U.S. patent application number 11/642760 was filed with the patent office on 2007-11-15 for cosmetic method for soothing the reactions of discomfort of the scalp, using an oxyalkylenated sorbitan ester as a soothing agent.
Invention is credited to Sandrine Decoster, Patricia Mezure.
Application Number | 20070264219 11/642760 |
Document ID | / |
Family ID | 36973911 |
Filed Date | 2007-11-15 |
United States Patent
Application |
20070264219 |
Kind Code |
A1 |
Decoster; Sandrine ; et
al. |
November 15, 2007 |
Cosmetic method for soothing the reactions of discomfort of the
scalp, using an oxyalkylenated sorbitan ester as a soothing
agent
Abstract
The present disclosure relates to a cosmetic method for soothing
the reactions of discomfort of the scalp, wherein it comprises
applying on the scalp a cosmetic composition comprising, in an
aqueous or aqueous-alcoholic medium, at least one ester of fatty
acid and sorbitan comprising from 1 to 20 oxyalkylene units as a
soothing agent.
Inventors: |
Decoster; Sandrine; (Saint
Gratien, FR) ; Mezure; Patricia; (Bougival,
FR) |
Correspondence
Address: |
FINNEGAN, HENDERSON, FARABOW, GARRETT & DUNNER;LLP
901 NEW YORK AVENUE, NW
WASHINGTON
DC
20001-4413
US
|
Family ID: |
36973911 |
Appl. No.: |
11/642760 |
Filed: |
December 21, 2006 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
60757849 |
Jan 11, 2006 |
|
|
|
Current U.S.
Class: |
424/70.11 |
Current CPC
Class: |
A61K 8/4993 20130101;
A61K 2800/75 20130101; A61Q 5/006 20130101; A61Q 5/00 20130101;
A61Q 17/00 20130101; A61Q 5/02 20130101 |
Class at
Publication: |
424/070.11 |
International
Class: |
A61K 8/92 20060101
A61K008/92; A61Q 5/02 20060101 A61Q005/02; A61Q 5/12 20060101
A61Q005/12 |
Foreign Application Data
Date |
Code |
Application Number |
Dec 22, 2005 |
FR |
05 13192 |
Claims
1. A cosmetic method for soothing reactions of discomfort of the
scalp, comprising applying on the scalp as a soothing agent a
cosmetic composition comprising, in an aqueous or aqueous-alcoholic
medium, at least one ester of fatty acid and sorbitan comprising
from 1 to 20 oxyalkylene units.
2. A method according to claim 1, wherein the at least one
oxyalkylenated ester of fatty acid and sorbitan is
oxyethylenated.
3. A method according to claim 2, wherein the at least one ester of
fatty acid and sorbitan is chosen from oxyethylenated derivatives
of mono and polyesters of C.sub.8-30 fatty acids and sorbitan,
comprising from 1 to 20 ethylene oxide units.
4. A method according to claim 3, wherein the at least one ester of
fatty acid and sorbitan is chosen from oxyethylenated derivatives
of mono and polyesters of C.sub.12-24 fatty acids and sorbitan,
comprising from 4 to 20 ethylene oxide units.
5. A method according to claim 4, wherein the at least one ester of
fatty acid and sorbitan is chosen from oxyethylenated sorbitan
monolaurate with 4 OE, oxyethylenated sorbitan monolaurate with 20
OE, and mixtures thereof.
6. A method according to claim 5, wherein the at least one ester of
fatty acid and sorbitan is oxyethylenated sorbitan monolaurate with
4 OE.
7. A method according to claim 1, wherein the composition comprises
an aqueous medium.
8. A method according to claim 1, wherein the composition comprises
an aqueous-alcoholic medium comprising a mixture of water and at
least one cosmetically acceptable alcohol and/or at least one
cosmetically acceptable polyol.
9. A method according to claim 8, wherein the composition comprises
an aqueous-alcoholic medium comprising at least one polyol chosen
from glycerol, propylene glycol, polyethylene glycols and mixtures
thereof.
10. A method according to claim 8, wherein the composition
comprises an aqueous-alcoholic medium comprising at least one lower
C.sub.1-C.sub.4 alcohol.
11. A method according to claim 10, wherein the at least one lower
C.sub.1-C.sub.4 alcohol is chosen from ethanol, isopropanol,
tert-butanol, n-butanol and mixtures thereof.
12. A method according to claim 11, wherein the aqueous-alcoholic
medium comprises ethanol.
