U.S. patent application number 11/507097 was filed with the patent office on 2007-05-03 for corynebacterium glutamicum genes encoding novel proteins.
This patent application is currently assigned to BASF AG. Invention is credited to Gregor Haberhauer, Burkhard Kroger, Markus Pompejus, Hartwig Schroder, Oskar Zelder.
Application Number | 20070099213 11/507097 |
Document ID | / |
Family ID | 35206960 |
Filed Date | 2007-05-03 |
United States Patent
Application |
20070099213 |
Kind Code |
A1 |
Pompejus; Markus ; et
al. |
May 3, 2007 |
Corynebacterium glutamicum genes encoding novel proteins
Abstract
Isolated nucleic acid molecules, designated MCP nucleic acid
molecules, which encode novel MCP proteins from Corynebacterium
glutamicum are described. The invention also provides antisense
nucleic acid molecules, recombinant expression vectors containing
MCP nucleic acid molecules, and host cells into which the
expression vectors have been introduced. The invention still
further provides isolated MCP proteins, mutated MCP proteins,
fusion proteins, antigenic peptides and methods for the improvement
of production of a desired compound from C. glutamicum based on
genetic engineering of MCP genes in this organism.
Inventors: |
Pompejus; Markus;
(Freinsheim, DE) ; Kroger; Burkhard; (Limbugerhof,
DE) ; Schroder; Hartwig; (Nussloch, DE) ;
Zelder; Oskar; (Speyer, DE) ; Haberhauer; Gregor;
(Limburgerhof, DE) |
Correspondence
Address: |
LAHIVE & COCKFIELD
28 STATE STREET
BOSTON
MA
02109
US
|
Assignee: |
BASF AG
Ludwigshafen
DE
|
Family ID: |
35206960 |
Appl. No.: |
11/507097 |
Filed: |
August 17, 2006 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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11092052 |
Mar 28, 2005 |
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11507097 |
Aug 17, 2006 |
|
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09605703 |
Jun 27, 2000 |
6962989 |
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11092052 |
Mar 28, 2005 |
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60142764 |
Jul 8, 1999 |
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60152318 |
Sep 3, 1999 |
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Current U.S.
Class: |
435/6.15 ;
435/106; 435/193; 435/252.3; 435/471; 435/69.1; 536/23.2 |
Current CPC
Class: |
C07H 21/02 20130101;
C12P 13/222 20130101; C12P 13/24 20130101; C12P 13/14 20130101;
C12P 13/12 20130101; C12P 13/225 20130101; C12P 13/10 20130101;
C07K 14/34 20130101; C12P 13/04 20130101; C12P 13/20 20130101; C07H
21/04 20130101; C12P 13/227 20130101; C12P 13/06 20130101; C12P
13/08 20130101 |
Class at
Publication: |
435/006 ;
536/023.2; 435/069.1; 435/106; 435/193; 435/252.3; 435/471 |
International
Class: |
C12Q 1/68 20060101
C12Q001/68; C07H 21/04 20060101 C07H021/04; C12P 21/06 20060101
C12P021/06; C12P 13/04 20060101 C12P013/04; C12N 9/10 20060101
C12N009/10; C12N 1/21 20060101 C12N001/21; C12N 15/74 20060101
C12N015/74 |
Claims
1. An isolated nucleic acid molecule selected from the group
consisting of a) an isolated nucleic acid molecule comprising the
nucleotide sequence of SEQ ID NO:2693, or a complement thereof; b)
an isolated nucleic acid molecule which encodes a polypeptide
comprising the amino acid sequence of SEQ ID NO:2694, or a
complement thereof; c) an isolated nucleic acid molecule which
encodes a naturally occurring allelic variant of a polypeptide
comprising the amino acid sequence of SEQ ID NO:2694, or a
complement thereof; d) an isolated nucleic acid molecule comprising
a nucleotide sequence which is at least 50% identical to the entire
nucleotide sequence of SEQ ID NO:2693, or a complement thereof; and
e) an isolated nucleic acid molecule comprising a fragment of at
least 15 contiguous nucleotides of the nucleotide sequence of SEQ
ID NO:2693, or a complement thereof.
2. An isolated nucleic acid molecule comprising the nucleic acid
molecule of claim 1 and a nucleotide sequence encoding a
heterologous polypeptide.
3. A vector comprising the nucleic acid molecule of claim 1.
4. The vector of claim 3, which is an expression vector.
5. A host cell transfected with the expression vector of claim
4.
6. The host cell of claim 5, wherein said cell is a
microorganism.
7. The host cell of claim 6, wherein said cell belongs to the genus
Corynebacterium or Brevibacterium.
8. A method of producing a polypeptide comprising culturing the
host cell of claim 5 in an appropriate culture medium to, thereby,
produce the polypeptide.
9. A method for producing a fine chemical, comprising culturing the
cell of claim 5 such that the fine chemical is produced.
10. The method of claim 9, wherein said method further comprises
the step of recovering the fine chemical from said culture.
11. The method of claim 9, wherein said cell belongs to the genus
Corynebacterium or Brevibacterium.
12. The method of claim 9, wherein said cell is selected from the
group consisting of Corynebacterium glutamicum, Corynebacterium
herculis, Corynebacterium, lilium, Corynebacterium
acetoacidophilum, Corynebacterium acetoglutamicum, Corynebacterium
acetophilum, Corynebacterium ammoniagenes, Corynebacterium
fujiokense, Corynebacterium nitrilophilus, Brevibacterium
ammoniagenes, Brevibacterium butanicum, Brevibacterium divaricatum,
Brevibacterium flavum, Brevibacterium healii, Brevibacterium
ketoglutamicum, Brevibacterium ketosoreductum, Brevibacterium
lactofermentum, Brevibacterium linens, Brevibacterium
paraffinolyticum, and those strains set forth in Table 3.
13. The method of claim 9, wherein expression of the nucleic acid
molecule from said vector results in modulation of production of
said fine chemical.
14. The method of claim 9, wherein said fine chemical is selected
from the group consisting of organic acids, proteinogenic and
nonproteinogenic amino acids, purine and pyrimidine bases,
nucleosides, nucleotides, lipids, saturated and unsaturated fatty
acids, diols, carbohydrates, aromatic compounds, vitamins,
cofactors, polyketides, and enzymes.
15. The method of claim 9, wherein said fine chemical is an amino
acid selected from the group consisting of lysine, glutamate,
glutamine, alanine, aspartate, glycine, serine, threonine,
methionine, cysteine, valine, leucine, isoleucine, arginine,
proline, histidine, tyrosine, phenylalanine, and tryptophan.
16. An isolated polypeptide selected from the group consisting of
a) an isolated polypeptide comprising the amino acid sequence of
SEQ ID NO:2694; b) an isolated polypeptide comprising a naturally
occurring allelic variant of a polypeptide comprising the amino
acid sequence of SEQ ID NO:2694; c) an isolated polypeptide which
is encoded by a nucleic acid molecule comprising the nucleotide
sequence of SEQ ID NO:2693; d) an isolated polypeptide which is
encoded by a nucleic acid molecule comprising a nucleotide sequence
which is at least 50% identical to the entire nucleotide sequence
of SEQ ID NO:2693; e) an isolated polypeptide comprising an amino
acid sequence which is at least 50% identical to the entire amino
acid sequence of SEQ ID NO:2694; and f) an isolated polypeptide
comprising a fragment of a polypeptide comprising the amino acid
sequence of SEQ ID NO:2694, wherein said polypeptide fragment
maintains a biological activity of the polypeptide comprising the
amino sequence.
17. The isolated polypeptide of claim 16, further comprising
heterologous amino acid sequences.
18. A method for diagnosing the presence or activity of
Corynebacterium diphtheriae in a subject, comprising detecting the
presence of at least one of the nucleic acid molecules of claim 1,
thereby diagnosing the presence or activity of Corynebacterium
diphtheriae in the subject.
19. A method for diagnosing the presence or activity of
Corynebacterium diphtheriae in a subject, comprising detecting the
presence of at least one of the polypeptide molecules of claim 16,
thereby diagnosing the presence or activity of Corynebacterium
diphtheriae in the subject.
20. A host cell comprising a nucleic acid molecule selected from
the group consisting of a) the nucleic acid molecule of SEQ ID
NO:2693, wherein the nucleic acid molecule is disrupted by at least
one technique selected from the group consisting of a point
mutation, a truncation, an inversion, a deletion, an addition, a
substitution and homologous recombination; b) the nucleic acid
molecule of SEQ ID NO:2693, wherein the nucleic acid molecule
comprises one or more nucleic acid modifications as compared to the
sequence of SEQ ID NO:2693, wherein the modification is selected
from the group consisting of a point mutation, a truncation, an
inversion, a deletion, an addition and a substitution; and c) the
nucleic acid molecule of SEQ ID NO:2693, wherein the regulatory
region of the nucleic acid molecule is modified relative to the
wild-type regulatory region of the molecule by at least one
technique selected from the group consisting of a point mutation, a
truncation, an inversion, a deletion, an addition, a substitution
and homologous recombination.
Description
RELATED APPLICATIONS
[0001] This application is a divisional of U.S. application Ser.
No. 11/092,052, filed Mar. 28, 2005, which is a continuation of
U.S. application Ser. No. 09/605,703, filed Jun. 27, 2000, now U.S.
Pat. No. 6,962,989, issued Nov. 8, 2005, which, in turn, claims
priority to prior filed U.S. Provisional Patent Application Ser.
No. 60/142,764, filed Jul. 8, 1999, and U.S. Provisional Patent
Application Ser. No. 60/152,318, filed Sep. 3, 1999. The entire
contents of both of the aforementioned applications are hereby
expressly incorporated herein by reference.
BACKGROUND OF THE INVENTION
[0002] Certain products and by-products of naturally-occurring
metabolic processes in cells have utility in a wide array of
industries, including the food, feed, cosmetics, and pharmaceutical
industries. These molecules, collectively termed `fine chemicals`,
include organic acids, both proteinogenic and non-proteinogenic
amino acids, nucleotides and nucleosides, lipids and fatty acids,
diols, carbohydrates, aromatic compounds, vitamins and cofactors,
and enzymes. Their production is most conveniently performed
through the large-scale culture of bacteria developed to produce
and secrete large quantities of one or more desired molecules. One
particularly useful organism for this purpose is Corynebacterium
glutamicum, a gram positive, nonpathogenic bacterium. Through
strain selection, a number of mutant strains have been developed
which produce an array of desirable compounds. However, selection
of strains improved for the production of a particular molecule is
a time-consuming and difficult process.
INCORPORATION OF MATERIAL SUBMITTED ON COMPACT DISCS
[0003] This application incorporates herein by reference the
material contained on the compact discs submitted herewith as part
of this application. Specifically, the file "seqlistcorrected"
(8.19 MB) contained on each of Copy 1, Copy 2 and the CRF copy of
the Sequence Listing is hereby incorporated herein by reference.
This file was created on Jul. 31, 2006. In addition, the files
"Appendix A" (1.33 MB) and "Appendix B" (478 KB) contained on each
of the compact disks entitled "Appendices Copy I" and "Appendices
Copy 2" are hereby incorporated herein by reference. Each of these
files were created on Jul. 31, 2006.
SUMMARY OF THE INVENTION
[0004] The invention provides novel bacterial nucleic acid
molecules which have a variety of uses. These uses include the
identification of microorganisms which can be used to produce fine
chemicals, the modulation of fine chemical production in C.
glutamicum or related bacteria, the typing or identification of C.
glutamicum or related bacteria, as reference points for mapping the
C. glutamicum genome, and as markers for transformation. These
novel nucleic acid molecules encode proteins, referred to herein as
marker and fine chemical production (MCP) proteins.
[0005] C. glutamicum is a gram positive, aerobic bacterium which is
commonly used in industry for the large-scale production of a
variety of fine chemicals, and also for the degradation of
hydrocarbons (such as in petroleum spills) and for the oxidation of
terpenoids. The MCP nucleic acid molecules of the invention,
therefore, can be used to identify microorganisms which can be used
to produce fine chemicals, e.g., by fermentation processes.
Modulation of the expression of the MCP nucleic acids of the
invention, or modification of the sequence of the MCP nucleic acid
molecules of the invention, can be used to modulate the production
of one or more fine chemicals from a microorganism (e.g., to
improve the yield or production of one or more fine chemicals from
a Corynebacterium or Brevibacterium species).
[0006] The MCP nucleic acids of the invention may also be used to
identify an organism as being Corynebacterium glutamicum or a close
relative thereof, or to identify the presence of C. glutamicum or a
relative thereof in a mixed population of microorganisms. The
invention provides the nucleic acid sequences of a number of C.
glutamicum genes; by probing the extracted genomic DNA of a culture
of a unique or mixed population of microorganisms under stringent
conditions with a probe spanning a region of a C. glutamicum gene
which is unique to this organism, one can ascertain whether this
organism is present. Although Corynebacterium glutamicum itself is
nonpathogenic, it is related to species pathogenic in humans, such
as Corynebacterium diphtheriae (the causative agent of diphtheria);
the detection of such organisms is of significant clinical
relevance.
[0007] The MCP nucleic acid molecules of the invention may also
serve as reference points for mapping of the C. glutamicum genome,
or of genomes of related organisms. Similarly, these molecules, or
variants or portions thereof, may serve as markers for genetically
engineered Corynebacterium or Brevibacterium species.
[0008] The MCP proteins encoded by the novel nucleic acid molecules
of the invention may be involved, for example, in the direct or
indirect production of one or more fine chemicals from C.
glutamicum. The MCP proteins of the invention may also participate
in the degradation of hydrocarbons or the oxidation of terpenoids.
These proteins may also be utilized for the identification of
Corynebacterium glutamicum or organisms related to C. glutamicum;
the presence of an MCP protein specific to C. glutamicum and
related species in a mixture of proteins may indicate the presence
of one of these bacteria in the sample. Further, these MCP proteins
may have homologues in plants or animals which are involved in a
disease state or condition; these proteins thus may serve as useful
pharmaceutical targets for drug screening and the development of
therapeutic compounds.
[0009] Given the availability of cloning vectors for use in
Corynebacterium glutamicum, such as those disclosed in Sinskey et
al., U.S. Pat. No. 4,649,119, and techniques for genetic
manipulation of C. glutamicum and the related Brevibacterium
species (e.g., lactofermentum) (Yoshihama et al, J. Bacteriol. 162:
591-597 (1985); Katsumata et al., J. Bacteriol. 159: 306-311
(1984); and Santamaria et al., J. Gen. Microbiol. 130: 2237-2246
(1984)), the nucleic acid molecules of the invention may be
utilized in the genetic engineering of this organism to modulate
the production of one or more fine chemicals. This modulation may
be due to a direct effect of manipulation of a gene of the
invention, or it may be due to an indirect effect of such
manipulation. For example, by modifying the activity of a protein
involved in the biosynthesis or degradation of a fine chemical
(i.e., through mutagenesis of the corresponding gene), one may
directly modulate the ability of the cell to synthesize or to
degrade this compound, thereby modulating the yield and/or
efficiency of production of the fine chemical. Similarly, by
modulating the activity of a protein which regulates a fine
chemical metabolic pathway, one may directly influence whether the
production of the desired compound is up- or down-regulated, either
of which will modulate the yield or efficiency of production of the
fine chemical from the cell.
[0010] Indirect modulation of fine chemical production may also
result by modifying the activity of a protein of the invention
(i.e., by mutagenesis of the corresponding gene) such that the
overall ability of the cell to grow and divide or to remain viable
and productive is increased. The production of fine chemicals from
C. glutamicum is generally accomplished by the large-scale
fermentative culture of these microorganisms, conditions which are
frequently suboptimal for growth and cell division. By engineering
a protein of the invention (e.g., a stress response protein, a cell
wall protein, or proteins involved in the metabolism of compounds
necessary for cell growth and division to occur, such as
nucleotides and amino acids) such that it is better able to
survive, grow, and multiply in such conditions, it may be possible
to increase the number and productivity of such engineered C.
glutamicum cells in large-scale culture, which in turn should
result in increased yields and/or efficiency of production of one
or more desired fine chemicals. Further, the metabolic pathways of
any cell are necessarily interrelated and coregulated. By altering
the activity or regulation of any one metabolic pathway in C.
glutamicum (i.e., by altering the activity of one of the proteins
of the invention which participates in such a pathway), it is
possible to concomitantly alter the activity or regulation of other
metabolic pathways in this microorganism, which may be directly
involved in the synthesis or degradation of a fine chemical.
[0011] The invention provides novel nucleic acid molecules which
encode proteins, referred to herein as MCP proteins, which are
capable of, for example, modulating the production or efficiency of
production of one or more fine chemicals from C. glutamicum, or of
serving as identifying markers for C. glutamicum or related
organisms. Nucleic acid molecules encoding an MCP protein are
referred to herein as MCP nucleic acid molecules. In a preferred
embodiment, the MCP protein is capable of modulating the production
or efficiency of production of one or more fine chemicals from C.
glutamicum, or of serving as identifying markers for C. glutamicum
or related organisms. Examples of such proteins include those
encoded by the genes set forth in Table 1.
[0012] Accordingly, one aspect of the invention pertains to
isolated nucleic acid molecules (e.g., cDNAs, DNAs, or RNAs)
comprising a nucleotide sequence encoding an MCP protein or
biologically active portions thereof, as well as nucleic acid
fragments suitable as primers or hybridization probes for the
detection or amplification of MCP-encoding nucleic acid (e.g., DNA
or mRNA). In particularly preferred embodiments, the isolated
nucleic acid molecule comprises one of the nucleotide sequences set
forth in Appendix A or the coding region or a complement thereof of
one of these nucleotide sequences. In other particularly preferred
embodiments, the isolated nucleic acid molecule of the invention
comprises a nucleotide sequence which hybridizes to or is at least
about 50%, preferably at least about 60%, more preferably at least
about 70%, 80% or 90%, and even more preferably at least about 95%,
96%, 97%, 98%, 99% or more homologous to a nucleotide sequence set
forth in Appendix A, or a portion thereof. In other preferred
embodiments, the isolated nucleic acid molecule encodes one of the
amino acid sequences set forth in Appendix B. The preferred MCP
proteins of the present invention also preferably possess at least
one of the MCP activities described herein.
[0013] In another embodiment, the isolated nucleic acid molecule
encodes a protein or portion thereof wherein the protein or portion
thereof includes an amino acid sequence which is sufficiently
homologous to an amino acid sequence of Appendix B, e.g.,
sufficiently homologous to an amino acid sequence of Appendix B
such that the protein or portion thereof maintains an MCP activity.
Preferably, the protein or portion thereof encoded by the nucleic
acid molecule maintains the ability to modulate the production or
efficiency of production of one or more fine chemicals from C.
glutamicum, or of serving as an identifying marker for C.
glutamicum or related organisms. In one embodiment, the protein
encoded by the nucleic acid molecule is at least about 50%,
preferably at least about 60%, and more preferably at least about
70%, 80%, or 90% and most preferably at least about 95%, 96%, 97%,
98%, or 99% or more homologous to an amino acid sequence of
Appendix B (e.g., an entire amino acid sequence selected from those
sequences set forth in Appendix B). In another preferred
embodiment, the protein is a full length C. glutamicum protein
which is substantially homologous to an entire amino acid sequence
of Appendix B (encoded by an open reading frame shown in Appendix
A).
[0014] In another preferred embodiment, the isolated nucleic acid
molecule is derived from C. glutamicum and encodes a protein (e.g.,
an MCP fusion protein) which includes a biologically active domain
which is at least about 50% or more homologous to one of the amino
acid sequences of Appendix B and is able to modulate the yield,
production, and/or efficiency of production of one or more fine
chemicals from C. glutamicum, to degrade hydrocarbons, to oxidize
terpenoids, to serve as a target for drug development, or to serve
as an identifying marker for C. glutamicum or related organisms,
and which also includes heterologous nucleic acid sequences
encoding a heterologous polypeptide or regulatory regions.
[0015] In another embodiment, the isolated nucleic acid molecule is
at least 15 nucleotides in length and hybridizes under stringent
conditions to a nucleic acid molecule comprising a nucleotide
sequence of Appendix A. Preferably, the isolated nucleic acid
molecule corresponds to a naturally-occurring nucleic acid
molecule. More preferably, the isolated nucleic acid encodes a
naturally-occurring C. glutamicum MCP protein, or a biologically
active portion thereof.
[0016] Another aspect of the invention pertains to vectors, e.g.,
recombinant expression vectors, containing the nucleic acid
molecules of the invention, and host cells into which such vectors
have been introduced. In one embodiment, such a host cell is used
to produce an MCP protein by culturing the host cell in a suitable
medium. The MCP protein can then be isolated from the medium or the
host cell.
[0017] Yet another aspect of the invention pertains to a
genetically altered microorganism in which an MCP gene has been
introduced or altered. In one embodiment, the genome of the
microorganism has been altered by introduction of a nucleic acid
molecule of the invention encoding wild-type or mutated MCP
sequence as a transgene. In another embodiment, an endogenous MCP
gene within the genome of the microorganism has been altered, e.g.,
functionally disrupted, by homologous recombination with an altered
MCP gene. In another embodiment, an endogenous or introduced MCP
gene in a microorganism has been altered by one or more point
mutations, deletions, or inversions, but still encodes a functional
MCP protein. In still another embodiment, one or more of the
regulatory regions (e.g., a promoter, repressor, or inducer) of an
MCP gene in a microorganism has been altered (e.g., by deletion,
truncation, inversion, or point mutation) such that the expression
of the MCP gene is modulated. In a preferred embodiment, the
microorganism belongs to the genus Corynebacterium or
Brevibacterium, with Corynebacterium glutamicum being particularly
preferred. In a preferred embodiment, the microorganism is also
utilized for the production of a desired compound, such as an amino
acid, with lysine being particularly preferred.
[0018] In another aspect, the invention provides a method of
identifying the presence or activity of Cornyebacterium diphtheriae
in a subject. This method includes detection of one or more of the
nucleic acid or amino acid sequences of the invention (e.g., the
sequences set forth in Appendix A or Appendix B) in a subject,
thereby detecting the presence or activity of Corynebacterium
diphtheriae in the subject.
[0019] Still another aspect of the invention pertains to an
isolated MCP protein or a portion, e.g., a biologically active
portion, thereof. In a preferred embodiment, the isolated MCP
protein or portion thereof is capable of modulating the production
or efficiency of production of one or more fine chemicals from C.
glutamicum, or of serving as an identifying marker for C.
glutamicum or related organisms. In another preferred embodiment,
the isolated MCP protein or portion thereof is sufficiently
homologous to an amino acid sequence of Appendix B such that the
protein or portion thereof maintains the ability to, for example,
modulate the production or efficiency of production of one or more
fine chemicals from C. glutamicum, or to serve as identifying
markers for C. glutamicum or related organisms.
[0020] The invention also provides an isolated preparation of an
MCP protein. In preferred embodiments, the MCP protein comprises an
amino acid sequence of Appendix B. In another preferred embodiment,
the invention pertains to an isolated full length protein which is
substantially homologous to an entire amino acid sequence of
Appendix B (encoded by an open reading frame set forth in Appendix
A). In yet another embodiment, the protein is at least about 50%,
preferably at least about 60%, and more preferably at least about
70%, 80%, or 90%, and most preferably at least about 95%, 96%, 97%,
98%, or 99% or more homologous to an entire amino acid sequence of
Appendix B. In other embodiments, the isolated MCP protein
comprises an amino acid sequence which is at least about 50% or
more homologous to one of the amino acid sequences of Appendix B
and is able to modulate the yield, production, and/or efficiency of
production of one or more fine chemicals from C. glutamicum, to
degrade hydrocarbons, to oxidize terpenoids, to serve as a target
for drug development, or to serve as an identifying marker for C.
glutamicum or related organisms.
[0021] Alternatively, the isolated MCP protein can comprise an
amino acid sequence which is encoded by a nucleotide sequence which
hybridizes, e.g., hybridizes under stringent conditions, or is at
least about 50%, preferably at least about 60%, more preferably at
least about 70%, 80%, or 90%, and even more preferably at least
about 95%, 96%, 97%, 98,%, or 99% or more homologous, to a
nucleotide sequence of Appendix B. It is also preferred that the
preferred forms of MCP proteins also have one or more of the MCP
bioactivities described herein.
[0022] The MCP polypeptide, or a biologically active portion
thereof, can be operatively linked to a non-MCP polypeptide to form
a fusion protein. In preferred embodiments, this fusion protein has
an activity which differs from that of the MCP protein alone. In
other preferred embodiments, this fusion protein is capable of
modulating the yield, production and/or efficiency of production of
one or more fine chemicals from C. glutamicum, or of serving as an
identifying marker for C. glutamicum or related organisms. In
particularly preferred embodiments, integration of this fusion
protein into a host cell modulates production of a desired compound
from the cell.
[0023] In another aspect, the invention provides methods for
screening molecules which modulate the activity of an MCP protein,
either by interacting with the protein itself or a substrate or
binding partner of the MCP protein, or by modulating the
transcription or translation of an MCP nucleic acid molecule of the
invention.
[0024] Another aspect of the invention pertains to a method for
producing a fine chemical. This method involves the culturing of a
cell containing a vector directing the expression of an MCP nucleic
acid molecule of the invention, such that a fine chemical is
produced. In a preferred embodiment, this method further includes
the step of obtaining a cell containing such a vector, in which a
cell is transfected with a vector directing the expression of an
MCP nucleic acid. In another preferred embodiment, this method
further includes the step of recovering the fine chemical from the
culture. In a particularly preferred embodiment, the cell is from
the genus Corynebacterium or Brevibacterium, or is selected from
those strains set forth in Table 3.
[0025] Another aspect of the invention pertains to methods for
modulating production of a molecule from a microorganism. Such
methods include contacting the cell with an agent which modulates
MCP protein activity or MCP nucleic acid expression such that a
cell associated activity is altered relative to this same activity
in the absence of the agent. In a preferred embodiment, the cell is
modulated for one or more C. glutamicum MCP protein activities,
such that the yield, production, and/or efficiency of production of
a desired fine chemical by this microorganism is improved. The
agent which modulates MCP protein activity can be an agent which
stimulates MCP protein activity or MCP nucleic acid expression.
Examples of agents which stimulate MCP protein activity or MCP
nucleic acid expression include small molecules, active MCP
proteins, and nucleic acids encoding MCP proteins that have been
introduced into the cell. Examples of agents which inhibit MCP
activity or expression include small molecules and antisense MCP
nucleic acid molecules.
[0026] Another aspect of the invention pertains to methods for
modulating yields, production, and/or efficiency of production of a
desired compound from a cell, involving the introduction of a
wild-type or mutant MCP gene into a cell, either maintained on a
separate plasmid or integrated into the genome of the host cell. If
integrated into the genome, such integration can be random, or it
can take place by homologous recombination such that the native
gene is replaced by the introduced copy, causing the production of
the desired compound from the cell to be modulated. In a preferred
embodiment, said yields are increased. In another preferred
embodiment, said chemical is a fine chemical. In a particularly
preferred embodiment, said fine chemical is an amino acid. In
especially preferred embodiments, said amino acid is L-lysine.
DETAILED DESCRIPTION OF THE INVENTION
[0027] The present invention provides MCP nucleic acid and protein
molecules. These MCP nucleic acid molecules may be utilized in the
identification of Corynebacterium glutamicum or related organisms,
in the mapping of the C. glutamicum genome (or a genome of a
closely related organism), or in the identification of
microorganisms which may be used to produce fine chemicals, e.g.,
by fermentation processes. The proteins encoded by these nucleic
acids may be utilized in the direct or indirect modulation of the
production or efficiency of production of one or more fine
chemicals from C. glutamicum, as identifying markers for C.
glutamicum or related organisms, in the oxidation of terpenoids or
the degradation of hydrocarbons, or as targets for the development
of therapeutic pharmaceutical compounds. Aspects of the invention
are further explicated below.
I. Fine Chemicals
[0028] The term `fine chemical` is art-recognized and includes
molecules produced by an organism which have applications in
various industries, such as, but not limited to, the
pharmaceutical, agriculture, and cosmetics industries. Such
compounds include organic acids, such as tartaric acid, itaconic
acid, and diaminopimelic acid, both proteinogenic and
non-proteinogenic amino acids, purine and pyrimidine bases,
nucleosides, and nucleotides (as described e.g. in Kuninaka, A.
(1996) Nucleotides and related compounds, p. 561-612, in
Biotechnology vol. 6, Rehm et al., eds. VCH: Weinheim, and
references contained therein), lipids, both saturated and
unsaturated fatty acids (e.g., arachidonic acid), diols (e.g.,
propane diol, and butane diol), carbohydrates (e.g., hyaluronic
acid and trehalose), aromatic compounds (e.g., aromatic amines,
vanillin, and indigo), vitamins and cofactors (as described in
Ullmann's Encyclopedia of Industrial Chemistry, vol. A27,
"Vitamins", p. 443-613 (1996) VCH: Weinheim and references therein;
and Ong, A. S., Niki, E. & Packer, L. (1995) "Nutrition,
Lipids, Health, and Disease" Proceedings of the
UNESCO/Confederation of Scientific and Technological Associations
in Malaysia, and the Society for Free Radical Research--Asia, held
Sep. 1-3, 1994 at Penang, Malaysia, AOCS Press, (1995)), enzymes,
polyketides (Cane et al. (1998) Science 282: 63-68), and all other
chemicals described in Gutcho (1983) Chemicals by Fermentation,
Noyes Data Corporation, ISBN: 0818805086 and references therein.
The metabolism and uses of certain of these fine chemicals are
further explicated below.
A. Amino Acid Metabolism and Uses
[0029] Amino acids comprise the basic structural units of all
proteins, and as such are essential for normal cellular functioning
in all organisms. The term "amino acid" is art-recognized. The
proteinogenic amino acids, of which there are 20 species, serve as
structural units for proteins, in which they are linked by peptide
bonds, while the nonproteinogenic amino acids (hundreds of which
are known) are not normally found in proteins (see Ulmann's
Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97 VCH:
Weinheim (1985)). Amino acids may be in the D- or L-optical
configuration, though L-amino acids are generally the only type
found in naturally-occurring proteins. Biosynthetic and degradative
pathways of each of the 20 proteinogenic amino acids have been well
characterized in both prokaryotic and eukaryotic cells (see, for
example, Stryer, L. Biochemistry, 3.sup.rd edition, pages 578-590
(1988)). The `essential` amino acids (histidine, isoleucine,
leucine, lysine, methionine, phenylalanine, threonine, tryptophan,
and valine), so named because they are generally a nutritional
requirement due to the complexity of their biosyntheses, are
readily converted by simple biosynthetic pathways to the remaining
11 `nonessential` amino acids (alanine, arginine, asparagine,
aspartate, cysteine, glutamate, glutamine, glycine, proline,
serine, and tyrosine). Higher animals do retain the ability to
synthesize some of these amino acids, but the essential amino acids
must be supplied from the diet in order for normal protein
synthesis to occur.
[0030] Aside from their function in protein biosynthesis, these
amino acids are interesting chemicals in their own right, and many
have been found to have various applications in the food, feed,
chemical, cosmetics, agriculture, and pharmaceutical industries.
Lysine is an important amino acid in the nutrition not only of
humans, but also of monogastric animals such as poultry and swine.
Glutamate is most commonly used as a flavor additive (mono-sodium
glutamate, MSG) and is widely used throughout the food industry, as
are aspartate, phenylalanine, glycine, and cysteine. Glycine,
L-methionine and tryptophan are all utilized in the pharmaceutical
industry. Glutamine, valine, leucine, isoleucine, histidine,
arginine, proline, serine and alanine are of use in both the
pharmaceutical and cosmetics industries. Threonine, tryptophan, and
D/L-methionine are common feed additives. (Leuchtenberger, W.
(1996) Amino aids--technical production and use, p. 466-502 in Rehm
et al. (eds.) Biotechnology vol. 6, chapter 14a, VCH: Weinheim).
Additionally, these amino acids have been found to be useful as
precursors for the synthesis of synthetic amino acids and proteins,
such as N-acetylcysteine, S-carboxymethyl-L-cysteine,
(S)-5-hydroxytryptophan, and others described in Ulmann's
Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97, VCH:
Weinheim, 1985.
[0031] The biosynthesis of these natural amino acids in organisms
capable of producing them, such as bacteria, has been well
characterized (for review of bacterial amino acid biosynthesis and
regulation thereof, see Umbarger, H. E. (1978) Ann. Rev. Biochem.
47: 533-606). Glutamate is synthesized by the reductive amination
of .alpha.-ketoglutarate, an intermediate in the citric acid cycle.
Glutamine, proline, and arginine are each subsequently produced
from glutamate. The biosynthesis of serine is a three-step process
beginning with 3-phosphoglycerate (an intermediate in glycolysis),
and resulting in this amino acid after oxidation, transamination,
and hydrolysis steps. Both cysteine and glycine are produced from
serine; the former by the condensation of homocysteine with serine,
and the latter by the transferal of the side-chain .beta.-carbon
atom to tetrahydrofolate, in a reaction catalyzed by serine
transhydroxymethylase. Phenylalanine, and tyrosine are synthesized
from the glycolytic and pentose phosphate pathway precursors
erythrose 4-phosphate and phosphoenolpyruvate in a 9-step
biosynthetic pathway that differ only at the final two steps after
synthesis of prephenate. Tryptophan is also produced from these two
initial molecules, but its synthesis is an 11-step pathway.
Tyrosine may also be synthesized from phenylalanine, in a reaction
catalyzed by phenylalanine hydroxylase. Alanine, valine, and
leucine are all biosynthetic products of pyruvate, the final
product of glycolysis. Aspartate is formed from oxaloacetate, an
intermediate of the citric acid cycle. Asparagine, methionine,
threonine, and lysine are each produced by the conversion of
aspartate. Isoleucine is formed from threonine. A complex 9-step
pathway results in the production of histidine from
5-phosphoribosyl-1-pyrophosphate, an activated sugar.
[0032] Amino acids in excess of the protein synthesis needs of the
cell cannot be stored, and are instead degraded to provide
intermediates for the major metabolic pathways of the cell (for
review see Stryer, L. Biochemistry 3.sup.rd ed. Ch. 21 "Amino Acid
Degradation and the Urea Cycle" p. 495-516 (1988)). Although the
cell is able to convert unwanted amino acids into useful metabolic
intermediates, amino acid production is costly in terms of energy,
precursor molecules, and the enzymes necessary to synthesize them.
Thus it is not surprising that amino acid biosynthesis is regulated
by feedback inhibition, in which the presence of a particular amino
acid serves to slow or entirely stop its own production (for
overview of feedback mechanisms in amino acid biosynthetic
pathways, see Stryer, L. Biochemistry, 3.sup.rd ed. Ch. 24:
"Biosynthesis of Amino Acids and Heme" p. 575-600 (1988)). Thus,
the output of any particular amino acid is limited by the amount of
that amino acid present in the cell.
B. Vitamin, Cofactor, and Nutraceutical Metabolism and Uses
[0033] Vitamins, cofactors, and nutraceuticals comprise another
group of molecules which the higher animals have lost the ability
to synthesize and so must ingest, although they are readily
synthesized by other organisms such as bacteria. These molecules
are either bioactive substances themselves, or are precursors of
biologically active substances which may serve as electron carriers
or intermediates in a variety of metabolic pathways. Aside from
their nutritive value, these compounds also have significant
industrial value as coloring agents, antioxidants, and catalysts or
other processing aids. (For an overview of the structure, activity,
and industrial applications of these compounds, see, for example,
Ullman's Encyclopedia of Industrial Chemistry, "Vitamins" vol. A27,
p. 443-613, VCH: Weinheim, 1996.) The term "vitamin" is
art-recognized, and includes nutrients which are required by an
organism for normal functioning, but which that organism cannot
synthesize by itself. The group of vitamins may encompass cofactors
and nutraceutical compounds. The language "cofactor" includes
nonproteinaceous compounds required for a normal enzymatic activity
to occur. Such compounds may be organic or inorganic; the cofactor
molecules of the invention are preferably organic. The term
"nutraceutical" includes dietary supplements having health benefits
in plants and animals, particularly humans. Examples of such
molecules are vitamins, antioxidants, and also certain lipids
(e.g., polyunsaturated fatty acids).
[0034] The biosynthesis of these molecules in organisms capable of
producing them, such as bacteria, has been largely characterized
(Ullman's Encyclopedia of Industrial Chemistry, "Vitamins" vol.
A27, p. 443-613, VCH: Weinheim, 1996; Michal, G. (1999) Biochemical
Pathways: An Atlas of Biochemistry and Molecular Biology, John
Wiley & Sons; Ong, A. S., Niki, E. & Packer, L. (1995)
"Nutrition, Lipids, Health, and Disease" Proceedings of the
UNESCO/Confederation of Scientific and Technological Associations
in Malaysia, and the Society for Free Radical Research--Asia, held
Sep. 1-3, 1994 at Penang, Malaysia, AOCS Press: Champaign, Ill. X,
374 S).
[0035] Thiamin (vitamin B.sub.1) is produced by the chemical
coupling of pyrimidine and thiazole moieties. Riboflavin (vitamin
B.sub.2) is synthesized from guanosine-5'-triphosphate (GTP) and
ribose-5'-phosphate. Riboflavin, in turn, is utilized for the
synthesis of flavin mononucleotide (FMN) and flavin adenine
dinucleotide (FAD). The family of compounds collectively termed
`vitamin B.sub.6` (e.g., pyridoxine, pyridoxamine,
pyridoxa-5'-phosphate, and the commercially used pyridoxin
hydrochloride) are all derivatives of the common structural unit,
5-hydroxy-6-methylpyridine. Pantothenate (pantothenic acid,
(R)-(+)-N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-.beta.-alanine)
can be produced either by chemical synthesis or by fermentation.
The final steps in pantothenate biosynthesis consist of the
ATP-driven condensation of .beta.-alanine and pantoic acid. The
enzymes responsible for the biosynthesis steps for the conversion
to pantoic acid, to .beta.-alanine and for the condensation to
panthotenic acid are known. The metabolically active form of
pantothenate is Coenzyme A, for which the biosynthesis proceeds in
5 enzymatic steps. Pantothenate, pyridoxal-5'-phosphate, cysteine
and ATP are the precursors of Coenzyme A. These enzymes not only
catalyze the formation of panthothante, but also the production of
(R)-pantoic acid, (R)-pantolacton, (R)-panthenol (provitamin
B.sub.5), pantetheine (and its derivatives) and coenzyme A.
[0036] Biotin biosynthesis from the precursor molecule pimeloyl-CoA
in microorganisms has been studied in detail and several of the
genes involved have been identified. Many of the corresponding
proteins have been found to also be involved in Fe-cluster
synthesis and are members of the nifS class of proteins. Lipoic
acid is derived from octanoic acid, and serves as a coenzyme in
energy metabolism, where it becomes part of the pyruvate
dehydrogenase complex and the .alpha.-ketoglutarate dehydrogenase
complex. The folates are a group of substances which are all
derivatives of folic acid, which is turn is derived from L-glutamic
acid, p-amino-benzoic acid and 6-methylpterin. The biosynthesis of
folic acid and its derivatives, starting from the metabolism
intermediates guanosine-5'-triphosphate (GTP), L-glutamic acid and
p-amino-benzoic acid has been studied in detail in certain
microorganisms.
[0037] Corrinoids (such as the cobalamines and particularly vitamin
B.sub.12) and porphyrines belong to a group of chemicals
characterized by a tetrapyrole ring system. The biosynthesis of
vitamin B.sub.12 is sufficiently complex that it has not yet been
completely characterized, but many of the enzymes and substrates
involved are now known. Nicotinic acid (nicotinate), and
nicotinamide are pyridine derivatives which are also termed
`niacin`. Niacin is the precursor of the important coenzymes NAD
(nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine
dinucleotide phosphate) and their reduced forms.
[0038] The large-scale production of these compounds has largely
relied on cell-free chemical syntheses, though some of these
chemicals have also been produced by large-scale culture of
microorganisms, such as riboflavin, Vitamin B.sub.6, pantothenate,
and biotin. Only Vitamin B.sub.12 is produced solely by
fermentation, due to the complexity of its synthesis. In vitro
methodologies require significant inputs of materials and time,
often at great cost.
C. Purine, Pyrimidine, Nucleoside and Nucleotide Metabolism and
Uses
[0039] Purine and pyrimidine metabolism genes and their
corresponding proteins are important targets for the therapy of
tumor diseases and viral infections. The language "purine" or
"pyrimidine" includes the nitrogenous bases which are constituents
of nucleic acids, co-enzymes, and nucleotides. The term
"nucleotide" includes the basic structural units of nucleic acid
molecules, which are comprised of a nitrogenous base, a pentose
sugar (in the case of RNA, the sugar is ribose; in the case of DNA,
the sugar is D-deoxyribose), and phosphoric acid. The language
"nucleoside" includes molecules which serve as precursors to
nucleotides, but which are lacking the phosphoric acid moiety that
nucleotides possess. By inhibiting the biosynthesis of these
molecules, or their mobilization to form nucleic acid molecules, it
is possible to inhibit RNA and DNA synthesis; by inhibiting this
activity in a fashion targeted to cancerous cells, the ability of
tumor cells to divide and replicate may be inhibited. Additionally,
there are nucleotides which may serve as energy stores (e.g., ADP,
ATP) or as coenzymes (i.e., FAD and NAD).
[0040] Several publications have described the use of these
chemicals for these medical indications, by influencing purine
and/or pyrimidine metabolism (e.g. Christopherson, R. I. and Lyons,
S. D. (1990) "Potent inhibitors of de novo pyrimidine and purine
biosynthesis as chemotherapeutic agents." Med. Res. Reviews 10:
505-548). Studies of enzymes involved in purine and pyrimidine
metabolism have been focused on the development of new drugs which
can be used, for example, as immunosuppressants or
anti-proliferants (Smith, J. L., (1995) "Enzymes in nucleotide
synthesis." Curr. Opin. Struct. Biol. 5: 752-757; (1995) Biochem
Soc. Transact. 23: 877-902). However, purine and pyrimidine bases,
nucleosides and nucleotides have other utilities: as intermediates
in the biosynthesis of several fine chemicals (e.g., thiamine,
S-adenosyl-methionine, folates, or riboflavin), as energy carriers
for the cell (e.g., ATP or GTP), and for chemicals themselves,
commonly used as flavor enhancers (e.g., IMP or GMP) or for several
medicinal applications (see, for example, Kuninaka, A. (1996)
Nucleotides and Related Compounds in Biotechnology vol. 6, Rehm et
al., eds. VCH: Weinheim, p. 561-612). Also, enzymes involved in
purine, pyrimidine, nucleoside, or nucleotide metabolism are
increasingly serving as targets against which chemicals for crop
protection, including fungicides, herbicides and insecticides, are
developed.
[0041] The metabolism of these compounds in bacteria has been
characterized (for reviews see, for example, Zalkin, H. and Dixon,
J. E. (1992) "de novo purine nucleotide biosynthesis", in: Progress
in Nucleic Acid Research and Molecular Biology, vol. 42, Academic
Press:, p. 259-287; and Michal, G. (1999) "Nucleotides and
Nucleosides", Chapter 8 in: Biochemical Pathways: An Atlas of
Biochemistry and Molecular Biology, Wiley: New York). Purine
metabolism has been the subject of intensive research, and is
essential to the normal functioning of the cell. Impaired purine
metabolism in higher animals can cause severe disease, such as
gout. Purine nucleotides are synthesized from ribose-5-phosphate,
in a series of steps through the intermediate compound
inosine-5'-phosphate (IMP), resulting in the production of
guanosine-5'-monophosphate (GMP) or adenosine-5'-monophosphate
(AMP), from which the triphosphate forms utilized as nucleotides
are readily formed. These compounds are also utilized as energy
stores, so their degradation provides energy for many different
biochemical processes in the cell. Pyrimidine biosynthesis proceeds
by the formation of uridine-5'-monophosphate (UMP) from
ribose-5-phosphate. UMP, in turn, is converted to
cytidine-5'-triphosphate (CTP). The deoxy-forms of all of these
nucleotides are produced in a one step reduction reaction from the
diphosphate ribose form of the nucleotide to the diphosphate
deoxyribose form of the nucleotide. Upon phosphorylation, these
molecules are able to participate in DNA synthesis.
D. Trehalose Metabolism and Uses
[0042] Trehalose consists of two glucose molecules, bound in
.alpha., .alpha.-1,1 linkage. It is commonly used in the food
industry as a sweetener, an additive for dried or frozen foods, and
in beverages. However, it also has applications in the
pharmaceutical, cosmetics and biotechnology industries (see, for
example, Nishimoto et al., (1998) U.S. Pat. No. 5,759,610; Singer,
M. A. and Lindquist, S. (1998) Trends Biotech. 16: 460-467; Paiva,
C. L. A. and Panek, A. D. (1996) Biotech. Ann. Rev. 2: 293-314; and
Shiosaka, M. (1997) J. Japan 172: 97-102). Trehalose is produced by
enzymes from many microorganisms and is naturally released into the
surrounding medium, from which it can be collected using methods
known in the art.
II. Elements and Methods of the Invention
[0043] The present invention is based, at least in part, on the
discovery of novel molecules, referred to herein as MCP nucleic
acid molecules. These MCP nucleic acid molecules are useful not
only for the identification of C. glutamicum or related bacterial
species, but also as markers for the mapping of the C. glutamicum
genome and in the identification of bacteria useful for the
production of fine chemicals by, e.g., fermentative processes. The
present invention is also based, at least in part, on the MCP
protein molecules encoded by these MCP nucleic acid molecules.
These MCP proteins are capable of modulating the yield, production,
and/or efficiency of production of one or more fine chemicals from
C. glutamicum, of serving as identifying markers for C. glutamicum
or related organisms, of degrading hydrocarbons, and of serving as
targets for the development of therapeutic pharmaceutical
compounds. In one embodiment, the MCP molecules of the invention
directly or indirectly participate in one or more fine chemical
metabolic pathways in C. glutamicum. In a preferred embodiment, the
activity of the MCP molecules of the invention to indirectly or
directly participate in such metabolic pathways has an impact on
the production of a desired fine chemical by this microorganism. In
a particularly preferred embodiment, the MCP molecules of the
invention are modulated in activity, such that the C. glutamicum
metabolic pathways in which the MCP proteins of the invention
participate are modulated in efficiency or output, which either
directly or indirectly modulates the production or efficiency of
production of a desired fine chemical by C. glutamicum.
[0044] The language, "MCP protein" or "MCP polypeptide" includes
proteins which are able to modulate the yield, production, and/or
efficiency of production of one or more fine chemicals from C.
glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to
serve as a target protein for drug screening or design, or to serve
as identifying markers for C. glutamicum or related organisms.
Examples of MCP proteins include those encoded by the MCP genes set
forth in Table 1 and Appendix A. The terms "MCP gene" or "MCP
nucleic acid sequence" include nucleic acid sequences encoding an
MCP protein, which consist of a coding region and also
corresponding untranslated 5' and 3' sequence regions. Examples of
MCP genes include those set forth in Table 1. The terms
"production" or "productivity" are art-recognized and include the
concentration of the fermentation product (for example, the desired
fine chemical) formed within a given time and a given fermentation
volume (e.g., kg product per hour per liter). The term "efficiency
of production" includes the time required for a particular level of
production to be achieved (for example, how long it takes for the
cell to attain a particular rate of output of a fine chemical). The
term "yield" or "product/carbon yield" is art-recognized and
includes the efficiency of the conversion of the carbon source into
the product (i.e., fine chemical). This is generally written as,
for example, kg product per kg carbon source. By increasing the
yield or production of the compound, the quantity of recovered
molecules, or of useful recovered molecules of that compound in a
given amount of culture over a given amount of time is increased.
The terms "biosynthesis" or a "biosynthetic pathway" are
art-recognized and include the synthesis of a compound, preferably
an organic compound, by a cell from intermediate compounds in what
may be a multistep and highly regulated process. The terms
"degradation" or a "degradation pathway" are art-recognized and
include the breakdown of a compound, preferably an organic
compound, by a cell to degradation products (generally speaking,
smaller or less complex molecules) in what may be a multistep and
highly regulated process. The language "metabolism" is
art-recognized and includes the totality of the biochemical
reactions that take place in an organism. The metabolism of a
particular compound, then, (e.g., the metabolism of an amino acid
such as glycine) comprises the overall biosynthetic, modification,
and degradation pathways in the cell related to this compound.
[0045] In another embodiment, the MCP molecules of the invention
are capable of modulating the production of a desired molecule,
such as a fine chemical, in a microorganism such as C. glutamicum,
either directly or indirectly. Using recombinant genetic
techniques, one or more of the MCP proteins of the invention may be
manipulated such that its function is modulated. Such modulation of
function may result in the modulation of the yield, production,
and/or efficiency of production of one or more fine chemicals from
C. glutamicum.
[0046] For example, by modifying the activity of a protein involved
in the biosynthesis or degradation of a fine chemical (i.e.,
through mutagenesis of the corresponding gene), one may directly
modulate the ability of the cell to synthesize or to degrade this
compound, thereby modulating the yield and/or efficiency of
production of the fine chemical. Similarly, by modulating the
activity of a protein which regulates a fine chemical metabolic
pathway, one may directly influence whether the production of the
desired compound is up- or down-regulated, either of which will
modulate the yield or efficiency of production of the fine chemical
from the cell.
[0047] Indirect modulation of fine chemical production may also
result by modifying the activity of a protein of the invention
(i.e., by mutagenesis of the corresponding gene) such that the
overall ability of the cell to grow and divide or to remain viable
and productive is increased. The production of fine chemicals from
C. glutamicum is generally accomplished by the large-scale
fermentative culture of these microorganisms, conditions which are
frequently suboptimal for growth and cell division. By engineering
a protein of the invention (e.g., a stress response protein, a cell
wall protein, or proteins involved in the metabolism of compounds
necessary for cell growth and division to occur, such as
nucleotides and amino acids) such that it is better able to
survive, grow, and multiply in such conditions, it may be possible
to increase the number and productivity of such engineered C.
glutamicum cells in large-scale culture, which in turn should
result in increased yields and/or efficiency of production of one
or more desired fine chemicals. Further, the metabolic pathways of
any cell are necessarily interrelated and coregulated. By altering
the activity or regulation of any one metabolic pathway in C.
glutamicum (i.e., by altering the activity of one of the proteins
of the invention which participates in such a pathway), it is
possible to concomitantly alter the activity or regulation of other
metabolic pathways in this microorganism, which may be directly
involved in the synthesis or degradation of a fine chemical.
[0048] The isolated nucleic acid sequences of the invention are
contained within the genome of a Corynebacterium glutamicum strain
available through the American Type Culture Collection, given
designation ATCC 13032. The nucleotide sequences of the isolated C.
glutamicum MCP nucleic acid molecules and the predicted amino acid
sequences of the C. glutamicum MCP proteins are shown in Appendices
A and B, respectively. Computational analyses were performed which
classified and/or identified many of these nucleotide sequences as
sequences having homology to E. coli or Bacillus subtilis
genes.
[0049] The present invention also pertains to proteins which have
an amino acid sequence which is substantially homologous to an
amino acid sequence of Appendix B. As used herein, a protein which
has an amino acid sequence which is substantially homologous to a
selected amino acid sequence is least about 50% homologous to the
selected amino acid sequence, e.g., the entire selected amino acid
sequence. A protein which has an amino acid sequence which is
substantially homologous to a selected amino acid sequence can also
be least about 50-60%, preferably at least about 60-70%, and more
preferably at least about 70-80%, 80-90%, or 90-95%, and most
preferably at least about 96%, 97%, 98%, 99% or more homologous to
the selected amino acid sequence.
[0050] The MCP protein or a biologically active portion or fragment
thereof of the invention is able to modulate the yield, production,
and/or efficiency of production of one or more fine chemicals from
C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to
serve as a target for drug development, or to serve as an
identifying marker for C. glutamicum or related organisms.
[0051] Various aspects of the invention are described in further
detail in the following subsections:
A. Isolated Nucleic Acid Molecules
[0052] One aspect of the invention pertains to isolated nucleic
acid molecules that encode MCP polypeptides or biologically active
portions thereof, as well as nucleic acid fragments sufficient for
use as hybridization probes or primers for the identification or
amplification of MCP-encoding nucleic acid (e.g., MCP DNA). These
nucleic acid molecules may be used to identify C. glutamicum or
related organisms, to map the genome of C. glutamicum or closely
related bacteria, or to identify microorganisms useful for the
production of fine chemicals, e.g., by fermentative processes. As
used herein, the term "nucleic acid molecule" is intended to
include DNA molecules (e.g., cDNA or genomic DNA) and RNA molecules
(e.g., mRNA) and analogs of the DNA or RNA generated using
nucleotide analogs. This term also encompasses untranslated
sequence located at both the 3' and 5' ends of the coding region of
the gene: at least about 100 nucleotides of sequence upstream from
the 5' end of the coding region and at least about 20 nucleotides
of sequence downstream from the 3'end of the coding region of the
gene. The nucleic acid molecule can be single-stranded or
double-stranded, but preferably is double-stranded DNA. An
"isolated" nucleic acid molecule is one which is separated from
other nucleic acid molecules which are present in the natural
source of the nucleic acid. Preferably, an "isolated" nucleic acid
is free of sequences which naturally flank the nucleic acid (i.e.,
sequences located at the 5' and 3' ends of the nucleic acid) in the
genomic DNA of the organism from which the nucleic acid is derived.
For example, in various embodiments, the isolated MCP nucleic acid
molecule can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 kb,
0.5 kb or 0.1 kb of nucleotide sequences which naturally flank the
nucleic acid molecule in genomic DNA of the cell from which the
nucleic acid is derived (e.g., a C. glutamicum cell). Moreover, an
"isolated" nucleic acid molecule, such as a DNA molecule, can be
substantially free of other cellular material, or culture medium
when produced by recombinant techniques, or chemical precursors or
other chemicals when chemically synthesized.
[0053] A nucleic acid molecule of the present invention, e.g., a
nucleic acid molecule having a nucleotide sequence of Appendix A,
or a portion thereof, can be isolated using standard molecular
biology techniques and the sequence information provided herein.
For example, a C. glutamicum MCP DNA can be isolated from a C.
glutamicum library using all or portion of one of the sequences of
Appendix A as a hybridization probe and standard hybridization
techniques (e.g., as described in Sambrook, J., Fritsh, E. F., and
Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold
Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold
Spring Harbor, N.Y., 1989). Moreover, a nucleic acid molecule
encompassing all or a portion of one of the sequences of Appendix A
can be isolated by the polymerase chain reaction using
oligonucleotide primers designed based upon this sequence (e.g., a
nucleic acid molecule encompassing all or a portion of one of the
sequences of Appendix A can be isolated by the polymerase chain
reaction using oligonucleotide primers designed based upon this
same sequence of Appendix A). For example, mRNA can be isolated
from normal endothelial cells (e.g., by the guanidinium-thiocyanate
extraction procedure of Chirgwin et al. (1979) Biochemistry 18:
5294-5299) and DNA can be prepared using reverse transcriptase
(e.g., Moloney MLV reverse transcriptase, available from Gibco/BRL,
Bethesda, Md.; or AMV reverse transcriptase, available from
Seikagaku America, Inc., St. Petersburg, Fla.) and random
polynucleotide primers or oligonucleotide primers based upon one of
the nucleotide sequences shown in Appendix A. Synthetic
oligonucleotide primers for polymerase chain reaction amplification
can be designed based upon one of the nucleotide sequences shown in
Appendix A. A nucleic acid of the invention can be amplified using
cDNA or, alternatively, genomic DNA, as a template and appropriate
oligonucleotide primers according to standard PCR amplification
techniques. The nucleic acid so amplified can be cloned into an
appropriate vector and characterized by DNA sequence analysis.
Furthermore, oligonucleotides corresponding to an MCP nucleotide
sequence can be prepared by standard synthetic techniques, e.g.,
using an automated DNA synthesizer.
[0054] In a preferred embodiment, an isolated nucleic acid molecule
of the invention comprises one of the nucleotide sequences shown in
Appendix A. The sequences of Appendix A correspond to the
Corynebacterium glutamicum MCP DNAs of the invention. This cDNA
comprises sequences encoding MCP proteins (i.e., the "coding
region", indicated in each sequence in Appendix A), as well as 5'
untranslated sequences and 3' untranslated sequences, also
indicated in Appendix A. Alternatively, the nucleic acid molecule
can comprise only the coding region of any of the sequences in
Appendix A.
[0055] For the purposes of this application, it will be understood
that each of the sequences set forth in Appendix A has an
identifying RXA or RXN number having the designation "RXA" or "RXN"
followed by 5 digits (i.e., RXA00003 or RXN0022). Each of these
sequences comprises up to three parts: a 5' upstream region, a
coding region, and a downstream region. Each of these three regions
is identified by the same RXA or RXN designation to eliminate
confusion. The recitation "one of the sequences in Appendix A",
then, refers to any of the sequences in Appendix A, which may be
distinguished by their differing RXA or RXN designations. The
coding region of each of these sequences is translated into a
corresponding amino acid sequence, which is set forth in Appendix
B. The sequences of Appendix B are identified by the same RXA or
RXN designations as Appendix A, such that they can be readily
correlated. For example, the amino acid sequence in Appendix B
designated RXA00003 is a translation of the coding region of the
nucleotide sequence of nucleic acid molecule RXA00003 in Appendix
A, and the amino acid sequence in Appendix B designated RXN00022 is
a translation of the coding region of the nucleotide sequence of
nucleic acid molecule RXN00022 in Appendix A. Each of the RXA and
RXN nucleotide and amino acid sequences of the invention has also
been assigned a SEQ ID NO, as indicated in Table 1.
[0056] Several of the genes of the invention are "F-designated
genes". An F-designated gene includes those genes set forth in
Table 1 which have an `F` in front of the RXA designation. For
example, SEQ ID NO:3, designated, as indicated on Table 1, as "F
RXA01638", is an F-designated gene, as are SEQ ID NOs: 5, 9, and 11
(designated on Table 1 as "F RXA01639", "F RXA01590", and "F
RXA01542", respectively).
[0057] In one embodiment, the nucleic acid molecules of the present
invention are not intended to include those compiled in Table
2.
[0058] In another preferred embodiment, an isolated nucleic acid
molecule of the invention comprises a nucleic acid molecule which
is a complement of one of the nucleotide sequences shown in
Appendix A, or a portion thereof. A nucleic acid molecule which is
complementary to one of the nucleotide sequences shown in Appendix
A is one which is sufficiently complementary to one of the
nucleotide sequences shown in Appendix A such that it can hybridize
to one of the nucleotide sequences shown in Appendix A, thereby
forming a stable duplex.
[0059] In still another preferred embodiment, an isolated nucleic
acid molecule of the invention comprises a nucleotide sequence
which is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%,
58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%,
65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about
71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%,
84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and
even more preferably at least about 95%, 96%, 97%, 98%, 99% or more
homologous to a nucleotide sequence shown in Appendix A, or a
portion thereof. Ranges and identity values intermediate to the
above-recited ranges, (e.g., 70-90% identical or 80-95% identical)
are also intended to be encompassed by the present invention. For
example, ranges of identity values using a combination of any of
the above values recited as upper and/or lower limits are intended
to be included. In an additional preferred embodiment, an isolated
nucleic acid molecule of the invention comprises a nucleotide
sequence which hybridizes, e.g., hybridizes under stringent
conditions, to one of the nucleotide sequences shown in Appendix A,
or a portion thereof.
[0060] Moreover, the nucleic acid molecule of the invention can
comprise only a portion of the coding region of one of the
sequences in Appendix A, for example a fragment which can be used
as a probe or primer or a fragment encoding a biologically active
portion of an MCP protein. The nucleotide sequences determined from
the cloning of the MCP genes from C. glutamicum allows for the
generation of probes and primers designed for use in identifying
and/or cloning MCP homologues in other cell types and organisms, as
well as MCP homologues from other Corynebacteria or related
species. The probe/primer typically comprises substantially
purified oligonucleotide. The oligonucleotide typically comprises a
region of nucleotide sequence that hybridizes under stringent
conditions to at least about 12, preferably about 25, more
preferably about 40, 50 or 75 consecutive nucleotides of a sense
strand of one of the sequences set forth in Appendix A, an
anti-sense sequence of one of the sequences set forth in Appendix
A, or naturally occurring mutants thereof. Primers based on a
nucleotide sequence of Appendix A can be used in PCR reactions to
clone MCP homologues. Probes based on the MCP nucleotide sequences
can be used to detect transcripts or genomic sequences encoding the
same or homologous proteins. In preferred embodiments, the probe
further comprises a label group attached thereto, e.g. the label
group can be a radioisotope, a fluorescent compound, an enzyme, or
an enzyme co-factor. Such probes can be used as a part of a
diagnostic test kit for identifying cells which misexpress an MCP
protein, such as by measuring a level of an MCP-encoding nucleic
acid in a sample of cells, e.g., detecting MCP mRNA levels or
determining whether a genomic MCP gene has been mutated or
deleted.
[0061] In one embodiment, the nucleic acid molecule of the
invention encodes a protein or portion thereof which includes an
amino acid sequence which is sufficiently homologous to an amino
acid sequence of Appendix B such that the protein or portion
thereof maintains the ability to modulate the yield, production,
and/or efficiency of production of one or more fine chemicals from
C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to
serve as a target for drug development, or to serve as an
identifying marker for C. glutamicum or related organisms. As used
herein, the language "sufficiently homologous" refers to proteins
or portions thereof which have amino acid sequences which include a
minimum number of identical or equivalent (e.g., an amino acid
residue which has a similar side chain as an amino acid residue in
one of the sequences of Appendix B) amino acid residues to an amino
acid sequence of Appendix B such that the protein or portion
thereof is able to modulate the yield, production, and/or
efficiency of production of one or more fine chemicals from C.
glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to
serve as a target for drug development, or to serve as an
identifying marker for C. glutamicum or related organisms. Examples
of such activities are also described herein. Thus, "the function
of an MCP protein" contributes to the overall regulation of one or
more fine chemical metabolic pathways, or to the degradation of a
hydrocarbon, or to the oxidation of a terpenoid.
[0062] In another embodiment, the protein is at least about 50-60%,
preferably at least about 60-70%, and more preferably at least
about 70-80%, 80-90%, 90-95%, and most preferably at least about
96%, 97%, 98%, 99% or more homologous to an entire amino acid
sequence of Appendix B.
[0063] Portions of proteins encoded by the MCP nucleic acid
molecules of the invention are preferably biologically active
portions of one of the MCP proteins. As used herein, the term
"biologically active portion of an MCP protein" is intended to
include a portion, e.g., a domain/motif, of an MCP protein that
modulates the yield, production, and/or efficiency of production of
one or more fine chemicals from C. glutamicum, that degrades
hydrocarbons, that oxidizes terpenoids, that may serve as a target
for drug development, or that may serve as an identifying marker
for C. glutamicum or related organisms. To determine whether an MCP
protein or a biologically active portion thereof can modulate the
yield, production, and/or efficiency of production of one or more
fine chemicals from C. glutamicum, can degrade hydrocarbons, or can
oxidize terpenoids, an assay of activity may be performed. Such
assay methods are well known to those of ordinary skill in the art,
as detailed in Example 8 of the Exemplification.
[0064] Additional nucleic acid fragments encoding biologically
active portions of an MCP protein can be prepared by isolating a
portion of one of the sequences in Appendix B, expressing the
encoded portion of the MCP protein or peptide (e.g., by recombinant
expression in vitro) and assessing the activity of the encoded
portion of the MCP protein or peptide.
[0065] The invention further encompasses nucleic acid molecules
that differ from one of the nucleotide sequences shown in Appendix
A (and portions thereof) due to degeneracy of the genetic code and
thus encode the same MCP protein as that encoded by the nucleotide
sequences shown in Appendix A. In another embodiment, an isolated
nucleic acid molecule of the invention has a nucleotide sequence
encoding a protein having an amino acid sequence shown in Appendix
B. In a still further embodiment, the nucleic acid molecule of the
invention encodes a full length C. glutamicum protein which is
substantially homologous to an amino acid sequence of Appendix B
(encoded by an open reading frame shown in Appendix A).
[0066] It will be understood by one of ordinary skill in the art
that in one embodiment the sequences of the invention are not meant
to include the sequences of the prior art, such as those Genbank
sequences set forth in Tables 2 or 4 which were available prior to
the present invention. In one embodiment, the invention includes
nucleotide and amino acid sequences having a percent identity to a
nucleotide or amino acid sequence of the invention which is greater
than that of a sequence of the prior art (e.g., a Genbank sequence
(or the protein encoded by such a sequence) set forth in Tables 2
or 4). For example, the invention includes a nucleotide sequence
which is greater than and/or at least 39% identical to the
nucleotide sequence designated RXA00008 (SEQ ID NO: 1549), a
nucleotide sequence which is greater than and/or at least 42%
identical to the nucleotide sequence designated RXA00059 (SEQ ID
NO:1571), and a nucleotide sequence which is greater than and/or at
least 39% identical to the nucleotide sequence designated RXA00096
(SEQ ID NO:93). One of ordinary skill in the art would be able to
calculate the lower threshold of percent identity for any given
sequence of the invention by examining the GAP-calculated percent
identity scores set forth in Table 4 for each of the three top hits
for the given sequence, and by subtracting the highest
GAP-calculated percent identity from 100 percent. One of ordinary
skill in the art will also appreciate that nucleic acid and amino
acid sequences having percent identities greater than the lower
threshold so calculated (e.g., at least 50%, 51%, 52%, 53%, 54%,
55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%,
62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at
least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%,
81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%,
93%, 94%, and even more preferably at least about 95%, 96%, 97%,
98%, 99% or more identical) are also encompassed by the
invention.
[0067] In addition to the C. glutamicum MCP nucleotide sequences
shown in Appendix A, it will be appreciated by those of ordinary
skill in the art that DNA sequence polymorphisms that lead to
changes in the amino acid sequences of MCP proteins may exist
within a population (e.g., the C. glutamicum population). Such
genetic polymorphism in the MCP gene may exist among individuals
within a population due to natural variation. As used herein, the
terms "gene" and "recombinant gene" refer to nucleic acid molecules
comprising an open reading frame encoding an MCP protein,
preferably a C. glutamicum MCP protein. Such natural variations can
typically result in 1-5% variance in the nucleotide sequence of the
MCP gene. Any and all such nucleotide variations and resulting
amino acid polymorphisms in MCP that are the result of natural
variation and that do not alter the functional activity of MCP
proteins are intended to be within the scope of the invention.
[0068] Nucleic acid molecules corresponding to natural variants and
non-C. glutamicum homologues of the C. glutamicum MCP DNA of the
invention can be isolated based on their homology to the C.
glutamicum MCP nucleic acid disclosed herein using the C.
glutamicum DNA, or a portion thereof, as a hybridization probe
according to standard hybridization techniques under stringent
hybridization conditions. Accordingly, in another embodiment, an
isolated nucleic acid molecule of the invention is at least 15
nucleotides in length and hybridizes under stringent conditions to
the nucleic acid molecule comprising a nucleotide sequence of
Appendix A. In other embodiments, the nucleic acid is at least 30,
50, 100, 250 or more nucleotides in length. As used herein, the
term "hybridizes under stringent conditions" is intended to
describe conditions for hybridization and washing under which
nucleotide sequences at least 60% homologous to each other
typically remain hybridized to each other. Preferably, the
conditions are such that sequences at least about 65%, more
preferably at least about 70%, and even more preferably at least
about 75% or more homologous to each other typically remain
hybridized to each other. Such stringent conditions are known to
those of ordinary skill in the art and can be found in Current
Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989),
6.3.1-6.3.6. A preferred, non-limiting example of stringent
hybridization conditions are hybridization in 6.times. sodium
chloride/sodium citrate (SSC) at about 45.degree. C., followed by
one or more washes in 0.2.times.SSC, 0.1% SDS at 50-65.degree. C.
Preferably, an isolated nucleic acid molecule of the invention that
hybridizes under stringent conditions to a sequence of Appendix A
corresponds to a naturally-occurring nucleic acid molecule. As used
herein, a "naturally-occurring" nucleic acid molecule refers to an
RNA or DNA molecule having a nucleotide sequence that occurs in
nature (e.g., encodes a natural protein). In one embodiment, the
nucleic acid encodes a natural C. glutamicum MCP protein.
[0069] In addition to naturally-occurring variants of the MCP
sequence that may exist in the population, one of ordinary skill in
the art will further appreciate that changes can be introduced by
mutation into a nucleotide sequence of Appendix A, thereby leading
to changes in the amino acid sequence of the encoded MCP protein,
without altering the functional ability of the MCP protein. For
example, nucleotide substitutions leading to amino acid
substitutions at "non-essential" amino acid residues can be made in
a sequence of Appendix A. A "non-essential" amino acid residue is a
residue that can be altered from the wild-type sequence of one of
the MCP proteins (Appendix B) without altering the activity of said
MCP protein, whereas an "essential" amino acid residue is required
for MCP protein activity. Other amino acid residues, however,
(e.g., those that are not conserved or only semi-conserved in the
domain having MCP activity) may not be essential for activity and
thus are likely to be amenable to alteration without altering MCP
activity.
[0070] Accordingly, another aspect of the invention pertains to
nucleic acid molecules encoding MCP proteins that contain changes
in amino acid residues that are not essential for MCP activity.
Such MCP proteins differ in amino acid sequence from a sequence
contained in Appendix B yet retain at least one of the MCP
activities described herein. In one embodiment, the isolated
nucleic acid molecule comprises a nucleotide sequence encoding a
protein, wherein the protein comprises an amino acid sequence at
least about 50% homologous to an amino acid sequence of Appendix B
and is able to modulate the yield, production, and/or efficiency of
production of one or more fine chemicals from C. glutamicum, to
degrade hydrocarbons, to oxidize terpenoids, to serve as a target
for drug development, or to serve as an identifying marker for C.
glutamicum or related organisms. Preferably, the protein encoded by
the nucleic acid molecule is at least about 50-60% homologous to
one of the sequences in Appendix B, more preferably at least about
60-70% homologous to one of the sequences in Appendix B, even more
preferably at least about 70-80%, 80-90%, 90-95% homologous to one
of the sequences in Appendix B, and most preferably at least about
96%, 97%, 98%, or 99% homologous to one of the sequences in
Appendix B.
[0071] To determine the percent homology of two amino acid
sequences (e.g., one of the sequences of Appendix B and a mutant
form thereof) or of two nucleic acids, the sequences are aligned
for optimal comparison purposes (e.g., gaps can be introduced in
the sequence of one protein or nucleic acid for optimal alignment
with the other protein or nucleic acid). The amino acid residues or
nucleotides at corresponding amino acid positions or nucleotide
positions are then compared. When a position in one sequence (e.g.,
one of the sequences of Appendix B) is occupied by the same amino
acid residue or nucleotide as the corresponding position in the
other sequence (e.g., a mutant form of the sequence selected from
Appendix B), then the molecules are homologous at that position
(i.e., as used herein amino acid or nucleic acid "homology" is
equivalent to amino acid or nucleic acid "identity"). The percent
homology between the two sequences is a function of the number of
identical positions shared by the sequences (i.e., % homology=# of
identical positions/total # of positions.times.100).
[0072] An isolated nucleic acid molecule encoding an MCP protein
homologous to a protein sequence of Appendix B can be created by
introducing one or more nucleotide substitutions, additions or
deletions into a nucleotide sequence of Appendix A such that one or
more amino acid substitutions, additions or deletions are
introduced into the encoded protein. Mutations can be introduced
into one of the sequences of Appendix A by standard techniques,
such as site-directed mutagenesis and PCR-mediated mutagenesis.
Preferably, conservative amino acid substitutions are made at one
or more predicted non-essential amino acid residues. A
"conservative amino acid substitution" is one in which the amino
acid residue is replaced with an amino acid residue having a
similar side chain. Families of amino acid residues having similar
side chains have been defined in the art. These families include
amino acids with basic side chains (e.g., lysine, arginine,
histidine), acidic side chains (e.g., aspartic acid, glutamic
acid), uncharged polar side chains (e.g., glycine, asparagine,
glutamine, serine, threonine, tyrosine, cysteine), nonpolar side
chains (e.g., alanine, valine, leucine, isoleucine, proline,
phenylalanine, methionine, tryptophan), beta-branched side chains
(e.g., threonine, valine, isoleucine) and aromatic side chains
(e.g., tyrosine, phenylalanine, tryptophan, histidine). Thus, a
predicted nonessential amino acid residue in an MCP protein is
preferably replaced with another amino acid residue from the same
side chain family. Alternatively, in another embodiment, mutations
can be introduced randomly along all or part of an MCP coding
sequence, such as by saturation mutagenesis, and the resultant
mutants can be screened for an MCP activity described herein to
identify mutants that retain MCP activity. Following mutagenesis of
one of the sequences of Appendix A, the encoded protein can be
expressed recombinantly and the activity of the protein can be
determined using, for example, assays described herein (see Example
8 of the Exemplification).
[0073] In addition to the nucleic acid molecules encoding MCP
proteins described above, another aspect of the invention pertains
to isolated nucleic acid molecules which are antisense thereto. An
"antisense" nucleic acid comprises a nucleotide sequence which is
complementary to a "sense" nucleic acid encoding a protein, e.g.,
complementary to the coding strand of a double-stranded cDNA
molecule or complementary to an mRNA sequence. Accordingly, an
antisense nucleic acid can hydrogen bond to a sense nucleic acid.
The antisense nucleic acid can be complementary to an entire MCP
coding strand, or to only a portion thereof. In one embodiment, an
antisense nucleic acid molecule is antisense to a "coding region"
of the coding strand of a nucleotide sequence encoding an MCP
protein. The term "coding region" refers to the region of the
nucleotide sequence comprising codons which are translated into
amino acid residues (e.g., the entire coding region of SEQ ID NO. 1
(RXN01638) comprises nucleotides 1 to 900). In another embodiment,
the antisense nucleic acid molecule is antisense to a "noncoding
region" of the coding strand of a nucleotide sequence encoding MCP.
The term "noncoding region" refers to 5' and 3' sequences which
flank the coding region that are not translated into amino acids
(i.e., also referred to as 5' and 3' untranslated regions).
[0074] Given the coding strand sequences encoding MCP disclosed
herein (e.g., the sequences set forth in Appendix A), antisense
nucleic acids of the invention can be designed according to the
rules of Watson and Crick base pairing. The antisense nucleic acid
molecule can be complementary to the entire coding region of MCP
mRNA, but more preferably is an oligonucleotide which is antisense
to only a portion of the coding or noncoding region of MCP mRNA.
For example, the antisense oligonucleotide can be complementary to
the region surrounding the translation start site of MCP mRNA. An
antisense oligonucleotide can be, for example, about 5, 10, 15, 20,
25, 30, 35, 40, 45 or 50 nucleotides in length. An antisense
nucleic acid of the invention can be constructed by chemical
synthesis and enzymatic ligation reactions using procedures known
in the art. For example, an antisense nucleic acid (e.g., an
antisense oligonucleotide) can be chemically synthesized using
naturally occurring nucleotides or variously modified nucleotides
designed to increase the biological stability of the molecules or
to increase the physical stability of the duplex formed between the
antisense and sense nucleic acids, e.g., phosphorothioate
derivatives and acridine substituted nucleotides can be used.
Examples of modified nucleotides which can be used to generate the
antisense nucleic acid include 5-fluorouracil, 5-bromouracil,
5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine,
4-acetylcytosine, 5-(carboxyhydroxylmethyl)uracil,
5-carboxymethylaminomethyl-2-thiouridine,
5-carboxymethylaminomethyluracil, dihydrouracil,
beta-D-galactosylqueosine, inosine, N6-isopentenyladenine,
1-methylguanine, 1-methylinosine, 2,2-dimethylguanine,
2-methyladenine, 2-methylguanine, 3-methylcytosine,
5-methylcytosine, N6-adenine, 7-methylguanine,
5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil,
beta-D-mannosylqueosine, 5'-methoxycarboxymethyluracil,
5-methoxyuracil, 2-methylthio-N6-isopentenyladenine,
uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine,
2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil,
5-methyluracil, uracil-5-oxyacetic acid methylester,
uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil,
3-(3-amino-3-N-2-carboxypropyl)uracil, (acp3)w, and
2,6-diaminopurine. Alternatively, the antisense nucleic acid can be
produced biologically using an expression vector into which a
nucleic acid has been subcloned in an antisense orientation (i.e.,
RNA transcribed from the inserted nucleic acid will be of an
antisense orientation to a target nucleic acid of interest,
described further in the following subsection).
[0075] The antisense nucleic acid molecules of the invention are
typically administered to a cell or generated in situ such that
they hybridize with or bind to cellular mRNA and/or genomic DNA
encoding an MCP protein to thereby inhibit expression of the
protein, e.g., by inhibiting transcription and/or translation. The
hybridization can be by conventional nucleotide complementarity to
form a stable duplex, or, for example, in the case of an antisense
nucleic acid molecule which binds to DNA duplexes, through specific
interactions in the major groove of the double helix. The antisense
molecule can be modified such that it specifically binds to a
receptor or an antigen expressed on a selected cell surface, e.g.,
by linking the antisense nucleic acid molecule to a peptide or an
antibody which binds to a cell surface receptor or antigen. The
antisense nucleic acid molecule can also be delivered to cells
using the vectors described herein. To achieve sufficient
intracellular concentrations of the antisense molecules, vector
constructs in which the antisense nucleic acid molecule is placed
under the control of a strong prokaryotic, viral, or eukaryotic
promoter are preferred.
[0076] In yet another embodiment, the antisense nucleic acid
molecule of the invention is an .alpha.-anomeric nucleic acid
molecule. An .alpha.-anomeric nucleic acid molecule forms specific
double-stranded hybrids with complementary RNA in which, contrary
to the usual .beta.-units, the strands run parallel to each other
(Gaultier et al. (1987) Nucleic Acids. Res. 15:6625-6641). The
antisense nucleic acid molecule can also comprise a
2'-o-methylribonucleotide (Inoue et al. (1987) Nucleic Acids Res.
15:6131-6148) or a chimeric RNA-DNA analogue (Inoue et al. (1987)
FEBS Lett. 215:327-330).
[0077] In still another embodiment, an antisense nucleic acid of
the invention is a ribozyme. Ribozymes are catalytic RNA molecules
with ribonuclease activity which are capable of cleaving a
single-stranded nucleic acid, such as an mRNA, to which they have a
complementary region. Thus, ribozymes (e.g., hammerhead ribozymes
(described in Haselhoff and Gerlach (1988) Nature 334:585-591)) can
be used to catalytically cleave MCP mRNA transcripts to thereby
inhibit translation of MCP mRNA. A ribozyme having specificity for
an MCP-encoding nucleic acid can be designed based upon the
nucleotide sequence of an MCP DNA disclosed herein (i.e., SEQ ID
NO. 1 (RXN01368) in Appendix A). For example, a derivative of a
Tetrahymena L-19 IVS RNA can be constructed in which the nucleotide
sequence of the active site is complementary to the nucleotide
sequence to be cleaved in an MCP-encoding mRNA. See, e.g., Cech et
al. U.S. Pat. No. 4,987,071 and Cech et al. U.S. Pat. No.
5,116,742. Alternatively, MCP mRNA can be used to select a
catalytic RNA having a specific ribonuclease activity from a pool
of RNA molecules. See, e.g., Bartel, D. and Szostak, J. W. (1993)
Science 261:1411-1418.
[0078] Alternatively, MCP gene expression can be inhibited by
targeting nucleotide sequences complementary to the regulatory
region of an MCP nucleotide sequence (e.g., an MCP promoter and/or
enhancers) to form triple helical structures that prevent
transcription of an MCP gene in target cells. See generally,
Helene, C. (1991) Anticancer Drug Des. 6(6):569-84; Helene, C. et
al. (1992) Ann. N.Y. Acad. Sci. 660:27-36; and Maher, L. J. (1992)
Bioassays 14(12):807-15.
B. Recombinant Expression Vectors and Host Cells
[0079] Another aspect of the invention pertains to vectors,
preferably expression vectors, containing a nucleic acid encoding
an MCP protein (or a portion thereof). As used herein, the term
"vector" refers to a nucleic acid molecule capable of transporting
another nucleic acid to which it has been linked. One type of
vector is a "plasmid", which refers to a circular double stranded
DNA loop into which additional DNA segments can be ligated. Another
type of vector is a viral vector, wherein additional DNA segments
can be ligated into the viral genome. Certain vectors are capable
of autonomous replication in a host cell into which they are
introduced (e.g., bacterial vectors having a bacterial origin of
replication and episomal mammalian vectors). Other vectors (e.g.,
non-episomal mammalian vectors) are integrated into the genome of a
host cell upon introduction into the host cell, and thereby are
replicated along with the host genome. Moreover, certain vectors
are capable of directing the expression of genes to which they are
operatively linked. Such vectors are referred to herein as
"expression vectors". In general, expression vectors of utility in
recombinant DNA techniques are often in the form of plasmids. In
the present specification, "plasmid" and "vector" can be used
interchangeably as the plasmid is the most commonly used form of
vector. However, the invention is intended to include such other
forms of expression vectors, such as viral vectors (e.g.,
replication defective retroviruses, adenoviruses and
adeno-associated viruses), which serve equivalent functions.
[0080] The recombinant expression vectors of the invention comprise
a nucleic acid of the invention in a form suitable for expression
of the nucleic acid in a host cell, which means that the
recombinant expression vectors include one or more regulatory
sequences, selected on the basis of the host cells to be used for
expression, which is operatively linked to the nucleic acid
sequence to be expressed. Within a recombinant expression vector,
"operably linked" is intended to mean that the nucleotide sequence
of interest is linked to the regulatory sequence(s) in a manner
which allows for expression of the nucleotide sequence (e.g., in an
in vitro transcription/translation system or in a host cell when
the vector is introduced into the host cell). The term "regulatory
sequence" is intended to include promoters, repressor binding
sites, activator binding sites, enhancer regions and other
expression control elements (e.g., terminators, other elements of
mRNA secondary structure, or polyadenylation signals). Such
regulatory sequences are described, for example, in Goeddel; Gene
Expression Technology: Methods in Enzymology 185, Academic Press,
San Diego, Calif. (1990). Regulatory sequences include those which
direct constitutive expression of a nucleotide sequence in many
types of host cell and those which direct expression of the
nucleotide sequence only in certain host cells. Preferred
regulatory sequences are, for example, promoters such as cos-,
tac-, trp-, tet-, trp-tet-, lpp-, lac-, lpp-lac-, lacI.sup.q-, T7-,
T5-, T3-, gal-, trc-, ara-, SP6-, arny, SPO2, .lamda.-P.sub.R- or
.lamda.P.sub.L, which are used preferably in bacteria. Additional
regulatory sequences are, for example, promoters from yeasts and
fungi, such as ADC1, MF.alpha., AC, P-60, CYC1, GAPDH, TEF, rp28,
ADH, promoters from plants such as CaMV/35S, SSU, OCS, lib4, usp,
STLS1, B33, nos or ubiquitin- or phaseolin-promoters. It is also
possible to use artificial promoters. It will be appreciated by
those of ordinary skill in the art that the design of the
expression vector can depend on such factors as the choice of the
host cell to be transformed, the level of expression of protein
desired, etc. The expression vectors of the invention can be
introduced into host cells to thereby produce proteins or peptides,
including fusion proteins or peptides, encoded by nucleic acids as
described herein (e.g., MCP proteins, mutant forms of MCP proteins,
fusion proteins, etc.).
[0081] The recombinant expression vectors of the invention can be
designed for expression of MCP proteins in prokaryotic or
eukaryotic cells. For example, MCP genes can be expressed in
bacterial cells such as C. glutamicum, insect cells (using
baculovirus expression vectors), yeast and other fungal cells (see
Romanos, M. A. et al. (1992) "Foreign gene expression in yeast: a
review", Yeast 8: 423-488; van den Hondel, C. A. M. J. J. et al.
(1991) "Heterologous gene expression in filamentous fungi" in: More
Gene Manipulations in Fungi, J. W. Bennet & L. L. Lasure, eds.,
p. 396-428: Academic Press: San Diego; and van den Hondel, C. A. M.
J. J. & Punt, P. J. (1991) "Gene transfer systems and vector
development for filamentous fungi, in: Applied Molecular Genetics
of Fungi, Peberdy, J. F. et al., eds., p. 1-28, Cambridge
University Press: Cambridge), algae and multicellular plant cells
(see Schmidt, R. and Willmitzer, L. (1988) High efficiency
Agrobacterium tumefactiens-mediated transformation of Arabidopsis
thaliana leaf and cotyledon explants" Plant Cell Rep.: 583-586), or
mammalian cells. Suitable host cells are discussed further in
Goeddel, Gene Expression Technology: Methods in Enzymology 185,
Academic Press, San Diego, Calif. (1990). Alternatively, the
recombinant expression vector can be transcribed and translated in
vitro, for example using T7 promoter regulatory sequences and T7
polymerase.
[0082] Expression of proteins in prokaryotes is most often carried
out with vectors containing constitutive or inducible promoters
directing the expression of either fusion or non-fusion proteins.
Fusion vectors add a number of amino acids to a protein encoded
therein, usually to the amino terminus of the recombinant protein.
Such fusion vectors typically serve three purposes: 1) to increase
expression of recombinant protein; 2) to increase the solubility of
the recombinant protein; and 3) to aid in the purification of the
recombinant protein by acting as a ligand in affinity purification.
Often, in fusion expression vectors, a proteolytic cleavage site is
introduced at the junction of the fusion moiety and the recombinant
protein to enable separation of the recombinant protein from the
fusion moiety subsequent to purification of the fusion protein.
Such enzymes, and their cognate recognition sequences, include
Factor Xa, thrombin and enterokinase.
[0083] Typical fusion expression vectors include pGEX (Pharmacia
Biotech Inc; Smith, D. B. and Johnson, K. S. (1988) Gene 67:31-40),
pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia,
Piscataway, N.J.) which fuse glutathione S-transferase (GST),
maltose E binding protein, or protein A, respectively, to the
target recombinant protein. In one embodiment, the coding sequence
of the MCP protein is cloned into a pGEX expression vector to
create a vector encoding a fusion protein comprising, from the
N-terminus to the C-terminus, GST-thrombin cleavage site-X protein.
The fusion protein can be purified by affinity chromatography using
glutathione-agarose resin. Recombinant MCP protein unfused to GST
can be recovered by cleavage of the fusion protein with
thrombin.
[0084] Examples of suitable inducible non-fusion E. coli expression
vectors include pTrc (Amann et al., (1988) Gene 69:301-315),
pLG338, pACYC184, pBR322, pUC18, pUC19, pKC30, pRep4, pHS1, pHS2,
pPLc236, pMBL24, pLG200, pUR290, pIN-III113-B1, .lamda.gt11, pBdCl,
and pET 11d (Studier et al., Gene Expression Technology: Methods in
Enzymology 185, Academic Press, San Diego, Calif. (1990) 60-89; and
Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York
IBSN 0 444 904018). Target gene expression from the pTrc vector
relies on host RNA polymerase transcription from a hybrid trp-lac
fusion promoter. Target gene expression from the pET 11d vector
relies on transcription from a T7 gn10-lac fusion promoter mediated
by a coexpressed viral RNA polymerase (T7 gn1). This viral
polymerase is supplied by host strains BL21 (DE3) or HMS174(DE3)
from a resident .lamda. prophage harboring a T7 gn1 gene under the
transcriptional control of the lacUV 5 promoter. For transformation
of other varieties of bacteria, appropriate vectors may be
selected. For example, the plasmids pIJ101, pIJ364, pIJ702 and
pIJ361 are known to be useful in transforming Streptomyces, while
plasmids pUB110, pC194, or pBD214 are suited for transformation of
Bacillus species. Several plasmids of use in the transfer of
genetic information into Corynebacterium include pHM1519, pBL1,
pSA77, or pAJ667 (Pouwels et al., eds. (1985) Cloning Vectors.
Elsevier: New York IBSN 0 444 904018).
[0085] One strategy to maximize recombinant protein expression is
to express the protein in a host bacteria with an impaired capacity
to proteolytically cleave the recombinant protein (Gottesman, S.,
Gene Expression Technology: Methods in Enzymology 185, Academic
Press, San Diego, Calif. (1990) 119-128). Another strategy is to
alter the nucleic acid sequence of the nucleic acid to be inserted
into an expression vector so that the individual codons for each
amino acid are those preferentially utilized in the bacterium
chosen for expression, such as C. glutamicum (Wada et al. (1992)
Nucleic Acids Res. 20:2111-2118). Such alteration of nucleic acid
sequences of the invention can be carried out by standard DNA
synthesis techniques.
[0086] In another embodiment, the MCP protein expression vector is
a yeast expression vector. Examples of vectors for expression in
yeast S. cerevisiae include pYepSec1 (Baldari, et al., (1987) Embo
J. 6:229-234), 2.mu., pAG-1, Yep6, Yep13, pEMBL Ye23, pMFa (Kurjan
and Herskowitz, (1982) Cell 30:933-943), pJRY88 (Schultz et al.,
(1987) Gene 54:113-123), and pYES2 (Invitrogen Corporation, San
Diego, Calif.). Vectors and methods for the construction of vectors
appropriate for use in other fungi, such as the filamentous fungi,
include those detailed in: van den Hondel, C. A. M. J. J. &
Punt, P. J. (1991) "Gene transfer systems and vector development
for filamentous fungi, in: Applied Molecular Genetics of Fungi, J.
F. Peberdy, et al., eds., p. 1-28, Cambridge University Press:
Cambridge, and Pouwels et al., eds. (1985) Cloning Vectors.
Elsevier: New York (IBSN 0 444 904018).
[0087] Alternatively, the MCP proteins of the invention can be
expressed in insect cells using baculovirus expression vectors.
Baculovirus vectors available for expression of proteins in
cultured insect cells (e.g., Sf 9 cells) include the pAc series
(Smith et al. (1983) Mol. Cell Biol. 3:2156-2165) and the pVL
series (Lucklow and Summers (1989) Virology 170:31-39).
[0088] In another embodiment, the MCP proteins of the invention may
be expressed in unicellular plant cells (such as algae) or in plant
cells from higher plants (e.g., the spermatophytes, such as crop
plants). Examples of plant expression vectors include those
detailed in: Becker, D., Kemper, E., Schell, J. and Masterson, R.
(1992) "New plant binary vectors with selectable markers located
proximal to the left border", Plant Mol. Biol. 20: 1195-1197; and
Bevan, M. W. (1984) "Binary Agrobacterium vectors for plant
transformation", Nuc. Acid. Res. 12: 8711-8721, and include pLGV23,
pGHlac+, pBIN19, pAK2004, and pDH51 (Pouwels et al., eds. (1985)
Cloning Vectors. Elsevier: New York IBSN 0 444 904018).
[0089] In yet another embodiment, a nucleic acid of the invention
is expressed in mammalian cells using a mammalian expression
vector. Examples of mammalian expression vectors include pCDM8
(Seed, B. (1987) Nature 329:840) and pMT2PC (Kaufman et al. (1987)
EMBO J. 6:187-195). When used in mammalian cells, the expression
vector's control-functions are often provided by viral regulatory
elements. For example, commonly used promoters are derived from
polyoma, Adenovirus 2, cytomegalovirus and Simian Virus 40. For
other suitable expression systems for both prokaryotic and
eukaryotic cells see chapters 16 and 17 of Sambrook, J., Fritsh, E.
F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd,
ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory
Press, Cold Spring Harbor, N.Y., 1989.
[0090] In another embodiment, the recombinant mammalian expression
vector is capable of directing expression of the nucleic acid
preferentially in a particular cell type (e.g., tissue-specific
regulatory elements are used to express the nucleic acid).
Tissue-specific regulatory elements are known in the art.
Non-limiting examples of suitable tissue-specific promoters include
the albumin promoter (liver-specific; Pinkert et al. (1987) Genes
Dev. 1:268-277), lymphoid-specific promoters (Calame and Eaton
(1988) Adv. Immunol. 43:235-275), in particular promoters of T cell
receptors (Winoto and Baltimore (1989) EMBO J. 8:729-733) and
immunoglobulins (Banerji et al. (1983) Cell 33:729-740; Queen and
Baltimore (1983) Cell 33:741-748), neuron-specific promoters (e.g.,
the neurofilament promoter; Byrne and Ruddle (1989) PNAS
86:5473-5477), pancreas-specific promoters (Edlund et al. (1985)
Science 230:912-916), and mammary gland-specific promoters (e.g.,
milk whey promoter; U.S. Pat. No. 4,873,316 and European
Application Publication No. 264,166). Developmentally-regulated
promoters are also encompassed, for example the murine hox
promoters (Kessel and Gruss (1990) Science 249:374-379) and the
.alpha.-fetoprotein promoter (Campes and Tilghman (1989) Genes Dev.
3:537-546).
[0091] The invention further provides a recombinant expression
vector comprising a DNA molecule of the invention cloned into the
expression vector in an antisense orientation. That is, the DNA
molecule is operatively linked to a regulatory sequence in a manner
which allows for expression (by transcription of the DNA molecule)
of an RNA molecule which is antisense to MCP mRNA. Regulatory
sequences operatively linked to a nucleic acid cloned in the
antisense orientation can be chosen which direct the continuous
expression of the antisense RNA molecule in a variety of cell
types, for instance viral promoters and/or enhancers, or regulatory
sequences can be chosen which direct constitutive, tissue specific
or cell type specific expression of antisense RNA. The antisense
expression vector can be in the form of a recombinant plasmid,
phagemid or attenuated virus in which antisense nucleic acids are
produced under the control of a high efficiency regulatory region,
the activity of which can be determined by the cell type into which
the vector is introduced. For a discussion of the regulation of
gene expression using antisense genes see Weintraub, H. et al.
(1986) "Antisense RNA as a molecular tool for genetic analysis",
Reviews--Trends in Genetics, Vol. 1(1).
[0092] Another aspect of the invention pertains to host cells into
which a recombinant expression vector of the invention has been
introduced. The terms "host cell" and "recombinant host cell" are
used interchangeably herein. It is understood that such terms refer
not only to the particular subject cell but to the progeny or
potential progeny of such a cell. Because certain modifications may
occur in succeeding generations due to either mutation or
environmental influences, such progeny may not, in fact, be
identical to the parent cell, but are still included within the
scope of the term as used herein.
[0093] A host cell can be any prokaryotic or eukaryotic cell. For
example, an MCP protein can be expressed in bacterial cells such as
C. glutamicum, insect cells, yeast or mammalian cells (such as
Chinese hamster ovary cells (CHO) or COS cells). Other suitable
host cells are known to those of ordinary skill in the art.
Microorganisms related to Corynebacterium glutamicum which may be
conveniently used as host cells for the nucleic acid and protein
molecules of the invention are set forth in Table 3.
[0094] Vector DNA can be introduced into prokaryotic or eukaryotic
cells via conventional transformation or transfection techniques.
As used herein, the terms "transformation", "transfection",
"conjugation" and "transduction" are intended to refer to a variety
of art-recognized techniques for introducing foreign nucleic acid
(e.g., linear DNA or RNA (e.g., a linearized vector or a gene
construct alone without a vector) or nucleic acid in the form of a
vector (e.g., a plasmid, phage, phasmid, phagemid, transposon or
other DNA) into a host cell, including using natural competence,
chemical mediated transfer, calcium phosphate or calcium chloride
co-precipitation, DEAE-dextran-mediated transfection, lipofection,
or electroporation. Suitable methods for transforming or
transfecting host cells can be found in Sambrook, et al. (Molecular
Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor
Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring
Harbor, N.Y., 1989), and other laboratory manuals.
[0095] For stable transfection of mammalian cells, it is known
that, depending upon the expression vector and transfection
technique used, only a small fraction of cells may integrate the
foreign DNA into their genome. In order to identify and select
these integrants, a gene that encodes a selectable marker (e.g.,
resistance to antibiotics) is generally introduced into the host
cells along with the gene of interest. Preferred selectable markers
include those which confer resistance to drugs, such as G418,
hygromycin and methotrexate. Nucleic acid encoding a selectable
marker can be introduced into a host cell on the same vector as
that encoding an MCP protein or can be introduced on a separate
vector. Cells stably transfected with the introduced nucleic acid
can be identified by, for example, drug selection (e.g., cells that
have incorporated the selectable marker gene will survive, while
the other cells die).
[0096] To create a homologous recombinant microorganism, a vector
is prepared which contains at least a portion of an MCP gene into
which a deletion, addition or substitution has been introduced to
thereby alter, e.g., functionally disrupt, the MCP gene.
Preferably, this MCP gene is a Corynebacterium glutamicum MCP gene,
but it can be a homologue from a related bacterium or even from a
mammalian, yeast, or insect source. In a preferred embodiment, the
vector is designed such that, upon homologous recombination, the
endogenous MCP gene is functionally disrupted (i.e., no longer
encodes a functional protein; also referred to as a "knock out"
vector). Alternatively, the vector can be designed such that, upon
homologous recombination, the endogenous MCP gene is mutated or
otherwise altered but still encodes functional protein (e.g., the
upstream regulatory region can be altered to thereby alter the
expression of the endogenous MCP protein). In the homologous
recombination vector, the altered portion of the MCP gene is
flanked at its 5' and 3' ends by additional nucleic acid of the MCP
gene to allow for homologous recombination to occur between the
exogenous MCP gene carried by the vector and an endogenous MCP gene
in a microorganism. The additional flanking MCP nucleic acid is of
sufficient length for successful homologous recombination with the
endogenous gene. Typically, less than one kilobase of flanking DNA
(both at the 5' and 3' ends) is included in the vector (see e.g.,
Thomas, K. R., and Capecchi, M. R. (1987) Cell 51: 503 for a
description of homologous recombination vectors). The vector is
introduced into a microorganism (e.g., by electroporation) and
cells in which the introduced MCP gene has homologously recombined
with the endogenous MCP gene are selected, using art-known
techniques.
[0097] In another embodiment, recombinant microorganisms can be
produced which contain selected systems which allow for regulated
expression of the introduced gene. For example, inclusion of an MCP
gene on a vector placing it under control of the lac operon permits
expression of the MCP gene in the presence of IPTG. Such regulatory
systems are well known in the art.
[0098] In another embodiment, an endogenous MCP gene in a host cell
is disrupted (e.g., by homologous recombination or other genetic
means known in the art) such that expression of its protein product
does not occur. In another embodiment, an endogenous or introduced
MCP gene in a host cell has been altered by one or more point
mutations, deletions, or inversions, but still encodes a functional
MCP protein. In still another embodiment, one or more of the
regulatory regions (e.g., a promoter, repressor, or inducer) of an
MCP gene in a microorganism has been altered (e.g., by deletion,
truncation, inversion, or point mutation) such that the expression
of the MCP gene is modulated. One of ordinary skill in the art will
appreciate that host cells containing more than one of the
described MCP gene and protein modifications may be readily
produced using the methods of the invention, and are meant to be
included in the present invention.
[0099] A host cell of the invention, such as a prokaryotic or
eukaryotic host cell in culture, can be used to produce (i.e.,
express) an MCP protein. Accordingly, the invention further
provides methods for producing MCP proteins using the host cells of
the invention. In one embodiment, the method comprises culturing
the host cell of invention (into which a recombinant expression
vector encoding an MCP protein has been introduced, or into which
genome has been introduced a gene encoding a wild-type or altered
MCP protein) in a suitable medium until MCP protein is produced. In
another embodiment, the method further comprises isolating MCP
proteins from the medium or the host cell.
C. Isolated MCP Proteins
[0100] Another aspect of the invention pertains to isolated MCP
proteins, and biologically active portions thereof. An "isolated"
or "purified" protein or biologically active portion thereof is
substantially free of cellular material when produced by
recombinant DNA techniques, or chemical precursors or other
chemicals when chemically synthesized. The language "substantially
free of cellular material" includes preparations of MCP protein in
which the protein is separated from cellular components of the
cells in which it is naturally or recombinantly produced. In one
embodiment, the language "substantially free of cellular material"
includes preparations of MCP protein having less than about 30% (by
dry weight) of non-MCP protein (also referred to herein as a
"contaminating protein"), more preferably less than about 20% of
non-MCP protein, still more preferably less than about 10% of
non-MCP protein, and most preferably less than about 5% non-MCP
protein. When the MCP protein or biologically active portion
thereof is recombinantly produced, it is also preferably
substantially free of culture medium, i.e., culture medium
represents less than about 20%, more preferably less than about
10%, and most preferably less than about 5% of the volume of the
protein preparation. The language "substantially free of chemical
precursors or other chemicals" includes preparations of MCP protein
in which the protein is separated from chemical precursors or other
chemicals which are involved in the synthesis of the protein. In
one embodiment, the language "substantially free of chemical
precursors or other chemicals" includes preparations of MCP protein
having less than about 30% (by dry weight) of chemical precursors
or non-MCP chemicals, more preferably less than about 20% chemical
precursors or non-MCP chemicals, still more preferably less than
about 10% chemical precursors or non-MCP chemicals, and most
preferably less than about 5% chemical precursors or non-MCP
chemicals. In preferred embodiments, isolated proteins or
biologically active portions thereof lack contaminating proteins
from the same organism from which the MCP protein is derived.
Typically, such proteins are produced by recombinant expression of,
for example, a C. glutamicum MCP protein in a microorganism such as
C. glutamicum.
[0101] An isolated MCP protein or a portion thereof of the
invention is able to modulate the yield, production, and/or
efficiency of production of one or more fine chemicals from C.
glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to
serve as a target for drug development, or to serve as an
identifying marker for C. glutamicum or related organisms. In
preferred embodiments, the protein or portion thereof comprises an
amino acid sequence which is sufficiently homologous to an amino
acid sequence of Appendix B such that the protein or portion
thereof maintains the ability to modulate the yield, production,
and/or efficiency of production of one or more fine chemicals from
C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to
serve as a target for drug development, or to serve as an
identifying marker for C. glutamicum or related organisms. The
portion of the protein is preferably a biologically active portion
as described herein. In another preferred embodiment, an MCP
protein of the invention has an amino acid sequence shown in
Appendix B. In yet another preferred embodiment, the MCP protein
has an amino acid sequence which is encoded by a nucleotide
sequence which hybridizes, e.g., hybridizes under stringent
conditions, to a nucleotide sequence of Appendix A. In still
another preferred embodiment, the MCP protein has an amino acid
sequence which is encoded by a nucleotide sequence that is at least
about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%,
preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%,
69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%,
75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%,
88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably
at least about 95%, 96%, 97%, 98%, 99% or more homologous to one of
the nucleic acid sequences of Appendix A, or a portion thereof.
Ranges and identity values intermediate to the above-recited
values, (e.g., 70-90% identical or 80-95% identical) are also
intended to be encompassed by the present invention. For example,
ranges of identity values using a combination of any of the above
values recited as upper and/or lower limits are intended to be
included. The preferred MCP proteins of the present invention also
preferably possess at least one of the MCP activities described
herein. For example, a preferred MCP protein of the present
invention includes an amino acid sequence encoded by a nucleotide
sequence which hybridizes, e.g., hybridizes under stringent
conditions, to a nucleotide sequence of Appendix A, and which is
able to modulate the yield, production, and/or efficiency of
production of one or more fine chemicals from C. glutamicum, to
degrade hydrocarbons, to oxidize terpenoids, to serve as a target
for drug development, or to serve as an identifying marker for C.
glutamicum or related organisms.
[0102] In other embodiments, the MCP protein is substantially
homologous to an amino acid sequence of Appendix B and retains the
functional activity of the protein of one of the sequences of
Appendix B yet differs in amino acid sequence due to natural
variation or mutagenesis, as described in detail in subsection I
above. Accordingly, in another embodiment, the MCP protein is a
protein which comprises an amino acid sequence which is at least
about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%,
preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%,
69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%,
75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%,
88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably
at least about 95%, 96%, 97%, 98%, 99% or more homologous to an
entire amino acid sequence of Appendix B and which has at least one
of the MCP activities described herein. Ranges and identity values
intermediate to the above-recited values, (e.g., 70-90% identical
or 80-95% identical) are also intended to be encompassed by the
present invention. For example, ranges of identity values using a
combination of any of the above values recited as upper and/or
lower limits are intended to be included. In another embodiment,
the invention pertains to a full length C. glutamicum protein which
is substantially homologous to an entire amino acid sequence of
Appendix B.
[0103] Biologically active portions of an MCP protein include
peptides comprising amino acid sequences derived from the amino
acid sequence of an MCP protein, e.g., an amino acid sequence shown
in Appendix B or the amino acid sequence of a protein homologous to
an MCP protein, which include fewer amino acids than a full length
MCP protein or the full length protein which is homologous to an
MCP protein, and exhibit at least one activity of an MCP protein.
Typically, biologically active portions (peptides, e.g., peptides
which are, for example, 5, 10, 15, 20, 30, 35, 36, 37, 38, 39, 40,
50, 100 or more amino acids in length) comprise a domain or motif
with at least one activity of an MCP protein. Moreover, other
biologically active portions, in which other regions of the protein
are deleted, can be prepared by recombinant techniques and
evaluated for one or more of the activities described herein.
Preferably, the biologically active portions of an MCP protein
include one or more selected domains/motifs or portions thereof
having biological activity.
[0104] MCP proteins are preferably produced by recombinant DNA
techniques. For example, a nucleic acid molecule encoding the
protein is cloned into an expression vector (as described above),
the expression vector is introduced into a host cell (as described
above) and the MCP protein is expressed in the host cell. The MCP
protein can then be isolated from the cells by an appropriate
purification scheme using standard protein purification techniques.
Alternative to recombinant expression, an MCP protein, polypeptide,
or peptide can be synthesized chemically using standard peptide
synthesis techniques. Moreover, native MCP protein can be isolated
from cells (e.g., endothelial cells, bacterial cells, fungal cells
or other cells), for example using an anti-MCP antibody, which can
be produced by standard techniques utilizing an MCP protein or
fragment thereof of this invention.
[0105] The invention also provides MCP chimeric or fusion proteins.
As used herein, an MCP "chimeric protein" or "fusion protein"
comprises an MCP polypeptide operatively linked to a non-MCP
polypeptide. An "MCP polypeptide" refers to a polypeptide having an
amino acid sequence corresponding to an MCP protein, whereas a
"non-MCP polypeptide" refers to a polypeptide having an amino acid
sequence corresponding to a protein which is not substantially
homologous to the MCP protein, e.g., a protein which is different
from the MCP protein and which is derived from the same or a
different organism. Within the fusion protein, the term
"operatively linked" is intended to indicate that the MCP
polypeptide and the non-MCP polypeptide are fused in-frame to each
other. The non-MCP polypeptide can be fused to the N-terminus or
C-terminus of the MCP polypeptide. For example, in one embodiment
the fusion protein is a GST-MCP fusion protein in which the MCP
sequences are fused to the C-terminus of the GST sequences. Such
fusion proteins can facilitate the purification of recombinant MCP
proteins. In another embodiment, the fusion protein is an MCP
protein containing a heterologous signal sequence at its
N-terminus. In certain host cells (e.g., mammalian host cells,
bacterial host cells, fungal host cells), expression and/or
secretion of an MCP protein can be increased through use of a
heterologous signal sequence.
[0106] Preferably, an MCP chimeric or fusion protein of the
invention is produced by standard recombinant DNA techniques. For
example, DNA fragments coding for the different polypeptide
sequences are ligated together in-frame in accordance with
conventional techniques, for example by employing blunt-ended or
stagger-ended termini for ligation, restriction enzyme digestion to
provide for appropriate termini, filling-in of cohesive ends as
appropriate, alkaline phosphatase treatment to avoid undesirable
joining, and enzymatic ligation. In another embodiment, the fusion
gene can be synthesized by conventional techniques including
automated DNA synthesizers. Alternatively, PCR amplification of
gene fragments can be carried out using anchor primers which give
rise to complementary overhangs between two consecutive gene
fragments which can subsequently be annealed and reamplified to
generate a chimeric gene sequence (see, for example, Current
Protocols in Molecular Biology, eds. Ausubel et al. John Wiley
& Sons: 1992). Moreover, many expression vectors are
commercially available that already encode a fusion moiety (e.g., a
GST polypeptide). An MCP-encoding nucleic acid can be cloned into
such an expression vector such that the fusion moiety is linked
in-frame to the MCP protein.
[0107] Homologues of the MCP protein can be generated by
mutagenesis, e.g., discrete point mutation or truncation of the MCP
protein. As used herein, the term "homologue" refers to a variant
form of the MCP protein which acts as an agonist or antagonist of
the activity of the MCP protein. An agonist of the MCP protein can
retain substantially the same, or a subset, of the biological
activities of the MCP protein. An antagonist of the MCP protein can
inhibit one or more of the activities of the naturally occurring
form of the MCP protein, by, for example, competitively binding to
a downstream or upstream member of a biochemical pathway which
includes the MCP protein.
[0108] In an alternative embodiment, homologues of the MCP protein
can be identified by screening combinatorial libraries of mutants,
e.g., truncation mutants, of the MCP protein for MCP protein
agonist or antagonist activity. In one embodiment, a variegated
library of MCP variants is generated by combinatorial mutagenesis
at the nucleic acid level and is encoded by a variegated gene
library. A variegated library of MCP variants can be produced by,
for example, enzymatically ligating a mixture of synthetic
oligonucleotides into gene sequences such that a degenerate set of
potential MCP sequences is expressible as individual polypeptides,
or alternatively, as a set of larger fusion proteins (e.g., for
phage display) containing the set of MCP sequences therein. There
are a variety of methods which can be used to produce libraries of
potential MCP homologues from a degenerate oligonucleotide
sequence. Chemical synthesis of a degenerate gene sequence can be
performed in an automatic DNA synthesizer, and the synthetic gene
then ligated into an appropriate expression vector. Use of a
degenerate set of genes allows for the provision, in one mixture,
of all of the sequences encoding the desired set of potential MCP
sequences. Methods for synthesizing degenerate oligonucleotides are
known in the art (see, e.g., Narang, S. A. (1983) Tetrahedron 39:3;
Itakura et al. (1984) Annu. Rev. Biochem. 53:323; Itakura et al.
(1984) Science 198:1056; Ike et al. (1983) Nucleic Acid Res.
11:477.
[0109] In addition, libraries of fragments of the MCP protein
coding can be used to generate a variegated population of MCP
fragments for screening and subsequent selection of homologues of
an MCP protein. In one embodiment, a library of coding sequence
fragments can be generated by treating a double stranded PCR
fragment of an MCP coding sequence with a nuclease under conditions
wherein nicking occurs only about once per molecule, denaturing the
double stranded DNA, renaturing the DNA to form double stranded DNA
which can include sense/antisense pairs from different nicked
products, removing single stranded portions from reformed duplexes
by treatment with S1 nuclease, and ligating the resulting fragment
library into an expression vector. By this method, an expression
library can be derived which encodes N-terminal, C-terminal and
internal fragments of various sizes of the MCP protein.
[0110] Several techniques are known in the art for screening gene
products of combinatorial libraries made by point mutations or
truncation, and for screening cDNA libraries for gene products
having a selected property. Such techniques are adaptable for rapid
screening of the gene libraries generated by the combinatorial
mutagenesis of MCP homologues. The most widely used techniques,
which are amenable to high through-put analysis, for screening
large gene libraries typically include cloning the gene library
into replicable expression vectors, transforming appropriate cells
with the resulting library of vectors, and expressing the
combinatorial genes under conditions in which detection of a
desired activity facilitates isolation of the vector encoding the
gene whose product was detected. Recrusive ensemble mutagenesis
(REM), a new technique which enhances the frequency of functional
mutants in the libraries, can be used in combination with the
screening assays to identify MCP homologues (Arkin and Yourvan
(1992) PNAS 89:7811-7815; Delgrave et al. (1993) Protein
Engineering 6(3):327-331).
[0111] In another embodiment, cell based assays can be exploited to
analyze a variegated MCP library, using methods well known in the
art.
D. Uses and Methods of the Invention
[0112] The nucleic acid molecules, proteins, protein homologues,
fusion proteins, primers, vectors, and host cells described herein
can be used in one or more of the following methods: identification
of C. glutamicum and related organisms; mapping of genomes of
organisms related to C. glutamicum; identification and localization
of C. glutamicum sequences of interest; evolutionary studies;
determination of MCP protein regions required for function;
modulation of an MCP protein activity; modulation of the activity
of one or more metabolic pathways; and modulation of cellular
production of a desired compound, such as a fine chemical.
