U.S. patent application number 11/194913 was filed with the patent office on 2007-04-05 for notch mutations leading to increased receptor signaling. This patent application is currently assigned to The Brigham and Women's Hospital, Inc.. Invention is credited to Jon C. Aster, Stephen C. Blacklow, Adolfo A. Ferrando, A. Thomas Look, Andrew P. Weng.
Application Number | 20070077245 11/194913 |
Document ID | / |
Family ID | 35787931 |
Filed Date | 2007-04-05 |
United States Patent Application | 20070077245 |
Kind Code | A1 |
Aster; Jon C. ; et al. | April 5, 2007 |
The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increased receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.
Inventors: | Aster; Jon C.; (Lexington, MA) ; Blacklow; Stephen C.; (Cambridge, MA) ; Look; A. Thomas; (North Reading, MA) ; Ferrando; Adolfo A.; (New York, NY) ; Weng; Andrew P.; (Vancouver, CA) |
Correspondence Address: |
LAW OFFICE OF MICHAEL A. SANZO, LLC 15400 CALHOUN DR. SUITE 125 ROCKVILLE MD 20855 US |
Assignee: | The Brigham and Women's Hospital,
Inc. Boston MA Dana-Farber Cancer Institute, Inc. Boston MA |
Family ID: | 35787931 |
Appl. No.: | 11/194913 |
Filed: | August 2, 2005 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
60598546 | Aug 4, 2004 | |||
60672053 | Apr 18, 2005 | |||
Current U.S. Class: | 424/144.1 ; 435/320.1; 435/325; 435/69.1; 435/7.23; 530/350; 530/388.22; 536/23.5 |
Current CPC Class: | G01N 33/57496 20130101; G01N 2333/70567 20130101; C07K 14/705 20130101; A61P 35/02 20180101; A61P 35/00 20180101; A61P 43/00 20180101; G01N 33/57484 20130101 |
Class at Publication: | 424/144.1 ; 530/350; 435/069.1; 435/320.1; 435/325; 536/023.5; 530/388.22; 435/007.23 |
International Class: | G01N 33/574 20060101 G01N033/574; C07H 21/04 20060101 C07H021/04; C12P 21/06 20060101 C12P021/06; A61K 39/395 20060101 A61K039/395; C07K 14/705 20060101 C07K014/705 |
Sequence CWU 1
1
164 1 2556 PRT Homo sapiens 1 Met Pro Pro Leu Leu Ala Pro Leu Leu
Cys Leu Ala Leu Leu Pro Ala 1 5 10 15 Leu Ala Ala Arg Gly Pro Arg
Cys Ser Gln Pro Gly Glu Thr Cys Leu 20 25 30 Asn Gly Gly Lys Cys
Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 35 40 45 Gly Gly Ala
Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 50 55 60 Ser
Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 65 70
75 80 Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly
Pro 85 90 95 Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn
Pro Cys Arg 100 105 110 Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr
Glu Tyr Lys Cys Arg 115 120 125 Cys Pro Pro Gly Trp Ser Gly Lys Ser
Cys Gln Gln Ala Asp Pro Cys 130 135 140 Ala Ser Asn Pro Cys Ala Asn
Gly Gly Gln Cys Leu Pro Phe Glu Ala 145 150 155 160 Ser Tyr Ile Cys
His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 165 170 175 Gln Asp
Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly 180 185 190
Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 195
200 205 Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser
Pro 210 215 220 Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly
Asp Val Thr 225 230 235 240 His Glu Cys Ala Cys Leu Pro Gly Phe Thr
Gly Gln Asn Cys Glu Glu 245 250 255 Asn Ile Asp Asp Cys Pro Gly Asn
Asn Cys Lys Asn Gly Gly Ala Cys 260 265 270 Val Asp Gly Val Asn Thr
Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 275 280 285 Gly Gln Tyr Cys
Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 290 295 300 Ala Cys
Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 305 310 315
320 Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile
325 330 335 Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys
His Asp 340 345 350 Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly
Arg Thr Gly Leu 355 360 365 Leu Cys His Leu Asn Asp Ala Cys Ile Ser
Asn Pro Cys Asn Glu Gly 370 375 380 Ser Asn Cys Asp Thr Asn Pro Val
Asn Gly Lys Ala Ile Cys Thr Cys 385 390 395 400 Pro Ser Gly Tyr Thr
Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 405 410 415 Ser Leu Gly
Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 420 425 430 Leu
Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 435 440
445 Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp
450 455 460 Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys
Met Pro 465 470 475 480 Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr
Asp Glu Cys Ala Ser 485 490 495 Ser Pro Cys Leu His Asn Gly Arg Cys
Leu Asp Lys Ile Asn Glu Phe 500 505 510 Gln Cys Glu Cys Pro Thr Gly
Phe Thr Gly His Leu Cys Gln Tyr Asp 515 520 525 Val Asp Glu Cys Ala
Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 530 535 540 Asp Gly Pro
Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 545 550 555 560
Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 565
570 575 Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys
Arg 580 585 590 Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn
Glu Cys Ser 595 600 605 Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln
Asp Arg Asp Asn Ala 610 615 620 Tyr Leu Cys Phe Cys Leu Lys Gly Thr
Thr Gly Pro Asn Cys Glu Ile 625 630 635 640 Asn Leu Asp Asp Cys Ala
Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 645 650 655 Asp Lys Ile Asp
Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 660 665 670 Ser Met
Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 675 680 685
Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 690
695 700 Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu
Cys 705 710 715 720 Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp
Ser Leu Asn Gly 725 730 735 Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser
Gly Thr Asn Cys Asp Ile 740 745 750 Asn Asn Asn Glu Cys Glu Ser Asn
Pro Cys Val Asn Gly Gly Thr Cys 755 760 765 Lys Asp Met Thr Ser Gly
Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 770 775 780 Gly Pro Asn Cys
Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 785 790 795 800 Leu
Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 805 810
815 Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro
820 825 830 Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln
Ser Glu 835 840 845 Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly
Trp Gln Ala Gly 850 855 860 Gln Thr Cys Glu Val Asp Ile Asn Glu Cys
Val Leu Ser Pro Cys Arg 865 870 875 880 His Gly Ala Ser Cys Gln Asn
Thr His Gly Gly Tyr Arg Cys His Cys 885 890 895 Gln Ala Gly Tyr Ser
Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys 900 905 910 Arg Pro Asn
Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn 915 920 925 Thr
Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu 930 935
940 Glu Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn
945 950 955 960 Cys Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro
Ala Gly Phe 965 970 975 Ser Gly Ile His Cys Glu Asn Asn Thr Pro Asp
Cys Thr Glu Ser Ser 980 985 990 Cys Phe Asn Gly Gly Thr Cys Val Asp
Gly Ile Asn Ser Phe Thr Cys 995 1000 1005 Leu Cys Pro Pro Gly Phe
Thr Gly Ser Tyr Cys Gln His Asp Val 1010 1015 1020 Asn Glu Cys Asp
Ser Gln Pro Cys Leu His Gly Gly Thr Cys Gln 1025 1030 1035 Asp Gly
Cys Gly Ser Tyr Arg Cys Thr Cys Pro Gln Gly Tyr Thr 1040 1045 1050
Gly Pro Asn Cys Gln Asn Leu Val His Trp Cys Asp Ser Ser Pro 1055
1060 1065 Cys Lys Asn Gly Gly Lys Cys Trp Gln Thr His Thr Gln Tyr
Arg 1070 1075 1080 Cys Glu Cys Pro Ser Gly Trp Thr Gly Leu Tyr Cys
Asp Val Pro 1085 1090 1095 Ser Val Ser Cys Glu Val Ala Ala Gln Arg
Gln Gly Val Asp Val 1100 1105 1110 Ala Arg Leu Cys Gln His Gly Gly
Leu Cys Val Asp Ala Gly Asn 1115 1120 1125 Thr His His Cys Arg Cys
Gln Ala Gly Tyr Thr Gly Ser Tyr Cys 1130 1135 1140 Glu Asp Leu Val
Asp Glu Cys Ser Pro Ser Pro Cys Gln Asn Gly 1145 1150 1155 Ala Thr
Cys Thr Asp Tyr Leu Gly Gly Tyr Ser Cys Lys Cys Val 1160 1165 1170
Ala Gly Tyr His Gly Val Asn Cys Ser Glu Glu Ile Asp Glu Cys 1175
1180 1185 Leu Ser His Pro Cys Gln Asn Gly Gly Thr Cys Leu Asp Leu
Pro 1190 1195 1200 Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly Thr Gln
Gly Val His 1205 1210 1215 Cys Glu Ile Asn Val Asp Asp Cys Asn Pro
Pro Val Asp Pro Val 1220 1225 1230 Ser Arg Ser Pro Lys Cys Phe Asn
Asn Gly Thr Cys Val Asp Gln 1235 1240 1245 Val Gly Gly Tyr Ser Cys
Thr Cys Pro Pro Gly Phe Val Gly Glu 1250 1255 1260 Arg Cys Glu Gly
Asp Val Asn Glu Cys Leu Ser Asn Pro Cys Asp 1265 1270 1275 Ala Arg
Gly Thr Gln Asn Cys Val Gln Arg Val Asn Asp Phe His 1280 1285 1290
Cys Glu Cys Arg Ala Gly His Thr Gly Arg Arg Cys Glu Ser Val 1295
1300 1305 Ile Asn Gly Cys Lys Gly Lys Pro Cys Lys Asn Gly Gly Thr
Cys 1310 1315 1320 Ala Val Ala Ser Asn Thr Ala Arg Gly Phe Ile Cys
Lys Cys Pro 1325 1330 1335 Ala Gly Phe Glu Gly Ala Thr Cys Glu Asn
Asp Ala Arg Thr Cys 1340 1345 1350 Gly Ser Leu Arg Cys Leu Asn Gly
Gly Thr Cys Ile Ser Gly Pro 1355 1360 1365 Arg Ser Pro Thr Cys Leu
Cys Leu Gly Pro Phe Thr Gly Pro Glu 1370 1375 1380 Cys Gln Phe Pro
Ala Ser Ser Pro Cys Leu Gly Gly Asn Pro Cys 1385 1390 1395 Tyr Asn
Gln Gly Thr Cys Glu Pro Thr Ser Glu Ser Pro Phe Tyr 1400 1405 1410
Arg Cys Leu Cys Pro Ala Lys Phe Asn Gly Leu Leu Cys His Ile 1415
1420 1425 Leu Asp Tyr Ser Phe Gly Gly Gly Ala Gly Arg Asp Ile Pro
Pro 1430 1435 1440 Pro Leu Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys
Gln Glu Asp 1445 1450 1455 Ala Gly Asn Lys Val Cys Ser Leu Gln Cys
Asn Asn His Ala Cys 1460 1465 1470 Gly Trp Asp Gly Gly Asp Cys Ser
Leu Asn Phe Asn Asp Pro Trp 1475 1480 1485 Lys Asn Cys Thr Gln Ser
Leu Gln Cys Trp Lys Tyr Phe Ser Asp 1490 1495 1500 Gly His Cys Asp
Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp 1505 1510 1515 Gly Phe
Asp Cys Gln Arg Ala Glu Gly Gln Cys Asn Pro Leu Tyr 1520 1525 1530
Asp Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln 1535
1540 1545 Gly Cys Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys
Ala 1550 1555 1560 Glu His Val Pro Glu Arg Leu Ala Ala Gly Thr Leu
Val Val Val 1565 1570 1575 Val Leu Met Pro Pro Glu Gln Leu Arg Asn
Ser Ser Phe His Phe 1580 1585 1590 Leu Arg Glu Leu Ser Arg Val Leu
His Thr Asn Val Val Phe Lys 1595 1600 1605 Arg Asp Ala His Gly Gln
Gln Met Ile Phe Pro Tyr Tyr Gly Arg 1610 1615 1620 Glu Glu Glu Leu
Arg Lys His Pro Ile Lys Arg Ala Ala Glu Gly 1625 1630 1635 Trp Ala
Ala Pro Asp Ala Leu Leu Gly Gln Val Lys Ala Ser Leu 1640 1645 1650
Leu Pro Gly Gly Ser Glu Gly Gly Arg Arg Arg Arg Glu Leu Asp 1655
1660 1665 Pro Met Asp Val Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp
Asn 1670 1675 1680 Arg Gln Cys Val Gln Ala Ser Ser Gln Cys Phe Gln
Ser Ala Thr 1685 1690 1695 Asp Val Ala Ala Phe Leu Gly Ala Leu Ala
Ser Leu Gly Ser Leu 1700 1705 1710 Asn Ile Pro Tyr Lys Ile Glu Ala
Val Gln Ser Glu Thr Val Glu 1715 1720 1725 Pro Pro Pro Pro Ala Gln
Leu His Phe Met Tyr Val Ala Ala Ala 1730 1735 1740 Ala Phe Val Leu
Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 1745 1750 1755 Arg Lys
Arg Arg Arg Gln His Gly Gln Leu Trp Phe Pro Glu Gly 1760 1765 1770
Phe Lys Val Ser Glu Ala Ser Lys Lys Lys Arg Arg Glu Pro Leu 1775
1780 1785 Gly Glu Asp Ser Val Gly Leu Lys Pro Leu Lys Asn Ala Ser
Asp 1790 1795 1800 Gly Ala Leu Met Asp Asp Asn Gln Asn Glu Trp Gly
Asp Glu Asp 1805 1810 1815 Leu Glu Thr Lys Lys Phe Arg Phe Glu Glu
Pro Val Val Leu Pro 1820 1825 1830 Asp Leu Asp Asp Gln Thr Asp His
Arg Gln Trp Thr Gln Gln His 1835 1840 1845 Leu Asp Ala Ala Asp Leu
Arg Met Ser Ala Met Ala Pro Thr Pro 1850 1855 1860 Pro Gln Gly Glu
Val Asp Ala Asp Cys Met Asp Val Asn Val Arg 1865 1870 1875 Gly Pro
Asp Gly Phe Thr Pro Leu Met Ile Ala Ser Cys Ser Gly 1880 1885 1890
Gly Gly Leu Glu Thr Gly Asn Ser Glu Glu Glu Glu Asp Ala Pro 1895
1900 1905 Ala Val Ile Ser Asp Phe Ile Tyr Gln Gly Ala Ser Leu His
Asn 1910 1915 1920 Gln Thr Asp Arg Thr Gly Glu Thr Ala Leu His Leu
Ala Ala Arg 1925 1930 1935 Tyr Ser Arg Ser Asp Ala Ala Lys Arg Leu
Leu Glu Ala Ser Ala 1940 1945 1950 Asp Ala Asn Ile Gln Asp Asn Met
Gly Arg Thr Pro Leu His Ala 1955 1960 1965 Ala Val Ser Ala Asp Ala
Gln Gly Val Phe Gln Ile Leu Ile Arg 1970 1975 1980 Asn Arg Ala Thr
Asp Leu Asp Ala Arg Met His Asp Gly Thr Thr 1985 1990 1995 Pro Leu
Ile Leu Ala Ala Arg Leu Ala Val Glu Gly Met Leu Glu 2000 2005 2010
Asp Leu Ile Asn Ser His Ala Asp Val Asn Ala Val Asp Asp Leu 2015
2020 2025 Gly Lys Ser Ala Leu His Trp Ala Ala Ala Val Asn Asn Val
Asp 2030 2035 2040 Ala Ala Val Val Leu Leu Lys Asn Gly Ala Asn Lys
Asp Met Gln 2045 2050 2055 Asn Asn Arg Glu Glu Thr Pro Leu Phe Leu
Ala Ala Arg Glu Gly 2060 2065 2070 Ser Tyr Glu Thr Ala Lys Val Leu
Leu Asp His Phe Ala Asn Arg 2075 2080 2085 Asp Ile Thr Asp His Met
Asp Arg Leu Pro Arg Asp Ile Ala Gln 2090 2095 2100 Glu Arg Met His
His Asp Ile Val Arg Leu Leu Asp Glu Tyr Asn 2105 2110 2115 Leu Val
Arg Ser Pro Gln Leu His Gly Ala Pro Leu Gly Gly Thr 2120 2125 2130
Pro Thr Leu Ser Pro Pro Leu Cys Ser Pro Asn Gly Tyr Leu Gly 2135
2140 2145 Ser Leu Lys Pro Gly Val Gln Gly Lys Lys Val Arg Lys Pro
Ser 2150 2155 2160 Ser Lys Gly Leu Ala Cys Gly Ser Lys Glu Ala Lys
Asp Leu Lys 2165 2170 2175 Ala Arg Arg Lys Lys Ser Gln Asp Gly Lys
Gly Cys Leu Leu Asp 2180 2185 2190 Ser Ser Gly Met Leu Ser Pro Val
Asp Ser Leu Glu Ser Pro His 2195 2200 2205 Gly Tyr Leu Ser Asp Val
Ala Ser Pro Pro Leu Leu Pro Ser Pro 2210 2215 2220 Phe Gln Gln Ser
Pro Ser Val Pro Leu Asn His Leu Pro Gly Met 2225 2230 2235 Pro Asp
Thr His Leu Gly Ile Gly His Leu Asn Val Ala Ala Lys 2240 2245 2250
Pro Glu Met Ala Ala Leu Gly Gly Gly Gly Arg Leu Ala Phe Glu 2255
2260 2265 Thr Gly Pro Pro Arg Leu Ser His Leu Pro Val Ala Ser Gly
Thr 2270 2275 2280 Ser Thr Val Leu Gly Ser Ser Ser Gly Gly Ala Leu
Asn Phe Thr 2285 2290 2295 Val Gly Gly Ser Thr Ser Leu Asn Gly Gln
Cys Glu Trp Leu Ser 2300 2305 2310 Arg Leu Gln Ser Gly Met Val Pro
Asn Gln Tyr Asn Pro Leu Arg 2315 2320 2325 Gly Ser Val Ala Pro Gly
Pro Leu Ser Thr Gln Ala Pro Ser Leu 2330 2335 2340 Gln His Gly Met
Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 2345 2350 2355 Ala Leu
Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg 2360 2365 2370
Leu Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro 2375
2380 2385 Gln Asn Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn
Ile 2390 2395 2400 Gln Gln Gln Gln Ser Leu Gln Pro Pro Pro Pro Pro
Pro Gln Pro 2405