13. A method according to claim 8, wherein, in the
aqueous-alcoholic medium, the weight ratio of the water to the
alcohol(s) and polyol(s) ranges from 0.05 to 20.
14. A method according to claim 13, wherein the weight ratio of
water to alcohol(s) and polyol(s) ranges from 0.1 to 10.
15. A method according to claim 8, wherein the total content of
alcohol(s) and polyol(s) in the aqueous-alcoholic medium ranges
from 5 to 95 wt. %.
16. A method according to claim 15 wherein the total content of
alcohol(s) and polyol(s) in the aqueous alcoholic medium ranges
from 20 to 80 wt. %.
17. A method according to claim 1, wherein the cosmetic composition
is a shampoo or after-shampoo composition comprising, as a soothing
agent, said at least one ester of fatty acid and sorbitan
18. A method according to claim 17, wherein the shampoo or
after-shampoo composition is an anti-dandruff shampoo or an
anti-dandruff after-shampoo comprising, in addition to the
conventional ingredients of shampoos and after-shampoos, at least
one anti-dandruff agent.
19. A method according to claim 1, wherein the cosmetic composition
is an aqueous-alcholic lotion for treatment of the scalp,
comprising, as a soothing agent, said at least one ester of fatty
acid and sorbitan.
20. A method according to claim 19, wherein the aqueous-alcoholic
lotion comprises at least 80 wt. % of a mixture of water and
alcohol(s) and/or polyol(s).
21. A method according to claim 20, wherein the aqueous-alcoholic
lotion comprises at least 95 wt. % of a mixture of water and
alcohol(s) and/or polyol(s).
22. A method according to claim 1, wherein the cosmetic composition
is an anti-dandruff lotion comprising at least one anti-dandruff
agent and, as a soothing agent, at least one ester of fatty acid
and sorbitan.
23. A method according to claim 22, wherein the anti-dandruff agent
is chosen from piroctone olamine, zinc pyrithione, salicylic acid,
selenium disulphide and mixtures thereof.
24. A method according to claim 18, wherein the anti-dandruff
shampoo or the anti-dandruff after-shampoo comprises from 0.001 to
10 wt. % of anti-dandruff agent(s), relative to the total weight of
the composition.
25. A method according to claim 22, wherein the anti-dandruff
lotion comprises from 0.001 to 10 wt. % of anti-dandruff agent(s),
relative to the total weight of the composition.
26. A method according to claim 1, wherein the composition applied
to the scalp comprises at least 0.01 wt. % of the at least one
ester of fatty acid and sorbitan, relative to the total weight of
the composition.
27. A method according to claim 26, wherein the composition applied
to the scalp comprises from 0.05% to 10 wt. % of the at least one
ester of fatty acid and sorbitan relative to the total weight of
the composition.
28. A method according to claim 27, wherein the composition applied
to the scalp comprises from 0.2% to 5 wt. % of the at least one
ester of fatty acid and sorbitan relative to the total weight of
the composition.
29. A cosmetic method for soothing reactions of discomfort of the
scalp, comprising applying on the scalp an effective amount for
soothing of a cosmetic composition comprising, in an aqueous or
aqueous-alcoholic medium, at least one ester of fatty acid and
sorbitan comprising from 1 to 20 oxyalkylene units, and optionally
rinsing the scalp, optionally after a waiting time.
30. A method according to claim 29, which does not include a
rinsing stage.
31. A cosmetic method for soothing reactions of discomfort of the
scalp, comprising applying, on a dry or wet scalp, an effective
amount for soothing of a cosmetic composition comprising an
aqueous-alcoholic lotion comprising at least one oxyalkylenated
ester of fatty acid and sorbitan, and optionally rinsing the scalp
after a waiting time ranging from 30 s to 10 min.
Description
[0001] This application claims benefit of U.S. Provisional
Application No. 60/757,849 filed Jan. 11, 2006, the contents of
which are incorporated herein by reference. This application also
claims benefit of priority under 35 U.S.C. .sctn. 119 to French
Patent Application No. FR 05 13192, filed Dec. 22, 2005, the
contents of which are also incorporated herein by reference.
[0002] The present disclosure relates to the use of a particular
compound of the oxyalkylenated sorbitan ester family for soothing
the scalp.
[0003] Additionally, the present disclosure also relates to a
method of cosmetic treatment for soothing the scalp employing such
an oxyalkylenated sorbitan ester.