[0113] The MCP nucleic acid molecules of the invention have a
variety of uses. First, they may be used to identify an organism as
being Corynebacterium glutamicum or a close relative thereof. Also,
they may be used to identify the presence of C. glutamicum or a
relative thereof in a mixed population of microorganisms. The
invention provides the nucleic acid sequences of a number of C.
glutamicum genes, and probes based thereon; by probing the
extracted genomic DNA of a culture of a unique or mixed population
of microorganisms under stringent conditions with a probe spanning
a region of a C. glutamicum gene which is unique to this organism,
one can ascertain whether this organism is present. Although
Corynebacterium glutamicum itself is nonpathogenic, it is related
to pathogenic species, such as Corynebacterium diphtheriae.
Corynebacterium diphtheriae is the causative agent of diphtheria, a
rapidly developing, acute, febrile infection which involves both
local and systemic pathology. In this disease, a local lesion
develops in the upper respiratory tract and involves necrotic
injury to epithelial cells; the bacilli secrete toxin which is
disseminated through this lesion to distal susceptible tissues of
the body. Degenerative changes brought about by the inhibition of
protein synthesis in these tissues, which include heart, muscle,
peripheral nerves, adrenals, kidneys, liver and spleen, result in
the systemic pathology of the disease. Diphtheria continues to have
high incidence in many parts of the world, including Africa, Asia,
Eastern Europe and the independent states of the former Soviet
Union. An ongoing epidemic of diphtheria in the latter two regions
has resulted in at least 5,000 deaths since 1990.
[0114] In one embodiment, the invention provides a method of
identifying the presence or activity of Corynebacterium diphtheriae
in a subject. This method includes detection of one or more of the
nucleic acid or amino acid sequences of the invention (e.g., the
sequences set forth in Appendix A or Appendix B) in a subject,
thereby detecting the presence or activity of Corynebacterium
diphtheriae in the subject. C. glutamicum and C. diphtheriae are
related bacteria, and many of the nucleic acid and protein
molecules in C. glutamicum are homologous to C. diphtheriae nucleic
acid and protein molecules, and can therefore be used to detect C.
diphtheriae in a subject.
[0115] To detect the presence of C. glutamicum in a sample,
techniques well known in the art may be employed. Specifically, the
cells in the sample may optionally first be cultured in a suitable
liquid or on a suitable solid culture medium to increase the number
of cells in the sample. These cells are lysed, and the total DNA
content extracted and optionally purified to remove debris and
protein material which may interfere with subsequent analysis. The
polymerase chain reaction or a similar technique known in the art
is performed (for general reference on methodologies commonly used
for the amplification of nucleic acid sequences, see Mullis et al.,
U.S. Pat. No. 4,683,195, Mullis et al., U.S. Pat. No. 4,965,188,
and Innis, M. A., and Gelfand, D. H., (1989) PCR Protocols, A guide
to Methods and Applications, Academic Press, p. 3-12, and (1988)
Biotechnology 6:1197, and International Patent Application No.
WO89/01050) in which primers specific to an MCP nucleic acid
molecule of the invention are incubated with the nucleic acid
sample such that, if present in the sample, that particular MCP
nucleic acid sequence will be amplified. The particular MCP nucleic
acid to be amplified is selected based on its uniqueness to the C.
glutamicum genome, or to the genomes of C. glutamicum and only a
few closely related bacteria. The presence of the desired amplified
product is thus indicative of the presence of C. glutamicum, or an
organism closely related to C. glutamicum.
[0116] Further, the nucleic acid and protein molecules of the
invention may serve as markers for specific regions of the genome.
It is possible, using techniques well known in the art, to
ascertain the physical location on the C. glutamicum genome of the
MCP nucleic acid molecules of the invention, which in turn provides
markers on the genome which can be used to aid in the placement of
other nucleic acid molecules and genes on the genome map. Also, the
nucleic acid molecules of the invention may be sufficiently
homologous to the sequences of related bacterial species that these
nucleic acid molecules may similarly permit the construction of a
genomic map in such bacteria (e.g., Brevibacterium
lactofermentum).
[0117] The nucleic acid molecules of the invention have utility not
only in the mapping of the genome, but also for functional studies
of C. glutamicum proteins. For example, to identify the region of
the genome to which a particular C. glutamicum DNA-binding protein
binds, the C. glutamicum genome could be digested, and the
fragments incubated with the DNA-binding protein. Those which bind
the protein may be additionally probed with the nucleic acid
molecules of the invention, preferably with readily detectable
labels; binding of such a nucleic acid molecule to the genome
fragment enables the localization of the fragment to the genome map
of C. glutamicum, and, when performed multiple times with different
enzymes, facilitates a rapid determination of the nucleic acid
sequence to which the protein binds.
[0118] The MCP nucleic acid molecules of the invention are also
useful for evolutionary and protein structural studies. The
metabolic processes in which the molecules of the invention
participate are utilized by a wide variety of prokaryotic and
eukaryotic cells; by comparing the sequences of the nucleic acid
molecules of the present invention to those encoding similar
enzymes from other organisms, the evolutionary relatedness of the
organisms can be assessed. Similarly, such a comparison permits an
assessment of which regions of the sequence are conserved and which
are not, which may aid in determining those regions of the protein
which are essential for the functioning of the enzyme. This type of
determination is of value for protein engineering studies and may
give an indication of what the protein can tolerate in terms of
mutagenesis without losing function.
[0119] The MCP protein molecules of the invention may also be
utilized as markers for the classification of an unknown bacterium
as C. glutamicum, or for the identification of C. glutamicum or
closely related bacteria in a sample. For example, using techniques
well known in the art, cells in a sample may optionally be
amplified (e.g., by culturing in an appropriate medium) to increase
the sample size, and then may be lysed to release proteins
contained therein. This sample may optionally be purified to remove
debris and nucleic acid molecules which may interfere with
subsequent analysis. Antibodies specific for a selected MCP protein
of the invention may be incubated with the protein sample in a
typical Western assay format (see, e.g., Ausubel et al., (1988)
Current Protocols in Molecular Biology, Wiley: New York) in which
the antibody will bind to its target protein if this protein is
present in the sample. An MCP protein is selected for this type of
assay if it is unique or nearly unique to C. glutamicum or C.
glutamicum and bacteria very closely related to C. glutamicum.
Proteins in the sample are then separated by gel electrophoresis,
and transferred to a suitable matrix, such as nitrocellulose. An
appropriate secondary antibody having a detectable label (e.g.,
chemiluminescent or colorimetric) is incubated with this matrix,
followed by stringent washing. The presence or absence of the label
is indicative of the presence or absence of the target protein in
the sample. If the protein is present, then this is indicative of
the presence of C. glutamicum. A similar process enables the
classification of an unknown bacterium as C. glutamicum; if a panel
of proteins specific to C. glutamicum are not detected in protein
samples prepared from the unknown bacterium, then that bacterium is
not likely to be C. glutamicum.
[0120] The invention provides methods for screening molecules which
modulate the activity of an MCP protein, either by interacting with
the protein itself or a substrate or binding partner of the MCP
protein, or by modulating the transcription or translation of an
MCP nucleic acid molecule of the invention. In such methods, a
microorganism expressing one or more MCP proteins of the invention
is contacted with one or more test compounds, and the effect of
each test compound on the activity or level of expression of the
MCP protein is assessed.
[0121] Genetic manipulation of the MCP nucleic acid molecules of
the invention may result in the production of MCP proteins having
functional differences from the wild-type MCP proteins. These
proteins may be improved in efficiency or activity, may be present
in greater numbers in the cell than is usual, or may be decreased
in efficiency or activity.
[0122] Such changes in activity may directly modulate the yield,
production, and/or efficiency of production of one or more fine
chemicals from C. glutamicum. For example, by modifying the
activity of a protein involved in the biosynthesis or degradation
of a fine chemical (i.e., through mutagenesis of the corresponding
gene), one may directly modulate the ability of the cell to
synthesize or to degrade this compound, thereby modulating the
yield and/or efficiency of production of the fine chemical.
Similarly, by modulating the activity of a protein which regulates
a fine chemical metabolic pathway, one may directly influence
whether the production of the desired compound is up- or
down-regulated, either of which will modulate the yield or
efficiency of production of the fine chemical from the cell.
[0123] Indirect modulation of fine chemical production may also
result by modifying the activity of a protein of the invention
(i.e., by mutagenesis of the corresponding gene) such that the
overall ability of the cell to grow and divide or to remain viable
and productive is increased. The production of fine chemicals from
C. glutamicum is generally accomplished by the large-scale
fermentative culture of these microorganisms, conditions which are
frequently suboptimal for growth and cell division. By engineering
a protein of the invention (e.g., a stress response protein, a cell
wall protein, or proteins involved in the metabolism of compounds
necessary for cell growth and division to occur, such as
nucleotides and amino acids) such that it is better able to
survive, grow, and multiply in such conditions, it may be possible
to increase the number and productivity of such engineered C.
glutamicum cells in large-scale culture, which in turn should
result in increased yields and/or efficiency of production of one
or more desired fine chemicals. Further, the metabolic pathways of
any cell are necessarily interrelated and coregulated. By altering
the activity or regulation of any one metabolic pathway in C.
glutamicum (i.e., by altering the activity of one of the proteins
of the invention which participates in such a pathway), it is
possible to concomitantly alter the activity or regulation of other
metabolic pathways in this microorganism, which may be directly
involved in the synthesis or degradation of a fine chemical.
[0124] The aforementioned mutagenesis strategies for MCP proteins
to result in increased yields of a fine chemical from C. glutamicum
are not meant to be limiting; variations on these strategies will
be readily apparent to one of ordinary skill in the art. Using such
strategies, and incorporating the mechanisms disclosed herein, the
nucleic acid and protein molecules of the invention may be utilized
to generate C. glutamicum or related strains of bacteria expressing
mutated MCP nucleic acid and protein molecules such that the yield,
production, and/or efficiency of production of a desired compound
is improved. This desired compound may be any natural product of C.
glutamicum, which includes the final products of biosynthesis
pathways and intermediates of naturally-occurring metabolic
pathways, as well as molecules which do not naturally occur in the
metabolism of C. glutamicum, but which are produced by a C.
glutamicum strain of the invention.
[0125] This invention is further illustrated by the following
examples which should not be construed as limiting. The contents of
all references, patent applications, patents, published patent
applications, Tables, Appendices, and the sequence listing cited
throughout this application are hereby incorporated by
reference.
EXEMPLIFICATION
Example 1
Preparation of Total Genomic DNA of Corynebacterium glutamicum ATCC
13032
[0126] A culture of Corynebacterium glutamicum (ATCC 13032) was
grown overnight at 30.degree. C. with vigorous shaking in BHI
medium (Difco). The cells were harvested by centrifugation, the
supernatant was discarded and the cells were resuspended in 5 ml
buffer-I (5% of the original volume of the culture--all indicated
volumes have been calculated for 100 ml of culture volume).
Composition of buffer-I: 140.34 g/l sucrose, 2.46 g/l
MgSO.sub.4.times.7H.sub.2O, 10 ml/l KH.sub.2PO.sub.4 solution (100
g/l, adjusted to pH 6.7 with KOH), 50 ml/l M12 concentrate (10 g/l
(NH.sub.4).sub.2SO.sub.4, 1 g/l NaCl, 2 g/l
MgSO.sub.4.times.7H.sub.2O, 0.2 g/l CaCl.sub.2, 0.5 g/l yeast
extract (Difco), 10 ml/l trace-elements-mix (200 mg/l
FeSO.sub.4.times.H.sub.2O, 10 mg/l ZnSO.sub.4.times.7H.sub.2O, 3
mg/l MnCl.sub.2.times.4H.sub.2O, 30 mg/l H.sub.3BO.sub.3 20 mg/l
CoCl.sub.2.times.6H.sub.2O, 1 mg/l NiCl.sub.2.times.6H.sub.2O, 3
mg/l Na.sub.2MoO.sub.4.times.2H.sub.2O, 500 mg/l complexing agent
(EDTA or critic acid), 100 ml/l vitamins-mix (0.2 mg/l biotin, 0.2
mg/l folic acid, 20 mg/l p-amino benzoic acid, 20 mg/l riboflavin,
40 mg/l ca-panthothenate, 140 mg/l nicotinic acid, 40 mg/l
pyridoxole hydrochloride, 200 mg/l myo-inositol). Lysozyme was
added to the suspension to a final concentration of 2.5 mg/ml.
After an approximately 4 h incubation at 37.degree. C., the cell
wall was degraded and the resulting protoplasts are harvested by
centrifugation. The pellet was washed once with 5 ml buffer-I and
once with 5 ml TE-buffer (10 mM Tris-HCl, 1 mM EDTA, pH 8). The
pellet was resuspended in 4 ml TE-buffer and 0.5 ml SDS solution
(10%) and 0.5 ml NaCl solution (5 M) are added. After adding of
proteinase K to a final concentration of 200 .mu.g/ml, the
suspension is incubated for ca. 18 h at 37.degree. C. The DNA was
purified by extraction with phenol,
phenol-chloroform-isoamylalcohol and chloroform-isoamylalcohol
using standard procedures. Then, the DNA was precipitated by adding
1/50 volume of 3 M sodium acetate and 2 volumes of ethanol,
followed by a 30 min incubation at -20.degree. C. and a 30 min
centrifugation at 12,000 rpm in a high speed centrifuge using a
SS34 rotor (Sorvall). The DNA was dissolved in 1 ml TE-buffer
containing 20 .mu.g/ml RNaseA and dialysed at 4.degree. C. against
1000 ml TE-buffer for at least 3 hours. During this time, the
buffer was exchanged 3 times. To aliquots of 0.4 ml of the dialysed
DNA solution, 0.4 ml of 2 M LiCl and 0.8 ml of ethanol are added.
After a 30 min incubation at -20.degree. C., the DNA was collected
by centrifugation (13,000 rpm, Biofuge Fresco, Heraeus, Hanau,
Germany). The DNA pellet was dissolved in TE-buffer. DNA prepared
by this procedure could be used for all purposes, including
southern blotting or construction of genomic libraries.
Example 2
Construction of Genomic Libraries in Escherichia coli of
Corynebacterium glutamicum ATCC13032
[0127] Using DNA prepared as described in Example 1, cosmid and
plasmid libraries were constructed according to known and well
established methods (see e.g., Sambrook, J. et al. (1989)
"Molecular Cloning: A Laboratory Manual", Cold Spring Harbor
Laboratory Press, or Ausubel, F. M. et al. (1994) "Current
Protocols in Molecular Biology", John Wiley & Sons.)
[0128] Any plasmid or cosmid could be used. Of particular use were
the plasmids pBR322 (Sutcliffe, J. G. (1979) Proc. Natl. Acad. Sci.
USA, 75:3737-3741); pACYC177 (Change & Cohen (1978) J.
Bacteriol 134:1141-1156), plasmids of the pBS series (pBSSK+,
pBSSK- and others; Stratagene, LaJolla, USA), or cosmids as
SuperCos1 (Stratagene, LaJolla, USA) or Lorist6 (Gibson, T. J.,
Rosenthal A. and Waterson, R. H. (1987) Gene 53:283-286. Gene
libraries specifically for use in C. glutamicum may be constructed
using plasmid pSL109 (Lee, H.-S. and A. J. Sinskey (1994) J.
Microbiol. Biotechnol. 4: 256-263).
Example 3
DNA Sequencing and Computational Functional Analysis
[0129] Genomic libraries as described in Example 2 were used for
DNA sequencing according to standard methods, in particular by the
chain termination method using ABI377 sequencing machines (see
e.g., Fleischman, R. D. et al. (1995) "Whole-genome Random
Sequencing and Assembly of Haemophilus Influenzae Rd., Science,
269:496-512). Sequencing primers with the following nucleotide
sequences were used: 5'-GGAAACAGTATGACCATG-3' or
5'-GTAAAACGACGGCCAGT-3'.
Example 4
In Vivo Mutagenesis
[0130] In vivo mutagenesis of Corynebacterium glutamicum can be
performed by passage of plasmid (or other vector) DNA through E.
coli or other microorganisms (e.g. Bacillus spp. or yeasts such as
Saccharomyces cerevisiae) which are impaired in their capabilities
to maintain the integrity of their genetic information. Typical
mutator strains have mutations in the genes for the DNA repair
system (e.g., mutHLS, mutD, mutT, etc.; for reference, see Rupp, W.
D. (1996) DNA repair mechanisms, in: Escherichia coli and
Salmonella, p. 2277-2294, ASM: Washington.) Such strains are well
known to those of ordinary skill in the art. The use of such
strains is illustrated, for example, in Greener, A. and Callahan,
M. (1994) Strategies 7: 32-34.
Example 5
DNA Transfer Between Escherichia Coli and Corynebacterium
glutamicum
[0131] Several Corynebacterium and Brevibacterium species contain
endogenous plasmids (as e.g., pHM1519 or pBL1) which replicate
autonomously (for review see, e.g., Martin, J. F. et al. (1987)
Biotechnology, 5:137-146). Shuttle vectors for Escherichia coli and
Corynebacterium glutamicum can be readily constructed by using
standard vectors for E. coli (Sambrook, J. et al. (1989),
"Molecular Cloning: A Laboratory Manual", Cold Spring Harbor
Laboratory Press or Ausubel, F. M. et al. (1994) "Current Protocols
in Molecular Biology", John Wiley & Sons) to which a origin or
replication for and a suitable marker from Corynebacterium
glutamicum is added. Such origins of replication are preferably
taken from endogenous plasmids isolated from Corynebacterium and
Brevibacterium species. Of particular use as transformation markers
for these species are genes for kanamycin resistance (such as those
derived from the Tn5 or Tn903 transposons) or chloramphenicol
(Winnacker, E. L. (1987) "From Genes to Clones--Introduction to
Gene Technology, VCH, Weinheim). There are numerous examples in the
literature of the construction of a wide variety of shuttle vectors
which replicate in both E. coli and C. glutamicum, and which can be
used for several purposes, including gene over-expression (for
reference, see e.g., Yoshihama, M. et al. (1985) J. Bacteriol.
162:591-597, Martin J. F. et al. (1987) Biotechnology, 5:137-146
and Eikmanns, B. J. et al. (1991) Gene, 102:93-98).
[0132] Using standard methods, it is possible to clone a gene of
interest into one of the shuttle vectors described above and to
introduce such a hybrid vectors into strains of Corynebacterium
glutamicum. Transformation of C. glutamicum can be achieved by
protoplast transformation (Kastsumata, R. et al. (1984) J.
Bacteriol. 159306-311), electroporation (Liebl, E. et al. (1989)
FEMS Microbiol. Letters, 53:399-303) and in cases where special
vectors are used, also by conjugation (as described e.g. in
Schafer, A et al. (1990) J. Bacteriol. 172:1663-1666). It is also
possible to transfer the shuttle vectors for C. glutamicum to E.
coli by preparing plasmid DNA from C. glutamicum (using standard
methods well-known in the art) and transforming it into E. coli.
This transformation step can be performed using standard methods,
but it is advantageous to use an Mcr-deficient E. coli strain, such
as NM522 (Gough & Murray (1983) J. Mol. Biol. 166:1-19).
[0133] Genes may be overexpressed in C. glutamicum strains using
plasmids which comprise pCG1 (U.S. Pat. No. 4,617,267) or fragments
thereof, and optionally the gene for kanamycin resistance from
TN903 (Grindley, N. D. and Joyce, C. M. (1980) Proc. Natl. Acad.
Sci. USA 77(12): 7176-7180). In addition, genes may be
overexpressed in C. glutamicum strains using plasmid pSL109 (Lee,
H.-S. and A. J. Sinskey (1994) J. Microbiol. Biotechnol. 4:
256-263).
[0134] Aside from the use of replicative plasmids, gene
overexpression can also be achieved by integration into the genome.
Genomic integration in C. glutamicum or other Corynebacterium or
Brevibacterium species may be accomplished by well-known methods,
such as homologous recombination with genomic region(s),
restriction endonuclease mediated integration (REMI) (see, e.g., DE
Patent 19823834), or through the use of transposons. It is also
possible to modulate the activity of a gene of interest by
modifying the regulatory regions (e.g., a promoter, a repressor,
and/or an enhancer) by sequence modification, insertion, or
deletion using site-directed methods (such as homologous
recombination) or methods based on random events (such as
transposon mutagenesis or REMI). Nucleic acid sequences which
function as transcriptional terminators may also be inserted 3' to
the coding region of one or more genes of the invention; such
terminators are well-known in the art and are described, for
example, in Winnacker, E. L. (1987) From Genes to
Clones--Introduction to Gene Technology. VCH: Weinheim.
Example 6
Assessment of the Expression of the Mutant Protein
[0135] Observations of the activity of a mutated protein in a
transformed host cell rely on the fact that the mutant protein is
expressed in a similar fashion and in a similar quantity to that of
the wild-type protein. A useful method to ascertain the level of
transcription of the mutant gene (an indicator of the amount of
mRNA available for translation to the gene product) is to perform a
Northern blot (for reference see, for example, Ausubel et al.
(1988) Current Protocols in Molecular Biology, Wiley: New York), in
which a primer designed to bind to the gene of interest is labeled
with a detectable tag (usually radioactive or chemiluminescent),
such that when the total RNA of a culture of the organism is
extracted, run on gel, transferred to a stable matrix and incubated
with this probe, the binding and quantity of binding of the probe
indicates the presence and also the quantity of mRNA for this gene.
This information is evidence of the degree of transcription of the
mutant gene. Total cellular RNA can be prepared from
Corynebacterium glutamicum by several methods, all well-known in
the art, such as that described in Bormann, E. R. et al. (1992)
Mol. Microbiol. 6: 317-326.
[0136] To assess the presence or relative quantity of protein
translated from this mRNA, standard techniques, such as a Western
blot, may be employed (see, for example, Ausubel et al. (1988)
Current Protocols in Molecular Biology, Wiley: New York). In this
process, total cellular proteins are extracted, separated by gel
electrophoresis, transferred to a matrix such as nitrocellulose,
and incubated with a probe, such as an antibody, which specifically
binds to the desired protein. This probe is generally tagged with a
chemiluminescent or colorimetric label which may be readily
detected. The presence and quantity of label observed indicates the
presence and quantity of the desired mutant protein present in the
cell.
Example 7
Growth of Genetically Modified Corynebacterium glutamicum --Media
and Culture Conditions
[0137] Genetically modified Corynebacteria are cultured in
synthetic or natural growth media. A number of different growth
media for Corynebacteria are both well-known and readily available
(Lieb et al. (1989) Appl. Microbiol. Biotechnol., 32:205-210; von
der Osten et al. (1998) Biotechnology Letters, 11:11-16; Patent DE
4,120,867; Liebl (1992) "The Genus Corynebacterium, in: The
Procaryotes, Volume II, Balows, A. et al., eds. Springer-Verlag).
These media consist of one or more carbon sources, nitrogen
sources, inorganic salts, vitamins and trace elements. Preferred
carbon sources are sugars, such as mono-, di-, or polysaccharides.
For example, glucose, fructose, mannose, galactose, ribose,
sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or
cellulose serve as very good carbon sources. It is also possible to
supply sugar to the media via complex compounds such as molasses or
other by-products from sugar refinement. It can also be
advantageous to supply mixtures of different carbon sources. Other
possible carbon sources are alcohols and organic acids, such as
methanol, ethanol, acetic acid or lactic acid. Nitrogen sources are
usually organic or inorganic nitrogen compounds, or materials which
contain these compounds. Exemplary nitrogen sources include ammonia
gas or ammonia salts, such as NH.sub.4Cl or
(NH.sub.4).sub.2SO.sub.4, NH.sub.4OH, nitrates, urea, amino acids
or complex nitrogen sources like corn steep liquor, soy bean flour,
soy bean protein, yeast extract, meat extract and others.
[0138] Inorganic salt compounds which may be included in the media
include the chloride-, phosphorous- or sulfate-salts of calcium,
magnesium, sodium, cobalt, molybdenum, potassium, manganese, zinc,
copper and iron. Chelating compounds can be added to the medium to
keep the metal ions in solution. Particularly useful chelating
compounds include dihydroxyphenols, like catechol or
protocatechuate, or organic acids, such as citric acid. It is
typical for the media to also contain other growth factors, such as
vitamins or growth promoters, examples of which include biotin,
riboflavin, thiamin, folic acid, nicotinic acid, pantothenate and
pyridoxin. Growth factors and salts frequently originate from
complex media components such as yeast extract, molasses, corn
steep liquor and others. The exact composition of the media
compounds depends strongly on the immediate experiment and is
individually decided for each specific case. Information about
media optimization is available in the textbook "Applied Microbiol.
Physiology, A Practical Approach (eds. P. M. Rhodes, P. F.
Stanbury, IRL Press (1997) pp. 53-73, ISBN 0 19 963577 3). It is
also possible to select growth media from commercial suppliers,
like standard 1 (Merck) or BHI (grain heart infusion, DIFCO) or
others.
[0139] All medium components are sterilized, either by heat (20
minutes at 1.5 bar and 121.degree. C.) or by sterile filtration.
The components can either be sterilized together or, if necessary,
separately. All media components can be present at the beginning of
growth, or they can optionally be added continuously or
batchwise.
[0140] Culture conditions are defined separately for each
experiment. The temperature should be in a range between 15.degree.
C. and 45.degree. C. The temperature can be kept constant or can be
altered during the experiment. The pH of the medium should be in
the range of 5 to 8.5, preferably around 7.0, and can be maintained
by the addition of buffers to the media. An exemplary buffer for
this purpose is a potassium phosphate buffer. Synthetic buffers
such as MOPS, HEPES, ACES and others can alternatively or
simultaneously be used. It is also possible to maintain a constant
culture pH through the addition of NaOH or NH.sub.4OH during
growth. If complex medium components such as yeast extract are
utilized, the necessity for additional buffers may be reduced, due
to the fact that many complex compounds have high buffer
capacities. If a fermentor is utilized for culturing the
microorganisms, the pH can also be controlled using gaseous
ammonia.
[0141] The incubation time is usually in a range from several hours
to several days. This time is selected in order to permit the
maximal amount of product to accumulate in the broth. The disclosed
growth experiments can be carried out in a variety of vessels, such
as microtiter plates, glass tubes, glass flasks or glass or metal
fermentors of different sizes. For screening a large number of
clones, the microorganisms should be cultured in microtiter plates,
glass tubes or shake flasks, either with or without baffles.
Preferably 100 ml shake flasks are used, filled with 10% (by
volume) of the required growth medium. The flasks should be shaken
on a rotary shaker (amplitude 25 mm) using a speed-range of 100-300
rpm. Evaporation losses can be diminished by the maintenance of a
humid atmosphere; alternatively, a mathematical correction for
evaporation losses should be performed.
[0142] If genetically modified clones are tested, an unmodified
control clone or a control clone containing the basic plasmid
without any insert should also be tested. The medium is inoculated
to an OD.sub.600 of 0.5-1.5 using cells grown on agar plates, such
as CM-plates (10 g/l glucose, 2,5 g/l NaCl, 2 g/l urea, 10 g/l
polypeptone, 5 g/l yeast extract, 5 g/l meat extract, 22 g/l NaCl,
2 g/l urea, 10 g/l polypeptone, 5 g/l yeast extract, 5 g/l meat
extract, 22 g/l agar, pH 6.8 with 2M NaOH) that had been incubated
at 30.degree. C. Inoculation of the media is accomplished by either
introduction of a saline suspension of C. glutamicum cells from CM
plates or addition of a liquid preculture of this bacterium.
Example 8
In vitro Analysis of the Function of Mutant Proteins
[0143] The determination of activities and kinetic parameters of
enzymes is well established in the art. Experiments to determine
the activity of any given altered enzyme must be tailored to the
specific activity of the wild-type enzyme, which is well within the
ability of one of ordinary skill in the art. Overviews about
enzymes in general, as well as specific details concerning
structure, kinetics, principles, methods, applications and examples
for the determination of many enzyme activities may be found, for
example, in the following references: Dixon, M., and Webb, E. C.,
(1979) Enzymes. Longmans: London; Fersht, (1985) Enzyme Structure
and Mechanism. Freeman: New York; Walsh, (1979) Enzymatic Reaction
Mechanisms. Freeman: San Francisco; Price, N.C., Stevens, L. (1982)
Fundamentals of Enzymology. Oxford Univ. Press: Oxford; Boyer, P.
D., ed. (1983) The Enzymes, 3.sup.rd ed. Academic Press: New York;
Bisswanger, H., (1994) Enzymkinetik, 2.sup.nd ed. VCH: Weinheim
(ISBN 3527300325); Bergmeyer, H. U., Bergmeyer, J., Gra.beta.l, M.,
eds. (1983-1986) Methods of Enzymatic Analysis, 3.sup.rd ed., vol.
I-XII, Verlag Chemie: Weinheim; and Ullmann's Encyclopedia of
Industrial Chemistry (1987) vol. A9, "Enzymes". VCH: Weinheim, p.
352-363.
[0144] The activity of proteins which bind to DNA can be measured
by several well-established methods, such as DNA band-shift assays
(also called gel retardation assays). The effect of such proteins
on the expression of other molecules can be measured using reporter
gene assays (such as that described in Kolmar, H. et al. (1995)
EMBO J. 14: 3895-3904 and references cited therein). Reporter gene
test systems are well known and established for applications in
both pro- and eukaryotic cells, using enzymes such as
beta-galactosidase, green fluorescent protein, and several
others.
[0145] The determination of activity of membrane-transport proteins
can be performed according to techniques such as those described in
Gennis, R. B. (1989) "Pores, Channels and Transporters", in
Biomembranes, Molecular Structure and Function, Springer:
Heidelberg, p. 85-137; 199-234; and 270-322.
Example 9
Analysis of Impact of Mutant Protein on the Production of the
Desired Product
[0146] The effect of the genetic modification in C. glutamicum on
production of a desired compound (such as an amino acid) can be
assessed by growing the modified microorganism under suitable
conditions (such as those described above) and analyzing the medium
and/or the cellular component for increased production of the
desired product (i.e., an amino acid). Such analysis techniques are
well known to one of ordinary skill in the art, and include
spectroscopy, thin layer chromatography, staining methods of
various kinds, enzymatic and microbiological methods, and
analytical chromatography such as high performance liquid
chromatography (see, for example, Ullman, Encyclopedia of
Industrial Chemistry, vol. A2, p. 89-90 and p. 443-613, VCH:
Weinheim (1985); Fallon, A. et al., (1987) "Applications of HPLC in
Biochemistry" in: Laboratory Techniques in Biochemistry and
Molecular Biology, vol. 17; Rehm et al. (1993) Biotechnology, vol.
3, Chapter III: "Product recovery and purification", page 469-714,
VCH: Weinheim; Belter, P. A. et al. (1988) Bioseparations:
downstream processing for biotechnology, John Wiley and Sons;
Kennedy, J. F. and Cabral, J. M. S. (1992) Recovery processes for
biological materials, John Wiley and Sons; Shaeiwitz, J. A. and
Henry, J. D. (1988) Biochemical separations, in: Ulmann's
Encyclopedia of Industrial Chemistry, vol. B3, Chapter 11, page
1-27, VCH: Weinheim; and Dechow, F. J. (1989) Separation and
purification techniques in biotechnology, Noyes Publications.)
[0147] In addition to the measurement of the final product of
fermentation, it is also possible to analyze other components of
the metabolic pathways utilized for the production of the desired
compound, such as intermediates and side-products, to determine the
overall efficiency of production of the compound. Analysis methods
include measurements of nutrient levels in the medium (e.g.,
sugars, hydrocarbons, nitrogen sources, phosphate, and other ions),
measurements of biomass composition and growth, analysis of the
production of common metabolites of biosynthetic pathways, and
measurement of gasses produced during fermentation. Standard
methods for these measurements are outlined in Applied Microbial
Physiology, A Practical Approach, P. M. Rhodes and P. F. Stanbury,
eds., IRL Press, p. 103-129; 131-163; and 165-192 (ISBN:
0199635773) and references cited therein.
Example 10
Purification of the Desired Product from C. glutamicum Culture
[0148] Recovery of the desired product from the C. glutamicum cells
or supernatant of the above-described culture can be performed by
various methods well known in the art. If the desired product is
not secreted from the cells, the cells can be harvested from the
culture by low-speed centrifugation, the cells can be lysed by
standard techniques, such as mechanical force or sonication. The
cellular debris is removed by centrifugation, and the supernatant
fraction containing the soluble proteins is retained for further
purification of the desired compound. If the product is secreted
from the C. glutamicum cells, then the cells are removed from the
culture by low-speed centrifugation, and the supernate fraction is
retained for further purification.
[0149] The supernatant fraction from either purification method is
subjected to chromatography with a suitable resin, in which the
desired molecule is either retained on a chromatography resin while
many of the impurities in the sample are not, or where the
impurities are retained by the resin while the sample is not. Such
chromatography steps may be repeated as necessary, using the same
or different chromatography resins. One of ordinary skill in the
art would be well-versed in the selection of appropriate
chromatography resins and in their most efficacious application for
a particular molecule to be purified. The purified product may be
concentrated by filtration or ultrafiltration, and stored at a
temperature at which the stability of the product is maximized.
[0150] There are a wide array of purification methods known to the
art and the preceding method of purification is not meant to be
limiting. Such purification techniques are described, for example,
in Bailey, J. E. & Ollis, D. F. Biochemical Engineering
Fundamentals, McGraw-Hill: New York (1986).
[0151] The identity and purity of the isolated compounds may be
assessed by techniques standard in the art. These include
high-performance liquid chromatography (HPLC), spectroscopic
methods, staining methods, thin layer chromatography, NIRS,
enzymatic assay, or microbiologically. Such analysis methods are
reviewed in: Patek et al. (1994) Appl. Environ. Microbiol. 60:
133-140; Malakhova et al. (1996) Biotekhnologiya 11: 27-32; and
Schmidt et al. (1998) Bioprocess Engineer. 19: 67-70. Ulmann's
Encyclopedia of Industrial Chemistry, (1996) vol. A27, VCH:
Weinheim, p. 89-90, p. 521-540, p. 540-547, p. 559-566, 575-581 and
p. 581-587; Michal, G. (1999) Biochemical Pathways: An Atlas of
Biochemistry and Molecular Biology, John Wiley and Sons; Fallon, A.
et al. (1987) Applications of HPLC in Biochemistry in: Laboratory
Techniques in Biochemistry and Molecular Biology, vol. 17.
Example 11
Analysis of the Gene Sequences of the Invention
[0152] The comparison of sequences and determination of percent
homology between two sequences are art-known techniques, and can be
accomplished using a mathematical algorithm, such as the algorithm
of Karlin and Altschul (1990) Proc. Natl. Acad Sci. USA 87:2264-68,
modified as in Karlin and Altschul (1993) Proc. Natl. Acad. Sci.
USA 90:5873-77. Such an algorithm is incorporated into the NBLAST
and XBLAST programs (version 2.0) of Altschul, et al. (1990) J.
Mol. Biol. 215:403-10. BLAST nucleotide searches can be performed
with the NBLAST program, score=100, wordlength=12 to obtain
nucleotide sequences homologous to MCP nucleic acid molecules of
the invention. BLAST protein searches can be performed with the
XBLAST program, score=50, wordlength=3 to obtain amino acid
sequences homologous to MCP protein molecules of the invention. To
obtain gapped alignments for comparison purposes, Gapped BLAST can
be utilized as described in Altschul et al., (1997) Nucleic Acids
Res. 25(17):3389-3402. When utilizing BLAST and Gapped BLAST
programs, one of ordinary skill in the art will know how to
optimize the parameters of the program (e.g., XBLAST and NBLAST)
for the specific sequence being analyzed.
[0153] Another example of a mathematical algorithm utilized for the
comparison of sequences is the algorithm of Meyers and Miller
((1988) Comput. Appl. Biosci. 4: 11-17). Such an algorithm is
incorporated into the ALIGN program (version 2.0) which is part of
the GCG sequence alignment software package. When utilizing the
ALIGN program for comparing amino acid sequences, a PAM120 weight
residue table, a gap length penalty of 12, and a gap penalty of 4
can be used. Additional algorithms for sequence analysis are known
in the art, and include ADVANCE and ADAM. described in Torelli and
Robotti (1994) Comput. Appl. Biosci. 10:3-5; and FASTA, described
in Pearson and Lipman (1988) P.N.A.S. 85:2444-8.
[0154] The percent homology between two amino acid sequences can
also be accomplished using the GAP program in the GCG software
package (available at http://www.gcg.com), using either a Blosum 62
matrix or a PAM250 matrix, and a gap weight of 12, 10, 8, 6, or 4
and a length weight of 2, 3, or 4. The percent homology between two
nucleic acid sequences can be accomplished using the GAP program in
the GCG software package, using standard parameters, such as a gap
weight of 50 and a length weight of 3.
[0155] A comparative analysis of the gene sequences of the
invention with those present in Genbank has been performed using
techniques known in the art (see, e.g., Bexevanis and Ouellette,
eds. (1998) Bioinformatics: A Practical Guide to the Analysis of
Genes and Proteins. John Wiley and Sons: New York). The gene
sequences of the invention were compared to genes present in
Genbank in a three-step process. In a first step, a BLASTN analysis
(e.g., a local alignment analysis) was performed for each of the
sequences of the invention against the nucleotide sequences present
in Genbank, and the top 500 hits were retained for further
analysis. A subsequent FASTA search (e.g., a combined local and
global alignment analysis, in which limited regions of the
sequences are aligned) was performed on these 500 hits. Each gene
sequence of the invention was subsequently globally aligned to each
of the top three FASTA hits, using the GAP program in the GCG
software package (using standard parameters). In order to obtain
correct results, the length of the sequences extracted from Genbank
were adjusted to the length of the query sequences by methods
well-known in the art. The results of this analysis are set forth
in Table 4. The resulting data is identical to that which would
have been obtained had a GAP (global) analysis alone been performed
on each of the genes of the invention in comparison with each of
the references in Genbank, but required significantly reduced
computational time as compared to such a database-wide GAP (global)
analysis. Sequences of the invention for which no alignments above
the cutoff values were obtained are indicated on Table 4 by the
absence of alignment information. It will further be understood by
one of ordinary skill in the art that the GAP alignment homology
percentages set forth in Table 4 under the heading "% homology
(GAP)" are listed in the European numerical format, wherein a `,`
represents a decimal point. For example, a value of "40,345" in
this column represents "40.345%".
Example 12
Construction and Operation of DNA Microarrays
[0156] The sequences of the invention may additionally be used in
the construction and application of DNA microarrays (the design,
methodology, and uses of DNA arrays are well known in the art, and
are described, for example, in Schena, M. et al. (1995) Science
270: 467-470; Wodicka, L. et al. (1997) Nature Biotechnology 15:
1359-1367; DeSaizieu, A. et al. (1998) Nature Biotechnology 16:
45-48; and DeRisi, J. L. et al. (1997) Science 278: 680-686).
[0157] DNA microarrays are solid or flexible supports consisting of
nitrocellulose, nylon, glass, silicone, or other materials. Nucleic
acid molecules may be attached to the surface in an ordered manner.
After appropriate labeling, other nucleic acids or nucleic acid
mixtures can be hybridized to the immobilized nucleic acid
molecules, and the label may be used to monitor and measure the
individual signal intensities of the hybridized molecules at
defined regions. This methodology allows the simultaneous
quantification of the relative or absolute amount of all or
selected nucleic acids in the applied nucleic acid sample or
mixture. DNA microarrays, therefore, permit an analysis of the
expression of multiple (as many as 6800 or more) nucleic acids in
parallel (see, e.g., Schena, M. (1996) BioEssays 18(5):
427-431).
[0158] The sequences of the invention may be used to design
oligonucleotide primers which are able to amplify defined regions
of one or more C. glutamicum genes by a nucleic acid amplification
reaction such as the polymerase chain reaction. The choice and
design of the 5' or 3' oligonucleotide primers or of appropriate
linkers allows the covalent attachment of the resulting PCR
products to the surface of a support medium described above (and
also described, for example, Schena, M. et al. (1995) Science 270:
467-470).
[0159] Nucleic acid microarrays may also be constructed by in situ
oligonucleotide, synthesis as described by Wodicka, L. et al.
(1997) Nature Biotechnology 15: 1359-1367. By photolithographic
methods, precisely defined regions of the matrix are exposed to
light. Protective groups which are photolabile are thereby
activated and undergo nucleotide addition, whereas regions that are
masked from light do not undergo any modification. Subsequent
cycles of protection and light activation permit the synthesis of
different oligonucleotides at defined positions. Small, defined
regions of the genes of the invention may be synthesized on
microarrays by solid phase oligonucleotide synthesis.
[0160] The nucleic acid molecules of the invention present in a
sample or mixture of nucleotides may be hybridized to the
microarrays. These nucleic acid molecules can be labeled according
to standard methods. In brief, nucleic acid molecules (e.g., mRNA
molecules or DNA molecules) are labeled by the incorporation of
isotopically or fluorescently labeled nucleotides, e.g., during
reverse transcription or DNA synthesis. Hybridization of labeled
nucleic acids to microarrays is described (e.g., in Schena, M. et
al. (1995) supra; Wodicka, L. et al. (1997), supra; and DeSaizieu
A. et al. (1998), supra). The detection and quantification of the
hybridized molecule are tailored to the specific incorporated
label. Radioactive labels can be detected, for example, as
described in Schena, M. et al. (1995) supra) and fluorescent labels
may be detected, for example, by the method of Shalon et al. (1996)
Genome Research 6: 639-645).
[0161] The application of the sequences of the invention to DNA
microarray technology, as described above, permits comparative
analyses of different strains of C. glutamicum or other
Corynebacteria. For example, studies of inter-strain variations
based on individual transcript profiles and the identification of
genes that are important for specific and/or desired strain
properties such as pathogenicity, productivity and stress tolerance
are facilitated by nucleic acid array methodologies. Also,
comparisons of the profile of expression of genes of the invention
during the course of a fermentation reaction are possible using
nucleic acid array technology.
Example 13
Analysis of the Dynamics of Cellular Protein Populations
(Proteomics)
[0162] The genes, compositions, and methods of the invention may be
applied to study the interactions and dynamics of populations of
proteins, termed `proteomics`. Protein populations of interest
include, but are not limited to, the total protein population of C.
glutamicum (e.g., in comparison with the protein populations of
other organisms), those proteins which are active under specific
environmental or metabolic conditions (e.g., during fermentation,
at high or low temperature, or at high or low pH), or those
proteins which are active during specific phases of growth and
development.
[0163] Protein populations can be analyzed by various well-known
techniques, such as gel electrophoresis. Cellular proteins may be
obtained, for example, by lysis or extraction, and may be separated
from one another using a variety of electrophoretic techniques.
Sodium dodecyl sulfate polyacrylamide gel electrophoresis
(SDS-PAGE) separates proteins largely on the basis of their
molecular weight. Isoelectric focusing polyacrylamide gel
electrophoresis (IEF-PAGE) separates proteins by their isoelectric
point (which reflects not only the amino acid sequence but also
posttranslational modifications of the protein). Another, more
preferred method of protein analysis is the consecutive combination
of both IEF-PAGE and SDS-PAGE, known as 2-D-gel electrophoresis
(described, for example, in Hermann et al. (1998) Electrophoresis
19: 3217-3221; Fountoulakis et al. (1998) Electrophoresis 19:
1193-1202; Langen et al. (1997) Electrophoresis 18: 1184-1192;
Antelmann et al. (1997) Electrophoresis 18: 1451-1463). Other
separation techniques may also be utilized for protein separation,
such as capillary gel electrophoresis; such techniques are well
known in the art.
[0164] Proteins separated by these methodologies can be visualized
by standard techniques, such as by staining or labeling. Suitable
stains are known in the art, and include Coomassie Brilliant Blue,
silver stain, or fluorescent dyes such as Sypro Ruby (Molecular
Probes). The inclusion of radioactively labeled amino acids or
other protein precursors (e.g., .sup.35S-methionine,
.sup.35S-cysteine, .sup.14C-labelled amino acids, .sup.15N-amino
acids, .sup.15NO.sub.3 or .sup.15NH.sub.4+ or .sup.13C-labelled
amino acids) in the medium of C. glutamicum permits the labeling of
proteins from these cells prior to their separation. Similarly,
fluorescent labels may be employed. These labeled proteins can be
extracted, isolated and separated according to the previously
described techniques.
[0165] Proteins visualized by these techniques can be further
analyzed by measuring the amount of dye or label used. The amount
of a given protein can be determined quantitatively using, for
example, optical methods and can be compared to the amount of other
proteins in the same gel or in other gels. Comparisons of proteins
on gels can be made, for example, by optical comparison, by
spectroscopy, by image scanning and analysis of gels, or through
the use of photographic films and screens. Such techniques are
well-known in the art.
[0166] To determine the identity of any given protein, direct
sequencing or other standard techniques may be employed. For
example, N- and/or C-terminal amino acid sequencing (such as Edman
degradation) may be used, as may mass spectrometry (in particular
MALDI or ESI techniques (see, e.g., Langen et al. (1997)
Electrophoresis 18: 1184-1192)). The protein sequences provided
herein can be used for the identification of C. glutamicum proteins
by these techniques.
[0167] The information obtained by these methods can be used to
compare patterns of protein presence, activity, or modification
between different samples from various biological conditions (e.g.,
different organisms, time points of fermentation, media conditions,
or different biotopes, among others). Data obtained from such
experiments alone, or in combination with other techniques, can be
used for various applications, such as to compare the behavior of
various organisms in a given (e.g., metabolic) situation, to
increase the productivity of strains which produce fine chemicals
or to increase the efficiency of the production of fine
chemicals.
Equivalents
[0168] Those of ordinary skill in the art will recognize, or will
be able to ascertain using no more than routine experimentation,
many equivalents to the specific embodiments of the invention
described herein. Such equivalents are intended to be encompassed
by the following claims. TABLE-US-00001 TABLE 4 ALIGNMENT RESULTS %
homo- length logy ID # (NT) Genbank Hit Length Accession Name of
Genbank Hit Source of Genbank Hit (GAP) Date of Deposit rxa00003
864 GB_BA2: MPAE000013 10328 AE000013 Mycoplasma pneumoniae section
13 of 63 of the complete genome. Mycoplasma pneumoniae 37,409
18-Nov-98 GB_BA2: MPAE000013 10328 AE000013 Mycoplasma pneumoniae
section 13 of 63 of the complete genome. Mycoplasma pneumoniae
36,768 18-Nov-98 rxa00008 615 GB_HTG2: AC007356 185382 AC007356
Drosophila melanogaster chromosome 2 clone BACR24H09 (D595)
Drosophila melanogaster 39,203 2-Aug-99 RPCI-98 24.H.9 map 49A-49B
strain y: cn bw sp. *** SEQUENCING IN PROGRESS ***, 13 unordered
pieces. GB_HTG2: AC007356 185382 AC007356 Drosophila melanogaster
chromosome 2 clone BACR24H09 (D595) Drosophila melanogaster 39,203
2-Aug-99 RPCI-98 24.H.9 map 49A-49B strain y; cn bw sp. ***
SEQUENCING IN PROGRESS***, 13 unordered pieces. GB_EST36: AV194293
380 AV194293 AV194293 Yuji Kohara unpublished cDNA: Strain N2
hermaphrodite embryo Caenorhabditis elegans 38,947 22-Jul-99
Caenorhabditis elegans cDNA clone yk627f12 5', mRNA sequence.
rxa00015 432 GB_GSS4: AQ684785 671 AQ684785 HS_5481_B2_H06_SP6E
RPCI-11 Human Male BAC Library Homo sapiens 41,388 28-Jun-99 Homo
sapiens genomic clone Plate = 1057 Col = 12 Row = P. genomic survey
sequence. GB_PR2: HS217O16 87552 AL031771 Human DNA sequence from
clone 217O16 on chromosome 6q24 Homo sapiens 37,471 23-Nov-99
Contains GSS, complete sequence. GB_EST15: AA528550 335 AA528550
nf01f01.s1 NCI_CGAP_Kid1 Homo sapiens cDNA clone Homo sapiens
40,789 19-Aug-97 IMAGE: 912505, mRNA sequence. rxa00018 1422 GB_VI:
HS5MCP 4320 M25411 Human cytomegalovirus major capsid protein (MCP)
gene, complete cds. human herpesvirus 5 38,231 30-OCT-1994 GB_BA2:
AE001270 12448 AE001270 Treponema pallidum section 86 of 87 of the
complete genome. Treponema pallidum 37,13 16-Jul-98 GB_IN1:
LMFL2385 22004 AL034389 Leishmania major Friedlin cosmid L2385,
complete sequence. Leishmania major 37,518 15-MAR-1999 rxa00020 903
GB_PR4: AC006960 179757 AC006960 Homo sapiens clone UWGC: djs58
from 7p14-15, complete sequence. Homo sapiens 36,618 05-MAR-1999
GB_HTG3: AC008266 178972 AC008266 Homo sapiens clone DJ1145A24, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 35,419 21-Aug-99 3
unordered pieces. GB_HTG3: AC008266 178972 AC008266 Homo sapiens
clone DJ1145A24, *** SEQUENCING IN PROGRESS ***, Homo sapiens
35,419 21-Aug-99 3 unordered pieces. rxa00021 1896 GB_EST15:
AA496164 429 AA496164 zu67e09.r1 Soares_testis_NHT Homo sapiens
cDNA Homo sapiens 35,526 11-Aug-97 clone IMAGE: 743080 5', mRNA
sequence. GB_EST30: AI660039 443 AI660039 we65d06.x1
Soares_thymus_NHFTh Homo sapiens Homo sapiens 42,574 10-MAY-1999
cDNA clone IMAGE: 2345963 3', mRNA sequence. GB_EST37: AI953059 522
AI953059 wq49g08.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone Homo
sapiens 39,198 6-Sep-99 IMAGE: 2474650 3', mRNA sequence. rxa00022
1824 GB_EST15: AA496164 429 AA496164 zu67e09.r1 Soares_testis_NHT
Homo sapiens cDNA clone Homo sapiens 41,141 11-Aug-97 IMAGE: 743080
5', mRNA sequence. GB_PR3: AF022141 43473 AF022141 Homo sapiens
chromosome 21q22.2 cosmid Q13F10. complete sequence. Homo sapiens
37,262 21-Jan-98 GB_EST18: AA678649 538 AA678649 ah07c05.s1 Gessler
Witms tumor Homo sapiens cDNA clone Homo sapiens 38,104 02-DEC-1997
IMAGE: 1155944 3' similar to gb: X16869 ELONGATION FACTOR 1-ALPHA 1
(HUMAN);, mRNA sequence. rxa00025 1560 GB_PL2: AC009978 97554
AC009978 Genomic sequence for Arabidopsis thaliana BAC T23E18 from
Arabidopsis thaliana 34,173 15-Nov-99 chromosome I, complete
sequence. GB_HTG2: AC005958 216706 AC005958 Homo sapiens, ***
SEQUENCING IN PROGRESS ***, 40 unordered pieces. Homo sapiens
35,374 11-Nov-98 GB_HTG2: AC005958 216706 AC005958 Homo sapiens,
*** SEQUENCING IN PROGRESS ***, 40 unordered pieces. Homo sapiens
35,374 11-Nov-98 rxa00027 489 GB_PR3: HSDJ247C2 98358 AL049713
Human DNA sequence from clone 247C2 on chromosome 11p13, complete
sequence. Homo sapiens 33,056 23-Nov-99 GB_PR3: HSDJ247C2 98358
AL049713 Human DNA sequence from clone 247C2 on chromosome 11p13,
complete sequence. Homo sapiens 37,988 23-Nov-99 rxa00028 rxa00031
525 GB_PL1: SPBC725 37949 AL034352 S. pombe chromosome II cosmid
c725. Schizosaccharomyces 36,084 29-MAR-1999 pombe GB_EST5: N22565
435 N22565 yw30f05.s1 Morton Fetal Cochlea Homo sapiens cDNA clone
IMAGE: Homo sapiens 41,57 20-DEC-1995 253761 3', mRNA sequence.
GB_EST21: AA993042 464 AA993042 ot92f07.s1
Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone IMAGE: Homo
sapiens 41,499 27-Aug-98 1624261 3', mRNA sequence. rxa00049 810
GB_HTG2: HSJ749H19 253387 AL117380 Homo sapiens chromosome 20 clone
RP4-749H19 map q13.11-13.33, Homo sapiens 37,132 03-DEC-1999 ***
SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: HSJ749H19
253387 AL117380 Homo sapiens chromosome 20 clone RP4-749H19 map
q13.11-13.33, Homo sapiens 37,132 03-DEC-1999 *** SEQUENCING IN
PROGRESS ***, in unordered pieces. GB_HTG4: AC010137 155817
AC010137 Homo sapiens clone NH0169D01, *** SEQUENCING Homo sapiens
40,052 17-OCT-1999 IN PROGRESS ***, 4 unordered pieces. rxa00052
834 GB_EST37: AI962012 382 AI962012 wt41e06.x1 NCI_CGAP_Pan1 Homo
sapiens cDNA clone IMAGE: Homo sapiens 40,486 20-Aug-99 2510050 3'
similar to SW: ALC2_HUMAN P01877 IG ALPHA-2 CHAIN C REGION.;, mRNA
sequence. GB_GSS13: AQ454792 450 AQ454792 HS_5195_B2_H04_SP6E
RPCI-11 Human Male BAC Library Homo sapiens 40,991 21-Apr-99 Homo
sapiens genomic clone Plate = 771 Col = 8 Row = P, genomic survey
sequence. GB_GSS13: AQ454792 450 AQ454792 HS_5195_B2_H04_SP6E
RPCI-11 Human Male BAC Library Homo sapiens 40,278 21-Apr-99 Homo
sapiens genomic clone Plate = 771 Col = 8 Row = P, genomic survey
sequence. rxa00054 3036 GB_GSS5: AQ773786 459 AQ773786
HS_2222_A1_E07_MR CIT Approved Human Genomic Sperm Library D Homo
sapiens 40,087 29-Jul-99 Homo sapiens genomic clone Plate = 2222
Col = 13 Row = 1, genomic survey sequence. GB_GSS5: AQ773786 459
AQ773786 HS_2222_A1_E07_MR CIT Approved Human Genomic Sperm Library
D Homo sapiens 40,087 29-Jul-99 Homo sapiens genomic clone Plate =
2222 Col = 13 Row = 1, genomic survey sequence. rxa00056 873
GB_IN1: CEF56H9 28291 Z74473 Caenorhabditis elegans cosmid F56H9,
complete sequence. Caenorhabditis elegans 35,301 23-Nov-98 GB_IN1:
CEF56H9 28291 Z74473 Caenorhabditis elegans cosmid F56H9, complele
sequence. Caenorhabditis elegans 38,941 23-Nov-98 rxa00058 687
GB_HTG6: AC011647 141830 AC011647 Homo sapiens clone RP11-15D18,
*** SEQUENCING IN PROGRESS ***, Homo sapiens 39,939 04-DEC-1999 29
unordered pieces. GB_HTG6: AC011647 141830 AC011647 Homo sapiens
clone RP11-15D18, *** SEQUENCING IN Homo sapiens 37,537 04-DEC-1999
PROGRESS ***, 29 unordered pieces. rxa00059 405 GB_GSS6: AQ825754
463 AQ825754 HS_5441_A2_G02_SP6E RPCI-11 Human Male BAC Library
Homo sapiens 34,444 27-Aug-99 Homo sapiens genomic clone Plate =
1017 Col = 4 Row = M, genomic survey sequence. GB_PAT: I32939 30001
I32939 Sequence 1 from patent U.S. Pat. No. 5589385. Unknown.
42,049 6-Feb-97 GB_PAT: AR031772 30001 AR031772 Sequence 1 from
patent U.S. Pat. No. 5866410. Unknown. 42,049 29-Sep-99 rxa00065
396 GB_PAT: E16763 2517 E16763 gDNA encoding aspartate transferase
(AAT). Corynebacterium 98,765 28-Jul-99 glutamicum GB_EST32:
AU050556 813 AU050556 AU050556 Paralichthys olivaceus library (Aoki
T) Paralichthys olivaceus Paralichthys olivaceus 35,638 8-Jun-99
cDNA clone WF7-19, mRNA sequence. GB_EST32: AU050215 733 AU050215
AU050215 Paralichthys olivaceus library (Aoki T) Paralichthys
olivaceus Paralichthys olivaceus 35,638 8-Jun-99 cDNA clone WB1-12,
mRNA sequence. rxa00067 609 GB_HTG3: AC008289 115120 AC008289
Drosophila melanogaster chromosome 2 clone BACR04E05 (D1055)
Drosophila melanogaster 30,397 17-Aug-99 RPCI-98 04.E.5 map 57B-57B
strain y; cn bw sp. *** SEQUENCING IN PROGRESS ***, 100 unordered
pieces. GB_IN2: AC004433 85862 AC004433 Drosophila melanogaster,
chromosome 2R, region 57B1-57B6, Drosophila melanogaster 35,501
01-DEC-1998 P1 clone DS03659, complete sequence. GB_HTG3: AC008289
115120 AC008289 Drosophila melanogaster chromosome 2 clone
BACR04E05 (D1055) Drosophila melanogaster 30,397 17-Aug-99 RPCI-98
04.E.5 map 57B-57B strain y; cn bw sp *** SEQUENCING IN PROGRESS
***, 100 unordered pieces. rxa00068 705 GB_PL2: ATAC006201 87947
AC006201 Arabidopsis thaliana chromosome I| BAC T27K22 genomic
Arabidopsis thaliana 39,099 12-MAR-1999 sequence, complete
sequence. GB_HTG5: AC010146 271437 AC010146 Homo sapiens clone
NH0355|13, WORKING DRAFT Homo sapiens 34,237 12-Nov-99 SEQUENCE, 1
unordered pieces. GB_GSS3: B85079 307 B85079 RPCI11-29O9.TP RPCI-11
Homo sapiens genomic clone Homo sapiens 39,56 9-Apr-99
RPCI-11-29O9, genomic survey sequence. rxa00077 1485 GB_PR4:
AC007157 152937 AC007157 Homo sapiens, clone hRPK.78_A_1, complete
sequence. Homo sapiens 37,661 27-Apr-99 GB_HTG1: CEY43C5 149571
AL021449 Caenorhabditis elegans chromosome IV clone Y43C5, ***
SEQUENCING IN Caenorhabditis elegans 25,242 23-Jan-98 PROGRESS ***,
in unordered pieces. GB_HTG1: CEY43C5 149571 AL021449
Caenorhabditis elegans chromosome IV clone Y43C5, *** SEQUENCING IN
Caenorhabditis elegans 38,258 23-Jan-98 PROGRESS ***, in unordered
pieces. rxa00079 345 GB_IN1: CTAJ2763 1097 AJ002763 Chironomus
tentans mRNA for P23 protein (23 kDa). Chironomus tentans 36,176
26-Jan-98 GB_IN1: CTHRP23 752 AJ003820 Chironomus tentans mRNA for
hnRNP protein, hrp23. Chironomus tentans 36,176 02-DEC-1998
GB_EST17: AA650674 540 AA650674 30788 Lambda-PRL2 Arabidopsis
thaliana cDNA clone 277G7T7, mRNA sequence. Arabidopsis thaliana
36,965 31-OCT-1997 rxa00080 1653 GB_EST38: AW039986 564 AW039986
EST282477 tomato mixed elicitor. BTI Lycopersicon esculentum cDNA
Lycopersicon esculentum 38,078 18-OCT-1999 clone cLET19F23, mRNA
sequence. GB_EST33: AI778332 378 AI778332 EST259211 tomato
susceptible, Cornell Lycopersicon esculentum cDNA Lycopersicon
esculentum 38,298 29-Jun-99 clone cLES5A13, mRNA sequence.
GB_EST38: AW039988 564 AW039988 EST282479 tomato mixed elicitor,
BTI Lycopersicon esculentum Lycopersicon esculentum 38,078
18-OCT-1999 cDNA clone cLET19F23, mRNA sequence. rxa00082 687
GB_PR1: HSS171 333303 AJ011930 Homo sapiens chromosome 21q22.3, PAC
clones 314N7, 225L15, Homo sapiens 36,111 10-Nov-98 BAC clone 7B7,
complete sequence bases 1..333303. GB_PR1: HSS171 333303 AJ011930
Homo sapiens chromosome 21q22.3, PAC clones 314N7, Homo sapiens
35,432 10-Nov-98 225L15, BAC clone 7B7, complete sequence bases
1..333303. GB_PR3: AC004000 128117 AC004000 Human PAC clone
DJ404F18 from Xq23, complete sequence. Homo sapiens 38,75 15-Jan-98
rxa00083 423 GB_HTG1: CNS018OY 168868 AL109769 Homo sapiens
chromosome 14 clone R-501E21, *** SEQUENCING IN Homo sapiens 33,806
15-OCT-1999 PROGRESS ***, in ordered pieces. GB_HTG1: CNS018OY
168868 AL109769 Homo sapiens chromosome 14 clone R-501E21, ***
SEQUENCING IN Homo sapiens 33,806 15-OCT-1999 PROGRESS ***, in
ordered pieces. GB_PR3: HS516C23 116685 Z93021 Human DNA sequence
from clone 516C23 on chromosome 6q12 Homo sapiens 38,582 23-Nov-99
Contains CA repeat (D6S402) and GSSs, complete sequence. rxa00087
651 GB_BA1: PSEBPHABC 6780 M83673 P. pseudoalcaligenes dioxygenase
(bphABC) gene cluster, complete cds. Pseudomonas 39,564 26-Apr-93
pseudoalcaligenes GB_BA1: PSEBPHA 5700 M86348 Pseudomonas sp. LB400
biphenyl dioxygenase (bphA), biphenyl Burkholderia sp. LB400 39,564
18-Jul-97 dioxygenase (bphE), biphenyl dioxygenase (bphF) and
biphenyl dioxygenase (bphG)s, complete cds, and dihydrodiol
dehydrogenase (bphB), partial cds. GB_PAT: E04215 4721 E04215
Benzene dioxygenase gene. Pseudomonas aeruginosa 45,814 29-Sep-97
rxa00093 2346 GB_HTG2: AC007361 36465 AC007361 Homo sapiens clone
NH0144P23, *** SEQUENCING IN Homo sapiens 37,179 23-Apr-99 PROGRESS
***, 1 unordered pieces. GB_PR4: AC006043 189036 AC006043 Homo
sapiens BAC clone NH0538D15 from 7q11.23-q21.1, complete sequence.
Homo sapiens 37,06 20-Feb-99 GB_HTG2: AC007361 36465 AC007361 Homo
sapiens clone NH0144P23, *** SEQUENCING Homo sapiens 37,179
23-Apr-99 IN PROGRESS ***, 1 unordered pieces. rxa00096 426
GB_EST15: AA533064 534 AA533064 nj60d06.s1 NCI_CGAP_Pr9 Homo
sapiens cDNA clone Homo sapiens 39,024 21-Aug-97 IMAGE: 996875,
mRNA sequence. GB_IN1: CELF01G12 34671 U53342 Caenorhabditis
elegans cosmid F01G12. Caenorhabditis elegans 38,06 5-Apr-98
GB_PR3: AC004511 45005 AC004511 Homo sapiens chromosome 5, P1 clone
792C12 (LBNL H22), complete sequence. Homo sapiens 39,163
31-MAR-1998 rxa00097 1299 GB_OM: CFU60590 6726 U60590 Canis
familiaris TTX-resistant sodium channel mRNA, complete cds. Canis
familiaris 39,528 8-Jan-98 GB_GSS15: AQ664394 485 AQ664394
HS_5480_B1_B02_SP6E RPCI-11 Human Male BAC Library Homo sapiens
39,666 23-Jun-99 Homo sapiens genomic clone Plate = 1056 Col = 3
Row = D, genomic survey sequence. GB_BA2: RSAF000233 5984 AF000233
Rhodobacter sphaeroides nitric oxide reductase operon: norC,
Rhodobacter sphaeroides 37,5 6-Jun-97
norB, norQ, norD, nnrT and nnrU genes, complete cds. rxa00101
rxa00108 643 GB_PR4: AC007115 180821 AC007115 Homo sapiens
chromosome 12 clone 917O5, complete sequence. Homo sapiens 35,165
17-Aug-99 GB_PR3: AC004080 129354 AC004080 Homo sapiens PAC clone
DJ0170O19 from 7p15-p21, complete sequence. Homo sapiens 38,56
29-Jan-98 GB_HTG1: HSAJ9613 45302 AJ009613 Homo sapiens chromosome
17 clone cosmid 5L5 map p11, *** SEQUENCING Homo sapiens 39,274
11-Nov-98 IN PROGRESS ***, in unordered pieces. rxa00110 672
GB_PL1: MIATGENB 166924 Y08502 A thaliana mitochondrial genome,
part B. Mitochondrion Arabidopsis 36,391 13-Nov-98 thaliana GB_PL2:
AC010718 87684 AC010718 Arabidopsis thaliana chromosome I BAC
F28O16 Arabidopsis thaliana 36,622 30-OCT-1995 genomic sequence,
complete sequence. GB_PL2: AC007729 106639 AC007729 Arabidopsis
thaliana chromosome II BAC T18C6 Arabidopsis thaliana 35,053
5-Jun-99 genomic sequence, complete sequence. rxa00114 612 GB_OM:
BTMICSD1 362 Z27071 B. taurus (cos1E3) microsatellite DNA (362 bp).
Bos taurus 37,117 10-Aug-95 GB_OM: BTMICSD1 362 Z27071 B. taurus
(cos1E3) microsatellile DNA (362 bp). Bos taurus 36,486 10-Aug-95
rxa00117 714 GB_PL2: AF080249 3194 AF080245 Arabidopsis thaliana
kinesin-like heavy chain (KATD) mRNA, complete cds. Arabidopsis
thaliana 37,846 14-Apr-99 GB_PL2: IG002P16 110946 AF007270
Arabidopsis thaliana BAC IG002P16. Arabidopsis thaliana 37,11
12-Jun-97 GB_PL2: AF080249 3194 AF080249 Arabidopsis thaliana
kinesin-like heavy chain (KATD) mRNA. complete cds. Arabidopsis
thaliana 36,506 14-Apr-59 rxa00118 378 GB_HTG2: AC008043 124844
AC008043 Drosophila melanogaster chromosome 3 clone BACR05A08
Drosophila melanogaster 33,78 2-Aug-99 (D750) RPCI-98 05.A.8 map
94A-94A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 86
unordered pieces. GB_HTG2: AC008043 124844 AC008043 Drosophila
melanogaster chromosome 3 clone BACR05A08 Drosophila melanogaster
33,78 2-Aug-99 (D750) RPCI-98 05.A.8 map 94A-94A strain y; cn bw
sp. *** SEQUENCING IN PROGRESS***, 86 unordered pieces. GB_PR3:
AC004827 129690 AC004827 Homo sapiens PAC clone DJ044L15 from Xq23,
complete sequence. Homo sapiens 32,32 17-OCT-1998 rxa00119 882
GB_PR4: HSU34879 46610 U34879 Human 17-beta-hydroxysteroid
dehydrogenase (EDH17B2) gene, complete cds. Homo sapiens 36,671
14-Jan-99 GB_PR4: HSU34879 46610 U34879 Human
17-beta-hydroxysteroid dehydrogenase (EDH17B2) gene, complete cds.
Homo sapiens 38,345 14-Jan-99 GB_EST37: AW005997 702 AW005997
wz91c01.x1 NCI_CGAP_Brn25 Homo sapiens cDNA clone IMAGE: Homo
sapiens 40,774 10-Sep-99 2566176 3' similar to TR: O08609 O08609
TRANSCRIPTION FACTOR-LIKE PROTEIN 4.;, mRNA sequence. rxa00120 963
GB_BA1: TRU80216 1936 U80216 Thermomicrobium roseum 70 kDa heat
shock protein Hsp70 Thermomicrobium roseum 38 1-Feb-97 (DnaK) gene,
complete cds. GB_HTG1: HS791K14 155318 AL035685 Homo sapiens
chromosome 20 clone RP4-791K14, *** SEQUENCING Homo sapiens 37,277
23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: HS791K14
155318 AL035685 Homo sapiens chromosome 20 clone RP4-791K14, ***
SEQUENCING Homo sapiens 37,277 23-Nov-99 unordered pieces. rxa00121
834 GB_HTG1: HSBA298O6 198847 AL118525 Homo sapiens chromosome 20
clone RP11-298O6, *** SEQUENCING Homo sapiens 36,199 24-Nov-99 IN
PROGRESS ***, in unordered pieces. GB_HTG1: HS791K14 155318
AL035685 Homo sapiens chromosome 20 clone RP4-791K14, ***
SEQUENCING Homo sapiens 36,983 23-Nov-99 IN PROGRESS ***, in
unordered pieces. GB_HTG1: HS791K14 155318 AL035685 Homo sapiens
chromosome 20 clone RP4-791K14, *** SEQUENCING Homo sapiens 36,983
23-Nov-99 IN PROGRESS ***, in unordered pieces. rxa00122 1746
GB_PL1: MZECPN60A 6575 L21007 Corn nuclear-encoded mitochondrial
chaperonin 60 (cpn60I) gene, complete cds. Zea mays 36,098
26-Jul-93 GB_PL1: ZMCPNAGA 2247 Z12114 Z. mays CPNA gene encoding
mitochondrial chaperonin-60. Zea mays 37,702 01-OCT-1992 GB_PL1:
ZMCHHSP60 2138 Z11546 Z. mays mRNA for mitochondrial chaperonin
hsp60. Zea mays 37,721 11-Jun-92 rxa00127 588 GB_PR4: AC005193
108400 AC005193 Homo sapiens clone DJ0655N24, complete sequence.
Homo sapiens 37,5 1-Jul-99 GB_PR4: AC005193 108400 AC005193 Homo
sapiens clone DJ0655N24, complete sequence. Homo sapiens 36,796
1-Jul-99 rxa00128 1827 GB_GSS11: AQ299024 449 AQ299024
HS_3178_B1_B06_T7 CIT Approved Human Genomic Homo sapiens 40,757
15-DEC-1998 Sperm Library D Homo sapiens genomic clone Plate = 3178
Col = 11 Row = D, genomic survey sequence. GB_GSS11: AQ299024 449
AQ299024 HS_3178_B1_B06_T7 CIT Approved Human Genomic Homo sapiens
40,443 15-DEC-1998 Sperm Library D Homo sapiens genomic clone Plate
= 3178 Col = 11 Row = D, genomic survey sequence. rxa00134 693
GB_GSS10: AQ177172 393 AQ177172 HS_3225_A2_E10_MR CIT Approved
Human Genomic Homo sapiens 50 17-OCT-1998 Sperm Library D Homo
sapiens genomic clone Plate = 3225 Col = 20 Row = I, genomic survey
sequence. GB_PR3: AC005726 185215 AC005726 Homo sapiens chromosome
17, clone hRPK.192_H_23, complete sequence. Homo sapiens 37,778
30-OCT-1998 GB_PR3: AC005726 185215 AC005726 Homo sapiens
chromosome 17, clone hRPK.192_H_23, complete sequence. Homo sapiens
38,71 30-OCT-1998 rxa00140 309 GB_VI: OPU75930 131993 U75930 Orgyia
pseudotsugata nuclear polyhedrosis virus complete genome. Orgyia
pseudotsugata 39,007 06-MAR-1998 nuclear polyhedrosis virus
GB_HTG2: AC006319 156299 AC006319 Homo sapiens clone DJ0837C09, ***
SEQUENCING IN Homo sapiens 31,773 23-Apr-99 PROGRESS ***, 1
unordered pieces. GB_HTG2: AC006319 156299 AC006319 Homo sapiens
clone DJ0837C09, *** SEQUENCING IN Homo sapiens 31,773 23-Apr-99
PROGRESS ***, 1 unordered pieces. rxa00141 585 GB_VI: OPU75930
131993 U75930 Orgyia pseudotsugata nuclear polyhedrosis virus
complete genome. Orgyia pseudotsugata 38,079 06-MAR-1998 nuclear
polyhedrosis virus GB_PR4: AC004526 297898 AC004526 Homo sapiens
chromosome 17, Neurofibromatosis 1 locus, complete sequence. Homo
sapiens 37,336 25-Feb-99 GB_PR2: HUMNEUROF 100849 L05367 Human
oligodendrocyte myelin glycoprotein (OMG) exons 1-2;
neurofibromatosis 1 Homo sapiens 37,336 20-Sep-95 (NF1) exons
28-49; ecotropic viral integration site 2B (EVI2B) exons 1-2;
ecotropic viral integration site 2A (EVI2A) exons 1-2; adenylate
kinase (AK3) exons 1-2. rxa00142 600 GB_PR4: HUAC002331 139480
AC002331 Homo sapiens Chromosome 16 BAC clone CIT987SK-A-A-218C7,
Homo sapiens 38,898 23-Nov-99 complete sequence. GB_PR3: AF064861
133965 AF064861 Homo sapiens PAC 128M19 derived from chromosome
21q22.3, containing Homo sapiens 37,182 2-Jun-98 the HMG-14 and
CHD5 genes, complete cds, complete sequence. GB_HTG3: AC009451
165302 AC009451 Homo sapiens chromosome 17 clone 2286_H_12 map 17,
*** SEQUENCING Homo sapiens 33,167 22-Aug-99 IN PROGRESS ***, 26
unordered pieces. rxa00150 897 GB_PR4: AF130343 292721 AF130343
Homo sapiens chromosome 8 clone PAC 87.2 map 8q24.1, complete
sequence. Homo sapiens 36,032 9-Jul-99 GB_HTG4: AC008578 98891
AC008578 Homo sapiens chromosome 5 clone CIT-HSPC_558D4, ***
SEQUENCING Homo sapiens 38,129 31-OCT-1999 IN PROGRESS ***, 143
unordered pieces. GB_HTG4: AC008578 98891 AC008578 Homo sapiens
chromosome 5 clone CIT-HSPC_558D4, *** SEQUENCING Homo sapiens
38,129 31-OCT-1999 IN PROGRESS ***, 143 unordered pieces. rxa00151
720 GB_PL2: AF058914 111767 AF058914 Arabidopsis thaliana BAC
F21E10. Arabidopsis thaliana 36,068 15-Apr-98 GB_PR1: AB019440
200000 AB019440 Homo sapiens DNA for immunoglobulin heavy-chain
variable Homo sapiens 36,517 24-Feb-99 region, complete sequence, 4
of 5. GB_PR2: AP000098 100000 AP000098 Homo sapiens genomic DNA of
21q22.1, GART and AML related, Homo sapiens 39,224 25-Sep-99
Q78C10-149C3 region, segment 1/20, complete sequence. rxa00153 549
GB_PR4: AC006265 177707 AC006265 Homo sapiens chromosome 17, clone
hRPK.566_B_16, complete sequence. Homo sapiens 34,862 28-Jan-99
GB_HTG2: AC007389 207188 AC007389 Homo sapiens clone NH0418H16, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 36,044 5-Jun-99 6
unordered pieces. GB_HTG2: AC007389 207188 AC007389 Homo sapiens
clone NH0418H16, *** SEQUENCING IN PROGRESS ***, Homo sapiens
36,044 5-Jun-99 6 unordered pieces. rxa00154 rxa00155 906 GB_BA2:
AE001707 19518 AE001707 Thermotoga maritima section 19 of 136 of
the complete genome. Thermotoga maritima 36,854 2-Jun-99 GB_PR2:
HS1126I14 19544 AL078589 Human DNA sequence from clone 1126I14 on
chromosome Homo sapiens 36,723 23-Nov-99 6q16.1-16.3. Contains an
STS and GSSs, complete sequence. GB_BA1: MTCY01B2 35938 Z95554
Mycobacterium tuberculosis H37Rv complete genome; segment 72/162.
Mycobacterium 40,435 17-Jun-98 tuberculosis rxa00159 1305 GB_EST38:
AW048718 475 AW048718 UI-M-BH1-amy-d-01-0-UI.s1 NIH_BMAP_M_S2 Mus
musculus Mus musculus 39,789 18-Sep-99 cDNA clone
UI-M-BH1-amy-d-01-0-UI 3', mRNA sequence. GB_EST21: AA993450 381
AA993450 ot32h09.s1 Soares_testis_NHT Homo sapiens cDNA clone Homo
sapiens 38,684 27-Aug-98 IMAGE: 1618529 3', mRNA sequence. GB_BA1:
AB007009 363 AB007009 Cytophaga sp. 16S rRNA gene, partial
sequence. Cytophaga sp. 39,039 13-OCT-1997 rxa00161 585 GB_HTG3:
AC009708 25123 AC009708 Homo sapiens chromosome 8 clone 318_G_5 map
8, Homo sapiens 37,108 28-Aug-99 LOW-PASS SEQUENCE SAMPLING.
GB_HTG3: AC009708 25123 AC009708 Homo sapiens chromosome 8 clone
318_G_5 map 8, Homo sapiens 37,108 28-Aug-99 LOW-PASS SEQUENCE
SAMPLING. GB_PR3: HSN104C4 40203 Z83855 Human DNA sequence from
clone N104C4 on chromosome 22 Contains Homo sapiens 37,634
23-Nov-99 GSSs, complete sequence. rxa00162 477 GB_HTG1: CEY94A7
41009 Z99294 Caenorhabditis elegans chromosome V clone Y94A7, ***
SEQUENCING Caenorhabditis elegans 41,502 18-Sep-97 IN PROGRESS ***,
in unordered pieces. GB_HTG1: CEY94A7 41009 Z99294 Caenorhabditis
elegans chromosome V clone Y94A7, *** SEQUENCING Caenorhabditis
elegans 41,502 18-Sep-97 IN PROGRESS ***, in unordered pieces.
GB_BA2: AE001182 11228 AE001182 Borrelia burgdorferi (section 68 of
70) of the complete genome. Borrelia burgdorferi 39,655 15-DEC-1997
rxa00167 621 GB_HTG7: AC007937 206265 AC007937 Mus musculus
chromosome 10 clone RP21-536F4 map 10, *** SEQUENCING Mus musculus
37,092 09-DEC-1999 IN PROGRESS ***, 6 unordered pieces. GB_RO:
MMU6590 6429 AJ006590 Mus musculus mRNA for GANP protein. Mus
musculus 38,678 2-Jun-99 GB_HTG3: AC008852 116219 AC008852 Homo
sapiens chromosome 5 clone CITB-H1_2176I21, *** SEQUENCING Homo
sapiens 35,691 3-Aug-99 IN PROGRESS ***, 13 unordered pieces.
rxa00169 2196 GB_GSS3: B11032 896 B11032 T17F10-T7 TAMU Arabidopsis
thaliana genomic clone T17F10, Arabidopsis thaliana 42,024
14-MAY-1997 genomic survey sequence. GB_GSS3: B10120 909 B10120
T27N10-Sp6.1 TAMU Arabidopsis thaliana genomic clone T27N10,
Arabidopsis thaliana 41,581 14-MAY-1997 genomic survey sequence.
GB_GSS3: B09409 916 B09409 T27M2-Sp6 TAMU Arabidopsis thaliana
genomic clone T27M2, Arabidopsis thaliana 41,356 14-MAY-1997
genomic survey sequence. rxa00170 1977 GB_GSS8: AQ027582 456
AQ027582 CIT-HSP-2325M20.TR CIT-HSP Homo sapiens genomic Homo
sapiens 40,749 30-Jun-98 clone 2325M20, genomic survey sequence.
GB_GSS6: AQ833529 484 AQ833529 HS_5304_B2_C02_T7A RPCI-11 Human
Male BAC Library Homo sapiens Homo sapiens 38,017 27-Aug-99 genomic
clone Plate = 880 Col = 4 Row = F, genomic survey sequence. GB_PR2:
HSM800174 2326 AL049389 Homo sapiens mRNA; cDNA DKFZp586O0118 (from
clone DKFZp586O0118). Homo sapiens 37,556 21-MAY-1999 rxa00171 281
GB_EST38: AL118463 279 AL118463 w9112a43 Beddington mouse dissected
endoderm Mus musculus cDNA Mus musculus 50 23-Sep-99 clone
528_12E22 5', mRNA sequence. GB_EST15: AA499834 419 AA499834
vg05e06.r1 Soares mouse NbMH Mus musculus cDNA clone Mus musculus
39,801 1-Jul-97 IMAGE: 860482 5', mRNA sequence. GB_EST24: AI211527
431 AI211527 p0h01a1.r1 Aspergillus nidulans 24 hr asexual
developmental Emericella nidulans 41,584 19-OCT-1998 and vegetative
cDNA lambda zap library Emericella nidulans cDNA clone p0h01a1 5',
mRNA sequence. rxa00173 456 GB_PR3: AC004400 33367 AC004400 Homo
sapiens chromosome 19, cosmid F24069, complete sequence. Homo
sapiens 38,902 12-MAR-1998 GB_PL1: VFU14956 1474 U14956 Vicia faba
ferredoxin NADP+ reductase precursor (fnr) mRNA, complete cds.
Vicia faba 38,753 28-Sep-84 GB_PR3: AC004400 33367 AC004400 Homo
sapiens chromosome 19, cosmid F24069, complete sequence. Homo
sapiens 40,515 12-MAR-1998 rxa00174 408 GB_PL2: AF075293 4332
AF075293 Candida albicans strain 1161 agglutinin-like protein 6
(ALS6) gene, complete cds. Candida albicans 41,235 2-Jul-99 GB_PL2:
JSPCHS1 1525 X94995 Juglans nigra x Juglans regia mRNA for chalcone
synthase (CHS1). Juglans nigra x Juglans 39,558 19-Nov-99 regia
GB_PL2: JSPCHS2 1534 X94706 Juglans nigra x Juglans regia mRNA for
chalcone synthase (CHS2). Juglans nigra x Juglans 38,821 19-Nov-99
regia rxa00175 rxa00179 582 GB_BA1: CGPUTP 3791 Y09163 C.
glutamicum putP gene. Corynebacterium 100 8-Sep-97 glutamicum
GB_IN2: L76038 2421 L76038 Anopheles gambiae prophenoloxidase mRNA,
complete cds. Anopheles gambiae 35,751 23-Jul-98 GB_IN2: AF031626
8486 AF031626 Anopheles gambiae prophenoloxidase (AgProPO) gene,
complete cds. Anopheles gambiae 36,395 5-Jan-99 rxa00180 663
GB_BA1: CGPUTP 3791 Y09163 C. glutamicum putP gene. Corynebacterium
100 8-Sep-97 glutamicum
GB_HTG1: HS120G22 57021 AL031847 Homo sapiens chromosome 1 clone
RP1-120G22, *** SEQUENCING Homo sapiens 35,976 23-Nov-99 IN
PROGRESS ***, in unordered pieces. GB_HTG1: HS120G22 57021 AL031847
Homo sapiens chromosome 1 clone RP1-120G22, *** SEQUENCING Homo
sapiens 35,976 23-Nov-99 IN PROGRESS ***, in unordered pieces.
rxa00183 975 GB_IN2: AF049132 16005 AF049132 Florometra
serratissima mitochondrion, complete genome. Mitochondrion
Florometra 33,71 15-Jan-99 serratissima GB_IN1: MTCE 13794 X54252
C. elegans complete mitochondrial genome. Mitochondrion 35,036
30-Nov-97 Caenorhabditis elegans GB_IN2: AF049132 16005 AF049132
Florometra serratissima mitochondrion, complete genome.
Mitochondrion Florometra 36,021 15-Jan-99 serratissima rxa00185
2751 GB_EST31: AI693167 500 AI693167 wd66c11.x1 NCI_CGAP_Lu24 Homo
sapiens cDNA clone IMAGE: Homo sapiens 37,8 2-Jun-99 2336756 3'
similar to SW: HIOM_BOVIN P10950 HYDROXYINDOLE
O-METHYLTRANSFERASE;, mRNA sequence. GB_GSS1: CNS010IZ 1000
AL099029 Drosophila melanogaster genome survey sequence Drosophila
melanogaster 35,158 26-Jul-99 SP6 end of BAC BACN04K17 of DrosBAC
library from Drosophila melanogaster (fruit fly), genomic survey
sequence. GB_EST31: AI693167 500 AI693167 wd68c11.x1 NCI_CGAP_Lu24
Homo sapiens cDNA clone Homo sapiens 39,052 2-Jun-99 SW: HIOM_BOVIN
P10950 HYDROXYINDOLE IMAGE: 2336756 3' similar to
O-METHYLTRANSFERASE;, mRNA sequence. rxa00194 564 GB_GSS10:
AQ192671 396 AQ192671 HS_2251_B2_A04_MF CIT Approved Human Genomic
Sperm Library D Homo sapiens 44,24 4-Nov-98 Homo sapiens genomic
clone Plate = 2251 Col = 8 Row = B, genomic survey sequence.
GB_GSS8: AQ044307 644 AQ044307 CIT-HSP-2331N9.TR CIT-HSP Homo
sapiens genomic clone 2331N9, Homo sapiens 36,15 14-Jul-98 genomic
survey sequence. GB_EST36: AI925874 564 AI925874 wo20d11.x1
NCI_CGAP_Pan1 Homo sapiens cDNA clone IMAGE: Homo sapiens 45,588
2-Sep-99 2455893 3' similar to TR: O67849 O67849 GTP-BINDING
PROTEIN.;, mRNA sequence. rxa00197 1335 GB_GSS12: AQ399208 436
AQ399208 mgxb0001M23f CUGI Rice Blast BAC Library Magnaporthe
grisea Magnaporthe grisea 63,529 06-MAR-1999 genomic clone
mgxb0001M23f, genomic survey sequence. GB_GSS12: AQ398449 472
AQ398449 mgxb0001P11f CUGI Rice Blast BAC Library Magnaporthe
grisea Magnaporthe grisea 49,58 06-MAR-1999 genomic clone
mgxb0001P11f, genomic survey sequence. GB_OM: BTMMP9 2350 X78324 B.
taurus bmmp9 mRNA for matrix metalloproteinase. Bos taurus 40,44
30-MAR-1995 rxa00199 1542 GB_BA1: AB024708 8734 AB024708
Corynebacterium glutamicum gltB and gltD genes for glutamine 2-
Corynebacterium 36,237 13-MAR-1999 oxoglutarate aminotransferase
large and small subunits, complete cds. glutamicum GB_HTG2:
AC007837 103949 AC007837 Drosophila melanogaster chromosome 2 clone
BACR04I07 Drosophila melanogaster 36,045 2-Aug-99 (D644) RPCI-98
04.I.7 map 57B2-B3 strain y; cn bw sp, *** SEQUENCING IN
PROGRESS***, 49 unordered pieces. GB_HTG2: AC007837 103949 AC007837
Drosophila melanogaster chromosome 2 clone BACR04I07 Drosophila
melanogaster 36,045 2-Aug-99 (D644) RPCI-98 04.I.7 map 57B2-B3
strain y: cn bw sp. *** SEQUENCING IN PROGRESS***, 49 unordered
pieces. rxa00200 3561 GB_BA2: MSU46844 16951 U46844 Mycobacterium
smegmatis catalase-peroxidase (katG), putative arabinosyl
Mycobacterium smegmatis 53,937 12-MAY-1997 transferase (embC, embA,
embB), genes complete cds and putative propionyl-coA carboxylase
beta chain (pccB) genes, partial cds. GB_BA2: MAU66560 7853 U66560
Mycobacterium avium EmbR (embR), EmbA (embA) and EmbB Mycobacterium
avium 52,241 8-Nov-96 (embB) genes, complete cds. GB_BA1: MTY13D12
37085 Z80343 Mycobacterium tuberculosis H37Rv complete genome;
segment 156/162. Mycobacterium 52,812 17-Jun-98 tuberculosis
rxa00207 441 GB_PR3: HTCRBCHR9 216293 AF029308 Homo sapiens
chromosome 9 duplication of the T cell receptor beta Homo sapiens
39,286 13-Apr-98 locus and trypsinogen gene families. GB_PR3:
HTCRBCHR9 216293 AF029308 Homo sapiens chromosome 9 duplication of
the T cell receptor beta Homo sapiens 37,116 13-Apr-98 locus and
trypsinogen gene families. rxa00211 786 GB_PR2: HSU81831 38674
U81831 Human cosmid LL12NCO1-67C6, ETV6 gene, intron 1A, partial
sequence. Homo sapiens 35,509 3-Jan-97 GB_RO: MUSKROX2S2 2868
M28845 Mus musculus zinc finger protein (Krox-24) gene, exon 2. Mus
musculus 40,566 21-MAY-1996 GB_HTG2: AC007440 120642 AC007440
Drosophila melanogaster chromosome 2 clone BACR37I09 (D593)
Drosophila melanogaster 36,753 2-Aug-99 RPCI-98 37.I.9 map 49A-49B
strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 103 unordered
pieces. rxa00218 rxa00220 627 GB_BA1: ASU04436 4668 U04436 Anabaena
sp. PCC 7120 putative polyketide synthase gene, complete cds.
Anabaena sp. 33,766 21-DEC-1993 GB_RO: AF068199 3490 AF068199 Mus
musculus D-dopachrome tautomerase gene, complete cds. Mus musculus
38,833 26-Aug-98 GB_RO: AF068199 3490 AF068199 Mus musculus
D-dopachrome tautomerase gene, complete cds. Mus musculus 34,776
26-Aug-98 rxa00222 1269 GB_PL1: AB011477 78181 AB011477 Arabidopsis
thaliana genomic DNA, chromosome 5, Arabidopsis thaliana 36,766
20-Nov-99 P1 clone: MHK7, complete sequence. GB_EST17: AA615900 427
AA615900 vo91b05.r1 Barstead mouse irradiated colon MPLRB7 Mus
musculus 39,782 07-OCT-1997 Mus musculus cDNA clone IMAGE: 1066449
5' similar to SW: MUCL_RAT P98089 INTESTINAL MUCIN-LIKE GB_EST38:
AW039188 486 AW039188 EST281423 tomato mixed elicitor, BTI
Lycopersicon esculentum Lycopersicon esculentum 41,286 18-OCT-1999
PROTEIN;, mRNA sequence. cDNA clone cLET9F17, mRNA sequence.
rxa00230 843 GB_PR3: AC005255 94343 AC005255 Homo sapiens
chromosome 19, CIT-HSP-146e8, complete sequence. Homo sapiens 35,99
6-Jul-98 GB_PR3: AC005255 94343 AC005255 Homo sapiens chromosome
19, CIT-HSP-146e8, complete sequence. Homo sapiens 38,175 6-Jul-98
rxa00232 633 GB_HTG2: AC007118 200000 AC007118 Homo sapiens
chromosome 4, *** SEQUENCING IN Homo sapiens 36,772 19-MAR-1999
PROGRESS ***, 45 unordered pieces. GB_HTG2: AC007118 200000
AC007118 Homo sapiens chromosome 4, *** SEQUENCING IN Homo sapiens
36,772 19-MAR-1999 PROGRESS ***, 45 unordered pieces. GB_GSS1:
CNS004WZ 978 AL055537 Drosophila melanogaster genome survey
sequence TET3 end of BAC # Drosophila melanogaster 34,518 3-Jun-99
BACR11G02 of RPCI-98 library from Drosophila melanogaster (fruit
fly), genomic survey sequence. rxa00233 517 GB_BA1: AB006206 7443
AB006206 Streptomyces griseus AmfR, AmfA and AmfB genes and 4 ORFs,
complete cds. Streptomyces griseus 38,69 5-Feb-99 GB_PR4: AC006999
112878 AC006999 Homo sapiens clone NH0462A19, complete sequence.
Homo sapiens 40,244 17-Jul-99 GB_HTG2: AC007042 132400 AC007042
Homo sapiens clone NH0399H17, *** SEQUENCING IN Homo sapiens 40,244
06-MAR-1999 PROGRESS ***, 5 unordered pieces. rxa00234 663 GB_PAT:
E13059 3480 E13059 gDNA encoding cytochrome b5. unidentified 40,091
24-Jun-98 GB_PL1: AB022444 2104 AB022444 Mortierella alpina gene
for cytochrome b5, complete cds. Mortierella alpina 42,314
14-Jul-99 GB_GSS9: AQ112619 443 AQ112619 CIT-HSP-2371D11.TR CIT-HSP
Homo sapiens genomic clone 2371D11, Homo sapiens 39,623 29-Aug-98
genomic survey sequence. rxa00236 849 GB_BA1: CGPROMF34 60 X90361
C. glutamicum DNA for promoter fragment F34. Corynebacterium 98,333
4-Nov-96 glutamicum GB_IN1: CEF56G4 38062 Z81552 Caenorhabditis
elegans cosmid F56G4, complete sequence. Caenorhabditis elegans
36,19 08-OCT-1999 GB_EST16: C51159 370 C51159 C51159 Yuji Kohara
unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis
elegans 41,096 18-OCT-1999 Caenorhabditis elegans cDNA clone
yk491h3 5', mRNA sequence. rxa00237 501 GB_GSS9: AQ148605 511
AQ148605 HS_3137_B2_A11_T7 CIT Approved Human Genomic Sperm Homo
sapiens 37,959 08-OCT-1988 Library D Homo sapiens genomic clone
Plate = 3137 Col = 22 Row = B, genomic survey sequence. GB_GSS11:
AQ274889 622 AQ274889 RPCI-5-1111N8T7 RPCI-5 Homo sapiens genomic
clone Homo sapiens 44,628 10-Nov-98 RPCI-5-1111N8T7, genomic survey
sequence. GB_GSS11: AQ274889 622 AQ274889 RPCI-5-1111N8T7 RPCI-5
Homo sapiens genomic clone Homo sapiens 37,321 10-Nov-98
RPCI-5-1111N8T7, genomic survey sequence. rxa00238 492 GB_PL2:
PBU91560 2605 U91560 Paracoccidioides brasiliensis heat shock
protein 70 (Hsp70) gene, complete cds. Paracoccidioides 37,137
12-MAR-1999 brasiliensis GB_HTG6: AC007957 212658 AC007957 Homo
sapiens, *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. Homo
sapiens 38,285 26-Nov-99 GB_PR4: AC009288 140876 AC009288 Homo
sapiens, complete sequence. Homo sapiens 36,575 19-Nov-99 rxa00239
708 GB_PL2: PBU91560 2605 U91560 Paracoccidioides brasiliensis heat
shock protein 70 (Hsp70) gene, complete cds. Paracoccidioides
45,545 12-MAR-1999 brasiliensis GB_BA2: CJU96452 1450 U96452
Campylobacter jejuni major outer membrane porin gene, complete cds.
Campylobacter jejuni 37,197 02-DEC-1998 GB_RO: RATPF4 1675 M15254
Rat platelet factor 4 (PF4) gene. Rattus norvegicus 35,014
27-Apr-93 rxa00240 333 GB_BA1: CGLYSI 4232 X60312 C. glutamicum
lysI gene for L-lysine permease. Corynebacterium 46,207 30-Jan-92
glutamicum GB_PR3: AC005358 184886 AC005358 Homo sapiens chromosome
17, clone hRPK.746_E_8, complete sequence. Homo sapiens 35,843
29-Aug-98 GB_BA1: CGLYSI 4232 X60312 C. glutamicum lysI gene for
L-lysine permease. Corynebacterium 42,025 30-Jan-92 glutamicum
rxa00242 1401 GB_BA1: CGLYSI 4232 X60312 C. glutamicum lysI gene
for L-lysine permease. Corynebacterium 100 30-Jan-92 glutamicum
GB_PR3: HSJ514B11 100494 AL049554 Human DNA sequence from clone
514B11 on chromosome 6q16.1-21 Homo sapiens 37,01 23-Nov-99
Contains an EST, STSs and GSSs, complete sequence. GB_HTG3:
AC009393 137353 AC009393 Drosophila melanogaster chromosome 3 clone
BACR17F05 (D977) Drosophila melanogaster 39,6 27-Aug-99 RPCI-98
17.F.5 map 87D-87D strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 111 unordered pieces. rxa00244 759 GB_HTG4: AC011290 148409
AC011290 Homo sapiens clone NH0064I02, *** SEQUENCING IN PROGRESS
***, Homo sapiens 38,102 15-OCT-1999 3 unordered pieces. GB_HTG4:
AC011290 148409 AC011290 Homo sapiens clone NH0064I02, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 38,102 15-OCT-1999 3
unordered pieces. GB_EST23: AI077162 527 AI077162 TENU338.4 T.
cruzi epimastigote normalized cDNA Library Trypanosoma cruzi 38,847
10-Aug-98 Trypanosoma cruzi cDNA clone 28o6 5' similar to
TRANSPLANTATION ANTIGEN P35B sp|P23591|TUM3_MOUSE, mRNA sequence.
rxa00245 1608 GB_HTG2: AC007644 141048 AC007644 Homo sapiens
chromosome 17 clone hRPK.19_F_16 map Homo sapiens 36,929
23-MAY-1999 17, *** SEQUENCING IN PROGRESS ***, 17 unordered
pieces. GB_HTG2: AC007644 141048 AC007644 Homo sapiens chromosome
17 clone hRPK.19_F_16 map 17, *** SEQUENCING Homo sapiens 36,929
23-MAY-1999 IN PROGRESS ***, 17 unordered pieces. GB_HTG2: AC007644
141048 AC007644 Homo sapiens chromosome 17 clone hRPK.19_F_16 map
17, *** SEQUENCING Homo sapiens 34,025 23-MAY-1999 IN PROGRESS ***
17, unordered pieces. rxa00247 1050 GB_PR2: AP000119 100000
AP000119 Homo sapiens genomic DNA of 21q22.1, GART and AML related,
SLC5A3-f4A4 Homo sapiens 36,187 25-Sep-99 region, segment 2/8,
complete sequence. GB_PR2: AP000051 100000 AP000051 Homo sapiens
genomic DNA, chromosome 21q22.1, Homo sapiens 36,187 20-Nov-99
segment 22/28, complete sequence. GB_PR2: AP000166 100000 AP000166
Homo sapiens genomic DNA, chromosome 21q22.1, D21S226-AML region,
Homo sapiens 37,942 20-Nov-99 clone B2344F14-f50E8, segment 2/9,
complete sequence. rxa00248 846 GB_PR4: AC006464 99908 AC006484
Homo sapiens BAC clone NH0436C12 from 2, complete sequence. Homo
sapiens 36,797 22-OCT-1999 GB_PR4: AC006238 211945 AC006238 Homo
sapiens chromosome 18, clone hRPK.474_N_24, complete sequence. Homo
sapiens 32,896 31-Jan-99 GB_PR4: AC006238 211945 AC006238 Homo
sapiens chromosome 18, clone hRPK.474_N_24, complete sequence. Homo
sapiens 34,438 31-Jan-99 rxa00250 870 GB_GSS10: AQ244736 469
AQ244736 HS_2056_B1_F03_T7 CIT Approved Human Genomic Sperm Homo
sapiens 36,31 03-OCT-1998 Library D Homo sapiens genomic clone
Plate = 2056 Col = 5 Row = L, genomic survey sequence. GB_PAT:
I07323 340 I07323 Sequence 5 from Patent EP 0331961. Unknown.
38,125 02-DEC-1994 GB_PR1: HS11Q13RP 10777 Y12377 H. sapiens
FGF/Int-2 gene upstream flanking region. Homo sapiens 36,155
17-Apr-97 rxa00252 366 GB_BA1: MTCY20G9 37218 Z77162 Mycobacterium
tuberculosis H37Rv complete genome; segment 25/162. Mycobacterium
39,554 17-Jun-98 tuberculosis GB_BA1: MTV004 69350 AL009198
Mycobacterium tuberculosis H37Rv complete genome; segment 144/162.
Mycobacterium 40,443 18-Jun-98 tuberculosis GB_BA1: MTV004 69350
AL009198 Mycobacterium tuberculosis H37Rv complete genome; segment
144/162. Mycobacterium 41,803 18-Jun-98 tuberculosis rxa00256 894
GB_PR4: AC005343 137213 AC005343 Homo sapiens Chromosome 12p13.3
BAC RPCI11-21K20 (Roswell Park Homo sapiens 36,436 2-Apr-99 Cancer
Institute Human BAC Library) complete sequence. GB_PR3: AC003005
45084 AC003005 Human DNA from chromosome 19-specific cosmid F25419
containing ZNF Homo sapiens 36,395 22-OCT-1997 gene family members,
genomic sequence, complete sequence. GB_HTG3: AC007930 67668
AC007930 Drosophila melanogaster chromosome 2 clone BACR49A06
(D772) Drosophila melanogaster 32,503 20-Sep-99 RPCI-98 49.A.6 map
43B-43B strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 40
unordered pieces. rxa00257 579 GB_PR4: AC005343 137213 AC005343
Homo sapiens Chromosome 12p13.3 BAC RPCI11-21K20 (Roswell Park
Cancer Homo sapiens 37,063 2-Apr-99 Institute Human BAC Library)
complete sequence. GB_HTG1: HS1096J16 194423 AL121721 Homo sapiens
chromosome 20 clone RP5-1096J16, *** SEQUENCING IN Homo sapiens
37,217 23-Nov-99
PROGRESS ***, in unordered pieces. GB_HTG1: HS1096J16 194423
AL121721 Homo sapiens chromosome 20 clone RP5-1096J16, ***
SEQUENCING IN Homo sapiens 37,217 23-Nov-99 PROGRESS ***, in
unordered pieces. rxa00258 795 GB_PR3: HSJ747H23 114201 AL049699
Human DNA sequence from clone 747H23 on chromosome 6q13-15,
Contains the 3' Homo sapiens 36,469 23-Nov-99 part of the ME1 gene
for malic enzyme 1, soluble (NADP-dependent malic enzyme, malate
oxidoreductase, EC 1.1.1.40), a novel gene and the 5' part of the
gene for N-acetylglucosamine-phosphate mutase. Contains ESTs, STSs,
GSSs and two putative CpG islands, complete sequence. GB_HTG2:
H5J202D23 175496 AL121716 Homo sapiens chromosome 6 clone
RP1-202D23 map q14.1-15, *** SEQUENCING Homo sapiens 36,469
03-DEC-1999 IN PROGRESS ***, in unordered pieces. GB_HTG2:
HSJ202D23 175496 AL121716 Homo sapiens chromosome 6 clone
RP1-202D23 map q14.1-15, *** SEQUENCING Homo sapiens 36,469
03-DEC-1999 IN PROGRESS ***, in unordered pieces. rxa00260 1299
GB_PR3: HS360B4 23388 AL031716 Human DNA sequence from clone 360B4
on chromosome 16. Contains part of Homo sapiens 36,145 23-Nov-99 a
gene for a PUTATIVE novel protein similar to predicted bacterial
and worm proteins and ESTs, complete sequence. GB_EST19: AA741904
423 AA741904 LmLv39p3/71A Leishmania major promastigote full length
cDNA library from early Leishmania major 39,192 10-DEC-1998
logarithmic stage (day 3) Leishmania major cDNA clone 71A 5', mRNA
sequence. GB_PR3: HS360B4 23388 AL031716 Human DNA sequence from
clone 360B4 on chromosome 16. Contains part of Homo sapiens 39,494
23-Nov-99 a gene for a PUTATIVE novel protein similar to predicted
bacterial and worm proteins and ESTs, complete sequence. rxa00264
rxa00267 441 GB_GSS10: AQ258013 761 AQ258013 nbxb0019H05f CUGI Rice
BAC Library Oryza sativa genomic clone nbxb0019H05f, Oryza sativa
52,033 23-OCT-1998 genomic survey sequence. GB_EST10: AA167894 552
AA167894 CpEST 021 uniZAPCpIOWAsporoLib1 Cryptosporidium parvum
cDNA 5' similar Cryptosporidium parvum 40,462 19-DEC-1996 to
lactate dehydrogenase, mRNA sequence. GB_HTG3: AC011591 129431
AC011591 Homo sapiens chromosome 17 clone 118_B_18 map 17, ***
SEQUENCING IN Homo sapiens 35,469 07-OCT-1999 PROGRESS ***, 25
unordered pieces. rxa00271 1113 GB_PL1: CHTRP1 3480 X70035 C.
heterostrophus gene for trifunctional tryptophan synthase.
Cochliobolus 41,636 31-OCT-1996 heterostrophus GB_VI: FLU47643 1492
U47643 Feline leukemia virus Notch2 gene, clone FeLV/Notch2-AP
(subgenomic), partial cds. Feline leukemia virus 37,869 25-OCT-1996
GB_VI: FLU47644 1641 U47644 Feline leukemia virus Notch2 gene,
clone FeLV/Notch2-B, partial cds. Feline leukemia virus 36,441
25-OCT-1996 rxa00272 495 GB_GSS8: AQ041841 373 AQ041841
CIT-HSP-2335L1.TR CIT-HSP Homo sapiens genomic clone 2335L1,
genomic Homo sapiens 45,455 14-Jul-98 survey sequence. GB_GSS13:
AQ429301 591 AQ429301 CITBI-E1-2562H16.TR CITBI-E1 Homo sapiens
genomic clone 2562H16, Homo sapiens 63,636 24-MAR-1999 genomic
survey sequence. GB_GSS10: AQ237541 667 AQ237541 RPCI11-61O21.TJB.1
RPCI-11 Homo sapiens genomic clone RPCI-11-61O21, Homo sapiens
62,222 21-Apr-99 genomic survey sequence. rxa00273 1236 GB_BA1:
CGBETPGEN 2339 X93514 C. glutamicum betP gene. Corynebacterium
44,056 8-Sep-97 glutamicum GB_PR2: HS142F18 141672 AL031073 Human
DNA sequence from clone 142F18 on chromosome Xq26.3-27.2 Contains
Homo sapiens 44,643 23-Nov-99 part of a gene similar to
melanoma-associated antigen, EST, GSS and an inverted repeat,
complete sequence. GB_IN2: AC007177 101320 AC007177 Drosophila
melanogaster, chromosome 2R, region 59C1-59C5, P1 clones DS06821
Drosophila melanogaster 36,721 27-MAR-1999 and DS02186, complete
sequence. rxa00274 2733 GB_HTG3: AC011675 98026 AC011675 Homo
sapiens clone 10_J_17, LOW-PASS SEQUENCE SAMPLING. Homo sapiens
35,405 10-OCT-1999 GB_HTG3: AC011675 98026 AC011675 Homo sapiens
clone 10_J_17, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 35,405
10-OCT-1999 GB_HTG3: AC010598 174019 AC010598 Homo sapiens
chromosome 5 clone CIT-HSPC_560O9, *** SEQUENCING IN Homo sapiens
36,908 16-Sep-99 PROGRESS ***, 50 unordered pieces. rxa00275 582
GB_GSS14: AQ574926 666 AQ574926 nbxb0086K14f CUGI Rice BAC Library
Oryza sativa genomic clone nbxb0086K14f, Oryza sativa 33,83
2-Jun-99 genomic survey sequence. GB_HTG2: AC004396 43686 AC004396
Homo sapiens, *** SEQUENCING IN PROGRESS ***, 2 unordered pieces.
Homo sapiens 38,298 19-Jul-99 GB_HTG2: AC004396 43686 AC004396 Homo
sapiens, *** SEQUENCING IN PROGRESS ***, 2 unordered pieces. Homo
sapiens 38,298 19-Jul-99 rxa00276 465 GB_PL1: SC9952X 29286 Z49212
S. cerevisiae chromosome XIII cosmid 9952. Saccharomyces cerevisiae
37,118 11-Aug-97 GB_PL1: S45357 4017 S45357 PSE-1 = protein
secretion enhancer [Saccharomyces cerevisise, Genomic, 4017 nt].
Saccharomyces cerevisiae 41,394 08-MAY-1993 GB_PL1: SCPSE1G 4017
Z11538 S. cerevisiae PSE-1 gene. Saccharomyces cerevisiae 41,394
13-Aug-96 rxa00279 1509 GB_HTG3: AC009911 99707 AC009911 Drosophila
melanogaster chromosome 2 clone BACR01N17 (D1036) RPCI-98
Drosophila melanogaster 33,023 05-OCT-1999 01.N.17 map 38A- 38A
strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 69 unordered
pieces. GB_HTG3: AC009911 99707 AC009911 Drosophila melanogaster
chromosome 2 clone BACR01N17 (D1036) RPCI-98 Drosophila
melanogaster 33,023 05-OCT-1999 01.N.17 map 38A- 38A strain y; cn
bw sp, *** SEQUENCING IN PROGRESS ***, 69 unordered pieces.
GB_HTG4: AC008397 230451 AC008397 Homo sapiens chromosome 19 clone
CIT-HSPC_251H24, ***, SEQUENCING IN Homo sapiens 37,432 31-OCT-1999
PROGRESS ***, 81 unordered pieces. rxa00282 889 GB_PR3: HSB11B7
37290 Z82171 Human DNA sequence from cosmid B11B7 on chromosome 22
contains ESTs. Homo sapiens 35,845 23-Nov-99 GB_PR3: HSB11B7 37290
Z82171 Human DNA sequence from cosmid B11B7 on chromosome 22
contains ESTs. Homo sapiens 37,126 23-Nov-99 GB_RO: RATMTA 4197
L39264 Rattus norvegicus beta-2 adrenergic receptor gene, complete
cds and promoter region. Rattus norvegicus 41,259 23-Feb-96
rxa00283 1155 GB_GSS8: AQ030327 411 AQ030327 HS_2177_B1_H06_MF CIT
Approved Human Genomic Sperm Library D Homo Homo sapiens 37,656
1-Jul-98 sapiens genomic clone Plate = 2177 Col = 11 Row = P,
genomic survey sequence. GB_PR3: HSL118GB 27858 Z68883 Human DNA
sequence from cosmid L118G10, Huntington's Disease Region, Homo
sapiens 37,412 23-Nov-99 chromosome 4p16.3. GB_PR3: HSJ513G18
110770 AL109760 Human DNA sequence from clone 513G18 on chromosome
4, complete sequence. Homo sapiens 37,412 23-Nov-99 rxa00286 687
GB_EST10: AA157040 414 AA157040 zo51c05.r1 Stratagene endothelial
cell 937223 Homo sapiens cDNA clone IMAGE: Homo sapiens 37,136
11-DEC-1996 590408 5' similar to gb: M84711 40S RIBOSOMAL PROTEIN
S3A (HUMAN);, mRNA sequence. GB_EST11: AA213935 629 AA213935
zn57a04.r1 Stratagene muscle 937209 Homo sapiens cDNA clone IMAGE:
Homo sapiens 34,219 1-Aug-97 562254 5' similar to gb: M84711 40S
RIBOSOMAL PROTEIN S3A (HUMAN);, mRNA sequence. GB_STS: BLYBG 459
L43987 Hordeum vulgare (clone ABG380) chromosome 4H, 6H, 7H STS
mRNA, Hordeum vulgare 37,786 27-Jul-95 sequence tagged site.
rxa00294 552 GB_PR2: HSAC000121 93163 AC000121 Human BAC clone
RG249A12 from 7q22, complete sequence. Homo sapiens 36,735
31-Jan-97 GB_BA2: CGU31281 1614 U31281 Corynebacterium glutamicum
biotin synthase (bioB) gene, complete cds. Corynebacterium 100
21-Nov-96 glutamicum GB_PR2: HSAC000121 93163 AC000121 Human BAC
clone RG249A12 from 7q22, complete sequence. Homo sapiens 37,662
31-Jan-97 rxa00297 1035 GB_HTG2: AC006938 82665 AC006938 Drosophila
melanogaster chromosome 2 clone DS01630 (D506) map 60C7-60C8
Drosophila melanogaster 37,241 2-Aug-99 strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 9 unordered pieces. GB_HTG2: AC007116
25478 AC007116 Drosophila melanogaster chromosome 2 clone DS04467
(D447) map 60C6-60C8 Drosophila melanogaster 38,63 30-Jul-99 strain
y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 5 unordered pieces.
GB_HTG2: AC006938 82665 AC006938 Drosophila melanogaster chromosome
2 clone DS01630 (D506) map 60C7-60C8 Drosophila melanogaster 37,241
2-Aug-99 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 9
unordered pieces. rxa00320 303 GB_GSS14: AQ585202 564 AQ585202
RPCI-11-451L11.TJ RPCI-11 Homo sapiens genomic clone
RPCI-11-451L11, Homo sapiens 37,319 7-Jun-99 genomic survey
sequence. GB_BA1: NGPILC1 3144 Y13022 N. gonorrhoeae pilC1 gene,
strain 640. Neisseria gonorrhoeae 38,667 07-OCT-1997 GB_BA1:
NGPILC1 3144 Y13022 N. gonorrhoeae pilC1 gene, strain 640.