2410 2415 His Leu Gly Val Ser Ser Ala Ala Ser Gly His Leu Gly Arg
Ser 2420 2425 2430 Phe Leu Ser Gly Glu Pro Ser Gln Ala Asp Val Gln
Pro Leu Gly 2435 2440 2445 Pro Ser Ser Leu Ala Val His Thr Ile Leu
Pro Gln Glu Ser Pro 2450 2455 2460 Ala Leu Pro Thr Ser Leu Pro Ser
Ser Leu Val Pro Pro Val Thr 2465 2470 2475 Ala Ala Gln Phe Leu Thr
Pro Pro Ser Gln His Ser Tyr Ser Ser 2480 2485 2490 Pro Val Asp Asn
Thr Pro Ser His Gln Leu Gln Val Pro Glu His 2495 2500 2505 Pro Phe
Leu Thr Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser Ser 2510 2515 2520
Ser Ser Pro His Ser Asn Val Ser Asp Trp Ser Glu Gly Val Ser 2525
2530 2535 Ser Pro Pro Thr Ser Met Gln Ser Gln Ile Ala Arg Ile Pro
Glu 2540 2545 2550 Ala Phe Lys 2555 2 2471 PRT Homo sapiens 2 Met
Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 1 5 10
15 Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr
20 25 30 Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn
Gly Thr 35 40 45 Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu
Tyr Cys Gln His 50 55 60 Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln
Asn Gly Gly Thr Cys Val 65 70 75 80 Ala Gln Ala Met Leu Gly Lys Ala
Thr Cys Arg Cys Ala Ser Gly Phe 85 90 95 Thr Gly Glu Asp Cys Gln
Tyr Ser Thr Ser His Pro Cys Phe Val Ser 100 105 110 Arg Pro Cys Leu
Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 115 120 125 Tyr Glu
Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 130 135 140
Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 145
150 155 160 Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe
Thr Gly 165 170 175 Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile
Pro Gly His Cys 180 185 190 Gln His Gly Gly Thr Cys Leu Asn Leu Pro
Gly Ser Tyr Gln Cys Gln 195 200 205 Cys Pro Gln Gly Phe Thr Gly Gln
Tyr Cys Asp Ser Leu Tyr Val Pro 210 215 220 Cys Ala Pro Ser Pro Cys
Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 225 230 235 240 Asp Phe Thr
Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 245 250 255 Cys
Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 260 265
270 Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro
275 280 285 Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys
Leu Leu 290 295 300 Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala
Asn Arg Asn Gly 305 310 315 320 Gly Tyr Gly Cys Val Cys Val Asn Gly
Trp Ser Gly Asp Asp Cys Ser 325 330 335 Glu Asn Ile Asp Asp Cys Ala
Phe Ala Ser Cys Thr Pro Gly Ser Thr 340 345 350 Cys Ile Asp Arg Val
Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 355 360 365 Ala Gly Leu
Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 370 375 380 His
Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 385 390
395 400 Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp
Val 405 410 415 Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His
Ala Gly Lys 420 425 430 Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu
Cys Leu Lys Gly Tyr 435 440 445 Ala Gly Pro Arg Cys Glu Met Asp Ile
Asn Glu Cys His Ser Asp Pro 450 455 460 Cys Gln Asn Asp Ala Thr Cys
Leu Asp Lys Ile Gly Gly Phe Thr Cys 465 470 475 480 Leu Cys Met Pro
Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 485 490 495 Glu Cys
Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 500 505 510
Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 515
520 525 Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn
Gly 530 535 540 Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln
Cys Ala Thr 545 550 555 560 Gly Phe Thr Gly Val Leu Cys Glu Glu Asn
Ile Asp Asn Cys Asp Pro 565 570 575 Asp Pro Cys His His Gly Gln Cys
Gln Asp Gly Ile Asp Ser Tyr Thr 580 585 590 Cys Ile Cys Asn Pro Gly
Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 595 600 605 Asp Glu Cys Tyr
Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 610 615 620 Leu Val
Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 625 630 635
640 Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His
645 650 655 Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys
Ser Pro 660 665 670 Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp
Glu Cys Ala Ser 675 680 685 Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile
Asn Gly Val Asn Gly Phe 690 695 700 Arg Cys Ile Cys Pro Glu Gly Pro
His His Pro Ser Cys Tyr Ser Gln 705 710 715 720 Val Asn Glu Cys Leu
Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 725 730 735 Gly Leu Ser
Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 740 745 750 Asn
Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 755 760
765 Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys
770 775 780 Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu
Cys Ala 785 790 795 800 Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe
Asp Asp Ile Ser Gly 805 810 815 Tyr Thr Cys His Cys Val Leu Pro Tyr
Thr Gly Lys Asn Cys Gln Thr 820 825 830 Val Leu Ala Pro Cys Ser Pro
Asn Pro Cys Glu Asn Ala Ala Val Cys 835 840 845 Lys Glu Ser Pro Asn
Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 850 855 860 Trp Gln Gly
Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 865 870 875 880
Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 885
890 895 Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp
Ile 900 905 910 Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser
Cys Met Asp 915 920 925 Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro
Gly Phe Thr Gly Asp 930 935 940 Lys Cys Gln Thr Asp Met Asn Glu Cys
Leu Ser Glu Pro Cys Lys Asn 945 950 955 960 Gly Gly Thr Cys Ser Asp
Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 965 970 975 Ala Gly Phe Asp
Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 980 985 990 Glu Ser
Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser 995 1000
1005 Phe Ser Cys Leu Cys Pro Val Gly Phe Thr Gly Ser Phe Cys Leu
1010 1015 1020 His Glu Ile Asn Glu Cys Ser Ser His Pro Cys Leu Asn
Glu Gly 1025 1030 1035 Thr Cys Val Asp Gly Leu Gly Thr Tyr Arg Cys
Ser Cys Pro Leu 1040 1045 1050 Gly Tyr Thr Gly Lys Asn Cys Gln Thr
Leu Val Asn Leu Cys Ser 1055 1060 1065 Arg Ser Pro Cys Lys Asn Lys
Gly Thr Cys Val Gln Lys Lys Ala 1070 1075 1080 Glu Ser Gln Cys Leu
Cys Pro Ser Gly Trp Ala Gly Ala Tyr Cys 1085 1090 1095 Asp Val Pro
Asn Val Ser Cys Asp Ile Ala Ala Ser Arg Arg Gly 1100 1105 1110 Val
Leu Val Glu His Leu Cys Gln His Ser Gly Val Cys Ile Asn 1115 1120
1125 Ala Gly Asn Thr His Tyr Cys Gln Cys Pro Leu Gly Tyr Thr Gly
1130 1135 1140 Ser Tyr Cys Glu Glu Gln Leu Asp Glu Cys Ala Ser Asn
Pro Cys 1145 1150 1155 Gln His Gly Ala Thr Cys Ser Asp Phe Ile Gly
Gly Tyr Arg Cys 1160 1165 1170 Glu Cys Val Pro Gly Tyr Gln Gly Val
Asn Cys Glu Tyr Glu Val 1175 1180 1185 Asp Glu Cys Gln Asn Gln Pro
Cys Gln Asn Gly Gly Thr Cys Ile 1190 1195 1200 Asp Leu Val Asn His
Phe Lys Cys Ser Cys Pro Pro Gly Thr Arg 1205 1210 1215 Gly Leu Leu
Cys Glu Glu Asn Ile Asp Asp Cys Ala Arg Gly Pro 1220 1225 1230 His
Cys Leu Asn Gly Gly Gln Cys Met Asp Arg Ile Gly Gly Tyr 1235 1240
1245 Ser Cys Arg Cys Leu Pro Gly Phe Ala Gly Glu Arg Cys Glu Gly
1250 1255 1260 Asp Ile Asn Glu Cys Leu Ser Asn Pro Cys Ser Ser Glu
Gly Ser 1265 1270 1275 Leu Asp Cys Ile Gln Leu Thr Asn Asp Tyr Leu
Cys Val Cys Arg 1280 1285 1290 Ser Ala Phe Thr Gly Arg His Cys Glu
Thr Phe Val Asp Val Cys 1295 1300 1305 Pro Gln Met Pro Cys Leu Asn
Gly Gly Thr Cys Ala Val Ala Ser 1310 1315 1320 Asn Met Pro Asp Gly
Phe Ile Cys Arg Cys Pro Pro Gly Phe Ser 1325 1330 1335 Gly Ala Arg
Cys Gln Ser Ser Cys Gly Gln Val Lys Cys Arg Lys 1340 1345 1350 Gly
Glu Gln Cys Val His Thr Ala Ser Gly Pro Arg Cys Phe Cys 1355 1360
1365 Pro Ser Pro Arg Asp Cys Glu Ser Gly Cys Ala Ser Ser Pro Cys
1370 1375 1380 Gln His Gly Gly Ser Cys His Pro Gln Arg Gln Pro Pro
Tyr Tyr 1385 1390 1395 Ser Cys Gln Cys Ala Pro Pro Phe Ser Gly Ser
Arg Cys Glu Leu 1400 1405 1410 Tyr Thr Ala Pro Pro Ser Thr Pro Pro
Ala Thr Cys Leu Ser Gln 1415 1420 1425 Tyr Cys Ala Asp Lys Ala Arg
Asp Gly Val Cys Asp Glu Ala Cys 1430 1435 1440 Asn Ser His Ala Cys
Gln Trp Asp Gly Gly Asp Cys Ser Leu Thr 1445 1450 1455 Met Glu Asn
Pro Trp Ala Asn Cys Ser Ser Pro Leu Pro Cys Trp 1460 1465 1470 Asp
Tyr Ile Asn Asn Gln Cys Asp Glu Leu Cys Asn Thr Val Glu 1475 1480
1485 Cys Leu Phe Asp Asn Phe Glu Cys Gln Gly Asn Ser Lys Thr Cys
1490 1495 1500 Lys Tyr Asp Lys Tyr Cys Ala Asp His Phe Lys Asp Asn
His Cys 1505 1510 1515 Asp Gln Gly Cys Asn Ser Glu Glu Cys Gly Trp
Asp Gly Leu Asp 1520 1525 1530 Cys Ala Ala Asp Gln Pro Glu Asn Leu
Ala Glu Gly Thr Leu Val 1535 1540 1545 Ile Val Val Leu Met Pro Pro
Glu Gln Leu Leu Gln Asp Ala Arg 1550 1555 1560 Ser Phe Leu Arg Ala
Leu Gly Thr Leu Leu His Thr Asn Leu Arg 1565 1570 1575 Ile Lys Arg
Asp Ser Gln Gly Glu Leu Met Val Tyr Pro Tyr Tyr 1580 1585 1590 Gly
Glu Lys Ser Ala Ala Met Lys Lys Gln Arg Met Thr Arg Arg 1595 1600
1605 Ser Leu Pro Gly Glu Gln Glu Gln Glu Val Ala Gly Ser Lys Val
1610 1615 1620 Phe Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Asp Ser
Asp His 1625 1630 1635 Cys Phe Lys Asn Thr Asp Ala Ala Ala Ala Leu
Leu Ala Ser His 1640 1645 1650 Ala Ile Gln Gly Thr Leu Ser Tyr Pro
Leu Val Ser Val Val Ser 1655 1660 1665 Glu Ser Leu Thr Pro Glu Arg
Thr Gln Leu Leu Tyr Leu Leu Ala 1670 1675 1680 Val Ala Val Val Ile
Ile Leu Phe Ile Ile Leu Leu Gly Val Ile 1685 1690 1695 Met Ala Lys
Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro Glu 1700 1705 1710 Gly
Phe Thr Leu Arg Arg Asp Ala Ser Asn His Lys Arg Arg Glu 1715 1720
1725 Pro Val Gly Gln Asp Ala Val Gly Leu Lys Asn Leu Ser Val Gln
1730 1735 1740 Val Ser Glu Ala Asn Leu Ile Gly Thr Gly Thr Ser Glu
His Trp 1745 1750 1755 Val Asp Asp Glu Gly Pro Gln Pro Lys Lys Val
Lys Ala Glu Asp 1760 1765 1770 Glu Ala Leu Leu Ser Glu Glu Asp Asp
Pro Ile Asp Arg Arg Pro 1775 1780 1785 Trp Thr Gln Gln His Leu Glu
Ala Ala Asp Ile Arg Arg Thr Pro 1790 1795 1800 Ser Leu Ala Leu Thr
Pro Pro Gln Ala Glu Gln Glu Val Asp Val 1805 1810 1815 Leu Asp Val
Asn Val Arg Gly Pro Asp Gly Cys Thr Pro Leu Met 1820 1825 1830 Leu
Ala Ser Leu Arg Gly Gly Ser Ser Asp Leu Ser Asp Glu Asp 1835 1840
1845 Glu Asp Ala Glu Asp Ser Ser Ala Asn Ile Ile Thr Asp Leu Val
1850 1855 1860 Tyr Gln Gly Ala Ser Leu Gln Ala Gln Thr Asp Arg Thr
Gly Glu 1865 1870 1875 Met Ala Leu His Leu Ala Ala Arg Tyr Ser Arg
Ala Asp Ala Ala 1880 1885 1890 Lys Arg Leu Leu Asp Ala Gly Ala Asp
Ala Asn Ala Gln Asp Asn 1895 1900 1905 Met Gly Arg Cys Pro Leu His
Ala Ala Val Ala Ala Asp Ala Gln 1910 1915 1920 Gly Val Phe Gln Ile
Leu Ile Arg Asn Arg Val Thr Asp Leu Asp 1925 1930 1935 Ala Arg Met
Asn Asp Gly Thr Thr Pro Leu Ile Leu Ala Ala Arg 1940 1945 1950 Leu
Ala Val Glu Gly Met Val Ala Glu Leu Ile Asn Cys Gln Ala 1955 1960
1965 Asp Val Asn Ala Val Asp Asp His Gly Lys Ser Ala Leu His Trp
1970 1975 1980 Ala Ala Ala Val Asn Asn Val Glu Ala Thr Leu Leu Leu
Leu Lys 1985 1990 1995 Asn Gly Ala Asn Arg Asp Met Gln Asp Asn Lys
Glu Glu Thr Pro 2000 2005 2010 Leu Phe Leu Ala Ala Arg Glu Gly Ser
Tyr Glu Ala Ala Lys Ile 2015 2020 2025 Leu Leu Asp His Phe Ala Asn
Arg Asp Ile Thr Asp His Met Asp 2030 2035 2040 Arg Leu Pro Arg Asp
Val Ala Arg Asp Arg Met His His Asp Ile 2045 2050 2055 Val Arg Leu
Leu Asp Glu Tyr Asn Val Thr Pro Ser Pro Pro Gly 2060 2065 2070 Thr
Val Leu Thr Ser Ala Leu Ser Pro Val Ile Cys Gly Pro Asn 2075 2080
2085 Arg Ser Phe Leu Ser Leu Lys His Thr Pro Met Gly Lys Lys Ser
2090 2095 2100 Arg Arg Pro Ser Ala Lys Ser Thr Met Pro Thr Ser Leu
Pro Asn 2105 2110 2115 Leu Ala Lys Glu Ala Lys Asp Ala Lys Gly Ser
Arg Arg Lys Lys 2120 2125 2130 Ser Leu Ser Glu Lys Val Gln Leu Ser
Glu Ser Ser Val Thr Leu 2135 2140 2145 Ser Pro Val Asp Ser Leu Glu
Ser Pro His Thr Tyr Val Ser Asp 2150 2155 2160 Thr Thr Ser Ser Pro
Met Ile Thr Ser Pro Gly Ile Leu Gln Ala 2165 2170 2175 Ser Pro Asn
Pro Met Leu Ala Thr Ala Ala Pro Pro Ala Pro Val 2180 2185 2190 His
Ala Gln His Ala Leu Ser Phe Ser Asn Leu His Glu Met Gln 2195 2200
2205 Pro Leu Ala His Gly Ala Ser Thr Val Leu Pro Ser Val Ser Gln
2210 2215 2220 Leu Leu Ser His His His Ile Val Ser Pro Gly Ser Gly
Ser Ala 2225 2230 2235 Gly Ser Leu Ser Arg Leu His Pro Val Pro Val
Pro Ala Asp Trp 2240 2245 2250 Met Asn Arg Met Glu Val Asn Glu Thr
Gln Tyr Asn Glu Met Phe 2255 2260 2265 Gly Met Val Leu Ala Pro Ala
Glu Gly Thr His
Pro Gly Ile Ala 2270 2275 2280 Pro Gln Ser Arg Pro Pro Glu Gly Lys
His Ile Thr Thr Pro Arg 2285 2290 2295 Glu Pro Leu Pro Pro Ile Val
Thr Phe Gln Leu Ile Pro Lys Gly 2300 2305 2310 Ser Ile Ala Gln Pro
Ala Gly Ala Pro Gln Pro Gln Ser Thr Cys 2315 2320 2325 Pro Pro Ala
Val Ala Gly Pro Leu Pro Thr Met Tyr Gln Ile Pro 2330 2335 2340 Glu
Met Ala Arg Leu Pro Ser Val Ala Phe Pro Thr Ala Met Met 2345 2350
2355 Pro Gln Gln Asp Gly Gln Val Ala Gln Thr Ile Leu Pro Ala Tyr
2360 2365 2370 His Pro Phe Pro Ala Ser Val Gly Lys Tyr Pro Thr Pro
Pro Ser 2375 2380 2385 Gln His Ser Tyr Ala Ser Ser Asn Ala Ala Glu
Arg Thr Pro Ser 2390 2395 2400 His Ser Gly His Leu Gln Gly Glu His
Pro Tyr Leu Thr Pro Ser 2405 2410 2415 Pro Glu Ser Pro Asp Gln Trp
Ser Ser Ser Ser Pro His Ser Ala 2420 2425 2430 Ser Asp Trp Ser Asp
Val Thr Thr Ser Pro Thr Pro Gly Gly Ala 2435 2440 2445 Gly Gly Gly
Gln Arg Gly Pro Gly Thr His Met Ser Glu Pro Pro 2450 2455 2460 His
Asn Asn Met Gln Val Tyr Ala 2465 2470 3 2319 PRT Homo sapiens 3 Met
Gly Leu Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Leu Met Ala 1 5 10
15 Leu Pro Pro Pro Pro Pro Pro Met Arg Ala Leu Pro Leu Leu Leu Leu
20 25 30 Leu Ala Gly Leu Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly
Ser Pro 35 40 45 Cys Ala Asn Gly Gly Arg Cys Thr His Gln Gln Pro
Ser Leu Glu Ala 50 55 60 Ala Cys Leu Cys Leu Pro Gly Trp Val Gly
Glu Arg Cys Gln Leu Glu 65 70 75 80 Asp Pro Cys His Ser Gly Pro Cys
Ala Gly Arg Gly Val Cys Gln Ser 85 90 95 Ser Val Val Ala Gly Thr
Ala Arg Phe Ser Cys Arg Cys Leu Arg Gly 100 105 110 Phe Gln Gly Pro
Asp Cys Ser Gln Pro Asp Pro Cys Val Ser Arg Pro 115 120 125 Cys Val
His Gly Ala Pro Cys Ser Val Gly Pro Asp Gly Arg Phe Ala 130 135 140
Cys Ala Cys Pro Pro Gly Tyr Gln Gly Gln Ser Cys Gln Ser Asp Ile 145
150 155 160 Asp Glu Cys Arg Ser Gly Thr Thr Cys Arg His Gly Gly Thr
Cys Leu 165 170 175 Asn Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Leu
