Tyrosine kinome

Abstract

Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in -20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention.

Description

[0002] A portion of the disclosure of this patent document contains material which is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent file or records, but otherwise reserves all copyright rights whatsoever.

FIELD OF THE INVENTION

[0003] The invention relates to the field of cancer genetics and therapeutics. In particular, it relates to genetic changes that affect protein kinase gene families or other gene families. These genetic changes are useful in diagnostic, prognostic, drug discovery, and clinical drug testing applications.

BACKGROUND OF THE INVENTION

[0004] Tyrosine kinases (TKs) are central regulators of signaling pathways that control differentiation, transcription, cell cycle progression, apoptosis, motility, and invasion (1). Although genetic alterations in a few TK genes have been linked to human cancer (2), most TK genes have not been directly implicated in tumorigenesis. Additionally, it is not known how many or how often members of the TK gene family are altered in any particular cancer type.

BRIEF SUMMARY OF THE INVENTION

[0005] In a first embodiment of the invention a method is provided for detecting mutations involved in cancer. Members of a family of genes in a database of human nucleotide sequences are identified based on homology to a known member of the family. Nucleotide sequence differences in a selected region of each of the members of the family of genes are identified in matched pairs of an individual's cancer cells and normal cells. Such differences identify members of heightened interest Additional nucleotide sequence differences in the members of heightened interest are determined, either in one or more additional regions outside of the selected region, or in matched pairs of cancer cells and normal cells of additional individuals, or in both.

[0006] Another embodiment of the invention provides a method of screening test substances for use as anti-cancer agents. A test substance is contacted with an activated protein kinase selected from the group consisting of: NTRK3, FES, MCCK/MLK4, EPHA3, NTRK2, INSRR, JAK1, PDGFRA, EPHA7, EPHA8, KDR, FGFR1, and ERBB4. Activity of the activated protein kinase is assayed. A test substance which inhibits the activity of the activated protein kinase is a potential anti-cancer agent.

[0007] Another embodiment of the invention provides a method of screening test substances for use as anti-cancer agents. A test substance is contacted with a mutated GUCY2F guanylate cyclase. Activity of the mutated GUCY2F guanylate cyclase is assayed. A test substance which increases the activity of the mutated GUCY2F guanylate cyclase is a potential anti-cancer agent.

[0008] Another embodiment of the invention provides an isolated, activated protein kinase. The kinase is selected from the group consisting of: NTRK3, FES, MCCK/MLK4, GUCY2F, EPHA3, NTRK2, INSRR, JAK1, PDGFRA, EPHA7, EPHA8, KDR, FGFR1, and ERBB4.

[0009] Another embodiment of the invention provides an isolated, mutated GUCY2F protein.

[0010] Still another embodiment of the invention is a method of categorizing cancers. The sequence of one or more protein kinase family members in a sample of a cancer tissue is determined. The one or more members is selected from the group consisting of NTRK3, FES, MCCK/MLK4, EPHA3, NTRK2, INSRR, JAK1, PDGFRA, EPHA7, EPHA8, GUCY2F, KDR, FGFR1, and ERBB4. A somatic mutation of said one or more protein kinase family members is identified in the cancer tissue. The cancer tissue is assigned to a group based on the presence of the somatic mutation.

BRIEF DESCRIPTION OF THE DRAWINGS

[0011] FIG. 1 shows detection of mutations in tyrosine kinase genes. Representative examples of mutations in NTRK3 (FIG. 1A) and MCCK/MLK4 (FIG. 1B) identified using the Mutation Explorer software package (SoftGenetics, State College, PA). In each case, the top box contains the sequence chromatogram from tumor DNA, the middle box contains the sequence chromatogram from normal tissue from the same patient, and the lower box contains a computed comparison between the tumor and normal traces displaying a peak at the observed alteration.

[0012] FIG. 2 shows distribution of mutations in NTRK3, FES, MCCK/MLK4 and GUCY2F. Arrows indicate location of mutations while boxes represent functional domains.

[0013] FIG. 3 shows sequence conservation and location of mutations in altered genes. Alignment of amino acid sequences for (FIG. 3A) NTRK3, (FIG. 3B) FES, NTRK2 and EPHA3, and (FIG. 3C) MCCK/MLK4. Conserved residues are indicated by a dot, while nonconserved residues are indicated by a letter. The positions of identified mutations in each gene are highlighted in yellow, while positions of mutations in MET and BRAF are highlighted in blue. Underlined regions represent the activation loop (subdomain VII and VIII).

DETAILED DESCRIPTION OF THE INVENTION

[0014] Any database can be used in the present invention, whether public, subscription, or proprietary to identify members of a family of genes. Databases can be of nucleotide sequences or protein sequences. They can be of genomic sequences or expressed sequence tags or cDNA sequences. Preferably the sequences are human sequences although the same methods can be used for other species. Homology to a known member may be based on limited portions of the known member, such as a catalytic domain or a regulatory domain. Alternatively homology may be based on the whole protein. Any algorithm or program known in the art can be used. Suitable programs are available publicly and commercially, or they can be made by the individual worker in the art.

[0015] Nucleotide sequence differences in a family member can be determined between a sample of cancer cells and normal cells. Cancer and normal cells typically are matched pairs, i.e., they are derived from the same individual and optionally from the same organ. Any technique can be used to determine nucleotide sequence differences. Sequencing of genomic DNA or cDNA can be used. Other techniques which detect differences between two sequences can also be used, without limitation. Techniques which detect differences between the encoded proteins can also be used, since a change in the amino acid of a protein indicates that the nucleotide sequence has been changed.

[0016] Selected regions of the family members can be initially screened for nucleotide differences. Any basis for selecting a region can be used. Regions can be selected based on knowledge of mutations in similar regions of other proteins, or based on predictions of particularly important domains of the encoded proteins. Examples of important domains include, but are not limited to catalytic domains and regulatory domains.

[0017] One method for determining the functional significance of any mutation which is found is to determine the effect that the mutation has on the encoded protein. A synonymous mutation creates no change in the encoded protein and is sometimes termed silent. Such a mutation is less likely to be functionally relevant to cancer than a non-synonymous mutation. One can determine an encoded protein by identifying an mRNA transcribed from a gene containing a mutation and translating the mRNA (or derived cDNA).

[0018] Another method for determining functional significance of a mutation is to determine if the mutation affects an evolutionarily conserved amino acid residue. This can be done by aligning sequences of the same protein from different species and assessing which ones are invariant or predominantly so. The mutation is then compared with this determination of evolutionarily conserved residues to identify if the mutation affects such a residue.

[0019] Another method for attributing functional significance to a mutation is to determine if it affects an important domain of the protein. Such domains include but are not limited to catalytic domains and regulatory domains. Another index of functional significance of a new mutation can be found by comparing the amino acid residue affected by the new mutation with equivalent residues in other proteins. If mutations have been found affecting the equivalent residues and those mutations have been determined to be associated with disease, then the new mutation is more likely to be functionally significant. The equivalent mutation may be in the positionally equivalent amino acid residue, or in a close neighbor, perhaps within 5, within 3, within 2, or within 1 residue of the positionally equivalent amino acid residue.

[0020] The identified protein kinase family members which have been found to harbor cancer-associated mutations can be used to screen test substances for use as anti-cancer agents. The encoded mutant proteins can be isolated from cells and used in vitro in a cell-free assay. Alternatively, cancer cell lines harboring the mutant protein kinase family members can be used. Cells which have been genetically modified to express the encoded mutant protein can also be used. Regardless of the form in which the mutant protein is presented, it can be contacted with a test substance and the affect on enzymatic activity assessed. If the mutant protein is an activated protein kinase, then test substances will desirably inhibit the activity. If the mutant protein is enzymatically less active than its wild-type cognate, then the test substance will desirably restore activity. Although the family members were selected as being homologous to a tyrosine kinase, all family members are not tyrosine kinases. Some phosphorylate other residues of proteins, such as serine and/or threonine. Others contain inactive kinase domains and have other catalytic domains, such as guanylate cyclase activity. Assays for tyrosine, serine, or threonine kinase activity are well known in the art. See, e.g., the HitHunter.TM. Enzyme Fragment Complementation Assay of Applied Biosystems, Foster City, Calif., Tyrosine Kinase Assay Kits, (Green or Red) of Panvera, Madison Wis. Any such assay can be used. Assays for guanylate cyclase are also well known. One commercially availably assay kit which may be used is a cGMP RIA assay (Amersham, Bucks., UK).

[0021] An isolated protein, whether an activated protein kinase or a mutant guanylate cyclase can be obtained from cancer cells which express such proteins. Alternatively, they can be obtained from cells which have been genetically modified to express such cancer-specific forms of the protein. Any means for isolating the enzymes from the cells can be used to form a cell-free preparation. Further purification of the enzymes can be used as desired. Any purification methods known in the art can be used without limitation, including immunoaffinity methods and chromatography methods.

[0022] Mutations in the kinase family members taught herein can be used to categorize cancers. Such mutations can be identified in cancer tissue and not in corresponding non-cancer tissue of an individual. This pattern indicates that the mutations are somatic mutations. The cancers can be categorized based on the kinase family member which is mutated, based on the particular mutation in the kinase family member, or based on the residue mutated within the family member. Such categorization can be correlated with mortality data to enable prognosis on the basis of the category. Such categorization can be correlated with recurrence data to enable prognosis on the basis of the category. Such categorization can be correlated with efficacy of a therapeutic agent to enable prescription of drugs for individuals with higher probability of successful treatment. Patients can be assigned to clinical trials on the basis of the categorization of their cancers. Correlations of the categories of cancers are not limited by this list.

EXAMPLES

Example 1

Identification of Genes Encoding a Protein Family

[0023] Using a combination of hidden Markov models and global homology searches similar to those recently described (3), we identified 98 genes encoding proteins that contained tyrosine kinase domains in the Celera (Rockville, Md.) and public genome databases (4). Seven of these represented previously uncharacterized genes that were identified solely on the basis of sequence similarity to other human tyrosine kinase genes.

Example 2

Initial Screen for Mutations in Catalytic Domain

[0024] As an initial screen to evaluate whether these genes were genetically altered in colorectal cancer, we analyzed all exons encoding the predicted kinase domain. This region has been found to harbor the great majority of previously observed tyrosine kinase gene alterations in other cancers (2, 5). A total of 589 exons containing this domain were extracted from genomic databases (6). To identify coding changes in these genes, the identified exons were amplified using polymerase chain reaction on template DNA derived from 35 colorectal cancers and directly sequenced (7). Six of the selected cancer cell lines had deficiencies in mismatch repair (MMR). Inclusion of these cancers allowed identification of genes that might be preferentially implicated in different forms of sporadic colorectal cancer, as was observed with the BRAF kinase (8, 9).

[0025] A total of 249 alterations not present in the normal human genome sequence were identified in the cancers. Of these 249, 15 alterations proved to be somatic, while the others were found to be present in normal cells of the same patients. The 15 alterations affected 13 different genes (examples in FIG. 1). One MMR-deficient and one MMR proficient tumor were observed to have mutations in the TGF-.beta. receptor Type II (TGFBR2) gene. These comprised two different transitions affecting the same codon, C to T change at nucleotide position 1582 resulting in a R528C substitution, and G to A at 1583 resulting in a R528H substitution. As the prevalence of mutations in the kinase domain of TGFBR2 is known to be quite rare (10, 11), these data indicated that our methods were sufficiently sensitive to detect mutations even when present at low frequencies.

Example 3

Expanded Screen for Mutations in Other Cancers and/or Domains

[0026] The 12 remaining mutant genes were further analyzed for mutations in another 155 colorectal cancers. Two or more additional mutations were found in only four of the genes, and all coding exons of these four genes were then analyzed in all 190 cancers (12). We thereby identified a total of 42 non-synonymous mutations (Table 1). There were six mutations in the neurotrophic receptor NTRK3, four in the feline sarcoma oncogene (FES), ten in the guanylate cyclase 2F gene (GUCY2F), and ten in a predicted tyrosine kinase like gene with no known fuiction, hereafter called MCCK/MLK4. Two additional genes, EPHA3 and NTRK2, had two alterations each (Table 1). Seven of ten mutations in GUCY2F, which is on the X chromosome, were homozygous, while 29 of the 34 alterations in the remaining genes were heterozygous. All of these mutations were shown to be somatic in the cancers that could be assessed; in three of the 42 cases, no normal tissue was available for comparison. TABLE-US-00001 TABLE 1 Mutations observed in the tyrosine kinome Celera Genbank Number of Amino Residue Gene Accession Accession Mutations* Nucleotide acid.sup.+ Properties.sup..dagger-dbl. NTRK3 hCT17758 NM_002530 6 A2083G I695V C, K, M G1822A G608S K, M C2278A L760I C, K A2195C K732T K G2192A R731Q K G2192A R731Q K FES hCT23770 NM_002005 4 A2110G M704V C, K, M G2117A R706Q C, K, M G2227A V743M C, K C2283T S759F C, K MCCK/MLK4 hCT6856 NM_032435 10 C781T H261Y C, K C783G H261Q C, K G872A G291E C, K, M C878A A293E C, K, M G888A W296STP K C1408T R470C C C1408T R470C C C1657T R553Stp C A1787T N596I C A1885G K629E GUCY2F hCT11696 NM_001522 10 G673T D225Y G1078A A360T C A1083T Q361H C1170A F390L C G1475A R492H C A1635T R545S K A1872T E624D C, K A2333G E778G K +2T > C Splice site* G3226A V1026M C TGFBR2 hCT17988 NM_003242 2 C1582T R528C C, K G1583A R528H C, K EPHA3 hCT23516 NM_005233 2 T2374C S792P K G2416A D806N C, K NTRK2 hCT18879 NM_006180 2 C2084T T695I C, K G2251A D751N C, K INSRR hCT31077 XM_043563 1 C2863T T985M C, K JAK1 hCT13272 NM_002227 1 A2656A E886K K PDGFRA hCT13252 NM_006206 1 +1G > A Splice site* K EPHA7 hCT23587 NM_004440 1 G2303T S768I K EPHA8 hCT31226 NM_020526 1 G2617A D873N C, K ERBB4 hCT6470 NM 005235 1 C3090G I1030M K *Number of mutations observed in panel of 190 colorectal cancers. For TGFBR2 only the initial panel of 36 tumors was analyzed for mutations. .sup.+Amino acid change resulting from mutation. Splice site alterations affected position 2 of the donor splice site of exon 17 of GUCY2F, and position 1 of the donor site of exon 15 of PDGFRA. .sup..dagger-dbl.C, residue is evolutionarily conserved, K, residue is within kinase domain, M, mutation of equivalent residue in other kinases is disease causing.

Example 4

Evidence of Functional Relevance of Mutations

[0027] One of the most difficult issues confronting the sequence analysis of cancer genomes is the distinction between functionally relevant and "passenger" mutations. Each of the clonal expansions driving the neoplastic process leads to fixation of any mutation that had previously occurred in the clone's progenitor cell, whether or not the mutation was responsible for the clonal expansion. Several observations support the hypothesis that the six genes mutated more than once among the tumors in our cohort (NTRK3, FES, MCCK/MLK4, GUCY2F, EPHA3, NTRK2) were functional rather than coincidental.

[0028] The first observation involved comparison of synonymous vs. non-synonymous alterations identified during sequencing. Synonymous mutations are likely to be passengers, as they would not be expected to exert a selective growth advantage. Only one somatic synonymous mutation was identified in these six genes, yielding a N:S (non-synonymous:synonymous) ratio of 34:1, far higher than the N:S ratio of 2:1 predicted for non-functional mutations (p<1.times.10.sup.-4).

[0029] Second, most of the non-synonymous mutations identified in these genes occurred in conserved residues in key regions in the kinase domain (Table 1, examples in FIG. 2). All mutated residues in FES, two of six mutated residues in NTRK3, eight of ten mutated residues in MCCK/MLK4, five of ten mutated residues in GUCY2F, both mutated residues in NTRK2, and one of two mutated residues in EPHA3 were identical in all species analyzed. Based on comparisons to related tyrosine kinase genes (13, 14), these alterations were predicted to affect residues in functionally important regions of the kinase domain. In NTRK3, three alterations were located in two subdomains predicted to affect kinase activity: the I695V alteration was localized in subdomain VII, while the cluster of R732Q and K733T mutations was directly adjacent to subdomain Vm. These subdomains comprise the activation loop, normally responsible for autoinhibition of tyrosine kinase activity (13, 14). An additional substitution in FES (R706Q), two alterations in MCCK/MLK4 (G291E, A293E), and an alteration in EPHA3 (S792P) also occurred in the activation loop. Mutations in the activation loop have been shown to lead to ligand-independent tyrosine kinase activation in other genes by relief of the autoinhibitory function of these domains (2). Identical alterations at equivalent residues in NTRK2 (D751N) and EPHA3 (D806N), as well as an alteration in FES (V743M) were in subdomain IX, a region known to stabilize the catalytic loop. Finally, two substitutions in MCCK/MLK4 at position 261 were located in subdomain VIB, the catalytic loop of the kinase domain, but did not affect the invariant aspartate and asparagine residues required for phosphoryl transfer.

[0030] Many of the mutations we detected corresponded to those previously shown to be functionally mutated in other protein kinase genes (15) (Table 1, examples in FIG. 3). In NTRK3, the I695V mutation corresponded to a homologous position in the MET oncogene that is altered in renal cell carcinoma (5), while G608S represented an equivalent residue that is affected in the RET oncogene in Hirschsprung's disease (16). Two mutations in FES, M704V and R706Q, and two mutations in MCCK/MLK4 corresponded to or were just adjacent to residues that are altered in the BRAF oncogene in a variety of cancers (6), and are in a region surrounded by three previously reported mutations in MET in renal cell carcinoma (5). Additionally, one mutation in EPHA3 (S792P) was just adjacent to a previously reported alteration in MET in renal cell and hepatocellular carcinomas (5). No mutations in GUCY2F corresponded to alterations in other protein kinase genes, but two alterations (E596K and V1026M) were located near equivalent mutations of the homologous GUCY2D gene that is inactivated in Leber's congenital amaurosis (17).

[0031] It was of interest to compare the non-synonymous alterations in these six genes with the three synonymous mutations that were discovered in the study (one in the six genes noted above and two others identified during the sequencing of other tyrosine kinase genes). None of the 3 synonymous mutations occurred in residues that had previously been shown to be functionally altered in other cancers or inherited conditions. Moreover, the prevalence of these synonymous mutations, calculated to be 1.1 alterations per Mb (95% confidence interval 0.23 to 3.3 alterations per Mb) was consistent with previous estimates of the prevalence of nonfunctional alterations in tumor DNA (18). In contrast, the prevalence of non-synonymous alterations in the kinase domain of the six analyzed genes was estimated to be significantly higher at 55 alterations per Mb (95% confidence interval 33 to 85 alterations per Mb; p<0.001). We conclude that the three synonymous mutations observed were likely to be passengers while the 34 non-synonymous mutations identified among six genes were likely to be functional.

[0032] Based on their positions and analogous mutations in homologous genes, the majority of alterations we observed are expected to act in a dominant fashion, leading to increased kinase activity. In this respect, the observation of nonsense alterations in MCCK/MLK4 is not unprecedented. Truncations in Src and Met resulting in constitutively active kinase activity have been previously reported (19, 20). Interestingly, MCCK/MLK4 contains an SH3 domain whose homolog has been shown to autoinhibit kinase activity (21). Such kinase autoinhibition would be relieved by the nonsense codons between the kinase and SH3-binding domains at the C-terminus that we observed in two cancers.

Example 5

Significance

[0033] This study represents the first systematic mutational analysis of any gene family in a human cancer. Despite decades of research on tyrosine kinase genes, only a few of the genes we had found mutated had been previously linked to tumorigenesis. A fusion gene of NTRK3 with ETV6 has been identified in congenital fibrosarcoma (22), and neurotrophin ligands, including those for NTRK2 and NTRK3, appear to stimulate the invasive behavior of at least several cancer types (23, 24). The v-fes transforming oncogene was identified as a causative agent of feline and avian sarcomas (25), but its human equivalent (FES) has not been found to be altered in any human neoplasia. A homolog of MCCK/MLK4, MLK3, as well as a homolog of EPHA3, EPHA1, have transforming abilities in NIH3T3 cells (26, 27), but their roles in tumorigenesis are otherwise unknown. GUCY2F has only been known to function in light-mediated signal transduction in photoreceptor cells of the retina (28), and had not been thought to play a role in any tissue outside the eye. Using quantitative PCR, we found that all four commonly mutated genes, including GUCY2F, were expressed in both primary cancers as well as cell lines derived from the colon (29).

[0034] One reason for attempting to identify tyrosine kinase mutations is that the altered proteins provide attractive targets for therapeutic intervention. This has been convincingly demonstrated with STI571 in patients with chronic myelogenous leukemia (30). The number of colorectal cancer patients with mutations in the six tyrosine kinase genes noted above outnumbers the number of patients with CML or with any cancer type previously associated with tyrosine kinase mutations. These results thereby provide substantial new opportunities for drug development. Moreover, future investigation of the pathways through which these kinases act in colorectal cancer may yield new insights into pathogenesis as well as additional drug targets. Personalized therapeutics can be based on the kinases that are mutationally activated in an individual's cancer. Finally, the large scale sequencing-based approach we used to find novel gene mutations can readily be applied to other enzyme-encoding genes in any common tumor type.

[0035] While the invention has been described with respect to specific examples including presently preferred modes of carrying out the invention, those skilled in the art will appreciate that there are numerous variations and permutations of the above described systems and techniques that fall within the spirit and scope of the invention as set forth in the appended claims.

References and Notes

[0036] 1. T. Hunter, Philos Trans R Soc Lond B Biol Sci 353, 583-605. (1998). [0037] 2. P. Blume-Jensen, T. Hunter, Nature 411, 355-65. (2001). [0038] 3. G. Manning, D. B. Whyte, R. Martinez, T. Hunter, S. Sudarsanam, Science 298, 1912-34. (2002). [0039] 4. All annotated genes present in the draft human genome sequence (CHGD Assembly 25H, Jun. 19, 2001) were initially analyzed using both hidden Markov models and global homology searches using the Panther protein classification system (world wide web domain name: celera.com) to identify protein families of receptor and non-receptor tyrosine kinases. To eliminate potential artifactual clustering of related proteins lacking a kinase domain in these families, all identified proteins were further analyzed by blast analysis against the catalytic domain of the SRC protooncogene. From this analysis, only those proteins showing similarities with an E score of<1.times.10.sup.-14 were retained. All identified tyrosine kinase genes are available in Supplemental Table 1. [0040] 5. A. Danilkovitch-Miagkova, B. Zbar, J Clin Invest 109, 863-7. (2002). [0041] 6. Sequences for all available annotated exons and adjacent intronic sequences of identified TK genes were extracted from Celera draft human genome sequence (CHGD Assembly 25H, Jun. 19, 2001) or from Genbank (world wide web domain name: genbank.nlm.nih.gov). All exons encoding the catalytic domain of each kinase were identified by pairwise homology analyses to canonical tyrosine kinase catalytic domains. [0042] 7. Primers for PCR amplification and sequencing were designed using the Primer 3 program (world wide web domain name: www-genome.wi.mit.edu/cgi-bin/primer/primer3_www.cgi), and were synthesized by MWG (High Point, N.C.) and IDT (Coralville, Iowa). PCR amplification and sequencing were performed on tumor DNA from early passage cell lines as previously described(18) using 384 capillary automated sequencing apparatuses (Spectrumedix, State College, PA). Of the 589 exons extracted, 556 (94%) were successfully analyzed, each in an average of 33 tumor samples. Sequence traces were assembled and analyzed to identify potential genomic alterations using Mutation Explorer software package (SoftGenetics, State College, PA). Sequences of all primers used for PCR amplification and sequencing are available in Supplemental Table 2. [0043] 8. H. Davies et al., Nature (Jun. 9, 2002). [0044] 9. H. Rajagopalan et al., Nature 418, 934. (2002). [0045] 10. W. M. Grady et al., Cancer Res 59, 320-4 (1999). [0046] 11. S. J. Kim, Y. H. Im, S. D. Markowitz, Y. J. Bang, Cytokine Growth Factor Rev 11, 159-68. (2000). [0047] 12. All available annotated exons and adjacent intronic regions were extracted for NTRK3, FES, GUCY2F and MCCK from the Celera draft human genome sequence (CHGD Assembly 25H, Jun. 19, 2001). Tumor DNA from 142 MMR proficient and 48 MMR deficient early--passage colorectal cancer cell lines passaged in vitro or as xenografts in nude mice were analyzed for each exon. [0048] 13. S. K. Hanks, T. Hunter, Faseb J 9, 576-96. (1995). [0049] 14. S. R. Hubbard, J. H. Till, Annu Rev Biochem 69, 373-98. (2000). [0050] 15. Altered tyrosine kinase genes identified were aligned to other protein kinase genes using CLUSTAL and identified alterations were compared to previously observed mutations reported in the literature or at the Human Gene Mutation Database at Cardiff University (world wide web domain name: archive.uwcm.ac.uk/uwcm/mg/hgmd0.html). [0051] 16. M. Sancandi et al., J Pediatr Surg 35, 139-42; discussion 142-3. (2000). [0052] 17. I. Perrault et al., Eur J Hum Genet 8, 578-82. (2000). [0053] 18. T. L. Wang et al., Proc Natl Acad Sci USA 99, 3076-80. (2002). [0054] 19. R. B. Irby et al., Nat Genet 21, 187-90. (1999). [0055] 20. V. Wallenius et al., Am J Pathol 156, 821-9. (2000). [0056] 21. H. Zhang, K. A. Gallo, J Biol Chem 276, 45598-603. (2001). [0057] 22. S. R. Knezevich, D. E. McFadden, W. Tao, J. F. Lim, P. H. Sorensen, Nat Genet 18, 184-7. (1998). [0058] 23. S. J. Miknyoczki et al., Int J Cancer 81, 417-27. (1999). [0059] 24. D. Marchetti, D. J. McQuillan, W. C. Spohn, D. D. Carson, G. L. Nicolson, Cancer Res 56, 2856-63. (1996). [0060] 25. B. Scheijen, J. D. Griffin, Oncogene 21, 3314-33. (2002). [0061] 26. J. Hartkamp, J. Troppmair, U. R. Rapp, Cancer Res 59, 2195-202. (1999). [0062] 27. M. Nakamoto, A. D. Bergemann, Microsc Res Tech 59, 58-67. (2002). [0063] 28. K. A. Lucas et al., Pharmacol Rev 52, 375-414. (2000). [0064] 29. Total RNA was isolated from two primary colorectal cancers and two colorectal cancer cell lines using RNAgents (Promega, Madison, Wis.) and mRNA was selected using the MessageMaker Reagent Assembly (Gibco BRL). Single-stranded cDNA was generated using Superscript II Reverse Transcriptase (Gibco BRL) following the manufacturer's directions. Mock template preparations were prepared in parallel without the addition of reverse transcriptase. Quantitative PCR was performed with an iCycler (Bio-Rad, Hercules, Calif.) using SYBR Green dye (Molecular Probes, Eugene, Oreg.), as previously described (31). [0065] 30. B. J. Druker, Cancer Cell 1, 31-6. (2002). [0066] 31. S. Saha et al., Science 294, 1343-6 (Nov. 9, 2001).