Neisseria gonorrhoeae 36 07-OCT-1997 rxa00321 rxa00322 1227
GB_HTG2: AC007533 153053 AC007533 Homo sapiens chromosome 16 clone
474B12, *** SEQUENCING IN Homo sapiens 39,469 12-MAY-1999 PROGRESS
***, 5 ordered pieces. GB_HTG2: AC007533 153053 AC007533 Homo
sapiens chromosome 16 clone 474B12, *** SEQUENCING IN Homo sapiens
39,469 12-MAY-1999 PROGRESS ***, 5 ordered pieces. GB_PR2:
HUM133K23 82512 AC000061 Human BAC clone 133K23 from 7q31.2,
complete sequence. Homo sapiens 38,95 14-Nov-96 rxa00325 768
GB_BA2: CDU73860 1273 U73860 Corynebacterium diphtheriae heme
oxygenase homolog (hmuO) gene, complete cds. Corynebacterium 52,604
7-Feb-97 diphtheriae GB_BA1: AB019621 652 AB019621 Corynebacterium
diphtheriae mRNA for Heme oxygenase, complete cds. Corynebacterium
55,675 31-Jul-99 diphtheriae GB_EST23: AI096171 554 AI096171 28
EcoRI Rice Etiolated Leaf cDNA Library Oryza sativa cDNA clone
RZ513, Oryza sativa 38,536 19-Aug-98 mRNA sequence. rxa00326 603
GB_PH: MYP4CG 11624 X51522 Bacteriophage P4 complete DNA genome.
Bacteriophage P4 40,577 17-Feb-97 GB_PH: MYP4ALPH 3063 X05623
Bacteriophage P4 alpha gene and cis replication region crr.
Bacteriophage P4 38,64 12-Sep-93 GB_IN1: CEF22B3 30480 Z68336
Caenorhabditis elegans cosmid F22B3, complete sequence.
Caenorhabditis elegans 39,012 2-Sep-99 rxa00334 459 GB_BA1: CGGLNA
3686 Y13221 Corynebacterium glutamicum glnA gene. Corynebacterium
37,64 28-Aug-97 glutamicum GB_GSS10: AQ248516 259 AQ248516
T5J22-Sp6 TAMU Arabidopsis thaliana genomic clone T5J22, genomic
Arabidopsis thaliana 38,525 06-OCT-1998 survey sequence. GB_BA1:
CGGLNA 3686 Y13221 Corynebacterium glutamicum glnA gene.
Corynebacterium 40,487 28-Aug-97 glutamicum rxa00336 594 GB_BA1:
CGGLNA 3686 Y13221 Corynebacterium glutamicum glnA gene.
Corynebacterium 34,797 28-Aug-97 glutamicum GB_OV: XLFIMB1GN 7026
X95549 X. laevis FIM-B.1 gene. Xenopus laevis 33,217 13-Feb-97
GB_BA1: CGGLNA 3686 Y13221 Corynebacterium glutamicum glnA gene.
Corynebacterium 37,371 28-Aug-97 glutamicum rxa00337 1173 GB_BA1:
CGU43536 3464 U43536 Corynebacterium glutamicum heat shock,
ATP-binding protein (clpB) gene, Corynebacterium 36,406 13-MAR-1997
complete cds. glutamicum GB_BA1: CGAJ4934 1160 AJ004934
Corynebacterium glutamicum dapD gene, complete CDS. Corynebacterium
39,734 17-Jun-98 glutamicum GB_EST37: AI944838 396 AI944838
bs06a08.y1 Drosophila melanogaster adult testis library Drosophila
melanogaster Drosophila melanogaster 37,626 17-Aug-99 cDNA clone
bs06a08 5', mRNA sequence. rxa00338 1263 GB_BA1: BLTRP 7725 X04960
Brevibacterium lactofermentum tryptophan operon. Corynebacterium
39,79 10-Feb-99 glutamicum GB_PAT: E01688 7725 E01688 Genomic DNA
of trp operon of prepibacterium latophelmentamn. unidentified
39,871 29-Sep-97 GB_PAT: E01375 7726 E01375 DNA sequence of
tryptophan operon. Corynebacterium 39,871 29-Sep-97 glutamicum
rxa00339 840 GB_VI: OPU75930 131993 U75930 Orgyia pseudotsugata
nuclear polyhedrosis virus complete genome. Orgyia pseudotsugata
38,264 06-MAR-1998 nuclear polyhedrosis virus GB_VI: OPU75930
131993 U75930 Orgyia pseudotsugata nuclear polyhedrosis virus
complete genome. Orgyia pseudotsugata 38,62 06-MAR-1998 nuclear
polyhedrosis virus GB_HTG3: AC008340 126593 AC008340 Drosophila
melanogaster chromosome 2 clone BACR07J20 (D918) RPCI-98 07.J.20
Drosophila melanogaster 38,193 6-Aug-99 map 42D-42E strain y; cn bw
Sp, *** SEQUENCING IN PROGRESS ***, 92 unordered pieces. rxa00342
552 GB_EST34: AI794353 636 AI794353 fc43d12.y1 Zebrafish WashU
MPIMG EST Danio rerio cDNA 5' similar to Danio rerio 40,283
2-Jul-99 TR: Q62868 Q62868 ROK-ALPHA.;, mRNA sequence. GB_PR2:
U73635 33676 U73635 Human Chromosome 11 Cosmid cSRL156b6, complete
sequence. Homo sapiens 39,366 25-Jul-97 GB_PR2: U73635 33676 U73635
Human Chromosome 11 Cosmid cSRL156b6, complete sequence. Homo
sapiens 37,97 25-Jul-97 rxa00344 1002 GB_HTG2: HS312E8 33595
AL032819 Homo sapiens chromosome 16 clone LA16-312E8, ***
SEQUENCING IN Homo sapiens 40,415 03-DEC-1999 PROGRESS ***, in
unordered pieces. GB_HTG2: HS312E8 33595 AL032819 Homo sapiens
chromosome 16 clone
LA16-312E8, *** SEQUENCING IN Homo sapiens 40,415 03-DEC-1999
PROGRESS ***, in unordered pieces. GB_OM: BOVINOPHOS 1573 M55916
Bovine inositol polyphosphate 1-phosphatase (inositol polyphosphate
1-phosphatase Bos taurus 38,42 27-Apr-93 gene) mRNA, complete cds.
rxa00349 1590 GB_PR3: HS353E16 189765 AL031591 Human DNA sequence
from clone 353E16 on chromosome 22q11.22-12.3, Homo sapiens 34,766
23-Nov-99 complete sequence. GB_HTG2: AC005059 170128 AC005059 Homo
sapiens clone RG074A24, *** SEQUENCING IN PROGRESS ***, 25 Homo
sapiens 37,011 13-MAR-1999 unordered pieces. GB_HTG2: AC005059
170128 AC005059 Homo sapiens clone RG074A24, *** SEQUENCING IN
PROGRESS ***, 25 Homo sapiens 37,011 13-MAR-1999 unordered pieces.
rxa00353 816 GB_BA1: D87976 2352 D87976 Brevibacterium
lactofermentum DNA for D-2-hydroxyisocaproate dehydrogenase
Corynebacterium 39,29 7-Feb-99 (ddh), complete cds. glutamicum
GB_BA1: CGDDH 1829 Y00151 Corynebacterium glutamicum ddh gene for
meso-diaminopimelate D-dehydrogenase Corynebacterium 39,342
12-Sep-93 (EC 1.4.1.16). glutamicum GB_BA1: CGDDH 1829 Y00151
Corynebacterium glutamicum ddh gene for meso-diaminopimelate
D-dehydrogenase Corynebacterium 38,624 12-Sep-93 (EC 1.4.1.16).
glutamicum rxa00355 1143 GB_BA1: CGDDH 1829 Y00151 Corynebacterium
glutamicum ddh gene for meso-diaminopimelate D-dehydrogenase
Corynebacterium 100 12-Sep-93 (EC 1.4.1.16). glutamicum GB_BA1:
D87976 2352 D87976 Brevibacterium lactofermentum DNA for
D-2-hydroxyisocaproate dehydrogenase Corynebacterium 98,411
7-Feb-99 (ddh), complete cds. glutamicum GB_PAT: E14511 1034 E14511
DNA encoding Brevibacterium diaminopimelic acid dehydrogenase.
Corynebacterium 100 28-Jul-99 glutamicum rxa00362 1470 GB_HTG4:
AC009043 170748 AC009043 Homo sapiens chromosome 16 clone
RPCI-11_184F14, *** SEQUENCING IN Homo sapiens 37,337 31-OCT-1999
PROGRESS ***, 122 unordered pieces. GB_HTG4: AC009043 170748
AC009043 Homo sapiens chromosome 16 clone RPCI-11_184F14, ***
SEQUENCING IN Homo sapiens 37,337 31-OCT-1999 PROGRESS ***, 122
unordered pieces. GB_PR4: HSZO2TJP09 811 AF177521 Homo sapiens
tight junction protein ZO-2 (TJP2) gene, exons 8 and 9. Homo
sapiens 40,758 28-Sep-99 rxa00373 439 GB_PAT: AR004983 2277
AR004983 Sequence 5 from patent U.S. Pat. No. 5747317. Unknown.
41,638 04-DEC-1998 GB_EST37: AI967505 380 AI967505
Ljirnpest03-215-c10 Ljirnp Lambda HybriZap two-hybrid library Lotus
japonicus Lotus japonicus 45,882 24-Aug-99 cDNA clone LP215-0.3-c10
5' similar to 60S ribosomal protein L39, mRNA sequence. GB_EST27:
AI399460 670 AI399460 NCSP4F6T7 Subtracted Perithecial Neurospora
crassa cDNA clone SP4F6 3', Neurospora crassa 38,571 8-Feb-99 mRNA
sequence. rxa00375 624 GB_IN2: AC004445 61852 AC004445 Drosophila
melanogaster DNA sequence (P1 DS00445 (D93)), complete sequence.
Drosophila melanogaster 37,236 01-MAY-1998 GB_HTG6: AC011694 160557
AC011694 Homo sapiens clone RP11-19D19, *** SEQUENCING IN PROGRESS
***, 33 Homo sapiens 34,087 03-DEC-1999 unordered pieces. GB_HTG6:
AC011694 160557 AC011694 Homo sapiens clone RP11-19D19, ***
SEQUENCING IN PROGRESS ***, 33 Homo sapiens 40,523 03-DEC-1999
unordered pieces. rxa00380 744 GB_BA1: COXHSPAB 2302 M20482 C.
burnetii heat shock operon encoding two heat shock proteins (htpA
and htpB), Coxiella burnetii 37,788 26-Apr-93 complete cds. GB_RO:
CBGPIMR 1735 Z37977 C. barabensis (griseus) mRNA for glucose
phosphate isomerase. Cricetulus griseus 37,823 14-Sep-95 GB_GSS10:
AQ172617 505 AQ172617 HS_3197_A2_G09_T7 CIT Approved Human Genomic
Sperm Library D Homo Homo sapiens 37,58 17-OCT-1998 sapiens genomic
clone Plate = 3197 Col = 18 Row = M, genomic survey sequence.
rxa00387 978 GB_BA1: MTY25D10 40838 Z95558 Mycobacterium
tuberculosis H37Rv complete genome; segment 28/162. Mycobacterium
60,477 17-Jun-98 tuberculosis GB_BA1: MSGY224 40051 AD000004
Mycobacterium tuberculosis sequence from clone y224. Mycobacterium
60,27 03-DEC-1998 tuberculosis GB_BA1: U00018 42991 U00018
Mycobacterium leprae cosmid B2168. Mycobacterium leprae 37,913
01-MAR-1994 rxa00390 528 GB_IN1: DMU29153 8230 U29153 Drosophila
melanogaster nudel (ndl) mRNA, complete cds. Drosophila
melanogaster 36,19 08-DEC-1995 GB_IN1: DMU29153 8230 U29153
Drosophila melanogaster nudel (ndl) mRNA, complete cds. Drosophila
melanogaster 37,202 08-DEC-1995 rxa00392 987 GB_IN2: AE001274
268984 AE001274 Leishmania major chromosome 1, complete sequence.
Leishmania major 37,885 24-MAR-1999 GB_EST11: AA270543 516 AA270543
va68h06.r1 Soares mouse 3NME12 5 Mus musculus cDNA clone IMAGE:
736571 Mus musculus 40,546 26-MAR-1997 5', mRNA sequence. GB_IN2:
AE001274 268984 AE001274 Leishmania major chromosome 1, complete
sequence. Leishmania major 36,103 24-MAR-1999 rxa00394 456 GB_GSS9:
AQ158990 728 AQ158990 nbxb0012L11r CUGI Rice BAC Library Oryza
sativa genomic clone nbxb0012L11r, Oryza sativa 41,463 12-Sep-98
genomic survey sequence. GB_GSS12: AQ342952 761 AQ342952
RPCI11-122O15.TV RPCI-11 Homo sapiens genomic clone RPCI-11-122O15,
Homo sapiens 37,556 07-MAY-1999 genomic survey sequence. GB_GSS9:
AQ158990 728 AQ158990 nbxb0012L11r CUGI Rice BAC Library Oryza
sativa genomic clone nbxb0012L11r, Oryza sativa 37,923 12-Sep-98
genomic survey sequence. rxa00395 423 GB_PR2: HS1052M9 134245
AL022718 Human DNA sequence from clone 1052M9 on chromosome Xq25.
Contains the Homo sapiens 43,564 23-Nov-99 SH2D1A gene for SH2
domain protein 1A, Duncan's disease (lymphoproliferative syndrome)
(DSHP), part of a 60S Acidic Ribosomal protein 1 (RPLP1) LIKE gene
and part of a mouse DOC4 LIKE gene. Contains ESTs and GSSs,
complete sequence. GB_BA2: RCPHSYNG 45959 Z11165 R. capsulatus
complete photosynthesis gene cluster. Rhadobacter capsulatus 36,930
2-Sep-99 GB_PR2: HS1052M9 134245 AL022718 Human DNA sequence from
clone 1052M9 on chromosome Xq25. Contains the Homo sapiens 33,981
23-Nov-99 SH2D1A gene for SH2 domain protein 1A, Duncan's disease
(lymphoproliferative syndrome) (DSHP), part of a 60S Acidic
Ribosomal protein 1 (RPLP1) LIKE gene and part of a mouse DOC4 LIKE
gene. Contains ESTs and GSSs, complete sequence. rxa00396 594
GB_PL2: AC002311 85855 AC002311 Arabidopsis thaliana chromosome I
BAC T26J12 genomic sequence, complete Arabidopsia thaliana 38,957
4-Feb-98 sequence. GB_PL2: AC002311 85855 AC002311 Arabidopsis
thaliana chromosome I BAC T26J12 genomic sequence, complete
Arabidopsis thaliana 36,3 4-Feb-98 sequence. rxa00397 924 GB_PL1:
HASMT 27694 D31785 Hansenula wingei mitochondrial DNA, complete
sequence. Mitochondrion Pichia 33,985 10-Jun-99 canadensis GB_PL1:
HASMT 27694 D31785 Hansenula wingel mitochondrial DNA. complete
sequence. Mitochondrion Pichia 33,775 10-Jun-99 canadensis rxa00398
873 GB_HTG1: CNS01DRT 222150 AL118557 Homo sapiens chromosome 14
clone R-1033H12, *** SEQUENCING IN Homo sapiens 35,417 25-Sep-99
PROGRESS ***, in ordered pieces. GB_HTG1: CNS01DRT 222150 AL118557
Homo sapiens chromosome 14 clone R-1033H12, *** SEQUENCING IN Homo
sapiens 35,417 25-Sep-99 PROGRESS ***, in ordered pieces. GB_HTG1:
CNS01DRT 222150 AL118557 Homo sapiens chromosome 14 clone
R-1033H12, *** SEQUENCING IN Homo sapiens 38,005 25-Sep-99 PROGRESS
***, in ordered pieces. rxa00399 438 GB_IN1: CELC32B5 42545 U80843
Caenorhabditis elegans cosmid C32B5. Caenorhabditis elegans 36,468
05-DEC-1996 GB_IN1: CELC32B5 42545 U80843 Caenorhabditis elegans
cosmid C32B5. Caenorhabditis elegans 40 05-DEC-1996 rxa00408 570
GB_PR4: AC005940 158414 AC005940 Homo sapiens chromosome 17, clone
hRPK. 167_N_20, complete sequence. Homo sapiens 35,219 18-MAR-1999
GB_PR1: HSSERCA11 3050 Y15726 Homo sapiens SERCA3 gene, exons
11-14. Homo sapiens 35,036 30-Jun-98 GB_PR4: AC005940 158414
AC005940 Homo sapiens chromosome 17, clone hRPK. 167_N_20, complete
sequence. Homo sapiens 36,926 18-MAR-1999 rxa00409 1536 GB_PR1:
HSSERCA11 3050 Y15726 Homo sapiens SERCA3 gene, exons 11-14. Homo
sapiens 38,555 30-Jun-98 GB_PR4: AC005940 158414 AC005940 Homo
sapiens chromosome 17, clone hRPK. 167_N_20, complete sequence.
Homo sapiens 36,37 18-MAR-1999 GB_PR3: HS591B8 142552 AL035410
Human DNA sequence from clone 591B8 on chromosome 1p13.1. complete
sequence. Homo sapiens 35,891 23-Nov-99 rxa00411 798 GB_BA1:
AP000003 233000 AP000003 Pyrococcus horikoshii OT3 genomic DNA,
544001-777000 nt. position (3/7). Pyrococcus horikoshii 36,849
8-Feb-99 GB_PL2: F25A4 115721 AC008263 Arabidopsis thaliana
chromosome 1 BAC F25A4 sequence, complete sequence. Arabidopsis
thaliana 37,628 15-Sep-99 GB_PR3: HS413H6 142599 AL022724 Human DNA
sequence from clone 413H6 on chromosome 6p22.3-24.3. Contains Homo
sapiens 36,755 23-Nov-99 a hamster Androgen-dependent Expressed
Protein like protein gene, ESTs and GSSs, complete sequence.
rxa00416 1673 GB_EST8: C10137 360 C10137 C10137 Yuji Kohara
unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis
elegans 35,574 18-OCT-1999 Caenorhabditis elegans cDNA clone
yk188a1 5', mRNA sequence. GB_EST36: AV186952 376 AV186952 AV186952
Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryo
Caenorhabditis elegans 36,702 22-Jul-99 Caenorhabditis elegans cDNA
clone yk506a5 5', mRNA sequence. GB_EST16: C48235 383 C48235 C48235
Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryo
Caenorhabdilis elegans 42,44 18-OCT-1999 Caenorhabditis elegans
cDNA clone yk459h10 5', mRNA sequence. rxa00422 1017 GB_BA1:
MTCY227 35946 Z77724 Mycobacterium tuberculosis H37RV complete
genome; segment 114/162. Mycobacterium 39,822 17-Jun-98
tuberculosis GB_BA1: MTV023 47852 AL022022 Mycobacterium
tuberculosis H37Rv complete genome; segment 148/162. Mycobacterium
39,841 17-Jun-98 tuberculosis GB_PR3: AC003091 137817 AC003091
Human BAC clone RG326G04 from 7p21, complete sequence. Homo sapiens
36,653 6-Nov-97 rxa00423 576 GB_BA1: AP000063 185300 AP000063
Aeropyrum pernix genomic DNA, section 6/7. Aeropyrum pernix 38,908
22-Jun-99 GB_IN1: LDHSP100 7726 Z94053 L. donovani hsp 100 gene.
Leishmania donovani 39,646 28-Apr-97 GB_GSS11: AQ274393 572
AQ274393 nbxb0035G12r CUGI Rice BAC Library Oryza sativa genomic
clone nbxb0035G12r, Oryza sativa 35,714 3-Nov-98 genomic survey
sequence. rxa00424 594 GB_BA1: AP000063 185300 AP000063 Aeropyrum
pernix genomic DNA, section 6/7. Aeropyrum pernix 38,225 22-Jun-99
GB_BA1: AP000063 185300 AP000063 Aeropyrum pernix genomic DNA,
section 6/7. Aeropyrum pernix 36,735 22-Jun-99 GB_IN1: LDHSP100
7726 Z94053 L. donovani hsp100 gene. Leishmania donovani 35,125
28-Apr-97 rxa00425 348 GB_EST30: AV021214 281 AV021214 AV021214 Mus
musculus 18-day embryo C57BL/6J Mus musculus cDNA clone Mus
musculus 35,849 28-Aug-99 1190021P08, mRNA sequence. GB_HTG3:
AC009278 164119 AC009278 Homo sapiens clone 44_J_4, *** SEQUENCING
IN PROGRESS ***, Homo sapiens 36,705 12-Aug-99 14 unordered pieces.
GB_HTG3: AC009278 164119 AC009278 Homo sapiens clone 44_J_4, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 36,705 12-Aug-99 14
unordered pieces. rxa00428 756 GB_BA2: AF127082 10847 AF127082
Myxococcus xanthus ATP-dependent protease proteolytic subunit ClpP
(clpP), Myxococcus xanthus 40,995 18-MAY-1999 ATP-dependent
protease ATPase subunit ClpX (clpX), prolyl endopeptidase precursor
Pep (pep), ATP-dependent protease LonV(lonV), oligopeptide permease
homolog OppA (oppA), oligopeptide permease homolog OppB (oppB), and
oligopeptide permease homolog OppC (oppC) genes, complete cds.
GB_PL1: AB017080 653 AB017080 Porphyra sp. DNA, internal
transcribed spacer 1 (ITS1). Porphyra sp. 38,491 10-Sep-99
GB_EST27: AI442425 541 AI442425 sa26g05.y1 Gm-c1004 Glycine max
cDNA clone GENOME SYSTEMS CLONE ID: Glycine max 40 01-DEC-1999
Gm-c1004-465 5' similar to SW: NDC1_RABIT Q28615 RENAL
SODIUM/DICARBOXYLATE COTRANSPORTER;, mRNA sequence. rxa00429 525
GB_EST3: R33129 440 R33129 yh81c08.s1 Soares placenta Nb2HP Homo
sapiens cDNA clone IMAGE: 136142 Homo sapiens 37,216 28-Apr-95 3'
similar to gb: X53742_rna1 FIBULIN 1, ISOFORM B PRECURSOR (HUMAN);,
mRNA sequence. GB_PH: AF115103 40739 AF115103 Streptococcus
thermophilus bacteriophage Sfi21, complete genome. Streptococcus
36,069 18-Jul-99 thermophilus bacteriophage Sfi21 GB_PH: AF115102
37370 AF115102 Streptococcus thermophilus bacteriophage Sfi19,
complete genome. Streptococcus 36,26 18-Jul-99 thermophilus
bacteriophage Sfi19 rxa00430 534 GB_BA1: MSGY126 37164 AD000012
Mycobacterium tuberculosis uence from clone y126. Mycobacterium
55,491 10-DEC-1996 tuberculosis GB_BA1: MTY13D12 37085 Z80343
Mycobacterium tuberculosis Rv complete genome; segment 156/162.
Mycobacterium 55,491 17-Jun-98 tuberculosis GB_BA1: MSGB971CS 37566
L78821 Mycobacterium leprae mid B971 DNA sequence. Mycobacterium
leprae 36,905 15-Jun-96 rxa00433 648 GB_PR2: AP000073 100000
AP000073 Homo sapiens genomic DNA, chromosome 8p11.2, senescence
gene region, section Homo sapiens 38,043 20-Nov-99 9/19, complete
sequence. GB_IN1: CELF29G9 42751 AF016440 Caenorhabditis elegans
cosmid F29G9. Caenorhabditis elegans 35,474 7-Aug-97 GB_BA1:
MSGY414A 40121 AD000007 Mycobacterium tuberculosis uence from clone
y414a. Mycobacterium 36,809 03-DEC-1996
tuberculosis rxa00447 rxa00451 615 GB_EST26: AI389267 643 AI389267
GH20396.5prime GH Drosophila melanogaster head pOT2 Drosophila
Drosophila melanogaster 41,085 28-Jan-99 melanogaster cDNA clone
GH20396 5prime, mRNA sequence. GB_EST37: AI945493 574 AI945493
bs13e05.y1 Drosophila melanogaster adult testis library Drosophila
Drosophila melanogaster 44,04 17-Aug-99 melanogaster cDNA clone
bs13e05 5', mRNA sequence. GB_GSS11: AQ288118 630 AQ288118
nbxb0032l18r CUGI Rice BAC Library Oryza sativa genomic clone
nbxb0032l18r, Oryza sativa 37,885 03-DEC-1998 genomic survey
sequence. rxa00455 873 GB_IN1: DMOVO 6655 X59772 D. melanogaster
ovo gene required for female germ line development. Drosophila
melanogaster 35,104 24-Feb-99 GB_EST14: AA390588 513 AA390588
LD09657.5prime LD Drosophila melanogaster embryo BlueScript
Drosophila Drosophila melanogaster 39,759 28-Nov-98 melanogaster
cDNA clone LD09657 5prime, mRNA sequence. GB_EST19: AA801874 621
AA801874 GM03519.5prime GM Drosophila melanogaster ovary BlueScript
Drosophila Drosophila melanogaster 35,437 25-Nov-98 melanogaster
cDNA clone GM03519 5prime similar to U11383: ovo FBgn0003028 PID:
g520527 SWISS-PROT: P51521, mRNA sequence. rxa00457 1203 GB_GSS8:
AQ000125 398 AQ000125 CIT-HSP-2282P3.TF CIT-HSP Homo sapiens
genomic clone 2282P3, Homo sapiens 41,73 26-Jun-98 genomic survey
sequence. GB_IN1: DROADDLIKE 4209 L14330 Drosophila melanogaster
adducin-like protein, complete cds. Drosophila melanogaster 37,795
11-Jun-93 GB_IN1: DROHTSC 3922 L05016 Drosophila melanogaster hu-li
tal shao (hts) mRNA, complete cds. Drosophila melanogaster 37,081
26-Apr-93 rxa00462 1503 GB_HTG3: AC009210 103814 AC009210
Drosophila melanogaster chromosome 2 clone BACR01I06 (D1054)
RPCI-98 01.I.6 Drosophila melanogaster 33,356 20-Aug-99 map 55D-55D
strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 86 unordered
pieces. GB_HTG3: AC009210 103814 AC009210 Drosophila melanogaster
chromosome 2 clone BACR01I06 (D1054) RPCI-98 01.I.6 Drosophila
melanogaster 33,356 20-Aug-99 map 55D-55D strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 86 unordered pieces. GB_BA1: SCE9 37730
AL049841 Streptomyces coelicolor mid E9. Streptomyces coelicolor
37,308 19-MAY-1999 rxa00463 945 GB_BA2: AF052652 2096 AF052652
Corynebacterium glutamicum oserine O-acetyltransferase (metA) gene,
Corynebacterium 99,481 19-MAR-1998 complete cds. glutamicum
GB_GSS12: AQ407770 500 AQ407770 HS_5069_B1_F03_T7A RPCI-11 Human
Male BAC Library Homo sapiens Homo sapiens 40,081 17-MAR-1999
genomic clone Plate = 645 Col = 5 Row = L, genomic survey sequence.
GB_GSS15: AQ596209 358 AQ596209 HS_5482_A2_H10_SP6E RPCI-11 Human
Male BAC Library Homo sapiens Homo sapiens 40 8-Jun-99 genomic
clone Plate = 1058 Col = 20 Row = O, genomic survey sequence.
rxa00468 942 GB_EST32: AI763195 341 AI763196 wi65h04.x1
NCI_CGAP_Kid12 Homo sapiens cDNA clone IMAGE: 2398231 3', Homo
sapiens 38,824 24-Jun-99 mRNA sequence. GB_EST17: AA652964 329
AA652964 ns62e02.s1 NCI_CGAP_Pr22 Homo sapiens cDNA clone IMAGE:
1188218 3', Homo sapiens 41,104 13-Nov-97 mRNA sequence. GB_EST20:
AA864303 411 AA864303 oh54d02.s1 NCI_CGAP_GC4 Homo sapiens cDNA
clone IMAGE: 1470435 3', Homo sapiens 41,422 13-MAY-1998 mRNA
sequence. rxa00469 1299 GB_PR4: AC005988 173126 AC005988 Homo
sapiens chromosome 17, clone hRPK.299_G_24, complete sequence. Homo
sapiens 34,699 15-Jan-99 GB_PR4: AC005988 173126 AC005988 Homo
sapiens chromosome 17, clone hRPK.299_G_24, complete sequence. Homo
sapiens 35,725 15-Jan-99 GB_HTG3: AC009116 186292 AC009116 Homo
sapiens chromosome 18 clone RPCI-11_47703, *** SEQUENCING IN Homo
sapiens 36,222 3-Aug-99 PROGRESS ***, 47. unordered pieces.
rxa00472 942 GB_HTG3: AC007882 214882 AC007882 Homo sapiens clone
NH0499D05, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,245
8-Sep-99 2 unordered pieces. GB_HTG3: AC007882 214882 AC007882 Homo
sapiens clone NH0499D05, *** SEQUENCING IN PROGRESS ***, Homo
sapiens 38,245 8-Sep-99 2 unordered pieces. GB_PR2: HUAC002038
161973 AC002038 Homo sapiens chromosome 2 clone 101B6 map 2p11,
complete sequence. Homo sapiens 37,961 30-Jun-97 rxa00473 912
GB_HTG3: AC011445 144370 AC011445 Homo sapiens chromosome 19 clone
CIT-HSPC_246B18, *** SEQUENCING IN Homo sapiens 38,47 07-OCT-1999
PROGRESS ***, 31 unordered pieces. GB_HTG3: AC011445 144370
AC011445 Homo sapiens chromosome 19 clone CIT-HSPC_246B18, ***
SEQUENCING IN Homo sapiens 38,47 07-OCT-1999 PROGRESS ***, 31
unordered pieces. GB_RO: AB026437 2097 AB026437 Mus musculus DNA,
5' flanking region of interleukin 12 receptor beta 1. Mus musculus
40 02-OCT-1999 rxa00474 1701 GB_GSS10: AQ223838 543 AQ223838
HS_2218_A1_H03_MR CIT Approved Human Genomic Sperm Library D Homo
Homo sapiens 40,189 20-Sep-98 sapiens genomic clone Plate = 2218
Col = 5 Row = O, genomic survey sequence. GB_GSS10: AQ223838 543
AQ223838 HS_2218_A1_H03_MR CIT Approved Human Genomic Sperm Library
D Homo Homo sapiens 37,944 20-Sep-98 sapiens genomic clone Plate =
2218 Col = 5 Row = O, genomic survey sequence. rxa00475 783 GB_PL2:
GMAKHSDH2 10535 AF049708 Glycine max aspartokinase-homoserine
dehydrogenase (AK-HSDH) gene, partial cds. Glycine max 36,446
7-Jul-99 GB_EST14: AA386651 351 AA386651 vb54b04.r1 Ko mouse embryo
11 5dpc Mus musculus cDNA clone IMAGE: 760783 Mus musculus 41,311
23-Apr-97 5', mRNA sequence. GB_EST14: AA386603 498 AA386603
vb53c02.r1 Ko mouse embryo 11 5dpc Mus musculus cDNA clone IMAGE:
760706 Mus musculus 40,644 23-Apr-97 5' similar to TR: G56689
G56689 DIMETHYLGLYCINE DEHYDROGENASE.;, mRNA sequence. rxa00476 984
GB_GSS5: AQ770769 554 AQ770769 HS_5357_B2_H01_T7A RPCI-11 Human
Male BAC Library Homo sapiens Homo sapiens 35,56 28-Jul-99 genomic
clone Plate = 933 Col = 2 Row = P, genomic survey sequence. GB_IN1:
CEM162 39977 Z82278 Caenorhabditis elegans cosmid M162, complete
sequence. Caenorhabditis elegans 34,224 19-Nov-99 GB_IN1: CEM162
39977 Z82278 Caenorhabditis elegans cosmid M162, complete sequence.
Caenorhabditis elegans 33,777 19-Nov-99 rxa00481 708 GB_PR4:
AC005013 195910 AC005013 Homo sapiens BAC clone GS165L15 from 7p15,
complete sequence. Homo sapiens 35,755 28-Nov-98 GB_HTG1: PFMAL4P4
224448 AL035477 Plasmodium falciparum chromosome 4 strain 3D7, ***
SEQUENCING IN Plasmodium falciparum 37,213 11-Aug-99 PROGRESS ***,
in unordered pieces. GB_HTG1: PFMAL4P4 224448 AL035477 Plasmodium
falciparum chromosome 4 strain 3D7, *** SEQUENCING IN Plasmodium
falciparum 37,213 11-Aug-99 PROGRESS ***, in unordered pieces.
rxa00485 2418 GB_EST30: AV017239 238 AV017239 AV017239 Mus musculus
18-day embryo C57BL/6J Mus musculus cDNA Mus musculus 39,916
28-Aug-99 clone 1110069G23, mRNA sequence. GB_EST33: AV093875 254
AV093875 AV093875 Mus musculus C57BL/6J ES Cell Mus musculus cDNA
clone Mus musculus 38,189 22-Nov-99 2400006D21, mRNA sequence.
GB_EST33: AV084536 287 AV084536 AV084536 Mus musculus tongue
C57BL/6J adult Mus musculus cDNA clone Mus musculus 37,282
25-Jun-99 2310007K01, mRNA sequence. rxa00486 1032 GB_RO: MUSP3VPR2
1089 AF098867 Mus sp. 129SV V3/V1b vasopressin receptor gene, exon
2 and complete cds. Mus musculus 38,163 28-Apr-99 GB_GSS9: AQ166448
407 AQ166448 HS_3137_B2_A06_MR CIT Approved Human Genomic Sperm
Library D Homo Homo sapiens 40,25 16-OCT-1998 sapiens genomic clone
Plate = 3137 Col = 12 Row = B, genomic survey sequence. GB_GSS15:
AQ614261 505 AQ614261 HS_5123_B1_F11_SP6E RPCI-11 Human Male BAC
Library Homo sapiens Homo sapiens 37,905 15-Jun-99 genomic clone
Plate = 699 Col = 21 Row = L, genomic survey sequence. rxa00490
1026 GB_EST15: AA463205 282 AA463205 zx71c06.s1
Soares_total_fetus_Nb2HF8_9w_Homo sapiens cDNA clone IMAGE: Homo
sapiens 39,502 10-Jun-97 796906 3', mRNA sequence. GB_BA1: SLLINC
36270 X79146 S. lincolnensis (78-11) Lincomycin production genes.
Streptomyces lincolnensis 37,278 15-MAY-1996 GB_GSS3: B10984 646
B10984 F22I8-Sp6 IGF Arabidopsis thaliana genomic clone F22I8,
genomic survey sequence. Arabidopsis thaliana 39,205 14-MAY-1997
rxa00491 543 GB_HTG1: CEY87G2 330612 AL022597 Caenorhabditis
elegans chromosome I clone Y87G2, *** SEQUENCING IN Caenorhabditis
elegans 37,405 26-OCT-1999 PROGRESS ***, in unordered pieces.
GB_HTG1: CEY87G2 330612 AL022597 Caenorhabditis elegans chromosome
I clone Y87G2, *** SEQUENCING IN Caenorhabditis elegans 37,405
26-OCT-1999 PROGRESS ***, in unordered pieces. GB_HTG1: CEY6B3
253516 Z92865 Caenorhabditis elegans chromosome I clone Y6B3, ***
SEQUENCING IN Caenorhabditis elegans 38,213 30-Jul-98 PROGRESS ***,
in unordered pieces. rxa00493 1737 GB_BA1: SC6G4 41055 AL031317
Streptomyces coelicolor cosmid 6G4. Streptomyces coelicolor 61,649
20-Aug-98 GB_BA2: U00015 42325 U00015 Mycobacterium leprae cosmid
B1620. Mycobacterium leprae 38,567 01-MAR-1994 GB_BA1: U00020 36947
U00020 Mycobacterium leprae cosmid B229. Mycobacterium leprae
38,567 01-MAR-1994 rxa00496 1149 GB_VI: TVRNAP 6404 X68414 Toscana
Virus genomic RNA for RNA-dependent RNA polymerase. Toscana virus
35,428 27-OCT-1992 GB_IN2: DMU09808 9239 U09808 Drosophila
melanogaster twisted gastrulation (tsg) and serine protease (gd)
genes, Drosophila melanogaster 36,837 25-Jun-98 complete cds.
GB_IN2: DMU09808 9239 U09808 Drosophila melanogaster twisted
gastrulation (tsg) and serine protease (gd) genes, Drosophila
melanogaster 37,782 25-Jun-98 complete cds. rxa00504 543 GB_BA1:
MTCY159 33818 Z83863 Mycobacterium tuberculosis H37Rv complete
genome; segment 111/162. Mycobacterium 36,961 17-Jun-98
tuberculosis GB_PR1: HUMHM145 2214 D10925 Human mRNA for HM145.
Home sapiens 38,066 3-Feb-99 GB_EST14: AA415083 332 AA415083 Mg0017
RCW Lambda Zap Express Library Pyricularia grisea cDNA clone
Pyricularia grisea 40,181 09-DEC-1999 RCW17 5', mRNA sequence.
rxa00505 618 GB_PAT: I92047 551 I92047 Sequence 14 from patent U.S.
Pat. No. 5726299. Unknown. 46,25 01-DEC-1998 GB_PAT: I78759 549
I78759 Sequence 15 from patent U.S. Pat. No. 5693781. Unknown.
44,813 3-Apr-98 GB_PAT: I92048 549 I92048 Sequence 15 from patent
U.S. Pat. No. 5726299. Unknown. 44,813 01-DEC-1998 rxa00507 978
GB_PR2: HS1063B2 114596 AL035683 Human DNA sequence from clone
1063B2 on chromosome 20q13.1-13.2. Contains Homo sapiens 36,449
23-Nov-99 the 3' part of the gene for
Beta-1,4-galactosyltransferase, ESTs, STSs and GSSs, complete
sequence. GB_HTG2: AC007225 218892 AC007225 Homo sapiens chromosome
16 clone 480G7, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,646
6-Apr-99 38 unordered pieces. GB_HTG2: AC007225 218892 AC007225
Homo sapiens chromosome 16 clone 480G7, *** SEQUENCING IN PROGRESS
***, Homo sapiens 36,646 6-Apr-99 38 unordered pieces. rxa00510
1632 GB_GSS4: AQ707590 499 AQ707590 HS_5560_B1_H02_SP6E RPCI-11
Human Male BAC Library Homo sapiens Homo sapiens 37,275 7-Jul-99
genomic clone Plate = 1136 Col = 3 Row = P, genomic survey
sequence. GB_GSS4: AQ707590 499 AQ707590 HS_5560_B1_H02_SP6E
RPCI-11 Human Male BAC Library Home sapiens Homo sapiens 37,275
7-Jul-99 genomic clone Plate = 1136 Col = 3 Row = P, genomic survey
sequence. rxa00515 825 GB_BA1: CGICD 3595 X71489 C. glutamicum icd
gene for monomeric isocitrate dehydrogenase. Corynebacterium 100
17-Feb-95 glutamicum GB_BA1: CGICD 3595 X71489 C. glutamicum icd
gene for monomeric isocitrate dehydrogenase. Corynebacterium 38,15
17-Feb-95 glutamicum GB_GSS13: AQ451896 509 AQ451896
HS_5184_B1_C03_SP6E RPCI-11 Human Male BAC Library Homo sapiens
Homo sapiens 36,638 21-Apr-99 genomic clone Plate = 760 Col = 5 Row
= F, genomic survey sequence. rxa00519 2337 GB_BA1: CGICD 3595
X71489 C. glutamicum icd gene for monomeric isocitrate
dehydrogenase. Corynebacterium 100 17-Feb-95 glutamicum GB_BA2:
AF127018 2560 AF127018 Streptomyces coelicolor isocitrate
dehydrogenase (idh) gene, idh-B allele, complete Streptomyces
coelicolor 66,667 1-Jun-99 cds. GB_BA1: AVIICD 3550 D73443
Azotobacter vinelandil icd gene for isocitrate dehydrogenase,
complete cds. Azotobacter vinelandil 63,652 4-Feb-99 rxa00527 1887
GB_PAT: I92049 2248 I92049 Sequence 16 from patent U.S. Pat. No.
5726299. Unknown. 39,25 01-DEC-1998 GB_PAT: I92053 2213 I92053
Sequence 20 from patent U.S. Pat. No. 5726299. Unknown. 70,635
01-DEC-1998 GB_BA1: MTCY98 31225 Z83860 Mycobacterium tuberculosis
H37Rv complete genome; segment 103/162. Mycobacterium 37,741
17-Jun-98 tuberculosis rxa00528 1212 GB_BA1: MSGY219 38721 AD000013
Mycobacterium tuberculosis sequence from clone y219. Mycobacterium
68,672 10-DEC-1996 tuberculosis GB_BA1: MTCY21D4 20760 Z80775
Mycobacterium tuberculosis H37Rv complete genome; segment 3/262.
Mycobacterium 39,762 24-Jun-99 tuberculosis GB_BA1: SCH24 41625
AL049826 Streptomyces coelicolor cosmid H24. Streptomyces
coelicolor 40,411 11-MAY-1999 rxa00529 666 GB_PR2: HSAC000109 41122
AC000109 Human Cosmid g0771a222 from 7q31.3, complete sequence.
Homo sapiens 37,462 11-Sep-97 GB_PR2: HSAC000110 45508 AC000110
Human Cosmid g0771a233, complete sequence. Homo sapiens 37,462
30-Jan-97 GB_PR2: HSAC000109 41122 AC000109 Human Cosmid g0771a222
from 7q31.3, complete sequence. Homo sapiens 39,724 11-Sep-97
rxa00530 1404 GB_PR3: HS435C23 151798 Z92844 Human DNA sequence
from PAC 435C23 on chromosome X. Contains ESTs. Homo sapiens 36,482
23-Nov-99
GB_PR3: HS435C23 151798 Z92844 Human DNA sequence from PAC 435C23
on chromosome X. Contains ESTs. Homo sapiens 37,918 23-Nov-99
GB_PL1: YSCADE3 4883 M12878 Saccharomyces cerevisiae
C-1-tetrahydrofolate synthase (ADE3) gene, complete cds.
Saccharomyces cerevisiae 37,034 11-MAY-1995 rxa00535 840 GB_BA1:
CGLEUA 3492 X70959 C. glutamicum gene leuA for isopropylmalate
synthase. Corynebacterium 100 10-Feb-99 glutamicum GB_BA1: CORASKD
2957 L16848 Corynebacterium flavum aspartokinase (ask), and
aspartate-semialdehyde Corynebacterium 43,75 11-Jun-93
dehydrogenase (asd) genes, complete cds. flavescens GB_GSS10:
AQ193141 515 AQ193141 HS_3060_B1_F11_MF CIT Approved Human Genomic
Sperm Library D Homo sapiens 44,773 4-Nov-98 Homo sapiens genomic
clone Plate = 3060 Col = 21 Row = L, genomic survey sequence.
rxa00540 366 GB_PAT: I92052 2115 I92052 Sequence 19 from patent
U.S. Pat. No. 5726299. Unknown. 74,795 01-DEC-1998 GB_HTG2:
AC008095 126322 AC008095 Drosophila melanogaster chromosome 2 clone
BACR11H16 (D932) RPCI-98 11.H.16 Drosophila melanogaster 41,899
2-Aug-99 map 52A-52A strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 95 unordered pieces. GB_HTG2: AC008095 126322 AC008095
Drosophila melanogaster chromosome 2 clone BACR11H16 (D932) RPCI-98
11.H.16 Drosophila melanogaster 41,899 2-Aug-99 map 52A-52A strain
y; cn bw sp, *** SEQUENCING IN PROGRESS***, 95 unordered pieces.
rxa00547 1521 GB_BA1: MSGY219 38721 AD000013 Mycobacterium
tuberculosis sequence from clone y219. Mycobacterium 36,91
10-DEC-1996 tuberculosis GB_BA1: MTCY21D4 20760 Z80775
Mycobacterium tuberculosis H37Rv complete genome; segment 3/262.
Mycobacterium 51,125 24-Jun-99 tuberculosis GB_EST27: AI415174 292
AI415174 mc05c02.x1 Soares mouse p3NMF19.5 Mus musculus cDNA clone
IMAGE: Mus musculus 39,384 9-Feb-99 338018 3', mRNA sequence.
rxa00549 1797 GB_PL2: ATAC007135 27313 AC007135 Arabidopsis
thaliana chromosome II BAC F9C22 genomic sequence, Arabidopsis
thaliana 35,584 26-MAY-1999 complete sequence. GB_PL2: ATAC006921
76042 AC006921 Arabidopsis thaliana chromosome II BAC F2H17 genomic
sequence, Arabidopsis thaliana 36,581 23-MAR-1999 complete
sequence. GB_PL2: ATAC007135 27313 AC007135 Arabidopsis thaliana
chromosome II BAC F9C22 genomic sequence, Arabidopsis thaliana
35,827 26-MAY-1999 complete sequence. rxa00550 rxa00552 1059
GB_BA1: D90742 19201 D90742 Escherichia coli genomic DNA.
(23.8-24.2 min). Escherichia coli 46,072 7-Feb-99 GB_BA1: ECHTRB
3129 X61000 E. coli K12 HtrB gene. Escherichia coli 39,164
30-Jun-93 GB_BA2: AE000207 11148 AE000207 Escherichia coli K-12
MG1655 section 97 of 400 of the complete genome. Escherichia coli
46,072 12-Nov-98 rxa00553 444 GB_EST18: AB009093 479 AB009093
AB009093 Chlamydomonas W80 lambda ZAP II Chlamydomonas sp. cDNA
similar Chlamydomonas sp. 41,808 05-DEC-1997 to photosystem II 10
kDa protein, mRNA sequence. GB_EST30: AI640954 641 AI640954
AEMTAP02 Aedes aegypti MT pSPORT Library Aedes aegypti cDNA clone
Aedes aegypti 38,991 28-Apr-99 AP02 5', mRNA sequence. GB_GSS13:
AQ467517 206 AQ467517 HS_5219_A2_F02_SP6E RPCI-11 Human Male BAC
Library Homo sapiens Homo sapiens 45,255 23-Apr-99 genomic clone
Plate = 795 Col = 4 Row = K, genomic survey sequence. rxa00554 594
GB_EST6: W04418 364 W04418 za43c06.r1 Soares fetal liver spleen
1NFLS Homo sapiens cDNA clone IMAGE: Homo sapiens 39,688 22-Apr-96
295306 5', mRNA sequence. GB_EST35: AL041829 564 AL041829
DKFZp434C0318_s1 434 (synonym: htes3) Homo sapiens cDNA clone Homo
sapiens 40,433 29-Sep-99 DKFZp434C0318 3', mRNA sequence. GB_EST35:
AL041828 386 AL041828 DKFZp434C0318_r1 434 (synonym: htes3) Homo
sapiens cDNA clone Homo sapiens 39,688 29-Sep-99 DKFZp434C0318 5',
mRNA sequence. rxa00555 rxa00560 498 GB_BA1: MTCY7H7A 10451 Z95618
Mycobacterium tuberculosis H37Rv complete genome; segment 39/162.
Mycobacterium 52,727 17-Jun-98 tuberculosis GB_BA1: BAPURF 1885
X91252 B. ammoniagenes purF gene. Corynebacterium 61,092 5-Jun-97
ammoniagenes GB_PL1: YSCMET10A 3650 L26504 Saccharomyces
carlsbergensis assimilatory sulfite reductase (MET10) gene,
Saccharomyces 41,273 7-Feb-95 complete cds. pastorianus rxa00563
2762 GB_BA1: BAFASAA 10549 X64795 B. ammoniagenes FAS gene.
Corynebacterium 66,91 14-OCT-1997 ammoniagenes GB_BA1: MTCY159
33818 Z83863 Mycobacterium tuberculosis H37Rv complete genome;
segment 111/162. Mycobacterium 40,086 17-Jun-98 tuberculosis
GB_BA1: MBU36763 8391 U36763 Mycobacterium bovis fatty acid
synthase gene, complete cds. Mycobacterium bovis 61,178 15-Jul-96
rxa00564 528 GB_PR3: HS833B7 86574 AL008637 Human DNA sequence from
clone 833B7 on chromosome 22q12.3-13.2 Contains Homo sapiens 39,015
23-Nov-99 genes for NCF4 (P40PHOX) protein, cytokine receptor
common beta chain precursor CSF2RB (partial), ESTs, CA repeat, STS,
GSS, complete sequence. GB_HTG3: AC008543 278334 AC008543 Homo
sapiens chromosome 19 clone CIT-HSPC_499B15, *** SEQUENCING Homo
sapiens 36,328 2-Sep-99 IN PROGRESS ***, 134 unordered pieces.
GB_HTG3: AC008543 278334 AC008543 Homo sapiens chromosome 19 clone
CIT-HSPC_499B15, *** SEQUENCING Homo sapiens 36,328 2-Sep-99 IN
PROGRESS ***, 134 unordered pieces. rxa00573 rxa00574 1002
GB_GSS11: AQ301816 481 AQ301816 HS_3174_A1_B04_T7 CIT Approved
Human Genomic Sperm Library D Homo sapiens 43,137 16-DEC-1998 Homo
sapiens genomic clone Plate = 3174 Col = 7 Row = C, genomic survey
sequence. GB_PR3: AC004537 88872 AC004537 Homo sapiens PAC clone
DJ0872F07 from 7q31, complete sequence. Homo sapiens 34,712
9-Apr-98 GB_EST29: AI563059 339 AI563059 EST00183 watermelon lambda
zap library Citrullus lanatus cDNA clone WMLS355 5' Citrullus
lanatus 37,758 26-MAR-1999 similar to unknown protein, mRNA
sequence. rxa00576 795 GB_EST37: AI947508 533 AI947508 603022E09.x1
603 - stressed root cDNA library from Wang/Bohnert lab Zea mays Zea
mays 38,728 19-Aug-99 cDNA, mRNA sequence. GB_GSS11: AQ296770 347
AQ296770 HS_3087_A2_B12_MF CIT Approved Human Genomic Sperm Library
D Homo sapiens 40,058 15-DEC-1998 Homo sapiens genomic clone Plate
= 3087 Col = 24 Row = C, genomic survey sequence. GB_GSS13:
AQ503769 589 AQ503769 RPCI-11-282O13.TV RPCI-11 Homo sapiens
genomic clone RPCI-11-282O13, Homo sapiens 37,993 29-Apr-99 genomic
survey sequence. rxa00577 471 GB_GSS14: AQ533027 638 AQ533027
RPCI-11-351M24.TJ RPCI-11 Homo sapiens genomic clone
RPCI-11-351M24, Homo sapiens 34,944 18-MAY-1999 genomic survey
sequence. GB_PR3: HS440B3 28047 AL022331 Homo sapiens DNA sequence
from clone 440B3 on chromosome 22q12.1-3 Contains Homo sapiens
33,626 23-Nov-99 a pseudogene similar to 60S Ribosomal protein L17.
Contains ESTs and an STS (genomic marker D22S1176), complete
sequence. GB_PL2: ZEU19267 1230 U19267 Zinnia elegans cysteine
proteinase mRNA, complete cds. Zinnia elegans 35,456 26-Aug-96
rxa00578 rxa00582 642 GB_BA1: CORAHPS 2570 L07603 Corynebacterium
glutamicum 3-deoxy-D-arabinoheptulosonate-7-phosphate
Corynebacterium 98,901 26-Apr-93 synthase gene, complete cds.
glutamicum GB_PR3: AC005389 120359 AC005389 Homo sapiens chromosome
17, clone hRPK.601_N_13, complete sequence. Homo sapiens 38,315
14-Aug-98 GB_HTG6: AC008002 126629 AC008002 Drosophila melanogaster
chromosome 2 clone BACR48E08 (D843) RPCI-98 Drosophila melanogaster
32,437 07-DEC-1999 48.E.8 map 21D-21E strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 85 unordered pieces. rxa00585 441
GB_BA1: CORAHPS 2570 L07603 Corynebacterium glutamicum
3-deoxy-D-arabinoheptulosonate-7-phosphate Corynebacterium 98,039
26-Apr-93 synthase gene, complete cds. glutamicum GB_PR4: AC004970
149951 AC004970 Homo sapiens BAC clone DJ1122F04 from
7q11.23-q21.2, complete sequence. Homo sapiens 39,9 27-Aug-99
GB_PR2: HS102G20 99207 Z99127 Human DNA sequence from PAC 102G20 on
chromosome 1q24-q25. Contains ESTS, Homo sapiens 41,509 23-Nov-99
STSs and a predicted CpG island. rxa00586 1005 GB_BA1: MTV017 67200
AL021897 Mycobacterium tuberculosis H37Rv complete genome; segment
48/162. Mycobacterium 56,219 24-Jun-99 tuberculosis GB_BA1:
MLU15183 36800 U15183 Mycobacterium leprae cosmid B1740.
Mycobacterium leprae 55,622 09-MAR-1995 GB_BA1: MTV017 67200
AL021897 Mycobacterium tuberculosis H37Rv complete genome; segment
48/162. Mycobacterium 37,838 24-Jun-99 tuberculosis rxa00587 459
GB_EST37: AI993539 514 AI993539 701496589 A. thaliana, Ohio State
clone set Arabidopsis thaliana cDNA clone Arabidopsis thaliana
40,153 8-Sep-99 701496589, mRNA sequence. GB_GSS10: AQ224941 511
AQ224941 HS_2009_B1_B06_T7 CIT Approved Human Genomic Sperm Library
D Homo sapiens 43,75 20-Sep-98 Homo sapiens genomic clone Plate =
2009 Col = 11 Row = D, genomic survey sequence. GB_EST23: AI099719
475 AI099719 33872 Lambda-PRL2 Arabidopsis thaliana cDNA clone
120M10XP 3', Arabidopsis thaliana 36,752 21-Aug-98 mRNA sequence.
rxa00589 573 GB_PL2: ATAC003673 70575 AC003673 Arabidopsis thaliana
chromosome II BAC F19F24 genomic sequence, Arabidopsis thaliana
39,785 1-Apr-98 complete sequence. GB_PR3: HS427A4 149466 Z98049
Human DNA sequence from PAC 427A4 on chromosome 6q26-q27. Homo
sapiens 35,145 23-Nov-99 Contains ribosomal protein S6 kinase,
RSK3, ESTs, CpG island. rxa00595 GB_PL2: ATAC005724 86671 AC005724
Arabidopsis thaliana chromosome II P1 MSF3 genomic sequence,
complete sequence. Arabidopsis thaliana 39,785 24-Jan-99 rxa00595
rxa00597 393 GB_PR3: AC004659 129577 AC004659 Homo sapiens
chromosome 19, CIT-HSP-87m17 BAC clone, complete sequence. Homo
sapiens 39,459 02-MAY-1998 GB_GSS14: AQ575039 927 AQ575039
nbxb0086L01r CUGI Rice BAC Library Oryza sativa genomic clone
nbxb0086L01r, Oryza sativa 37,786 2-Jun-99 genomic survey sequence.
GB_BA1: NMRRNA 5209 X72495 N. magadii rRNA operon. Natrialba
magadii 39,788 10-Feb-95 rxa00598 rxa00601 414 GB_BA2: AF175719
1368 AF175719 Porphyromona gingivalis strain W50 immunoreactive 51
kD antigen PG52 gene, Porphyromonas gingivalis 35,331 23-Aug-99
complete cds. GB_GSS9: AQ140775 464 AQ140775 HS_3128_A1_B11_MR CIT
Approved Human Genomic Sperm Library D Homo sapiens 40,431
24-Sep-98 Homo sapiens genomic clone Plate = 3128 Col = 21 Row = C,
genomic survey sequence. GB_EST8: AA018824 542 AA018824 ze57e09.s1
Soares retina N2b4HR Homo sapiens cDNA clone IMAGE: 363112 3', Homo
sapiens 40,59 30-Jan-97 mRNA sequence. rxa00602 876 GB_EST30:
AI642687 479 AI642687 vw02h03.x1 Soares mouse mammary gland NbMMG
Mus musculus cDNA clone Mus musculus 40,042 29-Apr-99 IMAGE:
1230773 3', mRNA sequence. GB_EST20: AA879989 412 AA879989
vw03a05.r1 Soares mouse mammary gland NbMMG Mus musculus cDNA clone
Mus musculus 39,948 26-MAR-1998 IMAGE: 1230800 5', mRNA sequence.
GB_EST28: AI481047 438 AI481047 vf91a05.x1 Soares mouse mammary
gland NbMMG Mus musculus cDNA clone Mus musculus 38,128 09-MAR-1999
IMAGE: 851120 3', mRNA sequence. rxa00604 414 GB_HTG2: AC008205
131658 AC008205 Drosophila melanogaster chromosome 3 clone
BACR33F18 (D764) RPCI-98 33.F.18 Drosophila melanogaster 33,907
2-Aug-99 map 96A-96B strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 118 unordered pieces. GB_HTG2: AC008205 131658 AC008205
Drosophila melanogaster chromosome 3 clone BACR33F18 (D764) RPCI-98
33.F.18 Drosophila melanogaster 33,907 2-Aug-99 map 96A-96B strain
y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 118 unordered pieces.
GB_IN1: DMBR7C10 56820 AL121804 Drosophila melanogaster clone
BACR7C10. Drosophila melanogaster 44,267 10-OCT-1999 rxa00610 987
GB_BA1: SME242575 1403 AJ242575 Sinorhizobium meliloti partial oxi1
and dehydrogenase genes, isolate lpu119. Sinorhizobium meliloti
41,76 26-MAY-1999 GB_PR3: AC004655 134929 AC004655 Homo sapiens
Xp22-140-141 BAC GSHB-128G5 (Genome Systems Human SAC Homo sapiens
38,422 17-Sep-98 library) complete sequence. GB_PR3: HS598F2 99886
AL021579 Human DNA sequence from clone 598F2 on chromosome
1q23.1-24.3 Contains Homo sapiens 38,351 23-Nov-99 ESTs, STS and
GSS, complete sequence. rxa00611 1599 GB_HTG2: AC007108 190000
AC007108 Homo sapiens chromosome 4, *** SEQUENCING IN PROGRESS***,
Homo sapiens 17,451 17-MAR-1999 24 unordered pieces. GB_HTG2:
AC007108 190000 AC007108 Homo sapiens chromosome 4, *** SEQUENCING
IN PROGRESS ***, Homo sapiens 17,451 17-MAR-1999 24 unordered
pieces. GB_HTG4: AC010893 176178 AC010893 Homo sapiens chromosome
unknown clone NH0480A20, WORKING DRAFT Homo sapiens 35,819
29-OCT-1999 SEQUENCE, in unordered pieces. rxa00613 576 GB_IN2:
AC004361 87747 AC004361 Drosophila melanogaster DNA sequence (P1
DS07851 (D49)), complete sequence. Drosophila melanogaster 35,081
29-MAY-1998 GB_PL2: AC006268 105420 AC006268 Arabidopsis thaliana
BAC T24G23 from
chromosome IV near 21 cM, Arabidopsis thaliana 43,682 1-Jan-99
complete sequence. GB_BA1: MLCB596 38426 AL035472 Mycobacterium
leprae cosmid B596. Mycobacterium leprae 35,026 27-Aug-99 rxa00614
1038 GB_BA1: MTV025 121125 AL022121 Mycobacterium tuberculosis
H37Rv complete genome; segment 155/162. Mycobacterium 53,061
24-Jun-99 tuberculosis GB_BA1: SCH66 9153 AL049731 Streptomyces
coelicolor cosmid H66. Streptomyces coelicolor 52,817 29-Apr-99
GB_EST14: AA446728 411 AA446728 zw84f03.r1
Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone Homo sapiens
36,548 3-Jun-97 IMAGE: 783677 5', mRNA sequence. rxa00616 rxa00617
351 GB_PL1: AB009030 2589 AB009030 Panax ginseng OSCPNY1 mRNA for
beta-Amyrin Synthase, complete cds. Panax ginseng 39,048
03-OCT-1998 GB_PR3: HS905G11 122469 AL035045 Human DNA sequence
from clone 905G11 on chromosome 20p11.2-12.1. Homo sapiens 39,255
23-Nov-99 Contains STSs, GSSs and genomic marker D20S182, complete
sequence. GB_RO: MMT1CPS 8147 X15147 Mouse Tla region T1c
pseudogene for class I antigen major Mus musculus 36,311 19-Feb-90
histocompatibility complex. rxa00628 531 GB_HTG5: AC010674 220575
AC010674 Homo sapiens chromosome 15 clone RP11-430B1 map 15q21, ***
SEQUENCING Homo sapiens 37,714 5-Nov-99 IN PROGRESS ***, 46 ordered
pieces. GB_HTG5: AC010674 220575 AC010674 Homo sapiens chromosome
15 clone RP11-430B1 map 15q21, *** SEQUENCING Homo sapiens 39,293
5-Nov-99 IN PROGRESS ***, 46 ordered pieces. rxa00631 1578 GB_BA1:
BRLBIOAD 2272 D14083 Brevibacterium flavum genes for
7,8-diaminopelargonic acid aminotransferase Corynebacterium 47,368
3-Feb-99 and dethiobiotin synthetase, complete cds. glutamicum
GB_PAT: E04041 675 E04041 DNA sequence coding for
desthiobiotinsynthetase. Corynebacterium 46,552 29-Sep-97
glutamicum GB_EST20: AA820386 453 AA820386 LD23968.5prime LD
Drosophila melanogaster embryo pOT2 Drosophila Drosophila
melanogaster 45,679 25-Feb-99 melanogaster cDNA clone LD23968
5prime, mRNA sequence. rxa00637 876 GB_HTG2: AC007589 134659
AC007589 Drosophila melanogaster chromosome 3 clone BACR20D10
(D667) RPCI-98 20.D.10 Drosophila melanogaster 32,102 2-Aug-99 map
82D-82E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 73
unordered pieces. GB_HTG2: AC007589 134659 AC007589 Drosophila
melanogaster chromosome 3 clone BACR20D10 (D667) RPCI-98 20.D.10
Drosophila melanogaster 32,102 2-Aug-99 map 82D-82E strain y; cn bw
sp, *** SEQUENCING IN PROGRESS ***, 73 unordered pieces. GB_HTG3:
AC009212 125452 AC009212 Drosophila melanogaster chromosome 3 clone
BACR01A18 (D669) RPCI-98 01.A.18 Drosophila melanogaster 37,126
23-Aug-99 map 82E-82F strain y; cn bw sp, *** SEQUENCING IN
PROGRESS ***, 119 unordered pieces. rxa00646 541 GB_HTG1: AP000488
123363 AP000488 Homo sapiens chromosome 11 clone B759H8 map 11q23,
*** SEQUENCING Homo sapiens 38,264 13-Sep-99 IN PROGRESS ***, in
unordered pieces. GB_HTG1: AP000488 123363 AP000488 Homo sapiens
chromosome 11 clone B759H8 map 11q23,*** SEQUENCING Homo sapiens
38,264 13-Sep-99 IN PROGRESS ***, in unordered pieces. GB_HTG1:
AP000488 123363 AP000488 Homo sapiens chromosome 11 clone B759H8
map 11q23, *** SEQUENCING Homo sapiens 36,484 13-Sep-99 IN PROGRESS
***, in unordered pieces. rxa00647 756 GB_GSS13: AQ431426 536
AQ431426 HS_5140_A2_E01_T7A RPCI-11 Human Male BAC Library Homo
sapiens 35,635 31-MAR-1999 Homo sapiens genomic clone Plate = 716
Col = 2 Row = I, genomic survey sequence. GB_OV: CHKP4HA 3149
M26217 Chicken prolyl 4-hydroxylase alpha subunit gene, 3' end.
Gallus gallus 40,655 28-Apr-93 GB_HTG2: AC008271 168302 AC008271
Homo sapiens clone NH0123E16, *** SEQUENCING IN PROGRESS ***, Homo
sapiens 37,417 31-Jul-99 2 unordered pieces. rxa00649 579 GB_PR2:
AC002563 136436 AC002563 Human PAC clone 127H14 from 12q, complete
sequence. Homo sapiens 37,937 26-Sep-97 GB_HTG3: AC011466 165953
AC011466 Home sapiens chromosome 19 clone CIT-HSPC_453G23, ***
SEQUENCING Homo sapiens 38,179 07-OCT-1999 IN PROGRESS ***, 74
unordered pieces. GB_HTG3: AC011466 165953 AC011466 Homo sapiens
chromosome 19 clone CIT-HSPC_453G23, *** SEQUENCING Homo sapiens
38,179 07-OCT-1999 IN PROGRESS ***, 74 unordered pieces. rxa00652
rxa00653 rxa00654 1389 GB_EST1: Z34080 271 Z34080 ATTS3128
Grenoble-B Arabidopsis thaliana cDNA clone GBGe328 5', Arabidopsis
thaliana 40,37 6-Jun-94 mRNA sequence. GB_PR3: AC004460 113803
AC004460 Homo sapiens PAC clone DJ1086D14, complete sequence. Homo
sapiens 36,15 24-MAR-1998 GB_GSS6: AQ835185 571 AQ835185
HS_4832_A1_E02_T7A CIT Approved Human Genomic Sperm Library D Homo
sapiens 39,429 27-Aug-99 Homo sapiens genomic clone Plate = 4832
Col = 3 Row = I, genomic survey sequence. rxa00656 384 GB_HTG3:
AC009948 172463 AC009948 Homo sapiens clone NH0065L03, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 43,164 25-Sep-99 2
unordered pieces. GB_HTG3: AC009948 172463 AC009948 Homo sapiens
clone NH0065L03, *** SEQUENCING IN PROGRESS ***, Homo sapiens
43,164 25-Sep-99 2 unordered pieces. GB_GSS13: AQ462899 522
AQ462899 HS_5212_A1_C09_T7A RPCI-11 Human Male BAC Library Homo
sapiens Homo sapiens 42,529 23-Apr-99 genomic clone Plate = 788 Col
= 17 Row = E, genomic survey sequence. rxa00657 1026 GB_BA2:
AF064700 3481 AF064700 Rhodococcus sp. NO1-1 CprS and CprR genes,
complete cds. Rhodococcus sp. NO1-1 40,558 15-Jul-98 GB_PR3:
AC005346 38849 AC005346 Homo sapiens chromosome 16, cosmid clone
2H2 (LANL), complete sequence. Homo sapiens 35,553 31-Jul-98
GB_HTG3: AC008905 129915 AC008905 Homo sapiens chromosome 5 clone
CITB-H1_2259114, *** SEQUENCING Homo sapiens 37,179 3-Aug-99 IN
PROGRESS ***, 40 unordered pieces. rxa00661 813 GB_PL2: AC006193
118335 AC006193 Arabidopsis thaliana chromosome I BAC F13O11
genomic sequence, Arabidopsis thaliana 35,513 11-Jun-99 complete
sequence. GB_RO: MMFABPE 6593 AJ223066 Mus musculus Fabpe gene. Mus
musculus 37,5 27-Jul-98 GB_PL2: AC006193 118335 AC006193
Arabidopsis thaliana chromosome I BAC F13O11 genomic sequence,
Arabidopsis thaliana 33,552 11-Jun-99 complete sequence. rxa00662
1392 GB_EST29: AI551960 718 AI551960 vi48d09.y1 Beddington mouse
embryonic region Mus musculus cDNA Mus musculus 39,972 23-MAR-1999
clone IMAGE: 907025 5' similar to gb: D10576 Mouse mRNA for
ubiqultin activating enzyme E1 (MOUSE);, mRNA sequence. GB_BA2:
AE000633 19734 AE000633 Helicobacter pylori 26695 section 111 of
134 of the complete genome. Helicobacter pylori 26695 36,606
6-Apr-99 GB_GSS10: AQ216730 529 AQ216730 HS_2262_A1_G06_MR CIT
Approved Human Genomic Sperm Library D Homo sapiens 32,703
19-Sep-98 Homo sapiens genomic clone Plate = 2262 Col = 11 Row = M,
genomic survey sequence. rxa00666 1038 GB_HTG3: AC009205 113482
AC009205 Drosophila melanogaster chromosome 2 clone BACR04C20
(D1035) Drosophila melanogaster 36,713 17-Sep-99 RPCI-98 04.C.20
map 36E-37C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 101
unordered pieces. GB_EST25: AI259480 626 AI259480 LP02903.5prime LP
Drosophila melanogaster tarval-early pupal pOT2 Drosophila
melanogaster 37,173 17-Nov-98 Drosophila melanogaster cDNA clone
LP02903 5prime, mRNA sequence. GB_HTG3: AC009205 113482 AC009205
Drosophila melanogaster chromosome 2 clone BACR04C20 Drosophila
melanogaster 36,713 17-Sep-99 (D1035) RPCI-98 04.C.20 map 36E-37C
strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 101 unordered
pieces. rxa00667 1137 GB_PAT: AR048317 2627 AR048317 Sequence 3
from patent U.S. Pat. No. 5821090. Unknown. 39,805 29-Sep-99
GB_PAT: A46560 2627 A46560 Sequence 3 from Patent WO9526406.
Eremothecium gossypll 39,805 07-MAR-1997 GB_VI: HEHCMVCG 229354
X17403 Human cytomegalovirus strain AD169 complete genome. human
herpesvirus 5 39,854 10-Feb-99 rxa00676 870 GB_HTG1: CEY38F1 178443
Z98861 Caenorhabditis elegans chromosome II clone Y38F1, ***
SEQUENCING Caenorhabditis elegans 35,88 03-DEC-1998 IN PROGRESS
***, in unordered pieces. GB_HTG1: CEY38F1 178443 Z98861
Caenorhabditis elegans chromosome II clone Y38F1, *** SEQUENCING
Caenorhabditis elegans 35,88 03-DEC-1998 IN PROGRESS ***, in
unordered pieces. GB_PR3: HS934G17 107603 AL021155 Homo sapiens DNA
sequence from PAC 934G17 on chromosome 1p36.21. Homo sapiens 38,489
23-Nov-99 Contains the alternatively spliced CLCN6 gene for
chloride chanel proteins CLC-6A (KIAA0046) -B, -C and -D, the
alternatively spliced NPPA gene coding for Atrial Natriuretic
Factor ANF precursor (Atrial Natriuretic peptide ANP,
Prepronatriodilatin), the NPPB gene for Brain Natriuretic Protein
BNP, and a pseudogene similar to SBF1 (and other
Myotubularin-related protein genes). Contains ESTs, STSs and the
genomic marker D1S2740, complete sequence. rxa00678 858 GB_PR2:
CNS00004 205573 AL049778 Human chromosome 14 DNA sequence *** IN
PROGRESS *** BAC R-643C12 Homo sapiens 33,138 17-Jun-99 of RPCt-11
library from chromosome 14 of Homo sapiens (Human), complete
sequence. GB_GSS1: AG000894 723 AG000894 Homo sapiens genomic DNA,
21q region, clone: 64E11X19, Homo sapiens 37,391 6-Feb-99 genomic
survey sequence. GB_IN1: TSMIEXRNA 481 X90847 Trypanosoma simiae
mini-exon DNA. Trypanosoma simiae 35,135 15-Feb-99 rxa00691 1053
GB_EST26: AA899042 505 AA899042 UI-R-E0-bz-a-06-0-UI.s2 UI-R-E0
Rattus norvegicus cDNA clone Rattus norvegicus 41,4 4-Jul-99
UI-R-E0-bz-a-06-0-UI 3' similar to gi|485266|gb|U09256|RNU09256
Rattus norvegicus Sprague-Dawley transketolase mRNA, complete cds,
mRNA sequence. GB_RO: RNU09256 2098 U09256 Rattus norvegicus
Sprague-Dawley transketolase mRNA, complete cds. Rattus norvegicus
39,652 11-MAY-1994 GB_EST29: AI599628 510 AI599628 EST251331
Normalized rat embryo, Bento Soares Rattus sp. cDNA clone REMEH65
Rattus sp. 39,096 21-Apr-99 3' end, mRNA sequence. rxa00692 1257
GB_PL2: SPU66305 8226 U66305 Schizosaccharomyces pombe ABC
transporter (mam1) gene, complete cds. Schizosaccharomyces 36,842
30-Jul-97 pombe GB_PL1: SPBC25B2 26016 AL031853 S. pombe chromosome
II cosmid c25B2. Schizosaccharomyces 36,803 09-OCT-1998 pombe
GB_PL1: SPBC2G5 23645 AL033385 S. pombe chromosome II cosmid c2G5.
Schizosaccharomyces 36,803 04-DEC-1998 pombe rxa00693 606 GB_BA2:
RRU65510 16259 U65510 Rhodospirillum rubrum CO-induced hydrogenase
operon (cooM, cooK, cooL, Rhodospirillum rubrum 41,97 9-Apr-97
cooX, cooU. cooH) genes, iron sulfur protein (cooF) gene, carbon
monoxide dehydrogenase (cooS) gene, carbon monoxide dehydrogenase
accessory proteins (cooC, cooT, cooJ) genes, putative
transcriptional activator (cooA) gene, nicotinate-nucleotide
pyrophosphorylase (nadC) gene, complete cds, L- aspartate oxidase
(nadB) gene, and alkyl hydroperoxide reductase (ahpC) gene, partial
cds. GB_PL1: LETHM27 1152 X95296 L. esculentum mRNA for THM27
protein. Lycopersicon esculentum 38,919 10-Jun-96 GB_EST38:
AW033855 646 AW033855 EST277426 tomato callus, TAMU Lycopersicon
esculentum cDNA clone cLEC29F6 Lycopersicon esculentum 35,945
15-Sep-99 similar to transcription factor, myb-related, mRNA
sequence. rxa00701 498 GB_EST34: AI785570 454 AI785570 uj44d03.x1
Sugano mouse liver mlia Mus musculus cDNA clone IMAGE: 1922789 Mus
musculus 37,565 2-Jul-99 3' similar to gb: Z28407 60S RIBOSOMAL
PROTEIN L8 (HUMAN);, mRNA sequence. GB_EST25: AI256147 684 AI256147
ui95e12.x1 Sugano mouse liver mlia Mus musculus cDNA clone IMAGE:
1890190 Mus musculus 41,232 12-Nov-98 3' similar to gb: Z28407 60S
RIBOSOMAL PROTEIN L8 (HUMAN);, mRNA sequence. GB_BA1: CARCG12 2079
X14979 C. aurantiacus reaction center genes 1 and 2. Chloroflexus
aurantiacus 36,943 23-Apr-91 rxa00704 750 GB_EST15: AA497266 456
AA497266 fa04f08.s1 Zebrafish ICRFzfls Danio rerio cDNA clone 3A13
3', mRNA sequence. Danio rerio 38,631 30-Jun-97 GB_EST36: AI884217
515 AI884217 fc75e10.x1 Zebrafish WashU MPIMG EST Danio rerio cDNA
3', mRNA sequence. Danio rerio 36,012 26-Jul-99 GB_HTG1: CEY43F8_1
110000 Z95393 Caenorhabditis elegans chromosome V clone Y43F8, ***
SEQUENCING Caenorhabditis elegans 37,889 Z95393 IN PROGRESS ***, in
unordered pieces. rxa00707 906 GB_GSS8: AQ013755 715 AQ013755
RPCI11-23F24.TKBF RPCI-11 Homo sapiens genomic clone RPCI-11-23F24,
Homo sapiens 41,724 14-Apr-99 genomic survey sequence. GB_GSS3:
B86449 434 B86449 RPCI11-23F24.TV RPCI-11 Homo sapiens genomic
clone RPCI-11-23F24, Homo sapiens 42,936 9-Apr-99 genomic survey
sequence. GB_GSS5: AQ797072 449 AQ797072 nbxb0071D10f CUGI Rice BAC
Library Oryza sativa genomic clone nbxb0071D10f, Oryza sativa
39,101 4-Aug-99 genomic survey sequence. rxa00712 819 GB_BA2:
AF011544 7527 AF011544 Bacillus subtilis
phosphoribosylaminoimidazote-carboxamide Bacillus subtilis 36,927
06-OCT-1997 formyltransferase (purH-J) gene, partial cds,
phosphoribosylglycinamide synthetase (purD), YecA (yecA), putative
adenine deaminase (yecB), YecC (yecC), and YecD (yecD) genes,
complete cds, and putative glutamate synthase (yecE) gene, partial
cds. GB_BA2: AF011544 7527 AF011544 Bacillus subtilis
phosphoribosylaminoimidazole-carboxam;de formyltransferase Bacillus
subtilis 39,752 06-OCT-1997 (purH-J) gene, partial cds,
phosphoribosylglycinamide synthetase (purD), YecA (yecA), putative
adenine deaminase (yecB), YecC (yecC), and YecD (yecD) genes,
complete cds, and putative glutamate synthase (yecE) gene, partial
cds. rxa00713 1056 GB_PAT: I92037 241 I92037 Sequence 4 from patent
U.S. Pat. No. 5726299. Unknown. 99,048 01-DEC-1998 GB_PAT: I78748
241 I78748 Sequence 4 from patent U.S. Pat. No. 5693781. Unknown.
99,048 3-Apr-98 GB_HTG3: AC009281 221178 AC009281 Homo sapiens
chromosome 15 clone 8_C_22 map 15, *** SEQUENCING Homo sapiens
36,255 12-Aug-99 IN PROGRESS ***, 49 unordered pieces. rxa00714 684
GB_PL1: CCR5839 871 AJ005839 Cyclotella cryptica mRNA for
fucoxanthin chlorophyll a/c binding protein, fcp12. Cyclotella
cryptica 36,364 30-Jul-98 GB_PR2: HS1002M8 111768 AL035454 Human
DNA sequence from clone 1002M8 on chromosome 20p11.21-11.23, Homo
sapiens 36,444 23-Nov-99 complete sequence. GB_PR2: HS1002M8 111768
AL035454 Human DNA sequence from clone 1002M8 on chromosome
20p11.21-11.23. Homo sapiens 34,894 23-Nov-99 complete sequence.
rxa00716 636 GB_PAT: I78753 1187 I78753 Sequence 9 from patent U.S.
Pat. No. 5693781. Unknown. 36,022 3-Apr-98 GB_PAT: I92042 1187
I92042 Sequence 9 from patent U.S. Pat. No. 5726299. Unknown.
36,022 01-DEC-1998 GB_HTG3: AC005769 200000 AC005769 Homo sapiens
chromosome 4, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,745
21-Aug-99 5 unordered pieces. rxa00719 1752 GB_BA2: U32687 11847
U32687 Haemophilus influenzae Rd section 2 of 163 of the complete
genome. Haemophilus influenzae Rd 36,937 29-MAY-1998 GB_EST13:
AA333802 357 AA333602 EST37710 Embryo, 8 week | Homo sapiens cDNA
5' end similar to guanine Homo sapiens 45,938 21-Apr-97
nucleotide-binding protein rap2, ras-oncogene related, mRNA
sequence. GB_BA2: U32687 11847 U32687 Haemophilus influenzae Rd
section 2 of 163 of the complete genome. Haemophilus influenzae Rd
36,39 29-MAY-1998 rxa00720 789 GB_EST1: M61974 437 M61974 EST00024
Fetal brain, Stratagene (cat#936206) Homo sapiens cDNA Homo sapiens
40,138 26-MAY-1992 clone HFBA87, mRNA sequence. GB_EST3: R73776 389
R73776 yi55h07.r1 Soares placenta Nb2HP Homo sapiens cDNA clone
IMAGE: 143197 5', Homo sapiens 41,818 5-Jun-93 mRNA sequence.
GB_EST35: AL043192 793 AL043192 DKFZp434G0723_r1 434 (synonym:
htes3) Homo sapiens cDNA clone Homo sapiens 38,571 29-Sep-99
DKFZp434G0723 5', mRNA sequence. rxa00722 1088 GB_HTG3: AC008573
205755 AC008573 Homo sapiens chromosome 5 clone CIT-HSPC_551|11,
*** SEQUENCING Homo sapiens 38,506 3-Aug-99 IN PROGRESS ***, 95
unordered pieces. GB_HTG3: AC008573 205755 AC008573 Homo sapiens
chromosome 5 clone CIT-HSPC_551|11, *** SEQUENCING Homo sapiens
38,506 3-Aug-99 IN PROGRESS ***, 95 unordered pieces. GB_BA1:
MTV014 58280 AL021646 Mycobacterium tuberculosis H37Rv complete
genome; segment 137/162. Mycobacterium 41,392 18-Jun-98
tuberculosis rxa00724 2100 GB_BA1: SC7A1 32039 AL034447
Streptomyces coelicolor cosmid 7A1. Streptomyces coelicolor 54,858
15-DEC-1998 GB_BA1: BSY13937 27779 Y13937 Bacillus subtilis genomic
DNA from the spoVM region. Bacillus subtilis 47,01 30-MAR-1998
GB_BA2: L78127 1225 L78127 Enterococcus faecium genomic DNA
fragment. Enterococcus faecium 36,88 18-Aug-99 rxa00726 614 GB_BA1:
BACJH642 282700 D84432 Bacillus subtilis DNA, 283 Kb region
containing skin element. Bacillus subtilis 56,694 6-Feb-99 GB_BA1:
BSUB0013 218470 Z99116 Bacillus subtilis complete genome (section
13 of 21): from 2395261 to 2613730. Bacillus subtilis 36,513
26-Nov-97 GB_BA1: SC4H8 15560 AL020958 Streptomyces coelicolor
cosmid 4H8. Streptomyces coelicolor 35,073 10-DEC-1997 rxa00729
rxa00730 930 GB_HTG3: AC010758 145821 AC010758 Homo sapiens clone
1_B_18, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,738
22-Sep-99 20 unordered pieces. GB_HTG3: AC010758 145821 AC010758
Homo sapiens clone 1_B_18, *** SEQUENCING IN PROGRESS ***, Homo
sapiens 35,738 22-Sep-99 20 unordered pieces. GB_GSS13: AQ469090
414 AQ469090 CITBI-E1-2596D12.TF CITBI-E1 Homo sapiens genomic
clone 2596D12, Homo sapiens 36,842 23-Apr-99 genomic survey
sequence. rxa00731 2619 GB_BA1: CGLYSI 4232 X60312 C. glutamicum
lysi gene for L-lysine permease. Corynebacterium 100 30-Jan-92
glutamicum GB_BA1: CGLYSI 4232 X60312 C. glutamicum lysi gene for
L-lysine permease. Corynebacterium 37,645 30-Jan-92 glutamicum
rxa00738 386 GB_BA1: MTCY10G2 38970 Z92539 Mycobacterium
tuberculosis H37Rv complete genome: segment 47/162. Mycobacterium
54,427 17-Jun-98 tuberculosis GB_HTG1: HSJ564F22 106277 AL080249
Homo sapiens chromosome 20 clone RP4-564F22, *** SEQUENCING Homo
sapiens 44 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1:
HSJ564F22 106277 AL080249 Homo sapiens chromosome 20 clone
RP4-564F22, *** SEQUENCING Homo sapiens 44 23-Nov-99 IN PROGRESS
***, in unordered pieces. rxa00740 702 GB_PL2: AF100167 1557
AF100167 Glycine max unknown mRNA. Glycine max 35,823 4-Nov-98
GB_EST28: AI465702 268 AI465702 vw83g01.y1 Stratagene mouse skin
(#937313) Mus musculus cDNA clone IMAGE: Mus musculus 43,226
09-MAR-1999 1261584 5', mRNA sequence. GB_EST20: AA856157 359
AA856157 vw83g01.r1 Stratagene mouse skin (#937313) Mus musculus
cDNA clone IMAGE: Mus musculus 43,226 06-MAR-1998 1261584 5', mRNA
sequence. rxa00741 1056 GB_HTG2: AC007185 199340 AC007185
Drosophila melanogaster chromosome 2 clone BACR44N04 (D545) RPCI-98
Drosophila melanogaster 39,583 2-Aug-99 44.N.4 map 36A-36A strain
y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 50 unordered pieces.
GB_HTG2: AC007185 199340 AC007185 Drosophila melanogaster
chromosome 2 clone BACR44N04 (D545) RPCI-98 Drosophila melanogaster
39,583 2-Aug-99 44.N.4 map 36A-36A strain y: cn bw sp. ***
SEQUENCING IN PROGRESS ***, 50 unordered pieces. GB_PL2: F17123
134784 AF160182 Arabidopsis thaliana BAC F17I23. Arabidopsis
thaliana 37,788 20-Jun-99 rxa00742 1773 GB_IN1: CEC05C10 26263
Z48178 Caenorhabditis elegans cosmid C05C10, complete sequence.
Caenorhabditis elegans 39,243 2-Sep-99 GB_IN1: CEC05C10 26263
Z48178 Caenorhabditis elegans cosmid C05C10, complete sequence.
Caenorhabditis elegans 38,041 2-Sep-99 rxa00743 546 GB_GSS9:
AQ093649 320 AQ093649 HS_3022_A1_E06_MR CIT Approved Human Genomic
Sperm Library D Homo sapiens 34,277 27-Aug-98 Homo sapiens genomic
clone Plate = 3022 Col = 11 Row = I, genomic survey sequence.
GB_GSS9: AQ093649 320 AQ093649 HS_3022_A1_E06_MR CIT Approved Human
Genomic Sperm Library D Homo sapiens 34,277 27-Aug-98 Homo sapiens
genomic clone Plate = 3022 Col = 11 Row = I, genomic survey
sequence. rxa00745 657 GB_HTG2: AC008195 130309 AC008195 Drosophila
melanogaster chromosome 3 clone BACR42I20 (D748) RPCI-98 42.I.20
Drosophila melanogaster 38,095 2-Aug-99 map 93F-93F strain y; cn bw
sp. *** SEQUENCING IN PROGRESS ***, 77 unordered pieces. GB_IN2:
DMU53190 3477 U53190 Drosophila melanogaster Camguk (cmg) mRNA,
complete cds. Drosophila melanogaster 39,623 30-Nov-98 GB_HTG2:
AC008195 130309 AC008195 Drosophila melanogaster chromosome 3 clone
BACR42I20 (D748) RPCI-98 42.I.20 Drosophila melanogaster 38,095
2-Aug-99 map 93F-93F strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 77 unordered pieces. rxa00746 1314 GB_HTG3: AC010076 148614
AC010076 Homo sapiens chromosome 15 clone BAC 64K10 map 14q25, Homo
sapiens 36,336 11-Sep-99 LOW-PASS SEQUENCE SAMPLING. GB_HTG3:
AC010076 148614 AC010076 Homo sapiens chromosome 15 clone BAC 64K10
map 14q25, Homo sapiens 36,336 11-Sep-99 LOW-PASS SEQUENCE
SAMPLING. GB_PR3: MS402G11 177241 AL022328 Human DNA sequence from
clone 402G11 on chromosome 22q13.31-13.33 Homo sapiens 38,752
23-Nov-99 Contains genes for SAPK3 (stress-activated protein kinase
3), PRKM11 (protein kinase mitogen-activated 11), KIAA0315, ESTs,
GSSs and CpG islands, complete sequence. rxa00747 711 GB_HTG4:
AC010081 176777 AC010081 Homo sapiens clone NH0065E07, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 37,016 29-OCT-1999 1
unordered pieces. GB_HTG4: AC010081 176777 AC010081 Homo sapiens
clone NH0065E07, *** SEQUENCING IN PROGRESS ***, Homo sapiens
37,016 29-OCT-1999 1 unordered pieces. GB_HTG3: AC011194 196098
AC011194 Mus musculus chromosome 11 clone 196_F_5 map 11, ***
SEQUENCING Mus musculus 38,735 01-OCT-1999 IN PROGRESS ***, 32
unordered pieces. rxa00748 567 GB_GSS13: AQ457887 478 AQ457887
HS_5189_B2_B06_SP6E RPCI-11 Human Male BAC Library Homo sapiens
Homo sapiens 37,844 23-Apr-99 genomic clone Plate = 765 Col = 12
Row = D, genomic survey sequence. GB_IN1: EHEXRIDRI 170 X58630 E.
histolytica extrachromosomal ribosomal DNA for DRA I repeat unit.
Entamoeba histolytica 42,353 13-Aug-91 GB_IN1: EHEXRDNA 3699 X61182
E. histolytica extrachromosomal ribasomal DNA downstream of rRNA
genes. Entamoeba histolytica 38,905 2-Sep-96 rxa00749 822 GB_BA1:
BSUB0003 209100 Z99106 Bacillus subtilis complete genome (section 3
of 21): from 402751 to 611850. Bacillus subtilis 37,238 26-Nov-97
GB_BA1: AB001488 148068 AB001488 Bacillus subtilis genome sequence,
148 kb sequence of the region Bacillus subtilis 37,238 13-Feb-99
between 35 and 47 degree. rxa00750 GB_HTG3: AC008060 161486
AC008060 Homo sapiens clone DJ0912I13, *** SEQUENCING IN PROGRESS
***, Homo sapiens 39,474 13-Aug-99 4 unordered pieces. rxa00751 951
GB_PR4: AC006449 286758 AC006449 Homo sapiens chromosome 17, clone
hCIT.58_E_17, complete sequence. Homo sapiens 38,223 23-OCT-1999
GB_HTG2: AC002118 170891 AC002118 Homo sapiens chromosome 17 clone
303_E_14, *** SEQUENCING Homo sapiens 37,112 13-Feb-98 IN PROGRESS
***, 20 unordered pieces. GB_HTG2: AC002118 170891 AC002118 Homo
sapiens chromosome 17 clone 303_E_14, *** SEQUENCING Homo sapiens
37,112 13-Feb-98 IN PROGRESS ***, 20 unordered pieces. rxa00752 552
GB_PL2: F5K24 109786 AF128395 Arabidopsis thaliana BAC F5K24.
Arabidopsis thaliana 38,899 03-MAR-1999 GB_BA1: MBHRDED 6300 Y09870
M. barkeri hdrE & hdrD genes, ORF1, ORF2, ORF3 & ORF4.
Methanosarcina barkeri 40,609 04-DEC-1998 GB_PL1: SC9920 23498
Z48639 S. cerevisiae chromosome XIII cosmid 9920. Saccharomyces
cerevisiae 35,754 11-Aug-97 rxa00757 1377 GB_PAT: E13655 2260
E13655 gDNA encoding glucose-6-phosphate dehydrogenase.
Corynebacterium 46,045 24-Jun-98 glutamicum GB_GSS9: AQ103710 369
AQ103710 HS_3092_B1_C01_MF CIT Approved Human Genomic Sperm Library
D Homo sapiens 36,339 27-Aug-98 Homo sapiens genomic clone Plate =
3092 Col = 1 Row = F, genomic survey sequence. GB_HTG3: AC009305
167705 AC009305 Homo sapiens clone NH0153B21, *** SEQUENCING IN
PROGRESS ***, Homo sapiens 36,691 13-Aug-99 3 unordered pieces.
rxa00763 906 GB_BA1: SC7B7 13800 AL009199 Streptomyces coelicolor
cosmid 7B7. Streptomyces coelicolor 39,013 02-DEC-1997 GB_HTG2:
HSJ473J16 203460 AL109942 Homo sapiens chromosome 6 clone
RP3-473J16 map q25.3-26, *** SEQUENCING Homo sapiens 38,192
03-DEC-1999 IN PROGRESS ***, in unordered pieces. GB_HTG2:
HSJ473J16 203460 AL109942 Homo sapiens chromosome 6 clone
RP3-473J16 map q25.3-26, *** SEQUENCING Homo sapiens 38,192
03-DEC-1999 IN PROGRESS ***, in unordered pieces. rxa00765 810
GB_BA1: MTV043 68848 AL022004 Mycobacterium tuberculosis H37Rv
complete genome; segment 40/162. Mycobacterium 38,568 24-Jun-99
tuberculosis GB_BA2: PAU93274 8008 U93274 Pseudomonas aeruginosa
YafE (yafE), LeuB (leuB), Asd (asd), Pseudomonas aeruginosa 37,656
23-Jun-98 FimV (fimV), and HisT (hisT) genes, complete cds; TrpF
(trpF) gene, partial cds: and unknown gene. GB_BA1: MTCY31 37630
Z73101 Mycobacterium tuberculosis H37Rv complete genome; segment
41/162. Mycobacterium 38,209 17-Jun-98 tuberculosis rxa00768 1242
GB_HTG5: AC008194 194555 AC008194 Drosophila melanogaster
chromosome X clone BACR49A05 (D745) RPCI-98 49.A.5 Drosophila
melanogaster 34,078 15-Nov-99 map 18A-18 Astrain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 90 unordered pieces. GB_HTG5: AC008194
194555 AC008194 Drosophila melanogaster chromosome X clone
BACR49A05 (D745) RPCI-98 49.A.5 Drosophila melanogaster 31,194
15-Nov-99 map 18A-18A strain y; cn bw sp, *** SEQUENCING IN
PROGRESS ***, 90 unordered pieces. GB_BA2: AF044495 9599 AF044495
Agrobacterium tumefaciens chemotaxis operon, complete Agrobacterium
tumefaciens 40,165 2-Jul-98 sequence. rxa00769 336 GB_PR3: AC003068
42184 AC003068 Human Cosmid g5129z059 from 7q31.3. complete
sequence. Homo sapiens 35,152 6-Nov-97 GB_PR2: HSAC000374 41585
AC000374 Human cosmid g1980a170, complete sequence. Homo sapiens
35,152 12-MAR-1997 GB_PR3: AC003068 42184 AC003068 Human Cosmid
g5129z059 from 7q31.3, complete sequence. Homo sapiens 37,309
6-Nov-97 rxa00771 942 GB_PR2: HS172K2 131234 Z84814 Human DNA
sequence from PAC 172K2 on chromosome 6 Homo sapiens 34,719
23-Nov-99 contains HLA CLASS II DRA pseudogene, DRB3*01012 genes,
DRB9 pseudogene butyrophilin precursor and ESTs. GB_HTG1: HSA555E18
1177 AL121780 Homo sapiens chromosome 20 clone RP11-555E18, Homo
sapiens 41,45 23-Nov-99 *** SEQUENCING IN PROGRESS ***, in
unordered pieces. GB_HTG1: HSA555E18 1177 AL121780 Homo sapiens
chromosome 20 clone RP11-555E18, Homo sapiens 41,45 23-Nov-99 ***
SEQUENCING IN PROGRESS ***, in unordered pieces. rxa00781 411
GB_PR3: HS48A11 129294 AL031132 Human DNA sequence from clone
48A11 on chromosome Homo sapiens 37,284 23-Nov-99 20p12 Contains
EST, STS, GSS, complete sequence. GB_IN1: CELC03B1 42297 U40952
Caenorhabditis elegans cosmid C03B1. Caenorhabditis elegans 38,177
25-Nov-95 GB_PR3: HS48A11 129294 AL031132 Human DNA sequence from
clone 48A11 on chromosome 20p12 Homo sapiens 35,162 23-Nov-99
Contains EST, STS, GSS, complete sequence. rxa00785 680 GB_EST11:
AA223451 349 AA223451 zr06d01.r1 Stratagene NT2 neuronal precursor
937230 Homo sapiens cDNA clone Homo sapiens 38,682 19-Feb-97 IMAGE:
6506895', mRNA sequence. GB_EST9: AA081255 446 AA081255 zn33d08.r1
Stratagene endothelial cell 937223 Homo sapiens cDNA clone Homo
sapiens 40,271 21-OCT-1996 IMAGE: 549231 5', mRNA sequence.
GB_EST9: C16722 314 C16722 C16722 Clontech human aorta polyA+ mRNA
(#6572) Homo sapiens cDNA clone Homo sapiens 44,013 30-Sep-96
GEN-522C02 5', mRNA sequence. rxa00788 348 GB_PL2: UMU62738 13812
U62738 Ustilago maydis ferrichrome siderophore peptide synthetase
(sid2) gene, complete cds. Ustilago maydis 31,792 30-DEC-1997
GB_PR1: AB012723 40850 AB012723 Homo sapiens gene for kinesin-like
protein, complete cds. Homo sapiens 35,398 8-Jan-99 GB_HTG3:
AC008625 16830 AC008625 Homo sapiens chromosomes 5 clone
CIT978SKB_157D17, *** SEQUENCING Homo sapiens 42,56 3-Aug-99 IN
PROGRESS***, 19 unordered pieces. rxa00795 651 GB_IN2: AC003120
59991 AC003120 Drosophila melanogaster DNA sequence (P1 DS01523
(D34)), complete sequence. Drosophila melanogaster 39,252 17-Jul-98
GB_EST19: AA802212 574 AA802212 GM04027.5prime GM Drosophila
melanogaster ovary BlueScript Drosophila Drosophila melanogaster
37,826 25-Nov-98 melanogaster cDNA clone GM04027 5prime, mRNA
sequence. GB_IN2: AF168467 4652 AF168467 Drosophila melanogaster
dual specificity kinase DYRK2 mRNA,complete cds. Drosophila
melanogaster 36,933 5-Aug-99 rxa00804 567 GB_GSS12: AQ356039 499
AQ356039 CITBI-E1-2535P11.TR CITBI-E1 Homo sapiens genomic clone
2535P11, Homo sapiens 40,569 24-Jan-99 genomic survey sequence.
GB_PR4: AC005037 190508 AC005037 Homo sapiens clone NH0469M07,
complete sequence. Homo sapiens 41,209 14-MAY-1999 GB_HTG5:
AC007272 175463 AC007272 Homo sapiens clone NH0013J08, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 41,209 2-Nov-99 5
unordered pieces. rxa00805 1005 GB_GSS1: CNS00U61 320 AL090583
Arabidopsis thaliana genome survey sequence SP6 end of BAC T6D17 of
TAMU Arabidopsis thaliana 36,364 28-Jun-99 library from strain
Columbia of Arabidopsis thaliana, genomic survey sequence. GB_PL1:
AB026639 63921 AB026639 Arabidopsis thaliana genomic DNA,
chromosome 5, TAC clone: K21L13, complete Arabidopsis thaliana
38,485 07-MAY-1999 sequence. GB_PL1: AB026639 63921 AB026639
Arabidopsis thaliana genomic DNA, chromosome 5, TAC clone: K21L13,
complete Arabidopsis thaliana 35,451 07-MAY-1999 sequence. rxa00808
1581 GB_BA1: MLCB2548 38916 AL023093 Mycobacterium leprae cosmid
B2548. Mycobacterium leprae 50,854 27-Aug-99 GB_BA1: MLCL373 37304
AL035500 Mycobacterium leprae cosmid L373. Mycobacterium leprae
40,295 27-Aug-99 GB_PL2: SCE9781 68302 U18916 Saccharomyces
cerevisiae chromosome V cosmids 9781, 8198, 9115, 9981, and
Saccharomyces cerevislae 37,677 1-Aug-97 lambda clones 3955 and
6052. rxa00812 1182 GB_HTG2: AC006003 114949 AC006003 Homo sapiens
clone DJ0782K24, *** SEQUENCING IN PROGRESS ***, Homo sapiens
35,284 22-Nov-98 16 unordered pieces. GB_HTG2: AC006003 114949
AC006003 Homo sapiens clone DJ0782K24, *** SEQUENCING IN PROGRESS
***, Homo sapiens 35,284 22-Nov-98 16 unordered pieces. GB_GSS9:
AQ090529 323 AQ090529 HS_3007_B1_E09_MR CIT Approved Human Genomic
Sperm Library D Homo sapiens 41,176 26-Aug-98 Homo sapiens genomic
clone Plate = 3007 Col = 17 Row = J, genomic survey sequence.
rxa00814 897 GB_VI: EHVU20824 184427 U20824 Equine herpesvirus 2,
complete genome. Equine herpesvirus 2 35,274 2-Feb-96 GB_VI:
EHVU20824 184427 U20824 Equine herpesvirus 2, complete genome.
Equine herpesvirus 2 38,808 2-Feb-96 GB_PR3: HS466N1 79528 Z97630
Human DNA sequence from clone 466N1 on chromosome Homo sapiens
38,496 23-Nov-99 22q12-13 Contains H1F0(H1 histone family, member
0) gene, 2-amino-3-ketobutyrate-CoA ligase(nuclear gene encoding
mitochondrial protein), GALR3 (galanin receptor) gene, ESTs, GSSs
and CpG islands, complete sequence. rxa00815 696 GB_PR3: CNS01DRL
174928 AL117355 Human chromosome 14 DNA sequence *** IN PROGRESS
*** BAC R-354E14 of Homo sapiens 36,578 26-Nov-99 RPCI-11 library
from chromosome 14 of Homo sapiens (Human), complete sequence.
GB_PR4: AC007283 127361 AC007283 Homo sapiens clone NH0536I18,
complete sequence. Homo sapiens 37,609 28-Sep-99 GB_EST14: AA406984
477 AA406984 MBAFCZ7H08T3 Brugia malayi adult female cDNA
(SAW96MLW-BmAF) Brugia malayi 41,919 01-MAY-1997 Brugia malayi cDNA
clone AFCZ7H08 5', mRNA sequence. rxa00816 420 GB_EST27: AI414036
467 AI414036 ma03e08.x1 Soares mouse p3NMF19.5 Mus musculus cDNA
clone IMAGE: Mus musculus 40,176 9-Feb-99 303494 3' similar to TR:
Q85299 Q85299 HOMOLOGUE OF RETROVIRAL PSEUDOPROTEASE.;, mRNA
sequence. GB_GSS15: AQ642295 501 AQ642295 RPCI93-Dpnll-28G21.TV
RPCI93-Dpnll Trypanosoma brucel genomic clone Trypanosoma brucel
37,54 8-Jul-99 RPCI93-Dpnll-28G21, genomic survey sequence. GB_PL2:
ZMU82481 2750 U82481 Zea mays KI domain interacting kinase 1 (KIK1)
mRNA, complete cds. Zea mays 41,783 1-Jan-98 rax00826 654 GB_PR4:
AC008179 181745 AC008179 Homo sapiens clone NH0576F01, complete
sequence. Homo sapiens 35,736 28-Sep-99 GB_HTG1: AC002413 63369
AC002413 Homo sapiens chromosome X clone bWXD111, *** SEQUENCING IN
Homo sapiens 37,6 12-Aug-97 PROGRESS ***, 2 unordered pieces.
GB_HTG1: AC002413 63369 AC002413 Homo sapiens chromosome X clone
bWXD111, *** SEQUENCING IN Homo sapiens 37,6 12-Aug-97 PROGRESS
***, 2 unordered pieces. rxa00830 846 GB_GSS6: AQ823465 535
AQ823465 HS_3217_A1_D08_T7C CIT Approved Human Genomic Sperm
Library D Homo sapiens 40,417 26-Aug-99 Homo sapiens genomic clone
Plate = 3217 Col = 15 Row = G, genomic survey sequence. GB_GSS6:
AQ825402 381 AQ825402 HS_5498_A1_G01_SP6E RPCI-11 Human Male BAC
Library Homo sapiens 43,068 26-Aug-99 Homo sapiens genomic clone
Plate = 1074 Col = 1 Row = M, genomic survey sequence. GB_HTG1:
HSU242F8 92944 AL022167 Homo sapiens chromosome X clone
LL0XNC01-242F8, *** SEQUENCING IN Homo sapiens 38,321 23-Nov-99
PROGRESS ***, in unordered pieces. rxa00831 rxa00835 1077 GB_EST35:
AI864917 468 AI864917 wj66f11.x1 NCI_CGAP_Lu19 Homo sapiens cDNA
clone IMAGE: Homo sapiens 37,607 30-Aug-99 2407821 3' similar to
WP: F01F1.9 CE01235 VACUOLAR AMINOPEPTIDASE;, mRNA sequence.
GB_EST35: AI864917 468 AI864917 wj66f11.x1 NCI_CGAP_Lu19 Homo
sapiens cDNA clone IMAGE: Homo sapiens 38,444 30-Aug-99 2407821 3'
similar to WP: F01F1.9 CE01235 VACUOLAR AMINOPEPTIDASE;, mRNA
sequence. rxa00836 1816 GB_EST11: AA212728 424 AA212728 mw81g02.r1
Soares mouse NML Mus musculus cDNA clone IMAGE: Mus musculus 40,284
18-Feb-97 677138 5', mRNA sequence. GB_EST26: AI390258 557 AI390258
mw81g02.y1 Soares mouse NML Mus musculus cDNA clone IMAGE: 677138
5', Mus musculus 41,261 2-Feb-99 mRNA sequence. GB_PR3: AC003669
159446 AC003669 Homo sapiens Xp22 BAC GS-594A7 (Genome Systems
Human BAC library) Homo sapiens 34,914 24-MAR-1998 contains Bmx
gene, complete sequence. rxa00840 rxa00841 rxa00846 993 GB_BA1:
U00017 42157 U00017 Mycobacterium leprae cosmid B2126.
Mycobacterium leprae 35,635 01-MAR-1994 GB_BA1: MLCB2533 40245
AL035310 Mycobacterium leprae cosmid B2533. Mycobacterium leprae
38,28 27-Aug-99 GB_RO: AB022047S7 18721 AB022053 Mus musculus gene
for prolyl oligopeptidase, exon 11, 12, 13, 14, 15 and Mus musculus
36,633 20-Aug-99 complete cds. rxa00853 726 GB_PR3: HS531H16 155116
AL031664 Human DNA sequence *** SEQUENCING IN PROGRESS *** from
clone Homo sapiens 41,11 23-Nov-99 531H16, complete sequence.
GB_PR3: HS531H16 155116 AL031664 Human DNA sequence *** SEQUENCING
IN PROGRESS *** from Homo sapiens 37,343 23-Nov-99 clone 531H16,
complete sequence. GB_HTG3: AC010264 81671 AC010264 Homo sapiens
chromosome 5 clone CIT-HSPC_468K18, *** SEQUENCING IN Homo sapiens
38,776 15-Sep-99 PROGRESS ***, 66 unordered pieces. rxa00854 336
GB_IN1: CELM04G7 41778 AF036700 Caenorhabditis elegans cosmid
M04G7. Caenorhabditis elegans 37,349 05-DEC-1997 GB_EST20: AA850405
451 AA850405 EST193172 Normalized rat ovary, Bento Soares Rattus
sp. cDNA clone Rattus sp. 40,789 30-Apr-98 ROVAF27 3' end, mRNA
sequence. GB_HTG2: AF165144 110891 AF165144 Homo sapiens chromosome
8 clone BAC 393A07 map 8q, *** SEQUENCING IN Homo sapiens 34,234
16-Jul-99 PROGRESS ***, inordered pieces. rxa00855 408 GB_HTG2:
AC007173 140775 AC007173 Drosophila melanogaster chromosome 2 clone
BACR01A03 (D538) Drosophila melanogaster 36,341 2-Aug-99 RPCI-98
01.A.3 map 36E-36E strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 36 unordered pieces. GB_NTG2: AC007173 140775 AC007173
Drosophila melanogaster chromosome 2 clone BACR01A03 (D538)
Drosophila melanogaster 36,341 2-Aug-99 RPCI-98 01.A.3 map 36E-36E
strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 36 unordered
pieces. GB_PL2: YSCH8179 44113 U00062 Saccharomyces cerevisiae
chromosome VIII cosmid 8179. Saccharomyces cerevisiae 38,56
4-Sep-97 rxa00861 426 GB_BA1: CGORF4GEN 2398 X95649 C. glutamicum
ORF4 gene. Corynebacterium 100 10-MAR-1998 glutamicum GB_BA1:
SC9A10 9000 AL031260 Streptomyces coelicolor cosmid 9A10.
Streptomyces coelicolor 63,83 11-Aug-98 GB_BA2: AF039028 2475
AF039028 Streptomyces toyocaensis D-ala-D-ala dipeptidase (vanXst)
gene, Streptomyces toyocaensis 61,939 5-Jan-99 complete cds; and
unknown gene. rxa00862 682 GB_PAT: E14520 2001 E14520 DNA encoding
Brevibacterium dihydrodipicolinic acid synthase. Corynebacterium
36,154 28-Jul-99 glutamicum GB_PAT: E12773 2001 E12773 DNA encoding
Brevibacterium dihydrodipicolinic acid reductase. Corynebacterium
36,154 24-Jun-98 glutamicum GB_PAT: E16749 2001 E16749 gDNA
encoding dihydrodipicolinate synthase (DDPS). Corynebacterium
36,154 28-Jul-99 glutamicum rxa00869 1044 GB_EST24: AI166579 645
AI166579 xylem.est.398 Poplar xylem Lambda ZAPII library Populus
balsamifera subsp. Populus balsamifera 39,854 03-DEC-1998
trichocarpa cDNA 5', mRNA sequence. subsp. trichocarpa GB_BA1:
MTCY06H11 38000 Z85982 Mycobacterium tuberculosis H37Rv complete
genome; segment 73/162. Mycobacterium 42,801 17-Jun-98 tuberculosis
GB_EST34: AV153098 283 AV153098 AV153098 Mus musculus hippocampus
C57BL/6J adult Mus musculus cDNA Mus musculus 39,576 7-Jul-99 clone
2900052L10, mRNA sequence. rxa00874 1212 GB_HTG2: AC007885 108561
AC007885 Drosophila melanogaster chromosome 2 clone BACR02G15
(D643) RPCI-98 02.G.15 Drosophila melanogaster 38,276 2-Aug-99 map
60F-60F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 65
unordered pieces. GB_NTG2: AC007582 127205 AC007582 Drosophila
melanogaster chromosome 2 clone BACR17E16 (D642) RPCI-98 17.E.16
Drosophila melanogaster 36,246 2-Aug-99 map 60F-60F strain y; cn bw
sp, *** SEQUENCING IN PROGRESS ***, 81 unordered pieces. GB_HTG2:
AC007885 108561 AC007885 Drosophila melanogaster chromosome 2 clone
BACR02G15 (D643) RPCI-98 02.G.15 Drosophila melanogaster 38,276
2-Aug-99 map 60F-60F strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 65 unordered pieces. rxa00876 1878 GB_EST10: AA144736 479
AA144736 mr72d08.r1 Stratagene mouse testis (#937308) Mus musculus
cDNA clone IMAGE: Mus musculus 41,474 11-Feb-97 602991 5', mRNA
sequence. GB_EST32: AU069076 316 AU069076 AU069076 Rice callus
Oryza sativa cDNA clone C51993_1A, mRNA sequence. Oryza sativa
46,33 7-Jun-99 GB_EST10: AA144736 479 AA144736 mr72d08.r1
Stratagene mouse testis (#937308) Mus musculus cDNA clone IMAGE:
Mus musculus 43,243 11-Feb-97 602991 5', mRNA sequence. rxa00881
501 GB_HTG4: AC010103 192320 AC010103 Homo sapiens chromosome
unknown clone NH0508N21, WORKING DRAFT Homo sapiens 36,62
29-OCT-1999 SEQUENCE, in unordered pieces. GB_HTG4: AC010103 192320
AC010103 Homo sapiens chromosome unknown clone NH0508H21, WORKING
DRAFT Homo sapiens 36,62 29-OCT-1999 SEQUENCE, in unordered pieces.
GB_HTG4: AC010103 192320 AC010103 Homo sapiens chromosome unknown
clone NH0508H21, WORKING DRAFT Homo sapiens 34,28 29-OCT-1999
SEQUENCE, in unordered pieces. rxa00882 801 GB_BA1: MTCY48 35377
Z74020 Mycobacterium tuberculosis H37Rv complete genome; segment
69/162. Mycobacterium 37,927 17-Jun-98 tuberculosis GB_PAT:
AR005211 3453 AR005211 Sequence 1 from patent US 5747651. Unknown.
39,62 04-DEC-1998 GB_PAT: I40600 3453 I40600 Sequence 1 from patent
US 5621090. Unknown. 39,62 13-MAY-1997 rxa00883 642 GB_PR2:
HS217O16 87552 AL031771 Human DNA sequence from clone 217O16 on
chromosome 6q24 Contains GSS, Homo sapiens 33,866 23-Nov-99
complete sequence. GB_PR2: HS217O16 87552 AL031771 Human DNA
sequence from clone 217O16 on chromosome 6q24 Contains GSS, Homo
sapiens 35,479 23-Nov-99
complete sequence. rxa00887 rxa00889 711 GB_BA1: MTCY27 27548
Z95208 Mycobacterium tuberculosis H37Rv complete genome; segment
104/162. Mycobacterium 36,978 17-Jun-98 tuberculosis GB_BA1: U00016
42931 U00016 Mycobacterium leprae cosmid B1937. Mycobacterium
leprae 55,651 01-MAR-1994 GB_PR4: AC007326 102898 AC007326 Homo
sapiens, complete sequence. Homo sapiens 40,205 2-Nov-99 rxa00893
720 GB_PL1: HVCPMII 6225 Y09602 H. vulgare gene encoding serine
carboxypeptidase II, CP-MII. Hordeum vulgare 35,704 10-MAR-1997
GB_EST35: AI814621 441 AI814621 wj75d04.x1 NCI_CGAP_Lu19 Homo
sapiens cDNA clone IMAGE: Homo sapiens 37,788 24-Aug-99 2408647 3'
similar to TR: O00578 O00578 KIAA0167. [1];, mRNA sequence.