[0004] Many people have a scalp that is naturally sensitive, giving
rise to various effects of irritation and itching. Moreover, even a
scalp that is not very sensitive may be irritated by external
aggressive factors such as bad weather, sweat, frequent washing of
the hair, and the use of aggressive cosmetic hair products, for
example hair coloring or perming products, any of which may cause
itching on one or more areas of the scalp.
[0005] Application of compositions, generally aqueous-alcoholic, on
the scalp without rinsing is known as a remedy for this
discomfort.
[0006] Moreover, the use of oxyalkylenated sorbitan esters as
surfactants in compositions for cosmetic treatment of the hair has
been described in the prior art.
[0007] Thus, French Patent Application No. 2 804 020 describes mild
washing compositions, notably shampoos, comprising at least one
detergent surfactant and at least one oxyethylenated ester of fatty
acid and sorbitan having a number of moles of oxyethylene less than
or equal to 10. The use of such an ester of sorbitan in the
emulsifying system can lower the potential for irritation of the
eyes relative to a conventional shampoo containing only detergent
surfactants.
[0008] European Patent No. 1 430 867 describes an improved method
for the preparation of cationic nanoemulsions of the oil-in-water
type, intended for the cosmetic treatment of keratinous materials.
These nanoemulsions comprise at least one cationic surfactant, and
at least one nonionic surfactant. The nonionic surfactants that may
be used for the preparation of these nanoemulsions include, among
others, the mono-oleates of sorbitan with 4, with 5 or with 20
OE.
[0009] International Patent Application No. 2004/089318 describes,
for instance, compositions of shampoos offering improved detergent
and anti-dandruff action. These compositions contain:
[0010] (a) from 5 to 50 wt. % of a detergent surfactant,
[0011] (b) from 0.1 to 4 wt. % of an anti-dandruff agent,
[0012] (c) from 0.1 to 50 wt. % of a polyoxyethylenated derivative
of an ester of fatty acid and sorbitan, and
[0013] (d) at least 20 wt. % of water.
Compound (c) is derived from an ester of sorbitan and a
C.sub.14-C.sub.18 fatty acid such as palmitic, stearic, or oleic
acid. It is used as a surfactant.
[0014] European Patent Application No. 0 490 053 describes a hair
care composition in the form of a microemulsion comprising:
[0015] (a) from 5 to 20 wt. % of a nonionic surfactant with HLB
ranging from 5 to 12 or of a mixture of such surfactants, the HLB
of the mixture ranging from 6 to 10,
[0016] (b) from 5 to 20 wt. % of at least one oil,
[0017] (c) from 0.5 to 10 wt. % of at least one cationic
surfactant, and
[0018] (d) from 50 to 89.5 wt. % of water,
[0019] this composition not comprising a nonionic surfactant or
mixture thereof with of HLB greater than 12. Among the nonionic
surfactants that can be used in these microemulsions, non-limiting
mention may be made of the oxyethylenated esters of
C.sub.12-C.sub.18 fatty acids and of sorbitan comprising from 1 to
6 OE.
[0020] Thus, oxyalkylenated sorbitan esters have been used, in the
hairdressing compositions described in the prior art, as
surfactants or emulsifiers.
[0021] The present inventors have now discovered, surprisingly,
that the use, in an aqueous or aqueous-alcoholic medium, of certain
oxyalkylenated esters of fatty acids and sorbitan provides very
effective soothing of the scalp, i.e., prevents the appearance of
reactions of discomfort, lessens the intensity of these reactions,
or even causes them to disappear.
[0022] In at least one embodiment, these esters can be used for
preparing lotions or other hair care products that are effective
against reactions of discomfort of the scalp, such as irritation,
itching, tingling, and erythema.
[0023] The present disclosure therefore relates, in at least one
embodiment, to a cosmetic method for soothing the reactions of
discomfort of the scalp comprising applying on the scalp a cosmetic
composition comprising, in an aqueous or aqueous-alcoholic medium,
at least one ester of fatty acid and sorbitan comprising from 1 to
20 oxyalkylene units as a soothing agent.
[0024] Additionally, the present disclosure also relates to a
method of preparation of an aqueous or aqueous-alcoholic cosmetic
composition intended for soothing the reactions of discomfort of
the scalp, comprising incorporating in said composition at least
one ester of fatty acid and sorbitan comprising from 1 to 20
oxyalkylene units as a soothing agent.
[0025] The present disclosure further relates to a method of
cosmetic treatment of the reactions of discomfort of the scalp,
comprising applying on the scalp a cosmetic composition comprising,
in an aqueous or aqueous-alcoholic medium, a soothing agent
comprising at least one ester of fatty acid and sorbitan comprising
from 1 to 20 oxyalkylene units.