Sequence CWU 1

1

2191 1 52 PRT Homo sapiens 1 Cys Leu Val Gly Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met 1 5 10 15 Ser Arg Asp Val Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly His Thr 20 25 30 Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Met Tyr Arg Lys 35 40 45 Phe Thr Thr Glu 50 2 52 PRT Drosophila melanogaster 2 Cys Leu Val Asn Glu Gly Leu Val Val Lys Ile Ser Asp Phe Gly Leu 1 5 10 15 Ser Arg Asp Ile Tyr Ser Ser Asp Tyr Tyr Arg Val Gln Ser Lys Ser 20 25 30 Leu Leu Pro Val Arg Trp Met Pro Ser Glu Ser Ile Leu Tyr Gly Lys 35 40 45 Phe Thr Thr Glu 50 3 52 PRT Caenorhabditis elegans 3 Cys Leu Val Gly Asp Thr Arg Thr Ile Lys Ile Ala Asp Phe Gly Leu 1 5 10 15 Met Arg Thr Ser Tyr Gly Ser Asp Tyr Tyr Lys Met Leu His Arg Ser 20 25 30 Trp Met Pro Val Arg Trp Met Ser Lys Glu Ala Ile Glu Gln Gly Arg 35 40 45 Phe Ser Glu Ala 50 4 54 PRT Homo sapiens 4 Cys Met Leu Asp Glu Lys Phe Thr Val Lys Val Ala Asp Phe Gly Leu 1 5 10 15 Ala Arg Asp Met Tyr Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr 20 25 30 Gly Ala Lys Leu Pro Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr 35 40 45 Gln Lys Phe Thr Thr Lys 50 5 55 PRT Homo sapiens 5 Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile Gly Asp Phe Gly Leu 1 5 10 15 Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His Gln Phe Glu Gln Leu 20 25 30 Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val Ile Arg Met Gln Asp 35 40 45 Lys Asn Pro Tyr Ser Phe Gln 50 55 6 66 PRT Homo sapiens 6 Lys Asn Val Leu Lys Ile Ser Asp Phe Gly Met Ser Arg Glu Glu Ala 1 5 10 15 Asp Gly Val Tyr Ala Ala Ser Gly Gly Leu Arg Gln Val Pro Val Lys 20 25 30 Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg Tyr Ser Ser Glu Ser 35 40 45 Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Thr Phe Ser Leu Gly 50 55 60 Ala Ser 65 7 66 PRT Felis domesticus 7 Lys Asn Val Leu Lys Ile Ser Asp Phe Gly Met Ser Arg Glu Glu Ala 1 5 10 15 Asp Gly Ile Tyr Ala Ala Ser Gly Gly Leu Arg Gln Val Pro Val Lys 20 25 30 Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg Tyr Ser Ser Glu Ser 35 40 45 Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Thr Phe Ser Leu Gly 50 55 60 Ala Ser 65 8 66 PRT Mus musculus 8 Lys Asn Val Leu Lys Ile Ser Asp Phe Gly Met Ser Arg Glu Glu Ala 1 5 10 15 Asp Gly Ile Tyr Ala Ala Ser Ala Gly Leu Arg Gln Val Pro Val Lys 20 25 30 Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg Tyr Ser Ser Glu Ser 35 40 45 Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Thr Phe Ser Leu Gly 50 55 60 Ala Ser 65 9 65 PRT Rattus norvegicus 9 Asn Asn Thr Leu Lys Ile Ser Asp Phe Gly Met Ser Arg Gln Glu Asp 1 5 10 15 Gly Gly Val Tyr Ser Ser Ser Gly Leu Lys Gln Ile Pro Ile Lys Trp 20 25 30 Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg Tyr Ser Ser Glu Ser Asp 35 40 45 Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Thr Phe Ser Leu Gly Val 50 55 60 Cys 65 10 66 PRT Gallus domesticus 10 Lys Asn Thr Leu Lys Ile Ser Asp Phe Gly Met Ser Arg Gln Glu Glu 1 5 10 15 Asp Gly Val Tyr Ala Ser Thr Gly Gly Met Lys Gln Ile Pro Val Lys 20 25 30 Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg Tyr Ser Ser Glu Ser 35 40 45 Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ala Phe Ser Leu Gly 50 55 60 Val Val 65 11 64 PRT Drosophila melanogaster 11 Glu His Ser Val Lys Ile Ser Asp Phe Gly Met Ser Arg Glu Glu Glu 1 5 10 15 Glu Tyr Ile Val Ser Asp Gly Met Lys Gln Ile Pro Val Lys Trp Thr 20 25 30 Ala Pro Glu Ala Leu Asn Phe Gly Lys Tyr Thr Ser Leu Cys Asp Val 35 40 45 Trp Ser Tyr Gly Ile Leu Met Trp Glu Ile Phe Ser Lys Gly Asp Thr 50 55 60 12 66 PRT Homo sapiens 12 Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr 1 5 10 15 Ser Thr Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg 20 25 30 Trp Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser 35 40 45 Asp Val Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly 50 55 60 Lys Gln 65 13 67 PRT Homo sapiens 13 Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu 1 5 10 15 Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly Lys Ile Pro Ile 20 25 30 Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr Ser Ala 35 40 45 Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu Val Met Ser Tyr 50 55 60 Gly Glu Arg 65 14 68 PRT Homo sapiens 14 Lys Phe Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr 1 5 10 15 Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro 20 25 30 Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr 35 40 45 Lys Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Leu Met Thr 50 55 60 Arg Gly Ala Pro 65 15 68 PRT Homo sapiens 15 Asp Leu Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser 1 5 10 15 Arg Trp Ser Gly Ser His Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu 20 25 30 Trp Met Ala Pro Glu Val Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser 35 40 45 Phe Gln Ser Asp Val Tyr Ala Phe Gly Ile Val Leu Tyr Glu Leu Met 50 55 60 Thr Gly Gln Leu 65 16 63 PRT Homo sapiens 16 Phe Val Pro Ile Leu His Arg Asp Leu Lys Ser Ser Asn Ile Leu Leu 1 5 10 15 Leu Glu Lys Ile Glu His Asp Asp Ile Cys Asn Lys Thr Leu Lys Ile 20 25 30 Thr Asp Phe Gly Leu Ala Arg Glu Trp His Arg Thr Thr Lys Met Ser 35 40 45 Thr Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val Ile Lys Ser 50 55 60 17 63 PRT Mus musculus 17 Val Val Pro Ile Leu His Arg Asp Leu Lys Ser Ser Asn Ile Leu Leu 1 5 10 15 Leu Glu Lys Ile Glu His Asp Asp Ile Cys Asn Lys Thr Leu Lys Ile 20 25 30 Thr Asp Phe Gly Leu Ala Arg Glu Trp His Arg Thr Thr Arg Met Ser 35 40 45 Ala Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val Ile Arg Ser 50 55 60 18 63 PRT Anopholes funestus 18 Pro Ile Ser Val Ile His Arg Asp Leu Lys Ser Ser Asn Val Leu Ile 1 5 10 15 Ser Glu Ser Ile Gln His Gly His Leu Leu Asn Lys Thr Leu Lys Ile 20 25 30 Thr Asp Phe Gly Leu Ala Arg Glu Ala Tyr Arg Thr Thr Arg Met Ser 35 40 45 Ala Ala Gly Thr Phe Ala Trp Met Pro Pro Glu Val Ile Arg Ser 50 55 60 19 63 PRT Drosophila melanogaster 19 Pro Met Ser Ile Ile His Arg Asp Leu Lys Ser Ser Asn Val Leu Ile 1 5 10 15 Tyr Glu Ala Ile Glu Gly Asn His Leu Gln Gln Lys Thr Leu Lys Ile 20 25 30 Thr Asp Phe Gly Leu Ala Arg Glu Met Tyr Asn Thr Gln Arg Met Ser 35 40 45 Ala Ala Gly Thr Tyr Ala Trp Met Pro Pro Glu Val Ile Ser Val 50 55 60 20 61 PRT Homo sapiens 20 Ser Lys Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu 1 5 10 15 Asp Glu Lys Phe Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp 20 25 30 Met Tyr Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys 35 40 45 Leu Pro Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr 50 55 60 21 57 PRT Homo sapiens 21 Ser Ile Ile His Arg Asp Leu Lys Ser Asn Asn Ile Phe Leu His Glu 1 5 10 15 Asp Leu Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser 20 25 30 Arg Trp Ser Gly Ser His Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu 35 40 45 Trp Met Ala Pro Glu Val Ile Arg Met 50 55 22 10 DNA Homo sapiens 22 cggargttca 10 23 10 DNA Homo sapiens 23 cggaagttca 10 24 10 DNA Homo sapiens 24 tgcascggga 10 25 10 DNA Homo sapiens 25 tgcaccggga 10 26 18 DNA Homo sapiens 26 atggagggct tcctggag 18 27 18 DNA Homo sapiens 27 gccatcggca ttgacaag 18 28 20 DNA Homo sapiens 28 tcgggaaaca caaaaacatc 20 29 21 DNA Homo sapiens 29 gagtacttgg cctcccagaa g 21 30 20 DNA Homo sapiens 30 acgtgcacaa cctcgactac 20 31 20 DNA Homo sapiens 31 tcctgggtgt ggtttctacc 20 32 19 DNA Homo sapiens 32 acgacctgtg agtggcatc 19 33 19 DNA Homo sapiens 33 gacgtgagtg ctggctctg 19 34 22 DNA Homo sapiens 34 aaatcttcat tcaatgctgg tg 22 35 20 DNA Homo sapiens 35 ggccttttca tttcccatac 20 36 23 DNA Homo sapiens 36 tttctttatg attctgcaca tgg 23 37 19 DNA Homo sapiens 37 attcaggttg cctgccttg 19 38 20 DNA Homo sapiens 38 tgaaaagggc aggcatttag 20 39 21 DNA Homo sapiens 39 ttgaaccatt tgaaccattc c 21 40 20 DNA Homo sapiens 40 ttgtgtttaa ggctgcatgg 20 41 26 DNA Homo sapiens 41 ttctaagtct gtaccagcat aatgtc 26 42 20 DNA Homo sapiens 42 gccgatatgg agaagtacgg 20 43 23 DNA Homo sapiens 43 ttcatatgtc aagaccgtac agc 23 44 20 DNA Homo sapiens 44 gttgcatgga ggattttgtg 20 45 20 DNA Homo sapiens 45 tcattcctag ctccccacag 20 46 20 DNA Homo sapiens 46 agcgactttg gtcagaaagg 20 47 23 DNA Homo sapiens 47 ttgcgttaaa atgaacaagt gtc 23 48 20 DNA Homo sapiens 48 tggctcatgt gaaggagttg 20 49 24 DNA Homo sapiens 49 caattgttcc atttaaaacc ttcc 24 50 21 DNA Homo sapiens 50 aatacacctg ccttgttgtg c 21 51 20 DNA Homo sapiens 51 aggctggtct caaactcctg 20 52 20 DNA Homo sapiens 52 cactgagctc atcaccaagg 20 53 21 DNA Homo sapiens 53 ggtgtaccag ccccatttta c 21 54 20 DNA Homo sapiens 54 gtagggctag gagcggtagg 20 55 20 DNA Homo sapiens 55 cctcacttgg ggcctagttc 20 56 19 DNA Homo sapiens 56 aggacgcctg ggagatcag 19 57 18 DNA Homo sapiens 57 ggacgcctgg gagatcag 18 58 20 DNA Homo sapiens 58 acgagacaag tgaggggttg 20 59 20 DNA Homo sapiens 59 tctttctggg cctcagtctc 20 60 21 DNA Homo sapiens 60 aatagctcct tgatgctgtg c 21 61 20 DNA Homo sapiens 61 gggttcatgg aggtcttctg 20 62 20 DNA Homo sapiens 62 accaatgaat cccgtttctg 20 63 22 DNA Homo sapiens 63 gagatttagg gtgggaaaga gg 22 64 20 DNA Homo sapiens 64 tgggaaggtg tctgtagtcg 20 65 22 DNA Homo sapiens 65 ttgaggagga gagacttttg ag 22 66 23 DNA Homo sapiens 66 tgggcaaaat ataaaaagca cag 23 67 20 DNA Homo sapiens 67 taatcgacag ggcatgctac 20 68 20 DNA Homo sapiens 68 cctgggtgct acaggacaag 20 69 20 DNA Homo sapiens 69 gagcgagact ccatctcagg 20 70 22 DNA Homo sapiens 70 tcaagattga agaggtgatt gg 22 71 20 DNA Homo sapiens 71 ctatgatggc accactgcac 20 72 20 DNA Homo sapiens 72 ttggagagta ggaggcttgg 20 73 20 DNA Homo sapiens 73 gggcaaacag agttggagag 20 74 19 DNA Homo sapiens 74 agcttcaact ccggctagg 19 75 20 DNA Homo sapiens 75 cagaagtgtc cgttcattgg 20 76 20 DNA Homo sapiens 76 ccgggaactg ttgacatctg 20 77 20 DNA Homo sapiens 77 cttgtgtcct ctccctccac 20 78 22 DNA Homo sapiens 78 aaggcagtag tctgtggagg ac 22 79 22 DNA Homo sapiens 79 cgagggatct gaaaactgac tc 22 80 27 DNA Homo sapiens 80 aattccttag aagaatagat tcagacc 27 81 20 DNA Homo sapiens 81 aggccaccta aggagagagc 20 82 20 DNA Homo sapiens 82 tcagggtgac agtgaggatg 20 83 21 DNA Homo sapiens 83 ttcctgaccg attgtaagca c 21 84 20 DNA Homo sapiens 84 tccctctctg cctttctcac 20 85 23 DNA Homo sapiens 85 tcacagagct atatgatggc aac 23 86 20 DNA Homo sapiens 86 aacctctctc aggacgttgc 20 87 20 DNA Homo sapiens 87 ccccgtaggg aggaagactc 20 88 20 DNA Homo sapiens 88 gaaaccttct ggctgattgg 20 89 21 DNA Homo sapiens 89 aaagttgagc aatttgcaag c 21 90 20 DNA Homo sapiens 90 tcaggatggg ggaaagaaac 20 91 20 DNA Homo sapiens 91 aagcaggagg gctatgttcc 20 92 20 DNA Homo sapiens 92 tgattcgctg ttttcaaagg 20 93 20 DNA Homo sapiens 93 ctaccaaccc tggctactgc 20 94 19 DNA Homo sapiens 94 tgggtgcata cagccaatc 19 95 20 DNA Homo sapiens 95 gcatacctca gcctcagctc 20 96 20 DNA Homo sapiens 96 ttgggggaga gactcagatg 20 97 22 DNA Homo sapiens 97 ttcctctggg tcttcatagc tc 22 98 20 DNA Homo sapiens 98 agaaaatgga caggctggtg 20 99 22 DNA Homo sapiens 99 caacaagaca gactgtgctg ag 22 100 20 DNA Homo sapiens 100 gggttgcttc cttcttttcc 20 101 23 DNA Homo sapiens 101 tcaatctcat gtttacaggg ttc 23 102 19 DNA Homo sapiens 102 gtggagggtg ggagagaag

19 103 21 DNA Homo sapiens 103 ttggagatca tcatgggagt c 21 104 20 DNA Homo sapiens 104 acctcacact ggtgctcctc 20 105 20 DNA Homo sapiens 105 gggatgagga gaggaaatgg 20 106 19 DNA Homo sapiens 106 ccaaagcagg gatcagagc 19 107 20 DNA Homo sapiens 107 cttccttccc agccattttc 20 108 21 DNA Homo sapiens 108 gcttctgctt ctgtgaaatg g 21 109 21 DNA Homo sapiens 109 tgcttctgct tctgtgaaat g 21 110 19 DNA Homo sapiens 110 ctcatggctg ttggattgc 19 111 19 DNA Homo sapiens 111 ctggagcttg gggctagag 19 112 20 DNA Homo sapiens 112 tcagtgatgt ggctcagctc 20 113 19 DNA Homo sapiens 113 agacaccgac ctgatgcac 19 114 20 DNA Homo sapiens 114 ccctcccatc ccctagtatc 20 115 20 DNA Homo sapiens 115 gagtcacctt gggaaacagg 20 116 18 DNA Homo sapiens 116 gtcccaggaa gggcactc 18 117 20 DNA Homo sapiens 117 gaggtggagg ttgcaatgag 20 118 24 DNA Homo sapiens 118 tgaatccagc agtttaaatg tttc 24 119 25 DNA Homo sapiens 119 ctgaatccag cagtttaaat gtttc 25 120 23 DNA Homo sapiens 120 tatcatataa tctgctcgca ttg 23 121 23 DNA Homo sapiens 121 tgctgctttg gtagataatt tgc 23 122 20 DNA Homo sapiens 122 tgatccttct ttcccctgtg 20 123 22 DNA Homo sapiens 123 tgttcaaggg attagaacat gg 22 124 21 DNA Homo sapiens 124 ttcccacaag cacagtatga g 21 125 24 DNA Homo sapiens 125 aagcattttc atagattgat gtgc 24 126 20 DNA Homo sapiens 126 tgccgttctg attctgtctg 20 127 18 DNA Homo sapiens 127 cgcttttcgg ctgcttag 18 128 20 DNA Homo sapiens 128 tcctgccctt atggaatttg 20 129 20 DNA Homo sapiens 129 atggcagcta aatgctggag 20 130 21 DNA Homo sapiens 130 gcttgactcc agagattttg c 21 131 19 DNA Homo sapiens 131 ctttccccac cattcaagg 19 132 20 DNA Homo sapiens 132 ttcccaggtg aacaaagagc 20 133 26 DNA Homo sapiens 133 gccactctta aataagaaat caaagc 26 134 20 DNA Homo sapiens 134 cagcctcaag gacaagaagc 20 135 23 DNA Homo sapiens 135 tctacgatct gtttccagct ttc 23 136 20 DNA Homo sapiens 136 ccaggagttg gaaaacgaag 20 137 26 DNA Homo sapiens 137 aaaaatccct ttaaaacatc agatac 26 138 21 DNA Homo sapiens 138 tgttcagcac atgtaatcca g 21 139 22 DNA Homo sapiens 139 ttcagcacat gtaatccaga ac 22 140 20 DNA Homo sapiens 140 tgccgtttgc cttttatgag 20 141 21 DNA Homo sapiens 141 tggagggcag tacaaaagtt c 21 142 21 DNA Homo sapiens 142 gacggagtct cactctgttg c 21 143 20 DNA Homo sapiens 143 aggctgaggg ctatcagttg 20 144 19 DNA Homo sapiens 144 agatcacgcc actgcactc 19 145 21 DNA Homo sapiens 145 cgctgtccac taaggtagct c 21 146 24 DNA Homo sapiens 146 ttcaatcatg gaacttttat cagc 24 147 20 DNA Homo sapiens 147 gttggggttg atttcattgc 20 148 20 DNA Homo sapiens 148 tggcaaaacc aggacctatc 20 149 20 DNA Homo sapiens 149 ttacccaccc agatgaggag 20 150 20 DNA Homo sapiens 150 tagaggtccc cagacagcag 20 151 20 DNA Homo sapiens 151 gagacccact gttgaacctg 20 152 20 DNA Homo sapiens 152 ggcagatccc ttctttggag 20 153 20 DNA Homo sapiens 153 agaggacaga cccacgtttg 20 154 19 DNA Homo sapiens 154 cacacagcct ggtcctgag 19 155 20 DNA Homo sapiens 155 ggcacagaga aggagctcag 20 156 20 DNA Homo sapiens 156 cacgatgact tggaggagtc 20 157 18 DNA Homo sapiens 157 aagggcaccc tgggtaag 18 158 20 DNA Homo sapiens 158 aaggccagcc ctttatatcc 20 159 20 DNA Homo sapiens 159 gtgccaggga ctgagagttc 20 160 20 DNA Homo sapiens 160 tgaccacgct accagtgaag 20 161 23 DNA Homo sapiens 161 caactaagtc ccacatcttc cag 23 162 20 DNA Homo sapiens 162 ggcagaatct tgccatactg 20 163 21 DNA Homo sapiens 163 tttcctcaaa ttggtccagt c 21 164 20 DNA Homo sapiens 164 tgatctgcct gcaagttcac 20 165 22 DNA Homo sapiens 165 catcattcaa ggcgtacttt tg 22 166 21 DNA Homo sapiens 166 aggtgattgg gatcatctga g 21 167 20 DNA Homo sapiens 167 ggatttttct ttgggagctg 20 168 26 DNA Homo sapiens 168 tctcttgtca ccaaaaatac agaaag 26 169 20 DNA Homo sapiens 169 ttttggccac aaagttcttg 20 170 20 DNA Homo sapiens 170 ctttcgggaa ggttgttgag 20 171 24 DNA Homo sapiens 171 ttgggactaa gtagtctgat ccac 24 172 20 DNA Homo sapiens 172 gatctgaaac gggactttgc 20 173 20 DNA Homo sapiens 173 ggtgtgggtt acaggcattc 20 174 21 DNA Homo sapiens 174 ttttgctcaa cagatcagtg c 21 175 25 DNA Homo sapiens 175 tgtcagttga actaagctca ttttg 25 176 26 DNA Homo sapiens 176 cagttgaact aagctcattt tgaatc 26 177 20 DNA Homo sapiens 177 gggatggcag accttaaatc 20 178 20 DNA Homo sapiens 178 ctctgggcct tgtctgtttc 20 179 18 DNA Homo sapiens 179 accagcaggg aagctgtg 18 180 23 DNA Homo sapiens 180 cctttcttct cacagtggat ttg 23 181 20 DNA Homo sapiens 181 caaagctgtc ttgcctgaag 20 182 20 DNA Homo sapiens 182 gttgaacttg gcctttccag 20 183 20 DNA Homo sapiens 183 acacagatga ttggcagcag 20 184 20 DNA Homo sapiens 184 atgtttgggc acactgcttg 20 185 20 DNA Homo sapiens 185 ttgcaagaat aaggcagcag 20 186 20 DNA Homo sapiens 186 tccgagccat catgagagac 20 187 19 DNA Homo sapiens 187 aaggccagac agcgagaac 19 188 20 DNA Homo sapiens 188 cctgtaatga aggggcgaag 20 189 26 DNA Homo sapiens 189 aatattcttg cataaaagtc agaacc 26 190 20 DNA Homo sapiens 190 ggtcagatgt gcaccatagc 20 191 25 DNA Homo sapiens 191 cattgaaagc taataaggat tttgg 25 192 23 DNA Homo sapiens 192 agagttgtat cccattttct gtg 23 193 21 DNA Homo sapiens 193 ggcagcatac acacatcctt c 21 194 22 DNA Homo sapiens 194 acacacacac agacacacac ac 22 195 19 DNA Homo sapiens 195 actgccacta cccccaaac 19 196 20 DNA Homo sapiens 196 gggttgggtt gaattgtcag 20 197 20 DNA Homo sapiens 197 cttctggact gggatgaagg 20 198 20 DNA Homo sapiens 198 acttgtgatg ctcccagagg 20 199 20 DNA Homo sapiens 199 tgctgaggct ccctataacc 20 200 20 DNA Homo sapiens 200 agatgacagc cggttctctg 20 201 20 DNA Homo sapiens 201 tctttgcagg cctctctgtc 20 202 20 DNA Homo sapiens 202 ctgtgtccac ccccttactc 20 203 19 DNA Homo sapiens 203 cacaccctga ctccaccac 19 204 20 DNA Homo sapiens 204 gttctgtgcc caggagtgtc 20 205 20 DNA Homo sapiens 205 ggctgacatc tgtgagcatc 20 206 20 DNA Homo sapiens 206 tggagttgga gacagagcac 20 207 20 DNA Homo sapiens 207 tggagaggtc aggagattgg 20 208 19 DNA Homo sapiens 208 ccctccatct gggtctctg 19 209 20 DNA Homo sapiens 209 ccctgatgct ctcctttgtc 20 210 20 DNA Homo sapiens 210 ccaccacatg agtagcttgc 20 211 20 DNA Homo sapiens 211 gccaggaggg taggagtatg 20 212 21 DNA Homo sapiens 212 tgtgaagaag acgatggtga g 21 213 20 DNA Homo sapiens 213 tcggggagag gaggtttatg 20 214 20 DNA Homo sapiens 214 ggccaaggcc agatacttac 20 215 20 DNA Homo sapiens 215 tcagctggtc ctttggagtc 20 216 20 DNA Homo sapiens 216 aagtgtgagt caccccatcc 20 217 23 DNA Homo sapiens 217 aaaaatgcta aattccacaa tgc 23 218 23 DNA Homo sapiens 218 cctggtggag gtagaggaaa tag 23 219 20 DNA Homo sapiens 219 gcggccaatt gtgtctaatc 20 220 20 DNA Homo sapiens 220 actgccccct gttgtcatag 20 221 27 DNA Homo sapiens 221 tccaatgata agactaattt ggatagg 27 222 26 DNA Homo sapiens 222 ccaatgataa gactaatttg gatagg 26 223 20 DNA Homo sapiens 223 ctccatcctg ggtgacagag 20 224 21 DNA Homo sapiens 224 ttggtgtcag gcgaattaaa g 21 225 20 DNA Homo sapiens 225 ctttccctct ctgcctctcc 20 226 19 DNA Homo sapiens 226 tttccctctc tgcctctcc 19 227 20 DNA Homo sapiens 227 agaccaagtc acctctgtgc 20 228 20 DNA Homo sapiens 228 cagaggtggc tgcctaaatc 20 229 19 DNA Homo sapiens 229 cccttcgcac agcttatgg 19 230 20 DNA Homo sapiens 230 aaaaggtgcg aggaatcaag 20 231 20 DNA Homo sapiens 231 acagtctcac agccatcgtg 20 232 20 DNA Homo sapiens 232 actgaggaag caccaacagc 20 233 20 DNA Homo sapiens 233 gacactcaga aacccccaac 20 234 20 DNA Homo sapiens 234 gtctgtgtgt cctgcacagc 20 235 20 DNA Homo sapiens 235 ggcctgcagt tccaattttc 20 236 20 DNA Homo sapiens 236 ggtcagacag tggggtcatc 20 237 20 DNA Homo sapiens 237 gagggaggtg ttagcagtgg 20 238 20 DNA Homo sapiens 238 tccacacagc tctgaccatc 20 239 18 DNA Homo sapiens 239 gggtggggtg agtgtgtg 18 240 21 DNA Homo sapiens 240 aggtcatcaa gtcaggtgag g 21 241 20 DNA Homo sapiens 241 ctgtctcact tggggcttcc 20 242 19 DNA Homo sapiens 242 ctgcaaggtg gctgacttc 19 243 18 DNA Homo sapiens 243 gctctgccca ggagtcac 18 244 20 DNA Homo sapiens 244 aggtggccgt gaagaatatc 20 245 19 DNA Homo sapiens 245 caccaggggc tgtacattg 19 246 20 DNA Homo sapiens 246 tccatcaagg ggaaactgag 20 247 20 DNA Homo sapiens 247 tgggggagga ctcaattagg 20 248 20 DNA Homo sapiens 248 ctgctctggg aggtcttctc 20 249 20 DNA Homo sapiens 249 ggctgtgttt caaggtctgg 20 250 20 DNA Homo sapiens 250 gagtcctgcc aacacctgac 20 251 22 DNA Homo sapiens 251 caggatatga tgaacagcca ag 22 252 19 DNA Homo sapiens 252 aggctgaggc aggagaatg 19 253 19 DNA Homo sapiens 253 aaagaggctg aggcaggag 19 254 20 DNA Homo sapiens 254 ctgggtaaca gagcgagacc 20 255 21 DNA Homo sapiens 255 gagaacgtgg tggtaagaag g 21 256 22 DNA Homo sapiens 256 cgcatcttga tgagtgctct ac 22 257 22 DNA Homo sapiens 257 cgcatcttga tgagtgctct ac 22 258 20 DNA Homo sapiens 258 tgatactggg cgaaagaagc 20 259 20 DNA Homo sapiens 259 acgacatgca ctcaatagcc 20 260 18 DNA Homo sapiens 260 gtagcccccg aaggtgag 18 261 19 DNA Homo sapiens 261 ggagtggttg gtgatggtg 19 262 20 DNA Homo sapiens 262 acattctgga aggggaccac 20 263 20 DNA Homo sapiens 263 ttgcccttcc ctcactaaac 20 264 20 DNA Homo sapiens 264 ttgtcgtgaa ggtgctgaag 20 265 20 DNA Homo sapiens 265 tgccgtatgg atccctctac 20 266 20 DNA Homo sapiens 266 ctgtcattgg gctaccttcc 20 267 20 DNA Homo sapiens 267 ttgcccagca tgttattgag 20 268 25 DNA Homo sapiens 268 tcaatcaaat actgtcactg ctctc 25 269 23 DNA Homo sapiens 269 tgtgtgataa gcaatgggta ctg 23 270 20 DNA Homo sapiens 270 catgaaatcc cagacaatgg 20 271 25 DNA Homo sapiens 271 tgggactaaa attaaaatct gatgg 25 272 24 DNA Homo sapiens 272 caaggccact tataagctat cacc 24 273 20 DNA Homo sapiens 273 gctctgcagc actctcactg 20 274 20 DNA Homo sapiens 274 ttgtccgcac tgagttgaag 20 275 20 DNA Homo sapiens 275 catccatcct gtgtcactcg 20 276 20 DNA Homo sapiens 276 cacacctgtt ccacctctcc 20 277 19 DNA Homo sapiens 277 gccctggaca agttccttc 19 278 20 DNA Homo sapiens 278 gtgtcctctc acctgcacac 20 279 20 DNA Homo sapiens 279 gcccttcctg tctgtttctg 20 280 20 DNA Homo sapiens 280 gttgcccaga taaggagacg 20 281 19 DNA Homo sapiens 281 tctccaccct cctcctctg 19