GB_EST3: R51723 376 R51723 yg77h06.r1 Soares infant brain 1NIB Homo
sapiens cDNA clone IMAGE: Homo sapiens 41,489 18-MAY-1995 39671 5'
similar to gb: M77016 TROPOMODULIN (HUMAN);, mRNA sequence.
rxa00895 714 GB_HTG3: AC009414 188673 AC009414 Homo sapiens clone
NH0490M08, *** SEQUENCING IN Homo sapiens 36,775 17-Sep-99 PROGRESS
***, 5 unordered pieces. GB_HTG3: AC009414 188673 AC009414 Homo
sapiens clone NH0490M08, *** SEQUENCING IN PROGRESS ***, Homo
sapiens 36,775 17-Sep-99 5 unordered pieces. GB_PR3: HSJ824F16
139330 AL050325 Human DNA sequence from clone 824F16 on chromosome
20, complete sequence. Homo sapiens 37,286 23-Nov-99 rxa00904 815
GB_HTG5: AC006447 141662 AC006447 Mus musculus, *** SEQUENCING IN
PROGRESS ***, 2 unordered pieces. Mus musculus 35,945 17-Nov-99
GB_HTG5: AC011064 233428 AC011064 Drosophila melanogaster
chromosome X clone BACN05G06 (D1107) Drosophila melanogaster 37,783
16-Nov-99 RPCI-98 05.G.6 map 12F-13A strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 220 unordered pieces. GB_HTG6: AC008334
154566 AC008334 Drosophila melanogaster chromosome X clone
BACR08K05 (D885) Drosophila melanogaster 37,783 02-DEC-1999 RPCI-98
08.K.5 map 12F-12F strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 84 unordered pieces. rxa00908 681 GB_GSS12: AQ409791 561
AQ409791 HS_5090_B2_B12_T7A RPCI-11 Human Male BAC Library Homo
sapiens Homo sapiens 39,711 17-MAR-1999 genomic clone Plate = 666
Col = 24 Row = D genomic survey sequence. GB_GSS3: B83773 535
B83773 CpG0110A CpIOWAgDNA1 Cryptosporidium parvum Cryptosporidium
parvum 44,615 06-MAY-1999 genomic, genomic survey sequence.
GB_GSS12: AQ409791 561 AQ409791 HS_5090_B2_B12_T7A RPCI-11 Human
Male BAC Library Homo sapiens Homo sapiens 41,333 17-MAR-1999
genomic clone Plate = 666 Col = 24 Row = D, genomic survey
sequence. rxa00915 753 GB_HTG2: HS1118M15 190466 AL109964 Homo
sapiens chromosome 20 clone RP5-1118M15, *** SEQUENCING IN Homo
sapiens 40,027 30-Nov-99 PROGRESS ***, inunordered pieces. GB_HTG2:
HS1057B20 204291 AL109823 Homo sapiens chromosome 20 clone
RP5-1057B20 map q11.21-12, Homo sapiens 38,535 30-Nov-99 ***
SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: HS1118M15
190466 AL109964 Homo sapiens chromosome 20 clone RP5-1118M15, Homo
sapiens 40,027 30-Nov-99 *** SEQUENCING IN PROGRESS ***, in
unordered pieces. rxa00916 3714 GB_EST28: AI543268 568 AI543268
SD09973.5prime SD Drosophila melanogaster Schnelder L2 cell culture
pOT2 Drosophila melanogaster 40,426 22-MAR-1999 Drosophila
melanogaster cDNA clone SD09973 5prime, mRNA sequence. GB_IN2:
AC004301 68620 AC004301 Drosophila melanogaster DNA sequence (P1
DS07134 (D192)), complete sequence. Drosophila melanogaster 37,696
29-MAY-1998 GB_EST37: AI994315 524 AI994315 701502677 A. thaliana,
Ohio State clone set Arabidopsis thaliana cDNA Arabidopsis thaliana
40,076 8-Sep-99 clone 701502677, mRNA sequence. rxa00917 2802
GB_BA1: SYCSLRB 146271 D64000 Synechocystis sp. PCC6803 complete
genome, 19/27, 2392729-2538999. Synechocystis sp. 38,447 13-Feb-99
GB_HTG1: CEY39E4_2 110000 Z94158 Caenorhabditis elegans chromosome
III clone Y39E4. Caenorhabditis elegans 38,218 Z94158 ***
SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY39E4_2
110000 Z94158 Caenorhabditis elegans chromosome III clone Y39E4,
Caenorhabditis elegans 38,218 Z94158 *** SEQUENCING IN PROGRESS
***, in unordered pieces. rxa00921 rxa00926 486 GB_OM: SSU75316
5996 U75316 Sus scrofa beta-myosin heavy chain mRNA, complete cds.
Sus scrofa 38,958 03-DEC-1996 GB_EST21: AA970971 371 AA970971
op10b11.s1 NCI_CGAP_Kid6 Homo sapiens cDNA clone IMAGE: 1575261 3',
Homo sapiens 40,841 13-Apr-99 mRNA sequence. GB_OM: SSU75316 5996
U75316 Sus scrofa beta-myosin heavy chain mRNA, complete cds. Sus
scrofa 38,578 03-DEC-1996 rxa00930 876 GB_BA1: MTCI270A 1670 Z98045
Mycobacterium tuberculosis H37Rv complete genome; segment 116/162.
Mycobacterium 37,927 17-Jun-98 tuberculosis GB_BA1: U00011 40429
U00011 Mycobacterium leprae cosmid B1177. Mycobacterium leprae
38,623 01-MAR-1994 GB_RO: S58745 817 S58745 thyrotroph embryonic
factor = leucine zipper transcription factor [rats, Rattus sp.
41,483 07-MAY-1993 pituitary, mRNA, 817 nt]. rxa00932 597 GB_PR4:
AC009509 192690 AC009509 Homo sapiens 12p11-37.2-54.4 BAC
RP11-1060J15 (Roswell Park Cancer Homo sapiens 38,776 01-DEC-1999
Institute Human BAC Library) complete sequence. GB_PR3: AC004072
170658 AC004072 Human Chromosome X clone bWXD342, complete
sequence. Homo sapiens 35 08-MAR-1998 GB_PR4: AC004617 176552
AC004617 Homo sapiens chromosome Y, clone 264, M, 20, complete
sequence. Homo sapiens 35,702 13-OCT-1999 rxa00933 585 GB PL1:
MGNGAGPOLI 5638 L35053 Transposon MAGGY gag and pol gene
homologues, partial cds's. Magnaporthe grisea 40,283 4-Aug-94 GB
PL1: MGNGAGPOLI 5638 L35053 Transposon MAGGY gag and pol gene
homologues, partial cds's. Magnaporthe grisea 37,739 4-Aug-94
rxa00940 519 GB_PR2: HS179N16 172048 Z95152 Homo sapiens DNA
sequence from PAC 179N16 on chromosome 6p21.1-21.33. Homo sapiens
38,262 23-Nov-99 Contains the SAPK4 (MAPK p38delta) gene, and the
alternatively spliced SAPK2 gene coding for CSaids binding protein
CSBP2 and a MAPK p38beta LIKE protein. Contains ESTs, STSs and two
predicted CpG islands, complete sequence. GB_EST26: AU001018 304
AU001018 AU001018 Bombyx mori p50(Daizo) Bombyx mori cDNA clone
fbf0932f, Bombyx mori 45,745 15-Jan-99 mRNA sequence. GB_EST26:
AU001019 304 AU001019 AU001019 Bombyx mori p50(Daizo) Bombyx mori
cDNA clone fbf0934f, Bombyx mori 45,745 15-Jan-99 mRNA sequence.
rxa00943 1035 GB_BA2: AF079317 184457 AF079317 Sphingomonas
aromaticivorans plasmid pNL1, complete plasmid sequence.
Sphingomonas 38,151 12-Jan-99 aromaticivorans GB_HTG3: AC008329
114408 AC008329 Drosophila melanogaster chromosome 2 clone
BACR31D05 (D861) RPCI-98 31.D.5 Drosophila melanogaster 34,317
17-Aug-99 map 28C-28D strain y; cn bw sp, *** SEQUENCING IN
PROGRESS ***, 105 unordered pieces. GB_HTG3: AC008329 114408
AC008329 Drosophila melanogaster chromosome 2 clone BACR31D05
(D861) RPCI-98 31.D.5 Drosophila melanogaster 34,317 17-Aug-99 map
28C-28D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 105
unordered pieces. rxa00946 897 GB_BA1: MTV008 63033 AL021246
Mycobacterium tuberculosis H37Rv complete genome; segment 108/162.
Mycobacterium 36,045 17-Jun-98 tuberculosis GB_GSS14: AQ571765 526
AQ571765 HS_2094_A2_B09_MR CIT Approved Human Genomic Sperm Library
D Homo sapiens 38,021 1-Jun-99 Homo sapiens genomic clone Plate =
2094 Col = 18 Row = C, genomic survey sequence. GB_RO: RRFE65G 2464
X60468 R. rattus FE65 gene for adaptor protein interacting with the
beta-amyloid precursor Rattus rattus 38,417 1-Feb-96 protein
intracellular domain. rxa00949 771 GB_VI: PPCCGAAA 5366 M26281
Hamster papovavirus complete genome. Hamster papovavirus 36,579
22-MAY-1995 GB_VI: HAPVXX 5366 X02449 Hamster papovavirus (HapV)
genome. Hamster papovavirus 36,579 22-OCT-1999 GB_BA2: AE000878
15432 AE000878 Methanobacterium thermoautotrophicum from bases
976801 to 992232 Methanobacterium 36,856 15-Nov-97 (section 84 of
148) of the complete genome. thermoautotrophicum rxa00959 579
GB_BA1: CGMTRAR 951 X75083 C. glutamicum mtrA gene locus with
5-methyltryptophan resistance. Corynebacterium 99,133 18-Aug-94
glutamicum GB_BA1: CGMTRA 587 X75084 C. glutamicum sequence
corresponding to mtrA locus. Corynebacterium 99,216 18-Aug-94
glutamicum GB_BA1: BLTRP 7725 X04960 Brevibacterium lactofermentum
tryptophan operon. Corynebacterium 96,8 10-Feb-99 glutamicum
rxa00963 960 GB_EST15: AA484511 504 AA484511 nf08f07.s1
NCI_CGAP_LI1 Homo sapiens cDNA clone IMAGE: 913189 similar Homo
sapiens 43,75 18-Aug-97 to gb: Y00764 UBIQUINOL-CYTOCHROME C
REDUCTASE 11 KD PROTEIN (HUMAN);, mRNA sequence. GB_EST20: AA894481
544 AA894481 nw76b10.s1 NCI_CGAP_Pr12 Homo sapiens cDNA clone
IMAGE: 1252507 Homo sapiens 37,5 6-Apr-98 similar to gb: Y00764
UBIQUINOL-CYTOCHROME C REDUCTASE 11 KD PROTEIN (HUMAN);, mRNA
sequence. GB_EST15: AA526497 582 AA526497 ni96d07.s1 NCI_CGAP_Pr21
Homo sapiens cDNA clone IMAGE: 984685 3' similar Homo sapiens
38,554 5-Aug-97 to gb: Y00764 UBIQUINOL-CYTOCHROME C REDUCTASE 11
KD PROTEIN (HUMAN);, mRNA sequence. rxa00969 1458 GB_BA1: CGHOMTHR
3685 Y00546 Corynebacterium glutamicum hom-thrB genes for
homoserine dehydrogenase and Corynebacterium 99,588 12-Sep-93
homoserine kinase. glutamicum GB_PAT: I09077 3685 I09077 Sequence 1
from Patent WO 8809819. Unknown. 99,246 02-DEC-1994 GB_BA1: BLTHRA
1483 Y00476 B. lactofermentum thr A gene. Corynebacterium 99,378
05-MAY-1993 glutamicum rxa00971 341 GB_BA1: CGHOMTHR 3685 Y00546
Corynebacterium glutamicum hom-thrB genes for homoserine
dehydrogenase and Corynebacterium 35,435 12-Sep-93 homoserine
kinase. glutamicum GB_PAT: I09077 3685 I09077 Sequence 1 from
Patent WO 8809819. Unknown. 35,435 02-DEC-1994 GB_BA1: BLTHRB 1139
Y00140 Brevibacterium lactofermentum thrB gene for homoserine
kinase. Corynebacterium 40,964 12-Sep-93 glutamicum rxa00973 726
GB_BA1: CGHOMTHR 3685 Y00546 Corynebacterium glutamicum hom-thrB
genes for homoserine dehydrogenase and Corynebacterium 41,797
12-Sep-93 homoserine kinase. glutamicum GB_PAT: I09077 3685 I09077
Sequence 1 from Patent WO 8809819. Unknown. 41,797 02-DEC-1994
GB_IN2: AC006574 127035 AC006574 Drosophila melanogaster,
chromosome 2R, region 39A3-39B1, P1 clones Drosophila melanogaster
37,355 16-Feb-99 DS02919 and DS05130, complete sequence. rxa00978
738 GB_PR2: HSAC000372 41730 AC000372 Human cosmid g1980a186,
complete sequence. Homo sapiens 34,674 12-MAR-1997 GB_PR3: AC005503
40998 AC005503 Homo sapiens clone UWGC: g5129s003 from 7q31,
complete sequence. Homo sapiens 34,674 20-Aug-98 GB_PR2: HSAC000372
41730 AC000372 Human cosmid g1980a186, complete sequence. Homo
sapiens 38,881 12-MAR-1997 rxa00986 465 GB_GSS10: AQ258013 761
AQ258013 nbxb0019H05f CUGI Rice BAC Library Oryza sativa genomic
clone nbxb0019h05f, Oryza sativa 31,533 23-OCT-1998 genomic survey
sequence. GB_PR3: HS83L6 61187 Z99130 Human DNA sequence from PAC
83L6 on chromosome Xp11.1-11.22. Contains Homo sapiens 38,395
23-Nov-99 ZXDA (ZFPA) zinc finger gene, ESTs and STSs, complete
sequence. GB_PR3: HS598A24 96558 AL031115 Human DNA sequence from
clone 598A24 on chromosome Xp11.1-11.23 Contains Homo sapiens
37,333 23-Nov-99 zinc finger X-linked proteins ZXDA, ZXDB, ESTs and
STS, complete sequence. rxa00987 588 GB_HTG1: HS24A17 2000 AL035452
Homo sapiens chromosome X clone RP6-24A17, *** SEQUENCING IN Homo
sapiens 38,821 23-Nov-99 PROGRESS ***, in unordered pieces.
GB_HTG1: HS24A17 2000 AL035452 Homo sapiens chromosome X clone
RP6-24A17, *** SEQUENCING IN Homo sapiens 38,821 23-Nov-99 PROGRESS
***, In unordered pieces. GB_PR2: HS1156N12 146360 AL009047 Human
DNA sequence from clone 1156N12 on chromosome X. Contains an STS
Homo sapiens 38,821 23-Nov-99 and GSSs complete sequence. rxa00988
546 GB_IN1: CELZC328 30350 AF000194 Caenorhabditis elegans cosmid
ZC328. Caenorhabditis elegans 36,122 23-Apr-97 GB_IN1: CELZC328
30350 AF000194 Caenorhabditis elegans cosmid ZC328. Caenorhabditis
elegans 37,959 23-Apr-97 rxa01005 969 GB_BA1: FVBPOAD2A 45519
D26094 Flavobacterium sp. plasmid pOAD2 DNA, whole sequence.
Flavobacterium sp. 37,998 6-Feb-99 GB_GSS1: CNS00UGV 472 AL090973
Arabidopsis thaliana genome survey sequence SP6 end of BAC T6P9 of
TAMU Arabidopsis thaliana 39,024 28-Jun-99 library from strain
Columbia of Arabidopsis thaliana, genomic survey sequence. GB_GSS1:
CNS00S69 512 AL087999 Arabidopsis thaliana genome survey sequence
SP6 end of BAC T1C4 of TAMU Arabidopsis thaliana 35,938 28-Jun-99
library from strain Columbia of Arabidopsis thaliana, genomic
survey sequence. rxa01007 rxa01008 rxa01011 1356 GB_EST38: AW039107
598 AW039107 EST281080 tomato mixed elicitor, BTI Lycopersicon
esculentum cDNA clone Lycopersicon esculentum 39,724 18-OCT-1999
cLET12F19, mRNA sequence. GB_BA1: MTY13E12 43401 Z95390
Mycobacterium tuberculosis H37Rv complete genome; segment 147/162.
Mycobacterium 38,618 17-Jun-98 tuberculosis GB_BA1: MBU15140 2136
U15140 Mycobacterium bovis ribosomal proteins IF-1 (infA), L36
(rpmJ), S13 (rpsM) and Mycobacterium bovis 37,07 28-OCT-1996 S11
(rpsK) genes, complete cds, and S4 (rpsD) gene, partial cds.
rxa01016 771 GB_BA1: CGBPHI16 962 Y12472 C. glutamicum DNA,
attachment site bacteriophage Phi-16. Corynebacterium 45,098
05-MAR-1999 glutamicum GB_BA1: CGBPHI16 962 Y12472 C. glutamicum
DNA, attachment site bacteriophage Phi-16. Corynebacterium 37,251
05-MAR-1999 glutamicum rxa01017 732 GB_BA1: CGBPHI16 962 Y12472 C.
glutamicum DNA, attachment site bacteriophage Phi-16.
Corynebacterium 39,245 05-MAR-1999 glutamicum GB_BA2: AF099014 2500
AF099014 Streptomyces coelicolor strain A3(2) transposase (tnpA)
and Fe-containing Streptomyces coelicolor 38,036 1-Jun-99
superoxide dismutase I (sodF1) genes, complete cds. GB_HTG3:
AC009249 119461 AC009249 Drosophila melanogaster chromosome 3 clone
BACR02M06 (D1003) Drosophila melanogaster 37,853 27-Aug-99 RPCI-98
02.M.6 map 98B-98B strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 97 unordered pieces. rxa01021 622 GB_BA2: U39718 8603 U39718
Mycoplasma genitalium section 40 of 51 of the complete genome.
Mycoplasma genitalium 39,348 5-Nov-98 GB_GSS3: B46221 457 B46221
HS-1063-A2-D06-MR.abi CIT Human Genomic Sperm Library C Homo
sapiens Homo sapiens 39,933 21-OCT-1997 genomic clone Plate = CT
796 Col = 12 Row = G. genomic survey sequence. GB_OV: AF035529 848
AF035529 Xenopus laevis Smad6 mRNA, partial cds. Xenopus laevis
37,203 1-Jan-98 rxa01023 1101 GB_HTG2: HSJ435K13 151301 AL109941
Homo sapiens chromosome 6 clone RP3-435K13 map q14.1-16.1, Homo
sapiens 34,405 03-DEC-1999 *** SEQUENCING IN PROGRESS ***, in
unordered pieces. GB_HTG2: HSJ435K13 151301 AL109941 Homo sapiens
chromosome 6 clone RP3-435K13 map q14.1-16.1, Homo sapiens 34,405
03-DEC-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces.
GB_BA1: RCU57682 86896 U57682 Rhodobacter capsulatus cosmids
143-147, complete sequence. Rhodobacter capsulatus 39,022 7-Feb-97
rxa01028 2172 GB_IN1: CBU55260 2518 U55260 Caenorhabditis briggsae
beta tubulin (mec-7) gene, complete cds. Caenorhabditis briggasae
39,467 5-Jun-96 GB_HTG1: CEY1A5 196643 AL008872 Caenorhabditis
elegans chromosome III clone Y1A5, *** SEQUENCING IN Caenorhabditis
elegans 38,168 9-Nov-97 PROGRESS ***, in unordered pieces. GB_HTG1:
CEY1A5 196643 AL008872 Caenorhabditis elegans chromosome III clone
Y1A5, *** SEQUENCING Caenorhabditis elegans 38,168 9-Nov-97 IN
PROGRESS ***, in unordered pieces. rxa01029 612 GB_PR3: HS466P17
149963 AL023806 Human DNA sequence from clone 466P17 on chromosome
6q24. Contains a putative Homo sapiens 38,33 23-Nov-99 novel gene,
the 5' part of the EPM2A (Laforin) gene, ESTs. STSs, GSSs, genomic
marker D6S1703 and D6S1443, a putative CpG island and a ca repeat
polymorphism, complete sequence. GB_PR3: HS466P17 149963 AL023806
Human DNA sequence from clone 466P17 on chromosome 6q24. Contains a
Homo sapiens 39,262 23-Nov-99 putative novel gene, the 5' part of
the EPM2A (Laforin) gene, ESTs. STSs, GSSs, genomic marker D6S1703
and D6S1443, a putative CpG island and a ca repeat polymorphism,
complete sequence. GB_RO: D78344 59641 D78344 Mouse DNA for Ig
gamma-chains, partial cds. Mus musculus 35,472 5-Feb-99 rxa01031
789 GB_PR4: AC006948 168558 AC006948 Homo sapiens chromosome 17,
clone hRPK.334_M_10, complete sequence. Homo sapiens 44,005
27-Apr-99 GB_PL2: AC011665 101845 AC011665 Arabidopsis thaliana
chromosome I BAC T6L1 genomic sequence, complete Arabidopsis
thaliana 38,17 11-Nov-99 sequence. GB_RO: MMU19724 5523 U19724 Mus
musculus MMTV integration locus. aromatase gene, 3'UTR. Mus
musculus 35,256 17-Feb-96 rxa01032 498 GB_EST9: AA118349 576
AA118349 ml56b06.r1 Stratagene mouse testis (#937308) Mus musculus
cDNA clone IMAGE: Mus musculus 43,056 19-Nov-96 515987 5' similar
to gb: L04852 Mouse (MOUSE);, mRNA sequence. GB_EST9: AA118349 576
AA118349 ml56b06.r1 Stratagene mouse testis (#937308) Mus musculus
cDNA clone IMAGE: Mus musculus 42,273 19-Nov-96 515987 5' similar
to gb: L04852 Mouse (MOUSE);, mRNA sequence. rxa01033 459 GB_GSS13:
AQ434868 520 AQ434868 HS_5117_B1_D07_SP6E RPCI-11 Human Male BAC
Library Homo sapiens Homo sapiens 38,608 31-MAR-1999 genomic clone
Plate = 693 Col = 13 Row = H, genomic survey sequence. GB_HTG2:
HSDJ794I6 137124 AL109976 Homo sapiens chromosome 20 clone
RP4-794I6, *** SEQUENCING IN Homo sapiens 28,929 27-Nov-99 PROGRESS
***, in unordered pieces. GB_HTG2: HSDJ794I6 137124 AL109976 Homo
sapiens chromosome 20 clone RP4-794I6, *** SEQUENCING IN Homo
sapiens 28,929 27-Nov-99 PROGRESS ***, in unordered pieces.
rxa01034 477 GB_PL2: ATT29H11 87011 AL049659 Arabidopsis thaliana
DNA chromosome 3, BAC clone T29H11. Arabidopsis thaliana 32,495
9-Jun-99 GB_PL2: ATT29H11 87011 AL049659 Arabidopsis thaliana DNA
chromosome 3, BAC clone T29H11. Arabidopsis thaliana 40,042
9-Jun-99 GB_EST25: AU045739 436 AU045739 AU045739 Mouse
sixteen-cell-embryo cDNA Mus musculus cDNA clone Mus musculus
35,435 09-DEC-1998 J0940F02 3', mRNA sequence. rxa01035 729
GB_GSS1: CNS00QD8 526 AL085658 Arabidopsis thaliana genome survey
sequence SP6 end of BAC F11C22 of IGF Arabidopsis thaliana 36,466
28-Jun-99 library from strain Columbia of Arabidopsis thaliana,
genomic survey sequence. GB_GSS13: AQ447948 515 AQ447948
mgxb0015A01r CUGI Rice Blast BAC Library Magnaporthe grisea genomic
Magnaporthe grisea 45,833 8-Apr-99 clone mgxb0015A01r, genomic
survey sequence. GB_GSS1: CNS00QD8 526 AL085658 Arabidopsis
thaliana genome survey sequence SP6 end of BAC F11C22 of IGF
library Arabidopsis thaliana 37,5 28-Jun-99 from strain Columbia of
Arabidopsis thaliana, genomic survey sequence. rxa01036 576
GB_HTG2: AC004846 143577 AC004846 Homo sapiens clone DJ0647C14, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 38,137 12-Jun-98 21
unordered pieces. GB_EST19: AA804532 427 AA804532 ns28c05.s1
NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE: Homo sapiens 33,582
18-Feb-98 1184936 3' similar to contains element MER40 repetitive
element;, mRNA sequence. GB_HTG2: AC006342 201618 AC006342 Homo
sapiens clone DJ0054D12, *** SEQUENCING IN PROGRESS ***, Homo
sapiens 38,137 11-Jan-99 3 unordered pieces. rxa01037 651 GB_PR4:
AC004812 138532 AC004812 Homo sapiens PAC clone 267D11 from 12,
complete sequence. Homo sapiens 39,75 05-DEC-1998 GB_HTG2: AC006342
201618 AC006342 Homo sapiens clone DJ0054D12, *** SEQUENCING IN
PROGRESS ***, Homo sapiens 41,214 11-Jan-99 3 unordered pieces.
GB_HTG2: AC004846 143577 AC004846 Homo sapiens clone DJ0647C14, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 41,214 12-Jun-98 21
unordered pieces. rxa01038 rxa01039 699 GB_PR4: HUAC004682 189134
AC004682 Homo sapiens Chromosome 16 BAC clone CIT987SK-A-259H10,
complete sequence. Homo sapiens 36,192 23-Nov-99 GB_HTG2: HS500L14
164856 AL023583 Homo sapiens chromosome 6 clone RP3-500L14 map
p23-24.3, Homo sapiens 34,632 30-Nov-99 *** SEQUENCING IN PROGRESS
***, in unordered pieces. GB_HTG2: HS500L14 164856 AL023583 Homo
sapiens chromosome 6 clone RP3-500L14 map p23-24.3, Homo sapiens
34,632 30-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered
pieces. rxa01040 1026 GB_EST24: AI193549 479 AI193549 qe70e06.x1
Soares_fetal_lung_NbHL19W Homo sapiens cDNA clone IMAGE: Homo
sapiens 40,126 29-OCT-1998 1744354 3', mRNA sequence. GB_PR2:
HSU38545 3609 U38545 Human ARF-activated
phosphatidytcholine-specific phospholipase D1a (hPLD1) Homo sapiens
38,652 10-MAR-1997 mRNA, complete cds. GB_PR2: AC002481 28244
AC002481 Human cosmid clone LUCA12 from 3p21.3, complete sequence,
Homo sapiens 39,643 21-Aug-97 rxa01041 276 GB_HTG6: AC007957 212658
AC007957 Homo sapiens, *** SEQUENCING IN PROGRESS ***, 2 ordered
pieces. Homo sapiens 40,809 26-Nov-99 GB_PR2: AP000552 157086
AP000552 Homo sapiens genomic DNA. chromosome 22q11.2, BCRL2
region, clone: Homo sapiens 40,809 01-OCT-1999 KB1183D5. GB_PR3:
HS57A13 169693 Z83848 Human DNA sequence from PAC 57A13 between
markers DXS6791 and Homo sapiens 37,647 23-Nov-99 DXS8038 on
chromosome X contains glutamate receptor subunit GluRC, ESTs, STS
and polymorphic CA repeat. rxa01042 1401 GB_BA1: MTCY10G2 38970
Z92539 Mycobacterium tuberculosis H37Rv complete genome; segment
47/162. Mycobacterium 36,023 17-Jun-98 tuberculosis GB_BA1:
MTCY10G2 38970 Z92539 Mycobacterium tuberculosis H37Rv complete
genome; segment 47/162. Mycobacterium 37,01 17-Jun-98 tuberculosis
GB_EST29: AI551042 538 AI551042 vx33d11.x1 Stratagene mouse lung
937302 Mus musculus cDNA clone IMAGE: Mus musculus 38,806
23-MAR-1999 1277013 3', mRNA sequence. rxa01043 696 GB_BA1:
AF006658 2500 AF006658 Bacteroides fragilis beta-glucosidase gene,
complete cds. Bacteroides fragilis 39,156 12-Jul-97 GB_BA1:
MLB1790G 37617 Z14314 M. leprae genes rplL, rpoB, rpoC, end, rpsL,
rpsG, efg, tuf, rpsJ, rplC for ribosomal Mycobacterium leprae 39,97
11-Feb-93 protein L7, RNA polymerase beta subunit, RNA polymerase
beta' subunit, endonuclease. ribosomal protein S7, ribosomal
protein S12, elongation factor G, elongation factor Tu, ribosomal
protein S10, ribosomal protein L3 and mkl gene. GB_BA1: AF006658
2500 AF006658 Bacteroides fragilis beta-glucosidase gene, complete
cds. Bacteroides fragilis 36,472 12-Jul-97 rxa01044 1380 GB_HTG6:
AC010998 144338 AC010998 Homo sapiens clone RP11-95l16, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 37,63 08-DEC-1999 17
unordered pieces. GB_HTG6: AC010998 144338 AC010998 Homo sapiens
clone RP11-95l16, *** SEQUENCING IN PROGRESS ***, Homo sapiens
37,864 08-DEC-1999 17 unordered pieces. GB_BA2: AE000939 10599
AE000939 Methanobacterium thermoautotrophicum from bases 1698671 to
1709269 Methanobacterium 34,48 15-Nov-97 (section 145 of 148) of
the complete genome. thermoautotrophicum rxa01045 1947 GB_VI:
FCVF6A 8440 M18247 Feline leukemia virus, subgroup A (FeLV-FAIDS),
complete nucleotide sequence. Feline leukemia virus 37,617
29-MAR-1998 GB_OM: CATFLVPOL 3639 L06140 Felis catus endogenous
FeLV proviral polyprotein (protease (PRO), reverse Felis catus
41,966 21-Aug-95 transcriptase (RT), integrase/endonuclease (INT))
and pol pseudogene, 3' end. GB_VI: CEAVCG 9189 M33677 Caprine
arthritis encephalitis virus, complete proviral genome. Caprine
arthritis- 36,297 04-MAR-1996 encephalitis virus rxa01046 1902
GB_HTG3: AC008423 177734 AC008423 Homo sapiens chromosome 5 clone
CIT-HSPC_298N6, *** SEQUENCING IN Homo sapiens 38,72 3-Aug-99
PROGRESS ***, 56 unordered pieces. GB_HTG3: AC008423 177734
AC008423 Homo sapiens chromosome 5 clone CIT-HSPC_298N6, ***
SEQUENCING IN Homo sapiens 38,72 3-Aug-99 PROGRESS ***, 56
unordered pieces. GB_HTG3: AC008423 177734 AC008423 Homo sapiens
chromosome 5 clone CIT-HSPC_298N6, *** SEQUENCING IN Homo sapiens
35,882 3-Aug-99 PROGRESS ***, 56 unordered pieces. rxa01047 597
GB_EST20: AA842685 510 AA842685 MBAFCZ9C11T3 Brugia malayi adult
female cDNA (SAW96MLW-BmAF) Brugia malayl 37,965 02-MAR-1998 Brugia
malayl cDNA clone AFCZ9C11 5', mRNA sequence. GB_EST20: AA842685
510 AA842685 MBAFCZ9C11T3 Brugia malayi adult female cDNA
(SAW96MLW-BmAF) Brugia malayi 41,697 02-MAR-1998 Brugia malayi cDNA
clone AFCZ9C11 5'. mRNA sequence. GB_EST20: AA842685 510 AA842685
MBAFCZ9C11T3 Brugia malayi adult female cDNA (SAW96MLW-BmAF) Brugia
malayi 41,697 02-MAR-1998 Brugia malayi cDNA clone AFCZ9C11 5'.
mRNA sequence. rxa01058 444 GB_GSS9: AQ160800 745 AQ160800
nbxb0006C07r CUGI Rice BAC Library Oryza sativa genomic clone Oryza
sativa 38,242 12-Sep-98 nbxb0006C07r, genomic surveysequence.
GB_GSS3: B10162 1102 B10162 F11B10-Sp6 IGF Arabidopsis thaliana
genomic clone F11B10, Arabidopsis thaliana 42,263 14-MAY-1997
genomic survey sequence. GB_BA1: AB032799 9077 AB032799
Chromobacterium violaceum violacein biosynthetic gene
Chromobacterium 34,475 02-OCT-1999 cluster (vioA, vio B, vio C, vio
D), complete cds. violaceum rxa01063 453 GB_GSS4: AQ707752 510
AQ707752 HS_5560_A2_G07_T7A RPCI-11 Human Male Homo sapiens 36,932
7-Jul-99 BAC Library Homo sapiens genomic clone Plate = 1136 Col =
14 Row = M, genomic survey sequence. GB_GSS4: AQ707752 510 AQ707752
HS_5560_A2_G07_T7A RPCI-11 Human Male BAC Library Homo sapiens
35,885 7-Jul-99 Homo sapiens genomic clone Plate = 1136 Col = 14
Row = M, genomic survey sequence. rxa01066 849 GB_BA2: U32709 10010
U32709 Haemophilus influenzae Rd section 24 of 163 of the complete
genome. Haemophilus influenzae Rd 36,158 29-MAY-1998 GB_RO:
AB009615 1515 AB009615 Mus musculus mRNA for type II
phosphatidylinositolphosphate kinase-alpha, Mus musculus 37,861
13-Feb-99 complete cds. GB_RO: AB032899 1914 AB032899 Rattus
norvegicus PIPK2 alpha mRNA for phosphatidylinositol 5-phosphate
Rattus norvegicus 38,48 07-OCT-1999 4-kinase alpha, complete cds.
rxa01068 1194 GB_HTG4: AC006091 176878 AC006091 Drosophila
melanogaster chromosome 3 clone BACR48G05 (D475) Drosophila
melanogaster 35,539 27-OCT-1999 RPCI-98 48.G.5 map 91F1-91F13
strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 4 unordered
pieces. GB_HTG4: AC006091 176878 AC006091 Drosophila melanogaster
chromosome 3 clone BACR48G05 (D475) RPCI-98 Drosophila melanogaster
35,539 27-OCT-1999
48.G.5 map 91F1-91F13 strain y; cn bw sp, *** SEQUENCING IN
PROGRESS ***, 4 unordered pieces. GB_HTG2: AC008141 100729 AC008141
Drosophila melanogaster chromosome 3 clone BACR17F04 (D988) RPCI-98
Drosophila melanogaster 34,415 2-Aug-99 17.F.4 map 91F-91F strain
y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 69 unordered pieces.
rxa01069 837 GB_EST15: AA531901 524 AA531901 TgESTzz32g09.r1 TgME49
invivo Bradyzoite cDNA size selected Toxoplasma gondii 43,005
22-Jul-97 Toxoplasma gondii cDNA clone tgzz32g09.r1 5', mRNA
sequence. GB_EST15: AA520183 527 AA520183 TgESTzz39d01.s1 TgME49
invivo Bradyzoite cDNA size selected Toxoplasma Toxoplasma gondii
40,664 16-Jul-97 gondii cDNA clone tgzz39d01.s1 3', mRNA sequence.
GB_HTG6: AC010846 187611 AC010846 Drosophila melanogaster
chromosome X clone BACR13G13 (D894) RPCI-98 Drosophila melanogaster
36,679 03-DEC-1999 13.G.13 map 14B-14C strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 97 unordered pieces. rxa01071 2187
GB_EST20: AA880319 450 AA880319 vx39h01.r1 Stratagene mouse lung
937302 Mus musculus cDNA Mus musculus 40,724 26-MAR-1998 clone
IMAGE: 1277617 5', mRNA sequence. GB_GSS14: AQ558382 435 AQ558382
HS_2068_B1_F06_T7C CIT Approved Human Homo sapiens 36,882
29-MAY-1999 Genomic Sperm Library D Homo sapiens genomic clone
Plate = 2068 Col = 11 Row = L, genomic survey sequence. GB_GSS15:
AQ600385 483 AQ600385 HS_5357_B2_C05_SP6E RPCI-11 Human Male Homo
sapiens 40,476 10-Jun-99 BAC Library Homo sapiens genomic clone
Plate = 933 Col = 10 Row = F, genomic survey sequence. rxa01074 828
GB_BA1: PSEHEDDH 3060 M74256 Pseudomonas aeruginosa Pseudomonas
aeruginosa 39,657 30-Nov-93 6-phosphogluconate dehydratase (edd)
gene, and glyceraldehyde-3- phosphate dehydrogenase (gap) gene,
complete cds. GB_BA1: CGL007732 4460 AJ007732 Corynebacterium
glutamicum 3' ppc gene, secG gene, amt gene, Corynebacterium 39,168
7-Jan-99 ocd gene and 5' soxA gene. glutamicum GB_EST9: AA066016
406 AA066016 ml52f12.r1 Stratagene mouse testis (#937308) Mus
musculus cDNA Mus musculus 43,382 3-Feb-97 clone IMAGE: 515663 5',
mRNA sequence. rxa01075 534 GB_EST21: AA986543 445 AA986543
ue14f08.x1 Sugano mouse embryo mewa Mus musculus cDNA Mus musculus
31,236 28-MAY-1998 clone IMAGE: 1480359 3', mRNA sequence.
GB_EST22: AI035794 509 AI035794 ue17d01.y1 Sugano mouse embryo mewa
Mus musculus cDNA clone IMAGE: Mus musculus 42,264 26-Jun-98
1480609 5', mRNA sequence. GB_EST22: AI006506 384 AI006506
ue14f08.y1 Sugano mouse embryo mewa Mus musculus cDNA clone IMAGE:
Mus musculus 46,637 12-Jun-98 1480359 5', mRNA sequence. rxa01076
1143 GB_HTG2: AC007741 162450 AC007741 Homo sapiens clone
NH0340F16, *** SEQUENCING IN Homo sapiens 38,209 5-Jun-99 PROGRESS
***, 3 unordered pieces. GB_HTG2: AC007741 162450 AC007741 Homo
sapiens clone NH0340F16, *** SEQUENCING IN PROGRESS ***, Homo
sapiens 38,209 5-Jun-99 3 unordered pieces. GB_EST33: AV072325 317
AV072325 AV072325 Mus musculus stomach C57BL/6J adult Mus musculus
Mus musculus 48,485 24-Jun-99 cDNA clone 2200003E03, mRNA sequence.
rxa01078 957 GB_BA2: RCPHSYNG 45959 Z11165 R. capsulatus complete
photosynthesis gene cluster. Rhodobacter capsulatus 36,603 2-Sep-99
GB_BA2: RCPHSYNG 45959 Z11165 R. capsulatus complete photosynthesis
gene cluster. Rhodobacter capsulatus 37,989 2-Sep-99 GB_PR4:
AF073931 7898 AF073931 Homo sapiens low-voltage activated calcium
channel alpha 1H mRNA, complete cds. Homo sapiens 37,953
04-MAR-1999 rxa01083 399 GB_BA2: AF112535 4363 AF112535
Corynebacterium glutamicum putative glutaredoxin NrdH (nrdH), Nrdl
Corynebacterium 99,499 5-Aug-99 (nrdl), and ribonucleotide
reductase alpha-chain (nrdE) genes, complete cds. glutamicum
GB_PR3: HSH3D2 1789 AF053138 Homo sapiens histone deacetylase 3
gene, exons 11, 12, 13 and partial cds. Homo sapiens 33,512
28-MAR-1998 GB_PR4: AF059650 16015 AF059650 Homo sapiens histone
deacetylase 3 (HDAC3) gene, complete cds. Homo sapiens 38,814
03-MAR-1999 rxa01085 902 GB_EST4: H55032 951 H55032 HHU58a Sorghum
bicolor cv. TX430 Sorghum bicolor cDNA clone HHU58 Sorghum bicolor
41,111 27-Sep-99 5' similar to transketolase, chloroplast (TKLC1),
mRNA sequence. GB_HTG2: HSBA27F12 123489 AL109914 Homo sapiens
chromosome 6 clone RP11-27F12 map p22.3-24, Homo sapiens 35,156
30-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces.
GB_HTG2: HSBA27F12 123489 AL109914 Homo sapiens chromosome 6 clone
RP11-27F12 map p22.3-24, Homo sapiens 35,156 30-Nov-99 ***
SEQUENCING IN PROGRESS ***, in unordered pieces. rxa01088 1305
GB_HTG5: AC010202 170004 AC010202 Homo sapiens chromosome 12q
seeders clone RP11-210L7, Homo sapiens 37,313 6-Nov-99 ***
SEQUENCING IN PROGRESS ***, 40 unordered pieces. IN PROGRESS
GB_HTG5: AC010202 170004 AC010202 Homo sapiens chromosome 12q
seeders clone RP11-210L7, *** SEQUENCING Homo sapiens 37,422
6-Nov-99 ***, 40 unordered pieces. GB_PR1: HSIGFACI 7260 X57025
Human IGF-I mRNA for insulin-like growth factor I. Homo sapiens
38,043 17-Feb-92 rxa01091 664 GB_BA1: ECORELA 4034 J04039 E. coli
relA gene encoding ATP: GTP 3'-pyrophosphotransferase, complete
cds. Escherichia coli 54,711 16-Nov-93 GB_BA2: ECU29580 13234
U29580 Escherichia coli K-12 genome; approximately 62 minute
region. Escherichia coli 37,327 5-Apr-99 GB_BA2: AE000362 12595
AE000362 Escherichia coli K-12 MG1655 section 252 of 400 of the
complete genome. Escherichia coli 37,327 12-Nov-98 rxa01096 547
GB_PL1: PCX24CRY 357 Z34459 P. cryptogea X24 gene for cryptogein.
Phytophthora cryptogea 43,31 19-Sep-96 GB_EST24: AI244520 414
AI244520 qk14c08.x1 NCI_CGAP_Kid3 Homo sapiens cDNA clone IMAGE:
1868942 3', Homo sapiens 33,528 28-Jan-99 mRNA sequence. GB_RO:
MM26SPROT 1479 Y13071 Mus musculus mRNA for 26S proteasome
non-ATPase subunit. Mus musculus 37,941 10-Sep-98 rxa01102 1368
GB_HTG3: AC009219 127519 AC009219 Drosophila melanogaster
chromosome 3 clone BACR32N16 (D973) RPCI-98 32.N.16 Drosophila
melanogaster 35,08 20-Aug-99 map 86C-86C strain y; cn bw sp, ***
SEQUENCING IN PROGRESS***, 74 unordered pieces. GB_HTG3: AC009219
127519 AC009219 Drosophila melanogaster chromosome 3 clone
BACR32N16 (D973) RPCI-98 32.N.16 Drosophila melanogaster 35,08
20-Aug-99 map 86C-86C strain y; cn bw sp, *** SEQUENCING IN
PROGRESS ***, 74 unordered pieces. GB_PR4: AC006065 191134 AC006065
Homo sapiens 12q24.2 BAC RPCI11-407A16 (Roswell Park Cancer
Institute Homo sapiens 37,453 27-Feb-99 Human BAC Library) complete
sequence. rxa01103 348 GB_EST13: AA340958 338 AA340958 EST46332
Fetal kidney II Homo sapiens cDNA 5' end, mRNA sequence. Homo
sapiens 36,596 21-Apr-97 GB_RO: MUSBCL22 5806 L31532 Mus musculus
bcl-2 alpha gene, exon 2. Mus musculus 33,913 5-Apr-94 GB_BA2:
AE001165 13021 AE001165 Borrelia burgdorferi (section 51 of 70) of
the complete genome. Borrelia burgdorferi 31,412 15-DEC-1997
rxa01107 1323 GB_HTG1: HS1030M6 173804 AL035089 Homo sapiens
chromosome 20 clone RP5-1030M6, *** SEQUENCING IN Homo sapiens
34,935 23-Nov-99 PROGRESS ***, inunordered pieces. GB_HTG1:
HS1030M6 173804 AL035089 Homo sapiens chromosome 20 clone
RP5-1030M6, *** SEQUENCING IN Homo sapiens 34,935 23-Nov-99
PROGRESS ***, in unordered pieces. GB_HTG2: AC005057 99370 AC005057
Homo sapiens clone RG052H06, *** SEQUENCING IN PROGRESS ***, 11
Homo sapiens 35,897 12-Jun-98 unordered pieces. rxa01108 774
GB_PR2: HSJ193N13 122961 AL078600 Human DNA sequence from clone
RP1-193N13 on chromosome Homo sapiens 37,115 22-Nov-99 6q21-22.31,
complete sequence. GB_EST34: AV139054 287 AV139054 AV139054 Mus
musculus C57BL/6J 10-11 day embryo Mus musculus cDNA Mus musculus
35,54 1-Jul-99 clone 2810048D09, mRNA sequence. GB_PL1: GTU21246
926 U21246 Gracilariopsis tenuifrons Internal transcribed spacer
region of the Gracilariopsis tenuifrons 37,2 12-MAR-1995 ribosomal
repeat, ITS1, 5.8S rRNA gene and ITS2, complete sequence. rxa01109
765 GB_BA1: AB003332 1424 AB003332 Anabaena variabilis rbpF gene
for RNA binding protein, complete cds. Anabaena variabilis 35,958
21-MAY-1999 GB_BA1: BPETOXOP 9342 L10720 Bordetella pertussis toxin
liberation operon. Bordetella pertussis 40,107 9-Jul-93 GB_PAT:
I50844 951 I50844 Sequence 12 from patent U.S. Pat. No. 5643747.
Unknown. 39,973 07-OCT-1997 rxa01119 1053 GB_GSS3: B36708 438
B36708 HS-1041-B1-C05-MF.abi CIT Human Genomic Sperm Library C Homo
Homo sapiens 37,3 17-OCT-1997 sapiens genomic clone Plate = CT 823
Col = 9 Row = F, genomic survey sequence. GB_PL2: F11A17 102077
AC007932 Arabidopsis thaliana chromosome 1 BAC F11A17 sequence,
complete sequence. Arabidopsis thaliana 37,488 16-Aug-99 GB_EST22:
AI043264 283 AI043264 TENU0904 T. cruzi epimastigote normalized
cDNA Library Trypanosoma Trypanosoma cruzi 40,989 1-Jul-98 cruzi
cDNA clone 2i14 3',mRNA sequence. rxa01121 1209 GB_PAT: I78756 737
I78756 Sequence 12 from patent U.S. Pat. No. 5693781. Unknown.
40,975 3-Apr-98 GB_PAT: I92045 737 I92045 Sequence 12 from patent
U.S. Pat. No. 5726299. Unknown. 40,975 01-DEC-1988 GB_PL1: MTPACG
100314 X55026 P. anserina complete mitochondrial genome.
Mitochondrion Podospora 34,477 08-DEC-1997 anserina rxa01122 645
GB_HTG4: AC010148 228794 AC010148 Homo sapiens chromosome unknown
Homo sapiens 42,13 29-OCT-1999 clone NH0367B19, WORKING DRAFT
SEQUENCE, inunordered pieces. GB_HTG4: AC010148 228794 AC010148
Homo sapiens chromosome unknown clone Homo sapiens 42,13
29-OCT-1999 NH0367B19, WORKING DRAFT SEQUENCE, inunordered pieces.
GB_HTG4: AC010148 228794 AC010148 Homo sapiens chromosome unknown
clone Homo sapiens 37,559 29-OCT-1999 NH0367B19, WORKING DRAFT
SEQUENCE, inunordered pieces. rxa01123 570 GB_EST33: AV090612 274
AV090612 AV090612 Mus musculus tongue C57BL/6J adult Mus musculus
33,212 28-Jun-99 Mus musculus cDNA clone 2310051C21, mRNA sequence.
GB_EST33: AV090612 274 AV090612 AV090612 Mus musculus tongue
C57BL/6J adult Mus Mus musculus 34,529 28-Jun-99 musculus cDNA
clone 2310051C21, mRNA sequence. rxa01127 1143 GB_BA1: CGLEUB 2042
Y09578 C. glutamicum leuB gene. Corynebacterium 99,913 02-MAR-1999
glutamicum GB_BA1: MTV012 70287 AL021287 Mycobacterium tuberculosis
H37Rv complete genome; segment 132/162. Mycobacterium 39,295
23-Jun-99 tuberculosis GB_BA1: SC1C2 42210 AL031124 Streptomyces
coelicolor cosmid 1C2. Streptomyces coelicolor 62,456 15-Jan-99
rxa01128 1137 GB_BA1: CGLEUB 2042 Y09578 C. glutamicum leuB gene.
Corynebacterium 38,515 02-MAR-1999 glutamicum GB_GSS8: AQ066341 241
AQ066341 HS_2243_B1_A02_MF CIT Homo sapiens 39,004 4-Aug-98
Approved Human Genomic Sperm Library D Homo sapiens genomic clone
Plate = 2243 Col = 3 Row = B, genomic survey sequence. GB_EST24:
AI168493 459 AI168493 ou64g08.s1 NCI_CGAP_Br2 Homo sapiens cDNA
clone IMAGE: Homo sapiens 42,117 23-OCT-1998 1632638 3' similar to
gb: D90209 DNA-BINDING PROTEIN TAXREB67 (HUMAN);, mRNA sequence.
rxa01129 1989 GB_BA1: MTCI28 36300 Z97050 Mycobacterium
tuberculosis H37Rv complete genome; segment 10/162. Mycobacterium
38,159 23-Jun-98 tuberculosis GB_HTG1: LMFL6852 37286 AL034359
Leishmania major chromosome 4 clone L6852 strain Freidlin, ***
SEQUENCING Leishmania major 38,485 29-Apr-99 IN PROGRESS ***, in
unordered pieces. GB_HTG1: LMFL6852 37286 AL034359 Leishmania major
chromosome 4 clone L6852 strain Freidlin, *** SEQUENCING Leishmania
major 38,485 29-Apr-99 IN PROGRESS ***, in unordered pieces.
rxa01131 990 GB_BA1: CGLEUB 2042 Y09578 C. glutamicum leuB gene.
Corynebacterium 99,313 02-MAR-1999 glutamicum GB_PR4: AC007253
225699 AC007253 Homo sapiens BAC clone NH0454P05 from 2, complete
sequence. Homo sapiens 35,421 22-OCT-1999 GB_HTG3: AC011305 171067
AC011305 Homo sapiens clone NH0390E09, *** SEQUENCING Homo sapiens
35,955 05-OCT-1999 IN PROGRESS ***, 1 unordered pieces. rxa01134
871 GB_HTG4: AC009375 137069 AC009375 Drosophila melanogaster
chromosome 3L/75A1 clone Drosophila melanogaster 37,38 16-OCT-1999
RPCI98-44L18, *** SEQUENCING IN PROGRESS ***, 59 unordered pieces.
GB_HTG4: AC009375 137069 AC009375 Drosophila melanogaster
chromosome 3L/75A1 clone RPCI98-44L18, Drosophila melanogaster
37,38 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 59 unordered
pieces. GB_HTG4: AC009375 137069 AC009375 Drosophila melanogaster
chromosome 3L/75A1 clone RPCI98-44L18, Drosophila melanogaster
38,489 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 59 unordered
pieces. rxa01137 483 GB_IN2: AC005421 69992 AC005421 Drosophila
melanogaster, chromosome 2L, region Drosophila melanogaster 37,387
31-OCT-1998 22A1-22A1, P1 clone DS03601, complete sequence.
GB_GSS1: CNS00KX9 1101 AL078350 Drosophila melanogaster genome
survey sequence TET3 end Drosophila melanogaster 30,67 3-Jun-99 of
BAC: BACR23A23 of RPCI-98 library from Drosophila melanogaster
(fruit fly), genomic survey sequence. GB_IN2: AC005421 69992
AC005421 Drosophila melanogaster, chromosome 2L, region 22A1-22A1,
P1 Drosophila melanogaster 33,333 31-OCT-1998 clone DS03601,
complete sequence. rxa01140 1056 GB_PR4: AC007948 99904 AC007948
Genomic sequence of Homo sapiens clone R417F14A from chromosome 18,
Homo sapiens 36,249 6-Nov-99 complete sequence.
GB_HTG3: AC006278 140290 AC006278 Plasmodium falciparum chromosome
12 clone 3D7, *** SEQUENCING Plasmodium falciparum 36,592 23-Sep-99
IN PROGRESS ***, 18 unordered pieces. GB_HTG3: AC006278 140290
AC006278 Plasmodium falciparum chromosome 12 clone 3D7, ***
SEQUENCING Plasmodium falciparum 36,592 23-Sep-99 IN PROGRESS ***,
18 unordered pieces. rxa01148 723 GB_BA1: MTCY261 27322 Z97559
Mycobacterium tuberculosis H37Rv complete genome; segment 95/162.
Mycobacterium 50,139 17-Jun-98 tuberculosis GB_EST15: AA501229 548
AA501229 vh62g12.r1 Knowles Solter mouse 11 5day limb bud Mus
musculus Mus musculus 36,25 1-Jul-97 cDNA clone IMAGE: 891622 5'
similar to TR: G762951 G762951 PRPL-2 PROTEIN;, mRNA sequence.
GB_PR4: AF106062 1306 AF106062 Homo sapiens Wiskott-Aldrich
syndrome protein interacting Homo sapiens 43,205 31-Jul-99 protein
(WASPIP) mRNA, partial cds. rxa01153 543 GB_BA1: MTCY261 27322
Z97559 Mycobacterium tuberculosis H37Rv complete genome; segment
95/162. Mycobacterium 40 17-Jun-98 tuberculosis GB_BA1: MLCB2533
40245 AL035310 Mycobacterium leprae cosmid B2533. Mycobacterium
leprae 61,765 27-Aug-99 GB_BA1: U00017 42157 U00017 Mycobacterium
leprae cosmid B2126. Mycobacterium leprae 39,615 01-MAR-1994
rxa01154 677 GB_BA1: MTCY49 39430 Z73966 Mycobacterium tuberculosis
H37Rv complete genome; segment 93/162. Mycobacterium 37,615
24-Jun-99 tuberculosis GB_BA1: U00017 42157 U00017 Mycobacterium
leprae cosmid B2126. Mycobacterium leprae 36,957 01-MAR-1994
GB_BA2: AF086832 10612 AF086832 Streptomyces coelicolor putative
Streptomyces coelicolor 53,354 30-Jun-99 ferredoxin, ARC (arc), 20S
proteasome beta-subunit precursor (prcB), 20S proteasome
alpha-subunit (prcA), putative LacI family repressor, and putative
transporter genes, complete cds; and unknown genes. rxa01155 1570
GB_BA1: MTCY49 39430 Z73966 Mycobacterium tuberculosis H37Rv
complete genome; segment 93/162. Mycobacterium 37,025 24-Jun-99
tuberculosis GB_BA1: REZ82005 3301 Z82005 R. erythropolis DNA, 20S
proteasome structural genes region (3301 bp). Rhodococcus
erythropolis 54,128 8-Nov-97 GB_BA2: RSU26422 3554 U26422
Rhodococcus erythropolis ORF6(2), ORF7(2), proteasome beta-type
subunit Rhodococcus erythropolis 45,951 08-OCT-1997 2 (prcB(2)),
and proteasome alpha-type subunit 2 (prcA(2))genes, complete cds.
rxa01156 257 GB_BA2: RSU26422 3554 U26422 Rhodococcus erythropolis
ORF6(2), ORF7(2), proteasome Rhodococcus erythropolis 54,724
08-OCT-1997 beta-type subunit 2 (prcB(2)), and proteasome
alpha-type subunit 2 (prcA(2)) genes, complete cds. GB_HTG6:
AC009218 126649 AC009218 Drosophila melanogaster chromosome 2 clone
BACR33D17 (D945) Drosophila melanogaster 42,57 02-DEC-1999 RPCI-98
33.D.17 map 57B-57B strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 76 unordered pieces. GB_OV: QULNFLW 7933 D13223 Japanese quail
genomic DNA for neurofilament-L (NF-L). Coturnix coturnix 44,758
3-Feb-99 rxa01158 1065 GB_HTG3: AC011401 321277 AC011401 Homo
sapiens chromosome 5 Homo sapiens 35,048 06-OCT-1999 clone
CIT978SKB_35K5, *** SEQUENCING IN PROGRESS ***, 65 unordered
pieces. GB_HTG3: AC011401 321277 AC011401 Homo sapiens chromosome 5
clone CIT978SKB_35K5, Homo sapiens 35,048 06-OCT-1999 ***
SEQUENCING IN PROGRESS ***, 65 unordered pieces. GB_PR3: AC004386
172657 AC004386 Homo sapiens Chromosome X clone bWXD691, complete
sequence. Homo sapiens 37,223 10-Apr-98 rxa01159 438 GB_PAT: I92035
413 I92035 Sequence 2 from patent U.S. Pat. No. 5726299. Unknown.
78,169 01-DEC-1998 GB_PAT: I78746 413 I78746 Sequence 2 from patent
U.S. Pat. No. 5693781. Unknown. 78,169 3-Apr-98 GB_HTG3: AC009209
108370 AC009209 Drosophila melanogaster chromosome 2 Drosophila
melanogaster 43,59 20-Aug-99 clone BACR24G16 (D1051) RPCI-98
24.G.16 map 47D- 47D strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 93 unordered pieces. rxa01160 998 GB_PAT: I78746 413 I78746
Sequence 2 from patent U.S. Pat. No. 5693781. Unknown. 96,032
3-Apr-98 GB_PAT: I92035 413 I92035 Sequence 2 from patent U.S. Pat.
No. 5726299. Unknown. 96,032 01-DEC-1998 GB_BA2: AF014804 6449
AF014804 Neisseria meningitidis PglB (pglB), PglC Neisseria
meningitidis 37,977 3-Sep-99 (pglC), PglD (pglD), and AvtA (avtA)
genes, complete cds. rxa01165 696 GB_HTG2: AC007851 128979 AC007851
Drosophila melanogaster Drosophila melanogaster 37,9 2-Aug-99
chromosome 2 clone BACR06M19 (D615) RPCI-98 06.M.19 map 50C-50D
strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 86 unordered
pieces. GB_HTG2: AC007851 128979 AC007851 Drosophila melanogaster
chromosome Drosophila melanogaster 37,9 2-Aug-99 2 clone BACR06M19
(D615) RPCI-98 06.M.19 map 50C-50D strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 86 unordered pieces. GB_HTG2: AC007851
128979 AC007851 Drosophila melanogaster chromosome Drosophila
melanogaster 34,114 2-Aug-99 2 clone BACR06M19 (D615) RPCI-98
06.M.19 map 50C-50D strain y; cn bw sp, *** SEQUENCING IN
PROGRESS***, 86 unordered pieces. rxa01166 1428 GB_BA1: LEUG6PD
1957 M64446 L. mesenteroides glucose-6-phosphate dehydrogenase
gene, complete cds. Leuconostoc 41,259 26-Apr-93 mesenteroides
GB_HTG3: AF188026 101456 AF188026 Homo sapiens chromosome 8 Homo
sapiens 35,535 08-OCT-1999 clone BAC 2379L20 map 8q24, ***
SEQUENCING IN PROGRESS ***, in ordered pieces. GB_HTG3: AF188026
101456 AF188026 Homo sapiens chromosome 8 Homo sapiens 35,535
08-OCT-1999 clone BAC 2379L20 map 8q24, *** SEQUENCING IN PROGRESS
***, in ordered pieces. rxa01167 519 GB_PR2: HS1026E2 100418
AL022143 Human DNA sequence Homo sapiens 38,281 23-Nov-99 from
clone 1026E2 on chromosome 1q24.1-25.3 EST, CA repeat, STS, GSS,
complete sequence. GB_EST36: AI900015 496 AI900015 sb97f05.y1
Gm-c1012 Glycine max Glycine max 42,045 06-DEC-1999 cDNA clone
GENOME SYSTEMS CLONE ID: Gm-c1012-634 5' similar to WP: T11G6.8
CE06432 RNA RECOGNITION MOTIF.;, mRNA sequence. GB_PR2: HS1026E2
100418 AL022143 Human DNA sequence from clone Homo sapiens 40,99
23-Nov-99 1026E2 on chromosome 1q24.1-25.3 EST, CA repeat, STS,
GSS, complete sequence. rxa01169 1119 GB_HTG2: AC005978 92586
AC005978 Drosophila melanogaster chromosome 2 clone Drosophila
melanogaster 34,266 30-Jul-99 DS00678 (D449) map 59D3-59D4 strain
y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 6 unordered pieces.
GB_HTG2: AC005978 92586 AC005978 Drosophila melanogaster chromosome
2 clone DS00678 Drosophila melanogaster 34,266 30-Jul-99 (D449) map
59D3-59D4 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 6
unordered pieces. GB_HTG3: AC008304 91552 AC008304 Drosophila
melanogaster chromosome 2 clone BACR04G19 Drosophila melanogaster
31,278 20-Sep-99 (D646) RPCI-98 04.G.19 map 59D2-59D3 strain y; cn
bw sp, *** SEQUENCING IN PROGRESS ***, 90 unordered pieces.
rxa01170 606 GB_PR1: AB014524 6542 AB014524 Homo sapiens mRNA for
KIAA0624 protein, partial cds. Homo sapiens 43,478 6-Feb-99
GB_EST38: AW016078 496 AW016078 UI-H-BI0p-abf-h-01-0-UI.s1
NCI_CGAP_Sub2 Homo sapiens Homo sapiens 36,667 10-Sep-99 cDNA clone
IMAGE: 2711665 3', mRNA sequence. GB_EST24: AI193238 323 AI193238
qe56c06.x1 Soares_fetal_lung_NbHL19W Homo sapiens 37,427
29-OCT-1998 Homo sapiens cDNA clone IMAGE: 1742986 3', mRNA
sequence. rxa01171 816 GB_HTG2: AC007548 110249 AC007548 Drosophila
melanogaster chromosome 2 clone Drosophila melanogaster 35,634
2-Aug-99 BACR48M17 (D614) RPCI-98 48.M.17 map 41C-41D strain y; cn
bw sp, *** SEQUENCING IN PROGRESS ***, 66 unordered pieces. GB_PR3:
HS273F20 111253 AL034371 Human DNA sequence from clone 273F20 on
chromosome 6q16.1-16.3 Homo sapiens 34,582 23-Nov-99 Contains ESTs,
STSs and GSSs, complete sequence. GB_HTG2: AC007548 110249 AC007548
Drosophila melanogaster chromosome 2 clone BACR48M17 Drosophila
melanogaster 35,634 2-Aug-99 (D614) RPCI-98 48.M.17 map 41C-41D
strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 66 unordered
pieces. rxa01173 738 GB_GSS8: B93272 338 B93272 CIT-HSP-2171E14.TF
CIT-HSP Homo sapiens genomic Homo sapiens 42,012 25-Jun-98 clone
2171E14, genomic survey sequence. GB_EST35: AV156265 282 AV156265
AV156265 Mus musculus head C57BL/6J 12-day embryo Mus musculus
41,35 7-Jul-99 Mus musculus cDNA clone 3000001I03, mRNA sequence.
GB_RO: AF035777 2154 AF035777 Mus musculus somatostatin receptor
subtype 5 (sst5) gene, complete cds. Mus musculus 38,928
05-DEC-1997 rxa01174 873 GB_HTG1: CEY51A2_3 110000 Z99275
Caenorhabditis elegans chromosome V clone Y51A2, Caenorhabditis
elegans 38,045 3-Dec-98 *** SEQUENCING IN PROGRESS ***, in
unordered pieces. GB_IN1: CEY51A2D 139259 AL021497 Caenorhabditis
elegans cosmid Y51A2D, complete sequence. Caenorhabditis elegans
38,045 2-Sep-99 GB_HTG1: CEY51A2_3 110000 Z99275 Caenorhabditis
elegans chromosome V clone Y51A2, Caenorhabditis elegans 38,045
3-Dec-98 *** SEQUENCING IN PROGRESS ***, in unordered pieces.
rxa01176 627 GB_BA1: MTV021 23400 AL021957 Mycobacterium
tuberculosis H37Rv complete genome; segment 97/162. Mycobacterium
39,159 18-Jun-98 tuberculosis GB_BA1: MSGB1551CS 36548 L78813
Mycobacterium leprae cosmid B1551 DNA sequence. Mycobacterium
leprae 53,215 15-Jun-96 GB_BA1: MSGB1554CS 36548 L78814
Mycobacterium leprae cosmid B1554 DNA sequence. Mycobacterium
leprae 53,215 15-Jun-96 rxa01177 rxa01178 573 GB_PR4: AC006126
46100 AC006126 Homo sapiens chromosome 19, cosmid F18718, complete
sequence. Homo sapiens 36,832 17-DEC-1998 GB_PR4: AC006126 46100
AC006126 Homo sapiens chromosome 19, cosmid F18718, complete
sequence. Homo sapiens 40,463 17-DEC-1998 GB_EST23: AI128078 443
AI128078 qc47d10.x1 Soares_pregnant_uterus_NbHPU Homo Homo sapiens
38,318 27-OCT-1998 sapiens cDNA clone IMAGE: 1712755 3' similar to
SW: IF16_HUMAN Q16666 GAMMA-INTERFERON-INDUCIBLE PROTEIN IFI-16;,
mRNA sequence. rxa01184 1596 GB_HTG2: HSG248A21 96783 AL118512 Homo
sapiens chromosome 1 clone GS1-248A21, *** SEQUENCING Homo sapiens
36,994 30-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG2:
HSG248A21 96783 AL118512 Homo sapiens chromosome 1 clone
GS1-248A21, *** SEQUENCING Homo sapiens 38,994 30-Nov-99 IN
PROGRESS ***, in unordered pieces. GB_PR3: AC004237 38715 AC004237
Homo sapiens chromosome 5, P1 clone 565a12 (LBNL N23). complete
sequence. Homo sapiens 36,514 27-Feb-98 rxa01186 1221 GB_BA1:
MTCY274 39991 Z74024 Mycobacterium tuberculosis N37Rv complete
genome; segment 126/162. Mycobacterium 34,758 19-Jun-98
tuberculosis GB_BA1: SC6A9 39461 AL031035 Streptomyces coelicolor
cosmid 6A9. Streptomyces coelicolor 38,5 24-Jul-98 GB_BA2: AE000689
14698 AE000689 Aquifex aeolicus section 21 of 109 of the complete
genome. Aquifex aeolicus 45,379 25-MAR-1998 rxa01187 573 GB_EST5:
H60943 361 H60943 yr14g08.r1 Soares fetal liver spleen 1NFLS Homo
sapiens cDNA clone IMAGE: Homo sapiens 39,205 06-OCT-1995 205310
5', mRNA sequence. GB_GSS1: AG018858 570 AG018858 Homo sapiens
genomic DNA, 21q region, clone: B125C11 SpN045(-21), genomic Homo
sapiens 41,423 10-OCT-1999 survey sequence. GB_GSS13: AQ454839 505
AQ454839 HS_5218_A1_E03_T7A RPCI-11 Human Male Homo sapiens 34,599
21-Apr-99 BAC Library Homo sapiens genomic clone Plate = 794 Col =
5 Row = I, genomic survey sequence. rxa01195 570 GB_PR3: AF022813
1358 AF022813 Homo sapiens tetraspan (NAG-2) mRNA, complete cds.
Homo sapiens 40,614 18-Nov-97 GB_EST34: AI798721 765 AI798721
we91g10.x1 Soares_NFL_T_GBC_S1 Homo sapiens 35,256 6-Jul-99 Homo
sapiens cDNA clone IMAGE: 2348514 3' similar to SW: NAG2_HUMAN
O14817 NOVEL ANTIGEN 2;, mRNA sequence. GB_EST34: AI808898 696
AI808898 wf66d02.x1 Soares_NFL_T_GBC_S1 Homo sapiens 35,354
7-Jul-99 Homo sapiens cDNA clone IMAGE: 2360547 3' similar to SW:
NAG2_HUMAN O14817 NOVEL ANTIGEN 2;, mRNA sequence. rxa01196 813
GB_BA1: MSGY151 37036 AD000018 Mycobacterium tuberculosis sequence
from clone y151. Mycobacterium 36,634 10-DEC-1996 tuberculosis
GB_BA1: MTCY130 32514 Z73902 Mycobacterium tuberculosis H37Rv
complete genome; segment 59/162. Mycobacterium 59,596 17-Jun-98
tuberculosis GB_BA1: MSGY151 37036 AD000018 Mycobacterium
tuberculosis sequence from clone y151. Mycobacterium 39,567
10-DEC-1996 tuberculosis rxa01197 576 GB_EST18: AA676822 524
AA676822 zj65c11.s1 Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens
40,741 19-DEC-1997 Homo sapiens cDNA clone IMAGE: 455156 3', mRNA
sequence. GB_EST18: AA676822 524 AA676822 zj65c11.s1
Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens cDNA Homo sapiens
40,331 19-DEC-1997 clone IMAGE: 455156 3', mRNA sequence. rxa01198
426 GB_HTG4: AC010195 164935 AC010195 Homo sapiens chromosome 10
clone RPCI11-587C2, *** SEQUENCING Homo sapiens 36,058 21-OCT-1999
IN PROGRESS ***, 61 unordered pieces. GB_HTG4: AC010195 164935
AC010195 Homo sapiens chromosome 10 clone RPCI11-587C2, ***
SEQUENCING Homo sapiens 36,058 21-OCT-1999 IN PROGRESS ***, 61
unordered pieces. GB_HTG1: CEY44A6 326074 Z98863 Caenorhabditls
elegans chromosome V clone Y44A6, *** Caenorhabditis elegans 39,151
03-DEC-1998 SEQUENCING IN PROGRESS ***, in unordered pieces.
rxa01206 400 GB_HTG1: CER08A5 51920 Z82281 Caenorhabditis
elegans
chromosome V clone R08A5, Caenorhabditis elegans 43,557 14-OCT-1998
*** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1:
CER08A5 51920 Z82281 Caenorhabditis elegans chromosome V clone
R08A5, Caenorhabditis elegans 43,557 14-OCT-1998 *** SEQUENCING IN
PROGRESS ***, in unordered pieces. GB_HTG1: CER08A5 51920 Z82281
Caenorhabditis elegans chromosome V clone R08A5, Caenorhabditis
elegans 34,987 14-OCT-1998 *** SEQUENCING IN PROGRESS ***, in
unordered pieces. rxa01207 771 GB_PL2: SPBC8D2 43757 AL022072 S.
pombe chromosome II cosmid c8D2. Schizosaccharomyces 36,566
24-Nov-99 pombe GB_PL1: AB004538 38911 AB004538 Schizosaccharomyces
pombe 39 kb genomic DNA, clone c568. Schizosaccharomyces 36,148
15-Jul-97 pombe GB_HTG6: AC009220 110000 AC009220 Homo sapiens
chromosome 7, *** SEQUENCING IN PROGRESS ***, Homo sapiens 33,94
15-Sep-99 191 unordered pieces. rxa01210 954 GB_GSS4: AQ694235 530
AQ694235 HS_5496_A1_D03_T7A RPCI-11 Human Male BAC Library Homo
sapiens 37,259 6-Jul-99 Homo sapiens genomic clone Plate = 1072 Col
= 5 Row = G, genomic survey sequence. GB_GSS11: AQ322059 519
AQ322059 RPCI11-100G10.TV RPCI-11 Homo sapiens genomic clone Homo
sapiens 37,229 06-MAY-1999 RPCI-11-100G10, genomic survey sequence.
GB_BA1: SCH24 41625 AL049826 Streptomyces coelicolor cosmid H24.
Streptomyces coelicolor 38,126 11-MAY-1999 rxa01213 1350 GB_PR3:
HS356B7 20733 AL031714 Human DNA sequence from clone 356B7 on
chromosome 16. Homo sapiens 36,684 23-Nov-99 Contains the UBE21
gene for ubiquitin-conjugating enzyme E21 (homologous to yeast
UBC9), and an RPS20 (40S Ribosomal protein S20) pseudogene.
Contains ESTs, STSs. GSSs and a putative CpG island, complete
sequence. GB_PR3: HS356B7 20733 AL031714 Human DNA sequence from
clone 356B7 on chromosome 16. Homo sapiens 39,621 23-Nov-99
Contains the UBE21 gene for ubiquitin-conjugating enzyme E21
(homologous to yeast UBC9), and an RPS20 (40S Ribosomal protein
S20) pseudogene. Contains ESTs, STSs. GSSs and a putative CpG
island, complete sequence. GB_PR1: HSEF1AL1 1815 X16870 Human DNA
for elongation factor 1-alpha (clone lambda-1. Homo sapiens 37,462
12-Jun-90 rxa01218 552 GB_PR3: HS257I9 90695 AL031773 Human DNA
sequence from clone 257I9 on chromosome 6q25.1-26 Homo sapiens
35,897 23-Nov-99 Contains gene similar to Cytochrome B, CA repeat,
GSS, complete sequence. GB_PR3: HS287L14 112831 Z95325 Human DNA
sequence from clone 287L14 on chromosome Xq21.1-21.33 Homo sapiens
37,778 23-Nov-99 Contains STSs and GSSs, complete sequence.
GB_EST8: AA035251 493 AA035251 zk23d09.s1
Soares_pregnant_uterus_NbHPU Homo sapiens cDNA Homo sapiens 40,191
10-MAY-1997 clone IMAGE: 471377 3', mRNA sequence. rxa01229 1401
GB_PR4: HUAC002394 107910 AC002394 Human Chromosome 16 BAC clone
CIT987SK-A-211C6, complete sequence. Homo sapiens 33,633 23-Nov-99
GB_OV: AF138905 1678 AF138905 Gallus gallus NK class homeodomain
transcription Gallus gallus 30,556 4-Sep-99 factor NKX3.2 mRNA,
complete cds. GB_PAT: AR031772 30001 AR031772 Sequence 1 from
patent U.S. Pat. No. 5866410. Unknown. 34,304 29-Sep-99 rxa01231
366 GB_EST25: AI295169 507 AI295169 LP08720.3prime LP Drosophila
melanogaster larval-early pupal Drosophila melanogaster 38,279
01-DEC-1998 pOT2c Drosophila melanogaster cDNA clone LP08720
3prime, mRNA sequence. GB_EST25: AI297653 512 AI297653
LP12002.3prime LP Drosophila melanogaster larval-early pupal
Drosophila melanogaster 36,893 01-DEC-1998 pOT2 Drosophila
melanogaster cDNA clone LP12002 3prime, mRNA sequence. GB_EST21:
AA951454 677 AA951454 LD31920.5prime LD Drosophila melanogaster
embryo Drosophila melanogaster 44,167 24-Nov-98 pOT2 Drosophila
melanogaster cDNA clone LD31920 5prime, mRNA sequence. rxa01234 507
GB_GSS12: AQ365352 431 AQ365352 nbxb0063L13f CUGI Rice BAC
LibraryOryza sativa genomic Oryza sativa 34,677 3-Feb-99 clone
nbxb0063L13f, genomic survey sequence. GB_PR4: AC007544 119034
AC007544 Homo sapiens Human 12p11-37.2-54.4 BAC RPCI11-12D15
(Roswell Park Homo sapiens 34,35 29-OCT-1999 Cancer Institute Human
BAC Library) complete sequence. GB_PR4: AC007544 119034 AC007544
Homo sapiens Human 12p11-37.2-54.4 BAC RPCI11-12D15 (Roswell Park
Homo sapiens 37,988 29-OCT-1999 Cancer Institute Human BAC Library)
complete sequence. rxa01237 564 GB_GSS1: AG009269 706 AG009269 Homo
sapiens genomic DNA, 21q region, clone: 31C6X11, genomic survey
sequence. Homo sapiens 36,328 14-Apr-99 GB_GSS1: AG009269 706
AG009269 Homo sapiens genomic DNA, 21q region, clone: 31C6X11,
genomic survey sequence. Homo sapiens 37,391 14-Apr-99 rxa01246 630
GB_HTG2: AC007646 180133 AC007646 Drosophila melanogaster
chromosome 3 clone BACR03J04 Drosophila melanogaster 38,188
2-Aug-99 (D687) RPCI-98 03.J.4 map 87F-87F strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 10 unordered pieces. GB_HTG2: AC007646
180133 AC007646 Drosophila melanogaster chromosome 3 clone
BACR03J04 (D687) RPCI-98 Drosophila melanogaster 38,188 2-Aug-99
03.J.4 map 87F-87F strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 10 unordered pieces. GB_HTG4: AC009492 212394 AC009492 Homo
sapiens clone NH0423F09, *** SEQUENCING Homo sapiens 38,762
29-OCT-1999 IN PROGRESS ***, 2 unordered pieces. rxa01249 471
GB_EST7: W84105 361 W84105 T2969 MVAT4 bloodstream form of serodeme
WRATat1.1 Trypanosoma brucei 38,261 12-Aug-96 Trypanosoma brucei
rhodesiense cDNA 5', mRNA sequence. rhodesiense GB_EST7: W84105 361
W84105 T2969 MVAT4 bloodstream form of serodeme WRATat1.1
Trypanosoma brucei Trypanosoma brucei 33,894 12-Aug-98 rhodesiense
cDNA 5', mRNA sequence. rhodesiense rxa01251 432 GB_RO: AC005240
41830 AC005240 Mus musculus clone UWGC: magap from 14D1-D2 (T-cell
Receptor Mus musculus 41,463 8-Jul-98 Alpha Locus), complete
sequence. GB_RO: AC004101 39491 AC004101 Mouse Cosmid ma53a016 from
14D1-D2, complete sequence. Mus musculus 41,463 2-Feb-98 GB_HTG3:
AC009837 162287 AC009837 Homo sapiens chromosome 17 clone 550_K_23
map 17, *** SEQUENCING Homo sapiens 36,131 2-Sep-99 IN PROGRESS
***, 13 unordered pieces. rxa01263 1035 GB_PR4: AC005919 156300
AC005919 Homo sapiens chromosome 17, clone hRPK.142_H_19, complete
sequence. Homo sapiens 39,822 18-Nov-98 GB_PR4: AC005919 156300
AC005919 Homo sapiens chromosome 17, clone hRPK.142_H_19, complete
sequence. Homo sapiens 38,319 18-Nov-98 GB_HTG1: CEY71A12_3 110000
AL021390 Caenorhabditis elegans chromosome I clone Y71A12, ***
Caenorhabditis elegans 36,884 15-Sep-99 SEQUENCING IN PROGRESS ***,
in unordered pieces. rxa01266 1158 GB_HTG4: AC010775 165565
AC010775 Homo sapiens clone 2_G_17, *** SEQUENCING IN PROGRESS ***,
Homo sapiens 38,67 20-OCT-1999 14 unordered pieces. GB_HTG4:
AC010775 165565 AC010775 Homo sapiens clone 2_G_17, *** SEQUENCING
IN PROGRESS ***, Homo sapiens 38,67 20-OCT-1999 14 unordered
pieces. GB_HTG4: AC010775 165565 AC010775 Homo sapiens clone
2_G_17, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,131
20-OCT-1999 14 unordered pieces. rxa01267 1437 GB_PR3: AF070717
100793 AF070717 Homo sapiens BAC clone 393I22 from 8q21, Complete
sequence. Homo sapiens 38,826 2-Jul-98 GB_BA2: MPU34931 2571 U34931
Mycoplasma pulmonis FtsZ (ftsZ) gene, complete cds, methionyl-tRNA
synthetase Mycoplasma pulmonis 37,092 30-MAY-1996 (metG) gene,
partial cds. GB_EST25: AI322057 638 AI322057 SWOv3MCAM09A04SK
Onchocerca volvulus molting L3 larva cDNA Onchocerca volvulus
40,566 22-DEC-1998 (SL96MLW-OvmL3) Onchocerca volvulus cDNA clone
SWOv3MCAM09A04 5', mRNA sequence. rxa01268 963 GB_HTG3: AC010878
288945 AC010878 Homo sapiens clone NH0230E20, *** SEQUENCING IN
PROGRESS *** Homo sapiens 36,496 25-Sep-99 , 65 unordered pieces.
GB_HTG3: AC010878 288945 AC010878 Homo sapiens clone NH0230E20, ***
SEQUENCING IN PROGRESS ***, 65 Homo sapiens 36,496 25-Sep-99
unordered pieces. GB_HTG3: AC010878 288945 AC010878 Homo sapiens
clone NH0230E20, *** SEQUENCING IN PROGRESS ***, 65 Homo sapiens
36,354 25-Sep-99 unordered pieces. rxa01271 1935 GB_BA2: U67549
14561 U67549 Methanococcus jannaschii section 91 of 150 of the
complete genome. Methanococcus jannaschii 37,841 28-Jan-98 GB_PR2:
HSJ836N17 111694 AL049539 Human DNA sequence from clone RP5-836N17
on chromosome Homo sapiens 34,872 22-Nov-99 20q11.1-11.21, complete
sequence. GB_OV: AF089743 30676 AF089743 Morone saxatilis
homeodomain protein Hox-A10 (Hoxa10), homeodomain protein Morone
saxatilis 36,738 2-Aug-99 Hox-A9 (Hoxa9), homeodomain protein
Hox-A7 (Hoxa7), homeodomain protein Hox-A5 (Hoxa5), and homeodomain
protein Hox-A4 (Hoxa4) genes, complete cds. rxa01273 1557 GB_PR3:
AC004070 110192 AC004070 Human Chromosome X, complete sequence.
Homo sapiens 37,679 29-Jan-98 GB_PR2: AC002410 96217 AC002410 Human
BAC clone RG264L19 from 7p15-p21, complete sequence. Homo sapiens
38,587 11-Aug-97 GB_PR2: AC002410 96217 AC002410 Human BAC clone
RG264L19 from 7p15-p21, complete sequence. Homo sapiens 37,035
11-Aug-97 rxa01275 1041 GB_EST8: C03322 357 C03322 C03322 Human
heart cDNA (YNakamura) Homo sapiens cDNA clone Homo sapiens 35,393
30-Jul-96 3NHC1263, mRNA sequence. GB_EST4: R92079 410 R92079
yp96g02.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone
IMAGE: Homo sapiens 37,01 25-Aug-95 195314 5', mRNA sequence.
GB_EST4: H57724 461 H57724 yr21a12.r1 Soares fetal liver spleen
1NFLS Homo sapiens cDNA clone IMAGE: Homo sapiens 37,281
05-OCT-1995 205918 5', mRNA sequence. rxa01276 567 GB_OM: OCMYLC1
962 X54041 Rabbit mRNA for myosin light chain 1. Oryctolagus
cuniculus 40,503 26-Nov-90 GB_PR3: AC005383 123110 AC005383 Homo
sapiens chromosome 10 clone CIT987SK-1144G6 map 10q25.1, Homo
sapiens 38,93 31-OCT-1998 complete sequence. GB_RO: RATPTPECA 2155
D78610 Rat mRNA for protein tyrosine phosphatase epsilon C, partial
cds. Rattus norvegicus 37,77 5-Feb-99 rxa01281 885 GB_HTG4:
AC009366 199607 AC009366 Drosophila melanogaster chromosome 3L/79D4
clone RPCI98-48E10, Drosophila melanogaster 34,025 16-OCT-1999 ***
SEQUENCING IN PROGRESS ***, 31 unordered pieces. GB_HTG4: AC009366
199607 AC009366 Drosophila melanogaster chromosome 3L/79D4 clone
RPCI98-48E10, Drosophila melanogaster 34,025 16-OCT-1999 ***
SEQUENCING IN PROGRESS ***, 31 unordered pieces. GB_HTG4: AC009366
199607 AC009366 Drosophila melanogaster chromosome 3L/79D4 clone
RPCI98-48E10, Drosophila melanogaster 34,386 16-OCT-1999 ***
SEQUENCING IN PROGRESS ***, 31 unordered pieces. rxa01282 903
GB_GSS11: AQ263970 363 AQ263970 CITBI-E1-2503H24.TF CITBI-E1 Homo
sapiens genomic clone 2503H24, Homo sapiens 40,361 27-OCT-1998
genomic survey sequence. GB_GSS1: FR0025959 603 AL018794 F.
rubripes GSS sequence, clone 165E10aE1, genomic survey sequence.
Fugu rubripes 34,824 10-DEC-1997 GB_GSS9: AQ102435 334 AQ102435
HS_3038_B2_D09_MF CIT Approved Human Genomic Sperm Library D Homo
sapiens 37,624 27-Aug-98 Homo sapiens genomic clone Plate = 3038
Col = 18 Row = H, genomic survey sequence. rxa01294 789 GB_PL2:
AC007258 144422 AC007258 Arabidopsis thaliana chromosome I BAC
F23H11 genomic sequence, Arabidopsis thaliana 39,453 16-Jun-99
complete sequence. GB_EST17: T04634 491 T04634 681 Lambda-PRL1
Arabidopsis thaliana cDNA clone SBD1T7P, mRNA sequence. Arabidopsis
thaliana 38,693 6-Nov-97 GB_PL2: AC007258 144422 AC007258
Arabidopsis thaliana chromosome I BAC F23H11 genomic sequence,
Arabidopsis thaliana 36,17 16-Jun-99 complete sequence. rxa01295
1098 GB_HTG3: AC009803 235360 AC009803 Homo sapiens clone
RPCI11-1028N23, *** SEQUENCING Homo sapiens 38,662 24-Sep-99 IN
PROGRESS ***, 47 unordered pieces. GB_HTG3: AC009803 235360
AC009803 Homo sapiens clone RPCI11-1028N23, *** SEQUENCING IN Homo
sapiens 38,662 24-Sep-99 PROGRESS ***, 47 unordered pieces. GB_IN2:
AC004333 63178 AC004333 Drosophila melanogaster DNA sequence (P1
DS05969 (D229)), complete sequence. Drosophila melanogaster 39,252
20-Jun-98 rxa01296 1206 GB_PR4: AC004961 68130 AC004961 Homo
sapiens clone DJ1098J04, complete sequence. Homo sapiens 39,409
5-Jun-99 GB_GSS14: AQ525299 447 AQ525299 HS_5227_B2_H03_SP6E
RPCI-11 Human Male BAC Library Homo sapiens 37,33 11-MAY-1999 Homo
sapiens genomic clone Plate = 803 Col = 6 Row = P, genomic survey
sequence. GB_BA2: BFU78108 1900 U78108 Bacteroides fragilis NAD(H)
glutamate dehydrogenase (gdhB) gene, complete cds. Bacteroides
fragilis 40,509 15-Jul-98 rxa01301 648 GB_PR4: AC007051 167810
AC007051 Homo sapiens chromosome 3, clone hRPK.44_A_1, complete
sequence. Homo sapiens 38,498 11-Jun-99 GB_PR4: AC007919 184989
AC007919 Homo sapiens 3q26.2-27 BAC RPCI11-408H1 (Roswell Park
Cancer Institute Homo sapiens 35,139 09-OCT-1999 Human BAC Library)
complete sequence. GB_EST11: AA252547 454 AA252547 zp87g09.r1
Stratagene HeLa cell s3 937216 Homo sapiens cDNA Homo sapiens
38,538 12-MAR-1997 clone IMAGE: 627232 5' similar to gb: D13748
EUKARYOTIC INITIATION FACTOR 4A-I (HUMAN);, mRNA sequence. rxa01304
609 GB_HTG2: AC006779 119562 AC006779 Caenorhabditis elegans clone
Y47D7, *** SEQUENCING IN PROGRESS ***, 32 Caenorhabditis elegans
32,888 25-Feb-99 unordered pieces. GB_HTG2: AC006779 119562
AC006779 Caenorhabditis elegans clone Y47D7, *** SEQUENCING IN
PROGRESS ***, Caenorhabditis elegans 32,888 25-Feb-99 32 unordered
pieces.
GB_VI: BHT1UL 37000 Z78205 Bovine herpesvirus type 1 UL22-35 genes.
Bovine herpesvirus 1 38,047 14-Aug-96 rxa01306 1131 GB_GSS8:
AQ047475 420 AQ047475 cLM-1c5-t cLM Giardia intestinalis genomic,
genomic survey sequence. Giardia intestinalis 38,902 14-Jul-98
GB_PL1: CR1433P 1464 X79445 C. reinhardtii mRNA for 14-3-3 protein.
Chlamydomonas reinhardtii 39,64 06-OCT-1995 GB_PR3: HSJ878I13
122400 AL049591 Human DNA sequence from clone 878I13 on chromosome
Xq23-25 Contains Homo sapiens 35,624 23-Nov-99 a pseudogene similar
to alpha tubulin, ESTs, STSs, GSSs, complete sequence. rxa01310 450
GB_HTG3: AC010530 274508 AC010530 Homo sapiens chromosome 16 clone
RPCI-11_167P11, *** SEQUENCING Homo sapiens 38,462 15-Sep-99 IN
PROGRESS ***, 19 unordered pieces. GB_HTG3: AC010530 274508
AC010530 Homo sapiens chromosome 16 clone RPCI-11_167P11, ***
SEQUENCING IN Homo sapiens 38,462 15-Sep-99 PROGRESS ***, 19
unordered pieces. GB_HTG3: AC010530 274508 AC010530 Homo sapiens
chromosome 16 clone RPCI-11_167P11, *** SEQUENCING IN Homo sapiens
32,063 15-Sep-99 PROGRESS ***, 19 unordered pieces. rxa01313
rxa01315 774 GB_BA2: AF031037 1472 AF031037 Neisseria meningitidis
chloramphenicol acetyltransferase gene, complete cds. Neisseria
meningitidis 35,638 21-Apr-98 GB_GSS11: AQ326599 662 AQ326599
nbxb0037P01r CUGI Rice BAC Library Oryza sativa genomic clone
nbxb0037P01r, Oryza sativa 34,817 8-Jan-99 genomic survey sequence.
GB_HTG1: PFMAL13PA 80518 AL109815 Plasmodium falciparum chromosome
13 strain 3D7, *** SEQUENCING IN Plasmodium falciparum 34,935
19-Aug-99 PROGRESS ***, in unordered pieces. rxa01316 426 GB_HTG3:
AC010133 154773 AC010133 Homo sapiens clone NH0118E09, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 33,414 13-Sep-99 5
unordered pieces. GB_HTG3: AC010133 154773 AC010133 Homo sapiens
clone NH0118E09, *** SEQUENCING IN PROGRESS ***, Homo sapiens
33,414 13-Sep-99 5 unordered pieces. GB_HTG3: AC010133 154773
AC010133 Homo sapiens clone NH0118E09, *** SEQUENCING IN PROGRESS
***, Homo sapiens 38,186 13-Sep-99 5 unordered pieces. rxa01317 543
GB_BA2: U67560 12215 U67560 Methanococcus jannaschii section 102 of
150 of the complete genome. Methanococcus jannaschii 38,476
28-Jan-98 GB_BA2: U67560 12215 U67560 Methanococcus jannaschii
section 102 of 150 of the complete genome. Methanococcus jannaschii
35,867 28-Jan-98 rxa01318 1425 GB_BA1: MTV038 16094 AL021933
Mycobacterium tuberculosis H37Rv complete genome; segment 24/162.
Mycobacterium 51,266 17-Jun-98 tuberculosis GB_IN1: CELC41A3 37149
U41541 Caenorhabditis elegans cosmid C41A3. Caenorhabditis elegans
36,887 08-DEC-1995 GB_HTG3: AC011298 205637 AC011298 Homo sapiens
clone NH0118M12, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,76
05-OCT-1999 19 unordered pieces. rxa01326 489 GB_BA1: PAL249201
3390 AJ249201 Prevotella albensis ftsQ (partial), ftsA and ftsZ
genes and ORF-fts (partial). Prevotella albensis 37,708 27-Aug-99
GB_BA1: PAL249201 3390 AJ249201 Prevotella albensis ftsQ (partial),
ftsA and ftsZ genes and ORF-fts (partial). Prevotella albensis
37,474 27-Aug-99 rxa01330 rxa01331 2520 GB_HTG1: HSAJ02553 142807
AJ002553 Homo sapiens chromosome 11 clone 1118i22 map q13, ***
SEQUENCING IN Homo sapiens 26,237 14-Nov-97 PROGRESS ***, in
unordered pieces. GB_HTG1: HSAJ02553 142807 AJ002553 Homo sapiens
chromosome 11 clone 1118i22 map q13, *** SEQUENCING IN Homo sapiens
26,237 14-Nov-97 PROGRESS ***, in unordered pieces. GB_PR3:
AC005304 164017 AC005304 Homo sapiens chromosome 17, clone
hRPK.131_K_5, complete sequence. Homo sapiens 35,318 25-Jul-98
rxa01333 1128 GB_BA1: CGU43536 3464 U43536 Corynebacterium
glutamicum heat shock, ATP-binding protein (clpB) gene,
Corynebacterium 38,075 13-MAR-1997 complete cds. glutamicum GB_OM:
BTPRLP 924 X15975 Bovine mRNA for prolactin (PRL) related protein.
Boa taurus 40,901 22-DEC-1994 GB_OM: BTPRLP 924 X15975 Bovine mRNA
for prolactin (PRL) related protein. Boa taurus 39,58 22-DEC-1994
rxa01336 726 GB_BA1: AP000064 247695 AP000064 Aeropyrum pernix
genomic DNA, section 7/7. Aeropyrum pernix 37,881 22-Jun-99 GB_BA1:
AP000064 247695 AP000064 Aeropyrum pernix genomic DNA, section 7/7.
Aeropyrum pernix 36,161 22-Jun-99 GB_EST1: T05458 363 T05458
EST03347 Fetal brain, Stratagene (cat#936206) Homo sapiens cDNA
Homo sapiens 43,798 30-Jun-93 clone HFBCY86, mRNA sequence.
rxa01337 1536 GB_PR2: AP000215 100000 AP000215 Homo sapiens genomic
DNA, chromosome 21q22.3-ter, Ter region, Homo sapiens 36,438
20-Nov-99 clone f27E1-T1136, segment 1/4, complete sequence.
GB_PR2: AP000215 100000 AP000215 Homo sapiens genomic DNA,
chromosome 21q22.3-ter, Ter region, clone Homo sapiens 35,827
20-Nov-99 f27E1-T1136, segment 1/4, complete sequence. GB_PR2:
AP000337 53553 AP000337 Homo sapiens genomic DNA, chromosome
21q22.3-ter. Tar region, clone: T1957, Homo sapiens 36,043
20-Nov-99 complete sequence. rxa01342 626 GB_EST35: AI814229 544
AI814229 wj70e01.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone Homo
sapiens 36,803 24-Aug-99 IMAGE: 2408184 3', mRNA sequence.
GB_EST35: AI814229 544 AI814229 wj70e01.x1 NCI_CGAP_Lu19 Homo
sapiens cDNA clone IMAGE: Homo sapiens 36,688 24-Aug-99 2408184 3',
mRNA sequence. rxa01348 615 GB_HTG3: AC011246 210407 AC011246 Homo
sapiens clone NH0498O20, *** SEQUENCING IN PROGRESS ***, Homo
sapiens 39,101 04-OCT-1999 29 unordered pieces. GB_HTG3: AC011246
210407 AC011246 Homo sapiens clone NH0498O20, *** SEQUENCING IN
PROGRESS ***, Homo sapiens 39,101 04-OCT-1999 29 unordered pieces.
GB_PL1: ZMB32120 3093 X54212 Z. mays mRNA for b-32 protein,
putative regulatory factor of zein expression Zea mays 35,902
18-Jan-93 (clone b-32.120). rxa01349 900 GB_IN1: CELK10G6 33588
AF016669 Caenorhabditis elegans cosmid K10G6. Caenorhabditis
elegans 40,251 8-Aug-97 GB_IN1: CELK10G6 33588 AF016669
Caenorhabditis elegans cosmid K10G6. Caenorhabditis elegans 36,842
8-Aug-97 rxa01357 426 GB_BA1: MTCY274 39991 Z74024 Mycobacterium
tuberculosis H37Rv complete genome; segment 126/162. Mycobacterium
36,058 19-Jun-98 tuberculosis GB_BA1: MLCB250 40603 Z97369
Mycobacterium leprae cosmid B250. Mycobacterium leprae 59,294
27-Aug-99 GB_BA2: SKZ86111 7860 Z86111 Streptomyces lividans rpsP,
trmD, rplS, sipW, sipX, sipY, sipZ, mutT genes and Streptomyces
lividans 57,882 27-OCT-1999 4 open reading frames. rxa01359 1305
GB_BA1: D87820 7217 D87820 Vibrio cholerae non-O1 gene for
N-acetylglucosamine 6-phosphate Vibrio cholerae non-O1 38,152
17-OCT-1997 deacetylase, NagC, NagE, complete cds. GB_PR3: AC004540
131757 AC004540 Homo sapiens PAC clone DJ1066K24 from 7p15,
complete sequence. Homo sapiens 35,714 9-Apr-98 GB_PR2: HSU44119
450 U44119 Human der(9) chromosome breakpoint region: alpha 1(V)
collagen chain (COL5A1) Homo sapiens 38,085 14-Jan-97 gene, partial
intron 24, and imperfect LINE-1 element of Xp21.2. rxa01362 3677
GB_EST30: AI665031 602 AI665031 605005H05.x1 605 - Endosperm cDNA
library from Schmidt lab Zea mays Zea mays 42,308 11-MAY-1999 cDNA,
mRNA sequence. GB_EST34: AI795319 661 AI795319 605005H05.y2 605 -
Endosperm cDNA library from Schmidt lab Zea mays cDNA, Zea mays
38,729 2-Jul-99 mRNA sequence. GB_HTG3: AC008387 151804 AC008387
Homo sapiens chromosome 5 clone CIT-HSPC_229P9, *** SEQUENCING IN
Homo sapiens 38,023 3-Aug-99 PROGRESS ***, 74 unordered pieces.
rxa01366 513 GB_IN1: AF007166 1392 AF007166 Anopheles gambiae
serine protease 14D mRNA, complete cds. Anopheles gambiae 41,379
14-Jul-97 GB_GSS13: AQ475498 476 AQ475498 CITBI-E1-2589F13.TR
CITBI-E1 Homo sapiens genomic clone 2589F13, genomic Homo sapiens
40,511 23-Apr-99 survey sequence. GB_IN1: AF007166 1392 AF007166
Anopheles gambiae serine protease 14D mRNA, complete cds. Anopheles
gambiae 40 14-Jul-97 rxa01367 525 GB_EST28: AI489958 591 AI489958
EST248297 tomato ovary. TAMU Lycopersicon esculentum cDNA clone
Lycopersicon esculentum 38,186 29-Jun-99 cLED14O8, mRNA sequence.
GB_GSS13: AQ475498 476 AQ475498 CITBI-E1-2589F13.TR CITBI-E1 Homo
sapiens genomic clone 2589F13, genomic Homo sapiens 37,405
23-Apr-99 survey sequence. GB_EST28: AI489958 591 AI489958
EST248297 tomato ovary. TAMU Lycopersicon esculentum cDNA clone
cLED14O8, Lycopersicon esculentum 35,882 29-Jun-99 mRNA sequence.
rxa01370 rxa01372 614 GB_HTG5: AC011644 164746 AC011644 Homo
sapiens clone 14_K_21, *** SEQUENCING IN PROGRESS ***, Homo sapiens
33,715 5-Nov-99 8 unordered pieces. GB_HTG5: AC011644 164746
AC011644 Homo sapiens clone 14_K_21, *** SEQUENCING IN PROGRESS
***, Homo sapiens 35,821 5-Nov-99 8 unordered pieces. rxa01378 1878
GB_IN1: DM8R42I17 155168 AL121806 Drosophila melanogaster clone
BACR42I17. Drosophila melanogaster 36,373 10-OCT-1999 GB_IN2:
AC005714 177740 AC005714 Drosophila melanogaster, chromosome 2R,
region 58D4-58E2, BAC clone Drosophila melanogaster 36,234
01-MAY-1999 BACR48M13, complete sequence. GB_IN2: AC005639 188288
AC005639 Drosophila melanogaster, chromosome 2R, region 59E3-59F4,
BAC clone Drosophila melanogaster 36,275 6-Jan-99 BACR48M01,
complete sequence. rxa01379 1042 GB_HTG4: AC010031 132106 AC010031
Drosophila melanogaster chromosome 3L/70C1 clone RPCI98-2M20,
Drosophila melanogaster 35,368 16-OCT-1999 *** SEQUENCING IN
PROGRESS ***, 69 unordered pieces. GB_HTG4: AC010031 132106
AC010031 Drosophila melanogaster chromosome 3L/70C1 clone
RPCI98-2M20, Drosophila melanogaster 35,368 16-OCT-1999 ***
SEQUENCING IN PROGRESS ***, 69 unordered pieces. GB_HTG3: AC009932
68745 AC009932 Homo sapiens clone 114_O_12, LOW-PASS SEQUENCE
SAMPLING. Homo sapiens 36,337 05-OCT-1999 rxa01380 2322 GB_BA1:
SC5F2A 40105 AL049587 Streptomyces coelicolor cosmid 5F2A.
Streptomyces coelicolor 39,699 24-MAY-1999 GB_BA1: BPTEX 2701
X95386 B. pertussis tex gene. Bordetella pertussis 59,687 31-Jul-96
GB_BA1: SC5F2A 40105 AL049587 Streptomyces coelicolor cosmid 5F2A.
Streptomyces coelicolor 41,024 24-MAY-1999 rxa01384 1839 GB_GSS15:
AQ613816 598 AQ613816 HS_5118_B1_F06_T7A RPCI-11 Homo sapiens 39,3
15-Jun-99 Human Male BAC Library Homo sapiens genomic clone Plate =
694 Col = 11 Row = L, genomic survey sequence. GB_GSS15: AQ613816
598 AQ613816 HS_5118_B1_F06_T7A RPCI-11 Human Male BAC Library Homo
sapiens Homo sapiens 36,455 15-Jun-99 genomic clone Plate = 694 Col
= 11 Row = L, genomic survey sequence. rxa01390 780 GB_BA2:
CGL012293 2952 AJ012293 Corynebacterium glutamicum ilvD gene.
Corynebacterium 40,413 01-OCT-1999 glutamicum GB_PR4: AC006213
160754 AC006213 Homo sapiens, clone hRPK.15_A_1, complete sequence.
Homo sapiens 35,724 16-Jan-99 GB_PL2: ATF24G24 99856 AL049488
Arabidopsis thaliana DNA chromosome 4, BAC clone F24G24 (ESSA
project). Arabidopsis thaliana 35,925 27-Aug-99 rxa01391 813
GB_HTG2: AC006171 44733 AC006171 Homo sapiens chromosome 10 clone
LA10NC01_15_E_11 map 10q26.3, Homo sapiens 35,031 09-DEC-1998 ***
SEQUENCING IN PROGRESS ***, 3 unordered pieces. GB_HTG2: AC006171
44733 AC006171 Homo sapiens chromosome 10 clone LA10NC01_15_E_11
map 10q26.3, Homo sapiens 35,031 09-DEC-1998 *** SEQUENCING IN
PROGRESS ***, 3 unordered pieces. GB_HTG2: AC006171 44733 AC006171
Homo sapiens chromosome 10 clone LA10NC01_15_E_11 map 10q26.3, Homo
sapiens 38,035 09-DEC-1998 *** SEQUENCING IN PROGRESS ***, 3
unordered pieces. rxa01396 381 GB_BA2: AE000775 14358 AE000775
Aquifex aeolicus section 107 of 109 of the complete genome. Aquifex
aeolicus 43,085 25-MAR-1998 GB_EST26: AI329024 471 AI329024
a9c02ne.f1 Neurospora crassa evening cDNA library Neurospora crassa
cDNA Neurospora crassa 39,288 28-DEC-1998 clone a9c02ne 5', mRNA
sequence. GB_EST26: AI329043 401 AI329043 a9d06ne.f1 Neurospora
crassa evening cDNA library Neurospora crassa cDNA Neurospora
crassa 44,484 28-DEC-1998 clone a9d06ne 5', mRNA sequence. rxa01397
543 GB_BA2: AE000775 14358 AE000775 Aquifex aeolicus section 107 of
109 of the complete genome. Aquifex aeolicus 41,121 25-MAR-1998
GB_BA1: BSTMSPRS 3211 X16518 B. subtilis prs, tms, and ctc
(partial) genes for PRPP synthetase and two Bacillus subtilis
41,255 30-Sep-93 undefined gene products. GB_EST4: H21691 382
H21691 yI29b01.r1 Soares breast 3NbNBst Homo sapiens cDNA clone
IMAGE: 159625 Homo sapiens 35,407 6-Jul-95 5' similar to SP:
XPEC_CERAE P33194 POSSIBLE DNA-REPAIR PROTEIN XP-E;, mRNA sequence.
rxa01400 1623 GB_GSS11: AQ264714 353 AQ264714 CITBI-E1-2502C17.TR
CITBI-E1 Homo sapiens genomic clone 2502C17, Homo sapiens 40,227
27-OCT-1998 genomic survey sequence. GB_BA1: TFENTRA 2803 M58480
Thiobacillus ferrooxidans nitrogen metabolism regulator (ntrA)
gene, complete cds. Thiobacillus ferrooxidans 39,96 26-Apr-93
GB_BA1: NPSDHCDBA 5596 Y07709 N. pharaonis sdhC, sdhD, sdhB and
sdhA genes. Natronomonas pharaonis 38,003 2-Sep-96 rxa01401 384
GB_HTG4: AC006583 110000 AC006583 Homo sapiens chromosome 3p21.3
clone RPCI11-491D6, Homo sapiens 32,718 21-OCT-1999 *** SEQUENCING
IN PROGRESS ***, 90 unordered pieces. GB_HTG4: AC006583 110000
AC006583 Homo sapiens chromosome 3p21.3 clone RPCI11-491D6, ***
SEQUENCING IN Homo sapiens 32,718 21-OCT-1999 PROGRESS ***, 90
unordered pieces. GB_HTG4: AC011291 173585 AC011291 Homo sapiens
chromosome unknown clone NH0067G07, WORKING DRAFT Homo sapiens
33,596 29-OCT-1999 SEQUENCE, in unordered pieces. rxa01402 597
GB_BA1: CAJ10319 5368 AJ010319 Corynebacterium glutamicum amtP.
glnB, glnD genes and partial ftsY and srp genes. Corynebacterium
39,389 14-MAY-1999 glutamicum GB_HTG4: AC010066 187240 AC010066
Drosophila melanogaster chromosome
3L/72A4 clone RPCI98-25O1, Drosophila melanogaster 33,681
16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 70 unordered pieces.
GB_HTG4: AC010066 187240 AC010066 Drosophila melanogaster
chromosome 3L/72A4 clone RPCI98-25O1, Drosophila melanogaster
33,681 18-OCT-1999 *** SEQUENCING IN PROGRESS ***, 70 unordered
pieces. rxa01403 771 GB_BA1: SC6E10 23990 AL109661 Streptomyces
coelicolor cosmid 6E10. Streptomyces coelicolor 39,136 5-Aug-99
A3(2) GB_GSS12: AQ396728 608 AQ396728 mgxb0002E02f CUGI Rice Blast
BAC Library Magnaporthe grisea genomic Magnaporthe grisea 36,626
06-MAR-1999 clone mgxb0002E02f, genomic survey sequence. GB_BA1:
SC6E10 23990 AL109661 Streptomyces coelicolor cosmid 6E10.
Streptomyces coelicolor 41,403 5-Aug-99 A3(2) rxa01405 579 GB_PL2:
AF111709 52684 AF111709 Oryza sativa subsp. indica Retrosat 1
retrotransposon and Ty3-Gypsy type Retrosat 2 Oryza sativa subsp.
indica 34,888 26-Apr-99 retrotransposon, complete sequences; and
unknown genes. GB_GSS3: B88760 696 B88760 RPCI11-24L19.TPC RPCI-11
Homo sapiens genomic clone RPCI-11-24L19, Homo sapiens 37,204
9-Apr-99 genomic survey sequence. GB_STS: G52436 696 G52436
SHGC-85004 Human Homo sapiens STS genomic, sequence tagged site.
Homo sapiens 37,204 25-Jun-99 rxa01409 845 GB_HTG5: AC008019 190459
AC008019 Mus musculus, *** SEQUENCING IN PROGRESS ***, 16 unordered
pieces. Mus musculus 39,924 16-Nov-99 GB_PR4: AC006236 127593
AC006236 Homo sapiens chromosome 17, clone hCIT.162_E_12, complete
sequence. Homo sapiens 33,907 29-DEC-1998 GB_HTG5: AC008019 190459
AC008019 Mus musculus, *** SEQUENCING IN PROGRESS ***, 16 unordered
pieces. Mus musculus 40,819 16-Nov-99 rxa01413 723 GB_OV: AF038947
1617 AF038947 Ambystoma tigrinum red cone visual pigment mRNA,
complete cds. Ambystoma tigrinum 35,846 16-DEC-1998 GB BA1:
MSGB577COS 37770 L01263 M. leprae genomic dna sequence, cosmid
b577. Mycobacterium leprae 38,042 14-Jun-96 GB_PR3: AC002558 102064
AC002558 Homo sapiens chromosome 17, clone hRPC867C24, complete
sequence. Homo sapiens 36,82 31-OCT-1997 rxa01414 630 GB_PL1:
SC5610 37730 Z38060 S. cerevisiae chromosome IX sequence derived
from lambda clones 5610-5004. Saccharomyces cerevisiae 38,782
20-Aug-97 GB_PL1: YSCDIN1 2969 M58012 S. cerevisiae ribonucleotide
reductase DNA damage-inducible regulatory subunit Saccharomyces
cerevisiae 35,877 27-Apr-93 (DIN1) gene, 5' end. GB_EST18: AA689161
624 AA689161 ET2100 Trypanosoma brucei rhodesiense ZAP II library
Trypanosoma brucei Trypanosoma brucei 37,15 15-DEC-1997 rhodesiense
cDNA 5', mRNA sequence. rhodesiense rxa01417 720 GB_PL1: SC8419
30507 Z49701 S. cerevisiae chromosome IV cosmid 8419. Saccharomyces
cerevisiae 36,248 11-Aug-97 GB_PL1: SCPRP28G 2452 X56934 S.
cerevisiae PRP28 gene. Saccharomyces cerevisiae 45,036 9-Feb-95
GB_BA1: BACPEPFA 4654 M29035 B. subtilis bacillopeptidase F (bpr)
gene, complete cds. Bacillus subtilis 37,324 06-MAR-1995 rxa01421
rxa01422 1095 GB_EST24: AU033392 344 AU033392 AU033392
Dictyostelium discoideum SL (H. Urushihara) Dictyostelium
discoideum 38,953 28-Apr-99 Dictyostelium discoideum cDNA clone
SLA715, mRNA sequence. GB_EST14: AA399243 301 AA399243 zt57d02.s1
Soares_testis_NHT Homo sapiens cDNA clone IMAGE: Homo sapiens
45,183 12-Aug-97 726435 3' similar to SW: NIDO_HUMAN P14543 NIDOGEN
PRECURSOR;, mRNA sequence. GB_PR2: AC002037 53897 AC002037 Human
Chromosome 11 Overlapping Cosmids cSRL72g7 and cSRL140b8, complete
Homo sapiens 37,5 6-Aug-97 sequence. rxa01425 1008 GB_PR4: AC005908
196501 AC005908 Homo sapiens 12p13.3 BAC RPCI11-476M19 (Roswell
Park Cancer Homo sapiens 34,41 20-Jan-99 Institute Human BAC
Library) complete sequence. GB_PR4: AF111169 183916 AF111169 Homo
sapiens chromosome 14 BAC containing gene for KIAA0759 and other
Homo sapiens 40,635 19-Jul-99 possible new transcripts, complete
sequence. GB_HTG2: AC008284 146797 AC008284 Drosophila melanogaster
chromosome 3 clone BACR03M22 (D1000) RPCI-98 Drosophila
melanogaster 35,822 2-Aug-99 03.M.22 map 96C-96D strain y; cn bw
sp, *** SEQUENCING IN PROGRESS ***, 137 unordered pieces. rxa01429
741 GB_EST25: AI300084 635 AI300084 qn59f02.x1 NCI_CGAP_Kid5 Homo
sapiens cDNA Homo sapiens 37,753 1-Feb-99 clone IMAGE: 1902555 3',
mRNA sequence. GB_EST18: AA706612 949 AA706612 ah26c02.s1
Soares_parathyroid_tumor_NbHPA Homo sapiens cDNA Homo sapiens
37,361 12-Jan-99 clone 1239938 3', mRNA sequence. GB_EST35:
AI817084 598 AI817084 wj76g07.x1 NCI_CGAP_Lu19 Homo sapiens cDNA
clone IMAGE: Homo sapiens 38,627 24-Aug-99 2408796 3', mRNA
sequence. rxa01434 3075 GB_PL1: CAC49C10 37825 AL033497 C. albicans
cosmid Ca49C10. Candida albicans 34,724 10-Nov-98 GB_GSS3: B10423
1217 B10423 F19F22-T7 IGF Arabidopsis thaliana genomic clone
F19F22, genomic survey Arabidopsis thaliana 36,003 14-MAY-1997
sequence. GB_PL1: CAC49C10 37825 AL033497 C. albicans cosmid
Ca49C10. Candida albicans 33,794 10-Nov-98 rxa01439 669 GB_BA2:
AF049897 9196 AF049897 Corynebacterium glutamicum
N-acetylglutamylphosphate reductase (argC), ornithine
Corynebacterium 41,564 1-Jul-98 acetyltransferase (argJ),
N-acetylglutamate kinase (argB), acetylornithine transaminase
glutamicum (argD), ornithine carbamoyltransferase (argF), arginine
repressor (argR), argininosuccinate synthase (argG), and
argininosuccinate lyase (argH) genes, complete cds. GB_BA1:
CGARGCJBD 4355 X86157 C. glutamicum argC, argJ, argB, argD, and
argF genes. Corynebacterium 41,564 25-Jul-96 glutamicum GB_BA2:
AF049897 9196 AF049897 Corynebacterium glutamicum
N-acetylglutamylphosphate reductase (argC), ornithine
Corynebacterium 39,486 1-Jul-98 acetyltransferase (argJ),
N-acetylglutamate kinase (argB), acetylornithine transaminase
glutamicum (argD), ornithine carbamoyltransferase (argF), arginine
repressor (argR), argininosuccinate synthase (argG), and
argininosuccinate lyase (argH) genes, complete cds. rxa01440 1131
GB_PAT: E16763 2517 E16763 gDNA encoding aspartate transferase
(AAT). Corynebacterium 42,188 28-Jul-99 glutamicum GB_EST20:
AA870569 423 AA870569 vq23c09.r1 Barstead stromal cell line MPLRB8
Mus musculus cDNA clone Mus musculus 42,066 16-MAR-1998 IMAGE:
1095088 5' similar to TR: Q14468 Q14468 KIAA0047;, mRNA sequence.