Gly Tyr Thr Gly 180 185 190 Leu Leu Cys Glu Asn Pro Val Val Pro Cys
Ala Pro Ser Pro Cys Arg 195 200 205 Asn Gly Gly Thr Cys Arg Gln Ser
Ser Asp Val Thr Tyr Asp Cys Ala 210 215 220 Cys Leu Pro Gly Phe Glu
Gly Gln Asn Cys Glu Val Asn Val Asp Asp 225 230 235 240 Cys Pro Gly
His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val 245 250 255 Asn
Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys 260 265
270 Thr Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn
275 280 285 Gly Gly Thr Cys Phe Asn Leu Leu Gly Gly His Ser Cys Val
Cys Val 290 295 300 Asn Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile
Asp Asp Cys Ala 305 310 315 320 Thr Ala Val Cys Phe His Gly Ala Thr
Cys His Asp Arg Val Ala Ser 325 330 335 Phe Tyr Cys Ala Cys Pro Met
Gly Lys Thr Gly Leu Leu Cys His Leu 340 345 350 Asp Asp Ala Cys Val
Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp 355 360 365 Thr Asn Pro
Val Ser Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe 370 375 380 Thr
Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala 385 390
395 400 Asn Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser
Phe 405 410 415 Leu Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys
Glu Thr Asp 420 425 430 Val Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn
Gln Ala Thr Cys Leu 435 440 445 Asp Arg Ile Gly Gln Phe Thr Cys Ile
Cys Met Ala Gly Phe Thr Gly 450 455 460 Thr Tyr Cys Glu Val Asp Ile
Asp Glu Cys Gln Ser Ser Pro Cys Val 465 470 475 480 Asn Gly Gly Val
Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys 485 490 495 Pro Ser
Gly Phe Ser Gly Ser Met Cys Gln Leu Asp Val Asp Glu Cys 500 505 510
Ala Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp 515
520 525 Gly Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys
Glu 530 535 540 Arg Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His
Gly Arg Cys 545 550 555 560 Val Asp Gly Ile Ala Ser Phe Ser Cys Ala
Cys Ala Pro Gly Tyr Thr 565 570 575 Gly Ile Arg Cys Glu Ser Gln Val
Asp Glu Cys Arg Ser Gln Pro Cys 580 585 590 Arg Tyr Gly Gly Lys Cys
Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg 595 600 605 Cys Pro Pro Gly
Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp 610 615 620 Cys Ala
Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn 625 630 635
640 Arg Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn
645 650 655 Val Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly
Gly Ser 660 665 670 Cys Val Asp Gly Glu Asn Gly Phe His Cys Leu Cys
Pro Pro Gly Ser 675 680 685 Leu Pro Pro Leu Cys Leu Pro Ala Asn His
Pro Cys Ala His Lys Pro 690 695 700 Cys Ser His Gly Val Cys His Asp
Ala Pro Gly Gly Phe Arg Cys Val 705 710 715 720 Cys Glu Pro Gly Trp
Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Pro 725 730 735 Asp Ala Cys
Glu Ser Gln Pro Cys Gln Ala Gly Gly Thr Cys Thr Ser 740 745 750 Asp
Gly Ile Gly Phe Arg Cys Thr Cys Ala Pro Gly Phe Gln Gly His 755 760
765 Gln Cys Glu Val Leu Ser Pro Cys Thr Pro Ser Leu Cys Glu His Gly
770 775 780 Gly His Cys Glu Ser Asp Pro Asp Arg Leu Thr Val Cys Ser
Cys Pro 785 790 795 800 Pro Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp
Val Asp Glu Cys Ala 805 810 815 Gly Ala Ser Pro Cys Gly Pro His Gly
Thr Cys Thr Asn Leu Pro Gly 820 825 830 Asn Phe Arg Cys Ile Cys His
Arg Gly Tyr Thr Gly Pro Phe Cys Asp 835 840 845 Gln Asp Ile Asp Asp
Cys Asp Pro Asn Pro Cys Leu His Gly Gly Ser 850 855 860 Cys Gln Asp
Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Asp Gly Phe 865 870 875 880
Ala Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Ser Pro 885
890 895 Cys Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys
Ala 900 905 910 Cys Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Ile Asp
Leu Pro Asp 915 920 925 Cys Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr
Cys Val Asp Gly Val 930 935 940 Ser Ser Phe Ser Cys Leu Cys Arg Pro
Gly Tyr Thr Gly Thr His Cys 945 950 955 960 Gln Tyr Glu Ala Asp Pro
Cys Phe Ser Arg Pro Cys Leu His Gly Gly 965 970 975 Ile Cys Asn Pro
Thr His Pro Gly Phe Glu Cys Thr Cys Arg Glu Gly 980 985 990 Phe Thr
Gly Ser Gln Cys Gln Asn Pro Val Asp Trp Cys Ser Gln Ala 995 1000
1005 Pro Cys Gln Asn Gly Gly Arg Cys Val Gln Thr Gly Ala Tyr Cys
1010 1015 1020 Ile Cys Pro Pro Gly Trp Ser Gly Arg Leu Cys Asp Ile
Gln Ser 1025 1030 1035 Leu Pro Cys Thr Glu Ala Ala Ala Gln Met Gly
Val Arg Leu Glu 1040 1045 1050 Gln Leu Cys Gln Glu Gly Gly Lys Cys
Ile Asp Lys Gly Arg Ser 1055 1060 1065 His Tyr Cys Val Cys Pro Glu
Gly Arg Thr Gly Ser His Cys Glu 1070 1075 1080 His Glu Val Asp Pro
Cys Thr Ala Gln Pro Cys Gln His Gly Gly 1085 1090 1095 Thr Cys Arg
Gly Tyr Met Gly Gly Tyr Val Cys Glu Cys Pro Ala 1100 1105 1110 Gly
Tyr Ala Gly Asp Ser Cys Glu Asp Asn Ile Asp Glu Cys Ala 1115 1120
1125 Ser Gln Pro Cys Gln Asn Gly Gly Ser Cys Ile Asp Leu Val Ala
1130 1135 1140 Arg Tyr Leu Cys Ser Cys Pro Pro Gly Thr Leu Gly Val
Leu Cys 1145 1150 1155 Glu Ile Asn Glu Asp Asp Cys Asp Leu Gly Pro
Ser Leu Asp Ser 1160 1165 1170 Gly Val Gln Cys Leu His Asn Gly Thr
Cys Val Asp Leu Val Gly 1175 1180 1185 Gly Phe Arg Cys Asn Cys Pro
Pro Gly Tyr Thr Gly Leu His Cys 1190 1195 1200 Glu Ala Asp Ile Asn
Glu Cys Arg Pro Gly Ala Cys His Ala Ala 1205 1210 1215 His Thr Arg
Asp Cys Leu Gln Asp Pro Gly Gly His Phe Arg Cys 1220 1225 1230 Val
Cys His Pro Gly Phe Thr Gly Pro Arg Cys Gln Ile Ala Leu 1235 1240
1245 Ser Pro Cys Glu Ser Gln Pro Cys Gln His Gly Gly Gln Cys Arg
1250 1255 1260 His Ser Leu Gly Arg Gly Gly Gly Leu Thr Phe Thr Cys
His Cys 1265 1270 1275 Val Pro Pro Phe Trp Gly Leu Arg Cys Glu Arg
Val Ala Arg Ser 1280 1285 1290 Cys Arg Glu Leu Gln Cys Pro Val Gly
Ile Pro Cys Gln Gln Thr 1295 1300 1305 Ala Arg Gly Pro Arg Cys Ala
Cys Pro Pro Gly Leu Ser Gly Pro 1310 1315 1320 Ser Cys Arg Val Ser
Arg Ala Ser Pro Ser Gly Ala Thr Asn Ala 1325 1330 1335 Ser Cys Ala
Ser Ala Pro Cys Leu His Gly Gly Ser Cys Leu Pro 1340 1345 1350 Val
Gln Ser Val Pro Phe Phe Arg Cys Val Cys Ala Pro Gly Trp 1355 1360
1365 Gly Gly Pro Arg Cys Glu Thr Pro Ser Ala Ala Pro Glu Val Pro
1370 1375 1380 Glu Glu Pro Arg Cys Pro Arg Ala Ala Cys Gln Ala Lys
Arg Gly 1385 1390 1395 Asp Gln Asn Cys Asp Arg Glu Cys Asn Thr Pro
Gly Cys Gly Trp 1400 1405 1410 Asp Gly Gly Asp Cys Ser Leu Asn Val
Asp Asp Pro Trp Arg Gln 1415 1420 1425 Cys Glu Ala Leu Gln Cys Trp
Arg Leu Phe Asn Asn Ser Arg Cys 1430 1435 1440 Asp Pro Ala Cys Ser
Ser Pro Ala Cys Leu Tyr Asp Asn Phe Asp 1445 1450 1455 Cys Tyr Ser
Gly Gly Arg Asp Arg Thr Cys Asn Pro Val Tyr Glu 1460 1465 1470 Lys
Tyr Cys Ala Asp His Phe Ala Asp Gly Arg Cys Asp Gln Gly 1475 1480
1485 Cys Asn Thr Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ser
1490 1495 1500 Glu Val Pro Ala Leu Leu Ala Arg Gly Val Leu Val Leu
Thr Val 1505 1510 1515 Leu Leu Pro Pro Glu Glu Leu Leu Arg Ser Ser
Ala Asp Phe Leu 1520 1525 1530 Gln Arg Leu Ser Ala Ile Leu Arg Thr
Ser Leu Arg Phe Arg Leu 1535 1540 1545 Asp Ala Arg Gly Gln Ala Met
Val Phe Pro Tyr His Arg Pro Ser 1550 1555 1560 Pro Gly Ser Glu Ser
Arg Val Arg Arg Glu Leu Gly Pro Glu Val 1565 1570 1575 Ile Gly Ser
Val Val Met Leu Glu Ile Asp Asn Arg Leu Cys Leu 1580 1585 1590 Gln
Ser Ala Glu Asn Asp His Cys Phe Pro Asp Ala Gln Ser Ala 1595 1600
1605 Ala Asp Tyr Leu Gly Ala Leu Ser Ala Val Glu Arg Leu Asp Phe
1610 1615 1620 Pro Tyr Pro Leu Arg Asp Val Arg Gly Glu Pro Leu Glu
Ala Pro 1625 1630 1635 Glu Gln Ser Val Pro Leu Leu Pro Leu Leu Val
Ala Gly Ala Val 1640 1645 1650 Phe Leu Leu Ile Ile Phe Ile Leu Gly
Val Met Val Ala Arg Arg 1655 1660 1665 Lys Arg Glu His Ser Thr Leu
Trp Phe Pro Glu Gly Phe Ala Leu 1670 1675 1680 His Lys Asp Ile Ala
Ala Gly His Lys Gly Arg Arg Glu Pro Val 1685 1690 1695 Gly Gln Asp
Ala Leu Gly Met Lys Asn Met Ala Lys Gly Glu Ser 1700 1705 1710 Leu
Met Gly Glu Val Val Thr Asp Leu Asn Asp Ser Glu Cys Pro 1715 1720
1725 Glu Ala Lys Arg Leu Lys Val Glu Glu Pro Gly Met Gly Ala Glu
1730 1735 1740 Glu Pro Glu Asp Cys Arg Gln Trp Thr Gln His His Leu
Val Ala 1745 1750 1755 Ala Asp Ile Arg Val Ala Pro Ala Thr Ala Leu
Thr Pro Pro Gln 1760 1765 1770 Gly Asp Ala Asp Ala Asp Gly Val Asp
Val Asn Val Arg Gly Pro 1775 1780 1785 Asp Gly Phe Thr Pro Leu Met
Leu Ala Ser Phe Cys Gly Gly Ala 1790 1795 1800 Leu Glu Pro Met Pro
Ala Glu Glu Asp Glu Ala Asp Asp Thr Ser 1805 1810 1815 Ala Ser Ile
Ile Ser Asp Leu Ile Cys Gln Gly Ala Gln Leu Gly 1820 1825 1830 Ala
Arg Thr Asp Arg Thr Gly Glu Thr Ala Leu His Leu Ala Ala 1835 1840
1845 Arg Tyr Ala Arg Ala Asp Ala Ala Lys Arg Leu Leu Asp Ala Gly
1850 1855 1860 Ala Asp Thr Asn Ala Gln Asp His Ser Gly Arg Thr Pro
Leu His 1865 1870 1875 Thr Ala Val Thr Ala Asp Ala Gln Gly Val Phe
Gln Ile Leu Ile 1880 1885 1890 Arg Asn Arg Ser Thr Asp Leu Asp Ala
Arg Met Ala Asp Gly Ser 1895 1900 1905 Thr Ala Leu Ile Leu Ala Ala
Arg Leu Ala Val Glu Gly Met Val 1910 1915 1920 Glu Glu Leu Ile Ala
Ser His Ala Asp Val Asn Ala Val Asp Glu 1925 1930 1935 Leu Gly Lys
Ser Ala Leu His Trp Ala Ala Ala Val Asn Asn Val 1940 1945 1950 Glu
Ala Thr Leu Ala Leu Leu Lys Asn Gly Ala Asn Lys Asp Met 1955 1960
1965 Gln Asp Ser Lys Glu Glu Thr Pro Leu Phe Leu Ala Ala Arg Glu
1970 1975 1980 Gly Ser Tyr Glu Ala Ala Lys Leu Leu Leu Asp His Leu
Ala Asn 1985 1990 1995 Arg Glu Ile Thr Asp His Leu Asp Arg Leu Pro
Arg Asp Val Ala 2000 2005 2010 Gln Glu Arg Leu His Gln Asp Ile Val
Arg Leu Leu Asp Gln Pro 2015 2020 2025 Ser Gly Pro Arg Ser Pro Ser
Gly Pro His Gly Leu Gly Pro Leu 2030 2035 2040 Leu Cys Pro Pro Gly
Ala Phe Leu Pro Gly Leu Lys Ala Val Gln 2045 2050 2055 Ser Gly Thr
Lys Lys Ser Arg Arg Pro Pro Gly Lys Thr Gly Leu 2060 2065 2070 Gly
Pro Gln Gly Thr Arg Gly Arg Gly Lys Lys Leu Thr Leu Ala 2075 2080
2085 Cys Pro Gly Pro Leu Ala Asp Ser Ser Val Thr Leu Ser Pro Val
2090 2095 2100 Asp Ser Leu Asp Ser Pro Arg Pro Phe Ser Gly Pro Pro
Ala Ser 2105 2110 2115 Pro Gly Gly Phe Pro Leu Glu Gly Pro Tyr Ala
Thr Thr Ala Thr 2120 2125 2130 Ala Val Ser Leu Ala Gln Leu Gly Ala
Ser Arg Ala Gly Pro Leu 2135 2140 2145 Gly Arg Gln Pro Pro Gly Gly
Cys Val Leu Ser Phe Gly Leu Leu 2150 2155 2160 Asn Pro Val Ala Val
Pro Leu Asp Trp Ala Arg Leu Pro Pro Pro 2165 2170 2175 Ala Pro Pro
Gly Pro Ser Phe Leu Leu Pro Leu Ala Pro Gly Pro 2180 2185 2190 Gln
Leu Leu Asn Pro Gly Ala Pro Val Ser Pro Gln Glu Arg Pro 2195 2200
2205 Pro Pro Tyr Leu Ala Ala Pro Gly His Gly Glu Glu Tyr Pro Ala
2210
2215 2220 Ala Gly Thr Arg Ser Ser Pro Thr Lys Ala Arg Phe Leu Arg
Val 2225 2230 2235 Pro Ser Glu His Pro Tyr Leu Thr Pro Ser Pro Glu
Ser Pro Glu 2240 2245 2250 His Trp Ala Ser Pro Ser Pro Pro Ser Leu
Ser Asp Trp Ser Asp 2255 2260 2265 Ser Thr Pro Ser Pro Ala Thr Ala
Thr Asn Ala Thr Ala Ser Gly 2270 2275 2280 Ala Leu Pro Ala Gln Pro
His Pro Ile Ser Val Pro Ser Leu Pro 2285 2290 2295 Gln Ser Gln Thr
Gln Leu Gly Pro Gln Pro Glu Val Thr Pro Lys 2300 2305 2310 Arg Gln
Val Met Ala Glx 2315 4 2002 PRT Homo sapiens 4 Met Gln Pro Pro Ser
Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Cys 1 5 10 15 Val Ser Val
Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro Glu 20 25 30 Pro
Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln Gly 35 40
45 Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe Pro
50 55 60 Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser
Cys Gln 65 70 75 80 Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser
Pro Ser Pro Leu 85 90 95 Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro
Gly Phe Thr Gly Glu Arg 100 105 110 Cys Gln Ala Lys Leu Glu Asp Pro
Cys Pro Pro Ser Phe Cys Ser Lys 115 120 125 Arg Gly Arg Cys His Ile
Gln Ala Ser Gly Arg Pro Gln Cys Ser Cys 130 135 140 Met Pro Gly Trp
Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys Ser 145 150 155 160 Ala
Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro Gln 165 170
175 Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu Arg
180 185 190 Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys
Gly Thr 195 200 205 Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu
Cys Pro Val Gly 210 215 220 Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala
Gly Pro Cys Pro Pro Arg 225 230 235 240 Gly Cys Ser Asn Gly Gly Thr
Cys Gln Leu Met Pro Glu Lys Asp Ser 245 250 255 Thr Phe His Leu Cys
Leu Cys Pro Pro Gly Phe Ile Gly Pro Gly Cys 260 265 270 Glu Val Asn
Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly Gly 275 280 285 Thr
Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu Thr 290 295
300 Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Ala Gln
305 310 315 320 Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn
Ser Ala Gly 325 330 335 Ser Phe His Cys Val Cys Val Ser Gly Trp Gly
Gly Thr Ser Cys Glu 340 345 350 Glu Asn Leu Asp Asp Cys Ile Ala Ala
Thr Cys Ala Pro Gly Ser Thr 355 360 365 Cys Ile Asp Arg Val Gly Ser
Phe Ser Cys Leu Cys Pro Pro Gly Arg 370 375 380 Thr Gly Leu Leu Cys
His Leu Glu Asp Met Cys Leu Ser Gln Pro Cys 385 390 395 400 His Gly
Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr Leu 405 410 415
Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp Leu 420
425 430 Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His
Gly 435 440 445 Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu
Cys Pro Pro 450 455 460 Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His
Asn Glu Cys Leu Ser 465 470 475 480 Gln Pro Cys His Pro Gly Ser Thr
Cys Leu Asp Leu Leu Ala Thr Phe 485 490 495 His Cys Leu Cys Pro Pro
Gly Leu Glu Gly Gln Leu Cys Glu Val Glu 500 505 510 Thr Asn Glu Cys
Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys His 515 520 525 Asp Leu
Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser Gly 530 535 540
Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys Ala 545
550 555 560 Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys
Lys Cys 565 570 575 Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu
Val Asp Glu Cys 580 585 590 Leu Ser Asp Pro Cys Pro Val Gly Ala Ser
Cys Leu Asp Leu Pro Gly 595 600 605 Ala Phe Phe Cys Leu Cys Pro Ser
Gly Phe Thr Gly Gln Leu Cys Glu 610 615 620 Val Pro Leu Cys Ala Pro
Asn Leu Cys Gln Pro Lys Gln Ile Cys Lys 625 630 635 640 Asp Gln Lys
Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro Gly 645 650 655 Cys
Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys Gln 660 665