282 20 DNA Homo sapiens 282 tccaggacta acggtgcttc 20 283 20 DNA Homo sapiens 283 gggtgtcttt ggaactgtgc 20 284 20 DNA Homo sapiens 284 cagggtcctg tgcttctcag 20 285 21 DNA Homo sapiens 285 tgtcttccac aaaaccagtc c 21 286 19 DNA Homo sapiens 286 agatcgcacc actgcactc 19 287 18 DNA Homo sapiens 287 ccagtctggg cgacagag 18 288 21 DNA Homo sapiens 288 ccttttgaga ccccctctta g 21 289 20 DNA Homo sapiens 289 ctcctgacct caggtgatcc 20 290 20 DNA Homo sapiens 290 gagacccacc acggtatctg 20 291 20 DNA Homo sapiens 291 ggaattcacg agatggaagc 20 292 20 DNA Homo sapiens 292 tgtttggaga aaatcggaag 20 293 20 DNA Homo sapiens 293 aagtgcacca agaaccgact 20 294 18 DNA Homo sapiens 294 tgatgaacgc cctggttc 18 295 19 DNA Homo sapiens 295 ccaggctggt cagagtcac 19 296 20 DNA Homo sapiens 296 gattagggag cttggtgctg 20 297 20 DNA Homo sapiens 297 aggggtccct cacttttctc 20 298 20 DNA Homo sapiens 298 tcccagatgt gaagctggag 20 299 20 DNA Homo sapiens 299 tccttgggtg tgtgtgtctg 20 300 20 DNA Homo sapiens 300 tcttcctggt ttgaggttgg 20 301 20 DNA Homo sapiens 301 cagtgtctgg ccctattgtg 20 302 21 DNA Homo sapiens 302 ggaggggatt tacatgtacg c 21 303 20 DNA Homo sapiens 303 tgagagggaa gtgacccttg 20 304 20 DNA Homo sapiens 304 gggagaggag ttggaaaagg 20 305 19 DNA Homo sapiens 305 agcggaggag agtggagag 19 306 20 DNA Homo sapiens 306 ggcaggtcag agtggaggag 20 307 21 DNA Homo sapiens 307 caccagaaac ccaaacaact g 21 308 19 DNA Homo sapiens 308 ttgcctttgc ctgctgtag 19 309 20 DNA Homo sapiens 309 tgctggagaa ggaaggagtc 20 310 20 DNA Homo sapiens 310 ataagccata ggcaggatgg 20 311 21 DNA Homo sapiens 311 cagcatcttc acacacctct g 21 312 20 DNA Homo sapiens 312 gcctagcctt tagcttgtgc 20 313 23 DNA Homo sapiens 313 tgcctttctt cagattcatt ctc 23 314 20 DNA Homo sapiens 314 gaaccagctg ccgttgttag 20 315 20 DNA Homo sapiens 315 gtgccaacaa catcaaccac 20 316 22 DNA Homo sapiens 316 cctttctgtg catttctcat tc 22 317 20 DNA Homo sapiens 317 ttctctagcc cttccccaac 20 318 20 DNA Homo sapiens 318 aaatgcacag gcacttttgg 20 319 20 DNA Homo sapiens 319 accagggagc aactgaactg 20 320 22 DNA Homo sapiens 320 tgagtaacag ggcaaacaga ag 22 321 23 DNA Homo sapiens 321 atgagtaaca gggcaaacag aag 23 322 20 DNA Homo sapiens 322 ccctttgcgt ttatttttgc 20 323 20 DNA Homo sapiens 323 cccacagcct cactttgaac 20 324 22 DNA Homo sapiens 324 tcattagcat gctttggaag tg 22 325 21 DNA Homo sapiens 325 tccttgattc tccttcattg c 21 326 20 DNA Homo sapiens 326 ggggagtgag tgctaactgg 20 327 20 DNA Homo sapiens 327 gatggacacc cagcttcttc 20 328 21 DNA Homo sapiens 328 gctttgcata tgcctaagga g 21 329 20 DNA Homo sapiens 329 gcatctttta gcaccagcag 20 330 20 DNA Homo sapiens 330 ttgccttctg tctctgttgc 20 331 23 DNA Homo sapiens 331 tgagaaaaca aaaccaagag tgg 23 332 20 DNA Homo sapiens 332 gttaggtggc aggattaggg 20 333 20 DNA Homo sapiens 333 tatcagggca gtcctgtgtg 20 334 20 DNA Homo sapiens 334 ccaaggccga gaaactctac 20 335 20 DNA Homo sapiens 335 ctgggtggtg ttgctagatg 20 336 21 DNA Homo sapiens 336 ggaggggaac tttaagggaa c 21 337 21 DNA Homo sapiens 337 aagggaactg gattgtgact g 21 338 21 DNA Homo sapiens 338 tgggacatac acaaagcaat g 21 339 20 DNA Homo sapiens 339 actgtgtgca agggcctatc 20 340 20 DNA Homo sapiens 340 aggatgctca ccctctcttg 20 341 20 DNA Homo sapiens 341 tcctaggggc tgtactttgg 20 342 20 DNA Homo sapiens 342 gatccggaag tacacgatgc 20 343 20 DNA Homo sapiens 343 ggcagttaca gcggagaagg 20 344 20 DNA Homo sapiens 344 tccaggctgg tactttgagc 20 345 20 DNA Homo sapiens 345 gtatgcacct gggctctttg 20 346 20 DNA Homo sapiens 346 ggctctttgc aggtctctcc 20 347 20 DNA Homo sapiens 347 ggttaggtga aggaccaagg 20 348 20 DNA Homo sapiens 348 ctgtctcctg gcatcacatc 20 349 20 DNA Homo sapiens 349 tctaccacct gagggctttg 20 350 19 DNA Homo sapiens 350 ggctaagagc accctcctg 19 351 20 DNA Homo sapiens 351 ctctgtcctg tgtggagagc 20 352 20 DNA Homo sapiens 352 aatgtggctg tcacaaaacg 20 353 20 DNA Homo sapiens 353 tgggaccatg ttggaagttg 20 354 20 DNA Homo sapiens 354 acttccaggg cattggactc 20 355 22 DNA Homo sapiens 355 gagcctggta aaatgtcaga gc 22 356 21 DNA Homo sapiens 356 catcgttttg acttgttgca g 21 357 20 DNA Homo sapiens 357 tggactcttt cagctgttgc 20 358 19 DNA Homo sapiens 358 gcctaggtgc caaggagtc 19 359 20 DNA Homo sapiens 359 tccatcccac ctgagaactg 20 360 19 DNA Homo sapiens 360 agcctccttt tgcttggtg 19 361 19 DNA Homo sapiens 361 taagggtggg tcccaactg 19 362 20 DNA Homo sapiens 362 ctcactgagt tgctggaacg 20 363 21 DNA Homo sapiens 363 gacccaattc tttcacattc g 21 364 27 DNA Homo sapiens 364 aatatataac cagggagaac ctgatac 27 365 23 DNA Homo sapiens 365 ttttattgct ctcaaaacga agg 23 366 20 DNA Homo sapiens 366 aggctgcgtg agacttaacc 20 367 20 DNA Homo sapiens 367 ttccaggagt gtgtgctgtc 20 368 20 DNA Homo sapiens 368 cccattgaac accaggagaa 20 369 20 DNA Homo sapiens 369 caagctcccg atctcaagtg 20 370 21 DNA Homo sapiens 370 cccaactgac tccaacatca c 21 371 20 DNA Homo sapiens 371 tgcccgaaga atgagatcag 20 372 20 DNA Homo sapiens 372 atgtccctgc cactcttcag 20 373 20 DNA Homo sapiens 373 agccatccat tacaggcttc 20 374 22 DNA Homo sapiens 374 tctccccagt gagataaatt cc 22 375 26 DNA Homo sapiens 375 gaagaaaatg tgaaggaaat acagac 26 376 19 DNA Homo sapiens 376 gtcatgtggg ctgaaatgc 19 377 21 DNA Homo sapiens 377 ttaatgtgca aaccagtgtg g 21 378 20 DNA Homo sapiens 378 actcagggaa gtggcttgtg 20 379 21 DNA Homo sapiens 379 gcaccagtac cctattgatg g 21 380 21 DNA Homo sapiens 380 gcaccagtac cctattgatg g 21 381 18 DNA Homo sapiens 381 cctctccagg gtggtgtg 18 382 20 DNA Homo sapiens 382 gccctgcatt taatttgtgg 20 383 20 DNA Homo sapiens 383 gtgtggtgtg cccttttacc 20 384 19 DNA Homo sapiens 384 cacgaattcc tggtcatgc 19 385 20 DNA Homo sapiens 385 ctggagactt ggcctttctg 20 386 20 DNA Homo sapiens 386 tcccttcgcc ccactaatac 20 387 22 DNA Homo sapiens 387 tcacgatcca ttttgagaag tg 22 388 20 DNA Homo sapiens 388 gcctggaaaa atctctggtg 20 389 20 DNA Homo sapiens 389 gagaggtgct cccttcacag 20 390 18 DNA Homo sapiens 390 gagctgctct cggaaatg 18 391 20 DNA Homo sapiens 391 gcaaggattt gctgagcttc 20 392 22 DNA Homo sapiens 392 cccaaaccta aaaatgaagc ag 22 393 33 DNA Homo sapiens 393 agagctatta atataatagc tgagatcaga agt 33 394 21 DNA Homo sapiens 394 tgaaggcctg tcagattatg g 21 395 20 DNA Homo sapiens 395 gggtgacaga gcgagacttc 20 396 30 DNA Homo sapiens 396 cacctttaat gtataataaa gttttgtcat 30 397 20 DNA Homo sapiens 397 atgaagcaac cgtgttgaag 20 398 21 DNA Homo sapiens 398 tcaggcctgc tgtgataact c 21 399 20 DNA Homo sapiens 399 caggcctgct gtgataactc 20 400 26 DNA Homo sapiens 400 tgaaaaggtt tgaaaacata caaaag 26 401 20 DNA Homo sapiens 401 tgcggagctt ccagataaac 20 402 20 DNA Homo sapiens 402 ccctcatacc cgactctctg 20 403 20 DNA Homo sapiens 403 aaattggcta gatgggcaag 20 404 20 DNA Homo sapiens 404 tcctcgtggg agtttacagg 20 405 20 DNA Homo sapiens 405 aggatgcctt ccaaaatcag 20 406 20 DNA Homo sapiens 406 cctctttcca cctagggatg 20 407 21 DNA Homo sapiens 407 cgcagtggtc ctttctactt g 21 408 20 DNA Homo sapiens 408 cttccagccc tgtctctcag 20 409 21 DNA Homo sapiens 409 cctctgagtt cctgtccctt c 21 410 21 DNA Homo sapiens 410 ttcagccttg tatccatttg c 21 411 22 DNA Homo sapiens 411 tcaaaatgtt tcacagaaat gc 22 412 25 DNA Homo sapiens 412 ggcaactaaa aatgagaagt tttcc 25 413 24 DNA Homo sapiens 413 tcagttgtta tccttttagg caac 24 414 21 DNA Homo sapiens 414 tccacaaatg aaaggaacac c 21 415 20 DNA Homo sapiens 415 ccacaaatga aaggaacacc 20 416 20 DNA Homo sapiens 416 gaacggtccg gacataacac 20 417 20 DNA Homo sapiens 417 tgtcactgcc agtttctgtg 20 418 22 DNA Homo sapiens 418 tgtacatctt gcaggtcaaa gg 22 419 25 DNA Homo sapiens 419 aaaaattaga agacaggcaa agttc 25 420 21 DNA Homo sapiens 420 aactcacagg gctttaccaa g 21 421 20 DNA Homo sapiens 421 catgaccatc ttccaagcag 20 422 24 DNA Homo sapiens 422 ccaaaattat cttatttggc tgtc 24 423 21 DNA Homo sapiens 423 caagatgggt agacctgatg c 21 424 20 DNA Homo sapiens 424 atcctgcact tcacgcactc 20 425 19 DNA Homo sapiens 425 gcctcctgga tgctttagg 19 426 18 DNA Homo sapiens 426 atctgctgca ggggtgtg 18 427 18 DNA Homo sapiens 427 atctgctgca ggggtgtg 18 428 20 DNA Homo sapiens 428 ggaccccgta gtcatctcag 20 429 20 DNA Homo sapiens 429 gggtcaaact cccagagagc 20 430 20 DNA Homo sapiens 430 acccccttat agtgccgaag 20 431 21 DNA Homo sapiens 431 cagaagcagc ccatctacat c 21 432 20 DNA Homo sapiens 432 ggagttggcc tctgtggtag 20 433 21 DNA Homo sapiens 433 gcacctgagg cccttaacta c 21 434 20 DNA Homo sapiens 434 ttggtggaga acagtgcatc 20 435 20 DNA Homo sapiens 435 cctgcttcac ctcctttctg 20 436 20 DNA Homo sapiens 436 gtagcatggc agggtttgac 20 437 20 DNA Homo sapiens 437 catccaggga aaggttaagg 20 438 21 DNA Homo sapiens 438 agtggagatg ctgtgtgtgt g 21 439 20 DNA Homo sapiens 439 gtggtcgtct gctggtgtag 20 440 22 DNA Homo sapiens 440 tccttgcaat tgaatgtctt tg 22 441 20 DNA Homo sapiens 441 ccatgtggat ggcattattc 20 442 20 DNA Homo sapiens 442 accaaatctt gtggacatgg 20 443 20 DNA Homo sapiens 443 gtcaggagtc agggacgatg 20 444 21 DNA Homo sapiens 444 ccttcatcaa gctgagtgac c 21 445 20 DNA Homo sapiens 445 ccctggatcc tgctaaggtc 20 446 20 DNA Homo sapiens 446 tgccataatg cacagagagg 20 447 20 DNA Homo sapiens 447 tcgaggagag acacctcaag 20 448 20 DNA Homo sapiens 448 tcgaggagag acacctcaag 20 449 21 DNA Homo sapiens 449 tgcggttccc atattacagt c 21 450 20 DNA Homo sapiens 450 atgtgtcatt gttgcggttc 20 451 20 DNA Homo sapiens 451 gctcgggggt agggttatag 20 452 20 DNA Homo sapiens 452 gaaaccgaga ccctggagac 20 453 20 DNA Homo sapiens 453 cgcttcctca cctttctgac 20 454 20 DNA Homo sapiens 454 gctcttgctt tggctactgg 20 455 19 DNA Homo sapiens 455 gggtttctcc tgctcatgg 19 456 20 DNA Homo sapiens 456 gagtccctcc tgggtagtcc 20 457 19 DNA Homo sapiens 457 cccttccttc cttccagtg 19 458 20 DNA Homo sapiens 458 ctcctgcctg ggacagtatc 20 459 20 DNA Homo sapiens 459 agtctgctct ctggggtttg 20 460 19 DNA Homo sapiens 460 ggcctcccaa agtgttgag 19 461 21 DNA

Homo sapiens 461 tcctgggctc aaataatacc c 21 462 27 DNA Homo sapiens 462 ttaaccattt ttaagggtat agttcag 27 463 21 DNA Homo sapiens 463 tgctgttgat tgaatggtct g 21 464 25 DNA Homo sapiens 464 ttagttcatc actggtgata ttgac 25 465 20 DNA Homo sapiens 465 gggaaggctt tactcgtttg 20 466 19 DNA Homo sapiens 466 caaaaagcat ggccaaatg 19 467 20 DNA Homo sapiens 467 aaacaaattg ggcaaaaagc 20 468 22 DNA Homo sapiens 468 tgaggactgg taaatcacaa gc 22 469 18 DNA Homo sapiens 469 acattgagcg ccttggtc 18 470 20 DNA Homo sapiens 470 ttgcctgttt tgttcactgc 20 471 18 DNA Homo sapiens 471 ttggcctctc caaagcac 18 472 20 DNA Homo sapiens 472 gtctggagct atggggtcac 20 473 20 DNA Homo sapiens 473 agccctgctg actttctgag 20 474 21 DNA Homo sapiens 474 tttcattgac ggagaatcca c 21 475 20 DNA Homo sapiens 475 cggagaatcc acaactatgc 20 476 18 DNA Homo sapiens 476 acctggagtg tggccttg 18 477 19 DNA Homo sapiens 477 tgtggatgtg caggaacac 19 478 20 DNA Homo sapiens 478 tggttaatgg acagcgtagg 20 479 19 DNA Homo sapiens 479 catggaggtg ggaaatgtg 19 480 20 DNA Homo sapiens 480 cagggtcact ggattagcag 20 481 20 DNA Homo sapiens 481 ccccaaggga ctttatcagg 20 482 20 DNA Homo sapiens 482 cggccccttt tgtgtatttc 20 483 18 DNA Homo sapiens 483 gggtggatgt ggatctgc 18 484 21 DNA Homo sapiens 484 ttttgagcca tgttctctag c 21 485 21 DNA Homo sapiens 485 tgaatcctgg aaatcaacga g 21 486 20 DNA Homo sapiens 486 tgctgcttat ggacaactcc 20 487 21 DNA Homo sapiens 487 tctgtcattg cttagctgtg g 21 488 20 DNA Homo sapiens 488 tggaaactgc aaaactgcac 20 489 22 DNA Homo sapiens 489 ccctgttaac atcatctcct tc 22 490 18 DNA Homo sapiens 490 cctgggacag gtcacgtc 18 491 20 DNA Homo sapiens 491 cttcggggac aggacttatc 20 492 20 DNA Homo sapiens 492 gtagatgcct ggctttgagg 20 493 20 DNA Homo sapiens 493 tgactgggtt tgtcacatgg 20 494 20 DNA Homo sapiens 494 ttgccttttg agtgacaagc 20 495 21 DNA Homo sapiens 495 cacttgcctg aagaagtgtg g 21 496 22 DNA Homo sapiens 496 tgaaggatga ttcacgctag tc 22 497 25 DNA Homo sapiens 497 tgagttttac ttgggaaacc ataac 25 498 23 DNA Homo sapiens 498 tgcagtaatc gtttcttctc tgg 23 499 21 DNA Homo sapiens 499 tcaggaaatt gaatgaaatg c 21 500 21 DNA Homo sapiens 500 gcctttcatt ggcttttaac c 21 501 22 DNA Homo sapiens 501 tttttctgcc tgaacttgtc tg 22 502 24 DNA Homo sapiens 502 tcacaaagaa gacatgaaca tctg 24 503 27 DNA Homo sapiens 503 cacacctacg tacctatagt ggtattg 27 504 20 DNA Homo sapiens 504 aaaccctcag gacaagatgc 20 505 20 DNA Homo sapiens 505 aggcttgagc cattaagacc 20 506 20 DNA Homo sapiens 506 tggcaatgtc aatgtcaagc 20 507 20 DNA Homo sapiens 507 tgttgcccaa aacagaaacc 20 508 20 DNA Homo sapiens 508 tcctacaacc cgaatactgc 20 509 21 DNA Homo sapiens 509 tgtcaaagca acagtccaca c 21 510 20 DNA Homo sapiens 510 aatgggttga tggaggaatg 20 511 20 DNA Homo sapiens 511 ggccacgtat caggaaattg 20 512 20 DNA Homo sapiens 512 gctgagggtg gaagtctgtc 20 513 19 DNA Homo sapiens 513 gcacttctgc ccaggtgtc 19 514 20 DNA Homo sapiens 514 tgggaatgtc tctgatggtg 20 515 20 DNA Homo sapiens 515 catgatttcg cttccctctc 20 516 24 DNA Homo sapiens 516 tctcaaacac taggaattgc aaac 24 517 20 DNA Homo sapiens 517 atgagtgggc cattgagaag 20 518 20 DNA Homo sapiens 518 gtcccaaagc atctgagtcc 20 519 20 DNA Homo sapiens 519 ggtcccaaag catctgagtc 20 520 20 DNA Homo sapiens 520 ggtaagtttg gggcacaatg 20 521 20 DNA Homo sapiens 521 ccaggaggtg aaagtggttg 20 522 21 DNA Homo sapiens 522 catacccctt cacctgtgtt c 21 523 19 DNA Homo sapiens 523 ccccactccc cagtactcc 19 524 19 DNA Homo sapiens 524 agtgggaagg gacaagtgg 19 525 20 DNA Homo sapiens 525 aagtgacctg cagggagttg 20 526 19 DNA Homo sapiens 526 gacttctggc tgggggtag 19 527 18 DNA Homo sapiens 527 gcccgggaac agtttctc 18 528 20 DNA Homo sapiens 528 agtttcctga ggcacagtcg 20 529 20 DNA Homo sapiens 529 ccacaggtta ggagcagtcc 20 530 19 DNA Homo sapiens 530 gattggggac tttgggatg 19 531 20 DNA Homo sapiens 531 cctggtgata acacccttcc 20 532 19 DNA Homo sapiens 532 ctggacttcg tcgttggag 19 533 19 DNA Homo sapiens 533 gtgctggact tcgtcgttg 19 534 20 DNA Homo sapiens 534 ctagctttgc cagcatcttg 20 535 21 DNA Homo sapiens 535 ccattttcca atctccttca g 21 536 20 DNA Homo sapiens 536 gcgtgctgtc aaacagattc 20 537 20 DNA Homo sapiens 537 gacactgcgt gctgtcaaac 20 538 20 DNA Homo sapiens 538 tgcagcaaat ggaaatagcc 20 539 23 DNA Homo sapiens 539 ttagcatttg catatttttc ctc 23 540 23 DNA Homo sapiens 540 ttgaaattga tgcaaagatt gtg 23 541 21 DNA Homo sapiens 541 cccttttctg actgcttttt g 21 542 25 DNA Homo sapiens 542 aataaaaatt tctgggtaag ctttg 25 543 19 DNA Homo sapiens 543 aattttagcc cccatgcag 19 544 20 DNA Homo sapiens 544 aggagctcca tcacatcagg 20 545 20 DNA Homo sapiens 545 ctggacagct gcctctactg 20 546 20 DNA Homo sapiens 546 ggattacagg cgtgaaccac 20 547 20 DNA Homo sapiens 547 agctaagaag cccagacgag 20 548 20 DNA Homo sapiens 548 tccagaagac cttcttgcag 20 549 19 DNA Homo sapiens 549 gtcatggttg gggttaggg 19 550 20 DNA Homo sapiens 550 aggtagggac caggaagacc 20 551 21 DNA Homo sapiens 551 ccctactttc cagggttctt g 21 552 20 DNA Homo sapiens 552 tccattgagc ccctactttc 20 553 20 DNA Homo sapiens 553 gggatcttca ccacccactc 20 554 21 DNA Homo sapiens 554 cccatttaat cccttctcac c 21 555 20 DNA Homo sapiens 555 ctatcccaaa cccccaagac 20 556 18 DNA Homo sapiens 556 cagagggagc gtgtgacc 18 557 20 DNA Homo sapiens 557 ctgtcctcct ggttcaggtc 20 558 20 DNA Homo sapiens 558 cagaagtagt ggcgcacttg 20 559 19 DNA Homo sapiens 559 ggctgtgttg tccctctgg 19 560 18 DNA Homo sapiens 560 gagcggccct actggaac 18 561 20 DNA Homo sapiens 561 tttggccctg acactaggac 20 562 20 DNA Homo sapiens 562 ctctctgggc atggtgctac 20 563 20 DNA Homo sapiens 563 tcatccaggc tagaatgcag 20 564 21 DNA Homo sapiens 564 gtcatccagg ctagaatgca g 21 565 20 DNA Homo sapiens 565 gcttcttcca gtgctcatcc 20 566 20 DNA Homo sapiens 566 attttcccac tggattctgg 20 567 21 DNA Homo sapiens 567 ttgcactatt gcactccagt c 21 568 21 DNA Homo sapiens 568 aggaacaagg agacattgtg g 21 569 19 DNA Homo sapiens 569 cccactcctt ccctgtctc 19 570 20 DNA Homo sapiens 570 tggactacct gcggtctagg 20 571 20 DNA Homo sapiens 571 ctgaggccct gagagagaag 20 572 19 DNA Homo sapiens 572 agctcacagg ccactctcc 19 573 20 DNA Homo sapiens 573 ccctgaacat gaaggagctg 20 574 20 DNA Homo sapiens 574 attaagaacg acgccactgc 20 575 20 DNA Homo sapiens 575 tcgacccact atgggagttc 20 576 20 DNA Homo sapiens 576 cagcctagca aggattcagc 20 577 20 DNA Homo sapiens 577 tcatcaacct gcttggtgtc 20 578 21 DNA Homo sapiens 578 aaaccttgac ctcctcctct g 21 579 21 DNA Homo sapiens 579 tccccgtttc taaaccttga c 21 580 20 DNA Homo sapiens 580 agaaaaccag caacgtgagg 20 581 20 DNA Homo sapiens 581 agaaaaccag caacgtgagg 20 582 20 DNA Homo sapiens 582 gcccagacta ccaggaggag 20 583 20 DNA Homo sapiens 583 tgaccctcct atccctcatc 20 584 20 DNA Homo sapiens 584 ggcatcctta ccctgaacac 20 585 20 DNA Homo sapiens 585 caacaaactc ctggacatgg 20 586 20 DNA Homo sapiens 586 tgcaagattg cagactttgg 20 587 23 DNA Homo sapiens 587 ccttaccatt gatgaagacc aag 23 588 23 DNA Homo sapiens 588 tgaccttacc attgatgaag acc 23 589 18 DNA Homo sapiens 589 gtggagacac ggggtgag 18 590 20 DNA Homo sapiens 590 cccaagtgtt tgggtgacag 20 591 20 DNA Homo sapiens 591 gaggtgtgga tgggtgagtg 20 592 20 DNA Homo sapiens 592 ggctacgttc tgggcctaag 20 593 20 DNA Homo sapiens 593 agagggtgct gtttgcagag 20 594 20 DNA Homo sapiens 594 gtctgcacgg ccttgtactg 20 595 18 DNA Homo sapiens 595 gtactgggcc agcctctg 18 596 21 DNA Homo sapiens 596 gcttggacca gaagggttat c 21 597 19 DNA Homo sapiens 597 aggtctgcct ccctcactg 19 598 20 DNA Homo sapiens 598 gcattaggga aaaggcttcc 20 599 20 DNA Homo sapiens 599 aggcatgctg attcctgaag 20 600 19 DNA Homo sapiens 600 ctggcctcat ccatcttcc 19 601 20 DNA Homo sapiens 601 cttgtgctgc ttcacctctg 20 602 21 DNA Homo sapiens 602 aatgtggtga atcgaggttt g 21 603 20 DNA Homo sapiens 603 gctgtgggag cttgtgtctc 20 604 19 DNA Homo sapiens 604 cctgggggag tttctttcc 19 605 20 DNA Homo sapiens 605 tgcgtaagct ctctgtggac 20 606 20 DNA Homo sapiens 606 gcactcagct gcgaagtatg 20 607 19 DNA Homo sapiens 607 atggtacccg tggggacag 19 608 20 DNA Homo sapiens 608 caggatttgg agcctcagtc 20 609 19 DNA Homo sapiens 609 tgcatccttg tggagatgc 19 610 19 DNA Homo sapiens 610 tcccacccca caactcttc 19 611 20 DNA Homo sapiens 611 tgtcatgaag caggttaggc 20 612 21 DNA Homo sapiens 612 ttggtctttt gatcattttg c 21 613 22 DNA Homo sapiens 613 tccaggtgtc aatttctctg tc 22 614 20 DNA Homo sapiens 614 aacgcaaggg attcatcaag 20 615 21 DNA Homo sapiens 615 tggcattttc agaattcctt g 21 616 20 DNA Homo sapiens 616 ggaaaaatgg acaccacacc 20 617 24 DNA Homo sapiens 617 tggattctct ctctgcatta caac 24 618 20 DNA Homo sapiens 618 tcacgtagcc acaagaccac 20 619 21 DNA Homo sapiens 619 tgcctccaaa gataattgtg c 21 620 23 DNA Homo sapiens 620 ttccctctct ttctctgttc aag 23 621 20 DNA Homo sapiens 621 tttagagcac ttgggggttg 20 622 21 DNA Homo sapiens 622 gctaagccca cacattgaaa g 21 623 19 DNA Homo sapiens 623 gggatccctc actctgacc 19 624 20 DNA Homo sapiens 624 gcgtccttgc cttatttctg 20 625 20 DNA Homo sapiens 625 gtgcacgaag caagaatagc 20 626 20 DNA Homo sapiens 626 gaaggtgtgc aagcacagag 20 627 20 DNA Homo sapiens 627 ccagggctcc actataatcc 20 628 20 DNA Homo sapiens 628 agttgcccag tccctaatcc 20 629 20 DNA Homo sapiens 629 agaaaagttg cagcctggtg 20 630 20 DNA Homo sapiens 630 tgccatgaac tggttacagc 20 631 20 DNA Homo sapiens 631 aggacacagt gagtggcttg 20 632 19 DNA Homo sapiens 632 tgcaagcagc agaggaaac 19 633 20 DNA Homo sapiens 633 gaaggggcag agtcagtgtg 20 634 20 DNA Homo sapiens 634 actgcctgct gacctctgac 20 635 20 DNA Homo sapiens 635 cgagagcaac atctggtgag 20 636 20 DNA Homo sapiens 636 ggtctctgtc cccctctctc 20 637 19 DNA Homo sapiens 637 gagtgcctgt gggagaagg 19 638 20 DNA Homo sapiens 638 aaaaggtgtc gcagaggatg 20 639 20 DNA Homo sapiens 639 cctagtccca tccacaggag 20 640 20 DNA Homo sapiens 640