GB_EST18: AA726390 436 AA726390 vu40b04.r1 Barstead mouse myotubes
MPLRB5 Mus musculus cDNA clone Mus musculus 41,228 2-Jan-98 IMAGE:
1193839 5', mRNA sequence. rxa01441 1152 GB_EST32: AV053763 252
AV053763 AV053763 Mus musculus pancreas C57BL/6J adult Mus musculus
cDNA Mus musculus 45,238 23-Jun-99 clone 1810028E06, mRNA sequence.
GB_EST20: AA870569 423 AA870569 vq23c09.r1 Barstead stromal cell
line MPLRB8 Mus musculus cDNA clone IMAGE: Mus musculus 39,643
16-MAR-1998 1095088 5' similar to TR: Q14468 Q14468 KIAA0047;, mRNA
sequence. GB_EST18: AA726390 436 AA726390 vu40b04.r1 Barstead mouse
myotubes MPLRB5 Mus musculus cDNA clone Mus musculus 39,953
2-Jan-98 IMAGE: 1193839 5', mRNA sequence. rxa01445 1116 GB_PR4:
AC007786 229061 AC007786 Homo sapiens chromosome 19, BAC 41855
(CIT-B-32o4), complete sequence. Homo sapiens 39,545 11-Jun-99
GB_PR3: AC003957 126581 AC003957 Homo sapiens chromosome 17, clone
hCIT.457_L_16, complete sequence. Homo sapiens 36,579 09-MAY-1998
GB_OV: AF108420 46626 AF108420 Fugu rubripes prohormone convertase
PACE4 (PACE4) gene, partial cds; and Fugu rubripes 39,187
17-MAR-1999 1-aminocyclopropane-carboxilate synthase (ACC),
recombination-activating protein 1 (RAG1), and
recombination-activating protein 2 (RAG2) genes, complete cds.
rxa01447 972 GB_PL2: AF049112 1436 AF049112 Zea mays
retrotransposon Cinful prpol mRNA, partial cds. Zea mays 38,268
1-Feb-99 GB_EST36: AV190070 360 AV190070 AV190070 Yuji Kohara
unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis
elegans 40,39 22-Jul-99 Caenorhabditis elegans cDNA clone yk566e10
5', mRNA sequence. GB_EST9: AA103228 477 AA103228 mo22h07.r1 Life
Tech mouse embryo 13 5dpc 10666014 Mus musculus cDNA clone Mus
musculus 40,411 29-OCT-1996 IMAGE: 554365 5' similar to gb: J00068
ACTIN, ALPHA SKELETAL MUSCLE (HUMAN); gb: M12866 Mouse skeletal
muscle actin mRNA, complete cds (MOUSE);, mRNA sequence. rxa01448
1290 GB_BA1: CGFDA 3371 X17313 Corynebacterium glutamicum fda gene
for fructose-bisphosphate aldolase Corynebacterium 100 12-Sep-93
(EC 4.1.2.13). glutamicum GB_PL2: ENU75428 4443 U75428 Emericella
nidulans acid trehalase precursor (treA) gene, complete cds.
Emericella nidulans 36,271 15-MAY-1997 GB_BA1: CGFDA 3371 X17313
Corynebacterium glutamicum fda gene for fructose-bisphosphate
aldolase Corynebacterium 37,872 12-Sep-93 (EC 4.1.2.13). glutamicum
rxa01452 402 GB_BA1: MTV017 67200 AL021897 Mycobacterium
tuberculosis H37Rv complete genome; segment 48/162. Mycobacterium
57,246 24-Jun-99 tuberculosis GB_BA1: MLCB1222 34714 AL049491
Mycobacterium leprae cosmid B1222. Mycobacterium leprae 34,872
27-Aug-99 GB_BA2: S71532 914 S71532 che = cholesterol esterase
[Streptomyces lavendulae, H646-SY2, Genomic, 914 nt]. Streptomyces
lavendulae 38,701 8-Nov-94 rxa01456 645 GB_GSS3: B16150 663 B16150
347A15.TP CIT978SKA1 Homo sapiens genomic clone A-347A15, genomic
Homo sapiens 34,394 4-Jun-98 survey sequence. GB_HTG3: AC004157
132090 AC004157 Plasmodium falciparum chromosome 12 clone 3D7, ***
SEQUENCING IN Plasmodium falciparum 34,165 23-Sep-99 PROGRESS ***,
9 unordered pieces. GB_HTG3: AC004157 132090 AC004157 Plasmodium
falciparum chromosome 12 clone 3D7, *** SEQUENCING IN Plasmodium
falciparum 34,165 23-Sep-99 PROGRESS ***, 9 unordered pieces.
rxa01457 798 GB_HTG3: AC011009 158335 AC011009 Homo sapiens clone
2_I_22, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 39,49 29-Sep-99
GB_HTG3: AC011009 158335 AC011009 Homo sapiens clone 2_I_22,
LOW-PASS SEQUENCE SAMPLING. Homo sapiens 39,49 29-Sep-99 GB_HTG3:
AC011009 158335 AC011009 Homo sapiens clone 2_I_22, LOW-PASS
SEQUENCE SAMPLING. Homo sapiens 39,125 29-Sep-99 rxa01459 933
GB_HTG3: AC008670 113564 AC008670 Homo sapiens chromosome 5 clone
CIT978SKB_36O1, *** SEQUENCING IN Homo sapiens 39,022 3-Aug-99
PROGRESS ***, 43 unordered pieces. GB_HTG3: AC008670 113564
AC008670 Homo sapiens chromosome 5 clone CIT978SKB_36O1, ***
SEQUENCING IN Homo sapiens 39,022 3-Aug-99 PROGRESS ***, 43
unordered pieces. GB_IN2: CELT05A8 33896 AF040652 Caenorhabditis
elegans cosmid T05A8. Caenorhabditis elegans 35,699 16-Jun-99
rxa01460 417 GB_HTG3: AC009186 48600 AC009186 Homo sapiens
chromosome 5 clone CIT978SKB_148I14, Homo sapiens 41,278
07-OCT-1999 *** SEQUENCING IN PROGRESS ***, 3 ordered pieces.
GB_HTG3: AC009186 48600 AC009186 Homo sapiens chromosome 5 clone
CIT978SKB_148I14, *** SEQUENCING Homo sapiens 41,278 07-OCT-1999 IN
PROGRESS ***, 3 ordered pieces. GB_HTG3: AC009186 48600 AC009186
Homo sapiens chromosome 5 clone CIT978SKB_148I14, *** SEQUENCING
Homo sapiens 35,162 07-OCT-1999 IN PROGRESS ***, 3 ordered pieces.
rxa01463 1287 GB_PR3: HS326L13 127247 Z82170 Human DNA sequence
from PAC 326L13 containing brain-4 mRNA ESTs Homo sapiens 37,956
23-Nov-99 and polymorphic CA repeat. GB_HTG1: HS439A6 49379
AL031723 Homo sapiens chromosome 16 clone LA16-439A6, ***
SEQUENCING Homo sapiens 38,035 23-Nov-99 IN PROGRESS ***, in
unordered pieces. GB_HTG1: HS439A6 49379 AL031723 Homo sapiens
chromosome 16 clone LA16-439A6, *** SEQUENCING IN Homo sapiens
38,035 23-Nov-99 PROGRESS ***, in unordered pieces. rxa01469 1155
GB_EST31: AI701691 349 AI701691 we81c04.x1 Soares_NFL_T_GBC_S1 Homo
sapiens 39,806 3-Jun-99 Homo sapiens cDNA clone IMAGE: 2347494 3'
similar to gb: L19686_rna1 MACROPHAGE MIGRATION INHIBITORY FACTOR
(HUMAN):, mRNA sequence. GB_EST15: AA480256 389 AA480256 ne31f04.s1
NCI_CGAP_Co3 Homo sapiens cDNA clone IMAGE: 898975 3' similar Homo
sapiens 42,705 14-Aug-97 to gb: L19686_rna1 MACROPHAGE MIGRATION
INHIBITORY FACTOR (HUMAN);, mRNA sequence. GB_IN2: AF153269 1308
AF153269 Tetrahymena thermophila dynein heavy chain (DYH10) gene,
partial cds. Tetrahymena thermophila 32,489 10-Jun-99 rxa01470 549
GB_PL2: ATF3L17 94319 AL080283 Arabidopsis thaliana DNA chromosome
4, BAC clone F3L17 (ESSA project). Arabidopsis thaliana 37,615
24-Jun-99 GB_PL2: ATF3L17 94319 AL080283 Arabidopsis thaliana DNA
chromosome 4, BAC clone F3L17 (ESSA project). Arabidopsis thaliana
35,946 24-Jun-99 rxa01471 930 GB_EST11: AA233898 460 AA233898
zr49b12.s1 Soares_NhHMPu_S1 Homo sapiens cDNA Homo sapiens 40,57
6-Aug-97 clone IMAGE: 666719 3', mRNA sequence. GB_EST11: AA234033
428 AA234033 zr49b12.r1 Soares_NhHMPu_S1 Homo sapiens cDNA clone
IMAGE: Homo sapiens 36,277 6-Aug-97 666719 5' similar to contains
Alu repetitive element;, mRNA sequence. GB_PL2: AF084971 1874
AF084971 Catharanthus roseus G-box binding protein 1 (GBF1) mRNA,
complete cds. Catharanthus roseus 36,821 7-Jul-99 rxa01472 rxa01473
888 GB_PL2: AC002329 76170 AC002329 DNA sequence of Arabidopsis
thaliana BAC F5J6 from chromosome IV, Arabidopsis thaliana 35,78
18-Nov-97 complete sequence. GB_HTG3: AC009485 190706 AC009485 Homo
sapiens clone NH0324G03, *** SEQUENCING IN PROGRESS ***, Homo
sapiens 39,649 04-OCT-1999 6 unordered pieces. GB_HTG3: AC009485
190706 AC009485 Homo sapiens clone NH0324G03, *** SEQUENCING IN
PROGRESS ***, Homo sapiens 39,649 04-OCT-1999 6 unordered pieces.
rxa01474 669 GB_PR2: HSP373C6 85654 AL022393 Homo sapiens DNA
sequence from P1 p373c6 on chromosome Homo sapiens 33,934 22-Nov-99
6p21.31-21.33. Contains zinc finger proteins, pseudogenes, ESTs
and
STS. GB_EST4: H30893 485 H30893 yp43e11.r1 Soares retina N2b5HR
Homo sapiens cDNA clone IMAGE: 190220 5' Homo sapiens 37,866
16-Aug-95 similar to contains Alu repetitive element;, mRNA
sequence. GB_PL2: ATAC005398 80238 AC005398 Arabidopsis thaliana
chromosome II BAC T6B13 genomic sequence, complete Arabidopsis
thaliana 38,64 30-OCT-1998 sequence. rxa01475 549 GB_PL1: AB024028
70952 AB024028 Arabidopsis thaliana genomic DNA, chromosome 3, TAC
clone: K1G2, Arabidopsis thaliana 40,52 20-Nov-99 complete
sequence. GB_HTG2: AC007940 159279 AC007940 Homo sapiens clone
44_C_14, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,044
1-Jul-99 12 unordered pieces. GB_HTG2: AC007940 159279 AC007940
Homo sapiens clone 44_C_14, *** SEQUENCING IN PROGRESS ***, Homo
sapiens 36,044 1-Jul-99 12 unordered pieces. rxa01476 465 GB_PL1:
AB009087 1074 AB009087 Chlamydomonas sp. mRNA for alternative
oxidase, partial cds. Chlamydomonas sp. 38,596 05-DEC-1997 GB_PL1:
AB009087 1074 AB009087 Chlamydomonas sp. mRNA for alternative
oxidase, partial cds. Chlamydomonas sp. 39,519 05-DEC-1997 rxa01479
363 GB_HTG1: HSJ136J15 148579 AL118496 Homo sapiens chromosome X
clone RP1-136J15, *** SEQUENCING Homo sapiens 39,886 23-Nov-99 IN
PROGRESS ***, in unordered pieces. GB_HTG1: HSJ136J15 148579
AL118496 Homo sapiens chromosome X clone RP1-136J15, *** SEQUENCING
Homo sapiens 39,886 23-Nov-99 IN PROGRESS ***, in unordered pieces.
GB_HTG2: AC007579 134344 AC007579 Drosophila melanogaster
chromosome 2 clone BACR07M03 (D607) RPCI-98 Drosophila melanogaster
39,266 2-Aug-99 07.M.3 map 53A-53B strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 108 unordered pieces. rxa01484 669
GB_PR3: AF064858 193387 AF064858 Homo sapiens chromosome 21q22.3
BAC 28F9, complete sequence. Homo sapiens 38,281 2-Jun-98 GB_GSS10:
AQ207755 496 AQ207755 HS_3026_B1_G04_T7 CIT Approved Human Homo
sapiens 37,15 18-Sep-98 Genomic Sperm Library D Homo sapiens
genomic clone Plate = 3026 Col = 7 Row = N, genomic survey
sequence. GB_PR3: AF064858 193387 AF064858 Homo sapiens chromosome
21q22.3 BAC 28F9, complete sequence. Homo sapiens 38,379 2-Jun-98
rxa01485 2175 GB_IN1: CEY50E8A 61864 AL117200 Caenorhabditis
elegans cosmid Y50E8A, complete sequence. Caenorhabditis elegans
39,617 19-Nov-99 GB_IN1: CEY50E8A 61864 AL117200 Caenorhabditis
elegans cosmid Y50E8A, complete sequence. Caenorhabditis elegans
34,349 19-Nov-99 GB_PL1: AB028606 61510 AB028606 Arabidopsis
thaliana genomic DNA, chromosome 5, BAC clone: F16F17, Arabidopsis
thaliana 34,858 20-Nov-99 complete sequence. rxa01488 1071 GB_BA1:
CGPROMF10 60 X90358 C. glutamicum DNA for promoter fragment F10.
Corynebacterium 65 4-Nov-96 glutamicum GB_EST10: AA183656 465
AA183656 mt20f08.r1 Soares mouse 3NbMS Mus musculus cDNA clone
IMAGE: 621639 Mus musculus 35,333 17-Feb-97 5' similar to WP:
T02C12.2 CE01062;, mRNA sequence. GB_EST9: AA110912 309 AA110912
mm02c01.r1 Stratagene mouse kidney (#937315) Mus musculus cDNA
clone IMAGE: Mus musculus 37,662 4-Feb-97 520320 5' similar to WP:
T02C12.2 CE01062;, mRNA sequence. rxa01492 927 GB_EST16: AA589576
567 AA589576 vl49b06.s1 Stratagene mouse skin (#937313) Mus
musculus cDNA Mus musculus 34,104 16-Sep-97 clone IMAGE: 975539 3'
similar to gb: M63488 REPLICATION PROTEIN A 70 KD DNA-BINDING
SUBUNIT (HUMAN);, mRNA sequence. GB_EST28: AU051490 865 AU051490
AU051490 Sugano mouse brain mncb Mus musculus cDNA clone MNCb-2105
5', Mus musculus 29,837 18-MAR-1999 mRNA sequence. GB_EST32:
AI738234 609 AI738234 606044C01.x2 606 - Ear tissue cDNA library
from Schmidt lab Zea mays cDNA, Zea mays 38,291 16-Jun-99 mRNA
sequence. rxa01494 1119 GB_PR4: AC007106 172188 AC007106 Homo
sapiens chromosome 4 clone C0383J20 map 4p16, complete sequence.
Homo sapiens 35,108 2-Jun-99 GB_BA2: AE001093 14097 AE001093
Archaeoglobus fulgidus section 14 of 172 of the complete genome.
Archaeoglobus fulgidus 38,113 15-DEC-1997 GB_PR4: AC007106 172188
AC007106 Homo sapiens chromosome 4 clone C0383J20 map 4p16,
complete sequence. Homo sapiens 34,657 2-Jun-99 rxa01497 1041
GB_BA2: SCJ1 36925 AL109962 Streptomyces coelicolor cosmid J1.
Streptomyces coelicolor 50,722 24-Sep-99 A3(2) GB_BA1: MTY20B11
36330 Z95121 Mycobacterium tuberculosis H37Rv complete genome;
segment 139/162. Mycobacterium 40,238 17-Jun-98 tuberculosis
GB_BA1: PAU12891 4062 U12891 Pseudomonas aeruginosa PAO substrain
OT684 pyoverdine gene transcriptional Pseudomonas aeruginosa 39,856
03-OCT-1996 regulator PvdS (pvdS) gene, complete cds. rxa01501 411
GB_PAT: I78757 2203 I78757 Sequence 13 from patent U.S. Pat. No.
5693781. Unknown. 61,364 3-Apr-98 GB_PAT: I92046 2203 I92046
Sequence 13 from patent U.S. Pat. No. 5726299. Unknown. 61,364
01-DEC-1998 GB_PR4: AC002427 101098 AC002427 Homo sapiens BAC clone
GS011E15 from 5q31, complete sequence. Homo sapiens 42,25
02-DEC-1998 rxa01504 732 GB_HTG3: AC008954 23046 AC008954 Homo
sapiens chromosome 5 clone CITB-H1_2340N2, *** SEQUENCING Homo
sapiens 37,83 3-Aug-99 IN PROGRESS ***, 51 unordered pieces.
GB_HTG3: AC008954 23046 AC008954 Homo sapiens chromosome 5 clone
CITB-H1_2340N2, *** SEQUENCING Homo sapiens 37,83 3-Aug-99 IN
PROGRESS ***, 51 unordered pieces. GB_BA1: QPHQSOP 4068 L28041
Plasmid QpH1 (from Coxiella burnetii) qsopA and qsopB genes,
promoter region. Plasmid QpH1 37,517 14-Jul-95 rxa01505 621 GB_SY:
SYNM13GAL 66 M10216 Bacteriophage M13gt102 N-terminal
beta-galactosidase gene (lac+ phenotype). unidentified cloning
vector 62,121 27-Apr-93 GB_SY: SYNM13GAL 66 M10216 Bacteriophage
M13gt102 N-terminal beta-galactosidase gene (lac+ phenotype).
unidentified cloning vector 62,121 27-Apr-93 GB_BA2: BJU56817 2892
U56817 Bradyrhizobium japonicum aconitase (acnA) gene, complete
cds. Bradyrhizobium japonicum 40,214 13-Nov-96 rxa01506 534 GB_BA1:
MTCY98 31225 Z83860 Mycobacterium tuberculosis H37Rv complete
genome; segment 103/162. Mycobacterium 38,274 17-Jun-98
tuberculosis GB_BA1: MTCY98 31225 Z83860 Mycobacterium tuberculosis
H37Rv complete genome; segment 103/162. Mycobacterium 33,71
17-Jun-98 tuberculosis rxa01507 546 GB_RO: D89731 1815 D89731
Rattus norvegicus mRNA for AIM-1, complete cds. Rattus norvegicus
38,125 7-Feb-99 GB_RO: D89731 1815 D89731 Rattus norvegicus mRNA
for AIM-1, complete cds. Rattus norvegicus 34,6 7-Feb-99 rxa01518
rxa01519 870 GB_HTG2: AC007929 123885 AC007929 Drosophila
melanogaster chromosome 3 clone BACR05C11 (D759) Drosophila
melanogaster 34,075 2-Aug-99 RPCI-98 05.C.11 map 95A-95C strain y;
cn bw sp, *** SEQUENCING IN PROGRESS ***, 85 unordered pieces.
GB_HTG2: AC007929 123885 AC007929 Drosophila melanogaster
chromosome 3 clone BACR05C11 (D759) RPCI-98 Drosophila melanogaster
34,075 2-Aug-99 05.C.11 map 95A-95C strain y; cn bw sp, ***
SEQUENCING IN PROGRESS***, 85 unordered pieces. GB_PL2: AC011437
95310 AC011437 Arabidopsis thaliana chromosome III BAC F7O18
genomic sequence, Arabidopsis thaliana 37,28 2-Nov-99 complete
sequence. rax01520 rxa01523 1074 GB_GSS11: AQ270206 389 AQ270206
HS_2037_A1_G10_T7 CIT Homo sapiens 38,046 3-Nov-98 Approved Human
Genomic Sperm Library D Homo sapiens genomic clone Plate = 2037 Col
= 19 Row = M, genomic survey sequence. GB_GSS14: AQ588624 480
AQ588624 CITBI-E1-2643C9.TF CITBI-E1 Homo sapiens genomic clone
2643C9, Homo sapiens 36,875 7-Jun-99 genomic survey sequence.
GB_HTG1: CEY80D3 245017 AL020988 Caenorhabditis elegans chromosome
V clone Y80D3, *** SEQUENCING Caenorhabditis elegans 35,646
6-Sep-99 IN PROGRESS ***, in unordered pieces. rxa01525 1845
GB_PR3: HS560B9 99074 Z98751 Human DNA sequence from PAC 560B9 on
chromosome 1q24-1q25. Contains Homo sapiens 37,981 23-Nov-99
profilin-like pseudogene, 60S ribosomal protein L4 pseudogene RNA
binding protein, ESTs, GSS. GB_PR3: HS560B9 99074 Z98751 Human DNA
sequence from PAC 560B9 on chromosome 1q24-1q25. Contains Homo
sapiens 37,982 23-Nov-99 profilin-like pseudogene, 60S ribosomal
protein L4 pseudogene RNA binding protein, ESTs, GSS. rxa01527
rxa01536 1365 GB_HTG3: AC010745 193862 AC010745 Homo sapiens clone
NH0549D18, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,277
21-Sep-99 30 unordered pieces. GB_HTG3: AC010745 193862 AC010745
Homo sapiens clone NH0549D18, *** SEQUENCING IN PROGRESS ***, Homo
sapiens 35,277 21-Sep-99 30 unordered pieces. GB_HTG3: AC010745
193862 AC010745 Homo sapiens clone NH0549D18, *** SEQUENCING IN
PROGRESS ***, Homo sapiens 35,958 21-Sep-99 30 unordered pieces.
rxa01539 2289 GB_BA1: CGPROMF10 60 X90358 C. glutamicum DNA for
promoter fragment F10. Corynebacterium 61,667 4-Nov-96 glutamicum
GB_HTG3: AC011577 151996 AC011577 Homo sapiens clone 12_P_19,
LOW-PASS SEQUENCE SAMPLING. Homo sapiens 35,554 07-OCT-1999
GB_HTG3: AC011577 151996 AC011577 Homo sapiens clone 12_P_19,
LOW-PASS SEQUENCE SAMPLING. Homo sapiens 35,554 07-OCT-1999
rxa01540 825 GB_EST10: AA152819 491 AA152819 mq67e04.r1 Soares
2NbMT Mus musculus cDNA clone IMAGE: 583806 5', Mus musculus 39,04
18-Feb-97 mRNA sequence. GB_EST29: AI616027 481 AI616027 mq67e04.y1
Soares 2NbMT Mus musculus cDNA clone IMAGE: 583806 5', Mus musculus
36,688 21-Apr-99 mRNA sequence. GB_GSS6: AQ843942 468 AQ843942
LMAJFV1_Im03d08.x2 Leishmania major FV1 random genomic library
Leishmania major 40,899 04-OCT-1999 Leishmania major genomic clone
LMAJFV1_Im03d08 3', genomic survey sequence. rxa01543 2889 GB_BA2:
ECOUW67_0 110000 U18997 Escherichia coli K-12 chromosomal region
from 67.4 to 76.0 minutes. Escherichia coli 36,618 15-Sep-99
GB_BA2: ECOUW67_0 110000 U18997 Escherichia coli K-12 chromosomal
region from 67.4 to 76.0 minutes. Escherichia coli 38,415 15-Sep-99
GB_BA2: AE000397 14820 AE000397 Escherichia coli K-12 MG1655
section 287 of 400 of the complete genome. Escherichia coli 37,594
12-Nov-98 rxa01544 723 GB_EST37: AI977486 479 AI977486 EST272080
Schistosoma mansoni male, Phil LoVerde/Joe Schistosoma mansoni
44,158 27-Aug-99 Merrick Schistosoma mansoni cDNA clone SMMAM80 5'
end, mRNA sequence. GB_VI: AF056119 564 AF056119 HIV-1 isolate z560
from Zimbabwe, envelope glycoprotein V3-V5 region (env) gene, Human
immunodeficiency 35,874 26-Sep-98 partial cds. virus type 1 GB_VI:
AF056119 564 AF056119 HIV-1 isolate z560 from Zimbabwe, envelope
glycoprotein V3-V5 region (env) gene, Human immunodeficiency 37,229
26-Sep-98 partial cds. virus type 1 rxa01545 1374 GB_HTG1:
CEY53C10_1 110000 Z93340 Caenorhabditis elegans chromosome I clone
Y53C10, *** SEQUENCING Caenorhabditis elegans 36,885 4-Nov-98 IN
PROGRESS ***, in unordered pieces. GB_HTG1: CEY53C10_1 110000
Z93340 Caenorhabditis elegans chromosome I clone Y53C10, ***
SEQUENCING IN Caenorhabditis elegans 36,885 4-Nov-98 PROGRESS ***,
in unordered pieces. GB_HTG1: CEY47H9_1 110000 Z92853
Caenorhabditis elegans chromosome I clone Y47H9, *** SEQUENCING IN
Caenorhabditis elegans 30,285 4-Sep-98 PROGRESS ***, in unordered
pieces. rxa01546 819 GB_GSS3: B58207 420 B58207 CIT-HSP-2012C11.TR
CIT-HSP Homo sapiens genomic clone 2012C11, genomic Homo sapiens
45,228 20-Jun-98 survey sequence. GB_IN1: HAU02678 623 U02578
Helicoverpa armigera mitochondrion D-loop, partial 12S rRNA gene,
and Mitochondrion Helicoverpa 37,5 27-OCT-1993 partial tRNA-Met
gene. armigera GB_EST19: AA769027 473 AA769027 oa78g01.s1
NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE: 1318416 3' Homo
sapiens 39,583 28-Jan-98 similar to TR: Q92617 Q92617 MYELOBLAST
KIAA0220;, mRNA sequence. rxa01547 786 GB_EST26: AU002373 837
AU002373 AU002373 Bombyx mori p50(Daizo) Bombyx mori cDNA clone
mg0832, Bombyx mori 37,698 15-Jan-99 mRNA sequence. GB_EST30:
AV025617 494 AV025617 AV025617 Mus musculus adult C57BL/6J lung Mus
musculus cDNA clone Mus musculus 38,316 31-Aug-99 1200014J18, mRNA
sequence. GB_EST26: AU002373 837 AU002373 AU002373 Bombyx mori
p50(Daizo) Bombyx mori cDNA clone Bombyx mori 36,767 15-Jan-99
mg0832, mRNA sequence. rxa01548 1131 GB_IN1: PFARBPCA 8841 M88097
Plasmodium vivax retyculocyte binding protein 1 gene, complete cds.
Plasmodium vivax 37,077 26-Apr-93 GB_PAT: I55034 1985 I55034
Sequence 2 from patent U.S. Pat. No. 5646247. Unknown. 38,25
07-OCT-1997 GB_OV: GGNEUROMP 1112 Y09597 G. gallus mRNA for NeuroM
protein. Gallus gallus 37,104 15-OCT-1997 rxa01549 1727 GB_PR4:
HSLONPG01 2443 AF059296 Homo sapiens LON protease (LON) gene,
nuclear gene encoding Homo sapiens 39,401 11-Apr-99 mitochondrial
protein, exon 1. GB_EST33: AI770254 555 AI770254 SAL2.F12 Black
Tiger Shrimp Whole Cephalothorax UniZap library Penaeus monodon
40,325 28-Jun-99 Penseus monodon cDNA clone SAL2.F12 5' similar to
muscle myosin heavy chain, mRNA sequence. GB_PR1: HSU02389 3179
U02389 Human hLON ATP-dependent protease mRNA, nuclear gene
encoding Homo sapiens 38,868 27-Jan-95 mitochondrial protein,
complete cds. rxa01552 1101 GB_HTG4: AC011192 144277 AC011192 Homo
sapiens clone hRPK.53_A_1, *** SEQUENCING IN Homo sapiens 36,296
19-OCT-1999 PROGRESS ***, 9 unordered pieces. GB_HTG4: AC011192
144277 AC011192 Homo sapiens clone hRPK.53_A_1, *** SEQUENCING IN
Homo sapiens 36,296 19-OCT-1999 PROGRESS ***, 9 unordered pieces.
GB_HTG3: AC011203 70518 AC011203 Homo sapiens chromosome 3 clone
78_O_24 map 3, LOW-PASS Homo sapiens 36,44 03-OCT-1999 SEQUENCE
SAMPLING. rxa01554 2265 GB_EST27: AA957437 340 AA957437
UI-R-E1-fy-g-02-0-UI.s1 UI-R-E1 Rattus norvegicus cDNA clone Rattus
norvegicus 39,039 4-Jul-99
UI-R-E1-fy-g-02-0-UI 3', mRNA sequence. GB_PL2: SPBC19G7 37727
AL021839 S. pombe chromosome II cosmid c19G7. Schizosaccharomyces
36,991 17-Nov-99 pombe GB_PL1: HVPROTZ 703 X05902 Barley mRNA
fragment for protein Z. Hordeum vulgare 36,39 13-Jul-95 rxa01557
939 GB_EST24: AI167051 429 AI167051 xylem.est.822 Poplar xylem
Lambda ZAPII library Populus balsamifera subsp. Populus balsamifera
40,326 03-DEC-1998 trichocarpa cDNA 5', mRNA sequence. subsp.
trichocarpa GB_PL2: AC007259 97146 AC007259 Arabidopsis thaliana
chromosome I BAC T28P6 genomic sequence, complete Arabidopsis
thaliana 34,442 17-Aug-99 sequence. GB_PL2: AC007259 97146 AC007259
Arabidopsis thaliana chromosome I BAC T28P6 genomic sequence,
complete Arabidopsis thaliana 34,967 17-Aug-99 sequence. rxa01560
rxa01574 1158 GB_PR3: AC005242 160262 AC005242 Homo sapiens
chromosome 17, clone hRPK.118_F_13, complete sequence. Homo sapiens
35,727 22-Jul-98 GB_PR3: AC005242 160262 AC005242 Homo sapiens
chromosome 17, clone hRPK.118_F_13, complete sequence. Homo sapiens
33,969 22-Jul-98 GB_HTG2: AC007604 167373 AC007604 Homo sapiens
chromosome 16 clone 344L6, *** SEQUENCING IN PROGRESS***, Homo
sapiens 36,028 20-MAY-1999 85 unordered pieces. rxa01575 1143
GB_PR4: AC004738 147404 AC004738 Homo sapiens Chromosome 15q11-q13
PAC clone pDJ351h23 from the Prader- Homo sapiens 37,312 25-Nov-98
Willi/Angelman Syndrome region, complete sequence. GB_PR3: AC005250
94336 AC005250 Homo sapiens BAC clone RG318M05 from 7q22-q31.1,
complete sequence. Homo sapiens 38,201 3-Jul-98 GB_GSS11: AQ300376
487 AQ300376 HS_2206_A2_D05_MR CIT Approved Human Genomic Sperm
Library D Homo sapiens 35,345 16-DEC-1998 Homo sapiens genomic
clone Plate = 2206 Col = 10 Row = G, genomic survey sequence.
rxa01577 498 GB_BA1: MTY15C10 33050 Z95436 Mycobacterium
tuberculosis H37Rv complete genome; segment 154/162. Mycobacterium
58,385 17-Jun-98 tuberculosis GB_BA2: AF030975 2511 AF030975
Aeromonas salmonicida chaperonin GroES and chaperonin GroEL genes,
Aeromonas salmonicida 41,322 2-Apr-98 complete cds. GB_EST7: W33355
488 W33355 mb97g01.r1 Soares mouse p3NMF 19.5 Mus musculus cDNA
clone IMAGE: Mus musculus 40,23 11-Sep-96 337392 5' similar to gb:
X58196_cds1 M. musculus H19 mRNA (MOUSE);, mRNA sequence. rxa01579
507 GB_GSS1: GGA300114 662 AJ231964 Gallus gallus anonymous
sequence from Cosmid mapping to chicken chromosome 3 Gallus gallus
38,023 25-Aug-98 (Cosmid 30 - Contig 14), genomic survey sequence.
GB_GSS1: GGA300114 662 AJ231964 Gallus gallus anonymous sequence
from Cosmid mapping to chicken chromosome 3 Gallus gallus 38,608
25-Aug-98 (Cosmid 30 - Contig 14), genomic survey sequence.
rxa01585 750 GB_PR4: AC004815 120538 AC004815 Homo sapiens clone
82F9, complete sequence. Homo sapiens 35,383 8-Sep-99 GB_PR2:
AP000151 100000 AP000151 Homo sapiens genomic DNA, chromosome
21q22.2, DSCR region, clone D47-S479, Homo sapiens 39,722 20-Nov-99
segment 3/16, complete sequence. GB_PR2: AP000151 100000 AP000151
Homo sapiens genomic DNA, chromosome 21q22.2, DSCR region, clone
D47-S479, Homo sapiens 34,683 20-Nov-99 segment 3/16, complete
sequence. rxa01586 392 GB_GSS5: AQ791385 522 AQ791385
HS_5268_A2_C05_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo
sapiens 43,235 3-Aug-99 genomic clone Plate = 844 Col = 10 Row = E,
genomic survey sequence. GB_EST15: AA463774 255 AA463774 aa09f10.r1
Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE: 812779 5' Homo
sapiens 42,045 10-Jun-97 similar to gb: X07868_rna1 PUTATIVE
INSULIN-LIKE GROWTH FACTOR II ASSOCIATED (HUMAN); contains element
PTR7 repetitive element;, mRNA sequence. GB_PR1: AP000010 100000
AP000010 Homo sapiens genomic DNA of 21q22.2 Down Syndrome region,
segment 3/13. Homo sapiens 38,684 24-Apr-99 rxa01590 rxa01592 1425
GB_HTG2: AC008163 135300 AC008163 Homo sapiens clone NH0005B09, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 34,141 31-Jul-99 1
unordered pieces. GB_HTG2: AC008163 135300 AC008163 Homo sapiens
clone NH0005B09, *** SEQUENCING IN PROGRESS ***, Homo sapiens
34,141 31-Jul-99 1 unordered pieces. GB_HTG3: AC009231 181006
AC009231 Homo sapiens clone NH0350124, *** SEQUENCING IN PROGRESS
***, Homo sapiens 36,767 6-Aug-99 2 unordered pieces. rxa01595 1083
GB_BA1: MTCI125 37432 Z98268 Mycobacterium tuberculosis H37Rv
complete genome; segment 76/162. Mycobacterium 57,955 17-Jun-98
tuberculosis GB_BA1: MTHYPROT 2544 X98295 M. Tuberculosis TlyA
gene. Mycobacterium 57,955 2-Jun-98 tuberculosis GB_BA1: U00021
39193 U00021 Mycobacterium leprae cosmid L247. Mycobacterium leprae
35,261 29-Sep-94 rxa01597 1305 GB_HTG3: AC009462 103046 AC009462
Drosophila melanogaster chromosome 3 clone BACR27G04 (D985) RPCI-98
27.G.4 Drosophila melanogaster 38,898 30-Aug-99 map 90E--90E strain
y; cn bw sp, *** SEQUENCING IN PROGRESS***, 88 unordered pieces.
GB_HTG3: AC009462 103046 AC009462 Drosophila melanogaster
chromosome 3 clone BACR27G04 (D985) RPCI-98 27.G.4 Drosophila
melanogaster 38,898 30-Aug-99 map 90E--90E strain y; cn bw sp, ***
SEQUENCING IN PROGRESS***, 88 unordered pieces. GB_HTG2: AC006889
267118 AC006889 Caenorhabditis elegans clone Y65B4, *** SEQUENCING
IN PROGRESS ***, Caenorhabditis elegans 36,236 26-Feb-99 6
unordered pieces. rxa01598 1086 GB_EST2: R02663 397 R02663
ye80a04.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone
IMAGE: Homo sapiens 36,272 31-MAR-1995 124014 5', mRNA sequence.
GB_EST6: W03663 346 W03663 za65b08.r1 Soares fetal liver spleen
1NFLS Homo sapiens cDNA clone IMAGE: Homo sapiens 42,775 19-Apr-96
297399 5', mRNA sequence. GB_IN2: AC007765 163403 AC007765
Drosophila melanogaster, chromosome 2L, region 23C1-23C5, P1 clones
DS02190 Drosophila melanogaster 38,351 9-Jun-99 and DS00906,
complete sequence. rxa01600 792 GB_STS: G39530 822 G39530 Z22942
Zebrafish AB Danio rerio STS genomic, sequence tagged site. Danio
rerio 41,242 31-Jul-98 GB_STS: G39530 822 G39530 Z22942 Zebrafish
AB Danio rerio STS genomic, sequence tagged site. Danio rerio
41,242 31-Jul-98 GB_PR3: HSDJ991C6 128995 AL078599 Human DNA
sequence from clone 991C6 on chromosome 6q14.1-15, Homo sapiens
35,188 23-Nov-99 complete sequence. rxa01602 1653 GB_EST38:
AW033000 685 AW033000 EST276559 tomato callus, TAMU Lycopersicon
esculentum cDNA clone Lycopersicon esculentum 44,706 15-Sep-99
cLEC19N6, mRNA sequence. GB_PL2: SPAC3C7 35052 Z99568 S. pombe
chromosome I cosmid c3C7. Schizosaccharomyces 38,158 29-Nov-99
pombe GB_PL2: SPAC3C7 35052 Z99568 S. pombe chromosome I cosmid
c3C7. Schizosaccharomyces 37,888 28-Nov-99 pombe rxa01605 1638
GB_HTG3: AC008689 145122 AC008689 Homo sapiens chromosome 5 clone
CIT978SKB_61G23, *** SEQUENCING IN Homo sapiens 35,448 3-Aug-99
PROGRESS ***, 44 unordered pieces. GB_HTG3: AC008689 145122
AC008689 Homo sapiens chromosome 5 clone CIT978SKB_61G23, ***
SEQUENCING IN Homo sapiens 35,448 3-Aug-99 PROGRESS ***, 44
unordered pieces. GB_HTG3: AC009175 233932 AC009175 Homo sapiens
chromosome 5 clone RPCI-PAC_241C15, *** SEQUENCING IN Homo sapiens
37,423 3-Aug-99 PROGRESS ***, 94 unordered pieces. rxa01610 852
GB_BA1: ECU82664 139818 U82664 Escherichia coli minutes 9 to 11
genomic sequence. Escherichia coli 34,198 11-Jan-97 GB_BA1:
ECU82664 139818 U82664 Escherichia coli minutes 9 to 11 genomic
sequence. Escherichia coli 36,949 11-Jan-97 GB_BA1: D90845 19366
D90845 E. coli genomic DNA, Kohara clone #356(46.1-46.5 min.).
Escherichia coli 39,808 21-MAR-1997 rxa01611 480 GB_PR3: AC005581
39601 AC005581 Homo sapiens chromosome 19, cosmid R31237, complete
sequence. Homo sapiens 38,901 1-Sep-98 GB_EST35: AI809560 443
AI809560 wf30h09.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone
IMAGE: Homo sapiens 35,989 7-Jul-99 2357153 3', mRNA sequence.
GB_EST25: AI279953 416 AI279953 qh90b02.x1 Soares_NFL_T_GBC_S1 Homo
sapiens cDNA clone IMAGE: Homo sapiens 35,276 27-Jan-99 1854219 3',
mRNA sequence. rxa01612 rxa01618 507 GB_GSS14: AQ506815 616
AQ506815 RPCI-11-316B19.TV RPCI-11 Homo sapiens genomic clone
RPCI-11-316B19, Homo sapiens 41,901 29-Apr-99 genomic survey
sequence. GB_HTG2: AC007512 168140 AC007512 Homo sapiens clone
hRPK.96_A_1, *** SEQUENCING IN PROGRESS ***, Homo sapiens 39,549
07-MAY-1999 14 unordered pieces. GB_HTG2: AC007512 168140 AC007512
Homo sapiens clone hRPK.96_A_1, *** SEQUENCING IN PROGRESS ***,
Homo sapiens 39,549 07-MAY-1999 14 unordered pieces. rxa01619 1098
GB_BA1: ECOUW93 338534 U14003 Escherichia coli K-12 chromosomal
region from 92.8 to 00.1 minutes. Escherichia coli 39,459 17-Apr-96
GB_BA2: AE000497 10334 AE000497 Escherichia coli K-12 MG1655
section 387 of 400 of the complete genome. Escherichia coli 39,459
12-Nov-98 GB_BA1: ECOLEUX 2147 M96355 Escherichia coli leucine tRNA
gene and ORF1 gene, complete cds. Escherichia coli 41,434 26-Jul-95
rxa01622 726 GB_PR4: AC007664 162470 AC007664 Homo sapiens,
complete sequence. Homo sapiens 37,006 18-Sep-99 GB_PR4: AC002472
147100 AC002472 Homo sapiens Chromosome 22q11.2 PAC Clone p_n5 In
BCRL2-GGT Region, Homo sapiens 33,058 13-Sep-99 complete sequence.
GB_BA1: SYCSLRG 135638 D64005 Synechocystis sp. PCC6803 complete
genome, 24/27, 3002966-3138603. Synechocystis sp. 38,755 13-Feb-99
rxa01623 834 GB_HTG4: AC007422 156484 AC007422 Homo sapiens clone
hRPK.68_A_1, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,759
23-OCT-1999 3 unordered pieces. GB_HTG4: AC007422 156484 AC007422
Homo sapiens clone hRPK.68_A_1, *** SEQUENCING IN PROGRESS ***,
Homo sapiens 36,759 23-OCT-1999 3 unordered pieces. GB_HTG4:
AC007422 156484 AC007422 Homo sapiens clone hRPK.68_A_1, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 33,495 23-OCT-1999 3
unordered pieces. rxa01624 468 GB_BA2: AE001816 10007 AE001816
Thermotoga maritima section 128 of 136 of the complete genome.
Thermotoga maritima 38,852 2-Jun-99 GB_RO: CCPH20 2152 X56332 Cavia
cobaya mRNA for PH-20 protein. Cavia porcellus 38,293 20-Feb-91
GB_PAT: I89388 2152 I89388 Sequence 1 from patent U.S. Pat. No.
5721348. Unknown. 38,293 10-Aug-98 rxa01628 1137 GB_BA1: CGPROPGEN
2936 Y12537 C. glutamicum proP gene. Corynebacterium 37,882
17-Nov-98 glutamicum GB_IN1: CET06E6 33238 Z81117 Caenorhabditis
elegans cosmid T06E6, complete sequence. Caenorhabditis elegans
38,33 2-Sep-99 GB_HTG2: AC006916 157093 AC006916 Caenorhabditis
elegans clone Y9C9, *** SEQUENCING IN PROGRESS ***, Caenorhabditis
elegans 36,519 24-Feb-99 3 unordered pieces. rxa01630 1200 GB_PR3:
AC004945 167372 AC004945 Homo sapiens PAC clone DJ0997N05 from
7q11.23-q21.1, complete sequence. Homo sapiens 34,996 26-Sep-98
GB_PR4: AC006385 173508 AC006385 Homo sapiens clone NH0559J05,
complete sequence. Homo sapiens 32,525 05-MAY-1999 GB_PR3: AC004945
167372 AC004945 Homo sapiens PAC clone DJ0997N05 from
7q11.23-q21.1, complete sequence. Homo sapiens 37,972 26-Sep-98
rxa01634 675 GB_PR4: AC005901 156763 AC005901 Homo sapiens
chromosome 17, clone hRPK.15_K_2, complete sequence. Homo sapiens
35,736 20-Jan-99 GB_PR4: AC005901 156763 AC005901 Homo sapiens
chromosome 17, clone hRPK.15_K_2, complete sequence. Homo sapiens
35,549 20-Jan-99 rxa01635 864 GB_HTG3: AC008590 268470 AC008590
Homo sapiens chromosome 5 clone CIT-HSPC_575D19, *** SEQUENCING IN
Homo sapiens 35,37 3-Aug-99 PROGRESS ***, 235 unordered pieces.
GB_HTG3: AC008590 268470 AC008590 Homo sapiens chromosome 5 clone
CIT-HSPC_575D19, *** SEQUENCING IN Homo sapiens 35,37 3-Aug-99
PROGRESS ***, 235 unordered pieces. GB_HTG3: AC008590 268470
AC008590 Homo sapiens chromosome 5 clone CIT-HSPC_575D19, ***
SEQUENCING IN Homo sapiens 38,571 3-Aug-99 PROGRESS ***, 235
unordered pieces. rxa01638 1023 GB_HTG3: AC008261 93735 AC008261
Arabidopsis thaliana chromosome III clone TAMU-T4P13, ***
SEQUENCING IN Arabidopsis thaliana 37,2 10-Aug-99 PROGRESS ***, 1
ordered pieces. GB_HTG3: AC008261 93735 AC008261 Arabidopsis
thaliana chromosome III clone TAMU-T4P13, *** SEQUENCING IN
Arabidopsis thaliana 37,2 10-Aug-99 PROGRESS ***, 1 ordered pieces.
GB_HTG3: AC008261 93735 AC008261 Arabidopsis thaliana chromosome
III clone TAMU-T4P13, *** SEQUENCING IN Arabidopsis thaliana 32,637
10-Aug-99 PROGRESS ***, 1 ordered pieces. rxa01641 1494 GB_PR3:
HS681N20 130263 AL031670 Human DNA sequence from clone 681N20 on
chromosome 20p12.1-13 Contains Homo sapiens 34,676 23-Nov-99
FTLL1(ferritin, light polypeptide-like 1), a gene similar to Zinc
finger, C3HC4 type (RING finger), weakly similar to SW: GOLI_DROME
Q06003 GOLIATH PROTEIN, ESTs, STS, GSS, CA repeat (D20S889), CpG
Islands, complete sequence. GB_HTG4: AC011177 168660 AC011177 Homo
sapiens clone 11_L_8, *** SEQUENCING IN PROGRESS ***, Homo sapiens
36,234 29-OCT-1999 7 unordered pieces. GB_HTG4: AC011177 168660
AC011177 Homo sapiens clone 11_L_8, *** SEQUENCING IN PROGRESS ***,
Homo sapiens 36,234 29-OCT-1999 7 unordered pieces. rxa01642 1365
GB_BA1: MTY15F10 38204 Z94121 Mycobacterium tuberculosis H37Rv
complete genome; segment 161/162. Mycobacterium 37,723 17-Jun-98
tuberculosis GB_BA1: SC3C3 31382 AL031231 Streptomyces coelicolor
cosmid 3C3. Streptomyces coelicolor 39,602 10-Aug-98 GB_BA1:
SCU33176 1238 U33176 Streptomyces coelicolor serine protease
gene, complete cds. Streptomyces coelicolor 41,467 9-Jan-96
rxa01643 549 GB_IN1: CEZC101 26147 Z93395 Caenorhabditis elegans
cosmid ZC101, complete sequence. Caenorhabditis elegans 36,28
23-Jul-99 GB_EST16: C47058 360 C47058 C47058 Yuji Kohara
unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis
elegans 39,944 18-OCT-1999 Caenorhabditis elegans cDNA clone
yk432e11 5', mRNA sequence. GB_HTG1: CEY54E2_1 110000 Z92861
Caenorhabditis elegans chromosome II clone Y54E2, *** SEQUENCING IN
Caenorhabditis elegans 36,28 29-Jul-98 PROGRESS ***, in unordered
pieces. rxa01645 729 GB_BA1: MTV025 121125 AL022121 Mycobacterium
tuberculosis H37Rv complete genome; segment 155/162. Mycobacterium
60,31 24-Jun-99 tuberculosis GB_BA1: MLCB2407 35615 AL023596
Mycobacterium leprae cosmid B2407. Mycobacterium leprae 37,378
27-Aug-99 GB BA1: MSGB577COS 37770 L01263 M. leprae genomic dna
sequence, cosmid b577. Mycobacterium leprae 57,829 14-Jun-96
rxa01646 942 GB BA1: MSGB577COS 37770 L01263 M. leprae genomic dna
sequence, cosmid b577. Mycobacterium leprae 53,781 14-Jun-96
GB_BA1: MLCB2407 35615 AL023596 Mycobacterium leprae cosmid B2407.
Mycobacterium leprae 39,348 27-Aug-99 GB_BA1: MTV025 121125
AL022121 Mycobacterium tuberculosis H37Rv complete genome; segment
155/162. Mycobacterium 53,503 24-Jun-99 tuberculosis rxa01647 1293
GB_GSS1: CNS010VB 837 AL099473 Drosophila melanogaster genome
survey sequence T7 end of BAC BACN05B20 Droasophila melanogaster
39,412 26-Jul-99 of DrosBAC library from Drosophila melanogaster
(fruit fly), genomic survey sequence. GB_EST1: T55021 429 T55021
yb42e09.r1 Stratagene fetal spleen (#937205) Homo sapiens cDNA
clone IMAGE: Homo sapiens 39,73 6-Feb-95 73864 5', mRNA sequence.
GB_EST38: AL120803 505 AL120803 DKFZp762E202_r1 762 (synonym:
hmel2) Homo sapiens cDNA clone Homo sapiens 40,476 27-Sep-99
DKFZp762E202 5', mRNA sequence. rxa01656 1020 GB_BA1: MTCY1A10
25949 Z95387 Mycobacterium tuberculosis H37Rv complete genome;
segment 117/162. Mycobacterium 37,771 17-Jun-98 tuberculosis
GB_BA1: MLCL581 36225 Z96801 Mycobacterium leprae cosmid L581.
Mycobacterium leprae 40,041 24-Jun-97 GB_PL2: ATAC003028 106448
AC003028 Arabidopsis thaliana chromosome II BAC F16M14 genomic
sequence, Arabidopsis thaliana 57,692 22-Jul-98 complete sequence.
rxa01658 1856 GB_BA1: MTV014 58280 AL021646 Mycobacterium
tuberculosis H37Rv complete genome; segment 137/162. Mycobacterium
38,877 18-Jun-98 tuberculosis GB_BA1: MTV030 29256 AL021428
Mycobacterium tuberculosis H37Rv complete genome; segment 4/162.
Mycobacterium 57,048 17-Jun-98 tuberculosis GB_BA1: MTV014 58280
AL021646 Mycobacterium tuberculosis H37Rv complete genome; segment
137/162. Mycobacterium 40,511 18-Jun-98 tuberculosis rxa01659 669
GB_HTG3: AC008604 136016 AC008604 Homo sapiens chromosome 5 clone
CIT978SKB_109F8, *** SEQUENCING Homo sapiens 35,106 3-Aug-99 IN
PROGRESS ***, 79 unordered pieces. GB_HTG3: AC008604 136016
AC008604 Homo sapiens chromosome 5 clone CIT978SKB_109F8, ***
SEQUENCING Homo sapiens 35,106 3-Aug-99 IN PROGRESS ***, 79
unordered pieces. GB_HTG3: AC011403 124903 AC011403 Homo sapiens
chromosome 5 clone CIT978SKB_3P13, *** SEQUENCING IN Homo sapiens
33,997 06-OCT-1999 PROGRESS ***, 7 ordered pieces. rxa01663 981
GB_HTG2: AC006799 278007 AC006799 Caenorhabditis elegans clone
Y51H7, *** SEQUENCING IN PROGRESS ***, Caenorhabditis elegans
34,787 23-Feb-99 7 unordered pieces. GB_HTG2: AC006799 278007
AC006799 Caenorhabditis elegans clone Y51H7, *** SEQUENCING IN
PROGRESS ***, Caenorhabditis elegans 34,787 23-Feb-99 7 unordered
pieces. GB_HTG2: AC006799 278007 AC006799 Caenorhabditis elegans
clone Y51H7, *** SEQUENCING IN PROGRESS ***, Caenorhabditis elegans
39,148 23-Feb-99 7 unordered pieces. rxa01665 843 GB_BA1: CGU43535
2531 U43535 Corynebacterium glutamicum multidrug resistance protein
(cmr) gene, complete cds. Corynebacterium 37,353 9-Apr-97
glutamicum GB_IN2: AF062971 359 AF062971 Anoplodactylus portus 28S
ribosomal RNA gene, partial sequence. Anoplodactylus portus 42,462
20-Apr-99 GB_EST31: AU062109 544 AU062109 AU062109 Dictyostelium
discoideum SL (H. Urushihara) Dictyostelium discoideum
Dictyostelium discoideum 34,81 20-MAY-1999 cDNA clone SLH629, mRNA
sequence. rxa01669 1038 GB_BA2: CGU89648 1105 U89648
Corynebacterium glutamicum unidentified sequence involved in
histidine Corynebacterium 65,152 30-MAR-1999 biosynthesis, partial
sequence. glutamicum GB_IN1: DMC86E4 29352 AL021086 Drosophila
melanogaster cosmid clone 86E4. Drosophila melanogaster 39,289
27-Apr-99 GB_PL1: ENY13759 3141 Y13759 Emericella nidulans abfB
gene. Emericella nidulans 38,552 05-MAR-1999 rxa01671 1272 GB_PH:
MPU46938 15664 U46938 Mycobacterium phage DS6A, Spe1/Nhel G
fragment sequence. Mycobacterium phage 60,751 29-Jun-96 DS6A
GB_PAT: I31047 15664 I31047 Sequence 3 from patent U.S. Pat. No.
5582969. Unknown. 60,751 6-Feb-97 GB_PAT: I36863 15664 I36863
Sequence 3 from patent U.S. Pat. No. 5612182. Unknown. 60,751
13-MAY-1997 rxa01672 465 GB_GSS14: AQ512046 462 AQ512046
HS_5113_B1_B10_SP6E RPCI-11 Human Male BAC Library Homo sapiens
Homo sapiens 40,882 05-MAY-1999 genomic clone Plate = 689 Col = 19
Row = D, genomic survey sequence. GB_GSS13: AQ475012 253 AQ475012
CITBI-E1-2592A3.TR CITBI-E1 Homo sapiens genomic clone 2592A3,
genomic Homo sapiens 35,417 23-Apr-99 survey sequence. GB_GSS14:
AQ512046 462 AQ512046 HS_5113_B1_B10_SP6E RPCI-11 Human Male BAC
Library Homo sapiens Homo sapiens 35,106 05-MAY-1999 genomic clone
Plate = 689 Col = 19 Row = D, genomic survey sequence. rxa01673
1158 GB_HTG5: AC010988 176452 AC010988 Homo sapiens clone
NH0570F04, WORKING DRAFT SEQUENCE, Homo sapiens 37,489 11-Nov-99 1
unordered pieces. GB_HTG5: AC010988 176452 AC010988 Homo sapiens
clone NH0570F04, WORKING DRAFT SEQUENCE, Homo sapiens 35,492
11-Nov-99 1 unordered pieces. rxa01675 534 GB_EST19: AA797620 497
AA797620 vw26b03.r1 Soares mouse mammary gland NbMMG Mus musculus
cDNA clone Mus musculus 44,318 10-Feb-98 IMAGE: 1244909 5', mRNA
sequence. GB_IN2: AF076597 846 AF076597 Dictyostelium discoideum
ublquitin-conjugating enzyme protein UbcC (ubcC) mRNA,
Dictyostelium discoideum 37,149 30-Jul-98 complete cds. GB_EST22:
C94466 698 C94466 C94466 Dictyostelium discoideum SS (H.
Urushihara) Dictyostelium discoideum Dictyostelium discoideum
33,647 15-Jun-98 cDNA clone SSL136, mRNA sequence. rxa01676 879
GB_IN1: CELR03H10 35080 U29382 Caenorhabditis elegans cosmid
R03H10. Caenorhabditis elegans 40,951 22-Jun-95 GB_EST37: AI998397
584 AI998397 701545552 A. thaliana, Columbia Col-0, rosette-2
Arabidopsis thaliana cDNA clone Arabidopsis thaliana 37,333
8-Sep-99 701545552, mRNA sequence. GB_GSS14: AQ551731 577 AQ551731
RPCI-11-383J4.TJ RPCI-11 Homo sapiens genomic clone RPCI-11-383J4,
genomic Homo sapiens 39,321 28-MAY-1999 survey sequence. rxa01677
867 GB_PL2: ATF6I18 122322 AL022198 Arabidopsis thaliana DNA
chromosome 4, BAC clone F6I18 (ESSA project). Arabidopsis thaliana
34,335 27-Aug-99 GB_PL2: ATF6I18 122322 AL022198 Arabidopsis
thaliana DNA chromosome 4, BAC clone F6I18 (ESSA project).
Arabidopsis thaliana 34,895 27-Aug-99 GB_OV: XLSDK2 2306 Y10350 X.
laevis mRNA for nuclear protein SDK2. Xenopus laevis 36,538
2-Apr-98 rxa01681 756 GB_HTG3: AC010798 172575 AC010798 Homo
sapiens chromosome 18 clone 470_B_24 map 18, *** SEQUENCING IN Homo
sapiens 37,116 23-Sep-99 PROGRESS ***, 7 unordered pieces. GB_HTG3:
AC010798 172575 AC010798 Homo sapiens chromosome 18 clone 470_B_24
map 18, *** SEQUENCING IN Homo sapiens 37,116 23-Sep-99 PROGRESS
***, 7 unordered pieces. GB_PL2: AF085231 3158 AF085231 Arabidopsis
thaliana phytochelatin synthase 1 (AtPCS1) gene, complete cds.
Arabidopsis thaliana 42,149 3-Jun-99 rxa01685 702 GB_HTG1: CEY48A6
296699 Z92854 Caenorhabditis elegans chromosome III clone Y48A6,
*** SEQUENCING IN Caenorhabditis elegans 37,393 31-Jul-98 PROGRESS
***, in unordered pieces. GB_HTG1: CEY48A6 296699 Z92854
Caenorhabditis elegans chromosome III clone Y48A6, *** SEQUENCING
IN Caenorhabditis elegans 37,393 31-Jul-98 PROGRESS ***, in
unordered pieces. GB_HTG1: CEY48A6 296699 Z92854 Caenorhabditis
elegans chromosome III clone Y48A6, *** SEQUENCING IN
Caenorhabditis elegans 32,946 31-Jul-98 PROGRESS ***, in unordered
pieces. rxa01686 564 GB_EST35: AV156415 240 AV156415 AV156415 Mus
musculus head C57BL/6J 12-day embryo Mus musculus cDNA clone Mus
musculus 40,417 7-Jul-99 3000002G04, mRNA sequence. GB_GSS15:
AQ611518 597 AQ611518 HS_5084_B2_H01_T7A RPCI-11 Human Male BAC
Library Homo sapiens Homo sapiens 41,848 15-Jun-99 genomic clone
Plate = 660 Col = 2 Row = P, genomic survey sequence. GB_BA1:
PDIORAB 5467 Z48918 P. diminuta iorA and iorB genes for
isoquinoline 1-oxidoreductase. Brevundimonas diminuta 36,709
15-Aug-95 rxa01693 1545 GB_IN1: CEF46B6 36616 Z70780 Caenorhabditis
elegans cosmid F46B6, complete sequence. Caenorhabditis elegans
36,856 04-DEC-1998 GB_EST5: L44364 362 L44364 HUMEST1G5 Human
thymus NSTH II Homo sapiens cDNA, mRNA sequence. Homo sapiens
38,136 17-Jan-96 GB_PR2: AF009282 414 AF009282 Homo sapiens clone
FBF3 Cri-du-chat region mRNA. Homo sapiens 46,809 17-Aug-97
rxa01694 1023 GB_BA1: CGA224946 2408 AJ224946 Corynebacterium
glutamicum DNA for L-Malate: quinone oxidoreductase.
Corynebacterium 100 11-Aug-98 glutamicum GB_EST7: W22650 715 W22650
71B2 Human retina cDNA Tsp509I-cleaved sublibrary Homo sapiens cDNA
not Homo sapiens 37,538 06-MAY-1996 directional, mRNA sequence.
GB_PR4: AC005343 137213 AC005343 Homo sapiens Chromosome 12p13.3
BAC RPCI11-21K20 (Roswell Park Cancer Homo sapiens 38,048 2-Apr-99
Institute Human BAC Library) complete sequence. rxa01696 1302
GB_BA1: MSGB1529CS 36985 L78824 Mycobacterium leprae cosmid B1529
DNA sequence. Mycobacterium leprae 67,442 15-Jun-96 GB_BA1: SC6A5
43632 AL049485 Streptomyces coelicolor cosmid 6A5. Streptomyces
coelicolor 66,821 24-MAR-1999 GB_BA1: MTV003 13246 AL008883
Mycobacterium tuberculosis H37Rv complete genome; segment 125/162.
Mycobacterium 38,802 17-Jun-98 tuberculosis rxa01697 1080 GB_PL2:
HNNHAHR 2559 L76588 Helianthus annuus homeodomain protein 1 mRNA,
complete cds. Helianthus annuus 38,257 02-OCT-1997 GB_PL2: HNNHAHR
2559 L76588 Helianthus annuus homeodomain protein 1 mRNA, complete
cds. Helianthus annuus 37,196 02-OCT-1997 rxa01701 472 GB_BA2:
AF069748 2103 AF069748 Pseudomonas chlororaphis polyurethanase
esterase A (pueA) gene, complete cds. Pseudomonas chlororaphis
39,13 4-Apr-99 GB_BA2: AF069748 2103 AF069748 Pseudomonas
chlororaphis polyurethanase esterase A (pueA) gene, complete cds.
Pseudomonas chlororaphis 40,271 4-Apr-99 rxa01703 1236 GB_BA1:
CGFDA 3371 X17313 Corynebacterium glutamicum fda gene for
fructose-bisphosphate aldolase Corynebacterium 100 12-Sep-93 (EC
4.1.2.13). glutamicum GB_EST18: AA728419 340 AA728419 33598 CD4-6
Arabidopsis thaliana cDNA clone K2C9RP, mRNA sequence. Arabidopsis
thaliana 36,176 5-Jan-98 GB_PL2: ATU90439 93639 U90439 Arabidopsis
thaliana chromosome II BAC T06D20 genomic sequence, Arabidopsis
thaliana 35,381 21-Jul-97 complete sequence. rxa01709 555 GB_OV:
AF033670 2353 AF033670 Gallus gallus T-Box protein 4 (TBX4) mRNA,
Gallus gallus 37,917 9-Jun-98 complete cds. GB_EST5: H85635 533
H85635 ys88c04.r1 Soares retina N2b5HR Homo sapiens cDNA clone
IMAGE: 221862 5', Homo sapiens 36,735 14-Nov-95 mRNA sequence.
GB_EST35: AI829867 427 AI829867 wj58c05.x1 NCI_CGAP_Lu19 Homo
sapiens cDNA clone IMAGE: 2407016 3', Homo sapiens 40,299 26-Aug-99
mRNA sequence. rxa01711 1281 GB_GSS10: AQ217798 441 AQ217798
HS_2007_A1_A04_MR CIT Approved Human Genomic Sperm Library D Homo
Homo sapiens 38,292 19-Sep-98 sapiens genomic clone Plate = 2007
Col = 7 Row = A, genomic survey sequence. GB_PAT: E05055 2053
E05055 DNA encoding D-threonine aldolase(DTA). Xanthomonas oryzae
36,475 29-Sep-97 GB_PR3: HSJ570L12 143508 AL049589 Human DNA
sequence from clone 570L12 on chromosome Xq13.1-21.1. Contains the
Homo sapiens 36,262 23-Nov-99 PGK1 gene for phosphoglycerate kinase
1, the gene for a novel protein similar to TAF2G (TATA box binding
protein (TBP)-associated factor, RNA polymerase II, G, 32 kD)
(TAFII31)), ESTs, STS, GSSs and a putative CpG island, complete
sequence. rxa01714 rxa01715 819 GB_BA1: MTCY441 35187 Z80225
Mycobacterium tuberculosis H37Rv complete genome; segment 118/162.
Mycobacterium 36,216 18-Jun-98 tuberculosis GB_BA1: SC1B5 14866
AL023517 Streptomyces coelicolor cosmid 1B5. Streptomyces
coelicolor 56,807 11-MAY-1998 GB_BA1: MSGB1912CS 38503 L01536 M.
leprae genomic dna sequence, cosmid b1912. Mycobacterium leprae
55,651 14-Jun-96 rxa01729 642 GB_BA2: CORCSLYS 2821 M89931
Corynebacterium glutamicum beta C-S lyase (aecD) and branched-chain
amino acid Corynebacterium 41,993 4-Jun-98 uptake carrier (brnQ)
genes, complete cds, and hypothetical protein Yhbw glutamicum
(yhbw) gene, partial cds. GB_HTG4: AC010037 166249 AC010037
Drosophila melanogaster chromosome 3L/66B6 clone RPCI98-6E4,
Drosophila melanogaster 34,951 16-OCT-1999 *** SEQUENCING IN
PROGRESS ***, 52 unordered pieces.
GB_HTG4: AC010037 166249 AC010037 Drosophila melanogaster
chromosome 3L/66B6 clone RPCI98-6E4, Drosophila melanogaster 34,951
16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 52 unordered pieces.
rxa01731 822 GB_GSS3: B83621 616 B83621 RPCI11-16H17.TPB RPCI-11
Homo sapiens genomic clone RPCI-11-16H17, Homo sapiens 40,899
9-Apr-99 genomic survey sequence. GB_GSS3: B82563 586 B82563
RPCI11-16N17.TP RPCI-11 Homo sapiens genomic clone RPCI-11-16N17,
Homo sapiens 40,235 9-Apr-99 genomic survey sequence. GB_HTG3:
AC009074 45999 AC009074 Homo sapiens chromosome 16 clone
RPCI-11_323C21, *** SEQUENCING IN Homo sapiens 36,783 3-Aug-99
PROGRESS ***, 27 unordered pieces. rxa01734 657 GB_GSS14: AQ545618
327 AQ545618 CITBI-E1-2636O13.TR CITBI-E1 Homo sapiens genomic
clone 2636O13, Homo sapiens 38,154 28-MAY-1999 genomic survey
sequence. GB_HTG2: AC006629 27659 AC006629 Caenorhabditis elegans
clone F12E12, *** SEQUENCING IN PROGRESS***, Caenorhabditis elegans
35,658 23-Feb-99 1 unordered pieces. GB_HTG2: AC006629 27659
AC006629 Caenorhabditis elegans clone F12E12, *** SEQUENCING IN
PROGRESS ***, Caenorhabditis elegans 35,714 23-Feb-99 1 unordered
pieces. rxa01738 837 GB_HTG1: CNS01DSB 222193 AL121768 Homo sapiens
chromosome 14 clone R-976B16, *** SEQUENCING IN Homo sapiens 36,978
05-OCT-1999 PROGRESS ***, in ordered pieces. GB_HTG1: CNS01DSB
222193 AL121768 Homo sapiens chromosome 14 clone R-976B16, ***
SEQUENCING IN Homo sapiens 36,978 05-OCT-1999 PROGRESS ***, in
ordered pieces. GB_HTG5: AC011170 171788 AC011170 Homo sapiens
clone 10_L_13, *** SEQUENCING IN Homo sapiens 35,259 5-Nov-99
PROGRESS ***, 14 unordered pieces. rxa01741 921 GB_IN1: CEK04G11
34190 Z78544 Caenorhabditis elegans cosmid K04G11, complete
sequence. Caenorhabditis elegans 35,055 6-Sep-99 GB_HTG2: AC005995
170023 AC005995 Homo sapiens clone DJ0042M02, *** SEQUENCING IN
Homo sapiens 33,624 23-Apr-99 PROGRESS ***, 13 unordered pieces.
GB_HTG2: AC005995 170023 AC005995 Homo sapiens clone DJ0042M02, ***
SEQUENCING IN Homo sapiens 33,624 23-Apr-99 PROGRESS ***, 13
unordered pieces. rxa01742 627 GB_EST30: AI658116 497 AI658116
fc22e07.y1 Zebrafish WashU MPIMG EST Danio rerio cDNA 5' similar to
TR: Danio rerio 35,604 06-MAY-1999 Q15883 Q15883 X104.;, mRNA
sequence. GB_HTG1: CEY60A9 275370 AL022281 Caenorhabditis elegans
chromosome X clone Y60A9, *** SEQUENCING IN Caenorhabditis elegans
35,61 2-Sep-99 PROGRESS ***, in unordered pieces. GB_HTG1: CEY60A9
275370 AL022281 Caenorhabditis elegans chromosome X clone Y60A9,
*** SEQUENCING IN Caenorhabditis elegans 35,61 2-Sep-99 PROGRESS
***, in unordered pieces. rxa01748 903 GB_GSS13: AQ447364 439
AQ447364 mgxb0006N01r CUGI Rice Blast BAC Library Magnaporthe
grisea genomic Magnaporthe grisea 34,889 8-Apr-99 clone
mgxb0006N01r, genomic survey sequence. GB_PR2: HSJ247G22 120487
AL096866 Human DNA sequence from clone RP1-247G22 on chromosome
6p12.2-21.2, Homo sapiens 39,31 22-Nov-99 complete sequence.
GB_GSS5: AQ811603 375 AQ811603 HS_5460_B1_C09_SP6E RPCI-11 Human
Male BAC Library Homo sapiens Homo sapiens 38,133 25-Aug-99 genomic
clone Plate = 1036 Col = 17 Row = F, genomic survey sequence.
rxa01749 1740 GB_HTG5: AC009544 211057 AC009544 Homo sapiens
chromosome 11 clone RP11-85D24 map 11, WORKING Homo sapiens 37,433
19-Nov-99 DRAFT SEQUENCE, 14 unordered pieces. GB_HTG5: AC009544
211057 AC009544 Homo sapiens chromosome 11 clone RP11-85D24 map 11,
WORKING Homo sapiens 37,069 19-Nov-99 DRAFT SEQUENCE, 14 unordered
pieces. rxa01750 rxa01752 1584 GB_PR1: HUMPROFILX 17630 M96943
Human profilaggrin gene exons 1-3, 5' end. Homo sapiens 36,352
27-Apr-93 GB_PL2: AF049174 535 AF049174 Tolypocladium inflatum NRRL
28024 28S ribosomal RNA gene, partial sequence. Tolypocladium
inflatum 40,187 03-MAR-1999 GB_BA1: MLCL458 43839 AL049478
Mycobacterium leprae cosmid L458. Mycobacterium leprae 40,322
27-Aug-99 rxa01753 1662 GB_PR1: HUMPROFILX 17630 M96943 Human
profilaggrin gene exons 1-3, 5' end. Homo sapiens 36,794 27-Apr-93
GB_PL1: YSCFBPA 2202 J03207 S. cerevisiae
fructose-1,6-bisphosphatase (FBP) gene, complete cds. Saccharomyces
cerevisiae 37,762 27-Apr-93 GB_PL2: YSCL8039 31806 U19103
Saccharomyces cerevisiae chromosome XII cosmid 8039. Saccharomyces
cerevisiae 37,685 22-Aug-97 rxa01754 rxa01760 405 GB_IN1: CELF43C9
34037 U40427 Caenorhabditis elegans cosmid F43C9. Caenorhabditis
elegans 40,945 16-Nov-95 GB_IN1: CELF43C9 34037 U40427
Caenorhabditis elegans cosmid F43C9. Caenorhabditis elegans 35,484
16-Nov-95 GB_RO: MUSOP5F 3405 D14816 Mouse osteopontin gene, 5'
flanking region. Mus musculus 35,264 4-Feb-99 rxa01761 4587 GB_PR4:
AC004600 133863 AC004600 Homo sapiens Chromosome 15q11-q13 PAC
clone pDJ373b1 containing Homo sapiens 37,037 11-MAR-1999 Angelman
Syndrome gene (UBE3A), complete sequence. GB_PR3: AC004259 118684
AC004259 Human Chromosome 15q11-q13 PAC clone pDJ14i12 containing
Angelman Homo sapiens 37,037 3-Jun-98 Syndrome gene (UBE3A),
complete sequence. GB_PR4: AC004600 133863 AC004600 Homo sapiens
Chromosome 15q11-q13 PAC clone pDJ373b1 containing Homo sapiens
35,995 11-MAR-1999 Angelman Syndrome gene (UBE3A), complete
sequence. rxa01765 1065 GB_EST31: AI694883 370 AI694883 we52h02.x1
NCI_CGAP_Co3 Homo sapiens cDNA clone IMAGE: 2344755 Homo sapiens
39,566 3-Jun-99 3', mRNA sequence. GB_EST6: W08057 341 W08057
mb37e05.r1 Soares mouse p3NMF19.5 Mus musculus cDNA clone IMAGE:
331616 Mus musculus 37,353 5-Sep-96 5' similar to gb: Z23090 HEAT
SHOCK 27 KD PROTEIN (HUMAN); gb: L11609 Mus musculus heat shock
protein 25 (MOUSE);, mRNA sequence. GB_IN1: CELC39D10 40897 U39678
Caenorhabditis elegans cosmid C39D10. Caenorhabditis elegans 39,59
2-Nov-95 rxa01767 588 GB_IN1: CEF16H9 21721 Z50005 Caenorhabditis
elegans cosmid F16H9, complete sequence. Caenorhabditis elegans
36,667 2-Sep-99 GB_IN1: CECC4 32063 Z81490 Caenorhabditis elegans
cosmid CC4, complete sequence. Caenorhabditis elegans 35,094
2-Sep-99 GB_HTG1: CEY26D4 156152 AL022595 Caenorhabditis elegans
chromosome I clone Y2604, *** SEQUENCING IN Caenorhabditis elegans
33,276 7-Sep-99 PROGRESS ***, in unordered pieces. rxa01768
rxa01769 564 GB_HTG4: AC010034 130818 AC010034 Drosophila
melanogaster clone RPCI98-4O3,*** SEQUENCING IN Drosophila
melanogaster 35,74 16-OCT-1999 PROGRESS ***, 63 unordered pieces.
GB_HTG4: AC010034 130818 AC010034 Drosophila melanogaster clone
RPCI98-4O3, *** SEQUENCING IN Drosophila melanogaster 35,74
16-OCT-1999 PROGRESS ***, 63 unordered pieces. GB_EST1: D36647 360
D36647 CELK035EZF Yuji Kohara unpublished cDNA Caenorhabditis
elegans cDNA clone Caenorhabditis elegans 37,87 8-Aug-94 yk35e12
5', mRNA sequence. rxa01770 3888 GB_IN1: SUSENDO16C 4692 L34680
Strongylocentrotus purpuratus calcium-binding protein (endo16)
mRNA, Strongylocentrotus 39,337 21-Jul-94 complete cds. purpuratus
GB_EST31: AF121176 535 AF121176 AF121176 Homo sapiens liver (Chang
L-Y) Homo sapiens cDNA clone Homo sapiens 39,626 24-MAY-1999
PFTTA2-2, mRNA sequence. GB_PR1: AB011149 5134 AB011149 Homo
sapiens mRNA for KIAA0577 protein, complete cds. Homo sapiens
38,279 10-Apr-98 rxa01771 825 GB_BA1: CGPROPGEN 2936 Y12537 C.
glutamicum proP gene. Corynebacterium 100 17-Nov-98 glutamicum
GB_EST33: AI778471 545 AI778471 EST259350 tomato susceptible,
Cornell Lycopersicon esculentum cDNA clone Lycopersicon esculentum
41,187 29-Jun-99 cLES5M16, mRNA sequence. GB_IN1: CET11F9 37714
Z74042 Caenorhabditis elegans cosmid T11F9, complete sequence.
Caenorhabditis elegans 38,077 23-Nov-98 rxa01773 600 GB_HTG2:
U82212 46387 U82212 Homo sapiens chromosome 10 clone
LA10NC01_23_C_3 map 10q26.1-10q26.2, Homo sapiens 42,142
09-DEC-1998 *** SEQUENCING IN PROGRESS ***, 1 ordered pieces.
GB_HTG2: U82212 46387 U82212 Homo sapiens chromosome 10 clone
LA10NC01_23_C_3 map 10q26.1-10q26.2, Homo sapiens 42,142
09-DEC-1998 *** SEQUENCING IN PROGRESS ***, 1 ordered pieces.
GB_HTG2: U82212 46387 U82212 Homo sapiens chromosome 10 clone
LA10NC01_23_C_3 map 10q26.1-10q26.2, Homo sapiens 37,748
09-DEC-1998 *** SEQUENCING IN PROGRESS ***, 1 ordered pieces.
rxa01774 849 GB_HTG1: HSA557H15 228174 AL078590 Homo sapiens
chromosome 6 clone RP11-557H15, *** SEQUENCING IN Homo sapiens
38,054 23-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1:
HSA557H15 228174 AL078590 Homo sapiens chromosome 6 clone
RP11-557H15, *** SEQUENCING IN Homo sapiens 38,054 23-Nov-99
PROGRESS ***, in unordered pieces. GB_PL2: YSCH9998 35600 U00030
Saccharomyces cerevisiae chromosome VIII cosmid 9998. Saccharomyces
cerevisiae 39,11 2-Sep-97 rxa01775 687 GB_PR3: HS37J18 131427
Z98747 Human DNA sequence from clone 37J18 on chromosome
1p36.2-36.3. Contains a Homo sapiens 35,036 23-Nov-99 putative
novel gene. ESTs and GSSs, complete sequence. GB_HTG2: AC007475
185087 AC007475 Drosophila melanogaster chromosome 2 clone
BACR04E21 (D592) RPCI-98 04.E.21 Drosophila melanogaster 37,333
2-Aug-99 map 49A-49B strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 36 unordered pieces. GB_HTG2: AC007475 185087 AC007475
Drosophila melanogaster chromosome 2 clone BACR04E21 (D592) RPCI-98
04.E.21 Drosophila melanogaster 37,333 2-Aug-99 map 49A-49B strain
y; cn bw sp, *** SEQUENCING IN PROGRESS***, 36 unordered pieces.
rxa01776 1575 GB_GSS10: AQ174954 416 AQ174954 HS_3211_22_C03_MR CIT
Approved Human Genomic Sperm Library D Homo Homo sapiens 43,171
17-OCT-1998 sapiens genomic clone Plate = 3211 Col = 6 Row = F,
genomic survey sequence. GB_PR1: HSFGF6 1032 X57075 H. sapiens FGF6
gene. Homo sapiens 41,196 15-Feb-95 GB_PR2: HSAC000055 93578
AC000055 Human PAC clone DJ073F11 from Xq23, complete sequence.
Homo sapiens 35,08 14-Nov-96 rxa01777 582 GB_BA2: AF076997 15398
AF076997 Comamonas testosteroni PtL5 cryptic plasmid pPT1, complete
sequence. Comamonas testosteroni 37,805 30-Nov-99 GB_BA2: AF076997
15398 AF076997 Comamonas testosteroni PtL5 cryptic plasmid pPT1,
complete sequence. Comamonas testosteroni 35,529 30-Nov-99 rxa01778
1260 GB_PR3: AC002981 153568 AC002981 Homo sapiens Xp22 BAC
GS279A12 (Genome Systems) complete sequence. Homo sapiens 37,305
22-Jan-98 GB_EST29: AI587176 384 AI587176 tr54c10.x1 NCI_CGAP_Pan1
Homo sapiens cDNA clone IMAGE: 2222130 3', Homo sapiens 37,24
14-MAY-1999 mRNA sequence. GB_PR1: HSCP450 1346 X65962 H. sapiens
mRNA for cytochrome P-450. Homo sapiens 38,906 29-MAY-1992 rxa01779
1542 GB_EST19: AA202518 661 AA202518 LD02757.5prime LD Drosophila
melanogaster embryo BlueScript Drosophila Drosophila melanogaster
40,212 27-Nov-98 melanogaster cDNA clone LD02757 5prime, mRNA
sequence. GB_EST34: AI805834 453 AI805834 te52b03.x1
Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone IMAGE: Homo sapiens 38
7-Jul-99 2090285 3' similar to contains Alu repetitive element;,
mRNA sequence. GB_EST30: AI648920 754 AI648920 uk32h03.x1 Sugano
mouse kidney mkia Mus musculus cDNA clone IMAGE: Mus musculus
36,967 30-Apr-99 1970741 3' similar to WP: Y76A2B.5 CE19277;, mRNA
sequence. rxa01780 498 GB_GSS8: AQ038759 670 AQ038759
CIT-HSP-2325O13.TV CIT-HSP Homo sapiens genomic clone Homo sapiens
32,645 11-Jul-98 2325O13, genomic survey sequence. GB_GSS8:
AQ038759 670 AQ038759 CIT-HSP-2325O13.TV CIT-HSP Homo sapiens
genomic clone Homo sapiens 39,474 11-Jul-98 2325O13, genomic survey
sequence. rxa01781 384 GB_IN1: CELF52G3 42696 AF026212
Caenorhabditis elegans cosmid F52G3. Caenorhabditis elegans 39,314
25-Sep-97 GB_GSS14: AQ579313 877 AQ579313 nbxb0084O07r CUGI Rice
BAC Library Oryza sativa genomic clone Oryza sativa 36,053 2-Jun-99
nbxb0084O07r, genomic survey sequence. GB_VI: HAV19AE3 3441 X95259
Human adenovirus type 19a early region 3 genes. Human adenovirus
type 38,624 9-Jul-97 19a rxa01782 519 GB_IN1: DMSED5 930 X78219 D.
melanogaster (Barton) SED5 mRNA. Drosophila melanogaster 38,372
21-Apr-95 GB_IN2: L49408 83527 L49408 Drosophila melanogaster DNA
sequence (P1 DS02740 (D27)), complete sequence. Drosophila
melanogaster 35,992 17-Jul-98 GB_STS: G46002 398 G46002 Z556_1
Zebrafish AB Danio rerio STS genomic clone Z556 5', sequence tagged
site. Danio rerio 33,92 23-MAR-1999 rxa01783 360 GB_VI: CITV18420
19259 Y18420 Citrus tristeza virus complete genome, isolate T385.
Citrus tristeza virus 41,457 6-Apr-99 GB_IN1: DMSED5 930 X78219 D.
melanogaster (Barton) SED5 mRNA. Drosophila melanogaster 45,802
21-Apr-95 GB_VI: CTY18368 2759 Y18368 Citrus tristeza virus
defective RNA, strain T411. Citrus tristeza virus 41,457 6-Apr-99
rxa01785 699 GB_BA2: AF121000 19751 AF121000 Corynebacterium
glutamicum strain 22243 R-plasmid pAG1, complete sequence.
Corynebacterium 40,529 14-Apr-99 glutamicum GB_PR2: HS1014D13 71263
AL022311 Human DNA sequence from clone 1014D13 on chromosome
22q13.1-13.2 Homo sapiens 35,362 23-Nov-99 Contains ESTs, STSs, and
a CpG island, complete sequence. GB_BA2: AF121000 19751 AF121000
Corynebacterium glutamicum strain 22243 R-plasmid pAG1, complete
sequence. Corynebacterium 38,012 14-Apr-99 glutamicum rxa01787 816
GB_RO: RATSIALYLA 1128 L13445 Rat sialyltransferase gene family
related mRNA, complete cds. Rattus norvegicus 35,012 26-Jul-93
GB_PR3: HSN75H12 46144 Z84496 Human DNA sequence from cosmid N75H12
on chromosome 22q12-qter. Homo sapiens 37,738 23-Nov-99 GB_GSS13:
AQ496514 532 AQ496514 HS_5118_B2_F05_SP6E RPCI-11 Human Male BAC
Library Homo Homo sapiens 39,238 28-Apr-99 sapiens genomic clone
Plate = 694 Col = 10 Row = L, genomic survey sequence. rxa01788
rxa01789 765 GB_BA1: MTV029 3279 AL021427 Mycobacterium
tuberculosis H37Rv complete genome; segment 1/162. Mycobacterium
39,229 17-Jun-98 tuberculosis GB_BA1: MTORIREP 8400 X92504 M.
tuberculosis origin of replication and genes rnpA, rpmH, dnaA,
dnaN, recF. Mycobacterium 36,328 26-Aug-97 tuberculosis GB_GSS4:
AQ729452 763 AQ729452 HS_5474_A1_G07_T7AHS_5474_A1 RPCI-11 Human
Male BAC Library Homo Homo sapiens 39,451 15-Jul-99 sapiens genomic
clone Plate = 1050 Col = 13 Row = M, genomic survey sequence.
rxa01790 183 GB_EST37: AI935426 436 AI935426 wo84d02.x1
NCI_CGAP_Kid11 Homo sapiens cDNA clone IMAGE: 2462019 Homo sapiens
39,877 2-Sep-99 3' similar to TR: O00193 O00193 SMALL ACIDIC
PROTEIN.;, mRNA sequence. GB_GSS11: AQ265301 621 AQ265301
CITBI-E1-2509K16.TF CITBI-E1 Homo sapiens genomic clone 2509K16,
Homo sapiens 45,856 27-OCT-1998 genomic survey sequence. GB_HTG2:
AC007596 199300 AC007596 Homo sapiens chromosome 16 clone 116B6,
*** SEQUENCING Homo sapiens 37,572 20-MAY-1999 IN PROGRESS ***, 42
unordered pieces. rxa01791 486 GB_PL2: ATAC004521 104797 AC004521
Arabidopsis thaliana chromosome II BAC F4I1 genomic sequence,
complete Arabidopsis thaliana 43,167 12-MAY-1998 sequence.
GB_GSS13: AQ436125 508 AQ436125 HS_5049_B2_G12_T7A RPCI-11 Human
Male BAC Library Homo Homo sapiens 32,762 31-MAR-1999 sapiens
genomic clone Plate = 625 Col = 24 Row = N, genomic survey
sequence. GB_GSS12: AQ342410 674 AQ342410 RPCI11-121E5.TJ RPCI-11
Homo sapiens genomic clone RPCI-11-121E5, Homo sapiens 37,269
06-MAY-1999 genomic survey sequence. rxa01792 396 GB_STS: KLAJ9905
178 AJ229905 Kluyveromyces lactis DNA fragment for sequence tagged
site, clone okam5e06r. Kluyveromyces lactis 42,697 20-Nov-98
GB_STS: KLAJ9905 178 AJ229905 Kluyveromyces lactis DNA fragment for
sequence tagged site, clone okam5e06r. Kluyveromyces lactis 42,697
20-Nov-98 GB_GSS15: AQ612295 472 AQ612295 HS_5121_A2_D09_SP6E
RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 40,885
15-Jun-99 genomic clone Plate = 697 Col = 18 Row = G, genomic
survey sequence. rxa01793 357 GB_GSS3: B82515 613 B82515
RPCI11-16J10.TV RPCI-11 Homo sapiens genomic clone RPCI-11-16J10,
Homo sapiens 40,164 9-Apr-99 genomic survey sequence. GB_PR2:
CNS0000B 196287 AL049829 Human chromosome 14 DNA sequence *** IN
PROGRESS *** BAC R-124D2 Homo sapiens 33,621 27-OCT-1999 of RPCI-11
library from chromosome 14 of Homo sapiens (Human), complete
sequence. GB_OV: AF001393 4329 AF001393 Oryzias latipes Medaka
OG-12 (MOG-12) mRNA, complete cds. Oryzias latipes 35,511 30-Sep-99
rxa01794 357 GB_GSS15: AQ644157 665 AQ644157 RPCI93-Dpnll-29O12.TV
RPCI93-Dpnll Trypanosoma brucei genomic clone Trypanosoma brucei
39,894 8-Jul-99 RPCI93-Dpnll-29O12, genomic survey sequence.
GB_GSS15: AQ657704 665 AQ657704 Sheared DNA-24C24.TR Sheared DNA
Trypanosoma brucei genomic clone Trypanosoma brucei 37,11 23-Jun-99
Sheared DNA-24C24, genomic survey sequence. GB_OV: GGU25125 6418
U25125 Gallus gallus preprogastrin gene, complete cds. Gallus
gallus 40,584 06-MAY-1995 rxa01796 897 GB_PR3: HS404G5 119737
AL035695 Human DNA sequence from clone 404G5 on chromosome
6q24.1-25.2. Homo sapiens 34,793 23-Nov-99 Contains part of a human
estrogen receptor gene, STSs and GSSs, complete sequence. GB_PR1:
HSPTP1CHG 8545 X82818 H. sapiens PTP1C/HCP gene. Homo sapiens
35,531 26-Jun-97 GB_PR3: HS404G5 119737 AL035695 Human DNA sequence
from clone 404G5 on chromosome 6q24.1-25.2. Homo sapiens 37,058
23-Nov-99 Contains part of a human estrogen receptor gene, STSs and
GSSs, complete sequence. rxa01799 1317 GB_HTG3: AC010869 38000
AC010869 Leishmania major chromosome 35 clone L7195 strain
Friedlin, Leishmania major 40,522 02-OCT-1999 *** SEQUENCING IN
PROGRESS ***, 4 unordered pieces. GB_HTG3: AC010869 38000 AC010869
Leishmania major chromosome 35 clone L7195 strain Friedlin,
Leishmania major 40,522 02-OCT-1999 *** SEQUENCING IN PROGRESS ***,
4 unordered pieces. GB_OM: SSU12574 2190 U12574 Sus scrofa myogenic
regulatory factor MyoD (myoD) gene, complete cds. Sus scrofa 37,068
10-Feb-96 rxa01800 843 GB_PH: C2PVCG 22172 L48605 Bacteriophage c2
complete genome. Lactococcus bacteriophage 36,747 14-MAR-1996 c2
GB_EST38: AW066009 641 AW066009 687004F08.y1 687 - Early embryo
from Delaware Zea mays cDNA, mRNA sequence. Zea mays 40 12-OCT-1999
GB_PH: C2PVCG 22172 L48605 Bacteriophage c2 complete genome.
Lactococcus bacteriophage 36,867 14-MAR-1996 c2 rxa01803 1083
GB_BA2: SCJ1 36925 AL109962 Streptomyces coelicolor cosmid J1.
Streptomyces coelicolor 54,267 24-Sep-99 A3(2) GB_BA1: PAU12891
4062 U12891 Pseudomonas aeruginosa PAO substrain OT684 pyoverdine
gene transcriptional Pseudomonas aeruginosa 37,841 03-OCT-1996
regulator PvdS (pvdS) gene, complete cds. GB_HTG6: AC010203 230460
AC010203 Homo sapiens clone RP11-175P13, *** SEQUENCING Homo
sapiens 35,185 03-DEC-1999 IN PROGRESS ***, 48 unordered pieces.
rxa01804 444 GB_EST24: AI189912 784 AI189912 qd33e07.x1
Soares_placenta_8to9weeks_2NbHP8to9W Homo sapiens cDHA clone Homo
sapiens 40 28-OCT-1996 IMAGE: 1725540 3' similar to gb: Z23064_cds1
HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN G (HUMAN);, mRNA sequence.
GB_EST24: AI189912 784 AI189912 qd33e07.x1
Soares_placenta_8to9weeks_2NbNP8to9W Homo sapiens cDNA clone Homo
sapiens 35,294 28-OCT-1998 IMAGE: 1725540 3' similar to gb:
Z23064_cds1 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN G (HUMAN);,
mRNA sequence. rxa01805 453 GB_PR2: HSU73628 32289 U73628 Human
chromosome 11 101h11 cosmid, complete sequence. Homo sapiens 36,099
19-Jun-97 GB_PR2: HSU73628 32289 U73628 Human chromosome 11 101h11
cosmid, complete sequence. Homo sapiens 35,227 19-Jun-97 rxa01806
603 GB_IN1: CELK02E7 36535 AF025465 Caenorhabditis elegans cosmid
K02E7. Caenorhabditis elegans 37,479 23-Sep-97 GB_HTG3: AC011217
157261 AC011217 Homo sapiens clone 7_J_14, LOW-PASS SEQUENCE
SAMPLING. Homo sapiens 33,333 03-OCT-1999 GB_HTG3: AC011217 157261
AC011217 Homo sapiens clone 7_J_14, LOW-PASS SEQUENCE SAMPLING.
Homo sapiens 33,333 03-OCT-1999 rxa01809 1299 GB_HTG3: AC010759
155875 AC010759 Homo sapiens clone 1_K_15, *** SEQUENCING IN Homo
sapiens 37,92 22-Sep-99 PROGRESS ***, 15 unordered pieces. GB_HTG3:
AC010759 155875 AC010759 Homo sapiens clone 1_K_15, *** SEQUENCING
IN Homo sapiens 37,92 22-Sep-99 PROGRESS ***, 15 unordered pieces.
GB_HTG2: AC006235 190842 AC006235 Homo sapiens clone hRPK.520_J_4,
*** SEQUENCING IN Homo sapiens 36,019 17-Jul-99 PROGRESS ***, 5
unordered pieces. rxa01813 789 GB_PR4: AC004047 134649 AC004047
Homo sapiens chromosome 4 clone B150J4 map 4q25, complete sequence.
Homo sapiens 36,205 01-DEC-1998 GB_HTG2: HS1012F16 74539 AL080274
Homo sapiens chromosome 20 clone RP5-1012F16, *** SEQUENCING Homo
sapiens 35,032 03-DEC-1999 IN PROGRESS ***, in unordered pieces.
GB_HTG2: HS1012F16 74539 AL080274 Homo sapiens chromosome 20 clone
RP5-1012F16, *** SEQUENCING Homo sapiens 35,032 03-DEC-1999 IN
PROGRESS ***, in unordered pieces. rxa01815 915 GB_PR3: AC005740
186780 AC005740 Homo sapiens chromosome 5p, BAC clone 50g21 (LBNL
H154), complete sequence. Homo sapiens 37,315 01-OCT-1998 GB_HTG3:
AC008328 114617 AC008328 Drosophila melanogaster chromosome 2 clone
BACR09A04 (D860) Drosophila melanogaster 30,516 6-Aug-99 RPCI-98
09.A.4 map 28B-28C strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 74 unordered pieces. GB_HTG3: AC008328 114617 AC008328
Drosophila melanogaster chromosome 2 clone BACR09A04 (D860)
Drosophila melanogaster 30,516 6-Aug-99 RPCI-98 09.A.4 map 28B-28C
strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 74 unordered
pieces. rxa01816 855 GB_PR3: AC003101 208396 AC003101 Homo sapiens
chromosome 17, clone HRPC41C23, complete sequence. Homo sapiens
34,272 5-Jun-98 GB_EST23: AI144656 492 AI144656
UI-R-BT0-pl-f-04-0-UI.s1 UI-R-BT0 Rattus norvegicus cDNA clone
Rattus norvegicus 37,526 5-Jul-99 UI-R-BT0-pl-f-04-0-UI 3', mRNA
sequence. GB_GSS11: AQ341706 506 AQ341706 RPCI11-120J20.TJ RPCI-11
Homo sapiens genomic clone Homo sapiens 40,789 06-MAY-1999
RPCI-11-120J20, genomic survey sequence. rxa01817 756 GB_BA2:
AF030176 7000 AF030176 Rhodococcus opacus putative transposase
gene, partial cds; and Rhodococcus opacus 42,577 5-Aug-98 putative
FAD synthetase, putative short-chain dehydrogenase/reductase,
maleylacetate reductase (macA), and putative transcription factor
genes, complete cds. GB_EST19: AA263350 423 AA263350 LD06495.5prime
LD Drosophila melanogaster embryo BlueScript Drosophila Drosophila
melanogaster 38,955 27-Nov-98 melanogaster cDNA clone LD06495
5prime, mRNA sequence. GB_EST19: AA202194 368 AA202194
LD02304.5prime LD Drosophila melanogaster embryo BlueScript
Drosophila Drosophila melanogaster 39,891 27-Nov-98 melanogaster
cDNA clone LD02304 5prime, mRNA sequence. rxa01820 1497 GB_BA2:
AF030176 7000 AF030176 Rhodococcus opacus putative transposase
gene, partial cds; and putative Rhodococcus opacus 41,799 5-Aug-98
FAD synthetase, putative short-chain dehydrogenase/reductase,
maleylacetate reductase (macA), and putative transcription factor
genes, complete cds. GB_EST32: AI728582 666 AI728582 BNLGHi11124
Six-day Cotton fiber Gossypium hirsutum cDNA 5' Gossypium hirsutum
37,915 11-Jun-99 similar to (U64918) ATGP1 [Arabidopsis thaliana],
mRNA sequence. GB_BA2: AF030176 7000 AF030176 Rhodococcus opacus
putative transposase gene, partial cds; and putative Rhodococcus
opacus 37,127 5-Aug-98 FAD synthetase, putative short-chain
dehydrogenase/reductase, maleylacetate reductase (macA), and
putative transcription factor genes, complete cds. rxa01825 393
GB_HTG1: HSJCF13 293368 AJ239320 Homo sapiens chromosome X clone
cosmid 244B12 map Xq13, *** SEQUENCING Homo sapiens 34,748
28-Sep-99 IN PROGRESS ***, in ordered pieces. GB_HTG1: HSJCF13
293368 AJ239320 Homo sapiens chromosome X clone cosmid 244B12 map
Xq13, *** SEQUENCING Homo sapiens 34,748 28-Sep-99 IN PROGRESS ***,
in ordered pieces. GB_HTG1: AP000568 136627 AP000568 Homo sapiens
chromosome 21 clone B753B2 map 21q21.2, *** SEQUENCING Homo sapiens
34,884 07-OCT-1999 IN PROGRESS ***, in unordered pieces. rxa01831
585 GB_IN2: AF047757 408 AF047757 Trichogramma australicum internal
transcribed spacer 2, complete sequence. Trichogramma australicum
38,39 10-Jul-98 GB_EST18: AA687516 513 AA687516 ns58h11.r1
NCI_CGAP_Pr22 Homo sapiens cDNA clone IMAGE: 1187877 5' Homo
sapiens 35,057 11-DEC-1997 similar to gb: X15341 CYTOCHROME C
OXIDASE POLYPEPTIDE VIA-LIVER (HUMAN);, mRNA sequence. GB_EST18:
AA687516 513 AA687516 ns58h11.r1 NCI_CGAP_Pr22 Homo sapiens cDNA
clone IMAGE: 1187877 5' Homo sapiens 37,624 11-DEC-1997 similar to
gb: X15341 CYTOCHROME C OXIDASE POLYPEPTIDE VIA-LIVER (HUMAN);,
mRNA sequence. rxa01834 825 GB_PL2: T8F5 87192 AC004512 Arabidopsis
thaliana chromosome 1 BAC T8F5 sequence, complete sequence.
Arabidopsis thaliana 38,101 22-Jul-98 GB_PR4: AC007677 166949
AC007677 Homo sapiens clone NH0086N01, complete sequence. Homo
sapiens 35,888 28-Sep-99 GB_PR4: AC007677 166949 AC007677 Homo
sapiens clone NH0086N01, complete sequence. Homo sapiens 36,906
28-Sep-99 rxa01842 1041 GB_HTG3: AC009183 145694 AC009183
Drosophila melanogaster chromosome 3 clone BACR39F04 (D839)
Drosophila melanogaster 40,43 16-Sep-99 RPCI-98 39.F.4 map 85F-85F
strain y; cn bw sp. *** SEQUENCING IN PROGRESS***, 139 unordered
pieces. GB_HTG3: AC009183 145694 AC009183 Drosophila melanogaster
chromosome 3 clone BACR39F04 (D839) Drosophila melanogaster 40,43
16-Sep-99 RPCI-98 39.F.4 map 85F-85F strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 139 unordered pieces. GB_HTG5: AC008338
136685 AC008338 Drosophila melanogaster chromosome X clone
BACR30J04 (D908) Drosophila melanogaster 40,527 15-Nov-99 RPCI-98
30.J.4 map 19C-19E strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 93 unordered pieces. rxa01844 303 GB_HTG2: AC007597 163880
AC007597 Homo sapiens chromosome 16 clone RPCI-11_137H10, ***
SEQUENCING Homo sapiens 34,564 20-Jul-99 IN PROGRESS ***, 3 ordered
pieces. GB_HTG2: AC007597 163880 AC007597 Homo sapiens chromosome
16 clone RPCI-11_137H10, *** SEQUENCING IN Homo sapiens 34,564
20-Jul-99 PROGRESS ***, 3 ordered pieces. GB_HTG3: AC009998 163590
AC009998 Homo sapiens chromosome 15 clone BAC 573G7 map 15q24, Homo
sapiens 40,816 10-Sep-99 LOW-PASS SEQUENCE SAMPLING. rxa01845 531
GB_OV: AF012348 4921 AF012348 Gallus gallus smooth muscle gamma
actin (gamma actin) gene, complete cds. Gallus gallus 37,333
17-MAR-1998 GB_BA1: D85417 7984 D85417 Propionibacterium
freudenreichii hemY, hemH, hemB, hemX, hemR and hemL
Propionibacterium 45,243 6-Feb-99 genes, complete cds.
freudenielchii GB_BA1: D85417 7984 D85417 Propionibacterium
freudenreichii hemY, hemH, hemB, hemX, hemR and hemL
Propionibacterium 40,232 6-Feb-99 genes, complete cds.
freudenreichii rxa01846 382 GB_HTG1: HSJ323A24 278948 AL121750 Homo
sapiens chromosome 4 clone RP3-323A24, *** SEQUENCING Homo sapiens
34,84 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1:
HSJ323A24 278948 AL121750 Homo sapiens chromosome 4 clone
RP3-323A24, *** SEQUENCING Homo sapiens 34,84 23-Nov-99 IN PROGRESS
***, in unordered pieces. GB_PR2: HS181C9 92472 Z98743 Human DNA
sequence from clone 181C9 on chromosome Homo sapiens 42,48
23-Nov-99 22q13.2-13.33. Contains a PHAPI2 Leucine Rich Acidic
Nuclear Protein pseudogene,
part of a putative novel gene, ESTs, STSs and GSSs, complete
sequence. rxa01847 858 GB_PR3: AC004893 103738 AC004893 Homo
sapiens PAC clone DJ0808A01 from 7q21.1-q31.1, complete sequence.
Homo sapiens 38,321 03-OCT-1998 GB_HTG4: AC010182_3 110000 AC010182
Homo sapiens chromosome 12q seeders clone RPCI11-185N2, ***
SEQUENCING Homo sapiens 36,998 15-Sep-99 IN PROGRESS ***, 172
unordered pieces. GB_HTG4: AC010182_3 110000 AC010182 Homo sapiens
chromosome 12q seeders clone RPCI11-185N2, *** SEQUENCING Homo
sapiens 36,998 15-Sep-99 IN PROGRESS ***, 172 unordered pieces.
rxa01856 669 GB_GSS15: AQ612487 433 AQ612487 HS_5122_A1_B07_SP6E
RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 39,723
15-Jun-99 genomic clone Plate = 698 Col = 13 Row = C, genomic
survey sequence. GB_PR4: AC005876 89817 AC005876 citb_188_i_5,
complete sequence. Homo sapiens 39,567 5-Nov-99 GB_PR4: AC005876
89817 AC005876 citb_188_i_5, complete sequence. Homo sapiens 36,677
5-Nov-99 rxa01857 774 GB_PR3: HS742C19 122748 AL031846 Human DNA
sequence from clone RP4-742C19 on Homo sapiens 33,506 29-Nov-99
chromosome 22, complete sequence. GB_PR2: HSJ1100I6 161525 AL110503
Human DNA sequence from clone RP5-1100I6 on chromosome 20 Homo
sapiens 37,45 22-Nov-99 Contains a novel mRNA, GSSs and a CpG
Island, complete sequence. GB_HTG6: AC009893 186769 AC009893 Homo
sapiens chromosomes 8 clone RP11-4P3, *** SEQUENCING Homo sapiens
37,368 23-Nov-99 IN PROGRESS ***, 5 unordered pieces. rxa01858
rxa01870 798 GB_RO: AC004155 128026 AC004155 Mus musculus DNA from
BAC 10818 containing the Ercc-4 gene, complete sequence. Mus
musculus 37,387 19-Feb-98 GB_RO: AC004155 128026 AC004155 Mus
musculus DNA from BAC 10818 containing the Ercc-4 gene, complete
sequence. Mus musculus 37,707 19-Feb-98 GB_BA2: AF144563 5971
AF144563 Thermobilida fusca beta-1,4-exocellulase E6 precursor
(celF) gene, Thermobifida fusca 38,619 21-Jun-99 complete cds; and
unknown genes. rxa01871 1086 GB_BA2: AF079304 3350 AF079304
Eikenella corrodens type IV pilin (pilA1), type IV pilin (pilA2),
putative Eikenelia corrodens 40,465 15-Jul-99 fimbrial prbtein
(pilB), and putative hemagglutinin protein (hagA) genes, complete
cds. GB_BA1: ECECPHAG 3589 Z12609 E. corrodens ecpA and ecpB genes
encoding type 4 N-methylphenylalanine pilin and Eikenelia corrodens
40,517 5-Aug-92 hag1 gene for hemagglutinin protein. GB_BA2:
AE001707 19518 AE001707 Thermotoga maritima section 19 of 136 of
the complete genome. Thermotoga maritima 38,124 2-Jun-99 rxa01874
448 GB_EST6: N51407 505 N51407 yz17a08.s1
Soares_multiple_sclerosis_2NbHMSP Homo sapiens Homo sapiens 35,735
14-Feb-96 cDNA clone IMAGE: 283286 3', mRNA sequence. GB_EST29:
AI619782 374 AI619782 ty53b03.x1 NCI_CGAP_Ut2 Homo sapiens cDNA
clone Homo sapiens 38,966 21-Apr-99 IMAGE: 2282765 3', mRNA
sequence. GB_EST36: AI885047 466 AI865047 wl89a01.x1 NCI_CGAP_Brn25
Homo sapiens cDNA clone Homo sapiens 37,419 1-Sep-99 IMAGE: 2432040
3', mRNA sequence. rxa01875 969 GB_EST13: AA356276 291 AA356276
EST64843 Jurkat T-cells VI Homo sapiens cDNA 5' end, mRNA sequence.
Homo sapiens 41,667 21-Apr-97 GB_EST22: AI050653 443 AI050653
ub38f03.r1 Soares 2NbMT Mus musculus cDNA clone Mus musculus 38,851
9-Jul-98 IMAGE: 1380029 5', mRNA sequence. GB_GSS1: CNS0022Z 1101
AL061786 Drosophila melanogaster genome survey sequence T7 end of
BAC # Drosophila melanogaster 39,039 3-Jun-99 BACR05B21 of RPCI-98
library from Drosophila melanogaster (fruit fly), genomic survey
sequence. rxa01877 1194 GB_HTG4: AC009849 114993 AC009849
Drosophila melanogaster chromosome 2 clone BACR07H08 (D864)
Drosophila melanogaster 37,274 25-OCT-1999 RPCI-98 07.H.8 map
31B-31C strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 55
unordered pieces. GB_HTG4: AC009849 114993 AC009849 Drosophila
melanogaster chromosome 2 clone BACR07H08 (D864) Drosophila
melanogaster 37,274 25-OCT-1999 RPCI-98 07.H.8 map 31B-31C strain
y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 55 unordered pieces.
GB_IN2: AC005454 84367 AC005454 Drosophila melanogaster, chromosome
2R, region 31C1-31D6, Drosophila melanogaster 38,679 15-DEC-1998 P1
clone DS08879, complete sequence. rxa01879 1056 GB_PR2: CNS0000Q
192932 AL049874 Human chromosome 14 DNA sequence *** IN PROGRESS
*** BAC Homo sapiens 37,094 7-Jul-99 R-1042B17 of RPCI-11 library
from chromosome 14 of Homo sapiens (Human), complete sequence.
GB_HTG2: AC006732 159453 AC006732 Caenorhabditis elegans clone
Y32G9, *** SEQUENCING Caenorhabditis elegans 34,862 23-Feb-99 IN
PROGRESS ***, 9 unordered pieces. GB_HTG2: AC006732 159453 AC006732
Caenorhabditis elegans clone Y32G9, *** SEQUENCING Caenorhabditis
elegans 34,862 23-Feb-99 IN PROGRESS ***, 9 unordered pieces.
rxa01896 759 GB_BA1: SC2G5 38404 AL035478 Streptomyces coelicolor
cosmid 2G5. Streptomyces coelicolor 38,42 11-Jun-99 GB_PL1:
AP000570 157903 AP000570 Oryza sativa genomic DNA, Oryza sativa
40,272 03-DEC-1999 chromosome 1, clone: P0711E10. GB_BA1: SC2G5
38404 AL035478 Streptomyces coelicolor cosmid 2G5. Streptomyces
coelicolor 40,27 11-Jun-99 rxa01899 909 GB_BA1: MTV002 56414
AL008967 Mycobacterium tuberculosis H37Rv complete genome; segment
122/162. Mycobacterium 38,702 17-Jun-98 tuberculosis GB_BA1: MTV002
56414 AL008967 Mycobacterium tuberculosis H37Rv complete genome;
segment 122/162. Mycobacterium 38,229 17-Jun-98 tuberculosis
rxa01902 1182 GB_HTG6: AC009893 186769 AC009893 Homo sapiens
chromosome 8 clone RP11-4P3, *** SEQUENCING Homo sapiens 34,868
23-Nov-99 IN PROGRESS ***, 5 unordered pieces. GB_OV: D84063 2363
D84063 Oryzias latipes Bf/C2 mRNA, complete cds. Oryzias latipes
38,074 6-Feb-99 GB_HTG6: AC009893 186769 AC009893 Homo sapiens
chromosome 8 clone RP11-4P3, *** SEQUENCING Homo sapiens 35,616
23-Nov-99 IN PROGRESS ***, 5 unordered pieces. rxa01903 302 GB_BA1:
MSGILVB 4210 L49392 Mycobacterium avium acetolactate synthase
(ilvBN) and acetohydroxy acid Mycobacterium avium 38,667
11-DEC-1996 isomeroreductase (ilvC) gene, complete cds. GB_PR3:
AC004833 68890 AC004833 Homo sapiens PAC clone DJ0547C10 from
7p21-p22, complete sequence. Homo sapiens 34,815 5-Nov-98 GB_PR3:
AC004833 68890 AC004833 Homo sapiens PAC clone DJ0547C10 from
7p21-p22, complele sequence. Homo sapiens 42,712 5-Nov-98 rxa01904
546 GB_HTG2: AC006740 200965 AC006740 Caenorhabditis elegans clone
Y38B5, *** SEQUENCING Caenorhabditis elegans 34,074 25-Feb-99 IN
PROGRESS ***, 12 unordered pieces. GB_HTG2: AC006695 33622 AC006695
Caenorhabditis elegans clone W06H8, *** SEQUENCING Caenorhabditis
elegans 35,556 23-Feb-99 IN PROGRESS ***, 1 unordered pieces.