670 Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys Glu
675 680 685 Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly
Gly Thr 690 695 700 Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys
Pro Thr Gly Tyr 705 710 715 720 Thr Gly Pro Thr Cys Ser Glu Glu Met
Thr Ala Cys His Ser Gly Pro 725 730 735 Cys Leu Asn Gly Gly Ser Cys
Asn Pro Ser Pro Gly Gly Tyr Tyr Cys 740 745 750 Thr Cys Pro Pro Ser
His Thr Gly Pro Gln Cys Gln Thr Ser Thr Asp 755 760 765 Tyr Cys Val
Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn Arg 770 775 780 Pro
Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro Arg 785 790
795 800 Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg
Asn 805 810 815 Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys
Leu Cys Pro 820 825 830 Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu
Met Asp Leu Cys Ala 835 840 845 Gln Lys Pro Cys Pro Arg Asn Ser His
Cys Leu Gln Thr Gly Pro Ser 850 855 860 Phe His Cys Leu Cys Leu Gln
Gly Trp Thr Gly Pro Leu Cys Asn Leu 865 870 875 880 Pro Leu Ser Ser
Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp Val 885 890 895 Ser Ser
Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro Ser 900 905 910
Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln Asp 915
920 925 His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr
Cys 930 935 940 Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro
Gly Tyr Asp 945 950 955 960 Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala
Cys Gln Ser Gln Pro Cys 965 970 975 His Asn His Gly Thr Cys Thr Pro
Lys Pro Gly Gly Phe His Cys Ala 980 985 990 Cys Pro Pro Gly Phe Val
Gly Leu Arg Cys Glu Gly Asp Val Asp Glu 995 1000 1005 Cys Leu Asp
Gln Pro Cys His Pro Thr Gly Thr Ala Ala Cys His 1010 1015 1020 Ser
Leu Ala Asn Ala Phe Tyr Cys Gln Cys Leu Pro Gly His Thr 1025 1030
1035 Gly Gln Trp Cys Glu Val Glu Ile Asp Pro Cys His Ser Gln Pro
1040 1045 1050 Cys Phe His Gly Gly Thr Cys Glu Ala Thr Ala Gly Ser
Pro Leu 1055 1060 1065 Gly Phe Ile Cys His Cys Pro Lys Gly Phe Glu
Gly Pro Thr Cys 1070 1075 1080 Ser His Arg Ala Pro Ser Cys Gly Phe
His His Cys His His Gly 1085 1090 1095 Gly Leu Cys Leu Pro Ser Pro
Lys Pro Gly Phe Pro Pro Arg Cys 1100 1105 1110 Ala Cys Leu Ser Gly
Tyr Gly Gly Pro Asp Cys Leu Thr Pro Pro 1115 1120 1125 Ala Pro Lys
Gly Cys Gly Pro Pro Ser Pro Cys Leu Tyr Asn Gly 1130 1135 1140 Ser
Cys Ser Glu Thr Thr Gly Leu Gly Gly Pro Gly Phe Arg Cys 1145 1150
1155 Ser Cys Pro His Ser Ser Pro Gly Pro Arg Cys Gln Lys Pro Gly
1160 1165 1170 Ala Lys Gly Cys Glu Gly Arg Ser Gly Asp Gly Ala Cys
Asp Ala 1175 1180 1185 Gly Cys Ser Gly Pro Gly Gly Asn Trp Asp Gly
Gly Asp Cys Ser 1190 1195 1200 Leu Gly Val Pro Asp Pro Trp Lys Gly
Cys Pro Ser His Ser Arg 1205 1210 1215 Cys Trp Leu Leu Phe Arg Asp
Gly Gln Cys His Pro Gln Cys Asp 1220 1225 1230 Ser Glu Glu Cys Leu
Phe Asp Gly Tyr Asp Cys Glu Thr Pro Pro 1235 1240 1245 Ala Cys Thr
Pro Ala Tyr Asp Gln Tyr Cys His Asp His Phe His 1250 1255 1260 Asn
Gly His Cys Glu Lys Gly Cys Asn Thr Ala Glu Cys Gly Trp 1265 1270
1275 Asp Gly Gly Asp Cys Arg Pro Glu Asp Gly Asp Pro Glu Trp Gly
1280 1285 1290 Pro Ser Leu Ala Leu Leu Val Val Leu Ser Pro Pro Ala
Leu Asp 1295 1300 1305 Gln Gln Leu Phe Ala Leu Ala Arg Val Leu Ser
Leu Thr Leu Arg 1310 1315 1320 Val Gly Leu Trp Val Arg Lys Asp Arg
Asp Gly Arg Asp Met Val 1325 1330 1335 Tyr Pro Tyr Pro Gly Ala Arg
Ala Glu Glu Lys Leu Gly Gly Thr 1340 1345 1350 Arg Asp Pro Thr Tyr
Gln Glu Arg Ala Ala Pro Gln Thr Gln Pro 1355 1360 1365 Leu Gly Lys
Glu Thr Asp Ser Leu Ser Ala Gly Phe Val Val Val 1370 1375 1380 Met
Gly Val Asp Leu Ser Arg Cys Gly Pro Asp His Pro Ala Ser 1385 1390
1395 Arg Cys Pro Trp Asp Pro Gly Leu Leu Leu Arg Phe Leu Ala Ala
1400 1405 1410 Met Ala Ala Val Gly Ala Leu Glu Pro Leu Leu Pro Gly
Pro Leu 1415 1420 1425 Leu Ala Val His Pro His Ala Gly Thr Ala Pro
Pro Ala Asn Gln 1430 1435 1440 Leu Pro Trp Pro Val Leu Cys Ser Pro
Val Ala Gly Val Ile Leu 1445 1450 1455 Leu Ala Leu Gly Ala Leu Leu
Val Leu Gln Leu Ile Arg Arg Arg 1460 1465 1470 Arg Arg Glu His Gly
Ala Leu Trp Leu Pro Pro Gly Phe Thr Arg 1475 1480 1485 Arg Pro Arg
Thr Gln Ser Ala Pro His Arg Arg Arg Pro Pro Leu 1490 1495 1500 Gly
Glu Asp Ser Ile Gly Leu Lys Ala Leu Lys Pro Lys Ala Glu 1505 1510
1515 Val Asp Glu Asp Gly Val Val Met Cys Ser Gly Pro Glu Glu Gly
1520 1525 1530 Glu Glu Val Gly Gln Ala Glu Glu Thr Gly Pro Pro Ser
Thr Cys 1535 1540 1545 Gln Leu Trp Ser Leu Ser Gly Gly Cys Gly Ala
Leu Pro Gln Ala 1550 1555 1560 Ala Met Leu Thr Pro Pro Gln Glu Ser
Glu Met Glu Ala Pro Asp 1565 1570 1575 Leu Asp Thr Arg Gly Pro Asp
Gly Val Thr Pro Leu Met Ser Ala 1580 1585 1590 Val Cys Cys Gly Glu
Val Gln Ser Gly Thr Phe Gln Gly Ala Trp 1595 1600 1605 Leu Gly Cys
Pro Glu Pro Trp Glu Pro Leu Leu Asp Gly Gly Ala 1610 1615 1620 Cys
Pro Gln Ala His Thr Val Gly Thr Gly Glu Thr Pro Leu His 1625 1630
1635 Leu Ala Ala Arg Phe Ser Arg Pro Thr Ala Ala Arg Arg Leu Leu
1640 1645 1650 Glu Ala Gly Ala Asn Pro Asn Gln Pro Asp Arg Ala Gly
Arg Thr 1655 1660 1665 Pro Leu His Ala Ala Val Ala Ala Asp Ala Arg
Glu Val Cys Gln 1670 1675 1680 Leu Leu Leu Arg Ser Arg Gln Thr Ala
Val Asp Ala Arg Thr Glu 1685 1690 1695 Asp Gly Thr Thr Pro Leu Met
Leu Ala Ala Arg Leu Ala Val Glu 1700 1705 1710 Asp Leu Val Glu Glu
Leu Ile Ala Ala Gln Ala Asp Val Gly Ala 1715 1720 1725 Arg Asp Lys
Trp Gly Lys Thr Ala Leu His Trp Ala Ala Ala Val 1730 1735 1740 Asn
Asn Ala Arg Ala Ala Arg Ser Leu Leu Gln Ala Gly Ala Asp 1745 1750
1755 Lys Asp Ala Gln Asp Asn Arg Glu Gln Thr Pro Leu Phe Leu Ala
1760 1765 1770 Ala Arg Glu Gly Ala Val Glu Val Ala Gln Leu Leu Leu
Gly Leu 1775 1780 1785 Gly Ala Ala Arg Glu Leu Arg Asp Gln Ala Gly
Leu Ala Pro Ala 1790 1795 1800 Asp Val Ala His Gln Arg Asn His Trp
Asp Leu Leu Thr Leu Leu 1805 1810 1815 Glu Gly Ala Gly Pro Pro Glu
Ala Arg His Lys Ala Thr Pro Gly 1820 1825 1830 Arg Glu Ala Gly Pro
Phe Pro Arg Ala Arg Thr Val Ser Val Ser 1835 1840 1845 Val Pro Pro
His Gly Gly Gly Ala Leu Pro Arg Cys Arg Thr Leu 1850 1855 1860 Ser
Ala Gly Ala Gly Pro Arg Gly Gly Gly Ala Cys Leu Gln Ala 1865 1870
1875 Arg Thr Trp Ser Val Asp Leu Ala Ala Arg Gly Gly Gly Ala Tyr
1880 1885 1890 Ser His Cys Arg Ser Leu Ser Gly Val Gly Ala Gly Gly
Gly Pro 1895 1900 1905 Thr Pro Arg Gly Arg Arg Phe Ser Ala Gly Met
Arg Gly Pro Arg 1910 1915 1920 Pro Asn Pro Ala Ile Met Arg Gly Arg
Tyr Gly Val Ala Ala Gly 1925 1930 1935 Arg Gly Gly Arg Val Ser Thr
Asp Asp Trp Pro Cys Asp Trp Val 1940 1945 1950 Ala Leu Gly Ala Cys
Gly Ser Ala Ser Asn Ile Pro Ile Pro Pro 1955 1960 1965 Pro Cys Leu
Thr Pro Ser Pro Glu Arg Gly Ser Pro Gln Leu Asp 1970 1975 1980 Cys
Gly Pro Pro Ala Leu Gln Glu Met Pro Ile Asn Gln Gly Gly 1985 1990
1995 Glu Gly Lys Lys 2000 5 48 PRT Homo sapiens 5 Ala Ala Gly Thr
Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn
Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His 20 25 30
Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe 35
40 45 6 48 PRT Rattus rattus 6 Ala Ala Gly Thr Leu Val Leu Val Val
Leu Leu Pro Pro Asp Gln Leu 1 5 10 15 Arg Asn Asn Ser Phe His Phe
Leu Arg Asp Val Ser His Val Leu His 20 25 30 Thr Asn Val Val Phe
Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe 35 40 45 7 48 PRT Mus
musculus 7 Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp
Gln Leu 1 5 10 15 Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser
His Val Leu His 20 25 30 Thr Asn Val Val Phe Lys Arg Asp Ala His
Gly Gln Gln Met Ile Phe 35 40 45 8 48 PRT Gallus gallus 8 Ala Asp
Gly Thr Leu Val Val Val Val Leu Ile Thr Pro Glu Asn Leu 1 5 10 15
Lys Asn Asn Ser Phe Asn Phe Leu Arg Glu Leu Ser Arg Val Leu His 20
25 30 Thr Asn Val Val Phe Lys Lys Asn Ala His Gly Gln Gln Met Ile
Phe 35 40 45 9 48 PRT Xenopus laevis 9 Ala Glu Gly Thr Leu Val Leu
Val Val Leu Met Pro Pro Glu Arg Leu 1 5 10 15 Lys Asn Asn Ser Val
Asn Phe Leu Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val
Val Phe Lys Lys Asp Ala His Gly Gln Gln Met Ile Phe 35 40 45 10 48
PRT Danio rerio 10 Ala Val Gly Leu Leu Val Val Val Val His Ile His
Pro Asp Gln Leu 1 5 10 15 Arg Asn Asn Ser Phe Gly Phe Leu Arg Glu
Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Phe Arg Arg Asp
Ala His Gly Gln Gln Met Ile Phe 35 40 45 11 48 PRT artificial
sequence consensus sequence misc_feature (2)..(2) Xaa=Val, Glu, Asp
or
Ala misc_feature (4)..(4) Xaa=Leu or Thr misc_feature (7)..(7)
Xaa=Val or Leu misc_feature (10)..(10) Xaa=His or Leu misc_feature
(11)..(11) Xaa=Ile, Met or Leu misc_feature (12)..(12) Xaa=His, Pro
or Thr misc_feature (14)..(14) Xaa=Asp or Glu misc_feature
(15)..(15) Xaa=Gln, Arg or Asn misc_feature (17)..(17) Xaa=Arg or
Lys misc_feature (19)..(19) Xaa=Asn or Ser misc_feature (21)..(21)
Xaa=Phe or Val misc_feature (22)..(22) Xaa=Gly, Asn or His
misc_feature (26)..(26) Xaa=Asp or Glu misc_feature (27)..(27)
Xaa=Leu or Val misc_feature (29)..(29) Xaa=Arg or His misc_feature
(38)..(38) Xaa=Arg or Lys misc_feature (39)..(39) Xaa=Arg or Lys 11
Ala Xaa Gly Xaa Leu Val Xaa Val Val Xaa Xaa Xaa Pro Xaa Xaa Leu 1 5
10 15 Xaa Asn Xaa Ser Xaa Xaa Phe Leu Arg Xaa Xaa Ser Xaa Val Leu
His 20 25 30 Thr Asn Val Val Phe Xaa Xaa Asp Ala His Gly Gln Gln
Met Ile Phe 35 40 45 12 48 PRT Homo sapiens 12 Ala Ala Gly Thr Leu
Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser
Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Pro His 20 25 30 Thr
Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe 35 40
45 13 48 PRT Homo sapiens 13 Ala Ala Gly Thr Leu Val Val Val Val
Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe
Pro Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Phe
Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe 35 40 45 14 48 PRT Homo
sapiens 14 Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu
Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Pro Arg Glu Leu Ser
Arg Val Leu His 20 25 30 Thr Asn Val Val Phe Lys Arg Val Ala His
Gly Gln Gln Met Ile Phe 35 40 45 15 48 PRT Homo sapiens 15 Ala Ala
Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15
Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Pro Val Leu His 20
25 30 Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile
Phe 35 40 45 16 48 PRT Homo sapiens 16 Ala Ala Gly Thr Pro Val Val
Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe
His Phe Leu Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val
Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe 35 40 45 17 47
PRT Homo sapiens 17 Ala Ala Gly Thr Leu Val Val Val Leu Met Pro Pro
Glu Gln Leu Arg 1 5 10 15 Asn Ser Ser Phe His Phe Leu Arg Glu Leu
Ser Arg Val Leu His Thr 20 25 30 Asn Val Val Phe Lys Arg Asp Ala
His Gly Gln Gln Met Ile Phe 35 40 45 18 48 PRT Homo sapiens 18 Ala
Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10
15 Arg Asn Ser Ser Phe His Ser Leu Arg Glu Leu Ser Arg Val Leu His
20 25 30 Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met
Ile Phe 35 40 45 19 48 PRT Homo sapiens 19 Ala Ala Gly Thr Leu Val
Val Val Val Leu Met Pro Pro Glu Gln Pro 1 5 10 15 Arg Asn Ser Ser
Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn
Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe 35 40 45 20
48 PRT Homo sapiens 20 Ala Ala Gly Thr Leu Val Val Val Val Leu Met
Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg
Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Phe Lys Ser
Asp Ala His Gly Gln Gln Met Ile Phe 35 40 45 21 47 PRT Homo sapiens
21 Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu
1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val
Leu His 20 25 30 Thr Asn Val Phe Lys Arg Asp Ala His Gly Gln Gln
Met Ile Phe 35 40 45 22 46 PRT Homo sapiens 22 Ala Ala Gly Thr Leu
Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser
Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr
Asn Val Val Phe Lys Thr His Gly Gln Gln Met Ile Phe 35 40 45 23 53
PRT Homo sapiens 23 Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro
Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg Glu
Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Phe Lys Arg Asp
Ala His Gly Gln Gln Met Ile Phe 35 40 45 Pro Pro Gly Gly Gly 50 24
53 PRT Homo sapiens 24 Ala Ala Gly Thr Leu Val Val Val Val Leu Met
Pro Pro Ala Gln Gln 1 5 10 15 Leu Arg Asn Ser Ser Phe His Phe Leu
Arg Glu Leu Ser Arg Val Leu 20 25 30 His Thr Asn Val Val Phe Lys
Arg Asp Ala His Gly Gln Gln Met Ile 35 40 45 Phe Pro Tyr Tyr Gly 50
25 53 PRT Homo sapiens 25 Ala Ala Gly Thr Leu Val Val Val Val Leu
Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu
Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Leu Gly
Arg Arg Asp Ala His Gly Gln Gln Met Ile 35 40 45 Phe Pro Tyr Tyr
Gly 50 26 53 PRT Homo sapiens 26 Ala Ala Gly Thr Leu Val Val Val
Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His
Leu Ala Leu Arg Glu Leu Ser Arg Val Leu 20 25 30 His Thr Asn Val
Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile 35 40 45 Phe Pro
Tyr Tyr Gly 50 27 55 PRT Homo sapiens 27 Ala Ala Gly Thr Leu Val
Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser
Phe His Phe Leu Arg Glu Lys Glu Asp Leu Ser Arg 20 25 30 Val Leu
His Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln 35 40 45
Met Ile Phe Pro Tyr Tyr Gly 50 55 28 56 PRT Homo sapiens 28 Ala Ala
Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15
Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His 20
25 30 Thr Asn Val Val Phe Lys Ser Met Pro Pro Arg Asp Ala His Gly
Gln 35 40 45 Gln Met Ile Phe Pro Tyr Tyr Gly 50 55 29 53 PRT Homo
sapiens 29 Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu
Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Thr Ala Leu Arg Glu Leu
Ser Arg Val Leu 20 25 30 His Thr Asn Val Val Phe Lys Arg Asp Ala
His Gly Gln Gln Met Ile 35 40 45 Phe Pro Tyr Tyr Gly 50 30 88 PRT
Homo sapiens 30 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln
Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser
Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro Leu
His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser
Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His
Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met
Gln Gln Gln Asn Leu 85 31 84 PRT Homo sapiens 31 Trp Leu Ser Arg
Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg
Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30
Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35
40 45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg
Leu 50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln
Pro Gln Asn 65 70 75 80 Leu Gln Met Gln 32 83 PRT Homo sapiens 32
Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5
10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro
Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu
Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu
Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr
Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met 33 31 PRT Homo
sapiens 33 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr
Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr
Gln Ala Pro 20 25 30 34 166 PRT Homo sapiens 34 Trp Leu Ser Arg Leu
Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly
Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu
Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35 40
45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu
50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro
Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn
Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro
Gln Pro His Leu Gly Val 100 105 110 Ser Ser Ala Ala Ser Gly His Leu
Gly Arg Ser Phe Leu Ser Gly Glu 115 120 125 Pro Ser Gln Ala Asp Val
Gln Pro Leu Gly Pro Ser Ser Leu Ala Val 130 135 140 His Thr Ile Leu
Pro Gln Glu Ser Pro Ala Leu Pro Thr Ser Leu Pro 145 150 155 160 Ser
Ser Leu Val Pro Pro 165 35 167 PRT Homo sapiens 35 Trp Leu Ser Arg
Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg
Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30
Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35
40 45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg
Leu 50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln
Pro Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala
Asn Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln Pro Pro Pro Pro Pro
Pro Gln Pro His Leu Gly Val 100 105 110 Ser Ser Ala Ala Ser Gly His
Leu Gly Arg Ser Phe Leu Ser Gly Glu 115 120 125 Pro Ser Gln Ala Asp
Val Gln Pro Leu Gly Pro Ser Ser Leu Ala Val 130 135 140 His Thr Ile
Leu Pro Gln Glu Ser Pro Ala Leu Pro Thr Ser Leu Pro 145 150 155 160
Ser Ser Leu Val Ala His Pro 165 36 167 PRT Homo sapiens 36 Trp Leu
Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5 10 15
Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser 20
25 30 Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu Ala Ala
Ser 35 40 45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser
Thr Arg Leu 50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln
Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln
Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln Pro Pro Pro
Pro Pro Pro Gln Pro His Leu Gly Val 100 105 110 Ser Ser Ala Ala Ser
Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu 115 120 125 Pro Ser Gln
Ala Asp Val Gln Pro Leu Gly Pro Ser Ser Leu Ala Val 130 135 140 His
Thr Ile Leu Pro Gln Glu Ser Pro Ala Leu Pro Thr Ser Gly Cys 145 150
155 160 His Pro Arg Trp Ser His Pro 165 37 156 PRT Homo sapiens 37
Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5
10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro
Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu
Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu
Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr
Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln Asn
Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln Pro
Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val 100 105 110 Ser Ser Ala
Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu 115 120 125 Pro
Ser Gln Ala Asp Val Gln Pro Leu Gly Pro Ser Ser Leu Ala Val 130 135
140 His Thr Ile Leu Pro Gln Glu Ser Pro Ala Leu Pro 145 150 155 38
166 PRT Homo sapiens 38 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro
Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro
Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly
Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met
Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln
Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu
Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90
95 Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val
100 105 110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser
Gly Glu 115 120 125 Pro Ser Gln Ala Asp Val Gln Pro Leu Gly Pro Ser
Ser Leu Ala Val 130 135 140 His Thr Ile Leu Pro Gln Glu Ser Pro Pro
Cys Pro Arg Arg Cys His 145 150 155 160 Pro Arg Trp Ser His Pro 165
39 150 PRT Homo sapiens 39 Trp Leu Ser Arg Leu Gln Ser Gly Met Val
Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly
Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val
Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln
Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr
Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80
Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85
90 95 Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly
Val 100 105 110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu
Ser Gly Glu 115 120 125 Pro Ser Gln Ala Asp Val Gln Pro Leu Gly Pro
Ser Ser Leu Ala Val 130 135 140 His Thr Ile Leu Pro Gln 145 150 40
170 PRT Homo sapiens 40 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro
Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro
Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly
Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met
Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln
Pro His Leu Val Gln Thr Gln
Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln Asn Leu
Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln Pro Pro
Pro Pro Pro Pro Gln Pro His Leu Gly Val 100 105 110 Ser Ser Ala Ala
Ser Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu 115 120 125 Pro Ser
Gln Ala Asp Leu Ser Arg Asp Leu Cys Ser His Trp Ala Pro 130 135 140
Ala Ala Trp Arg Cys Thr Leu Phe Cys Pro Arg Arg Ala Pro Pro Cys 145
150 155 160 Pro Arg Arg Cys His Pro Arg Trp Ser His 165 170 41 167
PRT Homo sapiens 41 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn
Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu
Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro
Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met
Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro
His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln
Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95
Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val 100
105 110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser Gly
Glu 115 120 125 Pro Ser Gln Ala Asp Cys Cys Ser His Trp Ala Pro Ala
Ala Trp Arg 130 135 140 Cys Thr Leu Phe Cys Pro Arg Arg Ala Pro Pro
Cys Pro Arg Arg Cys 145 150 155 160 His Pro Arg Trp Ser His Pro 165
42 170 PRT Homo sapiens 42 Trp Leu Ser Arg Leu Gln Ser Gly Met Val
Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly
Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val
Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln
Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr
Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80
Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85
90 95 Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly
Val 100 105 110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu
Ser Gly Glu 115 120 125 Pro Ser Gln Ala Glu Gly Arg Gly Arg Cys Ser
His Trp Ala Pro Ala 130 135 140 Ala Trp Arg Cys Thr Leu Phe Cys Pro
Arg Arg Ala Pro Pro Cys Pro 145 150 155 160 Arg Arg Cys His Pro Arg
Trp Ser His Pro 165 170 43 169 PRT Homo sapiens 43 Trp Leu Ser Arg
Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg
Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30
Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35
40 45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg
Leu 50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln
Pro Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala
Asn Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln Pro Pro Pro Pro Pro
Pro Gln Pro His Leu Gly Val 100 105 110 Ser Ser Ala Ala Ser Gly His
Leu Gly Arg Ser Phe Leu Ser Gly Glu 115 120 125 Pro Ser Gln Gly Gly
Gly Gly Met Gly Ser His Trp Ala Pro Ala Ala 130 135 140 Trp Arg Cys
Thr Leu Phe Cys Pro Arg Arg Ala Pro Pro Cys Pro Arg 145 150 155 160
Arg Cys His Pro Arg Trp Ser His Pro 165 44 167 PRT Homo sapiens 44
Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5
10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro
Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu
Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu
Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr
Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln Asn
Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln Pro
Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val 100 105 110 Ser Ser Ala
Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu 115 120 125 Glu
Arg Ala Arg Gln Thr Cys Ser His Trp Ala Pro Ala Ala Trp Arg 130 135
140 Cys Thr Leu Phe Cys Pro Arg Arg Ala Pro Pro Cys Pro Arg Arg Cys
145 150 155 160 His Pro Arg Trp Ser His Pro 165 45 168 PRT Homo
sapiens 45 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr
Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr
Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro Leu His
Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser Tyr
Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His Leu
Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met Gln
Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln Ser
Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val 100 105 110
Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu 115
120 125 Arg Val Arg Ala Arg Gln Thr Cys Ser His Trp Ala Pro Ala Ala
Trp 130 135 140 Arg Cys Thr Leu Phe Cys Pro Arg Arg Ala Pro Pro Cys
Pro Arg Arg 145 150 155 160 Cys His Pro Arg Trp Ser His Pro 165 46
128 PRT Homo sapiens 46 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro
Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro
Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly
Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met
Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln
Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu
Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90
95 Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val
100 105 110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser
Gly Glu 115 120 125 47 126 PRT Homo sapiens 47 Trp Leu Ser Arg Leu
Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly
Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu
Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35 40
45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu
50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro
Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn
Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro
Gln Pro His Leu Gly Val 100 105 110 Ser Ser Ala Ala Ser Gly His Leu
Gly Arg Ser Ala Pro Ser 115 120 125 48 112 PRT Homo sapiens 48 Trp
Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5 10
15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser
20 25 30 Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu Ala
Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro
Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr Gln
Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln Asn Leu
Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln Pro Pro
Pro Pro Pro Pro Gln Pro His Leu Ala Ala 100 105 110 49 113 PRT Homo
sapiens 49 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr
Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr
Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro Leu His
Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser Tyr
Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His Leu
Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met Gln
Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln Ser
Leu Gln Pro Arg His His His His His Ser Arg Thr Leu Val 100 105 110
Ala 50 96 PRT Homo sapiens 50 Trp Leu Ser Arg Leu Gln Ser Gly Met
Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro
Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met
Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser
Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala
Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70
75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln
Gln 85 90 95 51 93 PRT Homo sapiens 51 Trp Leu Ser Arg Leu Gln Ser
Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val
Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His
Gly Met Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala
Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55
60 Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn
65 70 75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile 85
90 52 275 PRT Homo sapiens 52 Trp Leu Ser Arg Leu Gln Ser Gly Met
Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro
Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met
Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser
Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala
Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70
75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln
Gln 85 90 95 Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His
Leu Gly Val 100 105 110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser
Phe Leu Ser Gly Glu 115 120 125 Pro Ser Gln Ala Asp Val Gln Pro Leu
Gly Pro Ser Ser Leu Ala Val 130 135 140 His Thr Ile Leu Pro Gln Glu
Ser Pro Ala Leu Pro Thr Ser Leu Pro 145 150 155 160 Ser Ser Leu Val
Pro Pro Val Thr Ala Ala Gln Phe Leu Thr Pro Pro 165 170 175 Ser Gln
His Ser Tyr Ser Ser Pro Val Asp Asn Thr Pro Ser His Gln 180 185 190
Leu Gln Val Pro Glu His Pro Phe Leu Thr Pro Ser Pro Asp Ser Gly 195
200 205 Pro Ala Arg Pro Arg Ile Pro Thr Ser Pro Thr Gly Pro Arg Ala
Ser 210 215 220 Pro Ala Leu Pro Pro Ala Cys Ser Pro Arg Ser Pro Ala
