the eighth curve 51 as another example. The
plasma activation treatment is prolonged to 60 min; and the water
contact angle of the TiO.sub.x film onto stretchable Teflon is
increased from 56.degree. to 59.degree.. Yet, according to the
fourth curve 47, when the plasma activation treatment is shortened
to 10 min, the water contact angle of the TiO.sub.x film onto
stretchable Teflon is reduced from 77.degree. to 46.degree..
Therefore, the longer the plasma activation treatment is processed,
the better the Ti--O structure is formed on the surface of the
stretch able Teflon through the reaction with the organic Ti
solution.
[0048] Please refer to FIG. 4D, which is a view showing an
anti-bacterial effect. As shown in the figure, the TiO.sub.x film
on stretchable Teflon obtained in the third preferred embodiment is
processed through an anti-bacterial test by using pseudomonas
aeruginosa. And a best time duration for plasma activation
treatment 52 is obtained at 45 min for a best anti-bacterial
effect.
[0049] To sum up, the present invention is a plasma method for a
TiO.sub.x biomedical material onto polymer sheet, where, through a
simple procedure, a biomedical material having anti-bacterial
effect, hydrophile and good bio-compatibility is obtained.
[0050] The preferred embodiments herein disclosed are not intended
to unnecessarily limit the scope of the invention. Therefore,
simple modifications or variations belonging to the equivalent of
the scope of the claims and the instructions disclosed herein for a
patent are all within the scope of the present invention.
* * * * *