GB_HTG2: AC006695 33622 AC006695 Caenorhabditis elegans clone
W06H8, *** SEQUENCING Caenorhabditis elegans 35,556 23-Feb-99 IN
PROGRESS ***, 1 unordered pieces. rxa01905 654 GB_IN1: CEW04G3
32158 Z68014 Caenorhabditis elegans cosmid W04G3, complete
sequence. Caenorhabditis elegans 38,73 2-Sep-99 GB_PL2: AF067082
6947 AF067082 Apium graveolens mannitol dehydrogenase (Mtd) gene,
complete cds. Apium graveolens 38,242 30-Sep-98 GB_IN1: CEW04G3
32158 Z68014 Caenorhabditis elegans cosmid W04G3, complete
sequence. Caenorhabditis elegans 38,834 2-Sep-99 rxa01906 588
GB_PL1: AB012242 78973 AB012242 Arabidopsis thaliana genomic DNA,
chromosome 5, TAC clone: Arabidopsis thaliana 39,071 20-Nov-99
K24G6, complete sequence. GB_EST6: N49608 454 N49608 yy58g01.s1
Soares_multiple_sclerosis_2NbHMSP Homo sapiens cDNA Homo sapiens
43,603 14-Feb-96 clone IMAGE: 277776 3', mRNA sequence. GB_EST6:
N49609 452 N49609 yy58g02.s1 Soares_multiple_sclerosis_2NbHMSP Homo
sapiens cDNA Homo sapiens 43,307 14-Feb-98 clone IMAGE: 277778 3',
mRNA sequence. rxa01907 735 GB_HTG3: AC009437 159691 AC009437 Homo
sapiens chromosome 11 clone 56_G_09 map 11, *** SEQUENCING Homo
sapiens 36,226 22-Aug-99 IN PROGRESS ***, 10 unordered pieces.
GB_HTG3: AC009437 159691 AC009437 Homo sapiens chromosome 11 clone
56_G_09 map 11, *** SEQUENCING Homo sapiens 36,226 22-Aug-99 IN
PROGRESS ***, 10 unordered pieces. GB_HTG3: AC009437 159691
AC009437 Homo sapiens chromosome 11 clone 56_G_09 map 11, ***
SEQUENCING Homo sapiens 38,483 22-Aug-99 IN PROGRESS ***, 10
unordered pieces. rxa01908 969 GB_PR3: HS90G24 154414 AL008723
Human DNA sequence from clone 90G24 on chromosome 22. Homo sapiens
37,331 23-Nov-99 Contains the RFPL2 gene for RET finger
protein-like 2, an Immunoglobulin Lambda Light Chain C region
(IGLC) pseudogene, the gene for SAAT1 (low affinity sodium glucose
cotransporter (sodium: solute symporter family)) and a Cleavage and
Polyadenylation Specific Factor CPSF 160 kD subunit pseudogene.
Contains ESTs, GSSs and three putative CpG islands, complete
sequence. GB_EST25: AI316482 972 AI316482 uj60g12.y1 Sugano mouse
liver mlia Mus musculus cDNA clone IMAGE: Mus musculus 36,8
17-DEC-1998 1924390 5' similar to gb: M12529 APOLIPOPROTEIN E
PRECURSOR (HUMAN); gb: D00466 Mouse apolipoprotein E gene (MOUSE);,
mRNA sequence. GB_EST27: AI398904 556 AI398904 NCW10G7T7
Westergaards Neurospora crassa cDNA Neurospora crassa 38,095
8-Feb-99 clone W10G7 3', mRNA sequence. rxa01909 970 GB_HTG1:
HSJ658I14 133423 AL109845 Homo sapiens chromosome 1 clone
RP4-658I14, *** SEQUENCING Homo sapiens 40,52 23-Nov-99 IN PROGRESS
***, in unordered pieces. GB_HTG1: HSJ658I14 133423 AL109845 Homo
sapiens chromosome 1 clone RP4-658I14, *** SEQUENCING Homo sapiens
40,52 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1:
HSJ658I14 133423 AL109845 Homo sapiens chromosome 1 clone
RP4-658I14, *** SEQUENCING Homo sapiens 36,364 23-Nov-99 IN
PROGRESS ***, in unordered pieces. rxa01910 969 GB_PR2: CNS00008
218956 AL049831 Human chromosome 14 DNA sequence *** IN PROGRESS
*** Homo sapiens 35,393 29-Jun-99 BAC R-330O19 of RPCI-11 library
from chromosome 14 of Homo sapiens (Human), complete sequence.
GB_PR2: CNS00008 218956 AL049831 Human chromosome 14 DNA sequence
*** IN PROGRESS *** Homo sapiens 38,405 29-Jun-99 BAC R-330O19 of
RPCI-11 library from chromosome 14 of Homo sapiens (Human),
complete sequence. GB_HTG5: AC009217 118561 AC009217 Drosophila
melanogaster chromosome X clone BACR41N19 (D907) Drosophila
melanogaster 36,765 16-Nov-99 RPCI-98 41.N.19 map 19A-19C strain y;
cn bw sp, *** SEQUENCING IN PROGRESS ***, 78 unordered pieces.
rxa01911 1062 GB_HTG2: AC002317 94882 AC002317 Homo sapiens
chromosome 17 clone HCIT7H10 map 17, *** SEQUENCING Homo sapiens
36,654 20-Feb-98 IN PROGRESS ***, 8 unordered pieces. GB_HTG2:
AC002317 94882 AC002317 Homo sapiens chromosome 17 clone HCIT7H10
map 17, *** SEQUENCING Homo sapiens 36,654 20-Feb-98 IN PROGRESS
***, 8 unordered pieces. GB_HTG2: AC002317 94882 AC002317 Homo
sapiens chromosome 17 clone HCIT7H10 map 17, *** SEQUENCING Homo
sapiens 37,012 20-Feb-98 IN PROGRESS ***, 8 unordered pieces.
rxa01923 873 GB_HTG2: AC006844 299782 AC006844 Caenorhabditis
elegans clone Y108G3Y, *** SEQUENCING Caenorhabditis elegans 37,176
24-Feb-99 IN PROGRESS ***, 4 unordered pieces. GB_HTG2: AC006844
299782 AC006844 Caenorhabditis elegans clone Y108G3Y, ***
SEQUENCING Caenorhabditis elegans 37,176 24-Feb-99 IN PROGRESS ***,
4 unordered pieces. GB_BA1: ECOUW76 225419 U00039 E. coli
chromosomal region from 76.0 to 81.5 minutes. Escherichia coli
38,902 7-Nov-98 rxa01930 1074 GB_BA1: CGPAN 2164 X96580 C.
glutamicum panB, panC & xylB genes. Corynebacterium 100
11-MAY-1999 glutamicum GB_HTG2: AC007598 248427 AC007598 Homo
sapiens chromosome 16 clone 165M1, *** SEQUENCING Homo sapiens
38,469 20-MAY-1999 IN PROGRESS ***, 105 unordered pieces. GB_HTG2:
AC007598 248427 AC007598 Homo sapiens chromosome 16 clone 165M1,
*** SEQUENCING Homo sapiens 38,469 20-MAY-1999 IN PROGRESS ***, 105
unordered pieces. rxa01931 777 GB_IN1: CEH12I19 37427 Z98851
Caenorhabditis elegans cosmid H12I19, complete sequence.
Caenorhabditis elegans 32,763 18-DEC-1998 GB_HTG1: CEY37A1 316170
Z93243 Caenorhabditis elegans chromosome IV clone Y37A1, ***
SEQUENCING Caenorhabditis elegans 32,763 03-DEC-1998 IN PROGRESS
***, in unordered pieces. GB_HTG1: CEY37A1 316170 Z93243
Caenorhabditis elegans chromosome IV clone Y37A1, *** SEQUENCING
Caenorhabditis elegans 32,763 03-DEC-1998 IN PROGRESS ***, in
unordered pieces. rxa01941 558 GB_EST25: AI313927 520 AI313927
uj38h06.x1 Sugano mouse kidney mkia Mus musculus cDNA clone Mus
musculus 41,148 17-DEC-1998 IMAGE: 1922267 3' similar to TR: O09047
O09047 COMPLEMENT COMPONENT 3A RECEPTOR 1;, mRNA sequence. GB_RO:
AF053757 8308 AF053757 Mus musculus complement C3a anaphylatoxin
receptor (C3ar) gene, complete cds. Mus musculus 38,649 30-Jul-98
GB_RO: MMU77461 2657 U77461 Mus musculus anaphylatoxin C3a receptor
gene, complete cds. Mus musculus 38,649 28-MAY-1997 rxa01942 723
GB_BA1: BRLPTSG 3163 L18875 Brevibacterium lactofermentum
phosphoenolpyruvate sugar Brevibacterium 67,407 01-OCT-1993
phosphotransferase (ptsG) gene, complete cds. lactofermentum
GB_BA1: CORPTSMA 2656 L18874 Corynebacterium glutamicum
phosphoenolpyruvate sugar Corynebacterium 100 24-Nov-94
phosphotransferase (ptsM) mRNA, complete cds. glutamicum GB_BA1:
CORPTSMA 2656 L18874 Corynebacterium glutamicum phosphoenolpyruvate
sugar Corynebacterium 37,008 24-Nov-94 phosphotransferase (ptsM)
mRNA, complete cds. glutamicum rxa01944 1095 GB_HTG2: AC004840
162485 AC004840 Homo sapiens clone DJ0607J02, *** SEQUENCING Homo
sapiens 36,287 12-Jun-98 IN PROGRESS ***, 12 unordered pieces.
GB_HTG2: AC004840 162485 AC004840 Homo sapiens clone DJ0607J02, ***
SEQUENCING Homo sapiens 36,287 12-Jun-98 IN PROGRESS ***, 12
unordered pieces. GB_VI:MCU60315 190289 U60315 Molluscum
contagiosum virus subtype 1, complete genome. Molluscum contagiosum
37,65 17-Aug-96 virus subtype 1
rxa01945 2115 GB_GSS15: AQ632158 445 AQ632158 RPCI-11-473F7.TJ
RPCI-11 Homo sapiens genomic clone Homo sapiens 38,095 17-Jun-99
RPCI-11-473F7, genomic survey sequence. GB_GSS15: AQ632158 445
AQ632158 RPCI-11-473F7.TJ RPCI-11 Homo sapiens genomic clone Homo
sapiens 40,275 17-Jun-99 RPCI-11-473F7, genomic survey sequence.
rxa01957 585 GB_EST16: C35275 300 C35275 C35275 Yuji Kohara
unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis
elegans 37,698 18-OCT-1999 Caenorhabditis elegans cDNA clone
yk427e6 3', mRNA sequence. GB_IN2: CELC29H12 42635 U23169
Caenorhabditis elegans cosmid C29H12. Caenorhabditis etegans 34,477
13-Jul-95 GB_GSS1: CNS00GP0 1101 AL072364 Drosophila melanogaster
genome survey sequence T7 end of BAC: Drosophila melanogaster
34,321 3-Jun-99 BACR33I08 of RPCI-98 library from Drosophila
melanogaster (fruit fly), genomic survey sequence. rxa01958 630
GB_PR1: HSIL1RECA 12565 X64532 H. sapiens gene for interleukin-1
receptor antagonist. Homo sapiens 42,079 25-Jun-97 GB_PR3: HSU65590
33414 U65590 Homo sapiens IL-1 receptor antagonist IL-1Ra (IL-1RN)
gene, Homo sapiens 42,079 21-DEC-1997 alternatively spliced forms,
complete cds. GB_GSS11: AQ293677 476 AQ293677 HS_2254_A2_C03_MF CIT
Approved Human Genomic Sperm Library D Homo sapiens 36,772
15-DEC-1998 Homo sapiens genomic clone Plate = 2254 Col = 6 Row =
E. genomic survey sequence. rxa01959 rxa01960 rxa01961 603 GB_BA2:
U67460 12589 U67460 Methanococcus jannaschii section 2 of 150 of
the complete genome. Methanococcus jannaschii 36,013 26-Jan-98
GB_EST25: AI260761 626 AI260761 LP04729.3prime LP Drosophila
melanogaster larval-early pupal pOT2 Drosophila melanogaster 39,13
17-Nov-98 Drosophila melanogaster cDNA clone LP04729 3prime, mRNA
sequence. GB_EST25: AI294890 554 AI294890 LP08371.3prime LP
Drosophila melanogaster larval-early pupal pOT2 Drosophila
melanogaster 38,94 01-DEC-1998 Drosophila melanogaster cDNA clone
LP08371 3prime. mRNA sequence. rxa01962 693 GB_BA2: U67460 12589
U67460 Methanococcus jannaschii section 2 of 150 of the complete
genome. Methanococcus jannaschii 34,795 28-Jan-98 GB_BA2: U67460
12589 U67460 Methanococcus Jannaschii section 2 of 150 of the
complete genome. Methanococcus Jannaschii 37,666 26-Jan-98 rxa01963
784 GB_PR4: AC006397 91460 AC006397 Homo sapiens BAC clone GS170I02
from 7p21-p15.1, complete sequence. Homo sapiens 35,401 17-Feb-99
GB_PR3: AC005565 39441 AC005565 Homo sapiens chromosome 16, cosmid
clone 444B9 (LANL), complete sequence. Homo sapiens 37,891
30-Aug-98 GB_PR2: D86999 40778 D86999 Homo sapiens immunoglobulin
lambda gene locus DNA, clone: 22A12. Homo sapiens 38,212 5-Nov-99
rxa01964 1426 GB_GSS13: AQ465174 437 AQ465174 HS_5109_A2_C07_SP6E
RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 40,084
23-Apr-99 genomic clone Plate = 685 Col = 14 Row = E, genomic
survey sequence. GB_GSS13: AQ457528 599 AQ457528
HS_5087_A1_H06_SP6E RPCI-11 Human Male BAC Library Homo sapiens
Homo sapiens 36,728 23-Apr-99 genomic clone Plate = 663 Col = 11
Row = O, genomic survey sequence. GB_GSS13: AQ454028 527 AQ454028
HS_5171_B1_D12_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo
sapiens 37,137 21-Apr-99 genomic clone Plate = 747 Col = 23 Row =
H, genomic survey sequence. rxa01965 684 GB_IN2: AC004283 80095
AC004283 Drosophila melanogaster DNA sequence (P1 DS05557 (D152)),
complete sequence. Drosophila melanogaster 36,982 29-Aug-98
GB_EST25: AI541584 585 AI541584 SD02734.5prime SD Drosophila
melanogaster Schneider L2 cell culture Drosophila melanogastar
38,375 22-MAR-1999 pOT2 Drosophila melanogaster cDNA clone SD02734
5prime, mRNA sequence. GB_EST22: AI013385 434 AI013385 EST208060
Normalized rat spleen, Bento Soares Rattus sp. cDNA clone Rattus
sp. 42,126 31-Jan-99 RSPBK32 3' end, mRNA sequence. rxa01966 780
GB_GSS1: CNS00AMI 810 AL055260 Drosophila melanogaster genome
survey sequence TET3 end of BAC # Drosophila melanogaster 37,592
4-Jun-99 BACR21F10 of RPCI-98 library from Drosophila melanogaster
(fruit fly), genomic survey sequence. GB_HTG3: AC009567 164147
AC009587 Homo sapiens chromosome 4 clone 21_G_20 map 4, ***
SEQUENCING Homo sapiens 35,844 29-Sep-99 IN PROGRESS ***, 14
unordered pieces. GB_HTG3: AC009567 164147 AC009567 Homo sapiens
chromosome 4 clone 21_G_20 map 4, *** SEQUENCING Homo sapiens
35,844 29-Sep-99 IN PROGRESS ***, 14 unordered pieces. rxa01968
1281 GB_PR4: AC005146 157653 AC005146 Homo sapiens 12q24.2 PAC
RPCI1.157K6 (Roswell Park Cancer Homo sapiens 40,62 11-Nov-98
Institute Human PAC library) complete sequence. GB_PR4: AC006549
174844 AC006549 Homo sapiens, complete sequence. Homo sapiens
34,202 26-Nov-99 GB_PR2: HSAC002070 165197 AC002070 Human BAC clone
7E17 from 12q, complete sequence. Homo sapiens 36,482 12-MAY-1997
rxa01969 489 GB_SY: SCU53587 4546 U53587 Artificial Corynebacterium
glutamicum IS1207-derived transposon synthetic construct 98,16
06-MAY-1996 transposase genes, complete cds, and
3'5''-aminoglycoside phosphotransferase (aphA-3) gene, complete
cds. GB_PAT: I43826 1452 I43826 Sequence 1 from patent U.S. Pat.
No. 5633154. Unknown. 98,963 07-OCT-1997 GB_BA1: CGIS1207 1453
X96962 C. glutamicum Insertion sequence IS1207 and transposase
gene. Corynebacterium 98,755 01-MAY-1997 glutamicum rxa01973
rxa01974 1908 GB_PL1: SC9320A 24000 Z68329 S. cerevisiae chromosome
IV cosmid 9320A. Saccharomyces cerevisiae 36,528 11-Aug-97 GB_PL1:
SC9320X 22253 Z70202 S. cerevisiae chromosome IV cosmid 9320X.
Saccharomyces cerevisiae 36,528 11-Aug-97 GB_PR4: AC006210 186986
AC006210 Homo sapiens Xp22-150 BAC GSHB-309P15 (Genome Systems Homo
sapiens 38,351 31-DEC-1998 Human BAC Library) complete sequence.
rxa01976 1644 GB_BA2: CGU13922 4412 U13922 Corynebacterium
glutamicum putative type II 5-cytosoine Corynebacterium 47,727
3-Feb-98 methyltransferase (cgliM) and putative type II restriction
endonuclease (cgIIR) and glutamicum putative type I or type III
restriction endonuclease CglIIR) genes, complete cds. GB_BA2:
CGU13922 4412 U13922 Corynebacterium glutamicum putative type II
5-cytosoine methyltransferase (cglIM) Corynebacterium 37,515
3-Feb-98 and putative type II restriction endonuclease (cgIIR) and
putative type I or type glutamicum III restriction endonuclease
(clgIIR) genes, complete cds. rxa01977 699 GB_PR3: HS426F10 91640
AL023586 Human DNA sequence from clone 426F10 on chromosome Homo
sapiens 38,295 23-Nov-99 1p36.21-36.33 Contains EST, CA repeat,
STS, complete sequence. GB_GSS6: AQ823696 587 AQ823696
HS_3228_A1_D10_T7C CIT Approved Human Genomic Sperm Homo sapiens
37,637 26-Aug-99 Library D Homo sapiens genomic clone Plate = 3228
Col = 19 Row = G, genomic survey sequence. GB_VI: HS3DNA1 892
M29629 Varicella-zoster virus (VZV) DNA, 5'end. Human herpesvirus 3
33,857 2-Aug-93 rxa01982 1281 GB_EST8: AA009257 472 AA009257
mh02g07.r1 Soares mouse embryo NbME13.5 14.5 Mus musculus cDNA
clone Mus musculus 36,017 26-Jul-96 IMAGE: 441372 5', mRNA
sequence. GB_EST8: AA009257 472 AA009257 mh02g07.r1 Soares mouse
embryo NbME13.5 14.5 Mus musculus cDNA clone Mus musculus 38,71
26-Jul-96 IMAGE: 441372 5', mRNA sequence. rxa01987 336 GB_PR4:
AC009330 174768 AC009330 Homo sapiens clone RP11-83M17 from 7q31,
complete sequence. Homo sapiens 33,036 09-DEC-1999 GB_HTG6:
AC007300 171472 AC007300 Drosophila melanogaster chromosome 2 clone
BACRO9I15(D570) Drosophila melanogaster 38,782 07-DEC-1999 RPCI-98
09.I.15 map 32A-32A strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 43 unordered pieces. GB_HTG3: AC009542 160367 AC009542 Homo
sapiens chromosome 7, *** SEQUENCING IN Homo sapiens 35,065
27-Aug-99 PROGRESS ***, 17 unordered pieces. rxa01988 549 GB_IN1:
AC002446 50978 AC002446 Drosophila melanogaster (P1 DS06754 (D83))
DNA sequence, complete sequence. Drosophila melanogaster 38,92
19-Aug-97 GB_PR3: HSU19H10 43303 AL021182 Human DNA sequence from
cosmid U19H10 on chromosome X. Homo sapiens 39,006 23-Nov-99
Contains ESTs and CA repeat. GB_PR3: HSU19H10 43303 AL021182 Human
DNA sequence from cosmid U19H10 on chromosome X. Homo sapiens
38,447 23-Nov-99 Contains ESTs and CA repeat. rxa01990 1022
GB_GSS9: AQ100628 382 AQ100628 HS_3054_B2_A05_MF CIT Approved Human
Genomic Sperm Library Homo sapiens 38,32 27-Aug-98 D Homo sapiens
genomic clone Plate = 3054 Col = 10 Row = B, genomic survey
sequence. GB_EST14: AA406679 338 AA406679 MBAFCZ2F12T3A Brugla
malayi adult female cDNA(SAW96MLW-BmAF) Brugia malayi 38,039
01-MAY-1997 Brugia malayi cDNA clone AFCZ2F12 5', mRNA sequence.
GB_EST21: AA991134 600 AA991134 BSBmMFSZ06C1SK Brugia malayi
microfilaria cDNA Brugia alayi 40,09 5-Jun-88 (SAW94LS-BmMf) Brugia
malayi cDNA clone BSBmMFSZ06C1 5', mRNA sequence. rxa01991 996
GB_HTG3: AC007559 156374 AC007559 Homo sapiens clone NH0364J06, ***
SEQUENCING IN Homo sapiens 35,931 13-Aug-99 PROGRESS ***, 29
unordered pieces. GB_HTG3: AC007559 156374 AC007559 Homo sapiens
clone NH0364J06, *** SEQUENCING IN Homo sapiens 35,931 13-Aug-99
PROGRESS ***, 29 unordered pieces. GB_HTG3: AC007559 156374
AC007559 Homo sapiens clone NH0364J06, *** SEQUENCING Homo sapiens
36,12 13-Aug-99 IN PROGRESS ***, 29 unordered pieces. rxa01992
rxa01996 660 GB_BA1: XCXPSGEN 5324 X59079 X. campestris xps E, F,
G, H, I, and J genes for protein secretion Xanthomonas campestris
38,447 12-Sep-93 and pathogenicity functions. GB_GSS15: AQ659461
394 AQ659461 Sheared DNA-5C7.TR Sheared DNA Trypanosoma brucel
Trypanosoma brucei 49,18 23-Jun-99 genomic clone Sheared DNA-5C7,
genomic survey sequence. GB_GSS4: AQ741049 713 AQ741049
HS_2272_A2_B02_MR CIT Approved Human Genomic Sperm Homo sapiens
39,614 16-Jul-99 Library D Homo sapiens genomic clone Plate = 2272
Col = 4 Row = C, genomic survey sequence. rxa01999 594 GB_HTG2:
AC007321 159558 AC007321 Homo sapiens clone NH0507C01, ***
SEQUENCING IN Homo sapiens 34,524 16-Apr-99 PROGRESS ***, 4
unordered pieces. GB_HTG2: AC007321 159558 AC007321 Homo sapiens
clone NH0507C01, *** SEQUENCING IN Homo sapiens 34,524 16-Apr-99
PROGRESS ***, 4 unordered pieces. GB_HTG2: AC007321 159558 AC007321
Homo sapiens clone NH0507C01, *** SEQUENCING IN Homo sapiens 35,094
16-Apr-99 PROGRESS ***, 4 unordered pieces. rxa02001 1281 GB_BA1:
D90917 154619 D90917 Synechocystis sp. PCC6803 complete genome,
27/27, 3418852-3573470. Synechocystis sp. 50,474 7-Feb-99 GB_BA1:
MTV016 53662 AL021841 Mycobacterium tuberculosis H37Rv complete
genome; segment 143/162. Mycobacterium 39,223 23-Jun-99
tuberculosis GB_BA1: BSUB0006 210440 Z99109 Bacillus subtilis
complete genome (section 6 of 21): from 999501 to 1209940. Bacillus
subtilis 36,445 26-Nov-97 rxa02004 230 GB_HTG3: AC011491 162134
AC011491 Homo sapiens chromosome 19 clone CIT978SKB_180A7, ***
SEQUENCING Homo sapiens 37,383 07-OCT-1999 IN PROGRESS ***, 161
unordered pieces. GB_HTG3: AC011491 162134 AC011491 Homo sapiens
chromosome 19 clone CIT978SKB_180A7, Homo sapiens 37,383
07-OCT-1999 *** SEQUENCING IN PROGRESS ***, 161 unordered pieces.
GB_HTG3: AC011357 160676 AC011357 Homo sapiens chromosome 5 clone
CIT-HSPC_362D12, *** SEQUENCING IN Homo sapiens 54,585 06-OCT-1999
PROGRESS ***, 42 unordered pieces. rxa02006 595 GB_HTG2: AC006901
294136 AC006901 Caenorhabditis elegans clone Y74A11X, ***
SEQUENCING Caenorhabditis elegans 37,5 26-Feb-99 IN PROGRESS ***,
81 unordered pieces. GB_HTG2: AC006901 294136 AC006901
Caenorhabditis elegans clone Y74A11X, *** SEQUENCING IN
Caenorhabditis elegans 37,5 26-Feb-99 PROGRESS ***, 81 unordered
pieces. GB_HTG1: CEY70C5 224525 Z98878 Caenorhabditis elegans
chromosome V clone Y70C5, *** SEQUENCING Caenorhabditis elegans
36,021 28-Aug-97 IN PROGRESS ***, in unordered pieces. rxa02007 756
GB_BA2: CGL012293 2952 AJ012293 Corynebacterium glutamicum ilvD
gene. Corynebacterium 100 01-OCT-1999 glutamicum GB_PR4: AC006285
150172 AC006285 Homo sapiens, complete sequence. Homo sapiens 38,74
15-Nov-99 GB_PR4: AC006285 150172 AC006285 Homo sapiens, complete
sequence. Homo sapiens 38,701 15-Nov-99 rxa02009 223 GB_PR4:
AC004926 153556 AC004926 Homo sapiens PAC clone DJ0910H09 from
7q21.1-q21.2, complete sequence. Homo sapiens 38,462 17-Feb-99
GB_PR2: AP000053 100000 AP000053 Homo sapiens genomic DNA,
chromosome 21q22.1, segment 24/28, complete Homo sapiens 37,674
20-Nov-99 sequence. GB_PR2: AP000121 100000 AP000121 Homo sapiens
genomic DNA of 21q22.1, GART and AML related, Homo sapiens 37,674
25-Sep-99 SLC5A3-f4A4 region, segment 4/8, complete sequence.
rxa02013 649 GB_BA1: MTCI237 27030 Z94752 Mycobacterium
tuberculosis H37Rv complete genome; segment 46/162. Mycobacterium
39,308 17-Jun-98 tuberculosis GB_HTG4: AC010885 201581 AC010885
Homo sapiens chromosome unknown Homo sapiens 37,206 29-OCT-1999
clone NH0368K23, WORKING DRAFT SEQUENCE, in unordered pieces.
GB_HTG4: AC010885 201581 AC010885 Homo sapiens chromosome unknown
clone NH0368K23, Homo sapiens 37,208 29-OCT-1999 WORKING DRAFT
SEQUENCE, In unordered pieces. rxa02014 630 GB_HTG3: AC010769
119431 AC010769 Homo sapiens chromosome 15 clone 28_B_17 map 15,
Homo sapiens 33,816 22-Sep-99 LOW-PASS SEQUENCE SAMPLING. GB_HTG3:
AC010769 119431 AC010769 Homo sapiens chromosome 15 clone 28_B_17
map 15, Homo sapiens 33,816 22-Sep-99
LOW-PASS SEQUENCE SAMPLING. GB_EST34: AI783738 320 AI783738
tu45b07.x1 NCI_CGAP_Pr28 Homo sapiens cDNA clone Homo sapiens
37,855 1-Jul-99 IMAGE: 2253973 3', mRNA sequence. rxa02019 524
GB_EST15: AA473289 318 AA473289 vd44g09.r1 Barstead MPLRB1 Mus
musculus cDNA Mus musculus 38,153 18-Jun-97 clone IMAGE: 803488 5',
mRNA sequence. GB_HTG1: CEY102A5_3 110000 Z99711 Caenorhabditis
elegans chromosome V clone Y102A5, Caenorhabditis elegans 38,867
9-Jun-98 *** SEQUENCING IN PROGRESS ***, in unordered pieces.
GB_HTG1: CEY102A5_3 110000 Z99711 Caenorhabditis elegans chromosome
V clone Y102A5, *** SEQUENCING Caenorhabditis elegans 38,867
9-Jun-98 IN PROGRESS ***, in unordered pieces. rxa02021 1071
GB_BA1: CGDNAAROP 2612 X85965 C. glutamicum ORF3 and aroP gene.
Corynebacterium 99,905 30-Nov-97 glutamicum GB_BA1: CGDAPE 1966
X81379 C. glutamicum dapE gene and orf2. Corynebacterium 36,406
8-Aug-95 glutamicum GB_BA1: SCI7 34893 AL096743 Streptomyces
coelicolor cosmid 17. Streptomyces coelicolor 36,782 1-Jul-99
rxa02023 891 GB_BA1: CGDAPE 1966 X81379 C. glutamicum dapE gene and
orf2. Corynebacterium 99,864 8-Aug-95 glutamicum GB_PR3: AC004067
161326 AC004067 Homo sapiens chromosome 4 clone B366O24 map 4q25,
complete sequence. Homo sapiens 39,651 8-Nov-98 GB_HTG3: AC009725
145005 AC009725 Mus musculus chromosome 6 clone 388_N_17 map 6, Mus
musculus 38,215 01-OCT-1999 *** SEQUENCING IN PROGRESS ***, 2
ordered pieces. rxa02032 693 GB_PR4: AC006961 171419 AC006961 Homo
sapiens chromosome 18, clone RP11-31P16, complete sequence. Homo
sapiens 37,703 19-Nov-99 GB_PR4: AC006961 171419 AC006961 Homo
sapiens chromosome 18, clone RP11-31P16, complete sequence. Homo
sapiens 40,839 19-Nov-99 rxa02036 504 GB_PR2: HSDJ799G3 127639
AL078624 Human DNA sequence from clone RP4-799G3 on Homo sapiens
35,657 22-Nov-99 chromosome 1q42.11-42.3, complete sequence.
GB_BA1: AOPCZA361 37941 AJ223998 Amycolatopsis orientalis cosmid
PCZA361. Amycolatopsis orientalis 46,341 29-MAR-1999 GB_PL1:
ATDNADAL1 8747 Y14851 Arabidopsis thaliana dal1 gene. Arabidopsis
thaliana 35,223 23-Sep-97 rxa02039 863 GB_PR3: AC005609 157970
AC005609 Homo sapiens chromosome 5, BAC clone 203o13 (LBNL H155),
complete sequence. Homo sapiens 37,176 4-Sep-98 GB_HTG3: AC008468
245016 AC008468 Homo sapiens chromosome 5 clone CIT-HSPC_365B8,
Homo sapiens 36,842 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 14
unordered pieces. GB_HTG3: AC008468 245016 AC008468 Homo sapiens
chromosome 5 clone CIT-HSPC_365B8, Homo sapiens 36,842 3-Aug-99 ***
SEQUENCING IN PROGRESS ***, 14 unordered pieces. rxa02040 551
GB_HTG3: AC009303 198549 AC009303 Homo sapiens clone NH0098C01, ***
SEQUENCING IN Homo sapiens 35,424 13-Aug-99 PROGRESS ***, 2
unordered pieces. GB_HTG3: AC009303 198549 AC009303 Homo sapiens
clone NH0098C01, *** SEQUENCING IN Homo sapiens 35,424 13-Aug-99
PROGRESS ***, 2 unordered pieces. GB_HTG3: AC009303 198549 AC009303
Homo sapiens clone NH0098C01, *** SEQUENCING IN Homo sapiens 32,597
13-Aug-99 PROGRESS ***, 2 unordered pieces. rxa02045 384 GB_EST3:
R23812 459 R23812 yh34g05.r1 Soares placenta Nb2HP Homo sapiens
cDNA clone Homo sapiens 47,273 20-Apr-95 IMAGE: 131672 5', mRNA
sequence. GB_EST19: AA778733 611 AA778733 af88d02.s1
Soares_testis_NHT Homo sapiens Homo sapiens 38,806 5-Feb-98 cDNA
clone 1049091 3', mRNA sequence. GB_PR2: HSU59185 2529 U59185 Human
putative monocarboxylate transporter (MCT) mRNA, complete cds. Homo
sapiens 43,164 03-OCT-1997 rxa02046 540 GB_HTG3: AC005507 196595
AC005507 Plasmodium falciparum chromosome 12 clone 3D7, Plasmodium
falciparum 37,218 23-Sep-99 *** SEQUENCING IN PROGRESS ***, 3
unordered pieces. GB_HTG3: AC005507 196595 AC005507 Plasmodium
falciparum chromosome 12 clone 3D7, Plasmodium falciparum 37,218
23-Sep-99 *** SEQUENCING IN PROGRESS ***, 3 unordered pieces.
GB_EST1: T09984 330 T09984 0540m7 gmbPfHB3.1, G. Roman Reddy
Plasmodium falciparum Plasmodium falciparum 32,121 29-Nov-93
genomic clone 0540m, mRNA sequence. rxa02049 732 GB_PL1: ATHCOLR
1098 M37778 A. thaliana middle repetative sequence. Arabidopsis
thaliana 33,755 27-Apr-93 GB_PL2: ATAC006954 87035 AC006954
Arabidopsis thaliana chromosome II BAC F25P17 Arabidopsis thaliana
33,755 7-Apr-99 genomic sequence, complete sequence. GB_EST33:
AI779067 495 AI779067 EST259946 tomato susceptible, Cornell
Lycopersicon Lycopersicon esculentum 35,223 29-Jun-99 esculentum
cDNA clone cLES7C7, mRNA sequence. rxa02050 918 GB_HTG2: AC008307
91654 AC008307 Drosophila melanogaster chromosome 3 clone
Drosophila melanogaster 36,182 2-Aug-99 BACR03D22 (D709) RPCI-98
03.D.22 map 86F-87A strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 94 unordered pieces. GB_HTG2: AC008307 91654 AC008307
Drosophila melanogaster chromosome 3 clone BACR03D22 (D709) RPCI-98
03.D.22 Drosophila melanogaster 36,182 2-Aug-99 map 86F-87A strain
y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 94 unordered pieces.
GB_EST31: AU060923 663 AU060923 AU060923 Dictyostelium discoideum
SL (H. Urushihara) Dictyostelium discoideum 39,388 20-MAY-1999
Dictyostelium discoideum cDNA clone SLC248, mRNA sequence. rxa02051
621 GB_EST16: C43898 369 C43896 C43896 Yuji Kohara unpublished
cDNA: Caenorhabditis elegans 41,16 18-OCT-1999 Strain N2
hermaphrodite embryo Caenorhabditis elegans cDNA clone yk336c10 5',
mRNA sequence. GB_EST16: C40413 360 C40413 C40413 Yuji Kohara
unpublished cDNA: Caenorhabditis elegans 42,09 18-OCT-1999 Strain
N2 hermaphrodite embryo Caenorhabditis elegans cDNA clone yk230e7
5', mRNA sequence. GB_EST36: AV191515 360 AV191515 AV191515 Yuji
Kohara unpublished cDNA: Strain N2 Caenorhabditis elegans 40,833
22-Jul-99 hermaphrodite embryo Caenorhabditis elegans cDNA clone
yk594g6 5', mRNA sequence. rxa02053 702 GB_IN1: AF035264 6397
AF035264 Drosophila melanogaster POU domain Drosophila melanogaster
36,888 04-DEC-1997 protein (pdm-1) gene, promoter region and exon
1. GB_BA1: MTV036 24055 AL021931 Mycobacterium tuberculosis H37Rv
complete genome; segment 19/162. Mycobacterium 37,647 17-Jun-98
tuberculosis GB_EST30: AI658116 497 AI658116 fc22e07.y1 Zebrafish
WashU MPIMG EST Danio rerio Danio rerio 41,129 06-MAY-1999 cDNA 5'
similar to TR: Q15883 Q15883 X104.;, mRNA sequence. rxa02057 654
GB_PAT: E14601 4394 E14601 Brevibacterium lactofermentum gene for
alpha-ketoglutaric acid dehydrogenase. Corynebacterium 96,667
28-Jul-99 glutamicum GB_BA1: D84102 4394 D84102 Corynebacterium
glutamicum DNA for 2-oxoglutarate dehydrogenase, complete cds.
Corynebacterium 96,667 6-Feb-99 glutamicum GB_PAT: E14601 4394
E14601 Brevibacterium lactofermentum gene for alpha-ketoglutaric
acid dehydrogenase. Corynebacterium 38,199 28-Jul-99 glutamicum
rxa02058 675 GB_GSS9: AQ129748 432 AQ129748 HS_2254_B1_H03_MF CIT
Approved Human Homo sapiens 40 23-Sep-98 Genomic Sperm Library D
Homo sapiens genomic clone Plate = 2254 Col = 5 Row = P, genomic
survey sequence. GB_PL2: T15B16 90596 AF104919 Arabidopsis thaliana
BAC T15B16. Arabidopsis thaliana 35,338 11-Nov-98 GB_PL2: AC007138
120185 AC007138 Arabidopsis thaliana BAC T7B11 from chromosome IV
near 10 cM, complete Arabidopsis thaliana 39,426 1-Apr-99 sequence.
rxa02059 618 GB_HTG3: AC008672 131573 AC008672 Homo sapiens
chromosome 5 clone CIT978SKB_3B12, Homo sapiens 40,871 3-Aug-99 ***
SEQUENCING IN PROGRESS ***, 71 unordered pieces. GB_HTG3: AC008672
131573 AC008672 Homo sapiens chromosome 5 clone CIT978SKB_3B12,
Homo sapiens 40,871 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 71
unordered pieces. GB_IN1: DDU06228 2695 U06228 Dictyostelium
discoideum CRAC (dagA) gene, complete cds. Dictyostelium discoideum
36,513 1-Feb-95 rxa02066 615 GB_PR2: CNS01DRA 198444 AL110505 Human
chromosome 14 DNA sequence *** IN PROGRESS Homo sapiens 36,903
11-Nov-99 *** BAC R-816J8 of RPCI-11 library from chromosome 14 of
Homo sapiens (Human), complete sequence. GB_PR2: HS230G1 125515
Z84468 Homo sapiens DNA sequence from PAC 230G1 on chromosome Homo
sapiens 41,751 23-Nov-99 Xp11.3. Contains EST, STS and GSS,
complete sequence. GB_PR2: CNS01DRA 198444 AL110505 Human
chromosome 14 DNA sequence *** IN PROGRESS *** BAC R-816J8 of Homo
sapiens 36,589 11-Nov-99 RPCI-11 library from chromosome 14 of Homo
sapiens (Human), complete sequence. rxa02067 579 GB_HTG3: AC009543
159209 AC009543 Homo sapiens chromosome 11 clone 63_H_13 map 11,
*** Homo sapiens 35,366 07-OCT-1999 SEQUENCING IN PROGRESS ***, 12
unordered pieces. GB_HTG3: AC009543 159209 AC009543 Homo sapiens
chromosome 11 clone 63_H_13 map 11, *** Homo sapiens 35,366
07-OCT-1999 SEQUENCING IN PROGRESS ***, 12 unordered pieces.
GB_PR2: HS230G1 125515 Z84486 Homo sapiens DNA sequence from PAC
230G1 on chromosome Homo sapiens 36,348 23-Nov-99 Xp11.3. Contains
EST, STS and GSS, complete sequence. rxa02069 702 GB_BA1: MTCI61
13540 Z98260 Mycobacterium tuberculosis H37Rv complete genome;
segment 53/162. Mycobacterium 36,642 17-Jun-98 tuberculosis GB_BA1:
MTCI61 13540 Z98260 Mycobacterium tuberculosis H37Rv complete
genome: segment 53/162. Mycobacterium 39,474 17-Jun-98 tuberculosis
rxa02070 1245 GB_BA2: AE001112 14704 AE001112 Archaeoglobus
fulgidus section 167 of 172 of the complete genome. Archaeoglobus
fulgidus 39,352 15-DEC-1997 GB_PR3: HSDJ47M23 129320 AL096816 Human
DNA sequence *** SEQUENCING IN PROGRESS Homo sapiens 40,413
23-Nov-99 *** from clone dJ47M23, complete sequence. GB_HTG3:
AC009139 152666 AC009139 Homo sapiens chromosome 16 clone
RPCI-11_538|12, Homo sapiens 35,275 3-Aug-99 *** SEQUENCING IN
PROGRESS ***, 27 unordered pieces. rxa02076 657 GB_EST34: AI789138
594 AI789138 uk51e02.y1 Sugano mouse kidney mkia Mus musculus cDNA
Mus musculus 43,041 2-Jul-99 clone IMAGE: 1972538 5' similar to WP:
R10H10.7 CE06298 TYROSINE-PROTEIN KINASE LIKE;, mRNA sequence.
GB_GSS1: FR0013995 552 AL005239 F. rubripes GSS sequence, clone
137O18aC6, genomic survey sequence. Fugu rubripes 37,079 18-Sep-97
GB_GSS3: B27548 642 B27548 F19J9TFB IGF Arabidopsis thaliana
genomic clone F19J9, genomic survey sequence. Arabidopsis thaliana
37,056 13-OCT-1997 rxa02080 930 GB_GSS15: AQ652136 411 AQ652136
Sheared DNA-7M23.TR Sheared DNA Trypanosoma brucei Trypanosoma
brucel 39,259 22-Jun-99 genomic clone Sheared DNA-7M23, genomic
survey sequence. GB_GSS15: AQ652498 450 AQ652498 Sheared
DNA-22K16.TR Sheared DNA Trypanosoma brucel Trypanosoma brucei
39,597 22-Jun-99 genomic clone Sheared DNA-22K16, genomic survey
sequence. GB_HTG3: AC009683 171597 AC009683 Homo sapiens chromosome
8 clone 76_N_5 map 8, Homo sapiens 37,053 29-Sep-99 *** SEQUENCING
IN PROGRESS ***, 10 unordered pieces. rxa02081 1752 GB_OV: BSU43200
2070 U43200 Boreogadus saida antifreeze glycopeptide Boreogadus
saida 37,016 12-MAY-1997 AFGP polyprotein precursor gene, complete
cds. GB_BA2: AE001615 12401 AE001615 Chlamydia pneumoniae section
31 of 103 of the complete genome. Chlamydophila pneumoniae 36,385
08-MAR-1999 GB_OV: BSU43200 2070 U43200 Boreogadus saida antifreeze
glycopeptide Boreogadus saida 37,672 12-MAY-1997 AFGP polyprotein
precursor gene, complete cds. rxa02084 468 GB_PR4: AC007382 80547
AC007382 Homo sapiens Homo sapiens 41,138 8-Sep-99 clone NH0288C18,
complete sequence. GB_GSS4: AQ731530 508 AQ731530
HS_5543_A2_A05_T7A RPCI-11 Human Male Homo sapiens 36,245 15-Jul-99
BAC Library Homo sapiens genomic clone Plate = 1119 Col = 10 Row =
A, genomic survey sequence. GB_PR4: AC007382 80547 AC007382 Homo
sapiens clone NH0288C18, complete sequence. Homo sapiens 35,398
8-Sep-99 rxa02089 594 GB_PR2: AP000031 149298 AP000031 Homo sapiens
genomic DNA, chromosome 21q22.1, segment 2/28, complete Homo
sapiens 38,699 20-Nov-99 sequence. GB_PR2: AP000135 111894 AP000135
Homo sapiens genomic DNA of 21q22.1, GART and AML, Homo sapiens
38,699 25-Sep-99 f43D11-119B8 region, segment 10/10, complete
sequence. GB_PR2: AP000213 100000 AP000213 Homo sapiens genomic
DNA, chromosome 21q22.1, Homo sapiens 38,699 20-Nov-99 D21S226-AML
region, clone f43D11-119B8, segment 11/12, complete sequence.
rxa02090 924 GB_PL2: ATAC006841 123183 AC006841 Arabidopsis
thaliana chromosome II BAC F3K23 Arabidopsis thaliana 39,826
6-Apr-99 genomic sequence, complete sequence. GB_PL1: SCXV55KB
54719 Z70678 S. cerevisiae chromosome XV DNA, 54.7 kb region.
Saccharomyces cerevisiae 37,817 16-MAY-1997 GB_PR1: D87675 301692
D87675 Homo sapiens DNA for amyloid precursor protein, complete
cds. Homo sapiens 39,14 22-Sep-97 rxa02091 774 GB_BA2: AF031929
2675 AF031929 Lactobacillus helveticus cochaperonin GroES and
chaperonin GroEL Lactobacillus helveticus 35,509 8-Aug-98 genes,
complete cds; and DNA mismatch repair enzyme (hexA) gene, partial
cds. GB_BA1: CGU43536 3464 U43536 Corynebacterium glutamicum heat
shock, ATP-binding Corynebacterium 39,124 13-MAR-1997 protein
(clpB) gene, complete cds. glutamicum GB_BA1: RCFBC 3874 X03476
Rhodopseudomonas sphaeroides fbc operon (fbcF, fbcB, fbcC genes).
Rhodobacter sphaeroides 36,478 10-Feb-99 rxa02094 840 GB_RO:
MMHC188A7 120990 AF109719 Mus musculus casein kinase 2 beta subunit
(gMCK2) gene, Mus musculus 38,118 25-OCT-1999 partial cds; BAT4,
NG20 (NG20), BAT3, BAT2, AIF-1, B144, lymphotoxin beta, TNF, and
TNF beta genes, complete cds; IKBL gene, partial cds; and unknown
gene. GB_EST10: AA168948 549 AA168948 ms39c08.r1 Life Tech mouse
embryo 13 5dpc 10666014 Mus musculus 40,789 19-DEC-1996 Mus
musculus cDNA clone IMAGE: 613934 5' similar to gb: U15980 Mus
musculus (MOUSE);, mRNA sequence.
GB_EST24: AI101223 348 AI101223 EST210512 Normalized rat brain,
Bento Soares Rattus sp. Rattus sp. 40,634 31-Jan-99 cDNA clone
RBRBK04 3' end, mRNA sequence. rxa02097 3495 GB_BA2: RMU31512 1974
U31512 Rhizobium meliloti RmDEGP (degP) gene, complete cds.
Sinorhizobium meliloti 39,159 05-MAR-1996 GB_EST15: AA502050 346
AA502050 ng57c04.s1 NCI_CGAP_Lip2 Homo sapiens cDNA Homo sapiens
40,751 18-Aug-97 clone IMAGE: 938886 similar to contains Alu
repetitive element;, mRNA sequence. GB_EST16: AA589883 400 AA589883
vl80h08.r1 Stratagene mouse diaphragm (#937303) Mus musculus 35,427
16-Sep-97 Mus musculus cDNA clone IMAGE: 987039 5' similar to gb:
M75716 Mus musculus alpha-1 protease inhibitor 2 (MOUSE);, mRNA
sequence. rxa02102 1281 GB_IN2: AF135118 10830 AF135118 Drosophila
melanogaster laminin alpha1,2 (wing blister) mRNA, complete cds.
Drosophila melanogaster 36,926 23-MAY-1999 GB_IN1: AC002516 48158
AC002516 Drosophila melanogaster (P1 DS01068 (D37)) DNA sequence,
complete sequence. Drosophila melanogaster 37,838 28-Aug-97
GB_GSS3: B09866 1194 B09866 T16G20-Sp6 TAMU Arabidopsis thaliana
genomic clone Arabidopsis thaliana 35,332 14-MAY-1997 T16G20,
genomic survey sequence. rxa02103 519 GB_GSS3: B09866 1194 B09866
T16G20-Sp6 TAMU Arabidopsis thaliana genomic Arabidopsis thaliana
36,31 14-MAY-1997 clone T16G20, genomic survey sequence. GB_EST34:
AV165661 290 AV165661 AV165661 Mus musculus head C57BL/6J 13-day
embryo Mus musculus Mus musculus 37,716 6-Jul-99 cDNA clone
3110038F04, mRNA sequence. GB_RO: AC002121 84056 AC002121 Genomic
sequence from Mouse 11, complete sequence. Mus musculus 39,096
10-Jul-97 rxa02104 1245 GB_BA2: ECOUW67_0 110000 U18997 Escherichia
coli K-12 chromosomal region from 67.4 to 76.0 minutes. Escherichia
coli 39,024 22-Dec-94 GB_BA2: AE000394 12221 AE000394 Escherichia
coli K-12 MG1655 section 284 of 400 of the complete genome.
Escherichia coli 39,024 12-Nov-98 GB_BA1: ECORNPBW 4434 D90212 E.
coli rnpB gene and ORFs. Escherichia coli 45,255 7-Feb-99 rxa02107
rxa02108 732 GB_BA1: D90912 128598 D90912 Synechocystis sp. PCC6803
complete genome, 14/27, 1719644-1848241. Synechocystis sp. 38,095
7-Feb-99 GB_GSS13: AQ498890 431 AQ498890 HS_5154_A1_E06_SP6E
RPCI-11 Human Male Homo sapiens 37,15 28-Apr-99 BAC Library Homo
sapiens genomic clone Plate = 730 Col = 11 Row = I, genomic survey
sequence. GB_BA1: D90912 128598 D90912 Synechocystis sp. PCC6803
complete genome, 14/27, 1719644-1848241. Synechocystis sp. 38,781
7-Feb-99 rxa02109 1044 GB_IN2: AC001658 91019 AC001658 Drosophila
melanogaster DNA sequence (P1 DS00913 (D24)), complete sequence.
Drosophila melanogaster 35,687 17-Jul-98 GB_EST19: AA802304 581
AA802304 GM04170.5prime GM Drosophila melanogaster Drosophila
melanogaster 40,451 25-Nov-98 ovary BlueScript Drosophila
melanogaster cDNA clone GM04170 5prime, mRNA sequence. GB_EST35:
AI822653 733 AI822653 L0-1173T3 Ice plant Lambda Uni-Zap XR
expression library, 0 hours NaCl treatment Mesembryanthemum 36,957
12-Jul-99 Mesembryanthemum crystallinum cDNA clone L0-1173
crystallinum 5' similar to Profilin 1 (AF092547) [Ricinus communis,
mRNA sequence. rxa02114 509 GB_BA1: SMU94899 2379 U94899
Sinorhizobium meliloti dissimilatory nitrous oxide reduction
proteins Sinorhizobium meliloti 42,744 6-Sep-97 NosY, NosL and NosX
genes, complete cds. GB_BA1: SMU94899 2379 U94899 Sinorhizobium
meliloti dissimilatory nitrous oxide reduction Sinorhizobium
meliloti 39,486 6-Sep-97 proteins NosY, NosL and NosX genes,
complete cds. rxa02117 597 GB_BA2: AF094575 18754 AF094575
Streptococcus pneumoniae serotype 19A DexB (dexB) gene, partial
sequence; capsular Streptococcus pneumoniae 40,48 9-Sep-99
polysaccharide biosynthesis operon, complete sequence; and
oligopeptide permease AliA (aliA) gene, partial cds. GB_BA2:
AF105113 5832 AF105113 Streptococcus pneumoniae type 19A putative
oligosaccharide repeat unit transporter Streptococcus pneumoniae
40,652 9-Sep-99 (cps19AJ) gene, partial cds; UDP-N-acetyl
glucosamine-2-epimerase (cps19AK), glucose-1-phosphate thymidylyl
transferase (cps19AL), dTDP-4-keto-6- deoxyglucose-3,5-epimerase
(cps19AM), dTDP-glucose-4,6 dehydratase (cps19AN), and
dTDP-L-rhamnose synthase (cps19AO) genes, complete cds; and AliA
(aliA) gene, partial cds. GB_EST9: AA073381 429 AA073381 mm93a12.r1
Stratagene mouse heart (#937316) Mus musculus cDNA clone Mus
musculus 46,341 15-Feb-97 IMAGE: 535966 5' similar to gb: X03765
Mouse mRNA for cytoplasmatic beta-actin (MOUSE):, mRNA sequence.
rxa02121 828 GB_PR4: AC004874 95983 AC004874 Homo sapiens PAC clone
DJ0744D13 from 7q11, complete sequence. Homo sapiens 40,791
21-Nov-98 GB_EST14: AA418305 440 AA418305 zv96g05.s1
Soares_NhHMPu_S1 Homo sapiens cDNA clone Homo sapiens 40,093
16-OCT-1997 IMAGE: 767672 3', mRNA sequence. GB_BA2: U32763 12021
U32763 Haemophilus influenzae Rd section 78 of 163 of the complete
genome. Haemophilus influenzae Rd 37,715 29-MAY-1998 rxa02123 1494
GB_BA1: MTCY10D7 39800 Z79700 Mycobacterium tuberculosis H37Rv
complete genome; segment 44/162. Mycobacterium 62,083 17-Jun-98
tuberculosis GB_BA1: MTCY10D7 39800 Z79700 Mycobacterium
tuberculosis H37Rv complete genome; segment 44/162. Mycobacterium
38,462 17-Jun-98 tuberculosis GB_GSS15: AQ639831 649 AQ639831
927P1-20A2.TV 927P1 Trypanosoma brucei Trypanosoma brucei 36,124
8-Jul-99 genomic clone 927P1-20A2, genomic survey sequence.
rxa02124 2079 GB_PR2: HS242N11 167514 AL023655 Human DNA sequence
from clone 242N11 on chromosome Homo sapiens 33,866 23-Nov-99
6p22.3-23. Contains ESTs, STSs, GSSs, genomic marker D6S285, and ca
and gaaa repeat polymorphisms, complete sequence. GB_PR2: HS242N11
167514 AL023655 Human DNA sequence from clone 242N11 on chromosome
6p22.3-23. Homo sapiens 36,342 23-Nov-99 Contains ESTs, STSs, GSSs,
genomic marker D6S285, and ca and gaaa repeat polymorphisms,
complete sequence. rxa02125 924 GB_HTG1: CEY116A8_4 110000 Z98858
Caenorhabditis elegans chromosome IV clone Y116A8, Caenorhabditis
elegans 36,615 23-Jan-98 *** SEQUENCING IN PROGRESS ***, in
unordered pieces. GB_IN1: CEY116A8B 29344 AL021469 Caenorhabditis
elegans cosmid Y116A8B, complete sequence. Caenorhabditis elegans
36,615 23-Nov-98 GB_HTG1: CEY116A8_4 110000 Z98858 Caenorhabditis
elegans chromosome IV clone Y116A8, Caenorhabditis elegans 36,615
23-Jan-98 *** SEQUENCING IN PROGRESS ***, in unordered pieces.
rxa02129 357 GB_HTG5: AC007809 141122 AC007809 Drosophila
melanogaster chromosome 3 clone BACR45M03 Drosophila melanogaster
37,255 16-Nov-99 (D718) RPCI-98 45.M.3 map 88C-88C strain y; cn bw
sp. *** SEQUENCING IN PROGRESS ***, 98 unordered pieces. GB_IN2:
CELT02C5 36267 U55374 Caenorhabditis elegans cosmid T02C5.
Caenorhabditis elegans 41,834 08-OCT-1999 GB_IN1: CEZC101 26147
Z93395 Caenorhabditis elegans cosmid ZC101, complete sequence.
Caenorhabditis elegans 38,873 23-Jul-99 rxa02132 rxa02137 921
GB_EST16: C48630 360 C48630 C48630 Yuji Kohara unpublished cDNA:
Strain N2 hermaphrodite Caenorhabditis elegans 39,326 18-OCT-1999
embryo Caenorhabditis elegans cDNA clone yk459c11 5', mRNA
sequence. GB_GSS12: AQ381854 597 AQ381854 RPCI11-137P5.TJ RPCI-11
Homo sapiens genomic Homo sapiens 37,879 21-MAY-1999 clone
RPCI-11-137P5, genomic survey sequence. GB_HTG3: AC010253 74835
AC010253 Homo sapiens chromosome 5 clone CIT-HSPC_432B14, ***
SEQUENCING IN Homo sapiens 35,082 15-Sep-99 PROGRESS ***, 34
unordered pieces. rxa02138 465 GB_BA1: SC6G10 36734 AL049497
Streptomyces coelicolor cosmid 6G10. Streptomyces coelicolor 40,047
24-MAR-1999 GB_BA1: MSGB1554CS 36548 L78814 Mycobacterium leprae
cosmid B1554 DNA sequence. Mycobacterium leprae 60,991 15-Jun-96
GB_BA1: MSGB1551CS 36548 L78813 Mycobacterium leprae cosmid B1551
DNA sequence. Mycobacterium leprae 60,991 15-Jun-96 rxa02141 531
GB_HTG2: AC003118 98940 AC003118 Homo sapiens chromosome 1, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 34,008 24-Nov-97 3
unordered pieces. GB_HTG2: AC003118 98940 AC003118 Homo sapiens
chromosome 1, *** SEQUENCING IN Homo sapiens 34,008 24-Nov-97
PROGRESS ***, 3 unordered pieces. GB_PR3: HS395P12 147724 AL022310
Human DNA sequence from clone 395P12 on chromosome 1q24-25.
Contains Homo sapiens 34,008 23-Nov-99 the TXGP1 gene for
tax-transcriptionally activated glycoprotein 1 (34 kD) (OX40
ligand, OX40L) and a GOT2 (Aspartate Aminotransferase,
mitochondrial precursor, EC 2.6.1.1, Transaminase A, Glutamate
Oxaloacetate Transaminase-2) pseudogene. Contains ESTs, STSs and
GSSs, complete sequence. rxa02146 750 GB_BA1: SC6G10 36734 AL049497
Streptomyces coelicolor cosmid 6G10. Streptomyces coelicolor 36,167
24-MAR-1999 GB_HTG6: AC008224 199774 AC008224 Drosophila
melanogaster chromosome 3 clone BACR29J02 (D817) Drosophila
melanogaster 36,437 24-Nov-99 RPCI-98 29.J.2 map 83D-83D strain y;
cn bw sp, *** SEQUENCING IN PROGRESS***, 37 unordered pieces.
GB_GSS12: AQ407179 476 AQ407179 HS_5088_A2_G01_T7A RPCI-11 Human
Male BAC Library Homo sapiens 37,143 17-MAR-1999 Homo sapiens
genomic clone Plate = 664 Col = 2 Row = M, genomic survey sequence.
rxa02151 1311 GB_PR3: AC000074 44450 AC000074 Homo sapiens
Chromosome 22q11.2 Cosmid Clone 20b In DGCR Homo sapiens 37,798
31-OCT-1998 Region, complete sequence. GB_PR2: HSAC002122 79931
AC002122 Human unknown clone GS293J04 from 5p15.2, complete
sequence. Homo sapiens 36,064 27-MAY-1997 GB_PR2: HSAC002122 79931
AC002122 Human unknown clone GS293J04 from 5p15.2, complete
sequence. Homo sapiens 35,051 27-MAY-1997 rxa02152 525 GB_PAT:
AR009990 2793 AR009990 Sequence 1 from patent U.S. Pat. No.
5756677. Unknown. 44,311 04-DEC-1998 GB_IN1: AF027735 3060 AF027735
Nephila clavipes minor ampullate silk protein MiSp1 mRNA, partial
cds. Nephila clavipes 44,311 23-Apr-98 GB_PAT: I95876 2793 I95876
Sequence 1 from patent U.S. Pat. No. 5733771. Unknown. 44,311
01-DEC-1998 rxa02163 876 GB_PR3: HSJ1175I6 96276 AL049538 Human DNA
sequence from clone 1175I6 on chromosome 20. Homo sapiens 36,385
23-Nov-99 Contains the gene for Ras inhibitor JC265 (Ras
association (RalGDS/AF-6) domain containing protein), ESTs, STSs,
GSSs and two putative CpG Islands, complete sequence. GB_GSS4:
AQ690740 975 AQ690740 nbxb0082N18f CUGI Rice BAC Library Oryza
sativa genomic Oryza sativa 39,474 1-Jul-99 clone nbxb0082N18f,
genomic survey sequence. GB_PH: SVVWBORF 6051 X72092 Streptomyces
venezuelae bacteriophage VWB orfs. Bacteriophage VWB 41,416
24-Aug-95 rxa02164 1698 GB_BA2: AF000579 8931 AF000579 Bordetelia
bronchiseptica LysR transcriptional Bordetella bronchiseptica
38,005 23-Feb-98 activator homolog (bbuR), urease accessory protein
D (ureD), urease structural subunit A (ureA), urease accessory
protein J (ureJ), urease structural subunits B (ureB) and C (ureC),
urease accessory proteins EF (ureEF) and G (ureG) genes, complete
cds. GB_PR3: HS431P23 147971 AL009178 Human DNA sequence from clone
431P23 on chromosome 6q27. Homo sapiens 35,604 23-Nov-99 Contains
the first coding exon of the MLLT4 gene for myeloid/lymphoid or
mixed-lineage leukemia (trithorax (Drosophila) homolog);
translocated to, 4 (AF-6, Afadin, MLLT-4, ALL-1 fusion partner),
and a Serine Palmitoyltransferase 2 (EC 2.3.1.50, Long Chain Base
Biosynthesis protein 2, LCB-2, SPT-2) pseudogene. Contains ESTs,
STas, GSSs, and a putative CpG island, complete sequence. GB_PR2:
AB016897 331211 AB016897 Homo sapiens genomic DNA, chromosome 6q27,
complete sequence. Homo sapiens 38,314 20-Nov-99 rxa02165 735
GB_IN2: AF079177 2159 AF079177 Theileria parva strain KNP2 p67
surface antigen (p67) gene, complete cds. Theileria parva 39,207
09-MAR-1999 GB_IN2: AF079176 2285 AF079176 Theileria parva strain
Hluhluwe3 p67 surface antigen (p67) gene, complete cds. Theileria
parva 39,049 09-MAR-1999 GB_EST27: AI397572 482 AI397572 NCSC5G2T3
Subtracted Conidial Neurospora Neurospora crassa 38,936 8-Feb-99
crassa cDNA clone SC5G2 5', mRNA sequence. rxa02166 300 GB_BA1:
MLCB1351 38936 Z95117 Mycobacterium leprae cosmid B1351.
Mycobacterium leprae 37,627 24-Jun-97 GB_BA1: MLCB1351 38936 Z95117
Mycobacterium leprae cosmid B1351. Mycobacterium leprae 40,741
24-Jun-97 rxa02168 2937 GB_BA1: MAFASGEN 10520 X87822 B.
ammoniagenes FAS gene. Corynebacterium 61,515 03-OCT-1996
ammoniagenes GB_BA1: MLCL458 43839 AL049478 Mycobacterium leprae
cosmid L458. Mycobacterium leprae 50,292 27-Aug-99 GB_PR3: HSL19H1
40145 Z68164 Human DNA sequence from cosmid L19H1, Huntington's
Disease Homo sapiens 37,621 23-Nov-99 Region, chromosome 4p16.3,
containing multiple EST matches. rxa02169 969 GB_RO: MMA3CA212 4784
X94406 Mus musculus partial b3 gene for alpha3 subunit of L-type
Ca2+ channel, exons 2-13. Mus musculus 37,62 24-Nov-99 GB_RO:
RATCACH3B 2525 M88751 Rat calcium channel beta subunit-III mRNA,
complete cds. Rattus norvegicus 36,345 27-MAY-1994 GB_RO: MMU20372
2469 U20372 Mus musculus voltage-dependent calcium channel beta-3
Mus musculus 36,865 02-MAR-1996 subunit (CCHB3) mRNA, complete cds.
rxa02170 897 GB_HTG6: AC005497 212097 AC005497 Homo sapiens
chromosome 17 clone RP11-952N18 map 17, Homo sapiens 36,101
20-Nov-99 *** SEQUENCING IN PROGRESS ***, 2 ordered pieces.
GB_HTG6: AC005497 212097 AC005497 Homo sapiens chromosome 17 clone
RP11-952N18 map 17, *** SEQUENCING Homo sapiens 37,57 20-Nov-99 IN
PROGRESS ***, 2 ordered pieces. GB_PR2: AP000104 100000 AP000104
Homo sapiens genomic DNA of 21q22.1, GART and AML related,
Q78C10-149C3 Homo sapiens 34,871 25-Sep-99
region, segment 7/20, complete sequence. rxa02172 462 GB_EST24:
AI170522 367 AI170522 EST216450 Normalized rat lung, Bento Soares
Rattus sp. cDNA Rattus sp. 38,904 20-Jan-99 clone RLUCO75 3' end,
mRNA sequence. GB_GSS13: AQ430048 538 AQ430048 HS_5061_B2_G09_T7A
RPCI-11 Human Male BAC Library Homo sapiens 37,143 31-MAR-1999 Homo
sapiens genomic clone Plate = 637 Col = 18 Row = N, genomic survey
sequence. GB_GSS4: AQ701704 589 AQ701704 HS_2130 A1_E03_MR CIT
Approved Human Genomic Sperm Library D Homo Homo sapiens 35,28
7-Jul-99 sapiens genomic clone Plate = 2130 Col = 5 Row = I,
genomic survey sequence. rxa02177 1056 GB_HTG4: AC009403 198495
AC009403 Homo sapiens clone DJ1015O24, *** SEQUENCING Homo sapiens
37,154 28-OCT-1999 IN PROGRESS ***, 3 unordered pieces. GB_HTG4:
AC009403 198495 AC009403 Homo sapiens clone DJ1015O24, ***
SEQUENCING Homo sapiens 37,154 28-OCT-1999 IN PROGRESS ***, 3
unordered pieces. GB_PR2: AP000094 100000 AP000094 Homo sapiens
genomic DNA of 21q22.1, GART and AML related, Homo sapiens 38,536
25-Sep-99 B335D16-P10G11 region, segment 4/7, complete sequence.
rxa02178 rxa02180 1581 GB_BA1: SC6C5 18160 AL034492 Streptomyces
coelicolor cosmid 6C5. Streptomyces coelicolor 53,635 14-DEC-1998
GB_HTG4: AC011121 172050 AC011121 Homo sapiens chromosome 11 clone
364_C_06 map 11, *** Homo sapiens 37,17 14-OCT-1999 SEQUENCING IN
PROGRESS ***, 9 ordered pieces. GB_HTG4: AC011121 172050 AC011121
Homo sapiens chromosome 11 clone 364_C_06 map 11, *** SEQUENCING
Homo sapiens 37,17 14-OCT-1999 IN PROGRESS ***, 9 ordered pieces.
rxa02181 801 GB_PL1: STU76701 3049 U76701 Solanum tuberosum NADH
nitrate reductase (StNR2) mRNA, complete cds. Solanum tuberosum
38,846 18-Nov-96 GB_EST36: AI896605 633 AI896605 EST266048 tomato
callus, TAMU Lycopersicon esculentum Lycopersicon esculentum 39,671
27-Jul-99 cDNA clone cLEC16C12, mRNA sequence. GB_EST38: AW035744
620 AW035744 EST281898 tomato callus, TAMU Lycopersicon
Lycopersicon esculentum 40,555 15-Sep-99 esculentum cDNA clone
cLEC36M13, mRNA sequence. rxa02183 rxa02185 702 GB_BA1: MTV043
68848 AL022004 Mycobacterium tuberculosis H37Rv complete genome;
segment 40/162. Mycobacterium 38,793 24-Jun-99 tuberculosis GB_BA1:
MSGB1935CS 40085 L04666 M. leprae genomic sequence, cosmid b1935.
Mycobacterium leprae 38,067 14-Jun-96 GB_BA1: MLCB57 38029 Z99494
Mycobacterium leprae cosmid B57. Mycobacterium leprae 38,067
10-Feb-99 rxa02186 321 GB_BA2: CNSPAX03 307120 AJ248285 Pyrococcus
abyssi complete genome; segment 3/6. Pyrococcus abyssi 35,873
9-Sep-99 GB_HTG3: AC010677 116108 AC010677 Homo sapiens clone
MS2304L04, *** SEQUENCING IN Homo sapiens 39,145 04-OCT-1999
PROGRESS ***, 4 unordered pieces. GB_HTG3: AC010677 116108 AC010677
Homo sapiens clone MS2304L04, *** SEQUENCING Homo sapiens 39,145
04-OCT-1999 IN PROGRESS ***, 4 unordered pieces. rxa02187 2322
GB_EST33: AI779784 362 AI779784 EST260663 tomato susceptible,
Cornell Lycopersicon esculentum Lycopersicon esculentum 41,011
29-Jun-99 cDNA clone cLES9K1, mRNA sequence. GB_EST33: AI779784 362
AI779784 EST260663 tomato susceptible, Cornell Lycopersicon
Lycopersicon esculentum 41,011 29-Jun-99 esculentum cDNA clone
cLES9K1, mRNA sequence. rxa02199 693 GB_PR3: AC005274 205150
AC005274 Homo sapiens chromosome 17, clone hRPK.1090_M_7, complete
sequence. Homo sapiens 36,337 29-Jul-98 GB_HTG2: AC007732 110348
AC007732 Homo sapiens chromosome 17 clone hRPC.1030_A_12 Homo
sapiens 35,924 5-Jun-99 map 17, *** SEQUENCING IN PROGRESS ***, 7
unordered pieces. GB_IN1: DMU11052 4871 U11052 Drosophila
melanogaster peroxidasin precursor mRNA, complete cds. Drosophila
melanogaster 39,873 26-Jan-95 rxa02203 501 GB_EST17: AA642571 323
AA642571 nq73c08.s1 NCI_CGAP_Pr22 Homo sapiens cDNA clone IMAGE:
1157966 Homo sapiens 49,485 27-OCT-1997 3' similar to TR: G9372
G9372 UBIQUITIN;, mRNA sequence. GB_EST27: AI425489 312 AI425489
my32e11.y1 Barstead mouse pooled organs MPLRB4 Mus musculus cDNA
Mus musculus 40,514 09-MAR-1999 clone IMAGE: 697580 5', mRNA
sequence. GB_EST23: AI154481 308 AI154481 ua03h07.r1 Soares 2NbMT
Mus musculus cDNA clone Mus musculus 42,748 30-Sep-98 IMAGE:
1345693 5', mRNA sequence. rxa02206 1059 GB_PR2: AP000269 70932
AP000269 Homo sapiens genomic DNA, chromosome 21q22.1, D21S226-AML
region, Homo sapiens 39,306 20-Nov-99 clone: T293, complete
sequence. GB_PL1: D32140 1360 D32140 Cyanidioschyzon merolae DNA
for actin, complete cds. Cyanidioschyzon merolae 37,331 7-Feb-99
GB_PR2: AP000269 70932 AP000269 Homo sapiens genomic DNA,
chromosome 21q22.1, D21S226-AML Homo sapiens 35,481 20-Nov-99
region, clone: T293, complete sequence. rxa02207 898 GB_EST21:
AA982901 442 AA982901 vx59f07.r1 Stratagene mouse macrophage
(#937306) Mus musculus 42,141 27-MAY-1998 Mus musculus cDNA clone
IMAGE: 1279525 5' similar to gb:
X59543_ma1RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 CHAIN (HUMAN);
gb: K02927 Mouse ribonucleotide reductase subunit M1 mRNA, complete
(MOUSE);, mRNA sequence. GB_EST8: W85369 558 W85369 mf48h04.r1
Soares mouse embryo NbME13.5 14.5 Mus musculus cDNA Mus musculus
39,964 12-Sep-96 clone IMAGE: 408343 5' similar to gb: K02927 Mouse
ribonucleotide reductase subunit M1 mRNA, complete (MOUSE);, mRNA
sequence. GB_PAT: E14824 2379 E14824 cDNA encoding M1 subunit of
human ribonucleotide reductase. Homo sapiens 36,812 28-Jul-99
rxa02211 rxa02212 621 GB_HTG3: AC009518 241128 AC009518 Homo
sapiens chromosome 7, *** SEQUENCING IN Homo sapiens 36,542
1-Sep-99 PROGRESS ***, 68 unordered pieces. GB_HTG3: AC009518
241128 AC009518 Homo sapiens chromosome 7, *** SEQUENCING IN Homo
sapiens 36,542 1-Sep-99 PROGRESS ***, 68 unordered pieces. GB_HTG3:
AC009518 241128 AC009518 Homo sapiens chromosome 7, *** SEQUENCING
Homo sapiens 41,362 1-Sep-99 IN PROGRESS ***, 68 unordered pieces.
rxa02216 329 GB_HTG2: AC007641 102402 AC007641 Mus musculus
chromosome 10 clone 644_M_8 map Mus musculus 31,307 22-MAY-1999 10,
*** SEQUENCING IN PROGRESS ***, 7 unordered pieces. GB_HTG2:
AC007641 102402 AC007641 Mus musculus chromosome 10 clone 644_M_8
map 10, *** SEQUENCING Mus musculus 31,307 22-MAY-1999 IN PROGRESS
***, 7 unordered pieces. GB_HTG2: AC007641 102402 AC007641 Mus
musculus chromosome 10 clone 644_M_8 map 10, *** SEQUENCING Mus
musculus 32,198 22-MAY-1999 IN PROGRESS ***, 7 unordered pieces.
rxa02217 786 GB_RO: RNU91516 1540 U91516 Rattus norvegicus oxytocin
receptor (OTR) gene, promoter region. Rattus norvegicus 36,256
25-Nov-97 GB_RO: RNU91516 1540 U91516 Rattus norvegicus oxytocin
receptor (OTR) gene, promoter region. Rattus norvegicus 37,176
25-Nov-97 rxa02218 390 GB_HTG3: AC008656 43033 AC008656 Homo
sapiens chromosome 5 clone CIT978SKB_194J6, *** SEQUENCING Homo
sapiens 39,894 3-Aug-99 IN PROGRESS ***, 64 unordered pieces.
GB_HTG3: AC008656 43033 AC008656 Homo sapiens chromosome 5 clone
CIT978SKB_194J6, *** SEQUENCING IN Homo sapiens 39,894 3-Aug-99
PROGRESS ***, 64 unordered pieces. rxa02219 1509 GB_PR3: HS475N16
113109 AL035587 Human DNA sequence from clone 475N16 on chromosome
Homo sapiens 36,266 23-Nov-99 6p12.3-21.2, complete sequence.
GB_PR3: HS475N16 113109 AL035587 Human DNA sequence from clone
475N16 on Homo sapiens 35,255 23-Nov-99 chromosome 6p12.3-21.2,
complete sequence. GB_EST10: AA142336 411 AA142336 ms07f02.r1
Stratagene mouse skin (#937313) Mus musculus cDNA Mus musculus
38,398 12-Feb-97 clone IMAGE: 606267 5' similar to SW: RCA1_YEAST
P40341 MITOCHONDRIAL RESPIRATORY CHAIN COMPLEXES ASSEMBLY PROTEIN
RCA1;, mRNA sequence. rxa02221 1485 GB_PR3: AC002422 160091
AC002422 Human Chromosome X, complete sequence. Homo sapiens 38,435
30-Jan-98 GB_HTG2: AC006755 199917 AC006755 Caenorhabditis elegans
clone Y40C5, *** SEQUENCING Caenorhabditis elegans 39,229 23-Feb-99
IN PROGRESS ***, 1 unordered pieces. GB_HTG2: AC006755 199917
AC006755 Caenorhabditis elegans clone Y40C5, *** SEQUENCING
Caenorhabditis elegans 39,229 23-Feb-99 IN PROGRESS ***, 1
unordered pieces. rxa02223 601 GB_HTG6: AC008224 199774 AC008224
Drosophila melanogaster chromosome 3 clone Drosophila melanogaster
35,333 24-Nov-99 BACR29J02 (D817) RPCI-98 29.J.2 map 83D-83D strain
y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 37 unordered pieces.
GB_HTG3: AC011511 158296 AC011511 Homo sapiens chromosome 19 clone
CITB-H1_2369P2, Homo sapiens 35,593 07-OCT-1999 *** SEQUENCING IN
PROGRESS ***, 57 unordered pieces. GB_HTG3: AC011511 158296
AC011511 Homo sapiens chromosome 19 clone CITB-H1_2369P2, ***
SEQUENCING Homo sapiens 35,593 07-OCT-1999 IN PROGRESS ***, 57
unordered pieces. rxa02226 1156 GB_HTG2: AC006890 298195 AC006890
Caenorhabditis elegans clone Y67D8x, *** SEQUENCING Caenorhabditis
elegans 36,81 24-Feb-99 IN PROGRESS ***, 23 unordered pieces.
GB_HTG2: AC006890 298195 AC006890 Caenorhabditis elegans clone
Y67D8x, *** SEQUENCING Caenorhabditis elegans 35,433 24-Feb-99 IN
PROGRESS ***, 23 unordered pieces. GB_HTG2: AC006890 298195
AC006890 Caenorhabditis elegans clone Y67D8x, *** SEQUENCING
Caenorhabditis elegans 36,81 24-Feb-99 IN PROGRESS ***, 23
unordered pieces. rxa02227 741 GB_EST5: H98835 440 H98835
yx14f12.s1 Soares melanocyte 2NbHM Homo sapiens cDNA Homo sapiens
38,182 15-DEC-1995 clone IMAGE: 261743 3', mRNA sequence. GB_EST5:
N25530 586 N25530 yx76c03.s1 Soares melanocyte 2NbHM Homo sapiens
cDNA clone Homo sapiens 37,543 29-DEC-1995 IMAGE: 267652 3', mRNA
sequence. GB_BA1: CGU43535 2531 U43535 Corynebacterium glutamicum
multidrug resistance Corynebacterium 38,812 9-Apr-97 protein (cmr)
gene, complete cds. glutamicum rxa02230 660 GB_EST16: AA570388 527
AA570388 nk62c08.s1 NCI_CGAP_Sch1 Homo sapiens cDNA Homo sapiens
41,096 9-Sep-97 clone IMAGE: 1018094 3' similar to contains element
MSR1 repetitive element;, mRNA sequence. GB_PR2: HSU43030 1539
U43030 Human cardiotrophin-1 (CTF1) mRNA, complete cds. Homo
sapiens 36,335 9-Jan-96 GB_IN1: CELK08B5 35728 U41022
Caenorhabditis elegans cosmid K08B5. Caenorhabditis elegans 35,387
30-Nov-95 rxa02231 879 GB_PL2: ATAC006429 94818 AC006429
Arabidopsis thaliana chromosome II BAC F15K19 Arabidopsis thaliana
33,687 23-Apr-99 genomic sequence, complete sequence. GB_PR3:
AC004554 195142 AC004554 Homo sapiens Xp22 BAC GSHB-590J6 (Genome
Systems Homo sapiens 38,921 30-MAY-1998 Human BAC library) complete
sequence. GB_HTG2: AC007853 116280 AC007853 Drosophila melanogaster
chromosome 3 clone Drosophila melanogaster 36,237 2-Aug-99
BACR03L02 (D766) RPCI-98 03.L.2 map 96B-96C strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 80 unordered pieces. rxa02238 408
GB_BA1: MTCY21BA 39150 Z80108 Mycobacterium tuberculosis H37Rv
Mycobacterium 52,206 23-Jun-98 complete genome; segment 62/162.
tuberculosis GB_BA1: MTCY21B4 39150 Z80108 Mycobacterium
tuberculosis H37Rv Mycobacterium 36,935 23-Jun-98 complete genome;
segment 62/162. tuberculosis GB_VI: AF105451 801 AF105451 HIV-1
isolate A-DII-07 from Italy, envelope glycoprotein, C2-V5 region
Human immunodeficiency 40,864 25-Apr-99 (env) gene, partial cds.
virus type 1 rxa02244 1656 GB_PR1: AB016195 10558 AB016195 Homo
sapiens ELK1 pseudogene (ELK2) and immunoglobulin Homo sapiens
38,929 9-Apr-99 heavy chain gamma pseudogene (IGHGP). GB_PR3:
HSN21F1 39212 Z94162 Human DNA sequence from cosmid N21F1 on
chromosome 22 Contains Homo sapiens 38,763 23-Nov-99 exon trap and
STS, complete sequence. GB_IN1: DMAC001648 51989 AC001648
Drosophila melanogaster (P1 DS03431 (D102)) DNA Drosophila
melanogaster 36,884 22-Apr-97 sequence, complete sequence. rxa02254
800 GB_GSS12: AQ360240 541 AQ360240 HS_5035_A2_E07_T7 RPCI11 Human
Male Homo sapiens 36,386 06-MAR-1999 BAC Library Homo sapiens
genomic clone Plate = 611 Col = 14 Row = I, genomic survey
sequence. GB_GSS11: AQ258453 620 AQ258453 nbxb0020L15f CUGI Rice
BAC Library Oryza sativa genomic clone Oryza sativa 36,271
23-OCT-1998 nbxb0020L15f, genomic survey sequence. GB_GSS14:
AQ577777 568 AQ577777 nbxb0091L17f CUGI Rice BAC Library Oryza
sativa genomic clone Oryza sativa 39,456 2-Jun-99 nbxb0091L17f,
genomic survey sequence. rxa02255 1059 GB_PR4: AC006332 153477
AC006332 Homo sapiens clone NH0376O14, complete sequence. Homo
sapiens 35,019 11-Nov-99 GB_PAT: E02669 1197 E02669 DNA encoding
Bacillus sp. L-lactic acid dehydrogenase. Bacillus sp. 39,719
29-Sep-97 GB_PL1: YSCBOI2 3201 D38310 Yeast BOI2 gene for Boi2p.
Saccharomyces cerevisiae 35,769 8-Feb-99 rxa02266 636 GB_BA1:
REGIONB 4961 Z13995 N. meningitidis lipA and lipB genes for LipA
and LipB proteins. Neisseria meningitidis 35,691 29-DEC-1993
GB_HTG1: AP000568 136627 AP000568 Homo sapiens chromosome 21 clone
B753B2 map 21q21.2, Homo sapiens 37,5 07-OCT-1999 *** SEQUENCING IN
PROGRESS ***, in unordered pieces. GB_HTG1: AP000568 136627
AP000568 Homo sapiens chromosome 21 clone B753B2 map 21q21.2, ***
SEQUENCING Homo sapiens 37,5 07-OCT-1999 IN PROGRESS ***, in
unordered pieces. rxa02267 996 GB_PR4: AC007283 127361 AC007283
Homo sapiens clone NH0536I18, complete sequence. Homo sapiens
37,155 28-Sep-99 GB_IN1: CEC54C6 35500 Z77131 Caenorhabditis
elegans cosmid C54C6, complete sequence. Caenorhabditis elegans
38,28 23-Nov-98 GB_HTG3: AC008905 129915 AC008905 Homo sapiens
chromosome 5 clone CITB-H1_2259I14, *** SEQUENCING Homo sapiens
35,895 3-Aug-99 IN PROGRESS ***, 40 unordered pieces. rxa02271 681
GB_HTG3: AC007441 219832 AC007441 Drosophila melanogaster
chromosome 3 clone BACR10E03 Drosophila melanogaster 33,284
08-OCT-1999 (D690) RPCI-98 10.E.3 map 88A-88B strain y; cn bw sp,
*** SEQUENCING IN PROGRESS***, 188 unordered pieces. GB_HTG3:
AC007441 219832 AC007441 Drosophila melanogaster chromosome 3 clone
BACR10E03 (D690) Drosophila melanogaster 33,284 08-OCT-1999
RPCI-98 10.E.3 map 88A-88B strain y; cn bw sp, *** SEQUENCING IN
PROGRESS ***, 188 unordered pieces. GB_HTG2: AC008029 123186
AC008029 Drosophila melanogaster chromosome 3 clone BACR01C11
(D819) RPCI-96 01.C.11 Drosophila melanogaster 34,315 2-Aug-99 map
84D-84D strain y: cn bw sp, *** SEQUENCING IN PROGRESS ***, 92
unordered pieces. rxa02279 1581 GB_IN1: AC003121 69822 AC003121
Drosophila melanogaster (P1 DS00329 (D89)) DNA Drosophila
melanogaster 38,046 26-Nov-97 sequence, complete sequence. GB_IN1:
AC003121 69822 AC003121 Drosophila melanogaster (P1 DS00329 (D89))
DNA Drosophila melanogaster 39,22 26-Nov-97 sequence, complete
sequence. GB_BA1: MTCY39 38500 Z74025 Mycobacterium tuberculosis
H37Rv Mycobacterium 39,685 17-Jun-98 complete genome; segment
89/162. tuberculosis rxa02280 rxa02286 672 GB_BA1: MTV025 121125
AL022121 Mycobacterium tuberculosis H37Rv complete genome; segment
155/162. Mycobacterium 36,953 24-Jun-99 tuberculosis GB_PL2:
AC002130 114738 AC002130 The sequence of BAC F1N21 from Arabidopsis
thaliana chromosome Arabidopsis thaliana 39,216 8-Jan-98 1,
complete sequence. GB_PL2: AC007259 97146 AC007259 Arabidopsis
thaliana chromosome I BAC T28P6 genomic sequence, Arabidopsis
thaliana 36,09 17-Aug-99 complete sequence. rxa02287 675 GB_HTG3:
AC009281 221178 AC009281 Homo sapiens chromosome 15 clone 8_C_22
map 15, Homo sapiens 35,565 12-Aug-99 *** SEQUENCING IN PROGRESS
***, 49 unordered pieces. GB_HTG3: AC009281 221178 AC009281 Homo
sapiens chromosome 15 clone 8_C_22 map 15, *** SEQUENCING Homo
sapiens 35,565 12-Aug-99 IN PROGRESS ***, 49 unordered pieces.
GB_RO: MUSMURINC 4597 M65736 Mouse murinoglobulin mRNA, complete
cds. Mus musculus 38,485 27-Apr-93 rxa02294 498 GB_EST19: AA813194
398 AA813194 ai80g12.s1 Soares_testis_NHT Homo sapiens cDNA clone
Homo sapiens 36,797 31-DEC-1998 1377190 3', mRNA sequence.
GB_EST19: AA813194 398 AA813194 ai80g12.s1 Soares_testis_NHT Homo
sapiens cDNA clone Homo sapiens 33,417 31-DEC-1998 1377190 3', mRNA
sequence. rxa02295 903 GB_PAT: I89451 18318 I89451 Sequence 6 from
patent US 5721354. Unknown. 38,839 10-Aug-98 GB_VI: HCU33331 18535
U33331 Human cytomegalovirus Toledo strain UL/b' region. human
herpesvirus 5 38,839 27-Jan-96 GB_PR3: HS550H1 108803 AL035420
Human DNA sequence from clone 550H1 on chromosome 20q11.1-11.22
Contains Homo sapiens 38,796 23-Nov-99 a pseudogene similar to HIGH
MOBILITY GROUP PROTEIN 2A, a novel mRNA, ESTs, STSs, GSSs and CpG
Islands, complete sequence. rxa02296 612 GB_BA2: AF065312 1694
AF065312 Yersinia pestis hypothetical protein (yceG) gene, partial
cds; thymidylate Yersinia pestis 41,351 16-Nov-99 kinase (tmk)
gene, complete cds; and putative DNA polymerase III delta' subunit
(hoIB) gene, partial cds. GB_PR3: HS550H1 108803 AL035420 Human DNA
sequence from clone 550H1 on chromosome 20q11.1-11.22 Contains Homo
sapiens 37,919 23-Nov-99 a pseudogene similar to HIGH MOBILITY
GROUP PROTEIN 2A, a novel mRNA, ESTs, STSs, GSSs and CpG Islands,
complete sequence. GB_PR3: HS550H1 108803 AL035420 Human DNA
sequence from clone 550H1 on chromosome 20q11.1-11.22 Contains Homo
sapiens 37,607 23-Nov-99 a pseudogene similar to HIGH MOBILITY
GROUP PROTEIN 2A, a novel mRNA, ESTs, STSs, GSSs and CpG Islands,
complete sequence. rxa02297 1260 GB_BA2: AF065312 1694 AF065312
Yersinia pestis hypothetical protein (yceG) gene, partial cds;
Yersinia pestis 39,683 16-Nov-99 thymidylate kinase (tmk) gene,
complete cds; and putative DNA polymerase III delta' subunit (hoIB)
gene, partial cds. GB_RO: AF007836 5655 AF007836 Rattus norvegicus
rab3 effector (RIM) mRNA, alternatively spliced, complete cds.
Rattus norvegicus 37,844 15-Aug-97 GB_IN2: EGU27015 2394 U27015
Echinococcus granulosus 18S ribosomal RNA gene, complete sequence.
Echinococcus granulosus 38,71 16-Jul-96 rxa02298 1782 GB_BA2:
AF116184 540 AF116184 Corynebacterium glutamicum
L-aspartate-alpha-decarboxylase precursor Corynebacterium 44,231
02-MAY-1999 (panD) gene, complete cds. glutamicum GB_BA2: AF116184
540 AF116184 Corynebacterium glutamicum
L-aspartate-alpha-decarboxylase precursor Corynebacterium 42,007
02-MAY-1999 (panD) gene, complete cds. glutamicum rxa02300 456
GB_BA2: AF116184 540 AF116184 Corynebacterium glutamicum
L-aspartate-alpha-decarboxylase precursor Corynebacterium 46,25
02-MAY-1999 (panD) gene, complete cds. glutamicum GB_BA1: MTV004
69350 AL009198 Mycobacterium tuberculosis H37Rv complete
Mycobacterium 39,602 18-Jun-98 genome; segment 144/162.
tuberculosis GB_EST22: AI048692 172 AI048692 ub30g04.r1 Soares
2NbMT Mus musculus cDNA clone IMAGE: 1379286 5', Mus musculus
43,284 8-Jul-98 mRNA sequence. rxa02301 840 GB_HTG3: AC008573
205755 AC008573 Homo sapiens chromosome 5 clone CIT-HSPC_551I11,
*** SEQUENCING Homo sapiens 35,115 3-Aug-99 IN PROGRESS ***, 95
unordered pieces. GB_HTG3: AC008573 205755 AC008573 Homo sapiens
chromosome 5 clone CIT-HSPC_551I11, *** SEQUENCING Homo sapiens
35,115 3-Aug-99 IN PROGRESS ***, 95 unordered pieces. GB_HTG3:
AC008573 205755 AC008573 Homo sapiens chromosome 5 clone
CIT-HSPC_551I11, *** SEQUENCING Homo sapiens 36,527 3-Aug-99 IN
PROGRESS ***, 95 unordered pieces. rxa02302 1002 GB_HTG6: AC008076
200000 AC008076 Homo sapiens chromosome 4, *** SEQUENCING IN Homo
sapiens 34,884 02-DEC-1999 PROGRESS ***, 18 unordered pieces.
GB_HTG3: AC008930 258026 AC008930 Homo sapiens chromosome 5 clone
CITB-H1_2292M9, *** SEQUENCING Homo sapiens 36,945 3-Aug-99 IN
PROGRESS ***, 166 unordered pieces. GB_HTG3: AC008930 258026
AC008930 Homo sapiens chromosome 5 clone CITB-H1_2292M9, ***
SEQUENCING Homo sapiens 36,945 3-Aug-99 IN PROGRESS ***, 166
unordered pieces. rxa02303 rxa02304 1014 GB_PAT: A69720 53789
A69720 Sequence 3 from Patent WO9807868. unidentified 36,915
07-MAY-1999 GB_BA1: AMM223012 53784 AJ223012 Amycolatopsis
mediterranel genes encoding rifamycin polyketide Amycolatopsis
36,915 9-Feb-98 synthases, ORFs 1 to 5. mediterranel GB_BA2:
AF040570 76199 AF040570 Amycolatopsis mediterranel rifamycin
Amycolatopsis 36,915 15-Feb-98 biosynthetic gene cluster.
mediterranel rxa02307 rxa02308 552 GB_HTG3: AC009340 110415
AC009340 Drosophila melanogaster chromosome 2 clone BACR04E19
Drosophila melanogaster 36,066 27-Aug-99 (D1026) RPCI-98 04.E.19
map 34A-34E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 103
unordered pieces. GB_HTG3: AC009340 110415 AC009340 Drosophila
melanogaster chromosome 2 clone BACR04E19 Drosophila melanogaster
36,066 27-Aug-99 (D1026) RPCI-98 04.E.19 map 34A-34E strain y; cn
bw sp, *** SEQUENCING IN PROGRESS ***, 103 unordered pieces.
GB_IN2: AC005656 48443 AC005656 Drosophila melanogaster, chromosome
2R, region 34B6-34C2, Drosophila melanogaster 46,154 6-Feb-99 P1
clone DS08787, complete sequence. rxa02314 564 GB_HTG5: AC011247
206436 AC011247 Homo sapiens clone NH0541E12, WORKING DRAFT Homo
sapiens 36,201 13-Nov-99 SEQUENCE, 1 unordered pieces. GB_HTG5:
AC011247 206436 AC011247 Homo sapiens clone NH0541E12, WORKING
DRAFT Homo sapiens 35,036 13-Nov-99 SEQUENCE, 1 unordered pieces.
GB_HTG3: AC011152 142616 AC011152 Homo sapiens clone 7_H_4, Homo
sapiens 35,548 01-OCT-1999 LOW-PASS SEQUENCE SAMPLING. rxa02324
1209 GB_BA2: AF110185 20302 AF110185 Burkholderia pseudomallei
strain 1026b DbhB (dbhB), Burkholderia pseudomallei 39,67 2-Aug-99
general secretory pathway protein D (gspD), general secretory
pathway protein E (gspE), general secretory pathway protein F
(gspF), GspC (gspC), general secretory pathway protein G (gspG),
general secretory pathway protein H (gspH), general secretory
pathway protein I (gspI), general secretory pathway protein J
(gspJ), general secretory pathway protein K (gspK), general
secretory pathway protein L (gspL), general secretory pathway
protein M (gspM), and general secretory pathway protein N (gspN)
genes, complete cds; and unknown genes. GB_BA1: PSEAMNH 5215 D90216
P. chlororaphis genes for amidase (EC 3.5.1.4) Pseudomonas
chlororaphis 51,254 7-Feb-99 and for nitrile hydratase (EC
4.2.1.84). GB_PAT: E12519 4775 E12519 Nucleotide sequence of
Rhodococcus rhodochrous genomic Rhodococcus rhodochrous 51,646
24-Jun-98 DNA region containing amidase and nitrilehydratase genes.
rxa02325 990 GB_BA1: CGPYC 3728 Y09548 Corynebacterium glutamicum
pyc gene. Corynebacterium 100 08-MAY-1998 glutamicum GB_PR4:
AC006079 178109 AC006079 Homo sapiens chromosome 17, clone Homo
sapiens 37,807 12-DEC-1998 hRPK.855_D_21, complete sequence.
GB_GSS8: AQ036832 441 AQ036832 CIT-HSP-2334L1.TF CIT-HSP Homo
sapiens genomic Homo sapiens 42,359 11-Jul-98 clone 2334L1, genomic
survey sequence. rxa02331 489 GB_PL1: YSKGA11 4159 M68870
Kluyveromyces lactis transcriptional Kluyveromyces lactis 40,252
14-MAY-1993 activator (GAL11) gene, complete cds. GB_PR2: HSAY18950
584 Y18950 Homo sapiens partial gene for Homo sapiens 40,529
08-OCT-1999 caspase-9, intronic sequence (584 bp). GB_PL1: YSKGA11
4159 M68870 Kluyveromyces lactis transcriptional activator
Kluyveromyces lactis 38,679 14-MAY-1993 (GAL11) gene, complete cds.
rxa02336 303 GB_BA1: CGU35023 3195 U35023 Corynebacterium
glutamicum thiosulfate Corynebacterium 35,548 16-Jan-97
sulfurtransferase (thtR) gene, partial cds, acyl CoA glutamicum
carboxylase (accBC) gene, complete cds. GB_PL2: AF114171 183990
AF114171 Sorghum bicolor BAC clone 25.M18, complete sequence.
Sorghum bicolor 41,414 25-Apr-99 GB_PR4: AC006324 157310 AC006324
Homo sapiens clone DJ1164F05, complete sequence. Homo sapiens
41,786 11-Nov-99 rxa02337 1446 GB_BA1: CGU35023 3195 U35023
Corynebacterium glutamicum thiosulfate Corynebacterium 100
16-Jan-97 sulfurtransferase (thtR) gene, partial cds, acyl CoA
carboxylase glutamicum (accBC) gene, complete cds. GB_BA1: MTCY22G8
22550 Z95585 Mycobacterium tuberculosis H37Rv Mycobacterium 38,072
17-Jun-98 complete genome; segment 49/162. tuberculosis GB_PR2:
HSAY18950 584 Y18950 Homo sapiens partial gene for caspase-9, Homo
sapiens 42,949 08-OCT-1999 Intronic sequence (584 bp). rxa02339 515
GB_PR2: HS149A16 173354 AL021937 Human DNA sequence from clone
149A16 Homo sapiens 37,376 23-Nov-99 on chromosome 22q12-13.
Contains an IGLC (Immunoglobulin Lambda Chain C) pseudogene, the
RFPL3 and RFPL3S genes for Ret finger protein-like 3 and Ret finger
protein-like 3 antisense respectively, a gene for a novel
Immunoblobulin Lambda Chain V family protein, a novel gene for a
protein similar to mouse RGDS (RALGDS, RALGEF, Guanine Nucleotide
Dissoclation Stimulator A) and rabbit oncogene RSC, a novel gene
for the human ortholog of worm F16A11.2 and bacterial and
archea-bacterial predicted proteins, a novel gene for a protein
similar to BPI (Bacterial Permeability-Increasing Protein) and
rabbit LBP (Liposaccharide-Binding Protein), and a the 5' part of a
novel gene. Contains ESTs, STSs, GSSs, genomic marker D22S1175, a
ca repeat polymorphism and putative CpG islands, complete sequence.
GB_HTG3: AC009726 177618 AC009726 Homo sapiens chromosome 18 clone
263_O_14 map 18, Homo sapiens 37,037 29-Aug-99 *** SEQUENCING IN
PROGRESS ***, 12 unordered pieces. GB_HTG3: AC009726 177618
AC009726 Homo sapiens chromosome 18 clone 263_O_14 map 18, Homo
sapiens 37,037 29-Aug-99 *** SEQUENCING IN PROGRESS ***, 12
unordered pieces. rxa02340 1188 GB_VI: AF063866 236120 AF063866
Melanoplus sanguinipes entomopoxvirus, complete genome. Melanoplus
sanguinipes 34,48 22-DEC-1998 entomopoxvirus GB_HTG4: AC011089
171283 AC011089 Homo sapiens chromosome 2 clone 303_K_20 map 2,
Homo sapiens 37,757 14-OCT-1999 *** SEQUENCING IN PROGRESS ***, 25
ordered pieces. GB_HTG4: AC011089 171283 AC011089 Homo sapiens
chromosome 2 clone 303_K_20 map 2, Homo sapiens 37,757 14-OCT-1999
*** SEQUENCING IN PROGRESS ***, 25 ordered pieces. rxa02341 609
GB_GSS14: AQ580594 303 AQ580594 RPCI-11-452K5.TJ RPCI-11 Homo
sapiens genomic clone Homo sapiens 38,305 7-Jun-99 RPCI-11-452K5,
genomic survey sequence. GB_GSS12: AQ393454 561 AQ393454
CITBI-E1-2556E3.TR CITBI-E1 Homo sapiens genomic clone Homo sapiens
37,882 06-MAR-1999 2556E3, genomic survey sequence. GB_GSS14:
AQ507468 627 AQ507468 RPCI-11-298O19.TJ RPCI-11 Homo sapiens
genomic clone Homo sapiens 38,48 29-Apr-99 RPCI-11-298O19, genomic
survey sequence. rxa02347 444 GB_PR3: AC005549 147416 AC005549 Homo
sapiens chromosome 17, clone Homo sapiens 39,909 22-Sep-98
hRPK.215_E_13, complete sequence. GB_PR3: AC005549 147416 AC005549
Homo sapiens chromosome 17, clone Homo sapiens 33,784 22-Sep-98
hRPK.215_E_13, complete sequence. GB_GSS8: B92789 742 B92789
CIT-HSP-2164J8.TR CIT-HSP Homo sapiens genomic clone Homo sapiens
39,409 25-Jun-98 2164J8, genomic survey sequence.
rxa02349 rxa02352 578 GB_EST19: AA738949 396 AA738949 vv68d12.r1
Stratagene mouse skin (#937313) Mus musculus Mus musculus 36,023
14-Jan-98 cDNA clone IMAGE: 1227575 5', mRNA sequence. GB_GSS14:
AQ526017 500 AQ526017 HS_5329_A2_F02_T7A RPCI-11 Homo sapiens
38,537 11-MAY-1999 Human Male BAC Library Homo sapiens genomic
clone Plate = 905 Col = 4 Row = K, genomic survey sequence. GB_PR3:
U82695 167460 U82695 Homo sapiens cosmid LM1937 from Xq28. Homo
sapiens 38,421 3-Jan-98 rxa02358 1119 GB_BA1: MTCY16B7 43430 Z81331
Mycobacterium tuberculosis H37Rv complete Mycobacterium 39,087
17-Jun-98 genome; segment 123/162. tuberculosis GB_BA1: SRMSIK 2384
Y08921 S. reticuli gene encoding Msik protein and orf1.
Streptomyces reticuli 58,356 21-MAR-1997 GB_BA1: MSGY414A 40121
AD000007 Mycobacterium tuberculosis sequence from clone y414a.
Mycobacterium 58,423 03-DEC-1996 tuberculosis rxa02358 414 GB_BA1:
BSUB0021 215534 Z99124 Bacillus subtilis complete genome (section
21 of 21): from 3999281 to 4214814. Bacillus subtilis 36,829
26-Nov-97 GB_PR3: HSDA22P16 103367 AL049641 Human DNA sequence ***
SEQUENCING IN PROGRESS *** from clone Homo sapiens 36,43 23-Nov-99
DA22P16, complete sequence. GB_BA1: BSUB0021 215534 Z99124 Bacillus
subtilis complete genome (section 21 of 21): from 3999281 to
4214814. Bacillus subtilis 37,44 26-Nov-97 rxa02360 2556 GB_EST21:
AA970555 420 AA970555 oo94h05.s1 NCI_CGAP_Kid5 Homo sapiens cDNA
clone IMAGE: Homo sapiens 36,905 20-MAY-1998 1573881 3' similar to
gb: X61970 PROTEASOME ZETA CHAIN (HUMAN);, mRNA sequence. GB_GSS4:
AQ739589 909 AQ739589 HS_5381_B2_G06_T7A RPCI-11 Human Male BAC
Library Homo sapiens 44,912 16-Jul-99 Homo sapiens genomic clone
Plate = 957 Col = 12 Row = N, genomic survey sequence. GB_IN1:
CEY53H1C 37004 AL117201 Caenorhabditis elegans cosmid Y53H1C,
complete sequence. Caenorhabditis elegans 38,436 19-Nov-99 rxa02361
774 GB_IN2: CELK04F10 35413 AF039719 Caenorhabditis elegans cosmid
K04F10. Caenorhabditis elegans 36,891 26-MAY-1999 GB_PL1: AB011477
78181 AB011477 Arabidopsis thaliana genomic DNA, chromosome 5, P1
clone: MHK7, Arabidopsis thaliana 37,095 20-Nov-99 complete
sequence. GB_PL1: AB011477 78181 AB011477 Arabidopsis thaliana
genomic DNA, chromosome 5, P1 clone: MHK7, Arabidopsis thaliana
36,794 20-Nov-99 complete sequence. rxa02362 3822 GB_EST10:
AA178985 357 AA178985 zp12g08.s1 Stratagene fetal retina 937202
Homo sapiens cDNA Homo sapiens 39,875 31-DEC-1996 clone IMAGE:
609278 3', mRNA sequence. GB_GSS4: AQ710468 555 AQ710468
HS_5336_A2_B09_T7A RPCI-11 Human Male BAC Library Homo sapiens
39,82 13-Jul-99 Homo sapiens genomic clone Plate = 912 Col = 18 Row
= C, genomic survey sequence. GB_EST37: AI986900 380 AI986900
rs19a09.y1 Sommer Pristionchus Pristionchus pacificus cDNA clone
IMAGE: Pristionchus pacificus 42,105 1-Sep-99 5' similar to WP:
C06A1.1 CE02114 TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE HOMOLOG
1:, mRNA sequence. rxa02367 732 GB_BA2: SCF78 18292 AL121600
Streptomyces coelicolor cosmid F76. Streptomyces coelicolor 40,195
29-Sep-99 A3(2) GB_SY: SCU53587 4546 U53587 Artificial
Corynebacterium glutamicum IS1207-derived transposon synthetic
construct 36,755 06-MAY-1996 transposase genes, complete cds, and
3'5''-aminoglycoside phosphotransferase (aphA-3) gene, complete
cds. GB_PAT: E16763 2517 E16763 gDNA encoding aspartate transferase
(AAT). Corynebacterium 38,687 28-Jul-99 glutamicum rxa02368
rxa02374 744 GB_PL2: AC010924 80442 AC010924 Arabidopsis thaliana
chromosome 1 BAC 724D18 Arabidopsis thaliana 39,261 6-Nov-99
sequence, complete sequence. GB_VI: HE1CG 152261 X14112 Herpes
simplex virus (HSV) type 1 complete genome. human herpesvirus 1
39,856 17-Apr-97 GB_VI: HS1ULR 108360 D10879 Herpes simplex virus
type 1 long unique region UL. human herpesvirus 1 39,856 3-Feb-99
rxa02381 1146 GB_BA1: CGPROAGEN 1783 X82929 C. glutamicum proA
gene. Corynebacterium 98,974 23-Jan-97 glutamicum GB_BA1: CGPROAGEN
1783 X82929 C. glutamicum proA gene. Corynebacterium 37,156
23-Jan-97 glutamicum GB_GSS10: AQ215523 445 AQ215523
HS_2259_B2_F03_MR CIT Approved Human Genomic Homo sapiens 40,674
19-Sep-98 Sperm Library D Homo sapiens genomic clone Plate = 2259
Col = 6 Row = L, genomic survey sequence. rxa02383 736 GB_EST35:
AI810729 450 AI810729 tt86h09.x1 NCI_CGAP_Pr28 Homo sapiens cDNA
Homo sapiens 41,568 7-Jul-99 clone IMAGE: 2248481 3', mRNA
sequence. GB_EST22: AI048725 347 AI048725 ub31d01.r1 Soares 2NbMT
Mus musculus cDNA clone IMAGE: 1379329 5', Mus musculus 39,412
8-Jul-98 mRNA sequence. GB_EST15: AA466288 431 AA466288 vh34c01.r1
Barstead mouse pooled organs MPLRB4 Mus musculus cDNA clone Mus
musculus 39,336 11-Jun-97 IMAGE: 888864 5', mRNA sequence. rxa02387
885 GB_PR3: AC004687 175120 AC004687 Homo sapiens chromosome 17,
clone Homo sapiens 34,518 26-Jun-98 hRPC.1171_I_10, complete
sequence. GB_PR3: AC004687 175120 AC004687 Homo sapiens chromosome
17, clone Homo sapiens 38,551 26-Jun-98 hRPC.1171_I_10, complete
sequence. GB_GSS15: AQ604975 536 AQ604975 HS_2135_B2_G04_T7C CIT
Approved Human Genomic Homo sapiens 39,321 10-Jun-98 Sperm Library
D Homo sapiens genomic clone Plate = 2135 Col = 8 Row = N, genomic
survey sequence. rxa02390 792 GB_BA2: SC51A 42527 AL121596
Streptomyces coelicolor cosmid 51A. Streptomyces coelicolor 38,804
28-Sep-99 A3(2) GB_BA2: AF073776 5138 AF073776 Pseudomonas
aeruginosa MexZ (mexZ), complete cds; Pseudomonas aeruginosa 37,245
19-OCT-1998 and mexGH operon, complete sequence. GB_BA1: AB015853
5461 AB015853 Pseudomonas aeruginosa gene for MexX and MexY,
complete cds. Pseudomonas aeruginosa 40,641 13-Nov-98 rxa02393 405
GB_BA1: RCU57682 86896 U57682 Rhodobacter capsulatus cosmids
143-147, complete sequence. Rhodobacter capsulatus 44,246 7-Feb-97
GB_PL2: T2K10 88037 AC005966 Arabidopsis thaliana chromosome 1 BAC
T2K10 sequence, complete sequence. Arabidopsis thaliana 42,455
10-Feb-99 GB_PL2: T24H24 88848 AF075598 Arabidopsis thaliana BAC
T24H24. Arabidopsis thaliana 34,826 3-Aug-98 rxa02395 2013 GB_BA1:
SC5F2A 40105 AL049587 Streptomyces coelicolor cosmid 5F2A.
Streptomyces coelicolor 51,688 24-MAY-1999 GB_BA1: CGBETPGEN 2339
X93514 C. glutamicum betP gene. Corynebacterium 48,877 8-Sep-97
glutamicum GB_PL2: AF015436 682 AF015436 Liquidambar formosana
internal transcribed spacer 1, 5.8S Liquidambar formosana 36,217
1-Feb-99 ribosomal RNA gene; and internal transcribed spacer 2,
complete sequence. rxa02396 402 GB_BA2: AE000070 9973 AE000070
Rhizobium sp. NGR234 plasmid Rhizobium sp. NGR234 35,572
12-DEC-1997 pNGR234a, section 7 of 46 of the complete plasmid
sequence. GB_BA2: AE000070 9973 AE000070 Rhizobium sp. NGR234
plasmid pNGR234a, section 7 Rhizobium sp. NGR234 37,436 12-DEC-1997
of 46 of the complete plasmid sequence. GB_BA1: CVAJ677 1087
AJ000677 Chromatium vinosum recA gene. Allochromatium vinosum 37,5
8-Aug-97 rxa02398 1725 GB_PR1: HUMJUNA 3622 J04111 Human c-jun
proto oncogene (JUN), complete cds, clone hCJ-1. Homo sapiens
37,806 6-Jan-95 GB_EST35: AL041724 462 AL041724 DKFZp434O0317_r1
434 (synonym: htes3) Homo sapiens cDNA Homo sapiens 40,26 29-Sep-99
clone DKFZp434O0317 5', mRNA sequence. GB_PAT: I96176 3622 I96176
Sequence 13 from patent US 5734039. Unknown. 37,806 01-DEC-1998
rxa02403 888 GB_BA1: CGACEB 3024 X78491 C. glutamicum (ATCC 13032)
aceB gene. Corynebacterium 47,41 13-Jan-95 glutamicum GB_BA1:
CORACEB 2725 L27123 Corynebacterium glutamicum malate synthase
(aceB) gene, complete cds. Corynebacterium 43,981 8-Jun-95
glutamicum GB_IN1: CEK06A4 34006 Z70755 Caenorhabditis elegans
cosmid K06A4, complete sequence. Caenorhabditis elegans 37,875
23-Nov-98 rxa02406 672 GB_EST22: AI062160 629 AI062160
GH01261.5prime GH Drosophila melanogaster head Drosophila
melanogaster 37,687 24-Nov-98 pOT2 Drosophila melanogaster cDNA
clone GH01261 5prime, mRNA sequence. GB_PR1: HSRPIILS 6732 X63564
H. sapiens mRNA for RNA polymerase II largest subunit. Homo sapiens
36,486 13-Feb-92 GB_PR1: HSRPIILS 6732 X63564 H. sapiens mRNA for
RNA polymerase II largest subunit. Homo sapiens 38,813 13-Feb-92
rxa02407 495 GB_BA1: MTCY130 32514 Z73902 Mycobacterium
tuberculosis H37Rv complete genome; segment 59/162. Mycobacterium
54,321 17-Jun-98 tuberculosis GB_BA1: MSGY151 37036 AD000018
Mycobacterium tuberculosis sequence from clone y151. Mycobacterium
40 10-DEC-1996 tuberculosis GB_EST19: AA391133 474 AA391133
LD10081.5prime LD Drosophila melanogaster embryo BlueScript
Drosophila melanogaster 38,015 27-Nov-98 Drosophila melanogaster
cDNA clone LD0081 5prime, mRNA sequence. rxa02408 1035 GB_PAT:
I92047 551 I92047 Sequence 14 from patent US 5726299. Unknown. 46
01-DEC-1998 GB_PAT: I78759 549 I78759 Sequence 15 from patent US
5693781. Unknown. 45,438 3-Apr-98 GB_PAT: I92048 549 I92048
Sequence 15 from patent US 5726299. Unknown. 45,438 01-DEC-1998
rxa02409 660 GB_EST19: AA438982 672 AA438982 LD13390.5prime LD
Drosophila melanogaster embryo Drosophila melanogaster 36,13
27-Nov-98 BlueScript Drosophila melanogaster cDNA clone LD13390
5prime, mRNA sequence, GB_EST28: AI513795 635 AI513795
GH26887.5prime GH Drosophila melanogaster head Drosophila
melanogaster 38,84 16-MAR-1999 pOT2 Drosophila melanogaster cDNA
clone GH26887 5prime, mRNA sequence. GB_HTG3: AC009601 40300
AC009601 Leishmania major chromosome 35 clone L165 strain Friedlin,
Leishmania major 35,759 30-Sep-99 *** SEQUENCING IN PROGRESS ***, 2
ordered pieces. rxa02412 603 GB_BA1: AB020624 1605 AB020624
Corynebacterium glutamicum murl gene for D-glutamate
Corynebacterium 40,237 24-Jul-99 racemase, complete cds. glutamicum
GB_EST19: AA756805 646 AA756805 vv72b10.r1 Stratagene mouse skin
(#937313) Mus musculus cDNA Mus musculus 34,483 21-Jan-98 clone
IMAGE: 1227931 5' similar to gb: D21261 SM22-ALPHA HOMOLOG
(HUMAN);, mRNA sequence. GB_RO: AF149291 1388 AF149291 Mus musculus
transgelin mRNA, complete cds. Mus musculus 37,54 8-Jun-99 rxa02417
2247 GB_GSS14: AQ554774 813 AQ554774 RPCI-11-436G15.TV RPCI-11 Homo
sapiens genomic Homo sapiens 34,649 28-MAY-1999 clone
RPCI-11-436G15, genomic survey sequence. GB_GSS4: AQ713076 500
AQ713076 HS_5384_A2_C05_SP6E RPCI-11 Human Male BAC Library Homo
sapiens 35,2 13-Jul-99 Homo sapiens genomic clone Plate = 960 Col =
10 Row = E, genomic survey sequence. GB_STS: G47161 448 G47161
Z15758_1 Zebrafish AB Danio rerio STS genomic clone Z15758 5',
Danio rerio 39,91 23-MAR-1999 sequence tagged site. rxa02421 933
GB_HTG2: AC005708 76712 AC005708 Drosophila melanogaster chromosome
2 clone DS08537 (D425) Drosophila melanogaster 36,207 15-Jan-99 map
50C1-50C2 strain y2; cn bw sp, *** SEQUENCING IN PROGRESS ***, 20
unordered pieces. GB_HTG3: AC005812 76721 AC005812 Drosophila
melanogaster chromosome 2 clone DS07345 (D445) map Drosophila
melanogaster 36,205 20-Sep-99 50C1-50C2 strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 8 unordered pieces. GB_HTG2: AC005673
77023 AC005673 Drosophila melanogaster chromosome 2 clone DS00096
(D427) map Drosophila melanogaster 39,321 30-Jul-99 50C1-50C4
strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 12 unordered
pieces. rxa02425 653 GB_BA1: PFPHCOAHL 2700 Y13067 Pseudomonas
fluorescens genes encoding p-hydroxycinnamoyl CoA Pseudomonas
fluorescens 40,854 05-MAY-1998 hydratase/lyase and vanillin: NAD+
oxidoreductase. GB_EST27: AI438343 610 AI438343 SWOvAFCAP31F09SK
Onchocerca volvulus adult female cDNA Onchocerca volvulus 41,244
09-MAR-1999 (SAW98MLW-OvAF) Onchocerca volvulus cDNA clone
SWOvAFCAP31F09 5', mRNA sequence. GB_BA1: XANHRPA1A 1824 M99173
Xanthomonas campstris HrpA1 gene, complete cds. Xanthomonas
campestris 37,52 14-Sep-93 rxa02427 510 GB_OV: CCA245635 2455
AJ245635 Cyprinus carpio IL-1 gene for interleukin-1-beta. Cyprinus
carpio 35,614 5-Aug-99 GB_OV: AB010701 1213 AB010701 Cyprinus
carpio mRNA for interleukin-1 beta, complete cds. Cyprinus carpio
36,821 29-Jan-98 GB_OV: CCA245635 2455 AJ245835 Cyprinus carpio
IL-1 gene for interleukin-1-beta. Cyprinus carpio 35,06 5-Aug-99
rxa02428 1257 GB_IN1: CEY40B1B 29313 AL032636 Caenorhabditis
elegans cosmid Y40B1B, complete sequence. Caenorhabditis elegans
37,068 12-Nov-99 GB_GSS12: AQ374513 640 AQ374513 RPCI11-145N15.TJ
RPCI-11 Homo sapiens genomic clone Homo sapiens 35,636 20-MAY-1999
RPCI-11-145N15, genomic survey sequence. GB_IN1: CEY40B1B 29313
AL032636 Caenorhabditis elegans cosmid Y40B1B, complete sequence.