Phe Arg Arg 225 230 235 240 Pro Ser Ser Lys Arg Arg Ala Pro Arg Asp
Pro Gly Phe Leu Ser Gln 245 250 255 Ala Phe Gly Arg Leu Cys Ala Leu
Cys Gly Cys Gln Gly Arg Pro Glu 260 265 270 Glu Pro Phe 275 53 207
PRT Homo sapiens 53 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn
Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu
Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro
Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met
Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro
His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln
Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95
Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val 100
105 110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser Gly
Glu 115 120 125 Pro Ser Gln Ala Asp Val Gln Pro Leu Gly Pro Ser Ser
Leu Ala Val 130 135 140 His Thr Ile Leu Pro Gln Glu Ser Pro Ala Leu
Pro Thr Ser Leu Pro 145 150 155 160 Ser Ser Leu Val Pro Pro Val Thr
Ala Ala Gln Phe Leu Thr Pro Pro 165 170 175 Ser Gln His Ser Tyr Ser
Ser Pro Val Asp Asn Thr Pro Ser His Gln 180 185 190 Leu Gln Val Pro
Glu His Pro Phe Leu Thr Pro Ser Ser Val Pro 195 200 205 54 207 PRT
Homo sapiens 54 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln
Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser
Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro Leu
His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser
Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His
Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met
Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln
Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val 100 105
110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu
115 120 125 Pro Ser Gln Ala Asp Val Gln Pro Leu Gly Pro Ser Ser Leu
Ala Val 130 135 140 His Thr Ile Leu Pro Gln Glu Ser Pro Ala Leu Pro
Thr Ser Leu Pro 145 150 155 160 Ser Ser Leu Val Pro Pro Val Thr Ala
Ala Gln Phe Leu Thr Pro Pro 165 170 175 Ser Gln His Ser Tyr Ser Ser
Pro Val Asp Asn Thr Pro Ser His Gln 180 185 190 Leu Gln Val Pro Glu
His Pro Phe Leu Thr Pro Ser Arg Val Pro 195 200 205 55 205 PRT Homo
sapiens 55 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr
Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr
Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro Leu His
Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser Tyr
Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His Leu
Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met Gln
Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln Ser
Leu Gln Pro Pro Pro
Pro Pro Pro Gln Pro His Leu Gly Val 100 105 110 Ser Ser Ala Ala Ser
Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu 115 120 125 Pro Ser Gln
Ala Asp Val Gln Pro Leu Gly Pro Ser Ser Leu Ala Val 130 135 140 His
Thr Ile Leu Pro Gln Glu Ser Pro Ala Leu Pro Thr Ser Leu Pro 145 150
155 160 Ser Ser Leu Val Pro Pro Val Thr Ala Ala Gln Phe Leu Thr Pro
Pro 165 170 175 Ser Gln His Ser Tyr Ser Ser Pro Val Asp Asn Thr Pro
Ser His Gln 180 185 190 Leu Gln Val Pro Glu His Pro Phe Leu Thr Pro
Val Pro 195 200 205 56 199 PRT Homo sapiens 56 Trp Leu Ser Arg Leu
Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly
Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu
Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35 40
45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu
50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro
Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn
Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro
Gln Pro His Leu Gly Val 100 105 110 Ser Ser Ala Ala Ser Gly His Leu
Gly Arg Ser Phe Leu Ser Gly Glu 115 120 125 Pro Ser Gln Ala Asp Val
Gln Pro Leu Gly Pro Ser Ser Leu Ala Val 130 135 140 His Thr Ile Leu
Pro Gln Glu Ser Pro Ala Leu Pro Thr Ser Leu Pro 145 150 155 160 Ser
Ser Leu Val Pro Pro Val Thr Ala Ala Gln Phe Leu Thr Pro Pro 165 170
175 Ser Gln His Ser Tyr Ser Ser Pro Val Asp Asn Thr Pro Ser His Gln
180 185 190 Leu Gln Val Pro Glu Tyr Pro 195 57 196 PRT Homo sapiens
57 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro
1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala
Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser
Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly
Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His Leu Val Gln
Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln
Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln
Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val 100 105 110 Ser Ser
Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu 115 120 125
Pro Ser Gln Ala Asp Val Gln Pro Leu Gly Pro Ser Ser Leu Ala Val 130
135 140 His Thr Ile Leu Pro Gln Glu Ser Pro Ala Leu Pro Thr Ser Leu
Pro 145 150 155 160 Ser Ser Leu Val Pro Pro Val Thr Ala Ala Gln Phe
Leu Thr Pro Pro 165 170 175 Ser Gln His Ser Tyr Ser Ser Pro Val Asp
Asn Thr Pro Ser His Gln 180 185 190 Leu Gln Val Pro 195 58 195 PRT
Homo sapiens 58 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln
Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser
Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro Leu
His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser
Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His
Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met
Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln
Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val 100 105
110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu
115 120 125 Pro Ser Gln Ala Asp Val Gln Pro Leu Gly Pro Ser Ser Leu
Ala Val 130 135 140 His Thr Ile Leu Pro Gln Glu Ser Pro Ala Leu Pro
Thr Ser Leu Pro 145 150 155 160 Ser Ser Leu Val Pro Pro Val Thr Ala
Ala Gln Phe Leu Thr Pro Pro 165 170 175 Ser Gln His Ser Tyr Ser Ser
Gly Arg Gln His Pro Gln Pro Pro Ala 180 185 190 Thr Gly Ala 195 59
182 PRT Homo sapiens 59 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro
Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro
Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly
Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met
Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln
Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu
Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90
95 Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val
100 105 110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser
Gly Glu 115 120 125 Pro Ser Gln Ala Asp Val Gln Pro Leu Gly Pro Ser
Ser Leu Ala Val 130 135 140 His Thr Ile Leu Pro Gln Glu Ser Pro Ala
Leu Pro Thr Ser Leu Pro 145 150 155 160 Ser Ser Leu Val Pro Pro Val
Thr Ala Ala Gln Phe Leu Thr Pro Pro 165 170 175 Ser Gln His Ser Tyr
Ser 180 60 66 PRT Homo sapiens 60 Tyr Ser Ser Pro Val Asp Asn Thr
Pro Ser His Gln Leu Gln Val Pro 1 5 10 15 Glu His Pro Phe Leu Thr
Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser 20 25 30 Ser Ser Ser Pro
His Ser Asn Val Ser Asp Trp Ser Glu Gly Val Ser 35 40 45 Ser Pro
Pro Thr Ser Met Gln Ser Gln Ile Ala Arg Ile Pro Glu Ala 50 55 60
Phe Lys 65 61 57 PRT Danio rerio 61 Gly Ser Ile Val Tyr Leu Glu Ile
Asp Asn Arg Leu Cys Ser Gln Gly 1 5 10 15 Ser Asp Asp Cys Phe Arg
Asn Ala Asp Ser Ala Ala Glu Tyr Leu Gly 20 25 30 Ala Leu Ser Ala
Arg Glu Met Leu Arg Phe Pro Tyr Pro Ile Lys Glu 35 40 45 Val Thr
Ser Glu Lys Arg Glu Pro Ser 50 55 62 59 PRT Homo sapiens 62 Gly Ser
Val Val Met Leu Glu Ile Asp Asn Arg Leu Cys Leu Gln Ser 1 5 10 15
Ala Glu Asn Asp His Cys Phe Pro Asp Ala Gln Ser Ala Ala Asp Tyr 20
25 30 Leu Gly Ala Leu Ser Ala Val Glu Arg Leu Asp Phe Pro Tyr Pro
Leu 35 40 45 Arg Asp Val Arg Gly Glu Pro Leu Glu Ala Pro 50 55 63
57 PRT Mus musculus 63 Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg
Gln Cys Val Gln Ser 1 5 10 15 Ser Ser Gln Cys Phe Gln Ser Ala Thr
Asp Val Ala Ala Phe Leu Gly 20 25 30 Ala Leu Ala Ser Leu Gly Ser
Leu Asn Ile Pro Tyr Lys Ile Glu Ala 35 40 45 Val Lys Ser Glu Pro
Val Glu Pro Pro 50 55 64 57 PRT Rattus rattus 64 Gly Ser Ile Val
Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser 1 5 10 15 Ser Ser
Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly 20 25 30
Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala 35
40 45 Val Lys Ser Glu Thr Val Glu Pro Pro 50 55 65 57 PRT Homo
sapiens 65 Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val
Gln Ala 1 5 10 15 Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala
Ala Phe Leu Gly 20 25 30 Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile
Pro Tyr Lys Ile Glu Ala 35 40 45 Val Gln Ser Glu Thr Val Glu Pro
Pro 50 55 66 57 PRT Gallus gallus 66 Gly Ser Ile Val Tyr Leu Glu
Ile Asp Asn Arg Gln Cys Ile Gln Ser 1 5 10 15 Ser Ser Gln Cys Phe
Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly 20 25 30 Ala Leu Ala
Ser Leu Gly Asn Leu Asn Ile Pro Tyr Lys Ile Glu Ala 35 40 45 Val
Lys Ser Glu Thr Ala Glu Pro Ala 50 55 67 58 PRT Xenopus laevis 67
Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Tyr Lys Ser 1 5
10 15 Ser Ser Gln Cys Phe Asn Ser Ala Thr Asp Val Ala Ala Phe Leu
Gly 20 25 30 Ala Leu Ala Ser Leu Gly Ser Leu Asp Thr Leu Ser Tyr
Lys Ile Glu 35 40 45 Ala Val Lys Ser Glu Asn Met Glu Thr Pro 50 55
68 55 PRT Homo sapiens 68 Gly Ser Lys Val Phe Leu Glu Ile Asp Asn
Arg Gln Cys Val Gln Asp 1 5 10 15 Ser Asp His Cys Phe Lys Asn Thr
Asp Ala Ala Ala Ala Leu Leu Ala 20 25 30 Ser His Ala Ile Gln Gly
Thr Leu Ser Tyr Pro Leu Val Ser Val Val 35 40 45 Ser Glu Ser Leu
Thr Pro Glu 50 55 69 60 PRT artificial sequence consensus sequence
misc_feature (3)..(3) Xaa=Lys, Ile or Val misc_feature (5)..(5)
Xaa=Phe, Tyr or Met misc_feature (12)..(12) Xaa=Gln or Leu
misc_feature (14)..(14) Xaa=Val, Tyr, Ile, Leu or Ser misc_feature
(15)..(15) Xaa=Gln or Lys misc_feature (18)..(18) Xaa=Asp, Ser,
Ala, Glu or Gly misc_feature (19)..(19) Xaa=Ser or Asn misc_feature
(20)..(20) Xaa=Asp or Ser misc_feature (21)..(21) Xaa=His, Gln or
Asp misc_feature (24)..(24) Xaa=Lys, Asn, Pro, Gln or Arg
misc_feature (25)..(25) Xaa=Asn, Ser or Asp misc_feature (26)..(26)
Xaa=Thr or Ala misc_feature (27)..(27) Xaa=Asp, Thr or Gln
misc_feature (28)..(28) Xaa=Ala, Asp or Ser misc_feature (29)..(29)
Xaa=Ala or Val misc_feature (31)..(31) Xaa=Ala, Asp or Glu
misc_feature (32)..(32) Xaa=Leu, Phe or Tyr misc_feature (34)..(34)
Xaa=Ala or Gly misc_feature (35)..(35) Xaa=Ser or Ala misc_feature
(36)..(36) Xaa=His or Leu misc_feature (37)..(37) Xaa=Ala or Ser
misc_feature (38)..(38) Xaa=Ile, Ser or Ala misc_feature (39)..(39)
Xaa=Gln, Leu, Val or Arg misc_feature (40)..(40) Xaa=Gly or Glu
misc_feature (41)..(41) Xaa=Thr, Ser, Asn, Arg or Met misc_feature
(43)..(43) Xaa=Ser, Asp, Gln or Arg misc_feature (45)..(45)
Xaa=Leu, Ile or Phe misc_feature (46)..(46) Xaa=Ser or Pro
misc_feature (48)..(48) Xaa=Pro or Lys misc_feature (49)..(49)
Xaa=Leu or Ile misc_feature (50)..(50) Xaa=Val, Glu, Arg or Lys
misc_feature (51)..(51) Xaa=Ser, Ala, Asp or Glu misc_feature
(53)..(53) Xaa=Val, Lys, Gln, Arg or Thr misc_feature (54)..(54)
Xaa=Ser or Gly misc_feature (56)..(56) Xaa=Ser, Asn, Thr, Pro or
Lys misc_feature (57)..(57) Xaa=Leu, Met, Ala, Val or Arg
misc_feature (58)..(58) Xaa=Thr or Glu misc_feature (59)..(59)
Xaa=Pro, Thr or Ala misc_feature (60)..(60) X=Glu, Pro, Ala or Ser
69 Gly Ser Xaa Val Xaa Leu Glu Ile Asp Asn Arg Xaa Cys Xaa Xaa Ser
1 5 10 15 Ala Xaa Xaa Xaa Xaa Cys Phe Xaa Xaa Xaa Xaa Xaa Xaa Ala
Xaa Xaa 20 25 30 Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Thr
Xaa Xaa Tyr Xaa 35 40 45 Xaa Xaa Xaa Val Xaa Xaa Glu Xaa Xaa Xaa
Xaa Xaa 50 55 60 70 58 PRT Homo sapiens 70 Gly Ser Ile Val Tyr Leu
Glu Ile Asp Asn Arg Gln Cys Val Gln Ala 1 5 10 15 Ser Ser Gln Cys
Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly 20 25 30 Ala Leu
Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Pro Glu 35 40 45
Ala Val Gln Ser Glu Thr Val Glu Pro Pro 50 55 71 57 PRT Homo
sapiens 71 Gly Ser Ile Val Tyr Pro Glu Ile Asp Asn Arg Gln Cys Val
Gln Ala 1 5 10 15 Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala
Ala Phe Leu Gly 20 25 30 Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile
Pro Tyr Lys Ile Glu Ala 35 40 45 Val Gln Ser Glu Thr Val Glu Pro
Pro 50 55 72 57 PRT Homo sapiens 72 Gly Ser Ile Asp Tyr Leu Glu Ile
Asp Asn Arg Gln Cys Val Gln Ala 1 5 10 15 Ser Ser Gln Cys Phe Gln
Ser Ala Thr Asp Val Ala Ala Phe Leu Gly 20 25 30 Ala Leu Ala Ser
Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala 35 40 45 Val Gln
Ser Glu Thr Val Glu Pro Pro 50 55 73 57 PRT Homo sapiens 73 Gly Ser
Ile Val Tyr Leu Glu Asn Asp Asn Arg Gln Cys Val Gln Ala 1 5 10 15
Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly 20
25 30 Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu
Ala 35 40 45 Val Gln Ser Glu Thr Val Glu Pro Pro 50 55 74 57 PRT
Homo sapiens 74 Gly Ser Ile Val Tyr Leu Glu Thr Asp Asn Arg Gln Cys
Val Gln Ala 1 5 10 15 Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val
Ala Ala Phe Leu Gly 20 25 30 Ala Leu Ala Ser Leu Gly Ser Leu Asn
Ile Pro Tyr Lys Ile Glu Ala 35 40 45 Val Gln Ser Glu Thr Val Glu
Pro Pro 50 55 75 57 PRT Homo sapiens 75 Gly Ser Ile Val Tyr Leu Glu
Ile Asp Asn Arg Gln Cys Val Gln Ala 1 5 10 15 Ser Ser Gln Cys Phe
Gln Ser Ala Asn Asp Val Ala Ala Phe Leu Gly 20 25 30 Ala Leu Ala
Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala 35 40 45 Val
Gln Ser Glu Thr Val Glu Pro Pro 50 55 76 7671 DNA Homo sapiens 76
atgccgccgc tcctggcgcc cctgctctgc ctggcgctgc tgcccgcgct cgccgcacga
60 ggcccgcgat gctcccagcc cggtgagacc tgcctgaatg gcgggaagtg
tgaagcggcc 120 aatggcacgg aggcctgcgt ctgtggcggg gccttcgtgg
gcccgcgatg ccaggacccc 180 aacccgtgcc tcagcacccc ctgcaagaac
gccgggacat gccacgtggt ggaccgcaga 240 ggcgtggcag actatgcctg
cagctgtgcc ctgggcttct ctgggcccct ctgcctgaca 300 cccctggaca
atgcctgcct caccaacccc tgccgcaacg ggggcacctg cgacctgctc 360
acgctgacgg agtacaagtg ccgctgcccg cccggctggt cagggaaatc gtgccagcag
420 gctgacccgt gcgcctccaa cccctgcgcc aacggtggcc agtgcctgcc
cttcgaggcc 480 tcctacatct gccactgccc acccagcttc catggcccca
cctgccggca ggatgtcaac 540 gagtgtggcc agaagcccgg gctttgccgc
cacggaggca cctgccacaa cgaggtcggc 600 tcctaccgct gcgtctgccg
cgccacccac actggcccca actgcgagcg gccctacgtg 660 ccctgcagcc