tgaggtggga gagttgcttg 20 641 19 DNA Homo sapiens 641 ggctgaggtg ggagagttg 19 642 20 DNA Homo sapiens 642 actgaaacct ccacctcctg 20 643 20 DNA Homo sapiens 643 tgagagccat cctgcaagtc 20 644 20 DNA Homo sapiens 644 aaatctgatg ccggtctttg 20 645 20 DNA Homo sapiens 645 atctgatgcc ggtctttgtg 20 646 19 DNA Homo sapiens 646 tcaatatctg gccccttcc 19 647 19 DNA Homo sapiens 647 ttgttttggg gagggaatg 19 648 20 DNA Homo sapiens 648 tgatgccctt gtatgacagc 20 649 20 DNA Homo sapiens 649 tggtgggaga aaaccaagtc 20 650 20 DNA Homo sapiens 650 tgcacttctg gaggtagcac 20 651 20 DNA Homo sapiens 651 tgggatccat gtaggagacc 20 652 22 DNA Homo sapiens 652 ttgaacaata tctgccacct tg 22 653 25 DNA Homo sapiens 653 ggaaaaagat aatttatttg ccatc 25 654 20 DNA Homo sapiens 654 gtcccccaaa tcaggttttc 20 655 20 DNA Homo sapiens 655 attaaggcca gcccaaagac 20 656 21 DNA Homo sapiens 656 tggatgcagg aatttatgga g 21 657 22 DNA Homo sapiens 657 gccttaccaa ttgagtcgtt tc 22 658 20 DNA Homo sapiens 658 ccggtggttg tgctaaagac 20 659 20 DNA Homo sapiens 659 tgtgcacttt ttcccctttg 20 660 20 DNA Homo sapiens 660 gtatgttacc cccgcctctc 20 661 21 DNA Homo sapiens 661 gcaagtggct gtgaaggtaa g 21 662 20 DNA Homo sapiens 662 tgcccatgtt tacagaatgc 20 663 20 DNA Homo sapiens 663 ctttcaaatg cctccaggtg 20 664 21 DNA Homo sapiens 664 ggaaatatag ggaagggaag g 21 665 19 DNA Homo sapiens 665 cctgctctcc tcctgaacc 19 666 23 DNA Homo sapiens 666 tgttatggaa aagggtataa tgg 23 667 18 DNA Homo sapiens 667 cagctggtgg aggtgctg 18 668 18 DNA Homo sapiens 668 ctctgcctgg tgctggag 18 669 23 DNA Homo sapiens 669 caggcacaga taacccacta aag 23 670 20 DNA Homo sapiens 670 ccatttaggg gcttttctgg 20 671 20 DNA Homo sapiens 671 gccatttagg ggcttttctg 20 672 24 DNA Homo sapiens 672 ggagcagata ctataaatgg aagc 24 673 21 DNA Homo sapiens 673 gggaatttca gcttctcctt g 21 674 25 DNA Homo sapiens 674 tttgtaaata acatttcgct tttcc 25 675 22 DNA Homo sapiens 675 gcttctttct agagctgcca ac 22 676 22 DNA Homo sapiens 676 tgcctgtttc cttttatgat tc 22 677 24 DNA Homo sapiens 677 aaccaaagat ttgggtcttt ttac 24 678 20 DNA Homo sapiens 678 agagtgcttc ctggatttgg 20 679 20 DNA Homo sapiens 679 tttgtgccag gaatagatgg 20 680 22 DNA Homo sapiens 680 tgtacacaca gaggatgagc ag 22 681 20 DNA Homo sapiens 681 acctttggca gttcagatgc 20 682 20 DNA Homo sapiens 682 ctttggcagt tcagatgcag 20 683 20 DNA Homo sapiens 683 ctattcggga aggtgcaatg 20 684 20 DNA Homo sapiens 684 agggtgtttc cactctctgc 20 685 19 DNA Homo sapiens 685 cggatgcttg ttggacttc 19 686 20 DNA Homo sapiens 686 tgtgaagtgg tgtccacctg 20 687 20 DNA Homo sapiens 687 acaagacccc tttggagatg 20 688 20 DNA Homo sapiens 688 cctttggaga tgcctgtatg 20 689 20 DNA Homo sapiens 689 atgtggagca ctgtgattgg 20 690 19 DNA Homo sapiens 690 gagggggtca cagcagaac 19 691 20 DNA Homo sapiens 691 ccaggctagc ttaggccttc 20 692 20 DNA Homo sapiens 692 tgtgcttctg ggcttcctac 20 693 20 DNA Homo sapiens 693 ctgaggctgt tgtgcttctg 20 694 20 DNA Homo sapiens 694 ctgaggctgt tgtgcttctg 20 695 20 DNA Homo sapiens 695 cgcatgtgac caatttcttg 20 696 20 DNA Homo sapiens 696 caggggagtc atctttttcc 20 697 20 DNA Homo sapiens 697 gagccaagat cacaccactg 20 698 20 DNA Homo sapiens 698 ttgcaaaatc ctcaatgctg 20 699 20 DNA Homo sapiens 699 ttgcaaaatc ctcaatgctg 20 700 22 DNA Homo sapiens 700 gctgctgatg gagtattgaa gg 22 701 25 DNA Homo sapiens 701 gaagctttaa atttcatgcc ttatg 25 702 23 DNA Homo sapiens 702 ccctaaacct gagtgatctg atg 23 703 20 DNA Homo sapiens 703 ctgggggttc cgtatctttg 20 704 19 DNA Homo sapiens 704 tgggggttcc gtatctttg 19 705 19 DNA Homo sapiens 705 gaagaaatcg gggtgttgg 19 706 21 DNA Homo sapiens 706 gatgggagag tgggaagaat c 21 707 21 DNA Homo sapiens 707 gccaatacag cgtatcagag g 21 708 20 DNA Homo sapiens 708 aagcctgggt tcccatagag 20 709 20 DNA Homo sapiens 709 catggggtac tgcagtcagg 20 710 19 DNA Homo sapiens 710 atggggtact gcagtcagg 19 711 20 DNA Homo sapiens 711 atcccatgca cagcctagag 20 712 20 DNA Homo sapiens 712 atgcaccgag agatctgagg 20 713 21 DNA Homo sapiens 713 ggagcaacac agtcaccttt c 21 714 19 DNA Homo sapiens 714 gtcctggtgt gcggtagtg 19 715 20 DNA Homo sapiens 715 gaggctggag aagtggtctg 20 716 20 DNA Homo sapiens 716 caaggtacgc accacacaac 20 717 20 DNA Homo sapiens 717 ggggagtgga gaaggagaag 20 718 20 DNA Homo sapiens 718 aagagagggg tgaacagtgc 20 719 20 DNA Homo sapiens 719 gagaggggtg aacagtgcag 20 720 20 DNA Homo sapiens 720 gaacattttg ccagctttgg 20 721 20 DNA Homo sapiens 721 cccgattctg ctctggagtc 20 722 20 DNA Homo sapiens 722 gctgaagcca aaaattccag 20 723 20 DNA Homo sapiens 723 cacttgtccc tcaggcagac 20 724 20 DNA Homo sapiens 724 aaacggaaat gggacctagc 20 725 20 DNA Homo sapiens 725 tgtccctcaa ctttccttcc 20 726 20 DNA Homo sapiens 726 tggcttcata tcctctccac 20 727 20 DNA Homo sapiens 727 cttcctctgt gtttgggttg 20 728 22 DNA Homo sapiens 728 aaaatgactt ggcgttacac ac 22 729 20 DNA Homo sapiens 729 aggcatccac aacctttctg 20 730 20 DNA Homo sapiens 730 accgctgtta ttcaggatgg 20 731 20 DNA Homo sapiens 731 aatcagacct tggcgatgac 20 732 20 DNA Homo sapiens 732 tgttcaagtc ctccctcctg 20 733 20 DNA Homo sapiens 733 gtctcaggtt gcagggtctc 20 734 20 DNA Homo sapiens 734 ctccctccac acacacacac 20 735 19 DNA Homo sapiens 735 cggggtgctt gatgaatag 19 736 20 DNA Homo sapiens 736 ccttccctca ttgagattcc 20 737 20 DNA Homo sapiens 737 gcatacatca aaccccttgg 20 738 21 DNA Homo sapiens 738 aaccatttca tccaccattt g 21 739 19 DNA Homo sapiens 739 ctacctgggg cttttcctg 19 740 18 DNA Homo sapiens 740 gggtgggcta ttgggaac 18 741 19 DNA Homo sapiens 741 gtgggaatca ccagggaag 19 742 20 DNA Homo sapiens 742 aaaaatggga gttggggaag 20 743 21 DNA Homo sapiens 743 ctcaccaatg acatcgtcaa g 21 744 20 DNA Homo sapiens 744 tcacccatga aaaagggaag 20 745 19 DNA Homo sapiens 745 accacccttt gacccattg 19 746 20 DNA Homo sapiens 746 gaattccccc tccatctctg 20 747 20 DNA Homo sapiens 747 cccaacaaca aaaaggaagg 20 748 20 DNA Homo sapiens 748 aggtccttgt cagtggcatc 20 749 18 DNA Homo sapiens 749 gacacgggct cctcagac 18 750 18 DNA Homo sapiens 750 gtggatgcac tggggaag 18 751 19 DNA Homo sapiens 751 cggtcaaaca aggcctcag 19 752 20 DNA Homo sapiens 752 gggaggggta gaaaccacac 20 753 18 DNA Homo sapiens 753 cctgaggacc cagtggag 18 754 19 DNA Homo sapiens 754 ccacacctca gcactctgg 19 755 21 DNA Homo sapiens 755 tgtctctcca tctgcactga g 21 756 18 DNA Homo sapiens 756 aagcccccta cagccaac 18 757 22 DNA Homo sapiens 757 tgcagaagaa agagaaatgt gc 22 758 20 DNA Homo sapiens 758 cgaatggcca cttattgttg 20 759 22 DNA Homo sapiens 759 ccaccttggt acatatggct tc 22 760 20 DNA Homo sapiens 760 gtaggcaggc caactcagac 20 761 22 DNA Homo sapiens 761 aagcatgatt gcataacaaa gg 22 762 21 DNA Homo sapiens 762 ccacctgagt cctctaccat c 21 763 24 DNA Homo sapiens 763 tcatcccttt tcatatatgt gtgg 24 764 20 DNA Homo sapiens 764 tggtattcaa gggcacatca 20 765 23 DNA Homo sapiens 765 gactcattag cagacggaca ctc 23 766 21 DNA Homo sapiens 766 tccctggaaa gaaaatgtgt g 21 767 20 DNA Homo sapiens 767 ccaccgaaca caacaaacac 20 768 20 DNA Homo sapiens 768 aggaggcttc aagggatgag 20 769 22 DNA Homo sapiens 769 ggccatttaa ttcttgtcct tg 22 770 20 DNA Homo sapiens 770 cttgcctgcc tcctctaatg 20 771 21 DNA Homo sapiens 771 gatgattacg cagctcaaag c 21 772 19 DNA Homo sapiens 772 agcaatctgt gcaccaagc 19 773 20 DNA Homo sapiens 773 ccacctgttc caacacttcc 20 774 20 DNA Homo sapiens 774 gtgcttggta ggcattaggg 20 775 20 DNA Homo sapiens 775 ctaccgctcc tagccctacc 20 776 20 DNA Homo sapiens 776 gttggttcag ggatctgagg 20 777 20 DNA Homo sapiens 777 gtcttgtcag gaccctctcc 20 778 20 DNA Homo sapiens 778 cacacctggt cccttagtgg 20 779 20 DNA Homo sapiens 779 cacacctggt cccttagtgg 20 780 19 DNA Homo sapiens 780 ctctcaggca cagctggag 19 781 19 DNA Homo sapiens 781 gagcccagaa ttgcctctc 19 782 20 DNA Homo sapiens 782 ctgcattgct tatcctggtg 20 783 20 DNA Homo sapiens 783 cagtccaccc taccccagag 20 784 20 DNA Homo sapiens 784 cctcagtggg ttgttgtgtg 20 785 22 DNA Homo sapiens 785 cagaggcacg cctaacttat ag 22 786 20 DNA Homo sapiens 786 cggcagaaaa cgctagaatg 20 787 20 DNA Homo sapiens 787 acagtaagca ctccccaagg 20 788 20 DNA Homo sapiens 788 agtctttggt ggctgaatgg 20 789 20 DNA Homo sapiens 789 actgagatag ggcgcttcag 20 790 19 DNA Homo sapiens 790 ccaagcccct attcccatc 19 791 20 DNA Homo sapiens 791 acaaggacgc agaggtcatc 20 792 20 DNA Homo sapiens 792 agaggaaaag gctggaggag 20 793 20 DNA Homo sapiens 793 cagcctgctc ctgtatcctc 20 794 22 DNA Homo sapiens 794 cctttttgtc atctccatgg tc 22 795 22 DNA Homo sapiens 795 cctttttgtc atctccatgg tc 22 796 18 DNA Homo sapiens 796 aggagggccc attctctg 18 797 18 DNA Homo sapiens 797 caaaagcccc tggagacc 18 798 19 DNA Homo sapiens 798 ccagccccac tctccttag 19 799 20 DNA Homo sapiens 799 catcaactga gggcttccag 20 800 20 DNA Homo sapiens 800 ctcgaaggcc ctctttaacc 20 801 22 DNA Homo sapiens 801 gaggctggat tttcaacaaa ag 22 802 20 DNA Homo sapiens 802 gctgcttgca gactatcagg 20 803 20 DNA Homo sapiens 803 tgttcctcca agaggagtgc 20 804 20 DNA Homo sapiens 804 agagaaggtg caggacaagg 20 805 20 DNA Homo sapiens 805 ttctacccgg ctctcatttc 20 806 19 DNA Homo sapiens 806 aattatgcag cccggacac 19 807 20 DNA Homo sapiens 807 catcaccccc tactggtttg 20 808 20 DNA Homo sapiens 808 tggagcaatc ttttgggaac 20 809 20 DNA Homo sapiens 809 ctttggaagg ctgcaatctc 20 810 20 DNA Homo sapiens 810 ggaaattctc cagctccatc 20 811 22 DNA Homo sapiens 811 tggaggtggc tctctactct tc 22 812 20 DNA Homo sapiens 812 attcgctcaa tggctaatcg 20 813 20 DNA Homo sapiens 813 tcctttgtcc cagctgtttc 20 814 20 DNA Homo sapiens 814 gacgacccct acaggtaagc 20 815 20 DNA Homo sapiens 815 atgggaaggg atgtgctacc 20 816 20 DNA Homo sapiens 816 tcttgggacc tgtgtgtgag 20 817 23 DNA Homo sapiens 817 cagctcatga caacctatga atg 23 818 18 DNA Homo sapiens 818 tgtggttgcc tgccattg 18 819 20 DNA Homo sapiens 819 ttctgcaaac cagcattttg

20 820 22 DNA Homo sapiens 820 gccaagaagt gtatgtcact cg 22 821 21 DNA Homo sapiens 821 gggcctgtag gaatggtaaa c 21 822 27 DNA Homo sapiens 822 tttatactgt tttctaaacc cactgag 27 823 21 DNA Homo sapiens 823 gcaaacacag acaccaaact g 21 824 21 DNA Homo sapiens 824 cattagcaac cctgcagttt c 21 825 20 DNA Homo sapiens 825 tcagcagcat gaaaatggac 20 826 18 DNA Homo sapiens 826 cccacccatt tcctctcc 18 827 19 DNA Homo sapiens 827 gctctgatcc ctgctttgg 19 828 20 DNA Homo sapiens 828 caaggaccct cctccttcac 20 829 20 DNA Homo sapiens 829 gagagcctcc ctcctttcag 20 830 19 DNA Homo sapiens 830 gcaatccaac agccatgag 19 831 19 DNA Homo sapiens 831 gcaatccaac agccatgag 19 832 20 DNA Homo sapiens 832 atctaccctc cctggctttc 20 833 20 DNA Homo sapiens 833 ttctccgaga tccccaatac 20 834 20 DNA Homo sapiens 834 cctctgctcc tacgttgagg 20 835 20 DNA Homo sapiens 835 tgcaggatgg gttttgatac 20 836 20 DNA Homo sapiens 836 acacacacac acgcacacac 20 837 18 DNA Homo sapiens 837 cctgctggtg gctctgtg 18 838 20 DNA Homo sapiens 838 gcctctcgaa gaagttccac 20 839 20 DNA Homo sapiens 839 tcaaacgctg agtccagaag 20 840 23 DNA Homo sapiens 840 gcagcatgac ttgctattaa ctg 23 841 23 DNA Homo sapiens 841 gcagcatgac ttgctattaa ctg 23 842 19 DNA Homo sapiens 842 agaaggctgt cgcttcctc 19 843 23 DNA Homo sapiens 843 aattgcattt gaacgaaaaa tag 23 844 24 DNA Homo sapiens 844 tcatagaaaa cagctgccta actg 24 845 20 DNA Homo sapiens 845 caaactgaag cccaagacac 20 846 22 DNA Homo sapiens 846 gggcttaaaa agtcaaagaa gc 22 847 23 DNA Homo sapiens 847 gactcatgaa gacaaacaaa agc 23 848 23 DNA Homo sapiens 848 gaaagtcaaa tggagttcca cag 23 849 20 DNA Homo sapiens 849 ttacactgaa gggcgggtag 20 850 22 DNA Homo sapiens 850 tggaatgtgt ttaagcaagg ag 22 851 20 DNA Homo sapiens 851 tcttggggga ggtcacttag 20 852 20 DNA Homo sapiens 852 tgtctccagt ttggttcagg 20 853 20 DNA Homo sapiens 853 tctgccacac gagttctttg 20 854 19 DNA Homo sapiens 854 ctggccccag ctaatttgg 19 855 19 DNA Homo sapiens 855 ttcacagtgc agcgaaaac 19 856 21 DNA Homo sapiens 856 gacccatctc catatccact g 21 857 22 DNA Homo sapiens 857 gcggacttaa aacttcttac cc 22 858 20 DNA Homo sapiens 858 ggcatttgca ttatgaaacc 20 859 25 DNA Homo sapiens 859 ttgctagttt gaaggaatta aaatg 25 860 20 DNA Homo sapiens 860 accaccttga ccaccaactc 20 861 20 DNA Homo sapiens 861 accaccttga ccaccaactc 20 862 21 DNA Homo sapiens 862 tgtgcacatg tttttgtttg g 21 863 21 DNA Homo sapiens 863 aggtgcgtag atcacttgag g 21 864 20 DNA Homo sapiens 864 caccccagag aacaatccag 20 865 20 DNA Homo sapiens 865 acaggcgcat tgagagaaac 20 866 20 DNA Homo sapiens 866 gacagaggga gaccccattc 20 867 21 DNA Homo sapiens 867 aagctgagga aaaccttgga g 21 868 20 DNA Homo sapiens 868 ctcttgccac tcttggaacg 20 869 18 DNA Homo sapiens 869 cacctcctca cccacctc 18 870 20 DNA Homo sapiens 870 ggcagaagag ccactaccag 20 871 20 DNA Homo sapiens 871 atggagagag gaaccgaacc 20 872 20 DNA Homo sapiens 872 accccaggct tagaacagac 20 873 20 DNA Homo sapiens 873 atacagatac ggggcgtgag 20 874 20 DNA Homo sapiens 874 tagcccctca gcttgaacac 20 875 18 DNA Homo sapiens 875 gacctgtgcc cttcaagc 18 876 18 DNA Homo sapiens 876 ccaggtcagc atccatcc 18 877 20 DNA Homo sapiens 877 aagggaaaag ggagtcttgg 20 878 21 DNA Homo sapiens 878 tcccttaata tccccatgct c 21 879 20 DNA Homo sapiens 879 gccaggttca cttaccatcc 20 880 20 DNA Homo sapiens 880 ggcagtgtac tgaccccttg 20 881 20 DNA Homo sapiens 881 acaaaaaccc ccatctccac 20 882 19 DNA Homo sapiens 882 cagacctttc cacccacag 19 883 20 DNA Homo sapiens 883 tataggggag gggaaaggtg 20 884 20 DNA Homo sapiens 884 tttctgaacg ggatccagag 20 885 20 DNA Homo sapiens 885 gaactggtct gcatcattgc 20 886 20 DNA Homo sapiens 886 tccaaagaga cagcagttgg 20 887 25 DNA Homo sapiens 887 cttaatttga ctgctaaaat gtgtg 25 888 20 DNA Homo sapiens 888 gataggggct gcttcctgag 20 889 23 DNA Homo sapiens 889 aaaagggaaa acgtgaccta aag 23 890 20 DNA Homo sapiens 890 ggagaagggg gattctatgc 20 891 20 DNA Homo sapiens 891 accatcatgg aagccaaaag 20 892 22 DNA Homo sapiens 892 gacaataaaa ggcagcttgg ac 22 893 20 DNA Homo sapiens 893 cccatgaact gcctgtcaac 20 894 20 DNA Homo sapiens 894 ccagccctca gagagttcag 20 895 20 DNA Homo sapiens 895 tcgtgtccat gttcacacag 20 896 23 DNA Homo sapiens 896 tgcaggtagt ttgtaaggct ttg 23 897 20 DNA Homo sapiens 897 cgcaggtatg gtatggtcag 20 898 20 DNA Homo sapiens 898 cgcaggtatg gtatggtcag 20 899 22 DNA Homo sapiens 899 aaactgattg tgcagttggt tg 22 900 21 DNA Homo sapiens 900 tgctgaccct tagaagagca c 21 901 23 DNA Homo sapiens 901 ttgaatacat taggggcaat gac 23 902 20 DNA Homo sapiens 902 agcccacgga acaaatgtag 20 903 20 DNA Homo sapiens 903 ctctggaaag ccccaagtct 20 904 20 DNA Homo sapiens 904 tcccaggaca ctctggtttc 20 905 18 DNA Homo sapiens 905 ggccagaggg aagagagg 18 906 20 DNA Homo sapiens 906 gcccgtgaag agattcaaac 20 907 20 DNA Homo sapiens 907 ctccccaagc tgggttaaag 20 908 19 DNA Homo sapiens 908 ctctgccatc agcagcaag 19 909 20 DNA Homo sapiens 909 ttgcactggc ctttatgacc 20 910 21 DNA Homo sapiens 910 caattaccca ggacagagtg c 21 911 21 DNA Homo sapiens 911 ggctgaaagg tgtgtttctt g 21 912 22 DNA Homo sapiens 912 gcaaaccaag ttaatgggaa ag 22 913 21 DNA Homo sapiens 913 gacaactcaa gctgcgaaaa c 21 914 20 DNA Homo sapiens 914 atgacttggg catttgttgc 20 915 20 DNA Homo sapiens 915 ttctgtctca ggggcatagg 20 916 21 DNA Homo sapiens 916 ggcttgtaga ccccttgaat c 21 917 21 DNA Homo sapiens 917 gcagcactgg gtacctgata g 21 918 20 DNA Homo sapiens 918 tggtcctgag ttctgacctg 20 919 18 DNA Homo sapiens 919 ggacaagccc ctgcaaag 18 920 20 DNA Homo sapiens 920 tggaatgaat tctgggttgg 20 921 20 DNA Homo sapiens 921 cagtggcagt gcttagcttg 20 922 18 DNA Homo sapiens 922 ctcttcaggg tcccatgc 18 923 20 DNA Homo sapiens 923 agggagaaca gggctgtatg 20 924 20 DNA Homo sapiens 924 gcatggtggg ctagagtgtg 20 925 21 DNA Homo sapiens 925 tggggtgagg gctataaaaa g 21 926 20 DNA Homo sapiens 926 gctagcactg cagacaggtg 20 927 20 DNA Homo sapiens 927 atctactgcc acacccaagg 20 928 20 DNA Homo sapiens 928 caagccactt tcagcttgtg 20 929 20 DNA Homo sapiens 929 gatagtgcag aggggacagc 20 930 20 DNA Homo sapiens 930 ggacaaagga gagcatcagg 20 931 20 DNA Homo sapiens 931 ggtttggaag aaggggtagg 20 932 19 DNA Homo sapiens 932 cggctgactt cttccactg 19 933 22 DNA Homo sapiens 933 ctgtagttca gggactcaat gg 22 934 20 DNA Homo sapiens 934 tgtcacacct ggaacacagc 20 935 20 DNA Homo sapiens 935 tgtcacacct ggaacacagc 20 936 20 DNA Homo sapiens 936 acaaagtgct ctcggtccag 20 937 19 DNA Homo sapiens 937 tcatggagct caaggatgg 19 938 20 DNA Homo sapiens 938 gcactctgga gcactctgtg 20 939 22 DNA Homo sapiens 939 tgtgcccaca aaaattaaaa ac 22 940 20 DNA Homo sapiens 940 tggtggcatt tacgaatcac 20 941 22 DNA Homo sapiens 941 gaggtacaca tgagctggtt tc 22 942 21 DNA Homo sapiens 942 gctttacaaa cagcggttga c 21 943 21 DNA Homo sapiens 943 caccatcatg aggacacatt c 21 944 22 DNA Homo sapiens 944 tcaccttgca atactgcata cc 22 945 20 DNA Homo sapiens 945 ggcttccacc tgtacctcac 20 946 26 DNA Homo sapiens 946 caatttttgt aaaaagaaca aaatcc 26 947 19 DNA Homo sapiens 947 gtttgggggc tagcttgag 19 948 19 DNA Homo sapiens 948 gtttgggggc tagcttgag 19 949 20 DNA Homo sapiens 949 actgccactt cacccaaaag 20 950 20 DNA Homo sapiens 950 gccagggagc tctgtacctc 20 951 19 DNA Homo sapiens 951 atcggggaga cactcgttc 19 952 20 DNA Homo sapiens 952 cacccacaac accctaaacc 20 953 19 DNA Homo sapiens 953 gagaggggca tgagaggtg 19 954 20 DNA Homo sapiens 954 gtaggaaatg ccagcctgtg 20 955 18 DNA Homo sapiens 955 cacacagagc cctgatcg 18 956 20 DNA Homo sapiens 956 ggggtgtgca ctttatttcc 20 957 18 DNA Homo sapiens 957 ggactcacgg tggcttcc 18 958 20 DNA Homo sapiens 958 cagagaatgg tgcaggtgtg 20 959 23 DNA Homo sapiens 959 tgcaccagat ttctaggaat agc 23 960 20 DNA Homo sapiens 960 ggaggagcac ctagaacagg 20 961 19 DNA Homo sapiens 961 cttgagggtt ggacagcag 19 962 19 DNA Homo sapiens 962 agacagggat gggatctgc 19 963 20 DNA Homo sapiens 963 acttgaccgg gatcttggag 20 964 20 DNA Homo sapiens 964 caagagctgc ctcgattctg 20 965 18 DNA Homo sapiens 965 cttcgagttg gcgctctg 18 966 20 DNA Homo sapiens 966 gtccgcagaa agttcaccag 20 967 20 DNA Homo sapiens 967 tttccccttg atggatcttg 20 968 20 DNA Homo sapiens 968 attatgggcc aagagcttcc 20 969 18 DNA Homo sapiens 969 atgcggtacc ccttctcc 18 970 20 DNA Homo sapiens 970 gggacacaga gacacacagg 20 971 20 DNA Homo sapiens 971 tctcgtgttg catcttcctg 20 972 19 DNA Homo sapiens 972 gtgtgcattt tcccaccag 19 973 20 DNA Homo sapiens 973 agccagtcca tgcttaaagg 20 974 20 DNA Homo sapiens 974 aagggcatgc tgatatttcc 20 975 20 DNA Homo sapiens 975 caatttgctg atgtgcttgg 20 976 20 DNA Homo sapiens 976 taaagggcaa gcatttttgg 20 977 20 DNA Homo sapiens 977 taatgggccc tgtgaaatac 20 978 21 DNA Homo sapiens 978 cacagtcctg gcagatagga g 21 979 21 DNA Homo sapiens 979 aacacagtcc tggcagatag g 21 980 21 DNA Homo sapiens 980 tggacataaa agcctcacac c 21 981 20 DNA Homo sapiens 981 gcccccttcc actacttctg 20 982 20 DNA Homo sapiens 982 ttcaccatca ccaaccactc 20 983 20 DNA Homo sapiens 983 tctggagttc aggcaaggac 20 984 20 DNA Homo sapiens 984 agtgagggaa gggcaagaag 20 985 20 DNA Homo sapiens 985 tagcagcttc caggttacgc 20 986 20 DNA Homo sapiens 986 cctccccaag gaaattcaac 20 987 18 DNA Homo sapiens 987 gggccaggag tgagcttg 18 988 20 DNA Homo sapiens 988 atcaagggga agggagagag 20 989 21 DNA Homo sapiens 989 ccatccctgt gaagctctaa g 21 990 20 DNA Homo sapiens 990 caccgtcaac ctcactttcc 20 991 20 DNA Homo sapiens 991 atgtgacccc accaactttc 20 992 23 DNA Homo sapiens 992 cacgtgcatt atttcacaaa atc 23 993 20 DNA Homo sapiens 993 gccagctgtt gtctcttgtg 20 994 21 DNA Homo sapiens 994 gcataatgca gatgggaaat c 21 995 20 DNA Homo sapiens 995 gaagtgtggc cttgctgaac 20 996 20 DNA Homo sapiens 996 gttgccacct gggatttttc 20 997 20 DNA Homo sapiens 997 gacagagccc ctgctaagtg 20 998 18 DNA Homo sapiens 998 ctcaatggcc aggcatcc