[0026] As used in the present disclosure, the phrase "soothing the
reactions of discomfort of the scalp" is understood to mean
preventing the development of at least one reaction of discomfort
of the scalp, such as hotness, itching, tingling, erythema,
irritation, as well as reducing the intensity of such a reaction,
or even eliminating it, when the latter is already present on the
scalp.
[0027] Other objects and characteristics, aspects and advantages of
the disclosure will become clearer on reading the description and
the examples given below.
[0028] As used herein, "compound with X OE" is understood to mean
an oxyethylenated compound comprising X oxyethylene units per
molecule.
[0029] Furthermore, as used in the present disclosure, "CY
compound" is understood to mean a compound comprising Y carbon
atoms.
[0030] Non-limiting examples of the compounds that can be used in
the present disclosure are esters of fatty acid and sorbitan
comprising from 1 to 20 oxyalkylene units. The oxyalkylene units
can, for example, be chosen from oxyethylene and oxypropylene
units, and, in at least one embodiment, are oxyethylene units.
[0031] In at least one embodiment, oxyethylenated derivatives of
mono and polyesters of C.sub.8-30 fatty acids and sorbitan having
from 1 to 20 ethylene oxide units are used. In a further
embodiment, oxyethylenated derivatives of mono and polyesters of
C.sub.12-24 fatty acids and sorbitan having from 4 to 20 ethylene
oxide units are used.
[0032] Such compounds are also called polysorbates. Among others,
they are marketed under the designation TWEEN by the company
UNIQEMA. Non-limiting examples can be made of the following: the
oxyethylenated sorbitan monolaurate with 4 OE, marketed under the
designation TWEEN 21, the oxyethylenated sorbitan monolaurate with
20 OE, marketed under the designation TWEEN 20, the oxyethylenated
sorbitan monopalmitate with 20 OE marketed under the designation
TWEEN 40, the oxyethylenated sorbitan monostearate with 20 OE
marketed under the designation TWEEN 60, the oxyethylenated
sorbitan monostearate with 4 OE marketed under the designation
TWEEN 61, the oxyethylenated sorbitan tristearate with 20 OE
marketed under the designation TWEEN 65, the oxyethylenated
sorbitan monooleate with 20 OE marketed under the designation TWEEN
80, the oxyethylenated sorbitan monooleate with 5 OE marketed under
the designation TWEEN 81, and the oxyethylenated sorbitan trioleate
with 20 OE marketed under the designation TWEEN 85.
[0033] The fatty acid of the oxyalkylenated sorbitan ester can be,
for example, a saturated fatty acid.
[0034] In at least one embodiment, the sorbitan esters used herein
are the oxyethylenated sorbitan monolaurate with 4 OE, the
oxyethylenated sorbitan monolaurate with 20 OE, and mixtures
thereof. In at least one further embodiment, the sorbitan ester is
the oxyethylenated sorbitan monolaurate with 4 OE.
[0035] According to the present disclosure, the oxyalkylenated
ester of fatty acid and sorbitan can be employed in an aqueous
medium, or in an aqueous-alcoholic medium.
[0036] As used in the present disclosure, the term "aqueous medium"
is understood to mean a medium comprising at least 50 wt. % of
water.
[0037] As used in the present disclosure, the term
"aqueous-alcoholic medium" is understood to mean a medium
comprising a mixture of water and at least one cosmetically
acceptable alcohol and/or at least one cosmetically acceptable
polyol.
[0038] The aqueous-alcoholic medium can thus comprise at least one
polyol chosen from glycerol, propylene glycol, polyethylene glycols
and mixtures thereof.
[0039] In at least one embodiment of the present disclosure, the
aqueous-alcoholic medium comprises at least one C.sub.1-C.sub.4
lower alcohol, for example ethanol, isopropanol, tert-butanol,
n-butanol and mixtures thereof. In at least one further embodiment,
the aqueous-alcoholic medium comprises ethanol.
[0040] It is also possible to use, within the scope of the present
disclosure, a mixture of alcohol(s) and of polyol(s) as described
above.
[0041] The weight ratio of water to alcohol(s) and polyol(s), in
the aqueous-alcoholic medium, can, for example, range from 0.05 to
20. For instance, this ratio can range from 0.1 to 10, such as from
0.25 to 4, and further, for example, from 0.5 to 2.