cctcgccctg ccagaacggg ggcacctgcc gccccacggg cgacgtcacc 720
cacgagtgtg cctgcctgcc aggcttcacc ggccagaact gtgaggaaaa tatcgacgat
780 tgtccaggaa acaactgcaa gaacgggggt gcctgtgtgg acggcgtgaa
cacctacaac 840 tgccgctgcc cgccagagtg gacaggtcag tactgtaccg
aggatgtgga cgagtgccag 900 ctgatgccaa atgcctgcca gaacggcggg
acctgccaca acacccacgg tggctacaac 960 tgcgtgtgtg tcaacggctg
gactggtgag gactgcagcg agaacattga tgactgtgcc 1020 agcgccgcct
gcttccacgg cgccacctgc catgaccgtg tggcctcctt ctactgcgag 1080
tgtccccatg gccgcacagg tctgctgtgc cacctcaacg acgcatgcat cagcaacccc
1140 tgtaacgagg gctccaactg cgacaccaac cctgtcaatg gcaaggccat
ctgcacctgc 1200 ccctcggggt acacgggccc ggcctgcagc caggacgtgg
atgagtgctc gctgggtgcc 1260 aacccctgcg agcatgcggg caagtgcatc
aacacgctgg gctccttcga gtgccagtgt 1320 ctgcagggct acacgggccc
ccgatgcgag atcgacgtca acgagtgcgt ctcgaacccg 1380 tgccagaacg
acgccacctg cctggaccag attggggagt tccagtgcat ctgcatgccc 1440
ggctacgagg gtgtgcactg cgaggtcaac acagacgagt gtgccagcag cccctgcctg
1500 cacaatggcc gctgcctgga caagatcaat gagttccagt gcgagtgccc
cacgggcttc 1560 actgggcatc tgtgccagta cgatgtggac gagtgtgcca
gcaccccctg caagaatggt 1620 gccaagtgcc tggacggacc caacacttac
acctgtgtgt gcacggaagg gtacacgggg 1680 acgcactgcg aggtggacat
cgatgagtgc gaccccgacc cctgccacta cggctcctgc 1740 aaggacggcg
tcgccacctt cacctgcctc tgccgcccag gctacacggg ccaccactgc 1800
gagaccaaca tcaacgagtg ctccagccag ccctgccgcc acgggggcac ctgccaggac
1860 cgcgacaacg cctacctctg cttctgcctg aaggggacca caggacccaa
ctgcgagatc 1920 aacctggatg actgtgccag cagcccctgc gactcgggca
cctgtctgga caagatcgat 1980 ggctacgagt gtgcctgtga gccgggctac
acagggagca tgtgtaacat caacatcgat 2040 gagtgtgcgg gcaacccctg
ccacaacggg
ggcacctgcg aggacggcat caatggcttc 2100 acctgccgct gccccgaggg
ctaccacgac cccacctgcc tgtctgaggt caatgagtgc 2160 aacagcaacc
cctgcgtcca cggggcctgc cgggacagcc tcaacgggta caagtgcgac 2220
tgtgaccctg ggtggagtgg gaccaactgt gacatcaaca acaatgagtg tgaatccaac
2280 ccttgtgtca acggcggcac ctgcaaagac atgaccagtg gctacgtgtg
cacctgccgg 2340 gagggcttca gcggtcccaa ctgccagacc aacatcaacg
agtgtgcgtc caacccatgt 2400 ctgaaccagg gcacgtgtat tgacgacgtt
gccgggtaca agtgcaactg cctgctgccc 2460 tacacaggtg ccacgtgtga
ggtggtgctg gccccgtgtg cccccagccc ctgcagaaac 2520 ggcggggagt
gcaggcaatc cgaggactat gagagcttct cctgtgtctg ccccacgggc 2580
tggcaagcag ggcagacctg tgaggtcgac atcaacgagt gcgttctgag cccgtgccgg
2640 cacggcgcat cctgccagaa cacccacggc ggctaccgct gccactgcca
ggccggctac 2700 agtgggcgca actgcgagac cgacatcgac gactgccggc
ccaacccgtg tcacaacggg 2760 ggctcctgca cagacggcat caacacggcc
ttctgcgact gcctgcccgg cttccggggc 2820 actttctgtg aggaggacat
caacgagtgt gccagtgacc cctgccgcaa cggggccaac 2880 tgcacggact
gcgtggacag ctacacgtgc acctgccccg caggcttcag cgggatccac 2940
tgtgagaaca acacgcctga ctgcacagag agctcctgct tcaacggtgg cacctgcgtg
3000 gacggcatca actcgttcac ctgcctgtgt ccacccggct tcacgggcag
ctactgccag 3060 cacgatgtca atgagtgcga ctcacagccc tgcctgcatg
gcggcacctg tcaggacggc 3120 tgcggctcct acaggtgcac ctgcccccag
ggctacactg gccccaactg ccagaacctt 3180 gtgcactggt gtgactcctc
gccctgcaag aacggcggca aatgctggca gacccacacc 3240 cagtaccgct
gcgagtgccc cagcggctgg accggccttt actgcgacgt gcccagcgtg 3300
tcctgtgagg tggctgcgca gcgacaaggt gttgacgttg cccgcctgtg ccagcatgga
3360 gggctctgtg tggacgcggg caacacgcac cactgccgct gccaggcggg
ctacacaggc 3420 agctactgtg aggacctggt ggacgagtgc tcacccagcc
cctgccagaa cggggccacc 3480 tgcacggact acctgggcgg ctactcctgc
aagtgcgtgg ccggctacca cggggtgaac 3540 tgctctgagg agatcgacga
gtgcctctcc cacccctgcc agaacggggg cacctgcctc 3600 gacctcccca
acacctacaa gtgctcctgc ccacggggca ctcagggtgt gcactgtgag 3660
atcaacgtgg acgactgcaa tccccccgtt gaccccgtgt cccggagccc caagtgcttt
3720 aacaacggca cctgcgtgga ccaggtgggc ggctacagct gcacctgccc
gccgggcttc 3780 gtgggtgagc gctgtgaggg ggatgtcaac gagtgcctgt
ccaatccctg cgacgcccgt 3840 ggcacccaga actgcgtgca gcgcgtcaat
gacttccact gcgagtgccg tgctggtcac 3900 accgggcgcc gctgcgagtc
cgtcatcaat ggctgcaaag gcaagccctg caagaatggg 3960 ggcacctgcg
ccgtggcctc caacaccgcc cgcgggttca tctgcaagtg ccctgcgggc 4020
ttcgagggcg ccacgtgtga gaatgacgct cgtacctgcg gcagcctgcg ctgcctcaac
4080 ggcggcacat gcatctccgg cccgcgcagc cccacctgcc tgtgcctggg
ccccttcacg 4140 ggccccgaat gccagttccc ggccagcagc ccctgcctgg
gcggcaaccc ctgctacaac 4200 caggggacct gtgagcccac atccgagagc
cccttctacc gttgcctgtg ccccgccaaa 4260 ttcaacgggc tcttgtgcca
catcctggac tacagcttcg ggggtggggc cgggcgcgac 4320 atccccccgc
cgctgatcga ggaggcgtgc gagctgcccg agtgccagga ggacgcgggc 4380
aacaaggtct gcagcctgca gtgcaacaac cacgcgtgcg gctgggacgg cggtgactgc
4440 tccctcaact tcaatgaccc ctggaagaac tgcacgcagt ctctgcagtg
ctggaagtac 4500 ttcagtgacg gccactgtga cagccagtgc aactcagccg
gctgcctctt cgacggcttt 4560 gactgccagc gtgcggaagg ccagtgcaac
cccctgtacg accagtactg caaggaccac 4620 ttcagcgacg ggcactgcga
ccagggctgc aacagcgcgg agtgcgagtg ggacgggctg 4680 gactgtgcgg
agcatgtacc cgagaggctg gcggccggca cgctggtggt ggtggtgctg 4740
atgccgccgg agcagctgcg caacagctcc ttccacttcc tgcgggagct cagccgcgtg
4800 ctgcacacca acgtggtctt caagcgtgac gcacacggcc agcagatgat
cttcccctac 4860 tacggccgcg aggaggagct gcgcaagcac cccatcaagc
gtgccgccga gggctgggcc 4920 gcacctgacg ccctgctggg ccaggtgaag
gcctcgctgc tccctggtgg cagcgagggt 4980 gggcggcggc ggagggagct
ggaccccatg gacgtccgcg gctccatcgt ctacctggag 5040 attgacaacc
ggcagtgtgt gcaggcctcc tcgcagtgct tccagagtgc caccgacgtg 5100
gccgcattcc tgggagcgct cgcctcgctg ggcagcctca acatccccta caagatcgag
5160 gccgtgcaga gtgagaccgt ggagccgccc ccgccggcgc agctgcactt
catgtacgtg 5220 gcggcggccg cctttgtgct tctgttcttc gtgggctgcg
gggtgctgct gtcccgcaag 5280 cgccggcggc agcatggcca gctctggttc
cctgagggct tcaaagtgtc tgaggccagc 5340 aagaagaagc ggcgggagcc
cctcggcgag gactccgtgg gcctcaagcc cctgaagaac 5400 gcttcagacg
gtgccctcat ggacgacaac cagaatgagt ggggggacga ggacctggag 5460
accaagaagt tccggttcga ggagcccgtg gttctgcctg acctggacga ccagacagac
5520 caccggcagt ggactcagca gcacctggat gccgctgacc tgcgcatgtc
tgccatggcc 5580 cccacaccgc cccagggtga ggttgacgcc gactgcatgg
acgtcaatgt ccgcgggcct 5640 gatggcttca ccccgctcat gatcgcctcc
tgcagcgggg gcggcctgga gacgggcaac 5700 agcgaggaag aggaggacgc
gccggccgtc atctccgact tcatctacca gggcgccagc 5760 ctgcacaacc
agacagaccg cacgggcgag accgccttgc acctggccgc ccgctactca 5820
cgctctgatg ccgccaagcg cctgctggag gccagcgcag atgccaacat ccaggacaac
5880 atgggccgca ccccgctgca tgcggctgtg tctgccgacg cacaaggtgt
cttccagatc 5940 ctgatccgga accgagccac agacctggat gcccgcatgc
atgatggcac gacgccactg 6000 atcctggctg cccgcctggc cgtggagggc
atgctggagg acctcatcaa ctcacacgcc 6060 gacgtcaacg ccgtagatga
cctgggcaag tccgccctgc actgggccgc cgccgtgaac 6120 aatgtggatg
ccgcagttgt gctcctgaag aacggggcta acaaagatat gcagaacaac 6180
agggaggaga cacccctgtt tctggccgcc cgggagggca gctacgagac cgccaaggtg
6240 ctgctggacc actttgccaa ccgggacatc acggatcata tggaccgcct
gccgcgcgac 6300 atcgcacagg agcgcatgca tcacgacatc gtgaggctgc
tggacgagta caacctggtg 6360 cgcagcccgc agctgcacgg agccccgctg
gggggcacgc ccaccctgtc gcccccgctc 6420 tgctcgccca acggctacct
gggcagcctc aagcccggcg tgcagggcaa gaaggtccgc 6480 aagcccagca
gcaaaggcct ggcctgtgga agcaaggagg ccaaggacct caaggcacgg 6540
aggaagaagt cccaggacgg caagggctgc ctgctggaca gctccggcat gctctcgccc
6600 gtggactccc tggagtcacc ccatggctac ctgtcagacg tggcctcgcc
gccactgctg 6660 ccctccccgt tccagcagtc tccgtccgtg cccctcaacc
acctgcctgg gatgcccgac 6720 acccacctgg gcatcgggca cctgaacgtg
gcggccaagc ccgagatggc ggcgctgggt 6780 gggggcggcc ggctggcctt
tgagactggc ccacctcgtc tctcccacct gcctgtggcc 6840 tctggcacca
gcaccgtcct gggctccagc agcggagggg ccctgaattt cactgtgggc 6900
gggtccacca gtttgaatgg tcaatgcgag tggctgtccc ggctgcagag cggcatggtg
6960 ccgaaccaat acaaccctct gcgggggagt gtggcaccag gccccctgag
cacacaggcc 7020 ccctccctgc agcatggcat ggtaggcccg ctgcacagta
gccttgctgc cagcgccctg 7080 tcccagatga tgagctacca gggcctgccc
agcacccggc tggccaccca gcctcacctg 7140 gtgcagaccc agcaggtgca
gccacaaaac ttacagatgc agcagcagaa cctgcagcca 7200 gcaaacatcc
agcagcagca aagcctgcag ccgccaccac caccaccaca gccgcacctt 7260
ggcgtgagct cagcagccag cggccacctg ggccggagct tcctgagtgg agagccgagc
7320 caggcagacg tgcagccact gggccccagc agcctggcgg tgcacactat
tctgccccag 7380 gagagccccg ccctgcccac gtcgctgcca tcctcgctgg
tcccacccgt gaccgcagcc 7440 cagttcctga cgcccccctc gcagcacagc
tactcctcgc ctgtggacaa cacccccagc 7500 caccagctac aggtgcctga
gcaccccttc ctcaccccgt cccctgagtc ccctgaccag 7560 tggtccagct
cgtccccgca ttccaacgtc tccgactggt ccgagggcgt ctccagccct 7620
cccaccagca tgcagtccca gatcgcccgc attccggagg ccttcaagta a 7671 77 52
PRT Homo sapiens 77 Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro
Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg Glu
Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Phe Lys Arg Asp
Ala His Gly Gln Gln Met Ile Phe 35 40 45 Pro Tyr Tyr Gly 50 78 38
DNA Homo sapiens 78 tttgaattcg ggctggactg tgcggagcat gtacccga 38 79
37 DNA Homo sapiens 79 tttggatcct ccggaatgcg ggcgatctgg gactgca 37
80 20 DNA Homo sapiens 80 agccccctgt acgaccagta 20 81 18 DNA Homo
sapiens 81 cttgcgcagc tcctcctc 18 82 20 DNA Homo sapiens 82
gaccagtact gcaaggacca 20 83 18 DNA Homo sapiens 83 tcctcgcggc
cgtagtag 18 84 18 DNA Homo sapiens 84 gtgctgcaca ccaacgtg 18 85 18
DNA Homo sapiens 85 gagggcccag gagagttg 18 86 20 DNA Homo sapiens
86 gcacacggcc agcagatgat 20 87 17 DNA Homo sapiens 87 cgccgggtct
cactcac 17 88 18 DNA Homo sapiens 88 gtggcgtcat gggcctca 18 89 20
DNA Homo sapiens 89 tagcaactgg cacaaacagc 20 90 18 DNA Homo sapiens
90 catgggcctc agtgtcct 18 91 20 DNA Homo sapiens 91 gcacaaacag
ccagcgtgtc 20 92 18 DNA Homo sapiens 92 gcagcatggc atggtagg 18 93
25 DNA Homo sapiens 93 aacatgtgtt ttaaaaaggc tcctc 25 94 20 DNA
Homo sapiens 94 aaacatccag cagcagcaaa 20 95 21 DNA Homo sapiens 95
cacaggcgag gagtagctgt g 21 96 18 DNA Homo sapiens 96 gtgaccgcag
cccagttc 18 97 18 DNA Homo sapiens 97 aaaggaagcc ggggtctc 18 98 21
DNA Homo sapiens 98 agactggccc acctcgtctc t 21 99 20 DNA Homo
sapiens 99 gctctccact caggaagctc 20 100 20 DNA Homo sapiens 100
cgtctctccc acctgcctgt 20 101 18 DNA Homo sapiens 101 ctgagctcac
gccaaggt 18 102 48 PRT Homo sapiens 102 Ala Ala Gly Thr Leu Val Glu
Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe
His Phe Leu Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val
Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe 35 40 45 103 48
PRT Homo sapiens 103 Ala Ala Gly Thr Leu Val Val Glu Val Leu Met
Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg
Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Phe Lys Arg
Asp Ala His Gly Gln Gln Met Ile Phe 35 40 45 104 48 PRT Homo
sapiens 104 Ala Ala Gly Thr Leu Val Val Val Gly Leu Met Pro Pro Glu
Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser
Arg Val Leu His 20 25 30 Thr Asn Val Val Phe Lys Arg Asp Ala His
Gly Gln Gln Met Ile Phe 35 40 45 105 48 PRT Homo sapiens 105 Ala
Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Pro 1 5 10
15 Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His
20 25 30 Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met
Ile Phe 35 40 45 106 48 PRT Homo sapiens 106 Ala Ala Gly Thr Leu
Val Val Val Val Leu Met Pro Pro Glu Gln Gln 1 5 10 15 Arg Asn Ser
Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr
Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe 35 40
45 107 48 PRT Homo sapiens 107 Ala Ala Gly Thr Leu Val Val Val Val
Leu Met Pro Pro Val Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe
Leu Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Phe
Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe 35 40 45 108 48 PRT
Homo sapiens 108 Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro
Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg Glu
Pro Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Phe Lys Arg Asp
Ala His Gly Gln Gln Met Ile Phe 35 40 45 109 48 PRT Homo sapiens
109 Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu
1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg Glu His Ser Arg Val
Leu His 20 25 30 Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln
Gln Met Ile Phe 35 40 45 110 48 PRT Homo sapiens 110 Ala Ala Gly
Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg
Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ile Arg Val Leu His 20 25
30 Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe
35 40 45 111 48 PRT Homo sapiens 111 Ala Ala Gly Thr Leu Val Val
Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe
His Phe Leu Arg Glu Leu Ser Arg Val Leu His 20 25 30 Asn Asn Val
Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe 35 40 45 112 48
PRT Homo sapiens 112 Ala Ala Gly Thr Leu Val Val Val Val Leu Met
Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg
Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Glu Val Phe Lys Arg
Asp Ala His Gly Gln Gln Met Ile Phe 35 40 45 113 48 PRT Homo
sapiens 113 Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu
Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser
Arg Val Leu His 20 25 30 Thr Asn Gly Val Phe Lys Arg Asp Ala His
Gly Gln Gln Met Ile Phe 35 40 45 114 48 PRT Homo sapiens 114 Ala
Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10
15 Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His
20 25 30 Thr Asn Val Val Phe Lys Ser Asp Ala His Gly Gln Gln Met
Ile Phe 35 40 45 115 48 PRT Homo sapiens 115 Ala Ala Gly Thr Leu
Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser
Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr
Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Asn Phe 35 40
45 116 48 PRT Homo sapiens 116 Ala Ala Gly Thr Leu Val Val Val Val
Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe
Leu Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Phe
Lys Arg Asp Ala His Gly Gln Gln Met Thr Phe 35 40 45 117 48 PRT
Homo sapiens 117 Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro
Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe Arg Ser Leu Arg Glu
Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Phe Lys Arg Asp
Ala His Gly Gln Gln Met Ile Phe 35 40 45 118 47 PRT Homo sapiens
118 Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Glu Gln Leu Arg
1 5 10 15 Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu
His Thr 20 25 30 Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln
Met Ile Phe 35 40 45 119 53 PRT Homo sapiens 119 Ala Ala Gly Thr
Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn
Ser Ser Phe His Phe Ala Leu Arg Glu Leu Ser Arg Val Leu 20 25 30
His Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile 35
40 45 Phe Pro Tyr Tyr Gly 50 120 53 PRT Homo sapiens 120 Ala Ala
Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15
Arg Asn Ser Ser Phe His Leu Tyr Leu Arg Glu Leu Ser Arg Val Leu 20
25 30 His Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met
Ile 35 40 45 Phe Pro Tyr Tyr Gly 50 121 54 PRT Homo sapiens 121 Ala
Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10
15 Arg Asn Ser Ser Phe His Ser His Leu Lys Arg Glu Leu Ser Arg Val
20 25 30 Leu His Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln
Gln Met 35 40 45 Ile Phe Pro Tyr Tyr Gly 50 122 56 PRT Homo sapiens
122 Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu
1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val
Leu His 20 25 30 Thr Asn Val Leu Pro Pro Pro Ala Phe Lys Arg Asp
Ala His Gly Gln 35 40 45 Gln Met Ile Phe Pro Tyr Tyr Gly 50 55 123
54 PRT Homo sapiens 123 Ala Ala Gly Thr Leu Val Val Val Val Leu Met
Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu Arg
Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Leu Gly Arg Phe
Lys Arg Asp Ala His Gly Gln Gln Met 35 40 45 Ile Phe Pro Tyr Tyr
Gly 50
124 57 PRT Homo sapiens 124 Ala Ala Gly Thr Leu Val Val Val Val Leu
Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe His Phe Leu
Arg Glu Leu Ser Arg Val Leu His 20 25 30 Thr Asn Val Val Phe Glu
Arg Ala Arg Ser Lys Arg Asp Ala His Gly 35 40 45 Gln Gln Met Ile
Phe Pro Tyr Tyr Gly 50 55 125 53 PRT Homo sapiens 125 Ala Ala Gly
Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg
Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His 20 25
30 Thr Asn Val Val Phe His Lys Arg Asp Ala His Gly Gln Gln Met Ile
35 40 45 Phe Pro Tyr Tyr Gly 50 126 53 PRT Homo sapiens 126 Ala Ala
Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15
Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His 20
25 30 Thr Asn Val Val Phe Asp Lys Arg Asp Ala His Gly Gln Gln Met
Ile 35 40 45 Phe Pro Tyr Tyr Gly 50 127 53 PRT Homo sapiens 127 Ala
Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10
15 Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His
20 25 30 Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met
Ile Leu 35 40 45 Gly Pro Tyr Tyr Gly 50 128 57 PRT Homo sapiens 128
Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ala 1 5
10 15 Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu
Gly 20 25 30 Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys
Thr Glu Ala 35 40 45 Val Gln Ser Glu Thr Val Glu Pro Pro 50 55 129
57 PRT Homo sapiens 129 Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg
Gln Cys Val Gln Ala 1 5 10 15 Ser Ser Gln Cys Phe Gln Ser Ala Thr
Asp Val Ala Pro Phe Leu Gly 20 25 30 Ala Leu Ala Ser Leu Gly Ser
Leu Asn Ile Pro Tyr Lys Ile Glu Ala 35 40 45 Val Gln Ser Glu Thr
Val Glu Pro Pro 50 55 130 57 PRT Homo sapiens 130 Gly Ser Ile Val
Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ala 1 5 10 15 Ser Ser
Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly 20 25 30
Ala Leu Ala Ser Pro Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala 35
40 45 Val Gln Ser Glu Thr Val Glu Pro Pro 50 55 131 57 PRT Homo
sapiens 131 Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val
Gln Ala 1 5 10 15 Ser Ser Gln Cys Phe Gln Leu Ala Thr Asp Val Ala
Ala Phe Leu Gly 20 25 30 Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile
Pro Tyr Lys Ile Glu Ala 35 40 45 Val Gln Ser Glu Thr Val Glu Pro
Pro 50 55 132 60 PRT Homo sapiens 132 Gly Ser Ile Val Ser Thr Leu
Tyr Leu Glu Ile Asp Asn Arg Gln Cys 1 5 10 15 Val Gln Ala Ser Ser
Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala 20 25 30 Phe Leu Gly
Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys 35 40 45 Ile
Glu Ala Val Gln Ser Glu Thr Val Glu Pro Pro 50 55 60 133 57 PRT
Homo sapiens 133 Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln
Cys Val Gln Ala 1 5 10 15 Ser Ser Gln Cys Phe Gln Ser Ala Asn Asp
Val Ala Ala Phe Leu Gly 20 25 30 Ala Leu Ala Ser Leu Gly Ser Leu
Asn Ile Pro Tyr Lys Ile Glu Ala 35 40 45 Val Gln Ser Glu Thr Val
Glu Pro Pro 50 55 134 57 PRT Homo sapiens 134 Gly Ser Ile Val Tyr
Leu Glu Asn Asp Asn Arg Gln Cys Val Gln Ala 1 5 10 15 Ser Ser Gln
Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly 20 25 30 Ala
Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala 35 40
45 Val Gln Ser Glu Thr Val Glu Pro Pro 50 55 135 57 PRT Homo
sapiens 135 Gly Ser Ile Asp Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val
Gln Ala 1 5 10 15 Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala
Ala Phe Leu Gly 20 25 30 Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile
Pro Tyr Lys Ile Glu Ala 35 40 45 Val Gln Ser Glu Thr Val Glu Pro
Pro 50 55 136 57 PRT Homo sapiens 136 Gly Ser Ile Val Tyr Pro Glu
Ile Asp Asn Arg Gln Cys Val Gln Ala 1 5 10 15 Ser Ser Gln Cys Phe
Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly 20 25 30 Ala Leu Ala
Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala 35 40 45 Val
Gln Ser Glu Thr Val Glu Pro Pro 50 55 137 70 PRT Homo sapiens 137
Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ala 1 5
10 15 Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu
Gly 20 25 30 Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys
Ile Glu Arg 35 40 45 Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu
Ala Val Val Gln Ser 50 55 60 Glu Thr Val Glu Pro Pro 65 70 138 81
PRT Homo sapiens 138 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro
Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro
Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly
Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met
Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln
Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu
139 168 PRT Homo sapiens 139 Trp Leu Ser Arg Leu Gln Ser Gly Met
Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro
Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met
Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser
Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala
Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70
75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln
Gln 85 90 95 Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His
Leu Gly Val 100 105 110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser
Phe Leu Ser Gly Glu 115 120 125 Pro Ser Gln Ala Asp Val Gln Pro Leu
Gly Pro Ser Ser Leu Ala Val 130 135 140 His Thr Ile Leu Pro Gln Glu
Ser Pro Ala Leu Pro Thr Ser Leu Pro 145 150 155 160 Ser Leu Ile Leu
Trp Ser His Pro 165 140 134 PRT Homo sapiens 140 Trp Leu Ser Arg
Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg
Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30
Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35
40 45 Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg
Leu 50 55 60 Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln
Pro Gln Asn 65 70 75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala
Asn Ile Gln Gln Gln 85 90 95 Gln Ser Leu Gln Pro Pro Pro Pro Pro
Pro Gln Pro His Leu Gly Val 100 105 110 Ser Ser Ala Ala Ser Gly His
Leu Gly Arg Ser Phe Leu Ser Gly Glu 115 120 125 Pro Ser Gln Ala Val
Leu 130 141 116 PRT Homo sapiens 141 Trp Leu Ser Arg Leu Gln Ser
Gly Met Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val
Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His
Gly Met Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala
Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55
60 Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn
65 70 75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln
Gln Gln 85 90 95 Gln Ser Leu Cys Gly Leu Ser Pro Arg Arg Pro His
His His His Ser 100 105 110 Arg Thr Leu Ala 115 142 99 PRT Homo
sapiens 142 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr
Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr
Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro Leu His
Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met Ser Tyr
Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro His Leu
Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln Met Gln
Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95 Gln Ser
Leu 143 174 PRT Homo sapiens 143 Trp Leu Ser Arg Leu Gln Ser Gly
Met Val Pro Asn Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala
Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly
Met Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu
Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60
Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65
70 75 80 Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln
Gln Gln 85 90 95 Gln Ser Leu Gln Gln Pro His Leu Gly Val Ser Ser
Ala Ala Ser Gly 100 105 110 His Leu Gly Arg Ser Phe Leu Ser Gly Glu
Pro Ser Gln Ala Asp Val 115 120 125 Gln Pro Leu Gly Pro Ser Ser Leu
Ala Val His Thr Ile Leu Pro Gln 130 135 140 Glu Ser Pro Ala Leu Pro
Thr Ser Leu Pro Ser Ser Leu Val Pro Pro 145 150 155 160 Val Thr Ala
Ala Gln Phe Leu Thr Pro Pro Ser Gln His Ser 165 170 144 297 PRT
Homo sapiens 144 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn
Gln Tyr Asn Pro 1 5 10 15 Leu Arg Gly Ser Val Ala Pro Gly Pro Leu
Ser Thr Gln Ala Pro Ser 20 25 30 Leu Gln His Gly Met Val Gly Pro
Leu His Ser Ser Leu Ala Ala Ser 35 40 45 Ala Leu Ser Gln Met Met
Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu 50 55 60 Ala Thr Gln Pro
His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn 65 70 75 80 Leu Gln
Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln 85 90 95
Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val 100
105 110 Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu Ser Gly
Glu 115 120 125 Pro Ser Gln Ala Asp Val Gln Pro Leu Gly Pro Ser Ser
Leu Ala Val 130 135 140 His Thr Ile Leu Pro Gln Glu Ser Pro Ala Leu
Pro Thr Ser Leu Pro 145 150 155 160 Ser Ser Leu Val Pro Pro Val Thr
Ala Ala Gln Phe Leu Thr Pro Pro 165 170 175 Ser Gln His Ser Tyr Ser
Ser Pro Val Asp Asn Thr Pro Ser His Gln 180 185 190 Leu Gln Val Pro
Glu His Pro Phe Leu Thr Pro Ser Pro Glu Ser Pro 195 200 205 Asp Gln
Trp Ser Ser Ser Ser Pro His Pro Ala Phe Gln Arg Leu Arg 210 215 220
Leu Val Arg Gly Arg Leu Gln Pro Ser His Gln His Ala Val Pro Asp 225
230 235 240 Arg Pro His Ser Gly Gly Leu Gln Val Asn Gly Ala Pro His
Glu Thr 245 250 255 Pro Ala Ser Phe Pro Lys Pro Ser Gly Val Cys Val
Arg Ser Val Asp 260 265 270 Ala Arg Ala Asp Gln Arg Ser Leu Phe Lys
Thr His Val Phe Ile Gln 275 280 285 Asn Lys Asn Glu Asp Phe Asn Phe
Phe 290 295 145 49 PRT Homo sapiens 145 Ala Ala Gly Thr Leu Val Val
Val Val Leu Met Pro Pro Glu Gln Leu 1 5 10 15 Arg Asn Ser Ser Phe
His Phe Leu Ser Arg Glu Leu Ser Arg Val Leu 20 25 30 His Thr Asn
Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile 35 40 45 Phe
146 42 DNA Homo sapiens 146 cccggttggg cagcctcaac atcccctaca
agatcgaggc cg 42 147 12 DNA Homo sapiens 147 atcaatgccc cc 12 148
17 DNA Homo sapiens 148 gagcacacag gccccct 17 149 14 DNA Homo
sapiens 149 ttaagtagag actt 14 150 12 DNA Homo sapiens 150
gggccgtgga cg 12 151 15 DNA Homo sapiens 151 gtggaggggg gatgg 15
152 10 DNA Homo sapiens 152 gtcccctgac 10 153 10 DNA Homo sapiens
153 tcctcacccc 10 154 9 PRT Homo sapiens 154 Gly Cys His Pro Arg
Trp Ser His Pro 1 5 155 13 PRT Homo sapiens 155 Pro Cys Pro Arg Arg
Cys His Pro Arg Trp Ser His Pro 1 5 10 156 37 PRT Homo sapiens 156
Leu Ser Arg Asp Leu Cys Ser His Trp Ala Pro Ala Ala Trp Arg Cys 1 5
10 15 Thr Leu Phe Cys Pro Arg Arg Ala Pro Pro Cys Pro Arg Arg Cys
His 20 25 30 Pro Arg Trp Ser His 35 157 34 PRT Homo sapiens 157 Cys
Cys Ser His Trp Ala Pro Ala Ala Trp Arg Cys Thr Leu Phe Cys 1 5 10
15 Pro Arg Arg Ala Pro Pro Cys Pro Arg Arg Cys His Pro Arg Trp Ser
20 25 30 His Pro 158 38 PRT Homo sapiens 158 Glu Gly Arg Gly Arg
Cys Ser His Trp Ala Pro Ala Ala Trp Arg Cys 1 5 10 15 Thr Leu Phe
Cys Pro Arg Arg Ala Pro Pro Cys Pro Arg Arg Cys His 20 25 30 Pro
Arg Trp Ser His Pro 35 159 38 PRT Homo sapiens 159 Gly Gly Gly Gly
Met Gly Ser His Trp Ala Pro Ala Ala Trp Arg Cys 1 5 10 15 Thr Leu
Phe Cys Pro Arg Arg Ala Pro Pro Cys Pro Arg Arg Cys His 20 25 30
Pro Arg Trp Ser His Pro 35 160 39 PRT Homo sapiens 160 Glu Arg Ala
Arg Gln Thr Cys Ser His Trp Ala Pro Ala Ala Trp Arg 1 5 10 15 Cys
Thr Leu Phe Cys Pro Arg Arg Ala Pro Pro Cys Pro Arg Arg Cys 20 25
30 His Pro Arg Trp Ser His Pro 35 161 40 PRT Homo sapiens 161 Arg
Val Arg Ala Arg Gln Thr Cys Ser His Trp Ala Pro Ala Ala Trp 1 5 10
15 Arg Cys Thr Leu Phe Cys Pro Arg Arg Ala Pro Pro Cys Pro Arg Arg
20 25 30 Cys His Pro Arg Trp Ser His Pro 35 40 162 12 PRT Homo
sapiens 162 Arg His His His His His Ser Arg Thr Leu Val Ala 1 5 10
163 70 PRT Homo sapiens 163 Asp Ser Gly Pro Ala Arg Pro Arg Ile Pro
Thr Ser Pro Thr Gly Pro 1 5 10 15 Arg Ala Ser Pro Ala Leu Pro Pro
Ala Cys Ser Pro Arg Ser Pro Ala 20 25 30 Phe Arg Arg Pro Ser Ser
Lys Arg Arg Ala Pro Arg Asp Pro Gly Phe 35 40 45 Leu Ser Gln Ala
Phe Gly Arg Leu Cys Ala Leu Cys Gly Cys Gln Gly 50 55 60 Arg
Pro
Glu Glu Pro Ser 65 70 164 12 PRT Homo sapiens 164 Gly Arg Gln His
Pro Gln Pro Pro Ala Thr Gly Ala 1 5 10
uspto.report is an independent third-party trademark research tool that is not affiliated, endorsed, or sponsored by the United States Patent and Trademark Office (USPTO) or any other governmental organization. The information provided by uspto.report is based on publicly available data at the time of writing and is intended for informational purposes only.
While we strive to provide accurate and up-to-date information, we do not guarantee the accuracy, completeness, reliability, or suitability of the information displayed on this site. The use of this site is at your own risk. Any reliance you place on such information is therefore strictly at your own risk.
All official trademark data, including owner information, should be verified by visiting the official USPTO website at www.uspto.gov. This site is not intended to replace professional legal advice and should not be used as a substitute for consulting with a legal professional who is knowledgeable about trademark law.