18 999 20 DNA Homo sapiens 999 acccctccct ggactcctac 20 1000 20 DNA Homo sapiens 1000 ggcaacaaga gcaaaactcc 20 1001 19 DNA Homo sapiens 1001 gaggtcatca tgggcagag 19 1002 19 DNA Homo sapiens 1002 attgaggggc agggaagag 19 1003 20 DNA Homo sapiens 1003 cactgctttt cccaagactg 20 1004 19 DNA Homo sapiens 1004 tagatgcctt ccccacctc 19 1005 20 DNA Homo sapiens 1005 cctctctcct agcggcatac 20 1006 18 DNA Homo sapiens 1006 cccccagaca agcagttc 18 1007 20 DNA Homo sapiens 1007 gcagccttct ctccttgaac 20 1008 20 DNA Homo sapiens 1008 agtgaaggga aggcagaacc 20 1009 20 DNA Homo sapiens 1009 agtgaaggga aggcagaacc 20 1010 20 DNA Homo sapiens 1010 gagaaaatgg ttgggctcag 20 1011 20 DNA Homo sapiens 1011 cagccaactc ctcctttttc 20 1012 19 DNA Homo sapiens 1012 tcagggtgca aagtgttgg 19 1013 20 DNA Homo sapiens 1013 agcagcctgt gaacacgtag 20 1014 20 DNA Homo sapiens 1014 agcagcctgt gaacacgtag 20 1015 20 DNA Homo sapiens 1015 tctcagagca accgaagtca 20 1016 18 DNA Homo sapiens 1016 ggtggagacg gtgacctg 18 1017 20 DNA Homo sapiens 1017 actcccacac catcatttcc 20 1018 20 DNA Homo sapiens 1018 ttccaagccc taccaaagag 20 1019 20 DNA Homo sapiens 1019 ctcgcattta tgccaagacc 20 1020 20 DNA Homo sapiens 1020 ccagaagcaa gcagacagag 20 1021 19 DNA Homo sapiens 1021 ctccacggac aggtgagag 19 1022 20 DNA Homo sapiens 1022 tagggccaga cactgggtag 20 1023 19 DNA Homo sapiens 1023 cctcccttct tccagatgc 19 1024 20 DNA Homo sapiens 1024 ctgggggaat tctgagcaag 20 1025 20 DNA Homo sapiens 1025 ccttgggcta ggagaacctc 20 1026 20 DNA Homo sapiens 1026 caggtacacc tgcattgtgg 20 1027 20 DNA Homo sapiens 1027 caggtacacc tgcattgtgg 20 1028 20 DNA Homo sapiens 1028 gtgcaggagg cagagttacc 20 1029 19 DNA Homo sapiens 1029 cccaggaggg agagcattc 19 1030 19 DNA Homo sapiens 1030 gagggagcct cttccttcc 19 1031 19 DNA Homo sapiens 1031 ggtgcagggg aagacaatc 19 1032 20 DNA Homo sapiens 1032 gatgcaagag aggccaaaag 20 1033 19 DNA Homo sapiens 1033 atgcctgcat tcactctgc 19 1034 20 DNA Homo sapiens 1034 tttgccaaac tgccttacag 20 1035 26 DNA Homo sapiens 1035 aaaaggggaa aagaaagaat aacttc 26 1036 20 DNA Homo sapiens 1036 cagatctcag gtcccacacc 20 1037 20 DNA Homo sapiens 1037 gagctcttga ggtccctgtg 20 1038 22 DNA Homo sapiens 1038 ccactacaca atgatgctgg tc 22 1039 23 DNA Homo sapiens 1039 ggcaacttgg ttgaatctta ctg 23 1040 20 DNA Homo sapiens 1040 ggttttccag gaagcatcag 20 1041 21 DNA Homo sapiens 1041 tttggaatga aagaggagca g 21 1042 20 DNA Homo sapiens 1042 atgaaaggtc ctgggttagg 20 1043 22 DNA Homo sapiens 1043 tgccatatca tcatctttag gc 22 1044 24 DNA Homo sapiens 1044 gccttaacct cctaatacct ctgc 24 1045 21 DNA Homo sapiens 1045 caccatcagt tgtcatgttg c 21 1046 20 DNA Homo sapiens 1046 ccaaaaagga ttgcagacag 20 1047 21 DNA Homo sapiens 1047 cccttaaata aacacgcttg c 21 1048 20 DNA Homo sapiens 1048 gcagcaaatg ggacaataag 20 1049 23 DNA Homo sapiens 1049 tcatggttaa tgagacattc tgg 23 1050 20 DNA Homo sapiens 1050 tccactcctg aaccctgaag 20 1051 20 DNA Homo sapiens 1051 cctccagagc catgagaaac 20 1052 20 DNA Homo sapiens 1052 aggctacttg ggaagtgctg 20 1053 19 DNA Homo sapiens 1053 gagcacacta tgcgccatc 19 1054 20 DNA Homo sapiens 1054 ctgcctgtac ttggacttgc 20 1055 20 DNA Homo sapiens 1055 gttttctcca caccctcacg 20 1056 20 DNA Homo sapiens 1056 actctggcag gaaagacagg 20 1057 25 DNA Homo sapiens 1057 aaatgaggga gattttaaga aggag 25 1058 20 DNA Homo sapiens 1058 ttcccagggc acacagtatc 20 1059 20 DNA Homo sapiens 1059 ttcccagggc acacagtatc 20 1060 20 DNA Homo sapiens 1060 ctgcactcct ctggaaactg 20 1061 20 DNA Homo sapiens 1061 gaggcttcca ctcactttgc 20 1062 20 DNA Homo sapiens 1062 gacaaaatag ccccaggatg 20 1063 20 DNA Homo sapiens 1063 cctgggcaca tcaggtattc 20 1064 20 DNA Homo sapiens 1064 atcagaactg ccgaccacac 20 1065 20 DNA Homo sapiens 1065 gtccttcctg tcctcctagc 20 1066 20 DNA Homo sapiens 1066 ttgtggacat aggggtttgc 20 1067 20 DNA Homo sapiens 1067 ggagggcaga agaggaagtc 20 1068 20 DNA Homo sapiens 1068 ggagggcaga agaggaagtc 20 1069 20 DNA Homo sapiens 1069 atcctgggaa gtgcacagac 20 1070 18 DNA Homo sapiens 1070 ctttcatgcc ccttgtgg 18 1071 20 DNA Homo sapiens 1071 gagggtgctc ttagccacag 20 1072 21 DNA Homo sapiens 1072 gaggtaagca gacagccaca c 21 1073 19 DNA Homo sapiens 1073 cagatgcatc gcctaatgc 19 1074 19 DNA Homo sapiens 1074 cgcgagaccc tctcttcag 19 1075 20 DNA Homo sapiens 1075 aatgtgttgc cagcactgag 20 1076 20 DNA Homo sapiens 1076 agcctgggtg acagagtgag 20 1077 19 DNA Homo sapiens 1077 tcgtgagaac aggctgagg 19 1078 20 DNA Homo sapiens 1078 accaggaagt gaaccgaatg 20 1079 19 DNA Homo sapiens 1079 ggccttttag cagctcagg 19 1080 20 DNA Homo sapiens 1080 cacacccacg ctctaaccac 20 1081 19 DNA Homo sapiens 1081 ctgaagagga aggggcaag 19 1082 20 DNA Homo sapiens 1082 actctataca ccgccccttg 20 1083 20 DNA Homo sapiens 1083 atctcctgac ctcgtgatcc 20 1084 19 DNA Homo sapiens 1084 actgcctggt ccagtcctc 19 1085 20 DNA Homo sapiens 1085 ggtttcaagg gcacaaacac 20 1086 21 DNA Homo sapiens 1086 tcctcacgtc ataccaactc c 21 1087 27 DNA Homo sapiens 1087 tttcagacat aacatatttc aatggag 27 1088 21 DNA Homo sapiens 1088 ttggaaagcc tctgttttct g 21 1089 20 DNA Homo sapiens 1089 agttccctct gccctctcac 20 1090 21 DNA Homo sapiens 1090 gcaaaactgc tttttgaaac c 21 1091 22 DNA Homo sapiens 1091 tgagggcaca ttaactgctt ac 22 1092 20 DNA Homo sapiens 1092 tttagacgcc caaccatttc 20 1093 20 DNA Homo sapiens 1093 tgctctgtga atgtcccttg 20 1094 20 DNA Homo sapiens 1094 tgagctcatg tgagggtgag 20 1095 21 DNA Homo sapiens 1095 gggatagctt ccagatgtgt g 21 1096 27 DNA Homo sapiens 1096 tcatctactt tgatgatggt tagtcac 27 1097 20 DNA Homo sapiens 1097 ttataggcat gagccaccag 20 1098 20 DNA Homo sapiens 1098 agagcaggca agaccatgag 20 1099 21 DNA Homo sapiens 1099 caaactattg ggggagagga g 21 1100 27 DNA Homo sapiens 1100 tttagaaaat tgcctaatat caaaaag 27 1101 22 DNA Homo sapiens 1101 aacccttcca aaaacaaaac ag 22 1102 20 DNA Homo sapiens 1102 gtggcttaag cacattttgg 20 1103 20 DNA Homo sapiens 1103 cccccataca catttcaagg 20 1104 20 DNA Homo sapiens 1104 gccctcatca caaggttcac 20 1105 20 DNA Homo sapiens 1105 cccgggtaga aaatgtaagg 20 1106 20 DNA Homo sapiens 1106 ggatcatctc caccacatcc 20 1107 20 DNA Homo sapiens 1107 gggggagaag gagctgtaag 20 1108 24 DNA Homo sapiens 1108 ttgctatctt taaaaacctc caac 24 1109 20 DNA Homo sapiens 1109 tatctcagcg cgtaggacag 20 1110 20 DNA Homo sapiens 1110 ttaaggcact tgcagtggtg 20 1111 20 DNA Homo sapiens 1111 tcacagaaag ccaatgatgg 20 1112 20 DNA Homo sapiens 1112 tgcgtacgcc attactcatc 20 1113 20 DNA Homo sapiens 1113 ctgtcagatg gggagcagag 20 1114 20 DNA Homo sapiens 1114 cccctgacgt acattcaaag 20 1115 24 DNA Homo sapiens 1115 gcatatgggt ggtgatcaac ataa 24 1116 26 DNA Homo sapiens 1116 aaacgctctt aagtttttcc taaatg 26 1117 20 DNA Homo sapiens 1117 agggatgcca aacacatacc 20 1118 27 DNA Homo sapiens 1118 ttgtaccaag atactccata ccctatg 27 1119 22 DNA Homo sapiens 1119 ttttcccacg tggactataa cc 22 1120 21 DNA Homo sapiens 1120 ggtggtggat accctaaaag c 21 1121 21 DNA Homo sapiens 1121 ggtggtggat accctaaaag c 21 1122 22 DNA Homo sapiens 1122 aaaagaaaat gcatgactac cc 22 1123 22 DNA Homo sapiens 1123 caggtctcaa aaagctgagt tg 22 1124 24 DNA Homo sapiens 1124 ccactacata agaggacctt tctc 24 1125 20 DNA Homo sapiens 1125 tccagtccaa gttgatgctg 20 1126 20 DNA Homo sapiens 1126 catgggaata aggggagatg 20 1127 20 DNA Homo sapiens 1127 ggcagtccac agcttctctg 20 1128 18 DNA Homo sapiens 1128 gaaatatggc cgctgacc 18 1129 20 DNA Homo sapiens 1129 ccaggataag gcacttgctc 20 1130 19 DNA Homo sapiens 1130 gcggaaggat gaaaggaac 19 1131 20 DNA Homo sapiens 1131 tgctagagag cagtggaagc 20 1132 25 DNA Homo sapiens 1132 ttaaacagtg accatctatt taccc 25 1133 24 DNA Homo sapiens 1133 gcttgaggga aatatgtaaa tctg 24 1134 23 DNA Homo sapiens 1134 tttcagagtg aatgccagat aac 23 1135 26 DNA Homo sapiens 1135 tctctctaat atggtggaat acaagc 26 1136 23 DNA Homo sapiens 1136 gccaagaaag ttcaaaagaa tcc 23 1137 20 DNA Homo sapiens 1137 ttagcagttc caggcggtag 20 1138 20 DNA Homo sapiens 1138 acccacccat ccaataaatg 20 1139 21 DNA Homo sapiens 1139 ttcagagact gagcaatcgt g 21 1140 21 DNA Homo sapiens 1140 caacctttgc tcaacatacg g 21 1141 20 DNA Homo sapiens 1141 gcacaatatt ggagggtgtc 20 1142 26 DNA Homo sapiens 1142 ctaatttctg acactcagtc tttttg 26 1143 22 DNA Homo sapiens 1143 caaggctctc attttacatt gc 22 1144 20 DNA Homo sapiens 1144 aaaaagcacc ctcaaaatgc 20 1145 24 DNA Homo sapiens 1145 tgtggtagta attgtggaaa actg 24 1146 20 DNA Homo sapiens 1146 cagattccat tcccttaggc 20 1147 21 DNA Homo sapiens 1147 tgcctggtac gcagtaagaa c 21 1148 20 DNA Homo sapiens 1148 aacagcccaa ttctctttgg 20 1149 22 DNA Homo sapiens 1149 caagaccaat tatgaccgat cc 22 1150 19 DNA Homo sapiens 1150 gacaaggagg ccagcagag 19 1151 20 DNA Homo sapiens 1151 ggacccgtgg tgatcattag 20 1152 19 DNA Homo sapiens 1152 gaggtaaggc tgccacctg 19 1153 20 DNA Homo sapiens 1153 ctaccacaga ggccaactcc 20 1154 18 DNA Homo sapiens 1154 aggaggcgag gaggtgag 18 1155 20 DNA Homo sapiens 1155 agcaactggc caggttattc 20 1156 20 DNA Homo sapiens 1156 ctgagacctg ccttccagag 20 1157 20 DNA Homo sapiens 1157 cctggccatg ttcttcaaac 20 1158 20 DNA Homo sapiens 1158 tcacatgcaa tctgatcctg 20 1159 21 DNA Homo sapiens 1159 caagccaact tcttcaactc g 21 1160 20 DNA Homo sapiens 1160 tccagcatcc aaatggttag 20 1161 20 DNA Homo sapiens 1161 tttggtgttt gggatcttcc 20 1162 21 DNA Homo sapiens 1162 gagcacataa ctggtggttc c 21 1163 20 DNA Homo sapiens 1163 tgttacacca cgacccaatg 20 1164 20 DNA Homo sapiens 1164 aaggtgtcca aaccaagctg 20 1165 20 DNA Homo sapiens 1165 ggaatgaaag tgggatcagg 20 1166 20 DNA Homo sapiens 1166 tgagggtgag aggagcagtc 20 1167 20 DNA Homo sapiens 1167 actgggccca atatgacatc 20 1168 20 DNA Homo sapiens 1168 aggatagcgg gactgatgtc 20 1169 21 DNA Homo sapiens 1169 cacccatacg tcttggttca c 21 1170 21 DNA Homo sapiens 1170 ctgtaaccca tgtgaatctg g 21 1171 20 DNA Homo sapiens 1171 cagctgaatc cccacaagtc 20 1172 20 DNA Homo sapiens 1172 atcctgagcc ctaagccaac 20 1173 20 DNA Homo sapiens 1173 gaggagccag tgctgttgag 20 1174 20 DNA Homo sapiens 1174 tatgatgctg ggaccaggtg

20 1175 23 DNA Homo sapiens 1175 ccaatctaca gactgggaaa ctg 23 1176 20 DNA Homo sapiens 1176 gccctcaggc tacagctatc 20 1177 20 DNA Homo sapiens 1177 aggctgccat ctcatattgg 20 1178 20 DNA Homo sapiens 1178 ctctgccagg gtctctatgc 20 1179 20 DNA Homo sapiens 1179 agccaggaca tctttgcatc 20 1180 20 DNA Homo sapiens 1180 catggctctg agacaagcac 20 1181 20 DNA Homo sapiens 1181 attccccttt ccttccagag 20 1182 20 DNA Homo sapiens 1182 gatcacacca tgcactccag 20 1183 20 DNA Homo sapiens 1183 tgactgaggc acaagaatcg 20 1184 25 DNA Homo sapiens 1184 ggaaatgtta actcaccaaa aattc 25 1185 21 DNA Homo sapiens 1185 tgtgccttgt ggcaatataa g 21 1186 27 DNA Homo sapiens 1186 tgcttacccc tactatttca gtaaatc 27 1187 23 DNA Homo sapiens 1187 tgtcatcatg caaaaattct cag 23 1188 23 DNA Homo sapiens 1188 caactagcag aggacacttt cac 23 1189 23 DNA Homo sapiens 1189 caactagcag aggacacttt cac 23 1190 26 DNA Homo sapiens 1190 tgaaattcac ttatttgtgt tgatcc 26 1191 19 DNA Homo sapiens 1191 gtccacgatg gtgtggaag 19 1192 19 DNA Homo sapiens 1192 gggtgcgtac cacttgagc 19 1193 19 DNA Homo sapiens 1193 gacactctgg tgggcactc 19 1194 19 DNA Homo sapiens 1194 aggactttcc aggggtcag 19 1195 19 DNA Homo sapiens 1195 agcctcagcc ttctgtgtg 19 1196 21 DNA Homo sapiens 1196 agtccttcca gaacacaggt c 21 1197 20 DNA Homo sapiens 1197 aagacctccc gtagctgctc 20 1198 20 DNA Homo sapiens 1198 ctgacagcga ccctgatctc 20 1199 19 DNA Homo sapiens 1199 gtgaagccac tcccctctg 19 1200 20 DNA Homo sapiens 1200 tcctctatct gggaatgctg 20 1201 20 DNA Homo sapiens 1201 ttcatgccta caccacttcg 20 1202 19 DNA Homo sapiens 1202 ggctgagagc aaggtcctc 19 1203 20 DNA Homo sapiens 1203 atgggaggta ggagcaaagg 20 1204 18 DNA Homo sapiens 1204 tcaggctgat gggaaagc 18 1205 20 DNA Homo sapiens 1205 gatggaggag gagagctgtg 20 1206 21 DNA Homo sapiens 1206 ttctcaaaat actgccccaa g 21 1207 24 DNA Homo sapiens 1207 gaaatgagga tatggatttt gtcc 24 1208 21 DNA Homo sapiens 1208 tccacagcta agcaatgaca g 21 1209 24 DNA Homo sapiens 1209 ccattaaaca aagtgtcagg tttc 24 1210 23 DNA Homo sapiens 1210 aaaatcccac catttcacta cac 23 1211 22 DNA Homo sapiens 1211 aactatcaga aagccacagc ag 22 1212 21 DNA Homo sapiens 1212 gcctaacatc agacgctcaa c 21 1213 19 DNA Homo sapiens 1213 atgccaccaa agaggaagg 19 1214 20 DNA Homo sapiens 1214 ctaaaggcaa agggaccaag 20 1215 20 DNA Homo sapiens 1215 ttggctctac tgcattccac 20 1216 20 DNA Homo sapiens 1216 tgagtgtgga ggcaatcaag 20 1217 20 DNA Homo sapiens 1217 gcaggaacga gaaaggtcag 20 1218 22 DNA Homo sapiens 1218 aaacactaac aggcaaaagc ag 22 1219 20 DNA Homo sapiens 1219 gctttctcct tgtccagtgc 20 1220 23 DNA Homo sapiens 1220 gtcattcctc ctgtgaggtc tcc 23 1221 20 DNA Homo sapiens 1221 ggttctcccc gtcaaatgtc 20 1222 25 DNA Homo sapiens 1222 ccaatagtag cttttcaaag acagc 25 1223 20 DNA Homo sapiens 1223 cacagccaca tggttacctc 20 1224 20 DNA Homo sapiens 1224 tttggcaaaa tgaaagcatc 20 1225 20 DNA Homo sapiens 1225 ttttccacaa ggggaaagtg 20 1226 19 DNA Homo sapiens 1226 agggatggct ggcttacag 19 1227 20 DNA Homo sapiens 1227 atccccaggg cttacacatc 20 1228 21 DNA Homo sapiens 1228 tgaagaaaac tggaattggt g 21 1229 22 DNA Homo sapiens 1229 aaggcaggca tttctgtaaa ag 22 1230 18 DNA Homo sapiens 1230 cccagaagga ggctggtc 18 1231 20 DNA Homo sapiens 1231 tgggtgaatg acaccatcag 20 1232 20 DNA Homo sapiens 1232 caagctcaag aatgcacagc 20 1233 20 DNA Homo sapiens 1233 acaggaaagg tgagggaagg 20 1234 21 DNA Homo sapiens 1234 tctgaacccc acttgtcttt g 21 1235 21 DNA Homo sapiens 1235 gcatccgtga ctaggagtct g 21 1236 20 DNA Homo sapiens 1236 gtgttcctgg aagcaagtgg 20 1237 19 DNA Homo sapiens 1237 agagctcctg gccagattg 19 1238 18 DNA Homo sapiens 1238 tcccttcccc gtttcctc 18 1239 21 DNA Homo sapiens 1239 aagccattcc tgacctagag c 21 1240 20 DNA Homo sapiens 1240 agctgtggtt cctgtcttcc 20 1241 21 DNA Homo sapiens 1241 ggttcctgtc ttcctgtctc c 21 1242 20 DNA Homo sapiens 1242 caggcccatg atctcagaag 20 1243 20 DNA Homo sapiens 1243 ggaagagcat ttgcctgaag 20 1244 20 DNA Homo sapiens 1244 agagggggtg ctaaggtgac 20 1245 20 DNA Homo sapiens 1245 gcttggagga agaggtgagc 20 1246 20 DNA Homo sapiens 1246 taagaggtca ctggggaacc 20 1247 20 DNA Homo sapiens 1247 gggtatacat tggggtggtc 20 1248 20 DNA Homo sapiens 1248 gcctcagggt gaagagaaac 20 1249 21 DNA Homo sapiens 1249 ggtctcagac acatggacag g 21 1250 20 DNA Homo sapiens 1250 gcggcaatat ccctacagag 20 1251 19 DNA Homo sapiens 1251 cccctgcggt aataactgg 19 1252 19 DNA Homo sapiens 1252 agtgggggaa ccaagtgag 19 1253 20 DNA Homo sapiens 1253 ccatggttgt gaaggacctc 20 1254 21 DNA Homo sapiens 1254 cccacaagac caggatgtta g 21 1255 21 DNA Homo sapiens 1255 aggagtgaat tcagcacatc c 21 1256 18 DNA Homo sapiens 1256 ttgaggccag aggacagc 18 1257 20 DNA Homo sapiens 1257 cctctccccc tcattctctc 20 1258 20 DNA Homo sapiens 1258 tttgagcccc tgactaaagg 20 1259 20 DNA Homo sapiens 1259 tttgagcccc tgactaaagg 20 1260 23 DNA Homo sapiens 1260 gctacattct ggaaaatcac tcg 23 1261 20 DNA Homo sapiens 1261 ttcttgcccc agcaattatg 20 1262 20 DNA Homo sapiens 1262 aggctccatc atgctgtttc 20 1263 24 DNA Homo sapiens 1263 cagatattga ggatatgcac acac 24 1264 26 DNA Homo sapiens 1264 gagtgtaatt attgtggctc cataaa 26 1265 18 DNA Homo sapiens 1265 acccaggcca gcagtacc 18 1266 20 DNA Homo sapiens 1266 ttgaaagaca agcagggatg 20 1267 20 DNA Homo sapiens 1267 ccagagccag tgaatctcag 20 1268 20 DNA Homo sapiens 1268 agaagaacag ggccagagtg 20 1269 20 DNA Homo sapiens 1269 ccagtattcc ggctaaccac 20 1270 20 DNA Homo sapiens 1270 tggtgcccta acctcatctc 20 1271 19 DNA Homo sapiens 1271 ttcactcccc agggtcttc 19 1272 19 DNA Homo sapiens 1272 gatacagggt gggggtgac 19 1273 20 DNA Homo sapiens 1273 agagtaccac gccaaaggac 20 1274 20 DNA Homo sapiens 1274 agagtaccac gccaaaggac 20 1275 20 DNA Homo sapiens 1275 tgggggaggg ttgtaggtag 20 1276 20 DNA Homo sapiens 1276 tgaacattca ggcgtctcag 20 1277 20 DNA Homo sapiens 1277 ttccctgctc ctgttctctg 20 1278 18 DNA Homo sapiens 1278 agggggaggc tgtctttg 18 1279 20 DNA Homo sapiens 1279 ctatctccca gcacccagac 20 1280 20 DNA Homo sapiens 1280 gcgtgaagag gagaaacagg 20 1281 19 DNA Homo sapiens 1281 ccaacagtcg agcatgagc 19 1282 20 DNA Homo sapiens 1282 cagatctggg gcaatactgg 20 1283 20 DNA Homo sapiens 1283 atggatctgg acctgtagcc 20 1284 18 DNA Homo sapiens 1284 agcccctcac gtcctctg 18 1285 18 DNA Homo sapiens 1285 tgtggtggct cacacctg 18 1286 25 DNA Homo sapiens 1286 aaaagtgaca tttcaagtat catgc 25 1287 24 DNA Homo sapiens 1287 tcaagatgtt tgtttaggat ggtg 24 1288 21 DNA Homo sapiens 1288 caggagtgag ggttttgaat g 21 1289 20 DNA Homo sapiens 1289 gcccacagag agtaccttgc 20 1290 22 DNA Homo sapiens 1290 tgtctgtctt caaagggaaa cc 22 1291 20 DNA Homo sapiens 1291 aaccctaccc atccaagagg 20 1292 20 DNA Homo sapiens 1292 attccgaaac tccacacgtc 20 1293 18 DNA Homo sapiens 1293 ggagagtggc ctgtgagc 18 1294 18 DNA Homo sapiens 1294 caggctcggt ggaggaag 18 1295 20 DNA Homo sapiens 1295 gctggtgcct cactcctaac 20 1296 19 DNA Homo sapiens 1296 agttggaagg cctgagtgc 19 1297 19 DNA Homo sapiens 1297 agtgctggcg ttacaggtg 19 1298 20 DNA Homo sapiens 1298 ctttggctct gcaccctaac 20 1299 19 DNA Homo sapiens 1299 atgcaggaaa gcgtgaatg 19 1300 20 DNA Homo sapiens 1300 gtacacccgg tcaaacaagg 20 1301 20 DNA Homo sapiens 1301 gtacacccgg tcaaacaagg 20 1302 20 DNA Homo sapiens 1302 atgggctcct cctggtagtc 20 1303 20 DNA Homo sapiens 1303 gaatgggctc ctcctggtag 20 1304 20 DNA Homo sapiens 1304 ggaggaggag gactggaaag 20 1305 18 DNA Homo sapiens 1305 aggcagaggg aggtggtg 18 1306 20 DNA Homo sapiens 1306 tcacgtcact ggtctgttcc 20 1307 21 DNA Homo sapiens 1307 tcccgtagtt aatggcttct g 21 1308 20 DNA Homo sapiens 1308 tggggacgtt ggactcatac 20 1309 20 DNA Homo sapiens 1309 agcactgtcc catttgaagg 20 1310 20 DNA Homo sapiens 1310 agcactgtcc catttgaagg 20 1311 20 DNA Homo sapiens 1311 ggggagatag gctgataggg 20 1312 20 DNA Homo sapiens 1312 gggactctca tcacctcagc 20 1313 20 DNA Homo sapiens 1313 gcaggaaagc tcaagaaacc 20 1314 18 DNA Homo sapiens 1314 cagctggcct ggatgaag 18 1315 19 DNA Homo sapiens 1315 atcacctgca ggagggaac 19 1316 20 DNA Homo sapiens 1316 ggaggataac ccttctggtc 20 1317 20 DNA Homo sapiens 1317 ggaggataac ccttctggtc 20 1318 20 DNA Homo sapiens 1318 tcagagctga gtcccagagc 20 1319 19 DNA Homo sapiens 1319 agggtgcttg ggaggtatg 19 1320 20 DNA Homo sapiens 1320 catcagttct cccagccaac 20 1321 20 DNA Homo sapiens 1321 tgggatttcc aaaacaaaac 20 1322 20 DNA Homo sapiens 1322 caggtcaagt gcaggaaagg 20 1323 20 DNA Homo sapiens 1323 ctctcttcct gccctgtgag 20 1324 20 DNA Homo sapiens 1324 cccactgctc cctatcactc 20 1325 19 DNA Homo sapiens 1325 gcaaagttgc ctgaaccag 19 1326 20 DNA Homo sapiens 1326 agtgactcat gccagcagac 20 1327 20 DNA Homo sapiens 1327 tcaatgttag tggggccttg 20 1328 20 DNA Homo sapiens 1328 gtgtgaccca tccctactgg 20 1329 20 DNA Homo sapiens 1329 ccccaagcat tatccctcag 20 1330 18 DNA Homo sapiens 1330 ctccacctcc agcacacc 18 1331 20 DNA Homo sapiens 1331 gagagagccc caagtgtgag 20 1332 19 DNA Homo sapiens 1332 cctggaagcg gaggtagtc 19 1333 20 DNA Homo sapiens 1333 gtgaatccac ctctggaagg 20 1334 21 DNA Homo sapiens 1334 ctgaccttcc catctcaaaa g 21 1335 20 DNA Homo sapiens 1335 cagggaggag aaggaagacc 20 1336 22 DNA Homo sapiens 1336 tttttagcag aaataggcaa gc 22 1337 21 DNA Homo sapiens 1337 tggggaggat actggtcttt c 21 1338 22 DNA Homo sapiens 1338 gcctttgtta tccaacactt tg 22 1339 24 DNA Homo sapiens 1339 gaaaatggag tttaagaacc caag 24 1340 20 DNA Homo sapiens 1340 gctaaacagc cattccttgg 20 1341 23 DNA Homo sapiens 1341 aaacaagtca caagtgagca aag 23 1342 23 DNA Homo sapiens 1342 aaacaagtca caagtgagca aag 23 1343 21 DNA Homo sapiens 1343 catgggaggg acttaggttt c 21 1344 21 DNA Homo sapiens 1344 caacagcttg cttctctcag g 21 1345 19 DNA Homo sapiens 1345 atgtgcctga gaccccttc 19 1346 21 DNA Homo sapiens 1346 cgccaggttt tatggaggta g 21 1347 20 DNA Homo sapiens 1347 atcccctacc ctgaacactg 20 1348 20 DNA Homo sapiens 1348 tatgcccctg accatgaaac 20 1349 20 DNA Homo sapiens 1349 tgacccctag gtgtggtctg 20 1350 20 DNA Homo sapiens