Caenorhabditis elegans 32,8 12-Nov-99 rxa02430 309 GB_BA1: MTCY1A11
30850 Z78020 Mycobacterium tuberculosis H37Rv complete genome:
segment 83/162. Mycobacterium 64,61 17-Jun-98 tuberculosis GB_PR4:
AC004998 135572 AC004998 Homo sapiens clone DJ164D05, complete
sequence. Homo sapiens 41,118 17-Jun-99 GB_PR2: AC002091 161799
AC002091 Genomic sequence from Human 17, complete sequence. Homo
sapiens 36,393 9-Sep-97 rxa02433 723 GB_HTG5: AC009754 212978
AC009754 Homo sapiens chromosome 15 clone RP11-519C12, WORKING
DRAFT Homo sapiens 33,008 17-Nov-99 SEQUENCE, 16 ordered pieces.
GB_HTG5: AC009754 212978 AC009754 Homo sapiens chromosome 15
clone
RP11-519C12, WORKING Homo sapiens 39,716 17-Nov-99 DRAFT SEQUENCE,
16 ordered pieces. GB_PR4: HUAC003108 164564 AC003108 Human
Chromosome 16 BAC clone Homo sapiens 35,18 23-Nov-99
CIT987SK-327O24, complete sequence. rxa02437 933 GB_IN2: AC005650
60019 AC005650 Drosophila melanogaster, chromosome 2R, region
59B4-59B7, Drosophila melanogaster 40,397 30-Jan-99 P1 clone
DS02885, complete sequence. GB_IN2: AC005650 60019 AC005650
Drosophila melanogaster, chromosome 2R, region Drosophila
melanogaster 37,719 30-Jan-99 59B4-59B7, P1 clone DS02885, complete
sequence. GB_RO: AF081193 2250 AF081193 Mus musculuscalcium and
DAG-regulated guanine nucleotide Mus musculus 37,835 28-Nov-98
exchange factor I mRNA, complete cds. rxa02443 1077 GB_HTG4:
AC009370 59409 AC009370 Drosophila melanogaster chromosome 3L/75C1
clone Drosophila melanogaster 35,46 16-OCT-1999 RPCI98-35F4, ***
SEQUENCING IN PROGRESS ***, 40 unordered pieces. GB_HTG4: AC009370
59409 AC009370 Drosophila melanogaster chromosome 3L/75C1 clone
RPCI98-35F4, Drosophila melanogaster 35,46 16-OCT-1999 ***
SEQUENCING IN PROGRESS ***, 40 unordered pieces. GB_EST9: AA081445
311 AA081445 zn18a01.r1 Stratagene neuroepithelium NT2RAMI 937234
Homo sapiens cDNA clone Homo sapiens 36,334 21-OCT-1996 IMAGE:
547752 5', mRNA sequence. rxa02444 1401 GB_BA2: SCF76 18292
AL121600 Streptomyces coelicolor cosmid F76. Streptomyces
coelicolor 39,226 29-Sep-99 A3(2) GB_PR2: HS1022J11 137658 AL049765
Human DNA sequence from clone 1022J11 on chromosome 20q13.13-13.2,
complete Homo sapiens 35,444 23-Nov-99 sequence. GB_HTG1: AC002345
132645 AC002345 Homo sapiens chromosome 17 clone 20D5, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 35,106 25-Aug-97 10
unordered pieces. rxa02452 303 GB_GSS14: AQ579499 825 AQ579499
nbxb0084D17f CUGI Rice BAC Library Oryza sativa genomic clone
nbxb0084D17f, Oryza sativa 39,535 2-Jun-99 genomic survey sequence.
GB_GSS14: AQ579499 825 AQ579499 nbxb0084D17f CUGI Rice BAC Library
Oryza sativa genomic clone nbxb0084D17f, Oryza sativa 36,213
2-Jun-99 genomic survey sequence. rxa02454 1365 GB_HTG3: AC007810
140175 AC007810 Drosophila melanogaster chromosome 3 clone
BACR14A01 (D720) RPCI-98 14.A.1 Drosophila melanogaster 33,931
17-Sep-99 map 90C--90C strain y; cn bw sp, *** SEQUENCING IN
PROGRESS ***, 89 unordered pieces. GB_HTG3: AC007810 140175
AC007810 Drosophila melanogaster chromosome 3 clone BACR14A01
(D720) RPCI-98 14.A.1 Drosophila melanogaster 33,931 17-Sep-99 map
90C--90C strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 89
unordered pieces. GB_PR3: AC005339 32360 AC005339 Homo sapiens
chromosome 19, cosmid R33729, complete sequence. Homo sapiens
38,131 30-Jul-98 rxa02457 1233 GB_HTG3: AC009346 105005 AC009346
Drosophila melanogaster chromosome 3 clone BACR03P13 (D672) RPCI-98
03.P.13 Drosophila melanogaster 36,829 27-Aug-99 map 83A-83B strain
y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 83 unordered pieces.
GB_EST20: AA820427 436 AA820427 LD24042.5prime LD Drosophila
melanogaster embryo pOT2 Drosophila Drosophila melanogaster 38,018
25-Feb-99 melanogaster cDNA clone LD24042 5prime, mRNA sequence.
GB_HTG3: AC009346 105005 AC009346 Drosophila melanogaster
chromosome 3 clone BACR03P13 (D672) RPCI-98 Drosophila melanogaster
36,829 27-Aug-99 03.P.13 map 83A-83B strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 83 unordered pieces. rxa02459 858
GB_BA2: AF114233 1852 AF114233 Corynebacterium glutamicum
5-enolpyruvylshikimate 3-phosphate synthase Corynebacterium 99,248
7-Feb-99 (aroA) gene, complete cds. glutamicum GB_HTG1: CEY45F10_2
110000 Z93245 Caenorhabditis elegans chromosome IV clone Y45F10,
*** SEQUENCING IN Caenorhabditis elegans 35,621 17-Sep-97 PROGRESS
***, in unordered pieces. GB_HTG1: CEY45F10_2 110000 Z93245
Caenorhabditis elegans chromosome IV clone Y45F10, *** SEQUENCING
IN Caenorhabditis elegans 35,621 17-Sep-97 PROGRESS ***, in
unordered pieces. rxa02460 rxa02461 531 GB_EST10: AA153371 590
AA153371 ms02a12.r1 Stratagene mouse embryonic carcinoma (#937317)
Mus musculus Mus musculus 39,203 11-Feb-97 cDNA clone IMAGE: 605758
5' similar to gb: M24194 GUANINE NUCLEOTIDE- BINDING PROTEIN BETA
SUBUNIT-LIKE PROTEIN (HUMAN); gb: X75313 M. musculus (MOUSE);, mRNA
sequence. GB_EST10: AA153371 590 AA153371 ms02a12.r1 Stratagene
mouse embryonic carcinoma (#937317) Mus musculus 41,92 11-Feb-97
Mus musculus cDNA clone IMAGE: 605758 5' similar to gb: M24194
GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT-LIKE PROTEIN
(HUMAN); gb: X75313 M. musculus (MOUSE):, mRNA sequence. rxa02464
1323 GB_HTG4: AC008754 86446 AC008754 Homo sapiens chromosome 19
clone CITB-E1_3023J11, Homo sapiens 36,064 31-OCT-1999 ***
SEQUENCING IN PROGRESS ***, 73 unordered pieces. GB_HTG4: AC008754
86446 AC008754 Homo sapiens chromosome 19 clone CITB-E1_3023J11,
Homo sapiens 36,064 31-OCT-1999 *** SEQUENCING IN PROGRESS ***, 73
GB_HTG4: AC008754 86446 AC008754 Homo sapiens chromosome 19 clone
CITB-E1_3023J11, Homo sapiens 37,589 31-OCT-1999 *** SEQUENCING IN
PROGRESS ***, 73 unordered pieces. rxa02465 522 GB_PR3: AC004960
143834 AC004960 Homo sapiens PAC clone DJ1098B01 from 7q11.23-q21,
complete sequence. Homo sapiens 35,01 5-Nov-98 GB_GSS9: AQ122158
428 AQ122158 HS_3083_A1_E10_MR CIT Approved Human Genomic Sperm
Library D Homo sapiens 39,72 22-Sep-98 Homo sapiens genomic clone
Plate = 3083 Col = 19 Row = I, genomic survey sequence. GB_BA2:
AF053227 840 AF053227 Photobacterium leiognathi probable flavin
reductase (luxG) gene, complete cds. Photobacterium leiognathi
37,572 12-Jun-98 rxa02466 187 GB_EST21: AA942401 825 AA942401
LD26583.5prime LD Drosophila melanogaster embryo pOT2 Drosophila
melanogaster 37,705 25-Nov-98 Drosophila melanogaster cDNA clone
LD26583 5prime, mRNA sequence. GB_GSS12: AQ400564 485 AQ400564
HS_5064_A1_G09_T7A RPCI-11 Human Male BAC Library Homo sapiens
38,043 13-MAR-1999 Homo sapiens genomic clone Plate = 640 Col = 17
Row = M, genomic survey sequence. GB_GSS12: AQ400564 485 AQ400564
HS_5064_A1_G09_T7A RPCI-11 Human Male BAC Library Homo sapiens
37,647 13-MAR-1999 Homo sapiens genomic clone Plate = 640 Col = 17
Row = M, genomic survey sequence. rxa02467 348 GB_HTG2: AC005718
149592 AC005718 Drosophila melanogaster chromosome 2 clone DS02336
(D440) map 60C8-60D2 Drosophila melanogaster 40,525 30-Jul-99
strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 68 unordered
pieces. GB_HTG2: AC005718 149592 AC005718 Drosophila melanogaster
chromosome 2 clone DS02336 (D440) map 60C8-60D2 Drosophila
melanogaster 40,525 30-Jul-99 strain y; cn bw sp, *** SEQUENCING IN
PROGRESS ***, 68 unordered pieces. GB_PR3: AC004217 103319 AC004217
Homo sapiens 12q24.1 PAC RPCI3-521E19 (Roswell Park Cancer Homo
sapiens 37,389 2-Jun-98 Institute Human PAC library) complete
sequence. rxa02472 414 GB_GSS12: AQ413964 550 AQ413964
RPCI-11-207C17.TV RPCI-11 Homo sapiens genomic clone
RPCI-11-207C17, Homo sapiens 37,87 23-MAR-1999 genomic survey
sequence. GB_IN2: CELR09H3 10687 U58740 Caenorhabditis elegans
cosmid R09H3. Caenorhabditis elegans 37,408 26-MAY-1999 GB_GSS13:
AQ488397 734 AQ488397 RPCI-11-243H14.TV RPCI-11 Homo sapiens
genomic clone RPCI-11-243H14, Homo sapiens 37,569 24-Apr-99 genomic
survey sequence. rxa02473 864 GB_HTG1: CEY7A5 235922 AL021576
Caenorhabditis elegans chromosome X clone Y7A5, *** SEQUENCING
Caenorhabditis elegans 38,561 19-Aug-99 IN PROGRESS ***, in
unordered pieces. GB_HTG1: CEY7A5 235922 AL021576 Caenorhabditis
elegans chromosome X clone Y7A5, *** SEQUENCING Caenorhabditis
elegans 38,561 19-Aug-99 IN PROGRESS ***, in unordered pieces.
GB_IN1: CEY7A5A 68270 AL034489 Caenorhabditis elegans cosmid Y7A5A,
complete sequence. Caenorhabditis elegans 38,081 18-DEC-1998
rxa02475 1278 GB_BA1: AB009078 2686 AB009078 Brevibacterium
saccharolyticum gene for L-2.3-butanediol Brevibacterium 99,217
13-Feb-99 dehydrogenase, complete cds. saccharolytlcum GB_PH:
AF074945 15644 AF074945 Mycoplasma arthritidis bacteriophage MAV1,
complete genome. Mycoplasma arthritidis 36,876 27-Jul-99
bacteriophage MAV1 GB_BA1: MTV008 63033 AL021246 Mycobacterium
tuberculosis H37Rv complete genome; segment 108/162. Mycobacterium
37,52 17-Jun-98 tuberculosis rxa02478 1338 GB_HTG1: AC002419 128340
AC002419 Homo sapiens chromosome X clone bWXD40, *** SEQUENCING IN
Homo sapiens 34,7 12-Aug-97 PROGRESS ***, 2 unordered pieces.
GB_PR3: AC004073 79612 AC004073 Human Chromosome X, complete
sequence. Homo sapiens 34,7 29-Jan-98 GB_HTG1: AC002419 128340
AC002419 Homo sapiens chromosome X clone bWXD40, *** SEQUENCING IN
Homo sapiens 34,7 12-Aug-97 PROGRESS ***, 2 unordered pieces.
rxa02482 933 GB_OV: AF077329 1645 AF077329 Coturnix coturnix
pro-alpha2(I) collagen mRNA, partial cds. Coturnix coturnix 40,202
3-Feb-99 GB_PL2: SFU59150 2854 U59150 Sartorya fumigata nucleolar
protein AfCbf5p (AfCBF5p) mRNA, complete cds. Aspergillus fumigatus
36,789 1-Jan-98 GB_BA2: AE000106 12554 AE000106 Rhizobium sp.
NGR234 plasmid pNGR234a, section 43 of 46 of the complete Rhizobium
sp. NGR234 36,63 12-DEC-1997 plasmid sequence. rxa02483 936
GB_HTG1: AC002345 132645 AC002345 Homo sapiens chromosome 17 clone
20D5, *** SEQUENCING IN PROGRESS***, Homo sapiens 37,942 25-Aug-97
10 unordered pieces. GB_HTG1: AC002345 132645 AC002345 Homo sapiens
chromosome 17 clone 20D5, *** SEQUENCING IN Homo sapiens 37,942
25-Aug-97 PROGRESS ***, 10 unordered pieces. GB_PR4: AF118569 24070
AF118569 Homo sapiens angiotensin I converting enzyme precursor
(DCP1) gene, alternative Homo sapiens 37,352 28-OCT-1999 splice
products, complete cds. rxa02484 624 GB_BA1: RLSPRLVCP 3696 Y09534
R. leguminosarum Symblosis Plasmid DNA, rlvCP gene. Rhizobium
leguminosarum 38,003 26-Feb-97 GB_BA2: RLU23040 3931 U23040
Rhizobium leguminosarum bv. viciae putative glycerol-3-phosphate
transport Rhizobium leguminosarum 38,003 26-Aug-96 protein (ugpC)
gene, partial cds, and chemoreceptor protein (mcpA), putative
2-hydroxychromene-2-carboxylate bv. viciae isomerase, and putative
alcohol dehydrogenase genes, complete cds. GB_BA1: NGORBKGME 1580
L07845 Neisseria gonorrhoeae ribokinase (rbk) gene, 3' end;
ADP-L-glycero-D- Neisseria gonorrhoeae 46,939 11-OCT-1995
mannoheptose epimerase (gme) gene, complete cds. rxa02486 759
GB_IN1: CELM02D8 40876 U41034 Caenorhabditis elegans cosmid M02D8.
Caenorhabditis elegans 38,358 30-Nov-95 GB_IN2: CELC36C5 41596
AF016444 Caenorhabditis elegans cosmid C36C5. Caenorhabditis
elegans 38,482 08-OCT-1999 GB_HTG3: AC011467 188118 AC011467 Homo
sapiens chromosome 19 clone CIT-HSPC_457E21, *** SEQUENCING Homo
sapiens 37,954 07-OCT-1999 IN PROGRESS ***, 59 unordered pieces.
rxa02488 392 GB_HTG2: AC006765 274498 AC006765 Caenorhabditis
elegans clone Y43H11, *** SEQUENCING IN PROGRESS ***,
Caenorhabditis elegans 38,961 23-Feb-99 7 unordered pieces.
GB_HTG2: AC006765 274498 AC006765 Caenorhabditis elegans clone
Y43H11, *** SEQUENCING IN PROGRESS ***, Caenorhabditis elegans
38,961 23-Feb-99 7 unordered pieces. GB_HTG4: AC010035 173152
AC010035 Drosophila melanogaster chromosome 3L/74B2 clone RPCO98-
Drosophila melanogaster 38,01 16-OCT-1999 6H1, *** SEQUENCING IN
PROGRESS ***, 60 unordered pieces. rxa02489 724 GB_GSS8: AQ050210
796 AQ050210 nbxb0003cD08r CUGI Rice BAC Library Oryza Sativa
genomic clone Oryza sativa 40,201 24-MAR-1999 nbxb0003H15r, genomic
survey sequence. GB_PL1: D87819 2036 D87819 Oryza sativa mRNA for
sucrose transporter, complete cds. Oryza sativa 39,356 26-DEC-1997
GB_STS: G53565 627 G53565 SHGC-83995 Human Homo sapiens STS
genomic, sequence tagged site. Homo sapiens 40,237 25-Jun-99
rxa02495 2691 GB_BA1: MTCY19H9 20679 Z83857 Mycobacterium
tuberculosis H37Rv complete genome; segment 129/162. Mycobacterium
40,853 18-Jun-98 tuberculosis GB_BA1: MTCY19H9 20679 Z83857
Mycobacterium tuberculosis H37Rv complete genome; segment 129/162.
Mycobacterium 40,358 18-Jun-98 tuberculosis GB_HTG1: HSDJ901O8
114599 AL078461 Homo sapiens chromosome 20 clone RP5-901O8 map
q11.1-11.23, Homo sapiens 34,059 25-Nov-99 *** SEQUENCING IN
PROGRESS ***, in unordered pieces. rxa02496 930 GB_EST36: AV201062
373 AV201062 AV201062 Yuji Kohara unpublished cDNA Caenorhabditis
elegans cDNA clone Caenorhabditis elegans 41,287 26-Jul-99 yk250f11
5', mRNA sequence. GB_IN1: CELC10F3 40172 AF022968 Caenorhabditis
elegans cosmid C10F3. Caenorhabditis elegans 35,217 10-Sep-97
GB_EST29: AI612578 357 AI612578 TENG0372 T. Cruzi epimastigote
normalised cDNA Library Trypanosoma cruzi Trypanosoma cruzi 39,474
7-Jul-99 cDNA clone n715.r 5', mRNA sequence. rxa02498 927 GB_BA2:
CGU31225 1817 U31225 Corynebecterium glutamicum L-proline: NADP+
5-oxidoreductase (proC) Corynebacterium 92,58 2-Aug-96 gene,
complete cds. glutamicum GB_PR2: AP000197 100000 AP000197 Homo
sapiens genomic DNA, chromosome 21q22.1, D21S226-AML region, Homo
sapiens 36,344 20-Nov-99 clone B355D16-T1073, segment 3/8, complete
sequence. GB_PR2: AP000093 100000 AP000093 Homo sapiens genomic DNA
of 21q22.1, GART and AML related, Homo sapiens 36,344 25-Sep-99
B335D16-P10G11 region, segment 3/7, complete sequence. rxa02500 222
GB_BA1: MTCY20G9 37218 Z77162 Mycobacterium tuberculosis H37Rv
complete genome; segment 25/162. Mycobacterium 58,257 17-Jun-98
tuberculosis
GB_BA1: U00018 42991 U00018 Mycobacterium leprae cosmid B2168.
Mycobacterium leprae 44,776 01-MAR-1994 GB_BA1: SCE68 38084
AL079345 Streptomyces coelicolor cosmid E68. Streptomyces
coelicolor 37,624 16-Jul-99 A3(2) rxa02505 294 GB_RO: MM2B4J 289
X00621 Mouse hybridoma 2B4 gene fragment (J-region) for T-cell
receptor. Mus musculus 36,364 10-Nov-95 GB_RO: MUSTCBJB1 2276
K02802 Mouse T-cell receptor germline beta-chain J-beta-2 gene
cluster, including J-beta- Mus musculus 32,862 27-Apr-93
[2.1,2.2,2.3,2.4,2.5,2.psi,2.6] genes. GB_RO: MMAE000665 199101
AE000665 Mus musculus TCR beta locus from bases 501860 to 700960
(section 3 of 3) Mus musculus 36,879 4-Sep-97 of the complete
sequence. rxa02506 rxa02510 759 GB_OM: PIGMTNADP 1585 M86719 Pig
mitochondrial NADP-isocitrate dehydrogenase mRNA, 3' end. Sus
scrofa 36,963 12-Jun-93 GB_EST17: AA629042 359 AA629042 zu77d08.s1
Soares_testis_NHT Homo sapiens cDNA clone IMAGE: 744015 3', Homo
sapiens 37,184 16-OCT-1997 mRNA sequence. GB_EST20: AA837524 528
AA837524 oe31d07.s1 NCI_CGAP_Pr25 Homo sapiens cDNA clone IMAGE:
1410157 similar Homo sapiens 40,039 26-Feb-98 to gb: X69391 60S
RIBOSOMAL PROTEIN L6 (HUMAN);, mRNA sequence. rxa02514 857 GB_PR2:
CNS01DS9 175148 AL121694 Human chromosome 14 DNA sequence *** IN
PROGRESS *** BAC R-701B16 of Homo sapiens 35,185 8-Nov-99 RPCI-11
library from chromosome 14 of Homo sapiens (Human), complete
sequence. GB_PR4: AC006222 165643 AC006222 Homo sapiens, clone
hRPK.12_A_1, complete sequence. Homo sapiens 33,411 15-Jan-99
GB_PR4: AC006222 165643 AC006222 Homo sapiens, clone hRPK.12_A_1,
complete sequence. Homo sapiens 35,629 15-Jan-99 rxa02518 534
GB_BA1: MTV007 32806 AL021184 Mycobacterium tuberculosis H37Rv
complete genome; segment 64/162. Mycobacterium 57,965 17-Jun-98
tuberculosis GB_EST16: AA576027 231 AA576027 nm57e05.s1
NCI_CGAP_Br3 Homo sapiens cDNA clone IMAGE: 1072352 Homo sapiens
47,674 9-Sep-97 3' similar to TR: G1001455 G1001455 HYPOTHETICAL
141.7 KD PROTEIN. ;, mRNA sequence. GB_BA2: AE000226 10466 AE000226
Escherichia coli K-12 MG1655 section 116 of 400 of the complete
genome. Escherichia coli 38,447 12-Nov-98 rxa02519 1752 GB_IN2:
DMNRG2 8574 AF050085 Drosophila melanogaster neuroglian (nrg) gene,
exons 3-6, 7a, 7b and alternatively Drosophila melanogaster 38,498
5-Aug-98 spliced products, complete cds. GB_IN2: AC004322 32480
AC004322 Drosophila melanogaster DNA sequence (P1 DS01962 (D216)),
complete sequence. Drosophila melanogaster 36,126 29-Aug-98
GB_HTG2: AC008188 129128 AC008188 Drosophila melanogaster
chromosome 2 clone BACR08I18 (D660) RPCI-98 08.I.18 Drosophila
melanogaster 35,66 2-Aug-99 map 56A2-56B1 strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 72 unordered pieces. rxa02520 807
GB_GSS3: B68449 228 B68449 CIT-HSP-2025P8.TF CIT-HSP Homo sapiens
genomic clone 2025P8, genomic Homo sapiens 42,544 21-Jun-98 survey
sequence. GB_HTG3: AC010642 45982 AC010642 Homo sapiens chromosome
19 clone LLNL-R_245B6, *** SEQUENCING Homo sapiens 34,543 16-Sep-99
IN PROGRESS ***, 26 unordered pieces. GB_HTG3: AC010642 45982
AC010642 Homo sapiens chromosome 19 clone LLNL-R_245B6, ***
SEQUENCING Homo sapiens 34,543 16-Sep-99 IN PROGRESS ***, 26
unordered pieces. rxa02521 1566 GB_BA1: SCC22 22115 AL096839
Streptomyces coelicolor cosmid C22. Streptomyces coelicolor 40,885
12-Jul-99 GB_BA1: BSUB0017 217420 Z99120 Bacillus subtilis complete
genome (section 17 of 21): from 3197001 to 3414420. Bacillus
subtilis 38,441 26-Nov-97 GB_BA1: MLCL536 36224 Z99125
Mycobacterium leprae cosmid L536. Mycobacterium leprae 37,233
04-DEC-1998 rxa02524 813 GB_IN1: CELF42H10 28687 L08403 C. elegans
cosmid F42H10. Caenorhabditis elegans 32,878 22-OCT-1993 GB_IN1:
CEU02289 4824 U02289 Caenorhabditis elegans Bristol N2
GTPase-activating protein (CEGAP) Caenorhabditis elegans 34,457
11-Jun-94 mRNA, partial cds. GB_IN1: CELF42H10 28687 L08403 C.
elegans cosmid F42H10. Caenorhabditis elegans 34,243 22-OCT-1993
rxa02525 501 GB_EST36: AU076280 416 AU076280 AU076280 Rice green
shoot Oryza sativa cDNA clone S10896_11A, mRNA Oryza sativa 42,671
27-Jul-99 sequence. GB_EST1: D34202 355 D34202 CELK042E5R Yuji
Kohara unpublished cDNA Caenorhabditis elegans cDNA Caenorhabditis
elegans 42,553 8-Aug-94 clone yk42e5 3', mRNA sequence. GB_EST1:
D34202 355 D34202 CELK042E5R Yuji Kohara unpublished cDNA
Caenorhabditis elegans cDNA Caenorhabditis elegans 37,892 8-Aug-94
clone yk42e5 3', mRNA sequence. rxa02534 927 GB_EST15: AA490533 426
AA490533 aa51h04.r1 NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE:
824503 5', Homo sapiens 41,176 15-Aug-97 mRNA sequence. GB_PL2:
ATFCA3 200252 Z97338 Arabidopsis thaliana DNA chromosome 4, ESSA I
FCA Arabidopsis thaliana 35,568 27-Aug-99 contig fragment No. 3.
GB_PL2: ATFCA3 200252 Z97338 Arabidopsis thaliana DNA chromosome 4,
ESSA I FCA contig Arabidopsis thaliana 37,376 27-Aug-99 fragment
No. 3. rxa02537 585 GB_HTG4: AC009732 165576 AC009732 Drosophila
melanogaster chromosome 2 clone BACR05E17 (D1059) Drosophila
melanogaster 30,727 26-OCT-1999 RPCI-98 05.E.17 map 57F--57F strain
y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 83 unordered pieces.
GB_HTG4: AC009732 165576 AC009732 Drosophila melanogaster
chromosome 2 clone BACR05E17 (D1059) Drosophila melanogaster 30,727
26-OCT-1999 RPCI-98 05.E.17 map 57F--57F strain y', cn bw sp, ***
SEQUENCING IN PROGRESS ***, 83 unordered pieces. GB_HTG4: AC009732
165576 AC009732 Drosophila melanogaster chromosome 2 clone
BACR05E17 (D1059) Drosophila melanogaster 36,46 26-OCT-1999 RPCI-98
05.E.17 map 57F--57F strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 83 unordered pieces. rxa02538 795 GB_GSS15: AQ606090 658
AQ606090 HS_5392_A1_E12_T7A RPCI-11 Human Male BAC Library Homo
sapiens Homo sapiens 39,369 10-Jun-99 genomic clone Plate = 968 Col
= 23 Row = l, genomic survey sequence. GB_BA1: AXACE 5323 X94981 A.
xylinum aceB, aceC, aceD, and aceE genes. Acetobacter xylinus
37,009 12-Feb-97 GB_BA1: AXACE 5323 X94981 A. xylinum aceB, aceC,
aceD, and aceE genes. Acetobacter xylinus 37,879 12-Feb-97 rxa02540
561 GB_BA1: MTY13E10 35019 Z95324 Mycobacterium tuberculosis H37Rv
complete genome; segment 18/162. Mycobacterium 51,002 17-Jun-98
tuberculosis GB_BA1: MTDNAGRP 4644 X58406 M. tuberculosis dnaK,
grpE, and dnaJ genes. Mycobacterium 51,002 21-OCT-1992 tuberculosis
GB_BA1: AB007847 2400 AB007847 Rhodococcus rhodochrous gene for
3-ketosteroid-delta1-dehydrogenase, complete cds. Rhodococcus
rhodochrous 53,723 13-Feb-99 rxa02544 1521 GB_PAT: E14041 2776
E14041 gDNA encoding laminaripentaose forming enzyme (LPHase).
Streptomyces sp. 47,351 28-Jul-99 GB_HTG3: AC010592 45971 AC010592
Homo sapiens chromosome 5 clone CIT-HSPC_459H20, *** SEQUENCING IN
Homo sapiens 37,689 16-Sep-99 PROGRESS ***, 38 unordered pieces.
GB_HTG3: AC010592 45971 AC010592 Homo sapiens chromosome 5 clone
CIT-HSPC_459H20, *** SEQUENCING IN Homo sapiens 37,689 16-Sep-99
PROGRESS ***, 38 unordered pieces. rxa02545 681 GB_HTG3: AC009016
128095 AC009016 Homo sapiens chromosome 5 clone P1_889E7, ***
SEQUENCING Homo sapiens 34,763 3-Aug-99 IN PROGRESS ***, 67
PROGRESS ***, 67 unordered pieces. GB_HTG3: AC009016 128095
AC009016 Homo sapiens chromosome 5 clone P1_889E7, *** SEQUENCING
Homo sapiens 34,763 3-Aug-99 IN PROGRESS ***, 67 unordered pieces.
GB_HTG3: AC009010 72817 AC009010 Homo sapiens chromosome 5 clone
P1_1352A1, *** SEQUENCING Homo sapiens 34,763 3-Aug-99 IN PROGRESS
***, 19 unordered pieces. rxa02546 1227 GB_HTG3: AC006519 134365
AC006519 Homo sapiens clone RPCI5-951N9, *** SEQUENCING IN Homo
sapiens 32,868 16-Sep-99 PROGRESS ***, 41 unordered pieces. GB_BA1:
D90738 17528 D90738 Escherichia coli genomic DNA. (23.0-23.4 min).
Escherichia coli 38,674 7-Feb-99 GB_HTG3: AC006519 134365 AC006519
Homo sapiens clone RPCI5-951N9, *** SEQUENCING IN PROGRESS ***,
Homo sapiens 32,868 16-Sep-99 41 unordered pieces. rxa02549 2826
GB_BA1: CGBPHI16 962 Y12472 C. glutamicum DNA, attachment site
bacteriophage Phi-16. Corynebacterium 41,702 05-MAR-1999 glutamicum
GB_BA2: AE001095 10592 AE001095 Archaeoglobus fulgidus section 12
of 172 of the complete genome. Archaeoglobus fulgidus 36,817
15-DEC-1997 GB_EST20: AA887411 587 AA887411 oj37d06.s1 NCI_CGAP_Lu5
Homo sapiens cDNA clone IMAGE: Homo sapiens 41,738 9-Jun-98 1500491
3' similar to gb: X69908_rna1 ATP SYNTHASE LIPID-BINDING PROTEIN P2
PRECURSOR (HUMAN);, mRNA sequence. rxa02552 918 GB_GSS9: AQ129371
377 AQ129371 HS_3045_A2_B07_MR CIT Approved Human Genomic Sperm
Library D Homo sapiens 42,857 23-Sep-98 Homo sapiens genomic clone
Plate = 3045 Col = 14 Row = C, genomic survey sequence. GB_GSS14:
AQ566979 600 AQ566979 HS_2105_A2_D12_MR CIT Approved Human Genomic
Sperm Library D Homo sapiens 35,443 29-MAY-1999 Homo sapiens
genomic clone Plate = 2105 Col = 24 Row = G, genomic survey
sequence. GB_IN1: MEPAP 4636 X54422 M. edulis gene for polyphenolic
adhesive protein. Mytilus edulis 35,619 27-MAY-1992 rxa02554 747
GB_PR4: AC004882 171878 AC004882 Homo sapiens PAC clone DJ076B20
from 22, complele sequence. Homo sapiens 37,346 22-OCT-1999 GB_PR4:
AC004882 171878 AC004882 Homo sapiens PAC clone DJ076B20 from 22,
complete sequence. Homo sapiens 38,44 22-OCT-1999 GB_BA2: U32830
16388 U32830 Haemophilus influenzae Rd section 145 of 163 of the
complete genome. Haemophilus influenzae Rd 33,514 29-MAY-1998
rxa02555 726 GB_GSS1: FR0020618 466 AL013501 F. rubripes GSS
sequence, clone 042H13bD8, genomic survey sequence. Fugu rubripes
40,215 10-DEC-1997 GB_GSS1: FR0020576 555 AL013459 F. rubripes GSS
sequence, clone 042H13aE5, genomic survey sequence. Fugu rubripes
35,379 10-DEC-1997 GB_GSS1: FR0020585 431 AL013468 F. rubripes GSS
sequence, clone 042H13aH5, genomic survey sequence. Fugu rubripes
39,718 10-DEC-1997 rxa02564 1125 GB_PR3: AC004976 127425 AC004976
Homo sapiens PAC clone DJ1143H19 from 7p14-p15, complete sequence.
Homo sapiens 37,364 5-Nov-98 GB_PR2: HUAC002038 161973 AC002038
Homo sapiens chromosome 2 clone 101B6 map 2p11, complete sequence.
Homo sapiens 36,404 30-Jun-97 GB_HTG3: AC010791 111643 AC010791
Homo sapiens chromosome 17 clone 6_M_14 map 17, *** SEQUENCING Homo
sapiens 34,293 22-Sep-99 IN PROGRESS ***, 8 unordered pieces.
rxa02568 1753 GB_BA1: FT16SRNAA 1521 Z21931 F. tularensis 16S rRNA.
Francisella tularensis 39,065 5-Jun-97 GB_BA1: FT16SRNAB 1520
Z21932 F. tularensis 16S rRNA. Francisella tularensis 37,807
16-DEC-1997 GB_BA1: FP16SRNAA 1518 Z21933 F. philomiragia 16S rRNA.
Francisella philomiragia 36,38 5-Jun-97 rxa02569 873 GB_GSS13:
AQ469518 553 AQ469518 CITBI-E1-2596J20.TR CITBI-E1 Homo sapiens
genomic clone 2596J20, genomic Homo sapiens 39,201 23-Apr-99 survey
sequence. GB_GSS12: AQ403903 495 AQ403903 HS_5058_B1_F07_T7A
RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 36,049
13-MAR-1999 genomic clone Plate = 634 Col = 13 Row = L, genomic
survey sequence. GB_PR2: AF004715 2889 AF004715 Homo sapiens jerky
gene product homolog mRNA, complete cds. Homo sapiens 35,689
6-Aug-97 rxa02570 765 GB_BA1: CGU43535 2531 U43535 Corynebacterium
glutamicum multidrug resistance protein (cmr) gene, complete cds.
Corynebacterium 38,165 9-Apr-97 glutamicum GB_EST33: AI776398 499
AI776398 EST257498 tomato resistant, Cornell Lycopersicon
esculentum cDNA clone Lycopersicon esculentum 42,084 29-Jun-99
cLER18I10, mRNA sequence. GB_EST23: AI119807 431 AI119807
uc21a06.r1 Soares mouse mammary gland NbMMG Mus musculus cDNA clone
Mus musculus 40,281 2-Sep-98 IMAGE: 1398610 5', mRNA sequence.
rxa02573 rxa02575 1258 GB_BA1: SCGD3 33779 AL096822 Streptomyces
coelicolor cosmid GD3. Streptomyces coelicolor 39,742 8-Jul-99
GB_RO: AC002108 41125 AC002108 Genomic sequence from Mouse 4,
complete sequence. Mus musculus 36,1 29-MAY-1997 GB_PR1: HUMIDS
36845 L35485 Homo sapiens iduronate sulphate sulphatase (IDS) gene,
complete cds. Homo sapiens 34,183 16-Aug-94 rxa02576 1545 GB_GSS15:
AQ618143 582 AQ618143 HS_5168_B1_H08_T7A RPCI-11 Human Male BAC
Library Homo sapiens Homo sapiens 34,874 15-Jun-99 genomic clone
Plate = 744 Col = 15 Row = P, genomic survey sequence. GB_OV:
XLFB1A1 2172 X64759 X. laevis mRNA for transcription factor (clone
XLFB1a1). Xenopus laevis 38,589 26-Jan-93 GB_PR4: AC005039 151316
AC005039 Homo sapiens clone NH0512E16, complete sequence. Homo
sapiens 33,575 14-Jan-99 rxa02577 1008 GB_PL2: AF034976 7130
AF034976 Pilayella littoralis ribosomal protein S14 (rps14) gene,
partial cds; ATPase subunit Mitochondrion Pilayella 34,69 22-Jun-98
8 (atp8) gene, complete cds; tRNA-Ser gene, complete sequence;
ribosomal littoralis protein S10 (rps10) and ribosomal protein L31
(rpl31) genes, complete cds; tRNA-Ser gene, complete sequence;
T7-like RNA polymerase (rpox) gene, complete cds; and unknown
genes, mitochondrial genes for mitochondrial products. GB_EST30:
AI655188 456 AI655188 wb67g02.x1 NCI_CGAP_GC6 Homo sapiens cDNA
clone IMAGE: 2310770 3', Homo sapiens 39,198 04-MAY-1999 mRNA
sequence. GB_PL2: AF034976 7130 AF034976 Pilayella littoralis
ribosomal protein S14 (rps14) gene, partial cds; ATPase subunit
Mitochondrion Pilayella 39,959 22-Jun-98 8 (atp8) gene, complete
cds; tRNA-Ser gene, complete sequence; ribosomal protein littoralis
S10 (rps10) and ribosomal protein L31 (rpl31) genes, complete cds;
tRNA-Ser gene, complete sequence; T7-like RNA polymerase (rpox)
gene, complete cds;
and unknown genes, mitochondrial genes for mitochondrial products.
rxa02584 474 GB_PR2: AP000191 100000 AP000191 Homo sapiens genomic
DNA, chromosome 21q22.1, D21S226-AML region, Homo sapiens 37,199
20-Nov-99 clone Q78C10-f32E9, segment 18/21, complete sequence.
GB_EST13: AA349881 293 AA349881 EST56832 infant brain Homo sapiens
cDNA 5' end similar to EST containing Homo sapiens 42,466 21-Apr-97
Alu repeat, mRNA sequence. GB_EST23: AI078215 404 AI078215
oz12h12.x1 Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens cDNA
clone Homo sapiens 48,78 29-Sep-98 IMAGE: 1675175 3'similar to
contains Alu repetitive etement; contains element THR repetitive,
element;, mRNA sequence. rxa02585 1104 GB_PR2: AP000115 100000
AP000115 Homo sapiens genomic DNA of 21q22.1, GART and AML related,
Q78C10-149C3 Homo sapiens 35,502 25-Sep-99 region, segment 18/20,
complete sequence. GB_PR2: AP000191 100000 AP000191 Homo sapiens
genomic DNA, chromosome 21q22.1, D21S226-AML region, clone Homo
sapiens 35,502 20-Nov-99 Q78C10-f32E9, segment 18/21, complete
sequence. GB_PR2: AP000047 50188 AP000047 Homo sapiens genomic DNA,
chromosome 21q22.1, segment 18/28, Homo sapiens 35,502 20-Nov-99
complete sequence. rxa02588 807 GB_BA1: MTCY8D5 39730 Z92669
Mycobacterium tuberculosis H37Rv complete genome; segment 12/162.
Mycobacterium 38,354 18-Jun-98 tuberculosis GB_BA1: MTCY349 43523
Z83018 Mycobacterium tuberculosis H37Rv complete genome; segment
131/162. Mycobacterium 39,949 17-Jun-98 tuberculosis GB_HTG2:
AC007879 158841 AC007879 Homo sapiens clone NH0309L06, ***
SEQUENCING IN PROGRESS ***, Homo sapiens 36,835 31-Jul-99 2
unordered pieces. rxa02591 1953 GB_BA1: MTCY8D5 39730 Z92669
Mycobacterium tuberculosis H37Rv complete genome; segment 12/162.
Mycobacterium 65,398 18-Jun-98 tuberculosis GB_BA1: MLCL622 42498
Z95398 Mycobacterium leprae cosmid L622. Mycobacterium leprae
63,875 24-Jun-97 GB_BA1: CHBATP2OP 5477 L08777 Chlorobium limicola
atp2 operon. Chlorobium limicola 37,979 26-Apr-93 rxa02593 720
GB_GSS1: CNS0056G 994 AL057090 Drosophila melanogaster genome
survey sequence T7 end of BAC # BACR11M23 Drosophila melanogaster
27,206 3-Jun-99 of RPCI-98 library from Drosophila melanogaster
(fruit fly), genomic survey sequence. GB_GSS1: CNS0056G 994
AL057090 Drosophila melanogaster genome survey sequence T7 end of
BAC # BACR11M23 Drosophila melanogaster 30,27 3-Jun-99 of RPCI-98
library from Drosophila melanogaster (fruit fly), genomic survey
sequence. rxa02598 714 GB_IN1: PFMAL3P5 86829 AL034556 Plasmodium
falciparum MAL3P5, complete sequence. Plasmodium falciparum 40,057
04-OCT-1999 GB_PL1: AB024026 23026 AB024026 Arabidopsis thaliana
genomic DNA, chromosome 5, TAC clone: K15O15, Arabidopsis thaliana
38,865 20-Nov-99 complete sequence. GB_BA2: AE000930 15553 AE000930
Methanobacterium thermoautotrophicum from bases 1592014 to 1607566
Methanobacterium 36,804 15-Nov-97 (section 136 of 148) of the
complete genome. thermoautotrophicum rxa02600 1521 GB_IN2: AC004301
68620 AC004301 Drosophila melanogaster DNA sequence (P1 DS07134
(D192)), complete sequence. Drosophila melanogaster 36,063
29-MAY-1998 GB_PL2: AC007504 125021 AC007504 Arabidopsis thaliana
chromosome I BAC F13F21 genomic sequence, Arabidopsis thaliana
37,074 9-Jul-99 complete sequence. GB_PH: AF125520 61670 AF125520
Bacteriophage 933W, complete genome. Bacteriophage 933W 35,396
16-Apr-99 rxa02601 2112 GB_BA1: MTV026 23740 AL022076 Mycobacterium
tuberculosis H37Rv complete genome; segment 157/162. Mycobacterium
38,676 24-Jun-99 tuberculosis GB_BA2: SSU73128 2331 U73128
Sphingomonas sp. A8AN3 catechol 2,3-dioxygenase gene, complete cds
and Sphingomonas sp. A8AN3 40,02 1-Feb-99 2-hydroxymuconic
semialdehyde hydrolase and 2-hydroxymuconic semialdehyde
dehydrogenase genes, partial cds. GB_BA2: SSU73128 2331 U73128
Sphingomonas sp. A8AN3 catechol 2,3-dioxygenase gene, complete cds
and Sphingomonas sp. A8AN3 40,101 1-Feb-99 2-hydroxymuconic
semialdehyde hydrolase and 2-hydroxymuconic semialdehyde
dehydrogenase genes, partial cds. rxa02602 627 GB_PR3: AF006751
3106 AF006751 Homo sapiens ES/130 mRNA, complete cds. Homo sapiens
37,582 10-Jul-98 GB_PR3: AF006751 3106 AF006751 Homo sapiens ES/130
mRNA, complete cds. Homo sapiens 38,462 10-Jul-98 GB_GSS9: AQ090116
404 AQ090116 HS_3000_B1_E09_MF CIT Approved Human Genomic Sperm
Library D Homo sapiens 39,481 26-Aug-98 Homo sapiens genomic clone
Plate = 3000 Col = 17 Row = J, genomic survey sequence. rxa02604
2199 GB_PL1: CREHIH3G 4358 L41841 Chlamydomonas reinhardtii histone
H3, histone H4, histone H2B, and histone H2A Chlamydomonas
reinhardtii 37,5 16-MAY-1996 genes, complete cds. GB_GSS13:
AQ455681 621 AQ455681 HS_5068_B1_E01_T7A RPCI-11 Human Male BAC
Library Homo Homo sapiens 36,246 21-Apr-99 sapiens genomic clone
Plate = 644 Col = 1 Row = J, genomic survey sequence. GB_GSS6:
AQ829471 392 AQ829471 HS_5442_A2_F11_SP6E RPCI-11 Human Male BAC
Library Homo Homo sapiens 42,347 27-Aug-99 sapiens genomic clone
Plate = 1018 Col = 22 Row = K, genomic survey sequence. rxa02606
1494 GB_PAT: A26027 2547 A26027 C. melassecola gene for
extracellular antigen PS1. Corynebacterium 42,857 2-Apr-95
melassecola GB_BA1: CGCOP1G 2547 X66078 C. glutamicum cop1 gene for
PS1. Corynebacterium 42,857 30-Jun-93 glutamicum GB_PR2: AP000134
100000 AP000134 Homo sapiens genomic DNA of 21q22.1, GART and AML,
f43D11-119B8 region, Homo sapiens 36,145 25-Sep-99 segment 9/10,
complete sequence. rxa02609 372 GB_HTG3: AC009212 125452 AC009212
Drosophila melanogaster chromosome 3 clone BACR01A18 (D669) RPCI-98
01.A.18 Drosophila melanogaster 35,753 23-Aug-99 map 82E-82F strain
y; cn bw sp, *** SEQUENCING IN PROGRESS***, 119 unordered pieces.
GB_HTG3: AC009212 125452 AC009212 Drosophila melanogaster
chromosome 3 clone BACR01A18 (D669) RPCI-98 01.A.18 Drosophila
melanogaster 35,753 23-Aug-99 map 82E-82F strain y; cn bw sp, ***
SEQUENCING IN PROGRESS***, 119 unordered pieces. GB_HTG2: AC007589
134659 AC007589 Drosophila melanogaster chromosome 3 clone
BACR20D10 (D667) RPCI-98 20.D.10 Drosophila melanogaster 35,484
2-Aug-99 map 82D-82E strain y; cn bw sp, *** SEQUENCING IN PROGRESS
***, 73 unordered pieces. rxa02610 1050 GB_BA2: AF073776 5138
AF073776 Pseudomonas aeruginosa MexZ (mexZ), complete cds; and
mexGH operon, Pseudomonas aeruginosa 38,323 19-OCT-1998 complete
sequence. GB_BA1: AB015853 5461 AB015853 Pseudomonas aeruginosa
gene for MexX and MexY, complete cds. Pseudomonas aeruginosa 38,447
13-Nov-98 GB_VI: HIM237805 2400 AJ237805 Human immunodeficiency
virus type 1 partial envelope gene (gp160), isolate MP255. Human
immunodeficiency 37,928 15-Jun-99 virus type 1 rxa02617 630 GB_PR2:
HSL81781 4041 L81781 Homo sapiens (subclone 7_e4 from P1 H25) DNA
sequence, complete sequence. Homo sapiens 38,835 9-Apr-97 GB_HTG3:
AC011430 106902 AC011430 Homo sapiens chromosome 5 clone P1_660D11,
*** SEQUENCING IN Homo sapiens 38,662 06-OCT-1999 PROGRESS ***, 28
unordered pieces. GB_HTG3: AC011430 106902 AC011430 Homo sapiens
chromosome 5 clone P1_660D11, *** SEQUENCING IN Homo sapiens 38,662
06-OCT-1999 PROGRESS ***, 28 unordered pieces. rxa02619 1023
GB_BA1: CGL133719 1839 AJ133719 Corynebacterium glutamicum yjcc
gene, amtR gene and citE gene, partial. Corynebacterium 100
12-Aug-99 glutamicum GB_BA1: CGL133719 1839 AJ133719
Corynebacterium glutamicum yjcc gene, amtR gene and citE gene,
partial. Corynebacterium 100 12-Aug-99 glutamicum GB_EST18:
AA734344 378 AA734344 vv24f02.r1 Stratagene mouse heart (#937316)
Mus musculus cDNA clone Mus musculus 37,968 7-Jan-98 IMAGE: 1223355
5', mRNA sequence. rxa02620 789 GB_BA1: CGL133719 1839 AJ133719
Corynebacterium glutamicum yjcc gene, atmR gene and citE gene,
partial. Corynebacterium 100 12-Aug-99 glutamicum GB_BA1: CGL133719
1839 AJ133719 Corynebacterium glutamicum yjcc gene, amtR gene and
citE gene, partial. Corynebacterium 100 12-Aug-99 glutamicum
GB_EST16: C27457 252 C27457 C27457 Rice callus cDNA Oryza sativa
cDNA clone C51917_1A, mRNA sequence. Oryza sativa 39,044 6-Aug-97
rxa02624 1419 GB_HTG2: AC005995 170023 AC005995 Homo sapiens clone
DJ0042M02, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,533
23-Apr-99 13 unordered pieces. GB_HTG2: AC005995 170023 AC005995
Homo sapiens clone DJ0042M02, *** SEQUENCING IN PROGRESS ***, Homo
sapiens 38,533 23-Apr-99 13 unordered pieces. GB_PR4: AC004895
152927 AC004895 Homo sapiens clone DJ0810E06, complete sequence.
Homo sapiens 38,533 29-MAY-1999 rxa02639 957 GB_BA1: MSGY409 41321
AD000017 Mycobacterium tuberculosis sequence from clone y409.
Mycobacterium 50,37 10-DEC-1998 tuberculosis GB_BA1: MTCY409 30352
Z97188 Mycobacterium tuberculosis H37Rv complete genome; segment
158/162. Mycobacterium 38,039 17-Jun-98 tuberculosis GB_HTG2:
AC006765 274498 AC006765 Caenorhabditis elegans clone Y43H11, ***
SEQUENCING IN PROGRESS***, Caenorhabditis elegans 35,225 23-Feb-99
7 unordered pieces. rxa02647 585 GB_PAT: A45577 1925 A45577
Sequence 1 from Patent WO9519442. Corynebacterium 37,545
07-MAR-1997 glutamicum GB_PAT: A45579 1925 A45579 Sequence 3 from
Patent WO9519442. Corynebacterium 37,545 07-MAR-1997 glutamicum
GB_PAT: A45581 1925 A45581 Sequence 5 from Patent WO9519442.
Corynebacterium 37,545 07-MAR-1997 glutamicum rxa02649 1125 GB_BA1:
D90904 150894 D90904 Synechocystis sp. PCC6803 complete genome,
6/27, 630555-781448. Synechocystis sp. 37,772 7-Feb-99 GB_PR3:
HS941F9 127587 Z95331 Human DNA sequence from BAC 941F9 on
chromosome 22q11.2-qter. Homo sapiens 38,748 23-Nov-99 Contains
ESTs, STSs and 3' part of FIBULIN-1 D PRECURSOR like gene, part of
a Brain Protein E46 like gene and a CpG island, complete sequence.
GB_BA1: D90904 150894 D90904 Synechocystis sp. PCC6803 complete
genome, 6/27, 630555-781448. Synechocystis sp. 36,364 7-Feb-99
rxa02652 702 GB_BA2: AF048749 24454 AF048749 Bacteroides fragilis
capsular polysaccharide biosynthesis Bacteroides fragilis 37,464
25-Jun-99 operon, complete sequence. GB_HTG4: AC009244 318775
AC009244 Homo sapiens chromosome 7, *** SEQUENCING IN PROGRESS ***,
Homo sapiens 35,447 26-OCT-1999 36 unordered pieces. GB_HTG4:
AC009244 318775 AC009244 Homo sapiens chromosome 7, *** SEQUENCING
IN PROGRESS ***, Homo sapiens 35,447 26-OCT-1999 36 unordered
pieces. rxa02655 1107 GB_EST10: AA185699 290 AA185699 mt62d11.r1
Soares 2NbMT Mus musculus cDNA clone IMAGE: Mus musculus 39,51
19-Feb-97 634485 5' similar to TR: G300372 G300372 CELL GROWTH
REGULATING NUCLEOLAR PROTEIN.;, mRNA sequence. GB_GSS13: AQ429764
439 AQ429764 HS_5079_A2_C12_SP6E RPCI-11 Human Male BAC Library
Homo sapiens 37,701 31-MAR-1999 Homo sapiens genomic clone Plate =
655 Col = 24 Row = E, genomic survey sequence. GB_GSS8: AQ012380
646 AQ012380 CIT-HSP-2300L9.TF CIT-HSP Homo sapiens genomic clone
2300L9, Homo sapiens 38,874 6-Jun-98 genomic survey sequence.
rxa02662 387 GB_HTG2: AC007802 118569 AC007802 Drosophila
melanogaster chromosome 2 clone BACR07I11 (D648) RPCI-98 Drosophila
melanogaster 37,696 2-Aug-99 07.1.11 map 58A1-58A2 strain y; cn bw
sp, *** SEQUENCING IN PROGRESS ***, 70 unordered pieces. GB_HTG2:
AC007802 118569 AC007802 Drosophila melanogaster chromosome 2 clone
BACR07I11 (D648) Drosophila melanogaster 37,696 2-Aug-99 RPCI-98
07.I.11 map 58A1-58A2 strain y; cn bw sp, *** SEQUENCING IN
PROGRESS ***, 70 unordered pieces. GB_HTG2: AC007802 118569
AC007802 Drosophila melanogaster chromosome 2 clone BACR07I11
(D648) Drosophila melanogaster 35,616 2-Aug-99 RPCI-98 07.I.11 map
58A1-58A2 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 70
unordered pieces. rxa02665 603 GB_HTG1: AC002419 128340 AC002419
Homo sapiens chromosome X clone bWXD40, *** SEQUENCING Homo sapiens
32,941 12-Aug-97 IN PROGRESS***, 2 unordered pieces. GB_HTG1:
AC002419 128340 AC002419 Homo sapiens chromosome X clone bWXD40,
*** SEQUENCING Homo sapiens 32,941 12-Aug-97 IN PROGRESS ***, 2
unordered pieces. GB_GSS15: AQ655091 630 AQ655091 Sheared
DNA-21B5.TF Sheared DNA Trypanosoma brucel Trypanosoma brucel
41,794 22-Jun-99 genomic clone Sheared DNA-21B5, genomic survey
sequence. rxa02670 705 GB_HTG2: AC006450 177555 AC006450 Homo
sapiens chromosome 9 clone hRPK.85_O_21 map 9, Homo sapiens 41,374
15-Jul-99 *** SEQUENCING IN PROGRESS ***, 2 ordered pieces.
GB_HTG2: AC006450 177555 AC006450 Homo sapiens chromosome 9 clone
hRPK.85_O_21 map 9, Homo sapiens 41,374 15-Jul-99 *** SEQUENCING IN
PROGRESS ***, 2 ordered pieces. GB_BA1: SPU86147 2268 U86147
Synechococcus PCC7942 UDP-N-acetylmuramate-alanine ligase (murC)
Synechococcus PCC7942 40,177 15-Feb-97 gene, partial cds, UDP-N-
acetylenolpyruvylglucosamine reductase (murB), and mercuric
resistance operon regulatory protein (merR) genes, complete cds.
rxa02672 1221 GB_BA1: MTV024 8189 AL022075 Mycobacterium
tuberculosis H37Rv complete Mycobacterium 53,197 17-Jun-98 genome;
segment 151/162. tuberculosis GB_BA1: MSGY23 40806 AD000016
Mycobacterium tuberculosis Mycobacterium 37,5 10-DEC-1996 sequence
from clone y23. tuberculosis GB_EST38: AW029724 634 AW029724
EST272979 tomato callus, TAMU Lycopersicon esculentum cDNA
Lycopersicon esculentum 40 15-Sep-99 clone cLEC28I17 similar to
beta- ketoacyl-ACP synthase, putative, mRNA sequence. rxa02673 756
GB_GSS12: AQ356661 518 AQ356661 CITBI-E1-2531G11.TF CITBI-E1 Homo
sapiens genomic Homo sapiens 33,022 24-Jan-99 clone 2531G11,
genomic survey sequence. GB_IN1: CELC50A2 36582 AF036689
Caenorhabditis elegans cosmid C50A2. Caenorhabditis elegans 35,443
05-DEC-1997 GB_HTG2: AC006702 299864 AC006702 Caenorhabditis
elegans clone Y104H12b, *** SEQUENCING Caenorhabditis elegans
35,443 23-Feb-99 IN PROGRESS ***, 3 unordered pieces. rxa02678 1041
GB_HTG1: AP000452 83103 AP000452 Homo sapiens chromosome 11 clone
PAC2 map 11q11, Homo sapiens 35,098 13-Sep-99 *** SEQUENCING IN
PROGRESS ***, in unordered pieces. GB_HTG1: AP000452 83103 AP000452
Homo sepiens chromosome 11 clone PAC2 map 11q11, Homo sapiens
35,098 13-Sep-99 *** SEQUENCING IN PROGRESS ***, in unordered
pieces. GB_PR3: HS498I24 58190 AL031057 Human DNA sequence from
clone 498I24 on chromosome 6p22.1-22.3 Homo sapiens 35,328
23-Nov-99 Contains STS, GSS and a CpG island, complete sequence.
rxa02680 1407 GB_BA1: MLCB268 38859 AL022602 Mycobacterium leprae
cosmid B268. Mycobacterium leprae 37,797 27-Aug-99 GB_BA1:
MSGB1554CS 36548 L78814 Mycobacterium leprae cosmid B1554 DNA
sequence. Mycobacterium leprae 36,9 15-Jun-96 GB_BA1: MSGB1551CS
36548 L78813 Mycobacterium leprae cosmid B1551 DNA sequence.
Mycobacterium leprae 36,9 15-Jun-96 rxa02683 rxa02685 780 GB_HTG3:
AC008640 198483 AC008640 Homo sapiens chromosome 5 clone
CIT978SKB_17P2, Homo sapiens 37,299 3-Aug-99 *** SEQUENCING IN
PROGRESS ***, 70 unordered pieces. GB_HTG3: AC008640 198483
AC008640 Homo sapiens chromosome 5 clone CIT978SKB_17P2, Homo
sapiens 37,299 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 70
unordered pieces. GB_BA2: AE000945 11317 AE000945 Archaeoglobus
fulgidus section 162 of 172 Archaeoglobus fulgidus 38,76
15-DEC-1997 of the complete genome. rxa02688 792 GB_BA1: CORPHEA
1088 M13774 C. glutamicum pheA gene encoding prephenate
Corynebacterium 100 26-Apr-93 dehydratase, complete cds. glutamicum
GB_HTG2: AC007554 167095 AC007554 Homo sapiens clone hRPK.74_A_1,
Homo sapiens 35,226 14-MAY-1999 *** SEQUENCING IN PROGRESS ***, 10
unordered pieces. GB_HTG2: AC007554 167095 AC007554 Homo sapiens
clone hRPK.74_A_1, Homo sapiens 35,226 14-MAY-1999 *** SEQUENCING
IN PROGRESS ***, 10 unordered pieces. rxa02689 465 GB_GSS9:
AQ110873 414 AQ110873 CIT-HSP-2378K10.TR CIT-HSP Homo sapiens
genomic Homo sapiens 34,768 29-Aug-98 clone 2378K10, genomic survey
sequence. GB_OV: DUKFASA 9138 M21635 Duck (A. platyrhynchos) S-acyl
fatty acid synthase Anas platyrhynchos 39,177 28-Apr-93
thioesterase gene, complete cds. GB_OV: DUKFASA 9138 M21635 Duck
(A. platyrhynchos) S-acyl fatty acid synthase Anas platyrhynchos
35,022 28-Apr-93 thioesterase gene, complete cds. rxa02690 1221
GB_HTG4: AC010096 223607 AC010096 Homo sapiens chromosome unknown
clone NH0364A16, Homo sapiens 39,301 29-OCT-1999 WORKING DRAFT
SEQUENCE, in unordered pieces. GB_HTG4: AC010096 223607 AC010096
Homo sapiens chromosome unknown clone NH0364A16, Homo sapiens
39,301 29-OCT-1999 WORKING DRAFT SEQUENCE, in unordered pieces.
GB_BA2: AF132788 1411 AF132788 Fischerella muscicola small subunit
ribosomal RNA gene, Fischerella muscicola 36,156 1-Sep-99 partial
sequence. rxa02693 1899 GB_GSS5: AQ784372 542 AQ784372
HS_3181_A2_H12_T7C CIT Approved Human Genomic Sperm Library Homo
sapiens 41,546 3-Aug-99 D Homo sapiens genomic clone Plate = 3181
Col = 24 Row = O, genomic survey sequence. GB_HTG4: AC010573 80511
AC010573 Drosophila melanogaster chromosome 3L/70C12 clone
RPCI98-2M13, Drosophila melanogaster 36,839 16-OCT-1999 ***
SEQUENCING IN PROGRESS ***, 45 unordered pieces. GB_EST18: AA696238
640 AA696238 GM05354.5prime GM Drosophila melanogaster ovary
BlueScript Drosophila melanogaster 39,523 28-Nov-98 Drosophila
melanogaster cDNA clone GM05354 5prime, mRNA sequence. rxa02696 579
GB_BA1: AB003132 4116 AB003132 Corynebacterium glutamicum gene for
Corynebacterium 100 4-Aug-97 MurC, FtsQ, FtsZ, complete cds.
glutamicum GB_PR4: AC006024 90583 AC006024 Homo sapiens PAC clone
DJ1166G19 from 7p12-p11.2, Homo sapiens 36,049 20-Feb-99 complete
sequence. GB_HTG1: HSJ657D12 315458 AL109943 Homo sapiens
chromosome X clone RP4-657D12 map q22.1-24, Homo sapiens 36,475
24-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces.
rxa02697 1650 GB_EST20: AA874010 365 AA874010 vw87b05.r1 Stratagene
mouse skin (#937313) Mus musculus cDNA Mus musculus 39,452
19-MAR-1998 clone IMAGE: 1261905 5', mRNA sequence. GB_EST30:
AI658486 599 AI658486 tu17a09.x1 NCI_CGAP_Pr28 Homo sapiens cDNA
clone IMAGE: Homo sapiens 37,324 10-MAY-1999 2251288 3', mRNA
sequence. GB_EST20: AA874010 365 AA874010 vw87b05.r1 Stratagene
mouse skin (#937313) Mus musculus Mus musculus 39,452 19-MAR-1998
cDNA clone IMAGE: 1261905 5', mRNA sequence. rxa02700 1359 GB_BA1:
SCF85 21420 AL110470 Streptomyces coelicolor cosmid F85.
Streptomyces coelicolor 39,497 1-Sep-99 A3(2) GB_HTG5: AC011629
69344 AC011629 Homo sapiens chromosome 15 clone 334_M_8 map 15,
Homo sapiens 37,462 13-Nov-99 LOW-PASS SEQUENCE SAMPLING. GB_HTG3:
AC010106 157581 AC010106 Homo sapiens clone NH0575J05, Homo sapiens
36,22 11-Sep-99 *** SEQUENCING IN PROGRESS ***, 1 unordered pieces.
rxa02701 1431 GB_BA1: MTCI65 34331 Z95584 Mycobacterium
tuberculosis H37Rv Mycobacterium 41,867 17-Jun-98 complete genome;
segment 50/162. tuberculosis GB_BA1: MSGY348 40056 AD000020
Mycobacterium tuberculosis Mycobacterium 43,338 10-DEC-1996
sequence from clone y348. tuberculosis GB_PR2: AP000117 151516
AP000117 Homo sapiens genomic DNA of 21q22.1, GART and AML related,
Homo sapiens 36,037 25-Sep-99 Q78C10-149C3 region, segment 20/20,
complete sequence. rxa02712 918 GB_BA2: AF124600 4115 AF124600
Corynebacterium glutamicum chorismate synthase (aroC),
Corynebacterium 37,294 04-MAY-1999 shikimate kinase (aroK), and 3-
glutamicum dehydroquinate synthase (aroB) genes, complete cds: and
putative cytoplasmic peptidase (pepQ) gene, partial cds. GB_BA2:
AF053071 1083 AF053071 Corynebacterium glutamicum dehydroquinate
synthetase Corynebacterium 39,675 12-Sep-98 (aroB) gene, complete
cds; glutamicum GB_BA1: BSTHRZ 19861 Z80360 B. subtilis thrZ
downstream chromosomal region. Bacillus subtilis 34,002 24-Jun-98
rxa02714 552 GB_PL2: ATF9F13 109936 AL080253 Arabidopsis thaliana
DNA chromosome 4, BAC clone F9F13 (ESSA project). Arabidopsis
thaliana 39,252 16-Aug-99 GB_PL2: ATT29H11 87011 AL049659
Arabidopsis thaliana DNA chromosome 3, BAC clone T29H11.
Arabidopsis thaliana 34,249 9-Jun-99 GB_EST4: H37460 489 H37460
15589 Lambda-PRL2 Arabidopsis thaliana Arabidopsis thaliana 45,869
30-DEC-1997 cDNA clone 181N17T7, mRNA sequence. rxa02715 513
GB_GSS13: AQ454067 534 AQ454067 HS_5176_B1_A09_T7A RPCI-11 Homo
sapiens 40,854 21-Apr-99 Human Male BAC Library Homo sapiens
genomic clone Plate = 752 Col = 17 Row = B, genomic survey
sequence. GB_PR3: AC005495 185254 AC005495 Homo sapiens chromosome
17, clone hRPK.293_K_20, complete sequence. Homo sapiens 33,2
30-OCT-1998 GB_PR3: AC005495 185254 AC005495 Homo sapiens
chromosome 17, clone hRPK.293_K_20, complete sequence. Homo sapiens
36,273 30-OCT-1998 rxa02720 825 GB_BA1: AB003132 4116 AB003132
Corynebacterium glutamicum gene for MurC, FtsQ, FtsZ, complete cds.
Corynebacterium 98,788 4-Aug-97 glutamicum GB_BA1: BLFTSZ 5546
Y08964 B. lactofermentum murC, ftsQ or divD & ftsZ genes.
Corynebacterium 100 08-OCT-1998 glutamicum GB_HTG4: AC009764 213581
AC009764 Homo sapiens chromosome 11 clone 381_O_22 map 11, Homo
sapiens 35,504 21-OCT-1999 *** SEQUENCING IN PROGRESS ***, 40
unordered pieces. rxa02721 861 GB_BA1: BLFTSZ 5546 Y08964 B.
lactofermentum murC, ftsQ or Corynebacterium 98,606 08-OCT-1998
divD & ftsZ genes. glutamicum GB_BA1: AB003132 4116 AB003132
Corynebacterium glutamicum gene for MurC, FtsQ, FtsZ, complete cds.
Corynebacterium 97,561 4-Aug-97 glutamicum GB_BA1: SCI51 40745
AL109848 Strepomyces coelicolor cosmid I5t. Streptomyces coelicolor
39,11 16-Aug-99 A3(2) rxa02725 735 GB_BA1: CGU43535 2531 U43535
Corynebacterium glutamicum multidrug resistance protein (cmr) gene,
complete cds. Corynebacterium 42,043 9-Apr-97 glutamicum GB_EST1:
D40448 361 D40448 RICS2437A Rice shoot Oryza sativa cDNA, mRNA
sequence. Oryza sativa 41,944 11-Nov-94 GB_BA2: AF030430 8330
AF038430 Thiobacillus neapolitanus carboxysome operon, complete
sequence. Thiobacillus neapolitanus 39,202 21-Aug-98 rxa02727 1035
GB_BA1: MTCY270 37586 Z95388 Mycobacterium tuberculosis H37Rv
complete genome; segment 96/162. Mycobacterium 37,427 10-Feb-99
tuberculosis GB_BA1: MTAG84 1458 X77129 M. tuberculosis Ag84 (CIE)
gene. Mycobacterium 49,339 21-Jul-95 tuberculosis GB_BA1: AP000064
247695 AP000064 Aeropyrum pernix genomic DNA, section 7/7.
Aeropyrum pernix 38,79 22-Jun-99 rxa02735 828 GB_BA1: TVCPT 1923
X56901 T. vulgaris cpT gene for carboxypeptidase T.
Thermoactinomyces 37,688 30-OCT-1991 vulgaris GB_GSS4: AQ682162 355
AQ682162 HS_5503_B2_C11_SP6E RPCI-11 Human Homo sapiens 35,294
28-Jun-99 Male BAC Library Homo sapiens genomic clone Plate = 1079
Col = 22 Row = F. genomic survey sequence. GB_EST21: AA915356 456
AA915356 vz29a08.r1 Soares 2NbMT Mus musculus cDNA clone IMAGE: Mus
musculus 42,609 14-Apr-98 1327862 5', mRNA sequence. rxa02736 1080
GB_PAT: E13655 2260 E13655 gDNA encoding glucose-6-phosphate
dehydrogenase. Corynebacterium 99,62 24-Jun-98 glutamicum GB_GSS13:
AQ447106 711 AQ447106 mgxb0004P18f CUGI Rice Blast BAC Library
Magnaporthe Magnaporthe grisea 38,158 8-Apr-99 grisea genomic clone
mgxb0004P18f, genomic survey sequence. GB_EST36: AI900850 670
AI900850 sb95c03.y1 Gm-c1012 Glycine max cDNA clone GENOME SYSTEMS
Glycine max 37,479 08-DEC-1999 CLONE ID: Gm-c1012-413 5' similar to
SW: IF4Z_TOBAC Q40468 EUKARYOTIC INITIATION FACTOR 4A-15;, mRNA
sequence. rxa02744 927 GB_PR1: AB026898 270000 AB026898 Homo
sapiens DNA, DLEC1 to ORCTL4 gene region, Homo sapiens 39,364
15-MAY-1999 section 1/2 (DLEC1, ORCTL3, ORCTL4 genes, complete
cds). GB_PR1: AB026898 270000 AB026898 Homo sapiens DNA, DLEC1 to
ORCTL4 gene region, Homo sapiens 36,275 15-MAY-1999 section 1/2
(DLEC1, ORCTL3, ORCTL4 genes, complete cds). GB_PR2: AP000498
100000 AP000498 Homo sapiens genomic DNA, chromosome 3p21.3, clone:
603 to Homo sapiens 39,364 28-Sep-99 320, anti-oncogene region,
section 1/3. rxa02751 597 GB_HTG4: AC010127 189552 AC010127 Homo
sapiens chromosome unknown clone Homo sapiens 36,149 29-OCT-1999
NH0002I08, WORKING DRAFT SEQUENCE, in unordered pieces. GB_HTG4:
AC010127 189552 AC010127 Homo sapiens chromosome unknown clone Homo
sapiens 36,149 29-OCT-1999 NH0002I08, WORKING DRAFT SEQUENCE, in
unordered pieces. GB_HTG4: AC010127 189552 AC010127 Homo sapiens
chromosome unknown clone Homo sapiens 35,924 29-OCT-1999 NH0002I08,
WORKING DRAFT SEQUENCE, in unordered pieces. rxa02756 1014 GB_RO:
CRUGIPR 2785 D38103 Hamster mRNA for GIP (gastric inhibitory
Cricetulus sp. 38,501 8-Feb-99 polypeptide) receptor, complete cds.
GB_HTG1: CNS01DRV 224372 AL118558 Homo sapiens chromosome 14 clone
R-1017G21, Homo sapiens 38,667 15-OCT-1999 *** SEQUENCING IN
PROGRESS ***, in unordered pieces. GB_HTG1: CNS01DRV 224372
AL118558 Homo sapiens chromosome 14 clone R-1017G21, Homo sapiens
38,667 15-OCT-1999 *** SEQUENCING IN PROGRESS ***, in unordered
pieces. rxa02757 669 GB_RO: RNU35245 2051 U35245 Rat vacuolar
protein sorting
Rattus norvegicus 39,058 15-Jan-97 homolog r-vps33b mRNA, complete
cds. GB_RO: RNU35245 2051 U35245 Rat vacuolar protein sorting
homolog Rattus norvegicus 37,481 15-Jan-97 r-vps33b mRNA, complete
cds. rxa02765 882 GB_EST4: H46883 459 H46883 yo19f06.r1 Soares
adult brain N2b5NB55Y Homo sapiens cDNA Homo sapiens 40,132
31-Jul-95 clone IMAGE: 178403 5', mRNA sequence. GB_PL1: NTA6235
3931 AJ006235 Nicotiana tabacum DNA fragment for K-alpha right
T-DNA border. Nicotiana tabacum 34,247 6-Feb-99 GB_HTG3: AC011519
57287 AC011519 Homo sapiens chromosome 19 clone LLNL-F_192H5, Homo
sapiens 38,497 07-OCT-1999 *** SEQUENCING IN PROGRESS ***, 36
unordered pieces. rxa02766 516 GB_GSS13: AQ489419 554 AQ489419
RPCI-11-246A3.TV RPCI-11 Homo sapiens genomic clone Homo sapiens
37,821 24-Apr-99 RPCI-11-246A3, genomic survey sequence. GB_PR3:
HS90L6 190837 Z97353 Human DNA sequence from clone 90L6 on
chromosome 22q11.21-11.23. Homo sapiens 38,16 23-Nov-99 Contains an
RPL15 (60S Ribosomal Protein L15) pseudogene, ESTs. STSs and GSSs,
complete sequence. GB_BA1: MTCY373 35516 Z73419 Mycobacterium
tuberculosis H37Rv complete genome; segment 57/162. Mycobacterium
36,701 17-Jun-98 tuberculosis rxa02770 1689 GB_BA2: AF038651 4077
AF038651 Corynebacterium glutamicum dipeptide-binding protein
Corynebacterium 100 14-Sep-98 (dciAE) gene, partial cds; adenine
phosphoribosyltransferase (apt) and GTP pyrophosphokinase (rel)
genes, complete cds; and glutamicum unknown gene. GB_OV: AF061275
6756 AF061275 Ictalurus punctatus estrogen receptor type alpha
mRNA, complete cds. Ictaturus punctatus 37,117 31-OCT-1998 GB_RO:
MMSCSELN4 3840 X61756 M. musculus rearranged T-cell receptor beta
variable region (Vb17a). Mus musculus 37,933 03-DEC-1991 rxa02774
494 GB_HTG2: AF129408 138685 AF129408 Homo sapiens chromosome 21
clone PAC 31K18 map 21q22.3, Homo sapiens 38,241 04-MAR-1999 ***
SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: AF129408
138685 AF129408 Homo sapiens chromosome 21 clone PAC 31K18 map
21q22.3, Homo sapiens 38,241 04-MAR-1999 *** SEQUENCING IN PROGRESS
***, in unordered pieces. GB_PR3: AF064859 122571 AF064859 Homo
sapiens chromosome 21q22.3 PAC 141B3, complete sequence, Homo
sapiens 37,91 2-Jun-98 containing ribosomal protein homologue
pseudogene L23a. rxa02775 348 GB_PR3: HSU19F10 31474 Z81145 Human
DNA sequence from cosmid U19F10, Homo sapiens 36,443 23-Nov-99
between markers DXS366 and DXS87 on chromosome X contains ESTs.
GB_EST11: AA211850 293 AA211850 zr90e04.s1 NCI_CGAP_GCB1 Homo
sapiens cDNA clone Homo sapiens 30,479 13-Aug-97 IMAGE: 682974 3'
similar to TR: G1224065 G1224065 MER37 TRANSPOSABLE ELEMENT,
COMPLETE CONSENSUS SEQUENCE.;, mRNA sequence. GB_EST13: AA372532
400 AA372532 EST84441 Colon adenocarcinoma IV Homo sapiens Homo
sapiens 40,104 21-Apr-97 cDNA 5' end, mRNA sequence. rxa02776 465
GB_GSS9: AQ096114 383 AQ096114 HS_3030_A2_D11_MF CIT Approved Human
Genomic Homo sapiens 44,643 27-Aug-98 Sperm Library D Homo sapiens
genomic clone Plate = 3030 Col = 22 Row = G, genomic survey
sequence. GB_RO: AF139518 8827 AF139518 Rattus norvegicus A-kinase
anchor protein mRNA, complete cds. Rattus norvegicus 39,722
16-Jun-99 GB_EST32: AI728295 564 AI728295 BNLGHi10386 Six-day
Cotton fiber Gossypium hirsutum cDNA Gossypium hirsutum 37,049
11-Jun-99 5' similar to (AF076274) contains similarity to rat p47
protein (GB: AB002086) [Arabidopsis thaliana], mRNA sequence.
rxa02777 1230 GB_HTG3: AC009407 207973 AC009407 Homo sapiens clone
NH0223I10, Homo sapiens 39,784 21-Aug-99 *** SEQUENCING IN PROGRESS
***, 16 unordered pieces. GB_HTG3: AC009407 207973 AC009407 Homo
sapiens clone NH0223I10, Homo sapiens 39,784 21-Aug-99 ***
SEQUENCING IN PROGRESS ***, 16 unordered pieces. GB_BA2: AE001137
44380 AE001137 Borrelia burgdorferi (section 23 of 70) of the
complete genome. Borrelia burgdorferi 39,105 15-DEC-1997 rxa02778
348 GB_EST37: AI940900 668 AI940900 sb79d08.y1 Gm-c1010 Glycine max
cDNA clone Glycine max 35,036 3-Aug-99 GENOME SYSTEMS CLONE ID:
Gm-c1010-1192 5' similar to SW: ITRA_SOYBN P01070 TRYPSIN
INHIBITORS A AND C PRECURSOR;, mRNA sequence. GB_HTG4: AC008940
131864 AC008940 Homo sapiens chromosome 5 clone CITB-H1_2319M24,
Homo sapiens 33,043 31-OCT-1999 *** SEQUENCING IN PROGRESS ***, 3
ordered pieces. GB_HTG4: AC008940 131864 AC008940 Homo sapiens
chromosome 5 clone CITB-H1_2319M24, Homo sapiens 33,043 31-OCT-1999
*** SEQUENCING IN PROGRESS ***, 3 ordered pieces. rxa02779 402
GB_PR1: AB020876 100000 AB020876 Homo sapiens genomic DNA of 9q32
anti-oncogene of Homo sapiens 35 21-MAY-1999 flat epitherium
cancer, segment 8/10. GB_EST26: AI339126 415 AI339126 qt06d03.x1
NCI_CGAP_GC4 Homo sapiens cDNA clone IMAGE: Homo sapiens 35,876
29-DEC-1998 1946789 3' similar to gb: L25444 60S RIBOSOMAL PROTEIN
L35A (HUMAN);, mRNA sequence. GB_PR1: AB020876 100000 AB020876 Homo
sapiens genomic DNA of 9q32 anti-oncogene of Homo sapiens 35,678
21-MAY-1999 flat epitherium cancer, segment 8/10. rxa02780 450
GB_GSS14: AQ524732 591 AQ524732 HS_5236_A1_D09_SP6E RPCI-11 Human
Male BAC Homo sapiens 39,726 11-MAY-1999 Library Homo sapiens
genomic clone Plate = 812 Col = 17 Row = G, genomic survey
sequence. GB_PR4: AC006051 38903 AC006051 Homo sapiens 12p13.3 PAC
RPCI5-1103G8 (Roswell Homo sapiens 35,068 26-Nov-98 Park Cancer
Institute Human PAC Library) complete sequence. GB_PR4: AC006051
38903 AC006051 Homo sapiens 12p13.3 PAC RPCI5-1103G8 (Roswell Homo
sapiens 37,273 26-Nov-98 Park Cancer Institute Human PAC Library)
complete sequence. rxa02781 1314 GB_VI: BHV1CGEN 135301 AJ004801
Bovine herpesvirus 1 complete genome. Bovine herpesvirus type
41,053 11-Jan-99 1.1 GB_BA1: SHGCPIR 107379 X86780 S. hygroscopicus
gene cluster for Streptomyces 40,551 16-Aug-96 polyketide
immunosuppressant rapamycin. hygroscopicus GB_BA1: SHGCPIR 107379
X86780 S. hygroscopicus gene cluster for Streptomyces 39,598
16-Aug-96 polyketide immunosuppressant rapamycin. hygroscopicus
rxa02782 1422 GB_IN1: DSV28T23 5218 X60176 D. silvestris clone
U28T2 non-LTR retrotransposon DNA (5218 bp). Drosophila silvestris
38,695 25-MAR-1992 GB_IN1: DSV28T24 7779 X60177 D. silvestris clone
U28T2 non-LTR retrotransposon DNA (7779 bp). Drosophila silvestris
38,844 30-Nov-93 GB_BA2: MPU34795 24888 U34795 Mycoplasma
pneumoniae cosmid pcosMPGT9 25 kb EcoRI fragment. Mycoplasma
pneumoniae 37,832 06-MAR-1996 rxa02783 672 GB_EST2: R13483 481
R13483 yf77g03.r1 Soares Infant brain 1NIB Homo sapiens cDNA clone
Homo sapiens 36,243 12-Apr-95 IMAGE: 28494 5', mRNA sequence.
GB_HTG3: AC011333 159160 AC011333 Homo sapiens chromosome 5 clone
CIT-HSPC_229L21, Homo sapiens 38,246 06-OCT-1999 *** SEQUENCING IN
PROGRESS ***, 23 unordered pieces. GB_HTG3: AC011333 159160
AC011333 Homo sapiens chromosome 5 clone CIT-HSPC_229L21, Homo
sapiens 38,246 06-OCT-1999 *** SEQUENCING IN PROGRESS ***, 23
unordered pieces. rxa02784 309 GB_PR3: HS474A14 107352 AL023285
Human DNA sequence from clone 474A14 on chromosome 1q24.1-25.2 Homo
sapiens 37,868 23-Nov-99 Contains EST, CA repeat, 5'UTR
(tenascin-R), GSS, complete sequence. GB_GSS12: AQ374565 441
AQ374565 RPCI11-159P12.TV RPCI.11 Homo sapiens genomic clone
RPCI-11-159P12, Homo sapiens 36,522 20-MAY-1999 genomic survey
sequence. GB_GSS5: AQ780184 686 AQ780184 HS_3138_B1_F11_MR CIT
Approved Human Genomic Sperm Homo sapiens 44,186 2-Aug-99 Library D
Homo sapiens genomic clone Plate = 3138 Col = 21 Row = L, genomic
survey sequence. rxa02786 830 GB_PL1: SCYBL033C 1794 Z35794 S.
cerevisiae chromosome II reading frame ORF YBL033c. Saccharomyces
cerevisiae 39,264 11-MAR-1998 GB_PL1: ECRIB1GN 1747 Z21617 S.
cerevisiae RIB1 gene encoding GTP cyclohydrolase II. Saccharomyces
cerevisiae 37,118 28-Jan-95 GB_PAT: A38763 1747 A38763 Sequence 1
from Patent WO9411515. Saccharomyces cerevisiae 37,118 05-MAR-1997
rxa02789 669 GB_EST34: AV146372 295 AV146372 AV146372 Mus musculus
C57BL/6J 10-11 day Mus musculus 65,432 3-Jul-99 embryo Mus musculus
cDNA clone 2810453K19, mRNA sequence. GB_GSS5: AQ785226 524
AQ785226 HS_2025_B2_A07_T7C CIT Approved Human Genomic Homo sapiens
40,342 3-Aug-99 Sperm Library D Homo sapiens genomic clone Plate =
2025 Col = 14 Row = B, genomic survey sequence. GB_BA1: SCE94 38532
AL049628 Streptomyces coelicolor cosmid E94. Streptomyces
coelicolor 35,346 12-Apr-99 rxa02793 825 GB_HTG2: AC006514 247029
AC006514 Homo sapiens clone RPCI11-656E20, Homo sapiens 33,742
1-Apr-99 *** SEQUENCING IN PROGRESS ***, 90 unordered pieces.
GB_HTG2: AC006514 247029 AC006514 Homo sapiens clone RPCI11-656E20,
Homo sapiens 33,742 1-Apr-99 *** SEQUENCING IN PROGRESS ***, 90
unordered pieces. GB_EST22: AI033150 384 AI033150 ow94b01.s1
Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens 38,951 28-Aug-98
Homo sapiens cDNA clone IMAGE: 1654441 3' similar to TR: O02711
O02711 PRO-POL-DUTPASE POLYPROTEIN;, mRNA sequence. rxa02796 672
GB_OV: AF172144 1101 AF172144 Xenopus laevis potassium channel beta
2 subunit mRNA, partial cds. Xenopus laevis 40 25-Sep-99 GB_HTG1:
AP000572 84439 AP000572 Homo sapiens chromosome 11 clone P28D2 map
11q13, Homo sapiens 35,725 09-OCT-1999 *** SEQUENCING IN PROGRESS
***, in unordered pieces. GB_HTG1: AP000572 84439 AP000572 Homo
sapiens chromosome 11 clone P28D2 map 11q13, Homo sapiens 35,725
09-OCT-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces.
rxa02798 1548 GB_EST10: AA155097 322 AA155097 mr24h12.r1 Soares
mouse 3NbMS Mus musculus cDNA clone Mus musculus 41,195 16-Feb-97
IMAGE: 598439 5', mRNA sequence. GB_GSS9: AQ150317 489 AQ150317
HS_3178_B1_F12_T7 CIT Approved Human Genomic Sperm Homo sapiens
39,549 08-OCT-1998 Library D Homo sapiens genomic clone Plate =
3178 Col = 23 Row = L, genomic survey sequence. GB_BA2: AE001731
10186 AE001731 Thermotoga maritima section 43 of 136 of the
complete genome. Thermotoga maritima 35,747 2-Jun-99 rxa02799 396
GB_IN2: AF139876 1562 AF139876 Giardia intestinalis histone H4
gene, complete cds. Giardia intestinalis 34,848 02-OCT-1999
GB_HTG5: AC011614 176606 AC011614 Drosophila melanogaster
chromosome X clone BACR48L05 (D1142) Drosophila melanogaster 38,817
19-Nov-99 RPCI-98 48.L.5 map 16F-17A strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 114 unordered pieces. GB_GSS10:
AQ254726 565 AQ254726 EP(3)3517 Drosophila melanogaster EP line
Drosophila melanogaster Drosophila melanogaster 38,798 28-Jun-99
genomic Sequence recovered from Both 5' and 3' ends of P element,
genomic survey sequence. rxa02812 rxa02815 552 GB_BA2: PAU32853
1961 U32853 Pseudomonas aeruginosa mucC and mucD genes, complete
cds. Pseudomonas aeruginosa 39,925 06-MAR-1996 GB_BA2: PAU49151
4587 U49151 Pseudomonas aeruginosa alternate sigma factor (algU),
Pseudomonas aeruginosa 39,925 13-MAR-1996 mucA, mucB, mucC and mucD
genes, complete cds. GB_BA2: PAU49151 4587 U49151 Pseudomonas
aeruginosa alternate sigma factor (algU), Pseudomonas aeruginosa
35,922 13-MAR-1996 mucA, mucB, mucC and mucD genes, complete cds.
rxa02817 499 GB_BA1: CORAIA 4705 L09232 Corynebacterium glutamicum
acetohydroxy acid synthase (ilvB) and Corynebacterium 38,554
23-Feb-95 (ilvN) genes, and acetohydroxy glutamicum acid
isomeroreductase (ilvC) gene, complete cds. GB_EST22: AI004214 475
AI004214 ot94h01.x1 Soares_total_fetus_Nb2HF8_9w Homo sapiens
51,092 27-Aug-98 Homo sapiens cDNA clone IMAGE: 1624465 3', mRNA
sequence. GB_EST27: AI457904 455 AI457904 tj48b08.x1
Soares_NSF_F8_9W_OT_PA_P_S1 Homo sapiens 37,381 13-Apr-99 Homo
sapiens cDNA clone IMAGE: 2144727 3', mRNA sequence. rxa02818 606
GB_PL1: MZEADH1CM 6167 M32984 Z. mays alcohol dehydrogenase (ADH-1
C-m allele) gene, complete cds. Zea mays 33,111 27-Apr-93 GB_PL1:
ZMADH1ALL 6158 X17556 Z. mays DNA for Adh1-Cm allele. Zea mays
33,111 23-Jan-92 GB_PL1: MZEADN1CM 6167 M32984 Z. mays alcohol
dehydrogenase (ADH-1 C-m allele) gene, complete cds. Zea mays
38,065 27-Apr-93 rxa02823 370 GB_PL2: AF077130 4392 AF077130 Oryza
sativa receptor-like protein kinase gene, complete cds. Oryza
sativa 33,243 25-Jul-98 GB_HTG1: CNS00M8S 214599 AL079302 Homo
sapiens chromosome 14 clone R-1089B7, Homo sapiens 38,42
15-OCT-1999 *** SEQUENCING IN PROGRESS ***, in ordered pieces.
GB_HTG1: CNS00M8S 214599 AL079302 Homo sapiens chromosome 14 clone
R-1089B7, Homo sapiens 38,42 15-OCT-1999 *** SEQUENCING IN PROGRESS
***, in ordered pieces. rxa02825 1962 GB_PL1: ZMU17350 1289 U17350
Zea mays thiamine biosynthetic enzyme (thi1-1) mRNA, complete cds.
Zea mays 40,71 12-Apr-96 GB_GSS13: AQ440082 432 AQ440082
HS_5080_B1_B12_SP6E RPCI-11 Human Homo sapiens 41,121
31-MAR-1999
Male BAC Library Home sapiens genomic clone Plate = 656 Col = 23
Row = D, genomic survey sequence. GB_EST10: AA141278 579 AA141278
CK01542.3prime CK Drosophila melanogaster embryo Drosophila
melanogaster 42,424 29-Nov-98 BlueScript Drosophila melanogaster
cDNA clone CK01542 3prime, mRNA sequence. rxa02827 523 GB_BA2:
AF054624 6984 AF054624 Lactobacillus sakel transcription-repair
coupling factor Lactobacillus sakel 37,241 12-Jan-99 (mfd) gene,
partial cds; L-lactate dehydrogenase (ldhL) gene, complete cds; and
unknown genes. GB_BA2: AF023181 6616 AF023181 Listeria
monocytogenes transcription-repair coupling factor Listeria
monocytogenes 61,228 1-Jan-99 (mfdL), low temperature requirement B
protein (ltrB), and DivlC homolog (divL) genes, complete cds.
GB_HTG3: AC009213 114735 AC009213 Drosophila melanogaster
chromosome 3 clone BACR09F18 (D812) Drosophila melanogaster 32,427
23-Aug-99 RPCI-98 09.F.18 map 98D-98D strain y; cn bw sp, ***
SEQUENCING IN PROGRESS ***, 109 unordered pieces. rxa02838 528
GB_BA2: AE000069 12230 AE000069 Rhizobium sp. NGR234 plasmid
pNGR234a, section 6 of 46 Rhizobium sp. NGR234 57,803 12-DEC-1997
of the complete plasmid sequence. GB_OM: SSU19994 2004 U19994 Sus
scrofa p55 TNF receptor mRNA, complete cds. Sus scrofa 34,848
30-Jan-96 GB_BA2: AE000069 12230 AE000069 Rhizobium sp. NGR234
plasmid pNGR234a, section 6 of 46 of the Rhizoblum sp. NGR234
36,505 12-DEC-1997 complete plasmid sequence. rxa02840 273 GB_BA2:
ECU73857 128824 U73857 Escherichia coli chromosome minutes 6-8.
Escherichia coli 100 14-Jul-99 GB_BA2: AE000145 11448 AE000145
Escherichia coli K-12 MG1655 section 35 of 400 of the complete
genome. Escherichia coli 100 12-Nov-98 GB_BA1: ECORFABC 3044 X76979
E. coli orf302, 0rf303 and orf101 sequence. Escherichia coli 40,672
28-Aug-96 rxa02841 558 GB_GSS4: AQ724171 407 AQ724171
HS_5380_B1_H09_SP6E RPCI-11 Human Male BAC Library Homo sapiens
35,135 14-Jul-99 Homo sapiens genomic clone Plate = 956 Col = 17
Row = P. genomic survey sequence. GB_PL1: PSFERR 1023 X64417 P.
sativum mRNA for ferritin. Pisum sativum 41,985 30-Jun-93 GB_PL1:
PSFERRI 1023 X73369 P. sativum mRNA for ferritin. Pisum sativum
41,985 21-Jul-95 rxa02842 365 GB_EST32: AI723928 435 AI723928
RHIZ1_35_B10.y1_A001 Rhizome1 Sorghum halepense 32,616 11-Jun-99
Sorghum halepense cDNA, mRNA sequence. GB_PR2: HS212A2 212753
Z95114 Human DNA sequence from clone 212A2 on chromosome Homo
sapiens 38,279 23-Nov-99 22q12 Contains gene for TNF-inducible
protein CG12-1. 3' end of a gene similar to apolipoprotein L, ESTs,
STSs, CA repeat, GSSs and CpG islands, complete sequence. GB_OV:
AF116856 4634 AF116856 Gallus gallus neurocan core protein
precursor, mRNA, complete cds. Gallus gallus 41,176 20-MAY-1999
rxa02845 615 GB_PR3: AC005934 43699 AC005934 Homo sapiens
chromosome 19, cosmid R30813, complete sequence. Homo sapiens
35,225 5-Nov-98 GB_PR3: AC005340 36705 AC005340 Homo sapiens
chromosome 19, cosmid F19544, complete sequence. Homo sapiens
35,225 30-Jul-98 GB_PR3: AC005934 43699 AC005934 Homo sapiens
chromosome 19, cosmid R30813, complete sequence. Homo sapiens
39,163 5-Nov-98 rxa02846 873 GB_GSS5: AQ749564 838 AQ749564
HS_5575_A1_B11_SP6 RPCI-11 Human Male Homo sapiens 36,286 19-Jul-99
BAC Library Homo sapiens genomic clone Plate = 1151 Col = 21 Row =
C, genomic survey sequence. GB_GSS5: AQ749564 838 AQ749564
HS_5575_A1_B11_SP6 RPCI-11 Human Male BAC Homo sapiens 38,591
19-Jul-99 Library Homo sapiens genomic clone Plate = 1151 Col = 21
Row = C, genomic survey sequence. rxa02847 1135 GB_BA1: MSGB13GS
42923 L78823 Mycobacterium leprae cosmid B13 DNA sequence.
Mycobacterium leprae 47,559 15-Jun-96 GB_HTG4: AC009557 128590
AC009557 Homo sapiens chromosome 15 clone 76_D_16 map 15, Homo
sapiens 36,289 25-OCT-1999 LOW-PASS SEQUENCE SAMPLING. GB_HTG4:
AC009557 128590 AC009557 Homo sapiens chromosome 15 clone 76_D_16
map 15, Homo sapiens 36,289 25-OCT-1999 LOW-PASS SEQUENCE SAMPLING.
rxa02848 499 GB_BA1: AB018531 4961 AB018531 Corynebacterium
glutamicum dtsR1 and dtsR2 genes, complete cds. Corynebacterium
98,397 19-OCT-1998 glutamicum GB_PAT: E17019 4961 E17019
Brevibacterium lactofermentum dtsR and dtsR2 genes. Corynebacterium
98,397 28-Jul-99 glutamicum GB_OM: CFU08596 1780 U08596 Canis
familiaris delayed rectifier K+ channel mRNA, partial cds. Canis
familiaris 43,265 21-DEC-1994 rxa02849 305 GB_VI: AF121950 9395
AF121950 Hepatitis G virus strain lowan, complete genome. Hepatitis
G virus 33,11 24-MAY-1999 GB_PAT: AR049304 9327 AR049304 Sequence
234 from patent US 5824507. Unknown. 31,803 29-Sep-99 GB_PAT:
AR026878 9327 AR026878 Sequence 234 from patent US 5856134.
Unknown. 31,803 29-Sep-99
[0169] TABLE-US-00002 TABLE 3 Corynebacterium and Brevibacterium
Strains Which May be Used in the Practice of the Invention Genus
species ATCC FERM NRRL CECT NCIMB CBS NCTC DSMZ Brevibacterium
ammoniagenes 21054 Brevibacterium ammoniagenes 19350 Brevibacterium
ammoniagenes 19351 Brevibacterium ammoniagenes 19352 Brevibacterium
ammoniagenes 19353 Brevibacterium ammoniagenes 19354 Brevibacterium
ammoniagenes 19355 Brevibacterium ammoniagenes 19356 Brevibacterium
ammoniagenes 21055 Brevibacterium ammoniagenes 21077 Brevibacterium
ammoniagenes 21553 Brevibacterium ammoniagenes 21580 Brevibacterium
ammoniagenes 39101 Brevibacterium butanicum 21196 Brevibacterium
divaricatum 21792 P928 Brevibacterium flavum 21474 Brevibacterium
flavum 21129 Brevibacterium flavum 21518 Brevibacterium flavum
B11474 Brevibacterium flavum B11472 Brevibacterium flavum 21127
Brevibacterium flavum 21128 Brevibacterium flavum 21427
Brevibacterium flavum 21475 Brevibacterium flavum 21517
Brevibacterium flavum 21528 Brevibacterium flavum 21529
Brevibacterium flavum B11477 Brevibacterium flavum B11478
Brevibacterium flavum 21127 Brevibacterium flavum B11474
Brevibacterium healii 15527 Brevibacterium ketoglutamicum 21004
Brevibacterium ketoglutamicum 21089 Brevibacterium ketosoreductum
21914 Brevibacterium lactofermentum 70 Brevibacterium
lactofermentum 74 Brevibacterium lactofermentum 77 Brevibacterium
lactofermentum 21798 Brevibacterium lactofermentum 21799
Brevibacterium lactofermentum 21800 Brevibacterium lactofermentum
21801 Brevibacterium lactofermentum B11470 Brevibacterium
lactofermentum B11471 Brevibacterium lactofermentum 21086
Brevibacterium lactofermentum 21420 Brevibacterium lactofermentum
21086 Brevibacterium lactofermentum 31269 Brevibacterium linens
9174 Brevibacterium linens 19391 Brevibacterium linens 8377
Brevibacterium paraffinolyticum 11160 Brevibacterium spec. 717.73
Brevibacterium spec. 717.73 Brevibacterium spec. 14604
Brevibacterium spec. 21860 Brevibacterium spec. 21864
Brevibacterium spec. 21865 Brevibacterium spec. 21866
Brevibacterium spec. 19240 Corynebacterium acetoacidophilum 21476
Corynebacterium acetoacidophilum 13870 Corynebacterium
acetoglutamicum B11473 Corynebacterium acetoglutamicum B11475
Corynebacterium acetoglutamicum 15806 Corynebacterium
acetoglutamicum 21491 Corynebacterium acetoglutamicum 31270
Corynebacterium acetophilum B3671 Corynebacterium ammoniagenes 6872
2399 Corynebacterium ammoniagenes 15511 Corynebacterium fujiokense
21496 Corynebacterium glutamicum 14067 Corynebacterium glutamicum
39137 Corynebacterium glutamicum 21254 Corynebacterium glutamicum
21255 Corynebacterium glutamicum 31830 Corynebacterium glutamicum
13032 Corynebacterium glutamicum 14305 Corynebacterium glutamicum
15455 Corynebacterium glutamicum 13058 Corynebacterium glutamicum
13059 Corynebacterium glutamicum 13060 Corynebacterium glutamicum
21492 Corynebacterium glutamicum 21513 Corynebacterium glutamicum
21526 Corynebacterium glutamicum 21543 Corynebacterium glutamicum
13287 Corynebacterium glutamicum 21851 Corynebacterium glutamicum
21253 Corynebacterium glutamicum 21514 Corynebacterium glutamicum
21516 Corynebacterium glutamicum 21299 Corynebacterium glutamicum
21300 Corynebacterium glutamicum 39684 Corynebacterium glutamicum
21488 Corynebacterium glutamicum 21649 Corynebacterium glutamicum
21650 Corynebacterium glutamicum 19223 Corynebacterium glutamicum
13869 Corynebacterium glutamicum 21157 Corynebacterium glutamicum
21158 Corynebacterium glutamicum 21159 Corynebacterium glutamicum
21355 Corynebacterium glutamicum 31808 Corynebacterium glutamicum
21674 Corynebacterium glutamicum 21562 Corynebacterium glutamicum
21563 Corynebacterium glutamicum 21564 Corynebacterium glutamicum
21565 Corynebacterium glutamicum 21566 Corynebacterium glutamicum
21567 Corynebacterium glutamicum 21568 Corynebacterium glutamicum
21569 Corynebacterium glutamicum 21570 Corynebacterium glutamicum
21571 Corynebacterium glutamicum 21572 Corynebacterium glutamicum
21573 Corynebacterium glutamicum 21579 Corynebacterium glutamicum
19049 Corynebacterium glutamicum 19050 Corynebacterium glutamicum
19051 Corynebacterium glutamicum 19052 Corynebacterium glutamicum
19053 Corynebacterium glutamicum 19054 Corynebacterium glutamicum
19055 Corynebacterium glutamicum 19056 Corynebacterium glutamicum
19057 Corynebacterium glutamicum 19058 Corynebacterium glutamicum
19059 Corynebacterium glutamicum 19060 Corynebacterium glutamicum
19185 Corynebacterium glutamicum 13286 Corynebacterium glutamicum
21515 Corynebacterium glutamicum 21527 Corynebacterium glutamicum
21544 Corynebacterium glutamicum 21492 Corynebacterium glutamicum
B8183 Corynebacterium glutamicum B8182 Corynebacterium glutamicum
B12416 Corynebacterium glutamicum B12417 Corynebacterium glutamicum
B12418 Corynebacterium glutamicum B11476 Corynebacterium glutamicum
21608 Corynebacterium lilium P973 Corynebacterium nitrilophilus
21419 11594 Corynebacterium spec. P4445 Corynebacterium spec. P4446
Corynebacterium spec. 31088 Corynebacterium spec. 31089
Corynebacterium spec. 31090 Corynebacterium spec. 31090
Corynebacterium spec. 31090 Corynebacterium spec. 15954 20145
Corynebacterium spec. 21857 Corynebacterium spec. 21862
Corynebacterium spec. 21863 ATCC: American Type Culture Collection,
Rockville, MD, USA FERM: Fermentation Research Institute, Chiba,
Japan NRRL: ARS Culture Collection, Northern Regional Research
Laboratory, Peoria, IL, USA CECT: Coleccion Espanola de Cultivos
Tipo, Valencia, Spain NCIMB: National Collection of Industrial and
Marine Bacteria Ltd., Aberdeen, UK CBS: Centraalbureau voor
Schimmelcultures, Baarn, NL NCTC: National Collection of Type
Cultures, London, UK DSMZ: Deutsche Sammlung von Mikroorganismen
und Zellkulturen, Braunschweig, Germany For reference see Sugawara,
H. et al. (1993) World directory of collections of cultures of
microorganisms: Bacteria, fungi and yeasts (4.sup.th edn), World
federation for culture collections world data center on
microorganisms, Saimata, Japen.
[0170] TABLE-US-00003 TABLE 2 GENES IDENTIFIED FROM GENBANK GenBank
.TM. Accession No. Gene Name Gene Function Reference A09073 ppg
Phosphoenol pyruvate carboxylase Bachmann, B. et al. "DNA fragment
coding for phosphoenolpyruvat corboxylase, recombinant DNA carrying
said fragment, strains carrying the recombinant DNA and method for
producing L-aminino acids using said strains," Patent: EP 0358940-A
3 Mar. 21, 1990 A45579, Threonine dehydratase Moeckel, B. et al.
"Production of L-isoleucine by means of recombinant A45581,
micro-organisms with deregulated threonine dehydratase," Patent: WO
9519442-A 5 Jul. 20, 1995 A45583, A45585 A45587 AB003132 murC;
ftsQ; ftsZ Kobayashi, M. et al. "Cloning, sequencing, and
characterization of the ftsZ gene from coryneform bacteria,"
Biochem. Biophys. Res. Commun., 236(2): 383-388 (1997) AB015023
murC; ftsQ; Wachi, M. et al. "A murC gene from Coryneform
bacteria," Appl. Microbiol. Biotechnol., 51(2): 223-228 (1999)
AB018530 dtsR Kimura, E. et al. "Molecular cloning of a novel gene,
dtsR, which rescues the detergent sensitivity of a mutant derived
from Brevibacterium lactofermentum," Biosci. Biotechnol. Biochem.,
60(10): 1565-1570 (1996) AB018531 dtsR1; dtsR2 AB020624 murI
D-glutamate racemase AB023377 tkt transketolase AB024708 gltB; gltD
Glutamine 2-oxoglutarate aminotransferase large and small subunits
AB025424 acn aconitase AB027714 rep Replication protein AB027715
rep; aad Replication protein; aminoglycoside adenyltransferase
AF005242 argC N-acetylglutamate-5-semialdehyde dehydrogenase
AF005635 glnA Glutamine synthetase AF030405 hisF cyclase AF030520
argG Argininosuccinate synthetase AF031518 argF Ornithine
carbamolytransferase AF036932 aroD 3-dehydroquinate dehydratase
AF038548 pyc Pyruvate carboxylase AF038651 dciAE;. apt; rel
Dipeptide-binding protein; adenine Wehmeier, L. et al. "The role of
the Corynebacterium glutamicum rel gene in
phosphoribosyltransferase; GTP (p)ppGpp metabolism," Microbiology,
144: 1853-1862 (1998) pyrophosphokinase AF041436 argR Arginine
repressor AF045998 impA Inositol monophosphate phosphatase AF048764
argH Argininosuccinate lyase AF049897 argC; argJ; argB;
N-acetylglutamylphosphate reductase; argD; argF; argR; ornithine
acetyltransferase; N- argG; argH acetylglutamate kinase;
acetylornithine transminase; ornithine carbamoyltransferase;
arginine repressor; argininosuccinate synthase; argininosuccinate
lyase AF050109 inhA Enoyl-acyl carrier protein reductase AF050166
hisG ATP phosphoribosyltransferase AF051846 hisA
Phosphoribosylformimino-5-amino-1-
phosphoribosyl-4-imidazolecarboxamide isomerase AF052652 metA
Homoserine O-acetyltransferase Park, S. et al. "Isolation and
analysis of metA, a methionine biosynthetic gene encoding
homoserine acetyltransferase in Corynebacterium glutamicum," Mol.
Cells., 8(3): 286-294 (1998) AF053071 aroB Dehydroquinate
synthetase AF060558 hisH Glutamine amidotransferase AF086704 hisE
Phosphoribosyl-ATP- pyrophosphohydrolase AF114233 aroA
5-enolpyruvylshikimate 3-phosphate synthase AF116184 panD
L-aspartate-alpha-decarboxylase precursor Dusch, N. et al.
"Expression of the Corynebacterium glutamicum panD gene encoding
L-aspartate-alpha-decarboxylase leads to pantothenate
overproduction in Escherichia coli," Appl. Environ. Microbiol.,
65(4)1530-1539 (1999) AF124518 aroD; aroE 3-dehydroquinase;
shikimate dehydrogenase AF124600 aroC; aroK; aroB; Chorismate
synthase; shikimate kinase; 3- pepQ dehydroquinate synthase;
putative cytoplasmic peptidase AF145897 inhA AF145898 inhA AJ001436
ectP Transport of ectoine, glycine betaine, Peter, H. et al.
"Corynebacterium glutamicum is equipped with four secondary proline
carriers for compatible solutes: Identification, sequencing, and
characterization of the proline/ ectoine uptake system, ProP, and
the ectoine/proline/glycine betaine carrier, EctP," J. Bacteriol.,
180(22): 6005-6012 (1998) AJ004934 dapD Tetrahydrodipicolinate
succinylase Wehrmann, A. et al. "Different modes of diaminopimelate
synthesis and their (incomplete.sup.i) role in cell wall integrity:
A study with Corynebacterium glutamicum," J. Bacteriol., 180(12):
3159-3165 (1998) AJ007732 ppc; secG; amt; ocd;
Phosphoenolpyruvate-carboxylase; ?; high soxA affinity ammonium
uptake protein; putative ornithine-cyclodecarboxylase; sarcosine
oxidase AJ010319 ftsY, glnB, glnD; srp; Involved in cell division;
PII protein; Jakoby, M. et al. "Nitrogen regulation in
Corynebacterium glutamicum; amtP uridylyltransferase
(uridylyl-removing Isolation of genes involved in biochemical
characterization of corresponding enzmye); signal recognition
particle; low proteins," FEMS Microbial., 173(2): 303-310 (1999)
affinity ammonium uptake protein AJ132968 cat Chloramphenicol
aceteyl transferase AJ224946 mqo L-malate: quinone oxidoreductase
Molenaar, D. et al. "Biochemical and genetic characterization of
the membrane-associated malate dehydrogenase (acceptor) from
Corynebacterium glutamicum," Eur. J. Biochem., 254(2): 395-403
(1998) J238250 ndh NADH dehydrogenase AJ238703 porA Porin
Lichtinger, T. et al. "Biochemical and biophysical characterization
of the cell wall porin of Corynebacterium glutamicum: The channel
is formed by a low molecular mass polypeptide," Biochemistry,
37(43): 15024-15032 (1998) D17429 Transposable element IS31831
Vertes, A. A. et al. "Isolation and characterization of IS31831, a
transposable element from Corynebacterium glutamicum," Mol.
Microbiol., 11(4): 739-746 (1994) D84102 odhA 2-oxoglutarate
dehydrogenase Usuda, Y. et al. "Molecular cloning of the
Corynebacterium glutamicum (Brevibacterium lactofermentum AJ12036)
odhA gene encoding a novel type of 2-oxoglutarate dehydrogenase,"
Microbiology, 142: 3347-3354 (1996) E01358 hdh; hk Homoserine
dehydrogenase; homoserine Katsumata, R. et al. "Production of
L-thereonine and L-isoleucine," Patent: JP 1987232392-A 1 Oct. 12,
1987 kinase E01359 Upstream of the start codon of homoserine
Katsumata, R. et al. "Production of L-thereonine and L-isoleucine,"
Patent: JP kinase gene 1987232392-A 2 Oct. 12, 1987 E01375
Tryptophan operon E01376 trpL; trpE Leader peptide; anthranilate
synthase Matsui, K. et al. "Tryptophan operon, peptide and protein
coded thereby, utilization of tryptophan operon gene expression and
production of tryptophan," Patent: JP 1987244382-A 1 Oct. 24, 1987
E01377 Promoter and operator regions of Matsui, K. et al.