[0042] The total content of alcohol(s) and polyol(s) in the
aqueous-alcoholic medium can range from 5 to 95 wt. %, for example
from 10 to 90 wt. %, further for example from 20 to 80 wt. %, and
even further for example from 20 to 70 wt. %.
[0043] According to the present disclosure, the oxyalkylenated
ester of fatty acid and sorbitan can be applied to the scalp in an
aqueous composition, i.e., a composition comprising at least 50 wt.
% of water, or in an aqueous-alcoholic composition, i.e., a
composition comprising at least 50 wt. % of the aforementioned
mixture of water and of alcohol(s) and/or polyol(s).
[0044] For this purpose, the oxyalkylenated ester of fatty acid and
sorbitan can be incorporated as a soothing agent in any hair
treatment composition that comprises water and/or at least one
alcohol and/or at least one polyol.
[0045] For example, the oxyalkylenated ester of the fatty acid and
sorbitan can thus be added as a soothing agent to conventional hair
care compositions, such as compositions for washing the hair and
the scalp, compositions for coloring, bleaching, perming or
straightening of the hair, compositions for shaping the hair such
as lacquers, gels, mousses, compositions for cosmetic treatment of
the scalp such as anti-dandruff treatments, treatments against hair
loss, moisturizing treatments, nourishing treatments, and soothing
treatments.
[0046] Thus, the oxyalkylenated ester of fatty acid and sorbitan
can be added, for example, to a shampoo or after-shampoo
composition.
[0047] Shampoo and after-shampoo compositions are familiar to a
person skilled in the art. Shampoos conventionally comprise a
washing base comprising at least one surfactant chosen from
anionic, nonionic, amphoteric and zwitterionic surfactants. The
after-shampoos conventionally comprise at least one conditioner,
for example cationic surfactants, cationic polymers, amphoteric or
zwitterionic polymers, or silicones. The shampoos can also comprise
such conditioners.
[0048] The shampoos and after-shampoos can also comprise,
non-exhaustively, at least one fat, for example vegetable oils,
animal oils, mineral oils, natural or synthetic oils, waxes, and
aliphatic alcohols, at least one conventional additive such as
agents against hair loss, oxidants, ceramides and pseudo-ceramides,
vitamins and pro-vitamins including panthenol, ceramides and
pseudo-ceramides, sun filters, mineral or organic, colored or
colorless pigments, dyes, lustre agents and opacifiers,
sequestering agents, plasticizers, solubilizers, acidifiers,
alkalizing agents, mineral or organic thickeners, antioxidants,
hydroxy acids, perfumes and preservatives.
[0049] The oxyalkylenated ester of fatty acid and sorbitan can also
be added to anti-dandruff compositions such as anti-dandruff
shampoos, and anti-dandruff after-shampoos.
[0050] The anti-dandruff shampoos and after-shampoos comprise, in
addition to the conventional ingredients of shampoos and
after-shampoos, at least one anti-dandruff agent. The following are
non-limiting examples of compounds that can be used as
anti-dandruff agents: piroctone olamine, zinc pyrithione, salicylic
acid, selenium disulphide, and mixtures thereof.
[0051] The compositions of anti-dandruff shampoos and
after-shampoos comprise, in at least one embodiment, from 0.001 to
10 wt. % of anti-dandruff agent(s), for example, from 0.1 to 5 wt.
%, further, for example, from 0.2 to 2 wt. %, relative to the total
weight of the composition.
[0052] According to another embodiment of the present disclosure,
the oxyalkylenated ester of fatty acid and sorbitan is incorporated
in an aqueous-alcoholic lotion for cosmetic treatment of the
scalp.
[0053] As used herein, the term "aqueous-alcoholic lotion" is
understood to mean a lotion comprising at least 80 wt. %, for
example at least 90 wt. %, and further for example at least 95 wt.
% of a mixture of water and at least one alcohol and/or polyol as
described above. It can be a conventional lotion, or an
anti-dandruff lotion, i.e., a lotion comprising at least one
anti-dandruff agent such as those described above.
[0054] Such an anti-dandruff lotion comprises, in at least one
embodiment, from 0.001 to 10 wt. % of anti-dandruff agent(s), for
example from 0.01 to 5 wt. %, and further for example from 0.02 to
2 wt. %, relative to the total weight of the composition.
[0055] According to at least one embodiment of the present
disclosure, the composition applied to the scalp comprises at least
0.01 wt. % of oxyalkylenated ester of fatty acid and sorbitan,
relative to the total weight of the composition. For instance, the
composition can comprise from 0.05 wt. % to 10 wt. % of
oxyalkylenated ester of fatty acid and sorbitan, further for
example from 0.1 to 8 wt. %, and even further for example, from 0.2
to 5 wt. %, relative to the total weight of the composition.