1350 tctgagcact agcccacttg 20 1351 21 DNA Homo sapiens 1351 tggtggaaag aagatgtttg g 21 1352 19 DNA Homo sapiens 1352 ctccaatgcc cattcacac 19 1353 20 DNA Homo sapiens 1353 tcctggcatc ttggtctttc 20 1354 20 DNA Homo sapiens 1354 cggttcgtcc ctattttgtg 20 1355 19 DNA Homo sapiens 1355 ctggtccacc accatgaag 19 1356 20 DNA Homo sapiens 1356 gtaacccttc caccttcctg 20 1357 20 DNA Homo sapiens 1357 atgtgggtga tgtgggaaac 20 1358 20 DNA Homo sapiens 1358 cctcgtagaa agggttggag 20 1359 20 DNA Homo sapiens 1359 gaaaaagggg tctcggtctc 20 1360 18 DNA Homo sapiens 1360 gtcacccctg ggtctgtg 18 1361 20 DNA Homo sapiens 1361 tcacattgtc cgtccatttc 20 1362 20 DNA Homo sapiens 1362 tttgcatttt cttcctctgg 20 1363 20 DNA Homo sapiens 1363 tgctttgcat ggtgctactg 20 1364 19 DNA Homo sapiens 1364 cagcactttg ctgggagac 19 1365 20 DNA Homo sapiens 1365 tggatcccac agtgttcatc 20 1366 21 DNA Homo sapiens 1366 tgcctgtaat cccagctact c 21 1367 19 DNA Homo sapiens 1367 cacttttggg aggctgagg 19 1368 20 DNA Homo sapiens 1368 gcctgctgag cctaacattc 20 1369 21 DNA Homo sapiens 1369 ggtgaaggaa gggagaagtt g 21 1370 20 DNA Homo sapiens 1370 gaatttggtg cctgtggaac 20 1371 20 DNA Homo sapiens 1371 gttttcgggg cctttcttac 20 1372 20 DNA Homo sapiens 1372 tacgacaatg catggggaag 20 1373 20 DNA Homo sapiens 1373 cggtgtatgt tcctgcagtc 20 1374 20 DNA Homo sapiens 1374 taatgcttgc tcacctgctg 20 1375 21 DNA Homo sapiens 1375 cccccagagt ttctgcatat c 21 1376 20 DNA Homo sapiens 1376 ggcaaatggt agaaccaagg 20 1377 25 DNA Homo sapiens 1377 tgctttagga aattaggctt atcaa 25 1378 25 DNA Homo sapiens 1378 tgatgatggt gataacatta ttttg 25 1379 20 DNA Homo sapiens 1379 ttgcagtgag tttgccattg 20 1380 21 DNA Homo sapiens 1380 gcacatcttt tgtgggtatg g 21 1381 22 DNA Homo sapiens 1381 ggaaacatgg taagcaaaga cc 22 1382 19 DNA Homo sapiens 1382 aagggcaggc tcaagagtg 19 1383 19 DNA Homo sapiens 1383 gttggggtga gggtgtctc 19 1384 20 DNA Homo sapiens 1384 gcacaacaac tgcagcaaag 20 1385 20 DNA Homo sapiens 1385 aaatggctct ggagggagac 20 1386 20 DNA Homo sapiens 1386 tttcccatag cctgaaaagg 20 1387 21 DNA Homo sapiens 1387 ccactgttgt cgggtgtatt g 21 1388 21 DNA Homo sapiens 1388 aagaagcata tgtggctctg g 21 1389 18 DNA Homo sapiens 1389 acgaaggcct cctcatgc 18 1390 20 DNA Homo sapiens 1390 ctggcacgga ggtagtcttc 20 1391 26 DNA Homo sapiens 1391 aaaccataaa aattcattca aaaagg 26 1392 20 DNA Homo sapiens 1392 ccccacaaag acacacacac 20 1393 22 DNA Homo sapiens 1393 ccagacattc cagatcaaag ac 22 1394 22 DNA Homo sapiens 1394 tgcttcttgc ctcatatttt cc 22 1395 22 DNA Homo sapiens 1395 aaaaggagga cacacaaaaa tc 22 1396 21 DNA Homo sapiens 1396 aaaactcatg ccttcaagct c 21 1397 20 DNA Homo sapiens 1397 ccttcttcct gatggtgtgg 20 1398 27 DNA Homo sapiens 1398 tccttatctt agacacaaaa tgagatg 27 1399 20 DNA Homo sapiens 1399 gccacctgag acagaagagc 20 1400 20 DNA Homo sapiens 1400 taaaaatttc cgggaacagc 20 1401 24 DNA Homo sapiens 1401 aactgctcaa ggaattaatc acag 24 1402 21 DNA Homo sapiens 1402 ggaaaattag ctcatgcaac c 21 1403 23 DNA Homo sapiens 1403 caaaaagatg agccagaaag atg 23 1404 20 DNA Homo sapiens 1404 gtgtcagttt cctgggaagg 20 1405 23 DNA Homo sapiens 1405 cagggcaagt taaatttacc aac 23 1406 25 DNA Homo sapiens 1406 ccacctagtg gagagaatta ctacc 25 1407 20 DNA Homo sapiens 1407 aacttcggct ggtagagtcg 20 1408 20 DNA Homo sapiens 1408 tccatctacc aagcccaatc 20 1409 20 DNA Homo sapiens 1409 tgtgcctgtt tttgtgatgg 20 1410 20 DNA Homo sapiens 1410 tgataggtgc agcaaaccac 20 1411 20 DNA Homo sapiens 1411 caggggcagc tgtagtcaag 20 1412 20 DNA Homo sapiens 1412 taggacactg ccctccctac 20 1413 20 DNA Homo sapiens 1413 tctccctccc tccttcactc 20 1414 18 DNA Homo sapiens 1414 ctatcccagg ccctccag 18 1415 18 DNA Homo sapiens 1415 ctatcccagg ccctccag 18 1416 18 DNA Homo sapiens 1416 ctatcccagg ccctccag 18 1417 20 DNA Homo sapiens 1417 ttgtatctgt gtgcctgctc 20 1418 20 DNA Homo sapiens 1418 gcaagagcag ggaatgaatc 20 1419 24 DNA Homo sapiens 1419 tggaaaaaga aagaagtcaa acac 24 1420 24 DNA Homo sapiens 1420 aaacaggaat cagtgtcaac tttc 24 1421 20 DNA Homo sapiens 1421 gagaggcacc aaagtcacag 20 1422 20 DNA Homo sapiens 1422 tgctgcttta ggcattccac 20 1423 23 DNA Homo sapiens 1423 aaaaactgaa agccaaacaa gag 23 1424 19 DNA Homo sapiens 1424 ttgaaagcca gacgctgtg 19 1425 19 DNA Homo sapiens 1425 acagagggag ctgctttgc 19 1426 20 DNA Homo sapiens 1426 tcgctcccct ttttgattag 20 1427 20 DNA Homo sapiens 1427 cctggtggga ttatgaatgg 20 1428 20 DNA Homo sapiens 1428 aggtctgtct gcctcctgac 20 1429 20 DNA Homo sapiens 1429 gggaggttac agctctcctg 20 1430 19 DNA Homo sapiens 1430 aacaccgctg ctacccaac 19 1431 20 DNA Homo sapiens 1431 tccagcttca caaaggatgg 20 1432 20 DNA Homo sapiens 1432 agccagtgtt ccagcttcac 20 1433 18 DNA Homo sapiens 1433 ggagggaaga gggcattc 18 1434 18 DNA Homo sapiens 1434 gccctttctc tgcacctg 18 1435 20 DNA Homo sapiens 1435 aaccgtatag ccctcaggtg 20 1436 20 DNA Homo sapiens 1436 gtcttcgctc tgggactcac 20 1437 19 DNA Homo sapiens 1437 cgagccacgg atttatgag 19 1438 18 DNA Homo sapiens 1438 gccatgccct agatctgc 18 1439 19 DNA Homo sapiens 1439 gaggcctggt tggtctcag 19 1440 19 DNA Homo sapiens 1440 ctgcagccca gttgtcatc 19 1441 21 DNA Homo sapiens 1441 gcaatttcct tgacaaacag g 21 1442 20 DNA Homo sapiens 1442 cagggtcaga gaggttgctc 20 1443 20 DNA Homo sapiens 1443 acgagtcaca gaggctttgg 20 1444 20 DNA Homo sapiens 1444 ggccacagca aaatagaacc 20 1445 20 DNA Homo sapiens 1445 ttcagcctcc tgtccttgac 20 1446 20 DNA Homo sapiens 1446 acctggcttt gctttgactc 20 1447 20 DNA Homo sapiens 1447 aagttcccgt cctctggttc 20 1448 21 DNA Homo sapiens 1448 tccaaagctc atgttgtttc c 21 1449 20 DNA Homo sapiens 1449 ttcggccttt acagctacag 20 1450 21 DNA Homo sapiens 1450 catacaacca ggcctacaac c 21 1451 20 DNA Homo sapiens 1451 tgacaccagt tgccaaagac 20 1452 19 DNA Homo sapiens 1452 gctgggactt ccaaccttc 19 1453 23 DNA Homo sapiens 1453 gatttaactg tgattgctgg ttg 23 1454 20 DNA Homo sapiens 1454 attgtgtctg gtggatgtgg 20 1455 20 DNA Homo sapiens 1455 ggggcctccg tataattgag 20 1456 20 DNA Homo sapiens 1456 ccaaactccg agtcttcagg 20 1457 20 DNA Homo sapiens 1457 tcaaagtact cgggctccac 20 1458 20 DNA Homo sapiens 1458 tgagggatcc atgacctttc 20 1459 20 DNA Homo sapiens 1459 tatgagccac cacactcagc 20 1460 19 DNA Homo sapiens 1460 gcctcgatgg tgcagatac 19 1461 19 DNA Homo sapiens 1461 gcctcgatgg tgcagatac 19 1462 20 DNA Homo sapiens 1462 ccacccacaa gatgaaggtc 20 1463 21 DNA Homo sapiens 1463 ttccccaact cccattttta c 21 1464 19 DNA Homo sapiens 1464 catgccctgg aaatgtgag 19 1465 20 DNA Homo sapiens 1465 ccctttttca tgggtgaatg 20 1466 20 DNA Homo sapiens 1466 caaagggtgg tgactgaacc 20 1467 20 DNA Homo sapiens 1467 tacagggagg aggtgagtgg 20 1468 20 DNA Homo sapiens 1468 tgagtcgctc aaggtcacac 20 1469 20 DNA Homo sapiens 1469 tcaggaccct cacttgttcc 20 1470 19 DNA Homo sapiens 1470 tcctggaggt ggtggctct 19 1471 20 DNA Homo sapiens 1471 agccgtgaag atgctgaaag 20 1472 22 DNA Homo sapiens 1472 caaaaacatc atcaacctgc tg 22 1473 19 DNA Homo sapiens 1473 aggtgtgggt ggagtaggc 19 1474 21 DNA Homo sapiens 1474 aagaagacaa ccaacgtgag c 21 1475 19 DNA Homo sapiens 1475 ctggcctatt cccctggtg 19 1476 18 DNA Homo sapiens 1476 cagcccttca ggctgttc 18 1477 19 DNA Homo sapiens 1477 ccagagtgct gaggtgtgg 19 1478 19 DNA Homo sapiens 1478 gctggtggaa gtcagaacg 19 1479 22 DNA Homo sapiens 1479 cagttgggaa taggtgacag ag 22 1480 22 DNA Homo sapiens 1480 tctttgaccc agaaaaatag cc 22 1481 24 DNA Homo sapiens 1481 tgtttctgtc agttgacttt tcag 24 1482 26 DNA Homo sapiens 1482 ttttgttttg ttttgtttta ctttgg 26 1483 20 DNA Homo sapiens 1483 tccctgaaag ggaaactcac 20 1484 20 DNA Homo sapiens 1484 attccccctt ttctgctttc 20 1485 22 DNA Homo sapiens 1485 agaccacatt tggttttgat tc 22 1486 20 DNA Homo sapiens 1486 gaaagagtgg cggtgaaagt 20 1487 24 DNA Homo sapiens 1487 tgtttggtaa ttttagaccc agac 24 1488 20 DNA Homo sapiens 1488 ctggcgtgta acaagcactc 20 1489 20 DNA Homo sapiens 1489 gcgcagccca tttttatctc 20 1490 22 DNA Homo sapiens 1490 ccggatacag atacccaaaa ag 22 1491 20 DNA Homo sapiens 1491 gaatgctgtt gtcctgcttg 20 1492 20 DNA Homo sapiens 1492 agaaacatgc cagtcggaag 20 1493 20 DNA Homo sapiens 1493 tgcctatttg aggcaatcag 20 1494 20 DNA Homo sapiens 1494 ttgtggctga ttcaaacgtg 20 1495 20 DNA Homo sapiens 1495 ttacagacgt gagccactgc 20 1496 20 DNA Homo sapiens 1496 gaatccccta cccaggtttg 20 1497 20 DNA Homo sapiens 1497 cacatgggga aaatggagtc 20 1498 20 DNA Homo sapiens 1498 gtcctaggga tgctgctgtc 20 1499 20 DNA Homo sapiens 1499 caggctggga taggataagg 20 1500 18 DNA Homo sapiens 1500 atgtgtggct gggtacgg 18 1501 19 DNA Homo sapiens 1501 gatgtgtggc tgggtacgg 19 1502 19 DNA Homo sapiens 1502 ggtcaagcga gaggaggag 19 1503 20 DNA Homo sapiens 1503 ttttcaaatg gtccctcacc 20 1504 20 DNA Homo sapiens 1504 cgtcccactt cctctgtctc 20 1505 20 DNA Homo sapiens 1505 tacacaccgg aagtgtgagg 20 1506 20 DNA Homo sapiens 1506 ccccagtagg gatttttgtc 20 1507 20 DNA Homo sapiens 1507 actcctaggt cagccccttc 20 1508 20 DNA Homo sapiens 1508 ccctggcttc attctactgg 20 1509 20 DNA Homo sapiens 1509 ccgtgccaag aaaacgtaag 20 1510 18 DNA Homo sapiens 1510 acagagcggg gaaccaac 18 1511 21 DNA Homo sapiens 1511 catttgctgc ttactcattg c 21 1512 20 DNA Homo sapiens 1512 tccttccttt ggtgtgtgtg 20 1513 21 DNA Homo sapiens 1513 ggtttggggc taaaagctat g 21 1514 19 DNA Homo sapiens 1514 gattggtgca ggtgagagc 19 1515 19 DNA Homo sapiens 1515 ctgggcgaca gaacaagac 19 1516 20 DNA Homo sapiens 1516 ctagggggaa aaagcagagg 20 1517 20 DNA Homo sapiens 1517 cctgagctag ggggaaaaag 20 1518 20 DNA Homo sapiens 1518 gctgtggctc ctatcctacc 20 1519 18 DNA Homo sapiens 1519 aaggctgggt tccacctc 18 1520 20 DNA Homo sapiens 1520 gaggctagga ccgtctcagg 20 1521 20 DNA Homo sapiens 1521 cctgtactgg ggacctgttc 20 1522 21 DNA Homo sapiens 1522 ggtcattgca tttaggtcag c 21 1523 22 DNA Homo sapiens 1523 agctcatgcc attaacaatc tc 22 1524 20 DNA Homo sapiens 1524 cagtaccctc tgagcccttg 20 1525 21 DNA Homo sapiens 1525 tcctaaccta cccccttctt g

21 1526 20 DNA Homo sapiens 1526 tgtgataagg ggacctgctc 20 1527 25 DNA Homo sapiens 1527 ttggtgtatt tttagcaggt gtatg 25 1528 20 DNA Homo sapiens 1528 acctggcctc cattataccc 20 1529 22 DNA Homo sapiens 1529 tccttcctct ttgcactatt cc 22 1530 27 DNA Homo sapiens 1530 tggtctagtt catttacaag tgaagac 27 1531 20 DNA Homo sapiens 1531 gaggcaattt ctgagccaac 20 1532 21 DNA Homo sapiens 1532 tggacaaaga tgggtaagtg g 21 1533 20 DNA Homo sapiens 1533 tagtagtggt gtggggcttg 20 1534 20 DNA Homo sapiens 1534 ccattctttc acaaccgatg 20 1535 20 DNA Homo sapiens 1535 tttctcgcct tgttctctgg 20 1536 20 DNA Homo sapiens 1536 tagccattga gcgaatcaac 20 1537 20 DNA Homo sapiens 1537 ttttctcttg ggcttgtgtg 20 1538 20 DNA Homo sapiens 1538 tacctgtagg ggtcgtcctg 20 1539 24 DNA Homo sapiens 1539 atttttcctc tctgtagttt ttgg 24 1540 20 DNA Homo sapiens 1540 ttccttatga tgccctgctc 20 1541 24 DNA Homo sapiens 1541 gcagaccata ataatgaaca cagg 24 1542 20 DNA Homo sapiens 1542 tcagcattcc agaaacatgc 20 1543 20 DNA Homo sapiens 1543 tcaccagaaa gcatgaggag 20 1544 25 DNA Homo sapiens 1544 aagtgctatc ttagggcaaa ttaac 25 1545 27 DNA Homo sapiens 1545 aaaaagaaaa ttcagataag ctctgtg 27 1546 23 DNA Homo sapiens 1546 tttatgtgga agggacattt ttc 23 1547 21 DNA Homo sapiens 1547 ggttatgtgc cctcaactgt g 21 1548 20 DNA Homo sapiens 1548 agagcagtct ggagggtgac 20 1549 20 DNA Homo sapiens 1549 aggtaagtgg gcatgtctgg 20 1550 20 DNA Homo sapiens 1550 ccagagtccc atccaaacac 20 1551 20 DNA Homo sapiens 1551 tcatgctgtt gtctgctgtg 20 1552 20 DNA Homo sapiens 1552 cccttggcat atctgagcac 20 1553 21 DNA Homo sapiens 1553 tgcttgatgt aaaacccttg g 21 1554 20 DNA Homo sapiens 1554 actccaacct catgctccac 20 1555 20 DNA Homo sapiens 1555 agggagggta gatgcaaacc 20 1556 23 DNA Homo sapiens 1556 cagcctagag taagcaggga gtg 23 1557 18 DNA Homo sapiens 1557 agggccctgc cctttaac 18 1558 20 DNA Homo sapiens 1558 cgtttctggg gaagattcag 20 1559 20 DNA Homo sapiens 1559 gggaggtgtg gagaagtgtg 20 1560 18 DNA Homo sapiens 1560 ggaggactgg aggggttg 18 1561 20 DNA Homo sapiens 1561 cagcctggtg acagaatgag 20 1562 22 DNA Homo sapiens 1562 tttttgcttt tgatttcgat tc 22 1563 24 DNA Homo sapiens 1563 tgaaaacagc attattgttg aatg 24 1564 24 DNA Homo sapiens 1564 tctttcaaag tgcctattgg tatg 24 1565 20 DNA Homo sapiens 1565 tacctcccag ctggtactcg 20 1566 20 DNA Homo sapiens 1566 actcagggtg gggtctagtg 20 1567 21 DNA Homo sapiens 1567 tttcctttgt gtgtgaagca g 21 1568 24 DNA Homo sapiens 1568 tgctgttttg cttatctttt cttg 24 1569 24 DNA Homo sapiens 1569 tggatgatca agaaatacgt caag 24 1570 22 DNA Homo sapiens 1570 tggtccataa cccacatagt tg 22 1571 17 DNA Homo sapiens 1571 cttagctagc gccgccg 17 1572 20 DNA Homo sapiens 1572 acaacttgcc gtgtttaccc 20 1573 21 DNA Homo sapiens 1573 aggaggatgg cagaagagtt c 21 1574 20 DNA Homo sapiens 1574 atctgttggg gagaatgtgg 20 1575 21 DNA Homo sapiens 1575 gctctccagg tcaccataag c 21 1576 21 DNA Homo sapiens 1576 tcaaggatgc tgaggaatgt c 21 1577 24 DNA Homo sapiens 1577 tcctttctaa aatgacccta cctg 24 1578 23 DNA Homo sapiens 1578 caaatgtgta aagttggtgt tgc 23 1579 20 DNA Homo sapiens 1579 tctccattaa cccactgagc 20 1580 22 DNA Homo sapiens 1580 ggggttttga aggaaactat tg 22 1581 27 DNA Homo sapiens 1581 tacatgcata tgcatataca tgtatcc 27 1582 22 DNA Homo sapiens 1582 gggctacttc tttgatttct gg 22 1583 23 DNA Homo sapiens 1583 agggctactt ctttgatttc tgg 23 1584 20 DNA Homo sapiens 1584 tagccccagg aaaaatgttg 20 1585 20 DNA Homo sapiens 1585 tgagactcat ggctgggttc 20 1586 20 DNA Homo sapiens 1586 gatcttggct cactgcaacc 20 1587 20 DNA Homo sapiens 1587 actgaccttt tggcccaatc 20 1588 20 DNA Homo sapiens 1588 gggcaacaga gtgagactcc 20 1589 26 DNA Homo sapiens 1589 aaaattagat atttgtccct cagttg 26 1590 23 DNA Homo sapiens 1590 tgaaacgtaa tggcttaatc aac 23 1591 19 DNA Homo sapiens 1591 ggcggtgtct agtgacagg 19 1592 20 DNA Homo sapiens 1592 acctatctgg aagccgaagc 20 1593 19 DNA Homo sapiens 1593 gagttggagg gtggagcag 19 1594 18 DNA Homo sapiens 1594 cagcctggct ctggaaag 18 1595 20 DNA Homo sapiens 1595 acagggggtc acaacaagtg 20 1596 18 DNA Homo sapiens 1596 gctgtggatg ggctggag 18 1597 19 DNA Homo sapiens 1597 aggtgaggga caggtcagc 19 1598 18 DNA Homo sapiens 1598 agctccatcc cccttctg 18 1599 20 DNA Homo sapiens 1599 tccagtcact gtgctgcttc 20 1600 19 DNA Homo sapiens 1600 ctggctacgg tgcagaaag 19 1601 24 DNA Homo sapiens 1601 ttttatcttt tgaaaacaat ggtg 24 1602 19 DNA Homo sapiens 1602 caccatggat cagccagtc 19 1603 20 DNA Homo sapiens 1603 attaagagcc caaggggaac 20 1604 19 DNA Homo sapiens 1604 tgtgagctcc ttccccatc 19 1605 27 DNA Homo sapiens 1605 aatggtaagt tctgagtgtc tctattc 27 1606 20 DNA Homo sapiens 1606 ccaaatttga atgccaaagg 20 1607 20 DNA Homo sapiens 1607 aggggatgag gaggtagagc 20 1608 21 DNA Homo sapiens 1608 tcattcatta ccagcctttg g 21 1609 26 DNA Homo sapiens 1609 tgatttttat ttttgggtgt actgaa 26 1610 20 DNA Homo sapiens 1610 ccacatttca gcaacagcag 20 1611 20 DNA Homo sapiens 1611 tgatccttgc caaagacaac 20 1612 20 DNA Homo sapiens 1612 gctggatgcc catacatttg 20 1613 25 DNA Homo sapiens 1613 tttccatcag ttagttgtga tcttg 25 1614 20 DNA Homo sapiens 1614 tgctcaagcg taagttcctg 20 1615 21 DNA Homo sapiens 1615 cacccttggg tatttttatg g 21 1616 20 DNA Homo sapiens 1616 aagttgcctg gtgaaggaag 20 1617 20 DNA Homo sapiens 1617 tatcttgcca ggctttttcc 20 1618 27 DNA Homo sapiens 1618 cactgatagc tcatacattc aaaattc 27 1619 25 DNA Homo sapiens 1619 tgaagcagat tatagatgaa tgagg 25 1620 26 DNA Homo sapiens 1620 tctctctaaa ttttgaagtg aagcag 26 1621 23 DNA Homo sapiens 1621 cagaccttaa atctttgcca aag 23 1622 20 DNA Homo sapiens 1622 cggattcctt gcaatgtgtg 20 1623 20 DNA Homo sapiens 1623 actgctggct agaggagagc 20 1624 24 DNA Homo sapiens 1624 gaggtggttc attttaaact atgc 24 1625 21 DNA Homo sapiens 1625 ccacgttttt cctctctttc a 21 1626 20 DNA Homo sapiens 1626 tctgaggccg agtagtgtcc 20 1627 20 DNA Homo sapiens 1627 gggggtagga agagatgacc 20 1628 20 DNA Homo sapiens 1628 tcattggctc actgttctgg 20 1629 20 DNA Homo sapiens 1629 attggcaatt ccacctgacc 20 1630 20 DNA Homo sapiens 1630 ctgccatgtg ctgctttaac 20 1631 18 DNA Homo sapiens 1631 acggctgtga ggagcaag 18 1632 20 DNA Homo sapiens 1632 ctcatatcct gtgcccttgc 20 1633 26 DNA Homo sapiens 1633 tgtcagtgat atgtgaatga aatgac 26 1634 22 DNA Homo sapiens 1634 aaccgaagag gtgatttttc ag 22 1635 24 DNA Homo sapiens 1635 gaaatttcac cttaatctgt ttgg 24 1636 27 DNA Homo sapiens 1636 ctagtcttta aggaaaagtc attgcat 27 1637 20 DNA Homo sapiens 1637 atcctgcact tccacactcc 20 1638 20 DNA Homo sapiens 1638 atgatggagt ggaggtggag 20 1639 20 DNA Homo sapiens 1639 gccagattgg atgggtagtg 20 1640 20 DNA Homo sapiens 1640 gagctaggct tgcacagagg 20 1641 20 DNA Homo sapiens 1641 ggaggaggtg cagatgtgtc 20 1642 20 DNA Homo sapiens 1642 acccatgaac ctgggtattg 20 1643 20 DNA Homo sapiens 1643 ctctaaaatg cccccagtcc 20 1644 20 DNA Homo sapiens 1644 ggcctccttt aagggtcttg 20 1645 20 DNA Homo sapiens 1645 ctgacctggt atggtcatgg 20 1646 20 DNA Homo sapiens 1646 gtccaccccc ttactcattg 20 1647 19 DNA Homo sapiens 1647 ctggtcacac caggctgag 19 1648 20 DNA Homo sapiens 1648 ctgaaagctc agggataggg 20 1649 20 DNA Homo sapiens 1649 gtggtggggg tggatatctg 20 1650 18 DNA Homo sapiens 1650 tgtggtgggc tgtccttc 18 1651 20 DNA Homo sapiens 1651 aggtggagac acagccagag 20 1652 20 DNA Homo sapiens 1652 actgaaacct cctcgtgtgc 20 1653 20 DNA Homo sapiens 1653 gcttcctcca gcaattgacc 20 1654 20 DNA Homo sapiens 1654 tcctccttca tccctgtctg 20 1655 20 DNA Homo sapiens 1655 gggtacccac gaagactgac 20 1656 20 DNA Homo sapiens 1656 cctcaccctt agggcttgtg 20 1657 20 DNA Homo sapiens 1657 cctcaccctt agggcttgtg 20 1658 20 DNA Homo sapiens 1658 catcttgggc aggtagaagc 20 1659 20 DNA Homo sapiens 1659 tgggagatag tgagccttgg 20 1660 20 DNA Homo sapiens 1660 cctcagcttt gatccctgtg 20 1661 20 DNA Homo sapiens 1661 ccccaaggag aaaaagaagc 20 1662 25 DNA Homo sapiens 1662 ttgtgtaaga atccgtttta gttcc 25 1663 20 DNA Homo sapiens 1663 tcccctgaag aagtgattcg 20 1664 23 DNA Homo sapiens 1664 caggctacct agaattgaac acg 23 1665 21 DNA Homo sapiens 1665 aggattcttt ctgagggaag g 21 1666 20 DNA Homo sapiens 1666 ggattctttc tgagggaagg 20 1667 20 DNA Homo sapiens 1667 tgggtacacc atgctttttg 20 1668 26 DNA Homo sapiens 1668 tcagtatcca gaatgagcat tacttc 26 1669 20 DNA Homo sapiens 1669 gcgtcatctg atgctgtttc 20 1670 20 DNA Homo sapiens 1670 tcatctgatg ctgtttcctg 20 1671 20 DNA Homo sapiens 1671 gatgagtttg ctcccagctc 20 1672 20 DNA Homo sapiens 1672 tggctcctag ttgcttttgg 20 1673 20 DNA Homo sapiens 1673 agggcaggtg aggtacagag 20 1674 20 DNA Homo sapiens 1674 agcgttggaa cgagtgtctc 20 1675 19 DNA Homo sapiens 1675 ctatgtggcc tgggagctg 19 1676 20 DNA Homo sapiens 1676 aactgtgggg acccagaaac 20 1677 20 DNA Homo sapiens 1677 ctaaatccag gctccctgtg 20 1678 19 DNA Homo sapiens 1678 gtgatggctg ctgtgtgtg 19 1679 20 DNA Homo sapiens 1679 agagcttgga ggcagatgag 20 1680 18 DNA Homo sapiens 1680 atcaccgtcc cactgctg 18 1681 18 DNA Homo sapiens 1681 gatggctggt gtggcttc 18 1682 20 DNA Homo sapiens 1682 ctgagccaga ccccttagtg 20 1683 18 DNA Homo sapiens 1683 gtgtgtgctg gggacagg 18 1684 19 DNA Homo sapiens 1684 ctgctgtcca accctcaag 19 1685 19 DNA Homo sapiens 1685 gaaggtgacg tgggtggac 19 1686 18 DNA Homo sapiens 1686 aaggtcagcg gaggctct 18 1687 18 DNA Homo sapiens 1687 caagggcagg cagatgac 18 1688 19 DNA Homo sapiens 1688 aggccttcct ggacgagac 19 1689 20 DNA Homo sapiens 1689 attgtcatgg agcacgtgag 20 1690 20 DNA Homo sapiens 1690 gaggctttgt gagcttgtgg 20 1691 20 DNA Homo sapiens 1691 agtgagggtc aacccaggag 20 1692 20 DNA Homo sapiens 1692 ggctccgtac cctaaaatgg 20 1693 21 DNA Homo sapiens 1693 tgtccgtctg tctctctgtc c 21 1694 21 DNA Homo sapiens 1694 tcataatgca gcctcggtaa c 21 1695 24 DNA Homo sapiens 1695 tttgacagta cactgcttca gttg 24 1696 20 DNA Homo sapiens 1696 agcctgggtg acagaacaag 20 1697 21 DNA Homo sapiens 1697 tgggtgacag aacaagactc c 21 1698 22 DNA Homo sapiens 1698 gctgaagctt taggattgtg ag 22 1699 22 DNA Homo sapiens 1699 aaattattct tggccaaagt gg 22 1700 23 DNA Homo sapiens 1700 tctgcctata acacaaaacc aag 23 1701 24 DNA Homo sapiens 1701 ctctgcctat aacacaaaac caag