"Tryptophan operon, peptide and protein coded thereby, tryptophan
operon utilization of tryptophan operon gene expression and
production of tryptophan," Patent: JP 1987244382-A 1 Oct. 24, 1987
E03937 Biotin-synthase Hatakeyama, K. et al. "DNA fragment
containing gene capable of coding biotin synthetase and its
utilization," Patent: JP 1992278088-A 1 Oct. 02, 1992 E04040
Diamino pelargonic acid aminotransferase Kohama, K. et al. "Gene
coding diaminopelargonic acid aminotransferase and desthiobiotin
synthetase and its utilization," Patent: JP 1992330284-A 1 Nov. 18,
1992 E04041 Desthiobiotinsynthetase Kohama, K. et al. "Gene coding
diaminopelargonic acid aminotransferase and desthiobiotin
synthetase and its utilization," Patent: JP 1992330284-A 1 Nov. 18,
1992 E04307 Flavum aspartase Kurusu, Y. et al. "Gene DNA coding
aspartase and utilization thereof," Patent: JP 1993030977-A 1 Feb.
09, 1993 E04376 Isocitric acid lyase Katsumata, R. et al. "Gene
manifestation controlling DNA," Patent: JP 1993056782-A 3 Mar. 09,
1993 E04377 Isocitric acid lyase N-terminal fragment Katsumata, R.
et al. "Gene manifestation controlling DNA," Patent: JP
1993056782-A 3 Mar. 09, 1993 E04484 Prephenate dehydratase
Sotouchi, N. et al. "Production of L-phenylalanine by
fermentation," Patent: JP 1993076352-A 2 Mar. 30, 1993 E05108
Aspartokinase Fugono, N. et al. "Gene DNA coding Aspartokinase and
its use," Patent: JP 1993184366-A 1 Jul. 27, 1993 E05112
Dihydro-dipichorinate synthetase Hatakeyama, K. et al. "Gene DNA
coding dihydrodipicolinic acid synthetase and its use," Patent: JP
1993184371-A 1 Jul. 27, 1993 E05776 Diaminopimelic acid
dehydrogenase Kobayashi, M. et al. "Gene DNA coding Diaminopimelic
acid dehydrogenase and its use," Patent: JP 1993284970-A 1 Nov. 02,
1993 E05779 Threonine synthase Kohama, K. et al. "Gene DNA coding
threonine synthase and its use," Patent: JP 1993284972-A 1 Nov. 02,
1993 E06110 Prephenate dehydratase Kikuchi, T. et al. "Production
of L-phenylalanine by fermentation method," Patent: JP 1993344881-A
1 Dec. 27, 1993 E06111 Mutated Prephenate dehydratase Kikuchi, T.
et al. "Production of L-phenylalanine by fermentation method,"
Patent: JP 1993344881-A 1 Dec. 27, 1993 E06146 Acetohydroxy acid
synthetase Inui, M. et al. "Gene capable of coding Acetohydroxy
acid synthetase and its use," Patent: JP 1993344893-A 1 Dec. 27,
1993 E06825 Aspartokinase Sugimoto, M. et al. "Mutant aspartokinase
gene," Patent: JP 1994062866-A 1 Mar. 08, 1994 E06826 Mutated
aspartokinase alpha subunit Sugimoto, M. et al. "Mutant
aspartokinase gene," Patent: JP 1994062866-A 1 Mar. 08, 1994 E06827
Mutated aspartokinase alpha subunit Sugimoto, M. et al. "Mutant
aspartokinase gene," Patent: JP 1994062866-A 1 Mar. 08, 1994 E07701
secY Honno, N. et al. "Gene DNA participating in integration of
membraneous protein to membrane," Patent: JP 1994169780-A 1 Jun.
21, 1994 E08177 Aspartokinase Sato, Y. et al, "Genetic DNA capable
of coding Aspartokinase released from feedback inhibition and its
utilization," Patent: JP 1994261766-A 1 Sep. 20, 1994 E08178,
Feedback inhibition-released Aspartokinase Sato, Y. et al. "Genetic
DNA capable of coding Aspartokinase released from E08179, feedback
inhibition and its utilization," Patent: JP 1994261766-A 1 Sep. 20,
1994 E08180, E08181, E08182 E08232, Acetohydroxy-acid
isomeroreductase Inui, M. et al. "Gene DNA coding acetohydroxy acid
isomeroreductase," Patent: JP 1994277067-A 1 Oct. 04, 1994 E08234
secE Asai, Y. et al. "Gene DNA coding for translocation machinery
of protein," Patent: JP 1994277073-A 1 Oct. 04, 1994 E08643 FT
aminotransferase and desthiobiotin Hatakeyama, K. et al. "DNA
fragment having promoter function in synthetase promoter region
coryneform bacterium," Patent: JP 1995031476-A 1 Feb. 03, 1995
E08646 Biotin synthetase Hatakeyama, K. et al. "DNA fragment having
promoter function in coryneform bacterium," Patent: JP 1995031476-A
1 Feb. 03, 1995 E08649 Aspartase Kohama, K. et al "DNA fragment
having promoter function in coryneform bacterium," Patent: JP
1995031478-A 1 Feb. 03, 1995 E08900 Dihydrodipicolinate reductase
Madori, M. et al. "DNA fragment containing gene coding
Dihydrodipicolinate acid reductase and utilization thereof,"
Patent: JP 1995075578-A 1 Mar. 20, 1995 E08901 Diaminopimelic acid
decarboxylase Madori, M. et al. "DNA fragment containing gene
coding Diaminopimelic acid decarboxylase and utilization thereof,"
Patent: JP 1995075579-A 1 Mar. 20, 1995 E12594 Serine
hydroxymethyltransferase Hatakeyama, K. et al. "Production of
L-trypophan," Patent: JP 1997028391-A
1 Feb. 04, 1997 E12760, transposase Moriya, M. et al.
"Amplification of gene using artificial transposon," Patent: JP
1997070291-A Mar. 18, 1997 E12759, E12758 E12764 Arginyl-tRNA
synthetase; diaminopimelic Moriya, M. et al. "Amplification of gene
using artificial transposon," Patent: acid decarboxylase JP
1997070291-A Mar. 18, 1997 E12767 Dihydrodipicolinic acid
synthetase Moriya, M. et al. "Amplification of gene using
artificial transposon," Patent: JP 1997070291-A Mar. 18, 1997
E12770 aspartokinase Moriya, M. et al. "Amplification of gene using
artificial transposon," Patent: JP 1997070291-A Mar. 18, 1997
E12773 Dihydrodipicolinic acid reductase Moriya, M. et al.
"Amplification of gene using artificial transposon," Patent: JP
1997070291-A Mar. 18, 1997 E13655 Glucose-6-phosphate dehydrogenase
Hatakeyama, K. et al. "Glucose-6-phosphate dehydrogenase and DNA
capable of coding the same," Patent: JP 1997224661-A 1 Sep. 02,
1997 L01508 IlvA Threonine dehydratase Moeckel, B. et al.
"Functional and structural analysis of the threonine dehydratase of
Corynebacterium glutamicum," J. Bacteriol., 174: 8065-8072 (1992)
L07603 EC 4.2.1.15 3-deoxy-D-arabinoheptulosonate-7- Chen, C. et
al. "The cloning and nucleotide sequence of Corynebacterium
phosphate synthase glutamicum
3-deoxy-D-arabinoheptulosonate-7-phosphate synthase gene," FEMS
Microbiol. Lett., 107: 223-230 (1993) L09232 IlvB; ilvN; ilvC
Acetohydroxy acid synthase large subunit; Keilhauer, C. et al.
"Isoleucine synthesis in Corynebacterium glutamicum: Acetohydroxy
acid synthase small subunit; molecular analysis of the
ilvB-ilvN-ilvC operon," J. Bacteriol., 175(17): 5595-5603
Acetohydroxy acid isomeroreductase (1993) L18874 PtsM
Phosphoenolpyruvate sugar Fouet, A et al. "Bacillus subtilis
sucrose-specific enzyme II of the phosphotransferase
phosphotransferase system: expression in Escherichia coli and
homology to enzymes II from enteric bacteria," PNAS USA, 84(24):
8773-8777 (1987); Lee, J. K. et al. "Nucleotide sequence of the
gene encoding the Corynebacterium glutamicum mannose enzyme II and
analyses of the deduced protein sequence," FEMS Microbiol. Lett.,
119(1-2): 137-145 (1994) L27123 aceB Malate synthase Lee, H-S. et
al. "Molecular characterization of aceB, a gene encoding malate
synthase in Corynebacterium glutamicum," J. Microbiol. Biotechnol.,
4(4): 256-263 (1994) L27126 Pyruvate kinase Jetten, M. S. et al.
"Structural and functional analysis of pyruvate kinase from
Corynebacterium glutamicum," Appl. Environ. Microbiol., 60(7):
2501-2507 (1994) L28760 aceA Isocitrate lyase L35906 dtxr
Diphtheria toxin repressor Oguiza, J. A. et al. "Molecular cloning,
DNA sequence analysis, and characterization of the Corynebacterium
diphtheriae dtxR from Brevibacterium lactofermentum," J.
Bacteriol., 177(2): 465-467 (1995) M13774 Prephenate dehydratase
Follettie, M. T. et al. "Molecular cloning and nucleotide sequence
of the Corynebacterium glutamicum pheA gene," J. Bacteriol., 167:
695-702 (1986) M16175 5S rRNA Park, Y-H. et al. "Phylogenetic
analysis of the coryneform bacteria by 56 rRNA sequences," J.
Bacteriol., 169: 1801-1806 (1987) M16663 trpE Anthranilate
synthase, 5' end Sano, K. et al. "Structure and function of the trp
operon control regions of Brevibacterium lactofermentum, a
glutamic-acid-producing bacterium," Gene, 52: 191-200 (1987) M16664
trpA Tryptophan synthase, 3'end Sano, K. et al. "Structure and
function of the trp operon control regions of Brevibacterium
lactofermentum, a glutamic-acid-producing bacterium," Gene, 52:
191-200 (1987) M25819 Phosphoenolpyruvate carboxylase O'Regan, M.
et al. "Cloning and nucleotide sequence of the Phosphoenolpyruvate
carboxylase-coding gene of Corynebacterium glutamicum ATCC13032,"
Gene, 77(2): 237-251 (1989) M85106 23S rRNA gene insertion sequence
Roller, C. et al. "Gram-positive bacteria with a high DNA G + C
content are characterized by a common insertion within their 23S
rRNA genes," J. Gen. Microbiol., 138: 1167-1175 (1992) M85107, 23S
rRNA gene insertion sequence Roller, C. et al. "Gram-positive
bacteria with a high DNA G + C content are M85108 characterized by
a common insertion within their 23S rRNA genes," J. Gen.
Microbiol., 138: 1167-1175 (1992) M89931 aecD; brnQ; yhbw Beta C-S
lyase; branched-chain amino acid Rossol, I. et al. "The
Corynebacterium glutamicum aecD gene encodes a C-S uptake carrier;
hypothetical protein yhbw lyase with alpha, beta-elimination
activity that degrades aminoethylcysteine," J. Bacteriol., 174(9):
2968-2977 (1992); Tauch, A. et al. "Isoleucine uptake in
Corynebacterium glutamicum ATCC 13032 is directed by the brnQ gene
product," Arch. Microbiol., 169(4): 303-312 (1998) S59299 trp
Leader gene (promoter) Herry, D. M. et al. "Cloning of the trp gene
cluster from a tryptophan- hyperproducing strain of Corynebacterium
glutamicum: identification of a mutation in the trp leader
sequence," Appl. Environ. Microbiol., 59(3): 791-799 (1993) U11545
trpD Anthranilate phosphoribosyltransferase O'Gara, J. P. and
Dunican, L. K. (1994) Complete nucleotide sequence of the
Corynebacterium glutamicum ATCC 21850 tpD gene." Thesis,
Microbiology Department, University College Galway, Ireland. U13922
cglIM; cglIR; clgIIR Putative type II 5-cytosoine Schafer, A. et
al. "Cloning and characterization of a DNA region encoding a
methyltransferase; putative type II stress-sensitive restriction
system from Corynebacterium glutamicum ATCC restriction
endonuclease; putative type I or 13032 and analysis of its role in
intergeneric conjugation with Escherichia type III restriction
endonuclease coli," J. Bacteriol., 176(23): 7309-7319 (1994);
Schafer, A. et al. "The Corynebacterium glutamicum cglIM gene
encoding a 5-cytosine in an McrBC- deficient Escherichia coli
strain," Gene, 203(2): 95-101 (1997) U14965 recA U31224 ppx Ankri,
S. et al. "Mutations in the Corynebacterium glutamicumproline
biosynthetic pathway: A natural bypass of the proA step," J.
Bacteriol., 178(15): 4412-4419 (1996) U31225 proC L-proline: NADP+
5-oxidoreductase Ankri, S. et al. "Mutations in the Corynebacterium
glutamicumproline biosynthetic pathway: A natural bypass of the
proA step," J. Bacteriol., 178(15): 4412-4419 (1996) U31230 obg;
proB; unkdh ?; gamma glutamyl kinase; similar to D- Ankri, S. et
al. "Mutations in the Corynebacterium glutamicumproline isomer
specific 2-hydroxyacid biosynthetic pathway: A natural bypass of
the proA step," J. Bacteriol., dehydrogenases 178(15): 4412-4419
(1996) U31281 bioB Biotin synthase Serebriiskii, I. G., "Two new
members of the bio B superfamily: Cloning, sequencing and
expression of bio B genes of Methylobacillus flagellatum and
Corynebacterium glutamicum," Gene, 175: 15-22 (1996) U35023 thtR;
accBC Thiosulfate sulfurtransferase; acyl CoA Jager, W. et al. "A
Corynebacterium glutamicum gene encoding a two-domain carboxylase
protein similar to biotin carboxylases and biotin-carboxyl-carrier
proteins," Arch. Microbiol., 166(2); 76-82 (1996) U43535 cmr
Multidrug resistance protein Jager, W. et al. "A Corynebacterium
glutamicum gene conferring multidrug resistance in the heterologous
host Escherichia coli," J. Bacteriol., 179(7): 2449-2451 (1997)
U43536 clpB Heat shock ATP-binding protein U53587 aphA-3
3'5''-aminoglycoside phosphotransferase U89648 Corynebacterium
glutamicum unidentified sequence involved in histidine
biosynthesis, partial sequence X04960 trpA; trpB; trpC; trpD;
Tryptophan operon Matsui, K. et al. "Complete nucleotide and
deduced amino acid sequences of trpE; trpG; trpL the Brevibacterium
lactofermentum tryptophan operon," Nucleic Acids Res., 14(24):
10113-10114 (1986) X07563 lys A DAP decarboxylase
(meso-diaminopimelate Yeh, P. et al. "Nucleic sequence of the lysA
gene of Corynebacterium decarboxylase, EC 4.1.1.20) glutamicum and
possible mechanisms for modulation of its expression," Mol. Gen.
Genet., 212(1): 112-119 (1988) X14234 EC 4.1.1.31
Phosphoenolpyruvate carboxylase Eikmanns, B. J. et al. "The
Phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum:
Molecular cloning, nucleotide sequence, and expression," Mol. Gen.
Genet., 218(2): 330-339 (1989); Lepiniec, L. et al. "Sorghum
Phosphoenolpyruvate carboxylase gene family: structure, function
and molecular evolution," Plant. Mol. Biol., 21 (3): 487-502 (1993)
X17313 fda Fructose-bisphosphate aldolase Von der Osten, C. H. et
al. "Molecular cloning, nucleotide sequence and fine- structural
analysis of the Corynebacterium glutamicum fda gene: structural
comparison of C. glutamicum fructose-1,6-biphosphate aldolase to
class I and class II aldolases," Mol. Microbiol., X53993 dapA
L-2,3-dihydrodipicolinate synthetase (EC Bonnassie, S. et al.
"Nucleic sequence of the dapA gene from 4.2.1.52) Corynebacterium
glutamicum," Nucleic Acids Res., 18(21): 6421 (1990) X54223
AttB-related site Cianciotto, N. et al. "DNA sequence homology
between att B-related sites of Corynebacterium diphtheriae,
Corynebacterium ulcerans, Corynebacterium glutamicum, and the attP
site of lambdacorynephage," FEMS. Microbiol, Lett., 66: 299-302
(1990) X54740 argS; lysA Arginyl-tRNA synthetase; Diaminopimelate
Marcel, T. et al. "Nucleotide sequence and organization of the
upstream region decarboxylase of the Corynebacterium glutamicum
lysA gene," Mol. Microbiol., 4(11): 1819-1830 (1990) X55994 trpL;
trpE Putative leader peptide; anthranilate Heery, D. M. et al.
"Nucleotide sequence of the Corynebacterium glutamicum synthase
component 1 trpE gene," Nucleic Acids Res., 18(23): 7138 (1990)
X56037 thrC Threonine synthase Han, K. S. et al. "The molecular
structure of the Corynebacterium glutamicum threonine synthase
gene," Mol. Microbiol., 4(10): 1693-1702 (1990) X56075 attB-related
site Attachment site Cianciotto, N. et al. "DNA sequence homology
between att B-related sites of Corynebacterium diphtheriae,
Corynebacterium ulcerans, Corynebacterium glutamicum, and the attP
site of lambdacorynephage," FEMS. Microbiol, Lett., 66: 299-302
(1990) X57226 lysC-alpha; lysC-beta; Aspartokinase-alpha subunit;
Kalinowski, J. et al. "Genetic and biochemical analysis of the
Aspartokinase asd Aspartokinase-beta subunit; aspartate beta from
Corynebacterium glutamicum," Mol. Microbiol., 5(5): 1197-1204
(1991); semialdehyde dehydrogenase Kalinowski, J. et al.
"Aspartokinase genes lysC alpha and lysC beta overlap and are
adjacent to the aspertate beta-semialdehyde dehydrogenase gene asd
in Corynebacterium glutamicum," Mol. Gen. Genet., 224(3): 317-324
(1990) X59403 gap; pgk; tpi Glyceraldehyde-3-phosphate; Eikmanns,
B. J. "Identification, sequence analysis, and expression of a
phosphoglycerate kinase; triosephosphate Corynebacterium glutamicum
gene cluster encoding the three glycolytic isomerase enzymes
glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate
kinase, and triosephosphate isomeras," J. Bacteriol., 174(19):
6076-6086 (1992) X59404 gdh Glutamate dehydrogenase Bormann, E. R.
et al. "Molecular analysis of the Corynebacterium glutamicum gdh
gene encoding glutamate dehydrogenase," Mol. Microbiol., 6(3):
317-326 (1992) X60312 lysI L-lysine permease Seep-Feldhaus, A. H.
et al. "Molecular analysis of the Corynebacterium glutamicum lysl
gene involved in lysine uptake," Mol. Microbiol., 5(12): 2995-3005
(1991) X66078 cop1 Ps1 protein Joliff, G. et al. "Cloning and
nucleotide sequence of the csp1 gene encoding PS1, one of the two
major secreted proteins of Corynebacterium glutamicum: The deduced
N-terminal region of PS1 is similar to the Mycobacterium antigen 85
complex," Mol. Microbiol., 6(16): 2349-2362 (1992) X66112 glt
Citrate synthase Eikmanns, B. J. et al. "Cloning sequence,
expression and transcriptional analysis of the Corynebacterium
glutamicum gltA gene encoding citrate synthase," Microbiol., 140:
1817-1828 (1994) X67737 dapB Dihydrodipicolinate reductase X69103
csp2 Surface layer protein PS2 Peyret, J. L. et al.
"Characterization of the cspB gene encoding PS2, an ordered
surface-layer protein in Corynebacterium glutamicum," Mol.
Microbiol.,
91: 97-109 (1993) X69104 IS3 related insertion element Bonamy, C.
et al. "Identification of IS1206, a Corynebacterium glutamicum
IS3-related insertion sequence and phylogenetic analysis," Mol.
Microbiol., 14(3): 571-581 (1994) X70959 leuA Isopropylmalate
synthase Patek, M. et al. "Leucine synthesis in Corynebacterium
glutamicum: enzyme activities, structure of leuA, and effect of
leuA inactivation on lysine synthesis," Appl. Environ. Microbiol.,
60(1): 133-140 (1994) X71489 icd Isocitrate dehydrogenase (NADP+)
Eikmanns, B. J. et al. "Cloning sequence analysis, expression, and
inactivation of the Corynebacterium glutamicum icd gene encoding
isocitrate dehydrogenase and biochemical characterization of the
enzyme," J. Bacteriol., 177(3): 774-782 (1995) X72855 GDHA
Glutamate dehydrogenase (NADP+) X75083, mtrA 5-methyltryptophan
resistance Heery, D. M. et al. "A sequence from a
tryptophan-hyperproducing strain of X70584 Corynebacterium
glutamicum encoding resistance to 5-methyltryptophan," Biochem.
Biophys. Res. Commun., 201(3): 1255-1262 (1994) X75085 recA
Fitzpatrick, R. et al. "Construction and characterization of recA
mutant strains of Corynebacterium glutamicum and Brevibacterium
lactofermentum," Appl. Microbiol. Biotechnol., 42(4): 575-580
(1994) X75504 aceA; thiX Partial Isocitrate lyase; ? Reinscheid, D.
J. et al. "Characterization of the isocitrate lyase gene from
Corynebacterium glutamicum and biochemical analysis of the enzyme,"
J. Bacteriol., 176(12): 3474-3483 (1994) X76875 ATPase beta-subunit
Ludwig, W. et al. "Phylogenetic relationships of bacteria based on
comparative sequence analysis of elongation factor Tu and
ATP-synthase beta-subunit genes," Antonie Van Leeuwenhoek, 64:
285-305 (1993) X77034 tuf Elongation factor Tu Ludwig, W. et al.
"Phylogenetic relationships of bacteria based on comparative
sequence analysis of elongation factor Tu and ATP-synthase
beta-subunit genes," Antonie Van Leeuwenhoek, 64: 285-305 (1993)
X77384 recA Billman-Jacobe, H. "Nucleotide sequence of a recA gene
from Corynebacterium glutamicum," DNA Seq., 4(6): 403-404 (1994)
X78491 aceB Malate synthase Reinscheid, D. J. et al. "Malate
synthase from Corynebacterium glutamicum pta-ack operon encoding
phosphotransacetylase: sequence analysis," Microbiology. 140:
3099-3108 (1994) X80629 16S rDNA 16S ribosomal RNA Rainey, F. A. et
al. "Phylogenetic analysis of the genera Rhodococcus and Norcardia
and evidence for the evolutionary origin of the genus Norcardia
from within the radiation of Rhodococcus species," Microbiol., 141:
523-528 (1995) X81191 gluA; gluB; gluC; Glutamate uptake system
Kronemeyer, W. et al. "Structure of the gluABCD cluster encoding
the gluD glutamate uptake system of Corynebacterium glutamicum," J.
Bacteriol., 177(5): 1152-1158 (1995) X81379 dapE
Succinyldiaminopimelate desuccinylase Wehrmann, A. et al. "Analysis
of different DNA fragments of Corynebacterium glutamicum
complementing dapE of Escherichia coli," Microbiology, 40: 3349-56
(1994) X82061 16S rDNA 16S ribosomal RNA Ruimy, R. et al.
"Phylogeny of the genus Corynebacterium deduced from analyses of
small-subunit ribosomal DNA sequences," Int. J. Syst. Bacteriol.,
45(4): 740-746 (1995) X82928 asd; lysC Aspartate-semialdehyde
dehydrogenase; ? Serebrijski, I. et al. "Multicopy suppression by
asd gene and osmotic stress- dependent complementation by
heterologous proA in proA mutants," J. Bacteriol., 177(24):
7255-7260 (1995) X82929 proA Gamma-glutamyl phosphate reductase
Serebrijski, I. et al. "Multicopy suppression by asd gene and
osmotic stress- dependent complementation by heterologous proA in
proA mutants," J. Bacteriol., 177(24): 7255-7260 (1995) X84257 16S
rDNA 16S ribosomal RNA Pascual, C. et al. "Phylogenetic analysis of
the genus Corynebacterium based on 16S rRNA gene sequences," Int.
J. Syst. Bacteriol., 45(4): 724-728 (1995) X85965 aroP; dapE
Aromatic amino acid permease; ? Wehrmann, A. et al. "Functional
analysis of sequences adjacent to dapE of Corynebacterium
glutamicumproline reveals the presence of aroP, which encodes the
aromatic amino acid transporter," J. Bacteriol., 177(20): 5991-5993
(1995) X86157 argB; argC; argD; Acetylglutamate kinase;
N-acetyl-gamma- Sakanyan, V. et al. "Genes and enzymes of the
acetyl cycle of arginine argF; argJ glutamyl-phosphate reductase;
biosynthesis in Corynebacterium glutamicum: enzyme evolution in the
early acetylornithine aminotransferase; ornithine steps of the
arginine pathway," Microbiology, 142: 99-108 (1996)
carbamoyltransferase; glutamate N- acetyltransferase X89084 pta;
ackA Phosphate acetyltransferase; acetate kinase Reinscheid, D. J.
et al. "Cloning, sequence analysis, expression and inactivation of
the Corynebacterium glutamicum pta-ack operon encoding
phosphotransacetylase and acetate kinase," Microbiology, 145:
503-513 (1999) X89850 attB Attachment site Le Marrec, C. et al.
"Genetic characterization of site-specific integration functions of
phi AAU2 infecting "Arthrobacter aureus C70," J. Bacteriol.,
178(7): 1996-2004 (1996) X90356 Promoter fragment F1 Patek, M. et
al. "Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90357 Promoter fragment F2 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90358 Promoter fragment F10 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90359 Promoter fragment F13 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90360 Promoter fragment F22 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90361 Promoter fragment F34 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90362 Promoter fragment F37 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90363 Promoter fragment F45 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90364 Promoter fragment F64 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90365 Promoter fragment F75 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90366 Promoter fragment PF101 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90367 Promoter fragment PF104 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X90368 Promoter fragment PF109 Patek, M. et al.
"Promoters from Corynebacterium glutamicum: cloning, molecular
analysis and search for a consensus motif," Microbiology, 142:
1297-1309 (1996) X93513 amt Ammonium transport system Siewe, R. M.
et al. "Functional and genetic characterization of the (methyl)
ammonium uptake carrier of Corynebacterium glutamicum," J. Biol.
Chem., 271(10): 5398-5403 (1996) X93514 betP Glycine betaine
transport system Peter, H. et al. "Isolation, characterization, and
expression of the Corynebacterium glutamicum betP gene, encoding
the transport system for the compatible solute glycine betaine," J.
Bacteriol., 178(17): 5229-5234 (1996) X95649 orf4 Patek, M. et al.
"Identification and transcriptional analysis of the dapB-ORF2-
dapA-ORF4 operon of Corynebacterium glutamicum, encoding two
enzymes involved in L-lysine synthesis," Biotechnol. Lett., 19:
1113-1117 (1997) X96471 lysE; lysG Lysine exporter protein; Lysine
export Vrljic, M. et al. "A new type of transporter with a new type
of cellular regulator protein function: L-lysine export from
Corynebacterium glutamicum," Mol. Microbiol., 22(5): 815-826 (1996)
X96580 panB; panC; xylB 3-methyl-2-oxobutanoate Sahm, H. et al.
"D-pantothenate synthesis in Corynebacterium glutamicum and
hydroxymethyltransferase; pantoate-beta- use of panBC and genes
encoding L-valine synthesis for D-pantothenate alanine ligase;
xylulokinase overproduction," Appl. Environ. Microbiol., 65(5):
1973-1979 (1999) X96962 Insertion sequence IS1207 and transposase
X99289 Elongation factor P Ramos, A. et al. "Cloning, sequencing
and expression of the gene encoding elongation factor P in the
amino-acid producer Brevibacterium lactofermentum (Corynebacterium
glutamicum ATCC 13869)," Gene, 198: 217-222 (1997) Y00140 thrB
Homoserine kinase Mateos, L. M. et al. "Nucleotide sequence of the
homoserine kinase (thrB) gene of the Brevibacterium
lactofermentum," Nucleic Acids Res., 15(9): 3922 (1987) Y00151 ddh
Meso-diaminopimelate D-dehydrogenase Ishino, S. et al. "Nucleotide
sequence of the meso-diammopimelate D- (EC 1.4.1.16) dehydrogenase
gene from Corynebacterium glutamicum," Nucleic Acids Res., 15(9):
3917 (1987) Y00476 thrA Homoserine dehydrogenase Mateos, L. M. et
al. "Nucleotide sequence of the homoserine dehydrogenase (thrA)
gene of the Brevibacterium lactofermentum," Nucleic Acids Res.,
15(24): 10598 (1987) Y00546 hom; thrB Homoserine dehydrogenase;
homoserine Peoples, O. P. et al. "Nucleotide sequence and fine
structural analysis of the kinase Corynebacterium glutamicum
hom-thrB operon," Mol. Microbiol., 2(1): 63-72 (1988) Y08964 murC;
ftsQ/divD; ftsZ UPD-N-acetylmuramate-alanine ligase; Honrubia, M.
P. et al. "Identification, characterization, and chromosomal
division initiation protein or cell division organization of the
ftsZ gene from Brevibacterium lactofermentum," Mol. Gen. protein;
cell division protein Genet., 259(1): 97-104 (1998) Y09163 putP
High affinity proline transport system Peter, H. et al. "Isolation
of the putP gene of Corynebacterium glutamicumproline and
characterization of a low-affinity uptake system for compatible
solutes," Arch. Microbiol., 168(2): 143-151 (1997) Y09548 pyc
Pyruvate carboxylase Peters-Wendisch, P. G. et al. "Pyruvate
carboxylase from Corynebacterium glutamicum: characterization,
expression and inactivation of the pyc gene," Microbiology, 144:
915-927 (1998) Y09578 leuB 3-isopropylmalate dehydrogenase Patek,
M. et al. "Analysis of the leuB gene from Corynebacterium
glutamicum," Appl. Microbiol. Biotechnol., 50(1): 42-47 (1998)
Y12472 Attachment site bacteriophage Phi-16 Moreau, S. et al.
"Site-specific integration of corynephage Phi-16: The construction
of an integration vector," Microbiol., 145: 539-548 (1999) Y12537
proP Proline/ectoine uptake system protein Peter, H. et al.
"Corynebacterium glutamicum is equipped with four secondary
carriers for compatible solutes: Identification, sequencing, and
characterization of the proline/ectoine uptake system, ProP, and
the ectoine/proline/glycine betaine carrier, EctP," J. Bacteriol.,
180(22): 6005-6012 (1998) Y13221 glnA Glutamine synthetase I
Jakoby, M. et al. "Isolation of Corynebacterium glutamicum glnA
gene encoding glutamine synthetase I," FEMS Microbiol. Lett.,
154(1): 81-88 (1997) Y16642 lpd Dihydrolipoamide dehydrogenase
Y18059 Attachment site Corynephage 304L Moreau, S. et al. "Analysis
of the integration functions of φ 304L: An integrase module among
corynephages," Virology, 255(1): 150-159 (1999) Z21501 argS; lysA
Arginyl-tRNA synthetase; diaminopimelate Oguiza, J. A. et al. "A
gene encoding arginyl-tRNA synthetase is located in the
decarboxylase (partial) upstream region of the lysA gene in
Brevibacterium lactofermentum: Regulation of argS-lysA cluster
expression by arginine," J. Bacteriol., 175(22): 7356-7362 (1993)
Z21502 dapA; dapB Dihydrodipicolinate synthase; Pisabarro, A. et
al. "A
cluster of three genes (dapA, orf2, and dapB) of
dihydrodipicolinate reductase Brevibacterium lactofermentum encodes
dihydrodipicolinate reductase, and a third polypeptide of unknown
function," J. Bacteriol., 175(9): 2743-2749 1993 Z29563 thrC
Threonine synthase Malumbres, M. et al. "Analysis and expression of
the thrC gene of the encoded threonine synthase," Appl. Environ.
Microbiol., 60(7)2209-2219 (1994) Z46753 16S rDNA Gene for 16S
ribosomal RNA Z49822 sigA SigA sigma factor Oguiza, J. A. et al
"Multiple sigma factor genes in Brevibacterium lactofermentum:
Characterization of sigA and sigB," J. Bacteriol., 178(2): 550-553
(1996) Z49823 galE; dtxR Catalytic activity UDP-galactose 4-
Oguiza, J. A. et al "The galE gene encoding the UDP-galactose
4-epimerase of epimerase; diphtheria toxin regulatory
Brevibacterium lactofermentum is coupled transcriptionally to the
dmdR protein gene," Gene, 177: 103-107 (1996) Z49824 orfl; sigB ?;
SigB sigma factor Oguiza, J. A. et al "Multiple sigma factor genes
in Brevibacterium lactofermentum: Characterization of sigA and
sigB," J. Bacteriol., 178(2): 550-553 (1996) Z66534 Transposase
Correia, A. et al. "Cloning and characterization of an IS-like
element present in the genome of Brevibacterium lactofermentum ATCC
13869," Gene, 170(1): 91-94 (1996) .sup.1A sequence for this gene
was published in the indicated reference. However, the sequence
obtained by the inventors of the present application is
significantly longer than the published version. It is believed
that the published version relied on an incorrect start codon, and
thus represents only a fragment of the actual coding region.
[0171] TABLE-US-00004 TABLE 1 GENES IN THE APPLICATION Nucleic
Amino Acid Acid SEQ SEQ Identification ID NO ID NO Code Contig. NT
Start NT Stop 1 2 RXN01638 VV0005 54646 55545 3 4 F RXA01638
GR00456 825 436 5 6 F RXA01639 GR00456 1334 897 7 8 RXN01590 VV0015
66740 60294 9 10 F RXA01590 GR00445 1710 427 11 12 F RXA01542
GR00429 3 5063 13 14 RXN01539 VV0015 60006 57841 15 16 F RXA01539
GR00428 120 2042 17 18 RXN01422 VV0122 17001 16030 19 20 F RXA01422
GR00416 2003 1221 21 22 RXN01403 VV0126 4644 3997 23 24 F RXA01403
GR00409 4410 3997 25 26 RXN01326 VV0102 23923 24288 27 28 F
RXA01326 GR00386 45 338 29 30 RXN01301 VV0068 8224 8748 31 32 F
RXA01301 GR00375 1993 1589 33 34 RXN01276 VV0009 31190 31633 35 36
F RXA01276 GR00367 29993 30538 37 38 RXN01231 VV0020 30144 29902 39
40 F RXA01231 GR00356 1384 1887 41 42 RXN01210 VV0169 4230 5060 43
44 F RXA01210 GR00349 3 695 45 46 RXN01206 VV0268 303 4 47 48 F
RXA01206 GR00346 593 853 49 50 RXN01121 VV0182 5808 6893 51 52 F
RXA01121 GR00310 2479 3156 53 54 RXN01085 VV0093 16599 15721 55 56
F RXA01085 GR00303 960 4 57 58 RXN00022 VV0015 27262 28962 59 60 F
RXA00022 GR00002 20563 21297 61 62 F RXA01921 GR00551 943 5 63 64
RXN00027 VV0127 60015 59650 65 66 F RXA00027 GR00003 5142 5507 67
68 RXN00028 VV0127 57099 59045 69 70 F RXA00028 GR00003 8058 6112
71 72 RXN00033 VV0127 51753 53087 73 74 RXN00056 VV0044 11980 12729
75 76 F RXA00056 GR00009 1463 714 77 78 RXN00067 VV0019 29740 29255
79 80 F RXA00067 GR00011 708 223 81 82 RXN00077 VV0154 4222 5583 83
84 F RXA00077 GR00012 4228 5589 85 86 RXN00080 VV0154 8446 6917 87
88 F RXA00080 GR00012 7342 6923 89 90 RXN00087 VV0048 204 731 91 92
F RXA00087 GR00013 3983 3456 93 94 RXN00096 VV0129 22302 22000 95
96 F RXA00096 GR00014 4746 5048 97 98 RXN00097 VV0129 21841 20666
99 100 F RXA00097 GR00014 5222 6382 101 102 RXN00114 VV0129 5849
6337 103 104 F RXA00114 GR00017 3420 3908 105 106 RXN00120 VV0142
2612 3451 107 108 F RXA00120 GR00019 2798 3451 109 110 RXN00128
VV0124 7960 9663 111 112 F RXA00128 GR00020 4709 3006 113 114
RXN00154 VV0167 3283 4125 115 116 F RXA00154 GR00023 8568 7726 117
118 RXN00162 VV0084 9489 9842 119 120 F RXA00162 GR00024 5438 5791
121 122 RXN00167 VV0232 4324 4821 123 124 F RXA00167 GR00025 4324
4584 125 126 RXN00171 VV0031 5311 5054 127 128 F RXA00171 GR00026
10316 10086 129 130 RXN00194 VV0115 4174 4614 131 132 F RXA00194
GR00030 290 6 133 134 RXN00197 VV0115 2733 1522 135 136 F RXA00197
GR00030 1731 2741 137 138 RXN00216 VV0096 16292 15303 139 140
RXN00222 VV0096 21079 22224 141 142 F RXA00222 GR00032 21073 22218
143 144 RXN00232 VV0214 601 92 145 146 F RXA00232 GR00035 527 18
147 148 RXN00236 VV0133 3300 2575 149 150 F RXA00236 GR00036 3300
2575 151 152 RXN00242 VV0133 7031 8308 153 154 F RXA00242 GR00036
7031 8233 155 156 RXN00247 VV0057 35082 34156 157 158 F RXA00247
GR00037 7097 6171 159 160 RXN00256 VV0015 3794 4564 161 162 F
RXA00256 GR00039 968 1738 163 164 RXN00264 VV0123 14046 13669 165
166 F RXA00264 GR00040 2459 2836 167 168 RXN00267 VV0123 12366
12683 169 170 F RXA00267 GR00040 4091 3822 171 172 RXN00271 VV0019
4975 3986 173 174 F RXA00271 GR00041 3709 2720 175 176 RXN00272
VV0019 5686 6057 177 178 F RXA00272 GR00041 4420 4791 179 180
RXN00283 VV0127 33097 32066 181 182 F RXA00283 GR00045 142 1269 183
184 RXN00334 VV0197 3581 3246 185 186 F RXA00334 GR00057 16762
17097 187 188 RXN00338 VV0197 26797 25658 189 190 F RXA00338
GR00059 1 783 191 192 F RXA00318 GR00055 426 635 193 194 RXN00342
VV0049 1576 1148 195 196 F RXA00342 GR00061 73 501 197 198 RXN00344
VV0135 42719 43597 199 200 F RXA00344 GR00063 6 584 201 202
RXN00353 VV0135 32107 32799 203 204 F RXA00353 GR00068 988 1680 205
206 RXN00354 VV0135 33604 32792 207 208 RXN00362 VV0176 33334 34680
209 210 F RXA00362 GR00073 2 961 211 212 RXN00373 VV0226 6002 6340
213 214 F RXA00373 GR00079 342 4 215 216 RXN00390 VV0025 9834 9430
217 218 F RXA00390 GR00086 1437 1841 219 220 RXN00399 VV0025 13735
13421 221 222 F RXA00399 GR00087 830 1144 223 224 RXN00416 VV0181 1
225 226 F RXA00416 GR00093 1 327 227 228 F RXA00418 GR00094 1 1065
229 230 RXN00422 VV0112 3820 4713 231 232 F RXA00422 GR00097 428 6
233 234 RXN00447 VV0112 23325 22906 235 236 F RXA00447 GR00108 518
817 237 238 RXN00455 VV0076 5523 4774 239 240 F RXA00455 GR00113 2
619 241 242 RXN00473 VV0086 31493 32281 243 244 F RXA00473 GR00119
5799 6563 245 246 RXN00485 VV0086 51200 48906 247 248 F RXA00485
GR00119 25230 23188 249 250 RXN00496 VV0086 17452 18477 251 252 F
RXA00496 GR00123 1776 2177 253 254 RXN00503 VV0086 11688 13409 255
256 RXN00504 VV0086 13486 13905 257 258 F RXA00504 GR00125 5007
5252 259 260 RXN00505 VV0086 5810 6304 261 262 F RXA00505 GR00126 1
252 263 264 RXN00507 VV0086 4606 3752 265 266 F RXA00507 GR00127
1098 244 267 268 RXN00510 VV0086 1924 3432 269 270 F RXA00509
GR00128 316 140 271 272 F RXA00510 GR00128 384 914 273 274 RXN00515
VV0144 3289 2588 275 276 F RXA00515 GR00131 3 482 277 278 F
RXA00520 GR00132 599 796 279 280 RXN00527 VV0079 23845 25608 281
282 F RXA00527 GR00136 3123 1360 283 284 RXN00547 VV0079 33886
35283 285 286 F RXA00547 GR00142 641 1054 287 288 F RXA00546
GR00142 1 690 289 290 RXN00552 VV0079 27617 28552 291 292 F
RXA00552 GR00145 2 718 293 294 RXN00555 VV0079 30437 29499 295 296
F RXA00555 GR00145 2555 1665 297 298 RXN00560 VV0103 7606 7980 299
300 F RXA00560 GR00149 256 492 301 302 RXN00574 VV0323 16133 15255
303 304 F RXA00574 GR00156 767 1645 305 306 RXN00589 VV0323 2680
2231 307 308 F RXA00589 GR00156 14220 14582 309 310 RXN00616 VV0054
5670 5326 311 312 F RXA00616 GR00162 3574 3918 313 314 RXN00647
VV0109 12861 12229 315 316 F RXA00647 GR00169 641 1273 317 318
RXN00653 VV0109 6578 7342 319 320 F RXA00653 GR00169 6924 6160 321
322 RXN00662 VV0142 7711 8979 323 324 F RXA00662 GR00172 2671 1403
325 326 RXN00666 VV0109 1566 2480 327 328 F RXA00666 GR00175 390 4
329 330 RXN00704 VV0005 9240 9866 331 332 F RXA00704 GR00183 2972
3484 333 334 RXN00712 VV0005 1195 500 335 336 F RXA00712 GR00187
1048 500 337 338 RXN00720 VV0232 4899 5564 339 340 F RXA00720
GR00188 7665 7000 341 342 RXN00722 VV0052 2 343 344 F RXA00722
GR00189 1015 512 345 346 RXN00729 VV0024 3903 2926 347 348 F
RXA00729 GR00194 1 642 349 350 F RXA02867 GR10008 610 5 351 352
RXN00730 VV0024 2031 2837 353 354 F RXA00730 GR00194 1063 731 355
356 RXN00731 VV0133 8314 10809 357 358 F RXA00731 GR00195 2613 142
359 360 RXN00738 VV0254 3 361 362 F RXA00738 GR00201 78 365 363 364
RXN00750 VV0010 30086 30523 365 366 F RXA00750 GR00202 18937 19374
367 368 RXN00762 VV0103 16953 17828 369 370 RXN00768 VV0103 12997
11879 371 372 F RXA00768 GR00204 5956 6399 373 374 F RXA00767
GR00204 5280 5993 375 376 RXN00769 VV0103 11654 11442 377 378 F
RXA00769 GR00204 6624 6836 379 380 RXN00771 VV0103 26639 27457 381
382 F RXA00771 GR00205 857 180 383 384 RXN00785 VV0321 2 658 385
386 F RXA00785 GR00207 625 5 387 388 RXN00795 VV0321 6259 5732 389
390 F RXA00795 GR00211 4228 4755 391 392 RXN00831 VV0180 4205 4906
393 394 F RXA00831 GR00224 1662 961 395 396 RXN00835 VV0138 12068
13021 397 398 F RXA00835 GR00226 3 692 399 400 RXN00836 VV0138
13126 14841 401 402 F RXA00836 GR00226 797 2467 403 404 RXN00840
VV0138 6220 6933 405 406 F RXA00840 GR00228 742 1455 407 408
RXN00841 VV0138 6944 7480 409 410 F RXA00841 GR00228 1466 2002 411
412 RXN00846 VV0138 2367 1498 413 414 F RXA00846 GR00230 391 5 415
416 RXN00850 VV0067 4148 3321 417 418 RXN00854 VV0067 371 159 419
420 F RXA00854 GR00231 4708 4920 421 422 RXN00855 VV0255 735 1019
423 424 F RXA00855 GR00232 526 242 425 426 RXN00869 VV0127 5599
4679 427 428 F RXA00869 GR00239 1 792 429 430 RXN00915 VV0238 886
257 431 432 F RXA00915 GR00251 514 5 433 434 RXN00917 VV0238 7202
4524 435 436 F RXA00917 GR00251 5534 4152 437 438 RXN00921 VV0373 1
513 439 440 F RXA00921 GR00252 4750 2852 441 442 RXN00943 VV0116
11376 12287 443 444 F RXA00943 GR00258 3 509 445 446 F RXA02423
GR00706 221 6 447 448 RXN00945 VV0107 1876 2847 449 450 RXN00946
VV0107 3034 3807 451 452 F RXA00946 GR00259 3034 3807 453 454
RXN00953 VV0260 1834 1082 455 456 RXN00959 VV0208 402 857 457 458 F
RXA00959 GR00265 402 728 459 460 RXN00963 VV0249 1816 2652 461 462
F RXA00963 GR00269 442 5 463 464 RXN00971 VV0149 14706 14389 465
466 F RXA00971 GR00273 1421 1149 467 468 RXN00991 VV0210 4424 3045
469 470 RXN01004 VV0210 3045 1984 471 472 RXN01016 VV0209 14476
15123 473 474 F RXA01016 GR00290 1141 494 475 476 RXN01023 VV0143
2343 3320 477 478 F RXA01023 GR00292 1817 867 479 480 RXN01028
VV0015 29000 31048 481 482 F RXA01028 GR00295 3 626
483 484 F RXA01812 GR00514 3 1232 485 486 RXN01069 VV0030 986 273
487 488 F RXA01069 GR00299 606 4 489 490 RXN01071 VV0030 4879 2816
491 492 F RXA02898 GR10040 1631 6 493 494 F RXA01071 GR00299 2822
2436 495 496 RXN01075 VV0084 42045 41635 497 498 F RXA01075 GR00300
3269 2859 499 500 RXN01128 VV0157 2427 3440 501 502 F RXA01128
GR00314 1325 312 503 504 RXN01134 VV0077 774 4 505 506 F RXA01134
GR00317 2 460 507 508 RXN01140 VV0077 1642 710 509 510 F RXA01140
GR00318 3272 4057 511 512 RXN01148 VV0136 3147 3746 513 514 F
RXA01148 GR00323 1452 2051 515 516 RXN01153 VV0265 546 4 517 518 F
RXA01153 GR00325 546 4 519 520 RXN01154 VV0266 644 6 521 522 F
RXA01154 GR00326 608 6 523 524 RXN01155 VV0225 252 1721 525 526 F
RXA01155 GR00327 1370 6 527 528 RXN01167 VV0117 12777 13172 529 530
F RXA01167 GR00333 3 323 531 532 RXN01169 VV0117 5804 6799 533 534
F RXA01169 GR00334 1 567 535 536 RXN01173 VV0117 11085 10471 537
538 F RXA01173 GR00334 4853 4239 539 540 RXN01174 VV0117 12236
11487 541 542 F RXA01174 GR00334 6004 5255 543 544 RXN01229 VV0020
32482 31205 545 546 F RXA01229 GR00355 2806 3498 547 548 RXN01246
VV0104 2815 3321 549 550 F RXA01246 GR00360 1824 2462 551 552
RXN01249 VV0271 1 553 554 F RXA01249 GR00363 303 4 555 556 RXN01251
VV0219 13143 12835 557 558 F RXA01251 GR00365 228 536 559 560
RXN01263 VV0009 11816 12727 561 562 F RXA01263 GR00367 10720 11631
563 564 RXN01266 VV0009 15553 14519 565 566 F RXA01266 GR00367
14457 13423 567 568 RXN01275 VV0009 29514 30431 569 570 F RXA01275
GR00367 28418 29335 571 572 RXN01281 VV0212 4506 5267 573 574 F
RXA01281 GR00369 3869 4630 575 576 RXN01296 VV0209 10462 9380 577
578 F RXA01296 GR00373 5836 4754 579 580 RXN01306 VV0148 8158 7151
581 582 F RXA01306 GR00376 5691 4684 583 584 RXN01324 VV0082 6588
6887 585 586 RXN01331 VV0005 39816 42212 587 588 F RXA01331 GR00387
1606 1031 589 590 F RXA00668 GR00176 797 6 591 592 F RXA00674
GR00177 755 6 593 594 RXN01337 VV0032 1925 3337 595 596 F RXA01337
GR00389 5065 3653 597 598 RXN01351 VV0123 2841 3425 599 600
RXN01362 VV0051 27040 23387 601 602 F RXA01362 GR00395 3 1397 603
604 F RXA01364 GR00396 1869 4 605 606 RXN01379 VV0091 10518 11459
607 608 F RXA01379 GR00402 926 6 609 610 RXN01390 VV0277 6654 7310
611 612 F RXA01390 GR00408 992 336 613 614 RXN01391 VV0277 5568
6257 615 616 F RXA01391 GR00408 2078 1389 617 618 RXN01400 VV0126
2988 1489 619 620 F RXA01400 GR00409 2988 1489 621 622 RXN01409
VV0278 5304 4483 623 624 F RXA01409 GR00410 5296 4481 625 626
RXN01434 VV0050 13792 10841 627 628 F RXA01434 GR00417 10228 9863
629 630 RXN01448 VV0089 9602 10768 631 632 F RXA01448 GR00418 19796
19017 633 634 RXN01459 VV0233 3311 4120 635 636 F RXA01459 GR00420
3311 4120 637 638 RXN01460 VV0233 4066 4359 639 640 F RXA01460
GR00420 4066 4359 641 642 RXN01471 VV0019 11467 10661 643 644 F
RXA01471 GR00422 5243 4437 645 646 RXN01479 VV0019 18635 18874 647
648 F RXA01479 GR00422 12423 12650 649 650 RXN01484 VV0019 26292
25747 651 652 F RXA01484 GR00422 20068 19523 653 654 RXN01485
VV0019 26454 28505 655 656 F RXA01485 GR00422 20230 22281 657 658
RXN01492 VV0139 36004 36807 659 660 F RXA01492 GR00423 6133 5330
661 662 RXN01518 VV0008 23238 23711 663 664 F RXA01518 GR00424
23238 23711 665 666 RXN01549 VV0080 46 1704 667 668 F RXA01549
GR00430 8426 7566 669 670 F RXA02011 GR00603 46 363 671 672
RXN01557 VV0323 959 1774 673 674 F RXA01557 GR00433 959 1774 675
676 RXN01574 VV0009 48980 47946 677 678 F RXA01574 GR00438 6963
5929 679 680 RXN01589 VV0227 1216 197 681 682 RXN01592 VV0229 14706
13405 683 684 F RXA01592 GR00447 3 1295 685 686 RXN01597 VV0229
8480 7299 687 688 F RXA01597 GR00447 6220 7401 689 690 RXN01598
VV0229 7286 6324 691 692 F RXA01598 GR00447 7414 8376 693 694
RXN01618 VV0050 23629 23246 695 696 F RXA01618 GR00451 1387 1004
697 698 RXN01634 VV0050 43466 42915 699 700 F RXA01634 GR00454 4988
5539 701 702 RXN01635 VV0050 42879 42139 703 704 F RXA01635 GR00454
5575 6315 705 706 RXN01647 VV0005 43276 44445 707 708 F RXA01647
GR00456 12422 11535 709 710 RXN01658 VV0010 44183 42351 711 712 F
RXA01658 GR00461 5 1489 713 714 RXN01659 VV0089 5059 5604 715 716 F
RXA01659 GR00462 3 488 717 718 RXN01663 VV0089 4271 5128 719 720 F
RXA01663 GR00463 438 4 721 722 RXN01669 VV0057 4529 5443 723 724 F
RXA01669 GR00465 1002 271 725 726 RXN01672 VV0179 7849 8190 727 728
F RXA01672 GR00467 2 310 729 730 RXN01694 VV0139 13054 13953 731
732 F RXA01694 GR00474 3931 3032 733 734 RXN01696 VV0115 1381 203
735 736 F RXA01696 GR00475 799 203 737 738 RXN01697 VV0139 1581 625
739 740 F RXA01697 GR00476 761 1486 741 742 RXN01701 VV0162 375 4
743 744 F RXA01701 GR00478 196 528 745 746 RXN01703 VV0089 7108
8220 747 748 F RXA01703 GR00479 2118 1648 749 750 RXN01709 VV0022
847 416 751 752 F RXA01709 GR00483 745 416 753 754 RXN01711 VV0191
8153 6996 755 756 F RXA01711 GR00484 2007 850 757 758 RXN01721
VV0036 1026 4 759 760 RXN01734 VV0221 1251 1784 761 762 F RXA01734
GR00492 544 1077 763 764 RXN01742 VV0233 5246 4743 765 766 F
RXA01742 GR00493 7614 8117 767 768 RXN01754 VV0127 38790 36850 769
770 F RXA01754 GR00497 4082 2142 771 772 RXN01761 VV0010 11968 7505
773 774 F RXA00739 GR00202 819 4 775 776 F RXA01587 GR00442 120
2102 777 778 F RXA01761 GR00499 7001 5484 779 780 RXN01765 VV0054
17190 18131 781 782 F RXA01765 GR00500 3144 4085 783 784 RXN01767
VV0015 55242 55706 785 786 F RXA01767 GR00501 341 6 787 788
RXN01769 VV0015 54296 54736 789 790 F RXA01769 GR00501 1275 847 791
792 RXN01771 VV0050 35063 35764 793 794 F RXA01771 GR00502 886 185
795 796 RXN01774 VV0015 1794 2519 797 798 F RXA01774 GR00503 634
1416 799 800 RXN01787 VV0039 256 948 801 802 F RXA01787 GR00506 2
355 803 804 RXN01796 VV0137 2070 2843 805 806 F RXA01796 GR00508 2
484 807 808 RXN01803 VV0216 3355 4314 809 810 F RXA01803 GR00509
5671 4712 811 812 RXN01809 VV0081 9171 10346 813 814 F RXA01062
GR00297 490 5 815 816 F RXA01809 GR00510 3 638 817 818 RXN01811
VV0146 1243 1923 819 820 RXN01813 VV0084 46618 45953 821 822 F
RXA01813 GR00515 635 6 823 824 RXN01815 VV0084 49277 50068 825 826
F RXA01815 GR00515 3294 4085 827 828 RXN01825 VV0083 2847 2578 829
830 F RXA01825 GR00516 2847 2578 831 832 RXN01831 VV0083 10874
10413 833 834 F RXA01831 GR00516 10874 10413 835 836 RXN01834
VV0143 11244 11945 837 838 F RXA01834 GR00517 2478 1777 839 840
RXN01846 VV0010 287 6 841 842 F RXA01846 GR00523 261 4 843 844
RXN01847 VV0139 19018 18284 845 846 F RXA01847 GR00524 52 786 847
848 RXN01874 VV0248 352 5 849 850 F RXA01874 GR00535 2556 2903 851
852 RXN01875 VV0145 2894 2049 853 854 F RXA01875 GR00536 516 1313
855 856 F RXA02734 GR00762 6514 6897 857 858 RXN01877 VV0105 3493
2423 859 860 F RXA01877 GR00537 135 1199 861 862 RXN01879 VV0105
1505 573 863 864 F RXA01879 GR00537 2117 2704 865 866 F RXA01880
GR00537 2641 3048 867 868 RXN01896 VV0098 75888 76523 869 870 F
RXA01896 GR00544 2 580 871 872 RXN01899 VV0098 77817 78602 873 874
F RXA01899 GR00544 1874 2659 875 876 RXN01902 VV0098 84095 83037
877 878 F RXA01902 GR00544 7957 7094 879 880 RXN01908 VV0187 4030
4875 881 882 F RXA01908 GR00545 4030 4512 883 884 RXN01909 VV0218
69 947 885 886 F RXA01909 GR00546 59 937 887 888 RXN01910 VV0218
1040 1885 889 890 F RXA01910 GR00546 1030 1875 891 892 RXN01911
VV0218 2209 3147 893 894 F RXA01911 GR00546 2199 3044 895 896
RXN01930 VV0127 46545 47495 897 898 F RXA01930 GR00555 3817 2867
899 900 RXN01944 VV0050 42128 41157 901 902 F RXA01944 GR00558 2
385 903 904 F RXA01636 GR00454 6326 6898 905 906 RXN01945 VV0050
41150 39159 907 908 F RXA01945 GR00558 392 1633 909 910 F RXA01627
GR00453 1 495 911 912 RXN01960 VV0200 2259 1942 913 914 F RXA01960
GR00565 187 504 915 916 RXN01985 VV0056 1331 282 917 918 RXN01987
VV0149 167 379 919 920 F RXA01987 GR00576 167 379 921 922 RXN01988
VV0149 887 462 923 924 F RXA01988 GR00576 779 462 925 926 RXN01991
VV0230 926 1798 927 928 F RXA01991 GR00581 926 1720 929 930
RXN01996 VV0174 28434 27898 931 932 F RXA01996 GR00585 88 624 933
934 RXN02007 VV0324 855 223 935 936 F RXA02007 GR00598 651 223 937
938 RXN02014 VV0137 8298 8804 939 940 F RXA02014 GR00607 935 540
941 942 RXN02019 VV0129 44705 44205 943 944 F RXA02019 GR00612 597
106 945 946 RXN02023 VV0160 3234 4001 947 948 F RXA02023 GR00613
3234 4001 949 950 RXN02032 VV0117 5181 5750 951 952 F RXA02032
GR00618 4160 4729 953 954 RXN02039 VV0190 1482 643 955 956 F
RXA02039 GR00621 3 812 957 958 RXN02044 VV0025 17208 15826 959 960
RXN02045 VV0025 15823 15563 961 962 F RXA02045 GR00623 1913 2173
963 964 RXN02049 VV0009 35549 36157 965 966 F RXA02049 GR00624 1583
2029 967 968 RXN02050 VV0009 36003 36797 969 970 F RXA02050 GR00624
2462 2833 971 972 RXN02059 VV0222 10306 10800 973 974 F RXA02059
GR00625 4678 4184 975 976 RXN02066 VV0222 6187 6678 977 978 F
RXA02066 GR00626 6187 6678 979 980 RXN02067 VV0222 6733 7188 981
982 F RXA02067 GR00626 6733 7188 983 984 RXN02075 VV0318 12990
13778
985 986 RXN02076 VV0318 13879 14412 987 988 F RXA02076 GR00628 6902
7435 989 990 RXN02094 VV0126 18268 18984 991 992 F RXA02094 GR00629
13282 13998 993 994 RXN02104 VV0318 7435 6314 995 996 F RXA02104
GR00631 5327 4908 997 998 F RXA02071 GR00628 458 6 999 1000
RXN02107 VV0123 21585 21244 1001 1002 F RXA02107 GR00632 1536 1877
1003 1004 RXN02108 VV0123 21217 20609 1005 1006 F RXA02108 GR00632
2077 2511 1007 1008 RXN02114 VV0180 3 1009 1010 F RXA02114 GR00634
615 130 1011 1012 RXN02121 VV0102 12833 12129 1013 1014 F RXA02121
GR00636 5813 5109 1015 1016 RXN02138 VV0300 4409 4750 1017 1018 F
RXA02138 GR00639 4409 4750 1019 1020 RXN02151 VV0300 19913 21100
1021 1022 F RXA02151 GR00639 19913 21100 1023 1024 RXN02169 VV0100
3172 4017 1025 1026 F RXA02169 GR00641 3172 4017 1027 1028 RXN02180
VV0100 16813 15356 1029 1030 F RXA02180 GR00641 16813 15356 1031
1032 RXN02185 VV0100 20185 20763 1033 1034 F RXA02185 GR00641 20185
20763 1035 1036 RXN02186 VV0100 21192 20995 1037 1038 F RXA02186
GR00641 21213 20995 1039 1040 RXN02207 VV0302 802 5 1041 1042 F
RXA02207 GR00646 10909 11667 1043 1044 RXN02223 VV0308 2732 3232
1045 1046 F RXA02223 GR00652 425 6 1047 1048 RXN02226 VV0068 1059 4
1049 1050 F RXA02226 GR00653 1059 4 1051 1052 RXN02238 VV0204 1345
1629 1053 1054 F RXA02238 GR00654 5241 5525 1055 1056 RXN02254
VV0202 2 1057 1058 F RXA02254 GR00654 21769 22449 1059 1060
RXN02271 VV0020 14281 14838 1061 1062 F RXA02271 GR00655 5406 5963
1063 1064 RXN02279 VV0020 236 1693 1065 1066 F RXA02279 GR00657 1
1404 1067 1068 RXN02296 VV0127 24138 24626 1069 1070 F RXA02296
GR00662 6978 7466 1071 1072 RXN02300 VV0127 28354 28022 1073 1074 F
RXA02300 GR00662 11194 10862 1075 1076 RXN02301 VV0127 29070 28354
1077 1078 F RXA02301 GR00662 11910 11194 1079 1080 RXN02302 VV0127
29196 30074 1081 1082 F RXA02302 GR00662 12036 12800 1083 1084
RXN02303 VV0127 13326 14231 1085 1086 F RXA02303 GR00663 1 720 1087
1088 RXN02307 VV0127 12611 11991 1089 1090 F RXA02307 GR00664 395 6
1091 1092 RXN02314 VV0025 23092 23532 1093 1094 F RXA02314 GR00665
6379 5939 1095 1096 RXN02337 VV0141 4679 3357 1097 1098 F RXA02337
GR00672 2893 3816 1099 1100 RXN02339 VV0195 1 1101 1102 F RXA02339
GR00674 1 492 1103 1104 RXN02340 VV0195 1640 576 1105 1106 F
RXA02338 GR00673 484 5 1107 1108 F RXA02340 GR00674 1214 576 1109
1110 RXN02341 VV0078 4279 4764 1111 1112 F RXA02341 GR00675 415 5
1113 1114 RXN02360 VV0051 14638 12206 1115 1116 F RXA02360 GR00685
3644 6076 1117 1118 RXN02361 VV0051 12122 11472 1119 1120 F
RXA02361 GR00685 6160 6810 1121 1122 RXN02367 VV0102 4639 5247 1123
1124 F RXA02367 GR00687 2162 1554 1125 1126 RXN02368 VV0102 3883
4557 1127 1128 F RXA02368 GR00687 2918 2244 1129 1130 RXN02381
VV0213 3765 2743 1131 1132 F RXA02381 GR00691 1792 770 1133 1134
RXN02383 VV0213 639 4 1135 1136 F RXA02383 GR00692 608 6 1137 1138
RXN02387 VV0176 2729 3490 1139 1140 F RXA02387 GR00694 683 6 1141
1142 RXN02398 VV0176 12750 11149 1143 1144 F RXA02398 GR00698 2841
4370 1145 1146 RXN02406 VV0084 22016 22564 1147 1148 F RXA02406
GR00701 1322 774 1149 1150 RXN02407 VV0084 21758 21387 1151 1152 F
RXA02407 GR00701 1580 1885 1153 1154 RXN02408 VV0084 20832 19921
1155 1156 F RXA02408 GR00702 832 5 1157 1158 RXN02409 VV0084 21371
20835 1159 1160 F RXA02409 GR00702 1248 835 1161 1162 RXN02428
VV0110 4585 3452 1163 1164 F RXA02428 GR00707 4585 3452 1165 1166
RXN02454 VV0196 2810 1569 1167 1168 F RXA02454 GR00711 3 815 1169
1170 RXN02457 VV0124 19193 18084 1171 1172 F RXA02457 GR00712 1295
2404 1173 1174 RXN02460 VV0124 14649 15152 1175 1176 F RXA02460
GR00712 5839 5336 1177 1178 RXN02464 VV0211 1990 3189 1179 1180 F
RXA02464 GR00713 1107 1613 1181 1182 RXN02465 VV0211 3590 3192 1183
1184 F RXA02465 GR00713 2014 1616 1185 1186 RXN02466 VV0211 92 6
1187 1188 F RXA02466 GR00714 92 6 1189 1190 RXN02505 VV0007 23969
24139 1191 1192 F RXA02505 GR00720 18423 18593 1193 1194 RXN02510
VV0171 17467 16832 1195 1196 F RXA02510 GR00721 1983 2618 1197 1198
RXN02519 VV0183 2709 4337 1199 1200 F RXA02519 GR00724 1933 128
1201 1202 RXN02520 VV0183 2243 1560 1203 1204 F RXA02520 GR00724
2222 2905 1205 1206 RXN02534 VV0057 11192 11995 1207 1208 F
RXA02534 GR00726 5536 6339 1209 1210 RXN02537 VV0057 14617 15078
1211 1212 F RXA02537 GR00726 8961 9422 1213 1214 RXN02538 VV0057
15078 15749 1215 1216 F RXA02538 GR00726 9422 10093 1217 1218
RXN02555 VV0101 5340 4738 1219 1220 F RXA02555 GR00731 1757 1155
1221 1222 RXN02564 VV0154 10016 9015 1223 1224 F RXA02564 GR00732
2543 3217 1225 1226 RXN02568 VV0245 1657 5 1227 1228 F RXA02568
GR00735 1363 5 1229 1230 RXN02593 VV0098 11073 11669 1231 1232 F
RXA02593 GR00741 18693 18481 1233 1234 F RXA02594 GR00741 19077
18754 1235 1236 RXN02606 VV0098 34557 35927 1237 1238 F RXA02606
GR00742 13514 12144 1239 1240 RXN02610 VV0098 31620 30694 1241 1242
F RXA02610 GR00742 16452 17378 1243 1244 RXN02624 VV0129 29202
30497 1245 1246 F RXA02624 GR00746 5602 4889 1247 1248 RXN02626
VV0314 2012 1008 1249 1250 RXN02656 VV0090 15756 14917 1251 1252
RXN02673 VV0315 14030 13398 1253 1254 F RXA02673 GR00753 14030
13398 1255 1256 RXN02680 VV0098 64917 66200 1257 1258 F RXA02680
GR00754 6392 5109 1259 1260 F RXA02679 GR00754 5268 5693 1261 1262
F RXA02681 GR00754 5751 6194 1263 1264 RXN02693 VV0098 74100 75875
1265 1266 F RXA02693 GR00755 1650 4 1267 1268 RXN02696 VV0017 7946
7491 1269 1270 F RXA02696 GR00756 742 287 1271 1272 RXN02697 VV0017
31257 32783 1273 1274 F RXA02697 GR00757 1 699 1275 1276 F RXA02719
GR00758 19598 20245 1277 1278 RXN02720 VV0017 8727 8026 1279 1280 F
RXA02720 GR00759 631 5 1281 1282 RXN02744 VV0074 893 1696 1283 1284
F RXA02744 GR00763 14460 13657 1285 1286 RXN02770 VV0171 4202 2637
1287 1288 F RXA02770 GR00772 3 1322 1289 1290 RXN02781 VV0084 14566
13376 1291 1292 F RXA02781 GR00774 1345 155 1293 1294 RXN02782
VV0093 7148 8446 1295 1296 F RXA02782 GR00775 204 875 1297 1298
RXN02812 VV0210 342 4 1299 1300 F RXA02812 GR00793 2 568 1301 1302
RXN02817 VV0346 403 5 1303 1304 F RXA02817 GR00798 403 5 1305 1306
RXN02818 VV0347 611 6 1307 1308 F RXA02818 GR00799 611 6 1309 1310
RXN02825 VV0082 3589 1751 1311 1312 F RXA01322 GR00385 443 6 1313
1314 F RXA02824 GR00805 531 4 1315 1316 F RXA02825 GR00806 565 182
1317 1318 RXN02838 VV0161 1 1319 1320 F RXA02838 GR00831 1 462 1321
1322 RXN02840 VV0365 488 339 1323 1324 F RXA02840 GR00835 488 339
1325 1326 RXN02841 VV0055 11788 12222 1327 1328 F RXA02841 GR00840
283 5 1329 1330 RXN02846 VV0127 30861 30112 1331 1332 F RXA02846
GR00845 578 6 1333 1334 RXN02847 VV0113 47 1135 1335 1336 F
RXA02847 GR00847 598 5 1337 1338 RXN02849 VV0237 2 1339 1340 F
RXA02849 GR00849 2 283 1341 1342 RXN02911 VV0135 24643 25101 1343
1344 RXN02914 VV0127 17305 16763 1345 1346 RXN02921 VV0213 1871
1401 1347 1348 RXN02924 VV0088 4557 5105 1349 1350 RXN02927 VV0082
18836 19303 1351 1352 RXN02928 VV0082 19511 20203 1353 1354
RXN02931 VV0090 25420 25644 1355 1356 RXN02932 VV0176 23391 24362
1357 1358 RXN02934 VV0103 14533 14838 1359 1360 RXN02936 VV0197
24360 24557 1361 1362 RXN02939 VV0008 33988 32387 1363 1364 F
RXA01383 GR00406 1147 5 1365 1366 RXN02950 VV0224 7629 7306 1367
1368 RXN02951 VV0176 5739 5131 1369 1370 RXN02957 VV0020 30448
30158 1371 1372 RXN02967 VV0318 6614 6931 1373 1374 RXN02971 VV0210
951 640 1375 1376 RXN02978 VV0010 2191 683 1377 1378 RXN02995
VV0069 348 1913 1379 1380 RXN02997 VV0069 3709 2981 1381 1382
RXN03001 VV0170 422 874 1383 1384 RXN03005 VV0237 1101 334 1385
1386 RXN03009 VV0238 353 6 1387 1388 RXN03010 VV0238 7435 7199 1389
1390 RXN03011 VV0098 2984 3184 1391 1392 RXN03012 VV0241 2 571 1393
1394 RXN03017 VV0218 5720 7258 1395 1396 F RXA02753 GR00765 2630
138 1397 1398 RXN03018 VV0218 7221 8213 1399 1400 RXN03024 VV0003
6315 7730 1401 1402 RXN03025 VV0003 8668 7796 1403 1404 RXN03027
VV0008 17 151 1405 1406 RXN03029 VV0009 95 607 1407 1408 RXN03031
VV0011 1 789 1409 1410 RXN03032 VV0012 3652 3936 1411 1412 RXN03034
VV0013 2 661 1413 1414 F RXA00063 GR00010 1658 1374 1415 1416
RXN03037 VV0015 5364 5549 1417 1418 RXN03041 VV0018 1770 1273 1419
1420 F RXA02892 GR10035 1171 668 1421 1422 RXN03045 VV0019 33044
34039 1423 1424 RXN03046 VV0020 1 336 1425 1426 RXN03047 VV0020
25070 26485 1427 1428 F RXA00036 GR00004 7204 8619 1429 1430
RXN03048 VV0020 27423 26551 1431 1432 F RXA00037 GR00004 9557 8685
1433 1434 RXN03050 VV0021 6368 7333 1435 1436 RXN03053 VV0026 12
1535 1437 1438 F RXA02885 GR10021 1 1536 1439 1440 RXN03055 VV0026
3519 3947 1441 1442 F RXA00261 GR00039 11693 11265 1443 1444 F
RXA02888 GR10024 326 754 1445 1446 RXN03059 VV0030 5373 4894 1447
1448 F RXA02899 GR10040 2125 1646 1449 1450 RXN03062 VV0035 525 4
1451 1452 RXN03066 VV0038 7298 6636 1453 1454 F RXA02876 GR10016
405 1067 1455 1456 RXN03067 VV0038 7493 7323 1457 1458 RXN03068
VV0038 7648 7529 1459 1460 RXN03073 VV0042 1573 944 1461 1462 F
RXA02905 GR10044 477 4 1463 1464 RXN03085 VV0048 4511 4161 1465
1466 RXN03089 VV0053 1183 26 1467 1468 F RXA00071 GR00011 4013 5464
1469 1470 RXN03098 VV0064 2100 2723 1471 1472 RXN03099 VV0064 5576
6250 1473 1474 RXN03104 VV0071 401 577 1475 1476 RXN03106 VV0074
15930 16121 1477 1478 RXN03107 VV0076 232 432 1479 1480 RXN03113
VV0086 6541 8139 1481 1482 F RXA00506 GR00126 489 1829 1483 1484
RXN03115 VV0089 148 546 1485 1486 RXN03122 VV0104 3329 3475
1487 1488 RXN03134 VV0127 65312 65662 1489 1490 RXN03135 VV0127
66674 67402 1491 1492 F RXA02285 GR00660 1544 2272 1493 1494
RXN03138 VV0129 21194 21664 1495 1496 RXN03140 VV0131 4550 4302
1497 1498 RXN03141 VV0135 31144 31473 1499 1500 RXN03146 VV0143
25998 26468 1501 1502 RXN03147 VV0144 2726 2977 1503 1504 RXN03149
VV0146 969 1235 1505 1506 RXN03152 VV0166 264 536 1507 1508
RXN03153 VV0176 46481 47044 1509 1510 RXN03154 VV0179 1328 2239
1511 1512 RXN03156 VV0187 4908 5087 1513 1514 F RXA00176 GR00027
3475 3317 1515 1516 RXN03162 VV0195 909 1304 1517 1518 RXN03167
VV0327 633 4 1519 1520 F RXA02862 GR10006 1695 2330 1521 1522
RXN03170 VV0328 457 209 1523 1524 F RXA02856 GR10003 459 211 1525
1526 RXN03172 VV0329 1392 367 1527 1528 F RXA02858 GR10004 1392 367
1529 1530 RXN03173 VV0330 1340 243 1531 1532 F RXA02874 GR10015
1348 869 1533 1534 RXN03174 VV0331 461 6 1535 1536 F RXA02884
GR10020 1695 2156 1537 1538 RXN03177 VV0333 816 151 1539 1540 F
RXA02881 GR10019 94 759 1541 1542 RXN03182 VV0339 276 4 1543 1544
RXN03184 VV0374 517 20 1545 1546 RXN03185 VV0375 311 123 1547 1548
RXA00003 GR00001 2279 3019 1549 1550 RXA00008 GR00002 606 115 1551
1552 RXA00015 GR00002 5999 6307 1553 1554 RXA00018 GR00002 12979
14277 1555 1556 RXA00020 GR00002 17142 16363 1557 1558 RXA00021
GR00002 18766 20538 1559 1560 RXA00025 GR00003 2211 3647 1561 1562
RXA00031 GR00003 10383 9982 1563 1564 RXA00049 GR00008 2270 2956
1565 1566 RXA00052 GR00008 7957 7247 1567 1568 RXA00054 GR00008
8557 11469 1569 1570 RXA00058 GR00009 7394 6831 1571 1572 RXA00059
GR00009 8301 8020 1573 1574 RXA00065 GR00010 4140 4412 1575 1576
RXA00068 GR00011 1305 724 1577 1578 RXA00079 GR00012 6599 6820 1579
1580 RXA00082 GR00012 9019 8456 1581 1582 RXA00083 GR00013 771 1070
1583 1584 RXA00093 GR00014 204 2426 1585 1586 RXA00101 GR00014
10514 10107 1587 1588 RXA00108 GR00015 546 4 1589 1590 RXA00110
GR00016 364 912 1591 1592 RXA00117 GR00019 791 201 1593 1594
RXA00118 GR00019 918 1172 1595 1596 RXA00119 GR00019 1704 2462 1597
1598 RXA00121 GR00019 3473 4183 1599 1600 RXA00122 GR00019 4220
5842 1601 1602 RXA00127 GR00020 2871 2416 1603 1604 RXA00134
GR00021 1648 1079 1605 1606 RXA00140 GR00022 3841 3656 1607 1608
RXA00141 GR00022 4307 3846 1609 1610 RXA00142 GR00022 4776 4300
1611 1612 RXA00150 GR00023 4085 4858 1613 1614 RXA00151 GR00023
4956 5552 1615 1616 RXA00153 GR00023 7656 7231 1617 1618 RXA00155
GR00023 8615 9397 1619 1620 RXA00159 GR00024 3868 2687 1621 1622
RXA00161 GR00024 4893 5354 1623 1624 RXA00169 GR00026 5222 3150
1625 1626 RXA00170 GR00026 9914 8061 1627 1628 RXA00173 GR00027
1716 1384 1629 1630 RXA00174 GR00027 2079 1795 1631 1632 RXA00175
GR00027 2732 2103 1633 1634 RXA00179 GR00028 1714 1256 1635 1636
RXA00180 GR00028 2334 1795 1637 1638 RXA00183 GR00028 7344 8195
1639 1640 RXA00185 GR00028 9418 12045 1641 1642 RXA00199 GR00031
2172 754 1643 1644 RXA00200 GR00031 2837 2535 1645 1646 RXA00207
GR00032 6430 6747 1647 1648 RXA00211 GR00032 10120 10782 1649 1650
RXA00218 GR00032 18104 19243 1651 1652 RXA00220 GR00032 20666 20163
1653 1654 RXA00230 GR00034 746 27 1655 1656 RXA00233 GR00036 420 4
1657 1658 RXA00234 GR00036 998 459 1659 1660 RXA00237 GR00036 3668
4045 1661 1662 RXA00238 GR00036 4186 4554 1663 1664 RXA00239
GR00036 5118 4534 1665 1666 RXA00240 GR00036 5342 5133 1667 1668
RXA00244 GR00037 1565 930 1669 1670 RXA00245 GR00037 3049 1565 1671
1672 RXA00248 GR00037 7843 7121 1673 1674 RXA00250 GR00038 6 221
1675 1676 RXA00252 GR00038 485 727 1677 1678 RXA00257 GR00039 1760
2215 1679 1680 RXA00258 GR00039 3219 3890 1681 1682 RXA00260
GR00039 9234 10409 1683 1684 RXA00273 GR00042 185 1297 1685 1686
RXA00274 GR00042 1556 4165 1687 1688 RXA00275 GR00042 4696 4238
1689 1690 RXA00276 GR00042 5016 4675 1691 1692 RXA00279 GR00043
4001 2616 1693 1694 RXA00282 GR00044 793 5 1695 1696 RXA00285
GR00046 3 515 1697 1698 RXA00286 GR00046 579 1142 1699 1700
RXA00294 GR00047 2761 3189 1701 1702 RXA00297 GR00048 2861 3772
1703 1704 RXA00320 GR00057 358 537 1705 1706 RXA00321 GR00057 2411
597 1707 1708 RXA00322 GR00057 3658 2555 1709 1710 RXA00325 GR00057
8594 9238 1711 1712 RXA00326 GR00057 9378 9857 1713 1714 RXA00336
GR00057 19461 19931 1715 1716 RXA00337 GR00058 530 6 1717 1718
RXA00339 GR00059 817 1533 1719 1720 RXA00349 GR00066 3 1061 1721
1722 RXA00355 GR00069 635 510 1723 1724 RXA00375 GR00080 549 49
1725 1726 RXA00380 GR00082 836 216 1727 1728 RXA00387 GR00084 1403
591 1729 1730 RXA00392 GR00086 3890 3027 1731 1732 RXA00394 GR00086
5322 4990 1733 1734 RXA00395 GR00086 5417 5716 1735 1736 RXA00396
GR00086 6653 6183 1737 1738 RXA00397 GR00086 7206 6667 1739 1740
RXA00398 GR00087 1 681 1741 1742 RXA00408 GR00091 642 1088 1743
1744 RXA00409 GR00091 1088 2500 1745 1746 RXA00411 GR00092 1685
1011 1747 1748 RXA00423 GR00097 909 457 1749 1750 RXA00424 GR00097
1379 909 1751 1752 RXA00425 GR00097 1433 1657 1753 1754 RXA00428
GR00098 2657 2025 1755 1756 RXA00429 GR00098 3063 2662 1757 1758
RXA00430 GR00098 3473 3063 1759 1760 RXA00433 GR00100 1446 1970
1761 1762 RXA00451 GR00110 816 325 1763 1764 RXA00457 GR00114 1451
372 1765 1766 RXA00462 GR00116 3023 1644 1767 1768 RXA00463 GR00116
4209 3388 1769 1770 RXA00468 GR00118 1282 464 1771 1772 RXA00469
GR00119 1647 472 1773 1774 RXA00472 GR00119 5449 4589 1775 1776
RXA00474 GR00119 6575 8152 1777 1778 RXA00475 GR00119 8822 8163
1779 1780 RXA00476 GR00119 8961 9821 1781 1782 RXA00481 GR00119
17636 18220 1783 1784 RXA00486 GR00120 1 702 1785 1786 RXA00490
GR00121 2676 1774 1787 1788 RXA00491 GR00122 1057 638 1789 1790
RXA00493 GR00123 3 326 1791 1792 RXA00519 GR00132 4 516 1793 1794
RXA00528 GR00136 3562 4650 1795 1796 RXA00529 GR00136 5274 4732
1797 1798 RXA00530 GR00136 6837 5557 1799 1800 RXA00535 GR00137
5155 5871 1801 1802 RXA00540 GR00139 2027 2269 1803 1804 RXA00549
GR00143 502 897 1805 1806 RXA00550 GR00143 935 1255 1807 1808
RXA00553 GR00145 742 1062 1809 1810 RXA00554 GR00145 1606 1136 1811
1812 RXA00563 GR00151 1 2739 1813 1814 RXA00564 GR00151 3744 4148
1815 1816 RXA00573 GR00156 117 767 1817 1818 RXA00576 GR00156 2916
2245 1819 1820 RXA00577 GR00156 2980 3327 1821 1822 RXA00578
GR00156 4087 3365 1823 1824 RXA00582 GR00156 9442 8924 1825 1826
RXA00585 GR00156 11894 11577 1827 1828 RXA00586 GR00156 12818 11937
1829 1830 RXA00587 GR00156 13008 13490 1831 1832 RXA00595 GR00159 3
332 1833 1834 RXA00597 GR00159 797 1066 1835 1836 RXA00598 GR00159
1070 1387 1837 1838 RXA00601 GR00159 3459 3749 1839 1840 RXA00602
GR00159 4907 4155 1841 1842 RXA00604 GR00159 5489 5779 1843 1844
RXA00610 GR00161 1193 2056 1845 1846 RXA00611 GR00161 3640 2165
1847 1848 RXA00613 GR00162 1652 1200 1849 1850 RXA00614 GR00162
1680 2594 1851 1852 RXA00617 GR00162 4002 5084 1853 1854 RXA00628
GR00165 1284 877 1855 1856 RXA00631 GR00166 172 1626 1857 1858
RXA00637 GR00167 2002 2754 1859 1860 RXA00646 GR00169 446 6 1861
1862 RXA00649 GR00169 2823 3278 1863 1864 RXA00652 GR00169 5449
5997 1865 1866 RXA00654 GR00169 7213 8478 1867 1868 RXA00656
GR00169 9495 9235 1869 1870 RXA00657 GR00169 10882 9980 1871 1872
RXA00661 GR00172 664 1353 1873 1874 RXA00667 GR00175 593 1177 1875
1876 RXA00676 GR00178 647 1393 1877 1878 RXA00678 GR00179 1037 303
1879 1880 RXA00691 GR00181 2152 1223 1881 1882 RXA00692 GR00181
3450 2317 1883 1884 RXA00693 GR00181 4303 3821 1885 1886 RXA00701
GR00182 427 801 1887 1888 RXA00707 GR00185 377 1348 1889 1890
RXA00713 GR00188 71 1033 1891 1892 RXA00714 GR00188 1809 1249 1893
1894 RXA00716 GR00188 3002 3514 1895 1896 RXA00719 GR00188 5283
6911 1897 1898 RXA00724 GR00191 811 164 1899 1900 RXA00726 GR00192
841 701 1901 1902 RXA00740 GR00202 1646 1068 1903 1904 RXA00741
GR00202 2986 2054 1905 1906 RXA00742 GR00202 5517 3868 1907 1908
RXA00743 GR00202 6652 6230 1909 1910 RXA00745 GR00202 13874 13341
1911 1912 RXA00746 GR00202 13755 14945 1913 1914 RXA00747 GR00202
15067 15654 1915 1916 RXA00748 GR00202 15917 16360 1917 1918
RXA00749 GR00202 17240 16542 1919 1920 RXA00751 GR00202 20245 19418
1921 1922 RXA00752 GR00202 21847 21419 1923 1924 RXA00757 GR00203
3119 4372 1925 1926 RXA00763 GR00204 1384 2166 1927 1928 RXA00765
GR00204 3283 3969 1929 1930 RXA00781 GR00206 2682 2395 1931 1932
RXA00788 GR00209 910 686 1933 1934 RXA00804 GR00215 438 881 1935
1936 RXA00805 GR00215 2057 2938 1937 1938 RXA00808 GR00217 1029 352
1939 1940 RXA00812 GR00219 287 1345 1941 1942 RXA00814 GR00219 2463
3236 1943 1944 RXA00815 GR00219 3236 3808 1945 1946 RXA00816
GR00219 4382 4678 1947 1948 RXA00826 GR00223 567 37 1949 1950
RXA00830 GR00224 266 988 1951 1952 RXA00853 GR00231 3775 3173 1953
1954 RXA00861 GR00235 6 431 1955 1956 RXA00862 GR00236 580 17 1957
1958 RXA00874 GR00241 758 1846 1959 1960 RXA00876 GR00241 4208 2454
1961 1962 RXA00881 GR00242 8057 8434 1963 1964 RXA00882 GR00242
8788 9465 1965 1966 RXA00883 GR00242 10060 9542 1967 1968 RXA00887
GR00242 13544 14266 1969 1970 RXA00889 GR00242 15341 15928 1971
1972 RXA00893 GR00244 789 193 1973 1974 RXA00895 GR00244 2578 1988
1975 1976 RXA00904 GR00246 1457 702 1977 1978 RXA00908 GR00247 1611
2168 1979 1980 RXA00916 GR00251 4108 518 1981 1982 RXA00926 GR00253
466 104 1983 1984 RXA00930 GR00253 3841 3089 1985 1986 RXA00932
GR00253 5068 5541 1987 1988 RXA00933 GR00253 6047 5586
1989 1990 RXA00940 GR00257 129 524 1991 1992 RXA00949 GR00259 5400
6047 1993 1994 RXA00969 GR00273 1 147 1995 1996 RXA00973 GR00274
2272 1670 1997 1998 RXA00978 GR00276 217 831 1999 2000 RXA00986
GR00280 60 401 2001 2002 RXA00987 GR00280 875 411 2003 2004
RXA00988 GR00280 1371 949 2005 2006 RXA01005 GR00286 520 1365 2007
2008 RXA01007 GR00287 2572 866 2009 2010 RXA01008 GR00287 2719 4659
2011 2012 RXA01011 GR00288 2089 857 2013 2014 RXA01017 GR00290 2175
1567 2015 2016 RXA01021 GR00291 1759 2280 2017 2018 RXA01029
GR00295 1338 1826 2019 2020 RXA01031 GR00295 3182 3847 2021 2022
RXA01032 GR00295 3974 4348 2023 2024 RXA01033 GR00295 4363 4698
2025 2026 RXA01034 GR00295 5177 4824 2027 2028 RXA01035 GR00295
5818 6423 2029 2030 RXA01036 GR00295 6513 6965 2031 2032 RXA01037
GR00295 7000 7527 2033 2034 RXA01038 GR00295 7530 8276 2035 2036
RXA01039 GR00295 9540 8965 2037 2038 RXA01040 GR00295 9711 10613
2039 2040 RXA01041 GR00295 10780 10932 2041 2042 RXA01042 GR00295
11088 12365 2043 2044 RXA01043 GR00295 12774 13346 2045 2046
RXA01044 GR00295 14024 15280 2047 2048 RXA01045 GR00295 15407 17230
2049 2050 RXA01046 GR00295 17441 19219 2051 2052 RXA01047 GR00295
19244 19717 2053 2054 RXA01058 GR00296 8566 8246 2055 2056 RXA01063
GR00297 828 499 2057 2058 RXA01066 GR00298 605 1330 2059 2060
RXA01068 GR00298 2184 3254 2061 2062 RXA01074 GR00300 2811 2107
2063 2064 RXA01076 GR00300 4374 3355 2065 2066 RXA01078 GR00300
6043 6876 2067 2068 RXA01083 GR00302 1777 1502 2069 2070 RXA01088
GR00304 3083 1902 2071 2072 RXA01091 GR00305 546 76 2073 2074
RXA01092 GR00305 702 881 2075 2076 RXA01092 GR00305 702 881 2077
2078 RXA01096 GR00306 4341 3643 2079 2080 RXA01102 GR00306 10018
8774 2081 2082 RXA01103 GR00306 10316 10092 2083 2084 RXA01107
GR00306 13612 14811 2085 2086 RXA01108 GR00306 15562 14912 2087
2088 RXA01109 GR00306 16281 15640 2089 2090 RXA01119 GR00310 1068
139 2091 2092 RXA01122 GR00311 557 36 2093 2094 RXA01123 GR00311
1090 644 2095 2096 RXA01127 GR00314 2 280 2097 2098 RXA01129
GR00314 1461 3326 2099 2100 RXA01131 GR00315 445 1311 2101 2102
RXA01137 GR00318 1101 1460 2103 2104 RXA01156 GR00327 1588 1388
2105 2106 RXA01158 GR00328 2580 1639 2107 2108 RXA01159 GR00328
3089 2775 2109 2110 RXA01160 GR00328 4187 3213 2111 2112 RXA01163
GR00331 710 6 2113 2114 RXA01165 GR00332 2155 1583 2115 2116
RXA01166 GR00332 3005 2523 2117 2118 RXA01170 GR00334 638 1120 2119
2120 RXA01171 GR00334 1714 2406 2121 2122 RXA01176 GR00335 1980
1477 2123 2124 RXA01177 GR00335 2121 4106 2125 2126 RXA01178
GR00335 4106 4555 2127 2128 RXA01184 GR00338 1489 17 2129 2130
RXA01186 GR00338 3742 2645 2131 2132 RXA01186 GR00338 3742 2645
2133 2134 RXA01187 GR00338 3850 4308 2135 2136 RXA01195 GR00343
1413 1859 2137 2138 RXA01196 GR00343 1889 2578 2139 2140 RXA01197
GR00343 3333 2881 2141 2142 RXA01198 GR00343 3422 3724 2143 2144
RXA01207 GR00347 126 773 2145 2146 RXA01213 GR00351 1508 282 2147
2148 RXA01218 GR00353 1078 1506 2149 2150 RXA01234 GR00357 633 250
2151 2152 RXA01237 GR00358 2751 2311 2153 2154 RXA01267 GR00367
16799 15486 2155 2156 RXA01268 GR00367 19365 18526 2157 2158
RXA01271 GR00367 23467 21656 2159 2160 RXA01273 GR00367 26475 25042
2161 2162 RXA01282 GR00369 5444 4665 2163 2164 RXA01294 GR00373
3537 2872 2165 2166 RXA01295 GR00373 3764 4738 2167 2168 RXA01304
GR00376 1982 2467 2169 2170 RXA01310 GR00380 803 477 2171 2172
RXA01313 GR00381 1116 172 2173 2174 RXA01315 GR00382 1394 744 2175
2176 RXA01316 GR00382 1855 1553 2177 2178 RXA01317 GR00382 2296
1877 2179 2180 RXA01318 GR00382 3616 2315 2181 2182 RXA01330
GR00387 569 1024 2183 2184 RXA01333 GR00389 1231 227 2185 2186
RXA01336 GR00389 3640 3038 2187 2188 RXA01342 GR00389 11296 12807
2189 2190 RXA01348 GR00392 261 752 2191 2192 RXA01349 GR00392 1531
755 2193 2194 RXA01357 GR00393 4357 4659 2195 2196 RXA01359 GR00393
6857 8038 2197 2198 RXA01366 GR00397 1369 980 2199 2200 RXA01367
GR00397 1518 1919 2201 2202 RXA01370 GR00398 1875 2225 2203 2204
RXA01372 GR00399 1 591 2205 2206 RXA01378 GR00401 1281 4 2207 2208
RXA01380 GR00403 2 2017 2209 2210 RXA01384 GR00406 3238 1523 2211
2212 RXA01396 GR00408 6475 6218 2213 2214 RXA01397 GR00408 6894
6475 2215 2216 RXA01401 GR00409 3193 3453 2217 2218 RXA01402
GR00409 3508 3981 2219 2220 RXA01405 GR00410 1844 1389 2221 2222
RXA01413 GR00412 854 1453 2223 2224 RXA01414 GR00412 1628 2134 2225
2226 RXA01417 GR00414 645 49 2227 2228 RXA01421 GR00416 1215 829
2229 2230 RXA01425 GR00417 1701 2585 2231 2232 RXA01429 GR00417
5651 6268 2233 2234 RXA01439 GR00418 5949 6494 2235 2236 RXA01440
GR00418 7496 6489 2237 2238 RXA01441 GR00418 8542 7514 2239 2240
RXA01445 GR00418 15083 14091 2241 2242 RXA01447 GR00418 17885 18733
2243 2244 RXA01452 GR00419 2363 2641 2245 2246 RXA01456 GR00420 898
1419 2247 2248 RXA01457 GR00420 1499 2173 2249 2250 RXA01463
GR00421 2493 1330 2251 2252 RXA01469 GR00422 2091 3122 2253 2254
RXA01470 GR00422 4112 3687 2255 2256 RXA01472 GR00422 5783 5328
2257 2258 RXA01473 GR00422 6596 5832 2259 2260 RXA01474 GR00422
6678 7223 2261 2262 RXA01475 GR00422 7651 7226 2263 2264 RXA01476
GR00422 7847 8188 2265 2266 RXA01488 GR00423 2179 1349 2267 2268
RXA01494 GR00423 8515 7520 2269 2270 RXA01497 GR00424 262 1179 2271
2272 RXA01501 GR00424 8130 7843 2273 2274 RXA01504 GR00424 10710
11318 2275 2276 RXA01505 GR00424 11318 11815 2277 2278 RXA01506
GR00424 11815 12225 2279 2280 RXA01507 GR00424 12239 12661 2281
2282 RXA01519 GR00424 23725 24471 2283 2284 RXA01520 GR00424 24784
25167 2285 2286 RXA01523 GR00424 27951 28901 2287 2288 RXA01525
GR00424 32301 30580 2289 2290 RXA01527 GR00425 5126 2616 2291 2292
RXA01536 GR00427 4066 2825 2293 2294 RXA01540 GR00428 3083 2382
2295 2296 RXA01543 GR00430 2802 37 2297 2298 RXA01544 GR00430 3496
2897 2299 2300 RXA01545 GR00430 4838 3588 2301 2302 RXA01546
GR00430 5584 4889 2303 2304 RXA01547 GR00430 6371 5709 2305 2306
RXA01548 GR00430 7432 6425 2307 2308 RXA01552 GR00431 6122 5145
2309 2310 RXA01554 GR00432 3719 1578 2311 2312 RXA01560 GR00435 767
438 2313 2314 RXA01575 GR00438 8024 7005 2315 2316 RXA01577 GR00438
8811 9185 2317 2318 RXA01579 GR00439 671 1054 2319 2320 RXA01585
GR00441 1226 600 2321 2322 RXA01586 GR00441 1597 1229 2323 2324
RXA01595 GR00447 3326 4285 2325 2326 RXA01600 GR00447 10460 11128
2327 2328 RXA01602 GR00447 13591 12062 2329 2330 RXA01605 GR00448
960 2474 2331 2332 RXA01610 GR00449 4343 3615 2333 2334 RXA01611
GR00449 4832 4476 2335 2336 RXA01612 GR00449 5235 4891 2337 2338
RXA01619 GR00451 2407 1433 2339 2340 RXA01622 GR00452 1908 2510
2341 2342 RXA01623 GR00452 2514 3224 2343 2344 RXA01624 GR00452
3220 3564 2345 2346 RXA01628 GR00453 866 1879 2347 2348 RXA01630
GR00454 341 1417 2349 2350 RXA01641 GR00456 5182 6552 2351 2352
RXA01642 GR00456 6557 7798 2353 2354 RXA01643 GR00456 8374 7949
2355 2356 RXA01645 GR00456 10574 9969 2357 2358 RXA01646 GR00456
11513 10695 2359 2360 RXA01656 GR00460 1548 2444 2361 2362 RXA01665
GR00463 2152 1433 2363 2364 RXA01671 GR00466 854 1468 2365 2366
RXA01673 GR00467 1807 773 2367 2368 RXA01675 GR00467 2824 3234 2369
2370 RXA01676 GR00467 4179 3424 2371 2372 RXA01677 GR00467 5043
4300 2373 2374 RXA01681 GR00467 10681 11313 2375 2376 RXA01685
GR00470 1488 910 2377 2378 RXA01686 GR00470 2026 1586 2379 2380
RXA01693 GR00474 1553 2974 2381 2382 RXA01714 GR00485 985 371 2383
2384 RXA01715 GR00485 1267 1962 2385 2386 RXA01729 GR00489 2636
3154 2387 2388 RXA01731 GR00491 109 807 2389 2390 RXA01738 GR00493
3971 4684 2391 2392 RXA01741 GR00493 7535 6738 2393 2394 RXA01748
GR00495 3681 4460 2395 2396 RXA01749 GR00495 4633 6249 2397 2398
RXA01750 GR00496 1878 3518 2399 2400 RXA01752 GR00497 557 6 2401
2402 RXA01753 GR00497 2095 557 2403 2404 RXA01760 GR00498 5095 5376
2405 2406 RXA01768 GR00501 827 450 2407 2408 RXA01770 GR00501 5134
1370 2409 2410 RXA01773 GR00503 34 444 2411 2412 RXA01775 GR00504
178 741 2413 2414 RXA01776 GR00504 838 2289 2415 2416 RXA01777
GR00504 2319 2777 2417 2418 RXA01778 GR00504 2912 4048 2419 2420
RXA01779 GR00504 4246 5664 2421 2422 RXA01780 GR00504 5721 6095
2423 2424 RXA01781 GR00504 6052 6312 2425 2426 RXA01782 GR00504
6384 6779 2427 2428 RXA01783 GR00504 6842 7078 2429 2430 RXA01785
GR00505 729 1304 2431 2432 RXA01788 GR00506 361 801 2433 2434
RXA01789 GR00506 875 1516 2435 2436 RXA01790 GR00506 1672 1731 2437
2438 RXA01791 GR00506 1885 2247 2439 2440 RXA01792 GR00506 2310
2582 2441 2442 RXA01793 GR00506 2916 3149 2443 2444 RXA01794
GR00506 3194 3427 2445 2446 RXA01799 GR00509 377 1570 2447 2448
RXA01800 GR00509 2292 1573 2449 2450 RXA01804 GR00509 6117 5797
2451 2452 RXA01805 GR00509 6515 6186 2453 2454 RXA01806 GR00509
6595 7074 2455 2456 RXA01816 GR00515 4210 4941 2457 2458 RXA01817
GR00515 4941 5573 2459 2460 RXA01820 GR00515 8360 9733 2461 2462
RXA01842 GR00522 1397 480 2463 2464 RXA01844 GR00522 1950 1771 2465
2466 RXA01845 GR00522 1919 2326 2467 2468 RXA01856 GR00527 225 770
2469 2470 RXA01857 GR00527 939 1589 2471 2472 RXA01858 GR00529 578
6 2473 2474 RXA01870 GR00534 2123 2797 2475 2476 RXA01871 GR00534
2797 3759 2477 2478 RXA01903 GR00545 3 281 2479 2480 RXA01904
GR00545 762 340 2481 2482 RXA01905 GR00545 1074 1604 2483 2484
RXA01906 GR00545 2322 2786 2485 2486 RXA01907 GR00545 3176 3787
2487 2488 RXA01923 GR00552 1311 1739 2489 2490 RXA01931 GR00555
4913 5566
2491 2492 RXA01941 GR00557 995 1429 2493 2494 RXA01942 GR00557 3526
2927 2495 2496 RXA01957 GR00564 389 850 2497 2498 RXA01958 GR00564
910 1416 2499 2500 RXA01959 GR00564 1639 2019 2501 2502 RXA01961
GR00565 521 1000 2503 2504 RXA01962 GR00565 1022 1591 2505 2506
RXA01963 GR00565 1757 2440 2507 2508 RXA01964 GR00566 1329 4 2509
2510 RXA01965 GR00566 1935 1375 2511 2512 RXA01966 GR00567 47 703
2513 2514 RXA01968 GR00567 3295 2138 2515 2516 RXA01969 GR00567
5689 5216 2517 2518 RXA01973 GR00570 2 583 2519 2520 RXA01974
GR00570 658 2109 2521 2522 RXA01976 GR00571 3742 2222 2523 2524
RXA01977 GR00571 4547 3972 2525 2526 RXA01982 GR00573 3001 1844
2527 2528 RXA01990 GR00581 1 999 2529 2530 RXA01992 GR00583 709 260
2531 2532 RXA01999 GR00589 2384 2854 2533 2534 RXA02001 GR00590 700
152 2535 2536 RXA02004 GR00594 3 209 2537 2538 RXA02006 GR00597 498
4 2539 2540 RXA02009 GR00601 127 5 2541 2542 RXA02013 GR00607 553 5
2543 2544 RXA02021 GR00613 2008 1061 2545 2546 RXA02036 GR00619
3441 3821 2547 2548 RXA02040 GR00621 1452 925 2549 2550 RXA02046
GR00623 2680 2943 2551 2552 RXA02051 GR00624 3186 3683 2553 2554
RXA02053 GR00624 5484 6062 2555 2556 RXA02057 GR00625 2972 3502
2557 2558 RXA02058 GR00625 4051 3500 2559 2560 RXA02069 GR00627
1116 1694 2561 2562 RXA02070 GR00627 1733 2830 2563 2564 RXA02080
GR00628 11017 10211 2565 2566 RXA02081 GR00628 12307 13935 2567
2568 RXA02084 GR00629 2920 2576 2569 2570 RXA02089 GR00629 8431
8901 2571 2572 RXA02090 GR00629 9764 8964 2573 2574 RXA02091
GR00629 10512 9862 2575 2576 RXA02097 GR00630 184 3555 2577 2578
RXA02102 GR00631 4479 3322 2579 2580 RXA02103 GR00631 4510 4905
2581 2582 RXA02109 GR00632 3460 2540 2583 2584 RXA02117 GR00636
1056 1529 2585 2586 RXA02123 GR00636 6558 7928 2587 2588 RXA02124
GR00636 7956 9911 2589 2590 RXA02125 GR00637 739 1539 2591 2592
RXA02129 GR00637 5906 6139 2593 2594 RXA02132 GR00638 737 1375 2595
2596 RXA02137 GR00639 4166 3369 2597 2598 RXA02141 GR00639 8457
8864 2599 2600 RXA02146 GR00639 14742 15368 2601 2602 RXA02152
GR00640 237 638 2603 2604 RXA02163 GR00640 10072 10824 2605 2606
RXA02164 GR00640 10824 12398 2607 2608 RXA02165 GR00640 12388 12999
2609 2610 RXA02166 GR00640 13048 13224 2611 2612 RXA02168 GR00641
2894 81 2613 2614 RXA02170 GR00641 4798 4025 2615 2616 RXA02172
GR00641 6919 6581 2617 2618 RXA02177 GR00641 12683 13615 2619 2620
RXA02178 GR00641 13628 14497 2621 2622 RXA02181 GR00641 17168 17845
2623 2624 RXA02183 GR00641 18663 19187 2625 2626 RXA02187 GR00641
21249 23447 2627 2628 RXA02199 GR00646 2591 3160 2629 2630 RXA02203
GR00646 7469 7092 2631 2632 RXA02206 GR00646 9927 10862 2633 2634
RXA02211 GR00648 2537 2989 2635 2636 RXA02212 GR00649 964 467 2637
2638 RXA02216 GR00651 2 307 2639 2640 RXA02217 GR00651 968 306 2641
2642 RXA02218 GR00651 1299 1565 2643 2644 RXA02219 GR00651 1578
2963 2645 2646 RXA02221 GR00651 6720 8081 2647 2648 RXA02227
GR00653 1236 1853 2649 2650 RXA02230 GR00653 4156 3620 2651 2652
RXA02231 GR00653 5111 4356 2653 2654 RXA02244 GR00654 12058 13590
2655 2656 RXA02255 GR00654 22507 23442 2657 2658 RXA02266 GR00655
653 1165 2659 2660 RXA02267 GR00655 2053 1181 2661 2662 RXA02280
GR00658 2 754 2663 2664 RXA02286 GR00660 3285 3833 2665 2666
RXA02287 GR00660 4071 4622 2667 2668 RXA02294 GR00662 5992 5618
2669 2670 RXA02295 GR00662 6842 6063 2671 2672 RXA02297 GR00662
7502 8638 2673 2674 RXA02298 GR00662 10310 8652 2675 2676 RXA02304
GR00663 1613 723 2677 2678 RXA02308 GR00664 939 511 2679 2680
RXA02324 GR00668 1548 2633 2681 2682 RXA02325 GR00668 4314 3445
2683 2684 RXA02331 GR00671 396 761 2685 2686 RXA02336 GR00672 2731
2552 2687 2688 RXA02347 GR00677 509 189 2689 2690 RXA02349 GR00678
394 5 2691 2692 RXA02352 GR00681 2 556 2693 2694 RXA02356 GR00684
761 1756 2695 2696 RXA02358 GR00685 1239 1529 2697 2698 RXA02362
GR00685 7045 10743 2699 2700 RXA02374 GR00688 1626 2246 2701 2702
RXA02390 GR00695 1500 832 2703 2704 RXA02393 GR00697 168 449 2705
2706 RXA02395 GR00698 2 733 2707 2708 RXA02396 GR00698 1309 1031
2709 2710 RXA02403 GR00700 896 1660 2711 2712 RXA02412 GR00703 2043
2522 2713 2714 RXA02417 GR00705 4755 2632 2715 2716 RXA02421
GR00705 7237 6428 2717 2718 RXA02425 GR00707 1 630 2719 2720
RXA02427 GR00707 3447 3061 2721 2722 RXA02430 GR00707 7498 7683
2723 2724 RXA02433 GR00708 2981 3580 2725 2726 RXA02437 GR00709
1661 2470 2727 2728 RXA02443 GR00709 6818 7771 2729 2730 RXA02444
GR00709 7836 9113 2731 2732 RXA02452 GR00710 5271 5092 2733 2734
RXA02459 GR00712 4341 5075 2735 2736 RXA02461 GR00712 6252 5845
2737 2738 RXA02467 GR00714 643 419 2739 2740 RXA02472 GR00715 5435
5725 2741 2742 RXA02473 GR00715 6664 5924 2743 2744 RXA02475
GR00715 9595 8441 2745 2746 RXA02478 GR00716 1245 10 2747 2748
RXA02482 GR00718 914 105 2749 2750 RXA02483 GR00718 1813 1001 2751
2752 RXA02484 GR00718 2317 1817 2753 2754 RXA02486 GR00718 3441
4076 2755 2756 RXA02488 GR00719 1 369 2757 2758 RXA02489 GR00719
373 996 2759 2760 RXA02495 GR00720 9002 6435 2761 2762 RXA02496
GR00720 10025 9219 2763 2764 RXA02498 GR00720 11016 11819 2765 2766
RXA02500 GR00720 13460 13558 2767 2768 RXA02506 GR00720 19484 18603
2769 2770 RXA02514 GR00723 1 837 2771 2772 RXA02518 GR00723 3464
3874 2773 2774 RXA02521 GR00724 2924 4366 2775 2776 RXA02524
GR00725 2405 3094 2777 2778 RXA02525 GR00725 3113 3490 2779 2780
RXA02540 GR00726 12438 12001 2781 2782 RXA02544 GR00726 16715 18142
2783 2784 RXA02545 GR00726 18749 18192 2785 2786 RXA02546 GR00726
19927 18824 2787 2788 RXA02549 GR00728 1331 6 2789 2790 RXA02552
GR00730 924 130 2791 2792 RXA02554 GR00731 1050 427 2793 2794
RXA02569 GR00736 82 831 2795 2796 RXA02570 GR00736 837 1478 2797
2798 RXA02573 GR00739 594 151 2799 2800 RXA02575 GR00739 1907 3064
2801 2802 RXA02576 GR00740 1569 148 2803 2804 RXA02577 GR00740 2463
1579 2805 2806 RXA02584 GR00741 8925 8575 2807 2808 RXA02585
GR00741 9917 8937 2809 2810 RXA02588 GR00741 13037 12354 2811 2812
RXA02591 GR00741 15780 17609 2813 2814 RXA02598 GR00742 2576 3166
2815 2816 RXA02600 GR00742 5027 3630 2817 2818 RXA02601 GR00742
5258 7246 2819 2820 RXA02602 GR00742 7239 7742 2821 2822 RXA02604
GR00742 8800 10875 2823 2824 RXA02609 GR00742 16197 16445 2825 2826
RXA02617 GR00745 1404 1910 2827 2828 RXA02619 GR00746 204 1103 2829
2830 RXA02620 GR00746 1192 1845 2831 2832 RXA02639 GR00749 511 1344
2833 2834 RXA02647 GR00751 4155 4616 2835 2836 RXA02649 GR00752
1284 283 2837 2838 RXA02652 GR00752 2973 3551 2839 2840 RXA02655
GR00752 9313 8330 2841 2842 RXA02662 GR00753 1461 1724 2843 2844
RXA02665 GR00753 6497 6018 2845 2846 RXA02670 GR00753 10199 10780
2847 2848 RXA02672 GR00753 12303 13400 2849 2850 RXA02678 GR00754
3858 4775 2851 2852 RXA02683 GR00754 7742 7065 2853 2854 RXA02685
GR00754 10058 9402 2855 2856 RXA02688 GR00754 12256 12924 2857 2858
RXA02689 GR00754 13405 13064 2859 2860 RXA02690 GR00754 14502 13405
2861 2862 RXA02700 GR00757 3507 4742 2863 2864 RXA02701 GR00757
4838 6145 2865 2866 RXA02712 GR00758 13067 12273 2867 2868 RXA02714
GR00758 14754 14326 2869 2870 RXA02715 GR00758 15847 15458 2871
2872 RXA02721 GR00759 1373 636 2873 2874 RXA02725 GR00760 1478 867
2875 2876 RXA02727 GR00760 6287 5376 2877 2878 RXA02735 GR00763 777
73 2879 2880 RXA02736 GR00763 1753 797 2881 2882 RXA02751 GR00764
6393 5920 2883 2884 RXA02756 GR00766 3851 2961 2885 2886 RXA02757
GR00766 4475 3930 2887 2888 RXA02765 GR00769 3552 2794 2889 2890
RXA02766 GR00770 986 594 2891 2892 RXA02774 GR00773 3 473 2893 2894
RXA02775 GR00773 744 968 2895 2896 RXA02776 GR00773 1713 1372 2897
2898 RXA02777 GR00773 4626 5732 2899 2900 RXA02778 GR00773 10095
10319 2901 2902 RXA02779 GR00773 10617 10895 2903 2904 RXA02780
GR00773 10954 11280 2905 2906 RXA02783 GR00775 845 1393 2907 2908
RXA02784 GR00775 1751 1936 2909 2910 RXA02786 GR00777 2 808 2911
2912 RXA02789 GR00777 5237 5782 2913 2914 RXA02793 GR00777 9385
8684 2915 2916 RXA02796 GR00778 1648 1100 2917 2918 RXA02798
GR00778 2842 4266 2919 2920 RXA02799 GR00780 182 454 2921 2922
RXA02815 GR00796 3 554 2923 2924 RXA02823 GR00804 275 6 2925 2926
RXA02827 GR00812 428 6 2927 2928 RXA02842 GR00841 356 15 2929 2930
RXA02845 GR00844 2 616 2931 2932 RXA02848 GR00848 113 511
[0172]
Sequence CWU 0 SQTB SEQUENCE LISTING The patent application
contains a lengthy "Sequence Listing" section. A copy of the
"Sequence Listing" is available in electronic form from the USPTO
web site
(http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20070099213A1).
An electronic copy of the "Sequence Listing" will also be available
from the USPTO upon request and payment of the fee set forth in 37
CFR 1.19(b)(3).
0 SQTB SEQUENCE LISTING The patent application contains a lengthy
"Sequence Listing" section. A copy of the "Sequence Listing" is
available in electronic form from the USPTO web site
(http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20070099213A1).
An electronic copy of the "Sequence Listing" will also be available
from the USPTO upon request and payment of the fee set forth in 37
CFR 1.19(b)(3).
* * * * *
References