[0056] The present disclosure also relates to a method of cosmetic
treatment intended for soothing reactions of discomfort of the
scalp, comprising applying, on the scalp, an effective amount of a
cosmetic composition as described above and which comprises, in an
aqueous or aqueous-alcoholic medium, as a soothing agent, at least
one oxyalkylenated ester of fatty acid and sorbitan as described
herein.
[0057] According to at least one embodiment of the present
disclosure, such a method comprises applying, on the scalp, an
effective amount of the cosmetic composition, then optionally
rinsing, optionally after a waiting time.
[0058] The method according to the present disclosure can be
employed with or without rinsing. In at least one embodiment, it is
employed without rinsing, i.e., it does not include a rinsing
stage.
[0059] In yet another embodiment of the present disclosure, the
method comprises applying an effective amount of an
aqueous-alcoholic lotion comprising at least one oxyalkylenated
ester of fatty acid and sorbitan as described above, to the scalp
when dry or wet. The product is then optionally rinsed, after a
waiting time ranging from 30 s to 10 min.
[0060] Other than in the operating examples, or where otherwise
indicated, all numbers expressing quantities of ingredients,
reaction conditions, and so forth used in the specification and
claims are to be understood as being modified in all instances by
the term "about." Accordingly, unless indicated to the contrary,
the numerical parameters set forth in the following specification
and attached claims are approximations that may vary depending upon
the desired properties sought to be obtained by the present
disclosure. At the very least, and not as an attempt to limit the
application of the doctrine of equivalents to the scope of the
claims, each numerical parameter should be construed in light of
the number of significant digits and ordinary rounding
approaches.
[0061] Notwithstanding that the numerical ranges and parameters
setting forth the broad scope of the disclosure are approximations,
the numerical values set forth in the specific examples are
reported as precisely as possible. Any numerical value, however,
inherently contain certain errors necessarily resulting from the
standard deviation found in their respective testing
measurements.
[0062] The following examples are intended to illustrate the
present disclosure in a non-limiting manner.
EXAMPLE
[0063] In the following comparative example, all the amounts are
given as percentage by weight of active substance, relative to the
total weight of the composition, unless stated otherwise.
[0064] A lotion A, according to the present disclosure, and a
comparative lotion B were prepared from the ingredients shown in
the following table. TABLE-US-00001 Composition Lotion A Lotion B
oxyethylenated sorbitan monolaurate 0.5 0 with 4 OE (TWEEN 21 from
Uniqema) ethoxylated castor oil (CREMOPHOR 0.3 0.3 RH 40 from BASF)
ethanol 40.6 40.6 water qsf 100% 100%
[0065] A test of efficacy of the soothing effect of lotions A and B
with respect to an irritant (capsaicin) was carried out, as
follows:
[0066] Lotions A and B were each applied on a small area of the
scalp (the hair having been shaved from the areas of application)
of 29 subjects with sensitive scalps.
[0067] Then a cream comprising 0.025 wt. % of capsaicin was applied
to the two application areas of each subject.
[0068] The reactions of discomfort of the scalp (hotness, itching,
tingling and erythema) were evaluated before each application of
product on the scalp, then 10 minutes after the waiting time for
each lotion, then at different waiting times for the cream based on
capsaicin.
[0069] The sensations of hotness, itching and tingling were each
assessed and noted by each subject, on an increasing scale (with
the score increasing as the sensation felt increases). Development
of erythema was observed and noted (also on an increasing scale),
for each subject, by the experimenter.
[0070] The reactions of discomfort obtained with lotion A on one
hand, and with lotion B on the other hand, were analysed
statistically (mean value for each reaction of discomfort, and for
the cumulative discomfort: hotness+itching+tingling+erythema).
[0071] The following results were obtained:
[0072] regarding the reactions of erythema, the mean value obtained
was 4.3 for lotion A, and 6.7 for lotion B, with a value of p of
0.005.
[0073] regarding the cumulative discomfort, the mean value obtained
was 10 for lotion A, and 14.1 for lotion B, with a value of p of
0.020.
Thus, application of lotion A according to the present disclosure
on the scalp was found to provide a soothing effect far greater
than that obtained by application of comparative lotion B.
[0074] In particular, a significant decrease in reactions of
erythema, as well as cumulative discomfort, was observed.
* * * * *