24 1702 21 DNA Homo sapiens 1702 ctcagttgtg tgccttttct g 21 1703 20 DNA Homo sapiens 1703 tgtaatggtg aggccacaag 20 1704 22 DNA Homo sapiens 1704 ccacctcaga agtagtggaa gg 22 1705 18 DNA Homo sapiens 1705 aagggccagt ggcttctc 18 1706 20 DNA Homo sapiens 1706 tgagtcacca ctgtgggaag 20 1707 22 DNA Homo sapiens 1707 cccccataaa ttacttgctt tg 22 1708 20 DNA Homo sapiens 1708 aggtagtgca aggcgtaacc 20 1709 20 DNA Homo sapiens 1709 gaaggcacca gtgagtaggg 20 1710 20 DNA Homo sapiens 1710 acctgagcat accagggttc 20 1711 20 DNA Homo sapiens 1711 agcctctcag cctttgacag 20 1712 25 DNA Homo sapiens 1712 tctagtgaga cacacaaaca aactg 25 1713 25 DNA Homo sapiens 1713 tctgaaacaa aacacatttt attgg 25 1714 24 DNA Homo sapiens 1714 tccaatttgt tcctgatcct aagg 24 1715 20 DNA Homo sapiens 1715 tgtgaccatc tgctgaaatg 20 1716 20 DNA Homo sapiens 1716 agagcaaaag caggttggag 20 1717 20 DNA Homo sapiens 1717 caggggagtg aatcaactgg 20 1718 21 DNA Homo sapiens 1718 cttgccttaa tcactcccat c 21 1719 18 DNA Homo sapiens 1719 gcagcggtgg tgacacag 18 1720 20 DNA Homo sapiens 1720 ctacacctgt gcccaccttc 20 1721 19 DNA Homo sapiens 1721 ccttcgggta aggatgtgg 19 1722 19 DNA Homo sapiens 1722 tcaggaggca gaacacctg 19 1723 18 DNA Homo sapiens 1723 cctgcccacc tccatagg 18 1724 20 DNA Homo sapiens 1724 tcatccaggt tagggagcag 20 1725 19 DNA Homo sapiens 1725 accgagtcct gtccccacc 19 1726 20 DNA Homo sapiens 1726 tttcagctgt gctgcttttg 20 1727 20 DNA Homo sapiens 1727 attctggaga ggtggggaag 20 1728 24 DNA Homo sapiens 1728 gctactatgt tagccagaat gttg 24 1729 20 DNA Homo sapiens 1729 aaaaaggttg gggaccactg 20 1730 18 DNA Homo sapiens 1730 gcgacagagc gagactcc 18 1731 18 DNA Homo sapiens 1731 gcgacagagc gagactcc 18 1732 20 DNA Homo sapiens 1732 ttctgccttc ccttcacttc 20 1733 21 DNA Homo sapiens 1733 gctgggatta taggtgtgag c 21 1734 21 DNA Homo sapiens 1734 agggagtagg aggtgctaag g 21 1735 22 DNA Homo sapiens 1735 ttggagacat tattgcaaga gc 22 1736 23 DNA Homo sapiens 1736 cttggagaca ttattgcaag agc 23 1737 20 DNA Homo sapiens 1737 gctgagctca acgtagcaag 20 1738 19 DNA Homo sapiens 1738 cactgggggt ggacaagac 19 1739 19 DNA Homo sapiens 1739 cctctggcgg tatctgagg 19 1740 19 DNA Homo sapiens 1740 ggtgctggtt ctggctctc 19 1741 20 DNA Homo sapiens 1741 agcctggtga gagctaggtg 20 1742 19 DNA Homo sapiens 1742 ctgggaggat gacatgcag 19 1743 20 DNA Homo sapiens 1743 tgtgtgtgca tgtgtgtgtg 20 1744 20 DNA Homo sapiens 1744 ctcactcaac cgggagacac 20 1745 20 DNA Homo sapiens 1745 cccctagcca ggaaccttag 20 1746 18 DNA Homo sapiens 1746 cctggtctgc ctgaggtg 18 1747 20 DNA Homo sapiens 1747 gtgggctctc tctcctctcc 20 1748 20 DNA Homo sapiens 1748 ggatctgggg cttccaatag 20 1749 19 DNA Homo sapiens 1749 ctgagtggag cccagagtg 19 1750 20 DNA Homo sapiens 1750 gaaggggcag agttgtcatc 20 1751 20 DNA Homo sapiens 1751 ggaacagtag ttgggggttg 20 1752 21 DNA Homo sapiens 1752 aggctcagaa ccaagttctc c 21 1753 20 DNA Homo sapiens 1753 tggtaaccca gtggtgtgtg 20 1754 20 DNA Homo sapiens 1754 atttctgtgg ggcattccag 20 1755 23 DNA Homo sapiens 1755 gcatctatgt gtgaagagtg cag 23 1756 20 DNA Homo sapiens 1756 gggaagttgt tgctttttgc 20 1757 23 DNA Homo sapiens 1757 tgaaattgca taacatcttc agg 23 1758 21 DNA Homo sapiens 1758 tccagattgc ctttctgtct g 21 1759 18 DNA Homo sapiens 1759 cccattgagc tggacacc 18 1760 18 DNA Homo sapiens 1760 gtgtcagggg ccaccatc 18 1761 19 DNA Homo sapiens 1761 caggcatctc accatgctc 19 1762 20 DNA Homo sapiens 1762 tttggaccct gcttgaactc 20 1763 20 DNA Homo sapiens 1763 accaacccaa gtggatgaag 20 1764 20 DNA Homo sapiens 1764 tgtgaggaga ggagacatgc 20 1765 21 DNA Homo sapiens 1765 ttgtgaggag aggagacatg c 21 1766 21 DNA Homo sapiens 1766 ggggccttga gaattaacat c 21 1767 22 DNA Homo sapiens 1767 tgcccaactt tatttctttt cc 22 1768 20 DNA Homo sapiens 1768 ggactgcctc tccttgtctg 20 1769 20 DNA Homo sapiens 1769 cttcattgcc tttttcatgg 20 1770 28 DNA Homo sapiens 1770 actactctgt gaatatacta aaacccac 28 1771 20 DNA Homo sapiens 1771 gcctggaagc tcaggtacag 20 1772 21 DNA Homo sapiens 1772 ggctgttttc tcatcttttg c 21 1773 19 DNA Homo sapiens 1773 gtgggggtga ggagcttag 19 1774 19 DNA Homo sapiens 1774 aaacagtgtc ccccagcag 19 1775 20 DNA Homo sapiens 1775 aaaagccctc tcttctgctg 20 1776 21 DNA Homo sapiens 1776 tgtgtcttct cccacatacg g 21 1777 20 DNA Homo sapiens 1777 ttttcatctg gtgtggatgc 20 1778 21 DNA Homo sapiens 1778 ttgatggtga ctgagggtag c 21 1779 20 DNA Homo sapiens 1779 ggcaatttcc acagcacatc 20 1780 20 DNA Homo sapiens 1780 ttctttcctg ttccccaaag 20 1781 21 DNA Homo sapiens 1781 cctgttcccc aaagttttca g 21 1782 19 DNA Homo sapiens 1782 ttgtggagcc acagctcag 19 1783 20 DNA Homo sapiens 1783 tctcagaaag ggtgggtctc 20 1784 21 DNA Homo sapiens 1784 ttgccatacc atgtcttcct c 21 1785 20 DNA Homo sapiens 1785 ttgggtggct tcattctctc 20 1786 19 DNA Homo sapiens 1786 gagactgctg caggaaacg 19 1787 20 DNA Homo sapiens 1787 agggtggtga aggatgtttg 20 1788 20 DNA Homo sapiens 1788 gctgtggttt gtgatggttg 20 1789 20 DNA Homo sapiens 1789 tatgtccaca aggggctagg 20 1790 20 DNA Homo sapiens 1790 taggatgggg actcttgctg 20 1791 20 DNA Homo sapiens 1791 tagcccatgg gagaactctg 20 1792 20 DNA Homo sapiens 1792 ctcctgagca gaacctctgg 20 1793 18 DNA Homo sapiens 1793 agactggagg gggagtgg 18 1794 20 DNA Homo sapiens 1794 tgggaaggag agatgagtcc 20 1795 20 DNA Homo sapiens 1795 ttaaggctca gccaaactgg 20 1796 20 DNA Homo sapiens 1796 aggacgagta tgcgctgaag 20 1797 21 DNA Homo sapiens 1797 tgaggagcag agtcagaatc c 21 1798 20 DNA Homo sapiens 1798 ttccattgtc agcattgcac 20 1799 20 DNA Homo sapiens 1799 atcccttctg aggtctgctg 20 1800 21 DNA Homo sapiens 1800 caggattgga atgttgcttt c 21 1801 20 DNA Homo sapiens 1801 agaatcggat cctggggtag 20 1802 20 DNA Homo sapiens 1802 ggtattccga aaggatctgc 20 1803 20 DNA Homo sapiens 1803 ctctgctggg ctcaaggtag 20 1804 18 DNA Homo sapiens 1804 ctcctggctg ctcaggtc 18 1805 20 DNA Homo sapiens 1805 gtctcaggtg agggcttcag 20 1806 20 DNA Homo sapiens 1806 ccctgtgagg tgagacttcc 20 1807 24 DNA Homo sapiens 1807 ttgcatttct tagcactcac tctc 24 1808 29 DNA Homo sapiens 1808 acctgataca taaatatgtt cttatcatg 29 1809 27 DNA Homo sapiens 1809 tttcattact cttaaatgcc atatttc 27 1810 20 DNA Homo sapiens 1810 ccttttacac aggggaggtg 20 1811 20 DNA Homo sapiens 1811 ggcctatggt gacctcaatg 20 1812 20 DNA Homo sapiens 1812 gtgaggagca tggttgtttg 20 1813 20 DNA Homo sapiens 1813 tcccaaagtg ctgggattac 20 1814 21 DNA Homo sapiens 1814 ctccttcatg tcttggagtg g 21 1815 26 DNA Homo sapiens 1815 tgcaaaagtt aaactgtgat tattgg 26 1816 22 DNA Homo sapiens 1816 agatcatgtt cttggaagga tg 22 1817 20 DNA Homo sapiens 1817 caggtatttc cgtgggactg 20 1818 22 DNA Homo sapiens 1818 gggtcactca ttagtgccta tc 22 1819 21 DNA Homo sapiens 1819 gcagtgtgtg actcaggatt g 21 1820 20 DNA Homo sapiens 1820 tttgggttgg gagaagagac 20 1821 24 DNA Homo sapiens 1821 gaaatgtctg aaaggaggtt catc 24 1822 22 DNA Homo sapiens 1822 caggtgatct tttaatgcct tg 22 1823 26 DNA Homo sapiens 1823 tgtcatttaa aaagaaaatt tacacg 26 1824 27 DNA Homo sapiens 1824 atgtcattta aaaagaaaat ttacacg 27 1825 19 DNA Homo sapiens 1825 ggtggggact ggatgaatg 19 1826 20 DNA Homo sapiens 1826 tagtttgggc atgtgtaggc 20 1827 20 DNA Homo sapiens 1827 gaagattttg gctggaggtg 20 1828 18 DNA Homo sapiens 1828 gcagcaccga tgatgacc 18 1829 20 DNA Homo sapiens 1829 aaacaaggag ggcaagaatg 20 1830 20 DNA Homo sapiens 1830 gctggttggt ttgaggtttc 20 1831 20 DNA Homo sapiens 1831 cagttgaggg actggtttcc 20 1832 23 DNA Homo sapiens 1832 tgttggtttg ttttatgttt tgc 23 1833 21 DNA Homo sapiens 1833 cacagcatgt gaaatggatt c 21 1834 21 DNA Homo sapiens 1834 ccgtatgtta tctgggaggt g 21 1835 20 DNA Homo sapiens 1835 tgaattgtcc cctcttggtc 20 1836 20 DNA Homo sapiens 1836 tgacagccct ccctttgtag 20 1837 22 DNA Homo sapiens 1837 caaccaagat tgtgcaaatg ac 22 1838 24 DNA Homo sapiens 1838 cgattatttt ggtcaacttg aatg 24 1839 25 DNA Homo sapiens 1839 aagacagtct gctaattcca gctac 25 1840 33 DNA Homo sapiens 1840 ataaagtttt gtcatcttag atttcatata tgt 33 1841 27 DNA Homo sapiens 1841 ataaagggaa tatatagggt taagacc 27 1842 24 DNA Homo sapiens 1842 aaaataggcc tgattattca aatg 24 1843 21 DNA Homo sapiens 1843 aggcctgctg tgataactct t 21 1844 22 DNA Homo sapiens 1844 ccattgactg gaggaaattg ag 22 1845 22 DNA Homo sapiens 1845 ttatgacatg tgccctgtat tg 22 1846 20 DNA Homo sapiens 1846 tgcttccact gctctctagc 20 1847 26 DNA Homo sapiens 1847 aagagaaagg tcctcttatg tagtgg 26 1848 20 DNA Homo sapiens 1848 caggggtggg aaggatagac 20 1849 20 DNA Homo sapiens 1849 agctagccag tgcccatctc 20 1850 20 DNA Homo sapiens 1850 tatagggatg agcccaggtg 20 1851 20 DNA Homo sapiens 1851 acctcagccc caaaggtaag 20 1852 20 DNA Homo sapiens 1852 aacagttgca gcttcaggag 20 1853 20 DNA Homo sapiens 1853 gatagcccct gcactaccac 20 1854 27 DNA Homo sapiens 1854 gtcagtcttg ttacaaaatt caatatg 27 1855 21 DNA Homo sapiens 1855 tgagaaattc tgtccggttt c 21 1856 19 DNA Homo sapiens 1856 cgcccatgaa aacgtaaac 19 1857 20 DNA Homo sapiens 1857 ccgcccatga aaacgtaaac 20 1858 20 DNA Homo sapiens 1858 ttcctgccga tgttagtgtc 20 1859 21 DNA Homo sapiens 1859 gttcctgccg atgttagtgt c 21 1860 24 DNA Homo sapiens 1860 tgcaaattgt gctaattgaa aatc 24 1861 19 DNA Homo sapiens 1861 tgcaccttat ggggtaggg 19 1862 24 DNA Homo sapiens 1862 caaaggcaca aatattttaa atgg 24 1863 27 DNA Homo sapiens 1863 tctctataat cctcaggtaa atccaac 27 1864 25 DNA Homo sapiens 1864 gaaaaataat tcaacgcatt tactc 25 1865 21 DNA Homo sapiens 1865 catgtgtttt attgggggat g 21 1866 21 DNA Homo sapiens 1866 gcacgcagat atttttcatg g 21 1867 21 DNA Homo sapiens 1867 gatgctgctg aactaccaac c 21 1868 20 DNA Homo sapiens 1868 tgtgcctcat tcttctctgg 20 1869 22 DNA Homo sapiens 1869 ttttatatgg gccaaaacat tc 22 1870 24 DNA Homo sapiens 1870 aaacagttga tgacagttta gtgc 24 1871 26 DNA Homo sapiens 1871 ttaaacagtt gatgacagtt tagtgc 26 1872 19 DNA Homo sapiens 1872 atggaggaca cagcccttc 19 1873 20 DNA Homo sapiens 1873 caggggtagg aagcagaatg 20 1874 19 DNA Homo sapiens 1874 cttggaggcc aagctcttc 19 1875 18 DNA Homo sapiens 1875 agcttgtgca gggtgagc 18 1876 20 DNA Homo sapiens 1876 gcttttgtcc ttggctttcc 20 1877 20 DNA Homo sapiens 1877

tccctgtcta ccctggactc 20 1878 20 DNA Homo sapiens 1878 tcatggtatc ccccagagtc 20 1879 20 DNA Homo sapiens 1879 tagcttgcca agtgcctttc 20 1880 20 DNA Homo sapiens 1880 cacatgcaga cgcaaagaag 20 1881 20 DNA Homo sapiens 1881 gaggagaggg gaattcatgg 20 1882 20 DNA Homo sapiens 1882 atgtgtgtgt gcatccttgg 20 1883 19 DNA Homo sapiens 1883 gccgctagtg tgggtttac 19 1884 22 DNA Homo sapiens 1884 caaatagctg gtggtcaaaa cc 22 1885 24 DNA Homo sapiens 1885 aagaaaacca aatacagctc tctg 24 1886 20 DNA Homo sapiens 1886 tgcagggtaa cttgatgtgc 20 1887 20 DNA Homo sapiens 1887 caagtgggtt ttgaaggatg 20 1888 20 DNA Homo sapiens 1888 agttcctgga ggtggaggag 20 1889 20 DNA Homo sapiens 1889 aagggcagac tgacatccag 20 1890 20 DNA Homo sapiens 1890 tatgcagatg gaggttgcac 20 1891 19 DNA Homo sapiens 1891 agctgggcaa ggtaaggtg 19 1892 19 DNA Homo sapiens 1892 acagctgggc aaggtaagg 19 1893 20 DNA Homo sapiens 1893 gcaaaactga ggtcgagagg 20 1894 20 DNA Homo sapiens 1894 gaggtcgaga gggacacaag 20 1895 20 DNA Homo sapiens 1895 atagttgggg tctgggttgg 20 1896 20 DNA Homo sapiens 1896 cacctaccct gaccagttcc 20 1897 19 DNA Homo sapiens 1897 atcacagatg gcccctacc 19 1898 20 DNA Homo sapiens 1898 gtcacttggg aggaaggttg 20 1899 20 DNA Homo sapiens 1899 tgggaagcct aggacatctg 20 1900 20 DNA Homo sapiens 1900 ctagagatgg gacccagcag 20 1901 20 DNA Homo sapiens 1901 tccagtgatt ctggggacag 20 1902 20 DNA Homo sapiens 1902 ctatgcatgg gggtagcttg 20 1903 20 DNA Homo sapiens 1903 ccaggttgtg cttgtctcag 20 1904 22 DNA Homo sapiens 1904 ccctagtgcc atatgatgaa gg 22 1905 23 DNA Homo sapiens 1905 aaccctagtg ccatatgatg aag 23 1906 29 DNA Homo sapiens 1906 cagtagtgtt aagtatattc acattgttg 29 1907 20 DNA Homo sapiens 1907 ctttccactg gctcaaatgc 20 1908 20 DNA Homo sapiens 1908 aagcacctcc tcctctttgg 20 1909 26 DNA Homo sapiens 1909 aggctttact cgtttgtata catcca 26 1910 23 DNA Homo sapiens 1910 tgtgtaatgc attttgctct gtc 23 1911 23 DNA Homo sapiens 1911 caaatgtgta atgcattttg ctc 23 1912 23 DNA Homo sapiens 1912 tgcaaatgta aaaatgcaaa gtg 23 1913 21 DNA Homo sapiens 1913 ccacacaact caagggagaa g 21 1914 19 DNA Homo sapiens 1914 ccagctgggt cagagaagc 19 1915 19 DNA Homo sapiens 1915 gtaagcctct gcccctgtg 19 1916 19 DNA Homo sapiens 1916 ctacggccag aagccctac 19 1917 20 DNA Homo sapiens 1917 tctacctcag ccaagcacag 20 1918 20 DNA Homo sapiens 1918 tgcaatttac atcccacagg 20 1919 21 DNA Homo sapiens 1919 gcaatttaca tcccacagga g 21 1920 21 DNA Homo sapiens 1920 tctccactgt ctctgggagt c 21 1921 18 DNA Homo sapiens 1921 ccttgtctgg ggcaggtg 18 1922 20 DNA Homo sapiens 1922 ccgttgtgcc aattagtgtg 20 1923 23 DNA Homo sapiens 1923 cactcatcct taccaacctt cac 23 1924 20 DNA Homo sapiens 1924 gcaaagccag gactcaaacc 20 1925 22 DNA Homo sapiens 1925 gggctcctga atcaatactt tg 22 1926 20 DNA Homo sapiens 1926 taggttttgt caccggcttc 20 1927 20 DNA Homo sapiens 1927 gcagggaaat gagtgagagc 20 1928 20 DNA Homo sapiens 1928 cgtccaaacc tatcccagtc 20 1929 29 DNA Homo sapiens 1929 agtaagagag agtgaaacaa ctaaaggta 29 1930 25 DNA Homo sapiens 1930 gaaaggactt ctgtttttgt ttttc 25 1931 26 DNA Homo sapiens 1931 tgtttcaata tttaagagaa gtgctg 26 1932 19 DNA Homo sapiens 1932 gtgatttggg gtggaggag 19 1933 27 DNA Homo sapiens 1933 tttcagtgac acaatttgat attaacc 27 1934 20 DNA Homo sapiens 1934 tcagctgtca ttcctcatgg 20 1935 18 DNA Homo sapiens 1935 ccctccccat cagcttcc 18 1936 20 DNA Homo sapiens 1936 gtgtgcatct ggcatgtagg 20 1937 18 DNA Homo sapiens 1937 ggaggccaca gctgacac 18 1938 20 DNA Homo sapiens 1938 atgggttttg ggaatcactg 20 1939 18 DNA Homo sapiens 1939 aaggggtggt tggctctc 18 1940 22 DNA Homo sapiens 1940 tttcacattt tgtgcgtgat ac 22 1941 24 DNA Homo sapiens 1941 tgctgtgatt accattttag ttgc 24 1942 27 DNA Homo sapiens 1942 tcttctctgg agaaaaaaag attaaac 27 1943 25 DNA Homo sapiens 1943 tctatgacaa agaatgatgt ttgag 25 1944 21 DNA Homo sapiens 1944 agccattgtt tcagaatcac c 21 1945 23 DNA Homo sapiens 1945 gcacttttcc tttgagaact gtg 23 1946 27 DNA Homo sapiens 1946 tgaacctaaa actaaaaagc tacattg 27 1947 24 DNA Homo sapiens 1947 aaaatgaagc tcataaaggg tttg 24 1948 21 DNA Homo sapiens 1948 tgtggtttac catttcattg c 21 1949 26 DNA Homo sapiens 1949 ccaaactaat ttttgagaca agataa 26 1950 24 DNA Homo sapiens 1950 gatttcaaat actgaagcca cttg 24 1951 23 DNA Homo sapiens 1951 ccaagaccta ctgatttcct ttc 23 1952 21 DNA Homo sapiens 1952 gcccagaccc cttgtaagta g 21 1953 20 DNA Homo sapiens 1953 aggccatcga tattctttgc 20 1954 20 DNA Homo sapiens 1954 cacctctctg ctgcttttgg 20 1955 20 DNA Homo sapiens 1955 gttcccccac cttagcagag 20 1956 20 DNA Homo sapiens 1956 aggtgaggtg gggagtgatg 20 1957 20 DNA Homo sapiens 1957 cggtagcctt acagggtgtc 20 1958 20 DNA Homo sapiens 1958 ggagagatcc agtggaccag 20 1959 18 DNA Homo sapiens 1959 cagctgggcc ttctaggg 18 1960 25 DNA Homo sapiens 1960 gaaaaatctt caccacacac taaag 25 1961 20 DNA Homo sapiens 1961 catgacaggg aacaggaagg 20 1962 21 DNA Homo sapiens 1962 ttcccattat gaggatgatg c 21 1963 21 DNA Homo sapiens 1963 cccattatga ggatgatgca g 21 1964 20 DNA Homo sapiens 1964 tgaggtgcct catgagattg 20 1965 20 DNA Homo sapiens 1965 tgcaatgtac tgggggtaag 20 1966 20 DNA Homo sapiens 1966 acgtgcacat tcacgcatac 20 1967 20 DNA Homo sapiens 1967 cttgctttgc catcttcctc 20 1968 19 DNA Homo sapiens 1968 caggggtgtg gcttctagg 19 1969 19 DNA Homo sapiens 1969 ccacatggga gtggatttc 19 1970 20 DNA Homo sapiens 1970 aacaccctga agggaaggac 20 1971 20 DNA Homo sapiens 1971 ggctgaggta gcaagtcagg 20 1972 20 DNA Homo sapiens 1972 cacctggtga gacccttgtc 20 1973 19 DNA Homo sapiens 1973 aggaacagcc cttccacac 19 1974 19 DNA Homo sapiens 1974 gaaggctctt gctccaagg 19 1975 20 DNA Homo sapiens 1975 ctgtcctttc cagcaacctc 20 1976 20 DNA Homo sapiens 1976 gggcctgtgt gagttgagtg 20 1977 20 DNA Homo sapiens 1977 cagggcctgt gtgagttgag 20 1978 20 DNA Homo sapiens 1978 atcctggtct tgtgggtcag 20 1979 21 DNA Homo sapiens 1979 tttgggggat tgaatacaga c 21 1980 20 DNA Homo sapiens 1980 tcagtgaggc aacactgtcc 20 1981 21 DNA Homo sapiens 1981 ttcagtgagg caacactgtc c 21 1982 23 DNA Homo sapiens 1982 ggacagtggg acatttttaa agc 23 1983 33 DNA Homo sapiens 1983 cctctataaa tatacttaca gactcaaaga tcc 33 1984 27 DNA Homo sapiens 1984 aatctgcata tacaagtcaa aataatg 27 1985 25 DNA Homo sapiens 1985 gccttagtag tctaagaggg catac 25 1986 28 DNA Homo sapiens 1986 tttgacacta ataaaaattt ctgggtaa 28 1987 20 DNA Homo sapiens 1987 aagacagtcc ccgctacaac 20 1988 19 DNA Homo sapiens 1988 ctgacatggc tggataccg 19 1989 20 DNA Homo sapiens 1989 ccagtctcct ctcccatcac 20 1990 20 DNA Homo sapiens 1990 taatgatggg gctggggtag 20 1991 21 DNA Homo sapiens 1991 gagtagtgtg agctgccttg g 21 1992 21 DNA Homo sapiens 1992 agcccttcag aagaggagaa g 21 1993 20 DNA Homo sapiens 1993 agggtcaggt ttggtgtctg 20 1994 20 DNA Homo sapiens 1994 accctgggga gtgaaagaag 20 1995 21 DNA Homo sapiens 1995 ggatgagaag attgggagag g 21 1996 21 DNA Homo sapiens 1996 ttggtgactc tggaggatga g 21 1997 18 DNA Homo sapiens 1997 gaacaccccc atcccttg 18 1998 19 DNA Homo sapiens 1998 ctcagtgcag gaggctgag 19 1999 20 DNA Homo sapiens 1999 caccaactga ccctcagtgc 20 2000 18 DNA Homo sapiens 2000 agggcctggg aggctggg 18 2001 20 DNA Homo sapiens 2001 gtatgctcct ggggtctctg 20 2002 20 DNA Homo sapiens 2002 acagatggga ggtgttcctg 20 2003 20 DNA Homo sapiens 2003 cctctggact ggaaaacagg 20 2004 18 DNA Homo sapiens 2004 gaccaaccgg gatgtgag 18 2005 20 DNA Homo sapiens 2005 cttcctcagc ctgcttcttc 20 2006 20 DNA Homo sapiens 2006 gaggctacag gtccagatcc 20 2007 20 DNA Homo sapiens 2007 agcaatcctc tcacctcagc 20 2008 20 DNA Homo sapiens 2008 ctcactgcag ccttgaactc 20 2009 20 DNA Homo sapiens 2009 atggtgctga agctcacttg 20 2010 20 DNA Homo sapiens 2010 ctggggttcc agagatgttc 20 2011 20 DNA Homo sapiens 2011 gcgagactcc gtctcaaaag 20 2012 20 DNA Homo sapiens 2012 gccttgtacc cctatgatgg 20 2013 20 DNA Homo sapiens 2013 cacctccctg gagtgtcaac 20 2014 20 DNA Homo sapiens 2014 ttggatgggt agggtttgag 20 2015 20 DNA Homo sapiens 2015 tacagaggtg ggcaggagtc 20 2016 19 DNA Homo sapiens 2016 agaggctgct gggtaggtg 19 2017 19 DNA Homo sapiens 2017 ggagttcgga ggtgagctg 19 2018 21 DNA Homo sapiens 2018 cttcctggct gaagcctcag t 21 2019 18 DNA Homo sapiens 2019 gtgcgctgag ctgtgtgg 18 2020 19 DNA Homo sapiens 2020 agtgctgctt gtcctgcac 19 2021 19 DNA Homo sapiens 2021 gtctgcaccc aggaaggtg 19 2022 21 DNA Homo sapiens 2022 tcctctgtaa agtgggtgga g 21 2023 20 DNA Homo sapiens 2023 cctctgtaaa gtgggtggag 20 2024 18 DNA Homo sapiens 2024 agggagatgg ggcagaac 18 2025 20 DNA Homo sapiens 2025 agatggggca gaactggatg 20 2026 20 DNA Homo sapiens 2026 tgtggtgggt catgtctgtg 20 2027 20 DNA Homo sapiens 2027 tcaaactccc caccaaactc 20 2028 20 DNA Homo sapiens 2028 ctcccagttg gaggagaaag 20 2029 20 DNA Homo sapiens 2029 gacatggcag cccaagtaag 20 2030 19 DNA Homo sapiens 2030 cagggagggt acgtgtgag 19 2031 20 DNA Homo sapiens 2031 ttttggattg gtgctcacac 20 2032 20 DNA Homo sapiens 2032 attccgaaca ttacccttgc 20 2033 18 DNA Homo sapiens 2033 ctgggtgagc ccaaggtg 18 2034 20 DNA Homo sapiens 2034 cccccttgct agtccacttc 20 2035 19 DNA Homo sapiens 2035 caggactgcc tgggaagag 19 2036 19 DNA Homo sapiens 2036 ggaatgaggt ggcttgagg 19 2037 20 DNA Homo sapiens 2037 tggcaagagt gtgagtgtcc 20 2038 20 DNA Homo sapiens 2038 cagatggtga gcagatccag 20 2039 20 DNA Homo sapiens 2039 cagatggtga gcagatccag 20 2040 24 DNA Homo sapiens 2040 aaagaggact tttgtgaaag atgg 24 2041 20 DNA Homo sapiens 2041 gcggagctcc tctttattcc 20 2042 21 DNA Homo sapiens 2042 ggcacatagc ctagtgagct g 21 2043 21 DNA Homo sapiens 2043 aagtttactg tcccccaaag c 21 2044 20 DNA Homo sapiens 2044 cattggccca ctgagacttc 20 2045 20 DNA Homo sapiens 2045 cctgactcta gggcacagac 20 2046 20 DNA Homo sapiens 2046 tggtgcacag aggctgtaac 20 2047 20 DNA Homo sapiens 2047 ggctgcagac ggtaagtagg 20 2048 20 DNA Homo sapiens 2048 gcagccctta cagttcttcc 20 2049 19 DNA Homo sapiens 2049 gtgccgaggg tcttgtctg 19 2050 20 DNA Homo sapiens 2050 ctggagggag aagaatggtg 20 2051 22 DNA Homo sapiens 2051 aatcaaagag cgttgtatga cc 22 2052 20 DNA Homo sapiens 2052 agcaagaagc ctgtcctcag 20

2053 19 DNA Homo sapiens 2053 gtggctccaa tgaggtgtg 19 2054 19 DNA Homo sapiens 2054 ctgtttcccc gtgtgtgtc 19 2055 20 DNA Homo sapiens 2055 agccctcctc tcagagttcc 20 2056 19 DNA Homo sapiens 2056 aggaaatgcc cagcaagag 19 2057 20 DNA Homo sapiens 2057 ataggccttg gtgtgcattc 20 2058 23 DNA Homo sapiens 2058 gagctttcaa ccctagtttg ttg 23 2059 19 DNA Homo sapiens 2059 ggtgggggaa ggggtatag 19 2060 20 DNA Homo sapiens 2060 ggcaaatcaa accatgatgc 20 2061 20 DNA Homo sapiens 2061 ttgctttttc agccactttg 20 2062 21 DNA Homo sapiens 2062 tcccattgga gaagaaatca c 21 2063 20 DNA Homo sapiens 2063 gtgggggtgg gaattaaaac 20 2064 19 DNA Homo sapiens 2064 tgggggtggg aattaaaac 19 2065 24 DNA Homo sapiens 2065 ttgctgagaa ttctactcaa aagg 24 2066 20 DNA Homo sapiens 2066 ctgagactct gggtggcttc 20 2067 20 DNA Homo sapiens 2067 tgacccatag ccttcctgac 20 2068 27 DNA Homo sapiens 2068 cattttaaaa gttgctagct ttaggac 27 2069 20 DNA Homo sapiens 2069 ggaagaatgt gcatgccaag 20 2070 21 DNA Homo sapiens 2070 cagggaggct ccatataaag g 21 2071 20 DNA Homo sapiens 2071 ccatgaagtc agctgtcagg 20 2072 18 DNA Homo sapiens 2072 gggtgagccc ctatctgg 18 2073 20 DNA Homo sapiens 2073 caggaatgcc cttagtgctg 20 2074 21 DNA Homo sapiens 2074 ggcaccattg ttctccatta g 21 2075 20 DNA Homo sapiens 2075 cagaagctga caagcagcag 20 2076 20 DNA Homo sapiens 2076 taaggctcag aggggctacc 20 2077 20 DNA Homo sapiens 2077 ggtggagtca gtgtgaaagg 20 2078 19 DNA Homo sapiens 2078 gcccacagca actacaagg 19 2079 20 DNA Homo sapiens 2079 agatgccacc ggttctacag 20 2080 20 DNA Homo sapiens 2080 cccctctctc tggttgtctg 20 2081 16 DNA Homo sapiens 2081 ggagaaggcc cggcgt 16 2082 20 DNA Homo sapiens 2082 tgcacacctt cgagaaacag 20 2083 23 DNA Homo sapiens 2083 ggctatttct ggtgtaggaa atc 23 2084 20 DNA Homo sapiens 2084 aaggtcgagg atgcagtgag 20 2085 20 DNA Homo sapiens 2085 agaaggtcga ggatgcagtg 20 2086 22 DNA Homo sapiens 2086 aagatggagt ctcactctga cg 22 2087 21 DNA Homo sapiens 2087 gagctgctga gaagaatttg c 21 2088 20 DNA Homo sapiens 2088 cgggagtgtt gcttttattg 20 2089 21 DNA Homo sapiens 2089 acgggagtgt tgcttttatt g 21 2090 20 DNA Homo sapiens 2090 ttccagctct tcctgcattc 20 2091 21 DNA Homo sapiens 2091 aatgaccatt ggctattttg g 21 2092 20 DNA Homo sapiens 2092 gcactgcagt aaagcaaagg 20 2093 20 DNA Homo sapiens 2093 ccggtgaagt ctcaggaatg 20 2094 21 DNA Homo sapiens 2094 ttctagaggc aggttggttt g 21 2095 20 DNA Homo sapiens 2095 gcaagaaagt ggagctggag 20 2096 25 DNA Homo sapiens 2096 ccttgtgaga ggttataaga caaag 25 2097 22 DNA Homo sapiens 2097 gctttatagt cccctggtat cc 22 2098 21 DNA Homo sapiens 2098 ttaggcactt ccaactgaag g 21 2099 30 DNA Homo sapiens 2099 aagactcaca tttaggaaat acatatagaa 30 2100 20 DNA Homo sapiens 2100 ttggtgtttg gattgacctg 20 2101 23 DNA Homo sapiens 2101 caacattttt caaacttttg ctc 23 2102 24 DNA Homo sapiens 2102 tgaatttttc aaccatttgt tatg 24 2103 20 DNA Homo sapiens 2103 tacgacccat gtggcttttc 20 2104 19 DNA Homo sapiens 2104 gcctctcgtg tttgtccac 19 2105 19 DNA Homo sapiens 2105 tggcttgcgg actctgtag 19 2106 21 DNA Homo sapiens 2106 tcctgttcct cccagtttaa g 21 2107 20 DNA Homo sapiens 2107 agccagcatt tcagatttcc 20 2108 20 DNA Homo sapiens 2108 aatcctagtg atggccgttg 20 2109 21 DNA Homo sapiens 2109 ttgccacttt ctcaactttc c 21 2110 20 DNA Homo sapiens 2110 tctgtgtgcc tgtgtgtgtg 20 2111 19 DNA Homo sapiens 2111 catcttcccc gccaactac 19 2112 19 DNA Homo sapiens 2112 cctggtgctg gagttcgcc 19 2113 20 DNA Homo sapiens 2113 catgccacag aaaaattgtg 20 2114 23 DNA Homo sapiens 2114 ggaatggatg aaggtactga agg 23 2115 25 DNA Homo sapiens 2115 ttaggaatgg atgaaggtac tgaag 25 2116 24 DNA Homo sapiens 2116 tttggaatga caaatgttaa gttg 24 2117 18 DNA Homo sapiens 2117 ggggtcgcca gtgtagtg 18 2118 20 DNA Homo sapiens 2118 ttgtcctgta gctggctgtg 20 2119 20 DNA Homo sapiens 2119 cccaccttta gacaggcaac 20 2120 21 DNA Homo sapiens 2120 tcattcctgt gacctgagtc c 21 2121 27 DNA Homo sapiens 2121 tgttttatgt tatattgtgc cagaaag 27 2122 19 DNA Homo sapiens 2122 ggggttctct gcgagtcac 19 2123 20 DNA Homo sapiens 2123 tggagagaca ctgtggttgc 20 2124 22 DNA Homo sapiens 2124 gagtttcctg tagcatgtga cc 22 2125 20 DNA Homo sapiens 2125 aggttctttt tccccctctc 20 2126 20 DNA Homo sapiens 2126 tttttccccc tctctgattc 20 2127 23 DNA Homo sapiens 2127 catctttctg gctcatcttt ttg 23 2128 25 DNA Homo sapiens 2128 tctgcaaatg ttgactaggt tacac 25 2129 22 DNA Homo sapiens 2129 aactgtgttt ttgattgcaa gg 22 2130 21 DNA Homo sapiens 2130 gatccatgtt tcctcatgtc c 21 2131 20 DNA Homo sapiens 2131 ggagttggag cagtgagagg 20 2132 21 DNA Homo sapiens 2132 aggagttgga gcagtgagag g 21 2133 20 DNA Homo sapiens 2133 gttggcaaga gtggaagacc 20 2134 20 DNA Homo sapiens 2134 ccactgtggg agaggctagg 20 2135 20 DNA Homo sapiens 2135 gagcacctgc ttggtctgag 20 2136 20 DNA Homo sapiens 2136 aaacgctacc aagggttgtg 20 2137 20 DNA Homo sapiens 2137 cctacgcagc acaccaatag 20 2138 20 DNA Homo sapiens 2138 cctacgcagc acaccaatag 20 2139 20 DNA Homo sapiens 2139 gttccagatg gggagatgag 20 2140 20 DNA Homo sapiens 2140 gcaaggtcca caaagtgttg 20 2141 19 DNA Homo sapiens 2141 tggacaacac agcaagacc 19 2142 25 DNA Homo sapiens 2142 tttcataatc ccatattgaa gacag 25 2143 26 DNA Homo sapiens 2143 tcccatattg aagacagaaa tagaag 26 2144 23 DNA Homo sapiens 2144 tgatggagta ttgaaggtag gac 23 2145 20 DNA Homo sapiens 2145 ccttcagata cggtgtttgc 20 2146 20 DNA Homo sapiens 2146 ttttgtgatg gtgggttgag 20 2147 20 DNA Homo sapiens 2147 ggaaaaggga gaagcagacc 20 2148 20 DNA Homo sapiens 2148 tctttgagac cgcctacagc 20 2149 20 DNA Homo sapiens 2149 tctaggacgc ttgcctcttc 20 2150 19 DNA Homo sapiens 2150 ggagcagagg gagttcctg 19 2151 20 DNA Homo sapiens 2151 gttctctggg ctgtctacgg 20 2152 18 DNA Homo sapiens 2152 ctggtcccct gccttttg 18 2153 18 DNA Homo sapiens 2153 cacctgccct caaaccac 18 2154 18 DNA Homo sapiens 2154 ctgccctcaa accacctg 18 2155 20 DNA Homo sapiens 2155 gaagccatct gcacatctcc 20 2156 20 DNA Homo sapiens 2156 gagccactca caccagagag 20 2157 19 DNA Homo sapiens 2157 acagctcctt ccccagcag 19 2158 20 DNA Homo sapiens 2158 gcttgatgga aggacagcag 20 2159 18 DNA Homo sapiens 2159 gggcactgct gtcccttg 18 2160 21 DNA Homo sapiens 2160 ttaccccgat tttggttaag g 21 2161 19 DNA Homo sapiens 2161 ttcctggcag caaaatctg 19 2162 20 DNA Homo sapiens 2162 cccagctaga agagcaaagg 20 2163 21 DNA Homo sapiens 2163 tcccagctag aagagcaaag g 21 2164 18 DNA Homo sapiens 2164 gggaagggtc aggggttg 18 2165 20 DNA Homo sapiens 2165 tccctggctt agattcttgg 20 2166 20 DNA Homo sapiens 2166 cccaggctaa gggtcttcag 20 2167 20 DNA Homo sapiens 2167 actgagtgct aatggcgatg 20 2168 20 DNA Homo sapiens 2168 ggcctccacg aagtacaaag 20 2169 20 DNA Homo sapiens 2169 atgttcccct tggtgagttg 20 2170 27 DNA Homo sapiens 2170 cctctctgtc aaataataga tacttcc 27 2171 27 DNA Homo sapiens 2171 ttgataatga gagtgataaa tagatgg 27 2172 20 DNA Homo sapiens 2172 agtgtggggt ccaaataacc 20 2173 27 DNA Homo sapiens 2173 caacttagag ttaactaaag ggatttg 27 2174 21 DNA Homo sapiens 2174 cctggagcac aaaaataatg c 21 2175 20 DNA Homo sapiens 2175 gcttagcgtt ccaaaaatgg 20 2176 22 DNA Homo sapiens 2176 ccttatcaag gtgtgtgtct gg 22 2177 18 DNA Homo sapiens 2177 agggttggtg gtgtctgg 18 2178 20 DNA Homo sapiens 2178 cctcccacat cttggtcttc 20 2179 20 DNA Homo sapiens 2179 agtgaacagc cccatgagag 20 2180 20 DNA Homo sapiens 2180 ccaaaactca gcctgacctc 20 2181 20 DNA Homo sapiens 2181 gtgagccaat ggaaatgagg 20 2182 22 DNA Homo sapiens 2182 aaatctcatc ttctgggtct gg 22 2183 19 DNA Homo sapiens 2183 gggctctctt caggacctc 19 2184 20 DNA Homo sapiens 2184 gggaacaagt gagggtcctg 20 2185 20 DNA Homo sapiens 2185 ggtccctgaa gctagtgagc 20 2186 21 DNA Homo sapiens 2186 cacatcagta ggaccctgca c 21 2187 20 DNA Homo sapiens 2187 atgcccctaa gcacctattg 20 2188 20 DNA Homo sapiens 2188 atgcatccag atcagtttcg 20 2189 20 DNA Homo sapiens 2189 atgccttggt cttggacttc 20 2190 20 DNA Homo sapiens 2190 ccatctctga gtgcatggtg 20 2191 20 DNA Homo sapiens 2191 accagagcac aagcaatcag 20

Claims

1. A method for detecting mutations involved in cancer, comprising: identifying members of a family of genes in a database of human nucleotide sequences based on homology to a known member of the family; determining nucleotide sequence differences in a selected region of each of the members of the family of genes in matched pairs of an individual's cancer cells and normal cells, said differences identifying members of heightened interest; determining additional nucleotide sequence differences in the members of heightened interest, either in one or more additional regions outside of the selected region, or in matched pairs of cancer cells and normal cells of additional individuals, or in both.

2. The method of claim 1 wherein the selected region encodes a catalytic domain.

3. The method of claim 1 wherein the selected region encodes a regulatory domain.

4. The method of claim 1 further comprising determining whether a nucleotide sequence difference is synonymous or non-synonymous, wherein a non-synonymous mutation is more likely to be functionally relevant to cancer.

5. The method of claim 4 further comprising determining whether a nucleotide difference affects an evolutionarily conserved amino acid residue, wherein such a difference is more likely to be functionally relevant to cancer.

6. The method of claim 4 further comprising determining whether a nucleotide difference affects a residue within a catalytic domain, wherein such a difference is more likely to be functionally relevant to cancer.

7. The method of claim 4 further comprising determining whether a nucleotide difference affects a first amino acid residue which is a positional equivalent of a second amino acid residue in a protein encoded by another member of the family of genes, wherein mutation of said second residue in the protein encoded by another member of the family causes disease, wherein such a difference affecting the first amino acid is more likely to be functionally relevant to cancer.

8. The method of claim 4 further comprising determining whether a nucleotide difference affects a first amino acid residue which is within 5 amino acid residues of an equivalent of a second amino acid residue in a protein encoded by another member of the family of genes, wherein mutation of said second residue in the protein encoded by another member of the family causes disease, wherein such a difference affecting the first amino acid is more likely to be functionally relevant to cancer.

9. The method of claim 8 wherein the first amino acid residue is within 3 amino acid residues of the equivalent of the second amino acid residue.

10. The method of claim 8 wherein the first amino acid residue is within 1 amino acid residues of the equivalent of the second amino acid residue.

11. A method of screening test substances for use as anti-cancer agents, comprising: contacting a test substance with an activated protein kinase selected from the group consisting of: NTRK3, FES, MCCK, EPHA3, NTRK2, INSRR, JAK1, PDGFRA, EPHA7, EPHA8, KDR, FGFR1, and ERBB4; testing activity of the activated protein kinase, wherein a test substance which inhibits the activity of the activated protein kinase is a potential anti-cancer agent.

12. The method of claim 11 wherein the activated protein kinase is in a cell.

13. The method of claim 11 wherein the activated protein kinase is isolated from a cell.

14. The method of claim 11 wherein the activated protein kinase is in a cell of a cancer cell line.

15. The method of claim 11 wherein the activated protein kinase is in a cell which has been modified to express the activated protein kinase.

16. The method of claim 11 wherein the activated protein kinase is NTRK3.

17. The method of claim 11 wherein the activated protein kinase is FES.

18. The method of claim 11 wherein the activated protein kinase is MCCK.

19. The method of claim 11 wherein the activated protein kinase is EPHA3.

20. The method of claim 11 wherein the activated protein kinase is NTRK2.

21. The method of claim 11 wherein the activated protein kinase is INSRR.

22. The method of claim 11 wherein the activated protein kinase is JAK1.

23. The method of claim 11 wherein the activated protein kinase is PDGFRA.

24. The method of claim 11 wherein the activated protein kinase is EPHA7.

25. The method of claim 11 wherein the activated protein kinase is EPHA8.

26. The method of claim 11 wherein the activated protein kinase is ERBB4.

27. The method of claim 11 wherein the activated protein kinase is FGFR1.

28. The method of claim 11 wherein the activated protein kinase is KDR.

29. The method of claim 16 wherein the activated NTRK3 protein kinase has a mutation from the group consisting of I695V, G608S, L760I, K732T, and R731Q.

30. The method of claim 17 wherein the activated FES protein kinase has a mutation from the group consisting of M704V, R706Q, V743M, and S759F.

31. The method of claim 18 wherein the activated MCCK protein kinase has a mutation from the group consisting of H261Y, H261Q, G291E, A293E, W296STP, R470C, R553Stp, N596I, and K629E.

32. The method of claim 19 wherein the activated EPHA3 protein kinase has a mutation from the group consisting of S792P and D806N.

33. The method of claim 20 wherein the activated NTRK2 protein kinase has a mutation from the group consisting of T695I and D751N.

34. The method of claim 21 wherein the activated INSRR protein kinase has a mutation T985M.

35. The method of claim 22 wherein the activated JAK1 protein kinase has a mutation E886K.

36. The method of claim 23 wherein the activated PGDFRA protein kinase is the result of a G.fwdarw.A splice site mutation at position 1 of the donor site of exon 15.

37. The method of claim 24 wherein the activated EPHA7 protein kinase has a mutation S768I.

38. The method of claim 25 wherein the activated EPHA8 protein kinase has a mutation D873N.

39. The method of claim 26 wherein the activated ERBB4 protein kinase is I1030M.

40. The method of claim 27 wherein the activated FGFR1 protein kinase has a mutation A429S.

41. The method of claim 28 wherein the activated KDR protein kinase has a mutation selected from the group consisting of G800D, R819Stop, and A1073T.

42. A method of screening test substances for use as anti-cancer agents, comprising: contacting a test substance with a mutated GUCY2F guanylate cyclase; testing activity of the mutated GUCY2F guanylate cyclase, wherein a test substance which increases the activity of the mutated GUCY2F guanylate cyclase is a potential anti-cancer agent.

43. The method of claim 42 wherein the mutated GUCY2F guanylate cyclase is in a cell.

44. The method of claim 42 wherein the mutated GUCY2F guanylate cyclase is isolated from a cell.

45. The method of claim 42 wherein the mutated GUCY2F guanylate cyclase is in a cell of a cancer cell line.

46. The method of claim 42 wherein the mutated GUCY2F guanylate cyclase is in a cell which has been modified to express the activated protein kinase.

47. The method of claim 42 wherein the mutated GUCY2F guanylate cyclase has a mutation selected from the group consisting of D225Y, A360T, Q361H, F390L, R492H, R545S, E624D, E778G, the result of a T.fwdarw.C splice site mutation at position 2 of the donor splice site of exon 17, and V1026M.

48. An isolated, activated protein kinase selected from the group consisting of: NTRK3, FES, MCCK, GUCY2F, EPHA3, NTRK2, INSRR, JAK1, PDGFRA, EPHA7, EPHA8, KDR, FGFR1, and ERBB4.

49. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is NTRK3.

50. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is FES.

51. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is MCCK.

52. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is EPHA3.

53. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is NTRK2.

54. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is INSRR.

55. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is JAK1.

56. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is PDGFRA.

57. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is EPHA7.

58. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is EPHA8.

59. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is ERBB4.

60. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is KDR.

61. The isolated, activated tyrosine of claim 48 wherein the activated protein kinase is FGFR1.

62. The isolated, activated tyrosine of claim 49 wherein the activated NTRK3 protein kinase has a mutation from the group consisting of I695V, G608S, L760I, K732T, and R731Q.

63. The isolated, activated tyrosine of claim 50 wherein the activated FES protein kinase has a mutation from the group consisting of M704V, R706Q, V743M, and S759F.

64. The isolated, activated tyrosine of claim 51 wherein the activated MCCK protein kinase has a mutation from the group consisting of H261Y, H261Q, G291E, A293E, W296STP, R470C, R470C, R553Stp, N596I, and K629E.

65. The isolated, activated tyrosine of claim 52 wherein the activated EPHA3 protein kinase has a mutation from the group consisting of S792P and D806N.

66. The isolated, activated tyrosine of claim 53 wherein the activated NTRK2 protein kinase has a mutation from the group consisting of T695I and D751N.

67. The isolated, activated tyrosine of claim 54 wherein the activated INSRR protein kinase has a mutation T985M.

68. The isolated, activated tyrosine of claim 55 wherein the activated JAK1 protein kinase has a mutation E886K.

69. The isolated, activated tyrosine of claim 56 wherein the activated PGDFRA protein kinase is the result of a G.fwdarw.A splice site mutation at position 1 of the donor site of exon 15.

70. The isolated, activated tyrosine of claim 57 wherein the activated EPHA7 protein kinase has a mutation S768I.

71. The isolated, activated tyrosine of claim 58 wherein the activated EPHA8 protein kinase has a mutation D873N.

72. The isolated, activated tyrosine of claim 59 wherein the activated ERBB4 protein kinase has a mutation I1030M.

73. The isolated, activated tyrosine of claim 60 wherein the activated KDR protein kinase has a mutation selected from the group consisting of G800D, R819Stop, and A1073T.

74. The isolated, activated tyrosine of claim 61 wherein the activated FGFR1 protein kinase has a mutation A429S.

75. An isolated, mutated GUCY2F protein.

76. The isolated, mutated GUCY2F protein of claim 75 which has a mutation from the group consisting of D225Y, A360T, Q361H, F390L, R492H, R545S, E624D, E778G, the result of a T.fwdarw.C splice site mutation at position 2 of the donor splice site of exon 17, and V1026M.

77. A method of categorizing cancers, comprising: determining the sequence of one or more protein kinase family members selected from the group consisting of NTRK3, FES, MCCK, EPHA3, NTRK2, INSRR, JAK1, PDGFRA, EPHA7, EPHA8, GUCY2F, KDR, FGFR1, and ERBB4 in a sample of a cancer tissue; identifying a somatic mutation of said one or more protein kinase family members in the cancer tissue; assigning the cancer tissue to a set based on the presence of the somatic mutation.

78. The method of claim 77 wherein the mutation is one which activates protein kinase activity.

79. The method of claim 78 wherein the protein kinase family member is NTRK3.

80. The method of claim 78 wherein the protein kinase family member is FES.

81. The method of claim 78 wherein the protein kinase family member is MCCK.

82. The method of claim 78 wherein the protein kinase family member is EPHA3.

83. The method of claim 78 wherein the protein kinase family member is NTRK2.

84. The method of claim 78 wherein the protein kinase family member is INSSR.

85. The method of claim 78 wherein the protein kinase family member is JAK1.

86. The method of claim 78 wherein the protein kinase family member is PDGFRA.

87. The method of claim 78 wherein the protein kinase family member is EPHA7.

88. The method of claim 77 wherein the protein kinase family member is GUCY2F.

89. The method of claim 78 wherein the protein kinase family member is ERBB4.

90. The method of claim 78 wherein the protein kinase family member is EPHA8.

91. The method of claim 78 wherein the protein kinase family member is KDR.

92. The method of claim 78 wherein the protein kinase family member is FGFR1.

93. The method of claim 77 wherein the set is used to analyze or design clinical trials.

94. The method of claim 77 wherein the set is used to correlate with prognostic data.

95. The method of claim 77 wherein the set is used to correlate with recurrence data.

96. The method of claim 77 wherein the set is used to select an appropriate therapeutic agent.